Miracle-dz/UniFAR-FTUs huggingface dataset:
Solar Power Generation System with Seven Level Inverter: A Critical Review

This paper presents a single-stage circuit topology consisting of the association of a full-bridge isolated dc–dc converter and two input inductors and two input diodes connected to the mains network, in order to obtain an isolated ac/dc switch mode power supply, with sinusoidal input current. The proposed topology does not use an input bridge rectifier, common in similar applications. The current in the two input inductors can therefore, flow in both directions. Consequently, the proposed topology equally distributes the current by the four-bridge transistors that provide four input parallel boost power factor correctors (PFCs). The use of the four bridges permitting the accurate simultaneous regulation of output voltage and input current is hereby described. Keywords— Full-bridge converters, Input current shaping, low-distortion input current, single-stage power factor correctors (PFCs)
Statistical Analysis of HRV Parameters for the Detection of Arrhythmia

The repolarization and depolarization in heart generate electrical signals in the form of an ECG wave. The condition of the heart can be indicated by using Heart Rate Variability (HRV) features. In this work, FIR filter is used at the pre-processing phase for denoising, and then statistical analysis is applied for time-domain HRV feature extraction and selection. This algorithm is evaluated on different records of MIT/BIH Normal Sinus Rhythm and Arrhythmia database. The [Formula: see text]-test implementation in both databases shows that there are significant variations in HRV features, where meanRR and HR have suggestive significant ([Formula: see text]) changes, while maxRR, minRR, maxminRR, and SDNN have strongly significant ([Formula: see text]) changes. To validate the statistical analysis of HRV, feature classification has been done using SVM and kNN classifiers. A significant improvement of 2% and 14.02% has been observed in the overall accuracy of SVM and kNN classifiers after feature selection, respectively. These HRV features can be used for the early prediction of various Cardio-Vascular Diseases (CVD).
Insights Into Hiv-1 Coreceptor Engagement And Its Contribution To Membrane Fusion

During HIV-1 entry, CD4 and a coreceptor (either CCR5 or CXCR4) must interact with the envelope glycoprotein (Env). The coreceptor N-terminus and extracellular loops are critical domains that interact cooperatively with Env to drive the release of gp41 for fusion with the host membrane. Conformational changes in Env that follow coreceptor engagement to trigger fusion are poorly understood. We explored the individual contribution of interactions between an HIV-1 Env and the coreceptor N-terminus with a variant, termed CEMAX, that mediated fusion and infection using a coreceptor construct that expressed only the first 27 residues of the CXCR4 N-terminus, fused to a CD4 anchoring molecule (X4-NT/CD4). CEMAX acquired mutations in gp41, but also contained a severely truncated V3 loop in gp120. Here we describe the derivation and characterization of HIV-1s with full V3 loops and combinations of these gp41 changes that enabled efficient utilization of an R5-NT/CD4 construct containing the first 19 residues of CCR5 fused to a CD4 anchoring molecule. The determinants for this gain of function were mapped to gp41 mutations in: the fusion peptide, an N-terminal helical domain, and heptad repeat-2. We demonstrated that these changes in heterologous HIV-1s conferred the same phenotype. We also evaluated the mechanism of this novel “Nterminus only” usage of CCR5. Although global changes in trimer architecture were not detected by several antibodies, the acquisition of N-terminus only usage was associated with reduced sensitivity to a gp41 fusion inhibitor, consistent with more rapid fusion kinetics. Our findings also indicated that infection of cells expressing CD4 and R5-NT/CD4 was markedly enhanced in the absence of Vpu and in the presence of tetherin, likely as a result of tetherin-mediated formation of cell-associated viral aggregates and facilitation of cell-to-cell spread. Based on new structural insights of the CD4-activated trimer in its final conformational state before coreceptor engagement, this novel phenotype is consistent with a model in which gp41 mutations destabilize interactions between the gp41 N-terminus and a CD4-induced pocket formed near the trimer core, lowering the threshold for triggering and enabling the coreceptor N-terminus to become sufficient for gp41 release and cell fusion. Degree Type Dissertation Degree Name Doctor of Philosophy (PhD) Graduate Group Cell & Molecular Biology First Advisor James A. Hoxie
The Role of Akt2 and CA-125 Serum Levels as Predictors for Successful Cytoreduction in Epithelial Ovarian Cancer Surgery

Ovarian cancer is one of the common causes of cancer deaths in gynecological malignancies in Indonesia, and indeed the world. Of all classifications of ovarian cancer, the epithelial subtype shows the highest incidence. Cytoreductive surgery is a determinant of prognosis for patients with advanced epithelial ovarian cancer. One possible way to predict the results of cytoreductive surgery is to measure preoperative tumor marker levels. This study aimed to assess the validity of serum levels of Protein kinase Bβ (Akt2) and cancer antigen-125 (CA-125) as outcome predictors for cytoreduction in epithelial ovarian cancer surgery. This was an observational, analytical, cross-sectional study. Akt2 and CA-125 serum levels were examined by enzyme-linked immunosorbent assay (ELISA) and immunoassay technique, respectively. Mean levels of Akt2 and CA-125 were significantly different between optimal and suboptimal cytoreduction groups (p < 0.05). The cut-off point (COP) value obtained for Akt2 was 1.20 U/mL with area under curve (AUC) value of 68.9%, while the COP for CA-125 was 222.50 U/mL with AUC value of 75.3 % (p < 0.05). If the preoperative Akt2 serum level was greater than 1.20 U/mL, and preoperative CA-125 level was greater than 222.5 U/mL, the probability of suboptimal cytoreduction was increased. Thus, our study highlights the possibility for Akt2 and CA-125 levels to be used as serum biomarkers in predicting the success of cytoreductive surgery.
Language assessment tools for Arabic-speaking heritage and refugee children in Germany

Abstract Though Germany has long provided education for children speaking a heritage language and received two recent waves of refugees, reliable assessment tools for diagnosis of language impairment or the progress in the acquisition of German as a second language (L2) by refugee children are still lacking. The few tools expressly targeting bilingual populations are normed for younger, early successive bilingual children. This study investigates 27 typically developing children with Arabic as first language (L1), comparing 15 school-age Syrian refugees (6;6–12;8), with 12 heritage speakers (6;0–12;9). We assess the L1 and L2 skills of these two groups with standardized tests, but crucially with an Arabic and a German sentence repetition (SRT) as well as a nonword (NWRT) repetition task (Grimm & Hübner, in press; Marinis & Armon-Lotem, 2015). Comparable scores emerged only for German LITMUS-NWRT and Arabic LITMUS-SRT. Refugee children had an advantage in L1 measures, for example, vocabulary and morphosyntactic production, whereas they performed poorly in the German LITMUS-SRT and other L2 tests involving morphosyntax and vocabulary even with 24 months of systematic exposure. This indicates that the acquisition of adequate vocabulary and complex syntax takes time. The paper explores factors influencing performance on the repetition tasks and relates the results to established diagnostic procedures and educational policies.
Mitochondrial DNA and morphometrical identification of a new species of Hylomyscus (Rodentia: Muridae) from West Africa

In this paper we describe a new species of Hylomyscus based on molecular (Cyt b and 16S rDNA gene sequencing) and morphometrical analyses. This new species occurs in Benin and Nigeria, and probably also in Togo. It differs by 8.29 to 10.40 % of sequence divergence (K2P distance for the Cyt b gene) from all other species of the H. alleni species complex, and can be distinguished from these species through morphometrical multivariate analyses. It differs significantly from its closest relative, H. simus, by four external and nine cranio-dental measurements. The role of rivers and Pleistocene forest refugia in the diversification of the H. alleni species complex is discussed.
Intervención nutricional durante la lesión muscular considerando su fisiopatología: artículo de revisión

La lesion genera costos fisicos, emocionales y economicos, por lo que se han buscado estrategias para acortar al maximo el periodo de recuperacion. Una herramienta infrautilizada es la nutricional. Se presenta una revision de la literatura cientifica mediante una busqueda en 4 bases de datos (Pubmed/MEDLINE, Epistemonikos, Embase y Sportdiscus) sobre la fisiopatologia de la lesion muscular y su modulacion nutricional. Se describen cambios locales mediados por celulas y mediadores inflamatorios, y cambios secundarios en la composicion corporal. Las intervenciones nutricionales publicadas comprenden el aumento de las proteinas de la dieta y ajuste de carbohidratos acorde a su menor gasto energetico. No existen estudios que hayan evaluado directamente el uso de suplementos durante la lesion, pero si evidencia indirecta, la mayoria favorable, en sarcopenia y recuperacion muscular. La intervencion nutricional durante la lesion es fundamental para disminuir las consecuencias negativas de la inactividad, la cual debe ser indicada de manera individualizada.
The effects of thermal and ethanolic stress in industrial strains of Saccharomyces cerevisiae

Saccharomyces cerevisiae is exceptional microorganisms used in biotechnological processes, mainly in the ethanol production chain. Studies of the cellular responses of industrial yeasts under ethanolic and thermal stress in an association are still incipient. This study aimed to evaluate the action of thermal and ethanolic stress in industrial strains of Saccharomyces cerevisiae under different temperatures and concentrations of ethanol, to understand whether these factors influence ethanol production. For cytotoxicity and genotoxicity tests, yeasts were grown in 2% YPD medium incubated for 10 hours at 250 rpm. After growth, the samples were grown in sugarcane juice in concentrations of 5, 10 and 15% ethanol and incubated at 30 and 40 oC. In Petri dishes containing the solid medium YPD 2% the yeasts were dripped and incubated for 72 hours the cytotoxic action was analyzed by cell growth and genotoxicity through the comet assay and ethanol production by gas chromatography. Cell growth occurred in all conditions, however, at 30 oC there was inhibition in 10% (v v-1) of ethanol being potentiated in 15% (v v-1), at 40 oC. The genotoxicity analysis showed an induction of DNA damage in yeasts, however, the FLE yeast was the one with the highest DNA damage index. The yeast Pedra-2 was more tolerant and produced more ethanol, showing to be a tolerant strain concerning the analyzed fermentative interferents.
Reversible Photocontrol of Lipase Activity by Incorporating a Photoswitch into the Lid Domain

Photocontrol of enzymatic activity has become a helpful strategy to control biological processes. Herein, a method for the reversible photocontrol of lipase activity was developed by utilizing the conformational change of the lid structure. A bifunctional azobenzene derivative, whose trans/cis-form photoisomerization processes could be used to control the folded and unfolded conformations of the α-helix structure, was cross-linked with two cysteine residues on the lid domain to achieve photocontrol of lipase activity. To screen for the optimum sites of cross-linking, several cysteine-replaced lipase variants were constructed. The variant C127C138 attached with a cross-linker showed a threefold fully reversible activity change after illumination with UV and blue light. Furthermore, the structural change in the α-helix of the lipase was confirmed by circular dichroism. This strategy could be applied for photocontrolling activity of other enzymes where an α-helix is an important structural component.
The Role of Stat3 in Mouse Models of Inherited Photoreceptor Degeneration

Inherited photoreceptor degeneration (IPD), one of the main causes of inherited blindness, is characterized by progressive death of mutant photoreceptors (PRs). To date, mutations in over 186 genes have been associated with IPD. Unfortunately, little progress has been made towards treatment to prevent PR death. Here I show that expression of the signal transducer and activator of transcription 3 (STAT3), a transcription factor responsive to IL-6 family cytokines, is increased and activated by tyrosine phosphorylation in both PRs and Müller glia of three mouse models of IPD (Tg(RHO P347S), Prph2 rds+/and Pde6b rd1/rd1 ). To determine whether this endogenous activation of Stat3 expression influence PR degeneration, I genetically manipulated Stat3 expression in these two cell types in three models of IPD. PR-specific deletion of Stat3 significantly accelerated PR death in Tg(RHO P347S) and Prph2 rds+/retinas. In Tg(RHO P347S) mice following PR-Stat3 deletion, PR survival decreased by an average of 40% at PN20 (n=6, p<0.01), and an average of 67% (n=5, p<0.001) at PN30. Similarly, in Prph2 rds+/mice at 6 months, PR-Stat3 deletion decreased PR survival by an average of 50% decrease (n=9; p<0.001). These data revealed, for the first time, that the increased expression of endogenously activated PR-STAT3 is a survival
The Price for Market Embeddedness is Declining Adaptive Capabilities: Model, Measurement and Illustration

This paper deals with a central challenge in organization and management research: to predict the evolution of an organization’s adaptive capability. We address both theoretical and methodological gaps in existing research. First, focusing on the largely overlooked external constraints on adaptive capability, we model how ties between an organization and its market audiences curtail adaptive capability as market tenure increases. Second, we address the methodological weakness of conceptualizing the content of organizational change in prior research with a novel approach. Our distance-based approach sees adap- tation as change in an organization’s position in a cognitive market space. With position defined, one can measure the speed of movement in that space. An analysis of the UK motorcycle market serves as an empirical illustration for our theoretical prediction and proposed measure.
Noise affects porpoise click detections – the magnitude of the effect depends on logger type and detection filter settings

Abstract Automatic click detectors and full-bandwidth sound recorders are widely used in passive acoustic monitoring of small cetaceans. Detection of these signals depends on a variety of factors, including signal to noise ratio. Passive acoustic monitoring is often used to study impact of underwater noise on small cetaceans, but as detection probability is affected by changes in signal to noise ratio, variable noise levels may affect conclusions drawn from these experiments. Therefore, we examine how different detectors and filters perform in varying ocean noise conditions. C-PODs and full-bandwidth recorders (Wildlife Acoustics, SM2M+) were deployed at two stations in an environment with fluctuating ambient noise for 42 days. Noise level and harbour porpoise (Phocoena phocoena) click trains simultaneously recorded on both loggers were compared. Overall, we found that porpoise click detections by the algorithm used to analyse full-band recorder data (Pamguard) paralleled detections by the C-POD. However, Pamguard detected significantly more clicks than the C-POD. A decrease in detections was seen for both loggers with increasing noise in the band 20 –160 kHz, in particular for levels above 100 dB re 1μPa rms. We also found that the Pamguard detection function changed the least over varying noise conditions when compared to the C-POD detectors. This study sheds light on the fact that inference of animal presence/absence or density that are based on echolocation cues (here, Porpoise Positive Minutes) shall account for the acoustic environments where probability of detecting signals may be affected by variability in ambient noise levels.
Design on Big data Platform-based in Higher Education Institute

According to a continuously increasing amount of information in all aspects whether the sources are retrieved from an internal or external organization, a platform should be provided for the automation of whole processes in the collection, storage, and processing of Big Data. The tool for creating Big Data is a Big Data challenge. Furthermore, the security and privacy of Big Data and Big Data analysis in organizations, government agencies, and educational institutions also have an impact on the aspect of designing a Big Data platform for higher education institute (HEi). It is a digital learning platform that is an online instruction and the use of digital media for educational reform including a module provides information on functions of various modules between computers and humans. 1) Big Data architecture is a framework for an architecture of numerous data which consisting of Big Data Infrastructure (BDI), Data Storage (Cloud-based), processing of a computer system that uses all parts of computer resources for optimal efficiency (High-Performance Computing: HPC), a network system to detect the target device network. Thereafter, according to Hadoop’s tools and techniques, when Big Data was introduced with Hadoop's tools and techniques, the benefits of the Big Data platform would provide desired data analysis by retrieving existing information, to illustrate, student information and teaching information that is large amounts of information to adopt for accurate forecasting.
Energy‐optimal transport trajectory planning and online trajectory modification for holonomic robots

To maximize energy efficiency, we suggest minimum‐energy trajectory planning and online trajectory modification algorithms for three‐wheeled omni‐directional mobile robots (TOMRs). First, minimum‐energy multisection trajectory planning for various constraints is performed using Pontryagin's minimum principle. Two strategies are established to formulate an efficient minimum‐energy, multisection trajectory generation algorithm: an online trajectory modification and a control algorithm that maintains energy efficiency are investigated using novel heuristic functions. Compared with the conventional trajectory using the trapezoidal velocity profile, the generated transport trajectory can save energy.
Molecular adaptation of mercuric reductase to hypersaline environments

APA Citation Ramadan, E. (2017). Molecular adaptation of mercuric reductase to hypersaline environments [Doctoral Dissertation, the American University in Cairo]. AUC Knowledge Fountain. https://fount.aucegypt. edu/etds/1 MLA Citation Ramadan, Emanbellah. Molecular adaptation of mercuric reductase to hypersaline environments. 2017. American University in Cairo, Doctoral Dissertation. AUC Knowledge Fountain. https://fount.aucegypt. edu/etds/1
Data Collection Protocols in Wireless Sensor Networks

In recent years, wireless sensor networks have became the effective solutions for a wide range of IoT applications. The major task of this network is data collection, which is the process of sensing the environment, collecting relevant data, and sending them to the server or BS. In this chapter, classification of data collection protocols are presented with the help of different parameters such as network lifetime, energy, fault tolerance, and latency. To achieve these parameters, different techniques such as multi-hop, clustering, duty cycling, network coding, aggregation, sink mobility, directional antennas, and cross-layer solutions have been analyzed. The drawbacks of these techniques are discussed. Finally, the future work for routing protocols in wireless sensor networks is discussed.
El efecto mediador del ajuste psicológico en la relación entre la victimización por acoso escolar y el sentido de pertenencia escolar

Desde el ámbito educativo, el sentido de pertenencia escolar ha suscitado el interés de los investigadores, por su influencia en el rendimiento y el éxito académico, y más recientemente, se ha asociado con la salud mental, el bienestar social y el ajuste psicológico de los adolescentes. Sin embargo, es escaso el conocimiento de la relación entre los procesos de victimización por acoso escolar, el sentido de pertenencia y el papel mediador que puede desempeñar el ajuste psicológico. Es por ello que nos planteamos este estudio, en el que participaron 140 adolescentes con edades entre 12 y 16 años, a los que se les aplicó una batería de medidas de acoso escolar, ajuste psicológico y pertenencia escolar. Los resultados confirmaron un modelo de ecuaciones estructurales, en el que el factor de victimización por acoso psicológico predice el sentido de pertenencia escolar de manera directa e indirecta, a través del ajuste psicológico (indicadores de alteraciones emocionales y de ajuste escolar). Ni la exclusión ni el acoso relacional mostraron efectos directos o indirectos sobre el sentido de pertenencia. Atendiendo a las limitaciones del estudio, se discute la importancia de fomentar el sentido de pertenencia en la escuela como un factor protector frente al acoso escolar.
Pulmonary Vein Activity Organization to Determine Atrial Fibrillation Recurrence: Preliminary Data from a Pilot Study

Ablation of pulmonary veins has emerged as a key procedure for normal rhythm restoration in atrial fibrillation patients. However, up to half of ablated Atrial fibrillation (AF) patients suffer recurrences during the first year. In this article, simultaneous intra-atrial recordings registered at pulmonary veins previous to the ablation procedure were analyzed. Spatial cross-correlation and transfer entropy were computed in order to estimate spatial organization. Results showed that, in patients with arrhythmia recurrence, pulmonary vein electrical activity was less correlated than in patients that maintained sinus rhythm. Moreover, correlation function between dipoles showed higher delays in patients with AF recurrence. Results with transfer entropy were consistent with spatial cross-correlation measurements. These results show that arrhythmia drivers located at the pulmonary veins are associated with a higher organization of the electrical activations after the ablation of these sites.
Preparation and application of sulfonated polysulfone in an electrochemical hydrogen storage system

Storage of hydrogen in/on solid‐state materials is predicted from their tendency to adsorb‐desorb hydrogen. It is crucial to find a new class of materials that can reversibly store hydrogen at high rates under reasonable temperature, pressure, and cost conditions. Polymeric materials have recently come to the fore of hydrogen storage technologies because of their reversible capacity, approximately high surface area, and thermomechanical stabilities. Here, we report, for the first time, a polymer for hydrogen storage based on sulfonated polysulfone (SPSU) of above 500 mAh g−1 (~1.8 wt% H) of discharge capacity. Primarily, the SPSU have polymerized from polysulfone (PSU) in the presence of chlorosulfonic acid (ClSO3H). The spectroscopic and elemental analyses confirm the successful sulfonation of PSU. The electrochemical properties of the sample illustrate at high frequency, the resistance is small with slopes of around zero. Cyclic voltammetry affirms a quick ion transfer ability of the host polymer owing to the ion diffusion reaction within the working electrodes. The charge‐discharge efficiency of this system exhibits a stable sequence with around 93% efficiency, comparable with many benchmark commercial batteries. The results clearly emphasize that the SPSU can be individually assigned for hydrogen storage. This study will promote the technology of hydrogen sorption on organic polymers.