Miracle-dz/UniFAR-FTUs huggingface dataset:
ESPECIES VEGETALES INVESTIGADAS POR SUS PROPIEDADES ANTIMICROBIANAS, INMUNOMODULADORAS E HIPOGLICEMIANTES EN EL DEPARTAMENTO DE CALDAS (COLOMBIA, SUDAMÉRICA)

The use of medicinal herbage plants with therapeutic purposes in the primary health careattention of the health, is a frequent practice in the Colombian coffee zonetriangle. Our research line group has done carried out some ethnopharmacologic studies in this zone, selecting some vegetal species to evaluate the possible antimicrobial, immunomodulating and hypoglycemic activity. The present review describes the nine species studied, with a short brief botanic description, common names, traditional empiric uses, phytochemistry, and emphasizing in on the biological activity found in the literature or in our assaysresearch. The findings of this review establish that, in this region environment, the medical use of plants is a habitual usual practice, with different indications for a the same vegetal species (a lot of them do notnot even validated scientifically), not always match the uses in different regions of common ethnic or culture cultural common ancestry not always match and even less in dispersewhen there are different ancestry regions; sometimes the experimental result does not validate the tradicional and empiric therapeutic indication but before to stablishestablishing such this indication as invalid, several pre-clinic and clinic trials must be carried out in order toshould be done some preclinical and clinical assays to search for the efficacy and safety. Due to the enormous biodiversity of Colombian flora it would be thought that there is have an extensive research about their its pharmacology and phytochemistry, but really there are a very few species validated by chemical and biological studies. ; forFor this reason, there are very low medical and economic exploitation of this flora. In our country only a few Universities promote the research in this field and have not support of the pharmaceutical industry or of the government or private agencies is not observed. By Because of political and cultural reasons, the Indian indigenous communities are reluctant to share his their ancestral empiric ethnopharmacologic knowledgment knowledge with other social groups. Five species shown showed promissory immunostimulant activity by increasing leukocyte counts:. Alternanthera williamsii (Standley) Standley var. purpurea, Amaranthaceae family, Ludwigia polygonoides H.B. K. , Onagraceae family, Phenax rugosus (Poir.) Wedd, Urticaceae family, Solanum dolichosepalum Bitter, Solanaceae family and Tabebuia chrysantha (Jacq) Nichols, Bignoniaceae family; five species: Alternanthera williamsii (Standley) Standley var. purpurea, Ludwigia polygonoides H.B. K. , Austroeupatorium inulaefolium (H.B.K.) R. M. King & H. Rob. , Senna reticulata (Willd) H. Irwin and Solanum dolichosepalum Bitter, have some important antibacterial effect on Staphylococcus aureus, Escherichia coli y Pseudomona aeruginosa.
Exploring the mechanisms of fibrillar protein aggregation

The aim of this thesis is to investigate and better understand the mechanisms of protein self-assembly. Specifically, I study three protein systems which form morphologically and structurally distinct fibrillar protein aggregates. The first of these studies is concerned with the self-assembly of amyloid fibrils formed from bovine insulin. Amyloid fibrils are associated with human diseases such as Alzheimers Disease and type-2 diabetes, and are also garnering interest in biomaterial applications. Fragmentation-dominated models for the self-assembly of amyloid fibrils have had important successes in explaining the kinetics of amyloid fibril formation but predict fibril length distributions that do not match experimental observations. Here I resolve this inconsistency using a combination of experimental kinetic measurements and computer simulations. I provide evidence for a structural transition demarcated by a critical fibril mass concentration, or CFC, above which fragmentation of the fibrils is suppressed. Our simulations predict the formation of distinct fibril length distributions above and below the CFC, which I confirm by electron microscopy. These results point to a new picture of amyloid fibril growth in which structural transitions that occur during self-assembly have strong effects on the final population of aggregate species with small, and potentially cytotoxic, oligomers dominating for long periods of time at protein concentrations below the CFC. I further show that the CFC can be modulated by environmental conditions, pointing to possible in vivo strategies for controlling cytotoxicity. I probe the structural nature of the transition by performing small angle neutron scattering. Secondly, I study the formation of amyloid-like fibrils from the protein ovalbumin. I undertake kinetic experiments of self-assembly and find two key features emerge: the lack of a lag time and the existence of a slow growth regime in the long-time limit. I observe, using TEM, that these fibrils are worm-like in
Yield, fruit quality, bud fertility and starch reserves of the wood as a function of leaf removal in Vitis vinifera - evidence of compensation and stress recovering.

Einflus unterschiedlicher Entblatterung auf Ertrag, Traubenqualitat, Knospenfruchtbarkeit und Starkegehalt des Holzes von Vitis vinifera sowie Kompensations- und Erholungsvermogen An Ertragsreben wurde der Einflus des Entfernens von Hauptblattern oder Geiztrieben auf Gesamtblattflache, Traubenertrag und -qualitat sowie Starkegehalt des Holzes studiert. Die Bedeutung von Haupt- und Geizblattern sowie des Zeitpunktes der Entblatterung auf dss Verrieseln wurde untersucht. Ziel der Studie war, Kompensationsmechanismen und -limiten der Rebe unter Stresbedingungen kennenzulernen, wie sie durch eine Entblatterung verursacht werden. Ferner sollte die Erholung der Pflanze nach langerer Streseinwirkung erforscht werden. Wurden die Hauptblatter entfernt (L = nur Geizblatter}, so bildeten die Pflanzen mehr Geiztriebe mit einer groseren Anzahl Blatter. Dies fuhrte nach dem ersten Stresjahr zu einer ungefahr gleichen Gesamtblattflache wie bei den Kontrollpflanzen. Nach einem weiteren Stresjahr jedoch hatten die L-Pflanzen zwar weiterhin mehr Geizblatter, allerdings von geringerer Grose. Hieraus resultierte eine im Vergleich zur Kontrolle verringerte Gesamtblattflache. Pflanzen nur mit Hauptblattern (M) kompensierten das Fehlen der Geiztriebe mit verzogerter Blattalterung und spaterem Blattfall. Auch hier ergab sich nach dem zweiten Stresjahr eine geringere Blattgrose. Der Traubenertrag der L-Pflanzen wurde im 1. Jahr durch die Blattentfernung kaum negativ beeinflust, aber im 2. Jahr war er 50 % niedriger als in der Kontrolle. Bei den M-Pflanzen ergab sich in beiden Jahren kein verringerter Ertrag. Der Zuckergehalt der Trauben war in den L-Pflanzen im 1. Stresjahr leicht erhoht, nicht aber im 2. Jahr. Diese Reben hatten wahrend beider Jahre eine bessere Beerenfarbe. Die Blattflache vom Zeitpunkt der Blute bis 2-3 Wochen danach ist fur den Traubenertrag entscheidend. Eine Entblatterung zu diesem Zeitpunkt verursachte nicht nur ein Verrieseln, sondern im folgenden Jahr zusatzlich eine reduzierte Knospenfruchtbarkeit. Die Zuckereinlagerung in den Trauben hangt von der assimilierenden Blattflache wahrend der Reifeperiode ab. Der Starkegehalt im Holz war nach 2 Stresjahren erheblich reduziert. Es ergaben sich schwach positive Korrelationen zwischen Zuckergehalt des Mostes und Starkegehalt des Holzes. Die Zuckereinlagerung in die Traube und das Auffullen der Starkereserven im Holz ging bereits in der auf eine Stresbehandlung folgenden Saison normal vonstatten. Ein normaler Ertrag war l Jahr nach einem langeren Entblatterungsstres jedoch noch nicht moglich, da die Bildung der Infloreszenzen bekanntlich wahrend dieser Zeit (in unserem Fall die Stresperiode) einsetzt. Erst im 2. Jahr kam es zu einer vollstandigen Erholung der Pflanze.
Dynamic Energy and Thermal Management of Multi-core Mobile Platforms: A Survey

Editor’s notes: Multicore mobile processors have proliferated due to their efficiency in meeting the stringent performance requirement within a limited power budget. However, their continued success depends critically on managing their power and performance in the presence of dynamic workload variations. This article provides a survey of dynamic energy and thermal management approaches for multicore mobile platforms and discussed open challenges. —Umit Y. Ogras, Arizona State University
General Extrapolation Spaces and Perturbations of Bi-Continuous Semigroups

A lot of well-known partial differential equations modeling physical systems, such as the heat equation, the Schrodinger equation or the wave equation, use temporal change of states. Evolution equation is an umbrella term for such equations that can be interpreted as differential laws describing the development of a system or as a mathematical treatment of motion in time. With a solution of an evolution equation, one can predict the future of the corresponding physical system which makes it deterministic. Evolution equations can be treated by an operator theoretical approach. They can be rewritten as so-called abstract Cauchy problems which are connected to strongly continuous operator semigroups on Banach spaces. However, Stochastic differential equations, Ornstein–Uhlenbeck processes or Feller processes, give rise to transition semigroups which are in general not strongly continuous. Here bi-continuous semigroups come into play, which form in fact the key subject of this thesis. The research on bi-continuous semigroups was motivated by the work of F. Kuhnemund. In fact, she was the initiator for the development of the theory of bi-continuous semigroups. The main idea is to equip the underlying Banach space, on which the corresponding semigroup fails to be strongly continuous with respect to the norm, with an additional locally convex topology, which is compatible with the norm topology, such that the semigroup becomes strongly continuous with respect to this locally convex topology. The work of F. Kuhnemund was followed by research by B. Farkas. He investigated perturbation theory for bi-continuous semigroups. In this thesis we introduce the concept of bi-continuous semigroups and the underlying structure, study the construction of extrapolation and intermediate spaces of non-densely defined operators, discuss different perturbation type theorems for bi-continuous semigroups and consider flows on networks in connection with bi-continuous semigroups.
Assessment of the influence of FDI on the economic growth of the host country: evidence from Kazakhstan

The article examines the impact of FDI inflows on the economic growth of the host country, using the Kazakhstan economy as an example. The authors attempted to assess the impact of FDI using a multiple regression model. As a measure of economic growth, Kazakhstan’s GDP data for the period 2000-2017 was used. The simulation results didn’t reveal the negative impact of FDI on economic growth, but the analysis revealed that the presence of a positive relationship is not essential for assessing the growth of the national economy.
An Integrated SRM Powertrain Topology for Plug-In Hybrid Electric Vehicles With Multiple Driving and Onboard Charging Capabilities

Plug-in hybrid electric vehicles (PHEVs) possess the merits of low carbon emissions, high fuel efficiency, and long driving mileage, and thus attract more and more attention. This article presents an integrated switched reluctance motor (SRM) powertrain topology for PHEVs, which owns multiple driving and battery-charging functions with less power electronic devices than traditional topology. In motor driving mode, four driving modes are achieved according to the road conditions. Motoring and braking operations can be successfully implemented. For battery-charging mode, three charging modes are implemented without extra battery chargers. A three-channel interleaved boost converter with power factor correction (PFC) capability is constituted by utilizing the SRM windings and integrated converter circuit to charge the traction battery from the grid. An integrated half-bridge isolation dc/dc converter is employed to charge the auxiliary battery from the generator or traction battery. A proof-of-concept prototype platform is built and experiments are carried out on a three-phase 12/8 poles SRM to verify the effectiveness of the proposed integrated drive topology and the corresponding control schemes.
A contribuição das redes sociais, Facebook e Instagram, para a captação de clientes no segmento de barbearias em Manaus

Redes sociais oferecem vantagens quando utilizadas como ferramentas de marketing digital para empresas, pois possuem potencial para atrair pessoas para marcas, produtos e servicos. Neste sentido, este estudo teve por objetivo identificar como as barbearias de Manaus estao se beneficiando da comunicacao por meio do Facebook e Instagram. Para isto, utilizou-se da pesquisa aplicada, com objetivos quantitativo-descritivos, a qual fez uso de levantamento bibliografico e de campo, com aplicacao de questionario online e presencial, contendo 19 perguntas fechadas, em 15 barbearias de Manaus. Os resultados encontrados mostraram que, para obter um bom desempenho nas redes sociais e, com isso, gerar aumento na receita em vendas, nao precisam investir recursos financeiros diretamente em marketing nas redes sociais, mas sim investir em tempo para criacao de conteudo de qualidade e na interacao virtual com os clientes.
Great tits can reduce caterpillar damage in apple orchards

1.The potential contribution of vertebrate predators to biological control in orchards has been largely overlooked to date. A few studies have shown that birds reduce numbers of pests, but data are scarce on the effects on the pattern or timing of damage. Consequently, the practical value of birds as biocontrol agents remains unclear. 2. This study considered whether great tits Parus major can reduce caterpillar numbers and fruit damage by caterpillars, and increase biological yield, in an experimental orchard of apple trees with high caterpillar numbers. The outcome would depend on the coincidence of the period during which great tits forage and the period during which caterpillars cause damage. In the first experiment nets were put over trees at different times of the growing season, thus creating different periods during 3. The longer the period of foraging by great tits, from the start of egg incubation until fledging of young, the less the overall pest damage to fruit. Damage caused by caterpillars was greater the later they were removed, from the young apple stage onwards. 4. The effect of great tits on caterpillar damage to apples was small (percentage damage was reduced from 13·8% to 11·2%) but significant (P <0·05), and the yield of fruit increased significantly (from 4·7 to 7·8 kg apples per tree, P<0·05). The only cost to the producer was that of erecting nest boxes (c. 2 ha1) to encourage great tits to breed in the orchard. Depending on the great tits' numeric response to insect densities, their relative impact may be greater at lower densities more typi
Prediction of the failure mode of automotive steels resistance spot welds

In this study, the critical nugget size, at which the failure state in tensile shear test changed from the interfacial failure mode to the pull-out failure one, was estimated as a function of nugget and base metal hardness. The proposed approach could address the effect of various parameters involved in resistance spot welding process, such as sheet thickness, base metal chemical composition and physical properties of electrodes and sheets. The reliability of the present model was evaluated using independent experimental results. Based on the obtained results, the effect of steel composition on critical nugget diameter was found to be more important, especially for the sheets thicker than about 1 mm, whereas predicted nugget sizes by previous models could not guarantee the pull-out failure mode.
IN VITRO STORAGE OF PAULOWNIA TOMENTOSA

Storage of plant species with high commercial potential as ornamental or for the alimentation and pharmacological has been used to preserve genetic variability and allowed the study of its properties in a controlled environment through the use of in vitro culture techniques. In this study, shoot tip explants of Paulownia tomentosa were excised from in vitro grown shootlets and cultured on Murashige and Skoog (MS) medium supplemented with 30 g l-1 sucrose (control) and different concentrations of sucrose or sorbitol (20, 40, 50 and 60 g l-1) and in combinations (10 + 10, 20 + 20, 25 + 25 and 30 + 30 g l-1) and incubated under 18 °C in complete darkness for 2, 4, 6, 8 and 10 months. Results showed that all shoot tip explants conserved on MS medium augmented with different concentrations of sucrose or sorbitol and their combinations for 2 months, at the level of 30 g l-1 sucrose (control) for 4 months recorded the best survival percentage (100%). At the end of storage period (after 10 months), the highest survival percentage (83.33%) was noticed when explants were conserved on MS medium with 30 g l-1 (control) or 50 g l-1 sucrose. Meanwhile, the lowest survival percentage (25.00%) was achieved when explants were conserved on MS medium with 10 g l-1 sucrose + 10 g l-1 sorbitol. Moreover, it was observed an increasing of shoot length and number of proliferated shoots/explant during storage periods except all treatments with sorbitol and the treatment with sucrose plus sorbitol (10 + 10 g 1-1) remained without change in all storage periods.
A Large-Dimensional Test for Cross-Sectional Anomalies: Efficient Sorting Revisited

Many researchers seek factors that predict the cross-section of stock returns. In finance, the key is to replicate anomalies by long-short portfolios based on their factor scores, with microcaps alleviated via New York Stock Exchange (NYSE) breakpoints and value-weighted returns. In econometrics, the key is to include a covariance matrix estimator of stock returns for the (mimicking) portfolio construction. This paper marries these two strands of literature in order to test the zoo of cross-sectional anomalies by injecting size controls, basically NYSE breakpoints and value-weighted returns, into efficient sorting. Thus, we propose to use a covariance matrix estimator for ultra-high dimensions (up to 5,000) taking into account large, small and microcap stocks. We demonstrate that using a nonlinear shrinkage estimator of the covariance matrix substantially enhances the power of tests for cross-sectional anomalies: On average, ‘Student’ t-statistics more than double.
Downstream of Kinase, p62dok, Is a Mediator of FcγRIIB Inhibition of FcεRI Signaling1

The low-affinity receptor for IgG, FcγRIIB, is expressed widely in the immune system and functions to attenuate Ag-induced immune responses. In mast cells, coaggregation of FcγRIIB with the high-affinity IgE receptor, FcεRI, leads to inhibition of Ag-induced degranulation and cytokine production. FcγRIIB inhibitory activity requires a conserved motif within the FcγRIIB cytoplasmic domain termed the immunoreceptor tyrosine-based inhibition motif. When coaggregated with an activating receptor (e.g., FcεRI, B cell Ag receptor), FcγRIIB is rapidly phosphorylated on tyrosine and recruits the SH2 domain-containing inositol 5-phosphatase (SHIP). However, the mechanisms by which SHIP mediates FcγRIIB inhibitory function in mast cells remain poorly defined. In this report we demonstrate that FcγRIIB coaggregation with FcεRI stimulates enhanced SHIP tyrosine phosphorylation and association with Shc and p62dok. Concurrently, enhanced p62dok tyrosine phosphorylation and association with RasGAP are observed, suggesting that SHIP may mediate FcγRIIB inhibitory function in mast cells via recruitment of p62dok and RasGAP. Supporting this hypothesis, recruitment of p62dok to FcεRI is sufficient to inhibit FcεRI-induced calcium mobilization and extracellular signal-regulated kinase 1/2 activation. Interestingly, both the amino-terminal pleckstrin homology and phosphotyrosine binding domains and the carboxyl-terminal proline/tyrosine-rich region of p62dok can mediate inhibition, suggesting activation of parallel downstream signaling pathways that converge at extracellular signal-regulated kinase 1/2 activation. Finally, studies using gene-ablated mice indicate that p62dok is dispensable for FcγRIIB inhibitory signaling in mast cells. Taken together, these data suggest a role for p62dok as a mediator of FcγRIIB inhibition of FcεRI signal transduction in mast cells.
Effects of Mannan Oligosaccharides and/or Bifidobacterium on Growth and Immunity in Domestic Pigeon (Columba livia domestica)

The goal of this study was to evaluate the influences of mannan oligosaccharides (MOSs) and/or Bifidobacterium on the growth and immunity of pigeons over a 56-day period. One hundred paired adult pigeons were randomly divided into four groups of five paired pigeons. Paired pigeons with two young squabs were housed in a man-made aviary. Parent pigeons in the control group received a basal diet (C), while the other three groups were fed with the basal diet supplemented with 20 g of MOSs/kg of feed (M), 10 g Bifidobacterium (1×1010 CFU/g)/kg of feed (B), or a combination of M and B (MB). We found higher body weights (BW) in pigeons of the B group than in the C, M, and MB groups. None of the treatments exerted significant effects involving spleen and thymus indices, whereas M birds tended to improve the bursa of Fabricius index. Pigeons fed with the M-supplemented diet exhibited improved serum immunoglobulin M (IgM) concentrations compared with those fed with C and the B- and MB-supplemented diets. In addition, M treatment increased immunoglobulin A (IgA) levels compared with MB treatment. MB treatment improved serum immunoglobulin G (IgG) concentrations compared to that by the C treatment. The concentration of secretory immunoglobulin A (sIgA) was significantly reduced in the duodenum and increased in the ileum in pigeons fed with the MB-supplemented diet. This study indicated that dietary supplementation with Bifidobacterium increased the growth performance. Dietary supplementation with MOSs or in combination with Bifidobacterium was able to improve immune function in pigeons but exerted no apparent effect on weight gain. Accordingly, in terms of economic benefits, the findings suggested that supplementation with Bifidobacterium alone may improve production performance, and that supplementation with MOSs alone may improve immune function in pigeons.
Time as a source of struggle and resilience in homeless families

A common myth about families living in homeless shelters is that they are laconically and contentedly waiting around for housing, financial support through welfare or jobs, and other resources and services. Nothing could be further from the truth. Single parents in shelters dealing with inequities incurred by poverty are busy trying to procure housing, jobs, and other resources while managing children’s behavior and homework, and while attempting to maintain the family’s sense of relational and emotional integrity. Thirty-six African American, Afro-Caribbean, and Latinx families living in a New York City shelter were interviewed about the time challenges they face and their means of coping with those challenges. Six themes emerged: (1) franticness, time pressure, and sense of having not enough time; (2) the temporal unpredictability of daily life; (3) the unpredictability of time to live in shelter; (4) anxious waiting for next steps toward employment and housing; (5) the shelter’s control of time; and (6) the importance of family time and strategies used to sustain it. These findings are discussed using theoretical perspectives about the elements of temporal behavior, as well as research on time and personal agency, and recommendations are made for professionals working to support homeless families, especially around their temporal challenges.