Miracle-dz/UniFAR-FTUs huggingface dataset:
dolescent Alcohol Initiation : A Review of sychosocial Risk Factors

f s g a t i t c s u u t w f i Abstract: Longitudinal research studies focused on lcohol use initiation in adolescence were reviewed to etermine which variables function as antecedent predicors or risk factors. Only studies that focused on time-1 bstainers were included. Classes of risk factors examned include sociodemographic, family, peer, personalty, and behavioral variables. The most consistent anteedent risk factors for starting to drink in adolescence ere parental and peer approval and models for drinking nd drug use as well as adolescents’ own prior involveent in delinquent behavior. There was little evidence or gender differences in risk factors for alcohol use nitiation. Secondary analyses of existing longitudinal ata sets are encouraged to examine whether there are thnic/racial differences in the risk factors for starting to rink and to establish those factors that serve a protective r buffering function, delaying onset of alcohol use in dolescence. © Society for Adolescent Medicine, 2004
Carp Muscle Calcium-binding Protein 11 . STI 1 UCTUR

The structure of crystalline carp muscle calcium-binding protein (parvalbumin) has been determined by x-ray diffraction techniques to nominal 1.85-A resolution. Isomorphous and anomalous scattering data were measured for three heavy atom derivatives, 3-chloromercuri-2-methoxypropyl urea, mercury bromide, and ethyl mercury chloride, to 2.0-A resolution using precession photography. As described in Paper III in this series the 2.0-A phases were refined and the 2.0to 1.85-A phases were determined by use of the tangent formula. The electron density map is interpreted in terms of the 108 amino acid sequence described in Paper I in this series. A calcium ion is bound in the loop between helix C and helix D and a second calcium is bound in the EF loop. The entire CD region is related to helix E, the EF loop, and the terminal helix F by an approximate intramolecular 2-fold axis. Although it does not bind calcium the AB region has a structure similar to the CD and EF regions and appears to have resulted from a gene triplication. The molecule is generally spherical with a well defined hydrophobic core, one-seventh of its total volume, composed of side chains of phenylalanine, isoleucine, leucine, and valine. All of the polar side chains are at the surface except those associated with calcium binding and with an invariant internal salt bridge between arginine-75 and glutamic acid-81.
La chimie du brome appliquée à la désinfection des eaux de piscines : étude bibliographique

Cet article presente une revue bibliographique sur la desinfection des eaux de piscines par le brome, sur les mecanismes de formation et le mode d'action du desinfectant, l'acide hypobromeux. L'examen des principaux sous-produits de bromation (bromamines, trihalomethanes, acides haloacetiques, haloacetonitriles, haloaldehydes, bromate, nitrosamines, etc.) montre que certains de ces sous-produits sont presents dans l'eau de piscine a des concentrations de quelques µg∙L-1 a quelques dizaines de µg∙L-1. L'etude de leur toxicite aigue et chronique confirme que ces composes doivent etre surveilles (en particulier l'acide dibromoacetique et le bromate) pour assurer la securite des nageurs et du personnel technique. D'autre part, l'etude de l'efficacite biocide du brome compare au chlore, vis-a-vis des bacteries pathogenes presentes dans l'eau de piscine, demontre que les especes de bacteries Escherichia coli et Enterococcus faecalis sont plus sensibles au brome, a la difference de Pseudomonas aeruginosa qui presente une plus grande resistance. De plus, sur le plan medical, plusieurs cas de dermatites de contact irritantes sont rapportes lors de l'utilisation du brome, meme si certaines etudes revelent que les bromamines sont non irritantes, inodores et desinfectantes. Cependant, le brome presente une plus grande activite bactericide que le chlore dans des eaux legerement alcalines et relativement chaudes et peut etre alors une alternative au chlore dans le traitement des piscines atypiques, meme s'il demeure beaucoup plus onereux que le chlore.
The Study of Relationship among Project Management and Implementation Performance of ERP

This paper explores the relationships between the achievement of project management and the degree of implementation performance of Enterprise Resource Planning(ERP). In this paper, DeLone & McLean’s (1992) information systems (IS) success framework will be used to develop the implementing ERP systems performance measures for assessing project management and enterprises’ performance improvement in the post-implementation stage.
Optimal preventive maintenance interval and spare parts number in a rolling stock system

In this paper, we deal with a preventive maintenance (PM) scheduling and spare parts problems for a rolling stock system. We determine the optimal PM interval and the optimal number of spare parts for components in the rolling stock system to minimize the system life cycle cost during satisfying the system target availability. The system availability and system life cycle cost are estimated by simulation. A genetic algorithm and a simulated annealing are proposed to find the optimal PM intervals and the optimal spare parts number of all components. Numerical examples are also studied.
Anglicismos sexuales en español: El inglés como recurso eufemístico y disfemístico en la comunicación virtual

Dentro del marco general de la interdiccion linguistica y partiendo de los paradigmas del analisis del discurso y la linguistica cognitiva, este libro aborda el funcionamiento del anglicismo sexual en el foro de internet, un modo de comunicacion espontaneo y cercano a la comunicacion oral informal cuyo caracter anonimo favorece la aparicion de cuestiones intimas. Asi, tomando como corpus los mensajes procedentes de dos comunidades virtuales en lengua espanola de tematica sexual, en este trabajo se examinan los valores eufemisticos y disfemisticos que presentan los anglicismos en sus distintas variantes (puros, adaptados, hibridos, calcos y pseudoanglicismos) dentro de las areas tematicas, sujetas a mayor o menor grado de estigma social, en las que incide el tabu del sexo (estereotipos, eventos y espectaculos, homosexualidad, lugares relacionados con el sexo, partes del cuerpo, pornografia y sadomasoquismo, practicas y relaciones, prostitucion y vestimenta y objetos). El analisis practicado a mas de un millar de lexias anglicadas revela una notable presencia del anglicismo, que desempena distintas funciones comunicativas en la expresion del tabu sexual: desde la atenuacion a la ofensa pasando por la cohesion grupal, la camaraderia o la provocacion. Ademas, el anglicismo utilizado para hablar de sexo, especialmente el de naturaleza metaforica, contribuye a desvelar las intenciones subyacentes al uso de las lexias de origen ingles asi como las actitudes y juicios de valor de los usuarios de los foros.
Preserving data privacy with Searchable Symmetric Encryption

New techniques such as Searchable Encryption are being deployed to enable data to be encrypted online. Searchable Encryption is now at the point that it can be deployed and used within the Cloud. In the Cloud, Searchable Encryption has the ability to allow CSP customers to store their data in encrypted form, while retaining the ability to search that data without disclosing the associated decryption key(s) to CSPs that is, without compromising data security on the Server. We present an SSE scheme and evaluate the efficiency of storing and retrieving data from the cloud. The results showed that carrying out a task using SSE is directly proportional to the amount of information involved.
Generating Representative Sets and Summaries for Large Collection of Images Using Image Cropping Techniques and Result Comparison

The collection of photos hosted on photo archives and social networking sites has been increasing exponentially. It is really hard to get the summary of a large image set without browsing through the entire collection. In this paper two different techniques of image cropping (random windows technique and sequential windows technique) have been proposed to generate effective representative sets. A ranking mechanism has been also proposed for finding the best representative set.
Color: Implications in dentistry

The success of restorative dentistry is determined on the basis of functional and esthetic results. To achieve esthetics, four basic determinants are required in sequence; viz., position, contour, texture and color. The knowledge of the concept of color is essential for achieving good esthetics. This review compiles the various aspects of color, its measurements and shade matching in dentistry.
Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity

Fragmentation of various extracellular matrix and blood proteins generates antiangiogenic substances that are physiological regulators of angiogenesis. Some of these compounds are in clinical trials as inhibitors of tumor angiogenesis. Anastellin, an antiangiogenic protein fragment derived from fibronectin, was unable to inhibit matrigel plug angiogenesis in mice that lack plasma fibronectin. Anastellin was fully active in mice that are null for vitronectin, which, like fibronectin, is a major adhesion protein in the blood. An antiangiogenic form of antithrombin showed the opposite pattern. The activity of endostatin was impaired in both fibronectin- and vitronectin-deficient mice. These results suggest a shared mechanism of action for antiangiogenic factors derived from extracellular matrix and plasma proteins: these factors form complexes with adhesion proteins in plasma to create an active antiangiogenic substance.
Pseudorabies virus gene encoding glycoprotein gIII is not essential for growth in tissue culture

We have established that in the Becker strain of pseudorabies virus (PRV), the glycoprotein gIII gene is not essential for growth in cell culture. This was accomplished by construction and analysis of viral mutants containing two defined deletion mutations affecting the gIII gene. These mutations were first constructed in vitro and introduced into Escherichia coli expression plasmids to verify structure and protein production. Each mutation was then crossed onto PRV by cotransfection of plasmid DNA and parental viral DNA by using gIII-specific monoclonal antibodies as selective and screening reagents. One resultant virus strain, PRV-2, contained an in-frame deletion of a 402-base-pair (bp) SacI fragment contained within the gIII gene. Another virus strain, PRV-10, contained a deletion of a 1,480-bp XhoI fragment removing 230 bp of the upstream, putative transcriptional control sequences and 87% of the gIII coding sequence. The deletion mutants were compared with parental virus by analysis of virion DNA, gIII specific RNA, and proteins reacting with gIII specific antibodies. Upon infection of PK15 cells, the deletion mutants did not produce any proteins that reacted with two gIII specific monoclonal antibodies. However, two species of truncated glycosylated proteins were observed in PRV-2 infected cells that reacted with antiserum raised against bacterially produced gIII protein. PRV-10 produced no detectable gIII-specific RNA or protein. PRV-10 could be propagated without difficulty in tissue culture. Virus particles lacking gIII were indistinguishable from parental PRV virus particles by analysis of infected-cell thin sections in the electron microscope. We therefore conclude that expression of the gIII gene was not absolutely essential for PRV growth in tissue culture.
Involvement of FOXL2 and RSPO1 in Ovarian Determination, Development, and Maintenance in Mammals

In mammals, sex determination is a process through which the gonad is committed to differentiate into a testis or an ovary. This process relies on a delicate balance between genetic pathways that promote one fate and inhibit the other. Once the gonad is committed to the female pathway, ovarian differentiation begins and, depending on the species, is completed during gestation or shortly after birth. During this step, granulosa cell precursors, steroidogenic cells, and primordial germ cells start to express female-specific markers in a sex-dimorphic manner. The germ cells then arrest at prophase I of meiosis and, together with somatic cells, assemble into functional structures. This organization gives the ovary its definitive morphology and functionality during folliculogenesis. Until now, 2 main genetic cascades have been shown to be involved in female sex differentiation. The first is driven by FOXL2, a transcription factor that also plays a crucial role in folliculogenesis and ovarian fate maintenance in adults. The other operates through the WNT/CTNNB1 canonical pathway and is regulated primarily by R-spondin1. Here, we discuss the roles of FOXL2 and RSPO1/WNT/ CTNNB1 during ovarian development and homeostasis in different models, such as humans, goats, and rodents.
Assessment of atrioventricular junction ablation and DDDR mode-switching pacemaker versus pharmacological treatment in patients with severely symptomatic paroxysmal atrial fibrillation: a randomized controlled study.

BACKGROUND The purpose of the study was to evaluate the effect of AV junction ablation and pacemaker implantation on quality of life and specific symptoms in patients with paroxysmal atrial fibrillation (AF) not controlled by drugs. METHODS AND RESULTS We performed a multicenter, randomized, 6-month evaluation of the clinical effects of AV junction ablation and DDDR mode-switching pacemaker (Abl+Pm) versus pharmacological treatment in 43 patients with intolerable, recurrent paroxysmal AF of three or more episodes in the previous 6 months not controlled with three or more antiarrhythmic drugs. Before completion of the study, 3 patients in the drug group withdrew because of the severity of their symptoms and 1 patient assigned to the Abl+Pm group in whom the ablation procedure failed. At the end of the 6 months, the 21 patients of the Abl+Pm group who completed the study showed, in comparison with the 18 of the drug group, lower scores in the Living with Heart Failure Questionnaire (-51%, P=.0006), palpitations (-71%, P=.0000), effort dyspnea (-36%, P=.04), exercise intolerance score (-46%, P=.001), and easy fatigue (-51%, P=.02). The scores for rest dyspnea, chest discomfort, and NYHA functional classification were also lower (-56%, -50%, and -17%, respectively) in the Abl+Pm group, although not significantly. At the end of the study, palpitations were no longer present in 81% of the Abl+Pm group and in 11% of the drug group (P=.0000). AF was documented in 31 of 122 visits (25%) in the Abl+Pm group and in 9 of 107 examinations (8%) in the drug group (P=.0005); chronic AF developed in 5 (24%) and 0 (0%) in the two groups, respectively (P=.04). CONCLUSIONS In patients with paroxysmal AF not controlled by pharmacological therapy, Abl+Pm treatment is highly effective and superior to drug therapy in controlling symptoms and improving quality of life. The discontinuation of drug therapy exposes patients to further recurrences of paroxysmal AF and the risk of developing permanent AF.
A Flowchart for Rapid Technical Debt Management Decision Making

Technical debt is known as delaying certain software maintenance tasks during software development life cycle to meet development goals in a short run. Such compromise increases maintenance cost in a way like growing financial interest in later development of software life cycle. Despite all the negative impact induced by technical debt, enterprise architects have to leverage between incurring technical debts and meeting short-term customer and financial related goals while making the decision for whether to pay the technical debt. However, the decision making, management, and tracing for technical debt is never formalized and surprisingly done by ad hoc. This study is aimed for constructing a step-by-step decision making map which helps the decision makers consider all possible impact factors. More importantly, such standardized process would improve the efficiency, consistency, stakeholders’ communication, and documentation for technical debt handling throughout the software life-cycle. In order to evaluate the effectiveness of the proposed decision making map and the according practice, a survey is composed as the appendix of this research report. This preliminary work, although with resource constraint, is a great foundation to build on for further study.
xln23 from Streptomyces chattanoogensis UAH23 Encodes a Putative Enzyme with Separate Xylanase and Arabinofuranosidase Catalytic Domains

The xylanase gene xysA of Streptomyces halstedii JM8 was used to isolate a DNA fragment from a gene library of Pstf-digested chromosomal DNA of the lignocellulolytic actinomycete Streptomyces chattanoogensis CECT-3336. Nucleotide sequence analysis revealed a gene (xln23) encoding a bifunctional multi-modular enzyme bearing two independent xylanase and a-L-arabinofuranosidase domains separated by a Ser/Gly-rich linker. The N terminus of the predicted protein showed high homology to family F xylanases. The C terminus was homologous to amino acid sequences found in enzymes included in the glycosyl hydrolase family 62 and, in particular, to those of a-L-arabinofuranosidase AbsB from Streptomyces livi-dans. PCR and RT-PCR experiments showed that the nucleotide sequences corresponding to each domain are arranged as expected on the chromosomal DNA and that they are cotranscribed. To our knowledge, this is the first description of xylanase and arabinofuranosidase domains in a same open reading frame.
The Chaperoning Activity of hsp110

hsp110 is one of major heat shock proteins of eukaryotic cells and is a diverged relative of the hsp70 family. It has been previously shown that hsp110 maintains heat-denatured luciferase in a soluble, folding competent state and also confers cellular heat resistance in vivo. In the present study the functional domains of hsp110 that are responsible for its chaperoning activity are identified by targeted deletion mutagenesis using the DnaK structure as the model. The chaperoning activity of mutants is assessed based on their ability to solubilize heat-denatured luciferase as well as to refold luciferase in the presence of rabbit reticulocyte lysate. It is shown that these functions require only an internal region of hsp110 that includes the predicted peptide binding domain and two immediately adjacent C-terminal domains. It is also shown that although hsp110 binds ATP, binding can be blocked by its C-terminal region.
Biomarqueurs du syndrome cardiorénal Biomarkers of cardiorenal syndrome

Complex interactions existing between cardiac and renal diseases led to define 5 types of so-called cardiorenal syndromes. This classification is based on the organ primarily involved and the acute or chronic failure. The mutual impact of renal and cardiac functions makes it difficult to evaluate and manage patients with cardiorenal syndromes and worsen morbidity and mortality. This review seeks to discuss the place of biomarkers in diagnosis, management and follow-up of patients with cardiorenal syndromes. Biomarkers can be classified as functional (creatinine, cystatin C. . .) or lesional (neutrophil gelatinase-associated lipocalin, urinary cystatin C. . .) renal markers and functional (natriuretic peptides. . .) or lesional (troponin, fatty acid binding pro409 Pour citer cet article : Kuster N, Moréna M, Bargnoux AS, Leray H, Chenine L, Dupuy AM, Canaud B, Cristol JP. Biomarqueurs du syndrome cardiorénal. Ann Biol Clin 2013 ; 71(4) : 409-18 doi:10.1684/abc.2013. 0877 rticle reçu le 24 décembre 2012, ccepté le 05 avril 2013 tein) cardiac markers. A last kind of biomarkers reflects the dialogue between heart and kidney (renin-angiotensin-aldosteron-system, indicators of activation of arginine vasopressin system) or the systemic impact (inflammation, oxidative stress. . .). In order to evaluate accurately the complex interactions that are the basis of cardiorenal syndromes, a multi-marker approach seems nowadays necessary.
Accelerated Spike Resampling for Accurate Multiple Testing Controls

Controlling for multiple hypothesis tests using standard spike resampling techniques often requires prohibitive amounts of computation. Importance sampling techniques can be used to accelerate the computation. The general theory is presented, along with specific examples for testing differences across conditions using permutation tests and for testing pairwise synchrony and precise lagged-correlation between many simultaneously recorded spike trains using interval jitter.
Effect of dielectric aging on the behavior of a surface nanosecond pulsed dielectric barrier discharge

In this study, surface Dielectric Barrier Discharge (DBD) actuators powered by a nanosecond pulsed high voltage are investigated. The goal is to experimentally analyze the effect of dielectric aging on the electrical behavior of the discharge and the surface plasma morphology. The used actuator is made of two conducting electrodes separated by a thin dielectric made of polyimide and arranged asymmetrically. The active electrode is connected to a nanosecond pulsed high voltage power supply and the second electrode is grounded and encapsulated inside a dielectric material. The actuator is aged by using the surface DBD supplied continuously during 15 minutes with a voltage pulse of + 10 kV at a frequency of 1 kHz and a pulse width of 250 ns. The experimental results show the existence of two discharges during both rising and falling periods of the voltage for both virgin and aged actuators. After aging, a third discharge current component is observed during the voltage plateau due to the ignition of additional discharges, which enhance the energy per pulse. ICCD camera images indicate that the plasma layer extends further on the dielectric surface in the case of aged actuators. In addition, large and non-localized filaments appear during the voltage plateau after aging due to the non-homogenous positive space charge distribution that intensifies the electric filed locally.
Intrusion Detection System Using Weka Data Mining Tool

Traditional intrusion prevention techniques, such as firewalls, access control or encryption, have failed to fully protect networks and systems from increasing attacks.Therefore an intrusion detection system (IDS) has become an important component of security infrastructure and a key part of system defense to detect these attacks before they make a disaster in the system. In this paper, we are going to design an intrusion detection system using Weka Data Mining Software, to check the existence of intrusion, and classify it when detected, to know the type of intrusion, according to attack types, this will implemented in Weka 3.6 Software, with KDD CUP 99 intrusion detection dataset. We construct a system with a very accurate, flexible and effective results when compare with other systems
Design and Simulation of a Low-Actuation-Voltage MEMS Switch

This paper presents a low-actuation-voltage micro-electro-mechanical system (MEMS) capacitive shunt switch which has a very large bandwidth (4 GHz to 24 GHz). In this work, the isolation of MEMS switch is improved by adding two short high impedance transmission lines at the beginning and end of a coplanar waveguide (CPW). Simulating the switch demonstrates that a return loss (S11) is less than -26 dB for the entire frequency band, and perfect matching at 20 GHz in upstate position. A ramp dual pulse driver is also designed for reducing the capacitive charge injection for considering the reliability of the switch. The simulation results show that the shifting of voltage due to the capacitive charge is reduced by more than 35% of the initial value. Finally, the dynamic behavior of the MEMS switch is simulated by modal analysis and using CoventorWare to calculate the natural frequencies of the switch and its mode shapes. The switching ON and OFF time are 4.48 and 2.43 μs, respectively, with an actuation voltage of less than 15 V.