Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical Article Hypertrophic olivary degeneration after surgical removal of cavernous malformations of the brain stem: report of four cases and review of the literature

Summary Background. Hypertrophic olivary degeneration (HOD) is a pathological phenomenon that occurs after injury to the dentato-olivary pathway. Its hallmarks include hypertrophy of the olive with increased T2 signal intensity on magnetic resonance imaging, and it often manifests with palatal tremor and oscillopsia clinically. Method. We report the cases of four patients who developed delayed HOD after surgical resection of pontine lesions. Findings. We discuss the anatomical and pathological details of this disease and review the few other reported cases of HOD after resection of lesions within the brainstem. Conclusions. HOD should be recognized as a possible complication of surgery within the brainstem and must be diagnosed promptly so that patients can be appropriately counseled and symptoms can be treated.
Fatores que contribuem para mortalidade das micro e pequenas empresas no Brasil

Micro and small companies represent 99% of the establishments in operation in Brazil, being an important vector in the economic development of the country. It is commonly thought that small businesses effectively contribute to income generation and employment in the country while living the low-lasting paradox. In this context, this study aimed to analyze the existing literature in search of a common factor that contributes to the early closure of the activities of BrazilianJournal of Development Braz. J. of Develop. , Curitiba, v. 5, n. 7, p. 11107-11122 jul. 2019 ISSN 2525-8761 11108 micro and small companies in the country. The methodology used was the descriptive and qualitative research and as data collection the bibliographic survey. In this context, it was concluded that there are several determining reasons for the closure of activities and mortality of a company, the literature showed that the various factors, together, contribute to the early closure of micro and small companies, being the most cited were: low education and qualification; lack of knowledge of the market in which it operates; lack of strategic planning and difficulties in winning and retaining customers.
Dört ilde çalışan aile sağlığı merkezi personelinin sağlıklı yaşam biçimi davranışları düzeyi, sosyodemografik ve işyeri ile ilgili bazı değişkenlerin buna etkisi

Amac : Bu arastirmanin amaci, Şanliurfa, Canakkale, Mersin ve Manisa illerindeki aile hekimi ve aile sagligi elemanlarinin saglikli yasam bicimi davranislari durumunu belirlemek, bazi sosyodemografik ve isyeri ile ilgili ozelliklerin saglikli yasam bicimi davranislari durumuna etkisini saptamaktir. Y ontem: Arastirma, kesitsel tiptedir. Bu arastirma Şanliurfa, Canakkale, Manisa ve Mersin illerinde uygulanmistir. Iller olasilikli olmayan ornekleme yontemi ile secilmistir. Arastirma populasyonu dort ilde gorev yapmakta olan 1484 aile hekimi ile 1429 aile sagligi elamanidir. Arastirma icin orneklem secilmemis olup tum evrene ulasilmasi hedeflenmistir. Toplamda 917 aile hekimi, 963 aile sagligi elemanina ulasilmis olup arastirmaya katilim %64.5’tir. Calisma verileri yapilandirilmis bir anket ve Saglikli Yasam Bicimi Davranisi Olcegi II ile toplanmistir. Bulgular : Bekar olanlar en fazla Şanliurfa'da (%40.0) en az Manisa'dadir (%4.9). Herhangi bir kronik hastaligi olanlar Şanliurfa'da daha az (%9.7), Mersin'de daha fazladir (%21.9). Kirsal bolgede calisan saglik personeli Şanliurfa'da (%22.4) ve Canakkale'de (%35.7) en fazladir. Gezici saglik hizmeti sunumu en fazla Canakkale (%94.2) ve Şanliurfa'dadir (%56.5). Isinden memnun olmayanlar en fazla Şanliurfa'dadir (%38.8). Saglik personelinde en sik memnuniyetsizlik nedeni is yuku fazlaligidir. Fiziksel aktivite, b eslenme ve stres yonetimi ve toplam SYBD puanlari en dusuk Şanliurfa'daki calisanlardadir. Saglik sorumlulugu, manevi gelisim ve kisilerarasi iliskiler puanlari acisindan iller arasinda farklilik bulunmamaktadir. Sonuc : Secilen iller demografik ozellikler, saglik hizmeti sunumu ve saglik personeli dagilimi acisindan farkli ozelliklere sahiptir. Ozellikle, Şanliurfa'da toplum sagligi hizmetleri gereksinimi cok fazladir fakat saglik calisanlarinin saglikli yasam bicimi davranislari durumu iyi duzeyde degildir. Şanliurfa'da calisanlarin is memnuniyetsizligi en yuksektir. Birinci basamak saglik hizmetlerinde saglik insan gucu planlamasi sadece kisi sayisina gore degil toplumun saglik gereksinimleri de dikkate alinarak yapilmalidir.
Novel therapeutic approaches in management of migraine.

Migraine is neurological disorder greatly affecting the life of many peoples. Current management of migraine deals with Triptans, NSAID drugs. This drugs used in migraine or during attack. These drugs have their own merits and demerits. Preventive measure may not be effective all the times. Emerging drugs like Zonisamide, Levetiracteam, Carvedilol, Quetiapine showing good results. Novel therapeutic like Combination treatment of Sumatriptan-Naproxen, BIBN4096-Dihydroergotamine, Quetiapine-Zolmitriptan and Montelukast, Hydrosoluble Diclofenac epolamine making big impression in migraine treatment. Alternative medicine like Herbal Feverfew and Kudzu root proving effectiveness in therapy. New therapeutic delivery system giving more comfort to migraine patients. Drugs under clinical trial like CGRP antagonist will make difference. And time will come when migraine will no longer remain headache to mankind.
COMPARATIVE PROTEOMICS STUDIES OF SOLUBLE NUCLEAR PROTEINS OF DRUG SUSCEPTIBLE AND RESISTANT HUMAN BREAST CANCER MCF-7 CELLS

Title of Dissertation: COMPARATIVE PROTEOMICS STUDIES OF SOLUBLE NUCLEAR PROTEINS OF DRUG SUSCEPTIBLE AND RESISTANT HUMAN BREAST CANCER MCF-7 CELLS Zongming Fu, Doctor of Philosophy, 2004 Dissertation Directed By: Professor Catherine Fenselau Department of Chemistry and Biochemistry Drug resistance is a major obstacle in cancer chemotherapy. Better understanding of the mechanisms of the drug resistance can help to improve clinical treatment and develop new drugs. Since most anticancer drugs target the nuclei of the cancer cells, differential expression of nuclear proteins may play crucial roles as cancer cells acquire drug resistance. Thus I have carried out a comparative proteomics research project to study differential expression of nuclear proteins in drug resistant human breast cancer MCF-7 cells. Two dimensional gel electrophoresis and stable isotope labeling by amino acids in cell culture are used to conduct the study. Protein identification is acquired by peptide fingerprinting or microsequencing. Relative quantitation of the proteins is derived from gel comparisons and from ratios of labeled and unlabeled peptide pairs. A drug susceptible MCF-7 cell line and four drug resistant MCF-7 cell lines were examined. The drug resistant cell lines are resistant to different chemotherapeutic drugs and are well characterized. The known mechanisms of drug resistance can not satisfactorily answer how the drug resistance
Le cure palliative in Quirinale

Si è trattato di un evento per tutti noi emozionante che ha sintetizzato la storia delle cure palliative e la sua evoluzione nel nostro paese. Proprio nell’editoriale precedente avevo ripercorso le tappe fondamentali delle cure palliative in Italia, descrivendo le difficoltà che ancora sussistono per completare il processo di piena attuazione della Legge 38/2010. Un processo che, pur avendo subito negli ultimi anni un’accelerazione evidente, oggi fatica ancora a garantire ai cittadini di tutte le età, equità d’accesso alle cure palliative e omogeneità di cura. In questa occasione abbiamo potuto coinvolgere direttamente il Capo dello Stato, che si è dimostrato estremamente sensibile e attento, lanciando un appello per compiere un ulteriore passo in avanti verso il completamento dell’applicazione della legge 38.
The Perceptions of K-12 Administrators’ Self-Efficacy on the Usage of Skype as an Online Communication Software Tool

At the study site, K-12 administrators use Skype with a webcam and microphone to communicate with peers. This study sought to answer how Skype, as an online communication tool, contributed to school and district administrators’ reported level of self-efficacy. A sample of n = 39 K-12 administrators was purposefully selected. The major finding was that K-12 administrators reported that Skype is a communication tool that contributes to the increase of their self-efficacy. Administrators’ self-efficacy can be increased through professional development opportunities on online communication tools for ongoing, systemic, and systematic interactions with stakeholders in the school district. Institutes of higher education, professional development providers, K-12 administrators’ associations, and school districts’ personnel may benefit from having an awareness of how online communication software such as Skype can increase administrators’ efficacy in the field of teaching and learning.
NaCl Material for Winter Maintenance and Its Environmental Effect

All over the world, winter maintenance is based on the application of the NaCl salt on roads, a product necessary for the elimination of slippery conditions. The quantities used for the salting operations are increasing with the development of the road network (in France, up to 2 million tons are applied each winter). This chapter will present the salt used as a deicer (its origin and chemical composition) and its chemical properties that are exploited for that purpose. Furthermore, an overview of the means of its transfer from the roads to the environment (soils and waters) as well as its impacts on these media will be presented, a special attention being devoted to the soil. The interactions of salt with other road pollutants and the treatment possibilities in the road pollution context will be discussed.
An investigation into the role of receptor tyrosine kinases in childhood Acute Lymphoblastic Leukaemia

Deregulation of tyrosine kinases has been implicated in Philadelphia chromosome negative Acute Lymphoblastic Leukaemia (ALL) with a higher risk of relapse. The studies in this thesis sought to identify potential receptor tyrosine kinase targets and to explore the use of tyrosine kinase inhibitors (TKIs) in childhood ALL. Initial work describes the baseline receptor tyrosine kinase profiles of 18 primary ALLs. Alterations in the phosphorylation signals of Axl, EphA2, EphB2, FGFR2, FLT3, Mer and PDGFRβ were identified and associated with clinical and biological features. Subsequently, 5 ALL cell lines and a panel of 20 primary samples representative of common biological features were screened for sensitivity to a library of TKIs. Significant heterogeneity in sensitivity was observed in the panel of leukaemia cells. No correlation was evident between response to TKIs and current clinical or biological stratification parameters in the primary cell panel. Two candidate inhibitors, dovitinib and foretinib, were taken forward for further preclinical work. Potent nanomolar activity was demonstrated in cell lines and primary ALL. The combination of dovitinib or foretinib with conventional cytotoxics demonstrated significant synergy and sensitised steroid – resistant cell lines to dexamethasone. Objective responses were not identified to single agent TKI therapy in a murine primagraft model.
A History of Limb Amputation

and Sources. - Natural Causes of Dismemberment. - Accidental Causes for Amputation: Auto-Amputation. - Ritual, Punitive, Legal and Iatrogenic Causes. - Cold Steel and Gunshot Causes. - Elective Amputation: Early Evolution to the End of the 17th Century. - Elective Amputation: From the 18th Century to 1846. - Elective Amputation: From 1846 to Recent Times. - Interpretations of Amputation by Society, Patients and Surgeons. - Surgical Instrumentation and Equipment. - Indications, Timing and Procedures. - Stumps: Reattachment,Management, Complications, Revision and Care for Limb-Fitting. - Artificial Limbs and Rehabilitation.
Gastroenterology : clinical science and practice

Volume 1: Section 1. Mouth, Pharynx and Oesophagus Mouth: Anatomy and Physiology, Oral Disease, Oral Manifestations of Gastrointestinal Disease, Oral Manifestations of Systemic Disease Pharynx and Oesophagus: Embryology and Anatomy, Congenital Abnormalities, Cricopharyngeal Disorders, Physiology, Motility Disorders, Gastro-Oesophageal Reflux Disease, Diaphragmatic Hernias, Indications For, And Outcome Of, Surgery for Benign Oesophageal Disease, Tumours, Other Conditions Section 2. Stomach and Duodenum: Embryology and Anatomy, Congenital Abnormalities, Gastroduodenal Secretion in Health and Disease, Gastroduodenal Motility in Health and Disease, Gastritis, Duodenitis, Chronic Peptic Ulcer, Gastric Tumours, Menetrier's Disease, Other Gastroduodenal Disorders Section 3. The Small Intestine: Anatomy and Congenital Abnormalities, The Gut Response to a Meal and Its Hormonal Control, Digestion and Malabsorption of Nutrients, Intestinal Tranpathophysiology and Pathophysiology), Mechanisms of Malabsorption and Diarrhoea, Clinical Investigations of Patients with Malabsorption and Diarrhoea, The Consequences of Malabsorption, Motility Disorders of the Intestine, Bacteriology of the Small Gut and Bacterial Overgrowth, Postinfective Malabsorption (Including Tropical Sprue), Coeliac Disease and Related Disorders, Whipple's Disease, Immunological Disorders Affecting the Small Intestine, Protein-Losing Enteropathy, Chronic Diseases of the Small Intestine in Childhood, Drug Absorption and Bioavailability, Therapeutic Nutrition, Malnutrition in Developing Countries Section 4. Colon, Rectum and Anus Colon: Embryology and Anatomy, Hirschsprung's Disease, 'Congenital Megacolon', Anorectal Malformation, Constipation, Faecal Impaction and Laxatives, Diverticular Disease, Tumours. Anal and Perirectal Disorders: Phsyiology of Defaecation and Sphincter Control, Pelvic Floor Disorders, Haemorrhoids, Anal Fissure, Anorectal Sepsis, Fistul-In-Ano, Pruritis Ani, Proctalgia Fugax, Malignant Tumours of the Anus, Anal and Perirectal Proble
Estudio comparativo in vitro de la remoción de barrillo dentinario en conductos radiculares entre irrigación ultrasónica y EndoVac

The aims of endodontic therapy are the treatment and prevention of the tooth and thanks to that get the maintenance, repair and recovery of the apical region. Due to anatomical complexity and limitations in instrumentation, irrigation is a fundamental part of the treatment. The use of EndoVac (Discus Dental, Culver City, CA) is currently recommended to remove the smear layer through a mechanism of apical negative pressure. The purpose of this study was to compare in vitro the removal of smear layer at the apical region of the root canal between ultrasonic irrigation and EndoVac. After obtaining the images under the scanning electron microscope, the results show that there is no significant difference between the two groups, however the EndoVac present a slightly larger cleaning than the ultrasound. Until now there is no method that eliminates completely the smear layer in the root canal, so the use of different irrigants and the combination of equipment is needed to increase the cleanliness and thus the success of the endodontic treatment.
A Study of Nurse Practitioner Characteristics and Knowledge of Drug-Drug Interactions

Purpose: Drug-drug interactions (DDIs) place a burden on our nation and cause potential harm to patients. Awareness of potential DDIs is essential for safe prescribing. Nurse practitioners (NP) have prescriptive authority throughout the nation, however, little is known about NP prescribing habits. The purpose of this study was to identify NPs‟ demographic and practice characteristics, DDI knowledge and factors that influence this knowledge. Data Sources: A survey was administered to NP prescribers recruited from a national conference. Data was collected on demographics, practice and technological characteristics, and perceptions and knowledge of DDIs. Conclusions: Data from 305 questionnaires were analyzed. NPs correctly classified 31% of drug pairs. Nitroglycerin and Sildenafil (drug combination to avoid) was classified correctly by the most respondents (90.8%, n = 305); Warfarin and Gemfibrozil (drug combination to usually avoid) the fewest 15.7% (n = 302). A positive correlation was found between NPs in acute care hospital settings and DDI knowledge, indicating higher knowledge scores. Neither hierarchical linear regression model was significant at predicting NPs‟ DDI knowledge. Implications for Practice: Continuing education needs to be targeted to enhance NPs identification and management of potential clinically significant DDIs. Increased recognition of potential DDIs among NPs will enhance patient safety.
The Food and Culture Around the World Handbook

This book provides specific information on the food and culture of each of the 195 countries in the world. Designed to be consistent and concise, it uses an outline format that details the cultural factors related to food ( such as geography, ethnic group, religions and education) and the food itself ( such as typical dishes, special occasion foods, meals and service and street food and snacks). Its goal is to help readers develop multicultural competence and cultural sensitivity so they are more equipped to provide adequate food service, nutrition education, and health care to an increasingly diverse population. Some features for each country entry include:* COUNTRY NAME (Official Name)* Culture* Geography location and topography * Major Languages * Ethnic Groups and % of population in each group * Major Religions Official religion and % of population affiliated with each religion * Agriculture chief crops and livestock* Brief History* Industries * All types of food coverage including influences on food and specialty or occasion food A perfect blend of culture and food, this is a great resource for anyone in the food service industry!
Las smart cities como espacio propicio de acciones ofensivas de ciberdelincuencia

Resumen El Espacio Red se desarrolla a una velocidad vertiginosa, las formas de comunicación de las sociedades de modo tradicional están cambiando por otras que mediante dispositivos digitales están intercomunicadas continuamente, esta sociedad de la información ofrece unas oportunidades de exploración sin límites obteniendo cualquier solicitud de conocimiento en cuestión de segundos sin desplazamiento, creando una mejora en la calidad en la vida diaria gracias a la integración de las nuevas tecnologías. En contrapartida, este mundo digital es el medio propicio para que los ciberdelincuentes puedan tener mayor acceso a sus posibles víctimas abriendo su acción criminal al Espacio Red, siendo capaces de realizar multitud de ciberataques dirigidos a personas, empresas, infraestructuras, ciudades o países creando graves perjuicios económicos en algunos casos o paralización de servicios en otros afectando al normal desarrollo de la sociedad de la información. En este contexto, las plataformas smart city diseñadas en las grandes ciudades para mejorar su eficacia e integración de sus servicios están siendo amenazadas por nuevas formas de delincuencia que a través del ciberespacio pueden llegar a ser vulneradas, poniendo en riesgo la seguridad y la privacidad de sus ciudadanos. En este artículo se describe los problemas de seguridad en las infraestructuras que pueden estar integradas en las plataformas smart city, poniendo en evidencia las posibles brechas de seguridad cuando esos servicios e infraestructuras son vulnerados.
The Impact of Stock Names on the Expected Stock Return

Every investor in the market has access to the stock names, making it the most popular information. However, this piece of information is often ignored by people and considered insignificant in the decision process. In fact, it is almost always the stock names that give investors the first impression of a stock, and thus psychologically speaking, should in turn impact the decision process. In this paper, we score the (Chinese) stock names according to the meaning and the efficiency of passing information, so that we can work out a quantitative analysis of the stock names. Theoretically we derive the relationship between the stock name scores and the expected stock returns. Practically we build up an imaginary market-neutral portfolio and analyze its return by historical data. From both the theoretical and the practical aspects we discuss the two hypotheses—the liking theory and the information theory, and we show that in the Chinese stock market, the liking theory dominates, which is opposite to the result from the US stock market.
Análise de Quantificação de Recorrência do preço do açúcar brasileiro

Os precos de commodities (materias-primas) agricolas nas ultimas decadas subiram exponencialmente, por varios motivos, por exemplo, a desvalorizacao do dolar, ou o desvio de commodities alimentares para a producao de biocombustivel, atingido inumeros paises, principalmente os paises em desenvolvimento, podendo acarretar na inseguranca alimentar, aumentando a fome e a pobreza. Com a crise alimentar nos ultimos anos, surgiu mais interesse em investigar a influencia dos fatores internos e externos do mercado na variacao dos precos de commodities. Neste trabalho, investiga-se a influencia de câmbio no preco do acucar brasileiro utilizando os metodos de grafico de recorrencia cruzado (CRP) e analise de quantificacao de recorrencia cruzada (CRQA) que servem para visualizar e quantificar as trajetorias dos sistemas dinâmicos no mesmo espaco de fase. Os resultados mostram que a dinâmica de correlacao entre as series do preco de acucar em real e dolar tem um comportamento estocastico, com uma baixa sincronizacao e baixo tempo de permanencia em estados similares no espaco de fase.