Miracle-dz/UniFAR-FTUs huggingface dataset:
Contemporary Multi-Institutional Cohort of 550 Cases of Phyllodes Tumors (2007-2017) Demonstrates a Need for More Individualized Margin Guidelines.

PURPOSE Phyllodes tumors (PTs) are rare breast neoplasms, which have little granular data on margins. Current guidelines recommend ≥ 1 cm margins; however, recent data suggest narrower margins are sufficient, and for benign PT, a negative margin may not be necessary. METHODS We performed an 11-institution contemporary (2007-2017) review of PT practices. Demographics, surgical, and histopathologic data were captured. Logistic regression was used to estimate the association of select covariates with local recurrence (LR). RESULTS Of 550 PT patients, the majority underwent excisional biopsy (55.3%, n = 302/546) or lumpectomy (wide excision) (38.5%, n = 210/546). Median tumor size was 30 mm, 68.9% (n = 379) were benign, 19.6% (n = 108) borderline, and 10.5% (n = 58) malignant. Surgical margins were positive in 42% (n = 231) and negative in 57.3% (n = 311). A second operation was performed in 38.0% (n = 209) of the total cohort, including 51 patients with an initial negative margin (82.4% with < 2 mm), and 157 with an initial positive margin, with residual disease only found in six (2.9%). Notably, 32.0% (n = 74) of those with an initial positive margin did not undergo a second operation, among whom only 2.7% (n = 2) recurred. Recurrence occurred in 3.3% (n = 18) of the total cohort (n = 15 LR, n = 3 distant), at median follow-up of 36.7 months. LR (all PT grades) was not reduced with wider negative margin width (≥ 2 mm v < 2 mm: odds ratio [OR] = 0.39; 95% CI, 0.07 to 2.10; P = .27) or final margin status (positive v negative: OR = 0.96; 95% CI, 0.26 to 3.52; P = .96). CONCLUSION In current practice, many patients are managed outside of current guidelines. For the entire cohort, a wider margin width was not associated with a reduced risk of LR. We do not recommend re-excision of a negative margin for benign PT, regardless of margin width, as a progressively wider surgical margin is unlikely to reduce LR.
Evaluation of Naringenin as a Promising Treatment Option for COPD Based on Literature Review and Network Pharmacology

Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by incompletely reversible airflow limitation and seriously threatens the health of humans due to its high morbidity and mortality. Naringenin, as a natural flavanone, has shown various potential pharmacological activities against multiple pathological stages of COPD, but available studies are scattered and unsystematic. Thus, we combined literature review with network pharmacology analysis to evaluate the potential therapeutic effects of naringenin on COPD and predict its underlying mechanisms, expecting to provide a promising tactic for clinical treatment of COPD.
Composition and origin of lung fluid proteome in premature infants and relationship to respiratory outcome

Background Infants born at extremely low gestational age are at high risk for bronchopulmonary dysplasia and continuing lung disease. There are no early clinical biomarkers for pulmonary outcome and limited therapeutic interventions. Objectives We performed global proteomics of premature infant tracheal aspirate (TA) and plasma to determine the composition and source of lung fluid proteins and to identify potential biomarkers of respiratory outcome. Methods TA samples were collected from intubated infants in the TOLSURF cohort before and after nitric oxide treatment, and plasma was collected from NO CLD infants. Protein abundance was assayed by HPLC/tandem mass spectrometry and Protein Prospector software. mRNA abundance in mid-gestation fetal lung was assessed by RNA sequencing. Pulmonary morbidity was defined as a need for ventilatory support at term and during the first year. Results Abundant TA proteins included albumin, hemoglobin, and actin-related proteins. 96 of 137 detected plasma proteins were present in TA (r = 0.69, p<0.00001). Based on lung RNAseq data, ~88% of detected TA proteins in injured infant lung are derived at least in part from lung epithelium with overrepresentation in categories of cell membrane/secretion and stress/inflammation. Comparing 37 infants at study enrollment (7–14 days) who did or did not develop persistent pulmonary morbidity, candidate biomarkers of both lung (eg., annexin A5) and plasma (eg., vitamin D-binding protein) origin were identified. Notably, levels of free hemoglobin were 2.9-fold (p = 0.03) higher in infants with pulmonary morbidity. In time course studies, hemoglobin decreased markedly in most infants after enrollment coincident with initiation of inhaled nitric oxide treatment. Conclusions We conclude that both lung epithelium and plasma contribute to the lung fluid proteome in premature infants with lung injury. Early postnatal elevation of free hemoglobin and heme, which are both pro-oxidants, may contribute to persistent lung disease by depleting nitric oxide and increasing oxidative/nitrative stress.
Rethinking Clinical Trials and Personalized Medicine with Placebogenomics and Placebo Dose.

Pharmacogenomics, nutrigenomics, vaccinomics, and the nascent field of plant omics are examples of variability science. They are embedded within an overarching framework of personalized medicine. Across these public health specialties, the significance and biology of the placebo response have been historically neglected. A placebo is any substance such as a sugar pill administered in the guise of medication, but one that does not have pharmacological activity. Placebos do have clinical effects, however, that can be substantive in magnitude and vary markedly from person-to-person depending, for example, on the type of disease, symptoms, or clinical trial design. Research over the past several decades attests to a genuine neurobiological basis for placebo effects. All drugs have placebo components that contribute to their overall treatment effect. Placebos are used in clinical trials as control groups to ascertain the net pharmacological effect of a drug candidate. Not only less well known but also relevant to rational therapeutics and personalized medicine is the nocebo. A nocebo effect occurs when an inert substance is administered in a context that induces negative expectations, worsening patients' symptoms. With the COVID-19 pandemic, there are high public expectations for new vaccines and medicines to end the contagion, while at the same time antiscience, post-truth, and antivaccine movements are worrisomely on the rise. These social movements, changes in public health cultures, and conditioned behavioral responses can trigger both placebo and nocebo effects. Hence, in clinical trials, forecasting and explaining placebo and nocebo variability are more important than ever for robust science and personalized health care. Against this overarching context, this article provides (1) a brief history of placebo and (2) a discussion on biology, mechanisms, and variability of placebo effects, and (3) discusses three emerging new concepts: placebogenomics, nocebogenomics, and augmented placebo, that is, the notion of a "placebo dose. " We conclude with a roadmap for placebogenomics, its synergies with the nascent field of social pharmacology, and the ways in which a new taxonomy of drug and placebo variability can be anticipated in the next decade.
Interventions to Reduce Opioid Use for Pain Management in the Older Adult Population: A Systematic Review

Question: What interventions are being conducted to reduce opioid use among older adults (age 65+ years)? Design: Systematic review. Method: Five databases were searched for publications from 2005 through 2019. Articles were evaluated by two independent reviewers. The articles were selected related to the search inclusion/exclusion criteria, quality/risk of bias, and ultimately the strength of evidence with a goal of informing clinical practice. Results: In total, 1,105 articles were evaluated. Through abstract and full article review, 1,093 articles were removed. Ultimately, 11 articles were included in the final review, falling into five themes. All themes resulted in low strength of evidence except for the two surgical themes resulted in one recommendation with strong strength of evidence and one recommendation with moderate strength of evidence. Conclusion: There is limited evidence; however, pharmacists should be aware of alternative evidence-based treatments for surgical pain. More research is needed in this area to study issues.
Myocardial Infarction in Systemic Lupus Erythematosus - the Sex Specific Risk Profile.

BACKGROUND Accelerated atherosclerosis is widely present in patients with systemic lupus erythematosus. OBJECTIVE The aim of this review is to analyze the relationship between systemic lupus erythematosus and cardiovascular diseases, with the emphasis on acute myocardial infarction. METHOD We conducted a literature review through PubMed and Cochrane, using key words: SLE, atherosclerosis, atherothrombosis, coronary artery disease, myocardial infarction, prognosis, sex specifics. RESULTS Various molecular mechanisms triggered by infection/inflammation are responsible for endothelial dysfunction and development of atherosclerosis at an earlier age. Contributing factor is the cumulative effect of traditional cardiovascular risk factors interaction with disease related characteristics. Myocardial infarction rates are 2- to 10-fold higher compared to the general population. Young women have the highest relative risk, however, men carry at least 3- fold higher risk than women. Coronary involvement varies from normal coronary artery with thrombosis, coronary microartery vasculitis, coronary arteritis, and coronary atherosclerosis. Typical clinical presentation is observed in men and older women, while atypical is more frequent in young women. Treatment is guided by the underlying mechanism, engaging invasive procedures alone, or accompanied with immunosuppressive and/or antiinflammatory therapy. There are significant gender differences in pathophysiology and clinical presentation. However, they receive the same therapeutic treatments. CONCLUSION Systemic lupus erythematosus is a major contributor to atherosclerotic and non-atherosclerotic mechanisms involved in the development of myocardial infarction, which should be taken into account during therapeutic treatment. Although Systemic lupus erythematosus per se is a "female" disease, males are at increased cardiovascular risk and worse outcome.
Two cases of cryptococcus gattii infection in the rhesus macaque (Macaca Mulatta)

Cryptococcus gattii was diagnosed in two female indoor‐housed rhesus macaques. Gross and histopathologic findings included an isolated pulmonary cryptococcoma in a non‐SIV‐infected macaque and disseminated disease centered on the lungs of an SIV‐infected macaque. Fungal yeast were positive with special stains, and the diagnoses were confirmed with a lateral flow assay and PCR.
Complexity of the Alternative Splicing Landscape in PlantsC

This information is current as of October 31, 2013 Supplemental Data http://www.plantcell. org/content/suppl/2013/10/21/tpc.113. 117523.DC1. html Permissions https://www.copyright. com/ccc/openurl.do? sid=pd_hw1532298X&issn=1532298X&WT. mc_id=pd_hw1532298X eTOCs http://www.plantcell. org/cgi/alerts/ctmain Sign up for eTOCs at: CiteTrack Alerts http://www.plantcell. org/cgi/alerts/ctmain Sign up for CiteTrack Alerts at: Subscription Information http://www.aspb. org/publications/subscriptions.cfm is available at: Plant Physiology and The Plant Cell Subscription Information for
FPT-approximation for FPT Problems

Over the past decade, many results have focused on the design of parameterized approximation algorithms for W[1]-hard problems. However, there are fundamental problems within the class FPT for which the best known algorithms have seen no progress over the course of the decade; some of them have even been proved not to admit algorithms that run in time 2 O ( k ) n O (1) under the Exponential Time Hypothesis (ETH) or ( c − (cid:15) ) k n O (1) under the Strong ETH (SETH). In this paper, we expand the study of FPT-approximation and initiate a systematic study of FPT-approximation for problems that are FPT. We design FPT-approximation algorithms for problems that are FPT, with running times that are signiﬁcantly faster than the corresponding best known FPT-algorithm, and while achieving approximation ratios that are signiﬁcantly better than what is possible in polynomial time. (1
Maternal Mental Health: Where Should Our Research and Policy Priorities Be?

In the midst of the COVID-19 pandemic, mental health care has become an increasingly important topic in light of the cumulative stressors of social isolation, economic insecurity, anxiety and fears of infection, fi nancial hardship, and the potential loss of friends or family. Evidence suggests that mental health disorders, including major depression disorder (MDD) and anxiety disorders, are increasing at an alarming rate in the setting of the COVID-19 pandemic, and access to mental health care remains limited. During this critical time, maternal mental health deserves special attention by researchers and policy makers for several reasons, but particularly because of growing evidence that maternal mental health has long-reaching eff ects on the physical, intellectual, and emotional development of a woman’s children [1]. Maternal mental health is therefore a true public health issue that ultimately affects every one of us. Beyond this compelling reason to focus on maternal mental health, a number of other unique aspects to the mental health of women complicate treatment. For example, women are more likely to be the victims of physical and sexual abuse, and the ebb and fl ow of reproductive hormones can trigger mood and anxiety symptoms in biologically and socioeconomically vulnerable women. Furthermore, treating mental health disorders during the reproductive years requires a specialized knowledge of what medications can be used during pregnancy and lactation and a desperate need for research into best management practices for treatment during this critical time period. The COVID-19 pandemic, by increasing the mental health needs of both women and men, has only served to emphasize the knowledge gaps and need for policy change that will ultimately improve mental health outcomes for not only women, but men as well. On December 2, 2019, the Committee on Population of the National Academies of Sciences, Engineering, and Medicine held a stakeholder meeting on maternal mental health and women’s mental health across the life course. The meeting was meant to build and expand upon a previous workshop—Women’s Mental Health across the Life Course through a Sex and Gender Lens held in March 2018 [11]—with a new focus on maternal mental health. During the meeting, experts and stakeholders discussed maternal mental health and specifi cally focused on the perinatal period. The discussion addressed topics such as risk factors, barriers to mental health care, areas in need of research, and potential policy interventions. The authors of this commentary will present some of these ideas with the added perspective of a reproductive psychiatrist—a psychiatrist who specializes in the mental health care of women during the reproductive years. This commentary will also highlight opportunities brought on by the COVID-19 pandemic that have a bearing on these discussions.
Blood Metabolic Profile in Barki Ewes during Transition Period

: This technical research article investigated the changes in the hemato-biochemical profile in Barki ewes during the transition period. A total of 15 healthy pregnant Barki ewes (age, 4.9 ± 0.7 years old; weight, 38.5 ± 4.9 Kg) were randomly selected for the current study. Blood samples were collected from the selected ewes via jug ular vein puncture during the transition period at five different time points; 4 and 2 weeks prior the estimated date of delivery (EDD), at the parturition time, then at 2 and 4 weeks post-partum. Red blood cells (RBCs) count and packed cell volume (PCV) were significantly (P<0.05) decreased 2 weeks before the EDD and at the parturition time. Mean corpuscular volume (MCV) was significantly (P<0.05) decreased 4 weeks post-partum. The neutrophil count and neu -trophil/lymphocyte ratio were significantly (P < 0.05) increased 2 weeks post-partum. The level of β-hydroxy butyric acid (BHBA) and concentration of non-esterified fatty acid (NEFA) in the serum were significantly (P<0.05) increased 2 weeks before EDD, at the parturition time, and 2 weeks post-partum. Both cholesterol and triglyceride levels in creased significantly (P<0.05) 2 weeks before EDD and at the parturition time. Leptin level was significantly (P<0.05) decreased at 2 weeks and 4 weeks post-partum. Glucose level increased significantly (P<0.05) at the parturition time then decreased significantly (P<0.05) at 2 weeks post-partum, after which it increased again 4 weeks post-partum. Total protein level was significantly (P<0.05) increased 2 weeks post-partum. The level of both calcium and inorganic phosphorus was significantly (P<0.05) decreased at the parturition time and 2 weeks post-partum. The results revealed that Barki ewes showed profound physiological alterations during the transition period which are not necessarily in dicative of a disease, but reflect physiological variations. Therefore, metabolic profile test was needed to determine the nutritional status of Barki ewes, and to take the possible preventive measures that increase ewes’ productivity and predict health disorders.
The Effect of Environmental Regulations on Pollution Concentration: Evidence form Ontario’s Coal Phase out∗

Many countries, including Canada, have started replacing coal with cleaner energy sources for electricity generation. One of the first attempts to achieve this goal in North America was the shut down of coal-fired power plants in Canadian province of Ontario. In this paper, I use data from pollution monitoring networks to estimate the impact of Ontario’s coal phase out on local air quality. I apply a difference-indifferences estimation strategy comparing the pollution concentration within 20 miles of power plants relative to 20-40 miles before and after the shut down. I find that applying this policy decrease O3 and SO2 levels by 6 and 19 percent, respectively. However, the results do not show a statistically significant effect on PM2.5, NOX, NO2, and NO levels. JEL Codes: L94, O51, Q53, Q58, R23 ∗I wish to thank Stefan Staubli, Lucija Muehlenbachs, Mingshan Lu for their great advice and support, and Peter peller for helping me with GIS. †Department of Economics, University of Calgary (email: eadibnia@ucalgary.ca).
A Reference Model for Migrating from CMMI-DEV v1.3 to CMMI v2.0

In today’s high-technology business environment, the success of an organization is highly inﬂuenced by the functionality and quality of the software they use and develop. The challenge is to deliver reliable software on time and on budget. CMMI helps companies improve their software development processes and, although the beneﬁts are clear, the CMMI textual reference models are complicated. With the new version of CMMI, new concepts and relationships were introduced, thus we propose a CMMI v2.0 Reference Model in ArchiMate to facilitate the migration for companies that are already CMMI-DEV v1.3 accredited. To guide our work we used the Design Science Research Methodology and the utility of the model is demonstrated in a real-world organization that is CMMI-DEV v1.3 accredited and needs to migrate to CMMI v2.0. The demonstration is based on CMMI models in ArchiMate, together with models of the AS-IS and TO-BE enterprise architecture of the organization. To validate the proposed reference model and the demonstration, we used questionnaires and interviews to CMMI experts and practitioners, well as well-known techniques to evaluate Design Science artifacts.
Serum Albumin Level in Second and Third Trimester Pregnancies in Makurdi, Nigeria

DOI: 10.21276/sjbr.2018. 3.6. 2 Abstract: Certain physiological changes occur during normal pregnancy. These changes when exaggerated could result to adverse maternal outcome. Adverse cardiovascular outcomes have been previously linked with hypoalbuminemia in the general population. Few reports exist about serum albumin level in second and third trimester of pregnancy. Our study aims at determining serum albumin level in second and third trimesters of pregnancy. This was a case-control study involving randomly selected 40 non pregnant and 77 pregnant women in Makurdi, Nigeria. The participants were subdivided into 3 comparable groups; control n=40, second trimester n=37 and third trimester n=40. Mean age, body mass index (BMI), and serum albumin in the study groups were compared using ANOVA. Associations of age, BMI, gestation age and albumin were determined using Pearson correlation analysis. Serum albumin level was significantly (P<0.0004) lower in the pregnant groups compared to the controls. A post hoc test reveals a significant (P<0.0001) lower serum albumin in third trimester group than in second trimester and controls. Conclusion: Knowledge about hypoalbuminemia during pregnancy will help distinguish pathological hypoalbuminemia during antenatal checkup.
Preemptive Online Machine Minimization

In this paper, we will survey recent progress on the preemptive online machine minimization problem. The goal of this machine minimization problem is to determine a feasible schedule for preemptive jobs on a minimum number of parallel machines for jobs with hard deadlines. In the online version of the problem, a job is not visible until its release date, and “preemptive” means a job can be stopped and reassigned to any machine later without losing the processing it has already received. We introduce two basic greedy algorithms, which do not do well on this problem, and analyze two recent algorithms both proposed by Chen et al. [4, 2], which achieve good competitive ratios
NAUIR at the NTCIR-15 WWW-3 Task

The NAUIR team participate in English subtasks of the NTCIR-15 We Want Web-3 (WWW-3) task. This paper describes our methods and results in the English subtask of WWW-3. For the English subtask in this task, we use the modified DRMM model and the BERT model for query and document matching. In the pre-training, we only use the documents of the WWW-3 task for word embedding training. The BERT model uses the bert-base-uncased pre-training model officially provided by Google. The experiment shows that the results of our modified DRMM model and the BERT model are better than those of BASELINE
Corporate Governance and Corporate performance: Lessons from Pre and Post Adoption of International Financial Reporting Standards in Nigeria

Article History Received: 28.04. 2018 Accepted: 15.05. 2018 Published: 30.05. 2018 Abstract: Corporate governance is mechanism use to improve firm performance and value because it reduces the level of expropriation of the company’s assets by the management and it also improves the level of expected cash flows that can be distributed to shareholders in form of dividends. The study examines how corporate governance has affected corporate performance under pre and post adoption of IFRS. The findings show that corporate governance is more effective in explaining and predicting corporate performance of listed deposit money banks in Nigeria after the adoption of IFRS better than before the adoption. In view of this, the study recommends that there is need to encourage application of IFRS principles by banks and other institutions to enhance corporate performance of deposit money banks in Nigeria.