Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of a Pharmacist-Managed Heart Failure Education Project

Background: Recent reimbursement cuts for hospitals with higher 30-day heart failure (HF)-related readmission rates call for means of reducing those readmissions. Objective: To determine if pharmacist-initiated education increases HF knowledge and assess if an increase in HF knowledge decreases HF readmission. Methods: This was a prospective interventional study. Participants were ≥18 years old admitted through the emergency department of a 322-bed community hospital with a diagnosis and/or past medical history of HF. Terminal/palliative care patients, patients residing in an assisted-living environment, or patients with a mental illness that deemed them incapable of participating were excluded. Forty-eight patients received pharmacist-initiated HF education on HF pathophysiology and its pharmacologic and nonpharmacologic treatment. Medication assistance and ancillary services were consulted when necessary. Patients’ knowledge of HF was assessed using the same questionnaire prior to education and through a follow-up phone call within 7 days postdischarge. Results: Posteducation HF knowledge scores were 13.7 points higher than preeducation scores (P < .05). Twenty-five patients (52%) had HF as a primary discharge diagnosis. Of those patients, 9 (36%) were readmitted within 30 days for any cause. Only 3 patients (12%) had a HF-related diagnosis at readmission. There was a statistical difference in the level of knowledge but that was not translated into a statistical difference in readmission rates. Conclusion: Patients’ HF knowledge scores increased after pharmacist education. Improvements in HF knowledge could not be correlated with readmission rates. However, the majority of HF patients in this study did not have a HF-related diagnosis at the time of readmission.
Tuning resistive switching on single-pulse doped multilayer memristors

Short-period multilayers containing ultrathin atomic layers of Al embedded in titanium dioxide (TiO2) film—here called single-pulse doped multilayers—are fabricated by atomic layer deposition (ALD) growth methods. The approach explored here is to use Al atoms through single-pulsed deposition to locally modify the chemical environment of TiO2 films, establishing a chemical control over the resistive switching properties of metal/oxide/metal devices. We show that this simple methodology can be employed to produce well-defined and controlled electrical characteristics on oxide thin films without compound segregation. The increase in volume of the embedded Al2O3 plays a crucial role in tuning the conductance of devices, as well as the switching bias. The stacking of these oxide compounds and their use in electrical devices is investigated with respect to possible crystalline phases and local compound formation via chemical recombination. It is shown that our method can be used to produce compounds that cannot be synthesized a priori by direct ALD growth procedures but are of interest due to specific properties such as thermal or chemical stability, electrical resistivity or electric field polarization possibilities. The monolayer doping discussed here impacts considerably on the broadening of the spectrum of performance and technological applications of ALD-based memristors, allowing for additional degrees of freedom in the engineering of oxide devices.
Probing the photothermally induced phase transitions in single-crystalline vanadium dioxide nanobeams

Using Raman spectroscopy, we demonstrated photothermally induced crystallographic phase transitions of vanadium dioxide (VO2) nanobeams clamped to and free-standing on a substrate. Compared to the temperature-dependent Raman measurements, the laser-power-dependent Raman characteristics provide substantial evidence for the photothermal origin of the phase transitions of the VO2 nanobeams. The laser power necessary to cause phase transitions in the free-standing nanobeam was approximately eight times smaller than the laser power used in the substrate-clamped nanobeam. Our study will enhance the understanding of the complex phase transitions of strongly correlated oxides and thereby provide a foundation for engineering desirable properties in novel devices.
Analytic differential approach for robust registration of rat brain histological images

Image registration is an important topic in medical image analysis. It is usually used to reconstruct 3D structure of tissues from a series of microscopic images. However, a variety of inherent factors may result in great differences between acquired slices during imaging even if they are adjacent. The common differences include the color difference and geometry discrepancy, which make the registration problem a difficult challenge. In this study, we propose a robust registration method to automatically reconstruct 3D volume data of the rat brain. It mainly consists of three procedures, including multiscale wavelet‐based feature extraction, analytic robust point matching (ARPM), and registration refinement with feature‐based modified Levenberg‐Marquardt algorithm (FMLM). The product of gradient moduli in multi‐scales is used to decide if extracted feature points are true according to the characteristic that features could exist in multiscale. The ARPM registration algorithm is proposed to speedily accomplish the registration of two point sets with different size by simultaneously evaluating the spatial correspondence and geometrical transformation. In addition, a FMLM method is also proposed to further refine registration results and achieve subpixel accuracy. The FMLM method converges much faster than most other methods due to its feature‐based and nonlinear characteristic. The performance of proposed method is evaluated by comparing it with well‐known thin‐plate spline robust point matching (TPS‐RPM) algorithm. The results indicate that ARPM‐FMLM algorithm is a robust and fast method in image registration. Microsc. Res. Tech., 2010. © 2010 Wiley‐Liss, Inc.
The Use of Cognitive Aids During Simulated Pediatric Cardiopulmonary Arrests

Background: Management of pediatric cardiopulmonary arrest (CPA) is challenging because of the low volume of experience of most pediatric health care providers. Use of cognitive aids may assist in making rapid decisions in these crises; however, there are no known published reports on whether these aids are actually used during arrest management and whether they impact quality of care. Methods: Sixty pediatric residents participated in individual simulated CPA scenarios, which involved pulseless ventricular tachycardia and pulseless electrical activity. Our primary outcome measure was the proportion of pediatric residents who used cognitive aids during simulated CPAs. Secondary outcome measures were to quantify 1) type of aids used, 2) category of use, and 3) human errors made during resuscitation efforts. Results: Eighty-five percent of residents voluntarily used a cognitive aid to assist in managing simulated pediatric CPAs. The most commonly used aids were an American Heart Association Pediatric Advanced Life Support aid and an institutionally created aid. Forty-three of 51 (84.3%) and 23 of 46 (60.5%) residents used these aids for assistance with the pulseless ventricular tachycardia and pulseless electrical activity algorithm, respectively. Unfortunately, 13 of 51 (25.5%) residents chose the incorrect treatment algorithm, resulting in inappropriate management. Conclusion and Application: Although the majority of residents chose to use cognitive aids for assistance, errors in management were common. Further study is required to determine whether these errors are associated with cognitive aid design flaws and whether improving their design through human factors research can help minimize errors in Basic and Advanced Life Support, ultimately improving patient outcomes.
Add a third dimension to your patient care with cone beam computed tomography

Cone-beam computed tomography (CBCT) has been specifically designed to produce undistorted three-dimensional information of the maxillofacial skeleton, including the teeth and their surrounding tissues with a significantly lower effective radiation dose compared with conventional computed tomography. The revolutionary introduction of CBCT in all fields of dentistry is unprecedented as it has created a true paradigm shift from a conventional two-dimensional approach to a three-dimensional understanding. In doing so it has expanded the role of imaging from its traditional one in diagnosis to image guidance of operative and surgical procedures. Clinical Relevance To Interdisciplinary Dentistry Detecting anatomical variants such as accessory neurovascular canals, bony undercuts, and local alterations in trabecular patterns, all of which influence implant treatment planning Identification of root canal system anomalies and determination of root curvature for successful endodontic practice Cone beam computed tomography, offers an opportunity to see inside the bone and pinpoint and measure densities in small localized areas such as a vertical periodontal defect or alveolar bone graft Three-dimensional and cross-sectional evaluation of the implant patient and it allows virtual implant placement that can guide the implantologist in terms of density and thickness of the alveolar bone.
CHANGES WITH AGE IN THE CORNEAL ENDOTHELIUM OF NOMAL RABBITS *

In the course of studies of the interaction between certain animal viruses and corneal endothelium of rabbits, a technique was developed to separate a sheet of cells comprising the entire corneal endothelium from the underlying Descemet’s membrane (Oh & Evans 1960 and Oh 1962). This method made possible the morphological study of cells in the entire layer of corneal endothelium. In the present study, determinations were made on the total number of cells and the number and distribution of mitotic figures in the corneal endothelium of normal rabbits of various ages.
Response Letter to Lakin and Doe

To the Editor: Sakamoto and colleagues generated a welldesigned, multisite, longitudinal randomized controlled trial to evaluate whether a lavender aromatherapy patch would reduce falls in elderly nursing home residents. The authors did an impeccable job of detailing important outcomes and variables such as functional ability, cognitive function, and behavioral and psychological concerns that could have revealed a failure of randomization. They also set out, using careful longitudinal monitoring of such variables, an interesting set of secondary outcomes, some of which showed significant benefit of lavender patches. Nevertheless, we are concerned about the selective presentation of results in the abstract and in the discussion that give readers a false impression of the primary outcome of the trial. In the abstract, the authors state that the results showed fewer fallers in the lavender group than in the placebo group. The authors failed to report at that point that there was no statistically significant difference in the main outcome of number of falls (P = .08), a critical point for interpreting the trial correctly. Furthermore, they failed to report the unadjusted hazard ratio for their primary outcome (0.67, 95% confidence interval = 0.40–1.10; P = .11). In the abstract, the authors report a significant hazard ratio yielded by an adjusted model (Model 2) without stating that they did so. Statistical significance was demonstrated only after adjustments for variables that appeared equal at baseline and theoretically controlled for by randomization (age, sex, fall history, Mini-Mental State Examination score, Cohen-Mansfield Agitation Inventory score, transfer status, visual status, and tranquilizer use). Although there are instances in which adjustment can be considered, the authors failed to describe in the Methods section why they adjusted for confounders. What was the reasoning for these adjustments? Was this analysis preplanned or completed after data collection? Table 1 did not show any significant differences in many of these particular variables; why then did the authors choose them for their models? Why did they feel that this information was appropriate to leave out of the abstract and instead be replaced by an adjusted model without describing the reasons for doing so? These adjustments and lack of clear and consistent labeling seem to cast a shadow on what was otherwise a well-designed and important trial assessing the effect of this low-risk, promising intervention.
Tuning indium tin oxide work function with solution-processed alkali carbonate interfacial layers for high-efficiency inverted organic photovoltaic cells

Selective electron collection by an interfacial layer modified indium tin oxide cathode is critically important for achieving high-efficiency inverted structure organic photovoltaic (OPV) cells. Here, we demonstrate that solution-processed alkali carbonates, such as Li2CO3, Na2CO3, K2CO3, Rb2CO3, Cs2CO3, are good interfacial layer materials. Both carbonate concentration and annealing conditions can affect cathode work function and surface roughness. By proper optimization, different alkali carbonates can be almost equally effective as the cathode interfacial layer. Furthermore, good device performance can be achieved at a low annealing temperature (<50 ° C), which allows for potential applications in solution-processed inverted OPV cells on plastic substrates. This work indicates that alkali carbonates, not just cesium carbonate, are valid choices as the cathode interlayer in inverted OPV devices.
Validation of Global Rating Scale and Checklist Instruments for the Infant Lumbar Puncture Procedure

Introduction The Patient Outcomes in Simulation Education network has developed tools for the assessment of competency to perform the infant lumbar puncture (ILP) procedure. The objective of this study was to evaluate the validity and reliability of these tools in a simulated setting. Methods We developed a 4-point anchored global rating scale (GRS) and 15-item dichotomous checklist instrument to assess ILP performance in a simulated environment. Video recordings of 60 subjects performing an unsupervised lumbar puncture on an infant bench top simulator were collected prospectively; 20 performed by subjects in each of 3 categories (beginner, intermediate experienced, or expert). Three blinded, expert raters independently scored each subject’s video recording using the GRS and checklist instruments. Results The final version of the scoring instruments is presented. Across all subject groups, higher GRS scores were found with advancing level of experience (P < 0.01). Total checklist scores were similar between the expert and intermediate experienced groups (P = 0.54). Both groups scored higher than the beginner group on the checklist instrument (P < 0.01). For each rater, a significant positive correlation was found between GRS scores and total checklist scores (median &rgr; = 0.75, P < 0.01). Cronbach &agr; coefficient for the checklist was 0.77. The intraclass correlation coefficients between raters for the GRS and total checklist scores were 0.71 and 0.52, respectively. Conclusions This study provides some initial evidence to support the validity and reliability of the ILP-anchored GRS. Acceptable internal consistency was found for the checklist instrument. The GRS instrument outperformed the checklist in its discriminant ability and interrater agreement.
Hypertension in the very elderly

The world population is aging and disorders that are more prevalent in the elderly are of increasing importance. Hypertension falls into this category and has been linked to many adverse outcomes from stroke to mortality and dementia. Antihypertensive treatment has been shown to be successful in younger age groups but in those aged 80 years and over its benefits are not yet proven, and the risks and benefits of hypertension and antihypertensive treatment are unclear. Given this, it is useful to examine hypertension in the very elderly, the epidemiology, the likely impact of hypertension in this population, both physical and mental, and the as yet unclear issue of treatment. An ongoing, randomized, controlled trial in this age group will aid resolution of these issues and our understanding of this very elderly group.
Inorganic composition and filler particles morphology of conventional and self‐adhesive resin cements by SEM/EDX

The purpose of this study was to characterize the inorganic components and morphology of filler particles of conventional and self‐adhesive, dual‐curing, resin luting cements. The main components were identified by energy dispersive X‐ray spectroscopy microanalysis (EDX), and filler particles were morphologically analyzed by scanning electron microscopy (SEM). Four resin cements were used in this study: two conventional resin cements (RelyX ARC/3M ESPE and Clearfil Esthetic Cement/Kuraray Medical) and two self‐adhesive resin cements (RelyX Unicem/3M ESPE and Clearfil SA Luting/Kuraray Medical). The materials (n = 5) were manipulated according to manufacturers' instructions, immersed in organic solvents to eliminate the organic phase and observed under SEM/EDX. Although EDX measurements showed high amount of silicon for all cements, differences in elemental composition of materials tested were identified. RelyX ARC showed spherical and irregular particles, whereas other cements presented only irregular filler shape. In general, self‐adhesive cements contained higher filler size than conventional resin luting cements. The differences in inorganic components and filler particles were observed between categories of luting material and among them. All resin cements contain silicon, however, other components varied among them. Microsc. Res. Tech. 2012. © 2012 Wiley Periodicals, Inc.
Thromboprophylaxis After Hip Fractures

Summary: Hip fractures are becoming increasingly common in the United States as the elderly population grows. In addition to cardiopulmonary and other medical complications, hip fracture patients are at extremely high risk for the development of venous thromboembolism (VTE). Although well-designed clinical studies analyzing the efficacy and safety of a variety of therapeutic modalities has been performed, an ideal prophylactic agent for VTE after hip fracture surgery has yet to be identified. Given the fragility of most patients with hip fractures, the choice of prophylaxis must be made carefully to balance the efficacy of the agent against the risks of postoperative bleeding. The purpose of this review is to summarize the literature regarding diagnosis and treatment of VTE after hip fractures.
Sucrose ester stabilized solid lipid nanoparticles and nanostructured lipid carriers: II. Evaluation of the imidazole antifungal drug-loaded nanoparticle dispersions and their gel formulations

This study focused on: (i) feasibility of the previously developed sucrose ester stabilized SLNs and NLCs to encapsulate different imidazole antifungal drugs and (ii) preparation and evaluation of topical gel formulations of those SLNs and NLCs. Three imidazole antifungal drugs; clotrimazole, ketoconazole and climbazole were selected for this study. The results suggested that size, size distribution and drug encapsulation efficiency depend on the drug molecule and type of nanoparticles (SLN/NLC). The drug release experiment always showed faster drug release from NLCs than SLNs when the same drug molecule was loaded in both nanoparticles. However, drug release rate from both SLNs and NLCs followed the order of climbazole > ketoconazole > clotrimazole. NLCs demonstrated better physicochemical stability than SLNs in the case of all drugs. The drug release rate from ketoconazole- and clotrimazole-loaded SLNs became faster after three months than a fresh formulation. There was no significant change in drug release rate from climbazole-loaded SLNs and all drug-loaded NLCs. Gel formulations of SLNs and NLCs were prepared using polycarbophil polymer. Continuous flow measurements demonstrated non-Newtonian flow with shear-thinning behavior and thixotropy. Oscillation measurements depicted viscoelasticity of the gel formulations. Similar to nanoparticle dispersion, drug release rate from SLN- and NLC-gel was in the order of climbazole > ketoconazole > clotrimazole. However, significantly slower drug release was noticed from all gel formulations than their nanoparticle counterparts. Unlike nanoparticle dispersions, no significant difference in drug release from gel formulations containing SLNs and NLCs was observed for each drug. This study concludes that gel formulation of imidazole drug-loaded SLNs and NLCs can be used for sustained/prolonged topical delivery of the drugs.
The first year operating experience of the Florida Dementia Registry

In January of 1987, Suncoast Gerontology Center at the University of South Florida in Tampa, signed a contract with the Department of Health and Rehabilitative Services (HRS) to establish and develop a statewide Registry for patients with Alzheimer's disease and other memory disorders. The realization of the Registry's goals depends on the support and cooperation of all the participating programs. Suncoast Gerontology Center has the responsibility to demonstrate the utility of the data collection by stimulating new research and by enhancing communication and collaboration with service and research institutions throughout Florida. Preliminary results will be presented in this article regarding the sociodemographic characteristics of Registry patients. Also, an attempt will be made to identify risk factors associated with Alzheimer's disease for this group.
Work-Related Musculoskeletal Disorders in Sonographers

The historical perspective of the problem ofwork-related musculoskeletal disorders (WRMSD)is outlined to understand why a newbiopsychosocial paradigm is required. The availableepidemiologic evidence is reviewed, and theclinical problem underlying the chronic pain thatmany sonographers experience is identified. Problem solving is broken down into identifyingobstacles to recovery. Causation is multifactorial, and therefore management must bemultimodal. A case that had a good outcome ispresented. New industry standards (May 2003)for the prevention of WRULD in sonographersare cited.
THE TREATMENT OF CONGENITAL DACRYOCYSTITIS

The term "congenital dacryocystitis" is a misnomer. The condition develops after birth, and not before, and is not a true inflammation of the sac wall, but an infection of the retained excretions from the conjunctival sac. The condition that predisposes to this postnatal infection, however, is congenital in the sense that there has been a delay in Nature's process of canalization of the lacrimal passageways. This is manifest in at least 95 per cent. of all cases by delayed opening into the inferior nasal wall. We are indebted to Born, Legal, Kolliker, Ewetzky, Schaeffer and others for our knowledge concerning the embryologic development of the nasolacrimal passageways; but to Schaeffer, perhaps, belongs the credit of a more thorough study of the subject in the human embryo, commencing when the initial cells are laid down and continuing the study until it is complete at the end of gestation. From his investigations,