Miracle-dz/UniFAR-FTUs huggingface dataset:
Diffusion barrier properties of tungsten nitride films grown by atomic layer deposition from bis(tert-butylimido)bis(dimethylamido)tungsten and ammonia

Highly uniform, smooth, and conformal coatings of tungsten nitride (WN) were synthesized by atomic layer deposition (ALD) from vapors of bis(tert-butylimido)bis(dimethylamido)tungsten and ammonia. The films are shiny, silver colored, and electrically conducting. The films were amorphous as deposited. 100% step coverage was obtained inside holes with aspect ratios greater than 40:1. WN films as thin as 1.5 nm proved to be good barriers to diffusion of copper for temperatures up to 600 °C. Annealing for 30 min at temperatures above 725 °C converted the WN to pure, polycrystalline tungsten metal. ALD of copper onto the surface of the WN produced strongly adherent copper films that could be used as “seed” layers for chemical vapor deposition or electrodeposition of thicker copper coatings.
In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19

The COVID-19 pandemic has already taken the lives of more than 2 million people worldwide, causing several political and socio-economic disturbances in our daily life. At the time of publication, there are non-effective pharmacological treatments, and vaccine distribution represents an important challenge for all countries. In this sense, research for novel molecules becomes essential to develop treatments against the SARS-CoV-2 virus. In this context, Mexican natural products have proven to be quite useful for drug development; therefore, in the present study, we perform an in silico screening of 100 compounds isolated from the most commonly used Mexican plants, against the SARS-CoV-2 virus. As results, we identify ten compounds that meet leadlikeness criteria (emodin anthrone, kaempferol, quercetin, aesculin, cichoriin, luteolin, matricin, riolozatrione, monocaffeoyl tartaric acid, aucubin). According to the docking analysis, only three compounds target the key proteins of SARS-CoV-2 (quercetin, riolozatrione and cichoriin), but only one appears to be safe (cichoriin). ADME (absorption, distribution, metabolism and excretion) properties and the physiologically based pharmacokinetic (PBPK) model show that cichoriin reaches higher lung levels (100 mg/Kg, IV); therefore, it may be considered in developing therapeutic tools.
Domestic abuse among female doctors: thematic analysis of qualitative interviews in the UK

Background Doctors can be victim-survivors of domestic abuse (DA), but how this impacts their work and wellbeing, and whether they face barriers to seeking help is not well understood. Aim To understand single doctor mothers’ lived experience of DA, barriers to seeking help, and impact on their work. Design and setting Individual qualitative interviews with female doctors in the UK who had left an abusive relationship. Interviews were conducted between August 2019 and March 2020. Method Participants were invited via a closed online forum for female doctors who are single parents. In total, 114 females expressed interest. In-depth semi-structured telephone interviews were audiorecorded and transcribed. Transcripts were uploaded to NVivo and analysed using inductive thematic analysis. Results A total of 21 participants were interviewed. The internalised stigma of DA affected participants’ sense of identity and belonging as a doctor, causing social and professional isolation. Many participants felt that the acute stress of DA had an impact on their work, yet often felt unable to take time off. Barriers to seeking help included lack of confidentiality, especially where the abusive partner was also a doctor (sometimes accusing the victim-survivor of mental illness or threatening to report them to the General Medical Council). Participants found peer support helpful, as well as consulting health professionals who were empathic towards them. After they had left the abusive relationship victim-survivors felt better equipped to support patients going through DA. Conclusion Domestic abuse impacts on the work and wellbeing of female doctors, who face unique barriers to help seeking and reporting DA. An online peer support group can help to break the sense of isolation, but specialised confidential support services are also required to help doctors experiencing DA.
Olive Fruit and Leaf Wastes as Bioactive Ingredients for Cosmetics—A Preliminary Study

Olea europaea cultivar, native in the Mediterranean basin, has expanded worldwide, mainly due to the olive oil industry. This expansion is attributed to the benefits of olive oil consumption, since this product is rich in nutritional and bioactive compounds. However, the olive industry generates high amounts of wastes, which could be related to polluting effects on soil and water. To minimize the environmental impact, different strategies of revalorization have been proposed. In this sense, the aim of this work was to develop high cosmetic value added oleuropein-enriched extracts (O20 and O30), a bioactive compound from olive byproducts, performing a comprehensive characterization using high performance liquid chromatography coupled to mass spectrometry and evaluate their bioactivity by in vitro assays. A total of 49 compounds were detected, with oleuropein and its derivatives widely found in O30 extract, whereas iridoids were mainly detected in O20 extract. Moreover, 10 compounds were detected for the first time in olive leaves. Both extracts demonstrated strong antioxidant and antiradical activities, although O30 showed higher values. In addition, radical oxygen and nitrogen species scavenging and enzyme inhibition values were higher in O30, with the exception of HOCl and hyaluronidase inhibition assays. Regarding cell viability, olive byproduct extracts did not lead to a decrease in keratinocytes viability until 100 µg/mL. All data reported by the present study reflect the potential of industrial byproducts as cosmetic ingredients.
SNP in Potentially Defunct Tetrahydrocannabinolic Acid Synthase Is a Marker for Cannabigerolic Acid Dominance in Cannabis sativa L.

The regulation of cannabinoid synthesis in Cannabis sativa is of increasing research interest as restrictions around the globe loosen to allow the plant’s legal cultivation. Of the major cannabinoids, the regulation of cannabigerolic acid (CBGA) production is the least understood. The purpose of this study was to elucidate the inheritance of CBGA dominance in C. sativa and describe a marker related to this chemotype. We produced two crossing populations, one between a CBGA dominant cultivar and a tetrahydrocannabinolic acid (THCA) dominant cultivar, and one between a CBGA dominant cultivar and a cannabidiolic acid (CBDA) cultivar. Chemical and genotyping analyses confirmed that CBGA dominance is inherited as a single recessive gene, potentially governed by a non-functioning allelic variant of the THCA synthase. The “null” THCAS synthase contains a single nucleotide polymorphism (SNP) that may render the synthase unable to convert CBGA to THCA leading to the accumulation of CBGA. This SNP can be reliably used as a molecular marker for CBGA dominance in the selection and breeding of C. sativa.
Synergy-Based Sensor Reduction for Recording the Whole Hand Kinematics

Simultaneous measurement of the kinematics of all hand segments is cumbersome due to sensor placement constraints, occlusions, and environmental disturbances. The aim of this study is to reduce the number of sensors required by using kinematic synergies, which are considered the basic building blocks underlying hand motions. Synergies were identified from the public KIN-MUS UJI database (22 subjects, 26 representative daily activities). Ten synergies per subject were extracted as the principal components explaining at least 95% of the total variance of the angles recorded across all tasks. The 220 resulting synergies were clustered, and candidate angles for estimating the remaining angles were obtained from these groups. Different combinations of candidates were tested and the one providing the lowest error was selected, its goodness being evaluated against kinematic data from another dataset (KINE-ADL BE-UJI). Consequently, the original 16 joint angles were reduced to eight: carpometacarpal flexion and abduction of thumb, metacarpophalangeal and interphalangeal flexion of thumb, proximal interphalangeal flexion of index and ring fingers, metacarpophalangeal flexion of ring finger, and palmar arch. Average estimation errors across joints were below 10% of the range of motion of each joint angle for all the activities. Across activities, errors ranged between 3.1% and 16.8%.
Multi-View Gait Image Generation for Cross-View Gait Recognition

Gait recognition aims to recognize persons’ identities by walking styles. Gait recognition has unique advantages due to its characteristics of non-contact and long-distance compared with face and fingerprint recognition. Cross-view gait recognition is a challenge task because view variance may produce large impact on gait silhouettes. The development of deep learning has promoted cross-view gait recognition performances to a higher level. However, performances of existing deep learning-based cross-view gait recognition methods are limited by lack of gait samples under different views. In this paper, we take a Multi-view Gait Generative Adversarial Network (MvGGAN) to generate fake gait samples to extend existing gait datasets, which provides adequate gait samples for deep learning-based cross-view gait recognition methods. The proposed MvGGAN method trains a single generator for all view pairs involved in single or multiple datasets. Moreover, we perform domain alignment based on projected maximum mean discrepancy to reduce the influence of distribution divergence caused by sample generation. The experimental results on CASIA-B and OUMVLP dataset demonstrate that fake gait samples generated by the proposed MvGGAN method can improve performances of existing state-of-the-art cross-view gait recognition methods obviously on both single-dataset and cross-dataset evaluation settings.
Nuclear Mechanotransduction in Skeletal Muscle

Skeletal muscle is composed of multinucleated, mature muscle cells (myofibers) responsible for contraction, and a resident pool of mononucleated muscle cell precursors (MCPs), that are maintained in a quiescent state in homeostatic conditions. Skeletal muscle is remarkable in its ability to adapt to mechanical constraints, a property referred as muscle plasticity and mediated by both MCPs and myofibers. An emerging body of literature supports the notion that muscle plasticity is critically dependent upon nuclear mechanotransduction, which is transduction of exterior physical forces into the nucleus to generate a biological response. Mechanical loading induces nuclear deformation, changes in the nuclear lamina organization, chromatin condensation state, and cell signaling, which ultimately impacts myogenic cell fate decisions. This review summarizes contemporary insights into the mechanisms underlying nuclear force transmission in MCPs and myofibers. We discuss how the cytoskeleton and nuclear reorganizations during myogenic differentiation may affect force transmission and nuclear mechanotransduction. We also discuss how to apply these findings in the context of muscular disorders. Finally, we highlight current gaps in knowledge and opportunities for further research in the field.
Comparison of Vasopressin versus Norepinephrine in a Pig Model of Refractory Cardiogenic Shock Complicated by Cardiac Arrest and Resuscitated with Veno-arterial ECMO

Supplemental Digital Content is available in the text ABSTRACT Background: The choice of the best vasopressor after ExtraCorporeal Membrane Oxygenation (ECMO) implantation after cardiac arrest is not well defined. Circulatory flow recovery with ECMO is associated with vasoplegia and vasopressor need. The present study aimed to compare the effects of norepinephrine and vasopressin in the first 6 h after ECMO initiation. Methods: Cardiac arrest was induced in 20 pigs by coronary surgical ligature and veno-arterial-ECMO was started after a 30-min period of cardio-pulmonary resuscitation. Pigs were randomized into two groups, arginine vasopressin (AVP) or norepinephrine (NE), with the drugs titrated to maintain a mean arterial pressure (MAP) at 65 mm Hg. Macrocirculatory and metabolic parameters were assessed by lactate clearance. Microcirculatory parameters were assessed by sublingual microcirculation with Sidestream Dark Field imaging and peripheral Near InfraRed Spectroscopy. Pulmonary edema was evaluated by measuring lung wet/dry weight ratio. Results: No difference was found between groups regarding ECMO flow and MAP. Fluid resuscitation volume was higher in the NE group (14,000 [11,250–15,250] mL vs. 3,500 [1,750–4,000] mL in the AVP group, P < 0.05). Lung wet/dry weight ratio was higher in the Norepinephrine group. Lactate clearance between H0 and H6 was higher in the AVP group (47.84 [13.42–82.73]% vs. the NE group 25.66 [−7.31 to 35.34)% vs. P < 0.05). No significant difference was observed for sublingual microcirculation values. Baseline tissue oxygen saturation was comparable and higher at both H3 and H6 in the Vasopressin group comparatively to the Norepinephrine group (P < 0.05). Renal and liver function evolution also remained similar in the two groups throughout the study. Conclusions: AVP administration in refractory cardiac arrest resuscitated by veno-arterial-ECMO is associated with a faster lactate clearance, less fluid resuscitation, and less pulmonary edema when compared with NE for similar global and regional hemodynamic effects.
Development of a QuEChERS-LCMS/MS method for simultaneous estimation of tebuconazole and chlormequat chloride in wheat crop

Abstract Tebuconazole (TBZ) and Chlormequat chloride (CCC) combination has been established as highly effective in reducing plant height of lodging prone wheat varieties. In this work, a novel analytical method employing the quick, easy, cheap, effective, rugged and safe (QuEChERS) cleanup technique and LC-MS/MS (liquid chromatography-tandem mass spectroscopy) was developed for simultaneous estimation of TBZ and CCC in wheat grains and harvest stage plant leaves. A total of 10 mL of acetonitrile and 50 mg of primary secondary amine (PSA) sorbent was consumed in the optimized QuEChERS process for leaves and grain samples. The LC-MS/MS analysis was performed using a C-18 column operating under electrospray ionization in positive mode. The QuEChERS approach achieved extraction recoveries in the acceptable range of 70%–120%, for both the compounds and was validated in terms of accuracy, precision, sensitivity and linearity. Persistence study was conducted using Lihocin (CCC 50% SL), Folicur (TBZ 25.9% EC) and their combination tank mix (Lihocin + Folicur-50% SL + 25.9% EC) applied as foliar spray twice in wheat crop (tester tall variety C-306). The results demonstrated that the developed QuEChERS-LCMS/MS is rapid and confirmatory for simultaneous quantification of both the test analytes in wheat crop.
[Role of growth arrest-specific protein 6 in migration and osteogenic differentiation of human periodontal ligament cells].

OBJECTIVE To investigate the role of growth arrest-specific protein 6 (Gas6) in the process of the migration and osteogenic differentiation of human periodontal ligament cells (hPDLCs). METHODS After different concentrations of recombinant human Gas6 (rhGas6) were added to hPDLCs, cell prolife-ration experiment (CCK-8) was taken to observe the effect of rhGas6 on hPDLCs cell proliferation. Scratch test and cell migration test (Transwell) were taken to analyze the migratory ability of hPDLCs in different concentrations of rhGas6 groups. After osteogenic induction, real-time quantitative polymerase chain reaction (real-time PCR) was taken to detect the expression of the Runt-related transcription factor 2 (Runx2) and alkaline phosphatase (ALP). ALP staining was used to detect the amount of mineralized nodules. RESULTS After adding different concentrations of rhGas6, there were no statistically significant differences in hPDLCs cell proliferation among the experimental groups and the control group at 24, 48 and 72 hours (P>0.05). After 24 h of scratch, the healing area in the 800 μg/L of the rhGas6 group was greater than that in the control group, but without statistically significant difference (31.06%±13.70% vs. 21.79%±9.51%, P>0.05). In the migration test, after 24 h, the number of hPDLCs cells which penetrated through the membrane in the 800 μg/L rhGas6 group was significantly higher than that in the control group (P < 0.01). After rhGas6 was added and osteogenic induction, Runx2 and ALP gene expressions of hPDLCs in the 800 μg/L group were significantly higher than those in the control group (1.60±0.30 vs. 0.91±0.10, 2.81±0.61 vs. 0.86±0.12, P < 0.01). After Gas6 was knocked down, the ALP expression of hPDLCs was significantly lower than that of the control group (0.39±0.07 vs. 0.92±0.14, P < 0.01). There was no significant change in Runx2 expression (P>0.05). After 7 days of osteogenic induction, the mineralized nodules formed in the Gas6 knockdown group were significantly less than those in control group (0.25±0.04 vs. 1.00±0.11, P < 0.001). After 14 days of induction, the staining degree of the Gas6 knockdown group was lower than that of the control group, but there was no significant difference (0.86±0.04 vs. 1.00±0.16, P>0.05). CONCLUSION After downregulation of Gas6 gene, mineralized nodule formation was reduced and ALP gene expressions were decreased in the early stage of osteogenic induction (7 days). After addition of rhGas6, Runx2 and ALP gene expressions were increased and the number of cell migration was increased, suggesting that Gas6 might play a promoting role in the migration and osteogenic differentiation of human periodontal ligament cells.
Phase-controlled synthesis and gas-sensing properties of zinc stannate (ZnSnO3 and Zn2SnO4) faceted solid and hollow microcrystals

Well-defined faceted zinc stannate, including cubic ZnSnO3 and octahedral Zn2SnO4, microcrystals were synthesized in a large scale by a one-step chemical solution route, in which the phase control was simply accomplished by only changing stannic precursors. These faceted cubic ZnSnO3 and octahedral Zn2SnO4 microcrystals are easily converted to faceted hollow structures with a shape preserved through an acid etching process. Possible growth and etching mechanisms of these faceted microcrystals have been proposed. The hollow structures of zinc stannate were exploited as gas sensors and exhibit improved sensing performances to a series of gases (especially with regard to H2S and C2H5OH); moreover, the sensitivity and recovery time of Zn2SnO4 hollow octahedral structures to H2S and C2H5OH are both higher than those of the cubic structures, which may find potential industrial applications in detecting gases.
Durability of Sulfonated Polyimide Membrane Evaluated by Long-Term Polymer Electrolyte Fuel Cell Operation

A novel proton conducting polymer electrolyte membrane, sulfonated polyimide having aliphatic moieties (SPI-5), was subjected to long-term fuel cell operation. High durability of the SPI-5 membrane was confirmed by single-cell testings at 80°C for 5000 h. Still, the SPI-5 membrane turned out to be fragile after the cell operation. Through the investigation of the changes in thickness, ion exchange capacity, molecular weight, and NMR spectra, it was concluded that the most probable degradation mode of the sulfonated polyimide membrane should be the hydrolysis of imide linkages, while oxidative degradation is also likely to be involved.
Effects of Size and Capping Reagents on Biexciton Auger Recombination Dynamics of CdTe Quantum Dots

CdTe quantum dots (QDs) were synthesized using oleic acid (OA) and thioglycolic acid (HS-CH2COOH, TGA) as capping reagents. Biexciton Auger recombination of CdTe QDs was examined by femtosecond transient absorption spectroscopy by changing excitation intensity. The lifetime of biexciton Auger recombination τAuger was analyzed as a function of QD diameter D and capping reagents. It was found that τAuger is proportional to Dα, and that the scaling index α is dependent on capping reagents and/or surface conditions. For TGA capped CdTe QDs, α is determined to be 4.6, whereas it is 7.0 for OA capped CdTe QDs with high luminescence quantum yields Φ of 60−85%. This relationship did not hold for small size OA capped CdTe QDs with rather low Φ of 15−30%, in which τAuger became as short as 2∼3 ps irrespective of the diameter. These results suggest that biexciton Auger recombination of CdTe QDs is strongly dependent on the QD surface trapping and capping reagents.
Is Submucosal Injection Helpful in Cold Snare Polypectomy for Small Colorectal Polyps?

Background/Aims Cold snare polypectomy (CSP) is an effective method of polyp removal for small colorectal polyps. However, the effect of submucosal injection in cold snare endoscopic mucosal resection (CS-EMR) for small polyps is unclear. Therefore, this study aimed to evaluate the effect of submucosal injection in CS-EMR for small polyps. Methods Between 2018 and 2019, 100 consecutive small colorectal polyps (5–10 mm) were identified in 58 patients. The first 50 consecutive polyps were removed by CS-EMR, and the remaining 50 were removed by CSP. Demographic data, clinical data, endoscopic findings, procedure times, complication rates, and pathology data were collected. Results No difference in the complete resection rate was observed between the CS-EMR and CSP groups. A total of 9 polyps showed post-polypectomy bleeding (7 had immediate bleeding, 1 had delayed bleeding, and 1 had both immediate and delayed bleeding). No difference in the bleeding rate was observed between the two groups. In multivariate analysis, warfarin (odds ratio [OR], 42.334; 95% confidence interval [CI], 1.006–1,781.758) and direct-acting oral anticoagulants (OR, 35.244; 95% CI, 3.853–322.397) showed a significantly increased risk of bleeding. Conclusions The effect of submucosal injection in CSP was not significant for small colorectal polyps.
Confirmation of Poly(1,3-dioxolan-2-one) Degrading Microorganisms in Environment

Ecological biodegradability of aliphatic polycarbonates in different environments was estimated by the clear-zone method with an agar medium containing emulsified polycarbonates. It was found that poly(1,3-dioxolan-2-one) can be degraded by microorganisms in certain limited environments.
31—SHAPE AND STRUCTURE IN TEXTILES

The aims and purposes of studies of the structure and geometry of yarns and fabrics are reviewed. An indication is given of the magnitude of the effect that internal structure can have, and the factors that define the shape of the structural units in a fabric are demonstrated. The influence on textile processing of the factors that determine yarn and cloth structure is discussed.
Sports performance adaptations through occlusal splint: Case reports of triathlon athletes

ABSTRACT Objective Occlusal disturbances affect human posture and sports performance. This study aimed to monitor biomechanical adaptations to personalized occlusal splints. Methods Splints were customized based on stabilometry, thermography, sEMG, and kinesiography, and administered to three triathlon athletes. They were evaluated during a 4-month period, using isokinetic indexes, running kinematics and anaerobic outputs. Results Individuality emerged as a key factor driving type, quantity, quality, and time trajectories of adaptations. The use of instrumental and clinical tests allowed the detection of static balance and biting function improvements, but not necessarily parallel to sports performance improvements. Conclusion The authors argue that strength and kinematic imbalances are joint and task-specific and support the use of multi-stage monitoring of the biomechanical effect of mouthpieces. Kinematics of cycling and running may be widely assessed with ecological and inexpensive methods. Strength imbalances need to be continuously monitored due to the high informative value to injury prevention.