Miracle-dz/UniFAR-FTUs huggingface dataset:
CD4+ and CD8+ T lymphocytes both contribute to acquired immunity to blood-stage Plasmodium chabaudi AS

In the present study, the contribution of CD4+ and CD8+ T lymphocytes to acquired immunity to blood-stage infection with the murine malaria species Plasmodium chabaudi AS was investigated. C57BL/6 mice, which are genetically resistant to infection with this hemoprotozoan parasite and exhibit a transient course of infection, were treated intraperitoneally with monoclonal antibodies to T-cell epitopes, either anti-Thy-1, anti-CD4, or anti-CD8. After intraperitoneal infection with 10(6) parasitized erythrocytes, control C57BL/6 mice exhibited a peak parasitemia on day 9 of approximately 35% parasitized erythrocytes and eliminated the infection within 4 weeks. Mice depleted of Thy-1+ or CD4+ T cells had significantly higher parasitemias on day 7 as well as significantly higher peak parasitemias. These mice were unable to control the infection and developed a persistent, high parasitemia that fluctuated between 40 and 60% until the experiment was terminated on day 56 postinfection. Depletion of CD8+ T lymphocytes was found to have no effect on the early course of parasitemia or on the level of peak parasitemia. However, mice depleted of CD8+ T cells experienced two recurrent bouts of parasitemia during the later stage of the infection and required more than 5 weeks to eliminate the parasites. After the peak parasitemia, which occurred in control and experimental animals on day 9, there was a sharp drop in parasitemia coinciding with a wave of reticulocytosis. Therefore, the contribution of the influx of reticulocytes, which are not the preferred host cell of this hemoprotozoan parasite, to limiting the parasitemia was also examined by determining the course of reticulocytosis during infection in control and T cell-depleted animals. Early in infection, there was a marked and comparable reticulocytosis in the peripheral blood of control and T cell-depleted mice; the reticulocytosis peaked on day 12 and coincided with the dramatic and sudden reduction in parasitemia occurring in all groups. In both control and CD8-depleted mice the percentage of reticulocytes decreased as the infection was resolved, whereas in CD4-depleted mice marked reticulocytosis correlated with high, persistent parasitemia. These results thus demonstrate that both CD4+ and CD8+ T cells are involved in acquired immunity to blood-stage P. chabaudi AS and that the influx of reticulocytes into the blood that occurs just after the peak parasitemia may contribute temporarily to limiting the parasitemia.
English to Sanskrit machine translation system: a rule-based approach

The development of machine translation (MT) system for ancient language such as Sanskrit is a much more fascinating and challenging task. Due to lack of linguistic community, there are no wide works accomplished in Sanskrit translation while it is national language by virtue of its importance in India's cultural heritage. This paper describes a rule-based approach of machine translation which translates an English sentence (source language sentence) into equivalent Sanskrit sentence (target language sentence). Due to morphological richness of Sanskrit language, this system makes limited use of syntax and uses only morphological markings to identify subject, object, verb, preposition, adjective and adverb, as well as conjunctive sentences. It uses limited parsing for part of speech (POS) tagging, identification of clause, its subject, object, verb, etc and gender-number-person (GNP) of noun and object. This system gives translation result in GUI form and handles English sentences of different classes. The performance evaluations of our EST system with different methods of MT evaluations are shown using table and column chart.
The glucose uptake kinetics of some marine bacteria.

The kinetics of glucose uptake by marine microbial populations have been investigated. Pure cultures were used in an attempt to define the conditions affecting uptake kinetics. The use of routine marine microbiological media did not isolate microorganisms capable of responding to the substrate levels that one might expect to find in the ocean, but a chemostat approach was successful in the isolation of such forms. Some factors affecting the uptake of glucose at very low levels were investigated. The kinetic approach with pure cultures has possible application as a bioassay method for substrates in low concentrations in seawater. The ecological significance of the investigation is discussed.
Total Quality in Managing Human Resources

Why Total Quality in Managing Human Resources? Driving Forces Reshaping the Human Resource Environment A Brief History of U.S. Human Resource Management The House of Total Quality: The Challenging Opportunity for Human Resources Ethical Work Culture and Expanded Human Resource Roles Human Resource Management and the Total Quality Difference Barriers and Responses to Total Quality Human Resource Management Implementation Review/Discussion Questions Endnotes Appendix Customer Satisfaction: Strategy Dimensions The Total Quality Business Strategy Total Quality Business Strategy Planning Total Quality Business Strategy Management The Total Quality Human Resource Strategy Total Quality Human Resource Strategy Planning Total Quality Human Resource Strategy Management Review/Discussion Questions Endnotes Practitioner Assessment Instruments Continuous Improvement: Process Dimensions The Total Quality Business Processes Total Quality Business Process Planning Total Quality Business Process Management Total Quality Human Resource Processes Total Quality Human Resource Process Planning Total Quality Human Resource Process Management Review/Discussion Questions Endnotes Practitioner Assessment Instruments Speaking with Facts: Project Dimensions The Total Quality Business Projects Total Quality Business Project Planning Total Quality Business Project Management Total Quality Human Resource Projects Total Quality Human Resource Project Planning Total Quality Human Resource Project Management Review/Discussion Questions Endnotes Practitioner Assessment Instruments Respect for People: Performance Dimensions The Total Quality Business Individual Performance Total Quality Business Performance Planning Total Quality Business Performance Management Total Quality Human Resource Performance Total Quality Human Resource Performance Planning Total Quality Human Resource Performance Management Review/Discussion Questions Endnotes Practitioner Assessment Instruments Implementing Total Quality Human Resource Management Total Quality Integrated Implementation Plan for Managing Human Resources The MichCon Case: A Snapshot of Successful Total Quality Human Resource Management International Implementation of Total Quality Human Resource Practices Review/Discussion Questions Endnotes Minicases Index
Pandora Radio: Fire Unprofitable Customers?

Pandora Radio is at a crossroads. Founder Tim Westergren has just been told by a well known VC to get rid of his unprofitable customers in order to get his costs down, but Westergren is not sure that such actions are consistent with his company's business model. Pandora Radio is the largest Internet music stream site, and its rapidly growing user base loves the free customizable music stream under an advertising supported model. Pandora has to pay royalties for every song streamed, and has other variable costs that scale linearly with hours consumed, but it has taken no steps to restrict the amount of usage among its heaviest and most loyal users. Can Pandora make its model work when a significant percentage of its users cause it to lose money?
Accelerometer-Based Gait Analysis, A survey

From a technological perspective, biometric gait recognition can be categorized into three approaches: Machine Vision based, Floor Sensor based and Wearable Sensor based. This survey covers historical development and current state of the art in accelerometer-based gait analysis, a sub-category of wearable sensor based gait recognition. It gives an all-around literature study describing the major modules; experiments, data acquisition, data analysis and comparison of gait representations.
Exploring e-Governance in the network industries

Since the 1980s the network industries (post, telecom, electricity, air and rail transport, and water) worldwide are undergoing substantial transformations. These transformations have been triggered by institutional changes in both property regimes and coordination mechanisms (unbundling and subsequent competition in the liberalized segments of these industries). The paper argues that the governance of these liberalizing network industries has not really followed suit, leading to a significant institutional governance deficit of these industries with often serious consequences (safety, security of supply, etc.). The paper furthermore argues that the active use of the ICTs in the governance of these liberalizing network industries is still seriously undervalued, but that the ICTs hold significant potential for improving network industry governance. After making the case for such an e-governance of the network industries from a theoretical point of view, the paper will then illustrate current practices of e-governance of the network industries by means of mini case studies. It will finally outline the potential for a future systematic and in-depth usage of the ICT for purposes of governance of the network industries.
The influence of corporate disclosure on investor confidencein Thai listed companies

The thesis is a study of corporate disclosure and stock market liquidity in Thailand. It uses a two-phase exploratory design in which the results from the qualitative method phase of the study are used to inform the quantitative method phase. The qualitative phase of the study aims to gain an understanding of corporate disclosure and the sources of information used of by financial analysts and the fund managers in Thailand. Specifically, it explores the use financial analysts and fund managers make of different sources and channels of communication, and their views on the purpose and the quality of disclosure and of the reasons why companies may choose to disclose information voluntarily. It also explores financial analysts’ and fund managers’ perceptions about the value of the audit report. The qualitative study is based upon interviews with financial analysts and fund managers working in Thailand and uses grounded theory to analyse the interview material. The quantitative phase of the study examines the relationship between the voluntary information disclosure by Thai listed companies and stock market liquidity. In particular, it examines the relationship between stock market liquidity and: (i) categories of information disclosure; and (ii) channels of information disclosure. It also examines the relationship between information disclosure and: (i) audit firm size, and (ii) analyst following. Disclosure is measured in two ways: first using ratings by financial analysts and fund managers of companies’ public and private disclosures and second by means of a disclosure index. Stock market liquidity is measured using information obtained from the Stock Exchange of Thailand ‘SET Market Analysis and Reporting Tool’ database. The empirical results show strong evidence to indicate that disclosing more voluntary information, particularly through public disclosure, reduces information asymmetry, improves investor confidence and enhances the stock market liquidity. In addition to the results of the primarily investigation, this study also finds that there is a significant and positive relationship between the audit firm size and the level of voluntary information disclosure. Moreover, the results report that not all sections of information disclosure are related to the size of analyst following
How Hotel Guests Perceive the Fairness of Differential Room Pricing

When customers perceived hotel revenue management practices to be fair, they are more likely to be satisfied with the hotel and are more likely to return to that hotel in the future. In this survey of 815 people, we examined the effects of three factors on the respondents’ assessment of the fairness of hotel rate policies. Those three factors were familiarity with the practice, provision of information about the practice, and the brand class of the hotel. Of those three, we found that familiarity with a pricing practice was far and away the most important factor affecting perceived fairness. The implication is that revenue managers should focus their efforts on increasing guests’ familiarity with their pricing practices.
Proline Reaction , Peroxide Activity and Antioxidant Enzymes in Varieties of Maize ( ZEA MAYS L . ) Under Different Levels of Salinity

Investigate the effects of salt stress on some physiological and morphological traits in four varieties and four salinity levels, including SC302, SC700, BC662, SC704 and Zero (control), 50, 100 and 150 mM NaCl in three replicates for the factorial experiment in randomized complete block design was carried out. During the experiment, several traits including plant height, chlorophyll a, chlorophyll b, proline and antioxidant enzymes were measured. For the trait days to germination at different levels of salinity significantly different at 5% probability level was seen. Interactions between genotypes and salinity in a significant difference was found. Between different levels of salinity on chlorophyll trait in a significant difference was seen in 1% level. Between different levels of salinity in catalase showed a significant difference. Between genotypes of the enzyme ascorbate peroxidase significant difference was seen, But genotypes showed not significant difference in amount of proline. The most plant height was obtained at zero salinity and with increasing salinity decreased plant height. Maximum chlorophyll a in normal conditions was found in S.C704 with 1.27 mg of chlorophyll per gram fresh weight of leaves. Superoxide dismutase with increasing salinity stress in all genotypes increased. With increasing salinity, the amount of catalase increased and at 100 mM salt stress reached a maximum. Maximum catalase was measured in 100 mM salt in BC666, that with SC302 and SC700 was not significantly different. The least amount of catalase in normal conditions in s.c704 and sc700 respectively 0.3567, 0.3533 units min g fresh weight of leaves was obtained. Of the enzyme ascorbate peroxidase, the enzyme in the greatest amount of salt concentration in 50 mmol in Sc302 with 3.73 units min g fresh weight of leaves was obtained. Lowest of these enzymes in salinity third in s.c704 was obtained. Most of proline, was obtained in 100Mm in variety SC302 with 537 micromole. Between proline and catalase positive and significant correlation was obtained. In other words with increasing salt stress also increases the amount of enzymes. Significant positive correlation was found between the enzyme ascorbate peroxidase and proline.
Fitness for Work

PROF. PEAR has in this little book made an interesting study of fitness for work. He rightly remarks that far more books are written about unfitness. He analyses the aspects of successful achievement which force us to attribute to a worker capacities, abilities, or skills, and then the motives that lead a person to select, continue in, or change a particular work, and finally discusses some current conceptions of the function of work. Stupidity and laziness would almost seem to be out of place in a study of fitness, but the author presents some novel and provocative remarks on the two and shows their relation to such a theme. The final chapter on the question of the value of industrial skill opens up some very vital problems of modern industry. Two apparently opposite tendencies are clearly visible in the modern State: on one hand, there is an undoubted increase in the application of mechanism, with a corresponding diminution in the need for personal skill, but on the other, the very mechanism itself demands more people to adapt and adjust it, that is, to deal intelligently with mechanism, and modern organisations demand still greater skill on the part of those in authority.Fitness for Work.By Prof. T. H. Pear. Pp. 187. (London: University of London Press, Ltd., 1928.) 5s. net.
Mixed and Circular Multichromosomal Genomic Median Problem

We study the problem of finding the breakpoint median for multichromosomal unsigned genomes that contain circular or mixed (circular and linear) chromosomes. It has been shown by Tannier, Zheng, and Sankoff that for signed multichromosomal circular or mixed genomes the breakpoint median can be found in polynomial time; however, the complexity of the unsigned versions of the problems were unknown. In this paper, we show that these problems can all be solved in polynomial time. We also study restricted versions of the multichromosomal breakpoint median problem where the number of chromosomes of the median must be a certain number. We show that as soon as we impose a fixed number of chromosomes the problem becomes NP-hard. Moreover, we introduce the notion of partially signed circular or mixed genomes, where both signed and unsigned genes may exist in the same genome. We provide the first study of this form of these breakpoint median problems and show that these problem can also be solved in polynomial time .
Population pharmacokinetics of paracetamol across the human age‐range from (pre)term neonates, infants, children to adults

In order to characterize the variation in pharmacokinetics of paracetamol across the human age span, we performed a population pharmacokinetic analysis from preterm neonates to adults with specific focus on clearance. Concentration‐time data obtained in 220 neonates (post‐natal age 1–76 days, gestational age 27–42 weeks), infants (0.11–1.33 yrs), children (2–7 yrs) and adults (19–34 yrs) were analyzed using NONMEM 7.2. In the covariate analysis, linear functions, power functions, and a power function with a bodyweight‐dependent exponent were tested. Between preterm neonates and adults, linear bodyweight functions were identified for Q2, Q3, V1, V2, and V3, while for CL a power function with a bodyweight‐dependent exponent k was identified (CLi = CLp × (BW/70)k). The exponent k was found to decrease in a sigmoidal manner with bodyweight from 1.2 to 0.75, with half the decrease in exponent reached at 12.2 kg. No other covariates such as age were identified. A pharmacokinetic model for paracetamol characterizing changes in pharmacokinetic parameters across the pediatric age‐range was developed. Clearance was found to change in a nonlinear manner with bodyweight. Based on the final model, dosing guidelines are proposed from preterm neonates to adolescents resulting in similar exposure across all age ranges.