Miracle-dz/UniFAR-FTUs huggingface dataset:
One-year Risk of Stroke after Transient Ischemic Attack or Minor Stroke

According to studies between 1997 and 2003, the risk of stroke or acute coronary syndrome after a “transient ischemic attack” (TIA) or minor stroke ranges between 12-20% (1,2). Currently, patients are triaged depending on stroke risk, which is calculated using age, blood pressure, clinical symptoms, duration of symptoms, and presence of diabetes (ABCD2). If ABCD2 is equal to or higher then 4, emergency care is recommended for 24 hours starting from the beginning of the symptoms (3). Although important developments took place in the management of TIA after 2003, the prognosis of the disease and role of risk scoring systems in emergency care has not yet been clearly established. Therefore, the TIAregistry.org project was developed to define the current profile and etiologic factors, to determine short(1 year) and long-term (5 years) outcomes, and to re-evaluate risk. The “One-year risk of stroke after TIA or minor stroke” trial by Amarenco et al. (4) reported some of the data obtained by the TIAregistry.org project. This project was conducted in 61 centers in 21 countries and included patients who had TIA or minor stroke within 7 days of being examined by a stroke specialist. Between June 2009 and December 2011, 4789 patients were registered for the study. Of these, 4583 were included in the analyses and 3593 (78.4%) were evaluated by a stroke specialist during the first 24 hours after the event. The mean age of the patients was 66.1±13.2 years and the median duration of hospital stay was 4 days. The mean ABCD2 score for patients who were evaluated during the first 24 hours was 4.7±1.5, and for patients who were evaluated after the first 24 hours it was 3.8±1.6 (p<0.001). This study found acute cerebral infarction in 33.4% of patients, at least one extracranial or intracranial stenosis in 50%, and atrial fibrillation in 10.4% of patients. A Kaplan-Meier estimate for 1-year composite cardiovascular outcomes was 6.2% (95% confidence interval 5.5-7.0). Kaplan-Meier estimates for stroke rates on the 2nd, 7th, 30th, 90th, and 365th days were 1.5%, 2.1%, 2.8%, 3.7%, and 5.1%, respectively. Multivariable analyses revealed that each of multiple infarctions, large artery atherosclerosis, or ABCD2 score 6-7 increased stroke risk more than twice. Although the event rate was much lower than in historical cohorts, the ABCD2 score was still effective for risk determination in patients who were treated urgently and intensively. In addition, 22% of recurrent strokes were seen in patients with ABCD2 scores lower than 4 who had accompanying modifiable risk factors such as atrial fibrillation or 50% or more ipsilateral internal carotid artery stenosis.
Ege Üniversitesi Hastanesinde gastrointestinal sistem kanserlerinin epidemiyolojik ve sağ kalım özellikleri

Amac: Ege Universitesi Hastanesi (EUH)’nde 1992-2017 arasi gastrointestinal sistem (GIS) kanseri tanisi ve tedavileri yapilan olgularin epidemiyolojik ve genel sag kalim (GSK) ozelliklerinin degerlendirilmesidir. Gerec Yontem: EUKAM tarafindan 1992-2017 yillari arasinda 19.542 GIS kanser kaydi yapilmistir. Siniflandirmalarda ve sag kalim analizlerinde SEER verileri goz onune alinmistir. CANREG 4 programi ile kaydedilen veriler SPSS programina aktarilmis, istatistik analizde Ki-kare yontemi ve dogrusal modellemeler yapilmis, p 70 yas grubunda (%28,6) anlamli yuksektir (ki-kare: 85,297; p<0,0001). Yirmi yas ve uzeri eriskin ve cocukluk donemi kanser yerlesimleri karsilastirildiginda, cocuklarda karaciger ve intrahepatik safra yollari (%60,9), eriskinde KRK ilk siradadir (%37,4) (p<0,00019). Histopatolojik olarak en sik adenokanserler (%70) gorulmektedir (p<0,0001). GIS kanserlerinde yillara gore dogrusal bir artis saptanmistir (p<0,0001). Sonuc: EUH Kanser Kayit sisteminde GIS kanserleri tum sistemler arasinda birinci siradadir. GIS kanserleri icinde en sik KRK gorulmekte, bunu mide kanserleri izlemektedir. KRK kadinlarda, mide kanseri erkeklerde daha siktir. GIS kanserleri hastanemizde cinsiyete ve yillara gore dogrusal bir artis gostermektedir. GIS kanserlerimizde ortalama sag kalim 25 ay, bes ve 10 yillik GSK oranlari %33,6 ve %25,2’dir.
‘I felt so removed from student teaching’: shared voices of preservice student teachers regarding the edTPA and student teaching

ABSTRACT Guided by an inquiry as stance approach, this study aimed to explore the perspectives of early childhood and elementary pre-service student teachers on the impact of the edTPA (Teacher Performance Assessment) on their student teaching experiences. The analysis of an online open-ended questionnaire revealed that the claims made by the edTPA supports were paradoxical. Our participants shared the unforeseen effects of the edTPA on their student teaching experiences, such as the [non-]educative, [un]authentic, and [un]professional side of the edTPA. The findings of this study urge teacher educators, policy makers, and administrators to rethink and re-examine the edTPA requirement in the field to provide truly professional and educative experiences for all young children, student teachers, Cooperating Teachers (CT), staff, and the community.
Antagonistic roles of NOT1 paralogues in the timing of gene expression in Plasmodium falciparum

NOT1 is the scaffold of the CCR4-NOT complex, a highly conserved multi-protein complex that regulates gene expression in eukaryotes. As opposed to most eukaryotes in which NO1 is encoded by a single gene, malaria parasites, Plasmodium falciparum, carry two NOT1 paralogues, PfNOT1.1 and PfNOT1.2. Here we showed that the two PfNOT1 proteins function as mutually exclusive scaffolds within the PfCCR4-NOT protein complexes that are abundantly located in the parasite cytoplasm. Intriguingly, the two PfNOT1 paralogues appear to have directly opposing functions in regulation of mRNA abundance across the P. falciparum IDC, in which PfNTO1.1 and PfNOT1.2 induces and suppresses transcript abundance during their active transcription, respectively. Targeted disruption of either of the PfNOT1 gene causes defective growth and lower invasion rates presumably due to the deregulation the P. falciparum IDC transcriptional cascade. We also demonstrate that the regulatory function of both PfNOT1.1 and PfNOT1.2 are related to another PfCCR4-NOT subunit, PfCaf1, which indicates their activity during post-transcriptional regulation. Indeed RNA decay studies suggest the active role of both PfNOT1 proteins in regulation of mRNA stability in a directly opposing manner. Author summary CCR4-NOT complex is a highly conserved multi-protein complex that regulates gene expression in eukaryotes. NOT1 serves as the scaffold of the complex and plays important roles in gene regulation both transcriptionally and post-transcriptionally. As opposed to other eukaryotes, P. falciparum encodes two paralogues of PfNOT1, raising the question as to the significance to possess an additional copy of PfNOT1 in the parasite. Here we described antagonistic regulatory functions of two PfNOT1 paralogues in gene expression during the 48-hour intraerythrocytic developmental cycle. We also reported that their regulatory functions are predominantly post-transcriptional and proposed a model in which distinct PfCCR4-NOT complexes defined by mutually exclusive PfNOT1 scaffolds differentially regulate PfCAF1 function in mRNA decay. This study highlights the importance of post-transcriptional regulation in P. falciparum and provides novel insights into mechanisms of gene regulation in this organism. The unique presence of two PfNOT1 paralogues may also open avenues for the development of new drug targets for anti-malarial control.
Gerência do Ciclo de Vida de VNFs e Implementação de Serviços Distribuídos na Rede

A Virtualização de Funções de Rede oferece uma alternativa flexível para projetar e gerenciar serviços de rede. Neste trabalho foi proposta a arquitetura de um VNF Manager (VNFM) para o gerenciamento do ciclo de vida de VNFs. O VNFM simplifica as operações de gerência e permite a interoperabilidade entre plataformas NFV. A segunda contribuição propõe a VNF-Consensus, uma VNF que sincroniza consistentemente o plano de controle distribuído em uma rede SDN. A VNF desacopla os mecanismos de sincronização, evitando a sobrecarga nos controladores. Por fim, a última contribuição é o AnyBone, um backbone virtual com serviços de difusão confiável e ordenada de mensagens implementados na própria rede. O AnyBone garante a ordem das mensagens através de um sequenciador, também implementado como uma VNF.
Are Extreme Negative Return Events Independent of the Market?

This study defines an extreme daily loss event as a daily return lower than 97.5% of their historical daily returns. We also define an extreme loss of an asset as forgivable if it happens during an extreme down market and as unforgivable if the concurrent market performance is normal. We find that half of extreme losses generated by the Russell 3000 components are forgivable, and the average forgivable loss is similar to the average unforgivable loss. After the S&P 500 Index experiences an extreme loss event, the 1-day and 5-day returns of assets that also undergo extreme losses concurrently are 0.9768% and 1.9495%, respectively. Without an overall market index extreme loss, the postextreme-loss recoveries of individual assets are 0.7171% and 1.6724%. Our results suggest that the high degree of equity market spectrum dispersion leads to independent individual asset price trajectories. We find that the counts of extreme loss events do not decrease linearly as the equity market performance escalates to higher percentile categories. TOPICS: Wealth management, performance measurement Key Findings • If an equity asset experiences extreme loss on a day when the equity market does not experience extreme loss, the average loss of the asset is −8.6344%, and the 1-day and the 5-day recovery returns are 0.7171% and 1.6724%, respectively. • If an equity asset experiences extreme loss on a day when the equity market experiences extreme loss concurrently, the average loss of the asset is −7.7803%, and the 1-day and the 5-day recovery returns are 0.9768% and 1.9495%, respectively. • Extreme loss events are relatively independent from the equity market performance, and better market returns do not reduce the occurrence of extreme loss events.
Spatially Biased Eye Movements in Older Drivers with Glaucoma and Visual Field Defects

Summary: Patients with glaucoma are at greater driving safety risk due to visual field defects. These driving safety risks may be mitigated by compensatory eye movements. We measured spatial allocation of eye movements in a panoramic driving simulator in 8 drivers with glaucoma and 5 with suspected glaucoma. All completed a driving simulator visual field task under three separate conditions: (1) parked with a naturalistic background (Baseline condition); (2) driving on a rural highway (Driving condition); and (3) driving and completing a competing auditory attention task (PASAT condition). Results showed that: (1) drivers with larger binocular visual field defects showed more restricted, spatially biased eye movements, and (2) greater task load led to more spatially biased eye movements in drivers with larger binocular visual field defects. Findings provide preliminary evidence of eye movement patterns that may reflect compensatory behaviors in drivers with glaucomatous visual fields. Better understanding of the relationship between visual field deficits, eye movement patterns, and driving in glaucoma can help inform countermeasures to improve safety and mobility in drivers with visual impairments.
A Simple Method to Avoid Post-Operative Dysphagia after Laparoscopic Nissen Fundoplication = طريقة بسيطة لتجنب عسر البلع بعد جراحة نيسين لتثنية قاع المعدة بالمنظار لعلاج ارتجاع المريء أو فتق الحجاب الحاجز

Background: Nowadays, in most surgical centers, Nissen fundoplication is the “gold standard” procedure for treatment of pathologic gastroesophageal reflux disease. Objectives: Comparing between fixation of fundal wrap to esophageal musculature and to the phrenoesophageal membrane, in laparoscopic Nissen fundoplication, as regard its effect on post-operative dysphagia. Patients and Methods: From May 2013 to December 2015, laparoscopic Nissen fundoplication was done for 49 patients for treatment of gastroesophageal reflux disease and/or hiatal hernia at New Damietta University Hospital. These 49 patients were randomly divided into two groups; (A) 24 patients underwent fixation of the fundal wrap to the esophageal musculature, and (B) 25 patients underwent fixation of the fundal wrap to the remaining part of the phrenoesophageal membrane over the abdominal part of esophagus. Results: Pre-operative dysphagia was present in 16 patients (66.7%) in group A {12 moderate and 4 mild}, and 15 patients (60%) in group B {11 moderate and 4 mild}. Post-operative dysphagia developed in 12 patients (50%) in group A {one severe and 11 moderate}, all of them got better gradually during the follow up period except one which needed dilation, and 5 patients (20%) in group B were moderate and gradually got better during the follow up period. Post-operatively, there was a recurrence of GERD in 5 patients (20.8%) of group A {3 patients with grade 1 improved spontaneously, one patient with grade 2 improved with PPI treatment, and one patient with grade 3 necessitated reoperation}. As regard group B, there was a recurrence of GERD in 3 patients (12%) {2 patients with grade 1 improved spontaneously, and one patient with grade 2 improved with PPI}. As regard recurrence of hiatal hernia, there was one (4.2%) recurrence in group A, and no one in group B. Conclusion: Success of surgical treatment of gastro-esophageal reflux disease and hiatal hernia will be achieved with good patient selection, correct choice of surgical procedure, and good quality performance of operation. Fixation of the fundal wrap to the phrenoesophageal membrane is preferable and good alternative to its fixation to muscle fibers of lower part of esophagus, as it decreased post laparoscopic Nissen fundoplication dysphagia and recurrence.
Anatomy, Head and Neck, Eye Orbicularis Oculi Muscle

The orbicularis oculi muscle is a muscle located in the eyelids. It is a sphincter muscle arranged in concentric bands around the upper and lower eyelids. The main function of the orbicularis oculi muscle is to close the eyelids. This occurs when the muscle contracts. It also assists in the drainage of tears from the eyes. Whenever the orbicularis oculi muscle contracts, the tears are drawn from the tear film via the lacrimal pump system.
Clear reporting of study design in a trial on patient education in psoriasis

Dear editor, With great interest, we read the publication ‚The effect of self-management education on the quality of life and severity of the disease in patients with severe psoriasis: A non-randomized clinical trial‘ by the authors Tahereh Najafi-Ghezeljeh, Kobra Soltandehghan and Agha-Fatemeh Hosseini (1). As active researchers in the areas of psoriasis and self-management we welcome studies in these areas and congratulate the authors on successfully conducting this study. We would like to invite the authors to clarify the somewhat conflicting reporting concerning study design. It is clearly stated in the title that this is ‚A non-randomized trial‘ and in the methods section we read: „The patients were assigned into the control and intervention groups using simple randomization. Accordingly, the patients hospitalized in the first and second half of each month were recruited in the intervention and control groups, respectively “(1). Upon investigation of the Iranian Registry of Clinical Trials we discover that “This study is a randomized clinical trial and single blind research with a control group [. ]” (2), unfortunately the description of the randomization method had been left blank. We regret that the peer review process of Nursing Practice Today did not lead to a clarification of the study design. This is of particular importance for systematic reviewers, because studies need to be assessed for risk of bias applying the correct assessment instrument (3-4).
The mechanisms of antibiotic resistance in clinical isolates of Acinetobacter, with special reference to carbapenem resistance

The most recent class of P-lactams, the carbapenems, have been an effective treatment for infections caused by multi-resistant strains ofAcinetobacter baumannii however, there are now increasing reports of emerging carbapenem-resistant isolates world-wide, which severely threatens the successful treatment of patients infected by these bacteria. The mechanism of this resistance in Acinetobacter spp. has been attributed to a combination of reduced outer membrane permeability and loss of outer membrane proteins. More recently however, several reports have identified P-lactamases as a major mechanism. The main aim of this thesis was therefore to ascertain the importance of P-lactamase activity as a mechanism of carbapenem resistance in clinical isolates ofAcinetobacter from several countries. A total of 54 clinical isolates from Argentina, Turkey, Hong Kong, Spain and Singapore were investigated. The majority of isolates were identified as A. baumannii. Antimicrobial susceptibility testing detected resistance in all isolates to the majority of antimicrobials tested. A total of 69% of isolates demonstrated MIC values of imipenem above the recommended breakpoint value, of which the highest percentage resistance was observed in the isolates from Argentina and Singapore (89% and 82% respectively). A significantly lower level of resistance (38.9%) was observed to meropenem. A modified microbiological assay detected imipenem inactivation in all imipenem-resistant isolates, of which 61% produced an unknown P-lactamase of pi 7.0 (main band). Inhibitor overlays of IEF gels demonstrated that this P-lactamase was a serine active-site enzyme that was able to bind imipenem. Kinetic studies with a crude p-lactamase extract of representative strain 790 failed to detect imipenem hydrolysis. A modified assay was subsequently employed to detect hydrolysis over a longer period of time. The rate of hydrolysis was calculated as 0.75 nmoles min"1 ml"1 of sample and the specific activity as 0.055 nmoles min"1 mg"1 of protein. Curing experiments with isolate 790 resulted in the loss of the p-lactamase of pi 7.0 and a subsequent reduction in the MIC value of imipenem to a susceptible level (16 mg/L to
Resistance to bevacizumab in ovarian cancer SKOV3 xenograft due to EphB4 overexpression

Aim of Study: Bevacizumab (BV) is broadly used to treat a number of cancers; however, BV resistance mechanisms and strategies to overcome this resistance are yet to be determined. Materials and Methods: In this study, we used ovarian xenograft model to evaluate the underlying resistance mechanisms of BV in ovarian cancer treatment. Results: Our results showed that EphB4 was overexpressed in BV-resistant xenograft models instead of other common receptor tyrosine kinases. In addition, when coadministrated with EphB4 blocker NVP-BHG712, the antitumor effect of BV was significantly enhanced in the resistant model, further confirmed the role of EphB4 in BV-resistant ovarian cancer. These results indicate that NVP-BHG712 reverses EphB4 overexpression-mediated resistance to BV. Conclusion: These findings represent a guide for the design of future medication strategy and may be useful in guiding the use of BV in combination with NVP-BHG712 in patients with resistance or intolerance ovarian cancer.
Detailed facies analysis of Cenomanian–Turonian organic‐rich mudstones: Implications for depositional controls on source rocks

Understanding mudstone depositional processes, including both traction transport and dynamic mechanisms, requires a re‐assessment of how these processes relate to the accumulation and preservation of organic carbon in fine‐grained successions. This relationship was addressed using facies described in detail from a Cenomanian–Turonian aged, organic‐rich, marine mudstone‐dominated succession from the Albertan Western Interior Seaway. All facies exhibit a high degree of heterogeneity at the millimetre‐to‐decimetre scale, contain evidence of bioturbation and display similar ranges of sedimentary structures including wave ripples and current ripples, sharp‐based graded beds and starved ripples. Described facies vary in grain size as well as relative abundances of biogenic versus siliciclastic grains. Siliciclastic grains are dominantly composed of quartz silt as well as silt‐sized to sand‐sized clay mineral–rich aggregates while the biogenic grains are dominantly composed of silt‐sized to sand‐sized calcareous pellets, bivalve fragments and foraminifera. Although the succession is relatively clay mineral‐rich, the majority of clay minerals occur as mud aggregates that were transported by traction processes. The sedimentary structures present are diagnostic of sea floor reworking by waves and currents, indicating that the basin was relatively shallow (i.e. not hundreds of metres deep) with frequent reworking of the sea floor sediment with suspension settling deposits being rare. The abundance of bioturbation and in situ bivalves indicates that there was sufficient oxygen at the sea floor and that widespread bottom water anoxia was not persistent at the time of deposition of the organic‐rich interval of interest. The accumulation of organic‐rich sediment appears to be a preservational phenomenon caused by sediment being buried more rapidly than the organic carbon can oxidize in the surficial layers due to episodic inputs of siliciclastic material during large storm events.
MODELLING TECHNICAL COUNTERMEASURES OF ADVANCED PERSISTENT THREATS

An advanced persistent threat (APT) is a highly targeted and sophisticated attack directed at the internetworked computer user at the workplace. They typically employ zero-day malware, stealth, and multiple advanced techniques to gain entry and maintain presence undetected inside the network. As a result, preventing their ingress at the network perimeter and detection once infiltration occurs, continues to be a challenge. In this respect, the major objective of this research is to propose a classification schema for the APT technical countermeasures. We interviewed senior managers working in government and private organizations in the United Arab Emirates over a period of four years (2014 to 2017) to gain their perspective of the threat and elicit technical countermeasures. We anticipate the proposed methods and practices can assist organizations, not only in the UAE but also in the wider global context, to implement an appropriate mix of countermeasures for APT threats from a multi-dimensional perspective.
What Are the Goals of Lipid Testing?

Lipids can be measured for immediate diagnostic purposes in which a dyslipidemia is in the differential diagnosis of the patient's presenting complaint. For example, a fasting lipid profile (specifically including triglycerides) would be appropriate in a patient presenting with acute pancreatitis of unclear origin (supposing that alcohol exposure, cholelithiasis, and trauma were excluded). Lipid screening for general cardiovascular risk assessment at frequencies accepted by clinical societies and payers alike remains the most common reason for measurements such as “the lipid profile (1). ” Rarely, lipids are measured in search of hypolipidemia (e.g., possible causes of abetalipoprotienemia or hypobetalipoproteinemia). ### How can lipid testing be classified? The traditional lipid assessment is the “lipid profile,” sometimes referred to as a “lipoprotein profile. ” We can group lipid testing into (1) standard tests, (2) supplemental standard tests (3 …