Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of tibia avulsion fracture of posterior cruciate ligament with total arthroscopic internal fixation with adjustable double loop plate: A retrospective cohort study.

AIM To evaluate the effects of treating tibia avulsion fracture of the posterior cruciate ligament (PCL) by internal fixation with an adjustable double loop plate under the arthroscopic. METHODS Patients with a tibia avulsion fracture of the PCL were identified and were divided into two groups. X-ray, CT, and magnetic resonance imaging (MRI) were used to evaluate the injury and the fixation of the knee. The results of the range of motion (ROM), Lysholm score, International Knee Documentation Committee (IKDC) score, KT-1000, and other clinical parameters were checked and recorded, and compared through the study. RESULTS A total of 26 patients were identified in this study according to the inclusion and exclusion criteria. The initial fixation was achieved the fracture fragments were well fixed in all patients and the fracture healed at 3 months postoperatively. The demographics and baseline characteristics showed no differences. There were no differences between the experimental group and the control group in IKDC score (54.1±6.2 vs. 53.2±7.1, P = 0.812), Lysholm score (37.5±4.1 vs. 36.8±2.5, P = 0.636), KT-1000 score (9.8±0.6 mm vs. 9.6±0.4 mm, P = 0.401), and ROM (30±4.5˚ vs. 31±3.7˚, P = 0.723) before the surgery. Compared with the preoperative results, in the experimental group, the postoperative ROM (133.5±6.3˚, P<0.001), Lysholm scores (84.3±5.2, P = 0.001), and IKDC scores (4.5±5.1, P = 0.001) increased, and the postoperative KT-1000 scores (1.6±0.4, P = 0.001) declined, there was a significant difference. Accordingly, in the control group, the postoperative ROM (131±4.2˚, P<0.001), Lysholm scores (81.5±3.2, P = 0.001), and IKDC scores (83.6±3.7, P = 0.001) increased, and the KT-1000 scores (1.7±0.5, P = 0.001) decreased, with a significant difference. The postoperative outcomes, ROM, Lysholm scores, IKDC scores, and KT-1000 scores showed no significant differences between the two groups (P>0.799). CONCLUSIONS Compared with the conventional method, arthroscopic internal fixation with an adjustable double loop shows promise but requires further study.
Tau prion strains in cells, mice, and patients

viii Chapter 1: Introduction and Perspective.1 1.1 Preface.2 1.2 Neurodegenerative Diseases: Distinct Syndromes, Striking Similarities.3 1.3 Prion Concept as Paradigm for Neurodegenerative Spread.6 1.4 Mechanisms of Trans-Cellular Prion Propagation.13 1.5 Strains: Amyloid Structures Drive Phenotypes.17 1.6 Phenotypic Diversity in Non-Infectious Neurodegenerative Diseases.23 1.7 The Current Perspective.26 1.8 Summary.28 1.9 Figures.29 Chapter 2: Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies.35 2.1 Preface.36 2.2 Abstract.37 2.3 Introduction.38 2.4 Materials and Methods.41 2.5 Results.63 2.6 Discussion.75 2.7 Figures.81 Chapter 3: Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo.121
Application of ultrasonics for nanosizing drugs and drug formulations

Abstract Ultrasonication (US) is a modern technology that is routinely applied for a variety of laboratory tasks, from cleaning contaminants inside pores and cracks, to dispersion of solids, particle size reduction, emulsification, chemical reactions, and even cell disruption. It is fast, clean, affordable, and safe, requires minimal space and can be operated as a batch or a continuous process. In the last few decades, a number of articles have been published reporting the use of US as a single method or in combination with others for the nanosizing drug formulations aiming at solubility and permeability improvement. In this review, the different application modes and the principles of operation of the relevant apparatuses are presented. The effects of processing parameters on the efficiency of the method are described in association with the characteristics of the sonicated dispersion. In the last sections, the application of US in the pharmaceutical field is demonstrated by many examples which prove its capability to assist with bioavailability and therapeutic problems by presenting the drugs as nanosized formulations for different routes of administration. Graphical Abstract
Dyes Extracted From the Seeds of Eruca Sativa, Nigella Sativa and Ammi Visnaga as Photosensitizers for Dye-Sensitized Solar Cells

In this work, the extracts of three natural dyes obtained from the seeds of Eruca Sativa, Nigella sativa, and Ammi visnaga were used as photosensitizers for dye-sensitized solar cells (DSSCs). Dye Extraction was carried out before and after grinding the plant seeds. TiO2 nanopowder was used as a semiconducting material. The UV-Vis absorption spectra of the extracts of the seeds of Eruca Sativa, Nigella sativa, and Ammi visnaga in ethyl alcohol solution and the current-voltage characteristic curves of the fabricated DSSCs were measured. The energy gaps of the extracted dyes were estimated. The best response was obtained for the DSSC sensitized with Ammi visnaga with an efficiency of 0.107% before grinding the raw material and 0.132% after grinding. The acidic treatment of FTO glass sheets with HNO3 improved the efficiency by 123%, 108% and 105% for the three extracts of Eruca Sativa, Nigella sativa and Ammi visnaga, respectively.
Expectations, Relevance, and Relationships: Striving toward Ideals for Adolescent Literacy Instruction in an Urban Secondary School

Abstract While research on adolescent literacy and urban education have jointly advocated for more evidence of dynamic practices that positively impact youths’ reading development, students in these settings typically receive instruction that focuses more on compliance and skill. In this article, I use a sociocultural perspective to present an ethnographic study of one urban middle and high school whose students were successful on multiple measures of reading. My analysis examines school and classroom practices, teacher and leader beliefs, and student perceptions to examine the relationship across school culture, classroom activity, and students’ reading experiences. Data analysis revealed that through professional routines such as shared planning, frequent dialogue, and the intention to know students personally, Grant Street staff embraced shared ideals about literacy. In turn, the school community applied these ideals to a way of teaching and learning literacy that invoked high expectations, relationships, and a relevant curriculum. Practices that facilitated this approach included independent reading, diverse representation in authors and stories, explicit discussions about social issues and power relationships, tracking individual student progress, and performance-based assessments. This research holds implications for coherent, schoolwide approaches for urban schools striving to support adolescents in literacy.
An Empirical Study into Consumer Acceptance of Dockless Bikes Sharing System Based on TAM

The purpose of this study was to propose an extension model that integrated a technology acceptance model (TAM) with dockless bike-sharing (DLBS) features in order to investigate acceptable behavior when using DLBS. In total, 412 participants from China participated in the study. We used a structural equation model to test our research hypotheses. The research results showed that the extended TAM model provided a more comprehensive understanding of the behavior associated with this context. We observed that perceived usefulness, perceived ease of use, subjective norms, and facilitating conditions played an important role in the intention to use DLBS. Moreover, DLBS features played an important role in perceived usefulness and perceived ease of use. The use intention also had an important effect on use behavior. Surprisingly, the three traits of perceived usefulness did not affect perceived usefulness. As such, this study explored, from a consumer’s perspective, why sharing products are accepted. This study offers significant contributions to the relevant literature of the sharing economy. The research results offer enlightening findings for enterprises, as they encourage consumers to adopt the DLBS.
Utility of Global Longitudinal Strain to Predict Post-Operative Outcomes in Non-Cardiac Surgeries

Background: Pre-operative echocardiography is performed in select groups of patients for cardiac risk stratification. Many parameters, including Left Ventricular Ejection Fraction (LVEF), are assessed during echocardiography. While many studies have cited association between low LVEF and poor operative outcomes, patients with preserved LVEF might have subtle LV dysfunction that may result in adverse outcome. Studies have described the routine use of global longitudinal strain (GLS) as an alternative measure of ventricular function that can detect subtle LV dysfunction. The aim of this study is to determine the value of GLS in predicting post-operative outcomes in non-cardiac surgeries. Methods: This was a retrospective study of patients who had normal LVEF, had undergone subsequent non-cardiac surgery, and had post-operative troponins measured. Outcomes for post-operative myocardial injury, as well as hospital re-admissions and mortality up to 1-year post-surgery were collected. Post-op myocardial injury was defined as a peak Troponin T value of > 0.030 ng/dL or a > 20% increment from baseline. Results: A total of 42 patients were included. 61.9% (n = 26) were males and mean age was 72.3 years. Mortality at 1 year was 14.3% (n = 6) and 28.6% (n = 12) were deemed to have post-operative myocardial injury. 1-year mortality was associated with lower GLS (-18.95% vs. -23.75%, p = 0.001). However, GLS was not associated with post-operative myocardial injury and hospital readmissions. Conclusion: Although GLS values were decreased in non-survivors, our study did not demonstrate the utility of GLS in predicting post-operative events. BRief RePoRT
Morpho-agronomic Characters Under Drought Stress and Genetic Diversity on the Local Landraces of Cowpea [Vigna unguiculata (L.) Walp] From East Nusa Tenggara Province, Indonesia

This study was performed to reveal the morpho-agronomic characters under drought and genetic diversity using SRAP (Sequence-related amplified polymorphism) marker on local landraces of cowpea (Vigna unguiculata (L). Walp) collected from East Nusa Tenggara Province, Indonesia. Data on drought response indexes according to the dry matter production of cowpea plants classified Carolina and Pinu Pahar as drought-sensitive and drought-tolerant cowpea genotypes, respectively. The assessment of the genetic diversity of cowpea genotypes was performed by using 25 SRAP combination primers. A total of 250 bands were produced by which 245 bands (98%) were polymorphic. The value of PIC (Polymorphic Information Content) of SRAP primers in this study varied from the highest value (0.97) to the lowest value (0.71) generated by primer pairs Me4-Em1 and Me3-Em4, respectively, with an average of PIC 0.87. An unweighted pair group method based on arithmetic averages (UPGMA) in this study was performed according to Nei and Li’s similarity index. The analysis of UPGMA and PCoA successfully separated Carolina and Pinu Pahar genotypes into different clusters. The result of the Mantel test showed that there was no significant correlation between the independent morpho-agronomic analysis and SRAP molecular matrix data.
Profiled Horn Antenna with Wideband Capability Targeting Sub-THz Applications

This paper proposes a wideband profiled horn antenna designed using the piecewise biarc Hermite polynomial interpolation and validated experimentally at 55 GHz. The proposed design proves S11 and directivity better than −22 dB and 25.5 dB across the entire band and only needs 3 node points if compared with the well-known spline profiled horn antenna. Our design makes use of an increasing radius and hence does not present non-accessible regions from the aperture, allowing its fabrication with electro erosion techniques especially suitable for millimeter and submillimeter wavelengths.
How Successful Is Transfer Learning for Detecting Anorexia on Social Media?

Anorexia is a mental disorder that involves serious abnormalities in nutritional intake behavior. This behavior leads to significant weight loss, which can lead to severe malnutrition. Specifically, eating disorders exhibit the highest mortality rate of any mental illness. Early identification of anorexia, along with appropriate treatment, improves the speed of recovery in patients. Presently there is a strong and consistent association between social media use and eating concerns. Natural Language Processing, a branch of artificial intelligence, has the potential to contribute towards early anorexia detection in textual data. Currently, there is still a long way to go in the identification of anorexia on social media due to the low number of texts available and in fact, most of these are focused on the treatment of English texts. The main contribution of this paper is the application of transfer learning techniques using Transformer-based models for detecting anorexia in tweets written in Spanish. In particular, we compare the performance between already available multilingual and monolingual models, and we conduct an error analysis to understand the capabilities of these models for Spanish.
Social Listening to Create Bespoke Customer Experiences: Best Practices for Hospitality Operators

Most hospitality operators use social media in their communications as a means to communicate brand image and provide information to customers. Our focus is on a two-way exchange whereby a customer’s social posting is reacted to in real-time by the provider to enhance the customer’s current experience. Using social media in this way is new, and the provider needs to carefully balance privacy and personalization. We describe the process by which the Dorchester Collection Customer Experience (CX) Team approached its social listening program and share lessons to identify best practices for hospitality operators wanting to delight their customers through insights gained from social listening.
Bio-Gasoline and Bio-Kerosene Production by Fractional Distillation of Pyrolysis Bio-Oil Açaí Seeds

The bio-oil obtained by pyrolysis of Açaí (Euterpe oleracea Mart.) seeds at 450 ºC, 1.0 atmosphere, in technical scale, submitted to fractional distillation to produce biofuels-like fractions. The distillation of bio-oil carried out in a laboratory distillation column (Vigreux) of 30 cm. The physical-chemistry properties (density, kinematic viscosity, acid value and refractive index) determined by official methods. The chemical functions present in distillation fractions determined by FT-IR and the chemical composition by GC-MS. The distillation of bio-oil yielded gasoline, light kerosene, and kerosene-like fuel fractions of 16.16, 19.56, and 41.89% (wt.), respectively. All the physical-chemistry properties (density, kinematic viscosity, acid value and refractive index) increase with boiling temperature. The gasoline-like fraction is composed by 64.0% (area.) hydrocarbons and 36.0% (area.) oxygenates, while light kerosene-like fraction by 66.67% (area.) hydrocarbons and 33.33% (area.) oxygenates, and kerosene-like fraction by 19.87% (area.) hydrocarbons and 81.13% (area.) oxygenates.
Validation of SAD PERSONS Scale in Thai Tertiary Context

Objective: To examine the validity of the SAD PERSONS scale (SPS) and item analysis in a Thai tertiary setting. Material and Methods: One hundred and twenty-six inpatients were recruited from a psychiatric ward. Patients were interviewed by a consultant psychiatrist and assessed a variety of suicide risk factors. The SPS was blindly performed by a psychiatric resident. The psychometric properties of SPS was executed by comparing the assessment results. Results: A cut-off point of SPS was at 2/3 in assessing current high suicide risk with the sensitivity 79.0% and specificity 35.0%. While the specificity of cut-off point 4/5 was greater than 90.0%, sensitivity was only 27.0%. Parameters that correlated the high risk of suicide were only depression and statement of future suicide intent. Conclusion: For the purpose of suicide prevention, a sensitivity of screening scale is essential. SPS failed to identify the majority of those requiring high intensity psychological intervention though it shows the high specificity of suicide risk. The instrument should not be applied to screen self-harm patients presenting to general hospitals.
100% human milk diet: an integral part of nutrition management in NICU: PAN India neonatologist’s survey

Background: Exclusive human milk diet (EHMD) benefits preterm infants the most, particularly in neonatal intensive care unit. EHMD is dependent on multiple factors consisting of breastfeeding awareness, availability of pasteurized donor human milk, functioning human milk banks and infrastructure. Neonatal nutritional practice varies considerably in India. The aim of this survey was to understand the implementation and benefits of 100% human milk diet through human milk derived nutritional products in preterm infants from NICU experts’ perspective. Methods: The online survey questionnaire formulated and reviewed by the expert neonatologists was shared with the NICU experts pan India through multiple communication channels and referrals. The survey was constructed on the Google Forms platform, the responses was collected between May 2020 to July 2020. Results: A total of 100 neonatologists responded to the survey from 79 hospitals and 31 cities across India. All the respondents (100%) opined that EHMD is important for preterm infants, 15% opined that EHMD was ensured to all preterm infants, 80% opined that human milk-based fortifier (HMBF) was safe and well tolerated by premature infants, 17% reported that 51-80% of preterm infants experience feed intolerance issues with bovine milk based fortifiers (BMBF), blood urea nitrogen (49%) was chosen as an optimal biochemical parameter for assessing protein utilization in NICU, 93% opined that post discharge nutritional supplementation is required for preterm infants among which 49% respondents opined that HMBF and human milk 70 calorie sachet would be preferable as post discharge nutritional supplementation. Conclusions: EHMD unequivocally offers multiple benefits to preterm infants and hence needs to be included in the NICU protocol, availability of human milk derived nutritional products such as HMBF are termed safe and well tolerated and would aid in implementing EHMD in NICUs. Pasteurized donor human milk is vital for ensuring EHMD, thus access to the same needs to be empowered by strengthening the human milk donation and awareness measures.
Polarization Scramblers to Solve Practical Limitations of Frequency Transfer

Polarization variations in optical fibers are complex and would severely affect the performances of polarization-sensitive signal distribution systems. Owing to advances in experimental techniques and theoretical tools, we observe the effect of polarization variations in the optical fibers and we demonstrate that polarization mode dispersion (PMD) dominates the free-running fiber noise. Ultrahigh correlation, over 99%, is found between the phase fluctuation induced by polarization variation and the temperature fluctuation impacted on the optical fibers. By means of a polarization scrambling technique, the polarization variations in the optical fiber are averaged and the phase perturbations are minimized. It provides a promising solution for suppressing the random disturbances of polarization in the fiber-based optical frequency transfer system and quantum key distribution (QKD) system.
Pharmacogenetics of Direct Oral Anticoagulants

For more than 50 years, oral vitamin K antagonists were the choice of anticoagulant for the long-term treatment and prevention of arterial and venous thromboembolic events. In recent years, four direct oral anticoagulants (DOACs), dabigatran, rivaroxaban, apixaban and edoxaban have been compared with warfarin for thromboembolism prevention. These anticoagulants directly inhibit specific proteins within the coagulation cascade; in contrast, oral vitamin K antagonists inhibit the synthesis of vitamin K-dependent clotting factors. Dabigatran, a direct thrombin inhibitor, and rivaroxaban, apixaban and edoxaban, the factor Xa inhibitors, produce a more predictable, less labile anticoagulant effect. DOACs do not have limitations inherent vitamin K antagonists. DOACs have a predictable pharmacokinetic profile and are free of advers drugs reactions inherent in vitamin K antagonists. However, it is necessary to take into account the pharmacogenetic characteristics of the individual that can affect effectiveness and safety of use of DOACs. The results carried out to the present fundamental and clinical studies of DOACs studies demonstrate an undeniable the influence of genome changes on the pharmacokinetics and pharmacodynamics of DOACs. However, the studies need to be continued. There is a need to plan and conduct larger studies in various ethnic groups with the inclusion of sufficient associative genetic studies of the number of patients in each of the documented groups treatments with well-defined phenotypes.
The Scourge of Aflatoxins in Kenya: A 60-Year Review (1960 to 2020)

Aflatoxins are endemic in Kenya. The 2004 outbreak of acute aflatoxicosis in the country was one of the unprecedented epidemics of human aflatoxin poisoning recorded in mycotoxin history. In this study, an elaborate review was performed to synthesize Kenya’s major findings in relation to aflatoxins, their prevalence, detection, quantification, exposure assessment, prevention, and management in various matrices. Data retrieved indicate that the toxins are primarily biosynthesized by Aspergillus flavus and A. parasiticus, with the eastern part of the country reportedly more aflatoxin-prone. Aflatoxins have been reported in maize and maize products (Busaa, chan’gaa, githeri, irio, muthokoi, uji, and ugali), peanuts and its products, rice, cassava, sorghum, millet, yams, beers, dried fish, animal feeds, dairy and herbal products, and sometimes in tandem with other mycotoxins. The highest total aflatoxin concentration of 58,000 μg/kg has been reported in maize. At least 500 acute human illnesses and 200 deaths due to aflatoxins have been reported. The causes and prevalence of aflatoxins have been grossly ascribed to poor agronomic practices, low education levels, and inadequate statutory regulation and sensitization. Low diet diversity has aggravated exposure to aflatoxins in Kenya because maize as a dietetic staple is aflatoxin-prone. Detection and surveillance are only barely adequate, though some exposure assessments have been conducted. There is a need to widen diet diversity as a measure of reducing exposure due to consumption of aflatoxin-contaminated foods.