Miracle-dz/UniFAR-FTUs huggingface dataset:
ISOPROTERENOL SEBAGAI MODEL INFARK MIOKARDIAL AKUT PADA TIKUS WISTAR

ABSTRACT Decreased oxygen supply and necrosis in the heart muscle cells can lead to acute myocardial infarction. Free radical compounds can lead to oxidative stress in the heart muscle and lead to myocardial infarction. Isoproterenol is a non-selective β-adrenergic agonist can lead to acute myocardial infarction in large doses. The purpose of this study was to validate the model of acute myocardial infarction. This study using male Wistar rats aged two months as the test animal. Male Wistar rats divided into two groups: control group and treatment group. The control group treated with physiological saline and the treatment group treated with isoproterenol 85 mg/kg BW. Isoproterenol administered subcutaneously for two doses with an interval of 24 hours. After 48 hours of the isoproterenol first administration, rat heart rhythm's records with an electrocardiogram (ECG). Furthermore, the rats sacrificed and performed a necropsy. The left ventricle part in the cross section for the macroscopic observation (extensive infarction) with triphenyl tetrazolium chloride (TTC) staining, microscopic observation of infarction with hematoxylin-eosin staining (HE) and immunohistochemical (IHC) to observe the expression of caspase-3. The ECG of isoproterenol group showed elevation in the ST segment. TTC staining shows the expansion of the infarct area. The HE staining showed the typical image of myocardial infarction and the IHC staining results showed an increase in the expression of caspase-3. The results showed that isoproterenol can be use as a model myocardial infarction with parameters of infarction are ECG changes, TTC staining of infarct broad macroscopic image, a histopathological image of heart and apoptosis with the expression of caspase-3. Key words: Isoproterenol, acute myocardial infarction, cardiac histopathology
LambdaY-Calculus With Priorities

The lambdaY-calculus with priorities is a variant of the simply-typed lambda calculus designed for higher-order model-checking. The higher-order model-checking problem asks if a given parity tree automaton accepts the Böhm tree of a given term of the simply-typed lambda calculus with recursion. We show that this problem can be reduced to the same question but for terms of lambdaY-calculus with priorities and visibly parity automata; a subclass of parity automata. The latter question can be answered by evaluating terms in a simple powerset model with least and greatest fixpoints. We prove that the recognizing power of powerset models and visibly parity automata are the same. So, up to conversion to the lambdaY-calculus with priorities, powerset models with least and greatest fixpoints are indeed the right semantic framework for the model-checking problem. The reduction to lambdaY-calculus with priorities is also efficient algorithmically: it gives an algorithm of the same complexity as direct approaches to the higher-order model-checking problem. This indicates that the task of calculating the value of a term in a powerset model is a central algorithmic problem for higher-order model-checking.
ENDOTHELIUM-DEPENDENT EFFECT OF AMARANTHUS CAUDATUS FEEDING ON CONTRACTILE PROPERTIES OF THORACIC AORTA FROM DIABETIC RATS

is some evidence of antidiabetic and vascular function-improving potential of Amaranthus caudatus (AC). Endothelium-dependent effects of oral administration of AC for 8 weeks on contractile and relaxatory response of thoracic aorta from diabetic rats were investigated. Materials and Methods: Wistar rats were divided into control, AC-treated control, diabetic, AC-treated diabetic, and glibenclamide-treated diabetic groups. For induction of type 1 diabetes, streptozotocin at a dose of 60 mg/kg (i.p) was injected. Treated groups received AC-mixed pelleted food at a weight ratio of 6.25%. Body weight and serum glucose level was measured before the study and after 4 and 8 weeks. At the end of study, contractile reactivity of thoracic aortic rings to KCl and phenylephrine and relaxatory response to acetylcholine and sodium nitroprusside was determined using isolated tissue setup. Results: Serum glucose level significantly decreased in AS-treated diabetic group (P<0.05) versus untreated diabetics. In addition, endothelium-intact AC-treated diabetic group showed a significantly lower contraction to KCl and phenylephrine (P<0.01) as compared to diabetic group and endothelium removal abolished this response. Meanwhile, relaxation response of endothelium-intact rings to acetylcholine was significantly higher in AC-treated diabetic group as compared to diabetics (p<0.01). In addition, there were no significant changes amongst the groups regarding relaxatory response to sodium nitroprusside. Conclusion: Chronic oral administration of AC through affecting endothelial-related agents could decrease contractile response and enhance relaxatory response in aortic tissue of diabetic rat and this may be beneficial in prevention of long-term vascular complications of diabetes.
Encapsulation Process and Materials Evaluation for E-Textile Gas Sensor

The degree of pollution in the environment increases because of the vehicular emissions such as carbon monoxide (CO) and nitrogen dioxide (NO2) gases. To minimize the exposure levels, it is necessary for individuals to be able to determine for themselves the pollution levels of the environments they are in so that they can take the necessary precautions. Textile-based gas sensors are an emerging solution and this paper furthers the concept by investigating a novel method for encapsulating gas sensors in textiles. While encapsulation is required to improve the durability and lifetime of the sensors, it essential for their operation that the encapsulants do not reduce the sensitivity of the gas sensor. This paper investigates the selectivity of two different flexible and breathable thermoplastic encapsulants (Platilon®U and Zitex G-104) for sensing carbon monoxide by observing the sensor response with and without the encapsulants. Results show that while the encapsulants both enable the sensor to still function, Platilon®U reduces the sensor sensitivity, whereas Zitex G-104 has very little effect.
Soft-Error Tolerance Depending on Supply Voltage by Heavy Ions on Radiation-Hardened Flip Flops in a 65 nm Bulk Process

We evaluated soft-error tolerance by heavy ions on several types of flip flops (FFs) called transmission-gate FF (TGFF), Dual Interlocked Storage Cell FF (DICEFF), Bistable Cross-coupled Dual Modular Redundancy FF (BCDMRFF) and BCDMRFF with Set and Reset (BCDMRFFSR) in a 65 nm bulk process. Radiation-hardened FFs are stronger against soft errors than a standard TGFF by two or three order of magnitude. DICEFF has higher soft-error tolerance than BCDMRFF by low-LET heavy ions less than 40 MeV-cm2/mg, while BCDMRFF is stronger against soft error than DICEFF by high-LET ions over 40 MeV-cm2/mg. DICEFF becomes weaker by lowering supply voltage, while BCDMRFF has higher soft-error tolerance than DICEFF when supply voltages is less than 1.0 V.
Improving the Precision of Indoor Positioning Systems

Over the last few years, the demand for indoor positioning systems has been increasing at a very rapid pace. This dynamic has been fueled by interest sparking from a multitude of opportunities for ubiquitous connectivity spearheaded by the Internet of Things movement and it has led to the development of numerous devices, systems and applications. The ability to sense data, gather and process information, decide intelligently on how to affect resources, control devices, systems and people is at the heart of such a movement. Industrial, commercial, ludic and scientific spaces want to direct workers, users and resources to certain items or tasks for reasons of security, efficiency, profit, etc. In order to answer this growing need, low-cost, higher accuracy indoor positioning techniques are required. The goal of this thesis consists in assessing currently existing technologies for this task, compare them, propose improvements to their accuracy and provide recommendations regarding their usage. Serving both as a testbed and as a demonstration facility, an indoor positioning system which addresses these requirement has been developed. Clearly it would not be possible to analyze all technologies available that could be used for this task and therefore options had to be made. This is why in this thesis we concentrated on low-cost low-energy Bluetooth solutions. Therefore, prior to system implementation, an analysis of the Bluetooth low energy received signal strength was done over time and distance. In addition, we evaluated the signal coexistence with Wi-Fi, with multiple Bluetooth beacons broadcasting at the same time and in a path experiment. The experimental/demonstration system was implemented on the first floor of INESC-ID in Lisbon, Portugal. An Android application was developed that is capable of calculating and displaying the users position and based on this information to present to the user suggested items previously chosen by the system administrator, via notifications. The position estimation was improved by using the fingerprint method and the weighted k-nearest neighbour comparison method between the online received signal strength measurements and the offline measurements database. A Kalman filter was used to track the users position and thus further improve accuracy. A static accuracy of less than 3m was achieved 95% of the time with a mean error of approximately 1.5m, using 1 fingerprint per 2.5m and 1 beacon deployed per 5m. The system exhibits a position error of approximately 5.5m when using a reduced fingerprint density (1 fingerprint per 10m) while a reduced density of beacons (1 beacon per 20m) enables a mean accuracy of 1.8m. Kalman filter position tracking improved the correlation of the users positions over time.
A Guide to Drug Therapy in Patients with Enteral Feeding Tubes: Dosage Form Selection and Administration Methods

Drug therapy may be complicated in hospitalized patients receiving nutrition via enteral feeding tubes. Dosage form selection and appropriate administration methods are crucial in patients with feeding tubes. Although hospitalized patients receive nutritional support through various routes, oral nutrition is preferred. Enteral or parenteral nutrition may be used if oral intake is inadequate or inadvisable. Patients with functional gastrointestinal tracts usually receive enteral nutrition. Administering oral medications through the enteral feeding tube can lead to complications like tube clogging or decreased drug activity. However, drug therapy need not be compromised in patients receiving enteral nutrition. Careful selection and preparation of dosage forms reduces the complications of medication administration. Flushing the feeding tube and screening for drug incompatibilities decreases the incidence of tube clogging and replacement.
An Unique Approach to Element Management and Secure Cloud Storage Backup for Sensitive Data

with dynamic trends and new developments in hardware and software, and the need to manage them efficiently, designing an Element Management System (EMS) for effective management of Network Element’s (NE) is a challenging task. Small and medium businesses may not have the required skills or resources to manage their EMS. Large businesses may also want to use EMS services from skilled vendors. With the emergence of cloud computing technology, EMS can be provided as a service, i.e., SaaS (software as service) to different customers. As promising as it is, this paradigm also brings forth many new challenges for data security and access control when users outsource confidential and old management data for sharing on public cloud ,i.e., which are not within the same trusted domain. In this proposed scheme, the EMS is provided as a service to different sites of the organization using a private cloud. Sensitive data is stored in the public cloud which comprises of the current configuration of the complete private cloud, important disaster recovery data and management data. This would provide a confidential, secure backup of EMS. This would be useful in the case of natural calamities (tsunami, tornado, earth quake, etc.), terrorist attacks and any other disaster that strikes the private cloud. The clients/data owners, who require management data, can access the data from the public cloud. While accessing data from the public cloud, integrity and confidentiality of the data is preserved by using 2 techniques, namely Attribute Based Encryption (ABE) and Proxy Re-Encryption (PRE).
Comment on Justin van der Sluis and C. Mirjam van Praag: Is Economic returns to education for entrepre- neurs: The development of a neglected child in the family of economics of education?

Entrepreneurship as an academic field can be characterized as being phenomenon driven and multi-disciplinary. Consequently, theories and methods established in other disciplines such as economics, sociology and psychology are frequently applied in entrepreneurship research. In order to make advancements and gain legitimacy, it is important that this research utilizes the latest theoretical insights and methodological developments in these disciplines. In their article, van der Sluis and van Praag adhere to these principles by using novel methodological insights applying them to entrepreneurship. Labor economists have since long established that it is difficult to directly estimate how education affects economic returns, since unobserved abilities are likely to affect both education and income so that those with greater abilities choose both longer educations and perform better at work, which gives them higher incomes. As a result, simply regressing income on education will lead to biased results. As van der Sluis and van Praag rightly note, these insights have not yet made their way into entrepreneurship research, thereby representing an area where entrepreneurship research has, so far, failed to keep up with methodological advancements made in the other disciplines. In their sophisticated and careful analyses of US and Dutch data, van der Sluis and van Praag show that because of the failure to acknowledge such relationships, previous research has underestimated the returns to education for the self-employed. In fact, they suggest that, if anything, the returns to education are higher among the self-employed than among the employed. Using similar logic and methodology, they then argue that capital constraints are, to some extent, dependent upon education, so that those with longer education find it easier to
Chronic renal disease in elder people

Founding principle: chronic renal insufficiency is defined as the kidney structural or functional damage, evidenced by markers of damage (urine, blood or images) for a period of three months or more. Between 8 and 10 % of the general adult population has some renal damage. Objective: to know the incidence and prevalence of the chronic renal disease in elder people, in the Teaching Clinic Surgical Hospital Comandante Faustino Perez Hernandez. Methods: a retrospective descriptive longitudinal study was carried out. The sample was formed by 274 patients fulfilling the inclusion criteria. The used variables were: age, sex, skin color, weight, personal pathological antecedents, entering cause, chronic renal disease s progression factors, toxic habits and creatinine value. For organizing the obtained indicators we applied the descriptive statistic method, analyzing the information through frequency distribution tables, graphics resuming measures as average and mode for the quantitative variables, and absolute numbers and percentage for the qualitative variables. Results: high nosocomial prevalence of the chronic renal disease in elder people, more frequent in the female sex and white people; coexistence of many risk factors, predominating arterial hypertension, cardiopathies, diabetes mellitus, age and smoking. The most frequently found progression factors were de decompensated arterial hypertension, renal hypoperfusion and sepsis. Conclusions:there is high nosocomial prevalence of the chronic renal disease in elder people.
Identification of REST regulated genes in prostate cancer via high-throughput technologies

Prostate cancer (PCa) is one of the most commonly diagnosed cancers in the world: males have 17% risk of developing PCa during lifetime. Androgen deprivation therapy (ADT) has been the leading form of PCa therapy [1]. Unfortunately, the effectiveness of this treatment is usually temporary, with a subpopulation of cells surviving. Growing evidence indicates that neuroendocrine differentiation (NED) occurs in 30-100% of disease recurrence after ADT [2, 3]. However, the mechanism is still poorly understood. Repressor element-1 silencing transcription factor (REST) is responsible for restricting neuronal gene expression to the nervous system. REST was recently shown to be absent in various types of cancer. Blockade of REST function in human LNCaP cells is found to cause NED [4], indicating REST may be one of important determinants of neuroendocrine prostate cancer (NEPC). The aim of this study is to investigate the potential role of REST in PCa progression. We combined state-of-the-art sequencing technologies and bioinformatics with patient-derived next-generation models of PCa to deal with this problem. An integrated data analysis of RNA-seq on mouse xenograft model and expression microarray with RNA interference on human LNCaP cells was performed to identify potential REST targets. Experimentally, we validated most likely targets by QRT-PCR of LNCaP mRNA. In addition, we also estimated the clinical significance of the targets using public datasets. Our results help to elucidate the mechanism that drives development of androgen independent and aggressive NEPC after castration. Furthermore, it could provide a new prognosis factor for PCa and also provide a new target for the PCa treatment.
Current-Voltage and Capacitive Behavior of Zinc Oxide:Poly(methyl methacrylate) composite films

In the present investigations, simple solution casting technique has been employed for the preparation of novel composite films of Zinc Oxide (ZnO) and Poly(methyl methacrylate) (PMMA). Different filler concentrations of ZnO have been prepared to study the capacitive behavior of the composite film at room temperature. The dielectric permittivity (ε) was measured as a function of frequency at different voltages (0, 2 and 5 V) over the range of 100 Hz – 10 MHz at room temperature. The dielectric permittivity of the composite films increases as enhanced the filler concentrations of ZnO in PMMA. The capacitance vs. frequency characteristics of the composite films reveals that the value of capacitance increases ~ 2 – 5 times from higher frequency region to lower region with increase in filler concentration of ZnO at room temperature. The I-V characteristics of the composite films were also investigated at room temperature.
Endogenous Leverage and Default in the Laboratory

We study default and endogenous leverage in the laboratory. To this purpose, we develop a general equilibrium model of collateralized borrowing amenable to laboratory implementation and gather experimental data. In the model, leverage is endogenous: agents choose how much to borrow using a risky asset as collateral, and there are no ad hoc collateral constraints. When the risky asset is financial? namely, its payoff does not depend on ownership (such as a bond)? collateral requirements are high and there is no default. In contrast, when the risky asset is nonfinancial? namely, its payoff depends on ownership (such as a firm)? collateral requirements are lower and default occurs. The experimental outcomes are in line with the theory's main predictions. The type of collateral, whether financial or not, matters. Default rates and loss from default are higher when the risky asset is nonfinancial, stemming from laxer collateral requirements. Default rates and collateral requirements move closer to the theoretical predictions as the experiment progresses.
Decision Support System Development to Groundwater Management and Aquifer Vulnerability Assessment: Hydrogeological Information System of Monastir (HISM)

In Tunisia and particularly in Monastir region, groundwater constitutes the main source of water supply systems. A lot of problems are facing the water management authorities. In fact, the Moknine coastal aquifer highlights several qualitative and quantitative anomalies due to the irrigated perimeters extension (Teboulba, Bekalta), releases of harmful products from the textile industry (Ksar Hellal and Moknine), intense overexploitation and seawater intrusion. Thus, for groundwater resources management, a Decision Support System (DSS) is developed for the Monastir region. This Decision Support System (DSS) brings together, on a digital support, the data descriptive and graphical component for groundwater management. It is a hydrogeological relational database joined with a Hydrogeological Information System for the Monastir region (HISM) which enables fast and effective processing of large volumes of spatial data from multiple sources. The implementation of the Hydrogeological Information System is assured using Object-Oriented Programming (OOP). The “Unified Modeling Language” (UML) is an Object-Oriented Design (OOD) methodology which is choiced for data modeling. The application interfaces have been developed in Visual Basic (VB.net) within the Integrated Development Environment (IDE) from Microsoft Visual Studio. “DotSpatial” library integrated is used to manage the geographic information layers. The HISM contains thematic layers acquired through the vectorization of 22 topographic and geologic maps (1/50,000 and 1/25,000) and the input of descriptive data from water well and pollution sources from field and laboratory studies. The HISM has a great management capacity; it ensures the conversion from the geographic coordinates to the planimetric coordinates. It allows adding, modifying, deleting and editing data (Rainfall, piezometric and geochemical). It also ensures the storage and editing of the digitized and/or generated cartographic database. This DSS was applied to the superficial coastal aquifer system of Moknine to define a conceptual model of groundwater functioning and assessment vulnerability to seawater intrusion.
Voltage Stability Assessment Using the Concept of GVSM

To assessment of voltage stability of multi bus power system, the main requirement is equivalent twobus network models, which is fulfilled by lumping all the series impedances and shunt admittances of transmission lines within a series equivalent impedance. This paper shows the development of an equivalent pi network model using a new technology or methodology called generalized global voltage stability margin (GVSM). This is used to assess the overall voltage stability status of the system accurately. Simulation results for IEEE 14 Test bus system, IEEE 30 Test bus system , IEEE 118 Test bus system are establish that the piequivalent model obtained by the proposed method is highly accurate for assessing voltage stability of any power system at any operating point in a better way as compared to series equivalent model.