Miracle-dz/UniFAR-FTUs huggingface dataset:
Bi-Directional Theta Modulation between the Septo-Hippocampal System and the Mammillary Area in Free-Moving Rats

Hippocampal (HPC) theta oscillations have long been linked to various functions of the brain. Many cortical and subcortical areas that also exhibit theta oscillations have been linked to functional circuits with the hippocampus on the basis of coupled activities at theta frequencies. We examine, in freely moving rats, the characteristics of diencephalic theta local field potentials (LFPs) recorded in the supramammillary/mammillary (SuM/MM) areas that are bi-directionally connected to the HPC through the septal complex. Using partial directed coherence (PDC), we find support for previous suggestions that SuM modulates HPC theta at higher frequencies. We find weak separation of SuM and MM by dominant theta frequency recorded locally. Contrary to oscillatory cell activities under anesthesia where SuM is insensitive, but MM is sensitive to medial septal (MS) inactivation, theta LFPs persisted and became indistinguishable after MS-inactivation. However, MS-inactivation attenuated SuM/MM theta power, while increasing the frequency of SuM/MM theta. MS-inactivation also reduced root mean squared power in both HPC and SuM/MM equally, but reduced theta power differentially in the time domain. We provide converging evidence that SuM is preferentially involved in coding HPC theta at higher frequencies, and that the MS-HPC circuit normally imposes a frequency-limiting modulation over the SuM/MM area as suggested by cell-based recordings in anesthetized animals. In addition, we provide evidence that the postulated SuM-MS-HPC-MM circuit is under complex bi-directional control, rather than SuM and MM having roles as unidirectional relays in the network.
Combining source transformation and operator overloading techniques to compute derivatives for MATLAB programs

Derivatives of mathematical functions play a key role in various areas of numerical and technical computing. Many of these computations are done in MATLAB, a popular environment for technical computing providing engineers and scientists with capabilities for mathematical computing, analysis, visualization, and algorithmic development. For functions written in the MATLAB language, a novel software tool is proposed to automatically transform a given MATLAB program into another MATLAB program capable of computing not only the original function but also user-specified derivatives of that function. That is, a program transformation known as automatic differentiation is performed to change the semantics of the program in a fashion based on the chain rule of differential calculus. The crucial ingredient of the tool is a combination of source-to-source transformation and operator overloading. The overall design of the tool is described and numerical experiments are reported demonstrating the efficiency of the resulting code for a sample problem.
Is the Mobile Phone a Disruptive Technology? A Partial Review of Evidence from Developing Countries

The authors of this chapter provide an inter-disciplinary review of studies on economic impacts of mobile telephony in developing countries, giving particular attention to the disruptive potential of the technology and its associated social practices. Four major areas of impact are identified: the emergence of a mobile phone economy around retail and service provision, including mobile banking; a significant reduction in search costs with profound impacts on market efficiency and, possibly, welfare distribution; changes in the formation and maintenance of trusting relationships between market actors as face-to-face contact is replaced with remote communication; and facilitated organisation and cooperation within and among firms, as well as changing credit procurement practices. While the mobile phone has been hailed for its transformative power, the authors tentatively conclude that its impact in most areas is not primarily disrupting, but rather amplifying existing structures.
The relationship between hand strength and the forces used to access containers by well elderly persons.

OBJECTIVE This study extended previous work of Rice, Leonard, and Carter [AJOT, 52(8), 621-626] and examined the relationship between grip and pinch strengths and the forces produced while accessing common household containers in healthy, elderly persons. METHOD Forty-two women and 9 men 60 years of age and older were assigned randomly to one of four order groups in a counterbalanced, repeated-measures design. Grip strength was measured via a dynamometer and pinch strength via a pinch meter. The forces required to access six common household containers were measured with force sensing resistors applied to each container. Data analysis included Pearson product-moment correlations between the dependent variables of grip and pinch strength and force produced on the containers. Analyses of variance were used to determine differences by gender on the dependent measures and order of presentation of containers. RESULTS A fair relationship (r = .31 to .44) was found between grip and pinch strength and the ability to open three containers. Little or no relationship was found between grip and pinch strength and the ability to open the remaining three containers (r = -.03 to .25). Significant gender differences existed on overall strength and the force used to access two of the six containers. No order effects were found. CONCLUSIONS Strong relationships did not exist between the grip and pinch strength and the amount of force the elderly participants used to open the containers, which is similar to what Rice et al. found for younger persons. The participants appeared to use a greater proportion of their available strength when accessing the containers than did their younger counterparts previously studied. Further research is needed to determine at what level of weakness one would expect to see performance deficits in common daily occupations.
Aging of Retrieved Zirconia Femoral Heads

Yttria-stabilized tetragonal zirconia may undergo extensive transformation to the monoclinic phase under mechanical and/or hydrothermal stress, with degradation of mechanical and tribologic properties. We hypothesized progressive phase transformation of zirconia in service in vivo is directly related to the time of implantation and to patient-related factors. The subsequent decrease in fracture toughness and increase in surface roughness and wear are related to the increased monoclinic content. We performed a study on 47 yttria-stabilized tetragonal zirconia femoral heads retrieved from failed total hip arthroplasties after 2 to 10 years implantation. Age, weight, and activity of the patients were retrieved from clinical records. Monoclinic content, fracture toughness, surface roughness, and wear were measured. Strong correlations were found between monoclinic content in the weightbearing surface and time of implantation (r = 0.97) and between increase in monoclinic content and decrease in fracture toughness (r = −0.92), increase in surface roughness (r = 0.88), and increase in surface wear (r = 0.89). No correlation was observed between the increase in monoclinic content and the age, weight, or activity of the patients. Aging of zirconia in vivo is then a function of time in service, and the loss of surface properties is caused by the corresponding increase in monoclinic content. Level of Evidence: Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence.
Case report--A forgotten dermatological disease.

Arthroplasty is used to relieve pain associated with degenerative or inflammatory joint disease, some post-traumatic joint problems, and avascular necrosis. Avascular necrosis, inflammatory and post-traumatic problems are seen on a regular basis in areas of high HIV seroprevalence. Degenerative arthritis is rare in younger HIV patients, however. Historically the only group of HIV patients in which arthroplasty has been common is that which received contaminated factor VIII transfusions in the 1980's. Haemophiliacs get a haemophilic arthropathy from repeated bleeds into joints and so is an additional complication. Much of the previous literature on this topic has focused on haemophiliac patients. This review examines the success of arthroplasty in HIV positive patients, with an emphasis on non-haemophiliac patients. We conclude that arthroplasty can be a safe procedure for HIV positive individuals if the surgery is carried out in good conditions, and early results are encouraging.
The computational cutoff rate of channels having memory

A random coding bound is derived for block coded transmission over channels characterized by a deterministic finite-memory part followed by the addition of white Gaussian noise. (Intersymbol interference channels are a special case.) According m this bound, a "product-measure cutoff rate" can be defined quite naturally for such a class of channels.
Impact basin relaxation as a probe for the thermal history of Pluto

We investigate viscoelastic impact basin relaxation on Pluto for a variety of thermal evolution scenarios encompassing both convective and conductive ice shells. Basins smaller than 200 km in diameter do not relax appreciably, while relaxation fractions can be up to ∼60% for large impact basins. The main control on basin relaxation is the amount of radiogenic heat produced in the rocky core; our results are insensitive to the formation time of the basin, the ice reference viscosity adopted, and the presence/absence of a subsurface ocean. Other volatiles, such as CO2 or NH3, if present in the ice shell in sufficient quantities could increase the predicted relaxation fraction of basins. Relaxation causes extensional stresses interior to the basin; the orientation of the resulting tectonic features is controlled by the effective elastic thickness beneath the basin. Future observations of the relaxation states and tectonics of impact basins are therefore likely to provide a key constraint on Pluto's thermal history.
Playing linear number board games—but not circular ones—improves low-income preschoolers’ numerical understanding.

A theoretical analysis of the development of numerical representations indicated that playing linear number board games should enhance preschoolers’ numerical knowledge and ability to acquire new numerical knowledge. The effect on knowledge of numerical magnitudes was predicted to be larger when the game was played with a linear board than with a circular board because of a more direct mapping between the linear board and the desired mental representation. As predicted, playing the linear board game for roughly 1 hr increased low-income preschoolers’ proficiency on the 2 tasks that directly measured understanding of numerical magnitudes—numerical magnitude comparison and number line estimation—more than playing the game with a circular board or engaging in other numerical activities. Also as predicted, children who had played the linear number board game generated more correct answers and better quality errors in response to subsequent training on arithmetic problems, a task hypothesized to be influenced by knowledge of numerical magnitudes. Thus, playing linear number board games not only increases preschoolers’ numerical knowledge but also helps them learn from future numerical experiences.
Sovereign Bonds and Socially Responsible

This article investigates how the mean- variance efficient frontier defined by sovereign bonds of 20 developed countries is affected by the consideration of socially responsible indicators for countries in investment decision-making. For a global rating of socially respon- sible performances, we show that it is possible to build portfolios with an increased average rating without sig- nificantly harming the risk/ return relationship. This result differs when considering sub-ratings related to the envi- ronment, social concerns and public governance. The results are good news for responsible investors and suggest that socially responsible portfolios of sovereign bonds can be built without a significant loss of mean-variance effi- ciency.
Identification and methionine analog tolerance of environmental bacterial isolates selected on methionine analog containing medium

Methionine is the first limiting amino acid in poultry feed. Currently, methionine supplement is synthesized from an expensive chemical process requiring hazardous chemicals. Therefore, the objectives of this study were isolation of methionine producing bacteria from environmental samples and quantification of methionine production in these isolated bacteria. MCGC medium was selected as the isolation medium for methionine-producing bacteria by using Corynebacterium glutamicum ATCC13032 and Escherichia coli ATCC23798 as the positive and negative controls, respectively. Thirty-nine bacterial strains were obtained from environmental samples. Only strains A121, A122, A151 and A181 were able to tolerate up to 0.1% (w/v) of ethionine or norleucine. These isolated strains were identified by sequencing small subunit rRNA genes. The results revealed that bacterial strains A121, A122, A151and A181 were Klebsiella species, Acinetobacter baumannii, A. baumannii and Pseudomonas aeruginosa, respectively. When methionine production in strains A121 and A181 was quantitated, strains A121 and A181 generated methionine up to 31.1 and 124.6 μg/ml, respectively.
Biaxial strain in suspended graphene membranes for piezoresistive sensing

Pressure sensors based on suspended graphene membranes have shown extraordinary sensitivity for uniaxial strains, which originates from graphene's unique electrical and mechanical properties and thinness [1]. This work compares through both theory and experiment the effect of cavity shape and size on the sensitivity of piezoresistive pressure sensors based on suspended graphene membranes. Further, the paper analyzes the effect of both biaxial and uniaxial strain on the membranes. Previous studies examined uniaxial strain through the fabrication of long, rectangular cavities. The present work uses circular cavities of varying sizes in order to obtain data from biaxially strained graphene membranes.
State Health Insurance Mandates and Labor Market Outcomes

We re-visit the relationship between private health insurance mandates, access to employer-sponsored health insurance, and labor market outcomes using the National Longitudinal Survey of Youth 1979. We model employer-sponsored health insurance access and labor market outcomes across the lifecycle as a function of the number of high cost mandates in place at labor market entrance. We find no evidence that high cost state health insurance mandates discourage employers from offering insurance to employees. Employers adjust wages and labor demand to offset mandate costs. Mandate effects are persistent but not permanent. We document heterogeneity across worker-types.
New implementation of the correlation function of the PN code for application in automotive radars

This paper presents a new method for implementing the shifting of the PN code to calculate the correlation function which is used to measure the target range in the spread spectrum automotive radar. The new method results In higher resolution without increasing the chip rate of the PN code (which necessitate increasing the bandwidth). This new method has the facility of variable resolution without increasing the complexity of the system.
User-Managed Access (UMA) Profile of OAuth 2.0

User-Managed Access (UMA) is a profile of OAuth 2.0. UMA defines how resource owners can control protected-resource access by clients operated by arbitrary requesting parties, where the resources reside on any number of resource servers, and where a centralized authorization server governs access based on resource owner policies.
Cellular Mechanisms for Human Procollagenase-3 (MMP-13) Activation

Gelatinase A and membrane-type metalloproteinase (MT1-MMP) were able to process human procollagenase-3 (Mr 60,000) to the fully active enzyme (Tyr85 N terminus; Mr 48,000). MT1-MMP activated procollagenase-3 via a Mr 56,000 intermediate (Ile36 N terminus) to 48,000 which was the result of the cleavage of the Glu84-Tyr85 peptide bond. We have established that the activation rate of procollagenase-3 by MT1-MMP was enhanced in the presence of progelatinase A, thereby demonstrating a unique new activation cascade consisting of three members of the matrix metalloproteinase family. In addition, procollagenase-3 can be activated by plasmin, which cleaved the Lys38-Glu39 and Arg76-Cys77 peptide bonds in the propeptide domain. Autoproteolysis then resulted in the release of the rest of the propeptide domain generating Tyr85 N-terminal active collagenase-3. However, plasmin cleaved the C-terminal domain of collagenase-3 which results in the loss of its collagenolytic activity. Concanavalin A-stimulated fibroblasts expressing MT1-MMP and fibroblast-derived plasma membranes were able to process human procollagenase-3 via a Mr 56,000 intermediate form to the final Mr 48,000 active enzyme which, by analogy with progelatinase A activation, may represent a model system for in vivo activation. Inhibition experiments using tissue inhibitor of metalloproteinases, plasminogen activator inhibitor-2, or aprotinin demonstrated that activation in the cellular model system was due to MT1-MMP/gelatinase A and excluded the participation of serine proteinases such as plasmin during procollagenase-3 activation. We have established that progelatinase A can considerably potentiate the activation rate of procollagenase-3 by crude plasma membrane preparations from concanavalin A-stimulated fibroblasts, thus confirming our results using purified progelatinase A and MT1-MMP. This new activation cascade may be significant in human breast cancer pathology, where all three enzymes have been implicated as playing important roles.
A high energy saving interface system using a matrix converter between a power grid and an engine generator for bio diesel fuel

This paper discusses an interface power converter between a power grid and an engine generator. A matrix converter, which is one of the AC/AC direct converters, can achieve high efficiency without large energy storages. Therefore, the volume of the converter becomes smaller and the reliability of the interface system is improved due to no use of electrolytic capacitor. This paper discusses the control strategy of a matrix converter for the power grid interconnection. In addition, the performances are demonstrated by simulation and experiments with a 1.5-kW prototype. The proposed control method is confirmed in the simulation and experimental results. Furthermore, the maximum efficiency of 96.8 % is obtained in the experiment. Total loss of the power converter is approximately half of the conventional system that is using a Back-to-Back converter.
Dynamic Evaluation of Indian Commercial Banking Sector: A Bank-Level Growth Frontier Approach

The authors investigate the Indian commercial banking sector in the dynamic framework. Growth frontiers are derived with the help of Data Envelopment Analysis (DEA) to identify growth-efficient and growth-inefficient banks. The growth theories demand a steady-state growth path for each sector of the economy; on the other hand, the resource-based theory assumes firm-specific growth rates. The analysis shows dismal performance by domestic banks, both public sector and private; most of these domestic banks are growth-inefficient both in the short-run and in the long-run. The short-run as well as long-run findings strongly support the role of learning by doing as an engine to augment growth for all categories of banks. The analysis also exposes that the resource-based view of firm that generates rent generating competitive advantage ultimately drives both the managerial strategies and the performance of the Indian banking sector.
Hospital response to DRG refinements: the impact of multiple reimbursement incentives on inpatient length of stay.

Recent research has warned that the introduction of Diagnosis Related Groups (DRGs) based on hospital treatment decisions will lead to an increase in the rate of marginal procedures and to a resumption of high medical expenditure growth rates. This paper explores the often contradictory effects of the multiple reimbursement incentives created by refinements to the Prospective Payment System (PPS) (principally, the introduction of procedure-based DRGs) on hospital resource allocation. Three effects are examined in the paper: (i) the change in primary or payment-related procedures owing to marginal reimbursement incentives; (ii) the change in secondary or non-payment-related services owing to average price incentives; and (iii) the change in average severity of both medical and surgical admissions. The model suggests that the anticipated positive effect of marginal reimbursement incentives on overall hospital resource use may be offset by several factors, most notably the lower average payment incentives of non-procedural DRGs.
pH Dependence of the Inwardly Rectifying Potassium Channel, Kir5.1, and Localization in Renal Tubular Epithelia*

The physiological role of the inwardly rectifying potassium channel, Kir5.1, is poorly understood, as is the molecular identity of many renal potassium channels. In this study we have used Kir5.1-specific antibodies to reveal abundant expression of Kir5.1 in renal tubular epithelial cells, where Kir4.1 is also expressed. Moreover, we also show that Kir5.1/Kir4.1 heteromeric channel activity is extremely sensitive to inhibition by intracellular acidification and that this novel property is conferred predominantly by the Kir5.1 subunit. These findings suggest that Kir5.1/Kir4.1 heteromeric channels are likely to exist in vivo and implicate an important and novel functional role for the Kir5.1 subunit.
Probiotics and oral health effects in children.

BACKGROUND Probiotics are living micro-organisms added to food which beneficially affect the host by improving its intestinal microbial balance. OBJECTIVE This paper aims to present a general background on probiotics and its health effects in children, and to examine the evidence for oral colonization and the possible impact on oral health in children and young adults. METHODS For delivery and general health effects, recent systematic reviews, meta-analyses, and other relevant papers were used. Concerning oral installation and oral effects, a broad search for publications in English was conducted through February 2007 in PubMed. Studies describing an installation or intervention trial in humans with a controlled design and an oral endpoint measure were considered. Fourteen papers with dental focus were identified, of which two were narrative reviews. RESULTS Only one study of dental interest was conducted in children. Four papers dealt with oral installation of probiotic bacteria, and although detectable levels were found in saliva shortly after intake, the studies failed to demonstrate a long-term installation. Seven papers evaluated the effect of lactobacilli- or bifidobacteria-derived probiotics on the salivary levels of caries-associated bacteria in placebo-controlled designs. All but one reported a hampering effect on mutans streptococci and/or yeast. The single study carried out in early childhood reported a significant caries reduction in 3- to 4-year-old children after 7 months of daily consumption of probiotic milk. CONCLUSION Bacteriotheraphy in the form of probiotic bacteria with an inhibitory effect on oral pathogens is a promising concept, especially in childhood, but this may not necessarily lead to improved oral health. Further placebo controlled trials that assess carefully selected and defined probiotic strains using standardized outcomes are needed before any clinical recommendations can be made.