Miracle-dz/UniFAR-FTUs huggingface dataset:
Phosphodiesterase-5 Inhibitor Sildenafil Preconditions Adult Cardiac Myocytes against Necrosis and Apoptosis

We investigated the effect of sildenafil in protection against necrosis or apoptosis in cardiomyocytes. Adult mouse ventricular myocytes were treated with sildenafil (1 or 10 μm) for 1 h before 40 min of simulated ischemia (SI). Necrosis was determined by trypan blue exclusion and lactate dehydrogenase release following SI alone or plus 1 or 18 h of reoxygenation (RO). Apoptosis was assessed by terminal deoxynucleotidyl transferase-mediated nick end labeling assay and mitochondrial membrane potential measured using a fluorescent probe 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolyl-carbocyanine iodide (JC-1). Sildenafil reduced necrosis as indicated by decrease in trypan blue-positive myocytes and leakage of lactate dehydrogenase compared with untreated cells after either SI or SI-RO. The number of terminal deoxynucleotidyl transferase-mediated nick end labeling-positive myocytes or loss of JC-1 fluorescence following SI and 18 h of RO was attenuated in the sildenafil-treated group with concomitant inhibition of caspase 3 activity. An early increase in Bcl-2 to Bax ratio with sildenafil treatment was also observed in myocytes after SI-RO. The increase of Bcl-2 expression by sildenafil was inhibited by nitric-oxide synthase (NOS) inhibitor, l-nitro-amino-methyl-ester. The drug also enhanced mRNA and protein content of inducible NOS (iNOS) and endothelial NOS (eNOS) in the myocytes. Sildenafil-induced protection against necrosis and apoptosis was absent in the myocytes derived from iNOS knock-out mice and was attenuated in eNOS knock-out myocytes. The up-regulation of Bcl-2 expression by sildenafil was also absent in iNOS-deficient myocytes. Reverse transcription-PCR, Western blots, and immunohistochemical assay confirmed the expression of phosphodiesterase-5 in mouse cardiomyocytes. These data provide strong evidence for a direct protective effect of sildenafil against necrosis and apoptosis through NO signaling pathway. The results may have possible therapeutic potential in preventing myocyte cell death following ischemia/reperfusion.
Pertinence Du Goodwill Acquis Au Regard Des Resultats Residuels Nets Et Additionnels : Relation Theorique Et Etude Empirique Sur Le Marche Francais

In this paper, we investigate whether the acquired goodwill is generating future earnings in two components: net income and Other Comprehensive Income. We decompose the goodwill as Johnson and Petrone (1998) and formalize, based on the residual income valuation model (Ohlson, 1995), a theoretical link between acquired goodwill and subsequent residual comprehensive income. Generalized least squares regressions conducted on companies constituting the SBF 120, for the period 2005 to 2008, show a significant association between acquired goodwill and subsequent residual income of acquiring firms, on the two components of earnings (Net Income and OCI), and also with the Market to Book ratio.
Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata

In eukaryotes, the number and rough organization of chromosomes is well preserved within isolates of the same species. Novel chromosomes and loss of chromosomes are infrequent and usually associated with pathological events. Here, we analyzed 40 pathogenic isolates of a haploid and asexual yeast, Candida glabrata, for their genome structure and stability. This organism has recently become the second most prevalent yeast pathogen in humans. Although the gene sequences were well conserved among different strains, their chromosome structures differed drastically. The most frequent events reshaping chromosomes were translocations of chromosomal arms. However, also larger segmental duplications were frequent and occasionally we observed novel chromosomes. Apparently, this yeast can generate a new chromosome by duplication of chromosome segments carrying a centromere and subsequently adding novel telomeric ends. We show that the observed genome plasticity is connected with antifungal drug resistance and it is likely an advantage in the human body, where environmental conditions fluctuate a lot.
Trends in the Prevalence of Chlamydial Infections: The Impact of Community‐Wide Testing

Background: Evaluation of existing testing programs should guide the national effort to expand programs for the prevention of chlamydial infections. The Columbus (Ohio) Health Department instituted community‐wide testing for Chlamydia trachomatis in 1988. Goals: To assess trends in the prevalence of chlamydial infection, the coverage of screening, and concurrent trends in the prevalence of gonorrhea. Study Design: This was a cross‐sectional study of women 15 to 44 years of age tested for C. trachomatis at over 50 provider sites in Columbus, Ohio, from 1989 to 1992. Results: The prevalence of chlamydial infection among all women tested decreased by 33% from 1989 to 1992. Prevalence decreased least (19%) among black women 15 to 19 years of age, the group with the highest initial prevalence (20.2%), even though 42% of this population in the city was tested. Prevalence did not decrease at all among prenatal patients 15 to 19 years of age. For women tested for both gonorrhea and chlamydia, gonorrhea decreased by 39% during the 4‐year period. Conclusions: Screening appeared to have limited effect on the prevalence of chlamydial infection for groups with highest initial prevalence, despite the relatively high percentage of the population tested. Expanding screening programs to include men and instituting behavioral interventions may be necessary to reduce more rapidly the prevalence of chlamydia among these women.
Smart Cane: Face Recognition System for Blind

We propose a smart cane with a face recognition system to help the blind in recognizing human faces. This system detects and recognizes faces around them. The result of the detection is informed to the blind person through a vibration pattern. The proposed system was designed to be used in real-time and is equipped with a camera mounted on the glasses, a vibration motor attached to the cane and a mobile computer. The camera attached to the glasses sends image to mobile computer. The mobile computer extracts features from the image and then detects the face using Adaboost. We use the modified census transform (MCT) descriptor for feature extraction. After face detection, the information regarding the detected face image is gathered. We used compressed sensing with L2-norm as a classifier. Cane is equipped with a Bluetooth module and receives a person's information from the mobile computer. The cane generates vibration patterns unique to each person as to inform a blind person about the identity of the detected person using the camera. Hence, the blind people can know the person standing in front of them.
Intrinsically Safe Systems-Trends in Design and Installation Standards

Intrinsic safety is a mature proven method to achieve a safe installation of electrical apparatus in a location made hazardous by the presence of flammable or combustible materials. Standards for intrinsically safe apparatus are still evolving. Underwriters' Laboratories, Inc. Standard 913-1975 and NFPA 493-1975 are the most c¿omplete statement of requirements for intrinsically safe apparatus and systems yet published. The forthcoming Instrument Society of America Recommended Practice on installation of intrinsically safe systems will fill a pressing need for an installation guide. The National Electrical Code is also changing to recognize the needs of those in the process industries who use intrinsically safe systems and similar apparatus. Much yet needs to be done to define design constraints and Construction requirements for intrinsically safe apparatus. This work is underway.
Capecitabine: a novel agent for the treatment of solid tumors

Although 5-fluorouracil (5-FU) has been used to treat breast and colorectal cancers for several decades, bolus 5-FU has disappointing efficacy. Prolonged infusion schedules and biomodulation with leucovorin have resulted in improved response rates, but these have not translated into significant improvements in survival in patients with metastatic disease. Furthermore, prolonged infusion is inconvenient for patients and can result in medical complications. New oral fluoropyrimidines, including capecitabine, are promising alternatives to i.v. 5-FU. Capecitabine generates 5-FU preferentially within tumors through exploitation of the high intratumoral activity of thymidine phosphorylase. The tumor selectivity of capecitabine has been confirmed in a clinical study of colorectal cancer patients. Clinical trials have shown that capecitabine is an effective, well-tolerated treatment for breast and colorectal cancer, with response rates of 20-26% in anthracycline- and taxane-pretreated metastatic breast cancer. As first-line monotherapy, capecitabine produces response rates of 25-27% in metastatic colorectal cancer and 30% in metastatic breast cancer. In all studies to date, capecitabine has been well tolerated, with adverse events typical of infusional 5-FU and manageable with treatment interruption/dose modification. Myelosuppression and alopecia are rare. Capecitabine is also being investigated in other solid tumors (including ovarian, pancreatic and gastric cancers) as adjuvant monotherapy in breast and colorectal cancer, and in combination with other cytotoxic agents. Results of ongoing trials are eagerly awaited.
Visual feedback system showing loads on handrails for gait training

Patients with walking difficulties need support devices such as a walker or a cane. However, the support devices sometimes restrict their activities of daily living (ADL). In order to improve the patients' ADL, it is desired that they use the support device that does not restrict their activities as much as possible. The patients need gait training to reduce the dependence on the support device and to switch to a device with fewer restrictions. The purpose of this study is to develop a new visual feedback system that helps the patient receiving gait training to recognize their dependence on the support device. The developed system measures the load that the trainees applied on the handrails, and shows this load graphically by using a display monitor. The walking experiment was carried out with able-bodied subjects in order to ensure that the developed system can give the load feedback to the subjects and they could control the loads on handrails. The experiment was performed in the two cases in which the load information was shown to the subjects, and the load information was not shown to them. During the experiment, the subjects were instructed to adjust the load in accordance with the reference load indicated by the graphical user interface of the developed system. As a result, the subjects could adjust the load to the reference load more appropriately when the load information was given to them. The result, therefore, suggests that the developed system is able to help trainees to be aware of and control the load supported by their arms.
Keeping financialisation under the radar: Brussels Airport, Macquarie Bank and the Belgian politics of privatised infrastructure

This article explores the financialisation of Brussels Airport following the acquisition in 2004 of a majority stake by the Australian Macquarie Bank. Adopting a variegated capitalism perspective, we argue for a greater sensitivity to the mutually constitutive relation between durable institutional governance structures and financialised practices injected by global investors. The case of Brussels Airport presents an informative case to examine this relation, as Macquarie has had to continuously interact with the Belgian federal state in its different guises of contractor, co-owner and regulator to implement financialisation. While Macquarie indeed brought in risks that are structurally associated with profit making through financial means, the governance of these practices is shaped by the Belgian state’s distinctive and pragmatic approach to infrastructure privatisation: the state enables these practices, but also contests them in case of a direct clash with its interests. Meanwhile, the regulatory environment marks the contradictory meeting point of two varieties of capitalism: while the light-handed regulatory framework is inspired by the UK’s airport industry, the Belgian regulator does not possess similar abilities as a UK regulator, and resultantly, informal negotiations between the stakeholders are more influential in the airport’s governance. The case of Brussels Airport shows that the state plays an active role in constituting global capitalism, yet also shapes how financialisation works out on the ground. To understand the tensions that mark the governance of financialised infrastructure, it is therefore imperative to be sensitive to the local, historical and political trajectories that underwrite the variegated outcomes of financialisation.
Effects of Temperature, Water Activity, and Syrup Film Composition on the Growth of Wallemia sebi: Development and Assessment of a Model Predicting Growth Lags in Syrup Agar and Crystalline Sugar

ABSTRACT We investigated the effects of temperature, water activity (aw), and syrup film composition on the CFU growth of Wallemia sebi in crystalline sugar. At a high aw (0.82) at both high (20°C) and low (10°C) temperatures, the CFU growth of W. sebi in both white and extrawhite sugar could be described using a modified Gompertz model. At a low aw (0.76), however, the modified Gompertz model could not be fitted to the CFU data obtained with the two sugars due to long CFU growth lags and low maximum specific CFU growth rates of W. sebi at 20°C and due to the fact that growth did not occur at 10°C. At an aw of 0.82, regardless of the temperature, the carrying capacity (i.e., the cell concentration at t = ∞) of extrawhite sugar was lower than that of white sugar. Together with the fact that the syrup film of extrawhite sugar contained less amino-nitrogen relative to other macronutrients than the syrup film of white sugar, these results suggest that CFU growth of W. sebi in extrawhite sugar may be nitrogen limited. We developed a secondary growth model which is able to predict colony growth lags of W. sebi on syrup agar as a function of temperature and aw. The ability of this model to predict CFU growth lags of W. sebi in crystalline sugar was assessed.
Psychological and social factors in coronary heart disease

Abstract More than six decades of empirical research have shown that psychosocial risk factors like low socio-economic status, lack of social support, stress at work and family life, depression, anxiety, and hostility contribute both to the risk of developing coronary heart disease (CHD) and the worsening of clinical course and prognosis in patients with CHD. These factors may act as barriers to treatment adherence and efforts to improve life-style in patients and populations. In addition, distinct psychobiological mechanisms have been identified, which are directly involved into the pathogenesis of CHD. In clinical practice, psychosocial risk factors should be assessed by clinical interview or standardized questionnaires, and relevance with respect to quality of life and medical outcome should be discussed with the patient. In case of elevated risk, multimodal, behavioural intervention, integrating counselling for psychosocial risk factors and coping with illness, should be prescribed. In case of clinically significant symptoms of depression and anxiety, patients should be referred for psychotherapy, and/or medication according to established standards (especially selective serotonin reuptake inhibitors (SSRIs)) should be prescribed. Psychotherapy and SSRIs appear to be safe and effective with respect to emotional disturbances; however, a definite beneficial effect on cardiac end-points has not been documented.
Only Bad for Believers? Religion, Pornography Use, and Sexual Satisfaction Among American Men

Research has often demonstrated a negative association between pornography use and various intrapersonal and relationship outcomes, particularly for men. Several recent studies, however, have suggested that the negative association between pornography use and these indicators is stronger among more religious Americans, suggesting that moral incongruence (engaging in an activity that violates one’s sacred values) and the attendant shame or cognitive dissonance, rather than pornography use per se, may be the primary factor at work. The current study tested and extended this theory by examining how religion potentially moderates the link between pornography use and sexual satisfaction in a national random sample of American adults (N = 1,501). Analyses demonstrated that while pornography use was negatively associated with sexual satisfaction for American men (not women), among men who rarely attended religious services or held a low opinion of the Bible this negative association essentially disappeared. Conversely, the negative association between frequency of pornography consumption and sexual satisfaction was more pronounced for men with stronger ties to conventional religion. These findings suggest that the connection between pornography use and sexual satisfaction, especially for men, depends largely on what viewing pornography means to consumers and their moral community and less so on the practice itself.
Intraepidermal nerve fiber density as a marker of early diabetic neuropathy

The purpose of the study was to reliably identify an early stage of diabetic polyneuropathy (DPN) by measuring injury to epidermal nerve fibers. We compared intraepidermal nerve fiber density (IENFD) at the ankle and thigh of 29 diabetic subjects who had no clinical or electrophysiological evidence of small‐ or large‐fiber neuropathy to that of 84 healthy controls. The mean ankle IENFD of diabetic subjects was 9.1 ± 5.0 mm and that of controls, 13.0 ± 4.8 mm (P < 0.001). The thigh IENFD did not differ significantly. The IENFD ratio (thigh IENFD divided by ankle IENFD) was 2.39 ± 1.30 in diabetic subjects and 1.77 ± 0.58 in controls (P < 0.001), indicating a length‐dependent reduction of IENFD in diabetics. Ankle IENFD remained significantly lower and the IENFD ratio higher in diabetic subjects after adjusting for age. Two subjects had parasympathetic dysfunction, two had retinopathy, and two early nephropathy. Age, height, weight, duration of diabetes, and average HbA1c did not influence IENFD among diabetic subjects. We used receiver operating characteristic (ROC) curves to describe and compare the utility of various threshold values of ankle IENFD and IENFD ratio for the diagnosis of early DPN. The sensitivity and specificity of diagnosing DPN using ankle IENFD of less than 10 mm were 72.4% and 76.2%, respectively. Thus, asymptomatic diabetics have a measurable, length‐dependent reduction of distal epidermal nerves. Analogous to microalbuminuria in diabetic nephropathy, reliable identification and quantitation of nascent diabetic neuropathy may have potential therapeutic implications. Muscle Nerve, 2007
The insertion allele of the ACE gene I/D polymorphism. A candidate gene for insulin resistance?

BACKGROUND The insertion/deletion (ID) polymorphism of the angiotensin-converting enzyme (ACE) gene has been associated with increased coronary heart disease (CHD), although the mechanism of this association is not apparent. We tested the hypothesis that the deletion allele of the ACE gene is associated with insulin resistance. METHODS AND RESULTS We related ACE genotype to components of the insulin-resistance syndrome in 103 non-insulin-dependent diabetic (NIDDM) and 533 nondiabetic white subjects. NIDDM subjects with the DD genotype had significantly lower levels of specific insulin (DD 38.6, ID 57.1, and II 87.4 pmol.L-1 by ANOVA, P = .011). Non-insulin-treated subjects with the DD genotype had increased insulin sensitivity by HOMA % (DD 56.4%, II 29.4%, P = .027) and lower levels of des 31,32 proinsulin (DD 3.3, II 7.6 pmol.L-1, P = .012) compared with II subjects. There were no differences in prevalence of CHD or levels of blood pressure, serum lipids, or plasminogen activator inhibitor-1 (PAI-1) activity between the three ACE genotypes. In nondiabetic subjects there were no differences in insulin sensitivity, levels of insulin-like molecules, blood pressure, PAI-1, serum lipids, or CHD prevalence between the three ACE genotypes. CONCLUSIONS We conclude that increased cardiovascular risk of the DD genotype is not mediated through insulin resistance or abnormalities in fibrinolysis. Conversely, we report an increased sensitivity in NIDDM subjects with the ACE DD genotype.
Demolition of Existing Buildings in Urban Renewal Projects: A Decision Support System in the China Context

Much of the rapid urbanization of China’s cities has occurred at the expense of the existing urban fabric. Across the nation, whole city blocks have been replaced with new structures, requiring large numbers of buildings to be demolished while still serviceable. This curtailed lifespan of existing buildings not only comes with an economic cost, but results in loss of urban culture, wastes resources, degrades the environment, exacerbates pollution, and inflames social conflict and instability. For the purpose of evaluating the merits of building demolition, this study develops a decision support system (DSS) for building demolition in the China context from the perspective of sustainable urban renewal. The indicators of this system cover economic, social, environmental, and institutional aspects of sustainable development. Meanwhile, both the individual characteristics of buildings and the external or extrinsic indicators at the neighborhood, local, or city level are taken into account. Based on exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), 24 critical indicators containing qualitative and quantitative factors are identified. These indicators are classified into six parameters: (1) service performance; (2) economic impact; (3) social identity; (4) local development; (5) building location; and (6) building safety. Empirical results reveal considerations of local development to be of greatest significance with the value of standardized factor loading standing at 0.911, followed by service performance (loading = 0.870) and building location (loading = 0.863), with social identity (loading = 0.236) ranking substantially lower. The findings contribute to the practice of urban renewal and, in particular, provide practical guidance to the building demolition decision-making process.