Miracle-dz/UniFAR-FTUs huggingface dataset:
Left versus right deceased donor renal allograft outcome

It has been suggested that the left kidney is easier to transplant than the right kidney because of the longer length of the left renal vein, facilitating the formation of the venous anastomosis. There are conflicting reports of differing renal allograft outcomes based on the side of donor kidney transplanted (left or right). We sought to determine the effect of side of donor kidney on early and late allograft outcome in our renal transplant population. We performed a retrospective analysis of transplanted left–right deceased donor kidney pairs in Ireland between January 1, 1998 and December 31, 2008. We used a time to death‐censored graft failure approach for long‐term allograft survival and also examined serum creatinine at different time points post‐transplantation. All outcomes were included from day of transplant onwards. A total of 646 transplants were performed from 323 donors. The incidence of delayed graft function was 16.1% in both groups and there was no significant difference in acute rejection episodes or serum creatinine from 1 month to 8 years post‐transplantation. There were 47 death‐censored allograft failures in the left‐sided group compared to 57 in the right‐sided group (P = 0.24). These observations show no difference in renal transplant outcome between the recipients of left‐ and right‐sided deceased donor kidneys.
Regional estimates of the price elasticity of demand for natural gas in the United States

A misalignment of incentives in the gas pipeline construction process has caused growth of gasfired generation to outpace investment in new pipelines in New England. Limited gas capacity to the region has resulted in power reliability issues, particularly during severe winter weather when gas demand is high. The majority of proposed solutions have focused on increasing gas supply. However, demand response in the natural gas retail market is a potential alternative answer. To quantify the benefits of gas demand response regional and state level price elasticities of demand for natural gas must be known. In this thesis, the price elasticity of demand for natural gas in the U.S. was estimated for the period 2001 to 2014 at the national, regional and state levels for the residential, commercial and industrial sectors. Differences in demand estimates were observed when performed at the different aggregate data levels and sectors. However, not all the regional and state estimates obtained for each sector showed statistically significant differences from each other or the national level. The short-run regional estimates for New England were used in a simple demonstration of gas demand response to show how they could have been used to mitigate the effects of the 2014 cold snap on electricity generation. Prices were optimized such that they reduced gas demand from retail markets by the amount of fuel that generators were short while minimizing the total deadweight loss.
Is There a Relationship between TELs and Default? Evidence from US Municipalities

The economic effects of tax and expenditure limits (TELs) have been often studied in the literature. However, little research has addressed how TELs might influence the propensity for a jurisdiction to default on its obligations. This study specifically fills that void. Overall, the results indicate that while the likelihood of default increases as TELs become more restrictive, the magnitude is not particularly large. Once decomposed, it would appear that property tax limits increase the likelihood, while expenditure limits have the opposite effect, though the latter result is insignificant. The findings are robust to a number of specifications and provide potential policy implications. Los efectos economicos de los limites de impuestos y gastos (TEL, por sus siglas en ingles) se han estudiado a menudo en la literatura. Sin embargo, pocos estudios han abordado la forma en que los TEL podrian influir en la propension de una jurisdiccion a incumplir sus obligaciones. Este estudio llena ese vacio especifico. En general, los resultados indican que, si bien la probabilidad de incumplimiento aumenta a medida que los TEL se vuelven mas restrictivos, la magnitud no es particularmente grande. Una vez desagregados, parece ser que los limites del impuesto sobre inmuebles aumentan la probabilidad, mientras que los limites en el gasto tienen el efecto contrario, aunque este ultimo resultado no es significativo. Los resultados son robustos respecto a una serie de especificaciones y ofrecen posibles implicaciones para las politicas. 税および支出に関する制限事項 (tax and expenditure limits: TELs)の経済効果については、これまでに多数の論文において検討されてきた。 しかし、TELsがどのように租税管轄が債務不履行に陥る傾向に影響を与え得るのかについて取り組んだ研究はほとんど行われておらず、本研究は特にその空白を埋めるものである。 概して、結果からTELsによる制限が強くなるほど債務不履行に陥る確率が上昇するものの、その規模は特に大きいわけではないことが指摘される。 分析によると、固定資産税の制限が債務不履行に陥る確率を上げ、一方で支出の制限はその反対の効果があると考えられるが、後者の結果は取るに足らないものである。 この知見は、多数の仕様に対して頑健であり政策的な意義を有すると考えられる。
Histamine: A Neurotransmitter Candidate for Drosophila Photoreceptors

: Recent experimental evidence suggests that histamine might be the synaptic transmitter used by invertebrate photoreceptors. In the present study, we have examined whether histamine is a transmitter candidate for Drosophila photoreceptors. Our findings are as follows; (a) Large amounts of histamine are synthesized by wild‐type heads, whereas heads from the eye‐deficient mutants, eyes absent and sine oculis, show reduced histamine synthesis, (b) Histidine de‐carboxylase activity is ⋍ 10‐fold higher in extracts of normal heads compared with that ia the mutants, (c) Histamine taken up by fly heads is metabolized into N‐acetylhistamine and imidazole‐4‐acetic acid, (d) Immunostaining of normal and sevenless heads with histamine‐specific antisera demonstrates that histamine is present in photoreceptors R1–6 and R8. (e) Histamine synthesized from exogenously supplied [3H]‐histidine can be released by depolarization with 50 mM K+, and the release is Ca2+ dependent. These observations strongly suggest that histamine is a major neurotransmitter used by Drosophila photoreceptors.
Descriptive Ecology of a Turtle Assemblage in an Urban Landscape

Abstract We studied turtle populations inhabiting a canal and a lake (both man-made) within a heavily disturbed, urban setting. Six aquatic and semi-aquatic turtle species were collected in both habitats: spiny softshell turtle (Apolone spinifera), painted turtle (Chrysemys picta), common snapping turtle (Chelydra serpentina), common map turtle (Graptemys geographica), common musk turtle (Sternotherus odoratus) and red-eared slider (Trachemys scripta). While G. geographica was the most common species in the canal habitat, T. scripta was most common in the lake habitat. We describe patterns of sexual size dimorphism and sex ratios for the three most abundant species (G. geographica, T. scripta and S. odoratus). We discuss our data in light of problems facing turtle assemblages in urban settings.
Proteomic analysis of the acid‐soluble organic matrix of the chicken calcified eggshell layer

The major difference between inorganic minerals and biominerals is the presence of an organic matrix consisting of proteins, glycoproteins, proteoglycans, and polysaccharides, which is synthesized by specialized cells under genetic control before or during mineralization. The organic matrix is thought to play a major role in the assembly of the biomineral and determination of its mechanical properties. The recent elucidation of the chicken genome provided an opportunity to explore the matrix proteome of a biomineral using up‐to‐date MS‐based technology. We identified 520 proteins in this matrix including the ten matrix proteins already known before. The identified proteins were divided into three abundance groups using the exponentially modified protein abundance index described recently which was roughly calibrated with the few known data on protein yield derived from Edman sequence analysis. A small group of 32 highly abundant proteins contained the presently known eggshell‐specific proteins and all of the other known eggshell matrix constituents identified before with much less sensitive conventional methods. The present study, which is the first comprehensive proteomic study of a vertebrate biomineral, is intended as a starting point for the detailed molecular characterization of eggshell matrix proteins, their interactions in the matrix network and functional studies.
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma

ERK and RSK2 drive proliferation and invasion of many cancers. Phosphoprotein enriched in astrocytes 15 (PEA15) binds ERK and RSK2 and high PEA15 levels can impair ERK‐ and RSK2‐dependent transcription. PEA15 expression also inversely correlates with cell motility and invasiveness. We therefore tested PEA15 effects on neuroblastoma cells in vitro. We further analyzed PEA15 expression in the context of clinical and genetic features of neuroblastoma in tumor samples to determine its correlation with disease progression. Affymetrix microarray analysis was performed using 24 different neuroblastoma cell lines. Cell lines expressing low to intermediate levels of PEA15 were chosen for in vitro functional studies. The cell line results were verified by Affymetrix analysis of three different neuroblastic tumor types (total of 110 samples) PEA15 overexpression inhibited neuroblastoma migration in vitro. We verified that inhibition of motility required PEA15 interaction with its binding partners ERK and RSK2. Additionally, synthetic inhibitors of RSK2 suppressed integrin‐dependent migration. PEA15 expression correlates with clinical parameters and a 25% increase in patient survival rate. The highest PEA15 levels were found in low stage, more differentiated and less metastatic neuroblastic tumors, and correlated with lack of MYCN amplification. PEA15 blocks neuroblastoma migration through inhibition of ERK/RSK2 signaling. PEA15 expression levels correlate with favorable clinical features suggesting that PEA15 limits metastatic progression of neuroblastoma. Thus, PEA15 and its partners ERK and RSK2 are potential targets for the development of new therapeutics to impede progression of minimal residual disease in patients with high‐risk neuroblastoma.
Specific and nonspecific mechanisms involved in generation of PAD of group Ia afferents in cat spinal cord.

In the spinal cord of the anesthetized cat, we measured the changes in extracellular concentration of potassium ions [K+]e and the negative DC shifts produced by stimulation of muscle, cutaneous and mixed afferent nerves, together with alterations in the threshold of single group Ia fibers that were tested at the same site as the potassium measurements. This approach provided information on the extent to which the excitability changes of single Ia-fibers can be correlated with the changes in [K+]e occurring at the same site. Stimulation of the tibial (TIB) nerve and of the cutaneous sural (SU), and superficial peroneous (SP) nerve (100-Hz trains lasting 30-60 s) with stimulus strengths of 10-15 times threshold increased the concentration of [K+]e in the dorsal horn by 2-5 mmol/l above the resting value of 3 mmol/l. This was in clear contrast with the very small [K+]e increases produced at the same site during stimulation of muscle nerves, such as the posterior biceps and semitendinosus (PBSt), gastrocnemius soleus (GS), and deep peroneus (DP), which were generally smaller than 0.25 mmol/l. Stimulation of the PBSt and GS muscle nerves did produce small, but clear, increases of [K+]e (up to 0.3 mmol/l) in the region of the intermediate nucleus, where these fibers synapse with second order cells. These changes were nevertheless smaller than those produced at the same site by stimulation of the TIB, SU, and SP nerves. The peak amplitudes of the [K+]e transients produced by long-lasting 100-Hz trains applied to cutaneous and/or to muscle nerves showed a linear relationship with the amplitudes of the slow negative DC shifts, which were simultaneously recorded from the NaCl barrel of the potassium electrode assembly. Stimulus trains (100 Hz) applied to group I muscle afferents (PBSt and DP) very effectively reduced the threshold for intraspinal activation of individual group I GS fibers but produced negligible negative DC shifts at the same site. On the other hand, 100-Hz stimulus trains applied to the SU and SP nerves produced large negative DC shifts, even with low-stimulus strengths (2 X T, where T is threshold), but had much smaller effects on the threshold of group Ia GS fibers. Increasing the intensity of the stimuli applied to cutaneous and mixed nerves above 2 X T strength further reduced the threshold of the Ia-fibers. (ABSTRACT TRUNCATED AT 400 WORDS)
Economic integration and export complexity: the case of Slovakia

The goal of the article is to evaluate the impact of the European Union (EU) accession on the complexity of goods in Slovak exports. The traditional theories or trade (Ricardian and Heckscher-Ohlin models) show that such an engagement in economic integration may lead to specialization in the production of either more or less sophisticated goods, depending on the country’s technological advancement and factor endowment. At the same time, increased FDI flows may stimulate the engagement of a country in international production chains with ambiguous effects on export complexity. Because it is impossible to a priori predict the effect economic integration may have on the complexity, it is reasonable to verify it empirically. The authors used the Synthetic Control Method (SCM) to compare the observed post-accession levels of exports complexity in Slovakia with the counterfactual values of that country remaining outside of the EU. The obtained results show that the accession led to an increase in complexity of exported goods.
Victim and Offender Self-Reports of Alcohol Involvement in Crime

Research suggests that a decreasing share of violent crime is attributable to offenders who had been drinking alcoholic beverages. Surveys of victims indicate that the rate of alcohol-involved violent crimes (i.e., crimes in which the perpetrators had been drinking, as perceived by the victims) decreased 34 percent from 1993 to 1998, whereas the rate of non-alcohol-involved violence decreased 22 percent. Surveys of some offenders also suggest that alcohol’s role in violence is decreasing. The decrease in alcohol-involved violence is consistent with declines in other measures of alcohol use and misuse, including per capita alcohol consumption and alcohol involvement in traffic crashes. In contrast, violent offenders in State prisons are increasingly likely to report having used alcohol before committing their offenses, possibly illustrating the effect of more severe sanctions for alcohol-involved offenses.
Gastroprotective effect of (‐)‐myrtenol against ethanol‐induced acute gastric lesions: possible mechanisms

(‐)‐Myrtenol is a natural fragrance monoterpenoid structurally related to α‐pinene found in diverse plant essential oils. This study was aimed to assess the anti‐ulcerogenic potential of (‐)‐myrtenol against ethanol‐induced gastric lesions and to elucidate the underlying mechanism(s).
The influence of syllable position on children's production of consonants

Two studies examined consonant production by 13 children with delayed phonological skills. Study 1 examined patterns of substitution errors in word-initial, word-final and intervocalic positions of two-syllable words with a strong-weak stress pattern. For phonemes that were misarticulated in at least one word position, intervocalic consonant production was most likely to be the same as the word-final consonant production, but different from the word-initial consonant production. Study 2 examined proportions of matches and mismatches for features in five positions of multisyllabic words: (1) syllable-initial, word-initial, (2) syllable-initial, within-word, (3) intervocalic before an unstressed syllable, (4) syllable-final, within-word, and (5) syllable-final, word-final. Significant variations in match ratios were observed as a function of syllable position. A number of different patterns of position-dependent errors were observed.
A 34.1fps scale-space processor with two-dimensional cache for real-time object recognition

A scale-space processor with two-dimensional cache is proposed to achieve real-time object recognition in HD 720p images. Scale-space is the most commonly used concept to achieve scale-invariant property in object recognition, however its high computational cost makes it hard to implement a realtime object recognition processor. We employ hierarchical convolution unit (HCU) which computes multiple pixels in a single cycle with various kernel sizes. In addition, two-dimensional cache (T-Cache) supports accessing vertically consecutive data from any image window size with reduced area. A pre-fetch controller for the proposed cache improves the hit rate by exploiting the sequential access pattern of convolution tasks. As a result, the scale-space processor implemented in a 0. 13μm CMOS technology achieves 34.1fps on a HD 720p image while consuming peak power of 84.5mW.
Interactions between adipose tissue around lymph nodes and lymphoid cells in vitro.

The functional relationships between lymphoid cells and the adipose tissue that surrounds lymph nodes were investigated in healthy adult guinea pigs. Lymphoid cells extracted from healthy adult guinea pigs were co-cultured for 48 h with adipose tissue explants from 18 sites defined by their anatomical relations to lymph nodes. Such explants from near a node suppressed lymphocyte proliferation stimulated with concanavalin A or lipopolysaccharide more than those from sites 5-10 mm from nodes. Inhibition was almost completely abolished by 500 microU insulin. The presence of lymphoid cells increased lipolysis (measured as glycerol release) in adipose tissue from all depots containing lymph nodes (i.e., except perirenal), especially in the presence of mitogens and with near-node samples from intermuscular and mesenteric depots. Inhibition of lymphocyte proliferation by adipose tissue was proportional to the additional lipolysis stimulated by the presence of lymphoid cells. For all depots except the mesenteric, glycerol release stimulated by lymphoid cells was inversely proportional to spontaneous lipolysis in adipose tissue cultured alone. These experiments demonstrate reciprocal interactions between lymphoid cells and adipose tissue, especially that around lymph nodes. The mediators of the action of adipose tissue on lymphoid cells probably include lipolytic products; mediators of the inverse effects are unknown.
Excretion of extracellular lipids by Streptococcus mutans BHT and FA-1

Streptococcus mutans BHT and FA-1, when grown to log phase on chemically defined medium containing [14C]glycerol, excreted 15% of the total biosynthesized 14C-lipid into the medium. When grown to early stationary phase, 28 to 33% of the 14C-lipid was found in the medium. The radioactive lipids of these varieties of S. mutans were identified as diacylglycerol, diglucosyl diacylglycerol (DGD), monoglucosyl diacylglycerol, diphosphatidylglycerol, phosphatidylglycerol (PG), and smaller amounts of two other lipids tentatively were identified as amino acyl-PG and glycerol phosphoryl-DGD. All lipids were found as extracellular and intracellular components from cells grown to either log or stationary phase. However, there were some shifts in the relative percentage of these lipids as the cells changed from log to stationary phase. For example, the intracellular lipid content of log-phase S. mutans BHT was composed of 49% PG and 19% DGD, but these percents shifted to 18% PG and 57% DGD when the cells were grown to stationary phase. However, the extracellular lipids of this organism contained 50 to 60% PG and 20% DGD in both log and stationary phases.
Human-Like Walking: Optimal Motion of a Bipedal Robot With Toe-Rotation Motion

Fast human walking includes a phase where the stance heel rises from the ground and the stance foot rotates about the stance toe. This phase where the biped becomes underactuated is not present during the walk of current humanoid robots. The objective of this study is to determine whether the introduction of this phase for a 3-D bipedal robot is useful to reduce the energy consumed in the walking. In order to study the efficiency of this new gait, two cyclic gaits are presented. The first cyclic motion is composed of successive single-support phases with a flat stance foot on the ground, and the stance foot does not rotate. The second cyclic motion is composed of single-support phases that include a subphase of rotation of the supporting foot about the toe. The single-support phases are separated by a double-support phase. For simplicity, this double-support phase is considered as instantaneous (passive impact). For these two gaits, optimal motions are designed by minimizing the torques cost. The given performances of actuators are taken into account. It is shown that, for a fast motion, a foot-rotation subphase is useful to reduce the cost criterion. These gaits are illustrated with simulation results.
Interactive shape acquisition using marker attached laser projector

A 3D shape acquisition system consisting of a laser projector and a video camera is described. A user projects a stripe of light to the measured 3D scene by hand. The projected light and LED markers attached to the laser projector are captured with the video camera. By estimating the 3D pose of the laser projector from the 2D locations of the markers, the distance to the surface lit by the laser can be calculated. The use of a laser projector that projects a stripe of light enables correction of shape estimation errors from known 3D surfaces. With this system, the user can measure the 3D shapes of objects in real time, thereby confirming the shape acquisition of each part of the surface.
Elevated circulating CD40L concentrations in patients with systemic sclerosis.

OBJECTIVE B cell activation, fibrosis, and expression of adhesion molecules on endothelial cells are regulated by soluble CD40L (sCD40L)/CD40 interactions. Since these effects are characteristic in patients with systemic sclerosis (SSc), serum concentrations of sCD40L were determined in patients with SSc. METHODS Fifty-two Japanese patients with SSc were examined. They were grouped into 24 patients with limited cutaneous SSc (lSSc) and 28 with diffuse cutaneous SSc (dSSc). Serum sCD40L levels were examined by ELISA. As a disease control, serum samples from 20 patients with systemic lupus erythematosus (SLE) were also examined. In addition, a retrospective longitudinal study was performed in 71 serum samples from 18 patients with SSc. RESULTS Serum sCD40L levels were elevated in SSc patients compared with healthy controls (p < 0.001). Levels of sCD40L in patients with SSc were higher than in patients with SLE (p < 0.001) that had elevated sCD40L levels compared with healthy controls. Among SSc subsets, there were no differences in sCD40L levels between lSSc and dSSc. sCD40L levels correlated positively with C-reactive protein levels in SSc patients (p < 0.0001, r = 0.449). In a cross-sectional study and a longitudinal study, serum sCD40L levels in dSSc patients were persistently elevated, although those in lSSc patients were temporarily elevated at the early phase of the disease process. CONCLUSION Patients with SSc exhibited elevated sCD40L levels that may correlate with disease activity. These results suggest that CD40/CD40L interactions may be potential therapeutic targets in SSc.