Miracle-dz/UniFAR-FTUs huggingface dataset:
Miniaturized power dividers with integrated bandpass response based on BAW coupled resonator filters

With the spectrum more and more overcrowded, filters and duplexers are drivers of the technology in the discrete device mobile market. The user segment of wireless communication systems leverages the outstanding performance of filtering devices based on acoustic wave resonators. But so far, these technologies have not covered the rest of the RF passive elements in a Front End Module. The use of Bulk Acoustic Wave technology overcomes the miniaturization issue. The acoustic technology exhibits key properties which allow a significant size reduction. In an RF-Front End Module, the passive devices are under continuous pressure to shrink. Some conventional power dividers are not adequate for the high level of miniaturization demanded. To contribute on the size reduction demands of dividers, we have studied two different topological designs which applies bulk acoustic wave technology. Specifically the two proposed devices are based on Coupled Resonators Filter structures. Guidelines for the design of both 3-dB power dividers are described on this paper. We illustrate the designs with two splitters based on the two topologies for application on W-CDMA and their simulated performances. Both dividers have embedded passband filtering responses and have all the ports matched. Furthermore, the designed splitters simplify the fabrication of CRF because almost all the multilayer films are uniform.
Formalin Instillation for Hemorrhagic Radiation Proctitis

Although formalin instillation has been proven to be an effective treatment of hemorrhagic radiation proctitis, different tech niques with varying success rates have been reported. The aim of this study was to assess our experience with formalin instillation for the treatment of radiation proctitis. After Institutional Review Board approval, all patients who presented with radiation proctitis and were treated with 4% formalin instillation were identified from a prospective database. Techniques of instillation were as follows: a formalin-soaked sponge stick was applied via a proctoscope (SS) and placed at each quadrant with a mean contact of 2.5 minutes (range, 0.5-3 minutes), or the formalin solution was introduced through a proctoscope in aliquots for a total of 350 to 400 mL irrigation (IR), with a mean contact time of 30 seconds in each aliquot. The patients were divided into two groups according to the method of formalin instillation and their outcomes were compared. Between March 1995 and September 2003, 21 patients who underwent formalin treatment were identified: 17 patients were in the SS and 4 patients were in the IR group. The mean age was 74.8 6.4 years and 70.5 6.8 years and the male/female ratio was 16:1 and 3:1 in the SS and IR groups, respectively. Indications for radiation therapy were prostate cancer in 19 patients: 16 (95.1%) SS patients and 3 (75%) IR patients. Four (23.5%) patients in the SS group were receiving anticoagulants or antiplatelet medications before the procedure. The mean duration of bleeding before formalin instillation was 11.7 months (range, 2-48 months) in the SS and 10.5 months (range, 7-12 months) in the IR group. Sixteen (94.1%) patients in the SS and 4 (100%) in the IR group had previous treatments for radiation proctitis, including hydrocortisone enema, 5-aminosalicylate mesalamine, and endoscopic coagulation. Eight (47.1%) patients in the SS and 2 (50%) in the IR group received a preprocedural blood transfusion, and 1 patient in the SS group required a blood transfusion after the formalin instillation. This patient subsequently underwent restorative proctosigmoidectomy because of persistent bleeding. The mean length of the procedure was 27.1 10.8 minutes in the SS group and 22.5 6.5 minutes in the IR group. The bleeding was successfully stopped on the first attempt in 14 patients (82.4%) in the SS group and 3 (75%) in the IR group. The instillation was repeated in 1 patient (5.9%) in the SS group and in 1 (25%) in the IR group. Four patients (23.5%) in the SS group experienced rectal pain after the procedure. One patient (5.9%) developed a new onset of fecal incontinence, while another (5.9%) had anococcygeal pain accompanied by worsening of fecal incontinence. One patient (25%) in the IR group developed acute colitis consistent with formalin instillation, which was managed by intravenous antibiotics. The patients were followed for a mean of 10 months (range, 1 to 38 months). Formalin instillation is effective in controlling refractory hemorrhage secondary to radiation proctitis.
NO REST FOR THE WOUNDED: EARLY AMBULATION AFTER HIP SURGERY ACCELERATES RECOVERY

Background: Level 3 evidence‐based guidelines recommend first walk after hip fracture surgery within 48 h. Early mobilization is resource and effort intensive and needs rigorous investigation to justify implementation. This study uses a prospective randomized method to investigate the effect of early ambulation (EA) after hip fracture surgery on patient and hospital outcomes.
High-quality MNS capacitors prepared by jet vapor deposition at room temperature

The properties of metal-nitride-Si (MNS) capacitors in which the silicon nitride layer is produced by the jet vapor deposition (JVD) technique at room temperature are reported. Despite the room-temperature deposition, the electrical properties of these devices are far better than any previously reported MNS capacitors. Especially remarkable is the low density of interface traps (D/sub it/<5*10/sup 10//cm/sup 2/-eV near midgap). In addition, these MNS capacitors are highly resistant to damage caused by hot electrons and ionizing radiation. <<ETX>>
Improvement of Resistive Switching Characteristic in Silicon Oxide-Based RRAM Through Hydride- Oxidation on Indium Tin Oxide Electrode by Supercritical CO2 Fluid

Supercritical carbon dioxide (SCCO2) fluid technology was applied to indium-tin-oxide (ITO) electrode to improve the resistive switching characteristic of silicon oxide RRAM through hydride oxidation for the first time. We found device power consumption can be effectively reduced so that side effects can be also restricted under device operation. By applying SCCO2 fluid, more oxygen ions will be introduced into the ITO electrode and thus the participation of net oxygen ions in the RRAM redox reaction will increase. Fourier transform spectroscopy and X-ray photoelectron spectroscopy were used to confirm hydride oxidation on ITO electrode. Combined with the current fitting results, we proposed a reaction model to explain the improvement of resistive switching in RRAM by SCCO2 fluids.
Bayesian Fourier clustering of gene expression data

ABSTRACT Clustering gene expression data are an important step in providing information to biologists. A Bayesian clustering procedure using Fourier series with a Dirichlet process prior for clusters was developed. As an optimal computational tool for this Bayesian approach, Gibbs sampling of a normal mixture with a Dirichlet process was implemented to calculate the posterior probabilities when the number of clusters was unknown. Monte Carlo study results showed that the model was useful for suitable clustering. The proposed method was applied to the budding yeast Saccaromyces cerevisiae and provided biologically interpretable results.
Suppression of anomalous clutter caused by evaporation duct propagation

Microwave propagation is adversely affected by evaporation duct, which can occur as often as 85% of the time in the sea of the world [1]. Evaporation duct propagation is the abnormal bending and diversion of electromagnetic radiation from the intended paths, that resulting in the problems of extended propagation of microwave signals well beyond the radio horizon, high probability of intercept, measurement errors, radar holes, and anomalous clutter [2]. A kind of anomalous clutter caused by evaporation duct propagation is described through analysis of experimental data collected from an S-band search radar. To suppress the anomalous clutter, a MTI processing with entropy detection is proposed, which utilizes the weak correlation characteristic and the certain position relation between anomalous clutter echoes. Compared with normal MTI processing, it can suppress anomalous clutter effectively and the performance is validated by simulation of the experimental data.
Media integration in multimodal interfaces

Combining several modalities in the same interface requires certain characteristics from input and output devices and the ability to provide some specific information which is important at the technical level. Unfortunately, several of the current devices do not provide such information. The reason is simple: they have been designed keeping in mind that they will be used in an isolated way, not in combination with other devices. We describe the specific requirements revealed by our practical experience when designing multimodal interfaces.
Therapy for lysosomal storage disorders

In the last years, much progress has been achieved in the field of lysosomal storage disorders. In the past, no specific treatment was available for the affected patients; management mainly consisted of supportive care and treatment of complications. As orphan drug regulations, however, encouraged development of drugs for these disorders by granting marketing exclusivity for 10 years and other commercial benefits, enzyme replacement therapy became available for lysosomal storage disorders, such as Gaucher disease, Fabry disease, mucopolysaccharidoses type I, II, and VI, and Pompe disease. This review will summarize the efficacy and clinical status of hematopoietic stem cell transplantation, enzyme replacement, and substrate deprivation therapy, and describe new therapeutic perspectives currently under preclinical investigations such as chaperone‐mediated therapy, stop‐codon read‐through therapy, and gene therapy. © 2009 IUBMB IUBMB Life, 62(1):33–40, 2010
FAST AXOPLASMIC TRANSPORT OF A CALCIUM‐BINDING PROTEIN IN MAMMALIAN NERVE

Abstract— Calcium is transported at a fast rate of 410 mm/day in cat sciatic nerve on injection of 45Ca2+ into the L7 dorsal root ganglia. Nerve segments corresponding to the crest and the plateau regions of transported activity were analyzed by column chromatography on Sephadex G‐100 and Biogel A 5m columns and the fast transported 45Ca2+ found to be bound to a protein of 15,000 dalton. Using [3H]leucine as a precursor, a labeled calcium binding protein (CaBP) was found located at the same position in elution volumes from the columns as was the protein‐bound 45Ca2 +. The level of [3H]‐labeled CaBP in the crest and plateau regions were compared using column chromatography and polyacrylamide gel electrophoresis techniques and approx 3×4 times more [3H]‐labeled activity was found in the crest as compared to the plateau. These findings indicate that Ca2+ is fast transported in association with the CaBP. The relation of CaBP to the transport filament model of axoplasmic transport and its possible role in nerve are discussed.
Toward Alignment between Communities of Practice and Knowledge-Based Decision Support

The National Repository of Digital Forensics Information (NRDFI) is a knowledge repository for law enforcement digital forensics investigators (LEDFI). Over six years, the NRDFI has undertaken significant design revisions in order to more closely align the architecture of the system with theory addressing motivation to share knowledge and communication within ego-centric groups and communities of practice. These revisions have been met with minimal change in usage patterns by LEDFI community members, calling into question the applicability of relevant theory when the domain for knowledge sharing activities expands beyond the confines of an individual organization to a community of practice. When considered alongside an empirical study that demonstrated a lack of generalizability for existing theory on motivators to share knowledge, a call for deeper investigation is clear. In the current study, researchers apply grounded theory methodology through interviews with members of the LEDFI community to discover aspects of community context that appear to position communities of practice along a continuum between process focus and knowledge focus. Findings suggest that these contextual categories impact a community’s willingness to participate in various classes of knowledge support initiatives, and community positioning along these categories dictates prescription for design of knowledge based decision support systems beyond that which can be found in the current literature.
Grasping convergent evolution in syngnathids: a unique tale of tails

Seahorses and pipehorses both possess a prehensile tail, a unique characteristic among teleost fishes, allowing them to grasp and hold onto substrates such as sea grasses. Although studies have focused on tail grasping, the pattern of evolutionary transformations that made this possible is poorly understood. Recent phylogenetic studies show that the prehensile tail evolved independently in different syngnathid lineages, including seahorses, Haliichthys taeniophorus and several types of so‐called pipehorses. This study explores the pattern that characterizes this convergent evolution towards a prehensile tail, by comparing the caudal musculoskeletal organization, as well as passive bending capacities in pipefish (representing the ancestral state), pipehorse, seahorse and H. taeniophorus. To study the complex musculoskeletal morphology, histological sectioning, μCT‐scanning and phase contrast synchrotron scanning were combined with virtual 3D‐reconstructions. Results suggest that the independent evolution towards tail grasping in syngnathids reflects at least two quite different strategies in which the ancestral condition of a heavy plated and rigid system became modified into a highly flexible one. Intermediate skeletal morphologies (between the ancestral condition and seahorses) could be found in the pygmy pipehorses and H. taeniophorus, which are phylogenetically closely affiliated with seahorses. This study suggests that the characteristic parallel myoseptal organization as already described in seahorse (compared with a conical organization in pipefish and pipehorse) may not be a necessity for grasping, but represents an apomorphy for seahorses, as this pattern is not found in other syngnathid species possessing a prehensile tail. One could suggest that the functionality of grasping evolved before the specialized, parallel myoseptal organization seen in seahorses. However, as the grasping system in pipehorses is a totally different one, this cannot be concluded from this study.
ARCHONS: a highly multiplexed superconducting optical to near-IR camera

We report on the development of ARCONS, the ARray Camera for Optical to Near-IR Spectrophotometry. This photon counting integral field unit (IFU), being built at UCSB and Caltech with detectors fabricated at JPL, will use a unique, highly multiplexed low temperature detector technology known as Microwave Kinetic Inductance Detectors (MKIDs). These detectors, which operate at 100 mK, should provide photon counting with energy resolution of R = E/δE > 20 and time resolution of a microsecond, with a quantum efficiency of around 50%. We expect to field the instrument at the Palomar 200" telescope in the first quarter of 2011 with an array containing 1024 pixels in a 32×32 pixel form factor to yield a field of view of approximately 10×10 arcseconds. The bandwidth of the camera is limited by the rising sky count rate at longer wavelengths, but we anticipate a bandwidth of 0.35 to 1.35 μm will be achievable. A simple optical path and compact dewar utilizing a cryogen-free adiabatic demagnetization refridgerator (ADR) allows the camera to be deployed quickly at Naysmith or Coud´e foci at a variety of telescopes. A highly expandable software defined radio (SDR) readout that can scale up to much larger arrays has been developed.
Expression of CD 14 and toll-like receptors 2 and 4 by milk neutrophils in bovine mammary glands infected with Corynebacterium bovis 1

Blagitz M.G. , Souza F.N. , Batista C.F. , Santos B.P., Parra A.C. , Azevedo L.F. F. & Della Libera A.M.M.P. 2015. Expression of CD14 and toll-like receptors 2 and 4 by milk neutrophils in bovine mammary glands infected with Corynebacterium bovis. Pesquisa Veterinária Brasileira 35(1):1-5. Departamento de Clínica Médica, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Prof. Dr. Orlando Marques de Paiva 87, Cidade Universitária, São Paulo, SP 05508-270, Brazil. E-mail: magblagitz@uol.com. br This study evaluated the expression of CD14, toll-like receptor (TLR) 2 and TLR4 on the surface of milk neutrophils in bovine mammary glands infected with Corynebacterium bovis. Here, we used 23 culture-negative control quarters with no abnormal secretion on the strip cup test and milk somatic cell count lower than 1x105 cells/mL, and 14 C. bovis infected quarters. The identification of neutrophils, as well as, the percentage of neutrophils that expressed CD14, TLR2 and TLR4 were analyzed by flow cytometry using monoclonal antibodies. The present study encountered no significant difference in the percentages of milk neutrophils that expressed TLR2 and TLR4 or in the expression of TLR4 by milk neutrophils. Conversely, a lower median fluorescence intensity of TLR2 in milk neutrophils was observed in C. bovis-infected quarters. The percentage of neutrophils that expressed CD14 and the median fluorescence intensity of CD14 in milk neutrophils was also lower in C. bovis-infected quarters.
Reconsidering medication appropriateness for patients late in life.

P ROVIDING GUIDELINEadherent care for many medical conditions increasingly means the addition of more medications to reach disease-specific targets. When might it be best to withhold or discontinue medications that are otherwise appropriate on the basis of guidelines? Receiving facsimiles from the pharmacy serving a local nursing home encouraging us to prescribe statins for residents there symbolizes the issues. Most of these patients had a limited life expectancy,wereolder than90years, orhad advanced dementia. Similar situations occur in patients with functional impairments, frailty, or diseases like emphysema, congestive heart failure, or coronary artery disease in their advanced stages, for whom starting or continuing many recommended drugs does not seem the best way to optimize care. Investigators in a number of studies havecharacterized inappropriate prescribing in the elderly, but there is little informationtoguidediscontinuation of otherwise indicated medications inpatients late in life.We proposeaprocess formedicationprescribing in patients late in life that builds on the principles of appropriateprescribingandincludesaconsideration of remaining life expectancy, goalsof care, andpotentialbenefitsof medications.Weusecasescenarios to illustratethismodelanddiscusstheimplications of this approach.
Validation of the Saadat NIBP module according to the ANSI/AAMI-SP10 protocol

This study is conducted with the aim of validating the Saadat non-invasive blood pressure (NIBP) module accuracy and reliability against direct intra arterial pressure measurement (IBP) according to the ANSI/AAMI SP10-2002 guidelines. Measurement and comparison procedure were done in a static population of 19 adult patients with brachial catheterized arterial line with total measurements of 195 under supervision of a highly experienced cardiovascular anesthesiologist in accordance with the ANSI/AAMI SP10-2002 regulation. Data analysis was performed based on the protocol criteria. In order to represent relationships between the test device and the reference method, Bland-Altman graphical plotting method was used. The mean ± SD differences between the readings of Saadat NIBP device and IBP as the reference method for systolic, diastolic and map pressures were: -0.9 ± 6.95 mmHg for systolic, 2.57 ± 7.79 mmHg for Diastolic, and 3.89 ± 7.06 mmHg for Map. The Saadat NIBP module fulfilled the ANSI/AAMI SP10-2002 requirement that is the mean ± SD of lower than 5 ± 8 mmHg.
Insulin reduces the multiple organ injury and dysfunction caused by coadministration of lipopolysaccharide and peptidoglycan independently of blood glucose: Role of glycogen synthase kinase-3&bgr; inhibition*

Objective:Insulin reduces morbidity and mortality among critically ill patients, but the molecular mechanisms of its effect remain unknown. Insulin is a well-known inhibitor of glycogen synthase kinase-3, which may play an important role in systemic inflammation and shock. Here we investigate the role of blood glucose and glycogen synthase kinase-3&bgr; inhibition in the protective effect of insulin on the organ injury/dysfunction associated with excessive systemic inflammation. Design:Prospective, randomized study. Setting:University-based research laboratory. Subjects:Eighty-five anesthetized Wistar rats. Interventions:Rats received Escherichia coli lipopolysaccharide (1 mg/kg) and Staphylococcus aureus peptidoglycan (0.3 mg/kg) or vehicle intravenously. Insulin (1.4 units/kg intravenously) was administered in the absence or presence of continuous glucose administration (4.5 mg/kg/hr intravenously) either prophylactically or therapeutically. The potent and selective glycogen synthase kinase-3&bgr; inhibitor TDZD-8 (1 mg/kg intravenously) or vehicle (10% dimethyl sulfoxide) was administered either prophylactically or therapeutically. Measurements and Main Results:Coadministration of lipopolysaccharide and peptidoglycan resulted in increases in the serum levels of creatinine (indicator of renal dysfunction), alanine aminotransferase, and aspartate aminotransferase (indicators of liver injury) at 6 hrs. Insulin or TDZD-8 similarly attenuated the organ injury/dysfunction caused by lipopolysaccharide and peptidoglycan when given either prophylactically or therapeutically. Continuous glucose administration had no effect on blood glucose levels or organ injury/dysfunction at 6 hrs. Treatment with insulin or TDZD-8 reduced the plasma levels of the proinflammatory cytokine interleukin-1&bgr;. In vitro, insulin or TDZD-8 caused similar reductions in the nuclear factor-&kgr;B p65 activity and similar increases in the phosphorylation of Ser9 of glycogen synthase kinase-3&bgr;. Conclusions:Therapy with insulin or the potent and selective glycogen synthase kinase-3&bgr; inhibitor TDZD-8 reduced the organ injury/dysfunction caused by lipopolysaccharide and peptidoglycan in the rat. We propose that the inhibitory effect of insulin on the activity of glycogen synthase kinase-3&bgr; contributes to the protective effect of insulin against the organ injury/dysfunction caused by excessive systemic inflammation independently of any effects on blood glucose.
PREDATOR‐DRIVEN TRAIT DIVERSIFICATION IN A DRAGONFLY GENUS: COVARIATION IN BEHAVIORAL AND MORPHOLOGICAL ANTIPREDATOR DEFENSE

Proof for predation as an agent shaping evolutionary trait diversification is accumulating, however, our understanding how multiple antipredator traits covary due to phenotypic differentiation is still scarce. Species of the dragonfly genus Leucorrhinia underwent shifts from lakes with fish as top predators to fishless lakes with large dragonfly predators. This move to fishless lakes was accompanied by a partial loss and reduction of larval spines. Here, we show that Leucorrhinia also reduced burst swimming speed and its associated energy fuelling machinery, arginine kinase activity, when invading fishless lakes. This results in patterns of positive phylogenetic trait covariation between behavioral and morphological antipredator defense (trait cospecialization) and between behavioral antipredator defense and physiological machinery (trait codependence). Across species patterns of trait covariation between spine status, burst swimming speed and arginine kinase activity also matched findings within the phenotypically plastic L. dubia. Our results highlight the importance of predation as a factor affecting patterns of multiple trait covariation during phenotypic diversification.