Miracle-dz/UniFAR-FTUs huggingface dataset:
Component resolved diagnostics in allocation to specific 
immunotherapy

Identification of key alergen is vital for allocation to alergen immunotherapy. Molecular allergology (component resolved diagnostics – CRD) alows detailed molecular profiling of the polyclonal IgE in a particular patient. The use of molecular diagnostics in allergology improves sensitivity and specificity of diagnostic procedures, enables assessement of the prognosis and risk associated with a given type of sensitization and enables application of the most appropriate treatment, including qualification for specific immunotherapy. Diagnostic algorithms based on single or multiple molecular IgE tests, in contrast to diagnostic procedures based on alergen extracts, allow discrimination of genuine sensitization (sIgE against major allergens, markers of primary sensitization) from cross-reacting sensitization (sIgE against panallergens: profilins, polkalcins, tropomyosins). It has been hypotesized that patients without sensitization to major allergens may receive
Platformed Interactions: How Social Media Platforms Relate to Candidate–Constituent Interaction During Finnish 2015 Election Campaigning

Interaction between candidates and constituents via social media is a well-studied domain. The article takes this research further through a synthesis with platform studies, emerging scholarship that applies a critical perspective to the role of digital platforms in society. Examination of candidate–constituent interaction via Twitter and Facebook during the 2015 Finnish parliamentary elections revealed that the types of interaction differ between the two platforms: Facebook was used for formal campaigning and for praising and expressing support, while Twitter was utilized for information and for seeking and sharing opinions. An additional finding is that interaction approaches may be platform-specific, with socio-emotional functions being employed more often by candidates than constituents on Facebook while no such difference existed for Twitter. On the basis of the implication that platforms have a critical role in the nature of candidate–constituent social media interaction, we discuss the implications of platformed interaction for the democratic process, suggesting that campaign strategy may exploit it in ways that may even necessitate regulation. Furthermore, scholars of social media interaction might need to consider the broader ramifications of the findings, and contributions to theory that acknowledge platforms’ part in interaction may be needed.
Protein Microarray Analysis of Soluble Biomarkers in Fertile and Postmenopausal Women in Relation to Obesity, Bone Status and Blood Cell Populations

Objective: The purpose of the present study was to quantify serological biomarkers, namely adiponectin, leptin, E-selectin, ICAM-1 (intercelluar cell adhesion molecule-1), IGF-1 (insulin-like growth factor 1), MCSF (macrophage colony-stimulationg factor), IL-6, IL-10 and IL-17), in fertile and postmenopausal women. The relationship of these parameters to obesity and bone status has been analysed. Methods: 96 fertile and 107 postmenopausal women were enrolled in this study. The detection of multiple biomarkers, cytokines, growth factors, adhesion molecules and others, was performed by protein microarray. Results: Adipopnectin was up-regulated in postmenopausal control and ICAM-1 in postmenopausal obese women when compared to fertile obese women (p<0.05). Significant negative correlation was between IL-6 and age (r=-0.177, p<0.05). The soluble form of ICAM-1 was higher in women with osteopenia, but not with osteoporosis, in comparison to the control group. IL-6 was decreased in women affected by osteoporosis. Conclusion: In context to obesity, bone status and ageing, we have found alterations in adiponectin, ICAM-1, and IL-6 parameters in postmenopausal women. We identified several statistically significant correlations between soluble biomarkers and cell populations (e.g. between IGF-1 and B-lymphocytes; IL-6 and dendritic cells; IL-10 and naive T cells, etc.).
Abstract 5432: Discovery and characterization of USP22 inhibitors as novel anti-cancer agents

The degradation of most cellular proteins is regulated by coordinated addition and removal of ubiquitin by families of ubiquitin E3 ligases and deubiquitylating enzymes (DUBs) respectively. DUBs proteolytically cleave ubiquitin molecules from proteins resulting in modifications of protein activity, localization and function. Several DUBs are aberrantly regulated in cancer, including the best studied, USP7, selective inhibitors of which are active in cancer models. USP22, is another validated anticancer target, being one of 11 genes in the death-from-cancer gene signature, a component of the human SAGA transcriptional cofactor complex regulating myc transcription, and a regulator of the expression of p21, the histone deacetylase Sirt 1, and p53 activity. USP22 is overexpressed in oral squamous cell carcinoma, breast, non-small cell lung, colorectal, and other cancers and its expression is inversely correlated with survival. Unlike most other DUBs, USP22 exhibits robust activity only as a component of a multi-subunit complex. Initial studies reported activity solely as a member of the 2MDa SAGA complex, but more recently it has been demonstrated that USP22 exhibits similar activity in a four-protein DUB module derived from the SAGA complex. USP22 inhibitors are expected to have broad anti-cancer activities. Progenra9s UbiProTM discovery platform was utilized to screen ∼200K member diversity based library of small molecules for identifying novel USP22 inhibitors. Data will be presented describing these results. Citation Format: Feng Wang, Timothy R. Stanek, Leelabati Biswas, Matthew Kodrasov, James LaRocque, Jian Wu, David Sterner, Joseph Weinstock, Michael Mattern, Steven B. McMahon, Suresh Kumar. Discovery and characterization of USP22 inhibitors as novel anti-cancer agents. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5432. doi:10.1158/1538-7445.AM2015-5432
Marketing Analysis over Start-up Business in Lifestyle (Combining Barbershop and Coffee shop) at PT. Jeeva Work Corporation

The phenomenon of changing the hair style and coffee shop has become a part of our lifestyle. Business opportunities in both sectors are very large. In 2020, the barbershop market share is 52.65% or 74,921 people in the area of West Java, with a population of 142,300 inhabitants. PT. Jeeva Work Corporation is a private company in the Barbershop and coffee shop sector especially for men who are starting to try to be stylish and more aware of their appearance by choosing stylish hairstyles. The company takes advantage of this opportunity by establishing a premium barbershop business, which is provides technology to select hair models in the form of menus with a remodeling application and provides rapid registration technology by developing an online registration application, and equipped with coffee shop facilities under the brand of Jeeva Barber Coffee.
Evaluate the ability of Syntaxin genes to enhance resistance against Fusarium virguliforme and Heterodera glycines

Soybean sudden death syndrome (SDS) caused by Fusarium virguliforme is a common and widespread disease across soybean-growing regions worldwide. Experiments were conducted in temperature-controlled water baths in the greenhouse to test the effects of some genes from syntaxin group (SYP22-3 and SYP22-4) on F.virguliforme and the combination of SDS and soybean cyst nematode (Heterodera glycines). Both genes were tested in different combinations with currently two pathogens to examine their ability to manage studied pathogens. Syntaxin evaluated on soybean seedlings infected with F. virguliforme alone and both F. virguliforme and H. glycines. Results showed that there were significant effects of syntaxin genes to reduce the foliar disease severity on soybean plants. Furthermore, they reduced the number of H. glycines females cysts compared to control. Data analysis did not show any negative effect by syntaxin genes on plant growth.
Analysis of Prediction of Current Profit and Interval Fuzzy Profit in the Case of Subsidized Projects

The analysis aims at the prediction of the present value of profit from investment in subsidized renewable energy production operating under condition of uncertainty stemming from a priory ignorance on the input side. The state of such uncertainty does not provide the analyst with any objective evidence to construct a rational estimate. The prediction procedures should, therefore, be based on intervals of possible input values. This basic principle is derived from the fact that in terms of such uncertainty there is a better chance to correctly define the intervals in which priori expected inputs are found than to correctly predict a single value. This argument is developed in the methodology, in which the formula for quantifying the profit present value is translated from the language of the arithmetic into the corresponding formula of the interval language. In the application part, the biogas station is a specific representative of the system operating under conditions of mentioned uncertainty on the input side. Significant interval profit points compared to the spot value of current profit provide information about the degree of safety of the investment in terms of its resistance to possible loss; this conclusion is the main original superstructure of the paper.
Girassol suplementado com percolado de aterro sanitário e submetido à salinidade

O percolado de aterro sanitário é um líquido produzido a partir de processos físicos, químicos e biológicos aos quais os resíduos sólidos urbanos são submetidos nos aterros sanitários. Apresenta uma composição físico-química variável e pode conter altos teores de nutrientes, sendo assim empregado na fertilização de plantas. Por isso, objetivou-se avaliar o crescimento de plantas de girassol irrigadas com água de moderada salinidade e com suplementação nutricional com percolado de aterro sanitário. O experimento foi conduzido em área experimental com cobertura de nylon (sombrite), sob delineamento inteiramente casualizado em um fatorial 4 x 2, sendo [1: 100% de areia de granulometria fina - NBR 6502; 2: areia + adubo/fertilizante orgânico misto (mistura de bagaço de cana, esterco bovino, esterco de galinha, serragem de madeira e gesso agrícola) e 80 kg de N ha-1, 3: areia + percolado de aterro sanitário e 80 kg de N ha-1; e 4: areia + percolado de aterro sanitário e 160 kg de N ha-1] e duas concentrações salinas da água de irrigação [irrigação com água destilada ou solução de NaCl a 60 mM], com 10 repetições, em vasos de 12 L. Foram realizadas análises de crescimento (altura, diâmetro do coleto, número de folhas), teores relativos de clorofila e diâmetro dos capítulos. Nas condições experimentais empregadas, substrato arenoso, as concentrações de percolado de aterro sanitário utilizadas promoveram incrementos em todas as variáveis de crescimento analisadas nas plântulas de girassol, especialmente a 80 Kg N ha-1. A irrigação com solução de NaCl a 60 mM não ocasionou efeitos negativos nas variáveis de crescimento, demonstrando assim a tolerância moderada das plantas de girassol à salinidade em substrato arenoso.
High-performance plasmas after pellet injections in Wendelstein 7-X

A significant improvement of plasma parameters in the optimized stellarator W7-X is found after injections of frozen hydrogen pellets. The ion temperature in the post-pellet phase exceeds 3 keV with 5 MW of electron heating and the global energy confinement time surpasses the empirical ISS04-scaling. The plasma parameters realized in such experiments are significantly above those in comparable gas-fuelled discharges. In this paper, we present details of these pellet experiments and discuss the main plasma properties during the enhanced confinement phases. Local power balance is applied to show that the heat transport in post-pellet phases is close to the neoclassical level for the ion channel and is about a factor of two above that level for the combined losses. In comparable gas-fuelled discharges, the heat transport is by about ten times larger than the neoclassical level, and thus is largely anomalous. It is further observed that the improvement in the transport is related to the peaked density profiles that lead to a stabilization of the ion-scale turbulence.
ALTIN, HAM PETROL, GVZ VE OVX’İN TÜRK FİNANSAL PİYASALARINA SİMETRİK VE ASİMETRİK ETKİLERİ

Piyasalar arasi etkilesimleri ve asimetrik nedensellik iliskilerini inceleyen bu calismada BIST100 getirileri ile Dolar/TL kuru, Altin, Ham Petrol, Altin Oynaklik Endeksi (GVZ) ve Ham Petrol Oynaklik Endeksi (OVX) getirileri arasindaki ikili iliskiler arastirilmistir. Calismada, Dogrusal Granger Nedensellik Testi, Hiemstra ve Jones Dogrusal Olmayan Nedensellik Testi, Kyrtsou ve Labys Dogrusal Olmayan Nedensellik Testi ve Hristu-Varsakelis ve Kyrtsou Dogrusal Olmayan Asimetrik Nedensellik testleri uygulanarak iliskilerin varligi ve yonu incelenmistir. Analizlerde, 01.01. 2010 ile 01.01. 2018 donemlerini kapsayan 2332 adet gunluk fiyat serisi kullanilmistir. Elde edilen bulgulara gore BIST100 ile bahsi gecen seriler arasinda cesitli simetrik ve asimetrik nedensellik iliskisine rastlanilmistir. http://dx.doi. org/10.17130/ijmeb.2019355047
Novel approach to distinguish between vacuum UV-induced ice photodesorption and photoconversion

Context. In cold regions of the interstellar medium with intense ultraviolet radiation fields, photodesorption has been suggested as a nonthermal desorption mechanism promoting the transition of molecules from the solid state to the gas phase. Laboratory experiments measuring photodesorption rates are crucial in attempting to explain high molecular gas phase abundances of species that are expected to form in the solid state, such as methane, methanol, and acetonitrile, and to aid astrochemical modeling. Due to the convoluted competition between photodesorption and photoconversion, it is far from trivial to derive accurate photodesorption rates. Aims. The aim of this study is to apply a new methodology to discriminate between the two processes. The method has been validated using the well-studied case of CO and extended to CH4, CH3OH, and CH3CN. Methods. Vacuum ultraviolet (VUV; photon energy of 7–10.2 eV) irradiated ices at 20 K are studied, first as a pure CH4, CH3OH, or CH3CN ice and subsequently with an Ar coating on top. The latter is transparent to the VUV photons (wavelength below 200 nm), but it quenches the photodesorption process. Comparing the laser desorption post ionization time-of-flight mass spectrometry of the ices with and without the Ar coating provides information on the different interactions of the VUV photons with the ice. Results. The newly developed experimental technique allowed for a derivation of photodesorption rates for ices at 20 K of: CO (3.1±0.3)×10−3 mol. photon−1, CH4 (3.1±0.5)×10−2 mol. photon−1, and upper limits for CH3OH (<6×10−5 mol. photon−1) and CH3CN (<7.4 × 10−4 mol. photon−1); in the latter case, no literature values have been reported yet. The newly introduced approach provides more insight into the photodesorption process, in particular, for commonly observed complex organic molecules (COMs). Photoconversion cross sections are presented in the 7–10.2 eV range. The possible role of photodesorption and photoconversion in the formation of interstellar COMs is discussed.
Virtual user pairing based non-orthogonal multiple access in downlink coordinated multipoint transmissions

In this study, joint transmission coordinated multi-point (JT-CoMP) is integrated with virtual user pairing based non-orthogonal multiple access (VP-NOMA), termed as JT-CoMP VP-NOMA. JT-CoMP is a multi-cell coordination scheme, where base stations of neighbouring cells coordinate with each other to improve the performance of their common cell edge users (CEUs). On the other hand, VP-NOMA is a one-to-many user pairing scheme in non-orthogonal multiple access (NOMA), where one cell centre user (CCU) within a cell can be paired/multiplexed with multiple CEUs for better spectrum utilisation. The proposed scheme combines both VP-NOMA for enhancing ergodic sum capacity (ESC) within a cell and JT-CoMP for mitigating inter-cell interference (ICI) between neighbouring cells. To demonstrate the achieved performance gains, ESC of a three-cell scenario is analysed as a key performance metric, where each cell contains two users; a CCU and a CEU. Closed-form expressions for ESC of the considered system are derived, and validated through simulations. Furthermore, the analytical and simulation results of JT-CoMP VP-NOMA are compared with orthogonal multiple access, NOMA, and VP-NOMA to show the achieved performance gains. It is shown that the proposed JT-CoMP VP-NOMA outperforms the other schemes in the viewpoint of ESC.
Clinical and genetic aspects of Marfan syndrome and familial thoracic aortic aneurysms and dissections

This thesis concerns the clinical and genetic aspects of familial thoracic aortic aneurysms and dissections, in particular in Marfan syndrome. It includes the Dutch multidisciplinary guidelines for diagnosis and management of Marfan syndrome. These guidelines contain practical directions for referring physicians and specialists involved in the recognition, diagnosis, monitoring and treatment of Marfan syndrome. Furthermore, the revised Ghent nosology for Marfan syndrome, established by an international panel of experts, is presented. One chapter concerns a specific subgroup of missense mutations in FBN1 that are predicted to substitute the first aspartic acid of various calcium-binding Epidermal Growth Factor-like (cbEGF) fibrillin-1 domains. One of the mutations was found in a homozygous state in three cases from a large consanguineous family. A series of ten patients carrying a whole-gene deletion of one allele of FBN1 is described in another chapter. In a further chapter a three-generational family is discussed with family members at risk for serious aortic disease as a result of an interstitial deletion of chromosome 15 that disrupts SMAD3. Finally two unrelated children with classic Marfan syndrome and recurrent intracranial hypertension are described.
Wild Mammal Translocations: A Public Health Concern

With regard to wildlife translocations and the assessment of potential risk of disease transmission, several advances have been made in conservative projects. However, other factors like the large number of species received at screening centers from different locations, rescued after being hit by vehicles, taken by the public or confiscated from illegal trade by the authorities, have increased the risk of spreading, emergence or reemergence of zoonosis. Besides the notorious importance of the procedure improvement for managing wildlife, the access to as much as possible information about the occurrence of potential infections on each particular species can be a tool of great value for mitigating the disease risk. In the present paper, it was showed the evolution of processes for wildlife translocations mostly related to mammals, we also discussed some aspects related to sylvatic animals as reservoir host of zoonosis and finally were presented several tables recording numerous mammals hosts and their respective parasitic protozoa.
Preparation and characterization of CdWO4:Cu nanorods with enhanced photocatalytic performance under sunlight irradiation

The objective of this work is to convert an ultraviolet active photocatalyst to a visible active photocatalyst and investigate the effect of copper (Cu2+) doping on the morphology and photocatalytic activity of CdWO4. Efficient visible light driven Cu2+ doped CdWO4 photocatalysts were successfully prepared by a hydrothermal method and characterized by various techniques. The XRD results revealed that CdWO4 and Cu2+ doped CdWO4 have crystallized in a monoclinic wolframite structure. The SEM images displayed nano rod like morphology and as the Cu2+ content is increased irregular structures were observed. The best photocatalytic activity was observed for Cd0.95Cu0. 05WO4 in the presence of H2O2 under sunlight irradiation and it was found to be 5 times more than that of pristine CdWO4. The enhanced photocatalytic activity of the Cu2+ doped CdWO4 compositions leads to further improvement of the catalysts for environmental remediation.
Fibroblast growth factor-2 prevents synaptic pathology in minimal hepatic encephalopathy via NRG1/ErbB4 signaling

Background Minimal hepatic encephalopathy (MHE) is implicated in the impairment of memory function. Fibroblast growth factor-2 (FGF2) is involved in modulating synaptic and neuronal formation. Methods The aim of this study is to examined the impacts of FGF2 on MHE pathology. Our study addressed whether FGF2 could trigger neuregulin-1 (NRG1) release to ameliorate synaptic impairment in MHE rats and in primary cultured neurons. Results The results showed the decreased FGF2 expression in MHE brains. After treatment with FGF2, secreted neuregulin-1 (NRG1) and ErbB4 were increased, and the interaction of the 2 proteins was enhanced. Additionally, treatment with FGF2 or NRG1 induced synaptic formation, with increase in the activity of synapse and the density of dendritic spine, through Sirt1. NRG1 signaling was prevented by administration of FGF2, which acts through the FGFR1 in MHE rats. Finally, intracerebroventricular injection with FGF2 or NRG1 mitigated the impairment of synaptogenesis. Conclusion The data suggest that FGF2 may be a promising latent therapeutic reagent for MHE pathogenesis.
A Compact Multiband Quasi-Optical System for Plasma Detection

With the increased plasma frequencies, millimeter wave diagnose of plasma over a broadband range is technically preferred. This article describes the design, fabrication, and measurement of a compact triband quasi-optical system covering 33–110 GHz for the EAST tokamak plasma detection. The overall size of the quasi-optical system is 300 mm by 300 mm. Two broadband frequency selective surfaces are implemented with patch-grid structure to separate the signal to the <inline-formula> <tex-math notation="LaTeX">$Q$ </tex-math></inline-formula>-band, <inline-formula> <tex-math notation="LaTeX">$V$ </tex-math></inline-formula>-band, and <inline-formula> <tex-math notation="LaTeX">$W$ </tex-math></inline-formula>-band. A trade-off is made between the selectivity and bandwidth. Horn antennas are designed based on a multiflare structure to produce good Gaussian beam radiation. The measured results agree well with the simulated ones. The overall transmission loss of the whole system is better than 3 dB in the <inline-formula> <tex-math notation="LaTeX">$Q$ </tex-math></inline-formula>-band and <inline-formula> <tex-math notation="LaTeX">$V$ </tex-math></inline-formula>-band, and it is better than 7 dB in the <inline-formula> <tex-math notation="LaTeX">$W$ </tex-math></inline-formula>-band. The system has been deployed on EAST tokamak for real-time plasma detection.