Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of scheduled qigong exercise on pupils' well-being, self-image, distress, and stress.

OBJECTIVES Psychologic problems is increasing among pupils and has become a major problem in Sweden as well as in other Western countries. The aim of this study was to explore whether scheduled qigong exercise could have an effect on well-being at school, psychologic distress, self-image, and general stress. SUBJECTS Pupils, 13-14 years, were assigned to either a qigong group or a control group. INTERVENTION The qigong group had scheduled qigong 2 times a week for 8 weeks. MEASURES Self-reported well-being at school, psychologic distress, self-image, and stress were measured pre- and postintervention. RESULTS The control group had reduced well-being at school during the semester and the qigong group was stable. The qigong group reduced psychologic distress and stress, and had a tendency to improved self-image, whereas no changes were found in the control group. Self-image explains 47% (R(2) = 0.47) of well-being at school, and stress explains 29% (R(2) = 0.29) of psychologic distress. CONCLUSIONS Scheduled qigong, meditative movement, is a possible way to improve well-being at school.
Prognostic clinicopathologic factors, including immunologic expression in diffuse large B‐cell lymphomas

The aim of this study was to assess the clinical significance and potential prognostic value of the expression of a panel of surface markers, proliferating, suppressor and oncogenic proteins in diffuse large B‐cell lymphomas (DLBCL). Biopsies were collected from 158 patients with DLBCL and analyzed immunohistochemically for p53, p21/WAF1, bcl‐2, cyclin‐D1, bcl‐6, mdr, CD5, CD30, epithelial membrane antigen (EMA), Ki‐67 and c‐myc positive tumor cells. Among these, 76 young and middle‐aged patients (20–65 years) were selected to investigate the relationship between protein expression, clinical features, and survival. Survival analysis showed that advanced stage, high lactic dehydrogenase level, and high International Prognostic Index (IPI) were poor prognostic factors associated with a shorter overall survival (OS) and disease‐free survival (DFS) times. A high p53 expression and low bcl‐6 expression were associated with a shorter DFS time. The histological variant type, cyclin‐D1+ CD5+ DLBCL, positive epithelial membrane antigen (EMA+) CD30– DLBCL, high bcl‐2 expression, and low Ki‐67 proliferation activity tended to be associated with worse survival, but the correlations were not statistically significant. In the multivariate analysis, the most significant factors were age, followed by IPI and last p53. The expression of p21/WAF1, mdr, and c‐myc proteins did not influence OS and DFS. The expression of p53 and bcl‐6 proteins may be useful prognostic indicators in DLBCL. Cyclin‐D1+ CD5+ or EMA+ CD30– DLBCL tended to predict a worse survival and may probably bear a significant prognostic value worthy of consideration. Overall, clinical factors appeared to be more important than biologic parameters in determining the prognosis of diffuse large B‐cell lymphomas.
Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients

Cisplatin reduces plasma ghrelin levels through the 5‐hydroxytryptamine (5‐HT) receptor. This may cause cisplatin‐induced gastrointestinal disorders and hinders the continuation of chemotherapy. The authors of this report conducted a prospective, randomized phase 2 trial to evaluate the effects of exogenous ghrelin during cisplatin‐based chemotherapy.
Lower Digestive Tract Microbiology

The lower digestive tract of animals is often referred to as the hindgut and normally denotes the large intestine, which includes the cecum, colon, and rectum. The cecum is a branch from the junction of the small intestine and colon. There is a great diversity among animals in hindgut morphology, mainly in relation to diet of the animal. Carnivores have a small hindgut and a cecum may be absent. However, herbivores, such as the horse, have a large hindgut capacity. The hindgut of nonruminant animals is the primary site for retention of food residues and endogenous substrates for microbial fermentation. Conditions in the hindgut include a constant temperature, pH between 6.5 and 7.5, and low concentrations of oxygen, thus providing an environment for 10 to 10 microorganisms of up to 400 different species per gram of lumen contents. The fermentation end products of the microorganisms—short-chain volatile fatty acids, primarily acetate, propionate, and butyrate—are absorbed throughout the hindgut and used as energy by the animal. Humans have continuously tried to influence the microbial species present in the intestinal tract with the objective to increase meat-animal production efficiency. This has occurred primarily with the use of antibiotics, prebiotics, probiotics, or other dietary additives.
Management of reflux disease

The management of reflux disease can be divided into three major phases, the first being diagnosis and severity assessment, the second, prompt initial control of symptoms, and the third, selection of a long term management approach that is tailored to meet individual patient needs and preferences. Throughout these phases of management, the major priorities should include achieving patient satisfaction and minimising management costs.
Arterial Spin-Labeling in Routine Clinical Practice, Part 2: Hypoperfusion Patterns

SUMMARY: Arterial spin-labeling (ASL) is a powerful perfusion imaging technique capable of quickly demonstrating both hypo- and hyperperfusion on a global or localized scale in a wide range of disease states. Knowledge of pathophysiologic changes in blood flow and common artifacts inherent to the sequence allows accurate interpretation of ASL when performed as part of a routine clinical imaging protocol. Patterns of hypoperfusion encountered during routine application of ASL perfusion imaging in a large clinical population have not been described. The objective of this review article is to illustrate our experience with a heterogeneous collection of ASL perfusion cases and describe patterns of hypoperfusion. During a period of 1 year, more than 3000 pulsed ASL procedures were performed as a component of routine clinical brain MR imaging evaluation at both 1.5 and 3T. These images were reviewed with respect to image quality and patterns of hypoperfusion in various normal and disease states.
Susceptibility of Cell Populations to Transduction by Retroviral Vectors

ABSTRACT Retroviral transduction efficiency is related to the multiplicity of infection and the physiological state of the target cells. It is generally not known what proportion of a cell population is susceptible to transduction. We used coinfection with two retroviral vectors containing the marker genes for green fluorescent protein and the truncated human nerve growth factor receptor. In the CD34+ cell line TF-1 or human primary CD34+ hematopoietic progenitor cells, it was found that cells transduced with one vector had a better than random chance of transduction by the other vector. A probability model was developed to estimate target cell susceptibility; susceptibility was calculated as the product of the proportions of transgene-positive cells divided by the proportion of double-positive cells. By using this relationship, it was found that susceptibility was related to the target cell type and culture conditions but not the retroviral titer or the retroviral packaging envelope protein used in this study. Cotransduction with two vectors is a relatively simple procedure that provides a means to assess the maximum transduction level possible in a given cell population.
Full-Custom Design Fractional Step-Down Charge Pump DC-DC Converter with Digital Control Implemented in 90nm CMOS Technology

A full-custom design fractional step-down charge pump DC-DC converter with digital control is proposed, design and simulated in 90nm 1P9M CMOS process technology. This paper aimed to design a simple and small solution size implementation of DC-DC converter with fast settling time response and low ripple output voltage implementation while not compromising efficiency requirement. Moreover, this converter can operate at internally fixed 1 MHz with input voltage from 2.2V to 3.3V suitable for two batteries power applications. The converter is design to have an output voltage of 1.1V with load current requirement of greater than 10mA, a ripple voltage less than l0mV and a faster settling time of 82.9 µs. The peak efficiency is over 75%. 
MM: Modular architecture for multimedia information retrieval

In this paper we present an overview of a modular architecture that provides a set of tools used to analyze, index and retrieve multimedia documents. It addresses the users communities interested into multimedia document indexing and retrieval, filtering and mining, especially when the interaction between heterogeneous data are of interest (multi-modal and cross-modal indexing). The objective of the full architecture is to index and retrieve heterogeneous multimedia documents containing texts, audio and still or moving images based on user query. This query may be a simple text, a more complex and structured query or an example of multimedia document. The modular aspect of our system allows to configure it according to the needs. Main features of the system are reviewed then a walk-through of the demo is presented.
Integration of Structured Biological Data Sources using Biological Expression Language

Background The integration of heterogeneous, multiscale, and multimodal knowledge and data has become a common prerequisite for joint analysis to unravel the mechanisms and aetiologies of complex diseases. Because of its unique ability to capture this variety, Biological Expression Language (BEL) is well suited to be further used as a platform for semantic integration and harmonization in networks and systems biology. Results We have developed numerous independent packages capable of downloading, structuring, and serializing various biological data sources to BEL. Each Bio2BEL package is implemented in the Python programming language and distributed through GitHub (https://github.com/bio2bel) and PyPI. Conclusions The philosophy of Bio2BEL encourages reproducibility, accessibility, and democratization of biological databases. We present several applications of Bio2BEL packages including their ability to support the curation of pathway mappings, integration of pathway databases, and machine learning applications. Tweet A suite of independent Python packages for downloading, parsing, warehousing, and converting multi-modal and multi-scale biological databases to Biological Expression Language
Exploring the Correlates of Intermediate CAG Repeats in Huntington Disease

Abstract Objective: To explore the clinical phenotype in individuals with huntingtin gene CAG repeat lengths between 27 and 35, a range that is termed “intermediate” and below one traditionally considered diagnostic of Huntington disease (HD). Background: The Prospective Huntington Disease At-Risk Observational Study (PHAROS) found that patients with intermediate CAG lengths overlapped with those diagnosed as HD (≤ 37 CAG repeats) on the Unified Huntington's Disease Rating Scale (UHDRS) behavioral measures. Furthermore, several patients with intermediate CAG repeats demonstrating clinical (and pathological) evidence of HD have been reported. Methods: We reviewed all cases with intermediate CAG repeats who have presented to our clinic, as well as those reported in the literature. Results: We describe 4 patients with intermediate repeats evaluated at our center whose clinical features were highly suggestive of HD. Investigations for HD phenocopies were negative. Anticipation was demonstrated in 1 case with supportive neuropathological evidence of HD. Additionally, we describe the clinical features of 5 other patients reported in the literature. Conclusion: Individuals with huntingtin gene CAG repeats in the intermediate (27-35) range should be considered at risk for the development of HD, particularly if they have a family history of HD, whether they exhibit clinical features of the disease.
Service Quality in Hospitals: More Favourable than You Might Think

This paper examines and measures the quality of services provided by private hospitals in Malaysia. Empirical research is used to determine patients’ expectations and perceptions of the quality of service, and a comprehensive scale adapted from SERVQUAL is empirically evaluated for its usefulness in the Malaysian hospital environment. Results based on testing the mean differences between expectations and perception indicate that patients’ perceived value of the services exceed expectations for all the variables measured. A comparative analysis with similar studies in other regions is reported, and the implications are discussed.
Impersonating Myself on the Internet

This paper describes the implementation of a computer program that responds to chat messages sent by users of an internet chat client. The program uses a statistical model of previous chat messages sent and received by the author to determine possible meanings of incoming messages and select an appropriate response. Two heuristics are also used to allow the program to respond in cases where the meaning of a message is unclear.
Identification and characterization of calcifying valve cells from human and canine aortic valves.

BACKGROUND AND AIM OF THE STUDY Cardiac valve calcification is the predominant pathology in patients needing valve replacement. The aim of this study was to determine if aortic valve cells calcify spontaneously and, if so, to characterize the nodular complex and response to growth factors. METHODS Aortic valves were obtained from humans undergoing surgical valve replacement, and from female dogs. The valvular endothelium was removed and explants cultured in medium. RESULTS A population of valvular interstitial cells spontaneously formed distinct calcified nodules containing hydroxyapatite within two to three weeks in canine and within six weeks in human aortic valves. The nodules contained an inner ring of dead cells surrounded by an outer ring of living cells. Cells associated with nodules had osteoblast-like characteristics and stained positively for extracellular bone matrix proteins. Incubating canine cells with potential calcifying stimuli tested the stimulus for calcification. The rate of nodule formation was increased with transforming growth factor beta-1 (+25 nodules), 25-hydroxycholesterol (+9 nodules) and bone morphogenetic protein 2 (+4 nodules) as compared with vehicle control (+3 nodules) over 25 days. CONCLUSIONS We identified a population of valvular interstitial cells with osteoblast-like characteristics that spontaneously form calcific nodules in cell culture. In addition, the rate of calcific nodule formation was increased with transforming growth factor beta-1 and 25-hydroxycholesterol. Further study of these 'calcifying valve cells' may yield a new in vitro model for testing therapy aimed at preventing calcific valve stenosis.
Compromised Survivorship in Zoo Elephants

We analyzed data from over 4500 elephants to show that animals in European zoos have about half the median life span of conspecifics in protected populations in range countries. This discrepancy is clearest in Asian elephants; unlike African elephants in zoos, this species' infant mortality is very high (for example, twice that seen in Burmese timber camps), and its adult survivorship in zoos has not improved significantly in recent years. One risk factor for Asian zoo elephants is being moved between institutions, with early removal from the mother tending to have additional adverse effects. Another risk factor is being born into a zoo rather than being imported from the wild, with poor adult survivorship in zoo-born Asians apparently being conferred prenatally or in early infancy. We suggest stress and/or obesity as likely causes of zoo elephants' compromised survivorship.
SentiHealth-Cancer: uma ferramenta de análise de sentimento para ajudar a detectar o humor de pacientes de câncer em uma rede social online

O câncer e uma doenca critica que afeta milhoes de pessoas e familias em todo o mundo. Em 2012, cerca de 14,1 milhoes de novos casos de câncer ocorreram no mundo. Devido a muitas razoes, como a gravidade de alguns casos, os efeitos colaterais de alguns tratamentos e morte de alguns pacientes, pessoas com câncer tendem a ser afetados por graves disturbios emocionais, por exemplo, a depressao. Assim, o uso de uma ferramenta comportamental que auxilie a deteccao do humor das pessoas pode contribuir para o acompanhamento de pacientes e familiares durante o tratamento. Portanto, o objetivo deste trabalho e desenvolver uma ferramenta de Analise de Sentimento, chamada SentiHealth-Cancer (SHC), para auxiliar a deteccao do estado emocional de pessoas membros de comunidades virtuais brasileiras de apoio a pacientes de câncer. Foi realizado um estudo comparativo entre a ferramenta proposta e outras quatro de ferramentas de proposito geral de Analise de Sentimento. Para isso, foram coletadas 789 mensagens de 8 comunidades do Facebook e consideradas 2.574 avaliacoes de voluntarios sobre os sentimentos reais expressos nessas mensagens. Com isso, foram testados os desempenhos das ferramentas em cada comunidade, com avaliacoes de psicologos e nao psicologos e, quando possivel, com textos em portugues e traduzidos para o ingles. Os resultados demonstraram que, no geral, o desempenho do metodo proposto neste trabalho e superior as outras ferramentas, tanto elas analisando textos em portugues quanto em ingles. Por exemplo, sua acuracia (56.64%) analisando todas as mensagens apresenta um aumento significativo de 11.78% em relacao a maior acuracia (50.67%) apresentada pelas outras ferramentas.
Design and development of novel control strategy for trajectory tracking of mobile robot: Featured with tracking error minimization

In this paper, trajectory control of the mobile robot is implemented to minimise the trajectory tracking error. It was found that there is a challenging task to orient the robot for any trajectory path to be traced. A novel control strategy for two wheel drive robot is proposed to trace the path of a given trajectory. The control algorithm developed for differential drive robot to track trajectory is composed of Lyapunov controller and least mean square algorithm as an observer. The proposed control law for the kinematic model of a differential drive robot resulted in minimized trajectory tracking error. Also, the linear and non-linear trajectories can be tracked using the proposed control strategy.
[HBV infection downregulated Mre11 expression and induced genome instability].

OBJECTIVE Prolonged infection with Hepatitis B virus (HBV) has been recognized as a major factor for hepatocellular carcinoma (HCC). In this study, we studied the host protein Mrel11 fluctuations after HBV infection which might be eventually contributed to cell transformation. METHODS Western Blot was monitored to detect the expression of Mre11, and RNA interference was used to downregulate protein expression. Then, Ligation mediated PCR was used to detect the level of DNA double strand breaks. RESULTS Mre11 protein was downregulated when HBV infection occured, and the downregulated expression was also seen in HCC tissue. By RNA interference, we found that Mre11 knockdown caused DNA instability. CONCLUSION Mre11 expression downregulation contributed at least partially to cell transformation caused by HBV infection.
A High-Frequency Transconductance Method for Characterization of High- $\kappa$ Border Traps in III-V MOSFETs

A novel method that reveals the spatial distribution of border traps in III-V metal-oxide-semiconductor field-effect transistors (MOSFETs) is presented. The increase in transconductance with frequency is explored in a very wide frequency range (1 Hz-70 GHz) and a distributed RC network is used to model the oxide and trap capacitances. An evaluation of vertical InAs nanowire MOSFETs and surface-channel InGaAs MOSFETs with Al<sub>2</sub>O<sub>3</sub>/HfO<sub>2</sub> high-κ gate dielectric shows a deep border-trap density of about 10<sup>20</sup>cm<sup>-3</sup>eV<sup>-1</sup> and a near-interfacial trap density of about 10<sup>21</sup>cm<sup>-3</sup>eV<sup>-1</sup>. The latter causes an almost steplike increase in transconductance at 1-10 GHz. This demonstrates the importance of high-frequency characterization of high-κ dielectrics in III-V MOSFETs.
Exercise Training and Antioxidants: Relief from Oxidative Stress and Insulin Resistance

HENRIKSEN, E. J., and V. SAENGSIRISUWAN. Exercise training and antioxidants: Relief from oxidative stress and insulin resistance. Exerc. Sport Sci. Rev., Vol. 31, No. 2, pp. 79–84, 2003. There is evidence for an association between oxidative stress and insulin resistance, possibly due to downregulation of insulin signaling. This review will address the hypothesis that exercise training and the antioxidant R-(+)-lipoic acid interact at the level of insulin signaling to enhance glucose transport in insulin-resistant skeletal muscle.
[Workers' Food Program: local managers' social representations].

OBJECTIVE To assess local managers' knowledge and social representations of a healthy diet and health promotion in the Workers' Food Program. METHODS A cross-sectional study was carried out with companies registered in the Workers' Food Program in the city of São Paulo, Southeastern Brazil. Semi-structured questionnaires were administered to local managers involved with workers' food. Data were tabulated through the Discourse of the Collective Subject using three methodological approaches: central idea, key expressions and discourse of the collective subject. RESULTS Discourses of managers from 70 companies were evaluated, indicating that 60% of central ideas expressed unfamiliarity on the Workers' Food Program and its objectives, or had as representation the benefits for their companies. However, it was observed that the most common central idea was: "It is a program to provide a balanced diet to workers", representing a discourse emphasizing a healthy diet and health promotion, which is close to Program's objectives. CONCLUSIONS The majority of discourses did not emphasize a healthy diet and health promotion. Thus for accomplishing the Program's objectives, local managers need to be familiar with Workers' Food Program and aware of its objective of health promotion.
Low profile high gain helix antenna over a conical ground plane for UHF RFID applications

This paper presents the design of a compact high gain circularly polarized antenna for UHF Radio Frequency Identification (RFID) reader covering the global band 860-960 MHz. The antenna is composed of an axial mode helix mounted on truncated cone ground plane. The optimized structure has a total size of 800×800×300mm3 and delivers maximum gain of 16 dBic, standing wave ratio <;2 and axial ration <; 2dB in the 100 MHz of bandwidth.
Single Trap Characterization in 50nm MOS Transistors by Charge Pumping Measurements

In this paper, we analyse the presence of individual traps located at the SiO2/Si interface of deep submicron MOS transistors (50 nm length) by charge pumping (CP) measurements. Theoretical and experimental results demonstrate the validity of the SRH statistics for the single traps activity. By changing the charge pumping parameters (rise and fall time, up and down time, reverse bias of the source and drain), we show that it is possible to identify the type of traps (acceptor or donor) and their spatial localisation along the SiO2/Si interface. The knowledge of the trap energy level allows the estimation of its capture cross section.