Miracle-dz/UniFAR-FTUs huggingface dataset:
P32 Pre-go-live simulation testing of new electronic prescribing systems in a specialist paediatric hospital

Aim Single-site cross-sectional evaluation of a specialist paediatric hospital electronic clinical systems designed to support the medication process. This included simulation testing and evaluation of three electronic systems: PICS an electronic prescribing system designed in an adult hospital and being adapted for paediatric use; BDD an in-development electronic drug dictionary database that will serve as a clinical decision support tool; and Ascribe the existing pharmacy dispensing and management system (used to provide target levels). Simulation testing is used to assess the utility of the systems in the local (paediatric hospital) setting and gauge readiness for use in the live environment. Methods Unique drug regimens from consecutive hand written outpatient pharmacy prescriptions and the hepatology ward paper drug charts were harvested and used as the simulation test. Each regimen was therefore in current use at the study site. The test prescriptions were used to identify each systems’ ability to accommodate that regimen, such that: PICS (electronic prescribing system) – can the regimens be prescribed on PICS? BDD (drug dosing database) – are these regimens held within the database? Ascribe (hospital pharmacy system) – can the regimens be recorded on Ascribe to facilitate medication supply? The system tests were undertaken in early July 2015 following suitable training on how to use each of the three systems. Trained researchers attempted to enter the regimens into PICs and Ascribe; and to identify if the regimens were available within the BDD database. Approval was granted by the study site, and Aston University Ethics Committee. Results Outpatients (89 unique regimens) PICS: 74% (66/89) of drug regimens could be completely reproduced electronically, with 34% (30/89) matching default dosing regimens. BDD: 40% (36/89) of drug regimens were found in the database (drug name, indication, route and dose in relation to the age of patient) Ascribe: 77.5% (69/89) of drug regimens were reproducible and had labelling templates that existed on the system, a further 17% (15/89) drug regimens were available but required some amendment to existing templates. Hepatology ward – (126 unique regimens) PICS: 71% (90/126) could be prescribed as written on the drug charts. BDD: 58% (73/126) of drug regimens were found in the database (drug name, route and dose in relation to the age of patient) Ascribe: 94% (118/126) of drug regimens were reproducible and had labelling templates that existed on the ascribe system, a further 18% (23/126) drug regimens were available but required some amendment to existing templates. Conclusion Overall, at the time of testing, the electronic prescribing system (PICS) could accommodate approximately 72% of drug regimens, the BDD database could accommodate approximately 51% – compared to the Ascribe (target figure) of 87%. The findings suggest that further work is required to ensure the systems in development (PICS and BDD) are ready for use.
As opções terapêuticas para os aneurismas fusiformes

Resumo Os aneurismas fusiformes são pouco frequentes e geralmente não estão associados a fatores de risco específicos. Ocorrem principalmente nas artérias cerebrais, por meio de uma dilatação circunferencial na parede da artéria, garantindo seu aspecto morfológico típico: ausência de colo aneurismático. Por essa razão, não podem ser usualmente clipados ou embolizados, necessitando de métodos alternativos de tratamento que representam um desafio para os neurocirurgiões. As alternativas cirúrgicas estão associadas a um melhor prognóstico e incluem as técnicas de revascularização com o uso de bypass, a oclusão da artéria aferente (PAO, sigla em inglês) e “wrapping” ou clip-wrap. Métodos endovasculares, como o uso de stents, representam uma opção para restauração mais fisiológica do fluxo sanguíneo, embora necessitem de mais estudos para confirmar a eficácia.
Relationships of Selected CYP and ABCB1 Single Nucleotide Polymorphisms and Patient Characteristics with the Pharmacokinetics of Twice Daily Tacrolimus and Advagraf® in Renal Transplant Recipients

Page 4 of 377 Abstract Tacrolimus is one of the most potent immunosuppressive agents. It has almost replaced ciclosporin (CsA) as the drug of first choice for the prevention of graft rejection after kidney transplantation (Bouamar et al, 2013). Tacrolimus was initially available as a preparation requiring twice daily administration: Prograf®. A prolonged release preparation, Advagraf®, has become available recently with proven efficacy and safety following once daily dosing. Tacrolimus has a narrow therapeutic window and its high pharmacokinetic variability renders dose selection challenging. Therefore, therapeutic drug monitoring (TDM) is used routinely to direct tacrolimus dosing. To some extent, this variability is influenced by genetic factors. Enzymes in the cytochrome P4503A family (CYP3A) and the drug transporter P-glycoprotein (P-gp) play important roles in the absorption and metabolism of tacrolimus (MacPhee et al, 2002). The influence of the CYP3A5*3 and ABCB1 3435C>T genotypes on the pharmacokinetics of immediate release tacrolimus; Prograf® is well-defined. However, it is unclear for prolonged release tacrolimus; Advagraf®. Recently identified polymorphisms CYP3A4*22 and P450 Oxidoreductase (POR*28) were reported to have additional effects on tacrolimus pharmacokinetics and dose requirement (Jonge et al., 2011; Elens et al., 2013). Recently, 4β-hydroxycholesterol (4β-OHC) has been shown to be an endogenous marker of P450 3A activity in clinical practice (Diczfalusy et al., 2011). Prednisolone is a known inducer of both CYP3A and P-gp. The role of CYP3A4*22 and POR*28 in prednisolone metabolism is unknown. An inverse correlation between corticosteroid daily dose and tacrolimus exposure was demonstrated in renal transplant recipients (Anglicheau et al., 2003a). Achieving therapeutic trough concentration is of vital importance during the period immediately after transplantation. Therefore, the identification of parameters predictive of the optimal tacrolimus dosage would be a great clinical asset in the determination of adequate tacrolimus administration. Furthermore, high within-patient variability (WPV) in tacrolimus exposure is considered as a risk factor for allograft loss and late acute rejection (Wu, et al. 2011). The causes of this variability are not completely understood.
Teacher as facilitator: A requisite during foundation years of medical curriculum -

The foundation years in medical curriculum, particularly dedicated to basic sciences, mandate a strong inculcation of critical thinking, clinical reasoning, problem solving, decision making, and lifelong learning skills. The steep competition and dramatic upsurge in professional challenges obligate the ability to take responsibility of one’s own learning. The fresh undergraduates, as they step into the competitive and demanding health profession, require adequate grooming in their foundation years so that they are adequately transformed to face the nuances of the same.
Worldwide innovations in the development of carbon capture technologies and the utilization of CO2

While Carbon Capture and Storage (CCS) technologies are being developed with the focus of capturing and storing CO2 in huge quantities, new methods for the chemical exploitation of carbon dioxide (CCU) are being developed in parallel. The intensified chemical or physical utilization of CO2 is targeted at generating value from a limited part of the CO2 stream and developing better and more efficient chemical processes with reduced CO2 footprint. Here, we compare the status of the three main lines of CCS technologies with respect to efficiency, energy consumption, and technical feasibility as well as the implications of CCS on the efficiency and structure of the energy supply chain.
Relationship between two indices in the assessment of orthodontic treatment complexity and need.

Objective: To determine the relationship between the Index of Complexity, Outcome and Need (ICON) and Dental Aesthetic Index (DAI) in the assessment of orthodontic treatment complexity and need. Method s : A cross - sectional study was carried out. Pre - treatment dental casts of 150 consecutive patients from Lagos, Nigeria were assessed using the ICON and the DAI criteria. One investigator assessed all the models. In addition to descriptive statistics, the rel ationship between the ICON and DAI was examined by using non - parametric correlations (Spearman Rank Order and Pearson’s Product Moment Correlation Coefficient. Original Research Article
Prediction of error probabilities for integrated digital synchronizers

Synchronization errors occur when asynchronous digital signals are received by clocked digital systems. Digital synchronizers are designed to minimize the probability of such errors. Empirical determination of error probabilities, as used in the past, is not a viable method for large-scale integrated circuit because it is cumbersome, interferes with the circuit performance, and does not account for tolerances of circuit parameters. The authors describe a complete method for predicting synchronization-error probabilities using circuit simulation and theoretical analysis. The analysis includes the efforts of random noise. The simulation model readily takes into account tolerances of the circuit parameters. The direct observability of all parameters of the model enhances the understanding of the synchronization process and the reliability of the predictions.
Facteurs de variation de la détection des chaleurs chez la vache laitière conduite en vêlages groupés

En systeme laitier a velages groupes, la maitrise de la reproduction - sur une periode a dates fixes - est essentielle a la perennite du systeme. La detection des chaleurs est un prealable indispensable a la mise a la reproduction. Afin de mieux connaitre les facteurs de variation de la detection des chaleurs, nous avons travaille sur une base de donnees constituee de 415 chaleurs detectees de 2001 a 2005 sur le troupeau experimental INRA du Pin au Haras, lors des campagnes de reproduction. Les vaches, de races Prim'Holstein et Normande, etaient soumises a des niveaux d'apports nutritionnels differents permettant de distinguer entre lots les effets de la production laitiere realisee des effets de l'amaigrissement. Dans nos conditions optimales (velages groupes, aire paillee ou pâture), 65 % des chaleurs ont ete detectees sur signes specifiques des chaleurs (acceptation du chevauchement ou chevauchement par l'avant: AC), 21 % sur chevauchement sans AC et 14 % sur les autres signes, dits discrets. Pour les 2 races, les taux de gestation se sont averes meilleurs pour les inseminations sur AC. La presence d'une congenere en chaleurs et la pâture ont favorise les detections sur AC et limite les detections sur signes discrets. En race Normande, sous ces deux conditions, la quasi totalite des detections a repose sur l'AC. En multipares Prim'Holstein, une production laitiere elevee a accru le risque de detection sur signes discrets contrairement a l'amaigrissement post-partum. La production laitiere realisee influerait donc essentiellement de maniere directe sur l'expression des chaleurs et pas forcement au travers de l'amaigrissement post-partum. En conclusion, une conduite alimentaire permettant une production laitiere elevee semble rendre plus difficile la detection des chaleurs, pouvant compromettre la reussite du groupement des velages. Le choix de la race peut egalement se poser dans ces systemes emergents en France.
Kushk-E Hezar: A Mushki/Jari Period Site in the Kur River Basin, Fars, Iran

In May 2003, during an archaeological reconnaissance of the south-western edge of the Kur River Basin, the Fars Archaeology Project team visited the small Mushki/Jari-period site of Kushk-e Hezar (Fig. 1 ). The site, location 6064--8479 in the Kur River Basin Site Gazetteer (Sumner, n.d.), had recently had a metre or so of material scraped off its top by a bulldozer and we felt it necessary to survey the damage, in order to prepare a request to the regional office of the Iranian Cultural Heritage Organization (ICHO), to prevent further destructive activity at the site. As the ceramics on the surface of the exposed deposits showed an interesting combination of Mushki and Jari characteristics, we decided to map the site and take a series of systematic and purposive surface collections from the surface that had been exposed by the bulldozing.
Subject and citation indexing. Part II: The optimal, cluster‐based retrieval performance of composite representations

Measures of cluster‐based retrieval effectiveness are computed for five composite representations in the cystic fibrosis (CF) Document Collection. The composite representations are constructed from combinations of two subject representations, based on Medical Subject Headings and subheadings, and two citation representations, consisting of the complete list of cited references and a comprehensive list of citations for each document. Experimental retrieval results are presented as a function of the exhaustivity and similarity of the composite representations and reveal consistent patterns from which optimal performance levels can be identified. The optimal performance values provide an assessment of the absolute capacity of each composite representation to associate documents relevant to the same query and discriminate between documents relevant to different queries in single‐link hierarchies. The optimal performance values for all composite representations are completely comparable and are superior to the optimal performance of constituent representations. Optimal performance consistently occurs at low levels of exhaustivity. Exhaustive composite representations that include subject descriptions produce the lowest levels of performance; retrieval results derived from random structures are comparable to the observed results. The effectiveness of the exhaustive representation composed of references and citations is materially superior to the effectiveness of exhaustive composite representations that include subject descriptions. © 1991 John Wiley & Sons, Inc.
Trickle-up phonetics: A vocal role for the infant

Falk claims that human language took a step forward when infants lost their ability to cling and were placed on the ground, increasing their fears, which mothers assuaged prosodically. This claim, which is unsupported by anthropological and psychological evidence, would have done little for the syllabic and segmental structure of language, and ignores infants' own contribution to the process.
ReFIoV: A Novel Reputation Framework for Information-Centric Vehicular Applications

In this paper, a novel reputation framework for information-centric vehicular applications leveraging on machine learning and the artificial immune system (AIS), also known as ReFIoV, is proposed. Specifically, the Bayesian learning and classification allow each node to learn as newly observed data of the behavior of other nodes become available and hence classify these nodes, meanwhile, the k-means clustering algorithm allows us to integrate recommendations from other nodes even if they behave in an unpredictable manner. The AIS is used to enhance misbehavior detection. The proposed ReFIoV can be implemented in a distributed manner as each node decides with whom to interact. It provides incentives for nodes to cache and forward others’ mobile data as well as achieves robustness against false accusations and praise. The performance evaluation shows that ReFIoV outperforms state-of-the-art reputation systems for the metrics considered. That is, it presents a very low number of misbehaving nodes incorrectly classified in comparison with another reputation scheme. The proposed AIS mechanism presents a low overhead. The incorporation of recommendations enabled the framework to reduce even further detection time.
An ectopic intramedullary hematopoietic niche in a cervical spine meniscoid: a case report

We present the first documented case of an ectopic intramedullary hematopoietic niche within a cervical zygapophyseal joint intra-articular meniscoid. The meniscoid was identified in the cervical spine of an 81-year-old male cadaver, located at the dorsal aspect of the right C4-5 zygapophyseal joint, and was noted to be larger and more dense than other meniscoids during disarticulation and dissection of the joint. Histologically, the meniscoid contained hematopoietic cells surrounded by lamellar bone, and was lined with articular cartilage on the surface protruding into the joint cavity. Radiologically, the structure was hypointense on both T1- and T2-weighted magnetic resonance imaging sequences. The potential mechanisms underpinning development of this novel finding and the possible clinical implications are discussed in this report.
Geometry and probability on the noncommutative 2-torus in a magnetic field

In this work, we describe the geometric and probabilistic properties of a noncommutative 2- torus in a magnetic field. We study the volume invariance, integrated scalar curvature and volume form by using the method of perturbation by inner derivation of the magnetic Laplacian in the noncommutative 2-torus. Then, we analyze the magnetic stochastic process describing the motion of a particle subject to a uniform magnetic field on the noncommutative 2-torus, derive and discuss the related main properties.
Diagnostic significance of myocardial stress markers in unnatural deaths

urrently, in the aging society that our country is facing, there has been an increasing tendency to see unnatural deaths in the elderly with scant medical histories, measures, and prevention becoming social issues. In forensic medicine, it is extremely important to find the cause of death which should be revealed by autopsy. However, the bodies in many unnatural deaths do not undergo autopsies in Japan but are diagnosed by inspections. To not only elucidate the truth behind an individual's death, but also so as not to miss criminal deaths, it is ideal to reveal the cause of death by autopsies for all deaths, including the elderly; however, in Japan, where the percentage of consented autopsies is remarkably low (0.9%), compared to that in Western countries, the ideal situation is unrealistic. Yet, the diagnostic accuracy of inspections is still low and often misdiagnoses are made; therefore, it is necessary to Original Contribution Kitasato Med J 2010;40:35-41
Facial Emotion Recognition using Concept Mapping and Feature Extraction

In recent years there has been a rapid growth in study of emotions. Humans use facial expression as a nonverbal communication channel. Human Computer Interaction(HCI) is a developing and interesting field and is useful for further development in recent technology. We have developed a computer vision system that recognizes human expressions based on various action units of upper and lower face parts. Firstly, the face is detected from the input video clip then preprocessing, feature extraction is done and the classification of expression is obtained. Six primary expressions happiness, sadness, fear, disgust, surprise and anger are classified using Facial Action Units. Our process considers Facial Action Coding System(FACs) for classification. Concept Map is used to improve the expression classification accuracy, speed of execution and to reduce the confusion between emotions.
Construction of Formal Ontology on Computer

From a general point of view, the defined reality models by using a formal language are called formal ontology. These general purposeful models can be also used in the special fields of application. Because ontologies are large-scale by their nature, they have the potential of hosting errors and deficiencies in case they are generated by human labor. Besides, an ontology formed such a way will be difficult to be adapted to a application specific. In this study, an application of a computerized formal ontology formation saved from probable problems which are likely to arise using human labor will be introduced. In the application, semantic analysis of Turkish has been targetted as a special application field using corpus-based marking method in the framework of formal concept analysis. Beside the applications of these kinds of natural language processing formal ontologies are used considerably in the field of education as they present the information in the way of semantic structures clearly and meaningfully. The most important reasons of this are the use of the information technologies such as expansion of constructivist approach and the concept maps used for educational reasons.
Work, New Technology, and Capitalism

The spread of computers and electronic means of communication has clearly transformed contemporary workplaces. Computers now sit on the desks of virtually all office-based workers, linking them to one another through local area networks (LAN's), electronic mail, and complex information systems. Employees whose jobs involve significant amounts of travel are increasingly armed with an electronic arsenal of laptops, handheld computers, pagers, and cellular phones. Programmable machinery, computer-aided design, computer-based inventory systems, and other innovations have reshaped industrial processes. And, arguably, the separation of work and residence that has characterized industrialized societies is being undermined by the emergence of electronically mediated home work.This article can also be found at the Monthly Review website, where most recent articles are published in full.Click here to purchase a PDF version of this article at the Monthly Review website.
Alternative Option Selection Methods in Menu-Driven Computer Programs

In menu-driven computer programs the user is often required to select an option from among several alternatives. The most common response system for this selection is the standard keyboard. Three response selection methods were evaluated: using a key-controlled cursor to point to the desired option, keying a digit to indicate the desired option, and keying a letter that served as a mnemonic device. The speed and errors of selecting options with the alternative methods were studied as a function of (1) the number of the alternative options in the array and (2) familiarity with the program and the options. Results demonstrated the superiority of the meaningful letter code, and the differential and lower effectiveness of cursor and digit as a function of level of practice and number of options. A default selection method that utilizes the practice effect is recommended.
Aerologische Untersuchungen der tagesperiodischen Gebirgswinde unter besonderer Berücksichtigung des Windfeldes im Talquerschnitt

Observations dans la vallee de Loisach dans la region de Garmisch-Partenkirchen. Description detaillee du systeme des vents. Comparaison avec les vents dans la vallee de l'Inn (experiences d'Innsbruck 1978). On note une remarquable similitude de l'evolution de la circulation dans les deux vallees malgre les differences de dimensions de ces dernieres. Particularite durant la periode de transition du jour vers la nuit: L'ecoulement est fortement asymetrique par rapport a l'axe de la vallee. Discussion du probleme des vents de compension (appeles aussi anti-vents) dans les couches plus elevees