Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlates of unprotected sex by client type among female sex workers that inject drugs in Tijuana and Ciudad Juarez, Mexico.

Aims Risk environment factors may influence unprotected sex between female sex workers who are also injection drug users (FSW-IDUs) and their regular and non-regular clients differently. Our objective is to identify correlates of unprotected vaginal sex in the context of client type. Methods A cross-sectional survey of 583 FSW-IDUs in Tijuana and Ciudad Juarez, Mexico, was analyzed using negative binomial regression to determine physical, social, economic, and policy risk-environment factors that affect the frequency of unprotected sex with regular and non-regular clients. Results Median number of unprotected vaginal sex acts in the past month among FSW-IDUs and their regular and non-regular clients was 11 (IQR 3-30) and 13 (IQR 5-30), respectively. Correlates differed by site and client type and were most closely associated with the risk environment. In Tijuana, social factors (e.g., injecting drugs with clients) were independently associated with more unprotected sex. Factors independently associated with less unprotected sex across client type and site included social and economic risk environment factors (e.g., receiving more money for unprotected sex). In the policy risk environment, always having free access to condoms was independently associated with less unprotected sex among non-regular clients in Tijuana (Risk rate ratio = 0.64; 95% confidence interval 0.43-0.97). Conclusions Primarily physical, social, and economic risk-environment factors were associated with unprotected vaginal sex between FSW-IDUs and both client types, suggesting potential avenues for intervention.
An analysis of dental treatments rendered by undergradutes at ajman university to patients from fujairah, UAE

Objectives: This study undertaken to highlight the dental treatments delivered by undergraduate students at Ajman University to patients from Fujairah and to examine the relationship between ages, gender, and the types of dental treatments. Materials and Methods: A total of 650 dental records were selected from 6000 dental records of patients who had received dental treatment in the Dental Clinic, College of Dentistry, Ajman University(AU)-Fujairah Campus, between academicyear,2015/2016 and 2016/2017. Results: The combination of restorative treatments(composite, amalgam and glass ionomer) adds up to 34.4%, of the total services received by patients, followed by 21.6% scaling &polishing, 15.5% extraction and 13.47% endodontic procedures. The combination of preventive treatments 4.2%, pediatric treatments, add up to 5.5% and prosthetic treatments contributed for 5.4%. Using the SPSS, Regression option. It was found that no significant regression between the gender and the treatments (sign = 0.699), but there was a significant regression between the age and the treatments (sign = 0.00). Chi-square test shows a significant association (sign=0.0) between age groups and removable prosthetic dominant at age group (32-44 years). There is, a significant association between age groups, and the following dental treatments: fluoride, fissure sealants, spacemaintainer, pulp-therapy, stainless steel crown and glass-ionomers dominant at age group (6-18years). No association between gender & types of dental treatments. Conclusion: The study demonstrates the types and amount of dental treatments given to patients from Fujairah by under graduate dental student as part of their clinical training program through, Dental School’s clinic, Ajman UniversityFujairah campus. Further large-scale study to assess the quality and patients’ satisfaction regarding the treatments provided by under graduate students is highly recommended.
Riesgo Biológico Ocupacional en la Medicina Veterinaria, Área de Intervención Prioritaria

Occupational biological hazard in Veterinary Medicine: an area for priority interventions Veterinary medicine is an activity related to several health hazards; during the last years, studies about the biological hazard associated to animals have been conducted, such hazards represented by the zoonotic diseases and the allergic reactions in exposed workers. Despite its importance, in Colombia the knowledge about the occupational biohazard is scarce, its magnitude is overlooked and in addition a passive attitude from practitioners exists. The few research spaces available and
Alternative Approach to Removal of a Retained Chest Tube

Chest tubes are a staple of cardiothoracic surgery used both in the pre-operative setting and post-operatively. Placement of the chest tube is equally as important as removal. When a chest tube cannot be removed, most often due to a suture through the tube, it typically results in the patient returning to the operating room for an additional procedure. Alternatively, by using fiberoptic bronchoscopy, the physician can visualize the problem and use endoscopic instruments to correct it, thereby saving the patient from having to endure another invasive procedure.
Early versus Delayed Laparoscopic Cholecystectomy for Management of Acute Calculus Cholecystitis: Our Experience at King Hussein Medical Center

Objective: To compare early laparoscopic cholecystectomy during index admission with delayed (interval) laparoscopic cholecystectomy in the management of acute cholecystitis at King Hussein Medical Center. Methods: Over the study period of 48 months (June 2005 to May 2009), a total of 317 patients with clinical and radiographic diagnosis of acute cholecystitis were studied. One hundred-thirty one patients underwent laparoscopic cholecystectomy during the index admission (group A) while 186 patients (Group B) underwent cholecystectomy at least six weeks after the attack. Data analyzed included patients’ age, gender, duration of symptoms, white blood cell count, operative time, hospital stay, overall surgical outcomes and postoperative morbidity and mortality. Results: Both groups were demographically and clinically comparable. Surgical outcomes were comparable in group A and B with conversion rates of 8.3% and 7.4% (p = 0.6645), and complication rates of 12.25% and 12.6% (p = 0.9352) respectively. Although delayed surgery shortens operative time significantly (60 versus 100 min, p<0.0001), the overall hospital stay is significantly reduced by early operation (5 versus 14.6 days, p<0.0001). Conclusion: Although both the early and delayed approaches in management of acute calculus cholecystitis are comparable in terms of complication and conversion rates, the early approach has the advantage of offering patients a definitive treatment while reducing the overall total hospital stay and avoiding the problems of failure of delayed therapy.
MiR-4766-5p Inhibits The Development And Progression Of Gastric Cancer By Targeting NKAP

Purpose It is widely known that some specific microRNAs can regulate the expressions of genes in gastric cancer cells at the post-transcriptional level. Previous studies have identified that miRNA-4766-5p was involved in tumor cell proliferation and can be an independent prognostic indicator for malignant pleural mesothelioma. However, the mechanism underlying gastric cancer via the miRNA-4766-5p pathway remains to be blank. Methods We investigated the expression of miR-4766-5p in gastric cancer tissues and cells through qRT-PCR. We used RNAi to change the expressions of miR-4766-5p in gastric cancer cell lines, AGS and MKN45. Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to detect the mRNA expression of miR-4766-5p. We identified cell proliferation by CCK8 and clone formation assays. We analyzed the cell apoptosis and cycle through flow cytometry. At last, we used a dual-luciferase reporter assay to illustrate the interaction between miR-4766-5p and NKAP and used Western blot to determine the protein expression of signaling pathways. Results We found that 1) miR-4766-5p was down-regulated in gastric cancer tissues and cells lines; 2) miR-4766-5p inhibited cell proliferation of gastric cancer cell lines significantly; 3) miR-4766-5p significantly inhibited cell migration and invasion of gastric cancer cells; 4) miR-4766-5p induced gastric cancer cell apoptosis. 5) NKAP was a direct target gene of miR-4766-5p; and 6) miR-4766-5p induced inactivation of AKT/mTOR pathway. Conclusion The above results indicate that miR-4766-5p suppressed the proliferation and metastasis of gastric cancer cells through targeting NKAP. Our findings could probably contribute to the diagnostics and prognostics of gastric cancer through new methodologies.
FALL INJURY CHARACTERISTICS AMONG HIP FRACTURE CASES LIVING IN THE COMMUNITY: IMPLICATIONS FOR COMMUNITY-BASED FALLS PREVENTIVE PROGRAMS

Objective: To elucidate if falls are commonly associated with hip fractures among community- dwelling adults and to detail the most common modes of fall injuries associated with hip fractures. Method: A retrospective analysis of 990 hip fracture case records reported verbally by patients undergoing hip surgery at one of three community-based urban hospitals over an 8-year period was conducted to establish the proportion of cases who reported falling prior to fracturing their hips; how frequently those reporting falls fell in the home or out of doors in traffic areas; and the primary injury modes in and outside the home. Results: Seven cases reported no falls history, and three could not recall any event prior to their hip fracture. For the remaining 90% of cases, which included adults ages 23-95, overall rates of falling in the home were 60.7%; however, when disaggregated for those younger than 60 years of age, falls that occurred out of doors were more common. Regardless of age, a multiplicity of both indoor and outdoor falls-related situations were reported. Conclusion: The majority of hip fractures that occur in the community are associated with a simple fall, and are hence probably preventable. While falling in the home and fracturing a hip is more common than falling and fracturing a hip out of doors, this trend is reversed for people younger than 60 years of age. Many different modes of falling appear to be associated with hip fracture in both venues, regardless of age.
Preventing running injuries

OBJECTIVE To present a practical approach for preventing running injuries. QUALITY OF EVIDENCE Much of the research on running injuries is in the form of expert opinion and comparison trials. Recent systematic reviews have summarized research in orthotics, stretching before running, and interventions to prevent soft tissue injuries. MAIN MESSAGE The most common factors implicated in running injuries are errors in training methods, inappropriate training surfaces and running shoes, malalignment of the leg, and muscle weakness and inflexibility. Runners can reduce risk of injur y by using established training programs that gradually increase distance or time of running and provide appropriate rest. Orthoses and heel lifts can correct malalignments of the leg. Running shoes appropriate for runners’ foot types should be selected. Lower-extremity strength and flexibility programs should be added to training. Select appropriate surfaces for training and introduce changes gradually. CONCLUSION Prevention addresses factors proven to cause running injuries. Unfortunately, injury is often the first sign of fault in running programs, so patients should be taught to recognize early symptoms of injury. RESUME
Helping patients cope with chronic fatigue syndrome

M yalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, potentially disabling condition characterized by extreme fatigue, persistent flu-like symptoms and other typical symptoms. It affects an estimated 0.4–1% of people and is six times more prevalent in women than men. Public awareness of ME/CFS and healthcare professionals’ knowledge about the condition frequently lag behind research, often leading to inadequate management. Although no drug can cure or significantly decrease the core symptoms of ME/ CFS, drugs are very useful for symptom management. Pharmacists are in an ideal position to educate patients about why certain drugs are being used and assist them in managing common side effects. This article provides an overview of ME/CFS, with a focus on pharmacotherapy based on the 2003 Canadian clinical practice guidelines developed by an international expert consensus panel. Unlike previous diagnostic criteria and treatment recommendations, these guidelines are evidencebased and developed from the best available research. Dr. Eleanor Stein (espc@shaw.ca) is a psychiatrist with a private practice in Calgary dedicated to clients with ME/CFS and related disorders. She is the leader of the ETeam (eteam@shaw.ca), a multidisciplinary group that objectively tests the cognitive and sensory deficits associated with these disorders.
Uso de la acupuntura en el tratamiento de la infertilidad. Revisión sistemática de la literatura

Background Infertility is a common problem in the population. Acupuncture is a treatment for this condition but there is no performance evaluations from evidence-based medicine. Objective To evaluate the efficacy and safety of acupuncture in the treatment of infertility. Methodology We conducted a systematic review searching databases (PubMed, Embase, Ovid and Lilacs) clinical trials and other studies in humans to evaluate the use of acupuncture in the management of infertility. There were two groups one for clinical analysis and one for other methodological designs. In clinical trials conducted a qualitative and quantitative analysis (meta-analysis). With other designs qualitative analysis was performed. Results We included 11 trials, four observational studies and two quasi-experimental studies. In female infertility acupuncture showed no significantly different results. In male infertility could improve aspects of semen. Conclusion With the current evidence is concluded that acupuncture is an effective tool for management of infertility in women. In man presents a favorable effect. More studies are.
ROLE OF CLINICAL PHARMACIST IN EDUCATING OBESE AND OVER WEIGHT PATIENTS FOR BETTER HEALTH RELATED OUTCOMES

Obesity is a chronic disease in which there is excessive fat accumulation that presents a risk to public health. Health care interventions can increase awareness about obesity and its complications and it is of great concern to motivate them to change their lifestyle in order to avoid health issues. The aim of this study was to carry out educational intervention for the obese and overweight patients to improve disease outcomes. A prospective hospital based interventional study was carried out for a period of 6 months at St. Philomena’s hospital in Bangalore. Patients visiting medicine department with a body mass index (BMI) ≥ 25 kg/m 2 , patients with known eating disorders and those referred to the young adult section of the obesity clinic were included in the study. A questionnaire was prepared and was introduced to the study subjects after validation. Patient information leaflets (PIL) were given to the patients to educate them about the obesity. Scores were recorded pre and post counseling to analyze for the effectiveness of counseling. A total number of 95 obese patients were enrolled in the study who belonged to young adults and adult’s age group. Majority of patients were in age between 46-50 years. Male proportions were more than females and most of the subjects were overweight. The difference between post and pre counseling score in questions concerning their lifestyle, which includes trying out strategies to lose weight, the habit of eating fruits, performing exercises and their knowledge and effort to prevent obesity in their families were found to be statistically significant. Counseling provided with the aid of patient information leaflet was beneficial in a significant change in habits and behavior of obese subjects. KEYWORD: Obesity, body mass index, pharmacist, education, counseling Received on: 29-05-2019 Revised and Accepted on: 09.08. 2019 DOI: http://dx.doi. org/10.22376/ijpbs/lpr.2019. 9.4. P1-6 Dr. DORNA KARAMI * Pharm D (Intern), Department of Pharmacy Practice, Al-Ameen College of Pharmacy Practice, Bengaluru, Karnataka, India. Int. J. Life Sci. Pharma Res. 2019 Oct; 9(4): (P) 1-6 ISSN 2250-0480 This article can be downloaded from www.ijlpr. com
Machine learning based prediction of antibiotic sensitivity in patients with critical illness

Rising antibiotic resistance inflicts a heavy burden on healthcare, both clinically and economically. Owing to the time required to obtain culture and sensitivity test results, quite often the clinicians rely on their experience and static clinical guidelines to prescribe antibiotics. Such empirical treatment often fails to account for patient-specific attributes and changes in the antibiotic resistance patterns with time and location. The aim of this study was to analyze the patient and hospital specific features regarding their prognostic relevance to treat bacterial infections of patients in the intensive care units (ICUs). We performed a single-center retrospective cohort analysis across 25526 positive cultures recorded in MIMIC-III critical care database. We retrieved a number of clinically relevant relationships from association analysis between patient factors and bacterial strains. For instance, higher elapsed time from patient admission to sample collection for culture showed strong association with blood stream infection caused by Enterococcus faecium, Pseudomonas aeruginosa, and Staphylococcus, indicating that these infections are possibly hospital acquired. To predict antibiotic sensitivity at the level of individual patients we developed an ensemble of machine learning algorithms. The model provided superior prediction accuracy (about 87%) and area under the ROC curve (around 0.91 on an average) for the four most common sample types as compared to a number of off-the-shelf techniques. We demonstrate the predictive power of commonly recorded patient attributes in personalised prediction of antibiotic efficacy.
Managing healthy women at risk of breast cancer

SYNOPSIS Early detection with effective treatment has reduced mortality in some groups of women with breast cancer, however reducing the risk of breast cancer is clearly an important goal. Several risk factors for breast cancer have been identified. The most important of these are ageing and a positive family history. Models incorporating these risk parameters are available to help identify women who may benefit from the various risk reduction approaches. Optimal breast cancer prevention strategies in high-risk women are still to be determined and are the subject of ongoing clinical trials.
Prevalence and Clinical Significance of Low Avidity HPA-1a Antibodies in Women Exposed to HPA-1a During Pregnancy

Abstract 266 Neonatal alloimmune thrombocytopenia (NAIT) is caused by maternal antibodies specific for fetal platelet antigens and is the most common cause of intracranial hemorrhage in full term infants. The antigen HPA-1a, carried on beta 3 integrin (GPIIIa), is the most common trigger for NAIT and the 2% of women who are HPA-1a-negative are at risk to produce such antibodies. Most HPA-1a antibodies causing NAIT can be easily detected but it is not rare for an HPA-1a negative mother who lacks detectable antibodies to give birth to an infant with thrombocytopenia. Several recent reports suggest that low avidity HPA-1a antibodies not detected by conventional serologic methods are responsible for some of these cases (Socher 2009, Bakchoul 2011). To examine this question, we retroactively analyzed a cohort of 3478 suspected NAIT cases referred for laboratory diagnosis. Among 677 HPA-1a-negative mothers, we identified 61 in whom HPA-1a-specific antibodies were not detected by conventional methods. Surface plasmon resonance (SPR) analysis enables ligand-receptor interaction to be studied in real time without washing the target. Using this approach, we studied reactions of IgG from the 61 archived serum samples against purified GPIIb/IIIa isolated from group O platelets and identified 18 samples that reacted preferentially with the HPA-1a-positive version of the integrin in comparison with HPA-1a-negative integrin. Information defining clinical status was obtained on 13 of these cases by follow-up communication. Seven cases had been referred because of neonatal thrombocytopenia. Platelet nadirs ranged from 8,000/ul to 141,000/ul (median 38,000/ul). Five of the 7 infants had bleeding and were given maternal platelet transfusions and/or IVIgG. Normal platelet counts were achieved after 4 to 70 days (median 7 days). One infant had a normal platelet count, however IVIgG had been given to its mother throughout pregnancy. The remaining 5 cases were referred in mid-pregnancy because an HPA-1a-negative sister previously gave birth to an infant with NAIT. Four of these infants had normal platelets at birth; one had mild TP (platelets 125,000/ul). Only 3 of 12 mothers typed for HLA were positive for HLA-DRB3*0101, a marker found in >95% of women who make “conventional” HPA-1a antibodies during pregnancy (p These findings indicate that low-avidity HPA-1a antibodies not detectable by conventional serologic methods are made by a subset of women exposed to the HPA-1a antigen during pregnancy and that some, but not all of these antibodies are capable of causing NAIT, which is usually mild, but can be severe. Women negative for HLA-DRB3*0101 may be especially prone to produce antibodies of this type. Maternal-fetal incompatibility for platelet antigens other than HPA-1a is very common and many apparent NAIT cases not involving HPA-1a go unresolved. The possibility that low avidity antibodies specific for antigens other than HPA-1a are responsible for some of these cases deserves study. Disclosures: No relevant conflicts of interest to declare.
THE ROLE OF DRAWING’S ANATOMY IN PROMOTING NURSING STUDENTS ANATOMY EDUCATION IN PARA- MEDICAL NURSING –MIDWIFERY FACULTY IN GUMS

مقدمه: درس آناتومی برای اغلب دانشجویان به منزله یک درس غیرقابل درک، که به ذهن سپاری آن مشکل و فراموشی آن سریع اتفاق می افتد، تلقی می شود، لذا این مطالعه با هدف تعیین نقش آناتومی ترسیمی در ارتقاء کیفیت آموزش آناتومی در دانشجویان انجام شد. روش ها: مطالعه بصورت نیمه تجربی بر روی380 نفر از دانشجویان پرستاری، مامایی و پیراپزشکی لنگرود در سال های90-89 طی چهار نیمسال انجام شد. نمونه ها به روش تصادفی در هر کلاس به دو نیمه تقسیم شدند. جهت نیمی از دانشجویان هر کلاس صرفا از تدریس همزمان تئوری و عملی آناتومی، به کمک وسایل سمعی و بصری، جسد و مولاژ و جهت نیمی دیگر از دانشجویان همان کلاس (یعنی گروه تجربی) علاوه بر روش های مذکور، از ترسیم نیز استفاده شد. دیدگاه دانشجویان گروه تجربی نیز نسبت به این شیوه تدریس با استفاده از پرسشنامه ای که روایی صوری و محتوایی آن با نظر سنجی از همکاران محترم عضو هیئت علمی دانشکده تایید شده بود، بررسی شد و نتایج حاصل با استفاده از آزمون های آمار توصیفی و استباطی (t مستقل) و از طریق نرم افزار SPSS مورد تجزیه و تحلیل قرار گرفت. یافته ها: نتایج نشان داد که فراگیران گروه تجربی میانگین نمره بالاتری نسبت به گروه دیگر کسب نمودند ](1/35± 16) نسبت به (0/23± 13)[ که تفاوت معنادار بود (، t=2/14 and p=0/137). درگروه تجربی 88/7 درصد ازدانشجویان، این روش تدریس را به میزان بسیار زیاد نسبت به روش های مرسوم ترجیح دادند. 63 درصد این روش را بسیار زیاد جذاب و 57 درصد نیز اعتقاد داشتند که این شیوه سبب افزایش مهارت آن ها در بخش بالین خواهد شد. نتیجه گیری: نتایج نشان داد ترسیم در امر یادگیری درس آناتومی دانشجویان به طور معنی دار موثر بوده است و اکثریت دانشحویان از این شیوه تدریس رضایت زیادی داشتند.