Miracle-dz/UniFAR-FTUs huggingface dataset:
Limitations des données sur l’activité physique du Canada : répercussions sur les tendances de la surveillance

The current low level of physical activity among Canadians is a dominant public health concern. Accordingly, a clear understanding of physical activity patterns and trends is of paramount importance. Irregularities in monitoring, analysis, and reporting procedures create potential confusion among researchers, policy-makers, and the public alike. The purpose of this paper is to consolidate reported findings and provide a critical assessment of the physical activity surveillance procedures, analytical practices, and reporting protocols currently employed in Canada to provide insights for accurate and consistent interpretation of data, as well as recommendations for future surveillance efforts.
Histopathology of the Gastroesophageal Junction

The entire gastroesophageal junction of 36 patients who had been operated for squamous cell carcinoma of the upper or middle esophagus was examined. Hematoxylin and eosinstained slides were evaluated by two pathologists for the following histologic details: minimal and maximal length of cardiac mucosa (CM) and oxyntocardiac mucosa (OCM, mixture of cardiac and fundic glands), degree of inflammation in CM and OCM, and presence of intestinal metaplasia or pancreatic metaplasia. Sections of gastric corpus mucosa were evaluated for the presence of gastritis and Helicobacter pylori infection; sections of esophageal squamous epithelium were evaluated for the presence of reflux esophagitis. CM was present in the entire circumference of the gastroesophageal junction in 20 cases, in parts of the circumference in 15 cases, and entirely absent in one case. The maximal length per case ranged between 1 and 15 mm (median 5 mm). OCM was circumferentially present in 22 cases and partially present in 14 cases. The maximal length ranged between 2 and 24 mm (median 7 mm). Locations of CM/OCM over submucosal esophageal glands or squamous epithelium-lined ducts, both indicating a location in the esophagus, were found in eight cases (22%) and in four cases (11%), respectively. In 18 cases (50%) intestinal metaplasia was present in CM/OCM; pancreatic metaplasia was found in 22 cases (61%). A statistically not significant trend for increase of minimal length of CM, OCM, and the sum of both was found in the presence of gastroesophageal reflux disease. Neither the presence of intestinal metaplasia nor of pancreatic metaplasia in CM/OCM was correlated with gastroesophageal reflux disease. In conclusion, the high variability in length, the frequent occurrence of intestinal metaplasia and pancreatic metaplasia, and the frequent extension into the esophagus suggest that CM/OCM is a dynamic structure that probably mirrors the influence of underlying gastroesophageal diseases. Because of the short length and incomplete circumferential extension of CM/OCM, future endoscopic–bioptic investigations will probably have to be based on more extensive sampling of the gastroesophageal junction.
Do testosterone supplements enhance response to phosphodiesterase 5 inhibitors in men with erectile dysfunction and hypogonadism: a systematic review and meta-analysis

Background Combining testosterone and phosphodiesterase 5 inhibitors (PDE5-Is) has become increasingly common in the treatment of men with erectile dysfunction (ED) and low testosterone levels, but combination therapy involving PDE5-Is and testosterone is highly debated, with strong reasons for and against argued by the various opinion leaders. PDE5-Is can be given prior to, alongside or after the commencement of any testosterone replacement therapy. Meanwhile, combination of PDE5-Is and testosterone is reported to better increase testosterone levels and thus improve International Index of Erectile Function (IIEF) score in hypogonadal men. The objective of this meta-analysis was to assess whether testosterone therapy (TTh) can possibly enhance the reaction to PDE5-Is in men with ED and hypogonadism. Methods Relevant studies and available data were extensively collected form Medline, Embase, and Cochrane Library databases until June 2019. We calculated standard mean differences (SMDs) with their 95% confidence intervals (CIs) for IIEF including IIEF-5 and IIEF-EFD. Trial sequential analysis (TSA) was performed to explore whether the sample size of the accumulated evidence is sufficient. Results There were 8 studies including 913 patients. The pooled SMD of erectile function (EF) component change was 0.663 [(0.299 to 1.027); P<0.0001], which concluded that combination therapy (TTh plus PDE5-Is) is superior to PDE5-Is monotherapy group. We also conducted a subgroup analysis according to trial follow-up, baseline serum total testosterone, baseline EF score and PDE5-Is type, which may explain for the underlying source of heterogeneity in part. The frequency of adverse events and change in PSA levels did not differ between the 2 groups. None of the patients experienced an increase in the prostate specific antigen (PSA) level above 4 ng/mL. Hematocrit increased significantly more in the testosterone group than in the placebo group but not greater than 0.54. Conclusions In summary, the present results confirm that combination therapy is effective and safe. TTh can enhance the reaction to PDE5-Is in men with ED and hypogonadism, but this effect also depends on the specific diagnosis and initial response to PDE5-Is. Most patients with adverse events during treatment are mild, and have a stable overall safety of combination therapy.
Staff regard towards working with patients with co-morbid depression andsubstance misuse: an exploratory study

Background. Patients having co-morbid mental health and substance misuse experience poorer treatment outcomes than those treated for either condition alone. Studies suggest health professionals regard towards these patients is a factor. Aims. To compare regard towards patients with co-morbid depression and substance misuse across different health professions and services, relative to independent conditions (depression, diabetes, alcohol and/or drug misuse). Methods. A cross-sectional comparative exploratory study of regard towards five patient groups conducted on multi-disciplinary staff (general practitioners, psychiatrists, psychologists, nurses and social workers. Total n=113) in three Scottish NHS board regions – NHS Fife, Tayside and Forth Valley. Services from three main treatment entry points were recruited in each region - 10 primary care services (43.5%), 7 mental health (70%) and 4 specialist addiction (100%). Descriptive statistics were calculated for regard towards each patient group. Multifactorial between subjects ANOVA examined influences on Medical Condition Regard Scale (MCRS) scores. Results. Regard towards patients with co-morbid depression and substance misuse was frequently lower than towards patients with independent conditions. Male professionals held lower regard towards these patients than female (p=0.03). Addiction services held the highest regard and general practice lowest (p <0.001). Over-45’s held the lowest regard towards these patients (p=0.02). Health professional’s satisfaction with working with these patients was also low (mean 1.98, sd 1.22) compared to other conditions. Conclusions. Regard towards patients with co-morbid depression and substance misuse is lower than either condition independently, particularly among older, male professionals and those in general practice.
Learn a Global Appearance Semi-Supervisedly for Synthesizing Person Images

We present a novel approach for person images synthesis in this paper, that can generate person images in arbitrary poses, shapes and views. Unlike existing methods just using keypoints’ locations in heatmaps format, we propose to render SMPL model to UV maps, which can provide human structural information about poses and shapes. Thus, by varying the parameters of poses, shapes and camera in SMPL model, we can generate different person images with various attributions in a simple way, while in most cases we can only obtain new shapes of people by computer graphics methods. We train an end to end generative adversarial network with unlabeled data. As our SMPL parameters come from a pretrained model, we call our overall network semi- supervised. Our network keeps a global appearance during the fine-tuning stage of the target person, thus we can get a complete appearance of the target person, rather than the inaccurate appearance caused by inferencing without enough information. Experiments on Human3.6M Dataset and a self-collected dataset demonstrate the excellent effectiveness of our approach on person images synthesis for different applications.
SNPTEST v2 Technical Details

1 Testing for association at imputed SNPs 2 1.1 Frequentist tests . 2 1.1.1 Missing data likelihood theory . 2 1.1.2 Score tests . 3 1.1.3 Maximum Likelihood Tests . 4 1.1. 4 Expected count tests . 5 1.1. 5 Thresholded tests . 5 1.2 Bayes Factors . 5 1.3 Bayes Factors versus p-values . 7
LEPTIN AND ADIPONECTIN LEVELS OF ASTHMATIC IRAQI CHILDREN IN HILLA PROVINCE

Objective: To assess the serum leptin and adiponectin in Iraqi children with asthma and compare it with healthy controls in Hilla province.Methods: Leptin and adiponectin were measured in 100 children; 60 newly diagnosed with asthma and 40 non-asthmatic children with a comparable age and sex were enrolled in this study. Asthmatic children subdivided into two groups; 30 patients in each group (obese and non-obese). The age of patients and control ranged between 2 and 12 years. The study was conducted in the Department of Biochemistry, College of Medicine, University of Babylon, leptin and adiponectin were estimated by enzyme-linked immunoassay, enzyme-linked immunosorbent assay technique.Results: An increase in leptin and decrease adiponectin levels in the obese group than in non-obese asthmatic and control groups, with significant difference (p<0.04) and (p<0.03), respectively.Conclusion: Among obese asthmatic Iraqi children, increase and decrease levels of leptin and adiponectin, respectively, indicate the significant association between adipokines and obesity in asthma. Â
Job Satisfactionamong College Teachers

The present study is an attempt to evaluate the job satisfaction of college teachers and to investigate the impact of age, gender, location and category on teacher’s job satisfaction. A few secondary schools were selected from Guwahati to Chhaygaon area of Kamrup district of Assam. A sample of 68 college teachers were selected through random sampling technique. A job satisfaction Scale (JSS) prepared by Dr.Amar Singh and Dr.T. R. Sarma was employed to collect data. The analysis of data using Mean, S.D. and t-test revealed that there is no significant difference between male and female teachers in their job satisfaction. It was also observed that level of job satisfaction increases with the increase of age.
of (Beta-2 Microglobulin Type) in the

ow naded rom http:urnals.lw w om am jerm atothology by hD M fePH bH 4TIm qVAH xkFJpPk1L/H vM G w qM xG jw O deJPG +b4D lKuA44qu/vw zm c= on 079/2018 Downloadedfromhttp://journals.lww. com/amjdermatopathologybyBhDMf5ePHKbH4TTImqenVAHxkFJp/XpPk1L/H3vMGwqMxG9jwOd8eJPG+b4DlKuAX44qu/vwzmc=on07/29/2018 biopsy of the axillary mass, reviewed at the referring institution, revealed lymph node reactive hyperplasia without evidence of malignancy. Fine needle aspiration and flow cytometry of the submental mass and adjacent lymph node, reviewed at our institution, demonstrated a clonal diffuse infiltrate of small B cells, negative for CD23, CD5, cyclin D1, and CD10, and thus consistent with a low-grade B-cell lymphoma. Several months later, she noticed “golf ball– sized” enlargement of the right axillary mass. Excisional biopsy, reviewed at our institution, revealed a malignant epithelioid process in one lymph node (Fig. 1A). Because of lack of an obvious primary malignancy, we used a panel of immunohistochemical studies. Immunohistochemistry demonstrated tumor cell positivity with a melanocytic cocktail and anti-PLAP antibody with a cytoplasmic pattern while being negative for keratin (Figs. 1B, C). Based on the labeling with the melanocytic cocktail and the history of subungual melanoma, we established a diagnosis of metastatic melanoma. The patient underwent completion lymphadenectomy with a total of 2 of 15 axillary lymph nodes positive for melanoma, with a largest tumor deposit of 63 mm. During a follow-up of 10 months, the patient has developed multiple metastases to the lungs, liver, and spleen. She was started with high-dose interferon with minimal response. She recently started with a protocol of ipilimumab and temozolomide. It has been previously proposed that cytoplasmic reactivity of PLAP may represent nonspecific binding of the antibody, particularly because of its reported subcellular localization in the cytoplasmic membrane. However, because both cytoplasmic and membranous labeling is observed in placenta and seminoma, the cytoplasmic expression is more likely to be a result of abnormal subcellular localization of the protein. The only previous mention of alkaline phosphatase in metastatic melanoma was in a histochemical study by Kabat and Furth. They investigated the presence of alkaline phosphatase in both normal and malignant tissues, of which 2 samples were malignant melanoma. Both of these samples failed to demonstrate alkaline phosphatase histochemical reaction. In conclusion, to our knowledge, we report the first case of PLAP positivity in metastatic melanoma. Histopathologists should be aware of this possibility, as PLAP may be used in immunohistochemical panels in diagnostic surgical pathology and dermatopathology and thus may be a possible source of misdiagnosis.
Senile EBV+ B-Cell Lymphoproliferative Disorders

Twenty-two Epstein-Barr virus-associated B-cell lymphoproliferative disorders (LPDs) without predisposing immunodeficiencies were evaluated clinically and pathologically. All patients were Japanese and negative for anti-human immunodeficiency virus antibody. They were all more than 60 years old with a median age of 75.5 years. Eighteen (82%) patients showed extranodal involvement. Biopsied specimens contained variable numbers of centroblasts, immunoblasts, and ReedSternberg-like giant cells often with necrosis and an angiocentric pattern. The 13 cases showing polymorphous composition and inflammatory background were categorized as polymorphic LPD subtype. The other nine cases contained diffuse proliferative lesions of large lymphoid cells and were categorized as large cell lymphoma subtype. Tumor cells expressed CD20 and/or CD79a, and in situ hybridization showed them to be associated with Epstein-Barr virus. LMP1 was detected in all cases and EBNA2 in seven. Eighteen patients initially received combination chemotherapy, and 12 achieved complete remission. However, six patients were refractory to chemotherapy and four patients with complete remission later relapsed. Eight of the 18 patients who received chemotherapy showed an aggressive disease course within a year after the diagnosis. There was a significant difference in prognosis between the group with polymorphic LPDs and the one with large cell lymphomas (p 0.003). Although the disease profile of the 22 cases was analogous to that of immunodeficiency-associated B-cell LPDs, none of the patients showed evidence of underlying immunodeficiency-related diseases. These findings suggest that Epstein-Barr virus-associated LPD without immunodeficiency mainly occurs in elderly patients. Further investigations are needed to clarify the pathogenesis of this disease and to determine the optimal treatment strategy.
BIOLOGICAL EFFICACY OF CENTELLA ASIATICA (L) urban AGAINST OPPORTUNISTIC PATHOGENS

An assay was carried out to study the antimicrobial activity of ethyl acetate, ethanol, acetone, chloroform and petroleum ether extracts of Centella asiatica (L) urban herb by disc diffusion assay. The tested bacterial strains were Staphylococcus haemolyticus, Staphylococcus lentus, Staphylococcus aureus, Bacillus cereus, Eschericia coli, Serratia marcescens, Enterobacter amnigenous, Klebsiella pneumoniae, Klebsiella oxytoca and Brevibacterium paucivorans. Zone of inhibition produced by different extracts against the selected strains was measured and compared with standard antibiotic chloramphenicol (30μg). The present study demonstrated that the ethyl acetate, ethanol and acetone extract of Centella asiatica have higher antimicrobial activities (average 7-12 mm zone of inhibition) than n-hexpetroleum ether and chloroform extracts. All the extracts showed better results against the tested bacterial strains comparing with chloramphenicol (30μg). The results obtained in the present study suggest that the different extracts of Centella asiatica revealed a significant scope to develop a novel broad spectrum of antibacterial effect.
Subperiosteal chin augmentation with hyaluronic acid filler in patients with a small chin

Background: For correction of small chin, surgical genioplasty, allograft implantation, and injectable filler have been widely used. Among these, the injectable fillers is a simple, non-invasive procedure that has minimal downtime and low risk of complications. It has been commonly injected at intradermal, subdermal, submuscular and supraperiosteal layer. However, common complications such as nodules, bumps, lumps, migration, asymmetry, overcorrection, and chin ptosis frequently happened. Objective: The main objective of this study was injecting filler into sub-periosteal layer in a small chin and evaluated its effect and incidence of complications. Methods: A total of 14 subjects aged between 33 and 64 years had been performed Elravie ® hyaluronic acid filler injection subperiosteally and Medytoxin ® as a botulinum toxin treatment intramuscularly. Morphological change were observed through the photos. Changes of proportion of lower 1/3 face, Modified Legan’s angle, and open gap distance of lips were measured. Follow-up patient satisfaction surveys were conducted from 2 to 3 weeks. Results: Proportion of lower face was significantly changed that the ratio of upper and middle 1/3 were decreased (5.26%, 3.85%) and the ratio of lower 1/3 was increased (8.33%). Modified Legan’s angle was significantly decreased (37.4±16.5%). Open gap distance between lips was decreased (66.2±17.9%) and dry mouth was significantly decreased. Lower facial contour was changed from round shape to elliptical shape and mouth looked smaller and less protruded. Upper lip was everted, but lower lip was inverted. Perioral wrinkles, labio-mandibular folds, and mental dimples were significantly decreased. There was no significant incidence of common complications including chin ptosis. Conclusion: Subperiosteal filler injection is easy, safe and effective in improvement of small chin and interestingly, showed additional beneficial effects such as improvement of dry mouth, lips contour, and perioral wrinkles.
Serous Borderline Tumor of the Paratestis

We report the clinical, morphologic, immunophenotypic, and ploidy findings of seven cases of serous borderline tumor of the paratestis. Mean patient age was 56 years (range, 14–77 years), and the clinical presentation was that of a testicular mass. Tumors ranged in size from 1 to 6 cm (mean, 3.5 cm). Six tumors arose from the tunica albuginea, and two of these tumors were intratesticular. One tumor arose from the tunica vaginalis. Serous borderline tumor of the paratestis is histologically identical to its ovarian counterpart. The tumors were cystic with numerous intracystic blunt papillae lined by stratified epithelial cells with minimal to mild cytologic atypia. Psammoma bodies were present in two cases. In all cases, the neoplastic cells stained strongly and diffusely for cytokeratin 7, estrogen receptor, and CD15, and six of seven cases were positive for progesterone receptor and MOC-31. The cells did not stain for cytokeratin 20, carcinoembryonic antigen, calretinin, and HER2/neu. Proliferative activity, as assessed by MIB-1 staining, ranged from 1.3% to 10% (mean, 5.5%). Five of six tumors were diploid, and one was tetraploid. Patients were treated by radical orchiectomy and followed up from 4 months to 18 years (mean, 48 months; median, 8.5 months). No recurrences or metastases occurred. Serous borderline tumor of the paratestis is morphologically and immunophenotypically identical to ovarian serous borderline tumor. To date, no serous borderline tumor of the paratestis reported in the literature or in our series has recurred or metastasized after resection.
Clinical trials using molecular stratification of pediatric brain tumors

Brain cancer is now the leading cause of cancer death in children and adolescents, surpassing leukemia. The heterogeneity and invasiveness of pediatric brain tumors have historically made them difficult to treat. Although surgical intervention and standard of care therapies such as radiation and chemotherapy have improved the outlook for those affected, results are often transient and lend themselves to tumor recurrence or resistance. There also still exists a subset of brain tumors which remain unresponsive to treatment altogether. Therefore, there is great need for new therapeutic approaches. With the recent advent of molecularly-driven technologies, many of these complex tumors can now be classified by integrating molecular profiling data with clinical information such as demographics and outcomes. This new knowledge has allowed for the molecular stratification of pediatric brain tumors into distinct subgroups and the identification of molecular targets, which is changing how these children are treated, namely in the setting of clinical trials. Notable examples include reduced doses of radiation and chemotherapy in the wingless-activated subgroup of medulloblastoma, which has a favorable prognosis, and novel experimental drugs targeting BRAF alterations in low-grade gliomas and dopamine receptors in high-grade gliomas. In this review, we highlight several key previous and ongoing clinical trials that utilize molecular stratifications and targets for the treatment of pediatric brain tumors.
Synergies between a U . S .-based Electron-Ion Collider and the European research in Particle Physics Contact Persons :

This document is submitted as input to the European Strategy for Particle Physics Update (ESPPU). The U.S.based Electron-Ion Collider (EIC) project recently received strong endorsement by the U.S. National Academies of Sciences, Engineering, and Medicine, bringing its realization another step closer. A large group of European scientists is already involved in the EIC project. Currently, more than a quarter of the EIC User Group (consisting of over 800 scientists) is based in Europe. This European involvement is not only an important driver of the EIC, but can also be beneficial for a number of related ongoing and planned particle physics experiments at CERN. In this document, the connections between the scientific questions addressed at CERN and at the EIC are outlined, as well as the shared interest regarding detector R&D. The aim is to highlight how the synergies between the European Particle Physics research and the EIC project offer ample opportunities to foster progress at the forefront of collider physics. : Van Swinderen Institute for Particle Physics and Gravity, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands email: d.boer@rug.nl : INFN Sezione di Pavia, via Bassi 6, I-27100 Pavia, Italy email: marco.radici@pv.infn. it : with contributions from E. Aschenauer, S. Dalla Torre, M. Diehl, T. Lappi, T. Ullrich, and Yuxiang Zhao; and with useful comments and remarks from F. Bossu, A. Bressan, A. Deshpande, C. Hyde, K. Kumar, H. Montgomery, H. Moutarde, F. Sabatié, G. Schnell, E. Sichtermann, M. Winn, and R. Yoshida.