Miracle-dz/UniFAR-FTUs huggingface dataset:
The Motor Deficit in Patients with Cerebral Palsy

hand, though apparently 36 children in the sample had catastrophic rage bursts as a prominent feature, this is considered to be a peculiar general biological reaction of an intermittent kind to frustrating situations in braindamaged people, rather than a peculiarity of 'temporal lobe epilepsy'. 'Many of the children in this sample were academic failures in spite of good intelligence. ' This appears to be a very interesting point, and it is somewhat tantalizing that very little further information may be found in the rest of the book on this subject. It is interesting, however, that the authors state that intelligence as measured by tests was a poor predictor of schooling success and work record. Amongst the 100 cases, in the 12th chapter, it is mentioned that only two patients had a disorder which was probably genetically determined (phenylketonuria in one case and tuberose sclerosis in the other). It is difficult to understand how, in these cases for example, the evidence of 'temporal lobe epilepsy' was reached. However, it is very interesting to note on page 125 that 'one third of all children who develop temporal lobe epilepsy seem to derive their lesions from severe febrile convulsions occurring in early life'. If this statement is confirmed by other well-documented series of children, it would change considerably the paediatrician's view of 'febrile convulsions'. However, it all depends on what one calls 'febrile convulsions'. This nice little book, with the occasional quotation from Hippocrates, or Ovid, is completed by 21 pages of references (with many notable ommissions including those of Penfield and Jasper's book, of Gastaut, and, in this country, the early work of Hill, of Falconer, of Margerison and others). A useful index of 5 pages completes this elegantly produced book which the reviewer found extremely clear in the printing and illustrations. At the end of the book the reader might wonder why the term 'temporal lobe' should have been included in the title of this book, rather than omitting it altogether and calling it 'Biological Factors in 100 Patients with Epilepsy'.
NEUROPROTECTIVE EFFECTS OF GINGER AGAINST SERTRALINE AS ANTIDEPRESSANT DRUG-INDUCED LESIONS IN SPINAL CORD OF MICE -

Sertraline is an antidepressant drug used for treatment of depression. However, there are several side effects occurred during its use in treatment. Ginger is a natural substance which has many biological effective roles such as immunomodulatory, antioxidant, and free radical scavenging and anti-inflammatory agent. The study was designed to clarify the histological, ultrastructural and immunohistochemical alterations in the spinal cord of male albino mice after ingestion of sertraline and to elucidate of the protective role of ginger extract against the side effects of this antidepressant drug. Forty adult male albino Wister mice were divided into four groups ; group 1 ingested distilled water , group 2 ingested 50 mg/l (10%) ginger extract, group 3 ingested sertraline (0.13 mg/kg/BW), group 4 ingested sertraline and then was given ginger extract after 1 hour. All groups were treated for 28 consecutive days. The animals were sacrificed and the cervical region of the spinal cord from each animal was taken and processed for both light and electron microscopic examinations. Histopathological and ultrastructural studies revealed significant alterations in the motor and sensory neurons of the spinal cord after treatment with sertraline. These changes were confirmed by the immunohistochemical expression results. Sections of animals treated with sertraline followed by ginger revealed marked ameliorative effects. It is concluded that ginger has a protective effect by avoiding the side effects of the sertraline.
The retina in cystic fibrosis

Cystic fibrosis (CF) is caused by defective function of CF Transmembrane Conductance Regulator (CFTR), an epithelial ion channel that facilitates chloride secretion. Previous research has identified impaired dark adaptation (DA) in CF, which has been attributed to concomitant vitamin A deficiency or CF-related diabetes (CFRD). However, CFTR has been localised to the retinal pigment epithelium (RPE) and it is proposed that abnormal DA could be a primary manifestation of CF. DA is similarly impaired in individuals with type 1 and 2 diabetes and is thought to be caused by retinal hypoxia as oxygen inhalation ameliorates abnormal thresholds. The aim of this thesis was to investigate DA during oxygen inhalation in CF subjects with and without CFRD to gain further insight about the aetiology of this abnormal DA. The work also aimed to examine retinal structure using optical coherence tomography (OCT) to determine the consequences of CFTR dysfunction at the RPE. Final DA thresholds were not impaired in CF subjects as a whole during the inhalation of air. However, when grouped according to diabetic status, CFRD subjects showed a significantly elevated final rod threshold which was ameliorated following oxygen inhalation. This suggests that the retina is hypoxic in CFRD subjects and that impaired DA in CF is secondary to CFRD rather than a primary manifestation of CFTR malfunction at the RPE. Contrary to the proposed hypothesis, retinal and RPE/photoreceptor layer thickness was significantly thinner in CF subjects. These results suggest that impaired CFTR function at the RPE does not directly affect retinal structure. · In conclusion, this is the first study to determine that retinal structural and functional abnormalities are not caused directly by CFTR dysfunction but are a secondary manifestation of the disease. Further research is necessary to understand the impact of these findings.
Clarke's analysis of drugs and poisons in pharmaceuticals, body fluids and postmortem material

This manual and reference work provides a source of analytical data for drugs and related substances. It is intended for scientists faced with the difficult problem of identifying a drug in a pharmaceutical product, in a sample of tissue or body fluid, from a living patient or in post-mortem material. Volume One contains 32 chapters covering the practice of and analytical procedures used in forensic toxicology. Volume Two contains over 1750 drug and related substance monographs detailing: physical properties; analytical methods; pharmacokinetic data; and toxicity data, as well as expanded indexes and appendices. These volumes should be useful for all forensic and crime laboratories, toxicologists and analytical chemists, pathologists, poison information centres and clinical pharmacology departments.
Ätiologie, Pathophysiologie und Diagnose der septischen Peritonitis

Zusammenfassung Die septische Peritonitis ist eine Entzündung des Peritoneums, die als Folge einer mikrobiellen Kontamination auftritt. Dieser klinisch bedeutsamen Erkrankung liegt ein sehr umfangreiches Spektrum klinischer Ursachen zugrunde. Sie ist mit einer hohen Morbidität und Mortalität aufgrund eines sekundären Multiorganversagens verbunden. Der vorliegende Artikel stellt Ätiologie, Pathophysiologie und Diagnose dieser Erkrankung beim Kleintier dar. In einem folgenden Beitrag werden Therapie und Prognose beschrieben.
Koagulatorische Aktivität der Thrombozyten

Zusammenfassung Hämostase ist die konzertierte Aktion von Blutkomponenten, um Blutverlust bei Verletzung von Blutgefäßen zu verhindern. Thrombose stellt die Kehrseite dieses physiologischen Prozesses dar, d. h. , fehlgeleitet läuft eine hämostatische Reaktion an einer krankhaft veränderten Gefäßwand ab. Durch hämodynamische Kräfte werden die Thrombozyten in eine wandnahe Grenzschicht gedrängt und strömen entlang des Endothels auf der Suche nach Defekten. Wird eine Verletzungsstelle entdeckt, kommt es zur sofortigen Anlagerung der Thrombozyten, die mit der initialen Abbremsung und Adhäsion durch Glykoprotein(GP)-Ibα-Rezeptorbindung an von-Willebrand-Faktor (VWF) beginnt. GPIb benötigt keine Stimulierung im Gegensatz zu den nachfolgend durch „outside-in“ und „inside-out signalling“ aktivierten weiteren Rezeptoren wie Integrin αIIbβ3 (GPIIb/IIIa), Integrin α2β1, GP VI. Letztere binden an ihre entsprechenden Liganden wie VWF, Fibrinogen, Kollagen und andere subendotheliale Proteine. An dem ersten Rasen haftender Thrombozyten kommt es durch VWF vermittelt zu weiterer transienter Plättchenanlagerung, die durch Fibrinogenbrückenbildung zwischen Integrin-αIIbβ3-Rezeptoren auf benachbarten Plättchen gefestigt wird. Solche Aggregate stellen eine große Masse an prokoagulatorischen Membranen dar, an deren Oberflächen Gerinnungsfaktoren komplexiert und aktiviert werden. Damit läuft die Fibrinpolymerisation um ein Vielfaches beschleunigt ab. Zusätzlich besitzen Thrombozyten mRNA zur schnellen Produktion von TF (tissue factor), dem effektivsten Trigger der extrinsischen Gerinnung. Die entstandenen Fibrinfasern stabilisieren die Thrombozytenaggregate gegen Abriss durch Scherkräfte. Aus Thrombozyten unter hohen Scherraten durch GPIb-VWF-Interaktion entstandene Mikropartikel weisen ebenfalls aktivierte Membranen auf, wodurch es in Koagulationstests zu einer Verkürzung der Gerinnungszeit kommt. Somit scheinen Thrombozyten und thrombozytäre Mikropartikel nicht nur bei der Fokussierung der hämostatischen Antwort auf die Verletzungsregion sondern auch bei der Initiierung und Beschleunigung der nachfolgenden Gerinnung eine wesentliche Rolle zu spielen.
A STUDY ON MODIFIED ALVARADO SCORING SYSTEM IN DIAGNOSING ACUTE APPENDICITIS

Aim: To study the role of Modified Alvarado scoring system in diagnosing acute appendicitis in clinical practice. Materials and Methods: A prospective study was conducted on 250 patients admitted with abdominal pain suggestive of acute appendicitis and were operated, from January 2008 to December 2009 in AVMC&H and MAPIMS. Both males and females patients from 8 years to 60 years of age were included. Preoperative modified Alvarado score was used in all, and the results were compared with operative finding and biopsy. Results: 155 patients were identified to have score of 8 or more. 149 patients were confirmed by biopsy. 91 patients have score 5 -7 and 66 were confirmed by biopsy. Conclusion: This scoring system is a reliable and diagnostic modality to increase the accuracy in diagnosing appendicitis.
RESPONSE LETTER TO DR. INOUYE ET AL.

no or minimal effectiveness for delirium. In summary, given the substantial methodological limitations of the Vidán study, the conclusions are erroneous and misleading. Their intervention is not effective in prevention of delirium. The take-home message from this article is that watering down the proven HELP intervention strategy is inefficient and ineffective. In this era of relentless cost-cutting and quick fixes, this study provides yet another example to bolster the well-known truth, stated by George Washington Carver . ‘‘There is no shortcut to achievement. ’’
Strategic Marketing for Educational Institutions

Strategic Marketing Issues in Emerging MarketsManagement and Leadership of Educational MarketingFast forwarding Higher Education Institutions for Global ChallengesDemographics and the Demand for Higher EducationStrategic Marketing for Educational InstitutionsStrategic Marketing of Higher Education in AfricaSocial Media in Higher Education: Case Studies, Reflections and AnalysisGlobalization of Management EducationNew Age Admissions Strategies in Business SchoolsStrategic Marketing in the Global Forest IndustriesStrategic Marketing for Educational InstitutionsHow to Market a UniversityMarketing Strategies for Higher Education Institutions: Technological Considerations and PracticesStrategic Marketing for Educational InstitutionsReliability and Statistics in Transportation and CommunicationIndonesia Privatization Programs and Regulations Handbook Volume 1 Strategic Information and RegulationsSpace MarketingSTRATEGIC MARKETING : MAKING DECISIONS FOR STRATEGIC ADVANTAGE, SECOND EDITIONEBOOK: Marketing Higher EducationThe Ultimate Guide to School Marketing StrategiesStrategic Brand Management in Higher EducationEducational MarketingStrategic Marketing for Nonprofit OrganizationsBecoming A Digital Marketer: Gaining the Hard & Soft Skills for a Tech-Driven Marketing CareerInternational Marketing of Higher EducationAn Examination of Integrated Marketing Communication in U.S. Public Institutions of Higher EducationDemocratizing InnovationEducational ManagementThe Strategic Management of Higher Education InstitutionsThe College Stress TestManaging External Relations in Schools and CollegesChoosing FuturesStrategic Management in Schools and CollegesInstaBrainOpening Up EducationGlobalization and Internationalization in Higher EducationVisual Thinking StrategiesMarketing Techniques for Educational ProgramsCorporate Governance and Strategic Decision MakingHow to Market a University
Selectividad: criterio de diseño para reacciones complejas

The gangliosides are glycosphingolipids that are distributed in the organism in different forms. The presence of the ganglioside N-Glycolil GM3 (NGcGM3) has been described in human tumoral cells, that is why it has became an attractive target for the specific antitumoral therapy. This molecule is the main component of the vaccine candidate for breast cancer in clinical trials phase. Lactose acceptor is a key intermediate to obtain this ganglioside by chemical synthesis, the protection of the positions 3´,4´ of lactose with an isopropiliden group is necessary in the synthesis of lactose acceptors that will be used to form part of oligosaccharides and glycoconjugates. This work is focused in the reaction to obtain 3',4'-lactose-isopropiliden, an intermediate in lactose acceptor synthesis. The reaction conditions were studied and the best results were found working at +1 level of temperature and -1 level of time reaction. The reaction was made in a 5 L reactor and the results were reproducible. The thin layer semi-quantitative chromatography was chosen to quantify the amount of the isomers 3´,4´ and 4',6'-lactose isopropiliden obtained in the reaction.
Bifeprunox: A partial dopamine-receptor agonist for the treatment of schizophrenia

Schizophrenia is a chronic psychiatric disorder that affects an estimated 1% of the population. This disorder may be treated with typical (first-generation) or atypical (second-generation) agents; a recognized concern regarding these agents is that long-term use has been associated with increased risks of serious side effects, either neurologic or metabolic in nature. Bifeprunox is a partial dopamine-receptor agonist under investigation for the treatment of patients with schizophrenia.If approved, bifeprunox may serve as an additional option for the acute and maintenance treatment of schizophrenia.
Type D personality across general population and coronary patient samples in Iceland : Implications for cardiovascular health

ter verkrijging van de graad van doctor aan Tilburg University op gezag van de rector magnificus, prof.dr. Ph. Eijlander, in het openbaar te verdiedigen ten overstaan van een door het college voor promoties aangewezen commissie in de aula van de Universiteit op donderdag 15 november 2012 om 16.15 uur
Pancreatic Cancer: Review of Etiology, Clinical Features, Diagnostic Procedures, Treatment and Mesothelin Role

Pancreatic cancer is one with high mortality cancer in the world. Ninety percent of pancreatic cancer is pancreatic adenocarcinoma. Various factors is associated with an increased risk of pancreatic cancer including age, sex, race, genetic, history of chronic pancreatitis, diabetes mellitus, gallstone, obesity, Helicobacter pylori infection, smoking, diet, and polution exposure. A lot of cases were diagnosed in late stadium due to non-specific early clinical symptoms, and also, until now, there is no examination tool that may screen pancreatic cancer in the earliest stage. Total surgery resection is the therapy of choice in the early stadium of pancreatic cancer, and other therapy modalities are chemotherapy, radiotherapy. Combination of these modalities is frequently used in order to increase the effectiveness of therapy. Mesothelin, a surface glycoprotein on normal mesothelial cells, is overexpressed in pancreatic cancer; therefore, although it is not a cancer specific antigen, it can be used in diagnostic and treatment of pancreatic cancer. Several studies about mesothelin application in pancreatic cancer have been performed; however, more studies are needed to improve the application of mesothelin on pancreatic cancer. Keywords : pancreatic cancer, risk factor, therapy, mesothelin
Resultados de un Proyecto de Arranque en la Implementación del Gobierno de las Tecnologías de la Información en universidades de Colombia

Resumen. Un buen sistema de Gobierno de TI en una universidad concebirá a las TI no solo como elementos tácticos, sino que hará parte de la planificación global de la universidad generando una nueva cultura donde se podrá extraer de las TI el máximo valor posible para la universidad. Este artículo presenta un proyecto de arranque en la implementación del gobierno de las TI en universidades de Colombia tomando como caso piloto la Corporación Universitaria Comfacauca donde se socializará los resultados obtenidos en este proceso. En primera instancia se describe el proyecto al lado de una metodología propuesta aplicada a la universidad, se presentan las evidencias de buenas prácticas relacionadas con el Gobierno de las TI, seguidamente se identifica la madurez inicial y objetivos de mejora del Gobierno de las TI y finaliza presentando un Plan de mejora del Gobierno de las TI.
Central Nervous System Involvement in a Child with Human Immunodeficiency Virus Infection: A Case Report

HIV has infected 4.4 million children worldwide and has resulted in 3.2 million deaths. The progression of vertically acquired HIV infection appears to have a trimodal distribution. Approximately, 15% of children have rapidly progressive type of disease, while the remainders have either a chronic progressive course or an infectious pattern typical of that in adults. Mean survival is about 10 years. Children can be asymptomatic for many years, and the appearance of an opportunistic infection in a 10-year-old child in whom AIDS is subsequently diagnosed is not rare. Neurologic findings in an infected child are: Motor delay, hypotonia, hypertonia, and/or pyramidal tract signs which may indicate progressive HIV encephalopathy or opportunisic infection of the CNS. Our case was an 8-year old boy presented with fever, vomiting, and loss of consciousness.The patient was a known case of HIV infection due to mother’s infection in perinatal period and was on treatment from 3 years before his referral. He was presented to our hospital for the fever which had started one month earlier and refractory vomiting. The patient got in coma on the chest examination; tachypnea, crackles and heart murmur were auscultated. In neurologic examination, anisocoria, right-sided hemiparesis, increased deep tendon reflexes in the right side and extensor plantar reflex, Kernig and Brudzinski signs were detected. Eventually, the patient died after 46 days of hospitalization in pediatric intensive care unit because of full sepsis.
FATORES ASSOCIADOS À CRONOLOGIA DE ERUPÇÃO DE DENTES DECÍDUOS - REVISÃO DE LITERATURA: Erupção de dentes decíduos e fatores associados doi: http://dx.doi.org/10.5892/RUVRV.91.139151

The purpose of this review of the literature was to investigate the factors that influence chronology of the eruption of the deciduous teeth. A literature survey was done in PubMed and Google Scholar, considering the period from January 1956 to December 2010. It was used as descriptors "nutritional status and eruption of deciduous teeth," changes in the eruption of deciduous teeth, "malnutrition and eruption of deciduous teeth, premature birth and eruption 1 Acadêmica do curso de graduação em Odontologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brasil. mariaeqd_col@yahoo.com. br 2 Acadêmica do curso de graduação em Odontologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brasil.mayraodontologia@gmail.com 3 Mestranda em Odontopediatria, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brasilpatrícia. faria08@yahoo.com. br 4 PhD, Professor de Ortodontia, Universidade do Vale do Rio Verde, Departamento de Ortodontia, Três Corações, Minas Gerais, Brasil – lsmarques.prof@gmail.com 5 PhD, Professora Adjunto de Odontopediatria, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brasil mlramosjorge@gmail.com doi: http://dx.doi. org/10.5892/RUVRV.91. 139151
Movement Awareness and Communication in Patient Transfer -an Educational Intervention

Background: This thesis addresses patient transfer, i.e., assisting the physical movement of patients with disabilities. Patient transfer is the primary cause of workrelated disorders in healthcare providers. It has mainly been viewed as a physical work task, although the providers’ own movement awareness and communication skills may be as important to support the patient to mobilise remaining resources. In response to this, Natural Mobility has been developed as an experiential educational method in patient transfer, inspired by physiotherapists’ tacit knowledge. The aim of the education is to create a learning environment where healthcare providers can train body and movement awareness and communication skills to be able to guide the patient to move independently. Aim: The overall aim of the thesis was to explore and evaluate healthcare providers changes in patient transfer after participation in Natural Mobility regarding type and number of changes and the sustainability of the changes. Methods: In total, 462 healthcare providers from health facilities (nursing homes, hospitals) in different municipalities and county councils in Sweden were recruited voluntarily to the studies. The intervention consisted of a course in Natural Mobility. Study I (n=212), used a pre-post design; Study II (n=20) was an interview study, and in Study III (n=250) and IV (n=192) a quasi-experimental pre-post design with control groups was used. Outcome was measured with both quantitative (questionnaires) and qualitative (interviews, weekly notes) methods Results: About two thirds (68%) of the providers had changed something in their transfer habit after a year. They also reported less strain and higher work satisfaction (Study I). The reasons for changes seemed to be related to whether the provider focused the patient, their own body or the communication with the patient (Study II). Providers’ perceived strain and reported disorders decreased one year after the education, while their movement awareness increased, and they gave more detailed instructions (Study III). The communication mode with the patient, changed in some providers from a physical to a more verbal mode. The providers described the patients performance instead of their own (Study IV). This was in line with the course content. Conclusion: Participation in training in patient transfer according to the Natural Mobility method can enable some healthcare providers to increase their movement awareness and communication skills to support patients’ independent movements during transfer, and thereby also reduce physical strain and disorders. More research is needed to fully understand the role of communication in patient transfer and how training can be optimised.