Miracle-dz/UniFAR-FTUs huggingface dataset:
Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice

Members of the signal transducers and activators of transcription (Stat) family regulate essential cellular growth and survival functions in normal cells and have also been implicated in tumorigenesis. We have studied the potential role of Stat5 in mammary tumorigenesis by targeting Stat5 variants to the mammary gland of transgenic mice using regulatory sequences of the β‐lactoglobulin gene. Mammary‐directed expression of the wild‐type Stat5, constitutively activated Stat5 and carboxyl‐terminally truncated dominant negative Stat5 forms resulted in mammary tumors with incidence rates of up to 22% and latency periods of 8–12 months. Undifferentiated carcinomas most frequently occurred in mice expressing the carboxyl‐terminally truncated Stat5. The more differentiated papillary and micropapillary adenocarcinomas were primarily found in mice overexpressing the native and constitutively active transgenes. Higher levels of translation initiation factor 4E (eIF4E) and cyclin D1 expression but lower levels of activated Stat3 were found in tumors of mice expressing the constitutively active Stat5 when compared to mice expressing the wild‐type or truncated forms. A higher expression of the estrogen receptor (ERα) was observed in carcinomas compared to other phenotypes. The ability of both forms of Stat5, the transactivating form and the dominant negative form, to participate in oncogenesis indicates that there is more than one mechanism by which Stat5 contributes to this process. The transactivation function of Stat5 is involved in the determination of tumors with a more differentiated phenotype. © 2004 Wiley‐Liss, Inc.
The Effect of Local Injury to the Endometrium for Implantation and Pregnancy Rates in ICSI -ET Cycles with Implantation Failure: a randomised controlled study

To assess the effect of local injury to the endometrium for implantation, pregnancy and live birth rates in ICSI –ET cycles with recurrent implantation failure. The study was prospectively designed and performed in a university hospital. A group of 100 women, who failed to conceive during one or more cycles of IVF and embryo transfer (ET), was treated with a long protocol for controlled ovarian hyperstimulation. The IVF treatment and ET were preceded by repeated endometrial biopsies, in a randomly selected 50 of a total of 100 women. Age of the women, days of stimulation, total dose of gonadotropins, E2 concentrations and endometrial thickness on hCG day, total MII stage oocytes, the total number of high quality embryos for transfer, the day of transfer and the number of embryos transferred were similar for both groups. Transfer of a similar number of embryos (138 and 141 in the experimental and control patients, respectively) resulted in rates of implantation (34.67 % vs. 30.88 %; p= 0,1384) clinical pregnancy (60 % vs. 34 %; p= 0.009), and live births per ET (44 % vs. 24 %; p= 0.03), which were higher in the experimental group as compared to controls. These results suggest that IVF treatment that is preceded by local injury to the endometrium improved the rates of embryo implantation, clinical pregnancy, and live births in asiste reproductive technique.
Evaluation of enantioselective binding of antihistamines to human serum albumin by ACE

The drug binding to plasma and tissue proteins is a fundamental factor in determining the overall pharmacological activity of a drug. HSA, together with α1‐acid glycoprotein, are the most important plasma proteins, which act as drug carriers, with implications on the pharmacokinetic of drugs. Among plasma proteins, HSA possesses the highest enantioselectivity. In this paper, a new methodology for the study of enantiodifferentiation of chiral drugs with HSA is developed and applied to evaluate the possible enantioselective binding of four antihistamines: brompheniramine, chlorpheniramine, hydroxyzine and orphenadrine to HSA. This study includes the determination of affinity constants of drug enantiomers to HSA and the evaluation of the binding sites of antihistamines on the HSA molecule. The developed methodology includes the ultrafiltration of samples containing HSA and racemic antihistaminic drugs and the analysis of the free or bound drug fraction using the affinity EKC‐partial filling technique and HSA as chiral selector. The results shown in this paper represent the first evidence of the enantioselective binding of antihistamines to HSA, the major plasmatic protein.
A very high security cryptosystem architecture for video application

This paper presents a very high security cryptosystem architecture that combines strengths of the symmetric key cryptography and the public key cryptography. The symmetric key cryptographic algorithm (ZUC) is used to encrypt/decrypt bulk data while the public key algorithm (RSA) performs the encryption/decryption of the secret key of ZUC. This architecture achieves high security thanks to the ease of key distribution from the public key cryptosystem, key changing during a session. This cryptosystem is implemented in Verilog-HDL, simulated on ModelSim and evaluated using Altera Cyclone IV-based DE2 Development Kit. The throughput of bulk data decryption achieves up to 1.79 Gbps at the operating frequency of 56 MHz, which satisfies applications with high bandwidth requirement such as video.
Characterization of Binding Affinity of CJ-023,423 for Human Prostanoid EP4 Receptor

In order to characterize the receptor binding pharmacology of CJ-023,423, a potent and selective EP4 antagonist, we performed a radioligand receptor binding assay under various assay conditions. An acidic (pH 6) and hypotonic buffer is a conventional, well-known buffer for prostaglandin E2 receptor binding assays. CJ-023,423 showed moderate binding affinity for human EP4 receptor under conventional buffer conditions. However, its binding affinity was greatly increased under neutral (pH 7.4) and isotonic buffer conditions. In this report, the binding mechanism between CJ-023,423 and human EP4 receptor is discussed based on the binding affinities determined under various assay conditions.
Development of an instrument to measure exercise of self-care agency.

The purpose of this study was to develop an instrument to measure a person's exercise of self-care agency. Reliability and validity were established. Content validity was established through a rating of each item of the questionnaire by five nursing experts practicing under the self-care concept. The Adjective Check List and Rotter's Internal-External Locus of Control of Reinforcement Scale were used in establishing construct validity. Subjects consisted of 84 associate degree nursing students and 153 psychology students. Results showed (a) a positive correlation of self-confidence, achievement, and intraception with exercise of self-care agency and (b) a negative correlation between abasement and exercise of self-care agency. The test-retest reliability was . 77 for the nursing students; split-half reliabilities were . 80 and . 81, respectively, for the first and second testings of the nursing students, and . 77 for the psychology students.
Contexto y determinantes funcionales de la Clasificación documental

La operacion de clasificar es examinada en el contexto de la cadena documental. La clasificacion se define como una metodologia heuristica, que esta siendo mejorada por la aplicacion del metodo cientifico. Se considera una operacion de indizacion, mediante la cual cada documento se situa en una ordenacion sistematica, en la cual recibe un lugar predecible, y, por ello, puede ser recuperado eficazmente. La operacion de clasificar aparece determinada por cuatro factores: a) la estructura del mundo de los documentos, una funcion a su vez de la estructura del mundo del conocimiento; b) los sistemas de clasificacion que nos permiten codificar esas estructuras; c) el modo en que la gente construye y usa las clasificaciones; y d) las caracteristicas de la unidad de informacion. (Autor)
ECPC: el discurso parlamentario europeo desde la perspectiva de los estudios traductológicos de corpus

Este articulo presenta la labor investigadora del grupo ECPC, que ha disenado y creado un Archivo de discursos parlamentarios europeos con el fin de estudiar dicho genero y la hipotetica influencia de la traduccion en la construccion de la identidad europea. La investigacion se ha restringido al Parlamento Europeo (mediante la construccion de un corpus paralelo —EN y ES— con las versiones en ingles y espanol) y a dos parlamentos nacionales, la House of Commons britanica (HC) y el Congreso de los Diputados espanol CD), que constituyen sendos corpus comparables. El Archivo contiene los discursos recogidos en las actas de las sesiones plenarias celebradas a lo largo de la VI legislatura del Parlamento Europeo (2004-2009) en cada una de las camaras anteriormente mencionadas.
Latency of auditory evoked M100 as a function of tone frequency

THIS study investigated post-stimulus latency of the M100 component of auditory evoked fields as a function of tone frequency. A 37-channel biomagnetometer was used to record neuromagnetic fields over the temporal lobe in response to monaurally presented tones. M100 peaks in evoked field amplitude were found for each subject. The post-stimulus latency was observed to vary parabolically with tone frequency. Latencies as short as 99ms were found in response to mid-audio range frequencies (1000–2000 Hz), whereas lower (100–500 Hz) and higher (3000–5000 Hz) frequencies were associated with longer latencies (up to 153 ms). All fields gave M100 dipole localizations in auditory cortex. Although it was not possible to resolve spatial tonotopy, it appears that frequency information is encoded in the temporal evoked response.
Predicting Falls: The Role of Mobility and Nonphysical Factors

Our purpose was to test a four‐domain predictive model of recurrent falls developed for this study. In this model, limited mobility is considered a necessary but not sufficient element in risk of recurrent falls. Three other domains, attitudinal, social, and environmental, are proposed to influence fall risk only in persons with impaired mobility.
Analysis of thermal coupling effects in integrated MIMO transmitters

This paper presents a detailed analysis of thermal coupling and self-heating effects in highly integrated wireless transmitters. A MIMO transmitter prototype consisting of two closely integrated power amplifiers was built and modelled through microwave and thermal characterizations. The thermal behavior was extracted using FEM software and modelled with an equivalent RC network. The PA model was obtained experimentally using a pulsed setup. An RF-thermal simulator was developed and used with the models to predict joint thermal and electrical behavior. Measurements with modulated communication signals were done and compared with the simulator to demonstrate its feasibility for analysis of thermal effects in highly integrated transmitter applications.
Interruption Practice Reduces Errors

Abstract : Mitigating the effects of interruptions is important for tackling the increasing number of possible disruptions at home, at work, and online. Previous work has shown that the benefits of practice can decrease the amount of time it takes to resume a task after an interruption. This paper demonstrates that the same benefit can be extended to error rates at the post-completion step showing that a general increase in interruptions leads to a decrease in error rates for the last step of a form-filling task.
A regulatory role for cortisol in muscle glycogen metabolism in rainbow trout Oncorhynchus mykiss Walbaum

SUMMARY To test the hypothesis that cortisol has a regulatory role in fish muscle glycogenesis post-exercise, rainbow trout were treated 1 h prior to exercise with either saline (control) or metyrapone (2-methyl-1, 2-di-3-pyridyl-1-propanone) to block cortisol synthesis. Following exercise (time 0), half of the metyrapone-treated fish received a single injection of cortisol, to mimic the post-exercise rise usually observed. Muscle glycogen and the relative activities of glycogen phosphorylase a (Phos a) and glycogen synthase I (GSase I), regulatory enzymes for glycogen resynthesis, were monitored 4 h post-exercise. Metyrapone treatment succeeded in blocking the post-exercise rise in plasma cortisol (17±2 vs 118±13 ng ml–1 in controls at time 0), and cortisol injection resulted in a larger and more prolonged cortisol increase than in controls (159±22 vs 121±14 ng ml–1 in controls at 1 h). Muscle glycogen was completely restored in the metyrapone-treated fish within 2 h after exercise (8.3±0.6 vs 8±0.7 μmol g–1 pre-exercise), only partially restored in control fish at 4 h (5.4±01.4 vs 8.8±1.3 μmol g–1 pre-exercise), and not at all in cortisol-treated fish (1.0±0.5 μmol g–1 at 4 h). The rapid glycogen resynthesis in the metyrapone-treated fish was associated with a more rapid inactivation of Phos a and stimulation of GSase I compared to controls. In cortisol-treated fish, Phos a activity persisted throughout 4 h post-exercise; there was also a significant stimulation of GSase I activity. As a consequence of dual activation of Phos a and GSase I, glycogen cycling probably occurred, thus preventing net synthesis. This explains why the post-exercise elevation of cortisol inhibits net glycogen synthesis in trout muscle.
Electrocardiography-Gated Computed Tomography of the Bronchial Arteries With Iterative Image Reconstruction: Clinical Evaluation and Image Quality

Background The aim of this study was to apply electrocardiography (ECG)-gated prospective-triggered multidetector row computed tomography angiography with iterative model reconstruction (IMR) to optimize imaging of the bronchial arteries in patients with the chief complaint of hemoptysis. Methods This was a prospective observational study. Between August 2015 and June 2016, we enrolled 31 consecutive patients with the chief complaint of hemoptysis who were scheduled to undergo computed tomography of the bronchial artery. Patients were randomly divided into 3 groups: group A, with filtered back-projection reconstruction; group B, with iDose reconstruction; and group C, with ECG-gated prospective-triggered multidetector row computed tomography angiography with IMR. Image quality, visibility, and traceability were compared. Results Image quality, including signal-to-noise and contrast-to-noise ratios, visibility, and traceability, was best in group C. Conclusions With the help of IMR and ECG-synchronized prospective-triggered technology, the bronchial artery anatomy can be accurately depicted in patients with massive hemoptysis.
PREDICTORS OF PSYCHOSOCIAL DISTRESS AFTER SUICIDE, SIDS AND ACCIDENTS

This article compares the outcome and predictors of psychosocial distress of parents bereaved by young suicides, sudden infant death syndrome (SIDS), and child accidents. One objective is to explore whether suicide bereavement is more difficult for those left behind than other forms of bereavement. Data have been collected from 140 families, consisting of 232 parents, by the use of the Impact of Event Scale, the General Health Questionnaire, and the Inventory of Traumatic Grief. Qualitative aspects of bereavement are assessed by in-depth interviews with family members from 40 families. The results show that the similarities between the samples on outcome and predictors are more striking than the differences, which is explained by the common traumatic aspect of unexpected and violent deaths. One and a half years post-loss, 57-78% of the survivors scored above the cut-off levels for traumatic grief reactions. Although no significant differences are found between survivors of suicide and accidents, both groups evidence significantly greater subjective distress than the survivors of SIDS. Self-isolation is by far the best predictor of psychosocial distress in all three samples. Rather than focusing on the exceptional position of suicide survivors, it seems important to call attention to sudden and traumaticdeathingeneral as a factor to be associated with post-traumatic reactions and complicated mourning.
An evaluation of dementia screening in the primary care setting

Purpose: To evaluate current screening methods for dementia to determine the most accurate and efficient tools for use in primary care. Data sources: Search included the following: Medline, CINAHL, BIOSIS, PsycINFO, ISI Web of Science, and Health & Psychosocial Instruments (1840–2005). The following search terms were used: screen, screening, tools, Mini Mental, MMSE, clock drawing, subjective memory, assessment, diagnosis, primary care, outpatient, community based, ambulatory care, dementia, cognitive impairment, and memory impairment. There was no limit to publication year. Articles excluded were those not published in English and those which used screening tools as part of diagnostic evaluation. The search revealed 581 relevant articles, which were narrowed to 20. Conclusions: The Mini Mental State Examination (MMSE) has high sensitivity and specificity in outpatients older than 65 years when age‐ and education‐specific cutoffs are used. The clock drawing test has lower sensitivity and specificity when used alone; however, in combination with the MMSE, its sensitivity is higher than that of the MMSE while specificity is slightly lower. Subjective memory complaints contribute diagnostic information; however, objective memory performance is a stronger predictor of future dementia. All measures are subject to influence by age, education, and other physical factors. The body of evidence regarding dementia screening methods has increased in recent years. The studies have been well conducted, of large sample size, in various geographic locations and populations, and by numerous investigators. Implications for practice: Dementing illnesses will become a common presentation in primary care. Currently, routine screening is not conducted although acceptable instruments, such as the MMSE, are available. Additional research on routine screening in primary care to bolster the current evidence, use of nurses as evaluators of cognition, and utilization of specialists is needed.
Eficacia diagnóstica de la cápsula endoscópica en pacientes con sangrado de tubo digestivo medio

Introducción: La cápsula endoscópica es actualmente el estándar de oro para el diagnóstico del sangrado de tubo digestivo de intestino. La cápsula endoscópica es positiva en el 44% a 82% de los pacientes, con sangrado de origen oscuro. Objetivo: Identificar la eficacia diagnóstica de todas las cápsulas endoscópicas colocadas, entre agosto del 2008 y agosto del 2011, por el diagnóstico de hemorragia de origen oscuro evidente y no evidente, no explicada posterior a panendoscopia y colonoscopia. Métodos: A todos los pacientes se les administró la videocápsula Given M2A (Given Imaging, Yoqneam, Israel) con la técnica tradicional. La lectura de la cápsula se realizó a 15 imágenes por segundo, y fueron observadas por dos endoscopistas experimentados. Resultados: A un total de 49 pacientes (25 hombres y 24 mujeres), se les colocó la cápsula endoscópica. Los diagnósticos fueron hemorragia de origen oscuro evidente en 46 casos y anemia en tres pacientes. En total se encontró la causa del sangrado en el 65% de Abstract
Suicide Notes in Adolescence *

Suicide rates for adolescents have shown a substantial increase over the past 30 years, but there is little information regarding the clinical status of adolescents who end their lives. In the adult literature, one avenue to understanding the psychologic condition immediately prior to the self-destructive act has been the study of suicide notes, and the present study constitutes the first systematic investigation of notes left by children or adolescents. Records of death were examined in the Office of the Coroner, City of Montreal, and all suicides between ages 10 and 20 were identified for the years 1978 to 1982. Seventeen individuals who left notes were identified, comprising 10% of the population of suicides. Suicides who left notes did not differ from the total group in age and sex distribution but were more likely to choose shooting as a method. The content of the notes was studied in terms of 11 variables which had proven characteristic of suicide notes in the adult literature, and the results were compared to those reported for adults. In general, our results support a psychoanalytic perspective which understands suicide as resulting from an ambivalent attachment to an object, loss of the object, internalization, and the direction of aggression against the self. Cases appeared to fall into two clusters. Older adolescents were more concrete, left specific instructions, did not address the note, did not give a reason for the act, and tended to choose intoxication as a method. Younger adolescents were less concrete, less likely to leave specific instructions, addressed the note to their parents, explained the act, and chose firearms as the method of self-destruction. Implications for a developmental understanding of suicide are discussed.
A detailed comparison of WSD systems: an analysis of the system answers for the SENSEVAL-2 English all words task

We compare the word sense disambiguation systems submitted for the English-all-words task in SENSEVAL-2. We give several performance measures for the systems, and analyze correlations between system performance and word features. A decision tree learning algorithm is employed to discover the situations in which systems perform particularly well, and the resulting decision tree is examined. We investigate using a decision tree based on the SENSEVAL systems to (i) filter out senses unlikely to be correct, and to (ii) combine WSD systems. Some combinations created in this way outperform the best SENSEVAL system.
Low-energy fracture of posterolateral tibial plateau: Treatment by a posterolateral prone approach

BACKGROUND: Most of the posterolateral tibial plateau fractures are caused by low-energy injury. The posterior fracture fragment could not be exposed and reduced well through traditional approaches. The aim of this study was to review the results of surgical treatment of this kind of fracture using posterolateral approach with patient in prone position. METHODS: The low-energy posterolateral fracture is defined as the main part of articular depression or split fragment limited within the posterior half of the lateral column. Direct reduction and buttress plate fixation through the posterolateral prone approach was applied in all the patients. RESULTS: In our series, 15 of 132 (11.4%) patients with tibial plateau fractures were identified as low-energy posterolateral fractures. The clinical outcomes were available in 14 of the 15 patients through phone interviews and chart reviews. Mean follow-up was 35.1 months (range: 24–48 months). All the patients had anatomic or good reductions (⩽2 mm step/gap). Average range of motion was 0.7 degrees to 123.2 degrees (5–110 degrees to 0–140 degrees). The complications were limited to one superficial wound infection, two slight flexion contractures, and five implants removal. The average modified hospital for special surgery knee score was 93.4 (range: 86–100). CONCLUSIONS: The posterolateral prone approach provides excellent visualization, which can facilitate the reduction and posterior buttress plate fixation for low-energy posterolateral tibial plateau fractures and shows encouraging results. LEVEL OF EVIDENCE: V, therapeutic study.