Miracle-dz/UniFAR-FTUs huggingface dataset:
Studies on Cytochrome P450 genes in Drosophila melanogaster : Relationship between over expression and DDT resistance, and xenobiotic induction

Cytochrome P450 monooxygenases (CYPs), are involved in the metabolism of a diverse group of endogenous and xenobiotic compounds. In insects, CYPs are involved in conferring resistance against insecticides. In Drosophila, the expression of Cyp6a2, Cyp6a8, Cyp6g1, Cyp6w1 and Cyp12d1 is higher in the resistant compared to susceptible strains. Recent study by Daborn et al (2002, Science, 297, 2253-2256) showed that Cyp6g1 alone can confer resistance phenotype. The aim of my first objective was to reexamine this claim and second to examine the effect of common xenobiotic compounds on the transcriptome of Drosophila. In first objective, six strains of Drosophila were examined for DDT resistance and Cyp6g1 expression. Results showed that some of the highly susceptible strains showed high level of Cyp6g1 expression and Accord element in the Cyp6g1 upstream DNA. When Cyp6g1 allele of the resistant 91-R strain was substituted with that of the susceptible 91-C strain via recombination, the resulting three recombinant lines retained high level of resistance like the 91-R strain, but showed very low Cyp6g1 expression. This suggests that there is a correlation between overexpression of Cyp6g1 and the presence of Accord transposable element but not DDT resistance. In the second part of the first objective, I directly examined the role of the Cyp6a2 and Cyp6g1 in DDT resistance. Germ line transformation in susceptible strain showed that there was a two-fold increase in DDT resistance (LD50) in transformed flies showing
A paradigm shift to OOP has occurred…implementation to follow

This paper reflects on the discussions concerning the first year programming sequence that have transpired at the last few national symposiums in Computer Science Education and at other computer education conferences in the past two years. Both paper and birds-of-a-feather sessions suggest that computer science educators are deep into the transition from the procedural to object approach as the preferred basis for the design and implementation of software. This transition has become evident in the introductory textbooks, but it is more evident in the struggles of a faculty that has grown up with structured programming and now has to overcome that deeply entrenched mind-set. The author reflects on the characteristics of this struggle by comparing it to academic worldview struggles that have been termed “paradigm shifts. ” Such struggles have been studied in other scientific disciplines and the pattern observed there is emphasized in the author's interpretation of recent events in computer science education.
Four new species of Hisonotus (Siluriformes: Loricariidae) from the upper rio Uruguay, southeastern South America, with a review of the genus in the rio Uruguay basin

Four new species of Hisonotus are described from the upper course of the rio Uruguay basin in Brazil: Hisonotus iota from the rio Chapeco drainage; Hisonotus leucophrys from rio Rancho Grande and rio Ariranhas; Hisonotus megaloplax from the rio Passo Fundo drainage; and Hisonotus montanus from the rio Canoas drainage. The species Epactionotus aky, described from the arroyo Yaboti-Guazu drainage in Argentina, is transferred to Hisonotus and rediagnosed. Hisonotus candombe is considered a junior synonym of H. ringueleti. The new taxa, together with H. nigricauda, H. ringueleti, H. charrua, and H. aky represent the genus Hisonotus in the rio Uruguay basin. A taxonomic key for Hisonotus in the rio Uruguay basin is provided. Their distributions are discussed under biogeographic patterns previously proposed for the rio Uruguay basin.
Aripiprazol-Depot

Zusammenfassung Das im November 2013 für die Behandlung der Schizophrenie in Europa zugelassene und seit Mitte Juni in Deutschland eingeführte Aripiprazol-Depot Präparat Abilify Maintena® hat sich als wirksames und gut verträgliches Depot-Antipsychotikum erwiesen. Besonders in der Behandlung schizophrener Patienten mit häufig eingeschränkter Compliance sind Depot-Antipsychotika hinsichtlich Rückfallprophylaxe eine wichtige Behandlungsmöglichkeit. Aufgrund des besonderen Rezeptorprofils von Aripiprazol mit partiell agonistischem Wirkeffekt an den D2/D3-Rezeptoren sowie berichteten Wirkvorteilen bei affektiven und kognitiven Beeinträchtigungen stellt die Depotformulierung eine interessante Behandlungsalternative in der Therapie der Schizophrenie dar. Auch das günstige Nebenwirkungsprofil von Aripiprazol mit einem nachgewiesenen niedrigen Risiko für extrapyramidalmotorische Symptome sowie metabolische Nebenwirkungen macht den Stellenwert dieser neuen Depotformulierung deutlich. Die einmal im Monat anzuwendende Injektion ist in zwei unterschiedlichen Dosierungsstufen (300 und 400 mg) erhältlich, in seiner Anwendung einfach handhabbar und wird von den Patienten gut toleriert.
Benefits of Educational Data Mining

We live in a world where we collect huge amounts of data, but if this data is not further analyzed, it remains only huge amounts of data. With new methods and techniques, we can use this data, analyze it and get a great advantage. The perfect method for this is data mining. Data mining is the process of extracting hidden and useful information and patterns from large data sets. Its application in various areas such as finance, telecommunications, healthcare, sales marketing, banking, etc. is already well known. In this paper, we want to introduce special use of data mining in education, called educational data mining. Educational Data Mining (EDM) is an interdisciplinary research area created as the application of data mining in the educational field. It uses different methods and techniques from machine learning, statistics, data mining and data analysis, to analyze data collected during teaching and learning. Educational Data Mining is the process of raw data transformation from large educational databases to useful and meaningful information which can be used for a better understanding of students and their learning conditions, improving teaching support as well as for decision making in educational systems.The goal of this paper is to introduce educational data mining and to present its application and benefits.
The influence of selenium on the level of linoleic acid isomers in incubated ruminal fluid

Ovine ruminal fluids were incubated in vitro at 39°C under CO2 either alone or with a combination of linoleic acid (LA) (1.67 g/l), a low (0.167 μg/ml) or high (1.67 μg/ml) level of selenite (Se(IV)), or selenate (Se(VI)). The high level of Se(IV) resulted in a decrease of CLA isomer accumulation in in vitro incubated cultures with LA. Low and high levels of Se(VI) in ruminal fluids elevated the content of CLA isomers and trans-vaccenic acid in fluids incubated with LA.
Joint 2-D angles and time delay estimation of coherent wideband signals

Joint direction of arrival (DOA) and time delay (TD) estimation of wideband signals such as WIFI and mobile communication signals has to face the challenges aroused by multipath effect in indoor environments. New methods that can deal with coherent wideband signals with high estimation accuracy are necessary. To achieve localization when signals are coherent, this paper proposes a new joint estimation method which fully utilizes the subcarriers of wideband signals. This method could greatly extend the array aperture and accomplish the joint estimation through UCA-ESPRIT and one-dimensional (1-D) search. Simulation experiments are conducted to show the validity and efficiency of this method.
Use of Winter Legumes as Banker Plants for Beneficial Insect Species in a Sorghum and Cotton Rotation System

Abstract Use of novel crops for bio-fuel production requires evaluating the potential for sound ecological and economical implementation in a particular region. We examined the pest and generalist beneficial insect species associated with various winter cover crops (including narrowleaf lupin, white vetch, Austrian winter pea, crimson clover, faba bean, and rye) as sources of colonists in 2 subsequent summer crops, sorghum and cotton. Sorghum is a potential cellulosic bio-fuel crop and cotton is commonly grown in the region and could be a viable low-input rotation for biofuel sorghum. Insects were sampled weekly over 3 ys in winter cover plots beginning in early spring and in the later planted crop plots beginning at the 15 cm height stage of the crops and continuing for 3 - 6 wks. Of the predators, coccinellids (Coleoptera: Coccinellidae) dominated and were consistently abundant in vetch, faba and lupin, as was the pea aphid, Acyrthosiphon pisum Harris (Hemiptera: Aphididae) and the aphid parasitoid, Lysiphlebus testaceipes Cresson (Hymenoptera: Aphiidae). Orius spp. (Hemiptera: Anthocoridae) dominated in lupin. Of the pest species, thrips spp. (Thysanoptera: Thipidae) were highest in lupin and pea, and stink bugs (Hemiptera: Pentatomidae) were highest in clover. No differences in chinch bugs (Hemiptera: Lygaeidae) were found among the covers. There was a ‘relay’ of these species into all of the summer crop plots from living winter crops. Boll damage from stink bugs was highest in the cotton following lupin, pea and fallow with fertilizer; there was no damage from chinch bugs in sorghum. Faba beans had declining stands over the 3 ys, suggesting that this species would not be a reliable winter crop in this system. Vetch and lupin may be the best candidates as banker plants because of their ability to consistently sustain pea aphids and coccinellids, the former which is a nonpest of sorghum and cotton.
The Corpus as Tutor: Data-driven Persuasive Language Learning

This paper presents a new persuasive technology that uses a corpus stored in a database to generate learning objects for tutoring of self-directed learning. The technology was developed within the European Union project EuroPLOT 2010-2013 in order to drive effective learning through technology with, in, and around a corpus application. The paper argues that a corpus can generate learning objects, but a theory of Persuasive Technology must to be applied to optimise the design for learning. The paper presents Bible Online Learner as the implementation of this new architecture for persuasive corpus-driven learning, persuading the learner to focus on the form of the text through the interface and then guiding the learner into practice authentic forms. The corpus used is a database of the Hebrew Bible created by the EepTalstra Centre for Bible and Computer at the VU University in Amsterdam for and called ETCBC4.
Cross-regional Cross-level Encryption Collaborative Data Transmission

In recent years, there has been a sharp increase in the number of collaborative execution cases in China. The enforcement of major difficult cases or some related cases need to be accepted and coordinated in multiple courts. Such cases have a significant affect, the implementation process is often highly concerned by the society. Therefore, it often relies on an integrated and coordinated remote command platform. How to ensure reliable data transmission of the collaborative command platform has become a key technical issue. In the existing public network environment, active attacks or passive attacks and other network attacks make data transmission unreliable. Therefore, in addition to the existing necessary security guarantees, we have presented a hybrid encrypted data transmission method based on elliptic curve cryptography (ECC) and a lightweight stream cipher encryption for the collaborative remote command platform. It provides safe and effective auxiliary support to realize secure communication, remote collaboration and cross-level management for the cross-regional cross-level’s courts.
Android-based Parental Monitoring Apps

Nowadays the usage of handheld devices in a young generation were constantly increasing. Handheld devices had been involved in high profiles cases that involved children, therefore strict monitoring of children’s devices usage are required for safety risks. This project is to develop Stealth-based Android Parental Monitoring App to help parent monitor their child’s mobile activity silently. The mobile usage behavior can be analyze and then parents can plan for proactive measures to deal with the problem. This application was developed based on client server application, where Android based application is developed for client side and web application is developed on the server-side. Authentication process is required to activate the application, as only authenticated user can manage the application and at the same time, the application will run stealthily, invisible from the users. Pattern Lock and password method were used for authentication process. For the purpose of stealth process, “secret door” technique, where developer will disable an application component; this technique will have the effect of removing an application shortcut from any Launcher. The application at android based will be able to log the location, message log, call log, network log, and device information. The collected data will be uploaded to a web server to be reviewed through the internet-enabled devices. The functionality testing were done on both Android Based client side application and web application server side web application. For client side application eight test cases were developed: Android Authentication Module, Android device registration module, Android logging module, Android uploading module, Android system cleaner module, Android stealth hide/reveal icon module, Android stealth launch application via dialer module and Android protection module. For each test case, the result is indicated as pass. For Server Side Web application, four test cases were developed; Web Application Registration Module, Web Application Authentication Module, Web Application Monitoring Module and Web Application Disconnect Device Module. For each test case, the result is indicated as pass. Android Based Parental Monitoring Apps has been successfully developed and meet the development objective to collect Android critical data including network log, call log, device information log, incoming or outgoing SMS and Call logs in stealth and synchronized it to the server where it can be used as digital evidence if necessary. The result of this project is hoped to benefits the society by providing a better monitoring technique for the concerned parent via implementing an alternate way on how to continuously collect and monitor their children/teen mobile activity.
Establishment and application of real-time PCR-based methods to study the epidemiology of Fusarium Head Blight

Fusarium head blight (FHB) is a disease of cereal crops, which has a severe impact on wheat production worldwide. Apart from reducing the yield and impairing grain quality, FHB leads to contamination of grain with mycotoxins. The Fusarium species primarily involved in FHB are F. graminearum and F. culmorum, both producing deoxynivalenol (DON), the most important mycotoxin in wheat grain. Although the relative importance of F. graminearum and F. culmorum and their infection pathways has great impact on epidemiological questions, it has not be clarified in all details so far. For the differentiation of these pathogens, two real-time PCR methods were developed and applied, which allow a qualitative and quantitative detection of fungal biomass within host tissue. Samples for this study have been collected throughout Germany from 2003 to 2005. F. graminearum and F. culmorum were determined qualitatively in symptomatic wheat rachides with a duplex PCR assay enabling the identification of the causal agent of FHB in a single PCR reaction. The method is based on the analysis of melting curves of amplification products generated in a real-time PCR thermocycler. The quantitative detection of both fungi in complex plant material like wheat flour and plant debris was realized in separated real-time PCR reactions, applying SYBR Green I fluorescence detection. The specificity of both assays for F. graminearum and F. culmorum was confirmed. Suitable high-throughput DNA extraction methods were developed for all types of samples analyzed in this study, including wheat rachides, grain samples and plant debris. For quantitative PCR, an upscaled DNA extraction protocol with increased extraction efficiency was used to reduce the sampling error. In addition to the analysis with the quantitative PCR, the DON content of the grain samples was measured. The scope of the study was both the identification of the infecting agent in the wheat rachides and the determination of the relative importance of F. graminearum and F. culmorum in relation to the DON content of wheat samples to establish a risk assessment model for FHB. The results show that F. graminearum is the main causing agent of FHB and DON contamination in Germany. F. culmorum was sometimes detected in wheat rachides of 2003, but did not play a significant role in wheat grain samples 2003 to 2005. The collected data serve to adjust quantitative parameters of a computer-based decision support system aiming at the minimization of Fusarium infection and toxin contamination of grain in Germany, which is being developed by our collaborators.
Low Power 6-Transistor Latch Design for Portable Devices

The latest advances in mobile battery-powered devices such as the Personal Digital Assistant (PDA) and mobile phones have set new goals in digital VLSI design. The portable devices require high speed and low power consumption. Even low power consumption is the dominant requirement and to do so speed can be compromised. In this paper a novel area efficient latch design is proposed. The simulation results show that the proposed design with less transistor count is better choice for low power and high speed portable applications. Keywords: Latch, Low power, Portable, 8T, 6T, Power consumption, Delay.
Sub-Pixel Edge Detection Algorithm Based on Canny-Zernike Moment Method

In order to solve the problems of low efficiency and long running time caused by the traditional Zernike moment method for convolution calculation of the whole image, this paper combines the canny detection algorithm with the Zernike moment method. First, the canny edge detection algorithm, which combined with the Otsu threshold method, is used to extract the pixel edge of the image. Then an improved Hough transform method is used to fit the geometric edge in the image. Based on this, the Zernike moment method is applied to realize sub-pixel positioning of images. The algorithm improves the deficiencies of direct sub-pixel detection, improving accuracy and reducing running time. To verify the effectiveness of the proposed algorithm, the algorithm is applied to the dimension measurement experiment of T-type guide way. The results clearly show that the algorithm is superior to the traditional algorithm in accuracy.
DC Microgrid for Wind and Solar Power Integration

To help the coordination of wind and sun based power inside microgrids. An amassed form of sustainable breeze and sun quality age estimate is proposed to help the measurement of the operational save for day ahead of time and ongoing booking. At that point, a stoop control for power advanced converters identified with battery stockpiling is created and inspected. that is appeared to hold the balance of the microgrid's genuine time supply and call for. earlier undiscovered breeze and sun power are gathered on the rooftop and sides of a pinnacle, in this way supporting conveyance to electric autos on the floor. [19],[20],[21]
Differences in Cerebral Angioarchitectonics in Alzheimer's Disease in Comparison with Other Neurodegenerative and Ischemic Lesions

Introduction: The research focuses on the clinical study of cerebral angioarchitectonics and microcirculation disorders in the development of Alzheimer’s disease (AD) in comparison with other neurodegenerative and ischemic lesions. Materials and methods: 1117 patients with different types and stages of neurodegenerative and ischemic lesions were examined, 93 of whom (8.33%) had different stages of AD—Test Group; 1024 (91.67%) had cerebral atherosclerosis, Binswanger disease (BD), vascular Parkinsonism (VP)—Control Group. The examination included definition of CDR, MMSE, cerebral CT, MRI, cerebral sciagraphy (SG), rheoencephalography (REG), morphometric detection of AD stages with TDR, and cerebral multi-gated angiography (MUGA). Results: In all patients with AD, regardless of the disease stage, specific сerebral small vessel disease (CSVD), manifested by dyscirculatory angiopathy of Alzheimer’s type (DAAT), was detected in the temporal and fronto-parietal areas. Conclusions: DAAT is an AD-specific lesion of cerebral microvessels that changes hemodynamics, causes cerebral hypoxia, and contributes to impaired amyloid beta metabolism. The combination of deposition of amyloid beta in the cerebral tissue and vascular wall, as well as specific disorders of microcirculation, cause neurodegeneration and AD development. Patients with other neurodegenerative and ischemic lesions had no DAAT manifestations.
Code list management supported through a controlled domain vocabulary

Standards like the ISO 19152:2012 Land Administration Domain Model (LADM) basically specifies classes and the relations among them. However, this methodology cannot catch the richness of variations of the domain, and therefore code lists are introduced as a supplement. In fact, the LADM mentions a number of code lists for each of the packages of the standard. The codes with name and description are not part of the standard; rather, examples are provided in an informative Annex J of the standard, while the specification of the code lists is left to ‘User communities [who] have to define and manage their own values when implementing this International [LADM] Standard’. As the mentioned user communities all belong to the domain of Land Administration, the specification of code lists would benefit from applying a shared or harmonized terminology. The alternative would lead to communication problems and costs. Within other domains, e.g. agriculture, economy, and environment, controlled vocabularies have been developed (AGROVOC; STW–Thesaurus for Economics; GEMET), each amounting to several thousand terms. The Cadastre and Land Administration Thesaurus (CaLAThe) was issued 2011, based on the then draft version of LADM. The present CaLAThe version 3 of 2019 was extended to about 200 terms, reflecting also the terms of the OGC Land and Infrastructure Conceptual Model Standard (LandInfra) of 2016. The paper explores the potential of applying CaLAThe for code list management, motivated among others by the decision by ISO/TC 211 to revise LADM in terms of a Stage 0-project. Semantic web tools are investigated in order to provide for more explicit semantics of code list values (cf. van Oosterom et al., 2019), in line with previous proposals (Paasch et al., 2015) and (Stubkjaer et al., 2018). Moreover, suggestions for international cooperation are outlined.
Attitude Control of Satellite with PWPF Modulator using Predictive Control Algorithms

In this paper, we use generalized incremental predictive control to stabilize attitude of satellite. We compare GPC with GIPC algorithm and present that GIPC has better performance. The three-axis attitude control systems are activated in pulse mode. Consequently, a modulation of the torque command is compelling in order to avoid high non-linear control action. This work considers the Pulse-Width Pulse-Frequency modulator is composed of a Schmitt trigger, a first order filter, and a feedback loop. PWPF modulator has several advantages over classical bang-bang controllers such as close to linear operation, high accuracy, and reduced propellant consumption. 与PWPF调制器卫星姿态控制中使用预测控制算法伊赫桑抽象在本文中，我们用广义增量预测控制，以稳定卫星姿态。 我们比较GPC与GIPC算法，并提交GIPC具有更好的性能。 三轴姿态控制系统在脉冲模式激活。 因此，转矩指令的调制是为了避免高非线性控制动作引人注目。 这个工作考虑了脉冲宽度脉冲频率调制器是由一个施密特触发器，一个一阶滤波器，以及一个反馈环路。 PWPF调制器拥有经典砰 - 砰控制器的优点很多，比如接近线性操作，精度高，并减少推进剂消耗。