Miracle-dz/UniFAR-FTUs huggingface dataset:
Modelling the Influence of Electromagnetic Field on the User of a Wearable IoT Device Used in a WSN for Monitoring and Reducing Hazards in the Work Environment

The aim of this study was to evaluate the absorption in a user’s head of an electromagnetic field (EMF) emitted by the Wi-Fi and/or Bluetooth module of a wearable small Internet of Things (IoT) electronic device (emitting EMF of up to 100 mW), in order to test the hypothesis that EMF has an insignificant influence on humans, and to compare the levels of such EMF absorption in various scenarios when using this device. The modelled EMF source was a meandered inverted-F antenna (MIFA)-type antenna of the ESP32-WROOM-32 radio module used in wearable devices developed within the reported study. To quantify the EMF absorption, the specific energy absorption rate (SAR) values were calculated in a multi-layer ellipsoidal model of the human head (involving skin, fat, skull bones and brain layers). The obtained results show up to 10 times higher values of SAR from the MIFA located in the headband, in comparison to its location on the helmet. Only wearable IoT devices (similar in construction and way of use to the investigated device) emitting at below 3 mW equivalent isotropically radiated power (EIRP) from Wi-Fi/Bluetooth communications modules may be considered environmentally insignificant EMF sources.
A Rational Insight into the Effect of Dimethyl Sulfoxide on TNF-α Activity

Direct inhibition of tumor necrosis factor-alpha (TNF-α) action is considered a promising way to prevent or treat TNF-α-associated diseases. The trimeric form of TNF-α binds to its receptor (TNFR) and activates the downstream signaling pathway. The interaction of TNF-α with molecular-grade dimethyl sulfoxide (DMSO) in an equal volumetric ratio renders TNF-α inert, in this state, TNF-α fails to activate TNFR. Here, we aimed to examine the inhibition of TNF-α function by various concentrations of DMSO. Its higher concentration led to stronger attenuation of TNF-α-induced cytokine secretion by fibroblasts, and of their death. We found that this inhibition was mediated by a perturbation in the formation of the functional TNF-α trimer. Molecular dynamics simulations revealed a transient interaction between DMSO molecules and the central hydrophobic cavity of the TNF-α homodimer, indicating that a brief interaction of DMSO with the TNF-α homodimer may disrupt the formation of the functional homotrimer. We also found that the sensitizing effect of actinomycin D on TNF-α-induced cell death depends upon the timing of these treatments and on the cell type. This study will help to select an appropriate concentration of DMSO as a working solvent for the screening of water-insoluble TNF-α inhibitors.
Clinical characteristics and outcomes of adults with peripheral extracorporeal membrane oxygenation in a developing country: A single center 8-year retrospective study

Introduction: In our institute, we began using peripheral veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) in 2010, and peripheral veno-venous (VV) ECMO in 2015. This study aimed to describe clinical characteristics and outcomes in those patients. Methods: We reviewed retrospective data of adults receiving peripheral ECMO from January 2010 to December 2017 and divided it into two groups for analysis: VA- and VV-ECMO. Results: There were 28 patients in the VA group and 12 in VV. For VA, the mean (SD) age was 58.5 (17.2) years. The most common indication was cardiac arrest (12 patients, 42.9%); 15 patients (53.6%) were on intra-aortic balloon pump concomitantly. In the VV cohort, the mean age was 53.3 (16.2) years. Eleven (91.7%) patients had acute respiratory distress syndrome as an indication. The mortality rate of VA-ECMO was 85.7%, and VV was 58.3%. Conclusion: The mortality rate in our ECMO center was considerably higher than that in the international registry report. Improved team education, rigid patient selection criteria, and a reimbursement protocol should lead to ameliorated outcomes. Trial Registration: TCTR20190120001. Registered January 19, 2019
Ancient microRNA profiles of 14,300-yr-old canid samples confirm taxonomic origin and provide glimpses into tissue-specific gene regulation from the Pleistocene

DNA sequencing is the current key technology for historic or ancient biological samples and has led to many exciting discoveries in the field of paleogenomics. However, functional insights into tissue identity, cellular composition, or gene regulation cannot be gained from DNA. Recent analyses have shown that, under favorable conditions, RNA can also be sequenced from ancient samples, enabling studies at the transcriptomic and regulatory level. Analyzing ancient RNA data from a Pleistocene canid, we find hundreds of intact microRNAs that are taxonomically informative, show tissue specificity and have functionally predictive characteristics. With an extraordinary age of 14,300 yr, these microRNA sequences are by far the oldest ever reported. The authenticity of the sequences is further supported by (i) the presence of canid/Caniformia-specific sequences that never evolved outside of this clade, (ii) tissue-specific expression patterns (cartilage, liver, and muscle) that resemble those of modern dogs, and (iii) RNA damage patterns that are clearly distinct from those of fresh samples. By performing computational microRNA-target enrichment analyses on the ancient sequences, we predict microRNA functions consistent with their tissue pattern of expression. For instance, we find a liver-specific microRNA that regulates carbohydrate metabolism and starvation responses in canids. In summary, we show that straightforward paleotranscriptomic microRNA analyses can give functional glimpses into tissue identity, cellular composition, and gene regulatory activity of ancient samples and biological processes that took place in the Pleistocene, thus holding great promise for deeper insights into gene regulation in extinct animals based on ancient RNA sequencing.
Predicting the clinically significant subscapularis tendon tear: malposition and tear of the long head of the biceps tendon on shoulder magnetic resonance imaging

Background The diagnostic accuracy of magnetic resonance imaging (MRI) is low for detecting a subscapularis tendon tear. Purpose To identify MRI findings that may predict the presence of a clinically significant subscapularis tendon tear requiring surgical repair. Material and Methods We reviewed shoulder MR images of patients who had undergone arthroscopic rotator cuff repair at our institution between June 2018 and May 2019. Patients were divided into two groups: the study group (n = 51), with an intermediate- to high-grade partial thickness tear of the subscapularis tendon suspected on preoperative MRI and intermediate or higher grade of the tendon tear proven on arthroscopy; and the control group (n = 18), with an intermediate- to high-grade partial thickness tear of the subscapularis tendon suspected on preoperative MRI but no tear or low-grade partial thickness tear of the tendon shown on arthroscopy. Preoperative MR images were retrospectively evaluated by two readers for the size of the subscapularis tendon tear, bone reactions at the lesser tuberosity, and long head of the biceps tendon (LHBT) pathology. Results The subscapularis tendon tear measured by reader 2 was larger in the study group than in the control group. The prevalence of a tear (P = 0.006 for reader 1; P = 0.011 for reader 2) and malposition (P < 0.001 for both readers) of the LHBT were significantly greater in the study group. Conclusion A tear and malposition of the LHBT on MR images may predict the presence of a clinically significant subscapularis tendon tear.
Emerging roles of SIRT6 in human diseases and its modulators

The biological functions of sirtuin 6 (SIRT6; e.g., deacetylation, defatty‐acylation, and mono‐ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental processes controlling aging such as DNA repair, gene expression, and telomeric maintenance. Over the past decades, the aberration of SIRT6 has been extensively observed in diverse life‐threatening human diseases. In this comprehensive review, we summarize the critical roles of SIRT6 in the onset and progression of human diseases including cancer, inflammation, diabetes, steatohepatitis, arthritis, cardiovascular diseases, neurodegenerative diseases, viral infections, renal and corneal injuries, as well as the elucidation of the related signaling pathways. Moreover, we discuss the advances in the development of small molecule SIRT6 modulators including activators and inhibitors as well as their pharmacological profiles toward potential therapeutics for SIRT6‐mediated diseases.
Satellitosis, a Crosstalk between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour

Simple Summary This article reviews the concept of cellular satellitosis as originally described histologically by Santiago Ramón y Cajal in 1899 and Hans Joachim Scherer, more specifically in the context of glioblastoma invasiveness, during the early part of the 20th century. With the advent of new and emerging molecular technologies in the 21st century, the significance of both vascular and neuronal satellitosis by neoplastic cells offers intriguing possibilities into further clarifying the development, pathobiology and therapy of malignant glioma through closer investigation into the nature of these histological hallmarks. Abstract The secondary structures of Scherer commonly known as perineuronal and perivascular satellitosis have been identified as a histopathological hallmark of diffuse, invasive, high-grade gliomas. They are recognised as perineuronal satellitosis when clusters of neoplastic glial cells surround neurons cell bodies and perivascular satellitosis when such tumour cells surround blood vessels infiltrating Virchow–Robin spaces. In this review, we provide an overview of emerging knowledge regarding how interactions between neurons and glioma cells can modulate tumour evolution and how neurons play a key role in glioma growth and progression, as well as the role of perivascular satellitosis into mechanisms of glioma cells spread. At the same time, we review the current knowledge about the role of perineuronal satellitosis and perivascular satellitosis within the tumour microenvironment (TME), in order to highlight critical knowledge gaps in research space.
Personal practice in counselling and CBT trainees: the self-perceived impact of personal therapy and self-practice/self-reflection on personal and professional development

ABSTRACT With growing evidence for the potential value of personal practices (PPs) in therapist training, it is important to determine which PPs may be most valuable for which therapists under what conditions. This is the first study to compare the impact of two different PPs selected by accredited therapy training programs as the most appropriate PP for their trainees. Using the same validated outcome measure, the Self-focused Practice Questionnaire, the impact of personal therapy for counselling psychology trainees was compared with the impact of self-practice/self-reflection (SP/SR) training for CBT trainees. The number of PP hours was similar across the two groups. The SP/SR group were older and may have been more experienced professionally. SP/SR was perceived by CBT trainees to be significantly more beneficial for personal and professional development than personal therapy by counselling trainees. Possible reasons are discussed. Although the study does not constitute a direct experimental comparison of personal therapy and SP/SR amongst matched trainees of the same theoretical orientation, it is notable in demonstrating that in training contexts where PP was mandatory, SP/SR was experienced more positively by the CBT trainees than personal therapy by the counselling trainees.
Improved GNSS-Based Bistatic SAR Using Multi-Satellites Fusion: Analysis and Experimental Demonstration

The Global Navigation Satellite System (GNSS)-based Bistatic Synthetic Aperture Radar (SAR) is getting more and more attention in remote sensing for its all-weather and real-time global observation capability. Its low range resolution results from the narrow signal bandwidth limits in its development. The configuration difference caused by the illumination angle and movement direction of the different satellites makes it possible to improve resolution by multi-satellite fusion. However, this also introduces new problems with the resolution-enhancing efficiency and increased computation brought about by the fusion. In this paper, we aim at effectively improving the resolution of the multi-satellite fusion system. To this purpose, firstly, the Point Spread Function (PSF) of the multi-satellite fusion system is analyzed, and focusing on the relationship between the fusion resolution and the geometric configuration and the number of satellites. Numerical simulation results show that, compared with multi-satellite fusion, dual-satellite fusion is a combination with higher resolution enhancement efficiency. Secondly, a method for dual-satellite fusion imaging based on optimized satellite selection is proposed. With the greedy algorithm, the selection is divided into two steps: in the first step, according to geometry configuration, the single-satellite with the optimal 2-D resolution is selected as the reference satellite; in the second step, the angles between the azimuthal vector of the reference satellite and the azimuthal vector of the other satellites were calculated by the traversal method, the satellite corresponding to the intersection angle which is closest to 90° is selected as the auxiliary satellite. The fused image was obtained by non-coherent addition of the images generated by the reference satellite and the auxiliary satellite, respectively. Finally, the GPS L1 real orbit multi-target simulation and experimental validation were conducted, respectively. The simulation results show that the 2-D resolution of the images produced by our proposed method is globally optimal 15 times and suboptimal 8 times out of 24 data sets. The experimental results show that the 2-D resolution of our proposed method is optimal in the scene, and the area of the resolution unit is reduced by 70.1% compared to the single-satellite’s images. In the experiment, there are three navigation satellites for imaging, the time taken to the proposed method was 66.6% that of the traversal method. Simulations and experiments fully demonstrate the feasibility of the method.
Dataset Construction from Naturalistic Driving in Roundabouts

A proper driver characterization in complex environments using computational techniques depends on the richness and variety of data obtained from naturalistic driving. The present article proposes the construction of a dataset from naturalistic driving specific to maneuvers in roundabouts and makes it open and available to the scientific community for performing their own studies. The dataset is a combination of data gathered from on-board instrumentation and data obtained from the post-processing of maps as well as recorded videos. The approach proposed in this paper consists of handling roundabouts as a stretch of road that includes 100 m before the entrance, the internal part, and 100 m after the exit. This stretch of road is then spatially sampled in small sections to which data are associated.
The use of conversational agents in rehabilitation following brain injury, disease, or stroke: a scoping review protocol.

BACKGROUND Rehabilitation for adults with brain injury or disease or stroke provides goal-directed care to overcome functional impairments and reduced independence. However, recovery can be impacted due to rehabilitation being time limited. New therapy approaches supporting rehabilitation and self-management are warranted. Conversational agents provide personal computer-based dialogues that can be designed to meet the specific needs of clients. Interacting with a conversational agent may support rehabilitation for clients with brain injury, disease or stroke. OBJECTIVE The objective of the review is to identify peer-reviewed literature reporting the design and use of conversational agents in rehabilitation for adults with brain injury, disease, or stroke. INCLUSION CRITERIA Studies, written in English, that report the design and/or use of conversational agents in rehabilitation for adults aged over 18 years with brain injury, disease, or stroke will be considered for inclusion. Research settings may include hospitals, community settings, and homes. Eligible study types are peer-reviewed research protocols, prototype development papers, and pilot and clinical trials. METHODS Primary sourcing databases (MEDLINE [Ovid], Scopus, ProQuest, Web of Science) and gray literature sources will be searched with no data range limitations. Only studies published in English will be considered due to feasibility limitations. The JBI System for the Unified Management, Assessment and Review of Information (JBI SUMARI) will be used. Two independent reviewers will screen the retrieved papers by title and abstract, and the selected papers by full-text review. Any disagreements will be resolved by an objective arbitrator. Data to be extracted and analyzed from included papers will include details of participants, concept, context, and the study design. Results will be presented narratively and in tabular format.
A Facile Synthesis of Some 3-(2-Pyridyl)coumarins.

Various 3-pyridyland 4-pyridyl-coumarins are reported to possess diverse biological activities'-4 such as CNS depressant, fish toxicity and antifungal. In literature these compounds have been prepared by Pechmann or Perkin reaction and require either pyridoyl acetic acid/ester or pyridine acetic acid/ester as a condensing reagent. Although these methods are simple they do not provide substitution in pyridine part. Hence with a view to developing new methods which can provide substitution in pyridine part, earlier we had reported synthesis of some 3-(2pyridyl)coumarins in which the compounds were prepared by reacting 3-coumarinoyl methyl pyridium bromide with a , ~unsaturated ketones (chalcones) in the presence of ammonium acetate in acetic acid utilizing Kroehnke 's reaction. Now in the present work we report the synthesis of such 3-(2pyridyl)coumarins by interchanging the functionality of the reacting components. Thus various coumarin chalcones 3a-f have been reacted ~ith aroyl methyl pyridinium bromides 4a-d in the presence of ammonium acetate in acetic acid to gIve 3-(2pyridyl)coumarins 5a-x (Scheme I). The required coumarin chalcones 3a-f were prepared by the condensation of 3-acetylcoumarins la-c with aromatic aldehydes 2a-b in the presence of piperidine in ethanol. The coumarin chalcones 3a-f were then reacted with aroyl methyl pyridinium bromides 4a-d in the presence of ammonium acetate in acetic acid to afford 3-(2-pyridyl)coumarins 5a-x in + ®x, R, k-b la~ a : R,"'R,=H b : R, = Br, R. , = H a: R,=CH., R, = H
Regulation of Oncogenic Targets by the Tumor-Suppressive miR-139 Duplex (miR-139-5p and miR-139-3p) in Renal Cell Carcinoma

We previously found that both the guide and passenger strands of the miR-139 duplex (miR-139-5p and miR-139-3p, respectively) were downregulated in cancer tissues. Analysis of TCGA datasets revealed that low expression of miR-139-5p (p < 0.0001) and miR-139-3p (p < 0.0001) was closely associated with 5-year survival rates of patients with renal cell carcinoma (RCC). Ectopic expression assays showed that miR-139-5p and miR-139-3p acted as tumor-suppressive miRNAs in RCC cells. Here, 19 and 22 genes were identified as putative targets of miR-139-5p and miR-139-3p in RCC cells, respectively. Among these genes, high expression of PLXDC1, TET3, PXN, ARHGEF19, ELK1, DCBLD1, IKBKB, and CSF1 significantly predicted shorter survival in RCC patients according to TCGA analyses (p < 0.05). Importantly, the expression levels of four of these genes, PXN, ARHGEF19, ELK1, and IKBKB, were independent prognostic factors for patient survival (p < 0.05). We focused on PXN (paxillin) and investigated its potential oncogenic role in RCC cells. PXN knockdown significantly inhibited cancer cell migration and invasion, possibly by regulating epithelial–mesenchymal transition. Involvement of the miR-139-3p passenger strand in RCC molecular pathogenesis is a new concept. Analyses of tumor-suppressive-miRNA-mediated molecular networks provide important insights into the molecular pathogenesis of RCC.
Poor Sleep Quality Experience and Self-Management Strategies in Fibromyalgia: A Qualitative Metasynthesis

Poor sleep quality is a major concern and a highly prevalent symptom in fibromyalgia. We aimed to develop a metasynthesis of qualitative studies to assess how people diagnosed with fibromyalgia experience and manage poor sleep quality following the concepts of the Symptom Management Theory. The principles of metasynthesis established by Sandelowski and Barroso were utilized. A pre-planned comprehensive search was implemented in PubMed, Scopus, ISI WebofScience, and Cinahl Plus databases. The methodological quality was assessed following the CASP Qualitative Checklist. The findings of the studies were subjected to a metasummary and a metasynthesis. Seventeen studies were included in the metasynthesis. Two overarching themes were pre-established: (1) experience of poor sleep quality in Fibromyalgia and (2) poor sleep quality management strategies in Fibromyalgia. Four sub-themes emerged from the results: (1) evaluation of poor sleep quality, (2) response to poor sleep quality, (3) management strategies to favor sleep, and (4) managing the consequences of a sleepless night. Poor sleep quality is a severe and disabling symptom that negatively impacts the general health status of people diagnosed with FM. Prescribed treatments are commonly seen as ineffective and self-management strategies are a last resort and do not show beneficial effects.
Forager age and foraging state, but not cumulative foraging activity, affect biogenic amine receptor gene expression in the honeybee mushroom bodies

Foraging behavior is crucial for the development of a honeybee colony. Biogenic amines are key mediators of learning and the transition from in‐hive tasks to foraging. Foragers vary considerably in their behavior, but whether and how this behavioral diversity depends on biogenic amines is not yet well understood. For example, forager age, cumulative foraging activity or foraging state may all be linked to biogenic amine signaling. Furthermore, expression levels may fluctuate depending on daytime. We tested if these intrinsic and extrinsic factors are linked to biogenic amine signaling by quantifying the expression of octopamine, dopamine and tyramine receptor genes in the mushroom bodies, important tissues for learning and memory. We found that older foragers had a significantly higher expression of Amdop1, Amdop2, AmoctαR1, and AmoctβR1 compared to younger foragers, whereas Amtar1 showed the opposite pattern. Surprisingly, our measures of cumulative foraging activity were not related to the expression of the same receptor genes in the mushroom bodies. Furthermore, we trained foragers to collect sucrose solution at a specific time of day and tested if the foraging state of time‐trained foragers affected receptor gene expression. Bees engaged in foraging had a higher expression of Amdop1 and AmoctβR3/4 than inactive foragers. Finally, the expression of Amdop1, Amdop3, AmoctαR1, and Amtar1 also varied with daytime. Our results show that receptor gene expression in forager mushroom bodies is complex and depends on both intrinsic and extrinsic factors.