Miracle-dz/UniFAR-FTUs huggingface dataset:
Pregnancy in vasculitis

Little is known about pregnancy in patients with vasculitis because of the nature of these diseases and the potential for infertility to occur from effective treatments. However, with the expanding armamentarium of therapeutic options that do not affect reproductive function, it is anticipated that more vasculitis patients will entertain the possibility of conception and consider the outcomes of pregnancy. Relevant issues include the effects of the vasculitis on pregnancy, the effects of the pregnancy on vasculitic disease activity, and the impact of medications used during the peripartum period. Although available data are limited and fall short in many regards, there is support for successful outcomes of pregnancy when conception occurs in disease remission. Maternal and fetal outcome is optimized by the establishment of a multidisciplinary team that can provide preconception evaluation and counseling followed by frequent monitoring throughout the pregnancy and the postpartum period.
Analyser et représenter la progression de la difficulté d’un jeu sérieux du point de vue ludique et pédagogique

Avec le developpement de l’apprentissage mobile, des jeux serieux suivent cette tendance en proposant des jeux concus autour d’un ensemble de nombreux niveaux dedies a la pratique des competences specifiques. Ils ont la particularite de presenter des niveaux courts sous forme de casse-tetes adaptes aux situations mobiles. Comme dans les jeux video, il est tres important d’offrir un defi progressif ou encore mieux un defi adapte pour l’apprenant. La conception de niveaux est la plupart du temps empirique : certains sont evalues trop faciles, d’autres trop difficiles, ou encore mal places dans la progression generale et certains ajustements sont faits progressivement. Dans cet article, nous nous concentrons donc sur une methodologie pour decrire les niveaux d’un jeu d’apprentissage tant du point de vue ludique que du point de vue pedagogique afin d’etre en mesure d’evaluer la progression (difficulte, apprentissage, challenge/plaisir). Nous avons applique cette approche a des jeux d’apprentissage et avons ete en mesure de suggerer des ameliorations ou plus simplement d’en representer une vision globale, qui est une condition sine qua non pour une adaptation plus fine du defi offert a chaque apprenant.
Molecular Remodeling of Left and Right Ventricular Myocardium in Chronic Anthracycline Cardiotoxicity and Post-Treatment Follow Up

Chronic anthracycline cardiotoxicity is a serious clinical issue with well characterized functional and histopathological hallmarks. However, molecular determinants of the toxic damage and associated myocardial remodeling remain to be established. Furthermore, details on the different propensity of the left and right ventricle (LV and RV, respectively) to the cardiotoxicity development are unknown. Hence, the aim of the investigation was to study molecular changes associated with remodeling of the LV and RV in chronic anthracycline cardiotoxicity and post-treatment follow up. The cardiotoxicity was induced in rabbits with daunorubicin (3 mg/kg/week for 10 weeks) and animals were sacrificed either at the end of the treatment or after an additional 10 weeks. Daunorubicin induced severe and irreversible cardiotoxicity associated with LV dysfunction and typical morphological alterations, whereas the myocardium of the RV showed only mild changes. Both ventricles also showed different expression of ANP after daunorubicin treatment. Daunorubicin impaired the expression of several sarcomeric proteins in the LV, which was not the case of the RV. In particular, a significant drop was found in titin and thick filament proteins at both mRNA and protein level and this might be connected with persistent LV down-regulation of GATA-4. In addition, the LV was more affected by treatment-induced perturbations in calcium handling proteins. LV cardiomyocytes showed marked up-regulation of desmin after the treatment and vimentin was mainly induced in LV fibroblasts, whereas only weaker changes were observed in the RV. Remodeling of extracellular matrix was almost exclusively found in the LV with particular induction of collagen I and IV. Hence, the present study describes profound molecular remodeling of myocytes, non-myocyte cells and extracellular matrix in response to chronic anthracycline treatment with marked asymmetry between LV and RV.
Redox Homeostasis in Cardiovascular Disease: The Role of Mitochondrial Sirtuins

Cardiovascular disease (CVD) is still the leading cause of death worldwide. Despite successful advances in both pharmacological and lifestyle strategies to fight well-established risk factors, the burden of CVD is still increasing. Therefore, it is necessary to further deepen our knowledge of the pathogenesis of the disease for developing novel therapies to limit even more its related morbidity and mortality. Oxidative stress has been identified as a common trait of several manifestations of CVD and could be a promising target for innovative treatments. Mitochondria are a major source of oxidative stress and sirtuins are a family of enzymes that generate different post-translational protein modifications, thus regulating important cellular processes, including cell cycle, autophagy, gene expression, and others. In particular, three sirtuins, SIRT3, SIRT4, and SIRT5 are located within the mitochondrial matrix where they regulate energy production and antioxidant pathways. Therefore, these sirtuins are strongly involved in the balance between oxidant and antioxidant mechanisms. In this review, we summarize the activities of these sirtuins with a special focus on their role in the control of oxidative stress, in relation to energy metabolism, atherosclerosis, and CVD.
Suboptimal physician adherence to quality indicators for the management of gout and asymptomatic hyperuricaemia: results from the UK General Practice Research Database (GPRD).

OBJECTIVES : To examine adherence to validated quality indicators assessing the quality of allopurinol use in the treatment of gout and asymptomatic hyperuricaemia. METHODS We determined physician adherence in the UK General Practice Research Database (GPRD) to three validated quality indicators developed to assess the quality of allopurinol prescribing practices. These indicators were developed to assess: (i) dosing in renal impairment; (ii) concomitant use with azathioprine or 6-mercaptopurine; and (iii) use in the treatment of asymptomatic hyperuricaemia. We also examined the association of patient-level factors (sociodemographics, comorbidity, follow-up duration and concomitant medicine use) with the treatment of asymptomatic hyperuricaemia using multivariable logistic regression. RESULTS Of the 63 105 gout patients, 185 (0.3%) were eligible for Quality Indicator 1 and 52 (0.1%) were eligible for Quality Indicator 2. There were an additional 471 patients with asymptomatic hyperuricaemia eligible for Quality Indicator 3. Rates of practice deviation for the three individual quality indicators ranged from 25 to 57%. Male sex, older age, a history of chronic renal failure, and a greater number of concomitant medications were significantly associated with increased odds of inappropriate treatment for asymptomatic hyperuricaemia. Hypertension and diuretic use were associated with lower odds of this practice. CONCLUSIONS One-quarter to one-half of all patients eligible for at least one of the validated quality of care indicators were subject to possible allopurinol prescribing error, suggesting that inappropriate prescribing practices are widespread with this agent. Future interventions aimed at reducing inappropriate allopurinol use are needed and should be targeted towards high-risk groups, including older men and those receiving multiple concomitant medications.
Expressando ideias: incrementalidade e tomada de perspectiva na produção da linguagem

A Producao da Linguagem tem sido caracterizada como um processo complexo, resultado de diferentes etapas. O que ocorre nos niveis da producao linguistica e o quao incremental e a transferencia de informacao entre eles sao algumas das questoes estudadas pela Psicolinguistica, dada sua relevância para a compreensao da arquitetura da mente humana. O presente artigo, portanto, investiga a passagem do fluxo informacional do nivel de conceptualizacao de uma ideia para o nivel de codificacao gramatical da mesma, concentrando-se (i) no teor de incrementalidade presente nesta passagem, (ii) na possivel interferencia da tomada de perspectiva sob a qual a ideia sera expressa (se a partir do agente ou do paciente da acao), (iii) na escolha da estrutura sintatica (se voz ativa ou passiva) e, finalmente, (iv) no custo processual implicado nessas decisoes. Alguns desses processos foram acessados atraves de tarefas experimentais de observacao e descricao de cenas, sob a utilizacao da tecnica do rastreamento ocular e de recursos de manipulacao atencional. Os resultados apontam para uma abordagem holistica na passagem de informacao do nivel de conceptualizacao da mensagem para o de codificacao gramatical e sinalizam que operacoes no nivel lexical podem implicar, do ponto de vista processual, menor custo do que a codificacao de uma ideia em uma sentenca na voz passiva. Alem disso, os dados indicam que a tomada de perspectiva possa ser uma subetapa do processo de conceptualizacao da mensagem, com impactos para a codificacao gramatical
An Industrial Evaluation of Unit Test Generation: Finding Real Faults in a Financial Application

Automated unit test generation has been extensively studied in the literature in recent years. Previous studies on open source systems have shown that test generation tools are quite effective at detecting faults, but how effective and applicable are they in an industrial application? In this paper, we investigate this question using a life insurance and pension products calculator engine owned by SEB Life & Pension Holding AB Riga Branch. To study fault-finding effectiveness, we extracted 25 real faults from the version history of this software project, and applied two up-to-date unit test generation tools for Java, EVOSUITE and RANDOOP, which implement search-based and feedback-directed random test generation, respectively. Automatically generated test suites detected up to 56.40% (EVOSUITE) and 38.00% (RANDOOP) of these faults. The analysis of our results demonstrates challenges that need to be addressed in order to improve fault detection in test generation tools. In particular, classification of the undetected faults shows that 97.62% of them depend on either "specific primitive values" (50.00%) or the construction of "complex state configuration of objects" (47.62%). To study applicability, we surveyed the developers of the application under test on their experience and opinions about the test generation tools and the generated test cases. This leads to insights on requirements for academic prototypes for successful technology transfer from academic research to industrial practice, such as a need to integrate with popular build tools, and to improve the readability of the generated tests.
BASES SOCIOTÉCNICAS DE UMA TECNOLOGIA SOCIAL: O TRANSLADAR DA PEDAGOGIA DA ALTERNÂNCIA EM RONDÔNIA

1024x768 O trabalho tem como objetivo discutir sobre o que leva as tecnologias sociais a fracassarem se, diferentemente dos tradicionais desenvolvedores de Pesquisa e Desenvolvimento, os principais envolvidos com essas tecnologias sao os movimentos sociais, cooperativas populares, o rganizacoes n ao g overnamentais, unidades publicas de p esquisa e d esenvolvimento, divisoes governamentais, organismos descentralizados e empresas publicas? Para isso, foi analisada a Pedagogia da Alternância (PA), uma tecnologia social relevante no estado de Rondonia. Metodologicamente, por meio de um estudo de caso, foi realizada uma observacao participante e entrevistas. A analise dos dados foi feita por meio das translacoes como e discutido na Teoria do Ator-Rede. O estudo mostrou que nao e possivel falar em sucesso ou fracasso na expansao da PA em Rondonia, a participacao de diferentes atores, com objetivos e interesses variados e tecnicas e recursos diversos, fez com que em cada localidade a PA fosse especifica e com caracteristicas proprias, nao podendo ser generalizada como algo unico para todo o Estado . Normal 0 21 false false false PT-BR X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:. 0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}
KA BAND SATELLITE CoMMuNICATIoNS DESIgN ANALySIS AND oPTIMISATIoN

Ka band satellite communications (SATCoM) frequencies provide new opportunities to meet high bandwidth demands, especially for small aerial, maritime and mobile land platforms supporting beyond line of sight requirements for networkcentric operations. This is possible due to the availability of 3.5gHz of bandwidth, and also because Ka ground segment components are typically smaller in dimension compared to those of Ku band. However, Ka band links experience much higher rain fades in tropical regions as compared to Ku band and C band. In this article, various factors in the link budget are explored to determine their impact on overall signal strength. These factors can be traded off and optimised to enable the realisation of a Ka band solution for SATCoM.
Harmonizing Improvement Technologies: A Comparison between CMMI-ACQ and ISO/IEC 12207: 2008

Currently a great number of organizations are acquiring products and services from suppliers and developing less and less of these products in-house. The CMMI-ACQ and the ISO/IEC 12207:2008 are process reference model that addressing issue related to software acquisition. With the aim of to offer information on how the practices described in these two models are related, and considering that the comparison is one specific strategy for the harmonization of models, we have carried out a comparison of these two reference models. We have taken into account the latest versions of the models. Furthermore, to carry out this comparison in a way systematic, we defined a process for this purpose. This work intends to support organizations which are interested in introducing or improving their practices for acquisition of products and services using these models.
Glacier Flow in a Curving Channel

Abstract The flow of a glacier along a channel of constant longitudinal curvature is analyzed using analytical and finite-element methods. Channels of various cross–sectional shape are investigated, ranging from a simple rectangular form with zero shear traction along the bed to realistic profiles taken from Blue Glacier, Washington. Terms in the equilibrium and rate-of-deformation equations which are inversely dependent on radius and a body force which varies transversely across the glacier introduce several characteristic features into the stress and velocity fields of the curving glacier. The stress center line is shifted toward the inside of the bend, causing an asymmetric crevasse pattern and non‒zero stress magnitude at the surface on the geometric center line of the channel. The stress field is dependent on the stress exponent in the flow law and is non-linear across the surface. The surface–velocity pattern shows a “tilting” of the usual high‒order parabolic form, being skewed toward the inside of the bend. There is a shift in the velocity maximum from the deepest part of the channel. All of these curvature‒induced features are dependent on the radius of curvature, actual channel geometry, and stress exponent in the flow law. Model results show excellent agreement with the velocity and crevasse patterns on the curving Blue Glacier.
1.5-$\mu{\rm m}$ 10-Gb/s VCSEL Link for Optical Access Applications

We experimentally demonstrate the power budget improvement of a 10-Gb/s vertical-cavity surface-emitting laser (VCSEL) link by utilizing continuous-phase frequency-shift keying (CPFSK)/amplitude-shift keying (ASK) modulation format. We first measure the frequency modulation (FM) response of the VCSEL from 10 kHz to 10 GHz and then exploit dc-balanced line coding to utilize the flat region of the FM response. The CPFSK/ASK signals are generated by directly modulating the VCSEL and utilizing a delay interferometer (DI) for FSK-to-ASK conversion. We successfully transmit the signals over a 50-km dispersion-uncompensated link by optimizing the free-spectral range of the DI. Using the proposed scheme, we achieve > 5-dB improvement in the power budget compared with a conventional VCSEL link.
Clinical value of serum trophoblast cell surface protein 2 (TROP2) antibody in non-small-cell lung cancer patients

Abstract Objective: This study was to explore the clinical role of serum trophoblast cell surface protein 2 (TROP2) antibody in patients with non-small-cell lung cancer (NSCLC). Materials and methods: We collected serum specimens from 117 NSCLC patients, 40 benign lung disease patients, and 60 healthy controls. TROP2 antibody concentrations were measured using enzyme-linked immunosorbent assay. Results: Serum TROP2 antibody levels were higher in the NSCLC group compared to the control group (p < 0.001). TROP2 antibody, at a cutoff value of 9.8 U/ml, showed good diagnostic performance for NSCLC. Conclusion: Measurement of TROP2 antibody might have diagnostic value for patients with NSCLC.
Nove varijacije Munker-Whiteovoga efekta u grafičkoj komunikaciji = New variations of Munker-White effect in the process of graphical communication

U suvremenoj grafickoj komunikaciji intenzivno se proucavaju manifestacije raznovrsnih psihofizickih vizualnih efekata. Jedan od efekata koji se najcesce susrecu u grafickom dizajnu je Munker-Whiteov efekt. Ovaj je efekt uzrokovan obojenom geometrijskom strukturom koja se naziva Munker-Whiteova resetka i manifestira se kao ukupna razlika boja ( ) percipiranih pravokutnih elemenata resetke u odnosu na fizicku vrijednost boje. Pritom se najizraženije manifestira razlika percepcije svjetline ( ). U disertaciji su definirane nove varijacije akromatskog Munker-Whiteovog efekta. Kao testni uzorci koristene su nove varijacije resetki razlicitih postotaka pokrivenosti i razlicitih svjetlina. Nad uzorcima je proveden psihofizicki vizualni eksperiment u kojem je sudjelovalo 38 ispitanika. Ukupne razlike percipiranih boja u odnosu na njihove fizicke vrijednosti racunane su u CIE sustavu. Regresijskom analizom utvrđene su pravilnosti kojima se podvrgava Munker-Whiteov efekt. Rezultati su dobiveni uspoređivanjem razlicitih regresijskih modela, dok se ne dobiju oni modeli koji su najbolje prilagođeni rezultatima eksperimenta. Na taj je nacin pronađena kvadratna funkcijska ovisnost varijable u ovisnosti o parametru postotka pokrivenosti . Utvrđena je i kvadratna funkcijska povezanost varijable i svjetline pravokutnih elemenata . Pronađena je i paraboloidna funkcija koja daje ovisnost varijable o varijablama i . Ova se funkcija može smatrati vizualnim zakonom percepcije pravokutnih elemenata Munker-Whiteove resetke. Provedena je i logisticka regresijska analiza, napravljena za slucaj razlika koje promatraci primjecuju, vide, dobro vide i ocigledno razlikuju. Dobiveni logisticki regresijski modeli omogucavaju izracunavanje vjerojatnosti da ce promatrac uociti (primijetiti, vidjeti, dobro vidjeti i ocigledno razlikovati) Munker-Whiteov efekt na grafickim reprodukcijama u navedenim slucajevima. Svi dobiveni modeli statisticki su testirani te je dokazana njihova visoka statisticka kakvoca. Utvrđeni matematicki modeli omogucavaju ucinkovito proracunavanje intenziteta kao i vjerojatnosti pojavljivanja Munker-Whiteovog efekta u raznim slucajevima te predstavljaju vrijedan doprinos suvremenoj grafickoj komunikaciji.
Fractional Precipitation of Plasma Proteome by Ammonium Sulphate: Case Studies in Leukemia and Thalassemia

Human plasma proteome is a comprehensive source of disease biomarkers. However, the >10 orders-wide dynamic concentration range of its constituent proteins necessitates depletion of abundant proteins from plasma prior to biomarker discovery. Our objective has been to develop a simple method that would deplete the most abundant proteins e.g. albumin and immunoglobulins, effectively facilitating identification of differentially regulated proteins in plasma samples. We employed ammonium sulphate based pre-fractionation of plasma followed by twodimensional gel electrophoresis (2DGE) for comparison of normal proteins with those from the plasma samples of the patients, after identification of proteins by MALDI-TOF/TOF tandem mass spectrometry. Fractional precipitation of the plasma samples by 20% ammonium sulphate from raw plasma doubled the number of protein spots after 2DGE and led to identification of 87 unique proteins, including several low-abundance proteins. Case studies done with fractional precipitation of the plasma samples of patients suffering from hematological diseases e.g. leukemia and thalassemia indicate the utility of such pre-fractionation in the detection of differentially regulated proteins.
Density-viscosity sensor based on piezoelectric MEMS resonator and oscillator circuit

There are many examples of physical sensing in liquid employing resonators, especially involving TSM quartz crystals. Nevertheless, to determine density and viscosity independently, out-of-plane vibration modes are required, what typically results in low quality factors. Non-fundamental out-of-plane vibration modes have not been deeply studied for this application. Here we demonstrate the benefit of the 2nd-order mode of a microplate. In addition, the device needs to be electronically interfaced in order to measure its resonant characteristics that are ultimately translated into density and viscosity. For this, we have implemented an oscillator circuit with discrete components, which supposes a novelty regarding piezoelectric microstructures immersed in liquid. As a result, we present for the first time a complete density-viscosity sensor system based on a MEMS resonator embedded in low-cost circuitry. The sensitivities involved are evaluated, along with the resolutions for density and viscosity, below 4.09·10-6 g/ml and 2.07·10-6 mPa·s respectively.
Study on Data Security of Cloud Computing

Data security is one of the leading concerns and primary challenges for cloud computing. This issue is getting more and more serious with the cloud computing became popular. Once users data is uploaded, it must be drifted away from the user's control, and it is no longer security. In this paper, the nine key data security principles were analyzed in depth on the basis of a comprehensive summary of the data need to be protected. Finally, six key technologies of data security were proposed. All of these can guarantee the data security throughout the whole lifetime.