Miracle-dz/UniFAR-FTUs huggingface dataset:
A Device-Free Indoor Localization Method Using CSI with Wi-Fi Signals

Amid the ever-accelerated development of wireless communication technology, we have become increasingly demanding for location-based service; thus, passive indoor positioning has gained widespread attention. Channel State Information (CSI), as it can provide more detailed and fine-grained information, has been followed by researchers. Existing indoor positioning methods, however, are vulnerable to the environment and thus fail to fully reflect all the position features, due to limited accuracy of the fingerprint. As a solution, a CSI-based passive indoor positioning method was proposed, Wavelet Domain Denoising (WDD) was adopted to deal with the collected CSI amplitude, and the CSI phase information was unwound and transformed linearly in the offline phase. The post-processed amplitude and phase were taken as fingerprint data to build a fingerprint database, correlating with reference point position information. Results of experimental data analyzed under two different environments show that the present method boasts lower positioning error and higher stability than similar methods and can offer decimeter-level positioning accuracy.
Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

The aim of this study was to perform a systematic review of the literature followed by a meta-analysis about the efficacy of photodynamic therapy (PDT) on the microorganisms responsible for dental caries. The research question and the keywords were constructed according to the PICO strategy. The article search was done in Embase, Lilacs, Scielo, Medline, Scopus, Cochrane Library, Web of Science, Science Direct, and Pubmed databases. Randomized clinical trials and in vitro studies were selected in the review. The study was conducted according the PRISMA guideline for systematic review. A total of 34 articles were included in the qualitative analysis and four articles were divided into two subgroups to perform the meta-analysis. Few studies have achieved an effective microbial reduction in microorganisms associated with the pathogenesis of dental caries. The results highlight that there is no consensus about the study protocols for PDT against cariogenic microorganisms, although the results showed the PDT could be a good alternative for the treatment of dental caries.
Pharmacologic Activation of Lytic Epstein-Barr Virus Gene Expression without Virion Production

Epstein-Barr virus is associated with many different cancers. In these cancers the viral genome is predominantly latent; i.e., most viral genes are not expressed, most viral proteins are not synthesized, and new virions are not produced. Some strategies for treating these cancers involve activation of lytic viral gene expression. We identify an antibacterial antibiotic, clofoctol, that is an activator of EBV lytic RNA and protein expression but that does not lead to virion production. ABSTRACT Several therapeutic strategies targeting Epstein-Barr virus (EBV)-associated tumors involve upregulation of viral lytic gene expression. Evidence has been presented that the unfolded protein response (UPR) leads to EBV lytic gene expression. Clofoctol, an antibacterial antibiotic, has been reported to upregulate the UPR in prostate cancer cell lines and to slow their growth. We investigated the effects of clofoctol on an EBV-positive Burkitt lymphoma cell line and confirmed the upregulation of all three branches of the UPR and activation of EBV lytic gene expression. While immediate early, early, and late EBV RNAs were all upregulated, immediate early and early viral proteins but not late viral proteins were expressed. Furthermore, infectious virions were not produced. The use of clofoctol in combination with a protein kinase R-like endoplasmic reticulum kinase inhibitor led to expression of late viral proteins. The effects of clofoctol on EBV lytic protein upregulation were not limited to lymphoid tumor cell lines but also occurred in naturally infected epithelial gastric cancer and nasopharyngeal cancer cell lines. An agent that upregulates lytic viral protein expression but that does not lead to the production of infectious virions may have particular value for lytic induction strategies in the clinical setting. IMPORTANCE Epstein-Barr virus is associated with many different cancers. In these cancers the viral genome is predominantly latent; i.e., most viral genes are not expressed, most viral proteins are not synthesized, and new virions are not produced. Some strategies for treating these cancers involve activation of lytic viral gene expression. We identify an antibacterial antibiotic, clofoctol, that is an activator of EBV lytic RNA and protein expression but that does not lead to virion production.
High-Altitude Acclimatization Improves Recovery from Muscle Fatigue.

PURPOSE We investigated the effect of high-altitude acclimatization on peripheral fatigue compared to sea level and acute hypoxia. METHODS At sea level (350 m), acute hypoxia (environmental chamber), and chronic hypoxia (5050 m, 5-9 days) (partial pressure of inspired oxygen = 140, 74 and 76 mmHg, respectively), 12 participants (11 in chronic hypoxia) had the quadriceps of their dominant leg fatigued by 3 bouts of 75 intermittent electrically-evoked contractions (12 pulses at 15 Hz, 1.6 s between train onsets, and 15 s between bouts). The initial peak force was ~30% of maximal voluntary force. Recovery was assessed by single trains at 1, 2, and 3 min post-protocol. Tissue oxygenation of rectus femoris was recorded by near-infrared spectroscopy. RESULTS At the end of the fatigue protocol, the impairments of peak force and peak rates of force development and relaxation were greater (all P < 0.05) in acute hypoxia (~51, 53 and 64%, respectively) than sea level (~43, 43 and 52%) and chronic hypoxia (~38, 35 and 48%). Peak force and rate of force development recovered faster (P < 0.05) in chronic hypoxia (pooled data for 1-3 min: ~84 and 74% baseline, respectively) compared to sea level (~73 and 63% baseline) and acute hypoxia (~70 and 55% baseline). Tissue oxygenation did not differ among conditions for fatigue or recovery (P > 0.05). CONCLUSION Muscle adaptations occurring with chronic hypoxia, independent of other adaptations, positively influence muscle contractility during and after repeated contractions at high altitude.
Mammalian target of rapamycin inhibitors combined with calcineurin inhibitors as initial immunosuppression in renal transplantation: a meta-analysis.

BACKGROUND The current standard of care immunosuppressive regimen in kidney transplantation (KT) includes a combination of mycophenolates (MMF/MPA) with a calcineurin inhibitor (CNI). METHODS We designed a systematic review including all randomized clinical trials (RCTs) assessing the outcomes in KT recipients receiving mTORi+CNI compared with regimens containing MMF/MPA or azathioprine with CNI. RESULTS A total of 24 studies with 7356 participants were included. The comparison of mTORi-CNI versus MMF/MPA-CNI did not show differences in acute rejection, mortality or graft loss rates. Better graft function was observed using MMF/MPA-CNI than using mTORi+CNI, but this difference was not evident when the mTORi was associated with reduced dose CNI in more recent studies with everolimus. Dyslipidemia, lymphoceles and impaired wound healing were more frequent with mTORi-CNI and diarrhea and leukopenia more frequent with MMF/MPA-CNI. Viral infections at any time and malignant neoplasia beyond 2 years were less frequent with mTORi-CNI. Rates of discontinuation due to adverse effects in the mTORi groups varied between 17% and 46% compared to 0-26.6% in MMF/MPA groups. The current use of lower mTORi dosage has decreased discontinuation rates. CONCLUSIONS Efficacy is similar with mTORi+CNI and MMF/MPA-CNI. The safety profile is the predominant difference between the two regimens.
Information granulation in natural language syntactical approach

--This paper introduces a new framework for processing Natural Language statements. The parallel is drawn between the Natural Language processing and the Data Mining technology of information granulation. The formalism affords consistent representation of a well-known phenomenon of ‘approximate’ grammatical correctness of Natural Language statements. The approach is validated on some simple Natural Language statements and the directions for the future development of the system are outlined.
Environmental Toxicology and Chemistry

Wetland environments provide numerous ecosystem services but also facilitate methylmercury (MeHg) production and bioaccumulation. We developed a wetland‐management technique to reduce MeHg concentrations in wetland fish and water. We physically modified seasonal wetlands by constructing open‐ and deep‐water treatment cells at the downstream end of seasonal wetlands to promote naturally occurring MeHg‐removal processes. We assessed the effectiveness of reducing mercury (Hg) concentrations in surface water and western mosquitofish that were caged at specific locations within 4 control and 4 treatment wetlands. Methylmercury concentrations in wetland water were successfully decreased within treatment cells during only the third year of study; however, treatment cells were not effective for reducing total Hg concentrations. Furthermore, treatment cells were not effective for reducing total Hg concentrations in wetland fish. Mercury concentrations in fish were not correlated with total Hg concentrations in filtered, particulate, or whole water; and the slope of the correlation with water MeHg concentrations differed between months. Fish total Hg concentrations were weakly correlated with water MeHg concentrations in April when fish were introduced into cages but were not correlated in May when fish were retrieved from cages. Fish total Hg concentrations were greater in treatment wetlands than in control wetlands the year after the treatment wetlands’ construction but declined by the second year. During the third year, fish total Hg concentrations increased in both control and treatment wetlands after an unexpected regional flooding event. Overall, we found limited support for the use of open‐ and deep‐water treatment cells at the downstream end of wetlands to reduce MeHg concentrations in water but not fish. We suggest that additional evaluation over a longer period of time is necessary. Environ Toxicol Chem 2019;38:2178–2196. Published 2019 Wiley Periodicals, Inc. on behalf of SETAC. This article is a US government work, and as such, is in the public domain in the United States of America.
Sustained Progression-Free Survival Benefit of Rituximab Maintenance in Patients With Follicular Lymphoma: Long-Term Results of the PRIMA Study

PURPOSE The PRIMA study (ClinicalTrials.gov identifier: NCT00140582) established that 2 years of rituximab maintenance after first-line immunochemotherapy significantly improved progression-free survival (PFS) in patients with follicular lymphoma compared with observation. Here, we report the final PFS and overall survival (OS) results from the PRIMA study after 9 years of follow-up and provide a final overview of safety. METHODS Patients (> 18 years of age) with previously untreated high–tumor-burden follicular lymphoma were nonrandomly assigned to receive one of three immunochemotherapy induction regimens. Responding patients were randomly assigned (stratified by induction regimen, response to induction treatment, treatment center, and geographic region) 1:1 to receive 2 years of rituximab maintenance (375 mg/m2, once every 8 weeks), starting 8 weeks after the last induction treatment, or observation (no additional treatment). All patients in the extended follow-up provided their written informed consent (data cutoff: December 31, 2016). RESULTS In total, 1,018 patients completed induction treatment and were randomly assigned to rituximab maintenance (n = 505) or observation (n = 513). Consent for the extended follow-up was provided by 607 patients (59.6%) of 1,018 (rituximab maintenance, n = 309; observation, n = 298). After data cutoff, median PFS was 10.5 years in the rituximab maintenance arm compared with 4.1 years in the observation arm (hazard ratio, 0.61; 95% CI, 0.52 to 0.73; P < .001). No OS difference was seen in patients randomly assigned to rituximab maintenance or observation (hazard ratio, 1.04; 95% CI, 0.77 to 1.40; P = .7948); 10-year OS estimates were approximately 80% in both study arms. No new safety signals were observed. CONCLUSION Rituximab maintenance after induction immunochemotherapy provides a significant long-term PFS, but not OS, benefit over observation.
Response of gastrointestinal fermentative activity and colonic microbiota to protected sodium butyrate and protected sodium heptanoate in weaned piglets challenged with ETEC F4+

ABSTRACT This study aimed to evaluate the potential of two new fat-protected butyrate or heptanoate salts to improve gut health and control post-weaning colibacillosis in weaning piglets challenged with enterotoxigenic Escherichia coli (ETEC) F4+, particularly focusing on their impact on intestinal microbiota and fermentative activity along the gastrointestinal tract (GIT). Seventy-two 21-d-old pigs were fed a plain diet (CTR) or supplemented with sodium butyrate (BUT) or sodium heptanoate (HPT), both at 0.3%. After a week of adaptation, animals were orally challenged at days 8 and 9 with 5.8 · 109 and 6.6 · 1010 cfu, respectively, and were euthanised on d 4 and d 8 post-inoculation (PI) (n = 8) to collect blood, digesta and tissue samples and characterise microbial groups, pathogen loads (qPCR), fermentation, ileal histomorphometry and immune markers. Colonic microbiota was analysed by 16S rRNA gene MiSeq sequencing. Supplementing both acid salts did not compensate clinical challenge effects nor performance impairments and neither histomorphometry nor serum biomarkers. Changes in the gastric fermentative activity were registered, BUT reducing lactic acid concentrations (day 8 PI), and with HPT fewer animals presenting detectable concentrations of propionic, butyric and valeric acids. At ileum BUT increased acetic acid concentration (day 8 PI), and both additives reduced short-chain fatty acids (SCFA) in the colon. Increases in enterobacteria and coliforms counts in ileal digesta (day 4 PI, p < 0.10) and mucosa scrapes (p < 0.05) were registered although E. coli F4 gene copies were unaffected. Regarding changes in the colonic microbiota (day 4 PI), Prevotellaceae and Prevotella were promoted with BUT supplementation whereas only minor groups were modified in HPT-treated animals. Summarising, although the pathogen loads or inflammatory mediators remained unresponsive, butyrate and heptanoate showed a significant impact on microbial fermentation along the whole GIT, being able to modify different bacterial groups at the colon. It could be hypothesised that these effects might be mediated by a carry-over effect of the changes observed in gastric fermentation, but possibly also to a better nutrient digestion in the foregut as a result of the reduced colonic SCFA concentrations.
Preventive parent-young child interaction interventions to promote optimal attachment.

PURPOSE OF REVIEW Quality of attachment relationships is believed to be an important early indicator of infant mental health as it is considered a vital component of social and emotional development in the early years. As a result, there has been a growing call for the development of early intervention attachment research programs. In this brief overview, we summarize what we consider to be the state-of-the-art of intervention programs targeted to increase the prevalence of secure attachment and to reduce the level of disorganized attachment among infants with a wide range of psychological risks. RECENT FINDINGS The themes in the literature covered by the article are as follows: recent results of the main preventive parent-young child interaction interventions to promote optimal attachment; recent metaanalysis on efficiency of these early attachment-based programs; intermediate variables on intervention effects; and benefits of specific therapeutic approaches focused on maternal psychopathology. Globally, early attachment-informed interventions show positive effects, both for mothers and infants. SUMMARY Our revision stresses the importance of formally assessing the underlying mechanisms of change within interventions in research programs to open the path to improve and target these preventive approaches and consequently promote optimal attachment.
A new approach to operational semantics by categories

Structural operational semantics is one of the most popular semantic methods in the community of software engineers. It describes program behavior in the form of change of states caused by execution of elementary steps. This feature predestinates Structural operational semantics for implementation of programming languages and also for verification purposes. In our paper we present a new approach to Structural operational semantics: behavior of programs, i.e. state changes we model in category of states. Category morphisms express elementary execution steps and program execution is an oriented path in category, i.e. composition of morphisms. Our approach is able to accentuate dynamics of Structural operational semantics, it is intuitively typed. That's why such model is suitable not only as a model for Structural operational semantics but also for educating young software engineers.
Apoptosis Induction and Alteration of Cell Adherence in Human Lung Cancer Cells under Simulated Microgravity

Background: Lung cancer cells are known to change proliferation and migration under simulated microgravity. In this study, we sought to evaluate cell adherence, apoptosis, cytoskeleton arrangement, and gene expression under simulated microgravity. Methods: Human lung cancer cells were exposed to simulated microgravity in a random-positioning machine (RPM). Cell morphology and adherence were observed under phase-contrast microscopy, cytoskeleton staining was performed, apoptosis rate was determined, and changes in gene and protein expression were detected by real-time PCR with western blot confirmation. Results: Three-dimensional (3D)-spheroid formation was observed under simulated microgravity. Cell viability was not impaired. Actin filaments showed a shift in alignment from longitudinal to spherical. Apoptosis rate was significantly increased in the spheroids compared to the control. TP53, CDKN2A, PTEN, and RB1 gene expression was significantly upregulated in the adherent cells under simulated microgravity with an increase in corresponding protein production for p14 and RB1. SOX2 expression was significantly upregulated in the adherent cells, but protein was not. Gene expressions of AKT3, PIK3CA, and NFE2L2 remained unaltered. Conclusion: Simulated microgravity induces alteration in cell adherence, increases apoptosis rate, and leads to upregulation of tumor suppressor genes in human lung cancer cells.
[Role of miRNA-340 in modulating gastric cancer cell proliferation and bioinformatic analysis].

OBJECTIVE To investigate the mechanism of miRNA-340 for regulating the proliferation of gastric cancer (GC) cells and predict its interacting circular RNAs (circRNAs), its downstream target genes and the involved signaling pathways. METHODS The differentially expressed miRNAs in GC cell lines were analyzed and screened using miRNA microarrays. The expression level of miRNA-340 in 21 pairs of GC tissues and adjacent normal tissues was detected using real-time PCR. MTT and EdU assays were performed to examine the effect of miRNA-340 on the proliferation ability of HFE145 and BGC-823 cells. We also tested the effect of miRNA-340 inhibition on subcutaneous tumorigenesis of GC cells in a nude mouse model. The downstream target genes of miRNA-340 and the probable signal pathways were predicted online using Targetscan and DAVID database, respectively. The interacting circRNAs of miRNA-340 were analyzed using starBase platform. RESULTS Among the differentially expressed miRNAs, miRNA-340 was significantly down-regulated in GC cell lines. Real-time PCR results showed that the expression of miRNA-340 was significantly lower in GC tissues than in the adjacent tissues (P < 0.05). MTT and EdU cell proliferation assays showed that miRNA-340 overexpression inhibited the proliferation of GC cells in vitro. In the nude mouse models, the proliferation of GC cells transfected with miRNA-340 inhibitor was obviously enhanced. Bioinformatics analysis suggested that miRNA-340 had 21 target genes with 3 or more conserved sites, and these genes were involved in tumorigenesis and invasion. The top 10 circRNAs were selected as the most powerful sponge circRNAs interacting with miRNA-340. CONCLUSIONS miRNA-340 may play the role of a tumor suppressor in tumorigenesis and progression. Overexpression of miRNA-340 suppress the proliferation of GC cells, suggesting its involvement in the development of GC along with multiple circRNAs.
Class I small leucine-rich proteoglycans (SLRPs) colocalise with the Aβ2M amyloid deposits: implications for the roles of SLRP core proteins in the pathogenesis of dialysis-related amyloidosis

Itaru Yamaguchi, Yasuo Kokubo, Taro Yamashita, Mitsuharu Ueda, Tadakazu Okoshi, Akihiko Matsumine, Yukio Ando and Hironobu Naiki Department of Molecular Pathology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan; Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Accurate Statistical Workload Modeling.

Designing a new microprocessor is a complex process taking several years from start to finish. Even the earliest stages of the design cycle, namely defining the microarchitecture, can take several months, if not years. Our work deals with increasing the efficiency of these early design phases: selecting representative program-input pairs, efficient design space exploration, incorporating the impact of technology, etc. This abstract gives an overview of the major issues concerning the earliest stages of the design process and details on how our work contributes to these issues.
Maternal and child factors associated with child body fatness in a Ghanaian cohort

Abstract Objective: We aimed to identify factors (child diet, physical activity; maternal BMI) associated with body composition of Ghanaian pre-school children. Design: Longitudinal analysis of the International Lipid-Based Nutrient Supplements (iLiNS)-DYAD-Ghana randomized trial, which enrolled 1320 pregnant women at ≤20 weeks’ gestation and followed them and their infants until 6 and 18 months postpartum, respectively. At follow-up, child age 4–6 years, we collected data on body composition (by 2H dilution), physical activity and diet, extracted dietary patterns using factor analysis, and examined the association of children’s percentage body fat with maternal and child factors by regression analysis. Setting: Eastern Region, Ghana. Participants: Children 4–6 years of age. Results: The analysis included 889 children with percentage body fat and dietary data at follow-up. We identified two major dietary patterns, a snacking and a cooked foods pattern. Percentage body fat was positively associated (standardized β (se)) with maternal BMI at follow-up (0·10 (0·03); P = 0·003) and negatively associated with physical activity (−0·15 (0·05); P = 0·003, unadjusted for child gender), but not associated with the snacking (0·06 (0·03); P = 0·103) or cooked foods (−0·05 (0·07); P = 0·474) pattern. Boys were more active than girls (1470 v. 1314 mean vector magnitude counts/min; P < 0·0001) and had lower percentage body fat (13·8 v. 16·9 %; P < 0·0001). Conclusions: In this population, maternal overweight and child physical activity, especially among girls, may be key factors for addressing child overweight/obesity. We did not demonstrate a relationship between the dietary patterns and body fatness, which may be related to limitations of the dietary data available.