Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute myeloid leukemia as the first hematologic manifestation of fanconi anemia

A six‐year‐old girl with Fanconi anemia (FA) developed acute myeloid leukemia (AML) as the first hematologic manifestation of the syndrome. She remains in remission 18 mo after diagnosis although her management is complicated by unusual sensitivity to chemotherapeutic agents. Marrow cells studied prior to initiation of leukemia therapy showed increased chromosome breakage and an abnormal clone in which a number 7 and a number 8 chromosome were replaced by two marker chromosomes. During the present remission her cultured lymphocytes, bone marrow cells, and fibroblasts showed increased “spontaneous” chromosome breakage as well as enhanced sensitivity to the clastogenic effect of the difunctional alkylating agent diepoxybutane (DEB), features characteristic of FA. Eight months into remission 50% of her marrow cells comprised an abnormal clone, which was monosomic for the number 7 chromosome but had both copies of number 8; in addition a variable number of unique marker chromosomes were present in clonal as well as nonclonal cells. This same marrow sample, upon culture, showed an abnormal growth pattern of CFU‐GM, absence of detectable CFU‐GEMM and BFUe, non‐responsiveness of CFU‐GM to inhibition by acidic isoferritins, increased bone marrow acidic isoferritin inhibitory activity, and absence of detectable bone marrow cell‐derived GM‐CSF. The implications of these findings to leukemogenesis in FA are discussed.
Animal personality: what are behavioural ecologists measuring?

The discovery that an individual may be constrained, and even behave sub‐optimally, because of its personality type has fundamental implications for understanding individual‐ to group‐level processes. Despite recent interest in the study of animal personalities within behavioural ecology, the field is fraught with conceptual and methodological difficulties inherent in any young discipline. We review the current agreement of definitions and methods used in personality studies across taxa and systems, and find that current methods risk misclassifying traits. Fortunately, these problems have been faced before by other similar fields during their infancy, affording important opportunities to learn from past mistakes. We review the tools that were developed to overcome similar methodological problems in psychology. These tools emphasise the importance of attempting to measure animal personality traits using multiple tests and the care that needs to be taken when interpreting correlations between personality traits or their tests. Accordingly, we suggest an integrative theoretical framework that incorporates these tools to facilitate a robust and unified approach in the study of animal personality.
Cloud Standby System and Quality Model

http://hipore.com/ijcc 48 CLOUD STANDBY SYSTEM AND QUALITY MODEL Alexander Lenk, Frank Pallas FZI Forschungszentrum Informatik Friedrichstr. 60, 10117 Berlin, Germany {lenk, pallas}@fzi.de Abstract Contingency plans for disaster preparedness and concepts for resuming regular operation as quickly as possible have been an integral part of running a company for decades. Today, large portions of revenue generation are taking place over the Internet and it has to be ensured that the respective resources and processes are secured against disasters, too. Cloud‐Standby‐Systems are a way for replicating an IT infrastructure to the Cloud. In this work, the Cloud Standby approach and a Markov‐based model is presented that can be used to analyze and configure Cloud Standby systems on a long term basis. It is shown that by using a Cloud‐Standby‐System the availability can be increased, how configu‐ ration parameters like the replication interval can be optimized, and that the model can be used for supporting the decision whether the infrastructure should be replicated or not.
Cardiac dysfunction in acromegaly: evidence by pulsed wave tissue Doppler imaging.

OBJECTIVE To verify whether the accuracy of data on myocardial function provided by pulsed-wave tissue Doppler imaging (PWTDI), a new echocardiographic application that allows quantitative measurements of myocardial wall velocities, could help towards a better understanding of the natural history of acromegalic cardiomyopathy. DESIGN Eighteen patients with active acromegaly (ten men and eight women; mean age 48.0+/-15.0 years) with no other detectable cause of heart disease underwent PWTDI. Thirteen healthy individuals matched for age and body mass index acted as a control group. METHODS Ejection fraction (EF), transmitral early/late diastolic velocity (E/A) ratio and isovolumic relaxation time (IVRT) were measured by conventional echocardiography; systolic peak (Sv) and early (Ev) and late (Av) diastolic peak velocities, Ev/Av ratio and regional IVRT (IVRTs) were obtained by PWTDI. RESULTS All patients showed appreciably abnormal left ventricular global diastolic function represented by prolongation of the IVRT (P<0.001). Using PWTDI we found a prolongation of IVRTs and inversion of the Ev/Av ratio. In addition, the Ev/Av ratio proved to be significantly negatively correlated with IVRT; this correlation was not present in the case of the E/A ratio. Furthermore, a decrease in Sv was detected in the basal segment of the lateral wall (P<0.01), which had the greatest degree of diastolic dysfunction. CONCLUSIONS PWTDI confirmed the acknowledged diastolic dysfunction that accompanies acromegalic cardiomyopathy and highlighted the greater sensitivity of regional PWTDI with respect to global Doppler diastolic indexes. Furthermore, by revealing an impairment of regional systolic function in presence of a normal EF, the findings with PWTDI contradicted the largely accepted theory that systolic function remains normal for several years in patients affected by acromegalic cardiomyopathy.
Repression of Ribosome and tRNA Synthesis in Secretion-Defective Cells Is Signaled by a Novel Branch of the Cell Integrity Pathway

ABSTRACT The transcription of ribosomal DNA, ribosomal protein (RP) genes, and 5S and tRNA genes by RNA polymerases (Pols) I, II, and III, respectively, is rapidly and coordinately repressed upon interruption of the secretory pathway in Saccharomyces cerevisiae. We find that repression of ribosome and tRNA synthesis in secretion-defective cells involves activation of the cell integrity pathway. Transcriptional repression requires the upstream components of this pathway, including the Wsc family of putative plasma membrane sensors and protein kinase C (PKC), but not the downstream Bck1–Mkk1/2–Slt2 mitogen-activated protein kinase cascade. These findings reveal a novel PKC effector pathway that controls more than 85% of nuclear transcription. It is proposed that the coordination of ribosome and tRNA synthesis with cell growth may be achieved, in part, by monitoring the turgor pressure of the cell.
Incidence of Dementia in Very Elderly Individuals: A Clinical, Neuropathological and Molecular Genetic Study

Aims: To evaluate the effect of medical record use on figures for the incidence of dementia and the effect of apolipoprotein E (APOE) polymorphism on this incidence and neuropathologically defined Alzheimer’s disease (AD) in very elderly individuals. Methods: Cognitive functions were examined in a cohort of 328 (92% of the very elderly people of a town participated in this study) nondemented Finnish elderly individuals 85 years of age or more in 1991. The examination was repeated in survivors in 1994, 1996, 1999 and 2001. Medical notes and social work records were evaluated. All these individuals were genotyped for APOE. Neuropathological analysis of AD-type pathology was performed on 159 of 303 subjects who died during the follow-up. Results: Age group, gender or APOE did not significantly affect the incidence of dementia, which was over 20% higher (85 vs. 69 per 1,000 person-years) if the cognitive status at death was ascertained by medical and social work records than without this evaluation. The APOE υ4 allele was highly significantly (p = 0.002) and age almost significantly (p = 0.06) associated with neuropathological AD in nondemented individuals. Conclusions: Medical records should be analyzed in studies on the incidence of dementia in very elderly individuals. APOE polymorphism does not affect the incidence of dementia in this age group. However, clinical dementia diagnosis in very elderly individuals does not necessarily correlate well with the presence of neuropathological AD which, even in this age group, is significantly associated with the APOE υ4 allele.
Deregulation of mitosis progression and cytotoxic effect triggered in Allium cepa L. roots by Rubus sancatus schreber extract

Background and Aims: Medicinal plant extracts have been traditionally used in curing several diseases in folk medicine but several of them proved to cause cellular changes in many vital systems. Family Rosaceae demonstrated different biological activities in several previous investigations. The present study aims to assess the cytological and cellular effect of different concentrations of Rubus sanctus Schreber aqueous alcoholic extract (RsAAE) on Allium cepa L. root meristems using different techniques. Material and Methods: Cytological and cellular effect of different concentrations (1, 5& 10 mg mL -1 ) of RsAAE for different duration of administration (3, 6& 12h) on A. cepa L. root cells were studied using mitotic, ultrastructural and biochemical analyses. Result: The administration of different concentrations of RsAAE for different periods of exposure exhibited suppression of the mitotic and cell cycle progression on A. cepa root meristems. Several mitotic abnormalities were recorded. RsAAE enhanced deleterious changes on the cellular organelles of A. cepa root meristems leading to autolysis of the cells. Gene expression was changed as 10 de novo bands were produced as well as several bands were disappeared, these alterations were associated with a drastic inhibition of protein content. Discussion: The present study declared the prevalence mitostatic and cytotoxic effect of RsAAE on A. cepa root meristems. In spite of R. sanctus has valuable effects as a medicinal herb, it can enhance severe complications and destruction on the normal cells when it is used indecorously. (Sobieh Shaimaa Selmi, Tawab Sahar Abdelfattah and Fahmy Dina Mostafa. Deregulation of Mitosis Progression and Cytotoxic Effect Triggered in Allium Cepa L. Roots by Rubus Sancatus Schreber Extract. Life Sci J 2014;11(11):1047-1058). (ISSN:1097-8135). http://www.lifesciencesite. com. 181
Ignition of a Rectangular Solid by an External Heat Flux

The influence of corners on the ignition of a solid exposed to a surface energy flux is analyzed with large activation energy asymptotics. We begin with the analysis of the ignition of semi-infinite wedges by a constant heat flux. Two stages and two spatial zones, reactive and inert, are found. The ignition stage can be described by a slowly convergent asymptotic expansion for the increment in temperature due to the chemical reaction or, more accurately, by a simplified nonlinear parabolic equation to be solved numerically. This analysis applies to the ignition of two-dimensional finite bodies with corners if the external heat flux is large enough for the size of the reaction zone to be much smaller than that of the solid. The ignition of bodies with rectangular shape for small heat fluxes, when the reaction zone extends to the whole solid, is also analyzed.
THE FULL-BAND AND SUB-BAND SYSTEMS , ADAPTIVE COMBINATION OF SUB BAND ADAPTIVE FILTERS

1 Al-Falah School Of Engg. &Tech., Hayarana, India 2 Al-Falah School Of Engg. &Tech., Hayarana, India 3 ECE, SDEC, MTU,Noida,(India) Abstract: Communication technology has advanced to the point where teleconferences that use communication lines to connect remote conference rooms are taking place every day. The use of a centralized acoustic echo canceller in the mobile switching center of a GSM network allows the operator to enhance the audio quality before transmission to all subscribers. However, the main problem is the impact of the speech coder/decoder nonlinearities along the echo path. In this paper, we propose a combined acoustic echo canceller/post-filter based on perceptual properties to reduce the coding noise. Theoretical and experimental comparisons against classical solutions are given to evaluate the performance of the proposed approach in a centralized context of echo cancellation. Echo is the time delayed version of the original signal. Acoustic echo results from a feedback path set up between the speaker and the microphone in a mobile phone, hands-free phone . Echo can degrade the quality of service in telecommunication. Therefore echo cancellation is an important part of communication systems. A new approach based on the number of coefficients in an adaptive finite impulse response filter based acoustic echo cancellation setup is an important parameter, affecting the overall performance of the echo cancellation. Too few coefficients give under modeling and too many cause slow convergence and an additional echo due to the mismatch of the extra coefficients This paper focuses on the use of adaptive filtering techniques to cancel this unwanted echo thus increasing communication quality
A real-time streamline-based obstacle avoidance system for curvature-constrained nonholonomic mobile robots

This work presents a streamline-based strategy for curvature-constrained nonholonomic robots to safely navigate in real-world partially unknown environments with static cylinder-shaped obstacles whose locations are detected on-line. We propose the use of three primitive curvature-constrained collision-free paths derived from the manipulation and search of streamlines generated from harmonic potential function of a stationary circle. The primitive paths allow emergent turning and reduce the clearance with an obstacle. Assuming enough clearances between adjacent obstacles, the algorithm is extended to avoid multiple cylinder obstacles by pursuing a primitive path based on lateral distance of the robot and the closest obstacle, which can be calculated and updated in real time using pure pursuit tracker. Experiments validate that the obstacle avoidance system allows a two-wheel driving mobile robot to on-line navigate safely along a path without violating curvature constraint in partially unknown cluttered environments.
The forward problem and corrections for the SSM/T satellite microwave temperature sounder

The relationship between atmospheric temperatures and the brightness temperatures measured by the Special Sensor Microwave/Temperature (SSM/T) radiometer is addressed. Physical algorithms for retrieving temperature profiles explicitly employ the physics of radiative transfer. Consequently, it is necessary to do the forward problem accurately before attempting the retrieval problem. The various problems that arise in doing forward calculations over oceans are discussed. These problems include determining when the measurements are cloud contaminated, the amount of liquid water in the fields of view, the surface emissivity under both clear and cloudy conditions, the corrections for liquid water contamination of the measurements, the adjustments for deficiencies in the radiative transfer model, and the compensation for measurement discrepancies by using shrinkage estimation. These procedures are developed for SSM/T data, and their validity is checked by comparing the forward calculations with the corresponding satellite measurements. Application of the procedures to an independent data set confirms their veracity. >
Pharmacokinetics of ponazuril after oral administration to healthy llamas (Lama glama).

OBJECTIVE To determine the pharmacokinetics after oral administration of a single dose of ponazuril to healthy llamas. ANIMALS 6 healthy adult llamas. PROCEDURES Ponazuril (20 mg/kg) was administered once orally to 6 llamas (day 0). Blood samples were obtained on days 0, 0.5, 1, 2, 3, 4, 5, 6, 7, 9, 11, 14, 21, 28, 35, 42, and 49. Serum ponazuril concentrations were determined by use of a validated reverse-phase high-performance liquid chromatography assay with UV absorbance detection. Pharmacokinetic parameters were derived by use of a standard noncompartmental pharmacokinetic analysis. RESULTS Mean ± SD area under the serum concentration-time curve was 7,516 ± 2,750 h•mg/L, maximum serum ponazuril concentration was 23.6 ± 6.0 mg/L, and the elimination half-life was 135.5 ± 16.7 hours. Serum concentration of ponazuril peaked at 84 hours (range, 48 to 120 hours) after administration and gradually decreased but remained detectable for up to 35 days after administration. No adverse effects were observed during the study period. CONCLUSIONS AND CLINICAL RELEVANCE The rate and extent of absorption following oral administration of a single dose of ponazuril were sufficient to result in potentially effective concentrations, and the drug was tolerated well by llamas. At this dose, ponazuril resulted in serum concentrations that were high enough to be effective against various Apicomplexans on the basis of data for other species. The effective ponazuril concentration that will induce 50% inhibition of parasite growth for Eimeria macusaniensis in camelids is currently unknown.
Compact Multimode Patch Antennas for MIMO Applications [Wireless Corner]

This work presents the design of compact multimode patch antennas for application in medium-size MIMO terminals combining spatial and radiation-pattern diversity. This design was inspired by previous work, which proposed the use of patch antennas providing two services at two frequency bands that required different radiation patterns. These precedents are briefly reviewed, before extending the concept of the dual-pattern two-frequency case to one in which diversity is demanded at a single frequency. A design with three modes at a single frequency is also accomplished. Some prototypes have been manufactured and measured. An example of the advantages of using these multimode antennas in terms of spectral efficiency in MIMO systems is also included. The key aspect of this work is the use of short-circuited ring patch (SCRP) antennas.
Safe and effective dosing of basal-bolus insulin in patients receiving high-dose steroids for hyper-cyclophosphamide, doxorubicin, vincristine, and dexamethasone chemotherapy.

BACKGROUND Hyperglycemia occurs in cancer patients receiving high-dose steroids with cyclophosphamide, doxorubicin, vincristine, and dexamethasone (hyper-CVAD) protocol. The purpose of our study was to determine insulin requirements in patients with hyperglycemia on hyper-CVAD therapy using a systematic algorithm. SUBJECTS AND METHODS We did a retrospective chart review of 23 leukemia inpatients with hyperglycemia (two glucose values >250 mg/dL) on hyper-CVAD chemotherapy managed by the Endocrine Diabetes Inpatient Team algorithm. We reviewed demographic and glycemic data, insulin dosages, and use of oral hypoglycemic agents. Using our algorithm, the dose of insulin for each patient was titrated daily and with each subsequent cycle of hyper-CVAD. RESULTS Ninety-one percent of patients had known diabetes. The median body mass index was 32.5 (range, 21.6-40.9) kg/m², and median age was 61 (range, 40-80) years. The overall trend in glucose values across cycles showed a statistically significant decrease with each subsequent cycle of hyper-CVAD. Hyperglycemia accounted for 81% of glucose measurements in the first cycle and 60% of glucose values in the last cycle. Patients received 1-1.3 units/kg of insulin per cycle, and insulin requirements were similar across cycles. The distribution of basal versus bolus insulin for each cycle was 63-77% prandial and 23-37% basal. Nine of the 23 patients had at least one glucose value <70 mg/dL, which accounted for 1.3% of all recorded glucose values. None of the patients had severe hypoglycemia. CONCLUSIONS Multiple-dose insulin therapy initiated at 1-1.2 units/kg/day, distributed as 25% basal and 75% prandial, reduced hyperglycemia in patients who were receiving high-dose dexamethasone as part of hyper-CVAD.
The critical role of the ZNF217 oncogene in promoting breast cancer metastasis to the bone

Bone metastasis affects >70% of patients with advanced breast cancer. However, the molecular mechanisms underlying this process remain unclear. On the basis of analysis of clinical datasets, and in vitro and in vivo experiments, we report that the ZNF217 oncogene is a crucial mediator and indicator of bone metastasis. Patients with high ZNF217 mRNA expression levels in primary breast tumours had a higher risk of developing bone metastases. MDA‐MB‐231 breast cancer cells stably transfected with ZNF217 (MDA‐MB‐231‐ZNF217) showed the dysregulated expression of a set of genes with bone‐homing and metastasis characteristics, which overlapped with two previously described ‘osteolytic bone metastasis’ gene signatures, while also highlighting the bone morphogenetic protein (BMP) pathway. The latter was activated in MDA‐MB‐231‐ZNF217 cells, and its silencing by inhibitors (Noggin and LDN‐193189) was sufficient to rescue ZNF217‐dependent cell migration, invasion or chemotaxis towards the bone environment. Finally, by using non‐invasive multimodal in vivo imaging, we found that ZNF217 increases the metastatic growth rate in the bone and accelerates the development of severe osteolytic lesions. Altogether, the findings of this study highlight ZNF217 as an indicator of the emergence of breast cancer bone metastasis; future therapies targeting ZNF217 and/or the BMP signalling pathway may be beneficial by preventing the development of bone metastases. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Guideline concordant monitoring of metabolic risk in people treated with antipsychotic medication: systematic review and meta-analysis of screening practices

Background Despite increased cardiometabolic risk in individuals with mental illness taking antipsychotic medication, metabolic screening practices are often incomplete or inconsistent. Method We undertook a systematic search and a PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) meta-analysis of studies examining routine metabolic screening practices in those taking antipsychotics both for patients in psychiatric care before and following implementation of monitoring guidelines. Results We identified 48 studies (n=290 534) conducted between 2000 and 2011 in five countries; 25 studies examined predominantly schizophrenia-spectrum disorder populations; 39 studies (n=218 940) examined routine monitoring prior to explicit guidelines; and nine studies (n=71 594) reported post-guideline monitoring. Across 39 studies, routine baseline screening was generally low and above 50% only for blood pressure [69.8%, 95% confidence interval (CI) 50.9–85.8] and triglycerides (59.9%, 95% CI 36.6–81.1). Cholesterol was measured in 41.5% (95% CI 18.0–67.3), glucose in 44.3% (95% CI 36.3–52.4) and weight in 47.9% (95% CI 32.4–63.7). Lipids and glycosylated haemoglobin (HbA1c) were monitored in less than 25%. Rates were similar for schizophrenia patients, in US and UK studies, for in-patients and out-patients. Monitoring was non-significantly higher in case-record versus database studies and in fasting samples. Following local/national guideline implementation, monitoring improved for weight (75.9%, CI 37.3–98.7), blood pressure (75.2%, 95% CI 45.6–95.5), glucose (56.1%, 95% CI 43.4–68.3) and lipids (28.9%, 95% CI 20.3–38.4). Direct head-to-head pre–post-guideline comparison showed a modest but significant (15.4%) increase in glucose testing (p=0.0045). Conclusions In routine clinical practice, metabolic monitoring is concerningly low in people prescribed antipsychotic medication. Although guidelines can increase monitoring, most patients still do not receive adequate testing.