Miracle-dz/UniFAR-FTUs huggingface dataset:
Incidental Radiology Findings: Effectiveness of a Radiology-Electronic Medical Records Interface System for Improving Communication

Vol. 19, No. 3 March 2012 JCOM 111 AbstrAct • Objective: To report on a quality assurance program to improve communication with regard to radiologic findings. • Methods: Quality improvement report. • Results: Incidental findings requiring follow-up are common occurrences, particularly for thoracoabdominal CT scans. We found that many of these findings do not have a follow-up plan documented in the medical record. We significantly improved the rate of documented communication using technology that recognizes text strings in the radiology report. • Conclusion: An automated system of recognizing incidental findings notations in the radiology reports through an electronic medical records system that generated reports to clinicians and letters to patients improves patient safety.
A PHASE 3 TRIAL OF GVAX IMMUNOTHERAPY FOR PROSTATE CANCER VS. DOCETAXEL PLUS PREDNISONE IN ASYMPTOMATIC, CASTRATION-RESISTANT PROSTATE CANCER (CRPC)

� The intent-to-treat analysis of overall survival wa s performed on a dataset of 621 patients containing 371 deaths, le ss than the 400 pre-specified to obtain 80% power. The Kaplan- Meier curves appear to show no meaningful difference in t he pattern of survival between the two arms. The hazard ratio wa s 1.01, 95% CI (0.83, 1.28), p=0.78 (stratified log-rank test) suggesting no difference between the two treatment arms. The Kaplan-Meier curve for Arm G crosses above the Arm D+P curve at approximately 21 months, suggesting a late possibly favorable effect of the immunotherapy. � Additional survival analyses were conducted to dete rmine whether some subgroups of patients may show greater benefit from immunotherapy. In the subgroup of patients wi th a predicted survival time � 18 months at baseline, based on the Halabi nomogram, the hazard ratio was 0.90 (95% CI: 0.61,1.33). This suggests that immunotherapy may p rovide a survival benefit compared to chemotherapy in this p atient group. � In Arm G, 69% of patients received subsequent docet axel following immunotherapy, and 26% had either no addi tional therapy or had treatments not established to have a n impact on survival in metastatic HRPC. Data on subsequent th erapies was not available for 5% of patients.
TQE: Transcription Quality Evaluation

The current proposal is about a completely automatic Transcription Quality Evaluation (TQE) tool. Input is a corpus with audio files and phone transcriptions (PTs). Audio and PTs are aligned, phone boundaries are derived, and for each segment-phone combination it is determined how well they fit together, i.e. for each phone a TQE measure (a confidence measure) is determined, e.g. ranging from 0-100%, indicating how well the fit is, what the quality of the phone transcription is. The output of the TQE tool will consist of a TQE measure and the segment boundaries for each phone in the corpus. The tool will be useful for validating, obtaining, and selecting phone transcriptions, for detecting phone strings (e.g. words) with deviating pronunciation, and, in general, it can be usefully applied in all research in various (sub-)fields of humanities and language and speech technology (L&ST) in which audio and PTs are involved. Target Start Date: 01-01-2010 Target End Date: 01-07-2010 Type: Demonstrator Project
G,WAS going on? Putative regulatory function of GWAS-identified markers of susceptibility to acute appendicitis

Appendicitis affects 7-9% of Americans and is the most common diagnosis requiring hospitalization of both children and adults. Several etiologies of appendicitis have been hypothesized, but definitive mechanisms remain elusive – a critical review of the literature does not support a primary role of fecaliths or lymphoid hyperplasia, as is commonly believed. It is known that appendicitis has heritable components, and so we collaborated with 23andMe Inc., a personal genomics company, to identify genetic determinants of susceptibility to acute appendicitis. 23andMe performed a genome-wide association study (GWAS) of 18,773 appendectomy cases and 114,907 controls, and identified one locus with genome-wide significance. In addition, the GWAS identified eight highly significant SNPs that did not reach genome-wide significance. Most of the SNPs identified using this analysis fell outside of protein-coding genes, thus bioinformatic analysis using RegulomeDB was done to interrogate the SNPs’ putative regulatory capacity of nearby or distant genes, or proteins. This analysis identified 921 targets of putative regulatory elements in the same LD blocks as the four of nine lead SNPs identified in the GWAS and chosen for follow-up study. Of these, 299 targets were unique when targets from all four genomic regions were combined. These targets were organized according to the distance of their putatively egulatory SNP from the given lead SNP, and based on overlap of elements’ targets within one region with targets of elements within the rest of the genomic regions. Ultimately, the following list of 17 proteins was generated for priority in further studies: CEBPB, CTCF, EP300, EVI-1, FOS, FOXJ3, FOXP1, GATA1, HNF4A, JUN, MYC, NFKB, PPARG, RAD21, SPI1, STAT1, and STAT3. This list includes several proteins that directly interact with, or influence the expression of very specific inflammatory markers known to be strongly associated with appendicitis, including IL-8, IL-1B, and IL-6. This outcome supports the utility of RegulomeDB in the interpretation of GWAS-generated non-coding variants. This compiled resource and the ongoing parallel studies born of the appendectomy GWAS may help to elucidate the pathogenesis of acute appendicitis, thereby providing opportunities to improve the diagnosis, treatment, and prevention of this extremely common disease. The public health significance of appendicitis and its genetics are addressed, and a theoretical public health program that integrates the multiple factors involved in appendicitis etiology is proposed.
Treatment of delayed -onset muscle soreness: Is prevention the answer?

KEY POINTS: • Numerous strategies exist to ameliorate delayed-onset muscle soreness (DOMS) after strenuous activity, but a theoretically sound and consistent treatment has not been established. • Treatments showing promise for the relief of DOMS after exercise-induced damage include use of some non-steroidal anti-inflammatory drugs, compression, yoga training, and increases in light muscle activity. • For the athlete, preventing muscle damage through gradual adaptation to stressful exercise may be the best treatment strategy for DOMS.
Time domain analysis of distribution system harmonics. I. Development of power electronic simulator

The features of the power electronic simulator are described. It is shown how it can be applied to harmonic analysis of distribution system networks. The accuracy of the simulator for harmonic analysis is validated by comparison with other techniques for both nonresonant and resonant conditions. Converter and three-phase AC motor loads are given particular attention. <<ETX>>
Severe Toxicity of Clofarabine combined to Cyclophosphamide and Etoposide in two Children with Relapsed Acute Lymphoblastic Leukaemia (ALL)

Clofarabine use has been reported to be safe in previous studies. We report 2 cases of relapsed ALL in children, one of them occurring after bone marrow transplantation. The patients were treated with clofarabine 40 mg/m2, etoposide 100 mg/m2 and cyclophosphamide 440 g/m2. They developed severe toxicity leading to death, with multi-organ failure developing less than 10 days after chemotherapy Details of the patients' evolution are given. Severe adverse events of clofarabine in children seem not to be as rare as reported.
Exercise and insulin-dependent diabetes mellitus questionnaire : modifications required in diet and insulin administration for the active person with insulin-dependent diabetes

Regular physical exercise is beneficial for the person with insulin-dependent diabetes mellitus (IDDM). Participation in regular physical exercise, however, adds extra challenges that must be overcome in order to maintain acceptable metabolic control with each exercise session. Research in the area of diabetes and exercise has focused on the potential for exercise to improve overall metabolic control. As a result of this research, a wide range of recommendations for modifying diet and insulin for exercise in this population have been developed. There is a paucity of research on what steps an already active person with IDDM makes in order to maintain metabolic control before, during, and after exercise. The purpose of this study was to use a self-administered, mailed questionnaire to obtain information on the adjustments in insulin and diet currently used for exercise in active people with IDDM. A total of 137 members of the International Diabetes Athletes Association with IDDM qualified to participate in this study. The insulin administered prior to planned exercise was significantly lower than the amount of insulin administered on a non-exercise day. For subjects who injected their insulin, there was a significant decrease in the short acting insulin (p < 0.001), intermediate acting insulin (p = 0.006), long acting insulin (p = 0.042), and total insulin (p < 0.001) used prior to planned exercise. The insulin adjustments represented a 28.4 % reduction in short acting insulin, a 38.4 % reduction in intermediate acting insulin, a 9.7 % reduction in long acting insulin, and a 17.7 % reduction in total insulin injected. For subjects who used an insulin pump, there was a significant decrease in the basal insulin infused (p = 0.024), the bolus insulin administered (p < 0.001), and the total insulin (p < 0.001) used prior to planned exercise. The insulin
Patient Outcomes and Prognostic Factors

Study objective: To identify the prognostic factors for pneumothorax in patients in the ICU. Design: Retrospective cohort study. Setting: ICU at a university-based teaching hospital. Patients and methods: Sixty patients developed pneumothoraces in the ICU during a period of 36 months. Medical records relating to patients’ age, sex, underlying diseases, associated medical conditions, reasons for admission, acute physiology and chronic health evaluation (APACHE) II scores, procedures performed before the development of pneumothorax, occurrences of tension pneumothorax, duration of chest tube placement, chest tube removal, duration of ICU stay, and patient outcomes all were analyzed. A multivariate logistic regression model was applied with variables that were significantly associated with survival in the univariate analysis. The probabilities of chest tube removal were calculated using the Kaplan-Meier method. Results: Thirty-five patients (58%) had procedure-related pneumothoraces. The procedure that most commonly caused pneumothoraces was thoracentesis (n 19; 54%), followed by central vein/pulmonary artery catheterization (n 14; 40%) and bronchoscopy/transbronchial lung biopsy (n 8; 23%). A multivariate logistic regression analysis also showed that pneumothorax due to barotrauma (p 0.001), tension pneumothorax (p 0.0023), and concurrent septic shock (p 0.0476) were significantly and independently associated with death. The log-rank test revealed that the success rate of chest tube removal was higher in patients with procedurerelated pneumothoraces (p 0.0055). Conclusions: Patients with procedure-related pneumothoraces had better outcomes. Patients with pneumothoraces occurring in the ICU due to barotrauma, or a complicating tension pneumothoraces, carry a higher risk of mortality. (CHEST 2002; 122:678 – 683)
Advanced software engineering, expanding the frontiers of software technology : IFIP 19th World Computer Congress, First International Workshop on Advanced Software Engineering, August 25, 2006, Santiago, Chile

Software Architecture. - A Meshing Tool Product Line Architecture. - A Model for Capturing and Tracing Architectural Designs. - Multidimensional Catalogs for Systematic Exploration of Component-Based Design Spaces. - Software Modeling. - Practical Verification Strategy for Refinement Conditions in UML Models. - A cognitive model of user interaction as a guideline for designing novel interfaces. - An empirical evaluation for business process tools. - Integration Ontology for Distributed Database. - Software Development Process. - SSP: A Simple Software Process for Small-Size Software Development Projects. - A Method for Collaborative Requirements Elicitation and Decision-Supported Requirements Analysis. - Defining Security Requirements Through Misuse Actions. - Experiences in Software Development. - Experiences in Portable Mobile Application Development. - Adapting Aspect-Oriented Applications: A Trial Experience. - Building a 3D Meshing Framework Using Good Software Engineering Practices.
NDT_A_198434 1421..1426

Omar A Amin Saleh M Abouzeid Siham A Ali Bashir A Amin Khaled A Alswat 5 1Department of Orthopedic, Al Noor Specialist Hospital, Makkah, Saudi Arabia; 2Department of Rheumatology, Al Azhar University, Cairo, Egypt; 3Department of Neurology, Banha University, Banha, Egypt; 4Department of Medicine, Taif University, School of Medicine, Taif, Saudi Arabia; 5Department of Medicine and Endocrinology, Taif University School of Medicine, Taif, Saudi Arabia Objective: Fibromyalgia syndrome (FMS) is a chronic disorder associated with severe pain. According to the National Fibromyalgia Association, the prevalence of FMS is between 3% and 6% in the general population, with about 90% of the patients being women. The primary goal of this study was to evaluate the relationship between vitamin D and serotonin levels and FMS severity. Methods: Forty participants with fibromyalgia (mean age: 37.8±9.5 years) were included and had their medical history taken, a physical examination, and laboratory testing in the Rheumatology Department at Al-Ameen Hospital in Taif, Saudi Arabia. The revised Fibromyalgia Impact Questionnaire (FIQR) was used to determine the FMS severity. Results: The results showed that 42.5% of the patients were considered to have mild/ moderate fibromyalgia, with the remainder having severe/extreme fibromyalgia. The latter were more likely to have lower serotonin levels. The results showed a significant dosedependent negative relationship between the serotonin levels and FIQR scores (P=0.002). However, no significant correlations were found between the vitamin D levels and FIQR scores (P=0.112). Conclusion: The findings of this study show that the improved health of FMS patients is associated with normal serotonin levels.
Effects of cycocel on growth, some physiological traits and yield of wheat (Triticum aestivum L.) under salt stress

In order to investigate changes in sodium ion (Na+), potassium ion (K+), dry matter mobilization and grain filling period of wheat (Triticum aestivum L.) under salinity stress, a factorial experiment was conducted based on randomized complete block design with three replications. Factors were salinity at four levels [no-salt (S0) and salinity of 25 (S1), 50 (S2) and 75 (S3) mM NaCl, equivalent of 2.3, 4.61 and 6.92 dS m−1, respectively] and four cycocel levels [without cycocel (C0) and application of 400 (C1), 800 (C2) and 1200 (C3) mg L-1 cycocel)]. Results showed that salinity stress decreased grain yield, chlorophyll index, grain filling period, stomata conductance and relative water content in plant shoots. But grain filling rate and dry matter remobilization from shoots increased. Application of cycocel at C3 level led to the reduction of 36.36% and 5.75% in dry matter remobilization from shoot and stem, respectively. In the case of mineral content, Na+/K+ ratio was increased with increasing salinity level. At all salinity levels, cycocel application resulted in lower Na+ content and Na+/K+ ratio. Higher K+ accumulation in the cycocel treated plants, resulted in a low Na+/K+ ratio leading to their efficiency in salinity tolerance. It was concluded that cycocel can be a proper toolfor increasing wheat yield under salinity condition.
Homeobox gene expression in normal haemopoiesis and leukaemogenesis.

MLL (Mixed-Lineage or Mveloid-Lymphoid Leukaemia), the mammalian homologue of the Drosophila trithorax gene, is a gene located on chromosome band 1 lq23 that is frequently rearranged in myeloid and lymphoblastic leukaemias. The mechanism by which MLL rearrangements lead to leukaemia is still unknown. One potential mechanism by which MLL rearrangements give rise to leukaemia is by deregulation of its target genes. Therefore, the purpose of this project was to investigate the expression of MLL target genes in haematopoiesis and to determine if their deregulation is associated with leukaemogenesis. Two putative target genes of MLL were selected for this study: PITX2 (also known as ARPl <ALL-1/MLL responsive protein 1>, Rieg, Otlx or Brxl) and H0XA7. The bicoid-TQ\di\. Q6. homeobox gene PITX2 was initially identified as the causative gene for the autosomal dominant human disorder, Rieger syndrome. It is also involved in the formation of left-right asymmetry and anterior structures during embryogenesis. Recently, Pitx2 was isolated by differential display as a gene that is down-regulated in MLL knockout embryonic stem cells. To investigate if PITX2 is involved in haematopoiesis, the expression pattern in normal and leukaemic cells was studied by RT-PCR and northern blotting. The results indicate that PITX2 is expressed in normal haematopoietic cells but suggest that it is not regulated by MLL and is not deregulated in leukaemic cells. H0XA7 up-regulation is associated with a poor prognosis in patients with acute myeloid leukaemia. To study the potential role of H0XA7 in myeloid differentiation the U937 cell line was used. U937 cells are promonocytic cells that can be induced to differentiate into a more mature macrophage-like phenotype in vitro by addition of PMA. The Tet-Off system was used to overexpress H0XA7 during differentiation and markers of proliferation and differentiation were analysed. No differences in proliferation were observed. However, there was a marked reduction in the number of CD 1 lb-expressing cells and adherent cells. Both are markers of differentiation. The results suggest that de-regulation of H0XA7, but not PITX2, could contribute to a leukaemic phenotype.
Bio-engineering of neuromesodermal progenitors

Neuromesodermal progenitors (NMPs) are a cell population that has been pointed as responsible for generating both posterior neural precursors and mesoderm derivatives that will develop into the spinal cord. These progenitors function during embryonic gastrulation, when epiblast cells undergo differentiation to establish three germ layers (endoderm, mesoderm, and ectoderm) that will give rise to all tissues in the embryo. NMPs have been studied in vitro, using a protocol for threedimensional (3D) generation of cell aggregates, entitled gastruloids, through self-organization in presence of Wnt pathway agonists that activate polarized 3D elongation. However, this method has limitations, concerning efficiency and reproducibility of the process. In this work, I aimed at developing more robust methods to generate and propagate NMPs in culture, starting from mouse embryonic stem cells (mESCs). To achieve this aim, I employed a mechanical scaffold during in vitro gastruloid development, using poly(lactic-co-glycolic acid) (PLGA) fibers. To monitor the process, I used morphological approaches in which aggregates were counted and measured, while also doing fluorescence detection with Sox1::GFP cells and immunofluorescence with relevant molecular markers for NMPs. Results show an increase in successful gastruloid formation and elongation when PLGA was used, while also exhibiting a patterned cell growth with less variability, thus representing a more robust protocol than the original one where fibers were not used. Additionally, I found that neural tissue emerging in extending fiber-supported gastruloids are organized in a neural tube-like structure, showing hints of apicobasal epithelial polarity, suggesting that PLGA fibers provide adequate mechanical support for tissue organization.
Relationship of Causality Between Spot And Futures Markets of Borsa Istanbul Index 30 and Dow Jones Industrial Average

Futures markets are mainly used as a tool for price discovery and for risk management on the spot markets and enable diversification for international portfolio investments. With this study we aim (1) to investigate the causality relationship between futures markets and spot market and (2) to examine the causality relationship between futures markets and spot markets in different countries. We are interested in both the futures markets - spot market relations and the interactions between the markets at international level. For variables we used the the BIST30 spot index and BIST30 futures contract representing the Borsa Istanbul market and the Dow-Jones 30 index and Dow-Jones 30 futures contract, which are the most important indices representing the US markets. Daily closing price data for the period between 2nd January, 2009 and 18th June, 2018 were analyzed using correlation, unit root test, causality test and regression equations. The results of the study show that the futures markets continue their price discovery role for both the spot markets and futures markets and are influential on other futures and spot markets at international level. These findings are important for investors wanting to invest in Turkey and in similarly considered emerging market economies. It will help investors take informed decisions by providing them with a more efficient price estimations utilizing the futures markets.
The Supporting Healthy Marriage Evaluation: Early Impacts on Low-Income Families

The Supporting Healthy Marriage (SHM) evaluation was launched in 2003 to test the effectiveness of a skills-based relationship education program designed to help low-income married couples strengthen their relationships and, in turn, to support more stable and more nurturing home environments and more positive outcomes for parents and their children. The evaluation is led by MDRC, in collaboration with Abt Associates and other partners, and is sponsored by the Department of Health and Human Services. The SHM program is a voluntary, yearlong, relationship and marriage education program for lowincome, married couples who have children or are expecting a child. The program provides group workshops based on structured curricula; supplemental activities to build on workshop themes; and family support services to address participation barriers, connect families with other services, and reinforce curricular themes. The study’s rigorous random assignment design compares outcomes for families who are offered SHM’s services with outcomes for a similar group of families who are not offered SHM’s services but can access other services. This report presents estimated impacts on the program’s targeted outcomes about one year after couples entered the study.