Miracle-dz/UniFAR-FTUs huggingface dataset:
Differentiating haemostasis from thrombosis for therapeutic benefit

Summary The central role of platelets in the formation of the primary haemostatic plug as well as in the development of arterial thrombosis is well defined. In general, the molecular events underpinning these processes are broadly similar. Whilst it has long been known that disturbances in blood flow, changes in platelet reactivity and enhanced coagulation reactions facilitate pathological thrombus formation, the precise details underlying these events remain incompletely understood. Intravital microscopy studies have highlighted the dynamic and heterogeneous nature of thrombus development and demonstrated that there are considerable spatiotemporal differences in the activation states of platelets within a forming thrombus. In this review we will consider the factors regulating the activation state of platelets in a developing thrombus and discuss how specific prothrombotic factors may influence this process, leading to excessive thrombus propagation. We will also discuss some potentially novel therapeutic approaches that may reduce excess thrombus development whilst minimising bleeding risk.
Optimization Production Planning Using Fuzzy Goal Programming Techniques

In the past two decades, ideal planning has been used for the multiple criteria decision making problem solving.The issue is raised here is that how to do a program to achieve the best and most comprehensive program that it haswell run ability? Because of costly medical equipment production process, it should pay more attention toproduction planning. In this research, this was carried out in the company’s beta; we are looking to fulfill twoobjectives, reducing the cost of production, increase revenue leading to increased profits. For the realization ofthese goals, we use the method of fuzzy planning, according to studies, we use simple collective models andcollective weighted method. According to the existing information and problem variables and TIVARY model,we find that the model leads to production costs and increasing income. According to the results of the research, werealized that for the realization of the Beta purposes, we should use TIVARY collective method. This study hasexpanded the discussion of optimization production planning using fuzzy goal programming techniques. Goalprogramming was used in various issues such as decision making. The most important goal programmingrestrictions is unclear goals. Fuzzy goal programming provided, it investigate fuzzy purpose in unknown level.
The next generation textile antennas based on substrate integrated waveguide technology

Textile antennas for body-worn applications have some very specific requirements and needs. From an electrical engineer's point of view, good radiation characteristics and impedance matching to the active electronics are important. From the wearer's perspective, the antenna should be unobtrusively integrated into the clothing, and the smart textile comfortable to wear. New techniques offer the potential to fulfill these different needs. One new approach consists of applying metalized eyelets to implement substrate integrated waveguide technology on textile materials. This results in high-performance on-body antennas with excellent behavior in close proximity of the human body. Two realizations are discussed: a wideband design and a miniaturized half mode substrate integrated waveguide dual-band design. Both yield excellent free-space and on-body performance, and superb antenna-body isolation, automatically resulting in very robust characteristics when deployed on-body.
Intracellular mechanisms involved in the regulation of vascular smooth muscle tone.

Vascular smooth muscle contraction is thought to occur by a mechanism similar to that described for striated muscles, i.e., via a cross-bridge cycling--sliding filament mechanism. This symposium focused on Ca2+ signalling and the role of intracellular free Ca2+ concentration, [Ca2+]i, in regulating vascular tone: how contractile stimuli leading to an increase in [Ca2+]i trigger vasoconstriction and how relaxant signals reduce [Ca2+]i causing vasodilation. M.P. Walsh opened the symposium with an overview emphasizing the central role of myosin phosphorylation-dephosphorylation in the regulation of vascular tone and identifying recent developments concerning regulation of [Ca2+]i, Ca2+ sensitization and desensitization of the contractile response, Ca(2+)-independent protein kinase C induced contraction, and direct regulation of cross-bridge cycling by the thin filament associated proteins caldesmon and calponin. The remainder of the symposium focused on three specific areas related to the regulation of vascular tone: Ca2+ signalling in relation to smooth muscle structure, structure-function relations of myosin, and the role of cyclic GMP (cGMP) dependent protein kinase. G.J. Kargacin described how smooth muscle cells are structured and how second messenger signals such as Ca2+ might be modified or influenced by this structure. J. Kendrick-Jones then discussed the results of mutagenesis studies aimed at understanding how the myosin light chains, particularly the phosphorylatable (Ca(2+)-calmodulin dependent) regulatory light chains, control myosin. The vasorelaxant effects of signalling molecules such as beta-adrenergic agents and nitrovasodilators are mediated by cyclic nucleotide dependent protein kinases, leading principally to a reduction in [Ca2+]i. T.M. Lincoln described the roles of cyclic nucleotide dependent protein kinases, in particular cyclic GMP dependent protein kinase, in vasodilation.
Notice of Violation of IEEE Publication PrinciplesA 10Gb/s SiGe transimpedance amplifier using a pseudo-differential input stage and a modified Cherry-Hooper amplifier

A 10Gb/s inductor-free transimpedance amplifier was realized in a 0.2 μm SiGe process with f/sub T/=60GHz. The input stage uses a pseudo-differential cascoded common emitter architecture that achieves both low input noise and good supply and substrate rejection. The wideband operation is assured by using input bondwire inductive peaking in conjunction with feedback capacitive peaking. Low voltage operation was achieved by eliminating the inter-stage isolation emitter followers and minimizing the capacitive load at the high impedance nodes through emitter degeneration and cross-coupled Miller capacitance neutralization.
Face Recognition Based on WT, FastICA and RBF Neural Network

Face is a complex multidimensional visual model and it is difficult to develop a computational model for recognition. A novel approach is presented to face recognition in this paper, which uses wavelet transform (WT), fast independent component analysis (FastICA) and radial basis function (RBF) neural networks. Firstly, low frequency subband images are extracted from original face image by 2D wavelet transform. Secondly, for reducing computational cost and converges difficultly, improved FastICA is applied to extract features from the low frequency subband image. Then, the extracted features are classified through RBF neural networks. Lastly, the proposed algorithm is tested on the ORL face database and result shows that it has good performance both in terms of recognition accuracy and robustness.
Neural Phrase-based Machine Translation

In this paper, we propose Neural Phrase-based Machine Translation (NPMT). Our method explicitly models the phrase structures in output sequences through Sleep-WAke Networks (SWAN), a recently proposed segmentationbased sequence modeling method. To alleviate the monotonic alignment requirement of SWAN, we introduce a new layer to perform (soft) local reordering of input sequences. Our experiments show that NPMT achieves state-of-the-art results on IWSLT 2014 German-English translation task without using any attention mechanisms. We also observe that our method produces meaningful phrases in the output language.
Evaluation of the Effectiveness of the H.A.N.D.S. SM Program

The purpose of this project was to determine the effectiveness of the Helping Administer to the Needs of the Student with Diabetes in Schools (H.A.N.D.S. sm ) continuing education program in improving the level of experience and competence in performing services associated with diabetes care. This program is a live course for school nurses providing clinical information about diabetes management and their professional role in the care of students with diabetes. Pre- and post-surveys were administered via e-mail to assess their level of experience and competence in diabetes care. A total of 105 nurses completed both surveys and were included in the analysis. The changes between pre- and post-survey questions were assessed. The H.A. N.D. S. participants’ levels of experience and competence for each of the four categories of diabetes care improved significantly, and a greater number of nurses reported being able to perform the services independently and having the ability to teach others.
Discounts and Consumer Search Behavior: The Role of Framing

This paper studies the pure framing effect of price discounts, focusing on its impact on consumer search behavior. In a simple two-shop search experiment, we compare search behavior in base treatments (where both shops post net prices without discounts) to discount treatments (where either the first shop or the second shop posts gross prices with separate discount offers, keeping the net prices constant). Although the objective search problems are identical across treatments, subjects search less in discount frames, irrespective where the discount is offered. There is evidence showing that subjects only base their decisions on salient characteristics of the situation rather than on the objective price information.
Corpus Selection Approaches for Multilingual Parsing from Raw Text to Universal Dependencies

This paper describes UALing’s approach to the CoNLL 2017 UD Shared Task using corpus selection techniques to reduce training data size. The methodology is simple: we use similarity measures to select a corpus from available training data (even from multiple corpora for surprise languages) and use the resulting corpus to complete the parsing task. The training and parsing is done with the baseline UDPipe system (Straka et al., 2016). While our approach reduces the size of training data significantly, it retains performance within 0.5% of the baseline system. Due to the reduction in training data size, our system performs faster than the naïve, complete corpus method. Specifically, our system runs in less than 10 minutes, ranking it among the fastest entries for this task. Our system is available at https://github.com/CoNLL-UD-2017/UALING.
Increasing concurrent transmissions in CDMA ad hoc networks

In ad hoc networks successful transmission between two nodes are ensured by inhibiting transmitters around each receiver. The paper shows that this minimum separation (Critical Radius) can be reduced by employing spread spectrum (CDMA) at the physical layer. Analytical expressions of critical radius for different multiple access schemes are compared. The improvement in capacity at the cost of bandwidth expansion for an ad hoc network in which nodes are uniformly distributed is presented. This trade off is shown to make sense as the number of nodes increases. A system design is also developed for CDMA based ad hoc networks, combining CSMA and CDMA to provide universal spatial reuse and high robustness to packet collisions.
Stimulation of the Amyloidogenic Pathway by Cytoplasmic Superoxide Radicals in an Alzheimer's Disease Mouse Model

Oxidative stress is involved in the pathogenesis of neurodegeneration. Amyloid β (Aβ) oligomer as an intermediate of aggregates causes memory loss in Alzheimer's disease (AD). We have suggested that oxidative stress plays an important role in Aβ oligomerization and cognitive impairment using a human amyloid precursor protein (hAPP) transgenic AD mice lacking cytoplasmic superoxide dismutase (hAPP/Sod1 −/−). Recently, clinical trials revealed inhibitors of Aβ production from hAPP as promising therapeutics, but the relationship between oxidative stress and Aβ metabolism remains unclear. Here we found that Sod1 deficiency enhanced β-cleavage of hAPP, suggesting that it increased Aβ production in hAPP/Sod1 −/− mice. In contrast, Aβ degradation did not decrease in hAPP/Sod1 −/− as compared with hAPP/Sod1 +/+ mice. Furthermore, we successfully detected in situ superoxide radicals associated with increased protein carbonylation in hAPP/Sod1 −/−. These results suggest that cytoplasmic oxidative stress is involved in Aβ production as well as aggregation during AD progression.
Three-Way Parallel-Coupled Microstrip Power Divider With Ultrawideband Performance and Equal-Power Outputs

A compact equal-power three-way divider with ultrawideband performance is presented. The proposed device utilizes simple, three parallel-coupled microstrip lines. In order to enable the use of practical gaps between the tightly coupled lines, slotted ground plane and lumped capacitors, which are connected symmetrically between the two sidelines and the centerline, are utilized. The conformal mapping technique is employed to find the dimensions of the device. The simulated and measured output power, return loss, and isolation show that the proposed divider operates well across the frequency band from 4 to 11 GHz.
FIGfams: yet another set of protein families

We present FIGfams, a new collection of over 100 000 protein families that are the product of manual curation and close strain comparison. Using the Subsystem approach the manual curation is carried out, ensuring a previously unattained degree of throughput and consistency. FIGfams are based on over 950 000 manually annotated proteins and across many hundred Bacteria and Archaea. Associated with each FIGfam is a two-tiered, rapid, accurate decision procedure to determine family membership for new proteins. FIGfams are freely available under an open source license. These can be downloaded at ftp://ftp.theseed. org/FIGfams/. The web site for FIGfams is http://www.theseed. org/wiki/FIGfams/
Soluble Spiroperidol Binding Factors from Bovine Caudate Nucleus

Abstract: Several properties of soluble spiroperidol binding factors separated from bovine caudate nucleus have been investigated by a previously unreported procedure. Data consistent with high particle weight and rapid binding equilibration are reported for high‐affinity (+)butaclamol‐sensitive components of a digitonin extract. A slower sedimenting component is found that also exhibits high affinity for spiroperidol but is not sensitive to (+)butaclamol. Centrifugation of a caudate nucleus homogenate yields a supernatant that appears to contain a component that exhibits spiroperidol binding that is more sensitive to displacement by (‐) than by (+)butaclamol. The procedure used effects rapid separation of bound from unbound tritiated ligand on short columns of Sephadex G‐15 followed by extrusion and sectioning of the Sephadex. The radioactivity remaining with each section is determined. The procedure is very rapid; the addition of active phases or the changing of the ionic environment, which may disturb the equilibrium, is avoided; and recovery of the protein free of bound ligand is easily affected.
Effect of Escherichia coli infection of the bovine uterus from the whole animal to the cell.

Following parturition, contamination of the uterine lumen by bacteria is ubiquitous, and uterine health is impaired in cattle because infection persists in 10% to 15% of animals as endometritis. Endometritis causes infertility for the duration of infection, and subfertility persists even after apparent successful resolution of the disease. Escherichia coli is the pathogenic bacterium most frequently isolated from the post partum uterus, and is associated with increased concentrations of peripheral plasma acute phase proteins and fetid vaginal mucus. The presence of E. coli is also associated with slower growth of the first post partum dominant follicle and perturbed oestradiol secretion. Furthermore, in animals that ovulate the first dominant follicle, the corpus luteum is smaller and secretes less progesterone. The endotoxin lipopolysaccharide (LPS), which is released from E.coli, can pass from the uterine lumen to the peripheral circulation and LPS concentrations are increased in cows with uterine infection. Infusion of E. coli LPS into the uterine lumen suppresses the pre-ovulatory luteinising hormone surge and disrupts ovulation in heifers. In vitro, endometrial explants produce prostaglandins in response to LPS. Addition of LPS or E. coli to stromal or epithelial cells increases cyclooxygenase-2 mRNA expression, and stimulates the production of prostaglandin E2 and prostaglandin F2α . Furthermore, uterine and ovarian cells express mRNA of the molecules required for recognition of LPS, Toll-like receptor-4 and CD14. In summary, E. coli is a common cause of infertility involving the perturbation of the hypothalamus, pituitary and ovary in dairy cows.
Nonlinear synchronization in open flows

The selection criteria governing finite-amplitude synchronized oscillating states are discussed for model systems and real wake flows in a domain of infinite streamwise extent. Two types of nonlinear global modes are possible: hat modes with overall smoothly varying amplitude and elephant modes with a sharp front. The vortex street in wake flows is of elephant type, as observed in direct numerical simulations of a real spatially developing wake. Furthermore, the elephant frequency selection criterion is in excellent agreement with the numerically determined vortex shedding frequency.
The added risk of opioid problem use among treatment-seeking youth with marijuana and/or alcohol problem use.

OBJECTIVES To determine the added risk of opioid problem use (OPU) in youth with marijuana/alcohol problem use (MAPU). METHODS A total of 475 youth (ages 14-21 years) with OPU + MAPU were compared to a weighted sample of 475 youth with MAPU only (i.e. no OPU) before and after propensity score matching on gender, age, race, level of care and weekly use of marijuana/alcohol. Youth were recruited from 88 drug treatment sites participating in eight Center for Substance Abuse Treatment-funded grants. At treatment intake, participants were administered the Global Appraisal of Individual Need to elicit information on demographic, social, substance, mental health, human immunodeficiency virus (HIV), physical and legal characteristics. Odds ratios with confidence intervals were calculated. RESULTS The added risk of OPU among MAPU youth was associated with greater comorbidity; higher rates of psychiatric symptoms and trauma/victimization; greater needle use and sex-related HIV risk behaviours; and greater physical distress. The OPU + MAPU group was less likely to be African American or other race and more likely to be aged 15-17 years, Caucasian; report weekly drug use at home and among peers; engage in illegal behaviors and be confined longer; have greater substance abuse severity and polydrug use; and use mental health and substance abuse treatment services. CONCLUSIONS These findings expand upon the existing literature and highlight the substantial incremental risk of OPU on multiple comorbid areas among treatment-seeking youth. Further evaluation is needed to assess their outcomes following standard drug treatment and to evaluate specialized interventions for this subgroup of severely impaired youth.
"Style", un mot et des discours

Ce livre voudrait faire le point sur nos usages contemporains du mot style, tant en emploi populaire, spontane ou travaille, qu'en emploi savant specialise. Le corpus est d'abord la langue francaise du debut du XXIe siecle, telle qu'on la pratique, la parle et l'ecrit dans les livres, a la television ou sur Internet. L'objet d'etude est l'usage general d'un mot, d'un mot-repere de notre culture, a l'entrecroisement de pratiques discursives dont la diversite et la dispersion font sens et valeur entrecroisement que l'on pensait, jadis, comme le lieu meme de l'ideologie. Le mot style est envisage dans quelques-unes des scenographies sociales les plus riches, soit les plus sollicitees, quantitativement, par les sujets parlants du debut du XXIe siecle : discours scolaire, discours universitaire, discours mediatique, discours commercial, discours politique.
Multi-Parameter Sensing Using a Fiber Bragg Grating Inscribed in Dual-Mode Fiber

We propose a method for simultaneous measurement of strain, temperature, and surrounding refractive index (SRI) using a fiber Bragg grating (FBG) inscribed in dual-mode fiber by femtosecond laser. This FBG not only possesses two Bragg resonances corresponding to LP<sub>01</sub> and LP<sub>11</sub> modes, respectively, but also shows many strong cladding mode resonances, which are sensitive to SRI. Due to the different responses, the strain, temperature, and SRI can be discriminated simultaneously by measuring the two Bragg resonance wavelengths and the normalized area of cladding mode resonances. The estimated resolutions of this FBG in measuring strain, temperature, and SRI are <inline-formula> <tex-math notation="LaTeX">$\pm 6.3~\mu \varepsilon $ </tex-math></inline-formula>, ±0.8 °C, and ±2.7 <inline-formula> <tex-math notation="LaTeX">$\times 10^{-5}$ </tex-math></inline-formula> RIU, respectively.
First-Time Inversion Ankle Ligament Trauma

Background Inversion ankle trauma is disabling, yet little is known regarding the incidence rate of first-time ankle sprains and how it is influenced by factors including sex, level of competition, and sport. Hypothesis The incidence rates of first-time ankle ligament sprains are influenced by sex, level of competition (high school vs college), and type of sports participation (basketball, soccer, lacrosse, and field hockey). Study Design Cohort study; Level of evidence, 2. Methods Between 1999 and 2003, high school and college athletes were evaluated before participation in their sports. Subjects were included in the study if they had not experienced a prior ankle or lower extremity injury and were then followed during participation in soccer, basketball, lacrosse, or field hockey to document their days of exposure to sport and injuries sustained. The relative risk associated with sex, level of competition, and sport was estimated by Cox regression. Results A total of 901 athletes had 50 680 person-days of exposure to sports, and 43 (4.8%) had an inversion injury that produced an ankle ligament sprain. Overall, the injury incidence rate was 0.85 sprains per 1000 person-days of exposure to sport. There were 0.68 and 0.97 ankle sprains per 1000 person-days of exposure to sport for the men and women, respectively. Although the risk of suffering an ankle sprain was higher for women than for men (relative risk, 1.51), the difference was not statistically significant (P=. 21) and was owing to the increased risk in female basketball athletes compared to male basketball athletes (relative risk, 4.11; P=. 045). Risk of injury was similar for the high school athletes in comparison to the college athletes (relative risk, 1.16). For the men, there was no difference in the risk of suffering an ankle sprain between the sports of basketball, soccer, and lacrosse, whereas for the women, the risk of suffering an ankle sprain was significantly greater during participation in basketball compared to lacrosse. Conclusion In this study of first-time ankle sprains, for most sports, the incidence rate of inversion injury is less than 1 per 1000 days of exposure to sport, a value lower than previously reported. Among female athletes, ankle injury is associated with type of sport. Risk is highest for female basketball athletes, who are at significantly greater risk than male basketball athletes and female lacrosse athletes. The risk of first-time ankle injury is similar for high school and college-level athletes.