Miracle-dz/UniFAR-FTUs huggingface dataset:
Research on Improving Dynamic Business Procesess in HIS

Dynamic patient treatment processes are usually human-centric and often unique. So if you want to model the different processes of the patient treatment, system must be capable to dynamically change process components, for example activities and business rules at runtime. The problem of process dynamics has been actively investigated over the last few years but there are still problems to be solved. This paper presents related literature analysis of the dynamic business processes. The analysis shows that there is no unified view of dynamic business processes the formulated problems and proposed approaches to implement dynamic processes are very different. The analysed approaches cannot fully implement dynamic processes because they do not fully confirm needed dynamic process requirements. In the paper new dynamic process model is presented and realised. Dynamic patient treatment process model was developed and realised.
Truncated Circular Cone Slot Antenna Array That Radiates a Circularly Polarized Conical Beam

A truncated circular cone slot array antenna that radiates a circularly polarized (CP) conical beam is presented. The direction into which the conical beam radiates depends mainly on the tilt angle of the outer conductor as well as the proper arrangement of the positions of its two slot arrays. The CP property is realized by introducing quasi-perpendicular slots that are cut into the outer conductor of a truncated circular cone. To illustrate the performance characteristics of this CP conical beam antenna, the tilt angle is set to 45° and the beam angle is pointed at 45° from boresight within the operating band. A prototype was fabricated and tested. The measured results demonstrate that its −10 dB impedance bandwidth ($\vert S_{{11}}{\rm{\vert \,< \,-10}}$ dB) is 720 MHz, from 5.05 to 5.77 GHz; and its 3 dB axial-ratio (AR) bandwidth is 500 MHz, from 5.5 to 6.0 GHz. Its realized gain over this AR bandwidth ranges from 4.84 to 5.8 dB. The designed beam direction can be easily changed to meet specific application requirements. Moreover, it can be readily reconfigured to be a conformal antenna mounted on the top of a high-speed mobile platform.
Flexible Deep Neural Network Processing

The recent success of Deep Neural Networks (DNNs) has drastically improved the state of the art for many application domains. While achieving high accuracy performance, deploying state-of-the-art DNNs is a challenge since they typically require billions of expensive arithmetic computations. In addition, DNNs are typically deployed in ensemble to boost accuracy performance, which further exacerbates the system requirements. This computational overhead is an issue for many platforms, e.g. data centers and embedded systems, with tight latency and energy budgets. In this article, we introduce flexible DNNs ensemble processing technique, which achieves large reduction in average inference latency while incurring small to negligible accuracy drop. Our technique is flexible in that it allows for dynamic adaptation between quality of results (QoR) and execution runtime. We demonstrate the effectiveness of the technique on AlexNet and ResNet-50 using the ImageNet dataset. This technique can also easily handle other types of networks.
Mechanisms leading to musculoskeletal disorders in dentistry.

BACKGROUND The authors reviewed the implications of prolonged, seated working postures on dental operator health and the potential development of musculoskeletal disorders, or MSDs. TYPES OF STUDIES REVIEWED The authors reviewed studies to assess the mechanisms associated with the development of musculoskeletal pain and MSDs among dental operators. Some studies investigated work duration, operator positioning and the physiological effects of various static sitting postures. Others explored the relationships between prolonged muscle contraction and muscle imbalances, as related to the development of pain and MSDs. RESULTS This review advances the idea that the causes of musculoskeletal pain and disorders common to dental operators are multifactorial. Physiological changes that accompany these disorders can be related to practices used by today's operators-primarily being seated for prolonged periods. Studies associated such postures with increased disk pressures and spinal hypomobility, which are factors that may lead to degenerative changes within the lumbar spine and low back pain or injury. There is a relationship shown between prolonged, static (motionless) muscle contractions and muscle ischemia or necrosis. Weak postural muscles of the trunk and shoulder may lead to poor operator posture. As muscles adapt by lengthening or shortening to accommodate these postures, a muscle imbalance may result, leading to structural damage and pain. CLINICAL IMPLICATIONS A significant number of today's dental operators experience musculoskeletal pain and are at risk of developing serious MSDs. A thorough understanding of the underlying physiological mechanisms leading to these problems is necessary to develop and implement a comprehensive approach to minimize the risks of a work-related injury.
Independently Tunable/Controllable Differential Dual-Band Bandpass Filters Using Element-Loaded Stepped-Impedance Resonators

This paper presents a new approach for designing differential bandpass filter (BPF) with independently tunable/controllable dual passbands using the element-loaded stepped-impedance resonators (SIRs). The frequency-agile ability of the fundamental and third-harmonic resonant frequencies (<inline-formula> <tex-math notation="LaTeX">$f_{1}$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$f_{3})$ </tex-math></inline-formula> of the element-loaded SIR against the value of the loaded element under different loading positions on the SIR is theoretically analyzed. It can be found that there must be a position that could be utilized to load element to realize the independent control of <inline-formula> <tex-math notation="LaTeX">$f_{1}$ </tex-math></inline-formula> without affecting <inline-formula> <tex-math notation="LaTeX">$f_{3}$ </tex-math></inline-formula>. This feature is successfully applicable to design independently tunable differential dual-band BPF when the loaded elements are tunable capacitors. Furthermore, by making the loaded elements to be shunt stubs, a new coupling path can be constructed for <inline-formula> <tex-math notation="LaTeX">$f_{1}$ </tex-math></inline-formula>, and then the coupling coefficients for the two bands can be separately varied. Both the operational frequencies and bandwidths of the two bands can be separately adjusted. As a result, the traditional design procedure for the differential dual-band BPF can be simplified significantly. For demonstration, two examples are designed, implemented, and measured, and their simulation and measured results are presented, showing good accordance.
The Risk of Foraminal Violation and Nerve Root Impingement After Anterior Placement of Lumbar Interbody Fusion Cages

Study Design. Three groups of six embalmed cadaver spines underwent placement of lumbar interbody fusion cages centered either at midline, 10% lateral of midline, or 20% lateral of midline. The spines were evaluated for evidence of neuroforamen violation or nerve root impingement. Objectives. To determine the potential for foraminal violation or nerve root impingement after correct placement and lateral misplacement of lumbar interbody fusion cages. Summary of Background Data. Radicular symptoms after anterior cage placement have raised some concern about the potential for inadvertent device-related foraminal violation not adequately appreciated by intraoperative fluoroscopy. Methods. Preoperative computed tomography scanning and plain radiography was used to measure endplate dimensions at L4–L5 and to template the appropriately sized interbody fusion cages. The cadaveric specimens were randomly divided into three groups of six (Groups I–III) and instrumented at L4–L5 either at midline (I) or 10% (II) or 20% (III) lateral of midline. Postoperative computed tomography and plain radiography was evaluated for evidence of neuroforamen violation, followed by dissection of the specimens. Results. Foraminal violation occurred in one of six spines in group II (10% off midline) and in three of six spines in group III (20% off midline). Two of the three cadavers in group III with foraminal violation also were noted to have nerve root abutment on computed tomography scans and spinal dissection. Conclusions. Excessive lateral placement of lumbar interbody fusion cages may result in foraminal violation and possible nerve encroachment. The “safe zone” for centering the cages extends approximately 5 mm on either side of midline.
Drug-resistant Mycobacterium tuberculosis strains isolated at an AIDS reference center general hospital in Rio de Janeiro *

Results: Twenty per cent (33/165) were resistant to at least one drug; 13% (12/165) to isoniazid; 3.64% (6/165) to rifampin and 3.64% (6/165) to both. Among HIV seropositive subjects (52/165); 28.85% (15/52) were resistant to at least one drug. Acquired resistance occurred in 15.79% of 19 patients that mentioned previous antiTB treatment. Association statistically significant was found with non cavitation on X-ray in bivariate analyses (P=0.05). Eighty four patients refereed no previous treatment (NPT). Resistance to 1 or more drugs was found in 28.57% (24/84) of NPT patients. Association statistically significant with initial resistance was found with health care workers (P=0.004), unemployment (P=0.03), and diarrhea (P=0.01) in bivariate analyses. On multivariate analyses, health care workers (P=0.002) remained significantly associated with initial resistance.
Entrepreneurial Intentions in Selected Southeast European Countries

Entrepreneurship has an increasingly important role in economic growth and development in both developed and underdeveloped countries. Also, various forms of entrepreneurial behavior are important in promoting economic and social development. Thus, it is not surprising that entrepreneurship and entrepreneurial activity have received a significant attention from both academics and policy makers. It is important for both groups to better understand the various factors that affect and stimulate entrepreneurial behavior. Previous research has shown that entrepreneurial intentions of individuals represent effective and strong explanatory factor that predicts quite well their future entrepreneurial behavior. Also, entrepreneurial intentions are crucial to the entrepreneurial process as an important first step in a series of actions that leads to the creation of entrepreneurial project. Although there are different theoretical models of entrepreneurial intentions in the extant literature, they actually contain conceptually related elements and offer quite comparable interpretations of entrepreneurial intentions. In order to explore entrepreneurial intentions and their antecedents in South-East European context we have conducted a paper-and-pencil self-administered survey among students of economics and business in four South-East European countries, namely: Bosnia and Herzegovina, Croatia, Macedonia and Serbia. The sample consisted of 1200 respondents, 300 of respondents from each country included in study. The highly structured questionnaire with set of items derived from the literature and Likert-type scale were used as data collection instrument. The following scales were included in the questionnaire: locus of control, risk taking propensity, perceived barriers, perceived support factors, personal attitude towards entrepreneurship, perceived behavioral control, subjective norm and entrepreneurial intention (Lumpkin, 1985; Luthje, Franke, 2003; Linan, Chen, 2009). Collected data were analyzed with multiple regression technique in order to explore the effects of various antecedents on entrepreneurial intention in the context of South-East European countries. The results indicate that personal attitude towards entrepreneurship, perceived behavioral control and subjective norm positively and significantly affect entrepreneurial intent. Respondents from Bosnia and Herzegovina exhibit higher levels of entrepreneurial intent compared to other observed countries. The findings of our research provide better understanding of entrepreneurial intentions and their antecedents in the specific post-transition context of South-East European countries. Theoretical and policy implications of research findings are discussed in the paper.
A simple and rapid evaluation of methemoglobin toxicity of 8-aminoquinolines and related compounds.

Methemoglobin, a toxic ferric form of hemoglobin, is continuously formed in normal erythrocytes, but during abnormal situations in situ, the level is enhanced. 8-Amino-quinolines and related compounds are causative agents for methemoglobin formation. Employing oxyhemoglobin, methemoglobin toxicity was about six times higher with primaquine compared to CDRI Compound 80/53 at 10(-9) M concentration. Methemoglobin reductase activity was also completely inhibited by primaquine, whereas 24% inhibition was noted in the case of 80/53 at the same concentrations. Mastomys, a rodent animal model, was found to be equally good for comparative evaluation of methemoglobin toxicity. Further, with the use of primaquine transdermal tape on the Mastomys model, a rise in methemoglobin occurred with increase in time. In conclusion, the study presents simple, economical, less time-consuming methods for the evaluation of methemoglobin toxicity, in vitro and in vivo, without employing the conventional Beagle dog model.
PATTERNS OF POSTZYGOTIC ISOLATION IN LEPIDOPTERA

Abstract I present patterns characterizing the evolution of intrinsic postzygotic isolation in Lepidoptera by analyzing data from the literature on genetic distance, strength of hybrid sterility and inviability, biogeography, and natural hybridization. Using genetic distance as a proxy for time, I investigate the time-course of the evolution of postzygotic isolation and the waiting times to particular hybrid fitness problems. The results show that postzygotic isolation increases gradually as species diverge, but that hybrid sterility evolves faster than hybrid inviability. The overwhelming preponderance of female-specific hybrid problems in Lepidoptera shows that Haldane's rule (the preferential sterility or inviability of the heterogametic sex) is well obeyed. Together the rates and patterns characterizing the accumulation of postzygotic isolation allow several tests of the composite theory of Haldane's rule. Interestingly, comparing these data with those from Drosophila reveals that Haldane's rule for sterility evolves as fast (if not faster) in Lepidoptera. Finally, I show that a substantial fraction of sympatric species hybridizes in nature and that the majority of these suffer some level of hybrid sterility or inviability.
Central nicotinic acetylcholine receptor involved in Ca2+‐calmodulin‐endothelial nitric oxide synthase pathway modulated hypotensive effects

BACKGROUND AND PURPOSE Recent evidence has suggested that nicotine decreases blood pressure (BP) and heart rate (HR) in the nucleus tractus solitarii (NTS), indicating that nicotinic acetylcholine receptors (nAChRs) play an important role in BP control in the NTS. However, the signalling mechanisms involved in nAChR‐mediated depressor effects in the NTS are unclear. Hence, the aim of this study was to investigate these signalling mechanisms.
Very High Frequency of the Polymorphism for the Insulin Receptor Substrate 1 (IRS-1) at Codon 972 (Glycine972Arginine) in Southern Italian Women with Polycystic Ovary Syndrome

A major component of the polycystic ovary syndrome (PCOS) is the insulin resistance. Only a few studies have evaluated the IRS-1 polymorphism at codon 972, sometimes in the absence of a control group, and with great variability in frequency (0-23% in PCOS vs. 0-17% in controls), and with no unequivocal relationships between the polymorphism and clinical or biochemical indexes. The aim of the work was to evaluate the frequency of the IRS-1 polymorphism at codon 972 in PCOS, and correlate it to clinical and biochemical indexes. We assessed the rs 1801278 polymorphic variant in the IRS-1 gene (Gly972Gly=wild-type; Gly972Arg=heterozygosity; Arg972Arg=homozygosity) in genomic DNA by restriction fragment length polymorphism. The study was conducted at an academic medical center with the participation of 65 women with PCOS and 27 age-matched healthy women (controls). Compared to controls, Gly972Arg was very frequent in PCOS (77% vs. 18%, p<0.0001); one PCOS woman was homozygous. Compared to wild-type PCOS, heterozygous PCOS women had only three significantly different indexes: higher fasting insulin, insulin resistance index, and lower 120 min OGTT glucose. Moreover, in the correlation analysis between any two clinical or biochemical variables, the Pearson's correlation coefficients were frequently of different magnitude in heterozygous PCOS versus wild-type PCOS. Overall, heterozygous PCOS had a greater number of statistically significant relationships between different clinical, metabolic and hormonal indexes: 44 direct and 9 inverse versus 6 and 3, respectively. The IRS-1 Gly972Arg has the highest frequency reported world-wide for PCOS women. This variant is associated with insulin resistance and higher fasting insulin in PCOS women.
Photoplethysmogram signal quality estimation using repeated Gaussian filters and cross-correlation

Pulse oximeters are monitors that noninvasively measure heart rate and blood oxygen saturation (SpO2). Unfortunately, pulse oximetry is prone to artifacts which negatively impact the accuracy of the measurement and can cause a significant number of false alarms. We have developed an algorithm to segment pulse oximetry signals into pulses and estimate the signal quality in real time. The algorithm iteratively calculates a signal quality index (SQI) ranging from 0 to 100. In the presence of artifacts and irregular signal morphology, the algorithm outputs a low SQI number. The pulse segmentation algorithm uses the derivative of the signal to find pulse slopes and an adaptive set of repeated Gaussian filters to select the correct slopes. Cross-correlation of consecutive pulse segments is used to estimate signal quality. Experimental results using two different benchmark data sets showed a good pulse detection rate with a sensitivity of 96.21% and a positive predictive value of 99.22%, which was equivalent to the available reference algorithm. The novel SQI algorithm was effective and produced significantly lower SQI values in the presence of artifacts compared to SQI values during clean signals. The SQI algorithm may help to guide untrained pulse oximeter users and also help in the design of advanced algorithms for generating smart alarms.
Central and peripheral opioid modulation of gastric relaxation induced by feeding in dogs.

The influence of i.v. vs. i.c. v. administration of [( D-Ala2, MetPhe4, Gly-ol5]enkephalin (DAMGO) and morphine), kappa U 50488 and ethylketocyclazocine and delta ([D-Pen2, D-Pen5]enkephalin (DPDPE)] opioid agonists on gastric relaxation induced by a standard meal was evaluated in conscious dogs with strain-gauge transducers implanted on the gastric fundus and antrum. Under control conditions, the amplitude of the gastric relaxation in response to feeding was 2.46 +/- 0.23 g. Given i.v. 10 min before feeding, both U 50488 (10 micrograms/kg) and ethylketocyclazocine (10 micrograms/kg) significantly (P less than .01) reduced the amplitude of the gastric relaxation by 57 and 68%, respectively, whereas DAMGO and morphine (10 micrograms/kg i.v.) increased markedly the response to feeding by 67 and 51%, respectively. In contrast, DPDPE had no effect on the gastric relaxation induced by feeding. Previous administration of naloxone (0.3 mg/kg i.v.) or MR 2266 (0.3 mg/kg i.v.) blocked the effect of U 50488 on gastric relaxation with no effect per se on the amplitude of response; naloxone also blocked the increase in gastric relaxation induced by DAMGO. When administered i.c. v. (0.1 microgram/kg) DAMGO induced a significant (P less than .05) increase in the amplitude of gastric relaxation whereas U 50488 and DPDPE (0.1 and 1 microgram/kg i.c.v.) had no effect. The effect of i.c. v. DAMGO on gastric relaxation was unaffected by a previous i.v. administration of SR 58002C (1 mg/kg). Truncal vagotomy blocked the increase in gastric relaxation induced by DAMGO (10 micrograms/kg i.v.), but did not change the effect of U 50488 (10 micrograms/kg i.v.) on gastric relaxation. (ABSTRACT TRUNCATED AT 250 WORDS)
The Role of the Family in Genetic Testing: Theoretical Perspectives, Current Knowledge, and Future Directions

This article addresses conceptual challenges and theoretical approaches for examining the role of the family in responding and adapting to genetic testing for inherited conditions. Using a family systems perspective, family-based constructs that are relevant to genetic testing may be organized into three domains: family communication, organization and structure of family relationships, and health-related cognitions and beliefs shared within families. Empirical findings are presented from key content areas in family-based genetics research, including family communication, how genetic testing affects family relationships, psychological responses to genetic testing in the family context, and family-based influences on health decisions. Future research should explore decision making about genetic testing or behavior change specifically within the context of the family system and should identify family-based determinants of genetic testing outcomes.
Dynamics and modulation of human immunodeficiency virus type 1 transcripts in vitro and in vivo

The dynamics of human immunodeficiency virus type 1 (HIV-1) transcription was analyzed in vitro and in vivo by using a specific molecular approach which allows accurate quantitation of the different classes of viral mRNAs. Unspliced (US) and multiply spliced (MS) HIV-1 transcripts were assayed by competitive reverse transcription (cRT)-PCR, using a single competitor RNA bearing in tandem internally deleted sequences of both template species. Acute HIV-1 infection of primary peripheral blood mononuclear cells (PBMCs), monocytes/macrophages cells, and the A3.01 T-lymphocyte-derived cell line was studied; both classes of HIV-1 mRNAs increased exponentially (r2 > 0.98) at days 1 to 3 and 1 to 4 postinfection in HIV(IIIB)-infected A3.01 cells and PBMCs, respectively, whereas monocytes/macrophages infected with monocytotropic HIV(BaL) exhibited a linear (r2 = 0.81 to 0.94) accumulation of US and MS transcripts. Following induction of chronically infected ACH-2 cells, MS transcripts increased 2 h postinduction and peaked at 5 h (doubling time, 58 min), while at 24 h, US mRNAs increased 3,053-fold compared with basal time (doubling time, 137 min). To address the biopathological significance of HIV-1 expression pattern during infection progression, pilot cross-sectional and longitudinal analyses were carried out with samples from untreated and treated HIV-1-infected patients. In almost all untreated (recently infected, long-term nonprogressor, and progressor) patients, MS transcript levels followed the general trend of systemic HIV-1 activity. In patients under treatment with powerful antiretroviral compounds, viral MS transcripts rapidly fell to undetectable levels, indicating that in vivo, levels of MS mRNAs in PBMCs are closely associated with the number of newly infected cells and suggesting a new role for the quantitative analysis of HIV-1 transcription in infected patients.