Miracle-dz/UniFAR-FTUs huggingface dataset:
JRC Insights - Social Policy Innovation Series - The role of the Social Economy in promoting Social Investment

Social enterprises play an important role in tackling societal challenges. Their numbers have grown significantly over recent years, becoming a strong engine of social innovation in the EU. This trend is confirmed by results of the JRC-led IESI project, which supports the implementation of the EU Social Investment Package through the analysis of ICT-Enabled Social Innovation initiatives in Member States. This issue of the â€˜JRC Insightsâ€™ presents results from the study of these initiatives, assessed against the three main objectives of the Social Investment Package: implementing active inclusion strategies, investing in individuals throughout their lives and modernizing social protection systems. Evidence gathered shows that social enterprises are crucial in realising these policy goals. Their capacity to identify emerging or unmet needs, engage stakeholders and turn their governance model into a sustainable production process makes them particularly apt to contribute to social investment approaches. Social enterprises are the most innovative forms of social economy and their action tends to be flexible and responsive, thanks to their capacity to involve users and understand their needs. Their governance structures, their roots in local communities, and the fact that they are often multi-stakeholder partnerships contribute to greater social innovation. Nevertheless, more comprehensive socio-economic impact evaluations are required to understand what initiatives could and should be fostered and scaled-up.
Does It Pay to Pay Attention?

We employ a novel brokerage account dataset to investigate the relation between individual investor attention and performance. In addition to portfolio holdings and trades, we observe when investors log-in to their trading account, what information they look at, and how much time they spend processing such information. We show that attention is positively related to investment performance – both at the portfolio return level as well as the individual trades level – and provide evidence that the superior performance of high-attention investors arises because they behave as momentum traders that purchase stocks early in the momentum cycle, several months before reversal sets in. We also show that paying attention is particularly profitable when trading stocks with high market capitalization, trading volume, volatility, number of analysts, dispersion of analyst forecasts, and news – indicating that it is for the stocks with high uncertainty, but for which a lot of public information is available, that it pays to pay attention. Finally, we find that account holders with higher invested wealth and higher exposure to small capitalization stocks, growth stocks, momentum stocks, and the overall market, are more attentive; that males pay more attention than females; and that attention is an increasing function of investors’ age.
Socio-economic differences in cardiovascular disease and physical activity: stereotypes and reality

Cardiovascular disease (CVD) is patterned by socio-economic status, being more common in lower social classes. Since physical inactivity is a risk factor for CVD it might be assumed that it is more common in lower social classes. We examine major recent UK population surveys and show that this assumption is incorrect; although higher social class adults engage in more formal sports activities, they are less likely to engage in other (e.g. occupational) activities. Lower social class children are more likely to engage in sports and active play. We also show that although Scotland has higher rates of CVD than England, it does not have higher prevalences of all CVD risk factors.
Performing The Soundscape With Third Age Adults:The Derry Soundscape Project

This paper will focus on a creative process that took place in Derry Northern Ireland in June of 2014 and culminated with the production of a CD of sound art works. The project engaged a group of older adults, who were members of the University for the Third Age (U3A) in Derry, to explore sound art through mobile technologies. During a two-week workshop period these participants recorded various soundscapes within Derry, edited and designed sounds on mobile technologies, and created a series of sonic art works for publication. The following paper discusses the processes and practices used to introduce sound art and technology to this group.
A Proposed API for Batched Basic Linear Algebra Subprograms

This paper proposes an API for Batched Basic Linear Algebra Subprograms (Batched BLAS). We focus on many independent BLAS operations on small matrices that are grouped together as a single routine, called Batched BLAS routine, with the aim of providing more efficient, but portable, implementations of algorithms on high-performance manycore architectures (like multi/manycore CPU processors, GPUs, and coprocessors).
Institutional Quality as a Determinant for FDI Inflows: Evidence from ASEAN

Since the 1980s ASEAN has become an important avenue for FDI from the rest of the world. However, as the importance of FDI as a new source of economic growth engine has been recognized by many, especially other developing countries, other parts of the world are also becoming interested in attracting FDI to their countries. With the current intense competition in attracting FDI, inevitably, ASEAN has to create a better and more conducive business environment to enable it to retain the existing inflows as well as attract others to invest in Malaysia. One avenue that has not been intensively touched so far concerns the role of institutional quality in explaining the behavior of FDI inflows into ASEAN. The result of the analysis reveals the important and significant role of institutional quality in attracting FDI inflows into ASEAN. Field of Research: Foreign Direct Investment, Developing economies
NEW SECURE SOLUTIONS FOR PRIVACY AND ACCESS CONTROL IN HEALTH INFORMATION EXCHANGE

OF DISSERTATION NEW SECURE SOLUTIONS FOR PRIVACY AND ACCESS CONTROL IN HEALTH INFORMATION EXCHANGE In the current digital age, almost every healthcare organization (HCO) has moved from storing patient health records on paper to storing them electronically. Health Information Exchange (HIE) is the ability to share (or transfer) patients’ health information between di↵erent HCOs while maintaining national security standards like the Health Insurance Portability and Accountability Act (HIPAA) of 1996. Over the past few years, research has been conducted to develop privacy and access control frameworks for HIE systems. The goal of this dissertation is to address the privacy and access control concerns by building practical and e cient HIE frameworks to secure the sharing of patients’ health information. The first solution allows secure HIE among di↵erent healthcare providers while focusing primarily on the privacy of patients’ information. It allows patients to authorize a certain type of health information to be retrieved, which helps prevent any unintentional leakage of information. The privacy solution also provides healthcare providers with the capability of mutual authentication and patient authentication. It also ensures the integrity and auditability of health information being exchanged. The security and performance study for the first protocol shows that it is e cient for the purpose of HIE and o↵ers a high level of security for such exchanges. The second framework presents a new cloud-based protocol for access control to facilitate HIE across di↵erent HCOs, employing a trapdoor hash-based proxy signature in a novel manner to enable secure (authenticated and authorized) on-demand access to patient records. The proposed proxy signature-based scheme provides an explicit mechanism for patients to authorize the sharing of specific medical information with specific HCOs, which helps prevent any undesired or unintentional leakage of health information. The scheme also ensures that such authorizations are authentic with respect to both the HCOs and the patient. Moreover, the use of proxy signatures simplifies security auditing and the ability to obtain support for investigations by providing non-repudiation. Formal definitions, security specifications, and a detailed theoretical analysis, including correctness, security, and performance of both frameworks are provided which demonstrate the improvements upon other existing HIE systems.
Binding interaction between polycyclic aromatic compounds and DNA by fluorescence displacement method

Noncovalent interaction of polycyclic aromatic compounds (PACs) with DNA is the first step in their DNA‐damaging actions. The binding interaction of 15 PACs with DNA was investigated by the fluorescence displacement method. A DNA‐binding dye with known binding mode was employed as the fluorescence probe. Addition of a DNA‐binding PAC into the dye/DNA conjugate sets up a competition between the probe and the PAC for DNA and results in a reduction in fluorescence signal. When thiazole orange, a DNA intercalator, was employed as the probe, the dissociation constants of 1‐hydroxypyrene, 1‐aminopyrene, and 1‐pyrenebutyric acid with calf thymus DNA were determined to be 0.62, 1.1, and 4.7 μM, respectively. Other PACs, with two to five fused aromatic rings, showed displacement similar to that of 1‐pyrenebutyric acid. When the DNA groove‐binding agents Hoechst 33258 and 4′,6‐diamidino‐2‐phenylindole were used as the probe, none of the PACs exhibited any significant competition with the probe for DNA. The fluorescence data and the viscosity measurement revealed that these PACs interact with DNA predominantly by intercalation instead of the groove‐binding mode. The results also suggested that the polar groups on the periphery of the PACs aromatic ring play a more important role than the number of aromatic rings in determining the binding affinities with DNA. The fluorescence displacement method provides a convenient tool for rapidly investigating the relationship between PAC structure and its DNA‐binding properties.
Withdrawal of repeated morphine enhances histamine-induced scratching responses in mice

Abstract An itch is experientially well known that the scratching response of conditions such as atopic dermatitis is enhanced under psychological stress. Morphine is typical narcotic drug that induces a scratching response upon local application as an adverse drug reaction. Although long-term treatment with morphine will cause tolerance and dependence, morphine withdrawal can cause psychologically and physiologically stressful changes in humans. In this study, we evaluated the effects of morphine withdrawal on histamine-induced scratching behavior in mice. Administration of morphine with progressively increasing doses (10–50 mg/kg, i.p.) was performed for 5 consecutive days. At 3, 24, 48, and 72 hr after spontaneous withdrawal from the final morphine dose, histamine was intradermally injected into the rostral part of the back and then the number of bouts of scratching in 60 min was recorded and summed. We found that at 24 hr after morphine withdrawal there was a significant increase in histamine-induced scratching behavior. The spinal c-Fos positive cells were also significantly increased. The relative adrenal weight increased and the relative thymus weight decreased, both significantly. Moreover, the plasma corticosterone levels changed in parallel with the number of scratching bouts. These results suggest that morphine withdrawal induces a stressed state and enhances in histamine-induced scratching behavior. Increased reaction against histamine in the cervical vertebrae will participate in this stress-induced itch enhancement.
Steady state behavior of normalized frequency domain adaptive filter in noncausal circumstances

Normalized frequency domain LMS algorithm is attractive due to its low computational burden and fast convergence speed. However, it suffers from the deteriorated steady-state behavior in noncausal circumstances, which is always inevitable in many application scenarios. In this paper, the influence of several factors on the steady state behavior of the normalized frequency domain LMS algorithm is investigated in a typical noncausal condition - a compact active noise control system. It is very interesting to find that the noise reduction performance is even worse with the increase of the control filter length.
Complaining Behavior in the Service Context: Evidence from Benin City

This paper explores complaining behaviour with respect to restaurant and interstate transport services in Benin City metropolis. It examines proportion of service customers who are dissatisfied and complained, complaint motivation and factors influencing complaint voicing in the restaurant and interstate transport service subsectors. Using the survey research design, responses obtained from 371 respondents were analysed using binomial analysis, chi square and multiple regression at a 0.05 level of statistical significance. Content analysis was employed for open ended questions. Results from the study showed that while there was no significant difference between the proportion of customers who were satisfied and those dissatisfied with the service offering in both subsectors, there was also no significant difference between the proportion of dissatisfied customers who complained and those who did not. Complaint voicing in the selected service subsectors was found not to be dependent on gender, age, educational level, usage frequency, income level, personal confidence of customer, cost of service or severity of service failure. Based on the findings, the authors suggest that there is need for restaurants and interstate transport companies in Nigeria to develop formal complaint management systems. Procedures for consumer complaints should be simple and involve little or no documentation as customers in the subsectors studied seem not to be favourably disposed to putting their complaints in writing.
Research on Time Synchronization in Cluster Robots Based on Wireless Network

Wireless Sensor Network based on clustering robots are designed, clock synchronization principle of wireless network and typical time synchronigation algorithms are researched. The time synchronization algorithm based on send/receive proposed two-way synchronization mechanism and the flooding algorithm improve in combination with TPSN and FTSP algorithm; the key factors affecting the accuracy are analysis ;synchronization error between nodes are estimated ;the time synchronization errors for the whole network are estimated. The experimental results show the requirements of this clustering robots wireless network, time synchronization accuracy, scope and efficiency are meeted the cluster about the algorithm that are proposed in this paper in terms of time synchronization accuracy and energy consumption tradeoffs.
Caldanaerovirga acetigignens gen. nov., sp. nov., an anaerobic xylanolytic, alkalithermophilic bacterium isolated from Trego Hot Spring, Nevada, USA.

An anaerobic thermophilic bacterium, designated strain JW/SA-NV4(T), was isolated from a xylan-supplemented enrichment culture from Trego hot spring located within the Black Rock Desert (NV, USA). Cells were generally straight or slightly bent rod-shaped, 0.4-0.8 microm in width and 3-6 microm in length during exponential growth. Cells from stationary phase were variable in size and shape, showing curved or bent morphology. Motility was not seen and flagella were not observed in electron micrographs. Sporulation was not observed. Strain JW/SA-NV4(T) stained Gram-negative but is phylogenetically Gram-type positive. Growth occurred at pH(25 degrees C) 6.8-8.8, with optimum growth at pH 8.4; no growth occurred at pH 9.0 or above or at 6.5 or below. With glucose or xylose as the carbon source, strain JW/SA-NV4(T) grew at 44-74 degrees C; no growth occurred at 76 degrees C or above or at 42 degrees C or below. However, the optimum temperature was 62 and 66 degrees C when grown on glucose and xylose, respectively. The shortest doubling time observed with glucose was approximately 4 h, and with xylose approximately 3.4 h. Strain JW/SA-NV4(T) tolerated an atmosphere containing up to 0.1 % O(2); no growth occurred at a gas atmosphere of 0.2 % O(2). Chemo-organotrophic growth occurred with xylose, glucose, mannose, xylan, pyruvate, fructose, ribose, Casamino acids, mannitol, tryptone, peptone, cellobiose and yeast extract. When grown in mineral media containing 1 g yeast extract l(-1) as an electron donor, thiosulfate and sulfur were reduced to sulfide. The G+C content of the DNA was 38.6 mol% (HPLC). 16S rRNA gene sequence analysis placed strain JW/SA-NV4(T) within the order Thermoanaerobacterales and within the Thermoanaerobacterales Incertae Sedis Family III, specifically between taxa classified within the genera Thermosediminibacter and Thermovenabulum. The closest phylogenetic neighbours were Thermosediminibacter oceani JW/IW-1228P(T) (94.2 % 16S rRNA gene sequence similarity) and Thermosediminibacter litoriperuensis JW/YJL-1230-7/2(T) (94.0 %) [Lee, Y. -J., Wagner, I. D. , Brice, M. E. , Kevbrin, V. V. , Mills, G. L. , Romanek, C. S. & Wiegel, J. (2005). Extremophiles 9, 375-383]. Based on physiological and genotypic characteristics, strain JW/SA-NV4(T) (=DSM 18802(T)=ATCC BAA-1454(T)) is proposed to represent the type strain of a novel species in a novel genus, Caldanaerovirga acetigignens gen. nov., sp. nov.
Considerations for the End-User: Standards, Collaboration, and Participation

The development of efficient and effective virtual reality (VR) rehabilitation systems requires an intimate understanding of function, disability, and the end-user. This chapter presents three aims: 1) provide an overview of United States and international rehabilitation legislation and initiatives related to rehab technology; 2) examine types of rehabilitation therapy (occupational, physical, and speech) and the importance of on-going inter-disciplinary collaboration with computer engineers; and 3) expand knowledge of factors that influence end-users participation in VR rehabilitation, which includes usertechnology match, and device compliance. Consideration of these aims will help computer engineers and researchers create VR rehabilitation systems through a collaborative and user-centered approach that meet international standards of practice.
Identification of PDZ Domain Containing Proteins Interacting with Cav 1 . 2 and PMCA 4 b

PDZ (PSD-95/Disc large/Zonula occludens-1) protein interaction domains bind to cytoplasmic protein C-termini of transmembrane proteins. In order to identify new interaction partners of the voltage-gated L-type Ca channel Cav1.2 and the plasma membrane Ca ATPase 4b (PMCA4b), we used PDZ domain arrays probing for 124 PDZ domains.We confirmed this byGST pulldowns and immunoprecipitations. In PDZ arrays, strongest interactions with Cav1.2 and PMCA4bwere found for the PDZdomains of SAP-102, MAST-205, MAGI-1, MAGI-2, MAGI-3, and ZO-1. We observed binding of the Cav1.2 C-terminus to PDZ domains of NHERF1/2, Mint-2, and CASK. PMCA4b was observed to interact with Mint-2 and its known interactions with Chapsyn-110 and CASK were confirmed. Furthermore, we validated interaction of Cav1.2 and PMCA4b with NHERF1/2, CASK, MAST-205 and MAGI-3 via immunoprecipitation.We also verified the interaction ofCav1.2 andnNOS andhypothesized that nNOSoverexpression might reduce Ca influx through Cav1.2. To address this, we measured Ca 2+ currents in HEK 293 cells co-expressing Cav1.2 and nNOS and observed reduced voltage-dependent Cav1.2 activation. Taken together, we conclude that Cav1.2 and PMCA4b bind promiscuously to various PDZ domains, and that our data provides the basis for further investigation of the physiological consequences of these interactions.
A causal study of an emulated network

With the diversity of applications and technologies present in communication networks, the study of their performance has become a complex issue. The large number of parameters to take into account to model communication network performance increases the risk of spurious associations between the explanatory variables. Therefore studies based on correlation become a challenging approach. On the other hand, causal models, and their representation as Directed Acyclic Graphs (DAGs), offer simple and attractive models. Using simple graphical criteria, one can predict interventions on the system by using data collected through passive measurements. In this paper, we present an example of a causal study of communication network performance.We place ourselves in an emulated environment, where our predictions can be verified, and we show the benefits of the approach.
E-Innovation as Source of Business Value in Firms

This chapter seeks to assess the relationship between Web infrastructure and Internet-based innovation as sources of business value. To respond to this challenge, a conceptual model, grounded in the resourcebased view (RBV) is developed. To test hypotheses, a large sample consisting of Spanish firms is employed. The results show that, as hypothesized, Web infrastructure is not positively related to business value and that Internet-based innovation has a positive significant impact on business value. In addition, the results show no significant complementarity between Web infrastructure and Internet-based innovation. DOI: 10.4018/978-1-61520-871-5.ch008
A Phase 1 Study of Mapatumumab (Fully Human Monoclonal Antibody to TRAIL-R1) in Patients with Advanced Solid Malignancies

Purpose: Mapatumumab (TRM-1, HGS-ETR1) is a fully human agonistic monoclonal antibody that targets and activates tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) receptor 1 (death receptor 4). Mapatumumab functions like the natural receptor ligand, TRAIL, a tumor necrosis factor superfamily member that is an important mediator of apoptosis in cancer cell lines. Promising preclinical activity with mapatumumab has been observed. Experimental Design: This phase I, open-label, dose-escalation study assessed the tolerability and toxicity profile of ≥2 doses of mapatumumab administered i.v. in patients with advanced solid tumors. Patients received mapatumumab every 28 days until progression or dose-limiting toxicity. Results: There were escalation levels from 0.01 to 20.0 mg/kg. Forty-one patients, 27 female, with a median age of 55 years (range, 23-81) were entered into the study and received 143 courses. The most common diagnoses were colorectal (10 patients) and ovarian cancer (9 patients). Patients received a median of two cycles (range, 1-33). Mapatumumab was well tolerated. Adverse events considered at least possibly related to mapatumumab that occurred most frequently included fatigue (36.2%), hypotension (34.1%), nausea (29.3%), and pyrexia (12.2%). The majority of adverse events were grade 1 or 2. The maximum tolerated dose was not reached. Linear pharmacokinetics was observed for doses up to 0.3 mg/kg and for the 20 mg/kg level, whereas exposure at 3 and 10 mg/kg increased less than proportionally. No objective responses were observed, but 12 patients had stable disease for 1.9 to 29.4 months. Conclusions: Mapatumumab is well tolerated and further evaluation of this TRAIL-R1 targeting agent is warranted.