Miracle-dz/UniFAR-FTUs huggingface dataset:
Behandlung von Rindern mit Bösartigem Katarrhalfieber mit Interleukin-2.

The goal of this study was to investigate whether administration of interleukin-2 (IL-2) would improve the outcome of cows with malignant catarrhal fever (MCF). The study population consisted of ten healthy control cows and 22 cows with MCF. Nineteen cows with MCF and all of the controls were treated with either 2‘500 U IL-2 or 25‘000 U IL-2, administered intravenously. Three cows with MCF were not treated with IL-2 (MCF controls). All of the cows with MCF received danofloxacin, flunixin meglumine and intravenous fluid therapy. Blood samples for haematological and biochemical evaluation were collected once daily for six days in all cows. Of the 19 cows treated with IL-2, 13 were euthanized because of deterioration. All cows with MCF that did not receive IL-2 died. The clinical condition of six cows treated with 2‘500 U IL-2 gradually improved. Surviving cows had significantly higher total leukocyte counts than cows that died or were euthanized. The main reason for leukopenia in non-surviving vs. surviving cows was persistent lymphopenia. Use of the lower IL-2 dose was associated with clinical recovery in some cows and this treatment might therefore be considered in valuable cows, provided that the lymphocyte count is within the reference interval.
Modeling and Performance Prediction of IP Multimedia Subsystem Networks

RAJAGOPAL, NISHA. Modeling and Performance Prediction of IP Multimedia Subsystem Networks. (Under the direction of Professor Michael Devetsikiotis). IP Multimedia Subsystem (IMS) is envisioned as the solution for the next generation multimedia rich communication. Based on an open IP infrastructure, IMS enables access independent convergence of data, speech, video and mobile network technologies. Session Initiation Protocol (SIP) is the signaling protocol of choice for IMS. In this thesis, we propose service models for IMS networks with utility functions. These service models act as control mechanisms to optimize network properties. We analyze the IMS network based on the SIP signaling delay and predict performance trends of the network. Our focus is on the formulation of queueing models for the IMS network and characterization of the SIP server workload. This approach of theoretical evaluation combined with realistic performance characterization can be used for designing IMS networks with optimal performance. Our analysis is based on a careful study of real-life SIP network traffic. Modeling and Performance Prediction of IP Multimedia Subsystem Networks
Les corynébactéries, aspects bactériologiques et cliniques

Les corynebacteries se definissent par une morphologie de bacilles irreguliers non sporules qui presentent une coloration de Gram positive. En fait, cette denomination recouvre des bacteries tres distinctes que ce soit d’un point de vue taxonomique, ecologique ou de la pathologie associee. Elles constituent une partie importante de la flore de la peau et des muqueuses et peuvent egalement se retrouver dans l’environnement. La description recente de nouvelles especes rend possible maintenant l’identification de la majorite des corynebacteries isolees de prelevements humains. L’association a certaines infections a pu etre etablie pour quelques-unes de ces nouvelles especes. La pathologie est encore dominee par la diphterie qui a resurgi recemment dans certains pays, mais d’autres corynebacteries, dont certaines presentent une multiresistance aux antibiotiques, peuvent etre responsables d’infections nosocomiales. Ainsi, le pouvoir pathogene de Corynebacterium urealyticum a ete reconnu dans des infections urinaires survenant en milieu urologique et Corynebacterium jeikeium est frequemment retrouvee a partir de divers materiels implantes et peut etre a l’origine de septicemies. D’autres corynebacteries ont pu etre reliees a des infections, telles C. seminale responsable de prostatites, Turicella otitidis isolee d’otites moyennes aigues et Arca-nobacterium haemolyticum qui est responsable de pharyngites chez l’adolescent. Enfin, les bacteries du genre Actinomyces sont classiquement les agents des actinomycoses, mais sont aussi responsables d’abces en association avec une flore anaerobie. Les bacteries composant les actinomycetes aerobies, notamment Rhodococcus equi, ont ete isolees d’infections opportunistes survenant le plus souvent chez des patients immunodeprimes. La classification actuelle permet d’identifier la majorite des corynebacteries isolees en bacteriologie medicale. Cette identification doit etre realisee des lors que ces bacteries sont en situation potentiellement pathogene.
Percutaneous Ethanol Injection Therapy for Liver Neoplasms

Percutaneous ethanol injection therapy (PElT), which was first reported by Sugiura et al in 1983,' has been widely performed in the treatment of liver neoplasms, especially hepatocellular carcinoma (HCC). 25 Histopathologic examinations after the therapy have revealed that PElT can destroy the tumor completely in most cases.8 Follow up imaging studies and serum tumor marker assays have attested to the remarkable anticancer effect of this procedure.9'° In addition, PElT has resulted in impressive long-term survival rates.12 There were three factors in the introduction of PElT. First, there were no satisfactory therapies for HCC. Although more and more cases of subclinical HCCs are being found by screening of high-risk subjects such as hepatitis virus carriers and patients with chronic liver disease,'3 the resectability rate of this cancer is strikingly low. For example, according to' the latest report of The Liver Cancer Study Group of Japan, only 3065 of 10,082 HCCs (30.4%) were resected. '4 Most patients with HCC already have intrahepatic metastases at the time of diagnosis, or severe liver dysfunction secondary to cirrhosis often makes hepatectomy impossible even in early HCCs. Also, the cancer very frequently recurs, even after curative resection of the lesion. '5-'7 Transcatheter arterial embolization has been widely used and has achieved remarkable results in the treatment of unresectable HCCs.18,19 However, transcatheter embolization cannot be curative in many cases because of its ineffectiveness against intercapsular, extracapsular, or vascular invasion.19 In addition, its anticancer effect may be canceled out in the treatment of small HCCs2O because the embolization seems to damage noncancerous liver parenchyma.2' Various types of chemotherapy have been tried in unresectable cases. However, regardless of the types of agents and the routes of administration, the results have not been satisfactory.22 Thus, invention of therapies for HCC that could be curative and did not damage noncancerous liver parenchyma evolved. A second factor was the improvements in ultrasonography that made it possible to guide needles percutaneously into abdominal organs precisely and safely. Various therapeutic procedures using ultrasound guidance were introduced, such as percutaneous transhepatic bile drainage for obstructive jaundice23 and percutaneous abscess drainage.24 Third, absolute ethanol has been widely used in various therapeutic procedures, such as transcatheter arterial embolization of renal tumors,25 thrombotherapy of esophageal varices,26 and percutaneous injection in secondary hyperparathyroidism.27 In PElT, absolute ethanol is injected into lesions through fine needles under ultrasonographic observation.
FRI0404 Disturbances of T and B Cell Homeostasis Characterized Primary Antiphospholipid Patients During their Follow-Up of Venous Thromboembolism

Background During the last decade, it was observed that peripheral blood lymphocyte subset distribution was altered in autoimmune diseases such as systemic lupus erythematosus (SLE), primary Sjögren's syndrome (pSS), mixed connective tissue disease, multiple sclerosis, and ANCA-associated vasculitis. Objectives Accordingly, our aim was to evaluate in the follow-up of patients with venous thromboembolism (VTE) whether lymphocyte distribution is altered in well-characterized primary antiphospholipid syndrome (pAPS) patients. Methods A prospective, descriptive and comparative study was conducted at Brest University Medical School (France) from June to October 2013. Cases of pAPS VTE patients were selected from the data base EDITH (Study of Determinants Interactions of venous thrombosis), which is a monocentric case-control cohort. From this data base, eleven pAPS VTE patients selected during their follow-up were included and matched with non-APS VTE patients, autoimmune disease patients (Sjögren's syndrome and systemic lupus erythematosus) and controls. Using a 4 colors flow cytometer, peripheral blood B cell subsets (B1, transitional, naïve, and memory), T cell subsets (CD3, CD4, CD8) and NK-cells were explored. Results In contrast to non-APS VTE patients and controls, pAPS VTE patients displayed total CD3 and CD8 naïve (CD45RA+ CD27+) T cell reduction, and disturbance in B cell homeostasis with increased proportions of B1 cells, transitional B cells (CD24++ CD38++) and naïve B cells (IgD+CD27-), while unswitched (IgD+CD27+) and switched (IgD-CD27+) memory B cells were reduced. The unswitch memory B cell percentage, and even better the naïve/unswitched memory B cell ratio were both effective to distinguish pAPS VTE patients from non-APS VTE patients, and from patients with autoimmune diseases. Interestingly, the absolute number of CD4 T cells was positively correlated with IgG anti-cardiolipin antibody levels. Conclusions In summary, this study, although conducted with a limited number of well characterized pAPS patients, revealed two major points. First, disturbances in B cell homeostasis that can be used as a signature for pAPS, and second an association between the CD4+ T cell subset and the production of IgG aCL Ab. Future studies shall address whether these perturbations would be helpful for the diagnosis and/or for the therapeutic management and follow-up of these patients. Disclosure of Interest None declared
Alternativas terapêuticas em modelos experimentais de doença inflamatória intestinal - DOI: 10.4025/cienccuidsaude.v7i0.6580

Experimental models of inflammatory bowel disease (IBD) supply considerable information on the pathogenesis of this illness and represent an important tool in testing new strategies of treatment. Crohn’s disease (CD) is an idiopathic, chronic inflammatory condition of the intestinal tract that causes structural and functional changes in the enteric nervous system (ENS), and for which therapeutics options are limited. The use of natural products as alternative therapy for CD has been intensively investigated in animal models of IBD. This review summarizes the major structural abnormalities of the ENS in animal models of Crohn’s disease and the effects of natural products in the inflammatory process. The bibliographical research, of descriptive character, comprises a period of 10 years and was carried through consultation of printed materials and the database of Literatura Latino Americana em Ciencias da Saude e do Caribe (LILACS) and in the National Library of Medicine (MEDLINE), displayed in electronic support. Books have also been used.
ANALISIS PERSISTENSI INFLASI JAWA TIMUR : SUATU PENDEKATAN SISI PENAWARAN

Inflasi adalah proses meningkatnya harga-harga barang secara umum dan terus menerus. Inflasi juga merupakan proses menurunnya nilai mata uang secara terus-menerus. Inflasi adalah indikator untuk melihat tingkat perubahan, dan dianggap terjadi jika proses kenaikan harga berlangsung secara terus-menerus dan saling pengaruh-mempengaruhi. Perilaku dari inflasi dapat dipelajari melalui persistensi inflasi. Persistensi inflasi merupakan perilaku yang sering ditemukan di banyak negara maupun wilayah tertentu, tidak terkecuali di Indonesia dan provinsi-provinsinya. Persistensi inflasi merupakan cepat lambatnya inflasi untuk kembali ke nilai alamiahnya ketika terjadi guncangan (shock) yang menyebabkan inflasi menjauh dari nilai alamiahnya tersebut. Derajat persistensi yang tinggi menunjukkan lambatnya tingkat inflasi ke tingkat alamiahnya. Sebaliknya derajat persistensi yang rendah menunjukkan cepatnya tingkat inflasi untuk kembali ke tingkat alamiahnya. Shock dimaksud antara lain dapat berupa kebijakan pemerintah, gangguan distribusi, bencana alam dan perubahan cuaca. Penelitian ini bertujuan untuk mengukur derajat persistensi inflasi di Jawa Timur dan juga untuk mengetahui sumber-sumber dari persistensi inflasi tersebut terutama dari sisi penawaran. Pada penelitian ini juga akan membahas tentang pengendalian inflasi dari sisi penawaran yang dilakukan oleh Tim Pengendali Inflasi Daerah (TPID). Penelitian ini menggunakan model univariate yaitu model autoregressive (AR) time series untuk mengestimasi derajat persistensi inflasi. Dengan menggunakan data bulanan dalam masa pengamatan 2006-2012, penelitian menemukan derajad persistensi inflasi di Jawa Timur masih tinggi. Sumber utama penyebab munculnya persistensi inflasi terkait shock yang terjadi pada komponen administered price yang diwakili oleh kelompok perumahan, air, listrik, gas dan bahan bakar dan juga pada kelompok volatile foods yang diwakili oleh kelompok bahan makanan. Penelitian ini juga menemukan bahwa jangka waktu yang dibutuhkan oleh kelompok pengeluaran untuk kembali kenilai alamiahnya selama 8 hingga 16 bulan. Sedangkan untuk adanya pembentukan Tim Pengendali Inflasi Daerah (TPID) telah memberikan pengaruh yang baik bagi persistensi inflasi Jawa Timur. Setelah dibentuknya TPID, persistensi inflasi Jawa Timur cenderung mengalami penurunan. Implikasi dari temuan di atas yaitu dapat menjadi acuan dalam menentukan timing dalam menentukan kebijakan oleh pemerintah. Disamping itu untuk mengendalikan inflasi yang disebabkan oleh anomaly cuaca, TPID dapat menjalin kerjasama dengan Badan Meteorologi dan Geofisika (BMKG) dan Badan Pengkajian dan Penerapan Teknologi (BPPT) untuk memantau cuaca serta melaksanakan Teknologi Modifikasi Cuaca (TMC) dalam rangka pemanfaatan teknologi untuk mengurangi dampak dari perubahan cuaca. Kata Kunci: Persistensi Inflasi, Administered Price, Volatile Foods, Tim Pengendali Inflasi Daerah, Autoregressive.
Production Planning Models using Max-Plus Algebra

The chapter presents a novel building block approach to developing models of manufacturing systems. The approach is based on max-plus algebra. Within this algebra, manufacturing schedules are modeled as a set of coupled linear equations. These equations are solved to find performance metrics such as the make span. The chapter develops a generic modeling block with three inputs and three outputs. It is shown that this structure can model any manufacturing system. It is also shown that the structure is hierarchical, that is, a set of blocks can be reduced to a single block with the same three inputs and three output structure. Basic building blocks, like machining operations, assembly, and buffering are derived. Job shop, flow shop, and cellular system applications are given. Extensions of the theory to buffer allocation and stochastic systems are also outlined. Finally, several numerical examples are given throughout the development of the theory.
Results of the Transplantation of Blood Vessels, Organs and Limbs

INTRODUCTION. The idea of replacing diseased organs by sound ones, of putting back an amputated limb or even of grafting a new limb on a patient having undergone an amputation, is doubtless very old. The performance of such operations, however, was completely prevented by the lack of a method of uniting vessels, thus re-establishing a normal circulation through the transplanted structures. The feasibility of these grafts depended on the development of the technic. The history of vascular surgery is too well known to need repetition. It recently reached the active stage of its development with the experiments of Murphy in Chicago and of Payr in Gratz. Murphy united the arteries by invagination and suture, while Payr used a magnesium tube. The remarkable experiments performed in 1903 by Hoepfner with the method of Payr gave an illustration of what could be obtained in vascular surgery by a proper method. Finally a
If Functional Programming Is SoGreat, Why Isn't Everyone Using It?

Functional programming has been considered to be an answer to many of the problems faced by software engineering today, especially in academic circles. Nevertheless, the large-scale adoption of functional programming in the mainstream of industry has been sluggish. Although there are a lot of different opinions about the underlying problem to this issue, it is hard to find literature that elaborates on the topic. This report presents the results of a meta-study conducted on multiple aspects of the functional programming paradigm and its representing languages. It does so by identifying key issues responsible for the weak adoption of functional program- ming, and, more importantly, by proposing and evaluating measures that should positively influence the usage of functional programming languages in industrial, commercial and practical settings.
Postpartum Maternal Weight Changes: Implications for Military Women

Abstract : We have completed recruitment, data collection and data entry for this study group of new mothers attending the well-baby clinic at the Naval Medical Center, San Diego. We enrolled more than 2500 eligible women and obtained essential data from 1652 of them. Data on the major endpoint, maternal weight late in the postpartum year, are available for more than 1600 of these women, and longitudinal data, reflecting weight measures during the early, middle and late periods of the postpartum year, are available for 861 women. Approximately 20% of the study participants are active duty women. Women in this study, on average, retained more weight late in the postpartum year than usually reported (about 4 kg in this study compared to means of 1.5 to 2 kg in previous studies). Approximately 25% of women who began pregnancy with normal BMI became overweight after birth; the prevalence of overweight was even higher among certain subgroups. Results so far suggest some social, demographic and behavioral risk factors that appear related to increased postpartum weight retention in both active duty and dependent mothers. Additional analyses in the coming year will contribute more information on factors and behaviors that may increase, or protect against, maternal obesity after pregnancy.
Middle Eastern mythology

Professor Hooke shows how mythology can play a role in ritual, how it can explain the origin of a custom or cult and glorify a hero, tribe or city. All of these functions are relevant to the strange and haunting myths of the Mesopotamians, Egyptians, Canaanites and Hittites, slowly revealed by decades of archaeological research and retold here. Yet it is also these early religious traditions that underlie the familiar stories of Genesis, Noah's flood and the Garden of Eden. Even the Nativity and Resurrection narratives, whatever their basis in fact, can be paralleled elsewhere. We ought, in other words, to consider the Middle East as a single unit and to look at the Bible in that context.
Treatment options for psoriatic arthritis

Introduction: Recent years have witnessed tremendous development in the treatment of patients with psoriatic arthritis (PsA). Driven by greater understanding of the immunopathogenesis of disease, a number of novel treatment approaches have been developed and brought to the clinic. Additional therapies and treatment strategies are being explored. Areas covered: This paper discusses conventional and novel therapeutic options for treatment of PsA including agents under development. Novel treatment paradigms are also considered. Expert opinion: With newer therapies, in particular TNF inhibitors, treatment outcomes for patients with PsA have substantially improved. This has driven in advances in the approach to assessment of PsA, including composite measures of disease activity. Furthermore, novel treatment paradigms such as treat to target, early diagnosis and treatment, and consideration of tapering therapy among patients achieving low levels of disease activity are being actively explored. With these exciting developments, it is likely that outcomes for patients with PsA will continue to be improved in the foreseeable future.
The Use of an Expert System to Dynamically Alter Web Pages for One-to-One Marketing

One-to-one marketing on the Web is in its infancy. The Web offers a unique opportunity to mass market products directly to potential buyers who have a high probability for purchase, and to do so at a low cost. The key to unleashing this potential is the tailoring of Web presentation to address individual needs and desires quickly. This capability requires a mechanism for change so the site can adapt to the user. It also requires the ability to store and quickly access databases. We believe that an expert system is uniquely capable of providing this ability.
Archéologie et paléoenvironnement sur le site du pont romain des Esclapes (Fréjus, Var)

Cet article presente les resultats paleoenvironnementaux et archeologiques acquis sur le site du pont romain des Esclapes, a 1,5 km a l’ouest de Frejus (Var, France). La presence isolee de l’edifice dans le paysage, actuellement eloigne des voies de passage et des cours d’eau de la vallee, posait la question de l’evolution des milieux depuis l’Antiquite. Sur la base de ce constat, l’objectif des travaux engages sur le site etait de definir la nature des milieux a l’epoque romaine en precisant la nature du cours d’eau qui passait sous le pont et l’aspect du couvert vegetal des environs immediats du site. Le volet paleoenvironnemental de l’etude a ete realise a partir de l’examen de trois carottes sedimentaires prelevees sur le site qui ont fait l’objet d’analyses sedimentologiques, palynologiques, carpologiques et microfaunistiques (ostracodes et coquilles marines). Les paleo-paysages observes ont ete dates par 14C (5 datations AMS). Les resultats presentes offrent un panorama des environnements depuis 4700 BP cal. a nos jours. Le paysage evolue a partir d’un milieu d’embouchure vers une lagune d’abord ouverte puis fermee, qui cede la place a la plaine alluviale actuelle. L’epoque romaine correspond a la transition entre la lagune ouverte et la lagune en voie de fermeture. Ces donnees affinent la connaissance des paleo-paysages de la basse vallee de l’Argens et permettent de mieux comprendre ses modes de peuplement et d’exploitation.