Miracle-dz/UniFAR-FTUs huggingface dataset:
Plasma HDL cholesterol, triglycerides, and adiposity. A quantitative genetic test of the conjoint trait hypothesis in the San Antonio Family Heart Study.

BACKGROUND The conjoint trait hypothesis proposes that combined low HDL cholesterol (HDL-C) and high triglyceride (TG) levels represent a single, inherited phenotype that adiposity may influence in an unspecified manner. We conducted formal statistical genetic tests of the conjoint trait hypothesis and the relation of the conjoint trait to adiposity using data for 569 subjects in 25 pedigrees from the San Antonio Family Heart Study. METHODS AND RESULTS We conducted multivariate genetic analyses to detect the effects of genes and environmental factors on variation in plasma concentrations of HDL-C and TG, fat mass (as percent body weight [FM%], determined by bioelectric impedance), and body mass index (BMI). We used maximum-likelihood methods to simultaneously estimate the phenotypic means and SDs, heritabilities (h2), effects of sex, age-by-sex, eight dietary and medical covariates, and genetic and environmental correlations. Likelihood ratio tests disclosed significant heritabilities (P < .001) for all traits (h2HDL-C = 0.55, h2TG = 0.53, h2FM% = 0.37, h2BMI = 0.44) but significant genetic correlations (P < .001), indicating pleiotropy, between two trait pairs only: HDL-C and TG (PG = -0.52) and fat mass and BMI (PG = 0.86). We obtained significant environmental correlations between all trait pairs except HDL-C and BMI (P > .05). CONCLUSIONS Both shared genes (pleiotropy) and shared environmental factors contribute to the commonly observed inverse phenotypic association between plasma levels of HDL-C and TG. Rather than low HDL-C and high TG being a single, genetically transmissible entity, it is the inverse relation between these two phenotypes throughout their normal ranges of variation as well as at the extremes that is influenced by shared genes and shared environments. However, common environmental factors, not shared genes, account for reported associations of plasma HDL-C and TG levels with measures of adiposity.
Balancing exploration with exploitation-solving mazes with real numbered search spaces

A hybrid architecture, called EXP1, automatically balances exploration and exploitation to solve mazes with large real numbered search spaces. It employs a genetic algorithm (GA) to search and optimise each movement. The GA fitness function is supplied by a radial basis function (RBF) neural network which acts as an adaptive heuristic critic (AHC). Over successive trials it learns the V-function, a continuous mapping between real numbered positions in the maze and the value of being at those positions. EXP1 solved all the mazes with which we tested it and proved to be quite robust to changes in internal parameters. <<ETX>>
Compressed sensing of compressible signals

A novel low-complexity robust-to-noise iterative algorithm named compression-based gradient descent (C-GD) algorithm is proposed. C-GD is a generic compressed sensing recovery algorithm, that at its core, employs compression codes, such as JPEG2000 and MPEG4. Through using compression codes, C-GD strongly generalizes the scope of structures used by compressed sensing recovery algorithms beyond sparsity or low-rankness. The squared error of the proposed method and its associated convergence is characterized and predicts the strong performance of C-GD. Numerical results suggest that C-GD, when combined with state-of-the-art compression codes, either outperforms or performs comparably to modern compressed sensing recovery methods.
Whole-Farm Mating Disruption to Manage Grapholita molesta (Lepidoptera: Tortricidae) in Diversified New Jersey Orchards

ABSTRACT Fruit orchards in New Jersey are usually isolated from neighboring farms and diversified, often containing separate plantings of peach (Prunus spp.) and apple (Malus spp.). These crops can suffer significant damage from oriental fruit moth, Grapholita molesta (Busck) (Lepidoptera: Tortricidae). This study evaluated the effect of managing G. molesta by using sex pheromone—based mating disruption applied to both peaches and apples (whole-farm mating disruption) rather than treating either crop alone. In year 1 of the experiment, G. molesta mating disruption applied to the adjacent peach and apple blocks provided better control than treating peaches or apples alone. During year 2, treating these adjacent blocks or only treating apples controlled G. molesta equally well. G. molesta populations were so low at the end of year 2 that mating disruption was not applied against this pest during year 3. This allowed us to determine whether applying mating disruption for two consecutive years controlled G. molesta well enough that it eliminated the need mating disruption for three consecutive years. The mean cumulative number of G. molesta captured in plots where both peaches and apples had been treated did not exceed two moths per trap in the third year of this experiment. In contrast, G. molesta capture rebounded during August in peaches and apples that had not been treated with mating disruption the previous 2 yr. Implications for managing G. molesta by using mating disruption as a “whole-farm” tactic as well applying it for two consecutive years and not a third year are discussed.
A millennial mindset: how modal shift affects the transportation choices of university students

Growing urban populations and the increasing prevalence of the millennial generation are profoundly changing personal travel behaviors and patterns. As a result, cities, planners, and developers must understand and act upon the shifting preferences and expectations of these public transit users in order to align costly public transit services with user needs in efficient ways. While public transit systems are becoming an increasingly vital part of urban life, few jurisdictions have considered the need to tailor these systems to millennials – those most likely to incorporate public transit into their daily lives. This paper examines the travel behaviors of University Students engaged in a forced travel intervention caused by a sudden relocation of their work site. The change in work location encouraged the use of a free public transit system as means of commuting. Longitudinal survey results, taken pre and post-intervention, indicate statistical differences between transit preferences and actual habits related to transit use and other modes of travel. Survey findings suggest that there is a statistically significant difference between the stated willingness and actual travel behaviors of public transit users and of drivers, and that modal shifts can assist in overcoming the attitude/behavior split related to personal travel among millennials. A MILLENNIAL MINDSET How modal shift affects the transportation choices of university students Jessica Weber Master of Regional and Community Planning Spring 2016 A MILLENNIAL MINDSET: HOW MODAL SHIFT AFFECTS THE TRANSPORTATION CHOICES OF UNIVERSITY STUDENTS
Effect of duty cycle in different frequency domains on SSVEP based BCI: A preliminary study

Compared with the well learned amplitude-frequency characteristic of Steady State Visual Evoked Potential (SSVEP), the effect of duty cycle is still unclear. In this work, the influence of duty cycle on SSVEP response is investigated in differnt frequency domains. The amplitude surface with the change of both frequencies and duty cycles is plotted. To get a stable response, the experiment arranged in 3 days, and each result is an average of 12 repetitions. It is interesting that the results from power spectral density (PSD) and canonical correlation analysis (CCA) method are not consistent. In addition, the relation between the fundamental component and its second harmonic component with the change of duty cycle is quite different at frequency of 7Hz, 10Hz and 13Hz. Based on the amplitude surface, we try to configure the subject-specific SSVEP based BCI. The frequencies and duty cycles of the stimulus are selected corresponding to the higher SSVEP response in the amplitude surface. Cross validation results show a significant improvement in the performance for the adjustment of duty cycle.
Primary prevention of cardiovascular disease using validated risk scores: A systematic review

Objectives The high prevalence of cardiovascular disease (CVD) and the increased cost of treatment have prompted strategies for the primary prevention of CVD in the UK to move towards the use of validated CVD risk scores to identify individuals at the highest risk. There are no reviews evaluating the effectiveness of this strategy as a means of reducing CVD risk or mortality. This review summarizes current evidence for and against the use of validated CVD risk scores for the primary prevention of CVD. Design We utilized an in depth search strategy to search MEDLINE, EMBASE and the Cochrane database of clinical trials, expert opinions were sought and reference lists of identified studies and relevant reviews were checked. Due to a lack of homogeneity in outcomes and risk scores used it was not possible to conduct a meta-analysis of the identified studies. Setting The majority of included trials were carried out in a primary care setting. 2 trials were carried out in North America, 2 in Scandinavia and 1 in the UK. Participants 31,651 participants in total were recruited predominantly from a primary care setting. Participants were aged 18-65 years old and were free from CVD at baseline. Main outcome measures Outcome measures used in the included studies were change in validated CVD risk score and CVD/All-cause mortality. Results We identified 16 papers which matched the inclusion criteria reporting 5 unique trials. Due to a lack of homogeneity in outcomes and risk scores used it was not possible to conduct a meta-analysis of the identified studies. Only one study reported a significant difference in risk score at follow up and one study reported a significant difference in total mortality, however significant differences in individual risk factors were reported by the majority of identified studies. Conclusions This review demonstrates the potential for multifactorial interventions aimed at individuals selected by CVD risk scores for lowering CVD risk and mortality. However, the majority of studies in this area do not provide an intensity of intervention which is sufficient in significantly reducing CVD mortality or validated CVD risk.
The nucleocapsid of hepatitis B virus is both a T-cell-independent and a T-cell-dependent antigen.

One characteristic of the immune response during hepatitis B virus (HBV) infection in humans is the vigorous production and subsequent persistence of antibodies of immunoglobulin (Ig) classes M and G to the nucleocapsid antigen (HBcAg). In this study HBcAg was shown to be similarly immunogenic in mice. When injected into athymic (nude) B10.BR and athymic BALB/c mice, HBcAg induced IgM and IgG class antibodies to HBc in spite of the absence of T cells in nude mice. In euthymic mice, HBcAg efficiently stimulated T-cell proliferation in vitro and helper T-cell function in vivo. The dual functions of HBcAg as a T-cell-independent and a T-cell-dependent antigen may explain its enhanced immunogenicity. Denaturation of HBcAg yields a nonparticulate antigen designated HBeAg; when HBeAg was used as the immunogen, antibody production required helper T-cell function. Although HBcAg and HBeAg are serologically distinct, they are structurally related, and in these experiments were highly cross-reactive at the T-cell level. These results suggest that the elevated levels of IgM antibodies to HBc and the enhanced immunogenicity of HBcAg during HBV infection in humans reflect the ability of HBcAg to directly activate B cells to produce antibodies to HBc in the presence or absence of HBcAg- or HBeAg-sensitized T cells.
Thalamic stimulation for the treatment of midline tremors in essential tremor patients

Article abstract The authors prospectively collected unblinded data from 27 consecutive patients following thalamic stimulation. A significant reduction of midline tremor was achieved after unilateral surgery, but a staged contralateral surgery had an additional effect. A subgroup analysis showed significant beneficial effects for head, voice, tongue, and face tremor. The most frequent reversible side effects were disequilibrium, dysarthria, and paresthesias. We observed more pulse generator adjustments for speech problems in the bilaterally implanted group.
Revisiting ligand-induced conformational changes in proteins: essence, advancements, implications and future challenges

Ligand-induced conformational changes are of immense importance for the biological activity of a protein. An in-depth understanding of salutary and deleterious effects of ligand-induced conformational alterations in single- and multi-chain proteins would lend a hand in human welfare. Unlike single-chain proteins, the function of multichain proteins depends upon the inherent properties of the subunit interfaces. The interfaces of temporary oligomeric proteins and the active sites of enzymes are of similar characteristics but the interfaces are more conservative than the active sites. Therefore, these interfaces may possibly be represented as drug targets by inhibition or induction of the oligomerization process. Thus without detailed structural understanding of ligand-induced conformational changes in a protein, structure-based rational drug designing is a great challenging task. So the purpose of this review is to clarify or enlighten the reader at the degree of internal motions related to protein backbone and side-chain flexibility which occur on binding of small molecule to a protein target. This can prove helpful to improve the conformational prediction for a protein–ligand complex. Besides a detailed description of protein–ligand interaction, this review also focuses on structure–activity relationships of protein which will surely help in the rational drug designing.
Nuclear magnetic resonance study of the interaction of T4 endonuclease V with DNA.

T4 endonuclease V catalyzes the DNA strand cleavage in the vicinity of a thymine dimer. In order to obtain insight into the specific recognition mechanism of this enzyme with a thymine photodimer within DNA, the conformations of five different DNA duplexes, [sequence: see text] with which the enzyme can interact, were studied by 1H NMR. DNA I, DNA IV, and DNA V do not contain the TT sequence or a thymine dimer and hence, are expected to bind the enzyme only in a nonspecific manner. DNA II includes a single TT sequence which does not form a thymine dimer. Only DNA III is expected to bind specifically to the enzyme through a thymine photodimer. The NMR spectra of these five DNA duplexes in the absence of the enzyme clearly show that the formation of a thymine dimer within the DNA induces only a minor distortion in the structure and that the overall structure of B-type DNA is retained. The photodimer formation is found to cause a large change in chemical shifts at the GC7 base pair, which is located at the 3'-side of the thymine dimer, accompanied by the major conformational change at the thymine dimer site. The effects of T4 endonuclease V binding on these DNA duplexes were also investigated by 1H NMR. The binding of this enzyme to DNA I, DNA IV, and DNA V causes no alteration in chemical shift values of the imino proton resonances, but the binding to DNA II induces a small downfield shift in the imino proton resonance of GC7. (ABSTRACT TRUNCATED AT 250 WORDS)
Culturability and In Situ Abundance of Pelagic Bacteria from the North Sea

ABSTRACT The culturability of abundant members of the domainBacteria in North Sea bacterioplankton was investigated by a combination of various cultivation strategies and cultivation-independent 16S rRNA-based techniques. We retrieved 16S rRNA gene (rDNA) clones from environmental DNAs and determined the in situ abundance of different groups and genera by fluorescence in situ hybridization (FISH). A culture collection of 145 strains was established by plating on oligotrophic medium. Isolates were screened by FISH, amplified ribosomal DNA restriction analysis (ARDRA), and sequencing of representative 16S rDNAs. The majority of isolates were members of the genera Pseudoalteromonas,Alteromonas, and Vibrio. Despite being readily culturable, they constituted only a minor fraction of the bacterioplankton community. They were not detected in the 16S rDNA library, and FISH indicated rare (<1% of total cell counts) occurrence as large, rRNA-rich, particle-associated bacteria. Conversely, abundant members of the Cytophaga-Flavobacteriaand gamma proteobacterial SAR86 clusters, identified by FISH as 17 to 30% and up to 10% of total cells in the North Sea bacterioplankton, respectively, were cultured rarely or not at all. Whereas SAR86-affiliated clones dominated the 16S rDNA library (44 of 53 clones), no clone affiliated to the Cytophaga-Flavobacterumcluster was retrieved. The only readily culturable abundant group of marine bacteria was related to the genus Roseobacter. The group made up 10% of the total cells in the summer, and the corresponding sequences were also present in our clone library. Rarefaction analysis of the ARDRA patterns of all of the isolates suggested that the total culturable diversity by our method was high and still not covered by the numbers of isolated strains but was almost saturated for the gamma proteobacteria. This predicts a limit to the isolation of unculturable marine bacteria, particularly the gamma-proteobacterial SAR86 cluster, as long as no new techniques for isolation are available and thus contrasts with more optimistic accounts of the culturability of marine bacterioplankton.
Protecting breast feeding from breast milk substitutes

Editor—In its submission to the Acheson inquiry on poverty and health (the findings of which are expected to be published in autumn 1998) the Royal College of Paediatrics and Child Health proposed interventions to increase the number of women breast feeding their babies. At the college’s 1998 annual general meeting Unicef accepted an invitation to set up a stand at the trade exhibition to provide information on its baby friendly initiative, which was designed to help establish breast feeding and was launched in 1991. Also at that meeting members and fellows reaffirmed their unequivocal support for the practice and promotion of breast feeding in a policy statement. This was policy states that “women should be encouraged to practice exclusive breastfeeding for the first 4-6 months of their infant’s life. Thereafter, infants should be enabled to breastfeed while receiving appropriate and adequate weaning food for as long as this meets with their mothers’ wishes and convenience. ”1 Therefore, we were surprised and disappointed to read some of the sentiments expressed in the editorial by Costello and Sachdev on encouraging breast feeding which reminded doctors that manufacturers of infant milk substitutes may attempt to seek “endorsement by association” or “passivity towards their products. ”2 They cited as examples the failure of the Royal College of Paediatrics and Child Health to join the interagency group on monitoring breast feeding and the fact that the college accepts research funds from manufacturers of breast milk substitutes. In fact, the college declined to join the group not because it was opposed to its aims but because of legitimate concerns about the proposed research methodology. The college takes the issue of commercial sponsorship seriously, not only in the area of breast milk substitutes. At the 1997 annual general meeting the college’s ethics committee was asked to investigate the marketing of breast milk substitutes and provide recommendations for action. Its report will be ready later this year. In the meantime no further research funding or donations have been or will be accepted from manufacturers of infant formula.
Inverse correlation in nutritionally variant streptococci between the production of bacteriolytic activity and sensitivity to a Streptococcus pyogenes bacteriocinlike inhibitory substance

Nineteen strains of nutritionally variant streptococci (NVS) were tested for bacteriolytic activity and for their production of and sensitivity to streptococcal bacteriocinlike inhibitory substances (BLIS). None appeared to produce BLIS. An inverse relationship was found between the sensitivity to BLIS and the production of bacteriolytic activity against Micrococcus luteus. All but one of the 14 Streptococcus defectivus isolates were sensitive to the BLIS of S. pyogenes P5, and these isolates were nonlytic. The five S. adjacens isolates were not sensitive to any BLIS tested, and all of these isolates displayed bacteriolytic activity. Sensitivity to the BLIS of S. agalactiae P3 separated the nonlytic S. defectivus strains into two categories.
Cognitive deficits associated with blood lead concentrations <10 microg/dL in US children and adolescents.

OBJECTIVE Lead is a confirmed neurotoxicant, but the lowest blood lead concentration associated with deficits in cognitive functioning and academic achievement is poorly defined. The purpose of the present study was to examine the relationship of relatively low blood lead concentrations-especially concentrations <10 micrograms per deciliter (microg/dL)--with performance on tests of cognitive functioning in a representative sample of US children and adolescents. METHODS The authors used data from the Third National Health and Nutrition Examination Survey (NHANES III), conducted from 1988 to 1994, to assess the relationship between blood lead concentration and performance on tests of arithmetic skills, reading skills, nonverbal reasoning, and short-term memory among 4,853 children ages 6-16 years. RESULTS The geometric mean blood lead concentration for children n the study sample was 1.9 microg/dL; 172 (2.1%) had blood lead concentrations > or =10 microg/dL. After adjustment for gender, race/ethnicity, poverty, region of the country, parent or caregiver's educational level, parent or caregiver's marital status parent, serum ferritin level, and serum cotinine level, the data showed an inverse relationship between blood lead concentration and scores on four measures of cognitive functioning. For every 1 microg/dL increase in blood lead concentration, there was a 0.7-point decrement in mean arithmetic scores, an approximately 1-point decrement in mean reading scores, a 0.1-point decrement in mean scores on a measure of nonverbal reasoning, and a 0.5-point decrement in mean scores on a measure of short-term memory. An inverse relationship between blood lead concentration and arithmetic and reading scores was observed for children with blood lead concentrations lower than 5.0 microg/dL. CONCLUSION Deficits in cognitive and academic skills associated with lead exposure occur at blood lead concentrations lower than 5 microg/dL.
"To Carve Nature at Its Joints": On the Existence of Discrete Classes in Personality

In principle, units of personality may be of two varieties: dimensional variables, which involve continuously distributed differences in degree, and class variables, which involve discretely distributed differences in kind. There exists, however, a prevailing and rarely questioned assumption that the units of personality are continuous dimensions and an accompanying prejudice against class variables. We examine this prejudice, the arguments that generated it, and those that uphold it. We conclude that these arguments are applicable to class variables as they often have been explicated, in phenetic terms; by contrast, genetically explicated class variables are not vulnerable to these arguments. We propose criteria for conjecturing and present methods for corroborating the existence of class variables in personality. Specifically, we test a class model of a construct whose conceptual status makes it reasonable to evaluate whether or not the differences between individuals represented by this construct constitute discrete classes. Finally, we examine the implications for conceptualizing and investigating the nature and origins of personality.