Miracle-dz/UniFAR-FTUs huggingface dataset:
Human mesenchymal stem cell loading as a novel targeting and drug delivery system for stroke.

Stroke is the second most common cause of death globally and yet there have been no new developments towards a therapy in the last 25 years. The main issue that surrounds developing therapeutic options for stroke, is the task of overcoming the blood brain barrier (BBB) and delivering an effective treatment to the brain itself. The complications of effectively delivering treatment after stroke are so monumental, that the efficiency of a new therapeutic drug is directly related to the efficiency of the delivery method. Previous methods of drug delivery such as intravenous injection have proved highly ineffective or gravely invasive for the patient. Human mesenchymal stem cells (HMSCs) provide a unique opportunity for developing a novel targeting and drug delivery system, which could effectively deliver therapeutics to specific regions of infarct following stroke. This work aimed to evaluate and quantify the potential of HMSCs to uptake and release various therapeutics, whilst also investigating whether superparamagnetic iron oxide nanoparticles (SPIOs) could be combined with a fixed magnetic field in order to facilitate HMSC migration. In order to investigate the uptake and release of therapeutics, HMSCs were primed with both fibroblast growth factor 2 (FGF-2) and a cyclin-dependent kinase 5 inhibitory peptide (p5). The uptake and release of these potential therapeutics was investigated using developed enzyme-linked immunosorbent assays, fluorescent microscopy and HPLC-MS/MS. The in vitro effects of p5 were investigated using an experimental stroke model and Western blotting. HMSCs were also primed with SPIOs, to determine whether they could be successfully internalized by the cells and if the magnetic properties of the nanoparticles could be also used to facilitate cellular migration. This was completed by using both fluorescent and bright-field microscopy, combined with a transwell migration assay. The data provided shows the potential of HMSCs both as a drug delivery method and for cellular manipulation in vitro. HMSCs have not only been shown to successfully internalize both potential therapeutics and SPIOs but that this could be directly applied to the development of new treatment options following stoke. Furthermore, these results show that the p5 peptide also provides a leading new development for targeted therapy following stroke and that it could pose a useful candidate for future studies within neurodegenerative diseases.
Köpeklerde Gözlenen Kardiak Büyümelerin Elektrokardiyografik Olarak Belirlenmesi

In this study, the electrocardiographic parameters necessary to determine cardiac enlargements and to establish and distinguish such complaints from each other in the early stage in dogs with circulatory problems were assessed. The material of the study consisted of 33 dogs 1.5-15 years of age with cardiac enlargements determined from 140 dogs suspected of having cardiac disease based on clinical, radiographic and electrocardiographic analyses. In these dogs, 12 cases of left atrial hypertrophy (LAH), 6 cases of right atrial hypertrophy (RAH), 22 cases of left ventricular hypertrophy (LVH) and 1 case of right ventricular hypertrophy (RVH) were determined. The results of electrocardiographic records showed lengthening in P wave duration in left atrial hypertrophy (0.07-0.01 mm/sec), increase in P wave amplitude in right atrial hypertrophy (0.51-0.07 mV), increase in R wave amplitude in left ventricular hypertrophy (3.07-0.57 mV), and increase in S wave amplitude in right ventricular hypertrophy (2.8 mV). In vectorcardiographic analysis, the mean electrical axis of the QRS complex was determined to be 75.83-20.16 degrees in left atrial hypertrophy, 76.5-10.43 degrees in right atrial hypertrophy, 51.76-36.29 degrees in left ventricular hypertrophy and -98 degrees in right ventricular hypertrophy. It was observed that cardiac enlargements can be easily detected via the I and aVF leads of electrocardiography. In this way, it was determined that atrial enlargements can be easily detected by increases in P wave duration or amplitudes of electrocardiography, and ventricular enlargements can be easily detected by increases in R or S waves amplitudes.
Astrocyte‐intrinsic regulation of central nervous system inflammation and neurodegeneration

Astrocytes constitute the majority of cells in the mammalian brain, where they carry out fine‐tuned tasks that include, for example, the formation of the blood–brain barrier, the provision of structural support, the regulation of ion homeostasis and neurotransmitter recycling, and the modulation of neuronal function. In the context of autoimmune inflammation in the central nervous system during multiple sclerosis, these and other functions are challenged, while astrocytes modulate the local inflammatory response not only by regulating the blood–brain barrier permeability, but also by controlling the recruitment and activation of inflammatory cells and neurotoxicity. In the present review, we discuss astrocyte‐intrinsic mechanisms that affect multiple sclerosis pathology and might provide potential targets for therapeutic intervention.
3-Nitro­benzaldehyde

Polymorph I of the title compound, C7H5NO3, is approximately planar: the dihedral angle between the benzene ring and the nitro group is 10.41 (4)° and the aldehyde O atom deviates from the ring plane by 0.165 (1) A. In the crystal, aromatic π–π stacking inter­actions are observed [centroid–centroid separation = 3.7363 (5) A].
Cosmetic Surgery: A Common and Accepted Form of Self‐Improvement?1

The pursuit of beauty through alteration of physical appearance is a growing trend. Rates of cosmetic surgery have soared, suggesting that surgery is a common, acceptable solution to the desire for self-improvement. Despite indications that surgeries are increasing in frequency, there have been few empirical investigations about popular attitudes toward cosmetic surgery. In the present study, 302 female undergraduate students were surveyed. Approximately 3% of the sample had undergone cosmetic surgery themselves, and half knew at least 1 person among their friends and family who had undergone cosmetic surgery. As hypothesized, approval and reported future likelihood of cosmetic surgery were predicted by greater media exposure, greater vicarious experience of cosmetic surgery, and greater importance of appearance to self-worth. No significant differences among ethnic groups were found.
Applicability of Criteria for V̇O2max in Active Adolescents

This study examined the applicability of criteria for maximal oxygen consumption (VO2max) in adolescents. Active females (n=38) and males (n=196) who were students at a sports-technical junior high school performed a treadmill Bruce protocol to volitional fatigue. The criteria for VO2max were R ≥1.0, HR ≥95% of predicted maximal for age, and an increase in VO2 ≤2.1 ml·kg−1·min−1 with an increase in workload. The first criterion was met by 97% of the females and 93% of the males, while 81% of the females and 75% of the males met the second criterion. Only 8% of the females and 13% of the males met the third criterion. Those who achieved a plateau showed higher HR at peak exercise compared to those who did not (204 ±7.0 vs. 200.6 ±7.2, P≤0.05). Our data indicate that a high proportion of adolescents exhibit subjective and objective indicators of maximal performance without showing a plateau in VO2. Age-specific criteria for VO2max should be developed.
Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective

This Report has a number of inter-related general purposes. One is to explore the extent to which food, nutrition, physical activity, and body composition modify the risk of cancer, and to specify which factors are most important. To the extent that environmental factors such as food, nutrition, and physical activity influence the risk of cancer, it is a preventable disease. The Report specifies recommendations based on solid evidence which, when followed, will be expected to reduce the incidence of cancer.
慢性脑供血不足患者的脑血管功能分析 Analysis of Cerebrovascular Function in Patients with Chronic Cerebral Circulation Insufficiency

目的：研究慢性脑供血不足患者的脑血管功能情况。 方法：采用CBA CV300型脑血管功能(CVHI)检测仪分别对120例慢性脑供血不足患者和60例正常对照组进行测定，分析相关指标。 结果：慢性脑供血不足(CCCI)患者，随着年龄的增长，平均血流量(Qmean)、最大流速(Vmax)、最小流速(Vmin)、平均流速(Vmean)和差压(DP)等呈显著下降趋势，外周阻力(Rv)、特性阻抗(Zcv)、脉搏波速(Wv)、动态阻力(DR)、临界压(CP)等指标呈现显著升高趋势。 CCCI患者的积分值、流速和流量等明显低于对照组，但Rv、Wv及Zcv等明显高于对照组，差异有统计学意义(P < 0.05)。 结论：慢性脑供血不足是动脉粥样硬化所致，脑血管功能受损明显，卒中发病风险增加。 Objective: To study the Cerebrovascular Function in patients with chronic cerebral circulation insufficiency (CCCI). Methods: 120 patients diagnosed as CCCI were assigned in test group, and 60 healthy people were in normal control group; they were given CBA CV300 Cerebrovascular hemodynamic indexes (CVHI) examination, and analysis of related indicators. Results: In CCCI, with the age increaing, cerebrovascular hemodynamic synthesized index, including quantity of mean blood flow (Qmean), velocity of maximum blood flow (Vmax), velocity of minimus blood flow (Vmin), velocity of mean blood flow (Vmean), pulse wave velocity (Wv), characteristic impedance (Zcv), resistance of vascular (Rv), development resistance (DR), capillary pressure (CP), pressure difference (DP). The numbers of Qmean, Vmax, Vmin, Vmean and DP appeared to obviously decline, but the numbers of Rv, Zcv, Wv, DR and CP appeared to obviously raise. The CCCI patients’ cerebrovascular hemodynamic synthesized score (CVHS), flow velocity and flow rate are significantly lower than the control group, but the Rv, Wv and Zcv, significantly higher than the control group, the difference was statistically significant. Conclusions: CCCI is the result of atherosclerosis, and Cerebrovascular function was damaged obviously, the risk of stroke is increasing.
Liquid–liquid phase separation and viscosity within secondary organic aerosol generated from diesel fuel vapors

Abstract. Information on liquid–liquid phase separation (LLPS) and viscosity (or diffusion) within secondary organic aerosol (SOA) is needed to improve predictions of particle size, mass, reactivity, and cloud nucleating properties in the atmosphere. Here we report on LLPS and viscosities within SOA generated by the photooxidation of diesel fuel vapors. Diesel fuel contains a wide range of volatile organic compounds, and SOA generated by the photooxidation of diesel fuel vapors may be a good proxy for SOA from anthropogenic emissions. In our experiments, LLPS occurred over the relative humidity (RH) range of ∼70 % to ∼100 %, resulting in an organic-rich outer phase and a water-rich inner phase. These results may have implications for predicting the cloud nucleating properties of anthropogenic SOA since the presence of an organic-rich outer phase at high-RH values can lower the supersaturation with respect to water required for cloud droplet formation. At ≤10 % RH, the viscosity was ≥1×108 Pa s, which corresponds to roughly the viscosity of tar pitch. At 38 %–50 % RH, the viscosity was in the range of 1×108 to 3×105 Pa s. These measured viscosities are consistent with predictions based on oxygen to carbon elemental ratio (O:C) and molar mass as well as predictions based on the number of carbon, hydrogen, and oxygen atoms. Based on the measured viscosities and the Stokes–Einstein relation, at ≤10 % RH diffusion coefficients of organics within diesel fuel SOA is ≤5.4×10-17 cm2 s−1 and the mixing time of organics within 200 nm diesel fuel SOA particles (τmixing) is 50 h. These small diffusion coefficients and large mixing times may be important in laboratory experiments, where SOA is often generated and studied using low-RH conditions and on timescales of minutes to hours. At 38 %–50 % RH, the calculated organic diffusion coefficients are in the range of 5.4×10-17 to 1.8×10-13 cm2 s−1 and calculated τmixing values are in the range of ∼0.01 h to ∼50 h. These values provide important constraints for the physicochemical properties of anthropogenic SOA.
A clinical study of the effect of Glycyrrhiza glabra plant and exercise on the quality of life of menopausal women

BACKGROUND: Most women experience significant changes during and after menopause which causes various complications of menopause and the changes in quality of their life. The aim of this study was to evaluate the effect of Glycyrrhiza glabra plant and exercise on quality of life (QOL) of menopausal women. METHODS: This clinical experiment was performed in Arak, Iran. The study subjects consisted of 120 menopausal women. The participants were selected through convenience method and randomly divided into 4 groups of 30 subjects. Group 1 participants were administered 3 Glycyrrhiza glabra tablets daily. Group 2 participants had a regular exercise program. Group 3 participants were simultaneously administered Glycyrrhiza glabr tablets like group 1 and had an exercise program like group 2. Group 4 received no intervention. The participants’ QOL was investigated before and 1 month after the intervention using the Menopause-Specific Quality of Life (MENQOL) Questionnaire. Data analysis was performed in SPSS software using Mann-Whitney, Wilcoxon, Kruskal-Wallis, and chi-square tests, and variance analysis. RESULTS: No significant difference between the four groups in terms of vasomotor, psychosocial, physical, and sexual health, and QOL based on the Kruskal-Wallis test before the intervention. However, a significant difference was observed between the groups in terms of vasomotor, psychosocial, physical, and sexual health and QOL after the intervention. CONCLUSION: The results of this study showed the efficacy of Glycyrrhiza glabra and exercise programs in controlling the symptoms of menopause. It is recommended that postmenopausal women use exercise programs and Glycyrrhiza glabra to control menopausal symptoms.
Taxonomic and functional exploration of the biosphere of serpentinizing hydrothermal systems by metagenomics

Les systemes hydrothermaux associes a la serpentinisation sont anoxiques et riches en $H_2$, $CH_4$ et molecules organiques. Ces composants alimentent des micro-organismes qui colonisent les systemes serpentinises, et ce en depit d’un pH eleve et de faibles concentrations en accepteurs d'electrons et en carbone dissous. Dans ce travail, les communautes microbiennes ont ete etudiees en se focalisant sur Prony, un ecosysteme serpentinise cotier de Nouvelle-Caledonie, puis, en comparant differents ecosystemes serpentinises, pour faire emerger des similarites taxonomiques et fonctionnelles. A Prony, nos analyses de metabarcoding ont mis en evidence l'importance d’une biosphere rare. L'analyse de metagenomes a permis de reconstruire 82 genomes procaryotes. Un de ces genomes est phylogenetiquement proche des especes du genre Serpentinomonas, bacteries chimiolithotrophes isolees du site serpentinise The Cedars, qui detiennent le record d’alcalophilie. Ces especes et d'autres phylotypes, tels que les taxons affilies aux Lost City Methanosarcinales, ont ete trouves dans plusieurs sites serpentinises et pourraient contribuer a la definition d'une signature biologique des phenomenes de serpentinisation. En ciblant specifiquement les metabolismes enrichis dans les milieux serpentinises, nous avons pu mettre en evidence l'importance du metabolisme de l'hydrogene, des mecanismes cellulaires de reponse aux stress et d’une voie de degradation des phosphonates, reposant sur l’activite d'une C-P lyase. Cette voie metabolique, qui a un role cle dans l'assimilation du phosphore et la liberation de molecules organiques, vient enrichir les modeles ecologiques des systemes serpentinises.
Serum Electrolytes in Cerebro-Vascular Accidents

Cerebro-vascular accidents cause significant impairments particularly in older age and are amongst the major health issues in several countries. Limited evidence is available about the association between electro- lytes and cerebro-vascular accidents in the general population. In view of this, the present study was conducted to analyse serum electrolytes in patients with cerebro-vascular accidents. 40 patients with cerebro-vascular accidents and 40 sex matched healthy controls aged 45 to 85 years were enrolled for this study and serum electrolytes were measured via standard laboratory methods. Patients with cerebro-vascular accidents had higher serum sodium and chloride levels with lower serum potassium levels compared to the controls which were statistically significant.Therefore, the findings of this study confirm the strong association between serum electrolytes and incidence of cerebro-vascular accidents. A stroke or "brain attack" occurs when a blood clot blocks the blood flow in a vessel or artery (Ischemia) or when a blood ves- sel breaks (Haemorrhage), interrupting blood flow to an area of the brain. When either of these things happens, brain cells begin to die and abilities controlled by that area of the brain are lost. "Little stroke, big trouble" the theme of the World Health Day, 2008, speaks about the importance of Stroke as a critical warn- ing sign of further more debilitating vascular events or death (3) . Due to the consequent high mortality and morbidity rates, stroke has become a major community health problem world- wide and it is the third leading cause of death and long term morbidity in developed and developing countries (4, 5) .
Evidenz-basierte Ernährungsempfehlungen zur Behandlung und Prävention des Diabetes mellitus *

Autorisierte deutsche Version: M. Toeller nach: Diabetes and Nutrition Study Group (DNSG) of the European Association for the Study of Diabetes (EASD). Mann J, De Leeuw I, Hermansen K, Riccardi G, Rivellese A, Rizkalla A, Slama G, Toeller M, Uusitupa M, Vessby B on behalf of the DNSG of the EASD Evidence-based nutritional approaches to the treatment and prevention of diabetes mellitus. Nutr Metab Cardiovasc Dis 14 (2004) 373-394 In Abstimmung mit der Deutschen Diabetes-Gesellschaft (DDG) In Abstimmung mit der Deutschen Adipositas-Gesellschaft (DAG) In Abstimmung mit der Deutschen Gesellschaft für Ernährungsmedizin (DGEM) In Abstimmung mit der Deutschen Gesellschaft für Ernährung (DGE)
A Review of Relationship between Fear Avoidance Beliefs and Postural Stability in Non Specific Chronic Low Back Pain

Introduction: Low back pain (LBP) is one of the most prevalent diseases in most developed and developing countries, affecting 70% to 80% of adults at some time during their lives. Recent evidence suggests that psychosocial factors especially fear-avoidance beliefs (FAB) are important in predicting patients who will progress from an acute to a chronic stage as well as failure of interventions. The aim of this study is to review the Relationship between Fear Avoidance Beliefs and Postural stability in non specific Chronic Low Back Pain (CLBP). Methods: In this narrative article we have searched PubMed, CINHAL, APTA and MEDLINE data bases. The key words included: chronic low back pain, fear avoidance beliefs, posture, stability, balance, motor control, center of pressure and force plate. The inclusion criteria were being related to FAB and postural stability and adults with non specific CLBP, in English language, up to 2013, regardless of their study design. Results: The results showed that psychological factors such as FAB influence the chronicity of LBP, a group of studies indicated that FAB is related to pain and disability. Another group of studies indicated that postural stability is related to pain and disability. The only study on the relationship between postural stability and FAB did not found any significant relationship. Conclusion: FAB is related to pain and disability. Postural stability is related to pain and disability. More studies with stronger methodology such as larger population with control group are needed for evaluating the relationship of FAB and postural control.
Psychosocial cancer care There is more to cancer care than medical management.

This paper briefly reviews some of the current interests in the international field of psychosocial oncology, focusing on adults with cancer. The articles cited describe cancer in general – not specific cancers. It is not possible to give a comprehensive literature review on such a wide and dynamic field of care, but what follows may serve as an introduction, hopefully stimulating awareness of the many aspects of psychosocial cancer care.
K(MoO2)4O3(AsO4)

A new compound with a non-centrosymmetric structure, potassium tetrakis[dioxomolybdenum(IV)] arsenate trioxide, K(MoO2)4O3(AsO4), has been synthesized by a solid-state reaction. The [(MoO2)4O3(AsO4)]+ three-dimensional framework consists of single arsenate AsO4 tetrahedra, MoO6 octahedra, MoO5 bipyramids and bioctahedral units of edge-sharing Mo2O10 octahedra. The [Mo2O8]∞ octahedral chains running along the a-axis direction are connected through their corners to the AsO4 tetrahedra, MoO6 octahedra and MoO5 bipyramids, so as to form large tunnels propagating along the a axis in which the K+ cations are located. This structure is compared with compounds containing M 2O10 (M = Mo, V, Fe) dimers and with those containing M 2O8 (M = V) chains.
Psoriasis

Psoriasis is an immune-mediated inflammatory cutaneous disorder characterized by chronic, scaling, erythematous patches and plaques of skin. It can begin at any age and can vary in severity. Psoriasis can manifest itself in several different forms, including pustular and erythrodermic forms. In addition to involving the skin, psoriasis frequently involves the nails, and some patients may experience inflammation of the joints (psoriatic arthritis). Because of its highly visible nature, psoriasis can compromise both the personal and the working lives of its victims. Breakthroughs in the treatment of psoriasis have led to a better understanding of its pathogenesis. This review contains 12 figures, 8 tables, and 79 references. Keywords: Psoriases, Pustulosis of Palms and Soles, Pustulosis Palmaris et Plantaris, Palmoplantaris Pustulosis, Pustular Psoriasis of Palms and Soles
A Spectacularly Spotted Star

AGES: 14–17 Stars like the Sun have dark spots on their surfaces. These dark spots are important for astronomers, because they allow us to track how quickly a star is spinning, which is related to the age of a star. Since Earth is close to the Sun, spots on the Sun are easy to see, but for distant stars, our telescopes are not powerful enough to see starspots. That iswhy astronomers have begun to use planets to study starspots.When aplanet eclipses its star, the amount of light that goes missing depends onwhether the planet is blocking out a bright part of the star or a dim part of the star, like a starspot. Using this technique, astronomers have determined that HAT-P-11, a star 20% less massive than the Sun, has spots just like the Sun, but its surface is 100 times more spotted than the Sun’s.
The Role of Myocardial Mitochondrial Quality Control in Heart Failure

At present, the treatment of heart failure has entered the plateau phase, and it is necessary to thoroughly study the pathogenesis of heart failure and find out the corresponding treatment methods. Myocardial mitochondria is the main site of cardiac energy metabolism, whose dysfunction is an important factor leading to cardiac dysfunction and heart failure. Mitochondria are highly dynamic organelles. Continuous biogenesis, fusion, fission and mitophagy, contribute to the balance of mitochondria's morphology, quantity, and quality, which is called mitochondrial quality control. Mitochondrial quality control is the cornerstone of normal mitochondrial function and is found to play an important role in the pathological process of heart failure. Here, we provide an overview of the mechanisms of mitochondrial quality control and recent studies on mitochondrial quality control in heart failure, hoping to provide new ideas for drug development in heart failure.