Miracle-dz/UniFAR-FTUs huggingface dataset:
Broadening End-of-Life Comfort to Improve Palliative Care Practices in Long Term Care

RÉSUMÉ Cette étude qualitative canadienne rapporte les résultats de 19 groupes de discussion comprenant 117 participants, incluant des bénéficiaires, des familles et des membres du personnel. Elle avait pour objectifs : 1) d’explorer les soins palliatifs offerts en soins de longue durée (SLD) en vue de faire face aux tensions associées à la prestation de soins aux personnes qui sont encore bien vivantes et celles en fin de vie dans une même communauté de soins et 2) d’identifier des améliorations qui pourraient être apportées aux pratiques en soins palliatifs afin de mieux répondre aux besoins de tous les bénéficiaires en vie ou mourants dans les établissements de SLD, ainsi que celles des familles et du personnel qui leur apportent du soutien. Notre étude a montré que les perspectives liées au confort en fin de vie du personnel en SLD, celles des bénéficiaires et de leurs familles étaient appliquaient à ceux qui se trouvaient en fin de vie ou aux familles qui les soutenaient. Cette compréhension du confort limitait l’intégration des principes de soins palliatifs lors des derniers jours de vie des bénéficiaires. Les résultats de notre étude ont aussi suggéré que le fait de recueillir les perceptions des bénéficiaires liées au confort en fin de vie, de partager l’information à propos de la mort d’un bénéficiaire d’une manière plus personnelle, et de s’assurer que les bénéficiaires, leurs familles et le personnel aient des occasions de participer dans les soins de confort pour les bénéficiaires mourants pouvaient accroître le confort en fin de vie et soutenir une plus grande intégration des principes de soins palliatifs en SLD. ABSTRACT This study aimed to (1) explore how palliative care in long-term care (LTC) addresses the tensions associated with caring for the living and dying within one care community, and (2) to inform how palliative care practices may be improved to better address the needs of all residents living and dying in LTC as well as those of the families and support staff. This article reports findings from 19 focus groups and 117 participants. Study findings reveal that LTC home staff, resident, and family perspectives of end-of-life comfort applied to those who were actively dying and to their families. Our findings further suggest that eliciting residents’ perceptions of end-of-life comfort, sharing information about a fellow resident’s death more personally, and ensuring that residents, families, and staff can constructively participate in providing comfort care to dying residents could extend the purview of end-of-life comfort and support expanded integration of palliative principles within LTC.
A temporal study of axonal degeneration and glial scar formation following a standardized crush injury of the optic nerve in the adult rat.

PURPOSE In this methodological study, we describe a standardized optic nerve injury model in adult rats. The temporal pattern of the glial response is mapped in relation to axonal regeneration and degeneration. METHODS A standardized optic nerve crush injury was made in adult rats, using a fine pair of forceps with a preset pressure of 0.6 N during 10 seconds. RESULTS This crush injury resulted in a pronounced astroglial and microglial proliferation 2-7 dpi. Degenerative axons distal to the lesion presented a gradual decrease in neurofilament immunoreactivity. In contrast, Fluoro-Jade staining was gradually increased in these degenerative axons from 2-7 dpi. Regeneration was observed proximal to the lesion in sprouts double labeled with the tracer Fluoro-Gold and anti-GAP43. CONCLUSION The standardized optic nerve crush injury model used in the present study resulted in a reproducible degenerative pattern including a pronounced astroglial and microglial proliferation. The gradual decrease in Neurofilament immunoreactivity in degenerative axons, and a gradual increase in Fluoro-Jade staining was paralleled with a spontaneous regeneration proximal to the lesion, shown with tracing and GAP43-immunoreactivity. The combination of these markers and this experimental setup thus allows analysis of the entire degenerative/regenerative process in a standardized CNS axotomy model.
Robust and efficient intrusion detection systems

INTRUSION Detection systems are now an essential component in the overall network and data security arsenal. With the rapid advancement in the network technologies including higher bandwidths and ease of connectivity of wireless and mobile devices, the focus of intrusion detection has shifted from simple signature matching approaches to detecting attacks based on analyzing contextual information which may be specific to individual networks and applications. As a result, anomaly and hybrid intrusion detection approaches have gained significance. However, present anomaly and hybrid detection approaches suffer from three major setbacks; limited attack detection coverage, large number of false alarms and inefficiency in operation. In this thesis, we address these three issues by introducing efficient intrusion detection frameworks and models which are effective in detecting a wide variety of attacks and which result in very few false alarms. Additionally, using our approach, attacks can not only be accurately detected but can also be identified which helps to initiate effective intrusion response mechanisms in real-time. Experimental results performed on the benchmark KDD 1999 data set and two additional data sets collected locally confirm that layered conditional random fields are particularly well suited to detect attacks at the network level and user session modeling using conditional random fields can effectively detect attacks at the application level. We first introduce the layered framework with conditional random fields as the core intrusion detector. Layered conditional random field can be used to build scalable and efficient network intrusion detection systems which are highly accurate in attack detection. We show that our systems can operate either at the network level or at the application level and perform better than other well known approaches for intrusion detection. Experimental results further demonstrate that our system is robust to noise in training data and handles noise better than other systems such as the decision trees and the naive Bayes. We then introduce our unified logging framework for audit data collection and perform user session modeling using conditional random fields to build
Algoritmo de inserción de pausas para una lengua declinada

Text to speech synthesis systems must have a module to insert breaks that are not indicated in the text. In this paper an algorithm to insert breaks for standard Basque is developed. This algorithm uses morphology, syntax and information about the grammatical case. The algorithm has been evaluated both objectively and subjectively and the results confirm that this kind of information is suitable to make the prediction of the location of the breaks in standard Basque. All three types of information contribute to the improvements of the results of the algorithm.
Molecular profiling of tumour budding implicates TGFβ‐mediated epithelial–mesenchymal transition as a therapeutic target in oral squamous cell carcinoma

Although tumour budding is an adverse prognostic factor for many cancer types, the molecular mechanisms governing this phenomenon are incompletely understood. Therefore, understanding the molecular basis of tumour budding may provide new therapeutic and diagnostic options. We employ digital image analysis to demonstrate that the number of tumour buds in cytokeratin‐stained sections correlates with patients having lymph node metastases at diagnosis. The tumour bud count was also a predictor of overall survival, independent of TNM stage. Tumour buds and paired central tumour areas were subsequently collected from oral squamous cell carcinoma (OSCC) specimens, using laser capture microdissection, and examined with RNA sequencing and miRNA‐qPCR arrays. Compared with cells from the central parts of the tumours, budding cells exhibited a particular gene expression signature, comprising factors involved in epithelial–mesenchymal transition (EMT) and activated TGFβ signalling. Transcription factors ZEB1 and PRRX1 were up‐regulated concomitantly with the decreased expression of mesenchymal–epithelial (MET) transcription factors (eg OVOL1) in addition to Krüppel‐like factors and Grainyhead‐like factors. Moreover, miR‐200 family members were down‐regulated in budding tumour cells. We used immunohistochemistry to validate five markers of the EMT/MET process in 199 OSCC tumours, as well as in situ hybridization in 20 OSCC samples. Given the strong relationship between tumour budding and the development of lymph node metastases and an adverse prognosis, therapeutics based on inhibiting the activation of TGFβ signalling may prove useful in the treatment of OSCC. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Force and Velocity of Mycoplasma mobile Gliding

ABSTRACT The effects of temperature and force on the gliding speed of Mycoplasma mobile were examined. Gliding speed increased linearly as a function of temperature from 0.46 μm/s at 11.5°C to 4.0 μm/s at 36.5°C. A polystyrene bead was attached to the tail of M. mobile using a polyclonal antibody raised against whole M. mobile cells. Cells attached to beads glided at the same speed as cells without beads. When liquid flow was applied in a flow chamber, cells reoriented and moved upstream with reduced speeds. Forces generated by cells at various gliding speeds were calculated by multiplying their estimated frictional drag coefficients with their velocities relative to the liquid. The gliding speed decreased linearly with force. At zero speed, the force measurements extrapolated to 26 pN at 22.5 and 27.5°C. At zero force, the speed extrapolated to 2.3 and 3.3 μm/s at 22.5 and 27.5°C, respectively—the same speeds as those observed for free gliding cells. Cells attached to beads were also trapped by an optical tweezer, and the stall force was measured to be 26 to 28 pN (17.5 to 27.5°C). The gliding speed depended on temperature, but the maximum force did not, suggesting that the mechanism is composed of at least two steps, one that generates force and another that allows displacement. Other implications of these results are discussed.
Remédios em atos de concentração: teoria e prática do CADE

O artigo apresentar as principais recomendacoes encontradas na literatura acerca do desenho de implementacao de remedios em atos de concentracao e, sempre que possivel, tracar um paralelo entre tais recomendacoes e a pratica do CADE no periodo entre 1995 e 2013. A metodologia empregada foi a analise descritiva de dados secundarios, obtidos por meio de pesquisa no sitio eletronico do CADE, especificamente atas de sessoes de julgamento do CADE, Relatorios Anuais do orgao e Termos de Compromisso de Desempenho – TCDs/Acordos em Controle de Concentracao - ACCs.
Phosphorus Dynamics: From Soil to Plant1

With increasing demand of agricultural production and as the peak in global production will occur in the next decades, phosphorus (P) is receiving more attention as a nonrenewable resource ([Cordell et al., 2009][1]; [Gilbert, 2009][2]). One unique characteristic of P is its low availability due to
Behavioral tagging is a general mechanism of long-term memory formation

In daily life, memories are intertwined events. Little is known about the mechanisms involved in their interactions. Using two hippocampus-dependent (spatial object recognition and contextual fear conditioning) and one hippocampus-independent (conditioned taste aversion) learning tasks, we show that in rats subjected to weak training protocols that induce solely short term memory (STM), long term memory (LTM) is promoted and formed only if training sessions took place in contingence with a novel, but not familiar, experience occurring during a critical time window around training. This process requires newly synthesized proteins induced by novelty and reveals a general mechanism of LTM formation that begins with the setting of a “learning tag” established by a weak training. These findings represent the first comprehensive set of evidences indicating the existence of a behavioral tagging process that in analogy to the synaptic tagging and capture process, need the creation of a transient, protein synthesis-independent, and input specific tag.
Two Distinct Processes of Bone-like Tissue Formation by Dental Pulp Cells after Tooth Transplantation

Dental pulp is involved in the formation of bone-like tissue in response to external stimuli. However, the origin of osteoblast-like cells constructing this tissue and the mechanism of their induction remain unknown. We therefore evaluated pulp mineralization induced by transplantation of a green fluorescent protein (GFP)–labeled tooth into a GFP-negative hypodermis of host rats. Five days after the transplantation, the upper pulp cavity became necrotic; however, cell-rich hard tissue was observed adjacent to dentin at the root apex. At 10 days, woven bone-like tissue was formed apart from the dentin in the upper pulp. After 20 days, these hard tissues expanded and became histologically similar to bone. GFP immunoreactivity was detected in the hard tissue-forming cells within the root apex as well as in the upper pulp. Furthermore, immunohistochemical observation of α–smooth muscle actin, a marker for undifferentiated cells, showed a positive reaction in cells surrounding this bone-like tissue within the upper pulp but not in those within the root apex. Immunoreactivities of Smad4, Runx2, and Osterix were detected in the hard tissue-forming cells within both areas. These results collectively suggest that the dental pulp contains various types of osteoblast progenitors and that these cells might thus induce bone-like tissue in severely injured pulp.
Desenvolvimento de compósitos cimentícios avançados à base de pós-reativos com misturas híbridas de fibras e reduzido impacto ambiental

O desenvolvimento de novos concretos vem sendo ampliado ao longo dos anos, o que ocorre paralelamente ao aprimoramento dos calculos estruturais e ao maior conhecimento sobre as propriedades dos materiais, o que conduz os projetistas ao desenvolvimento de estruturas que necessitam ter caracteristicas especificas. Com isso surge a necessidade de se desenvolver concretos especiais, que apresentam elevada resistencia mecânica e durabilidade. O concreto de pos reativos, tambem chamado de CPR, e um exemplo destes materiais. Trata-se de um concreto de ultra alto desempenho, com elevada resistencia mecânica, extremamente ductil e de baixa porosidade. Este tipo de concreto apresenta propriedades mecânicas superiores em comparacao aos concretos de alta resistencia, chegando a resistencias a compressao de 200 MPa, a tracao de 45MPa e modulo de elasticidade superior a 50 GPa. O consumo de cimento neste tipo de concreto pode atingir 800 kg/m3, alem de incorporar elevado volume de silica ativa. A otimizacao granular dos constituintes, realizada atraves de metodos de empacotamento de particulas, faz com que seja possivel obter um material com o minimo de vazios e elevada densidade. As fibras introduzidas no composto proporcionam elevada ductilidade. Neste trabalho, parte do cimento Portland foi substituido por cinza volante, para desenvolver um CPR com baixo consumo de aglomerantes. Tambem foi estudada a incorporacao de dois tipos de fibras, ou hibridizacao, para uma matriz de CPR com menor consumo de cimento. A introducao de dois tipos distintos de fibras proporciona ao material maior sinergia, diminuindo a formacao e a propagacao de fissuras durante o carregamento. Os resultados obtidos nesta pesquisa mostram que a substituicao parcial do cimento por cinza volante apresentou melhor desempenho mecânico, atingindo resistencia a compressao de aproximadamente 190 MPa com 30% de adicao. A incorporacao de dois tipos distintos de fibras, aco e polipropileno em teores de 80% e 20% respectivamente, proporcionou ao material elevada resistencia a tracao na flexao e tenacidade. Portanto, e possivel dosar CPR com menores consumos de cimento e uso de dois tipos de fibras, melhorando as propriedades da mistura e obtendo um composito com reduzido impacto ambiental.
Cesarean delivery is associated with an increased risk of obesity in adulthood in a Brazilian birth cohort study.

BACKGROUND Obesity is epidemic worldwide, and increases in cesarean delivery rates have occurred in parallel. OBJECTIVE This study aimed to determine whether cesarean delivery is a risk factor for obesity in adulthood in a birth cohort of Brazilian subjects. DESIGN We initiated a birth cohort study in Ribeirão Preto, southeastern Brazil, in 1978. A randomly selected sample of 2057 subjects from the original cohort was reassessed in 2002-2004. Type of delivery, birth weight, maternal smoking, and schooling were obtained after birth. The following data from subjects were collected at 23-25 y of age: body mass index (BMI; in kg/m(2)), physical activity, smoking, and income. Obesity was defined as a BMI ≥30. A Poisson multivariable model was performed to determine the association between cesarean delivery and BMI. RESULTS The obesity rate in adults born by cesarean delivery was 15.2% and in those born by vaginal delivery was 10.4% (P = 0.002). Adults born by cesarean delivery had an increased risk (prevalence ratio: 1.58; 95% CI: 1.23, 2.02) of obesity at adulthood after adjustments. CONCLUSION We hypothesize that increasing rates of cesarean delivery may play a role in the obesity epidemic worldwide.
Families of Hospitalized Adolescents: Sex Differences

The hospitalized adolescent's family milieu constitutes a large part of his pre-hospital environment. 27 boys and 12 girls in a state mental hospital and their parents were given a structured interview. Although the boys' behavior was more overt, the girls had a home environment marked by stricter rules, more parent-adolescent antagonism, less communication and a greater family stress.
Sex Estimation in Forensic Anthropology: Skull Versus Postcranial Elements

Abstract: When the pelvis is unavailable, the skull is widely considered the second best indicator of sex. The goals of this research are to provide an objective hierarchy of sexing effectiveness of cranial and postcranial elements and to test the widespread notion that the skull is superior to postcranial bones. We constructed both univariate and multivariate discriminant models using data from the Forensic Anthropology Data Bank. Discriminating effectiveness was assessed by cross‐validated classification, and in the case of multivariate models, Mahalanobis D2. The results clearly indicate that most postcranial elements outperform the skull in estimating sex. It is possible to correctly sex 88–90% of individuals with joint size, up to 94% with multivariate models of the postcranial bones. The best models for the cranium do not exceed 90%. We conclude that postcranial elements are to be preferred to the cranium for estimating sex when the pelvis is unavailable.
p53 and Ceramide as Collaborators in the Stress Response

The sphingolipid ceramide mediates various cellular processes in response to several extracellular stimuli. Some genotoxic stresses are able to induce p53-dependent ceramide accumulation leading to cell death. However, in other cases, in the absence of the tumor suppressor protein p53, apoptosis proceeds partly due to the activity of this “tumor suppressor lipid”, ceramide. In the current review, we describe ceramide and its roles in signaling pathways such as cell cycle arrest, hypoxia, hyperoxia, cell death, and cancer. In a specific manner, we are elaborating on the role of ceramide in mitochondrial apoptotic cell death signaling. Furthermore, after highlighting the role and mechanism of action of p53 in apoptosis, we review the association of ceramide and p53 with respect to apoptosis. Strikingly, the hypothesis for a direct interaction between ceramide and p53 is less favored. Recent data suggest that ceramide can act either upstream or downstream of p53 protein through posttranscriptional regulation or through many potential mediators, respectively.
An analysis of the frequency-temperature relations of SC-cut quartz crystal plates with the Lee plate theory

The analysis of high frequency vibrations of piezoelectric crystal plates at the thickness-shear modes are of great importance in resonator design. In addition to fundamental issues like the vibration frequency, practical needs on the effects of complication factors such as the electrodes and temperature fluctuation are also required to be available for the optimal selection of structural parameters. With the modified Lee plate equations and thermal field considered, the frequency-temperature relations which are essential in the quartz crystal resonator development have been investigated. As we have found, the frequency change from the Lee plate theory in the operation range of a quartz crystal resonator is consistent with predications of Mindlin plate theory. We now are able to design resonators with the choice of Mindlin or Lee plate equations based on individual choices.
Metapher und Gleichnis. Bemerkungen zur Reichweite des Bildes in religiöser Sprache

La modernite exige un langage religieux et une pensee religieuse qui gardent l'aspect terrestre du monde et montrent un usage raisonnable de la Parole de Dieu. La metaphore, et surtout la metaphore theologique qui lie le monde et Dieu, et ses consequences hermeneutiques ont retenu l'attention dans les differentes disciplines de la theologie. Exemple de l'allegorie Marc 4,26-29 (Royaume de Dieu et realite du monde)
Treatment of Chronic Progressive Multiple Sclerosis with Intravenous Immunoglobulins - interim Results on Drug Safety of an Ongoing Study

In a blinded administrative look we analyzed the safety profile of intravenous immunoglobulin (IVIG) treatment in an ongoing randomized, placebo controlled double blind study on the treatment of multiple sclerosis (MS) patients with primary or secondary chronic progressive MS. Up to October 1999 131 patients were included in the study. Collectively, these patients received approximately 1200 infusions either with IVIG (400 mg/kg bodyweight every 4 weeks) or with placebo; approximately 600 IVIG infusions were administered. All reported serious adverse events (SAE), including reports on adverse events submitted directly to the drug safety department of the sponsor, were closely analyzed. A total of 25 SAE's (in 25 patients) have been reported up until 15th October 1999, whereby the main criterion for ‘serious’ in all of these cases was hospitalization. None of these 25 SAE were regarded as drug related. No side effects relating to liver functions, kidney functions or rheological problems have been reported. Since the mean score on the EDSS-scale of the patients at the point of inclusion in the study was 5.6 (median EDSS: 6.0) we conclude that IVIG treatment, at a dose of 400 mg/kg bodyweight every 4 weeks, is a relatively safe therapy even for severely disabled multiple sclerosis patients.
Planeación y ejecución de trayectorias en el espacio de trabajo para un robot Delta

En este articulo se expone una tecnica de planeacion y ejecucion de trayectorias en el espacio cartesiano para ser aplicada en un robot delta. Con el fin de configurar y generar la trayectoria deseada, se disena un software con interfaz grafica (GUI), en el cual se implementa el algoritmo para calcular y visualizar los puntos intermedios de movimiento del robot en el espacio de trabajo. Para validar la trayectoria generada es utilizado un robot delta, disenado y construido en el laboratorio de Robotica de la Universidad Militar Nueva Granada, el cual es controlado por medio de un circuito electronico que permite la implementacion adecuada de la tecnica propuesta. De esta manera, es posible validar sobre el robot real las trayectorias calculadas por el algoritmo y visualizadas con el software de simulacion.