Miracle-dz/UniFAR-FTUs huggingface dataset:
Context independent properties in deliberation protocols

Multiagent systems provide a natural, intuitive model for a wide array of real world problems, where possibly heterogeneous components strive towards a common goal. Under the multiagent approach, these components can be implemented as independent agents. This ample flexibility has swayed a number of developers into adopting this scheme when dealing with industrial scale problems. On many of these systems, one can observe an striking phenomenon: the system as a whole is able to reach objectives beyond the individual capabilities of its members. For instance, suppose there are two roommates, and depict a large desk heavy enough to make changing its location an impossible task for either of them. However, the desk can be easily moved if they agree to coordinate their effort. This simple example underscores the important role of the interaction among agents in these systems. This interaction, when conducted in an orderly fashion, increases the potential of the system as a whole. The literature also emphasizes the role of the interaction, since a great deal of attention has been devoted to developing formal models for it. For instance, the theory of speech acts [4], initially conceived as a formal model of human interaction has also been adapted as a model of agent communication. More recently, the development of agent communication languages [11] such as KQML or FIPA-ACL evidences a keen interest on the subject. Finally, other researchers have aimed their work towards particular kinds of interactions, such as multiagent collaboration, negotiation, decision making, or task delegation and supervision among others. Despite all this effort, no consensus has been reached when it comes to choosing a model for a given situation: many are applicable only when certain strict conditions are met, or when huge responsibilities rest upon the knowledge engineer, such as making most of the critical decisions beforehand. Nowadays, the interest in analyzing the interaction among agents is still intact, always willing to explore new possibilities. For example, a new approach has been unveiled during the past decade, reinterpreting agent interaction as if it were the result of an argumentation process. Many promising formalisms were developed under this conception, such as the negotiation protocol of Parsons et al. [2], or the work on dispute protocols of Prakken [3], that follows the
Impact of III–V and Ge Devices on Circuit Performance

III-V and germanium (Ge) field-effect transistors (FETs) have been studied as candidates for post Si CMOS. In this paper, the performance of various digital blocks and static random access memory (SRAM) with different combinations of Si, III-V and Ge devices are studied. SPICE-compatible III-V n-channel FET (nFET) and Ge p-channel FET (pFET) models are developed for the analysis. The delay and energy of the different combinations are estimated and compared. In typical digital design, the driving capability of the nFET and pFET should be matched for optimum noise margin and performance. The combination of III-V nFET with low input capacitance and Ge pFET achieves the best energy-delay performance for many digital logic circuits. The read margin of SRAM is maximized with a Si pass-gate, and an inverter of III-V nFET and Ge pFET.
Lung transcriptional profiling: insights into the mechanisms of ozone-induced pulmonary injury in Wistar Kyoto rats

Abstract Acute ozone-induced pulmonary injury and inflammation are well characterized in rats; however, mechanistic understanding of the pathways involved is limited. We hypothesized that acute exposure of healthy rats to ozone will cause transcriptional alterations, and comprehensive analysis of these changes will allow us to better understand the mechanism of pulmonary injury and inflammation. Male Wistar Kyoto rats (10–12 week) were exposed to air, or ozone (0.25, 0.5 or 1.0 ppm) for 4 h and pulmonary injury and inflammation were assessed at 0-h or 20-h (n = 8/group). Lung gene expression profiling was assessed at 0-h (air and 1.0 ppm ozone, n = 3–4/group). At 20-h bronchoalveolar lavage, fluid protein and neutrophils increased at 1 ppm ozone. Numerous genes involved in acute inflammatory response were up-regulated along with changes in genes involved in cell adhesion and migration, steroid metabolism, apoptosis, cell cycle control and cell growth. A number of NRF2 target genes were also induced after ozone exposure. Based on expression changes, Rela, SP1 and TP3-mediated signaling were identified to be mediating downstream changes. Remarkable changes in the processes of endocytosis provide the insight that ozone-induced lung injury and inflammation are likely initiated by changes in cell membrane components and receptors likely from oxidatively modified lung lining lipids and proteins. In conclusion, ozone-induced injury and inflammation are preceded by changes in gene targets for cell adhesion/migration, apoptosis, cell cycle control and growth regulated by Rela, SP1 and TP53, likely mediated by the process of endocytosis and altered steroid receptor signaling.
“A View from Old Age’: Women’s Lives as Narrated Through Objects

ABSTRACT This article uses interview data gathered during a collaborative cross-disciplinary project undertaken in 2016 to explore experiences of longevity in qualitative detail with a small cohort of Northern Irish participants. The project was inspired by Penelope Lively’s autobiography Ammonites and Leaping Fish: A Life in Time (2013, 4, 199), which documents the author’s feelings about her life through focused reflections on her own possessions. Lively chose objects which she felt “oddly identified” her life and proposed that “people’s possessions speak of them”. We devised a series of activities to be undertaken with participants over the age of 60, with the intention of using material things as a lens on longevity. In this article we use interview data with three female participants to analyse women’s narration of their own biographies. The aim of this article is to explore the role of the possessions in narrating women’s lives and to consider how themes of ageing, memory, relationships, and the self are articulated through objects. The theoretical context for this exploratory work refers to cultural gerontology, material culture studies, gender studies and scholarship on life history. We conclude that objects offer a useful, tangible means of articulating and communicating the complexity of women’s longevity.
Photoneutron cross sections for 14C.

The photoneutron cross sections for /sup 14/C (sigma(.gamma.,1n) and sigma(.gamma.,2n)) have been measured up to 36 MeV using monochromatic photons. The cross section for the emission of a single neutron displays a very prominent resonance near 15 MeV which appears to decay primarily to the ground state of /sup 13/C. The (.gamma.,2n) cross section is sharply peaked at 26 MeV and is large compared with those for /sup 12/C and /sup 13/C. The integrated total photoneutron cross section up to 36 MeV is 126 +- 12 MeV mb (61% of the Thomas-Reiche-Kuhn sum-rule value). The /sup 14/C photoneutron cross sections are interpreted in terms of the reaction kinematics and the competition among the particle channels in order to provide information on the isospin properties of the major E1 states in /sup 14/C and on the validity of the weak core-coupling model.
The Current Status of Urban‐rural Differences in Psychiatric Disorder: An Emerging Trend for Depression

Evidence for differences in rates of psychiatric disorder by size of community is examined. Epidemiological studies reporting rates for specific diagnoses (treated and untreated) as well as those making only global assessments of psychiatric caseness are examined. An interesting trend toward higher rates of depressive disorders (excluding manic-depressive psychosis) in urban areas emerges. Differences in the availability of social support in communities of varying size is proposed as a possible explanation for this finding.
Österreichische Großmachtbildung und Reichsverfassung

Die Stellung des habsburgischen Kaisertums nach 1648 wird widersprüchlich definiert, ganz im Gegensatz zur vielfach gefeierten doppelten Großmachtbildung Österreichs und — etwas retardiert — Brandenburg-Preußens. Bis vor kurzem haben deutsche und österreichische Historiker vom Niedergang der kaiserlichen Stellung nach 1648 gesprochen). Diese Aussage wird natürlich überlagert von den Hypotheken ,^er Vergangenheit. Die These vom Niedergang des Reiches entsprach dem Klischee kleindeutsch-borussischer Historiker. Aber auch die österreichische Perspektive ließ vor der eigenen Großmachtwerdung den Reichsverband verblassen — das moderne Prinzip habe über das ältere gesiegt, ganz abgesehen von den Wunden von 1866 bis 1938. Die historische Entwicklung der letzten Jahrzehnte aber hat auch nationale Bewegungen, Machtstaat und Anstaltsstaat als Maßstäbe historischer Entwicklung erheblich relativiert. Zugleich öffneten sich für die Historiker die Perspektiven auf breite Dimensionen der Gesellschaft als Gesamtkonfiguration). All diese Entwicklungen waren günstig für eine
Nuclear envelope proteomics: Novel integral membrane proteins of the inner nuclear membrane

The nuclear envelope (NE) is one of the least characterized structures of eukaryotic cells. The study of its functional roles is hampered by the small number of proteins known to be specifically located to it. Here, we present a comprehensive characterization of the NE proteome. We applied different fractionation procedures and isolated protein subsets derived from distinct NE compartments. We identified 148 different proteins by 16-benzyl dimethyl hexadecyl ammonium chloride (16-BAC) gel electrophoresis and matrix-assisted laser desorption ionization (MALDI) mass spectrometry; among them were 19 previously unknown or noncharacterized. The identification of known proteins in particular NE fractions enabled us to assign novel proteins to NE substructures. Thus, our subcellular proteomics approach retains the screening character of classical proteomic studies, but also allows a number of predictions about subcellular localization and interactions of previously noncharacterized proteins. We demonstrate this result by showing that two novel transmembrane proteins, a 100-kDa protein with similarity to Caenorhabditis elegans Unc-84A and an unrelated 45-kDa protein we named LUMA, reside in the inner nuclear membrane and likely interact with the nuclear lamina. The utility of our approach is not restricted to the investigation of the NE. Our approach should be applicable to the analysis of other complex membrane structures of the cell as well.
Naturally occurring aminoacyl-tRNA synthetases editing-domain mutations that cause mistranslation in Mycoplasma parasites

Mycoplasma parasites escape host immune responses via mechanisms that depend on remarkable phenotypic plasticity. Identification of these mechanisms is of great current interest. The aminoacyl-tRNA synthetases (AARSs) attach amino acids to their cognate tRNAs, but occasionally make errors that substitute closely similar amino acids. AARS editing pathways clear errors to avoid mistranslation during protein synthesis. We show here that AARSs in Mycoplasma parasites have point mutations and deletions in their respective editing domains. The deleterious effect on editing was confirmed with a specific example studied in vitro. In vivo mistranslation was determined by mass spectrometric analysis of proteins produced in the parasite. These mistranslations are uniform cases where the predicted closely similar amino acid replaced the correct one. Thus, natural AARS editing-domain mutations in Mycoplasma parasites cause mistranslation. We raise the possibility that these mutations evolved as a mechanism for antigen diversity to escape host defense systems.
A model and algorithm for out-sourcing planning

This paper addresses a dynamic lot-sizing model with outsourcing. All the unsatisfied demands are out-sourced without backlogging, where the inventory capacity is limited and shortages are prohibited. Costs are concave and time varying. Some new properties are obtained in an optimal solution and a dynamic programming algorithm is developed to solve the problem in strongly polynomial time
Prise en charge des chocs hémorragiques et place de la transfusion de concentrés de globules rouges en médecine pré-hospitalière : analyse des pratiques au SMUR du CHU de Bordeaux

Introduction : La prise en charge du choc hemorragique en medecine pre-hospitaliere reste heterogene, ce malgre des recommandations regulierement actualisees. D’autre part, de nombreuses etudes posent la question de la pertinence de la transfusion pre-hospitaliere de concentre(s) de globules rouges (CGR), et de ses indications. L’objectif principal de cette etude est de faire une analyse des pratiques au sein des equipes du service mobile d’urgence et de reanimation (SMUR) du centre hospitalo-universitaire de Bordeaux, concernant la prise en charge des chocs hemorragiques lorsque les patients etaient transfuses. Materiels et methodes : Nous avons mene une etude observationnelle descriptive retrospective. Durant la periode de janvier a decembre 2015, les patients pour lesquels le diagnostic de choc hemorragique a ete retenu et ayant recu la transfusion d’au moins un CGR etaient inclus de facon consecutive. Nous avons analyse les parametres cliniques, ainsi que les modalites de la prise en charge, en effectuant une analyse en sous-groupes selon la gravite initiale. Resultats : Sur la periode d’un an, 48 patients ont ete inclus. L’âge moyen des patients etait de 55 ans et l’etiologie la plus frequemment retrouvee etait une hemorragie digestive haute prise en charge a domicile. L’analyse de la prise en charge revelait qu’en fin d’intervention le patient perdait 1,5 g/dL d’hemoglobine, que le nombre median de CGR transfuses etait de 2 [2–3] sans etre guide par la gravite initiale. D’autre part, la pression arterielle systolique (PAS) mediane finale etait de 110 mmHg [86,75–120]. Conclusion : L’analyse des pratiques a permis d’identifier des axes d’amelioration quant a la prise en charge pre-hospitaliere du choc hemorragique. L’ecriture pluridisciplinaire d’un protocole serait necessaire. Une etude comparant les patients transfuses a ceux non transfuses permettrait d’apporter des arguments supplementaires quant a la place de la transfusion pre-hospitaliere de CGR.
Staff Nurse Perceptions of the Magnet® Journey

OBJECTIVE: The objective of this study was to compile a rich description of the phenomenon Magnet® journey by registered nurses in clinical settings who provide direct patient care in community healthcare systems recently receiving Magnet designation. BACKGROUND: Evidence supports that Magnet designation leads to improved nursing, patient, and organizational outcomes. Descriptions abound regarding the organizational and cultural transformation during the time leading up to the Magnet designation, commonly referred to as the Magnet journey. There are no published reports regarding the impact of this transformational process on staff nurses. METHODS: Focus groups were conducted at recently designated Magnet hospitals; data were transcribed, reviewed, coded, and themed. The 58 subjects represented various work areas, specialties, and practice sites. RESULTS: Key themes emerged consistent with components of the Magnet model: relationships with leaders, professional accountability, staff voice, Magnet continuum, professional relationships, professional development, and resources/supports. Overall, staff nurses emphasized the positive impact of the transformation that occurred during the journey and the resultant Magnet designation on stakeholders. CONCLUSIONS: Results from this study offer guidance for Magnet project directors, chief nursing officers, managers, advanced practice nurses, and staff nurses involved in or considering the Magnet journey. “Magnet slippage” emerged as a new concept.
Company builder: Innovatives Risikokapital als Motor des Beschäftigungswachstums

In den vergangenen ca. 15 Jahren haben sich neue Formen der Risikokapitalfinanzierung gebildet, die das Grunden von Unternehmen zu einem eigenen Geschaftsfeld gemacht haben. Die sogenannten 'Company Builder' bringen eigene Grundungsideen auf den Weg und unterstutzen die Startups langfristig. Die von Company Buildern geschaffenen Unternehmen weisen im Vergleich zu den Startups anderer Risikokapitalgeber in Deutschland die zweitmeisten Beschaftigten hinter den klassischen Venture Capital-Gesellschaften auf. Zugleich haben ihre Unternehmen die hochste Beschaftigtendynamik. Das Geschaftsmodell der Company Builder hat sich besonders erfolgreich in Deutschland etabliert. Dies scheint durch ihre Passfahigkeit zu einigen Elementen des deutschen Innovations-systems gefordert zu werden. Bislang sind die Company Builder sektoral vor allem in den Branchen der Informations- und Kommunikationstechnik sowie raumlich am Standort Berlin aktiv. Das Geschaftsmodell der Company Builder bietet auch fur andere Regionen Chancen bei dem Aufbau einer aktiven Risikokapital-Szene und konnte bei der Erschliesung weiterer Branchen, Technologien und Markte genutzt werden.
Validation of Exceptional Longevity

This is a selection of studies by various authors on the problems associated with validating claims of exceptional longevity. "The history of longevity is a history of myths. This volume shows that most reported instances of exceptional longevity are incorrect. This was the rule everywhere until the end of the 19th century and is still the case in the vast majority of countries. It is only when reliable birth registrations are available for a century or more and when reports of ages above 100 are systematically checked against these data that the quality of national statistics on exceptional longevity improves. Several chapters of this volume provide further evidence that genuine centenarians before 1800 were nonexistent or at least extremely rare. " (EXCERPT)
Understanding financial conflicts of interest.

The problem of conflicts of interest began to receive serious attention in the medical literature in the 1980s1,2. Studies have described a wide range of conflicts involving physicians, medical researchers, and medical institutions (the most comprehensive is by Rodwin3). Among the areas of concern are self-referral by physicians,4–6 physicians' risk sharing in health maintenance organizations (HMOs) and hospitals,7 gifts from drug companies to physicians,8,9 hospital purchasing and bonding practices,3 industry-sponsored research,10,11 and research on patients12. Yet the concept of conflict of interest itself has been inadequately analyzed, and consequently its elements, the purposes .
RAPSearch 2 : a fast and memory-efficient protein similarity search tool for next-generation sequencing data

Summary: With the wide application of next-generation sequencing (NGS) techniques, fast tools for protein similarity search that scale well to large query datasets and large databases are highly desirable. In a previous work, we developed RAPSearch, an algorithm that achieved a ∼20–90-fold speedup relative to BLAST while still achieving similar levels of sensitivity for short protein fragments derived from NGS data. RAPSearch, however, requires a substantial memory footprint to identify alignment seeds, due to its use of a suffix array data structure. Here we present RAPSearch2, a new memory-efficient implementation of the RAPSearch algorithm that uses a collision-free hash table to index a similarity search database. The utilization of an optimized data structure further speeds up the similarity search—another 2–3 times. We also implemented multi-threading in RAPSearch2, and the multi-thread modes achieve significant acceleration (e.g. 3.5X for 4-thread mode). RAPSearch2 requires up to 2G memory when running in single thread mode, or up to 3.5G memory when running in 4-thread mode. Availability and implementation: Implemented in C++, the source code is freely available for download at the RAPSearch2 website: http://omics.informatics. indiana.edu/mg/RAPSearch2/. Contact: yye@indiana.edu Supplementary information: Available at the RAPSearch2 website. Received on August 10, 2011; revised on September 29, 2011; accepted on October 23, 2011
The Generation of the Reversible Gate Network-Based the Variable System Numbers

Reversible calculating is an emerging area of research and reversible logic synthesis is its important aspect. This paper proposed the reversible logic gate network cascade method-based the variable system numbers, which can generate single reversible network or the batching continuous sequence numbers reversible network. Via the corresponding relationship between the variable system numbers and reversible network output vectors, we can locate quickly the corresponding sequence numbers of the reversible network output vectors and judge preciously whether the output vectors have been appeared meanwhile reducing the times of search and search space. Compared with examples of the benchmark, the number of control-bit and the number of the reversible logic gates have been improved to some degree.
A systematic review of the emerging deﬁnition of 'deprescribing' with network analysis: implications for future research and clinical practice.

AIMS The aim of this study was to identify what definitions have been published for the term 'deprescribing', and determine whether a unifying definition could be reached. A secondary aim was to uncover patterns between the published definitions which could explain any variation. METHODS Systematic literature searches were performed (earliest records to February 2014) in MEDLINE, Embase, CINAHL, Informit, Scopus and Google Scholar. The terms deprescrib* or de-prescrib* were employed as a keyword search in all fields. Conventional content analysis and word frequencies were used to identify characteristics of the definitions. Network analysis was conducted to visualize characteristic distribution across authors and articles. RESULTS Following removal of duplicates, 231 articles were retrieved, 37 of which included a definition. Eight characteristics of the definitions were identified: use of the term stop/withdraw/cease/discontinue (35 articles), aspect of prescribing included e.g. long term therapy/inappropriate medications (n = 18), use of the term 'process' or 'structured' (n = 13), withdrawal is planned/supervised/judicious (n = 11), involving multiple steps (n = 7), includes dose reduction/substitution (n = 7), desired goals/outcomes described (n = 5) and involves tapering (n = 4). Network analysis did not reveal patterns responsible for variations in previously used definitions. CONCLUSIONS These findings show that there is lack of consensus on the definition of deprescribing. This article proposes the following definition: 'Deprescribing is the process of withdrawal of an inappropriate medication, supervised by a health care professional with the goal of managing polypharmacy and improving outcomes'. This definition has not yet been externally validated and further work is required to develop an internationally accepted and appropriate definition.
Label-Free Monitoring of Diffusion in Microfluidics

Label-free, real-time detection of concentration gradients is demonstrated in a microfluidic H-filter, using an integrated photonic crystal slab sensor to monitor sample refractive index with spatial resolution. The recorded diffusion profiles reveal root-mean-square diffusion lengths for non-fluorescing and non-absorbing molecules, both small (glucose, 180 Da) and large (bovine serum albumin, 67 kDa).