Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization and Modeling of a Current Transformer Working Under Thermal Stress

This paper focuses on the thermal stress on magnetic materials under Curie temperature. The influence of the temperature on static and dynamic major B(H) loops is studied. Then, the Jiles-Atherton (JA) model and “flux tube” model are used, in order to reproduce the static and dynamic hysteresis loops for a NiFe (80/20) alloy. For each temperature, the six model parameters are optimized from measurements. Finally, these parameters are used in order to reproduce the behavior of a current transformer. The simulation results are compared with measurements and discussed.
Thrombus Detection in CT Brain Scans using a Convolutional Neural Network

Automatic detection and measurement of thrombi may expedite clinical workflow in the treatment planning stage. Nevertheless it is a challenging task on non-contrast computed tomography due to the subtlety of the pathological intensity changes, which are further confounded by the appearance of vascular calcification (common in ageing brains). In this paper we propose a 3D Convolutional Neural Network architecture to detect these subtle signs of stroke. The architecture is designed to exploit contralateral features and anatomical atlas information. We use 122 CT volumes equally split into training and testing to validate our method, achieving a ROC AUC of 0.996 and a Precision-Recall AUC of 0.563 in a voxel-level evaluation. The results are not yet at a level for routine clinical use, but they are encouraging.
MicroRNA‐10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC

MicroRNAs (miRNAs) are effective post‐transcriptional regulators of gene expression and are important in many biological processes. Although the oncogenic and tumor suppressive functions of several miRNAs have been characterized, the role of miRNAs in mediating tumor invasion and migration remains largely unexplored. Recently, miR‐10b was identified as an miRNA highly expressed in metastatic breast cancer, promoting cell migration and invasion. Here, we performed real‐time reverse transcriptase polymerase chain reaction (RT‐PCR) assays on 43 glioma samples (17 glioblastoma, 6 anaplastic astrocytoma, 10 low‐grade astrocytoma, 6 oligodendroglioma and 4 ependymoma) and 6 glioma cell lines. We found that miR‐10b expression was upregulated in all glioma samples compared to non‐neoplastic brain tissues. The expression levels of miR‐10b were associated with higher grade glioma. In addition, mRNA expressions of RhoC and urokinase‐type plasminogen activator receptor (uPAR), which were thought to be regulated by miR‐10b via HOXD10, were statistically significantly correlated with the expression of miR‐10b (p < 0.001, p = 0.001, respectively). Also, protein expression levels of RhoC and uPAR were associated with expression levels of miR‐10b (p = 0.009, p = 0.014, respectively). Finally, multifocal lesions on enhanced MRI of 7 malignant gliomas were associated with higher expression levels of miR‐10b (p = 0.02). Our data indicated that miR‐10b might play some role in the invasion of glioma cells. © 2009 UICC
In Vitro Prediction and in Vivo Verification of Enantioselective Human Tofisopam Metabolite Profiles

In vitro studies were conducted to elucidate the metabolic profiles of and the enzymes responsible for the metabolism of (R)- and (S)-tofisopam (1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine). Large differences were observed between the two enantiomers. The major metabolite in incubations of 500 ng/ml (≈1.3 μM) (R)-tofisopam in human liver microsomes corresponded to demethylation of the methoxy group at the 4-position of the phenyl ring (M3). Incubating (R)-tofisopam with recombinant cytochrome P450 (P450) or with human liver microsomes and isoform-selective P450 chemical inhibitors indicated that M3 was primarily catalyzed by CYP2C9. Similar incubations with S-tofisopam indicated that the primary metabolite was due to demethylation of the methoxy group at the 7-position of the benzodiazepine ring (M1), and this reaction was catalyzed primarily by CYP3A4. The primary metabolites of both enantiomers were further demethylated to form a common didemethylated metabolite (M5) where the methoxy groups at positions 4 and 7 are demethylated. Analysis of plasma and urine samples from human clinical trials confirmed the in vitro observations. Subjects orally treated with 200 mg b.i. d. (R)-tofisopam had a 2-h M1/M3 plasma ratio of 1:29 and a ratio of 1:123 in urine, whereas patients orally administered (S)-tofisopam at 150 mg/kg t.i. d. had opposite M1 to M3 ratios of 8:1 in plasma and 6:1 in urine.
A novel rapid and effective donor arm disinfection method

BACKGROUND: The aim of the study was to derive a donor arm disinfection technique that was rapid, but with a disinfection efficacy equivalent to a previous “best‐practice” technique. This method consisted of a two‐stage procedure with an initial application of 70% isopropyl alcohol and then 2% tincture of iodine (IATI). The total time for the IATI method was 2 minutes in duration. A rapid technique (1 min in duration) was needed to obviate potential problems due to increased donor waiting time, had the IATI method been implemented at blood donation sessions.
Nasopharyngeal carcinoma risk prediction via salivary detection of host and Epstein-Barr virus genetic variants

Genetic susceptibility and Epstein-Barr virus (EBV) infection are important etiological factors in nasopharyngeal carcinoma (NPC). In this study, in southern China, where NPC is endemic, a single nucleotide polymorphism (SNP) in the EBV-encoded RPMS1 gene (locus 155391: G > A [G155391A]) and seven host SNPs (rs1412829, rs28421666, rs2860580, rs2894207, rs31489, rs6774494, and rs9510787) were confirmed to be significantly associated with NPC risk in 50 NPC cases versus 54 hospital-based controls with throat washing specimens and 1925 NPC cases versus 1947 hospital-based controls with buffy coat samples, respectively. We established a strategy to detect the NPC-associated EBV and host SNPs using saliva samples in a single test that is convenient, noninvasive, and cost-effective and displays good compliance. The potential utility of this strategy was tested by applying a risk prediction model integrating these EBV and host genetic variants to a population-based case-control study comprising 1026 incident NPC cases and 1148 controls. Receiver operating characteristic (ROC) curve analysis revealed an area under the curve of the NPC risk prediction model of 0.74 (95% CI: 0.71−0.76). Net reclassification improvement (NRI) analysis showed that inclusion of the EBV SNP significantly improved the discrimination ability of the model (NRI = 0.30, P < 0.001), suggesting the promising value of EBV characteristics for identifying high-risk NPC individuals in endemic areas. Taken together, we developed a promising NPC risk prediction model via noninvasive saliva sampling. This approach might serve as a convenient and effective method for screening the population with high-risk of NPC.
A filter based feature set selection approach for big data classification of patient records

The flourishing fame and development of big data in recent years made researchers to have a detailed study. Of the all entire emerging big data research topics, classification of data from big data is identified as a great challenge to address as of our analysis. The Classification is the process of categorizing data for its most effective and efficient use. While analyzing large scale patient records, hierarchical learning approach which is tree structured that train max-margin classifier will give better classification results and also it is computationally efficient. The quality of features has an effect on the performance of hierarchical learning approach for classification of patient records. So we have to extract discriminative features for training hierarchical classifier. In this paper Highly Correlated Feature Set Selection (HCFS) algorithm is proposed to combine with the hierarchical leaning approach to improve its performance. This algorithm identifies the good feature subsets which will improve the classification accuracy.
Protective Effect of α-Tocotrienol against Free Radical-Induced Impairment of Erythrocyte Deformability

α-Tocotrienol (α-T3) has been suggested to protect cellular membranes against free radical damage. This study was done to estimate the effect of α-T3 on free radical-induced impairment of erythrocyte deformability by comparing it to α-tocopherol (α-T). An erythrocyte suspension containing 2,2′-azobis (2-amidinopropane) dihydrochloride (AAPH) was forced to flow through microchannels with an equivalent diameter of 7 μm for measuring erythrocyte deformability. A higher concentration of AAPH caused a marked decrease in erythrocyte deformability with concomitant increase of membranous lipid peroxidation. Treatment of erythrocytes with α-T or α-T3 suppressed the impairment of erythrocyte deformability as well as membranous lipid peroxidation and they also increased erythrocyte deformability even in the absence of AAPH. In these cases, the protecting effect of α-T3 was significantly higher than that of α-T. We emphasize that higher incorporating activity of α-T3 into erythrocyte membranes seems to be the most important reason for higher protection against erythrocyte oxidation and impairment its deformability.
Convergent recombination shapes the clonotypic landscape of the naïve T-cell repertoire

Adaptive T-cell immunity relies on the recruitment of antigen-specific clonotypes, each defined by the expression of a distinct T-cell receptor (TCR), from an array of naïve T-cell precursors. Despite the enormous clonotypic diversity that resides within the naïve T-cell pool, interindividual sharing of TCR sequences has been observed within mobilized T-cell responses specific for certain peptide–major histocompatibility complex (pMHC) antigens. The mechanisms that underlie this phenomenon have not been fully elucidated, however. A mechanism of convergent recombination has been proposed to account for the occurrence of shared, or “public,” TCRs in specific memory T-cell populations. According to this model, TCR sharing between individuals is directly related to TCR production frequency; this, in turn, is determined on a probabilistic basis by the relative generation efficiency of particular nucleotide and amino acid sequences during the recombination process. Here, we tested the key predictions of convergent recombination in a comprehensive evaluation of the naïve CD8+ TCRβ repertoire in mice. Within defined segments of the naïve CD8+ T-cell repertoire, TCRβ sequences with convergent features were (i) present at higher copy numbers within individual mice and (ii) shared between individual mice. Thus, the naïve CD8+ T-cell repertoire is not flat, but comprises a hierarchy of recurrence rates for individual clonotypes that is determined by relative production frequencies. These findings provide a framework for understanding the early mobilization of public CD8+ T-cell clonotypes, which can exert profound biological effects during acute infectious processes.
Interaction of guanine nucleotides with the kainate binding protein from chick cerebellum

&NA; The interaction of guanine nucleotides with the chick cerebellar kainate binding protein (chKBP) was studied using binding assays, immunoblotting, and in vitro phosphorylation experiments. Guanosine 5′‐triphosphate (GTP) was found to reduce [3H]kainic acid (KA) binding in a concentration‐dependent manner. Similarly, an inhibition of [3H]GTP binding by KA was observed. No G protein co‐purified with chKBP. chKBP phosphorylation by the cAMP‐dependent protein kinase (PKA) was prevented both by KA and by GTP. Neither KA nor GTP blocked each other's effect in chKBP phosphorylation. The present findings suggest that chKBP harbours two agonistic binding sites, one in the micromolar range, detected by binding techniques and one in the millimolar range detected by phosphorylation assays. Guanine nucleotides interact with both sites.
Media Use and Sleep.

Media use can include broadcast media such as television and movies, as well as interactive media such as social media and online games. Further, media use via portable devices such as smartphones and tablets has made media use available 24 hours a day and at most any location. One area of health concern with children’s media use is its effect on sleep. Concerns about media use and sleep include that using media at or near bedtime can lead to fewer hours of sleep and poorer quality of sleep. Concerns have also been raised about media use leading to daytime sleepiness, which could affect children’s school performance and other physical health issues. Sleeping the recommended hours on a regular basis is necessary and associated with better health outcomes including improved attention, behavior, learning, memory, emotional regulation, quality of life, and mental and physical health. Children 6 to 12 years of age should get 9 to 12 hours of sleep and teens 13 to 18 years of age should get 8 to 10 hours each night. More information about number of hours of recommended sleep for children and adolescents is available from the American Academy of Sleep Medicine (http://www.aasmnet.org /Resources/pdf/Pediatricsleepdurationconsensus.pdf). This issue of JAMA Pediatrics includes a study of the relationship between media use and sleep outcomes. This meta-analysis study allows an independent group of investigators to review and summarize findings from previous studies, leading to an evidencebased summary of the state of the science on a given topic. This meta-analysis included 20 previous studies from around the globe; in total, the studies included 125 198 children. The analysis found the following evidence regarding the relationship between media use and sleep:
Invited commentary: Will heart attacks be "gone with the century"?

A frequently quoted editorial by Brown and Goldstein (1) speaks to the importance of myocardial infarction trends as indicators of progress in the battle against heart disease. Indeed, the increase in life expectancy in developed societies compounds the burden of coronary disease in the later stages of life, which has a major impact on the health of the US population. Population-based trends in disease rates are the final measures of the effect of interventions aimed at reducing the burden of disease. This underscores the importance of careful monitoring of coronary heart disease trends for public health, policy-making, and health economics. Myocardial infarctions are an essential component of the burden of coronary disease. While they do not represent all manifestations of the disease, the existence of established criteria amenable to standardization have made myocardial infarction one of the indicators of choice for tracking coronary disease over time.
Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet–Induced Obese Rats

LY2584702 is an inhibitor of p70 S6 kinase-1 previously developed for the treatment of cancer. In two phase 1 trials in oncology patients, significant reductions of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglyceride were observed. In the current study, we sought to understand the potential mechanism of action of this compound in regulating lipid metabolism. In Long Evans diet–induced obese (DIO) rats, oral administration of LY2584702 for 3–4 weeks led to robust reduction of LDL-C up to 60%. An unexpected finding of liver triglyceride (TG) increase implicated a metabolite of LY2584702, 4-aminopyrazolo[3,4-day]pyrimidine (4-APP), in modulation of lipid metabolism in these rats. We showed that low-dose 4-APP, when administered orally for 3–4 weeks to Long Evans DIO rats, produced lipoprotein profile changes that were strikingly similar to LY2584702. Kinetic studies suggested that both LY2584702 and 4-APP had no effect on chylomicron-TG secretion and only exerted a modest effect on hepatic very low-density lipoprotein (VLDL)-TG secretion. In human hepatoma HepG2 cells, 4-APP, but not LY2584702, increased LDL uptake. We hypothesize that generation of the 4-APP metabolite may contribute to the efficacy of LY2584702 in lowering LDL-C in rats and potentially in humans as well. This mechanism of LDL-C lowering may include inhibition of VLDL production and increase in LDL clearance.
Four valued logic for relational database systems

This paper proposes a specific four-valued logic (4VL) as a means of handling missing data in Relational Data Base Management systems. The proposed 4VL is a minor variant of the standard 4VL in which the “least true” condition is interpreted as “inapplicable” rather than “false”. The use of this 4VL is defended on the grounds that by defining several additional unary operators, the 4VL can be rendered intuitively manageable. The proposed unary operators contribute to the conceptual utility of the 4VL by providing an explicit way for users to relate familiar results of two-valued logic to analogous results in 4VL.
A solid reusable endorectal receiver coil for magnetic resonance imaging of the prostate: Design, use, and comparison with an inflatable endorectal coil

We have designed a solid endorectal receiver coil for MRI of the prostate. The coil provided an improved signal‐to‐noise ratio up to 5 cm from its surface when compared with a standard pelvic phased array. This preliminary report describes 16 patients who were imaged using this coil, seven of whom had been examined previously with a balloon‐design endorectal coil. Patient tolerance of these coils was compared. The solid coil was easy to insert and quick to set up because it did not require external tuning and matching. It avoided uncomfortable rectal distension experienced with the balloon coil as well as susceptibility artifacts from air in the balloon. In addition, it could be sterilized and reused.
Lipid rafts identified as locations of ectodomain shedding mediated by Meltrin β/ADAM19

Meltrin β (Mel β, also called ADAM19) is a member of the ADAM (adisintegrin and metalloprotease) family, which are membrane‐anchored glycoproteins that play crucial roles in various biological processes. Many intercellular signaling molecules are membrane‐anchored proteins, which are proteolytically processed after becoming membrane‐bound, to liberate their extracellular domains (ectodomain shedding). Genetic and biochemical studies have shown that some ADAMs participate in these events. We found previously that Mel β can cleave the extracellular region of the membrane‐anchored β‐exon‐containing Neuregulin‐1 (NRG β1) protein, which is one of the main ligands for the neural ErbB receptor. Mel β‐deficient mice showed developmental defects in the nervous system. These observations raise the possibility that the NRG ectodomain shedding mediated by Mel β is closely related to the neural development. Here we show that Mel β‐mediated ectodomain shedding of NRG β1 takes place in the lipid rafts of neurons. The lipid rafts localization of Mel β requires its membrane‐anchoring region, and NRG β1 ectodomain shedding is not enhanced if Mel β cannot reach the lipid rafts. These results indicate that localization of Mel β in lipid rafts is critical for its ectodomain shedding.
Laboratory Diagnosis of Common Viral Infections of the Central Nervous System by Using a Single Multiplex PCR Screening Assay

ABSTRACT A multiplex PCR assay that detects the four commonest causes of viral meningitis and encephalitis in the United Kingdom (herpes simplex virus [HSV] type 1 [HSV-1], HSV type 2 [HSV-2], varicella-zoster virus [VZV], and enteroviruses) was developed, and its sensitivity was compared with those of similar assays described previously for this application. Compared to the previous assays, this single multiplex PCR assay had higher molecular sensitivities for the detection for each of the viruses and improved utility for routine use in a diagnostic laboratory. The assay was used to test a series of 1,683 consecutive cerebrospinal fluid (CSF) samples between June 1997 and March 1998 inclusively. Viral nucleic acid was detected in 138 (8.2%) of the CSF samples, including enteroviruses in 51 samples, HSV-2 in 33 samples, VZV in 28 samples, and HSV-1 in 25 samples. Compared to the accepted relative incidence of viral etiologies, aseptic meningitis due to HSV-2 infection was high, and in adult female patients with symptoms of aseptic meningitis, HSV-2 was the virus most commonly detected in the CSF.
The influence of post-growth thermal treatments on the critical current density of TSMG YBCO bulk superconductors

Oxygenation and thermochemical post-growth treatments of top seeded melt-growth (TSMG) YBCO bulk superconductors can significantly influence critical current density. It is shown that, depending on oxygenation conditions and the size of 211 particles, different reductions of intrinsic critical current density values can be obtained due to the reduction in the sample cross-section caused by the presence of a/b-microcracks induced by 211 particles, and a/b- and a/c-cracks induced by oxygenation. The possibility of eliminating oxygenation cracks by high pressure oxygenation and consequently significantly increasing the macroscopic critical current density is demonstrated. An effective dopant concentration for chemical pinning is proposed and possible clustering of substitutions in the Y123 lattice by thermochemical treatments is shown.
Early Carotid Artery Stenting and Angioplasty in Patients with Acute Ischemic Stroke

OBJECTIVE:To determine the safety of early percutaneous endovascular carotid angioplasty and stenting (CAS) after an ischemic stroke. METHODS:The neurointerventional database was reviewed for patients who underwent CAS after an acute ischemic stroke in two university hospitals. Clinical and radiological data were reviewed. Outcomes were worsening stroke, new stroke, or stroke-related death up to 30 days after the procedure. Procedure-related complications were also documented. RESULTS:A total of 38 patients with 39 procedures were identified. The mean age was 67 ± 15 years; 31 of 38 patients were Caucasian and 24 were female. Hypertension was found in 21 patients, peripheral vascular disease in 12, diabetes in 13, and coronary artery disease in 18. The median initial National Institutes of Health Stroke Scale score was 8. The carotid artery showed severe to high-grade stenosis in 28 patients, dissection was present in 6, and the rest had an acute occlusion treated with thrombolysis followed by CAS. The mean time from stroke onset to CAS was 55 ± 34 hours. The mean degree of stenosis at baseline was 86 ± 11%. In 37 procedures, complete recanalization was achieved, defined as less than 10% residual narrowing; in 2 procedures, the residual stenosis was mild (10–20%). Neurological deterioration occurred after three procedures (7.7%), with minor nondisabling stroke in two and death from intracranial hemorrhage in one. CONCLUSION:If deemed necessary and in certain circumstances, early CAS seems to be safe after acute ischemic stroke if infarction volume is small and neurological deficit is mild.