Miracle-dz/UniFAR-FTUs huggingface dataset:
DETERMINATION OF CORRELATIVE RELATIONS BETWEEN SOCIAL CAPITAL, TRUST AND MOTIVATION IN THE INTERNATIONAL COMPANY

Conception of the Social Capital is used by many scientists. It established its wide place in economic, social, politological and other sciences. Along with natural and human capital the social capital essentially influences the growth of efficiency of the transnational companies and promotes their development. The social capital is not the property of individual persons, it is established in the social networks and differs from other forms of capital by the fact that it is reflected not in objects and sujects, but in the human relations that form a social network. In general, conception of the social capital is inhomogenous and contracdictory. Despite this, it still establishes a worthy place in economic and social science. Conception of the social capital is based on the phenomenon of confidence. On the basis of ethical and philosophical analysis of the category of confidence it can be convincingly said that without this category development of the society is impossible only by the economic mechanisms. The present study, on the basis of theoretical-methodological, regressive analysis of categories of the social capital and confidence, establishes those empiric relations, which exist between these two categories. Use of the auggested methodology in improvement of the management activity of the modern corporations is important, because it promotes their development and growth.
NT-Pro-BNP levels and their response to exercise in patients with slow coronary flow.

BACKGROUND Natriuretic peptides are released by the heart in response to wall stress. OBJECTIVE The NT-Pro-BNP concentrations in slow coronary flow (SCF) patients were assessed before and after the exercise test and compared with the values of healthy controls. METHODS The study population was 34 patients with SCF [22 males (64.7%), aged 51.0 ± 6.2 years], and 34 normal subjects with normal coronary arteries [21 males (61.8%), aged 53.2 ± 6.6 years]. Coronary flow rates of all patients and control subjects were documented as Thrombolysis in Myocardial Infarction (TIMI) frame count. Blood samples were drawn at rest and after the exercise testing. RESULTS The baseline NT-Pro-BNP concentrations of the SCF patients were higher than those of the control subjects (NT-Pro-BNP: 49.7 ± 14.2 pg/mL vs. 25.3 ± 4.6 pg/mL p<0.0001, respectively), and this difference increased after exercise test between the groups (NT-Pro-BNP: 69.5 ± 18.6 pg/mL vs. 30.9 ± 6.4 pg/mL p<0.0001). In SCF group after exercise, NT-Pro-BNP concentration in 15 patients with angina was higher than those without angina (76.8 ± 17.8 pg/mL vs. 63.8 ± 17.5 pg/mL p=0.041). NT-Pro-BNP concentration in 11 patients with ST depression was also higher than those without ST depression (82.4 ± 17.3 pg/mL vs. 63.3 ± 16.1 pg/mL p=0.004). Median post-exercise increases in NT-Pro-BNP (Δ NT-Pro-BNP) were higher in the SCF group than in the control group (Δ NT-Pro-BNP: 19.8 ± 7.7 pg/mL vs. 5.7 ± 4.5 pg/mL p<0.0001). CONCLUSION The results of this study suggest that there may be an important pathophysiologic link between the severity of SCF (microvascular or epicardial coronary artery dysfunction) and the level of circulating NT-Pro-BNP in SCF patients.
Cervical large cell neuroendocrine carcinoma with cytologic presentation: a case report.

BACKGROUND Large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive cervical neoplasm. Few cytologic or colposcopic findings of LCNEC have been reported. CASE A 37-year-old woman, gravida 6, para 4, presented with vaginal bleeding for 3 months. The cervical smears showed cells dispersed as single cells or arranged as loosely cohesive sheets or glandlike aggregate and the nuclear size was almost 3-5 times larger than that of small lymphocytes. The cytologic, pathologic and immunohistochemical examinations suggested LCNEC. The patient underwent a radical hysterectomy and then received radiation and systemic chemotherapy. CONCLUSION Cytologic and colposcopic findings for LCNEC of the uterine cervix are reported. Patients with LCNEC have poor prognoses. Early diagnosis of the tumor is important.
Health in the 5th 5-years Development Plan of Iran: Main Challenges, General Policies and Strategies

Access to the right to the highest attainable level of health is a constitutional right that obliges governments and other players to take step to increase all individuals’ chances of obtaining good health. At the least, health and education are two crucial requirements for this as well. Iran’s vision 2025 is going to lead the country to a developed state with the highest rank of economic, scientific and technological status in the region. Enjoying health, welfare, food security, social security, equal opportunities, etc, are also considered as part of characteristics of Iranian society in 2025. Although health system of Iran has many achievements in providing health services specially for the poor following the Islamic Revolution of 1979, but the evidences gathered to develop the 5th 5-years economical, social and cultural plan (5th5YDP:2011–2015), listed a variety of main challenges in stewardship, financing, resources generation and service provision functions of the existing health system. Thus, to overcome the main challenges, about 11% of general policies of 5th5YDP are directly address health related issues with emphasizing on healthy human and comprehensive health approach with considering: Integration of policy making, planning, evaluation, supervision and public financing; Developing both quantity and quality of health insurance system and reducing out-of-pocket expenditures for health services to 30% by the end of the 5th plan. The strategies of 5th5YDP adopted by the parliament as an Act will change the health system fundamentally through tuning the main drivers; so, its implementation needs brave leaders, capable managers, motivated technical staff and social mobilization.
Mental Health Care of Older People: Can the District Mental Health Program of India Make a Difference?

Background: District mental health program (DMHP) is the flagship program of Government of India to deliver mental health-care throughout the country. Being an out-reach program, it is likely that elderly people with mental health programs are accessing it more frequently. If this is the case, there is potential for including additional components in this program so that something more than the generic service is offered to them. Aim: This study aims to find out whether the elderly are accessing the DMHP services frequently. Materials and Methods: We compared the proportion of elderly people attending two mental health-care facilities: - A Government Medical College Out-patient Department and the clinics run by the DMHP of the same department. Results: A significantly higher number of elderly people are attending the clinics of the DMHP compared to the outpatient service of a teaching hospital. Conclusion and Implication: It is concluded that DMHP can be further strengthened by adding additional components like service for the elderly. This is important in view of the increasing number of older people who may need these services in future.
Live-feeling communication: Multi-algorithm approach to the estimation of human intentions

Live-feeling communication is a seamless process of intelligent system estimating user intention solely on passive user-to-robot communication of user emotions and body movements. In this paper we study the live-feeling communication in an entertainment framework; a real-time streaming event (football) is split into set of important and relevant scenes, and for each scene the user intention is estimated. For each scene the amount of desired details and the desired content is estimated. In order to obtain the best possible estimation result we predict the user intention for each scene using a set of different predictors by using a parameter search approach. We show that using the collected data certain situations can be estimated with accuracy of up to 95% while others are still beyond the reach of the used prediction algorithms.
Periodontal disease awareness among pregnant women in the central and eastern regions of Saudi Arabia.

AIM The purpose of this study was to assess the knowledge and awareness regarding periodontal disease and its effects on pregnancy among pregnant women in the central and eastern regions of Saudi Arabia. METHODS In this cross-sectional survey, self-administered, structured questionnaires were distributed to 300 pregnant women who were chosen randomly from attendees of maternity health care centers in the central and eastern regions of Saudi Arabia. The questions were developed from literature reviews of articles. The questionnaire addressed personal and sociodemographic variables, periodontal health awareness, and knowledge of pregnant women. The questionnaire was translated into Arabic and was pretested during the pilot study on a random sample of 50 pregnant women. Data were analyzed by χ(2) -tests, with the level of significance set at P < 0.05. RESULTS An overall response rate of 81% was obtained. Approximately 53% had a higher level of education, but only 21% knew how to define dental plaque and 30% knew its harmful effects. Almost 73% stated that gum disease could be prevented through toothbrushing and flossing. Approximately 97% of the respondents knew the negative effect of smoking, while only 12% knew there was a possible relationship between periodontal disease and adverse pregnancy outcomes. CONCLUSION The results of this cross-sectional study found that there is limited knowledge and awareness about periodontal disease and its possible effects on pregnancy among pregnant women attending maternal health care centers in the central and eastern regions of Saudi Arabia.
Cloning and Characterization of a Mammalian Prenyl Protein-specific Protease*

Proteins containing C-terminal “CAAX” sequence motifs undergo three sequential post-translational processing steps: modification of the cysteine with either a 15-carbon farnesyl or 20-carbon geranylgeranyl isoprenyl lipid, proteolysis of the C-terminal -AAX tripeptide, and methylation of the carboxyl group of the now C-terminal prenylcysteine. A putative prenyl protein protease in yeast, designated Rce1p, was recently identified. In this study, a portion of a putative human homologue of RCE1 (hRCE1) was identified in a human expressed sequence tag data base, and the corresponding cDNA was cloned. Expression of hRCE1 was detected in all tissues examined. Both yeast and human RCE1 proteins were produced in Sf9 insect cells by infection with a recombinant baculovirus; membrane preparations derived from the infected Sf9 cells exhibited a high level of prenyl protease activity. Recombinant hRCE1 so produced recognized both farnesylated and geranylgeranylated proteins as substrates, including farnesyl-Ki-Ras, farnesyl-N-Ras, farnesyl-Ha-Ras, and the farnesylated heterotrimeric G protein Gγ1 subunit, as well as geranylgeranyl-Ki-Ras and geranylgeranyl-Rap1b. The protease activity of hRCE1 activity was specific for prenylated proteins, because unprenylated peptides did not compete for enzyme activity. hRCE1 activity was also exquisitely sensitive to a prenyl peptide analogue that had been previously described as a potent inhibitor of the prenyl protease activity in mammalian tissues. These data indicate that both the yeast and the human RCE1 gene products are bona fide prenyl protein proteases and suggest that they play a major role in the processing of CAAX-type prenylated proteins.
Hyperpolarized [U‐2H, U‐13C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells

A resonance at ∼181 ppm in the 13C spectra of tumors injected with hyperpolarized [U‐2H, U‐13C]glucose was assigned to 6‐phosphogluconate (6PG), as in previous studies in yeast, whereas in breast cancer cells in vitro this resonance was assigned to 3‐phosphoglycerate (3PG). These peak assignments were investigated here using measurements of 6PG and 3PG 13C‐labeling using liquid chromatography tandem mass spectrometry (LC‐MS/MS)
Discordance of international adiposity classifications in Australian boys and girls – The LOOK study

Background: Various charts based on body mass index (BMI) and per cent body fat (%BF) are used to classify childhood body composition but outcomes may vary. Aim: The study investigated variation in incidences of childhood obesity as depicted by four classification charts. Subjects and methods: BMI and DXA-derived %BF were assessed in 741 children. Incidences of overweight and obesity were compared between two BMI charts and two bioelectrical impedance (BIA)-based %BF charts. Results: The International Obesity Task Force (IOTF)-adopted BMI chart designated 21%, 6% (boys), and 26%, 9% (girls) as overweight and obese, respectively. Corresponding figures using the USA CDC BMI chart were 27%, 11% (boys) and 27%, 12% (girls). Using a USA-derived %BF chart incidences were 17%, 2% (boys) and 21%, 8% (girls) and using a UK-derived %BF chart 51%, 24% (boys) and 53%, 36% (girls). Sensitivity of BMI varied according to the %BF reference chart. Conclusions: In contrast to the BMI-based charts, there were considerable variations in depicted incidences of obesity between the %BF-based charts. These discordances were considered to result from previously reported variation within and between BIA and DXA %BF assessments underlying the charts. The present study highlights the need for valid, reliable, unchanging BIA and DXA procedures.
Role of fibrillar Aβ25–35 in the inflammation induced rat model with respect to oxidative vulnerability

The major pathological ramification of Alzheimer's disease (AD) is accumulation of β-Amyloid (Aβ) peptides in the brain. An emerging therapeutic approach for AD is elimination of excessive Aβ peptides and preventing its re-accumulation. Immunization is the most effective strategy in removing preexisting cerebral Aβs and improving the cognitive capacity as shown in transgenic mice model of AD. However, active immunization is associated with adverse effect such as encephalitis with perivascular inflammation and hemorrhage. Details about the mechanistic aspects of propagation of these toxic effects are matter of intense enquiry as this knowledge is essential for the understanding of the AD pathophysiology. The present work aimed to study the oxidative vulnerability in the plasma, liver and brain of the inflammation-induced rats subjected to Aβ immunization. Induction of inflammation was performed by subcutaneous injection of 0.5 ml of 2% silver nitrate. Our present result shows that the proinflammatory cytokines such as IL1α and TNFα are increased significantly in the inflammation-induced, Aβ1–42, Aβ25–35 treated groups and inflammation with Aβ25–35 treated group when compared to control, complete Freund's adjuvant and Aβ35–25 treated groups. These increased proinflammatory cytokines concurrently releases significant amount of free radicals in the astrocytes of respected groups. The present result shows that nitric oxide (NO) level was significantly higher (P<0.001) in plasma, liver and brain of the rat subjected to inflammation, Aβ1–42, Aβ25–35 and inflammation with Aβ25–35 injected groups when compared to control. The increased level of lipid peroxides (LPO) (P<0.001) and decreased antioxidant status (P<0.05) were observed in the plasma, liver and brain of inflammation-induced group when compared to control. Our result shows that significant oxidative vulnerability was observed in the inflammation with Aβ treated rats when compared to other groups. Based on our results, we suggest that immunization of AD patients with Aβ should be done with caution as the increase in Aβ could trigger the brain inflammation in uncontrollable level.
Do loyalty programs really matter for hotel operational and financial performance

This study aims to use a sample of 2,120 individual hotel properties between 2011 and 2013 to evaluate the impact of loyalty programs on hotel operational and financial performance. ,This study provides empirical support for the impact of loyalty program based on both cross-sectional and panel data analyses and uses the instrumental variable technique to avoid potential heteroscedasticity, autocorrelation and simultaneity issues. ,Findings of this study show that loyalty program expenses have a significant and positive impact on all three operational performance indicators of RevPAR, ADR and Occupancy and the financial performance indicator of gross operating profit. ,This study suggests that the benefits of loyalty programs should be understood against the backdrop of a reasonable set of controlled variables such as e-commerce, franchise, advertising, other marketing expenses, hotel size and hotel chain scales. ,Given the conflicting viewpoints about the positive and negative impacts of loyalty programs, and that the literature is scant on empirical validation of the impact of loyalty programs on the overall operational and financial performance of hotel properties, this study is an early attempt to empirically test the impact of loyalty programs on a number of hotel operational and financial performance indicators by using an extensive list of individual hotel properties between 2011 and 2013.
Trick or treat? The effect of IMF programmes on mobilising FDI in CESEE countries

This paper investigates the effect of IMF programmes on foreign direct investment in the countries of Central, Eastern and Southeastern Europe. We use the original dataset for 17 countries in the region for the period from 1990 to 2013. In order to address selection bias stemming from the fact that countries are not randomly assigned to participation in IMF arrangements in a given year, and controlling also for the unobservable factors influencing both IMF participation and foreign investment, we employ the treatment effect model. The robustness of our findings was additionally assessed by the fixed effects instrumental variable panel and Arellano Bond dynamic panel estimation. Irrespective of the method used and model specification, we find that IMF arrangements negatively affect foreign direct investment in the CESEE region.
Orlistat in clozapine- or olanzapine-treated patients with overweight or obesity: a 16-week open-label extension phase and both phases of a randomized controlled trial.

OBJECTIVE To explore long-term effects of orlistat in adult clozapine- or olanzapine-treated patients with DSM-IV-diagnosed schizophrenia and overweight or obesity who tolerate orlistat. METHOD Orlistat or placebo was added to clozapine or olanzapine in stable doses in a 16-week randomized controlled trial. Open-label orlistat was added to the antipsychotics during a 16-week extension phase for those completing the double-blind phase. No low-calorie diet or participation in behavioral programs was required. Body weight (primary outcome) and some metabolic parameters were measured prospectively. Analyses were performed for those completing both phases (ie, population differing from that reported earlier). The study was conducted from 2004 through 2005. RESULTS During the open-label phase, the 44 patients experienced mean ± SD body weight loss of -1.29 ± 3.04 kg, P = . 007. During both phases, men (but not women) showed a weight loss of -2.39 ± 5.45 kg, P = . 023. Some subgroups showed desirable changes in several metabolic parameters. Prolonged (32 weeks) orlistat treatment yielded no additional benefits as compared to short (16 weeks) treatment. CONCLUSIONS In clozapine- or olanzapine-treated overweight or obese patients able to take orlistat on a long-term basis, the drug, with no concomitant hypocaloric diet or behavioral interventions, caused moderate weight loss only in men. However, some metabolic benefits may be achieved independently of weight changes. In patients who do not respond to orlistat within the first 16 weeks, continuation treatment may provide no additional benefits. TRIAL REGISTRATION controlled-trials.com Identifier: ISRCTN65731856.
The Cross-Sectional Variation of Skew Risk Premia

This paper estimates the variance risk premium (VRP) and the skew risk premium (SRP) for the individual stocks and indexes in the US financial markets, and then further analyzes the determinants of the cross-sectional variations of (i) the VRP and SRP for 40 indexes and stocks, (ii) the average VRP and SRP for a representative set of portfolios sorted by the VRP and SRP betas, and (iii) the future variance and skew risk premia. We find that (i) most of the stocks and indexes have negative and significant variance and skew risk premia; (ii) the default premium (DEF) is the key risk factor in the cross-sectional variation of average SRP payoffs; and (iii) there is a negative and statistically significant relation between the future SRP and the lottery demand factor (MAX).
Some Aspects of Actual CBI and Inflation in the Countries of Southeast Europe

Although the countries of Southeast Europe are connected in many ways, there are a lot differences among them with reference to development of the market economy, and especially in the way of conducting of the monetary policy and achieving of the price stability. The subject of this article's research is the actual central bank independence and its impact on monetary stability in the specific environment of Southeast European countries. Therefore, we applied it TOR as a research method because shorter average duration of the mandate of a central bank governor can be an obstacle for conducting of the monetary policy in the long run, as in such a case central bank would be less interested in obtaining its primary goal â€“ keeping of monetary stability. The main hypothesis in this study is that there was a significant influence of the actual central bank independence to monetary stability, regardless of different implementations of the monetary policies of the central banks of the observed countries. We have used statistical methods to prove the hypotheses and then we gave an adequate explanation of the research results. The result of our research has shown that in the period 2000-2016, despite their differences, actual independence of the respective central banks was strengthening, while the inflation rate in the countries of the Southeast Europe was decreasing, but the connection between the two was weak.
Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium.

SIGNIFICANCE Oxidative stress is a common denominator of various risk factors contributing to endothelial dysfunction and vascular diseases. Accumulated evidence suggests that sirtuin 1 (SIRT1) expression and/or activity is impaired by supraphysiological levels of oxidative stress, which in turn disrupts endothelial homeostasis. RECENT ADVANCES Several microRNAs (miRNAs) are induced by oxidative stress and termed as oxidative stress-responsive miRNAs. They may play a role linking the imbalanced redox state with dysregulated SIRT1. CRITICAL ISSUES This review summarizes recent findings on oxidative stress-responsive miRNAs and their involvement in SIRT1 regulation. Because of the unique characteristics of miRNAs, research in this new area requires an integrative approach that combines bioinformatics and experimental validation. Thus, a research strategy is discussed to identify the SIRT1-regulating miRNAs under oxidative stress and their functional outcomes in relation to endothelial dysfunction. Additionally, the miRNAs implicated in vascular diseases such as atherosclerosis and abdominal aortic aneurysms are discussed along with the translational potential and challenges of using miRNAs and its analogs as therapeutic agents. FUTURE DIRECTIONS Although at its infancy, research on oxidative stress-responsive miRNAs and their regulation of SIRT1 may provide new insights in understanding vascular disorders. Moreover, systematic approaches integrating in silico, in vitro, and in vivo observations can be useful tools in revealing the pathways modulating endothelial biology.