Miracle-dz/UniFAR-FTUs huggingface dataset:
[An Acinetobacter baumanii outbreak at the Versailles Hospital Center].

A. baumannii is a multiresistant bacteria which is recognised as responsible for nosocomial infections and hospital outbreaks. The control of these outbreaks depends on the strain's typing and on the fight's policy against nosocomial infections. An outbreak of A. baumannii is occurred to patients who were hospitalized in Centre Hospitalier de Versailles. To investigate this outbreak, we have determined the biotype (Bouvet's method), the succeptibility pattern (disk diffusion and agar dilution results were analysed with the hierarchical classification and main component analysis) and the total DNA macrorestriction pattern (Pulse Field Gel Electrophoresis using SmaI restriction enzyme). A risk factors for A. baumannii acquisition were delineated in case-control study. During 2 years, 38 patients have been infected or colonized to A. baumannii. Thirty two patients were hospitalized in ICU. We studied 38 non repetitive clinical isolates and 9 strains of the patient's rooms. Four biotypes were defined by the Bouvet's typing method. Fourteen groups were obtained when succeptibility results were analysed with the hierarchical classification and 6 with the main composant analysis. The molecular typing permit us to define 4 epidemic and 6 sporadic strains. All the epidemic strains were isolated on ICU hospitalized patients. Our study has shown wide contamination in patient's rooms (Water tap, dry surfaces, patient's mattresses.). Environmental objects have been a major risk factor for A. baumannii acquisition. The control of this outbreak has been possible by application of hygienic measures (hands washing, isolment, meticulous cleaning of the ICU and environmental controls). No new case is occurred in the last year. Typing methods and case-control study are necessary to investigate cross-infections and take efficient measures against these outbreaks.
Ovine Adenovirus Vectors Overcome Preexisting Humoral Immunity against Human Adenoviruses In Vivo

ABSTRACT Recombinant human adenoviruses (hAd) have become widely used as tools to achieve efficient gene transfer. However, successful application of hAd-derived vectors in clinical trials is limited due to immunological and potential safety problems inherent in their human origin. In this study, we describe a recombinant ovine adenovirus (OAV) as an alternative vector for gene transfer in vivo. In contrast to an hAd vector, the OAV vector was not neutralized by human sera. An OAV vector which contained the cDNA of the human α1-antitrypsin (hAAT) gene linked to the Rous sarcoma virus promoter was generated and administered systemically to mice. The level and duration of hAAT gene expression was similar to that achieved with an hAd counterpart in both immunocompetent and immunodeficient mice. However, the tissue distribution of the OAV vector differed from that observed for hAd vectors in that the liver was not the dominant target. Significantly, we demonstrated efficient gene transfer with the OAV vector into mice immunized with hAd vectors and vice versa. We also confirm that the immune response to a transgene product can prevent its functional expression following sequential application of a vector. Our results suggest a possible solution to endemic humoral immunity against currently used hAd vectors and should therefore have an impact on the design of improved gene therapy protocols utilizing adenovirus vectors.
How can bees colour graphs

Marriage in honey bees optimisation (MBO) is a recent evolutionary metaheuristic inspired by the bees reproduction process. Contrary to most of swarm intelligence algorithms such as ant colony optimisation (ACO), MBO uses self-organisation to mix different heuristics. In this paper, we present an MBO approach for the graph colouring problem (GCP). We propose, as worker, in our algorithm (BeesCol) one of the following methods: local search, taboo search or a proposed-based ant colony system algorithm (IACSCol). The worker intervenes at two levels; it improves initial and crossed solutions. Moreover, in BeesCol, one or several queens are generated randomly or by a specific constructive method, namely, recursive largest first or DSATUR. Experimental results on some well studied Dimacs graphs are reported. A comparison between BeesCol and some best-known algorithms for the GCP (hybrid colouring algorithm HCA, ant system and ant colony system) shows that the use of taboo search as worker in BeesCol reached most of best known results.
Case Presentation of a 45 Years Old Woman with Hypoglycemia and Bleeding

A patient was admitted to the hospital because of epistaxis, ecchymoses and gum bleeding with INR of 5.5. This patient had a known case of diabetes mellitus type II, 5 years ago. The last dose of glibenclamide for managing signs and symptoms of diabetes mellitus was 20 mg/day. Her medical history also showed that last month she was diagnosed with atrial fibrillation with normal left ventricular ejection fraction (LVEF> 45%) and was placed on warfarin (5 mg) and propranolol (80 mg) daily, which resulted in resolution of atrial fibrilation, a pulse rate of 80 bps and INR of 3 (target INR=2-3). An objective causality assessment indicated the increased effect of warfarin and as a result bleeding could best be explained by drug-drug interaction because there are no other factors such as pathological evidences (e.g. thyroid disease, hepatic disorders) to prove it otherwise. This case is the third report of drug interaction between warfarin and glibenclamide, therefore, this is an interesting and educational case. In view of our experience in the present case, it should be stressed that close monitoring of coagulation capacity is necessary in co-administration of warfarin and other drugs which can affect pharmacokinetic and pharmacodynamic of warfarin.
Synthesis of basement membrane by gastrointestinal cancer cell lines

Gastrointestinal adenocarcinoma‐derived cell lines were studied in order to determine their pattern of expression of basement membrane components and their ability to form a basement membrane. In contrast to the well‐preserved expression of laminin β2,β3,γ1, and γ2 chain mRNAs, five of eight gastrointestinal cancer cells lacked α3 mRNA. Immunohistochemical and electron microscopic examination of four cell lines transplanted subcutaneously to SCID mice demonstrated the presence of both α3 and α5 chains and the formation of a basal lamina in two cases. The other two cell lines lacked both α3 and α5 chains and could not form a basal lamina, suggesting that this deficiency may be a factor which affects their ability to form a basement membrane. This abnormality might play some role in stromal invasion by tumour cells in gastrointestinal cancer. Copyright © 1999 John Wiley & Sons, Ltd.
Evaluation of a kinetic model for computer simulation of growth and fermentation by Scheffersomyces (Pichia) stipitis fed D‐xylose

Scheffersomyces (formerly Pichia) stipitis is a potential biocatalyst for converting lignocelluloses to ethanol because the yeast natively ferments xylose. An unstructured kinetic model based upon a system of linear differential equations has been formulated that describes growth and ethanol production as functions of ethanol, oxygen, and xylose concentrations for both growth and fermentation stages. The model was validated for various growth conditions including batch, cell recycle, batch with in situ ethanol removal and fed‐batch. The model provides a summary of basic physiological yeast properties and is an important tool for simulating and optimizing various culture conditions and evaluating various bioreactor designs for ethanol production. Biotechnol. Bioeng. 2014;111: 1532–1540. © 2014 Wiley Periodicals, Inc.
Modelling the correlation between the thermal Sunyaev Zel'dovich effect and the cosmic infrared background

We show how the correlation between the thermal Sunyaev Zel’dovich effect (tSZ) from galaxy clusters and dust emission from cosmic infrared background (CIB) sources can be calculated in a halo model framework. Using recent tSZ and CIB models, we find that the size of the tSZ×CIB cross-correlation is approximately 20 per cent at 150 GHz. The contribution to the total angular power spectrum is around 2 �K 2 at l = 3000, however, this value is uncertain by a factor of two to three, primarily because of CIB source modelling uncertainties. We expect the large uncertainty in this component to degrade upper limits on the kinematic Sunyaev Zel’dovich effect (kSZ), due to similarity in the frequency dependence of the tSZ×CIB and kSZ across the frequency range probed by current Cosmic Microwave Background missions. We also find that the degree of tSZ×CIB correlation is higher for mm×sub-mm spectra than mm×mm, because more of the sub-mm CIB originates at lower redshifts (z . 2), where most tSZ clusters are found.
SYSTEM ANALYZE OF THE WINDKESSEL MODELS

This paper describes system analyze of the Windkessel models. The equations, space state and transfer functions of 2, 3 and 4 elements Windkessel models are described. The Simulink environment model schemas are presented as well. The Bode frequency and step response analyses are presented for all three models as well. Moreover the simulation of the special input signal which represents blood flow is described. The output signals are compared between each other and with existing published Winkessel models simulation. The results of comparison are discussed.
[Central pontine myelinolysis].

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Physically Realistic Motion Synthesis in Animation

Motion-synthesis problems arise in the creation of physically realistic animations involving autonomous characters. Trpically characters are required to perform goal tasks, subject to physical law and other constraints on their motion. Witkin and Kass (1988) dubbed this class of problems Spacetime Constraints (SC) and presented results for specific problems involving an articulated figure. Their approach was based on a procedure for the local optimization of an initial approximate trajectory supplied by the user. Unfortunately, SC problems are typically multimodal and discontinuous, and the number of decision alternatives available at each time step can be exponential in the number of degrees of freedom in the system. Thus, constructing even coarse trajectories for subsequent optimization can be difficult. We present an algorithm that constructs such trajectories de novo, without directive input from the user. Rather than use a time-series representation, which might be appropriate for local optimization, our algorithm uses a stimulus-response model. Locomotive skills appropriate for the given articulated figure are acquired through repeated testing of (simulated) reality. Our initial implementation, which chooses stimulus-response parameters using a parallel genetic algorithm, succeeds in finding good, novel solutions for a test suite of SC problems involving unbranched 2-D linkages.
Genetic analysis of Proteus mirabilis mutants defective in swarmer cell elongation

Swarmer cell differentiation is a complex process involving the activity of many gene products. In this report, we characterized the genetic locus of Tn5 insertion in each of 12 mutants defective in swarmer cell elongation. The mutations fell into four categories affecting either flagellar biosynthesis or energetics, lipopolysaccharide and cell wall biosynthesis, cellular division, or proteolysis of peptides.
Endoplasmic reticulum stress implicated in chronic traumatic encephalopathy.

OBJECTIVE Chronic traumatic encephalopathy is a progressive neurodegenerative disease characterized by neurofibrillary tau tangles following repetitive neurotrauma. The underlying mechanism linking traumatic brain injury to chronic traumatic encephalopathy has not been elucidated. The authors investigate the role of endoplasmic reticulum stress as a link between acute neurotrauma and chronic neurodegeneration. METHODS The authors used pharmacological, biochemical, and behavioral tools to assess the role of endoplasmic reticulum stress in linking acute repetitive traumatic brain injury to the development of chronic neurodegeneration. Data from the authors' clinically relevant and validated rodent blast model were compared with those obtained from postmortem human chronic traumatic encephalopathy specimens from a National Football League player and World Wrestling Entertainment wrestler. RESULTS The results demonstrated strong correlation of endoplasmic reticulum stress activation with subsequent tau hyperphosphorylation. Various endoplasmic reticulum stress markers were increased in human chronic traumatic encephalopathy specimens, and the endoplasmic reticulum stress response was associated with an increase in the tau kinase, glycogen synthase kinase-3β. Docosahexaenoic acid, an endoplasmic reticulum stress inhibitor, improved cognitive performance in the rat model 3 weeks after repetitive blast exposure. The data showed that docosahexaenoic acid administration substantially reduced tau hyperphosphorylation (t = 4.111, p < 0.05), improved cognition (t = 6.532, p < 0.001), and inhibited C/EBP homology protein activation (t = 5.631, p < 0.01). Additionally the data showed, for the first time, that endoplasmic reticulum stress is involved in the pathophysiology of chronic traumatic encephalopathy. CONCLUSIONS Docosahexaenoic acid therefore warrants further investigation as a potential therapeutic agent for the prevention of chronic traumatic encephalopathy.
Recent advances in surgical treatment of temporal lobe epilepsy

Introduction The safest, most effective, and most commonly performed surgical treatment for epilepsy is resection of the anterior temporal lobe for medically refractory complex partial seizures (1,2). Complex partial seizures (3), in turn, are the most common among all seizure types in patients with epilepsy (4). Furthermore, complex partial seizures are particularly resistant to standard antiepileptic drug treatment (3, and patients with these ictal events are the most likely of all epileptic patients to be referred to an epilepsy surgery facility. Consequently, there is now extensive worldwide experience with anterior temporal lobe resections for the treatment of medically refractory complex partial seizures, and advances in this area are immediately applicable to a large population of patients (6). This fortunate circumstance has thus made surgically oriented clinical research relatively more feasible for temporal lobe epilepsy than for other epilepsies, and the resultant progress is relatively more rewarding. A major factor directing current approaches to temporal lobe surgery has been the growing appreciation for a syndrome of mesial temporal lobe epilepsy (MTLE) characterized by seizures of mesial temporal limbic origin. Recognition of this syndrome, coupled with the continuing technological development of diagnostic tests that are particularly well suited for identifying mesial temporal epileptiform and nonepileptiform disturbances is greatly increasing our ability to offer surgical treatment to patients with medically refractory complex partial seizures, and to
Adsorption of Aqueous Oil on Sediments in the Bohai Tidal Flat

On the basis of the field investigation of oil contamination in the Tianjin tidal flat of Bohai Sea, three representative sediments are sampled in the vertical direction of the shoreline, and their major physico-chemical properties are analyzed. In addition, dynamic curves and isotherms of aqueous oil adsorption on sediments have been measured. At last, retard coefficients (R) of aqueous oil are calculated by means of columns experimental data. The studies show the equilibrium period of the adsorption is 20-24 hours, and all the adsorption isotherms are linear. The retard coefficient of sediments 1-2,1-3 and 3-1 are 1.17,1.64 and 1.75 respectively, which means aqueous oil in seawater can be adsorbed weakly by the sediment when seawater penetrates into the sediment of the tidal flats under wave and tidal action. As a result, the aqueous oil can easily migrate into the tidal flat and result oil pollution of tidal flat body.
Logistics Supply Chain Management Based on Heuristic Multi-Constrained Combinatorial Optimization Method

Fierce competition in global markets and the heightened expectations of consumers have forced business enterprises to invest in and focus attention on the relationships with their customers and suppliers and businesses increasingly realize that they no longer compete as solely autonomous entities. Logistics supply chain management has become more and more important for the major retailing corporations. Logistics supply chain optimized design and operating management mechanisms are modeled for the major retailing corporation logistics supply chain management through the multi-constrained combinatorial optimization expression in this paper. Novel scheme based on heuristic soft computing technique is proposed to efficiently solve the multi-constrained combinatorial optimization major retailing corporation logistics supply chain management problems.
Simulation of Light Interaction with Human Skin

Despite the notable progress in physically-based rendering, there is still a long way to go before one can automatically generate predictable images of organic materials such as human skin. In this tutorial, the main physical and biological aspects involved in the processes of propagation and absorption of light by skin tissues are examined. These processes affect not only skin’s appearance, but also its health. For this reason, they have also been the object of study in biomedical research. The models of light interaction with human skin developed by the biomedical community are mainly aimed at the simulation of skin spectral properties which are used to determine the concentration and distribution of various natural pigments. In computer graphics, the focus has been on the simulation of light scattering properties that affect skin appearance. Computer models used to simulate these spectral and scattering properties are described, and their strengths and limitations examined in detail in this tutorial. The emphasis of the discussions is on the predictive rendering of human skin, and open problems and new avenues of research in this area are also addressed.
A Wideband Omnidirectional Antenna Array With Low Gain Variation

An omnidirectional antenna array with wide band and low gain variation in the horizontal plane is proposed in this letter. The antenna unit of the array is composed of two vertically arrayed omnidirectional elements and the associated feeding network. 3-D dipoles with vertical arms and parasitic dipoles are introduced in the antenna unit to significantly enhance the bandwidth and decrease the gain variation. An array with three vertically installed units is fabricated. Each unit is 120 ° rotated compared to the neighboring one for a lower gain variation. The array exhibits a broad bandwidth of 56.4% (1.54-2.75 GHz) for VSWR ≤ 1.5, a gain around 7 dBi, and a low gain variation around 1.5 dB, which may find applications in base station for wireless communication or spectrum monitoring/jamming systems .
10-Year Follow-up of Split Anterior Tibial Tendon Transfer in Cerebral Palsied Patients with Spastic Equinovarus Deformity

Summary: Split anterior tibial tendon transfer was performed on 21 patients (27 feet) with cerebral palsy and spastic equinovarus deformity. All patients required orthoses preoperatively. All but two patients are now community ambulators with improved gait and without need for orthoses. There was one recurrence of deformity
Inverse association of serum 25-hydroxyvitamin D with markers of inflammation and suppression of osteoclastic activity in hemodialysis patients.

INTRODUCTION In hemodialysis patients, 25-hydroxyvitamin D conversion to active 1,25-dihydroxyvitamin D by the kidneys is very limited. The expression of both vitamin D receptor and 1alpha-hydroxylase in cells of the immune system and in both osteoblasts and osteoclasts makes it possible that 25-hydroxyvitamin D could play an important role in both inflammation and bone metabolism acting in a autocrine and/or paracrine way in these patients. MATERIALS AND METHODS Thirty-three hemodialysis patients not under vitamin D receptor agonist treatment were enrolled into the study. Serum levels of 25-hydroxyvitamin D, C-reactive protein (CRP), interleukin-6 (IL-6), receptor activator of nuclear factor-kappaB ligand (RANKL), and osteoprotegerin, as well as intact parathyroid hormone were assessed by immunoassays. RESULTS Regarding inflammation, 25-hydroxyvitamin D inversely correlated with both CRP and IL-6. Regarding bone metabolism, 25-hydroxyvitamin D was positively related to osteoprotegerin, but negatively to the RANKL. The latter could be the result of parathyroid hormone suppression by 25-hydroxyvitamin D, since 25-hydroxyvitamin D negatively correlated with parathyroid hormone, which in turn was positively related to RANKL. CONCLUSIONS Serum 25-hydroxyvitamin D is inversely correlated with markers of inflammation and may suppress osteoclastic activity in hemodialysis patients.
Parameter and State Estimation in Queues and Related Stochastic Models: A Bibliography

This is an annotated bibliography on estimation and inference results for queues and related stochastic models. The purpose of this document is to collect and categorise works in the field, allowing for researchers and practitioners to explore the various types of results that exist. This bibliography attempts to include all known works that satisfy both of these requirements: -Works that deal with queueing models. -Works that contain contributions related to the methodology of parameter estimation, state estimation, hypothesis testing, confidence interval and/or actual datasets of application areas. Our attempt is to make this bibliography exhaustive, yet there are possibly some papers that we have missed. As it is updated continuously, additions and comments are welcomed. The sections below categorise the works based on several categories. A single paper may appear in several categories simultaneously. The final section lists all works in chronological order along with short descriptions of the contributions. This bibliography is maintained at this http URL and may be cited as such. We welcome additions and corrections.