Miracle-dz/UniFAR-FTUs huggingface dataset:
SCHOOL LEADERSHIP CRITICAL TO MAXIMISING THE IMPACT OF ICT ON LEARNING

International research has consistently found that the organisation and leadership of a school are critical factors in the way in which educational technologies such as computers are used and their subsequent impact on learning opportunities in schools. This involves the Principal but also should involve a leadership team including a Curriculum leader (e.g. Director of Curriculum) who provides vision and support for teachers’ use of Information and Communications Technology (ICT), separate from but connected to technical ICT support. The formalisation of a leadership position to include such a leadership role is seen as a powerful strategy to link curriculum and ICT. Without the role there is little prospect of teachers and students realizing the potential for ICT to support them in teaching and learning. The effectiveness of such a role depends on its connection with leadership structure in the school, the status of the person or persons in the role, and a range of personal characteristics. The most successful have a combination of curriculum understanding and competence in the use of ICT. This paper explores this critical theme by drawing on a range of local research and national and international findings. It recommends leadership models, professional learning for school leaders and guidelines for policy and practice in schools. This paper refers to insights gained from research conducted at the Centre for Schooling and Learning Technologies (CSaLT), in particular an evaluation of a one-to-one notebook programme at John Willcock College (JWC) from 2004 to 2008 (C.P. Newhouse, 2008) and a five-year evaluation, involving over 50 government schools, of a project that provided some support for an ICT leadership position (there is a comprehensive analysis of some of the data in Tondeur, Cooper and Newhouse (In Press)). Both of these studies involved collecting both quantitative and qualitative data from staff and students over a number of years (methodology is outlined in Newhouse and Clarkson (2008)). It is not possible to discuss these evaluations in depth in this paper, therefore the reader is directed to the referred papers if these details are required. This paper will relate some of the findings of these studies to theoretical frameworks found in the literature, particularly that provided by Moyle (2006) in her report for Teaching Australia, Leadership and Learning with ICT. In general it was found that the position at JWC encapsulated more of the ‘better’ aspects of leadership that were found at some of the schools in the larger study and therefore JWC is referred to often throughout the paper. Where greater generalization is required the larger study provides the basis.
Stabilization of networked control systems with communication constraints and packet dropouts

This paper studies the stabilization problem for a class of networked control systems (NCSs) with communication constraints and random packet dropouts. The considered plant is equipped with multiple sensor nodes and actuator nodes. Only one of them can communicate with the controller at each transmission instant due to the communication constraints, and packet dropouts may occur at each transmission. A new transmission mechanism and state feedback controllers are considered, and the closed-loop NCS is modeled as a discrete-time switched system with a stochastic parameter. Sufficient conditions are derived for the closed-loop NCS to be exponentially mean square stable and a controller design procedure is also presented based on the obtained conditions. The effectiveness of the proposed method is shown by an illustrative example.
MicroRNAs: Clinical trials and potential applications

&NA; MicroRNAs are novel biomolecules with a crucial function in normal cellular physiology and in pathophysiologic conditions, including cancer. Since the first report on the link between microRNAs and cancer was published in 2002, research has revealed the potential clinical implications of microRNAs. Oncology nurses play an important role in educating patients and their families about possible applications of microRNAs in oncology. AT A GLANCEMicroRNAs are critical in regulating various biologic processes engaged in the promotion or inhibition of cancer growth.MicroRNAs may be biomarkers for various clinical applications, including diagnosis, prognosis, therapy response, treatment side effects, disease risk, disease progression, and metastasis.Numerous clinical trials involving microRNAs and cancer are in progress, with the aim of validating clinical application.
Investigation of nitrous oxide pollution arising from inhalational sedation for the extraction of teeth in child patients.

OBJECTIVES (i) TO test whether the exposure of dental staff to nitrous oxide during inhalational sedation with nitrous oxide/oxygen for extractions in children complies with specified occupational exposure standards, and (ii) to assess the atmospheric nitrous oxide concentration at one site close to the breathing zone of the operator/sedationist and to determine which patient- and sedation-related factors affect the level of nitrous oxide pollution. DESIGN Prospective study. SETTING Dental hospital sedation department, Newcastle Dental Hospital, UK. SAMPLE AND METHODS 20 inhalational sedation clinics each of 2 hours duration were evaluated, during which a total of 60 children aged 4-15 years had extractions carried out. Nitrous oxide was administered via a nose mask from a Quantiflex MDM inhalational sedation machine and active scavenging was used throughout. Exposure of dental staff was measured using personal dosimetry. Atmospheric nitrous oxide pollution at one fixed point, close to the breathing zone of the operator/sedationist, was assessed using infra-red gas analyser. RESULTS Mean exposure of the operator/sedationist to nitrous oxide during a single treatment clinic was 211 ppm, for the close support nurse 77 ppm and for the second nurse 67 ppm. Expressed as an 8 hour time-weighted average, the mean exposures were 39 ppm for the operator/sedationist, 17 ppm for the close support nurse and 15 ppm for the second nurse. The atmospheric nitrous oxide concentration varied during the clinics, with a maximum concentration of 538 ppm an a minimum that exceeded 100 ppm. There was a 71 minute delay following discharge of the last patient before atmospheric levels fell to zero. During sessions the degree of atmospheric pollution was inversely related to patient age (rc = -0.61, P < 0.05). There was a positive correlation between atmospheric pollution at the single point and the maximum percentage of nitrous oxide administered to each patient (rc = 0.57, P < 0.05). CONCLUSIONS In this study, staff exposure to nitrous oxide complied with the national occupational exposure standard but there was still considerable atmospheric nitrous oxide pollution during inhalational sedation for paediatric exodontia.
Anomaly Monitoring of Power Characteristic of Wind Turbine based on Multi-dimensional Clustering Method

Aiming at the limitation of traditional abnormal monitoring method of wind turbine. In this paper, we propose a multidimensional clustering method called WPMCLU. Firstly, traverse the FP-Tree storage structure to find subspace instead of APRIORI self-connection mode. Secondly, define K Gauss models and identify clusters in each subspace. At last, according to the parameter Eq specified by user to divide normal and abnormal cluster of each subspace, remove redundancy and recognize abnormal data. And the method we propose runs on the Spark platform in order to easily extend to large data set of wind power. In experiment, the method we propose in this paper has a high recognition rate compares with CLIQUE, K-Means and DBSCAN algorithms.
The effect of manual therapy on masseter muscle pain and spasm.

INTRODUCTION Orofacial pain and pain in the muscles of mastication are frequent symptoms of temporomandibular disorder. The masseter is the closet masticatory muscle to the surface and has the function of raising and retracting the mandible. This muscle has considerable strength and is one of the main muscles involved in the shredding of food It is therefore of utmost importance in the masticatory cycle and generally the most affected by pain and spasms. OBJECTIVES The aim of the present study was to analyze the effect of manual therapy with transversal and circular movements on pain and spasm in the masseter muscle, using electromyography and a visual analogue pain scale (VAPS). Eight women who experienced pain upon palpation of the masseter greater than 6 on the VAPS were selected for participation in the study, which employed electromyography and a VAPS for assessment, followed by manual oral physiotherapy and reevaluation. RESULTS The statistical analysis revealed a reduction in pain, but there was no significant difference in electromyographic activity (p < 0.05). CONCLUSION It was concluded that massage therapy was effective on pain symptoms, but was not capable of altering the electrical activity of the masseter muscle.
Very low density lipoprotein. Metabolism of phospholipids, cholesterol, and apolipoprotein C in the isolated perfused rat heart.

The fate of rat plasma very low density lipoprotein (VLDL) constituents was determined in the isolated perfused rat heart. VLDL was labeled with [(14)C]palmitate, (32)P-phospholipids, [(3)H] cholesterol, and (125)I-apolipoprotein C (apoC). Perfusions were performed with an albumin-containing buffer and without plasma. Radioactivity was followed in fractions of d < 1.019, d 1.019-1.04, d 1.04-1.21, and d > 1.21 g/ml, prepared by ultracentrifugation.VLDL triglycerides were progressively hydrolyzed to fatty acids (10-120-min perfusions). Concomitantly, phospholipids, cholesterol (predominantly unesterified), and apoC were removed from the VLDL to all other fractions. About 30-35% of the phosphatidylcholine was hydrolized to lysophosphatidylcholine and was recovered at d > 1.21 g/ml. The phosphatidylcholine-and triglyceride-hydrolyzing activities were confined to membrane supported enzyme(s). The other 60-65% of the phosphatidylcholine was removed unhydrolyzed and was found in fractions of d 1.019-1.04 (10-15%), d 1.04-1.21 (25-30%), and d > 1.21 g/ml (15-20%). [(32)P]Sphingomyelin accumulated at the fraction of d 1.04-1.21 g/ml. Unesterified cholesterol was found in the fraction of d 1.04-1.21 g/ml. ApoC was recovered predominantly in fractions of d 1.04-1.21 (50-60%) and d > 1.21 g/ml (30-40%). Cholesteryl esters were associated with VLDL during the hydrolysis of 50-70% of the triglycerides, but with advanced lipolysis, appeared in higher densities, mainly d 1.019-1.04 g/ml. The fraction of d 1.04-1.21 g/ml, (containing phosphatidylcholine, sphingomyelin, unesterified cholesterol, and apoC) contained by negative staining, many disk-like structures. The study demonstrated that removal of surface constituents (phospholipids, unesterified cholesterol, and apoC) during lipolysis of VLDL is an intrinsic feature of the lipolytic process, and is independent of the presence of plasma. It also indicated that surface constituents may be removed in a particulated form.
The Caco-2 cell monolayer: usefulness and limitations.

BACKGROUND The Caco-2 monolayer has been used extensively for the high-throughput screening of drug permeability and identification of substrates, inhibitors, and inducers of intestinal transporters, especially P-glycoprotein (P-gp). Traditionally, the Caco-2 monolayer is viewed as a single barrier rather than a polarized cell monolayer consisting of metabolic enzymes that are sandwiched between two membrane barriers with distinctly different transporters. OBJECTIVE This review addressed the usefulness and limitations of the Caco-2 cell monolayer in drug discovery and mechanistic studies. METHODS This mini-review covered applications of the Caco-2 monolayer, clarified misconceptions, and critically addressed issues on data interpretation. CONCLUSION The catenary model extends the usefulness of Caco-2 monolayer and provides proper mechanistic insight and data interpretation.
Specific Impairment in Developmental Reading Disabilities

Children with developmental reading disabilities (RD) frequently display impaired working memory functioning. However, research has been divergent regarding the characteristics of the deficit. Our investigation addressed this controversy by assessing Baddeley's working memory model as a whole rather than focusing on particular aspects of it, as has been done by much of the research to date. Participants included 20 children with RD and 20 typical readers between the ages of 9 and 13. The phonological loop, visual—spatial sketchpad, and central executive were assessed according to Baddeley's model. The results demonstrated that children with RD have an impaired phonological loop but intact visual—spatial sketchpad and central executive functioning as compared to controls. In terms of the phonological loop, the deficit appears to be specific to the phonological store. Furthermore, our research supports a relationship between phonological processing and phonological loop functioning.
Isolation and enumeration of circulating endothelial cells by immunomagnetic isolation: proposal of a definition and a consensus protocol

Summary. Background: Circulating endothelial cells (CECs) have been identified as markers of vascular damage in a variety of disorders, such as myocardial infarction, vasculitis, and transplantation. CD146‐driven immunomagnetic isolation has gained widespread use, but the technique is hampered by the lack of a definition of CECs and the absence of a consensus for their enumeration. Aim: To evaluate several variables influencing immunomagnetic isolation of CECs, formulate a definition for CECs and propose a consensus protocol for their enumeration. Methods: We devised a protocol based on CD146‐driven immunomagnetic isolation and a subsequent confirmatory step with Ulex‐Europaeus‐Lectin‐1 staining. In a multi‐center effort, we evaluated the preanalytical and analytical phases of this protocol. We evaluated the effects of storage, anticoagulation and density centrifugation, and compiled previous experience with this technique. Results: Our protocol permitted unequivocal identification of CECs with acceptable reproducibility. There was an effect of storage time in that median cell numbers declined to only 87.5% of their baseline values during 24 h of storage at 4 °C. Recovery was lower with citrate than with ethylene‐diamine tetra‐acetic acid after 4 h of storage; density centrifugation was also associated with lower recovery. We provide a comprehensive list of technical recommendations and potential pitfalls. Finally, based on our experience with this protocol and a recent consensus workshop, we formulated a working definition for CECs. Conclusion: Our work represents an important step toward consensus regarding the CECs. Our recommendations represent the experience of three major centers and should now be scrutinized by others in the field.
Caffeine Oxidation in Water by Fenton and Fenton-Like Processes: Effects of Inorganic Anions and Ecotoxicological Evaluation on Aquatic Organisms

A degradacao de cafeina pelo reagente de Fenton (Fe(II)/H2O2) e pelo reagente de Fenton modificado (Fe(III)/H2O2) foi investigada em agua deionizada em uma concentracao inicial de 5,2 μmol L-1 (1000 μg L-1). Esses dois processos de oxidacao diferentes foram comparados e foi observado que uma degradacao eficiente de cafeina (95%) foi promovida pelo reagente de Fenton na razao molar de Fe(II)/H2O2 de 3:10 apos 30 min. O efeito dos ions cloreto, sulfato e carbonato na decomposicao de cafeina pelo reagente de Fenton e pelo reagente de Fenton modificado foi investigado. Tambem foi avaliada a toxicidade cronica dos produtos de degradacao de cafeina sobre organismos aquaticos apos tratamento da solucao contendo inicialmente cafeina pelo reagente de Fenton usando a razao molar de Fe(II)/H2O2 de 3:10. Apenas quando Ceriodaphnia dubia foi exposta a concentracao de 100% v/v dessa solucao obtida apos o tratamento de cafeina pelo reagente de Fenton usando uma razao molar de Fe(II)/H2O2 de 3:10, toxicidade cronica sobre o microcrustacio avaliado foi observada.
Magnetoelectric Effect in $L 1_{0}$-CoPd Thin Films

The effect of an applied electric field on the magnetic properties of L 10-ordered CoPd thin films is investigated by first-principle calculations. Both the magnetic moment and the magnetocrystalline anisotropy of the surface atoms are changed by the electric field, but the net effect depends on the surface termination. The magnetocrystalline anisotropy switches from in-plane to perpendicular in the presence of external electric field. Typical magnetic-moment changes are 0.1 μB per eV/Å. The main mechanism is the shift of the Fermi level, but the anisotropy change also reflects a crystal-field change due to incomplete screening.
Hedgehog, Patched and Dispatched near the basement

Cell signaling is arguably the most important characteristic of multicellular organisms. Without cell signaling, the different cells in the body of a plant or animal could not communicate with each other, and they could not coordinate their actions. Such coordination is essential: first, to build a complex body composed of thousands or millions of cells and second, for the correct performance of such a body in everyday life, whether acquiring nutrients, excreting toxins, or dealing with hostile or friendly interactions from other organisms. This coordination is corroborated by the many problems and diseases (such as developmental abnormalities and cancers) that arise from malfunction of the cellular machinery that deals with cell signaling and communication (1–3). Thus, the study of such cell signaling machinery is receiving a great deal of attention by biological and medical research. At the most basic level, any cell signaling process must involve a signal, synthesized or otherwise, generated by the sending cell and some kind of system to receive that signal and respond to it in the receiving cell. An article by Callejo et al. (4) in PNAS sheds light on the first aspect of the process by providing crucial information on the mechanism for the release and transport of the signaling protein Hedgehog (Hh). Their findings show that a crucial step in Hh signaling is trafficking and recycling within the sending cell itself. Their findings, however, resonate with and are relevant to research on other signaling proteins.
Effect of repeated oestrogen administration on oestrous behaviour in ovariectomized ewes.

The effects or repeated injections of estradiol benzoate on the behavioral estrous responses of ovariectomized ewes were studied in a pool of 144 animals. Estradiol 15.6-424.2 mcg injected at intervals of 4 or 6 days produced a gradual decrease in the number of ewes showing induced estrous behavior. The proportion eventually fell below 10% when the ewes were defined as refractory to estrogenic stimulation of be havioral estrus. When a continuous variable was used as a measure of response an immediate effect was observed; after the 2nd injection of estradiol the duration of estrous behavior decreased by 14.3 hours (28%) while the time to onset of estrous behavior showed a corresponding increase by 5.2 hours (31%) when compared with the 1st injections. The proportion of ewes responding remained unaltered however indicating that continous variables are a more sensitive measur e of refractoriness. Treatment of refractory ewes with the progestagens progesterone SC-9880 or Nilevar restored normal estrous behavior. These results were interpreted to mean that estrogens (15-400 mcg) act to increase thresholds for subsequent estrogen stimulation of behavioral estrus while progestagens (1-10 mg) act to decrease this threshold. (AUTHORS MODIFIED)
Comparison of epinephrine and Shen‐Fu injection on resuscitation outcomes in a porcine model of prolonged cardiac arrest

Background Epinephrine has been used as a first‐choice vasopressor drug for cardiac arrest (CA) since 1974. However, the administration of epinephrine is controversial. This study aims to compare the effects of Shen‐Fu injection (SFI) and epinephrine on resuscitation outcomes in a porcine model of prolonged CA. Methods Ventricular fibrillation (VF) was electrically induced. After 8 minutes of untreated VF and 2 minutes of chest compressions, 24 pigs were randomly divided into 3 groups (n=8 per group): central venous injection of SFI (SFI group), epinephrine (EPI group), or saline solution (SA group). The haemodynamic status and oxygen metabolism parameters, including cardiac output, mean arterial pressure, left ventricular dp/dtmax and negative dp/dtmax, oxygen delivery (DO2), and oxygen consumption (VO2), were calculated. Results SFI shortened the time to restoration of spontaneous circulation (ROSC) and decreased the number of shocks, similar to epinephrine. However, the mean arterial pressure, cardiac output, left ventricular dp/dtmax and negative dp/dtmax were significantly higher in the SFI group than in the EPI group at 4 and 6 hours after ROSC. VO2 and ERO2 decreased after ROSC and then increased. VO2 and ERO2 were significantly higher in the SFI group than in the EPI and SA groups after ROSC, while those were lowest in the EPI group among all groups. Conclusions SFI shortened the time to ROSC and decreased the number of shocks, similar to epinephrine. However, SFI improved oxygen metabolism, and produced a better hemodynamic status compared with epinephrine. SFI might be a potentially vasopressor drug for the treatment of CA.
Subjective memory complaints, mood, and memory deficits among HIV/AIDS patients in Hong Kong

Diagnosis of HIV-associated neurobehavioral disorders often heavily relies upon patient complaints of cognitive difficulties. Yet, research in North America suggests that such complaints may be heavily influenced by affective factors. However, no work in this area has been done in China. The present study examined the relationships among depressed mood, anxiety, memory performance and subjective memory complaints among HIV/AIDS patients in Hong Kong. A total of 90 individuals with HIV were administered the Beck Depression Inventory (BDI), State–Trait Anxiety Inventory, Patient's Assessment of Own Functioning Inventory (PAOF), and Hong Kong List Learning Test. Forward regression analysis indicated that the BDI Cognitive-Affective score was the most significant predictor of subjective memory complaints on the PAOF. Furthermore, present results also supported previous findings that some individuals with HIV infection are more “accurate” than others in the self-appraisal of their memory ability. Given inaccuracies that exist in subjective memory complaints, these findings highlight the importance of comprehensive cognitive assessment when evaluating the neuropsychological status of individuals of HIV.