Extraction and Characterization of Mucilage from Cassia fistula Seeds

In the present era, polymers from natural sources become a better alternate for delivery of various kinds of drugs. The compliance and use of polymers obtained from natural origin are increasing day by day in the pharmaceutical industries due to a fewer side effects. Mucilages obtained from natural sources are a better alternative for designing and development of mucoadhesive drug delivery system. Due to the mucoadhesive property, the mucilage may also be used for various purposes such as emulsifying agent, suspending agent, bio-adhesive agent, matrix forming agent and controlled release. Some properties of mucilage like biodegradable in nature, nontoxic, less expensive and free availability make them better excipients for different dosage form. The modifications in the mucilage make them to compete with the synthetic products that are commercially available in the market. In the present research work, we have carried out the extraction and characterization of mucilage obtained from Cassia fistula seeds. Further we have also carried out organoleptic parameters, Micromeritic study, particle size, swelling index etc for the extract. On the basis of these parameters we can conclude that Cassia fistula seed extract will be a better alternative for designing and development a mucoadhesive dosage form. Commonly the mucilage is used as an adjuvant in the drug delivery system. Mostly the naturally extracted gums variety of pharmaceutical preparations. Now a day the are biodegradable and non- toxic, which posses a researchers are giving special focus on the extraction of property of hydration and get swell when they come on the mucilage from various natural sources. The natural contact with the aqueous media, this makes them suitable mucilage has various advantages over synthetic for the development and preparation of dosage form. materials like they are non-toxic, non-irritating and There are so many researches available using various emollient are available at low cost (1). The mucilage natural sources for the extraction and characterization of extracted from the plant has great importance in the mucoadhesive components. The well known examples of pharmaceutical industry due to the presence of mucilage extracted from plants are acacia, tragacanth, polysaccharide. Mucilage may be use for various gum kraya, gum ghati etc. Natural polymers play a key role properties like gelling agent, suspending agent, as pharmaceutical excipients. The wide range of their disintegrating agent, stabilizing agents in different types bio-compatibility with drug and other materials make of pharmaceutical formulation etc. The mucoadhesive them important to be used as pharmaceutical excipients. agents also can be used to provide the sustained and Their easily availability and economic reliability also controlled release action for the formulations. Commonly makes them a choice for pharmaceutical excipient. In the the method used for the fabricating drugs in controlled present study, extraction, phytochemical screening and release pharmaceutical formulation is by incorporating characterization of Cassia fistula seed mucilage has been them with the matrix having hydrophilic rate controlling carried out. The extract obtained from the Cassia fistula natural polymers. Presently many researches are going on seed has been used as a mucodhesive component in the use and application of naturally occurring present research (1). designing of various dosage form for controlled release