Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Place Image in Business Location Decisions

The location where businesses choose to locate or re-locate their businesses, also known as site selection, is an important policy matter for economic development practitioners and academics since significant amount of resources are spent in this area. As places spend a great deal of public dollars marketing their city, region, and state to potential investors and businesses, private sector dollars from business invest a significant amount on land, labor, and capital to get these new facilities and sites up and running. To date, most of the literature as it relates to place image and business site selection decisions examine traditional factors related to the decision-making process. This dissertation presents exploratory research which for the first time summarizes this multi-disciplinary literature and deconstructs its five components into: brand, visual image, reputation, sense of place, and identity. Beyond this, this research continues to open the scholarly conversation on how locations are advertised and sold and how this marketing can affect where businesses locate their headquarters. Using a literature review, interviews, grounded theory, a survey of professionals in the field of site selection, and an analysis of the five components of place image using structural equation modeling, this research quantitatively investigates the association of place image on site selection of headquarters. In all, the analysis found that brand, visual image, and reputation have a positive effect on place image. And place image had a positive direct effect on site selection decision. Also, brand and reputation showed a stronger effect in east and west coast states, and reputation was more important for small and medium sized
Methamphetamine Abuse in the United States

Emerging behavioral research on methamphetamine suggests a growing public health concern no longer limited to specific regions of the United States. Given that current evidence-based treatments for addressing methamphetamine addiction have had limited success, there remains a need to further examine the efficacy of these approaches. Here, we synthesize the psychological research literature regarding the prevalence and correlates of methamphetamine use across all segments of the US population, analyze the role that use of the drug plays in relation to sexual risk-taking and consider implications for therapeutic interventions to address this drug addiction.
Recall, recognition, and rate: memory and the heart.

Heart rate (HR) changes during recall and recognition tasks were related to memory load and performance. Current hypotheses imply that heart rate acceleration may indicate the processing of stored information, and, thus relate to task performance. Twenty volunteers performed a recognition task with memory set size varying between five and ten items. The task was divided into input, retain, and test periods. Eight volunteers performed a recall task which was identical except for the form of the memory test. Consistent HR changes showed a deceleration prior to each task period which was followed by acceleration. HR was not influenced by memory load, but did show a small but consistent relationship to performance. In both recall and recognition experiments relatively greater acceleration in the retain period was associated with more accurate memory performance. Similar but less clear effects occurred during information input. In this period degree of deceleration also appeared related to recognition performance. Results were related to previous concepts of HR and attention rather than processes specific to memory.
Africa human development report 2012: towards a food secure future

Yet sub-Saharan Africa has ample agricultural land, plenty of water and a generally favourable climate for growing food. And in the last 10 years many African countries posted world-beating economic growth rates and became among the fastest movers on the Human Development Index. This first Africa Human Development Report seeks to understand the deeper causes behind these two jarring paradoxes and explores options for unleashing an era of mutually reinforcing advances in food security and human development.
Calcul d'itinéraire multimodal et multiobjectif en milieu urbain. (Multimodal and multiobjectif route computation in urban areas)

Par conscience environnementale ou a cause des couts de l'energie, de plus en plus de personnes utilisent les transports en commun ou les transports doux. Cependant, un seul mode de transport ne peut pas couvrir tous les besoins. De ce fait, la combinaison de differents modes de transport est une solution tres interessante. Trouver le meilleur chemin multimodal pour une personne donnee est une tâche difficile. Chaque personne a des preferences differentes concernant la duree, le cout, la pollution, les changements, etc. De plus, le choix d'un meme usager dependent des circonstances. S'il pleut, il ne prendra pas le velo et s'il a des bagages encombrants, il evitera les changements. L'optimisation multiobjectif permet de proposer plusieurs solutions dites equivalentes. Ainsi l'utilisateur choisira l'itineraire qui lui convient en fonction de ses preferences a un moment donne. Le probleme principal a resoudre est donc celui du plus court chemin multiobjectif de point a point dependant du temps. L'enjeu est d'etre capable d'avoir des resultats de l'ordre de la seconde pour une grande ville pour envisager une application reelle. Une attention particuliere a ete portee sur la simplicite et la genericite des approches proposees. Nous ne nous restreignons pas a un nombre predefini de modes de transport ou d'objectifs. Plusieurs algorithmes reputes pour leurs performances theoriques ou experimentales ont ete adaptes au cas multiobjectif ou a la dependance du temps. Nous avons egalement propose des heuristiques permettant de garder le temps de calcul de l'ordre de la seconde.
Informing family approaches to eating disorder prevention: perspectives of those who have been there.

OBJECTIVE The study explored how aspects of the family environment may relate to the onset of eating disorders. METHOD Semi-structured interviews were conducted with 27 individuals currently receiving treatment for eating disorders. Data were analyzed using principles of content analysis. RESULTS Eight themes emerged regarding recommendations for families to prevent the onset of eating disorders: (1) Enhance parental support; (2) Decrease weight and body talk; (3) Provide a supportive home food environment; (4) Model healthy eating habits and physical activity patterns; (5) Help your children build self-esteem beyond looks and physical appearance; (6) Encourage appropriate expression of feelings and use of coping mechanisms; (7) Increase your understanding of eating disorder signs and symptoms; and (8) Gain support in dealing appropriately with your own struggles. DISCUSSION Our results can be utilized to generate new theoretical insights as to how parents can raise children with healthy weight-related attitudes and behaviors.
Analysis of the Brillouin gain spectrum in a graded-index multimode fiber

We present a numerical method for computing the Brillouin gain spectrum (BGS) in a graded-index multimode fiber (GI-MMF). The BGS is shown to strongly depend on the pump and probe modal content. In particular, the peak frequency of the BGS, usually referred as Brillouin Frequency Shift (BFS), as well the BGS bandwidth, vary dramatically with the order of the optical modes interacting along the fiber.
A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.

BACKGROUND The survival rate of patients with head and neck squamous cell carcinoma (HNSCC) stands at approximately 50% and this has not improved in decades. This study developed a novel sirtuin-3 (SIRT3) inhibitor (LC-0296) and examined its role in altering HNSCC tumorigenesis. MATERIALS AND METHODS The effect of the SIRT3 inhibitor, LC-0296, on cell survival, proliferation, and apoptosis, and reactive oxygen species levels in HNSCC cells were studied. RESULTS LC-0296 reduces cell proliferation and promotes apoptosis of HNSCC cells but not of normal human oral keratinocytes. This inhibitory effect is mediated, in part, via modulation of reactive oxygen species levels. Additionally, LC-0296 works synergistically to increase the sensitivity of HNSCC cells to radiation and cisplatin treatment. CONCLUSION Development of novel SIRT3 inhibitors, such as LC-0296, might enable the development of new targeted therapies to treat and improve the survival rate of patients with head and neck cancer.
USE OF INFORMATION TECHNOLOGY IN BUSINESS PROCESS IN PAKISTANI AND MULTINATIONAL PHARMACEUTICALS IN KORANGI

This study presents an analysis of IT use and Business Processes (BP) in Korangi pharmas. Information system usage and manufacturing performance are moderately associated within the sample. There is little difference in the utilization of IT between the multinational and Pakistani firms. The main deficiency of utilization are in decision support systems and external integration functions. Suggestions are presented for increasing effectiveness of IT use in business process.
The Composition, Functions, and Regulation of the Budding Yeast Kinetochore

The propagation of all organisms depends on the accurate and orderly segregation of chromosomes in mitosis and meiosis. Budding yeast has long served as an outstanding model organism to identify the components and underlying mechanisms that regulate chromosome segregation. This review focuses on the kinetochore, the macromolecular protein complex that assembles on centromeric chromatin and maintains persistent load-bearing attachments to the dynamic tips of spindle microtubules. The kinetochore also serves as a regulatory hub for the spindle checkpoint, ensuring that cell cycle progression is coupled to the achievement of proper microtubule–kinetochore attachments. Progress in understanding the composition and overall architecture of the kinetochore, as well as its properties in making and regulating microtubule attachments and the spindle checkpoint, is discussed.
Molecular characterisation of a 3.5 Mb interstitial 14q deletion in a child with several phenotypic anomalies

Interstitial deletions of the long arm of chromosome 14 are infrequent. Molecular and clinical studies on patients with deletions involving 14q11.2-q21 have recently been reported.1 Most of these deletion patients share common clinical signs, such as midline defects of the central nervous system, feeding problems, growth abnormalities, hypotonia, developmental delay, mental retardation, and craniofacial anomalies.1 Here we present the phenotypic, cytogenetic, and molecular genetic findings of a 2½12 year old boy with a 14q12-q13.1 deletion. To our knowledge this is the second case described of a patient with a deletion of less than 3.5 Mb within chromosome bands 14q12-q13.1. Using the genomic sequence between markers D14S1060 and D14S286, we have constructed a transcription map of the genomic interval deleted in our patient. Our proband (fig 1) is the 40 week product of a second, uncomplicated pregnancy and delivery. Maternal age was 27 years. Birth weight was 4435 g (>90th centile), length 55 cm (>90th centile), and head circumference 34 cm (10th-25th centile). Apgar score was 7/9/10. The neonatal period was complicated by pneumonia, treated with parenteral antibiotic therapy over 10 days. Besides relative microcephaly, hypertelorism, epicanthic folds, a long and flat philtrum, hypodontia, laterally placed, hypoplastic mamillae, second degree hypospadias, bifid scrotum, and bilateral cryptorchidism were noticed. Cranial ultrasound was normal; ultrasound of the kidneys and pelvic region showed bilateral second degree hydronephrosis, and both testes were visible in the inguinal region. Screening for connatal infections (toxoplasmosis, rubella, cytomegalovirus, and parvovirus B19) was negative. Psychomotor development was severely impaired from early infancy. Lack of vision was evident at 3 months and, apart from head control, no gain of motor milestones or social contact was achieved until the age of 29 months. Muscle tone of the trunk was decreased while it was increased and dystonic in the upper and …
Letter: metabolic syndrome in patients with coeliac disease on a gluten‐free diet

management strategies that combine corticosteroids (with or without azathioprine) and ursodeoxycholic acid. 8 The experience of Drs Yilmaz and Dayanan suggests that immunosuppressive therapy alone may be effective as an anti-fibrotic regimen in some patients. Furthermore, outcomes may be better than in those with classical AIH or PBC. The overlap syndromes are clinical descriptions based largely on clinical judgments, and the AIH/PBC overlap syndrome described by Drs Yilmaz and Dayanan exists within a clinical spectrum that is bounded by patients with mainly AIH and weak manifestations of PBC and by patients with mainly PBC and inflammatory features reminiscent of AIH. Immunosuppressive therapy has a role across the spectrum, but outcomes may differ depending on the predominant component. The absence of relapse after drug withdrawal suggests that PBC may have been the predominant disease in this experience. The observations of Drs Yilmaz and Dayanan indicate that immunosuppressive therapy can have anti-fibrotic effects in immune-mediated liver diseases outside the classical phenotype of AIH. Future objectives must be to characterise those patients who are likely to respond, validate non-invasive methods to monitor fibrosis, and rigorously evaluate site-specific anti-fibrotic interventions that might supplement or replace current strategies. ACKNOWLEDGEMENT The author’s declarations of personal and financial interests are unchanged from those in the original article.
Caregiver burden, time spent caring and health status in the first 12 months following stroke

Objective: To quantify time caring, burden and health status in carers of stroke patients after discharge from rehabilitation; to identify the potentially modifiable sociodemographic and clinical characteristics associated with these outcomes. Methods: Patients and carers prospectively interviewed 6 (n = 71) and 12 (n = 57) months after discharge. Relationships of carer and patient variables with burden, health status and time analysed by Gaussian and Poisson regression. Results: Carers showed considerable burden at 6 and 12 months. Carers spent 4.6 and 3.6 hours per day assisting patients with daily activities at 6 and 12 months, respectively. Improved patient motor and cognitive function were associated with reductions of up to 20 minutes per day in time spent in daily activities. Better patient mental health and cognitive function were associated with better carer mental health. Conclusions: Potentially modifiable factors such as these may be able to be targeted by caregiver training, support and education programmes and outpatient therapy for patients.
Eco-epidemiology of Bovine Tuberculosis (bTB) in an African savanna : The conflict between traditional pastoralist adaptations and disease transmission in the modern era

Bovine tuberculosis (bTB) is a zoonotic disease, and remains a cause of concern for livestock, wildlife and human health, especially in Ethiopia. It is a contagious disease, so close contact between animals or sharing of feed between infected and non-infected animals are major risk factors for transmission. Thus, improving the understanding of the factors that promote contact between hosts (i.e., livestock animals but also wild ruminants) is critical for limiting bTB transmission in pastoral, multi-host communities. I found that the older the age of the cattle and the lower the body condition, the higher the chance of a positive bTB test result at the individual animal level. Moreover, at herd level, herd size, contact with wildlife, and the interaction of herd size and contact with wildlife were identified as significant risk factors for bTB prevalence in cattle in Ethiopia. Further to what is already known from the past studies, I found that the probability of contact with wildlife was positively influenced by herd size, through herd movement. As larger herds moved more and grazed in larger areas, the probability of grazing in an area with wildlife and contact with either infected cattle or infected wildlife hosts increased; this also increased the chances for bTB infection. I detected a possible ‘dilution effect’ in bTB, where a higher evenness of mammal species reduced the probability of bTB occurrence. This dilution effect might be caused by encounter reduction. Because the encounter rate is proportional to the distribution of the host species; evenness would then capture the probability of encounter between pathogens and each host species. Thus, species evenness can be an appropriate measure of biodiversity to explain disease risk. I also showed that bTB prevalence was positively associated with the invasion of the plant Prosopis (Prosopis juliflora), maybe due to the loss in host species evenness and the increase in cattle movement as a consequence of the loss of palatable grasses in Prosopis-infested areas. Moreover, social contacts between herd owners are also important, as I found that herds with a greater number of edges in a (social) network had more connections in the livestock transfer network, increasing the probability of becoming infected with bTB. Thus, cultural components like large herd size and social contacts are at odds with the global One Health rationale to reduce bTB.
Pancreatic islet autotransplantation for nonmalignant and malignant indications

The standard therapy for patients with chronic pancreatitis (CP) and severe abdominal pain is total pancreatectomy (TP) followed by islet autotransplantation (IAT) to prevent the development of brittle diabetes. In adult patients, narcotic independence is achieved in up to 73% of patients 1 to 5 years after transplantation whereas insulin independence is achieved in up to 40% of patients 1 to 2 years after transplantation. Pediatric patients have shown similar outcomes for narcotic independence (up to 79%) but better outcomes for insulin independence (up to 56% 1 year after transplantation). The quality of life of both adult and pediatric patients improved significantly after TP‐IAT using the Medical Outcomes Study SF‐36 survey. IAT after pancreatectomy is also performed for patients with benign and malignant disease of the pancreas. The limited studies in this patient population suggest that IAT may be potentially beneficial for carefully selected patients when sufficient numbers of islet cells can be isolated. Further studies involving a larger number of patients are needed to determine the risks and benefits of IAT in patients with malignancy. The feasibility of IAT depends on the availability of a laboratory that can isolate the pancreatic islet cells. An on‐site laboratory is the traditional model; however, remote processing of pancreatic islets has been reported to result in successful outcomes. This review discusses the outcomes of adult and pediatric autologous pancreatic islet cell transplantation for CP and pancreatic tumors as well as laboratory processing of pancreatic islet cells.
Identification of Regions in Alleles of the Flax Rust Resistance Gene L That Determine Differences in Gene-for-Gene Specificity

Thirteen alleles (L, L1 to L11, and LH) from the flax L locus, which encode Toll/interleukin-1 receptor homology–nucleotide binding site–leucine-rich repeat (TIR-NBS-LRR) rust resistance proteins, were sequenced and compared to provide insight into their evolution and into the determinants of gene-for-gene resistance specificity. The predicted L6 and L11 proteins differ solely in the LRR region, whereas L6 and L7 differ solely in the TIR region. Thus, specificity differences between alleles can be determined by both the LRR and TIR regions. Functional analysis in transgenic plants of recombinant alleles constructed in vitro provided further information: L10–L2 and L6–L2 recombinants, encoding the LRR of L2, conferred L2 resistance specificity, and an L2–L10 recombinant, encoding the LRR of L10, conferred a novel specificity. The sequence comparisons also indicate that the evolution of L alleles has probably involved reassortment of variation, resulting from accumulated point mutations, by intragenic recombination. In addition, large deletion events have occurred in the LRR-encoding regions of L1 and L8, and duplication events have occurred in the LRR-encoding region of L2.
Using Information Resources to Innovate Service Business Model

With large data, cloud computing, the Internet + these new information technology concepts, many companies or scholars have begun to pay attention to information technology business model innovation. They spend a lot of manpower, material and financial resources to build a new information technology, but most people have ignored the information resources themselves. This paper introduces the concept of information resource and service business model, and illustrates the specific flow of information resources promote business model innovation. Finally, the case of Wechat Business and Didi Taxi is used to illustrate how information resources promote business model innovation. Enterprises or the masses can learn the value of information resources through these cases.
HiLog as a Platform for Database Languages

We argue that predicate calculus is not sufficient as a basis for the next generation of database languages. To fill in the gap, we propose a novel logic, called HiLog, which can be viewed as an extension of predicate calculus. The distinctive feature of HiLog is its higher-order syntax which makes it possible to manipulate the database with greater ease. However, the semantics of this logic is essentially first-order, which makes it possible to define a resolution-based proof procedure for HiLog. We then go on and compare HiLog with two other well-known database languages, COL and LDL, arguing that HiLog eliminates some of the problems in these languages caused by their second-order semantics. Finally, we discuss the utility of HiLog as a platform for implementing object-oriented database languages.
Antimonotonicity and Chaotic Dynamics in a Fourth-Order Autonomous nonlinear Electric Circuit

In this paper we study the dynamics of a fourth-order autonomous nonlinear electric circuit with two active elements, one linear negative conductance and one nonlinear resistor with a symmetrical piecewise-linear v–i characteristic. Using the capacitances C1 and C2 as the control parameters, we observe the phenomenon of antimonotonicity and the formation of "bubbles" in the development of bifurcations, resulting typically in reverse period-doubling sequences. We also find a crisis-induced intermittency, when the spiral attractor suddenly widens to a double-scroll attractor. We have plotted several bifurcation diagrams of reverse period-doubling sequences and computed the scaling parameter δ versus the control parameter C2 for the different regimes, where bubbles evolve. Thus, besides the usual Feigenbaum constant δ → δF = 4.6692…, we also observe, in some cases, a convergence of δ to , as expected from theoretical considerations. Finally, by plotting a return map associated with one of the state variables, we demonstrate the strongly one-dimensional character of the dynamics and discuss the dependence of this map on the parameters of the system.