Miracle-dz/UniFAR-FTUs huggingface dataset:
Management of granite rocks

This paper discusses the possible goals of management of granite rocks in terms of the values associated with them and the sensitivity of different values to use. It is suggested that they may be viewed as rock islands. Many of the contrasting values are shared between the individual rocks and the surrounds e.g. picnic sites, but such contrasting habitats are not equally tolerant of disturbance. Problems associated with management are diverse and the task of managing rocks cannot be reduced to simple recipes. This paper sets out the difficult management problems which have to be resolved because of conflicts arising from the very disparate values attributed to rocks by different groups, and concludes that adequate management will depend on public cooperation based on an informed awareness of the diverse values attributed to rocks.
The Use of Different Commercial Mineral Water Brands to Produce Oil-In-Water Nanoemulsions

Nanoemulsions are submicron-size colloidal systems that have the ability to encapsulate, protect, and deliver active ingredients. They have been used in the pharmaceutical, cosmetics, and food industries to improve the absorption of drugs by the skin or via the gastrointestinal tract, aide in food conservation, and treat skin problems. To proper formulate a nanoemulsion, it is important to know the characteristics of its components (aqueous and oil phases, surfactants and additives), as well as the influence on the production method that will be used. This study investigates the influence of aqueous phase composition, stability and particle size in an oil-and-water nanoemulsion formation. By using a low energy method, the purified water was exchanged for different commercial mineral water and saline solutions, and the results of stability, particle size, pH and conductivity tests, were compared. These results show that the minerals present in commercial waters may alter the particle size, pH and conductivity values of nanoemulsions, as well as their stability.
3D Simplification Methods and Large Scale Terrain Tiling

This work was funded by the Executive Agency for Small and Medium-sized Enterprises (EASME), European Maritime and Fisheries Fund (EMFF), European Union, under the project EASME/EMFF/2016/005 High resolution seabed mapping. R. Garcia was partly funded by the Spanish Government under project CTM2017-83075-R
Expression of the Insecticidal Protein Gene cry1C of Bacillus thuringiensis in Plant-Colonizing Nitrogen-Fixing Bacteria

The NMO10 bacterial isolate was isolated from the rhizosphere of cotton plants. This isolate showed high potentiality to fix nitrogen and a high ability to colonize the phyllosphere of cotton plants. Based on this, plasmid pHTNC3 harboring the cry1C gene was used to transform NMO10. The transformed bacterial isolate (tNMO10) had a dual action both in the biocontrol of the Lepidopteron insect Spodoptera littoralis and as a bio-fertilizer. The presence of an expressed 135 kDa Cry1C protein in the protein pattern of tNMO10, microscopic examination of the bipyramidal crystals that characterize the Cry1C protein and immuonoblot analysis indicated efficient expression of the cry1C gene in the heterologous host NMO10. Bioassays against the neonate larvae of the cotton leaf worm S. littoralis revealed that the protein preparations from the tNMO10 were toxic. _____________________________________________________________________________________________________________
The Peroxisome Proliferator-Activated Receptor γ Agonist Pioglitazone Protects Vascular Endothelial Function in Hypercholesterolemic Rats by Inhibiting Myeloperoxidase

Objective Hypercholesterolemia- (HC-) induced endothelial dysfunction is the first step of atherogenesis, and the peroxisome proliferator-activated receptor γ (PPARγ (PPARγ (PPARγ) has been reported to attenuate atherosclerosis formation; however, the underlying mechanisms are not fully understood. The present study was designed to determine whether myeloperoxidase (MPO) mediates HC-induced endothelial dysfunction and the role of the PPARγ agonist pioglitazone (PIO) in attenuating endothelial dysfunction. Methods Male Wistar rats were fed with normal or high cholesterol diets for 8 weeks. HC rats were randomized to receive dapsone (DDS, the MPO inhibitor) during the last 6 days or PIO for the remaining 4 weeks. Vascular endothelial function was determined by comparing vasorelaxation to ACh, an endothelium-dependent vasodilator, and SNP, an endothelium-independent vasodilator in vascular rings in vitro. The vascular MPO activity, NOx content, and cGMP level were measured by the MPO activity assay kit, NO assay kit, and cGMP RIA kit. Results Compared with rats fed with normal diet, endothelium-dependent vasodilation, NOx content, and cGMP level were decreased, and MPO activity was increased in thoracic aortas of rats fed with HC diet. There was a negative correlation between vascular endothelial function, NOx content or cGMP level, and MPO activity. PIO obviously reduced the MPO activity, increased NOx content and cGMP level, and improved endothelium-dependent vasodilation function in HC rats, which was essentially the same as that seen with DDS. And, there was a negative correlation between vascular endothelial function, NOx content or cGMP level, and MPO activity in the HC group and the PIO intervention group. Conclusion MPO might provoke vascular endothelial dysfunction in hypercholesterolemic rats by reducing the NO biological activity and impairing the NO/cGMP/cGK signaling pathway. PIO might inhibit vascular MPO activity and increase NO bioavailability with the net result of reversing endothelial dysfunction.
The austerity fuelled wave of contention in Croatia – myth or reality?

Analyses of protest dynamics in Croatia are rare, partially because until know it was not possible to view them systematically. Relying on the newly collected protest event data 2000-2017, this paper describes the main trends and dynamics of protest activities in Croatia in the observed period. it re-examines Beissinger and sasse's claim about the absence of austerity related protests in Croatia after 2008. The analysis shows that though protests directly addressing austerity were relatively scarce, when the protest set is expanded to protests which demanded free public education, advocated labour rights, and fought for the right to the city, the prevailing thesis about "quietism" in Croatia can be challenged. The paper aims to relate some of the observed protest dynamics to Kerbo's distinction between movements of crisis and movements of affluence. Focusing on the period between the student movement in 2008 until Facebook protests in 2011, it shows that the student movement and "The Right to the City" movement preceded Facebook protests in formulating and expressing socio-economic grievances and articulated anti-systemic sentiment. due to their strong organizational structure, resources and activists' "know-how", these movements resemble Kerbo's movements of affluence. on the other hand, the 2011 Facebook protests lacked organizational structure and continuous engagement and can be seen as movements of crisis.
THERMOWOOD AND GRANULARITY OF ABRASIVE WOOD DUST

The granular composition of the abrasive dust of heat-treated wood from spruce and oak depending on the treatment at the temperature of 160 °C, 180 °C, 200 °C and 220 °C is presented in the paper. The proportion of dust fractions with a dimension of ≤ 0.08 mm was determined by a sieve analysis. The percentage of these proportions is similar for natural wood and wood treated at the temperature of 160 °C, 180 °C and 200 °C. Significantly lower proportion of dust fractions with dimensions of ≤ 0.08 mm occurred at a temperature of 220 °C in all examined samples. The fact that the main factor causing the drop of the dust fraction with a dimension of ≤ 0.08 mm at 220 °C is the reduction in wood density is assumed.
Transmittance analysis of Silver selenide thin films

Silver selenide thin films of thickness between 80 nm and 160 nm were thermally evaporated at a high vacuum better than 10 mbar at a rate of 0.2nm/sec on well cleaned glass substrates. From XRD studies, Silver selenide thin films are found to be polycrystalline with orthorhombic structure. Transmittance studies of silver selenide thin films were recorded using UV-Vis spectrophotometer in the wavelength range between 300 nm and 900 nm. The absorption coefficients of silver selenide thin films were determined using Beer-Lamberts Law. From absorption coefficient value, it is confirmed that silver selenide exhibits direct band transition. The optical band gap of silver selenide thin films have been calculated from the recorded spectra and its value is found to be around 1.72 eV Please purchase PDFcamp Printer on http://www.verypdf. com/ to remove this watermark.
PPA_A_237778 97..105

Observia, Paris, France Background: Medication nonadherence is a global problem that requires urgent attention. Roughly half of all drugs that are prescribed for chronic treatments are not taken by the patients in question. Initiatives designed to support patients and help them modify their behavior are enhanced by personalization, and a number of profiling tools exist to help customize such interventions. Most of these tools were originally designed as paper-based questionnaires, but the growth of digital adherence technologies (DATs) illuminate the need for the development of digital profiling systems that can interact with fully automated patient interfaces. Objective: The objective of this study was to examine existing frameworks from medicine, psychology, sociology, consumer behavior, and economics to elaborate a comprehensive, quantitative profiling approach that can be used to drive the customization of patient support initiatives. Results: Building primarily on IcekAjzen’s Theory of Planned Behavior (TPB), the Health Belief Model (HBM) was used to inform the beliefs about behavior posited in the TPB, while incorporating established factors regarding self-efficacy in the “control” elements of the TPB and selected social and psychological factors in the other constituents of themodel. The resulting SPUR (Social, Psychological, Usage, Rational) framework represents a holistic, profiling tool with detailed, quantitative outputs that describe a patient’s behavioral risks and the drivers of that risk. Conclusion: An interactive, digital questionnaire built around SPUR represents a potentially useful tool for those desirous of building interactive digital support programs for patients with chronic diseases.
ALIGNED CARBON NANOTUBE REINFORCEMENT OF GRAPHITE/EPOXY PLY INTERFACES

A new interlaminar reinforcement for layered composite materials is presented utilizing aligned carbon nanotubes (CNTs) to bridge the matrix-rich region between advanced composite layers (plies). Fabrication of the CNTs and their incorporation via pattern transfer into a graphite/epoxy preimpregnated (prepreg) system to form a hybrid composite are described. The interfaces are characterized via optical and scanning electron microscopy which demonstrates excellent wetting of the aligned CNT forests by the epoxy in the prepreg. A first-order fracture mechanics model with a simple traction law indicates significant toughening via such aligned CNTs. Mode 1 fracture tests of the first-manufactured 'nanostitched' prepreg laminates shows a 160% improvement in critical strain energy release rate. Future work includes more detailed strength and fracture testing, including other modes, multifunctional property characterization and modeling, and refinement of the manufacturing process to create improved nanostitches.
Separation and Identification of the Active Ingredients in Piper nigrum L. Leaves and Analysis of Their Antioxidant Activity

(1.中国热带农业科学院香料饮料研究所,海南万宁 571533)(2.华中农业大学食品科技学院,湖北武汉 430070) (3.农业部香辛饮料作物遗传资源利用重点实验室,国家重要热带作物工程技术研究中心,海南万宁,571533) 摘要:胡椒果与叶都具有抗氧化活性,而叶还具有抗动脉粥样硬化功能,但胡椒叶的活性因子并不明确,另摘叶可以提高胡椒 产量,为给胡椒叶开发利用提供理论依据,本文用氧自由基清除能力(ORAC)方法评价了胡椒叶的抗氧化活性,结果表明胡椒叶 ORAC 值为 3639.05 μmol TE/g,高于胡椒果(胡椒鲜果、白胡椒和黑胡椒);通过系统溶剂提取法,确定了胡椒叶的乙醇提取物的 ORAC值最高;以ORAC 检测方法作为分离鉴定抗氧化活性物质的追踪方法,对胡椒叶乙醇提取物依次萃取和采用硅胶层析、凝胶 层析、反相层析、薄层层析及 HPLC 等方法分离纯化得到活性目标物,通过核磁共振和质谱等手段鉴定与表征,首次从胡椒中分离 得到两种具有较高抗氧化活性的扁柏脂素和野漆树苷,其 ORAC值分别为 16070 μmol TE/g和 10823 μmol TE/g。 关键词:胡椒;氧自由基清除能力 ORAC;扁柏脂素;野漆树苷 文章篇号:1673-9078(2015)2-63-69 DOI: 10.13982/j.mfst. 1673-9078.2015. 2.012
The Integration of Strategic Management and Intrapreneurship: Strategic Intrapreneurship from Theory to Practice

The concept of strategic intrapreneurship emerges through the combination of two potentials, namely intrapreneurship and strategic management. Strategic intrapreneurship help organizations seek to achieve strategic goals in order to discover innovations and take advantage of today's competitive advantages in the direction of its goals and objectives. Strategic intrapreneurs engage in strategic intrapreneurship in line with their core competencies to provide a sustainable competitive advantage for the enterprise. The main purpose of the study will be to present an approach to the strategic intrapreneurship model that emerges from the combination of entrepreneurship, strategic management and try to explain these concepts in a different approach with both qualitative and quantitative research methods. The quantitative study conducted in terms of strategic intrapreneurship, it is believed that the intrapreneurship and its dimensions show the behaviors of the intrapreneurship and dimensions of the workers are at a high level. The findings from SWOT analysis, which is qualitative research, show that the participants have high level of strategic intrapreneurship behaviors.
DDDT_A_235004 4413..4430

Mahmoud M Omar 1,2 Nermin E Eleraky Amani M El Sisi Omiya Ali Hasan 1Department of Pharmaceutics and Industrial Pharmacy, Deraya University, El-Minia, Egypt; 2Department of Pharmaceutics, Sohag University, Sohag, Egypt; 3Faculty of Pharmacy, Assiut University, Assiut, Arab Republic of Egypt; 4Department of Pharmaceutics and Industrial Pharmacy, Beni-Suef University, Beni-Suef, Egypt Background: Sumatriptan succinate (SUT) is a potent drug used for relieving or ending migraine and cluster headaches. SUT bioavailability is low (15%) when it is taken orally owing to its gastric breakdown and bloodstream before reaching the target arteries. Aim: The aim of the study was to enhance SUT bioavailability through developing an intranasal transferosomal mucoadhesive gel. Methods: SUT-loaded nanotransferosomes were prepared by thin film hydration method and characterized for various parameters such as vesicle diameter, percent entrapment efficiency (%EE), in vitro release and ex vivo permeation studies. The in-situ gels were prepared using various ratios of poloxamer 407, poloxamer 188, and carrageenan and characterized for gelation temperature, mucoadhesive strength, and rheological properties. Results: The prepared transferosomes exhibited percent entrapment efficiencies (%EE) of 40.41±3.02 to 77.47±2.85%, mean diameters of 97.25 to 245.01 nm, sustained drug release over 6 hours, and acceptable ex vivo permeation findings. The optimum formulae were incorporated into poloxamer 407 and poloxamer 188-based thermosensitive in-situ gel using carrageenan as a mucoadhesive polymer. Pharmacokinetic evaluation showed that the prepared in-situ gel of SUT-loaded nano-transferosomes gave enhanced bioavailability, 4.09fold, as compared to oral drug solution. Conclusion: Based on enhancing the bioavailability and sustaining the drug release, it can be concluded that the in-situ gel of SUT-loaded nano-transferosomes were developed as a promising non-invasive drug delivery system for treating migraine.
COPD_A_225365 2885..2893

*These authors contributed equally to this work Purpose: Alpha-1 antitrypsin deficiency is associated with the development of chronic obstructive pulmonary disease (COPD), whereas increased levels of serum alpha-1antitrypsin occur in response to inflammation. The effects of alpha-1 antitrypsin levels on the clinical course of COPD had been unclear. We investigated the association of serum alpha-1 antitrypsin levels with the clinical course of COPD patients based on data from a 10-year prospective cohort study. Patients and methods: We analyzed 278 COPD patients who participated in the Hokkaido COPD cohort study and who did not meet the criteria for alpha-1 antitrypsin deficiency. We divided the subjects into 3 groups according to quartiles of serum alpha-1 antitrypsin levels at baseline: lower group (<116 mg/dL, n = 66); middle group (116 to ≤141 mg/dL, n = 145); and higher group (>141 mg/dL, n = 67). The annual change in forced expiratory volume in 1 s (FEV1) and events of COPD exacerbation were monitored during the first 5 years, and mortality was followed-up during the entire 10 years. Results: At baseline, the higher group showed lower body mass index; higher computed tomography emphysema score; lower diffusing capacity; higher levels of acute-phase proteins; and higher blood neutrophil counts. Longitudinal analyses revealed that in the higher group, the annual decline in FEV1 was rapid and the 10-year mortality was higher, but there was no association between serum alpha-1 antitrypsin levels and time to first exacerbation. Conclusion: COPD subjects with higher serum alpha-1 antitrypsin levels were associated with a worse systemic inflammation status and higher 10-year mortality.
RHEOLOGY AS A POWERFULL TOOL FOR SCIENTIFIC AS WELL INDUSTRIAL CHARACTERISATION OF NEW MATERIALS BASED ON POLYMER-CLAY NANOCOMPOSITES

Polymer-clay nanocomposites are interesting class of materials due to possibility of fine tuning of processing as well as utility properties. On the one hand, enough studies have been performed until now concerning principles of clay dispersion in different polymer matrices and effect of clay structure on the final material performance. On the other hand, there are still not many products on the market based on polymers reinforced with nano-scaled layered silicates. One of the main difficulties during development of new materials using clay particles consists in long development times, which reflect the complexity of relevant processing processes (compounding, extrusion, injection moulding). Comparing to conventional composites systems, different physical as well as chemical reactions can occur during the mixing of polymer with organically modified clay and, consequently, long development time to find a proper processing routes (temperature profile, screw geometry, screw speed etc.) is necessary. In this contribution, shear as well as elongational rheometry has been applied for the estimation of physical and chemical interactions during the processing. It is shown that combination of shear and extensional rheology can be used for both research structural characterisation as well for fast industrial quality control of nanoclay-based materials.
THE INFLUENCE OF MILLING AND SANDING ON WOOD SURFACE MORPHOLOGY

The influence of milling and sanding on surface morphology of beech and spruce wood is investigated in the paper. Wood morphology was assessed through roughness and waviness parameters. The experimental results showed that the two wood surface machining techniques studied differed in their impacts on the wood roughness and waviness. Lower roughness was obtained by milling, with the milling parameters (rotation rate, specimen feed speed) not influencing the roughness significantly. The roughness of sanded surfaces was noticeably higher, with the prominent influence of the sanding grit size. In all cases, the roughness was significantly higher perpendicular to grain. The roughness-related results showed that the differences between beech and spruce wood were noticeably reduced by the mechanical treatment. Despite this fact, the impact of wood species was confirmed. The porous character of wood is the cause of the higher roughness of the wood external surface. This implies that wood surface roughness can be smoothed by an appropriate mechanical treatment, but an absolutely smooth surface cannot be acquired.
Development of a Standard Set of Outcome Domains and Proposed Measures for Chronic Obstructive Pulmonary Disease in Primary Care Physical Therapy Practice in the Netherlands: a Modi ﬁ ed RAND/UCLA Appropriateness Method

Background: Standardization of measures in a common set opens the opportunity to learn from differencesintreatmentoutcomeswhichcanbeusedforimprovingthequalityofcare.Furthermore, a standard set can provide the basis for development of quality indicators and is therefore useful for qualityimprovementandpublicreportingpurposes.Theaimofthisstudywasto developastandard set of outcome domains and proposed measures for patients with COPD in Dutch primary care physical therapy practice, including a proposal to stratify patients in subgroups. Material and methods: A consensus-driven modi ﬁ ed RAND-UCLA appropriateness method was conducted with relevant stakeholders (patients, physical therapists, researchers, policy makers and health insurers) in Dutch primary physical therapy care in eight steps: (1) literature search, (2) ﬁ rst online survey, (3) patient interviews, (4) expert meeting, resulting in a concept standard set and methods to identify subgroups' (5) consensus meeting, (6) expert meeting (7) second online survey and (8) ﬁ nal approval of an advisory board resulting of the approved standard set. Results: Five outcome domains were selected for COPD: physical capacity, muscle strength, physical activity, dyspnea and quality of life. A total of 21 measures were rated and discussed. Finally, eight measures were included, of which four mandatory measures: Characteristics of practices and physical therapists, Clinical COPD Questionnaire (CCQ) for quality of life, Global Perceived Effect (GPE) for experience, 6-mins Walk Test (6-MWT) for physical capacity; two conditional measures: Hand-Held Dynamometer (HHD) (with Microfet ™ ) for Quadriceps strength, Medical Research Council Dyspnea (MRC) for monitoring dyspnea; and two exploratory measures:Accelerometryforphysicalactivity,andtheAssessmentofBurdenofCOPDtool(ABC). Toidentifysubgroups,amethoddescribedintheDutchstandardofcarefromtheLungAlliancewas included. Conclusion: This study described the development of a standard set of outcome domains and proposed measures for patients with COPD in primary care physical therapy. Each measure was acceptedforrelevance andfeasibilitybytheinvolvedstakeholders.Thesetiscurrentlyusedindaily practice and tested on validity and reliability in a pilot for the development of quality indicators.