Miracle-dz/UniFAR-FTUs huggingface dataset:
Wine lovers: their interests in tourist experiences

The purpose of this paper is to explore the intrinsic components of wine tourism products that satisfy the consumers and analyze the economic development of wine regions, away from consolidated tourist destinations. ,The objective of the study is fulfilled by reviewing the literature on culture and gastronomy as tourism-driving forces of hinterland development and the needs of wine lovers in their tourism experiences and then using it to design appropriate research tools to collect empirical data through a survey within the context of a single case study. Thus, the specific case of wine origin certification, denomination of origin (DO) in the Catalan regional area of Pla de Bages (Barcelona) is the successful case analyzed, through 210 valid questionnaires. ,Wine tourism has a long history, although it may appear to be quite recent and innovative. Today’s visitors are well travelled and seek new experiences, authentic contexts and particular or exceptional activities. The findings show that the intrinsic components of wine tourism products that satisfy these consumers are critical to develop wine regions, focusing on the design of activities with significant dose of local identity and wine and gastronomic pairing. Definitely, participation, hedonism, significance, knowledge, nostalgia, tasting, novelty and local culture are the basic ingredients of a memorable and satisfying wine tourism experience. ,The present study has several limitations that need to be mentioned. First, this research is a single case study; the Pla de Bages DO serves as the case, focusing on one cultural heritage experience, the large wine vats walking visits. This fact can put the study’s validity in question. Another limitation is that this study is not a longitudinal one, the latter could lead to more accurate findings. It would be interesting to ad in-depth interviews to advance the understanding about how to enhance visits according to the analyzed components. ,Sustainable governance of destinations implies the cooperation of private businesses, the public government and the support of the population of the territory, to develop creative and successful tourist products. Economic, social and cultural networks are necessary to create collaboration and innovation, following its mutual interests. The new governance approach based on networks that combines creative, sensorial and locally specific experiences is essential and offers many business opportunities and entrepreneurial options in hinterland regions, located near consolidated tourist destinations. Destination management organizations and private businesses should take into account the structure of the eight aforementioned components when they design oenological tourism activities. ,The originality of the paper lies in the knowledge of the crucial components of memorable wine tourism experiences to satisfy visitor expectations. They have to include participation, hedonism, significance, knowledge, local culture, novelty, tasting and nostalgia.
Energy-aware noise reduction for wireless acoustic sensor networks

In speech processing applications, e.g., speech recognition, hearing aids (HAs), video conferencing, and human-computer interaction, speech enhancement or noise reduction is an essential front-end task, as the recorded speech signals are inevitably corrupted by interference, including coherent/incoherent noise and reverberation. Traditional noise reduction algorithms are mostly based on spatial filtering techniques using a microphone array. The performance of the noise reduction algorithms scales with the number of microphones that are involved in filtering, but a large-sized microphone array cannot be mounted in many realistic systems, e.g., HAs. In the last few decades, with a great development in micro-electro-mechanical systems, wireless devices are more and more commonly-used in our daily life, like the smartphone, laptop, wireless HA, and ipad. These devices have acoustic sensors equipped and a capability of wireless communication, leading to a wireless acoustic sensor network (WASN). The WASN can be organized in a centralized fashion where all the devices are only allowed to connect with a fusion center (FC), or in a decentralized way where the devices are connected with the close-by counterparts via wireless links. ThisWASN can resolve the disadvantages of the traditional microphone array systems, since thewireless devices can be placed anywhere in the vicinity and one device is able to make use of measurements from other external devices. More importantly, the acoustic scene can be sampled more comprehensively, resulting in a potential improvement in noise reduction performance.
Predicting parenchymal hematoma associated with endovascular thrombectomy for acute occlusion of anterior circulation large vessel: the GuEss-MALiGn scale

Background: Endovascular thrombectomy (EVT) is an emergency treatment for stroke caused by anterior circulation large vessel occlusion (ACLVO). This study aimed to identify the predictors for post-EVT parenchymal hematoma (PH) and to develop a predictive tool using the identified factors. Methods: Using the clinical and imaging data of consecutive patients with acute ACLVO who underwent EVT, we performed a multivariate binary logistic regression analysis to identify predictors for PH. With the predictors proved by the regression, we developed a scale for predicting PH using receiver operating characteristic (ROC) curve analyses. Results: In 233 enrolled patients, the mean age was 72.3 years old, and the male proportion was 46.4%. The rate of PH after EVT was 18.0%: the rate of type 1 PH was 12.9%, and the rate of type 2 PH was 5.2%. The significant predictors for PH were basal ganglia involvement, embolism, male sex, antihyperlipidemic use, lobar infarction, and serum glucose level. We developed the GuEss-MALiGn scale with the six significant predictors. Each of these six items was placed on a Likert scale and scored as a 0 or 1. The ROC curve analysis revealed that the area under the curve was 0.771. The cutoff score for the risk of PH was >3. The sensitivity was 59.5%, and the specificity was 78.0%. Conclusion: We propose the GuEss-MALiGn scale as a tool for predicting PH associated with EVT. Future external validation is needed to determine the reliability of this scale.
The effect of high cholesterol level on recurrence rate of oral ulcer

Introduction: Oral ulcers are one of the most common complaints of the oral mucosa lesion. Ulcer is defined by damage or discontinuity of the epithelium and lamina propria which usually affects the non-keratinized or poorly keratinized surfaces of the oral mucosa. It is a multifactorial condition several predisposing factors have been suggested. Objectives: The aim of this study is to determine the relationship between the increase in cholesterol level and the presence of recurrent oral ulcer. Materials and Methods: A case control study was conducted in oral medicine clinic Kulliyyah of Dentistry International Islamic University Malaysia, Kuantan, Pahang. Convenience sampling was used to select the sample devided into 2 groups patient with recurrent oral ulcer (ROU) (male and female) and control. Patients who fulfilled the criteria were selected. Blood cholesterol and blood pressure of both groups were mesured and recorded. Data analysis was done using independent t-test by, SPSS version 20 for Windows. Results: Cholesterol level was significantly higher in patient with recurrent oral ulcer (6.32 +/- 0.45mmol) compared to control group (4.97 +/- 0.28mmol) (p<0.05). t(46) = 2.75, p = 0.008. It is also found that the control group had statistically significantly lower S.BP (113.77 +/- 2.93 mmHg) compared to the subject group (126.62 +/- 3.61 mmHg), t(46) = 2.75, p = 0.008. Conclusions: This study emphasizes that high cholesterol level is highly associated with ROU.
Effects of Morphine on Serum Reproductive Hormone Levels and the Expression of Genes Involved in Fertility-related Pathways in Male Rats

The effects of morphine on serum reproductive hormone levels and markers involved in fertility-related pathways were evaluated. A total of 30 male Wistar rats were divided into three groups (n = 10) and intraperitoneally administered the following substances for 20 days: two single daily doses of morphine (10 mg/kg; morphine group), saline (healthy saline), and intact group. After confirming the morphine dependence of the experimental groups, all the animals were sacrificed and their total testis tissue was extracted and stored at −80 °C until use. Male reproductive parameters (blood serum of testosterone, luteinizing hormone, and follicle-stimulating hormone) and using Q-PCR and western blot, we evaluated mRNA and protein expression of CREM, TBP, CREB1, HDAC1, and FOS involved in fertility-related pathways were analyzed and compared in the testis samples. The luteinizing hormone and testosterone levels were significantly lower in the morphine-administered group than in the saline and intact groups (P < 0.05). Moreover, the expressions of all five target genes were downregulated in the morphine group (P < 0.05). The protein expression of all five target proteins was downregulated in the morphine group (P < 0.05). We concluded that morphine could decrease the reproductive parameters in male rats.
Post lumbar puncture headache: Case report of a serious adverse event in first-in-human study

A lumbar puncture can be used to measure the concentrations of drugs and/or pharmacodynamic biomarkers during clinical trials of central nervous system drugs. We report a case of a post lumbar puncture headache (PLPH) in a first-in-human study, which was reported as a serious adverse event. A 20-year-old man received 200 mg of the investigational product (IP) for 7 days and underwent a lumbar puncture for cerebrospinal fluid sampling before IP administration (Day 1, pre-dose) and after 7 days and multiple IP administrations (Day 7, 1 hour post-dose). After discharge on Day 8, the subject complained of headache, nausea, vomiting, neck stiffness, and numbness of the extremities. The symptoms occurred when he got up and disappeared after he remained in the supine position for several minutes. Five days later, he visited the neurology clinic of the main hospital. The neurologist recommended hospitalization for further evaluation and symptom management, and the subject was then admitted to the hospital. There were no abnormal findings in vital signs, laboratory results, or brain-computed tomography. His symptoms disappeared during the hospitalization period. It was important to distinguish whether the headache was IP-related or lumbar puncture-related. Therefore, knowledge of clinical characteristics and differential diagnosis of PLPH is paramount. Furthermore, if severe PLPH occurs, a consultation with a neurologist and imaging studies should be considered for a differential diagnosis of PLPH.
Modern technologies for using fish wastes in the production of collagen hydrolysates and functional beverages

The research is devoted to the use of a cod skin hydrolysate as a component of citrus fruit beverages. It is demonstrated that the addition of a hydrolysate increases the content of protein in the beverage, slightly increases the viscosity of the beverage, and does not adversely affect its sensory characteristics. Hydrolysate is produced by enzymatic treatment of cod skin. The processing parameters allowing achieving the desired degree of destruction are determined. Physico-chemical parameters and sensory analyses of the obtained hydrolysate and its amino acid composition were analyzed. The influence of collagen hydrolysate on the physical and chemical composition of beverages, their structural and mechanical characteristics (pH and viscosity) and sensory analyses are estimated.
Abstract 4182: The two novel BTK-inhibitors M2951 and M7583 show in vivo anti-tumor activity in pre-clinical models of B cell lymphoma

Background. Diffuse large B cell lymphoma of the activated B cell like type (ABC DLBCL) is an aggressive lymphoma in which the inhibition of the Bruton’s tyrosine kinase (BTK) has shown biologic and clinical relevance. M7583 and M2951 are two novel highly selective irreversible BTK inhibitors (Fest C et al, 2016). M7583 has shown activity in a mouse model of lupus erythematosus (Bender et al, 2016). Here, we evaluated the anti-tumor activity of M2951 and M7583 in an in vivo ABC DLBCL model. Methods. Xenografts were established by s.c. injecting TMD8 lymphoma cells (100 µL of PBS, 107 cells/mouse) into the left flanks of female NOD-SCID mice (6 weeks of age and around 20g of body weight). Treatments (QD, po) were started with an average tumor volume of 100mm3 on groups of 10 mice each. Results. NOD-SCID mice engrafted with the ABC DLBCL TMD8 were treated with three different concentrations of M7583 (1 mg/Kg; 3 mg/Kg; 10mg/Kg) or M2951 (5 mg/Kg; 15 mg/Kg; 25mg/Kg) or vehicle, as control group. M2951 slowed tumor growth at all doses starting after 10 days of treatment. M7583 at 3 and 10 mg/Kg showed stronger anti-tumor activity than M2951, already evident after 5 days of treatment (P Conclusion. The two novel BTK inhibitors M2951 and M7583 showed promising in vivo anti-tumor activity in an ABC-DLBCL model. These data provide the rational for further investigating these compounds. Citation Format: Eugenio Gaudio, Chiara Tarantelli, Emanuele Zucca, Davide Rossi, Anastasios Stathis, Francesco Bertoni. The two novel BTK-inhibitors M2951 and M7583 show in vivo anti-tumor activity in pre-clinical models of B cell lymphoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4182. doi:10.1158/1538-7445.AM2017-4182
The human metabolome under nutritional challenges in young men and subjects carrying risk alleles for obesity and diabetes mellitus type 2

The thesis investigates the human metabolome, divided into two major topics: 1. ) The dynamics of a multitude of metabolites in response to altered energy substrate availability or demand in plasma, urine, exhaled air, and respiratory condensate samples of healthy young men. 2. ) The impact of two common genetic variants, associated with obesity (FTO) or diabetes type 2 (TCF7L2), on plasma metabolite profiles at baseline and in response to standardized nutritional interventions.
Amino acid composition, protein content and accurate nitrogen-to-protein conversion factor for sheepgrass (Leymus chinensis)

The protein content of plants is commonly estimated by multiplying the total nitrogen content (Kjeldahl; KN) by a nitrogen-to-protein conversion factor of 6.25. This method is based on the incorrect assumption that all nitrogen in the ammonia/ammonium and organic substances in plants is protein nitrogen, usually resulting in overestimation of protein content. We have examined amino acid composition, amino acid nitrogen, total nitrogen (KN), and actual protein content (AP) determined from amino acid residues in 16 accessions of perennial sheepgrass (Leymus chinensis (Trin.) Tzvelev). We determined a new nitrogen-to-protein conversion factor, kP, as the ratio of AP to KN, and applied this factor to estimate the total protein content (TP) as KN × kP. The non-protein nitrogen accounted for 40.5% to 62.4% of the total nitrogen. The average kP value was 3.17 overall, 3.20 in the accessions sampled at the jointing stage, and 3.15 in the accessions sampled at the flowering stage. The TP, calculated as KN × 3.17, was about half that of crude protein contents, calculated as KN × 6.25. Our study suggests that the AP-based kP of 3.17 can be used to more accurately estimate the total protein content in sheepgrass.
Oxford Handbook of Genitourinary Medicine, HIV, and AIDS

Eds Richard Pattman, Michael Snow, Pauline Handy, K Nathan Sankar, Babiker Elawad Oxford University Press, 2006, £24.95, 562 pages ISBN 0 19 852077 8 Rating: ★★★★★/5 Sex sells anything, so this guide to the mysteries of the “special” clinic should do well. The guide takes a disease based view of the conditions seen in clinic and will be useful to anyone working in the specialty, from student to consultant. The book will also be useful for the growing number of nurses working autonomously within clinics, and to that species unique to genitourinary (GU) clinics—health advisers. Fifty five …
Development and Application of Dynamic Timing Optimization Platform for Big Data Intelligent Traffic Signals

As the number of car ownership increases, road traffic flow continues to increase. At the same time, traffic pressure at intersections is increasing as well. At present, most of the traffic lights in China are fixed cycle control. This timing control algorithm obviously cannot make timely adjustments according to changes in traffic flow. In this case, a large number of transportation resources would be wasted. It is very necessary to establish a dynamic timing system for Big data intelligent traffic signals. In this research, the video recognition method was used to acquire the number of vehicles at the intersection in real time, and the obtained data was processed by the optimization algorithm to make a reasonable dynamic timing of the traffic signals. The test results show that after using the big data intelligent traffic signal dynamic timing optimization control platform, in the experimental area, the overall total delay time was reduced by 23%, and the travel time was reduced by 15%. During the off-peak period, the overall total delay time in the experimental region was reduced by 17% and travel time was reduced by 10%. The big data intelligent traffic signal dynamic timing optimization platform would improve the operational efficiency and traffic supply capacity of the existing transportation infrastructure, and could provide real convenience for citizens.
Violence against women: a study on nature, prevalence and extent

Background: To study the nature, prevalence and extent of domestic violence against women in the study area. Methods: The cross-sectional study was carried out in the urban and rural area of Surendranagar district of Gujarat. Total 600 ever married women of 15-49 years of age were selected for the study purpose. The self-administered questionnaire was used to gather all the information. Steps were taken up to maintain confidentiality. Results: Out of total 600 women, 231 (38.5%) were victims of domestic violence in one form or the other. The analysis based on each form of violence discloses that about 83% were victims of psychological violence, about 54% of the victims had experienced physical violence, about 32% were victims of economical violence and about 24% were victims of sexual violence. Conclusions: Husband was the frequent instigator of domestic violence. Psychological violence is the commonest form of violence experienced by the victims.
A Fuzzy Logic Model for Power Transformer Faults’ Severity Determination Based on Gas Level, Gas Rate, and Dissolved Gas Analysis Interpretation

In determining the severity of power transformer faults, several approaches have been previously proposed; however, most published studies do not accommodate gas level, gas rate, and Dissolved Gas Analysis (DGA) interpretation in a single approach. To increase the reliability of the faults’ severity assessment of power transformers, a novel approach in the form of fuzzy logic has been proposed as a new solution to determine faults’ severity using the combination of gas level, gas rate, and DGA interpretation from the Duval Pentagon Method (DPM). A four-level typical concentration and rate were established based on the local population. To simplify the assessment of hundreds of power transformer data, a Support Vector Machine (SVM)-based DPM with high agreements to the graphical DPM has been developed. The proposed approach has been implemented to 448 power transformers and further implementation was done to evaluate faults’ severity of power transformers from historical DGA data. This new approach yields in high agreement with the previous methods, but with better sensitivity due to the incorporation of gas level, gas rate, and DGA interpretation results in one approach.
Impact of Remittances on Financial Development: Revisiting the Evidence for ECOWAS Countries

This study examines the impact of remittances on financial development in selected West African countries over the period from 1980 to 2017. Contrary to previous panel studies which relied on standard panel estimators, it uses an estimation method which controls both parameter heterogeneity and cross-section dependence among countries. Remittance inflows were found to reduce domestic credit to private sector whereas they contribute to increasing money supply in the long run. Country-level results reveal, however, considerable heterogeneity across countries.
Characterization of Organic Acid Producing Aspergillus tubingensis FMS1 and its Role in Metals Leaching from Soil

Abstract Metallotolerant fungi are known for their ability to adapt to high concentrations of heavy metals by producing extracellular metabolites. We isolated an acid-producing filamentous fungus, designated as strain FMS1, from metal-polluted soil and identified as Aspergillus tubingensis by sequence analysis of internal transcribed spacer regions. Physicochemical conditions for growth as well as maximum tolerance to various metals was determined. The carbon source was optimized for maximum yield of various organic acids that were finally characterized as well as quantified through high-performance liquid chromatography (HPLC) analysis. Moreover, these organic acids were applied for leaching of heavy metals from metal contaminated soil. Three organic acids were produced in high concentration, gluconic acid (265 mM), oxalic acid (24 mM), and fumaric acid (0.34 mM) in the presence of sucrose, hence considered it as an ideal carbon source. The highest leaching efficiency with organic acids from strain FMS1 was observed for cadmium (58%), cobalt (53%), and nickel (52%) after 28 days soil incubation. Additionally, these organic acids were found to leach out heavy metals from soil as well. It is concluded that the above-mentioned results could be of great interest for bioleaching and may be applied for efficient and cost-effective bioremediation of metal-polluted soil.
Ionogel-based sodium ion micro-batteries with a 3D Na-ion diffusion mechanism enable ultrahigh rate capability

The rapid development of microelectronics and microsystems has stimulated the continuous evolution of high-performance and cost-effective micro-batteries. Despite their competitiveness with huge application potential, sodium ion micro-batteries (NIMBs) are still underdeveloped. Herein, we demonstrate one prototype of a quasi-solid-state planar ionogel-based NIMB constructed by separator-free interdigital microelectrodes of sodium titanate anode and sodium vanadate phosphate cathode, both of which are embedded into a three-dimensional interconnected graphene scaffold. Meanwhile, a novel NaBF4-based ionogel electrolyte with robust ionic conductivity of 8.1 mS cm−1 was used. Benefiting from the synergetic merits from the planar architecture, dominant pseudocapacitance contribution, and 3D multi-directional Na-ion diffusion mechanism, the as-assembled NIMBs exhibit high volumetric capacity of 30.7 mA h cm−3 at 1C, and high rate performance with 15.7 mA h cm−3 at 30C at room temperature and 13.5 mA h cm−3 at 100C at a high temperature of 100 °C. Moreover, the quasi-solid-state NIMBs present outstanding flexibility, tunable voltage and capacity output, and remarkable areal energy density of 145 μW h cm−2 (55.6 mW h cm−3). Therefore, this work will provide numerous chances to construct planar NIMBs for microsystems.