Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of an Assessment of Functioning Scale for Prison Environments

This paper reports the development of a global assessment of functioning (GAF), modified from the DSM Axis V GAF for the prison environment. Focus groups, which were conducted with 36 correctional officers and clinicians in two prisons, provided descriptions of behavior in prison settings to re-align the GAF scale. Face validity was established. It was found that Habitation/Behavior, Social, and Symptoms emerged as important domains of functioning in prison. Gender differences were noted with regard to cleanliness, relationships and coping strategies. The cut-off score was identified at a score where offenders were unable to participate in a disciplinary process due to their mental illness. The structure of prison alters human functioning, requiring different assessment language and ratings to measure perceived behavioral norms and/or expectations. Front-line staff need the ability to observe and communicate behavioral changes quickly and accurately in a prison environment without undue burden upon their workload. This assessment was modified by front-line staff specifically for the prison environment to document quick and frequent assessments of observed changes over time in the offender population.
A novel marginal periosteal pedicle graft as an autogenous guided tissue membrane for the treatment of intrabony periodontal defects.

OBJECTIVE The aim of the present study was to clinically examine the effects of a novel marginal periosteal pedicle graft (MPP) as a guided tissue membrane for treating proximal intrabony defects in comparison to a an open flap debridement. MATERIAL AND METHODS Fifteen patients with severe chronic periodontitis and no systemic diseases participated in this prospective, controlled clinical trial. Each subject contributed matched pairs of interproximal two- or three-walled intrabony defects. Baseline clinical examination included plaque index (PlI), gingival index (GI), bleeding on probing (BOP), probing depth (PD) and clinical attachment level (CAL) of selected sites and were performed two weeks following completion of cause-related therapy. Radiographic measurements were also recorded to ascertain the radiographic depth of the defect. Each pair of periodontal defects were randomly assigned into the experimental group G1, marginal periosteal pedicle graft (MPP) guided tissue membrane or the control open flap debridement group, G2. In the MMP, partial thickness flaps were elevated at the vestibular surface of the tooth adjacent to the interproximal defect to harvest a 4 mm marginal pedicle periosteal graft. Exposed root surfaces were root planed and the remaining bony walls of the selected defect were degranulated prior to the periosteal pedicle barrier membrane being rotated to cover the intrabony defect. Sites representing the control group were treated with only open flap debridement. Clinical and radiographic parameters were recorded at 3, 6 and 9 months after surgery for treatment outcome evaluation. RESULTS Baseline data showed no differences in any of the investigated parameters, suggesting parameters were balanced between the two groups. Both experimental and control groups showed significant improvements in all of the soft and hard tissue parameters when compared to baseline (p < 0.001). At nine months, the experimental MPP group showed significant improvement in PD reduction, CAL gain and intrabony defect reduction when compared to the control (p < 0.01). In the MPP group, the mean reduction in PD was 3.8 mm, mean CAL gain was 3.4 mm and mean reduction in intrabony defect was 2.2 mm. In sites treated with open flap DEBRIDEMENT, the mean PD reduction was 2.5 mm, CAL gain was 2.0 mm and mean reduction in intrabony defect was 0.6 mm. CONCLUSION Within the limits of this study, it can be concluded that the placement of a marginal periosteal pedicle graft as a barrier membrane significantly improved clinical and radiographic parameters of deep intrabony defects and proved superior to OPEN FLAP DEBRIDEMENT alone.
A static checker for safe pattern matching in Haskell

A Haskell program may fail at runtime with a pattern-match error if the program has any incomplete (non-exhaustive) patterns in definitions or case alternatives. This paper describes a static checker that allows non-exhaustive patterns to exist, yet ensures that a pattern-match error does not occur. It describes a constraint language that can be used to reason about pattern matches, along with mechanisms to propagate these constraints between program components.
Data locality optimization of shared memory programs on NUMA architectures using an integrated tool environment

Due to their excellent price-performance ratio, clusters built from commodity nodes have become broadly adopted and increasingly popular as platforms for parallel processing. Among them, the clusters of standard PCs interconnected with high-speed system area networks (SANs) are especially attractive and have been widely established. At the same time, the developments in interconnection technologies also formed the basis for the rise of Non-Uniform Memory Access (NUMA) architectures, i.e. systems with physically distributed memories, but with a global address space allowing an efficient but non-uniform access to any memory location in the system. These kinds of systems, especially when offered as non cache coherent NUMA for loosely coupled commodity architectures, can easily be implemented in a straightforward manner without major hardware efforts. They form a favorable architectural tradeoff by combining the scalability and cost–effectiveness of standard clusters with a shared memory support close to symmetric multiprocessors. The non-uniform memory access characteristic, however, introduces a distinction between local and remote memory causing different memory access latencies. In systems with such characteristics, a remote memory access can take up to an order of magnitude longer than a local one. This leads to the fact that many shared memory applications initially do not achieve a good parallel speedup when running on NUMA-like architectures due to excessive remote memory accesses. This thesis targets such inefficiency problems of NUMA-based shared memory programs. For this purpose, a comprehensive and integrated tool environment has been built which aims at improving the data locality of running applications, by combining single frameworks enabling both program tuning and runtime manipulation. This environment comprises a low-level data acquisition system, a distributed tool middleware, and a set of performance tools. Based on the hardware monitoring facility, which is capable of observing all memory transactions performed on the interconnection fabric, the data acquisition system provides information about an application’s memory access behavior as well as information about e.g. synchronization primitives and address mapping necessary for data placement. This information is then aggregated across the distributed system and made accessible to the tools through an established on-line monitoring interface specification serving as middleware. Tools further process the acquired performance data and use it to steer the execution of programs with a result of an optimization for the runtime data layout. Currently, two such tools have been implemented: a Data Layout Visualizer (DLV) and an Adaptive Runtime System (ARS). DLV is used to present the monitoring data in an easy-
SELECTION, PRIORITIZATION, AND CHARACTERISTICS OF KEPLER TARGET STARS

The Kepler Mission began its 3.5 year photometric monitoring campaign in 2009 May on a select group of approximately 150,000 stars. The stars were chosen from the ∼ half million in the field of view that are brighter than 16th magnitude. The selection criteria are quantitative metrics designed to optimize the scientific yield of the mission with regard to the detection of Earth-size planets in the habitable zone. This yields more than 90,000 G-type stars on or close to the main sequence, >20, 000 of which are brighter than 14th magnitude. At the temperature extremes, the sample includes approximately 3000 M-type dwarfs and a small sample of O- and B-type MS stars (<200). The small numbers of giants are included in the sample: ∼5000 stars with surface gravities log(g) < 3.5. We present a brief summary of the selection process and the stellar populations it yields in terms of surface gravity, effective temperature, and apparent magnitude. In addition to the primary, statistically derived target set, several ancillary target lists were manually generated to enhance the science of the mission, examples being: known eclipsing binaries, open cluster members, and high proper motion stars.
Throughput measurements for access-point installation optimization in IEEE802.11n wireless networks

Currently, high-speed IEEE802.11n interfaces using MIMO have become common in access points (APs) and personal computers (PCs) for wireless local-area networks (WLANs). This trend leads to further expand the application areas for WLANs. In this paper, we present throughput measurement results of IEEE802.11n devices with various placement orientations in indoor environments. They show that measured throughputs are strongly affected by the roll and yaw angles at the installation of AP due to the multiple antennas in MIMO, which should be considered in optimizing the installation of APs in indoor fields.
Acetabular Labral Tears Rarely Occur in the Absence of Bony Abnormalities

We evaluated the percentage of patients with acetabular labral tears who have a structural hip abnormality detectable by conventional radiography. Records from our institution from 1996 through 2002 were reviewed to identify all patients with labral tears. Patients were excluded who had classic hip dysplasia, advanced osteoarthritis, or a history of pelvic or femoral osteotomy. The hip radiographs were evaluated for abnormalities of Tönnis angle, center-edge angle of Wiberg, acetabular version, femoral neck-shaft angle, congruency between the femoral head and acetabulum, anterior femoral head-neck offset, and presence of femoral head osteophytes. Twenty-seven of the 31 patients (87%) had at least one abnormal finding and 35% had more than one abnormality. Ten patients had a retroverted acetabulum, 16 had coxa valga, 11 had an abnormal femoral head-neck offset, and 14 had osteophytes on the femoral head. Four of 31 patients (13%) had no identifiable structural abnormalities. To our knowledge, this is the first study to document that the majority of patients with labral tears have a structural hip abnormality detectable with conventional radiographs. Familiarity with these structural abnormalities is important for early detection and accurate diagnosis, and may impact optimal treatment planning and prognosis.
A Generic Fault Countermeasure Providing Data and Program Flow Integrity

So far many software countermeasures against fault attacks have been proposed. However, most of them are tailored to a specific cryptographic algorithm or focus on securing the processed data only. In this work we present a generic and elegant approach by using a highly fault secure algebraic structure. This structure is compatible to finite fields and rings and preserves its error detection property throughout addition and multiplication. Additionally, we introduce a method to generate a fingerprint of the instruction sequence. Thus, it is possible to check the result for data corruption as well as for modifications in the program flow. This is even possible if the order of the instructions is randomized. Furthermore, the properties of the countermeasure allow the deployment of error detection as well as error diffusion. We point out that the overhead for the calculations and for the error checking within this structure is reasonable and that the transformations are efficient. In addition we discuss how our approach increases the security in various kinds of fault scenarios.
The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause

The tissue-selective estrogen complex (TSEC) pairs conjugated estrogens (CE) with a selective estrogen receptor modulator (SERM), bazedoxifene acetate (BZA). A 2-year treatment with the TSEC improved vasomotor symptoms, quality of life, and vaginal atrophy in healthy postmenopausal women. In addition, the TSEC prevented vertebral and hip bone loss without increasing mammographic density, breast tenderness, the risk of myocardial infarction, stroke, or venous thromboembolism. Finally, the BZA 20 mg/CE 0.45 mg dose did not increase the risk of endometrial hyperplasia. Based on these findings, the TSEC can be considered as a first-line treatment for symptomatic postmenopausal women.
The functional state of follicular dendritic cells in severe combined immunodeficient (SCID) mice: Role of the lymphocytes

In the present study, we have investigated the capacity of follicular dendritic cells (FDC) to trap immune complexes (IC) in the splenic white pulp of severe combined immunodeficient (SCID) mice and the influence of lymphocyte transfer on FDC function. FDC are absent in the splenic white pulp of naive SCID mice as revealed by in vitro IC trapping assay. One week after transfer of syngeneic lymphocytes, functional FDC with complement receptors appeared in the primary follicles coincident with B cell segregation, and IC were trapped on those FDC in a complement‐dependent manner. Next, we immunized the reconstituted SCID mouse to see whether another type of FDC could be induced in the secondary follicle. Antigenic stimulation induced FDC with an additional capacity to capture IC via FcR γ II. As seen in immunocompetent mice, this type of FDC was located only in the light zone of the secondary follicle. The newly generated FDC did not carry H‐2 antigen of transferred lymphocytes from F1 mice. In SCID mice, in which normally no functional FDC are detectable, the microenvironments of the splenic white pulp have a capacity to develop and differentiate normally after transfer of lymphocytes. Apparently, the generation of functional IC‐trapping FDC causes the induction of complement receptor(s) and Fc receptor on meshwork cells, which requires the presence of the lymphocytes.
Properties of Novel International Drug-Resistant Pneumococcal Clones Identified in Day-Care Centers of Lisbon, Portugal

ABSTRACT In this study, 61 drug-resistant Streptococcus pneumoniae strains were characterized by multilocus sequence typing (MLST). These strains were representatives of 26 major clones (defined using pulsed-field gel electrophoresis) accounting for 93% of the 1,285 drug-resistant Streptococcus pneumoniae isolates recovered from the nasopharynges of healthy children attending day-care centers in Lisbon during 2001 to 2003. Using MLST, 13 of the 26 clones were found to be identical or closely related to 11 Pneumococcal Molecular Epidemiology Network (PMEN) clones, 4 clones were found to be unique as there were no identical or highly related allelic profiles deposited in the MLST database, and the remaining 9 clones had sequence types that matched or differed at a single or double locus from allelic profiles available in the MLST database. These nine clones were of serotypes 33F, 10A, 19A, 19F, 6A, 20, 24F, and 3, one was nontypeable, and, by MLST, they were found to be identical or highly related to isolates from disease origin that were dispersed internationally. Since the majority of these clones had serotypes that are not included in the 7-valent conjugate pneumococcal vaccine, monitoring of these clones is important for surveying their possible spread in the future. We propose the inclusion of these novel international clones in the PMEN.
Heat shock protein 27: its potential role in vascular disease

Heat shock proteins are molecular chaperones that have an ability to protect proteins from damage induced by environmental factors such as free radicals, heat, ischaemia and toxins, allowing denatured proteins to adopt their native configuration. Heat shock protein‐27 (Hsp27) is a member of the small Hsp (sHsp) family of proteins, and has a molecular weight of approximately 27 KDa. In addition to its role as a chaperone, it has also been reported to have many additional functions. These include effects on the apoptotic pathway, cell movement and embryogenesis. In this review, we have focused on its possible role in vascular disease.
Diverse profiles of N-acyl-homoserine lactone molecules found in cnidarians.

Many marine habitats, such as the surface and tissues of marine invertebrates, including corals, harbour diverse populations of microorganisms, which are thought to play a role in the health of their hosts and influence mutualistic and competitive interactions. Investigating the presence and stability of quorum sensing (QS) in these ecosystems may shed light on the roles and control of these bacterial communities. Samples of 13 cnidarian species were screened for the presence and diversity of N-acyl-homoserine lactones (AHLs; a prevalent type of QS molecule) using thin-layer chromatography and an Agrobacterium tumefaciens NTL4 biosensor. Ten of 13 were found to harbour species-specific, conserved AHL profiles. AHLs were confirmed in Anemonia viridis using liquid chromatography tandem mass spectrometry. To assess temporal role and stability, AHLs were investigated in A. viridis from intertidal pools over 16 h. Patterns of AHLs showed conserved profiles except for two mid-chain length AHLs, which increased significantly over the day, peaking at 20:00, but had no correlation with pool chemistry. Denaturing gel electrophoresis of RT-PCR-amplified bacterial 16S rRNA showed the presence of an active bacterial community that changed in composition alongside AHL profiles and contained a number of bands that affiliate with known AHL-producing bacteria. Investigations into the quorum sensing-controlled, species-specific roles of these bacterial communities and how these regulatory circuits are influenced by the coral host and members of the bacterial community are imperative to expand our knowledge of these interactions with respect to the maintenance of coral health.
[Disseminated encephalic cryptococcosis as a form of presentation of idiopathic T-CD4 lymphocytopenia].

INTRODUCTION The term idiopathic T-CD4 lymphocytopenia is used to describe a new syndrome, defined as reduced T-CD4 lymphocytes in persons with no evidence of HIV infection or other causes which would explain the immunosuppression (secondary to neoplasties, immunosuppressive treatment, hereditary immunodeficiencies, infections, etc.). The reduced number of T-CD4 lymphocytes leads to deterioration in cellular immunity and therefore this leads to a predisposition to develop tumors and opportunist infections in patients with such defects. CLINICAL CASE We describe a case of depletion of T-CD4 lymphocytes, associated with disseminated encephalic cryptococcosis (multiple cortical, capsulo-ganglionar, thalamic and cerebellar cryptococcomas) in a patient with no evidence of HIV infection. The case we present fulfilled diagnostic criteria for idiopathic T-CD4 lymphocytopenia, a clinical condition seldom described in this country. We discuss the pathogenic mechanisms of cryptococcosis, the different varieties of Cryptococcus neoformans and their different roles as the cause of opportunist infections in humans. CONCLUSIONS In view of the neurotrophism of this fungus, the neurological signs and symptoms should make one suspect the presence of Cryptococcus neoformans infection in non-HIV carriers with cellular immunity defects such as those present in idiopathic T-CD4 lymphocytopenia.
The correlation between epidermal growth factor levels in saliva and the severity of oral mucositis during oropharyngeal radiation therapy

Epidermal growth factor (EGF) is present in biologic fluids, including saliva, and plays a role in maintenance of the epithelial barrier and in healing of damaged mucosa. The purpose of this study was to assess the relation between salivary EGF and the severity of oral mucositis in patients with carcinoma of the head and neck during radiation therapy.
Extracellular ATP differentially affects epileptiform activity via purinergic P2X7 and adenosine A1 receptors in naive and chronic epileptic rats

Purpose: Adenosine is considered an endogenous anticonvulsant. However, much less is known about the putative effects of its precursor, ATP, on epilepsy. Therefore, we tested whether ATP and its receptors are able to modulate epileptiform activity in the medial entorhinal cortex of the rat.
Ventriculo-Arterial Decoupling in Aortic Stenosis: When the Ventricle and the Arteries Do Not Dance on the Same Tempo

Institut Universitaire de Cardiologie et de Pneumologie de Québec / Québec Heart & Lung Institute, Department of Medicine, Laval University, Québec, Canada FACC Fellow of the American College of Cardiology FAHA Fellow of the American Heart Association FESC Fellow of the European Society of Cardiology FASE Fellow of the American Society of Echocardiography Rev ARgent CARdiol 2016;84:305-308. http://dx.doi. org/10.7775/rac.es. v84.i4. 9020 VÉASE CONTENIDO RELACIONADO: Rev Argent Cardiol 2016;84:315-321. http://dx.doi. org/10.7775/rac.es. v84.i4. 8714
Late Quaternary fi re regimes of Australasia

We have compiled 223 sedimentary charcoal records from Australasia in order to examine the temporal and spatial variability of fire regimes during the Late Quaternary. While some of these records cover more than a full glacial cycle, here we focus on the last 70,000 years when the number of individual records in the compilation allows more robust conclusions. On orbital time scales, fire in Australasia predominantly reflects climate, with colder periods characterized by less and warmer intervals by more biomass burning. The composite record for the region also shows considerable millennial-scale variability during the last glacial interval (73.5e14.7 ka). Within the limits of the dating uncertainties of individual records, the variability shown by the composite charcoal record is more similar to the form, number and timing of DansgaardeOeschger cycles as observed in Greenland ice cores than to the variability expressed in the Antarctic ice-core record. The composite charcoal record suggests increased biomass burning in the Australasian region during Greenland Interstadials and reduced burning during Greenland Stadials. Millennial-scale variability is characteristic of the composite record of the subtropical high pressure belt during the past 21 ka, but the tropics show a somewhat simpler pattern of variability with major peaks in biomass burning around 15 ka and 8 ka. There is no distinct change in fire regime corresponding to the arrival of humans in Australia at 50 10 ka and no correlation between archaeological evidence of increased human activity during the past 40 ka and the history of biomass burning. However, changes in biomass burning in the last 200 years may have been exacerbated or influenced by humans. 2010 Elsevier Ltd. All rights reserved.