Miracle-dz/UniFAR-FTUs huggingface dataset:
Development, Testing, and Findings of a Pediatric-Focused Trigger Tool to Identify Medication-Related Harm in US Children's Hospitals

OBJECTIVES. The purposes of this study were to develop a pediatric-focused tool for adverse drug event detection and describe the incidence and characteristics of adverse drug events in children's hospitals identified by this tool. METHODS. A pediatric-specific trigger tool for adverse drug event detection was developed and tested. Eighty patients from each site were randomly selected for retrospective chart review. All adverse drug events identified using the trigger tool were evaluated for severity, preventability, ability to mitigate, ability to identify the event earlier, and presence of associated occurrence report. Each trigger and the entire tool were evaluated for positive predictive value. RESULTS. Review of 960 randomly selected charts from 12 children's hospitals revealed 2388 triggers (2.49 per patient) and 107 unique adverse drug events. Mean adverse drug event rates were 11.1 per 100 patients, 15.7 per 1000 patient-days, and 1.23 per 1000 medication doses. The positive predictive value of the trigger tool was 3.7%. Twenty-two percent of all adverse drug events were deemed preventable, 17.8% could have been identified earlier, and 16.8% could have been mitigated more effectively. Ninety-seven percent of the identified adverse drug events resulted in mild, temporary harm. Only 3.7% of adverse drug events were identified in existing hospital-based occurrence reports. The most common adverse drug events identified were pruritis and nausea, the most common medication classes causing adverse drug events were opioid analgesics and antibiotics, and the most common stages of the medication management process associated with preventable adverse drug events were monitoring and prescribing/ordering. CONCLUSIONS. Adverse drug event rates in hospitalized children are substantially higher than previously described. Most adverse drug events resulted in temporary harm, and 22% were classified as preventable. Only 3.7% were identified by using traditional voluntary reporting methods. Our pediatric-focused trigger tool is effective at identifying adverse drug events in inpatient pediatric populations.
Mutations in CHMP2B are not a cause of frontotemporal lobar degeneration in Finnish patients

Background: Frontotemporal lobar degeneration (FTLD) is a genetically complex disorder. The majority of mutations linked to FTLD families are found in the microtubule‐associated protein tau (MAPT) and progranulin (PGRN) genes. Mutations in the chromatin‐modifying protein 2B gene (CHMP2B) have been identified in a few families. However, CHMP2B has been showed to be a rare cause of FTLD. Our aim was to determine the frequency of CHMP2B mutations in a clinical series of patients with FTLD in Northern Finland.
A OTIMIZAÇÃO DE PROCESSOS EM PEQUENAS E MÉDIAS EMPRESAS UTILIZANDO SISTEMAS DE ERP

O presente artigo tem como objetivo apresentar os beneficios que as pequenas e medias empresas podem obter ao aperfeicoarem seus processos com a utilizacao de sistemas de ERP, apresentando suas vantagens e desvantagens e os desafios enfrentados pelos seus funcionarios e gestores durante o todo o processo de implantacao. Sao mostrados tambem dados estatisticos a respeito do atual cenario de utilizacao dos sistemas no Brasil, tao como as principais caracteristicas, aplicacoes e funcionalidades do ERP.
A framework for the visualisation and control of ubiquitous devices, services and digital content

The General Organization for Technical Education and Vocational Training, Riyadh, Saudi Arabia, has developed a special feeding program for the students at its institutions. The effects of this program on the nutritional and health status of these students have not been evaluated yet, and since no published dietary research has been performed on Technical and Vocational young adult male students, the present work was undertaken to investigate the nutritional status of this community in Riyadh, Kingdom of Saudi Arabia. After a pilot survey, it was decided to use a selfcompleted questionnaire combined with personal interview to investigate the nutritional status of 690 students randomly selected from the study population. Dietary data was collected by two methods: usual weekly intakes "diet history" and actual daily intakes "diet diary". The nutrient intakes were calculated using the unilever Dietary Analysis Program (UNIDAP). The statistical Package for the social Science (SPSS/PC+) was employed to analyse the data; statistical significance of relationships between certain sets of data was determined by chi-square analysis. Some general factors affecting the nutritional status of these students were identified, their nutritional habits and attitudes were investigated, and the average daily intakes of energy, the macronutrients, and selected micronutrients were calculated. The main results of this study shows that the majority of the study population are adolescent, moderately active individuals, and have lower than the standard range of the Body Mass Index; anaemia is the most stated health problem; meal-skipping and eating between meals are common habits amongst the students. Regarding nutrient intake, there was an energy, polyunsaturated fat, and vitamin C deficiency; adequate intake of saturated fat, dietary fibre, retinol, and zinc; more than adequate intake of protein, total fat, cholesterol, thiamin, riboflavin, calcium, and iron. Recommendations are given which aim to improve the nutrition of technical and vocational students.
Effect of positive end-expiratory pressure on pulmonary shunt and dynamic compliance during abdominal surgery.

BACKGROUND General anaesthesia decreases pulmonary compliance and increases pulmonary shunt due to the development of atelectasis. The presence of capnoperitoneum during laparoscopic surgery may further decrease functional residual capacity, promoting an increased amount of atelectasis compared with laparotomy. The aim of this study was to evaluate the effects of different levels of positive end-expiratory pressure (PEEP) in both types of surgery and to investigate whether higher levels of PEEP should be used during laparoscopic surgery. METHODS This prospective observational study included 52 patients undergoing either laparotomy or laparoscopic surgery. Three levels of PEEP were applied in random order: (1) zero (ZEEP), (2) 5 cmH2O and (3) 10 cmH2O. Pulmonary shunt and ventilation/perfusion mismatch were assessed by the automatic lung parameter estimator system. RESULTS Pulmonary shunt was similar in both groups. However, in laparotomy, a PEEP of 5 cmH2O significantly decreased shunt when compared with ZEEP (12 vs 6%; P=0.001), with additional PEEP having no further effect. In laparoscopic surgery, a significant reduction in shunt (13 vs 6%; P=0.001) was obtained only at a PEEP of 10 cmH2O. Although laparoscopic surgery was associated with a lower pulmonary compliance, increasing levels of PEEP were able to ameliorate it in both groups. CONCLUSION Both surgeries have similar negative effects on pulmonary shunt, while the presence of capnoperitoneum reduced only the pulmonary compliance. It appears that a more aggressive PEEP level is required to reduce shunt and to maximize compliance in case of laparoscopic surgery.
Nuclear Export of the Human Cytomegalovirus Tegument Protein pp65 Requires Cyclin-Dependent Kinase Activity and the Crm1 Exporter

ABSTRACT We have previously shown that treatment of human cytomegalovirus-infected cells with the cyclin-dependent kinase (cdk) inhibitor roscovitine has significant effects on several stages of the virus life cycle depending on the time of addition (V. Sanchez, A. K. McElroy, J. Yen, S. Tamrakar, C. L. Clark, R. A. Schwartz, and D. H. Spector, J. Virol. 78:11219-11232, 2004; V. Sanchez and D. Spector, J. Virol. 80:5886-5896, 2006). In this report, we add to these findings by demonstrating alterations in the phosphorylation and localization of pp65 (UL83) in cells treated with roscovitine. We observed that inhibition of cdk activity causes the retention of pp65 within the nucleus at late times postinfection. At the same time, we observed a change in the phosphorylation pattern of the protein. Interestingly, mutation of potential cdk phosphorylation sites did not affect the ability of pp65 to localize to the nucleus or to relocalize to the cytoplasm late in infection. However, we found that the cytoplasmic accumulation of pp65 late in infection was sensitive to the Crm1 inhibitor leptomycin B.
Inferring network paths from point observations

The use of geographically referenced point data, such as that obtained from global positioning systems (GPS), is rapidly increasing. However, due to error and uncertainty inherent in most geographic datasets, the ability to accurately associate these point locations with other layers of geographic data is still a challenge. One difficulty in particular is how to associate spatially and temporally referenced point-based observations of a network activity with a network topology such that a continuous network path can be best inferred. In this article, an optimization method for inferring a network path from a temporal sequence of point observations of location is presented. An application to GPS data is provided to highlight various characteristics of the proposed modeling approach relative to several other available techniques.
Smartphone Forensic Analysis: A Case Study for Obtaining Root Access of an Android Samsung S3 Device and Analyse the Image without an Expensive Commercial Tool

Smartphone is a very useful and compact device that fits in person’s pocket, but at the same time it can be used as a tool for criminal activities. In this day and age, people increasingly rely on smart phones rather than desktop computers or laptops to exchange messages, share videos and audio messages. A smartphone is almost equivalent in its application to a PC, hence there are security risks associated with its use such as carrying out a digital crime or becoming a victim of one. Criminals can use smartphones for a number of activities. Namely, committing a fraud over e-mail, harassment via text messages, drug trafficking, child pornography, communications related to narcotics, etc. It is a great challenge for forensic experts to extract data from a smartphone for forensic purposes that can be used as evidence in the court of law. In this case study, I show how to obtain the root access of Samsung S3 phone, how to create DD image and then how to examine DD image via commercial tool like UFED physical analyzer trial version which doesn’t support Android devices? I will extract the messages for Viber on trial version of UFED Physical analyzer.
Data analysis in Weitzenbock space

The statistical analysis of data lying on a differentiable, locally Euclidean, manifold introduces a variety of challenges because the analogous measures to standard Euclidean statistics are local, that is only defined within a neighbourhood of each datapoint. This is because the curvature of the space means that the connection of Riemannian geometry is path dependent. In this paper we transfer the problem to Weitzenbock space, which has torsion, but not curvature, meaning that parallel transport is path independent, and rather than considering geodesics, it is natural to consider autoparallels, which are ‘straight’ in the sense that they follow the local basis vectors. We demonstrate how to generate these autoparallels in a data-driven fashion, and show that the resulting representation of the data is a useful space in which to perform further analysis.
A Phase and Amplitude Tunable Quadrature $LC$ Oscillator: Analysis and Design

This paper presents a new analytical approach to extract closed form equations for phase and amplitude imbalances raised from mismatches between two LC-tanks in quadrature oscillators. For more generality, we considered different coupling factors for the two coupled oscillators. This makes our analysis so general that we could design a phase and amplitude tunable quadrature oscillator accordingly. We show that choosing appropriate inversely proportional coupling factors makes it possible to have exactly zero phase and amplitude errors. Choosing so does not have any impacts on phase noise; indeed, the trade-off between phase noise and phase error in coupled quadrature oscillators has been broken here. We show that using differential stages for tuning tail currents of oscillating stages can somehow implement the inversely proportional coupling factors. Tuning the phase and amplitude errors, the frequency does not change and power consumption remains constant too; these are the advantages of the proposed circuit. The theoretical results and proposed quadrature oscillator are evaluated and confirmed through simulations using TSMC 0.18 model technology on a 5-GHz quadrature oscillator with current consumption of 4.2 mA at 1.8 V supply voltage.
Eine Reise in die Unendlichkeit und über die Unendlichkeit hinaus

Reisen in die Unendlichkeit unternehmen wir auf der Erde taglich: Im Paradoxon des Zenon benotigt Achilles unendlich viele Schritte, bis er die vor ihm laufende langsamere Schildkrote einholt. Und wir unternehmen sogar Reisen weit uber die Unendlichkeit hinaus, wenn wir bei Bewegungsvorgangen Korper nicht nur einholen, sondern uberholen. Denn wie viele Schritte hat Achilles zuruckgelegt, nachdem er die Schildkrote hinter sich gelassen hat? Konzeptuell noch interessanter werden solche Fragestellungen, wenn sich Achilles beschleunigt bewegt und unendlich weit entfernte Objekte uberholt. Mit dem folgenden Beitrag werden zwei Ziele verfolgt: Einerseits wird das Paradoxon des Zenon in einen speziell-relativistischen Kontext gestellt und analysiert. Zum zweiten aber ist klar, dass die konzeptuell-mathematische Beschreibung mit Hilfe von reellen Zahlen beim Ubergang uber das Unendliche hinaus versagt. Deshalb stellt dieser Beitrag auch ein Pladoyer dafur dar, die Mathematik der surrealen Zahlen auf konkrete physikalische Situationen zu ubertragen, um ein Werkzeug zu erhalten, mit dem auch Unendliches und Groseres als unendlich sachangemessen beschrieben werden kann.
External Learning Activities and Team Performance: A Multimethod Field Study

This paper reports on a study of external team learning activities and their performance effects. It proposes and tests a model that consists of two sets of external learning activities: those that allow a team to learn from external experienced others about its task (vicarious learning activities) and those that allow a team to learn from external sources about its context (contextual learning activities). Qualitative data from six teams in one pharmaceutical firm are used to develop measures. Survey data from 62 additional teams in six other pharmaceutical firms are used, first to test the measurement model using structural equation modeling and second to test the relationships between external learning activities and team performance using random-effects regression models. Results show that vicarious learning activities are more strongly associated with performance when teams engage in more internal learning activities. Furthermore, vicarious learning activities in the absence of sufficient amounts of internal learning activities can hurt performance. The positive performance associated with contextual learning activities, by contrast, is unaffected by the level of internal learning activities. The paper contributes by distinguishing between two kinds of external learning activities and showing that they put different demands on teams to be effective. This is important because it helps us better understand how teams engage effectively in learning activities across their boundaries.
Novas propostas para otimização de receptores de TV digital baseados em OFDM em ambientes de redes de frequencia unica regionais

Esta tese trata da otimizacao de receptores de TV Digital baseados em OFDM, com avaliacao de desempenho em redes de retransmissao em frequencia unica (SFN . Single Frequency Networks) regionais. Tal ambiente facilita a distribuicao de canais, porem possui caracteristicas que dificultam o trabalho do receptor. Sao tratados, inicialmente, de projetos de filtros canceladores de elos de realimentacao em estacoes retransmissoras, que ocorrem quando a antena de transmissao interfere na antena de recepcao. Um novo filtro, baseado em tecnicas que utilizam informacao temporal e proposto. Novas propostas sao feitas para as partes de sincronismo, estimacao e equalizacao de canal, e codificacao/decodificacao. Uma tecnica, vinda da teoria de reconhecimento de padroes, e aplicada para diminuicao da complexidade no processo de sincronismo temporal. Um sistema de estimacao de canal 2D e equalizacao adaptativa, usando o LMS (Least Mean Square), e comparado com tecnicas classicas da literatura, e um ganho significativo e encontrado. Como novo esquema de codificacao e decodificacao e proposto um esquema iterativo, baseado em codigos turbo, com numero reduzido de iteracoes. Tal codigo melhora o desempenho do sistema em relacao ao uso combinado dos decodificadores Viterbi e Reed Solomon. Todas as propostas sao combinadas para se avaliar o desempenho do receptor diante de condicoes tipicas de SFN e multicaminhos tipicos em recepcao de TV do Brasil Abstract
Innovative Energy Harvester Design Using Bistable Mechanism With Compensational Springs In Gravity Field

The purpose of the presented work is to introduce the novel design of electrostatic energy harvester using bistable mechanism with compensational springs in gravity field capable of providing the output of several μW under the excitation of extremely small amplitude (up to 0.2g) and low frequency (10-100Hz). Presented energy harvester uses the bistable hysteresis modification to achieve low-frequency low-amplitude sensibility. It was demonstrated with finite element modelling (FEM) that hysteresis width produced by bistability is changing with a constant linear coefficient as a function of a compensational spring stiffness and thus a device sensitivity could be adjusted to the minimum point for the amplitude of external excitation. Further, highly non-linear bistable double curved beam mechanism assures the high sensitivity in frequencial domain due to the non-defined bandwidth. The equivalent circuit technique is used for simulating the device performance.
Competition‐Similarity Relationships and the Nonlinearity of Competitive Effects in Consumer‐Resource Systems

Much previous ecological and evolutionary theory about exploitative competition for a continuous spectrum of resources has used the Lotka‐Volterra model with competition coefficients given by a Gaussian function of niche separation. Using explicit consumer‐resource models, we show that the Lotka‐Volterra model and the assumption of a Gaussian competition‐similarity relationship both fail to reflect the impact of strong resource depletion, which typically reduces the influence of the most heavily used resources on the competitive interaction. Taking proper account of resource depletion reveals that strong exploitative competition between efficient consumers is usually a highly nonlinear interaction, implying that a single measure is no longer sufficient to characterize the process. The nonlinearity usually entails weak coupling of competing species when their abundances are high and equal. Rare invaders are likely to have effects on abundant residents much larger than those of the resident on the invader. Asymmetrical utilization curves often produce asymmetrical competition coefficients. Competition coefficients are typically non‐Gaussian and are often nonmonotonic functions of niche separation. Utilization curve shape and resource growth functions can have major effects on competition‐similarity relationships. A variety of previous theoretical findings need to be reassessed in light of these results.
Ultrahigh‐Throughput FACS‐Based Screening for Directed Enzyme Evolution

Directed enzyme evolution has proven to be a powerful tool for improving a range of properties of enzymes through consecutive rounds of diversification and selection. However, its success depends heavily on the efficiency of the screening strategy employed. Fluorescence‐activated cell sorting (FACS) has recently emerged as a powerful tool for screening enzyme libraries due to its high sensitivity and its ability to analyze as many as 108 mutants per day. Applications of FACS screening have allowed the isolation of enzyme variants with significantly improved activities, altered substrate specificities, or even novel functions. This review discusses FACS‐based screening for enzymatic activity and its potential application for the directed evolution of enzymes, ribozymes, and catalytic antibodies.
Role of O2 in regulating tissue respiration in dog muscle working in situ.

This study was designed to investigate the role of tissue oxygenation in some of the factors that are thought to regulate muscle respiration and metabolism. Tissue oxygenation was altered by reductions in O2 delivery (muscle blood flow x arterial O2 content), induced by decreases in arterial PO2 (PaO2). O2 uptake (VO2) was measured in isolated in situ canine gastrocnemius at rest and while working at two stimulation intensities (isometric tetanic contractions at 0.5 and 1 contractions/s) on three separate occasions, with only the level of PaO2 (78, 30, and 21 Torr) being different for each occasion. Muscle blood flow was held constant (pump perfusion) at each work intensity for the three different levels of PaO2. Muscle biopsies were obtained at the end of each rest and work period. Muscle VO2 was significantly less (P less than 0.05) at both stimulation intensities for the hypoxemic conditions, whereas [ATP] was reduced only during the highest work intensity during both hypoxemic conditions (31% reduction at 21 Torr PaO2 and 17% at 30 Torr). For each level of PaO2, the relationships between the changes that occurred in VO2 and levels of phosphocreatine, ADP, and ATP/ADP.P(i) as the stimulation intensity was increased were significantly correlated; however, the slopes and intercepts of these lines were significantly different for each PaO2. Thus a greater change in any of the proposed regulators of tissue respiration (e.g., phosphocreatine, ADP) was required to achieve a given VO2 as PaO2 was decreased. (ABSTRACT TRUNCATED AT 250 WORDS)
Forecasting with univariate time series models : a case of export demand for Peninsular Malaysia’s moulding and chipboard.

This study determines a suitable method from the univariate time series models to forecast the export demand of moulding and chipboard volume (m³) from Peninsular Malaysia using the quarterly data from March 1982 to June 2009. Export demand for moulding and chipboard were estimated using univariate time series models including the Holt-Winters Seasonal, ARAR algorithms and the seasonal ARIMA models. The seasonal ARIMA (1, 0, 4) X (0, 0, 1, 0)4 model produced the best forecast at the lowest forecast errors of MAPE, MAE and RMSE at 18.83%, 32730.8 and 35282.13, respectively. It forecasts the volume (m³) of moulding and chipboard for export to reach more than 150000 m3, and it is expected to be within range of 100000 to 250000 m3 at 95% confidence level. The forecasts assist in decision making process and facilitate a short-term marketing plan to meet the export demand from international market.