Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comparative Study of Virus Detection Techniques

The growing number of computer viruses and the detection of zero day malware have been the concern for security researchers for a large period of time. Existing antivirus products (AVs) rely on detecting virus signatures which do not provide a full solution to the problems associated with these viruses. The use of logic formulae to model the behaviour of viruses is one of the most encouraging recent developments in virus research, which provides alternatives to classic virus detection methods. In this paper, we proposed a comparative study about different virus detection techniques. This paper provides the advantages and drawbacks of different detection techniques. Different techniques will be used in this paper to provide a discussion about what technique is more effective to detect computer viruses. Keywords—computer viruses, virus detection, signature-based, behaviour-based, heuristic-based.
Osteotome sinus floor elevation and simultaneous placement of implants--a 1-year retrospective study with Astra Tech implants.

BACKGROUND The bone support for implants in the posterior part of the maxilla is often poor. This condition may be treated with augmentation of the maxillary sinus floor. The most common technique used is to elevate the sinus floor by inserting a bone graft through a window opened in the lateral antral wall, although less invasive techniques with osteotomes have been used since 1994. PURPOSE The aim of this study was to evaluate the clinical and radiographic outcome of implants placed in the posterior maxilla with the osteotome sinus floor elevation (OSFE) technique without grafting. MATERIALS AND METHODS The study population comprised 36 consecutive patients in whom 53 implants were inserted with the OSFE technique. The indication for sinus floor elevation was that the bone height below the maxillary sinus was considered to be 10 mm or less. RESULTS The mean height of the alveolar process in the intended implant sites was 6.3 +/- 0.3 mm, and the mean elevation of the sinus floor was 4.4 +/- 0.2 mm. At the 1-year follow-up, two implants had been lost, both in edentulous patients. The remaining 51 implants inserted were in function, giving a 1-year cumulative survival rate of 96%. Implants used in single-tooth replacements and in partially edentulous cases had a 100% survival rate. The mean marginal bone level at the time of loading of the implants was 0.1 +/- 0.04 mm below the reference point. One year later, the corresponding value was 0.5 +/- 0.06 mm. The mean bone loss between the two examinations was 0.4 +/- 0.05 mm. CONCLUSIONS The OSFE technique, without bone grafts, was found to produce predictable results in the treatment of 36 patients with restricted bone volume in the posterior part of the maxilla.
Buffer Planning for IP Placement Using Sliced-LFF

IP cores are widely used in modern SOC designs. Hierarchical design has been employed for the growing design complexity, which stimulates the need for fixed-outline floorplanning. Meanwhile, buffer insertion is usually adopted tomeet the timing requirement. In this paper, buffer insertion is considered with a fixed-outline constraint using Less Flexibility First (LFF) algorithm. Compared with Simulated Annealing (SA), our work is able to distinguish geometric differences between two floorplan candidates, even if they have the same topological structure. This is helpful to get a better result for buffer planning since buffer insertion is quite sensitive to a geometric change. We also extend the previous LFF to a more robust version called Sliced-LFF to improve buffer planning. Moreover, a 2-staged LFF framework and a post-greedy procedure are introduced based on our net-classing strategy and finally achieve a significant improvement on the success rate of buffer insertion (40.7% and 37.1% in different feature sizes). Moreover, our work is much faster than SA, since it is deterministic without iterations.
Relation between Total Quality Management Practices and Business Excellence: Evidence from Private Service Firms in Jordan

This study examines the extent of total quality management (TQM) practices implemented by private service firms and their impact on organisational excellence. Its importance derives from the major contribution of the private sector to the economy. TQM practices concerning leadership, human resource focus, process management, customer focus, and information and analysis found to have a positive effect on organisational excellence in the firms surveyed. This is the first study to examine the case of private sector firms offering specialized services, focusing on the KAAEPS. It will thus provide a model for private firms to improve their performance and motivate them to adopt TQM practices. It also provides a conceptual model for use by other researchers.
Phylogeny of LCR‐1 and OXA‐5 with class A and class D β‐lactamases

The nucleotide sequences of blaLCR‐1 and blaOXA‐5β‐lactamase genes have been determined. Polypeptide products of 260 and 267 amino acids with estimated molecular masses of 27 120 Da and 27387 Da were obtained for the mature form of LCR‐1 and OXA‐5 proteins. A progressive alignment was used to evaluate the extent of identity between LCR‐1 and OXA‐5 with 29 other β‐lactamase amino acid sequences. The data showed that both belong to class D. We identified amino acids conserved in 24 positions for class A β‐lactamases and in 28 positions for five class D enzymes. The structural similarities between class A and class D β‐lactamases are more extensive than indicated by earlier biochemical studies with overall 16% identity between both classes. From the alignment, dendograms were constructed with a distance‐matrix and parsimony methods which defined three major groups of proteins subdivided into clusters giving insight on β‐lactamase phylogeny and evolution.
The Role of Feedback in Managing the Internet-Based Volunteer Work Force

This paper explores a new phenomenon at the intersection of digital networks and organizations---the Internet-based volunteer work force---people who use Internet applications to pursue a personal interest through volunteering contributions of time and talent that may create value for organizations and their customers or members. This work force is not centrally organized, managed, or measured. It is an emergent phenomenon resulting from discretionary small actions taken by large numbers of people, enabled by technology and human initiative. This paper proposes a general framework for understanding the phenomenon and offers an empirical investigation of one component of it---the role of feedback in producing and sustaining high-quality contributions from this work force. In a comparative study of Internet-based voluntary technical support groups for software problems, we found that in groups who implement systematic quality feedback systems (compared to those that do not), question askers return over a longer duration, answer providers contribute more often, and technical problem resolution is more effective. We also found that with systematic feedback, volunteers who produce higher quality contributions have longer participation duration, and participation duration is positively associated with community maintenance contributions.
High-dose therapy and autologous stem-cell transplantation for adult patients with Hodgkin's disease who do not enter remission after induction chemotherapy: results in 175 patients reported to the European Group for Blood and Marrow Transplantation. Lymphoma Working Party.

PURPOSE To investigate the results of high-dose therapy and autologous stem-cell transplantation (ASCT) in adults with Hodgkin's disease who do not enter remission after induction therapy, to determine overall survival (OS) and progression free survival (PFS), and to identify prognostic factors. PATIENTS AND METHODS A retrospective analysis of 175 patients reported to the European Group for Blood and Marrow Transplantation between November 1979 and October 1995. One hundred were male and 75 were female, with a median age of 26.5 years. Responses to first-line therapy were defined as progressive disease (PD) in 88 and stable/minimally responsive disease (SD/MR) in 87. Seventy-five patients received ASCT after failure of one induction regimen. Second-line therapy was given to the remaining 100 patients. Response to second-line therapy was PD in 34 and SD/MR in 66. OS and PFS rates were determined, and prognostic factors were investigated using univariate and multivariate analyses. RESULTS Responses to high-dose therapy and ASCT were complete response (30%), partial response (28%), no response (14%), PD (14%), and toxic death (14%). Actuarial 5-year OS and PFS rates were 36% and 32%, respectively. In univariate analysis for PFS and OS, adverse factors were use of a second-line chemotherapy regimen and interval of more than 18 months between diagnosis and ASCT. In multivariate analysis, the interval between diagnosis and ASCT maintained prognostic significance for OS. Response to the chemotherapy regimen given immediately before ASCT had no predictive value. CONCLUSION High-dose therapy and ASCT is an effective treatment strategy for patients with Hodgkin's disease for whom induction chemotherapy fails. Outcome was equivalent for those with obvious PD or SD/MR in response to the regimen given immediately before high-dose therapy. Prospective randomized studies are required to compare this approach with conventional-dose salvage therapy.
Prevalence, risk factors and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) colonization in residents of long-term care facilities in Luxembourg, 2010

SUMMARY A prevalence survey of methicillin-resistant Staphylococcus aureus (MRSA) was performed in 2010 in 19 long-term care facilities in Luxembourg. Of the 954 participating residents, 69 (7·2%) were colonized by MRSA. Previous history of MRSA [odds ratio (OR) 7·20, 95% confidence interval (CI) 3·19–16·27], quinolone therapy in the previous year (OR 2·27, 95% CI 1·17–4·41) and ⩾24 h care administered per week (OR 4·29, 95% CI 1·18–15·56) were independent risk factors for MRSA colonization. More than 75% of strains were of clonal complex (CC)5, mainly spa-type t003 or sequence type (ST)225 and ST710, which is a rapidly emerging lineage prevalent in central Europe. Five residents were colonized by livestock-associated genotypes belonging to CC398. Previously dominant CC8 strains have recently been replaced by more resistant CC5 strains in Luxembourg.
The expression of p21/WAF-1 and cyclin B1 mediate mitotic delay in x-irradiated fibroblasts.

BACKGROUND To better understand the relationship between mitotic delay and the disruption of cyclin B1 and p21 in x-irradiated fibroblasts, studies were carried out to establish correlations between the downregulation of cyclin B1 by the cyclin kinase inhibitor (CKI) p21 and the induction of mitotic delay in the NIH3T3 fibroblast. MATERIALS AND METHODS Cell cycle kinetics were used to analyze mitotic delay in irradiated NIH3T3 cells and immunocytochemistry incorporated to assess the expression of cyclin B1 and p21, following 2 or 4 Gy x-irradiation. RESULTS AND DISCUSSION Results indicate a dose dependent increase in mitotic delay accompanied by a downregulation of cyclin B1 and corresponding upregulation of the CKI p21 in exponentially growing cultures. Data indicates that the induction of radiation-induced division delay appears to be dependent on the p21 inhibition of cyclin B1 and, furthermore, p21 and cyclin B1 expression are highly dependent on cell density.
HITM: A Hybrid Incentive Trade Model for Data Forwarding in DTNs

In delay tolerant networks (DTNs), the delivery rate and delivery speed are restricted by node selfishness. To promote the delivery rate and reduce the delivery delay in DTNs, we propose a hybrid incentive trade model (HITM), which uses reputation compensation to stimulate nodes to give up their temporary benefits and transfer their forwarding missions to other more qualified nodes. Furthermore, HITM gives credit payment and reputation promotion to nodes whose mission transferring behaviors are capable of reducing delivery delay or promoting delivery reliability, and conversely punishes nodes whose mission transferring behaviors could prolong the delivery delay or impair the delivery reliability. Trace-driven experiments are performed to compare HITM with previous representative incentive schemes. The experiment results demonstrate that the HITM can effectively limit node selfishness, thereby promoting the delivery rate as well as reducing the delivery delay.
Nuclear PTEN expression and clinicopathologic features in a population‐based series of primary cutaneous melanoma

Germline mutations of the PTEN tumor‐suppressor gene, on 10q23, cause Cowden syndrome, an inherited hamartoma syndrome with a high risk of breast, thyroid and endometrial carcinomas and, some suggest, melanoma. To date, most studies which strongly implicate PTEN in the etiology of sporadic melanomas have depended on cell lines, short‐term tumor cultures and noncultured metastatic melanomas. The only study which reports PTEN protein expression in melanoma focuses on cytoplasmic expression, mainly in metastatic samples. To determine how PTEN contributes to the etiology or the progression of primary cutaneous melanoma, we examined cytoplasmic and nuclear PTEN expression against clinical and pathologic features in a population‐based sample of 150 individuals with incident primary cutaneous melanoma. Among 92 evaluable samples, 30 had no or decreased cytoplasmic PTEN protein expression and the remaining 62 had normal PTEN expression. In contrast, 84 tumors had no or decreased nuclear expression and 8 had normal nuclear PTEN expression. None of the clinical features studied, such as Clark's level and Breslow thickness or sun exposure, were associated with cytoplasmic PTEN expressional levels. An association with loss of nuclear PTEN expression was indicated for anatomical site (p = 0.06) and mitotic index (p = 0.02). There was also an association for melanomas to either not express nuclear PTEN or to express p53 alone, rather than both simultaneously (p = 0.02). In contrast with metastatic melanoma, where we have shown previously that almost two‐thirds of tumors have some PTEN inactivation, only one‐third of primary melanomas had PTEN silencing. This suggests that PTEN inactivation is a late event likely related to melanoma progression rather than initiation. Taken together with our previous observations in thyroid and islet cell tumors, our data suggest that nuclear–cytoplasmic partitioning of PTEN might also play a role in melanoma progression. © 2002 Wiley‐Liss, Inc.
Localisation des interactions de rayonnements ionisants sur des fibres monocristallines scintillatrices

Le couplage entre un cristal scintillateur et un photodetecteur est devenu courant dans tous les domaines mettant en jeu la detection des particules de hautes energies (imagerie medicale, physique des hautes energies, etc. ). L'apparition de nouveaux systemes de cristallogeneses permettent desormais le developpement de cristaux scintillateurs sous formes de fibres (materiaux dont les diametres varient de quelques micrometres jusqu'a un millimetre pour des longueurs superieures au decimetre). Cette forme peu commune permet d'envisager de nouveaux types de detecteurs, plus precis et plus rapides (muni d'un photodetecteur place a chaque extremite de la fibre). La finalite du travail de these presente dans ce manuscrit a ete d'evaluer la potentialite de ce nouveau type de detecteurs. La premiere partie de ce rapport recapitule les differentes methodes de synthese de monocristaux, ainsi que les connaissances actuelles sur l'ensemble des processus de scintillation. Un deuxieme chapitre presente les resultats que nous avons obtenus dans l'etude d'un detecteur utilisant une fibre cristalline. Le troisieme chapitre est consacre a la comprehension des differents phenomenes physiques et optiques (scintillation, propagation de la lumiere dans la fibre, absorption) intervenant lors du processus de detection. Enfin, une derniere partie presente les resultats obtenus sur une nouvelle configuration de detecteur. Il ne s'agira plus ici de detecter des photons gamma mais des particules alpha, et de voir dans quelles mesures le changement de nature de la particule a detecter peut influer sur le processus de detection lui-meme
The ligand binding site and transduction mechanism in the inositol‐1,4,5‐triphosphate receptor.

The inositol‐1,4,5‐triphosphate (InsP3) receptor consists of a homotetramer of highly conserved 313 kd subunits that contain multiple transmembrane regions in the C‐terminal part of the protein. The receptor was expressed in COS cells and its domain structure was studied by mutagenesis. Deletion of the transmembrane regions from the receptor results in the synthesis of a soluble receptor protein that efficiently binds InsP3 but which instead of associating into homotetramers remains monomeric. This result suggests a role for the transmembrane regions in the association of the receptor subunits into tetramers but not in ligand binding. To localize the ligand binding site, further cDNAs encoding truncated receptor proteins were constructed. Assays of InsP3 binding to these truncated InsP3 receptors revealed that sequences in the N‐terminal fourth of the InsP3 receptor are sufficient for ligand binding. Accordingly, each subunit of the InsP3 receptor homotetramer contains an independent ligand binding site that is located on the N‐terminal ends of each subunit and is separated from the putative channel‐forming transmembrane regions by greater than 1400 amino acids. Gel filtration experiments demonstrate a large conformational change of the receptor as a function of ligand binding, suggesting a mechanism by which ligand binding might cause channel opening.
Cognitive Impairment in Mild General Paresis of the Insane: AD-Like Pattern

Background/Aims: We investigated the clinical and cognitive features of patients with mild general paresis of the insane (GPI) in comparison to Alzheimer’s disease (AD) patients, mild frontotemporal dementia (FTD) patients and normal elderly individuals. Methods: Twelve patients with mild GPI, 24 patients with mild AD, 11 patients with mild FTD and 36 healthy subjects participated in the current study. A comprehensive neuropsychological battery was used to assess memory, language, attention, executive function, visuospatial ability, etc. In addition, cranial MRI were also obtained from the 3 patient groups. Results: Mild GPI showed a similar pattern of cognitive impairments in memory, language and executive function to mild AD, but a mixed pattern of dissimilarities to mild FTD. Mild GPI patients had more complaints and positive signs in the nervous system than mild AD patients, and cranial MRI results showed that mild GPI patients usually had atrophy of the medial temporal lobe. Conclusion: There is an overall decline in cognitive functions of mild GPI patients, which is comparable to that in AD patients, suggesting that there is a wide range of structural changes in the brains of mild GPI patients as well. However, further studies are needed to verify whether these structural changes are similar to those in AD.
Rethinking the 5 R´s in Open Educational Resources: A Reuse Perspective

Open Educational Resources (OER) are digital learning resources available under public domain or open licenses that empower users with the 5Rs of freedom: reusing, reviewing, remixing, redistributing or retaining them for particular purposes. This paper states how reuse is related with the other Rs with the goal of paving the way to define traceability criteria for OER automatic quality evaluation.
Nano‐ and micro‐encapsulated systems for enhancing the delivery of resveratrol

There has been interest in the use of trans‐resveratrol as a natural preventative agent for improving health and alleviating a range of diseases. However, resveratrol has low bioavailability, and this has been associated with its poor water solubility, its low stability against environmental stress, and its inability to reach a target site in the body to exert the desired health effect. Encapsulation offers a potential approach for enhancing the solubility of resveratrol, stabilizing it against trans‐to‐cis isomerization, and improving its bioavailability. A range of encapsulant materials, formulations, and technologies have been examined for enhancing the delivery of resveratrol. Research on the efficacy of encapsulated resveratrol formulations and relevant doses for specific applications is required before recommendations may be made for the use of these formulations for human health outcomes.
Application of the Ijarah Contract on Educational Financing through Empowerment of Laboratory of Mini Sharia Bank in Higher Education

The focus of this study is aimed to find out the application of the educational funding Ijarah contract to student at Baytul Mal wat-Tamwil (BMT) as empowerment of Islamic mini bank laboratory in Higher Education. This research used descriptive qualitative methods by conducting interview, observation, and documentation. The results of the study indicate that the Ijarah contract is only applied to private universities. The students applying for educational funding must complete with a certificate from their Lecturer, Deputy Dean II and parents. The laboratory of Sharia Mini Bank analyzed the feasibility of educational funds submitted by students using the 5C principle (Capital, Collateral, Capacity, Character, and Condition). The application of the Ijarah contract by BMT University is permisible because BMT acts as renter as well as a renter to student at a new price (al-Ijarah al-Muwazi) or BMT is the liaison that takes care of the payment of student lectures. The benefits of BMT are obtained from the difference in rental prices or services for managing tuition fees (the Ijarah bil-Wakalah). The application of the ijarah contract in term financing of education through Universities. BMT has provided mutually beneficial solutions for students, Universities and BMT. Keywords—Ijarah contract; financing of education; empowerement; laboratory of mini Banking Syariah