Miracle-dz/UniFAR-FTUs huggingface dataset:
Delayed Cyst Formation after Radiosurgery for Cerebral Arteriovenous Malformation: Two Case Reports

Two patients who underwent gamma knife radiosurgery for ruptured cerebral arteriovenous malformations (AVM) developed cystic lesions at 78 and 111 months after undergoing treatment. Both patients presented initially with intracerebral hemorrhage. In one patient, the cystic lesion was discovered during routine follow-up imaging and clinical examination revealed homonymous hemianopsia; the second patient presented with seizure and the lesion was identified more than 9 years after radiosurgery. One patient underwent resection of the nidus and histologic analysis of the resected specimen showed vessels in various stages of obliteration. The present paper discusses the possible mechanism for the delayed development of cystic lesions, and the possibility that radiation-induced vascular changes may continue in a nidus even when angiography shows complete obliteration of the nidus.
Home enteral nutrition reduces complications, length of stay, and health care costs: results from a multicenter study.

BACKGROUND Home enteral nutrition (HEN) has always been recognized as a life-saving procedure, but with the ongoing economic crisis influencing health care, its cost-effectiveness has been questioned recently. OBJECTIVE The unique reimbursement situation in Poland enabled the otherwise ethically unacceptable, hence unavailable, comparison of the period of no-feeding and long-term feeding and the subsequent analyses of the clinical value of the latter and its cost-effectiveness. DESIGN The observational multicenter study in the group of 456 HEN patients [142 children: 55 girls and 87 boys, mean (±SD) age 8.7 ± 5.9 y; 314 adults: 151 women and 163 men, mean age 59.3 ± 19.8 y] was performed between January 2007 and July 2013. Two 12-mo periods were compared. During the first period, patients were tube fed a homemade diet and were not monitored; during the other period, patients received HEN. HEN included tube feeding and complex monitoring by a nutrition support team. The number of complications, hospital admissions, length of hospital stay, biochemical and anthropometric variables, and costs of hospitalization were compared. RESULTS Implementation of HEN enabled weight gain and stabilized liver function in both age groups, but it hardly influenced the other tests. HEN implementation reduced the incidence of infectious complications (37.4% compared with 14.9%; P < 0.001, McNemar test), the number of hospital admissions [1.98 ± 2.42 (mean ± SD) before and 1.26 ± 2.18 after EN; P < 0.001, Wilcoxon's signed-rank test], and length of hospital stay (39.7 ± 71.9 compared with 11.9 ± 28.5 d; P < 0.001, Wilcoxon's signed-rank test). The mean annual costs ($) of hospitalization were reduced from 6500.20 ± 10,402.69 to 2072.58 ± 5497.00. CONCLUSIONS The study showed that HEN improves clinical outcomes and decreases health care costs. It was impossible, however, to determine precisely which factor mattered more: the artificial diet itself or the introduction of complex care.
Sequential therapy with entecavir and PEG‐INF in patients affected by chronic hepatitis B and high levels of HBV‐DNA with non‐D genotypes

Complete eradication of hepatitis B virus (HBV) is rarely achieved. Treatment options include currently available nucleos(t)ide analogues and pegylated interferon. The aim of our exploratory study was to assess the effectiveness of sequential therapy for chronic hepatitis B (CHB) vs the current standard of care. We evaluated an association with entecavir and pegylated interferon alfa‐2a (PEG‐IFN) in 20 patients with hepatitis B, high HBV viremia and genotypes A, B, C and E. Patients received entecavir alone for 12 weeks, then entecavir and PEG‐IFN for 12 weeks, lastly PEG‐IFN alone for 36 weeks. The results were compared with 20 patients (control group) treated in the past with 48 weeks of PEG‐IFN monotherapy. Our results show that complete sustained virological response (SVR) and partial SVR were, respectively, 60% and 80% in the study group and 10% and 30% in the control group; anti‐HBe seroconversion rate were 76.9% vs 15%, and anti‐HBs seroconversion were 20% vs 0%, respectively. We found a correlation among different genotypes and virological and serological outcomes – genotype C has a better virological response, while genotype A had a better serological response, and E genotype had a poor response. These results show that a sequential approach is a promising strategy of treatment in patients with CHB and high viremia in comparison with PEG‐IFN monotherapy. The E genotype seems to have the worse rate of response and requires other treatment strategies.
Crosstalk Fault Detection for Interconnection Lines Based on Path Delay Inertia Principle

The crosstalk fault becomes more and more important in the deep submicron SoC and its detection involves sophisticated timing measurement. In this paper, a new test scheme to detect the crosstalk fault, based on the path delay inertia, for interconnection lines in SoC is proposed. The scheme, without using timing measurement, applies a transition on the aggressor line and a critical width pulse, CWP, to the victim line and detects the propagation of the CWP at the output of the victim line. The scheme is simple and simulation analysis and experiments show that it is effective in detecting crosstalk faults
Spatial data discovery using general purpose web search engines

To find spatial data, interested parties have to know where and how to access existing geospatial web services or geoportals. People in geographic information communities are aware of such online platforms, but what about others? Finding relevant spatial data that satisfy the needs of the requesters is still an issue. In this paper, we propose a method for documenting spatial data for both human and machine consumption. Through this method, a model for compiling spatial metadata based on the mapping between ISO 19115 spatial metadata standard and Dublin core is designed. The ultimate goal with this model is the documentation of spatial data in HTML for discovery by web search engines, but at the same time being understandable to users.
The role of ADAM17 in the T-cell response against bacterial pathogens

ADAM17 is a member of the A Disintegrin And Metalloproteinase family of proteases. It is ubiquitously expressed and causes the shedding of a broad spectrum of surface proteins such as adhesion molecules, cytokines and cytokine receptors. By controlled shedding of these proteins from leukocytes, ADAM17 is able to regulate immune responses. Several ADAM17 targets on T cells have been implicated in T-cell migration, differentiation and effector functions. However, the role of ADAM17 in T-cell responses is still unclear. To characterize the function of ADAM17 in T cells, we used Adam17fl/fl×CD4cre+ mice with a T-cell restricted inactivation of the Adam17 gene. Upon stimulation, ADAM17-deficient CD4+ and CD8+ T cells were impaired in shedding of CD62L, IL-6Rα, TNF-α, TNFRI and TNFRII. Surprisingly, we could not detect profound changes in the composition of major T-cell subsets in Adam17fl/fl×CD4cre+ mice. Following infection with Listeria monocytogenes, Adam17fl/fl×CD4cre+ mice mounted regular listeria-specific CD4+ TH1 and CD8+ T-cell responses and were able to control primary and secondary infections. In conclusion, our study indicates that ADAM17 is either not required in T cells under homoeostatic conditions and for control of listeria infection or can be effectively compensated by other mechanisms.
Social-oriented adaptive transmission in wireless ad hoc networks

Cooperation among nodes plays an important role in the commercial development of wireless networks. Efficient cooperation should include not only encouraging selfish nodes to forward packets for one another but also selecting optimal transmission methods. Therefore, in this paper, in order to improve network performance, we propose a social-oriented adaptive transmission scheme for wireless ad hoc networks. Firstly, next-hop node for each transmission is decided by a double auction-based social awareness mechanism. Then in the case of relay-aided transmissions, optimal relaying method is selected by jointly considering network coding and spectrum spatial reuse. Simulation results demonstrate that the proposed scheme has significant advantages in social welfare and throughput improvement.
Ten Year Follow-up for a Patient Postmatched Unrelated Donor Bone Marrow Transplant Followed by Same Donor Kidney Transplant: Normal Renal Function Without Immunosuppression.

T is supportive data in transplant literature describing induction of donor tolerance with sibling matched hematopoietic stem cell transplant (HSCT) before renal solid organ transplantation without ongoing immunosuppression. To our knowledge, this case report is the first longterm follow-up for a patient receiving a matched unrelated bone marrow transplantation followed by a kidney transplant from the same donor. The patient is a female who was diagnosed with acute myeloid leukemia-M4 at 14 years of age. Initially, she went into remission after induction chemotherapy, but 6 months later and after the fourth cycle of chemotherapy, she had a bone marrow relapse. The initial reinduction chemotherapy did not result in a remission. However, with a single dose of 9 mg/m gemtuzumab ozagamicin (Mylotarg), a remission was achieved. She then received conditioning with 1350 cGy TBI, 18 g/m cytarabine, and 90 mg/kg cyclophosphamide, followed by a 10/10 allelematched unrelated donor bonemarrow transplantation. Methotrexate and cyclosporine were used for graft-versus-host disease (GvHD) prophylaxis. Three weeks after transplantation, she developed BK virus–associated hemorrhagic cystitis. Five weeks after HSCT, she developed grade IV acute GvHD of skin and gut which required a protracted course of immunosuppressive therapy, including steroids, calcineurin inhibitors, daclizumab, and lactoferrin. Soon thereafter, she developed end-stage renal disease, and hemodialysis was started. At that time, as supported by National Marrow Donor Program guidelines, she did communicate with her bone marrow donor. The interaction
Disorganization of the Golgi complex and the cytoplasmic microtubule system in CHO cells exposed to okadaic acid.

A combination of immunocytochemical and electron microscopic methods was used to study the effects of okadaic acid, a specific inhibitor of protein phosphatase types 1 and 2A, on the Golgi complex and the microtubule system of interphase CHO cells. At a concentration of 0.25 microM and within 2-3 h of exposure, okadaic acid caused a reversible disorganization of the Golgi complex, observed as a disintegration of the stacks of cisternae and formation of clusters of tubules and vesicles dispersed in the cytoplasm. At the same time, staining for mannosidase II was shifted from the Golgi stacks to the endoplasmic reticulum, whereas the clusters of tubules and vesicles for the main part were negative. This change in localization of the enzyme was not blocked by cycloheximide and thus not dependent on ongoing protein synthesis. The changes in the morphology of the Golgi complex were coordinated in time with a remodelling of the microtubule system, observed as a reduction in the number of microtubules, a tendency of the remaining microtubules to arrange in an aster-like pattern, and an increased sensitivity to low concentrations of the microtubule-disruptive drug nocodazole. After removal of the drug, the microtubule system was rapidly normalized (1-2 h) and subsequently also the Golgi complex (4-8 h). The results suggest that okadaic acid induces a redistribution of the Golgi stacks into the endoplasmic reticulum, leaving the trans-most elements behind as tubules and vesicles. (ABSTRACT TRUNCATED AT 250 WORDS)
The incidence of sensory integrative dysfunction among children with orofacial cleft.

Occupational therapists working with children with clefts observed that those children demonstrated subtle developmental delays, including learning, language, and behavioral problems that appeared related to sensory integrative dysfunction as identified by Ayres in children with learning disabilities. This study explored the possible existence of sensory integrative dysfunction in children with clefts when compared to normative data published by Ayres. The Southern California Sensory Integration Tests and the Southern California Postrotary Nystagmus Tests were administered to 70 four- to nine-year old children with clefts, who had been selected from four different hospital settings. Comparisons of the mean subtest scores of the sample children and the norms showed that significant levels (p less than .05) of difference existed. The subjects with clefts exhibited dysfunction related to vestibular and tactile processing and bilateral integration. No relationship was found between sensory integrative dysfunction and the child's cleft type, sex, or hospital setting.
From Biomass-Derived Furans to Aromatics with Ethanol over Zeolite.

We report a novel catalytic conversion of biomass-derived furans and alcohols to aromatics over zeolite catalysts. Aromatics are formed via Diels-Alder cycloaddition with ethylene, which is produced in situ from ethanol dehydration. The use of liquid ethanol instead of gaseous ethylene, as the source of dienophile in this one-pot synthesis, makes the aromatics production much simpler and renewable, circumventing the use of ethylene at high pressure. More importantly, both our experiments and theoretical studies demonstrate that the use of ethanol instead of ethylene, results in significantly higher rates and higher selectivity to aromatics, due to lower activation barriers over the solid acid sites. Synchrotron-diffraction experiments and proton-affinity calculations clearly suggest that a preferred protonation of ethanol over the furan is a key step facilitating the Diels-Alder and dehydration reactions in the acid sites of the zeolite.
Bimodal Score Distributions and the Myers-Briggs Type Indicator: Fact or Artifact?

We examined Myers-Briggs Type Indicator (MBTI) score distributions computed using item response theory (IRT) to assess the generalizability of earlier bimodality reports that have been cited in support of the "type" versus "trait" view of personality. Using the BILOG IRT program to score a sample of approximately 12,000 individuals who participated in leadership development programs, q score distributions for the 4 dimensions of the MBTI computed using 10 (the BILOG default) versus 50 quadrature points were compared. Results indicated that past reports of bimodality were artifacts caused by BILOG's default use of a small number of quadrature points; when larger numbers of points were used, score distributions became strongly center-weighted. Although our findings are not supportive of the "type"-based hypothesis, the extremely high correlations between q scores (rs > .996) suggest that no practical differences would be expected as a function of the number-of-quadrature-points decision.
Le logement social au Nunavik : pouvoirs et responsabilités

Cet article etudie la participation des acteurs regionaux a l’elaboration et a la mise en oeuvre de l’Entente concernant la mise en oeuvre de la Convention de la Baie-James et du Nord quebecois en matiere de logement au Nunavik. Cette entente est centrale, d’un point de vue politique, pour comprendre la situation du logement au Nunavik, puisqu’elle fixe les roles de chacun des acteurs et etablit le financement accorde pour la construction des logements sociaux. L’entente signee en 2000 a ete renouvelee par deux fois, soit en 2005 et en 2010. Si elle avait pour but, lors de sa signature, de repondre aux besoins du Nunavik en logements, la mise en place en 2011 d’un mecanisme de resolution des differends et l’absence d’accord pour le renouvellement de l’entente quinquennale en 2015 sont des signes qu’elle ne rencontre pas les objectifs souhaites par l’ensemble des signataires. En ce sens, par une analyse historique de l’entente, les auteurs souhaitent mettre en lumiere les pouvoirs que les differents acteurs regionaux exercent a travers cette politique et les differends qui les separent.
An Efficient Approach to Calculate Leakage Current Based on SPICEs Parameters at CMOS Transistors

The main idea of this paper is to discuss a new approach to optimize the value of leakage current in MOS transistors. It based on looking for optimal values of the main SPICE parameters which influence the value of the leakage current. These Values make in totally the leakage current, minimal value. The logic and the flow diagrams seem working correctly; various simulation results show the validity of the proposed technique and the value of the leakage is reduced finally as expected.
Effects of the marihuana‐homologue, pyrahexyl, on open field behaviour in the rat

Four concentrations of pyrahexyl(2.5, 5.0, 10.0 and 15.0 mg/kg) dissolved in olive oil, were administered intraperitoneally to four groups of Long Evans hooded rats 2-3 months old of either sex. There were two males and two females in each group. A fifth control group received only olive oil. The rats were observed 2+ h after injection for 5 min in a 30 x 18; x 18 inch open field which had been marked off in squares. Four measures of behaviour were recorded : activity as defined by the number of lines a rat crossed with both hind feet ; rearing, which was scored whenever the animal stood on its hind legs for any purpose other than grooming; grooming, defined as any response involving the smoothing of the fur or bring the forefeet to the face for the purpose of “washing” ; and defaecation. The evidence was examined by a one-way analysis of variance (Hays, 1965). A dosedependent effect of pyrahexyl on activity (F = 7.01, df = 4.15, P < 0.01) was found. At lOmg/kg there was no noticeable difference in activity between the treated and untreated rats. However, at 2-5 and 5 mg/kg of pyrahexyl, activity was increased above the control values whereas at 15 mg/kg, activity was depressed. Rearing was also affected significantly by pyrahexyl (F = 26.79, df = 4, 15, P < 0.01), a progressive inhibitory effect being seen as the dosage increased, 10-15 mg/ kg of the drug inhibiting rearing by 50%. Neither grooming nor defaecation was significantly affected. The relation between dosage level and activity is complex ; the change in activity response with dose demonstrates how different conclusions about the effects of pyrahexyl could be reached according to dosage. But as rearing was progressively suppressed as drug dosage was increased, various behavioural responses appear to be differentially affected by the drug. Walters & Abel(l970) found that while pyrahexyl did not affect jumping behaviour itself, it did reduce the latency in the jumping response of gerbils to a stimulus which signalled the onset of shock. But, with rats, Abel & Schiff (1969) found pyrahexyl increased the amount of time spent in observing other animals. It appears then, that the affects of pyrahexyl are not only dose-dependent but are also response specific.
Proteomics of Physcomitrella patens protonemata subjected to treatment with 12-oxo-phytodienoic acid

12-Oxo-phytodienoic acid (OPDA) is induced by mechanical wounding and suppresses the growth of Physcomitrella patens; OPDA is considered as a signal compound in this moss species. In this study, a proteomic analysis of P. patens protonemata treated with OPDA was performed. The abundance levels of 41 proteins were significantly altered by OPDA, with decreased levels for 40 proteins. The proteins for which abundance decreased in response to OPDA at the protonema developmental stage were mainly involved in the metabolism of proteins and carbohydrates. The effects of inhibition on protein abundance are likely a major physiological function of OPDA in P. patens. OPDA also suppressed the expression of histones at the protein level and gene transcription level. Suppression of histone expression might be an OPDA-specific function in P. patens protonemata. In P. patens, a subset of the physiological responses caused by OPDA is shown to differ between protonema and gametophore developmental stages. Graphical abstract Classification of OPDA-regulated proteins in Physcomitrella patens protonema according to their functions.
Very high performance non-volatile memory on flexible plastic substrate

We report very high performance non-volatile memory on flexible plastic substrate, with ultra-low 5 µW switching power (1.6 µA at 3 V; −0.5 nA at −2 V), excellent 10<sup>5</sup> cycling endurance, large on/off retention memory window >10<sup>2</sup> even at 85°C, and fast 50 ns switching for the first time. These were achieved using Ni/GeO<inf>x</inf>/HfON/TaN RRAM on low cost plastic that has simple MIM structure, low cost electrodes and covalent-bond-dielectric/metal-oxide.
HUMAN HYDATIDOSIS IN BENGHAZI, LIBYA: AN EPIDEMIOLOGICAL STUDY OF SURGICAL CASES BETWEEN 2000 AND 2007 -

Echinococcosis or hydatid cyst (HC) is considered one of the major parasitic infections in Libya that causes many health problems and economic losses in communities. The aim of the present study was to determine the prevalence of HC in patients referred to surgery in three hospitals in Benghazi from 2000 â€“ 2007. The study was conducted on 329 patients diagnosed with hydatid cyst disease and treated surgically at the three hospitals. Cystic echinococcosis (CE) affected more females 205 (62.31%) than males 124 (37.69%). Cysts were found in liver and lung in 61.8% and 31.6% of cases, respectively. In addition, cysts were found in brain, muscle, kidney eye, and peritonea in the remaining 6.6% of cases. A significantly higher number of hydatid cysts were recorded in the liver than in other sites (P
Incorporating Practice Theory in Sub-Profile Models for Short Term Aggregated Residential Load Forecasting

Aspirations of grid independence could be achieved by residential power systems connected only to small highly variable loads if overall demand on the network can be accurately anticipated. Absence of the diversity found on networks with larger load cohorts or consistent industrial customers makes such overall load profiles difficult to anticipate on even a short term basis. Here, existing forecasting techniques are employed alongside enhanced classification/clustering models in proposed methods for forecasting demand in a bottom up manner. A Markov chain based sampling technique derived from practice theory of human behavior is proposed as a means of providing a forecast with low computational effort and reduced historical data requirements. The modeling approach proposed does not require seasonal adjustments or environmental data. Forecast and actual demand for a cohort of residential loads over a five-month period are used to evaluate a number of models, as well as demonstrate a significant performance improvement if utilized in an ensemble forecast.