Miracle-dz/UniFAR-FTUs huggingface dataset:
A case of lethal hemolytic anemia associated with severe pneumonia caused by Mycoplasma pneumoniae.

T the editor: A 31-year-old previous healthy male patient was admitted to the hospital with fever (Tmax 41°C) and nonproductive cough for seven days and dyspnea for three days. On day 4 after disease onset, his chest X-ray showed right upper lung small opacity and left lung large opacity (Figure 1A). The patient has been administrated levofloxacin for two days before he came into our hospital. Upon physical examination, blood pressure was 76/45 mmHg, pulse rate was 110/minute, respiratory rate was 35 breaths/min and temperature was 39.0°C. Chest examination showed bilateral fine moist rales and sporadic dry rales. Lab results showed that white blood cell (WBC) count was 8.86×10 with 82.7% neutrophils, platelet count 127×10/mm and hemoglobin 133 g/dl. Blood chemistry including liver profile, kidney profile, and coagulation studies were within normal limits. The chest X-ray showed progressive infiltration with left lung extensive consolidation (Figure 1B). Artery blood gas on non-rebreath oxygen face mask with 10 L/min oxygen flow rate showed PH 7.457, PaO2 77.8 mmHg, PaCO2 29.7 mmHg, and HCO3 –21.2 mmol/L. Infection work-ups were initiated thoroughly and finally sputum PCR for Mycoplasma pneumoniae (M. pneumoniae) was strong positive and serum IgM antibody for M. pneumoniae was also positive. Upon coming into our hospital, only moxifloxacin (0.4 g once daily intravenously) and oxygen therapy were administrated. Three days later on day 10 after onset, patient symptoms were significantly improved. However, at night on day 10, the patient presented passing dark urine and jaundice next early morning. Lab analysis showed WBC count was 28.87×10 with 67% neutrophils, platelet count 127×10/mm and hemoglobin 82 g/dl, high LDH level (1388 U/L) and hyperbilirubinemia (TBIL 73.9 μmol/L, IBIL 47.40 μmol/L, and DBIL 26.50 μmol/L). The blood smear showed red cell agglutination (Figure 1C). So hemolytic anemia was concerned and was treated by intravenous methylprednisolone (80 mg, Q12h) and immunoglobulin (35 g/d). Unfortunately, the hemoglobin quickly dropped to 3.2 g/dl in the following 36 hours and IBIL elevated to 9.56 μmol/L even received 240 mg methylprednisolone. A Coombs test was positive only for complement. The patient was transferred into ICU for plasmapheresis. After three-time plasmapheresis and steroids decrement to 40 mg/d, the patient’s hemoglobin did not drop again and gradually went up to 4.3 g/L and bilirubin came down to normal level and went back general ward. He was discharged with hemoglobin 8.2 g/dl on day 23. Before he was discharged, a cold agglutinin test was found to be positive with antibody titre 1: 512. The patient was followed on day 30 after onset. He recovered very well and hemoglobin reached 12.3 g/dl. Lung field was also clear (Figure 1D).
Performance Optimization of Onboard Lithium Ion Batteries for Electric Vehicles

Next generation of transportation in the form of electric vehicles relies on better operation and control of large battery packs. The individual modules in large battery packs generally do not have identical characteristics and may degrade differently due to manufacturing variability and other factors. Degraded battery modules waste more power, affecting the performance and economy for the whole battery pack. Also, such impact varies with different trip patterns. It will be cost effective if we evaluate the performance of the battery modules prior to replacing the complete battery pack. The knowledge of the driving cycle and battery internal resistance will help to make decision to replace the worst battery modules and directly cut down on user expenditure to replace the battery. Also, optimizing the performance of battery during the driving trip is the challenging task to achieve. The knowledge of energy prices of the grid, internal resistance of the lithium ion battery pack on the electric vehicle, the age of the battery and distance travelled by the electric vehicle are very important factors on which the cost of daily driving cycle is dependent. In near future, the energy consumed by the electric vehicles will create a major consumer market for the smart grids. The smart grid system is complemented by the renewable energy sources that contribute and support the grid. The electric vehicles are not only predicted as energy consumers but also as dynamic sources of energy. These vehicles can now travel more than 100 miles with a single charging cycle whereas average day to day commute is well below the maximum capacity of these vehicles. This leaves the driver with the extra energy on the battery pack which can be used later for supporting energy requirement from the grid. As we know that cells/modules in large battery packs do not have identical properties and these degrade at different rates during the course of their lifespan. It is beneficial for the user to quantify the amount of energy that can be used to support the grid. The improvement of the electric grid to the next generation infrastructure ie ‘Smart Grid’ will enable diverse opportunities to contribute the energy and balance the load on the grid. The information about the grid like price quality, load etc will be available to the people very easily. This information can be useful to make the energy grid more economical and environment friendly. We have used the information for price of energy on the grid to optimize the cost of daily driving cycle. The goal of this research is to accurately predict the battery behavior for the daily driving cycle. The prediction of battery behavior will help the driver to decide the optimum charging patterns, energy consumed during driving and the surplus energy available in the batteries. The prior knowledge of the battery behavior, price of the energy on the grid and the trip travel will help the driver to minimize the cost of travel on daily basis as well as throughout the life of the…
Genotyping by dynamic heating of monolayered beads on a microheated surface

A miniaturized bead‐based dynamic allele‐specific hybridization (DASH) approach for single‐nucleotide polymorphism analysis is presented. Chips with integrated heater and temperature sensors for open‐surface DNA analysis were microfabricated. Microcontact printing using a poly(dimethylsiloxane) (PDMS) stamp was employed to create monolayers of immobilized beads on the surface of the chip. This chip allows fast, well‐controllable temperature ramping. The temperature distribution was homogeneous over the entire heater area. All three possible variants of an SNP site of a synthesized oligonucleotide were accurately scored using the bead‐based DASH approach. Our assay has a nonoptimized temperature ramping rate of 4°C–6°C/min compared to earlier reported values of 2°C–3°C/min, thereby reducing the total analysis time by a factor of 2. Reliable DASH measurement data from areas as small as 12×13 μm was achieved. Our bead‐based DASH approach has enabled a dramatic volume reduction and is a step towards developing a cost‐effective high‐throughput DASH method on arrays of single beads.
Audience Segmentation of Kentucky Mothers by Nonparticipation Status in the Special Supplemental Nutrition Program for Women, Infants, and Children

ABSTRACT We identify women most and least likely to discontinue participation in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) program. Kentucky WIC program management information system data from 2012 to 2013 was explored through a retrospective cohort study. Audience segmentation identified unique groups with respect to nonparticipation. Presumptive eligibility for Medicaid was the strongest predictor of nonparticipation. Among those who were not presumptively eligible, women who were the only ones in their households enrolled in the program were at higher risk of nonparticipation. Outreach strategies at the point of enrollment or when presumptive eligibility for Medicaid is granted could mitigate further nonparticipation.
An HMM/DNN Comparison for Synchronized Text-to-Speech and Tongue Motion Synthesis

We present an end-to-end text-to-speech (TTS) synthesis system that generates audio and synchronized tongue motion directly from text. This is achieved by adapting a statistical shape space model of the tongue surface to an articulatory speech corpus and training a speech synthesis system directly on the tongue model parameter weights. We focus our analysis on the application of two standard methodologies, based on Hidden Markov Models (HMMs) and Deep Neural Networks (DNNs), respectively, to train both acoustic models and the tongue model parameter weights. We evaluate both methodologies at every step by comparing the predicted articulatory movements against the reference data. The results show that even with less than 2h of data, DNNs already outperform HMMs.
Genetic variants in the integrin gene predicted microRNA‐binding sites were associated with the risk of prostate cancer

microRNAs (miRNA) silence target genes through Watson–Crick based binding to the 3'untranslated regions (3′UTR). Thus, polymorphisms in the miRNA‐binding sites may disrupt this process and play a potential role in cancer pathogenesis. Integrins have been implicated in the genesis and development of many tumors. This study was designed to evaluate the association between five SNP loci in predicted miRNA‐binding sites in five integrin genes and prostate cancer occurrence and prognosis to provide data for screening high‐risk Chinese Han individuals. These five polymorphisms were genotyped by using the high‐resolution melting method (HRM) in 347 Chinese Han prostate cancer patients with long‐time follow‐up together with 367 age‐matched healthy controls. GC carriers of rs11902171 in ITGAv were associated with a decreased risk of prostate cancer (OR 0.57, 95% CI 0.35–0.93). However, no significant difference was detected in genotype distributions of the five SNP loci in the progression‐free survival time of prostate cancer. The ITGAv gene SNP rs11902171 may be potentially associated with the risk of prostate cancer. © 2012 Wiley Periodicals, Inc.
Burden of dizziness and vertigo in the community.

BACKGROUND Dizziness and vertigo are common, however, the cause often remains unexplained. The percentage of vertigo of vestibular origin in individuals with unselected dizziness has not been well examined, and its underestimation may lead to diagnostic bias in primary care. The purpose of this study was to reassess the burden of dizziness in the community and to quantify the contribution of vertigo of vestibular origin. METHODS A nationally representative sample of 4869 adults living in Germany was screened for moderate or severe dizziness, and 1003 individuals with dizziness underwent validated neurotologic interviews to differentiate vestibular vertigo from nonvestibular dizziness according to explicit diagnostic criteria. RESULTS Dizziness/vertigo had a prevalence of 22.9% in the last 12 months and an incidence (first episode of dizziness/vertigo) of 3.1%. For vestibular vertigo, the prevalence was 4.9% [corrected] and the incidence was 1.4%. We also found that 1.8% of unselected adults consulted a physician in the last 12 months for [corrected] dizziness/vertigo (0.9% for vestibular vertigo). Compared with nonvestibular dizziness, vestibular vertigo was more frequently followed by medical consultation (70% vs 54%; P < .001), sick leave (41% vs 15%; P < .001), interruption of daily activities (40% vs 12%; P < .001), and avoidance of leaving the house (19% vs 10%; P = .001). However, more than half of the participants with vestibular vertigo reported nonvestibular diagnoses. Age- and sex-adjusted health-related quality of life was lower in individuals with dizziness and vertigo compared with dizziness-free control subjects. CONCLUSIONS The occurrence of dizziness and vertigo is frequent and associated with a considerable personal and health care burden. Vestibular vertigo accounts for a considerable percentage of this burden, which suggests that diagnosis and treatment of frequent vestibular conditions are important issues in primary care.
Home Values and Firm Behavior

The homes of firm owners are an important source of finance for ongoing businesses. We use UK microdata to show that a £1 increase in the value of the homes of a firm’s directors increases the firm’s investment by £0.03. This effect is concentrated among firms whose directors’ homes are valuable relative to the firm’s assets, that are financially constrained, and that have directors who are personally highly levered. An aggregation exercise shows that directors’ homes are as important as corporate property for collateral driven fluctuations in aggregate investment demand. (JEL D22, D25, E22, G31, G34, R31)
Rapid, Multiwell Colorimetric Assay for Measuring Neutrophil Chemoattractant Activity in Bronchoalveolar Lavage Fluid of Horses with Recurrent Airway Obstruction

The criteria used to diagnose recurrent airway obstruction (RAO) in affected horses include demonstration of reversible lower airway obstruction and greater than 25% neutrophils in bronchoalveolar lavage fluid (BALF). Additional objective laboratory tests are needed to improve diagnostic accuracy and to monitor response to treatment. The goal of this study was to determine if neutrophil chemoattractant activity of BALF could be measured by using a previously described, rapid, multiwell colorimetric assay for chemotaxis. In this assay, neutrophils that have migrated through a membrane filter are collected into the bottom well of a disposable chemotaxis–cell migration chamber. The number of viable cells collected in the bottom well is quantified by measurement of the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenol tetrazolium bromide (MTT), which is reduced by dehydrogenase in mitochondria of live cells. The number of migrating cells corresponds to the amount of MTT reduced, which is measured with an enzyme-linked immunosorbent assay plate reader. Fourteen adult horses were enrolled in this study, 7 of which had owner histories consistent with RAO. Each horse was sedated, a bronchoalveolar lavage tube was passed, and saline was infused and immediately aspirated. An aliquot of BALF was used for differential cell count, and BALF supernatant was harvested to assess neutrophil chemoattractant activity. Normal control horses and RAO-affected horses were distinguished according to clinical signs and percent neutrophils in BALF. Neutrophil chemoattractant activity of BALF was significantly greater in RAO-affected horses (P = 0.001) compared with control horses. This assay may be useful in future studies for monitoring response to therapy in RAO-affected horses.
Utilization of DEMATEL and WINGS Method in Field of Corporate Social Responsibility

Corporate Social Responsibility has become an integral part of many organizations. The CSR concept can be generally understood as a willing obedience of responsible behavior and social engagement at regional, state and global level, as well. A broad thematic range of the CSR concept interconnecting a large quantity of scientific fields and expert opinions leads to a terminological disunity resulting in many various definitions. An exact measurement is a very questionable and difficult task. The main goal of this paper is to compare applications of DEMATEL and WINGS method used for the CSR performance measurement, identify possible relations among selected CSR activities from a managerial point of view according to results of those methods and determine key factors of successful CSR strategy for banking organizations. Both methods belong to multiple-attribute decision-making methods (MADM methods) that are based on a usage of pairwise comparisons. Results show that the economic field is the most important factor, while safety, ethical codes, ecological innovations, management and certifications, and employee welfare belong to the key CSR criteria.
The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma

Allergic asthma is a chronic airway disorder characterized by airway inflammation, mucus hypersecretion, and airway hyperresponsiveness (AHR). A murine model of asthma was used to examine the antiasthmatic effect of inhaled inactived Mycobacterium phlei (M. phlei). AHR, neutrophil levels, eosinophil levels and levels of interleukin (IL)-17 and IL-23 receptor (IL-23R) were monitored. The results demonstrated that inactivated M. phlei alleviates the IL-17+γδT cell-mediated immune response and attenuates airway inflammation and airway hyperresponsiveness in the asthmatic murine lung, partially through inhibiting the expression of IL-23R. In conclusion, inactivated M. phlei may be an effective antiasthmatic treatment, regulating IL-17-producing γδT (IL-17+γδT) cell-mediated airway inflammation and airway hyperresponsiveness to relieve the symptoms of mice with asthma.
SIVsm Quasispecies Adaptation to a New Simian Host

Despite the potential for infectious agents harbored by other species to become emerging human pathogens, little is known about why some agents establish successful cross-species transmission, while others do not. The simian immunodeficiency viruses (SIVs), certain variants of which gave rise to the human HIV-1 and HIV-2 epidemics, have demonstrated tremendous success in infecting new host species, both simian and human. SIVsm from sooty mangabeys appears to have infected humans on several occasions, and was readily transmitted to nonnatural Asian macaque species, providing animal models of AIDS. Here we describe the first in-depth analysis of the tremendous SIVsm quasispecies sequence variation harbored by individual sooty mangabeys, and how this diverse quasispecies adapts to two different host species—new nonnatural rhesus macaque hosts and natural sooty mangabey hosts. Viral adaptation to rhesus macaques was associated with the immediate amplification of a phylogenetically related subset of envelope (env) variants. These variants contained a shorter variable region 1 loop and lacked two specific glycosylation sites, which may be selected for during acute infection. In contrast, transfer of SIVsm to its natural host did not subject the quasispecies to any significant selective pressures or bottleneck. After 100 d postinfection, variants more closely representative of the source inoculum reemerged in the macaques. This study describes an approach for elucidating how pathogens adapt to new host species, and highlights the particular importance of SIVsm env diversity in enabling cross-species transmission. The replicative advantage of a subset of SIVsm variants in macaques may be related to features of target cells or receptors that are specific to the new host environment, and may involve CD4-independent engagement of a viral coreceptor conserved among primates.
Childhood Health Consequences of Maternal Obesity during Pregnancy: A Narrative Review

Background: Obesity is a major public health problem among women of reproductive age. In a narrative review, we examined the influence of maternal obesity during pregnancy on fetal outcomes and childhood adiposity, cardio-metabolic, respiratory and cognitive-related health outcomes. We discuss results from recent studies, the causality and potential underlying mechanisms of observed associations and challenges for future epidemiological studies. Summary: Evidence from observational studies strongly suggests that maternal pre-pregnancy obesity and excessive gestational weight gain are associated with increased risks of fetal pregnancy complications and adverse childhood cardio-metabolic, respiratory and cognitive-related health outcomes. It remains unclear whether these associations are due to intrauterine mechanisms or explained by confounding family-based sociodemographic, lifestyle and genetic factors. The underlying mechanisms have mainly been assessed in animal studies and small human studies, and are yet to be further explored in large human studies. Key Message: Maternal obesity is an important modifiable factor during pregnancy that is associated with a variety of adverse offspring health outcomes. Further studies are needed to explore the causality and underlying mechanisms of the observed associations. Ultimately, preventive strategies focused on reducing maternal obesity and excessive weight gain during pregnancy may reduce common diseases in future generations.
A pilot finite element study of an osteoporotic L1-vertebra compared to one with normal T-score

In this paper, two patient-specific finite element (FE) models of both an L1 vertebra with a normal T-score and a mildly wedging, osteoporotic one were created and analysed under usual action. Utilising commercial software packages for image processing and FE analysis (FEA) along with in house computer codes for a posteriori assignment of material properties, in vivo high-resolution spiral computed tomography of the entire vertebrae and FEA were combined. Using the vertebra with a normal T-score as baseline it was found that the maximum value of the von Mises stress in the osteoporotic vertebra was 60% higher but still far below bone strength, while the maximum value of von Mises strain in the same vertebra was 148% higher than that of the vertebra with normal T-score. In the vertebra with normal T-score, 17% of its volume exhibited values of von Mises strain higher than the threshold of 4500 μstrains, referenced by Homminga et al. as a threshold of fracture risk, while in the osteoporotic one this percentage was raised up to 37%. The results suggested that the osteoporotic vertebra is susceptible to fracture due to raised strains and not stresses.
Relevance of Capital Structure Theories in the Service Sector

The aim of this study is to examine the relevance of capital structure theories in the Hungarian service sector between 2008 and 2014. The service sector stands in the centre of research, as the role of this sector is becoming more and more important. Whereas the importance of other sectors has decreased in the previous years and decades, the role of services shows an increasing trend in developed societies. The paper focuses on three factors. Firstly, I examine whether the classical theory is relevant, in which there is a negative linkage between profitability and capital leverage. Secondly, I examine the linkage between liquidity and capital leverage. Finally, I examine the principle of maturity matching, namely if firms in the service sector keep the golden rule to finance their non-current assets from non-current liabilities and equity.
THE EFFECT OF INVESTMENT OPPORTUNITY SET ON CORPORATE CAPITAL STURUCTURE

ABSTRACT Investment opportunity is the heart of the company's growth is that become important expectation which desired by the internal and external parties of company such as management, investors and creditors. The purpose of this study was to analyze the significance of the effect of IOS on the capital structure of the company. Object of this study is automotive and component companies and the research span was 2008-2012. The dependent variable of this study is the firm's capital structure, while the independent variable is IOS which consists of 5 single’s proxy. The data used are secondary data from ICMD 2008-2012. The analytical tool used is a simple regression and factor analysis. The results showed that IOS significantly positive effect on capital structure. There are three viable IOS proxy used to form the joint proxy variables IOS that is E / P , MV / BVA and MV / BE. This study confirms that the proxy IOS with combined proxy better than a single proxy . This study also supports the pecking order theory than trade off theory regarding the relationship between IOS corporate capital structure.