Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa).

INTRODUCTION Tumeric is a spice that comes from the root Curcuma longa, a member of the ginger family, Zingaberaceae. In Ayurveda (Indian traditional medicine), tumeric has been used for its medicinal properties for various indications and through different routes of administration, including topically, orally, and by inhalation. Curcuminoids are components of tumeric, which include mainly curcumin (diferuloyl methane), demethoxycurcumin, and bisdemethoxycurcmin. OBJECTIVES The goal of this systematic review of the literature was to summarize the literature on the safety and anti-inflammatory activity of curcumin. METHODS A search of the computerized database MEDLINE (1966 to January 2002), a manual search of bibliographies of papers identified through MEDLINE, and an Internet search using multiple search engines for references on this topic was conducted. The PDR for Herbal Medicines, and four textbooks on herbal medicine and their bibliographies were also searched. RESULTS A large number of studies on curcumin were identified. These included studies on the antioxidant, anti-inflammatory, antiviral, and antifungal properties of curcuminoids. Studies on the toxicity and anti-inflammatory properties of curcumin have included in vitro, animal, and human studies. A phase 1 human trial with 25 subjects using up to 8000 mg of curcumin per day for 3 months found no toxicity from curcumin. Five other human trials using 1125-2500 mg of curcumin per day have also found it to be safe. These human studies have found some evidence of anti-inflammatory activity of curcumin. The laboratory studies have identified a number of different molecules involved in inflammation that are inhibited by curcumin including phospholipase, lipooxygenase, cyclooxygenase 2, leukotrienes, thromboxane, prostaglandins, nitric oxide, collagenase, elastase, hyaluronidase, monocyte chemoattractant protein-1 (MCP-1), interferon-inducible protein, tumor necrosis factor (TNF), and interleukin-12 (IL-12). CONCLUSIONS Curcumin has been demonstrated to be safe in six human trials and has demonstrated anti-inflammatory activity. It may exert its anti-inflammatory activity by inhibition of a number of different molecules that play a role in inflammation.
ISO 9001 Implementation Barriers and Misconceptions: An Empirical Study

Despite the widespread use of ISO 9001 and the many certified organizations in the Arab countries, only five Iraqi organizations were ISO certified at the end of 2008. The purpose of this empirical study is to examine the various barriers and misconceptions that impede ISO 9001 implementation in the service and manufacturing sectors in Iraq. In order to identify these factors a structured survey was conducted using a random sample of 50 directors in service and manufacturing organizations in Baghdad. The analysis of the survey revealed nine important factors that hinder the implementation of the standards; lack of top management commitment heads the list. In addition, ten misconceptions were identified by this study, including the top ranked belief that ISO 9001 uncovers job security. The study suggested the need to formulate a national strategy to meet the emerging ISO requirements which will enable Iraqi organizations to achieve superior quality of goods and services. This study contributes to the body of knowledge in the area of quality management systems with particular interest on Iraq. The findings of this work are limited by the sample surveyed and the geographical limits, however, the findings reached carry many implications for policy- makers in Iraq.
Crowdsourcing's socio-space behavior on the economic agglomeration of accommodation in Bogotá: Case study locality of Teusaquillo

The objective of this study was to explore the agglomeration of hotels in Bogota with the purpose of calculating the degree of spatial concentration and the behavior of the economic offer of collaboration in the lodging industry, in order to identify patterns of impact of this in the sector. We used primary data from the locality of Teusaquillo related to crowdsourcing with the support of the geographical information system QGIS ®, which were contrasted with the characteristics of the hotels located in the Local Planning Units (UPZ) of the locality. The results allowed to conclude that the offer of accommodation by crowdsourcing affects the price of the hotel room, and tends to generate economic agglomerations based on the spatial concentration of the collaboration.
Splittings of non-finitely generated groups

In geometric group theory one uses group actions on spaces to gain information about groups. One natural space to use is the Cayley graph of a group. The Cayley graph arguments that one encounters tend to require local finiteness, and hence finite generation of the group. In this paper, I take the theory of intersections of splittings of finitely generated groups (as developed by Scott, Scott-Swarup, and Niblo-Sageev-Scott-Swarup), and rework it to remove finite generation assumptions. Whereas the aforementioned authors relied on the local finiteness of the Cayley graph, I capitalize on the Bass-Serre trees for the splittings.
Integrated financial trading system based on distributed in-memory database

The portion of HFT in market is growing rapidly. To process hundreds of thousands of orders per second which are requested by algorithms trading, not by humans, trading systems are required to equip high performance computer, network devices, and efficient software solutions. To achieve performance requirements, financial trading software processes data in memory with delayed writes to databases. However, these systems are getting closer to their physical limits and in most cases fault tolerance is ignored to improve the performance of the system. In this paper, we designed an integrated financial trading system which runs on a distributed manner based on in-memory NoSQL database and InfiniBand technologies.
The role of zooxanthellae in the thermal tolerance of corals: a ‘nugget of hope’ for coral reefs in an era of climate change

The ability of coral reefs to survive the projected increases in temperature due to global warming will depend largely on the ability of corals to adapt or acclimatize to increased temperature extremes over the next few decades. Many coral species are highly sensitive to temperature stress and the number of stress (bleaching) episodes has increased in recent decades. We investigated the acclimatization potential of Acropora millepora, a common and widespread Indo-Pacific hard coral species, through transplantation and experimental manipulation. We show that adult corals, at least in some circumstances, are capable of acquiring increased thermal tolerance and that the increased tolerance is a direct result of a change in the symbiont type dominating their tissues from Symbiodinium type C to D. Our data suggest that the change in symbiont type in our experiment was due to a shuffling of existing types already present in coral tissues, not through exogenous uptake from the environment. The level of increased tolerance gained by the corals changing their dominant symbiont type to D (the most thermally resistant type known) is around 1–1.5 °C. This is the first study to show that thermal acclimatization is causally related to symbiont type and provides new insight into the ecological advantage of corals harbouring mixed algal populations. While this increase is of huge ecological significance for many coral species, in the absence of other mechanisms of thermal acclimatization/adaptation, it may not be sufficient to survive climate change under predicted sea surface temperature scenarios over the next 100 years. However, it may be enough to ‘buy time’ while greenhouse reduction measures are put in place.
The efficacy of nefazodone augmentation for treatment‐resistant depression with anxiety symptoms or anxiety disorder

Depression that fails to respond to multiple antidepressant trials, particularly when accompanied by anxiety, constitutes a difficult treatment challenge. Those with anxious depression may be less likely to respond to treatment than their cohorts without anxiety. Anxiety symptoms also predict a higher rate of suicide, particularly if the symptoms do not improve early in the course of treatment. Eleven consenting outpatients with treatment‐resistant depression and/or comorbid anxiety disorders were treated with nefazodone, slowly added to their ongoing treatment regimens. Doses were initiated at 50 mg a day and slowly increased by 50 mg increments until an optimum response was achieved. The Clinical Global Impression of Improvement (CGI) Scale was employed to monitor the medication effects. In all 11 cases, nefazodone was efficacious and well tolerated in the treatment of both depressive and anxiety components. After nefazodone augmentation, the mean CGI score for combined depression and anxiety symptoms was (±sd) 1.52 (0.52) on a scale from 1 (very much better) to 7 (very much worse). Seven of the 11 cases achieved complete remission of depressive symptoms (χ2=11.55, P<.005) and 9 of the 11 cases, complete remission of anxiety symptoms (χ2=15.23, P<.0005). The mean effective dose for nefazodone (mean±sd) was 200.0 (34.2) mg a day (range 50–300 mg a day). Nefazodone's unique pharmacologic profile may explain its unusual efficacy in these cases of treatment‐resistant major depression. Depression and Anxiety 18:83–88, 2003. © 2003 Wiley‐Liss, Inc.
[The effect of valsartan and fluvastatin on the connective tissue growth factor expression in experimental diabetic cardiomyopathy].

OBJECTIVE To investigate the effect of valsartan and fluvastatin on the expression of connective tissue growth factor in early diabetic cardiomyopathy. METHODS Forty male SD rats were randomly divided into five groups: normal control group, diabetic model (DM) group, DM + valsartan group (30 mg x kg(-1) x d(-1)), DM + fluvastatin group (4 mg x kg(-1) x d(-1) ) and DM + valsartan + fluvastatin group (valsartan 30 mg x kg(-1) x d(-1) + fluvastatin 4 mg x kg(-1) x d(-1)). After 12 weeks, miniature cardiac catheter was inserted into the left ventricle to conduct hemodynamic examination. Then myocardial tissue was collected and collagen content was detected with Van-Gieson staining. The levels of connective tissue growth factor (CTGF) mRNA expression in myocardium were determined using RT-PCR and Western blot was used to detect the protein expression of transforming growth factor (TGF) beta, CTGF, collagen I and III. RESULTS By the end of the experiment, left ventricular diastolic function was significantly decreased in the DM group in comparison with the control group (P < 0.05). As compared with the normal control group, myocardial collagen content was significantly increased 1.1 fold (P < 0.05), and the heart weight/body weight ratio was increased 37% in the DM group, but it was significantly reduced in the valsartan group and the fluvastatin group in comparison with the DM group (both P < 0.05). The mRNA expression of CTGF was significantly higher in the DM group than in the control group, but it was significantly lower in the valsartan group and fluvastatin group than that in the DM group (both P < 0.05). The values of protein expression of CTGF, TGFbeta, collagen I and III were all significantly higher in the DM group than those in the control group (all P < 0.05). The protein expression of CTGF, TGFbeta, collagen I and III in the valsartan group and fluvastatin group was all significantly lower than that in the DM group (P < 0.05). It was shown that treatment with valsartan or fluvastatin was effective for myocardial fibrosis in diabetic SD rats and valsartan combined with fluvastatin would be still better. CONCLUSION Valsartan and fluvastatin can reduce myocardial fibrosis, resulting in prevention of left ventricular remodeling and improvement of cardiac function in an experimental model of diabetic cardiomyopathy. The process was related to the inhibition of the overexpression of CTGF and TGFbeta and reduction in cardiac extracellular matrix collagen content. It is also shown that a better result may be obtained with the coadministration of the two drugs than using one alone.
American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery Medical guidelines for clinical practice for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient.

n f b i a C s b 4 t American Association of Clinical Endocrinologists, The besity Society, and American Society for Metabolic & ariatric Surgery Medical Guidelines for Clinical Practice or the Perioperative Nutritional, Metabolic, and Nonsurgial Support of the Bariatric Surgery Patient. Mechanick JI, Kushner RF, Sugerman HJ, et al. Surg bes Relat Dis, 2008;4:S109–S184. Recommendation 68 (R66) states “Currently recomended prophylactic regimens include sequential compresion devices (Grade C; BEL 3), as well as subcutaneously dministered unfractionated heparin or low-moleculareight heparin for 3 days before and after bariatric surgery Grade B; BEL 2 [randomized]), . ” H
Significant association between the C(−1019)G functional polymorphism of the HTR1A gene and impulsivity

Serotonin‐1A (5‐HT1A) receptors are known to play a role in impulsivity‐related behavior. The C(−1019)G functional polymorphism (rs6295) has been suggested to regulate the 5‐HT1A receptor gene (HTR1A) expression in presynaptic raphe neurons, namely, increased receptor concentration and reduced neuronal firing could be associated with the G allele. Previous studies indicate that this polymorphism is associated with aggression, suicide, and several psychiatric disorders, yet its association with impulsivity has rarely been investigated. We studied the relationship between impulsivity and the C(−1019)G polymorphism of the HTR1A in a population sample of 725 volunteers using the Impulsiveness subscale (IVE‐I) of the Eysenck Impulsiveness, Venturesomeness, and Empathy scale and also the Barratt Impulsiveness Scale (BIS‐11). Data were analyzed using analysis of variance with age and gender as covariates and Tukey's HSD post‐hoc test. Post‐hoc analysis revealed that the study had 0.958 power to detect 0.15 effect size. Significant differences between the C(−1019)G genotype groups (GG vs. GC vs. CC) were found. Subjects carrying GG genotype showed significantly higher impulsiveness scores compared to GC or CC carriers for the IVE‐I scale (P = 0.014), for the Motor (P = 0.021), Cognitive Impulsiveness (P = 0.002), and for the BIS total score (P = 0.008) but not for the Nonplanning Impulsiveness (P = 0.520) subscale of the BIS‐11. Our results suggest the involvement of the HTR1A in the continuum phenotype of impulsivity. © 2009 Wiley‐Liss, Inc.
Clock Synchronization in Industrial Automation Networks - Comparison of Different Syntonization Methods

Synchronization of distributed clocks is a critical task in many real time applications over Ethernet. The Ethernet protocol, due to its non-deterministic nature, is not suitable for real-time applications with very strict synchronicity requirements. However, the limit is continuously being pushed outwards by current research. The Precision Time Protocol (PTP), delivered by the IEEE 1588 standard, provides high synchronization accuracy and has been adopted in many real time applications in the areas of industrial automation, measurement & control, communications etc. This paper will discuss several issues aimed at improving the synchronization performance.
Cell Cycle , Cell Death , and Senescence A Novel 19 q 13 Nucleolar Zinc Finger Protein Suppresses Tumor Cell Growth through Inhibiting Ribosome Biogenesis and Inducing Apoptosis but Is Frequently Silenced inMultiple Carcinomas

Epigenetic disruption of tumor suppressor genes is frequently involved in tumorigenesis. We identified a novel 19q13 KRAB domain-containing zinc finger protein, ZNF545/ZFP82, broadly expressed in normal tissues but downregulated in multiple tumor cell lines. The ZNF545 promoter contains a CpG island, which is frequently methylated in cell lines. The transcriptional silencing of ZNF545 could be reversed by pharmacologic or genetic demethylation, indicating direct epigenetic silencing. ZNF545 was also frequently methylated in multiple primary tumors of nasopharyngeal, esophageal, lung, gastric, colon, and breast, but rarely in normal epithelial tissues and paired normal tissues. ZNF545 is located in the nucleus and mainly sequestered in nucleoli, functioning as a repressor. ZNF545 is able to repress NF-kB and AP-1 signaling pathways, whereas ectopic expression of ZNF545 in silenced tumor cells significantly inhibited their growth and induced apoptosis. Functional studies showed that ZNF545 was involved in ribosome biogenesis through inhibiting the activity of rDNA promoter and decreasing cellular protein translation efficiency. Thus, we identified ZNF545 as a novel tumor suppressor inducing tumor cell apoptosis, repressing ribosome biogenesis and target gene transcription. The tumor-specific methylation of ZNF545 could be an epigenetic biomarker for cancer diagnosis. Mol Cancer Res; 10(7); 925–36. 2012 AACR.
Nucleoside triphosphatase and RNA helicase activities associated with GB virus B nonstructural protein 3.

GB virus B (GBV-B) is a positive-stranded RNA virus that belongs to the Flaviviridae family. This virus is closely related to hepatitis C virus (HCV) and causes acute hepatitis in tamarins (Saguinus species). Nonstructural protein 3 (NS3) of GBV-B contains sequence motifs predictive of three enzymatic activities: serine protease, nucleoside triphosphatase (NTPase), and RNA helicase. The N-terminal serine protease has been characterized and shown to share similar substrate specificity with the HCV NS3 protease. In this report, a full-length GBV-B NS3 protein was expressed in Escherichia coli and purified to homogeneity. This recombinant protein was shown to possess polynucleotide-stimulated NTPase and double-stranded RNA (dsRNA) unwinding activities. Both activities were abolished by a single amino acid substitution, from the Lys (K) residue in the conserved walker motif A (or Ia) "AXXXXGK(210)S" to an Ala (A), confirming that they are intrinsic to GBV-B NS3. Kinetic parameters (K(m) and k(cat)) for hydrolysis of various NTPs or dNTPs were obtained. The dsRNA unwinding activity depends on the presence of divalent metal ions and ATP and requires an RNA duplex substrate with 3' unpaired regions (RNAs with 5' unpaired regions only or with blunt ends are not suitable substrates for this enzyme). This indicates that GBV-B NS3 RNA helicase unwinds dsRNA in the 3' to 5' direction. Direct interaction of the GBV-B NS3 protein with a single-stranded RNA was established using a gel-based RNA bandshift assay. Finally, a homology model of GBV-B NS3 RNA helicase domain based on the 3-dimensional structure of the HCV NS3 helicase that shows a great similarity in overall structure and surface charge distribution between the two proteins was proposed.
Preliminary Experience with Carbon Dioxide Therapy In the Treatment of Pressure Ulcers In a Bedridden Elderly Patient

1. Fodor PA, Levin MJ, Weinberg A et al. Atypical herpes simplex virus encephalitis diagnosed by PCR amplification of viral DNA from CSF. Neurology 1998;51:554–559. 2. Whitley RJ, Cobbs CG, Alford CA Jr et al. Diseases that mimic herpes simplex encephalitis. Diagnosis, presentation, and outcome. NIAD Collaborative Antiviral Study Group. JAMA 1989;262:234–239. 3. Mook-Kanamori B, van de Beek D, Wijdicks EF. Herpes simplex encephalitis with normal initial cerebrospinal fluid examination. J Am Geriatr Soc 2009;57:1514–1515. 4. Riera-Mestre A, Gubieras L, Martinez-Yelamos S et al. Adult herpes simplex encephalitis: Fifteen years’ experience. Enferm Infecc Microbiol Clin 2009;27:143–147. 5. Schiff D, Rosenblum MK. Herpes simplex encephalitis (HSE) and the immunocompromised: A clinical and autopsy study of HSE in the settings of cancer and human immunodeficiency virus-type 1 infection. Hum Pathol 1998;29:215–222. 6. Kennedy PG, Chaudhuri A. Herpes simplex encephalitis. J Neurol Neurosurg Psychiatry 2002;73:237–238. 7. Studahl M, Bergstrom T, Hagberg L. Acute viral encephalitis in adults—A prospective study. Scand J Infect Dis 1998;30:215–220. 8. Weil AA, Glaser CA, Amad Z et al. Patients with suspected herpes simplex encephalitis: Rethinking an initial negative polymerase chain reaction result. Clin Infect Dis 2002;34:1154–1157.
Suicidal behavior in war veterans

Military veterans represent a unique, heterogeneous population with suicide prevalence rates, risk factors and preventative management needs that differ from those of the rest of community. Veterans worldwide receive high proportions of their healthcare from community providers, and sensitivity to these distinct needs is required for optimized care. An overview of the recent prevalence-study literature, with a focus upon statistical design, is presented in order to provide a critical orientation within this field with high levels of popular media attention. Attention to psychiatric comorbidity, subthreshold symptomology, select signature disorders of contemporary conflicts (namely, post-traumatic stress disorder and traumatic brain injury), and veteran life narratives before, within and beyond military service will guide our review of risk factor assessment and management strategies. This critical review of the literature provides an overview of this active field of neuropsychiatric research with a select focus upon these topics of special interest.
Treatment of upper gastrointestinal fistula and leakage with personal stage nutrition support.

AIM To investigate the feasibility of treatment for upper gastrointestinal fistula and leakage with personal stage nutrition support. METHODS Forty-three patients with upper gastrointestinal fistula and leakage were randomly divided into two groups. Patients in group A were treated with personal stage nutrition support and patients in group B were treated with total parental nutrition (TPN) in combination with operation. Nutritional states of the candidates were evaluated by detecting albumin (Alb) and pre-Alb. The balance between nutrition and hepatic function was evaluated by measurement of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (Tbill) before and after operation. At the same time their complications and hospitalized time were surveyed. RESULTS Personal stage nutrition support improved upper gastrointestinal fistula and leakage. The nutrition state and hepatic function were better in patients who received personal stage nutrition support than in those who did not receive TPN. There was no significant difference in the complication and hospitalized time in the two groups of patients. CONCLUSION Upper gastrointestinal fistula and leakage can be treated with personal stage nutrition support which is more beneficial for the post-operation recovery and more economic than surgical operation.
A high quality vertical transition between GCPW and SMCPW lines in multilayer technology

A high quality vertical transition from DC up to 20 GHz between GCPW and SMCPW lines is presented. In order to design this transition a circuit model has been developed. This model is directly extracted from the geometry of the transition using closed expressions and gives unprecedented insight into the sensitivity of the design to its different constitutive elements. Thus, it provides an easy way to find suitable initial dimensions for the transition in a circuit simulator, thereby greatly reducing the effort spent in subsequent electromagnetic simulations. A comparison between circuit and electromagnetic simulations shows very good agreement in the analyzed situation. Careful measurements were taken on a fabricated transition with a back-to-back configuration showing a return loss greater than 20 dB for all ranges considered.