Miracle-dz/UniFAR-FTUs huggingface dataset:
Vestibular function and curative effect of BPPV patients in different duration by application of electronystagmography and posturography.

Objects: Benign paroxysmal positional vertigo (BPPV) is a common peripheral vestibular disease clinically. Electronystagmography (ENG) and posturography are commonly used methods for diagnosis of BPPV and examination of the vestibular function. Sparse study reported the characteristics of nystagmus and vestibular function and the curative effect in different duration of BPPV patients. Methods: This is a retrospective study of 40 adults with vestibular symptoms. Before ENG test and posturography test, the subjects underwent physical examination and excluded central disorders. The canalith repositioning maneuver was used for the therapy of BPPV and the curative effect was studied between different duration groups. Results: Of patients who suffered BPPV, higher rates of abnormal ENG were observed in the longer duration of BPPV. Among patients of BPPV, the patients’ vestibular function in more than 12 months duration was inferior to the patients of a shorter duration. Moreover, the curative effect by repositioning maneuver in the shorter duration was superior to the longer duration. Conclusions: The present study suggested that the vestibular function in patients that suffered BPPV deteriorates as the course of BPPV develops. The curative effect by repositioning maneuver in the patients of shorter duration is more satisfied than the longer duration.
The Application of a Time Series Forecasting Model in Air Passenger Volume Prediction Research

This paper presents a new forecasting model of time series (NFMTS). NFMTS is a set of time series forecasting models. In forecasting air passenger volume in Chengdu from 1993 to 2001, take point A (0.0002,0.8,0.0002) as the starting point of calculation, by calculating and screening, the automatic optimization search method of NFMTS can be applied to screen the optimal time series prediction model in NFMTS as Ju (0.00002,0.8,0.00002). It can not only make the predicted value of Chengdu's air passenger volume reach MSE=0 and AFER=0, but also can predict the future air passenger volume of Chengdu from 2002 to 2003. The prediction model presented in this paper is simple in calculation and easy to use. In dealing with the air passenger volume of Chengdu from 1993 to 2003. It has advantages over traditional grey model, grey neural network model and grey support vector machine model.
The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch

PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) is a tumor suppressor that directly dephosphorylates a wide array of substrates, most notably the prosurvival kinase Akt. However, little is known about the molecular mechanisms governing PHLPP1 itself. ABSTRACT PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) is a tumor suppressor that directly dephosphorylates a wide array of substrates, most notably the prosurvival kinase Akt. However, little is known about the molecular mechanisms governing PHLPP1 itself. Here, we report that PHLPP1 is dynamically regulated in a cell cycle-dependent manner and deletion of PHLPP1 results in mitotic delays and increased rates of chromosomal segregation errors. We show that PHLPP1 is hyperphosphorylated during mitosis by Cdk1 in a functionally uncharacterized region known as the PHLPP1 N-terminal extension (NTE). A proximity-dependent biotin identification (BioID) interaction screen revealed that during mitosis, PHLPP1 dissociates from plasma membrane scaffolds, such as Scribble, by a mechanism that depends on its NTE and gains proximity to kinetochore and mitotic spindle proteins such as KNL1 and TPX2. Our data are consistent with a model in which phosphorylation of PHLPP1 during mitosis regulates binding to its mitotic partners and allows accurate progression through mitosis. The finding that PHLPP1 binds mitotic proteins in a cell cycle- and phosphorylation-dependent manner may have relevance to its tumor-suppressive function.
The new therapeutic options in the treatment of rheumatoid arthritis

Sažetak Reumatoidni artitis (RA) kronična je, upalna, autoimuna bolest od koje boluje približno 1% svjetske populacije. Složena mreža citokina odgovorna je za pokretanje i održavanje upalnih zbivanja u reumatoidnom artritisu. Ovaj pregled prikazuje najnovija saznanja o terapiji reumatoidnog artritisa lijekovima usmjerenim prema tumor-necrosis factor-alpha (TNF-alfa), inhibitorima interleukin-1, te lijekovima usmjerenim prema stanicama T i B poput abatacepta i rituksimaba.
Effects of Dielectric Monopolar Radiofrequency with Vacuumtherapy in the Treatment of Chronic Constipation in Patients with Intellectual Developmental Disorders

Aim Chronic constipation is a high prevalence complication in patients with intellectual developmental disorders due to medication intake and physical activity reduction. Several manual therapy techniques have achieved good results at its treatment, being these a considerable option as no adverse effects have been shown. Nevertheless, the use of electrotherapy devices has not been studied on chronic constipation treatment. These may be considered as a potential tool which may supplement treatment. Thermotherapy by dielectric monopolar radiofrequency (DMR) linked to vacuum therapy could activate local blood irrigation at the colon level and peristaltic movements due to mechanic push-pull. The aim of this study is therefore to prove the efficacy of DMR linked to vacuum therapy for the treatment of chronic constipation in intellectual developmental disorders patients. Methods Nineteen patients which met the inclusion criteria were chosen. Number of stools and shape of them (Bristol Stool Questionnaire) were measured in a period of 14 days, when patients received their common care techniques for chronic constipation. After that, patients received 14 days of DMR linked to vacuum therapy treatment. The same variables were measured in the meantime so as to observe possible differences. Results DMR linked to vacuum therapy proved an improvement in number of stools per day and the shape/quality of them. No adverse results were observed. Conclusion DMR linked to vacuum treatment seems effective for the treatment of chronic constipation in intellectual developmental disorders patients.
Attitudes, understanding and compliance with cervical cancer screening in Eastern European migrants to England

Introduction: The incidence of cervical cancer in England, in the 25-34 year old age group is rising but screening coverage is falling. It has been hypothesised that this might be in part due to the effect of migration of Eastern European (EE) women to England. This thesis explores the attitudes, understanding and behaviours of migrant EE women in England towards cervical cancer prevention strategies, focusing on the effect of migration. Further to assess cervical cancer prevention as an entirety the understandings and attitudes of EE adolescents and healthcare professionals in England have been investigated. Methods: Five studies, using a combination of qualitative, quantitative and systematic review research methodologies were conducted to assess the aims. The studies were conducted in England and Latvia. Results: Comparison of the English and Latvian studies revealed that both the native Latvian women and migrant EE women had lower levels of understanding of the process of cervical screening than the native English women. The largest influence on cervical screening behaviours both prior to and after migration was the women’s overall perception of the healthcare system. The migrant EE women held negative attitudes towards the healthcare system in England. Minimal changes occurred in attitudes and behaviours towards cervical screening after migration. Practice nurse smear takers in England were found to lack adequate awareness of current cervical screening protocols or HPV vaccination and not all were confident in providing HPV related patient education. Awareness of primary prevention of cervical cancer in the Latvian adolescent population was suboptimal, although they appeared to be partaking in high-risk behaviours. Conclusions: The uptake of cervical cancer prevention modalities in the migrant EE population appears to be influenced by their pre-existing knowledge of cervical screening and cervical cancer and their perception of the healthcare system and healthcare professionals in England.
Application of the Visualization through Stereoscopic Glasses in the Massage Therapy

T massage therapy can be examined as a tool for restoration, activation and recreation. This therapy has a wide application in sport. The development of the massage techniques is implemented in two directions: east and west. According to many studies, both directions have a positive effect on the human life [1-9]. Eastern massage therapy is based on the impact on biologically active points and energy meridians [1,4-6,9]. The Western massage therapy uses massage techniques to influence the lymph system [2,3,7,8]. The massage therapy is defined as older than recorded time. The rubbing is considered as the primary form of medicine until the pharmaceutical revolution of the 1940s. Popularized again as part of the alternative medicine movement, massage therapy has recently received empirical support for facilitating growth, reducing pain, increasing alertness, diminishing depression, and enhancing immune function [2]. This study combines several issues in regard to massage therapy, sports and technological development. First, the literature review confirms that the massage therapy has extensive application as rehabilitation means for eliminating painful symptoms, for increasing the range of motion [1,4,10-14] and in sports performance [4,11,15-19]. Second, the technological development in recent years, allows exResearch Article Exercise Medicine Open Access eISSN: 2508-9056
Reusable objects

• Introduction to Reusable Objects, page 2 • The Object Manager, page 4 • Network Objects, page 11 • Port Objects, page 13 • Tunnel Zones, page 17 • Application Filters, page 17 • VLAN Tag Objects, page 17 • Security Group Tag Objects, page 18 • URL Objects, page 19 • Geolocation Objects, page 20 • Variable Sets, page 21 • Security Intelligence Lists and Feeds, page 38 • Sinkhole Objects, page 47 • File Lists, page 48 • Cipher Suite Lists, page 54 • Distinguished Name Objects, page 55 • PKI Objects, page 57 • SLA Monitor Objects, page 73 • Prefix Lists, page 74 • Route Maps, page 76 • Access List, page 79 • AS Path Objects, page 82 • Community Lists, page 83
Global Market Integration and Central Political Control: Foreign Trade and Intergovernmental Relations in China

Prevailing economic theories predict that world market integration unleashes centrifugal forces from within and undermines domestic central political authority. Reversing the conventional bottom-up, demand-side approach, this article highlights the incentives of national-level political actors. It suggests that when institutionally empowered vis-à-vis the subnational units, the center will seek to enhance political control over regions thriving in the global market to extract revenues, remedy interregional disparity, and maintain central rule. Through analyzing pooled cross-sectional, time-series data for Chinese provinces during 1978 to 2002, it shows that the Chinese political center has manipulated its personnel monopoly power within the ruling Communist Party to exert a tighter grip over provincial party secretaries, the top officials in the provinces more exposed to the international market. Furthermore, provinces overseen by more controlled party secretaries actually received less favorable terms during fiscal contracting, implying their greater revenue submission to the center.
Survey of gram negative and gram positive bacteria in drinking water supplies in Karachi, Pakistan.

More than 20,000 children die annually in the city of Karachi alone, majority of whose death are thought to be associated with waterborne pathogens. Drinking water and recreational exposure to polluted water pose a significant public health threat including gastroenteritis, paralysis, meningitis, hepatitis, respiratory illness and diarrhoea. The aim of this study was to determine the presence of bacterial contamination in drinking water supplies in Karachi, Pakistan. A total of fifty two domestic tap water samples were collected from different areas of Karachi, between May to June 2011 and analyzed for bacterial presence based on biochemical testing. The results revealed a high prevalence of Bacillus spp. (86.84%), followed by Pseudomonas spp. (57.14%), Citrobacter spp. (14.28%) Serratia spp. , Enterobacteriaceae species (14.28%), Corneybacterium (10.52%), and Acinetobacter spp. (2.63%). These findings disclose bacterial contamination in drinking water supplies, many of which are pathogenic and can produce serious as well as life-threatening infections. Future studies will determine whether bacterial contamination of drinking water occurred post-source contamination. It is recommended that household water treatment interventions should be introduced to improve water quality.
Managing for rainfall variability: impacts of grazing strategies on perennial grass dynamics in a dry tropical savanna

Rainfall variability remains a major challenge to sustainable grazing management in northern Australia with perennial grasses the key to the stability of the resources that maintain a sustainable grazing industry. This paper describes the dynamics of five perennial grasses – Bothriochloa ewartiana (Domin) C.E. Hubb. , Chrysopogon fallax S.T. Blake, Aristida spp. , Panicum effusum R. Br. and Heteropogon contortus (L.) P. Beauv. ex Roem. & Schult. in relation to three grazing strategies – moderate stocking at long-term carrying capacity, heavy stocking and rotational wet season spelling. The research was conducted in permanent quadrats on the predominant land type in an extensive grazing study in an Aristida-Bothriochloa pasture in north Australia between 1998 and 2010. Summer rainfall was above average for two periods – 1998 – 2001 and 2008 – 2010 with drought and below-average rainfall from 2002 to 2007. Low rainfall affected the dynamics of all grasses by reducing survival and basal area through its effect on plant size; this impact was most noticeable for the shorter-lived Aristida spp. , P. effusum and H. contortus. The impact of grazing was greatest on the long-lived B. ewartiana and C. fallax; this effect was accentuated by the 2002–07 drought. Heavy grazing during this period further reduced the survival and size of B. ewartiana in comparison with the moderate stocking and rotational spell treatments. In contrast, the survival of C. fallax was reduced in the moderate stocking and rotational spelling treatment during drought, relative to that under heavy grazing. The density of B. ewartiana declined even under moderate grazing and despite two sequences of above-average rainfall because seedling recruitment failed to offset mature plant death. Results from this study emphasised the importance of maintaining the existing populations of key long-lived species such as B. ewartiana through good management. These results also supported the overall findings from the grazing study indicating that stocking at the long-term carrying capacity is sustainable in managing for climate variability.
Effects of boron starvation on boron compartmentation, and possibly hormone-mediated elongation growth and apical dominance of pea (Pisum sativum) plants

Two experiments were carried out to study the effects of boron (B) deficiency on 7-day-old pea plants for 6 or 9 days under controlled growth chamber conditions. Growth and apical dominance (AD) of the plants and their B concentration and compartmentation were followed throughout the starvation period. Additionally, auxin (indoleacetic acid, IAA) concentration in the shoot apex and polar transport from it were measured along with the cytokinin (CK) concentration in the shoot apex and the roots. The results demonstrate that during a 6-day B-deficiency period, B concentration in the water-insoluble residue of the roots was very stable and could not easily be reduced. In contrast, B concentration in the cell sap fraction was very sensitive to external B supply. Twelve hours after transferring the plants from B-sufficient to B-deficient solutions, the B concentration in root cell sap declined to half the concentration of the control plants. In addition, B concentration in the new aerial plant parts, which developed after the onset of the B-deficiency treatment, was extremely low. A decline in elongation growth could be observed as soon as about 4 days after the imposition of B deficiency. This preceded the first measurable growth of lateral buds (release from AD). Before the onset of these morphological changes, there was a considerable decline in CK concentration, accompanied by a dramatic decrease in IAA export out of the shoot apex, a decline in IAA concentration in the shoot apex and the roots and a reduced capacity for polar IAA-transport. These changes are discussed as possible reasons for the observed reduction in elongation growth and AD. These hormonal changes themselves are possibly the result of the decreased symplasmic B concentration, which in turn may be responsible for the reduced concentration in apical CKs. A sequence of events, which may be causally related, is suggested to explain the effects of B deficiency on the growth and AD of pea plants.
Feel Good or Do Good? A Valence–Function Framework for Understanding Emotions

Previous thinking has often categorized emotions as either pleasant or unpleasant or examined to what extent they are functional or dysfunctional. We suggest that researchers should consider the positivity or negativity of discrete emotions on both dimensions: subjective feelings and constructiveness of outcomes. We discuss how, across contexts, a specific emotion can potentially be categorized differently within the framework. We further suggest that this approach is particularly useful in unique, complex contexts that involve clashes among goals, interests, or values, such as violent intergroup conflicts. Using this context, we demonstrate how emotions that feel good to people can lead to behaviors and attitudes that sustain violence and thwart conflict resolution, whereas emotions that promote conflict resolution are often unpleasant. Such clashes may depend on the presence of embedded contextual factors, such as group membership and relative power. Thus, this framework will be useful for examining specific emotions while taking contextual factors into consideration. Finally, we examine several important questions stemming from our framework and suggest directions for future research.
The economic burden of cancers attributable to smoking in Korea, 2014

INTRODUCTION Associations between smoking, cancer and mortality are well established. Although cancer mortality rates have decreased in recent years, the economic burden of smoking-related cancers continues to increase. This study investigates the economic costs of cancers related to smoking in Korea in 2014. METHODS Cancer patients were identified through National Health Insurance Services medical claims with ICD-10 cancer codes. We multiplied the costs by the population attributable fraction for each type of cancer and calculated direct and indirect costs, where direct costs comprise direct medical and non-medical costs of inpatients and outpatients, and indirect costs include estimates of future income loss due to premature death, productivity loss during hospitalization and outpatient visits, and job loss. RESULTS In 2014, there were 79297 smoking-related cancer patients, accounting for 8.47% of all Korean cancer cases for that year. The direct cost of cancers due to smoking was approximately 595 million USD, whereas indirect costs were much higher, at nearly 2.2 billion USD. The average expenditure of a typical patient was 34815 USD. Lung, liver and stomach cancers were most prevalent and represented the most significant share of the economic burden, whereas the largest per-patient spending was for pancreatic, liver, and lung cancers. Lung, liver and stomach cancers had the highest economic impact on men, while lung, liver and ovarian cancers had the most significant economic impact on women. CONCLUSIONS It is imperative that more stringent steps be taken to reduce the huge economic burden of cancers linked to smoking. ABBREVIATIONS IARC: International Agency for Research on Cancer, PAF: population attributable fraction, NHIS: National Health Insurance Services, ICD-10: International Statistical Classification of Diseases and Related Health Problem 10th Revision, GDP: Gross Domestic Product, DALYs: Disability-Adjusted-Life-Years, WHO: World Health Organization, FCTC: Framework Convention on Tobacco Control.
Body Shape, Reproductive Effort, and Relative Clutch Mass in Lizards: Resolution of a Paradox

Lizard body shapes, selected for in the context of predator escape and foraging, serve well to predict the ratios of clutch to body (termed "relative clutch mass") whether in weights or calories. Species cryptic in behavior that employ the sit-and-wait foraging strategy exhibit high relative clutch mass (RCM) whereas species using flight for escape and the wide-foraging strategy exhibit low RCM. The RCM values for other species with more complex predator escape strategies are predictable once unique aspects of their ecologies are considered. It is concluded that RCM in lizards need not be correlated to reproductive effort, and, if it is, then reproductive effort coevolved with predator escape and foraging strategies and ecologically analogous species should not only exhibit similar RCM values, but also similar reproductive efforts.
The relationship between fatty liver disease and liver metastases from colorectal cancer

Objective To evaluate the relationship between fatty liver disease and liver metastases from colorectal cancer.Methods Eight hundred and ninety patients with colorectal cancer,who were submitted to hospital from 1993 to 2002 and had complete clinical data,were retrospectively analyzed.Of 890 patients,127 were diagnosed as fatty liver(FL)by ultrasonography,and the other 763 who were without fatty liver were served as controls(NFL). The clinical data including pathology,liver matastasis or mortality after surgery were analyzed.The survival rate and liver matastasis after surgery were followed up and statistically analyzed.Results The liver metastases was lower in FL group than that in NFL group(7 cases vs 102 cases,P=0.012). The tumor size was smaller in FL group than that in NFL group[(4.15±1.80)crn vs(4.77±2.25)cm,P=0.0016]. The Dukes B(247/732,33.74%)and C(232/732,31.83%)patients were more common in NFL group,whereas Dukes A(41/121,33.61 %)and B(40/121,32.77%)were more common in FL group with significant difference(P＜0.05). No significant difference was found in 7-year survival rate between two groups who had been followed up(P=0.3024). Conclusion The lower incidence of liver metastases is found in FL group,which indicate that fatty liver disease may inhibit liver metastases from colorectal cancer by underlying mechanisms. Key words: Fatty liver; Colorectal neoplasms; Neoplasm metastasis