Miracle-dz/UniFAR-FTUs huggingface dataset:
Protein kinase C and lipid signaling for sustained cellular responses

Since the second messenger role was proposed for the products of inositol phospholipid hydrolysis, considerable progress has been made in our understanding of the biochemical mechanism of the intracellular signaling network. It is now becoming evident that stimulation of a cell surface receptor initiates a degradation cascade of various membrane lipid constituents. Many of their metabolites have potentials to induce, intensify, and prolong the activation of protein kinase C that is needed for sustained cellular responses. —Nishizuka, Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9, 484–496 (1995)
Herbal medicines for the treatment of osteoarthritis: a systematic review.

OBJECTIVE Limitations in the conventional medical management of osteoarthritis indicate a real need for safe and effective treatment of osteoarthritis patients. Herbal medicines may provide a solution to this problem. The aim of this article was to review systematically all randomized controlled trials on the effectiveness of herbal medicines in the treatment of osteoarthritis. METHODS Computerized literature searches were carried out on five electronic databases. Trial data were extracted in a standardized, predefined manner and assessed independently. RESULTS Twelve trials and two systematic reviews fulfilled the inclusion criteria. The authors found promising evidence for the effective use of some herbal preparations in the treatment of osteoarthritis. In addition, evidence suggesting that some herbal preparations reduce consumption of non-steroidal anti-inflammatory drugs was found. The reviewed herbal medicines appear relatively safe. CONCLUSIONS Some herbal medicines may offer a much-needed alternative for patients with osteoarthritis.
Methane output and lactation response in Holstein cattle with monensin or unsaturated fat added to the diet.

We measured effects of continuous vs twice-daily feeding, the addition of unsaturated fat to the diet, and monensin on milk production, milk composition, feed intake, and CO2-methane production in four experiments in a herd of 88 to 109 milking Holsteins. Methane and CO2 production increased with twice-daily feeding, but the CO2:CH4 ratio remained unchanged. Soybean oil did not affect the milkfat percentages, but fatty acid composition was changed. All saturated fatty acids up to and including 16:0 decreased (P < .01), whereas 18:0 and trans 18:1 increased (P < .001). The 18:2 conjugated dienes also increased (P < .01) when the cows were fed soybean oil. Monensin addition to the diet at 24 ppm decreased methane production (P < .01); the CO2:CH4 ratios reached 15, milk production increased (P < .01), and milkfat percentage and total milkfat output decreased (P < .01), as did feed consumption, compared with cows fed diets without monensin (P < .05). Milk fatty acid composition showed evidence of depressed ruminal biohydrogenation: saturated fatty acids (P < .05) decreased and 18:1 increased (P < .001); most of the increase was seen in the trans 18:1 isomer. As with soybean oil feeding, addition of monensin also increased (P < .05) the concentration of conjugated dienes. The monensin feeding trial was repeated 161 d later with 88 cows, of which 67 received monensin in the diet in the first trial and 21 cows were newly freshened and had never received monensin. Methane production again decreased (P < .05), but this time the CO2:CH4 ratio did not change and all other monensin-related effects were absent. The ruminal microflora in the cows that had previously received monensin seemed to have undergone some adaptive changes and no longer responded as before.
Food as a source for QS inhibitors : Iberin from Horseradish 1 Revealed as a Quorum Sensing Inhibitor of Pseudomonas aeruginosa 2 3

22 Foods with health promoting effects beyond nutritional values have been gaining 23 increasing research focus in recent years, although not much has been published on 24 this subject in relation to bacterial infections. With respect to treatment, a novel 25 Copyright © 2012, American Society for Microbiology. All Rights Reserved. Appl. Environ. Microbiol. doi:10.1128/AEM.05992-11 AEM Accepts, published online ahead of print on 27 January 2012 on Jne 9, 2017 by gest ht://aem . sm . rg/ D ow nladed fom
Influenza-Like Illness Among University Students: Symptom Severity and Duration Due to Influenza Virus Infection Compared to Other Etiologies

Abstract Objective: University students with influenza-like illness (ILI) were assessed to determine whether symptom severity, duration, or missed days of school or work varied according to etiology. Participants: Sixty persons presenting to a university health clinic with ILI symptoms during 3 consecutive influenza seasons completed baseline survey and viral testing; 51 (85%) completed follow-up. Methods: Influenza viral culture and polymerase chain reaction and respiratory virus immunofluorescence assay testing were performed. Information collected at baseline and follow-up included symptom occurrence, severity, duration, and numbers of days of work and school missed. Results: Influenza virus was confirmed in 63% of participants. Influenza-positive individuals were no more likely to report any symptom or miss more days of school or work. Self-reported severity and durations of symptoms were similar between groups. Conclusions: Students with influenza-associated ILI were similar to those with noninfluenza ILI with respect to severity, duration, and numbers of days of school and work missed.
Disruption of HSP90 Function Reverts Tumor Necrosis Factor-induced Necrosis to Apoptosis*

Triggering tumor necrosis factor receptor-1 (TNFR1) induces apoptosis in various cell lines. In contrast, stimulation of TNFR1 in L929sA leads to necrosis. Inhibition of HSP90, a chaperone for many kinases, by geldanamycin or radicicol shifted the response of L929sA cells to TNF from necrosis to apoptosis. This shift was blocked by CrmA but not by BCL-2 overexpression, suggesting that it occurred through activation of procaspase-8. Geldanamycin pretreatment led to a proteasome-dependent decrease in the levels of several TNFR1-interacting proteins including the kinases receptor-interacting protein, inhibitor of κB kinase-α, inhibitor of κB kinase-β, and to a lesser extent the adaptors NF-κB essential modulator and tumor necrosis factor receptor-associated factor 2. As a consequence, NF-κB, p38MAPK, and JNK activation were abolished. No significant decrease in the levels of mitogen-activated protein kinases, adaptor proteins TNFR-associated death domain and Fas-associated death domain, or caspase-3, -8, and -9 could be detected. These results suggest that HSP90 client proteins play a crucial role in necrotic signaling. We conclude that inhibition of HSP90 may alter the composition of the TNFR1 complex, favoring the caspase-8-dependent apoptotic pathway. In the absence of geldanamycin, certain HSP90 client proteins may be preferentially recruited to the TNFR1 complex, promoting necrosis. Thus, the availability of proteins such as receptor-interacting protein, Fas-associated death domain, and caspase-8 can determine whether TNFR1 activation will lead to apoptosis or to necrosis.
Collective transportation of objects by a swarm of robots

A collective transport strategy, inspired by the food retrieval procedure of ant colonies, has been implemented on a swarm of robots that are smaller than the object. A simple odometry-based team coordination strategy in combination with an omni-directional camera has been implemented, resulting in a well-coordinated e ort by the robots without using any communication. The strategy is fully decentralized. Moreover, a simple recruitment process has been introduced but it did not improve the transportation eciency. The transportation strategy consists of four stages, namely prey discovery, team coordination, recruitment, and transportation. A simulation environment capable of handling robot swarms and their physical interaction is developed for this project. Using robots weighing 3 kg, a 3 kg object was successfully transported in 48 out of 50 trials, whereas a 4.5 kg object was successfully transportedin 44 out of 50 trials.
The LRP5 High-Bone-Mass G171V Mutation Disrupts LRP5 Interaction with Mesd

ABSTRACT The mechanism by which the high-bone-mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates canonical Wnt signaling was investigated. The mutation was previously shown to reduce DKK1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for DKK-mediated antagonism. However, we found that the third YWTD repeat, but not the first repeat domain, is required for DKK1-mediated antagonism. Instead, we found that the G171V mutation disrupted the interaction of LRP5 with Mesd, a chaperone protein for LRP5/6 that is required for transport of the coreceptors to cell surfaces, resulting in fewer LRP5 molecules on the cell surface. Although the reduction in the number of cell surface LRP5 molecules led to a reduction in Wnt signaling in a paracrine paradigm, the mutation did not appear to affect the activity of coexpressed Wnt in an autocrine paradigm. Together with the observation that osteoblast cells produce autocrine canonical Wnt, Wnt7b, and that osteocytes produce paracrine DKK1, we think that the G171V mutation may cause an increase in Wnt activity in osteoblasts by reducing the number of targets for paracrine DKK1 to antagonize without affecting the activity of autocrine Wnt.
The Design , Implementation and Usability of a Tool for Real Time Visualization of Information in Global Networks

A visualization tool was created for Ericsson Research to be used for real time visualization of information in global networks. The design and implementation was done using an iterative user centered design process. The usability of the visualization tool was evaluated using user testing. The visualization tool VI is a tool for visualizing real time data in global networks. One or several servers that collect the data from the network supply the visualization tool with a stream of live data. The visualization tool is configured using an XML-based API where the user specifies how the data will be interpreted, what the network topology looks like and where in the world nodes are located. VI can represent data in nodes with bars and histograms and nodes can be colored based on the data as well. Information in the links can be tied to the color and width/thickness of the links. It is possible to both suppress and highlight a subset of the data. The visualization tool takes abstract network data and ties this to a geographical representation. The geographical representation makes it easier for the users to communicate about what they see in the interface and make the navigation of the interface more intuitive. A usability evaluation was conducted to determine what usability issues the visualization tool had, how it could be improved and to learn more about the users and how they interact with the tool. The usability tests show that the users are able to draw accurate conclusions about the data and scenarios used in the usability tests by using the visualization tool in various ways to compare different sets of data. Users do this by mapping different data sets to different views or by toggling between different data sets. It is difficult for the users to envision how a graphical user interface using 3D-graphics and plenty of interaction will look like if all they have are some paper sketches to look at. Stop motion animation can be a cost efficient tool that may make it easier for the interaction designer to communicate to the users his vision of what the final design will look like.
Effect of dexmedetomidine added to spinal bupivacaine for urological procedures.

OBJECTIVES To determine the effect of adding dexmedetomidine to bupivacaine for neuraxial anesthesia. METHODS Sixty-six patients were studied between April and May 2008 in the University of Jordan, Amman Jordan. They were randomly assigned into 3 groups, each receiving spinal bupivacaine 12.5mg combined with normal saline (group N) Dexmedetomidine 5 microg (group D5), or dexmedetomidine 10 microg (group D10). The onset times to reach T10 sensory and Bromage 3 motor block, and the regression times to reach S1 sensory level and Bromage 0 motor scale, were recorded. RESULTS The mean time of sensory block to reach the T10 dermatome was 4.7 +/- 2.0 minutes in D10 group, 6.3 +/- 2.7 minutes in D5, and 9.5 +/- 3.0 minutes in group N. The mean time to reach Bromage 3 scale was 10.4 +/- 3.4 minutes in group D10, 13.0+/-3.4 minutes in D5, and 18.0 +/- 3.3 minutes in group N. The regression time to reach S1 dermatome was 338.9 +/- 44.8 minutes in group D10, 277.1 +/- 23.2 minutes in D5, and 165.5 +/- 32.9 minutes in group N. The regression to Bromage 0 was 302.9 +/- 36.7 minutes in D10, 246.4 +/- 25.7 minutes in D5, and 140.1 +/- 32.3 minutes in group N. Onset and regression of sensory and motor block were highly significant (N vesus D5, N versus D10, and D5 versus D10, p<0.001). CONCLUSION Dexmedetomidine has a dose dependant effect on the onset and regression of sensory and motor block when used as an adjuvant to bupivacaine in spinal anesthesia.
Is invasion success explained by the enemy release hypothesis

A recent trend in invasion ecology relates the success of non-indigenous species (NIS) to reduced control by enemies such as pathogens, parasites and predators (i.e. the enemy release hypothesis, ERH). Despite the demonstrated importance of enemies to host population dynamics, studies of the ERH are split – biogeographical analyses primarily show a reduction in the diversity of enemies in the introduced range compared with the native range, while community studies imply that NIS are no less affected by enemies than native species in the invaded community. A broad review of the invasion literature implies at least eight non-exclusive explanations for this enigma. In addition, we argue that the ERH has often been accepted uncritically wherever (i) NIS often appear larger, more fecund, or somehow ‘better’ than either congeners in the introduced region, or conspecifics in the native range; and (ii) known enemies are conspicuously absent from the introduced range. However, all NIS, regardless of their abundance or impact, will lose natural enemies at a biogeographical scale. Given the complexity of processes that underlie biological invasions, we argue against a simple relationship between enemy ‘release’ and the vigour, abundance or impact of NIS.
Lung metabolism during ventilator-induced lung injury: stretching the relevance of the normally aerated lung*.

Concerns about pulmonary complications of positive pressure ventilation (1) are at least as old as the description of the Acute Respiratory Distress Syndrome (ARDS) (2). Yet, it took about a decade until experimental findings (3) shifted the focus from air leaks and oxygen toxicity to the biological effects of large excursions of the lung parenchyma (4). The demonstration that mechanical ventilation with high peak inspiratory pressures and low positive end-expiratory pressure (PEEP) could produce edema, increased alveolo-capillary permeability, leukocyte infiltration, and inflammation in normal lungs established the current understanding of ventilator-induced lung injury (VILI) (4, 5). The clinical relevance of VILI was confirmed by the demonstration of a 22% decrease in mortality of ARDS patients when lung stretch was reduced through lower tidal volumes (VT). (6). In addition to excessive lung stretch due to large VT, it has been recognized that VILI can also be caused by low end-expiratory lung volumes, even at low airway pressures. Mechanisms proposed to explain such injury include concentration of stresses in the heterogeneously expanding lung parenchyma (7), and propagation and rupture of liquid plugs producing injurious fluid mechanical stresses during cyclic recruitment-derecruitment of distal lung units (8, 9). Mitigation of these low-volume phenomena by optimizing lung recruitment with higher PEEP levels (10) and proning (11) has been beneficial in patients with moderate and severe ARDS. However, despite the large number of experimental and clinical studies, uncertainty persists about the relative contribution of overdistension versus low-volume injury to the ultimate lung damage produced by VILI (12). Topographically, in supine patients, nondependent (ventral) injury would be expected if overdistension would predominate (13), whereas dependent (dorsal) damage would be expected for predominant low-volume injury (14). The clinical relevance of the topic has been emphasized by the suggestion that the mass of opening-closing lung is an independent risk factor for death in patients with ARDS (15), and that regional forces during mechanical ventilation determine lung parenchyma abnormalities found in ARDS survivors (16).
Counting of deep-level traps using a charge-coupled device

Quantization in dark current generation has been observed for the first time through the use of a virtual-phase charge-coupled device. Two sites for bulk silicon dark current have been identified with capture cross sections of 1.8 × 10<sup>-15</sup>cm<sup>2</sup>and 5.4 × 10<sup>-16</sup>cm<sup>2</sup>, and concentrations of 1.3 × 10<sup>9</sup>cm<sup>-3</sup>and 1.5 × 10<sup>8</sup>cm<sup>-3</sup>, respectively.
Intramammary infections in heifers during early lactation following intramammary infusion of pirlimycin hydrochloride or penicillin-novobiocin at the first milking after parturition

A study was conducted to determine whether intramammary antibiotic treatment of heifer mammary glands following the first milking after calving was effective for reducing the percentage of mammary quarters infected during early lactation. Jersey and Holstein heifers from two research herds were assigned to one of three treatment groups: (1) no intramammary infusion following the first milking after parturition, (2) intramammary infusion of all quarters with pirlimycin hydrochloride following the first milking after parturition and (3) intramammary infusion of all quarters with novobiocin sodium plus penicillin G procaine following the first milking after parturition. Almost 93% of Jersey heifers (40/43) and 73·1% of quarters (125/171) were infected at the first milking. Almost 77% of quarters (33/43) were cured following treatment with pirlimycin, 61·8% (21/34) were cured following treatment with penicillin-novobiocin and 39·6% (19/48) of infections were eliminated spontaneously in the untreated control group. Significantly fewer infections were observed in pirlimycin or penicillin-novobiocin treated mammary glands of Jersey heifers during early lactation than in untreated control mammary glands. Almost 89% of Holstein heifers (32/36) and 52·8% of quarters (76/144) were infected at the first milking. About 57% (12/21) of quarters were cured following treatment with pirlimycin, 41·4% (12/29) were cured following treatment with penicillin-novobiocin and 23·1% (6/26) of infections were eliminated spontaneously in the untreated negative control group. Significantly fewer infections were observed in pirlimycin treated mammary glands of Holstein heifers during early lactation than in untreated control mammary glands. However, no significant differences were observed following penicillin-novobiocin treatment of Holstein heifers after the first milking of lactation compared with untreated control quarters. Coagulase-negative staphylococci, Streptococcus uberis and Streptococcus dysgalactiae subsp dysgalactiae were isolated most frequently in heifers from both herds.
Is it in the eyes? Dissociating the role of emotion and perceptual features of emotionally expressive faces in modulating orienting to eye gaze

This study investigated the role of the eye region of emotional facial expressions in modulating gaze orienting effects. Eye widening is characteristic of fearful and surprised expressions and may significantly increase the salience of perceived gaze direction. This perceptual bias rather than the emotional valence of certain expressions may drive enhanced gaze orienting effects. In a series of three experiments involving low anxiety participants, different emotional expressions were tested using a gaze-cueing paradigm. Fearful and surprised expressions enhanced the gaze orienting effect compared with happy or angry expressions. Presenting only the eye regions as cueing stimuli eliminated this effect whereas inversion globally reduced it. Both inversion and the use of eyes only attenuated the emotional valence of stimuli without affecting the perceptual salience of the eyes. The findings thus suggest that low-level stimulus features alone are not sufficient to drive gaze orienting modulations by emotion. Rather, they interact with the emotional valence of the expression that appears critical. The study supports the view that rapid processing of fearful and surprised emotional expressions can potentiate orienting to another person's averted gaze in non-anxious people.
Control-theoretic analysis of exploitation and exploration of the PSO algorithm

The behavior of the particle swarm optimization (PSO) algorithm is analyzed by regarding its dynamics as a system with multiplicative noise and applying control-theoretic analysis methods. In order to evaluate the convergence and diversity of the PSO algorithm, two measures related to the decay rate and l2 gain of the PSO dynamics are used. These measures are characterized by linear matrix inequalities (LMIs) and are therefore efficiently computed by convex optimization tools. As for the measure related to the decay rate, moreover, an alternative condition in terms of nonlinear scalar inequalities is presented which can be checked more shortly and accurately than the LMI. Numerical experiments suggest that the measures are effective enough to evaluate the convergence and diversity of the PSO algorithm, which results in better understanding of the PSO algorithm from the viewpoints of exploitation and exploration abilities.
Polyarthritis due to systemic lupus erythematosus in a dog

A five year old male mongrel dog was presented for medical consultation with a history of arthralgia. Complete blood count revealed linfopenia and neutropenia, antinuclear antibody was positive at 1:1,256, and synovial fluid analysis showed inflammatory arthritis with lupus erythematosus cells. No significant proteinuria was detected on urinalysis, and microalbuminuria measurement was performed to determine glomerulonephritis in early stage. Based on clinical signs, synovial fluid analysis, antinuclear antibody test and complete blood count, the diagnosis was systemic lupus erythematosus. The measurement of microalbuminuria was useful to demonstrate the absence of glomerulonephritis, and the performance of complementary tests proved to be indispensable for diagnosis and prognosis. Glucocorticoid treatment led to complete remission.