Miracle-dz/UniFAR-FTUs huggingface dataset:
Fully porous 3D printed titanium femoral stem to reduce stress‐shielding following total hip arthroplasty

Current hip replacement femoral implants are made of fully solid materials which all have stiffness considerably higher than that of bone. This mechanical mismatch can cause significant bone resorption secondary to stress shielding, which can lead to serious complications such as peri‐prosthetic fracture during or after revision surgery. In this work, a high strength fully porous material with tunable mechanical properties is introduced for use in hip replacement design. The implant macro geometry is based off of a short stem taper‐wedge implant compatible with minimally invasive hip replacement surgery. The implant micro‐architecture is fine‐tuned to locally mimic bone tissue properties which results in minimum bone resorption secondary to stress shielding. We present a systematic approach for the design of a 3D printed fully porous hip implant that encompasses the whole activity spectrum of implant development, from concept generation, multiscale mechanics of porous materials, material architecture tailoring, to additive manufacturing, and performance assessment via in vitro experiments in composite femurs. We show that the fully porous implant with an optimized material micro‐structure can reduce the amount of bone loss secondary to stress shielding by 75% compared to a fully solid implant. This result also agrees with those of the in vitro quasi‐physiological experimental model and the corresponding finite element model for both the optimized fully porous and fully solid implant. These studies demonstrate the merit and the potential of tuning material architecture to achieve a substantial reduction of bone resorption secondary to stress shielding. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1774–1783, 2017.
Evaluation of Estrogenic Receptors in the Nasal Mucosa of Women Taking Oral Contraceptives

Objective: Evaluate the influence of oral contraceptives on the distribution and concentration of estrogenic receptors in nasal mucosa. Method: Two groups of 32 women with regular menstrual cycles who had undergone nasal surgery were selected. One group of women was taking oral contraceptives, and the other wasn’t. Samples of mucosa of inferior nasal turbinate were analyzed by immunohistochemical staining for alpha and beta estrogen receptors. Results: The use of oral contraceptives induced a decrease of beta-receptor in lamina propria cells. On the other locations there was no statistically significant difference. In both groups there was a predominance of beta-receptor presence. Conclusion: Women taking contraceptive pills had a decrease of beta-receptor in lamina propria cells.
Crystal Structure of the Receptor-Binding Domain from Newly Emerged Middle East Respiratory Syndrome Coronavirus

ABSTRACT The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) has infected at least 77 people, with a fatality rate of more than 50%. Alarmingly, the virus demonstrates the capability of human-to-human transmission, raising the possibility of global spread and endangering world health and economy. Here we have identified the receptor-binding domain (RBD) from the MERS-CoV spike protein and determined its crystal structure. This study also presents a structural comparison of MERS-CoV RBD with other coronavirus RBDs, successfully positioning MERS-CoV on the landscape of coronavirus evolution and providing insights into receptor binding by MERS-CoV. Furthermore, we found that MERS-CoV RBD functions as an effective entry inhibitor of MERS-CoV. The identified MERS-CoV RBD may also serve as a potential candidate for MERS-CoV subunit vaccines. Overall, this study enhances our understanding of the evolution of coronavirus RBDs, provides insights into receptor recognition by MERS-CoV, and may help control the transmission of MERS-CoV in humans.
An update of safety of clinically used atypical antipsychotics

ABSTRACT Introduction: The atypical antipsychotic (APs) drugs have become the most widely used agents to treat a variety of psychoses because of their superiority with regard to safety and tolerability profile compared to conventional/‘typical’ APs. Areas covered: We aimed at providing a synthesis of most current evidence about the safety and tolerability profile of the most clinically used atypical APs so far marketed. Qualitative synthesis followed an electronic search made inquiring of the following databases: MEDLINE, Embase, PsycINFO and the Cochrane Library from inception until January 2016, combining free terms and MESH headings for the topics of psychiatric disorders and all atypical APs as following: ((safety OR adverse events OR side effects) AND (aripiprazole OR asenapine OR quetiapine OR olanzapine OR risperidone OR paliperidone OR ziprasidone OR lurasidone OR clozapine OR amisulpride OR iloperidone)). Expert opinion: A critical issue in the treatment with atypical APs is represented by their metabolic side effect profile (e.g. weight gain, lipid and glycaemic imbalance, risk of diabetes mellitus and diabetic ketoacidosis) which may limit their use in particular clinical samples. Electrolyte imbalance, ECG abnormalities and cardiovascular adverse effects may recommend a careful baseline and periodic assessments.
Observation of Crabtree Effect and Diauxic Behaviour of Yeast Using Absoption

Please cite this article as: Al-mhanna M. N. M (2010), Observation of Crabtree effect and diauxic behaviour of yeast by using absorption, Chemical Engineering Transactions, 21, 1465-1470 DOI: 10.3303/CET1021245 Observation of Crabtree Effect and Diauxic Behaviour of Yeast by Using Absorption Najah M. Mohammed Al-mhanna Institute of Bioprocess Engineering (BVT), Department of Chemical and Bioengineering, College of Engineering, University of Erlangen-Nurnberg Paul-Gordan-Strasse 3, 91052 Erlangen, Germany najah.mohammed@bvt.cbi. uni-erlangen.de
Systematically convergent basis sets with relativistic pseudopotentials. II. Small-core pseudopotentials and correlation consistent basis sets for the post-d group 16–18 elements

A series of correlation consistent basis sets have been developed for the post-d group 16–18 elements in conjunction with small-core relativistic pseudopotentials of the energy-consistent variety. The latter were adjusted to multiconfiguration Dirac–Hartree–Fock data based on the Dirac–Coulomb–Breit Hamiltonian. The outer-core (n−1)spd shells are explicitly treated together with the nsp valence shell with these PPs. The accompanying cc-pVnZ-PP and aug-cc-pVnZ-PP basis sets range in size from DZ to 5Z quality and yield systematic convergence of both Hartree–Fock and correlated total energies. In addition to the calculation of atomic electron affinities and dipole polarizabilities of the rare gas atoms, numerous molecular benchmark calculations (HBr, HI, HAt, Br2, I2, At2, SiSe, SiTe, SiPo, KrH+, XeH+, and RnH+) are also reported at the coupled cluster level of theory. For the purposes of comparison, all-electron calculations using the Douglas–Kroll–Hess Hamiltonian have also been carried out for the haloge.
Evaluation of the temperature stability of AlGaN/GaN heterostructure FETs

Temperature stress experiments up to 800/spl deg/C have been applied to AlGaN/GaN FET's grown by MOVPE on sapphire and their individual technological building blocks. It was found that the temperature limit is given by the irreversible degradation of the intrinsic active heterostructure material itself during operation above 600/spl deg/C. The irreversible degradation was observed for both unconnected and electrically operated devices during temperature stress.
Molecular Pathways: Understanding and Targeting Mutant Spliceosomal Proteins

Splicing of precursor messenger RNA is a critical step in regulating gene expression, and major advances are being made in understanding the composition and structure of the enzymatic complex that performs splicing, which is termed the “spliceosome. ” In parallel, there has been increased appreciation for diverse mechanisms by which alterations in splicing contribute to cancer pathogenesis. Key among these include change-of-function mutations in genes encoding spliceosomal proteins. Such mutations are among the most common genetic alterations in myeloid and lymphoid leukemias, making efforts to therapeutically target cells bearing these mutations critical. To this end, recent studies have clarified that pharmacologic modulation of splicing may be preferentially lethal for cells bearing spliceosomal mutations and may also have a role in the therapy of MYC-driven cancers. This has culminated in the initiation of a clinical trial of a novel oral spliceosome modulatory compound targeting the SF3B complex, and several novel alternative approaches to target splicing are in development as reviewed here. There is now, therefore, a great need to understand the mechanistic basis of altered spliceosomal function in cancers and to study the effects of spliceosomal modulatory compounds in preclinical settings and in well-designed clinical trials. Clin Cancer Res; 23(2); 336–41. ©2016 AACR.
Long term course of childhood epilepsy following relapse after antiepileptic drug withdrawal

Objective: To explore the course of epilepsy following relapse after antiepileptic drug (AED) withdrawal. Methods: Forty two patients were identified with onset of epilepsy in childhood in whom AEDs had been withdrawn after at least 2 years of seizure freedom, and in whom a relapse had occurred. Two patients were lost to follow up. Results: Median follow up after AED withdrawal was 5.9 years (range 1.6–13.2 years). Relapse occurred in more than half of the patients within 6 months of AED withdrawal. At the end of follow up, 12 patients (30%) were seizure free for at least 1 year (mean 10.4 years) without medication; 16 (40%) were seizure free for at least 1 year (mean 5.3 years) with ongoing medication; and 12 patients (30%) were seizure free for less than 1 year with medication. No status epilepticus occurred in any patient after withdrawal. Age at onset, if over the age of 5, combined with normal intelligence were predictive of an excellent outcome; presence of a neurological disorder, and hence symptomatic aetiology, was predictive of poor outcome after a relapse. Conclusions: Fears that premature withdrawal of AEDs might result in uncontrollable seizures were unsubstantiated in this study. The current practice of withdrawing AEDs in children who have been seizure free for 2 years can be benificial to most of these patients.
A Robust Parameter Design of Wide Band DGS Filter for Common-Mode Noise Mitigation in High-Speed Electronics

A defected ground structure (DGS), working as common-mode noise filter, is developed for high-speed electronic circuits. However, due to deviations of parameters inevitably exiting in the process and materials, the performance of the filter may shift and deteriorate even if the design is optimized. Therefore, a robust design method is proposed by using design of experiment and Taguchi method. Recognizing the deviations as uncontrollable factors and categorizing the prevailing and nonprevailing design parameters in the study, the filtering performance of common-mode DGS filter is not only optimized effectively with a wider stop band of 7.926 GHz but also highly resistive to the variations of design parameters.
Mirror therapy for patients with severe arm paresis after stroke – a randomized controlled trial

Objective: To evaluate the effects of individual or group mirror therapy on sensorimotor function, activities of daily living, quality of life and visuospatial neglect in patients with a severe arm paresis after stroke. Design: Randomized controlled trial. Setting: Inpatient rehabilitation centre. Subject: Sixty patients with a severe paresis of the arm within three months after stroke. Interventions: Three groups: (1) individual mirror therapy, (2) group mirror therapy and (3) control intervention with restricted view on the affected arm. Main measures: Motor function on impairment (Fugl-Meyer Test) and activity level (Action Research Arm Test), independence in activities of daily living (Barthel Index), quality of life (Stroke Impact Scale) and visuospatial neglect (Star Cancellation Test). Results: After five weeks, no significant group differences for motor function were found (P > 0.05). Pre–post differences for the Action Research Arm Test and Fugl-Meyer Test: individual mirror therapy: 3.4 (7.1) and 3.2 (3.8), group mirror therapy: 1.1 (3.1) and 5.1 (10.0) and control therapy: 2.8 (6.7) and 5.2 (8.7). However, a significant effect on visuospatial neglect for patients in the individual mirror therapy compared to control group could be shown (P < 0.01). Furthermore, it was possible to integrate a mirror therapy group intervention for severely affected patients after stroke. Conclusion: This study showed no effect on sensorimotor function of the arm, activities of daily living and quality of life of mirror therapy compared to a control intervention after stroke. However, a positive effect on visuospatial neglect was indicated.
Association of the Mediterranean dietary pattern with the incidence of depression: the Seguimiento Universidad de Navarra/University of Navarra follow-up (SUN) cohort.

CONTEXT Adherence to the Mediterranean dietary pattern (MDP) is thought to reduce inflammatory, vascular, and metabolic processes that may be involved in the risk of clinical depression. OBJECTIVE To assess the association between adherence to the MDP and the incidence of clinical depression. DESIGN Prospective study that uses a validated 136-item food frequency questionnaire to assess adherence to the MDP. The MDP score positively weighted the consumption of vegetables, fruit and nuts, cereal, legumes, and fish; the monounsaturated- to saturated-fatty-acids ratio; and moderate alcohol consumption, whereas meat or meat products and whole-fat dairy were negatively weighted. SETTING A dynamic cohort of university graduates (Seguimiento Universidad de Navarra/University of Navarra Follow-up [SUN] Project). PARTICIPANTS A total of 10 094 initially healthy Spanish participants from the SUN Project participated in the study. Recruitment began on December 21, 1999, and is ongoing. MAIN OUTCOME MEASURE Participants were classified as having incident depression if they were free of depression and antidepressant medication at baseline and reported a physician-made diagnosis of clinical depression and/or antidepressant medication use during follow-up. RESULTS After a median follow-up of 4.4 years, 480 new cases of depression were identified. The multiple adjusted hazard ratios (95% confidence intervals) of depression for the 4 upper successive categories of adherence to the MDP (taking the category of lowest adherence as reference) were 0.74 (0.57-0.98), 0.66 (0.50-0.86), 0.49 (0.36-0.67), and 0.58 (0.44-0.77) (P for trend <.001). Inverse dose-response relationships were found for fruit and nuts, the monounsaturated- to saturated-fatty-acids ratio, and legumes. CONCLUSIONS Our results suggest a potential protective role of the MDP with regard to the prevention of depressive disorders; additional longitudinal studies and trials are needed to confirm these findings.
Einführung in die Computerlinguistik

nouns: -> byesoa 'unit (of measure)' -> byeka 'group' We will adopt the convention of using the "natural" derivations for general use, unless the nature of the substance/location/item is known or must be emphasized. For example, we will use "byetaw" rather than "byepe" for the generic term meaning 'location', 'place', 'spot', etc. [ Table of
Insuficiencia venosa. Prevención y tratamiento

El aumento del sedentarismo en la sociedad occidental, la alta esperanza de vida, la obesidad y el ortostatismo prolongado hacen que las enfermedades venosas registren una gran incidencia en la actualidad. Las enfermedades venosas afectan a entre el 10 y el 40% de la población adulta, sobre todo en las extremidades inferiores, según los últimos estudios. La insuficiencia venosa crónica afecta al 50% de la población que tiene más de 50 años. A continuación se describe a grandes rasgos el sistema venoso del cuerpo humano.
The Process-Knowledge Model of Health Literacy: Evidence from a Componential Analysis of Two Commonly Used Measures

We investigated the effects of domain-general processing capacity (fluid ability such as working memory), domain-general knowledge (crystallized ability such as vocabulary), and domain-specific health knowledge for two of the most commonly used measures of health literacy (S-TOFHLA and REALM). One hundred forty six community-dwelling older adults participated; 103 had been diagnosed with hypertension. The results showed that older adults who had higher levels of processing capacity or knowledge (domain-general or health) performed better on both of the health literacy measures. Processing capacity interacted with knowledge: Processing capacity had a lower level of association with health literacy for participants with more knowledge than for those with lower levels of knowledge, suggesting that knowledge may offset the effects of processing capacity limitations on health literacy. Furthermore, performance on the two health literacy measures appeared to reflect a different weighting for the three types of abilities. S-TOFHLA performance reflected processing capacity as well as general knowledge, whereas performance on the REALM depended more on general and health knowledge than on processing capacity. The findings support a process-knowledge model of health literacy among older adults, and have implications for selecting health literacy measures in various health care contexts.
The Oppenheim effect in scholarly journal publishing

Purpose – This paper aims to look at the Oppenheim effect in scholarly journal publishing.Design/methodology/approach – Discusses the quality control of refereed scholarly journals.Findings – A key finding of this research was that editors perceived originality to be the most important factor in their assessment of manuscripts.Originality/value – Provides a discussion on the quality control of scholarly journals.
Secrecy capacity of wiretap channel for a new scenario and designing code for wiretap channel

The concept of information theoretic security is introduced. Secrecy capacity of two receiver broadcast channel for a new scenario is derived in which it is assumed that the legitimate receiver has access to a noisy version of eavesdroppers channel outputs. Also the ideas of code designing to achieve zero error on main channel and perfect secrecy on the eavesdropper's channel, without invoking complicated capacity achieving codes are provided.
Adequacy of Synthetic Diets for Reproduction of Swine

Summary Two sows which consumed synthetic diets and were given injections of approximately 400 μg each of vit. B12 reared their first litters. The weights of the pigs when weaned at 8 weeks were subnormal, 20 and 26 lbs. , and there were other signs of mild nutritional deficiency. One of the sows received by injection 2,380 μg of the vitamin during a second gestation and lactation and reared a litter of 7 pigs with the unusual average weaning weight of 47 lbs. The other sow consumed during her second gestation and lactation a diet that contained a water extract of liver and weaned a litter of 7 with an average weight of 35 lbs. The inclusion of a liver extract in the synthetic diet was not more effective than was the injection of vit. B12 and the evidence indicates that swine can complete a normal life cycle on diets that contain no unrecognized nutrients.
Induction of Mitogen-activated Protein Kinase Phosphatase-1 by Arachidonic Acid in Vascular Smooth Muscle Cells*

Arachidonic acid (AA) and its metabolites play important roles in a variety of biological processes, such as signal transduction, contraction, chemotaxis, and cell proliferation and differentiation. It was demonstrated recently that AA can activate mitogen-activated protein kinases (MAPKs), which are crucial for transducing signals initiating cell growth and apoptosis. Here we studied the effect of AA on the induction of MAPK phosphatase-1 (MKP-1) in vascular smooth muscle cells (VSMCs) and found that AA stimulated induction of MKP-1 mRNA and proteins in VSMCs in a time- and dose-dependent manner. Specific inhibitors of cyclooxygenase-, lipoxygenase-, and cytochrome P450-dependent metabolism did not affect AA-induced MKP-1 expression, indicating that eicosanoid biosynthesis was not involved in this process. The glutathione precursor N-acetylcysteine, an antioxidant, abolished AA-stimulated MKP-1 gene expression, whereas inhibition of protein kinase C by calphostin C had no influence on MKP-1 induction. VSMC pretreatment with genistein, a tyrosine kinase inhibitor, completely blocked AA-stimulated MKP-1 induction. MAPK kinase inhibitor PD 98059 did abolish AA-stimulated activation of extracellular signal-regulated kinases but not MKP-1 induction. Furthermore, agonists that increase AA release stimulated MKP-1 induction and activation of MAPKs, including extracellular signal-regulated kinases and c-Jun NH2-terminal protein kinases or stress-activated protein kinases. Taken together, our findings demonstrate that AA induced MKP-1 expression in VSMCs via activation of tyrosine kinases involving AA-induced free radical generation, suggesting an important role for MKP-1 in the regulation of AA-initiated signal transduction in VSMCs.
Overlapping Communities Detection Based on Link Partition in Directed Networks

Many complex systems can be described as networks to comprehend both the structure and the function. Community structure is one of the most important properties of complex networks. Detecting overlapping communities in networks have been more attention in recent years, but the most of approaches to this problem have been applied to the undirected networks. This paper presents a novel approach based on link partition to detect overlapping communities structure in directed networks. In contrast to previous researches focused on grouping nodes, our algorithm defines communities as groups of directed links rather than nodes with the purpose of nodes naturally belong to more than one community. This approach can identify a suitable number of overlapping communities without any prior knowledge about the community in directed networks. We evaluate our algorithm on a simple artificial network and several real-networks. Experimental results demonstrate that the algorithm proposed is efficient for detecting overlapping communities in directed networks. DOI: http://dx.doi. org/10.11591/telkomnika.v11i9. 3304
Alagille syndrome

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