Miracle-dz/UniFAR-FTUs huggingface dataset:
Immune Responses Intranasal Immunization Promotes Th17

Th17 cells are a lineage of CD4 (cid:1) T cells characterized by IL-17 secretion, which plays a crucial role in immune responses against important respiratory pathogens, such as Mycobacterium tuberculosis . In this study, we demonstrated that intranasal (i.n.) immunization leads per se to Th17-biased immune responses, regardless of the adjuvant used. The activated CD4 (cid:1) T cells also showed an up-regulated expression of the chemokine receptor CCR6, which is a marker for murine Th17 cells. These results have important implications in the context of optimizing rational vaccine design, since i.n. immunization appears to be the strategy of choice for situations where the induction of a Th17 phenotype would be beneﬁcial. The Journal of Immunology, 2009, 183: 6933–6938.
The Missing Doublet Model Revamped

We revisit the Missing Doublet Model (MDM) as a means to address the apparent difficulties of the minimal SU(5) supergravity model in dealing with the doublet-triplet splitting problem, the prediction of α3(MZ), and the proton lifetime. We revamp the original MDM by extending its observable sector to include fields and interactions that naturally suppress the dimension-five proton decay operators and that allow see-saw neutrino masses. We also endow the model with a hidden sector which (via gaugino condensation) triggers supersymmetry breaking of the desired magnitude, and (via hidden matter condensation) yields a new dynamical intermediate scale for the right-handed neutrino masses (∼ 1010 GeV), and provides an effective Higgs mixing parameter μ. The model is consistent with gauge coupling unification for experimentally acceptable values of α3(MZ), and with proton decay limits even for large values of tan β. The right-handed neutrinos can be produced subsequent to inflation, and their out-of-equilibrium decays induce a lepton asymmetry which is later reprocessed (via sphaleron interactions) into a baryon asymmetry at the electroweak scale. The resulting see-saw neutrino masses provide a candidate for the hot dark matter component of the Universe (mντ ∼ O(10 eV)) and are consistent with the MSW solution to the solar neutrino problem. We finally compare the features of this traditional GUT model with that of the readily string-derivable SU(5)×U(1) model, and discuss the prospects of deriving the revamped MDM from string theory. CTP-TAMU-29/95 ACT-11/95 August 1995 † Address after August 15, 1995: Department of Physics, Rice University, Houston, TX 77005, USA.
HELCOM core indicator report-Population trends and abundance of seals

This core indicator evaluates the status of the marine environment based on population trends and abundance of the three species of seals that occur in the Baltic Sea. Good status is achieved for each species when i) the abundance of seals in each management unit is has attained a Limit Reference Level (LRL) of at least 10,000 individuals to ensure long-term viability and ii) the species-specific growth rate is achieved indicating that abundance is not affected by severe anthropogenic pressures.
COMP BIOCHEM PHYSIOL 113A; 2: 113-119, 1996

The fatty acid composition of the Ruditapes decussatus spat fed on three different microalgal diets during 4 weeks was determined. The fatty acid pattern of each diet was also analysed. The diets used were Isochrysis galbana, clone T-ISO, Tetraselmis suecica, and Phaeodactylum tricornutum. The fatty acid composition of the spat was usually well correlated with that of the diet supplied. Major differences among spat cultures were found in 14:0, 16:0, 16:1n-9, 16:1n-7, 18:1n-9, 18:2n-6, 18:3n-3, 18:4n-3, 20:5n-3, 22:5n-6 and 22:6n-3 fatty acids. These differences were correlated with the particular fatty acid content of each diet supplied. It has been shown that R. decussatus spat have a very low capacity to elongate and desaturate linolenic acid to n-3 PUFA, so when 20:5n-3 or 22:6n-3 were not present in the diet, they were also absent, at least in measurable amounts, in the clams. The absence of any of the “essential” fatty acids, 20:5n-3 in T-IS0 or 22:6n-3 in Tetraselmis, did not limit spat growth, so their role as “essential” fatty acids might be a matter for discussion. Finally, the nutritive value of each diet was discussed in terms of its fatty acid composition.
Educational Program to Improve Care for the Lesbian, Gay, Bisexual and Transgender (LGBT) Patient

The focus of this capstone project is to explore the impact of registered nurses’ bias and lack of knowledge associated with the care of the LGBT patient. A Quasiexperimental design was used to evaluate the cause-and-effect relationship of an educational intervention. This intervention provided LGBT cultural knowledge and provides evidence regarding how homophobia and transphobia among nurses creates and perpetuates disparities among LGBT people. Attitude and knowledge assessment tools were used to collect responses from participant’s pre and post intervention. Using parametric and descriptive statistics, the participants’ data were analyzed. There were no statistically significant differences between the pre and post intervention scores. Although statistical significance was lacking, clinical significance was inferred by the participants’ knowledge gap in their posed questions at the conclusion of the educational intervention. The implementation of similar training sessions, offered in a recurring fashion, will likely be necessary to effectively decrease the healthcare disparities currently being experienced by the LGBT population.
Fall Prevention in Older Adults Who Reside in Nursing Homes

Falls among older adults who reside in the nursing home setting are a major problem in the United States (Center for Disease Control and Prevention [CDC], 2015). The site of this project was a nursing home located in a small town in New Hampshire. This home had a problem with the number of falls that occurred on a monthly basis. The rate of falls on average was two falls per month. This project sought to reduce the number of falls to zero over the course of three months. A fall revention program using evidence base interventions was developed to reach this objective. The interventions included staff education, medication reviews, an exercise program and hourly rounding. However, the fall rate at the completion of this project increased to four falls per month. This increase can be attributed to the lack of staff buy in to the program and insufficient staffing numbers. Even though the results demonstrated an increase in the rate of falls it is important to note that there was only one fall related injury during this time. The remainder of falls did not result in injury. Falls can have considerable consequences for the health status, autonomy and the quality of life of a nursing home resident involved in a fall (CDC, 2015).
CMAR_A_204472 7933..7951

Pengliang Xin Wenqian Xu Xiongpeng Zhu Chuntuan Li Yan Zheng Tingjin Zheng Wenzhao Cheng Qunyi Peng 1Department of Haematology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, People’s Republic of China; 2Central Laboratory, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, People’s Republic of China; 3Stem Cell Translational Research Center, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, People’s Republic of China Purpose: To investigate the effects of BEZ235 on chronic myeloid leukemia (CML) cells. Methods: MTS assay was used to detect the proliferation of CML cells. The proteins expression were detected by Western blot assay. The effects of BEZ235 on autophagy in CML cells were verified through transmission electron microscopy and evaluated by laser confocal microscopy. Annexin V-FITC/PI double staining flow cytometry was used to detect apoptosis. A xenograft model was established to observe the therapeutic effect of BEZ235 in vivo. Results: BEZ235 could inhibit the proliferation of CML cells; CQ and 3-MA could increase the proliferation inhibition and Z-VAD-FMK can reduce the proliferation inhibition of BEZ235 on CML cells (P<0.05). Results of TEM showed that the autophagosomes of CML cells treated with BEZ235 increased (P<0.05). The results by confocal microscopy showed that the autophagic activity of K562 cells increased with BEZ235 treatment. When BEZ235 combined with CQ, BEZ235-induced autophagic flow was blocked. FCM results showed that BEZ235 could induces apoptosis in CML cells. Z-VAD-FMK could decrease the apoptosis of CML cells induced by BEZ235. CQ increased the apoptosis of CML cells induced by BEZ235 (P<0.05). Western blot showed that BEZ235 inhibited the phosphorylation of AKT and S6K. BEZ235 alone could upregulate the expression of cleaved caspase-3 and LC3II. When combined with Z-VAD-FMK, the expression of cleaved caspase-3 was lower than that of BEZ235 alone. When combined with CQ, the expression of cleaved caspase-3 and LC3II were higher than those of BEZ235 alone (P<0.05). BEZ235 could inhibit the growth of xenografts of CML cell line. Conclusion: BEZ235 can inhibit the proliferation of CML cells, induce apoptosis, and enhance autophagy activity. It induces protective autophagy. The combination of CQ can enhance the apoptosis and proliferation inhibition of CML cells induced by BEZ235.
Face Recognition based Attendance Monitoring System

— This paper is proposed the face recognition method using PCA with neural network back error propagation learning algorithm . In this paper a feature is extracted using principal component analysis and then classification by creation of back propagation neural network. We run our algorithm for face recognition application using principal component analysis, neural network and also calculate its performance by using the photometric normalization technique: Histogram Equalization and comparing with Euclidean Distance, and Normalized correlation classifiers. The system produces promising results for face verification and face recognition. Demonstrate the recognition accuracy for given number of input pattern.
Board Governance and Managerial Short-term Incentives

This paper examines the relationship between board independence degree and managerial short-term incentives in investment decisions using a game-theoretical framework which is based on the model of Narayanan (1985). Because the model here connects corporate governance by a board and investment decisions by a manager, we can see clearly how the board affects the manager's investment decisions using its wage policy for the manager. According to the results here, although corporate governance by the board can alleviate managerial short-term incentives in investment decisions, it can not solve these kinds of biases completely. Therefore, to accomplish our final target of eliminating managerial short-term incentives in investment decisions, the only way we can do is to make the information between board and manager completely symmetric. In the comparative statics analysis here, we also know that board independence degree may also change as firms' characteristics change when manager has a certain short-term incentive. Therefore, sometimes a board with lower independence degree would also be appropriate.
ASSESSMENT OF SIZE BASED ORAL TOXICITY OF SILVER NANOPARTICLES ON SERUM LIPID PROFILE, LIVER AND KIDNEY FUNCTION OF MALE WISTAR RATS

Nanotechnology has received unprecedented growth and height which has revolutionized the consumer products, medical and industrial applications, thereby making it more compact, feasible and appropriate. But uncurbed use of nanoparticles and nanomaterials has led to its release into the environment and its exposure to human beings. Present study aimed to quest the repercussion of PVP coated silver nanoparticles (20 nm and 40 nm) administered orally at a dose level 1 and 2 mg/kgb.wt. /day for 45 days on male albino rat. On 46 day body weight was measured and autopsies were performed to collect serum for anaylsis. Organ like liver and kidney were used for histopathologic examination. Group recevied high dose showed highly significant decline. Liver weight was found to be affected. The mild to severe alteration in serum profile was obtained indicating liver damage whereas kidney damage was clear from blood urea and creatinine level in serum. These results were supported by histopathology observations of liver and kidney. Thus it can be concluded from data that the oral administration of AgNPs (20 nm and 40 nm) drive to hepatic and renal toxicity in experimental groups at such a low dose under in vivo condition. Catastrophic effects shown by AgNPs (20 nm) are more compared to AgNPs (40 nm).
DMD049817 735..743

Paroxetine, a selective serotonin reuptake inhibitor, is metabolized in the liver and excreted into bile and urine as metabolites, but species differences have been observed in hepatic disposition between rats and humans. A major metabolite in rats is M1glucuronide, whereas M1-glucuronide and M1-sulfate are found in humans. The primary excretion route of paroxetine-derived radioactivity in rats and humans is bile and urine, respectively. The aim of this study was to examine the usefulness of sandwich-cultured hepatocytes (SCH) to evaluate in vivo species differences of the hepatic disposition of paroxetine between rats and humans. The metabolite profile of [H]paroxetine in SCH was similar to that in hepatocytes in suspension, and the in vitro metabolite profiles were similar to the published in vivo metabolic pathways for both species. Furthermore, the biliary excretion index (BEI) of formed M1-glucuronide in rat SCH (25.8–50.9%) was higher than that in human SCH (15.1–16.7%). The BEI of formed M1-sulfate (16.4–29.1%) was comparable to that of M1-glucuronide in human SCH, whereas the BEIs of paroxetine were negligible in SCH of both species. Moreover, M1-glucuronide was demonstrated to be a multidrug resistance-associated protein 2 substrate in both species, as determined by its uptake into ATP-binding cassette transporter-expressing membrane vesicles. SCH should prove to be useful to evaluate the processes of hepatic uptake and metabolism of parent drugs and the simultaneous examination of the biliary excretion of both parent drug and liver-derived
AN INVTRO STUDY ON ANTI

Traditional systems of medicine have been in trend for treating numerous ailments in many develop and development countries such as India, China, Japan and Korea, Tavian since age system of medicine is one of the ancient traditional system southern part of India for treating different diseases including even chronic conditions. Nathai choori chooranam composed of five plant equal composition (Borreria hispida seed, Zingiber officinale Rhizome, Cassia auri molecules those may serve as safer therapeutics to combat existing new world ageing related diseases, and obesity is the major concern among them. Pancreatic lipase inhibito prove as promising side effects lacking anti objective of anti decoction. Phytochemica flavonoids, were done by taking tannic acid, quercetin, as reference molecules. Antiradical activities were evaluated by using different free radicals (ABTS, lipid peroxidation, meta and nitric oxide scavenging activities). Also effect of Nathai choori chooranam decoction on DNA cleavage induced by H decoction was proved to be better than the choori chooranam decoction was assessed using porcine pancreatic lipase (PPL; triacylglycerol lipase, EC 3.1.1.3) in an in vitro assay system with p data of the results obtained, maximum percentage of lipase inhibition was shown by Nathai choori chooranam decoction DNA cleavage.IC50 value were calculated using the logar after subtraction of both blank and inherent sample fluorescence values. In all cases, the coefficients of determination of the regression (R2) were greater than 0.95. IC50 are the means ± standard deviations of
The biological role of platelet-derived growth factor (PDGF)-AA in lung morphogenesis was investigated by incubating embryonic lung explants with phosphorothioate antisense PDGF-A oligonucleotides, which decreased PDGF-AA but not PDGF-BB protein content. Antisense PDGF-A oligonucleotides inhibited D

Branching morphogenesis of many organs, including lung, has been shown to take place in response to epithelial-mesenchymal tissue interactions (Rudnick, 1933; Wessels, 1977). The molecular signals guiding branching morphogenesis are largely unknown. As branching morphogenesis involves cell proliferation, migration and differentiation, the ontogenic sequence of these events in early lung organogenesis needs to be well coordinated. Polypeptide growth factors are believed to play a vital role in a number of these cellular processes. Platelet-derived growth factor (PDGF) expression studies have implicated PDGF in early embryonic development (Goustin et al., 1985, Mercola et al., 1990). PDGF is a dimeric molecule composed of two distinct but related polypeptides (A and B). The two chains assemble as a heterodimer, PDGF-AB, or as homodimers, PDGF-AA or PDGF-BB (Heldin, 1989). PDGF exerts its effect via specific cell surface receptors. Two types of PDGF receptors, designated α and β, have been characterized (Claesson-Welsh et al., 1988, 1989; Matsui et al., 1989). The PDGF α-receptor binds all three isoforms of PDGF whereas the PDGF β-receptor binds only PDGF-BB with high affinity (Hart et al., 1988; Heldin et al., 1988). The role of PDGFs in the early development of branched organs is unknown. We have previously shown that both PDGF homodimers, AA and BB, and both PDGF receptors (α and β) are present in the early embryonic lung (Han et al.,1992, 1993). To explore the physiological function of PDGFs in embryonic lung development, we have recently performed PDGF-BB loss-of-function studies and found that PDGF-BB is involved in regulating embryonic lung growth but not branching (Souza et al., 1994). To extend these studies, we now report that inhibition of PDGF-AA translation with phosphorothioate antisense PDGF-A oligonucleotides (ON) results in a significant reduction in lung size and branching. As PDGF-A is expressed in the epithelium and the α-receptor in the mesenchyme, these results suggest that PDGF-AA and its receptor influence early lung branching via an epithelial-mesenchymal interaction.
Stereotactic Approach Combined with 3D CT Reconstruction for Difficult-to-Access Foramen Ovale on Radiofrequency Thermocoagulation of the Gasserian Ganglion for Trigeminal Neuralgia.

OBJECTIVES The authors describe a technique that includes a stereotactic approach in the preoperative plan in cases where the foramen ovale is difficult to access for radiofrequency thermocoagulation of the Gasserian ganglion. METHODS The study included 395 patients for whom three-dimensional computed tomographic reconstruction of the skull base, maxilla, and mandible was conducted before surgery. Accessibility of the foramen ovale was defined using numerical data from the three-dimensional computed tomographic reconstruction images. In those patients for whom accessibility of the foramen ovale was considered difficult, the authors used a stereotactic frame to design an individual operative plan. Adjustments of a single point of data,-that is, a change in X axis, Y axis, or an arc angle-were guided by radiographic fluoroscopy images. After verifying successful cannulation and electroneurophysiology, thermocoagulation targets-especially multiple targets recorded as data on the Z axis of the stereotactic approach-were identified and treated. RESULTS There were 24 patients who met the predetermined criteria for having a difficult-to-access foramen ovales-that is, they had at least two contributing factors and/or involvement of division V1 . Twenty-one of the 24 patients required a single satisfactory puncture; three patients required two to three punctures to successfully access the foramen ovale. There were no permanent complications from the procedure. CONCLUSIONS The authors conclude that this stereotactic approach combined with three-dimensional computed tomographic reconstruction model can improve the accuracy, safety, and efficiency of percutaneous radiofrequency thermocoagulation in patients with trigeminal neuralgia for whom the foramen ovale is difficult to access.
Laboratory simulation of Martian atmospheric chemistry

Measurements of the yield of important trace gas species such as ozone, evolved during photolytic reactions have been made under Martian environmental conditions in one of the The Open University’s Mars simulation chambers. The simulation chamber can mimic Martian temperatures and pressures and a UV solar simulator can be added to irradiate a Marslike gas mixture within the chamber to drive chemical reactions. The concentration of trace gases is measured in situ using a Fourier Transform Infrared spectrometer (FTIR). The data obtained will be invaluable in improving the qualitative and quantitative representation of chemical species calculated using Mars global circulation models (MGCMs) and in interpreting a new suite of observational data such as from ExoMars Trace Gas Orbiter (TGO).
Possessive and non-identity relations in Turkic switch-reference

This paper provides an overview of non-canonical patterns of switch-reference involving the converb in -(V)p in selected Turkic languages. This converb is usually described as a same-subject converb, but we show that it can conform to McKenzie’s (2012) extended definition of “same-subject” as expressing the identity of topic situations, rather than subject referents. In addition to tracking cross-clausal subject identity, -(V)p can be used when the possessor of the subject of one clause corefers with the subject of another clause and when the events expressed by the two clauses are in a close temporal and/or causal relationship. Based on Stirling (1993) and Barany & Nikolaeva (2019), we argue that the role of possessors in Turkic switch-reference is captured by lexically specified conditions licensing the use of -(V)p when two subjects are in a possessive relation. Finally, we suggest that both types of non-canonical switch-reference can be seen as ensuring discourse continuity.
SÁMI CULTURE AS BASIS FOR MATHEMATICS TEACHING

A QRS-system (Barton, 1999) is a meaningful system that for a given group of people gives meaning to Quantity, Relations and Space. Each cultural group has their own QRS-system. This paper focuses on how the Sámi culture’s elements lavvu, lasso, skis and duodji can function as basis for mathematics teaching. The elements are described and mathematised (Freudenthal, 1973); made accessible to mathematics treatment. The elements are further categorised into two groups, Relations and Space. There will be pointed out possibilities for how to use these elements in mathematics teaching.
A CLASSIFICATION OF SECURITY PROPERTIES FOR PROCESS ALGEBRAS 1

Several information (cid:13)ow security de(cid:12)nitions, proposed in the literature, are generalized and adapted to the model of labelled transition systems. This very general model has been widely used as a semantic domain for many process algebras, e.g. CCS. As a by-product, we provide a process algebra similarto CCS with a set of security notions, hence relating these two areas of concurrency research. A classi(cid:12)cation of these generalized security de(cid:12)nitions is presented, taking into account also the additional property of input totality, which can in(cid:13)uence this taxonomy. We also show that some of these security properties are composable w.r. t. the operators of parallelism and action restriction.