Miracle-dz/UniFAR-FTUs huggingface dataset:
Forensic analysis of instagram and path on an iPhone 5s mobile device

Social networking applications are a treasure trove for forensic examiners. The amount of potential evidence that they hold could sway the course of any investigation. However, the large number of mobile operating systems, their continuous updates, and the constant emergence of new social networking applications in the market, create challenges for forensic practitioners today. This paper hopes to alleviate some of those challenges by conducting a forensic analysis on two popular social networking applications; Instagram and Path on an iPhone 5s mobile device. The analysis process consisted of installing both applications on the device, performing common user activities via these applications, obtaining a forensically sound logical image of the device, and finally conducting manual- and automatic (for result verification)-forensic analysis on the acquired image. The ultimate goal of the analysis was to determine whether the activities conducted through these applications are stored on the mobile device's internal memory or not. The test results show that a portion of the activities is indeed stored in the internal memory. Therefore, the significance, extent, and locations of the stored information were all determined and documented in this paper.
CRRC 2010 Euromed Management School, Marseille Rationale for Corporate Philanthropy: Syncretism & Altruism The Case of Homelessness in Mulhouse (France)

This paper investigates businesses’ approaches to homelessness; a social issue that is not often included in the agenda of Corporate Social Responsibility (CSR). It aims to provide an appraisal of the challenges facing the private sector on how business resources can strategically – i.e. preserving business interests – and effectively – i.e. meeting the needs of homeless people – contribute to the quest for social cohesion and the combat to eradicate homelessness. Theoretical propositions are drawn by integrating existing research on corporate philanthropy. These propositions are further developed using a case of business commitment to help homeless people in Mulhouse (France). The analysis leads to capture two dominant instrumental corporate values or pathways to CSR: solipsism and conspicuousness. Altruism is further identified as the genuine desire from agents of management to make a difference in society. This translates into (often discretionary) business philanthropic engagement. Altruistic commitment is understood to be limited to the willingness-to-act of business managers and the competence of the company in providing adapted solutions to help homeless people.
The Venture Capital Divide: Germany and the United States in the Post-War Era

This paper analyzes and explains the disparate paths of development among venture capital organizations in the United States and Germany over the post-World War II period, contrasting the early emergence and burgeoning of the sector in the U.S. with the lagging development in Germany. The paucity of venture capital in Germany throughout the latter half of the 20th century is often seen as a result of that country's system of large, powerful universal banks and small, inactive capital markets. Lack of acceptance may additionally appear to result from cultural or social differences that make Germans suspicious or skeptical of such risk-taking and disdainful of the capitalistic drive it represents. I argue instead that a complex of political, social, and economic factors - many dating back to institutions put into place in the 19th century - explains the evolution of venture capital over the post-war era. These factors differed radically between the U.S. and Germany and produced divergent outcomes for venture capital institutions a century later. I emphasize the crucial role of the available pool of qualified, potential entrepreneurs and the incentives that either drove or hindered high-technology venturing, particularly during the middle of the twentieth century.
Cognitive Interference Due to Food Cues in Childhood Obesity

Investigated specific information-processing biases for food-relevant stimuli in 34 children, Mage = 13 years, SD = 2 years, M = 177% of ideal weight, SD = 24%, who were completing a residential cognitive-behavioral treatment program for severe obesity and 40 matched control children who were not obese, Mage = 13 years, SD = 2 years, M = 103% of ideal weight, SD = 13%. Participants completed a computerized modified Stroop task, which included food words, negative-emotion words, and control words. Results indicated that children in the obesity group displayed a specific interference effect for food words. It is hypothesized that the observed bias in information processing reflects hypersensitivity for food cues, which can initiate or maintain dysfunctional eating behavior.
Poly[[aqua(μ7-biphenyl-3,3′,4,4′-tetracarboxylato)(1,10-phenanthroline)dicobalt(II)] monohydrate]

In the title compound, {[Co2(C16H6O8)(C12H8N2)(H2O)2]·H2O}n, one CoII ion has a {CoN2O4} distorted octahedral environment defined by two N atoms of one 1,10-phenanthroline (phen) ligand, three O atoms of the carboxylate groups of three biphenyl-3,3′,4,4′-tetracarboxylate (BPTC) ligands, one of which is bidentate, and one O atom from one coordinated water molecule. The other CoII atom is surrounded by six O atoms from four different BPTC ligands and one coordinated water molecule. Each BPTC ligand forms eight coordination bonds with seven CoII atoms, leading to a layer structure along the ac plane. Uncoordinated water molecules occupy the space between the layers, and interact via interlayer O—H⋯O hydrogen bonds along the b axis, generating a three-dimensional supramolecular network.
Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice.

Iodine-125-labeled monoclonal antibody 108.4 (108.4 mAb), raised against the extracellular domain of the epidermal growth factor (EGF) receptor, was shown to visualize sc xenografts of human oral epidermoid carcinoma (KB) cells in nude mice. In vitro, although EGF caused an increase in the number of KB cell colonies (150% at a concentration of 160 mM), the anti-EGF receptor antibodies reduced clone formation. At a concentration at which EGF caused a 50% increase in colony number, the addition of a 100-fold molar excess of 108.4 mAb resulted in a decrease in the number of cell colonies to 20% of the original value. Therefore, the effect of antibody on the KB tumor was studied in vivo in three different modes of tumor transplantation. Antitumor activity was demonstrated first by retardation (versus controls) of the growth of tumor cells as sc xenografts (P greater than .017), then by prolongation of the life span of animals with the ip form of the tumor (P less than .001), and finally on an experimental lung metastasis by a reduction in the number and size of tumors (P less than .05). When the anti-EGF receptor antibodies were added together with cisplatin, the antitumor effect was greatly enhanced, suggesting that the toxic activity of these agents is synergistic (P less than .007). The antitumor effect persisted when animals were treated with the F(ab)'2 fragment of the antibody, although it was less efficient. The Fab fragment of the antibody, whose ability to bind to the cell-associated receptor was completely conserved, did not affect the growth of the tumor. The activity manifested by the F(ab)'2 fragment of the anti-EGF receptor antibodies suggested that the antitumor effect was not due to immune mechanisms requiring the Fc portion of the antibody.
The technology of accelerometry-based activity monitors: current and future.

PURPOSE This paper reviews accelerometry-based activity monitors, including single-site first-generation devices, emerging technologies, and analytical approaches to predict energy expenditure, with suggestions for further research and development. METHODS The physics and measurement principles of the accelerometer are described, including the sensor properties, data collections, filtering, and integration analyses. The paper also compares these properties in several commonly used single-site accelerometers. The emerging accelerometry technologies introduced include the multisensor arrays and the combination of accelerometers with physiological sensors. The outputs of accelerometers are compared with criterion measures of energy expenditure (indirect calorimeters and double-labeled water) to develop mathematical models (linear, nonlinear, and variability approaches). RESULTS The technologies of the sensor and data processing directly influence the results of the outcome measurement (activity counts and energy expenditure predictions). Multisite assessment and combining accelerometers with physiological measures may offer additional advantages. Nonlinear approaches to predict energy expenditure using accelerometer outputs from multiple sites and orientation can enhance accuracy. CONCLUSIONS The development of portable accelerometers has made objective assessments of physical activity possible. Future technological improvements will include examining raw acceleration signals and developing advanced models for accurate energy expenditure predictions.
Aspiring School Administrators' Perceived Ability to Meet Technology Standards and Technological Needs for Professional Development

Abstract The merits of technology in general and of educational technology specifically are well documented. The use of educational technology has been shown to improve teaching and learning and the overall educational quality of schools. However, the successful integration of educational technology in schools hinges on school administrators' technology leadership abilities. The purpose of this study was to investigate aspiring school administrators' perceived ability to meet technology standards established by ISTE Standards for Administrators (formerly known as the NETS·A) and to determine which standards they wished to pursue for future professional development. Utilizing the ISTE Standards–A as a framework, a survey was created to decipher how aspiring school administrators perceived their own abilities to become leaders with foundational technology leadership skills. The findings showed that (a) the aspiring school administrators were more likely to indicate a need for professional development in technology utilization to meet the standards than they were to indicate their perceived current competence in meeting the technology standards and effectively utilizing technology in their schools; (b) when interests were examined by race, African American aspiring school administrators were more interested in pursuing professional development to enhance their abilities to perform the tasks than were Caucasian aspiring school administrators; and (c) there was a statistically significant difference between aspiring school administrators' average Perception and Interest scores. It appeared that in general, the participants perceived a greater need for professional development in technology standards than their perceived current ability to perform the standards.
Aligned core-shell nanofibers delivering bioactive proteins.

AIMS Continuous nanostructures embedded with proteins may synergistically present topographical and biochemical signals to cells for tissue engineering applications. This study presents the co-axial electrospinning of aligned poly(epsilon-caprolactone) nanofibers encapsulated with bovine serum albumin and platelet-derived growth factor-bb for demonstration of controlled release and bioactivity retention, respectively. MATERIALS & METHODS Controllable release kinetics is achieved by incorporation of poly(ethylene glycol) as a porogen in the shell of the nanofibers. RESULTS & DISCUSSION Poly(ethylene glycol) leaches out in a concentration- and molecular weight-dependent fashion, leading to bovine serum albumin release half-lives that range from 1 to 20 days. Optimized platelet-derived growth factor-bb-encapsulated nanofibers can completely release the protein with near zero-order kinetics and preserved bioactivity. CONCLUSION Co-axial electrospinning is shown to be a versatile technique in achieving the delivery of biochemical signals in a controlled manner for regenerative medicine applications.
A multidimensional proteomic approach to identify hypertrophy‐associated proteins

Left ventricular hypertrophy (LVH) is a leading cause of congestive heart failure. The exact mechanisms that control cardiac growth and regulate the transition to failure are not fully understood, in part due to the lack of a complete inventory of proteins associated with LVH. We investigated the proteomic basis of LVH using the transverse aortic constriction model of pressure overload in mice coupled with a multidimensional approach to identify known and novel proteins that may be relevant to the development and maintenance of LVH. We identified 123 proteins that were differentially expressed during LVH, including LIM proteins, thioredoxin, myoglobin, fatty acid binding protein 3, the abnormal spindle‐like microcephaly protein (ASPM), and cytoskeletal proteins such as actin and myosin. In addition, proteins with unknown functions were identified, providing new directions for future research in this area. We also discuss common pitfalls and strategies to overcome the limitations of current proteomic technologies. Together, the multidimensional approach provides insight into the proteomic changes that occur in the LV during hypertrophy.
[Individualized endovascular treatment of cerebral venous thrombosis: analysis of 168 patients].

OBJECTIVE To investigate the effects of individualized endovascular treatment on cerebral venous thrombosis of different types. METHODS 168 patients with cerebral venous thrombosis underwent individualized endovascular treatment: direct thrombolysis via internal jugular vein in 26 cases, injection of urokinase via common carotid artery in 98 cases, stent angioplasty in venous sinus in 9, simple anticoagulant therapy in 20 cases, and treating combined intracranial hemorrhage simultaneously in 15 cases. Follow-up was conducted for 6-168 months. RESULTS Follow-up showed that the effective rate was 97.6%, recurrence rate was 6.6%, complication incidence rate was 1.2%, and death rate was 0.6%. Venous sinus recanalization occurred and primary drainage rebounded in most eases. Lateral drainage was strengthened in some cases whose venous sinuses did not recover ideally. The symptoms of most cases were alleviated along with the decrease of intracranial pressure. CONCLUSION Individualized endovascular treatment based on the characteristics of the disease is effective in treatment of cerebral venous thrombosis.
Phosphorus restriction and control of coronary calcification as assessed by electron beam tomography

Purpose of reviewPatients suffering from end-stage renal disease and undergoing dialysis demonstrate extremely elevated cardiovascular morbidity and mortality rates. Though the prevalence of traditional risk factors is very high, the extent and severity of cardiovascular complications seem disproportionate to the underlying risk profile. Recent findingsA growing body of evidence indicates that abnormalities of calcium and phosphorus metabolism may play an important role in the morbidity and mortality of end-stage renal disease patients. Calcification of several cardiovascular structures, a likely complication of hyperphosphatemia and excessive calcium load, is both highly prevalent and extensive in end-stage renal disease patients and carries a negative prognostic weight. The extent of calcification can be accurately quantified with noninvasive radiological techniques such as electron beam tomography. Utilizing electron beam tomography in patients undergoing dialysis it has been possible to demonstrate the rapid progression of cardiovascular calcification and to gauge the effect of treatment provided to slow such process. SummaryThe presence of deleterious cardiovascular calcification in end-stage renal disease can be diagnosed accurately and noninvasively with electron beam tomography. This technology also allows precise assessment of the effect of medical treatment for hyperphosphatemia on calcification of cardiovascular structures.
Clinical Characteristics of Children With Hereditary Hemolytic Anemias and Aplastic Crisis: A 7-Year Review

We reviewed the clinical courses of children ≤16 years of age with hereditary hemolytic anemias who were admitted to the University of Mississippi Medical Center for aplastic crisis. Constitutional signs, gastrointestinal complaints, and headache were the most frequent findings. Statistically significant decreases in hemoglobin levels, hematocrit, and reticulocyte counts, but not total white blood cell or platelet counts, were found on admission when compared to other times of determination. For 27 of 49 patients, IgM antibody determinations to human parvovirus (B19) were available, and 15 (56%) had positive values. We conclude that erythroid (but not other) blood cell lines are helpful in establishing a clinical diagnosis, and that both acute and convalescent titers are necessary to assess the immune response to the infection. Physicians should continue to search for agents other than B19 parvovirus in patients in whom B19 antibodies cannot be found.
Democracy, governmentality and transparency: participatory budgeting in action

ABSTRACT This paper examines initiatives in participatory budgeting (PB) in a city in the United Kingdom, a country which is a slow adopter of PB. While there are UK initiatives on PB, these are developmental. Nevertheless, this study underlines the potential of PB in an Anglo-Saxon context. The finance of local government and cities is notoriously opaque. PB has the potential to enhance both democratic accountability and effective city management through transparency. This study reveals a city which is profitably engaged with democratizing its budgetary activities and seeking to achieve greater transparency for its citizens and managers through the modernization of established practice.
Update on hormone-refractory prostate cancer

Purpose of review Androgen deprivation therapy is the cornerstone treatment for men with de novo or recurrent metastatic prostate cancer. Unfortunately, androgen deprivation therapy is primarily palliative, with nearly all men progressing to an androgen-independent state. Hormone-refractory prostate cancer presents significant management challenges and is the focus of this review. Recent findings Investigations into the pathophysiology of hormone-refractory prostate cancer, the exploration of chemotherapeutic combinations, novel biological targets, skeletal protectants, and radiopharmaceuticals, as well as new prognostic tools are expanding the clinician's armamentarium and improving patient outcomes. Summary Bisphosphonates and chemotherapy are providing effective palliative approaches. Phase II trials of taxane-based regimens show higher response rates and longer survival than has typically been achieved with existing standards. Two completed randomized phase III studies to be reported in mid-2004 will more definitively answer the question of whether currently available chemotherapy can improve survival.
Molecular Characterization and Placental Expression of HERV-W, a New Human Endogenous Retrovirus Family

ABSTRACT The multiple sclerosis-associated retrovirus (MSRV) isolated from plasma of MS patients was found to be phylogenetically and experimentally related to human endogenous retroviruses (HERVs). To characterize the MSRV-related HERV family and to test the hypothesis of a replication-competent HERV, we have investigated the expression of MSRV-related sequences in healthy tissues. The expression of MSRV-related transcripts restricted to the placenta led to the isolation of overlapping cDNA clones from a cDNA library. These cDNAs spanned a 7.6-kb region containing gag, pol, and env genes; RU5 and U3R flanking sequences; a polypurine tract; and a primer binding site (PBS). As this PBS showed similarity to avian retrovirus PBSs used by tRNATrp, this new HERV family was named HERV-W. Several genomic elements were identified, one of them containing a complete HERV-W unit, spanning all cDNA clones. Elements of this multicopy family were not replication competent, asgag and pol open reading frames (ORFs) were interrupted by frameshifts and stop codons. A complete ORF putatively coding for an envelope protein was found both on the HERV-W DNA prototype and within an RU5-env-U3R polyadenylated cDNA clone. Placental expression of 8-, 3.1-, and 1.3-kb transcripts was observed, and a putative splicing strategy was described. The apparently tissue-restricted HERV-W long terminal repeat expression is discussed with respect to physiological and pathological contexts.
Metabolism of Hydroxylated and Fluorinated Benzoates by Syntrophus aciditrophicus and Detection of a Fluorodiene Metabolite

ABSTRACT Transformations of 2-hydroxybenzoate and fluorobenzoate isomers were investigated in the strictly anaerobic Syntrophus aciditrophicus to gain insight into the initial steps of the metabolism of aromatic acids. 2-Hydroxybenzoate was metabolized to methane and acetate by S. aciditrophicus and Methanospirillum hungatei cocultures and reduced to cyclohexane carboxylate by pure cultures of S. aciditrophicus when grown in the presence of crotonate. Under both conditions, transient accumulation of benzoate but not phenol was observed, indicating that dehydroxylation occurred prior to ring reduction. Pure cultures of S. aciditrophicus reductively dehalogenated 3-fluorobenzoate with the stoichiometric accumulation of benzoate and fluorine. 3-Fluorobenzoate-degrading cultures produced a metabolite that had a fragmentation pattern almost identical to that of the trimethylsilyl (TMS) derivative of 3-fluorobenzoate but with a mass increase of 2 units. When cells were incubated with deuterated water, this metabolite had a mass increase of 3 or 4 units relative to the TMS derivative of 3-fluorobenzoate. 19F nuclear magnetic resonance spectroscopy (19F NMR) detected a metabolite in fluorobenzoate-degrading cultures with two double bonds, either 1-carboxyl-3-fluoro-2,6-cyclohexadiene or 1-carboxyl-3-fluoro-3,6-cyclohexadiene. The mass spectral and NMR data are consistent with the addition of two hydrogen or deuterium atoms to 3-fluorobenzoate, forming a 3-fluorocyclohexadiene metabolite. The production of a diene metabolite provides evidence that S. aciditrophicus contains dearomatizing reductase that uses two electrons to dearomatize the aromatic ring.