Miracle-dz/UniFAR-FTUs huggingface dataset:
Saccharomyces arboricola and Its Hybrids’ Propensity for Sake Production: Interspecific Hybrids Reveal Increased Fermentation Abilities and a Mosaic Metabolic Profile

The use of interspecific hybrids during the industrial fermentation process has been well established, positioning the frontier of advancement in brewing to capitalize on the potential of Saccharomyces hybridization. Interspecific yeast hybrids used in modern monoculture inoculations benefit from a wide range of volatile metabolites that broaden the organoleptic complexity. This is the first report of sake brewing by Saccharomyces arboricola and its hybrids. S. arboricola x S. cerevisiae direct-mating generated cryotolerant interspecific hybrids which increased yields of ethanol and ethyl hexanoate compared to parental strains, important flavor attributes of fine Japanese ginjo sake rice wine. Hierarchical clustering heatmapping with principal component analysis for metabolic profiling was used in finding low levels of endogenous amino/organic acids clustered S. arboricola apart from the S. cerevisiae industrial strains. In sake fermentations, hybrid strains showed a mosaic profile of parental strains, while metabolic analysis suggested S. arboricola had a lower amino acid net uptake than S. cerevisiae. Additionally, this research found an increase in ethanolic fermentation from pyruvate and increased sulfur metabolism. Together, these results suggest S. arboricola is poised for in-depth metabolomic exploration in sake fermentation.
Heavy-Traffic Limits for a Special Type of State-Dependent Queueing Systems

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Correlation of Total IgE Level and Intensity of Infection among Soil Transmitted Helminthiasis Farmers in Klungkung Regency, Bali, Indonesia

The phenomena of increasing total IgE level in Soil Transmitted Helminthiasis and its protective role in resistance of infection remains unclear. The purpose of this study was to determine the correlation between total IgE and the intensity of Soil transmitted helminthiasis among farmers in these area. Total 162 farmer, age ranged 25-80 years participated in this cross sectional analytic study. Kato-Katz method was used to diagnose Soil Transmitted Helminthiasis and to determined infection intensity based on egg per gram (EPG). Total IgE levels were measured by enzyme linked flourescent assay (ELFA). The results of this study showed that 13,56% farmer positive for Soil Transmitted Helminthiasis, with single infection of Ascaris lumbricoides were 1,85%, 9,26% for Trichuris trichiura, 0,61% for Hookworm and mixed infection that were 1,23% for A.lumbricoides+T.trichiura 0,61% for A.lumbricoides+Hookworm. The intensity of infection were in mild category. Total IgE level in Soil transmitted Helminthiasis group was significantly different compared with noninfected group (p<0.05, t-test). There was significant correlation between EPG and total IgE level (r=0.667, p=0.001, Spearman test). As a conclusion total IgE level was significantly correlated with EPG, this fact can be used to develop management of Soil Transmitted Helminthiasis theraphy.
Non-Coding Mutations in Urothelial Bladder Cancer: Biological and Clinical Relevance and Potential Utility as Biomarkers

16 BACKGROUND & OBJECTIVE: Whole genome sequencing has identified recurrent non-coding mutations that may be important in carcinogenesis. We investigate the frequency of 5 such non-coding mutation hotspots in urothelial bladder cancers (UBCs) and assess their potential for UBC detection and prognostication. 17
Active Research Directions for Studying Repeat Tourist Behaviour

Repeat tourism has drawn increased interest among researchers recently. Various aspects of repeat tourism have been studied addressing key issues such as definition, methodology and underlying mechanism. The current article aims to highlight the discrepancies found in the research via a review of existing literature and specifically emphasize the active research directions for studying the repeat tourist behaviour. The main findings of the review are discussed with theoretical and practical implications. Keywords—repeat tourism; multiple visits; destination loyalty
Analysis of Assessment Alteration Phenomena of Subjective Quality of Experience Measurements in 2D and 3D Mobile Video Services

The growing importance of Quality of Experience over Quality of Service demands precise results in the monitoring of experienced quality; empirical assessment of subjective QoE measurement on perceived quality is expected to deliver accurate reflection of reality. The goal of this paper is to highlight potential errors in existing subjective QoE measurement methodologies. Our approach focuses on a special topic of distortions caused by preconceptions based on prior technical knowledge of evaluation measurement test subjects. The paper presents two series of measurements where the test subjects were aware of the service parameters during the evaluation of the given services. The paper specifies the identified distortion phenomenon and shows how cognitive dissonance played a role in the formation of evaluation patterns and the distortion of the Mean Opinion Score.
Commitment and cooperation in partnerships.

This thesis uses experimental methods to investigate whether pledges of commitment can improve cooperation in partnerships facing a social dilemma. In the game studied, subjects form partnerships endogenously and choose contribution levels to a partnership account. The treatments vary in terms of the individual’s (a) opportunity to commit to their partner, (b) the cost of dissolving committed partnerships, and (c) the distribution of these dissolution costs between partners. I find that pledges of commitment can increase cooperation levels within partnerships. Cooperation increases when committed partnerships can be dissolved without cost due to an increase in partnership stability; stable partnerships are more cooperative. I also find pledges of commitment improve cooperation when it is costly to dissolve a committed partnership. Dissolution costs are most effective when they are shared between committed partners because both partners respond to the threat of costly dissolution. Surprisingly, the increase in average cooperation when committed partnerships can be dissolved without cost is of similar magnitude to the increase when dissolution costs are equally shared between committed partners. JEL Classification Codes: C92, D03, D83, H41
Beer: The Key to Hoppiness

The microbrewery industry is on the rise these small-scale operations brew beer in small batch processes, leaving little room for experimentation on new beers. Our project aids Purgatory Beer Company in developing a new beer product by testing different combinations and concentrations of hops and chemically analyzing their flavors, aroma, and chemical structures. Our experiments determined that the amount of different hops used in a beer influences the flavor associated of a single hop. Additionally, our team analyzed trends in chemical compounds associated with the appealing and unappealing taste of the hopped beer samples. We suggest further research should be done using a more standardized panel tasting procedure with larger numbers on the panel.
The Connection Between Cyberbullying and Teenage Suicide: An Honors Thesis

The act of bullying within school systems has existed for a very long time; so long that there are decades of research that investigate the negative psychological impacts of bullying. However, currently, bullying has taken on a cyber form thanks to the invention of the internet and all the social media apps that follow. Young adolescents are using social media apps like Facebook, Twitter, Tumblr, and Instagram to keep in constant contact with each other, but bullies have used this tool as another way to harass their victims and send cruel and threatening messages to their victims. Within the last fifteen years, cyberbullying has gained increased coverage in the news, especially when teenagers end their own lives following excessive bullying online and by text messages. In response, research has been conducted on cyberbullying and suicide, and legislation has been developed to regulate and establish consequences for cyberbullying. This thesis provides a systematic literature review of research that has been done on cyberbullying and suicide. It begins by defining cyberbullying and presenting some nationally publicized cases in which cyberbullying appeared to play a role in the victims’ suicide. Next, characteristics of the bullies, as well as their motivations, are considered. Research on the relations between cyberbullying and suicide are then reviewed, with a discussion of limitations of these studies. Finally, a discussion of how the media have reported incidents of cyberbullying and suicide is provided, followed by a consideration of some of the school and legal policies concerning cyberbullying. With this thesis, I hope to bring more awareness of the issue of cyberbullying and inspire further scientific research as well as legal action and changes within schools.
COMPARATIVE STUDY BETWEEN MEPERIDINE, KETAMINE, AND ONDASETRON FOR PROPHYLACTIC MANAGEMENT OF POST-SPINAL SHIVERING IN PATIENTS UNDERGOING LOWER ABDOMINAL SURGERIES

Background: Shivering can be very unpleasant and physiologically stressful for the patient. It can be detrimental to patients with low cardio-respiratory reserve. Objective: The study was done to compare the effect of Meperidine, Ketamine, and Ondansetron in prevention of post-spinal shivering. Patients and Methods: This prospective randomized single blinded controlled clinical study was conducted on 120 patients under spinal anesthesia ASA I, II, undergoing lower abdominal and lower limb surgical procedures not exceeding 60 minutes. Patients were randomized into three equal groups. Group (A) received meperidine in a dose of 0.5 mg/kg.i. v, Group(B) received ketamine in a dose of 0.25 mg/kg.iv, and Group (C) received ondansetron in a dose of 4 mg. iv . All these drugs were given after subarachnoid block. Patients were evaluated by measuring shivering grade, HR, Systolic BP every 5 minutes for 60 minutes after interthecal injection. Shivering during spinal anesthesia was determindeded using a scale validated by Tsai and Chu. Blood pressure, heart rate and side effects were recorded. Results: There were statistical significant differences between Meperidine, Ketamine, and Ondansetron as Meperidine has a superior effect in prevention of shivering. No changes in systolic BP and HR. Conclusion: Meperidine and low dose ketamine (0.25mg/kg) were significantly more effective than ondansetron for prevention of post-spinal shivering in patients undergoing lower abdominal surgeries.
DISTINCTION DE REPRÉSENTATIONS AUTOMORPHES À L’AIDE D’UN NOMBRE MINIMAL D’OPÉRATEURS DE HECKE

Dans un précédent travail [14], l’auteur a calculé des traces du paramètre de Satake en p de certaines représentations automorphes algébriques régulières autoduales des groupes linéaires découvertes par Chenevier–Renard [2]. Pour des raisons d’ordre algorithmique liées au temps de calcul, les résultats ont été explicités jusqu’à p = 67 dans le meilleur des cas. S’est alors posée la question de savoir jusqu’à quelle valeur de p il était nécessaire d’aller pour déterminer sans ambigüıté les représentations automorphes considérées. L’objectif de cet article est de donner une borne explicite pour la valeur de p jusqu’à laquelle il faudrait calculer des opérateurs de Hecke (ou, de manière équivalente, des traces de paramètre de Satake).
Pathogenic Puppetry: Manipulation of the Host Actin Cytoskeleton by Chlamydia trachomatis

The actin cytoskeleton is crucially important to maintenance of the cellular structure, cell motility, and endocytosis. Accordingly, bacterial pathogens often co-opt the actin-restructuring machinery of host cells to access or create a favorable environment for their own replication. The obligate intracellular organism Chlamydia trachomatis and related species exemplify this dynamic: by inducing actin polymerization at the site of pathogen-host attachment, Chlamydiae induce their own uptake by the typically non-phagocytic epithelium they infect. The interaction of chlamydial adhesins with host surface receptors has been implicated in this effect, as has the activity of the chlamydial effector TarP (translocated actin recruitment protein). Following invasion, C. trachomatis dynamically assembles and maintains an actin-rich cage around the pathogen’s membrane-bound replicative niche, known as the chlamydial inclusion. Through further induction of actin polymerization and modulation of the actin-crosslinking protein myosin II, C. trachomatis promotes egress from the host via extrusion of the inclusion. In this review, we present the experimental findings that can inform our understanding of actin-dependent chlamydial pathogenesis, discuss lingering questions, and identify potential avenues of future study.
Penilaian Mahasiswa terhadap Jenis Media Pembelajaran dalam Penerapan Flipped Classroom

— Due to the rapid advancement of Information Technology, new ways of living are also developed. Learning styles are also affected. Internet proliferation in the last few decades has triggered the increasing adoption of online and blended learning. This article discusses students’ assessment to learning media in a flipped classroom application. There were 3 media studied: text and images, recorded slide show with audio narration
Stein Variational Gradient Descent for Approximate Bayesian Computation

Approximate Bayesian Computation (ABC) provides a generic framework of Bayesian inference for likelihood-free models, but sampling based posterior approximation is often time-consuming and has difficulty accessing the convergence. Stochastic variational inference forms the posterior inference to a optimization problem and enable the ABC scalable for large dataset. However, complex simulation models involved in ABC always lead to complex posteriors, which is not easy to approximate by simple parametric variational distributions. We draw upon recent advances in the implicit model of variational distribution and introduce the Stein variational gradient descent (SVGD) approach to approximate the posterior by nonparametric particles. We also find that the kernel in the SVGD algorithm helps in reducing the large variance of the gradient estimators of ABC likelihood. Moreover, energy distance is proposed as the statistics in the evaluation of ABC likelihood, which reduce the difficulty in selecting proper statistics. Simulation studies are provided to demonstrate the correctness and efficiency of our algorithm.
CHARACTERIZATION OF THE METAL BINDING BY THE ANTI-SPHINGOSINE-1-PHOSPHATE ANITBODY

OF THE THESIS Characterization of the Metal Binding by the Anti-Sphingosine-1Phosphate Antibody LT1002 by Michael Frank Erasmus Master of Science in Biology with a Concentration in Molecular Biology San Diego State University, 2012 During antibody development, two well-defined mechanisms, somatic recombination and hypermutation, serve to enhance antibody affinity to its antigen from a moderate to high binding. An alternative strategy, metal coordination, has not been widely considered. This is surprising considering the unique coordination properties that can be utilized by the incorporation of metals into the antigen-binding site. Recent characterization of an IgG antibody (LT1009) by X-Ray crystallography revealed the coordination of two interfacial Ca ions to specifically bind the phosphate group on sphingosine-1-phosphate (S1P). This brings forth interesting questions regarding processes of B-Cell development and the binding interactions that promote the downstream signals that eventually trigger B-cell affinity maturation. This study investigates this metal coordination property of the murine version of LT1009, called LT1002, in the absence of the S1P antigen. To do so we implement Flame Atomic Absorption, Induced-Coupled Spectrometry and Isothermal Titration Calorimetry to enable us to gain a fundamental understanding of the specificity of this metal coordination and the relative strength of the interaction. We incorporated several bioinformatic tools to iterate through thousands of immunoglobulin genes to see if the metal coordination motif is evolutionarily conserved and whether this antibody preserves a specific function. Lastly, we made initial advances on the expression of the genome encoded Fab region of LT1002 in BL21(DE3) E. coli cells in attempt to gather if this antibody retains its metal-binding capability.
Stress, Hypertension and Yoga

Stress and stress-related disorders are emerging as a major health challenge. In the classical stress concept, stress can be broadly defined as an actual or anticipated disruption of homeostasis by certain physical and psychological events that are known as ‘stressors’. Prolonged exposure to stress can lead to a destructive, self-per-petuating cascade of neuroendocrine, metabolic and neuropsychological alterations that play an important role in the development and progression of cardio-vascular disease (CVD) like hypertension. Dysregulation of stress system is causally linked to pathogenesis of essential hypertension, which involves over activity of hypothalamic-pituitary-adrenal axis (HPA) and sympathoadrenal system (SAS) and resetting of baroreceptors as the underlying pathophysiological mechanisms. Evidence suggests that regular practice of yogasanas and pranayama appears to cause down-regulation of the HPA axis and the sympathetic nervous system (SNS), increases vagal activity, improves baroreceptor sensitivity, and thereby helps to reduce blood pressure. Although the exact mechanism of beneficial effects of yoga are not known, evidence suggests that yogic intervention may be acting through multiple mechanisms simultaneously influencing diverse neural structures involved in the regulation of the neuroendocrine and the cardiovascular response to stress to cause neurohumoral modulations resulting in alleviation of stress and improvement in cardiovascular indices.
Numéro thématique-Surveillance de l ’ hypertension artérielle en France Special issue-High blood pressure surveillance in France

Coordination scientifique du numéro / Scientific coordination of the issue: Christine de Peretti, Institut de veille sanitaire, Saint-Maurice, France et pour le comité de rédaction : Sandrine Danet, Direction de la recherche, des études, de l’évaluation et des statistiques, Paris, France Numéro thématique Surveillance de l’hypertension artérielle en France Special issue High blood pressure surveillance in France
Codes in Structural Engineering

The structural safety assessment procedures proposed in Part 3 of Eurocode 8 (EC8-3) for the case of reinforced concrete structures are addressed. The practical evaluation of the member chord rotation demand according to EC8-3 is examined in detail along with several alternative formulations. The need for these formulations is demonstrated by presenting example situations where the EC8-3 proposal is difficult to apply. The effectiveness of the proposed approaches is assessed through an example application and recommendations for their practical use are defined. Romão, Delgado, Costa: A Study addressing the EC8-Part 3 Assessment Procedures . 1262
Make the Bag Disappear: Carrying Status-invariant Gait-based Human Age Estimation using Parallel Generative Adversarial Networks

Existing approaches to gait-based human age estimation seldom consider variations such as carried objects, which greatly alter appearance of gait features (e.g., gait energy images) and result in poor age estimation results. Therefore, we propose a method of gait-based human age estimation robust against carrying status using generative adversarial networks. Specifically, we consider a generative network that outputs a gait feature without carried objects (i.e., it makes the carried objects disappear) given an input gait feature with or without carried objects, and then learns the parallel generative network with shared weights from a pair of gait features of the same subject with and without carried objects. Thereafter, the generated gait features are separately fed into the same subsequent age regression network for age estimation, which is trained in an end-to-end manner in conjunction with the parallel generative network. Because of this design, the proposed method can generate gait features without carried objects that are suitable for gait-based age estimation regardless of the carrying status of the input gait features, and therefore improve the age estimation accuracy under carrying status variations. Experimental results on a large gait dataset with carried objects show the state-of-the-art performance of the proposed method.
Treatment of chronic patellar tendinosis with buffered platelet rich plasma: a preliminary study

1Sports Traumatology and Arthroscopic Surgery Unit, Galeazzi Orthopaedics Institute, IRCCS, Milan, Italy 2Department of Medical Pharmacology, Faculty of Medicine, University of Milan, Galeazzi Orthopaedics Institute, IRCCS, Milan, Italy 1Sports Traumatology and Arthroscopic Surgery Unit, Galeazzi Orthopaedics Institute, IRCCS, Milan, Italy 2Department of Medical Pharmacology, Faculty of Medicine, University of Milan, Galeazzi Orthopaedics Institute, IRCCS, Milan, Italy
On cluster structures of NHL players

The statistical analysis of NHL players has had a revolution in the 21st century after hockey teams have realized the possibilities of analysing and forecasting the performance of players based on their statistics. NHL teams have hired analysts, even academic statisticians, to try to find a way to harness the hidden information in statistics to give an advantage for their team. The movie called “Moneyball” (2011), which tells the story of a statistical analyst helping his baseball team to success, has been thought to be the starting point of the statistical revolution. In this thesis, clustering analysis is performed on the skater and forward statistics of the regular NHL season of 2016-17. The goal of this thesis is to investigate the capability of a clustering algorithm to separate the defenders from the skaters into their own clusters and if any of the resulting clusters can be labelled with identifiable player types. Different clustering methods and distance measures are presented, and the k-means++ algorithm with the Euclidean distance measure is chosen for the clustering analysis. The k-means++ algorithm was able to separate the forwards from defenders well. In addition, different player types, such as “enforcers” and “high-scoring/offensive-oriented players”, were also identified from the resulting clusters. For future research, different clustering algorithms and their performance should be investigated. In addition, a cluster analysis of goaltenders would be an interesting topic to investigate.