Miracle-dz/UniFAR-FTUs huggingface dataset:
Global Cities, Connectivity, and the Location Choice of MNC Regional Headquarters

One of the manifestations of the increasing diversity in multinational corporation (MNC) operations is the growing importance of regional headquarters (RHQs). RHQs assume an intermediary, bridging role between the corporate headquarters and local affiliates and other actors in their respective regions. They can have a coordination and control (i.e., administrative) mandate as well as an opportunity seeking (i.e., entrepreneurial) mandate. Since these mandates require RHQs to interact with various internal and external entities and exchange knowledge across distant locations, MNCs tend to locate their RHQs in highly connected “global cities” because these places allow the firm to economize on spatial transaction costs. In this paper, we explore the interplay between geographic distance, RHQ roles, and connectivity by analyzing which global city is selected by an MNC when establishing an RHQ. We argue that there is substantial heterogeneity among MNCs in the importance they attach to city connectivity—which we conceptualize as encompassing the effects of the international flows of people, knowledge, and services—because the connectivity needs of an RHQ varies in relation to its corporate mandate as well as to the geographic configuration of the MNC’s activities. Our mixed logit analysis of the location choices for 1,031 newly established RHQs in 48 global cities between 2003 and 2012 provides qualified support for the notion that the relationship between city connectivity and location choice is more pronounced for RHQs with an entrepreneurial role. Although the geographic distance of a city to the MNC’s regional affiliates discourages the establishment of RHQs with administrative roles, distance effects disappear when the city is highly connected. Moreover, well connected cities are able to attract MNCs’ RHQs from distant countries-of-origin.
Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways

The Jak (Janus) family of nonreceptor tyrosine kinases plays a critical role in cytokine signal transduction pathways. In Drosophila melanogaster, the dominant hop(Tum-l) mutation in the Hop Jak kinase causes leukemia-like and other developmental defects. Previous studies have suggested that the Hop(Tum-l) protein might be a hyperactive kinase. Here, we report on the new dominant mutation hop(T42), which causes abnormalities that are similar to but more extreme than those caused by hop(Tum-l). We determined that Hop(T42) contains a glutamic acid-to-lysine substitution at amino acid residue 695 (E695K). This residue occurs in the JH2 (kinase-like) domain and is conserved among all Jak family members. We determined that Hop(Tum-1) and Hop(T42) both hyperphosphorylated and hyperactivated D-Stat when overexpressed in Drosophila cells. Moreover, we found that the hop(T42) phenotype was partially rescued by a reduction of wild-type D-stat activity. Finally, generation of the corresponding E695K mutation in murine Jak2 resulted in increased autophosphorylation and increased activation of Stat5 in COS cells. These results demonstrate that the mutant Hop proteins do indeed have increased tyrosine kinase activity, that the mutations hyperactivate the Hop-D-Stat pathway, and that Drosophila is a relevant system for the functional dissection of mammalian Jak-Stat pathways. Finally, we propose a model for the role of the Hop-D-Stat pathway in Drosophila hematopoiesis.
Melatonin improves mitochondrial function in inguinal white adipose tissue of Zücker diabetic fatty rats

Mitochondrial dysfunction in adipose tissue may contribute to obesity‐related metabolic derangements such as type 2 diabetes mellitus (T2DM). Because mitochondria are a target for melatonin action, the goal of this study was to investigate the effects of melatonin on mitochondrial function in white (WAT) and beige inguinal adipose tissue of Zücker diabetic fatty (ZDF) rats, a model of obesity‐related T2DM. In this experimental model, melatonin reduces obesity and improves the metabolic profile. At 6 wk of age, ZDF rats and lean littermates (ZL) were subdivided into two groups, each composed of four rats: control (C‐ZDF and C‐ZL) and treated with oral melatonin in the drinking water (10 mg/kg/day) for 6 wk (M‐ZDF and M‐ZL). After the treatment period, animals were sacrificed, tissues dissected, and mitochondrial function assessed in isolated organelles. Melatonin increased the respiratory control ratio (RCR) in mitochondria from white fat of both lean (by 26.5%, P < 0.01) and obese (by 34.5%, P < 0.01) rats mainly through a reduction of proton leaking component of respiration (state 4) (28% decrease in ZL, P < 0.01 and 35% in ZDF, P < 0.01). However, melatonin treatment lowered the RCR in beige mitochondria of both lean (by 7%, P < 0.05) and obese (by 13%, P < 0.05) rats by maintaining high rates of uncoupled respiration. Melatonin also lowered mitochondrial oxidative status by reducing nitrite levels and by increasing superoxide dismutase activity. Moreover, melatonin treatment also caused a profound inhibition of Ca‐induced opening of mPTP in isolated mitochondria from both types of fat, white and beige, in both lean and obese rats. These results demonstrate that chronic oral melatonin improves mitochondrial respiration and reduces the oxidative status and susceptibility to apoptosis in white and beige adipocytes. These melatonin effects help to prevent mitochondrial dysfunction and thereby to improve obesity‐related metabolic disorders such as diabetes and dyslipidemia of ZDF rats.
Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate.

2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-adenine (Cl-F-ara-A) has activity against the P388 tumor in mice on several different schedules. Biochemical studies with a chronic myelogenous leukemia cell line (K562) grown in cell culture have been done in order to better understand its mechanism of action. Cl-F-ara-A was a potent inhibitor of K562 cell growth. Only 5 nM inhibited K562 cell growth by 50% after 72 h of continuous incubation. The 5'-triphosphate of Cl-F-ara-A was detected by strong anion exchange chromatography of the acid-soluble extract of K562 cells incubated with Cl-F-ara-A. Competition studies with natural nucleosides suggested that deoxycytidine kinase was the enzyme responsible for the metabolism to the monophosphate. Incubation of K562 cells for 4 h with 50 nM Cl-F-ara-A inhibited the incorporation of [3H]thymidine into the DNA by 50%. Incubation with 0.1, 1, or 10 microM Cl-F-ara-A for 4 h depressed dATP, dCTP, and dGTP pools but did not affect TTP pools. Similar inhibition of deoxyribonucleoside triphosphate pools was seen after incubation with 2-chloro-2'-deoxyadenosine. Both Cl-F-ara-ATP and Cl-dATP potently inhibited the reduction of ADP to dADP in crude extracts of K562 cells (concentration producing 50% inhibition, 65 nM). The effect of Cl-F-ara-ATP on human DNA polymerases alpha, beta, and gamma isolated from K562 cells grown in culture was determined and compared with those of Cl-dATP and 9-beta-D-arabinofuranosyl-2-fluoroadenine triphosphate (F-ara-ATP). Cl-F-ara-ATP was a potent inhibitor of DNA polymerase alpha. Inhibition of DNA polymerase alpha was competitive with respect to dATP (Ki of 1 microM). The three analogue triphosphates were incorporated into the DNA by DNA polymerase alpha as efficiently as dATP. The incorporation of Cl-F-ara-AMP inhibited the further elongation of the DNA chain, similarly to that seen after the incorporation of F-ara-AMP. Extension of the DNA chain after the incorporation of Cl-dAMP was not inhibited as much as it was with either Cl-F-ara-AMP or F-ara-AMP. Cl-F-ara-ATP was not a potent inhibitor of DNA polymerase beta, DNA polymerase gamma, or DNA primase. (ABSTRACT TRUNCATED AT 400 WORDS)
Economic order quantity models for items with imperfect quality and emission considerations

ABSTRACTIncorporation of quality and environmental concerns in production and inventory models has received considerable attention in the inventory management literature; however, researchers studied these topics mostly independently. Thus, it is required to jointly incorporate those two relevant aspects in a single research to support decisions, compare the results and obtain new insights for complexities in practice. This paper takes a step in this line of thought and revisits some economic order quantity (EOQ) models with imperfect quality from a sustainable point of view. The objective is to investigate the impact of emission costs on the replenishment order sizes and the total profit of a buyer (retailer) in an imperfect supply process, where the buyer receives the batches containing a percentage of imperfect quality items. First, an EOQ model with imperfect quality items and emission costs, which are the result of warehousing and waste disposal activities, is formulated. Next, the model is extended .
Changes in Chromatin Structure Associated with Alzheimer's Disease

Abstract— The enzyme micrococcal nuclease was used to examine the accessibility of chromatin extracted from brains of 13 patients with senile and presenile dementia of the Alzheimer type. Compared with chromatin extracted from brains of 8 patients without neurological signs or brain pathology and brains of 7 patients with nonAlzheimer dementia, Alzheimer chromatin was less accessible to this enzyme‐. Reduced accessibility was reflected by a reduced yield of mononucleosomes in comparison with dinucleosomes and larger oligomers. Both neuronal and glial chromatin were found to be similarly affected. The reduced yield of mononucleosomes from Alzheimer chromatin is not due to their increased breakdown, but is probably related to protein associated with the internucleosomal linker region that retards nuclease action. Dinucleosomes isolated from control and Alzheimer nuclease digests were examined for their protein complement. Three perchloric acid‐soluble proteins situated in the histone HI region of sodium dodecyl sulfate (SDS) gels were present in elevated levels in Alzheimer dinucleosomes. These results represent the first example of altered chromosomal proteins associated with a diseased state of the brain.
Planar High-Gain WLAN PCB Antenna

A simple design for a low-profile high-gain planar antenna has been presented in the letter. The antenna has the realized gain between 9 and 11 dBi and the return loss better than 10 dB over the 5.6-6.3-GHz frequency band, i.e. 11% bandwidth. A numerical study highlighting effects of key geometrical parameters on the gain and return loss of the antenna has been performed. It has been shown as well that the presented antenna occupies area 20% smaller than a conventional microstrip patch antenna array with a similar gain.
Genetic, Biochemical, and Physiological Characterization of Spinosad Resistance in Plutella xylostella (Lepidoptera: Plutellidae)

Abstract Bioassays (at generation G2) with a newly collected field population (designated MN) of Plutella xylostella (L.) (Lepidoptera: Plutellidae) from Multan, Pakistan, indicated resistance to spinosad, indoxacarb, deltamethrin, abamectin, and acetamiprid. At G2 the field-derived population was divided into two subpopulations, one was selected (G2 to G11) with spinosad (Spino-SEL), whereas the second was left unselected (UNSEL). A significant reduction in the resistance ratio for each compound was observed in UNSEL at G12, indicating that the observed resistance to each insecticide was unstable. For Spino-SEL, bioassays at G12 found that selection with spinosad gave a resistance ratio of 283 compared with MN at G2. The resistance to indoxacarb and acetamiprid in the Spino-SEL population increased to 13- and 67-fold, respectively, compared with MN at G2. The toxicity of deltamethrin to Spino-SEL was similar to its toxicity to the MN population at G2. This suggests that spinosad selection maintained the otherwise unstable resistance to the compound. In contrast, resistance to abamectin decreased significantly from G2 to G12 in Spino-SEL. Logit regression analysis of F1 reciprocal crosses between Spino-SEL and the susceptible Lab-UK indicated that resistance to spinosad was inherited as an autosomal, incompletely recessive trait. The spinosad resistance allele significantly delays the developmental time, reduced pupal weight, number of eggs laid, and number of eggs hatched compared with Lab-UK. Further analysis suggests Spino-SEL exhibited a significantly lower intrinsic rate of population increase (rm) to all other populations tested.
UVB Induces IL‐12 Transcription in Human Keratinocytes in vivo and in vitro

Human epidermal cells produce a wide range of cytokines, including those characteristic of Th2‐like responses such as interleukin (IL)‐4 and IL‐10. As well, keratinocytes have recently been shown to produce Th1‐like cytokines such as IL‐12. Exposure to UVB has profound effects on the skin and systemic immune system, which is in part mediated by secretion of tumor necrosis factor (TNF)‐α by epidermal cells. Because IL‐12 induces production of TNF‐α by certain cells of the immune system, we sought to determine whether UVB is an inducer of IL‐12 gene expression in epidermal cells. Human epidermal cells were exposed to UVB radiation in vivo, isolated by suction blister technique and trypsinization and transcription of the IL‐12 p35 and p40 chains was examined by RT‐PCR. We found the p35 chain of IL‐12 to be constitutively expressed and the p40 chain inducible by UVB irradiation. Because epidermis consists of a heterogenous cell population with distinct cytokine repertoires, we sought to determine the cellular source of the IL‐12 message after UVB exposure. After depleting UVB‐exposed epidermal cells for DR+ cells, no reduction in the IL‐12 activity was detected, suggesting that keratinocytes are a source of IL‐12 transcripts in UVB‐exposed human epidermis. This was supported by the up‐regulation of IL‐12 p40 transcripts in UV‐irradiated cultured keratinocytes that were devoid of DR+ cells. Up‐regulation of IL‐12 p40 gene expression by UVB as demonstrated here, taken together with the finding that keratinocytes also up‐regulate IL‐10 transcription, suggests that there is a complex interplay between Th1‐and Th2‐like epidermisderived cytokines following exposure to UVB.
Reduced adrenal cortical sensitivity to ACTH in lambs with cut splanchnic nerves.

The possibility that the sensitivity of the adrenal cortex to endogenous ACTH may be affected by splanchnic nerve activity has been investigated in conscious, weaned, 5- to 8-month-old lambs. The animals were atropinized (0.5 mg/kg) and tested with an i.v. infusion of noradrenaline (333 ng/kg per min for 10 min), which produced a significant rise in the mean concentration of both ACTH and cortisol in the arterial plasma. In lambs tested at least 7 days after section of both splanchnic nerves, just below the diaphragm, the rise in plasma ACTH concentration was significantly greater, and that in plasma cortisol significantly less, than in control lambs. The mean plasma ACTH and cortisol concentrations were linearly related to one another in both groups (r = 0.93 and 0.92) but the sensitivity of the adrenal cortex to the steroidogenic action of ACTH appeared to have been roughly halved 1 week after bilateral splanchnic nerve section.
Preoperative and postoperative immunological evaluation of patients with colorectal cancer

Twenty‐two patients with cancer of the colon and rectum were studied: preoperative and postoperative cell‐mediated and humoral immune factors were assessed, and local concentration of immunoglobulins in tumor tissue and in normal mucosa were measured. Lymphocyte function was found to be reduced in 50% of stage A and B and 66% of stage D patients. On the other hand, when the lymphoblastogenesis was performed in the presence of normal AB plasma, a partial restoration of lymphocyte function was noted, indicating the presence of a serum blocking factor in the blood of these patients. While there was no apparent decrease of B cell subpopulation, 57% of the tested patients showed significant reduction of T lymphocytes.
Extracting and presenting different viewpoints from political news articles

This study explores user interest in browsing different viewpoints from politicians and news agencies in news recommendation system. Along with providing personalized news articles to the user, bringing the opinion of politicians and news agencies about political events might be interesting for users. As there is always bias in publishing the news articles, newsreaders try to realize politicians’ opinions manually. We designed a prototype system to extract relevant politicians' viewpoints to a controversial event, and present them along with the news articles in the same user interface. We then observed user behaviour in browsing viewpoints vs. original news articles. According to the users’ clicks pattern analysis and their responses to the questionnaire they are interested in browsing the different viewpoints. This result suggests that news recommendation system could provide alternative recommendation criteria such as different viewpoints when recommending news articles.
Optimization of transient operations in sensorless control techniques based on carrier signal injection

Rotor position estimation techniques based on signal injection represent the only way to develop sensorless vector control schemes for permanent magnet synchronous motors able to operate at low and zero speed. Unfortunately an unwanted interaction between transient current components and signal produced by the injection makes necessary to inject a quite strong signal to accomplish a correct estimation. The injection of a strong signal causes extra power losses, while resulting in a poor exploitation of the DC bus voltage. The paper first analyzes the mechanisms that generate such a phenomenon. A new approach is then proposed to overcome any interaction that has been positively evaluated by experimental tests.
Sensitivity analysis of generic on-chip /spl Delta/I-noise simulation methodology

Power integrity, i.e. providing a stable voltage supply under the condition of rapidly changing current transients, gets increasing attention in the design of electronic packaging. Part of this discussion is the on-chip /spl Delta/I-noise. Various simulation methodologies, e.g. RAPiD, are known for simulation. Characteristic for these simulations is the very time consuming task of collecting and processing the complex input data, in order to optimise the required effort a sensitivity analysis for high-frequency on-chip /spl Delta/I-noise simulation has been carried out. This paper describes the results of this sensitivity analysis. A generic description of the on-chip /spl Delta/I-noise simulation methodology is shown. In particular the required input data is described. The sensitivity analysis quantifies the impact of each simulation parameter on the simulation results. The nominal value of each input parameter has been varied in a range from 0.5x to 2.0x compared to a nominal case. The maximum HF /spl Delta/I-noise is measured and plotted versus the respective input parameter deviation. The input parameters are categorized in high, medium and low impact parameters. This analysis results in guidelines which design parameters most efficiently reduce HF-noise and/or which input parameter need to be accurate in order to obtain accurate simulation results.
Worker substance use, workplace problems and the risk of occupational injury: a matched case-control study.

OBJECTIVE This study examines the tendency toward problem behavior as an explanation for the relationship between problem substance use and occupational injury. METHOD The authors used a matched case-control study nested in a cohort of 26,413 workers, in which cases (n = 3,994) were workers suffering an occupational injury. Five controls per case (n = 19,970) were selected from the cohort of workers active on the day of the injury and matched on job type. Conditional logistic regression modeled the association of problem substance use with occupational injury, controlling for problem behaviors and worker characteristics. Problem substance use was indicated indirectly if any of the following were alcohol/drug-involved during the comparison period: Employee Assistance Program visit, excused absence or disciplinary action. Discipline records identified minor (absenteeism) and serious (dishonesty, theft, assault, harassment, disrespect) problem behaviors during the comparison period. RESULTS The odds of injury among workers with an indicator of problem substance use was 1.35 (p = .015) times greater than the odds among workers without an indicator, controlling for job type and demographics as well as adjusting for exposure. This ratio declined to 1.21 (p = .138) when problem behaviors were also controlled for. Minor and serious problem behaviors were significantly associated with occupational injury (odds ratio [OR] = 1.73, p < .001, and OR = 2.19, p < .001, respectively), controlling for demographics and substance use. CONCLUSIONS The relationship of problem substance use with occupational injury was weak when problem behaviors were controlled for, suggesting that this relationship, observed in previous studies, may be explained by a workers tendency toward problem behaviors. Workplace injury prevention programs should address the expression of problem behaviors as a complement to drug and alcohol deterrent programs.
Salmonella and campylobacter contamination of raw retail chickens from different producers: a six year survey

Between 1995 and 2000, a prospective survey was undertaken to investigate the levels of contamination of raw retail chickens (n=1127) with salmonella and campylobacter. The levels of contamination over the 6-year period were 11% (95% CI±6·5%) for salmonella, and 57% (95% CI±9·5%) for campylobacter. S. Bredeney (20%) and S. Enteritidis (18%) were the dominant serovars. Although salmonella contamination was higher than in an earlier survey we conducted (7%), since 1998 it has declined to 6%. Many S. Enteritidis isolates (43%) were associated with one large integrated poultry organization that appears to have successfully managed the contamination, and the serovar has not been isolated since 1998. Contamination ranged from 0 to 44% between different producers. There was no significant difference between producers contributing large and small numbers of samples, although some small producers had much poorer contamination rates than others. S. Bareilly, S. Bredeney, S. Enteritidis and S. Virchow showed associations with particular producers. Campylobacter contamination remains high. Contamination ranged from 47 to 81% between different producers. This study did not show a temporal association between contamination of chickens and human campylobacter infections, indicating that many cases of human campylobacteriosis, particularly during seasonal peaks, do not originate from chickens. Control measures that have reduced salmonella contamination have been largely ineffective against campylobacter and new interventions are needed. Most raw chickens are contaminated with these pathogens, and communicating the importance of minimizing this risk to caterers and the public is vital in reducing human infections.