Miracle-dz/UniFAR-FTUs huggingface dataset:
Aktuelles zur intraventrikulÃ¤ren Blutung des FrÃ¼hgeborenen // Intraventricular hemorrhage in preterm infants â€“ an update

Intraventricular hemorrhage in preterm infants – an update. Despite continuous medical progress in neonatal intensive care intraventricular hemorrhage (IVH) is still a major cause of mortality and morbidity in preterm infants, which may result in poor neurodevelopmental outcome. Higher grades of IVH are associated with more severe neurodevelopmental sequelea due to white matter lesions. Long-lasting IVH and large hematomas are risk factors for developing posthemorrhagic hydrocephalus (PHH) or white matter lesions. Various temporizing neurosurgical interventions are used to achieve a controlled drainage of cerebrospinal fluid (CSF) during the acute state of IVH. Neuroendoscopic lavage (NEL) is a novel approach to remove hematoma and blood products from the ventricular system, which may help prevent disruption of CSF absorption due to venous occlusion. Additionally, distending of the ventricular system and consecutive development of venous infarction of the underlying white matter may be reduced. However, decreasing the number of permanent shunt insertion by half compared to previously used interventions seems to be the most important advantage of NEL. These positive results will be further investigated and compared in an ongoing prospective international multicenter study. J Neurol Neurochir Psychiatr 2019; 20 (4): 134–9.
CORRELATIVE CARDIOLOGY

Thus, although he states that artificial or invented dreams can be interpreted as if they were real ones (because unconscious forces go into the selection of the content), later on he is worried about the unreliability of the free associations of many patients because they are influenced by reading psycho-analytic literature. Thirdly, the author tries to cater for students much too diverse in their backgrounds. The glossary, for example, includes the following: "Haemorrhage: Bleeding; Typical: Pertaining to a type, an example, or a characteristic. " In short, for the elementary student, as for the experienced psychotherapist, there is not much here that is not to be found in the classical texts.
RDNA-12. THE FANCONI ANAEMIA (FA) PATHWAY AND GLIOBLASTOMA: A NEW FOUNDATION FOR DNA DAMAGE RESPONSE TARGETED COMBINATIONS

Treatment resistance in glioblastoma is underpinned by highly interconnected DNA damage response (DDR) processes. The FA-pathway is a fundamental DDR process required for the resolution of replication fork impeding lesions, and we have previously shown that it is inactive in normal brain, but is re-activated in glioblastoma, providing a cancer-specific target for combination DDR therapies. Here, we find that elevated FA-pathway gene expression in gliomas is associated with poor survival (-17.1% 5-year OS, p< 0.0001, n=329–REMBRANT). Furthermore, patient-derived glioblastoma stem cell (GSC) populations, which drive therapeutic resistance, display high FA-pathway expression relative to paired bulk tumour cell populations (mean 2.3-fold higher across genes, p=0.0073). We further show that inhibition of a single DDR process (FA-pathway, PARP, ATR or ATM) increases the susceptibility of glioblastoma cell lines and patient-derived GSCs to current adjuvant therapy. Importantly, clinically approved PARP inhibitor (PARPi) monotherapy stimulates robust FANCD2 mono-ubiquitination, supporting a role of FA-pathway activation in response to current DDR-targeted therapy. In clinically-relevant 3D GSC models, simultaneous inhibition of the FA-pathway (FAPi) and PARP or ATR enhanced temozolomide sensitisation compared to a single DDR inhibitor (DDRi). Furthermore, combined FAPi+PARPi consistently conferred radiosensitisation whilst combined FAPi+ATRi led to a profoundly radiosensitising effect; e.g. sensitizer enhancement ratio (SER0.37) of 3.23 (3.03–3.49, 95% CI). Furthermore, comparison of α/β ratio enhancement suggests dual-DDRi strategies fundamentally alter the response of GSCs, whilst single cell gel electrophoresis & immunofluorescence studies suggest FA-pathway based DDRi combinations profoundly delay the resolution of IR-induced DNA strand breaks at 6 hours post-treatment, with increased persistent DNA double strand breaks at 24 hours. In conclusion, simultaneously targeting the FA-pathway and interconnected DDR processes represents an appealing therapeutic strategy. Additionally, constitutive lack of FA pathway function in some tumours, could serve as a novel predictive biomarker for patient response to PARPi and ATRi currently in clinical trials.
FACTORS AFFECTING PREVENTION PRACTICES OF DENGUE FEVER WITHIN THE COMMUNITIES IN ACEH PROVINCE, INDONESIA

Dengue fever is a mosquito-borne disease that occurs in tropical and sub-tropical areas of the world. A severe form of dengue fever, also called dengue haemorrhagic fever, can cause severe bleeding, a sudden drop in blood pressure (shock) and death. The incidence of dengue fever has grown dramatically around the world in recent decades. The purpose of this study was to determine factors affecting prevention practices for dengue fever within the community. A cross-sectional study was conducted in the the municipality of Banda Aceh and district of Aceh Besar, Aceh Province, Indonesia. The sample size was 203, and the study instrument was a questionnaire. The study results showed that female respondents, 71 (75,5%) seem to have practiced prevention of dengue fever more as compared to the males (58,7%) or 64 respondents. Respondents in early adulthood (75 people or 54.7%) practiced more dengue prevention than older respondents. Meanwhile, respondents with higher levels of education, 85 (87.6%) practiced more dengue prevention than respondents with a middle level of education (47.2%) or 50 respondents. Respondents with good knowledge about dengue fever 128 (74%) practiced more prevention of dengue fever than respondent with a poor knowledge (23.3%) or 7 respondents. Respondents who had a positive attitude to the prevention of dengue fever, 108 (85.7%) practiced much more prevention than respondents who had a negative attitude (33.3%) or 25 respondents. Factors most affecting prevention practices for dengue fever were knowledge, attitude, education level, age and gender. Health promotion related to prevention of dengue fever should be done more in the media, especially using televison.
Remote sensing image classification based on attention mechanism and multi-scale features

Aiming at the problems of large change scale of remote sensing images and complex image backgrounds, which lead to poor classification of remote sensing scenes, a Multi-scale Convolution Block Attention Module(MS-CBAM) and an improved residual network-based remote sensing image classification method are proposed. Based on ResNet50, this method introduces multi-scale information into the residual structure and adds multi-scale convolution block attention module to improve the classification accuracy. The average classification accuracy on the public remote sensing image datasets UCMerced_LandUse and AID reached 94.10% and 93.52%. Compared with ResNet50, the classification accuracy was improved by 4.29% and 1.83%, respectively. Meanwhile, additional experiments verify the effectiveness of the multi-scale convolutional block attention module.
Differential Thickening and Thinning of Auditory Cortex in Deaf Cats Revealed with Ultra-High-Field MRI

In the absence of hearing, the brain must adapt and repurpose the former auditory cortex. In this study we scanned normal hearing (n=29) and deaf (n=26) cats to identify cortical areas of differing thickness using the auditory regions from a 3D cortical atlas. Compared to hearing controls, differential thickening and thinning was observed in specific regions of the deaf auditory cortex. More dorsal auditory regions tended to be bilaterally thicker in the deaf group, while more ventral regions in the left hemisphere were thinner. The location and nature of these changes creates a gradient along the dorsoventral axis wherein dorsal auditory cortical fields are thickened while more ventral fields are thinner in deaf animals compared to hearing controls. Whether this reflects the spatial separation between the functionally distinct “where” and "what" pathways, or a more general property of distance along the dorsoventral axis of cortex remains to be examined.
Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation

An unexpected BDCA-2+CD123+CD1a+ DC subset comprises a major DC population in acute human sterile skin inflammation. scRNA-seq shows these to be activated DCs able to express markers normally associated with plasmacytoid DCs, prompting a re-evaluation of previous studies.
Some Functional Measures of the Organism of Rats at Modeling of Ischemic Heart Disease in Two Different Ways

The study was conducted to examine the influence of two methods of modeling of ischemic heart disease on the amount of ischemic fibers in the myocardium parameters, characterizing the cardiovascular system, the coagulation properties of blood, and its electrolyte composition. It was shown that at modeling of IHD by introducing doxorubicin, several functional changes occurred, but the nature of the changes of the studied parameters evidenced a predominantly cardiotoxic effect of doxorubicin, which did not lead to the morphological picture characteristic of IHD. At modeling of ischemic heart disease by co-administering adrenaline and hydrocortisone, morphofunctional disorders were manifested in significant pathological changes in the myocardium of rats, and this method can be used as a model to identify the therapeutic efficacy of potential drugs aimed at preventing and treating the ischemic heart disease .
Dermoscopic profile of pityriasis rosea

Background: Pityriasis rosea (PR) is a common, self-limited cutaneous disease characterized by wide distributed erythematous scaly lesions. The diagnosis is usually based on the clinical features. Objectives: Here, we aimed to investigate the dermoscopic features of PR which may provide helpful clues to the diagnosis. Methods: Demographic, clinical, and dermoscopic features of the patients with PR were retrospectively reviewed, and the findings identified were recorded. Results: A total of 100 lesions from 25 different patients were included in the study. The most common dermoscopic finding was peripheral collarette scale (84%), followed by central yellow with peripheral reddish background (40%), peripheral dotted vessels with patchy distribution (35%), diffuse reddish background (31%), scattered dotted vessels (30%), and irregular distributed scales and red globules (20%). Conclusion: To the best of our knowledge, this is the most comprehensive study focusing on the dermoscopic features of PR. Here, we identified new dermoscopic findings which were not described previously for PR. These findings were irregular linear vessels, blood spots, brown globules, and brown structureless areas. It can be concluded that dermoscopy may provide remarkable clues to diagnosis, especially in atypical presentations of the entity.
Risk of immune-related diarrhea with PD-1/PD-L1 inhibitors in different cancer types and treatment regimens

Objective: To compare the incidence and severity of diarrhea among different tumor types and treatment regimens, and also compared with CTLA-4 inhibitors in randomized controlled trials. Methods: MEDLINE, PMC database and EMBASE were retrieved until December 2018. Studies were eligible if they were randomized controlled trials and included participants undergoing PD-1/PD-L1 inhibitors for cancer, measured a treatment side effect of diarrhea, and reported quantitative data. The risks of diarrhea in PD-1/PD-L1 inhibitors were compared among different treatment regimens. Results: Totally 21 studies involving 11554 patients were included for meta-analysis. For all-grade diarrhea, the risk after the PD-1/PD-L1 inhibitors plus CTLA-4 inhibitor combination was 1.90 times significantly higher than that of monotherapy, and the risk was 0.69 and 0.60 times significantly lower than that of monotherapy compared with chemotherapy and ipilimumab. The incidence of diarrhea was not significantly different between PD-1/PD-L1 inhibitor monotherapy versus placebo or between low-doses versus high-doses. For high-grade (grade ≥ 3) diarrhea, the risk after the PD-1/PD-L1 inhibitors plus CTLA-4 inhibitor combination was 3.29 times significantly higher than that of monotherapy, the risk in PD-1/PD-L1 inhibitors monotherapy was 0.50 and 0.38 times significantly lower than chemotherapy and ipilimumab respectively. No significant difference was found in the incidence of diarrhea between PD-1/PD-L1 inhibitor monotherapy versus placebo or between low-doses versus high-doses whether in all-grade or high-grade group. Conclusions: PD-1/PD-L1 inhibitors have a lower risk of developing diarrhea than chemotherapy and CTLA-4 inhibitor. There is no direct relationship between the dose of PD-1/PD-L1 inhibitors and the risk of developing diarrhea.
Sexual Therapy in Psoriasis? Is It Necessary?

In the review, it is reported that skin changes are one of the most important aspects of the psoriasis development. Because of this, psoriasis is diagnosed on the basis of observable skin changes and its treatment is one of the most difficult dermatological challenges [4]. These skin changes could influence on patients’ interpersonal relations, because of severity of skin changes which are very often visible. It should be noted that many different research fields have conducted extensive research on the appearance of skin. It is observed especially in the fields of medicine and cosmetology which have been most active in the study of skin appearance [2].
Under-reporting of energy and nutrient intake is a persistent issue in the Malaysian Adult Nutrition Surveys

Introduction: Under-reporting of energy intake is a common cause of bias in nutritional studies. This study was aimed at examining the extent of underreporting of energy intake and its related characteristics among respondents in the Malaysian Adult Nutrition Survey (MANS) 2003 and MANS 2014. Methods: The present study analysed energy intakes of 9,624 adults aged 18-59 years from the MANS in year 2014 (2,890 respondents) and 2003 (6,734 respondents) using a single 24-hour diet recall. Basal metabolic rates (BMR) were calculated from the ageand gender-specific equations of Schofield. Under-reporting was defined as an energy intake:BMR ratio of <1.2 as proposed by Goldberg. Results: Under-reporting was found to have increased significantly from 53% in 2003 to 61% in 2014. In both surveys, under-reporting increased with higher body mass index (BMI) and older age groups. It was higher among women than men, lowest among those with primary schooling or below, and those living in Peninsular Malaysia. It was higher among rural respondents in 2014 but higher among urban respondents in 2003. The intake of energy and micronutrients increased when under-reporters were excluded. Conclusion: Under-reporting was prevalent in both the nationwide MANS, and is associated with BMI, age, gender, education level, location strata, zone. It is important to take this factor into account when assessing dietary intake in population-based studies.
Enlarged Prostate

SIR,-Drs. S. Locket, P. G. Swann, and W. S. M. Grieve (April 14, p. 778) are to be coigratulated on their presentation of a very important body of work on the management of hypertension, on their critical attitude which will temper over-sanguine expectations in the minds of those lacking their experience, and on their emphasis on the possible importance of the ion with which the methonium is combined. Dr. Gavin Shaw and I have for fifteen months been using hexamethonium bromide, orally administered to ambulant patients, and our earlier patients have been continuously on methonium for this period of time. On the whole, our results (which should shortly be published) have been more satisfactory than those of Locket, Swann, and Grieve. A hypotensive effect, lasting as long as six hours, may be obtained by a single oral dose of methonium. Since this effect is obtainable with the first dose administered, it can have nothing to do with a bromide effect. By suitable spacing of the dosage, it is possible to achieve an almost continuous lowering of the blood pressure. We have rarely been able to give much more than 3 g. per day without reduction of blood pressure to a disabling level. Adjustment of dosage is not easy, because the margin between an ineffective and a disabling dose appears to be small. On effective dosage, the patients always show a degree of postural hypotension. It may well be that, just as after a successful sympathectomy, this postural hypotension has an important effect in diminishing the strain on the heart and vessels. Moreover, even though it be impossible with methonium to produce an uninterrupted reduction in blood pressure, it is reasonable to suppose that the lowering of the pressure for several periods of a few hours in the course of the day may be beneficial. -I am, etc.,
Why not add some SPARKL to your life (and death)!?

ABSTRACT Quantifying cytostatic and cytotoxic outcomes of cells responding to perturbagens is an essential component of mechanism-based studies and pharmacological screening approaches. We recently described an easy and versatile method for single-cell and population-level analyses using real-time kinetic labeling (SPARKL). This technology enables zero-handling, non-disruptive protocols for integrating proliferation profiles with cell death mechanisms, along with advanced mathematics for robust analyses.
Dependiendo de la nutrición parenteral para sobrevivir. Falla intestinal crónica por síndrome de intestino corto. Comunicación de un caso y revisión de la literatura

Short bowel syndrome consists of intestinal failure after a massive intestinal resection. It is an unusual condition, ranging from a mild and reversible malfunction to a severe condition causing inability. Short bowel syndrome has high morbimortality, high medical costs and a significant impact on quality of life. 50% of patients with short bowel syndrome do not spontaneously adapt and neither does absorption improve by the remaining intestine, thus they depend on parenteral nutrition for the rest of their lives. Specialized nutritional therapy and focalized hormone therapy in the intestine are pillars in rehabilitation. They promote intestine adaptation and achieve independence from parenteral nutrition and avoid intestinal transplant. Today, Teduglutide is the reference treatment for these patients, although it is still not available in Uruguay due to its high cost. The study presents a 23 year old patient carrier of chronic intestinal failure due to short bowel syndrome who has depended on parenteral nutrition for 17 years and presents severe complications associated to this technique.
Modulating effects of a decoction of a traditional Japanese herbal formula, hochuekkito (with Hedysari radix and Atractylodis rhizoma), on the local mucosal immune system of aged mice

Hochuekkito is generally considered to express its clinical effects through modulation of the immune system. The formula using Hedysari radix and Atractylodis rhizoma as the component herbs, also has been used clinically as hochuekkito, but its immunopharmacological activity has not been clarified.
Powder Microscopic, Physicochemical, HPTLC and Antioxidant Studies on Noccik Kudinir Chooranam – A Polyherbal Siddha Formulation

Objectives: To study pharmacognostical, physico-chemical, high performance thin layer chromatography and anti-oxidant activity potential of a Siddha drug “Noccik Kudinir Chooranam” (NKC). Methods: The raw drugs were collected, authenticated and the Kudinir Chooranam was prepared. Then the drug was subjected to powder microscopic diagnosis, physicochemical parameters, Thin Layer Chromatographic photo documentation (TLC), High Performance Thin Layer Chromatographic (HPTLC) finger print profile of successive hexane, successive chloroform, successive ethanol, hydro alcohol (1:1) extract, ethyl acetate solubles of water extract, alkaloid fraction and direct ethanol along with ingredients. The methanol and aqueous extracts were evaluated for total phenol and flavonoid, DPPH radical scavenging activity and superoxide scavenging activities. Results: Different extracts of the drug showed distinct TLC and HPTLC finger print patterns which will be unique to this drug. The antioxidant activity showed significant results which are comparable to standards. Conclusion: The identified powder microscopic characters and the evolved physicochemical parameters would serve as reference tool for quality control and the antioxidant activity would find the much wider therapeutic importance of the drug. Key words: Noccik Kudinir, Vitex negundo, Allium sativum, TLC, HPTLC, Antioxidant activity.
HIF-1a Regulating the Chemoresistance By Upregulating the Expression of xCT and GCLM in the Diffuse Large B Cell Lymphoma

Background Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-hodgkin lymphoma with great heterogeneity in clinical behavior and response to treatment. Although the addition of rituximab to CHOP regimen has significantly improved the survival of DLBCL, 1/3 will be eventually relapse and progression. HIF1a has been reported to be related with the drug resistance in DLBCL, but the mechanism remains unknown. Methods Two DLBCL cell lines (Riva and SuDHL2) were treated with doxorubicin and HIF-1a inhibitors digoxin, YC-1. The proliferation of these cell lines (Riva and SuDHL2) were measured by MTT and apoptosis were detected by FCM after staining with Annexin V/SYTOX Green. Expression of IF-1α, PHD, xCT, GCLM and apoptosis-related proteins was detected by Western Blot. Results With the increase concentration of doxorubicin treatment, the proliferation of Riva and SuDHL2 cell lines could be gradually inhibited. xCT and GCLM expression were upregulated after treated with doxorubicin and can be reversed by N-acetylcysteine. HIF-1a inhibitors digoxin and YC-1 could inhibited the expression of xCT and GCLM, proliferation and apoptosis induced by doxorubicin. Furthermore, we treated shHIF-1a RNA to significantly reduce the expression of HIF-1a, and the decrease of HIF-1a expression enhanced the proliferation inhibition and apoptosis of lymphoma cells by Dox. Downregulation the expression of HIF-1a by shRNA enhanced the doxorubicin induced apoptosis and inhibited the proliferation in DLBCL cell lines. Conclusions Taken together, our results showed that HIF-1a could regulate the expression of xCT and GCLM and further mediate drug resistance in the diffuse large B cell lymphoma. No relevant conflicts of interest to declare.
Functional status of the central nervous system in girls aged 16-18 years old

The objective of the study was to explore the dynamics of the functional state of the central nervous system (CNS) and neurophysiological processes of girls 16-18 years old in the context of their transition to a new level of social organization. Material and methods. The functional state of the CNS was studied in girls 16-18 years old in a state of relative muscular rest through observation of visible motive reactions, Loskutova’s method, and in the fifth minute of renewal after the physical loading with variable power. Results. We found that 17 year-old girls had the best functional CNS capabilities. The reduced adaptive capacity of the CNS in 16 year-old girls is due to their necessity for adaptive reorganization of regulatory mechanisms to new social conditions: examinations and university entry. After physical activity, 16 and 18 year-old girls registered stress reactions, indicating decreased CNS adaptation. Conclusions. 17 year-old girls were observed at rest to have better CNS functionality compared to the other age groups. Analysis of the dynamics of the functional CNS states of 16–18 year-old girls after exercise resulted in the identification of two main reaction types: 1) reduction of the basic criteria at high initial values; 2) increase of criteria of a general functional state of a brain at low raw data.