Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comparison of β-Adrenergic Receptors and In Vitro Relaxant Responses to Isoproterenol in Asthmatic Airway Smooth Muscle

In previous reports, we have documented decreased in vitro airway smooth muscle responses to isoproterenol (ISO) in fresh postmortem trachea and bronchus from subjects with fatal asthma. One hypothesis to explain this finding is a decrease in β-adrenergic receptor (βAR) numbers on airway smooth muscle. We have now examined the autoradiographic distribution and density of βAR using [125I]iodocyanopindolol on sections of airway smooth muscle adjacent to those studied functionally. The results have been compared with “normal” trachea and bronchi obtained from persons dying suddenly of nonpulmonary causes. In both trachea and bronchi, there was a 2.8-fold and 2.5-fold increase in specific grain counts, respectively, over smooth muscle from asthmatic airways (n = 6) compared with that determined in normal airways (n = 4, P < 0.01, unpaired t test). The affinity of the βAR for the agonist ISO, as determined by competitive binding experiments with increasing concentrations of (−)-ISO on tissue sections, was incr.
Psychiatric morbidity among continuing care geriatric inpatients

This study examines the point prevalence of psychiatric morbidity among continuing care geriatric inpatients and the performance of screening questionnaires in detecting such morbidity. From a sample of 74 patients it was possible to carry out complete dementia ratings in 53 patients and depression ratings in 52 patients. Eighty‐three per cent of the patients assessed had dementia and 48% had significant depressive symptoms. Screening for dementia with the Mini Mental State Examination (MMSE) had 100% sensitivity and 78% specificity. The Geriatric Depression Scale (GDS) had 80% sensitivity and 64% specificity at the conventional cutoff of 10/11. Receiver operating characteristics curve analysis suggested that a 12/13 cutoff gave the best sensitivity (75%) and specificity (73%) values for depressive symptoms. Among patients with dementia a cutoff score of 12/13 on the GDS also gave optimal sensitivity, specificity and positive predictive values. The GDS revealed good test–retest stability in the whole sample (tau = +0.55, p < 0.001) and the demented subgroup (tau = +0.52, p < 0.001).
Working Around the Military: Challenges to Military Spouse Employment and Education

Abstract : Successful recruiting and retention of the active duty force relies in large part on the extent to which service members and their spouses experience both job satisfaction and contentment with life in the military. In his February 12, 2001, speech at Fort Stewart, Georgia, President Bush acknowledged the importance of caring not just for service members but their entire families, pledging, "We owe you and your families a decent quality of life. Service members deserve a military that treats them and their families with respect. A major challenge to ensuring familywide quality of life is overcoming the hurdles to military spouse employment. Data indicate that the majority of military spouses are in the workforce; however, research indicates that they have difficulty finding jobs and that limited career opportunities for military spouses may be a factor in military personnel leaving the service. Given its impact on service member contentment and retention, spouse employment and education is thus an area of significant concern to the military. This study seeks to (1) provide a richer and more detailed depiction of military spouse employment and earnings, (2) explore the degree to which employment is problematic for military spouses, and (3) identify policies to reconcile spouse employment issues with the military's need to retain qualified personnel.
Analysis of novel targets in the pathobiology of prostate cancer

The process of developing a greater understanding of the fundamental molecular mechanisms involved in prostate carcinogenesis will provide insights into the questions that still plague the field of prostate cancer research. The goal of this study was to identify altered genes that may have utility either as biomarkers, for improved diagnostic or prognostic application, or as novel targets important in the pathobiology of prostate cancer. We hypothesize that an improved understanding of the genomic and proteomic alterations associated with prostate cancer will facilitate the identification of novel biomarkers and molecular pathways critical to prostate carcinogenesis. In order to enhance our knowledge of the molecular alterations associated with prostate cancer, our laboratory performed microarray analysis comparing gene expression in healthy normal prostate to that in prostate cancer tissue. Of the greater than 400 genes with significantly altered expression identified in our study, MT2A, Tacc2, Nell2, FosB, PCP4, and Cyr61 were selected for further evaluation to confirm expression changes and evaluate their potential impact in prostate cancer. Analysis of MT2A, Tacc2, and Nell2 expression patterns failed to demonstrate significant changes between prostate cancer and donor prostate tissue and, therefore, these results do not support their further development as prostate cancer biomarkers. We demonstrated that PCP4 was expressed predominently in the stromal compartment of the prostate and was expressed at similar levels in the stroma of normal and prostate cancer tissue. Interestingly, protein expression of PCP4 in a panel of colon cancer tissues was dramatically higher in adenoma and adenocarcinoma tissues compared to donor and benign colon tissue and, consequently, we feel that PCP4 has more potential as a biomarker in colon cancer than in prostate cancer. We also demonstrated that FosB and Cyr61 were upregulated in prostate cancer tissues over donor prostate tissues. Based on expression analysis of FosB and expression and functional analysis of Cyr61, we believe that these two targets have the greatest potental to be functionally significant in the etiology of prostate cancer.
Counterproductive Juvenile Justice

Abstract By describing evaluations demonstrating that carefully planned and executed interventions can have harmful effects, the author argues that programs to prevent crime should be tested for safety as well as efficacy. Although client reports of benefits and improvements over predicted outcomes would have suggested benefits from intervention, randomly assigned matched cases used in one such comparison showed that an intervention lasting more than five years increased the likelihood of serious crime, alcoholism, early death, and mental illness.
Concurrent training and functional training promotes beneficial changes in body composition and nonalcoholic fatty liver of obese youth

To compare the effect of concurrent and functional exercise training on body composition, lipid profile and non-alcoholic steatohepatitis in obese adolescents. Longitudinal/analytical study by non-random sampling carried out with 49 obese adolescents (n=36 in concurrent and n=13 in functional exercise training). Both protocols had 50% of the session designed to aerobic activities and the other half session to resistance and functional training (activities using self-body weight and dumbbells). Set data had normal distribution and the paired sample t test was applied. Concurrent exercise training decreased low density lipoprotein (-16.45%), total cholesterol (-11.55%), body fatness (-8.52%), trunk fatness (-9.95%) and increased fat free mass (5.05%). On the other hand, functional exercise training decrease body fatness (-4.97%), trunk fatness (-5.11%), intra-abdominal adiposity (-19,9%), increase fat free mass (4.18%) and occurrence of non-alcoholic steatohepatitis (reduction of 76.9%). Concurrent training seems a relevant tool to the treatment of non-alcoholic steatohepatitis in obese adolescents.
The Inner World of Mental Illness ed. by Bert Kaplan (review)

with the descriptions of curare, chaulmoogra, sarsaparilla, and yams. The last part of the book is devoted to "Frontiers ofResearch. " It opens with an interesting account of periwinkles and the promise of active principles from them which might be useful in cancer. There is an admirable account ofrauwolfia, the Hindu "snakeroot" which contains so many active chemicals useful in psychotic conditions. This introduces a considerable discussion of drugs for mental conditions, including compounds of ergot, morning glory, and mushrooms. The book ends with brief descriptions of drugs from the sea and an enthusiastic closing about the way in which the worldwide search continues.
Fact or Fiction? The MSG Controversy

Monosodium glutamate (i? ½MSGi? ½) has become one of the most well-known and controversial food ingredients in recent history. Linked to the i? ½Chinese Restaurant Syndrome,i? ½ the use of MSG has caused an outpouring of anecdotal evidence alleging adverse effects caused by ingestion of the food ingredient. These claims have been fueled by the popular press which has devoted considerable coverage to the debate surrounding the food additive. Yet, scientific studies have repeatedly indicated that MSG is safe at ordinary levels of consumption for the general population. In response to the controversy, in 1995, the Food and Drug Administration commissioned the FASEB Report to provide a comprehensive review of the monosodium glutamate scientific literature. This paper will examine the history of the MSG debate, including the scientific evidence, the role of the media, the positions of both sides and the response of the FDA.
Ferramenta Computacional para Análise de Antenas Filamentares Utilizando o Metodo dos Momentos

Resumo— Este trabalho apresenta a construç̃ ao de uma ferramenta computacional, que realiza o ć alculo da distribuição de corrente em antenas filamentares utilizando o Ḿetodo dos Momentos. Para tanto, foram utilizadas diferentes abordag ens: o Point-Matching e o Método de Galerkin. Ambas foram implementadas em ambiente MatlabR ©. Para demonstrar o uso da ferramenta, um dipolo de meia-onda foi analisado considera ndose diferentes tipos de funç̃ oes base. Em termos de diagrama de irradiaç ão, verificou-se que a escolha da funç ão base ñao afeta os resultados de forma significativa. Um estudo da converĝ encia do MoM para o cálculo da impedância de entrada de um dipolo de meia-onda foi realizado, no qual foi possı́vel verificar quetodas as curvas tendem para o mesmo valor quando a discretizaç ̃o do dipolo é aumentada, independentemente da funç ão base adotada.
Epidemiology of the pseudo‐exfoliation syndrome, A review

Pseudo-exfoliation syndrome (PE syndrome) is a condition with worldwide distribution. 2) Marked geographical variations have been demonstrated. 3) En- vironmental factors may be of etiological significance for the development of PE syndrome. 4) The PE syndrome's ability to promote glaucoma may vary from one area to another. 5) There seems to be a trend towards lower debut age of PE syndrome at lower latitudes. 6) More prevalence studies from different parts of the world are needed. A standardized set-up of such works would facili- tate comparison of the results, and so some guidelines have been proposed.
The metabolic syndrome among hypertensive patients: a cross-sectional study

Background: Hypertension is the key component of the metabolic syndrome (MS). Insulin resistance is regarded as the underlying pathophysiological basis of the clustering metabolic abnormalities associated with the MS. Increased cardiovascular risk in hypertensive patients might be partially attribute to metabolic disturbance. This study was undertaken to determine the prevalence of the metabolic syndrome and its individual components among hypertensive patients using the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria in a tertiary healthcare centre in Ahmedabad. Methods: This was a cross-sectional observational study in a sample of 200 patients with high blood pressure (aged ≥20 years) Informed written consent was taken. The following measurements were taken: blood pressure; Body Mass Index (BMI); waist and hip circumferences; plasma glucose, lipid levels; High blood pressure criterion: average systolic blood pressure ≥140mmHg and/or diastolic blood pressure ≥90mmHg; Metabolic Syndrome diagnosis according to NCEP ATP III criterion. Results: Prevalence of metabolic syndrome was 44.5% (n=89) inpatients of hypertension. The prevalence of metabolic syndrome was higher in women 62.92% (n=56) as compared to men 37.08% (n=33). The most common abnormality found was obesity (high waist circumference), seen in 91.01% (n=81), followed by low HDL-C in 40.5% (n=72) an abnormal triglyceride level in 32% (n=69) and abnormal FBS 34% (n=65). Amongst all females 92.4% (n=98) had an abnormal HDL-C levels followed by an abnormal waist circumference in 52.38% (n=55). Incidence of abnormal FBS and TG in females were 30.5% (n=33) and 32.4% (n=35) respectively. Conclusions: The prevalence of the metabolic syndrome is high among newly diagnosed hypertensive patients. This underscores the importance of routine screening of hypertensive patients for other cardiovascular risk factors.
Hubungan Kadar Visfatin Serum dan Tingkat Keparahan Psoriasis di RSUP Dr. Mohammad Hoesin Palembang

Psoriasis merupakan penyakit kulit kronik ditandai Perubahan kulit tipikal. Patogenesis diduga berhubungan dengan aktivasi sel T helper (Th)1, Th17, dan Th22 serta inhibisi regulatory T lymphocytes (Treg). Visfatin merupakan protein yang dihasilkan oleh white adipose tissue, diduga memiliki peran dalam modulasi respon imun dan inflamasi sehingga mempengaruhi tingkat keparahan psoriasis. Penelitian ini bertujuan untuk menganalisis hubungan kadar visfatin serum dengan tingkat keparahan psoriasis. Penelitian observasional analitik laboratorik dengan rancangan potong lintang dilakukan pada bulan Februari sampai dengan April 2014 di Poliklinik IKKK Divisi Alergo Imunologi RSUP Dr. Mohammad Hoesin Palembang. Empat puluh pasien yang memenuhi kriteria inklusi diikutsertakan sebagai subjek penelitian secara consecutive sampling. Pada semua subjek penelitian dilakukan pemeriksaan kadar visfatin serum dan penilaian keparahan klinis psoriasis berdasarkan total skor PASI. Korelasi positif kuat antara PASI dan kadar visfatin serum menggunakan Pearson correlation (0.089, p = 0.000), terdapat perbedaan signifikan skor PASI pada kadar visfatin serum normal dan tinggi menggunakan Student's t test (p = 0.000). Analisis regresi ganda menunjukkan hanya kadar visfatin serum yang berhubungan dengan PASI (p = 0.001 dan p = 0.000). Kadar visfatin serum dapat menjadi faktor prediktor tingkat keparahan psoriasis berdasarkan skor PASI.
Time to talk salt

Just over a decade ago, the BMJ found itself in the eye of the storm about dietary salt ( BMJ 1996;312:1239-40). We had published the Intersalt study some years previously; it concluded that populations with high average intakes of salt were likely to have higher average blood pressures. But the salt producers' trade organisation, the Salt Institute, had criticised the study's methods and asked the investigators to hand over their raw data for reanalysis. A reanalysis was done—by the original investigators—and published in the BMJ ( BMJ 1996;312:1249-53). The findings were the same. It's worth remembering this skirmish in the war on dietary …
Perceval Sutureless valves in isolated and concomitant AVR procedures: an economic model shows overall decrease of costs for isolated or combined operations

BACKGROUND: aortic valve replacement (AVR) the most common heart valve operation, accounts for a majority of all valve surgery performed in the elderly. The Perceval S (P) is a new aortic valve which is implanted without suturing, which causes a significant reduction in cross-clamping times (CCTs), and makes valve implantation easier and faster thanks to its collapsed profile. These features potentially allow the pool of operable patients to be expanded, even with minimally invasive surgery in isolated AVRs. AIM: to predict costs and outcomes of AVR procedures associated with this new valve in 4 European countries (Italy, France, Germany, and UK), as compared to traditional (T) valve implants, from the cost perspective of the hospital. METHOD: a probabilistic, patient-level simulation model was fully coded in WinBugs, permitting a seamless integration of parameter estimation and outcomes prediction, which was entirely based on the associated CCTs and on the surgical technique (mini-invasive [MiS] vs. full sternotomy [FS]), through published correlations. Unit cost were retrieved from official and literature sources for all countries. Besides the incorporated probabilistic sensitivity analysis, a series of deterministic sensitivity analyses was performed. RESULTS: the model predicts the use of the Perceval S valve to be associated with less complications and with savings (valve cost excluded), mainly related to a reduction in surgery costs and ICU/hospital bed days. These savings range from € 3,600 (Italy) to £ 3,900 (UK) for PFS in isolated AVRs and from about € 6,000 (Italy) to £ 6,700 (UK) for PMiS in isolated AVRs, and for PFS in concomitants. Extensive sensitivity analyses confirm the robustness of such findings. CONCLUSIONS: the results of the present analysis indicate that the hospital acquisition cost difference between the new sutureless Perceval S valve and traditional valves is offset by important savings in other cost items.
A Study of Computer Phobia among Prospective Teachers

Computer technology has revolutionized the Indian educational system. The main goal of computer in education is to enhance the teaching – learning process, but computer phobia is one of the major obstacles. In the present study, the researchers have made an attempt to find out computer phobia among the prospective teachers and also suggested some measures to remove this phobia among prospective teachers.
The Value of the Macronucleolus in the Cancer Problem

In the early nineties of the last century I began to learn the wisdom of that dictum of Louis Agassiz, “Study nature, not books. ” It was about that time that systematic and dogmatic science was being added to by efforts to observe nature rather than to make nature conform to bookish authority. This period also marked the beginning of operative surgery, which later offered some of us an opportunity to see human tissues as they exist during life rather than at the autopsy. Early experience with the oil-immersion lens in the study of bacteria and other forms of microscopic lower life, as well as the finer structure of plants and insects, developed a habit apparently unknown to morbid anatomists studying human tissues. There are some definite reasons for the failure of these latter to use the oil lens: Post-mortem changes in cells and artefacts produced by fixation, embedding and staining served to obscure and destroy the finer cellular structures which have become so obvious with the study of fresh unfixed and unembedded tissues during life.
Adrenalina inhalatoria en el tratamiento de la bronquiolitis: ¿son suficientes las evidencias disponibles para recomendar su utilización?

RESUMEN Introducción: la bronquiolitis constituye un problema de salud importante. Su tratamiento es de sostén. Los agonistas 2 adrenérgicos no han demostrado afectar la evolución de la enfermedad. En los últimos años, el uso de adrenalina aumentó considerablemente en el tratamiento de la bronquiolitis en nuestro medio. Objetivo: analizar la evidencia disponible sobre eficacia y seguridad del tratamiento con adrenalina inhalatoria en pacientes con bronquiolitis. Metodología: se identificaron en Medline los ensayos clínicos controlados (ECC), metaanálisis y revisiones sistemáticas publicados entre 1995 y 2006, que compararon la eficacia de la adrenalina con placebo o con salbutamol. Se definió bronquilitis como el primer episodio de sibilancias en el curso de una infección respiratoria en menores de 24 meses. Se evaluaron los efectos sobre saturación de oxígeno de la hemoglobina, prevención de la hospitalización, duración de la estadía hospitalaria, asistencia ventilatoria y mortalidad. Resultados: se identificaron 17 estudios; 11 cumplieron con los criterios de inclusión (nueve ensayos clínicos, un metaanálisis y una revisión sistemática). No se identificaron estudios que evalúen la eficacia de adrenalina sobre la necesidad de asistencia ventilatoria mecánica y mortalidad. En los estudios disponibles no se observaron efectos beneficiosos de la adrenalina sobre la necesidad de hospitalización, la duración de la estadía hospitalaria ni la saturación de oxígeno de la hemoglobina. Los efectos adversos más frecuentemente observados fueron palidez facial, taquicardia y temblor. Conclusiones: la evidencia disponible no permitió observar un claro beneficio del tratamiento con adrenalina en pacientes con bronquiolitis. No hubo diferencias significativas en la saturación de oxígeno, necesidad de hospitalización ni duración de la estadía hospitalaria. Los efectos adversos hallados fueron leves. Por el momento no existen evidencias que permitan recomendar el uso de adrenalina inhalatoria en el tratamiento de la bronquiolitis.
Perzeptive Evaluation transauraler Binauralsynthese unter Berücksichtigung des Wiedergaberaums

Copyright applies. A non-exclusive, non-transferable and limited right to use is granted. This document is intended solely for personal, non-commercial use. Terms of Use Schlenstedt, Gunar; Brinkmann, Fabian; Pelzer, Sönke; Weinzierl, Stefan (2016): Perzeptive Evaluation transauraler Binauralsynthese unter Berücksichtigung des Wiedergaberaums. In: Proceedings of the InterNoise 2016 : 45th International Congress and Exposition on Noise Control Engineering : towards a quiter future : August 21-24, 2016, Hamburg. Berlin: Deutsche Gesellschaft für Akustik e.V. pp. 561–564. Gunar Schlenstedt, Fabian Brinkmann, Sönke Pelzer, Stefan Weinzierl