Miracle-dz/UniFAR-FTUs huggingface dataset:
Repeat abortions--why more?

This article challenges the theory that a high repeat abortion rate in the United States is evidence that the legalization of abortion has led couples to relax contraceptive efforts and rely on abortion as a primary method of birth control. Statistics collected in New York City and 12 states in 1974-1976 and demonstrably representative of the nation as a whole show that repeat abortions have almost doubled and that the repeat abortion rate is much higher than the first abortion rate. The increase in the number of repeat abortions can be explained by the increase in the number of women who have had 1st abortions. The higher risk of repeat abortions can be explained by several factors: As a group women with abortion experience are generally older more sexually active and more fecund than the group of women who have never had an abortion. Furthermore women who have once chosen an abortion can be expected to chose to terminate a future pregnancy while the group of women who have never had an abortion includes a substantial number who would never choose abortion to end an unintended pregnancy. Only a few women find abortion easier as a means of birth control than consistent contraception. Hence a repeat abortion rate that is higher than a first abortion rate is to be expected regardless of contraceptive practice.
An Efficient Object Classification Based On ELM

An Efficient Object Classification Based On ELM ment--> ������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:. 0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} Abstract: The combination of the digital and genomic revolutions with health, health care, living and society is called as Digital Health. As we know, the technology is growing rapidly day by day, now a day we are using technology in medical fields too. We can use our mobile phone as our personal doctor. There are many mobile applications used for “health app”. These health apps are growing rapidly but still we expect more in future. The health apps is used for improving the patient care and makes medical activities reliable. In these applications the patient can diagnosis his/her disease and treatment recommendation are reported. Since these health apps are the bridge between the consumers and clinicians, through which patient can diagnosis his/her disease even at home. So we have to know how these apps works. There are many apps created for the Mobile phones. We will discuss one of the health app i.e. M-health application. This paper captures the working of M-health app.
Arguments for the sake of endophenotypes: Examining common misconceptions about the use of endophenotypes in psychiatric genetics

Endophenotypes are measurable biomarkers that are correlated with an illness, at least in part, because of shared underlying genetic influences. Endophenotypes may improve our power to detect genes influencing risk of illness by being genetically simpler, closer to the level of gene action, and with larger genetic effect sizes or by providing added statistical power through their ability to quantitatively rank people within diagnostic categories. Furthermore, they also provide insight into the mechanisms underlying illness and will be valuable in developing biologically‐based nosologies, through efforts such as RDoC, that seek to explain both the heterogeneity within current diagnostic categories and the overlapping clinical features between them. While neuroimaging, electrophysiological, and cognitive measures are currently most used in psychiatric genetic studies, researchers currently are attempting to identify candidate endophenotypes that are less genetically complex and potentially closer to the level of gene action, such as transcriptomic and proteomic phenotypes. Sifting through tens of thousands of such measures requires automated, high‐throughput ways of assessing, and ranking potential endophenotypes, such as the Endophenotype Ranking Value. However, despite the potential utility of endophenotypes for gene characterization and discovery, there is considerable resistance to endophenotypic approaches in psychiatry. In this review, we address and clarify some of the common issues associated with the usage of endophenotypes in the psychiatric genetics community. © 2014 Wiley Periodicals, Inc.
Prevalence of antibodies in human sera against JC virus, an isolate from a case of progressive multifocal leukoencephalopathy.

JC virus is a papova-like virus that was isolated recently from the brain tissue of a patient with progressive multifocal leukoencephalopathy (PML) [1]. Our initial studies indicated that JC virus is a new virus that probably belongs in the polyoma-SV40 subgroup of papova viruses. PML is a rare demyelinating disease that usually occurs in people with an immunologic deficiency due to a preexisting chronic disease [2]. It is not known whether such people are more easily infected or whether a latent virus becomes activated in such cases. The finding that JC virus agglutinates human type O erythrocytes permitted the rapid assaying of human sera for antibodies against this virus. The results presented here give an indication of the incidence of infection by JC virus.
Preserving Global and Local Features - a Combined Approach for Recognizing Face Images

Face recognition technologies can significantly impact authentication, monitoring and image indexing applications. Much research has been done on face recognition using global and local features over the last decade. By using global feature preservation techniques like Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA), we can effectively preserve only the Euclidean structure of face space, that are devoid of the lack of local features which may play a major role in some applications. On the other hand, the local feature preservation technique namely Locality Preserving Projections (LPP) preserves local information and obtains a face subspace that best detects the essential face manifold structure; however, it also suffers loss in global features which could be important in some of the applications. In this work, a new combined approach for recognizing faces which preserve both global and local information has been introduced. The proposed technique generates Combined Global and Local Preserving Features (CGLPF) that integrates the advantages of the global feature extraction technique LDA and the local feature extraction technique LPP. He et al. in their work used PCA to extract similarity features from a given set of images in order to reduce the dimensions followed by LPP. But in our method, we use LDA (instead of PCA) to extract discriminating features to reduce the dimension that yields improved facial image recognition results. This has been verified by making a fair comparison of the above two methods by the use of ORL, UMIST and 600 images formed by combining both databases.
Fluorescent Speckle Microscopy (FSM) of Microtubules and Actin in Living Cells

Fluorescent speckle microscopy (FSM), a combination of conventional wide‐field fluorescent light microscopy and digital imaging with a low‐noise, charge‐coupled device (CCD) camera, has been developed to allow visualization of assembly/disassembly dynamics, movement, and turnover of macromolecule assemblies in vivo and in vitro. FSM uses a low level of fluorescent subunits to avoid high background. This produces an image of speckled molecules that co‐assemble with endogenous molecules and are followed to characterize dynamic events in living cells.
Leveraging DNA repair deficiency in gynecologic oncology

Purpose of review The review discusses DNA repair deficiencies in ovarian cancer and how this has become the target for poly (ADP-ribose) polymerase (PARP) inhibition as a successful therapeutic strategy. Recent findings Hereditary ovarian cancers arise from germline mutations in BRCA1, BRCA2, or other important genes in the DNA repair process of homologous recombination. Sporadic ovarian cancers can also acquire a phenotype of homologous recombination deficiency through various other mechanisms. Recent studies have found the class of drugs called PARP inhibitors to selectively target ovarian cancers with homologous recombination deficiency. There are eight PARP inhibitors in various phases of clinical development with four being actively studied in phase III trials in ovarian cancer. In December 2014, the first-in-human PARP inhibitor olaparib was approved for ovarian cancer patients with two different clinical indications in Europe and the United States. Summary Ovarian cancer has become a model for the successful translation of targeted therapy against DNA repair deficiencies in cancer.
Voltage-dependent conformational changes of KVAP S4 segment in bacterial membrane environment

The nature and magnitude of voltage sensor conformational changes during ion channel activation are controversial. We have analyzed the topology of the KVAP voltage sensor domain in the absence and presence of a hyperpolarized voltage using native, right-side out membrane vesicles from E. coli. This approach does not disrupt the normal membrane environment of the channel protein and does not involve detergent solubilization. We found that voltage-dependent conformational changes are focused in the N-terminal half of the KVAP S4 segment, in excellent agreement with results obtained with Shaker. Homologous residues in the KVAP and Shaker S4 segments are transferred from the extracellular to the intracellular compartment upon hyperpolarization. Taken together with X-ray structures indicating that the KVAP S4 segment is outwardly displaced at 0 mV compared to S4 in a mammalian Shaker channel, our results are consistent with the idea that S4 moves further during voltage-dependent activation in KVAP than in Shaker.
Information attribute motivators of personal health information management activities

Understanding the motivating factors for personal health information management (PHIM) activities can inform the design of interventions to help people engage in healthful PHIM activities. This paper examines the attributes of health information that can motivate people's PHIM activities. We explored this topic through a qualitative study using semi‐structured one‐on‐one interviews with 47 American and Chinese patients living with type 1 or type 2 diabetes. We found 10 information attribute motivators, including the availability, abundance, credibility, accuracy, consistency, timeliness, usefulness, process level, and presentation style of, as well as the emotions elicited by, health information objects. Those motivators tell rich and complex stories of how health information is appreciated and handled on a daily basis by patients living with different health conditions or from different social contexts. Many of the motivators have not been examined in detail in the literature, pointing to the importance and necessity of involving them when designing interventions to improve health care outcomes through motivating PHIM activities.
c-Src is activated by the epidermal growth factor receptor in a pathway that mediates JNK and ERK activation by gonadotropin-releasing hormone in COS7 cells.

Sarah Kraus, Outhiriaradjou Benard, Zvi Naor, and Rony Seger This article has been withdrawn by the authors. Lanes 1–4 and lanes 7–10 of the G-JNK immunoblot in Fig. 1B were duplicated. In Fig. 2A, the DP-JNK immunoblots on the leftwere inappropriately manipulated. In Fig. 2A, the G-JNK immunoblots in the middle row were duplicated. In Fig. 3B, lanes 2 and 7 of the phosphorylated MBP panel were duplicated. In Fig. 5A, lane 1 of the Ras-GTP panel was inappropriately manipulated. Lanes 7 and 11 were duplicated. Because the original data are no longer available, in the interest of maintaining accuracy in the published scientific literature, the authors wish to withdraw this article. However, the authors have full confidence in the findings and conclusions of this paper. WITHDRAWALS/RETRACTIONS
Rapid switches in subpolar North Atlantic hydrography and climate during the Last Interglacial (MIS 5e)

plateauing just below early MIS 5e values. A planktonic d 18 O minimum during the cooling event indicates that marked freshening of the surface waters accompanied the cooling. We suggest that switches in the subpolar gyre hydrography occurred during a warmer climate, involving regional changes in freshwater fluxes/balance and East Greenland Current influence in the study area. The nature of these hydrographic transitions suggests that they are most likely related to large-scale circulation dynamics, potentially amplified by GIS meltwater influences.
Increased pain tolerance as an indicator of return to work in low-back injuries after work hardening.

OBJECTIVE This study examined retrospective data from a multidisciplinary work-hardening program that compared patients who did and did not return to work after low-back injury. The objective of this study was to identify differences between these groups to better guide work-hardening programs and return-to-work decisions. METHOD Retrospective data from patients with low-back injuries (n = 115) who participated in a northern California work-hardening program were analyzed. Using two-way analysis of variance, male and female patients who did and did not return to work were compared. RESULTS No significant differences were found between men and women for any of the variables studied. Patients who did and did not return to work were not significantly different in age, length of injury, and subjective pain at the beginning or end of the work-hardening program or in activity tolerance (p = .08). Patients who returned to work perceived a significantly (p < or = . 05) greater improvement in pain tolerance by the end of the work-hardening program than those who did not return to work. CONCLUSION The results of this study suggest that rehabilitation emphasis should not be placed on the reduction of subjective pain but, rather, on strategies to cope with existing pain while improving functional ability.
STUDIES ON THE PHOTOPROTECTIVE MECHANISM OF BUTYLATED HYDROXYTOLUENE

Abstract It has been suggested that butylated hydroxytoluene (BHT) ‡ , a phenolic antioxidant that conveys photoprotective properties to skin, may act by altering epidermal parameters that influence the level of ultraviolet light (UV) reaching critical target sites. The potential diminution of effective UV dose could account for the observed inhibition of UV‐induced ornithine decarboxylase (ODC). Thus studies were conducted to examine the possibility that BHT was capable of promoting epidermal proliferation, just as others have shown with lung epithelial cells. UV‐induction of ODC, in unrestrained Skh‐Hr‐I mice irradiated with Westinghouse FS–20 lamps, was shown to be linearly responsive from 0.3 to 0.6, J/cm2/dose. The degree of inhibition afforded by dietary BHT was approximately constant over this dose range. In addition, intraperitoneal administration of BHT (400 mg/kg) inhibited UV‐induced ODC as greatly as when provided dietarily. Greatest inhibition occurred when BHT was administered at least 46 h prior to UV exposure, with the inhibitory event(s) requiring over 20 h to become effective. However, BHT had no effect, during this time interval, upon the incorporation of [3H]thymidine or leucine into DNA and protein, respectively. Nor were BHT effects reflected in the epidermal labeling index. These data suggest that BHT does not induce epidermal proliferation. An alternate explanation, in which the antioxidant properties of BHT play a major role, is proposed.
Standards defining a 'Heart Valve Centre': ESC Working Group on Valvular Heart Disease and European Association for Cardiothoracic Surgery Viewpoint.

The increasing number of patients with heart valve disease and the wider range of therapeutic options now available, demands the standardization of organizational structures. The ‘heart valve clinic’ is already established as a specialist outpatient clinic linked with multidisciplinary inpatient care as well as education and training. Recent international guidelines extend this specialist concept to a ‘Heart Valve Centre of Excellence’ or ‘Heart Valve Centre’. These centres were proposed in order that durable mitral valve repair could be virtually guaranteed at close to zero risk in patients with asymptomatic severe mitral regurgitation caused by prolapse. The intention was that invasive valve interventions should not occur outside Heart Valve Centres. The standards defining such a centre have not previously been described and this is the purpose of this document. A Heart Valve Centre includes a heart valve clinic, but also multidisciplinary heart teams for the care of patients with mitral valve disease, tricuspid valve disease, diseases of the aorta and aortic valve and infective endocarditis (Table 1). [. ]
Effect of Direct Whole-Body Vibration on Upper-Body Muscular Power in Recreational, Resistance-Trained Men

Abstract Jones, MT, Martin, JR, Jagim, AR, and Oliver, JM. Effect of direct whole-body vibration on upper-body muscular power in recreational, resistance-trained men. J Strength Cond Res 31(5): 1371–1377, 2017—To determine the acute effect of whole-body vibration (WBV) on upper-body power, 15 men (mean ± SD; age 21.5 ± 2.3 years; height 173.1 ± 6.5 cm; and weight 77.2 ± 13.8 kg) with ≥1-year resistance training experience and a bench press (BP): body mass ratio ≥1.25 participated in a repeated-measures crossover design. Session 1 included body composition ([Bod Pod] 15.76 ± 6.7% body fat), 3 repetition maximum BP, and familiarization with: seated medicine ball throw (SMBT), plyometric push-up (PPU) on a force plate, and vertical WBV platform. Sessions 2–5 were randomly ordered across condition and test, separated by 24 hours, and consisted of a warm-up followed by 4 × 30-second push-up holds (2 × elbows at 90° and 2 × arms extended) performed on the vibration platform with WBV (frequency: 30 Hz, amplitude: 2–4 mm, 1:1 work: relief ratio) or no WBV. Seated medicine ball throw and PPU were tested immediately, 1, 5, and 10 minutes post. Standardized magnitude-based inferences were used to define outcomes. A likely positive effect of WBV was observed for SMBT at 10 minutes post. A likely negative effect of WBV resulted at 1 minute in time-to-peak force. A possibly positive effect was observed 10 minutes post. A possibly negative effect was observed 10 minutes post for peak power, and a likely negative effect of WBV was observed on time-to-peak power immediate post. Incorporating a 10-minute rest period is recommended when implementing power exercises after upper-body static-hold exercises during WBV exposure.
Prazosin reduces alcohol drinking throughout prolonged treatment and blocks the initiation of drinking in rats selectively bred for high alcohol intake.

BACKGROUND This study examined whether prazosin reduces alcohol drinking over the course of prolonged treatment and whether it blocks the initiation of alcohol drinking in rats with a genetic predisposition toward high alcohol drinking, that is alcohol-preferring (P) rats. METHODS In study one, alcohol-experienced P rats that had been drinking alcohol for 2 h/d for several months were treated daily with prazosin (0, 0.5, 1.0, or 2.0 mg/kg body weight [BW]) for 7 weeks. In study two, alcohol-naïve P rats were treated daily with prazosin (0, 1.0, or 2.0 mg/kg BW) for 2 weeks prior to, or concomitantly with, the initiation of alcohol access and throughout 3 weeks of alcohol availability. Prazosin treatment and alcohol access were then discontinued for 2 weeks followed by reinstatement of alcohol access without prazosin treatment for 4 weeks, followed by resumption of daily prazosin treatment (2.0 mg/kg BW) for 3 weeks. RESULTS Prazosin reduced alcohol drinking throughout 7 weeks of treatment in P rats accustomed to drinking alcohol. Following termination of prazosin treatment, alcohol drinking slowly returned to pretreatment baseline. Reduced alcohol intake was accompanied by increased water intake. In alcohol-naïve P rats, prazosin administration prior to the first opportunity to drink alcohol and throughout 3 weeks of alcohol access retarded acquisition of alcohol drinking and reduced the amount of alcohol consumed. When prazosin was administered concomitantly with the first opportunity to drink alcohol, it abolished acquisition of alcohol drinking. Discontinuation of prazosin treatment allowed expression of a genetic predisposition toward high alcohol drinking to gradually emerge. Prazosin retained the ability to reduce alcohol intake with repeated treatments. CONCLUSIONS Prazosin decreased alcohol drinking during prolonged treatment and may be useful for treating alcoholism and alcohol-use disorders. Prazosin may also be useful for deterring the initiation of drinking in individuals with a family history of alcoholism.
THE EFFECT OF VARIATION OF NEUROMUSCULOSKELETAL MODEL CONTROL PARAMETERS ON PERFORMANCE DURING SIMULATED HUMAN WALKING

The sensitivity of the walking performance of an established neuromusculoskeletal model to four major parameter groups was assessed to evaluate its robustness and response characteristics. Variables from the sensory system, the neural interconnectivity, the movement generator, and the postural controller groups were individually varied and the simulations rerun for each case. The range over which the parameters were varied was dictated by when the model could no longer walk. Overall, the model was robust in that it could walk over moderate to relatively large ranges of changes in each parameter group. The model was least sensitive to changes in the sensory parameters, exhibiting stable walking over a range of –30% to + 82% of the baseline value. It showed a large range for the neural interconnectivity and postural controller variables. It showed stable walking for the smallest range, -10% to +20% for the rhythmic or movement controller variable. Continued testing will further elucidate the characteristics of the model responses and its similarity to that of a human. Intersegmental dynamics (or “induced acceleration”) analysis will be used to assess how the model performance strategy differs from that of normal human walking. This may also be used to refine how the model responds.
Immunocytochemical staining for CEA in small cell carcinoma of lung predicts clinical usefulness of the plasma assay

Recent studies have shown plasma CEA levels are useful in both staging and monitoring response to treatment in patients with small cell cancer of the lung (SCCL). CEA elevations do not occur in all patients however, and have been of less value in patients with limited disease. Immunoperoxidase staining for CEA performed on tumor tissue from 48 patients (17 extensive, 31 limited disease) with SCCL revealed: (1) A strong correlation between positive CEA tissue staining and plasma CEA elevation. Plasma CEA elevations occurred in 18/21 CEA tissue positive patients and correlated with the clinical course in all 18. In contrast elevated plasma CEAs were seen in only 3/27 CEA tissue negative patients; (2) CEA tissue positive patients had a higher incidence of extensive disease (62% versus 18%) and a higher incidence of liver metastases (43% versus 7%); and (3) No correlation between histologic subtype and CEA tissue staining was apparent. Cancer 52:301‐306, 1983.