Miracle-dz/UniFAR-FTUs huggingface dataset:
An TRIM59‐CDK6 axis regulates growth and metastasis of lung cancer

Lung cancer (LC) is a devastating malignancy with no effective treatments, due to its complex genomic profile. Using bioinformatics analysis and immunohistochemical of lung carcinoma tissues, we show that TRIM59 as a critical oncoprotein relating to LC proliferation and metastasis. In this study, high TRIM59 expression was significantly correlated with lymph node metastasis, distant metastasis, and tumour stage. Furthermore, up‐regulation of TRIM59 expression correlated with poorer outcomes in LC patients. Mechanistically, TRIM59 play a key role in promoting LC growth and metastasis through regulation of extracellular‐signal regulated protein kinase (ERK) signalling pathway and epithelial‐to‐mesenchymal transition (EMT)‐markers, as validated by loss‐of‐function studies. In‐depth bioinformatics analysis showed that there is preliminary evidence of co‐expression of TRIM59 and cyclin dependent kinase 6 (CDK6) in LC. Notably, CDK6 expression significantly decreased when TRIM59 was knocked down in the LC cells. In contrast, exogenous up‐regulation of TRIM59 expression also induced significant increases in the expression of CDK6. Moreover, the expression of CDK6 was also inhibited by the ERK signalling inhibitor, U0126. The results of both loss‐ and gain‐of‐function studies showed that TRIM59 could regulate the expression of CDK6. Collectively, these data provide evidence that TRIM59 is involved in lung carcinoma growth and progression possibly through the induction of CDK6 expression and EMT process by activation of ERK pathway.
Privacy theory in practice: designing a user interface for managing location privacy on mobile devices

ABSTRACT Disclosing the current location of a person can seriously affect their privacy, but many apps request location information to provide location-based services. Simultaneously, these apps provide only crude controls for location privacy settings (sharing all or nothing). There is an ongoing discussion about rights of users regarding their location privacy (e.g. in the context of the General Data Protection Regulation – GDPR). GDPR requires data collectors to notify users about data collection and to provide them with opt-out options. To address these requirements, we propose a set of user interface (UI) controls for fine-grained management of location privacy settings based on privacy theory (Westin), privacy by design principles and general UI design principles. The UI notifies users about the state of location data sharing and provides controls for adjusting location sharing preferences. It addresses three key issues: whom to share location with, when to share it, and where to share it. Results of a user study (N=23) indicate that (1) the proposed interface led to a greater sense of control, that (2) it was usable and well received, and that (3) participants were keen on using it in real life. Our findings can inform the development of interfaces to manage location privacy.
PARENCHYMAL CELLS FROM ADULT RAT LIVER IN NONPROLIFERATING MONOLAYER CULTURE

Parenchymal cells from adult rat liver have been established in primary monolayer culture. Donor animals are subjected to a partial hepatectomy and, 4 days later, cells are prepared by collagenase perfusion of the regenerated liver. The hepatic parenchymal cells, separated from nonparenchymal material and suspended in serum-free medium, are placed in plastic tissue culture dishes, where they form a monolayer within 24 h. The monolayer cells exhibit minimal mitotic activity and demonstrate several major metabolic functions characteristic of liver in vivo; these include albumin synthesis and secretion, gluconeogenesis from 3-carbon precursors, responsiveness to insulin and glucagon, glycogen synthesis, and activity of two microsomal enzymes. These functions are present in the monolayer cells for several days at activities similar to those observed in the liver in vivo. The findings indicate that hepatic parenchymal cells in this monolayer system are viable and behave in many respects like normal adult rat liver.
Synthesis of ZnO nanoparticles and their antibacterial effects

The zinc oxide nanoparticles with the average particle size of about 30 nm were synthesized by the chemical technique and their properties were studied with the help of scanning electron microscope and X-ray diffraction. The aim of this study was to detect the antibacterial properties of 0.01, 0.5 and 1% nano-ZnO against Escherichia coli . E. coli was cultured in liquid and agar nutrient medium to evaluate the antibacterial effects of 0.01, 0.05 and 1% of ZnO via the optical density (OD) and log CFU/ml measurements. Non-significant effect was seen for 0.01% of ZnO nano-particles, while 0.05 and 1% of nanoparticles showed considerably decreased bacterial number. A 4.385 and 2.04 times decrease in the OD value was found in the presence of 1 and 0.5% nano-ZnO, respectively (P<0.001) as compared to the control. In the second study, 6.3 log CFU/ml of E. coli were present in the cultures treated with 1% nano-ZnO at 4°C in water. Control E. coli cells survived for 12 days, while complete cell death was seen when 1% nano-ZnO was applied for 24 h. In the third study, E. coli was grown in the agar medium with and without nanoparticles and suppressed growth (8.56 times; P<0.001) was seen in the presence of 1% nano-ZnO. Keywords: ZnO-nanoparticle, antibacterial, bactericidal, Escherichia coli
A Research on the Determination of Machiavellian Personality Tendencies

In this study, firstly, the concept of Machiavellianism is expressed. Secondly, the issue of high and low Machiavellian personality is discussed. Thirdly, it is investigated that if 370 university students’ demographic characteristics majoring at Trakya University Faculty of Economics and Administrative Sciences will influence Machiavellian personality tendencies. The main objective of this study is to determine whether or not Machiavellian personality tendencies show differences in participants’ demographic characteristics. The Mach IV scale was used to measure the tendency to be Machiavellian. Frequency analysis, factor analysis, Kolmogorov-Smirnov normality test, Mann-Whitney U and Kruskal-Wallis tests were carried out. The results of the study showed that the dimension of Unethical Behavior, a sub-dimension of Machiavellian personality tendencies, showed differences according to gender.
A new precision measurement of the anomalous magnetic moment of the positive muon

The muon anomalous magnetic moment has been measured in a new experiment at Brookhaven. Polarized muons were stored in a superferric ring, and the angular frequency difference, {omega}{sub a} , between the spin precession and orbital frequencies was determined by measuring the time distribution of high-energy decay positrons. The ratio R of {omega}{sub a} to the Larmor precession frequency of free protons, {omega}{sub p} , in the storage-ring magnetic field was measured. We find R=3.707thinsp220(48){times}10{sup {minus}3} . With {mu}{sub {mu}}/{mu}{sub p}=3.183thinsp 345thinsp47(47) this gives a{sub {mu}{sup +}}=1thinsp165thinsp 925(15){times}10{sup {minus}9} ({plus_minus}13 ppm ), in good agreement with the previous CERN measurements for {mu}{sup +} and {mu}{sup {minus}} and of approximately the same precision. {copyright} {ital 1999} {ital The American Physical Society}
GOVERNMENTAL ADMINISTRATION AND EUROPEAN UNION: STRATEGIC CHALLENGES FACED BY EUROPEAN MEMBER STATES OF 2004 AND 2007 ENLARGEMENT

1) and two countries of the 2007 enlargement (i. e. Bulgaria and Rumania), their membership in the European Union have effected in serious political, legal and institutional tensions and challenges. An important area where these challenges can be perceived and subjected to research is their governmental administration. At this level, new tasks have emerged and the old ones have changed significantly reflecting completely new administrative reality - at least to the extent to which national administration of a member states is exposed to European Union law and governance. This article is to investigate the new challenges and requirements as they can be perceived and addressed by Eastern European EU member states. Its objective is also to identify the core European competences these states should have developed or, if necessary acquired, in order to become credible, effective, and efficient partners to the «old» member states in the field of European integration.
INFLUENCE OF PARASITIC CAPACITANCES ON THE POWER OUTPUT OF ELECTRET-BASED ENERGY HARVESTING GENERATORS

The power output of electrostatic energy harvesting generators is usually predicted using a widely accepted formulation derived by Boland et al. in 2003. However, this model neglects the effects caused by parallel parasitic capacitances, namely those built into the device itself and those introduced by the measurement setup. Even if such capacitances are in the pF range, they can cause a substantial power loss and the generator power cannot be realiably predicted. This paper describes the derivation and experimental validation of an extended analytical model, that takes parasitic capacitances into account.
Imprints of the quasar structure in time-delay light curves: Microlensing-aided reverberation mapping

Owing to the advent of large area photometric surveys, the possibility to use broad band photometric data, instead of spectra, to measure the size of the broad line region of active galactic nuclei, has raised a large interest. We describe here a new method using time-delay lensed quasars where one or several images are affected by microlensing due to stars in the lensing galaxy. Because microlensing decreases (or increases) the flux of the continuum compared to the broad line region, it changes the contrast between these two emission components. We show that this effect can be used to effectively disentangle the intrinsic variability of those two regions, offering the opportunity to perform reverberation mapping based on single band photometric data. Based on simulated light curves generated using a damped random walk model of quasar variability, we show that measurement of the size of the broad line region can be achieved using this method, provided one spectrum has been obtained independently during the monitoring. This method is complementary to photometric reverberation mapping and could also be extended to multi-band data. Because the effect described above produces a variability pattern in difference light curves between pairs of lensed images which is correlated with the time-lagged continuum variability, it can potentially produce systematic errors in measurement of time delays between pairs of lensed images. Simple simulations indicate that time-delay measurement techniques which use a sufficiently flexible model for the extrinsic variability are not affected by this effect and produce accurate time delays.
Weak Iron Oxidation by Sulfobacillus thermosulfidooxidans Maintains a Favorable Redox Potential for Chalcopyrite Bioleaching

Bioleaching is an emerging technology, describing the microbially assisted dissolution of sulfidic ores that provides a more environmentally friendly alternative to many traditional metal extraction methods, such as roasting or smelting. Industrial interest is steadily increasing and today, circa 15–20% of the world’s copper production can be traced back to this method. However, bioleaching of the world’s most abundant copper mineral chalcopyrite suffers from low dissolution rates, often attributed to passivating layers, which need to be overcome to use this technology to its full potential. To prevent these passivating layers from forming, leaching needs to occur at a low oxidation/reduction potential (ORP), but chemical redox control in bioleaching heaps is difficult and costly. As an alternative, selected weak iron-oxidizers could be employed that are incapable of scavenging exceedingly low concentrations of iron and therefore, raise the ORP just above the onset of bioleaching, but not high enough to allow for the occurrence of passivation. In this study, we report that microbial iron oxidation by Sulfobacillus thermosulfidooxidans meets these specifications. Chalcopyrite concentrate bioleaching experiments with S. thermosulfidooxidans as the sole iron oxidizer exhibited significantly lower redox potentials and higher release of copper compared to communities containing the strong iron oxidizer Leptospirillum ferriphilum. Transcriptomic response to single and co-culture of these two iron oxidizers was studied and revealed a greatly decreased number of mRNA transcripts ascribed to iron oxidation in S. thermosulfidooxidans when cultured in the presence of L. ferriphilum. This allowed for the identification of genes potentially responsible for S. thermosulfidooxidans’ weaker iron oxidation to be studied in the future, as well as underlined the need for new mechanisms to control the microbial population in bioleaching heaps.
Experimental investigation of the hydrodynamic performance of the ISWEC 1:20 scaled device

An experimental campaign test has performed on the 1:20 scaled moored model of ISWEC (Inertial Sea Wave Energy Converter). The annual productivity of the device is strictly correlated to the hydrodynamic properties of the floater. Therefore, is fundamental to carry out an experimental investigation of the hydrodynamic performance of the floater and compare the results with the numerical codes. In this paper the experimental campaign is described. Two different mooring configurations were tested to understand the different influence of mooring forces on the floater dynamics. The non-dimensional Response Amplitude Operator (RAO) is representative of the hydrodynamic performances of the floater. Therefore, the device with both the mooring configurations has been tested in regular waves of constant wave steepness 1/50. Conclusions are commenting the differences a between numerical and experimental results and the impact of nonlinearities on hydrodynamic performances.
Development of Community Participation in Somaliland: Implications of International Solidarity Foundation’s Development Co-operation in Somaliland

Authors Title Number of Pages Date Nina Toija and Rauha Vesterinen Development of Community Participation in Somaliland: Implications of International Solidarity Foundation’s Development Co-operation in Somaliland 38 + 3 appendices Autumn 2015 Degree Bachelor of Social Services Degree Programme Degree Programme in Social Services Specialisation option Degree Programme in Social Services Instructor(s) Mai Salmenkangas, Senior Lecturer International Solidarity Foundation (ISF) is a Finnish development co-operation organization, which aims at promoting gender equality, creating sustainable and decent work and livelihood, and strengthening civil societies. These aims are aligned with the policies of the Finnish development co-operation. The objective of this study was to explore how the work ISF and their partner organizations have done in Somaliland has enhanced participation in the local communities. The perspective for this study is derived from the viewpoints of the land co-ordinator of ISF and representatives of their partner organizations in Somaliland. The conclusions from this study were used as a background analysis for ISF’s upcoming action plan for the years 2016-2018. The approach in this study was qualitative. Computer mediated communication was employed for the collection of data. The questionnaire was sent to representatives of ISF’s partner organizations, and ten responses were received. In addition to this, the land coordinator for ISF in Somaliland was interviewed via Skype. The Ladder of Citizen Participation (Arnstein) and the Power Cube (Gaventa), which examine interactional citizen participation and the dimensions of power, formed the theoretical framework for the study. The data obtained for this study showed that the presence of ISF and their partner organizations has affected the levels of citizen participation, especially that of women. New forms of participation have opened up democratic decision making fora that strengthen citizenship and self-determination in the communities the projects were implemented in. Based on the results, ISF’s community based approach has had the desired effect on many levels during co-operation with their partner organizations. Participation and gender equality have increased, as have the possibilities of community members to affect their own living environment. Nonetheless, it seems that project operations could be clarified and the recommendations of representatives of partner organizations could be recognized to a greater extent.
The Effectiveness of Exercise Therapy in Reducing Pain and Improving Clinical Outcomes in Rotator Cuff Tendinopathy : a Systematic Review

A systematic review of randomized controlled trials (RCTs) was performed to examine the effectiveness of exercise interventions in treating patients with rotator cuff tendinopathy. Three databases were searchedMedline OvidSP, CINAHL, and EMBASE. Ten articles examining eight different RCTs were reviewed. The clinical outcomes examined were shoulder pain, strength, range of motion, quality of life, and function. The secondary objective was to determine which parameters of exercise are most beneficial in treating this group of conditions. A qualitative data analysis was performed. Although few conclusive statements can be made, the evidence suggests that exercise interventions can lead to improvements in all of the abovementioned clinical outcomes. Specific shoulder exercises appear to be more effective than general, non-specific neck and upper extremity exercises. Additionally, exercises performed at a higher intensity may be more beneficial than those performed at a lower intensity. The exercise parameters used in the studies vary considerably, and therefore it is difficult to draw conclusions about the most beneficial exercise prescription. Further research is needed in order to conclusively determine the effectiveness of exercise interventions in the treatment of rotator cuff tendinopathy. The Effectiveness of Exercise Therapy in Reducing Pain and Improving Clinical Outcomes in Rotator Cuff TendinopathyA Systematic Review 2
meta4diag: Bayesian Bivariate Meta-analysis of Diagnostic Test Studies for Routine Practice

This paper introduces the \proglang{R} package \pkg{meta4diag} for implementing Bayesian bivariate meta-analyses of diagnostic test studies. Our package \pkg{meta4diag} is a purpose-built front end of the \proglang{R} package \pkg{INLA}. While \pkg{INLA} offers full Bayesian inference for the large set of latent Gaussian models using integrated nested Laplace approximations, \pkg{meta4diag} extracts the features needed for bivariate meta-analysis and presents them in an intuitive way. It allows the user a straightforward model-specification and offers user-specific prior distributions. Further, the newly proposed penalised complexity prior framework is supported, which builds on prior intuitions about the behaviours of the variance and correlation parameters. Accurate posterior marginal distributions for sensitivity and specificity as well as all hyperparameters, and covariates are directly obtained without Markov chain Monte Carlo sampling. Further, univariate estimates of interest, such as odds ratios, as well as the SROC curve and other common graphics are directly available for interpretation. An interactive graphical user interface provides the user with the full functionality of the package without requiring any \proglang{R} programming. The package is available through CRAN \url{this https URL} and its usage will be illustrated using three real data examples.
Long Term Evolution (LTE) Network Evaluation in the South-West Region of Nigeria

The LTE broadband evolved from an earlier Third Generation Partnership Project system which is known as the Universal Mobile Telecommunication System (UMTS), which evolved from the Global System for Mobile Communications (GSM). The network architecture of this system has been designed with the aim to support a packet-switched traffic with seamless mobility and great quality of service. The main goal of the LTE is to provide a high data rate with low latency and a packet optimized radio access technology that supports deployment of bandwidth. Hence, this study is based on the evaluation of the LTE network in the south-west region of Nigeria. This study evaluates the LTE network strength in the South-West region of Nigeria. Questionnaires were administered among users in these areas randomly. Thereafter, data were analyzed and research questions were answered from the analyzed results. The results showed that 9Mobile and MTN has the best quality of service of LTE network in South-West, Nigeria, also that the LTE network has not really been active in Osun and Ekiti states.
Mortality and morbidity rounds (MMR) in pathology: relative contribution of cognitive bias vs. systems failures to diagnostic error

Abstract Background Heuristics and cognitive biases are thought to play an important role in diagnostic medical error. How to systematically determine and capture these kinds of errors remains unclear. Morbidity and mortality rounds (MMRs) are generally focused on reducing medical error by identifying and correcting systems failures. However, they may also provide an educational platform for recognizing and raising awareness on cognitive errors. Methods A total of 49 MMR cases spanning the period 2008–2015 in our pathology department were examined for the presence of cognitive errors and/or systems failures by eight study participant raters who were trained on a subset of 16 of these MMR cases (excluded from the main study analysis) to identify such errors. The Delphi method was used to obtain group consensus on error classification on the remaining 33 study cases. Cases with <75% inter-rater agreement were subjected to subsequent rounds of Delphi analysis. Inter-rater agreement at each round was determined by Fleiss’ kappa values. Results Thirty-six percent of the cases presented at our pathology MMRs over an 8-year period were found to contain errors likely due to cognitive bias. Conclusions These data suggest that the errors identified in our pathology MMRs represent not only systems failures but may also be composed of a significant proportion of cognitive errors. Teaching trainees and health professionals to correctly identify different types of cognitive errors may present an opportunity for quality improvement interventions in the interests of patient safety.
The influence on goodwill impairment: the factors behind the tool. A comparative research in the EU

This study investigates what factors influence the use of goodwill impairment. Using a sample of 1.262 firm year observations, two aspects of goodwill impairment are examined. A pooled logit corrected for clusters is used to determine which factors influence the decision to impair goodwill. An OLS analysis looks at the effects of the factors on the magnitude of the impairments. In total seven factors are examined for these two effects. Three factors on a firm level: big bath strategy, smoothing strategy and the level of leverage of a firm. Furthermore, the effect of industry is examined, while on a country level once more three factors are under investigation: the strength of capital markets, national enforcement and national culture using the six dimensions of Hofstede. The big bath strategy, like size of the firm, has a significant positive effect on the use of goodwill impairment, while smoothing and operating in the financials and the consumer discretionary, consumer staples and health care industry indicate an opposite effect. Furthermore, indications are found that also leverage, the strength of capital markets, national enforcement and some cultural aspects have an effect on if and how much goodwill firms are willing to impair.