Miracle-dz/UniFAR-FTUs huggingface dataset:
INFLUÊNCIA DA MALTODEXTRINA SOBRE A GLICEMIA E O RENDIMENTO DE ATLETAS JUVENIS DE BASQUETEBOL

O objetivo deste estudo foi avaliar a influencia da ingestao da maltodextrina 6% sobre o desempenho, percepcao do esforco e variacao na glicemia em atletas juvenis de basquetebol. Participaram do mesmo 7 atletas (15,85 ± 0,89 anos). Foi utilizado o teste de 12 minutos. Foram coletadas amostras de sangue para dosagem da glicose. Os resultados demonstram que a ingestao do suplemento nao interferiu no rendimento das atletas; Promoveu uma pequena elevacao na glicemia 20min. apos sua ingestao e uma reducao significativa, logo apos o exercicio. A percepcao de esforco nao sofreu influencia da suplementacao. Conclui-se, que a bebida contendo carboidrato nao foi capaz de melhorar o desempenho, manter a glicemia e nem amenizar a sensacao de cansaco. O objetivo deste estudo foi avaliar a influencia da ingestao da maltodextrina 6% sobre o desempenho, percepcao do esforco e variacao na glicemia em atletas juvenis de basquetebol. Participaram do mesmo 7 atletas (15,85 ± 0,89 anos). Foi utilizado o teste de 12 minutos. Foram coletadas amostras de sangue para dosagem da glicose. Os resultados demonstram que a ingestao do suplemento nao interferiu no rendimento das atletas; Promoveu uma pequena elevacao na glicemia 20min. apos sua ingestao e uma reducao significativa, logo apos o exercicio. A percepcao de esforco nao sofreu influencia da suplementacao. Conclui-se, que a bebida contendo carboidrato nao foi capaz de melhorar o desempenho, manter a glicemia e nem amenizar a sensacao de cansaco. Ouvir Ler foneticamente
Photon-assisted tunneling through a quantum dot.

We study single-electron tunneling in a two-junction device in the presence of microwave radiation. We introduce a model for numerical simulations that extends the Tien-Gordon theory for photon-assisted tunneling to encompass correlated single-electron tunneling. We predict sharp current jumps which reflect the discrete photon energy [ital hf], and a zero-bias current whose sign changes when an electron is added to the central island of the device. Measurements on split-gate quantum dots show microwave-induced features that are in good agreement with the model.
Cancer Patients’ Perceptions of the Barriers and Facilitators to Patient Participation in Symptom Management During an Episode of Admission

Background: Symptoms by definition are subjective, and patients’ role in their assessment and management will impact on patient outcomes; thus, symptom management is an area of acute care practice where facilitation of patient participation is vital if quality outcomes are to be achieved. Objective: This study originated from a large multimethod research program exploring patient participation in symptom management in an acute oncology setting. The purpose of this article is to explore patients’ perceptions of the barriers and facilitators to participating in their symptom management during an episode of admission to an acute oncology ward and the relationships between these perceptions and patients’ preference for participation. Methods: One hundred seventy-one cancer inpatients consented and completed an interview-administered questionnaire. Patients’ preference for participation was measured using the Control Preference Scale. Responses to open-ended survey questions were evaluated using content analysis. Results: Ten categories were identified in the analyses of patient perceptions of the barriers and facilitators to participating in care decisions relating to their symptoms. Patients, irrespective of their Control Preference, reported multiple barriers and facilitators to participating in their symptom management. Conclusions: Patients overall perceived information as the most critical component of participation. Irrespective of patients’ preference for participation, there were similarities in the barriers and facilitators to the operationalization of participation in the acute care setting reported. Implications for Practice: Understanding patient perceptions of barriers and facilitators of participating in symptom management has provided important insights into person and system factors in the acute care sector impacting quality patient symptom outcomes.
Polymorphisms in the IBD5 Locus Are Associated With Crohn Disease in Pediatric Ashkenazi Jewish Patients

Objectives: To analyze the IBD5 locus in a homogenous cohort of Ashkenazi Jewish (AJ) children with Crohn disease (CD). Patients and Methods: A total of 83 AJ children with CD and 73 AJ healthy controls were studied. Genotyping for single nucleotide polymorphisms (SNPs) including OCTN1 (SLC22A4; 1672C→T), OCTN2 (SLC22A5; 207G→C), IGR2096, IGR2198, and IGR2230 genes was performed using the TaqMan system. NOD2/CARD15 variants also were typed using established methods. Results: All IBD5 SNPs tested were in linkage disequilibrium (D′>0.8), and showed significant association with CD in our cohort of AJ children. The IGR2096 SNP, which is not located within the same linkage disequilibrium block as the OCTN1 and 2 SNPs, showed an even stronger association with CD (P = 0.017; odds ratio = 1.7). Patients with CD who had the OCTN1 susceptibility allele were more likely to carry 1 of the 3 NOD2/CARD15 SNPs tested (P = 0.01; odds ratio = 4.8). Conclusions: We have demonstrated a significant association between the IBD5 locus and CD in a homogenous cohort of pediatric AJ patients. Due to the tight linkage disequilibrium in the region, it is not possible to identify the causative IBD5 variant. Future functional studies will ultimately reveal the causative gene variant at this locus.
Utility of Clinical Features for the Diagnosis of Seizures in the Intensive Care Unit

Purpose: Seizures in the intensive care unit are often subtle, and may have little or no clinical correlate. This study attempts to determine what clinical features are most strongly associated with the presence of electrographic seizures on continuous EEG (cEEG) monitoring. Methods: A retrospective review for all patients who underwent cEEG monitoring between January 2003 and March 2009 for either characterization of clinical events or altered mental status was performed. Clinical events were categorized as (1) limb myoclonus/tremor, (2) extremity weakness, (3) eye movement abnormalities, (4) facial/periorbital twitching, and (5) other abnormal movements. The presence of associated dyscognitive event features was also recorded. Results: Records from 626 patients who underwent cEEG were reviewed—154 for event characterization and 472 for altered mental status. Seizures were captured in 48 patients (31.2%) undergoing cEEG monitoring for characterization of clinical events. This was not significantly different from the incidence of seizures in patients undergoing cEEG for altered mental status (N = 133, 28.2%). Patients undergoing cEEG monitoring for facial/periorbital twitching were significantly more likely to have electrographic seizures (78.9%, P < 0.005) than patients undergoing cEEG for altered mental status or characterization of other types of events. Conclusions: The incidence of seizures in patients in the intensive care unit with clinical events is generally not significantly higher than the incidence of seizures in patients in the intensive care unit with altered mental status. However, the presence of facial/periorbital twitching was associated a higher incidence of electrographic seizures.
Hypersensitivity associated with sugammadex administration: a systematic review

Sugammadex is a drug used to reverse neuromuscular blockade induced by rocuronium or vecuronium. It has not yet been approved by the Food and Drug Administration in the USA due to concerns regarding hypersensitivity. The objective of this review was to identify similarities in the presentation of hypersensitivity reactions to sugammadex. A comprehensive search was performed in PubMed, Scopus and Web of Science for cases reporting hypersensitivity reactions to sugammadex. In addition, we contacted regulatory agencies and the company marketing the drug for unpublished reports. Reports were included if they were in English, primary investigations, lacked an alternative probable explanation for the reaction and included a comprehensive description of the hypersensitivity. We identified 15 cases of hypersensitivity following sugammadex administration. All cases that reported exact timing (14/15) occurred in 4 min or less. Most of the patients (11/15; 73%) met World Anaphylaxis Organization criteria for anaphylaxis. Awareness must be raised for the possibility of drug‐induced hypersensitivity during the critical 5‐min period immediately following sugammadex administration.
Dorsomedial hypothalamic nucleus neurons integrate important peripheral feeding‐related signals in rats

Several studies have implicated the dorsomedial hypothalamic nucleus (DMN) in regulation of feeding behavior and body weight, but clear mechanisms by which it controls food intake are not well understood. We report the results of the present study, which showed that the DMN receives important peripheral short‐ and long‐term feeding‐related afferent signals, including gastric vagal, glycemia, and cholecystokinin (CCK) inputs, as well as from leptin, an adipostatic signal that forcefully inhibits food intake and increases metabolic rate. Among the 279 DMN neurons recorded, 173 (62.0%) responded to stimulation of gastric vagal nerves. Also, of the 123 DMN neurons responsive to gastric vagal stimulation that were tested with the administration of intravenous glucose, 75 (61.0%) were identified as being glycemia sensitive. Moreover, it is noteworthy that of the 23 DMN neurons that responded to both gastric vagal and intravenous glucose stimulation, most (19 of 23, 82.6%) were sensitive to circulating leptin, and some neurons (n = 7) were also responsive to systemic CCK, suggesting that gastric vagal, glycemic, CCK, and leptin inputs converge on single DMN neurons. Furthermore, synergistic interactions between leptin and glucose on single DMN neurons were observed (n = 6). These results demonstrate that those important peripheral feeding‐related gastric vagal, glycemic, CCK and leptin signals not only reach the DMN but also interact on single DMN neurons, suggesting that the DMN may not just function as a relay station, but independently integrate the short‐term and long‐term feeding‐associated information and actively participate in the direct regulation of feeding behavior. © 2007 Wiley‐Liss, Inc.
Explaining the Howiesons Poort to post-Howiesons Poort transition: a review of demographic and foraging adaptation models

The Howiesons Poort technocomplex exhibits archaeological evidence for sophisticated, ‘modern’ behaviour. Indications of such behaviour are less conspicuous in Middle Stone Age deposits post-dating the Howiesons Poort. Different explanations for the apparent technological regression have been put forward. This paper reviews interpretations proposing that demographic developments and behavioural ecological adaptations across the transition from the Howiesons Poort to the post-Howiesons Poort caused changes in human behaviour. It suggests that the available evidence does not support dramatic demographic developments. A more parsimonious explanation involves the combined effects of changing resource availability and changing mobility strategies.
Clinical and magnetic resonance imaging in optic neuritis

We found 23 of 48 patients (48%) with isolated monosymptomatic optic neuritis (ON) to have 1 to several brain lesions by MRI. All the brain lesions were clinically silent and had characteristics consistent with multiple sclerosis (MS). During 4 years of follow-up, 9 patients (19%) developed definite MS on clinical grounds. Six of the converting patients had abnormal MRIs; the other 3 had MRIs that were normal both initially (when they had ON only) and when repeated after they had developed MS. The other 17 patients with abnormal MRIs have not developed symptoms or signs of MS during follow-up. Thus, an abnormal MRI does not auger development of clinical MS within a mean of 4 years, nor does a normal MRI protect against development of disseminated disease. It is not prudent to give a patient with isolated monosymptomatic ON the diagnosis of MS (probable or definite) because of an abnormal MRI (with or without other laboratory abnormalities).
Stem cell options for kidney disease

Chronic kidney disease (CKD) is increasing at the rate of 6–8% per annum in the US alone. At present, dialysis and transplantation remain the only treatment options. However, there is hope that stem cells and regenerative medicine may provide additional regenerative options for kidney disease. Such new treatments might involve induction of repair using endogenous or exogenous stem cells or the reprogramming of the organ to reinitiate development. This review addresses the current state of understanding with respect to the ability of non‐renal stem cell sources to influence renal repair, the existence of endogenous renal stem cells and the biology of normal renal repair in response to damage. It also examines the remaining challenges and asks the question of whether there is one solution for all forms of renal disease. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Finding the Smallest Ellipse Containing a Point Set based on Genetic Algorithms

Finding one of the smallest non-standard ellipse containing a given point set, is very useful in image and picture labeling. The paper presents an approach to seek the ellipse. The paper was not going to seek the equation of the ellipse, it solved the 5 elliptical parameters (the long axis a, the short axis b, the elliptical center and the rotation k) for determining the ellipse, instead. In order to reduce the problem complexity, the search of non-standard ellipse was turned into the standard ellipse's search through spatial coordinate transformation. And the genetic algorithms are adopted to optimize the ultimate aim to solve the smallest non-standard ellipse. The experiment results show that the approach is effective.
Crowdsourcing participativo institucional. Información geográfica voluntaria en la administración pública. Ejemplos

Se defiende y argumenta que las entidades publicas, tales como administraciones locales, organismos y empresas publicas, fundaciones, etc., estan realizando determinadas actividades equivalentes a la VGI, a traves de las cuales reunen y comparten nuevos datos e informacion geografica entre ellos y con la comunidad. Y lo hacen, mayoritariamente, por la intervencion e iniciativa de algunos de sus miembros, que desde su rol de funcionarios de dichas entidades participan en el mismo esfuerzo de cooperacion y contribuyen con la creacion, gestion y publicacion de informacion que, en rigor, no pertenece a las tareas asignadas o responsabilidades de dichas entidades publicas. El articulo presenta algunas experiencias en el marco de la IDE (Infraestructura de Datos Espaciales) catalana que demuestran claramente la importancia creciente de este tipo de voluntariado «publico» dentro del paradigma VGI y sus beneficios para las administraciones publicas y los ciudadanos
Repair of skull defects with autogenous bone.

Twenty-two major skull reconstructions were done using autogenous rib or iliac bone. When bone from the rib was used, it was split and wired in place over a bony lip formed at the edge of the defect. Iliac crest was fitted as a keystone in an arch and fastened with wire. Functional results were perfect in all but two cases, and aesthetic results excellent in all but two. In each case, the unsatisfactory results were directly due to inattention to operative detail. There were no losses of grafts, and no significant infections. Autogenous bone to reconstruct the calvarium gives excellent aesthetic and functional results when the technique described is followed.
Reversal of Tetracycline Resistance Mediated by Different Bacterial Tetracycline Resistance Determinants by an Inhibitor of the Tet(B) Antiport Protein

ABSTRACT Active efflux is a useful strategy by which bacteria evade growth inhibition by antibiotics. Certain semisynthetic tetracycline (TC) analogs, substituted at the 13th carbon at C-6 on ring C of the TC molecule, blocked TC efflux as revealed in everted membrane vesicles from class B TC-resistant (Tcr) Escherichia coli (M. L. Nelson, B. H. Park, J. S. Andrews, V. A. Georgian, R. C. Thomas, and S. B. Levy, J. Med. Chem. 36:370–377, 1993). A representative C-13-substituted analog, 13-cyclopentylthio-5-OH-TC (13-CPTC), was shown to competitively inhibit TC translocation by the Tet(B) protein, blocking the uptake of TC into vesicles and therefore the efflux of TC from whole cells. Against TcrE. coli, 13-CPTC, when used in combination with doxycycline, produced synergistic inhibition of growth. 13-CPTC was shown to increase the uptake of [3H]TC into the resistant cells. 13-CPTC alone was a potent growth inhibitor against TC-susceptible (Tcs) and TcrStaphylococcus aureus and enterococci specifying class K or class L efflux-dependent TC resistance mechanisms or, unexpectedly, the class M ribosomal protection mechanism. These findings indicate that derivatives of TC, identified by their ability to block the Tet(B) efflux protein, can restore TC activity against Tcr bacteria bearing either of the two known resistance mechanisms. Blocking drug efflux and increasing intracellular drug concentrations constitute an effective approach to reversing TC resistance and may be generally applicable to other antibiotics rendered ineffective by efflux proteins.
Initiation of replication of the human hepatitis delta virus genome from cloned DNA: role of delta antigen

Beginning with three partial cDNA clones of the RNA genome of human hepatitis delta virus (HDV), we assembled the complete 1,679-base sequence on a single molecule and then inserted a trimer of this into plasmid pSLV, a simian virus 40-based eucaryotic expression vector. This construct was used to transfect both monkey kidney (COS7) and human hepatocellular carcinoma (HuH7) cell lines. In this way we obtained replication of the HDV RNA genome and the appearance, in the nucleoli, of the delta antigen, the only known virus-coded protein. This proved both that the HDV genome could replicate in nonliver as well as liver cells and that there was no requirement for the presence of hepatitis B virus sequences or proteins. When the pSVL construct was made with a dimer of an HDV sequence with a 2-base-pair deletion in the open reading frame, genome replication was reduced at least 40-fold. However, when we cotransfected with a plasmid that expressed the correct delta antigen, the mutated dimer achieved a level of genome replication comparable to that of the nonmutated sequence. We thus conclude that the delta antigen can act in trans and is essential for replication of the HDV genome.
Preferences for touch gestures in audio-tactile communication

People use different touch gestures in everyday life to interact with each other. However, remote communication typically supports only auditory and visual modalities. Gestures such as squeezing, stroking and patting could be used for supporting emotional communication between remote users. In this paper we study how different touch gestures are used as a part of audio communication. A user study was conducted where participant pairs were provided with hand-held devices that converted squeeze and finger touch gestures to vibrotactile stimulation. When one participant touched the device, another participant felt the touch simultaneously on a second device. The participants' task was to use the devices during conversations that varied in their emotional topics. The results of touch use analysis showed that the participants spent more time interacting via squeeze. Also, male participants rated squeeze as more suitable than finger touch. The emotional conversation topic did not have an effect on the use of touch gestures. In discussion the current findings are compared to prior research where only the tactile modality was used.
A study on business and technology strategy in achieving business objectives.

In today’s fast-paced and rapidly changing business environment, companies has deeply modified their strategies to integrate technology into the business planning process. Technologies are now everywhere in the firm’s value chain. Thus, it is necessary for firms to adapt their strategic process as technology is pervasively important as part of business function. This implies the need to study a technology strategy that link technology with business objective. In this paper, the researchers will review a structured approach to business and technology strategy. The process includes study a framework that serve as a guidance to organizations enabling them to analyse the technology needs for a business. Therefore, managers must be aware of the strategic importance of technology in delivering value and competitive advantage to their companies. Among the awareness are deciding which technologies support the strategic objectives, identifying companies strengths and weaknesses, establishing technology priorities, and finally deciding strategic actions.
Involvement of the cerebellar thalamus in human saccade adaptation

Saccade adaptation can be experimentally induced by systematically displacing a visual cue during a targeting saccade. Non‐human primate studies have highlighted the crucial role of the cerebellum for saccade adaptation, but its neural substrates in humans are poorly understood. Recent physiological experiments suggest that, in addition to cerebellar structures, cortical areas may be involved as well. We have therefore hypothesized that saccade adaptation may rely on a cerebello‐cerebral network, in which the cerebellar thalamus may link cerebellar and cerebral structures. To test this hypothesis, we studied saccade adaptation in a group of four patients with a thalamic lesion, with (n = 2) or without (n = 2) involvement of the cerebellar thalamus. Compared to healthy subjects, saccade adaptation was reduced in patients with associated cerebellar syndrome, but normal in patients without cerebellar syndrome. These results are consistent with the hypothesis that cerebello‐thalamic pathways contribute to saccade adaptation in humans and suggest that the thalamus relays adaptation‐related information from the cerebellum to cerebral cortical oculomotor areas.