Miracle-dz/UniFAR-FTUs huggingface dataset:
Applied Research into Amino Acid Nutrition

Studies over the last 2 decades clearly established the link between nutrition and fertility in ruminants (Robinson et al., 2006; Wiltbank et al., 2006; Grummer et al., 2010; Santos et al., 2010; Cardoso et al., 2013; Drackley and Cardoso, 2014). Dietary changes can cause an immediate and rapid alteration in a range of humoral factors that can alter endocrine and metabolic signaling pathways crucial for reproductive function (Boland et al., 2001; Diskin et al., 2003). Moreover, periconceptional nutritional environment in humans and other animals is critical for the long-term setting of postnatal phenotype (Fleming et al., 2015). Restricting the supply of B-vitamins and methionine during the periconceptional period in sheep, e.g., resulted in adverse cardiometabolic health in postnatal offspring (Sinclair et al., 2007). Feeding female mice a low-protein diet during the preimplantation period of pregnancy resulted in a reduction in amino acid (AA) concentration in uterine fluid and serum and attendant changes in the AA profile of the blastocyst (Eckert et al., 2012).
Effects of manipulating resistance-training program variables on muscle performance

The purpose of'this investigation was to examine the effects of multiple-set isokinetic concentric exercise on rnuscle strength performdnce using various rest protocols. Physically active college rnales (n=28) were asked tb attend four testing sessions consisting of fouf sets of LO maximal v6luntary contractions (MVCs) of the guadr'iceps and hamstrings muscle groups at movement vel6cities of 6Oo/s and LSOo/s. The rest periods between sets for this study were 30, 60, LzO, and 240 seconds (s). A Biodex System 2 isokinetic dynamom'eter was used to rneasure peak torgue (Pf) and total work (TW) during each tria}. Two-way (4 x 4) ANOVAs with two repeated measures and Tukey post-hoc analyses were used to find that performance at 6Oo/s demonstrated significant differences between the short (30 s and 60 s) and long (l2O s and 24O s) rest conditions at sets 2, 3, and 4. The only significant difference between the 30 s and 60 s rest conditions vras seen in set 3 and set 4 for quadriceps TW. Hamstrings and guadriceps PT at 6Oo/s. declined t-5.82 and 8.8? , respectively, from set L to set 4 during the 30 s rest protocol. At the same velocity and rest
Robust recognition of strongly distorted speech

The automatic speech recognition systems have become a part of our daily lives. People often rely on virtual personal assistants in smartphones, use their voice to control intelligent devices in cars and smart homes or communicate with automatic dialogue systems in call-centres. Since these systems often suffer from a performance drop in realistic acoustic conditions which are characterized by strong distortions, a large portion of research still must be focused on robust front-end algorithms and acoustic modelling methods for distorted speech recognition. This thesis is focused on these compensation methods working at the level of front-end processing and acoustic modelling, whose aim is to compensate the degradation introduced by a distant microphone, noisy environments and a lossy compression. The techniques for noisy and distant speech recognition studied in this thesis were focused on front-end noise suppression techniques, feature normalization techniques, acoustic model adaptations and discriminative training. Said techniques were evaluated in three different car conditions and two different public environments. The experiments have proved, that extended spectral subtraction can bring significant improvement even for the state-of-the-art systems in public environments with a strong noise and for a far-distance microphone recordings. The evaluation of compressed speech recognition examined the degrading effects of lossy compression on fundamental frequency, formants and smoothed LPC spectrum and for standard MFCC and PLP features used for ASR. The low-pass filtering and the areas of very low energy in a spectrogram were identified as the two main reasons of degradation. The practical experiments evaluated the contributions of specific feature extraction setups, combinations of normalization and compensation techniques, supervised and unsupervised adaptation and discriminative training methods and finally the matched training. The largest contributions were gained from the application of adaptation techniques, subspace GMM and discriminative training. A novel algorithm named Spectrally selective dithering (SSD) was proposed within this thesis, which compensated the effect of spectral valleys. The contribution of said algorithm was verified for both GMM-HMM and DNN-HMM speech recognition systems for Czech and English and for a GMM-HMM system for German. The practical experiments proved that the proposed algorithm can lower WER for all languages with GMM-HMM systems. Concerning DNN-HMM system, a significant contribution was achieved only for Czech.
Nuovi anticoagulanti orali: considerazioni di farmacologia clinica

Oral anticoagulant therapy is widely used to prevent and treat thromboembolic events. Traditionally, warfarin has been the drug of choice providing a significant reduction in stroke risk in patients with atrial fibrillation. However, warfarin has several drawbacks, such as a delayed onset of anticoagulant action, a narrow therapeutic index, an unpredictable and variable response. The new oral anticoagulants (NOACs), dabigatran (a reversible direct thrombin inhibitor) and the direct factor Xa inhibitors rivaroxaban, apixaban and edoxaban offer fixed dosing, more predictable pharmacokinetics and fewer interactions with drugs and food. Moreover, these drugs seem to provide an improved benefit-risk ratio with respect to thromboembolic events and bleeding complications in a broad patient population. However, significant differences between the four NOACs in terms of pharmacokinetic and safety profile are observed and must be considered to personalize the therapy based on the pathophysiological conditions of the patient. In the present review the pharmacological characteristics of NOACs in relationship to their safety and efficacy profiles will be discussed.
The use and effectiveness of system development methodologies in mobile application development

Syntax Notation – ASN Agile System Development Methodology – ASDM Information Technology – IT Message Sequence Charts – MSC Mobile Application Development – MAD Mobile Application Development Methodology – MADM Specification and Description Language – SDL Structured analysis, design, and implementation of information systems –STRADIS System Development Life Cycle – SDLC System Development Methodology – SDM Tree and Tabular Combined Notation – TTCN
Focal Cerebral Ischemia in Rats: Effect of Hemodilution with α-α Cross-Linked Hemoglobin on Brain Injury and Edema

ABSTRACT: The effect of hemodilution, with α-α cross-linked hemoglobin (DCLHb), on brain injury and edema was assessed after temporary middle cerebral artery occlusion in rats. Injury was analyzed with 2,3,5-triphenyltetrazolium chloride (TTC) stain and edema by microgravimety. Part A: DCLHb was given to maintain one of the following hematocrits (Hct) and normotension: 1) 45/Hct, 2) 30/Hct, 3) 16/Hct, or 4) 9/Hct. Brain injury (% of ischemic hemisphere, mean ± SD) was less in the 30/Hct group (31 ±4) versus the 45/Hct group (42 ± 5); and in the 16/Hct (20 ± 3) and 9/Hct (19 ± 4) groups versus the 45/Hct and 30/Hct groups. Edema was less in the hemodiluted groups versus the 45/Hct group. Part B: DCLHb was given to maintain one of the following hematocrits and hyper (HTN) − or normotension (Norm): 1) 45/Norm, 2) 30/Norm, 3) 30/HTN, 4) 16/Norm, or 5) 16/HTN. In hematocrit matched groups hypertension decreased brain injury (30/HTN − 24 ± 2 < 30/Norm − 34 ± 4; and 16/HTN − 17 ± 3 < 16/Norm − 24 ± 4). Edema was not effected by hypertension. These results suggest that hemodilution with DCLHb decreases focal ischemic injury, and is most effective when given in a manner that induces hypertension.
Genital skin diseases and their expression in sexual functionality

Sexual functionality acts as an important function of the individual, acting both physically and mentally to create a state of well-being and permitting procreation. A large number of mucosal and cutaneous ailments may affect the genial areas in both males and females, generally leading to local symptoms that impede the sexual act. Genital diseases, sometimes even without impairing the sexual function, may still alter the dynamics just because of the enormous psychological impact that occurs in these situations. We aim to review main dermatological disorders that alter normal function of the genitalia, as well as their physical mechanism by which the sexual functionality is changed.
Immunization of ovarian cancer patients with an NY-ESO-1 peptide of dual MHC class I and II specificities plus incomplete Freund adjuvant induces simultaneous humoral, CD4+ and CD8+ T-cell responses

5040 Background: NY-ESO-1 is a highly immunogenic “cancer-testis” antigen expressed in epithelial ovarian cancer (EOC). The NY-ESO-1 peptide epitope, ESO:157–170, is recognized by HLA-DP4 restricted CD4+ T cells, and HLA-A2 and A24 restricted CD8+ T cells. To test whether providing cognate helper CD4+ T cells would enhance the anti-tumor immune response, we conducted a phase I clinical trial of immunization with ESO:157–170 plus incomplete Freund’s adjuvant (Montanide ISA51). Methods: Eighteen HLA-DP4-positive EOC patients who had no evidence of disease, or minimal residual disease, following chemotherapy for primary or recurrent disease were enrolled. Tumor expression of NY-ESO-1 was determined by RT-PCR and immunohistochemistry. Patients were immunized with 100 μg of ESO:157–170, mixed with Montanide, every 3 weeks for a minimum of 5 injections, or up to 15 injections, or until disease progression. Immune responses were measured by DTH, ELISA, tetramer, and IFN-γ ELISPOT assays. Results: There were no v.
Multi-floor Mapping and Navigation with Uncertainty

This paper outlines the research using autonomous robots conducted by a group of undergraduate engineering students from the University of St. Thomas. The students were able to develop a mutli-floor mapping and navigation system that allowed a robot, named Turtlebot, to give nearly autonomous tours of their multi-floor engineering building. The Turtlebot can effectively traverse the hallways, use the elevator, and play audio files during tours.
Bronquiolitis: artículo de revisión

La bronquiolitis, es una enfermedad frecuente en la infancia y constituye la principal causa de ingreso hospitalario en los menores de 2 años, por infección del tracto respiratorio inferior (ITRI). Se caracteriza por síntomas respi­ratorios superiores que conducen a síntomas respiratorios inferiores por la infección primaria o la reinfección con un patógeno viral, el más identificado es el virus respiratorio sincicial (VRS). A pesar de la frecuencia e importancia de esta enfermedad, aún existen grandes controversias en cuanto al protocolo terapéutico más adecuado. Su definición y tratamiento siguen siendo tema de constantes debates y motivo de estudio, buscando llegar a un consenso mundial sobre el adecuado abordaje de esta entidad, por lo que este artículo es un enfoque práctico de la bronquiolitis, basado en la evidencia científica disponible en cuanto a la epidemiología, manifestaciones clí­nicas, diagnóstico, tratamiento y prevención de la bronquiolitis. La implementación de un algoritmo terapéutico es factible y puede ayudar a reducir los errores de manejo y la tasa de prescripción de esteroides y antibióticos, inadecuados en niños con bronquiolitis.
Psychological and Pedagogical Support for High School Students’ Self-Reflection

Today it is essential to create conditions for reflective processes which facilitate self-realization among schoolchildren. Self-reflection is necessary for the development of high school students, since it is due to reflection that the attitude to oneself is revived, the need for self-change and self-development appear. The aim of the study was to identify and test the effectiveness of psychological and pedagogical support for reflection formation in high school students. Various theoretical and empirical methods of research were used; a psychological and pedagogical experiment was conducted by means of the following methods: “Self-Reflection and Insight Scale” (SRIS) developed by Grant, Franklin, & Langford (2002); Leontyev’s (2009) questionnaire “Differential Type of Reflection” (DTR) and Karpov’s (2003) questionnaire “Method of Reflexivity Diagnostics” (MRD). The article presents the results of experimental work on testing the effectiveness of the program to ensure the development of reflection among high school students. Experimental studies were carried out in secondary schools of the city of Kazan (Russian Federation). The results of the experimental study proved the effectiveness of psychological and pedagogical assistance in high school students’ self-reflection formation.
Standard chemotherapy (CMF or AC) versus capecitabine in early-stage breast cancer (BC) patients aged 65 and older: Results of CALGB/CTSU 49907

507 Background: Older women with BC are underrepresented in clinical trials. Scant data exist on the effects of adjuvant chemotherapy (CRx) in these patients (pts). CALGB/CTSU 49907 was designed to compare the efficacy of capecitabine (X) with standard treatment (S) in BC pts ≥ 65 yrs old. Methods: Pts were randomized to X or S (CMF or AC per physician choice). Eligibility: Stage T1–4, N0–3, M0; PS 0–2, ≤ 84 days from surgery; adequate organ function. Regimens (all doses per M2): CMF (C, 100 mg d1–14 oral; M 40 mg d1,8; FU 600 mg d1,8) q4wk×6 cycles; AC (A 60 mg; C 600 mg) q3wk×4; X (2,000 d1–14) q3wk×6. Endocrine therapy was recommended after completion of CRx for hormone receptor positive (HR+) pts. A Bayesian design addressed equivalence of X to S; total sample size planned 600–1,800 pts with serial monitoring. The primary endpoint was relapse-free survival (RFS) defined as locoregional or distant relapse or death. We calculate Bayesian measures, including the probability of inferiority of X (that the .
Clinical profile of patients presenting with acute coronary syndrome to the Ladysmith Provincial Hospital emergency department

ion  Data collection was initiated on 1 June 2013.  Eligible patients, meeting study criteria and who presented to the Ladysmith Provincial Hospital ED before 1 June 2013 at 00:00 were included in the study.  The researcher reviewed Ladysmith hospital ED registers.  The researcher also reviewed intensive care unit, high care ward and the medical ward registers to identify patients with ACS that were misdiagnosed in the ED and later diagnosed in these wards.  All the above registers had documented as standard hospital protocol, the final patient diagnoses before transfer out of the ED or before discharge from the ICU, high care ward and medical ward.  138 patients were required as per sample size calculation (see below).  A sample size of 160 patients was agreed upon to account for a possible 15% of medical records with incomplete data entry.
Physiotherapy Students Attitude towards Physiotherapist-Patient Relationship -

Background: The physician-patient relationship has been bedrock of care since all the times. This relationship is essential in the transference of health care facilities, treatment plans, diagnosis and improvement in the medical fields. Objectives: The objectives of the study are; to explain and quantify the attitudes of physiotherapy students, undergoing pre-clinical rotations, towards patient-centred approach and to measure the association/statistical significance in these attitudes and demographic data and to determine the factors associated with patient centered attitude. Methodology: This is an observational cross sectional study. It was done at department of physical therapy Azra Naheed Medical College, University of Lahore and School of Allied Health Sciences. Study was completed in 4 months after the approval of synopsis. Non-probability, purposive sampling was used. Sample size was calculated to be of 215 students. Self-administered questionnaire consisting of validated 18-items, Patient Practitioner Orientation Scale (PPOS) was used to find out the attitude of physiotherapy students towards physiotherapist-patient relationship. Results: The total mean score and standard deviation of all the 18- items of PPOS scale was 3.025 ± 0.46. The mean and standard deviation of sharing item was 3.08 ±0.62, while the mean and standard deviation for caring items appeared to be 2.94 ± 0.59. The range of total PPOS score was 3.42, maximum value being 4.68 and minimum 1.26. Females showed more patient centered approach with a value of 3.05 ± 0.55 than males (Mean ± SD=2.92 ± 0.45). The mean and standard deviation of family in medical profession for PPOS had almost same values. The gender*year interaction was not statistically significant because the P-value was greater than 0.05 (P-value=0.067). But the gender and year individually had statistically significant difference as the P-values of both variables were less than 0.05. Gender (p = 0.04) and year (p = 0.02). Conclusion: The total Patient Practitioner Orientation Scale (PPOS) mean was high for female gender and early years of medical school. This showed that the factors that were responsible for the patient-centered attitude of physiotherapy students, these were female gender and early years of medical school. Male gender was found to be associated with physiotherapist-centered approach irrespective of the year of medical school.
Tratamento do pé varo espástico da paralisia cerebral pela técnica da transferência do hemitendão do tibial posterior

No período de julho de 1990 a maio de 1996 foram tratados 35 pacientes (41 pés) portadores de paralisia cerebral espástica com deformidade em varo do pé mediante a transferênca do hemitendão do músculo tibial posterior para o fibular curto; em 22 pés houve a associação do alongamento do tendão de Aquiles. Vinte pacientes eram do sexo masculino e 15, do feminino. A idade média por ocasião da cirurgia foi de oito anos e sete meses. O tempo médio de seguimento foi de dois anos e sete meses. Os autores obtiveram 37 pés (31 pacientes, 90,24%) com resultado bom, três pés (três pacientes, 7,31%), regulares e um pé (um paciente, 2,43%), mau. A técnica proporciona resultados muito bons no tratamento da deformidade em varo da paralisia cerebral.
Tuberculosis treatment delay in adults and household transmission to children: a community-based study in a setting with high burden of tuberculosis and HIV

1 List of abbreviations.3 Part A: Protocol.4 Protocol synopsis.5 Background and Rationale.7 Hypotheses, Aims and Objectives.10 Methods.11 Population and sampling.12 Study procedures.14 Variables.17 Data capture and handling.17 Statistical analysis.18 Ethics.18 Logistics.19 References. 21 Part B: Literature Review.24 Introduction.25 Literature search strategy.27 Summary of literature.29 Delay in tuberculosis diagnosis and treatment.29 Risk factors for TB infection.32 Risk factors for TB disease.35 Influence of HIV on TB transmission in South Africa.37 Conclusions.38 References.44 Part C. Manuscript.52 Abstract.54. 54 Introduction.55 Methods.56 Study setting and design.56 Eligibility.57 Study measures.57 Data and statistical analysis.58 Results.59 Discussion.62 Conclusion.64 References.73 Appendices.76 Appendix A. Ethics committee approvals.77 Appendix B. Author Instructions for Manuscript Submission.80 Appendix C. Additional TST analysis results: univariate and multivariate analysis with analysis of possible mediation.87 Appendix D. Analysis of missing data: Mantoux TST multivariate logistic regression. 92 Appendix E. Model checking. 93 Appendix F. Secondary analysis 1: Interferon gamma release assays (IGRAs) analysis.96 Appendix G. Secondary analysis 2: Prevalent tuberculosis disease.102 Appendix H. Household clustering.106 Appendix I. Variables for analysis.107
A REVIEW OF RECENT TRENDS IN NON-INVASIVE INSULIN THERAPY FOR DIABETES MELLITUS

Diabetes mellitus is generally a chronic condition associated with abnormally high levels of sugar (glucose) in the blood. Insulin is used for treating diabetes particularly of type I DM and selectively of type II DM patients. Presently available methods of administration of insulin are insulin syringes, insulin infusion pumps, jet injectors, insulin pens and the traditionally used method of administration i.e.; subcutaneous route are of invasive in nature. In order to reduce the pain of the patients, several approaches of non-invasive delivery of insulin are being developed. The newer non-invasive methods available are inhaled insulin, oral insulin, buccal insulin and transdermal delivery of insulin. This paper reviews the recent developments in noninvasive delivery of insulin with their formulation aspects and their advantages over invasive delivery of insulin. (DM- DIABETES MELLITUS).
Relationship of Learning Environments to Students’ Interactive Behavior in a Project-Based English Course

A number of studies of Active Learning (AL) explained that AL provided collaborative learning for students. The authors of this study believe providing good learning environments for students is important in order to improve AL course. The aim of this study is to identify a way to utilize AL classrooms for English language teaching in higher education. To this end, we conducted a questionnaire survey for students in project-based English classes both in a regular classroom and in an AL classroom. A total of 81 students participated in the survey. The results indicated no systematic difference between the normal classroom and the AL classroom in terms of students’ perceived in-class behavior such as student-student interaction (normal classrooms, 2.92; AL classrooms, 3.06), student-teacher formal interaction (normal classrooms, 2.74; AL classrooms, 2.81), and student as teachers (normal classrooms, 2.70; AL classrooms, 2.67) on a four-point scale. This result may be due to the equivalence in basic classroom conditions other than AL elements, such as the number of students, the size of the classroom, and classroom capacity. We therefore argue that classroom characteristics other than AL elements should also be described in future AL classroom research.