Miracle-dz/UniFAR-FTUs huggingface dataset:
Disinhibition and expectancy in risk for alcohol use: comparing black and white college samples.

OBJECTIVE This study tested several predictions of the "acquired preparedness" model in both black and white samples of college students. The acquired preparedness model holds that trait disinhibition affects alcohol-related learning and, ultimately, alcohol use. This model maintains that the reward focus typical of disinhibited individuals increases the likelihood of forming overly positive expectancies about the effects of alcohol. Alcohol expectancy, then, acts as a mediator of the relationship of disinhibition and drinking behavior. METHOD Participants (N = 479, 341 women) were 279 white and 200 black college students. Self-reported alcohol expectancy, disinhibition and drinking behavior were assessed. Covariance structure analysis was used to test hypotheses separately for each sample, controlling for socioeconomic status. RESULTS Black participants scored significantly lower on disinhibition, expectancy and drinking. However, invariance testing indicated that the relationships between these variables were not different across groups. Results were consistent with the stated hypotheses in both samples--alcohol expectancy functioned as a mediator of the disinhibition-drinking relationship. Results did not differ across expectancy content. CONCLUSIONS These results provide support for the validity of the acquired preparedness model. Despite mean differences in risk and drinking levels between black and white samples, psychosocial learning appears to mediate the influence of disinhibition on drinking for both groups.
How do prolific inventors impact firm innovation in ICT: implications from patent co-inventing network

Prolific inventors not only own higher innovation productivity, but also impact other inventors through innovation networks. This paper contributes to existing literatures by differentiating prolific inventors from non-prolific inventors in the network context, and making an empirical analysis of the effect of prolific inventors. We use the patent filing data from the State Intellectual Property Office of China (SIPO) in investigating the effect of prolific inventors on firm innovation. We use the patents filed by 10 largest Information & Communication Technology firms during 1995–2010 and establish the innovation network with patent co-inventing data. The empirical result shows that prolific inventors positively impact their partners who used to co-invent at least one patent with them. Furthermore, prolific inventors positively impact inventors who do not have a close contact with them. The closer the inventors are to prolific inventors, the more patents they produce. Members are thereby more likely to gather around prolific inventors and formulate intensive clusters. In networks centered by prolific inventors, useful knowledge outweighs redundant knowledge, and high clustering that facilitates knowledge flow is proved to be beneficial; while in networks without prolific inventors, high clustering may not be beneficial as there are less inventors holding advanced knowledge. Policy implications are discussed at the end of this study.
Sequence Requirements for Neuropilin-2 Recognition by ST8SiaIV and Polysialylation of Its O-Glycans*

Polysialic acid is an oncofetal glycopolymer, added to the glycans of a small group of substrates, that controls cell adhesion and signaling. One of these substrates, neuropilin-2, is a VEGF and semaphorin co-receptor that is polysialylated on its O-glycans in mature dendritic cells and macrophages by the polysialyltransferase ST8SiaIV. To understand the biochemical basis of neuropilin-2 polysialylation, we created a series of domain swap chimeras with sequences from neuropilin-1, a protein for which polysialylation had not been previously reported. To our surprise, we found that membrane-associated neuropilin-1 is polysialylated at ∼50% of the level of neuropilin-2 but not polysialylated when it lacks its cytoplasmic tail and transmembrane region and is secreted from the cell. This was not the case for neuropilin-2, which is polysialylated when either membrane-associated or soluble. Evaluation of the soluble chimeric proteins demonstrated that the meprin A5 antigen-μ tyrosine phosphatase (MAM) domain and the O-glycan-containing linker region of neuropilin-2 are necessary and sufficient for its polysialylation and serve as better recognition and acceptor sites in the polysialylation process than those regions of neuropilin-1. In addition, specific acidic residues on the surface of the MAM domain are critical for neuropilin-2 polysialylation. Based on these data and pull-down experiments, we propose a model where ST8SiaIV recognizes and docks on an acidic surface of the neuropilin-2 MAM domain to polysialylate O-glycans on the adjacent linker region. These results together with those related to neural cell adhesion molecule polysialylation establish a paradigm for the process of protein-specific polysialylation.
Magnetic resonance imaging of the brain in patients with acute monosymptomatic optic neuritis

Ophthalmologists and neurologists from a catchment area of 1.5 million people were asked to refer all patients with symptoms and signs of optic neuritis (ON) to our neurological department immediately. A total of 68 consecutive patients were extensively screened for known etiologies of ON. Eleven had definite multiple sclerosis (MS); 7 patients could not participate for various reasons. The cerebrum, cerebellum and brainstem of the remaining 50 untreated patients with monosymptomatic ON were MRI scanned at 1.5 T with 2 sequences (slice thickness 4 mm, voxel size 1.2 × 1.2 × 4 mm3): double spin‐echo (TR = 1.8 s, TE = 30 and 90 ms, 12 slices axially) and inversion recovery (TR = 2.45 s, TI = 400 ms, TE = 30 ms, 5 slices sagittally). Magnetic resonance imaging (MRI) was performed within 3–49 (median 16) days from onset of symptoms. MRI demonstrated multiple asymptomatic central nervous system (CNS) lesions in 62% of patients. The appearance, locations and extents of lesions were consistent with demyelination. A scoring system based on number and size of lesions is proposed. Seven of 50 patients developed definite MS during a median follow‐up of 11 months; they all had CNS lesions on the first scan. MRI has thus improved the pathophysiological knowledge of idiopathic ON, which from the very onset is a manifestation of MS in at least two thirds of cases. Patients who have early CNS lesions run a much higher risk of later developing clinically definite MS.
Utah youth suicide study, phase I: government agency contact before death.

OBJECTIVE To delineate the probability of contact between government agencies and youths who complete suicide, to investigate the nature of those contacts, and to identify new risk factors for suicide. METHOD A descriptive epidemiological analysis of data from multiple Utah government agencies on consecutive youth suicides (n = 151) between August 1, 1996, and June 6, 1999, aged 13-21 years. Data were collected from four government agencies: Office of the Medical Examiner, Juvenile Justice, Department of Human Services, and the Department of Education. RESULTS Utah descriptive data were similar to national statistics, with the majority of completers being male (89%) and firearms the most common method of suicide (58%). The data demonstrated an association between youth suicide and contact with Juvenile Justice. Sixty-three percent of youths who completed suicide in Utah had contact with Juvenile Justice, and there was a direct correlation between number of referrals and increased suicide risk. Suicide completers had multiple minor offenses over many years. A significant minority of school-age subjects could not be located within the school system. Few suicide completers had evidence of active psychiatric treatment. CONCLUSIONS Juvenile Justice is identified as a novel site for the screening and identification of youths at risk for suicide.
Taking agricultural technologies to scale: experiences from a vegetable technology dissemination initiative in Tanzania

ABSTRACT One of the widely suggested approaches to meet the increasing food demand of a substantially growing world population is sustainable intensification. We present a unique agricultural research and scaling programme in Tanzania, focusing on the key elements necessary for results related to: gender analysis; private sector engagement; social capital; improvement and adaptation; and programme performance monitoring and evaluation. Since 2014, more than 6000 farmers have benefited from either the adaptive research or the scaling component of the programme. Preliminary impact analysis results from six pilot locations indicate that programme participants realized significantly higher yields compared to non-participants. In addition to productivity improvements, introducing resistant and drought-tolerant elite vegetable varieties improved the resilience of the existing farming systems. Finally, considering the needs of both male and female participants had a positive impact on technology adoption rates and reach.
Relationship between first dorsal sacral foramen and lumbar facet joint connecting line in South Korea populations

Abstract The first sacral nerve root block (S1 nerve root block) is a practical procedure for patients with radiating lower back pain. In general, S1 nerve root block is performed under x-ray fluoroscopy. It is necessary to adjust the position of the patient and angle of fluoroscopy to properly visualize the first dorsal sacral foramen (dorsal S1 foramen). The purpose of this study was to analyze the location of dorsal S1 foramen and lumbar facet joint in S1 nerve root block. A total of 388 patients undergoing x-ray fluoroscopy–guided S1 nerve root block in the prone position were examined. X-ray fluoroscopy was fixed at the corresponding location of facet joint of L4–5 and L5-S1. The relationship of the connecting line vertical to L5-S1 facet joint and upper margin sacrum was evaluated. The surface anatomical relationships between dorsal S1 foramen and lumbar facet joint were assessed. Based on the localization of dorsal S1 foramen, the line drawn from point to upper margin sacrum passed through the dorsal S1 foramen in all cases. The horizontal distance from the spinous process to the dorsal S1 foramen was 25.9 ± 3.0 mm for men and 26.2 ± 1.4 mm for women. The horizontal distance from the between posterior superioriliac spine to the dorsal S1 foramen was 26.2 ± 2.7 mm for men and 26.8 ± 1.7 mm for women. The vertical distance from the upper margin of sacrum to dorsal S1 foramen to the dorsal S1 foramen was 45.6 ± 6.5 mm for men and 43.8 ± 6.0 mm for women. The connecting line vertical to L5-S1 facet joint and upper margin sacrum is located on the same line from the dorsal S1 foramen. For difficult cases of locating dorsal S1 foramen, the lumbar facet joint can assist in predicting the vertical location of the dorsal S1 foramen.
The Neutral Real Interest Rate

1 The views expressed in the article are the authors’ own and are not necessarily those of Norges Bank. We would like to thank Kari Due-Andresen, Bjarne Gulbrandsen, Kjersti Haare Morka, Kjersti Lyngtun Hansen, Roger Hammersland, Kjersti Haugland, Amund Holmsen, Morten Jonassen, Nina Langbraaten, Junior Maih, Kjetil Olsen, Øistein Røisland, Marianne Sturød, Ingvild Svendsen and Tørres Trovik for discussion and suggestions. 2 A more precise definition of the neutral real interest rate is provided in Section 3. 3 Wicksell (1907) wrote the following: “If, other things remaining the same, the leading banks of the world were to lower their rate of interest; say 1 per cent below its ordinary level, and keep it so for some years, then the prices of all commodities would rise and rise and rise without any limit whatever; on the contrary, if the leading banks were to raise their rate of interest, say 1 per cent above its normal level, and keep it so for some years, then all prices would fall and fall and fall without any limit except Zero”. 4 The concepts “neutral real interest rate”, “natural real interest rate” and “normal real interest rate” are used interchangeably in the literature. The expression “neutral real interest rate” is used in this article. 5 The expected real interest rate is defined as re = i – πe, where re is the expected real interest rate, i is the nominal interest rate and πe is inflation expectations (any risk premia are disregarded). Changes in the short-term real interest rate are largely determined by changes in the short-term nominal interest rate, which in turn is determined by the central bank's official policy rate. The nominal interest rate is deflated by expected inflation over the term of the nominal interest rate. In some contexts, the nominal interest rate is deflated by actual inflation during the period. These two deflation methods give rise to the concepts “ex ante” and “ex post” real interest rate. Inflation can also be measured in several ways, for example in terms of consumer prices, or in terms of an expression for underlying inflation. These factors may be of considerable significance for an empirical estimation of the real interest rate, but are of less importance for understanding the theoretical aspects of the various real interest rate concepts.
Homocysteine as a Pathological Biomarker for Bone Disease

In the last few decades, perturbation in methyl‐group and homocysteine (Hcy) balance have emerged as independent risk factors in a number of pathological conditions including neurodegenerative disease, cardiovascular dysfunction, cancer development, autoimmune disease, and kidney disease. Recent studies report Hcy to be a newly recognized risk factor for osteoporosis. Elevated Hcy levels are known to modulate osteoclastgenesis by causing detrimental effects on bone via oxidative stress induced metalloproteinase‐mediated extracellular matrix degradation and decrease in bone blood flow. Evidence from previous studies also suggests that the decreased chondrocytes mediated bone mineralization in chick limb‐bud mesenchymal cells and during the gestational period of ossification in rat model. However, Hcy imbalance and its role in bone loss, regression in vascular invasion, and osteoporosis, are not clearly understood. More investigations are required to explore the complex interplay between Hcy imbalance and onset of bone disease progression. This article reviews the current body of knowledge on regulation of Hcy mediated oxidative stress and its role in bone remodeling, vascular blood flow and progression of bone disease. J. Cell. Physiol. 232: 2704–2709, 2017. © 2016 Wiley Periodicals, Inc.
Prevention of allergic rhinitis by aldose reductase inhibition in a murine model.

BACKGROUND Allergic rhinitis, one of the most common atopic diseases, is known to be elicited by Th2 cytokine-mediated inflammatory response. We have shown earlier that a polyol pathway enzyme aldose reductase (AR) regulates airway inflammation; however its role in allergic rhinitis is not known. We have investigated the role of AR in mediating pathological symptoms associated with allergic rhinitis in mice. METHODS The wild-type (WT) mice treated without or with AR inhibitor and AR knock out (AR(-/-)) mice were sensitized by two intraperitoneal injections of ragweed pollen extract (RWE) with adjuvant alum on days 0 and 4 followed by challenge on day 11 and/or 18 and 25. The allergic rhinitis symptoms were assessed by monitoring the nasal scratch, mast cell degranulation and release of tryptase in nasal lavage, infiltration of inflammatory cells, production of inflammatory cytokines and nasal epithelium remodeling. RESULTS Sensitization and challenge of mice with RWE produced robust and reproducible pathological symptoms of allergic rhinitis as compared to control mice. AR inhibitor, fidarestat administered mice showed markedly reduced early phase response to allergen exposure such as nasal scratches, mast cells degranulation and release of tryptase in the nasal passage as well as late phase response such as inflammatory cell infiltration and release of Th2 type cytokines and nasal epithelial remodeling. Further, prevention of these events in AR(-/-)) mice suggests the role of AR in the mediation of allergic rhinitis. CONCLUSION These results indicate an important role of AR in the mediation of RWE-induced allergic rhinitis in mice and prevention by AR inhibitor, fidarestat offers a novel therapeutic approach to ameliorate allergic rhinitis.
THE EFFECTS OF DILTIAZEM (CRD‐401) ON THE MEMBRANE AND MECHANICAL PROPERTIES OF VASCULAR SMOOTH MUSCLES OF THE RABBIT

1 The effects of diltiazem on electrical and mechanical properties of vascular smooth muscles of the rabbit were examined by various experimental procedures. 2 In the pulmonary artery, diltiazem (0.1 to 10 μg/ml) did not modify the membrane potential (‐56 mV), length constant of the tissue (1.47 mm) or rectifying properties of the membrane. Diltiazem (0.1 to 10 μg/ml) did not modify the membrane potential of the mesenteric artery (‐62.5 mV). 3 Diltiazem (1 to 10 μg/ml) suppressed mechanical responses of pulmonary and mesenteric arteries induced either by direct stimulation of the muscle (1.0 s pulse) or by neural activation (0.5 ms pulse, 30 Hz and 10 s total duration). Diltiazem suppressed the contraction induced by nerve stimulation to a greater extent than that induced by direct muscle stimulation. 4 When the depolarization‐contraction relationship of the smooth muscle of the pulmonary artery was observed by voltage clamp technique, diltiazem (1 to 10 μg/ml) raised the critical membrane potential to evoke contraction from 5 mV to 12 mV, and reduced the amplitude of contraction obtained at any given depolarization level. 5 In the pulmonary artery, diltiazem (10 μg/ml) suppressed K‐induced contraction and raised the mechanical threshold, while K‐induced depolarization was not suppressed. Diltiazem (1 to 10 μg/ml) also suppressed noradrenaline‐induced contraction, raised the mechanical threshold and suppressed noradrenaline‐induced depolarization. 6 The vasodilator actions of diltiazem on the vascular smooth muscle were compared to vasodilator actions observed with other Ca‐antagonists.
Fiscal Spillovers; The Importance of Macroeconomic and Policy Conditions in Transmission

Are fiscal spillovers today as large as they were during the global financial crisis? How do they depend on economic and policy conditions? This note informs the debate on the cross-border impact of fiscal policy on economic activity, shedding light on the magnitude and the factors affecting transmission, such as the fiscal instruments used, cyclical positions, monetary policy conditions, and exchange rate regimes. The note assesses spillovers from five major advanced economies (France, Germany, Japan, United Kingdom, United States) on 55 advanced and emerging market economies that represent 85 percent of global output, looking at government-spending and tax revenue shocks during expansion and consolidation episodes. It finds that fiscal spillovers are economically significant in the presence of slack and/or accommodative monetary policy—and considerably smaller otherwise, which suggests that spillovers are large when domestic multipliers are also large. It also finds that spillovers from government-spending shocks are larger and more persistent than those from tax shocks and that transmission may be stronger among countries with fixed exchange rates. The evidence suggests that although spillovers from fiscal policies in the current environment may not be as large as they were during the crisis, they may still be important under certain economic circumstances.
Finding a Place for Deliberation and Democracy in the Manufactroversy about Climate Change

: Although climate change rhetoric increasingly circulates in public discourse, serious debate about climate change policies have only begun to emerge. An influential component of this hesitance rests in an assumed controversy among climate scientists about the origin and projected scale of climate change impacts. Certain media practices come into question that may perpetuate this sense of doubt: journalistic ethics that demand balance in media reporting and the polarization and simplification of arguments in social media. This presentation explores these spaces where scientific arguments enter the public sphere and how ethics can be used to negotiate the conflict that emerges.
Molecular identity and prevalence of Cryptococcus spp. nasal carriage in asymptomatic feral cats in Italy.

Cryptococcosis is a life-threatening fungal disease that infects humans and animals worldwide. Inhalation of fungal particles from an environmental source can cause primary infection of the respiratory system. As animals can be considered a sentinel for human diseases, the aim of this study was to determine the prevalence and molecular identity of Cryptococcus spp. in the nasal cavity of feral cats. Cats from 162 urban and rural feral cat colonies were sampled over 3 years. Of 766 cats from which nasal swabs were obtained, Cryptococcus spp. were recovered from 95 (12.6%), including 37 C. magnus (4.8%), 16 C. albidus (2.0%), 15 C. carnescens (1.9%), 12 C. neoformans (1.6%), as well as C. oeirensis (n = 3), C. victoriae (n = 3), C. albidosimilis (n = 2), Filobasidium globisporum (n = 2), C. adeliensis (n = 1), C. flavescens (n = 1), C. dimnae (n = 1), C. saitoi (n = 1), and C. wieringae (n = 1) with prevalence <1%. Thirteen Cryptococcus species were identified by polymerase chain reaction and sequencing of internal transcribed spacer amplicons. Statistical analysis did not identify any predisposing factors that contributed to nasal colonization (eg, sex, age, season, or habitat). Results suggest that asymptomatic feral cats may carry C. neoformans and other Cryptococcus species in their sinonasal cavity. Genotyping of the specific cryptococcal isolates provides a better understanding of the epidemiology of these yeasts.
Chronic Effects of Air Pollution are Probably Overestimated

Inappropriate measures of exposure, including inadequate consideration of latency in the analysis of chronic effects of air pollution, may lead to overestimation of the impact of air pollution on health effects. A relatively simple way to check the plausibility of results on chronic effects of air pollution would be to report in parallel the smoking‐associated risks.
Clinical utility of folate pathway genetic polymorphisms in the diagnosis of autism spectrum disorders

Background The rationale of the current study was to test the clinical utility of the folate pathway genetic polymorphisms in predicting the risk for autism spectrum disorders (ASD) and to address the inconsistencies in the association of MTHFR C677T and hyperhomocysteinemia with ASD. Patients and methods An artificial neural network (ANN) model was developed from the data of 138 autistic and 138 nonautistic children using GCPII C1561T, SHMT1 C1420T, MTHFR C677T, MTR A2756G, and MTRR A66G as the predictors of autism risk. A neuro fuzzy model was developed to explore the genetic determinants of homocysteine. Meta-analyses were carried out on 1361 ASD children and 6591 nonautistic children to explore the association of MTHFR C677T and homocysteine with the risk for ASD. Results The ANN model showed 63.8% accuracy in predicting the risk of autism. Hyperhomocysteinemia was observed in autistic children (9.67±4.82 vs. 6.99±3.21 &mgr;mol/l). The neuro fuzzy model showed synergistic interactions between MTHFR C677T and MTRR A66G inflating homocysteine levels. The meta-analysis showed MTHFR to be a genetic risk factor for autism in both fixed-effects (odds ratio: 1.47, 95% confidence interval: 1.31–1.65) and random-effects (odds ratio: 1.57, 95% confidence interval: 1.16–2.11) models. The meta-analysis of nine studies showed hyperhomocysteinemia as a significant risk factor for autism in both fixed-effects (P<0.0001) and random-effects (P=0.026) models. Conclusion Genetic polymorphisms of the folate pathway were moderate predictors of autism risk. MTHFR C677T and hyperhomocysteinemia have been identified as risk factors for autism worldwide. Synergistic interactions between MTHFR C677T and MTRR A66G increase homocysteine.