Miracle-dz/UniFAR-FTUs huggingface dataset:
Mini review: Individual differences and domain-general mechanisms in object recognition

Over the past three decades, object recognition moved away from domain-general questions, favoring investigation of putative category-specific mechanisms. But growing interest in individual differences in object recognition is putting the spotlight back on domain-general mechanisms, supporting their existence rather than simply assuming them. We reflect on the relative progress in three areas of visual cognition—visual object recognition, ensemble perception, and holistic processing. The study of visual object recognition abilities, based on latent variable modeling, provides strong evidence for domain-general mechanisms with neural correlates in visual areas and contributions to many real-world visual problems. The study of ensemble perception includes evidence for interesting individual differences but the structure of abilities is unclear, with a need for multivariate investigation. The study of individual differences in holistic processing has been unable to establish the construct validity of its measures. Each of these areas is at a different stage of understanding relevant underlying abilities, each one helping to illustrate different challenges that may be unfamiliar to experimentalists.
A review of the Digital Twin technology for fault detection in buildings

This study aims to evaluate the utilization of technology known as Digital Twin for fault detection in buildings. The strategy consisted of studying existing applications, difficulties, and possibilities that come with it. The Digital Twin technology is one of the most intriguing newly discovered technologies rapidly evolving; however, some problems still need to be addressed. First, using Digital Twins to detect building faults to prevent future failures and cutting overall costs by improving building maintenance is still ambiguous. Second, how Digital Twin technology may be applied to discover inefficiencies inside the building to optimize energy usage is not well defined. To address these issues, we reviewed 326 documents related to Digital Twin, BIM, and fault detection in civil engineering. Then out of the 326 documents, we reviewed 115 documents related to Digital Twin for fault detection in detail. This study used a qualitative assessment to uncover Digital Twin technology’s full fault detection capabilities. Our research concludes that Digital Twins need more development in areas such as scanner hardware and software, detection and prediction algorithms, modeling, and twinning programs before they will be convincing enough for fault detection and prediction. In addition, more building owners, architects, and engineers need substantial financial incentives to invest in condition monitoring before many of the strategies discussed in the reviewed papers will be used in the construction industry. For future investigation, more research needs to be devoted to exploring how machine learning may be integrated with other Digital Twin components to develop new fault detection methods.
Unlocking the hidden variation from wild repository for accelerating genetic gain in legumes

The fluctuating climates, rising human population, and deteriorating arable lands necessitate sustainable crops to fulfil global food requirements. In the countryside, legumes with intriguing but enigmatic nitrogen-fixing abilities and thriving in harsh climatic conditions promise future food security. However, breaking the yield plateau and achieving higher genetic gain are the unsolved problems of legume improvement. Present study gives emphasis on 15 important legume crops, i.e., chickpea, pigeonpea, soybean, groundnut, lentil, common bean, faba bean, cowpea, lupin, pea, green gram, back gram, horse gram, moth bean, rice bean, and some forage legumes. We have given an overview of the world and India’s area, production, and productivity trends for all legume crops from 1961 to 2020. Our review article investigates the importance of gene pools and wild relatives in broadening the genetic base of legumes through pre-breeding and alien gene introgression. We have also discussed the importance of integrating genomics, phenomics, speed breeding, genetic engineering and genome editing tools in legume improvement programmes. Overall, legume breeding may undergo a paradigm shift once genomics and conventional breeding are integrated in the near future.
Facteurs prédictifs d'apnées obstructives du sommeil chez des patients diabétiques et/ou obèses. A propos de 161 observations

Introduction : Les apnees obstructives du sommeil sont devenues un probleme de sante publique, en raison tout d'abord de leur incidence (5% de la population generale et jusqu'a 50% des sujets presentant une obesite severe) mais egalement en raison du risque metabolique et cardiovasculaire qui leur est associe. Au dela du poids, la repartition corporelle de la masse grasse (MG) semble etre un determinant important pour predire l'existence et la severite d'apnees obstructives du sommeil.Methodes : Nous avons etudie la composition corporelle par mesures anthropometriques et absorptiometrie biphotonique (DEXA) chez 161 sujets (49 hommes et 112 femmes) obeses et / ou diabetiques, ayant egalement beneficie d'un depistage d'apnees du sommeil par polygraphie ventilatoire dans le service de diabetologie, maladies metaboliques et nutrition du CHU de Nancy.Resultats : L'analyse bivariee des parametres clinico-biologiques revelent que l'IAH (indice d'apnee-hypopnee) est significativement correle au tour de cou, tour de taille (uniquement chez les femmes) a l'existence d'un diabete de type 2, a l'HTA, a l'âge, au sexe masculin mais pas a l'IMC. L'analyse bivariee de la composition corporelle revele que l'IAH est significativement correle a la MG abdominale et au rapport MG abdominale / MG des membres inferieurs chez les femmes et significativement correle a la MG abdominale ainsi qu'a la MG du corps entier chez les hommes. En analyse multivariee, l'IAH est independamment correle chez les femmes a l'âge, al'existence d'un diabete de type 2, au tour de taille, a l'IMC, a la MG abdominale et aurapport MG abdominale / MG des membres inferieurs et chez les hommes a l'âge, au tour de taille, a la MG abdominale et au rapport MG totale / masse totale. En revanche, il nexiste pas de correlation entre IAH et MG cervicale ou le tour de cou, chez les hommes comme chez les femmes.Conclusion : L'obesite androide est un meilleur facteur predictif d'apnees obstructives du sommeil que la MG totale alors qu'il n'existe pas de correlation entre IAH et MGoropharyngee, MG cervicale ou tour de cou. La MG abdominale est tres certainementimpliquee dans physiopathologie des apnees obstructives du sommeil. Si le depistage doit etre systematique dans les sous-populations d'obeses severes du fait de sa forte prevalence, le depistage doit aussi etre propose aux sujets en surpoids ou presentantune obesite plus moderee, si celle-ci est abdominale. L'existence d'une correlationsignificative et independante entre IAH et diabete de type 2 incite egalement au depistage chez les sujets diabetiques
ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression

ZC3H11A is a cellular protein associated with the transcription export (TREX) complex that is induced during heat-shock. Several nuclear-replicating viruses exploit the mRNA export mechanism of ZC3H11A protein for their efficient replication. Here we show that ZC3H11A protein plays a role in regulation of NF-κB signal transduction. Depletion of ZC3H11A resulted in enhanced NF-κB mediated signaling, with upregulation of numerous innate immune related mRNAs, including IL-6 and a large group of interferon-stimulated genes. IL-6 upregulation in the absence of the ZC3H11A protein correlated with an increased NF-κB transcription factor binding to the IL-6 promoter and decreased IL-6 mRNA decay. The enhanced NF-κB signaling pathway in ZC3H11A deficient cells correlated with a defect in IκBα inhibitory mRNA and protein accumulation. Upon ZC3H11A depletion The IκBα mRNA was retained in the cell nucleus resulting in failure to maintain normal levels of the cytoplasmic IκBα mRNA and protein that is essential for its inhibitory feedback loop on NF-κB activity. These findings indicate towards a previously unknown mechanism of ZC3H11A in regulating the NF-κB pathway at the level of IkBα mRNA export. Graphical Abstract ZC3H11A depletion resulted in the retaining of IkBa mRNA in the cell nucleus, failing to maintain normal levels of the cytoplasmic IkBa mRNA and protein that is essential for its inhibitory feedback loop on NF-kB activity.
TRPV1 in dorsal root ganglion contributed to bone cancer pain

Tumor growth in situ or bone metastases in cancer patients all can induce bone cancer pain. It is frequently occurred in patients with breast, prostate, and lung cancer. Because of the lack of effective treatment, bone cancer pain causes depression, anxiety, fatigue, and sleep disturbances in cancer patients, disrupts the daily quality of life, and results in huge economic and psychological burden. Over the past years, transient receptor potential channels (TRPs), especially TRP vanilloid 1 (TRPV1) in dorsal root ganglion (DRG), have been considered to be involved in bone cancer pain. The characteristic of TRPV1 had been well studied. The mechanisms under TRPV1 regulation in DRG with bone cancer pain are complex, including inflammatory mediators, endogenous formaldehyde, and other mechanisms. In the present review, we summarize the role and potential mechanism of TRPV1 in DRG in bone cancer pain. As the primary sensory neurons, targeting the TRPV1 channel in DRG, might have fewer side effects than in central. We hope systematically understand of TRPV1 modulation in DRG will bring more effective strategy.
Higher general executive functions predicts lower body mass index by mitigating avoidance behaviors

Background The present study examines the relationship between obesity, executive functions, and body image in a nonclinical population from southern Italy. Methods General executive functioning (Frontal Assessment Battery–15), and body image disturbances (Body Uneasiness Test) were assessed in a sample including 255 participants (138 females, M age = 43.51 years, SD = 17.94, range = 18–86 years; M body mass index (BMI) = 26.21, SD = 4.32, range = 18.03–38.79). Findings Multiple Linear Regression Analysis indicated that age, years of education, FAB15 score, body image concerns, and avoidance predicted the variance of BMI. A subsequent mediation analysis highlighted that the indirect effect of FAB15 on BMI through avoidance was statistically significant. Interpretation Our results suggest that more performing executive functioning predicts a decrease in BMI that is partially due to the mitigation of avoidance behaviors.
A Pilot Randomised Controlled Trial to Enhance Well-Being and Performance of Athletes in Para Sports

Existing mindfulness and acceptance-commitment programs in elite sport have ignored elite athletes with a physical disability. A pilot randomised controlled trial was conducted to determine if an eight-session mindfulness-acceptance-commitment program delivered within a motivational interviewing framework would enhance well-being in Para-Sport athletes. Eighteen Para-Sport athletes were randomly assigned to either intervention (n = 9) or waitlist control (n = 9) groups, with the intervention group attending eight 60-minute face-to-face individual sessions. Analysis of covariance showed statistically significant improvements in the primary outcomes of satisfaction with life (subjective well-being), personal growth, positive relation with others (psychological well-being) with large effect sizes (i.e., partial eta squared range = .23 to .30). Significant improvements for secondary outcomes were observed for a reduction in perceptions of pain (physical well-being). Although not statistically significant, moderate to large effect sizes in favour of the intervention group were also seen for multiple domains of subjective and psychological well-being. No significant or practically meaningful effect sizes were seen for social well-being. This trial provides some preliminary evidence that combining mindfulness-acceptance interventions with motivational interviewing can result in meaningful well-being improvements. Future research is needed to confirm the efficacy of this approach in adequately powered sample sizes.
Enhance or inhibit? Unveiling the influence of chairman’s hometown attachment on the corporate philanthropy–Corporate financial performance relationship

Although there have been numerous studies on the relationship between corporate philanthropy and corporate financial performance (CFP), theoretical analysis focusing on the legitimacy-based mechanism and the moderating role of key executives’ psychological characteristics is scarce. Hometown attachment is a special form of place attachment in environmental psychology, which reflects people’s psychological attachment to their hometown and the state of maintaining an intimate emotional connection with it. Based on Scott’s three-pillar institutional perspective, this study traces its origins from the Chinese cultural context, and discusses the legitimacy basis of donations in the Chinese cultural context and why donations can improve CFP. On this basis, the moderating effect of the chairman’s hometown attachment on the corporate donation–performance relationship is empirically tested. Through logical deduction, hometown attachment may form legitimacy pressure to weaken the above relationship or leverage more legitimacy resources to strengthen such a relationship. Which effect dominates? The empirical results in this study of A-share listed firms from 2009 to 2018 show that the moderating role of hometown attachment is more in line with the resource theory than the former pressure theory. Further research shows that the government and consumers are important providers of these legitimacy resources. This study reveals the mechanism for legitimacy acquisition through corporate donations in the Chinese context and answers the question of what the chairman’s hometown attachment brings about to their donation performance, providing some inspiration for practice.
The Evaluation of Serum Levels of Erythrocyte Sedimentation Rate and C-reactive Protein with CA125 as Probable Predictive Factors of Malignancy in Adnexal Masses

Background: Adnexa masses include ovarian masses, fallopian tubes and surrounding connective tissues and are among the most important and common disorders of women’s science. The aim of this study was to investigate the levels of serum ESR and CRP changes along with CA- 125 in patients with adnexal tumors. Methods: This research was a crosssectional study. The statistical population consisted of all patients who referred to Imam Khomeini Hospital of Mazandaran University of Medical Sciences during 12 months from September 2016 to September 2017 with diagnosis of adnexal mass and undergoing surgery. The sample size was 100 people who were selected through convenience sampling method. The method of data collection was such that a blood sample was taken from all patients who were candidates for adnexa masses surgery and kept at room temperature for 30 min and then centrifuged for 10 min at 4000 rpm. Data were analyzed using Mann-Whitney U test, correlation coefficient and logistic regression analysis. Results: The findings showed that elevated levels of CA125, ESR and CRP were not significantly correlated with tumor type and could not be used for screening alone. However, in cases of malignant tumors, its increased levels may indicate a higher staging of the tumor. Conclusion: According to the results, evaluation of the level of tumor marker CA125 and inflammatory markers of ESR and CRP in malignant tumor can be used to determine appropriate diagnostic therapeutic measures. Key words: Adnexal masses, CA125, C-reactive protein, Erythrocyte sedimentation rate.
Short-Term Trends in Economic Burden and Catastrophic Costs of Type 2 Diabetes Mellitus in Rural Southwest China

Objectives This study is aimed at gaining insights on the changing prevalence, economic burden, and catastrophic costs of diabetes in rural southwest China. Materials and Methods Data were collected from two cross-sectional health interviews and examination surveys among individuals aged ≥ 35 years in rural Yunnan Province. A prevalence-based cost-of-illness method was used to estimate the cost of diabetes. Information about the participants' demographic characteristics and economic consequences of diabetes was obtained using a standard questionnaire. Fasting blood sugar levels were recorded for each study participant. Results During the study period, the overall prevalence of diabetes increased from 7.7% to 9.5% (P < 0.01) and the economic cost of diabetes increased 1.52-fold. The largest increases were observed in hospital costs (1.77-fold increase), while unit medication costs fell by 18.6%. Both in 2009 and in 2016, males had higher overall direct and indirect costs of diabetes than females (P < 0.05). Direct costs represented the largest component of economic cost of diabetes while hospital costs were the main drivers of direct medical expenditures, accounting for 66.2% of the total direct costs in 2009 and 75.9% in 2016. The incidence of household catastrophic health payment and household impoverishment due to diabetes was 24.0% and 17.9% in 2009 and 23.6% and 17.6% in 2016, respectively. These rates did not differ between the two survey years (P > 0.05). Conclusions The prevalence and economic burden of diabetes increased substantially from 2009 to 2016 in rural southwest China. The findings underscore an urgent need for the government to invest more financial resources in the prevention of diabetes and improvement of access to affordable medication in rural southwest China.
Dentinal defects induced by 6 different endodontic files when used for oval root canals: an in vitro comparative study

Objectives To compare the formation of dentinal defects using stainless-steel hand K-files (HFs), rotary files, reciprocating files, and Self-Adjusting File (SAF), when used for oval root canals. Materials and Methods One hundred and forty extracted human mandibular premolar with single root and oval canal were selected for this study. Oval canals were confirmed by exposing to mesio-distal and bucco-lingual radiographs. Teeth with open apices or anatomic irregularities were excluded. All selected teeth were de-coronated perpendicular to the long axis of the tooth, leaving roots segments approximately of 16 mm in length. Twenty teeth were left unprepared (control), and the remaining 120 teeth were divided into 6 groups (n = 20) and instrumented using HF (size 40/0.02), Revo-S (RS; size 40/0.06), ProTaper NEXT (PTN; size 40/0.06), WaveOne (WO; size 40/0.09), RECIPROC (RC; size 40/0.06), and the SAF (2 mm). Roots were then sectioned 3, 6, and 9 mm from the apex, and observed under stereomicroscope, for presence of dentinal defects. “No defect” was defined as root dentin that presented with no visible microcracks or fractures. “Defect” was defined by microcracks or fractures in the root dentin. Results The control, HF, and SAF did not exhibit any dentinal defects. In roots instrumented by RS, PTN, WO, and RC files exhibited microcracks (incomplete or complete) in 40%, 30%, 55%, and 50%, respectively. Conclusions The motor-driven root canal instrumentation with rotary and reciprocating files may create microcracks in radicular dentine, whereas the stainless-steel hand file instrumentation, and the SAF produce minimal or less cracks.
Unified interactive multiple objective programming

: Previous research has stressed the philosophical, strategic, and taxonomical differences among the procedures of interactive multiple objective programming. In this paper, however, we pursue a completely different tack by examining the all but overlooked implementation similarities of the interactive procedures. In doing so, the paper demonstrates how the preponderance of interactive procedures can be made to fit a single algorithmic outline. Then, by introducing the concept of the
Serum sclerostin as a potential biomarker of vascular and valvular types of calcification in chronic kidney disease cases with and without maintenance hemodialysis

ABSTRACT Introduction: Vascular calcification (VC) is one of the factors involved in the increased cardiovascular risk observed in chronic kidney disease. Sclerostin is known to be a down regulator of bone mineralization, and a potential molecule linking the bone-vascular axis. The present study aimed at measuring serum sclerostin level in both dialyzed and undialyzed cases and correlating its serum level with both vascular and valvular types of calcification. Methods: This case control study was conducted on 82 Egyptian subjects of comparable age and gender divided into 20 apparently healthy volunteers as well as 62 chronic kidney disease cases of whom 31 cases were under maintenance hemodialysis (HD) for more than 6 months. Serum sclerostin was measured using an enzyme immunoassay. Results: Significantly higher median serum sclerostin values were observed in each of dialyzed and undialyzed cases compared to each others and to control group. Serum sclersotin was positively correlated with old age, male gender, and VC in dialyzed cases, and inversely correlated with estimated glomerular filtration rate in total number of cases. Diagnostic performance of serum sclerostin revealed a sensitive rather than a specific biomarker of both vascular and valvular types of calcification. Multiple regression analysis revealed an independent contribution of male gender, estimated glomerular filtration rate, and valvular calcification to serum sclerostin level. Conclusion: Serum sclerostin level could be used as a potential biomarker for both vascular and valvular types of calcification in chronic kidney disease cases regardless maintenance HD as a treatment modality.
Unusual Suspect: A Case Report of Tubulocystic Renal Cell Carcinoma with Features of Cystic Renal Oncocytoma

Tubulocystic renal cell carcinoma is an uncommon subtype of renal cell carcinoma that was only recently acknowledged by the World Health Organization. There is a relatively small collection of literature dedicated to the features and clinical course of this lesion. Despite its rarity, this diagnosis should remain in the differential for all cystic renal masses. We present a case report of tubulocystic renal cell carcinoma (TC-RCC) with remarkable similarity to cystic renal oncocytoma, highlighting the diagnostic challenges associated with this unusual renal malignancy.