Miracle-dz/UniFAR-FTUs huggingface dataset:
EFFECT OF MULTI-ENZYMES ORAL ADMINISTRATION ON OXIDATIVE STRESS, ANTIOXIDANT ENZYMES, AND BLOOD INDICES OF GROWING RABBIT MALES

The present research aimed to study the impacts of diverse doses of multienzymes (ME) ZAD oral administration on oxidative stress, some antioxidant enzymes, and blood indices of growing rabbit males. At 4 weeks (average body weight 527.64±15.78 g), forty-five weaned rabbit males from V-line (VL) were randomly distributed to three groups. The control group received orally 1.0 ml distilled water (0.0 ZAD), the experimental groups administrated orally with 0.75, and 1.25 ml ZAD/rabbit/day, respectively. The experimental period lasted for 6 weeks. The values of derived compounds of reactive oxygen metabolites were decreased significantly (P≤0.01) with ME oral administration (ZAD) levels, however, the values of total antioxidant capacity, superoxide dismutase, and glutathione S-transferase were enhanced significantly (P≤0.05). The results indicated that improvement of the scavenging capacity of the antioxidant defense system against oxidative stress processes in the treatment groups. The parameter hematological values containing red blood cell counts, hemoglobin, packed cell volume and mean corpuscular volume were improved significant (P≤0.05) with V-line rabbits groups which treated with ME oral administration (ZAD) comparing with the control group. Some values of hematological blood in treated groups as mean corpuscular hemoglobin, and Mean corpuscular hemoglobin concentration and platelets count did not differ from those of the control group. There were highly significant differences (P≤0.001) between treatments on white blood cell counts, lymphocytes%, and neutrophils (N): lymphocytes (L) also were significant differences (P≤0.01) between treatments on neutrophils%. The highest value of WBC count and L% (12.11x103/μL and 63%), respectively noted with rabbits received 1.25 ZAD/rabbit/day, while recording the lowest value of N% and N: L (25.9% and 0.41), respectively.
Treatment delays during FOLFOX chemotherapy in patients with colorectal cancer: a multicenter retrospective analysis.

Background FOLFOX (folinic acid, 5-fluorouracil and oxaliplatin) is the most commonly used chemotherapy regimen for the treatment of colorectal cancer. FOLFOX is administered in 14-day cycles, though toxicities frequently lead to unplanned delays. We report the incidence of unplanned delays among patients receiving FOLFOX and describe the reasons for delays. Methods We conducted a retrospective analysis of patients receiving FOLFOX chemotherapy for colorectal cancer. Patients were treated at one of two tertiary cancer centers between January 2012 and April 2016. Cycles 2-6 were assessed for delays, and treatments were considered delayed when the interval from prior treatment was >18 days. Reasons for unplanned delays were categorized based on review of clinical records. Results We identified 214 patients receiving FOLFOX as standard-of-care therapy. The median age was 59 years, and 55% were female. Of 961 evaluable treatment cycles, 124 (13%) had unplanned delays, and 92 of 214 patients (43%) had one or more unplanned delays in cycles 2-6. Cytopenias (neutropenia and/or thrombocytopenia) were the most common cause of unplanned delays, affecting 34% of patients and accounting for 74 of 124 unplanned delays (60%). Conclusions Delays are common during FOLFOX chemotherapy, with 43% of patients having at least one unplanned delay prior to completing cycle 6. Neutropenia and thrombocytopenia were the leading causes of unplanned delays. Our findings justify the development of systematic approaches for preventing unplanned delays, such as standardized laboratory treatment criteria and/or proactive dose adjustment strategies.
Psychoneuroimmunology of Stress and Mental Health

Psychoneuroimmunology (PNI) is the study of how psychological, neural, and immunologic processes interact and affect human health and behavior. Although once a relatively small field, some of the most exciting discoveries in psychopathology and mental health research have recently involved ideas and methods from PNI. In reviewing this work, I first summarize the structure and function of the human immune system, focusing primarily on inflammation. Second, I describe neural and physiologic pathways that link the brain and immune system, which give neurocognitive processes the ability to regulate the immune system and immunologic processes the ability to affect neural, cognitive-emotional, and behavioral outcomes. Third, I review studies examining associations between life stress and inflammation, and inflammation and mental health. Finally, I highlight several promising avenues for future research. Overall, despite the notable impact that PNI has already had on our understanding of mental and physical health, many important questions remain unanswered.
Catecholamine-induced reverse takotsubo cardiomyopathy

Abstract Takotsubo cardiomyopathy is a syndrome characterized by transient left ventricular systolic and diastolic dysfunction, similar to an acute myocardial infarction but in the absence of significant obstructive epicardial coronary artery disease. This disease manifests predominantly in postmenopausal women in the presence of stressful triggers. We present a case of reverse takotsubo cardiomyopathy involving apical sparing, resulting from an iatrogenic overdose of epinephrine in a young man who was treated for anaphylaxis and angioedema.
Vulvovaginitis in Women: Risk Factors and Antifungal Effect of ‎Two Selected Plant Extracts on Candida species ‎

(P<0.05) was used to determine the factors associated with vulvovaginitis. Results: There was a significant association (P<0.05) with the use of birth control pills, tight underwear, tight clothing, pregnancy and vulvovaginitis. (χ2= 82.78, P<0.001, χ2= 23.06 P<0.001, χ2= 8.292 P<0.004, χ2 = 30.95 P≤0.0001 respectively). Twenty-one (21) isolates of Candida species were identified as Candida tropicalis 13(59.1%)), Candida glabrata 3(13.6%), Candida albicans 3(13.6%), Candida parasiplosis 1(4.6%) and Candida lambica 1(4.6%). Conclusion: The study demonstrates that birth control pills, tight underwear, tight clothing and pregnancy had a significant association with vulvovaginitis. All Candida species isolates were resistant to plant extracts. Women should be educated on the risk factors associated with vulvovaginitis.
REPRODUCTIVE TOXICITY AND ENDOCRINE DISRUPTION OF ORAL AND DERMAL EXPOSURE TO PESTICIDE MIXTURE IN MALE RATS

The current study was performed to assess the risk and hazards of oral & dermal exposure to chlorpyrifos & cypermethrin mixture based on some reproductive & endocrine impaired parameters as well as histopathological alterations & histomorphometric study. Eighty-five Wister male rats (weighing 130-150g) were randomly classified into four groups (a, b, c and d). Each of group (a) and (b) were further subdivided into 5 subgroups used for determination of the oral and dermal LD50. While group (c) and (d) were classified into 3 subgroups which were used for oral and dermal treatments respectively. The first subgroups of (c) and (d) were considered as control. Rats of two subgroups (c) treated orally by 2 doses 4.26 mg/kg (1/20 LD50) and 2.84 mg/kg(1/30 LD50). Rats of two subgroups (d) treated by dermal application of 2 doses70.85mg/kg (1/30 LD50) and 42.51 mg/kg (1/50 LD50). The experiment was conducted for 65 consecutive days. The results revealed that, the tested pesticides mixture caused a significant reduction in reproductive organs weights, sperm count, sperm motility percent, alive sperm percent, pseudocholinesterase and serum testosterone levels in all treated groups especially the dermally treated groups (P≤0.05), moreover there was azoospermia in most of the group of rats treated with high dermal dose. The treated groups showed a significant increase in sperm abnormalities and composite score which represent sperm DNA fragmentation. Moderate to severe histopatholoical alterations were detected in testis and epididymis of treated rats in a dose and route dependant manner in the form of germ cell desquamation, multinucleated giant cells formation and leydig cell vacuolization with disturbance in spermatogenesis. Moreover the histomorphometric parameters analysis detected significant (P≤0.05) reduction of diameter, thickness, endothelium height & lumen of seminiferous tubules and also significant reduction of sertoli cell population. There was significant increase of blood vessel wall thickness. These results indicated that the tested formulation had synergistic effects and induced significant harmful effects on male reproductive system which were more pronounced with dermal exposure.
Current perspectives in Bietti crystalline dystrophy

Abstract Bietti crystalline dystrophy (BCD) is a rare-inherited disease caused by mutations in the CYP4V2 gene and characterized by the presence of multiple shimmering yellow-white deposits in the posterior pole of the retina in association with atrophy of the retinal pigment epithelium (RPE) and chorioretinal atrophy. The additional presence of glittering dots located at the corneal limbus is also a frequent finding. The CYP4V2 protein belongs to the cytochrome P450 subfamily 4 and is mainly expressed in the retina and the RPE and less expressed in the cornea. The disease has its metabolic origin in the diminished transformation of fatty acid substrates into n-3 polyunsaturated fatty acids due to a dysregulation of the lipid metabolism. In this review, we provide updated insights on clinical and molecular characteristics of BCD including underlying mechanisms of BCD, genetic diagnosis, progress in the identification of causative genetic and epigenetic factors, available techniques of exploration and development of novel therapies. This information will help clinicians to improve accuracy of BCD diagnosis, providing the patient reliable information regarding prognosis and clinical prediction of the disease course.
Design of Wideband Power Amplifier in 130nm CMOS for LTE Applications

— Multiband power amplifier (PA) has become a crucial requirement for mobile communication systems that operate in variety bandwidth ranges along with different frequencies and output power. Replacement of more than two power amplifiers (PAs) by a single wideband PA is required to minimize power consumption and the chip size. This paper proposes, a wideband PA withfiltered matching network (FMN) to provide a wider bandwidth while improving linearity by harmonic suppression. The proposed matching network offers an operating bandwidth of 1.47GHz from the frequency 900MHz towards 2370MHz, covering 24 LTE frequency bands. The frequency range is achieved at maximum output power of 27.5dBm with linear power of 26dBm at 1-dB point. The ACLR value of -34dBc is achieved at 1-dB output power which is within the requirement of LTE linearity specification.
Promoting Physical Activity in a Primary Care Practice: Overcoming the Barriers

Along with proper diet and avoidance of tobacco use, physical activity is extremely important to maintain and improve overall health of the individual and population. Despite evidence for the cost-effectiveness of physical activity counseling in primary care, only one-third of patients report that they received physical activity counseling by their primary care physician (PCP). Both PCPs and patients face numerous barriers to addressing insufficient physical activity. To assist patients in overcoming their barriers to regular physical activity, the PCP should assess and address the patient’s specific barriers to physical activity and counsel patients about the most common general barriers, such as lack of time, knowledge, and motivation. Numerous benefits and barriers are present, and the PCP should understand them and use the information to better counsel patients regarding the benefit of and need for regular physical activity. Brief counseling is an efficient, effective, and cost-effective means to increase physical activity and to bring considerable clinical benefits to various patient populations.
Reverse Signaling of Tumor Necrosis Factor Superfamily Proteins in Macrophages and Microglia: Superfamily Portrait in the Neuroimmune Interface

The tumor necrosis factor (TNF) superfamily (TNFSF) is a protein superfamily of type II transmembrane proteins commonly containing the TNF homology domain. The superfamily contains more than 20 protein members, which can be released from the cell membrane by proteolytic cleavage. Members of the TNFSF function as cytokines and regulate diverse biological processes, including immune responses, proliferation, differentiation, apoptosis, and embryogenesis, by binding to TNFSF receptors. Many TNFSF proteins are also known to be responsible for the regulation of innate immunity and inflammation. Both receptor-mediated forward signaling and ligand-mediated reverse signaling play important roles in these processes. In this review, we discuss the functional expression and roles of various reverse signaling molecules and pathways of TNFSF members in macrophages and microglia in the central nervous system (CNS). A thorough understanding of the roles of TNFSF ligands and receptors in the activation of macrophages and microglia may improve the treatment of inflammatory diseases in the brain and periphery. In particular, TNFSF reverse signaling in microglia can be exploited to gain further insights into the functions of the neuroimmune interface in physiological and pathological processes in the CNS.
Pursuit Evasion with Multiple Pursuers : Capturing a Ground Vehicle on a Road Network with Multiple Drones

Unmanned Aerial Vehicles (UAV) have many military and civilian applications, one of which is monitoring a given area (such as a road network) for threats. An important question in this application is to determine the latest time to dispatch UAVs for the guaranteed capture of threats attempting to travel through the network. In this work, we consider a pursuit evasion scenario with multiple pursuers (UAVs) trying to catch a single evader (ground vehicle), where information about the evader’s path is provided by ground sensors. In this scenario, we consider the problem of finding the maximum delay with which the pursuers can enter the network and still guarantee capture of the evader; we call this the Maximum Pursuer Delay Problem, or MPDP. We consider policies that split the graph into multiple instances of the single pursuer MPDP. We provide a recursive algorithm to calculate such policies by splitting the graph into multiple forests and assigning a pursuer to each forest. We also propose a dynamic programming solution that considers a class of “sweeping” policies by K pursuers and has polynomial time-complexity in the number of pursuers.
Medicinal vegetal use by traditional healers in Ekiti State of Nigeria for diabetes treatment

The aim of this work was to know the effecive plants therapy for the cure and prevention of diabetes by traditional healers. Also to understand the knowledge of traditional healers about diabetes before administering herbal medicine for cure or prevention.Twenty three plant samples were identified for diabetes treatment by the traditionalists. These plants could be common among the healers because they are found all over the places and could be of faster activity than other . The healers prepared their remedies in concoction and decoction of plant part or combination of plants parts. For commercial purpose, the remedies are prepared to smooth powder in well packeged containers with instructions for use. The traditional healers relied and beleived in their diabetic remedies and so, treat solely with natural herbal preparations.
Improving an Aromatherapy Program by Implementing an Evidence-based Clinical Guideline Using Empowered Holistic Nursing Education

A home care agency provided a program for nurse delivered essential oil aromatherapy. Little documentation of the utilization of essential oils in client care was found two years after initial implementation. The aromatherapy program lacked clear guidance on how to apply the six stages of the home care nursing process. The Project Lead wrote an Evidence-Based Clinical Guideline for the home care agency Aromatherapy Program, including all six stages of the nursing process. Empowered Holistic Nurse Education theory guided the creation of nurse education materials to teach nurses to use the clinical guideline. Components of the nurse education theory were paired with the stages of rapid cycle quality improvement, Plan, Do, Study, Act. Improvement in the rate of documentation of the program indicated the project was successful with all participating homes achieving better than zero times of documentation per week and improved nurse scores on a Preand PostTest of aromatherapy knowledge. Difficulties with implementation included lack of training time outside of regular duties and accessing online materials. A finding from the Preand Post-Implementation Surveys was an increase in nurses’ perceived authority to implement evidence-based practice change. Nurse education theory is useful for nurse leaders who want to promote changes in nursing practice. Teaching and learning circles of nurses in practice co-create quality improvements in patient care. Empowered nurses contribute practice-based evidence to evidence-based practice. Areas for further study include engaging nurses in the forty to sixty-year-old demographic and working with clients who have their own aromatherapy practices.
Barriers to eye care among participants of a mobile eye clinic

Abstract Purpose: Barriers to health care present complex challenges to improving eye health in the U.S., yet few studies have quantitatively measured the impact of these barriers. This study investigated the time elapsed since a person’s most recent eye examination (TLEE) as a measure of barriers to eye care. Methods: Participants (N = 1699) from mobile clinic vision health screenings completed demographic and subjective visual function questionnaires, and then underwent comprehensive eye exams. Associations between demographics, subjective visual function, and visual acuity were analyzed with respect to TLEE. Results: Many Hispanic (34.9%) and uninsured (28.6%) participants had no previous eye exam. Although most Caucasians had a previous eye exam, 40.2% did not have an exam in the previous four years. The majority of participants with diabetes were non-compliant with recommendations of annual eye examinations. Conclusion: These results describe barriers that are specific to subpopulations, providing useful information for efforts to improve eye care access.
Prevalence and associated factors of visually impaired cataract of the better eye among adults aged 40 years and above in Mahara Medical Officer of Health Area, Sri Lanka: a cross-sectional study

Introduction: Cataract is the main cause of visual impairment in the world, accounting for 51% of global blindness. Objectives: To determine the prevalence and associated factors of visually impaired cataract of the better eye among adults aged 40 years and above in Mahara Medical Officer of Health (MOH) Area in Sri Lanka Methods: This was a community-based descriptive cross-sectional study conducted in an MOH area during the period August-October 2009. The study population consisted of 602 adults aged 40 years and above selected using cluster sampling technique. Study instruments were interviewer-administered questionnaire and a record sheet. The presence of lens opacities following ophthalmoscope examination with visual acuity less than 6/18 in the better eye was considered as cataract. Multivariate logistic regression was applied for assessment of factors associated with cataract. Results were expressed as adjusted odds ratio (aOR) and 95% confidence interval (CI). Results: The overall prevalence of visually impaired cataract of the better eye was 14.6% (95% CI=11.78, 17.42). It was 35.1% (95% CI=28.3, 41.86) among the age group of 60 years and above and 15% (95% CI=11.28, 18.72) among females and 14.4% (95% CI=9.77, 18.43) among males. After controlling confounding factors, age 60 years and above (aOR=4.72; 95% CI=3.18, 7.01), lower level of education (aOR=2.01; 95% CI=1.39, 2.89) and duration of diabetes mellitus of more than six years (aOR=2.13; 95% CI=1.11, 4.07) were found to be the associated factors. Conclusions: The burden due to prevalence of visually impaired cataract in the better eye was considered serious as it will affect the quality of life. Being elderly, lower education and longer duration of diabetes mellitus were associated with visually impaired cataract.
Scrubbing-Aware Placement for Reliable FPGA Systems

Field Programmable Gate Arrays (FPGAs) provide complex embedded blocks to ease the development of high-performance computing systems for diverse area applications, including among others space, avionics and health. Although the rich set of features is ever expanding, there is one significant shortcoming of the SRAM-based FPGAs which concerns system designers for applications demanding high reliability: their vulnerability to Single Event Upsets (SEUs) which can cause system malfunction. In this work, we propose a placement approach to improve system reliability by reducing the execution time of configuration memory scrubbing, which can be used in conjunction with other reliability mechanisms proposed in the literature. The proposed placement approach is based on i) an automated floorplanning process to shape and locate the design region(s) and ii) a modified version of the Simulated Annealing placement algorithm aiming to reduce the scrubbing time. First, we performed a set of experiments with three QUIP benchmarks to demonstrate the efficiency of the proposed approach at different device utilization levels. Moreover, we illustrated its effectiveness for three different fault tolerance schemes, where scrubbing plays a different role in each one: i) a TMR microcontroller combined with scrubbing, ii) a soft processor protected by a low-cost mitigation scheme including scrubbing and checkpointing, iii) a JPEG encoder protected by a prioritized scrubbing scheduling scheme based on module criticality levels. The experimental results showed that the proposed approach improves system reliability in all the above schemes by reducing critical timing parameters, such as mean-time-to-detect and mean-time-to-repair. This reduction leads to a modest or high reliability improvement depending on the role of scrubbing in the adopted fault tolerance (FT) scheme.