Miracle-dz/UniFAR-FTUs huggingface dataset:
Microbacterium panaciterrae sp. nov., isolated from the rhizosphere of ginseng.

Strain DCY56(T) was isolated from a soil sample taken from a ginseng field. The strain was Gram-reaction positive, catalase-positive, oxidase-negative, aerobic and non-motile. Phylogenetic analysis, based on 16S rRNA gene sequence analysis, indicated that strain DCY56(T) belonged to the genus Microbacterium. The closest relatives were Microbacterium azadirachtae AI-S262(T), Microbacterium aerolatum V-73(T) and Microbacterium phyllosphaerae DSM 13468(T) (98.0 %, 98.0 % and 97.5 % gene sequence similarity, respectively). The G+C content of the genomic DNA of strain DCY56(T) was 68.5 mol%. The DNA-DNA relatedness values between strain DCY56(T) and the most closely related type strains were lower than 36 %. The major polar lipids were phosphatidylglycerol, diphosphatidylglycerol and an unidentified glycolipid. The predominant fatty acids contained iso-C16 : 0, anteiso-C15 : 0 and anteiso-C17 : 0. The menaquinones were MK-12 and MK-13. The diagnostic diamino acid of strain DCY56(T) was ornithine. The dominant whole-cell sugars were glucose, rhamnose and ribose. The results of the genotypic analysis, in combination with chemotaxonomic and physiological data, demonstrate that strain DCY56(T) represents a novel species within the genus Microbacterium, for which the name Microbacterium panaciterrae sp. nov. is proposed. The type strain is DCY56(T) ( = KCTC 19884(T) = JCM 17839(T)).
Research on Safe Stock Model and Its Instance under Agglomerating the Space Requirement

This paper uses the quantitative analysis method to improve the safe stock model.It discusses how the cost of safe stock changes with the correlation coefficient of space requirement.It suggests the retailers to build big central warehouse,if the requirement of spaces is not under positive correlation.Safe stock management will no more be a business running separately,it uses the agglomerate effect to bring more profit for retailers.
Biomechanical, metabolic and cardiopulmonary responses of masters recreational runners during running at different speeds

ABSTRACT This study tested interactions between age and running speed on biomechanics, metabolic responses and cardiopulmonary responses. Three-hundred participants ran at preferred and standardized speeds. Age group (younger, masters [≥40 years]) by speed (self-selected 8.8 km/h, 11.2 km/h and 13.6 km/h) interactions were tested on main outcomes of sagittal kinematic, temporal spatial, metabolic and cardiopulmonary parameters. At all speeds, angular displacements of the ankle, pelvis and knee were less in masters than younger runners (Hedges g effect size range = 0.30–1.04; all p < 0.05). A significant age group by speed interaction existed for hip angular displacement (Wald χ2 = 10.753; p = 0.013). Masters runners ran at higher relative heart rates (p < 0.05) but at similar rates of oxygen use and energy expenditure. Masters runners used hip-dominant motion and step lengthening as running speed increased, but did not change centre of mass vertical displacement. This may increase mechanical stresses on tissues of the lower extremity in masters runners, especially hamstrings, hip joint and Achilles.
The k‐degree Cayley graph and its topological properties

This article introduces a new family of Cayley graphs, called k‐degree Cayley graphs, for building interconnection networks. The k‐degree Cayley graph possesses many valuable topological properties, such as regularity with degree k, logarithmic diameter, and maximal fault tolerance. We present an optimal shortest path routing algorithm for the k‐degree Cayley graph. Cycle‐embedding and clique‐embedding are also discussed. © 2005 Wiley Periodicals, Inc. NETWORKS, Vol. 47(1), 26–36 2006
SGTA antagonizes BAG6-mediated protein triage

The BAG6 complex was first identified as an upstream loading factor for tail-anchored membrane proteins entering the TRC40-dependent pathway for posttranslational delivery to the endoplasmic reticulum. Subsequently, BAG6 was shown to enhance the proteasomal degradation of mislocalized proteins by selectively promoting their ubiquitination. We now show that the BAG6-dependent ubiquitination of mislocalized proteins is completely reversible and identify a pivotal role for the small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) in specifically antagonizing this process. SGTA does not simply mask the exposed hydrophobic transmembrane domain of a mislocalized protein, thereby preventing BAG6 recruitment. Rather, SGTA actively promotes the deubiquitination of mislocalized proteins that are already covalently modified, thus reversing the actions of BAG6 and inhibiting its capacity to promote substrate-specific degradation. This SGTA-mediated effect is independent of its tetratricopeptide motifs, suggesting it does not require the actions of Hsp70 and Hsp90 chaperones. These data reveal that, in a cellular context, mislocalized protein ubiquitination is the result of a dynamic equilibrium reflecting competition between pathways that promote either protein maturation or degradation. The targeted perturbation of this equilibrium, achieved by increasing steady-state SGTA levels, results in a specific stabilization of a model mislocalized protein derived from the amyloid precursor protein, an effect that is completely negated by ensuring efficient precursor delivery to the endoplasmic reticulum. We speculate that a BAG6/SGTA cycle operates during protein maturation and quality control in the cytosol and that together these components dictate the fate of a specific subset of newly synthesized proteins.
Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands*

Xenobiotics induce the transcription of cytochromes P450 (CYPs) 2B and 3A through the constitutive androstane receptor (CAR; NR1I3) and pregnane X receptor (PXR; NR1I2), respectively. In this report, we have systematically compared a series of xenobiotics and natural steroids for their effects on mouse and human CAR and PXR. Our results demonstrate dual regulation of PXR and CAR by a subset of compounds that affect CYP expression. Moreover, there are marked pharmacological differences between the mouse (m) and human (h) orthologs of both CAR and PXR. For example, the planar hydrocarbon 1,4-bis[2-(3,5-dichloropyridyl-oxy)]benzene activates mCAR and hPXR but has little or no activity on hCAR and mPXR. In contrast, the CAR deactivator androstanol activates both mouse and human PXR. Similarly, the PXR activator clotrimazole is a potent deactivator of hCAR. Using radioligand binding and fluorescence resonance energy transfer assays, we demonstrate that several of the compounds that regulate mouse and human CAR, including natural steroids, bind directly to the receptors. Our results suggest that CAR, like PXR, is a steroid receptor that is capable of recognizing structurally diverse compounds. Moreover, our findings underscore the complexity in the physiologic response to xenobiotics.
Renal-artery stenosis.

Renal artery stenosis (RAS) can accelerate or generate progressive hypertension and renal dysfunction. The goals for treating patients with RAS are to reduce cardiovascu-lar morbidity and mortality attributable to elevated arterial pressure and to preserve renal function beyond critical stenosis. Recent, randomized trials with current anti-hypertensive agents indicate that many patients with RAS can be managed for years without renal artery revascularization. As it does elsewhere, atherosclerotic disease can progress to more severe occlusion in the renal arteries. Rapid advances in endo-vascular techniques, including stenting, make restoration of renal blood flow possible in more patients than before. Therapeutic goals are achieved by 1) avoidance of tobacco, 2) reducing arterial pressure with antihypertensive drug therapy, particularly those agents capable of blocking the renin-angiotensin system, and 3) renal revascu-larization, using balloon angioplasty and stent placement, surgical bypass, or endart-erectomy. The major clinical challenges are to identify progressive occlusive disease and to determine appropriate timing for vascular intervention.
Vehicle recognition based on saliency detection and color histogram

Vehicle recognition is one of the important parts in the intelligent transportation system. A fast vehicle recognition method is proposed to improve the performance of the vehicle recognition. Firstly, the detected image is preprocessed by the image saliency detection based on local features, which can eliminate a large number of background information to highlight the vehicle image. Then, the vehicle image which is converted color space from RGB to HSV, and the H component is counted by color histogram which is used to identify the vehicle. Finally, the positions of the vehicles are determined. The simulation results show that the method can detect the vehicles from the complex background.
Accuracies of Optimal Transmission Switching Heuristics Based on DCOPF and ACOPF

This paper considers optimal transmission switching (OTS) to reduce generation cost by removing lines from service. A mixed integer program (MIP) has been proposed to solve the OTS problem, based on the linear direct current optimal power flow (DCOPF) model. Because of excessive computation times for large, real systems, the MIP model has been followed by some heuristics, also based on the DCOPF, to obtain near-optimal solutions quickly. However, the approximations in the DCOPF model may lead to poor choices of lines to remove from service. We assess the quality of line removal recommendations that rely on a previously published, DCOPF-based heuristic, by estimating actual cost reduction with the exact ACOPF model, using the IEEE 118-bus and 300-bus test systems with several demand levels. We also extend this heuristic to be based on the ACOPF and compare the quality of its recommendations to those of the DCOPF-based heuristic. The DCOPF-based heuristic performs very poorly in several cases, even leading to cost increases sometimes. There is a need for approximations to the ACOPF which are accurate enough to produce reliably good results for OTS heuristics, but fast enough for practical use.
Sleep-waking pattern and body temperature in hypoxia at selected ambient temperatures.

We studied the effect of mild hypoxia (15% O2) and low ambient temperature (Ta = 15 degrees C) on the rat's sleep-waking pattern (SWP) and maximum-minimum core temperature (max-min Tb). Mild hypoxia at neutral Ta (29 degrees C) disrupted the SWP in the same way as low Ta during normoxia: both affected the pattern of frequency of state changes (P less than 0.01), not the pattern of epoch durations. Mild hypoxia and low Ta together caused a degree of disruption of the SWP which was the sum of each alone, i.e., additive. Although both mild hypoxia and low Ta significantly depressed max-min Tb, low Ta exerted a greater effect than mild hypoxia. Together they further depressed max-min Tb in an additive way. We conclude that mild hypoxia disrupts the rat's SWP independent of central thermoregulatory mechanisms at neutral Ta, that the effects of mild hypoxia and low Ta on the SWP are additive at the stimulus levels used, and that Ta, not inspired O2, determines Tb.
Comparative Development of Surviving Co-Twins of Vanishing Twin Conceptions, Twins and Singletons

Abstract Early loss of one fetus in a multiple gestation as a ‘vanishing’ twin is a well recognized phenomenon. It is uncertain whether this has an impact on the development of the surviving co-twin. The aim of this study is to compare the development of singletons, twins and the surviving co-twins of a vanishing twin. The 324 children born to 229 women who were recruited into the study between 1999 and 2001 formed the study population. Children were assessed at 1 year of age with Griffiths Mental and Developmental Scales. A neurological examination was performed using an optimality score to exclude those with severe neurodisability. Three hundred and five children (92 singletons, 180 twins and 33 survivors with a vanishing twin) were included. The sub- and general quotient scores in singletons and surviving co-twins of a vanishing twin did not differ significantly. Twins had significantly lower scores than singletons in all areas of development and were more likely to be born early with lower birthweights. Following adjustment for gestation and birthweight, the difference between the two groups was nullified suggesting that the slower development of twins is related to their prematurity and lower birthweight.
Pre-operative imaging for cochlear implantation: magnetic resonance imaging, computed tomography, or both?

Abstract Objective Previous studies of computed tomography (CT) and magnetic resonance imaging (MRI) before cochlear implantation have been of limited sample size, lacked statistical analysis, and been inconsistent in their conclusions. We aim to quantify the utility of CT, MRI, and their combination in order to rationalize their selection. Methods Clinical records and radiological findings were correlated retrospectively in 158 adults and children. All underwent both CT and MRI. Results A total of 27.9% (95% confidence interval (CI): 21.0–35.5) of patients had a significant radiological abnormality, but these were considered critical to subsequent management in only 12.7% (7.9–18.9). All these were detected by MRI. They were missed by CT in 6.3% (3.1–11.3). In all, 6.3% also had non-critical abnormalities that were reported only on CT. Cochlear dysmorphisms were more common in children but the overall frequency of abnormalities and their detection rates did not depend on age. Omitting CT and using MRI alone are estimated to miss no critical abnormalities (95% CI: 0–2.3 %). Conclusions While CT may be better at defining some abnormalities, MRI appears to be able to detect all abnormalities that are critical to patient management. Most candidates for cochlear implantation can therefore be assessed by MRI initially. CT is most likely to be helpful in those with a history of severe middle ear disease, meningitis, or dysmorphic syndromes, who should undergo both CT and MRI.
Determination of transcriptional units and gene products from the ftsA region of Escherichia coli

Lambda transducing phage gamma 16-2 carries the genes envA, ftsZ, ftsA, ddl, and murC and directs the synthesis of six unique proteins in ultraviolet-irradiated cells. Various derivatives of gamma 16-2 carrying smaller segments of the bacterial deoxyribonucleic acid have also been analyzed for their capacity to direct protein synthesis in ultraviolet-irradiated cells. These results, in combination with genetic results, have allowed the gene product of each of these genes to be assigned. In addition, an unidentified gene was located counterclockwise to murC between murC and murF. Analysis of the direction of transcription indicates that murC, ddl, ftsA, and ftsZ are transcribed clockwise on the Escherichia coli genetic map, and envA is transcribed counterclockwise. In addition, it is shown that each of the genes envA, ftsZ, and ftsA can be expressed independently.
A dileucine‐like sorting signal directs transport into an AP‐3‐dependent, clathrin‐independent pathway to the yeast vacuole

Transport of yeast alkaline phosphatase (ALP) to the vacuole depends on the clathrin adaptor‐like complex AP‐3, but does not depend on proteins necessary for transport through pre‐vacuolar endosomes. We have identified ALP sequences that direct sorting into the AP‐3‐dependent pathway using chimeric proteins containing residues from the ALP cytoplasmic domain fused to sequences from a Golgi‐localized membrane protein, guanosine diphosphatase (GDPase). The full‐length ALP cytoplasmic domain, or ALP amino acids 1–16 separated from the transmembrane domain by a spacer, directed GDPase chimeric proteins from the Golgi complex to the vacuole via the AP‐3 pathway. Mutation of residues Leu13 and Val14 within the ALP cytoplasmic domain prevented AP‐3‐dependent vacuolar transport of both chimeric proteins and full‐length ALP. This Leucine–Valine (LV)‐based sorting signal targeted chimeric proteins and native ALP to the vacuole in cells lacking clathrin function. These results identify an LV‐based sorting signal in the ALP cytoplasmic domain that directs transport into a clathrin‐independent, AP‐3‐dependent pathway to the vacuole. The similarity of the ALP sorting signal to mammalian dileucine sorting motifs, and the evolutionary conservation of AP‐3 subunits, suggests that dileucine‐like signals constitute a core element for AP‐3‐dependent transport to lysosomal compartments in all eukaryotic cells.
JAK/STAT Pathway in Drosophila Immunity

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway controls multiple biological processes in metazoan development and tissue homoeostasis. This creates a need for tight regulatory mechanisms to ensure proper responses. The core components of the pathway, as well as many of the regulatory molecules, are conserved in evolution and thus share similarities in organisms such as humans and fruit flies. Therefore, the fruit fly provides an amenable model system for elucidating the in vivo roles of the JAK/STAT pathway and its regulators, which are challenging to demonstrate in mammalian systems. This review will focus on describing recent advances in understanding the importance of JAK/STAT signalling in Drosophila immunity.
Vestibular Efferent System in Pigeons: Anatomical Organization and Effect upon Semicircular Canal Afferent Responsiveness

The existence of efferent neurons innervating the vestibular labyrinth in a number of species, including pigeons, has been widely reported. However, important questions remain regarding patterns of efferent innervation and the effect of efferent activation upon primary afferent responsiveness. In previous investigations, it was difficult to ascertain the specific effect of efferent activation upon ipsilateral semicircular canal afferent responsiveness produced by discrete contralateral semicircular canal stimulation. By utilizing the unique advantages offered by a newly developed mechanical stimulation method, the present study addressed this issue.
A six-year study of hydroxyapatite-coated root-form dental implants.

BACKGROUND The effect of hydroxyapatite coating of dental implants is controversial. The long-term fate of hydroxyapatite-coated implants has been the subject of some criticism. PURPOSE The aim of this retrospective study was to assess the clinical outcome of hydroxyapatite-coated cylindrical root-form endosseous Impladent dental implants (LASAK Ltd, Prague, Czech Republic) during a six-year course. METHODS Three-hundred and ninety-one consecutively placed implants were used in 169 patients and followed for four to six years. Interval and cumulative success of implants and prostheses survival was tabulated. Marginal bone loss was measured RESULTS Of the total number of implants, 98.5% achieved initial osseointegration. The cumulative success was 98.3% after one year, 97.0% after three years, 92.8% after five years and 90.4% after six years. The prostheses survival at the end of the study was 100% for fixed bridges totally supported by implants, 96.5% for fixed bridges with combined implant and tooth support, 94.2% for single crowns, 90.9% for mandibular overdentures and 81.3% for maxillary overdentures. Marginal bone loss averaged 2.4 +/- 0.8 mm at the end of five years. CONCLUSION The success rate of the investigated hydroxyapatite-coated implants was comparable with the data presented in the literature and with the results of the similar implants without hydroxyapatite-coating. However, the marginal bone loss was of interest. Longer monitoring of the implants is necessary.
BAYESIAN METHODS FOR JOINT MODELING OF LONGITUDINAL AND SURVIVAL DATA WITH APPLICATIONS TO CANCER VACCINE TRIALS

Vaccines have received a great deal of attention recently as potential therapies in cancer clinical trials. One reason for this is that they are much less toxic than chemotherapies and potentially less expensive. However, little is currently known about the biologic activity of vaccines and whether they are associated with clinical outcome. The antibody immune measures IgG and IgM have been proposed as potential useful measures in melanoma clinical trials because of their observed association with clinical outcome in pilot studies. To better understand the role of the IgG and IgM antibodies for a particular vaccine, we examine a case study in melanoma and investigate the association between clinical outcome and an individual's antibody (IgG and IgM titers) history over time. The Cox proportional hazards model is used to study the relationship between the antibody titers as a time varying covariate and survival. We develop a Bayesian joint model for multivariate longitudinal and survival data and give its biologic motivation. Various scientific features of the model are discussed and interpreted. In addition, we present a model assessment tool called the multivariate L measure that allows us to formally compare different models. A detailed analysis of a recent phase II melanoma vaccine clinical trial conducted by the Eastern Cooperative Oncology Group is presented.
Differential gene expression from the Escherichia coli atp operon mediated by segmental defferences in mRNA stability

The atp operon of Escherichia coli directs synthesis rates of protein subunits that are well matched to the requirements of assembly of the membrane‐bound H+‐ATPase (α3β3γ1δ1σ1a1b2c10–15). Segmental differences in mRNA stability are shown to contribute to the differential control of atp gene expression. The first two genes of the operon, atpl and atpB, are rapidly inactivated at the mRNA level. The remaining seven genes are more stable. It has previously been established that the translational efficiencies of the atp genes vary greatly. Thus differential expression from this operon is achieved via post‐transcriptional control exerted at two levels. Neither enhancement of translational efficiency nor insertion of repetitive extragenic palindromic (REP) sequences into the atplB intercistronic region stabilized atpl. We discuss the implications of these results in terms of the pathway of mRNA degradation and of the role of mRNA stability in the control of gene expression.
Performance study of 5G multicarrier waveforms

In the near future some of mobile communication prime objectives need to be improved, including increased capacity, higher data rate, low latency, and better quality of service. To respond to these growing demands, a modification should be done at the physical layer in terms of waveforms adopted. Flexible waveforms have been proposed to meet the challenges faced in current generation systems such as: Filter Bank Multi Carrier (FBMC), Universal Filtered Multi Carrier (UFMC) and Generalized Frequency Division Multiplexing (GFDM). This paper studies 5G waveforms, their advantages for the new generation, analyses their performance and makes a comparison between these waveforms and OFDM.
Supply chain coordination with buyback contract under different carbon emission policies

Carbon emission policies bring new challenges to the enterprise operation and supply chain management, making the decision of management more complicated. With a two-echelon supply chain consisting of one supplier and one manufacturer taken into consideration, the supply chain coordination with buyback contract under different carbon emission policies(carbon emissions tax, mandatory carbon emissions capacity, cap and trade) is researched and compared with the situation of no carbon constrain. The results show that, under different carbon policies, the buyback contract can coordinate the supply chain. The manufacture's optimal order quantity gradually decreases under unconstrained condition, cap and trade, and mandatory carbon emissions capacity, while the buyback price offered by the supplier gradually increase.