Miracle-dz/UniFAR-FTUs huggingface dataset:
Évaluation des nouveaux procédés de délignification et blanchiment en réacteur à déplacement de liqueur et comparaison avec les procédés traditionnels

Le dioxyde de chlore est le reactif le plus utilise pour le blanchiment des pâtes chimiques. En systeme batch conventionnel, environ 50% du reactif est consomme dans des reactions inutiles intervenant a l'issue des premieres etapes de delignification. L'etude des composes modeles de lignine et de la pâte kraft confirme qu'environ 5 a 6 electrons d'oxydation par unite C9 de la lignine sont suffisants pour assurer une reaction complete. Les reactions secondaires interviennent principalement apres la degradation rapide des groupements phenoliques libres. Parmi celles-ci, l'acide muconique et ses derives formes au cours des premieres etapes reagit en echangeant 2 a 4 electrons, a une vitesse similaire a celles des unites non phenoliques de la lignine, dont l'elimination est egalement favorisee par l'acide hypochloreux intermediaire. La limitation des reactions secondaires est possible en utilisant un reacteur a lit fixe de fibres, induisant un deplacement relatif de la liqueur par rapport aux fibres. L'etude hydrodynamique a permis la determination des caracteristiques des lits fixes epais a moyenne consistance (pertes de charge, dispersion axiale) en fonction des conditions operatoires. Les resultats de blanchiment ont confirme l'obtention d'une plus grande selectivite des reactions organiques en lit fixe, mais une perte d'efficacite globale en raison d'une plus grande formation de chlorate. En revanche, fonde sur un principe similaire, le procede multi-batch [DE(p)]n a charge divisee en reactif conduit a une forte augmentation de l'efficacite globale et permet d'atteindre jusqu'a 40% de diminution de la consommation en dioxyde de chlore.
Dual Substance Use of Electronic Cigarettes and Alcohol

Electronic cigarettes (ECs) are a modern nicotine delivery system that rapidly grew in widespread use, particularly in younger populations. Given the long history of the comorbidity of alcohol and nicotine use, the rising prevalence of ECs raises the question as to their role in the consumption of alcohol. Of the numerous models of ECs available, JUUL is the most popular. This narrative review aims to determine current trends in literature regarding the relationship between EC and alcohol dual use, as well as hypothesize potential pathogenic tissue damage and summarize areas for future study, including second-hand vapor exposure and calling for standardization among studies. In summary, EC users are more likely to participate in hazardous drinking and are at higher risk for alcohol use disorder (AUD). We surmise the pathogenic damage of dual use may exhibit an additive effect, particularly in pathogen clearance from the lungs, increased inflammation and decreased immune response, physical damage to epithelial cells, and exacerbation of chronic obstructive pulmonary disease (COPD)-like illnesses. A better understanding of pathogenic damages is critical to understand the risks placed on dual users when exposed to respiratory pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Cyclic Vomiting Syndrome in Children

Cyclic Vomiting Syndrome (CVS) is an underdiagnosed episodic syndrome characterized by frequent hospitalizations, multiple comorbidities, and poor quality of life. It is often misdiagnosed due to the unappreciated pattern of recurrence and lack of confirmatory testing. CVS mainly occurs in pre-school or early school-age, but infants and elderly onset have been also described. The etiopathogenesis is largely unknown, but it is likely to be multifactorial. Recent evidence suggests that aberrant brain-gut pathways, mitochondrial enzymopathies, gastrointestinal motility disorders, calcium channel abnormalities, and hyperactivity of the hypothalamic-pituitary-adrenal axis in response to a triggering environmental stimulus are involved. CVS is characterized by acute, stereotyped and recurrent episodes of intense nausea and incoercible vomiting with predictable periodicity and return to baseline health between episodes. A distinction with other differential diagnoses is a challenge for clinicians. Although extensive and invasive investigations should be avoided, baseline testing toward identifying organic causes is recommended in all children with CVS. The management of CVS requires an individually tailored therapy. Management of acute phase is mainly based on supportive and symptomatic care. Early intervention with abortive agents during the brief prodromal phase can be used to attempt to terminate the attack. During the interictal period, non-pharmacologic measures as lifestyle changes and the use of reassurance and anticipatory guidance seem to be effective as a preventive treatment. The indication for prophylactic pharmacotherapy depends on attack intensity and severity, the impairment of the QoL and if attack treatments are ineffective or cause side effects. When children remain refractory to acute or prophylactic treatment, or the episode differs from previous ones, the clinician should consider the possibility of an underlying disease and further mono- or combination therapy and psychotherapy can be guided by accompanying comorbidities and specific sub-phenotype. This review was developed by a joint task force of the Italian Society of Pediatric Gastroenterology Hepatology and Nutrition (SIGENP) and Italian Society of Pediatric Neurology (SINP) to identify relevant current issues and to propose future research directions on pediatric CVS.
Chelating Agents in Soil Remediation: A New Method for a Pragmatic Choice of the Right Chelator

Soil pollution by metal ions constitutes one of the most significant environmental problems in the world, being the ecosystems of extended areas wholly compromised. The remediation of soils is an impelling necessity, and different methodologies are used and studied for reaching this goal. Among them, the application of chelating agents is one of the most promising since it could allow the removal of metal ions while preserving the most meaningful properties of the original soils. The research in this field requires the joined contribute of different expertise spanning from biology to chemistry. In this work, we propose a parsimonious and pragmatic approach for screening among a range of potential chelating agents. This methodology, the Nurchi's method, is based on an extension of the Reilley procedure for EDTA titrations. This allows forecasting the binding ability of chelating agents toward the target polluting metal ions and those typically found in soils, based on the knowledge of the related protonation and complex formation constants. The method is thoroughly developed, and then tested by application to some representative cases. Its use and relevance in biomedical and industrial applications is also discussed.
Platelet morphology

Abstract Background The examination of a peripheral blood smear is mandatory in case of unexplained thrombocytopenia or thrombocytosis. First, the number of platelets should be estimated in order to confirm the platelet count determined by the haematology analyser, and to rule out causes of spuriously low or elevated platelet counts. Second, the size and morphological features of the platelets, which may provide information on the underlying cause of the low or enhanced platelet count, have to be assessed. Content This review summarizes the physiological and pathological features of platelet size and morphology, circulating megakaryocytes, micromegakaryocytes and megakaryoblasts, and provides an overview of current guidelines on the reporting of platelet morphology. Summary In the diagnostic work-up of a patient with thrombocytopenia, the size of the platelets is of diagnostic relevance. Thrombocytopenia with small platelets is suggestive of a defect in platelet production, whereas the presence of large platelets is more likely to be associated with enhanced platelet turnover or hereditary thrombocytopenias. Morphological platelet abnormalities may affect the granulation and the shape and are frequently associated with abnormalities of platelet size. Platelet anomalies can be found in various haematologic disorders, such as myelodysplastic syndromes, myeloproliferative neoplasms, acute megakaryoblastic leukaemia or hereditary thrombocytopenias.
Phonetic-Form constraints in Arabic coordination

Abstract This paper explores the use of bound forms in coordination constructions and ʔijjā and ʔijja in Modern Standard Arabic (MSA) and Jordanian Arabic (JA), respectively. Using the Minimalist Program (Chomsky 1995, 2000, 2005) as a theoretical framework, the paper proposes that the use of bound forms in such constructions is ruled by a Phonetic-Form constraint that prohibits cliticization of a bound form onto another bound form, i.e. the combination of two bound forms does not result in a free form; hence it is blocked. The paper demonstrates that the use of ʔijjā and ʔijja in MSA and JA, respectively, is a direct consequence of this constraint, so that ʔijjā/ʔijja is a Phonetic-Form object used to serve as a lexical host of bound forms (cf. Fassi Fehri 1993). The use of ʔijjā/ʔijja is also shown to be prosodically ruled; it is prosodically dependent so that ʔijjā/ ʔijja should be a member of the prosodic unit which also includes the preceding word.
A Rare Case of Acute Generalized Exanthematous Pustulosis with Drug-Induced Liver Injury caused by Pyrazinamide

Abstract Acute Generalized Exanthemataous Pustulosis (AGEP) is a rare acute pustular eruption that is mostly induced by drugs. Aside from cutaneous eruptions, systemic symptoms such as leukocytosis, neutrophilia, and internal organ involvement such as liver, kidney, respiratory system, and bone marrow, may occur, although uncommon. Liver involvement usually results in a two- or three-fold increase of liver enzymes and rarely exceeds that. Pyrazinamide is the first-line anti-tuberculosis drug that is potentially hepatotoxic, but rarely shows dermatologic manifestations. We report a rare case of AGEP with drug induced liver injury due to pyrazinamide in a young patient with tuberculosis.
Comparative analysis of chemical composition of some commercially important fishes with an emphasis on various Malaysian diets

Abstract This study compares the chemical composition of cockle (Anadara granosa) and some commercially important marine (Asian seabass Lates calcarifer, grouper Epinephelus bleekeri, hardtail scad Megalaspis cordyla, longtail tuna Thunnus tonggol and Indian mackerel Rastrelliger kanagurta) and freshwater (sutchi catfish Pangasius hypophthalmus, Nile tilapia Oreochromis niloticus and eel Monopterus albus) fishes in Peninsular Malaysia. The results show that the proximate composition and trace metal content were significantly different (P < 0.05) among species investigated. The mean protein content was the highest in eel (19.1%) and the lowest in sutchi catfish (13.0%) and cockle (13.0%). The mean lipid content of Indian mackerel (3.9%) was higher than cockle (2.0%), followed by eel (1.3%) and longtail tuna (0.8%). The mean ash content was the highest in Indian mackerel (1.4%) and the lowest in cockle (0.9%). Zinc and manganese contents in cockle (Zn: 61.2 mg kg−1, Mn: 22.7 mg kg−1) were very high compared to other species investigated. The copper content was minimum in sutchi catfish (1.0 mg kg−1) and a maximum in the hardtail scad (11.7 mg kg−1). Trace metal content in sutchi catfish, Nile tilapia, grouper, longtail tuna, eel and cockle followed an order Zn > Mn > Cu, whereas Asian seabass, hardtail scad and Indian mackerel followed a different order Zn > Cu > Mn. Trace metal content in the tissue of the fishes examined was within safe limits for human consumption except Mn content in the cockle and Cu content in the hardtail scad, which is a matter of concern. When considering the daily fish fat, mineral and trace metal intake, marine fishes and shellfish are better than freshwater fishes.
Evaluation of IHC Ki-67 with Clinical Correlation in Psoriasis

Abstract Introduction. Psoriasis is a chronic inflammatory skin disease with hyperproliferation, abnormal differentiation and inflammatory infiltration in epidermis and dermis. Sometimes it is clinically and histopathologically challenging to distinguish psoriasis from other non-psoriatic psoriasiform dermatoses (NPPD) like eczema, pityriasis rosea, pityriasis rubra pilaris, and lichen simplex chronicus. Ki-67 is a non-histone nuclear protein complex that regulates the cell cycle and is the most widely used proliferation immunohistochemistry (IHC) marker. Its levels have been shown to be raised in psoriasis compared to normal skin. Aim. To elucidate and compare expression of IHC Ki-67 in psoriasis and NPPD, correlate these levels with clinical variants and disease severity in psoriasis and to observe change in levels with demographic and psoriasis-related variables. Material and Methods. Thirty patients, each with clinically diagnosed psoriasis (cases), and NPPD (controls) were enrolled. Biopsy was taken for histopathology and IHC Ki-67 immunohistochemistry. Statistical analysis was performed. Results. We found a significantly higher expression of IHC Ki-67 in psoriasis as compared to all types of NPPD. The higher level of Ki-67 in pustular and erythrodermic psoriasis compared to plaque-type emphasizes the greater severity and activity of these forms. The Ki-67 expression was found to increase with increasing body surface area involvement and disease severity (PASI) in chronic plaque type. Pityriasis rubra pilaris had the highest Ki67 expression among NPPD group. Conclusion. Ki-67 is a promising tool with diagnostic and prognostic utility in psoriasis, particularly when it comes to its differentiation from nonpsoriasis psoriasiform disorders.
Mycotoxins in aquaculture: feed and food

Mycotoxins, secondary metabolites produced by molds, are responsible for causing significant economic losses due to spoilage of agricultural products but also due to direct or indirect health impact on livestock upon ingestion of mycotoxin contaminated feedstuffs. Aquaculture farmed species are not an exception and studies reporting mycotoxin-related issues in the aquaculture industry have been increasing. However, our understanding on the prevalence and impact of mycotoxins in the aquaculture sector is still lower compared to the terrestrial livestock sector. Consequently, regulatory limits and guidance values have been defined based on the studies on terrestrial farm animals. The aim of this review is to compile and critically assess mycotoxin occurrence and cooccurrence in aquaculture finished feeds, and understand the risk of mycotoxin carry-over in aquaculture seafood products. Furthermore, we aim with this review to raise awareness to the scientific community, the regulatory authorities and the aquaculture industry to the need for specific aquaculture mycotoxin maximum concentration levels for both aquaculture feeds and foods.
A A Compact Bandwidth Enhanced Antenna Loaded with SRR For WLAN/WiMAX/Satellite Applications

A compact bandwidth enhanced antenna using metamaterial single Rectangular Split Ring Resonator (RSRR) for WLAN/WiMAX/Satellite applications is presented. As the wireless modules continue to shrink, there exists a drastic demand for a compact antenna. In addition to this, the effective integration of an antenna in wireless devices acts as stand-alone implement to mitigate the effects of noise fading. The presented antenna consists of three metamaterial single RSRR and a coaxial feed. Compactness in the design is achieved with the help of coaxial feeding technique. The etching of Upper metamaterial single RSRR creates a resonance at 6 GHz (WLAN) band, with S11 < -10 dB bandwidth ranging from 5.46 – 6.7 GHz (1240 MHz). Bandwidth enhancement in the proposed design at 6 GHz, is accomplished by the two metamaterial single RSRR placed at the left and ride side of the radiating patch, just below the upper RSRR. Due to the placement of two lower RSRR the bandwidth of the proposed antenna gets enhanced from 1240 to 3120 MHz. The antenna has a size of only 20 x 18 x 2.54 mm3 . The antenna exhibits bi-directional and Omni-directional radiation characteristics in E and H-plane, respectively. Compact size, good impedance matching, stable radiation pattern and radiation efficiency greater than 95% are observed across the operational bandwidths of the designed antenna. The aforementioned advantages make the proposed antenna suitable for WLAN/WiMAX/Satellite applications.
Effects of small crystallite size on the thermal infrared (vibrational) spectra of minerals

Abstract The thermal infrared (TIR, or vibrational) emission spectra of a suite of synthetic Mg-Fe olivines exhibit notable differences from their natural igneous counterparts in terms of their band shapes, relative depths, and reduced shifts in some band positions with Mg-Fe solid solution. Comparable reflectance spectra acquired from olivine-dominated matrices and fusion crusts of some carbonaceous chondrite meteorites exhibit similar deviations. Here we show that these unusual spectral characteristics are consistent with crystallite sizes much smaller than the resolution limit of infrared light. We hypothesize that these small crystallites denote abbreviated crystal growth and also may be linked to the size of nucleation sites. Other silicates and non-silicates, such as carbonates, exhibit similar spectral behaviors. Because the spectra of mineral separates are commonly used in the modeling and analysis of comparable bulk rock, meteorite, and remote sensing data, understanding these spectral variations is important to correctly identifying the minerals and interpreting the origin and/or secondary processing histories of natural materials.
Mesenchymal Stromal Cells: Role in the BM Niche and in the Support of Hematopoietic Stem Cell Transplantation

Abstract Mesenchymal stromal cells (MSCs) are key elements in the bone marrow (BM) niche where they interact with hematopoietic stem progenitor cells (HSPCs) by offering physical support and secreting soluble factors, which control HSPC maintenance and fate. Although necessary for their maintenance, MSCs are a rare population in the BM, they are plastic adherent and can be ex vivo expanded to reach numbers adequate for clinical use. In light of HSPC supportive properties, MSCs have been employed in phase I/II clinical trials of hematopoietic stem cell transplantation (HSCT) to facilitate engraftment of hematopoietic stem cells (HSCs). Moreover, they have been utilized to expand ex vivo HSCs before clinical use. The available clinical evidence from these trials indicate that MSC administration is safe, as no acute and long-term adverse events have been registered in treated patients, and may be efficacious in promoting hematopoietic engraftment after HSCT. In this review, we critically discuss the role of MSCs as component of the BM niche, as recent advances in defining different mesenchymal populations in the BM have considerably increased our understanding of this complex environment. Moreover, we will revise published literature on the use of MSCs to support HSC engraftment and expansion, as well as consider potential new MSC application in the clinical context of ex vivo gene therapy with autologous HSC.
Effect of phenolic compounds present in Argentinian plant extracts on mycelial growth of the plant pathogen Botrytis cinerea Pers.

The polyphagous plant pathogen Botrytis cinerea has theability of growing fast under several conditions, and producing greymoulds in different plant tissues. Because of its adaptive plasticity,resistant strains have made difficult their chemical control. Therefore,new strategies of management and the use of natural compoundscould be important control alternatives. The aim of this work was tostudy the potential value of four Argentine native plant extracts andsome of its phenolic compounds as biodrugs on B. cinerea. Aqueousplant extracts of Larrea divaricata, Prosopis strombulifera, Tessariaabsinthioides and Schinus molle var. areira, were used. The capability toinhibit the mycelial growth was studied using either the crude plantextract or same its most important, detected phenolic compounds.Phenolic compounds were analyzed by Capillary Zone Electrophoresis(CZE) with UV detection, and then statistically analyzed byPrincipal Component Analysis to correlate them and their biologicalactivity against the fungus. Prosopis strombulifera and T. absinthioidesextracts did not inhibit mycelial growth while S. molle stimulated it.Larrea divaricata demonstrated inhibition above 50% at plant extractsconcentrations of 100 mg/mL.
In silico Analysis of Pasteurella multocida PlpE Protein Epitopes As Novel Subunit Vaccine Candidates

Background: Pasteurella multocida is a Gram-negative, non-motile, non-spore forming, and aerobic/anaerobic cocobacillus known as the causative agent of human and animal diseases. Humans can often be affected by cat scratch or bite, which may lead to soft tissue infections and in rare cases to bacteremia and septicemia. Commercial vaccines against this agent include inactivated, live attenuated, and non-pathogenic bacteria. Current vaccines have certain disadvantages such as reactogenicity or reversion to virulence. Therefore, the aim of this study was to reach a multi-epitope vaccine candidate that could be serotype independent and covers most incident serotypes of P. multocida. Methods: In this study, reverse vaccinology strategy was used to identify potentially immunogenic and protective epitopes. First, multiple alignments of different sequences of PlpE from various serotypes of P. multocida were analyzed to identify the conserved regions. Bioinformatics tools were then applied to predict and select epitopes for further studies. Results: Three different conserved immunogenic regions were selected according to the selected criteria, and their various sequential orders were evaluated structurally by in silico tools to find the best order. Conclusion: In searching the epitopes of PlpE to design a new vaccine candidate against pasteurellosis, we found the region 1 + region 2 + region 3 (without any linker between regions) of epitope, including the regions of PlpE protein of P. multocida, as the appropriate serotype independent vaccine candidate against pasteurellosis.
Cost effectiveness analyses of total hip arthroplasty for hip osteoarthritis: A PRISMA systematic review

Healthcare services are facing economic constraints globally with an increasingly elderly population, and greater burdens of osteoarthritis. Because of the chronic nature of osteoarthritis and the costs associated with surgery, arthroplasty is seen as potentially cost saving. There have been no systematic reviews conducted on cost effectiveness analysis (CEA) studies of total hip arthroplasty (THA) in the management of osteoarthritis. The aim of this systematic review was to evaluate CEAs conducted on THA for osteoarthritis to determine if THA is a cost‐effective intervention.