Miracle-dz/UniFAR-FTUs huggingface dataset:
CRAN, H‐CRAN, and F‐RAN for 5G systems: Key capabilities and recent advances

The world of telecommunication is witnessing a swift metamorphosis towards fifth generation cellular networks. Particularly, the rapid shift from a user centric to a device centric communication has created a tremendous impact on service complexity and network requirements. The future networks present requisite needs in ubiquitous throughput, low latency, and high reliability. They are also envisioned to provide energy efficiency, spectrum reuse, network scalability, and robustness as well as improved quality of user experience, which proves to be of ultimate importance. Accordingly, government, academic, and industrial institutions are working together to fulfill these challenging goals. Their research efforts have been extensively reported in various topics and directions, such as heterogeneous small cell networks, millimeter wave communication, massive multiple input multiple output, network function virtualization, software‐defined network, and device‐to‐device communication. More interestingly, a revolutionary network architecture based on cloud computing and centralized processing is adopted as one of the best candidates for fifth generation. It is denoted Cloud Radio Access Network (CRAN) and (H‐CRAN) in heterogeneous networks. An upgraded version, namely, Fog RAN (F‐RAN), with caching and fog computing capabilities is also presented. Environmental friendly, it ensures flexibility and scalability with reduced expenditures. This paper presents the aforementioned key technological functionalities and surveys the benefits and challenges of CRAN, H‐CRAN, and F‐RAN.
Angular distribution and azimuthal asymmetry for pentaquark production in proton-proton collisions

Angular distributions for production of the � + pentaquark are calculated for the collisions of polarized protons with polarized target protons. We compare calculations based on different assumptions concerning spin and parity (J = 1/2 ± ,3/2 ± ) of the � + state. For a wide class of interactions the spin correlation parameters describing the asymmetric angular distributions are calculated up to 250 MeV above production threshold. The deviations from the near threshold behavior are investigated.
Seed treatment , soil compaction and nitrogen management affect upland rice 1

1. Manuscript received in Nov./2015 and accepted for publication in Mar./2016 (http://dx.doi.org/10.1590/1983-40632016v4638428). 2. Empresa Brasileira de Pesquisa Agropecuária (Embrapa Arroz e Feijão), Santo Antônio de Goiás, GO, Brazil. E-mails: veneraldo.pinheiro@embrapa.br, adriano.nascente@embrapa.br, luis.stone@embrapa.br, mabio.larcerda@embrapa.br. Water availability for cultivation of irrigated rice (Oryza sativa L.) is decreasing worldwide. Therefore, new technologies are needed to grow rice under aerobic conditions, in order to produce rice grains without yield losses and with lower water consumption. This study aimed at determining the best combination of management options for producing upland rice. A randomized blocks design, in a factorial scheme, was used. The treatments consisted of a combination of five rice cultivars (BRS Caçula, BRS Serra Dourada, BRS Primavera, BRS Sertaneja and BRS Esmeralda) with two compaction pressures in the seed furrow (25 kPa or 126 kPa), two types of seed treatment (with or without pesticide) and two types of N management (all at sowing or all at topdressing). Applying N at sowing instead of at topdressing produced higher grain yield in the no-tillage system (NTS). Under this system, upland rice genotypes show higher grain yield with higher compaction pressure. Seed treatment with pesticide provided greater grain yield for the BRS Sertaneja, in NTS, and for all genotypes in the conventional tillage system (CTS). BRS Esmeralda, in NTS, and BRS Esmeralda and BRS Primavera, in CTS, were the most productive genotypes. Moreover, in NTS, the application of N at sowing and the compaction pressure on the seed furrow are important for increasing upland rice grain yield. In CTS, seed treatment is important to improve upland rice grain yield.
AMOD1: ein makroökonometrisches Modell für Österreich

In dieser Arbeit werden die theoretischen Grundlagen, Aufbau, Schatzung, Evaluation, Simulation und Optimierung von AMOD1, einem makrookonometrischen Modell der osterreichischen Volkswirtschaft, dargestellt. AMOD1 besteht aus 29 stochastischen und 28 definitorischen Gleichungen und beruht auf Jahresdaten. Schatzzeitraum ist die Periode 1977-1998. Es werden sowohl keynesianische Elemente (Nachfragesektor, teilweise adaptive Erwartungen) als auch neoklassische Elemente (Mikrofundierung, Angebotssektor, Lohn/Preis-System, teilweise rationale Erwartungen) berucksichtigt. Eine Besonderheit stellt die doppelte Disaggregierung des Konsumbereichs dar. Die Schatzung erfolgt in Subsystemen mit simultanen Systemschatzern wie SUR (scheinbar unverbundene Regression) und 3SLS (dreistufige Methode der kleinsten Quadrate, iterativ) bzw. auf Einzelgleichungsebene mit OLS (gewohnliche Methode der kleinsten Quadrate). Im Rahmen der Evaluation des Modells wird gezeigt, dass AMOD1 einem einfachen vektorautoregressiven (VAR)-Modell deutlich uberlegen ist und auch einem etablierten Modell, wie dem des IHS (Institut fur Hohere Studien), in der Prognoseleistung nicht nachsteht. In den Simulationen werden Multiplikatoren und Variationen der wirtschaftspolitischen Instrumente im historischen Kontext sowie ein importierter Preisschock und eine Erhohung der totalen Faktorproduktivitat, z.B. durch eine Erweiterung der Europaischen Union, untersucht. Die Frage nach der optimalen Stabilisierungspolitik in Bezug auf die Staatsschuld wird mit Hilfe der dynamischen Optimierung des Modells behandelt. (Autorenreferat)
Coupling behaviors of quarter-wavelength impedance transformers for wideband CPW bandpass filters

Quarter-wavelength coplanar waveguide (/spl lambda//4-CPW) impedance transformers with low and high characteristic impedance are characterized via fullwave method of moments short-open calibration (MoM-SOC) approach and further utilized as alternative K- and J-inverter networks with enhanced coupling. Network parameters are obtained and compared with those of two traditional lumped-CPW elements, demonstrating tightened coupling behaviors. The two improved /spl lambda//4 CPW bandpass filters are then constructed and their performances are optimized via cascaded topology. Predicted results show us a few attractive features, i.e., wide passband and first-order harmonic suppression as confirmed by experiment.
Expression and characterization of canine cytochrome P450 2D15.

CYP2D15 is the canine ortholog of human CYP2D6, the human CYP2D isoform involved in the metabolism of drugs such as antiarhythmics, adrenoceptor antagonists, and tricyclic antidepressants. Similar to human, canine CYP2D15 is expressed in the liver, with detectable levels in several other tissues. Three different CYP2D15 cDNA clones were obtained by RT-PCR from dog liver RNA. Two clones corresponded to variant full-length CYP2D15 cDNAs (termed CYP2D15 WT2 and CYP2D15 V1); the third was identified as a splicing variant missing exon 3 (termed CYP2D15 V2). Recombinant baculoviruses were constructed containing full-length cDNAs and used to express CYP2D15 WT2 and CYP2D15 V1 in Spodoptera frugiperda (Sf9) cells with expression levels of up to 0.14 nmol/mg cell protein. As with human CYP2D6, the recombinant CYP2D15 enzymes exhibited bufuralol 1'-hydroxylaseand dextromethorphan O-demethylase activities whencoexpressed with rabbit NADPH:P450 oxidoreductase. For bufuralol 1'-hydroxylase, apparent Km values were 4.9, 3.7, and 2.5 microM and the Vmax values were 0.14, 0.034, and 0.60 nmol/min/mg protein for dog liver microsomes, CYP2D15 WT2, and the variant CYP2D15 V1, respectively. For dextromethorphan O-demethylase, apparent Km values were 0.6, 0.6, and 2.0 microM and the Vmax values were 0.18, 0.034, and 0.057 nmol/min/mg protein for dog liver microsomes, CYP2D15 WT2, and the variant CYP2D15 V1, respectively. The human CYP2D6-specific inhibitor quinidine and the rat CYP2D1-specific inhibitor quinine were both shown to be inhibitors of bufuralol 1'-hydroxylase activity for dog liver microsomes, CYP2D15 WT2, and the CYP2D15 V1 variant with nearly equal potency. Thus, the dog expresses a CYP2D ortholog possessing enzymatic activities similar to human CYP2D6, but is affected by the inhibitors quinine and quinidine in a manner closer to that of rat CYP2D1.
Passage of Heme-Iron Across the Envelope of Staphylococcus aureus

The cell wall envelope of Gram-positive pathogens functions as a scaffold for the attachment of virulence factors and as a sieve that prevents diffusion of molecules. Here the isdgenes (iron-regulated surface determinant) of Staphylococcus aureus were found to encode factors responsible for hemoglobin binding and passage of heme-iron to the cytoplasm, where it acts as an essential nutrient. Heme-iron passage required two sortases that tether Isd proteins to unique locations within the cell wall. Thus, Isd appears to act as an import apparatus that uses cell wall–anchored proteins to relay heme-iron across the bacterial envelope.
Contact urticaria syndrome due to carboxymethylcellulose in a hydrocolloid dressing

‘‘leg’’ in Osnabrück, and the highest prevalence of ‘‘old age’’ and ‘‘leg dermatitis’’ and lowest of ‘‘hand’’ in München/Schwabing. This variation is reflected in widely different patterns of sensitization comparing patients from these centers (1). Similarly, population variation over time in one center, as observed at St. John’s, may confound ‘‘true’’ changes in contact allergy prevalence over time. We did not observe time trends since 1995 as reported from London (3). In contrast, we found only a
The RepA protein of plasmid pSC101 controls Escherichia coli cell division through the SOS response

Although plasmid copy number varies widely among different plasmid species, normally copy number is maintained within a narrow range for any given plasmid. Such copy number control has been shown to occur by regulation of the rate of plasmid DNA replication. Here we report a novel mechanism by which the pSC101 plasmid also can detect an imbalance between the cellular level of its replication protein, RepA, and plasmid‐borne RepA binding sites to inhibit bacterial DNA replication and delay host cell division when RepA is in relative excess. We show that delayed cell division occurs by RepA‐mediated induction of the SOS response and can be reversed by over‐expression of the host DNA primase, DnaG. The effects of RepA excess are prevented by introducing a surfeit of RepA binding sites. The mechanism reported here may help to limit variation in plasmid copy number and allow repopulation of cells with plasmids when copy number falls – potentially pre‐empting plasmid loss in cultures of dividing cells.
Effects of expectation and caffeine on arousal, well-being, and reaction time

The objective of this study is to determine the impact of expectation associated with placebo and caffeine ingestion. We used a three-armed, randomized, double-blind design. Two three-armed experiments varying instruction (true, false, control) investigated the role of expectations of changes in arousal (blood pressure, heart rate), subjective well-being, and reaction time (RT). In Experiment 1 (N = 45), decaffeinated coffee was administered, and expectations were produced in one group by making them believe they had ingested caffeinated coffee. In Experiment 2 (N = 45), caffeinated orange juice was given in both experimental groups, but only one was informed about the true content. In Experiment 1, a significant effect for subjective alertness was found in the placebo treatment compared to the control group. However, for RT and well-being no significant effects were found. In Experiment 2, no significant expectancy effects were found. Caffeine produced large effects for blood pressure in both treatments compared to the control group, but the effects were larger for the false information group. For subjective well-being (alertness, calmness), considerable but nonsignificant changes were found for correctly informed participants, indicating possible additivity of pharmacologic effect and expectations. The results tentatively indicate that placebo and expectancy effects primarily show through introspection.
Increased carbonylation, protein aggregation and apoptosis in the spinal cord of mice with experimental autoimmune encephalomyelitis

Previous work from our laboratory implicated protein carbonylation in the pathophysiology of both MS (multiple sclerosis) and its animal model EAE (experimental autoimmune encephalomyelitis). Subsequent in vitro studies revealed that the accumulation of protein carbonyls, triggered by glutathione deficiency or proteasome inhibition, leads to protein aggregation and neuronal cell death. These findings prompted us to investigate whether their association can be also established in vivo. In the present study, we characterized protein carbonylation, protein aggregation and apoptosis along the spinal cord during the course of MOG (myelin-oligodendrocyte glycoprotein)35–55 peptide-induced EAE in C57BL/6 mice. The results show that protein carbonyls accumulate throughout the course of the disease, albeit by different mechanisms: increased oxidative stress in acute EAE and decreased proteasomal activity in chronic EAE. We also show a temporal correlation between protein carbonylation (but not oxidative stress) and apoptosis. Furthermore, carbonyl levels are significantly higher in apoptotic cells than in live cells. A high number of juxta-nuclear and cytoplasmic protein aggregates containing the majority of the oxidized proteins are present during the course of EAE. The LC3 (microtubule-associated protein light chain 3)-II/LC3-I ratio is significantly reduced in both acute and chronic EAE indicating reduced autophagy and explaining why aggresomes accumulate in this disorder. Taken together, the results of the present study suggest a link between protein oxidation and neuronal/glial cell death in vivo, and also demonstrate impaired proteostasis in this widely used murine model of MS.
Functional Organization of the Autotransporter Adhesin Involved in Diffuse Adherence

ABSTRACT The Escherichia coli adhesin involved in diffuse adherence (AIDA-I) is a multifunctional autotransporter protein that mediates bacterial aggregation and biofilm formation, as well as adhesion and invasion of cultured epithelial cells. To elucidate the structure-function relationships of AIDA-I, we performed transposon-based linker scanning mutagenesis and constructed mutants with site-directed deletions. Twenty-nine different mutants with insertions that did not affect protein expression were obtained. Eleven mutants were deficient for one or two but not all of the functions associated with the expression of AIDA-I. Functional characterization of the transposon mutants and of an additional deletion mutant suggested that the N-terminal third of mature AIDA-I is involved in binding of this protein to cultured epithelial cells. The purified product of the putative domain could bind to cultured epithelial cells, confirming the importance of this region in adhesion. We also identified several different mutants in which invasion and adhesion were changed to different extents and two mutants in which autoaggregation and biofilm formation were also affected differently. These results suggest that although conceptually linked, adhesion and invasion, as well as autoaggregation and biofilm formation, are phenomena that may rely on distinct mechanisms when they are mediated by AIDA-I. This study sheds new light on the workings of a protein belonging to an emerging family of strikingly versatile virulence factors.
A safe microcontroller with silent CRC calculation hardware for code ROM integrity verification in IEC-60730 class-B

The microcontroller chip for motor driver, industrial appliance, and automotive chips are required to provide methods for detecting unsafe conditions by software-driven or hardware support, such as IEC-60730 qualification requirements. Small, fast, safety-conscious operations are critical for designing safe microcontrollers, because additional hardware and software overhead is required to sense a malfunction. In this paper, especially for flash instruction memory, we propose silent execution hardware calculating the CRC of the ROM data during CPU idle time without any CPU wait cost. Parallel CRC hardware and the dedicated-FSM are executed faster at the clock level compared to software CRC calculation which requires an explicit CPU wait state. The 64kB ROM integrity verification in the experimental 8051 MCU requires about 24ms of execution time at an 8Mhz clock speed without any CPU wait state when running silently in background mode, and it requires an additional 1650 gates for the proposed hardware data path.
Small Acid-Soluble Proteins with Intrinsic Disorder Are Required for UV Resistance in Myxococcus xanthus Spores

ABSTRACT Bacterial sporulation in Gram-positive bacteria results in small acid-soluble proteins called SASPs that bind to DNA and prevent the damaging effects of UV radiation. Orthologs of Bacillus subtilis genes encoding SASPs can be found in many sporulating and nonsporulating bacteria, but they are noticeably absent from spore-forming, Gram-negative Myxococcus xanthus. This is despite the fact that M. xanthus can form UV-resistant spores. Here we report evidence that M. xanthus produces its own unique group of low-molecular-weight, acid-soluble proteins that facilitate UV resistance in spores. These M. xanthus-specific SASPs vary depending upon whether spore formation is induced by starvation inside cell aggregations of fruiting bodies or is induced artificially by glycerol induction. Molecular predictions indicate that M. xanthus SASPs may have some association with the cell walls of M. xanthus spores, which may signify a different mechanism of UV protection than that seen in Gram-positive spores.
Cost-effectiveness of efavirenz vs rilpivirine in HIV patients initiating first-line combination antiretroviral therapy

Abstract Objective: In US treatment guidelines, efavirenz (EFV) is the preferred non-nucleoside reverse transcriptase inhibitor (NNRTI) for first-line HIV treatment. In the ECHO and THRIVE trials comparing EFV with another NNRTI, rilpivirine (RPV), both medications had similar virologic suppression rates at 96-weeks; however, RPV had higher rates of virologic failure and drug resistance and lower rates of discontinuation due to adverse events. This study compared the cost-effectiveness of EFV to RPV in first-line HIV treatment in the US. Methods: A Markov model with 14 health states was constructed to estimate 10-year costs and clinical outcomes from a US payer perspective for antiretroviral naïve HIV patients initiating EFV or RPV. First-line efficacy data came from 96-week results of the ECHO and THRIVE trials, which compared EFV and RPV, both in combination with two nucleos(t)ide reverse transcriptase inhibitors. Other clinical inputs, mortality rates, and costs (2011 US$) came from published sources. Subsequent therapy lines (second, third, non-suppressive) were based on US treatment guidelines and common to both treatment arms. Robustness of study results was assessed in sensitivity analyses varying model inputs by ±25%. Potential limitations of the model center on the ability of any model to capture the clinical complexity of HIV treatment. Results: In the base case, 10-year costs were lower for EFV compared to RPV ($214,031 vs $222,090). Life expectancy (8.44 years) and years without AIDS (8.40 years) were equal; years in virologic suppression were similar (EFV = 7.87 years, RPV = 7.86 years). EFV had modest cost savings compared to RPV in terms of incremental cost-effectiveness per life-year gained, life-year gained in viral suppression, and life-year gained without AIDS. In sensitivity analyses, EFV remained cost-saving compared to RPV in over 90% of scenarios, demonstrating the robustness of study results. Conclusions: EFV was predicted to be modestly cost-saving compared with RPV over 10 years in US patients initiating first-line HIV treatment. Sensitivity analyses suggest that results may hold across multiple settings.
A Flexible All-Solid-State Micro Supercapacitor and Its Application in Electrostatic Energy Management System

This paper presents a flexible, all-solid-state micro supercapacitor (MSC) employing a thin parylene-C membrane as the substrate and polyvinyl alcohol-phosphoric acid polymer gel as the solid electrolyte. The MSC is surface mounted on an electrostatic energy management system, which aims to manage the energy collected from an electrostatic energy harvester and then store it in the MSC. The system consists of three parts: an electrostatic energy harvester, a management integrated circuit, and an MSC. The MSC prototype shows a specific capacitance of 31 mF/cm2 in the solid electrolyte. The prototype without a separator has also demonstrated that the capacitance changes from 27.7 to 25.4 mF/cm2 after more than 40 bending cycles and the capacitance retention is 91.7%, which indicates that the fabricated devices have good mechanical and electrochemical stability. The system can charge a 2.5-mF MSC with the result of 0.7 V output. The flexible all-solid-state MSC has the excellent potential in wearable electronics applications. The system can be used to efficiently collect and store the energy harvested from the environment, which bridges the energy harvesters to the practical applications.
DGCR8‐mediated disruption of miRNA biogenesis induces cellular senescence in primary fibroblasts

The regulation of gene expression by microRNAs (miRNAs) is critical for normal development and physiology. Conversely, miRNA function is frequently impaired in cancer, and other pathologies, either by aberrant expression of individual miRNAs or dysregulation of miRNA synthesis. Here, we have investigated the impact of global disruption of miRNA biogenesis in primary fibroblasts of human or murine origin, through the knockdown of DGCR8, an essential mediator of the synthesis of canonical miRNAs. We find that the inactivation of DGCR8 in these cells results in a dramatic antiproliferative response, with the acquisition of a senescent phenotype. Senescence triggered by DGCR8 loss is accompanied by the upregulation of the cell‐cycle inhibitor p21CIP1. We further show that a subset of senescence‐associated miRNAs with the potential to target p21CIP1 is downregulated during DGCR8‐mediated senescence. Interestingly, the antiproliferative response to miRNA biogenesis disruption is retained in human tumor cells, irrespective of p53 status. In summary, our results show that defective synthesis of canonical microRNAs results in cell‐cycle arrest and cellular senescence in primary fibroblasts mediated by specific miRNAs, and thus identify global miRNA disruption as a novel senescence trigger.
Citocinas en el lavado broncoalveolar de pacientes con tuberculosis

RESUMEN Antecedentes: la respuesta inmunologica protectora contra Mycobacterium tuberculosis esta principalmente mediada por fagocitosmononucleares y linfocitos T, estos ultimos amplifican la capacidad de eliminacion y degradacion de los bacilos de la tuberculosis en losmacrofagos infectados. El tipo de citocinas que se produce tiene una funcion determinante para la quimioatraccion y la activacion demacrofagos y linfocitos. Objetivo: determinar el tipo de poblacion celular predominante y el patron de citocinas secretadas en el lavado broncoalveolar depacientes con diagnostico de tuberculosis. Material y metodos: la poblacion celular se identifico y cuantifico mediante tincion con Wright; las citocinas se determinaron por latecnica de ELISA y RT-PCR. Resultados: la poblacion celular predominante en el lavado broncoalveolar fue: neutrofilos 70%, monocitos 20% y linfocitos 10%. Conexcepcion de la IL-2, se demostro que las citocinas estudiadas estan elevadas significativamente en los pacientes con tuberculosis