Miracle-dz/UniFAR-FTUs huggingface dataset:
Reflecting on News Quality

This study examined the audience perspective on what constitutes quality television news programs and the effects of commercialization on news content with regards to news quality.The media is a commercial enterprise like any other business investment venture, it therefore seeks to create and supply products that are suited and demanded by its clients. Clients of all products and services demand the best quality of all they seek to purchase. The tenets of social responsibility consider quality news programs to constitute in-depth and analytical news coverage that serves the society in terms of development and ensures information dissemination for social good. The study indicated that the audience instead preferred non-comprehensive, non-analytical news stories. Based on this analysis, it was evident that quality news programs, according to audience depend on how informative it is with regards to current affairs. Among the factors that were considered important elements of news quality included informational content, depth of news coverage and insights, comprehensiveness of news stories among others.Additionally, others factors that were considered by the audience to make quality news programs included thoroughness in reporting, creativity in presentations and studio layout, clarity of thoughts and ideas during news presentations, validity in treatments of news subjects, diversity of opinions, ease of comprehensibility, considerations of gender balances and interactivity with the audiences among others factors.From the study it is evident that the audience perspective of what constitutes quality news programs differs considerably from scholarly and idealistic expectations as per the social responsibility theory.
ACCF/ACG/AHA Expert Consensus Document Expert Consensus DocumentExpert Consensus Document ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointest

WRITING COMMITTEE MEMBERS Neena S. Abraham, MD, FACG, Chair*; Mark A. Hlatky, MD, FACC, FAHA, Vice Chair†; Elliott M. Antman, MD, FACC, FAHA‡; Deepak L. Bhatt, MD, MPH, FACC, FAHA†; David J. Bjorkman MD, MSPH, FACG*; Craig B. Clark, DO, FACC, FAHA†; Curt D. Furberg, MD, PhD, FAHA‡; David A. Johnson, MD, FACG*; Charles J. Kahi, MD, MSC, FACG*; Loren Laine, MD, FACG*; Kenneth W. Mahaffey, MD, FACC†; Eamonn M. Quigley, MD, FACG *; James Scheiman, MD, FACG*; Laurence S. Sperling, MD, FACC, FAHA‡; Gordon F. Tomaselli, MD, FACC, FAHA‡
Exogenous gonadotropin supplementation to increase in vitro embryo production in Holstein donors

VIEIRA, L. M. Exogenous gonadotropin supplementation to increase in vitro embryo production in Holstein donos. [Suplementação exógena com gonadotrofinas para aumen tar a produção in vitro de embriões em doadoras Holandesas]. 2016. 77 f. T ese (Doutorado em Ciências) Faculdade de Medicina Veterinária e Zoo tecnia, Universidade de São Paulo, São Paulo, 2016. In the last years, the use of vum pick-up (OPU) and in vitro produced embryo (IVEP) technology has worldwide increased in cattle herds. The OPU-IVEP enable a rapid individual multiplication based on the female and male donor g enetic. However, Bos taurus dairy females present some peculiarities, as reduced antr al follicle population and lower oocyte quality, and these factors have been awarded as res ponsible to the reduced technique efficiency among these herds. Given the difficultie s of establishing OPU-IVEP programs with high efficiency in Bos taurus dairy cows, three studies were carried out, involvi ng different types of superstimulation treatments in lactating a d non-lactating Holstein donors. The first study aimed to increase IVEP in lactating and non-l actating Holstein dairy donors submitted to the traditional twice-daily porcine FSH (pFSH) s uperstimulation treatment prior to the OPU. For this purpose, donors (n = 15 lactating and n = 15 non-lactating Holstein cows) received the follicular wave synchronization protoc l [estradiol benzoate (EB) and progesterone (P4) based protocol] and were submitte d to superstimulation treatment in a cross-over design. Other two experiments were performed (n = 23 Holstein heifers and n = 72 non-lactating Holstein cows) to evaluate different pFSH diluents to enable superstimulation with a single injection. In general, these studies evaluated the effect of superstimulation on the plasmatic FSH profile, proportion of follicles size s previous to OPU (small: <6mm; medium: 6-10mm; and large follicles: >10mm), on i vitro embryo production and pregnancy establishment after the produced embryo transfer. T he superstimulation treatment improved the proportion of medium sized-follicles, improved oocyte competence and resulted in greater amount of blastocyst per OPU session. A single inje ction of pFSH combined with a slow release carrier (hyaluronan), resulted in similar F SH area under curve, proportion of follicles sizes previous to OPU and in vitro embryo production compared to the twice-daily superstimulating treatment. Regardless pFSH diluent and dose, superstimulating hormone resulted in greater number of blastocysts per OPU s ession compared to the non-pFSH treated donors. Additionally, similar pregnancy establishme nt was observed, regardless embryo donor treatment. Therefore, with the present data, we can conclude that regardless treatment type (pFSH diluent or dose), the superstimulation p rocedure prior to the OPU, enhanced in vitro embryo development, increased the number of blasto cy per OPU session and resulted in similar pregnancy establishment after embryo tra nsfer.
Impacts of a Self‐Help Treatment Program for Problem Gamblers

&NA; Despite availability of treatments for gamblers, few at‐risk and pathological gamblers seek help. Self‐help treatments offer a private and personalized alternative that may appeal to gamblers who need help. Objective: This study examines the impact of the self‐help treatment JEu me questionne (JMQ) on gambling behavior and severity, and reports participants’ satisfaction. Method: Forty‐seven at‐risk and pathological gamblers entered the program that involved a self‐help treatment workbook and two motivational phone interviews. Results: Among the 32 gamblers who completed the program, results indicated a significant reduction in the number of pathological gambling diagnostic criteria. This gain was maintained at the one‐ and six‐month follow‐ups. Time gambling and money spent were also significantly lower post‐treatment, but only a reduction in time spent gambling was maintained at follow‐up. Participants reported high satisfaction with the program. The discussion raises clinical and theoretical implications of these findings. &NA; Malgré la disponibilité des traitements pour les joueurs, peu de joueurs à risque et pathologiques entreprennent une démarche d'aide. Les traitements auto‐administrés (TAA) proposent une formule individualisée et peu intrusive ayant le potentiel de rejoindre les joueurs réticents afin qu'ils demandent de l'aide. Objectifs: Cette étude examine les impacts du TAA JEu me questionne (JMQ) sur les comportements de jeu et la sévérité des problèmes de jeu et documente la satisfaction des participants. Méthode: Quarante‐sept joueurs à risque et pathologiques ont débuté le programme comprenant un manuel d'autotraitement et deux rencontres téléphoniques de type motivationnel. Résultats: Parmi les 32 joueurs qui ont complété le programme, les résultats indiquent une réduction significative du nombre de critères diagnostiques du jeu pathologique. Ce gain se maintient aux suivis 1 et 6 mois. Le temps consacré au jeu et l'argent misé diminuent également lors du post‐traitement, mais seule la réduction du temps passé à jouer se maintient aux suivis. Les participants rapportent un taux élevé de satisfaction envers le programme. La discussion soulève les implications cliniques et théoriques de ces résultats.
When differences matter: rTMS/fMRI reveals how differences in dispositional empathy translate to distinct neural underpinnings of self-other distinction in empathy

Self-other distinction is crucial for empathy, since it prevents the confusion of self-experienced emotions with those of others. We aimed to extend our understanding of the neurocognitive mechanisms of self-other distinction. Thirty-one female participants underwent continuous theta burst transcranial magnetic stimulation (cTBS) targeting the right supramarginal gyrus (rSMG), a sub-region of the temporoparietal junction previously shown to be involved in self-other distinction, and the vertex, a cortical control site. Right after stimulation they completed a visuo-tactile empathy task in an MRI scanner. Self-other distinction was assessed by differences in emotion judgments, and brain activity between conditions differing in the requirement for self-other distinction. Effects of brain stimulation on self-other distinction depended on individual differences in dispositional empathic understanding: cTBS of rSMG, compared to vertex, enhanced self-other distinction in participants with lower dispositional empathic understanding, but diminished it in participants with higher empathic understanding. On the neural level, this inverse relationship between empathic disposition and self-other distinction performance was linked to a reduction of cTBS-induced rSMG activity in persons with lower dispositional empathy, and an increase in those with higher dispositional empathy. These two opposite impacts of cTBS were associated with two anatomically and functionally distinct networks. These findings open up novel perspectives on the causal role of rSMG in self-other distinction and empathy. They also suggest that considering individual differences may yield novel insights into how brain stimulation affects higher-level affect and cognition, and its neural correlates.
Fostering resilience and prosperity through a vibrant enterprise sector

poverty for some regions, such as Latin America and the Caribbean. The $10-a-day measure is an approximate threshold for measuring vulnerability to poverty across regions, which correlates with asset holdings. The measure is based on studies suggesting that, for some regions, income of at least $10 a day is necessary to achieve the degree of economic stability and resilience to shocks that characterizes middle-class households. By contrast, those living below $10 a day are vulnerable to poverty, in the sense that they face the possibility of remaining in poverty or easily entering into poverty. See, for example, López-Calva and Ortiz-Juarez 2011; Ferreira and others 2013.
Assessment of behaviour and attachment of children to public space usage in Nigeria

Every child in a city has connection with their environment and its public space. The space influences children ’ s behaviour, knowledge, attitudes and cognition. Incontrovertibly, informal learning takes place in the public space in cities of Nigeria. The study explores behaviour and attachment of children to traditional public space in Ilorin city of north-central in Nigeria. Data were collected through a survey with 500 children age 6 to 12 who were actively utilising traditional public spaces in Ilorin. The instrument that was used to measure the influence of traditional public space on children's well-being had 12 items, and was highly reliable with Cronbach ’ s alpha of 0.88. This implies that the instrument was reliable. Data were descriptively analysed using percentage, frequency, mean, standard deviation, bar charts. Results showed that children had strong attachment to their traditional public spaces, and this sense of attachment influenced their behaviour in traditional public space. Though, some of the traditional public spaces are unkempt, unhygienic and inhospitable to children utilising them. Therefore, the policy makers and profession should develop and revitalise traditional public spaces in Ilorin city so that children can fully benefit from its environment.
Search for Social Identity in Parijat’s Blue Mimosa

Parijat was born in the Tea-Estate of Darjeeling in 1937 A.D as the daughter of Kalu Sing Waiba and Amrita Moktan. Her real name was Bishnu Kumari Waiba (Waiba is a subgroup of Tamang) but she wrote under the pen name Parijat (Parijat is a night-flowering fragrant jasmine flower). She has been hailed by her contemporaries as one of the most innovative and first modern novelist of Nepal. The themes and philosophical outlook of her poems, novels and stories are influenced by her Marxist and feminist views and her own personal circumstances. Parijat suffered from a partial paralysis since her youth and ventured from her home only rarely during the past twenty years. She was unmarried and childless; a status that was not usual for a woman in Nepalese society and that is due partly to her illness and partly, it seems due to personal preference. Despite her disability, Parijat is a formidable force in Nepali literature, and her flower-filled room in a house near Balaju has become a kind of shrine for progressive Nepali writers.
Respiratory Syncytial Virus in Young Children in England - Burden and Risk Factors for Severe Disease

Respiratory syncytial virus (RSV) is a major cause of respiratory infection in infants and young children. With potential vaccines on the horizon it is essential that RSV burden is accurately calculated by age and risk group to identify optimal target populations. My PhD investigates the secondary care burden of RSV in children younger than five years in England using routinely collected national laboratory surveillance and hospital admissions data. First, I explore the use of the individual datasets to describe RSV epidemiology. Second, I use ecological time series modelling to estimate the number of weekly hospital admissions attributable to RSV. Third, I use probabilistically linked laboratory and hospital data to describe laboratory-confirmed RSV-associated hospital admissions in England for the first time, and to determine risk factors for severe RSV-associated disease. Finally, from the linked data I generate a predictive model for RSV-associated admissions in infants, and use this to estimate the national burden of RSV-associated admissions by patient and clinical characteristics. I estimate an annual average of 33,500 (95% CI: 30,400-38,500) RSV-associated admissions in children younger than five years in England. 82% (95% CI: 79-87%) of admissions for bronchiolitis in children younger than six months could be attributed to RSV. My results highlight the importance of young age (<3 months) and birth around the beginning of RSV season in the risk of RSV-associated admission, and the importance of young age, prematurity and comorbidities in the increasing severity of disease. This is the first study to use linked laboratory surveillance and hospital admissions data for RSV in England. I have produced detailed, recent estimates of RSV-associated admissions in infants and young children using multiple methods, and highlight the strengths and limitations of using routinely collected data for RSV research. My results provide essential baseline epidemiological data required for vaccine impact studies.
p38 Alpha Mitogen-Activated Protein Kinase for Ischemic Heart Disease

The p38 mitogen-activated protein kinases (p38s) are members of a key signaling pathway that responds to varied stresses, including those that contribute to heart failure. This review will focus on the ways in which p38 can be manipulated based on its mechanisms of activation and structure and how this knowledge has led to current cardiovascular clinical trials. Phosphorylation is the process through which extracellular signals are communicated to the interior of the cell and it is catalyzed by kinases. The protein kinases transfer the terminal phosphate group from ATP to the hydroxyl group of a serine, threonine, or tyrosine residue. This posttranslational modification can transform the function of the substrate protein by changing its binding partners, subcellular location, stability, and/or activity. In turn, these transformations have an impact on diverse fundamental cellular processes to alter transcription, translation, metabolism, contractility, growth, death, and/or differentiation. The 518 known protein kinases occupy a relatively high proportion (1.7%) of the human proteome of which an even higher proportion ( 30%) is modified by phosphorylation.1 The dysregulation of kinases is a common feature of many cancers, because growth signals can be inappropriately amplified by mutations that render kinases constitutively active. Consequently, drugs to inhibit kinases are the most successful and rapidly growing of the recent advances in cancer therapy. This success has occurred despite initial concerns of the constraints imposed by the high degree of homology between the ATP binding sites of different protein kinases and of the need to compete with millimolar concentrations of ATP. Initial success was achieved with imatinib (Gleevec) that targets an abnormal fusion protein kinase formed in the translocation event that creates the Philadelphia Chromosome in chronic myeloid leukemia.2 Another early success was the targeting of the human epidermal growth factor receptor 2 tyrosine kinase that is abnormally active in at least 20% of breast cancers.3 Trastuzumab (Herceptin), the antibody-based human epidermal growth factor receptor 2 tyrosine kinase ligand, prevents downstream signaling.4 The major adverse event profile in early trials of imatinib and trastuzumab have illustrated the importance of kinase signaling to cardiovascular health.5,6 Based on this observed toxicity, the key question is whether the corollary is also true, namely, that the inhibition of some kinases brings cardiovascular benefits? If this is the case, the impact of kinase inhibitors on cardiovascular disease could be similarly transformational.
Feature-aware forecasting of large-scale time series data sets

Abstract The Internet of Things (IoT) sparks a revolution in time series forecasting. Traditional techniques forecast time series individually, which becomes unfeasible when the focus changes to thousands of time series exhibiting anomalies like noise and missing values. This work presents CSAR, a technique forecasting a set of time series with only one model, and a feature-aware partitioning applying CSAR on subsets of similar time series. These techniques provide accurate forecasts a hundred times faster than traditional techniques, preparing forecasting for the arising challenges of the IoT era.
Making agricultural value chains more inclusive through technology and innovation

Some entry barriers in agricultural and agro-processing value chains, particularly for smallholder farmers and small/medium-sized processors, can be overcome with innovation and technology adoption. Technologies and innovation in these sectors have been both radical and incremental, ranging widely through biotechnology; production technologies; automation in sorting, grading, and packaging; and digital platforms and data-connected devices for market access.
INAUGURAL DISSERTATION ZUR ERLANGUNG DES DOKTORGRADES DER NATURWISSENSCHAFTLICHEN FAKULTÄT DER KARL-FRANZENS UNIVERSITÄT

Monoand bisphosphine ligands based on the 4,4’-bisquinolone structural framework (BIQUIP ligands) were generated by direct microwave-assisted palladium-catalyzed carbon– phosphorous cross-coupling reactions employing the corresponding heteroaryl bromides and diphenylphosphine as substrates. Bisquinolne-Based Monoand Diphosphine Ligands 31
Integration of Quality, Health & Safety, Environment and Social accountability under a single Management System

The aim of this paper is to integrate quality, health & safety, environmental and social accountability standards under a comprehensive management system. To attain a specific function these compliance standards have been expanded separately at different occasions. Handling with these individual management systems and confirming their in-line position with organizational business objective are always found difficult. The current situation has accelerated the demand for integrating individual management standards in conjunction with business objectives of the organizations. A holistic TQM approach can effectively consolidate the existing quality, health & safety, social accountability and environmental operations into an indivisible and cross-functional management system. To some extent, the current management standards are treated as a subgroup of TQM. The benefits of such fusion exceed the sum of fractional benefits of individually handled management systems. The synthesis does not intend combining a few management standards conjointly, rather it means projecting the several disciplines in unique management standard based on their crossfunctional inter connections. Actually, it is analytical in nature on the basis of the compliance criteria of OHSAS 18001, ISO 9001, ISO 14001 AND SA 8000. The main finding of this study concludes that, integration is feasible based on their philosophical analogies between TQM and other management standards. This paper will contribute in the way that, it establishes a model of integrated management system accompanying its implementation instructions in connection with TQM.
Heredity Indexes for Estimating Heritability Using Known and Unknown Family Data Based on the Model of Polygenic Inheritance

Objective. To establish a model for estimating genetic risk using known and unknown family data.Methods. Four simulated datasets were generated for four paternal and maternal chromosomes. 'e simulated data for children were generated from the parental data according to the Mendelian law. 'e correlation coefficient between the children’s and paternal data was calculated, and 2R was defined as the heredity index for continuous data (HIC). 'e simulated continuous data were transformed into binary data according to the gene accumulation threshold (incidence); the incidences of children in the parental no-disease group and the disease onset group were obtained; the correlation coefficient (R) was calculated as expected R (Re). 'e ratio of observed R (Ro) and Re was defined as the Heredity index for binary data (HIB). Results. Different actual pedigree data (lunula and holding a hammer in the right or left hand) were successfully used to verify the accuracy of themodel. 'e genetic risk was estimated according to the incidence in a population using a lookup table. Conclusion. Our findings indicate the reliability of the model based on the fact that the multigene effect constitutes the normal distribution. 'us, this model can be used for comprehensive analysis of the influence of genetic and nongenetic factors on the genetic phenotype and to estimate genetic risk using known and unknown family data.
The optimality-accuracy trade-off in decision under uncertainty

To reach optimality individuals ought to maximize expected payoffs. Most of the time, aiming to take the accurate decision leads to optimality. However, some cases of decision under uncertainty may imply a divergence between optimality and accuracy. In such circumstances, individuals should give away some accuracy during their decision process to reach optimality. Individuals may not consider this unusual divergence between accuracy and optimality and adopt an accuracy-maximizing behavior instead of the optimal one. Aiming to choose correctly instead of optimally induces an optimality-accuracy trade-off. As an example we can think of a doctor establishing a diagnosis based on ambiguous symptoms. He is facing two potential types of successes (correctly classifying the patient as seek or not) and thus two types of errors. Maximizing the number of successes will not be optimal as both errors do not have the same impact. We want to study how individuals solve this optimality-accuracy trade-off using a context of asymmetric payoffs in a task of perceptual discrimination. Signal Detection Theory (SDT hereafter; Green and Swets (1966), Wickens (2001)) offers a normative benchmark to understand how individuals make decisions under uncertainty. Individuals ∗thomas.jc. garcia@gmail.com †sebastien.massoni@gmail.com