Miracle-dz/UniFAR-FTUs huggingface dataset:
Neuromuscular Control and Performance during Sudden Acceleration in Subjects with and without Unilateral Acute Ankle Sprains

Neuromuscular control of posture as understood through studies of responses to mechanical sudden acceleration automatically has been previously demonstrated in individuals with chronic ankle instability (CAI), but the presence of acute condition has not been previously explored specially in a sudden acceleration. The aim of this study was to determine neuromuscular control pattern in those with and without unilateral acute ankle sprains. Design: Case control. Setting: University research laboratory. The sinker–card protocol with surface translation was be used as a sudden acceleration protocol with study of EMG upon 4 posture stabilizer muscles in two sides of the body in response to sudden acceleration in forward and backward directions. 20 young adult women in two groups (10 LAS; 23.9 ± 2.03 yrs and 10 normal; 26.4 ± 3.2 yrs). The data of EMG were assessed by using multivariate test and one-way repeated measures 2×2×4 ANOVA (P< 0.05). The results showed a significant muscle by direction interaction. Higher TA activity of left and right side in LAS group than normal group in forward direction significantly be showed. Higher MGR activity in normal group than LAS group in backward direction significantly showed. These findings suggest that compared two sides of the body in two directions for 4 muscles EMG activities between and within group for neuromuscular control of posture in avoiding fall. EMG activations of two sides of the body in lateral ankle sprain (LAS) patients were symmetric significantly. Acute ankle instability following once ankle sprains caused to coordinated temporal spatial patterns and strategy selection. Keywords—Neuromuscular response, sEMG, Lateral Ankle Sprain, posture.
MicroRNAs Contribute to Breast Cancer Invasiveness

Cancer statistics in 2018 highlight an 8.6 million incidence in female cancers, and 4.2 million cancer deaths globally. Moreover, breast cancer is the most frequent malignancy in females and twenty percent of these develop metastasis. This provides only a small chance for successful therapy, and identification of new molecular markers for the diagnosis and prognostic prediction of metastatic disease and development of innovative therapeutic molecules are therefore urgently required. Differentially expressed microRNAs (miRNAs) in cancers cause multiple changes in the expression of the tumorigenesis-promoting genes which have mostly been investigated in breast cancers. Herein, we summarize recent data on breast cancer-specific miRNA expression profiles and their participation in regulating invasive processes, in association with changes in cytoskeletal structure, cell-cell adhesion junctions, cancer cell-extracellular matrix interactions, tumor microenvironments, epithelial-to-mesenchymal transitions and cancer cell stem abilities. We then focused on the epigenetic regulation of individual miRNAs and their modified interactions with other regulatory genes, and reviewed the function of miRNA isoforms and exosome-mediated miRNA transfer in cancer invasiveness. Although research into miRNA’s function in cancer is still ongoing, results herein contribute to improved metastatic cancer management.
Teaching strategies and activities used for students' clinical placement in residential aged care facilities: a scoping review protocol.

OBJECTIVE The objective of this scoping review is to examine and map current knowledge of teaching strategies and activities used with nursing students during clinical placements in residential aged care facilities. INTRODUCTION Residential aged care facilities provide opportunities for nursing students to develop skills and interest in caring for older adults. Studies that address students' clinical placements in these settings highlight benefits of and concerns with their experiences. Insight into the state of knowledge regarding teaching strategies used in residential aged care facilities could benefit nursing education programs and help to ensure student learning is maximized. INCLUSION CRITERIA This scoping review will consider research and narrative reports on teaching activities and strategies used by nursing faculty and residential aged care facility staff in teaching nursing students. The concepts of interest include planned and intentional activities and strategies used to facilitate student learning and student clinical experiences. A clinical experience is define a student enters a residential aged care facility and is assigned an individual or individuals to care for. METHODS This scoping review will aim to locate published and unpublished literature employing a three- step search strategy. Only papers published in English from 1992 onward will be included. Data extracted from included papers will include details on the participants, context, strategy, activity and outcomes. Extracted data will be reported in a tabular form and presented narratively to address the review objective.
Progress-Based Strategy For User Engagement In mHealth Participatory Sensing

For a long time, outcome-based strategy is used as a basis of health standard in wellness program. However, in the case of mHealth participatory sensing the strategy is not always pertinent because the user of the platform is not limited to patient only, but also by a person who used the system for wellness maintenance, and by the stakeholders that collect and analyze information. To improve community’s engagement on health wellness and maintenance, we propose myCommHealth that emphasizes on progress-based strategy. myCommHealth is an open data collection platform using mobile devices and allow community and stakeholder to collect, analyze and submit or share health related The objective of this paper is two-fold: First, to explore the design principle behind progress-based strategy for user engagement in mHealth participatory sensing system. Second, to propose myCommHealth, a proof-of-concept prototype that incorporate intrinsic incentive, feedback, and self-monitoring tools to improve user participation in wellness and health-maintenance campaign.
[Independent risk factors for severity and mortality in lower gastrointestinal bleeding].

In lower gastrointestinal bleeding (LGIB), it is very important to stratify the risk of LGIB for a proper management. OBJECTIVE Identity the independent risk factors to mortality and severity (require critical care, prolonged hospitalization, reebleding, re hospitalization, politrasfusion, surgery for bleeding control) in LGIB. MATERIALS AND METHODS It is an analytic prospective cohort study, performed between June 2016 and April 2018 in a tertiary care hospital. Independent factors were determined using binomial logistic regression. RESULTS A total of 98 patients were included, of which 13 patients (13,3%) died, and 56 (57,1%) met severity criteria. The independent risk factor for mortality was Glasgow scale under 15, and for severe bleeding were: Systolic blood pressure under 100 mm Hg, albumin lower than 2,8 g/dL. CONCLUSIONS The frequency of mortality and severe LGIB is high in our population, the principal risk factors were systolic blood pressure under than 100 mm Hg, Glasgow score lower than 15, albumin lower than 2,8 g/dL. Identifying these associated factors would improve the management of LGB in the emergency room.
International travel as risk factor for Chlamydia trachomatis infections among young heterosexuals attending a sexual health clinic in Melbourne, Australia, 2007 to 2017

Background International travel is considered a risk factor for acquiring Chlamydia trachomatis; however, there are little empirical data to support this. Aim To examine the prevalence and risk factors for Chlamydia trachomatis infections among heterosexual international travellers (n = 28,786) attending the Melbourne Sexual Health Centre (MSHC), Australia, compared to Australian residents (n = 20,614). Methods We conducted a repeated cross-sectional study and analysed sexual behaviours and chlamydia positivity among heterosexual males and females aged ≤ 30 attending MSHC for the first time between January 2007 and February 2017. ‘Travellers’ were defined as individuals born outside of Australia who had resided in the country < 2 years. Associations between patient characteristics and chlamydia positivity were examined. Results Chlamydia positivity was higher among travellers (11.2%) compared with Australian residents (8.5%; p < 0.001). Male travellers had higher chlamydia positivity (12.1%) than Australian males (9.3%; p < 0.001), as did female travellers (10.4%) compared with Australian females (7.7%; p < 0.001). Travellers had a higher mean number of sexual partners than Australian residents among males (5.7 vs 4.7; p < 0.001) and females (3.6 vs 3.2; p < 0.001). Travellers from the United Kingdom, Europe, Ireland and New Zealand accounted for 29.6%, 21%, 8.5% and 5.8% of C. trachomatis infections, respectively. Chlamydia in males and females was associated with younger age (≤ 25), inconsistent condom use, a higher number of sexual partners (≥ 4 partners) and being a traveller (p < 0.001). Conclusions We found that international travel is an independent risk factor for chlamydia among young heterosexual travellers in Australia, who should therefore be a target group for chlamydia prevention.
An oxygen-controlled in vitro model of the gastrointestinal human-microbiome interface

The gastrointestinal system plays a vital role in the functioning of the human body, processing food into useable energy, controlling homeostasis, and serving as the front line of the immune system. The intestines are aided in their many functions by the gut microbiome, a collection of 100 trillion anaerobic bacteria cells that live inside the GI tract. Although they play an essential part in the organ system, they remain little-represented in in vitro gastrointestinal models because of the difficulty of replicating the anaerobic conditions of the intestines. We constructed an in vitro model capable of growing aerobic epithelial intestinal cells along with anaerobic microbes in the same bioreactor. A device called the apical flow module seals a 12-well transwell and provides an inlet and outlet port into the apical chamber. Media is deoxygenated using nitrogen bubbles before it is pumped using a nitrogen-actuated pneumatic pump block. Microbes are injected into the anaerobic fluid through a rubber septum injection port before the fluid flows into the sealed transwell. Effluent is collected in sterile tubes at a controlled height so as to regulate the apical side pressure. Oxygen is provided to the basolateral human epithelial cells through basolateral circulation achieved using a pneumatic circulation plate. Preliminary testing confirms our ability to control the oxygen in all parts of the system and to grow cocultures of human and bacteria cells. Epithelial cells grown in our bioreactor show signs of behaving more similarly to cells in vivo when exposed to the conditions present in our system, providing researchers with an oxygen-controlled gastrointestinal in vitro model. Thesis Supervisor: David L. Trumper Title: Professor of Mechanical Engineering Thesis Supervisor: Linda G. Griffith Title: School of Engineering Professor of Teaching Innovation, Biological and Mechanical Engineering
pmoA based detection of methanotrophic bacteria in coal-bed rocks of the Lublin Coal basin

Methane is one of the most important greenhouse gases. In spite of its low mixing ratio (1775 ppbv), it is responsible for 20-30% of global warming. However, factors influencing methane fluxes to the atmosphere from different sources are still under debate. One of the most important elements of the methane cycle are methanotrophic bacteria. This unique group of Proteo- bacteria utilises methane at various levels, from atmospheric concentrations to several percentages, using molecular oxygen. Methanotrophs have been found in many terrestrial, aquatic and subsurface environments, there is however little information about methanotrophs connected with coal deposits. In the study, the presence of methanotrophic bacteria in coal-associated rocks of the Lublin Coal Basin (LCB) was confirmed by the methanotrophic activity tests of fresh and autoclaved samples from depths of 914 m and 997 m below the surface. Methanotrophs were also successfully enriched on nitrate minimal salts medium and identified based on the cloned pmoA sequences. It was found that methane-oxidising bacteria present in the LCB are highly similar to Methylosinus, Methylocys- tis and Methylocaldum species. It was assumed that biological oxidation may be one of the proc- esses influencing methane concentrations in coal-beds and that rocks excavated with coal may serve e.g. as methanotrophically active covers preventing CH4 emission from landfills.
Multi-Site Photoplethysmography Technology for Blood Pressure Assessment: Challenges and Recommendations

Hypertension is one of the most prevalent diseases and is often called the “silent killer” because there are usually no early symptoms. Hypertension is also associated with multiple morbidities, including chronic kidney disease and cardiovascular disease. Early detection and intervention are therefore important. The current routine method for diagnosing hypertension is done using a sphygmomanometer, which can only provide intermittent blood pressure readings and can be confounded by various factors, such as white coat hypertension, time of day, exercise, or stress. Consequently, there is an increasing need for a non-invasive, cuff-less, and continuous blood pressure monitoring device. Multi-site photoplethysmography (PPG) is a promising new technology that can measure a range of features of the pulse, including the pulse transit time of the arterial pulse wave, which can be used to continuously estimate arterial blood pressure. This is achieved by detecting the pulse wave at one body site location and measuring the time it takes for it to reach a second, distal location. The purpose of this review is to analyze the current research in multi-site PPG for blood pressure assessment and provide recommendations to guide future research. In a systematic search of the literature from January 2010 to January 2019, we found 13 papers that proposed novel methods using various two-channel PPG systems and signal processing techniques to acquire blood pressure using multi-site PPG that offered promising results. However, we also found a general lack of validation in terms of sample size and diversity of populations.
Waterbird use of different treatment stages in waste-stabilisation pond systems

Abstract The significance of waste-stabilisation ponds (WSPs) to waterbirds has been well documented, but WSP differ depending on their place and purpose in the sewage-treatment system, and there is little information on how birds use these different types of pond. In mid-winter (July) 2012, waterbirds were counted on WSP at 18 sewage-treatment plants in the Goulburn Valley, Victoria. Winter-storage and maturation ponds supported greater abundance, density (birds ha−1) and richness of waterbirds than aerated and anaerobic ponds. There were no significance differences in the number of species per hectare among types of pond. The abundance and density of diving waterfowl on maturation and winter-storage ponds was greater than on anaerobic and aerated ponds. A multivariate analysis revealed that waterbird community composition (based on both abundance and density) differed significantly between maturation ponds and anaerobic ponds (P <0.001) and also between winter-storage and anaerobic ponds (P <0.01). Comparing among types of WSPs, the waterbird communities of anaerobic ponds were the most distinct and winter-storage and maturation ponds the least different. Although the primary objective of a treatment plant is to treat sewage there is some design flexibility and, where possible, increasing the size or number of maturation and winter-storage ponds, or both, would generally benefit waterfowl.
Simulation toolkit for energy scavenging inertial micro power generators

A critical issue to the optimization of a micro generator is the electromechanical link between the transducer and power processing circuitry because the performance of each subsystem depends on the behavior of the other. In order to accurately simulate and optimize a micro generator system, a combined electromechanical simulation is required. In this paper, a PSpice based electromechanical simulation tool kit for energy harvesting inertial micro generators has been developed. The tool kit consists of a generic Mass-Spring-Damper (MSD) model coupled to models of Electromagnetic (EM), Electrostatic (ES) and Piezoelectric (PZ) transduction mechanisms. Additional features of the physical systems that affect the overall performance such as end stop dynamics and parasitic damping are also included. The realisation of these models in PSpice is explained and case study simulation results of these models are also presented. keywords: Energy scavenging, PSpice modeling, inertial micro generator
Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison of Mesoporous Silica Versus Hot Melt Extrusion Technologies

Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer-based amorphous formulations manufactured by spray drying, hot melt extrusion (HME), or co-precipitation are most common. However, these technologies have challenges in terms of the successful stabilization of poor glass former compounds in the amorphous form. An alternative approach is mesoporous silica, which stabilizes APIs in non-crystalline form via molecular adsorption inside nano-scale pores. In line with these considerations, two poor glass formers, haloperidol and carbamazepine, were formulated as polymer-based solid dispersion via HME and with mesoporous silica, and their stability was compared under accelerated conditions. Changes were monitored over three months with respect to solid-state form and dissolution. The results were supported by solid-state nuclear magnetic resonance spectroscopy (SS-NMR) and scanning electron microscopy (SEM). It was demonstrated that mesoporous silica was more successful than HME in the stabilization of the selected poor glass formers. While both drugs remained non-crystalline during the study using mesoporous silica, polymer-based HME formulations showed recrystallization after one week. Thus, mesoporous silica represents an attractive technology to extend the formulation toolbox to poorly soluble poor glass formers.
Functional outcomes after surgery for thumb carpometacarpal joint arthritis

There are a number of possible assessments of functional outcomes for thumb carpometacarpal joint arthritis. The most important and easiest to measure is pain, but it is not the only material outcome. Functional scores for measuring the outcome of the treatment of thumb carpometacarpal joint arthritis have been recommended for some time, but are still not widely used even in published studies. It is also unclear which functional scores are the most valuable. Easily used scores, such as the Disabilities of the Arm Shoulder and Hand questionnaire, are freely available, but may not be sensitive enough to assess outcomes especially of thumb carpometacarpal joint arthroplasty. The optimal functional outcome measurement would be weighted for the individual patient. A minimum dataset needs to be defined in order to compare studies and derive meaningful data.
Non-local mean value image de-noising algorithm based on self-adaption

In traditional non-local mean value algorithm, both filter parameters and measurement of search neighborhood are constant globally and it does not show diverse structural features of different areas in images, which makes the weight of similarity of image blocks distributed unreasonably, and thus de-noising can be not effective. In order to avoid that, a non-local mean value image de-noising algorithm based on self-adaption is pro-posed. With analysis of the content of image blocks, image blocks from different areas will obtain different filter parameters and search fields, which cause the similarity weights of image blocks a more proper distribution. Experimental results showed that the new algorithm, after de-noising, achieved an increase of peak signal to noise ratio of images and, at the same time, reserved details of images and marginal information effectively.
THE STATUS OF NONINVASIVE FUNCTIONAL ELECTRICAL STIMULATION AND AMBULATION PERFORMANCE FOR THORACIC- LEVEL COMPLETE PARAPLEGICS

This paper reviews of status of noninvasive (transcutaneous) functional electrical stimulation (FES) for the purpose of independent ambulation by spinal-cord injured (SCI) patients having complete thoracic-level spinal cord lesions, namely, patients having neither motor function nor sensation in their lower extremities. The paper reviews FES system design principles, criteria for patients admissibility to FES ambulation programs and training procedures. It provides data on ambulation performance and on subsequent medical benefits to patients who use a trascutaneous FES system. It also considers problems relating to system adoption and long term system use. Furthermore, the paper discusses regulatory approval and reimbursement aspects concerning the noninvasive FES systems for ambulation by paraplegics. The paper also compares non-invasive FES as with implanted FES systems and with long-leg braced hybrid systems for ambulation purposes, thoracic level SCI patients.
Diagnostic and mechanistic values of microRNA‐130a and microRNA‐203 in patients with papillary thyroid carcinoma

This research was determined to unearth the diagnostic values and the effects of microRNA (miR)‐130a and miR‐203 on cell proliferation and apoptosis of papillary thyroid carcinoma (PTC). Expression of miR‐130a and miR‐203 were evaluated and were subjected to correlation analysis. The diagnostic values of miR‐130a and miR‐203 and their associations with clinicopathological characteristics of patients with PTC were measured. The expression levels of miR‐130a and miR‐203 in K1, IHH4, TPC‐1, and BCPAP cells together with Nthy‐ori 3‐1 cells were measured. Cells were transfected with miR‐130a mimics, miR‐203 mimics, and coordinate of miR‐130a mimics and miR‐203 mimics. Cell growth, colony formation, and apoptosis were detected by cell counting kit‐8 (CCK‐8) assay, colony formation assay, and flow cytometry. PTC tissues had decreased miR‐130a and miR‐203 relative to adjacent normal tissues and normal thyroid tissue (both P < .05). miR‐130a was in positive correlation with miR‐203 (r = 0.754, P < .01). miR‐130a was related with tumor infiltration and tumor stage while miR‐203 was implicated in tumor stage and lymph‐node metastasis. The area under the curve (AUC), sensitivity, as well as specificity for miR‐130 in predicting PTC was 0.839, 74.5%, and 85.0% and those for miR‐203 were 0.818, 73.7%, and 84.0%, respectively. PTC cells had lower expression of miR‐130a and miR‐203 than that in Nthy‐ori 3‐1 cells. After transfected miR‐130a and miR‐203 mimics in BCPAP and TPC‐1 cells, both cells had increased miR‐130a and miR‐203, promoted cell apoptosis rate and decreased cell growth rate, and colony formation ability. After coordinately transfected with miR‐130a mimics and miR‐203 mimics, the cell growth and colony formation ability of PTC cells were restrained, and apoptosis of PTC cells was elevated (all P < .05). This study highlights that miR‐130a and miR‐203 have satisfactory diagnostic value in PTC and upregulated miR‐130a and miR‐203 can inhibit PTC cell growth and promote cell apoptosis.