Miracle-dz/UniFAR-FTUs huggingface dataset:
Alloactinosynnema iranicum sp. nov., a rare actinomycete isolated from a hypersaline wetland, and emended description of the genus Alloactinosynnema.

A Gram-staining-positive actinobacterial strain, Chem10(T), was isolated from soil around Inche-Broun hypersaline wetland in the north of Iran. Strain Chem10(T) was strictly aerobic, and catalase- and oxidase-positive. The isolate grew with 0-3 % NaCl, at 20-40 °C and at pH 6.0-8.0. The optimum temperature and pH for growth were 30 °C and pH 7.0, respectively. The cell wall of strain Chem10(T) contained meso-diaminopimelic acid as diamino acid and galactose, ribose and arabinose as whole-cell sugars. The polar lipid pattern contained diphosphatidylglycerol, phosphatidylglycerol and phosphatidylethanolamine. Strain Chem10(T) synthesized cellular fatty acids of the straight-chain saturated and mono-unsaturated, and iso- and anteiso-branched types C14 : 0, C16 : 0, iso-C16 : 1, anteiso-C17 : 0, iso-C16 : 0, iso-C14 : 0 and iso-C15 : 0, and the major respiratory quinone was MK-9(H4). The G+C content of the genomic DNA was 70.7 mol%. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain Chem10(T) belonged to the family Pseudonocardiaceae and showed the closest phylogenetic similarity to Alloactinosynnema album KCTC 19294(T) (98.3 %) and Actinokineospora cibodasensis DSM 45658(T) (97.9 %). DNA-DNA relatedness values between the novel strain and strains Alloactinosynnema album KCTC 19294(T) and Actinokineospora cibodasensis DSM 45658(T) were only 52 % and 23 %, respectively. On the basis of phylogenetic analysis, phenotypic characteristics and DNA-DNA hybridization data, a novel species of the genus Alloactinosynnema is proposed, Alloactinosynnema iranicum sp. nov. The type strain is Chem10(T) ( = IBRC-M 10403(T) = CECT 8209(T)). In addition, an emended description of the genus Alloactinosynnema is proposed.
Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search

Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.
Dietary supplements and health

Dietary supplements can contain a wide variety of ingredients, either singly or in combination, including nutrients, botanicals and 'bioactive components' commonly found in foods. They are marketed and used by consumers for a range of reasons: to enhance "wellbeing", as traditional medicines, for health promotion or disease risk reduction, and as alternatives or complements to conventional drug therapies.
Arterial Resection During Pancreatectomy for Pancreatic Cancer: A Systematic Review and Meta-Analysis

Background:The majority of pancreatic cancers are diagnosed at an advanced stage. As surgical resection remains the only hope for cure, more aggressive surgical approaches have been advocated to increase resection rates. Institutions have begun to release data on their experience with pancreatectomy and simultaneous arterial resection (AR), which has traditionally been considered a general contraindication to resection. The aim of the present meta-analysis was to evaluate the perioperative and long-term outcomes of patients with AR during pancreatectomy for pancreatic cancer. Methods:The Medline, Embase, and Cochrane Library and J-East databases were systematically searched to identify studies reporting outcome of patients who underwent pancreatectomy with AR for pancreatic cancer. Studies that reported perioperative and/or long-term results after pancreatectomy with AR were eligible for inclusion. Meta-analyses included comparative studies providing data on patients with and without AR and were performed using a random effects model. Results:The literature search identified 26 studies including 366 and 2243 patients who underwent pancreatectomy with and without AR. All studies were retrospective cohort studies and the methodological quality was moderate to low. Meta-analyses revealed AR to be associated with a significantly increased risk for perioperative mortality [Odds ratio (OR) = 5.04; 95% confidence interval (CI), 2.69–9.45; P < 0.0001; I2 = 24%], poor survival at 1 year (OR = 0.49; 95% CI, 0.31–0.78; P = 0.002; I2 = 35%) and 3 years (OR = 0.39; 95% CI, 0.17–0.86; P = 0.02; I2 = 49%) compared with patients without AR. The increased perioperative mortality (OR = 8.87; 95% CI, 3.40–23.13; P < 0.0001; I2 = 5%) and lower survival rate at 1 year (OR = 0.50; 95% CI, 0.31–0.82; P = 0.006; I2 = 40%) was confirmed in the comparison to patients undergoing venous resection. Despite substantial perioperative mortality, pancreatectomy with AR was associated with more favorable survival compared with patients who did not undergo resection for locally advanced disease. Conclusions:AR in patients undergoing pancreatectomy for pancreatic cancer is associated with a poor short and long-term outcome. Pancreatectomy with AR may, however, be justified in highly selected patients owing to the potential survival benefit compared with patients without resection. These patients should be treated within the bounds of clinical trials to assess outcomes after AR in the era of modern pancreatic surgery and multimodal therapy.
THE SOCIAL PERCEPTION OF FACES 97 SECTION I : THE SPECIAL STATUS

Faces are one of the most potent social stimuli conveying information about social categories (e.g., sex, age, race), mental states (e.g., puzzled), emotional states (e.g., angry), attractiveness, and identity. People also infer a host of personality characteristics from facial appearance such as trustworthiness and competence (Todorov, Said, & Verosky, 2011), although these inferences are not necessarily accurate (Olivola & Todorov, 2010a). People can rapidly extract information from faces about:
T-2 toxin and diacetoxyscirpenol metabolism by Baccharis spp

Hybrids resulting from crosses between Baccharis sarothroides and B. pilularis (FS1), B. sarothroides (FS2) and B. megapotamica (FS3) were tested for their tolerance to trichothecenes as well as their ability to metabolize the toxins. B. sarothroides (desert broom) was placed in an aqueous solution containing 500 ppm of T-2 toxin and showed visible signs of toxicity on the twigs at 21 h after exposure but not at 6 h, indicating some resistance. Samples of the twigs harvested 6 and 21 h after treatment contained, respectively, T-2 (0.03 and 2.2 micrograms/g), HT-2 (0.09 and 7.6 micrograms/g), and T-2-tetraol (2.1 and 2.6 micrograms/g). The hybrid FS1 showed no signs of toxicity 6 h after treatment, and its twigs contained T-2 (0.8 micrograms/g), HT-2 (10.2 micrograms/g), and T-2-tetraol (10.8 micrograms/g). The leaves at 6 h contained 0.5 micrograms of T-2, 1.7 micrograms of HT-2, 0.01 microgram of 3'-hydroxy-HT-2, and 41 micrograms of T-2-tetraol per g. At 21 h, toxic signs were apparent and the twigs contained T-2 (39 micrograms/g), HT-2 (62 micrograms/g), 3'-hydroxy-HT-2 (0.8 microgram/g), and T-2-tetraol (22 micrograms/g). (ABSTRACT TRUNCATED AT 250 WORDS)
Human Teratogens and Evidence-based Teratogen Risk Counseling: The Motherisk Approach

There are only a limited number of drugs proven to be human teratogens including thalidomide, isotretinoin, coumarin derivates, valproic acid, and folate antagonists. In some cases, the combination of 2 drugs may increase the teratogenic risk. The risk of birth defects may also vary with the time at which the drug is administered during pregnancy and the dose. There are some examples of drugs in which the dose has proven to be a major determinant of their teratogenicity in humans. There is more safety information for older than for newer drugs. Proactive teratogen risk counseling should include a critical appraisal of all available data including the consequences of the untreated maternal condition.
Growth of Au-assisted GaAs/AlGaAs core-shell nanowires by metalorganic chemical vapor deposition

Growth and characterization of GaAs/AlGaAs core-shell nanowires (NWs) are reported. Using the VLS (vapor-liquid-solid) mechanism, GaAs NWs oriented perpendicularly to the substrate were grown on GaAs (111) B substrate. Using the metalorganic chemical vapor deposition (MOCVD) growth mode, AlGaAs shells were grown on GaAs NWs sidewalls. Single crystal and pure zinc-blende structure are achieved for GaAs NWs. It is founded that the zinc-blende phase is also the dominant phase for GaAs/AlGaAs core-shell NWs with some defects. This study on GaAs/AlGaAs core-shell NWs has many potential applications for nano-electronic and nano-optoelectronic devices.
Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP/vasoactive intestinal polypeptide receptors: actions on the anterior pituitary gland.

I. Introduction PITUITARY adenylate cyclase activating polypeptide (PACAP) was first isolated from ovine hypothalamus by its potent activity in stimulating cAMP production in rat anterior pituitary cells (1). Since its isolation a wealth of literature has been published describing its activity in a variety of tissues including pituitary, brain, adrenal, testis, and in the nerve fibers of both the gut and the lung. A number of reviews have discussed its actions in a variety of cell types (2–4), its binding sites (5), and the characteristics of the three PACAP receptors cloned to date, two of which it apparently shares with vasoactive intestinal polypeptide (VIP) (4, 6, 7). The present review will deal specifically with the putative role of PACAP as a hypophysiotropic factor regulating anterior pituitary cell activity: This review begins with a brief history of PACAP and a description of its structure and its receptors. We will then discuss the distribution of PACAP in the hypothalamus, which suggests its r.
Reliability impacts of climate change initiatives

Climate change initiatives proposed by governments and industry organizations have the potential for reallocating trillions of dollars, affecting the way energy is used. The aggressiveness or pace of mandates/targets could lead to different near-term and long-term outcomes, as well as diverse supply-demand for fuel commodities, technology deployments, and cost considerations.
Hypogonadotrophic hypogonadism in type 2 diabetes

Recent work shows a high prevalence of low testosterone and inappropriately low luteinizing hormone (LH) and follicle stimulating hormone (FSH) concentrations in type 2 diabetes. This syndrome of hypogonadotrophic hypogonadism (HH) is associated with obesity in patients with type 2 diabetes. However, the duration of diabetes or HbA1c are not related to HH. Furthermore, recent data show that HH is not associated with type 1 diabetes. C-reactive protein concentrations have been shown to be elevated in patients with HH and are inversely related to plasma testosterone concentrations. This inverse relationship between plasma free testosterone and C- reactive protein concentrations in patients with type 2 diabetes suggests that inflammation may play an important role in the pathogenesis of this syndrome. This is of interest since inflammatory mechanisms may have a cardinal role in the pathogenesis of insulin resistance. It is also relevant that in the mouse, deletion of the insulin receptor in neurons leads to HH in addition to a state of systemic insulin resistance. It has also been shown that insulin facilitates the secretion of gonadotrophin releasing hormone (GnRH) from neuronal cell cultures. Thus, HH may be the result of insulin resistance at the level of the GnRH secreting neuron. Low testosterone concentrations are also related to an increase in total and regional adiposity. This review discusses these issues and attempts to make the syndrome relevant as a clinical entity. Clinical trials are required to determine whether testosterone replacement alleviates insulin resistance and inflammation. In addition, low testosterone levels are associated with an increase in cardiovascular events. Testosterone therapy may therefore, reduce cardiovascular risk. This important aspect requires further investigation.
Development of a Computer-Based Instructional Design tool-Analysis and Design Phases

This paper discusses the computerization of an existent tool called GRASP. It helps teachers to design an instructional system. Currently, GRASP has the form of a grid. Teachers complete it to first clarify their instructional problem and then to design an instructional system. This tool covers the analysis and design phases of the ADDIE (Analyze, Design, Develop, Implement and Evaluate) model. GRASP has been validated in a two-phase evaluation. The paper discusses the pertinence and the adequate way to realize the computerization of GRASP; the proposed system is called CBGRASP. For this, the paper begins with the context of the work. Then a review literature informs about instructional design. GRASP and its use are then described. The analysis and design phases of CB-GRASP are presented. The perspectives of this work conclude this paper.
Properties of the Grasp Stiffness Matrix and Conservative Control Strategies

In this paper, we present fundamental properties of stiffness matrices as applied in analysis of grasping and dextrous manipulation in configuration spaces and linear Euclidean R3×3 space without rotational components. A conservative-stiffness matrix in such spaces needs to satisfy both symmetric and exact differential criteria. Two types of stiffness matrices are discussed: constant and configuration-dependent matrices. The symmetric part of a constant-stiffness matrix can be derived from a conservative quadratic potential function in the Hermitian form; while the skew-symmetric part is a function of the nonconservative curl vector field of the grasp. A configuration-dependent stiffness matrix needs to be symmetric and must simultaneously satisfy the exact differential condition to be conservative. The theory is most relevant to the Cartesian stiffness control, where the stiffness of the end effector is usually constant, such as that in RCC wrists. Conservative control strategies are proposed for a configuration-dependent stiffness matrix. One of the most important results of this paper is the nonconservative congruence mapping of stiffness between the joint and Cartesian spaces. In general, the congruence transformation (or its inverse transformation), Kθ = JT θKpJθ, is a nonconservative mapping over finite paths for a configuration-dependent Jacobian. Thus, to obtain a conservative system with respect to the Cartesian space, one has to either find the corresponding Kθ at every configuration due to the constant and symmetric Cartesian stiffness matrix, or determine the symmetric yet configuration-varying Kθ which makes the resulting configuration-dependent Kp conservative. In addition, the stiffness matrix also must be positive definite to maintain stability.
Developmental Changes in the Sterol Composition and the Glycerol Content of Cuticular and Internal Lipids of Three Species of Flies

The glycerol concentration and the composition of cuticular and internal sterols in three medically and forensically important fly species, viz., Musca domestica, Sarcophaga carnaria, and Calliphora vicina, were analyzed. The cuticular and internal lipid extracts were separated by HPLC‐LLSD, after which the sterol fraction was characterized by GC/MS in total ion current (TIC) mode. The cuticular lipids of M. domestica larvae contained seven sterols, while in pupae and females, six sterols were identified. Five sterols were found in the cuticular lipids of M. domestica males. The internal lipids of M. domestica larvae and pupae contained six and seven sterols, respectively, while those of male and female flies contained only five sterols. Sitosterol, cholesterol, and campesterol were the dominant sterols in M. domestica, while campestanol, stigmasterol, sitostanol, and fucosterol were identified in low concentrations or in traces. In contrast, cuticular and internal lipids of S. carnaria and C. vicina contained only cholesterol. Glycerol was identified in all stages of M. domestica, S. carnaria, and C. vicina. For all the three examined fly species, the present study clearly showed species‐specific developmental changes in the composition of cuticular and internal sterols as well as in the glycerol concentration.
Events recognition by semantic inference for sports video

In this paper, we propose a knowledge-based semantic inference scheme for events recognition in sports video. The framework includes three layers. At the bottom layer, low-level features are extracted at the frame level and semantic clips are segmented. Then we map the semantic clips to semantic concepts by a neural network and decision-tree at the second layer. Finally, semantic inference toward events recognition is performed on the predefined finite-state machine models at the top layer. The effectiveness and efficiency of our approach are demonstrated by the experimental results on events recognition in track and field videos.
Think Small: Nanotechnology for Plastic Surgeons

Abstract The purpose of this article is to introduce the topic of nanotechnology to plastic surgeons and to discuss its relevance to medicine in general and plastic surgery in particular. Nanotechnology will be defined, and some important historical milestones discussed. Common applications of nanotechnology in various medical and surgical subspecialties will be reviewed. Future applications of nanotechnology to plastic surgery will be examined. Finally, the critical field of nanotoxicology and the safe use of nanotechnology in medicine and plastic surgery will be addressed.
Robust H∞ disturbance attenuation for a class of uncertain discrete-time fuzzy systems

This paper is concerned with robust stabilization and control of a class of uncertain discrete-time fuzzy systems. The class of uncertain systems is described by a state space Takagi-Sugeno (TS) fuzzy models with linear nominal parts and norm-bounded parameter uncertainties in the state and output equations. First, a sufficient condition on robust stability of the fuzzy models is proposed. Then, -disturbance attenuation performance of the fuzzy models is analyzed. Some sufficient conditions are derived on robust -disturbance attenuation in which both robust stability and a prescribed performance are required to be achieved, irrespective of the uncertainties. Numerical example shows the use of the results on the stabilization and -disturbance attenuation of a class of discrete-time nonlinear systems via fuzzy switch.
Static and dynamic light scattering from aggregating particles.

We use standard hydrodynamic and light scattering theories to calculate the total intensity and dynamic light scattering properties of random aggregates of spherical particles containing up to ten spheres. When the aggregates have dimensions comparable to the wavelength of light, intraaggregate interference effects can dramatically reduce the apparent size of the aggregates. These results could be significant in interpreting DNA condensation, protein polymerization, and other biomolecular aggregation reactions.
Treatment of Calcifying Tendinitis of the Shoulder With Shock Wave Therapy

In a prospective clinical study, the effectiveness of shock wave treatment for calcifying tendinitis in 31 shoulders in 29 patients (14 women and 15 men) with an average age of 52 years was assessed. Each shoulder was treated with 1000 impulses of shock waves at 14 kV. A 100-point Constant score system was used for evaluation. The overall results of 20 patients (21 shoulders) with 12 weeks followup were no complaints in 23.8%, significantly improved in 38.1%, some improvement in 14.3%, and unchanged in 23.8%. Considerable improvement was observed between 6 and 12 weeks. The results of seven patients with 24 weeks followup were no complaints in two patients, significantly improved in three, and unchanged in two patients. Radiographs showed complete elimination of the calcium deposits in six patients (28.6%), incomplete elimination in two patients (9.5%), and three patients (14.3%) had fragmentation of the calcium deposits. There was no recurrence of calcium deposits observed at 24 weeks. There was a correlation between the functional improvement and the elimination of calcium deposits. There were no device-related problems, systemic or local complications. Low-energy shock wave therapy may offer a new and safer additional nonoperative treatment for patients with calcifying tendinitis of the shoulder.
Plasma levels of remnant particles are determined in part by variation in the APOC3 gene insulin response element and the APOCI-APOE cluster.

Remnant particles of triglyceride-rich lipoproteins (RLP) are known to be a strong predictor of atherogenicity. The serum concentrations of remnant-like particle triglyceride (RLPTG) and remnant-like particle cholesterol (RLPC) have been determined in a representative sample of the Czech MONICA study (n = 285). The relationship was investigated between remnant particle triglyceride/cholesterol concentrations and polymorphisms in the genes APOC3 (-482C-->T/3238C-->G), APOE (epsilon2/epsilon3/epsilon4), APOCI (-317-321ins), APOB (signal peptide), hepatic lipase (LIPE, -480C-->T), and lipoprotein lipase (LPL, S447X). Univariate analysis showed significant effects on RLPTG associated only with the APOE genotype (P = 0.009), the APOC3 -482C-->T genotype (P = 0.018), and the APOCI -317-321ins (P = 0.014) genotype and significant effects on RLPC with APOE (P = 0.01) and APOCI -317-321ins (P = 0.021). The raising effect of the APOE genotype for both remnant cholesterol and triglyceride was confined to the epsilon2/4 (n = 6) and varepsilon4/4 (n = 3) groups, and thus when the epsilon2/4 group was omitted in order to analyze by allele (epsilon2+/epsilon3+/epsilon4+), significance was lost (P = 0.6). There was strong linkage disequilibrium between the APOE and APOCI alleles (chi(2), P < 0.001) and a multivariate ANOVA of RLPTG with all three significantly associated variants as factors demonstrated that while the APOC3 -482C-->T effect was independent of the others (P = 0.003), the APOCI -317-321ins and APOE effects were not. This was also true for the APOCI -317-321ins and APOE effects on RLPC. To assess whether APOE-CI effects on RLPC were independent of their effects on total cholesterol and triglyceride levels, multiple linear regression was used. Using multiple linear regression, it appeared that the APOE-CI effects on RLPC were independent of their effects on plasma cholesterol, but the effects of APOC3 and APOE-CI on RLPTG could not be separated from their effects on plasma Tg levels. Further characterization of this remnant particle phenotype and its genetic determinants may lead to a better understanding of its metabolism and contribution to atherosclerosis.