Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Gender on the Outcome of Coronary Artery Bypass Surgery: A Report From The Thai National Cardiac Surgical Database

Women undergoing coronary artery bypass graft (CABG) surgery remain at a higher risk for operative mortality than men. The aim of this study was to assess the effect of gender on mortality and morbidity following coronary artery bypass surgery. Methods: CABG surgery was performed in 137 patients, of which 41 (29.9%) were female during the 2006 year. Results were analyzed for numerous variables including mortality, morbidity and other perioperative events. The effect of gender was specifically examined. Results: In the 2006 year, there were 137 patients who underwent coronary artery bypass surgery. Women (n = 41) were older (64.7 ± 9.8 versus 61.9 ± 9.5; p = 0.011) and a large percent of them were over 70 years of age (31.7% versus 16.7%; p < 0.001) when compared to men. They had also a higher prevalence of diabetes (65.9% versus 33.3%; p<0.001) and a smaller body surface area than men (1.52 ± 0.13 versus 1.72 ± 0.14; p < 0.001). Internal mammary artery usage was 95.1% among women and 100% in men. Overall mortality was 2.9% (4 of 137 patients). Men were prone to perioperative myocardial infarction (0% versus 4.2%, p = 0.252). After adjustment for other risk variables, perioperative myocardial infarction was a predictor for mortality (odds ratio, 87.33; 95% confidence interval, 6.113 to 1247.697; p = 0.001) Conclusions: Although preoperative risks and comorbidity were higher in women presenting for CABG surgery, there were no significant differences in clinical outcomes between men and women.
EVALUACIÓN DEL RIESGO DE INFECCIONES ALIMENTARIAS EN PACIENTES INTERNADOS EN UN HOSPITAL PEDIÁTRICO DE ALTA COMPLEJIDAD Y SU SISTEMA DE PREVENCIÓN RISK ASSESSMENT OF FOOD INFECTIONS IN PATIENTS IN A PEDIATRIC TERTIARY-CARE HOSPITAL AND ITS PREVENTION

The Garrahan Hospital is a tertiary-care center for pediatrics patients with complex diseases. Infections, including food-borne infections, contribute considerably to the morbidity and mortality in this population at risk. In order to prevent food-borne infections, the Foodservice Area has developed a preventive process approach system of Hazard Analysis and Critical Control Point (process approach HACCP) in food production and service. Objective: To conduct a thorough review and assessment of risk from foodborne pathogens according to the pathology of patients or the therapeutic practice used, and to standardize food production and service. With the criterion “degree of safety at the time of service” preventive measures were standardized. The food was classified into four levels of process. One or more food levels are indicated according to risk, and if necessary individual adjustments are made.
Pharmacotherapy of vertigo

Pharmacotherapy of vertigo can be symptomatic or specific. There is no ideal drug for the management of vertigo. Acute vertigo is usually managed with vestibular suppressants and antiemetic medications. Anticholinergics, antihistamines, dopaminergic antagonists, and monaminergics are most often used in the treatment of vertigo and associated symptoms. Some other drugs are also used in its treatment. However, vertigo is a subjective feeling which makes it difficult to measure the drug effect. Therefore, many papers dealing with vertigo treatment suffer from methodological pitfalls, making it difficult to establish a generally acceptable consensus about the treatment of vertigo.
Original article: HEPATOPROTECTIVE ACTIVITY OF CINNAMON ETHANOLIC EXTRACT AGAINST CCL4-INDUCED LIVER INJURY IN RATS

The inner bark of cinnamon (Cinnamomum zeylanicum L.) is commonly used as a spice and has also been widely employed in the treatment and prevention of disease. The aim of the present study is to evaluate the protective effect of cinnamon bark extract against carbon tetrachloride (CCl4)-induced liver damage in male Wistar rats. Administration with cinnamon extracts (0.01, 0.05 and 0.1 g/kg) for 28 days significantly reduced the impact of CCl4 toxicity on the serum markers of liver damage, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase. In addition, treatment of cinnamon extract resulted in markedly increased the levels of superoxide dismutase and catalase enzymes in rats. The histopathological studies in the liver of rats also supported that cinnamon extract markedly reduced the toxicity of CCl4 and preserved the histoarchitecture of the liver tissue to near normal. Thus, the results suggest that cinnamon extract acts as a potent hepatoprotective agent against CCl4 induced hepatotoxicity in rats.
Cleansers: To use or not to

Cleansers are agents responsible of cleansing the skin to get rid of the dust, dirt, sebum, and dead cells accumulated as a part of normal desquamation process. Cleanser technology has come a long way from the traditional soaps and detergents to the more modernized liquid cleansing agents and syndets. They have thereby helped in reducing the side-effect potentials of cleansers and improved the beneficial effects. Addition of newer molecules helps in maintaining the skin barrier integrity and moisture on the skin. However, although the bright side of cleansers shines there is a gray zone of controversies regarding its usage. Discrepancy between the claims and evidences herewith make it imperative to consider the pros and cons. This article aims at summarizing the points in favor and against the usage of cleansers.
Erectile function improvement after endovenous varicosis therapy of the great saphenous vein Verbesserte Erektionsfähigkeit nach Laserablation der Vena saphena magna

Summary There are no cases reported about endovascular varicosis therapy having an impact on the erectile function of the man. This case reports’ patient had a stronger erection in the area of the glans penis after he underwent endovenous lasertherapy of the great saphenous vein. This effect could also be explained with the anatomy of the veins because some of the blood of the penis is drained by the external pudendal vein which leads into the saphenofemoral junction. If there is a manipulation on the veins of the saphenofemoral junction it might have an impact on the drainage of the penis. Zusammenfassung Über Auswirkungen von varizenausschaltenden operativen Eingriffen auf die Erektionsfähigkeit des Mannes ist bisher wenig bekannt. Der Bericht eines Patienten, der nach einer Laserablation der Vena saphena magna eine verbesserte Erektion der Glans penis feststellte, lässt allerdings die Überlegung zu, ob es in manchen Fällen einen Zusammenhang zwischen diesem Eingriff und Veränderungen bei der Erektion geben kann. Auch anatomisch ließe sich der Effekt eventuell erklären, da ein Teil des Blutes des Penis über die Vena pudenda externa in den Venenstern abfließt. Bei Interventionen, die den Venenstern bzw. die Vena saphena magna, die in den Venenstern mündet, betreffen, könnte es zu Änderungen der Flussverhältnisse innerhalb der Vena pudenda externa und somit auch des Penis kommen.
Meningitt ved reaktivering av varicella zoster-virus

Interessekonflikter: Ingen Varicella zoster-virus (VZV) er et membrankledd DNA-virus i samme underfamilie av herpesvirusfamilien som herpes simplexvirus type 1 og 2 (alfaherpesvirus). I likhet med øvrige herpesvirus har det evnen til å etablere latent infeksjon og forbli i verten resten av livet. Varicella zoster-virus gir primærinfeksjon i form av varicella (vannkopper). Det finnes deretter latent i hjernenerveog dorsalrotsganglier og kan senere reaktiveres (1). Vanligvis vil reaktivering av varicella zoster-virus gi hudmanifestasjon i form av zoster (helvetesild), eventuelt i kombinasjon med nevrologiske eller andre manifestasjoner (2). Påvisning av viruset i spinalvæske med polymerasekjedereaksjon (PCR) avdekker i økende grad nevrologiske manifestasjoner også uten samtidig zoster (1). Ofte reaktiveres varicella zoster-virus pga. immunsvikt eller høy alder, men reaktivering forekommer også hos immunkompetente (3). Myelitt og encefalitt er velkjente, men hittil oppfattet som sjeldne manifestasjoner ved reaktivering av varicella zoster-virus (1). Ved Folkehelseinstituttet ble det i perioden 1991–94 gjort laboratoriefunn forenlig med VZV-encefalitt hos åtte pasienter (4). Alle hadde samtidig zoster, og gjennomsnittsalderen var 65 år. Meningitt har tidligere vært beskrevet som en meget sjelden tilstand ved reaktivering, og da hos immunsvekkede (1). Nyere PCR-undersøkelser av spinalvæske i større pasientmaterialer i andre land har imidlertid vist at varicella zoster-virus, Epstein-Barrvirus og cytomegalovirus oftere forårsaker meningitt, encefalitt og encefalopati enn man tidligere har erkjent, også hos immunkompetente (3). Vi ønsket å undersøke om det ble gjort tilsvarende funn her i landet. Her omtales våre funn av varicella zostervirus i spinalvæske i en treårsperiode. Vi diskuterer reaktivert VZV-infeksjon i sentralnervesystemet hos immunkompetente personer. Reaktivering av varicella zoster-virus som årsak til serøs meningitt belyses med to kasuistikker.
Detection of Chlamydia Trachomatis among Infected Women

Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection (STI). C. trachomatis has a high rate of asymptomatic infection; approximately 80% of cases in females and 45% in males are estimated to be asymptomatic. The aim o f this study was to estimate the prevalence of C. trachomatis among women with chronic cervicitis, abortion, full term pregnancy and infertile women and compare between different methods of diagnosis for detection of C. trachomatis. Eighty women were subjected to our study, they were classified as 20 women with chronic mucopurulent cervicitis, 20 women with spontaneous abortion, 20 infertile and 20 full term pregnancy, also 40 controls normal women were examined. Endocervical specimens and blood samples were taken from all previous groups and subjected to examination ELISA for detecting Chlamydia trachomatis (C. trachomatis) antigen and immunoglobulin A (IgA). IgA and C. trachomatis ELISA gave positive chlamydial infection of 25% and 20%, respectively. IgA proved good sensitivity and specificity of 93.8% and 92.8%, respectively. Chlamydial infection was detected among 30% of abortion cases, 25% among infertile women, 15% among chronic mucopurulent cervicitis, 10% in full term pregnancy and 5% of the control women. C. trachomatis infection was significantly prevalent among examined cases in comparison to controls (P<0.05). Our results revealed increased incidence of chlamydial infection among nulliparous women but non statistical significant differences were recorded. Also, chlamydial infection was inversely related to young and marital duration less than 5 years, significant statistical differences were recorded (P<0.004 and <0.001) respectively. Chlamydial trachomatis has an important role especially in infertile women and those with spontaneous abortion. Cases of abnormal vaginal discharge particularly in young sexually active women belonging to low socioeconomic classes should be considered as at high risk of chlamydial infections. So, strategies for th treatment of females early in pregnancy must be carried. IgA and ELISA testes are sensitive methods of diagnosis of C. trachomatis.
Modelos de clasificación basados en máquinas de vectores soporte

En este trabajo se presentan las caracteŕısticas más importantes de los modelos de clasificación basados en máquinas de vectores soporte (SVMSupport Vector Machines). Las máquinas de vectores soporte son sistemas de aprendizaje que utilizan como espacio de hipótesis, funciones lineales en espacios caracteŕısticos de dimensión muy alta, ensayando algoritmos de aprendizaje de la teoŕıa de la optimización que implementan un aprendizaje sesgado derivado a partir de la teoŕıa del aprendizaje estad́ıstico. Algunas de las caracteŕısticas de estos modelos tienen una especial significación en problemas de clasificación de corte económico y en este trabajo se presentan y comentan.
ORIGINAL STUDY MANAGEMENT OF PHARYNGOLARYNGEAL REFLUX AT VOICE PROFESSIONALS

The development of specific programs for preventing dysphonia at voice professionals is necessary, including dysphonia caused by extraesophageal reflu x. The purpose of this study was to evaluate the ro le of pHmonitoring and PPI treatment for professional voi ces with LPR symptomatology. We included in our prospective study 96 patients, professional voices, all of them fulfilled the inclusion criteria and underwent laryngofiberscopy, pHmonitoring, before and after 2 month PPI (proton pump inhibitor) treatment (omeprazole) . We appied two questionnaires: RFS(Ref lux Finding Score) and RSI (Reflux Symptom Index). The distribution according to profession showed a signi ficant predominance of teaching profession, followe d by professional singers (p<0.05). For the RFS score, t he median value before treatment was 16.9(± 8.9) an d after treatment was 8 (±6.2) (p<0.05) The median value fo r the RSI score was 20.9 (+/- 9.6)before treatment ;after treatment was 12.8 (+/-10.0) (p<0.05). (table 7) Aft er two months of PPI treatment, 71.87% of patients registered an improvement of clinical symptoms or e ven healing of laryngeal lesions. After PPI treatme nt, the control pH-monitoring revealed a statistical signif icant change in terms of total time exposure to aci d reflux (p=0.0571) and duration of exposure (mean, p=0.0617 ) The pH monitoring measurements revealed pathological values (pH<4) at 64.58% of patients, d emonstrating that not all patients with acid reflux laryngitis also have reflux esophagitis. Even our control grou p had impaired values of pH monitoring, close to st atistical significance. The response rate following the PPI t reatment was about 71.87%. In the literature the res ponse rate varies between 60 and 100%. Our study highligh t the variability of treatment response in patients with LPR (laryngopharyngeal reflux), the necessity of long t erm treatment (especially for those patients with s lesions)and the necessity of increasing the PPI’s d osage. The clinical diagnosis of reflux laryngitis is based upon patient’s symptoms and fiberoptic laryngeal ex amination. pH monitoring can be used as a diagnosti c tool when there is no improvement in patient condition a2 months of PPI treatment.
Wine, alcohol, polyphenols and cardiovascular disease

Excessive alcohol consumption is associated with increased morbidity and mortality as well as with labour and traffic accidents. However, current evidence suggests beneficial effects of moderate drinking on cardiovascular events including coronary heart disease, ischaemic stroke, peripheral arterial disease and congestive heart failure. The underlying mechanisms to explain these protective effects against coronary heart disease include an increase in high-density lipoprotein cholesterol and an increase in insulin sensitivity, and a decrease in platelet aggregation and circulating concentrations of fibrinogen. However, there are discrepancies regarding the specific effects of different types of beverages on the cardiovascular system, and also whether the possible protective effects of alcoholic beverages are due to their alcohol component (ethanol) or non-alcoholic products containing, mainly polyphenols. Recent randomised clinical trials have shown that wine, a polyphenol-rich alcoholic beverage, provides higher antioxidant and anti-inflammatory effects than some spirits such as gin, a polyphenol-free alcoholic beverage. In addition, dealcoholized red wine decreases blood pressure through a nitric oxide mediated mechanism, suggesting a protective effect of polyphenols on vascular function. Other studies performed in women have observed that daily doses of 15-20 g of alcohol as red wine are sufficient to elicit protective effects similar to those observed in men who consumed higher doses of wine. In conclusion, moderate consumption of wine exerts a protective effect on biomarkers related to the progression and development of atherosclerosis due to its alcoholic (ethanol) and non-alcoholic (polyphenols) content. Women are more sensitive to the beneficial effects of wine.
Comparison of Fennel and Chamomile extract and placebo in treatment of premenstrual syndrome and dysmenorrheal

Introduction: Premenstrual syndrome (PMS) and dysmenorrheal are experienced by majority of women in reproductive age and in 1% of the women it is severe enough to interfere with social interaction and work performance. Many investigations on treatment of this problem, in particular on treatment with chemical drugs, have been carried out. The aim in this study is to find whether or not herbaceous drugs such as Fennel and Chamomile, which are generally used in traditional medicine, are effective in treatment of dysmenorrheal and PMS. Methods: In this clinical trial study, 60 women over 16 years of age with a convincing history of premenstrual syndrome were randomly selected and their PMS and dysmenorrheal experiences were investigated in 5 menstruation cycles. During the 1st cycle, they didn’t take any medication, during the 2nd and 3rd cycles they took Fennel extract and during 4th and 5th cycles, they took Chamomile extract. After each cycle they completed a questionnaire containing 16 PMS symptoms. Friedman statistical test was used to compare the results from different cycles. P<0.05 was considered significant. Results: Based on the results, there was a significant difference between severity of symptoms in the control cycle, and other cycles in 3 of the 16 PMS symptoms (p<0.05). These three symptoms were pelvic and abdominal pains, fatigue and lethargy, depression and anger. As for other symptoms, the severity in the Fennel and Chamomile herbal drugs cycles was less than that of the control cycle, but this difference was not statistically significant. Conclusion: According to this study, Fennel and Chamomile are effective in reducing some PMS disorders. Fennel is more effective in pelvic and abdominal pain and depression but Chamomile is more effective in fatigue and lethargy
Evidence-Based Practice in Occupational Health Psychology. Current Status and Further Developments

The present paper discusses the status of evidence-based practice in Occupational Health Psychology (OHP). After several searches on large online databases, we have found that OHP papers that discuss interventions are less than 10% of the overall literature. Furthermore, quantitative reviews research that reports interventions on major OHP topics are generally absent. In the last part of the paper, we formulate some reccomendations for increasing the number of papers relevant for evidence-based practice in OHP.
Renal Resistive Index is Unsusceptible to Systemic Hemodynamics in Fluid Responsive Critically Ill Patients

35 ©Copyright 2020 by Turkish Society of Intensive Care Turkish Journal of Intensive Care published by Galenos Publishing House. ABSTRACT Objective: The primary goal of fluid resuscitation in critically ill patients is to improve oxygen delivery to ensure adequate organ perfusion. Little evidence is known about renal response to fluids in the acute phase, so renal monitoring after the fluid challenge is fundamental during critical care stay. This study aimed to evaluate changes in the renal resistive index (RRI) and to compare these changes with hemodynamic parameters after fluid challenge in fluid responsive critically ill patients. Materials and Methods: Thirty patients older than 18 years who underwent sedation and received mechanical ventilation were prospectively studied. Twenty patients were fluid responsive and were included in the study. An increase of cardiac output (CO) by 10% or more after PLR measured by ultrasonic CO monitor suspected fluid responsiveness. 500 mL of isotonic solution was administered intravenously for 30 minutes. CO measurements were performed at 0, 1 and 30 minutes. RRI and mean arterial pressure (MAP) were measured by Doppler ultrasonography at 0 and 30 minutes. Repeated measures ANOVA method was used for statistical analysis and p<0.05 was considered significant. Results: CO increased significantly after fluid challenge when compared to baseline (from 3.48±1.14 to 4.34±1.43 L/min, p<0.001). MAP increased significantly after fluid administration when compared to baseline (80±19 to 86±17, p=0.002). RRI did not significantly differ from baseline after fluid challenge (62±9 to 60±10, p=0.11). There was a negative correlation between RRI and MAP at baseline and after fluid challenge. Conclusion: The effect of hemodynamic changes on renal perfusion after fluid challenge is controversial. In our study, 500 mL of crystalloid treatment for 30 minutes increased MAP and CO, but did not contribute to the improvement of RRI in patients who were fluid responsive. We found that fluid challenge did not improve RRI in the early phase of the fluid resuscitation in fluid responsive critically ill patients and RRI is unsusceptible to systemic hemodynamic changes during this period.
SMOKING AWARENESS IN COPD PATIENTS

A B S TR A C T Aim of the study is to analyze the level of awareness in COPD patients and analyzing the need for awareness in target groups. Methodology: 44 COPD patients diagnosed as per GOLD criteria were selected for the study and a cross sec-tional study was done and data obtained using a questionnaire method was evaluated using proper statistical analysis. Results: Majority of the patients belongs to age group between 65 and 74 years and majority belongs to very low eco-nomic status. Only 50% of patients were having awareness regarding COPD and smoking correlation. 47.7 % patients were heavy smokers. 95.5% patients who got awareness about the disease quit smoking. Government hospital patients were more aware than private hospital patients regarding COPD. Conclusion: COPD awareness can really make an impact on the epidemiology and prognoses in COPD patient’s . Government programmes are really useful in creating awareness among patients to quit smoking. Lower socio economic patients should be a prime targets in awareness pro-grammes.
Late Gadolinium Enhancement Predicts Improvement in Systolic Function after Aortic Valve Replacement in Patients with Severe Aortic Stenosis

BACKGROUND Myocardial fibrosis, as detected by late gadolinium enhancement (LGE) magnetic resonance imaging (MRI), is related to mortality after aortic valve replacement (AVR) in patients with severe aortic stenosis (AS). However, whether LGE predicts improvement in LV systolic function after AVR remains unclear. OBJECTIVES This study aimed to determine whether myocardial fibrosis quantified by LGE MRI predicts improvement in left ventricular (LV) systolic function after AVR in patients with severe AS. METHODS Twenty-nine patients with severe AS who were scheduled to undergo AVR were enrolled in this study. Two-dimensional echocardiography and contrast-enhanced MRI were performed before AVR. Global longitudinal strain (GLS) as an index of LV systolic function and LGEcore (g: > 5 SD of normal area), LGEgray (g: 2 SD-5 SD), and LGEcore+gray (g) were measured. The fibrosis index (FI, %) was assessed using intraoperative LV myocardial specimens obtained from 13 patients. One year after AVR, changes in GLS were examined by echocardiography to assess improvement in LV function. RESULTS
Commentaar Effects of Short-Term Experimental Insulin Resistance and Family History of Diabetes on Pancreatic β-Cell Function in Nondiabetic Individuals

Commentaar op Neda Rasouli, Terri Hale, Steven E. Kahn, Horace J. Spencer, Steven C. Elbein, Effects of Short-Term Experimental Insulin Resistance and Family History of Diabetes on Pancreatic β-Cell Function in Nondiabetic Individuals, The Journal of Clinical Endocrinology & Metabolism, Volume 90, Issue 10, 1 October 2005, Pages 5825–5833, https://doi.org/10.1210/jc.2005-0048