Miracle-dz/UniFAR-FTUs huggingface dataset:
Solid force on normal tissue Cancer cell Collagen Stromal cell Hyaluronan Endothelial cell High blood flow Blood stasis

Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, they can increase cells’ invasive and metastatic potential. Tumor vessels— while nourishing the tumor—are usually leaky and tortuous, which further decreases perfusion. Hypoperfusion and hypoxia contribute to immune evasion, promote malignant progression and metastasis, and reduce the efficacy of a number of therapies, including radiation. In parallel, vessel leakiness together with vessel compression causes a uniformly elevated interstitial fluid pressure that hinders delivery of blood-borne therapeutic agents, lowering the efficacy of chemoand nanotherapies. In addition, shear stresses exerted by flowing blood and interstitial fluid modulate the behavior of cancer and a variety of host cells. Taming these physical forces can improve therapeutic outcomes in many cancers. 321 A nn u. R ev . B io m ed . E ng . 2 01 4. 16 :3 21 -3 46 . D ow nl oa de d fr om w w w . a nn ua lr ev ie w s. or g by U ni ve rs ity o f B er n on 0 8/ 14 /1 4. F or p er so na l u se o nl y. BE16CH13-Jain ARI 28 May 2014 12:51
Smallholder farmers access to improved groundnut production and value addition technologies in Eastern Uganda

Groundnuts are a key crop in Uganda, both as a source of nutrition and income. However, lack of knowledge and information on progressive practices along the groundnut value chain is a key contributor to the poor performance of the sub-sector. This study envisages establishing baseline knowledge on key aspects of groundnut production, processing and marketing with a view to identifying areas and gaps for capacity building interventions. A total of 155 farmers were randomly selected and primary data collected in early 2013 from three districts in Eastern Uganda namely; Bukedea, Mbale and Tororo. Results indicate that farmers were aware of most recommended pre and post harvest technologies/ practices including knowledge on improved groundnut varieties, superior agronomic practices, proper drying and cleaning, long-life storage, grading, sorting and packaging. However, even though most farmers had knowledge of the progressive technologies; quite a substantial number of them did not use these technologies in groundnut production and value addition. This finding points to presence of constraining factors that may hinder access and application of known technologies. Therefore, capacity building efforts to increase both access and utilization of value-enhancing groundnut technologies will eliminate the gap between awareness and use of these technologies for improved livelihoods. Key words: Awareness, groundnut, knowledge, technology utilization, Uganda.
2 DUPUYTREN DISEASE DIAGNOSIS AND OBESITY Although Dupuytren disease

Purpose Dupuytren disease is a common benign fibroproliferative disorder causing thickening and shortening of the palmar fascia of the hand. The exact etiology of the disease is unclear but known risk factors such as increased age, male sex, and northern European ethnicity have been established. A link between body mass index (BMI) and Dupuytren disease has not been established previously. The purpose of this study was to test the hypothesis that lower BMI is associated with increased risk for Dupuytren disease diagnosis.
Recurrent radio emission and gas supply : The radio galaxy B2 0258+35

Outlined is the discovery of a very faint, diffuse, low surface-brightness (0.5 mJy beam(-1), 1.4 mJy arcmin(-2) on average) structure around the radio source B2 0258+35 hosted by an HI-rich early-type galaxy (NGC 1167). Because B2 0258+35 is a young compact steep spectrum (CSS) source, the newly discovered structure could represent a remnant from an earlier stage of activity of an active galactic nucleus (AGN). We explain in detail all possibilities for triggering the radio activity in B2 0258+35 regarding gas accretion in a recurrent AGN activity framework. NGC 1167 hosts a very regular, extended and massive HI disk that has been studied in great detail. It has regular kinematics on large scales, which, together with stellar population studies of NGC 1167, exclude the possibility of a recent merger as the trigger for the current AGN activity that is responsible for the CSS source. Previous studies of the HI closer to the core seem to preclude the assumption of a circum-nuclear disk of HI as the source of the accreting gas. We consider the cooling of gas from the hot X-ray halo as a possible alternative option for the fueling of the AGN, as suggested for other sources of similar radio power as B2 0258+35. This would provide a more likely explanation for the recurrent activity. Furthermore, if the previously made suggestion in the literature that the inner CSS may not be able to grow to large scales is correct, this implies that different cycles of activity may have different characteristics (e. g. radio power of the emission). Estimates are given for the age of the faint diffuse emission as well as for the current accretion rate, which agree well with literature values. If our assumptions about the accretion mechanism are correct, similar large-scale, relic-like structures should be more commonly found around early-type galaxies, which will hopefully be confirmed by the next generation of sensitive, low-frequency radio surveys.
Validated Survey Instrument Analysis of Satisfaction and Well-Being in the Short Follow-up From Breast Augmentation Using the

Background: Improvements in satisfaction and quality of life following breast augmentation have been shown in the literature. However, few studies have used validated survey instruments. The BREAST-Q is a strong and validated questionnaire for breast augmentation. Objective: The authors implement the BREAST-Q to analyze patient-reported satisfaction and quality of life following breast augmentation. Methods: In this prospective study, all patients who underwent breast augmentation with a single surgeon (AT) between January 2008 and May 2009 were asked to fill out BREAST-Q surveys anonymously during the preoperative and 6-week postoperative periods. Statistical analysis was performed and a P value of <. 05 was considered significant. Results: Of the 155 patients who underwent breast augmentation during the study time period, 59 (38%) completed the preoperative survey and 70 (45%) completed the postoperative survey. Significant improvements were seen for satisfaction with breast appearance (P < .001), psychosocial wellbeing (P < .001), and sexual well-being (P < .01) between preand postoperative surveys. Conversely, a significant decrease was seen in the physical well-being category (P < .001). Satisfaction with overall outcomes most strongly correlated to satisfaction with appearance of breasts (r = 0.8) and less strongly with psychosocial well-being and sexual well-being (r = 0.6). No correlation was found between satisfaction with overall outcomes and physical well-being (r = 0.0). Conclusions: As the implementation of evidence-based medicine continues to grow in everyday practice, there is increasing pressure to use validated survey instruments to demonstrate patient-reported outcomes. In this study, the authors have shown that breast augmentation significantly improves satisfaction with breast appearance, psychosocial well-being, and sexual well-being and that overall satisfaction is most strongly correlated with breast appearance satisfaction.
Calcium, boron and vegetal regulators in the fruit fixing in tomato

Tomato crop presents expressive area of cultivation and economical importance for the agribusiness for the state of Sao Paulo. It was evaluated the influence of boron and calcium nutrients and plant growth regulators to increase fruit set in tomato, in view of the inadequate supply of nutrients, coupled with other external factors may promote the abortion of flowers and fruits. To evaluate the treatments, it was quantified the rate of fruit set in tomato ‘Saladinha Plus’, and it was ranked the fruit concerning marketing and mass (kg), indicating that due to good conditions in which the experiment was conducted, the treatment application, even in protected cultivation, did not provide greater fruit set, and no increase in the number of marketable fruits.
The Current Models of Credit Portfolio Management: A Comparative Theoretical Analysis

The present paper aimed at studying the current models of credit portfolio management. There are currently three types of models which consider the risk of credit portfolio: the structural models (Moody's KMV model, and Credit- Metrics model), the intensity models (the actuarial models) and the econometric models (the Macro-factors model). The development of these three types of models is based on a theoretical basis developed by several researchers. The evolution of their default frequencies and the size of the loan portfolio are expressed as functions of macroeconomic and microeconomic conditions as well as unobservable credit risk factors, which would be explained by other factors. The present study developed three sections to explain the different characteristics of those three models. The purpose of all the models is to express the default probability of credit portfolio.
tlight on vision velopment of retinal layers ́ veloppement de la stratification rétinienne

A noticeable characteristic of nervous systems is the arrangement of synapses into distinct layers. Such laminae are fundamental for the spatial organisation of synaptic connections transmitting different kinds of information. A major example of this is the inner plexiform layer (IPL) of the vertebrate retina, which is subdivided into at least ten sublayers. Another noticeable characteristic of these retina layers is that neurons are displayed in the horizontal plane in a non-random array termed as mosaic patterning. Recent studies of vertebrate and invertebrate systems have identified molecules that mediate these interactions. Here, we review the last mechanisms and molecules mediating retinal
Textile Materials in Liquid Filtration Practices: Current Status and Perspectives in Water and Wastewater Treatment

Filtration is considered the keystone of water and wastewater treatment and is used for various purposes, such as sludge dewatering and concentrating any solution. Moreover, as an advanced filtration technology, membranes can remove materials ranging from large visible particles to molecular and ionic chemical species. Proper selection of filter media/membrane material in filtration processes is often the most important consideration for assuring effi - cient separation. Filter media can be classified by their materials of construction, such as cotton, wool, linen, glass fiber, porous carbon, metals, and rayons. Recently, new polymeric materials have been used both individually and/or blended in filtration processes for the treatment of waters and wastewaters. The purpose of this chapter is to bring an overview on the textile-originated filter materials in filtration applications from conventional filtration to advanced membrane processes. Although many researches on filter media are available, very few researches have been carried out on the cutting-edge technologies about using filter materials on filtration processes from classical to advanced membrane processes. Therefore, in this part of the book, following major and minor titles are stated truly on the aforemen - tioned new technologies and linked with conventional methods in water and wastewater treatment applications.
Heterogeneity, Asymmetries and Learning in InfIation Expectation Formation: An Empirical Assessment

Relying on Michigan Survey' monthly micro data on inflation expectations we try to determine the main features -- in terms of sources and degree of heterogeneity - of inflation expectation formation over different phases of the business cycle and for different demographic subgroups. We identify three regions of the overall distribution corresponding to different expectation formation processes, which display a heterogeneous response to main macroeconomic indicators: a static or highly autoregressive (LHS) group, a "nearly" rational group (middle), and a group of "pessimistic" agents (RHS), who overreact to macroeconomic fluctuations. Different learning rules have been applied to the data, in order to test whether agents' are learning and whether their expectations are converging towards rational expectations (perfect foresight). The results obtained by applying conventional and recursive methods confirm our initial conjecture that behaviour of agents in the RHS of distribution is more associated with learning dynamics. We also regard the overall distribution as a mixture of normal distributions. This strategy allows us to get a deeper understanding of the existence and the main features of convergence and learning in the data, as well as to identify the demographic participation in each subcomponent
Coniveau filtration and mixed motives

We introduce the motivic coniveau exact couple of a smooth scheme, in the framework of mixed motives, whose property is to universally give rise to coniveau spectral sequences through realizations. The main result is a computation of its differentials in terms of residues and transfers of mixed motives, with a formula analog to the one defining the Weil divisor of a rational function. We then show how to recover and extend classical results of Bloch and Ogus for motivic realizations.
Drosophila melanogaster A core transcriptional network for early mesoderm development in data

data Supplementary http://www.genesdev. org/cgi/content/full/21/4/436/DC1 "Supplemental Research Data" References http://www.genesdev. org/cgi/content/full/21/4/436#References This article cites 69 articles, 42 of which can be accessed free at: service Email alerting click here top right corner of the article or Receive free email alerts when new articles cite this article sign up in the box at the
Name of the Pro gradu thesis: ANALYSIS OF JAPANESE AND FINNISH FURNITURE DESIGN: A consideration for product identity and the relativity of industrial development and cultural context Writer:

In a globalized product design market, firms take national identity into consideration to survive among the competitors, because a particular identifying feature can be the decision making factor for customers to buy a particular product. In such a situation, you may realize something as “Japanese-like” or “Finnish-like” in designs as you hold the product in your hand. But why do you think like that? The aim of this study is to clarify the factors that characterize these ideas, in terms of furniture design, with a focus on industrial development and the cultural contexts of Japan and Finland. The study is twofold, with a theoretical framework and an empirical framework. The theoretical analysis works with cultural industrial context and also argues that the transition of industrial development significantly affects national product design orientation and helps characterize products. The empirical analysis works with questionnaires concerning product image. The results conceptualize cultural references in both Japanese and Finnish furniture design. However, the results also present the realistic difficulty of recognizing products. The paper concludes by arguing that factors affecting customer’s decision making are also influenced by not only product design but the socio-culture they belong to. Therefore, measuring product image is not the only way to define national product identity, and the image is formed by both customers and product design factors.
An perc tech of c

Material and methods. Three independent examiners provided blind testing for the study. Examiner 1 transilluminated 30 extracted teeth and 23 three-dimensional copy replica control teeth and documented any visible cracks. Each tooth was then mounted in acrylic resin with a periodontal ligament substitute. Examiner 2 examined each specimen aided by the clinical microscope and transillumination and documented visible tooth cracks and fractures. Examiners 1 and 3 then independently tested all specimens with a device developed for quantitative percussion diagnostics. All visible cracks/fractures were removed with a water-cooled fine diamond rotary instrument. Crack visibility was enhanced by the use of a clinical microscope, dye penetrant, and accessory transillumination. This disassembly process was video documented/photographed for each specimen. One more quantitative percussion diagnostics testing was administered when the disassembly was complete.
Prostate cancer cells home to bone using a novel in vivo model : modulation by the integrin antagonist GLPG 0187 Running title : new in vivo model for tracking early prostate cancer homing to bone

Urology Research Laboratory 3 , Department of Urology, University of Bern, Murtenstrasse 35, CH3010, Bern, Switzerland Department of Urology 4 , Leiden University Medical Center, J3-100, P.O. Box 9600, 2300 RC Leiden, The Netherlands. Urology & Oncology 5 , Nuffield Department of Surgery, John Radcliffe Hospital University of Oxford, Oxford, OX3 9DU, UK Galapagos SASU 6 , 60, Avenue Gaston Roussel, 93230 Romainville, France
Knowledge engineering is split into knowledge acquisition and system implementation , and a review provides examples of knowledge elicitation and machine induction in industrial domains

Al~tt~et--The inherent difficulties involved in the process of extracting knowledge from experts are discussed and identified. Such difficulties have resulted in few expert systems progressing beyond the prototyping stage. The conflicting terminology used to describe the whole process is examined and, as a result, knowledge engineering is defined as the appropriate term for the whole process. This is then further split into knowledge acquisition and system implementation. Finally, knowledge acquisition is further subdivided into knowledge elicitation and machine induction. The particular problems associated with the construction of expert systems in industrial control applications are discussed. Such systems are characterised by the nature of their user population, the type of support provided and whether they operate on-line or off-line. The importance of defining functionality and goals at the outset is stressed. The need for user models is also highlighted. The various techniques used in knowledge elicitation--interviews, questionnaires, observations, protocol analyses, teachback interviewing, walkthroughs and formal techniques--are briefly reviewed. The alternative approach using machine induction techniques is also discussed. An examination is made of the competing approaches involving bottom-up and top-down techniques. The benefits resulting from the application of cognitive task analyses rather than technologydriven approaches are also stressed. Current knowledge acquisition tools such as KRITON, KADS, ACQUIST, KEATS and ROGET are reviewed. Examples are given of the use of time-line techniques in power plant knowledge acquisition, knowledge and task analyses in the construction of a failure management expert system and of the use of inductive techniques in gas-oil separator design and satellite power systems control. In the latter case, the use of qualitative modelling is highlighted.
Human Liver Cancer Glypican 3 Antibody as a Potential Antitumor Agent for − Anti

Human glypican 3 (GPC3) is preferentially expressed in the tumor tissues of liver cancer patients. In this study, we obtained a monoclonal antibody (mAb) against the COOHterminal part of GPC3, which induced antibody-dependent cellular cytotoxicity (ADCC). The mAb, designated GC33, exhibited marked tumor growth inhibition of s.c. transplanted Hep G2 and HuH-7 xenografts that expressed GPC3 but did not inhibit growth of the SK-HEP-1 that was negative for GPC3. GC33 was efficacious even in an orthotopic model; it markedly reduced the blood A-fetoprotein levels of mice intrahepatically transplanted with Hep G2 cells. Humanized GC33 (hGC33) was as efficacious as GC33 against the Hep G2 xenograft, but hGC33 lacking carbohydrate moieties caused neither ADCC nor tumor growth inhibition. Depletion of CD56 cells from human peripheral blood mononuclear cells markedly abrogated the ADCC caused by hGC33. The results show that the antitumor activity of hGC33 is mainly attributable to ADCC, and in human, natural killer cell– mediated ADCC is one possible mechanism of the antitumor effects by GC33. hGC33 will provide a novel treatment option for liver cancer patients with GPC3-positive tumors. [Cancer Res 2008;68(23):9832–8]
Too Big to Fail Perception by Depositors: an empirical investigation

We examine a run from smaller to the largest banks in Brazil during the international financial turmoil in late 2008. Since Brazilian banks had no exposure to subprime securitized loans, the run is an opportunity to observe depositor reaction to a shock that is exogenous to the domestic banking system. Our empirical strategy allows us to disentangle the too big to fail benefit from the other features continuously related to size. Our unique database allows us to observe the behavior of uninsured deposits and of different types of holders of certificates of deposits, such as individuals, institutional investors and non-financial corporations. Taken together, our results are consistent with the idea that depositors ran from the smaller banks to the largest banks because they believed the largest banks were too big to fail. We also find that institutional investors had an important role in inducing the behavior of other depositors during the crisis: banks that had relatively more deposits of institutional investors ex-ante suffered more deposit outflows throughout the crisis.
ATGAAAACCGAAAAACGTTACCTGGTTCCGGGTGACTACA TGGCTGACCCGGCTGTTCACGTTTTCGACGGTAAACTGTACATCT ACCCGTCTCACGACTGGGAATCTGGTATCGCTGAAAACGACAACG GTGACCACTTCAACATGAAAGACTACCACGTTTACTCTATGGACG ACGTTATGAACGGTGAAATCAAAGACCACGGTGTTGTTCTGTCTA CCGAAGACATCCCGTGGGCTGGTCGTCAGCTGTGGGACTGCGACG TTGTCTGCAAAGACGGGAAATACTACATG

Divalent metal-activated glycoside hydrolase family 43 (GH43) β-xylosidases have been found to have high kcat/Km for xylooligosaccharides and may demonstrate high efficacy in industrial reactors digesting hemicellulose. By searching an amino acid database, we found a Bacteroides ovatus GH43 β-xylosidase termed BoXA that is 81% identical in overall amino acid sequence to a GH43, divalent metal-activated β-xylosidase with high kcat/Km, and also it has 19 of 20 residues in the active site conserved. However, unlike its metal-activated homolog, the B. ovatus enzyme does not lose activity after extensive EDTA treatment nor does it gain activity by addition of divalent metal ions. Thus, either it cannot be activated by divalent metal or it maintains a tightly bound, non-exchangeable metal ion. At 25 °C and pH 6.0, the kcat is 69 s −1 for xylobiose and kcat/Km is 210 s −1 mM for xylotriose, with the latter being 0.7 that of the highest known value. The determined Ki for D-glucose is 4.9 M, which is the highest known for a β-xylosidase. The enzyme has potential utility operating in bioreactors digesting plant biomass.
chronic myeloid leukemia + BCR-ABL 1 JAK of all trades : JAK 2-STAT 5 as novel therapeutic targets in

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