Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of metallo-β-lactamase and extended-spectrum β-lactamases producing Escherichia coli isolates from urinary tract infections in southeast of Iran

BackgroundUrinary tract infection (UTI) is one of the most commonly encountered diseases in clinical settings and uropathogenic Escherichia coli (UPEC) is the major causative pathogen of UTI. The increase of antibiotic resistance among isolates of E. coli has become a main concern worldwide. The purposes of this study were to determine the phylogenetic background, prevalence and characterize of extended-spectrum β-lactamases and metallo-β-Lactamase produced by E. coli from UTIs.Materials and MethodsTwo hundred and sixteen E. coli isolates were isolated from UTI. The isolates were screened to determine the phylogenetic background and prevalence of CTX-M-15, PER, VEB, IMP and VIM genes by PCR. The antimicrobial susceptibility of isolates was determined by disk diffusion and broth micro-dilution methods. The isolates were screened using a double-disc synergy test.ResultsPhylotyping of isolates revealed that isolates segregated in phylo-groups A (40.74%), B1 (7.87%), B2 (18.05%) and D (33.34%). By disk diffusion test 61.57% of isolates were resistant to cefotaxime, 35.64% to ceftazidime, 26.38% to aztreonam, 16.66% to cefepime and 6.48% to imipenem. Among the studied ESBL isolates, 72.41% isolates were positive for the CTX-M-15 gene. None of the isolates were positive for IMP, VIM, PER and VEB genes.ConclusionThe ESBL-producing strains were associated with shifts in phylogenetic distribution toward none-B2 phylo-groups and they mainly belonged to A and D groups.
Concurrent Small-Cell Transformation and Emergence of Trans-C797S and T790M Mutations Under Sequential Treatment With EGFR Inhibitors in Lung Adenocarcinoma.

Epidermal growth factor receptor (EGFR) gene mutations are strong oncogenic drivers in a subset of non–small-cell lung cancer (NSCLC). Their inhibition with specific tyrosine kinase inhibitors (TKIs) represents a successful example of precision medicine. Nevertheless, disease progression almost invariably occurs after 9-14 months of treatment with either gefitinib, erlotinib, or afatinib (firstand second-generation TKIs) and after 19 months with osimertinib (a thirdgeneration TKI) because of the development of acquired therapeutic resistance.
Brand Awareness and Quality Product on Purchase Decision Mediating Consumer Perception: Case Study in PT. Tugu Pratama Indonesia

This study aimed to analyze the influence of brand awareness and product quality on purchasing decisions through consumer perception. The research was conducted at PT Tugu Pratama Indonesia by the number of samples are 119 people in the area of the organization. Sampling using a saturated sample. Analysis of data using path analysis. The results showed that influence brand awareness and product quality on purchasing decisions by consumers' perceptions of positive and significant influence.
Current State of Bedside Glucose Meter Testing.

As arguably the most measured analyte in clinical chemistry, glucose remains a topic of great discussion. The measurement of glucose is relatively straightforward and robust in the central laboratories, whereby glucose in plasma or serum and other body fluids is quantified using enzymatic-spectrophotemetric–based methods. At the bedside, glucose is most routinely assessed with handheld meters using test strips that measure whole blood glucose in an enzymatic-electrochemical manner. Test strip methods have come a long way since the early days; current generation glucose meters provide rapid measurement (<10 seconds) of glucose, in small volumes of whole blood (<10 μL), using a variety of specimen types (arterial, venous, capillary, and neonatal heel-stick whole blood). The operation of the device is purposefully designed to be intuitive and simple. Meter features such as operator management, wireless connectivity to the laboratory/hospital information system, and QC testing features are all important quality assurance parameters characteristic of today's hospital glucose meters. Historically, glucose meter testing did not start in the hospital; it started in physicians' offices around 1970 with the Ames Reflectance Meter. Over time, the glucose meter evolved in both design and technology, finding its way into the hands of patients, quickly becoming a very useful tool for the self-management of diabetes. Eventually, these glucose meters migrated into …
Characterization of a precision modular sinewave generator

At the Czech Metrology Institute (CMI) we have developed a precision modular sinewave generator for impedance ratio bridges. The generator was developed to improve previously available designs regarding amplitude and phase accuracy, linearity, absolute stability, stability of the ratio between two outputs and harmonic distortion. It generates up to 7 Vrms in a frequency range from 1 mHz up to 20 kHz, extendable to 100 kHz with small changes to the filters. The amplitude resolution is better than 0.01 μV V−1 of full scale with an output voltage stability of 0.05 μV V−1/30 min and a stability for the ratio between two outputs of 0.02 × 10−6 over several hours. The generator can be powered from internal batteries and is controlled via optically isolated connections. The internal clock and voltage references can be replaced by external ones, optically coupled in the case of the clock. In this paper, we discuss experimental results obtained with the generator used as a signal source in digital impedance bridges with relative combined uncertainties from 10–5 down to 10–8. The generators have been used in a bridge to drive a quantum Hall resistor in the AC regime. The use of a generator with an AC quantum voltmeter will also be discussed. The generator is not only applicable in the field of AC impedance metrology but also for on-site comparisons of AC quantum voltage standards or, in general, where there is a need for precision voltage sources.
Adopting knowledge building pedagogy to support epistemic agency and collaborative contribution in science classes: A case study in New Zealand schools

The aim of a knowledge building community (KBC) is to produce new ideas and knowledge, which is useful to, and useable by the community (Scardamalia, 2002). Knowledge building has been described as a community process where students are empowered in knowledge creation as legitimate contributors (Lai, 2014). This phase of idea creation and improvement is at the heart of the knowledge building pedagogy.
Quantifying the spatial distribution and trends of supplementary feeding sites in South Africa and their potential contribution to vulture energetic requirements

Old world vultures are the most threatened group of raptors globally. Supplementary feeding sites (SFS) are a popular conservation tool, widely used to assist vulture populations. Despite their popularity, the impact of SFS on vultures remains largely unstudied. A lack of knowledge on the number, distribution and management of SFS is a key factor hindering such research. In this study, we compile records of SFS in South Africa and conduct questionnaires with SFS managers to characterize SFS. We identify 143 currently active SFS. Our data suggest that SFS numbers have been stable over the last decade. The average provisioning rate for all SFS was 64.6 kg day−1. Overall SFS provide an estimated 3301 tonnes of food to scavengers each year, the equivalent of 83% of the energetic needs of all vultures in the region. This contribution was highly skewed, however, with just 17% of active SFS sites providing 69% of all food. Furthermore, these resources were not equally distributed, with SFS in Limpopo, North West and Kwazulu‐Natal provinces providing 83% of the total meat provisioned. The three most common meat types provided at SFS were beef (39%), pork (33%) and game (19%). Worryingly, we found that 68% and 28% of SFS managers were unaware of the potential harmful effects of lead and veterinary drugs, respectively, which highlights potential poisoning risks associated with SFS. Examining exposure to SFS by different vulture species, we found that whilst SFS are accessible across the distribution range of vultures with large home ranges (e.g. African white‐backed and Cape vultures), those species with smaller home ranges have relatively poor accessibility. With this study, we demonstrate the potential importance, but also associated risks, of SFS to vultures in South Africa, and provide the information base to assess the impacts of this popular but as yet largely unassessed conservation tool.
External financial flows and institutional building: the impact of remittances on civil liberties in aid dependent countries

ABSTRACT We analyse the impact of both official development assistance and migrant transfers on civil liberties in developing countries, using a sample of 63 countries over the period 1984–2004. We found that while both larger migrant transfers and larger inflows of aid are associated with stronger civil liberties, workers remittances have a higher impact than aid with no interdependency between the two.
THE IMPACT OF CONTINUOUS TRAINING ON ORGANIZATIONAL INVOLMEMENT IN THE MOROCCAN CONTEXT

This article focuses on the study of the link between human resources management (HRM) practices related to continuous training and the three-dimensional organizational involvement of employees of private companies in Morocco. The research results show, on the one hand, that continuous training is a lever of affective organizational involvement and, on the other hand, an absence of correlation with normative involvement and calculated involvement.
Student and faculty perspectives on Laboratory Based Learning (LBL) sessions in Physiology

Objective: To explore students’ and faculty members’ perspectives regarding LBL sessions-the gaps/pitfalls- to explore possi bilities for improvement. Method: Two sets of questionnaires, one each for students and faculty members were developed and administered to the students of first year MBBS (n=113) and Faculty members of physiology department (n=13) of MMMC, Manipal. Both questionnaires had closed-ended questions (no negative statements) inviting responses in the form of Like rt scale. Open-ended questions were included in the questionnaire distributed to fa culty members. Quantitative analysis was done using SPSS version 16. Results: Students agreed to all item s, with a median score of 4. Students’ responses clearly indicated that, in general, they were satisfied with conduction of LBL sessions in physiology, while, faculty members concurred with them with a median score of 4 for items other than student related and expressed that current LBL sessions were adequate for MBBS curriculum. Faculty members were of the opinion that students need to practice more in LBL sessions. They also suggested inclusion of additional teaching aids in LBL sessions. Conclusion: Majority of students and faculty members were satisfied with the content and methodology employed in the current laboratory based sessions in physiology. Some of the suggestions given by students and faculty members could be easily implemented for improving the process, while others require additional infrastructure and logistic support.
Um Modelo de Avaliação do Pensamento Computacional na Educação Básica através da Análise de Código de Linguagem de Programação Visual

Teaching computational thinking in K-12 is important to prepare students for the challenges of the 21st century. Consequently, there is a need to assess the acquired competences. In this context we present a model for the assessment of computational thinking competences related to algorithm and programming with visual programming languages. The model was systematically developed based on reference curricula and instantiated and automated for projects created with App Inventor. Results from a large-scale evaluation, with more than 88,000 mobile applications created with App Inventor, indicate good reliability and demonstrate the model’s validity. Resumo. O ensino do pensamento computacional na Educação Básica, é importante para preparar os alunos para os desafios do século XXI. Desta forma, surge a necessidade de avaliação das competências adquiridas. O presente trabalho apresenta um modelo de avaliação de conceitos de algoritmos e programação, como parte do pensamento computacional, com linguagens de programação visual. O modelo foi sistematicamente desenvolvido com base em currículos de referência e foi instanciado e automatizado para projetos criados com App Inventor. Resultados de uma avaliação em larga escala, com mais de 88 mil aplicativos criados com App Inventor, indicam boa confiabilidade e demonstram a validade do modelo.
Gaming Insight: Conversion of Popular Sedentary Games into Motion-Based Form

ABSTRACT Motion-based gaming can aptly substitute an individual’s daily exercise requirements while being a great source of entertainment. Conversion of sedentary-based games into motion-based form can reach more gamers who are otherwise avoiding daily exercises. Toward that end, there is scope for research on the factors to be considered to retain a greater number of players by recreating the games they are already accustomed to playing. Hence, we developed the motion-based forms of two popular sedentary games, Flappy Bird, and Temple Run. We then conducted a study incorporating both of the games with a group of participants. By analyzing the user experience through feedback and observation, we determined the key factors involved in converting conventional games into motion-based form. Our study shows that if specific considerations are made, motion-based forms of sedentary games have the potential to be more or similarly appealing and can achieve greater retention when compared to their sedentary counterpart.
Stories In The Time Of Cholera Race And Public Health In Venezuela

n 1992 and 1993 some five hundred people died in the maze of rivers and thousands of large and small islands that form the delta region of the Orinoco River in eastern Venezuela. The disease that killed so many so quickly was cholera. One of us, Charles, stumbled onto the epidemic in November 1992 during a two-week visit to Tucupita, a city of some 40 thousand inhabitants and the capital of Delta Amacuro state. Clara was working for the regional office of the Ministry of Health and Public Assistance, and she helped to coordinate efforts to prevent the spread of the epidemic. Many friends from the delta were living on the streets of Tucupita and nearby Barrancas del Orinoco, another small city on the edge of the delta, begging and performing odd jobs to survive, sleeping in shelters con-
An enhanced mobile ambulatory assessment system for alcohol craving studies

Currently, most methods in clinical psychology research primarily rely on questionnaires and interviews with examiners instead of providing real-life subject behavioral and psychology data monitoring and collecting services. This thesis presents an android-OS-based mobile Ambulatory Assessment System, for psychology research -especially alcohol craving studies – to improve current methods and provide real-time data monitoring, collecting and processing. As current generation smartphones provide more powerful communication platform, embedded with robust built-in sensor suits and vigorous processing and storage capabilities, smartphones play an increasingly significant role in various sensing tasks such as activities monitoring personal health surveillance and environment. This system consists of four parts: a wearable sensor (Equivital EQ2 sensor) that measures physiological data, an Android smartphone, a web server and a data analysis module. The smartphone is responsible for collecting and recording physiological data from the wireless wearable sensor, interacting with the users to conduct various surveys, and uploading data to the web server. The server is responsible for data processing, computation, and visualization. Utilizing machine learning methods, data from the sensor and survey build models that predict how various psychological disorders cause alcohol or other substance cravings and emotion dysregulation. The system has been deployed in a field study of alcohol craving, and initial data collected from real subjects proved promising.
A Rare Association of Rheumatoid Arthritis with Crohn’s Disease

Crohn’s disease (CD) is an chronic autoimmune inflammatory bowel disease (IBD) which may involve any part of the gastrointestinal system (GIS) (1). Although the rellationships among autoimmune diseases are known, association of rheumatoid arthritis (RA) and CD is an extremely rare condition (2,3). A 50-year-old male patient who had the diagnosis of seropositive RA for 5 years, presented with the complaints of bloody diarrhea and abdominal pain. The RA treatment had been regulated as a combination of methotrexate, sulfasalazine and hydroxychloroquine, and the patient reported that he was regularly taking the medical therapy. In joint examination, metacarpophalangeal joint arthritis were found bilateral. No hand deformity was observed. In physical examination, there were no findings except tenderness in the lower abdominal quadrants. There was not any bacterial growth in the stool culture. The results of the colonoscopy, found inflammation in the ileum (Figure 1a, 1b). Histopathologic examination was compatible with CD. Anteroposterior hand radiography revealed narrowing in 3rd and 4th proximal interphalengeal joints (Figure 1c). Genu varum deformity was found in the knee and magnetic resonance imaging (MRI) revealed synovial hypertrophy. Biochemical analysis yielded sedimentation rate as 22 mm/h (Reference range: 0-20 mm/h), C-reactive protein 1.21 mg/dL (reference range: 0-0.5 mg/dL), rheumatoid factor (+) and anti cyclic citrullinated peptide (CCP) (+). Mesalazine and azathioprine were added to his treatment protocol. At follow-up, complaints of the patiens gradually regressed within 4 months. Articular system involvement is commonly seen in IBD such as ulcerative colitis (UC) and CD. Axial and peripheral articular findings may commence before, concurrently or after the diagnosis of IBD. Peripheral arthritis is generally in form the oligoarticular involvement of the large joints. However, in a small portion of IBDs, an arthritis form may be seen, resembling rheumatoid arthritis and often affecting the small joints of the hand symmetrically and polyarticularly (4). Peripheral arthritis is reported in CD by 10-20% which is more frequent compared to UC (5). Our patient was diagnosed with CD, suggesting us the joint findings may be occured due to this condition. However, IBD arthritis is seronegative and never or rarely causes joint destruction compared to RA (5). In our patient, arthritis had begun about 5 years before GIS symptoms. According to 2010 American College of Rheumatology/European League Against Rheumatism criteria, positivity of anti CCP, RF antibodies, marked synovial hypertrophy in the knees on MRI and narrowing of the joint spacing found in our patient confirmed the diagnosis of RA. Our patient who could not describe an association between the exacerbation of CD and arthritis gave positive response to RA treatment. Hatice Resorlu, Erdem Akbal*, Ferhat Gokmen, Yilmaz Savas
A fuzzy-based roadmapping model for enhancing high-tech small firms’ technological entrepreneurship capabilities: cases of Iran

ABSTRACT Technology-based firms need to survive via technological changes. Technological entrepreneurship is concentrated on identifying and exploiting the tech-opportunities for creating product innovation. This paper introduces a fuzzy-based tool to promote innovation throughout firms in order to enhance technological entrepreneurship capabilities (TEC). The effort involves identifying components of TEC to develop the inference system, specifying the fuzzy relationship among these components, assessing the TEC in firms, and designing a TEC roadmap after a fuzzy-based gap analysis. Designed roadmaps introduce technological change priorities as a growth path to firms to move up along the ladder of competitiveness. Based on the results, a method for categorizing firms into four distinct levels that involve passive, reactive, proactive and innovative is introduced. Hence, firms have an action plan to enhance TEC from passive to innovative level in a time-based transition pathway.
Prevalence of Staphylococcus in raw meat samples in Southern Assam, India

The objective of the study is to find the prevalence of staphylococcus from raw meat samples in Southern Assam. In the present study 65 raw meat samples (chicken and goat) were collected from various regions in and around Southern Assam. Out of 65 samples analyzed 30 samples 17 from chicken and 13 from goat were positive for Staphylococci with the prevalence rate of 48.57% from Chicken and 43.33% from goat. Staphylococcal isolates were found variably resistant to the antibiotics tested. 80% of the isolates were positive for at least one of the antibiotics used in this study. The isolates showed maximum resistance for penicillin (73.33%) which is followed by Erythromycin(36.66%) Tetracyclin(26.66%) Oxacillin(23.33%) Ciprofloxacin (16.66%) Chloramphenicol(10%) Vancomycin(3.33%). The high prevalence of antibiotic resistant staphylococcal isolates found in raw meat samples in this study becomes a major health concern for the butchers as well as consumers.
Foie et syndromes myéloprolifératifs.

LES MANIFESTATIONS HÉPATIQUES DES SYNDROMES MYÉLOPROLIFERATIFS • Hépatomégalie • Hypertension portale par hyperhémie sanguine splénique • Hypertension portale par bloc intrahépatique Métaplasie sinusoïdale Fibrose périsinusoïdale et sclérose hépatoportale • Hypertension portale par bloc sus-hépatique : syndrome de Budd-Chiari • Hypertension portale par bloc sous-hépatique : thrombose de la veine porte • Atteintes hépatiques et traitement des syndromes myéloprolifératifs
Controlled in situ synthesis of Bi 2 S 3 /ZnS nano film and its photoelectrochemical and photoresponsive performances

Novel Bi 2 S 3 and Bi 2 S 3 /ZnS thin films have been synthesized through an in situ synthesis method at room temperature. Wide ban d gap ZnS and narrow band gap Bi 2 S 3 composite to form heterojunction can show more excellent optoelectronic properties. The Bi 2 S 3 /ZnS thin films were then fabricated on FTO substrate, and this resulted in photocurrent to increase by 6 times compared to Bi 2 S 3 thin films. Especially, response time and recovery time of the photodetectors was 0.04 s and 0.09 s, respectively. The photodetectors based on both semiconductor thin films show the features of linear photocurrent characteristics and good sensitivity.
Unveiling the food webs of tetrapods across Europe through the prism of the Eltonian niche

Despite recent calls for integrating interaction networks into the study of large‐scale biodiversity patterns, we still lack a basic understanding of the functional characteristics of large interaction networks and how they are structured across environments. Here, building on recent advances in network science around the Eltonian niche concept, we aim to characterize the trophic groups in a large food web, and understand how these trophic groups vary across space.