Miracle-dz/UniFAR-FTUs huggingface dataset:
Understanding persuasive elements in phishing e-mails: A categorical content and semantic network analysis

– The purpose of this paper is to provide an in-depth content analysis of phishing messages and to enhance understanding of them from a persuasive communication perspective. , – This study analysed phishing message content in a persuasion mechanism framework including message presentation and content (rational appeal, emotional appeal, reasoning type). It also used semantic network analysis to identify meaning structure. , – The results indicate that phishing messages used logical appeals, reasoning from cause, motivational appeals, appealing to safety needs, and emotional appeals to gain compliance. Semantic network analysis showed that two word clusters represent security and privacy. , – This study applied modern persuasion and deceptive communication theories to interpret phishing e-mails. The findings enhance relevant theories by including phishing e-mail cases. , – The results of this study can be utilised for developing phishing prevention techniques and phishing detection software. , – Past phishing detection studies only used a technological approach, whereas the current study provides a more comprehensive content-oriented and persuasion theory-based understanding of phishing messages.
Identification in the Ancient Protist Giardia lamblia of Two Eukaryotic Translation Initiation Factor 4E Homologues with Distinctive Functions

ABSTRACT Eukaryotic translation initiation factor 4E (eIF4E) binds to the m7GTP of capped mRNAs and is an essential component of the translational machinery that recruits the 40S small ribosomal subunit. We describe here the identification and characterization of two eIF4E homologues in an ancient protist, Giardia lamblia. Using m7GTP-Sepharose affinity column chromatography, a specific binding protein was isolated and identified as Giardia eIF4E2. The other homologue, Giardia eIF4E1, bound only to the m2,2,7GpppN structure. Although neither homologue can rescue the function of yeast eIF4E, a knockdown of eIF4E2 mRNA in Giardia by a virus-based antisense ribozyme decreased translation, which was shown to use m7GpppN-capped mRNA as a template. Thus, eIF4E2 is likely the cap-binding protein in a translation initiation complex. The same knockdown approach indicated that eIF4E1 is not required for translation in Giardia. Immunofluorescence assays showed wide distribution of both homologues in the cytoplasm. But eIF4E1 was also found concentrated and colocalized with the m2,2,7GpppN cap, 16S-like rRNA, and fibrillarin in the nucleolus-like structure in the nucleus. eIF4E1 depletion from Giardia did not affect mRNA splicing, but the protein was bound to Giardia small nuclear RNAs D and H known to have an m2,2,7GpppN cap, thus suggesting a novel function not yet observed among other eIF4Es in eukaryotes.
High SNR performance analysis of F-ESPRIT

A performance analysis of a recently derived method for harmonic retrieval is conducted. The algorithm, which is referred to as F-ESPRIT, has a frequency selective feature which enables the user to select data from frequency subbands in which the signal harmonics are known to reside. This way an efficient suppression of out-of-band disturbances is obtained without the need of explicit data prefiltering. A first order perturbation analysis is conducted, which results in a closed form expression of the mean square error of the parameter estimates. Monte Carlo simulations and the Cramer-Rao lower bound validate the derived expression empirically.
Psychological Traits and Serum Lipids: I. Findings from the California Psychological Inventory

&NA; The California Psychological Inventory (CPI) was administered to 34 California firemen. Serum cholesterol levels had significant correlations with CPI scales which measure the degree to which the person had internalized social norms ("socialization"), his sense of responsibility, and self‐criticism. The multiple regression coefficient predicting the cholesterol level from Socialization and Self‐acceptance scores was 0.66. The two CPI scales were then administered to 152 male supermarket employees in Georgia. The CPI Socialization scale again had a statistically significant association with the cholesterol level (two‐way analysis of covariance), but raised the multiple correlation coefficient only marginally. The clinical interpretation of these findings is that the man who is particularly adherent to social norms, places high value on being dependable and conscientious, and is self‐critical, is more likely to have a higher serum cholesterol level. Furthermore, the influence of this personality syndrome differs in strength depending on the age and social characteristics of the group.
The role of general practice in cancer care.

BACKGROUND The incidence of cancer is rising, so the workload of managing cancer is increasing rapidly. Among the advances in cancer care are advances in coordination of care, with team care being a preferred method. OBJECTIVE This article examines the role of the general practitioner, by looking at each step in the patient's cancer journey. The current role of the GP and practice staff is examined, as well as potential roles that can be undertaken to maximise the role of general practice in an integrated cancer service. DISCUSSION A complete rethink of how cancer is managed, in particular defining the roles that must be performed by specialists and those that can be performed in primary care, needs to take place in order to deal with the rising cancer incidence in Australia. General practice must prepare to modify how it works to meet this challenge, in a similar way to confronting the rising tide of other chronic illnesses.
Toxicity of copper to Escherichia coli in relation to incubation temperature and method of sterilization of media.

The growth of Escherichia coli ATCC 9637 in a basal synthetic medium was very similar in cultures incubated at 35, 37, 40, and 42 °C. The inclusion in the medium of copper at concentrations of 0.1 and 0.2 μg/ml resulted in a decrease in the growth rate at each of these temperatures; the higher the temperature, the greater the decrease. Copper caused a decrease in the growth rate of E. coli in the medium sterilized by filtration as well as in that sterilized by autoclaving. However, in the medium sterilized by heat there were alternate periods in which the optical density (O.D.) of culture increased and periods during which no increase in O.D. occurred. Decreases of 50% or more in the numbers of viable cells occurred in conjunction with the plateaus in the O.D. of the cultures. A greater delay in the initiation of growth occurred in both the copper-free and the copper-containing media sterilized by heat than in the corresponding medium sterilized by filtration; the longer the exposure of the medium to heat.
The subthreshold behavior of SOS MOST's

MOST subthreshold behavior is of importance in many modern dynamic and very-low-power circuits. SOS MOST's exhibit quite generally a lower transconductance than bulk Si MOST's. Comparison between SOS and bulk Si MOST's is made on the basis of a simple model in the weak inversion region. Experiments with n-and p-channel SOS MOST's fabricated with epi Si layer thicknesses ranging from 0.1 to 3 µm confirm the predicted decrease of transconductance in weak inversion with decreasing thickness. Quantitative agreement between model and experience is obtained if a ∼350-Å thick nonconductive Si layer near the Si-sapphire interface is assumed. A transconductance jump observed for epi Si thickness equal to the surface maximum depletion width has not yet been explained. Further experiments including fabrication process, back-gate voltage measurements, and device dimensions were performed in order to investigate the low-transconductance origin. It is concluded that the only relevant parameters are the epi Si layer thickness and the high density of fast states at the Si-sapphire interface.
Improving the Communication Pattern in Matrix-Vector Operations for Large Scale-Free Graphs by Disaggregation

Matrix-vector multiplication is the key operation in any Krylov-subspace iteration method. We are interested in Krylov methods applied to problems associated with the graph Laplacian arising from large scale-free graphs. Computations with graphs of this type on parallel distributed-memory computers are challenging. This is due to the fact that scale-free graphs have a degree distribution that follows a power law, and currently available graph partitioners are not efficient for such an irregular degree distribution. The lack of a good partitioning leads to excessive interprocessor communication requirements during every matrix-vector product. We present an approach to alleviate this problem based on embedding the original irregular graph into a more regular one by disaggregating (splitting up) vertices in the original graph. The matrix-vector operations for the original graph are performed via a factored triple matrix-vector product involving the embedding graph. Even though the latter graph is larger, we .
Oral Contraceptives and Hypertension: A Report From the Boston Collaborative Drug Surveillance Program

The relation of admission blood pressure (BP) to oral contraceptive (OC) use was studied in 921 premenopausal women free of chronic disease with no history of hypertension who were hospitalized for acute illness or elective surgery. Case-control analysis revealed the relative risk of hypertension (systolic BP ≥ I4O or diastolic BP ≥ 90) among OC users to be 1.46 (P< .05). The age-adjusted mean BP among OC users was higher than among nonusers, but the difference was not statistically significant. In both OC users and nonusers, systolic and diastolic BP's were positively correlated with age (r=0.2, P< .001). The findings suggest that among apparently healthy females, OCinduced hypertension affects relatively few individuals and is usually mild in degree.
The hyperpolarization which follows activity in mammalian non‐medullated fibres

A period of repetitive activity in mammalian tnon-medullated fibres usually produces profound after-effects: under suitable conditions the size of the recorded action potential increases twoor threefold after a burst of activity, there is a large increase in the duration of the action potential and there is a prolonged hyperpolarization of the membrane (Brown & Holmes, 1956; Ritchie & Straub, 1956). It has recently been shown that the increase in the size of the action potential is a result of the increased duration of the action potential (Ritchie & Straub, 1956), as was predicted by Gasser (1950). There is no evidence for any large increase in the absolute size of the spike (Ritchie & Straub, 1956). The increased duration of the action potential is apparently entirely due to the appearance of a long-lasting, slow, negative after-potential which develops at the end of the spike; and it was concluded that the negative after-potential following the post-tetanic spike in turn resulted from the posttetanic hyperpolarization (Ritchie & Straub, 1956). The post-tetanic hyperpolarization is thus the underlying cause of many of the electrical phenomena of mammalian non-medullated nerve. In the present experiments the post-tetanic hyperpolarization has been studied and its production has been shown to be closely linked to the specific mechanism for the extrusion of intracellular sodium ions.
SUPPRESSION OF CONTACT HYPERSENSITIVITY BY UV RADIATION AND ITS RELATIONSHIP TO UV‐INDUCED SUPPRESSION OF TUMOR IMMUNITY

Abstract— In this study, we examine some of the photobiologic and immunologic characteristics of the suppression of contact hypersensitivity (CHS) by UV radiation. BALB/c mice were irradiated on the shaved dorsal skin with FS40 sunlamps and sensitized 5 days later by applying a contact sensitizer lo the shaved abdomen. The suppression of CHS resulting from exposure to a given total dose of UV radiation was unaffected by changes in dose fractionation over a 5‐day period and by changes in dose‐rate over a 10‐fold range. Elimination of wavelengths below 315 nm with a mylar filter abrogated the suppressive effect of the sunlamps, even when the same total energy was administered. Irradiation of unshaved mice required 14 times more energy to produce 50% suppression than was required for shaved mice, suggesting that the exposed skin is the primary target of this effect. Contact sensitization of UV‐irradiated, but not unirradiated, mice induced the appearance of antigen‐specific suppressor T lymphocytes in their spleen. The photobiologic and immunologic similarities between the suppression of CHS by UV radiation and the UV‐mediated suppression of tumor rejection that we described previously suggest that these two immunosuppressive effects of UV exposure share certain steps in their pathways.
Contribution of the C30/C75 disulfide bond to the biological properties of onconase

Abstract Onconase, a member of the pancreatic type ribonuclease family, is currently used as a chemotherapeutic agent for the treatment of different types of cancer. It is widely accepted that one of the properties that renders this enzyme cytotoxic is its ability to evade the cytosolic ribonuclease inhibitor (RI). In the present work, we produced and characterized an onconase variant that lacks the disulfide bond C30/C75. This variant mimics the stable unfolding intermediate des(30–75) produced in the reductive unfolding pathway of onconase. We found that the reduction of the C30/C75 disulfide bond does not significantly alter the cytotoxic properties of onconase, although the variant possesses a notably reduced conformational stability. Interestingly, both its catalytic activity and its ability to evade RI are comparable to wild-type onconase under mild reductive conditions in which the three disulfide containing intermediate des(30–75) is present. These results suggest that the C30/C75 disulfide bond could easily be reduced under physiological redox conditions.
PERIODIC OPTICAL VARIABILITY OF RADIO-DETECTED ULTRACOOL DWARFS

A fraction of very low mass stars and brown dwarfs are known to be radio active, in some cases producing periodic pulses. Extensive studies of two such objects have also revealed optical periodic variability, and the nature of this variability remains unclear. Here, we report on multi-epoch optical photometric monitoring of six radio-detected dwarfs, spanning the ∼M8–L3.5 spectral range, conducted to investigate the ubiquity of periodic optical variability in radio-detected ultracool dwarfs. This survey is the most sensitive ground-based study carried out to date in search of periodic optical variability from late-type dwarfs, where we obtained 250 hr of monitoring, delivering photometric precision as low as ∼0.15%. Five of the six targets exhibit clear periodicity, in all cases likely associated with the rotation period of the dwarf, with a marginal detection found for the sixth. Our data points to a likely association between radio and optical periodic variability in late-M/early-L dwarfs, although the underlying physical cause of this correlation remains unclear. In one case, we have multiple epochs of monitoring of the archetype of pulsing radio dwarfs, the M9 TVLM 513−46546, spanning a period of 5 yr, which is sufficiently stable in phase to allow us to establish a period of 1.95958 ± 0.00005 hr. This phase stability may be associated with a large-scale stable magnetic field, further strengthening the correlation between radio activity and periodic optical variability. Finally, we find a tentative spin–orbit alignment of one component of the very low mass binary, LP 349−25.
The epineural sheath of a nerve as a barrier to the diffusion of phosphate ions.

It was shown by Feng & Gerard (1930) that the connective tissue sheath of a nerve acts as a diffusion barrier. They recorded the action potential from nerves with and without sheaths after soaking in different solutions, and observed the time that elapsed before conduction was blocked. Lorente de No (1947) adopted a similar procedure, but measured the time required for the beginning of depolarization. He concluded that the 'penetration of substances across the connective tissue sheath takes place with great rapidity' (Lorente de No, 1950) and, further, in the same paper, that 'the epineurium is not a significant diffusion barrier'. Feng & Liu (1949) re-examined the problem and were able to confirm the original findings of Feng & Gerard, and their conclusions that 'the connective tissue sheath of amphibian sciatic nerve is an effective diffusion barrier' is now widely accepted (Hodgkin, 1949; Rashbass Rushton, Huxley Stampfli, Schoepfle, The difference of opinion shown in the papers of Feng and Lorente de No may be due to a lack of investigation into the identity of the tissues removed by different investigators.
How backhaul networks influence the feasibility of coordinated multipoint in cellular networks [Accepted From Open Call]

Interference is one of the most challenging problems in current cellular mobile access networks. Coordinated nultipoint transmission/ reception, and in particular joint processing, has proven to be a beneficial solution for interference management. Most research so far has investigated the requirements and gains on the wireless side but only superficially showed the impact on and requirements for the backhaul network. We take a different approach by looking at different backhaul topologies and technologies, and analyzing how they can support CoMP cooperation schemes. We study, for different traffic scenarios and backhaul connectivity levels, which base station clusters are actually feasible compared to the ones desirable from the radio access network perspective. We found out that a significant mismatch exists between the desired wireless clusters, as defined by the RAN, and feasible ones, as allowed by the given backhaul characteristics. Based on these findings, we explain how RAN clustering and backhaul clustering have to cooperate to come to feasible solutions. As one possible solution, we present a backhaul network preclustering scheme, which is able to predict which BSs are actually eligible for cooperation during the runtime of the network. The gains of this approach are quantifiable in terms of reduced signaling and user data exchange, and reduced MIMO signal processing.
Psychology of the Surgical Patient*

service perform important duties at the clinic, in the home, and sometimes in the hospital. It would be unfortunate if, in a matter which is confessedly difficult and even delicate, we should through lack of the spirit of conciliation and statesmanship fail in our effort to reach the aim accepted by us all as the ultimate desideratum-the unbroken continuity and singleness of control of the woman throughout the whole of her time of pregnancy, labour, and puerperium.
Association of DNA methyltransferases expression with global and gene‐specific DNA methylation in colorectal cancer cells

There are conflicting reports regarding the association between DNA methyltransferases (DNMTs) expression and global or gene‐specific DNA methylation in colorectal cancer (CRC) cells. To correlate DNMTs expression with DNA methylation, we quantified DNMT1, DNMT3A and DNMT3B mRNA levels in five CRC cell lines (HCT116, LS180, HT29/219, Caco2 and SW742) by real‐time reverse‐transcriptase polymerase chain reaction (PCR) assay. In addition, we examined the global 5‐methyl cytosine levels and the methylation patterns of 12 CpG islands in these CRC cells by enzyme‐linked immunosorbent assay and methylation‐specific PCR methods, respectively. The average expression levels of three DNMTs in HCT116, Caco2, HT29/219 and SW742, relative to the expression level in LS180 (taken to be 1), were 90·1, 31·6, 2·66 and 1·86. Our data indicated that overall about 1·45%, 1·03%, 0·98%, 0·86% and 0·85% of the cytosines were methylated in the genome of HCT116, Caco2, HT29/219, SW742 and LS180 cells, respectively. The 5‐mC percentages were positively correlated with the relative cellular DNMTs expression in five CRC cell lines as verified by Pearson correlation test. However, we found no positive correlation between mRNA expression of DNMTs and gene promoter hypermethylation in these cells. Our results suggest that cellular DNMT expression is positively correlated with global DNA methylation level but not with regional DNA hypermethylation at each locus. Copyright © 2015 John Wiley & Sons, Ltd.
The Australian experience in sun protection and screening for melanoma

Australia has the world's highest incidence of skin cancer. Despite excellent prevention and early diagnosis education programs and an increasing percentage of the population with darker and more UV tolerant skins, skin cancer remains a major and expensive community medical problem. However, primary and secondary prevention programs are now showing positive outcomes, especially in melanoma incidence and survival. Primary and secondary prevention programs are conducted by a variety of non‐government organizations such as the Australian Cancer Council, which is comprised of state anticancer groups, with some assistance from State and Federal health agencies. Current and future campaigns are becoming focused on specific community groups, noticeably teenagers and the older population. The role of sunscreens as the primary preventative approach has been superceded by sunlight avoidance campaigns. In light of an increasing rate of early diagnosis, a low and falling morbidity of melanoma, improving general practitioner competence in skin cancer diagnosis and proliferation of skin cancer clinics throughout Australia, it is unlikely a national skin cancer screening program will be implemented.
Effect of Air Pollution on Blood Pressure, Blood Lipids, and Blood Sugar: A Population-Based Approach

Objective: To investigate changes in blood pressure, lipids, and sugar associated with changes in exposure to ambient air pollution. Methods: We conducted secondary analyses of blood pressure and biochemistry markers from Taiwanese Survey on Prevalence of Hyperglycemia, Hyperlipidemia, and Hypertension and air pollution monitoring data in 2002 by applying generalized additive models. Results: We observed increased particulate matter with aerodynamic diameters <10 &mgr;m was associated with elevated systolic blood pressure (an interquartile range, 34 &mgr;g/m3, for 0.47 mmHg; 95% CI, −0.09 to 1.02), triglyceride, apolipoprotein B, hemoglobin A1c, and reduced high-density lipoprotein cholesterol. Elevated ozone was associated with increased diastolic blood pressure, apolipoprotein B, and hemoglobin A1c. Conclusions: Alterations of atherosclerotic indicators are associated with particulate matter with aerodynamic diameters <10 &mgr;m and ozone changes. This might provide a link between air pollution and progression of atherosclerotic cardiovascular diseases.
Random Permutation Online Isotonic Regression

We revisit isotonic regression on linear orders, the problem of fitting monotonic functions to best explain the data, in an online setting. It was previously shown that online isotonic regression is unlearnable in a fully adversarial model, which lead to its study in the fixed design model. Here, we instead develop the more practical random permutation model. We show that the regret is bounded above by the excess leave-one-out loss for which we develop efficient algorithms and matching lower bounds. We also analyze the class of simple and popular forward algorithms and recommend where to look for algorithms for online isotonic regression on partial orders.