Miracle-dz/UniFAR-FTUs huggingface dataset:
Working Set Model for Multithreaded Programs

Knowledge of the working set of pages associated with an application provides an opportunity for effective allocation of resources in multicore multiprocessor systems. Various techniques for approximating the working set size using either simulations or program traces have been proposed. However, these techniques are very expensive, and therefore not practical for dynamically optimizing resources. To alleviate this problem, in this work, we develop a statistical model based on machine learning techniques for approximating the working set size of multithreaded programs running on multicore multiprocessor systems. The basic idea is to correlate the working set size of a program with its resource usage characteristics, such as resident set size and TLB miss rate. Through extensive experimentation with 20 multithreaded programs from SPEC OMP2012 and PARSEC on a SPARC T4-4 running Oracle Solaris 11™, we demonstrate that the model has 96% prediction accuracy and its overhead is negligible.
Human bronchoalveolar lavage fluid protein two‐dimensional database: Study of interstitial lung diseases

Recently, we published an analytical two‐dimensional electrophoresis (2‐DE) protein map of human bronchoalveolar lavage fluid (BALF) using a pool of BALFs from various patients. In this report, the effect of lung disorders on the protein composition of the lung epithelial lining fluid was investigated by 2‐DE of BALFs from individual patients with well‐defined interstitial lung diseases: sarcoidosis, idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP), using improved experimental conditions. On these gels, about 600—1000 stained protein spots could be identified in a BALF sample containing 25 μg of protein, and our original human BALF protein database has, therefore, been considerably extended. Altogether, 429 protein spots corresponding to 66 different proteins (including isoforms, protein subunits and fragments) were identified by microsequence analysis and by matching with a human blood plasma 2‐DE protein map available in the SWISS‐2DPAGE database. A human 2‐DE BALF database was established and is available on the World Wide Web (http://www.umh.ac.be/˜biochim/proteomic.htm). The significance of the modifications observed between the different lung pathologies is discussed with the aim of understanding the mechanistic bases of lung disease pathogenesis and finding new potential lung markers of disorders.
Ischemic accidents in the middle cerebral artery territory. A study of the causes in 122 cases.

THE causes of ischemic accidents in the territory of the middle cerebral artery (MCA) may be conveniently considered under three headings: MCA occlusion or stenosis, internal carotid artery (ICA) occlusion or stenosis, and cases in which no arterial abnormality is found. MCA occlusions have for long been mainly ascribed by clinicians to cardiac embolism or to thrombosis. However postmortem studies have suggested that MCA thrombosis is less frequent than was formerly thought.1,2It is well established that atherosclerotic thrombosis is by far the main etiological factor of ICA occlusions, at least in western societies. Nevertheless, particularly in younger people, there remains a rather important number of cases in which no firm etiological clue can be clinically found.3 Cases with no or slight arterial abnormality have for long been ascribed to such disorders as spasm or fall in systemic pressure. Adams and Fisher4have, however, mentioned that
Power optimization through edge reduction in LUT-based FPGA technology mapping

This paper considers the problem of lookup table (LUT) based FPGA technology mapping for power minimization in combinational circuits. The problem has been previously proved to be NP-hard, and hence we present an efficient heuristic algorithm, PowerMap_er. This paper describes a technique that reduces power consumption by reducing the edge count in mapped network. The purpose of this technique is to reduce edge and power by considering routability in early steps of the CAD flow. Since routability can be improved by reducing edge count in mapping, power would be optimized after placement and routing. The main idea of our algorithm is to exploit the “cut enumeration” technique. Moreover, iterations of area and edge recoveries are deployed, and more effective edge cost function is proposed. The experimental results indicate that our algorithm reduces the average power consumption by up to 18.1%, the edge number by up to 10%, and the average number of LUTs by up to 6.8 % over an existing MacroMap algorithm. And compared to PowerMinMap-d [15], we achieved 12.74% power savings and 15.66% area reduction.
Description of Ancylomarina subtilis gen. nov., sp. nov., isolated from coastal sediment, proposal of Marinilabiliales ord. nov. and transfer of Marinilabiliaceae, Prolixibacteraceae and Marinifilaceae to the order Marinilabiliales.

A Gram-stain-negative, facultatively anaerobic, moderately halophilic, filamentous, non-motile bacterium, designated FA102T, was isolated from marine sediment from the coast of Weihai, PR China. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain FA102T formed a distinct evolutionary lineage within the family Marinifilaceae and its closest relative was Marinifilum fragile JCM 15579T (93.2 % sequence similarity). The DNA G+C content of the novel strain was 36.5 mol%. The predominant cellular fatty acids and respiratory quinone were iso-C15 : 0 and iso-C15 : 0 3-OH, and MK-7, respectively. On the basis of the phylogenetic, phenotypic and physiological data, strain FA102T represents a novel genus and species, for which the name Ancylomarina subtilis gen. nov., sp. nov. is proposed. The type strain of Ancylomarina subtilis is FA102T (=KCTC 42257T=DSM 28825T=CICC 10902T). Furthermore, a new order named Marinilabiliales is proposed to accommodate three families previously classified in the order Bacteroidales. Marinilabiliales ord. nov. encompasses the families Marinilabiliaceae, Prolixibacteraceae and Marinifilaceae.
Immunochemical Characterization of Antisera to Rat Neurofilament Subunits

Abstract: Antisera raised to the 68,000, 145,000 and 200,000 molecular weight subunits of rat neurofilaments were used for immunochemical staining of polypeptides separated by one‐ and two‐dimensional gel electrophoresis. It was found that each antiserum reacts intensely with its corresponding neurofilament subunit and weakly with the other two subunits. All the antisera also react with a polypeptide of molecular weight 57,000 present in neurofilament‐rich preparations from both rat spinal cord and peripheral nerve. This polypeptide is different from either tubulin or vimentin and may represent a neurofilament breakdown product, since it varied in amount from preparation to preparation. The three antisera also reacted with the polypeptide subunits of chicken and goldfish neurofilament despite the considerable difference in molecular weight between these subunits and those of mammalian neurofilament. Key Words: Neurofilaments–Antibodies–Immunochemical. Autilio‐Gambetti L. et al. Immunochemical characterization of antisera to rat neurofilament subunits. J. Neurochem. 37, 1260‐1265(1981).
Ion-acoustic shocks with self-regulated ion reflection and acceleration

An analytic solution describing an ion-acoustic collisionless shock, self-consistently with the evolution of shock-reflected ions, is obtained. The solution extends the classic soliton solution beyond a critical Mach number, where the soliton ceases to exist because of the upstream ion reflection. The reflection transforms the soliton into a shock with a trailing wave and a foot populated by the reflected ions. The solution relates parameters of the entire shock structure, such as the maximum and minimum of the potential in the trailing wave, the height of the foot, as well as the shock Mach number, to the number of reflected ions. This relation is resolvable for any given distribution of the upstream ions. In this paper, we have resolved it for a simple “box” distribution. Two separate models of electron interaction with the shock are considered. The first model corresponds to the standard Boltzmannian electron distribution in which case the critical shock Mach number only insignificantly increases from .
The relationship between mission statements and corporate social performance

This paper has investigated the relationship between mission statement and corporate social performance of top 100 state-owed corporate in china. We found that corporate mission statement concern with customers and supplier, products and services, as well as technology and growth factors are significantly associated with the economic responsible performance, while the high frequency of image which concern with the nation, employee, societies and environmental included in mission statement are not significantly associated with social and environmental responsible performance. The result indicate that mission statement concern with image include issues of social and environmental are related to the needs of legitimacy, it is the reaction to the pressure of formal and informal institutions.
Stimulation of matrix metalloprotease 3 release from human chondrocytes by the interaction of stromal cell-derived factor 1 and CXC chemokine receptor 4.

OBJECTIVE The chemokine family of secreted proteins regulates cellular activities through interaction with G protein-coupled chemokine receptors. The aim of this study was to analyze the role of a chemokine stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4 in rheumatoid arthritis (RA) and osteoarthritis (OA) by examining their gene expression in joint cartilage and synovium and by determining the effect of their interaction on the release of matrix metalloproteases (MMPs) from chondrocytes. METHODS SDF-1 protein levels in synovial fluid from the knee joints of 58 RA patients, 55 OA patients, and 60 control patients without arthritis were quantified by enzyme-linked immunosorbent assay. SDF-1 and CXCR4 messenger RNA (mRNA) levels in chondrocytes and synovial fibroblasts were determined by reverse transcriptase-polymerase chain reaction. Isolated human chondrocytes were stimulated with 100 ng/ml of SDF-1, and the response was analyzed by quantifying the release of MMPs 1 and 3. RESULTS We found that the concentration of SDF-1 in synovial fluid increased 3.57-fold in OA patients and 10.71-fold in RA patients compared with normal controls. The source of SDF-1 in synovial fluid was synovium, since SDF-1 mRNA was synthesized by synovial fibroblasts but not by chondrocytes. Conversely, CXCR4 was expressed by chondrocytes but not by synovial fibroblasts. The interaction of SDF-1, which was abundant in synovial fluid from RA and OA patients, with CXCR4-positive chondrocytes resulted in a specific elevation of the release of the cartilage matrix-degrading enzyme MMP-3 (stromelysin 1). CONCLUSION Our findings suggest a novel mechanism by which synovial cells induce degradation of cartilage matrix through SDF-1 signaling in RA and OA.
Hyperalgesia during naloxone-precipitated withdrawal from morphine is associated with increased on-cell activity in the rostral ventromedial medulla.

Hyperresponsiveness to noxious stimulation (hyperalgesia) is observed with naloxone-precipitated morphine withdrawal in several experimental models, and may be due to changes in central nervous system neurons. Previous studies have demonstrated that certain neurons in the rostral ventromedial medulla (on-cells) discharge just prior to nocifensive withdrawal reflexes and are inhibited by morphine. Because the tail flick latency (TFL) is shorter when on-cells are active, it has been proposed that on-cells facilitate nocifensive reflexes. The present study examined the hypothesis that the hyperalgesia observed following naloxone-precipitated withdrawal from morphine is caused by increased on-cell discharge. Rats were maintained in a lightly anesthetized state with chloral hydrate. Administration of saline (1.25 cc, i.v.) or morphine sulfate (1.25 mg/kg, i.v.) was followed by naloxone (1.0 mg/kg, i.v.). On- and off-cell activity was continuously recorded and was correlated with TFL and paw withdrawal threshold (PWT). As previously reported, morphine increased off-cell activity, blocked on-cell activity, and suppressed the tail flick and paw withdrawal reflexes. When naloxone was given after morphine, TFL and PWT were reduced to values significantly below baseline (hyperalgesia). Both spontaneous and reflex-related on-cell activity increased to levels greater than the premorphine baseline. Spontaneous off-cell activity decreased abruptly to near zero when morphine was followed by naloxone. Linear regression analysis during the hyperresponsive state revealed a significant correlation between increased on-cell activity and reduced TFL, but not between decreased off-cell activity and TFL. These findings are consistent with the hypothesis that on-cells facilitate spinal nocifensive reflexes, and that the naloxone-precipitated hyperalgesia is at least in part accounted for by increased on-cell activity. A neural model of opiate dependence, tolerance, and withdrawal is proposed.
The role of the range parameter for estimation and prediction in geostatistics

Two canonical problems in geostatistics are estimating the parameters in a specified family of stochastic process models and predicting the process at new locations. We show that asymptotic results for a Gaussian process over a fixed domain with Matern covariance function, previously proven only in the case of a fixed range parameter, can be extended to the case of jointly estimating the range and the variance of the process. Moreover, we show that intuition and approximations derived from asymptotics using a fixed range parameter can be problematic when applied to finite samples, even for large sample sizes. In contrast, we show via simulation that performance is improved and asymptotic approximations are applicable for smaller sample sizes when the parameters are jointly estimated. These effects are particularly apparent when the process is mean square differentiable or the effective range of spatial correlation is small. Copyright 2013, Oxford University Press.
An overall structure optimization for a light-weight robotic arm

The application of lightweight robotic arms is having been expanded from factory automation to the service areas. It is significant to make lightweight robotic arms much safer and lighter for human-robot co-existence. This study presents an overall structure optimization design approach to minimize the mass of the lightweight robotic arm with the constraints on structural strength and drive trains. This method is implemented by integrated co-simulation analysis and the complex method. In this paper, a parameterized model of the robotic arm is established for optimization design. Then, the complex method is utilized to obtain the optimal design of the robotic arm. Meanwhile, a co-simulation analysis platform based on ANSYS Workbench and ADAMS is built to evaluate the constraints. Finally, a design example is illustrated to demonstrate the application of the proposed approach in design of a five degree-of-freedom lightweight robotic arm.
Identification of the site of interaction of the dihydropyridine channel blockers nitrendipine and azidopine with the calcium‐channel alpha 1 subunit.

The dihydropyridine binding site of the rabbit skeletal muscle calcium channel alpha 1 subunit was identified using tritiated azidopine and nitrendipine as ligands. The purified receptor complex was incubated either with azidopine or nitrenidpine at an alpha 1 subunit to ligand ratio of 1:1. The samples were then irradiated by a 200 W UV lamp. The ligands were only incorporated into the alpha 1 subunit, which was isolated by size exclusion chromatography and digested either by trypsin (azidopine) or endoproteinase Asp‐N (nitrendipine). Each digest contained two radioactive peptides, which were isolated and sequenced. The azidopine peptides were identical with amino acids 13–18 (minor peak) and 1428–1437 (major peak) of the primary sequence of the skeletal muscle alpha 1 subunit. The nitrendipine peptides were identical with amino acids 1390–1399 (major peak) and 1410–1420 (minor peak). The sequence from amino acids 1390 to 1437 is identical in the alpha 1 subunits of skeletal, cardiac and smooth muscle and follows directly repeat IVS6. These results indicate that dihydropyridines bind to an area that is located at the putative cytosolic domain of the calcium channel.
Down-Regulation of ZmEXPB6 (Zea mays β-Expansin 6) Protein Is Correlated with Salt-mediated Growth Reduction in the Leaves of Z. mays L.

Background: Maize shows a rapid leaf growth reduction upon salinity, being a thread to global food security. Results: Exogenous application of Zea mays β-expansin 6 partially restores growth. Conclusion: ZmEXPB6 improves growth by acting on the capacities of cell walls to extend. Significance: A strategy to improve growth under saline conditions was shown. This knowledge can be useful for developing crops with a better performance under salinity. The salt-sensitive crop Zea mays L. shows a rapid leaf growth reduction upon NaCl stress. There is increasing evidence that salinity impairs the ability of the cell walls to expand, ultimately inhibiting growth. Wall-loosening is a prerequisite for cell wall expansion, a process that is under the control of cell wall-located expansin proteins. In this study the abundance of those proteins was analyzed against salt stress using gel-based two-dimensional proteomics and two-dimensional Western blotting. Results show that ZmEXPB6 (Z. mays β-expansin 6) protein is lacking in growth-inhibited leaves of salt-stressed maize. Of note, the exogenous application of heterologously expressed and metal-chelate-affinity chromatography-purified ZmEXPB6 on growth-reduced leaves that lack native ZmEXPB6 under NaCl stress partially restored leaf growth. In vitro assays on frozen-thawed leaf sections revealed that recombinant ZmEXPB6 acts on the capacity of the walls to extend. Our results identify expansins as a factor that partially restores leaf growth of maize in saline environments.
Individual and combined phytotoxic effects of cadmium, lead and arsenic on soybean in Phaeozem

Acute laboratory toxicity tests were carried out to assess the individual and combined toxic effects of metals including cadmium (Cd), lead (Pb) and the metalloid arsenic (As) in Phaeozem on the seed germination and seedling growth of soybean, Glycine max. Seeds were exposed to varied concentrations of Cd, Pb and As individually and in mixtures including Cd + Pb, Cd + As, Pb + As and Cd + Pb + As. The sum of toxic units (TU) for medium effective concentration of the mixture (EC 50mix ) was calculated based on the dose (TU-based)-response relationship using the Trimmed Spearman-Karber method. Binary metal combinations of Cd + Pb, Cd + As and Pb + As produced additive, synergistic and antagonistic effects, respectively, on shoot growth and synergistic, synergistic and antagonistic effects on root growth. Ternary combination of Cd + Pb + As had a synergistic effect on shoot growth and an additive effect on root growth. Bioaccumulation of metals was observed in soybean and inhibited or enhanced bioaccumulations of individual metals were found in mixtures due to different combinations of metals.
Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation*

Dynamic inactivation in Kv4 A-type K+ current plays a critical role in regulating neuronal excitability by shaping action potential waveform and duration. Multifunctional auxiliary KChIP1–4 subunits, which share a high homology in their C-terminal core regions, exhibit distinctive modulation of inactivation and surface expression of pore-forming Kv4 subunits. However, the structural differences that underlie the functional diversity of Kv channel-interacting proteins (KChIPs) remain undetermined. Here we have described the crystal structure of KChIP4a at 3.0Å resolution, which shows distinct N-terminal α-helices that differentiate it from other KChIPs. Biochemical experiments showed that competitive binding of the Kv4.3 N-terminal peptide to the hydrophobic groove of the core of KChIP4a causes the release of the KChIP4a N terminus that suppresses the inactivation of Kv4.3 channels. Electrophysiology experiments confirmed that the first N-terminal α-helix peptide (residues 1–34) of KChIP4a, either by itself or fused to N-terminal truncated Kv4.3, can confer slow inactivation. We propose that N-terminal binding of Kv4.3 to the core of KChIP4a mobilizes the KChIP4a N terminus, which serves as the slow inactivation gate.
Muscle NIRS Signals vs. Venous Blood Hemoglobin Oxygen Saturation in Skeletal Muscle.

PURPOSE To examine the relationship between near infrared spectroscopy (NIRS) signals and venous hemoglobin oxygen saturation (O2Hb%) and venous oxygen concentration (CvO2). METHODS Gastrocnemius muscles (GS) in six dogs were surgically isolated and pump perfused. NIRS signals were recorded and venous blood samples were collected at constant flow rates (Control Flow, High Flow and Low Flow) at rest as well as during electrically stimulated tetanic muscle contractions at rates of 1 contraction/2 s (1/2 s) and 2 contractions/3 s (2/3 s). Similar data were also collected at three different inspired O2 percentages (12%, 21%, and 100%) with constant blood flow. RESULTS Complete data from five animals were analyzed; all data from one animal were deleted because of erratic oxy-NIRS signals. Venous O2Hb% ranged from 7.6% to 97.5% across the various experimental conditions. After the NIRS signals were normalized to the physiological range, a high linear correlation was seen between the deoxygenated heme signal (HHbMb%) and venous O2Hb% (R = 0.92 ± 0.05), between the oxygenated heme signal (HbMbO2%) and venous O2Hb% (R = 0.92 ± 0.03), between HHbMb% and CvO2 (R = 0.89 ± 0.06), and between HbMbO2% and CvO2 (R = 0.90 ± 0.05). The overall relationships between HHbMb%, HbMbO2% and venous O2Hb%, as well as between HHbMb%, HbMbO2% and CvO2 were also linear and highly correlated with R values ranging from 0.81 to 0.90. CONCLUSION In this controlled canine muscle model, NIRS signals are highly correlated with venous O2Hb% and CvO2 across a wide range of physiological conditions. The practical application of our results is that for an individual muscle or perhaps muscle group, normalized NIRS HHbMb and HbMbO2 signals accurately reflect the mean venous O2 saturation of the interrogated muscle tissue.
Epstein frame measurement based determination of original non-degraded and fully degraded magnetic properties of material submitted to mechanical cutting

The cutting process has a substantial influence on the ferromagnetic material properties of electrical steel sheets. In this paper, the properties of the degraded and non-degraded zones result from data obtained by two Epstein frame measurements using sample strips of two different widths. The magnetic characteristics of the degraded and non-degraded material are inserted into a finite-element model, which accounts for arbitrary geometries. The simulation results for the influence of degradation on a stator lamination stack are verified by measurements at three different frequencies and two different materials.