Miracle-dz/UniFAR-FTUs huggingface dataset:
Heart failure in a breast cancer survivor.

147 A 64-year-old woman named J.G. was diagnosed with a right side, node-negative, HER2-positive, hormone-negative (stage I) breast cancer about eight years ago. Following lumpectomy and sentinel node biopsy, she was referred to a medical oncologist at a National Cancer Institute–designated comprehensive cancer center for consultation on the need for adjuvant chemotherapy. The oncologist recommended four cycles of doxorubicin plus cyclophosphamide. Final trials for trastuzumab in the adjuvant setting had not been completed at the time of the consultation. And, because of the small size of the primary tumor (0.8 cm), the oncologist did not recommend trastuzumab, citing evolving concerns about cardiotoxicity related to long-term use of the drug. J.G. had a positive family history of cardiac events: Both of her parents died from sudden myocardial infarctions in their 60s and her older brother had congestive heart failure (CHF). J.G. had a personal history of hypertension (for which she declined antihypertensive treatment), was obese (body mass index of 38.4), and was sedentary. She agreed with the treatment plan as discussed with her oncologist. A prechemotherapy cardiac assessment of an electrocardiogram and multigated acquisition (MUGA) scan showed no cardiac problems. The MUGA scan’s result for left ventricular ejection fraction (LVEF) was 61% (normal is 50% or greater). J.G. proceeded with treatment, which she tolerated well. Following chemotherapy, she underwent six weeks of external beam radiation to her right breast with a boost to the tumor site. After completing adjuvant therapy, J.G. was seen regularly during a fiveyear period by her surgeon and medical oncologist. Two months ago, however, J.G. noted a sudden increase in fatigue. She had a persistent dry cough and was gaining weight without an increase in Heart Failure in a Breast Cancer Survivor
Electric control of tunneling energy in graphene double dots

We theoretically investigate the spectrum of a single electron double quantum dot, defined by top gates in a graphene with a substrate-induced gap. We examine the effects of electric and magnetic fields on the spectrum of localized states, focusing on the tunability of the interdot coupling. We find that the substrate-induced gap allows for electrostatic control, with some limitations that for a fixed interdot distance, the interdot coupling cannot be made arbitrarily small due to the Klein tunneling. On the other hand, the proximity of the valence band in graphene allows for new regimes, such as an npn double dot, which have no counterparts in GaAs.
Coupled Canonical Polyadic Decompositions and (Coupled) Decompositions in Multilinear Rank-(Lr, n, Lr, n, 1) Terms - Part I: Uniqueness

The coupled canonical polyadic decomposition (CPD) is an emerging tool for the joint analysis of multiple data sets in signal processing and statistics. Despite their importance, linear algebra based algorithms for coupled CPDs have not yet been developed. In this paper, we first explain how to obtain a coupled CPD from one of the individual CPDs. Next, we present an algorithm that directly takes the coupling between several CPDs into account. We extend the methods to single and coupled decompositions in multilinear rank-$(L_{{r,n}},L_{{r,n}},1)$ terms. Finally, numerical experiments demonstrate that linear algebra based algorithms can provide good results at a reasonable computational cost.
Identification of a YAC spanning the translocation breakpoint t(8;22) associated with acute monocytic leukemia

Using a series of yeast artificial chromosomes (YAC) from the 8p11‐12 chromosome region, we have analyzed a t(8;22) translocation present in two patients suffering from acute leukemia by using fluorescence in situ hybridization (FISH). We have identified a YAC that spans the breakpoint in both cases. Genes Chromosom Cancer 15:191–194 (1996). © 1996 Wiley‐Liss, Inc.
Comprehensive review of the diagnosis and treatment of biliary tract cancer 2012. PART I: Diagnosis‐clinical staging and pathology

Biliary tract cancers (gallbladder cancer, intra‐ and extra‐hepatic cholangiocarcinoma, and selected periampullary cancers) accounted for 12,760 new cases of cancer in the USA in 2010. These tumors have a dismal prognosis with most patients presenting with advanced disease. Early, accurate diagnosis is essential, both for potential cure where possible and for optimal palliative therapy in all others. This review examines the currently available and emerging technologies for diagnosis and treatment of this group of diseases. J. Surg. Oncol. 2012; 106:332–338. © 2012 Wiley Periodicals, Inc.
Emerald Article : Transformational leadership and personal outcomes : empowerment as mediator

Purpose – Creating and maintaining sustainable businesses require an understanding of the role of leadership in enhancing personal outcomes of employees, and of the processes by which they can be enhanced. The purpose of this paper is to report a study on analyzing how transformational leadership is related to followers’ meaning in life and subjective wellbeing, with psychological empowerment being a mediating variable. Design/methodology/approach – Data were collected from 285 managers (69 females and 215 males) of a large manufacturing organization in western India. They responded to questions about their superior’s transformational leadership and their own empowerment, meaning in life and wellbeing. Findings – Empowerment mediated the relationship between transformational leadership and follower’s meaning in life and wellbeing. Research limitations/implications – Same-source bias is a possible limitation of the study. Leader’s self-rating on transformational leadership could be taken, but it would not be as valid as the rating given by followers. Another limitation is the collection of all data at the same time. Practical implications – The strong and positive relationship between empowerment and meaning in life sheds light on making followers see greater meaning in life. Attempts to enhance meaning in life should first focus on increasing self-efficacy. If followers do not have faith in their own capability to do their job, it may not be possible for them to see meaning in life. Originality/value – This study adds to the existing literature by clarifying the process by which transformational leaders enhance followers’ meaning in life and subjective wellbeing.
Characterization of homofermentative lactobacilli isolated from kefir grains: potential use as probiotic

Considering that several health promoting properties are associated with kefir consumption and a reliable probiotic product requires a complete identification of the bacterial species, the present work evaluates several proved markers of probiotic potential of eleven isolates of homofermentative lactobacilli isolated from kefir grains and molecular identification and genotypic diversity. Using restriction analysis of amplified ribosomal DNA (ARDRA) and analysis of the 16S–23S rRNA internal spacer region we confirmed that all homofermentative lactobacilli belong to the species Lactobacillus plantarum. RAPD-PCR analysis allowed the discrimination of lactobacilli in five clusters. All isolates exhibited high resistance to bile salt. High survival after one hour of exposure to pH 2·5 was observed in Lb. plantarum CIDCA 8313, 83210, 8327 and 8338. All isolates were hydrophilic and non autoaggregative. Isolate CIDCA 8337 showed the highest percentage of adhesion among strains. All tested lactobacilli had strong inhibitory power against Salmonella typhimurium and Escherichia coli. Seven out of eleven isolates showed inhibition against Sal. enterica and five isolates were effective against Sal. gallinarum. Only CIDCA 8323 and CIDCA 8327 were able to inhibit Sal. sonnei. We did not find any correlation between the five clusters based on RAPD-PCR and the probiotic properties, suggesting that these isolates have unique characteristics.
Electrocardiographic and clinical characteristics of idiopathic restrictive cardiomyopathy in children.

BACKGROUND Idiopathic restrictive cardiomyopathy (RCM) is not a single disease and is rare. METHODS AND RESULTS The clinical features and clinical course of 12 pediatric patients with RCM seen between 1978 and 2005 were retrospectively analyzed. The age at diagnosis ranged from 4 months to 12 years (median 4 years). The age of 7 patients diagnosed because of an abnormal electrocardiogram (ECG) ranged from 4 to 12 years. Three infants less than 2 years old presented with cardiomegaly. Obliquely elevated ST-T segments and the late peak T waves on 12-lead ECG were present in 8 patients (67%). Three patients with ST depression during exercise had no perfusion defects on radioisotope myocardial perfusion imaging. Two patients underwent orthotopic heart transplantation. Of the remaining 10 patients, 7 have died: 4 died suddenly and 3 died of right heart failure. Three patients with a hypertrophic left ventricular wall had a prolonged survival. The probability of survival at 1, 2 and 3 years was 78%, 52% and 26%, respectively. CONCLUSIONS Obliquely elevated ST-T segments and the late peak T wave on ECG are characteristic, and reflect the restrictive physiology, which may indicate abnormalities of repolarization of ventricular muscle. The mode of death was either heart failure from pulmonary hypertension or sudden death from presumed ventricular arrhythmia.
Experimente mit XP in der Lehre

Wir berichten über unsere Erfahrungen beim versuchsweisen Einsatz von XP in Software-Entwicklungspraktika an der Universität. Mit der Projektplanung nach XP waren unsere wenig programmiererfahrenen TeilnehmerInnen teilweise überfordert, aber insbesondere die Konzepte von XP zur Verbesserung des Codes und der Kommunikation im Team haben sich sehr bewährt. Auf diese wollen wir auch in modellbasierten Projekten nicht mehr verzichten.
Temperature and atmospheric pressure may be considered as predictors for the occurrence of bacillary dysentery in Guangzhou, Southern China.

INTRODUCTION The control of bacillary dysentery (BD) remains a big challenge for China. METHODS Negative binomial multivariable regression was used to study relationships between meteorological variables and the occurrence of BD during the period of 2006-2012. RESULTS Each 1°C rise of temperature corresponded to an increase of 3.60% (95%CI, 3.03% to 4.18%) in the monthly number of BD cases, whereas a 1 hPa rise in atmospheric pressure corresponded to a decrease in the number of BD cases by 2.85% (95%CI = 3.34% to 2.37% decrease). CONCLUSIONS Temperature and atmospheric pressure may be considered as predictors for the occurrence of BD in Guangzhou.
Water quality parameters prediction method based on Self-Organization Neural Network

According the problem of difficult to measure online water quality parameters of activated sludge process wastewater treatment system, this paper proposed a new growth self-organization neural network. This network can dynamic generate network nodes and grow to suitable network structure rapidly according to need in the learning process no need to advance set the value the structure and scale. The water quality parameters model of wastewater treatment system based on this network, have more strong adaptive ability, can learning online, network structure is simple, learning velocity rapid, prediction effluent water COD concentration effectively according to input, which proved high effectiveness of this method.
Soft Tissue Response to Textured Silicone Implants in an Animal Experiment

In a study on rats to assess soft tissue response to textured silicone implants, ellipsoid 15 x 20 mm pieces from the bag of a Biocell® breast prosthesis were implanted under the dorsal skin. Histological examinations incluing immunohistochemical detection of myofibroblasts were made 2 weeks and 1, 3, 6, and 8 months after implantation (12 specimens for each time interval). On the smooth side of the implant, which served as a control, the thin connective tissue capsule characteristically seen with silicone elastomer implants developed within a month. Myofibroblasts were present after the first month and appeared to reach a peak 3 months after implantation, after which they showed marked regression. On the textured side of the implant, villous processes were a characteristic feature of the capsules; originating in a common basal layer, they penetrated into the cavities of the implant. Collagen deposits and myofibroblasts only became more evident during the third month after implantation; they were limited to the common basal layer of the capsule, though foreign body reaction persisted in the villous processes until the end of the experiment. The experimental study, limited to an 8-month period after implantation, showed that texturing of the implant surface prevents compact capsule development and considerably delays or inhibits the maturation process. (Plast. Reconstr. Surg. 92: 474, 1993.)
Model for the initiation of ionizing radiation-induced apoptosis in lymphoid cells by complex DNA double-strand breaks

Purpose : To present a model for the molecular events that lead to the induction of apoptosis in irradiated lymphoid cells based on the assumption that the process is triggered by complex DNA double-strand breaks (DSB). Outline of the model : •Cellular DNA repair mechanisms have difficulty rejoining complex DSB because of the nature of the end groups on such breaks. •Association between p53 and DNA topoisomerase I (topo I) can occur at complex DSB in open regions of the genome and the enzymic activity of such associations is not suppressed by polyADP-ribosylation. •Binding of p53 and topo I at a complex DSB results in the transient trapping of a DNA-topo I cleavage complex. •Transiently trapped DNA-topo I cleavage complexes at complex DSB are reversed following association with topo I bound elsewhere in the genome, thus initiating a misrejoining event. •Topo I-mediated DNA misrejoining creates a structure that activates p53. Initiation of rapid interphase apoptosis requires that the inducing signal from activated p53 exceeds a threshold level. •Initiation of rapid interphase apoptosis is regulated by poly(ADP-ribose) polymerase.
Fuzzy Modeling for the Prediction of Vasopressors Administration in the ICU Using Ensemble and Mixed Fuzzy Clustering Approaches

Severe sepsis and septic shock are major health care problems and remain one of the leading causes of death in critically ill patients. Therapy with vasopressor agents is usually initiated in this group of patients. The main objective of this work is to describe and implement a data mining solution to predict the need of vasopressors administration in septic shock patients in the Intensive Care Unit (ICU). MIMIC II database was used to extract clinical data from 32 physiological and 5 static variables for a cohort of patients of interest. Two different analysis were conducted using this data: patients’ clinical state and patients’ clinical evolution. The former group is studied under an ensemble modelling approach. Feature selection was performed for four different criteria, a priori, a posteriori, arithmetic mean and mean weighted distance, and for the single model. Ensemble approaches benefited from the feature selection, whereas the single model performs best with all the 32 input variables. The spatiotemporal analysis was approached using two different clustering techniques: Fuzzy C-means (FCM) and Mixed Fuzzy Clustering (MFC). The latter weights the relevance of the temporal component of data in the clustering process, allowing a more flexible identification of structures in datasets composed by mixed features (temporal and static). Two modeling approaches based on MFC were tested and compared with similar approaches based on the traditional FCM, where both clustering algorithms are used either for transforming the feature space of the input variables in membership degrees, or for determining the antecedent fuzzy sets of Takagi Sugeno fuzzy models. The use of feature transformation showed better performance than the other methods, however, when sequential feature selection is combined with fuzzy modeling, FCM is the best performer.Overall, the best results obtained are AUC=0.82±0.01 and AUC=0.80±0.06 for the ensemble and MFC strategies, respectively. Additionally, considering the fact that the imputation of data is around 14.6% in MFC and 74.7% in ensemble, MFC should be considered, preferentially, to predict vasopressors administration in critically ill patients.
A Novel Transcript Overlapping the Myelin Basic Protein Gene

Abstract: Myelin basic protein (MBP) is a major constituent of myelin synthesized by oligodendrocytes and Schwann cells. We have investigated the expression of mouse MBP RNAs outside the nervous system. Nuclease protection experiments indicate that RNAs containing exon 1 and not the six downstream exons of the MBP gene are transcribed in various hemopoietic tissues. We have isolated a hemopoietic MBP‐related (HMBPR) cDNA clone from a mouse bone marrow cDNA library screened with an MBP cDNA probe. This clone contains exons 1a and 1b and a part of intron 1 of the MBP gene. An additional 5’region, encoded by at least three unidentified exons, lies upstream of exon 1a. The HMBPR clone corresponds to a 5‐kb RNA expressed in bone marrow, spleen, thymus, and macrophagic cells. This transcript is expressed at a similar level in brain, although at a lower level than the classical 2‐kb mRNA. These data indicate that a new transcript, overlapping the MBP transcription unit and controlled by a distinct promoter, is expressed in hemopoietic tissues. This RNA might encode a 21‐kDa protein sharing a common domain with MBP.
Carrier‐Mediated Transport of Thyroid Hormones into Rat Glial Cells in Primary Culture

Abstract: The uptake of 3,3′,5‐[3′‐125I]triiodo‐L‐thyronine ([125I]L‐T3) and of L‐[3′,5′‐125I]thyroxine ([125I]L‐T4) by cultured rat glial cells was studied under initial velocity (Vi) conditions. Uptake of both hormones was carrier mediated and obeyed simple Michaelis‐Menten kinetics. The following respective values of Km (μM) and Vmax (fmol/min/μg of DNA) were obtained at 25°C: 0.52 ± 0.09 and 727 ± 55 for L‐T3 and 1.02 ± 0.21 and 690 ± 85 for L‐T4. Ki values (μM) for the inhibition of [125I]L‐T3 uptake by unlabeled analogues were as follows: L‐T4, 0.88; 3,3′,5′‐triiodo‐L‐thyronine, 1.4; 3,3′‐diiodo‐L‐thyronine, 2.9; 3,3′,5‐triiodo‐D‐thyronine, 4.8; and triiodothyroacetic acid, 5.3. These values indicate that the uptake system is stereospecific. Unlabeled L‐T3 was a better competitor than unlabeled L‐T4 for the uptake of [l25l]L‐T4, an observation suggesting that both hormones were taken up by a common carrier system. L‐T3 and L‐T4 uptake was pH dependent, a finding suggesting that the phenolic unionized form of the hormones was preferentially taken up. L‐T3 uptake was studied in the presence of various inhibitors; the results suggest that uptake was independent of the transmembrane Na+ gradient and of the cellular energy. Compounds that inhibited cellular uptake but were without effect on L‐T3 binding to isolated nuclei also inhibited L‐T3 nuclear binding in intact cells, an observation suggesting that uptake could be rate limiting for the access of L‐T3 to nuclear receptors when transport is severely inhibited.
Aspectos tomográficos e anatomopatológicos do padrão de pavimentação em mosaico

Objective: To describe high-resolution computed tomography findings in several diseases that run their course with the “crazy-paving” pattern. Materials and Methods: The present study has evaluated seven patients with diagnoses of alveolar proteinosis, bronchioloalveolar carcinoma, lipoid pneumonia and pneumocystosis, correlating tomographic and pathological findings. Results: In the cases of pneumocystosis, the alveolar spaces were filled with foamy material where parasitic organisms intermingled with surfactants, fibrin and cell debris were observed. In the cases of bronchioloalveolar carcinoma, the septa were thickened by associated fibrosis or lymphangitis, with the alveolar walls internally lined with tumor cells, and production of mucus. In the patient with alveolar proteinosis, the septa were thickened by edema, with alveolar filling determined by lipoprotein. In the patient with mineral oil aspiration, the histopathological findings included alveolar septa thickening caused by cell proliferation, with presence of fat vacuoles in alveolar septa. Conclusion: The crazy-paving pattern offers a wide range
ANÁLISE DE REQUISITOS PARA IMPLEMENTAÇÃO DE UMA FERRAMENTA DE AUTORIA PARA O DESENVOLVIMENTO DE OBJETOS DE APRENDIZAGEM PARA A ÁREA DA SAÚDE

Com a mudanca das diretrizes para o ensino da medicina no Brasil, os objetos de aprendizagem se tornaram importantes ferramentas pedagogico-didaticas, pois trazem a possibilidade da construcao de novos modelos organizativos do curriculo. Para construir esses elementos podem ser usadas ferramentas de autoria. O uso das ferramentas de autoria quase sempre exige conhecimentos avancados em informatica, tornando-se um processo complicado para a grande maioria dos profissionais da saude e do ensino. Neste artigo e proposta a analise para o desenvolvimento de uma ferramenta de autoria, tendo por base o estudo de ferramentas disponiveis atualmente, entrevista com professores da area da saude e os principais padroes de metadados existentes.
The influence of dielectric decrement on electrokinetics

Abstract We treat the dielectric decrement induced by excess ion polarization as a source of ion specificity and explore its impact on electrokinetics. We employ a modified Poisson–Nernst–Planck (PNP) model accounting for the dielectric decrement. The dielectric decrement is determined by the excess-ion-polarization parameter $\alpha $ and when $\alpha = 0$ the standard PNP model is recovered. Our model shows that ions saturate at large zeta potentials $(\zeta )$ . Because of ion saturation, a condensed counterion layer forms adjacent to the charged surface, introducing a new length scale, the thickness of the condensed layer $({l}_{c} )$ . For the electro-osmotic mobility, the dielectric decrement weakens the electro-osmotic flow owing to the decrease of the dielectric permittivity. At large $\zeta $ , when $\alpha \not = 0$ , the electro-osmotic mobility is found to be proportional to $\zeta / 2$ , in contrast to $\zeta $ as predicted by the standard PNP model. This is attributed to ion saturation at large $\zeta $ . In terms of the electrophoretic mobility ${M}_{e} $ , we carry out both an asymptotic analysis in the thin-double-layer limit and solve the full modified PNP model to compute ${M}_{e} $ . Our analysis reveals that the impact of the dielectric decrement is intriguing. At small and moderate $\zeta ~({\lt }6kT/ e)$ , the dielectric decrement decreases ${M}_{e} $ with increasing $\alpha $ . At large $\zeta $ , it is known that the surface conduction becomes significant and plays an important role in determining ${M}_{e} $ . It is observed that the dielectric decrement effectively reduces the surface conduction. Hence in stark contrast, ${M}_{e} $ increases as $\alpha $ increases. Our predictions of the contrast dependence of the mobility on $\alpha $ at different zeta potentials qualitatively agree with experimental results on the dependence of the mobility among ions and provide a possible explanation for such ion specificity. Finally, the comparisons between the thin-double-layer asymptotic analysis and the full simulations of the modified PNP model suggest that at large $\zeta $ the validity of the thin-double-layer approximation is determined by ${l}_{c} $ rather than the traditional Debye length.