Miracle-dz/UniFAR-FTUs huggingface dataset:
Chitosan-Based In Situ Gels for Ocular Delivery of Therapeutics: A State-of-the-Art Review

Ocular in situ gels are a promising alternative to overcome drawbacks of conventional eye drops because they associate the advantages of solutions such as accuracy and reproducibility of dosing, or ease of administration with prolonged contact time of ointments. Chitosan is a natural polymer suitable for use in ophthalmic formulations due to its biocompatibility, biodegradability, mucoadhesive character, antibacterial and antifungal properties, permeation enhancement and corneal wound healing effects. The combination of chitosan, pH-sensitive polymer, with other stimuli-responsive polymers leads to increased mechanical strength of formulations and an improved therapeutic effect due to prolonged ocular contact time. This review describes in situ gelling systems resulting from the association of chitosan with various stimuli-responsive polymers with emphasis on the mechanism of gel formation and application in ophthalmology. It also comprises the main techniques for evaluation of chitosan in situ gels, along with requirements of safety and ocular tolerability.
Association of Pre-onset Subthreshold Psychotic Symptoms With Longitudinal Outcomes During Treatment of a First Episode of Psychosis

Importance The clinical high-risk state in psychosis is most often characterized by subthreshold psychotic symptoms (STPS) and represents a target for psychosis prevention. However, evidence suggests that between 30% and 50% of patients with a first episode of psychosis (FEP) report no prior history of STPS, indicating that not all patients with FEP experience a previous clinical high-risk phase. As with other early characteristics of illness onset, this diversity in the early course of symptoms may offer prognostic value for subsequent clinical trajectories. Objective To determine whether a history of pre-onset STPS is associated with differential 1-year treatment outcomes in an early intervention service for FEP. Design, Setting, and Participants Data on 195 patients 15 to 35 years of age who were recruited between January 17, 2003, and October 17, 2013, were collected from a catchment-based specialized early intervention service for FEP. Patients who reported experiencing at least 1 STPS prior to the onset of FEP were identified as STPS present (STPSp; n = 135); those who reported no such history were identified as STPS absent (STPSa; n = 60). Statistical analysis was conducted from December 15, 2016, to February 15, 2018. Main Outcomes and Measures Summary scores on the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms, Calgary Depression Scale for Schizophrenia, Hamilton Anxiety Rating Scale, Global Assessment of Functioning scores, and Social and Occupational Functioning Assessment Scale scores at baseline and after 1 year of treatment were analyzed to evaluate 1-year outcomes. Results Individuals in the STPSp group (39 female and 96 male participants; mean [SD] age, 23.4 [4.2] years) and the STPSa group (20 female and 40 male participants; mean [SD] age, 23.9 [5.1] years) did not differ in symptom severity or functioning at baseline. Although both groups improved by 1 year of treatment, mixed analyses of covariance (controlling for duration of untreated psychosis) revealed group-by-time interactions for scores on the Scale for the Assessment of Negative Symptoms (F1,192 = 6.17; P = .01), the Global Assessment of Functioning (F1,188 = 7.54; P = .006), and the Social and Occupational Functioning Assessment Scale (F1,192 = 3.79; P = .05). Mixed analyses of covariance also revealed a group effect for scores on the Scale for the Assessment of Positive Symptoms (F1,192 = 5.31; P = .02). After controlling for multiple comparisons, all significant results indicate poorer 1-year outcomes for patients with STPSp compared with patients with STPSa. Conclusions and Relevance A history of pre-onset STPS consistent with a prior clinical high-risk state is associated with poorer outcomes in psychotic symptoms and global functioning for patients after 1 year of treatment for FEP. The presence or absence of pre-onset STPS therefore has prognostic value for treatment outcomes, even during a later stage of psychotic illness.
Reconstructive aspects: Summary and consensus statements of group 3. The 5th EAO Consensus Conference 2018.

OBJECTIVES The tasks of this working group were to evaluate the existing evidence on the efficiency and efficacy of the digital and conventional workflows for the fabrication of fixed implant reconstructions, to assess the performance of all-ceramic fixed implant reconstructions and, finally, to evaluate the outcomes of internally and externally connected implant abutments and reconstructions. METHODS Four reviews were available analyzing the current literature on the respective topics. One review dealt with the efficiency and efficacy of digital and conventional fabrication workflows. Two reviews analyzed the outcomes of all-ceramic fixed implant reconstructions, one focusing on single-implant reconstructions and the other evaluating multiple-unit implant fixed dental prostheses (FDPs). The fourth review evaluated the clinical outcome on external, respectively, internal implant-abutment connections. These reviews were the basis for the discussions within the group and at the plenary sessions. RESULTS The present consensus report gives the consensus statements, the clinical recommendations, and the implications for future research as discussed and approved by the plenum of the consensus conference. The four manuscripts by Mühlemann et al., Rabel et al., Pieralli et al., and Pjetursson et al. are published as part of the journal supplement of the present EAO consensus conference.
Clinical Proteomics for Post‐Hematopoeitic Stem Cell Transplantation Outcomes

Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective form of tumor immunotherapy available to date. However, while HSCT can induce beneficial graft‐versus‐leukemia (GVL) effect, the adverse effect of graft‐versus‐host disease (GVHD), which is closely linked to GVL, is the major source of morbidity and mortality following HSCT. Until recently, available diagnostic and staging tools frequently fail to identify those at higher risk of disease progression or death. Furthermore, there are shortcomings in the prediction of the need for therapeutic interventions or the response rates to different forms of therapy. The past decade has been characterized by an explosive evolution of proteomics technologies, largely due to important advances in high‐throughput MS instruments and bioinformatics. Building on these opportunities, blood biomarkers have been identified and validated both as promising diagnostic tools, prognostic tools that risk‐stratify patients before future occurrence of GVHD and as predictive tools for responsiveness to GVHD therapy and non‐relapse mortality. These biomarkers might facilitate timely and selective therapeutic intervention. This review summarizes current information on clinical proteomics for GVHD as well as other complications following HSCT. Finally, it proposes future directions for the translation of clinical proteomics to discovery of new potential therapeutic targets to the development of drugs.
A Long-Cycle-Life Self-Doped Polyaniline Cathode for Rechargeable Aqueous Zinc Batteries.

Rechargeable aqueous zinc batteries are promising energy-storage systems for grid applications. Highly conductive polyaniline (PANI) is a potential cathode, but it tends to deactivate in electrolytes with low acidity (i.e. pH >1) owing to deprotonation of the polymer. In this study, we synthesized a sulfo-self-doped PANI electrode by a facile electrochemical copolymerization process. The -SO3 - self-dopant functions as an internal proton reservoir to ensure a highly acidic local environment and facilitate the redox process in the weakly acidic ZnSO4 electrolyte. In a full zinc cell, the self-doped PANI cathode provided a high capacity of 180 mAh g-1 , excellent rate performance of 70 % capacity retention with a 50-fold current-density increase, and a long cycle life of over 2000 cycles with coulombic efficiency close to 100 %. Our study opens a door for the use of conducting polymers as cathode materials for high-performance rechargeable zinc batteries.
Radon transform of auditory neurograms: a robust feature set for phoneme classification

Classification of speech phonemes is challenging, especially under noisy environments, and hence traditional speech recognition systems do not perform well in the presence of noise. Unlike traditional methods in which features are mostly extracted from the properties of the acoustic signal, this study proposes a new feature for phoneme classification using neural responses from a physiologically based computational model of the auditory periphery. The two-dimensional neurogram was constructed from the simulated responses of auditory-nerve fibres to speech phonemes. Features of neurogram images were extracted using the Discrete Radon Transform, and the dimensionality of features was reduced using an efficient feature selection technique. A standard classifier, Support Vector Machine, was employed to model and test the phoneme classes. Classification performance was evaluated in quiet and under noisy conditions in which test data were corrupted with various environmental distortions such as additive noise, room reverberation, and telephone-channel noise. Performances were also compared with the results from existing methods such as the Mel-frequency cepstral coefficient, Gammatone frequency cepstral coefficient, and frequency-domain linear prediction-based phoneme classification methods. In general, the proposed neural feature exhibited a better classification accuracy in quiet and under noisy conditions compared with the performance of most existing acoustic-signal-based methods.
EZH2-Mediated microRNA-139-5p Regulates Epithelial-Mesenchymal Transition and Lymph Node Metastasis of Pancreatic Cancer

Pancreatic cancer (PC) is one of the most aggressive cancers presenting with high rates of invasion and metastasis, and unfavorable prognoses. The current study aims to investigate whether EZH2/miR-139-5p axis affects epithelial-mesenchymal transition (EMT) and lymph node metastasis (LNM) in PC, and the mechanism how EZH2 regulates miR-139-5p. Human PC and adjacent normal tissues were collected to determine expression of EZH2 and miR-139-5p, and their relationship with clinicopathological features of PC. Human PC cell line was selected, and treated with miR-139-5p mimics/inhibitors, EZH2 vector or shEZH2 in order to validate the regulation of EZH2-mediated miR-139-5p in PC cells. Dual-luciferase report gene assay and chromatin immunoprecipitation assay were employed to identify the relationship between miR-139-5p and EZH2. RT-qPCR and Western blot analysis were conducted to determine the expression of miR-139-5p, EZH2 and EMT-related markers and ZEB1/2. Tumor formation ability and in vitro cell activity were also analyzed. Highly-expressed EZH2 and poorly-expressed miR-139-5p were detected in PC tissues, and miR-139-5p and EZH2 expressions were associated with patients at Stage III/IV, with LNM and highly-differentiated tumors. EZH2 suppressed the expression of miR-139-5p through up-regulating Histone 3 Lysine 27 Trimethylation (H3K27me3). EMT, cell proliferation, migration and invasion were impeded, and tumor formation and LNM were reduced in PC cells transfected with miR-139-5p mimics and shEZH2. MiR-139-5p transcription is inhibited by EZH2 through up-regulating H3K27me3, thereby down-regulation of EZH2 and up-regulation of miR-139-5p impede EMT and LNM in PC. In addition, the EZH2/miR-139-5p axis presents as a promising therapeutic strategy for the treatment of PC.
On Variety, Complexity, and Engagement in Crowdsourced Disaster Response Tasks

Crowdsourcing is used to enlist workers as a resource for a variety of applications, including disaster response. However, simple tasks such as image labeling often feel monotonous and lead to worker disengagement. This provides a challenge for designing successful crowdsourcing systems. Existing research in the design of work indicates that task variety is a key factor in worker motivation. Therefore, we asked Amazon Mechanical Turk workers to complete a series of disaster response related subtasks, consisting of either image labeling or locating photographed areas on a map. We varied the frequency at which workers encountered the different subtask types, and found that switching subtask type at different frequencies impacted measures of worker engagement. This indicates that a certain amount of variety in subtasks may engage crowdsourcing workers better than uniform subtask types.
Transcranial Direct Current Stimulation Improves Semantic Speech–Gesture Matching in Patients With Schizophrenia Spectrum Disorder

Abstract Background Patients with schizophrenia spectrum disorders (SSD) have severe deficits in speech and gesture processing that contribute considerably to the burden of this disorder. Brain imaging shows left inferior frontal gyrus involvement for impaired processing of co-verbal gestures in patients with schizophrenia. Recently, transcranial direct current stimulation (tDCS) of the left frontal lobe has been shown to modulate processing of co-verbal gestures in healthy subjects. Although tDCS has been used to reduce symptoms of patients with SSD, the effects of tDCS on gesture processing deficits remain hitherto unexplored. Objective Here we tested the hypothesis that inhibitory cathodal tDCS of the left frontal lobe decreases pathological dysfunction and improves semantic processing of co-verbal gestures in patients with SSD. Methods We measured ratings and reaction times in a speech–gesture semantic relatedness assessment task during application of frontal, frontoparietal, parietal, and sham tDCS to 20 patients with SSD and 29 healthy controls. Results We found a specific effect of tDCS on speech–gesture relatedness ratings of patients. Frontal compared to parietal and sham stimulation significantly improved the differentiation between related and unrelated gestures. Placement of the second electrode (right frontal vs parietal) did not affect the effect of left frontal stimulation, which reduced the preexisting difference between patients and healthy controls. Conclusion Here we show that left frontal tDCS can improve semantic co-verbal gesture processing in patients with SSD. tDCS could be a viable tool to normalize processing in the left frontal lobe and facilitate direct social communicative functioning in patients with SSD.
Carbon price volatility: The case of China

Based on carbon spot prices selected from seven carbon pilots, we assess the financial performances related to carbon volatility in China on the overall perspective. According to the results, the Chinese carbon market fluctuated severely at the beginning of carbon trading, but has stabilised in general, despite several dramatic changes related to ‘yearly compliance events’. Long-term memory exists in the volatility series. Moreover, asymmetry exists in the Chinese carbon market, and volatility reacts more severely to good news than to bad news. Finally, we discuss our empirical results, and make certain suggestions regarding firms’ awareness, international cooperation and individual investors not only for policy makers in China but also for other developing countries who are contemplating either commencing carbon trading or improving the current market.
Strategies to reduce sugar-sweetened beverage consumption and increase water access and intake among young children: perspectives from expert stakeholders

Abstract Objectives To summarize stakeholder recommendations and ratings of strategies to reduce sugar-sweetened beverage (SSB) consumption and increase water access and intake among young children (0–5 years). Design Two online surveys: survey 1 asked respondents to recommend novel and innovative strategies to promote healthy beverage behaviour; survey 2 asked respondents to rank each of these strategies on five domains (overall importance, feasibility, effectiveness, reach, health equity). Open-ended questions were coded and analysed for thematic content. Setting Using a snowball sampling approach, respondents were invited to complete the survey through an email invitation or an anonymous listserv link. Of the individuals who received a private email invitation, 24 % completed survey 1 and 29 % completed survey 2. Subjects Survey 1 (n 276) and survey 2 (n 182) included expert stakeholders who work on issues related to SSB and water consumption. Results Six overarching strategies emerged to change beverage consumption behaviours (survey 1): education; campaigns and contests; marketing and advertising; price changes; physical access; and improving the capacity of settings to promote healthy beverages. Labelling and sugar reduction (e.g. reformulation) were recommended as strategies to reduce SSB consumption, while water testing and remediation emerged as a strategy to promote water intake. Stakeholders most frequently recommended (survey 1) and provided higher ratings (survey 2) to strategies that used policy, systems and/or environmental changes. Conclusions The present study is the first to assess stakeholder opinions on strategies to promote healthy beverage consumption. This knowledge is key for understanding where stakeholders believe resources can be best utilized.
Agreement between Graz Malnutrition Screening (GMS) with subjective nutritional assessment instruments in hospitalized patients.

BACKGROUND it is essential for an early nutritional intervention that utilizes effective and practical nutritional screening and evaluation tools to diagnose nutritional status, increasing the patient's survival. OBJECTIVE to evaluate the agreement of the Graz Malnutrition Screening (GMS) with subjective methods of nutritional evaluation in hospitalized patients. METHODS descriptive cross-sectional study with adults and elderly of both sexes evaluated within 48 hours of hospital admission. Nutritional status in cancer patients was identified by the Patient-Generated Subjective Global Assessment (PG-SGA®) and in the elderly by the Mini Nutritional Assessment Short-Form (MNA-SF®). GMS was applied in both groups and its efficiency was compared with that of PG-SGA® and MNA-SF®. The agreement between the methods was evaluated by the kappa test, followed by assessment of diagnostic performance and correlation test. RESULTS: of the 87 patients evaluated, 64.4% (56) presented nutritional risk according to GMS, while 49.4% (43) and 47.1% (41) indicated nutritional risk and malnutrition according to MNA-SF® and PG-SGA®, respectively. GMS presented moderate agreement with PG-SGA®(p < 0.001) and MNA-SF® (p < 0.001), with high sensitivity, specificity, positive predictive value, and negative predictive value. Correlations wereobserved between the GMS score and both the PG-SGA® (p < 0.001) and MNA-SF® scores (p < 0.001). CONCLUSION GMS was effective in detecting nutritional risk in hospitalized patients when compared to classic tools in the evaluation of nutritionalstatus in hospitalized patients.
Detection of Sensor Attack and Resilient State Estimation for Uniformly Observable Nonlinear Systems having Redundant Sensors

This paper presents a detection algorithm for sensor attacks and a resilient state estimation scheme for a class of uniformly observable nonlinear systems. An adversary is supposed to corrupt a subset of sensors with the possibly unbounded signals, while the system has sensor redundancy. We design an individual high-gain observer for each measurement output so that only the observable portion of the system state is obtained. Then, a nonlinear error correcting problem is solved by collecting all the information from those partial observers and exploiting redundancy. A computationally efficient, on-line monitoring scheme is presented for attack detection. Based on the attack detection scheme, an algorithm for resilient state estimation is provided. The simulation results demonstrate the effectiveness of the proposed algorithm.
Geometric means and medians with applications to target detection

This study explores the application of geometric measures-based means and medians on the Riemannian manifold of Hermitian positive-definite (HPD) matrix to target detection problems in radar systems. Firstly, the slow-time dimension of radar received clutter data in each cell is modelled and mapped to HPD matrix space, which can be described as a complex Riemannian manifold. Each point of this manifold is an HPD matrix. Then, several geometric measures are presented for measuring closeness between two HPD matrices. According to these measures, the means and medians of a finite collection of HPD matrices are deduced, and various matrix constant false alarm rate (CFAR) detectors are designed. The principle of target detection is that if a location has enough dissimilarity from the geometric mean or median estimated by its neighbouring locations, targets are supposed to appear at this location. Moreover, different distance measures adopted in detector can result in different performance of detection. These differences are owing to different measure structure, reflected by the anisotropy of a location on the Riemannian manifold. Numerical experiments are given to demonstrate the relationship between anisotropy of the geometric measures and the detection performance of their corresponding matrix CFAR detectors.
Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1

Colonic epithelial cells are highly polarised with a lumen‐facing apical membrane, termed the brush border, and a basal membrane in contact with the underlying extracellular matrix (ECM). This polarity is often maintained in cancer tissue in the form of neoplastic glands and has prognostic value. We compared the cellular polarity of several ex vivo spheroid colonic cancer cultures with their parental tumours and found that those grown as non‐attached colonies exhibited apical brush border proteins on their outer cellular membranes. Transfer of these cultures to an ECM, such as collagen, re‐established the centralised apical polarity observed in vivo. The multidrug resistance protein ABCB1 also became aberrantly polarised to outer colony membranes in suspension cultures, unlike cultures grown in collagen, where it was polarised to central lumens. This polarity switch was dependent on the presence of serum or selected serum components, including epidermal growth factor (EGF), transforming growth factor‐β1 (TGF‐β1) and insulin‐like growth factor‐1 (IGF‐1). The apical/basal orientation of primary cancer colon cultures cultured in collagen/serum was modulated by α2β1 integrin signalling. The polarisation of ABCB1 in colonies significantly altered drug uptake and sensitivity, as the outward polarisation of ABCB1 in suspension colonies effluxed substrates more effectively than ECM‐grown colonies with ABCB1 polarised to central lumens. Thus, serum‐free suspension colonies were more resistant to a variety of anti‐cancer drugs than ECM‐grown colonies. In conclusion, the local stroma, or absence thereof, can have profound effects on the sensitivity of colorectal cultures to drugs that are ABCB1 substrates. © 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.