Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Radical Prostatectomy Capsular Margins of Resection: The Significance of Margins Designated as Negative, Closely Approaching, and Positive

Capsular margins of resection in radical prostatectomy specimens performed for carcinoma of the prostate are difficult to assess because of the scant soft tissue removed with the prostate. There is little objective information as to the validity of what are designated as positive or negative capsular margins of resection. From January 1, 1984 through June 30, 1989 there were 40 radical prostatectomies performed in which the prostate was initially removed leaving the neurovascular bundle within the patient in order to preserve potency. However, based on the surgeons' gross examination of the prostate at the time of radical prostatectomy, the neurovascular bundle was then subsequently removed during the same operation and submitted to pathology as a separate specimen. In these 40 cases the capsular margin in the region of the neurovascular bundle was assessed blindly without knowledge of tumor presence or absence in the subsequently resected neurovascular bundle, and then compared to whether the neurovascular bundle contained tumor. Of the 10 cases called positive based on review of the radical prostatectomy, only six neurovascular bundles (60%) contained tumor. Eight cases had equivocal margins with tumor extending just to the inked margin, and only one (12.5%) had tumor in the neurovascular bundle. All 20 cases with negative assigned margins had complete removal of tumor from this area with none of the neurovascular bundles containing tumor. This study demonstrated that negative capsular margins in radical prostatectomy specimens often contain only a scant amount of soft tissue. Of the 33 cases with true negative margins, the amount of soft tissue between the inked margin and tumor was only >1 mm in two cases and ⩽1 m in 20 cases (<0.5 mm in 13 cases with <0.25 mm in eight of these cases). Furthermore, 11 cases with tumor extending to the inked margin of resection showed no residual tumor in additional tissue removed from these regions.
MeHarCEn: Um Método de Harmonização do Consumo de Energia em Data Centers

O consumo energetico controlado e eficiente e um desafio enfrentado diariamente pelos gestores de Data Centers de pequeno, medio e grande porte. A literatura especializada e tecnica define diversos guias, equipamentos e mecanismos para essa finalidade. Entretanto, a aplicacao combinada dessas solucoes e uma tarefa complexa, que, em muitos casos, requer um elevado investimento financeiro. Nesse contexto, o presente trabalho propoe o MeHarCEn, uma iniciativa para gerenciamento combinado e harmonico do consumo de energia em Data Centers. MeHarCEn nao depende de solucoes proprietarias e pode ser adaptado a Data Centers com configuracoes distintas. Aplicado a um estudo de caso, um DC de pequeno porte, o MeHarCEn resulta em uma economia de 52,7% no consumo de energia com climatizacao.
Distributed and Memory Efficient Machine Learning for Spatial Analysis Applications

In the context of spatial analysis, spatial disaggregation or spatial downscaling are processes by which information at a coarse spatial scale is translated to finer scales, while maintaining consistency with the original dataset. Fine grained descriptions of geographical information is a key resource in fields such as social-economic studies, urban and regional planning, transport planning, or environment impact analysis. However, spatial disaggregation involves heavily iterative, and computational demanding algorithms, seriously compromising performance when the data sets at play involve large geospatial regions and contains large volumes of information. This paper presents a M.Sc. thesis project that concerns with the development of a scalable and efficient approach to spatial disaggregation, taking advantage of state-of-art approaches for parallel and distributed computation, as well as methods for leveraging
Bandwidth improvement of multilayer common mode filter by time domain method

In demand of high-speed differential data communication, the common mode filter is usually presented. The new common mode filter demonstrated in this paper is designed by edge-coupled differential pairs. By using double loops routing structure, the coupling inductance is increased. To achieve sufficient common mode noise suppression while introducing minimal signal insertion loss, the full-wave time domain EM simulator is applied.
A reply

References 1. Niraj G, Kelkar A, Hart E, et al. Comparison of analgesic efficacy of four-quadrant transversus abdominis plane (TAP) block and continuous posterior TAP analgesia with epidural analgesia in patients undergoing laparoscopic colorectal surgery: an open-label, randomised, noninferiority trial. Anaesthesia 2014; 69: 348–55. 2. Niraj G, Kelkar A, Jeyapalan I, et al. Comparison of analgesic efficacy of subcostal transversus abdominis plane blocks with epidural analgesia following upper abdominal surgery. Anaesthesia 2011; 66: 465–71. 3. Rao Kadam V, Van Wijk RM, Moran JI, Miller D. Epidural versus continuous transversus abdominis plane catheter technique for postoperative analgesia after abdominal surgery. Anaesthesia and Intensive Care 2013; 41: 476–81. 4. Wu Y, Liu F, Tang H, et al. The analgesic efficacy of subcostal transversus abdominis plane block compared with thoracic epidural analgesia and intravenous opioid analgesia after radical gastrectomy. Anesthesia and Analgesia 2013; 117: 507–13. 5. Kim SH, Na S, Choi JS, Na SH, Shin S, Koh SO. An evaluation of diaphragmatic movement by M-mode sonography as a predictor of pulmonary dysfunction after upper abdominal surgery. Anesthesia and Analgesia 2010; 110: 1349–54.
Arc fault detection based on temporal analysis

This article describes arc faults detection methods based on the temporal analysis of electric lines current signatures. We first give the, specifications of the domestic loads under test. Then, we describe the methods under test: crest factor, average value, variance, adaptive filter and mathematics moments. In the second part, these methods are implemented on MATLAB - Simulink. The analysis is done on the current for each period half cycle. The ability of arc faults detection is then presented for each algorithm.
Missing value estimation for DNA microarray gene expression data with principal curves

Computing analysis of gene expression data has been an essential approach for understanding cellular activities and identifying gene function. However, expression profiles generated by the high-throughput microarray experiments often contain missing values, which significantly affect the performance of subsequent statistical analysis and machine learning algorithms. So there is a great need for estimating these missing values as accurately as possible. Although there have been many estimation algorithms, but each of them has its flaws. This paper proposes an estimation method for missing values based on principal curve which is a nonlinear generalization of the first linear principal component analysis. Through finding the self-consistent smooth one dimensional curves that pass through the ‘middle’ of a multidimensional data set, principal curve can integrate the linear and nonlinear relationships between genes, and reveal the distribution of genes. Based on the framework of all the expression profiles, missing values can be estimated more accurately. To assess the performance of the method, comparisons with recently proposed estimation algorithms are carried out on several microarray data sets. The results shows that our method provides a better solution for the estimation of missing values in DNA microarray gene expression data.
EVOLUTION OF SOCIAL DEVELOPER NETWORK IN OSS: SURVEY

Social Developer Networks are built of complex hierarchical social network which forms relationship information between software entities. Recent research trends suggested many different successful methods on Social Developer Network to analyze its growth and advancement of network structure. Aim is to present brief survey on the analysis, method, algorithm used in developer social network and techniques and technologies available to analyze performance of the developers associated network. Further discuss the growth, extension of its research field, existing methodologies and approach, extended tasks and techniques in developer social network and OSS.
A BEM-based algorithm for soft-in soft-output detection of co-channel signals

In this paper, a soft-in soft-out multiuser detector for synchronous co-channel signals transmitted over frequency-flat Rayleigh-fading channels is described. The derivation of the proposed algorithm is based on a generalization of the expectation-maximization (EM) algorithm, called Bayesian EM. Performance results for both uncoded and coded phase shift keying transmissions show the efficacy of the proposed multiuser detection technique over slowly time-varying fading channels in a two-user system.
Polypharmacy in older oncology patients and the need for an interdisciplinary approach to side‐effect management 1

Background and objective: Older oncology patients with multiple comorbidities are at risk for adverse drug events associated with polypharmacy and drug–drug interactions due to patients’ altered pharmacokinetic/pharmacodynamic status and the narrow therapeutic windows associated with anti‐neoplastic agents. This study addresses the issue of polypharmacy and potential drug–drug interactions in outpatients in a community setting in the USA, and the prescribing behaviour of oncologists after being made aware of potential drug–drug interactions.
Requirement of B2-Type Cyclin-Dependent Kinases for Meristem Integrity in Arabidopsis thaliana[W][OA]

To maintain proper meristem function, cell division and differentiation must be coordinately regulated in distinct subdomains of the meristem. Although a number of regulators necessary for the correct organization of the shoot apical meristem (SAM) have been identified, it is still largely unknown how their function is integrated with the cell cycle machinery to translate domain identity into correct cellular behavior. We show here that the cyclin-dependent kinases CDKB2;1 and CDKB2;2 are required both for normal cell cycle progression and for meristem organization. Consistently, the CDKB2 genes are highly expressed in the SAM in a cell cycle–dependent fashion, and disruption of CDKB2 function leads to severe meristematic defects. In addition, strong alterations in hormone signaling both at the level of active hormones and with respect to transcriptional and physiological outputs were observed in plants with disturbed CDKB2 activity.
The relationship of life stressors and maternal depression to pediatric asthma morbidity in a subspecialty practice.

OBJECTIVE To examine the relationships among demographic characteristics, caregiver life stressors, and depressive symptoms of mothers and their children's asthma morbidity. SETTING Three pediatric asthma subspecialty programs, 2 in the inner city and 1 in the suburbs. DESIGN Cross-sectional census sample of caregivers of children with asthma: interviews mostly with mothers (N = 123) regarding their children's asthma symptoms and health care utilization. Information collected on demographics and caregivers' own recent life stressors and depressive symptoms. SUBJECTS Caregivers of children ages 18 months to 12 years with asthma at their subspecialty visit. MEASURES Structured interviews: a survey instrument prepared for this study and standardized instruments for depression (Center for Epidemiologic Studies--Depression) and life stressors (Crisis in Family Systems). RESULTS A total of 32% of respondents' children had high asthma morbidity, 28% intermediate, and 40% low. Caregiver life stressors and depression and the children's sex showed the strongest relationships to asthma morbidity in a model that also included race, residence, and Medicaid status. Children were more likely to have high morbidity if they had caregivers with more depressive symptoms and negative life stressors and if they were female. CONCLUSIONS Respondents experienced many life stressors and symptoms of depression while managing their children's illness. Caregivers' lives may affect their children's asthma morbidity, offering empirical evidence for the potential value of targeted case management for children in subspecialty care.
Evidence for an early G1 ionic event necessary for cell cycle progression and survival in the MCF‐7 human breast carcinoma cell line

The mechanism of the G0/G1 arrest and inhibition of proliferation by quinidine, a potassium channel blocker, was investigated in a tissue culture cell line, MCF‐7, derived from a human breast carcinoma. The earliest measurable effect of quinidine on the cell cycle was a decrease in the fraction of cells in S phase at 12 hr, followed by the accumulation of cells in G1/G0 phases at 30 hr. Arrest and release of the cell cycle established quinidine as a cell synchronization agent, with a site of arrest in early G1 preceding the lovastatin G1 arrest site by 5–6 hr. There was a close correspondence among the concentration‐dependent arrest by quinidine in G1, depolarization of the membrane potential, and the inhibition of ATP‐sensitive potassium currents, supporting a model in which hyperpolarization of the membrane potential and progression through G1 are functionally linked. Furthermore, the G1 arrest by quinidine was overcome by valinomycin, a potassium ionophore that hyperpolarized the membrane potential in the presence of quinidine. With sustained exposure of MCF‐7 cells to quinidine, expression of the Ki67 antigen, a marker for cells in cycle, decreased, and apoptotic and necrotic cell death ensued. We conclude that MCF‐7 cells that fail to progress through the quinidine‐arrest site in G1 die. J. Cell. Physiol. 176:456‐464, 1998. © 1998 Wiley‐Liss, Inc.
The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function

SUMMARY Muscle LIM protein (MLP) is a cytoskeletal protein located at the Z-disc of sarcomeres. Mutations in the human MLP gene are associated with hypertrophic and dilated cardiomyopathy. MLP has been proposed to be a key player in the stretch-sensing response, but the molecular mechanisms underlying its function in normal and diseased cardiac muscle have not been established. A Drosophila homolog, Mlp84B, displays a similar subcellular localization at the Z-disc of sarcomeres throughout development and in the adult, suggesting Drosophila as a model to study MLP function. Here we employed genetic ablation and cardiac-specific RNA interference (RNAi) knockdown of mlp84B to investigate its role in heart function. We found that Mlp84B-deficient or heart-specific RNAi knockdown flies exhibit diastolic interval prolongation, heart rhythm abnormalities and a reduced lifespan, while showing no obvious structural phenotype. Our data demonstrate that Mlp84B is essential for normal cardiac function and establish the Drosophila model for the investigation of the mechanisms connecting defective cardiac Z-disc components to the development of cardiomyopathy.
Ontology-Based Privacy Protection in Location Commerce

Location commerce extends e-commerce through the provision of location-related activities, but this gives rise to greater concerns about privacy invasion. To encourage the smooth growth of location commerce, it is suggested that control over the sharing of intimate information be given back to the consumer. This study proposes an ontology-based privacy protection (OPP) framework that allows consumers to specify their own privacy preferences and then uses these preferences to determine whether or not a message from a merchant can be delivered to a consumer. We use ontology to structure the knowledge to simplify the framework and allow for the possibility of automation. The system is believed to be context-aware, as the location, time, service type, information type, and other contextual data are taken into consideration. We develop a prototype system for demonstration and experiment, and show that the framework design is feasible and has a reasonable performance.
Nutrition, Fruits and Vegetable Intake and Lipid Profile of Obese and Non-Obese Schoolchildren in Bandar Lampung Indonesia: A Cross-Sectional Study

Objectives: There is currently no data on the prevalence of obesity and li-pid profile as well as nutrition and food intake of elementary schoolchildren in Bandar Lampung city. Therefore, the aim of this study was to investigate obesity prevalence and dyslipidemia in children. Design, setting, and participants: Cross-sectional study on grade 4 school children in Bandar Lampung Indonesia (n = 392). Outcome measures: Characteristics of schoolchildren and their family, nutrition, fruits, and vegetable intakes, and physical activities, body mass index (BMI) and lipid profile were collected from 392 children of grade 4 from five elementary schools in Bandar Lampung. One-way ANOVA and correlation analysis were applied with BMI and lipid profiles as dependent variables. Results: The incidence of undernutrition (7.7%) was lower than the incidence of overnutrition (26.3%). Energy, protein and fat daily intake were higher for children with higher BMI, however, carbohydrate consumption was not affecting the BMI. Obese children had more vegetable and fruit intake than wasting children and spent 30 minutes less in physical activity than normal children. Lipid plasma of schoolchildren was considered as acceptable or borderline high except for the TG of obese children in the high category. Conclusions: Prevalence of obesity was high and being obese was more likely to result in higher TG and lower HDL. The lifestyle of obese schoolchildren was characterized by a high intake of energy, protein, and fat and lower physical activities. Encouraging schoolchildren to modify their lifestyles is recommended.
Conservation of plant genetic resources by cryopreservation.

Cryopreservation is a perfect method for long-term conservation of plant genetic resources, using very low temperature (liquid nitrogen, -196 C). This method has been recognized as a practical and efficient tool for the long-term storage of germplasm. Cryopreservation methods may provide the conditions for unlimited conservation of biological materials by reducing metabolic rates. During the cryopreservation all biochemical activities significantly reduced and biological deterioration are stopped. Conservation and subsequent sustainable use of genetic resources are essential to meet the demand for future food security. Several techniques have been developed yet to minimize the damaging effects of desiccation and freezing, ensuring high recovery of plant materials. Cellular division of germplasm is normally repressed after exposure to LN. In addition, metabolic and most physical processes are stopped at this temperature. Thus, plants can be stored for very long time and the problems such as genetic instability and the risk of loose accessions due to contamination or human error during subculture overcome. Techniques like cryopreservation collect and conserve plant genetic resources, especially plants with limited seed storage capability. There is only limited number of plants that cryopreservation techniques are used for their germplasm conservation, mainly because the techniques need to be adapted for each species. Therefore, continued efforts are needed in cryopreservation techniques to develop protocols for a wider range of plants. Formation of ice crystal during cryopreservation is detrimental to cellular structure integrity and causes physical damage to the cells. Air-drying, freeze dehydration, osmotic dehydration, addition of penetrating and non-penetrating cryoprotective substances, and hardening metabolism or combinations of these processes are cryogenic strategies. Nowadays, conservation of plant germplasm has altered from slow cooling to vitrification. However, the availability or developments of simple, reliable and cost-effective strategies and the subsequent regeneration of the plants are basic requirements for germplasm conservation.
Expression of immune-related molecules in primary EBV positive chinese nasopharyngeal carcinoma: Associated with latent membrane protein 1 (LMP1) expression

To understand the role of Epstein-Barr virus (EBV) and viral products in associated with immunophenotype and clinical outcome of primary nasopharyngeal carcinoma (NPC), the expression levels of chemokines IFN-γ-induced protein 10 (IP-10, CXCL10), stromal-derived factor-1 (SDF-1, CXCL12) and its receptor CXCR4 was investigated in 56 primary NPC biopsy specimens from Chinese NPC patients in parallels with LMP1 antigen and EBER1 by immunohistochemisty (IHC) and in situ hybridization (ISH). Moreover, the expression levels of HLA class I (β-microglobulin) and II antigen (HLA-DR), and co-stimulatory molecule CD54 were also evaluated in 31 out of these 56 patients using immunohistochemisty (IHC). Our results showed that (a) the elevated expression levels of IP10, SDF-1, CXCR4, β-microglobulin, HLA-DR, and CD54 in NPC lesions was 66%, 36%, 30%, 42%, 55% and 69%, respectively. (b) High expression of SDF-1 was observed in advanced NPC (N stage, P
Thermodynamic properties of small magnetic particles

We investigate the equilibrium magnetic properties of a simple cubic small ferromagnetic particle under an external magnetic field. Although the particle is small, it can not be considered as a single-domain unit. The magnetic moments are represented by unitary spin vectors and we consider ferromagnetic interactions between nearest-neighbor spins. The coupling between spins is given in terms of the classical Heisenberg Hamiltonian and we also include a Zeeman contribution and a single-ion uniaxial anisotropy. The size of the particle changes from one to twelve lattice spacings. We employ in our study mean-filed calculations and Monte Carlo simulations. The magnetization and susceptibility curves as a function of temperature show that an uniaxial anisotropy can mimic a ferromagnetic or an antiferromagnetic coupling, depending on the angle between the external magnetic field and the easy axis.
Realistic simulation of vehicular communication and vehicle-2-X applications

In future intelligent transport systems, wireless vehicular communication will provide the basis for new applications to enhance safety, traffic efficiency, and provide infotainment services. In the near future, field tests are to be carried out to verify the improvements that could be achieved by these new Vehicle-2-X applications. However, the realisation of such field tests is very complex and expensive. Therefore, detailed simulations are necessary to prepare the tests in the real world and reduce their costs. Current simulation tools do not support all aspects necessary for Vehicle-2-X applications. In this paper, we present an integrated software simulation environment that fulfils the special requirements of Vehicle-2-X applications. Furthermore, we introduce our testbed architecture that allows simulating vehicular communication under real physical conditions.
AND ITS RELATION TO SPREAD OF ANESTHETIC SOLUTIONS IN EPIDURAL SPACE

LTHOUGH there is considerable disagreeA ment among authors as to the ultimate mode of action of epidural anesthetics, all agree that the first event after epidural injection is the spread of the anesthetic solution within the extradural space. Using ra&opaque1 and radioactive? technics, and determining the cutaneous area of anesthesia? -* many factors have been shown to influence epidural spread. Some of the variables are inherent to the patient’s physical characteristics, such as age, arteriosclerosis, pregnancy, venous circulation, and extradural fat. Others are under the direct control of the anesthesiologist, such as positioning the patient, choosing the site of epidural puncture, orientation of the needle bevel, and determining the speed of injection and volume and concentration of anesthetic solution.