Miracle-dz/UniFAR-FTUs huggingface dataset:
Multiple-Ascending-Dose Phase 1 Clinical Study of the Safety, Tolerability, and Pharmacokinetics of CRS3123, a Narrow-Spectrum Agent with Minimal Disruption of Normal Gut Microbiota

CRS3123 is a novel small molecule that potently inhibits methionyl-tRNA synthetase of Clostridioides difficile, inhibiting C. difficile toxin production and spore formation. CRS3123 has been evaluated in a multiple-ascending-dose placebo-controlled phase 1 trial. ABSTRACT CRS3123 is a novel small molecule that potently inhibits methionyl-tRNA synthetase of Clostridioides difficile, inhibiting C. difficile toxin production and spore formation. CRS3123 has been evaluated in a multiple-ascending-dose placebo-controlled phase 1 trial. Thirty healthy subjects, ages 18 to 45 years, were randomized into three cohorts of 10 subjects each, receiving either 200, 400, or 600 mg of CRS3123 (8 subjects per cohort) or placebo (2 subjects per cohort) by oral administration twice daily for 10 days. CRS3123 was generally safe and well tolerated, with no serious adverse events (SAEs) or severe treatment-emergent adverse events (TEAEs) reported. All subjects completed their assigned treatment and follow-up visits, and there were no trends in systemic, vital sign, or laboratory TEAEs. There were no QTcF interval changes or any clinically significant changes in other electrocardiogram (ECG) intervals or morphology. CRS3123 showed limited but detectable systemic uptake; although absorption increased with increasing dose, the increase was less than dose proportional. Importantly, the bulk of the oral dose was not absorbed, and fecal concentrations were substantially above the MIC90 value of 1 μg/ml at all dosages tested. Subjects receiving either of the two lower doses of CRS3123 exhibited minimal disruption of normal gut microbiota after 10 days of twice-daily dosing. CRS3123 was inactive against important commensal anaerobes, including Bacteroides, bifidobacteria, and commensal clostridia. Microbiome data showed favorable differentiation compared to other CDI therapeutics. These results support further development of CRS3123 as an oral agent for the treatment of CDI. (This study has been registered at Clinicaltrials.gov under identifier NCT02106338.)
Study of Biogas Output Increase Depending on Organic Load Conditions and Parameters

Organic load conditions and parameters on the anaerobic bioreactor operation, where comfort temperature is 35oC, were determined. A specific biogas output, fallen into 1 m3 of the bioreactor and specific biogas output, fallen into 1 kg of remote COD from the bioreactor organic load, were determined. The relationship between the rundown time and solids content based on viscosity measurement was determined. The relationship between measured rundown time and corresponding solids content in the fermenting material, as well as relationship between content of COD and organic solids in the substrate mixture were found. The relation between change in NH4N percentage in N total – N, as well as between content of organic solids in the substrate mixture and settling time of the substrate were determined. The content of organic solids in the substrate mixture and CH4 output per one ton of the clean substrate and per one ton of the organic solids was correlated.
Common-reflection-point migration velocity analysis of 2D P-wave data from TTI media

ABSTRACTWe have developed a common-reflection-point (CRP)-based kinematic migration velocity analysis for 2D P-wave reflection data to estimate the four transversely isotropic (TI) parameters VPo, δ, and e, and the tilt angle ϕ of the symmetry axis in a TI medium. In each iteration, the tomographic parameter was updated alternately with prestack anisotropic ray-based migration. Iterations initially used layer stripping to reduce the number of degrees of freedom; after convergence was reached, a couple of more iterations over all parameters and all CRPs ensured global interlayer coupling and parameter interaction. The TI symmetry axis orientation was constrained to be locally perpendicular to the reflectors. The VPo dominated the inversion, and so it was weighted less than δ and e in the parameter updates. Estimates of δ and e were influenced if the error in ϕ was >5°; estimates of VPo were also influenced if the error in ϕ was >10°. Examples included data for a simple model with a homogeneous TI layer who.
A Mobility Analysis of Using the Rhex-Type Mobile Robot in Various Surroundings

Abstract Mobile robots are becoming increasingly popular, finding a great deal of applications, especially in situations where conventional mobility systems, such as wheels or tracks, prove ineffective. Exploration of an unknown environment or a place, in which Man is incapable of staying, for example exploring remote planets in the Solar System, is often linked with operating a device in a rough terrain. This requires an adjustment of the robot locomotion system to the ground. The problem of high mobility in diverse surroundings is still a major challenge. Therefore, the concept of mobile robots is extremely popular and is still being developed. Using this type of propulsion carries several advantages, namely the possibility of applicability of this type of solutions in an environment, which is not easily accessible to wheeled vehicles (sandy, mountainous terrain, etc.). There is still a large interest of constructors and scientists in unconventional drive systems, adapted directly from nature, which often offers very efficient solutions. Quite frequently, designers copy the construction of animal locomotion system, attempting at implementing them in their designs. The aim of this article is to present an original construction, known as the Rhex-type robot in the available literature. In addition, it presents a number of conducted investigations, which describe the platform’s mobility in various terrains, such as sands, rocks and rubbles, as well as the possibility to overcome the terrain obstacles. It ends with conclusions and potential application areas of this type of a design.
Purification and Some Properties of Cyclodextrinase from Bacillus coagulans

A gram positive bacterium (strain No. 109) isolated from soil as a producer of cyclodextrinase was identified as Bacillus coagulans. The cyclodextrinase from B. coagulans was purified to a homogeneous state by disc-electrophoresis after Streptomycin treatment, DEAE-Sephadex column chromatography, Ultrogel AcA44 gel filtration and hydroxyapatite column chromatography. The molecular weight of the enzyme was determined to be 6.2}104 by sodium dodecyl-sulfate gel electrophoresis. The isoelectric point of the enzyme was pH 5.0. The enzyme was most active at pH 6.2 and 50°C, and stable up to 45°C at pH 7.0 and in the range of pH 6.0 ~ 7.3 at 40°C on 2 hr incubation. This enzyme hydrolyzed linear maltooligosaccharides (such as maltotetraose (G4), maltopentaose (G5) and maltohexaose (G6)) and α-, β- and α-cyclodextrins (CDs) faster than maltotriose (G3) and short chain amylose ( 18), but did not hydrolyze maltose. The rates of hydrolysis for polysaccharides (such as starch, amylose and amylopectin) were below 1 %.
Ozone in Preeclampsia of pregnancy. Case report

Preeclampsia is a common pregnancy disorder with important short-term complications for mother and baby. Evidence suggests preeclampsia also has implications for the mother beyond pregnancy, as well as long-term effects on offspring health. The objective of the present study is to determine the effect of ozone therapy administered in form of mayor autohemotherapy in hypertensive pregnant women at her 18th week gestation. Prescribed regular antihypertensive drugs were maintained. The application of ozone significantly (p<0.05) improved tensional figures and a significant dose reduction of the regular antihypertensive therapy was achieved. No side-effects were observed during the study. This study confirms and adds strong evidence that ozone therapy is an effective and safe method of treating hypertensive disorders during pregnancy preeclampsia
Potential economic impact assessment for cattle parasites in Mexico. Review

Here, economic losses caused by cattle parasites in Mexico were estimated on an annual basis. The main factors taken into consideration for this assessment included the total number of animals at risk, potential detrimental effects of parasitism on milk production or weight gain, and records of condemnation on livestock byproducts. Estimates in US dollars (US$) were based on reported yield losses in untreated animals. These estimates reflect the major effects on cattle productivity of six parasites, or parasite group. The potential economic impact (US$ millions) was: gastrointestinal nematodes US$ 445.10; coccidia ( Eimeria spp.) US$ 23.78; liver fluke ( Fasciola hepatica ) US$ 130.91; cattle tick ( Rhipicephalus microplus ) US$ 573.61; horn fly ( Haematobia irritans ) US$ 231.67; and stable fly ( Stomoxys calcitrans ) US$ 6.79. Overall, the yearly economic loss due to the six major parasites of cattle in Mexico was estimated to be US$ 1.41 billion. Considering that the national cattle herd registered in 2013 included 32.40 million head, the estimated yearly loss per head was US$ 43.57. The limitations of some of the baseline studies used to develop these estimates, particularly when extrapolated from local situations to a national scale, are acknowledged. However, the general picture obtained from the present effort demonstrates the magnitude and importance of cattle parasitism in Mexico and the challenges to maximize profitability by the livestock industry without adapting sustainable and integrated parasite control strategies.
Electronic, Mechanical and Elastic Anisotropy Properties of X-Diamondyne (X = Si, Ge)

The three-dimensional (3D) diamond-like semiconductor materials Si-diamondyne and Ge-diamondyne (also called SiC4 and GeC4) are studied utilizing density functional theory in this work, where the structural, elastic, electronic and mechanical anisotropy properties along with the minimum thermal conductivity are considered. SiC4 and GeC4 are semiconductor materials with direct band gaps and wide band gaps of 5.02 and 5.60 eV, respectively. The Debye temperatures of diamondyne, Si- and Ge-diamondyne are 422, 385 and 242 K, respectively, utilizing the empirical formula of the elastic modulus. Among these, Si-diamondyne has the largest mechanical anisotropy in the shear modulus and Young’s modulus, and Diamond has the smallest mechanical anisotropy in the Young’s modulus and shear modulus. The mechanical anisotropy in the Young’s modulus and shear modulus of Si-diamondyne is more than three times that of diamond as determined by the characterization of the ratio of the maximum value to the minimum value. The minimum thermal conductivity values of Si- and Ge-diamondyne are 0.727 and 0.524 W cm−1 K−1, respectively, and thus, Si- and Ge-diamondyne may be used in the thermoelectric industry.
Real-Time Pricing and Electricity Market Design

This paper considers two related distortions in electricity markets: the lack of real-time retail pricing and the suppression of peak wholesale prices due to Installed Capacity requirements. I lay out a framework for understanding these problems using a two-stage entry model in which producers with multiple technologies set capacity and then sell electricity into wholesale markets as demand varies over time. The model is calibrated to supply and demand conditions in the PJM electricity market. I estimate that moving from 10 percent of consumers on real-time pricing to 20 percent would increase welfare in PJM by $120 million per year. However, the welfare gains from clearer signals of scarcity prices under an Energy Only market design are more than twice as large. Furthermore, equilibrium peak prices in the Energy Only design drop to reasonable levels once a moderate share of retail consumers are on real-time pricing. JEL Codes: D04, D24, L10, L51, L94, Q41, Q47.
Quality of Experience Factors for Mobile TV Users

This chapter helps the professionals involved in the Mobile TV industry to methodically engineer the Quality of Experience (QoE) of Mobile TV users. Its objective is to investigate the factors that influence the QoE of Mobile TV users. It also discusses the issues for strategic implications for the Mobile TV industry. We retrieved and categorized the majority of the critical works focusing on QoE for Mobile TV users. Then, we considered them and proposed a comprehensive road-map for improving the QoE of Mobile TV users. We present an approach to produce improvements to the Mobile TV customer experiences. This chapter proposes a seven-stage “road-map” to improvement, which develops the existing models. This study remains to be seen how the presented QoE factors– both amongst technologies and Mobile TV actors – will affect the potential for Mobile TV amongst various types of users. The proposed road-map can help to bridge gaps between other studies that have either focused on QoE for mobile TV or have addressed frameworks for mobile TV.
Super–light metainterfaced plasmon–polaritons

The present work brings a simple design of and revealing the superluminal properties of plasmon – polaritons at the interface of hyperbolic metamaterial Ag/TiO2 and external dielectric medium SiO2. Effective medium theory (EMT) services as a framework of the simulation carried out and provides an insight into spectral dynamics of plasmon–polaritons velocities in the tested energy range of 0.5 ÷ 8 eV. The simulation predicts that the group velocity of the quasi–particles considered can exceed velocity of light in vacuum up to 2.8 times and change own sign from positive to negative depending on metamaterial parameters. At this the phase velocity of the plasmon–polaritons traveling along the interface exceeds the value of light velocity in vacuum up to 4 times. Subluminal features of the model assist to the superluminal ones as well and incorporate an unique property observed as light stop. Transmission lines, digital electromagnetic devices, memory and transformation units may utilize the findings revealed.
RBC deformability fractionation and hydrodynamic trapping for studying Plasmodium Falciparum infection

There have been several studies which indicate a preferential invasion towards younger red blood cells (RBCs) for the malarial parasite, P. Falciparum. Knowledge about a preferential mechanism could aid in the development of novel anti-malarial drugs. While the preference in these reports has been studied with density-separation of red blood cells, separating the cells by deformability may be a more accurate method of isolating groups of RBCs with differing age. This thesis has investigated the details of separating RBCs by deformability in the microuidic technique Deterministic Lateral Displacement (DLD). RBCs have been observed to undergo strong deformation in the device but the large size variation of RBCs together with RBC shape transformations inside the shallow channels have interfered with the separation by deformability. Further studies where higher device driving pressures with alternative device designs are utilized and the deformability of the separated cells are benchmarked towards existing techniques are proposed. Furthermore, on-chip invasion of trapped RBCs has been investigated using hydrodynamic trapping arrays. The trapping arrays allow for convenient and highly-controllable investigation of the invasion dynamics. The trapping arrays have been fabricated using replica molding and been used to successfully immobilize RBCs. Trap occupancy rates up to 85% over the span of 14 min have been achieved. On-chip parasitic behavior has been investigated. It involved several complications including the prevention of late-stage parasite rupture due to shape transformation of RBCs into echinocytic (crenated cells) when introduced into shallow PDMS (polydimethylsiloxane) channels. This complication seem to affect the rupturing of late-stage infected RBCs inside the channels. Alternative materials and surface-coating should be explored to minimize any channel-derived artefacts.
BEST PRACTICES IN BUSINESS PROCESS REDESIGN: SURVEY RESULTS AMONGST DUTCH AND UK CONSULTANTS

This paper describes and discusses the results of a survey we have undertaken in 2003/2004 amongst Dutch and UK consultants in the field of Business Process Redesign (BPR). It describes a set of best practices in BPR we wanted to test. In the paper we explain how the survey was conducted and describe the participants’ profiles. We also highlight the major survey’s findings.
Big Data Analytics for Personalized Recommendation Systems

Nowadays, large volumes of valuable data of different degrees of veracity can be easily generated or collected at a high velocity from a wide variety of data sources. Embedded in these big data are implicit, previously unknown and potentially useful information and knowledge. Hence, big data analytics are in demand as they assist users to analyze the big data and discover new knowledge. This in turn helps users gain insight into big data, obtain useful information, and make personalized recommendation. In this paper, we focus on big data analytics on music—i.e., music analysis—for personalized music recommendation systems. In particular, we present a system that exploits the frequent tags attached to the tracks in an user's listening history and a hidden Markov model (HMM) for generating predictions and thus making personalized recommendation. Knowledge learned from this personalized music recommendation can be transferred to building other personalized recommendation systems.
Marital Adjustment: A Predictor of Better Maternal Relationship

Abstract Marital harmony is an important dimension of parent-child relationship. Present study was an attempt to understand the role of marital harmony in determining quality of mother-teen relationships. The total sample comprised of 300 respondents (100 each of mothers, sons and daughters) selected purposively from four zones of Ludhiana city. A self designed sociodemographic questionnaire was used to identify mothers that fulfilled the inclusion criteria set for the present study. The quality of mother-teen relationship as perceived by mothers was assessed. Marital adjustment of the mothers was also investigated to study its impact on mother-teen relationship. The results of the study revealed that majority of mothers had good marital relationships. Mothers having good marital relations had less conflicts and more realistic expectations from their sons and daughters. Mothers with average marital adjustment were significantly over protective for their daughters than the mothers with good or poor marital adjustment. With increase in marital adjustment mothers became more accepting and realistic in their expectations. Mothers’ protecting and loving attitude for daughters increased significantly with increase in marital adjustment. The marital adjustment of the mothers contributed significantly to the daughter-mother relationship.
Public Knowledge about Dementia in China: A National WeChat-Based Survey

Dementia is a serious public health problem. The more extensive dementia knowledge is, the more conducive it is to early prevention and treatment of dementia. However, no assessment of the general population’s dementia awareness has been conducted so far in China. Thus, this study assessed the national public knowledge of dementia based on mobile internet in China. We assessed 10,562 national respondents recruited based on the most popular social networking service in China, WeChat and analyzed the data using quantitative methods. The overall correct rate of total dementia knowledge was 63.14%. Only half of the participants (50.84%) could identify risk factors accurately. The level of dementia knowledge was positively associated with high education, city residency, and experience of exposure to information on dementia. The sandwich generation (aged 20–60 years) had the highest level of dementia knowledge. Chinese people were found to have a low level of knowledge about dementia, especially those aged over 60 years, with low education and living in rural areas. Further educational programs and campaigns are needed to improve dementia knowledge, with greater focus on the older population as the target audience, emphasis on dementia risk factors as educational content, correcting misconceptions about dementia, and providing more experience of exposure to dementia.
Spatial Variability Analysis of Heavy Metals in Street Dusts of Kashan City

صخاش دناوت یم هک تسا هدش لیکشت یا هدیچیپ دماج تارذ زا ینابایخ رابغ و درگ :فده و هنیمز یناکم لیلحت ،ییاسانش هعلاطم نیا فده ،ور نیا زا . دشاب یرهش تسیز طیحم یگدولآ نییعت یارب یبسانم . تسا ناشاک رهش ینابایخ رابغ و درگ رد دوجوم نیگنس تازلف یگدولآ یبایزرا و تظلغ و دش یروآ عمج ناشاک رهش حطس زا ینابایخ رابغ و درگ هنومن 50 عومجم رد :یسررب شور یارب )Igeo( یگتشابنا نیمز صخاش . دش یریگ هزادنا اهنآ رد Cd و Cr ،Ni ،Fe ،Zn ،Pb ،Cu تازلف . دش هیهت GIS طیحم رد ینابایخ رابغ و درگ رد تازلف تظلغ یناکم یوگلا و دش هدافتسا یگدولآ دروآرب ینابایخ رابغ و درگ رد Cu و Pb ،Ni ،Fe ،Cr ،Cd ،Zn تظلغ نیگنایم هک داد ناشن جیاتن :اه هتفای . تسا 45/58 mg/kg و 45/18 ،13/62 ،16589/77 ،37/12 ،0/43 ،237/21 بیترت هب تظلغ زا رتشیب ینابایخ رابغ و درگ رد Fe و Zn ،Cu ،Pb تازلف تظلغ هک داد ناشن نینچمه جیاتن قبط . داد ناشن ار Cr > Cd > Ni > Cu > Zn > Pb یلوزن دنور زین Igeo صخاش جیاتن . تسا هنیمز نابوتا یلصا یاه نابایخ ،رهش زکرم رد ،رابغ و درگ رد تازلف یاه تظلغ نیرتشیب یناکم یوگلا لیلحت . دش هدهاشم ینوکسم قطانم رد اه تظلغ نیرتمک و ناشاک -مق هدوب یناسنا Zn و Cu ،Pb تازلف اشنم هک دسر یم رظن هب ،هتفرگ تروص یاه لیلحت قبط :یریگ هجیتن Ni تازلف هک یلاحرد ،دنا هتفرگ رارق یناسنا یاه تیلاعف ریثات تحت یدودح ات زین Cd و Fe تازلف و تازلف تظلغ شیازفا یلصا لماع لاامتحا ،یتعنص یاه تیلاعف و کیفارت . دنراد یعیبط لاماک اشنم Cr و . تسا ناشاک رهش رد نیگنس تسی ز
Organic Vegetables Quality Arising from the Brazilian Family-Run Farm

The present study has its aim to evaluate the different dimensions of organic vegetables quality from the Brazilian family-run farm, especially the evaluation of composition, antioxidant activity, microbiological characteristics and pesticide residues. There were evaluated carrot, broccoli, kale and white cabbage grown by organic farmers in the highlander region of Rio de Janeiro state. There were determined humidity, lipids grade, total protein content, mineral residues (ashes), soluble and insoluble fibers, soluble solids, total acidity, pH, and pesticide residues. The antioxidant activity was determined using DPPH (2, 2-diphenyl-1-picrylhydrazyl) free radical removal. Among the analyzed vegetables, the effectiveness of the antioxidant capacity was obtained, in decreasing order, by broccoli, kale, white cabbage and carrot. According to the microbiological parameter, evaluated vegetables have shown satisfactory sanitary quality. Pesticide residues were not found above the detection limit for both authorized and unauthorized analyzed crops.
Logistics Of a cer United Nations World Food Programme Khartoum Sudan

With the increase in humanitarian crises and consequent aid, there is greater demand for evidence of the effectiveness and accountability of aid. Information Systems (ISs) are critical for emergency response and humanitarian operations in fulalling these demands, but also because the consequences of having or not having timely and accurate data are usually life and death. IS innovation in the context of the humanitarian sector highlights the need for contextbased approaches to innovation. In this article, we explore the process of the improvement, development, and implementation of an international development organization’s logistics and supply chain system in Chad. Actor-network theory provides the framework for making sense of this IS.