Miracle-dz/UniFAR-FTUs huggingface dataset:
Neoadjuvant Short- or Long-Term Radio(chemo)therapy for Rectal Cancer: How and Who Should Be Treated?

There are two general approaches to preoperative radiotherapy (RT) in rectal cancer: short-course (25 Gy in 5 fractions) radiation with immediate surgery and long-course 5-fluorouracil (5-FU)-based chemoradiotherapy (CRT; 50.4 Gy in 28 fractions) with surgery scheduled 6–8 weeks thereafter. While it is clear that downsizing and downstaging effects are more pronounced with long-course CRT and delayed surgery, a Polish randomized trial and, more recently, an Australian phase III trial demonstrated no significant differences in long-term oncologic outcomes and late toxicity rates between either preoperative concept. Ongoing studies currently address short-course preoperative RT with a longer interval to surgery (Stockholm III trial), and short-course RT with sequential combination chemotherapy in patients with synchronous distant metastasis. With respect to the long-course CRT approach, newer-generation chemotherapeutics as well as molecularly targeted agents have been tested within phase I–III studies, both as induction/adjuvant chemotherapy as well as during concomitant CRT. Evidently, the monolithic approaches to either apply the same schedule of preoperative 5-FU-based CRT to all patients with TNM stage II/III rectal cancer or to give preoperative short-course RT for all patients with resectable rectal cancer irrespective of tumor stage and location need to be questioned. The inclusion of different multimodal treatments into the surgical oncological concept, adapted to tumor location, stage, and individual patient risk factors and preferences is upcoming. Clearly, future developments will aim at identifying and selecting patients for ideal treatment alternatives.
Regulation of lac Operon Expression: Reappraisal of the Theory of Catabolite Repression

The physiological state of Escherichia coli with respect to (permanent) catabolite repression was assessed by measuring the steady-state level of β-galactosidase in induced or in constitutive cells under a variety of growth conditions. Four results were obtained. (i) Catabolite repression had a major effect on fully induced or constitutive expression of the lac gene, and the magnitude of this effect was found to be dependent on the promoter structure; cells with a wild-type lac promoter showed an 18-fold variation in lac expression, and cells with the lacP37 (formerly lac-L37) promoter exhibited several hundred-fold variation. (ii) Exogenous adenosine cyclic 3′,5′-monophosphoric acid (cAMP) could not abolish catabolite repression, even though several controls demonstrated that cAMP was entering the cells in significant amounts. (Rapid intracellular degradation of cAMP could not be ruled out.) (iii) Neither the growth rate nor the presence of biosynthetic products altered the degree of catabolite repression; all variation could be related to the catabolites present in the growth medium. (iv) Slowing by imposing an amino acid restriction decreased the differential rate of β-galactosidase synthesis from the wild-type lac promoter when bacteria were cultured in either the absence or presence of cAMP; this decreased lac expression also occurred when the bacteria harbored the catabolite-insensitive lacP5 (formerly lacUV5) promoter mutation. These findings support the idea that (permanent) catabolite repression is set by the catabolites in the growth medium and may not be related to an imbalance between catabolism and anabolism.
Improving QoE and Fairness in HTTP Adaptive Streaming Over LTE Network

HTTP adaptive streaming (HAS) has emerged as the main technology for video streaming applications. Multiple HAS video clients sharing the same wireless channel may experience different video qualities as well as different play-out buffer levels, as a result of both different video content complexities and different channel conditions. This causes unfairness in the end-user quality of experience. In this paper, we propose a quality-fair adaptive streaming solution with fair buffer (QFAS-FB) to deliver fair video quality and to achieve asymptotically fair play-out buffer levels among HAS clients competing for the same wireless resources in a long-term evolution (LTE) cell. In the QFAS-FB framework, the share of radio resources is optimized according to video content characteristics, play-out buffer levels, and channel conditions. The proposed solution is compared with the other state-of-the-art strategies, and the numerical results show that it significantly improves the quality fairness among heterogeneous HAS users, reduces the video quality variations, and improves the fairness among the user's play-out buffers.
The ventro‐basal complex of the thalamus: types of cells, their responses and their functional organization

Volleys in cutaneous nerves and afferent impulses initiated by tactile and joint-stimulation produce potential changes and also evoke the discharge of impulses in a quite sharply demarcated region of the contralateral thalamus, which is virtually coextensive with the ventro-basal complex (VBC) (Mountcastle & Henneman, 1949, 1952; Rose & Mountcastle, 1952; Poggio & Mountcastle, 1963). There have been extensive investigations of the activation of these VBC cells, as they will henceforth be called, by various forms of peripheral stimulation, and in particular Rose & Mountcastle (1954) studied with great detail and precision the repetitive spike discharges that are evoked by single volleys in cutaneous nerves: for example, the effect of variations in volley size on the number and frequency of the constituent impulses of the response, and also an analysis of the inter-spike intervals. Poggio & Mountcastle (1963) paid particular attention to the location, modality responsiveness and topographic organization of the individual VBC cells. On the basis of the dynamic properties, particularly the relation between stimulus frequency and response frequency, they reached the conclusion that virtually all VBC cells belong to a single uniform class, which is characterized by the fidelity of response to rapid repetitive stimulation of afferent nerves, there being on the average frequency following up to 100-120 sec. Purpura & Cohen (1962) and Purpura & Shofer (1963) very successfully employed intracellular recording in order to analyse the responses evoked by stimulation of the mid-line thalamic nuclear complex. They demonstrated for the first time the large and prolonged post-synaptic inhibitory potentials of cells of the nucleus ventralis anterior, and the influence of these powerful inhibitions on spontaneous and evoked discharges. They
Early Versus Late Blood Transfusion in Puerperal Septic Shock Patients with Anemia-a Quasi-Experimental Controlled Trial

Objective: To compare the outcome of early blood transfusion i.e. within 6hrs. (hours) of admission VS late blood transfusion (after 6 hrs.) in puerperal septic shock patients with anemia. Study design: A prospective quasiexperimental controlled trial in ICU(intensive care unit) of lady Willingdon hospital, a tertiary care hospital of Obstetrics and gynecology from Aug2013 to July 2016. Population: Patients admitted with septic shock and anemia during puerperium in ICU . Methods: 74 patients were included in the study by purposive sampling technique. Exclusion criteria were an irreversible shock, chronic lung, and heart disease or those requiring surgical intervention. Surviving sepsis campaign guidelines were followed for the management of these patients. Effect of blood transfusion on the recovery of these subjects was studied. The study group consisted of 43 patients in which blood was transfused within 6hrs. of admission. Control group had 31 patients in whom blood could not be transfused within this period. The demographic features and outcome of both groups were recorded and entered on spss20 statistical package. Results: The time of recovery from hypotension, tachycardia, pulmonary edema, ventilator and cardiac support was significantly shorter in the study group compared to the control. A lesser number of blood transfusions was required to treat anemia in the study group. Maternal mortality was less in the study group (23.25%) as compared to control group (48.39%) with an odds ratio of decrease in maternal mortality of 0.323(.119-.877). Conclusion: Early blood transfusion shortens the time of recovery and decreases maternal mortality and morbidity in puerperal septic shock patients with anemia.
A Simple and Tunable Single-Bandpass Microwave Photonic Filter of Adjustable Shape

A simple and tunable single-bandpass microwave photonic filter of adjustable shape is proposed and experimentally demonstrated. The filter is based on multiple sources (spectrum-sliced by a Mach-Zehnder interferometer) and two cascaded incoherent optical structures, namely, a dispersion medium of 50-km single-mode fiber and a fiber ring delay line. In the experimental range from 1.0 to 3.8 GHz, a discretely tunable single-bandpass filter with a high Q-factor or a flat-top response is achieved by carefully matching the transfer functions of the two individual optical structures.
The Influence of Spelling Ability on Vocabulary Choices When Writing for Children With Dyslexia

Spelling is a prerequisite to expressing vocabulary in writing. Research has shown that children with dyslexia are hesitant spellers when composing. This study aimed to determine whether the hesitant spelling of children with dyslexia, evidenced by frequent pausing, affects vocabulary choices when writing. A total of 31 children with dyslexia, mean age 9 years, were compared to typically developing groups of children: the first matched by age, the second by spelling ability. Oral vocabulary was measured and children completed a written and verbal compositional task. Lexical diversity comparisons were made across written and verbal compositions to highlight the constraint of having to select and spell words. A digital writing tablet recorded the writing. Children with dyslexia and the spelling-ability group made a high proportion of spelling errors and within-word pauses, and had a lower lexical diversity within their written compositions compared to their verbal compositions. The age-matched peers demonstrated the opposite pattern. Spelling ability and pausing predicted 53% of the variance in written lexical diversity of children with dyslexia, demonstrating the link between spelling and vocabulary when writing. Oral language skills had no effect. Lexical diversity correlated with written and verbal text quality for all groups. Practical implications are discussed and related to writing models.
Perceptual oriented depth cue enhancement for stereoscopic view synthesis

The depth cue enhancement can provide better stereo perception for viewers. However, the previous direct depth remapping approach did not consider the perceptual factor of human eyes; which could easily result in viewing discomfort. This paper presents a perceptual oriented depth cue enhancement with nonlinear disparity mapping. This mapping increases the depth resolution of viewer focused depth range (for better stereo perception) and more importantly, it limits its range within the stereoscopic comfortable zone. The above mapping strategy is modeled on normal distribution for easy, and user-specific adjustment. The experimental results show better stereoscopic viewing experiences when compared with results by the original disparity map.
SUPPLEMENT TO Deep Forest : Towards an Alternative to Deep Neural Networks

In this paper, we propose gcForest, a decision tree ensemble approach with performance highly competitive to deep neural networks in a broad range of tasks. In contrast to deep neural networks which require great effort in hyper-parameter tuning, gcForest is much easier to train; even when it is applied to different data across different domains in our experiments, excellent performance can be achieved by almost same settings of hyper-parameters. The training process of gcForest is efficient, and users can control training cost according to computational resource available. The efficiency may be further enhanced because gcForest is naturally apt to parallel implementation. Furthermore, in contrast to deep neural networks which require largescale training data, gcForest can work well even when there are only small-scale training data.
Catecholamine inhibition of prolactin secretion by isolated rat adenohypophyses.

Rat adenohypophyses were incubated in medium 199 containing l-14C-glycine or a Krebs-Ringer-bicarbonate solution with glucose and a mixture of essential and non-essential amino acids. Dialyzed medium and anterior pituitary homogenates were elect rophoresed on polyacrylamide gel. After staining with Amido Black, the growth hormone and prolactin bands were quantified by microdensitometry and cut from the gel column for measurement of radioactivity. Growth hormone and prolactin contained in the medium were also measured by radioimmunoassay techniques. Epinephrine and norepinephrine inhibited prolactin release into the medium and this was associated with a proportionate rise in anterior pituitary prolactin. The catecholamines decreased total radioactive glycine incorporated into medium and pituitary prolactin but after 4 hr of incubation this decrease was not statistically significant. Inhibition of prolactin release occurred with concentrations of . 5 μg/ml or greater of norepinephrine, and 1 μg/ml or greater.
Why is Obamacare so controversial?

Erroneous research results have potential for harm far beyond the patients recruited into the study, because the leverage of leadership permits them to alter behaviour of thousands of clinicians for many years. Medical research does not yet have as well-developed and rapid-responding safety systems as other spheres where lives are at stake. As doctors we would all leap to assist in a medical emergency for a patient not formally underourcare.Yet,whenproblemsoccurinclinicalresearch,wedonotyethavegoodmechanismstoallworktogetherquicklyanddecisivelyto improve patient safety. In this article we describe how each of us, regardless of our role, can (and perhaps should) take active steps to support delivery of reliable science for patient care. - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Keywords
The Profile and Motivations of Elderly Woinen Gainblers

Survey research was conducted to determine the profile and motivations of elderly women gamblers. The survey results indicate there is potential to increase revenues by appealing to this segment. Those that do visit casinos, do so primarily for the entertainment and excitement it provides. Furthermore, as a group, elderly women gamblers are disciplined and do not suffer from compulsive gambling problems.
Synergistic Effect of Low Doses of Tumor Necrosis Factor and Sera from Patients with Systemic Lupus Erythematosus on the Expression of Procoagulant Activity by Cultured Endothelial Cells

Summary The effect of 15 antiphospholipid antibody (APA) positive SLE sera, 13 APA negative SLE sera, 10 APA negative sera from patients with other connective tissue diseases (CTD) and 15 control sera on the expression of endothelial procoagulant activity (PCA) was studied. Endothelial cells (EC) were stimulated with tumor necrosis factor (TNF) and 20% serum for 4 hr and the surface PC A expression was measured. Without TNF, none of the sera stimulated PC A expression. With subop timal TNF stimulation, 14/15 APA positive SLE sera, 7/13 APA negative SLE sera, 2/10 CTD sera and 2/15 control sera enhanced PC A expression. This stimulating effect resided in the IgG fraction and was associated with the presence of APA, but not with a history of thrombosis. Purified APA had no PC A stimulating activity. PC A expression was inhibited by cycloheximide and heat treatment (30 min, 56° C) of serum. In conclusion, 21/28 (75%) SLE sera increase the TNF-induced endothelial PC A expression. Although this effect predominantly occurs with APA positive serum, a causative role of APA was not demonstrated.
INTERACTIONS OF VITAMIN E WITH VITAMIN C, VITAMIN B12, AND ZINC

In the past, clarification of the interaction of vitamin E with selenium, polyunsaturated fatty acids, vitamin A, and iron has led to an understanding of many previously perplexing observations concerning vitamin E status in man and animals. The interactions of vitamin E with vitamin C, vitamin B,,, and zinc are less well explored. Greater knowledge of these interactions will, undoubtedly, lead to a better understanding of both the biochemical function of vitamin E and the clinical manifestations of a deficiency of this vitamin.
Voltage regulation of stand-alone photovoltaic system using boost SEPIC converter with battery storage system

This paper proposes a regulated DC power supply through photovoltaic (PV) panel and battery for standalone DC application. The system is composed of PV panel, Maximum Power Point Tracking (MPPT) controller using DC-DC boost converter, voltage regulator and battery. The control algorithm aims to extract maximum power from the PV array and manages the power transfer to the DC load using a DC-DC SEPIC converter, respecting the available storage level. The designed system simultaneously supplies the DC power and charge the battery during PV power generation. The control of the output voltage and energy storage is of great significance as the output voltage of the converter depends upon the solar radiation and load.
Implications of the Facing Dementia Survey for the general population, patients and caregivers across Europe

The Facing Dementia Survey included interviews with approximately 1200 members of the general public, 600 persons who served as primary caregivers for a person with Alzheimer's disease (AD) and 96 persons with AD. Members of the general public and the caregivers indicated level of agreement on a 5‐point scale to a series of attitudinal statements about the disease as well as other diagnostic questions. Persons with AD underwent a qualitative interview. Results indicate that Europeans are acutely aware of the potentially devastating consequences of AD, but few are familiar with the early‐stage symptoms. Most members of the general population accept that early intervention and therapy are key to slowing the effects of the disease. Caregivers often delayed consulting a physician about a loved one's behaviour, partly because of uncertainty about early signs of AD. They also expressed doubt about the ability of physicians to make the diagnosis. Caregivers experience profound effects of AD in every area of their life – emotional, physical, social and financial. Persons with AD responded to their diagnosis in one of three ways: a fatalistic attitude, a belief that their problems are linked to old age or a lack of acceptance. Survey respondents from three populations were critical of the level of government investment in and support of AD.
A Review of Treatment Options for Co-Occurring Methamphetamine Use Disorders and Depression

AbstractCo-occurring methamphetamine use and depression interferes with treatment outcomes. Female methamphetamine users are known to have higher rates of depression than male methamphetamine users, although this is also true for the general population. There are limited treatment options for the management of depression among methamphetamine users. In this integrative review, we summarize data on treatment strategies for co-occurring depression and methamphetamine use disorders. English-language articles were identified from PsychINFO, CINAHL, PubMed, and Medline as well as from reference lists of key articles. Search terms included “methamphetamine,” “depression,” and “treatment. ” Research articles describing psychological (n = 3), pharmacological (n = 6), nutritional supplement (n = 1), and psychological combined with pharmacological (n = 3) approaches for the treatment of methamphetamine use or withdrawal and/or depression are included in this review. Psychological and combination of psychological with pharmacological approaches have not been shown to be effective in treating these co-occurring conditions. Antidepressants have been determined to be ineffective and/or to introduce side effects. Gender differences with response to treatment were examined in only one of the published studies. There is a large gap in knowledge regarding treatment of co-occurring methamphetamine use disorders and depression. Considering that female methamphetamine users experience higher rates of depression than men, a focus on gender-specific treatment approaches is warranted.
Improvement of the accuracy of absolute magnetic encoders based on automatic calibration and the fuzzy phase-locked-loop

This paper presents an approach for the improvement of the accuracy of absolute magnetic encoders (AME). The encoders comprise the following two magnets: a multipolar magnet to increase the resolution and the accuracy, and a center-located bipolar magnet for the calculation of the absolute angle. The multipolar signal processing is crucial for the increasing of the encoder accuracy; however, the multipolar signals are not ideal, i.e, dc offsets, different amplitudes, phase shifts, and random noise. The present paper proposes a calibration method that is based on the adaptive linear neural network (ADALINE) for the reduction of the effect of the nonidealities. In addition, to optimize the loop-acquisition time and to enhance the random-noise reduction, the bandwidth is adapted using the fuzzy phase-locked-loop (F-PLL). This method is simulated using Matlab software and is implemented on the ARM STM32F405R. The study results demonstrate the efficient high performance that can be achieved with the use of the proposed method.
The Biochemistry and Physiology of Bone

The stated purpose of this book is to "make the study of human tissue available to the student who has only a minimal knowledge of the human body. " The text reads easily and clearly and covers a great deal of material in an economical and straight-forward manner. The illustrations are accurate and beautifully executed but so small and delicate that they are apt to be somewhat confusing to the student who is not familiar with the material beforehand. This book could best be put to use for students of nursing or paramedical personnel. Perhaps the author had in mind this audience, since he gives greater treatment to some subjects than is usual in a histology text, such as background in the organization and physiology of the nervous system, which such students are not apt to encounter. The book cannot be recommended for premedical, medical, graduate students, or teachers, since the material is not presented in such a manner which would make it a contribution to the study of anatomy on the elementary level for such persons. Writing an elementary text is always a challenge. When properly done, simplification can be elightening and can be used by students at all levels of study. The present text does not display imagination or investiveness in this regard but is rather a simplistic summary of the basic facts. Its usefulness is therefore limited.