Miracle-dz/UniFAR-FTUs huggingface dataset:
The Novel Regulatory Role of lncRNA-miRNA-mRNA Axis in Amyotrophic Lateral Sclerosis: An Integrated Bioinformatics Analysis

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease that primarily affects motor neurons, causing muscle atrophy, bulbar palsy, and pyramidal tract signs. However, the aetiology and pathogenesis of ALS have not been elucidated to date. In this study, a competitive endogenous RNA (ceRNA) network was constructed by analyzing the expression profiles of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) that were matched by 7 ALS samples and 4 control samples, and then a protein-protein interaction (PPI) network was constructed to identify the genes related to ALS. Gene Ontology (GO) was used to study the potential functions of differentially expressed mRNAs (DEmRNAs) in the ceRNA network. For the ALS and control groups, 247177 potential lncRNA-mRNA ceRNA relationship pairs were screened. Analysis of significant relationship pairs demonstrated that the PPI modules formed by the MALAT1-regulated SYNRG, ITSN2, PICALM, AP3B1, and AAK1 genes may play important roles in the pathogenesis of ALS, and these results may help to characterize the pathogenesis of ALS.
IBM Submission for TAC KBP: EDL 2019 Cascaded Fine-Grained Named Entity Recognition

In this paper we describe our submission to the TAC KBP: Entity Linking and Discovery 2019 task. The task aims at extracting ﬁne-grained mentions of 190 types from text where no training data is available for these types. Our submissions are based on a two pass approach: ﬁrst detect nine basic NER types, followed by a second pass of reﬁning these types into the destination ﬁne-grained types.
Adapting Fitness and Neuromotor Self-Tracking Over the Life Span

Teaching self-assessment helps participants monitor their progress as well as “feel good, move well, and live life with purpose. ” As HFPs, we also want to “do no harm” while helping people take personal responsibility to meet their goals. This article addresses simple health-related physical fitness tests, which evaluate progress, instill motivation, and establish attainable fitness goals while preserving the structural integrity of the human body. Apply It! After reading this article, the health and fitness professional will • Learn how to empower clients to take personal responsibility for their functional movement throughout the life span • Explore self-tracking designed to teach clients to assess and record health-related and neuromotor movement patterns • Apply behavioral and coaching theories to the application of self-assessment to prevent musculoskeletal issues while engaging in regular movement practices.
Consideration of Vector-Borne and Zoonotic Diseases during Differential Diagnosis

The authors suggest that healthcare practitioners’ consideration of vector-borne and/or zoonotic disease is largely dependent on the scope and specificity of education received during and after their professional training. They further suggest that this training is desperately lacking in the medical field and needs to be addressed. Objective Recognition and reporting of vector-borne and zoonotic disease (VBZD) cases is largely dependent upon the consideration of such diseases by healthcare practitioners during the initial diagnosis and ordering of specific confirmative diagnostic tests. This study was conducted to assess the general knowledge and understanding of VBZD transmission and clinical presentation. Methods Healthcare practitioners were surveyed to determine the extent of training and educational experiences they received relative to VBZDs, and their likelihood to consider such diseases during differential diagnoses. In addition, an assessment of their knowledge of arthropod species that may transmit VBZD pathogens was conducted. Results Having postprofessional school training relevant to VBZDs significantly influenced diagnostic accuracy for such disease cases based on the presented clinical signs and symptoms. Conclusions The prevalence of VBZDs in the United States likely is significantly underestimated. The authors suggest the enhancement of VBZD-focused education as an important initiative that would significantly improve timely diagnosis, treatment, and, ultimately, prevention of these diseases.
Relationship between health literacy and fast food consumption: A population-based study from southern Iran

Background: Having appropriate health literacy may affect the consumption of fast food. We aimed to evaluate the effect of health literacy on fast food consumption among the adult populations.Methods: We evaluated health literacy and fast food consumption using an appropriate questionnaire in 421 adult participants with the age range of 18-65 years old in Fasa city, Fars Province, southern Iran. Two-step cluster sampling and, then, systematic sampling were performed. Data collection was done through demographic information questionnaire, checklist on fast food consumption, and the Health Literacy for Iranian Adults (HELIA) questionnaire. Data were harvested by face-to-face conversations. Population data across groups with/without fast food intake were compared.Results: Most of our participants used fast food every few months (49.9%). People with low or unstable income consumed more fast food than others (P<0.05). Sandwich and hotdog were the most consumed fast food (60.8%) and pizza was in the next step (34.9%). Sausage and soda were the most seasoning food (66.7%). Most of our participants used fast food as dinner (67.9%) and along with their family (72.2%), suggesting the institutionalized consumption of this type of food in the family. Fun was the most frequent reason for the use of fast food (66.5%). Most of the participants completely knew about the raw materials for fast food and their adverse effects. Finally, we found that health literacy among those who used fast food was less than those who did not consumed fast food. This difference was also observed in the subscales of reading skills, critique, and decision-making.Conclusions: It seems differences in health literacy and its components can affect fast food consumption. In addition, there was a negative relationship between health literacy and fast food consumption, which was also observed in reading skills, critique, and decision-making.
Rare Earth Ions Adsorption onto Graphene Oxide Nanosheets

ABSTRACT Graphene oxide (GO) was synthesized and used as a coagulant of rare earth elements (REEs) from aqueous solution. Stability and adsorption capacities were exhibited for target REEs such as La(III), Nd(III), Gd(III), and Y(III). The parameters influencing the adsorption capacity of the target species including contact time, pH, initial concentration, and temperature were optimized. The adsorption kinetics and thermodynamics were studied. The method showed quantitative recovery (99%) upon desorption using HNO3 acid (0.1 M) after a short contact time (15 min).
Phthalate contamination in aquatic environment: A critical review of the process factors that influence their removal in conventional and advanced wastewater treatment

ABSTRACT Phthalates are dialkyl or alkyl aryl ester derivatives of phthalic acid and environmental endocrine-disrupting compounds. For their wide usage in plastic manufacturing and personnel care products as well as the potential to leach out from products, phthalates have been worldwide detected in aquatic environment. Phthalate-laden treated wastewater is among the main source of their environmental contamination. The authors provide a critical review of contamination level of phthalates in the aquatic environment including surface, ground and drinking water. The contamination level of phthalates is highest in wastewater followed by surface water, groundwater, and drinking water. A main source of phthalate contamination in aquatic sources is phthalate-laden wastewater treatment effluents. Therefore, process factors influencing their removal in conventional and advance oxidation processes (AOPs) of wastewater treatment are summarized in the review. Better removal of phthalates in conventional wastewater treatment is favored by enhanced solid separation, sludge retention time (15 days), hydraulic retention time (11 days), and a combination of redox environments. In AOPs, presence of organic matter, process coupling with adsorbents, and pH may influence the removal of phthalates. Overall this review can provide a collective background to conceive the extent of phthalate contamination in aquatic environment and recognize factors that may improve removal of phthalates and minimization of their release into the environment.
SOME PHARMACOLOGICAL ACTIVITIES OF HEXADEC-12-ENOIC ACID ISOLATED FROM CHENOPODIUM AMBROSIOIDES LINN

The extractive (labelled Sc), from Chenopodium ambrosioides (Linn), which had been characterised as hexadec-12-enoic acid in an earlier work, was tested for analgesic, antipyretic and anti-inflammatory activities. The result for the acetic acid induced writhing test for Sc revealed very high activity, 96.77%, being significantly higher than that of the standard, aspirin i.e. acetyl salicylic acid, (64.68 %). The hot plate analgesic test showed that the activity was not significant and was short-lived compared to that of morphine. The test for antipyretic activity revealed that it possessed not only antipyretic but also hypothermic activity 3 hours after administration. The anti-inflammatory activity of hexadec-12-enoic acid may be involved prostaglandin synthesis inhibition.
PHYLOGENETIC ANALYSIS OF VP7 GENE OF ROTAVIRUS STRAINS CIRCULATING IN CHILDREN WITH ACUTE GASTROENTERITIS IN CHENNAI WITH FOCUS ON G2

Background: Group A rotavirus is the leading cause of gastroenteritis among children worldwide and accounts for 872000 hospitalizations, 3270000 outpatient visits and predictable 78000 deaths annually in India. As the disease burden is more common in low income countries including India, monitoring and detection of the circulating strains of rotavirus needs to be monitored. This study emphasis the genetic relatedness among G2 rotavirus strains that was analyzed during the study period in and around Chennai, Tamilnadu during pre-vaccination era. Materials and Methods: We collected fresh stool from child < 5 years admitted with acute gastroenteritis (AGE) admitted to hospitals. Rotavirus infections were detected by enzyme immune assay. Positive rotavirus isolates were genotyped using semi-nested type-specific multiplex PCR for G and P types and were sequenced. Phylogenetic analysis of VP7 genes of G2 were carried out and the variations between strains isolated globally were documented. Results: Group A rotaviruses was detected in 77 (39.48%) samples and samples of G2 was identified in more percentage and results indicated it would be re-emerging strain/genotype. The deduced amino acid sequences of the antigenic regions of VP7 exposed substitutions at various positions correlated with changes compared to other strains by phylogenetic analysis. Conclusion: Since rotavirus is transmitted through oral-fecal route and monitoring of environmental cleanliness is of mandatory to cease the spread of this deadliest viral agent and covering single genotype/strains before the prevaccination era will have to be modified with respect to the circulating strains as vaccine candidate.
HPLC fingerprint of Radix Fici in medicated diet

The fingerprint of Radix Fici in medicated diet by HPLC was established and the medicinal materials that can be used as evaluation index of medicated diet were explored.Chromatographic conditions of HPLC were as follows:Waters Shield RP C18 column(250 mm×4.6 mm,5 μm),methanol(A) and 0.1% phosphoric acid(B) as gradient mobile phases,flow rate 1.0 mL/min and detecting wavelength at246 nm,and column temperature 30 ℃. Fingerprint was established with 14 common peaks and determination of Psoralen was the highest.Similarity was in the range of 0.90-0.99 and methodology reached the required standard.Characteristic constituents of Radix Fici could be detected in the medicated diet,which was appropriate for the evaluation index of medicated diet.The impact of fatty acid on detection of characteristic constituents of Radix Fici was small.
A comprehensive review of the traditional plant based medicines for the treatment of rheumatism

Inflammation is a highly complex mechanism and can be described as the body's first defensive immune system reaction. The immediate purpose is to guard against infectious invasions, the introduction of antigens, any cell and tissue disruption or harm. If it is not treated, it is persistent which progresses to serious degenerative conditions such as rheumatism, atherosclerosis and asthma. Rheumatism is a category of inflammatory disease with chronic conditions. The disease includes a rise in the amount of neutrophils, lymphocytes and monocytes, which primarily influence the synovial fluid of the movable joints and eventually cause cartilage and bone degradation across the joints. Many steroidal and nonsteroidal drugs (Methotrexate, Cyclosporine and Dpencillamine, Ibuprofen, Sulindac, Indomethacin) are prescribed as treatment therapies. But, unfortunately, all these drugs are having side effects. So, to enhance the pharmacological effects and decrease the side-effects of the available treatment therapies, there is a need to move towards alternative therapies. By keeping the limitations of the existing therapies, in the present review, we tried to summarize the data of traditional medicinal plants with maximum pharmacological activities with less side effects for the rheumatism patients. A systematic literature and electronic archive analysis was performed using internet search engines such as Google scholar, Pubmed, Medlineplus, and Science Direct from numerous academic publications. This review paper is summarized with total 500 articles out of which 330 articles are selected to review for extracts and parts used, chemical constituents, traditional uses and for reporting anti rheumatic activity.
Management of Atopic Dermatitis in Children: 2020 Review by the Guidelines Development Panel of Hong Kong College of Paediatricians

The Guidelines Development Panel on "Management of Atopic Dermatitis (AD) in Children" has performed the first updated review on the topic since the publication of the management guidelines by the Hong Kong College of Paediatricians in 2013. While most of the recommendations of the original guidelines are still valid, various management issues are further elaborated based on recent evidences in addition to the latest international and regional guidelines. Using validated clinical scores for assessment of severity of AD are advocated by the European guidelines to guide stepwise management and monitor progress. There are more evidences to support the proactive approach with use of topical anti-inflammatory agents as long-term treatment for the control of chronic recurrent AD. Topical corticosteroids remain first line topical agents for AD, while topical calcineurin inhibitors are indicated for sensitive areas and can be used as maintenance treatment. The role of newer therapeutic agents including topical phosphodiasterase 4 inhibitors, biologics and allergen immunotherapy for use in paediatric patients are deliberated. Management of itch, tackling issues of steroid phobia and compliance remain challenges in AD management. The concepts of skin barrier dysfunction in AD and targeting the skin for allergy prevention strategies are discussed.
Polyembolokoilamania: Foreign Body Insertion in the Abdomen and the Rectum

Bharath stated that the introduction of foreign bodies into one’s own body is one of the uncommon types of self-mutilation. There is a relative dearth of literature discussing its predisposing factors, complications and management. Children commonly swallow foreign bodies, most of these are accidental ingestion. In adolescents, intentional foreign body insertion often reflects risk taking behaviour. Adults may suffer from co-morbid psychiatric disease, harbour lingering curiosities that manifest as experimentation or as auto-eroticism. While psychiatric causes have been hypothesized as the underlying aetiology, its incidence in this cohort remains to be established. Foreign body insertion in these individuals is associated with highly repetitive behaviour, it may occur as a response to command hallucinations, for example in schizophrenia. Foreign bodies can enter the human body by swallowing, insertion or by traumatic force, either accidental or deliberate. The authors describe two cases of foreign body insertion (a plastic bottle and sewing needles) involving the rectum and the abdomen presenting to the Emergency Department. A non-judgemental and open-minded approach is crucial, ensuring privacy, professionalism and empathy towards a patient presenting to triage as staff reactions such as titillation or disgust can impact negatively on compassionate patient care. Successful management involves a collaborative approach involving primary care physicians, emergency physicians, surgeons and psychiatrists. Even after extraction, delayed perforation or significant bleeding from the rectum may occur. Unearthing the aetiology for foreign body insertion can lead to management strategies that target the motivation for the behaviour. This paper will provide an overview of its aetiology, clinical presentation and management.
Main Manuscript for Meeting the unmet needs of clinicians from AI systems in cardiology: A systematic formulation, and a suggested framework

Despite their great promise, artificial intelligence (AI) systems have yet to become ubiquitous in the daily practice of medicine, largely due to several crucial unmet needs of healthcare practitioners. These include lack of explanations in clinically meaningful terms, handling the presence of unknown medical conditions, and transparency regarding the system's limitations, both in terms of statistical performance, as well as recognizing situations for which the system's predictions are irrelevant. We formulate these unmet clinical needs as machine-learning (ML) problems, then systematically address them with cutting-edge ML techniques. We focus on electrocardiogram (ECG) analysis, as an example domain where AI has great potential, and tackle two challenging tasks: the detection of a heterogenous mix of known and unknown arrhythmias from ECG, and the identification of underlying cardio-pathology from segments annotated as normal sinus rhythm, recorded in patients with an intermittent arrhythmia. We validate our methods by simulating a screening for arrhythmias in a large-scale population while adhering to statistical significance requirements. Specifically, our system (a) visualizes the relative importance of each part of an ECG segment for the final model decision; (b) upholds specified statistical constraints on its out-of-sample performance and provides uncertainty estimation for its predictions; (c) handles inputs containing unknown rhythm types; (d) handles data from unseen patients, while also flagging cases where the model’s outputs are not usable for a specific patient. This work represents a significant step towards overcoming the limitations currently impeding the integration of AI into clinical practice, in cardiology and medicine in general.
Business Process Re-engineering and Information Security Business Process Re-engineering and Information Security Planning: Opportunities for integration Planning: Opportunities for integration

Business process re-engineering (BPR) has come to recognize a need for the adoption of socio-technical methodologies and capabilities for knowledge representation of qualitative concerns. Security planning and decision-making has a similar need, and furthermore socio-technical methods common to BPR can be usefully applied in this capacity. The introduction of security models like Defense-in-Depth and similar efforts to recognize the organizational impact of security planning in operational security management serve as an initial step in educating security personnel and provide a more comprehensive view, but unfortunately, security decision-making has traditionally relied almost solely upon quantitative risk assessment, cost/benefit mechanisms, and related, functionalistic methodologies. This greatly limits the representational capacity of the decision process, and with it the possible dimensions of analysis in which to consider security issues. Within this paper, we briefly examine security planning and the relevant techniques of BPR and Socio-technical design, and present a framework for their integration within the context of information security. It is our contention that such methodologies can be utilized in the security decision process to facilitate representation of subjective concerns and broadly-defined issues germane to security policy, within an organizational context.
Theoretical Study of EUXIT 50 KI Epoxy and its Hardener using Hyperchem-8 Program

The work includes a theoretical study of the epoxy and its derivative where it was done by the program of hyperchem-8 using molecular mechanics and semi-empirical calculations. The heat of formation (ΔH○f), binding energy (ΔEb) and total energy (ΔEtot.) of the epoxy and its derivative were calculated using the PM3 method at 298 K. Also, PM3 was used to evaluate the bond length and vibrational spectra of epoxy (A1) and epoxy with hardener complex (A2). The experimental values were compared with theoretical results that agree with those found experimentally.
Joint Pairing and Structured Mapping of Convolutional Brain Morphological Multiplexes for Early Dementia Diagnosis

Diagnosis of brain dementia, particularly early mild cognitive impairment (eMCI), is critical for early intervention to prevent the onset of Alzheimer’s Disease (AD), where cognitive decline is severe and irreversible. There is a large body of machine-learning based research investigating how dementia alters brain connectivity, mainly using structural (derived from diffusion MRI) and functional (derived from resting-state functional MRI) brain connectomic data. However, how early dementia affects cortical brain connections in morphology remains largely unexplored. To ﬁ ll this gap, we propose a joint morphological brain multiplexes pairing and mapping strategy for early MCI detection, where a brain multiplex not only encodes the relationship in morphology between pairs of brain regions, but also a pair of brain morphological networks. Experimental results con ﬁ rm that the proposed framework outperforms in classification accuracy several state-of-the-art methods. More importantly, we unprecedentedly identi ﬁ ed most discriminative brain morphological networks between eMCI and NC, which included the paired views derived from maximum principal curvature and the sulcal depth for the left hemisphere and sulcal depth and the average curvature for the right hemisphere. We also identified the most highly correlated morphological brain connections in our cohort, which included the (pericalcarine cortex, insula cortex) on the maximum principal curvature view, (entorhinal cortex, insula cortex) on the mean sulcal depth view, and (entorhinal cortex, pericalcarine cortex) on the mean average curvature view, for both hemispheres. These highly correlated morphological connections might serve as biomarkers for early MCI diagnosis.
APOBEC3G Variant (rs6001417) CG and GG Genotypes and their protective feature against HIV-1 Infection in Pakistani Dwelled Community

Results: Three genotypes of rs6001417 (CC, CG and GG) were compared both in HIV-1 infected patients and healthy control groups (p=0.73, p=0.007, p=0.01 respectively). The rs6001417 CG and GG genotype demonstrated a significant involvement in both the healthy and infected individuals and portraying possible protective effect against HIV-1 infection with predictive value of 36.43% and 13.57% respectively.