Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Sequence Comparison on Potential Protein Targets- Lung, Liver and Prostate Cancers using Bioinformatics Tools

INTRODUCTION Worldwide, lung cancer is the most common cancer among men in terms of both incidence and mortality, and among women has the third highest incidence, and is second after breast cancer in mortality. In 2012, there were 1.82 million new cases globally, and 1.56 million deaths due to lung cancer, representing 19.4% of all deaths from cancer. The highest rates are in North America, Europe and East Asia, with over a third of new cases in 2012 in China. Rates in Africa and South Asia are much lower [1]. The population segment most likely to develop lung cancer is people aged over 50 who have a history of smoking. In contrast to the mortality rate in men, which began declining more than 20 years ago, women's lung cancer mortality rates have been rising over the last decades, and are just recently beginning to stabilize [2]. In the USA, the lifetime risk of developing lung cancer is 8% in men and 6% in women [3]. Globally more than 1 million people get colorectal cancer every year [4] resulting in about 715,000 deaths as of 2010 up from 490,000 in 1990 [5]. As of 2012 it is the second most common cause of cancer in women (9.2% of diagnoses) and the third most common in men (10.0%) with it being the fourth most common cause of cancer death after lung, stomach, and liver cancer. Colorectal cancer was 10% of cancers in men and 9.2% of cancers in women. It is more common in developed than developing countries [6]. Globally incidences vary 10-fold with highest rates in the Australia, New Zealand, Europe and the US and lowest rates in Africa and South-Central Asia [7]. As of 2012, prostate cancer is the second most frequently diagnosed cancer (at 15% of all male cancers) and the sixth leading cause of cancer death in males worldwide [8]. In 2010 it resulted in 256,000 deaths up from 156,000 deaths in 1990 [9]. Rates of prostate cancer vary widely across the world. Although the rates vary widely between
Comparison of the use of neutrophil: lymphocyte count ratio (NLCR) to total leukocyte count in diagnosing appendicitis in adults with right iliac fossa pain

Introduction: Diagnosis of acute appendicitis (AA) is purely based on history, examination and few laboratory investigations. However, it is often a perplexing diagnostic problem during the early stages of the disease. Failure to make an early diagnosis is a primary reason for morbidity and mortality. Elevated leukocyte count is one of the indicators of appendiceal inflammation in patients with right iliac fossa pain and most of the patients with acute appendicitis present with leucocytosis. Recently, it has been seen that the neutrophil: lymphocyte count ratio (NLCR) is a more sensitive marker than leukocytosis in patients with acute appendicitis. Method: This is a prospective observational study conducted over a period of one year in the department of surgery at the Tribhuvan University Teaching Hospital, from September 2013 to August 2014. The clinical diagnosis of Acute appendicitis was made by history and clinical examinations and laboratory investigations. Total leukocyte count (TLC) and NLCR of patients diagnosed as AA were measured and recorded in the pro forma. Histological diagnosis was taken as the final diagnosis. Results: A total of 106 patients were included in the study. Two third of the patients were male. Right iliac fossa tenderness was the most common sign. Ultrasound was able to diagnose acute appendicitis in 40.65% of the cases. NLCR> 3.5 was observed in 90.56% of patients with acute appendicitis, whereas 78.3% of patients had leukocytosis only. High NLCR (5.60) is associated with complicated AA. Conclusion: NLCR is a more sensitive laboratory parameter than TLC in patients with RIF pain to diagnose acute appendicitis. A high NLCR ratio has a high likelihood of a complicated AA.
Goals, Success Factors, and Barriers for Simulation-Based Learning

Introduction: This study describes (a) process goals, (b) success factors, and (c) barriers for optimizing simulation-based learning environments within the simulation setting model developed by Dieckmann. Methods: Seven simulation educators of different experience levels were interviewed using the Critical Incident Technique. Results: (a) The main process goals were to enhance learning, engage participants, and aid the application of what was learned during the course. (b) As success factors, educators stated their own competencies and attitudes, motivation and openness of participants, and a functional environment. (c) As barriers, educators stated a lack of willingness to actively engage in simulation by the participants and time pressure. The results emphasize the need to consider jointly the interrelated elements of simulation-based learning environments to optimize the use of educational simulation. Discussion: The results support the applicability of Dieckmann’s setting model to describe simulation-based courses and emphasize the diversity of factors that need to be considered in optimizing simulation practice. This article can serve as a practical aid for educators within health care simulation settings and in other domains.
The Relationship of Serum Heat Shock Protein 70 Antibody Levels with the Inflammatory Factors and Serum Uric Acid Levels in Hemodialysis Patients

Background: Heat shock proteins are extracellular inﬂammatory intermediaries and intracellular cytoprotective molecules. De-spitemanystudiesonintracellularHSP70,theclinicalassociationbetweeninﬂammatorybiomarkersandextracellularHSP70anti- body (anti-HSP70) levels is not well-studied. Objectives: The aim of this study was to investigate whether raised serum anti-HSP70 in hemodialysis (HD) patients are related to levels of serum inﬂammatory markers and uric acid, as the key players, in the pathogenesis of the disease. Methods: This cross-sectional study was carried out from January 2018 to July 2018, on patients referred by the nephrologists from the central outpatient dialysis center of a governmental university-aﬃliated hospital, in Ahvaz, Iran. Ninety HD patients enrolled basedontheinclusionandexclusioncriteria. Bloodsampleswerecollecteddirectlyfromthearteriovenousﬁstulabeforearoutine HDsession. Thecirculatinglevelsof anti-HSP70,highlysensitiveC-reactiveprotein(hs-CRP),Interleukin-6(IL-6),andendotoxinwere measured by Enzyme-linked immunosorbent assay (ELISA). Results: The univariate regression analysis revealed a signiﬁcant association between serum anti-HSP70 level and diabetes mellitus, hypertension, hemodialysis vintage, uric acid, hs-CRP, and IL-6 (P < 0.05). In a multiple regression model, after adjusting for confounders, the associationbetween circulatinganti-HSP70and uricacid (B= 16.92, P= 0.001), hs-CRP (B=11.77, P= 0.002), IL-6(B = 2.87, P = 0.002), endotoxin (B = 0.14, P = 0.005), and hemodialysis vintage (B = 43.76, P = 0.002) was signiﬁcant. Conclusions: Ourﬁndingssuggestthatthedevelopmentof theexcessivesystemicinﬂammatoryresponseanduricacidcontribute to a higher serum anti-HSP70 leading to cardiovascular disease.
EFFICACY AND SAFETY OF OBINUTUZUMAB + LENALIDOMIDE + ATEZOLIZUMAB IN PATIENTS WITH RELAPSED OR REFRACTORY FOLLICULAR LYMPHOMA: PRIMARY ANALYSIS OF A PHASE 1B/2 TRIAL

EFFICACY AND SAFETY OF OBINUTUZUMAB + LENALIDOMIDE + ATEZOLIZUMAB IN PATIENTS WITH RELAPSED OR REFRACTORY FOLLICULAR LYMPHOMA: PRIMARY ANALYSIS OF A PHASE 1B/2 TRIAL F. Morschhauser | N. Ghosh | I. Lossos | M.L. Palomba | A. Mehta | O. Casasnovas | D. Stevens | S. Chitra | A. Knapp | T. Nielsen | M. Oestergaard | M. Wenger | G. Salles Institute of Hematology-Transfusion, Centre Hospitalier Régional Universitaire de Lille, Lille, France; Hematologic Oncology and Blood Disorders, Levine Cancer Institute/Atrium Health, Charlotte, NC, United States; Division of Hematology, Department of Medicine, University of Miami, Miami, FL, United States; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States; Division of Hematology and Oncology, University of Alabama School of Medicine, Birmingham, Alabama, United States; Service d'Hématologie clinique, CHU Dijon Bourgogne Hôpital François Mitterrand, Dijon, France; Norton Cancer Institute, Norton Healthcare, Louisville, KY, United States; Product Development Oncology, F. Hoffmann-La Roche Ltd, Basel, Switzerland; Oncology Biomarker Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland; Haematology Department, Université Claude Bernard de Lyon, Lyon University Hospital, Villeurbanne, France
AB1302B CHRONIC KIDNEY DISEASE IN RHEUMATOID ARTHRITIS: PREVALENCE AND RISK FACTORS

Background The problem of chronic kidney diseases (CKD) in rheumatoid arthritis (RA) patients have not been fully studied. The role of biological therapy (BT) is poorly understood. Objectives Aim of the study was to examine the prevalence, risk factors and histological variants of CKD in RA, and impact of pharmacotherapy. Methods 135 patients with RA from 2013 to 2018 were enrolled in this study. Age, gender, duration of RA, drug therapy, ESR, CRP, DAS28, renal function, proteinuria (PU), histological variants were analyzed. Arterial hypertension, weight index, serum lipids and glucose levels were also assessed. Results The incidence of CKD in RA was 30.4% (41 from 135). CKD 3-4 stages with eGFR < 60ml/min/1.73m2 was detected in 14.8% patients. The duration of the disease, high ESR and DAS28 score, NSAIDs treatment and hyperlipidemia were risk factors for CKD in RA (Fig 1). We also found negative correlation between the DAS28 and eGFR (Fig. 2). Amyloidosis was the most common histologic pattern (51.52%), followed by chronic glomerulonephritis (CGN) (24.24%) and tubulo-interstitial nephritis (24.24%). Among CGN mesangial glomerulonephritis was the most frequent (Table 1). Renal amyloidosis was associated with a duration of RA, presence of systemic symptoms and CRP level. The levels of PU were lower, and eGFR levels were higher in patients treated with BT than in patients treated with synthetic disease-modifying anti-rheumatic drugs (DMARDs) (Fig 3). Conclusion CKD is often developed in patients with high RA activity. Treatment with biological agents is associated with a lower PU and higher GFR levels. References [1] Tokoroyama T, Ando M, Setoguchi K, Tsuchiya K, Nitta. K. Prevalence, incidence and prognosis of chronic kidney disease classified according to current guidelines: a large retrospective cohort study of rheumatoid arthritis patients. Nephrol Dial Transplant (2016) 0: 1–8 doi: 10.1093/ndt/gfw315 [2] Masako Kochi, Kentaro Kohagura, Yoshiki Shiohira,Kunitoshi Iseki, and Yusuke Ohya Inflammation as a Risk of Developing Chronic Kidney Disease in Rheumatoid Arthritis. PLoS One. 2016; 11(8): e0160225 [3] Kim HW, Lee CK, Cha HS, Choe JY, Park EJ, Kim J. Effect of anti-tumor necrosis factor alpha treatment of rheumatoid arthritis and chronic kidney disease. Rheumatol Int. 2015 Apr;35(4):727-34. doi: 10.1007/s00296-014-3146-4.Abstract AB1302B Table 1 Renal histopathologic findings in RA patients (n=33) Histological forms n % Amyloidosis: 21 63.7 Chronic glomerulonephritis:- Mesangial GN:IgA nephropathyIgM nephropathyMembranoproliferative GN- Minimal change disease- Membranous nephropathy- Diffuse nephrosclerosis 127412113 36.321. 212.13. 06.03. 03.09. 1Figure 1Figure 1Figure 1 Disclosure of Interests None declared
Fast speaker adaptation for speech recognition systems

Different speaker adaptation methods for speech recognition systems adapting automatically to new and unknown speakers in a short training phase are discussed. The adaptation techniques aim at transformations of feature vectors, optimized with respect to some constraints. Two different adaptation strategies are discussed. The first one is based on least mean-squared-error optimization. The second method is a codebook-driven feature transformation. Both adaptation techniques are incorporated into two different recognition systems: dynamic time warping (DTW) and hidden Markov modeling (HMM). The results show that in both systems speaker-adaptive error rates are close to speaker-dependent error rates. In the best case the mean error rate of four test speakers decreases by a factor of six compared to the interspeaker error rate without adaptation. A hardware realization of the speaker-adaptive HMM-recognizer is described. <<ETX>>
Pauses as indicators in story structure (Benin)

The main claim of this paper is that Fongbe storytellers structure their performance by pauses. The research is based on the Fongbe Verbal Art texts called hwènùxó, which were collected by the author in Benin in 1976. The main objective of this paper is to gain a better insight into the performance of Fongbe verbal art texts. This includes the storytellers’ way of speaking and the question whether, and if so to what extent, their performance is driven by the stories’ content. My working assumption will be that speakers use various types of pauses as content markers. These pauses thus reflect the storyline in the mind of the performer (see Longacre 1990:2). The performance is structured by a consciously planned pattern of silences indicating, for instance, the end of a paragraph. In this pattern, long pauses are used to signal moments of special interest, such as the peak (i.e. the climax of tension and/or confrontation), the main theme, a flash-forward, or a cliff-hanger (see Longacre 1990:8).
CONKAT: a connectionist knowledge acquisition tool

Presents the integration of neural networks with a rule based expert system. The system called CONKAT (CONnectionist knowledge Acquisition Tool) realizes the automatic acquisition of knowledge out of a set of examples. It enhances the reasoning capabilities of classical expert systems with the ability of generalise and the handling of incomplete cases. CONKAT uses neural nets with unsupervised learning algorithms to extract regularities out of case data. A symbolic rule generator transforms these regularities into PROLOG rules. The generated rules and the trained neural nets are embedded into the expert system as knowledge bases. In CONKAT's diagnosis phase it is possible to use these knowledge bases together with in human experts' knowledge bases in order to diagnose a unknown case. Furthermore CONKAT is able to diagnose and to complete inconsistent data using the trained neural nets exploiting their ability to generalise. <<ETX>>
Methods and Terminology for Phonetic Aspects of Incremental Disfluency Synthesis (Poster)

5. Method Packages (draft) System requirement 1: Buying Time ● The system is out of content, due to changes in speech plan, delays in delivery from the generator, etc. ● Try to bridge the appearing gap with as simple DFEs as possible (see 4.) ● If possible, apply LEN, if more time needed: SP, more: FP. ● Still more time needed? Try some REP Bielefeld University Faculty for Linguistics and Literary Studies Phonetics and Phonology Work Group Dialogue Systems Group 3. Incrementality in Dialogue Systems Why include DFEs into speech synthesis? (Skantze 2013) 4. Selected DFEs (open list)
FRI0553 CANAKINUMAB AS A FIRST-LINE AND SECOND-LINE BIOLOGIC FOR TREATMENT OF SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS IN CHILDREN UNDER 4 YEARS OF AGE

Background Development of biologics and their launching into clinical practice has yielded significant progress in pediatric rheumatology. Nevertheless, treatment of severe disorders, and systemic JIA in particular, still remains a challenge. JIA often has the early-onset form. If its course is aggressive and persistent, patients exhibit poor response to treatment with first-line biologics. Effectiveness of the second-line and subsequent biologics, as well as the optimal sequence of prescribing drugs belonging to different classes to children younger than 4 years, remains an open question Objectives To compare the efficacy of canakinumab (CAN) in children with sJIA younger than 4 years (in biologic-naïve patients and when prescribed as a second-line biologic). Methods The study was conducted as a subanalysis of the prospective cohort study to evaluate the efficacy of biologics in children with sJIA. Comparative analysis involved 17 patients who had initiated CAN treatment at the National Medical Research Center of Children’s Health (Moscow, Russia) when aged < 4 years (9 biologic-naïve patients (the naïve group) and 8 patients switched from tocilizumab therapy (the switched group)). Treatment efficacy was evaluated according to the dynamics of clinical and laboratory signs using the ACRPedi criteria. The Wallace criteria were used to evaluate whether or not remission had been achieved. Treatment safety was evaluated according to the data presented in the Adverse Event Reports Results At baseline, patients had comparable duration and severity of the disease. The biologic proved efficacious already after 4 weeks of treatment. Five (55.6%) patients in the naïve group and 4 (50%) patients in the switched group achieved ACR90 (p>0.999) within one year of treatment. A state of inactive disease according to the Wallace criteria was achieved in one patient in each group, (12.5% and 11.1%, respectively (p>0.999). JADAS-71 decreased significantly from 12.8 (IQR 10.4-16.2) to 4.4 (IQR 2-6.8) in the naïve group (p=0.012) and from 11.6 (IQR 8-13.88) to 2.35 (IQR 1-3.03) in the switched group (p=0.017). Conclusion CAN was found to be highly efficacious and have a good safety profile in children younger than 4 years regardless of prior biologic treatment. Disclosure of Interests None declared
A neural fuzzy system to evaluate software development productivity

Managing software development and maintenance projects requires early knowledge about quality and effort needed for achieving this quality level. Quality-based productivity management is introduced as one approach for achieving and using such process knowledge. Fuzzy rules are used as a basis for constructing quality models that can identify outlying software components that might cause potential quality problems. A special fuzzy neural network is introduced to obtain the fuzzy rules combining the metrics as premises and quality factors as conclusions. Using the law of DeMorgan, this net structure is able to learn premises just by changing the weights. Note that the authors change neither the number of neurons nor the number of connections. This new type of net allows for the extraction of knowledge acquired by training on the past process data directly in the form of fuzzy rules. Beyond that, it is possible to transfer all the known rules to the neural fuzzy system in advance. The suggested approach and its advantages towards common simulation and decision techniques is illustrated with experimental results. Its application area is in maintenance productivity. A module quality model-with respect to changes-provides both quality of fit (according to past data) and predictive accuracy (according to ongoing projects).
Awareness Regarding Parkinson’s Disease: A Survey Report

Parkinson disease also known as paralysis agitans is a neurodegenerative disorder. It is thought to occur as a result of decline of dopamine secreting cells in substantia nigra. The common symptoms related to Parkinson are tremors, rigidity, slowness of movement and dementia. The purpose of this study was to evaluate awareness regarding Parkinson disease, its cause, symptoms, diagnosis and treatment. The survey is conducted based on questionnaire, in which general population belonging to different public universities and government hospitals were questioned regarding Parkinson disease. The ratio found was not upto our expectations as less than 55 people( out of 210) knew the name of the disease but only 18 of them were aware about the causes and symptoms associated with it and even lower awareness was observed regarding diagnosis and treatment of disease. From this survey we found that awareness regarding parkinsons disease is negligible in general population.
Protective Effect of Ethanol Extract of Celery (Apium graveolens L) on Kidney Damage in Ischemia/ Reperfusion Injury Rats Model

Ischemia/ reperfusion injury (IRI) is marked by the sudden decrease of blood supply to the kidney followed by restoration of blood flow. Ischemic acute kidney injury (AKI) is the leading cause of morbidity and mortality. Therefore, the prevention strategy for decreasing the damage due to IRI is required. Celery (Apium graveolens L) is often consumed as food. Celery has antioxidant and anti-inflammatory effects. This study aimed to investigate the protective effect of the celery on kidney damage in the kidney ischemia/ reperfusion injury rat model. Twenty-five rats male, 2-3 months old Sprague Dawley were divided into 5 groups: Group 1 was sham operation, group 2 was ischemia/ reperfusion injury (IRI), group 3, 4, 5 were IRI and 250 mg/kgBW, 500 mg/kgBW, 1000 mg/kgBW of ethanol extract of celery respectively for 14 days before and 3 days after operation. Blood serum sample was taken 3 days after the operation for measuring urea, creatinine, superoxide dismuthase (SOD) and nitrite oxide (NO). Hematoxylin-eosin (HE) staining was utilized to examine kidney tubular injury score. Data were analyzed using One-way ANOVA (p<0,05). The ethanol extract of celery at dose 1000 mg/kgBW prevented the increase of urea, creatinine serum, kidney tubular injury score and prevented the decrease of SOD, NO in the kidney ischemia/ reperfusion injury rat model (p<0,05). In conclusion, the ethanol extract of celery has a protective effect on kidney damage in the ischemia/ reperfusion injury rat model.