Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimental models of brain injury.

General categories of experimental brain injury models are reviewed regarding their clinical significance, and two new models are presented that use different methodology to produce injury. This report describes and characterizes the pathophysiologic changes produced by a novel fluid percussion (FP) method and a controlled cortical impact (CI) technique, both developed at the General Motors Research Laboratories (GMRL). The new models are compared to prior experimental brain injury techniques in relation to ongoing physical and analytical modeling used in automotive safety research by GMRL. Experimental results from our laboratory indicate that although the FP technique, currently the most widely used method for producing brain injury, is useful for producing graded injury responses systemically and centrally, it is not well-suited for detailed biomechanical analyses. This conclusion is based on high-speed cineradiographic studies where the physiologic saline in the FP cannula was substituted with a radiopaque contrast medium (Conray 1:1 dilution/saline). High speed x-ray movies (1000 fps) were taken of the fluid percussion pulse (1.5-3.4 atm/20 msec) in sagittal, dorsal, and frontal planes of orientation. When viewed together, the cineradiography revealed a complex, dynamic interaction between the injected fluid and the skull/cranial contents. Rapid lateral and anterior/posterior epidural fluid flow suggest that the pathology and dysfunction following FP brain injury reflects diffuse mechanical loading of the brain. Because fluid is used to transfer mechanical energy to brain tissue, and because fluid flow characteristics (i.e., direction, velocity, and displacement) are dependent on the brain geometry and species used, accurate analytical and biomechanical analyses of the resultant injury would be difficult at best. In contrast, the cortical impact model of experimental brain injury uses a known impact interface and a measurable, controllable impact velocity and cortical compression. These controlled variables enable the amount of deformation and the change in deformation over time to be accurately determined. In addition, the CI model produces graded, reproducible cortical contusion, prolonged functional coma, and extensive axonal injury, unlike the FP technique. The quantifiable nature of the single mechanical input used to produce the injury allows correlations to be made between the amount of deformation and the resultant pathology and functional changes. (ABSTRACT TRUNCATED AT 400 WORDS)
Tailored Chromatic Dispersion in Silicon-on-Insulator Slot Waveguides

We investigate the chromatic dispersion properties of silicon channel slot waveguides in a broad spectral region centered at ~1.5 μm. The variation of the dispersion profile as a function of the slot fill factor, i.e., the ratio between the slot and waveguide widths, is analyzed. Two different dispersion regimes are identified. Keywordsintegrated optics; silicon photonics; dispersion.
Relationship between TV viewers' preferences and psychophysiological measurements of emotional state

Using 3DTV, we experimentally estimated the relationship between TV viewers' emotional states and selected physiological indices. The results suggest near-infrared spectroscopy (NIRS), representing central nervous system activity, to be a potentially useful index for evaluating emotional states that include “feeling of involvement. ” The low frequency/high frequency ratio (LF/HF), which represents sympathetic nervous system activity and emotional state, appears to depend on the type of content. Our results also indicate the potential for improving accuracy of evaluation by combining complex emotional states into a physiological index, and for separately analyzing each group according to participants' preferences.
Current Status of Tissue Engineering Heart Valve

The development of surgically implantable heart valve prostheses has contributed to improved outcomes in patients with cardiovascular disease. However, there are drawbacks, such as risk of infection and lack of growth potential. Tissue-engineered heart valve (TEHV) holds great promise to address these drawbacks as the ideal TEHV is easily implanted, biocompatible, non-thrombogenic, durable, degradable, and ultimately remodels into native-like tissue. In general, three main components used in creating a tissue-engineered construct are (1) a scaffold material, (2) a cell type for seeding the scaffold, and (3) a subsequent remodeling process driven by cell accumulation and proliferation, and/or biochemical and mechanical signaling. Despite rapid progress in the field over the past decade, TEHVs have not been translated into clinical applications successfully. To successfully utilize TEHVs clinically, further elucidation of the mechanisms for TEHV remodeling and further translational research outcome evaluations will be required. Tissue engineering is a major breakthrough in cardiovascular medicine that holds amazing promise for the future of reconstructive surgical procedures. In this article, we review the history of regenerative medicine, advances in the field, and state-of-the-art in valvular tissue engineering.
Patient Controlled Encryption using Key Aggregation with Blowfish Algorithm

Cloud plays the vital role in internet world. Cloud provides storages, platforms which improves the functionality. Cloud storage shows how securely and flexibly we can store and share our data. With the help of keys user can easily and securely share their data over cloud. This introduces Key Aggregate Cryptosystem in which an aggregate key is created using which user can share their data partially over cloud and it provides a constant size ciphertext. In spite of traditional cryptographic key generation techniques, this technique possesses unique cryptographic key aggregate cryptosystem which is helpful for secure cloud and privacy preserving key generation process. We propose access level policy structure such as Public and Private Access level to improve the data access mechanism in the data sharing cloud mechanism process. We are using algorithm such as Blowfish algorithm which results in higher security and faster execution when compared to AES (Advanced Encryption standard) and DES (Data Encryption Standard). Also the blowfish algorithm is unpatented and no license is required
Bioinformatics Arabidopsis MPSS . An Online Resource for Quantitative Expression Analysis 1 [ w ]

We have developed a public Web-based resource to facilitate access to global expression data for Arabidopsis, available at http://mpss.udel. edu/at. Developing an understanding of patterns and levels of transcriptional activity is the starting point for analyzing individual genes or gene families. Genome-wide transcriptional analyses are also revealing the relationship between the structure and organization of a genome and the activity of the genes encoded in that genome. Whole-genome expression data can be obtained from a variety of technologies, including cDNA microarrays (DeRisi et al., 1997), oligonucleotide microarrays (Lockhart et al., 1996), serial analysis of gene expression (SAGE; Velculescu et al., 1995), and massively parallel signature sequencing (MPSS; Brenner et al., 2000a, 2000b). The diversity of microarray platforms, improving densities, relatively low cost per experiment, and the range of technologies (e.g. cDNA, short oligo, and long oligo) have made it easier for labs to obtain their own microarray data than to reanalyze publicly-released data. Tag-based expression data like SAGE and MPSS are more easily utilized by multiple labs because the data format is relatively standard, the genes that are analyzed are not preselected, and the per-library cost discourages unnecessary duplication of experiments. While online resources have been described for SAGE data (Lash et al., 2000; Ball et al., 2001), MPSS data have several unique aspects and must be treated in a different way than SAGE data (Meyers et al., 2004a). None of the existing Web sites for tag-based expression data are customized in a way that links plant genomic and expression data. We have developed a public, Web-based resource for the analysis of gene expression in the model plant, Arabidopsis. The database and interface is specialized to store and facilitate public access to gene expression data derived by MPSS. Our database currently contains more than 36,991,173 17-base sequence signatures and more than 31,404,553 20-base signatures derived by MPSS from more than 14 Arabidopsis libraries (Meyers et al., 2004a). The MPSS data and Arabidopsis genomic sequence and annotation were used as the basis for the development of publiclyavailable analysis and comparison tools. Our Web site (http://mpss.udel.edu/at) includes a genome viewer, a set of gene, signature, and library analysis pages, an FTP site for retrieval of the data, and a signature extraction tool to allow specific sequence comparisons to the MPSS data. In this report, we describe the development, organization, and utility of this resource.
MATERNAL TRANSFER OF PARAMYXOVIRUS TYPE 1 ANTIBODIES AND ANTIBODY RESPONSE TO A LIVE NEWCASTLE DISEASE VACCINE IN KORI BUSTARDS

Studies were conducted to monitor the decline of maternal antibodies to paramyxovirus type 1 (PMV-1) in kori bustard chicks (Ardeotis kori), and to determine the antibody response in birds with low levels of maternally derived immunity (MDI) after being given either one or five times the standard domestic fowl dose of a live PMV-1 La Sota vaccine intranasally. The results confirmed that PMV-1 antibodies were transferred to eggs and chicks derived from kori bustard hens immunized with inactivated vaccine 5 to 8 mo previously. The levels of inherited antibody in chicks varied considerably, with 21% of birds having no detectable antibodies at day 14. Chicks hatched from dams with high hemagglutination inhibition (HI) antibody titers had high titers of MDI. Mean antibody levels in seropositive chicks were log2 6.3 and log2 2.9 on days 14 and 42, respectively. The rate of decline of detectable antibodies (1 log2), was estimated to be 5.50 to 6.25 days and 12.25 days in 14 to 21 and 28 to 42 day old chicks, respectively. There was no significant HI antibody response in bustards given a primary vaccination of either one or five times the standard domestic fowl dose of live vaccine intranasally up to 3 wk post-vaccination. High levels of HI antibodies, log2 7.4, were detected in birds given a secondary dose of inactivated vaccine, but not in birds given a secondary dose of live vaccine at 2 wk post-vaccination.
High Efficiency Open Collector Adaptive Bias SiGe HBT Differential Power Amplifier

A high efficiency SiGe HBT differential power amplifier with an open collector adaptive bias was successfully demonstrated. A novel linearizer consists of an open collector heterojunction bipolar transistor bias circuit and an MOS feedback diode was proposed, which achieved better power added efficiency (PAE) than that of traditional adaptive bias circuits. The size effect of linearizer was investigated and the impedance ratio (R 1 /R 2 ) between the linearizer and the main amplifier was optimized by the factor of 3. The measured differential power amplifier achieved an output 1-dB compression point (P 1 dB ) of 18.7 dBm with PAE of 31.2%, the output second order intermodulation point (OIP 2 ) of 59 dBm, and third-order intermodulation point (OIP 3 ) of 28 dBm. Compared to traditional adaptive bias technique, the proposed linearizer power amplifier effectively improved the PAE. The fabricated die size including pads is less than 0.925 mm 2 and suitable for highly integrated linear drive amplifier.
Cluster analysis of gene expression dynamics

This article presents a Bayesian method for model-based clustering of gene expression dynamics. The method represents gene-expression dynamics as autoregressive equations and uses an agglomerative procedure to search for the most probable set of clusters given the available data. The main contributions of this approach are the ability to take into account the dynamic nature of gene expression time series during clustering and a principled way to identify the number of distinct clusters. As the number of possible clustering models grows exponentially with the number of observed time series, we have devised a distance-based heuristic search procedure able to render the search process feasible. In this way, the method retains the important visualization capability of traditional distance-based clustering and acquires an independent, principled measure to decide when two series are different enough to belong to different clusters. The reliance of this method on an explicit statistical representation of gene expression dynamics makes it possible to use standard statistical techniques to assess the goodness of fit of the resulting model and validate the underlying assumptions. A set of gene-expression time series, collected to study the response of human fibroblasts to serum, is used to identify the properties of the method.
Analysis between Escherichia Coli growth and physical parameters in water using Pearson correlation

Water quality may differ in at least two physical parameters from water system typically used to measure the growth of microbes: pH and temperature. This study is to determine the most significant water physical parameters associated with the growth of Escherichia coli (E. coli) strain in the laboratory. Water physical parameter in distilled water with cultures strain in nutrient broth were performed in sterile condition, testing the effects of E. coli growth and incubation temperature at 37 °C. Growth of E. coli data were analysed using Pearson correlation and the results show good relationship with pH (r=0.971), time (r=0.958), turbidity (r=0.885), dissolved oxygen (r=-0.861), and temperature (r=0.763). This study indicates five out of seven water physical parameters that are highly correlated with E. coli growth.
Primase Activity of Human DNA Polymerase α-Primase

DNA polymerase α-primase consists of four subunits, p180, p68, p58, and p48, and comprises two essential enzymatic functions. To study the primase activity of the complex, we expressed cDNAs encoding for the human p58 and p48 subunits either as single proteins or together using Escherichia coliexpression vectors. Co-expression of both primase subunits allowed the purification of a heterodimer in high yields that revealed stable primase activity. Purified recombinant p48 subunit showed enzyme activity, whereas purified p58 did not. In contrast to the heterodimer, the primase activity of p48 was unstable. The activity of p48 could be stabilized by the addition of the divalent cations Mg2+ and Mn2+ but not Zn2+. On a poly(dC) template the primase activity was hardly influenced by the monovalent cation potassium. However, by using poly(dT) as a template the recombinant p48 activity was sensitive to salt, whereas recombinant p58-p48 and the bovine DNA polymerase α-primase purified from thymus were less sensitive to the addition of monovalent cations. A complex of bacterially expressed primase and baculovirus-expressed p180 and p68 was assembled in vitro and shown to support replication of simian virus 40 DNA in a cell-free system.
A integração de fornecedores no processo de desenvolvimento de novos produtos na indústria de alimentos

As parcerias entre empresas clientes e fornecedoras sao cada vez mais frequentes no processo de desenvolvimento de novos produtos, principalmente em mercados altamente competitivos, que exigem precos baixos, qualidade e disponibilidade. Fatores essenciais para o sucesso sao: comunicacao, confianca e comprometimento. No caso de industrias de alimentos, a integracao de fornecedores, no processo de desenvolvimento de novos produtos, permite o acesso a tecnologia, a inovacao, a reducao de tempo dos projetos, como tambem a eficacia em custos. Palavras-chave: Parcerias cliente-fornecedor, Desenvolvimento de Produtos Alimenticios, Terceirizacao.
Presenting Risks Introduced by Android Application Permissions in a User-Friendly Way

Abstract The emergence of Android as a leading Operating System in terms of market coverage induced the rapid emergence of many mobile applications. A lot of these applications are prone to misuse because of their design. This paper deals with a new method of informing user whether applications installed on his device are potentially harmful or not. The introductory part provides some insight into security mechanisms used in Android. The main part deals with research we based our work on, proposal of our own methodology based on permission model and its implementation in application for real-time offline analysis of installed applications on device running Android. The last part of this paper deals with the evaluation of achievements reached by our methodology implemented in standalone application
What's for Lunch at the Conformational Cafeteria?

In this issue of Molecular Pharmacology, Mukhopadhyay and Howlett present evidence for ligand-selective conformations of the CB1 cannabinoid receptor with differential coupling to G proteins. Ligand-directed signaling to different cellular effector pathways extends drug selectivity beyond that afforded by differential affinity for different receptor subtypes. The challenge for pharmacologists of the future will be not only to identify ligand-selective receptor conformations but also to develop an understanding of the relationships between those conformations, cell function, and ultimately therapeutics. As we learn more about ligand-selective receptor conformations, it should be possible to develop response-selective drugs that maximize therapeutic efficacy and minimize unwanted effects.
Natriuretic peptides: a new lipolytic pathway in human adipocytes

Atrial natriuretic peptide (ANP) receptors have been described on rodent adipocytes and expression of their mRNA is found in human adipose tissue. However, no biological effects associated with the stimulation of these receptors have been reported in this tissue. A putative lipolytic effect of natriuretic peptides was investigated in human adipose tissue. On isolated fat cells, ANP and brain natriuretic peptide (BNP) stimulated lipolysis as much as isoproterenol, a nonselective β‐adrenergic receptor agonist, whereas C‐type natriuretic peptide (CNP) had the lowest lipolytic effect. In situ microdialysis experiments confirmed the potent lipolytic effect of ANP in abdominal s.c. adipose tissue of healthy subjects. A high level of ANP binding sites was identified in human adipocytes. The potency order defined in lipolysis (ANP > BNP > CNP) and the ANP‐induced cGMP production sustained the presence of type A natriuretic peptide receptor in human fat cells. Activation or inhibition of cGMP‐inhibited phosphodiesterase (PDE‐3B) (using insulin and OPC 3911, respectively) did not modify ANP‐induced lipolysis whereas the isoproterenol effect was decreased or increased. Moreover, inhibition of adenylyl cyclase activity (using a mixture of α2‐adrenergic and adenosine A1 agonists receptors) did not change ANP‐ but suppressed isoproterenol‐induced lipolysis. The noninvolvement of the PDE‐3B was finally confirmed by measuring its activity under ANP stimulation. Thus, we demonstrate that natriuretic pep tides are a new pathway controlling human adipose tissue lipolysis operating via a cGMP‐dependent pathway that does not involve PDE‐3B inhibition and cAMP production. —Sengenès, C. , Berlan, M. , De Glisezinski, I. , Lafontan, M. , Galitzky, J. Natriuretic peptides: a new lipolytic pathway in human adipocytes. FASEB J. 14, 1345–1351 (2000)
Using Multiple Drug Exposure Levels to Optimize Power in Pharmacogenetic Trials

Large‐scale pharmacogenetic trials testing tens to hundreds of thousands of single‐nucleotide polymorphisms (SNPs) will become possible in the near future given rapidly decreasing costs of genotyping. Devising optimal designs for these trials will be a significant challenge. The author demonstrates how the level of drug exposure may strongly affect the power to detect true associations between genetic polymorphisms and drug response. An analytic model of drug response is described that is used to simulate pharmacogenetic trials. Analytical and numerical sensitivity analyses are performed on the model to demonstrate possible exposure‐sensitivity behaviors. This model shows that the power to detect an association can be a nonlinear, nonmonotonic function of drug exposure. This model is further investigated using two clinical trial designs. The conclusion is that trial designs that use more than one drug exposure or dose will have an increased likelihood of discovering statistically significant pharmacogenetic associations.
Self-Management and the Many Facets of “ Non-Self ” Franco Zambonelli

The common perspective of nearly all “self-*” approaches is that of considering human beings as “non-self” from the information system perspective (Figure 1-a). Indeed, one of the very common goals of all approaches is to move humans out-of-the-loop, by making information systems able to perform in an autonomous way all that kind of (costly and often too complex to bear) human activity related to configuring and maintaining information systems so as to have them properly working under all conditions. However, beside this common perspective, a number of diverse conceptions co-exist for what should be actually considered “self” and what, beside humans, “non-self”.
Timed reachability analysis method for EFSM-based communication protocols and its experimental evaluation

We propose a timed reachability analysis method in order to generate system states of two classes of EFSM-based communication protocols; one class C1 consists of events such that the lower and upper bounds are all the same and the other class C2 consists of events such that they may be different. The proposed method enumerates only sequences of system states that are obtained through parallel execution of all possible events. Then, in order to evaluate the efficiency of the proposed method, we develop a verification tool based on the proposed method, and then apply the tool to a broadcasting protocol. The experimental results show that the total number of states generated by the proposed method is much less than that by the previous method.
Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene

Three herpes simplex virus mutants that contain drug resistance mutations in the DNA polymerase gene exhibited no significant reduction in replication in the ears of mice compared with the wild type after inoculation at that site but were attenuated for pathogenicity after intracerebral inoculation. Cataracts were common sequelae in mice that survived mutant infections.
A Decentralized Wiki as Web 2 . 0 Enterprise Collaboration Platform

Wikis are major applications of the Web 2.0; they are used for a large number of purposes, such as project documentation, and coordination, in open communities and in enterprises. At the application level, users are targeted as both consumers and producers of dynamic content. Yet today, this kind of peer-to-peer principle is not used: at the technical level, wikis are built using traditional clientserver architectures. What is lacking is a generic platform that combines the scalability of the peer-to-peer approach with, e.g., a wiki’s capability for consistent content management in a highly concurrent environment. This paper presents methods for a flexible content repository system that is intended to close the gap by using a hybrid peer-to-peer overlay to support scalable, fault-tolerant, and consistent data operations for the dynamic content of wikis. Major building blocks to enable peer-to-peer data management at the system's persistent storage layer are highlighted, and we show how these can be used to implement a peer-to-peer based wiki application, consisting of: (i) a peer-to-peer back-end to administrate a wiki's actual content resources; (ii) peer-to-peer service groups acting as indexing groups to implement a wiki's search index.