Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of methacrilyc thermosets coated with Silver-polysaccharide nanocomposite on HGFs adhesion in a S. mitis co-culture system

Silver based medical products have been proven to be effective in retarding and preventing bacterial growth, being silver reported to control infections since ancient times (1). In the field of dentistry, the use of silver ions/nanoparticles has been explored to counteract bacteria in resins and implants, as silver can destroy bacterial cell walls by reacting with the thiol groups (–SH) of proteins exposed to the extracellular portion of the bacterial membrane. Conversely, eukaryotic cells lack these exterior binding sites, so nanoparticles are supposed to interact with them only upon metal internalization (2). To reduce both bacterial adhesion to dental devices and cytotoxicity against eukaryotic cells, we coated BisGMA/TEGDMA methacrylic thermosets with a new material, Chitlac-nAg, formed by stabilized silver nanoparticles with a polyelectrolyte solution containing Chitlac. Here we analyzed the proliferative and adhesive ability of human gingival fibroblasts (HGFs) on BisGMA/TEGDMA thermosets uncoated and coated with AgNPs in a co-culture model system with Streptococcus mitis. After 48 h, HGFs well adhered onto both surfaces, while S. mitis cytotoxic response was higher in the presence of AgNPs coated thermosets. After 24 h thermosets coated with Chitlac as well as those coated with Chitlac-nAg exerted a minimal cytotoxic effect on HGFs, while after 48 h LDH release rised up to 20%. Moreover, the presence of S. mitis reduced this release mainly when HGFs adhered to Chitlac-nAg coated thermosets. The reduced secretion of collagen type I was significant in the presence of both surfaces even more when saliva is added. Integrin β1 localized closely to cell membranes onto Chitlac-nAg thermosets and PKC α translocated into nuclei. These data confirm that Chitlac-nAg thermosets have a promising utilization in the field of restorative dentistry exerting their antimicrobial activity due to AgNPs without cytotoxicity for eukaryotic cells.This work was supported by grants from MIUR FIRB 2010 and MIUR PRIN-2009.
CircRNA hsa_circ_0110102 Function as Anti-Oncogenic Gene in Hepatocellular Carcinoma Through Modulating miR-580-5p/CCL2 Pathway

Background: Circular RNAs (circRNAs) have been shown to have critical regulatory roles in tumor biology, whereas their contributions in hepatocellular carcinoma (HCC) still remains enigmatic. The purpose of this study was to investigate the molecular mechanisms involved in hsa_circ_0110102 in the occurrence and development of HCC. Methods: The expression levels of hsa_circ_0110102 in HCC cell lines and tissues were estimated by RT-qPCR assay. The proliferation, migration, and invasion of HCC cells were determined by CCK-8 and transwell assay. The western blot and ELISA were employed to examine the related-protein and cytokine expression. The association between miR-580-5p and hsa_circ_0110102 or CCL2 was predicted and affirmed by dual-luciferase reporter assay and RNA pull-down.Results: hsa_circ_0110102 was significantly down-regulated in HCC cell lines and tissues, low hsa_circ_0110102 expression levels were associated with poor prognosis. Knockdown hsa_circ_0110102 significantly inhibited cell proliferation, migration and invasion. In addition, luciferase assay and RNA pull-down assay indicating that hsa_circ_0110102 function as sponge for miR-580-5p. Moreover, miR-580-5p which could directly bind to the 3’-UTR of CCL2 and induce its expression, then active the COX-2/PGE2 pathway in macrophage via FoxO1 in p38 MAPK dependent manner. Furthermore, the Δ256 mutant of FoxO1 showed no activation effect. Conclusion: hsa_circ_0110102 act as a sponge for miR-580-5p and decreased CCL2 secretion in HCC cells, then inhibits pro-inflammatory cytokine release from activated macrophage by regulating the COX-2/PGE2 pathway. These results indicating that hsa_circ_0110102 serves as a potential prognostic predictor or therapeutic target for HCC.
Probing molecular symmetry with polarization-sensitive stimulated Raman spectroscopy

We demonstrate polarization-sensitive stimulated Raman spectroscopy (PS-SRS) enabling fast, high resolution measurement of the depolarization ratio by simultaneous detection of Raman scattered light in orthogonal polarizations. The method provides information about the symmetry of the Raman-active vibrational modes. Our compact PS-SRS setup is based on a tunable continuous wave (CW) probe laser combined with a semi-monolithic nanosecond pulsed pump laser. The CW operation of the laser offers narrow linewidth and low noise, and does not require temporal synchronization with the pump. We demonstrate the technique by measuring the depolarization ratios of carbon-hydrogen (CH) stretches in two different polymer samples in the spectral range of 2825-3025 cm-1. Raman spectra are obtained at a sweep rate of 20 nm/s (84 cm-1/s) with a resolution of 0.65 cm-1. A normalization method is introduced for the direct comparison of the simultaneously acquired polarization Raman spectra.
Progress on Forcing Pulsations for Acoustic, Thermoacoustic or Flow Control Purpose in a Pressurised Vessel by Means of a Siren

A siren is a robust fast-valve that generates effective flow pulsations and powerful noise levels under combustor field conditions. Its principle relies on a sonic jet sheared periodically by a cogged wheel rotating at a given speed. Developed for experiments in combustion stability, it offers an alternative to loudspeakers when the use of these is made difficult because of aggressive flow conditions (e.g. elevated conditions of pressure and temperature, presence of impurities in the gas). While the siren was designed for laboratory applications, its technology is a promising candidate for effective flow control on gas turbine fleets. By scanning through a given frequency range, one detects the acoustic resonance of specific parts of the combustor assembly and identifies a zone of combustion instability during a sensitivity analysis where the flame is exposed to calibrated perturbations. Regarding control applications, it can act out of phase for damping purposes in the low-frequency domain (phase control), or transfer the acoustic energy to a higher and less harmful sub-harmonic (modal control). Since a chocked nozzle is involved, the siren’s actuation is decoupled from the flow condition downstream, which is convenient for control. Following-up to previous works where a siren model was introduced with the capacity to vary the amplitude of pulsation independently from the frequency [GT2011-45071], this paper describes into details new features as follows. First, the performance of the apparatus was improved to visit frequencies in the 0–6 kHz range so that the operation is extended to frequencies met by precessing vortex cores in a burner or tangential instabilities in an annular combustor. Next, the discharge configuration is tested and validated as an alternative to the conventional blow-down operation with the siren placed upstream of the pressurised test cell. There, the siren is placed downstream of the test cell, deriving a small part of the pressurised air in the plenum. Finally, a new calibration procedure for fast pressure probes and accelerometers is presented and tested. A multi-modal excitation is introduced where more than one frequency peak is being produced and where the excited frequencies create a kind of a chord. In conclusion the siren is recommended as an effective flow controller, and as a broadband and powerful calibrator.
Does Corruption Affect Foreign Direct Investment (FDI) Inflows in SADC Countries?

Foreign Direct Investment (FDI) is a crucial factor to development in SADC, while at the same time corruption continues to be an obstacle to economic transformation in these countries. Empirically, studies provide controversial results on the effect of corruption on FDI. Some studies conclude that corruption negatively impacts FDI inflows in a country, while others provide evidence that corruption can act as a ‘helping hand’ to FDI inflows in a country. Given this ambiguity in the results of previous studies, using panel data for the period 2000-2016 for 15 SADC countries, this study examines the impact of corruption on FDI inflows in these countries. Lack of attention in previous studies on the impact of corruption on FDI inflows in SADC motivated this research. Estimation results using robust random effects model show that when corruption is widespread in a country, foreign investors are reluctant to invest. Thus, corruption negatively affects FDI inflows in SADC countries. The study recommends that SADC countries should develop and implement efficient, effective and strong anti-corruption measures to reduce corruption and hence increase FDI inflows.
The Role of Prostaglandin H Synthase (PHS) Bioactivation and Nuclear Factor Erythroid 2-related Factor 2 (Nrf2)-Mediated Protection in Endogenous and Methamphetamine-initiated Neurotoxicity

Endogenous brain compounds and xenobiotics, including the neurotoxins such as the amphetamine analogs 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy), methamphetamine (METH, Speed) and methylenedioxyamphetamine (MDA, active metabolite of MDMA), may be bioactivated by prostaglandin H synthase (PHS) to free radicals that generate reactive oxygen species (ROS). In the absence of adequate antioxidant or repair mechanisms, ROS oxidize macromolecules such as DNA, protein and lipids, which can lead to toxicity. In vitro, we evaluated bioactivation using both purified ovine PHS-1 and cultured cells stably overexpressing either human PHS-1 or hPHS-2 isozymes. We found the neurotransmitter dopamine, its precursors and some metabolites, as well as METH and MDA, can be bioactivated by ovine and/or human PHS in an isozyme-dependent fashion that generates ROS, which oxidize DNA and protein and increase toxicity. This process is blocked by both the PHS inhibitor acetylsalicylic acid (ASA) and the ROS detoxifying enzyme catalase. Our data are the first to reveal isozyme-dependent bioactivation by PHS as a potential mechanism for enhanced susceptibility to both exogenous and endogenous neurotoxins, the latter of which may be particularly important in aging. METH-initiated ROS can also activate redox-sensitive transcription factors such as nuclear factor erythroid 2-related factor 2 (Nrf2), which is involved in the induction of an array of protective mechanisms in both adult and fetal brain. Using Nrf2
Molecular Characterization and Genotypic and Genotypic Evaluation of Antibiotic Resistance of Methicillin Resistant-staphylococcus Aureus Isolated From Raw Meat

Methicillin-resistant Staphylococcus aureus (MRSA) is considered to be one of the most important causes of food-borne diseases. The present investigation was done to assess the phenotypic and genotypic characterization and distribution of Staphylococcal cassette chromosome mec types and Panton–Valentine leukocidin gene in the MRSA strains isolated from raw meat samples. Six-hundred and eighty meat samples were collected and cultured. MRSA strains were subjected to disk diffusion and Polymerase Chain Reaction. One-hundred and thirty-five out of 680 (18.38%) raw meat samples were positive for S. aureus. Seventy-nine out of 125 (63.20%) S. aureus strains were determined as MRSA. Raw sheep meat samples (75%) had the highest prevalence of MRSA, while raw camel had the lowest (50%). Fifty-eight out of 79 (73.41%) MRSA strains harbored the PVL gene. SCCmec IVa (39.65%), V (22.41%) and III (10.34%) were the most commonly detected types in the MRSA strains. MRSA strains harbored the highest prevalence of resistance against penicillin (100%), tetracycline (100%), gentamicin (65.51%) and erythromycin (56.89%). AadA1 (58.62%), tetK (56.89%), msrA (41.37%) and vatA (36.20%) were the most commonly detected antibiotic resistance genes. Simultaneous presence of PVL and antibiotic resistance genes in multi-drug resistant MRSA strains specifies significant public health problem.
The Effect of Valence of eWOM Amongst Online Information Sources on Consumer’s Purchase Intentions

Seeking information about a product has always remained the most important element before purchase a product. The drive behind this study is to look in detail at the mediums where consumers land up to seek information about a product on the World Wide Web. The most common sources a consumer can look into are: electronic word-of mouth, expert opinion-based websites (neutral groups), and manufacturer’s website. The study will also look into how these sources influence consumer’s purchase intentions and their responsiveness to get influenced by information provided through these mediums. The positive and negative valences of comments when talking about social media marketing has provided an unmatched mode for consumers to disclose their experiences and evaluations of the products they consume hence fostering an effective word of mouth. This study is also focusing on studying the patterns that influence the positive and negative valence of comments in electronic word-of-mouth that will show the effect on consumer purchase intentions. For the purpose of this study questionnaires were filled online by 150 respondents. Their answers were then analyzed for this research using smart plus as a tool. The results have helped us analyze how online sources of information produced on a variety of forums creates an impact on consumer’s purchases.
Russia’s Covid – 19 Vaccine: Social discussion and first emotions

Social media chats related to healthcare are the prodigious basis of analysing the emotions of the people. Now, the Covid-19 vaccine is being the prevalent hope of nearly the entire mankind in the planet. Russia’s first vaccine announcement kindled the various rays of emotions among the social media users which are shared as tweets. The tweet data is collected and analysed for the emotions and psychology of the users along with the topic of interest in their discussion. Using computational methods and algorithms such as machine learning and LDA, the social emotions are revealed and presented.
Aplicação do Algoritmo de Levenberg Marquardt para Modelagem na Alocação de Potência para Usuários LTE na Faixa de 3.5 GHz com Diferentes CQI

Using the Levenberg-Marquardt (LM) algorithm for parameter estimation, we present in this article sigmoidal-like utility functions that model the probability of success in the transmission of packets per unit of power consumed by a user. Simulation is proposed in network mobile for users located under the coverage area of the small cells, with the 3.5 GHz band and with different modulation and coding schemes (MCS) standardized in 3rd Generation Partnership Project (3GPP). Resumo. Utilizando o algoritmo de Levenberg-Marquardt (LM) para estimação de parâmetros, apresentamos neste artigo as funções de utilidade sigmoidal que modelam a probabilidade de sucesso por unidade de potência consumida por um usuário. A simulação é proposta em redes móveis para os usuários localizados sob a área de cobertura das pequenas células, com uma faixa de 3,5 GHz e com diferentes Esquemas de Modulação e Codificação (MCS Modulation and Coding Schemes) padronizados no Projeto de Parceria de Terceira Geração (3GPP 3rd Generation Partnership Project).
PENGARUH KUALITAS PRODUK, KUALITAS LAYANAN DAN CITRA MEREK TERHADAP NIAT PEMBELIAN ULANG

Terjadinya fluktuasi penjualan sepeda motor pada Dealer Astra Motor Center Denpasar membuat Honda harus bekerja lebih keras untuk meningkatkan kembali jumlah penjualan produknya. Dengan niat pembelian ulang diharapkan dapat meningkatkan jumlah penjualan produknya. Tujuan penelitian ini adalah untuk menjelaskan pengaruh kualitas produk, kualitas layanan dan citra merek terhadap niat pembelian ulang pada Dealer Astra Motor Center Denpasar. Penelitian ini dilakukan di Dealer Astra Motor Center Denpasar, dengan jumlah responden sebanyak 126. Pengambilan sampel ini menggunakan metode purposive sampling. Teknik analisis yang digunakan adalah analisis regresi berganda dengan Statitical Package of Sosial Science (SPSS) 17.0. Hasil penelitian menunjukkan kualitas produk, kualitas pelayanan dan citra merek berpengaruh positif dan signifikan terhadap niat pembelian ulang sepeda motor merk Honda di Kota Denpasar. Kata kunci : niat pembelian ulang; kualitas produk; kualitas layanan dan citra merek
Analogue spin–orbit torque device for artificial-neural-network-based associative memory operation

We demonstrate associative memory operations reminiscent of the brain using nonvolatile spintronics devices. Antiferromagnet–ferromagnet bilayer-based Hall devices, which show analogue-like spin–orbit torque switching under zero magnetic fields and behave as artificial synapses, are used. An artificial neural network is used to associate memorized patterns from their noisy versions. We develop a network consisting of a field-programmable gate array and 36 spin–orbit torque devices. An effect of learning on associative memory operations is successfully confirmed for several 3 × 3-block patterns. A discussion on the present approach for realizing spintronics-based artificial intelligence is given.
A Multi-Level Analysis of the Implementation of Industrial Internet of Things: Challenges and Future Prospects

Industrial Internet of Things (IIoT) is still a new research area. The main emphasis of the IIoT literature is on identifying the challenges involved in implementation of the IIoT. This paper summarizes the literature on the barriers faced by any stakeholder aiming to adopt IIoT anywhere. After reviewing 31 empirical studies, three domains of factors have been identified, individual (skills, abilities and knowledge), institutional (organizational/management-related), and structural (technical and economic infrastructures). A total of eleven factors across the three dimensions have been extracted. The most important factors were the absence of human capital (limited individual soft and technical knowledge, skills and abilities), low information security experience leading to a high probability data leaks and high management resistance from employees and leaders. To strengthen information for successful IIoT implementation, this paper proposes the mandate of Security, Education, Training, and Awareness (SETA) initiatives for any stakeholder interested in IIoT adoption. A Causal loop diagram for the IIoT implementation is also developed and discussed in this work.
Blockchain y arbitraje: un nuevo enfoque en la resolución de disputas. Especial énfasis en smartcontracts y criptodivisas

Las nuevas tecnologías han revolucionado el mundo de los negocios y servicios. Sin embargo, las transacciones efectuadas mediante o con el auxilio de estas tecnologías no están exentas de problemas. Este artículo aborda el funcionamiento de la blockchain, una de las tecnologías que, pese a tener un futuro incierto, desde hace tiempo se viene aplicando. La blockchain, según estimaciones, transformará la forma en que se realizan transacciones e incidirá, notoriamente, tanto en la modalidad de prestación de servicios profesionales como en la resolución de controversias. En este trabajo se trata su vínculo con el arbitraje en cuanto método de resolución de controversias más adecuado a tales efectos, con especial énfasis en aquellos aspectos prácticos que podrían dar lugar a conflictos para cuya solución no hay un marco regulatorio establecido.
Crizotinib versus alectinib for treatment of ALK-positive non-small cell lung cancer: a pooled analysis of the ALEX, ALESIA and J-ALEX clinical trials

Background: Crizotinib and alectinib were the two most commonly used anaplastic lymphoma kinase (ALK) inhibitors for ALK-positive non-small cell lung cancer (NSCLC). We compared their antitumor efficacies and adverse effects based on a pooled analysis of the ALEX, ALESIA and J-ALEX clinical trials.Methods: Seven databases were searched for eligible articles. The primary endpoints included overall survival (OS), progression-free survival (PFS), central nervous system (CNS)-PFS, drug responses and adverse effects (AEs). Results: Three randomized controlled clinical trials (ALEX, ALESIA and J-ALEX) with a total of 7 articles and 697 patients were included. Compared with crizotinib, alectinib exhibited superior efficacy in PFS (HR [hazard ratio]: 0.35, [0.25-0.49], p < 0.00001), OS (HR: 0.66, [0.47-0.92], p = 0.02), CNS-PFS (HR: 0.17, [0.11-0.24], p < 0.00001), duration of response (HR: 0.31, [0.23-0.42], p < 0.00001), objective response rate (ORR) (Risk ratio [RR]: 0.87, [0.80-0.94], p = 0.0003), partial response (PR) (RR: 0.88, [0.81-0.96], p = 0.004), and grade 3-5 AEs (RR: 1.43, [1.09-1.87], p = 0.009). Additionally, the survival advantages of alectinib compared with crizotinib increased with alectinib’s prolongation of survival time. The disease control rate, complete response and total AEs were comparable between the two groups. A greater increase in constipation, nausea, diarrhea, alanine aminotransferase, vomiting, aspartate aminotransferase, peripheral edema, dysgeusia, and visual impairment as well as a greater decrease in appetite and neutrophil count were associated with the crizotinib groupConclusions: In both antitumor efficacy and safety, alectinib appears to be superior to crizotinib for the treatment of ALK-positive NSCLC.
AN OT ACCOUNT OF PHONOTACTIC AND CODA NEUTRALIZATION OF ENGLISH LOANS IN PILIBHIT HINDI-URDU

This paper provided the basic information of the phonological processes as the Coda Neutralization and Phonotactics of English Loans in Pilibhit Hindi-Urdu within the framework of Optimality Theory (OT). The objectives of this paper were to represent the aspects of the coda neutralization in the sense of voiced obstruent segment becomes voiceless obstruent segment in the final syllable structure of the loanwords, and the consonant clusters break within the insertion of an extraneous segment in any location of the English Loans in Pilibhit Hindi-Urdu. In the another framework, this paper revealed the phenomena of devoicing features of coda consonants and the grades of the additional segments in Pilibhit Hindi-Urdu loanwords within the principles of Optimality Theory (Prince & Smolensky, 1993). The central idea of this paper was to explore the process of conflicts between the candidates at the surface level and reflects the properties of the input candidate by the observation of the constraint rankings. In this study, it was propounded the effective formalities of the hierarchy of the constraint rankings and drew one of the best candidates as an optimal candidate out of the output candidates from English loans in Pilibhit Hindi-Urdu. The groundwork of this paper was related to the significant aspects of the English loans that were adapted within the addition, insertion, or deletion of the segments in Pilibhit Hindi-Urdu. In this paper, it was also determined the facts of the coda devoicing of the speech segments in terms of neutralization at the end of the syllable structure of English loans in Pilibhit Hindi-Urdu.