Miracle-dz/UniFAR-FTUs huggingface dataset:
In Vitro Cross-Resistance Profile of Nucleoside Reverse Transcriptase Inhibitor (NRTI) BMS-986001 against Known NRTI Resistance Mutations

ABSTRACT BMS-986001 is a novel HIV nucleoside reverse transcriptase inhibitor (NRTI). To date, little is known about its resistance profile. In order to examine the cross-resistance profile of BMS-986001 to NRTI mutations, a replicating virus system was used to examine specific amino acid mutations known to confer resistance to various NRTIs. In addition, reverse transcriptases from 19 clinical isolates with various NRTI mutations were examined in the Monogram PhenoSense HIV assay. In the site-directed mutagenesis studies, a virus containing a K65R substitution exhibited a 0.4-fold change in 50% effective concentration (EC50) versus the wild type, while the majority of viruses with the Q151M constellation (without M184V) exhibited changes in EC50 versus wild type of 0.23- to 0.48-fold. Susceptibility to BMS-986001 was also maintained in an L74V-containing virus (0.7-fold change), while an M184V-only-containing virus induced a 2- to 3-fold decrease in susceptibility. Increasing numbers of thymidine analog mutation pattern 1 (TAM-1) pathway mutations correlated with decreases in susceptibility to BMS-986001, while viruses with TAM-2 pathway mutations exhibited a 5- to 8-fold decrease in susceptibility, regardless of the number of TAMs. A 22-fold decrease in susceptibility to BMS-986001 was observed in a site-directed mutant containing the T69 insertion complex. Common non-NRTI (NNRTI) mutations had little impact on susceptibility to BMS-986001. The results from the site-directed mutants correlated well with the more complicated genotypes found in NRTI-resistant clinical isolates. Data from clinical studies are needed to determine the clinically relevant resistance cutoff values for BMS-986001.
Distributed Secondary Voltage and Frequency Restoration Control of Droop-Controlled Inverter-Based Microgrids

In this paper, restorations for both voltage and frequency in the droop-controlled inverter-based islanded microgrid (MG) are addressed. A distributed finite-time control approach is used in the voltage restoration which enables the voltages at all the distributed generations (DGs) to converge to the reference value in finite time, and thus, the voltage and frequency control design can be separated. Then, a consensus-based distributed frequency control is proposed for frequency restoration, subject to certain control input constraints. Our control strategies are implemented on the local DGs, and thus, no central controller is required in contrast to existing control schemes proposed so far. By allowing these controllers to communicate with their neighboring controllers, the proposed control strategy can restore both voltage and frequency to their respective reference values while having accurate real power sharing, under a sufficient local stability condition established. An islanded MG test system consisting of four DGs is built in MATLAB to illustrate our design approach, and the results validate our proposed control strategy.
Clavicle fracture management: A comparison of a tertiary hospital and rural telehealth sites

The clavicle is one of the most commonly fractured bones in the adult population. Management has traditionally been conservative, however more recent research has yielded higher non-union rates associated with non-operative management. This study aims to analyse the proportion of operative and non-operative treatment methods for clavicle fracture in a tertiary hospital facility and rural health sites accessed via telehealth, comparing patient outcome between these two methods of fracture management. Following ethical approval, a retrospective review was conducted of patients presenting with clavicle fractures to the Princess Alexandra Hospital Fracture Clinics and to Orthopaedic Fracture Clinics run via teleconference with rural health sites. Only 2% of patients received operative fracture management in the telehealth group, versus 33% in the tertiary hospital sample. Patient outcome was measured in the larger tertiary hospital sample, with clinical notes reflecting good patient outcome in 70% of operatively managed patients and 85% of patients with conservatively managed clavicle fractures. For the patients in the telehealth sample that returned for follow-up appointments, 93% reported a good outcome with one of these individuals undergoing operative treatment and the rest managed conservatively.
EXPERIENCE AND REVIEW OF SARS CONTROL IN VIETNAM AND CHINA

Severe Acute Respiratory Syndrome (SARS) has rapidly spread and caused epidemics in many countries. During these epidemics, the Japanese government contributed to SARS control by dispatching medical teams. In the present article, the author reviews and discusses the process of control of the SARS outbreak based on experiences in activities to support SARS control in Vietnam and China.Vietnam succeeded in the effective control of SARS for the first time in the world. This was accomplished by complete isolation of patients and implementation of nosocomial infection control from an early stage of epidemic, etc. In China, due to inadequate response in the early stage, nosocomial infection occurred frequently and the disease quickly spread. However, later, effective actions were taken under the strong direction of the government, and the disease was finally put under control. The Japan Medical Team for Disaster Relief dispatched by the government of Japan to Hanoi, Vietnam and Beijing, China offered cooperative activities for the prevention of nosocomial infection and respiratory management. In addition, the Medical Aid Team sent to Guangdong Province in China provided guidance to the local Japanese residents to prevent the infection of SARS and to alleviate anxiety about the disease. In the control of SARS, it is essential to take adequate actions from an early stage in the development of the disease. For this purpose, rather than starting measures for the control of nosocomial infection after the eruption of the disease, it is important to train medical staff on a routine basis, to establish a nosocomial infection control system, and to consolidate basic preventive practices.
Irbesartan attenuates Ang II-induced BMP-2 expression in human umbilical vein endothelial cells

Abstract Bone morphogenetic protein-2 (BMP-2), a transforming growth factor-β superfamily member cytokine, plays a key role both in vascular development and in pathophysiological processes. However, the effects and mechanisms of angiotensin II (Ang II) on BMP-2 expression remain unknown in human umbilical vein endothelial cells (HUVECs). Here we show that Ang II treatment significantly increased BMP-2 expression, associated with NF-κB activation, which was suppressed by treatment with pyrrolidine dithiocarbamate (PDTC) or irbesartan. Furthermore, the increased levels of MDA (malondialdehyde) in conditioned media and the decrease in activities of total superoxide dismutases (SOD) caused by Ang II were reversed by irbesartan or PDTC treatment. Our findings indicate that Ang II-induced BMP-2 expression might contribute to NF-κB activation. BMP-2 expression induced by Ang II might involve excessive oxidative stress.
The Special Challenges of Ecommerce in China: A Preliminary Investigation of Sufficient Conditions for Generating Adequate Consumer Trust for Initial Launch

The ecommerce market in China is both the largest online market in the world and the one with the greatest number of low quality or counterfeit product offerings. Using case studies to develop testable hypotheses, as proposed by Eisenhardt and Graebner, we examine three very successful online companies in China and their very different paths to success. Our findings suggest that offering promises, assurances, and guarantees to consumers is not sufficient, because it is relatively easy for low quality sellers to offer counterfeit promises along with counterfeit products. We do find that promises backed up reputational capital can be sufficient to generate necessary online trust, and that actions must be taken to maintain quality in order to maintain trust. We understand the limitations of the work: since the same dataset cannot be used both to generate hypotheses and to test them we view this work as theory generation and not theory testing.
Treatment of renal artery in-stent restenosis with sirolimus-eluting stents

The objective of this study was to analyze the use of sirolimus-eluting stent (SES) placement for the treatment of renal artery in-stent restenosis (RA-ISR). The optimal treatment of RA-ISR has not been fully elucidated to date. We retrospectively analyzed consecutive patients from our institution who underwent treatment of RA-ISR with a SES from May 2004 to June 2006. Using duplex ultrasound, RA-ISR (> 60% diameter) was determined by peak systolic velocity (PSV) > 300 cm/s and renal aortic ratio (RAR) > 4.0. Renal function (creatinine) and blood pressure were measured at baseline and follow-up. SESs were implanted in 16 patients (22 renal arteries) during the study period. The study cohort was predominantly female (75%) with a mean age of 68 ± 12 years. RA-ISR was treated with SESs with a mean diameter of 3.5 mm and mean length of 17.9 ± 3.8 mm. The mean post-dilation balloon diameter was 4.8 ± 0.6. The baseline renal artery PSV was 445 ± 131 cm/s with a mean RAR of 5.0 ± 1.6. Follow-up information was available in 21 renal arteries. During a median follow-up of 12 months (range: 9—15 months), 15 renal arteries (71.4%) developed recurrence of ISR by ultrasonographic criteria. Univariate analysis revealed that female sex was an independent predictor of recurrence of ISR after SES implantation (p < 0.05). In conclusion, placement of a SES for the treatment of ISR in renal arteries is associated with high initial technical success but significant restenosis on duplex ultrasonography at follow-up.
Hybrid Capture™ Method for Detection of Human Papillomavirus DNA in Clinical Specimens: A Tool for Clinical Management of Equivocal Pap Smears and for Population Screening

and Key Words High- and intermediate-risk types of human papillomavirus (HPV) in concert with cofactors are responsible for over 90% of cervical cancers world-wide. While the Pap smear is a valuable cancer prevention tool, its subjective nature leaves it error prone. As a result, HPV DNA testing appears to be a needed adjunct to the Pap smear. Hybrid Capture is a simple DNA test with high specificity and sensitivity which appears useful for clinical management of equivocal Pap tests and shows promise for mass screening.
Arterial dysfunction and functional performance in patients with peripheral artery disease: A review

Functional performance influences quality of life in individuals with peripheral artery disease (PAD) and is also a powerful prognostic marker in these patients. The pathophysiology of impaired functional performance in patients with PAD is incompletely understood. The severity of atherosclerotic burden, non-invasively assessed by the ankle—brachial index (ABI), does not reliably predict the degree of functional impairment observed in PAD patients. We review associations of measures of arterial function (arterial stiffness and endothelial dysfunction) with functional performance in PAD patients, and also review potential therapies for arterial stiffness and endothelial dysfunction that could improve functional performance in PAD. Recent studies suggest that measures of arterial function, such as arterial stiffness and endothelial function, are associated with exercise performance in the setting of PAD. These studies have provided new insights into (1) the pathophysiology of functional impairment in PAD, (2) mechanisms of strategies known to be effective such as walking programs, and (3) potential new therapeutic interventions for improving functional performance. Thus, therapies aimed at arterial ‘de-stiffening’ and improving endothelial function (such as aerobic exercise, statins and angiotensin-converting enzyme inhibitors) may improve functional performance in patients with PAD; however, further investigations are needed.
Multiphase machines and drives - Revisited

Although the concept of a multiphase drive system dates back to the middle of the 20th century, the initial pace of development was rather slow, as witnessed by the first two surveys of the area published in the beginning of this century. However, considerably new developments have resulted in the last decade of the 20th century and the beginning of this century, leading to an authoritative survey of the asymmetrical six-phase drive control and subsequently of the review of the complete area. This also initiated the organization and subsequent publication of the first IEEE Transactions on Industrial Electronics "Special Section on Multiphase Machines and Drives" in May 2008, which commenced with another survey paper, and that contained 12 original research papers. Since the publication of this Special Section in May 2008, the level of interest and pace of developments in the area have further accelerated and substantial new knowledge has been generatedwith an ever-increasing number of published research papers and reported new industrial applications. Such a trend has been emphasized in a recent paper. It therefore seemed appropriate to revisit the area and organize this Special Section as a sequel to the first one. The call for the Special Section papers resulted in 51 submissions, almost twice as many as the total back in 2008, thus confirming a substantial growth of the area. Indeed, the amount of new knowledge acquired since the publication of the first Special Section in 2008 has meant that it was not possible to provide a complete and thorough survey of the field in a single review paper.
Introduction to Electronic Government Education, Training and Professionalization Minitrack

This paper introduces the objectives and content of the minitrack on Electronic Government Education, Training and Professionalization, organized as part of the Electronic Government Track at the 46th Hawaii International Conference on System Sciences, 7-10 January 2013, Hawaii, USA. After explaining the rationale, scope and topics of the minitrack, the paper presents the summaries of all accepted papers.
Shared Domain Knowledge in Strategic Green IS Alignment: An Analysis from the Knowledge-Based View

In this paper, we argue that the inclusion of environmental sustainability aspects increases the complexity of Information Systems (IS) alignment. The business value of IS and their potential to render firms more sustainable can only be leveraged if IS are strategically aligned. The literature from relevant academic disciplines is reviewed to lay a theoretical foundation. We define the term Green IS strategy, introduce a strategy typology, and integrate environmental aspects into Green IS alignment. The alignment process is determined by social aspects that are analyzed from the knowledge-based perspective in this research. We find that sharing of knowledge between the domains of business, IS, and sustainability is a premise for Green IS alignment. In this context, the importance of internally transferring tacit knowledge between different organizational actors on corporate, competitive and functional level is emphasized. Finally, we discuss implications for research and practice and make recommendations for further research.
Methicillin-Resistant and -Susceptible Staphylococcus aureus Strains of Clonal Lineages ST398 and ST9 from Swine Carry the Multidrug Resistance Gene cfr

ABSTRACT Methicillin-resistant Staphylococcus aureus clonal lineage ST398 and methicillin-susceptible lineage ST9 strains have their main reservoir in swine but can colonize and cause infections in humans. The phenicol/lincosamide/oxazolidinone/pleuromutilin/streptogramin A multidrug resistance gene cfr was detected in isolates of both clonal lineages, rendering a spread to humans with exposure to swine farming possible.
High β-Lactamase Levels Change the Pharmacodynamics of β-Lactam Antibiotics in Pseudomonas aeruginosa Biofilms

ABSTRACT Resistance to β-lactam antibiotics is a frequent problem in Pseudomonas aeruginosa lung infection of cystic fibrosis (CF) patients. This resistance is mainly due to the hyperproduction of chromosomally encoded β-lactamase and biofilm formation. The purpose of this study was to investigate the role of β-lactamase in the pharmacokinetics (PK) and pharmacodynamics (PD) of ceftazidime and imipenem on P. aeruginosa biofilms. P. aeruginosa PAO1 and its corresponding β-lactamase-overproducing mutant, PAΔDDh2Dh3, were used in this study. Biofilms of these two strains in flow chambers, microtiter plates, and on alginate beads were treated with different concentrations of ceftazidime and imipenem. The kinetics of antibiotics on the biofilms was investigated in vitro by time-kill methods. Time-dependent killing of ceftazidime was observed in PAO1 biofilms, but concentration-dependent killing activity of ceftazidime was observed for β-lactamase-overproducing biofilms of P. aeruginosa in all three models. Ceftazidime showed time-dependent killing on planktonic PAO1 and PAΔDDh2Dh3. This difference is probably due to the special distribution and accumulation in the biofilm matrix of β-lactamase, which can hydrolyze the β-lactam antibiotics. The PK/PD indices of the AUC/MBIC and Cmax/MBIC (AUC is the area under concentration-time curve, MBIC is the minimal biofilm-inhibitory concentration, and Cmax is the maximum concentration of drug in serum) are probably the best parameters to describe the effect of ceftazidime in β-lactamase-overproducing P. aeruginosa biofilms. Meanwhile, imipenem showed time-dependent killing on both PAO1 and PAΔDDh2Dh3 biofilms. An inoculum effect of β-lactams was found for both planktonic and biofilm P. aeruginosa cells. The inoculum effect of ceftazidime for the β-lactamase-overproducing mutant PAΔDDh2Dh3 biofilms was more obvious than for PAO1 biofilms, with a requirement of higher antibiotic concentration and a longer period of treatment.
Genomic and Functional Portrait of a Highly Virulent, CTX-M-15-Producing H30-Rx Subclone of Escherichia coli Sequence Type 131

ABSTRACT Escherichia coli sequence type 131 (ST131) is a pandemic clone associated with multidrug-resistant, extraintestinal infections, attributable to the presence of the CTX-M-15 extended-spectrum β-lactamase gene and mutations entailing fluoroquinolone resistance. Studies on subclones within E. coli ST131 are critically required for targeting and implementation of successful control efforts. Our study comprehensively analyzed the genomic and functional attributes of the H30-Rx subclonal strains NA097 and NA114, belonging to the ST131 lineage. We carried out whole-genome sequencing, comparative analysis, phenotypic virulence assays, and profiling of the antibacterial responses of THP1 cells infected with these subclones. Phylogenomic analysis suggested that the strains were clonal in nature and confined entirely to a single clade. Comparative genomic analysis revealed that the virulence and resistance repertoires were comparable among the H30-Rx ST131 strains except for the commensal ST131 strain SE15. Similarly, seven phage-specific regions were found to be strongly associated with the H30-Rx strains but were largely absent in the genome of SE15. Phenotypic analysis confirmed the virulence and resistance similarities between the two strains. However, NA097 was found to be more robust than NA114 in terms of virulence gene carriage (dra operon), invasion ability (P < 0.05), and antimicrobial resistance (streptomycin resistance). RT2 gene expression profiling revealed generic upregulation of key proinflammatory responses in THP1 cells, irrespective of ST131 lineage status. In conclusion, our study provides comprehensive, genome-inferred insights into the biology and immunological properties of ST131 strains and suggests clonal diversification of genomic and phenotypic features within the H30-Rx subclone of E. coli ST131.
Large-Scale Web Page Classification

This research investigates the design of a unified framework for the content-based classification of highly imbalanced hierarchical datasets, such as web directories. In an imbalanced dataset, the prior probability distribution of a category indicates the presence or absence of class imbalance. This may include the lack of positive training instances (rarity) or an overabundance of positive instances. We partitioned the subcategories of the Yahoo! web directory into five mutually exclusive groups based on the prior probability distribution. The best performing classification methods for a particular prior probability distribution were identified and used to design a content-based classification model for the complete (as of 2007) Yahoo! web directory of 639,671 categories and 4,140,629 web pages. The methodology was validated using a DMOZ subset of 17,217 categories and 130,594 web pages and we demonstrated statistically that the methodology of this research works equally well on large and small datasets.
Fertility treatment in women with premature ovarian failure

Premature ovarian failure (POF) is defined as ovarian failure and early menopause before the age of 40 years. This POF occurs in 1% of women younger than 40 and up to 0.1% women younger than 30, and may have different etiologic causes, such as genetic, autoimmune, iatrogenic, toxic, enzymatic, infectious and metabolic. The etiologic cause can be diagnosed in less than half of the cases. Signs of intermittent ovarian function in karyotypically normal women have been described, but predicting the probability of spontaneous remission in a specific woman is impossible. The possible beneficial effect of treatments such as immunosuppressive therapies, gonadotropin-releasing hormone (GnRH) agonists, exogenous high-dose gonadotropins and estrogen replacement, published in numerous anecdotal case reports, is unclear, and the cause–effect relationship has not been proven by prospective randomized studies. Therefore, in order to find effective treatments, basic pathophysiologic mechanisms must be better understood.
Examining the Social Influence on Information Technology Sustained Use in a Community Health System: A Hierarchical Bayesian Learning Method Analysis

This paper develops a hierarchical Bayesian learning model to investigate the social influence on sustained use of technology in healthcare. First, this post-adoption Bayesian learning model study makes a contribution to the limited literature on sustained technology use. Second, in the post-adoption stage, our sustained use Bayesian learning model shows that the difference between peer effects and opinion leader effects are not significant. This finding differs from those found in the existing literature examining social influence on technology adoption. This phenomenon reveals the technology user's psychological changes in response to social influence at different stages of technology adoption and use. Therefore, this brings up a practical policy implication regarding how to leverage this change and what type of social influence should be considered to leverage during the technology implementation stage, for promoting early adoption or for encouraging sustained use.
Evaluation of Sulfobutylether-β-Cyclodextrin Exposure in a Critically Ill Patient Receiving Intravenous Posaconazole While Undergoing Continuous Venovenous Hemofiltration

ABSTRACT We present a 31-year-old female who had undergone an allogeneic bone marrow transplantation and who was started on intravenous posaconazole for pulmonary mycosis while undergoing continuous venovenous hemofiltration (CVVH). We performed steady-state pharmacokinetic evaluations for both posaconazole and sulfobutylether-β-cyclodextrin (SBECD). SBECD was effectively removed by CVVH, with observed exposure similar to that for patients with moderate renal impairment. Intravenous posaconazole at standard doses may be utilized in critically ill patients undergoing CVVH without significant risk of SBECD accumulation.