Miracle-dz/UniFAR-FTUs huggingface dataset:
TREATMENT OF ANGINA PECTORIS WITH DIPYRIDAMOLE: A DOUBLE‐BLIND STUDY

In a double‐blind study, 48 patients (age range, 47 to 75) with angina pectoris received either dipyridamole (Persantine) (200 mg daily) or placebo for an average of five months. Nitroglycerin was taken sublingually as required for relief of acute attacks. Previous use of long‐acting nitrates had produced no significant improvement.
The genomic landscape of Neanderthal ancestry in present-day humans.

, Abstract Analyses of Neandertal genomes have revealed that Neandertals have contributed genetic variants to modern humans 1–2 . The antiquity of Neandertal gene flow into modern humans means that regions that derive from Neandertals in any one human today are usually less than a hundred kilobases in size. However, Neandertal haplotypes are also distinctive enough that several studies have been able to detect Neandertal ancestry at specific loci 1,3–8 . Here, we have systematically inferred Neandertal haplotypes in the genomes of 1,004 present-day humans 12 . Regions that harbor a high frequency of Neandertal alleles in modern humans are enriched for genes affecting keratin filaments suggesting that Neandertal alleles may have helped modern humans adapt to non-African environments. Neandertal alleles also continue to shape human biology, as we identify multiple Neandertal-derived alleles that confer risk for disease. We also identify regions of millions of base pairs that are nearly devoid of Neandertal ancestry and enriched in genes, implying selection to remove genetic material derived from Neandertals. Neandertal ancestry is significantly reduced in genes specifically expressed in testis, and there is an approximately 5-fold reduction of Neandertal ancestry on chromosome X, which is known to harbor a disproportionate fraction of male hybrid sterility genes 20–22 . These results suggest that part of the reduction in Neandertal ancestry near genes is due to Neandertal alleles that reduced fertility in males when moved to a modern human genetic background.
Insights into Gate-Underlap Design in FinFETs for Ultra-Low Voltage Analog Performance

In this work, the usefulness of gate-underlap design to overcome the degradation of analog/rf FOMs (figures of merit) has been analyzed for ULV applications. For a device designed with d=5 nm/dec, the spacer widths in the range or 20- 50 nm represents lateral straggle values in the desired range of 10-15 nm independent of gate length to achieve significant improvement in analog FOMs. The optimal values of spacer widths range from 0.8Lg for 60 nm FinFETs to ~1.7Lg for 30 nm devices and even higher spacer-to-gate length ratios for 20 nm devices. The present work provides new opportunities for realizing future ULV analog/rf circuits.
Scattering power decomposition and its applications

Extraction of polarimetric information from SAR data is one of the most important issues in SAR applications. Since fully polarimetric SAR data and model-based scattering power decomposition are now available, its real utilization becomes important topic. In this presentation, some data sets from PiSAR-L2, ALOS, ALOS-2 systems are shown using the existing model-based scattering power decompositions. The observation areas are chosen so that each scattering mechanism correspond specific scattering power utilization, i.e., landslide area for the surface scattering, urban expansion for the double bounce scattering, deforestation for the volume scattering. The final color-coded images provide us with direct way to understand the scattering scenario in the real world.
Indications of gentle forest land grabbing in Latvia

The term land grabbing in scientific literature has been used since approximately 2007 2008 to describe a trend of large scale land transactions (deals, acquisitions etc.) in rural areas made mostly by foreign companies or multinational corporations as well as governments. In many places worldwide, such transactions have reached large-scale proportions. There are several similar characteristics that explain what exactly is ‘land grabbing’, its causes and its consequences. The purpose of this research is to identify the trend of land grabbing in general and then to determine whether land grabbing characteristics are found in Latvia. Specifically, this research is focused on the data analysis of forest land owned by foreigners who own a minimum 500 hectares in at least one region of Latvia.
Differences in the responses of the pituitary beta-endorphin and cardiovascular system to ethanol and stress as a function of family history.

BACKGROUND Genetic and environmental factors, such as stress, are important for the initiation and maintenance of heavy drinking, whereas beta-endorphin may be important in controlling alcohol consumption. These studies investigated the response of pituitary beta-endorphin to stress and the effect of alcohol on the stress response in subjects at low (LR) and high (HR) risk of alcoholism, as determined from their family history. METHODS Twenty LR and 20 HR subjects were exposed to stress 30 min after ingestion of either a placebo or an alcohol drink. Plasma beta-endorphin was measured before and for 4 hr after the drink. Changes in the concentration of plasma beta-endorphin after ingestion of the placebo or alcohol drink alone served as controls to compare the stress-induced changes. Pulse and diastolic and systolic blood pressure were also measured. RESULTS HR subjects presented higher baseline values of pulse and systolic blood pressure and lower plasma beta-endorphin than LR subjects. Stress induced a small increase in cardiovascular activity, whereas alcohol induced a stronger stimulation. Alcohol before stress did not prevent the stress-induced increase in cardiovascular activity. Stress, but not alcohol, increased the plasma beta-endorphin concentration. LR subjects presented a higher stress-induced increase in plasma beta-endorphin and a faster recovery than HR subjects. Alcohol before stress attenuated the stress-induced increase in plasma beta-endorphin in both LR and HR subjects. This attenuation was stronger in LR subjects. CONCLUSIONS Thus, there are differences in the response of beta-endorphin to stress and the effect of ethanol on stress responses as a function of a family history of alcoholism.
The Application and Practice of Parallel Cloud Computing in ISP

In order to deal with massive data processing, China Telecom has deployed a platform named distributed service engine, which is based on parallel cloud computing technology. On this platform, we also developed some tele-data processing system and internet applications to show the effectiveness of this platform. This paper describes the design of this platform and how it can be used in telecom industry.
Cell phone-based health education messaging improves health literacy.

BACKGROUND The ubiquity of cell phones, which allow for short message service (SMS), provides new and innovative opportunities for disease prevention and health education. OBJECTIVE To explore the use of cell phone-based health education SMS to improve the health literacy of community residents in China. METHODS A multi-stage random sampling method was used to select representative study communities and participants ≥ 18 years old. Intervention participants were sent health education SMSs once a week for 1 year and controls were sent conventional, basic health education measures. Health literacy levels of the residents before and after the intervention were evaluated between intervention and control groups. RESULTS Public health literacy scores increased 1.5 points, from 61.8 to 63.3, after SMS intervention for 1 year (P<0.01); the increase was greater for males than females (2.01 vs. 1.03; P<0.01) and for Shenzhen local residents than non-permanent residents (2.56 vs. 1.14; P<0.01). The frequency of high health literacy scores was greater for the intervention than control group (22.03% to 30.93% vs. 22.07% to 20.82%). With health literacy as a cost-effective index, the cost-effectiveness per intervention was 0.54. CONCLUSION SMS may be a useful tool for improving health literacy.
Platform business models

This article presents the results of comparative analysis of platform business models based on a unique typology of platforms and proposed parameters of business models. It was concluded that in order to describe a platform business model, it is possible to use a series of parameters specific to business models of traditional non-platform companies, extending their contents. However, the specific character of platforms requires setting/introducing a new business model parameter, which will reflect an innovative component, and detailed analysis of possible solutions to a dilemma of monetization of value created by platforms without destroying the network effect.
Interactive lectures using quick response codes

This presentation will describe an ongoing project to encourage student interaction during lectures through the use of quick response (QR) codes and Google forms to generate rapid response polls and quizzes. The use of Google apps software and the students' own mobile phone presents a free alternative to the current clicker systems. The overall process from the creation of the software to the roll out and use of the software in an interactive lecture, the issues encountered and participant feedback will also be described.
Extracorporeal Shock Wave Therapy for Treatment of Navicular Syndrome

Extracorporeal shock wave therapy was effective in decreasing the lameness associated with navicular syndrome in 81% of the horses as determined by an unmasked evaluator and in 56% of the horses with masked evaluators. Extracorporeal shock wave therapy provided a non-invasive, effective mechanism to decrease the lameness associated with navicular syndrome. There were no complications associated with the procedure. Horses that responded to treatment did not regress in the year after treatment. Authors' addresses: Department of Veterinary Clinical Sciences, (McClure,
Mnesic Imbalance or Hyperthymestic Syndrome as Cause of Autism Symptoms in Shereshevskii

Solomon Veniaminovich Shereshevskii (1886-1958) was a man studied by psychologist Aleksandr Romanovich Luria, who thought that Shereshevskii’s (S) remarkable memory caused a psychological syndrome with cognitive deficits; consequently, Luria not only described S’s memory, but also other aspects of his life such as his synaesthesia, mental imagery, preferences, strengths, weaknesses and personality [1]. Likewise, more recently the phrase “hyperthymestic syndrome” (hyperthymesia) has been coined in order to de‐ scribe the case of a woman (AJ) whose autobiographical memory is extraordinary, but she has said “it is a burden” [2]. On the other hand, Kanner’s clinical description of au‐ tistic disorder suggested that excellent rote memory might be involved in its aetiology [3]. In addition, some authors have thought that S could have had an Autism Spectrum Disorder (ASD) [4,5]. So the question arises: if S could have had an ASD, then how might his memory have given rise to such an ASD? For this reason, the present chapter begins by reviewing the evidence for the diagnosis of autistic disorder in S using criteria from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Re‐ vision (DSM-IV-TR) of the American Psychiatric Association [6] and from proposed crite‐ ria for its fifth edition [7], the chapter also compares his symptoms with those from a famous case (DT) with Asperger syndrome [8,9]. It is concluded that S most likely had autistic disorder. Next, I reviewed the literature to determine whether the assumption that a superior memory may be the cause of autism symptoms would be acceptable or not. However, the data seem to show that S’s job as a professional mnemonist was asso‐ ciated instead with a gradual decrease in the severity of some of his autism symptoms [1], notwithstanding, there are great mnemonists without ASD [10,11]. Finally, an alterna‐ tive explanation regarding the possible relationship between superior memories and au‐
Workload Management Strategies and Employees Efficiency in the Nigeria Banking Sector

This empirical study takes a cross sectional survey design and it aims to capture workload management strategies and employees efficiency of Nigerian banks in Port Harcourt, Rivers State. Workload management is a critical function of supervisors therefore, only senior supervisors and managers of the studied banks were covered. Two hundred (200) managers and supervisors were drawn from the 6 banks and their branches, however, a total of one hundred and thirty-three (133) respondents were sampled using the Yaro Yamane statistics for sample determination from a finite population. Therefore, the sample size for this study is one hundred and thirty three (133). A total of 133 questionnaires were distributed across ten (10) commercial banks in Rivers State, out of which 130 questionnaires were returned, representing 98% of the questionnaire. Three (3) copies were left unfilled sequel to tide schedule of work activities as against the duration of this research; representing 2% of the questionnaire, which amounted to 100% in accordance to the 133 copies of questionnaires distributed. The responses gathered from the questionnaire were collected and scored for analysis using frequency table, mean, standard deviation and simple percentage, while the research hypotheses was be tested using Pearson product Moment Correlation coefficient. Findings lead to the recommendation that all dimensions of workload management strategies have relationship on employees efficiency of the banking sector studied.
Lost in Translation: Factors Influencing Successful Implementation of Evidence-Based Guidelines into Clinical Decision Support

Evidence-based guidelines are being produced at a very rapid rate but implementation into effective clinical decision support (CDS) is rare. Currently, there exists a gap between guideline development and successful implementation. Guidance for the development of trustworthy guidelines is lacking (Schünemann et al., 2014), and poor uptake of guidelines continues to be a major problem across healthcare systems (Gupta et al., 2016). Integration of guidelines through CDS can facilitate evidence-based medicine, which promises to standardize care and improve compliance with evidence-based protocols, thus improving patient outcomes (Chaudhry et al., 2006). The unsuccessful implementation of evidence-based guidelines is in part due to over-complexity (Francke, Smit, Veer, & Mistiaen, 2008), poor usability (Kastner et al., 2014), and poor applicability (Lugtenberg, Zegers-van Schaick, Westert, & Burgers, 2009). There are many external and internal factors that impact how new guidelines are received by the medical field. These factors refer to implementability, which is a set of characteristics that predict ease of, and obstacles to, guideline implementation (Kastner et al., 2014). The most frequently described facilitators of guideline uptake were format, content, language, and usability (Kastner et al., 2014). The aims of the current project were to: 1) Identify characteristics that support or impede evidence-based guideline implementation as CDS in critical care settings. 2) Create taxonomy to evaluate these characteristics. 3) Use that taxonomy to extract, summarize, and review relevant evidence-based guidelines. From a search of the current literature on implementability of evidence-based guidelines, we searched for articles published in PubMed between 2007 and 2017. Combinations of the following Medical Subject Headings (MeSH) terms were used: “guideline” AND “implementability”. Criteria for inclusion were: i) discussion of characteristics of features in guidelines; ii) English language; iii) recommendations for guideline development were summarized and used in the spectrum of healthcare; and iv) discussion of CDS. Generated from these recommendations, our novel taxonomy included the following five elements: development, format, content, language, and usability. We used this taxonomy to assess the CDS-implementability of 15 different guidelines across varying clinical domains, representing a cross-section of medicine with regards to clinical condition, target population, and guideline developer. Using the taxonomy as an abstraction tool, we identified characteristics of each of the 15 guidelines that would support and hinder their successful implementation into CDS. Our results showed that the different characteristics of implementability can be quantitatively measured, which would prove useful during the guidelines development. The implementability of a guideline, if considered throughout the development cycle, could lead to successful uptake into CDS in critical care settings.
The cholinergic, serotoninergic and peptidergic components of the nervous system of Moniezia expansa (Cestoda, Cyclophyllidea)

SUMMARY The central (CNS) and peripheral (PNS) nervous systems of the cyclophyllidean tapeworm, Moniezia expansa, were examined for the presence of cholinergic, serotoninergic and peptidergic elements using enzyme cytochemical and immunocytochemical techniques in conjunction with light and confocal scanning laser microscopy. Cholinesterase activity and 5-hydroxytryptamine- and regulatory peptide-immunoreactivities (IRs) were localized to the nerve fibres and cell bodies of all of the major neuronal components in the CNS of the worm, including the cerebral ganglia and connecting commissure, the 10 longitudinal nerve cords and associated transverse ring commissures. Although each of the 3 systems appeared well developed and comprised a significant portion of the nervous system, the serotoninergic constituent was the most highly developed, consisting of a vast array of nerve fibres and cell bodies distributed throughout the strobila of the worm. A close association of cholinesterase reactivity and peptide-IRs was evident throughout the CNS, indicating the possible co-localization of acetylcholine and neuropeptides. Within the PNS, cholinergic activity and serotoninergic- and peptidergic-IRs occurred in the subtegumental network of nerve fibres and somatic musculature. Although all 3 neuro-chemical elements were present in the acetabula, they were found in different nerve fibres; only cholinergic and peptidergic cell bodies were found. The common genital opening, vagina and ootype regions of the reproductive system displayed a rich innervation of all 3 types of neuronal populations. Within the peptidergic system, immunostaining with antiseraraised to the C-terminus of the neuropeptide Y superfamily of peptides and the invertebrate peptides, neuropeptide F (M. expansa) and FMRFamide was the most prevalent. Limited positive-IR for substance P and neurokinin A were also recorded in the CNS of the worm.
Research and Development Expenditure, Cash Conversion Cycle and Corporate Performance An Empirical Study of Chinese Listed Companies

With the development of science and technology, the globalization has contributed to the vigorous development of China’s economy. Business managers begin to recognize the importance of research and development expenditure and working capital management on the enterprise core competitiveness. Combining the background of listed companies in our country, and selecting 45 companies listed in the Shanghai stock exchange form 2012 to 2014 as the research sample, the paper discusses the correlation of research and development expenditure, cash conversion cycle and corporate performance. We find that research and development expenditure has a significant positive correlation with the enterprise performance; cash conversion cycle has a not significant negative correlation with the enterprise performance; research and development expenditure has a significant negative correlation with cash conversion cycle; the research and development expenditure spending of confirmed as intangible assets has a significant negative correlation with cash conversion cycle; the research and development expenditure spending of recorded into the profits and losses has a not significant negative correlation with cash conversion cycle; development spending has a significant negative correlation with cash conversion cycle. Keywords—research and development expenditure; cash conversion cycle; corporate performance
A Cross-Layer Design for mobile AD HOC Networking in Fast Fading Channels

In this paper, we propose a novel cross-layer design for mobile-to-mobile ad hoc networks. Our scheme makes use of the statistical characteristics of the fast fading channel and cross-layer concept to combat Rayleigh fast fading and improve radio channel utilization. A linear minimum mean square error (LMMSE) estimator employs past channel autocorrelation data to estimate the future fading status at the physical layer. The predicted channel status information (CSI) (SNR and average fading duration) is fed into the routing layer. The cross-layer architecture allows the routing layer to improve its decisions by sharing the physical layer knowledge. The proposed routing protocol EAOMDV (Extended AOMDV), which is an integration of the Ad Hoc On-Demand Multipath Distance Vector (AOMDV) routing protocol with CSI and handoff, selects the shortest stable route to improve the link quality. Contributing to the cross-layer design, each node in the network can perceive the status of other components and adapt to make the ad hoc network more adaptive and robust.
Enabling precision medicine via standard communication of HTS provenance, analysis, and results

A personalized approach based on a patient’s or pathogen’s unique genomic sequence is the foundation of precision medicine. Genomic findings must be robust and reproducible, and experimental data capture should adhere to FAIR guiding principles. Moreover, effective precision medicine requires standardized reporting that extends beyond wet lab procedures to computational methods. The BioCompute framework (https://osf.io/zm97b/) enables standardized reporting of genomic sequence data provenance, including provenance domain, usability domain, execution domain, verification kit, and error domain. This framework facilitates communication and promotes interoperability. Bioinformatics computation instances that employ the BioCompute framework are easily relayed, repeated if needed and compared by scientists, regulators, test developers, and clinicians. Easing the burden of performing the aforementioned tasks greatly extends the range of practical application. Large clinical trials, precision medicine, and regulatory submissions require a set of agreed upon standards that ensures efficient communication and documentation of genomic analyses. The BioCompute paradigm and the resulting BioCompute Objects (BCO) offer that standard, and are freely accessible as a GitHub organization (https://github.com/biocompute-objects) following the “Open-Stand.org principles for collaborative open standards development”. By communication of high-throughput sequencing studies using a BCO, regulatory agencies (e.g., FDA), diagnostic test developers, researchers, and clinicians can expand collaboration to drive innovation in precision medicine, potentially decreasing the time and cost associated with next generation sequencing workflow exchange, reporting, and regulatory reviews.