Miracle-dz/UniFAR-FTUs huggingface dataset:
In silico Molecular Docking Studies of Quercetin Compound against Anti-inflammatory and Anticancer Proteins

Quercetin (a plant flavonoid) having a spot with polyphenol extensively disseminated in nature. Quercetin has aglycone structure and other flavonoid glycosides are rutin and quercetin. The examination displayed the quercetin compound was the best compound exhibiting higher confining imperativeness. In the present examination quercetin was isolated from the leaf concentrate of Artemisia nilagirica (Clarke) Pamp and the concentrate was certified through various instrumental examinations. An undertaking has been made for docking study practices with the extraordinary perceived characteristics MSX 2, HOX A10, HOX A5 and MAPK 14 for quieting proteins and SGK-1, BAX, ZFN 26 and ADM for anticancer. The docking results showed that there exists a coupling relationship between each protein and the goal of ligand-protein docking is to anticipate the overwhelming confining models of a ligand with a protein of known three dimensional structures. Docking considers yielded basic information concerning the presentation of the inhibitors in the coupling pocket of the objective proteins. The present work recognizes the potential remedy that concentrations against the receptor proteins as a characteristic solution to cure inflammation and cancer. The examination reveals that Quercetin can go utilized as medication to fix irritation and dangerous development. Fundamental point of this examination is to limit the dangerous impact of open medications to the common human cell. The examination displayed the Quercetin compound was the best compound appearing limiting imperativeness when differentiated Quercetin and moderating protein MAPK14 receptor leaving - 9.7 kcal/mol and anticancer proteins SGK-1 receptor is - 9.5 kcal/mol of confining essentialness. Taken together our results show that Quercetin may go about as alleviating and anticancer compound by affecting the NF-? B pathway. Further examinations in pre-clinical and clinical examinations are justified to illuminate the helpful capability of Quercetin for clinical use.
The expression level of a recombinant lipase predicted in silico by different codon optimization algorithms

Optimizing codons of gene of interest has offered a value-added way to increase heterologous expression of proteins. Different algorithms have been designed to achieve this purpose. These algorithms make use of parameters such as codon Adaptation index (CAI), codon context (CC), percentage guanine-cytosine (GC) content and RNA instability for predicting optimal codons responsible for increased protein expression. Lipase 3646 is an enzyme with great potential for industrial applications. This enzymes has been described to possess thermostable properties with relative stability in high alkaline pH and at different concentrations of organic solvents and inhibitors. This research therefore used JCat, Codon optimization online (COOL), presyndocon and ExpOptimizer algorithms to predict expression level of lipase 3646 enzyme in silico by optimizing its gene coding sequence. The results showed that there were variations in the CAI generated by the algorithms for the same 3646 DNA sequence which suggests that each algorithm is specific for its own generated CAI. COOL algorithm prediction based on other parameters showed good results for potential expression of the lipase. Thus, we recommend COOL algorithm for codon optimization of the lipase 3646 gene for industrial applications. World Scientific News 137 (2019) 31-41 -32
Intraoperative Assessment of Syndesmotic Injury and How to Assess if the Syndesmosis is Reduced

Injuries to the tibiofibular syndesmosis are common, both as isolated injuries and as a component of rotational ankle fractures. Recent evidence suggests a high incidence of tibiofibular syndesmosis malreduction with poor clinical outcomes associated with syndesmotic malreduction. Despite the notable clinical consequences of malreduction and heightened awareness surrounding the issue of syndesmotic malreduction, intraoperative methods to assess the adequacy of syndesmotic reduction remain imperfect. Although postoperative axial computed tomographic (CT) scans are often used to assess the adequacy of syndesmotic reduction postoperatively, the routine use of intraoperative CT is limited by the availability of technology as well as the limited ability to perform side-by-side comparison with the uninjured ankle intraoperatively. Although more readily available for intraoperative assessment, fluoroscopy has consistently demonstrated shortcomings with respect to assessment of syndesmotic reduction. Although the literature clearly suggests that there is no perfect method to consistently obtain anatomic reduction of the syndesmosis, several intraoperative methods to optimize syndesmotic malreduction, including the importance of anatomic fracture fixation, open visualization of syndesmotic reduction, posterior inferior tibiofibular ligament repair or anatomic posterior malleolar fracture fixation, and deep deltoid ligament repair, have been suggested. The following will include a review of these concepts as well as relevant recent literature to provide a basis for improving methods to assess the adequacy of syndesmotic reduction intraoperatively.
Treatment Effects of Upper Limb Action Observation Therapy and Mirror Therapy on Rehabilitation Outcomes after Subacute Stroke: A Pilot Study

Background Action observation therapy and mirror therapy, two promising rehabilitation strategies, are aimed at enhancing the motor learning and functional improvement of stroke patients through different patterns of visual feedback and observation. Objective This study investigated and compared the treatment effects of the action observation therapy, mirror therapy, and active control intervention on motor and functional outcomes of stroke patients. Methods Twenty-one patients with subacute stroke were recruited in this study. All patients were randomly assigned to the action observation therapy, mirror therapy, or active control intervention for 3 weeks. Outcome measures were conducted at baseline, immediately after treatment, and at 3-month follow-up. The primary outcome was the Fugl-Meyer Assessment, and secondary outcomes included the Box and Block Test, Functional Independence Measure, and Stroke Impact Scale. Descriptive analyses and the number of patients whose change score achieved minimal clinically important difference were reported. Results Both the action observation therapy and active control intervention showed similar improvements on the Fugl-Meyer Assessment, Box and Block Test, and Stroke Impact Scale. Moreover, the action observation therapy had a greater improvement on the Functional Independence Measure than the other 2 groups did. However, the mirror therapy group gained the least improvements on the outcomes. Conclusion The preliminary results found that the patients in the action observation therapy and active control intervention groups had comparable benefits, suggesting that the 2 treatments might be used as an alternative to each other. A further large-scale study with at least 20 patients in each group to validate the study findings is needed. This trial is registered with NCT02871700.
Creative Writing - An Under-Utilized Cancer Therapy

Writing builds confidence in the writer and restores their emotional well being. This is an art of allowing self analysis and boosting self esteem. Truly, creative writing is a much under-utilized tool, as of now. It is very simple, just encourage patients to write. Initially they will find difficulties but very soon the crisis will be over. What will emerge will be an innovative piece of art with the deepest emotion benefitting the readers.
Urging Green Retrofits of Building Façades in the Tropics: A Review and Research Agenda

Green building development creates many opportunities for meeting the United Nation’s Sustainable Development Goals (SDGs). However, most green buildings are new builds rather than retrofitted existing buildings. This may become an impediment for green development progress, as the issues of deforestation and land preservation remain unresolved. Green retrofitting of building façades is one of the most effective passive design strategies and permits perennial benefits for building energy performance, cost savings, and positive environmental impacts. There are a wide range of façade retrofit technologies readily available on the market at relatively low cost that require little installation time and yet can achieve similar energy performance levels as new green buildings. Notwithstanding these advantages, the uptake rates for these are moderately low. The challenges to widely implementing façade retrofitting of Malaysian office buildings are foreseen as holistic and include not just engineering and construction activities, but also social, economic, environmental, and governmental support. This paper aims to review the focus and direction of green development in the Malaysian construction industry and subsequently propose a research agenda for the rapid adoption of green façade retrofitting for local office buildings. The research agenda will commence with a survey on key factors that impede the uptake of green façade retrofitting, and then conducts energy simulations for contemporary green facade technologies (GFTs) using Building Information Modelling (BIM) software. It finally develops a decision-making tool for GFT selection based on simulated energy performance data and the key factors associated with building owners’ considerations and expectations of façade retrofitting. The final research output is expected to act as a catalyst to spur green development progress by identifying the real issues faced by the prevailing construction industry.
Effect of Maternal Education, Early Marriage and Prenatal Care on Child Undernutrition in Ethiopia

Studies done before identified that children in developing countries suffered from consistent undernutrition problem. This study identified the effect of maternal education, prenatal care and early marriage on child undernutrition problems in the four dominant regional states of Ethiopia (Tigray, Amhara, Oromia and SNNP). The study considered the four nationally representative demographic and health survey data collected by the World Bank in 2000, 2005, 2011 and 2016. The child undernutrition problems (stunting, underweight and wasted) computed based on the standardized index developed by the World Health Organization. On average 47.55%, 39.22% and 9.34% of the sample children in the four round surveys were stunted, underweight and wasted, respectively. Sample children from Amhara regional state had severe stunting and underweight problems as compared to the other regional states of the country. The logit model result revealed that experienced and educated mothers have significant effect of reducing the child undernutrition in Ethiopia. Children from mothers with age interval of 35-45 years and graduated from secondary and/or high school have strong probability of being free from stunted, underweight and wasted in the country. The model result also shows that children with an average or more birth weight have lower probability of suffering from childhood undernutrition. Additionally, the study found that children from rural areas have strong prevalence for undernutrition as compared to the urban ones. In connection to this, the household wealth quintals have significant effect on child undernutrition, wherein children from rich family have lower probability of prevalence to stunting and underweight. Finally, the study recommended that the concerned part should work on expanding mother’s education, prenatal care and awareness of rural households to reduce the national level child undernutrition problem significantly.
Indicators for lumens distinction on 3D CT aortic dissection images

Our works are related to the planning and assistance to manage aortic dissections during interventions. Aortic dissection is a life-threatening medical emergency associated with high rates of morbidity and mortality. It consists in one or several tears which begin in the intima allowing blood to travel through a diseased media layer. This process cleaves the normal bed of blood into two lumens (true lumen and false lumen) separated by an intimal membrane also called flap (Fig. 1(a)). See Fig. 1(b) and (c) for a 2D slice retrieved from one of our CT images. Recently, we have proposed a segmentation of the true and false lumens separately on 3D CT aortic dissection images [1] (see Tab. 1(b)). Our aim was to provide a 3D view of the lumens that we can difficultly obtain either by volume rendering or by another visualization tool which only directly gives the outer contour of the aorta; or by other segmentation methods because they mainly directly segment either only the outer contour of the aorta or other connected arteries and organs both. This segmentation was realized by modifying the speed term of the classical fast marching method. More particularly, the front propagation stops around intimal tears by dealing with intensity values (gradient). Our works consist in registering the segmented results from a CT aortic dissection image onto an angiographic sequence in order to assist clinicians during their interventions. An automatic lumen distinction allows us to propose a better control for endoprosthesis landing: the stent-graft trajectory must remain only inside the true lumen and not to pass through the false lumen. In this paper, we present two indicators to easily distinguish true and false lumens in our segmented results. More precisely, these indicators are also based on intensity.
Control of Fruit Cracking by Shaping Skin Traits – Apple as a Model

Abstract Skin cracking limits fruit quality and marketability. Suggested causes are environmental conditions, orchard management, and failure of the skin to resist surface tension due to fruit expansion. Fruit skin is made up of epidermis cells and cuticular matrix. Theoretical and experimental studies of skin mechanics, together with anatomical and molecular comparisons of cracking-susceptible vs. tolerant genotypes, suggest that increased cuticle thickness, high epidermal cell density and strong adhesion between neighboring cells are associated with cracking resistance. Calyx-end cracking disorder in apple is treated with a mixture of gibberellic acids 4 and 7 (GA4 + 7) and the cytokinin 6-benzyladenine (BA) early in fruit development. The treatment not only significantly reduces cracking incidence in the orchard, it also provides information on the cellular and molecular factors determining fruit-skin resistance to growth strain. BA + GA4 + 7 application results in an immediate increase in epidermal cell density that is maintained until fruit maturation. Moreover, the epidermal cells form clusters within the cuticular matrix, which may strengthen the cuticle by adding more cell-wall components and may enhance crack repair. Skin anatomical modifications are complemented by the expression of genes associated with epidermal cell patterning and cuticle formation. Gene-networking analysis supports the interaction between cell-wall synthesis, cuticle-formation, and GA-signaling gene clusters. Overall, data suggest that BA + GA4 + 7 treatment does not modify developmental cues, but promotes or enhances the innate developmental program. This review presents data on BA- and GA4 + 7-induced skin modifications that complement previously suggested models for cracking resistance in fruit. Knowledge gained on apple fruit skin traits may be applied to control cracking in other fruit as well.
Psychosocial impairments among adults with epilepsy in a neurology clinic in Nigeria

Objective: Psychosocial problems unattended to may compromise adequate control of seizures and elevate the risk of psychopathology. We assessed for psychosocial impairments and associated psychopathology in patients with epilepsy, with the hope that findings will help initiate formal psychosocial care for patients attending the neurology clinic. Methods: Consecutive patients with epilepsy seen at the neurology clinic that met the inclusion criteria and gave consent were interviewed in a 2 stage procedure. In the first stage patients were assessed with a semi-structured questionnaire containing psychosocial variables while probable psychiatric morbidity was assessed with General Health Questionnaire (GHQ-12). In the second stage psychiatric diagnoses were assessed with Schedule for Clinical Assessment in Neuropsychiatry (SCAN). Results: Many of the patients reported difficulties in at least one or more of the psychosocial domains assessed; areas of difficulty included: physical activity (52.4%), occupational activity (46.8%); finances (41.3%); stigma (33.3%); inadequate social support by relatives (31.7%), and perceived inadequate general adjustment (34.9%). Psychosocial factors significantly associated with increased rate of psychopathology included: being a woman, having low education; financial difficulties and limitations in physical activities while significant clinical factors included: having frequent fits and partial epilepsy. Multiple logistic regression analyses indicated that being a woman and having partial seizures were the most important predictors of psychopathology among the patients. Conclusion: This study has provided evidence of the need to introduce routine psychosocial care in our neurology clinic which hitherto did not carry out structured routine assessment of psychosocial problems in order to reduce risk of psychopathology.
Teacher Shortage in School-Based, Agricultural Education (SBAE): A Historical Review

Ongoing teacher shortages in SBAE have been a concern dating back to the Smith-Hughes Act of 1917 (Hillison, 1987). This historical inquiry identified the longitudinal trends revealed by data derived from the supply and demand studies of SBAE teachers over a 51-year period, and how the studies and their reporting procedures evolved. On average, between 50% and 60% of graduates prepared to teach SBAE nationwide did so during their first year after graduation. The studies’ research teams changed eight times, including 12 lead investigators from eight institutions and, in the case of two reports, the National FFA Organization assisted. Reporting cycles also changed over time. Perhaps the long-term graduates-to-entrants trend should be accepted as canon and stakeholders redouble efforts to recruit a larger pool of future teachers and improve the likelihood of graduates who enter the profession also choosing to remain.
A Near-Optimal Protocol for the Grouping Problem in RFID Systems

Radio frequency identification (RFID) has been widely used in many fields such as object tracking and inventory management. For RFID systems, grouping is a fundamental issue which can support efficient multicast transmissions, dynamic tag management, and accurate aggregate queries. Existing grouping protocols have drawbacks of unknown theoretical communication time, high computational cost on the server end and inability to deal with unexpected tags which are those tags whose IDs have not been collected by readers. In this paper, we would like to address the above limitations and consider a more general grouping problem that allows an arbitrary number of unexpected tags to present. Our objective is to design a protocol that guarantees the reader to efficiently and correctly notify each known tag of its group-ID, while the probability that an unexpected tag is mistakenly notified of any group-ID is smaller than a pre-determined value. In this paper, we first obtain a lower bound on the communication time for solving this generalized grouping problem. Then, we propose a near-optimal protocol, called OPT-G, and prove that its communication time approximately equals the lower bound. Finally, we report extensive simulation results that demonstrate OPT-G's near-optimal performance and its superiority over existing baseline schemes.
Scintillation Properties and Energy Transfer in (GdY)AlO₃:Ce³⁺ Perovskites With High Gd Content

The scintillation, optical, and photoluminescence properties of yttrium gadolinium aluminum perovskites activated by Ce<sup>3+</sup> ions, (Y<sub>1−<italic>x</italic></sub>Gd<sub><italic>x</italic></sub>)AlO<sub>3</sub>:Ce<sup>3+</sup>, were studied. A set of single-crystalline films with Gd content from <inline-formula> <tex-math notation="LaTeX">$x = 0$ </tex-math></inline-formula> to 1 was grown by the liquid phase epitaxy. At higher Gd content, the bidirectional nonradiative energy transfer (ET) between Ce<sup>3+</sup> and Gd<sup>3+</sup> ions was observed, and an adequate model that took into consideration the energy migration over the Gd subsystem was suggested. The results decidedly showed that in samples with low Gd content, <inline-formula> <tex-math notation="LaTeX">$x < 0.2$ </tex-math></inline-formula>, the ET from Gd<sup>3+</sup> to Ce<sup>3+</sup> ions prevailed, which increased the light output. However, slow components appeared simultaneously in the scintillation decays. At high Gd concentrations, the nonradiative back ET from Ce<sup>3+</sup> to Gd<sup>3+</sup> predominated, which resulted in a considerable acceleration of scintillation decays from 28 ns in YAlO<sub>3</sub>:Ce to less than 2 ns in GdAlO<sub>3</sub>:Ce, but simultaneously the Ce<sup>3+</sup> emission was significantly reduced.
Spironolactone in pulmonary arterial hypertension: results of a cross-over study

The renin–angiotensin–aldosterone system is implicated in the pathophysiology of pulmonary arterial hypertension. We undertook this study to determine the effects of spironolactone, a mineralocorticoid receptor blocker, on collagen metabolism in pulmonary arterial hypertension patients. After obtaining institutional review board approval and informed consent, 42 pulmonary arterial hypertension patients were prospectively enrolled and 35 patients completed the 16-week randomized double-blinded crossover clinical trial. Subjects received 50 mg spironolactone or placebo and at the end of week 8, treatment arm was switched. Circulating levels of collagen biomarkers, brain natriuretic peptide, and aldosterone levels were measured, and six-minute walk distance, liver function tests, and echocardiogram data were collected at weeks 0, 8, and 16. Mean age was 45 ± 15 years and 87% were females. At baseline, brain natriuretic peptide and aldosterone levels were 74 ± 95 pg/ml and 7 ± 8 pg/ml, respectively. There was no change in the levels of amino-terminal propeptide of procollagen type III (PIIINP), MMP-9, TIMP-1, and MMP-9/TIMP-1 ratio at weeks 8 and 16 compared to baseline values in placebo arm and treatment arm. The baseline six-min walk distance was 436 ± 115 meters at baseline and no change in walk distance was noted at weeks 8 and 16 (P = 0.372). None of the patients developed hyperkalemia or liver function test abnormalities at weeks 8 and 16 requiring discontinuation of study drug. Our study showed no change in collagen metabolite levels in pulmonary arterial hypertension patients treated with spironolactone. Spironolactone was safe and well tolerated by pulmonary arterial hypertension patients with no increased hyperkalemia or liver function test abnormalities.
The changing demand of digital skills in Finnish industries : Industrial engineering and management discipline

Author: Kajal Bhandari Title: The changing demand of digital skills in Finnish Industries: Industrial Engineering and Management discipline Faculty: School of Engineering Science Master’s Program: Global Management of Innovation and Technology Year: 2019 Place: Lappeenranta Master’s Thesis: LUT University 99 Pages, 17 Figures, 17 Tables and 3 appendices 1 Supervisor: 2 Supervisor: Professor Ville Ojanen Associate Professor Lea Hannola