Miracle-dz/UniFAR-FTUs huggingface dataset:
Hand motor cortical area reorganization in stroke: a study with fMRI, MEG and TCS maps

THE anatomical and functional correlates of the hand sensorimotor areas was investigated in a stroke patient with a malacic lesion in the left fronto-parieto-temporal cortex. The patient presented hemiplegia and motor aphasia 12 months earlier, followed by an excellent motor recovery. Transcranial magnetic stimulation mapping, functional magnetic resonance and magnetoencephalography were used as methods of functional imaging and all yielded consistent results. In particular, an asymmetrical enlargement and posterior shift of the sensorimotor areas localized in the affected hemisphere were found with all three techniques. Aspects related to brain ‘plasticity’ for functional recovery are discussed.
Eduardo Primo Yúfera, founder of Revista de Agroquímica y Tecnología de Alimentos and pioneer on Food Science and Technology research in Spain

Eduardo Primo Yúfera was the founder and director of the Instituto de Agroquímica y Tecnología de Alimentos (IATA, 1957-1974) until he was appointed president of the Consejo Superior de Investigaciones Científicas (CSIC). His aim to publicize food science led him to create the Revista de Agroquímica y Tecnología de Alimentos in 1961, the forerunner of this journal, Food Science and Technology International, which he directed until 1977. Of his scientific output, 50% has been published in this journal. He is considered to be the promoter and exponent of Food Science and Technology and Chemical Ecology in Spain as well as the instigator of the country's innovation model (R&D and innovation). In his work, he was able to combine basic research excellence and socially relevant applied research to move both science and society forward. He was an example and inspiration to many colleagues and followers. The aim of this study is to highlight the influence and importance of Primo Yúfera in the formation, development and consolidation of the journal Revista de Agroquímica y Tecnología de Alimentos, and to appraise his scientific contribution to this journal.
Susceptibility to Fraud in Systematic Reviews: Lessons from the Reuben Case

Background:Dr. Scott Reuben allegedly fabricated data. The authors of the current article examined the impact of Reuben reports on conclusions of systematic reviews. Methods:The authors searched in ISI Web of Knowledge systematic reviews citing Reuben reports. Systematic reviews were grouped into one of three categories: I, only cited but did not include Reuben reports; II, retrieved and considered, but eventually excluded Reuben reports; III, included Reuben reports. For quantitative systematic reviews (i.e., meta-analyses), a relevant difference was defined as a significant result becoming nonsignificant (or vice versa) by excluding Reuben reports. For qualitative systematic reviews, each author decided independently whether noninclusion of Reuben reports would have changed conclusions. Results:Twenty-five systematic reviews (5 category I, 6 category II, 14 category III) cited 27 Reuben reports (published 1994–2007). Most tested analgesics in surgical patients. One of 6 quantitative category III reviews would have reached different conclusions without Reuben reports. In all 6 (30 subgroup analyses involving Reuben reports), exclusion of Reuben reports never made any difference when the number of patients from Reuben reports was less than 30% of all patients included in the analysis. Of 8 qualitative category III reviews, all authors agreed that one would certainly have reached different conclusions without Reuben reports. For another 4, the authors’ judgment was not unanimous. Conclusions:Carefully performed systematic reviews proved robust against the impact of Reuben reports. Quantitative systematic reviews were vulnerable if the fraudulent data were more than 30% of the total. Qualitative systematic reviews seemed at greater risk than quantitative.
Early micturating cystourethrograms after urinary tract infection

Editor,—Craig et al showed that timing of micturating cystourethrography (MCU) does not affect the detection and grading of vesicoureteric reflux (VUR) if the test is performed more than one week after diagnosis and treatment of a urinary tract infection (UTI). 1 There is a view that early MCU may reveal a higher prevalence of VUR …
Virulence and antimicrobial resistance in enterococci isolated from urinary tract infections.

PURPOSE Urinary tract infection (UTI) is the most common nosocomial infection among hospitalized patients. Meanwhile, most frequent infections involving enterococci affect the urinary tract. The aims of this study were to investigate the susceptibility pattern of isolated enterococci from UTI and the prevalence of virulence genes. METHODS The study used enterococci isolated from urinary tract infections obtained from 3 university teaching hospitals in Northwest Iran. The antimicrobial susceptibility of the strains was determined using the disc diffusion method. Multiplex PCR was performed for the detection of genus- species specific targets, and potential virulence genes. RESULTS Of 188 enterococcal isolates, 138 (73.4%) and 50 (26.6%) were Enterococcus faecalis and E. faecium, respectively. Antibiotic susceptibility testing showed high resistance to amikacin (86.2%), rifampicin (86.2%) and erythromycin (73.9%), irrespective of species. In total, 68.1% were positive for gelE, and 57.4%, 53.2%, 56.4%, and 52.1% of isolates were positive for cpd, asa1, ace, and esp, respectively. CONCLUSION The study revealed that most of UTI isolates were multidrug resistance against the antibiotics tested and antibiotic resistance was more common among E. faecium isolates than E. faecalis. A significant correlation was found between UTI and the presence of gelE among E. faecalis strains (p < 0.001).
On the Use of Qualitative Comparative Analysis in Management

Researchers now use qualitative comparative analysis (QCA) beyond its original purposes in political and sociological sciences and apply this method of analysis in the field of management. This article offers a comprehensive and critical review of all the uses of QCA in management studies up until February 2015. This study shows how QCA extends beyond an empirical technique and how this method offers a genuine formalization of qualitative analysis, which opens new ways of knowledge production in management scholarship. This also study provides important implications for business management research.
10.2 Tbit/s (256x42.7 Gbit/s PDM/WDM) transmission over 100 km TeraLight/sup TM/ fiber with 1.28 bit/s/Hz spectral efficiency

We demonstrate the transmission of 256 polarization-division and wavelength-division multiplexed channels at 42.7 Gbit/s rate over 100 km of TeraLight/sup TM/ fiber. An overall capacity of 10 Tbit/s is achieved in C and L bands at a record 1.28 bit/s/Hz spectral efficiency.
Glacial seismology

Seismic source and wave propagation studies contribute to understanding structure, transport, fracture mechanics, mass balance, and other processes within glaciers and surrounding environments. Glaciogenic seismic waves readily couple with the bulk Earth, and can be recorded by seismographs deployed at local to global ranges. Although the fracturing, ablating, melting, and/or highly irregular environment of active glaciers can be highly unstable and hazardous, informative seismic measurements can commonly be made at stable proximal ice or rock sites. Seismology also contributes more broadly to emerging studies of elastic and gravity wave coupling between the atmosphere, oceans, solid Earth, and cryosphere, and recent scientific and technical advances have produced glaciological/seismological collaborations across a broad range of scales and processes. This importantly includes improved insight into the responses of cryospheric systems to changing climate and other environmental conditions. Here, we review relevant fundamental physics and glaciology, and provide a broad review of the current state of glacial seismology and its rapidly evolving future directions.
SIRT 1 regulates C 2 C 12 myoblast cell proliferation by activating Wnt signaling pathway

Sirtuin type 1 (SIRT1) is a potent NAD+ dependent deacetylase that deacetylates histone and nonhistone proteins to regulate gene expression and protein activity. Emerging evidences have indicated that SIRT1 plays a significant role in diverse cellular processes including cell growth, differentiation, development, and physiological function in muscle cells; however the signaling mechanisms involved remain to be established. In order to investigate its potential role in muscle biological processes, we administrated C2C12 cells which were isolated from skeletal muscle tissue of dystrophic mice with SIRT1 activator resveratrol (REV), inhibitor nicotinamide (NAM) and Wnt inhibitor FH535. By CCK-8, BrdU assay, real-time PCR and Western blot, we investigated whether the SIRT1 has a function in C2C12 cells by promoting β-catenin accumulation. Our results demonstrate that SIRT1 increases cell proliferation of C2C12 myoblast in a SIRT1-dependent manner. And SIRT1 significantly up-regulates the expression of cyclin D1, C-myc and Dvl2 in vitro as well as stimulates the accumulation of the Wnt/β-catenin. In conclusion, this study indicates that SIRT1 promotes the proliferation of C2C12 myoblast cells, at least partly via Wnt signaling pathway.
Yersinia Enterocolitica: A Panoramic View of a Charismatic Microorganism

AbstractYersinia enterocolitica, a small, Gram-negative coccobacillus which culturally and biochemically resembles members of the family Enterobacteriaceae, is widespread in nature, particularly in both domestic and wild mammals and birds. Human infection caused by this microorganism has been well documented in Europe, primarily in Scandinavian countries, and is now being increasingly appreciated in the United States, Canada, South Africa, and Japan. Infection with Y. enterocolitica usually presents as acute mesenteric lymphadenitis and terminal ileitis, although gastroenteritis, erythema nodosum, polyarthritis, septicemia, meningitis, cellulitis, conjunctivitis, and subacute localized abscesses in liver and spleen have also been recorded. Beginning with a review of historical milestones since its first description in the U.S. in 1939, this article will endeavor to place into perspective those factors contributing to the recognition and awareness in the U.S. of this long-discounted human pathogen. Pertine.
Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide: Clinical and Basic Studies

Arsenic trioxide (As2O3) has recently been identified as an effective drug in the treatment of newly diagnosed and relapsed acute promyelocytic leukemia (APL) without cross-resistance to all-trans retinoic acid and achieved complete remission rates of 80–90% according to most reports. With intravenous infusion at a dose of 0.08–0.16 mg/kg daily, a course of 28–42 days is required to induce remission. As2O3 in combination with chemotherapy as postremission therapy results in longer survival than arsenic alone. In vitro, As2O3 exerts dose-dependent dual effect; triggering apoptosis at relatively high concentration (0.5–2.0 μmol/1), which is associated with the disruption of mitochondrial transmembrane potentials, while inducing partial differentiation at low concentration (0.1–0.5 μmol/1), which might be related to retinoic acid signaling pathway. Importantly, at both concentrations, As2O3 can degrade PML (promyelocytic leukemia)-RARα (retinoic acid receptor), an oncoprotein that has a central role in leukemogenesis.
Nosocomial Infection Reduction in VLBW Infants With a Statewide Quality-Improvement Model

OBJECTIVE: To evaluate the effectiveness of the California Perinatal Quality Care Collaborative quality-improvement model using a toolkit supplemented by workshops and Web casts in decreasing nosocomial infections in very low birth weight infants. DESIGN: This was a retrospective cohort study of continuous California Perinatal Quality Care Collaborative members' data during the years 2002–2006. The primary dependent variable was nosocomial infection, defined as a late bacterial or coagulase-negative staphylococcal infection diagnosed after the age of 3 days by positive blood/cerebro-spinal fluid culture(s) and clinical criteria. The primary independent variable of interest was voluntary attendance at the toolkit's introductory event, a direct indicator that at least 1 member of an NICU team had been personally exposed to the toolkit's features rather than being only notified of its availability. The intervention's effects were assessed using a multivariable logistic regression model that risk adjusted for selected demographic and clinical factors. RESULTS: During the study period, 7733 eligible very low birth weight infants were born in 27 quality-improvement participant hospitals and 4512 very low birth weight infants were born in 27 non–quality-improvement participant hospitals. For the entire cohort, the rate of nosocomial infection decreased from 16.9% in 2002 to 14.5% in 2006. For infants admitted to NICUs participating in at least 1 quality-improvement event, there was an associated decreased risk of nosocomial infection (odds ratio: 0.81 [95% confidence interval: 0.68–0.96]) compared with those admitted to nonparticipating hospitals. CONCLUSIONS: The structured intervention approach to quality improvement in the NICU setting, using a toolkit along with attendance at a workshop and/or Web cast, is an effective means by which to improve care outcomes.
Developmental changes in adhesion molecule expressions in umbilical cord blood CD34 hematopoietic progenitor and stem cells.

OBJECTIVE The purpose of this study was to determine whether expressions of the cell adhesion molecules LFA-1 (CD11a), VLA-4 (CD49d), and L -selectin (CD62L ) on CD34(+) stem and progenitor cells in umbilical cord blood change during gestation. STUDY DESIGN In a prospective observational study 3-color fluorescence-activated cell sorting was used to assess the levels of expression of CD11a, CD49d, and CD62L on CD34(+) cells in fresh cord blood samples collected at delivery between 22 and 42 weeks' gestation. RESULTS The relative number of CD34(+) cells decreased as gestational age increased (r = -0.71; P<.001). Conversely, we found significant increases in cell adhesion molecule expression by CD34(+) cells during gestation (LFA-1, r = 0.47; P =.001; VLA-4, r = 0.33, P =.031; L -selectin, r = 0.61; P<.001). Comparisons between grouped samples from early preterm (22-32 weeks' gestation), late preterm (33-37 weeks' gestation), and term (38-42 weeks' gestation) infants confirmed this correlation and revealed that the major increases occurred between early and late preterm gestation. CONCLUSION These results suggest a role for cell adhesion molecule expression in the process of migration and homing of circulating stem cells to the fetal bone marrow toward the end of pregnancy. The findings may have implications for the use of preterm cord blood for hematopoietic stem cell transplantation and also for prenatal gene therapy.
A circuit concept for reducing soft-error in high-speed memory cells

This paper describes a circuit concept for reducing the soft error of high-speed flip-flop type memory cells. For bipolar static memory cells, the essence of the concept is that the potential at the common-emitter node of the cross-coupled transistors (flip-flop) should be allowed to swing freely. This can be implemented by decoupling the common-emitter node from the heavily-capacitively-loaded lower-word line, for example, by inserting a current source or a current mirror between the two. The predicted improvement of QCK1T, soft-error rate, and the experimental results are presented.
Development of decoupling capacitor embedded interposers using narrow gap chip parts mounting technology with wideband ultralow PDN impedance

We have developed a new chip capacitor embedded interposer using a narrow gap chip parts mounting technology. This interposer is expected to reduce power distribution network (PDN) impedance. To investigate the efficacy of the interposer, we have fabricated other various types of capacitor embedded interposer test element group (TEG), such as a generally chip capacitor embedded organic interposer, a thin film capacitor on a silicon interposer using the same design. We evaluated PDN impedance of decoupling capacitor embedded interposers for 3-D integrated LSI system by using a developed ultralow impedance evaluation system. As a result, the chip capacitor embedded interposer using the narrow gap chip parts mounting technology shows a low PDN impedance below 0.1 Ω could be evaluated at the frequency range of up to 10 GHz. This is realized that the interposer shows the comparable level of the PDN impedance as the thin film capacitor embedded silicon interposer. It can be realized that the PDN impedance of the interposer shows below 1/100 compared with a general interposer with embedded the chip capacitor parts of 0603 types.
An Ikaros-Containing Chromatin-Remodeling Complex in Adult-Type Erythroid Cells

ABSTRACT We have previously described a SWI/SNF-related protein complex (PYR complex) that is restricted to definitive (adult-type) hematopoietic cells and that specifically binds DNA sequences containing long stretches of pyrimidines. Deletion of an intergenic DNA-binding site for this complex from a human β-globin locus construct results in delayed human γ- to β-globin switching in transgenic mice, suggesting that the PYR complex acts to facilitate the switch. We now show that PYR complex DNA-binding activity also copurifies with subunits of a second type of chromatin-remodeling complex, nucleosome-remodeling deacetylase (NuRD), that has been shown to have both nucleosome-remodeling and histone deacetylase activities. Gel supershift assays using antibodies to the ATPase-helicase subunit of the NuRD complex, Mi-2 (CHD4), confirm that Mi-2 is a component of the PYR complex. In addition, we show that the hematopoietic cell-restricted zinc finger protein Ikaros copurifies with PYR complex DNA-binding activity and that antibodies to Ikaros also supershift the complex. We also show that NuRD and SWI/SNF components coimmunopurify with each other as well as with Ikaros. Competition gel shift experiments using partially purified PYR complex and recombinant Ikaros protein indicate that Ikaros functions as a DNA-binding subunit of the PYR complex. Our results suggest that Ikaros targets two types of chromatin-remodeling factors—activators (SWI/SNF) and repressors (NuRD)—in a single complex (PYR complex) to the β-globin locus in adult erythroid cells. At the time of the switch from fetal to adult globin production, the PYR complex is assembled and may function to repress γ-globin gene expression and facilitate γ- to β-globin switching.
A Six-Dimensional Magnetic Localization Algorithm for a Rectangular Magnet Objective Based on a Particle Swarm Optimizer

To build a wireless capsule endoscope with active external guidance for controllable and interactive diagnosis on the gastrointestinal tract, it is necessary to track the capsule's 3-D position and 3-D orientation. An approach to tracking is to enclose a small rectangular permanent magnet in the capsule. The magnetic field produced around the body by the rectangular magnet can be detected by magnetic sensors outside the patient's body. With these detected magnetic sensor data, the 3-D localization and 3-D orientation parameters can be computed by an appropriate algorithm based on the mathematical model of the rectangular magnet's magnetic field. We tried several nonlinear optimization algorithms, and simulation experiments show that the particle swarm optimization algorithm can work effectively with good accuracy when the magnet moves within a predetermined range.
Comments on the article ‘Defining hormesis’, by EJ Calabrese and LA Baldwin

In view of the diversity of biological responses and the extent to which many of them remain poorly elucidated, there is merit in the suggestion by Calabrese and Baldwin that the term ‘hormesis’ should be applicable to those adaptive responses that are characterized by biphasic dose–response relationships, without reference to any associated beneficial or harmful effects. Whether the dose–response relationships for radiation-induced mutations and chromosome aberrations are biphasic in nature is an important question that remains to be resolved.
Activation of Inhibitors by Sortase Triggers Irreversible Modification of the Active Site*

Sortases anchor surface proteins to the cell wall of Gram-positive pathogens through recognition of specific motif sequences. Loss of sortase leads to large reductions in virulence, which identifies sortase as a target for the development of antibacterials. By screening 135,625 small molecules for inhibition, we report here that aryl (β-amino)ethyl ketones inhibit sortase enzymes from staphylococci and bacilli. Inhibition of sortases occurs through an irreversible, covalent modification of their active site cysteine. Sortases specifically activate this class of molecules via β-elimination, generating a reactive olefin intermediate that covalently modifies the cysteine thiol. Analysis of the three-dimensional structure of Bacillus anthracis sortase B with and without inhibitor provides insights into the mechanism of inhibition and reveals binding pockets that can be exploited for drug discovery.
Approximation Algorithms for Dynamic Assortment Optimization Models

We consider a single-period joint assortment and inventory planning problem with stochastic demand and dynamic substitution across products, motivated by inventory management applications in highly differentiated markets, such as retailing, airlines, and consumer electronics. In its utmost generality, this problem is extremely hard to approximate with respect to various parameters. In fact, prior to the present paper, only a handful of modeling approaches were known to admit efficient algorithms with provably-good performance guarantees.Our main contribution is to provide the first polynomial-time algorithms with provable approximation guarantees for a broad class of dynamic assortment optimization models that capture real-life purchasing behaviors. From a technical perspective, we introduce a number of novel algorithmic ideas of independent interest, possibly applicable in broader settings, and unravel hidden relations to submodular maximization. In addition, our algorithms employ a mixture of greedy procedures, efficient enumerations methods, and low-dimensional dynamic programs, that are suitable for solving instances of practical nature and scale.