Miracle-dz/UniFAR-FTUs huggingface dataset:
[Relationship of fundus oculi changes to declines in mental and physical health conditions among elderly living in a rural community].

The prevalence of fundus oculi changes among elderly persons living in a rural community was investigated and the relationship of those changes to the development of cerebrovascular diseases (C.V.D.), total mortality, declines in mental and physical functions was examined. The subjects consisted of 241 residents aged 70 to 75 years as of 1986, in a rural area of Yamagata prefecture, Japan. The baseline survey was carried out in 1986, and the follow-up survey was done in 1991. The results obtained were as follows: 1) The fundus oculi examination revealed that among changes observed, there were high prevalences of senile tigroid fundus, drusen, broadened light reflex, and crossing phenomenon. 2) Multivariate analysis by Hayashi's Quantification III showed that the findings of broadened light reflex, crossing phenomenon, blood pressure, and ECG were discriminated from those of senile tigroid fundus, drusen, mental function as measured by the Benton Visual Retention Test, and physical functions. It was suggested that the former fundus oculi changes were related to circulatory disease, while the latter were related to aging. 3) A severe broadened reflex predicted a high occurrence of C.V. D. , and total mortality. In women, drusen had a significant direct relationship to a decline in score of the Benton Visual Retention Test. Retinal haemorrhage was related to higher total death rate in men, and women with crossing phenomenon tended to have strokes.
Ethanol-induced conditioned taste avoidance: reward or aversion?

BACKGROUND Rats avoid intake of a palatable taste cue when paired with all drugs of abuse tested. Evidence suggests that, at least for morphine and cocaine, rats avoid the taste cue because they are anticipating the rewarding properties of the drug. Thus, the suppressive effects of a rewarding sucrose solution and cocaine, but not those of the putatively aversive agent, lithium chloride (LiCl), are exaggerated in drug-sensitive Lewis rats. Likewise, the suppressive effects of sucrose and morphine, but not those of LiCl, are eliminated by bilateral lesions of the gustatory thalamus. Unlike morphine and cocaine, it is less clear whether rewarding or aversive drug properties are responsible for ethanol-induced suppression of intake of a taste cue. The present set of studies tests whether, like cocaine, ethanol-induced suppression of intake of a taste cue also is greater in the drug-sensitive Lewis rats and whether the suppressive effects of the drug are prevented by bilateral lesions of the taste thalamus. METHODS In Experiment 1, fluid-deprived Lewis and Fischer rats were given 5-minute access to 0.15% saccharin and then injected with saline or a range of doses of ethanol (0.5, 0.75, 1.0, or 1.5 g/kg). There was a total of 6 such pairings. In Experiments 2 and 3, Sprague-Dawley rats received bilateral electrophysiologically guided lesions of the gustatory thalamus. After recovery, suppression of intake of the saccharin cue was evaluated following repeated daily pairings with either a high (1.5 g/kg) or a low (0.75 g/kg) dose of ethanol. RESULTS Ethanol-induced suppression of intake of the saccharin conditioned stimulus (CS) did not differ between the drug-sensitive Lewis rats relative to the less-sensitive Fischer rats. Lesions of the taste thalamus, however, prevented the suppressive effect of the 0.75 g/kg dose of the drug, but had no impact on the suppressive effect of the 1.5 g/kg dose of ethanol. CONCLUSION The results suggest that the suppressive effects of ethanol on CS intake are mediated by both rewarding and aversive consequences, varying as a function of dose.
The impact of early nutrition on health: key findings from the Cebu Longitudinal Health and Nutrition Survey (CLHNS).

INTRODUCTION The Philippines' Cebu Longitudinal Health and Nutrition Survey (CLHNS) is one of the longest running birth cohort studies in Southeast Asia. This paper illustrates the pathways through which maternal and infant nutrition influence later health outcomes using selected CLHNS findings. METHODS The CLHNS initially examined the determinants and consequences of low birth weight and early nutrition on child growth and development. It has since expanded to study other health, nutrition, and demographic issues in the life course of the cohort participants such as the consequences of early nutrition on adult health. RESULTS CLHNS findings have documented important effects of poor maternal nutrition beyond impaired foetal growth (manifested through low birth weight). Mothers who had lower energy intakes and poorer nutritional status during pregnancy had offsprings who were at risk of having higher blood pressure measurements in adolescence. Infants born small at birth were not only more likely to be stunted through adolescence, but were also at greater risk of cardiovascular disease later in life. Among the males, those born thin at birth and have high BMI in adulthood had increased risk of elevated systolic blood pressure. Early infant feeding also had long-term effects on health. Breastfeeding not only protected against morbidity and stunting in childhood, but also lowered the risk of insulin resistance and high triglyceride levels in adulthood among the males. Delayed complementary feeding was associated a with lower risk of overweight in young adulthood. An intergenerational matrilineal effect was also observed among the participants, with maternal birth weight being positively associated with offspring birth weight. CONCLUSION The CLHNS findings support the WHO recommendations for exclusive breastfeeding until six months, timely introduction of complementary foods, and continued breastfeeding until two years. Since child nutrition begins in utero, programs should focus on improving maternal nutrition during pregnancy to minimise the risk of low birth weight.
Designing Green C-RAN with limited fronthaul via mixed-integer second order cone programming

This paper considers the downlink transmission of cloud-radio access networks with limited fronthaul capacity constraint. Unlike the existing approaches where power of fronthaul is a quadratic or linear function of respective variables, we consider a more practical model where the power consumed by fronthaul depends on the rate served by the corresponding remote radio head (RRH). Then, we formulate a joint design of RRH selection, RRH-user association, and transmit beamforming for the problem of energy efficiency maximization. The formulated problem is a mixed-integer nonconvex program, which is generally NP-hard. For this nonconvex program, we leverage successive convex approximation (SCA) method to develop efficient iterative algorithms to find a high performance. Particularly, we iteratively approximate the continuous nonconvex constraints by conic ones so that the problem obtained at each iteration is a mixed-integer second order cone programming (MI-SOCP) for which dedicated solvers are available. To further reduce the computational complexity, an algorithm based on continuous relaxation and post-processing is proposed. Results show that our proposed algorithms converge faster and outperform known solutions.
Surgical revascularization in the treatment of ventricular tachycardia and fibrillation exposed by exercise-induced ischaemia.

The role of myocardial revascularization in the treatment of malignant ventricular arrhythmias is not well defined. Our hypothesis was that in patients with ventricular tachycardia or fibrillation exposed by exercise-induced ischaemia, the acute transient ischaemia plays a principal causal role, and that in these patients surgical myocardial revascularization alone might be an effective treatment. Among 1100 consecutive patients undergoing isolated coronary artery bypass surgery (CABG) 30 patients (2.7%) characterized by ventricular tachycardia or fibrillation at the symptom-limited exercise tests prior to revascularization were studied prospectively. All patients had exercise-induced angina pectoris or ischaemic ST-segment depression preceding at least one of the arrhythmic events. In addition, eight of these 30 patients had experienced syncope during out-of-hospital exertional activities. After surgical revascularization, the 28 patients surviving to hospital discharge were followed for 1.6 to 86 months (mean 29 +/- 29 months) as outpatients and underwent between one to eight exercise tests (mean 2.6 +/- 1.9). One of these patients died suddenly of unknown causes at 14 months, another from cancer at 53 months. Twenty-six patients experienced a total of 34 episodes of ventricular tachycardia before revascularization. Two of these patients, both having residual ischaemia, had arrhythmia recurrences during follow-up; odds ratio (OR) 84.5, 95% confidence interval (CI) 18.7-381.9; P = < 0.010. Exercise-induced ventricular fibrillation occurred in eight patients pre-operatively. (ABSTRACT TRUNCATED AT 250 WORDS)
Neurodevelopmental Outcome Among Multiples and Singletons: A Regional Neonatal Intensive Care Unit's Experience in Turkey

Objective: The aim of this study was to compare the neurodevelopmental outcome at 12–18 months’ corrected age between multiples and singleton preterm infants. Methods: We designed a prospective study of preterm infants (≤32 weeks gestation) born and hospitalized in the neonatal intensive care unit between November 2008 and November 2009, whose assessments were performed at 12–18 months’ corrected age. Neurodevelopmental impairment was defined as the presence of any one of the following: moderate or severe cerebral palsy, severe bilateral hearing loss or bilateral blindness, mental developmental index score, or psychomotor developmental index score less than 70. Results were compared for both multiples and singleton infants. Results: One hundred and fifty-nine multiples and 211 singleton infants were assessed at 12–18 months’ corrected age. The neurodevelopmental outcome including all parameters at 12–18 months’ corrected age in multiples was not significantly different from singleton preterm infants. Conclusions: Multiple gestation in preterm infants is not associated with an increased risk of neurodevelopmental impairment at 12–18 months’ corrected age compared with singleton preterm infants. For further information, long term and high participation in neurodevelopmental follow-up and evaluation at pre-school age will be needed.
Chapter 1 Ubiquitylation and SUMOylation : An Orchestrated Regulation During DNA Damage Repair

DNA double-strand breaks (DSBs) are cytotoxic DNA lesions that must be repaired as soon as possible because it can cause chromosomal aberrations and cell death. Homologous recombination (HR) and nonhomologous end joining (NHEJ) are the pathways that mainly repair these ruptures. HR process is finely regulated by synchronized posttranslational modifications including phosphorylation, ubiquitylation, and SUMOylation. The ubiquitin (Ub) modifications at damaged chromatin serve as recruitment platforms for DSB repair complexes by facilitating binding sites or regulating the interaction between proteins. Thus, SUMOylation has been associated with protein interaction, enzymatic activity, and chromatin mobility. Several DNA damage factors have been found to be ubiquitylated and SUMOylated including histones (H2AX) and proteins such as Mre11, Rad51, NBS1, and BRCA1. Regarding ubiquitylation-mediated regulation of DNA repair, RNF168 and RNF8 E3 ligases have turned out to be a key step in DNA damage repair regulation. Interestingly, there is evidence that the Ub signaling mechanism is ancestral, and this emphasizes its importance.
Two-sided Absorptive Capacity: Customer Integration in Data-driven Environments

Companies are more and more turning to proactive customer integration and look for efficient ways of customer knowledge management. In case of online interaction, companies generate Big Data which holds the potential for the companies in terms of customer knowledge input. The potential of such data can be unfolded using advanced (predictive) analytics technologies. In order to ensure efficient customer integration in such settings, companies should be able to develop absorptive capacity. We assume that the nature of absorptive capacity in data-driven environments could be challenged, considering the intersection of business and technology perspectives. This study sets a foundation of understanding the peculiarities of absorptive capacity in data-driven environments by applying a qualitative case study approach. The study considers perspectives of both, service companies and analytics providers to avoid one-sided biases. The main result is an integration of empirical findings, their analysis against existing theoretical background and crystallization of a concept of 'two-sided absorptive capacity' which aims to explicate the role of analytics skills while building absorptive capacity in data-driven environments.
Moral choices : The influence of the “ Do not play God ” principle

A wide literature demonstrates that people prefer harm caused by omissions over equal or lesser harm caused by actions. This omission bias has been explained referring to several principles, such as causality or responsibility. A convincing research view has been suggested by Sunstein (2005): harmful acts are generally worse than harmful omissions when moral intuitions reflect the “Do not play God” principle: inactions interfere less with the “natural order. ” In two preliminary studies, we examine the influence of the “Do not play God” principle on individuals moral preferences, using the switch version of the trolley problem. Study 1 demonstrates that our participants’ justifications for their inaction choice explicitly refer to the intention of not interfering with the “natural order”. Study 2 demonstrates that the presence of stimuli influencing a reduction of protagonist’s decisional autonomy (e.g. an authority) activates the “Do not play God” principle, leading them to prefer inaction.
Mehmet Ozcan Novelist Calls Out Poemist : A Psycholinguistic and Contrastive Analysis of the Errors in T

This study is designed to investigate errors emerged in written texts produced by 30 Turkish EFL learners with an explanatory, and thus, qualitative perspective. Erroneous language elements were identified by the researcher first and then their grammaticality and intelligibility were checked by five native speakers of English. The analysis of the data showed that it is difficult to claim that an error stems from only one single factor since different features of an error are triggered by different factors. Our findings revealed two different types of errors: those which stem from the interference of L1 with L2 and those which are developmental ones. The former type contains more global errors whereas the errors in latter type are more intelligible. Keywords—Contrastive analysis, Error analysis, Language acquisition, Language transfer, Turkish
Specific physiological and biomechanical performance in elite, sub-elite and in non-elite male team handball players.

BACKGROUND Team handball is a dynamic sport game that is played professionally in numerous countries. However, knowledge about training and competition is based mostly on practical experience due to limited scientific studies. Consequently, the aims of our study were to compare specific physiological and biomechanical performance in elite, sub-elite and in non-elite male team handball players. METHODS Thirty-six elite, sub-elite and non-elite male team handball players performed a game based performance test, upper-body and lower-body strength tests, 30-m sprint test, counter movement jump test and an incremental treadmill running test. RESULTS Significant differences (P<0.05) were found for the peak oxygen uptake, heart rate, offense and defense time, jump height and ball velocity during the jump throw in the game based performance test, maximal oxygen uptake in the incremental treadmill running test as well as in maximal leg strength and leg explosive strength in the isometric strength test. CONCLUSIONS Elite male players have an enhanced specific agility, a better throwing performance, a higher team handball specific oxygen uptake and higher leg strength compared to sub-elite and non-elite players. Based on these results we recommend that training in team handball should focus on game based training methods to improve performance in specific agility, endurance and technique.
Identification and Characterization of a Diamine Exporter in Colon Epithelial Cells*

SLC3A2, a member of the solute carrier family, was identified by proteomics methods as a component of a transporter capable of exporting the diamine putrescine in the Chinese hamster ovary (CHO) cells selected for resistance to growth inhibition by high exogenous concentrations of putrescine. Putrescine transport was increased in inverted plasma membrane vesicles prepared from cells resistant to growth inhibition by putrescine compared with transport in inverted vesicles prepared from non-selected cells. Knockdown of SLC3A2 in human cells, using short hairpin RNA, caused an increase in putrescine uptake and a decrease in arginine uptake activity. SLC3A2 knockdown cells accumulated higher polyamine levels and grew faster than control cells. The growth of SLC3A2 knockdown cells was inhibited by high concentrations of putrescine. Knockdown of SLC3A2 reduced export of polyamines from cells. Expression of SLC3A2 was suppressed in human HCT116 colon cancer cells, which have an activated K-RAS, compared with their isogenic clone, Hkh2 cells, which lack an activated K-RAS allele. Spermidine/spermine N1-acetyltransferase (SAT1) was co-immunoprecipitated by an anti-SLC3A2 antibody as was SLC3A2 with an anti-SAT1 antibody. SLC3A2 and SAT1 colocalized on the plasma membrane. These data provide the first molecular characterization of a polyamine exporter in animal cells and indicate that the diamine putrescine is exported by an arginine transporter containing SLC3A2, whose expression is negatively regulated by K-RAS. The interaction between SLC3A2 and SAT1 suggests that these proteins may facilitate excretion of acetylated polyamines.
Finite Element Analysis on Nanomechanical Sensing of Cellular

Nanomechanical sensors have been emerging as a new type of sensor that can be applied to various fields. Nanomechanical sensors basically detect the two basic physical parameters: volume and/or mass. As all substances have volume and mass, almost any kind of substance should be detectable with the use of nanomechanical sensors. Many studies using nanomechanical sensors have been reported so far, ranging from gases to biological molecules.1,2 Not only molecules but also microorganisms such as viruses and bacteria can be detected by nanomechanical sensors.3,4 Since the first reports on nanomechanical sensing in 1994,5,6 cantilever-type sensors have been widely used as a typical nanomechanical sensor. In 2011, a membrane-type surface stress sensor (MSS) appeared as a practical sensing platform.7 While mechanobiology has been attracting much attention as a new field of cell biology,8 application of nanomechanical sensors to mechanobiology is one of the most interesting and challenging issues. In mechanobiology, it is important to evaluate the mechanical forces caused by cells in order to investigate how cells sense physical forces and respond to them. To measure the forces exerted through cellular functions such as adhesion, migration, and proliferation, micropatterned substrates including micropillar substrates are frequently used.9,10 However, it is known that the substrate topography causes a certain effect on the cellular functions.11,12 Nanomechanical sensors, on the other hand, can reduce such problems and might provide a new sensing platform with a plane surface. In this study, we investigate the nanomechanical sensing of cellular forces by means of finite element analysis (FEA) and evaluate the feasibility of nanomechanical sensors for mechanobiology. We performed FEA simulations on two kinds of nanomechanical sensors, a cantilever-type sensor and an MSS. The effects of cell position, cell size, the number of cells, and phase (spreading and contraction) are comprehensively investigated. We also investigate the optimization scheme for coating the sensors to amplify the sensing signals.
EPTN consensus-based atlas for CT-and MR-based contouring in neuro-oncology Taskforce

Purpose: To create a digital, online atlas for organs at risk (OAR) delineation in neuro-oncology based on high-quality computed tomography (CT) and magnetic resonance (MR) imaging. Methods: CT and 3 Tesla (3T) MR images (slice thickness 1 mm with intravenous contrast agent) were obtained from the same patient and subsequently fused. In addition, a 7T MR without intravenous contrast agent was obtained from a healthy volunteer. Based on discussion between experienced radiation oncologists, the clinically relevant organs at risk (OARs) to be included in the atlas for neuro-oncology were determined, excluding typical head and neck OARs previously published. The draft atlas was delineated by a senior radiation oncologist, 2 residents in radiation oncology, and a senior neuro-radiologist incorporating relevant available literature. The proposed atlas was then critically reviewed and discussed by European radiation oncologists until consensus was reached. Results: The online atlas includes one CT-scan at two different window settings and one MR scan (3T) showing the OARs in axial, coronal and sagittal view. This manuscript presents the three-dimensional descriptions of the fifteen consensus OARs for neuro-oncology. Among these is a new OAR relevant for neuro-cognition, the posterior cerebellum (illustrated on 7T MR images). Conclusion: In order to decrease interand intra-observer variability in delineating OARs relevant for neuro-oncology and thus derive consistent dosimetric data, we propose this atlas to be used in photon and particle therapy. The atlas is available online at www.cancerdata. org and will be updated whenever
Identifying Route Preferences over Origin-Destination Using Cellular Network Data

Current research on studying people's routing behavior focus on how to provide the minimum cost routes while ignore users' preference. Therefore, to analyze user's routing preference, identifying routes they actually choose is a crucial task. Cellular network data contains sufficient spatio-temporal information, which is widely used for trajectory analysis nowadays. However, it is a big challenge to extract precise trajectory from the cellular network data due to its low positioning accuracy. Compared to Density-Based Spatial Clustering of Applications with Noise algorithm, we present a Spatio-Temporal Density Clustering algorithm considering the timing sequence of the points to promote the precision of the trajectories, which aims to filter users' most probable routes with the map matching algorithm. Our approach could find out those most probable routes and the probability of each route. Finally, we experimented with real data. The results show that our approach is efficient for both extracting the probable trajectories and identifying multi-routes that users would prefer to route. Keywords—cellular network data; spatio-temporal data; trajectory data mining; origin-destination