Miracle-dz/UniFAR-FTUs huggingface dataset:
ICU incident reporting systems.

Intensive care is one of the largest and most expensive components of American health care. Studies suggest that errors and resulting adverse events are common in intensive care units (ICUs). The incidence may be as high as 2 errors per patient per day; 1 in 5 ICU patients may sustain a serious adverse event, and virtually all are exposed to serious risk for harm. Theories of error developed in aviation and other high-risk industries suggest that errors are likely to occur in all complex systems. Reporting of incidents, including both adverse events and near misses, is an essential component for improving safety. Voluntary, confidential reporting is likely to be more important than mandatory reporting. There have been a few efforts to apply such systems in medicine. In intensive care, the Australian Incident Monitoring System (AIMS)-ICU has been the most prominent. We have designed a Web-based ICU Safety Reporting System (ICUSRS). The goal is to identify high-risk situations and working conditions, to help change systems, and reduce the risk for error. The analysis and feedback of reports will inform the design of interventions to improve patient safety. The effort is aided substantially by collaboration with the 30 participating ICUs and important stakeholders including the Society of Critical Care Medicine, the American Society for Health-care Risk Management, the Food and Drug Administration Center for Devices and Radiological Health, the Foundation for Accountability, and the Leapfrog Group. A demonstration and evaluation of the system is underway, funded by the Agency for Healthcare Re-search and Quality.
Transmit Diversity Schemes for MIMO-OFDM Based Wireless Lan Systems

In this paper, we study the performance of two transmit diversity schemes, the cyclic delay diversity (CDD) and the groupwise space time block code (G-STBC), for high throughput wireless local area network (LAN) system using orthogonal frequency division multiplexing (OFDM) and multiple input multiple output (MIMO) technologies. We compare the performance of CDD and the G-STBC transmission with the VBLAST transmission using both convolutional code (CC) and low density parity check (LDPC) code. We show that G-STBC provides the best performance in all the three transmission schemes. The performance of CDD depends both on the frequency diversity of the channel and the power of coding. CDD has better performance advantage for systems with smaller multi-path and with powerful coding schemes. CDD also has the advantage of being receiver transparent
Targeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines

There is a growing understanding of why certain patients do or do not respond to checkpoint inhibition therapy. This opens new opportunities to reconsider and redevelop vaccine strategies to prime an anticancer immune response. Combination of such vaccines with checkpoint inhibitors will both provide the fuel and release the brake for an efficient anticancer response. Here, we discuss vaccine strategies that use C‐type lectin receptor (CLR) targeting of APCs, such as dendritic cells and macrophages. APCs are a necessity for the priming of antigen‐specific cytotoxic and helper T cells. Because CLRs are natural carbohydrate‐recognition receptors highly expressed by multiple subsets of APCs and involved in uptake and processing of Ags for presentation, these receptors seem particularly interesting for targeting purposes.
Giant Cells and Their Relation to Caseation in Tuberculosis.

The presence of giant cells, especially of the Langhans type, together with mononuclear tubercles is considered sufficient evidence in tissues to warrant the diagnosis of tuberculosis, even if tubercle bacilli are not demonstrated. Such cells are quite generally considered to be different from the ordinary foreign body giant cells and hence peculiar to tuberculosis. The frequent appearance of this cell in the midst of a tubercle, often occupying almost the whole of the structure, has led to the designation of such a lesion as a giant cell tubercle. To understand the significance of this cell mass in the tuberculous reaction, it would appear that two facts should be established. The first fact is the period in the tuberculous reaction in which the cell is produced, and the second is the mode of its formation and constitution. The material which formed the basis of this study is a large number of serially sectioned tissues from guinea-pigs experimentally infected with human and bovine bacilli, fowl naturally infected with the avian bacrnus and human tissues from necropsies and surgical operations. Serial sections were found of great value for two reasons. It was possible to examine the entire lesion and to reconstruct the giant cells, thus giving a more comprehensive idea of the size, shape and general characteristics of these cell masses.
Correlation between encoded protein overexpression and copy number of the HER2 gene with survival in non‐small cell lung cancer

The HER2 oncogene, which encodes the tyrosine kinase receptor, is commonly overexpressed in several types of cancer. Treatment using a humanized monoclonal antibody bound to HER2 product is becoming standard therapy for advanced breast cancer. Overexpression occurs in approximately 30% of non‐small cell lung cancers (NSCLCs) and has been associated with poor prognosis. However, the frequency of a genetic aberration in the HER2 gene in lung cancer and the association between gene amplification and prognosis are poorly defined. To clarify these relationships, we simultaneously analyzed protein overexpression by immunohistochemistry (IHC) and determined the gene copy number by FISH in 50 surgical specimens of NSCLC. A low‐grade increase in the copy number (3 to 8 copies) of the HER2 gene was detected in 44% of tumors. Most represented polysomy of chromosome 17. Protein overexpression was observed in 26%. Overexpression was detected in adenocarcinoma more frequently than in squamous cell carcinoma. No significant correlation was observed between copy number increase and overexpression. Neither gene copy number increase nor overexpression correlated with survival. We conclude that the significance of HER2 status in NSCLC is different from that in breast cancer because high‐grade amplification occurs rarely. © 2002 Wiley‐Liss, Inc.
Time series regression-based pairs trading in the Korean equities market

Abstract Pairs trading is an instance of statistical arbitrage that relies on heavy quantitative data analysis to profit by capitalising low-risk trading opportunities provided by anomalies of related assets. A key element in pairs trading is the rule by which open and close trading triggers are defined. This paper investigates the use of time series regression to define the rule which has previously been identified with fixed threshold-based approaches. Empirical results indicate that our approach may yield significantly increased excess returns compared to ones obtained by previous approaches on large capitalisation stocks in the Korean equities market.
Enfoques cuantitativo y cualitativo en el estudio de la alternancia pronombre personal/afijo en español

Este trabajo es un estudio de como influye la continuidad referencial con respecto a la clausula anterior en la alternancia pronombre personal / afijo de persona. Este factor ya se ha mostrado relevante en tal alternancia en trabajos anteriores. La aportacion de este estudio reside en, por una parte, tratar de extender la constatacion de esa influencia a las tres personas gramaticales y a las tres funciones donde es posible la alternancia entre pronombres personales y afijos -esto es, sujeto complemento directo y complemento indirecto- y, por otra parte, en mostrar hasta que punto el estudio cualitativo de ejemplos concretos complementa la perspectiva que de un fenomeno determinado nos da un enfoque cuantitativo. A tal efecto, se analizara una muestra procedente de dos corpus diferentes, uno constituido por conversaciones coloquiales y el otro por entrevistas semidirigidas.
Press Play2 - Gamification in Wissenschaft und Praxis

Der Begriff Gamification ist ein viel zitierter und stark diskutierter Begriff, unter dem im Allgemeinen der Einsatz von Spielelementen in spielfremden Kontexten (Deterding et al., 2011, S. 10) verstanden wird. Gamification bildet damit einen Gegensatz zu eher geschlossenen Anwendungsformen des Spiels, wie dem „Game-Based Learning“ (Prensky, 2007) oder den „Serious Games“ (Michael & Chen, 2005). Durch die Integration von Spielmechaniken werden sich eine höhere Flexibilität und höhere Akzeptanzraten, besonders in Produktivkontexten, erhofft. Zielsetzungen sind im Allgemeinen ein verbessertes Nutzererlebnis sowie die Steigerung von Motivation und Engagement gegenüber Produkten oder Prozessen (z. B. Herger, 2014). Der Zusammenhang aus diesen Nutzenversprechen, die weite Verbreitung smarter Technologien und die postulierte zunehmende Akzeptanz gegenüber Spielen durch nachwachsende Generationen (Prensky, 2007) begründen ein stark wachsendes Interesse an der Thematik in Wissenschaft und Unternehmen.
Efficient Image Resolution Enhancement Using Edge-Directed Unsharp Masking Sharpening for Real-Time ASIC Applications

This paper proposes the edge-directed unsharp masking sharpening (EDUMS) method and demonstrates the method’s ability to provide single-image resolution enhancement. The EDUMS method implements an efficient single-image, super-resolution process by synergizing edge-directed information and unsharp masking sharpening. This study designs a simple and robust edge information detection process for unsharp masking sharpening that is used to produce a clear edge structure and vivid details of high-resolution images with minimal ringing and jaggy artifacts. This method is a non-iterative process that is computationally efficient for use in a real-time integrated circuit design implementation.
How slippage-derived sequences are incorporated into rRNA variable-region secondary structure: implications for phylogeny reconstruction.

We analyzed the type and frequency of mutational changes in hypervariable rRNA regions, using the highly length-variable region V4 of the small subunit rRNA locus of tiger beetles (Cicindelidae) as an example. Phylogenetic analysis of indels in closely related species showed that (1) most indels are single nucleotides (usually A or T and sometimes G) or di-nucleotides of A and T. These occur at numerous foci, and they exhibit a strong bias for duplication of 5' single and di-nucleotide motifs but not 3' motifs. (2) Insertions/deletions in stem-forming regions affected paired and unpaired bases with about equal frequency but they did not disrupt the secondary structure. (3) Recurring mutations involving short repeats of the same bases caused parallel evolution of similar sequence motifs in the rRNA of different lineages. The observed types of change are consistent with the propostion that slippage is the main mutational mechanism. Slippage-derived sequences tend to be self-complementary, and therefore the stem-loop structure could be self-organizing as a consequence of the underlying mutational mechanism. Thus, the secondary structure in the cicindelid V4 region may be conserved due to the dynamics of the mutational mechanism rather than to functional constraints. These processes may also have a tendency to produce similar primary sequences irrespective of phylogenetic associations. The findings have implications for sequence alignment in phylogenetic analysis and should caution against the use of secondary structure to improve the determination of positional homology in hypervariable regions.
Energy efficiency of variable speed drive systems

A series of IEEE 112A performance tests were conducted in 1999 and 2000 by MSRF (Motor Systems Resource Facility), Oregon State University, Corvallis, Oregon. The results of those tests were reported in a paper presented in June 2001 at the IEEE/IAS PPIC Technical Conference in Portland Oregon. This paper suggests a similar series of performance tests for VSD (Variable Speed Drives) Systems. Most applications for VSD Systems involve variable torque loads, such as fans and centrifugal pumps, where the load varies as the cube of the speed. Performance tests of VSD systems are planned to measure efficiency of the VSD unit and the efficiency of the involved motor. While efficiency is a magic word, the real benefit of VSD systems is the reduction of energy used to provide the quantity of end product (fluid or air) of the pump or fan.
High-Temperature Superconducting Bandpass Filter Using Asymmetric Stepped-Impedance Resonators With Wide-Stopband Performance

This paper presents a wide-stopband high-temperature superconducting (HTS) bandpass filter (BPF). The filter is implemented by the asymmetric stepped-impedance resonators (SIRs) with only one step discontinuity, which leads to low loss and compact size. With varied characteristic impedance ratios and length ratios, the diversity of asymmetric SIR has been studied, and the spurious resonant-mode responses are discussed. Adopting different asymmetric SIR units operated at the same fundamental frequency f0 (2.4 GHz), its wide upper stopband can be realized by dispersing the higher order spurious resonant modes of these resonators. Furthermore, a modified input/output (I/O) feedline structure has been utilized to enhance the stopband performance. Finally, a fourth-order HTS BPF for wireless application is designed and fabricated on a MgO wafer with double-sided YBCO films. The filter measurement shows excellent performance with 0.05-dB minimum insertion loss and better than -20-dB rejection level in the stopband up to 10.46 GHz (about 4.4f0). In addition, the size of the HTS filter is 12.45 mm × 23 mm (i.e., 0.256 λg by 0.472 λg, where λg is the guided wavelength at the center frequency).
Clonal Optimization of Negative Selection Algorithm with Applications in Motor Fault Detection

In this paper, we employ the clonal optimization method to optimize the detectors in the negative selection algorithm (NSA). Taking advantage of the clonal optimization strategy, the NSA detectors can be optimized for anomaly detection. A new motor fault detection scheme using our NSA is also discussed. We demonstrate the efficiency of the proposed approach with an example of bearings fault detection.
Embedded System for Robotic Arm Movement Control using Web Server and ZigBee Communication

A robot is a virtual or mechanical artificial agent. In practice it is usually an electro-mechanical machine, which is guided by computer or electronic programming and is thus able to do tasks. Robots are outfitted with wide reaches and slim arms, steady repeatability and precise tooling-all, of which allows them to be extremely accurate. This high precision capability makes them a good match for pick and place application. Controlling robotic arm wirelessly is very helpful for a wide range of applications ranging from industrial to medical fields. The aim of this project is to develop a robotic arm which should be controlled by an authorized person at any time and from any place using the web technology. The robot is controlled by two methods, one through local system which has zigbee and the other through the web server which allows the client to access the robot from anywhere in the world. So the main advantage of our project is that there is no any limited distance is needed for running the robot.
Cost-effectiveness of HCV case-finding for people who inject drugs via dried blood spot testing in specialist addiction services and prisons

Objectives People who inject drugs (PWID) are at high risk for acquiring hepatitis C virus (HCV), but many are unaware of their infection. HCV dried blood spot (DBS) testing increases case-finding in addiction services and prisons. We determine the cost-effectiveness of increasing HCV case-finding among PWID by offering DBS testing in specialist addiction services or prisons as compared to using venepuncture. Design Cost-utility analysis using a dynamic HCV transmission model among PWID, including: disease progression, diagnosis, treatment, injecting status, incarceration and addition services contact. Setting UK. Intervention DBS testing in specialist addiction services or prisons. Intervention impact was determined by a meta-analysis of primary data. Primary and secondary outcome measures Costs (in UK £, £1=US$1.60) and utilities (quality-adjusted life years, QALYs) were attached to each state and the incremental cost effectiveness ratio (ICER) determined. Multivariate uncertainty and one-way sensitivity analyses were performed. Results For a £20 000 per QALY gained willingness-to-pay threshold, DBS testing in addiction services is cost-effective (ICER of £14 600 per QALY gained). Under the base-case assumption of no continuity of treatment/care when exiting/entering prison, DBS testing in prisons is not cost-effective (ICER of £59 400 per QALY gained). Results are robust to changes in HCV prevalence; increasing PWID treatment rates to those for ex-PWID considerably reduces ICER (£4500 and £30 000 per QALY gained for addiction services and prison, respectively). If continuity of care is >40%, the prison DBS ICER falls below £20 000 per QALY gained. Conclusions Despite low PWID treatment rates, increasing case-finding can be cost-effective in specialist addiction services, and in prisons if continuity of treatment/care is ensured.
Sub-band Knowledge Distillation Framework for Speech Enhancement

In single-channel speech enhancement, methods based on full-band spectral features have been widely studied. However, only a few methods pay attention to non-full-band spectral features. In this paper, we explore a knowledge distillation framework based on sub-band spectral mapping for single-channel speech enhancement. Specifically, we divide the full frequency band into multiple sub-bands and pre-train an elite-level sub-band enhancement model (teacher model) for each sub-band. These teacher models are dedicated to processing their own sub-bands. Next, under the teacher models' guidance, we train a general sub-band enhancement model (student model) that works for all sub-bands. Without increasing the number of model parameters and computational complexity, the student model's performance is further improved. To evaluate our proposed method, we conducted a large number of experiments on an open-source data set. The final experimental results show that the guidance from the elite-level teacher models dramatically improves the student model's performance, which exceeds the full-band model by employing fewer parameters.
Communications Between the Facial Nerve and the Vestibulocochlear Nerve, the Glossopharyngeal Nerve, and the Cervical Plexus

AbstractThe aim of this review is to elucidate the communications between the facial nerves or facial nerve and neighboring nerves: the vestibulocochlear nerve, the glossopharyngeal nerve, and the cervical plexus.In a PubMed search, 832 articles were searched using the terms “facial nerve and communication. ” Sixty-two abstracts were read and 16 full-text articles were reviewed. Among them, 8 articles were analyzed.The frequency of communication between the facial nerve and the vestibulocochlear nerve was the highest (82.3%) and the frequency of communication between the facial nerve and the glossopharyngeal nerve was the lowest (20%). The frequency of communication between the facial nerve and the cervical plexus was 65.2 ± 43.5%. The frequency of communication between the cervical branch and the marginal mandibular branch of the facial nerve was 24.7 ± 1.7%. Surgeons should be aware of the nerve communications, which are important during clinical examinations and surgical procedures of the facial nerves such as those communications involved in facial reconstructive surgery, neck dissection, and various nerve transfer procedures.
Transcription Factor OsTGA10 Is a Target of the MADS Protein OsMADS8 and Is Required for Tapetum Development1[OPEN]

The transcription factor OsTGA10, a target of OsMADS8, regulates tapetum development via direct binding to other tapetum-regulatory factors and to the regulatory regions of genes involved in tapetum development. This study aimed at elucidating regulatory components behind floral organ identity determination and tissue development. It remains unclear how organ identity proteins facilitate development of organ primordia into tissues with a determined identity, even though it has long been accepted that floral organ identity is genetically determined by interaction of identity genes according to the ABC model. Using the chromatin immunoprecipitation sequencing technique, we identified OsTGA10, encoding a bZIP transcription factor, as a target of the MADS box protein OsMADS8, which is annotated as an E-class organ identity protein. We characterized the function of OsTGA10 using genetic and molecular analyses. OsTGA10 was preferentially expressed during stamen development, and mutation of OsTGA10 resulted in male sterility. OsTGA10 was required for tapetum development and functioned by interacting with known tapetum genes. In addition, in ostga10 stamens, the hallmark cell wall thickening of the endothecium was defective. Our findings suggest that OsTGA10 plays a mediator role between organ identity determination and tapetum development in rice stamen development, between tapetum development and microspore development, and between various regulatory components required for tapetum development. Furthermore, the defective endothecium in ostga10 implies that cell wall thickening of endothecium is dependent on tapetum development.
Lipoxygenase metabolites induced expression of adhesion molecules and transendothelial migration of monocyte‐like HL‐60 cells is linked to protein kinase C activation

Studies have shown that, among lipoxygenase metabolites examined, 15(S)‐hydroperoxy‐5,8,11,13‐eicosa‐tetraenoic acid (15[S]‐HPETE), at micromolar concentrations, selectively causes injury to cultured endothelial cells. We investigated whether physiologically relevant concentrations of lipoxygenase metabolites affected the expression of cell adhesion molecules (CAMs) involved in the adhesion of leukocytes and/or the accumulation of leukocytes in the vascular endothelium, these being the initial events in endothelial cell injury. Among lipoxygenase metabolites, 15(S)‐HPETE and 12(S)‐HETE, at nanomolar concentrations, induced surface expression of a subset of cell adhesion molecules (CAM), ICAM‐1, ELAM‐1, and VCAM‐1, in human umbilical vein endothelial cells (HUVEC), which is associated with an increased binding activity of the transcription factor, NF‐κB, to the consensus motif common to the CAM genes in the HUVEC nuclear extracts. Furthermore, 15(S)‐HPETE (1 nM) caused a threefold increase in the rate of transendothelial migration of vitamin D3‐differentiated HL‐60 monocyte‐like cells and showed a thirtyfold increase in the phosphorylation of PECAM‐1, an adhesion molecule involved in endothelial cell‐cell adhesion. Both an antibody to PECAM‐1 and the protein kinase C inhibitor, GF 109203X, reduced 15(S)‐HPETE‐induced transmigration of monocyte‐like HL‐60 cells by approximately 75% and 85%, respectively. Treatment of HUVEC with a phosphatase inhibitor, calyculin A, augmented both the phosphorylation of PECAM‐1 and transmigration of monocyte‐like HL‐60 cells induced by 15(S)‐HPETE. Our results show that 15(S)‐HPETE, at physiological concentrations, induced activation of protein kinase C in HUVEC and leads to the phosphorylation of PECAM‐1, thus facilitating the migration of monocyte‐like HL‐60 cells across the endothelial cell monolayer. It is suggested that phosphorylation/dephosphorylation events in PECAM‐1 are important in regulating the trafficking of monocytes across the endothelial cell monolayer. © 1996 Wiley‐Liss, Inc.