Miracle-dz/UniFAR-FTUs huggingface dataset:
La Información como una Capacidad Organizacional: Incidencia en la Estrategia y Rendimiento del Negocio

La problematica principal que se aborda en esta presentacion es la definicion y vinculacion causal de la “habilidad organizativa de uso y administracion de la informacion” en el rendimiento organizacional. Su base conceptual se centra en a) la Direccion Estrategica, en particular en el Enfoque de Recursos y Capacidades; y b) el Enfoque Contingente, postulandose la necesidad de “ajuste” entre la estrategia de negocio y los “recursos y capacidades de informacion surgidos a partir de los SI/TIC” para la obtencion de un rendimiento organizacional superior. La contribucion principal de la investigacion, desde un punto de vista teorico, esta en la forma de una evaluacion empirica de un modelo de referencia que exhibe una relacion entre la “capacidad de informacion organizacional”, el rendimiento y la estrategia del negocio. Desde una perspectiva practica, la relacion entre los factores mencionados proveera de pistas a las empresas en como administrar la informacion para sostener y mejorar su rendimiento. Desde una perspectiva metodologica, se plantea la utilizacion de la tecnica estadistica de modelos de ecuaciones estructurales de forma de evaluar las relaciones postuladas.
The Glucocorticoid Receptor and RU 486 in Man

RU 486 is a prototype glucocorticoid antagonist with strong antiglucocorticoid activity in vitro and in vivo. Studies of its molecular mechanism of action have provided invaluable insights in the complex activation cascade of the GR itself. RU 486 effectively antagonizes glucocorticoids in most glucocorticoid-sensitive systems. Agonist effects, however, have been observed in some in vitro and in vivo systems, but remain the exception. In humans, administration of RU 486 causes generalized glucocorticoid resistance with high levels of cortisol compensating for the peripheral receptor blockade. This state is similar to that of patients with generalized familial glucocorticoid resistance. Because of its HPA axis stimulatory effects, RU 486 has limited chronic utility as an antiglucocorticoid. To date, the application of RU 486 can only be recommended in inoperable patients with ectopic ACTH secretion or adrenal carcinoma who have failed to respond to other treatments. The unusually long half-life of this drug also poses problems with titrating its dose within a therapeutic range. The development of a short-acting, selective glucocorticoid antagonist is therefore, a desirable goal of future research.
How can the clinical supervisor role be facilitated in nursing: a phenomenological exploration.

AIM To explore the nature of the nurse clinical supervisor role. BACKGROUND Although clinical supervision in nursing has been widely explored, few studies have considered the specific role of nurse clinical supervisors. METHOD A phenomenological approach was used to explore what it means to be a clinical supervisor. Focus groups interviews were conducted with 12 nurse clinical supervisors within one National Health Service (NHS) Trust. RESULTS Three main categories of themes that represented the essence of the clinical supervisors' role were uncovered. CONCLUSIONS The research demonstrated that nurses who undertake the clinical supervisor role are rarely offered guidelines for fulfilling the role. The findings reveal gaps in the structure of the clinical supervisor's role which could be hampering successful clinical supervision. IMPLICATIONS FOR NURSING MANAGEMENT The study adds to the existing evidence base and serves to inform managers of the nature of the nurse clinical supervisor role and how it could be better facilitated. The data shed light on the needs of nurse clinical supervisors who often adopt this role in addition to their other clinical and professional commitments. The findings indicate that managerial support in the form of prioritizing training and offering support mechanisms help nurses to effectively fulfil the clinical supervisor role.
Identification of Methionine as the Site of Covalent Attachment of a p-Benzoyl-Phenylalanine-containing Analogue of Substance P on the Substance P (NK-1) Receptor*

Previously we have been able to restrict the site of covalent attachment of a photolabile and radiolabeled derivative of substance P (SP), p-benzoylphenylalanine8-SP (Bpa8-SP), to residues 178-183 located on the second extracellular loop (E2) of the SP (NK-1) receptor (Boyd, N. D., Kage, R., Dumas, J. J., Krause, J. E., and Leeman, S. E. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 433-437). To ascertain the specific amino acid in this sequence that serves as the site of covalent attachment for 125I-Bolton-Hunter reagent (BH)-Bpa8-SP, we have employed here a novel solid-phase approach to cyanogen bromide cleavage of the photolabeled receptor followed by mass spectrometric analysis of a purified labeled fragment. SP receptors on transfected Chinese hamster ovary cells were photolabeled with isotopically diluted 125I-BH-Bpa8-SP. A membrane preparation of the photolabeled receptors was adsorbed onto C-18-derivatized silica gel and cleaved with cyanogen bromide. A single radiolabeled fragment containing 63% of the photoincorporated radioactivity was generated and purified by high performance liquid chromatography. Mass spectrometric analysis identified a single molecular ion with a molecular mass of 1751.4 ± 2, establishing that upon irradiation the bound photoligand forms a covalent link with the methyl group of a methionine residue at the peptide binding site. In view of our previous findings, this methionine is Met-181 on the primary sequence of the SP receptor.
Acquitting an APC: DCs found “not guilty” after trial by ablation

There is a large body of evidence demonstrating that DCs are the most efficient and specialized APCs for T‐cell priming, both in the context of host defense against pathogens and during the development of T‐cell‐mediated autoimmune responses; however, this concept is currently being challenged by a series of conflicting observations using genetically engineered mice in which DCs are either constitutively or inducibly ablated. In this issue of the European Journal of Immunology, Isaksson et al. [Eur. J. Immunol. 2012, 42: 2555‐2563] report the use of mice in which CD11chi cells can be ablated by injecting diphtheria toxin in vivo. The authors then induced EAE and found that, surprisingly, the mice were fully susceptible to the disease; thus, challenging the dogma that DCs are a mandatory APC population for the priming of autoimmune TH cells or T‐cell‐mediated immune responses. Here, we will analyze the authors’ findings in the context of observations made by others and critically discuss whether DCs can really be dismissed as crucial APCs.
Integration of Time Series Modeling and Wavelet Transform for Monitoring Nuclear Plant Sensors

Dynamic fluctuations of nuclear plant sensors contain information about their response characteristics and bandwidth features. The random fluctuations can be characterized by using auto-regression (AR) time-series models. These discrete-time models are then utilized to estimate time-domain and frequency-domain signatures. Prior to developing these models, the sensor measurements are enhanced by filtering both low-frequency and high-frequency components using wavelet transforms. The use of wavelet transform for signal conditioning results in minimum distortion of the signal bandwidth, and thus provides an effective approach for data pre-processing. This integrated approach is applied to plant data from a pressurized water reactor (PWR). Univariate AR models were established for several pressure transmitter data, and used to estimate response time parameters of sensors and their frequency spectra. The results of this integrated approach demonstrate the improvement in the sensor signature estimation compared to the direct use of plant measurements.
A Target-Ambitious Loom to the Discovery of Early Aspects Through Goal Clustering by Using Clustering Algorithm

Aspect-oriented code development plays a very important role in development and maintenance approach of code engineering across code development phases. However, in existing system the discovering of early aspects to better integration from demand continues to be a difficult issue. In this projected work , the experimentation has been created to propose a Goaldriven Early side approach (called GEA) to find AN early aspects by means that of a cluster formula in which relationships among goals and use cases are used efficiently to explore alikeness degrees of a cluster goals, and overall total communication degrees are formulate to check the validity of the formation of every cluster. Presenting early aspects not solely magnifies the goaldriven necessities modeling to handle intersectant the issues, however additionally provides interchangeably insights into the analysis and style of software development. Moreover, relationships among goals appeared numerically are a lot of informative to find early aspects and a lot of simply to be processed computationally than qualitative terms. a lot of secured MD5 (Message Digest) algorithm is to boot enforced to produce the higher authentication and identity checking services. Keywords— GEA, Cluster goals, Message Digest, Higher Authentication.
Prevention of primary cytomegalovirus infection in patients with hematologic malignancies by intensive white cell depletion of blood products

The effect of white cell depletion of red cells and platelet concentrates on the transmission of cytomegalovirus (CMV) was studied retrospectively in 150 patients treated intensively for acute leukemia or non‐Hodgkin's lymphoma. CMV infection was diagnosed on the basis of IgM and IgG antibody responses to CMV late antigen (CMV‐LA). Before cytoreductive therapy for their underlying disease, 59 patients were CMV seronegative and 91 were CMV seropositive. None of the 59 CMV‐seronegative patients showed persistent seroconversion 2 months after the cytoreductive treatment. The comparison group, consisting of 312 cardiac surgery patients, showed a significantly higher incidence of primary CMV infections: 10 of 86 (11.6%, p = 0.004). Twenty‐five percent of the CMV‐seronegative patients and controls had transient IgG antibodies to CMV‐LA without IgM antibodies, which is indicative of antibodies passively acquired via blood products. These results indicate that white cell‐poor blood products carry a very low risk, if any, of CMV transmission. The policy of transfusing white cell‐poor blood products provides a useful alternative to the selection of CMV‐seronegative donors.
In vivo MR-angiography for the assessment of aortic aneurysms in an experimental mouse model on a clinical MRI scanner: Comparison with high-frequency ultrasound and histology

Background MR-angiography currently represents one of the clinical reference-standards for the assessment of aortic-dimensions. For experimental research in mice, dedicated preclinical high-field MRI scanners are used in most studies. This type of MRI scanner is not available in most institutions. The aim of this study was to evaluate the potential of MR-angiography performed on a clinical MR scanner for the assessment of aortic aneurysms in an experimental mouse model, compared to a preclinical high-resolution ultrasound imaging system and histopathology. Methods All in vivo MR imaging was performed with a clinical 3T MRI system (Philips Achieva) equipped with a clinical gradient system in combination with a single-loop surface-coil (47 mm). All MR sequences were based on clinically used sequences. For ultrasound, a dedicated preclinical high-resolution system (30 MHz linear transducer, Vevo770, VisualSonics) was used. All imaging was performed with an ApoE knockout mouse-model for aortic aneurysms. Histopathology was performed as reference-standard at all stages of aneurysm development. Results MR-angiography on a clinical 3T system enabled the clear visualization of the aortic lumen and aneurysmal dilation at different stages of aneurysm development. A close correlation (R2 = 0.98; p < 0.001) with histological area measurements was found. Additionally, a good agreement between MR and ultrasound area measurements in systole (R2 = 0.91; p < 0.001) and diastole (R2 = 0.94; p < 0.001) were measured. Regarding interobserver reproducibility, MRI measurements yielded a smaller 95% confidence interval and a closer interreader correlation compared to ultrasound measurements (-0.37–0.46; R2 = 0.97 vs. -0.78–0.88; R2 = 0.87). Conclusion This study demonstrates that MR-angiography, performed on a clinical 3T MR scanner, enables the reliable detection and quantification of the aortic dilatation at different stages of aneurysm development in an experimental mouse model.
High responsivity SiGe heterojunction phototransistor on silicon photonics platform.

We report on a novel near infrared SiGe phototransistor fabricated by a standard silicon photonics foundry. The device is first investigated by simulations. The fabricated devices are characterized in terms of current-voltage characteristics at different optical power. Typical phototransistors exhibit 1. 55µm record responsivity at low optical power exceeding 232A/W and 42A/W at 5V and 1V bias, respectively. A differential detection scheme is also proposed for the dark current cancellation to significantly increase the device sensitivity.
The Business Value of Process Sharing in Supply Chains: A Study of RosettaNet

The research described in this paper builds on process theory and the resource-based view to examine the business value of process sharing in supply chains. Extending the two-stage model developed to define firm-level IT value, a measurement system is designed for assessing five business values resulting from process sharing: direct and indirect technological value, direct and indirect process value, and relationship value. To ensure that these business values can be fully realized on the firm level, the paper examines the relationship between them and firm performance and the moderating role of collaboration levels. An empirical study conducted in the context of the RosettaNet process-sharing initiative in the high-technology industry supply chain finds that (1) improving supply chain relationships can increase firm performance as much as business processes can; (2) improving indirect values can create greater firm performance than improving direct values, and (3) value conversion is more effective at high levels of collaboration. This valuation framework contributes to the literature by confirming the range of business values offered by process sharing and also by showing which value is of primary importance to firms in their business decisions. The findings will guide firms in identifying key value components, targeting those that can lead to higher firm performance, and enhancing collaboration levels to improve the value conversion.
Bone mineral density and urine calcium excretion among subjects with and without nephrolithiasis.

BACKGROUND Bone mineral density (BMD) is reduced among patients with idiopathic hypercalciuria (IH) and nephrolithiasis. To disentangle effects of diet, stone formation, and physiology upon BMD, we studied vertebral and femoral neck BMD among relatives of hypercalciuric stone formers, and contrasted those with to those without stones. METHODS Among 59 subjects from 11 families, vertebral and femoral neck BMD, diet calcium intake, urine excretions of calcium, sodium, ammonium, titratable acid, sulfate, urea nitrogen, and serum levels of calcitriol and markers of bone turnover were studied. RESULTS Stone formers (SF) consumed less calcium than non-stone formers (NSF). Spine and femoral neck BMD z-scores varied inversely with urine calcium loss and urine ammonium excretion among SF but not NSF. No correlations of BMD z-score were found for bone markers, calcitriol, or any of the other measurements. CONCLUSION SF consumed less calcium, presumably to prevent more stones, and displayed a bone mineral responsiveness to calcium loss and ammonium excretion not present among NSF, who ate more calcium. Lowered calcium consumption in IH, perhaps in response to stone formation, alters bone responses in a direction that can predispose to mineral loss and eventual fracture.
Quantification of sarcomere length distribution in whole muscle frozen sections

ABSTRACT Laser diffraction (LD) is a valuable tool for measuring sarcomere length (Ls), a major determinant of muscle function. However, this method relies on few measurements per sample that are often extrapolated to whole muscle properties. Currently it is not possible to measure Ls throughout an entire muscle and determine how Ls varies at this scale. To address this issue, we developed an actuated LD scanner for sampling large numbers of sarcomeres in thick whole muscle longitudinal sections. Sections of high optical quality and fixation were produced from tibialis anterior and extensor digitorum longus muscles of Sprague–Dawley rats (N=6). Scans produced two-dimensional Ls maps, capturing >85% of the muscle area per section. Individual Ls measures generated by automatic LD and bright-field microscopy showed excellent agreement over a large Ls range (ICC>0.93). Two-dimensional maps also revealed prominent regional Ls variations across muscles. Summary: An actuated laser diffraction scanner for sampling large numbers of sarcomeres in whole muscle sections produces two-dimensional sarcomere length maps and shows excellent agreement with microscopy methods.
Effect of ascorbic acid supplementation on nitric oxide metabolites and systolic blood pressure in rats exposed to lead

Background: Extended exposure to low levels of lead causes high blood pressure in human and laboratory animals. The mechanism is not completely recognized, but it is relatively implicated with generation of free radicals, oxidant agents such as ROS, and decrease of available nitric oxide (NO). In this study, we have demonstrated the effect of ascorbic acid as an antioxidant on nitric oxide metabolites and systolic blood pressure in rats exposed to low levels of lead. Materials and Methods: The adult male Wistar rats weighing 200-250 g were divided into four groups: control, lead acetate (receiving 100 ppm lead acetate in drinking water), lead acetate plus ascorbic acid (receiving 100 ppm lead acetate and 1 g/l ascorbic acid in drinking water), and ascorbic acid (receiving 1 g/l ascorbic acid in drinking water) groups. The animals were anesthetized with ketamin/xylazine (50 and 7 mg/kg, respectively, ip) and systolic blood pressure was then measured from the tail of the animals by a sphygmomanometer. Nitric oxide levels in serum were measured indirectly by evaluation of its stable metabolites (total nitrite and nitrate (NOχ)). Results: After 8 and 12 weeks, systolic blood pressure in the lead acetate group was significantly elevated compared to the control group. Ascorbic acid supplementation could prevent the systolic blood pressure rise in the lead acetate plus ascorbic acid group and there was no significant difference relative to the control group. The serum NOχ levels in lead acetate group significantly decreased in relation to the control group, but this reduction was not significantly different between the lead acetate plus ascorbic acid group and the control group. Conclusion: Results of this study suggest that ascorbic acid as an antioxidant prevents the lead induced hypertension. This effect may be mediated by inhibition of NOχ oxidation and thereby increasing availability of NO.
Change of the structure and the digestibility of myofibrillar proteins in Nanjing dry-cured duck during processing.

BACKGROUND To investigate the change of bioavailability and structure of myofibrillar proteins during Nanjing dry-cured duck processing, carbonyl content, sulfhydryl (SH) group, disulfide (SS) group, sodium dodecyl sulfate polyacrylamide gel electrophoresis, surface hydrophobicity, secondary structures and in vitro digestibility were determined. RESULTS During processing, carbonyl content and surface hydrophobicity increased; SH turned into SS group; α-helix turned into β-sheet and random coil fractions. Protein degradation occurred during dry-curing and drying-ripening stages. The in vitro digestibility of pepsin and pancreatic proteases increased during the salt curing stage and decreased during the drying-ripening stage. CONCLUSION The increase of digestibility could be attributed to the mild oxidation, degradation and unfolding of proteins while the decrease of digestibility was related to the intensive oxidation and aggregation of proteins. Protein degradation was not a main factor of digestibility during the drying-ripening stage. Results demonstrated that the bioavailability loss of myofibrillar proteins in Nanjing dry-cured duck occurred during the stage of drying-ripening instead of curing. © 2017 Society of Chemical Industry.
Balancing needs: The role of motivations, meanings and relationship dynamics in the experience of informal caregivers of people with dementia

This paper investigates how meaning, motivation and relationship dynamics influence the caregivers’ subjective experience of caregiving. We interviewed 12 family caregivers of relatives with dementia. We analysed transcripts of these interviews using interpretative phenomenological analysis. Six key themes emerged from the analysis, which were encompassed under an overarching theme of ‘balancing needs’. This describes the caregivers’ constant struggle to balance their own needs against those of their relative, which created a series of dilemmas. These dilemmas emerged from the desire to try to preserve the caregivers’ relationship with their relative, while recognising that this relationship was changing. The caregivers’ relationship with their relative influenced the caregivers’ motivations to provide care and gave caregiving meaning. Although caregivers were motivated to provide care the battle to balance needs meant that the caregivers recognised there might come a time when they may need to cease caregiving.
Genetic engineering in the Precambrian: structure of the chicken triosephosphate isomerase gene

We report the sequence of the single chicken triosephosphate isomerase gene and its flanking regions. The 3-kilobase-long gene is composed of seven similarly sized exons and six introns. By using crystallographic and sequence data, we argue that this ancient gene was originally assembled from the genetic antecedents of exons.
Asset Pricing with Dynamic Labor Contracts ∗

I study asset prices in a two-agent production economy in which the worker has private information about her labor productivity. The shareholder offers an incentive compatible long-term labor contract, which partially insures the worker against labor income risk. I compare the model’s performance to settings with a competitive labor market, and with static labor contracts. My model successfully matches both asset returns data and businesscycle features, including a countercyclical and high equity premium, a low risk-free rate, procyclical labor input, and countercyclical labor share. The results highlight that the dynamic contracting feature in labor relations is quantitatively important in determining asset prices. JEL Classification: D82, D86, E44, G12