Miracle-dz/UniFAR-FTUs huggingface dataset:
Inferring individual daily activities from mobile phone traces: A Boston example

Understanding individual daily activity patterns is essential for travel demand management and urban planning. This research introduces a new method to infer individuals’ activities from their mobile phone traces. Using Metro Boston as an example, we develop an activity detection model with travel diary surveys to reveal the common laws governing individuals’ activity participation, and apply the modeling results to mobile phone traces to extract the embedded activity information. The proposed approach enables us to spatially and temporally quantify, visualize, and examine urban activity landscapes in a metropolitan area and provides real-time decision support for the city. This study also demonstrates the potential value of combining new “big data” such as mobile phone traces and traditional travel surveys to improve transportation planning and urban planning and management.
Discovery of new biomarkers for atrial fibrillation using a custom-made proteomics chip

Background Apart from several established clinical risk factors for atrial fibrillation (AF), a number of biomarkers have also been identified as potential risk factors for AF. None of these have so far been adopted in clinical practice. Objective To use a novel custom-made proteomics chip to discover new prognostic biomarkers for AF risk. Methods In two independent community-based cohorts (Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (978 participants without AF, mean age 70.1 years, 50% women, median follow-up 10.0 years) and Uppsala Longitudinal Study of Adult Men (ULSAM) (n=725, mean age 77.5 years, median follow-up 7.9 years)), ninety-two plasma proteins were assessed at baseline by a proximity extension assay (PEA) chip. Of those, 85 proteins showed a call rate >70% in both cohorts. Results Thirteen proteins were related to incident AF in PIVUS (148 events) using a false discovery rate of 5%. Of those, five were replicated in ULSAM at nominal multivariable p value (123 events, N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), fibroblast growth factor 23 (FGF-23), fatty acid-binding protein 4 (FABP4), growth differentiation factor 15 (GDF-15) and interleukin-6 (IL-6)). Of those, NT-pro-BNP and FGF-23 were also associated with AF after adjusting for established AF risk factors. In a prespecified secondary analysis pooling the two data sets, T-cell immunoglobulin and mucin domain 1 (TIM-1) and adrenomedullin (AM) were also significantly related to incident AF in addition to the aforementioned five proteins (Bonferroni-adjustment). The addition of NT-pro-BNP to a model with established risk factors increased the C-statistic from 0.605 to 0.676 (p<0.0001). Conclusions Using a novel proteomics approach, we confirmed the previously reported association between NT-pro-BNP, FGF-23, GDF-15 and incident AF, and also discovered four proteins (FABP4, IL-6, TIM-1 and AM) that could be of importance in the development of AF.
Protection of Piglets against Edema Disease by Maternal Immunization with Stx2e Toxoid

ABSTRACT Edema disease (ED) in piglets is caused by Shiga toxin Stx2e-producing Escherichia coli. We show that a genetically disarmed Stx2e toxoid is a safe antigen that generates antiserum protecting piglets against the Stx2e toxin. Immunization of suckling piglets with the Stx2e toxoid was safe, had no adverse effects on growth of the piglets, and resulted in effective prevention of edema disease clinical symptoms after challenge with the Stx2e toxin. Our data showed that maternal immunity against the Stx2e toxoid can be transmitted from the vaccinated sows to the piglets via the colostrum. Very high levels of Stx2e-specific serum antibodies persisted in these piglets until 1 month postweaning, bridging the critical period in which the weaned piglets are most susceptible to edema infection. Challenge with Stx2e toxin resulted in clinical signs of edema disease and death of all control piglets from nonimmunized sows, whereas none of the piglets from immunized sows developed clinical signs of ED.
Ownership and Innovation during Economic Development: Corporate Ownership and Strategy Formation in China

Innovation is critical to organizational survival, competitive advantage, and economic development. Yet the process by which innovative strategic behavior occurs is not well understood. This paper takes advantage of rapidly changing corporate governance structures and environmental conditions during China's economic transition to explore the role of corporate ownership in shaping firm innovation. We argue that managers draw on internal strengths within external constraints to develop strategies and that the nature of corporate ownership determines the degree to which internal or external factors are salient. We capitalize on differences between Chinese state-owned enterprises (SOEs) and collective enterprises and other non-state firms (CNFs) in the adoption of firm strategies during transition. Analyzing data from 1994 to 1999 on 800 Chinese firms, we study the effect of ownership type on the adoption of four key organizational innovations and identify major strategic groups that developed during reform. The findings provide important insight into the role of corporate governance in influencing strategy formation and adaptation, outcomes that are increasingly important in all economies.
Organizational responsibility: Doing good and doing well.

The goals of this chapter are to introduce organizational responsibility research and practice to the field of industrial and organizational (I/O) psychology and to encourage I/O psychology researchers and practitioners to embrace organizational responsibility in their research and practice. Although its definition is elaborated in detail later in the chapter, organizational responsibility is defined as context-specific organizational actions and policies that take into account stakeholders’ expectations and the triple bottom line of economic, social, and environmental performance. In contrast with other topics included in this handbook, organizational responsibility does not seem to be a topic that receives much attention in the literature of mainstream I/O psychology, or even psychology in general. To assess the accuracy of this assertion, I conducted a search in January 2009 using the PsycINFO database and the key words corporate responsibility in all titles and abstracts. The review period covered all items (i.e., books, collections, journals, book chapters, dissertations, conference proceedings, editorials, encyclopedias, handbooks, and textbooks) in all languages included in PsycINFO until that date. There were 52 hits. However, only two of these were for items published in psychology journals (Dumas, 2007; Konczak, 2005). Moreover, neither of these items reported original research; instead, they were book reviews. The remaining 50 items were books, chapters, dissertations, and articles published outside of the field of psychology in journals such as Business Ethics: A European Review, Journal of Business Ethics, Corporate Communications, Journal of Management Development, Electronic Journal of Business Ethics and Organization Studies, and Corporate Reputation Review. I conducted the same search on the Business Source Premier database, and the result was 1,917 hits. Of this total, 757 items were articles published in academic journals; 486 were published in magazines and other periodicals, such as The Economist, Fortune, and Supply Management; 547 appeared in trade publications, such as Accountancy, Communication World, Marketing Magazine, and Money Management; and 127 appeared in other sources, such as books. Why this difference in publication rates in I/O psychology compared with other organizational studies disciplines? There are at least four reasons. First, organizational responsibility is an issue that is studied typically at the organizational level of analysis. Although it has shifted its emphasis to include the group level of analysis, most I/O psychology research still addresses primarily the individual level of analysis. In fact, an examination of the chapters included in this handbook suggests that the majority of topics address issues that have been studied primarily at the individual level of analysis. Second, related to the level of analysis reason, the terms organizational responsibility and corporate responsibility are not labels typically used in I/O psychology research. However, because of the interest in the individual
A Comparison of Underwriting Decision Making Between Telematics-Enabled UBI and Traditional Auto Insurance

Because of telematics-enabled UBI (usage-based insurance), real drivingÂ information can be collected and provided to underwriters. It promises moreÂ efficient pricing of risks, with widespread benefits expected to accrue to insurers,Â consumers and society. From the perspective of auto insurance underwriters,Â compare to the driving data collected by a traditional auto insurance applicationÂ form , the underwriting data collected from a telematics devices more effective orÂ not is a question and to answer. By employing prior literature reviewing and greyÂ relational analysis, this study found most of driving behavior data collected fromÂ telematics devices is very helpful for auto insurance underwriting, someÂ traditional data collected by an application form is still necessary for underwritersÂ to make a well underwriting decision. The implication is, in order to improve theÂ effective of an underwriting decision making, insurance companies need to takeÂ advantage of IoT(Internet of Things) tech to collect more helpful underwritingÂ data as well as adjust their underwriting policy accordingly.JEL classification numbers: O32Keywords: usage-based insurance, auto insurance, telematics, Underwriting
Diseases of the central nervous system. Relief of pain: headache, facial neuralgia, migraine, and phantom limb.

Tension is probably the commonest cause of headache. Ordinary analgesics, aspirin (0 3-0 9 g) or compound preparations, should be tried first, although headache is a common cause of analgesic abuse. Chronic treatment with aspirin, phenacetin, or paracetamol may lead to nephritis or peptic ulceration. Minor tranquillisers, such as chlordiazepoxide (5-30 mg daily), diazepam (2-30 mg daily), or phenobarbitone (30-120 mg daily) occasionally relieve headaches resulting from various stresses, and tricyclic antidepressant drugs such as dothiepin (50-150 mg at night) sometimes give dramatic relief from chronic tension headache in depressed patients. Major tranquillisers and narcotic analgesics should not be used to treat patients with tension headache. A simple explanation of the cause of this is often far more effective treatment than the prescription of the latest triumph of neuropharmacological research.
Long-Term Outcome after Ischaemic Stroke/Transient Ischaemic Attack

During the first 30 days after a stroke, the case fatality is about 25% and the major cause of death is the index stroke and its sequelae. The most consistent predictor of 30-day mortality after stroke is stroke severity. Other predictors include increasing age, a history of previous stroke, cardiac failure, and a high blood glucose concentration and white blood cell count. Other less common, but important, causes of early mortality are recurrent ischaemic stroke and a coronary event. The risk of a recurrent cerebrovascular event is highest in the first month (4%) and year (12%) after a stroke and transient ischaemic attack (TIA), probably reflecting the presence of active, unstable atherosclerotic plaque. Thereafter, the risk of a recurrent cerebrovascular event falls to about 5% per year, similar to the risk of a coronary event. During years 1–5 after a TIA and ischaemic stroke, cardiovascular disease increasingly becomes the major cause of death, reflecting the generalized nature of atherothrombosis, the most common cause of the index stroke. The most robust predictor of death within 1–5 years after stroke is increasing age, closely followed by cardiac failure. Additional baseline predictors of longer-term mortality include a history of previous symptomatic atherothrombosis (TIA, ischaemic stroke, peripheral arterial disease, and early-onset ischaemic heart disease), risk factors for atherothrombosis (smoking), other heart diseases (cardiac failure, atrial fibrillation) and increasing stroke severity. Lacunar syndromes can be predictive of relative longevity. At 5 years after stroke, survival is about 40%, and about half of survivors are disabled and dependent. The most robust predictors of disability at 5 years after stroke are increasing age, stroke severity, and recurrent stroke. The most powerful predictor of early recurrent stroke (within 30 days after stroke) is an atherosclerotic ischaemic stroke caused by large-artery atherosclerosis with >50% stenosis, whereas the strongest predictor of stroke recurrence over 5 years is diabetes. Other predictors of recurrent stroke include increasing age, previous TIA, atrial fibrillation, high alcohol consumption, haemorrhagic index stroke, and hypertension at discharge. The clinical implication of these findings is that strategies for optimizing long-term outcome after TIA and stroke should be directed toward reducing the high risk of recurrent stroke and coronary events by removing/recanalizing the symptomatic atherosclerotic plaque, controlling the underlying causal vascular risk factors, and administering long-term, effective antiplatelet therapy.
GAD65 antibody epitope patterns of type 1.5 diabetic patients are consistent with slow-onset autoimmune diabetes.

Type 1.5 diabetes (1) is characterized by rapid loss of β-cell function, failure of oral agents, and acquirement of insulin requirement (2,3). These patients have islet cell antibodies (ICAs), GAD65 autoantibodies (GAD65Abs) (4,5,6), or both, indicating an underlying autoimmune pathogenesis. Therefore, the question of whether type 1.5 diabetes represents a separate clinical disease or a slowly progressive form of type 1 diabetes has been raised (7,8). The aim of the present study was to investigate whether GAD65Ab epitopes in type 1.5 diabetic patients differ from those found in type 1 diabetic patients and other GAD65Ab-positive phenotypes. Type 1.5 diabetic patients ( n = 34) were identified as GAD65Ab-positive type 2 diabetic …
Same Words, Different Meanings: Are Basic IS/IT Concepts Our Self-Imposed Tower Of Babel?

This article began as a response to an exchange of letters concerning the need for more vs. less user participation in IS projects. It grew into an exploration of whether and how ten 1999 CAIS articles use basic IS/IT terms with different meanings and connotations related to the different perspectives of their authors. The article characterizes differences between an IT perspective and a business perspective and categorizes the ten articles accordingly. It then presents numerous quotes from the articles to illustrate differences across the articles in terms of their use of eight basic concepts: system, user, stakeholder, IS project, implementation, reengineering, requirements, and solution. To help understand the differences and their significance, the article makes extensive use of distinctions between work systems, information systems, and projects. When applied to the articles these distinctions raise questions such as whether the term “system” refers to a work system, information system, or software, and whether the term “user” refers to hands-on users, people who receive information, or managers whose organizations use information systems. An underlying theme throughout is that the lack of conscious attention to the meaning of basic terms and points of reference may be a significant impediment to effective communication and to our ability to make sense out of research findings and even journalistic anecdotes about what seemed to work or not work in particular situations.
Performance of Family Business and Non Family Business Companies Listed on the Stock Exchange of Thailand

There are few studies about Family Business in Thailand. Consequently, there is no research about Family Business Performance in Thailand. This research is aimed at measuring the performance of Family Business listed on Stock Exchange of Thailand. The definitions of Family Business are categorized by Wonglorsaichon and Bangchuenvijit(2008) with three perspectives of Family Business. The methodology for this research is Fortune®500 DEA Model which comprises three stages of calculation. With the information taken from 294 listed companies in 2009, the findings are that from the four highest rank companies, there are three Family Business companies that belong to the first definition and two Family Business companies to the third and fourth definitions.
Amygdalar activation alters the hippocampal GABA system: “Partial” modelling for postmortem changes in schizophrenia

Abnormalities in amygdala and hippocampus have been shown to coexist in schizophrenia (SZ). In the hippocampus, compelling evidence suggests that a disruption of GABA neurotransmission is present mainly in sectors CA4, CA3, and CA2. The amygdala sends important inputs to the hippocampus and is also believed to have a defective GABA system in schizophrenia. To explore the possibility that changes in the hippocampal GABAergic system could be related to an increased inflow of activity originating in the amygdala, a “partial” animal model has been developed. In awake, freely moving, rats a GABAA receptor antagonist was infused locally into the basolateral nuclear complex of the amygdala (BLn). Within 2 hours, a decreased density of both the 65‐ and 67‐kDa isoforms of glutamate decarboxylase (GAD65 and GAD67) ‐immunoreactive (IR) terminals was detected on neuron somata in sectors CA3 and CA2, but not in CA1, CA4, or dentate gyrus. An increase of GAD67‐IR somata was also found in the dentate gyrus and CA4. In anterograde tracer studies, amygdalo‐hippocampal projection fibers were exclusively found in CA3 and CA2, but not CA1. Taken together, these results indicate that activation of amygdalo‐hippocampal afferents is associated with the induction of significant changes in the GABA system of the hippocampus, with a subregional distribution that is remarkably similar to that found in SZ. Under pathologic conditions, an excessive discharge of excitatory activity emanating from the amygdala could be capable of altering inhibitory modulation along the trisynaptic pathway. This mechanism may potentially contribute to disturbances of GABAergic function in the major psychoses. Such “partial” rodent modelling provides an important strategy for deciphering the effect of altered cortico‐limbic circuits in SZ. J. Comp. Neurol. 431:129–138, 2001. © 2001 Wiley‐Liss, Inc.
REAKSI PASAR TERHADAP PENGUMUMAN EMPLOYEE STOCK OWNERSHIP PROGRAM

In Indonesia, the increasing of Employee Stock Ownership Program (ESOP) was relative known new, so it needed any evidence for the market reaction in Indonesia stock exchange. From the latest problem, the purpose of this research was to know how the market reaction for the announcement of ESOP in Indonesia Stock Exchange. Samples on this research were the companies which were listed in BEI that had announced ESOP for period January 1, 2000 – December 31, 2010. Analysis technique on hypotesis test related with market reaction for ESOP announcement was done by event study to calculate abnormal return. Research result showed that market tended to ignore ESOP announcement. And it meant that ESOP announcement was not considered as a signaling, which gave a good information for the investor in Indonesia to achieve profit.
A comparative study of raised-floor and hard-floor configurations in an air-cooled data centre

The thermal performance of an air-cooled data centre with raised-floor and hard-floor configurations are compared with respect to the room and ceiling return strategies. The supply heat index, rack cooling index and number of racks that exceed the maximum recommended and allowable rack inlet air temperature according to ASHRAE's thermal guidelines, are used to evaluate the thermal performance. Numerical simulations are conducted to obtain thermal and velocity fields. Results show that using a ceiling return strategy for the return of hot exhaust air to the CRACs gives a better thermal performance of the data centre, for both raised and hard-floor strategy as against the room return. The paper also addresses an important limitation of the supply heat index performance metric.
CD45 is required for type I IFN production by dendritic cells

CD45 is a leukocyte tyrosine phosphatase, essential for normal immune responses. We have studied the function of splenic dendritic cells of CD45+/+, CD45–/–, CD45RABC and CD45RO transgenic mice. We show that there are increased numbers of plasmacytoid dendritic cells in CD45–/– mice. DC of all mice are capable of responding to lymphocytic choriomeningitis virus (LCMV) infection by up‐regulation of MHC and costimulatory molecules. DC of CD45–/– mice have an impaired capacity to produce type I interferons in response to LCMV infection in vivo. These data indicate that lack of CD45 expression in DC has a profound effect on their function. This is largely restored by CD45RABC or CD45RO transgenes.
TGF-beta-1 up-regulates cyclin D1 expression in COLO-357 cells, whereas suppression of cyclin D1 levels is associated with down-regulation of the type I TGF-beta receptor.

Transforming growth factor-beta1 (TGF-beta1) inhibits cell growth in susceptible cells by interacting with a family of protein kinases that control cell cycle progression. In the present study, we investigated the effects of TGF-beta1 on cyclin D1 expression and activity in COLO-357 human pancreatic cancer cells. TGF-beta1 increased cyclin D1 mRNA and protein levels. Nuclear runoff transcription and protein synthesis inhibition by cycloheximide revealed that this increase was, in part, due to increased cyclin D1 mRNA synthesis. Despite its stimulatory effects on cyclin D1 levels, TGF-beta1 inhibited cyclin D1-associated kinase activity and the growth of COLO-357 cells. Furthermore, suppression of cyclin D1 expression with a cyclin D1 antisense cDNA resulted in loss of TGF-beta1-mediated growth inhibition in association with reduced induction of cyclin D1, p21(C)(ip)(1) and plasminogen activator inhibitor-1 (PAI-1). Concomitantly, there was a marked decrease in the levels of the type I TGF-beta receptor (TbetaRI). Our findings suggest that in some cell types cyclin D1 expression may be important for TGF-beta1-mediated signaling and that cyclin D1 may be involved in the transcriptional regulation of TbetaRI.