Miracle-dz/UniFAR-FTUs huggingface dataset:
Above the Epitranscriptome: RNA Modifications and Stem Cell Identity

Sequence databases and transcriptome-wide mapping have revealed different reversible and dynamic chemical modifications of the nitrogen bases of RNA molecules. Modifications occur in coding RNAs and noncoding-RNAs post-transcriptionally and they can influence the RNA structure, metabolism, and function. The result is the expansion of the variety of the transcriptome. In fact, depending on the type of modification, RNA molecules enter into a specific program exerting the role of the player or/and the target in biological and pathological processes. Many research groups are exploring the role of RNA modifications (alias epitranscriptome) in cell proliferation, survival, and in more specialized activities. More recently, the role of RNA modifications has been also explored in stem cell biology. Our understanding in this context is still in its infancy. Available evidence addresses the role of RNA modifications in self-renewal, commitment, and differentiation processes of stem cells. In this review, we will focus on five epitranscriptomic marks: N6-methyladenosine, N1-methyladenosine, 5-methylcytosine, Pseudouridine (Ψ) and Adenosine-to-Inosine editing. We will provide insights into the function and the distribution of these chemical modifications in coding RNAs and noncoding-RNAs. Mainly, we will emphasize the role of epitranscriptomic mechanisms in the biology of naïve, primed, embryonic, adult, and cancer stem cells.
Maximum‐likelihood synchronization and channel estimation with multiuser detection in GFDMA

Accurate estimation and correction of channel distortions and carrier frequency offset (CFO) are of a great importance in any multicarrier communication system. Hence, in this paper, we propose data‐aided CFO and channel estimation techniques for both multiuser uplink and downlink of the generalized frequency division multiple access (GFDMA). Our proposed solutions jointly estimate the CFO and channel responses based on the maximum‐likelihood criterion. To simplify the implementation of the proposed estimation algorithms, we suggest a preamble composed of two similar Zadoff‐Chu training sequences in a generalized frequency division multiplexing block. It is worth mentioning that our proposed technique can estimate both integer and fractional CFO values without any limitation on the acquisition range of CFO. In the uplink phase, each user aligns its carrier frequency with the base station using the estimated CFO in the downlink. However, the CFO estimates may get outdated for the uplink transmission. Thus, residual CFOs may still remain in the received signal at the base station. While being trivial in the downlink, CFO correction is a challenging task in the uplink. Thus, we also propose a joint CFO correction and channel equalization technique for the uplink of GFDMA systems. Finally, we evaluate our proposed estimation and correction algorithms in terms of estimation mean square error and bit error rate performance through simulations.
When Sentry Goes Stealing: An Information Systems Security Case Study in Behavioural Context

In this paper we describe a case where the top management of a small holding company is involved in a love-hate relationship with its own IT department. The top management firmly believes that IT staff is involved in leaking out company’s secrets. However, having no expertise in IT and even lesser grasp on the complexity of IT architecture resulting from recent mergers and acquisition, the top management finds itself crucially dependent on its IT systems, yet unable to trust them fully. The theories of deterrence and reasoned action are used to explain the otherwise objectionable behaviour of the perpetrator.
Nondipping pattern on 24-h ambulatory blood pressure monitoring is associated with left ventricular hypertrophy in chronic kidney disease

Background Few studies have assessed the role of 24-h ambulatory blood pressure monitoring (ABPM) in adults with nondialysis chronic kidney disease (CKD). We examined the potential determinants of left ventricular hypertrophy (LVH) and mass index (LVMI) in this population. Participants and methods We carried out a cross-sectional study on 69 stage 3b-5 CKD adults who had ABPM and transthoracic echocardiography performed simultaneously. Hypertension (HT) was defined as 24 h blood pressure (BP) of at least 130/80 mmHg. ABPM parameters considered were BP dipping status, BP load, and the BP night-time/daytime ratio. We performed stepwise backward multivariate linear and logistic regression to assess the determinants of LVH and LVMI. ABPM parameters were considered the main independent variables, whereas HT, angiotensin-converting enzyme inhibitor/angiotensin II receptor antagonist use, glomerular filtration rate of less than 30 ml/min/1.72 m2, diabetes, smoking, age, sex, hemoglobin, and parathyroid hormone levels were considered covariates. Results LVH was present in 22 (31.8%) patients. In linear regression analysis, systolic [&bgr;=−13.8, 95% confidence interval (CI)=−26.3 to −1.3, P=0.031] and mean (&bgr;=−13.5, 95% CI=−25.7 to −1.2, P=0.031) nondipping status was associated with increased LVMI. BP load and night-time/daytime ABPM ratio were not associated with LVMI. In logistic regression analysis, systolic nondipping status (odds ratio=0.27, 95% CI=0.08–0.91, P=0.036) was associated with LVH. Among covariates, estimated glomerular filtration rate of less than 30 ml/min/1.72 m2 and HT were associated with LVH and increased LVMI. At 1-year follow-up, mean nondipping status on the initial ABPM remained associated significantly with increased LVMI (&bgr;=−19.8, 95% CI=−36.6 to −3.0, P=0.022). Conclusion These data confirm the high incidence of LVH among nonrenal replacement therapy CKD patients and suggest that the nondipping phenomenon on ABPM is associated independently with LVH and increased LVMI in this population.
Investigation between Performances of Free Space Optical Communication Links Under Atmospheric Turbulence

—Free Space Optics (FSO) is an emerging field that includes exclusive features of photonics. Optical carriers are used to deliver data in ultraviolet, visible and infrared bands respectively. It establishes a significant link in either terrestrial or ground to water or ground to space. However, as long as its demand is concerned, their performance is bound by some important factors that are needed to be discussed. In this review, focus is to investigate about the major gaps present as obstacles in the way of conceiving an optimized FSO link. This paper deals with the major contributions achieved in FSO as well as the impairments that are needed to be resolve for the establishment of FSO link. Major outcome parameters are discussed as BER performance, optimization of outage capacity, different modulation techniques, enlargement of beam coverage, spatial diversity, mitigation techniques etc. that directly deals with the performance of transmitting, channeling and receiving part of the FSO system respectively.
Evaluation of Total Salivary Secretory Immunoglobulin A and Mi/fans-specific SIgA among Children having Dissimilar Caries Status.

INTRODUCTION The occurrence of dental caries has become quite a common phenomenon nowadays. The varying levels of salivary secretory immunoglobulin A (SIgA) usually determine the progression of caries. The present study was aimed to determine the correlation between SIgA and mutans-specific antigen SIgA in children having different caries status. Scanning electron microscopic analysis was also completed to correlate the results. MATERIALS AND METHODS This study comprised 60 subjects, who were divided into three groups depending on caries status. In all, saliva was collected to determine the level of SIgA and mutans-specific antigen SIgA using enzyme linked immunosorbent assay (ELISA). The World Health Organization (WHO) criteria and method were used to evaluate dental caries. Bradford reagent was used to evaluate the levels of protein in the antigen. Furthermore, 20 sections of enamel were randomly obtained to estimate the severity of caries development among groups. RESULTS Categorical characteristics among all groups were compared by basic statistical analysis and Chi-squared test. Mean age (years) was found to be 9.214 ± 2.28, 9.5 ± 2.51, and 10.2 ± 2.35 in groups I, II, and III respectively. Mutans-specific IgA level (|jg/mL) was 34.63 ± 7.46, 28.24 ± 4.52, and 23.56 ± 1.62 in groups I, II, and III respectively. Total SIgA (jg/mL) was 142.53 ± 22.4, 186.10 ± 24.70, and 214.8 ± 27.56 in groups I, II, and III respectively. Caries index was 6.74 ± 2.16, 2.32 ± 0.86, and 0 ± 0 in groups I, II, and III respectively. CONCLUSION Immunoglobulin A is dominantly present in saliva and it plays a significant role in prevention of dental caries. Hence, dental caries is more likely to develop in subjects with low level of salivary IgA (high caries index). CLINICAL SIGNIFICANCE A low level of IgA may be associated with a high risk of developing dental caries. This association may possibly be useful in predicting the future caries status. Accordingly, suitable caries-preventive measures can be selected and employed.
In‐text function of author self‐citations: Implications for research evaluation practice

Author self‐citations were examined as to their function, frequency, and location in the full text of research articles and compared with external citations. Function analysis was based on manual coding of a small dataset in the field of library and information studies, whereas the analyses by frequency and location used both this small dataset and a large dataset from PubMed Central. Strong evidence was found that self‐citations appear more likely to serve as substantial citations in a text than do external citations. This finding challenges previous studies that assumed that self‐citations should be discounted or even removed and suggests that self‐citations should be given more weight in citation analysis, if anything.
Indocyanine green-mediated photothermal therapy in treatment of chronic periodontitis: A clinico-microbiological study

Background: Photodynamic therapy (PDT) has developed as an alternative treatment modality in periodontitis patients. Different photosensitizers used over the years have shown contradictory results. Thus, recently indocyanine green (ICG)-mediated photothermal therapy has emerged for the treatment of chronic periodontitis. Aim: The present study aimed at comparing and evaluating the effects of photothermal therapy using ICG in the treatment of chronic periodontitis with scaling and root planing (SRP). Materials and Methods: This was a randomized, controlled, clinical trial where fifty participants were equally divided into two groups, i.e., control group (SRP) and test group (SRP + photothermal therapy). Clinical parameters were evaluated at baseline and 6-month follow-up. These were plaque index (PI), bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL). Microbiological analysis of plaque sample was also done to check for anaerobic mixed flora. Results: Significant reduction was seen in PD, CAL, and BOP in the test group as compared to control group after 6 months (P < 0.05). However, intergroup comparison of PI showed nonsignificant results (P > 0.05). Anaerobic culture of plaque samples of test group also revealed a significant reduction of microorganisms in comparison with control group. Conclusion: ICG-mediated photothermal therapy can act as an alternative to antimicrobial PDT as an adjunct to SRP in the treatment of chronic periodontitis.
Persistent sex disparities in implantable cardioverter‐defibrillator therapy

Clinical guidelines recommend cardioverter defibrillator implantation for patients with heart failure and reduced ejection fraction. Despite this, women and minorities have been less likely to receive implantable cardioverter‐defibrillator (ICD) therapy than white men. We examined race and sex differences in ICD implantation in a recent cohort.
Malnutrition and Associated Disorders in Tuberculosis and Its Therapy

ABSTRACT Tuberculosis (TB) has become the most important infectious disease to see resurgence worldwide. In 2014, there were 9.6 million documented cases worldwide with a mortality of almost 1.5 million (Global Tuberculosis Report 2014). One of the Millennium Development Goals set by the United Nations was the reversal of the TB epidemic, which has been achieved worldwide with an 18% lower incidence of TB globally compared to the incidence in the year 2000. Though efficient intervention has brought down the relative incidence and mortality of TB globally, the fact remains that one third of the world population has latent TB infection, and 10% of people with latent TB infection develop active TB at some point in their life (The Facts about Tuberculosis 1995). Risk factors that prompt the reactivation of latent TB into active TB are a compromised immune system, HIV, malnutrition, and use of tobacco. In developing and underdeveloped economies, malnutrition and undernutrition play a major role in subverting the immune system and reactivating the latent TB infection. Undernutrition is one of the major factors in India and Southeast Asia leading to an increase in TB infections. Once tuberculosis sets in, it leads to an increase in metabolism and a decrease in appetite that compounds the already present malnutrition. Drawing on previous studies, we have aimed at understanding the relationship between malnutrition and TB infection and making minimal recommendations for corrective action.
Anisotropic Clustering of the SDSS LRG as a Dual Probe of Growth of Structure and Cosmic Expansion

Akira Oka1, Takahiro Nishimichi2, Shun Saito3, Kazuhiro Yamamoto4, Atsushi Taruya3,5,6 1 Department of Physics, University of Tokyo, Tokyo 113-0033, Japan 2 Institute d’Astrophysics de Paris, CNRS, 98 bis Boulevard Arago, F-75014 Paris, France 3 Kavli Institute for the Physics and Mathematics of the Universe, University of Tokyo, Kashiwa, Chiba 277-8583, Japan 4 Department of Physical Science, Hiroshima University, Higashi-Hiroshima 739-8526,Japan 5 Research Center for the Early Universe, School of Science, University of Tokyo, Tokyo 113-0033, Japan 6 Yukawa Institute for Theoreteical Physics, Kyoto University, Kyoto 606-8502, Japan
Designing for mobile experience beyond the native ad click: Exploring landing page presentation style and media usage

Many free mobile applications are supported by advertising. Ads can greatly affect user perceptions and behavior. In mobile apps, ads often follow a “native” format: they are designed to conform in both format and style to the actual content and context of the application. Clicking on the ad leads users to a second destination, outside of the hosting app, where the unified experience provided by native ads within the app is not necessarily reflected by the landing page the user arrives at. Little is known about whether and how this type of mobile ads is impacting user experience. In this paper, we use both quantitative and qualitative methods to study the impact of two design decisions for the landing page of a native ad on the user experience: (i) native ad style (following the style of the application) versus a non‐native ad style; and (ii) pages with multimedia versus static pages. We found considerable variability in terms of user experience with mobile ad landing pages when varying presentation style and multimedia usage, especially interaction between presence of video and ad style (native or non‐native). We also discuss insights and recommendations for improving the user experience with mobile native ads.
Changes in autonomic regulation due to Kangaroo care remain unaffected by using a swaddling device

To investigate the effects of a swaddling device known as the Hugsy (Hugsy, Eindhoven, the Netherlands) towards improving autonomic regulation. This device can be used both in the incubator and during Kangaroo care to absorb parental scent and warmth. After Kangaroo care, these stimuli can continue to be experienced by infants, while in the incubator. Additionally, a pre‐recorded heartbeat sound can be played.
Identification of Rpl29 as a major substrate of the lysine methyltransferase Set7/9

Set7/9 (also known as Set7, Set9, Setd7, and Kmt7) is a lysine methyltransferase that catalyzes the methylation of multiple substrates, including histone H3 and non-histone proteins. Although not essential for normal development and physiology, Set7/9-mediated methylation events play important roles in regulating cellular pathways involved in various human diseases, making Set7/9 a promising therapeutic target. Multiple Set7/9 inhibitors have been developed, which exhibit varying degrees of potency and selectivity in vitro. However, validation of these compounds in vivo has been hampered by the lack of a reliable cellular biomarker for Set7/9 activity. Here, we report the identification of Rpl29, a ribosomal protein abundantly expressed in all cell types, as a major substrate of Set7/9. We show that Rpl29 lysine 5 (Rpl29K5) is methylated exclusively by Set7/9 and can be demethylated by Lsd1 (also known as Kdm1a). Rpl29 is not a core component of the ribosome translational machinery and plays a regulatory role in translation efficiency. Our results indicate that Rpl29 methylation has no effect on global protein synthesis but affects Rpl29 subcellular localization. Using an Rpl29 methylation-specific antibody, we demonstrate that Rpl29K5 methylation is present ubiquitously and validate that (R)-PFI-2, a Set7/9 inhibitor, efficiently reduces Rpl29K5 methylation in cell lines. Thus, Rpl29 methylation can serve as a specific cellular biomarker for measuring Set7/9 activity.
Deception and Shopping Behavior Among Current Cigarette Smokers: A Web-Based, Randomized Virtual Shopping Experiment

Background Virtual stores can be used to identify influences on consumer shopping behavior. Deception is one technique that may be used to attempt to increase the realism of virtual stores. Objective The objective of the experiment was to test whether the purchasing behavior of participants in a virtual shopping task varied based on whether they were told that they would receive the products they selected in a virtual convenience store (a form of deception) or not. Methods We recruited a US national sample of 402 adult current smokers by email from an online panel of survey participants. They completed a fully automated randomized virtual shopping experiment with a US $15 or US $20 budget in a Web-based virtual convenience store. We told a random half of participants that they would receive the products they chose in the virtual store or the cash equivalent (intervention condition), and the other random half simply to conduct a shopping task (control condition). We tested for differences in demographics, tobacco use behaviors, and in-store purchases (outcome variable, assessed by questionnaire) by experimental condition. Results The characteristics of the participants (398/402, 99.0% with complete data) were comparable across conditions except that the intervention group contained slightly more female participants (103/197, 52.3%) than the control group (84/201, 41.8%; P=.04). We did not find any other significant differences in any other demographic variables or tobacco use, or in virtual store shopping behaviors, including purchasing any tobacco (P=.44); purchasing cigarettes (P=.16), e-cigarettes (P=.54), cigars (P=.98), or smokeless tobacco (P=.72); amount spent overall (P=.63) or on tobacco (P=.66); percentage of budget spent overall (P=.84) or on tobacco (P=.74); number of total items (P=.64) and tobacco items purchased (P=.54); or total time spent in the store (P=.07). Conclusions We found that telling participants that they will receive the products they select in a virtual store did not influence their purchases. This finding suggests that deception may not affect consumer behavior and, as a result, may not be necessary in virtual shopping experiments.
Acceleration of Intruding Anterior Tooth by Alveolar Corticotomy

True intrusion is one of the difficult and complex goals to achieve which requires clinical judgment, skills, and experience. Intrusion requires less force level than other tooth movement, but it requires delicacy since the entire stress is concentrated in the apex of the root. Although true intrusion alone is not challenging, eliminating the adverse effect while intruding requires tedious skills of the clinician. A 17-year-old male patient with Class I malocclusion with open bite has a prominent maxillary cortical bone. He had a convex profile with an unpleasant smile. To reduce the bulkiness of cortical bone and to intrude the upper anterior, so the decision was made to perform corticotomy.
Targeting Micrometastases: The Effect of Heterogeneous Radionuclide Distribution on Tumor Control Probability

The spatial distribution of radiopharmaceuticals that emit short-range high linear-energy-transfer electrons greatly affects absorbed dose and biological effectiveness. The purpose of this study was to investigate the effect of heterogeneous radionuclide distribution on tumor control probability (TCP) in a micrometastasis model. Methods: The cancer cell lines MDA-MB-468, SQ20B, and 231-H2N were grown as spheroids to represent micrometastases. The intracellular distribution of a representative radiopeptide (111In-labeled epidermal growth factor) and radioimmunotherapeutic (111In-labeled trastuzumab) was determined in cell internalization experiments. The intratumoral distribution was evaluated by microautoradiography of spheroids. γH2AX staining was performed on spheroid sections to correlate DNA damage with radionuclide distribution. Experimental surviving fractions were obtained using clonogenic assays. A random close-packed algorithm, which models the random packing behavior of cells and reflects variation in the radii of cells and nuclei, was used to simulate 3-dimensional spheroids. Calculated survival fractions were generated using an iterative modeling method based on Monte Carlo–determined absorbed dose with the PENELOPE code and were compared with experimental surviving fraction. Radiobiologic parameters deduced from experimental results and Monte Carlo simulations were used to predict the TCP for a 3-dimensional spheroid model. Results: Calculated survival fractions agreed well with experimental data, particularly when an increased value for relative biological effectiveness was applied to self-dose deposited by sources located in the nucleus and when radiobiologic parameters were adjusted to account for dose protraction. Only in MDA-MB-468 spheroids treated with 111In-epidermal growth factor was a TCP of more than 0.5 achieved, indicating that for this cell type the radiopeptide would be curative when targeting micrometastases. This ability is attributed to the relative radiosensitivity of MDA-MB-468 cells, high nuclear uptake of the radiopeptide, and uniform distribution of radioactivity throughout the spheroid. Conclusion: It is imperative to include biologic endpoints when evaluating the distribution of radionuclides in models emulating micrometastatic disease. The spatial distribution of radioactivity is a clear determinant of biological effect and TCP as demonstrated in this study.
CADAQUES: Metodika pro komplexní řízení kvality dat a informací

The present time is characterized by an ever-increasing amount of acquired and processed data. The aim of this article is to highlight the diversity of currently used data sources, to show their specifics in terms of quality control and introduce own methodology that allows data and information quality management across these sources. The main component of this methodology is a set of basic principles and actions that can be universally applied. One of the key recommendations of this methodology is to focus on a relatively small set of data characteristics, which is relatively easy to manage. Part of the methodology is also a Data Source Maturity Model which could be used to assess the risk associated with the use of a particular data source.