Miracle-dz/UniFAR-FTUs huggingface dataset:
DLIRS: Deep Learning based Intelligent Routing in Software Defined IoT

Software Defined Network (SDN) is a next generation networking model which simplifies the traditional network complexities and improve the utilization of constrained resources. Currently, most of the SDN based Internet of Things(IoT) environments use traditional network routing strategies which work on the basis of max or min metric values. However, IoT network’s heterogeneity, dynamic traffic flow and complexity demands intelligent and self-adaptive routing algorithms because, traditional routing algorithms lack the self-adaptions, intelligence, and efficient utilization of resources. Though SDN has managed the IoT heterogeneity and complexity to some extent, owing to its centralized control and flexibility, still it lacks intelligence. To address this challenge, we proposed a model called Deep Learning based Intelligent Routing Strategy (DLIRS) which uses Deep Learning algorithm to perform routing in SDIoT intelligently and efficiently. Our model uses real-time traffic for training and learning. Results demonstrate that proposed model has achieved high accuracy and low packet loss rate during path selection. Moreover, it has outperformed benchmark routing algorithm (OSPF) and provided encouraging results during high dynamic traffic flow.
Tumor-Specific Cell Death Induction by Noxa Overexpression for Head and Neck Squamous Cell Carcinoma (HNSCC) Treatment

TUMOR-SPECIFIC CELL DEATH INDUCTION BY NOXA OVEREXPRESSION FOR HEAD AND NECK SQUAMOUS CELL CARCINOMA (HNSCC) TREATMENT By: Nicolas Tanner Maxim, B.S. A thesis submitted in partial fulfillment of the requirements for the degree of Masters of Science at Virginia Commonwealth University. Virginia Commonwealth University, 2016 Major Director: Dr. Hisashi Harada, Ph. D VCU School of Dentistry Philips Institute for Oral Health Research The primary focus of this research is the mechanisms of cell death in head and neck squamous cell carcinoma (HNSCC) treatment. These cancers typically originate in squamous cells that line the moist mucosal surfaces of head and neck. HNSCC is commonly treated with a platinum based agent, cisplatin. While the drug does offer strong antitumor effects, its prolonged use often results in tumor-acquired resistance, which limits treatment effectiveness. We have shown that cisplatin treatment induces the expression of a pro-apoptotic BCL-2 family member Noxa, which then initiates caspasedependent apoptosis through its binding and sequestration of pro-survival protein MCL-1 for its inactivation. Without Noxa induction, cell death is significantly reduced when x treating HNSCCs with cisplatin. The objectives of this study are (1) to determine the molecular mechanisms by which Noxa induces cell death in HNSCC cells; (2) to determine the molecular mechanisms of cisplatin-resistance in isogenic HNSCC cell lines. We observed an increase of apoptosis by ectopic expression of Noxa in all HNSCC cell lines tested, but not in immortalized human normal oral keratinocytes (NOK), suggesting that Noxa overexpression is sufficient to induce tumor-specific cell death. Noxa-induced cell death was mediated by BAX and BAK activation. BAK activation was mediated through Noxa binding to MCL-1, but not BCL-XL. Cisplatinresistant cells induced less Noxa and apoptosis, supporting that Noxa induction is prerequisite for apoptosis induced by cisplatin. Taken together, Noxa induces tumorspecific cell death in HNSCC cells primarily through BAX and BAK activation, which suggests the therapeutic potential of this protein.
Improving teachers’ classroom assessment practices

This chapter provides recommendations for improving the use of classroom assessment in Turkey so that it contributes more effectively to supporting student learning. At present, while teachers in Turkey regularly undertake assessments in the classroom, these tend to be dominated by short‑answer, closed‑question formats, like multiple‑choice questions. This limits the range of students’ knowledge and skills that teachers can assess. The focus on summative assessments that result in a numeric mark also limits space for formative assessment, one of the most important types of assessment for learning. This chapter provides suggestions on how teachers can be encouraged to use a broader range of assessment formats and integrate more formative assessment practices into their regular classroom teaching.
Comparative study of cough variant asthma responsive and unresponsive to bronchodilator treatment

Objectives To compare the differences in clinical manifestations,airway inflammation and airway inflammatory mediators between CVA responsive and unresponsive to bronchodilator therapy.Methods Seventy-two patients with CVA were divided into two subgroups according to their different responses to the treatment of bronchodilators,CVA responsive group(55 cases) and unresponsive group(17 cases). Control groups included 26 classic asthmatic patients and 26 healthy volunteers respectively.Differences in clinical manifestation,cough reflex sensitivity to inhaled capsaicin,lung function parameters,airway hyperresponsiveness,total cell number or differentials in induced sputum,and levels of histamine,prostaglandin D2,interleukin-5 and eosinophil cationic protein in supernatants of induced sputum were compared among all the groups.Results CVA responsive to bronchodilator therapy accounted for 76% and unresponsive accounted for 24%. Cough threshold logC5 was lower in the former than that in the latter(P0.05). Lung function parameters such as FEV1,FVC,FEV1/FVC,MMEF and PD20FEV1 tended to be decrease in CVA responsive to bronchodilator therapy when compared with the unresponders,even though the difference was not significant.CVA responsive to bronchodilator therapy presented with a higher percentage of eosinophils in induced sputum(P0.05),higher levels of prostaglandin D2(P0.01) and eosinophil cationic protein(P0.01) in the supernatant of induced sputum than the unresponders did.Moreover,there was an apparent positive correlation between changes in cough symptom score and the percentage of eosinophils(r=0.254,P=0.036) in induced sputum,prostaglandin D2(r=0.422,P=0.007),histamine(r=0.365,P=0.020) or eosinophil cationic protein(r=0.371,P=0.020) in the supernatant of induced sputum after one week treatment with bronchodilators in the responders.A negative correlation was also found between changes in cough symptom score and cough threshold logC5 in these patients(r=-2.064,P=0.025). Conclusion CVA may be divided into two subgroups according to the response to bronchodilator therapy,which possibly has different underlying mechanisms for cough.The varied bronchoconstriction caused by inflammatory mediators in airway may be crucial in determining the efficacy of bronchodilator therapy.
Safety Skills for Clinicians: An Essential Component of Patient Safety

Abstract Health care is on an exciting and evolutionary journey to improve safety and quality in patient care, service provision, and clinical excellence. Systems and processes have been the primary focus of much work on safety and quality, an important reaction to the crude blaming of individuals for safety problems. However, this has led to neglect of the role individuals, both staff and patients', play in maintaining safety and quality. In this paper, we attempt to articulate the concept of safety skills and consider whether it has in relevance to the training of health care professionals. We do this by first making the case for the utility of the concept. We then briefly review concepts of human error and accident causation and turn the analysis round from its usual perspective to consider what skills are needed to anticipate error and prevent harm. These are, for us, the core components of safety skills. These skills are of course already possessed by expert clinicians and others living or working in hazardous domains. However, although they are eventually acquired, they are seldom explicitly articulated and taught in health care. We then briefly review some parallel training courses in hazardous occupations and consider what form safety skills training might take in health care.
The association of smoking with drinking pattern may provide opportunities to reduce smoking among students

There is evidence that smoking and alcohol consumption are paired behaviours among university students, but we know little about how New Zealand students engage in these behaviours. We estimated prevalence of daily and occasional smoking among university students, and associations of smoking with drinking patterns, demographics and smokefree policies of the university. This research was conducted with 2822 university students, aged 17–25, from five New Zealand universities who participated in an online health survey in 2013. Fourteen percent reported they currently smoke occasionally, and 3% reported smoking on a daily basis. Increasing age, living situation, drinking more often, and drinking more alcohol during drinking occasions were all associated with greater levels of smoking. Understanding patterns of smoking in relation to alcohol consumption may help efforts to further reduce smoking prevalence. Specifically, policy makers should consider approaches that de-couple tobacco and alcohol consumption, such as expanding the smokefree perimeter of bars and disallowing the sale of tobacco at premises licensed to sell alcohol.
Is SMART the new stupid? Health worker perspectives on producing PBF indicators

PBF program designers have traditionally selected and priced service delivery indicators based on public health value, and whether the indicator is SMART (specific, measurable, achievable, relevant, and timely). This approach ignores the providers perspective on the value of inputs and opportunity costs of service provision. We conducted in-depth interviews, focus group discussions, and rank order exercises with health workers to elucidate factors that drive their motivation to deliver PBF incentivized services. Health workers identified three key considerations that drive service prioritization: effort to acquire a patient, effort to treat a patient, and health worker locus of control. Health workers consider multiple factors when prioritizing PBF services to maximize their total reward. In pricing PBF services, program designers must understand inputs’ value and total opportunity costs, rather than relying on public health value and the SMART indicator framework alone. When pricing services, PBF program designers should collaborate with health workers to account for the range of factors that health workers consider when alone. When pricing services, PBF program designers should collaborate with health workers to account for the range of factors that health workers consider when making service provision decisions.
Laparoscopic Hepatectomy Compared with Conventional Open Hepatectomy for Hepatocellular Carcinoma:A Systematic Review

Objective To evaluate the efficiency and safety of laparoscopic hepatectomy (LH) and conventional open hepatectomy (OH) in patients with hepatocellular carcinoma (HCC). Methods We searched The Cochrane Library,MEDLINE (1966～2008.3),EMBASE (1966～2008.3),CBM (1979～2008.3),we also handsearched some Chinese journals.Using a defined search strategy,randomized controlled trails and controlled clinical trials of comparing OH with LH for hepatocellular carcinoma were identified.Data were extracted and evaluated by two reviewers independently.The quality of the included trails was evaluated by Deeks JJ's evaluation criterion.Meta-analysis was done using the Cochrane collaboration's Revman 4.2. 10.Results Seven controlled clinical trials (309 patients) were included,The meta-analysis showed that:(1) Four studies (n=198) reported mortality,the mortality rate of the LH group was not significantly different from that of the OH group [OR=1.14,95%Cl (0.15,8.65),P=0.90];(2) Two studies (n=91) reported blood transfusion.There were no significant differences between the two treatment groups in terms of the blood transfusion [OR=0.20,95%Cl (0.03,1.19),P=0.08];(3) Four studies (n=165) reported operation time.There were significant differences in operating time between the two groups [SMD=1.05,95%CI (0.72,1.38),P0.000 01];(4) Four studies (n=165) reported intraoperative blood loss.There were significant differences in intraoperative blood loss between the two groups [SMD=-1.56,95%Cl (-2.39,-0.73),P=0.000 2];(5) Five studies (n=210) reported the duration of hospital stay.There were significant differences in duration of hospital stay between the two groups [WMD=-3.89,95%CI (-5.54,-2.23),P0.000 01];(6) Two studies (n=248) reported complications.There were significant differences in complications between the two groups [OR=0.31,95%Cl (0.13,0.72),P=0.006];(7) Two studies (n=97) reported ALT.There were significant differences in ALT between the two groups [SMD=-1.54,95%Cl (-207,-1.01),P0.000 01]. Conclusion LH is associated with less postoperative complications,operative blood loss,duration of hospital stay and lower ALT,but longer operation time.However,the trails available for this systematic review are limited,so a prospective randomized controlled trial is warranted to fully investigate these and other outcome measures.
Relationship Between the Levels of Normal Conus Medullaris and Body Mass Index in the Turkish Adult Population

Objectives:To establish the normal range of the conus medullaris (CM) in large Turkish adult population and to correlate this position with body mass index and sex. Methods:T2-weighted midline, sagittal and axial spin echo magnetic resonance imaging studies of 1236 patients were assessed to identify the tip of the CM. The CM termination was located in relation to spinal levels and assigned numerical values ranging from 0 to 13. The positions were stratified according to sex and body mass index. Results:The final study group consisted of 443 men and 756 women with a mean age 48 years (range, 16 to 85 y). Patients with spinal deformity were excluded. The caudal level of the CM varied from upper of T12 to the upper-third of L3 with an average of the middle-third of L1. There was no significant difference between sexes, body mass index, and ending levels of CM. Conclusions:The normal CM level in Turkish adult population ranged between the middle-third of T12 and the upper-third of L3. The levels of CM were not associated with BMI and sex. These results also should be taken into account for the management of patients with low-lying CM.
Minimally Invasive Cardiac Valve Surgery: Report of 134 Cases

Objective To summarize the clinical experience of cardiac valve surgery with minimally invasive procedure. Methods Cardiac valve surgery with less invasive techniques were performed in 134 cases. Five aortic valve operations and 2 mitral valve operations were performed through para-sternotomy. Forty-six mitral valve operations and 15 tricuspid valve operations were performed through right anterolateral thoracotomy. Eleven aortic valve operations were performed through limited reversed Z sternotomy. Fifty-five mitral valve operations were performed through limited lower sternotomy. Results Three cases died postoperatively, the mortality was 2.2%, 2 patients died of low cardiac output syndrome, and one died of acute hepatic and renal failure. One hundred and fourteen patients were followed-up from 2 months to 7 years. The follow-up results were excellently. The scar of minimally invasive valve surgery was limited. Conclusion Minimally invasive valve surgery can accelerate recovery, while maintaining overall surgical efficacy. The advantages include a better cosmetic scar, less surgical trauma, minimal respiratory discomfort and a potentially lower risk of infection. It is extremely effective and has become our current technique of choice in every mitral and aortic valve patient.
Ultra Low-Power Rail-to-Rail Voltage Comparator in 65 nm CMOS Technology

The paper addresses a re-design and parameter analysis of a current-mode rail-to-rail voltage comparator with power consumption in nano-watt range across all PVT corners. The comparator design was done in general-purpose 65 nm CMOS technology with the nominal power supply voltage of 1.2 V. The circuit design needs to function properly in industrial temperature range, which is from -20°C to 85°C. The rail-to-rail input voltage range is achieved without employing two differential pairs and also without an internal voltage biasing circuitry. Furthermore, the design process can be easily automated by means of calculation spreadsheet and employing $g_{m}/I_{D}$ design methodology. The presented comparator has been analyzed for robustness and accuracy across all PVT corners using post-layout extracted netlist. A number of parameters was investigated by Monte-Carlo analysis. The power consumption does not exceed $\mathbf{1}\ \mu \mathbf{W}$ in the worst-case scenario, however in typical conditions, it remains below the first third of nano-watt range. The circuit also contains enable signal to minimize the power consumption when the circuit's function is not required. The topology itself, exhibits a promising potential for further research, since it can also work in ultra low-voltage regime thanks to only two stacked transistors.
Clinical Efficacy of Severe Traumatic Brain Injury Treated by Naloxone and Meclofenoxate

Objective Of naloxone Meclofenoxate joint treatment of severe traumatic brain injury clinical effects.Methods 200 patients with severe head injury were randomly divided into 4 groups,Ⅰ group were treated with conventional therapy,Ⅱ in the Ⅰ group of patients based on the use of naloxone treatment,Ⅲ patients in the Ⅰ group of patients based on the use meclofenoxate treatment,Ⅳ patients in the I group of patients,based on the joint use of naloxone and meclofenoxate treatment.4 groups were observed effect and prognosis.Result Group Ⅳ patients with Ⅰ,Ⅱ group,Ⅲ group compared with patients,better patient outcomes and prognosis,the statistical analysis,P0.05,the difference was statistically significant. Ⅱ group and Ⅲ group compared with patients not significantly different,P 0.05,the difference was not statistically significant.Conclusion Naloxone treatment of joint meclofenoxate good effect in severe brain injury,it is worth promoting in clinical use.
Machine learning in men’s professional football: Current applications and future directions for improving attacking play

It is common practice amongst coaches and analysts to search for key performance indicators related to attacking play in football. Match analysis in professional football has predominately utilised notational analysis, a statistical summary of events based on video footage, to study the sport and prepare teams for competition. Recent increases in technology have facilitated the dynamic analysis of more complex process variables, giving practitioners the potential to quickly evaluate a match with consideration to contextual parameters. One field of research, known as machine learning, is a form of artificial intelligence that uses algorithms to detect meaningful patterns based on positional data. Machine learning is a relatively new concept in football, and little is known about its usefulness in identifying performance metrics that determine match outcome. Few studies and no reviews have focused on the use of machine learning to improve tactical knowledge and performance, instead focusing on the models used, or as a prediction method. Accordingly, this article provides a critical appraisal of the application of machine learning in football related to attacking play, discussing current challenges and future directions that may provide deeper insight to practitioners.
The Effects of Timbre on Neural Responses to Musical Emotion

Timbre is an important factor that affects the perception of emotion in music. To date, little is known about the effects of timbre on neural responses to musical emotion. To address this issue, we used ERPs to investigate whether there are different neural responses to musical emotion when the same melodies are presented in different timbres. With a cross-modal affective priming paradigm, target faces were primed by affectively congruent or incongruent melodies without lyrics presented in the violin, flute, and voice. Results showed a larger P3 and a larger left anterior distributed LPC in response to affectively incongruent versus congruent trials in the voice version. For the flute version, however, only the LPC effect was found, which was distributed over centro-parietal electrodes. Unlike the voice and flute versions, an N400 effect was observed in the violin version. These findings revealed different patterns of neural responses to musical emotion when the same melodies were presented in different timbres, and provide evidence for the hypothesis that there are specialized neural responses to the human voice.
EFFECTIVENESS OF MINDFULNESS BASED COGNITIVE THERAPY ON QUALITY OF LIFE, LIFE SATISFACTION AND DEPRESSION OF PATIENTS WITH HIV/AID

Background of the study: Mindfulness based cognitive therapy (MBCT) is a psychological therapy designed to aid in preventing the relapse of depression, specically in individuals with Major Depressive disorder. It uses traditional Cognitive behavioural therapy (CBT) methods and adds in newer psychological strategies such as mindfulness and mindfulness meditation. MBCT helps in promoting successful aging in people with HIV. The total number of people living with HIV in India is estimated at 2.4 million with uncertainty bounds of 1.93 to 3.04 million in 2009. People who are infected with HIV are faced with a profound sense of loss of many levels. It can lead to depression and has a profound effect on the quality of life and life satisfaction. This study was conducted at the outpatient clinic for HIV at Anti-Retroviral center (ART) of Material and Method: Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University. 50 HIV/AIDS diagnosed patients aged 18-60 years were taken for the study between, January 2016 to June 2016.MBCT was offered as a group therapy to patients as an addition to the basic treatment. Result and Discussion: In this study 25 patients were selected for MBCT. It was found that patients who received MBCT an addition to pharmacotherapy showed signicant improvement in QOL, life satisfaction and level of depression as compared to those who only receive pharmacotherapy.