Miracle-dz/UniFAR-FTUs huggingface dataset:
modeling : the 2007 Mw 6 . 6 Chuetsu-Oki , Japan , earthquake

We study the ground motion simulations based on three finite-source models for the 2007 Mw6.6 Niigata Chuetsu-oki, Japan, earthquake in order to discuss the performance of the input ground motion estimations for the near-field seismic hazard analysis. The three models include a kinematic source inverted from the regional accelerations, a dynamic source on a planar fault with three asperities inferred from the verynear-field ground motion particle motions, and another dynamic source model with conjugate fault segments. The ground motions are calculated for an available 3D geological model using a finite-difference method. For the comparison, we apply a goodness-of-fit score to the ground motion parameters at different stations, including the nearest one that is almost directly above the ruptured fault segments. The dynamic rupture models show good performance. We find that seismologically inferred earthquake asperities on a single fault plane can be expressed with two conjugate segments. The rupture transfer from one segment to another can generate a significant radiation; this could be interpreted as an asperity projected onto a single fault plane. This example illustrates the importance of the fault geometry that has to be taken into account when estimating the very-near-field ground motion.
Relational Financing and Innovation in Emerging and Frontier Economies

While the issue of lack of insufficient access to financial resources for performance-enhancing innovative activity may be exacerbated for firms in less well-developed financial markets, relatively little is known about how external financing impacts innovation outside of industrialized environments. To fill this gap, we develop and test a theory explaining the relationship between external finance and innovation based on variation in financial market development, focusing on the capacity for relationship-based financing from family and private equity to alleviate financial constraints to innovation. Examining a large set of emerging market firms, we find that the impact of external financing on innovation depends on the financial market development and that relationship-based finance is an important driver of innovation, especially for smaller and less formally organized firms.
Wear Progression and its Effect on Energy Consumption in Turning of Titanium Alloy ( Ti-6 Al-4 V )

To achieve greater productivity, titanium alloy requires cutting at higher speeds (above 100 m min−1) that affects the tool life and energy consumption during the machining process. This research work correlates the wear progression and Specific Cutting Energy (SCE) in turning Ti-6Al-4V alloy using H13 tools (uncoated carbide) in dry conditions from low to high cutting speeds. Cutting condition employed in this study were selected from published wear map developed for titanium (Ti-6Al-4V alloy) with the same tool. Flank wear growth of the tool has been investigated at different length of cuts in correlation with the SCE under different cutting conditions. The useful tool life was found to be shorter at high-speed machining conditions, thus the end of useful tool life criteria (ISO 3685) was reached at a much shorter length of cuts as compared to low-speed machining conditions. The cutting conditions corresponding to high wear rate also resulted in high SCE. Finally, SCE and wear have been related by a linear relationship that can be used to monitor wear and/or SCE utilization during machining. The results help in the selection of appropriate cutting conditions that will enhance the tool life and minimize SCE consumption during machining titanium alloy.
Usability User Interface dan User Experience Media Pembelajaran

The difficulty of an application used can be overcome by evaluating its usability, accessibility, and effectiveness. This study aims to perform usability testing of the application of Dokok BengkalaBased Android Dictionary Learning Media. The application developed with Unity3D contains the Bengkala kolok language sign language vocabulary exhibited by a 3D object. Task performance is measured using Post-Task Study testing with Single Ease Question (SEQ) method. Usability performance was measured using post-test study using System Usability Scale (SUS) method. The test results show that the designs created have a high acceptability level.
Learning to Share: simultaneous parameter tying and Sparsification in Deep Learning

• Motivation: DNNs usually require expensive storage and computation. • Goal: compress DNNs by (i) simultaneously eliminating unimportant neurons; (ii) tying together weights that correspond to strongly correlated neurons. • Outcome: by automatically tying together weights corresponding to highly correlated features, we alleviate the negative effect of strong correlations that may be induced by noisy inputs or co-adaption.
B R The role of thyroid hormone calorigenesis in the redox regulation of gene expression

Thyroid hormone (TH; 3,3,,5-triiodothyronine, T3) is required for the normal function of most tissues, with major effects on O2 consumption and metabolic rate. These are due to transcriptional activation of respiratory genes through the interaction of T3-liganded TH receptors with TH response elements or the activation of intermediate factors, with the consequent higher production of reactive O2 species (ROS) and antioxidant depletion. T3-induced oxidative stress in the liver triggers the redox upregulation of the expression of cytokines (tumor necrosis factor-α [TNF-α], interleukin-10), enzymes (inducible nitric oxide synthase, manganese superoxide dismutase), and anti-apoptotic proteins (Bcl-2), via a cascade initiated by TNF-α produced by Kupffer cells, involving inhibitor of κB phosphorylation and nuclear factor-κB activation. Thus, TH calorigenesis triggers an expression pattern that may represent an adaptive mechanism to re-establish redox homeostasis and promote cell survival under conditions of ROS toxicity secondary to TH-induced oxidative stress. Mechanisms of expression of respiratory and redox-sensitive genes may be functionally integrated, which could be of importance to understand the complexities of TH action and the outcome of thyroid gland dysfunction. Key terms: Thyroid hormone; Calorigenesis; Oxidative stress; Gene expression Corresponding author: Luis A. Videla, Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Casilla 70000, Santiago-7, Chile. Telephone: 56-2-9786256. Fax: 56-2-7372783. E-mail: lvidela@med.uchile. cl INTRODUCTION Thyroid hormones (TH) are required for the normal function of most tissues of the body, playing essential roles in growth, development, differentiation, and metabolism, with major effects on O2 consumption (QO2) and metabolic rate (Videla, 2000). Current available data indicate that TH calorigenesis is achieved by both (i) a short-term nongenomic signaling mechanism mediated by 3,5diiodothyronine and 3,3,,5-triiodothyronine (T3) leading to the allosteric activation of cytochrome-c oxidase (Moreno et al., 2002), and (ii) a long-term pathway upregulating nuclear and mitochondrial gene transcription through T3 signaling (Fig. 1) (Yen, 2001; Weitzel et al., 2001; Lanni et al., 2003). In several target organs such as liver, a higher pro-oxidant activity is developed as result of the functional interdependence established between TH calorigenesis, cellular QO2, and generation of reactive oxygen (ROS) (Fernández et al., 1985; 2003; Fernández & Videla, 1993a) and nitrogen (RNS) species (Fernández et al., 1997). This respiratory component accounts for 16-25% of the net increase in total QO2 (Fernández & Videla, 1993b). T3induced free radical activity decreases the cellular antioxidant defenses, leading to oxidative stress (Fernández & Videla, 1996) in liver and in extrahepatic tissues of experimental animals exhibiting a calorigenic response (Fig. 1), a phenomenon also observed in human hyperthyroidism (Videla, 2000). Recent
Downregulated expression of ARHGAP10 correlates with advanced stage and high Ki-67 index in breast cancer

Background Rho GTPase-activating protein 10 (ARHGAP10), which catalyzes the conversion of active Rho GTPase to the inactive form, is downregulated in some cancers. However, little is known about ARHGAP10 in breast cancer. Methods The transcriptional expression level of ARHGAP10 in breast cancer was analyzed with the data downloaded from The Cancer Genome Atlas (TCGA) and Oncomine, then verified by reverse-transcription quantitative polymerase chain reaction (RT-qPCR) in 30 pairs of breast cancer tissues and the corresponding adjacent normal tissues. ARHGAP10 protein expression was examined by immunohistochemistry (IHC) in 190 breast cancer and 30 corresponding adjacent normal breast tissue samples. The associations between ARHGAP10 expression and clinicopathological characteristics of patients were analyzed, and Kaplan–Meier Plotter was used to assess the relationship between ARHGAP10 and relapse-free survival (RFS). Different expression levels of ARHGAP10 in response to chemotherapy agents were determined by GEO2R online tool. The potential biological functions of ARHGAP10 were analyzed by Gene Set Enrichment Analysis (GSEA) using data downloaded from TCGA. Results ARHGAP10 mRNA and protein expression was lower in breast cancer tissues than in adjacent normal tissues. Low expression of ARHGAP10 was associated with advanced clinical TNM (cTNM) stage (pb = 0.001) and high Ki-67 index (p = 0.015). Low expression of ARHGAP10 indicated worse RFS (p = 0.0015) and a poor response to chemotherapy (p = 0.006). GSEA results showed that ARHGAP10 was involved in signaling pathways including protein export, nucleotide excision repair, base excision repair, focal adhesion, JAK-STAT pathway and the actin cytoskeleton.
Short-term load forecasting using an Artificial Neural Network for Battery Energy Storage System

Load levelling that use recent spotlighted the Battery Energy Storage System (BESS) saves spare electricity or low cost electricity. The saved electricity can be used for peak power demand time. In this paper, load is predicted for purpose of operating the BESS effectively. By analysing pattern of industrial load, it is classified into workdays, Saturday and holidays. Then apply ANN on workdays load pattern from classified load patterns to predict load. To increase accuracy, number of neurons in hidden layer and learning data period are changed for estimation of load. After that, error rate was calculated for comparison and analysis.
Atorvastatin and Conditioned Media from Atorvastatin-Treated Human Hematopoietic Stem/Progenitor-Derived Cells Show Proangiogenic Activity In Vitro but Not In Vivo

Myeloid angiogenic cells (MAC) derive from hematopoietic stem/progenitor cells (HSPCs) that are mobilized from the bone marrow. They home to sites of neovascularization and contribute to angiogenesis by production of paracrine factors. The number and function of proangiogenic cells are impaired in patients with diabetes or cardiovascular diseases. Both conditions can be accompanied by decreased levels of heme oxygenase-1 (HMOX1), cytoprotective, heme-degrading enzyme. Our study is aimed at investigating whether precursors of myeloid angiogenic cells (PACs) treated with known pharmaceuticals would produce media with better proangiogenic activity in vitro and if such media can be used to stimulate blood vessel growth in vivo. We used G-CSF-mobilized CD34+ HSPCs, FACS-sorted from healthy donor peripheral blood mononuclear cells (PBMCs). Sorted cells were predominantly CD133+. CD34+ cells after six days in culture were stimulated with atorvastatin (AT), acetylsalicylic acid (ASA), sulforaphane (SR), resveratrol (RV), or metformin (Met) for 48 h. Conditioned media from such cells were then used to stimulate human aortic endothelial cells (HAoECs) to enhance tube-like structure formation in a Matrigel assay. The only stimulant that enhanced PAC paracrine angiogenic activity was atorvastatin, which also had ability to stabilize endothelial tubes in vitro. On the other hand, the only one that induced heme oxygenase-1 expression was sulforaphane, a known activator of a HMOX1 inducer—NRF2. None of the stimulants changed significantly the levels of 30 cytokines and growth factors tested with the multiplex test. Then, we used atorvastatin-stimulated cells or conditioned media from them in the Matrigel plug in vivo angiogenic assay. Neither AT alone in control media nor conditioned media nor AT-stimulated cells affected numbers of endothelial cells in the plug or plug's vascularization. Concluding, high concentrations of atorvastatin stabilize tubes and enhance the paracrine angiogenic activity of human PAC cells in vitro. However, the effect was not observed in vivo. Therefore, the use of conditioned media from atorvastatin-treated PAC is not a promising therapeutic strategy to enhance angiogenesis.
Dimensionality of Reading Skills With Elementary-School-Age Children

ABSTRACT Confirmatory factor analyses of data from 1,501 kindergarten to 5th-grade children who completed 3 measures of decoding, 3 measures of reading comprehension, and 3 measures of listening comprehension as part of a larger study were used to identify the dimensionality of reading skills across elementary school. A 1-factor (reading) model was the best fitting model for the reading measures for kindergarten through 2nd grade, and a 2-factor (decoding, reading comprehension) model was the best fitting model for 3rd through 5th grade. Structural analyses revealed little evidence that any of the reading-comprehension measures were more or less associated with either listening comprehension or decoding than the other reading-comprehension measures, indicating that each measure assessed the same underlying construct. These results support a developmental pattern for the emergence of decoding and reading comprehension as distinctly measurable constructs, with a distinct reading comprehension construct not emerging until the 3rd grade.
Taxonomic, biological and geographical traits of species in a coastal dune flora in the southeastern Cape Floristic Region: regional and global comparisons

In Mediterranean-Climate Ecosystems (MCEs), Holocene coastal dunes comprise small, fragmented and dynamic features which have nutritionally imbalanced and excessively drained, droughty, sandy soils. These characteristics, along with summer drought and salt-laden winds, pose many challenges for plant colonization and persistence. Consequently, MCE dune floras are likely to be distinctive with a high proportion of habitat specialists and strong convergence in growth form mixes. Very little research has compared the species traits of dune floras within and across MCEs. This paper contributes to filling that gap. Here, we analyze the taxonomic, biological and geographical traits for all 402 species in a flora from a dune landscape (Cape St Francis) in the southeastern Cape Floristic Region (CFR) and compare patterns with the trait profiles of other dune floras at a regional (CFR) and global (MCE) scale. Within the CFR, the southeastern (all-year-rainfall) flora at Cape St Francis had a similar trait profile to western (winter-rainfall) dune floras, except for having a lower representation of species belonging to CFR-endemic clades, and higher number of species associated with tropical lineages. The St Francis flora, in common with other CFR and MCE floras, was dominated by members of the Asteraceae, Fabaceae and Poaceae. Some 40% of the St Francis flora was endemic to the CFR, typical of the high rate of MCE-level endemism elsewhere in the CFR, and in other MCEs. About 30% of the flora was confined to calcareous sand, a value typical for many other MCE sites. The St Francis flora, as well as other CFR dune floras, differs from those of other MCEs by having many species associated with shrubby lineages, and by the relatively high incidence of species associated with tropical lineages. The growth form profile of the St Francis and other CFR floras shows strongest similarity with that of Australian MCE dunes in that in both regions, evergreen hemicryptophytes and shrubs share dominance, and annuals are floristically and ecologically subordinate. The least similar of MCEs to the St Francis trait profile is the Mediterranean Basin where annuals are the most frequent growth form while shrubs are subordinate. California and Chile dune floras appear to occupy an intermediate position, in terms of growth form mix, between the Cape and Australia on the one hand, where dune floras have retained features typical of nutrient-poor soils, and the Mediterranean Basin, where dwarf, deciduous shrubs and annuals dominate the life form spectrum. All MCE dunes are threatened by alien plants, infrastructure development, tourism demands and rising sea levels. The high incidence of species of conservation concern in CFR dune floras underestimates the exponentially increasing threats to their habitats, which are already historically at a much-reduced extent. All remaining coastal dune habitat in the CFR, and probably in other MCEs, should be conserved in their entirety.
The use of biochar in animal feeding

Biochar, that is, carbonized biomass similar to charcoal, has been used in acute medical treatment of animals for many centuries. Since 2010, livestock farmers increasingly use biochar as a regular feed supplement to improve animal health, increase nutrient intake efficiency and thus productivity. As biochar gets enriched with nitrogen-rich organic compounds during the digestion process, the excreted biochar-manure becomes a more valuable organic fertilizer causing lower nutrient losses and greenhouse gas emissions during storage and soil application. Scientists only recently started to investigate the mechanisms of biochar in the different stages of animal digestion and thus most published results on biochar feeding are based so far on empirical studies. This review summarizes the state of knowledge up to the year 2019 by evaluating 112 relevant scientific publications on the topic to derive initial insights, discuss potential mechanisms behind observations and identify important knowledge gaps and future research needs. The literature analysis shows that in most studies and for all investigated farm animal species, positive effects on different parameters such as toxin adsorption, digestion, blood values, feed efficiency, meat quality and/or greenhouse gas emissions could be found when biochar was added to feed. A considerable number of studies provided statistically non-significant results, though tendencies were mostly positive. Rare negative effects were identified in regard to the immobilization of liposoluble feed ingredients (e.g., vitamin E or Carotenoids) which may limit long-term biochar feeding. We found that most of the studies did not systematically investigate biochar properties (which may vastly differ) and dosage, which is a major drawback for generalizing results. Our review demonstrates that the use of biochar as a feed additive has the potential to improve animal health, feed efficiency and livestock housing climate, to reduce nutrient losses and greenhouse gas emissions, and to increase the soil organic matter content and thus soil fertility when eventually applied to soil. In combination with other good practices, co-feeding of biochar may thus have the potential to improve the sustainability of animal husbandry. However, more systematic multi-disciplinary research is definitely needed to arrive at generalizable recommendations.
Diagnostic Sensitivity of Different Reference Bodies When Using Scheimpflug Tomography in a Myopic Population with Keratoconus

Purpose To establish which reference body offers the greatest sensitivity in keratoconus (KC) diagnosis, obtain normative data for the myopic population with toric ellipsoid reference bodies, and determine the cutoff points for a population with KC. Methods A retrospective, observational study of the entire Scheimpflug tomographer database of the Fundación Jiménez Díaz in Madrid was conducted to identify a normal myopic and a KC myopic population. Three different reference bodies were tested on all patients: best fit sphere (BFS), best fit toric ellipsoid with fixed eccentricity (BFTEFE), and best fit toric ellipsoid (BFTE). Anterior and posterior elevation measurements at the apex and thinnest point were recorded, as well as the root mean square of posterior elevations (RMS-P). Normative data were extracted, and receiver operating characteristic (ROC) curves were generated to obtain cutoff points between the normal and KC population. Results A total of 301 eyes were included, comprising 219 normal myopic and 82 myopic KC eyes. BFS and BFTEFE produced the best results when measuring posterior elevation at the thinnest point. BFTE had better sensitivity with the RMS-P. From all measurements, best sensitivity (100%) was achieved with a cutoff point of 8 μm of posterior elevation at the thinnest point using the BFTEFE. BFTE was found to hide the cone in certain patients. Conclusions Posterior elevation measured at the thinnest point with a BFTEFE is the best-performing parameter and, therefore, is recommended to discriminate between normal and KC patients within a myopic population.