Miracle-dz/UniFAR-FTUs huggingface dataset:
Leunca (Solanum nigrum L.) Herbs Ethanolic Extract Increase Cytotoxic Activity of Cisplatin on Hela Cervical Cancer Cells

Cervical cancer is one of leading causes of cancer death in women in the developing countries. The use of cisplatin as chemotherapy agent in cervical cancer is known to cause side effects and also resistance for long-term uses. One of the strategies to prevent cervical cancer based on combination agents is being developed. Leunca (Solanum nigrum L.) has been revealed to inhibit growth of human cancer cells. Therefore, it can be used in combination with cisplatin to reduce those side effects and prevent the occurrence of cell resistance. Ethanolic extract of Leunca Herb (ELH) and cisplatin were tested their cytotoxic effect on HeLa cervical cancer cell by using MTT assay to determine IC50 value. The combinationss of cisplatin-ELH were tested to determine the combination index (CI value). The IC50 of ELH and cisplatin on HeLa cells were 227 µg/mL and 17 µM. rRespectively. Tthe study of combination resulted that almost all the index combinations were <0,9 showed the effect of synergism combination. The Ooptimum concentration of combination was 1/8 IC50 cisplatin–1/8 IC50 ELH. The results indicated that ELH had a potency to be combination agent to enhance the activity of cisplatin on HeLa cervical cancer cells. Therefore, further study on its molecular mechanism needs to be explored. Key words: Leunca (Solanum nigrum L.), cisplatin, cytotoxic, combination agent, HeLa cells
Diploid Male Production of Two Amazonian Melipona Bees (Hymenoptera: Apidae)

The diploid male has already been recorded for Melipona Illger, and herein, in Melipona seminigra merrillae Cockerell and Melipona interrupta manaosensis Schwarz. This paper was carried out at the Instituto Nacional de Pesquisas da Amazonia (INPA), Manaus, AM, Brazil. We produced and monitored 31 new colonies of M. s. merrillae and 32 new colonies of M. i. manaosensis. We sampled 2,995 pupae of M. s. merrillae and 2,020 of M. i. manaosensis. In colonies with a 1 : 1 sex ratio, male diploidy was confirmed by cytogenetic analysis and workers’ behavior. We estimated 16 sex-determining alleles in M. s. merrillae and 22 in M. i. manaosensis. In colonies of M. i. manaosensis in a 1 : 1 sex ratio, workers killed the males and the queen that produced them soon after they emerged, as predicted. This behavior was not registered for M. s. merrillae, and sex ratios did not stay 1 : 1, indicating polyandry for this species.
Investigating the effects of virtual social networks on entrepreneurial marketing

Article history: Received January 20, 2014 Accepted 30 August 2014 Available online September 15 2014 This paper presents an empirical investigation to study the effects of virtual social networks on entrepreneurial marketing. The study designs a questionnaire in Likert scale based on a model originally developed by Morris et al. (2002) [Morris, M. H. , Schindehutte, M. , & LaForge, R. W. (2002). Entrepreneurial marketing: a construct for integrating emerging entrepreneurship and marketing perspectives. Journal of Marketing Theory and Practice, 10(4), 1-19. ]. The study considers the effects of three components of virtual social network (VSN); namely structural VSN, interaction VSN and functional VSN on entrepreneurial marketing. Using structural equation modeling, the study has determined positive and meaningful effects of all three VSN components on entrepreneurial marketing. © 2014 Growing Science Ltd. All rights reserved. Virtual social networks Entrepreneurial marketing Structural Virtual Social Network Interaction Virtual Social Network Functional Virtual Social Network
Induced-Drag Compressibility Correction for Three-Dimensional Vortex-Lattice Methods

CD = drag coefficient CDi = induced-drag coefficient CD0 = zero-lift drag coefficient CL = lift coefficient CL ;c = compressible lift slope, 1= deg CL ;i = incompressible lift slope, 1= deg CP = pressure coefficient CP0 = incompressible pressure coefficient F = force, N k = induced-drag factor L = vortex segment direction vector M = Mach number Veff = effective velocity at vortex core, m=s Vrot = velocity induced by rigid-body rotations, m=s V = velocity induced by vorticity, m=s V c = velocity induced by compressible vorticity, m=s V1 = freestream velocity, m=s w = aerodynamic influence matrix = vortex strength, m=s = aspect ratio
Knowledge Based Specialists the Determinant Driven Force of the Knowledge Based Economy

Fundamental mutation of the last decade is the shaping of a new type of economy as well as a new type of society. The main objectives of our paper are to highlight the emergence of a new social class - knowledge based specialists, and to emphasize the main features, and their impact on economic performance and functionality. From a methodological point of view, the article is based on theoretical and factual analysis of economic and social evolution from last decades. The paper is structured in the following main components: short presentation of the concept of knowledge revolution, identification and analysis of structural changes in the modern economy, highlighting and evaluation of major changes occurring in the types and content of occupations in the knowledge economy, presenting the main features of the new social class and argumentation the determinant role and impact of knowledge based specialists in the knowledge economy and society.
Evaluation of High Levels of Distillers Dried Grains with Solubles (DDGS) in Broiler Diets 1

A trial was conducted to evaluate high levels of distillers dried grains with solubles (DDGS) in broiler diets throughout a 49 d growing period. Diets were formulated based on digestible amino acid content to contain 0, 10, 20, 30, 40, or 50% DDGS. Diets were formulated to be optimum nutrient density commensurate with approximately 1% supplemental poultry oil. Each dietary treatment was assigned to four replicate pens with 25 commercial male broiler chicks. Starter (0-14 d) and grower (14-35 d) diets were fed as pellets with finisher (35-49 d) diets fed as mash. Bulk density (mass/volume) was determined on all the diets. Body weights and feed consumption were determined at 14, 35, 42 and 49 d of age. At the conclusion of the study, five representative birds per pen were processed to determine dressing percentage and parts yield. Generally, the bulk density of pellet or mash diets in all different growth periods decreased as DDGS inclusion rates increased, especially in mash diets. Level of DDGS had little effect on body weight at any age until up to 20% inclusion, after which body weight declined significantly. Feed intake was not significantly affected by level of DDGS during all the periods except of 0-14 d. For the whole period (0-49 d), the estimated metabolizable energy intake by chickens was less as DDGS inclusion increased. Increasing DDGS levels significantly increased calorie conversion ratio (CCR, calorie/gain ratio), especially during the period of 0-42 and 0-49 d. Dressing percentage decreased linearly with increasing DDGS levels from 0-50%. There was a significant reduction in breast meat or leg quarter yield as a percentage of live weight with increasing DDGS inclusion, while birds fed higher levels of DDGS had higher wings as percentage of live weight. These results indicate that up to 30% DDGS could be used in broiler diets if price was justified. Inclusion of high levels of DDGS reduces the bulk density and pellet quality and may be a major reason for reduced performance. Low energy density of DDGS diets is probably the limiting factor in meeting the energy needs of the chick.
Assessing Employee Attitudes towards Organizational Commitment and Change: The Case of King Faisal Hospital in Al-Taif Governorate, Kingdom of Saudi Arabia

This study investigates the attitudes of employees toward organizational commitment and change. It was conducted at King Faisal Hospital in Al-Taif Governorate, KSA. It is the first empirical work in the field of Human Resources Management aiming at analyzing the attitudes of employees toward organizational commitment and change. The study tackles the linkage between employees’ attitudes towards organizational commitment and change which is one of the most significant constructs in organizational behavior. The present study investigates the evaluative attitudes of the employees towards organizational commitment and change. It will also illustrate the relationship between organizational commitment and change. Three groups of employees were examined. Of the 350 questionnaires that were distributed, 295 usable questionnaires were returned, a response rate of 84%. The finding reveals that there are differences among the three groups of employees regarding their evaluative attitudes towards organizational commitment and change. Also, this study showed that there is an association between organizational commitment and change. Organizational commitment is one of the important elements that have impact on organizational change. It plays an important role in employee’s acceptance of change. It will result in willingness to accept organizational change. In sum, employees with high organizational commitment are more willing to exert more effort in a change project. Therefore, it is more likely to develop positive attitudes towards organizational change. Finally, the implications of this study are discussed.
Volumetric mesh parameterization to a canonical template

We present a volumetric mesh-based algorithm for mapping the placenta to a canonical template to enable effective visualization of local anatomy and function. Monitoring placental function in vivo promises to support pregnancy assessment and to improve care outcomes. We aim to alleviate visualization and interpretation challenges presented by the shape of the placenta when it is attached to the curved uterine wall. We flatten a volumetric mesh that captures placental shape to resemble the well-studied ex vivo shape. We formulate our method as finding a piecewise affine map from the in vivo shape to an ellipsoidal or a cylindrical template while minimizing the symmetric Dirichlet energy to control distortion throughout the volume. Local injectivity is enforced via constrained line search during gradient descent. We evaluate the proposed method in the context of a twin pregnancy study that includes MRI scans of seven women. We achieve sub-voxel accuracy in mapping the boundary of the placenta to the template, while successfully controlling distortion. We demonstrate that our approach enhances visualization of the placental anatomy and is generalizable to map to a number of canonical templates. Thesis Supervisor: Polina Golland Professor of Electrical Engineering and Computer Science Thesis Supervisor: Justin Solomon Assistant Professor of Electrical Engineering and Computer Science
Genetic Differentiation of Draa Indigenous Breed and Relationships with Other Goat Populations Assessed by Microsatellite DNA Markers

Moroccan goats are characterized by the presence of different populations identified only based on their phenotypes. The objectives of this study were to assess the genetic differentiation of the Draa goat breed and to analyze its genetic structure and its relationships with other local populations using 12 microsatellite markers. The screening was done in South Eastern and Southern Morocco on 192 animals form 5 populations, including Draa, Atlas, Barcha, Ghazzalia breeds, and from a set of goats showing highly variable phenotypes grouped together into “undefined goats” population. Population structure was assessed by standard diversity indices, multivariate statistics, analysis of molecular variance and bayesian clustering techniques. The mean allelic richness was 6.526, varying from 2.777 to 9.669. More than 88.4% of the total variance was distributed between individuals and only 1.85% was due to differences between populations. The Draa breed had the lowest observed heterozygosity (0.579), the highest inbreeding coefficient (0.161) and a higher number of deviations from Hardy-Weinberg equilibrium. Moreover, it had the highest genetic distances from the other populations. Bayesian clustering showed a high level of admixture between populations, with a single well defined cluster identifiable within Draa breed. It was concluded that the studied Moroccan goat populations have a substantial but weakly structured genetic diversity, with the exception of Draa breed which shows a higher degree of differentiation and population substructure.
Rapid Publication Identification of an Immunodominant Mouse Minor Histocompatibility Antigen ( MiHA ) T Cell Response to a Single Dominant MiHA Causes Graft-versus-Host Disease

T cell responses to non-MHC antigens are targeted to a restricted number of immunodominant minor histocompatibility antigens whose identity remains elusive. Here we report isolation and sequencing of a novel immunodominant minor histocompatibility antigen presented by H-2D b on the surface of C57BL/6 mouse cells. This nonapeptide (AAPDNRETF) shows strong biologic activity in cytotoxic T lymphocyte sensitization assays at concentrations as low as 10 pM. C3H.SW mice primed with AAPDNRETF in incomplete Freund’s adjuvant generated a potent anti-C57BL/6 T cell-mediated cytotoxic activity, and T lymphocytes from AAPDNRETF-primed mice caused graft-versus-host disease when transplanted in irradiated C57BL/6 recipients. These results ( a ) provide molecular characterization of a mouse dominant minor histocompatibility antigen, ( b ) identify this peptide as a potential target of graft-versus-host disease and, ( c ) more importantly, demonstrate that a single dominant minor antigen can cause graft-versus-host disease. These findings open new avenues for the prevention of graft-versus-host disease and should further our understanding of the mechanisms of immunodominance in T cell responses to minor histocompatibility antigens. (J. Clin. Invest. 1996. 98:622–628. )
The Anti-Paradox of Cooperation: Diversity Pays!

This paper considers the stability and success of a pubic good agreement. We allow for any type and degree of asymmetry regarding benefits and costs. We ask the question whether asymmetry and which type and degree of asymmetry is conducive to cooperation? We employ a simple non-cooperative game-theoretic model of coalition formation and derive analytical solutions for two scenarios: an agreement without and with optimal transfers. A central message of the paper is that asymmetry does not have to be an obstacle for successful cooperation but can be an asset. We qualify and reverse two central results in the literature. Firstly, the paradox of cooperation, known since Barrett (1994) and reiterated by many others afterwards, stating that under those conditions when cooperation would matter most, stable agreements achieve only little. Secondly, a kind of "coalition folk theorem", known (without proof) in the literature for a long time, stating that without transfers, stable coalitions will be smaller with asymmetric than symmetric players. We show that even without transfers the grand coalition can be stable if there is a negative covariance between benefit and cost parameters with massive gains from cooperation. Moreover, with transfers, many distributions of benefit and cost parameters lead to a stable grand coalition, again, some of them implying huge gains from cooperation. Stability and success greatly benefit from a very skewed asymmetric distribution of benefit and costs, i.e. diversity pays!
Deposited in DRO : 12 January 2018 Version of attached le : Published Version Peer-review status of attached

Demand side management (DSM) plays an important role in smart grid. In this paper, a hierarchical day-ahead DSM model is proposed, where renewable energy sources (RESs) are integrated. The proposed model consists of three layers: the utility in the upper layer, the demand response (DR) aggregator in the middle layer, and customers in the lower layer. The utility seeks to minimize the operation cost and give part of the revenue to the DR aggregator as a bonus. The DR aggregator acts as an intermediary, receiving bonus from the utility and giving compensation to customers for modifying their energy usage pattern. The aim of the DR aggregator is maximizing its net benefit. Customers desire to maximize their social welfare, i.e., the received compensation minus the dissatisfactory level. To achieve these objectives, a multiobjective problem is formulated. An artificial immune algorithm is used to solve this problem, leading to a Pareto optimal set. Using a selection criterion, a Pareto optimal solution can be selected, which does not favor any particular participant to ensure the overall fairness. Simulation results confirm the feasibility of the proposed method: the utility can reduce the operation cost and the power peak to average ratio; the DR aggregator can make a profit for providing DSM services; and customers can reduce their bill.
RESPONSE SURFACE METHODOLOGY MODEL OF HYDROTHERMAL TREATMENT PARAMETERS ON DECAY RESISTANCE OF OIL PALM WOOD

Wood from matured oil palm (Elaeis guineensis) trunks (OPT) or oil palm wood (OPW) is an ideal alternative material to substitute timber that is now experiencing depletion. As the world second largest producer of palm oil, there are 5.64 million ha of oil palm plantations in Malaysia, which accounts for 17% of the total land area of Malaysia (MPOB 2015). Oil palm trees are being replanted at the end of their economic lifespan, which is 25–30 years, generating an estimation of 7 million metric tons of felled OPT annually (Bakar et al. 2008). As a biomass waste, full utilisation of these felled OPT could be beneficial from environmental and socioeconomical aspects. Nevertheless, OPW is very susceptible to biological deterioration agents such as termites and fungi, despite having better radial and tangential stability than rubberwood. The biological durability of OPW is very low, classified as class 5 or perishable (Bakar et al. 2013). Therefore, treatment is needed to improve its biological durability. Heat treatment RESPONSE SURFACE METHODOLOGY MODEL OF HYDROTHERMAL TREATMENT PARAMETERS ON DECAY RESISTANCE OF OIL PALM WOOD
The impact of cultural dissonance and acculturation orientations on immigrant students' academic performance

Prior research has documented meaningful differences between school performance of immigrant and native students. Multicultural education has been associated with academic failure of foreign students. The aim of this study was to examine the impact of a set of psychosocial variables on the perceived academic achievement of first generation immigrant adolescents from public secondary schools in Northern Spain. Results showed that 46% of the variability in foreign students’ perceived academic performance was explained by home-school cultural dissonance. We also explored the impact of acculturation orientation to separation, perception of discrimination from teachers, school adjustment and psychological well-being in academic performance. Any multicultural education context should take into account psychosocial adjustment, given its influence on academic performance of all students.
Factorizable Representation of Current Algebra : Non commutative extension of the Levy-Kinchin formula and cohomology of a solvable group with values in a Hilbert space

A notion of factorizable representation is defined and all factorizable representations of a commutative group of functions as well as those of the current commutation relations and canonical commutation relations are explicitly given in the continuous tensor product space (i.e. the Fock space). The formula for a state functional of a factorizable representation is a non-commutative extension of the Levy-Kinchin formula in probability theory. In the course of analysis, the most general form of a first order cocycle of any solvable group with values in a Hilbert space is determined. Non trivial cohomologies appear by two entirely different mechanism, namely a topological one on infinite dimensional space and an algebraic one on a finite dimensional space. The immaginary part of an inner product of such cocycle is a second order cocycle. The condition that it is a coboundary is discussed.
Response of Two Pieris (Lepidoptera: Pieridae) Species to Fertilization of a Host Plant

In this study, we explored relationships among plant fertilization, plant phytochemical compositions, and the performance of Pieris butterfly larvae. Cabbages (Brassica oleracea var. capitata L.) were grown under 2 levelsof nutrients, and their foliar chemistry (water, nitrogen, and total glucosinolates) was measured. Two species of cabbage white butterflies, Pieris rapae crucivora and P. canidia canidia, were reared on foliage from each of the 2 treatments to measure insect performance. Oviposition responses of P. rapae crucivora and P. canidia canidia to fertilized vs. unfertilized host plants were compared using choice tests. Foliar water and nitrogen contents increased with increased nutrient availability. Concentrations of total glucosinolates, however, decreased with increased nutrient availability. For the most part, insect performance varied significantly between the 2 nutrient treatments. Both insect species performed well on the fertilized treatments which contained high water and nitrogen, but low glucosinolate contents. Ovipositional female butterflies of both species were also found to prefer fertilized plants. Finally, our results also indicate that P. rapae-crucivora performed relatively better on high-nutrient plants.
Exploring the wicked problem of athlete and consumer vulnerability in sport

Purpose: This paper aims to extend the literature on wicked problems in consumer research by exploring athlete and consumer vulnerability in sport and the potential role that social marketing can play in addressing this problem. Design/methodology/approach: This paper conceptualises the wicked problem of athlete and consumer vulnerability in sport, proposing a multi-theoretical approach to social marketing, incorporating insights from stakeholder theory, systems theory and cocreation to tackle this complex problem. Findings: Sport provides a rich context for exploring a social marketing approach to a wicked problem, as it operates in a complex ecosystem with multiple stakeholders with differing, and sometimes conflicting, objectives. It is proposed that consumers, particularly those that are highly identified fans, are key stakeholders that have both facilitated the problematic nature of the sport system and been rendered vulnerable as a result. Further, a form of consumer vulnerability also extends to athletes as the evolution of the sport system has led them to engage in harmful consumption behaviours. Social marketing, with its strategic and multi-faceted focus on facilitating social good, is an apt approach to tackle behavioural change at multiple levels within the sport system. Practical implications: Sport managers, public health practitioners and policymakers are given insight into the key drivers of a growing wicked problem as well as the potential for social marketing to mitigate harm. Originality/value: This paper is the first to identify and explicate a wicked problem in sport. More generally it extends insight into wicked problems in consumer research by examining a case whereby the consumer is both complicit in, and made vulnerable by, the creation of a wicked problem. This paper is the first to explore the use of social marketing in managing wicked problems in sport.