Miracle-dz/UniFAR-FTUs huggingface dataset:
Curcumin: Nutraceutical and Pharmaceutical Applications

Medicinal plants can be used for the treatment of many diseases is associated to folk medicine from different parts of the world. Natural and herbal products from some plants, fungi, bacteria’s and other organisms, continue to be used in pharmaceutical formulations either as pure compounds or as extracts. There is a great variety of compounds that can be extracted and characterized from plants, herbs and roots. One good example is the harmaline, one of the indole alkaloids found in Peganumharmala (Zygo-phyllaceae), used in the treatment of dermatosis. Extensive scientific research on curcumin, a natural compound present in the rhizomes of plant Curcuma longa Linn. The natural product curcumin (diferuloylmethane, 1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione), obtained from the spice turmeric is a rhizomatous herbaceous plant belonging to the family Zingiberaceae, exhibits numerous biological activities. It is the major constituent of the oleoresin of turmeric. In the crude extract of rhizomes of C. longa about 70-76% curcumin is available along with about 16% demethoxycurcumin and 8% bisdemethoxycurcumin. Curcumin which is commonly used as a spice is also well documented for its medicinal properties in Indian and Chinese systems of medicine. It is extensively used for imparting color and flavor to the food. Extensive scientific research on curcumin had demonstrated a wide spectrum of therapeutic effects such as ant-inflammatory, antibacterial, antiviral, antifungal, antitumor, antispasmodic, hepato-protective, anti-angiogenic, anti-oxidant, wound healing, anti-cancer effects, nematocidal activities, anti-protozoal activity, anti-venom activity. Recently, its potential utility in autoimmune deficiency syndrome (AIDS) had been demonstrated. A number of curcumin based pyrazoles an isoxazoles and a diazepine had been synthesized and evaluated for their antibacterial activities. Keywords: Curcumin, ant-inflammatory, antibacterial, antiviral, antifungal, antitumor, antispasmodic, hepato-protective, anti-angiogenic.
Stent selection for percutaneous coronary intervention

Percutaneous coronary intervention (PCI) with stent deployment is the dominant form of myocardial revascularization, with millions of procedures performed worldwide each year. Stent design has evolved substantially over time and there are now a wide range of options available to the interventional cardiologist. This review will cover the development of intracoronary stents and the patient and vessel factors which are important in stent selection.
Alertas de tiempo severo mediante descargas eléctricas: el algoritmo del Lightning Jump en el Servei Meteorològic de Catalunya

RESUMEN El Servei Meteorològic de Catalunya (SMC) ha desarrollado una versión de la herramienta del Lightning Jump que, basada en datos totales de descargas eléctricas, permite realizar avisos de tiempo severo (granizo de diámetro superior a 2 cm, vientos fuertes asociados a convección, tornados y/o reventones) con una antelación de entre 30 y 120 minutos. Este tiempo de antelación depende de la tipología de la tormenta, pero pretende ser un revulsivo a la hora de poder ayudar a Protección Civil a la hora de mejorar las alertas y , además, gestionar de manera más eficiente los equipos de emer gencia, acotando las zonas a avisar . Después de un periodo inicial de análisis de episodios históricos (2006-2013), se puso en fase preoperativa la herramienta durante la campaña 2016. En la siguiente se analizó la casuística del tiempo real y , n la de 2018, se ha realizado un trabajo de gestión de la herramienta, con la realización de avisos a nivel interno. Las dos últimas campañas han permitido mejorar también la obtención de registros en superficie, hecho que ha facilitado la validación de la herramienta. Este último punto resulta clave a la hora de ayudar al predictor a entender el funcionamiento de la aplicación y cómo debe actuar en situaciones del tiempo real. Está previsto que durante la campaña 2019 ya se realicen avisos a nivel operativo.
Trombólisis endovenosa como tratamiento del ACV isquémico agudo en Colombia: una revisión sistemática de la literatura

resumen INTRODUCCIÓN: en Colombia el ataque cerebrovascular isquémico es la primera causa de discapacidad y la tercera causa de muerte, el uso oportuno de rt-PA puede mejorar su pronóstico. OBJETIVOS: conocer la experiencia de centros acerca del uso de trombolíticos para el ACV en Colombia, a fin de establecer brechas de atención y oportunidades de mejoría. MÉTODOS: se hizo revisión sistemática utilizando Google, Google Académico, PubMed, Scielo, así como otras fuentes de literatura gris para las publicaciones sobre trombólisis en Colombia, con un análisis de la calidad de los estudios, así como un registro de tiempos de atención, escalas utilizadas y medidas de desenlace. RESULTADOS: al final se obtuvieron seis estudios, con 179 sujetos que recibieron trombólisis. Todos los estudios cumplieron con los requisitos mínimos de calidad de publicación, con un número total de pacientes por año de 7,5 a 12. El periodo de estudio más corto fue de dos años y el más largo de ocho años. Entre cuatro ciudades encontradas se estableció que un total de 30 pacientes por año recibió el tratamiento. Tan solo en dos estudios se pudo establecer el porcentaje de pacientes trombolizados en su población, porcentaje que oscilaba entre 9,5 y 17,5 %. El tiempo puerta aguja promedio de los estudios fue de 124,8 min (DE ± 64,1). A los 90 días se obtuvo un promedio de 58,3 % de escala de Rankin modificada entre 0 y 2 puntos. CONCLUSIÓN: en Colombia existe un subregistro de trombólisis. Es necesario tener un registro nacional de ACV que permita contar con la información para la toma de decisiones en políticas en salud.
Improved Ontology-Based Semantic Search for Open Data

As governments publish more datasets, potential users need a way of finding the datasets they desire. This is not always so easy. Special domain-specific terminology may seem obvious to the dataset publishers, but is likely not so obvious to the users looking for datasets. Existing keyword-based search approaches therefore leave some room for improvement, since they require that queries mention words from the dataset metadata. Efforts have been made to help solve this problem. Hagelien’s thesis serves as a basis for this thesis, and presented a prototype for ontology-based semantic search called DataOntoSearch. His approach is to match the user’s query with concepts in an ontology, which are then matched with datasets based on either an automatic or a manual association between datasets and concepts. By using concepts as an intermediate layer, the user’s query is more likely to match with datasets that are related without mentioning the specific words used by the user. Other efforts include Google Dataset Search, which was introduced in September 2018. Their system works much like the regular Google search, letting you search for datasets independent of where they are published, but it exhibits the same traits as other keyword-based search engines. Another approach uses the semantic web to let the user specify a time period and geographical area by using terms known to the them, rather than specific dates and coordinates. Even then, it does not look like any approach exists using an ontology for open data search. This thesis poses two research questions: What problems are there in DataOntoSearch, and how can we address these issues? A usability test showed that the search did not return what users search for, and looked unprofessional. The users were more impressed by Google Dataset Search. Based on these findings and other observations about DataOntoSearch, I have developed a version 2 of the system, where it has been made 1) ready to set up and deploy 2) interoperable with web APIs 3) integrated with a common dataset archival solution (CKAN) 4) hopefully more usable and 5) better for searching . Specifically, while version 1 had an F1 score of 6% and a MAP measure of 3%, version 2 has an F1 score of 35% and a MAP measure of 32% using the manually created dataset-concept associations. Though Google Dataset Search was included in the evaluation and scored a lower than DataOntoSearch version 2, it suffered from a bug that day which made it not perform as well as it has performed other days. Overall, the ontology-based semantic search approach is promising, and may very well help solve the problem of making open datasets discoverable. With the contributions of this thesis, DataOntoSearch is better poised to serve its purpose “out in the wild” than ever before, and has a greater chance of being adapted and make a difference for users wishing to find a dataset to solve their problems.
Effects of 37˚C Carbon Dioxide Pneumoperitoneum on Core Body Temperature, Systolic Blood Pressure, Heart Rate and Acid-Base Balance: A Randomized Double-blind Controlled Trial

Purpose: The purpose of this study was to compare the effects of 21 ̊C CO2 and 37 ̊C CO2 pneumoperitoneum on body temperature, blood pressure, heart rate, and acid-base balance. Methods: Data were collected at a 1300-bed university hospital in Incheon, from February through September 2012. A total of 74 patients who underwent laparoscopic colectomy under general anesthesia with desflurane were randomly allocated to either a control group or an experimental group. The control group received 21 ̊C CO2 pneumoperitoneum; the experimental group received 37 ̊C CO2 pneumoperitoneum. The pneumoperitoneum of the two groups was under abdominal pressure 15 mmHg. Body temperature, systolic blood pressure, heart rate and acid-base balance were assessed at 30 minutes and 90 minutes after pneumoperitoneum, and again at 30 minutes after arriving at the Post Anesthesia Care Unit. Results: Body temperature in the 37 ̊C CO2 pneumoperitoneum group was significantly higher (F= 9.43, p < .001) compared to the 21 ̊C CO2 group. However, there were no statistically significant differences in systolic blood pressure (p = .895), heart rate (p = .340), pH (p = .231), PaCO2 (p = .490) and HCO3(p = .768) between the two groups. Conclusion: Pneumoperitoneum of 37 ̊C CO2 is effective for the increase of body temperature compared to pneumoperitonium of 21 ̊C CO2, and it does not result in a decrease of blood pressure, heart rate or acid-base imbalance.
Prevalence of Anxiety and Depressive Symptoms and Its Association With Multimorbidity Among Adults in Karachi

One in four people struggle with mental disorders (WHO, 2003). Depression has been fourth leading cause of disease burden. It is predicted that it will be the second leading cause of disability and death by 2020. (O'Connor , 2013) . Literature reports that 40-68% of the population between the ages of 18 to 84 with Multimorbidity reported Anxiety and Depressive symptoms, ( Roca et al., 2009). The burden of Anxiety and Depression with Multimorbidity lead to increased rate of health care utilization, reduced life expectancy and poorer health outcomes. (Smith et al., 2014) BACKGROUND
Biological Factors Responsible to the Failure of Osseointegrated Dental Implants

In the last few decades, the field of dental implantology is advancing significantly, leading to more predictable treatments for the rehabilitation of fully and partially edentulous patients. Owing to the remarkable success, there have been various researches going on to find out factors responsible for the failure of implants. The present review is aimed at individuating factors associated with biological factors of osseointegrated oral implants. The factors contributing to failure of osseointegration have been identified as medical status of the patient, smoking, bone quality, bone grafting, irradiation, bacterial contamination, lack of preoperative antibiotics, degree of surgical trauma, and operator experience. Furthermore, it appears that implant surface properties, roughness and premature loading influence the failure pattern the ability to anticipate outcomes is an essential part of risk management in an implant practice. Recognizing conditions that place the patient at a higher risk of failure will allow the surgeon to make informed decisions and refine the treatment plan to optimize the outcomes.
On Sanskruti and harmonic index of a certain graph structure

Graph theory is a delightful playground for the evaluation of proof, techniques in Discrete Mathematics and its results have applications in several areas of sciences. For a molecular graph, a numeric quantity that characterizes the complete formation of a graph is called a topological index. Topological indices are most helpful in the field of isomer discrimination, chemical validation, QSAR, QSPR, and pharmaceutical drug design. There are certain types of topological indices like distance-based, degree-based and counting related topological indices. In our work, we calculate and analyze the degree-based topological indices like 𝑀 𝑟 (𝐺) , GA(G), 𝑂𝐺𝐴 𝑟 (𝐺) , GAII(G), SK, 𝑆𝐾 1 , 𝑆𝐾 2 , H(G), 𝐻 𝑟 (𝐺) , 𝜆(𝐺) , 𝜆 𝑟 (𝐺) , F(G), 𝐺𝐴 5 (𝐺) and the Sanskruti index for the web Graph. Furthermore, we give closed analytic results of these indices.
Increased reproductive output of Danish red fox females following an outbreak of canine distemper

A decline in the Danish population of red foxes Vulpes vulpes due to an outbreak of canine distemper (CDV) in 2012 gave us the opportunity to test the hypothesis that the reproductive performance of foxes increases when the population density declines. The reproductive performance of 280 female foxes from two periods (mainly shot or road killed) in 1997-2000 and 2012-16, were compared. Game Bag Records of Jutland (GBRJ) were used as an estimate of population density. After a drop in GBRJ in 2013 due to the CDV epidemic, the mean litter size (based on dark placental scars from partum to oestrus) became significantly larger than in previous years; F=4.3, p>0.03, Hc=8.1, p<0.02. In 2015-2016, after population decline the mean litter size was 8.2 (±2.5 SD) and in the breeding seasons before population decline in 1997-1999 and 2012-2013 the mean litter size was 5.6 (±2.1 SD) and 5.7 (±2.0 SD), respectively. During the period 1997-1999, barrenness was relatively high especially in yearlings, and the reproducing yearling foxes made up only 6% of the breeding females compared to 2012-13 and 2015-16 where breeding yearling females made up 53% and 61%, respectively. Age related differences in litter size and productivity were found in years with a relatively high population density, when older females in their third and fourth breeding seasons had the largest litter sizes and highest productivity. This was in contrast to the years with low population size, when no age-related reproduction was found, and when young females had relatively large litter sizes and high productivity. Rump fat thickness (RFT) of the breeding females was significantly higher in breeding females than in barren females, and the RFT was positively correlated to the number of embryos (R=41%). This study confirms that the number of barren females drops, and the proportion of yearling females and litter size increase with reduced population density. Hence, culling or epidemics in fox populations increase production, most probably due to reduced competition among foxes, but will not change population size permanently. The present level of culling and traditional hunting in Denmark has no long-term effect on population size.
Examining the Pueblo II–III Transition in the Moapa Valley, Southern Nevada

Based on the limited data available to her at the time, Margaret Lyneis proposed that the transition between the Pueblo II and Pueblo III periods in the Moapa Valley was marked by differences in social organization and subsistence strategies. Since then, additional data have become available from new archival research and excavations, making it possible to more fully investigate the ideas presented by Lyneis. In this paper, the newly-available data are used to re-evaluate the nature of the Pueblo II–III transition, and their implications for understanding the terminal Virgin Branch occupation of the Moapa Valley are considered.
Generalizability of “GWAS hits” in clinical populations: Lessons from childhood cancer survivors

With mounting interest in translating GWAS hits from large meta-analyses (meta-GWAS) in diverse clinical settings, evaluating their generalizability in target populations is crucial. Here we consider long-term survivors of childhood cancers from the St. Jude Lifetime Cohort Study and show the limited generalizability of 1,376 robust SNP associations reported in the general population across 12 complex anthropometric and cardiometabolic phenotypes (N=2,231; observed-to-expected replication ratio=0.68, P=2.4×10−9). An examination of five comparable phenotypes in a second independent cohort of survivors from the Childhood Cancer Survivor Study corroborated the overall limited generalizability of meta-GWAS hits to survivors (N=4,212, observed-to-expected replication ratio=0.53, P=1.1×10−16). Meta-GWAS hits were less likely to be replicated in survivors exposed to cancer therapies associated with phenotype risk. Examination of complementary DNA methylation data in a subset of survivors revealed that treatment-related methylation patterns at genomic sites linked to meta-GWAS hits may disrupt established genetic signals in survivors.
Reconstruction of the palate using a vascularized bare muscle flap following total maxillectomy: A case report

Abstract Reconstruction following total or subtotal maxillectomy requires specialized techniques, and it is still a challenge for surgeons. This case report describes a 55-year-old male patient with maxillary cancer. He underwent right total maxillectomy and left partial maxillectomy. He underwent reconstruction using a latissimus dorsi free flap combined with a vascularized scapula angle. For palatal reconstruction, we used a bare muscle flap following rigid bony reconstruction. The reconstructed palate became contracted and covered with mucosa gradually and resulted in a physiologically satisfying contour. The histological features of the reconstructed site revealed normal stratified squamous epithelium. The bare muscle flap is considered the preferred method for palatal reconstruction following total or subtotal maxillectomy.
Movilizaciones estudiantiles y liderazgo directivo: un estudio exploratorio en tres liceos de la Región Metropolitana

The study of student mobilizations in Chile has focused on a structural perspective or on the meaning assigned to them by students. Therefore, the objective of the study is to understand how these movements are experienced within the educational communities and how they are managed by the school leadership. The research was conducted through case studies in three schools in the Santiago Metropolitan Region that have experienced mobilizations since 2006, with in-depth interviews and content analysis. The study is inserted in a perspective that emphasizes macropolitical and micropolitical components, delves into the socio-educational conflicts and explores educational leadership practices. The results identify a "normalization" of these socio-educational conflicts and emphasize their relational consequences. In addition, its management is recognized as a school director’s central, yet unrecognized, task. The results also highlight the lack of tools, the political preponderance of the school administrator or superintendent, and the intermediating role of the Student Center’s mentor teachers. Finally, a set of learning and leadership practices are identified for a more constructive management performed by the school leadership.
Graphene Nanowire Based TFETs

The present work is aimed at improving the performance potential of tunnel field effect transistors (TFETs), where the carriers are transported by the process of band to band tunneling. The nanoscale TFETs serves the purpose of ULSI integration with high speed and memory. The requirements of new device technology are challenging: for logical switching. In this paper, a p-channel graphene nanoribbon (GNR) TFETs has been analyzed and designed for low power and high performance digital switching application. The energy band diagram of the device is obtained from self-consistent iterative method for numerical solution of one-dimensional Poisson ’ s equation subject to appropriate boundary conditions. It is observed that the optimized p + channel GNR TFET provides high ON – OFF current ratio, low sub-threshold slope for a channel length of 85 nm and channel width of 4 nm.
Dissociated responses to caloric and head impulse stimulation in a case of isolated vestibule-lateral semicircular canal dysplasia

Abstract Isolated vestibule-lateral semicircular canal dysplasia (LSCCD) is one of the most common inner ear malformations. We present a case of a 59-year-old patient with right vestibule-lateral canal dysplasia and a history of spontaneous vertigo spells without hearing loss. Vestibular assessment showed a dissociation between caloric responses and vestibulo-ocular reflex gain as measured with the video head-impulse test.
Navy text data set equalization method based on deep learning

Traditional unbalanced data sets, such as artificial set processing method, exists in the complicated and poor universality. It is difficult to apply naval uneven text data set processing. Aiming at this problem, this paper proposes a Navy uneven text data processing model based on biRNN. It learns text sequence features through biRNN model. Then it generates text similar to the original to balance text data. Text classification experiments are carried out on original data set and balanced data set respectively. The experimental results show that balancing the original data set based on biRNN method can effectively improve the performance of text classification.
Silver nanoparticles affect germination and photosynthesis in tobacco seedlings

Extensive commercialization of silver nanoparticles (AgNPs) raises the risk of their accumulation in the soil-plant system. Once released into the environment, AgNPs are prone to chemical transformations, which make it hard to determine whether their phytotoxic effects are purely NP-related or a consequence of released Ag+ ions. In this study the effects of 25, 50, 75, 100 and 150 μM AgNPs and AgNO3 on seed germination and early growth of tobacco (Nicotiana tabacum L.) seedlings were compared. Additionally, the effects on photosynthetic performance and pigment content were investigated. Germination rate and index values indicated delayed and slower germination in some AgNP treatments. Lower AgNP concentrations stimulated root growth, but induced a prominent reduction in fresh weight. By contrast, all AgNO3 concentrations inhibited root growth but only the higher ones decreased fresh weight. Obtained results imply that the observed AgNP toxicity could be ascribed to NP form and can be correlated with high AgNP stability in the solid medium. On the other hand, the majority of AgNP and AgNO3 treatments induced an increase in chlorophyll content that was accompanied by significantly lower values of relative electron transport rate and coefficient of photochemical quenching, implying an inhibition of the electron transport chain. A similar impact of AgNPs and AgNO3 on photosynthesis can be correlated with lower stability of AgNPs in a liquid medium, resulting in AgNP aggregation and dissolution of Ag+ ions.