Miracle-dz/UniFAR-FTUs huggingface dataset:
Gold Price Forecast Based on LSTM-CNN Model

An accurate prediction is certainly significant in financial data analysis. Investors have used a series of econometric techniques on pricing, stock selection and risk management but few of them have found great success due to the fact that most of them only are purely based on a single scheme. Recent advances in deep learning methods have also demonstrated the outstanding performance in the fields of image recognition and sentiment analysis. In this paper, we originally propose a novel gold price forecast method based on the integration of Long Short-Term Memory Neural Networks (LSTM) and Convolutional Neural Networks (CNN) with Attention Mechanism (denoted to LSTM-Attention-CNN model). Particularly, the LSTM-Attention-CNN model consists of three components: the LSTM component, Attention Mechanism and the CNN component. The LSTM component enables to harness the sequential order of daily gold price. Meanwhile, the Attention Mechanism assigns different attention weights on the new encoding method from LSTM component to enhance the extraction of the temporal and spatial features. In addition, the CNN component enables to capture the local patterns and abstract the spatial features. Extensive experiments on real dataset collected from World Gold Council show that our proposed approach outperforms other conventional financial forecast methods.
Characterization of Listeria monocytogenes Originating from the Spanish Meat-Processing Chain

Using agglutination techniques, 118 Listeria monocytogenes isolates from red meat and poultry were serotyped. Strains were ascribed to the serotypes 4b/4e (44.1% of the strains), 1/2 (a, b or c; 28.0%), 4c (6.8%), 4d/4e (5.9%) and 3 (a, b or c; 2.5%). Among these are the serotypes most frequently involved in cases of human listeriosis. The susceptibility of 72 strains to 26 antibiotics of clinical importance was determined by disc diffusion (Clinical and Laboratory Standards Institute; CLSI). High levels of resistance were observed to cefoxitin (77.8% of the strains showed resistance), cefotaxime (62.5%), cefepime (73.6%), nalidixic acid (97.2%), nitrofurantoin (51.4%) and oxacillin (93.1%). Less than 3% of the strains showed resistance to the antibiotic classes used in human listeriosis therapy (i.e., ampicillin, gentamicin, rifampicin, chloramphenicol, enrofloxacin, vancomycin, trimethoprim-sulfamethoxazole, erythromycin, and tetracycline). The influence of species and serotype on the growth kinetics (modified Gompertz equation) and on the adhesion ability (crystal violet staining) of nine isolates of L. monocytogenes (serotypes 1/2a, 1/2b, 1/2c, 3a, 3b, 3c, 4a, 4b, and 4d), and one strain of Listeria ivanovii were investigated. The maximum growth rate (ΔOD420-580/h) varied between 0.073 ± 0.018 (L. monocytogenes 1/2a) and 0.396 ± 0.026 (L. monocytogenes 4b). The isolates of L. monocytogenes belonging to serotypes 3a and 4a, as well as L. ivanovii, showed a greater (p < 0.05) biofilm-forming ability than did the remaining strains, including those that belong to the serotypes commonly implied in human listeriosis (1/2a, 1/2b, 1/2c and 4b). The need for training in good hygiene practices during the handling of meat and poultry is highlighted to reduce the risk of human listeriosis.
eview etting a handle on embryo limb development : Molecular nteractions driving limb outgrowth and patterning

Development of the vertebrate embryo involves multiple segmentation processes to generate a functional, articulated organism. Cell proliferation, differentiation and patterning involve spatially and temporally regulated gene expression and signal transduction mechanisms. The developing vertebrate limb is an excellent model to study such fine-tuned regulations, whereby cells proliferate and are dif-
Positioning Analysis: A model for assessing change processes in group activities

The paper presents a research aimed to demonstrate a possible application of the positioning analysis as a tool f r evaluating the processes of change in group activities. The positi oning analysis takes shape within the theoretical framework of post-mode rn social sciences, and is proposed as a dynamic alternative to the traditi onal static concept of role and identity. In order to test the proposed mo del, a group activity was investigated. The activity consisted of various wor kshops whose purpose was to investigate the social construction of ident ity and gender, in the context of urban security and gender violence. The results show good prospects for the Positioning Analysis in capturing the processes of change taking place in group activities and offer some int eresting ideas for further applications.
2 MARKOV MODEL OF CODON SUBSTITUTION

This chapter reviews statistical methods for detecting adaptive molecular evolution by comparing synonymous and nonsynonymous substitution rates in protein-coding DNA sequences. A Markov process model of codon substitution, which forms the basis for all later discussions in this chapter, is introduced first. The case of comparing two sequences to estimate the numbers of synonymous (dS) and nonsynonymous (dN) substitutions per site is then considered. The maximum likelihood (ML) method and a number of ad hoc counting methods are evaluated. The rest of the chapter deals with joint analyses of multiple sequences on a phylogeny. Review is done on Markov models of codon substitution that allow the nonsynonymous/synonymous rate ratio (ω = dN/dS) to vary among branches in a phylogeny or among amino acid sites in a protein. Those models can be used to construct likelihood ratio tests (LRTs) to identify evolutionary lineages under episodic Darwinian selection or to infer critical amino acids in a protein under diversifying selection. Real-data examples are used to demonstrate the application of the methods. The chapter finishes with a discussion of the limitations of current methods.
razil nut conservation through shifting cultivation aulo

The regeneration of Brazil nut trees depends on tree-fall gaps in the forest. However, shifting cultivation fallows also create comparable biotic and abiotic opportunities for the dispersion and establishment of this gap-loving species. At the same time, the ability of Brazil nut trees to resprout enables fallow individuals to survive successive slash-and-burn cycles. Recognizing the importance of shifting cultivation for the food security of forest dwellers, we investigated whether the high level of Brazil nut regeneration found in cultivation fallows could be explained by the resprouting capability of Brazil nut trees, the number of cultivation cycles, past agricultural use and distance to the nearest conspecific productive adults. We found that the Brazil nut tree population density increased from 8.86 trees ha−1 to −1 −1 egeneration dynamics
Nanocomposites SnO2/SiO2:SiO2 Impact on the Active Centers and Conductivity Mechanism

This paper is focused on the effect of the stabilizing component SiO2 on the type and concentration of active sites in SnO2/SiO2 nanocomposites compared with nanocrystalline SnO2. Previously, we found that SnO2/SiO2 nanocomposites show better sensor characteristics in CO detection (lower detection limit, higher sensor response, and shorter response time) compared to pure SnO2 in humid air conditions. Nanocomposites SnO2/SiO2 synthesized using the hydrothermal method were characterized by low temperature nitrogen adsorption, XRD, energy dispersive X-ray spectroscopy (EDX), thermo-programmed reduction with hydrogen (TPR-H2), IR-, and electron-paramagnetic resonance (EPR)-spectroscopy methods. The electrophysical properties of SnO2 and SnO2/SiO2 nanocomposites were studied depending on the oxygen partial pressure in the temperature range of 200–400 °C. The introduction of SiO2 results in an increase in the concentration of paramagnetic centers Sn3+ and the amount of surface hydroxyl groups and chemisorbed oxygen and leads to a decrease in the negative charge on chemisorbed oxygen species. The temperature dependences of the conductivity of SnO2 and SnO2/SiO2 nanocomposites are linearized in Mott coordinates, which may indicate the contribution of the hopping mechanism with a variable hopping distance over local states.
Next-Generation Sequence Databases: RNA and Genomic Informatics Resources for Plants1[OPEN]

Tools and approaches for plant small RNA and mRNA data visualization and analysis were developed, taking advantage of numerous sequenced genomes, and integrating tools for RNA analysis with these genomes. We developed public web sites and resources for data access, display, and analysis of plant small RNAs. These web sites are interconnected with related data types. The current generation of these informatics tools was developed for Illumina data, evolving over more than 15 years of improvements. Our online databases have customized web interfaces to uniquely handle and display RNA-derived data from diverse plant species, ranging from Arabidopsis (Arabidopsis thaliana) to wheat (Triticum spp.), including many crop and model species. The web interface displays the abundance and genomic context of data for small RNAs, parallel analysis of RNA ends/degradome reads, RNA sequencing, and even chromatin immunoprecipitation sequencing data; it also provides information about potentially novel transcripts (antisense transcripts, alternative splice isoforms, and regulatory intergenic transcripts). Numerous options are included for downloading data as tables or via web services. Interpretation of these data is facilitated by the inclusion of extensive repeat or transposon data in our genome viewer. We have developed graphical and analytical tools, including a new viewer and a query page for the analysis of phased small RNAs; these are particularly useful for understanding the complex small RNA pathways of plants. These public databases are accessible at https://mpss.danforthcenter. org.
Habitat Use by Desert Tortoises (Gopherus agassizii) on Alluvial Fans in the Sonoran Desert, South-Central Arizona

Abstract Desert Tortoises (Gopherus agassizii) in the Sonoran Desert typically occur on rocky slopes and bajadas and are absent from intermountain valley floors. Tortoises also occur along deeply incised washes emanating from rocky bajadas, using caliche caves as shelter sites. The Florence Military Reservation (FMR), in south-central Arizona, is typified by gently sloping alluvial fans bisected by steeply incised washes. One 10.9-ha hill consisting of volcanic outcrops and boulders occurs at the northern end of the reservation. Tortoise locations at FMR were concentrated around incised washes with dense caliche caves or near the volcanic hill. Home ranges of male and female tortoises were not significantly different, and the sexes used shelter types similarly. Tortoises used caliche caves as shelter more than other shelter types, especially those tortoises without access to the rocky hill. Compositional analysis of the three principal habitat types used by tortoises at FMR revealed that they selected incised washes over the other habitat types. However, we did not find tortoises in washes with few caliche caves. These results suggest that availability of shelter sites strongly influences tortoise distribution at FMR.
Diverse virtual social networks: implications for remote software testing teams

This paper evaluates offshore outsourcing in the IT testing industry and determines what conditions determine its success. There is particular focus on the influence of diversity in teams on group relationships. Two studies are described: the first, investigated the perceptions of professional software testers on the critical factors of offshore outsourcing; and the second study looked at the ability for diverse teams to form close working relationships through virtual networks. We find that overt diversity factors inhibit interaction across nationality boundaries. The limitations of virtual networks for fostering personal communications is apparent in preventing group members from overcoming the initial aversion to mix with out-group members, which could be achieved with closer and more personal communications between members with different diversity factors in normal face to face communications. Where software testing teams are outsourced globaly, and must rely on virtual communications, there seems potential for significant difficulties in developing close working relationships, which on the one hand, can be negative for group cohesion, but one the other hand, can be positive for encouraging imparitality.
Coupled Genome-Wide DNA Methylation and Transcription Analysis Identified Rich Biomarkers and Drug Targets in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) has poor clinical prognosis. Lack of TNBC-specific biomarkers prevents active clinical intervention. We reasoned that TNBC must have its specific signature due to the lack of three key receptors to distinguish TNBC from other types of breast cancer. We also reasoned that coupling methylation and gene expression as a single unit may increase the specificity for the detected TNBC signatures. We further reasoned that choosing the proper controls may be critical to increasing the sensitivity to identify TNBC-specific signatures. Furthermore, we also considered that specific drugs could target the detected TNBC-specific signatures. We developed a system to identify potential TNBC signatures. It consisted of (1) coupling methylation and expression changes in TNBC to identify the methylation-regulated signature genes for TNBC; (2) using TPBC (triple-positive breast cancer) as the control to detect TNBC-specific signature genes; (3) searching in the drug database to identify those targeting TNBC signature genes. Using this system, we identified 114 genes with both altered methylation and expression, and 356 existing drugs targeting 10 of the 114 genes. Through docking and molecular dynamics simulation, we determined the structural basis between sapropterin, a drug used in the treatment of tetrahydrobiopterin deficiency, and PTGS2, a TNBC signature gene involved in the conversion of arachidonic acid to prostaglandins. Our study reveals the existence of rich TNBC-specific signatures, and many can be drug target and biomarker candidates for clinical applications.
Structural complementarity of distance constraints obtained from chemical cross‐linking and amino acid coevolution

The analysis of amino acid coevolution has emerged as a practical method for protein structural modeling by providing structural contact information from alignments of amino acid sequences. In parallel, chemical cross‐linking/mass spectrometry (XLMS) has gained attention as a universally applicable method for obtaining low‐resolution distance constraints to model the quaternary arrangements of proteins, and more recently even protein tertiary structures. Here, we show that the structural information obtained by XLMS and coevolutionary analysis are effectively complementary: the distance constraints obtained by each method are almost exclusively associated with non‐coincident pairs of residues, and modeling results obtained by the combination of both sets are improved relative to considering the same total number of constraints of a single type. The structural rationale behind the complementarity of the distance constraints is discussed and illustrated for a representative set of proteins with different sizes and folds.
Identifying children who are susceptible to dropping out from physical activity and sport: a cross-sectional study

ABSTRACT BACKGROUND: Although the benefits of physical activity are clear, adherence to physical activity programs is a challenge, especially during transitional phases of life. OBJECTIVE: We aimed to identify adolescents who were more likely to drop out from physical activity and sports participation, from childhood to adolescence. DESIGN AND SETTING: This was a cross-sectional study on retrospective data regarding childhood activity among 803 Brazilian adolescents. The study was conducted at public schools in Londrina, Paraná, in 2011. METHODS: Habitual physical activity, sports participation during childhood, parental physical activity, socioeconomic status and perception of social relationships were self-reported. Cardiorespiratory fitness was estimated via a 20-m shuttle-run test and somatic maturation was estimated from the age at peak height velocity. RESULTS: Our results provided evidence that girls (physical activity: odds ratio, OR: 4.37 [95% confidence interval, CI: 1.86-10.3]; sports: OR: 2.65 [95% CI: 1.39-5.05]) and adolescents with low cardiorespiratory fitness (physical activity: OR: 1.77 [95% CI: 1.13-2.78]; sports: OR: 1.62 [95% CI: 1.15-2.26]) were more likely to drop out from active behaviors. Children with inactive mothers and inactive fathers (OR: 3.55 [95% CI: 1.12-11.3]) also showed a higher dropout rate from physical activity. Adolescents with negative perceptions of friendships (OR: 2.33 [95% CI: 1.21-4.47]) were more likely to drop out from sports. CONCLUSIONS: Higher dropout rates from active lifestyles during childhood were observed among girls and adolescents with low cardiorespiratory fitness. Parental inactivity and negative perceptions of friendships were also potential risk factors for discontinuation of childhood physical activity and sports.
Intraocular chemotherapy for vitreoretinal lymphoma: A review

Vitreoretinal lymphomas are rare ocular cancers, and the subset of primary central nervous system lymphomas that are based in the posterior eye. These tumours are challenging to treat, and today management generally involves a multispecialty team coordinating a treatment protocol that may include intraocular chemotherapy, ocular irradiation, systemic chemotherapy and/or autologous stem cell transplantation. The ophthalmologist has specific responsibility for the intraocular chemotherapy, which is delivered to the eye by intravitreal injection. The most commonly injected drugs are methotrexate—an anti‐metabolite—and rituximab—an anti‐human B cell monoclonal antibody. A range of intraocular chemotherapy treatment schedules have been described in the medical literature, although to date there have been no randomized clinical trials of these schedules. In this article, we review the development and current status of intraocular chemotherapy for vitreoretinal lymphoma.
Early Alendronate Can Be Safe during Fracture Healing?

I read the article by Duckworth and colleagues with great interest, especially as the JBMR June 2019 cover highlights “Alendronate Safe During Fracture Healing. ” The study shows that early use of alendronate, starting around 10 days after fracture, does not affect healing at 2, 4, 6, and 8 weeks and presumably also at 24 weeks. Malunion after a wrist fracture was determined by “measuring dorsal angle, carpal alignment, and radial shortening and was declared to exist when there was carpal malalignment with less than neutral dorsal tilt and/or more than 3 mm of radial shortening. ” The clinical DASH index was recorded, but bone strength was not assessed. Also, bone turnover markers were not measured, even though they can be informative, as they are expected to be elevated during the healing process. Even though bisphosphonates are likely to accumulate rapidly at fracture sites, their antiresorptive effect may not be maximal until 3 months of treatment. The authors rightfully stated that they cannot determine the long-term effect of bisphosphonate therapy on bone healing because the trial did not go beyond 26 weeks. Likewise, patients who started on treatment within 2 years of fracture were excluded from the study. Previous studies, however, have shown that fracture healing was delayed in current bisphosphonate users compared with naïve patients. The reasons for starting a bisphosphonate before healing is complete is to prevent early additional fractures, which can occur after a vertebral fracture. However, such early secondary fractures are less likely to occur in long bones, if not associated with obvious risks for falling. Furthermore, a recent study showed bisphosphonates have little effect on healing new fracture after suffering an acute osteoporotic spine fracture compared with placebo. Therefore, based on the available evidence, it would seem prudent to delay antiresorptive therapy with bisphosphonates or at least withhold the current treatment until there is radiographic evidence of fracture healing to avoid reducing bone remodeling and thus conversion of soft callus to solid bone. Because of this, the cover page highlight probably should read “Early Alendronate Can Be Safe During Fracture Healing,” as this is the only conclusion supported by evidence in the article.
An Integrated Multi-Sensor Approach for the Remote Monitoring of Parkinson’s Disease

The increment of the prevalence of neurological diseases due to the trend in population aging demands for new strategies in disease management. In Parkinson’s disease (PD), these strategies should aim at improving diagnosis accuracy and frequency of the clinical follow-up by means of decentralized cost-effective solutions. In this context, a system suitable for the remote monitoring of PD subjects is presented. It consists of the integration of two approaches investigated in our previous works, each one appropriate for the movement analysis of specific parts of the body: low-cost optical devices for the upper limbs and wearable sensors for the lower ones. The system performs the automated assessments of six motor tasks of the unified Parkinson’s disease rating scale, and it is equipped with a gesture-based human machine interface designed to facilitate the user interaction and the system management. The usability of the system has been evaluated by means of standard questionnaires, and the accuracy of the automated assessment has been verified experimentally. The results demonstrate that the proposed solution represents a substantial improvement in PD assessment respect to the former two approaches treated separately, and a new example of an accurate, feasible and cost-effective mean for the decentralized management of PD.
Online Scheme Towards Secured Inter Banking Fund Transfer

On-line fund transfer is becoming an important constituent of today’s business need. However, most of the existing frameworks for on-line money transfer require sharing of some private information among involved parties and consequently tempts potentially high risks. Implementation of these schemes also requires significant overhaul of the existing infrastructure. In this paper, we propose a reliable scheme for secured online interoperable fund transfer among banking institutions. In our approach, we facilitate minimal sharing of individual user’s private data among banking institutions and eliminate the urge of complete overhaul of any existing framework for its implementation. The proposed scheme is based on loosely coupled service orientation using SOAP and web services with exchange of documents of open standards like XML. The approach has inherent capability of providing authenticity and higher security with protection of confidentiality of information involved in the transfer at an affordable computational time.