Miracle-dz/UniFAR-FTUs huggingface dataset:
Millimeter-Wave Substrate Integrated Dual Level Gap Waveguide Horn Antenna

Substrate integrated H-plane horn antenna design is introduced based on elevated substrate integrated gap waveguide (E-SIGW) configuration. The E-SIGW topology allows designing the horn from two substrates of different thicknesses. A thin substrate for the feed line to eliminate the radiation losses and a thicker one for the radiating aperture. The proposed configuration allows the H-plane horn aperture to be three times thicker than the feed line substrate, which is not possible with the conventional substrate integrated waveguide technology. The transition between the horn layers enhances the matching bandwidth without any aperture modification. The outer surface of the horn around its aperture is loaded with soft surfaces realized by transverse strips. As a result, more symmetric fan beam radiation patterns with suppressed back lobes are achieved.
Chemokine Receptor CCR3 Function Is Highly Dependent on Local pH and Ionic Strength*

The CC chemokine receptor 3 (CCR3) plays an important role in the regulation of the migration of eosinophils, a leukocyte population involved in many inflammatory pathologies including asthma. CCR3 binds to the CC chemokine eotaxin, a promigratory cytokine originally isolated as the key component in a model of eosinophil-induced airway inflammation. We show here that eotaxin/CCR3 binding interactions exhibit a marked sensitivity to relatively small changes in the extracellular environment. In particular, modest variations in the pH and the level of sodium chloride over a range of physiologic and near physiologic conditions had dramatic effects on eotaxin binding and CCR3-mediated cytoplasmic Ca2+ mobilization. These biochemical indices were reflected at the functional level as well; small changes in pH and salt also resulted in striking changes in the migration of primary human eosinophils in vitro. These results reveal that relatively small perturbations in extracellular buffer conditions can yield widely disparate interpretations of CCR3 ligand binding and affinities and suggest that modulation of the tissue microenvironment might be utilized to control the affinity and efficacy of chemokine-mediated cell migration.
Domain‐specific Market Segmentation

Proposes domain‐specific market segmentation as a promising approach as compared with segmentation based on general or on brand‐specific variables. Treats product differentiation and positioning as the counterpart of market segmentation. The link between market segmentation, on the one hand, and product differentiation, on the other hand, is the product benefit. The product benefit is the interaction of the product and the consumer.
Spousal Loss and Weathering : Mitigation by Religious Attendance ?

Objectives: This study queried linkages of older adults’ religious attendance with their physiological health. Method: Data were from the 2005–2006 National Social Life, Health, and Aging Project, nationally representative of U.S. adults aged 57–85 years. Analyses examined associations of religious attendance with biological states, potential gender variations in these linkages, and attenuation by this factor of health effects of spousal loss. Results: Religious attendance was negatively associated with a system of physiological issues, consistent with mitigation of multisystemic “weathering. ” Linkages were relatively uniform with inflammatory and cardiovascular but not metabolic states and were not significantly different for women than men. Effects of spousal loss on the 2 former subsystems were attenuated by regular religious attendance—in combined-gender analysis and among women, but not men. Discussion: Religious attendance may buffer older adults from physiological problems and the health effects of life events such as spousal loss. More intensive analysis is needed to explain differential linkages with specific biological subsystems.
Antidiabetic zinc(II)‐N ‐acetyl‐L‐cysteine complex: Evaluations of in vitro insulinomimetic and in vivo blood glucose‐lowering activities

The diabetic state is known to induce oxidative stress in its mechanism, which in turn is responsible for the complications of diabetes mellitus (DM). Recently, we found that Zn(II) complexes have in vitro insulinomimetic and in vivo blood glucose‐lowering activities. During our study on the development of new Zn(II) complexes with antioxidative ligands involving L‐cysteine, L‐cysteine‐methylester, and N‐acetyl‐L‐cysteine (nac), we found a new (N‐acetyl‐L‐cysteinato)Zn(II) (Zn(nac)) complex by evaluating of both its in vitro insulinomimetic and in vivo potencies. The insulinomimetic activity of Zn(nac) with respect to the inhibition of free fatty acid release in isolated rat adipocytes treated with epinephrine was higher than that of a well‐known insulinomimetic VOSO4, being equivalent to that of ZnSO4 . The blood glucose level of hyperglycemic KK‐Ay mice with type 2 DM was reduced by daily intraperitoneal injections of Zn(nac) for 28 days. Their serum insulin, HbA1c, TCHO, and UN levels were remarkably decreased, indicating that Zn(nac) improved the insulin resistance of the mice. The improvement of DM by Zn(nac) was also confirmed by the oral glucose tolerance test. In conclusion, Zn(nac) complex is proposed to attenuate both hyperglycemia and hyperinsulinemia in KK‐Ay mice by decreasing serum insulin, HbA1c, UN, and TCHO levels.
A mixed-structure delay locked-loop with wide range and fast locking

This paper describes an all digital locked-loop (DLL) with a mixed structure of measure-controlled DLL (MCDLL) and register-controlled DLL (RCDLL). The DLL utilized time to digital converter (TDC) and digital to time converter (DTC) using ring counter for wide range operation with small area, fast lock and duty cycle correction (DCC). Simulation results show lock time less than 40 cycles, 1% duty correction error from 50plusmn10% duty external clock, 12mW power dissipation at 800MHz with a 1.5V supply voltage and a wide locking range from 100MHz to 800MHz in a 0.18mum CMOS technology
Host attachment and fluid shear are integrated into a mechanical signal 1 regulating virulence in Escherichia coli O 157 : H 7 2 3 4

24 Enterohemorrhagic Escherichia coli (EHEC) is a food-borne pathogen causing hemorrhagic 25 colitis and hemolytic uremic syndrome. EHEC colonize the intestinal tract, through a range of 26 virulence factors encoded by the locus of enterocyte effacement (LEE) as well as Shiga toxin. 27 Although the factors involved in colonization and disease are well characterized, how EHEC 28 regulates their expression in response to a host encounter is not well understood. Here, we report 29 that EHEC perceives attachment to host cells as a mechanical cue that leads to expression of 30 LEE-encoded virulence genes. This signal is transduced via the LEE-encoded global regulator of 31 Ler, GrlA, and further enhanced by levels of shear force similar to peristaltic forces in the 32 intestinal tract. Our data suggests that, in addition to a range of chemical environmental signals, 33 EHEC is capable of sensing and responding to mechanical cues in order to adapt to its host’s 34 physiology. 35
1 0 Ju l 2 01 7 Localization in random bipartite graphs : numerical and empirical study

We investigate adjacency matrices of bipartite graphs with power-law degree distribution. Motivation for this study is twofold. First, vibrational states in granular matter and jammed sphere packings; second, graphs encoding social interaction, especially electronic commerce. We establish the position of the mobility edge, and show that it strongly depends on the power in the degree distribution and on the ratio of the sizes of the two parts of the bipartite graph. At the jamming threshold, where the two parts have the same size, localization vanishes. We found that the multifractal spectrum is non-trivial in the delocalized phase, but still near the mobility edge. We also study an empirical bipartite graph, namely the Amazon reviewer-item network. We found that in this specific graph mobility edge disappears and we draw a conclusion from this fact regarding earlier empirical studies of the Amazon network.
The impact of a cold chain break on the survival of Salmonella enterica and Listeria monocytogenes on minimally processed 'Conference' pears during their shelf life.

BACKGROUND In recent years, improved detection methods and increased fresh-cut processing of produce have led to an increased number of outbreaks associated with fresh fruits and vegetables. During fruit and vegetable processing, natural protective barriers are removed and tissues are cut, causing nutrient rich exudates and providing attachment sites for microbes. Consequently, fresh-cut produce is more susceptible to microbial proliferation than whole produce. RESULTS The aim of this study was to examine the impact of storage temperature on the growth and survival of Listeria monocytogenes and Salmonella enterica on a fresh-cut 'Conference' pear over an 8 day storage period. Pears were cut, dipped in antioxidant solution, artificially inoculated with L. monocytogenes and S. enterica, packed under modified atmospheric conditions simulating commercial applications and stored in properly refrigerated conditions (constant storage at 4 °C for 8 days) or in temperature abuse conditions (3 days at 4 °C plus 5 days at 8 °C). After 8 days of storage, both conditions resulted in a significant decrease of S. enterica populations on pear wedges. In contrast, when samples were stored at 4 °C for 8 days, L. monocytogenes populations increased 1.6 logarithmic units, whereas under the temperature abuse conditions, L. monocytogenes populations increased 2.2 logarithmic units. CONCLUSION Listeria monocytogenes was able to grow on fresh-cut pears processed under the conditions described here, despite low pH, refrigeration and use of modified atmosphere. © 2016 Society of Chemical Industry.
Home range overlap , matrilineal and biparental kinship drive female associations in bottlenose dolphins

Few studies of kinship in mammalian societies have been able to consider the complex interactions between home range overlap, association patterns and kinship, which have created a critical gap in our understanding of social evolution. We investigated the association patterns of female bottlenose dolphins, Tursiops aduncus, in the eastern gulf of Shark Bay, Western Australia and found that they depended upon the complex interplay of at least three factors: home range overlap, matrilineal kinship and biparental kinship. While home range overlap was positively correlated with female association patterns, preferred associations were found between females showing as little as 27% home range overlap, and some pairs showed avoidance despite 100% home range overlap. Furthermore, on average, both casual and preferred associations took place between females that were more closely biparentally related than expected by chance and this pattern varied depending upon whether or not pairs of females shared the same matriline.
Classification of newly‐onset IDDIM and NIDDIM in subjects aged 25–45 years in Sudan

Elbagir MN, Eltom MA, Berne C (Departments of Internal Medicine, University Hospital, Uppsala, Sweden and Endocrinology and Diabetes Research Centre, Omdurman Teaching Hospital, Omdurman, Sudan). Classification of newly‐onset IDDIM and NIDDIM in subjects aged 25–45 years in Sudan. J Intern Med 1998; 244: 443–50.
Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.

Mammalian DNA (cytosine‐5) methyltransferase contains a C‐terminal domain that is closely related to bacterial cytosine‐5 restriction methyltransferase. This methyltransferase domain is linked to a large N‐terminal domain. It is shown here that the N‐terminal domain contains a Zn binding site and that the N‐ and C‐terminal domains can be separated by cleavage with trypsin or Staphylococcus aureus protease V8; the protease V8 cleavage site was determined by Edman degradation to lie 10 residues C‐terminal of the run of alternating lysyl and glycyl residues which joins the two domains and six residues N‐terminal of the first sequence motif conserved between the mammalian and bacterial cytosine methyltransferases. While the intact enzyme had little activity on unmethylated DNA substrates, cleavage between the domains caused a large stimulation of the initial velocity of methylation of unmethylated DNA without substantial change in the rate of methylation of hemimethylated DNA. These findings indicate that the N‐terminal domain of DNA methyltransferase ensures the clonal propagation of methylation patterns through inhibition of the de novo activity of the C‐terminal domain. Mammalian DNA methyltransferase is likely to have arisen via fusion of a prokaryotic‐like restriction methyltransferase and an unrelated DNA binding protein. Stimulation of the de novo activity of DNA methyltransferase by proteolytic cleavage in vivo may contribute to the process of ectopic methylation observed in the DNA of aging animals, tumors and in lines of cultured cells.
Brain structural substrates of cognitive procedural learning in alcoholic patients early in abstinence.

BACKGROUND Procedural learning allows for the acquisition of new behavioral skills. Previous studies have shown that chronic alcoholism is characterized by impaired cognitive procedural learning and brain abnormalities affecting regions that are involved in the automation of new cognitive procedures in healthy individuals. The goal of the present study was to investigate the brain structural substrates of cognitive procedural learning in alcoholic patients (ALs) early in abstinence. METHODS Thirty-one ALs and 31 control participants (NCs) performed the Tower of Toronto task (4 daily learning sessions, each comprising 10 trials) to assess cognitive procedural learning. We also assessed episodic and working memory, executive functions, and visuospatial abilities. ALs underwent 1.5T structural magnetic resonance imaging. RESULTS The initial cognitive phase was longer in the AL group than in the NC group, whereas the autonomous phase was shorter. In ALs, the longer cognitive phase was predicted by poorer planning and visuospatial working memory abilities, and by smaller gray matter (GM) volumes in the angular gyrus and caudate nucleus. ALs' planning abilities correlated with smaller GM volume in the angular gyrus. CONCLUSIONS Cognitive procedural learning was impaired in ALs, with a delayed transition from the cognitive to the autonomous phase. This slowdown in the automation of the cognitive procedure was related to lower planning abilities, which may have hampered the initial generation of the procedure to be learned. In agreement with this neuropsychological finding, a persistent relationship was found between learning performance and the GM volumes of the angular gyrus and caudate nucleus, which are usually regarded as markers of planning and initial learning of the cognitive procedure.
Therapeutic applications of lipoic acid: a patent review (2011 – 2014)

Introduction: Lipoic acid (LA), a naturally occurring 1,2-dithiolane analog that plays an essential role in mitochondrial bioenergetic reactions, has gained unprecedented attention as nutritional supplement and as therapeutic agent. Moreover, LA conjugates with other pharmacophores represent a promising approach toward the development of multifunctional drugs. Areas covered: The reviewed patent applications from January 2011 to April 2014 include combinations of LA with other bioactive compounds as well as LA conjugates for the treatment of a wide range of clinical conditions. Additionally, some patents disclose methods to overcome the stability problems of LA. Expert opinion: LA is currently in clinical use for the treatment of diabetic neuropathy, while small clinical trials using combinations of LA with known bioactive agents have been undertaken. The use of the LA is hampered by its instability and its rapid metabolism. Thus, formulations containing LA, in a form ensuring its stability and improving its bioavailability, can have important applications as medicines, nutritional supplements or cosmeceuticals. LA hybrids with other pharmacophores endowed with various activities, possess an enormous potential to promote human health and have been the subject of numerous publications and patent applications. Nevertheless, reliable in vivo data and clinical trials are necessary to prove these beneficial effects.
Multitask Reinforcement Learning with Quadratic Convergence

Multitask reinforcement learning (MTRL) suffers from scalability issues when the number of tasks or trajectories grows large. The main reason behind this drawback is the reliance on centeralised solutions. Recent methods exploited the connection between MTRL and general consensus to propose scalable solutions. These methods, however, suffer from two drawbacks. First, they rely on predefined objectives, and, second, exhibit linear convergence guarantees. In this paper, we improve over state-of-the-art by deriving multitask reinforcement learning from a variational inference perspective. We then propose a novel distributed solver for MTRL with quadratic convergence guarantees.
Synthesizing Time-Series with Auxiliary Classifier Generative Adversarial Networks

In recent years, deep learning has shown state-of-the-art performance on an array of problems such as speech recognition, drug discovery, image segmentation and machine translation. This success is mainly attributed to hand curated datasets either by domain experts or through crowdsourcing. However, other fields (e.g. medicine and assisted living) are lagging behind, where, data curation and sharing are limited due to several factors, for instance, privacy and expensive process of collecting labeled datasets. The motivation of this work is, therefore, to leverage Generative Adversarial Networks (GANs) to develop a framework for generating synthetic time series. This data then could be shared, use to resolve class imbalance and provide better insights into the modeling process.
Electronically Reconfigurable Dual-ModeMicrostrip Open-Loop Resonator Filter

A new type of reconfigurable asymmetric frequency response bandpass filter using dual-mode open-loop resonator is investigated. It explores the unique characteristic of the dual-mode open-loop resonator whose two operating modes, i.e., the even- and odd-modes do not couple. Thus, tuning the passband frequency is accomplished by merely changing the two modal frequencies proportionally, which makes the electronic tuning simple. Furthermore, for a single filter of this type, its selectivity can be electronically reconfigured to exhibit a higher selectivity with a finite-frequency transmission zero on either side of the passband. For the demonstration, both simulated and measured results are presented.
...OM MAN INTE SJÄLV

Byberg, L. 2002. Plasminogen Activator Inhibitor-1 and the Insulin Resistance Syndrome. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1150. 57 pp. Uppsala. ISBN 91-5545307-4. In this thesis, different aspects of the insulin resistance syndrome in relation to plasminogen activator inhibitor-1 (PAI-1) activity are investigated in a longitudinal population-based study. Participants were men investigated at ages 50 and 70 with follow-up data on mortality. High PAI-1 activity was associated with low insulin sensitivity, high concentrations of serum triglycerides, high body mass index and high waist/hip ratio, independently of each other and of potential confounders. Low birth weight predicted high blood pressure, insulin resistance, truncal obesity and high PAI1 activity but not the abdominal obesity or dyslipidaemia present in the insulin resistance syndrome. Increased physical activity level between 50 and 70 years of age, in the absence of active intervention, was associated with improved glucose, insulin, proinsulin and lipoprotein metabolism. Insulin and proinsulin seemed to be important factors that mediate much of the association between a sedentary lifestyle and increased risk of cardiovascular disease. The reported dietary intake of both monoand polyunsaturated fatty acids was positively associated with PAI-1 activity, whereas saturated fatty acid intake displayed no association. The associations present between PAI-1 activity and the fatty acid proportions in serum cholesterol esters were partly influenced by factors related with the insulin resistance syndrome. This thesis provides further knowledge to the epidemiological view of the interrelations of the insulin resistance syndrome, PAI-1, birth weight, and lifestyle factors as physical activity and dietary habits. PAI-1 is a part of the insulin resistance syndrome and is associated both with modifiable and non-modifiable factors related with this syndrome.
Position Control of an Omnidirectional Mobile Robot

Moving robots in the RoboCup Small Size League with fast reaction and low latency is crucial for the overall performance of a team. A good movement control is important to overcome the frictions of the wheels of the omnidirectional robots. Because modeling the friction is quite complex, we applied a learning algorithm based on Relative Entropy Policy Search for learning an optimal movement policy. Experiments in the simulation and with a real robot show that we are able to learn a policy that leads us to a desired target state.
Transcriptome and Genome Conservation of Alternative Splicing Events in Humans and Mice

Combining mRNA and EST data in splicing graphs with whole genome alignments, we discover alternative splicing events that are conserved in both human and mouse transcriptomes. 1,964 of 19,156 (10%) loci examined contain one or more such alternative splicing events, with 2,698 total events. These events represent a lower bound on the amount of alternative splicing in the human genome. Also, as these alternative splicing events are conserved between the human and mouse transcriptomes they should be enriched for functionally significant alternative splicing events, free from much of the noise found in the EST libraries. Further classification of these alternative splicing events reveals that 1,037 (38.4%) are due to exon skipping, 497 (18.4%) are due to alternative 3' splice sites, 214 (7.9%) are due to alternative 5' splice sites, 75 (2.8%) are due to intron retention and the other 875 (32.4%) are due to other, more complicated, alternative splicing events. In addition, genomic sequences nearby these alternative splicing events display increased sequence conservation. Both the alternatively spliced exons and the proximal intron show increased levels of genomic conservation relative to constitutively spliced exons. For exon skipping events both intron regions flanking the exon are conserved while for alternative 5' and 3' splicing events the conservation is greater near the alternative splice site.