Miracle-dz/UniFAR-FTUs huggingface dataset:
One-sensor current sharing in multiphase interleaved DC/DC converters with coupled inductors

To improve the efficiency and to reduce the volume of dc-dc converters and their filters, interleaved converters are used. For further reduction of the inductor volume, coupled inductors can be applied. In these multiphase converters, appropriate active current sharing is necessary due to the inherent current unbalance caused by the parameter deviations of the components and the duty cycles of the phases. The common method to realize current sharing is to use a single current sensor for each phase whereas the current in each phase is controlled independently. Due to the costs of the current sensors, a reduction of the quantity is desirable. In this contribution, a method is presented which allows the current sharing by means of only one current sensor without extra circuitry and computation effort. This method is analyzed exemplarily for the application in a threephase interleaved converter with coupled inductors in theory and practice. Successful operation can be stated.
Artificial intelligence. Autonomous mental development by robots and animals.

How does one create an intelligent machine? This problem has proven difficult. Over the past several decades, scientists have taken one of three approaches: In the first, which is knowledge-based, an intelligent machine in a laboratory is directly programmed to perform a given task. In a second, learning-based approach, a computer is "spoon-fed" human-edited sensory data while the machine is controlled by a task-specific learning program. Finally, by a "genetic search," robots have evolved through generations by the principle of survival of the fittest, mostly in a computer-simulated virtual world. Although notable, none of these is powerful enough to lead to machines having the complex, diverse, and highly integrated capabilities of an adult brain, such as vision, speech, and language. Nevertheless, these traditional approaches have served as the incubator for the birth and growth of a new direction for machine intelligence: autonomous mental development. As Kuhn wrote (1), "Failure of existing rules is the prelude to a search for new ones. "
Capilaridad en fluidos de partículas anisótropas

El presente trabajo se enmarca dentro de uno de los campos mas activos de la fisica actual, la fisica de la materia condensada. En particular esta dedicado al estudio de los sistemas complejos comunmente conocidos como cristales liquidos. El orden orientacional es el punto clave en estos sistemas y en este sentido se puede hablar de materia blanda con orden orientacional. Los cristales liquidos son compuestos relativamente comunes y por ello estan presentes en multitud de aplicaciones: plasticos, fibras textiles, alimentos, cosmeticos. Tambien juegan un papel relevante en aspectos biologicos como la formacion de las membranas celulares, e incluso es posible que jugaran un papel determinante en la formacion del ADN. Muchas de las aplicaciones donde podemos encontrar este tipo de sistemas involucran la interaccion del cristal liquido con superficies, siendo los dispositivos de visualizacion basados en cristales liquidos un claro ejemplo. En el desarrollo de esta tesis doctoral se abordan distintos problemas relacionados con esta cuestion desde un punto de vista microscopico, usando el funcional de la densidad como base teorica. Se busca comprender como las propiedades microscopicas de la interaccion entre el cristal liquido y la superficie afectan al comportamiento del sistema en aspectos como las propiedades de adsorcion, wetting o anchoring. Se presta especial atencion a los efectos de capilaridad, tales como el confinamiento de las fases isotropa, nematica y esmectica.
A fully integrated CMOS interface ASIC for two-axis piezoelectric angular rate MEMS inertial sensors

Microelectromechanical system (MEMS) technology has revolutionized the inertial sensors market. It enabled the development of compact, low cost, low noise and low power inertial sensors which are used in consumer, industrial and automotive applications. One of the challenges faced is in the design of interface electronics for these sensors. In this paper, we present the architecture and measurement results of a low power, low noise application specific integrated circuit (ASIC) that interfaces to two-axis consumer-grade piezoelectric angular rate MEMS inertial sensors. The proposed ASIC has been fully integrated in 0.18 μm standard HVCMOS 6-metal layer technology and achieves better performance as compared to other related work. The presented ASIC design achieves a noise floor of 5.3 m°/s/√Hz over 100 Hz bandwidth. It occupies a compact area of 4mm2 and draws 6.5mA from a single 3V supply. It meets the area, power and low-cost requirements which make it suitable for use in consumer applications such as image stabilization used in mobile phones and digital cameras.
Les patients greffés sont-ils malades ?

Notre article vise a montrer que pour certains patients greffes, la situation therapeutique est paradoxale dans la mesure ou ils sont definis comme etant non malades par les medecins. Ces patients au corps precarise, soumis a un traitement anti-rejet a vie, ne partagent pas la definition medicale de leur situation ; la figure d’un patient non malade peut elle-meme apparaitre inconcevable. Nous verrons d’abord que cette figure est soutenue par la representation mecaniste du corps, puis nous observerons ensuite le positionnement des personnes transplantees au sujet de la maladie.
IoT based Post Crash Assistance System

Road accidents are often fatal and result into major losses to families and nations. Precious lives can be saved if medical help is made available to the victims at the earliest. Several systems were proposed which provide automated accident detection and notification facility. However, majority of these systems depend on user's smartphones and applications. This paper presents an IoT based Post Crash Assistance system which used a vehicle's in-built hardware hence eliminating dependency on the smartphone. Also, the system is able to differentiate between various crash intensities and is able to respond accordingly. After exhaustive testing, it was determined that this system gives 98.33% accuracy and response time of 16.24s.
Recruitment of the Histone Methyltransferase SUV39H1 and Its Role in the Oncogenic Properties of the Leukemia-Associated PML-Retinoic Acid Receptor Fusion Protein

ABSTRACT Leukemia-associated fusion proteins establish aberrant transcriptional programs, which result in the block of hematopoietic differentiation, a prominent feature of the leukemic phenotype. The dissection of the mechanisms of deregulated transcription by leukemia fusion proteins is therefore critical for the design of tailored antileukemic strategies, aimed at reestablishing the differentiation program of leukemic cells. The acute promyelocytic leukemia (APL)-associated fusion protein PML-retinoic acid receptor (RAR) behaves as an aberrant transcriptional repressor, due to its ability to induce chromatin modifications (histone deacetylation and DNA methylation) and silencing of PML-RAR target genes. Here, we indicate that the ultimate result of PML-RAR action is to impose a heterochromatin-like structure on its target genes, thereby establishing a permanent transcriptional silencing. This effect is mediated by the previously described association of PML-RAR with chromatin-modifying enzymes (histone deacetylases and DNA methyltransferases) and by recruitment of the histone methyltransferase SUV39H1, responsible for trimethylation of lysine 9 of histone H3.
Minor displacements in the insertion site provoke major differences in the induction of antibody responses by chimeric parvovirus-like particles.

An antigen-delivery system based on hybrid virus-like particles (VLPs) formed by the self-assembly of the capsid VP2 protein of canine parvovirus (CPV) and expressing foreign peptides was investigated. In this report, we have studied the effects of inserting the poliovirus C3:B epitope in the four loops and the C terminus of the CPV VP2 on the particle structure and immunogenicity. Epitope insertions in the four loops allowed the recovery of capsids in all of the mutants. However, only insertions of the C3:B epitope in VP2 residue 225 of the loop 2 were able to elicit a significant anti-peptide antibody response, but not poliovirus-neutralizing antibodies, probably because residue 225 is located in an small depression of the surface. To fine modulate the insertion site in loop 2, a cassette-mutagenesis was carried out to insert the epitope in adjacent positions 226, 227, and 228. The epitope C3:B inserted into these positions was well recognized by the specific monoclonal antibody C3 by immunoelectron microscopy. BALB/c mice immunized with these chimeric C3:B CPV:VLPs were able to elicit an strong neutralizing antibody response (>3 log(10) units) against poliovirus type 1 (Mahoney strain). Therefore, minor displacements in the insertion place cause dramatic changes in the accessibility of the epitope and the induction of antibody responses.
Localization of the human lactate dehydrogenase B gene on the short arm of chromosome 12.

at 2Y2 years of age had demonstrated a hypoplastic right lung, absent right pulmonary artery, and a small secundum-type atrial septal defect. Her intra-venous pyelogram was normal. Roentgen examination demonstrated her bone age to be normal. She had short third, fourth, and fifth metacarpals and short second, third, and LDH assays were carried out using commercially prepared LDH assay test kits (LDH-L Stat-Pack, Calbiochem, Inc., San Diego, Calif.). The concentration of lactate in this system is 6.72 X 10-2 M, and that of NAD, 2.44 X 10-3 M. Assays were started by adding 0.2 ml of plasma to the reaction mixture and measuring the increase in optical density at 340 nm for 4 min at 220C. A unit is defined as that amount of enzyme that will catalyze the reduction of 1 ,umole of NAD per minute at 30°C.
Phamacology of fluticasone furoate and vilanterol trifenatate combination therapy for asthma

ABSTRACT Introduction: Fluticasone furoate (FF) is a novel inhaled corticosteroid (ICS). Vilanterol trifenate (VI) is a new inhaled, selective, long – acting β2 adrenergic agonist (LABA). It is now also marketed as a novel once daily combined ICS/LABA indicated for treatment of moderate and severe asthma. Areas covered: FF has a highly specific, fast association and slow dissociation from the glucocorticoid receptor, with a 24 hr duration of action. This, combined with a slow transport out of respiratory cells, creates a long tissue retention period. Vilanterol trifenate (VI) is a new inhaled, selective, long – acting β2 adrenergic agonist, also with a rapid onset of action with a maximal effect within 6 mins and prolonged lung retention with effects on lung function over 24 hours. Expert commentary: Multiple Phase I–III efficacy studies performed on FF and VI have shown an improvement in spirometry as well as symptom control in asthma. The development of once daily ICS/LABA combinations may potentially improve adherence to asthma therapy, but this has yet to be demonstrated.
Aloa : un outil de soutien social en ligne pour les aidants familiaux. (Aloa : an Application Dedicated to Online Social Support for Family Caregivers)

Chaque jour, des personnes en situation de perte d'autonomie, due a l'âge ou la maladie, beneficient de l'aide de certains de leurs proches, leurs aidants familiaux, qui les accompagnent dans des gestes simples qui ne le sont plus pour eux. Ces dernieres annees, une prise de conscience dans la societe du role et de la charge qui repose sur les aidants familiaux commence a s'imposer et pose la question de l'aide aux aidants eux-memes. Le soutien social apparait comme une reponse pertinente dans ce contexte afin d'offrir un espace d'echange et d'ecoute entre pairs traversant ou ayant traverse les memes difficultes. Le projet de recherche presente dans cette these s'inscrit dans cette problematique d'aide aux aidants familiaux en proposant d'apporter une contribution de la recherche en informatique sur ces questions complexes. Notre projet vise a proposer des services utiles et utilisables pour les aidants dans l'optique de developper une activite de soutien social en ligne. Afin de developper ces services, nous avons travaille a elaborer un cadre de conception interdisciplinaire afin de mobiliser des analyses realisees dans differentes perspectives theoriques et methodologiques de la recherche en sciences humaines et sociales. Aloa-aidants.fr est l'application issue de cette recherche et a ete developpee en cooperation le reseau de sante ReGeMA. Notre recherche porte donc sur une problematique de conception ouvrant a des questions tant sur la demarche et ses conditions de mise en œuvre que sur le produit de cette demarche.
Determination of polymerase chain reaction efficiency for diagnosis of tuberculous meningitis in Chelex-100 extracted DNA samples.

SETTING Polymerase chain reaction (PCR) offers great promise for the rapid, sensitive and specific diagnosis of tuberculous meningitis (TBM). However, the isolation of DNA of high quantity and quality from cerebrospinal fluid (CSF) samples is critical for successful PCR assays. OBJECTIVE To develop and use a single-tube method for the isolation of PCR-compatible DNA from Mycobacterium tuberculosis using Chelex-100 chelating resin, which does not require organic solvents or detergents. DESIGN The study focused on the standardisation of a suitable Chelex protocol and its evaluation in 32 CSF samples from TBM and non-TBM subjects. A simultaneous comparison was made with the conventional phenol/chloroform extraction method. RESULT PCR was found to be more sensitive, more rapid and less technically demanding with the Chelex protocol than the conventional phenol/chloroform extraction method (sensitivity 84.2% vs. 73.6%). CONCLUSION The single-tube method and the simplicity of the procedure permits early and reliable diagnosis of TBM and makes it an attractive method for routine laboratory assays.
Use and relevance of a bovine mammary gland explant model to study infection responses in bovine mammary tissue

Our aim was to develop an explant model to define more precisely the early response of bovine mammary epithelial cells to infection. Therefore we investigated the mRNA expression encoding for some soluble immunological factors in lipopolysaccharide (LPS)-treated bovine mammary gland explants. Explants were taken out from the mammary gland of eight lactating cows after slaughter then incubated with LPS (10 μg/ml) for 6 h. The mRNA expression of α-lactalbumin (α-la), various cytokines, tumour necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-8, and two immunoglobulin receptors, the neonatal Fc receptor (FcRn) and polymeric immunoglobulin receptor (pIGR), were assessed with qPCR before and after 3 h and 6 h of LPS challenge. Both immunoglobulin receptors and α-la increased at 3 h then recovered their initial level at 6 h whereas IL-1β, IL-6 and IL-8 increased only after 6 h (P<0·05). Surprisingly, TNF-α transcripts did not show any regulation in response to the LPS treatment. We nevertheless concluded that our model was valid to examine the short-term response of mammary epithelial cell challenged with LPS.
LAN gateway designs for multicast communication

The author considers a number of issues regarding gateway design for multicast communication in local area networks. Initially, two designs were considered: (1) explicit identification, in which the source explicitly transmits a message to the gateway, in addition to those already transmitted to the local network; and (2) implicit identification, in which the gateway is promiscuous and receives all multicast messages sent on the local network. It was found that many of the problems associated with explicit identification and implicit identification when used individually could be eliminated by using a hybrid gateway which allowed an explicitly identified parent gateway process to spawn a child gateway which acted as an optimized implicitly identified gateway. The merit of the hybrid gateway is that it allows the source to determine whether the message should be sent to remote networks (an explicitly identified gateway feature), but the actual message transmission is performed by implicitly identifying the gateway. <<ETX>>
Allozyme variation among six populations of the freshwater-snail Oncomelania hupensis in Zhejiang, China.

Thirteen enzymes encoded by 16 loci of six population of Oncomelania hupensis in Zhejiang, China, were investigated by means of starch gel electrophoresis. Ten loci (AO, 6PGD, ME, AKP, OCT-1, HBDH-1, HBDH-2, XDH, MDH and MPI) were monomorphic and 6 loci (OCT-2, PGI, AAT, PGM-1, PGM-2 and ACP) were polymorphic. Three enzymes (OCT, HBDH and PGM) were encoded by 2 loci. The results indicated that there were allozyme variations in two subspecies, O.h. hupensis and O.h. fausti in Zhejiang, China. Nei's multilocus genetic distances (D) between subspecies ranged from 0.167 to 0.265. Minor genetic distances were detected between populations of the same subspecies. The results indicated that the enzyme acid phosphatase (ACP) is a possible marker to measure the degree of susceptibility of O. hupensis to S. Japonicum.
Monolithic micro gas chromatographic separation column and detector

We present the design, fabrication, and operation of the first monolithic gas chromatography (GC) separation column and detector. The monolithic integration of a high sensitivity detector with a separation column has many potential advantages over the discrete components of a traditional chromatography system. In high-speed GC systems, component interconnections can cause crucial errors which increase with the square of analysis speed causing critical loss of resolution. A monolithically integrated device would eliminate the requirement for helium-tight interconnections, which are bulky and labor intensive. Additionally, batch fabrication of integrated devices would eliminate the requirement for a separate, expensive, and fragile detector, which decreases the cost of micro GC systems through economies of scale.
The two faces of the Escherichia coli 23 S rRNA sarcin/ricin domain: the structure at 1.11 A resolution.

The sarcin/ricin domain of 23 S - 28 S ribosomal RNA is essential for protein synthesis because it forms a critical part of the binding site for elongation factors. A crystal structure of an RNA of 27 nucleotides that mimics the domain in Escherichia coli 23 S rRNA was determined at 1.11 A resolution. The domain folds into a hairpin distorted by four non-canonical base-pairs and one base triple. The fold is stabilized by cross-strand and intra-stand stacking; no intramolecular stabilizing metal ions are observed. This is the first structure to reveal in great detail the geometry and the hydration of two common motifs that are conserved in this rRNA domain, a GAGA tetraloop and a G-bulged cross-strand A stack. Differences in the region connecting these motifs to the stem in the E. coli and in the rat sarcin/ricin domains may contribute to the species-specific binding of elongation factors. Correlation of nucleotide protection data with the structure indicates that the domain has two surfaces. One surface is accessible, lies primarily in the major groove, and is likely to bind the elongation factors. The second lies primarily in the minor groove, and is likely to be buried in the ribosome. This minor groove surface includes the Watson-Crick faces of the cytosine bases in the unusual A2654.C2666 and U2653.C2667 water-mediated base-pairs.
Meta-Analysis Comparing Pain Reduction Following Vertebroplasty and Conservative Treatment for Osteoporotic Vertebral Compression Fractures : A Meta-Analysis of Randomized Controlled Trials

osteoporotic fractures. Pain is the main symptom. Percutaneous vertebroplasty (PVP) is a therapeutic procedure performed to reduce pain in vertebral compression fractures. Numerous case series and several small, non-blinded, non-randomized controlled studies have suggested that vertebroplasty is an effective means of relieving pain from osteoporotic fractures. However, a recent pooled analysis from 2 multicenter randomized controlled trials concluded that the improvement in pain afforded by PVP was similar to placebo.
PHENOTYPICAL IDENTIFICATION OF ATYPICAL STAPHYLOCOCCUS AUREUS STRAINS ISOLATED FROM MILK OF COWS FROM ONE HERD

The aim of the study was to characterise the free coagulase-negative Staphylococcus sp. strains isolated from normal (9.4%) and inflamed quarter milk samples of dairy cows in one herd localised in southern Poland. The isolates were examined phenotypically by cultural features, tube coagulase test, clumping factor (CF), and commercial agglutination test. Total number of 427 strains were cultivated on different media: Congo red agar, DNase medium, mannitol salt agar, and crystal violet agar. About 25% of the strains were examined by the disc diffusion method for their sensitivity to chosen antibiotics. All of the analysed strains showed α, β, α+β, or lh type of haemolysis on plate with 5% sheep blood agar, and had positive reaction in CF and agglutination tests, but were negative in tube coagulase test. These strains showed DNase activity and ability to mannitol fermentation; however, none of the strains produced slime. There were variations in growth on crystal violet agar: examined strains belonged to three types of growth (A, E, and C). The strains were highly susceptible in vitro to oxacillin (99.2%), cefoperazone (95.2%), and amoxicillin with clavulanic acid (93.6%), and highly resistant to neomycin (27.2%), tetracycline (21.6%), and streptomycin (20.8%). In conclusion, it can be stated that intramammary infections in cows can be caused by atypical free coagulase-negative strains of Staphylococcus aureus.
Optimizing Social Welfare for Task Offloading in Mobile Edge Computing

While mobile applications are increasing in use and complexity, the computational constraints on mobile devices remain as the bottleneck for serving computation-intensive mobile applications. Mobile edge computing (MEC) provides a computing paradigm to serve the computational demands of such mobile applications by offloading the mobile devices’ computational tasks to the edge servers. Double auction has been adopted in MEC to provide a mechanism to assign the tasks of mobile devices to the edge servers while considering the satisfaction level for both entities. We improve the double auction mechanism beyond prior research in MEC. Specifically, we construct a model to support the real-world practices in the pricing scheme of edge computing, such as that provided by Amazon, and to support the parallelizing and distributing of workloads to multiple edge servers. We propose an efficient mechanism to achieve the optimal social welfare by converting the allocation problem to a minimum cost flow problem. In addition to reaching the optimal social welfare in polynomial time computations, our proposed mechanism achieves individual rationality and strong balance budget.