Miracle-dz/UniFAR-FTUs huggingface dataset:
Will Oral Contraceptives Join SSRIs as a First-Line Treatment Option for Women with Premenstrual Dysphoric Disorder?

10.2217/17455057.2. 2.183 © 2 ‘It is assumed that ovulationrelated mechanisms trigger premenstrual symptoms in women with a vulnerability to CNS dysregulation. Several studies have identified abnormal serotonergic parameters during the entire menstrual cycle and the luteal phase in women with premenstrual dysphoric disorder. ‘ s p t t h t D h a r T t s c Premenstrual dysphoric disorder (PMDD) is a combination of emotional, behavioral and physical symptoms that occur in the luteal phase of the menstrual cycle, abate shortly after the onset of menses, and cause impairment in social and role functioning [1]. The hallmark emotional symptoms of PMDD include irritability, anxiety or tension, mood swings and depressed mood. PMDD occurs in approximately 5% of menstruating women and is considered the severe end of the spectrum of clinically significant premenstrual symptoms. Reduced quality of life (QoL), increased healthcare costs and reduced productivity at work have been documented in women with PMDD [2,3]. Recent reviews and expert guidelines summarize the diagnostic criteria, recommended forms for the prospective daily charting of symptoms and the importance of identifying a premenstrual exacerbation of an underlying mood or medical illness prior to the initiation of treatment [4–7]. The etiology of PMDD is likely to be multifactorial, and many possible etiological factors have been reviewed [8]. It is assumed that ovulation-related mechanisms trigger premenstrual symptoms in women with a vulnerability to CNS dysregulation [9]. Several studies have identified abnormal serotonergic parameters during the entire menstrual cycle and the luteal phase in women with PMDD [8]. Studies also suggest an abnormal response to allopregnanolone and other γ-aminobutyric acid (GABA)-ergic agonists during the luteal phase of the cycle [10]. The
Representing stereo data with the Delaunay triangulation

A coherent way of interpolating 3-D data obtained by stereo, for example, with a simplicial polyhedral surface is discussed. The method is based on constrained Delaunay triangulation; the polyhedral surface is obtained by using a simple visibility property to mark tetrahedra likely to be empty. The method is intrinsically discontinuity-preserving and yields both a surface representation of objects and a volume representation of free space which may be useful in robotics. Algorithms to implement the method are described and their complexity analyzed in the worst case and average case situations where tools of probabilistic geometry are used. <<ETX>>
The Effect of Customers’ Trust on E-Commerce: A Survey of Indonesian Customer B to C Transactions

This study aims at analyzing the effect of vendor’s ability, benevolence, and integrity toward e-Commerce customers’ trust. This study makes use of Indonesian e-Commerce users as research samples while using Likert scale questionnaire for data collection. Furthermore, the questionnaires are sent to as many as 198 respondents through the mailing list. For data analysis method this research uses Structural Equation Model (SEM). Out of three predictor variables (ability, benevolence, and integrity), it is only vendor’s integrity that has positive and significant effect on Indonesian customers’ trust.
Real-Time Implementation of Model Predictive Neural Controller for Heat Exchanger

The control of heat exchanger is complex due to its nonlinear dynamics, and particularly the variable steady-state gain and time constant with the process fluid. Linear controllers designed based on linear models will be effective only in a small region around the operating point. The artificial neural network (ANN) technique is used to control the temperature of hot fluid flowing in the inner tube of a physical heat exchanger setup. A methodology is proposed for training and prediction of dynamic behaviour of heat exchanger using feed-forward neural network with external recurrent connections. Then a nonlinear predictive control strategy based on identified model is proposed for heat exchanger control. The performances of neural controller are evaluated in real time and results are compared with a localized PID controller.
Cardiac troponin T vs other biochemical markers in patients with congestive heart failure.

BACKGROUND Several pathologic processes can cause myocardial injury, which is followed by cardiac remodeling and congestive heart failure (CHF). Cardiac troponin T (cTnT), a specific and sensitive marker of myocardial injury, has been related to long-term outcome in patients with CHF, so the relationship between cTnT and other biochemical markers associated with the pathophysiology of CHF was investigated in the present study. METHODS AND RESULTS Between February 2004 and December 2005, 145 consecutive hospitalized patients (mean left ventricular ejection fraction (LVEF) 31.6+/-0.9%) with CHF were divided into low (<0.01 ng/ml) and high (> or =0.01 ng/ml) serum cTnT groups. Correlations with other prognostic biochemical markers, including brain natriuretic peptide (BNP), type I collagen C-terminal telopeptide (ICTP), procollagen type III peptide (PIIIP), renin, norepinephrine (NOREPI), C-reactive protein (CRP), cholesterol, hemoglobin (Hb), uric acid and HbA1c were examined. cTnT was high in 46 (32%) and low in 99 (68%) patients at baseline. Patients with high cTnT had abnormally high blood concentrations of BNP (p<0.0001), ICTP (p<0.0001), PIIIP (p=0.0006), NOREPI (p=0.0119), CRP (p=0.0003), uric acid (p=0.0026) and HbA1c (p=0.0361). In contrast, concentrations of cholesterol and Hb were significantly lower in patients with high cTnT (p=0.0319 and 0.0005, respectively). Death from or rehospitalization for CHF occurred in 41% in the high vs 9% in the low cTnT group (p=0.0002). Univariate analysis showed that high cTnT (p=0.0005), BNP (p=0.0001), renin (p=0.0158), NOREPI (p=0.0094), old age (p=0.0390), low LVEF (p=0.0231) and high New York Heart Association (NYHA) class (p=0.0006) were predictors of death from or rehospitalization for CHF. By multivariate analysis including BNP, NOREPI, age, LVEF and NYHA class, high cTnT and renin remained as significant predictors. CONCLUSIONS Patients with ongoing myocardial injury and high cTnT had associated findings consistent with activation of the sympathetic system, synthesis of cardiac fibrosis, inflammation and metabolic abnormalities. By multivariate analysis, high cTnT and renin remained significant predictors of death or rehospitalization.
Predictive adaptive method for synchronous rectification

This paper proposes an innovative algorithm for synchronous rectification in LLC power converters. The algorithm optimizes the turn off instant of the rectifier MOSFETS by sensing the drain to source voltage detecting the body diode conduction and minimizing it. An overview of this method will be described in comparison to analog solutions. The algorithm, the equations, the digital implementation will be detailed. The comparison in terms of efficiency and component number will be shown with physical measurements based on a real implementation. The measures will confirm the analysis and the performance reached. Moreover the benefits of the method will show up.
There is no motor redundancy in human movements. There is motor abundance.

It is suggested that the famous problem of motor redundancy is inapplicable to human voluntary movements. Such notions as “the elimination of biomechanical degrees of freedom” should not be used in human movement studies. During natural movements, elements within apparently redundant sets are all involved in solving motor tasks. The abundance of elements is a keystone forming the foundation of motor synergies. It allows natural movements to display both flexibility and stability.
Adoption of internet banking services in China: is it all about trust?

Purpose – Numerous empirical studies on internet banking services (IBS) adoption have focused either on perceived risk or trust; but rarely have they combined these concepts and used empirical evidence to investigate the relationship. This study aims to contribute to this field by looking simultaneously at the roles of trust and perceived risk on consumers' IBS usage intention.Design/methodology/approach – An integrated model explaining the interrelationships between trust, perceived risk and usage intention is developed. The research was conducted on a sample of 432 young Chinese consumers who can be classified as IBS early adopters. The quantitative findings are enhanced by the analysis of extensive qualitative data providing unique insights into this market.Findings – Results indicate that there is a significant relationship between trust and perceived risk and that both are crucial in explaining the internet banking usage intention. Furthermore, trust in the bank is fundamental not only to reducing ri.
The local ‘war for talent’ – recruitment of recent tertiary education graduates from a regional perspective: some evidence from the German case

We analyse recruitment of recent tertiary education graduates drawing on a rich set of interviews with human resource managers of 46 large- and medium-sized firms in different regions across Germany. Specifically, we address the question of which higher education institutions' managers choose for campus recruiting and which criteria managers use to select recruitment institutions. We find that a substantial share of institutions is located close to the firm seeking to recruit and that the major criterion for selection is geographic proximity to campus. Notably, quality- and performance-related criteria are hardly mentioned. This result is robust for firms in different regional settings, of different size and popularity. We further elaborate on the reasons behind this finding and conclude that the firms' regional orientation is driven by the interplay between three major factors: enhancing recruitment success and retention probability of graduates, avoiding competition with other employers and dealing with imperfect information.
Waiting for radiotherapy: Financing increased capacity is a must

Editor—Dodwell and Crellin's points about the issues facing radiotherapy services are starting to apply to the services that administer chemotherapy and other parenteral drug treatments for cancer.1 The number of patients requiring such treatments for cancer is rising, as the baby boom generation ages and as technology changes; the recently reported …
Haemodynamic responses to a ring-deleted analogue of atrial natriuretic peptide in rats with cirrhosis.

AIMS In cirrhosis, the effects of selective activation of atrial natriuretic peptide (ANP) R2-receptors on haemodynamics, endogenous ANP (ANP1-28) and sodium excretion are unknown. The aim of the present study was to examine the effects of selective activation of ANP-R2 receptors by ANP4-23 (a ring-deleted analogue of endogenous ANP) on haemodynamics, plasma ANP1-28 concentrations and urinary sodium excretion in conscious cirrhotic and normal rats. METHODS Haemodynamics and sodium excretion were measured prior to and following administration of ANP4 23. Plasma ANP1-28 concentrations were also measured. RESULTS In cirrhotic rats, ANP4-23 significantly decreased portal pressure and tributary blood flow by 15% and 25% respectively but significantly increased portal territory vascular resistance by 30%. Systemic and renal haemodynamics were not altered by ANP4-23. In normal rats, ANP4-23 did not significantly change splanchnic, renal and systemic haemodynamics. In both groups of rats, ANP4-23 increased plasma ANP1-28 concentrations but did not change sodium excretion. CONCLUSIONS ANP4-23 administration induced splanchnic vasoconstriction in cirrhotic but not in normal rats. ANP4-23-elicited vasoconstriction caused a portal hypotensive effect in cirrhotic rats. Finally, in both groups, ANP4-23 caused an increase in plasma ANP1-28 concentrations but did not increase sodium excretion.
Termination of the drug career: AN INTERVIEW STUDY OF 58 EX‐ADDICTS

Fifty‐eight ex‐addicts, representing 87 % of a group found to be drug‐free at an earlier 3‐year follow‐up, have been the target group of an interview study, which aimed at elucidating various phases of the drug career. It was found that drug abusers tend to break their drug‐taking habits either early (before 2 years of abuse) or late (after 6 years or more). Those who abandoned the drug career early regarded giving up drugs as easy and had often been supported by relatives and drug‐free friends. Their dominating reason for giving up drugs was adverse drug reactions, or infectious complications. Those who abandoned the career late reported that it had been a difficult process and that they had received little or no support from friends and relatives. To a large extent they had resorted to the aid of outpatient clinics. This group of ex‐addicts gave as their most common reason for giving up drugs: they had grown tired of the life of a street addict. The considerable number of critics of psychiatric inpatient treatment (74 % rated inpatient clinics as moderately important or unimportant) casts doubt on present treatment approaches.
Organisational ambidexterity and supply chain agility: the mediating role of external knowledge sharing and moderating role of competitive intelligence

ABSTRACT The dynamic growth of a supply chain in an incessantly changing environment emanates from the dynamics of an organisation as well as its supply chain members. The primary aim of this research is to investigate the relationships between supply chain agility and its dynamic precursors including organisational ambidexterity and external knowledge sharing. The research further examines the moderating role of competitive intelligence for the relationship between organisational ambidexterity and supply chain agility. A sample of 381 respondents from chemical manufacturing companies in Vietnam produced the data for analysis. The research results shed light on the chain effect from organisational ambidexterity through external knowledge sharing to supply chain agility. The moderating role that CI plays in the relationship between organisational ambidexterity and supply chain agility was also verified. The findings from the research broaden supply chain literature through establishing the positive effect of organisational ambidexterity on supply chain agility with CI as a moderator for this effect.
Provision of Inertial and Primary Frequency Control Services Using Offshore Multiterminal HVDC Networks

This paper addresses the problem of providing frequency control services, including inertia emulation and primary frequency control, from offshore wind farms connected through a multiterminal HVDC network. The proposed strategy consists of a cascading control mechanism based on dc voltage regulation at the onshore converters and frequency regulation at the offshore converters. The control scheme involves only local measurements and actions avoiding security and reliability issues of control structures based on remote information. The effectiveness of the proposed strategy is illustrated in a test system that consists of two nonsynchronous areas linked by a multiterminal HVDC grid where two offshore wind farms are also connected.
Optimization of symptom observation matrix in vibration condition monitoring

In diagnostics of complex machines, for their condition assessment we often use many ‘would be’ symptoms at the beginning, especially at the diagnostic startup of a new machine. The discrete observation of this ‘would be’ symptom vector creates so called symptom observation matrix (SOM). Using next the singular value decomposition (SVD) for the given SOM, one can extract the generalized fault symptoms, describing the fault evolution in a given case, and also diagnostic contribution of measured symptoms. Using the symptom reliability concepts further, and the grey system forecast methodology, it is possible to asses the generalized symptoms limit value. In this way one can establish the needed dimensionality of symptom observation matrix, and moreover assess the residual system life. However, doing this we have to establish new criteria for the dimensionality of SOM, based not on the number of symptoms in use, but the quality of diagnostic decision. This concept was verified in the paper using the data taken from real cases of vibration condition monitoring practice.
Evaluation of Perceived Organizational Justice Personnel and Its Relationship to Effective Implementation of the Organization's Strategy and Commitment among the Staff in Tehran Stock Exchange

One of the indicators of an organization's goal is having committed human resources. Organizational commitment factors are invisible but important transition can affect on the behavior of the employees in particular organizational behavior, which has attracted a lot of attention. The cornerstone of the strategy of creating a strong organization is using appropriate level in the organization to understand the cause of justice in the organization's staff implementation, especially in the area of human resources which is regarded as the most important part in the process. In this context, the present study was to evaluate the employees' perceived organizational justice and its relation to the effective implementation of the strategy and the commitment of staff in Tehran Stock Exchange, which deals. To achieve this goal, data were collected through questionnaires, distributed among 186 employees of the organization and Pearson's correlation coefficient was used for data analysis and regression analysis. The results showed a significant relationship between perceived organizational justice and effective enforcement strategy and organizational commitment there. In other words, establishing justice, effective implementation of the strategy and the organizational commitment of staff can play a significant role in raising efficiency among the employees.
Vascular endothelin-1 gene expression and effect on blood pressure of chronic ETA endothelin receptor antagonism after nitric oxide synthase inhibition with L-NAME in normal rats.

BACKGROUND Vascular expression of the endothelin-1 gene may be associated with severe vascular hypertrophy. Because in rats, inhibition of NO synthase with the L-arginine analogue N omega-nitro-L-arginine methyl ester (L-NAME) induces blood pressure elevation associated with little cardiovascular hypertrophy, we studied vascular endothelin-1 gene expression in L-NAME-treated rats and the effects of chronic endothelin antagonism. METHODS AND RESULTS Sprague-Dawley rats received 100 mg.kg-1.d-1 L-NAME in their drinking water for 3 weeks. Systolic blood pressure rose to 189 +/- 3 mm Hg (P < .001 versus control rats). By Northern blot analysis, endothelin-1 mRNA levels were similar in aortas and mesenteric arteries of control and L-NAME-treated rats. The blood pressure of L-NAME hypertensive rats treated with the ETA-selective endothelin receptor antagonist A-127722 for 3 weeks at a low dose (10 mg.kg-1.d-1) and a high dose (30 mg.kg-1.d-1) was not different from that of rats receiving L-NAME but not the endothelin antagonist. Treatment with the ACE inhibitor cilazapril lowered the blood pressure of L-NAME-treated rats equally whether or not they were receiving the ETA antagonist. CONCLUSIONS These results indicate that the endothelin system does not participate to an important degree in the mechanisms leading to elevated blood pressure after chronic NO synthase inhibition with L-NAME in normal rats. In the chronic model of L-NAME-induced hypertension, blockade of the renin-angiotensin system does not unmask an endothelin-dependent vasopressor tone. In addition, either NO does not regulate vascular endothelin-1 gene expression or L-NAME exerts an inhibitory effect on endothelin expression in blood vessels.
Service quality, trust, commitment and service differentiation in business relationships

Purpose – While service quality, trust and commitment are frequently cited as critical to achieving important firm outcomes, the role of service differentiation in this framework is largely unknown. Yet, differentiation is important because a firm's distinctiveness is linked to client‐perceived value, competitive advantage, and a target market focus. Thus, the purpose of this study is to examine the role of service differentiation in business‐to‐business relationships.Design/methodology/approach – Hypotheses were tested using a sample of business clients from a large European financial services firm. The senior primary contact in each client firm was contacted by phone/e‐mail to arrange for completion of the survey. Using the survey instrument, respondents provided information on their relationship with the provider organization.Findings – Results indicated that service quality had an impact on trust, differentiation and relationship outcomes. Trust was found to drive service differentiation. Differentiat.
Cryptococcal Interactions with the Host Immune System

ABSTRACT Opportunistic pathogens have become of increasing medical importance over the last decade due to the AIDS pandemic. Not only is cryptococcosis the fourth-most-common fatal infectious disease in sub-Saharan Africa, but also Cryptococcus is an emerging pathogen of immunocompetent individuals. The interaction between Cryptococcus and the host's immune system is a major determinant for the outcome of disease. Despite initial infection in early childhood with Cryptococcus neoformans and frequent exposure to C. neoformans within the environment, immunocompetent individuals are generally able to contain the fungus or maintain the yeast in a latent state. However, immune deficiencies lead to disseminating infections that are uniformly fatal without rapid clinical intervention. This review will discuss the innate and adaptive immune responses to Cryptococcus and cryptococcal strategies to evade the host's defense mechanisms. It will also address the importance of these strategies in pathogenesis and the potential of immunotherapy in cryptococcosis treatment.
Consensus development conference on antipsychotic drugs and obesity and diabetes.

Antipsychotic medications are an important component in the medical management of many psychotic conditions. With the introduction of the second-generation antipsychotics (SGAs) over the last decade, the use of these medications has soared. Although the SGAs have many notable benefits compared with their earlier counterparts, their use has been associated with reports of dramatic weight gain, diabetes (even acute metabolic decompensation, e.g., diabetic ketoacidosis [DKA]), and an atherogenic lipid profile (increased LDL cholesterol and triglyceride levels and decreased HDL cholesterol). Because of the close associations between obesity, diabetes, and dyslipidemia and cardiovascular disease (CVD), there is heightened interest in the relationship between the SGAs and the development of these major CVD risk factors. To gain a better understanding of this relationship, the American Diabetes Association, the American Psychiatric Association, the American Association of Clinical Endocrinologists, and the North American Association for the Study of Obesity convened a consensus development conference 19–21 November 2003 on the subject of antipsychotic drugs and diabetes. An eight-member panel heard presentations from 14 experts drawn from the areas of psychiatry, obesity, and diabetes. Presentations were also made by a representative from the U.S. Food and Drug Administration (FDA) and by representatives from the AstraZeneca, Bristol-Myers Squibb, Janssen, Lilly, and Pfizer pharmaceutical companies. In addition, before the conference, the consensus panel was given copies of most of the known peerreviewed, English language clinical studies published in this area, as well as additional articles from animal studies; other papers and abstracts were reviewed at the conference. With this information, the panel developed a consensus position on the following questions: