Miracle-dz/UniFAR-FTUs huggingface dataset:
Motor vehicle accident is a risk factor for traumatic head injury among children in Abuja: analysis of the first trauma registry in Nigeria

Introduction Pediatric traumatic injury is a major public health concern that is poorly documented in lower and middle-income countries. This study analyzed data on pediatric injuries from a unique hospital trauma registry in Abuja, Nigeria. Methods Data were analyzed on 220 traumatically injured patients aged 21 years/less to describe injury characteristics and to determine the association between mechanism of injury and pediatric head injuries in Abuja, Nigeria, between 2014 and 2015. Bivariate analysis using Pearson's chi-square and adjusted logistic regression were conducted to characterize the population and identify risk factors for head injury. P-values<0.05 were considered statistically significant. All statistical analyses were performed using STATA v.15. 1. Results The majority of patients were male (60.9%) with a mean age (SD) of 12.5±6.9 years. Head injuries were most common (49.6%), followed by chest (14.1%), abdomen (12.3%) and back (7.7%). The mechanism of injury was statistically significantly associated with head injury (p=0.027) with 63% of children in a motor vehicle accident sustaining a head injury. After adjusting for covariates, the odds of head injury were 3.8 times higher for children injured in a motor vehicle accidents (MVA) compared to those with falls (95%CI 1.40-10.40). Conclusion This analysis reveals that motor vehicle accident is a risk factor for traumatic head injury among children in Nigeria. Therefore, efforts should be made to address motor vehicle accidents involving children. These data will help to inform age-related prevention and treatment strategies. The results of this study highlight the importance of collecting pediatric trauma data in developing countries.
Pregnant and the Postpartum Women’s Knowledge and Awareness of Venous Thromboembolism

Background: The incidence of Venous thromboembolism (VTE) in pregnant women is 4-5 times higher than that in non-pregnant women, and the risk is increased postpartum. There are limited studies that assess the awareness of VTE among at-risk pregnant and postpartum women. Methods: A quantitative cross-sectional study including a validated survey was administered to pregnant women in the outpatient clinic and those hospitalized for labor at King Abdulaziz Medical City (KAMC) in Riyadh, Saudi Arabia. Results: Out of 340 participants, 57% correctly described the cause of deep vein thrombosis (DVT). Only 26.8% and 13.8% reported awareness of DVT and Pulmonary embolism (PE) respectively. About 32% of the participants who had previous knowledge about DVT, knew that swelling of the leg is one of its major symptoms, and only 25% recognized the shortness of breath as a major symptom of PE. Long periods of inactivity or undergoing surgery were correctly identified as key risk factors for developing a blood clot by only 20%, and 14.4% of the participants respectively, while 7.5% were aware that pregnancy or postpartum are risk factors for VTE. Though most participants (99.7%) agreed that blood clots can cause death, 90.3% believed that blood clots cannot be prevented. The educational level has a significant effect on participants’ awareness of DVT. Conclusion: This study demonstrates knowledge deficit and lack of awareness of VTE among pregnant and postpartum patients. More effort must be provided to increase the awareness of VTE risk to ensure safe and high-quality patient care.
Source-to-Source Compilation via Submodules

Racket's macro system enables language extension and definition primarily for programs that are run on the Racket virtual machine, but macro facilities are also useful for implementing languages and compilers that target different platforms. Even when the core of a new language differs significantly from Racket's core, macros offer a maintainable approach to implementing a larger language by desugaring into the core. Users of the language gain the benefits of Racket's programming environment, its build management, and even its macro support (if macros are exposed to programmers of the new language), while Racket's syntax objects and submodules provide convenient mechanisms for recording and extracting program information for use by an external compiler. We illustrate this technique with Magnolisp, a programming language that runs within Racket for testing purposes, but that compiles to C++ (with no dependency on Racket) for deployment.
Not Only Mutations Matter: Molecular Picture of Acute Myeloid Leukemia Emerging from Transcriptome Studies

The last two decades of genome-scale research revealed a complex molecular picture of acute myeloid leukemia (AML). On the one hand, a number of mutations were discovered and associated with AML diagnosis and prognosis; some of them were introduced into diagnostic tests. On the other hand, transcriptome studies, which preceded AML exome and genome sequencing, remained poorly translated into clinics. Nevertheless, gene expression studies significantly contributed to the elucidation of AML pathogenesis and indicated potential therapeutic directions. The power of transcriptomic approach lies in its comprehensiveness; we can observe how genome manifests its function in a particular type of cells and follow many genes in one test. Moreover, gene expression measurement can be combined with mutation detection, as high-impact mutations are often present in transcripts. This review sums up 20 years of transcriptome research devoted to AML. Gene expression profiling (GEP) revealed signatures distinctive for selected AML subtypes and uncovered the additional within-subtype heterogeneity. The results were particularly valuable in the case of AML with normal karyotype which concerns up to 50% of AML cases. With the use of GEP, new classes of the disease were identified and prognostic predictors were proposed. A plenty of genes were detected as overexpressed in AML when compared to healthy control, including KIT, BAALC, ERG, MN1, CDX2, WT1, PRAME, and HOX genes. High expression of these genes constitutes usually an unfavorable prognostic factor. Upregulation of FLT3 and NPM1 genes, independent on their mutation status, was also reported in AML and correlated with poor outcome. However, transcriptome is not limited to the protein-coding genes; other types of RNA molecules exist in a cell and regulate genome function. It was shown that microRNA (miRNA) profiles differentiated AML groups and predicted outcome not worse than protein-coding gene profiles. For example, upregulation of miR-10a, miR-10b, and miR-196b and downregulation of miR-192 were found as typical of AML with NPM1 mutation whereas overexpression of miR-155 was associated with FLT3-internal tandem duplication (FLT3-ITD). Development of high-throughput technologies and microarray replacement by next generation sequencing (RNA-seq) enabled uncovering a real variety of leukemic cell transcriptomes, reflected by gene fusions, chimeric RNAs, alternatively spliced transcripts, miRNAs, piRNAs, long noncoding RNAs (lncRNAs), and their special type, circular RNAs. Many of them can be considered as AML biomarkers and potential therapeutic targets. The relations between particular RNA puzzles and other components of leukemic cells and their microenvironment, such as exosomes, are now under investigation. Hopefully, the results of this research will shed the light on these aspects of AML pathogenesis which are still not completely understood.
The Evaluation of Motivational Interviews Influence for the Medication Adherence of Chronic Disease - A Systematic Review

: Chronic disease is a prolonged illness and rarely heals. Although not all chronic diseases are life-threatening, it will create an economic burden for individuals, families, and society as a whole. Long-term care and rehabilitation is needed in chronic diseases, therefore awareness to adhere the medication is necessary to maintain the condition and improve the health status of patients with chronic diseases. Motivational Interviewing (MI) is one form of cognitive therapy in the form of individual-focused counseling techniques designed to help individuals explore and overcome ambivalence in changing their behavior. The objective of this study is to conduct a systematic review of recent studies using randomized controlled trials, the effect of motivational interviews on medication adherence in patients with chronic disease. The reviewed articles that were identified through database searches: Sage, Pro Quest, Springer links, Science Direct, and Ebso Host. The year search limit used was 7 years (2010 -2017). The search results obtained 8 articles that met the criteria. This systematic review generally recommends psychological interventions: motivational interviews in improving medication adherence in patients with chronic disease. However, further research needs to be done by using RCTs that focus on one chronic disease so that the effectiveness of the intervention is known. This is due to a variety of factors that can promote medication adherence to any disease, especially chronic disease.
Offline signature verification using convolution Siamese network

This paper presents an offline signature verification approach using convolutional Siamese neural network. Unlike the existing methods which consider feature extraction and metric learning as two independent stages, we adopt a deepleaning based framework which combines the two stages together and can be trained end-to-end. The experimental results on two offline public databases (GPDSsynthetic and CEDAR) demonstrate the superiority of our method on the offline signature verification problem.
The Role of Immunohistochemistry Studies in Distinguishing Malignant Mesothelioma from Metastatic Lung Carcinoma in Malignant Pleural Effusion

Background and Objective: Early diagnosis of malignant pleural mesothelioma (MPM) is the key point of its treatment. The main problem is the precise diagnosis of mesothelioma and its differentiation from metastatic lung adenocarcinoma. Mesothelioma exhibits complex immunohistochemical characteristics. The aim of this study was to study hybrid immunohistochemistry in the differential diagnosis of primary malignant pleural effusion from metastatic pulmonary cancers. Material and Methods: Twenty tissue samples in paraffin blocks from the pathology department of Imam Reza Hospital in Tabriz whose pathology reports cited mesothelioma or metastatic lung adenocarcinomas, were included in the studies. These tissues were deemed appropriate for IHC in terms of tissue quality and quantity. They were studied and evaluated for pathological markers. Results: In patients with adenocarcinoma CK7 in 100% of patients (13 patients), TTF1 in 61.5% of patients (8 patients) and CEA in 53.8% of patients (7 patients) were positive, but HBME1 and Calretinin were negative for all patients. In patients with mesothelioma, HBME1 and Calretinin were positive in 100% of patients (7 patients) and TTF1, CEA and CK7 were negative. Conclusion: The results of this study showed that CEA, CK7, TTF1, Calretinin and HBME1 are suitable criteria for differentiating between metastatic lung adenocarcinoma and mesothelioma, and can differentiate the mesothelioma and adenocarcinoma with high accuracy.
An Unusual Cutaneous Presentation of Mycobacterium Tuberculosis Infection in a Renal Transplant Recipient

Department of Microbiology, Chettinad Hospital & Research Institute , Chettinad Academy of Research & Education, Kelambakkam, Chennai, Tamilnadu, India *Corresponding Author Dr Priyadarshini Shanmugam Professor & Head, Department of Microbiology, Chettinad Hospital & Research Institute Abstract A 30-year-old male, who had undergone renal transplantation from a deceased donor on august 2017 with a stable graft function, presented with the complaints of fever and an ulcer on the right foot. On examination, the patient was malnourished and febrile, on inspection the ulcer was irregular approximately 3 x 2.5 x 3 cm in size, situated on the lateral aspect of dorsum of the right foot with yellowish white discharge, creamy in consistency. Pus for culture and sensitivity revealed the growth of Enterobacter spp which was sensitive to almost all the antibiotics used for Gram negative bacilli. Ziehl-Neelsen method of staining by using 25 % sulfuric acid as a decoloriser showed the presence of acid-fast bacilli in all smears. The pus sample was sent for Cartridge Based Nucleic Acid Amplification (Gene Xpert) test which was positive for Mycobacterium tuberculosis with negative rifampicin resistance.
Nitric Oxide, Iron and Neurodegeneration

Iron is a crucial cofactor for several physiological functions in the brain including transport of oxygen, DNA synthesis, mitochondrial respiration, synthesis of myelin, and neurotransmitter metabolism. If iron concentration exceeds the capacity of cellular sequestration, excessive labile iron will be harmful by generating oxidative stress that leads to cell death. In patients suffering from Parkinson disease, the total amount of iron in the substantia nigra was reported to increase with disease severity. High concentrations of iron were also found in the amyloid plaques and neurofibrillary tangles of human Alzheimer disease brains. Besides iron, nitric oxide (NO) produced in high concentration has been associated with neurodegeneration. NO is produced as a co-product when the enzyme NO synthase converts L-arginine to citrulline, and NO has a role to support normal physiological functions. When NO is produced in a high concentration under pathological conditions such as inflammation, aberrantly S-nitrosylated proteins can initiate neurodegeneration. Interestingly, NO is closely related with iron homeostasis. Firstly, it regulates iron-related gene expression through a system involving iron regulatory protein and its cognate iron responsive element (IRP-IRE). Secondly, it modified the function of iron-related protein directly via S-nitrosylation. In this review, we examine the recent advances about the potential role of dysregulated iron homeostasis in neurodegeneration, with an emphasis on AD and PD, and we discuss iron chelation as a potential therapy. This review also highlights the changes in iron homeostasis caused by NO. An understanding of these mechanisms will help us formulate strategies to reverse or ameliorate iron-related neurodegeneration in diseases such as AD and PD.
An Analysis of the Effectiveness of Using Exclusively Workshop-style Instruction in the College Algebra Classroom, Focused on Engineering and Engineering Technology Undergraduates

Jennifer Vandenbussche is an Assistant Professor of Mathematics at Southern Polytechnic State University. In addition to her research in the scholarship of teaching and learning, she does mathematics research in in the area of combinatorics, especially extremal graph theory. Her primary interest lies in coloring and matching problems in graphs. She received her Ph.D. in Mathematics from the University of Illinois at Urbana-Champaign.
Fatigue and Physiotherapy In Liver Transplant Recipients Fatigue and Physiotherapy

Liver transplantation surgery is a life-saving treatment option for life-threatening end-stage liver diseases and acute liver failure. While the health-related quality of life of liver transplant recipients is related to the success of the transplantation procedure; fatigue, malnutrition, loss of muscle mass, decrease in exercise capacity, negative respiratory and metabolic changes as the findings of organ failure are among the causes of functional loss in the posttransplant period. The prevalence of the fatigue, as the frequently experienced symptom in the end-stage liver diseases, varies depending on the specific forms of liver disease and it adversely affects pre and postoperative functional levels of the patients, liver transplantation results and also survival. The severity of the fatigue decreases after the transplantation surgery, but it continues to be seen as the most compelling clinical symptom experienced during the postoperative first year. Current literature data emphasize the necessity of physiotherapy programs and active early mobilization which applied in the early period in the intensive care unit following transplantation surgery and physiotherapy and rehabilitation approaches including strength and endurance training contributes to the functional level in this population. These findings suggest that there is a need for structured physiotherapy programs in order to increase muscle strength and exercise capacity and prevent fatigue.
An alpha-numeric character generator for a computer display.

Thin thesis describes the logical design and im­ plementation of an economical cathode ray tube alpha-numeric display unit for a Digital Equipment Corporation PDP-8/S digital computer. The above device is capable of displaying a part of the stored data in the computer memory on a cathode ray tube screen at the rate of approximately 200 characters per second with good legibility and flicker-free. This rate could be increased depending upon the writing speed of the oscilloscope used. Each displayed character is formed by a series of dots selected from a 5 x 7 matrix of dots. These dots are in turn generated on the cathode ray'tube screen by a set of unblanking pulses, fed to the Z-axis of the cathode ray tube in synchronism with the blanked beam movement. A storage oscilloscope is used to overcome the flicker problem obviating the use of a delay line memory or a core memory. This greatly reduces the cost of the who­ le unit. Any conventional storage oscilloscope having a saw­ tooth output can be used for the purpose. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. A suitable time base circuit has been designed and constructed for providing flexibility in positioning the ch­ aracter on the screen and also control over the start,stop operation of the device. The main advantage of this device lies in its si­ mplicity in logical design. It also affords the flexibility for changing the shape of the character by a suitable addi­ tion and/or deletion of any of the pulses that go to make up the character.
FREQUENCY OF INTRAPARTUM COMPLICATIONS IN PREGNANT OBESE WOMEN AT TERM

Objectives: To determine the frequency of intrapartum complications in pregnant obese women at term.Material and Methods: This study was conducted at Kalsoom Maternity Hospital, Peshawar, Pakistan. Study design was descriptive cross sectional which was done in the time period of 15 Months (from August 2010 to November 2011). The sample size was 126, using 95% confidence level, 11.1%3 proportion of instrumental delivery (as per CPSP rule the variable with minimum prevalence is to be taken for sample size calculation) and margin of error of 5.5%, under WHO software for sample size determination. More over non probability, consecutive sampling technique was used in this study.Results: In this study mean age was 28 years ± 3.92 SD. Mean BMI score was 33 Kg/m2 with standard deviation ± 1.82. thirty eight percent patients were primi gravida while 62% patients were multi gravida. More over 30% patients had cesarean section while 15% patients had instrumental deliveries in which 10% patients had vacuum delivery and 5% patients had forceps delivery.Conclusion: Cesarean section, gestational diabetes, meconium stained liquor, macrosomic babies, pregnancy induced hypertension, reduced rate of vaginal birth after cesarean section, failure to progress of labour in first stage, failure to progress in 2nd stage of labour, stillbirth, and preeclampsia are the complications of obesity.
Pattern analysis of lower limb magnetic resonance images in Korean patients with distal myopathy

http://www.e-acn.org pISSN 2508-691X eISSN 2508-6960 copyright © 2019 the Korean Society of clinical neurophysiology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Pattern analysis of lower limb magnetic resonance images in Korean patients with distal myopathy
Haploidentical haematopoietic stem cell transplantation for TP53‐mutated acute myeloid leukaemia

Acute myeloid leukaemia (AML) patients with tumour protein p53 (TP53) mutations are often resistant to chemotherapy and have worse clinical outcomes than patients without TP53 mutations. In this study, we compared clinical outcomes of patients with AML with and without TP53 mutations who underwent haploidentical haematopoietic stem cell transplantation (haplo‐HSCT). For the TP53‐mutation group and TP53 wild‐type group, the 2‐year cumulative incidence of relapse (CIR) was (39.0% vs. 21.2% respectively, p = 0.088), the 2‐year non‐relapse mortality (NRM) rate was (3.2% vs. 8.4% respectively, p = 0.370), the 2‐year leukaemia‐free survival (LFS) was (57.7% vs. 71.3% respectively, p = 0.205), the 2‐year overall survival (OS) rate was (69.9% vs. 81.3% respectively, p = 0.317), the 100‐day cumulative incidence of Grade II–IV acute graft‐versus‐host disease (GvHD) was (6.5% vs. 20.7% respectively, p = 0.074), the 2‐year cumulative incidence of chronic GvHD was (52.3% vs. 53.1% respectively, p = 0.493) and the 2‐year GvHD‐free/relapse‐free survival (GRFS) was (57.7% vs. 69.6% respectively, p = 0.347). Our data showed that there were no significant differences in 2‐year clinical outcomes between the two groups. Multivariable analysis showed TP53 mutations had no significant impact on CIR, NRM, OS, GvHD, LFS or GRFS. Our findings suggest that patients with AML with TP53 mutations may at least partially benefit from haplo‐HSCT. Haplo‐HSCT might be the recommended treatment for such patients.
Aberrant expression of long non-coding RNAs in peripheral blood mononuclear cells isolated from patients with gouty arthritis

Gouty arthritis (GA) is the most common inflammatory and immune-associated disease, and its prevalence and incidence exhibit yearly increases. The aim of the present study was to analyse the expression profile variation of long non-coding RNAs (lncRNAs) in GA patients and to explore the role of lncRNAs in the pathogenesis of GA. The peripheral blood mononuclear cells of GA patients and of healthy controls (HCs) were used to detect for the differentially expressed lncRNAs by microarray. The functional annotations and classifications of the differentially expressed transcripts were predicted using Gene Ontology (GO) and pathway analysis. The results were then verified by reverse transcription-quantitative (RT-q)PCR. A total of 1,815 lncRNAs and 971 mRNAs with a >2-fold difference in the levels of expression in the GA patients compared with those in the HCs were identified. According to the GO functional enrichment analysis, the differentially expressed lncRNAs were accumulated in terms including protein binding, catalytic activity and molecular transducer activity. The pathways predicted to be involved were the tumor necrosis factor signaling pathway, osteoclast differentiation, NOD-like receptor signaling pathway and NF-κB signaling pathway. The expression of six lncRNAs was measured by RT-qPCR and the results were consistent with those of the microarrays. Among these lncRNAs, AJ227913 was the most differentially expressed lncRNA in GA patients vs. HCs. The expression of several lncRNAs was significantly changed in GA patients compared with that in HCs, which suggests that these lncRNAs with differential expression levels may have an important role in the development and progression of GA.