Miracle-dz/UniFAR-FTUs huggingface dataset:
Parent-Adolescent Communication as a Protective Factor Against Adolescent Alcohol and Tobacco Use: Reported Narratives From Youth From Latinx Farmworker Families

Due to high stressors and inequities, youth from Latinx migrant farmworker (LMFW) families may experience an elevated risk of early drinking and smoking. Parent-adolescent communication can protect against early initiation, but few researchers have explored this parenting practice in LMFW families. This qualitative study used youth-reported narratives to examine messages LMFW parents convey when discussing drinking and smoking, if these messages varied by age, youths’ feelings toward these discussions, and if these discussions promoted resilience against drinking and smoking among youth. Twenty-four LMFW youth (67% boys, Mage = 13.88, 79% born in the United States) were recruited from a summer Migrant Education Program in Indiana. Using thematic analysis, five themes were identified from youth interviews: (1) mostly older youth used substances, but nearly all youth stated that parent’s expressed disapproval toward underage drinking and smoking; (2) parent-adolescent discussions left youth feeling positive and confident; (3) parents used consejos to communicate about alcohol and tobacco; (4) parents were lenient toward drinking and smoking in older male teens; and (5) some parents did not offer reasons for why youth should avoid drinking and smoking or rules pertaining to these substances. Our findings have implications for research and interventions aimed at fostering parent-adolescent communication in LMFW families about alcohol and tobacco use.
Application of Becton Dickinson FACSTM Combinatorial Antibody Profile (FACSTM CAP) technology to the identification of efficiency of tuberculosis therapy

ii Abstrak . iv Acknowledgements . vi List of figures . xv List of Tables . xvi List of abbreviations . xvii Chapter 1: Introduction . 1 1.1. Epidemiology of tuberculosis. 1 1.2. Problems facing tuberculosis . 2 1.3. Mtb and Immunity . 3 1.3. 1. Innate immune response . 4 1.3. 1.1. Chemical factors . 4 1.3. 1.2. Cellular factors . 6 1.3. 1.2.1. Granulocytes . 6 1.3. 1.2.2. Macrophages . 7 1.3. 1.2. 3. Dendritic cells . 7 1.3. 1.2. 4. Natural killer cells (NKs) . 7 1.3. 2. Adaptive immune response . 8 1.3. 2.1. Antibody-mediated response (humoral) . 8 1.3. 2.2. Cell mediated response . 9 1.3. 2.2.1. T cells . 9 1.3. 2.2.1.1. CD4+ T helper cells . 9 1.3. 2.2.1.2. CD4+ effector T cells . 10 1.3. 2.2.1.3. CD8+ cytotoxic T cells . 10 Stellenbosch University https://scholar.sun.ac.za
Response to Dasatinib in Patients with Aggressive Systemic Mastocytosis with D816V Kit Mutation.

Human systemic mastocytosis (SM) is a rare disease caused by an abnormal mast cells accumulation in various tissues. It usually occurs as a sporadic disease that is often persistent or progressive in adults. Clinical course is variable. The most aggressive forms have a rapid course and required treatments to reduce the neoplastic burden and to slacken the progression. Unfortunately no therapy have been demonstrated efficacy, mostly in the treatment of aggressive systemic mastocytosis (ASM). SM has been associated with constitutive activating c-kit somatic mutations, the most frequent of whom is the D816V mutation. Kinase inhibitors blocking constitutive c-kit activation, such as imatinib, have been used in SM, but they had no effect on D816V mutant kit. Here, we report on six patients with Systemic mastocytosis and with detectable D816V mutation treated with dasatinib 70 mg BID as in leukemia treatment. According to the WHO Classification of Systemic mastocytosis, we describe clinical characteristics of six cases of ASM with different organ damage treated with dasatinib for various period, and we made evaluation of response according to Valent criteria (Leuk Research, 2003). All patients excepting Patient 3 reached the dose of 140 mg daily. Patient 4 are on treatment after 10 months, without any signs or symptoms of disease progression. Patient 2 is still on treatment with low dose of dasatinib (20 mg daily) but he shows cytopenia and worsening clinical condition, he does not tolerate high dose of dasatinib for gastrointestinal toxicity and astenia. Patient 1 stopped therapy after 10 months of therapy and she relapsed with ascite and died after 1 month for progressive disease. Patient 3 and Patient 5 interrupted dasatinib for worsening clinical condition after 40 days and three months respectively. Patient 6 stopped dasatinib after five months for progression to acute leukemia. After dasatinib suspension, Patient 3 died for complication of leg fracture and Patient 5 died for progression of disease. We observed major response in three patients for the prompt resolution of sign of organ damage recorded during dasatinib treatment, and we also obteined a measurable decrease of the burden of neoplastic MCs by means of tryptase level monitoring in all but one patients. Toxicity of 140 mg daily in patients with advanced ASM is notable. All patients had to suspended therapy due to extra-haematological toxicity. The most commonly toxicity involved gastroenteric tract, with diarrohea and abdominal pain, hypotension and pleural effusion. Symptoms resolved or return to mild grade with dose reduction, but in frail patients therapy is not well tolerate. After interruption of therapy progression was recorded.
Cathepsin D activity in the blood serum and urine in patients with colonic adenocarcinoma

aspartylową. Jest jednym z enzymów kaskady proteolitycznej zaangażowanej w inwazję nowotworową i tworzenie przerzutów. Jej obecność stwierdzono zarówno w tkankach prawidłowych, jak i nowotworowych. Katepsyna D uczestniczy w penetracji guza w tkankach, migracji komórek nowotworowych i ich umiejscowieniu w ogniskach przerzutowych. Przeprowadzone badania miały na celu ocenę przydatności diagnostycznej oznaczania aktywności katepsyny D u chorych na gruczolakoraka jelita grubego. Badanie przeprowadzono w surowicy krwi i moczu 9 chorych, w wieku od 56 do 81 lat, z rozpoznanym histopatologicznie rakiem jelita grubego (adenocarcinoma), leczonych w I Klinice Chirurgii Ogólnej i Endokrynologicznej AM w Białymstoku, oraz 6 osób zdrowych w wieku od 28 do 40 lat, stanowiących grupę kontrolną. Aktywność katepsyny D oznaczano metodą Folina-Ciocalteau w modyfikacji miedziowej i wyrażano ją w surowicy krwi w nmol Tyr/ml/6 godz. , a w moczu w nmol Tyr/mg białka/6 godz. Stężenie białka w moczu oznaczano metodą Lowry, a wyniki wyrażano w mg/ml. Aktywność katepsyny D w surowicy krwi chorych na raka jelita grubego była istotnie (o ponad półtora raza) wyższa od aktywności tego enzymu u osób zdrowych (p<0,003). Wyniki badań moczu wskazywały na obniżenie aktywności katepsyny D w gruczolakoraku jelita grubego w porównaniu z osobami zdrowymi. Brak jest natomiast istotnych statystycznie różnic zarówno aktywności katepsyny D (p=0,426), jak i stężenia białka (p=0,139) w moczu chorych na gruczolakoraka jelita grubego, a grupą osób zdrowych. Wyniki sugerują możliwość wykorzystania aktywności katepsyny D w surowicy krwi jako markera gruczolakoraka jelita grubego.
Evidence of Aseismic and Fluid‐Driven Processes in a Small Complex Seismic Swarm Near Virginia City, Nevada

Analysis of a small earthquake swarm near Virginia City, NV, reveals complex structural features, including an interplay of both fluid‐driven and aseismic‐driven earthquake migration within a naturally occurring tectonic sequence. The Virginia City earthquake sequence occurred over ~10 days in January 2014. We relocate 305 events to reveal three separate, well‐defined planar structures. The earthquakes initially migrate at a rate consistent with pore fluid diffusion, outlining a moderately dipping plane. The earthquakes then jump to a vertical plane and migrate at a higher rate; the sequence continues to migrate rapidly onto a third, shallowly dipping plane, consistent with rates observed elsewhere associated with aseismic creep. Focal mechanisms indicate right‐lateral strike slip on the vertical plane and both normal and left‐lateral strike slip movement on the other planes, and the newly imaged structures illuminate the orientation of active faults at depth in the Walker Lane tectonic region.
OXIDIZED LOW-DENSITY PROTEIN, INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR ALPHA LEVELS AND PARAOXONASE ACTIVITIES IN HYPERTENSIVE PATIENTS

Oxidative stress is thought to play a critical role in the pathogenesis of essential hypertension. Oxidized low-density lipoprotein (ox-LDL) has an important role during the atherosclerosis process and paraoxonase can significantly inhibit lipid peroxidation. We aimed to examine serum oxidized LDL, TNFa, LL-6 levels and paraoxonase (P0N1) activity as a biomarkers of oxidative stress in hypertensive patients. Thirty-eight hypertensive patients and twenty-two healthy control subjects were included in the study. Clinical assessment and blood pressure measurement were performed in patients. Serum Ox-LDL, TNF-a and LL-6 levels were measured by Enzyme-linked immunosorbent assay (ELLSA) method. P0N1 activities were measured by spectrophotom etric method. Ox-LDL and LL-6 levels were significantly higher in hypertensive patients compared to controls (p<0.01, p<0.01, respectively). P0N1 activities were found at low level in patients with hypertension compared to control group (p<0.01). Hypertensive patients were divided into two groups: dipper and non-dipper. Decreased Ox-LDL and TNF-a levels were found in dipper patients compared to non-dipper patients (p< 0.01, p<0.01, respectively). P0N1 activities were found higher in dipper patients than those of non-dipper patients (p<0.05). Increased OxLDL, LL-6 levels and decreased P0N1 activities in hypertensive patients might indicate increased oxidative stress, which plays an important role in the development of cardiovascula r diseases. Dipper patients had mild signs of oxidative stress compared with non-dipper patients.
Epigenetics in disease etiopathogenesis

The term epigenetics refers to heritable changes in gene expression that are not caused by modifications in DNA sequence. Epigenetic changes are DNA methylation, histone modifications, nucleosome positioning, and non-coding RNA (including microRNA) mediated modifications. Epigenetic mechanisms are involved in malignant diseases, imprinting defects, and some hereditary diseases. Recent research explained the role of epigenetic disorders in infections, autoimmune, neurodegenerative and bone diseases, as well as in psoriasis, endometriosis, and polycystic ovary syndrome. Epigenetic modifications have a potential clinical application as diagnostic and prognostic biomarkers, and also as therapeutic targets in oncology, endocrinology, cardiology, and neuropsychiatry. Stress, anxiety, depression, emotions and many other psychological factors may affect epigenetic mechanisms. Influence of preconception parental stress exposure transmits to the next generation through epigenetic changes, as direct results of prenatal and postnatal environmental factors. Epigenetic changes identify environmental factors which affect health and cause disease onset. Milk is the sophisticated system of communication between mother and infant, operating via epigenetic mechanisms. Lifelong consumption of bovine milk causes epigenetic disorders. Recent studies provide important information about the role of bioactive dietary nutrients which modify epigenome in malignancy prevention and therapy. Any interruption in the balance of intestinal microbiota initiates aberrant epigenetic modifications. Epigenetic patterns act as the ? molecular watches? and they play the central role in the establishment of biological rhythms. Epigenetic mechanisms can determine the result of assisted reproductive technology and genetic engineering. The extensive research about the association of epigenetics and pharmacology led to the development of pharmacoepigenetics. All these results emphasize the importance of further research which will take into account all factors that may affect epigenetic mechanisms.
Laserski snimak Trsatskog kaštela kao dio strategije očuvanja kulturne baštine Rijeke

Trsat castle is one of the most famous heritage elements in Primorsko-goranska County. In 2015, as part of the renewal design, the City of Rijeka has commissioned the survey of the complex (almost 8000m²). The survey was done using the laboratory equipment of University of Rijeka. The aim of the paper is to illustrate the survey process, to analyze the possibility of combining laser scanning with other contemporary methods (drone survey, photo-modelling.), as well as to compare the results of the survey with the previous surveys of the complex, and to determine new data about the complex and discuss the results, especially the importance of such a complex survey for cultural heritage preservation.
Adapting to staying, or imagining futures elsewhere: Migration decision-making of Syrian refugees in Turkey

There is a lack of research into the question of how refugees make migration decisions. Building upon the literature concerning migration aspirations and drivers of migration in contexts of forced displacement, this working paper examines the questions of how and why Syrian refugees in Istanbul and Izmir experience mobility and immobility. Drawing on the findings of a mixed-methods study conducted in 2018 amongst refugees in those two cities, it disentangles the many different ways of staying in Turkey. It offers insights into the perspectives of Syrians who aspire to return to Syria but stayed; those who want to remain in the country; those who aspire to move on to another country but stayed; and those who left for Europe but returned to Turkey. The findings of this study show a strong desire to return among the Syrian refugee population in Turkey, should the conflict come to an end. It also finds moderate aspirations to stay in Turkey, and a strong resistance to the idea of migrating further, into Europe. However, aspirations with regard to return and onwards migration were higher than actual migratory behaviour on the ground. The paper highlights that subjective factors such as life satisfaction, imaginings of the future, and hope, are crucial factors at the micro-level that shape refugees’ migration decision-making on a micro-level. The hope for return, one day, to Syria had initially motivated many Syrians to remain in Turkey. However, a combination of having given up hope of safely returning to Syria in the future, relatively high life satisfaction in Turkey, and negative ideas about what life in Europe might entail, have led Syrians to consider settling down in Turkey. Access to work is perceived as being easier there than in Europe, and a sense of a common cultural belonging has created strong counter-narratives to Europe as a potential destination.
Transgenerational effects of the plasticizer di-2-ethylhexyl phthalate on survival, growth, and reproduction of Daphnia magna

Global production of plastic materials has increased twenty-fold over the last fifty years, exceeding 300 million tonnes in 2015 [1]. Worldwide, a great amount of plastic waste is left unmanaged [2] and, more seriously, less than 5% of discarded plastic materials has been recovered [3]. Consequently, the continuous increase of plastic use over time has negative effects on the environment, especially water bodies. Plastics are known to contain a great number of additives, e.g., bisphenol A and phthalates, among others. Phthalates and their isoforms are among the most commonly used solvents in various industrial and consumer products, and the global production of phthalates is estimated to be between 6 and 8 million tons annually [4]. The existence of phthalates in the environment has been reported by many countries such as Finland, Denmark, Germany, Japan, China, Thailand, Poland, Sweden, and Italy [5]. While bisphenol A is known as both an oestrogen agonist and an androgen antagonist, impacting both reproduction and development in crustaceans and insects, phthalates have been shown to cause molecular and whole-organism effects in vertebrates and invertebrates [6]. Besides, phthalates desorbed from plastic have been known to accumulate in the gut of organisms resulting in disorder of biological processes such as endocrine disruption and behavioural alterations [7]. Transgenerational effects of the plasticizer di-2-ethylhexyl phthalate on survival, growth, and reproduction of Daphnia magna
Structural injustice and the Requirements of Beauty

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Soil Microbial Communities in Long-Term Soil Storage for Sand Mine Reclamation

The success of ecosystem restoration following mining could be improved through consideration of the soil microbial community, which forms the foundation of ecosystems. Through sequencing we can assess the response of the microbial community to stresses such as stockpiling, and measure community recovery. We sequenced fungal and bacterial communities associated with intact Banksia woodland reference soils and stockpiled topsoil stored for one to ten years following sand mining in Western Australia. We found that both bacterial and fungal richness declined, but that the fungal community returned to a state similar to reference soils, whereas the bacterial community did not. Notably, Bradyrhizobium was absent from 10-year soils, indicating a possible lack of inoculum available to colonize legumes that are often used for revegetation. Soil fungi and bacteria respond differently to stockpiling and key taxa such as Bradyrhizobium could be lost. In addition, changes in the bacterial community may signal a reduction in plant-available nitrogen and a shift towards more anaerobic conditions consistent with previous studies. These changes in microbial communities support previous findings of reduced plant performance on 10-year stockpiled soils and emphasize the importance of considering soil age during restoration.
Psychiatric aspects of abortion

Abstract Objective: To examine the evidence concerning the psychological consequences of abortion, the risk of suicide in pregnancy and the psychological consequences for the mother and the child in cases of refused abortion. Method: An extensive literature search was undertaken and key relevant papers were examined and analysed. Results: Legal abortion has become more widely available throughout the western world and the actual reported incidence of cases of refused abortion is low. The majority of studies indicate that the psychological consequences of abortion itself are in the main mild and transient but there is evidence that women who have strong religious or cultural attitudes negative to abortion do experience high levels of psychological stress following abortion. The risk of suicide is low in pregnancy and suicide is a rare outcome of refused abortion. There is evidence of psychological and social difficulties experienced by mothers of unwanted pregnancies forced to proceed to term and by many offspring of such unwanted pregnancies. Conclusions: Definitive conclusions are difficult to draw from the published studies of refused abortion and many studies are over thirty years old.
Daily Smartphone Use for Work and Its Effect on Work-Life Conflict among Integrators

This daily diary study investigates the effects of daily smartphone use for work during off-work hours on work-life conflict. Drawing on role theory which supports the notion that segmentation is a boundary management strategy, the moderating effect of individual’s segmentation preference is proposed. Results of multilevel regression analyses showed that smartphone use for work was positively related to work-life conflict. The result also shows that the preference to integrate work and personal life rather than separate these domains strengthened the relation between smartphone use for work and work-life conflict. The results of this study may help human resource practitioners to better understand the impact of staying connected to work during off-work hours. Keywords: Daily smartphone use; Work-life conflict; Segmentation preference; Diary study
Extraction of Active Components of Aloe Vera to Treat Acne/pimple in Population of Quetta City

Comprehensive study of local aloe vera and its effects on acne/pimple was performed. The work mainly describes the chemical investigation of aloe vera by traditional methods to check its efficacy in the treatment of acne. Local aloe specie was gown and solutions of different concentration were made. Samples of acne were collected from different acne sufferers to identify the microbe which is major cause of acne infection. Doses of different concentrations of aloe vera were tested on the acne causing microorganism. In the present work traditional methods of plant extraction were used to find the relationship between aloe vera and acne treatment.Doses of different concentrations were calculated and analyzed to treat acne.
What we know about research policy mix

The research policy (RP) arena has been transforming in recent years, turning into a policy mix encompassing the diversity of policy instruments embedded in, and following different policy rationales and aims. Its complexity defies attempts for complex comparative analysis and eventually, a better understanding of what kind of (mixes of) funding instruments work better than others and in which situations. In this article, we address this gap by developing a conceptual framework that allows us to build the policy mix idea into the analysis of research funding instruments (RFIs), by relying on four dimensions: policy rationales, implementation modalities, policy actors, and the funding instruments interactions. We base our work on a careful literature review, especially drawing on the work of researchers who have developed similar frameworks in other policy areas, bringing it together with that of RP scholars, capturing the issues that are key to analyzing and understanding RFIs.
Co-occurring Mental Illness among Clients in Chemical Dependency Treatment

HIS REPORT provides detailed information on clients receiving chemical dependency services through the Washington State Health and Recovery Services Administration (HRSA), Division of Behavioral Health and Recovery (DBHR/CD; formerly Division of Alcohol and Substance Abuse) who have indications of co-occurring mental health problems. Co-occurring disorder (COD) rates and characteristics are presented for those chemical dependency clients identified as having co-occurring mental health problems, including demographics, mental health diagnostic categories, services received, and COD rates by service modality. We have also provided analysis of the overlap between the two COD indicators presented in an earlier report to the legislature and an additional mental illness indicator constructed from assessment items.
The employment effects of trade policy reform in Myanmar

This paper investigates employment responses to trade liberalisation in a developing economy, Myanmar. Using data from the 2014 Census and the 2017, labour force survey and previous surveys contained in Myanmar Statistical Yearbook, 2017, we find that trade liberalization did not affect the relative size of industry sectors in terms of employment. The OLS results finds support for the theoretical predictions of differential responses to trade reforms between sectors. Conversely, while empirical support is found for tariff reduction in influencing sector level employment, the tariff predictors are weaker overall than the sector productivity and competitiveness (in export market) predictors—implying that trade policy reforms need to be correctly tailored to raising productivity of labour force and sector competitiveness if their impact on employment is to be effectively realised.