Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship Between Laboratory and Ambulatory Cardiovascular Activity: Current Evidence and Future Directions1–3

This review examines studies which have investigated the relationships between laboratory and field cardiovascular activity. These studies explore associations between cardiovascular data collected during typical laboratory stress-testing paradigms and data collected via ambulatory monitoring while subjects are engaged in their usual activities outside the experimental laboratory. Despite the widely ranging methodologies and analytical techniques, it can be concluded that there is presently moderate evidence for laboratory-field generalization of cardiovascular activity, although the evidence varies in strength for different types of laboratory-field associations. Suggested future directions include the incorporation of several promising analytical techniques, consideration of physical activity and posture, the employment of ambulatory hemodynamic data when the advent of appropriate hardware permits, and the assessment of cardiovascular activity during both specific and non-specific stressors in a single paradigm.
An interventional simulation device

The present invention relates to an apparatus (100) of the simulation system, the simulation system for simulating surgical intervention. Apparatus (100) can accept a plurality of actual devices, preferably at least two. Apparatus (100) comprises a plurality of movable carriage (16A-16C), the number of carriage coincides with the actual instrument. Apparatus (100) further comprises a track (20) and an interconnecting member (26). Interconnecting member (26) in turn connected to the carriage (16A-16C). Each carriage (16A-16C) has an opening, in order to ensure receiving device. Each carriage (16A-16C) further comprises a locking member and at least one receiving device of the mobile device and the receiving member and generates a force, a reaction force characteristic in terms of instruments to simulate.
SP 800-52. Guidelines for the Selection and Use of Transport Layer Security (TLS) Implementations

These Guidelines briefly introduce computer communications architectural concepts. The Guidelines place the responsibility for communication security at the Transport layer of the OSI seven-layer communications stack, not within the application itself. Protection of sensitive but unclassified Government information can adequately be accomplished at this layer when appropriate protocol options are selected and used by clients and servers relying on transport layer security.
Smart Controller Design for Solar Grid Integration and LVDC Distribution System

Nowadays Direct Current (DC) Distribution Systems have started to attract a lot of attention as they offer a natural interface to generation and consumption units such as renewable energy sources, energy storage systems and end-user electronic loads. However, a number of technical challenges related to integration of renewable energy sources and their control must be overcome. This paper presents a smart controller based design for efficient and cost effective operation of a LVDC Distribution System. This paper mainly focuses on solar energy as it is the most abundantly available renewable energy source. This paper basically presents a smart controller based design for cost effective operation of solar-grid tied LVDC system. The control strategy used in this system helps to achieve the maximum efficiency as utilization of dump power is also considered. This system is defined to fill the necessity of regions where solar power is used only as backup purposes to charge the battery and is actively dumped during the presence of active grid. The system has been tested for a solar panel with a battery backup storage and its effectiveness has been observed. The battery backup is made to operate during the Grid cutoff. 
Evidence-Based Information Systems: A New Perspective and a Road Map for Research-Informed Practice

Despite the increasing sophistication and quality of published work, the development of a cumulative body of knowledge and an evidence-base for Information Systems (IS) research still represents a major challenge. IS research is still predominantly undertaken by IS researchers for other IS researchers and not utilized to its full extent by IS practitioners or policy makers. We focus on this problem and express the need for a new evidence-based research perspective. It is argued that it is time to refocus the efforts of IS academics (and practitioners) to develop a new evidence-base for IS research whereby it can more routinely inform, develop, improve and support IS practice. We contribute to this debate by defining evidence-based practice (EBP), its relevance to IS, and the need to develop an evidence-based approach. We look in particular at its brief history, and its subsequent evolution, development and widespread acceptance in Medicine; making reference to recent arguments and critiques of EBP in other disciplines such as software engineering and management. We espouse the need to develop a similar evidence-based movement and infrastructure within the IS research and practitioner communities and then put forward a possible roadmap for the development of Evidence-Based Information Systems (EBIS) that comprises 9 key initiatives. We conclude our argument by stating that the current extent, severity and impact of IS failures are unacceptable, emphasizing the need for a new perspective for IS research that encourages and incorporates EBP as a guiding principle to inform better IS practice.
Hearing Loss at 250 Hz Can Differentiate Between Different Subtypes of Tinnitus: A Retrospective Chart Review

Introduction: Patients suffering from tinnitus are a heterogeneous group. Different subtypes may indicate a different pathogenesis. The subgroups need to be identified in order to find effective treatments. Objectives: The aim of this study was to identify the characteristics of unilateral and bilateral tinnitus to differentiate between different subtypes, using history, audiograms and radiographs of the cervical spine. Methods: A retrospective chart review of 95 consecutive patients with tinnitus that persisted for one month or longer was performed. Results: Patients with unilateral tinnitus had a statistically significant lesser hearing from 250 Hz to 1 KHz compared to bilateral tinnitus. There were no statistically significant differences in radiographic measurements between both groups. Multivariate analysis indicated that hearing loss at 250 Hz was the strongest variable associated with the presence of uni-and bilateral tinnitus. In patients with tinnitus, a hearing loss of more than 23 decibels at 250 Hz was characterized by a high prevalence of self-perceived hearing loss (92% of the patients), balance disorders (75% of the patients), vertigo (63% of the patients), and unilateral tinnitus (54% of the patients). Conclusion: Two subgroups of patients with tinnitus suggest two different pathogenesis: otogenic and non-otogenic tinnitus. Hearing loss at 250 Hz of more than 23 decibels could differentiate between the two forms. There was a higher prevalence of unilateral tinnitus in patients with otogenic tinnitus compared to patients with non-otogenic tinnitus.
Rancang Bangun Low Power Sensor Node Menggunakan Msp430 Berbasis Nrf24l01

Teknologi komunikasi saat ini sudah sangat berkembang terlebih lagi dengan adanya teknologi wireless. Teknologi ini sangat populer dikarenakan kemampuanya dalam mengirimkan data atau informasi secara nirkabel. Salah satu pemanfaatan teknologi wireless adalah pada Wireless Sensor Network. Pada Wireless Sensor Network, pengiriman data antar sensor node sangat bergantung dengan sumber daya listrik berupa baterai yang mempunyai kapasitas daya terbatas, hal ini dapat menyebabkan masalah karena sensor node diharuskan dapat bertahan selama mungkin. Untuk menanggulangi masalah penghematan sumber daya, dilakukan penelitian tentang low power mode pada teknologi Wireless Sensor Network yaitu dengan cara menerapkan mekanisme sleep mode pada sensor node agar sumber daya baterai dapat bertahan lebih lama. Sesuai dengan masalah diatas, penulis membuat rancang bangun sensor node menggunakan MSP430 sebagai mikrokontroler yang akan mengatur segala proses pada node termasuk mengatur penggunaan sleep mode sebagai cara penghematan catu daya. Untuk pengiriman data, sistem ini menggunakan NRF24L01 sebagai modul komunikasi. Data yang dikirim berupa perhitungan suhu dari sensor suhu LM35. Hasil dari penelitian dalam hal penggunaan sleep mode dapat menghemat daya yang digunakan oleh node. Hal ini ditunjukan oleh penghematan daya yang digunakan oleh node tanpa menggunakan sleep mode dengan node yang menggunakan sleep mode mencapai 33,31 %. Akurasi pengiriman data pada penelitian ini dibagi menjadi 2, pada pengiriman data tanpa penghalang rata-rata akurasi pengiriman data mencapai 100%. Sementara pada pengiriman data dengan penghalang rata-rata akurasi pengiriman data hanya mencapai 87,7%.
the Performance of Object Tracking with Projection-Based Visual Servoing Method

the Performance of Object Tracking with Projection-Based Visual Servoing Method ○ 王 俊祥 (岡山大) 正 田 宏志(岡山大) 寇 ギョウ郡 (岡山大) 舟久保 龍希(岡山大) 李 想 (岡山大) 山本 太郎(岡山大) 正 松野 隆幸 (岡山大) 正 見浪 護(岡山大) Junxiang WANG, Okayama University, p6386zth shinj@s.okayama-u.ac. jp Hongzhi TIAN, Okayama University Yejun KOU, Okayama University Ryuki FUNAKUBO, Okayama University Xiang LI, Okayama University Taro YAMAMOTO, Okayama University Takayuki MATSUNO, Okayama University Mamoru MINAMI, Okayama University This paper proposes a visual servoing system based on a projection-based recognition method. The projection-based visual servoing system using only two calibrated cameras can identify the position and orientation of arbitrary-shaped unknown objects. For a visual servoing system, it needs to know the spatial dimension data of the observed object. However, in the detection of an unknown object, the visual servoing system generally directly obtains 2D images of the observed object, and doesn’t know the three-dimensional size. Especially the detection of distance is important. Through an inverse projective transformation, we have realized the spatial transformation of 2D to 3D. And a genetic algorithm which is called“ Real-Time Multi-Step Genetic Algorithm(RM-GA)”is used to solve on-line optimization problems. In this paper, the tracking ability of projection-based visual servoing method has been verified through arbitrary-shaped object tracking experiments. The results of experiments will be reported.
Increased Mortality Risk among Early Stage Hormone Receptor Positive Breast Cancer Patients Who Did Not Receive Adjuvant or Neoadjuvant Therapy

Background: Hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) is the most common biologic subtype of breast cancer. Although adjuvant therapy has demonstrated a survival benefit in clinical trials, its use is poorly understood in the real-world among elderly breast cancer patients since age is a barrier to receiving adjuvant therapy. An examination of treatment patterns and outcomes associated with receipt of adjuvant/neoadjuvant therapy among elderly HR + HER2-breast cancer patients was undertaken. Methods: There were 18,470 HR + HER2-breast cancer patients from the linked SEER-Medicare database. Patients were diagnosed with stage I-III disease between 1/1/2007-12/31/2011, ≥66 years, enrolled in Medicare Parts A, B and D, and underwent breast cancer surgery after diagnosis. Time-varying Cox proportional hazards regression assessed overall survival. Results: There were 13,670 (74%) patients treated with adjuvant/neoadjuvant therapy and 4800 (26%) untreated. Compared to treated patients, untreated patients were older, had earlier stage, lower grade, smaller tumors, poorer performance, higher comorbidity score, and less use of a 21-gene recurrence score (RS) assay (p < 0.0001). In the survival model, increasing age, stage, tumor size, tumor grade, comorbidity score and poor performance were significantly associated with higher mortality risks, while use of an RS assay was associated with lower risks. The Cox model showed a 48% higher risk of death in untreated compared to treated patients. In a subset of 8967 patients with stage I disease, tumor size < 2.0 cm and grade 1/2; untreated patients had a 22% higher risk of death compared to treated patients. Conclusions: Older patients with favorable clinical characteristics (earlier stage, smaller tumor, lower grade) are less likely to be treated and have a higher risk of death compared to adjuvant/neoadjuvant treated patients. An unmet need among older breast cancer patients persists.
Approach to the Extraction of Design Features of Interior Design Elements Using Image Recognition Technique

This paper aims to propose deep learning-based approach to the auto-recognition of their design features of interior design elements using given digital images. The recently image recognition technique using convolutional neural networks has shown great success in the various field of research and industry. The open-source frameworks and pre-trained image recognition models supporting image recognition task enable us to easily retrain the models to apply them on any domain. This paper describes how to apply such techniques on interior design process and depicts some demonstration results in that approaches. Furniture that is one of the most common interior design elements has sub-feature including implicit design features, such as style, shape, function as well as explicit properties, such as component, materials, and size. This paper shows to retrain the model to extract some of the features for efficiently managing and utilizing such design information. The target element is chair and the target design features are limited to functional features, materials, seating capacity and design style. Total 3933 chair images dataset and 6 retrained image recognition models were utilized for retraining. Through the combination of those multiple models, inference demonstration also has been described.
Robust Positive Position Feedback Controller for Voltage Control of Islanded Microgrid

This paper presents the design of robust positive position feedback (PPF) controller to control the grid voltage for an islanded microgrid. The microgrid consists of several distributed generators (DG) and local loads which is partially unknown and uncertain. The controller is designed in a way that it shows the robustness against unmodeled loads, dynamic loads and harmonic loads. The dynamics of the plant is identified using differential equations. The design of the controller is presented based on negative imaginary approach. The simulation results presented in the paper show that the controller provides extensive improvement in the voltage control of islanded microgrid under different uncertainties.
Qualitative Phytochemical Analysis and Antimicrobial Activity of Piper sarmentosum Leaves Extract Against Selected Pathogens

The controversial usage of antiseptic in treating wound infections had become a huge issue over the years due to its minimal effectiveness and high toxicity level that are harmful to humans. Hence, numerous studies had been carried out to determine other possible approaches including herbal remedies. The alarming situation had led us to study on Piper sarmentosum and its antimicrobial activity against selected pathogens. In present study, methanol extract of Piper sarmentosum leaves were prepared to investigate the presence of phytochemical compounds. The in vitro antimicrobial activity of crude methanolic extract was evaluated using disc diffusion and microdilution broth methods. The study demonstrated the antimicrobial activity of leaves extract against Staphylococcus aureus (7 mm) and Escherichia coli (6.5 mm). However, no zone of inhibition was observed against Pseudomonas aeruginosa. Meanwhile, the MIC values for Staphylococcus aureus was 6.25 mg/mL whilst Escherichia coli was 12.5 mg/mL. In addition, the phytochemical screening results revealed that the extract contained glycosides, flavonoids, terpenoids, alkaloids, and phenolics. In conclusion, methanolic extract of Piper sarmentosum leaves has the potential as a new, effective alternative towards current drugs that are available for skin-associated infection. The findings from this study are crucial in providing latest information of the plant’s additional values that can be incorporated as a baseline for current and future studies as well as in investigating other possible plants that are beneficial for health purposes, particularly for combating skin-associated infection. DOI : http://dx.doi. org. /10.17576/JSKM-2019-1701-09
Clinical Usefulness of Korean Red Ginseng in Postmenopausal Women with Severe Climacteric Disturbance

The aim of this study is to evaluate clinical usefulness of Korean red ginseng (RG) on various postmenopausal syndromes. Total plasminogen inhibitor-1 (tPAI-1) in peripheral blood from 9 postmenopausal women with climacteric syndromes (CS) was measured before and 3 months after treatment with daily oral administrat i on of 6g RG and that from 8 postmenopausal women without any CS was also measured as healthy controls. Blood samples were collected in the early morning on the bed-rest. Psychological conditions of postmenopausal women with CS were measured before and 3 months after treatment with RG using simplified menopausal index (SMI). In addition, OKETSU (blood stagnation) syndrome scores and KI deficiency (generalized energy stagnation) scores proposed by Terasawa et al., were recorded before and 3months after treatment with RG in postmenopausal women with CS and in healthy postmenopausal women. OKETSU syndrome scores and tPAI-1 levels in postmenopausal patients with CS were significantly (P P<0.01) higher than those in healthy postmenopausal women without CS. Similarly, SMI scores and KI deficiency scores in postmenopausal patients with CS were about three-fold higher than those without any CS. When RG was administered for 3 months, KI deficiency scores and OKETSU scores as well as SMI scores declined around the levels of healthy postmenopausal women. Although tPAI-1 levels significantly (P<0.05) decreased after treatment with RG, those did not reach the levels of healthy postmenopausal women. Clinical usefulness of administration of RG to postmenopausal women with CS was confirmed from evaluation not only by modern medicine but also by traditional KAMPO medicine.
Distributed task allocation optimisation techniques in multi-agent systems

A multi-agent system consists of a number of agents, which may include software agents, robots, or even humans, in some application environment. Multi-robot systems are increasingly being employed to complete jobs and missions in various fields including search and rescue, space and underwater exploration, support in healthcare facilities, surveillance and target tracking, product manufacturing, pick-up and delivery, and logistics. Multi-agent task allocation is a complex problem compounded by various constraints such as deadlines, agent capabilities, and communication delays. In high-stake real-time environments, such as rescue missions, it is difficult to predict in advance what the requirements of the mission will be, what resources will be available, and how to optimally employ such resources. Yet, a fast response and speedy execution are critical to the outcome. This thesis proposes distributed optimisation techniques to tackle the following questions: how to maximise the number of assigned tasks in time restricted environments with limited resources; how to reach consensus on an execution plan across many agents, within a reasonable time-frame; and how to maintain robustness and optimality when factors change, e.g. the number of agents changes. Three novel approaches are proposed to address each of these questions. A novel algorithm is proposed to reassign tasks and free resources that allow the completion of more tasks. The introduction of a rank-based system for conflict resolution is shown to reduce the time for the agents to reach consensus while maintaining equal number of allocations. Finally, this thesis proposes an adaptive data-driven algorithm to learn optimal strategies from experience in different scenarios, and to enable individual agents to adapt their strategy during execution. A simulated rescue scenario is used to demonstrate the performance of the proposed methods compared with existing baseline methods.
A Pilot Study Comparing of Two Therapy Regimens Following Carpometacarpal Joint Arthroplasty

ABSTRACT Purpose. The purpose of this pilot study was to compare two occupational therapy regimens following arthroplasty: thumb splint plus home program and thumb splint plus occupational therapy. Methods. Nine participants who underwent a ligament reconstruction and tendon interposition surgery of the carpometacarpal (CMC) joint of the thumb were randomly assigned to either receive a splint and occupational therapy intervention or receive a splint and a home exercise program. Participants were assessed preoperatively and 6 months postoperatively using standardized assessments of joint motion, hand function, strength, and self-reports of pain and functional ability. Results. In each group, participants improved on all measures after surgery but there were no significant differences between the groups. Conclusion. The results suggest that either occupational therapy regimen postsurgery is effective but because of the small sample size, the results should be interpreted with caution.
Thalidomide monotherapy or in combination with dexamethasone in patients with refractory multiple myeloma

w ostatniej dekadzie dotyczy3 przede wszystkim wprowadzenia wysoko dozowanej chemioterapii z podaniem autologicznych komórek progenitorowych krwi obwodowej. Ta metoda postêpowania zwiêkszy3a czêstoœæ uzyskiwanych ca3kowitych remisji do ok. 25 proc., ale nadal 5-letnie prze¿ycie chorych poddanych chemioterapii nie przekracza 50 proc., a mo¿liwoœci leczenia wznowy lub opornej postaci choroby s1 bardzo ograniczone [1, 2]. W aktywnym szpiczaku mnogim, podobnie jak w innych nowotworach, stwierdza siê zwiêkszon1 angiogenezê [3] oraz wzrost stê¿enia cytokin odpowiedzialnych za waskularyzacjê (zasadowy fibroblastyczny czynnik wzrostu – basic fibroblast growth factor – bFGF, naczyniopochodny œródb3onkowy czynnik wzrostu – vascular endothelial growth factor – VEGF, transformuj1cy czynnik wzrostu β – transforming growth factor β – TGFβ oraz czynnik martwicy guza – tumor necrosis factor – TNF) [4]. Za najwa¿niejszy czynnik wzrostu dla komórek szpiczakowych uznana zosta3a IL6. Koncepcje nowych strategii postêpowania, polegaj1cych na blokowaniu aktywnoœci IL6 poprzez przeciwcia3a monoklonalne dla IL6 lub przeciwcia3a dla receptorów IL6, do tej pory nie znalaz3y szerszego zastosowania klinicznego w terapii szpiczaka. [5].
DSSO-Directional Shrinking Search Optimization

Researchers are continuously trying to develop new heuristic search algorithms in the field of optimization. In this paper, a novel optimization technique has been proposed that tries to maximize the effectiveness of exploration and exploitation by the algorithms in the search of global optimum point. In this proposed algorithm, the points in the search regions are directing towards the global optimum point in the same time the search region is also starts reducing exponentially. A stochastic process has been added in the end of the algorithm to provide better exploitation of the search region. The performance of the algorithm has been compared with some well known optimization techniques and the derived empirical results on solving standard benchmark functions clearly signifies the high performance of the proposed algorithm.