Miracle-dz/UniFAR-FTUs huggingface dataset:
Tuberculosis Case Notification and Treatment Outcomes in West Gojjam Zone, Northwest Ethiopia: A Five-Year Retrospective Study

Introduction: Tuberculosis (TB) is a major public health concern in Ethiopia. Analysis of TB case notification and treatment outcomes is crucial to understand the TB control program performance. The current study was carried out to assess trends of TB case notifications, treatment success rate and factors associated with unsuccessful treatment outcome among TB patients in West Gojjam Zone of Amhara Region, Ethiopia. Method: A retrospective cohort study was conducted in West Gojjam Zone. Demographic and clinical data were reviewed for all TB patients registered between July 2007 and June 2012 at 30 randomly selected public health facilities of the study zone. In addition, annual case notification reports of the study zone were used to analyze trends in TB case notifications. Logistic regression analysis was used to assess the association between potential predictor variables and unsuccessful treatment outcomes. Results: Tuberculosis case notification for all forms of TB decreased from 203/100,000 population in 2007 to 155/100,000 population in 2012. Among patients whose treatment outcomes were evaluated, 94.4% were successfully treated, 0.3% had treatment failure, 1.5% defaulted and 3.7% died. In multivariate analysis, the odds of unsuccessful treatment outcome was higher among retreatment cases than new cases (adjusted OR, 3.44; 95% CI: 1.92, 6.19). HIV co-infected cases were more likely to have unsuccessful treatment outcome compared to HIV negatives (adjusted OR, 2.68; 95% CI: 1.92, 3.72). Conclusion: Tuberculosis case notification rates showed a decreasing trend between 2007 and 2012. The treatment success rate exceeded the 90% treatment success rate target as set by the WHO. Special attention is required for patients with high risk of unsuccessful treatment outcome. Therefore, retreatment cases, and HIV positive cases need strict follow up throughout their treatment period.
A comparative study of Bat and Cuckoo search algorithm for regression test case selection

Enhancing the software by either adding new functionality or deleting some obsolete capability or fixing the errors is called software maintenance. As a result, the software may function improperly or unchanged parts of the software may be adversely affected. Testing carried out to validate that no new errors have been introduced during maintenance activity is called Regression Testing. It is acknowledged to be an expensive activity and may account for around 60–70% of the total software life cycle cost. Reducing the cost of regression testing is therefore of vital importance and has the caliber to reduce the cost of maintenance also. This paper evaluates the performance of two metaheuristic algorithms-Bat Algorithm and Cuckoo Search Algorithm for selecting test cases. Factors that we have considered for performance evaluation are the number of faults detected and the execution time. The domain of study is the flex object from the Benchmark repository — Software Artifact and Infrastructure Repository. Extensive experiments have been conducted to collect and analyze the results. A Statistical test, F-test has also been conducted to validate the research hypothesis. Results indicate that the Cuckoo Search Algorithms perform a little better than Bat Algorithm.
c‐Abl induces stabilization of histone deacetylase 1 (HDAC1) in a kinase activity‐dependent manner

c‐Abl is a non‐receptor‐type tyrosine kinase that regulates various cellular events, including cell proliferation, differentiation, and apoptosis, through phosphorylation of cytoplasmic and nuclear targets. Although we showed that c‐Abl induces histone deacetylation, the molecular mechanisms of this phenomenon are largely unknown. Here, we analyzed the effect of c‐Abl on the expression of histone deacetylase 1 (HDAC1), because c‐Abl was shown to be involved in maintenance of nuclear protein levels of HDAC1. Co‐transfection of HDAC1 with c‐Abl increased the levels of HDAC1 protein in a kinase activity‐dependent manner without affecting its mRNA levels. Treatment with the proteasome inhibitor MG132 increased protein levels of HDAC1 in cells transfected with HDAC1 but not in cells co‐transfected with HDAC1 and c‐Abl. Among class I HDACs, knockdown of endogenous c‐Abl preferentially suppressed endogenous protein levels of HDAC1, suggesting that c‐Abl stabilizes HDAC1 protein by inhibiting its proteasomal degradation. Subcellular fractionation showed that the stabilization of HDAC1 by c‐Abl occurred in the nucleus. Despite the fact that HDAC1 was phosphorylated by co‐expression with c‐Abl, stabilization of HDAC1 by c‐Abl was not affected by mutations in its sites phosphorylated by c‐Abl. Co‐expression with HDAC1 and nuclear‐targeted c‐Abl did not affect HDAC1 stabilization. Therefore, these results suggest that c‐Abl induces HDAC1 stabilization possibly through phosphorylation of a cytoplasmic target that is involved in proteasomal degradation of HDAC1.
What is needed for a theory of mobility: direct perception and cognitive maps--lessons from the blind.

A theory of mobility using nonvisual stimuli and cognitive control process is proposed to augment Gibson's (1958, 1979) explanations of visual guidance. Nonvisual processes are clearly important to the totally blind, who often manage considerable independent mobility in the absence of vision, but are also important to the sighted. Mobility can be directed by visual control stimuli in the ambient optic array, by nonvisual control stimuli, as well as by processes of spatial learning, including stimulus-response (S-R) rote learning, motor plans, schemas, and cognitive maps. The selection of processes and strategies depends on the availability of particular information or on task demands. Attentional processes select stimuli for locomotor control within any particular modality and select between perceptual and cognitive processes. The skill of traveling through the spatial environment, avoiding obstacles, and traveling directly or indirectly toward goals, is a general characteristic of animal behavior and is described here by the term mobility. Although this term has a special connotation within blindness rehabilitation (Welsh & Blasch. 1980), it is used here to describe the overall processes of guidance by which both blind and sighted travelers move through space. The study of mobility encompasses several more traditional research concerns, such as space perception, motor control, and spatial cognition. Until recently there has been little research related to general psychological theory of mobility. A comparison may be made with the study of reading, where considerable research has taken place on component tasks such as letter extraction, word recognition, and eye movements, but where there has been comparatively little interest until recently in the general rules of the process (see Haber, 1978).
Head injury and dementia

Purpose of reviewThe link between head injury and dementia/Alzheimer's disease is controversial. This review discusses some recent epidemiological, human autopsy and experimental studies on the relationship between traumatic head injury and dementia. Recent findingsRecent epidemiological studies have shown that head injury is a risk factor for the development of dementia/Alzheimer's disease, whereas others have not. After experimental brain trauma the long-term accumulation of amyloid β peptide suggests that neurodegeneration is influenced by apolipoprotein E ε4, and after human brain injury both amyloid β peptide deposition and tau pathology are seen, even in younger patients. Amyloid β peptide levels in the cerebrospinal fluid and the overproduction of β amyloid precursor protein in humans and animals after traumatic brain injury are increased. Repeated mild head trauma in both animals and humans accelerates amyloid β peptide accumulation and cognitive impairment. Retrospective autopsy data support clinical studies suggesting that severe traumatic brain injury with long-lasting morphological residuals are a risk factor for the development of dementia/Alzheimer's disease. The influence of the apolipoprotein E genotype on the prognosis of traumatic brain injury is under discussion. SummaryAlthough epidemiological studies and retrospective autopsy data provide evidence that a later cognitive decline may occur after severe traumatic brain injury, the relationship between dementia after head/brain trauma and apolipoprotein E status is still ambiguous. Both human postmortem and experimental studies showing apolipoprotein β deposition and tau pathology after head injury support the link between traumatic brain injury and dementia, and further studies are warranted to clarify this relationship.
Crystal structures of A-DNA duplexes.

All crystal structures of A-DNA duplexes exhibit a typical crystal packing, with the termini of one molecule abutting the shallow grooves of symmetry related neighbors, while all other forms (B, Z, and RNA) tend to form infinitely stacked helices. The A-DNA arrangement leads to the formation of shallow groove base multiples that have implications for the structure of DNA in compacted states. The characteristic packing leaves big solvent channels, which can be sometimes occupied by B-DNA duplexes. Comparisons of the structures of the same oligomer crystallizing in two different space groups and of different sequences crystallizing in the same space group show that the lattice forces dominate the A-DNA conformation in the crystals, complicating the effort to elucidate the influence of the base sequence on the structures. Nevertheless, in both alternating and nonalternating fragments some sequence effects can still be uncovered. Furthermore, several studies have started to define the minimal sequence changes or chemical modifications that can interconvert the oligomers between different double-helical conformers (A-, B-, and Z-form). Overall, it is seen that the rigid nucleotide principle applies to the oligomeric fragments. Besides the structures of the naked DNAs, their interactions with water, polyamines, and metal ions have attracted considerable attention. There are conserved patterns in the hydration, involving both the grooves and the backbone, which are different from those of B-DNA or Z-DNA. Overall, A-DNA seems to be more economically hydrated than B-DNA, particularly around the sugar-phosphate backbone. Spermine was found to be able to bind exclusively to either of the grooves or to the phosphate groups of the backbone, or exhibit a mixed binding mode. The located metal cations prefer binding to guanine bases and phosphate groups. The only mispairs investigated in A-DNA are the wobble pairs, yielding structural insight into their effects on helix stabilities and hydration. G.T wobble pairs have been determined in various sequence contexts, where they differentially affect the conformations and stableness of the duplexes. The structure of a G.m5C base pair, which surprisingly also adopted the wobble conformation, suggests that a similar geometry may transiently exist for G.C pairs. These results from the crystalline state will be compared to the solution state and discussed in relation to their relevance in biology.
Factors That Influence Physical Activity Participation Among High- and Low-SES Youth

Researchers have rarely addressed the relationship between socioeconomic status (SES) and physical activity fromthe perspective of youth. To illuminate the factors that youth fromlowand high-SES areas consider important to increase physical activity participation among their peers, 160 youth (12-18 years) participated in small focus group interviews. Guiding questions centered on the general theme, “If you were the one in charge of increasing the physical activity levels of kids your age, what would you do? ” Findings show that environmental factors (i.e., proximity, cost, facilities, and safety) are very important for youth living in low-SES areas to ensure participation in physical activity. Results also show that intrapersonal (i.e., perceived skill, competence, time) and social factors (i.e., friends, adult support) must be considered to help improve participation rates among both high- and low-SES youth.
Emotweet: Sentiment Analysis tool for twitter

In this 21st century, Internet is very important part of modern life. Along with Internet, OSN's also become integral part of life. OSN's provide a platform for people to share their views, ideas, information with each other irrespective of their location. By collecting this information, Sentiment Analysis can be done which helps us to gain wider public opinion about certain topic. Writer's feelings expressed in positive or negative tweets can be identified by scrutinizing large number of documents using Natural language processing and Information Extraction.
mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin

Abstract Apoptosis is a type of programmed cell death involved in many crucial biological processes. It represents the basic mechanism for the action of chemotherapeutic agents, such as doxorubicin and carboplatin. Both are able to cause cell death through the induction of apoptosis in the human leukemic cell line HL-60. We investigated the possible alterations in the expression of apoptosis-related genes, including the novel BCL2L12 gene, which was recently cloned in our group. The kinetics of apoptosis induction and cell toxicity was investigated by DNA laddering and by the MTT method, respectively. Total RNA was extracted and cDNA was prepared by reverse transcription. BCL2, BAX, FAS, caspase-9, caspase-3 and BCL2L12 were amplified by PCR. Overexpression of FAS, BCL2L12 and caspase-3 was observed after treatment of HL-60 cells for 3 or 6 h with carboplatin, while their expression was decreased after a 12-h treatment, demonstrating that these genes may take part in the early stages of apoptosis. Overexpression of the same genes was also observed after 6 h of treatment with doxorubicin (concomitantly with DNA laddering). In the case of carboplatin-induced apoptosis we detected down-regulation of BAX, BCL2 and caspase-9, whereas in the case of doxorubicin, BAX and BCL2 remained at control levels and caspase-9 was increased.
Genetic influences on measures of the environment: a systematic review

Background. Traditional models of psychiatric epidemiology often assume that the relationship between individuals and their environment is unidirectional, from environment to person. Accumulating evidence from developmental and genetic studies has made this perspective increasingly untenable. Method. Literature search using Medline, PsycINFO, article references and contact with experts to identify all papers examining the heritability of measures of environments of relevance to psychiatry/psychology. Results. We identified 55 independent studies organized into seven categories: general and specific stressful life events (SLEs), parenting as reported by child, parenting reported by parent, family environment, social support, peer interactions, and marital quality. Thirty-five environmental measures in these categories were examined by at least two studies and produced weighted heritability estimates ranging from 7% to 39%, with most falling between 15% and 35%. The weighted heritability for all environmental measures in all studies was 27%. The weighted heritability for environmental measures by rating method was: self-report 29%, informant report 26%, and direct rater or videotape observation (typically examining 10 min of behavior) 14%. Conclusion. Genetic influences on measures of the environment are pervasive in extent and modest to moderate in impact. These findings largely reflect ‘actual behavior’ rather than ‘only perceptions’. Etiologic models for psychiatric illness need to account for the non-trivial influences of genetic factors on environmental experiences.
Design of a circularly polarized reconfigurable reflectarray using micromotors

The design of an X-band circularly polarized reconfigurable reflectarray antenna is presented. Elements with concentric dual split rings are mechanically rotated by micromotors to achieve phase reconfigurability with low cross-polarization and low element loss. Simulation results show that a maximum gain of 26.43 dB with aperture efficiency of 62.9% is achieved by a reflectarray with 15×15 elements. Excellent beam scanning characteristics also validate its phase reconfigurability.
Identification of a Speaker's Sex: A Study of Vowels

An experiment was carried out to test whether three phonetically naive listeners were able to identify a speaker's sex from brief natural vowel segments. All speech segments presented to the listeners were extracted from sentences spoken by members of a group of three women and three men with a British General Northern accent. Analysis showed that listeners were able to identify the speaker's sex from the vowel segments with high accuracy (a mean score of 98.9%, P <.001). Acoustic analyses were subsequently carried out to quantify the acoustic and phonetic differences related to the sex of the speakers. Fundamental frequencies and format frequencies of the vowel stimuli were investigated. The men generally had lower values of both than the women.
Psychiatric Morbidity and Quality of Life in Children with Malignancies and Their Parents

Recent improvements in prognosis necessitate considering the emotional responses of children with malignant diseases and of their parents. This prospective study assessed 20 children and adolescents and their 36 parents within 2 weeks of diagnosis and after 1 and 6 months. Fifty-three percent exhibited moderate to severe posttraumatic symptoms right after diagnosis that decreased significantly after 1 month. Children with high-risk disease reported the most severe symptoms. Unexpectedly, children with low-risk disease exhibited more severe symptoms than those with moderate risk. Depressive symptoms decreased significantly during the period, but anxiety symptoms did not. Moreover, quality of life did not change. Twenty percent of parents exhibited posttraumatic symptoms on initial evaluation. Mothers’ symptoms did not change, but fathers’ symptoms decreased with those of their children. Several procedures and experiences were identified as causes of traumatic stress responses.
Isolation of the New Antiplasmodial Butanolide, Malleastrumolide A, from Malleastrum sp. (Meliaceae) from Madagascar

An extract of Malleastrum sp. (Meliaceae) collected in Madagascar by the Madagascar International Cooperative Biodiversity Group was found to have antimalarial activity, with an IC50 value between 2.5 and 5 μg ml−1. After purification by liquid‐liquid partition, chromatography on a Diaion open column, C18 SPE and C18 reversed phase HPLC, the new butanolide, malleastrumolide A, was isolated. The structure of malleastrumolide A was determined by mass spectrometry, NMR, and ECD. The double bond position was determined by cross‐metathesis and mass spectrometry. The compound has antiproliferative activity against the A2780 ovarian cancer cell line with an IC50 value of 17.4 μm and antiplasmodial activity against the drug‐resistant Dd2 strain of Plasmodium falciparum with an IC50 value of 2.74 μm.
Pre-process method for reducing initial bit mismatch rate in secret key generation based on wireless channel characteristics

Due to non-ideal conditions in the measurements of the channel, high initial bit mismatch rate in the secret key generation is resulted, which reduces the final secret key generation rate and even causes the secret key generation process to fail. Aiming at this problem, a pre-process method that makes the initial bit mismatch rate come down quickly is proposed in this paper. Simulation results show that the new pre-process method has excellent ability of reducing the initial b it mismatch rate, especially in the case of very high initial bit mismatch rate. The data remaining rate is improved by more than thirty-seven times when the initial bit mismatch rate is 0.3.
Role of fetal autopsy as a complementary tool to prenatal ultrasound

Abstract Aim: To correlate and compare prenatal ultrasound with fetal autopsy examination to detect structural births defects and provide specific diagnoses. Methods: 141 second trimester fetuses (<20 weeks and <500 g) where pregnancy was terminated for structural birth defects and/or severe intra-uterine growth restriction (IUGR) or intra-uterine death, referred to our tertiary care private, teaching hospital were examined by a team of experienced pathologist and clinical geneticist. Findings of pathology examination were compared to those provided by ultrasound examination. Results: A total of 301 structural abnormalities were noted. Specific etiology was identified or syndromic diagnosis was possible in 57/141 (40.4%) cases. The maximum number of systemic anomalies (45/301, 14.95%) was noted in the central nervous system (CNS). CNS anomalies were most commonly associated with facial dysmorphism including cleft lip/palate etc. There was a complete agreement between ultrasound and autopsy findings in 41/141 (29.07%) cases, additional information that did not influence the final diagnosis and/or counseling was obtained by autopsy in 65/1416 (46.09%) cases, while additional information that influenced the final diagnosis and/or counseling was provided by autopsy in 35/141 (24.82%) cases. Conclusion: Fetal autopsy serves as a complementary tool to fetal ultrasound due to its ability to pick up minor anomalies and/or anomalies that were missed on ultrasound. It may be routinely performed as an attempt to reach a specific diagnosis and offer appropriate counseling to couples, following pregnancy termination for fetal anomalies.