Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantification of actin nanoarchitecture at the T cell immunological synapse using single molecule localisation microscopy

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Milk Market Integration between Hungary and Poland

In this paper we test the retail milk price integration between two countries, Poland and Hungary. Conventional linear cointegration methods do not reveal any relationship between the two prices, therefore we apply Gonzalo and Pitakaris (2006) method to test the linear cointegration null against the threshold cointegration with an exogenous threshold variable alternative hypothesis. Our results show, that the Hungarian Forint – Polish Zloty exchange rate is econometrically an appropriate threshold variable, the linearity null is rejected, and the two alternative regimes may be characterised with different long-run equilibrium relationships. Corresponding trade data however questions the economic appropriateness of the selected threshold variable. Further research is needed to analyse the actual effective milk trade flows between the two countries, subject to exchange rate variations.
Fast approach by a multidisciplinary specialized team for atrial fibrillation compared to the standard of care in the emergency department - FAST-AF trial

Introduction : Atrial fibrillation (AF) is the most common sustained cardiac rhythm abnormality. AF treatment is provided by either cardiologists or non-cardiologists and is based on the prevention of thromboembolic events and on heart rate control or rhythm control. There is evidence that AF management by specialists leads to improved patient outcomes. Moreover, management of complex cardiac arrhythmias by a specialized team has been considered helpful by an overwhelming majority of practicing physicians. Therefore, we designed a multidisciplinary team - Fast Approach by a Specialized Team for Atrial Fibrillation (FAST-AF) - to evaluate the treatment effectiveness of a specialized arrhythmia team compared to the standard of care in the management of patients with new-onset AF presenting in the emergency department (ED). Methods: We propose an open-label, single-center, randomized, parallel group, superiority trial in an university hospital during a period of 36 months. 294 patients with new-onset AF presenting in the ED will be randomized in a 1:1 ratio to FAST-AF or standard of care. The primary outcome will be time to discharge from the beginning of the intervention. Secondary outcomes will be time to heart rate/rhythm control, compliance to anticoagulation after discharge, readmission rates, quality of life assessment (AFEQT) and hospitalization costs. For the primary analysis, an intention-to-treat (ITT) time to event (TTE) analysis will be conducted. The trial will be prospectively registered at ClinicalTrials.gov. Conclusions: AF is a prevalent disease that causes several complications and morbidity. The heterogeneity of medical criteria, the lack of knowledge of international guidelines and inadequate adherence to treatment may compromise therapeutic success. This study design is readily replicable, given its simplicity and feasibility. If the study show promising results of FAST-AF intervention, future studies can be conducted to assess cost reduction and specialized consultation by virtual meeting platforms.
Fitting and Analysis Technique for Inconsistent Nuclear Data

Consistent experiment data are crucial to adjust parameters of physics models and to determine best estimates of observables. However, often experiment data are not consistent due to unrecognized systematic errors. Standard methods of statistics such as $\chi^2$-fitting cannot deal with this case. Their predictions become doubtful and associated uncertainties too small. A human has then to figure out the problem, apply corrections to the data, and repeat the fitting procedure. This takes time and potentially costs money. Therefore, a Bayesian method is introduced to fit and analyze inconsistent experiment data. It automatically detects and resolves inconsistencies. Furthermore, it allows to extract consistent subsets from the data. Finally, it provides an overall prediction with associated uncertainties and correlations less prone to the common problem of too small uncertainties. The method is foreseen to function with a large corpus of data and hence may be used in nuclear databases to deal with inconsistencies in an automated fashion.
Dynamic risk assessment method – a proposal for assessing risk in water supply system / Metoda dynamicznego szacowania ryzyka – propozycja oceny ryzyka w systemie zaopatrzenia wody

Abstract System Dynamics is methodology for modeling and analyzing complex systems. Such systems can be characterized by interconnectedness and feedback. Applying risk assessment to the results of System Dynamics models is a challenge. Though in some cases the resulting time series data generated by a simulation may appear approximately random at a specific scale, there is often a high-degree of auto-correlation within the data series due to the deterministic nature of generation and feedback loops inherent in the system. This paper presents proposed Dynamic Risk Assessment Method (DRAM) that allows for the estimation of risk for system dynamics data series that appear to be approximately random. DRAM is based on standard risk assessment methods and is simple both to calculate and apply. In this article, the proposed method is applied to determine the risk connected with hypothetical costs of illness stemming from water supply system contamination with Cryptosporidium. Dynamika Systemów jest metodologią modelowania i analizy złożonych systemów. Taki złożony system może być charakteryzowany przez wzajemne proste połączenia elementów oraz istniejące sprzężenia zwrotne. Przeprowadzenie oceny ryzyka przy modelowaniu Systemów Dynamicznych jest trudnym wyzwaniem. Chociaż w niektórych przypadkach, uzyskane za pomocą symulacji serie wyników mogą się wydawać przypadkowe, to jednak często istnieje wysoki stopień autokorelacji między tymi seriami wynikający z istnienia powiązań zwrotnych w systemie. Artykuł przedstawia propozycje Metody Dynamicznego Szacowania Ryzyka (MDSR), która pozwala oceniać ryzyko związane z hipotetycznymi kosztami zachorowań wywołanymi skażeniem systemu zaopatrzenia w wodę przez Cryptosporidium.
Interactive comment on “ Modeling impacts of farming management practices on greenhouse gas emissions in the oasis region of China ” by Y

To REVIEWER #2: General comments: This paper tests the DNDC model only by comparing the one year measured and simulated values of CO2 and N2O fluxes. However, for the validation of the biogeochemical model as DNDC, more comparisons should be provided. Comparisons between the measured data and model output parameters such as carbon/nitrogen content in soil and plants, soil temperature and soil water content should also be provided to verify the applicability of the model. The limitation of the DNDC model should be addressed. The text contains numerous minor problems, with respect to syntax, word usage, and other grammatical issues. There are several other points that need to be addressed. ResponseïijŽThanks for your kind words. We agreed. There was a significant correlation between modeled and observed daily N2O and CO2 emission fluxes under conditions of four different fertilizing, the coefficients of determination (R2) ranging from 0.62 to 0.82 for N2O and from 0.70 to 0.78 for CO2, and the relative deviations were about 45% for N2O and 25% for CO2ïijŇrespectively. The results suggest that the N2O and CO2 emissions can be well modeled by DNDC. The relationship between observed and modeled the nitrate (NO3-) for the top 10 cm of the soil profile in summer maize fields are shown in Figure 1 in the following or in Figure 4 (please see page 27 in the revised manuscript) in the revised manuscript, and the relative deviations are about 40%. The results further support the acceptability of the DNDC model. The DNDC model captures the main peak emissions of N2O, which are well matched with field observations in discharge time.
Does biodiversity of estuarine phytoplankton depend on hydrology ?

Phytoplankton growth in estuaries is controlled by factors such as flushing, salinity tolerance, light, nutrients and grazing. Here, we show that biodiversity of estuarine phytoplankton is related to flushing, and illustrate this for some European estuaries. The implications for the definition of reference conditions for quality elements in estuaries of different types are examined, leading to the conclusion that constraints on the number of estuarine and coastal types that may be defined for management ningful. different iversity. ay interact s harmful
GRB 081007 AND GRB 090424: THE SURROUNDING MEDIUM, OUTFLOWS, AND SUPERNOVAE

We discuss the results of the analysis of multi-wavelength data for the afterglows of GRB 081007 and GRB 090424, two bursts detected by Swift. One of them, GRB 081007, also shows a spectroscopically confirmed supernova, SN 2008hw, which resembles SN 1998bw in its absorption features, while the maximum magnitude may be fainter, up to 0.7 mag, than observed in SN 1998bw. Bright optical flashes have been detected in both events, which allows us to derive solid constraints on the circumburst-matter density profile. This is particularly interesting in the case of GRB 081007, whose afterglow is found to be propagating into a constant-density medium, yielding yet another example of a gamma-ray burst (GRB) clearly associated with a massive-star progenitor which did not sculpt the surroundings with its stellar wind. There is no supernova component detected in the afterglow of GRB 090424, likely due to the brightness of the host galaxy, comparable to the Milky Way. We show that the afterglow data are consistent with the presence of both forward- and reverse-shock emission powered by relativistic outflows expanding into the interstellar medium. The absence of optical peaks due to the forward shock strongly suggests that the reverse-shock regions should be mildly magnetized. The initial Lorentz factor of outflow of GRB 081007 is estimated to be Γ ∼ 200, while for GRB 090424 a lower limit of Γ > 170 is derived. We also discuss the prompt emission of GRB 081007, which consists of just a single pulse. We argue that neither the external forward-shock model nor the shock-breakout model can account for the prompt emission data and suggest that the single-pulse-like prompt emission may be due to magnetic energy dissipation of a Poynting-flux-dominated outflow or to a dissipative photosphere.
Soil biodiversity and environmental change in European forests

Abstract Biodiversity not only responds to environmental change, but has been shown to be one of the key drivers of ecosystem function and service delivery. Forest soil biodiversity is also governed by these principles, the structure of soil biological communities is clearly determined by spatial, temporal and hierarchical factors. Global environmental change, together with land-use change and forest ecosystem management, impacts the aboveground structure and composition of European forests. Due to the close link between the above- and belowground parts of forest ecosystems, we know that soil biodiversity is also impacted. However, very little is known about the nature of these impacts; effects they have on the overall level of biodiversity, the functions it fulfills, and on the future stability of forests and forest soils. Even though much remains to be learned about the relationships between soil biodiversity and forest ecosystem functionality, it is clear that better effort needs to be made to preserve existing soil biodiversity and forest conservation strategies taking soils into account must be considered.
Connection to Nature

A connection to nature index was developed and tested to measure children’s affective attitude toward the natural environment. The index was employed through a survey that investigates students’ attitude toward Lagoon Quest, a mandatory environmental education program for all fourth-grade, public school students in Brevard County, Florida. Factor analyses were conducted to explore and confirm different factors in the connection to nature index. A path analysis was conducted to examine the association among variables. The results suggest four dimensions in the children’s connection to nature index: (a) enjoyment of nature, (b) empathy for creatures, (c) sense of oneness, and (d) sense of responsibility. Children’s connection to nature influences their intention to participate in nature-based activities in the future. Children’s connection to nature, their previous experience in nature, their perceived family value toward nature, and their perceived control positively influenced their interest in performing environmentally friendly behaviors.
Seafloor spreading evolution in response to continental growth

The growth of the continental crust has shaped the evolution of the Earth from its interior to its fluid envelopes. Continents have played a major role in the evolution of global tectonics through their interaction with mantle convection. The feedback between continents and mantle convection has been studied for the past 25 years, but it is only recently that the dynamic influence of continents on seafloor spreading can be explored thanks to progress in convection modeling. In this work, we investigate how continental size impacts seafloor spreading activity with state-of-the-art three-dimensional spherical convection models. We show that increasing the continental area forces higher production rates of new seafloor with stronger fluctuations. As a consequence, the average age of the seafloor decreases with increasing continental area. This study suggests that mantle heat loss experienced significant fluctuations through continental growth and reinforces the estimate of
The Role of Self-Accumulated Peptide Amphiphile in Spinal Cord Injury Functional Reclamation

Injection into an experimentally injured spinal cord of a self-assembling peptide amphiphile (PA) that displays an IKVAV epitope reduced glial scarring and improved functional reclamation (Tysseling-Mattiace et al., 2008). Injection of a material that lacked this epitope did not alter outcome suggesting that signaling by the IKVAV epitope was central to the beneficial effects of IKVAV-PA. However the mechanical properties of implanted materials may also alter tissue and cell behavior in vivo (Discher et al., 2005). We therefore explored whether the mechanical properties of PAs might affect outcome after spinal cord injury. By treating animals with a spinal cord injury with different PAs that varied in their mechanical properties without epitope presentation, we found that the beneficial effects of the PAs are primarily dependent upon the presentation of a bioactive epitope presentation rather than the mechanical properties of the PA scaffold.
An integrated Earth sensing sensorweb for improved crop and rangeland yield predictions

This paper outlines research and development towards an integrated Earth sensing sensorweb system for improved crop and rangeland yield predictions. The paper introduces the concepts of integrated Earth sensing and in situ sensorwebs and describes the key aspects and innovations of an intelligent sensorweb for integrated Earth sensing (ISIES). ISIES incorporates a sensorweb that provides automatic and continuous in situ measurements and advanced crop growth models and leading-edge sensorweb-enabled OpenGIS-compliant Web services. A key component of each in situ sensorweb node is SmartCore, a compact device developed to control sensor data traffic autonomously and to communicate wirelessly in two-way mode with the ISIES central server. The system server automatically integrates the in situ sensorweb data with remote sensing data and crop models to provide maps of leaf area index and soil moisture and biomass and improved predictions of crop and rangeland yield.
The Criminology of Cyber Stalking: Investigating the Crime, Offenders and Victims of Cyber Stalking

Understanding the elements and parties of each offense, including the offender and the victim, is the first step to tackle a crime. Cyber stalking is one of the most widespread crimes in the cyberspace. Despite substantial similarities between traditional harassment and cyber stalking, there are some diversities between these two forms of crime in terms of perpetration and their instances. These differences have caused cyber stalking to be doubly harmful compared to its traditional style. Emails, chat rooms, online social networking include tools and platforms for perpetration of this offense. The findings of this study suggest that most perpetrators of this crime are male and most victims are women. The most significant reason of this can be due to poor performance of criminalization process. Therefore, it is recommended that criminal legislation applies differential approaches and more severe penalties against cybercrimes against women in the cyberspace. Language: en
Creating large second-order optical nonlinearity in optical waveguides written by femtosecond laser pulses in boro-aluminosilicate glass

The thermal poling technique was applied to optical waveguides embedded in a commercial boro-aluminosilicate glass, resulting in high levels of induced second-order optical nonlinearity. The waveguides were fabricated using the femtosecond laser direct-write technique, and thermally poled samples were characterized with second harmonic optical microscopy to reveal the distribution profile of the induced nonlinearity. It was found that, in contrast to fused silica, the presence of waveguides in boro-aluminosilicate glass led to an enhancement of the creation of the second-order nonlinearity, which is larger in the laser written waveguiding regions when compared to the un-modified substrate. The magnitude of the nonlinear coefficient d33 achieved in the core of the laser-written waveguides, up to 0.2 pm/V, was comparable to that in thermally poled fused silica, enabling the realization of compact integrated electro-optic devices in boro-aluminosilicate glasses.
FOXP3 Modulation of Quercetin-3-O-rhamnoside and its Impacts on Lupus Nephritis Mice

Background: Quercetin-3-O-rhamnoside (QUE) has anti-inflammatory and anti-oxidative effects which probably beneficially used in lupus. Objective: This research was focused on analyzing the effects of QUE on FOXP3 modulation to result in an anti-inflammatory outcome in the kidney of severe lupus mice. Methods: This research used Pristane-induced female BALB/c lupus mice, and the biomarkers involved in were CD4+CD25+ T reg cells, FOXP3 T cells, anti-Sm, IL-6, and histopathology assessment of the kidney of lupus mice. The QUE group was treated and compared to the negative control which received placebo, and the positive control which received cyclophosphamide. Results: QUE increased the number of CD4+CD25+ T reg cells (negative control: 3.01±3.43%; QUE: 18.77±5.12%; positive control: 3.26±11.09%), and FOXP3 significantly (p Key words: Glomerulonephritis, IL-6, Lupus, Pristane, T regs.
Jurnal Teknologi Detecting SIM Box Fraud by Using Support Vector Machine and Artificial Neural Network

Fraud in communication has been increasing dramatically due to the new modern technologies and the global superhighways of communication, resulting in loss of revenues and quality of service in telecommunication providers especially in Africa and Asia. One of the dominant types of fraud is SIM box bypass fraud whereby SIM cards are used to channel national and multinational calls away from mobile operators and deliver as local calls. Therefore it is important to find techniques that can detect this type of fraud efficiently. In this paper, two classification techniques, Artificial Neural Network (ANN) and Support Vector Machine (SVM) were developed to detect this type of fraud. The classification uses nine selected features of data extracted from Customer Database Record. The performance of ANN is compared with SVM to find which model gives the best performance. From the experiments, it is found that SVM model gives higher accuracy compared to ANN by giving the classification accuracy of 99.06% compared with ANN model, 98.71% accuracy. Besides, better accuracy performance, SVM also requires less computational time compared to ANN since it takes lesser amount of time in model building and training.
Mortality Rate and Survival of Pigs Classified by Immune Response Phenotype Using the High Immune Response Technology

Ontario Veterinary College, University of Guelph, Department of Pathobiology, 50 Stone Rd. E. , N1G 2W1, Guelph, Canada jschmied@uoguelph.ca (Corresponding Author) 2 Iowa State University, Ames, USA University of Alberta, Edmonton, Canada Centre de Développement du Porc du Québec, Québec City, Canada 5University of Saskatchewan, Saskatoon, Canada PigGen Canada, Guelph, Canada Centre for the Genetic Improvement of Livestock
Individual responses of growing pigs to threonine intake

ABSTRACT A nitrogen balance test was performed to evaluate the individual responses of growing pigs to threonine intake. Eight commercial barrows were used (body weight ranging from 15 to 20 kg). A dose-response study was performed, in which the threonine supply increased in seven equidistant steps (the seven dietary threonine levels ranged from 50 to 120% of the requirements) every three days for each pig. The levels of all other amino acids were 20% higher than the tested amino acid. [. ]
K + channels in biological processes: vascular K + channels in the regulation of blood pressure

: Appropriate supply of blood to organs and tissues is highly dependent on arterial blood pressure and therein of the peripheral blood vessel resistance. Of the two main components of vessel resistance, the active resistance results from the modulation of the contractility level of vascular smooth muscle cells (VSMCs). The intracellular level of Ca 2 + in VSMCs is an essential component of muscle contraction and is tightly regulated through modulation of the membrane potential. Since resting membrane potential of vascular cells is mainly dependent on K + ions, ion channels permeable to K + ions have a significant impact on contractility of smooth muscle cells and therefore on vascular diameter and blood pressure. Activation of K + channels on both endothelial cells and VSMCs is generally associated to hyperpolarization and relaxation of vascular smooth muscle. Several types of K + channels are expressed in VSMCs and endothelial cells, and they are classified based on their pharmacological and biophysical properties. Voltage-dependent K + channels are activated by depolarization and are mainly involved in negative-feedback mechanisms. Ca 2 + -activated K + channels can be divided into three groups, with BK Ca being activated by both intracellular Ca 2 + and depolarization. On the other hand, K Ca 2.x and K Ca 3.1 channels (small and intermediate Ca 2 + -activated K + channels, respectively) are almost strictly dependent on rises in intracellular Ca 2 + levels to increase their open probability. K ir and adenosine triphosphate (ATP)-sensitive K + (K ATP ) channels, members of the same family, have a significant impact on VSMC membrane potential. The more recently studied two-pore K + channels are thought to be metabolic sensors (like K ATP channels) and would be involved in acute regulation of local blood flow. This review will summarize the main K + channels expressed in vascular cells and their relevance in the control of vascular tone and blood pressure.