Miracle-dz/UniFAR-FTUs huggingface dataset:
Subjective correlates of stress management in outpatient cardiac rehabilitation: the predictive role of perceived heart risk factors

Introduction: The causal attributions and perceived risk factors can affect patients’ health behaviors. Therefore, the present study aimed to assess (i) the effect of an outpatient cardiac rehabilitation (CR) program on perceived heart risk factors (PHRFs) and on psychological stress, and (ii) the role of changes of PHRFs at pre-post CR in predicting changes in psychological stress. Methods: In this longitudinal study, 110 CR patients were assessed from June to November 2016 in a hospital in Iran. Perceived heart risk factors and perceived stress were investigated using the PHRFs scale and the Depression, Anxiety, Stress Scale-21, respectively. PHRFs and DASS-21 Stress scale scores were compared before and after 26 sessions of exercise-based CR through paired sample t-tests. In addition, we investigated the effect of PHRF’s change scores on DASS-21 Stress scale scores using linear regression analysis. Results: Results showed that CR has a little impact in improving the patients’ perception of heart risk factors, However, CR is significantly effective in reducing stress (P < 0.05). Regression analysis evidenced that improvements in patients’ perception of risk factors can significantly predict a reduction in psychological stress (P = 0.030). The model explained 11.2% of the variance in the results. Conclusion: PHRFs appear to be significant predictive components of CR’s stress reduction. Practitioners should focus on patients’ perception of risk factors to facilitate stress management in CR program.
A Novel Self-Adaptive VM Consolidation Strategy Using Dynamic Multi-Thresholds in IaaS Clouds

With the rapid development of cloud computing, the demand for infrastructure resources in cloud data centers has further increased, which has already led to enormous amounts of energy costs. Virtual machine (VM) consolidation as one of the important techniques in Infrastructure as a Service clouds (IaaS) can help resolve energy consumption by reducing the number of active physical machines (PMs). However, the necessity of considering energy-efficiency and the obligation of providing high quality of service (QoS) to customers is a trade-off, as aggressive consolidation may lead to performance degradation. Moreover, most of the existing works of threshold-based VM consolidation strategy are mainly focused on single CPU utilization, although the resource request on different VMs are very diverse. This paper proposes a novel self-adaptive VM consolidation strategy based on dynamic multi-thresholds (DMT) for PM selection, which can be dynamically adjusted by considering future utilization on multi-dimensional resources of CPU, RAM and Bandwidth. Besides, the VM selection and placement algorithm of VM consolidation are also improved by utilizing each multi-dimensional parameter in DMT. The experiments show that our proposed strategy has a better performance than other strategies, not only in high QoS but also in less energy consumption. In addition, the advantage of its reduction on the number of active hosts is much more obvious, especially when it is under extreme workloads.
Factors associated with committed participation in a wellness-walking program for people with lower limb loss: A prospective cohort study

Background: Wellness activities can benefit health, yet committed adherence is challenging. Objectives: Identify factors associated with committed participation in an amputee wellness-walking program and determine benefits of committed participation. Study design: Prospective longitudinal cohort. Methods: Two former Paralympians led the wellness-walking sessions. Participants provided medical history and self-reported balance confidence and prosthetic functional measures. Physiotherapy professionals/paraprofessionals assessed balance and gait. Committed participants—those attending three sessions within 3 years—were compared to one-time-only participants using Fisher’s exact and independent t-tests. First and third sessions for committed participants were compared with t-tests. A bootstrapped multivariable logistic regression model was developed using significant univariate predictors. Results: A total of 305 volunteers averaged 55.7 ± 15.2 years, including 68.4% men, 78.4% White race; 51.8% with dysvascular amputations, 40.5% with ⩾1 prosthetic knee; and 49.1% independent community walkers. Committed participants were initially similar to one-time-only participants (p > 0.05) except for fewer years since amputation (p = 0.007), better balance ability (p = 0.001), and greater likelihood of dieting (p = 0.030). The final model—balance ability (odds ratio = 2.4), dieting (odds ratio = 3.3), and years since amputation (odds ratio = 0.94)—identified 88.0% of committed participants (p = 0.007). Balance confidence and functional improvements after three sessions were not significant (p > 0.07). Conclusion: Committed participants were more likely to diet, have better balance ability, and have more recent amputations than one-time-only participants. Clinical relevance Knowing which characteristics identify people most likely to become committed participants—such as people with recent amputations, an interest in dieting, and better balance ability—may help health practitioners from different professions promote consistent participation in wellness activities that may benefit self-reported function.
Author Profiling for Abuse Detection

The rapid growth of social media in recent years has fed into some highly undesirable phenomena such as proliferation of hateful and offensive language on the Internet. Previous research suggests that such abusive content tends to come from users who share a set of common stereotypes and form communities around them. The current state-of-the-art approaches to abuse detection are oblivious to user and community information and rely entirely on textual (i.e., lexical and semantic) cues. In this paper, we propose a novel approach to this problem that incorporates community-based profiling features of Twitter users. Experimenting with a dataset of 16k tweets, we show that our methods significantly outperform the current state of the art in abuse detection. Further, we conduct a qualitative analysis of model characteristics. We release our code, pre-trained models and all the resources used in the public domain.
Quantifying training challenges of dependency parsers

Not all dependencies are equal when training a dependency parser: some are straightforward enough to be learned with only a sample of data, others embed more complexity. This work introduces a series of metrics to quantify those differences, and thereby to expose the shortcomings of various parsing algorithms and strategies. Apart from a more thorough comparison of parsing systems, these new tools also prove useful for characterizing the information conveyed by cross-lingual parsers, in a quantitative but still interpretable way.
Silencing of casein kinase 1 delta reduces migration and metastasis of triple negative breast cancer cells

The casein kinase 1 delta (CSNK1D) is a conserved serine/threonine protein kinase that regulates diverse cellular processes including cell cycle progression, circadian rhythm, and neurite outgrowth. Aberrant expression of CSNK1D is described in several cancer types including breast cancer, where it is amplified in about 30% of triple negative breast (TNBC). Here, we have investigated the function of CSNK1D in triple negative cancer cell migration and metastasis. By using immunohistochemistry and in situ hybridization, we found that CNSK1D is highly expressed in primary tumor cells and in tumor cells invading lymphatic nodes compared to non-metastatic tumors. In vitro, knock-down of CSNK1D expression with specific shRNAs in the breast cancer cell line MDA-MB-231 markedly inhibited cancer cell proliferation, invasion and migration and affected the expression of the tight junction proteins claudin 1, occludin and the junction adhesion molecule A. In vivo, the inactivation of CSNK1D reduced lung metastasis in MDA-MB-231 breast cancer xenografts. Altogether, our results indicate that the downregulation of CSNK1D expression inhibits the proliferation and reduces the migration and the metastasis of breast cancer cells. As numerous inhibitors of CSNK1D are currently under development, this might represent an attractive therapeutic target for the treatment of TNBC.
A Simple Separation Method of the Protein and Polystyrene Bead-Labeled Protein for Enhancing the Performance of Fluorescent Sensor

Dielectrophoresis- (DEP-) based separation method between a protein, amyloid beta 42, and polystyrene (PS) beads in different microholes was demonstrated for enhancement of performance for bead-based fluorescent sensor. An intensity of ∇|E|2 was relative to a diameter of a microhole, and the diameters of two microholes for separation between the protein and PS beads were simulated to 3 μm and 15 μm, respectively. The microholes were fabricated by microelectromechanical systems (MEMS). The separation between the protein and the PS beads was demonstrated by comparing the average intensity of fluorescence (AIF) by each molecule. Relative AIF was measured in various applying voltage and time conditions, and the conditions for allocating the PS beads into 15 μm hole were optimized at 80 mV and 15 min, respectively. In the optimized condition, the relative AIF was observed approximately 4.908 ± 0.299. Finally, in 3 μm and 15 μm hole, the AIFs were approximately 3.143 and −1.346 by 2 nm of protein and about −2.515 and 4.211 by 30 nm of the PS beads, respectively. The results showed that 2 nm of the protein and 30 nm of PS beads were separated by DEP force in each microhole effectively, and that our method is applicable as a new method to verify an efficiency of the labeling for bead-based fluorescent sensor ∇|E|2.
An approach for controlling the timing and order of engineered mutations in mice

Significant advances in our understanding of normal development and disease have been facilitated by engineered mice in which genes can be altered in a spatially, temporally, or cell type restricted manner using site specific recombinase systems like Cre‐loxP or Flp‐frt. In many circumstances it is important to understand how interactions between multiple genes influence a given phenotype. Robust approaches for precisely controlling multiple genetic alterations independently are limited, however, thus the impact of mutation order and timing on phenotype is generally unknown. Here we describe and validate a novel Gt(ROSA)26Sor targeted transgene allowing precise control over the order and timing of multiple genetic mutations in the mouse. The transgene expresses an optimized, Flp‐estrogen receptor fusion protein (Flpo‐ERT2) under the control of a loxP‐stop‐loxP cassette. In this system, genes modified by loxP sites are altered first upon expression of Cre. Cre also eliminates the loxP‐stop‐loxP cassette, permitting widespread expression of Flpo‐ERT2. Because of the estrogen receptor fusion, Flp activity remains inert until administration of tamoxifen, allowing genes modified by frt sites to be modified subsequently with controllable timing. This mouse transgene will be useful in a wide variety of applications where independent control of different mutations in the mouse is desirable.
MicroRNAs as Urinary Biomarker for Oncocytoma

The identification of benign renal oncocytoma, its differentiation from malignant renal tumors, and their eosinophilic variants are a continuous challenge, influencing preoperative planning and being an unnecessary stress factor for patients. Regressive changes enhance the diagnostic dilemma, making evaluations by frozen sections or by immunohistology (on biopsies) unreliable. MicroRNAs (miRs) have been proposed as novel biomarkers to differentiate renal tumor subtypes. However, their value as a diagnostic biomarker of oncocytoma in urines based on mechanisms known in oncocytomas has not been exploited. We used urines from patients with renal tumors (oncocytoma, renal cell carcinoma: clear cell, papillary, chromophobe) and with other urogenital lesions. miRs were extracted and detected via qRT-PCR, the respective tumors analyzed by immunohistology. We found isocitrate dehydrogenase 2 upregulated in oncocytoma and oncocytic chromophobe carcinoma, indicating an increased Krebs cycle metabolism. Since we had shown that all renal tumors are stimulated by endothelin-1, we analyzed miRs preidentified by microarray after endothelin-1 stimulation of renal epithelial cells. Four miRs are proposed as presurgical urinary biomarkers due to their known regulatory mechanism in oncocytoma: miR-498 (formation of the oncocytoma-specific slice-form of vimentin, Vim3), miR-183 (associated with increased CO2 levels), miR-205, and miR-31 (signaling through downregulation of PKC epsilon, shown previously).
Exploiting Syntactic Structures for Humor Recognition

Humor recognition is an interesting and challenging task in natural language processing. This paper proposes to exploit syntactic structure features to enhance humor recognition. Our method achieves significant improvements compared with humor theory driven baselines. We found that some syntactic structure features consistently correlate with humor, which indicate interesting linguistic phenomena. Both the experimental results and the analysis demonstrate that humor can be viewed as a kind of style and content independent syntactic structures can help identify humor and have good interpretability.
Correcting Chinese Word Usage Errors for Learning Chinese as a Second Language

With more and more people around the world learning Chinese as a second language, the need of Chinese error correction tools is increasing. In the HSK dynamic composition corpus, word usage error (WUE) is the most common error type. In this paper, we build a neural network model that considers both target erroneous token and context to generate a correction vector and compare it against a candidate vocabulary to propose suitable corrections. To deal with potential alternative corrections, the top five proposed candidates are judged by native Chinese speakers. For more than 91% of the cases, our system can propose at least one acceptable correction within a list of five candidates. To the best of our knowledge, this is the first research addressing general-type Chinese WUE correction. Our system can help non-native Chinese learners revise their sentences by themselves.
Chicken fillets subjected to UV‐C and pulsed UV light: Reduction of pathogenic and spoilage bacteria, and changes in sensory quality

Abstract We have compared the efficacy of continuous ultraviolet (UV‐C) (254 nm) and pulsed UV light in reducing the viability of Salmonella Enteritidis, Listeria monocytogenes, Staphylococcus aureus, enterohemorrhagic Escherichia coli, Pseudomonas spp. , Brochothrix thermospacta, Carnobacterium divergens, and extended‐spectrum β‐lactamase producing E. coli inoculated on chicken fillet surface. Fluences from 0.05 to 3.0 J/cm2 (10 mW/cm2, from 5 to 300 s) used for UV‐C light resulted in average reductions from 1.1 to 2.8 log cfu/cm2. For pulsed UV light, fluences from 1.25 to 18.0 J/cm2 gave average reductions from 0.9 to 3.0 log cfu/cm2. A small change in the odor characterized as sunburnt and increased concentration of volatile compounds associated with burnt odor posed restrictions on the upper limit of UV treatment, however no sensory changes were observed after cooking the meat. Treatments under modified atmosphere conditions using a UV permeable top film gave similar or slightly lower bacterial reductions. Practical applications Ultraviolet (UV) light may be used for decontaminating the surface of food products and reduce viability of pathogenic and spoilage bacteria. Exposure of raw chicken fillet surface to various doses of continuous UV‐C or pulsed UV light proposed in the present work represent alternatives for microbiological improvement of this product. Chicken fillets can be treated in intact packages covered with UV permeable top film, thus avoiding recontamination of the meat. UV‐C light treatment is a low cost strategy with low maintenance, whereas pulsed UV light involves more elaborate equipment, but treatment times are short and less space is required. Both methods can be helpful for producers to manage the safety and quality of chicken fillets.
Paediatric intensive care and neonatal intensive care airway management in the United Kingdom: the PIC‐NIC survey

In 2011, the Fourth National Audit Project (NAP4) reported high rates of airway complications in adult intensive care units (ICUs), including death or brain injury, and recommended preparation for airway difficulty, immediately available difficult airway equipment and routine use of waveform capnography monitoring. More than 80% of UK adult intensive care units have subsequently changed practice. Undetected oesophageal intubation has recently been listed as a ‘Never Event’ in UK practice, with capnography mandated. We investigated whether the NAP4 recommendations have been embedded into paediatric and neonatal intensive care practice by conducting a telephone survey of senior medical or nursing staff in UK paediatric intensive care units (PICUs) and neonatal intensive care units (NICUs). Response rates were 100% for paediatric intensive care units and 90% for neonatal intensive care units. A difficult airway policy existed in 67% of paediatric intensive care units and in 40% of neonatal intensive care units; a pre‐intubation checklist was used in 70% of paediatric intensive care units and in 42% of neonatal intensive care units; a difficult intubation trolley was present in 96% of paediatric intensive care units and in 50% of neonatal intensive care units; a videolaryngoscope was available in 55% of paediatric intensive care units and in 29% of neonatal intensive care units; capnography was ‘available’ in 100% of paediatric intensive care units and in 46% of neonatal intensive care units, and ‘always available’ in 100% of paediatric intensive care units and in 18% of neonatal intensive care units. Death or serious harm occurring secondary to complications of airway management in the last 5 years was reported in 19% of paediatric intensive care units and in 26% of neonatal intensive care units. We conclude that major gaps in optimal airway management provision exist in UK paediatric intensive care units and especially in UK neonatal intensive care units. Wider implementation of waveform capnography is necessary to ensure compliance with the new ‘Never Event’ and has the potential to improve airway management.
High-stakes information: Deciding what constitutes quality in our products of communication

As more information is digitized or born online, issues with assessment and preservation, in the forms of determining, reviewing, and describing it, increase. This is particularly true for what we might term high-stakes information, or information that if not carefully assessed or preserved can result in harmful consequences. With the premise that scholarly information is high-stakes information, the panel will take a tripartite approach to the consideration of what constitutes information quality in three distinct contexts: quality as an element of the research process, quality as a component of the scholarly communication process, and quality as a factor in the storage and long-term access of the product of research. The researchers on this panel will present reviews of the literature and their research findings. After the presentations, the panelists will raise a series of questions in order to foster discussion with the audience.
Protective Effects of Miswak (Salvadora persica) against Experimentally Induced Gastric Ulcers in Rats

Gastric ulcers are among the most broadly perceived illnesses affecting individuals. Alcohol consumption is the main cause of gastric ulceration. This study assessed the protective effects of Salvadora persica (SP) extract against ethanol-induced gastric ulcer and elucidated the conceivable underlying mechanisms involved. For this purpose, 40 rats were allotted into 4 equal groups (control, ethanol- (EtOH-) treated, and SP-treated “SP200 and SP400” groups). The control and EtOH-treated groups were given phosphate buffer saline (PBS), and both the SP200 and SP400 groups were given SP extract dissolved in PBS at doses of 200 and 400 mg/kg b.w. , respectively. All treatments were given orally for 7 constitutive days. On the 8th day, all rats were fasted for 24 h followed by oral gavage of PBS in the control group and chilled absolute ethanol solution (5 ml/kg b.w.) in the EtOH- and SP-treated groups to induce gastric lesions. One hour later, the rats were sacrificed and the stomachs were harvested. Gross and microscopic examinations of the EtOH-treated group showed severe gastric hemorrhagic necrosis, submucosal edema, destruction of epithelial cells, and reduced glycoprotein content at the mucus surface. These pathological lesions were defeated by SP extract treatment. Administration of SP extract modulated the oxidative stress and augmented the antioxidant defenses. The elevated ethanol-expressed tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) genes, as well as bcl-2-like protein 4 (Bax) and inducible nitric oxide synthase (iNOS), were diminished in the SP-treated group. Curiously, SP extract upregulated endothelial nitric oxide synthase (eNOS) and transforming growth factor-β1 (TGF-β1) gene expression comparable to that of the EtOH-treated rats. Aggregately, SP exerted antiulcer activities in ethanol-induced gastric ulcer rat models via modulation of oxidant/antioxidant status, mitigation of proinflammatory cytokines, and apoptosis, as well as remodeling of both NOS isoforms.
Factors Associated with Resolution of Hypertension after Adrenalectomy in Patients with Primary Aldosteronism

Background The aim of this study was to investigate the factors associated with resolution of hypertension after adrenalectomy in patients with primary aldosteronism. A secondary aim was to describe our use of the contralateral ratio in adrenal venous sampling (AVS) in the setting of suboptimal successful cannulation rates. Methods A retrospective review of patients who underwent AVS followed by unilateral adrenalectomy for primary aldosteronism was performed. Results Complete resolution of hypertension and hypokalemia was seen in 17 of 40 patients (42.5%), while a clinical improvement in hypertension was seen in 38 of 40 (95%). Shorter duration of hypertension, mean aldosteronoma resolution score (ARS), and a high ARS of 3 to 5 were associated with resolution of hypertension after adrenalectomy (P=0.02, P=0.02, and P=0.004, respectively). Of the individual components of ARS, only a duration of hypertension of ≤6 years was associated with resolution of hypertension after adrenalectomy (P=0.03). Conclusion A shorter duration of hypertension was significantly associated with resolution of hypertension after adrenalectomy in patients with primary aldosteronism.