Miracle-dz/UniFAR-FTUs huggingface dataset:
CARACTERIZAÇÃO E AVALIAÇÃO DO COMPORTAMENTO TÉRMICO DOS MEDICAMENTOS DE REFERÊNCIA, GENÉRICO E SIMILAR CONTENDO O ÁCIDO ACETIL SALICÍLICO COMO PRINCÍPIO ATIVO

O presente estudo utilizou as tecnicas termoanaliticas (TG, DTG e DSC) para avaliar o comportamento termico de medicamentos a base de acido acetil salicilico comercializados como referencia, generico e similar. As amostras foram tambem caracterizadas por IV e DRX. As curvas TG/DTG mostraram comportamentos semelhantes, sendo verificado, algumas variacoes, devido a presenca dos excipientes nas formulacoes farmaceuticas. As curvas DSC apresentaram um pico endotermico caracteristico da fusao do acido acetil salicilico em todas as amostras. Os difratogramas de raios X mostraram similaridades, caracterizando as amostras como cristalinas.
Transport of antibiotics and metabolite analogs by systems under cyclic AMP control: positive selection of Salmonella typhimurium cya and crp mutants

Mutants in the cyclic AMP (cAMP) control system in Salmonella typhimurium (cya = adenyl cyclase, crp = cAMP receptor protein) were partially resistant to growth inhibition by 22 antibiotics (including fosfomycin, nalidixic acid, and streptomycin) and 29 inhibitory analogs of normal bacterial fuel/carbon sources. This resistance was used as the basis for an efficient positive selection of cya and crp mutants. We propose that these antibiotics and analogs enter the bacteria through transport systems normally used for transporting fuel/carbon sources and that this is accomplished because of a structural similarity between the antibiotic and the natural substrate of the particular transport system involved. We propose that these transport systems are all under positive control by cAMP and that cAMP acts as a signal molecule (alarmone) for fuel/carbon deprivation. Evidence is provided for a hierarchy within operons controlled by cAMP. The methodology is shown to be useful for analyzing both antibiotic transport systems and the cAMP super-control system.
Future Technologies: The Matter of Emergent Ethical Issues in Their Development

Ethical issues in technologies are usually identifiedwhen a technology has already been developed. Littleconsideration is given to ethical issues as they emerge fromtechnologies being developed. This can be disadvantageous on a number of fronts, not least because an opportunity to avoid or correct any pitfalls as future technologies and applications come to life could have been avoided. Needless to say, a better understanding of ethical issues as future technologies emerge can be beneficial to influencing the design and eventual implementation of future technologies. Arguably, projecting any future, let alone that of technologies is challenging. However, borne out of a project with a mandate to look at emerging technologies and ethical issues in ICT applications (ETICA)especially in Europe, this paper outlines how the ETICA project has began carrying out this mandate by initially developing a conceptual framework of future technologies with a view tooutlining subsequent emerging ethical issues. This outline is undertaken by looking at likely future technological developments that are expected to materialise in the next 10 to 15 years in Europe. Although a European landscape and perspective offers a starting point in projecting future technologies and their ethical issues, the ETICA project hopes that its findings will resonate to some degree at a global level where good practice might be learnt and shared because future technologies and their ethical issues willno doubt be cross-cutting just as present and already existing technologies are. This paper and ETICA’s work is relevant for the conference because it not only aims to discuss likely future technological development but goes a step further to look at the subsequent ethical issues that are likely to arise as well. The awareness of ethical issues as future technologies are being developed is equally important because developers become alert and sensitive to users needs not only as they plan the technologies but also during the process of development right up to implementation. Such awareness has the potential to avoid or lessen major ethical pitfalls when a technology is fully developed and in operation.
A HIDDEN MARKOV MODEL FOR LATENT TEMPORAL CLUSTERING

We present a new partition-valued Markov chain for modeling latent temporal clustering. The family of Markov chains we consider satisfies notable statistical properties, including exchangeability, consistency under subsampling, and reversibility with respect to a tractable class of two-parameter partition models. These properties endow our model with a robustness to missing data, choice of labels, and changes in the sample over time. When combined with an appropriate model for response data, exchangeability and consistency give rise to the stronger model properties of label equivariance and non-interference, respectively. All of these properties are desirable for statistical applications, as they make model inferences easily interpretable and straightforward. We demonstrate these and other aspects with a detailed analysis of voting data in the Supreme Court over the period 1946–2012.
Health-related quality of life during and after stem cell transplantation

Health-related quality of life (HRQL) of 94 consecutive patients undergoing allogeneic stem cell transplantation (SCT) with myeloablative conditioning (MAC, n = 18) or reduced intensity conditioning (RIC, n = 76) was evaluated using the EORTC QLQ C-30 questionnaire at baseline and 12 times up to 3 years after SCT. Functional status and the global quality of life decreased from baseline to weeks 2 and 3, especially role and social functions. Symptoms increased significantly during the first three weeks, particularly appetite loss, nausea and vomiting, diarrhea, and fatigue. It took at least one year for HRQL to return to the baseline level. The only function that improved significantly three years after SCT was role function. MAC patients experienced worse HRQL at baseline than RIC patients, and subsequently more pain, sleep disturbance, and appetite loss in weeks 3 and 4. Patients with extensive chronic graft-versus-host disease (GvHD) experienced reduced HRQL. These results provide a good overview of patients’ symptoms and HRQL during and after SCT and indicate when they require increased support. The results also demonstrate the importance of close follow-ups during the first year after SCT in order to improve the preventive interventions, particularly regarding appetite loss and chronic GvHD.
CARACTERIZAÇÃO TÉRMICA DO SÚBER DE ESPÉCIES DO CERRADO

Este estudo apresenta a analise termica do suber de dez especies lenhosas do cerrado do municipio de Bauru, estado de Sao Paulo, Brasil. As amostras foram caracterizadas pelas tecnicas de analise termogravimetrica (TG), analise termica diferencial (DTA) e calorimetria exploratoria diferencial (DSC). Conclui-se que esse metodo mostra-se eficaz para avaliar a resistencia dessas especies ao fogo e que as caracteristicas susceptibilidade ou resistencia ao fogo variam entre as especies.
Grasping the interdisciplinarity of mechatronics

The two technical universities of Switzerland, the Swiss Federal Institute of Technology of Lausanne (EPTL) and Zurich (ETHZ), have a long tradition in mechatronics education. One successful part of this education at ETHZ is a lecture called Smart Product Design with a main emphasis on hands-on experience. Apart from providing the basics of mechatronics, the students work on a real mobile robot system during the course. Each student team receives a mobile robot kit, based on a Motorola 68332 microcontroller. Each year's course ends with a competition between the fully autonomous robots of the interdisciplinary student teams. In the recent years' competitions the students had to build robots to autonomously construct towers, to play golf or soccer, or to collect Lego students to bring them to school. The article briefly discusses the important aspects of mechatronics education and then focuses on the Smart Product Design course at ETHZ, discussing the lecture, the laboratory work, and the experience gained during the last eight years.
Efficacy of dried whey and its lactalbumin and lactose components at two dietary lysine levels on postweaning pig performance and nitrogen balance.

Two experiments were conducted to determine the efficacy of lactalbumin and lactose components of dried whey on gain and feed performance responses and N retention of weanling swine. In Exp. 1, a 2 x 5 factorial arrangement of treatments in a randomized complete block design in seven replicates was used to evaluate the efficacy of two dietary lysine levels (.90 and 1.30%) in 1) a corn-soybean meal (C-SBM) mixture, 2) C-SBM and 20% dried whey (C-SBM-DW), or the dried whey component replaced with 3 lactalbumin and cornstarch, 4) lactose and an amino acid mixture, or 5) the combination of lactalbumin and lactose. A total of 420 pigs weaned at 23 +/- 2 d of age, weighing an average of 6.87 kg BW, were used in a 3-wk experiment. Experiment 2 was a balance trial conducted as a 3 x 2 x 3 factorial arrangement in a split-plot design in three replicates. The negative (i.e., C-SBM) and positive (i.e., C-SBM-DS) control diets and the C-SBM-lactalbumin-cornstarch diets at the two lysine levels of Exp. 1 were the main plots, each evaluated for a 3-wk postweaning period. Growth rate (P less than .05), feed intake (P less than .01), N retention (P less than .01), and apparent N digestibility (P less than .05) were increased when pigs were fed the C-SBM-DW compared with the C-SBM diet. (ABSTRACT TRUNCATED AT 250 WORDS)
64-bit server cooling requirements

Cooling of 64-bit servers is constrained by increasing power and decreasing space. Power dissipation of high performance processors is predicted to increase linearly over the next decade. Thermal interface, heat spreading and heatsink-to-ambient convection each provide similar resistances in the thermal path from chip to ambient. One departure from previous practice will be the increasing sensitivity of power dissipation with junction temperature. As leakage current, previously a small contribution to total power dissipation, becomes significant, chip power dissipation will become a stronger function of temperature. Expenditure of energy on enhanced cooling, such as pumped water or vapor-cycle refrigeration, may result in reduced total system power. Recent advances in thermoelectrics could change many assumptions in refrigeration, enabling distributed and localized refrigeration at the processor level with minimum space requirements.
Signs of reversing trends in prevalence of asthma

Several recent reports have provided evidence that the burden of asthma may have levelled off, after increasing for decades. Implementation of the national and global asthma prevention and management guidelines that have led to earlier detection and improved treatment of asthmatics, is considered to be involved in this apparent change for the better. In addition, environmental influences associated with the modern life may have reached the maximum in inducing symptoms and disease in genetically susceptible individuals in some areas. Available data obtained from Canada and non‐English‐speaking countries in Europe show that the peak in asthma prevalence has been reached at the level of 8–12%. This review outlines the most recent literature on time trends in asthma prevalence and considers the possible causes of the current trends. Problems and pitfalls in appraising studies on time trends are also discussed.
Insulin resistance, role of metformin and other non‐insulin therapies in pediatric type 1 diabetes

Type 1 diabetes mellitus (T1DM) in youth is a challenging chronic medical condition. Its management should address not only the glycemic control but also insulin resistance and cardiovascular disease risk factors which are increasingly recognized to be present in youth with TID. Current knowledge on the mechanisms of insulin resistance in T1DM is reviewed. The use of adjunctive therapies that are beneficial to achieve adequate glycemic control while mitigating the effects of insulin resistance are discussed with a focus on metformin therapy and an overview of other new pharmacologic agents.
Factor Analysis of Permanent and Transitory Dynamics of the US Economy and the Stock Market

We analyze dynamics of the permanent and transitory components of the U.S. economic activity and the stock market obtained by multivariate dynamic factor modeling. We capture asymmetries over the phases of economic and stock market trends and cycles using independent Markov-switching processes. We show that both output and stock prices contain significant transitory components, while consumption and dividends are useful to identify their respective permanent components. The extracted economic trend perfectly predicts all post-war recessions. Our results shed light to the nature of the bilateral predictability of the economy and the stock market. The transitory stock market component signals recessions with an average lead of one quarter, whereas the market trend is correlated with the economic trend with varying lead/lag times.
Down-regulation of tissue microRNA-126 was associated with poor prognosis in patients with cutaneous melanoma.

BACKGROUND MiR-126 is frequently downregulated in a variety of malignancies and acts as a potential tumor suppressor. It also played a tumor suppressor role in human melanoma through the direct or indirect repression of several key oncogenic molecules. METHODS qRT-PCR assay was performed to examine the expression of miR-126. Associations between miR-126 expression and various clinicopathological characteristics were analyzed using the χ(2) test. Survival rate was determined with Kaplan-Meier and statistically analyzed with the log-rank method between groups. Survival data were evaluated through multivariate Cox regression analysis. RESULTS Significant differences for miR-126 expression were shown between dysplastic nevi and primary cutaneous melanoma (P<0.01), between primary melanoma and metastatic cutaneous melanomas (P<0.01), and between primary cutaneous melanomas and metastatic cutaneous melanomas (P<0.001). The patients with low miR-126 expression showed shorter 5-year overall survival than those with high miR-126 expression (P=0.039; log-rank test). Multivariate regression analysis showed that the status of miR-126 expression was an independent prognostic factor overall survival (HR=3.782, 95% CI: 2.479-16.334, P=0.005). CONCLUSION The status of miR-126 might be an independent prognostic factor for patients with cutaneous melanoma.
The Lexicon in FCIDB : A Friendly Chinese Interface for DBMS

FCIDB (Friendly Chinese Interface for DataBase management systems) can understand users' queries in the Chinese language. It works like a translator that translates Chinese queries into SQL commands. In the translation process, the lexicon of FCIDB plays a key role in both parsing and word segmentation. We designed some questionnaires to collect the frequently occurring words and add them to the public 'lexicon in FCIDB. FCIDB will produce a private lexicon for every new connected database. This paper will focus on the words included in the public lexicon and in the private lexicon. We also discuss the function, the structure, and the contents of the lexicon in FCIDB.
Interstitial fibrosis in the dilated non-ischaemic myocardium

Coronary artery occlusion and a variety of inflammatory disorders are followed by focal or segmental areas of fibrous scarring. The causes of interstitial fibrosis are less clear. Variable but sometimes dense interstitial fibrosis is seen in dilated cardiomyopathy.1 Some reports suggest that interstitial fibrosis is also increased in non-infarcted myocardium from hearts with ischaemic scars.2 Because of current interest in the pathophysiology of ventricular dilatation, we compared the interstitial collagen content of the left and right ventricles in dilated and undilated hearts of subjects without significant coronary artery occlusion. Our hypothesis was that we would find histological evidence of increased interstitial collagen content in dilated hearts. Forty four hearts were selected from approximately 500 necropsies of adults who died in the community or at Southampton University Hospitals over a six month period. For case selection mitral valve circumference was measured. Hearts with a mitral valve circumference > 110 mm were provisionally assigned to the test (dilated) group and those 50% of the external diameter of a major epicardial coronary artery; (4) valvar or congenital cardiac disease apart from mild thickening of the anterior mitral valve leaflet; and …
Computational Models of Face Perception

Faces are one of the most important means of communication for humans. For example, a short glance at a person’s face provides information about his or her identity and emotional state. What are the computations the brain uses to acquire this information so accurately and seemingly effortlessly? This article summarizes current research on computational modeling, a technique used to answer this question. Specifically, my research tests the hypothesis that this algorithm is tasked with solving the inverse problem of production. For example, to recognize identity, our brain needs to identify shape and shading features that are invariant to facial expression, pose, and illumination. Similarly, to recognize emotion, the brain needs to identify shape and shading features that are invariant to identity, pose, and illumination. If one defines the physics equations that render an image under different identities, expressions, poses, and illuminations, then gaining invariance to these factors can be readily resolved by computing the inverse of this rendering function. I describe our current understanding of the algorithms used by our brains to resolve this inverse problem. I also discuss how these results are driving research in computer vision to design computer systems that are as accurate, robust, and efficient as humans.
Current situation and future challenges of tobacco control policy in Thailand

In Thailand, the prevalence of smoking has steadily declined over the past 20 years, suggesting an effective tobacco control policy. However, the prevalence has recently stabilised and youth smoking now appears to be on the rise. Tobacco use is the third highest risk factor contributing to the burden of disease in the country. This is an issue of concern and led to the present review of tobacco control measures in Thailand. The present evidence-based review shows that Thailand's tobacco control measures are relatively strong and comply well with the WHO Framework Convention on Tobacco Control in terms of taxation, advertisement through popular media, and warning labels on cigarettes and other tobacco product packages. However, challenges remain in dealing with highly prevalent roll-your-own cigarettes, strict prohibition of tobacco sale to underage youths, household smoking, illicit trade of tobacco products, viable tobacco crop diversification for domestic tobacco growers and liability. If these challenges are met, the prevalence of tobacco consumption could possibly be further reduced.
Inactivation of p 53 and Pten promotes invasive bladder cancer

Department of Urology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA; Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New JerseyRobert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA; Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA; Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA; Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Design of Human Biomedical Signal Simulator Based on the SOPC

With the improvement of people's living standard, the demand of strengthening their health is increasing day by day. The emergence of multi-parameter monitor will always check whether the body's normal physiological parameters. However, with the increase of biomedical monitors, Functional testing of biomedical monitor are gradually strengthened. This paper designs a multi-parameter, high-performance, low power portable instrumentation, biomedical signal simulator. The system uses SOPC technology will integrate in one CPU, and design digital logic and distinctive Signal conditioning circuit in order to achieve technical indicators and monitoring functions, and achieve a variable resistance and increase the self-checking system. The paper designs the detailed waveform circuit, signal conditioning circuit and biomedical signal detection circuit, finally the system simulates various biomedical signal waveforms and show the data output by the man-machine interface. The system can be accomplished conveniently and quickly by using Altera Quartus II, SOPC Builder and Nios II IDE software. In a word, hardware design is more flexible than before, and system upgrades more and more convenient.
Among Multiple Phosphomannomutase Gene Orthologues, Only One Gene Encodes a Protein with Phosphoglucomutase and Phosphomannomutase Activities in Thermococcus kodakaraensis

ABSTRACT Four orthologous genes (TK1108, TK1404, TK1777, and TK2185) that can be annotated as phosphomannomutase (PMM) genes (COG1109) have been identified in the genome of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1. We previously found that TK1777 actually encodes a phosphopentomutase. In order to determine which of the remaining three orthologues encodes a phosphoglucomutase (PGM), we examined the PGM activity in T. kodakaraensis cells and identified the gene responsible for this activity. Heterologous gene expression and purification and characterization of the recombinant protein indicated that TK1108 encoded a protein with high levels of PGM activity (690 U mg−1), along with high levels of PMM activity (401 U mg−1). Similar analyses of the remaining two orthologues revealed that their protein products exhibited neither PGM nor PMM activity. PGM activity and transcription of TK1108 in T. kodakaraensis were found to be higher in cells grown on starch than in cells grown on pyruvate. Our results clearly indicate that, among the four PMM gene orthologues in T. kodakaraensis, only one gene, TK1108, actually encodes a protein with PGM and PMM activities.