Miracle-dz/UniFAR-FTUs huggingface dataset:
Physiological, Histological, and Molecular Analyses of Avocado Mesocarp Fatty Acids During Fruit Development

Fatty acids are important components of the avocado mesocarp, so a better understanding of how their change during fruit development will contribute to improving the quality of avocado fruits and their nutritional value. The changes in fatty acids, lipid droplets, and expression of some key genes and regulators participating in late glycolysis and fatty acid biosynthesis were analyzed at different stages of the development of avocado mesocarp. The total fatty acid contents of the avocado mesocarp increased during fruit development, with an increase by a factor of seven (from 1,628.04 to 11,116.30 mg/100 g dry weight) in the late stage of fruit maturation, this was confirmed by the changes observed in the lipid droplets. The composition of the main fatty acids varied at four developmental stages of fruit development. Palmitic, palmitoleic, oleic, and linoleic acid contents generally increased during fruit development, reaching maxima at Harvest, with percentages of total fatty acids of 50%, 9%, 31%, and 8%, respectively. Meanwhile, the amount of PaWRI1, PaACP4-2, and PapPK-β1 expressed consistently increased by up to 4-fold during fruit development. This comprehensive analysis has indicated that the changes in the expressions of PaWRI1, PaACP4-2, and PapPK-β1 were consistent with those in the total fatty acid contents, so they might have key roles in the accumulation of oil in the avocado mesocarp.
Giant Gastrointestinal Stromal Tumor of the Stomach

Gastrointestinal stromal tumors are the mostly seen mesenchymal tumors of the gastrointestinal system and mostly seen at the stomach. We report a case of giant gastrointestinal stromal tumor of the stomach in a 71-year-old woman. The physical examination and radiological findings revealed that a giant mass occupied most of the abdominal cavity. The patient underwent an en-block resection of this giant mass with partial resection of the distal stomach and transverse colon and, reconstruction with gastro-jejunostomy and end-to end colo-colic anatomoses. The histopathologic diagnosis was revealed as gastrointestinal stromal tumor of the stomach. We suggest that complete surgical resection is the only effective radical treatment approach for giant gastrointestinal stromal tumors of the stomach.
Fitoquímica de Ambrosia artemisiifolia L, Croton conduplicatus kunth, Lantana camara L, de la región norte de Colombia

En este trabajo, a partir de la investigacion como estrategia pedagogica se desarrollo la competencia de indagacion cientifi ca en los estudiantes del semillero de la Institucion Educativa Nuestra Senora de la Candelaria a partir del estudio de plantas medicinales de la zona urbana de Planeta Rica (Cordoba) fundamentado en la determinacion preliminar de metabolitos secundarios. Para ello, se recolecto material vegetal fresco de tres plantas medicinales conocidas comunmente como salvia (Croton conduplicatus Kunth), altamisa (Ambrosia artemisiifolia L) y venturosa (Lantana camara L). Se prensaron y enviaron al herbario nacional colombiano para su correcta identificacion; posteriormente, se recolectaron hojas frescas de cada planta y se sometieron a extraccion por maceracion por ocho dias empleando como solvente etanol al 96%. Cada extracto se concentro mediante evaporacion y fueron sometidos a marcha fi toquimica preliminar, sugiriendo la presencia de metabolitos secundarios como compuestos fenolicos, cumarinas, fl avonoides, terpenos, cardenolidos, taninos, saponinas y alcaloides.
Utilization of Self-Diagnosis Health Chatbots in Real-World Settings: Case Study

Background Artificial intelligence (AI)-driven chatbots are increasingly being used in health care, but most chatbots are designed for a specific population and evaluated in controlled settings. There is little research documenting how health consumers (eg, patients and caregivers) use chatbots for self-diagnosis purposes in real-world scenarios. Objective The aim of this research was to understand how health chatbots are used in a real-world context, what issues and barriers exist in their usage, and how the user experience of this novel technology can be improved. Methods We employed a data-driven approach to analyze the system log of a widely deployed self-diagnosis chatbot in China. Our data set consisted of 47,684 consultation sessions initiated by 16,519 users over 6 months. The log data included a variety of information, including users’ nonidentifiable demographic information, consultation details, diagnostic reports, and user feedback. We conducted both statistical analysis and content analysis on this heterogeneous data set. Results The chatbot users spanned all age groups, including middle-aged and older adults. Users consulted the chatbot on a wide range of medical conditions, including those that often entail considerable privacy and social stigma issues. Furthermore, we distilled 2 prominent issues in the use of the chatbot: (1) a considerable number of users dropped out in the middle of their consultation sessions, and (2) some users pretended to have health concerns and used the chatbot for nontherapeutic purposes. Finally, we identified a set of user concerns regarding the use of the chatbot, including insufficient actionable information and perceived inaccurate diagnostic suggestions. Conclusions Although health chatbots are considered to be convenient tools for enhancing patient-centered care, there are issues and barriers impeding the optimal use of this novel technology. Designers and developers should employ user-centered approaches to address the issues and user concerns to achieve the best uptake and utilization. We conclude the paper by discussing several design implications, including making the chatbots more informative, easy-to-use, and trustworthy, as well as improving the onboarding experience to enhance user engagement.
Tingkat Manajemen Laba pada Perusahaan Agribisnis dengan Aset Biologis di Wilayah Asia Setelah Konvergensi IFRS

The method of measuring biological assets is considered to provoke earnings management practices in agribusiness companies, especially in companies that have adopted IFRS in full. This study aims to examine whether agribusiness companies that have adopted IFRS in full will have a higher level of earnings management when compared to other industries. The sample of this study was taken from agribusiness companies in several Asian countries that are still in the IFRS convergence process. The research hypothesis was analyzed by independent t test to test the level of earnings management in the period before and after the convergence of IFRS. The results showed that agribusiness companies in the Asian region had higher average earnings management in the period after the IFRS convergence, when compared to before the IFRS convergence.
Cytotoxicity and apoptosis induction of sea cucumber Holothuria atra extracts

Context: Cancer is one of the major causes of death. Sea cucumbers are marine invertebrate that is widely used and utilized in traditional medicine. One of the most studied of sea cucumbers efficacy is its anticancer property. The anticancer property of sea cucumbers is much related to the content of an active compound called saponin. Objective: The objective of this research is to determine the cytotoxicity and apoptosis induction of sea cucumber Holothuria atra ethanol extract and to study its anticancer active compound. Materials and Methods: Sea cucumber of H. atra was taken from Halmahera waters, North Maluku Indonesia. The extraction was conducted by maceration method using ethanol 96% then continued with liquid-liquid partition and separation using C18 column. The investigation of active compound content was conducted by phytochemical and spectroscopic analysis using liquid chromatography-ion trap-time of a flight-mass spectrophotometer (LC-IT-ToF-MS). The cytotoxicity test was performed by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide method against human breast ductal carcinoma cell (T47D), human breast adenocarcinoma (MCF7), human colorectal adenocarcinoma cell (WiDr), and human cervix adenocarcinoma cell lines (HeLa). The apoptotic induction test was performed using flow cytometry using Fluorescein isothiocyanate (FITC) Annexin-V-Apoptosis and caspase-3 detection using FITC Active Caspase-3 kit. Results: Phytochemical test showed that ethanol extract of H. atra contained alkaloids, flavonoids, steroids-triterpenoids, phenols, and saponins. The extract showed cytotoxic activity against the 4 cell lines with Inhibition concentration 50 values ranging from 9.6 to 14.3 μg/ml. Flow cytometry analysis showed that the T47D cell population underwent apoptosis after treated with ethanol extract. The extract also activated caspase-3 on the T47D cells. The results of LC-IT-ToF-MS analysis showed that the active fraction from C18 column separation contained saponin and identified as Cucumechinol and Philinopgenin B. Conclusions: The results of this study indicated that H. atra active extract has good cytotoxicity and has potential to be developed as an anticancer agent. Abbreviations used: MNPs: Marine natural products; LC-IT-ToF-MS: Liquid chromatography-ion trap-time of flight-mass spectrophotometer; MTT: 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide; T47D: Human breast ductal carcinoma cell; MCF7: Human breast adenocarcinoma cell; WiDr: Human colorectal adenocarcinoma cell; HeLa: Human cervix adenocarcinoma cell; RPMI: Roswell park memorial institute medium; FBS: Fetal bovine serum; FITC: Fluorescein isothiocyanate; PBS: Phosphate buffer saline; BD: Becton Dickinson; IC50: Inhibition concentration 50; PS: Phosphatidylserine; PI: Propidium iodide.
Reefer logistics and cool chain transport

Reefer logistics is an important part of the cool chain in which reefer containers are involved as the packaging for transporting perishable goods. Reefer logistics is challenging, as it deals with cost and time constraints as well as the product quality and sustainability requirements. In many situations, there is a trade-off between these factors (e.g., between transportation time and the quality of fresh products). Furthermore, considering the high value of reefers, the efficient logistics of is as important as the efficient cargo flows. This causes technical complications and the conflict of interests between actors, especially, between cargo owners (or shippers) and the asset owners (or transport/terminal operators). Improving the efficiency of reefer logistics calls for a thorough understanding of the trade-offs and complexities. This paper aims to help develop such an understanding using a systematic literature review and a socio-technical system analysis. The results can be used to provide managerial insights for actors involved in a cool chain to design tailored solutions for reefer.
An Experimental Study of Richtmyer-Meshkov Instability

Richtmyer-Meshkov (RM) instability occurs when a planar interface separating two fluids of different density is impulsively accelerated In the direction of its normal. It is one of the most fundamental of fluid instabilities and is of importance in fields ranging from astrophysics to materials processing. Because RM instability experiments are normally carried out in shock tubes, where the generation of a sharp well controlled interface between gases is difficult, there is a scarcity of good experimental results. The experiments presented here utilize a novel technique which circumvents many of the experimental difficulties that have previously limited the study of RM instability. In this system, the instability is generated by bouncing a thin rectangular tank containing two liquids off of a fixed spring. Results obtained from these experiments yield particularly well visualized images of the nonlinear development of the instability. However, because the run time in these experiments is limited, new experiments capable of achieving longer run times are planned.
Functional study of Csrbohs in defence response against Xanthomonas citri ssp. citri.

NADPH oxidases, encoded by rbohs (respiratory burst oxidase homologues), transfer electrons from NADPH to molecular oxygen (O2) to generate superoxide anion (O2•-), which is the first step in the formation of hydrogen peroxide (H2O2) in the plant-pathogen interaction system. In the present work, six citrus rbohs (Csrbohs) genes were identified in citrus, and their possible involvement in resistance to Xanthomonas citri ssp. citri (Xcc) was examined. Inoculation with Xcc promoted the H2O2 production and induced expression of the Csrbohs, especially CsrbohD. Results showed that CsrbohD was markedly induced in the resistant genotype kumquat 'Luofu' [Fortunella margarita (Lour.) Swingle] compared with grapefruit 'Duncan' [Citrus paradisi (Linn.) Macf. ]. Virus-induced gene silencing (VIGS) of CsrbohD resulted in reduced resistance to Xcc in grapefruit, but not in kumquat. Compared with non-silenced plants, canker-like symptoms were observed earlier, and they were more extensive in the CsrbohD-silenced grapefruit. Silencing of CsrbohD also suppressed the Xcc induced reactive oxygen species (ROS) burst, and resulted in accumulation of more Xcc bacterial colonies. Taken together, these data indicate that CsrbohD promotes resistance to Xcc, especially in grapefruit.
HUBUNGAN WEISBOARD SIX BOX MODEL DAN EMPLOYEE ENGAGEMENT DENGAN KEPUASAN KERJA KARYAWAN

Penelitian ini bertujuan untuk melihat apakah ada hubungan antara aspek-aspek dalam Weisboard Six Box Model dan employee engagement dengan kepuasan kerja karyawan. Weisbord’s Six-Box Model diukur melalui enam aspek, yaitu tujuan, struktur, reward, tata hubungan, kepemimpinan, dan mekanisme. Employee engagement diukur dengan menggunakan tiga aspek yaitu vigor, dedication dan absorption. Sedangkan kepuasan dibedakan menjadi dua aspek yaitu kepuasan kerja intrisik dan ekstrinsik. Penelitian ini dilakukan terhadap 304 karyawan yang bekerja di Semarang, Solo, Boyolali, Tegal, Cilacap dan Yogyakarta. Pengumpulan data dilakukan dengan menggunakan survey online. Analisis regresi dan korelasi parsial digunakan dalam penelitian ini. Hasilnya menunjukkan ada hubungan yang singnifikan antara aspek-aspek dalam Weisboard Six Box Model dan Employee engagement dengan kepuasan kerja. Informasi terkait hasil analisis masing-masing variabel juga diberikan saran untuk melakukan perbaikan pada organisasi.
Spatially variant microstructured adhesive with one-way friction

Surface microstructures in nature enable diverse and intriguing properties, from the iridescence of butterfly wings to the hydrophobicity of lotus leaves to the controllable adhesion of gecko toes. Many artificial analogues exist; however, there is a key characteristic of the natural materials that is largely absent from the synthetic versions—spatial variation. Here we show that exploiting spatial variation in the design of one class of synthetic microstructure, gecko-inspired adhesives, enables one-way friction, an intriguing property of natural gecko adhesive. When loaded along a surface in the preferred direction, our adhesive material supports forces 100 times larger than when loaded in the reverse direction, representing an asymmetry significantly larger than demonstrated in spatially uniform adhesives. Our study suggests that spatial variation has the potential to advance artificial microstructures, helping to close the gap between synthetic and natural materials.
Developing Entrepreneurial Intention Through Improving Entrepreneurial Knowledge And Self Efficacy (Study On Participated Soft Skills Training Ready To Work Students of Semarang Private Universities)

- Entrepreneurship is a national treasure that must be protected, encouraged, and compensated in such a way because entrepreneurs are able to create jobs, opportunities, and prosperity for the country. This study aims to determine the effect of entrepreneurship knowledge and self-efficacy on entrepreneurial intention in Private Higher Education (PTS) students who attend Soft Skills Ready to Work Training in Semarang City. Respondents consist of 77 students. Data processed by multiple linear regression analysis. The results showed that there was a positive and significant effect of entrepreneurial knowledge and self-efficacy on entrepreneurial intention. Government and universities must give more attention to arise student’s entrepreneurial intention. Thus several ways must be prepared for students to have an entrepreneurial desire and intention so that the availability of new jobs can be created.
Identifying drug combinations of individual cancer patients by personalized drug controller method

It is a big challenge to identify patient-specific drug combinations based on cancer omics data. However, most conventional methods used for identifying personalized therapies require large sample sizes and focuse on the population as a whole and we still lack a feasible mathematical framework to circumvent this key problem in the clinical application of precision medicine. This work presents a personalized drug controller method (PDC) to identify drug combinations of individual cancer patients, by exploring the transition state information from a disease state to a normal state, thus providing novel insights into tumor heterogeneity in complex patient ecosystems. We validate the effectness of PDC in terms of the accurate prediction of drug combinations on two benchmark cancer datasets. We can also discover personalized key control genes (KCGs) even if the KCGs are hidden in transcription profiles by exploring their network and structural characteristics. Furthermore, we provide computationally derived side effect signatures for drug combinations based on patient-specific KCGs to enhance patient stratification and prognostication. The experimental results strongly support that PDC is effective for personalized drug therapy and treatment, and can fill the gap between network control theory and the personalized drug discovery problem.
Dinamika Industri dan Inovasi Produk Batik di Kampung Pesindon Kota Pekalongan.

Penelitian ini terfokus pada (1) Menganalisis Perkembangan industri batik di Indonesia khususnya di kota dengan julukan batik, kota Pekalongan. (2) Menganalisis adanya penetapan ‘Kota Kreatif Dunia’ dan peresmian kampung Pesindon sebagai kampung batik, yang merupakan objek penelitian. (3) Menganalisis pengaruh inovasi produk terhadap dinamika industri batik di kampung Pesindon. Populasi penelitian ini yaitu seluruh industri batik di paguyuban kampung Pesindon yang berjumlah 32 orang. Sampel yang digunakan dilakukan uji formula penentuan sampel slovin dengan rentan toleransi kekeliruan sebesar 5%, sehingga ukuran sampel ditentukan sebesar 30 orang. Uji coba yang dilakukan penelitian di kampung Kauman Kota Pekalongan. Metode pengumpulan data menggunakan observasi, dokumentasi dan angket. Uji coba instrumen menggunakan uji validitas dengan rumus korelasi product moment dan uji reliabilitas dengan rumus alpha cronbach. Metode analisis data menggunakan analisis statistik deskriptif dan inferensial. Statistik deskriptif menggunakan tabel distribusi frekuensi, dan grafik distribusi. Statistik inferensial diawali dengan uji asumsi klasik yang terdiri dari uji normalitas data, uji linearitas, uji heteroskedastisitas. Uji hipotesis menggunakan analisis regresi linier sederhana dan koefesien determinasi. Hasil penelitian menunjukkan bahwa terdapat pengaruh antara inovasi produk batik dengan dinamika industri di Kampung batik Pesindon Kota Pekalongan. Kontribusi tersebut menjelaskan bahwa 83,3% menyatakan bahwa inovasi produk batik yang terbentuk baik. Dan 86,7% menyatakan bahwa dinamika industri yang terbentuk baik.
Efficacy of Feeding Various Calcium Source and Concentration on Egg Quality, Some Blood Variables, and Performance of Aged Laying Hens

The primary aim of this study was to assay the influence of dietary Ca sources and levels on performance, egg quality indices, and selected blood variables of laying hens. A total of 192 Bovanz commercial layers were distributed to 6 dietary treatment groups with 4 replicates and 8 birds in each replicate. The experimental diets were iso-caloric and iso-nitrogenous, but they were different in the concentrations of available phosphorus and total calcium (0.29 and 3.8% or 0.31 and 4.0%, respectively) and in the origination of applied calcium (limestone A, limestone B, and oyster shell). Although the amounts of calcium and phosphorus were different among the diets, the ratio between them was the same in all diets. The results indicated that dietary treatments had not any significant effect on feed intake, feed conversion ratio, egg production, egg weight, egg mass, and body weight gain of hens. Egg quality indices were not influenced by dietary treatments in both egg sampling, except for eggshell weight and shell weight ratio, which decreased as a reduction of the dietary Ca level in the second period. The rate of broken, soft-shell and unmarketable eggs laid by the hens fed a diet containing lower Ca was increased. There was no significant effect of dietary Ca source and concentration on blood Ca and P, while serum ALP activity decreased significantly with increasing the amount of calcium in the diet. There was also, no interaction between Ca source and concentration for any of these parameters. Although all Ca sources applied in this experiment could supply the hens with sufficient Ca, the rate of unmarketable eggs decreased by using a higher concentration of Ca.
Antibacterial Activity of Laurus nobilis: A review of literature

The presence of phenolic compounds in spices and herbs, along with the essential oils, has been gaining attention due to their various functions like antioxidant capacity, antimicrobial properties, and flavoring properties. The Bay leaf belongs to Lauraceae family and is endemic in the Mediterranean region. Lauraceae , is an aromatic plant frequently used as a spice in Mediterranean cookery and as a traditional medicine for the treatment of several infectious disease. L. nobilis also belongs to Lauraceae. L. nobilis is aromatic tree, and is 2 m to 10 m high. L.nobilis contains about 1.3% essential oils and polar flavonoids mono, sesquiterpenes, alkoloids, glycosylated flavor-noids, megastigmane and phenolic components. It is known to have various pharmacological effects, including antimicrobial, cytotoxic and immune modulating. Its’ essential oil containg eucalyptol, α-terpinyl acetate, linalool, methyl eugenol, sabinene and carvacrol. The property of every essential oil varies according to the harvest country, altitude, period of sunshine, conditions of harvest. These essential oil contents of L. nobilis are strong antibacterial activity against Gram negative and Gram positive foodorne pathogens ( Salmonella , Staphylococcus aureus, Esherichia coli, Listeria monocytogenes like that), spoilage bacteria ( Pseudomonas aeroginosa ) as well as antifungal effects. The synergy between terpenes (linalool), lactones, oxides (1,8 cineole) and monoterpenes (camphene, alpa-pinene) gives to the essential oil of Laurel a good antibacterial activity. Its essential oils’ various or single chemical compositions at different concentrations have different inhibition mechanisms that can affect a variety of pathogens by changing membrane permeability, denaturing proteins and inhibiting enzymes. The oils are not affecting on existing beneficial intestinal bacteria.