Miracle-dz/UniFAR-FTUs huggingface dataset:
Gaze estimation based on head movements in virtual reality applications using deep learning

Gaze detection in Virtual Reality systems is mostly performed using eye-tracking devices. The coordinates of the sight, as well as other data regarding the eyes, are used as input values for the applications. While this trend is becoming more and more popular in the interaction design of immersive systems, most visors do not come with an embedded eye-tracker, especially those that are low cost and maybe based on mobile phones. We suggest implementing an innovative gaze estimation system into virtual environments as a source of information regarding users intentions. We propose a solution based on a combination of the features of the images and the movement of the head as an input of a Deep Convolutional Neural Network capable of inferring the 2D gaze coordinates in the imaging plane.
Germinal Center B Cells Are Essential for Collagen‐Induced Arthritis

Rheumatoid arthritis (RA) is considered to be a prototypical autoimmune disorder. Several mechanisms have been proposed for the known pathologic function of B cells in RA, including antigen presentation, cytokine secretion, and humoral immunity. The aim of this study was to address the function of B lymphocytes in experimental arthritis.
Transcription factor 7 like 2 promotes oligodendrocyte differentiation and remyelination

Transcription factor 7 like 2 (TCF7L2, also termed TCF4), is a Wnt effector induced transiently in the oligodendroglial lineage. The current well accepted hypothesis is that TCF7L2 inhibits oligodendrocyte differentiation and remyelination through canonical Wnt/β-catenin signaling. However, recent studies indicated that TCF7L2 activity is required during oligodendrocyte differentiation and remyelination. In order to clarify this, in situ hybridization, immunofluorescence and western blot analysis using in vivo TCF7L2 conditional knockout mice, were performed and it was found that TCF7L2 promotes oligodendrocyte differentiation during myelin formation and remyelination. Furthermore, it was established that TCF7L2 does not affect oligodendrocyte precursor cells during remyelination. These data are of important clinical significance to develop novel therapeutic targets to overcome multiple sclerosis and other demyelinating diseases.
TAP (NXF1) Belongs to a Multigene Family of Putative RNA Export Factors with a Conserved Modular Architecture

ABSTRACT Vertebrate TAP (also called NXF1) and its yeast orthologue, Mex67p, have been implicated in the export of mRNAs from the nucleus. The TAP protein includes a noncanonical RNP-type RNA binding domain, four leucine-rich repeats, an NTF2-like domain that allows heterodimerization with p15 (also called NXT1), and a ubiquitin-associated domain that mediates the interaction with nucleoporins. Here we show that TAP belongs to an evolutionarily conserved family of proteins that has more than one member in higher eukaryotes. Not only the overall domain organization but also residues important for p15 and nucleoporin interaction are conserved in most family members. We characterize two of four human TAP homologues and show that one of them, NXF2, binds RNA, localizes to the nuclear envelope, and exhibits RNA export activity. NXF3, which does not bind RNA or localize to the nuclear rim, has no RNA export activity. Database searches revealed that although only one p15(nxt) gene is present in the Drosophila melanogaster and Caenorhabditis elegans genomes, there is at least one additional p15 homologue (p15-2 [also called NXT2]) encoded by the human genome. Both human p15 homologues bind TAP, NXF2, and NXF3. Together, our results indicate that the TAP-p15 mRNA export pathway has diversified in higher eukaryotes compared to yeast, perhaps reflecting a greater substrate complexity.
Diversity Management in International Supply Chains: Strategies for Effectiveness

Managing diversity is the hallmark of an international business. International organizations deal with diversity in multiple task environments: culture, communication, operating, technology and supply chain. International organizations are integrated with global and host country local economies and systems. They need to continuously improve the supply chain effectiveness of their global operations to further their competitive position. The effective management of diversity will improve supply chain performance in procuring services, raw materials, components and sub-assemblies.
A two B-Z junction containing DNA resolves into an all right-handed double-helix.

Natural and artificial oligonucleotides are capable of assuming many different conformations and functions. Here we present results of an NMR restrained molecular modelling study on the conformational preferences of the modified decanucleotide d((m)C1G2(m)C3G4C5(L)G6(L)(m)C7G8(m)C9G10) . d((m)C11G12(m)C13G14C15(L)G (L)16(m)C17-G18(m)C19G20 ) which contains L deoxynucleotides in its centre. This chimeric DNA was expected to form a right-left-right-handed B-type double-helix (BB*B) at low salt concentration. Actually, it matured into a fully right-handed double helix with its central C(L)pG(L) core forming a right-handed Z-DNA helix embedded in a B-DNA matrix (BZ*B). The interplay between base-base and base-sugar stackings within the core and its immediately adjacent residues was found to be critical in ensuring the stabilisation of the right-handed helix. The structure could serve as a model for the design of antisense oligonucleotides resistant to nucleases and capable of hybridising to natural DNAs and RNAs.
Nachhaltiges Wirtschaften in Berliner Betrieben: Neue Formen des Wissenstransfers zwischen Hochschule und Unternehmen

Nachhaltiges Wirtschaften in kleinen und mittleren Unternehmen (KMU) ist ein aktuelles und sehr handlungsrelevantes Thema. Eine Hauptzielgruppe des Forschungsfelds nachhaltigen Wirtschaftens sind inzwischen klein- und mittelstandische Unternehmen. Nachhaltiges Wirtschaften ist notwendig fur die KMU, um in Bezug auf Material- und Ressourceneffizienz, Innovation und Ubernahme von gesellschaftlicher Verantwortung im Kerngeschaft zukunftsfahig zu sein. Offentlichkeitswirksam treten mit dem Thema Nachhaltigkeit bislang vermehrt die grosen und vornehmlich die am Kapitalmarkt aktiven Unternehmen in Erscheinung. Kunftig werden zunehmend die mittelstandischen Unternehmen zu ihren Nachhaltigkeitsaktivitaten gefragt werden, da sie meist in der Lieferkette der global agierenden Markenartikler eingebunden sind und dadurch steigendem Druck ausgeliefert sein werden, Nachhaltigkeitsthemen zu berucksichtigen. Nur zwischen der Notwendigkeit von Nachhaltigkeit und deren praktischer Umsetzung klafft noch eine grose Lucke. Wie kann nun uber den Wissenstransfer zwischen Hochschulen in Deutschland und Unternehmen das nachhaltige Wirtschaften in kleinen und mittleren Unternehmen gestarkt werden? In dem vorliegenden Working Paper wird dieser Frage am Beispiel des an der Hochschule fur Wirtschaft und Recht (HWR) in Berlin von 2009 - 2011 durchgefuhrten Transferprojekts Nachhaltiges Wirtschaften in Berliner Betrieben (NBB) nachgegangen. Das Ziel des Projekts war es, insbesondere Berliner Betriebe dahingehend zu unterstutzen, Nachhaltigkeitsprojekte so durchzufuhren, dass die daraus resultierenden Erkenntnisse dauerhaft in die Unternehmensprozesse eingebunden werden.
Recent Proliferation and Translocation of Pollen Group 1 Allergen Genes in the Maize Genome1[W][OA]

The dominant allergenic components of grass pollen are known by immunologists as group 1 allergens. These constitute a set of closely related proteins from the β-expansin family and have been shown to have cell wall-loosening activity. Group 1 allergens may facilitate the penetration of pollen tubes through the grass stigma and style. In maize (Zea mays), group 1 allergens are divided into two classes, A and B. We have identified 15 genes encoding group 1 allergens in maize, 11 genes in class A and four genes in class B, as well as seven pseudogenes. The genes in class A can be divided by sequence relatedness into two complexes, whereas the genes in class B constitute a single complex. Most of the genes identified are represented in pollen-specific expressed sequence tag libraries and are under purifying selection, despite the presence of multiple copies that are nearly identical. Group 1 allergen genes are clustered in at least six different genomic locations. The single class B location and one of the class A locations show synteny with the rice (Oryza sativa) regions where orthologous genes are found. Both classes are expressed at high levels in mature pollen but at low levels in immature flowers. The set of genes encoding maize group 1 allergens is more complex than originally anticipated. If this situation is common in grasses, it may account for the large number of protein variants, or group 1 isoallergens, identified previously in turf grass pollen by immunologists.
Mental health of sexual minorities. A systematic review

Abstract Many studies, reviews, and meta-analyses have reported elevated mental health problems for sexual minority (SM) individuals. This systematic review provides an update by including numerous recent studies, and explores whether SM individuals are at increased risk across selected mental health problems as per dimensions of sexual orientation (SO), genders, life-stages, geographic regions, and in higher quality studies. A systematic search in PubMed produced 199 studies appropriate for review. A clear majority of studies reported elevated risks for depression, anxiety, suicide attempts or suicides, and substance-related problems for SM men and women, as adolescents or adults from many geographic regions, and with varied SO dimensions (behaviour, attraction, identity), especially in more recent and higher quality studies. One notable exception is alcohol-related problems, where many studies reported zero or reversed effects, especially for SM men. All SM subgroups were at increased risk, but bisexual individuals were at highest risk in the majority of studies. Other subgroup and gender differences are more complex and are discussed. The review supports the long-standing mental health risk proposition for SM individuals, overall and as subgroups.
Repository January 2018 SOL : Segmentation with Overlapping Labels

Image segmentation is a fundamental problem in Computer Vision which involves segmenting an image into two or more segments. These segments usually correspond to objects of interest in the image, i.e. liver, kidney’s etc. The classic approach to this problem segments the image into mutually exclusive segments. However, this approach is not well-suited when segmenting overlapping objects, e.g. cells, or when segmenting a single object into multiple parts that are not necessarily mutually exclusive. Moreover, we show that optimization methods for multi-part object segmentation with different priors/constraints may better avoid local minima in case of a relaxation allowing parts to overlap. We propose a novel segmentation model, i.e. Segmentation with Overlapping Labels (SOL), which allows for the objects’ multiple parts to overlap. This aids in overcoming the aforementioned issue of local minima with standard optimization approaches. We prove that SOL is an NP-hard problem, as well as introduce a novel move-making optimization framework to find an approximate solution to SOL. Our qualitative and quantitative results show that our proposed method outperforms state-of-the-art algorithms for multi-part segmentation.
Cancer Incidence in a Population Accidentally Exposed to 2,3,7,8‐Tetrachlorodibenzo-para‐dioxin

In 1976, an accident in a plant near Seveso, Italy, exposed the local population to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Persons residing in three zones of decreasing TCDD contamination (A, B, and R) and a reference population were followed up for cancer occurrence in 1977–1986. The most exposed subgroup (A) was small, and only 14 cancer cases were observed. In zone B, hepatobiliary cancer was elevated, especially for those living in the area for >5 years [relative risk (RR) = 2.8; 95% confidence interval (CI) = 1.2–6.31. Men exhibited an increase in hematologic neoplasms, most notably lymphoreticulosarcoma (RR = 5.7; 95% CI = 1.7–19.0). Women experienced an increased incidence of multiple myeloma (RR = 5.3; 95% CI = 1.2–22.6) and myeloid leukemia (RR = 3.7; 95% CI = 0.9–15.7). In zone R, the incidence of soft tissue tumors and non-Hodgkin's lymphomas was elevated, particularly among persons living in the area for >5 years (RR = 3.5; 95% CI = 1.2–10.4 for sarcomas, and RR = 2.0; 95% CI = 1.2–3.6 for non-Hodgkin's lymphomas). Breast cancer among females was below expectations in the most contaminated zones, and a clear deficit for endometrial cancer was observed in zones B and R. (Epidemiology 1993;4:398–406)
Features to validate cerebral toxoplasmosis.

INTRODUCTION Neurotoxoplasmosis (NT) sometimes manifests unusual characteristics. METHODS We analyzed 85 patients with NT and AIDS according to clinical, cerebrospinal fluid, cranial magnetic resonance, and polymerase chain reaction (PCR) characteristics. RESULTS In 8.5%, focal neurological deficits were absent and 16.4% had single cerebral lesions. Increased sensitivity of PCR for Toxoplasma gondii DNA in the central nervous system was associated with pleocytosis and presence of >4 encephalic lesions. CONCLUSIONS Patients with NT may present without focal neurological deficit and NT may occur with presence of a single cerebral lesion. Greater numbers of lesions and greater cellularity in cerebrospinal fluid improve the sensitivity of PCR to T gondii.
Revising the scope of practice for oral health professionals: enter genomics.

http://jada.ada. org/content/145/3/228 can be found in the online version of this article at: including high-resolution figures, Updated information and services http://jada.ada. org/content/145/3/228/#BIBL , 9 of which can be accessed free: 14 articles This article cites http://www.ada. org/990.aspx at: permission to reproduce this article in whole or in part can be found of this article or about reprints Information about obtaining
Towards a Richer Set of Services in Software-Defined Networks

Software-Defined Networking (SDN) has drawn increasing attention from both industry and academia, owing to its premise to simplify the management and control over large networks. While the SDN technology was initially deployed within datacenters, there are currently early deployments of SDN in Wide-Area Networks; SDN is further envisioned to be deployed in the near future within fixed and mobile networks. In this paper, we show that the envisioned deployment of SDN within operator networks opens the doors to novel network security services that the operators can efficiently offer. More specifically, we propose in this work two exemplary operator services; our first solution enables the construction of secure location proofs for registered network users. Our second solution offers users the possibility to request the setup of network paths that are tailored to their specific security constraints, e.g., that only cross domains regulated by appropriate legislations which match their security policies. We show that this can be securely and efficiently attained by leveraging basic functionality from the OpenFlow protocol. In this respect, we evaluate the feasibility of our proposals by means of implementation within a realistic testbed composed of hardware OpenFlow-enabled switches; our findings suggest that our proposals can be deployed with minimal overhead within existing SDN-enabled networks.
Vibrational Circuit Breaker Using Ferromagnets and Repulsive Magnets

This paper proposes a vibrational circuit breaker which cuts an electric and/or electronic circuit by vibration of acceleration more than a certain value. This structure consists of a fixed magnet, a moving magnet, and a fixed part of two ferromagnets/magnet. It works from on-state to off-state when the two ferromagnets separate. This vibrational circuit breaker has advantages: auto-detection, no battery, and simple structure.
Reoxygenation and Split-Dose Response to Radiation in a Tumour Model with Krogh-Type Vascular Geometry

After a single dose of radiation, transient changes caused by cell death are likely to occur in the oxygenation of surviving cells. Since cell radiosensitivity increases with oxygen concentration, reoxygenation is expected to increase the sensitivity of the cell population to a successive irradiation. In previous papers we proposed a model of the response to treatment of tumour cords (cylindrical arrangements of tumour cells growing around a blood vessel of the tumour). The model included the motion of cells and oxygen diffusion and consumption. By assuming parallel and regularly spaced tumour vessels, as in the Krogh model of microcirculation, we extend our previous model to account for the action of irradiation and the damage repair process, and we study the time course of the oxygenation and the cellular response. By means of simulations of the response to a dose split in two equal fractions, we investigate the dependence of tumour response on the time interval between the fractions and on the main parameters of the system. The influence of reoxygenation on a therapeutic index that compares the effect of a split dose on the tumour and on the normal tissue is also investigated.
The End of Big: How the Internet Makes David the New Goliath

In "The End of Big", Internet pioneer and Harvard Kennedy School lecturer Nicco Mele draws on nearly twenty years of experience to explore the consequences of revolutionary technology. Our ability to connect instantly, constantly, and globally is altering the exercise of power with dramatic speed. Governments, corporations, centres of knowledge, and expertise are eroding before the power of the individual. It can be good in some cases, but as Mele reveals, the promise of the Internet comes with a troubling downside. Unless we exercise deliberate moral choice over the design and use of technologies, Mele says, we doom ourselves to a future that tramples human values, renders social structures chaotic, and destroys rather than enhances freedom. Both hopeful and alarming, thought-provoking and passionately-argued, "The End of Big" is an important book about our present - and our future.
[Infants aged 3-24 months with fever without source in the emergency room: characteristics, management and outcome].

OBJECTIVE To determine the characteristics of infants aged 3-24 months admitted to a Hospital Pediatric Emergency Room with fever without source, the management of these infants and their subsequent outcome. PATIENTS AND METHOD We performed a retrospective survey of 733 children aged 3-24 months with fever without source admitted to our Emergency Room between September 1, 2003 and December 31, 2003. Subsequently, the parents of all infants diagnosed with fever without source who were managed as outpatients were telephoned to ascertain their outcome and changes in the final diagnosis. RESULTS Onset of fever occurred less than 6 hours before arrival at the hospital in 237 episodes (32.2%). The family reported a temperature of > or = 39 degrees C in 436 episodes. Diagnoses in the Emergency Room were the following: fever without source in 677 (92.3%), urinary tract infection in 53 (7.2%) and bacterial meningitis in three (0.4 %). Fifty-five infants with an altered dipstick were excluded and complete blood count (CBC) and blood culture were performed in 66 infants (9.7%). There was a significant negative association between the probability of a request for CBC and blood culture and higher age [6-11 months vs. 3-6 months OR 0.24 (95 % CI: 0.11-0.49); > or = 12 months vs. 3-6 months, OR 0.15 (0.07-0.3)] and a significant positive association with onset more than 12 hours previously [vs. less than 6 hours OR 2.3 (1.2-4.43)] and highest temperature registered at home > 40 degrees C [vs. less than 39 degrees C OR 4.22 (1.5-11.84)]. Follow-up was completed (by telephone or readmission to the Emergency Room) in 574 infants diagnosed with fever without source and managed as outpatients. The final diagnosis differed from that made in the Emergency Room in 158 infants (27.5%), and 70 received antibiotics (12.1%). CONCLUSIONS A considerable percentage of infants aged 3-24 months with fever without source visits the Emergency Room with very short-term processes. Patient observation is very useful in the management of these infants, since the final diagnosis differed from that made in the emergency room in nearly 30% and 12% were treated with antibiotics.
Atypical clinical and pathological findings in a patient with isolated cortical vein thrombosis★

Isolated cortical vein thrombosis often produces a focal lesion. Because of the rapid development of collateral circulation, increased intracranial pressure has never been reported in a patient with isolated cortical vein thrombosis. The diagnosis of isolated cortical vein thrombosis is based mainly on MRI, catheter digital subtraction angiography, and histological findings, but may be challenging. We report a patient who presented with intermittent seizures and left-sided limb weakness. Her symptoms gradually progressed, and she eventually developed signs of increased intracranial pressure. Imaging studies showed a space-occupying lesion in the right frontal lobe of the brain. As we could not diagnose isolated cortical vein thrombosis based on the preoperative findings, surgical excision of the lesion was performed under general anesthesia. Histological examination showed destruction of the brain parenchyma with infiltration of macrophages, proliferation of reactive astrocytes and small vessels, and foci of hemorrhage. Further examination found that a number of small vessels in both the subarachnoid space and brain parenchyma were filled with thrombus, some of which was organized. Elastic fiber staining showed that the obstructed vessels were veins. We diagnosed isolated cortical vein thrombosis with atypical clinical features.
Community level cancer control in a Texas barrio: Part I--Theoretical basis, implementation, and process evaluation.

A theory-based program that used peer modeling and a network of peer communicators to promote breast and cervical cancer screening was designed and implemented in a barrio of San Antonio with a population of approximately 25,000 adult women. The implementation process was evaluated and documented through field notes, archival documents, content analyses, interviews, surveys, etc. Over a 21-month period, a total of 156 new stories and a network for distribution of more than 80,000 print pieces carried messages about positive role models who were receiving Pap smears and mammograms. A group of 85 volunteers were recruited to promote screening; these volunteers reached 2000-3000 women each month with personal contacts in which cancer screening was encouraged. A small group of volunteers offered particularly intensive assistance to their peers, e.g., helping them to make and keep appointments for screening examinations. The theoretical communication model for the program, which maximizes audience and community participation as sources and channels for messages, was well suited for the cross-cultural application presented here.
Rethinking the Consanguineal Household and Matrifocality

L'A. reprend l'analyse de la structure de la famille des Carib noirs (Garifuna) de Livingston, Guatemala, qu'il avait realisee en 1956, a partir de nouvelles donnees reunies en 1975. Cette famille se caracterise en general comme groupe domestique consanguin et matrilocal.
Toll‐like receptor 9 promoter polymorphism as a predictive factor of narrow‐band UVB phototherapy response in patients with psoriasis

Prediction of response to ultraviolet B (UVB) phototherapy in psoriatic patients mainly relies on clinical criteria, although some genetic predictors have been identified. Toll‐like receptors (TLRs) have been involved in psoriasis pathogenesis through activation of the innate immune system. Their polymorphisms may condition not only the clinical profile of psoriasis but also the response to therapy.