Miracle-dz/UniFAR-FTUs huggingface dataset:
Ethnic Differences in the Clusters of Menopausal Symptoms

Our purpose for this study was to identify clusters of midlife women by menopausal symptoms in a multiethnic sample, and to determine ethnic differences in the clusters. This was a secondary analysis of data from 501 women in a larger Internet study on menopausal symptom experiences. The data were analyzed using factor analysis, hierarchical cluster analysis, and multinominal logistic analysis. A three cluster solution was adopted (F = 575.71, p <.01). The clusters differed significantly in the country of birth and ethnicity (p <.05). Only in the low symptomatic cluster were there significant ethnic differences in menopausal symptoms.
Modulated bone matrix-related gene expression is associated with differences in interfacial strength of different implant surface roughness.

PURPOSE The objective of this study was to examine the effect of implant surface topography on biomechanical strength and expression patterns of bone extracellular matrix (ECM)-related genes during implant healing. MATERIALS AND METHODS Cylinder implants with turned or dual acid-etched (DE) surface were placed into the femurs of female Sprague-Dawley rats. At 2 and 4 weeks after the implantation, the implant push-in test was performed to measure the load-bearing strength of the bone-tissue interface. T-shaped hollow implants were separately placed and the total RNA was extracted from the ingrown tissue within the hollow chamber. The RNA was subjected to reverse transcriptase polymerase chain reaction to analyze the expression pattern of selected bone extracellular matrix-related genes. RESULTS The push-in value of the DE implant is approximately 300% greater than that of the turned implant at weeks 2 and 4 (p=.0090). The expression of collagen II, osteocalcin and biglycan was higher in the week 2 DE implant group than the turned implant group. At week 4 the expression of collagen II and IX was 7- and 26-fold, respectively, greater in the DE implant group than in the turned implant group. CONCLUSIONS The surface topography of implants may induce the phenotypic alteration of wound healing cells. The increased interfacial strength of the DE implant may be associated with the modulated expression of the selected set of bone extracellular matrix genes.
Up‐regulation of adenosine A1 receptors in frontal cortex from Pick's disease cases

The adenosine A1 receptor (A1R)–adenylyl cyclase (AC) pathway was studied in post‐mortem human frontal and occipital cortex from Pick's disease (PiD) cases and age‐matched nondemented controls. In frontal cortex, the main brain area affected in PiD, A1Rs, determined by radioligand binding, Western blotting and real‐time PCR assays, were significantly increased in PiD samples, suggesting up‐regulation of this receptor. AC activity was determined in basal and stimulated conditions via stimulatory guanine nucleotide binding proteins (Gs) using GTP, or directly with forskolin. Basal AC activity was reduced in brains from PiD cases. This agrees with the decrease in AC type I (AC I) level detected by Western blotting. However, inhibition of forskolin‐stimulated AC activity by a selective A1R agonist was significantly increased in brains from PiD. In occipital cortex, adenosine A1R numbers were similar in control and PiD cases, and no significant differences were found in A1R‐mediated AC inhibition. These results show that the adenosine A1R–AC transduction pathway is specifically up‐regulated and sensitized in frontal cortex brain in PiD.
Effect of an intensive care unit rotating empiric antibiotic schedule on the development of hospital-acquired infections on the non–intensive care unit ward

ObjectiveWe have previously shown that a rotating empirical antibiotic schedule could reduce infectious mortality in an intensive care unit (ICU). We hypothesized that this intervention would decrease infectious complications in the non-ICU ward to which these patients were transferred. DesignProspective cohort study. SettingAn ICU and the ward to which the ICU patients were transferred at a university medical center. PatientsAll patients treated on the general, transplant, or trauma surgery services who developed hospital-acquired infection while on the non-ICU wards. InterventionsA 2-yr study consisting of 1-yr non–protocol-driven antibiotic use and 1-yr quarterly rotating empirical antibiotic assignment for patients treated in the ICU from which a portion of the patients were transferred. Measurements and Main ResultsThere were 2,088 admissions to the non-ICU wards during the nonrotation year and 2,183 during the ICU rotation year. Of these patients, 407 hospital-acquired infections were treated during the nonrotation year and 213 were treated during the ICU rotation (19.7 vs. 9.8 infections/100 admissions, p < .0001). During the ICU rotation year a decrease in the rate of resistant Gram-positive and resistant Gram-negative infections on the non-ICU wards occurred (2.5 vs. 1.6 infections/100 admissions, p = .04; 1.0 vs. 0.4 infections/100 admissions, p = .03). Subgroup analysis revealed that the decrease in resistant infections on the wards was due to a reduction in resistant Gram-positive and resistant Gram-negative infections among non-ICU ward patients admitted initially from areas other than the ICU implementing the antibiotic rotation (e.g., home, other ward, or a different ICU) (1.8 vs. 0.5 infections/100 admissions, p = .0001; 0.7 vs. 0.2 infections/100 admissions, p = .02), not due to differences for those transferred to the ward from the rotation ICU (10.4 vs. 9.7 infections/100 admissions, p = 1.0; 4.3 vs. 1.9 infections/100 admissions, p = .3). No differences in infection-related mortality were detected. ConclusionsAn effective rotating empirical antibiotic schedule in an ICU is associated with a reduction in infectious morbidity (hospital-acquired and resistant hospital-acquired infection rates) on the non-ICU wards to which patients are transferred.
Glycemic and cardiovascular parameters improved in type 2 diabetes with the high nutrient density (HND) diet

Objective: The purpose of this study was to provide an initial assessment of the effectiveness of the high nutrient density (HND) diet on glycemic control and cardiovascular risk factors in participants with type 2 diabetes. Design: This was a retrospective case series study. Participants were 13 adult type 2 diabetic U.S. women and men between the ages of 30 - 80 years old. Glycosylated hemoglobin (HbA1C), lipid profile, blood pressure, BMI, and medication requirements before and after commencement of the HND diet were compared. Results: After a median length on the HND diet of 7 months, the mean HbA1C dropped from 8.2% to 5.8% (p = 0.002), with sixty-two percent of participants reaching normoglycemic levels (HbA1C p = 0.0004 for systolic blood pressure, p = 0.01 for diastolic blood pressure). Triglycerides significantly decreased from a mean of 171 mg/dl to a mean of 103 mg/dl (p = 0.02). The HDL increased significantly from 48.3 mg/dl to 54.6 mg/dl (p = 0.03). The mean number of medications dropped from 4 to 1 (p = 0.0006). Conclusions: The HND diet was very effective in controlling glycemic levels and cardiovascular risk factors in 13 participants with type 2 diabetes. Therefore, there is a well-justified need for further study with the HND diet.
Direction of arrival estimation using robust complex Lasso

The Lasso (Least Absolute Shrinkage and Selection Operator) has been a popular technique for simultaneous linear regression estimation and variable selection. In this paper, we propose a new novel approach for robust Lasso that follows the spirit of M-estimation. We define M-Lasso estimates of regression and scale as solutions to generalized zero sub-gradient equations. Another unique feature of this paper is that we consider complex-valued measurements and regression parameters, which requires careful mathematical characterization of the problem. An explicit and efficient algorithm for computing the M-Lasso solution is proposed that has comparable computational complexity as state-of-the-art algorithm for computing the Lasso solution. Usefulness of the M-Lasso method is illustrated for direction-of-arrival (DoA) estimation with sensor arrays in a single snapshot case.
c‐Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II.

We show that c‐Myc, in addition to activating transcription through E‐box Myc binding sites (Ems), also represses transcription by a mechanism dependent on initiator (Inr) elements of the basal promoters of susceptible genes. Repression was first observed as a component of c‐Myc biphasic regulation of the adenovirus‐2 major late promoter (MLP), which contains both Inr and Ems sequences. Two differentiation‐specific genes containing Inr, the C/EBP alpha and albumin genes, are repressed through their basal promoters by c‐Myc, but are activated by the related B‐HLH‐LZ factor, USF. Repression requires both the B‐HLH‐LZ and Myc box II (MBII) domains. Significantly, a MBII deletion mutant which is deficient in repression, but transactivates normally, fails to cooperate with an activated ras gene to transform primary fibroblasts. Thus Myc‐dependent transactivation is insufficient for Ras cooperation and the novel transcription repression function is implicated in Ras cooperation as well as the suppression of Inr‐dependent genes.
Kalman filter approach for identification of linear fast Time-Varying processes

This paper deals with the use of Kalman filter approach for identification of linear fast time-varying processes. Most of the physical processes exhibit some degree of time-varying behavior. Physical processes exhibit time-varying behavior for a number of reasons. Some of the processes are inherently time-varying and can not effectively be modeled using time invariant models. Recursive identification methods are useful for the parameters estimation while the system is in operation. The model should then be based on observations up to the current time. In online identification the current estimates of the system are constantly being calculated. In this paper we employed first order Time-Varying (TV) Auto-Regressive with eXogenous (ARX) model and its fast varying parameters are estimated using recursive Kalman filter method. The input is Pseudo-Random Binary Sequence (PRBS) which is frequency rich signal. Parameters are estimated for different noise conditions. The performance of the method is evaluated by calculating error performance measures. The results depict the suitability of the method.
Multiple media cues for MPEG-7

This work presents a methodology to extract and represent the semantic content of audio-visual documents. A collection of diverse tools is used to extract low level, signal based descriptions. Joint audio and visual analysis is utilized to automatically extract higher level semantic features. High-level, hand-annotated, descriptors are also used. The hand annotated descriptors are used for retrieval purpose as well as to enhance the results of the automatic procedure, i.e. to allow the system to learn how high level semantic information are linked to low level automatically extracted features through user's input. We draw upon MPEG-7's collection of Descriptors to provide some targets for our audio and visual analysis methods. Selected MPEG-7 Description Schemes, such as the textual description, the description of persons, and the description of the structural aspects of the content of the AV document [1], provide some of the larger containment structures for our features.
N-(4-substituted-thiazolyl)oxamic acid derivatives, a new series of potent, orally active antiallergy agents.

A series of N-(4-substituted-thiazolyl)oxamic acid derivatives were synthesized and tested for antiallergy activity in the rat PCA model. These compounds were conveniently prepared by treatment of the appropriate acetophenone with thiourea and iodine or by reaction of the chloroacetylbenzene with thiourea to give the corresponding aminothiazoles; subsequent condensation with ethyloxalyl chloride gave the thiazolyloxamates. Many of the analogues showed a 50% inhibition at less than 2 mg/kg po or less than 0.4 mg/kg iv and were significantly more potent than disodium cromoglycate, which in the rat PCA model is orally inactive and gives a 50% inhibition at 1.2 mg/kg iv. Hydrolysis of the oxamates generally resulted in enhanced activities, while substitution of the phenyl ring with a variety of substituents (e.g., 4-F, 4-OEt, and 4-NHCOCH3) did not significantly enhance the activity of the unsubstituted phenyl derivative. One of the ethanolamine salts, N-[4-(1,4-benzodioxan-6-yl)-2-thiazolyl]oxamic acid ethanolamine salt (61, PRH-836-EA), has been selected for further pharmacological evaluation.
Demonstration of synergy with fluconazole and either ibuprofen, sodium salicylate, or propylparaben against Candida albicans in vitro

The combination of fluconazole with either ibuprofen, sodium salicylate, or propylparaben resulted in synergistic activity (fractional inhibitory index, < 0.5) against Candida albicans NCYC 620 in a microdilution checkerboard assay. Synergism between miconazole and ibuprofen was also demonstrated. In three or four clinical isolates of C. albicans from AIDS patients, the combination of fluconazole and ibuprofen was synergistic. Preparation of the inoculum and the growth conditions used were those recommended by the National Committee for Clinical Laboratory Standards for susceptibility testing. A visual estimation of total inhibition of growth and determination of an 80% reduction in the optical density at 492 nm compared with those for the control were taken as endpoints for the calculation of synergy, and a good correlation between both estimates was demonstrated.
Obstetric Outcomes at Advanced Maternal Age

Objective: To compare obstetric outcomes among women at advanced maternal age in relation to another group of 20 to 29 years. Methods: this is an observational descriptive study. Women of advanced maternal age were 40 and older at the first pregnant control (N = 154). The control group were pregnant women between 20 and 29 years (N = 3900). Odds ratio (CI 95%), mean and standard deviation, median and Fisher exact test were used to compare. Results: The rate of chronic hypertension, preeclampsia, diabetes, and bleeding were higher in the study group when compared with the control group. The rate of caesarean sections (due to a great number of elective ones), preterm delivery <37 weeks and lower birth weight (< 2500g) were also higher in the study group. Conclusion: women at advanced maternal age have an increased risk of adverse outcomes during pregnancy and delivery compared to pregnant women between 20 and 29 years. This electronic document is a “live” template. The various components of your paper [title, text, heads, etc.] are already defined on the style sheet, as illustrated by the portions given in this document.
Efficient computation of manipulator inertia matrices and the direct dynamics problem

A modeling scheme that uses the concepts of generalized and augmented links is proposed for computing joint-space inertia matrices of open-chain rigid body systems. Expressions for evaluating these matrices are derived, utilizing orthogonal Cartesian tensors and the Newton-Euler equations of motion. The resulting recursive algorithm is applicable to all rigid-link manipulators having open-chain kinematic structures with revolute and/or prismatic joints. An efficient implementation of the algorithm shows that the joint-space inertia-matrix of a six degree-of-freedom manipulator with revolute joints can be computed in approximately 420 multiplications and 339 additions. For manipulators with 0 degrees to 90 degrees twist angles, the number of computations is reduced to 271 multiplications and 250 additions. >
Zinc in depressive disorder

Plasma zinc levels were measured in 14 patients with primary affective disorder on admission to hospital; they were compared with plasma zinc levels in group of 14 age‐ and sex‐matched controls. A significant difference in zinc levels was found between the 2 groups. Plasma zinc levels of 9 of the depressed patients on admission to hospital and at the point of discharge were compared; a significant increase in zinc levels was detected.
What's new in orthopaedic trauma.

s of these 307 studies were reviewed in duplicate for final inclusion by one of us (P.A.C.). After abstract selection, 136 articles were divided among all authors according to their specialty focus for critical review. Thirty-eight manuscripts were discarded, leaving ninety-eight studies for final inclusion in this update. Consensus on the final studies was achieved. In this review, we summarize the salient findings of twenty-four level-I studies, twenty-seven level-II studies, ten level-III studies, and thirty-six level-IV studies across subspecialties of orthopaedic trauma. Of these, fifty-nine represented studies of therapy, thirty-one involved prognosis, six evaluated diagnostic tests, and one involved economic and decision analyses (see Appendix). One of the final studies, which developed an evidence-based algorithm, was nonclassifiable. Based on positive feedback from last year’s update, we have brought back the basic science section author (T.M. III) to help us to interpret key bench research projects that we believe to have a high level of clinical relevance. Twenty recognized experts were asked to identify the one or two most important trauma-related research articles in their field.
VH gene expression in hairy cell leukaemia

Hairy cells are characterized by their typical morphology and expression of specific surface antigens. Although their B‐cell origin is now confirmed, their exact position in B‐cell development remains unclear. To better define the origin of hairy cells, we analysed the immunophenotype and the Ig VH nucleotide sequence of seven cases of hairy cell leukaemia (HCL). Six of them were typical HCL and the remaining case corresponded to a variant HCL. Analysis of sequenced VH genes revealed that the VH1 family was used in one case, VH2 in one, VH3 in two, VH4 in two and VH5 in one. No preferential usage of VH genes was observed in this small series. In five cases high rates of somatic mutations were observed, with a predominance of mutations and replacements in CDR regions for three, indicating that these cells originate from cells that have been exposed to the hypermutation mechanism. The distribution of mutations in our small series provides some evidence of a selective mutational process.
An empirical examination of Wikipedia's credibility

Wikipedia is an free, online encyclopaedia which anyone can add content to or edit the existing content of. The idea behind Wikipedia is that members of the general public can add their own personal knowledge, anonymously if they wish. Wikipedia then evolves over time into a comprehensive knowledge base on all things. Its popularity has never been questioned, although its authority has. By its own admission, Wikipedia contains errors. A number of people have tested Wikipedia’s accuracy using destructive methods, i.e. deliberately inserting errors. This has been criticised by Wikipedia. This short study examines Wikipedia’s credibility by asking 258 research staff with a response rate of 21 percent, to read an article and assess its credibility, the credibility of its author and the credibility of Wikipedia as a whole. Staff were either given an article in their own expert domain or a random article. No difference was found between the two group in terms of their perceived credibility of Wikipedia or of the articles’ authors, but a difference was found in the credibility of the articles — the experts found Wikipedia’s articles to be more credible than the non–experts. This suggests that the accuracy of Wikipedia is high. However, the results should not be seen as support for Wikipedia as a totally reliable resource as, according to the experts, 13 percent of the articles contain mistakes.
Counting in High Density Crowd Videos

We propose a method for getting an estimate count of people in very high-dense crowd videos by extending a static crowd count method. Due to the challenging problem of perspective, occlusion, clutter, and low resolution counting by detection is not possible. Therefore, existing methods use dense features to get an estimate count. We propose using the extra information of motion in videos to construct a 3D Conditional Random Field to add the constraint that nearby patches (superpixels) should have a similar count and in the time dimension patches connected by trajectories should also have similar count. The method was tested on a dataset of 13 videos and compared to our previous method that estimates counts in images. Results of our method show a 4% improvement from the static crowd count method.
LDPC for Wi-Fi and WiMAX technologies

With increasing demand of low complexity, higher performance systems ITU adopted Wi-Fi and Wi-Max as one of the IMT 2000 Technologies. Wi-Fi and Wi-Max technologies are major global cellular wireless standards. IEEE 802.16e standards use LDPC (Low Density Parity Check) based SFN (Single Frequency Network) networks. These codes were introduced in 1962 by Gallager. LDPC codes for Wi-max and Wi-Fi is based on the set of one or more fundamental LDPC codes, each of which is systematic linear block codes. These codes can accommodate various code rates and packet sizes. LDPC with the help of high frequency powerful processors is error correcting codes which allows transmission at rates in close proximity to Shannon's limit for large block length. With this paper authors are describing various LDPC codes with low complexity and high performance used for Wi-Fi and Wi-max technologies.
Multicenter ophthalmic and nutritional age-related macular degeneration study--part 2: antioxidant intervention and conclusions.

BACKGROUND The experimental design, subjects, procedures and baseline data for the prospective double blind dry ARMD-antioxidant intervention study have been described in Part 1. METHODS At eight DVA medical centers, 32 patients (group one) were assigned a placebo and 39 patients (group two) a "broad spectrum" antioxidant capsule. Data was collected in five areas: demographic; ophthalmic; dietary analysis of daily food intake; serum analysis; and adverse gastrointestinal symptoms. Data was serially acquired at baseline, 6 months, 12 months and 18 months, and was analyzed by univariate repeated factors ANOVA, p = 0.05. RESULTS Group two (antioxidant po BID) maintained their distance LogMAR visual acuity (p = 0.03), while there was a trend toward both stabilized near M print (p = 0.07) and 6 cycle/degree contrast sensitivity (p approximately 0.10), in left eyes. However, group two (antioxidant) also had increased cortical opacification of the right lens (p = 0.04), compared to group one (placebo). Self perceived stabilization of vision was reported by subjects in group two and supported the objective data (Pearson chi square; p = 0.05). CONCLUSIONS A specific 14 component antioxidant capsule taken twice daily stabilized but did not improve dry ARMD over the study period of 1.5 years. The ARMD stabilized eyes had less advanced disease functionally but not by fundus appearance. Decreased intake of cardioprotective nutrients (vitamin E, zinc, magnesium, B6 and folate) in ARMD patients remained constant over the course of the trial.