Miracle-dz/UniFAR-FTUs huggingface dataset:
Treating Clinically Node-Negative Insular Thyroid Carcinoma without Prophylactic Central Compartment Neck Dissection Is Associated with Decreased Survival Regardless of T Staging and Administration of Radioactive Iodine Therapy: The First Evidence

For the rare but aggressive insular thyroid carcinoma (ITC), there's no clear evidence to determine whether prophylactic central compartment neck dissection (CCND) is necessary for cN0 disease. This study provides the first evidence that treating cN0 ITC without prophylactic CCND is associated with decreased survival regardless of T staging and administration of RAI therapy. Background. Regarding the rare but aggressive insular thyroid carcinoma (ITC), the value of prophylactic central compartment neck dissection (CCND) for clinically node-negative (cN0) disease is unclear. We aimed to provide the first evidence. Methods. N0 and pN1a ITC patients were identified from the Surveillance, Epidemiology, and End Results database. These patients were divided into thyroid-surgery + CCND group (pN0/pN1a patients confirmed by CCND) and thyroid-surgery group (cN0 patients without CCND). Differences in overall survival (OS) and disease-specific survival (DSS) between the two groups were evaluated. Subgroup analyses were also conducted. Results. Of the overall 112 patients, 44 (39.3%) received CCND. On multivariate analyses, the lobectomy ± isthmusectomy/total-thyroidectomy (Lob/TT) group demonstrated poorer OS and DSS than the Lob/TT + CCND group (P < 0.05). When we separately analyzed patients treated by TT, multivariate analyses showed the TT group still revealed compromised OS and DSS than the TT + CCND group (P < 0.05). Furthermore, absence of CCND independently predicted decreased OS no matter whether radioactive iodine (RAI) was administered. Similar results were obtained for T3/T4 patients. Moreover, for T1/T2 patients receiving CCND, 0/12 died during the study period, while for T1/T2 patients without CCND, 8/23 (34.8%) died, 5/23 (21.7%) due to ITC. Conclusion. Regardless of T staging and RAI treatment, cN0-ITC patients without CCND had decreased survival compared with pN0/pN1a patients receiving CCND. Therefore, if a cN0 patient is diagnosed with ITC, prophylactic CCND may be considered as a secondary procedure (postoperatively diagnosed) or a primary procedure (preoperatively/intraoperatively diagnosed). Prospective studies are expected to validate the conclusion.
Generation Y’s Work Values and Their Impact on the Hospitality Industry

In the current business environment, it is considered natural to see people from different generations working together. As it seems to be widely accepted that each generation has its own attributes that reflect in a unique manner on the way work is perceived, managers are being confronted with new challenges in managing human resources. As a result, the paper underlines the main differences between the three currently active generations on the labor market (Baby Boomers, generation X and generation Y) and their implications on the workplace. The main purpose of the article is to present bachelors’ of business administration perceptions of the factors considered important for an ideal workplace and whether the hospitality and tourism industry is able to offer these factors. Consequently, the paper brings forward an exploratory research, conducted using a questionnaire-based survey on 2015 bachelor graduates at the Faculty of Business and Tourism (Bucharest University of Economic Studies): out of the 320 students who have been enrolled in the senior year (2014-2015 academic year), 237 graduates completed the questionnaire. The results of the survey indicate that generation Y members’ most valued workplace characteristics are having promotion possibilities, working with people who cooperate effectively, having free time for personal life and having the opportunity of receiving high salary increases, as they advance in their career. These findings are compared to the conclusions of previous studies presented in the literature developed on this subject. The results of the study are relevant for the tourism industry as they reflect the needs and expectations of generation Y, therefore enabling managers to develop new human resources practices in order to attract and retain young graduates and determine them to become loyal, engaged employees. Considering the limitations of the research, the theoretical and practical implications of the findings are discussed.
Effect of sodium hydrogen sulfide (NaHS) on contrast-induced acute kidney injury; an experimental histopathological study

Introduction: Contrast-induced nephropathy (CIN) is associated with a minimum increase of 25% of the creatinine base or an increase in creatinine of 0.5 mg/dL during 2-3 days after the administration of the contrast agent Objectives: The present investigation was designed to examine the effect of sodium hydrogen sulfide (NaHS) on contrast-induced acute kidney injury in rats. Materials and Methods: Forty male Wistar rats randomly assigned into four groups, 10 rats for each group. Group 1; normal rats (control group; sham group); they did not receive any drugs. Group 2; rats were received 10 mL/kg as a single dose of iodixanol (contrast media) by intravenous (IV) injection. Group 3; they received 10 mg/kg of NaHS by intraperitoneal (IP) injection for three days, while in day forth, rats received a single dose of iodixanol (10 mL/kg). Group 4; rats of this group, first received a single dose of iodixanol (10 mL/kg). Then rats were treated by NaHS (10 mg/kg) by intraperitoneal (IP) injection for 3 days (days 2, 3 and 4). The kidneys were removed immediately after sacrificing and prepared for morphological examination. Kidney sections were examined for intensity of kidney damage by examination for degeneration, flattening, and necrosis of renal tubular cells and also dilatation of tubular lumen. Results: We detected a significant difference between groups regarding the morphologic variables of damage (P=0.001; one-way ANOVA). A significant difference of morphologic variables of damage (degeneration, flattening, necrosis, and dilatation) among the groups was seen too (P=0.001; one-way ANOVA). The study showed a significant difference between groups II (contrast media) with III (rats pretreated by NaHS) (P<0.001). Moreover, we detected a significant difference between groups II (contrast media) and IV (rats post-pone treated by NaHS) (P<0.001). However, there was not a significant difference between the groups of III and IV (P>0.05). Conclusion: Post-pone treatment of NaHS was as effective as the pretreatment to mitigate the renal damage induced by contrast media.
Poster: Limitations and Improvement of Dynimic Analysis Environment for Malware Analysis

Threats using malware are categorized as the most severe threat in the cyber space. Recent malwares are becoming more complex and elaborate to make the analysis difficult and over 50% are maintained undetected in anti-virus programs [1]. In this study, a new approach to increase the degree of completion for the dynamic analysis environment is to be presented based on the result of the verification on actually collected recent malwares, in regards to the theoretical techniques that make the analysis difficult.
FINANCIAL CRISES AND STRUCTURAL BREAKS IN AUTOCORRELATION ON THE BRICS’ STOCK MARKETS

The phenomenon of positive autocorrelation in daily stock index returns is often viewed as a consequence of stable behavioral patterns of certain investor groups (see e.g. Sentana and Wadhwani, 1992, Koutmos, 1997). However, such patterns may change due to extreme events, i.e. financial crises, and affect the autocorrelation of returns. Emerging markets have experienced severe crises in a recent decade and are therefore a suitable object to study.
A Comparative Study of Encryption Methods for Cloud Query Processing

Query cloud process is an interested research study that caught many researchers’ attentions. Several studies have presented different types of encryption in order to encrypt the data prior to being migrated over the cloud. However, there is an essential demand to balance between the time consumption and encryption security. This paper presented a comparative study of encryption methods for query execution over the cloud. Three common encryption methods have been used including Advanced Encryption Standard (AES), Rivest-Shamir-Adleman (RSA) and Elliptic Curve Cryptography (ECC). A benchmark dataset of queries has been used in the experiments. Based on the time of encryption and decryption along with the secrecy measure, the three methods have been evaluated. Results showed that RSA has the most competitive performance in terms of encryption and decryption time, meanwhile, it has a competitive secrecy measure values. It achieved an average encryption time of 0.57, 1.41 and 0.59 for Delete, Add and Select queries, as well as, it achieved an average decryption time of 2.31, 4.24 and 1.79 for Delete, Add and Select queries. Finally, RSA obtained an average secrecy of 1.10, 1.10 and 1.15 for Delete, Add and Select queries. This emphasis the usefulness of using RSA to maintain both efficiency and security of encryption.
Aurinkosähköjärjestelmien hintatasot ja kannattavuus

Aurinkosähköjärjestelmillä voidaan tuottaa paikallista ympäristöystävällistä energiaa. Kannattavimpia investoinnit ovat kiinteistöissä, joissa kuluu kesäaikana runsaasti sähköä. Esimerkiksi toimitilarakennuksissa aurinkosähkö vähentää ostosähkön määrää juuri silloin, kun rakennukset kuluttavat sähköä eniten ilmastointiin. Myös asukkaat voivat tehdä järkeviä investointeja aurinkosähköjärjestelmiin, mikäli tuotetun sähkön pystyy kuluttamaan itse.
The effectiveness of online parenting programmes in promoting parents’ and adolescents’ mental wellbeing: a systematic review protocol

Introduction: Emotional difficulties among young people are debilitating and increasing in prevalence. Parent focused interventions delivered online offer a convenient and potentially effective way to increase young people’s access to support. A systematic review offers the opportunity to assess their effectiveness and to identify characteristic of interventions which are particularly effective. Objective: To assess the existing online interventions for parents of young people that are designed to improve young people’s mental health and wellbeing. Methods: We will conduct a systematic review of randomised controlled trials identified through searching CENTRAL, Embase, MEDLINE, PsycINFO, and PubMed. We will follow Cochrane Handbook and involve at least two people in screening and data extraction. Risk of bias will be assessed using Cochrane risk of bias tool. We will use EndNote, Excel, and Review Manager for managing the studies and data. We will also apply TIDieR checklist to extract and summarise the specific characteristics of interventions. Protocol registration: PROSPERO CRD42018114921; registered on 31 October 2018.
Efecto de la enfermedad renal sobre el monitoreo ambulatorio de la presión arterial Effect of Renal Disease on Ambulatory Blood Pressure Monitoring

Background: Chronic renal disease is a growing public health problem, not only for its progression to end-stage renal failure but for its close association with cardiovascular disease, especially hypertension. Currently, there is scarce information on ambulatory blood pressure monitoring (ABPM) in hypertensive patients with renal failure. Objective: The aim of this study was to assess ABPM pulse pressure, circadian rhythm and blood pressure variability in a population of hypertensive patients with renal failure. Methods: A cross-sectional study evaluated 123 consecutive ABPM performed in a Hypertension Service. The glomerular filtration rate was estimated using the abridged formula from the “Modification of diet in renal disease” (MDRD) study. Results: A total of 123 hypertensive patients were evaluated (age 66±7.5 years, 56% men), whose glomerular filtration rate was 64.5±19.4 ml/min/1.73m 2 . Thirty-seven percent of patients presented with renal failure with a glomerular filtration rate of 45±12.5 ml/min/1.73m 2 vs. 76±11.9 ml/min/1.73m 2 in patients without renal failure. Fifty-five hypertensive patients (44%) had elevated pulse pressure: 28 (60.9%) with renal failure vs. 27 (35%) without renal failure (p<0.005). After adjusting for different variables, this difference remained significant. No differences were found in blood pressure variability or in the presence of non-dipper pattern. Conclusions: The main ABPM characteristic in hypertensive patients with renal failure was a significant increase of pulse pressure. There was no greater prevalence of non-dipper pattern or increased blood pressure variability, as classically described for the general population of renal disease patients.
Reduction of EMI Effects in Motor Drives and Complex Power Electronic Systems

This paper presents a systematic way to design optimal filters for line drivers and analog signal paths through modeling and simulation. The goal is to mitigate the effects of Electro-Magnetic Interference (EMI), particularly in an environment with high switching speed enabled by high bandwidth Silicon Carbide (SiC) and Gallium Nitride (GaN) semiconductor technologies. Frequency based analysis of EMI coupling between power and signal tracks, design of optimal low pass filters with maximum noise reduction and minimum signal delay, and efficient transient analysis to verify proper filter components are among the methods provided to optimally reduce the impact of EMI in motor drive and other power electronic applications.
EFFECT OF SALINITY, MOISTURE AND FARMYARD MANURE ON YIELD AND NITROGEN UPTAKE OF WHEAT PLANTS GROWN ON A CALCAREOUS SOIL.

A pot experiment was carried out in the green house of Soils and Water Department, Faculty of Agriculture, Al-Azhar University, during the winter of season (2009). The current work was carried out to study the effect of irrigation water salinity, farmyard manure levels and moisture content on the yield and nitrogen (content and uptake) of wheat grains of wheat plant grown on a calcareous soil. Wheat plant (Triticum aestivum, L.) Sakha93Variety, used as an indicator plant to experiment treatments. Four salinity levels of irrigation water were prepared (0.43 (Control), 1.56, 3.12 and 6.25 dSm -1 ) under different moisture contents (100%, 75% and 60%) of field capacity determined by weight and four organic matter levels (0% (control), 1%, 2% and 4%) farmyard manure(FYM). Twenty grains were sown in each pot and the treatments were three replicates including control. After 15 days, the pots were thinned to 10 seed lings. The obtained results showed that yield of both grains and straw, and nitrogen (content and uptake) in grains were significantly decreased with increasing salinity levels. Increasing of farmyard manure application rates up to 2% increased significantly yield of both grains and straw, and nitrogen (content and uptake) of grains. Yield of both grains and straw and nitrogen (content and uptake) of grains were significantly increased with increasing moisture levels regardless effect of salinity and farmyard manure.
Social Movements and Interest Groups Compared : How organisational type matters for explaining Swedish organisations’ advocacy strategies

The divide between interest groups and social movement studies runs deep, but present developments call for a renewed focus on the relevance of these analytical categories. Both of these two forms of collective action relate to organisations that are assumed to follow distinctive logics and strategies for political influence. This article aims to contribute to the debates on the analytical difference between interest groups and social movements by comparing their political strategies and addressing the relevance of the typology for explaining organisations' use of political strat-egies. The paper draws on a dataset resulting from a large survey among Swedish civil society organisations among which clear cases of interest group organisations and "old" and "new" social movement organisations (SMOs) were identified. The results show that the distinction between interest groups and social movement organisations has some analytical value when it comes to explaining the use of different types of strategies: e.g. direct lobbying and media-based and protest-based strategies. Also, the distinction between old and new SMOs is shown to be relevant because old SMOs seem to be in a way "in between" interest groups and new SMOs suggesting that social movements tend to develop over time and to become more similar to interest groups.
Differential metabolism of statins: importance in drug-drug interactions

3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is the key enzyme of cholesterol synthesis. HMG-CoA reductase inhibitors (statins) are potent, reversible inhibitors of this enzyme, which act by competing for the substrate, HMG-CoA. Six statins are now available: lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin, and cerivastatin. The differences in the chemical structures of these agents are responsible for major differences in their pharmacokinetic properties. Pravastatin, a hydrophilic drug, is not significantly metabolized by the cytochrome P450 (CYP450) system, unlike the other statins, which are lipophilic. This unique quality of pravastatin affects its metabolism, potential for drug interactions, and side effect profile, compared with the other agents. The pharmacokinetic properties of the statins and how they affect the use of these agents in clinical practice are described here.
PII: S0022-1694(00)00178-5

In this paper a relatively simple procedure is presented to construct a global river routing network on a 0.5 8 latitude– longitude grid. In this network all grid cells in a catchment are coupled and have a flow direction, making it a useful tool in the modeling of river flow on a global scale. The flow directions are based on a digital elevation model and on information on the locations of major rivers (‘stream burning’). The presented river routing network is specifically designed for the assessment of fresh water shortages. We tested the validity of the river routing network by comparing the computed drainage areas with published estimates. This comparison revealed a good similarity and it is concluded that the presented river routing network has sufficient quality to be implemented in global climate models. This could mean a considerable improvement of the surface parameterization in these models. q 2000 Elsevier Science B.V. All rights reserved.
Critical Care Nurse Specialists' Fee Development in South Korea

This study aimed to develop a nursing fee for advanced nursing practices done by critical care nurse specialists (CCNSs). The nursing fee for the 20 advanced nursing practices was calculated by multiplying the resource based relative value scale (RBRVS) of the each practice and the conversion factor. Most practices of CCNSs belonged to the category of less than 10,000 KRW. In order to improve efficient utilization of medical manpower in intensive care units, the employment of nurse specialists in hospitals is thought to have the national benefits.
Role of Degree Sequence in Determination of Maximal Clique of a Graph

The paper high lights the relation between Discrete Mathematics and Computer Science and Engineering. Since, Graphs and Graph-Algorithms are core topic in combinatorial Algorithms[6]. Our attempt is religious. This is a practice even adopted by D.E. Knuth[6] and shows that we are in a era where visual representation of graphs is a tertiary affair.
Successful treatment with lenalidomide plus chidamide combination therapy in 3 heavily treated patients with non-Hodgkin lymphoma

Abstract Rationale: The prognosis of patients with aggressive relapsed or refractory (R/R) non-Hodgkin lymphoma (NHL) remains poor. Both immunomodulatory drugs and histone deacetylase inhibitors have demonstrated activity against R/R NHL; yet, the combination of these 2 targeted therapies has rarely been explored. Patient concerns: Here, we report 3 cases. Case 1 was a 68-year-old woman who presented to our hospital with dyspnea. Case 2 was a 75-year-old man with massive upper gastrointestinal bleeding. Case 3 was a 62-year-old woman with cough, dyspnea, and lymphadenopathy. Diagnosis: The biopsy results revealed diffuse large B cell lymphoma (DLBCL), DLBCL, and angioimmunoblastic T-cell lymphoma, for Case 1, 2, and 3 respectively. Intervention: All 3 patients experienced relapse after first-line therapy and multiple lines of salvage therapy. Finally, they all received lenalidomide combined with chidamide. Outcomes: All 3 patients achieved complete and durable remission. Case 1 relapsed again after 3 months, while the other 2 cases remained in complete remission. Lessons: To our knowledge, this is the first report of lenalidomide combined with chidamide for the treatment of R/R NHL. Our findings warrant further evaluation of this novel chemo-free therapy in future prospective clinical trials.
The effect of cadmium loading on protein synthesis function and functional state of laying hens’ liver

In the article are considered issues related to the study of the effect of cadmium on the body of birds, in particular laying hens. The effect of cadmium sulfate at doses of 2.0 and 4.0 mg/kg body weight on protein synthesis function and functional state of the liver were investigated of cross-laying Hysex white hens, of 78 weeks old. Three groups of chickens were formed: two experimental and one control groups. The laying hens of the experimental groups were subjected to a cadmium load. Laying chickens of the first experimental group were given cadmium sulfate at a dose of 2.0 mg/kg body weight. Laying chickens of the second experimental group were given cadmium sulfate at a dose of 4.0 mg/kg body weight. Laying chickens in the control group were in the normal diet without cadmium. Increased activity of aminotransferases, in particular alanine and aspartate aminotransferases in their serum of hens, was observed during cadmium binge drinking in doses of 2.0 and 4.0 mg/kg body weight, respectively. These changes indicate a violation of the functional state of the liver of laying hens under conditions of cadmium load. In the study of protein synthesis of the liver of laying hens under conditions of cadmium loading, it was found that cadmium sulfate in the above doses contributed to a significant decrease in the level of total protein by 14, 21 and 30 days of the experiment. The reduction of total protein in the blood of laying hens was due to a decrease in the level of albumin, which in the second experimental group, respectively, decreased to 28.16 ± 0.75%, whereas in the first – 29.62 ± 0.98%. In the study of the level of globulins, it is possible to increase this indicator in both experimental groups of poultry for 21 days. Drinking with water cadmium sulfate at a dose of 4.0 mg/kg body weight was associated with a more likely decrease in total protein and albumin than drinking cadmium sulfate at a lower dose.
Performance Enhancement of Co Using 2-

The wireless communication is a very means of information sharing over air and sometimes it will benefits us to easy setup than wire line networks. Now lots of problems persists when distance between devices are quite longer than usual, and in such cases the signals got distorted to reach before receiving devices. For such kind of situation co networks came into existence. In this paper a wireless co operative mobile network is considered to enhance the performance using 2-PSK modulation schemes with different relaying modes like amplify and forward (AF), and decode and forward (DF) with different data sizes and iterations. The outcomes calculated in terms of bit error rate which is better than the existing co-operative mobile network. Keywords— Co-operative Mobile Network, 2-PSK Modulation, AF, DF.