Miracle-dz/UniFAR-FTUs huggingface dataset:
Wealth in Middle and Old Age in Mexico: The Role of International Migration 1

This article examines the impact that past migration to the U.S. has on the current economic well-being of individuals in middle or old age who have returned to Mexico. A priori, the net effect of U.S. migration on wealth among return migrants is difficult to predict; there are counteracting factors that can affect wealth positively or negatively. Using data from the Mexican Health and Aging Study 2001 and correcting for selection factors, the long-term effect of U.S. migration for return migrants was found consistently positive in terms of their accumulated personal wealth at middle and old age. This article speculates about the possible mechanisms that can explain this apparent advantage.
Hydatid cyst of the kidney. A report of 147 controlled cases.

OBJECTIVES We report our experience in the management of 147 hydatid cysts of the kidney over an 11-year period. MATERIAL AND METHODS The records of 147 patients operated for hydatid cysts of the kidney between 1985 and 1996 were reviewed in order to address patient's symptoms at presentation, radiological findings, diagnostic tests and surgical outcome. All patients were managed with open surgery. No preoperative or postoperative antiparasitic medication was used. RESULTS Lumbar or lumbo-abdominal pain was the most frequent symptom (84%). Hydaturia was observed in 28% of the cases. Preoperative diagnosis was based upon intravenous pyelography (IVP), ultrasound and serology tests. CT scan was performed only in litigating cases (15%). In 20 cases, damage to the renal parenchyma was so extensive as to justify nephrectomy. Abstention concerned 5 involutive type V cysts. The remaining patients had an excision of the prominent part of the cyst (partial cystopericystectomy). Postoperative course was smooth in all cases. Postoperative IVP (3-6 months) showed a restituo ad integrum in 80% of the cases and residual pelvicaliceal distortions in 20%. CONCLUSIONS Diagnosis of hydatid cyst of the kidney is based mainly on ultrasonography and IVP. Open surgery is the treatment of choice with excellent results.
Body composition in 13-year-old adolescents with abdominal obesity, depending on the BMI value.

BACKGROUND Excessive adipocyte growth during the pubertal transition predisposes to the development and persistence of obesity in adulthood. Visceral accumulation of body fat is particularly disadvantageous when it is correlated with insulin resistance, secondary hyperinsulinaemia, dysglicaemia, and atherogenic dyslipidemia. OBJECTIVES The aim of this study was to conduct a nutritional status assessment and body composition analysis in 13-year-old adolescents of both genders with visceral fat accumulation (WC ≥ 90th percentile) and different BMI values. MATERIAL AND METHODS The evaluation of state of nutrition of 1,738 Polish boys (n = 882) and girls (n = 856) aged 13 was done based on anthropometric measurements and calculated BMI (body mass index), WC (waist circumference) and WHtR indices (waist-to-height ratio). Taking into consideration the value of WC ≥ 90 pc, 353 people were designated (20.3 % of the total) with visceral obesity (but with various BMI), whose body composition was examined by the method of bioelectric impedance analysis (BIA). A total of 249 adolescents of both sexes (70.5% of the selected, 102 boys and 147 girls) and their parents agreed to the study. RESULTS In adolescents with visceral obesity a significant change of body content was ascertained depending on the value of the BMI. Even in the people with a proper value of the BMI, a significantly higher than standard increase of the percentage of total body fat (TBF) and decrease of both the percentage of body lean (BL) and the content of total body water (TBW) in the body was observed. The values of the BMI, WC and WHtR in adolescents were significantly correlated with each other as well as with TBF, BL and TBW, and the strength of correlation was dependent on sex. CONCLUSIONS The state of nutrition in adolescents with visceral obesity, even with a proper BMI, might contribute to the development of a metabolic syndrome.
Mortality and Resource Utilization After Critical Care Transport of Patients With Hypoxemic Respiratory Failure

Introduction: We performed this study to quantify resources required by mechanically ventilated patients with hypoxemia after critical care transport (CCT) and to assess short-term clinical outcomes. Methods: We performed a retrospective review of transports of patients with severe hypoxemic respiratory failure from referring hospitals to 3 tertiary care hospitals to assess the outcomes including in-hospital mortality, ventilator days, intensive care unit length of stay (LOS), hospital LOS, disposition, and reported neurologic status on hospital discharge as well as medical interventions specific to acute respiratory failure and critical care. Results: Of 230 patients transported with hypoxemic respiratory failure, 152 survived to hospital discharge, for a mortality rate of 34.5%, despite a predicted mortality of 64% by Acute Physiology and Chronic Health Evaluation II (APACHE II) score. Twenty-five percent of patients were treated with neuromuscular blockade, 10.1% received inhaled pulmonary vasodilators, and extracorporeal membrane oxygenation was initiated in 2.6%. Conclusions: In this cohort with hypoxemic respiratory failure transported to tertiary care facilities, patients had a mortality rate comparable to patients with acute respiratory distress syndrome treated with best practices and a mortality rate lower than predicted based on APACHE-II score. The risks of CCT are outweighed by the benefits of transfer to a tertiary care facility, and pretransport hypoxemia should not be used as an absolute contraindication to transport.
Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies B2M Inactivation Impairing Immunorecognition.

Purpose: We aimed to maximize the performance of detecting genetic alterations in lung cancer using high-throughput sequencing for patient-derived xenografts (PDXs). Experimental Design: We undertook an integrated RNA and whole-exome sequencing of 14 PDXs. We focused on the genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex.Results: We identified alterations in genes involved in various functions, such as B2M involved in immunosurveillance. We extended the mutational analysis of B2M to about 230 lung cancers. Five percent of the lung cancers carried somatic mutations, most of which impaired the correct formation of the HLA-I complex. We also report that genes such as CALR, PDIA3, and TAP1, which are involved in the maturation of the HLA-I complex, are altered in lung cancer. By gene expression microarrays, we observed that restitution of B2M in lung cancer cells upregulated targets of IFNα/IFNγ. Furthermore, one third of the lung cancers lacked the HLA-I complex, which was associated with lower cytotoxic CD8+ lymphocyte infiltration. The levels of B2M and HLA-I proteins correlated with those of PD-L1. Finally, a deficiency in HLA-I complex and CD8+ infiltration tended to correlate with reduced survival of patients with lung cancer treated with anti-PD-1/anti-PD-L1.Conclusions: Here, we report recurrent inactivation of B2M in lung cancer. These observations, coupled with the mutations found at CALR, PDIA3, and TAP1, and the downregulation of the HLA-I complex, indicate that an abnormal immunosurveillance axis contributes to lung cancer development. Finally, our observations suggest that an impaired HLA-I complex affects the response to anti-PD-1/anti-PD-L1 therapies. Clin Cancer Res; 23(12); 3203-13. ©2016 AACR.
Correlates of Cognitive Function in Middle-Aged Adults

The Atherosclerosis Risk in Communities Study administered cognitive function tests to more than 14,000 middle-aged adults in 1990–1992. The battery included the Delayed Word Recall test, the Digit Symbol Subtest of the Wechsler Adult Intelligence Scale-Revised, and the Controlled Oral Word Association (Word Fluency) test. Test performance was correlated positively with education level, negatively with age, was better in women than in men, and better in managers/professionals compared with other occupations. After controlling for these factors, race and community, the findings most consistent for both sexes were that Delayed Word Recall was negatively associated with depressive symptoms, diabetes, and fibrinogen level; the Digit Symbol Subtest was associated with marital status, negatively associated with depressive symptoms, smoking status, fibrinogen level, and carotid intima-media thickness, and positively associated with alcohol drinking and FEV1; and the Word Fluency test was positively associated with marital status, alcohol drinking, sports participation, and FEV1. Most of these cross-sectional results were in the predicted direction and have biologic plausibility, but mean differences between extreme categories were small (generally on the order of 0.1 to 0.2 of a standard deviation). Longitudinal study is warranted to evaluate whether small differences in middle-age lead to larger, clinically meaningful deficits with aging.
The Diabetes Disparity and Puerto Rican Identified Individuals

Purpose The purpose of this systematic review was to describe what is known about the diabetes disparity affecting Puerto Rican identified adults living in the continental United States as well as illuminate areas that merit further investigation. Methods The CINAHL and PubMed databases were searched using the keywords Hispanic, Puerto Rican, and type 2 diabetes. Search limits included < 10-year-old, peer-reviewed, systematic reviews, available in the English language. The abstracts of 124 articles were reviewed, and 7 articles were reviewed in depth. Results The Puerto Rican identified Hispanic subgroup is disproportionately affected by diabetes—the diabetes disparity. Puerto Rican identified Hispanic adults are less affected by citizenship status, may be less affected by English proficiency, use health care services differently, and have contextually different fatalistic views of diabetes compared with other Hispanic identified people. Spiritual/religious influences, associated mental health problems, and general cultural practices related to diabetes self-care are understudied in this group. Conclusion Ambiguous use of the term Hispanic should be avoided when describing Hispanic subgroups. Stronger, more robust studies are needed to understand the unique cultural forces influencing the poor diabetes outcomes and individual behaviors that contribute to generally suboptimal diabetes self-care for Puerto Rican adults with type 2 diabetes.
Infectious Disease and Imperfections of Self-Image

Infectious disease is an ever-present threat in daily life. Recent literature indicates that people manage this threat with a suite of antipathogenic psychological and behavioral defense mechanisms, which motivate the avoidance of people and objects bearing cues to pathogen risk. Here, we demonstrate that self-image is also impacted by these mechanisms. In seven studies, pathogen cues led individuals chronically averse to germs to express greater concern about their own physical appearance. Correspondingly, these people exhibited behavioral intentions and decisions intended to conceal or improve their appearance, such as purchasing facial products, taking pharmaceuticals, and undergoing cosmetic surgery. This work opens a new area of investigation for infectious-disease psychology research and highlights the central role played by physical appearance in pathogen-related cognition.
Engraftment Site and Effectiveness of the Pan-Caspase Inhibitor F573 to Improve Engraftment in Mouse and Human Islet Transplantation in Mice

Background Islet transplantation is an effective therapy in type 1 diabetes and recalcitrant hypoglycemia. However, there is an ongoing need to circumvent islet loss posttransplant. We explore herein the potential of the pan-caspase inhibitor F573 to mitigate early apoptosis-mediated islet death within portal and extrahepatic portal sites in mice. Methods Mouse or human islets were cultured in standard media ±100 &mgr;M F573 and subsequently assessed for viability and apoptosis via terminal deoxynucleotidyl transferase dUTP nick end labeling staining and caspase-3 activation. Diabetic mice were transplanted with syngeneic islets placed under the kidney capsule (KC) or into the subcutaneous deviceless (DL) site at a marginal islet dose (150 islets), or into the portal vein (PV) at a full dose (500 islets). Human islets were transplanted under the KC of diabetic immunodeficient mice at a marginal dose (500 islet equivalents). Islets were cultured in the presence of F573, and F573 was administered subcutaneously on days 0 to 5 posttransplant. Control mice were transplanted with nontreated islets and were injected with saline. Graft function was measured by nonfasting blood glucose and glucose tolerance testing. Results F573 markedly reduced human and mouse islet apoptosis after in vitro culture (P < 0.05 and P < 0.05, respectively). Furthermore, F573 improved human islet function when transplanted under the KC (P < 0.05); whereas F573 did not enhance murine islet marginal KC transplants. Conversely, F573 significantly improved mouse islet engraftment in the PV and DL site (P < 0.05 and P < 0.05, respectively). Conclusions The pan-caspase inhibitor F573 markedly reduces human and mouse islet apoptosis and improves engraftment most effectively in the portal and DL subcutaneous sites.
A low power cybersecurity mechanism for WSNs in a smart grid environment

Smart Grid cybersecurity is one of the key ingredients for successful and wide scale adaptation of the Smart Grid by utilities and governments around the world. The implementation of the Smart Grid relies mainly on the highly distributed sensing and communication functionalities of its components such as Wireless Sensor Networks (WSNs), Phasor Measurement Units (PMUs) and other protection devices. This distributed nature and the high number of connected devices are the main challenges for implementing cybersecurity in the smart grid. As an example, the North American Electric Reliability Corporation (NERC) issued the Critical Infrastructure Protection (CIP) standards (CIP-002 through CIP-009) to define cybersecurity requirements for critical power grid infrastructure. However, NERC CIP standards do not specify cybersecurity for different communication technologies such as WSNs, fiber networks and other network types. Implementing security mechanisms in WSNs is a challenging task due to the limited resources of the sensor devices. WSN security mechanisms should not only focus on reducing the power consumption of the sensor devices, but they should also maintain high reliability and throughput needed by Smart Grid applications. In this paper, we present a WSN cybersecurity mechanism suitable for smart grid monitoring application. Our mechanism can detect and isolate various attacks in a smart grid environment, such as denial of sleep, forge and replay attacks in an energy efficient way. Simulation results show that our mechanism can outperform existing techniques while meeting the NERC CIP requirements.
CARACTERIZAÇÃO DA EXTRAÇÃO DE ETANOL DE SOLUÇÕES HIDROALCOÓLICAS POR ARRASTE COM CO2

RESUMO No presente estudo foram avaliadas as principais variaveis envolvidas na remocao de etanol a partir a de uma solucao hidroalcoolica empregando CO2 como gas de arraste. Para avaliar a influencia das variaveis de processo no arraste foi realizado um planejamento composto central rotacional (DCCR), variando a vazao especifica de CO2, a concentracao inicial de etanol e a temperatura solucao. Como variaveis de resposta para o planejamento experimental, foram obtidos os valores das constantes de velocidade de remocao de etanol (kE) e de agua (kW). A partir da analise estatistica do planejamento experimental foi possivel obter o modelo empirico para as variaveis resposta kE e kW e as curvas de contorno em funcao das variaveis estudadas (, CE e T). Os resultados indicam que a vazao especifica de CO2 foi a variavel que apresentou maior efeito sobre as respostas analisadas.
Some Mechanical Properties of Lower Lip Movement During Speech Production

Abstract In an attempt to describe the mechanical properties of lower lip movement during speech production, EMG activity from the orbicularis oris inferior and depressor labii inferior muscles was observed along with jaw-independent movement of the lower lip in the inferior-superior dimension. A simple analog computer was employed to aid in the determination of this EMG movement transfer function. The results of the analysis suggested that one predominant mechanical limitation on lower lip movement in the inferior-superior dimension is the viscosity of muscle contraction, which varies most directly with the rate of active muscle shortening. There was also evidence of an elastic component which acted, in part, as an energy storage element to return the lip to the closure position.
Ultra Low-Dose IL-2 for GVHD Prophylaxis after Allogeneic Hematopoietic Stem Cell Transplantation Mediates Expansion of Regulatory T Cells without Diminishing Antiviral and Antileukemic Activity

Purpose: GVHD after allogeneic hematopoietic stem cell transplantation (alloSCT) has been associated with low numbers of circulating CD4+CD25+FoxP3+ regulatory T cells (Tregs). Because Tregs express high levels of the interleukin (IL)-2 receptor, they may selectively expand in vivo in response to doses of IL-2 insufficient to stimulate T effector T-cell populations, thereby preventing GVHD. Experimental Design: We prospectively evaluated the effects of ultra low-dose (ULD) IL-2 injections on Treg recovery in pediatric patients after alloSCT and compared this recovery with Treg reconstitution post alloSCT in patients without IL-2. Sixteen recipients of related (n = 12) or unrelated (n = 4) donor grafts received ULD IL-2 post hematopoietic stem cell transplantation (HSCT; 100,000–200,000 IU/m2 ×3 per week), starting <day 30 and continuing for 6 to 12 weeks. Results: No grade 3/4 toxicities were associated with ULD IL-2. CD4+CD25+FoxP3+ Tregs increased from a mean of 4.8% (range, 0%–11.0%) pre IL-2 to 11.1% (range, 1.2%–31.1%) following therapy, with the greatest change occurring in the recipients of matched related donor (MRD) transplants. No IL-2 patients developed grade 2–4 acute GVHD (aGVHD), compared with 4 of 33 (12%) of the comparator group who did not receive IL-2. IL-2 recipients retained T cells reactive to viral and leukemia antigens, and in the MRD recipients, only 2 of 13 (15%) of the IL-2 patients developed viral infections versus 63% of the comparator group (P = 0.022). Conclusions: Hence, ULD IL-2 is well tolerated, expands a Treg population in vivo, and may be associated with a lower incidence of viral infections and GVHD. Clin Cancer Res; 20(8); 2215–25. ©2014 AACR.
Cigarette Smoke-Induced Lipid Peroxidation in Human Skin and Its Inhibition by Topically Applied Antioxidants

Cigarette smoke, whether indirect or direct stream, is an environmental pollutant which presents an increasing health problem. In order to determine damage to human skin at the biochemical level, volar forearms were exposed to cigarette smoke for fifteen minutes and then assayed for the presence of stratum corneum lipid peroxides. A time-dependent increase was observed over a 24-hour post-exposure period. At 24 h, the average baseline level of lipid peroxides was 14.9 nmol/unit area of skin as compared to 32.0 nmol/unit area of skin for the smoke-exposed arms. In addition, when topical antioxidants were pre-applied to the skin and then exposed to cigarette smoke, an average decrease of 40.9% in lipid peroxide values was observed. These data demonstrate that peroxidation was induced in human skin by cigarette smoke and subsequently inhibited by the presence of antioxidants.
Progress toward norovirus vaccines: considerations for further development and implementation in potential target populations

Human norovirus infection causes significant medical and financial costs in the USA and abroad. Some populations, including young children, the elderly, and the immunocompromised, are at heightened risk of infection with this virus and subsequent complications, while others, such as healthcare workers and food handlers are at increased risk of transmitting it, and some are at risk of both. Human noroviruses are heterogeneous with new strains emerging periodically. In addition to viral diversity, incompletely understood characteristics, such as virus–host cell binding and duration of immunity after infection add to the challenges of creating a norovirus vaccine. Although much progress has been made in recent years, many questions remain to be answered. In this review, we discuss the important areas and relevant literature in considering human norovirus vaccine development and potential targets for implementation.
Control of chaotic systems with disturbances using LMI-based twisting-like algorithm

This paper proposes a chaos control scheme for stabilizing chaotic systems in the presence of external disturbances. The scheme is based on a twisting-like algorithm, which consists of a state feedback control law and the twisting algorithm (TA). The TA is one of the promising high-order sliding-mode control algorithms. The Lyapunov direct method is utilized to derive a sufficient stability condition. The condition is formulated in a Linear Matrix Inequality (LMI) form and therefore is readily solved. The Lorenz system with an external disturbance is used as a demonstrative example. Numerical results illustrate the effectiveness of the proposed control scheme.
Quantitative Measures of Gait Characteristics Indicate Prevalence of Underlying Subclinical Structural Brain Abnormalities in High-Functioning Older Adults

Abnormal gait in high-functioning older adults may indicate underlying subtle structural brain abnormalities. We tested the hypothesis that temporal and spatial parameters of gait, including speed, stride length and double support time, are cross-sectionally associated with white matter hyperintensity, subcortical infarcts or brain atrophy on brain MRI. We examined 321 men and women (mean age = 78.3) participating to the Cardiovascular Health Study who were free of dementia or stroke at the time of the gait assessment. Analyses were set with gait as independent variable and brain MRIs as dependent variables. Gait measures were determined from the footfalls recorded on a 4-meter-long instrumented walking surface, the GaitMat II. Brain MRIs were examined for the presence of white matter hyperintensity (WMG, graded from 0 to 9), brain infarcts (predominantly subcortical) and ventricular enlargement (graded from 0 to 9). Slower gait, shorter stride length and longer double support times were associated with greater prevalence of white matter grade ≧3 (p = 0.02), and at least 1 brain infarct (p = 0.04) independent of age. In multivariate logistic regression models adjusted for demographics and clinical cardiovascular diseases, those with gait speed <1.02 m/s were more likely to have WMG ≧3 and at least 1 brain infarct, compared with those with faster gait – odds ratio (OR): 2.85, 95% confidence interval (95% CI): 1.35, 6.02, and OR: 2.09, 95% CI: 1.04, 4.19. Shorter stride length was also associated with greater probability of having at least 1 brain infarct (gait stride <0.88 vs. >1.10 m: OR: 3.20, 95% CI: 1.49, 6.88), while longer double support times were associated with a greater probability of having WMG ≧3 (double support time >0.19 vs. <0.14 s: OR: 2.3, 95% CI: 1.1, 4.7) independent of demographics and clinical cardiovascular diseases. Gait parameters were not significantly associated with ventricular grade. In summary, in this group of high-functioning older adults, poorer gait speed, shorter stride and longer double support time are associated with high white matter disease and subclinical strokes.