Miracle-dz/UniFAR-FTUs huggingface dataset:
Identifier la cible des émotions dans les forums de santé

Les forums de sante en ligne sont des espaces d'echanges ou les patients partagent leurs sentiments a propos de leur(s) maladie(s), traitement(s), etc. Sous couvert d'anonymat, ils expriment tres librement leurs experiences personnelles. Ces forums sont donc une source d'informations tres utile pour les professionnels de sante afin de mieux identifier et comprendre les problemes, les comportements et les sentiments de leurs patients. Dans le cadre du projet Patients' mind, nous nous interessons a l'analyse semi-automatique de ces forums et plus particulierement, dans cet article, a la recherche des cibles des emotions exprimees par les patients. Nous proposons une methode originale pour identifier ces cibles, basee sur la notion de roles semantiques et utilisant la ressource FrameNet. Notre methode a ete validee avec succes sur un jeu de donnees reelles.
Standards for Children's Height at Ages 2-9 Years Allowing for Height of Parents

Charts are presented which give centile standards for boys' and girls' heights at ages 2 to 9 when parents' height is allowed for. Mid-parent height is used (i.e. the average of father's and mother's height). A comparison is made with results from the existing `parent-unknown' British standard charts. A child at the 3rd centile on the parent-unknown charts is (i) at the 20th centile on the new charts if his parents are small enough to average 3rd centile for adults, (ii) at about the 1st centile if his parents average the 97th centile. Conversely a child with 97th centile parents has only to be at the 25th centile for the population in the parent-unknown charts to be at the conventional 3rd centile limit of normal when parental height is allowed for. Thus the new standards result in considerably increased precision. Examples are given of normal boys with small parents who plotted outside the 3rd centile on the conventional charts but inside on the present charts. The differential diagnosis of genetic small stature is made considerably more straightforward by the use of these charts. The correlation coefficients are given at successive ages, from 1 month to 9 years, for child's supine length or height with mid-parent height and for mother-daughter, mother-son, father-daughter, and father-son relationships.
Securing Cranial Horizontal-Vertical Valve in Proper Orientation for Use in Ventriculoperitoneal Shunting: Technical Note

Introduction: There are several options for cerebrospinal fluid diversion in patients with normal pressure hydrocephalus. Fixed and programmable valves, with or without anti-siphon devices, have been used for ventriculoperitoneal shunts and horizontal-vertical valves for lumboperitoneal shunts. Recently, a horizontal-vertical valve was developed for ventriculoperitoneal shunts and has been demonstrated to be efficacious. This series describes the surgical method we employ for securing the valve in a true vertical position. Materials and Methods: The bone of the retroauricular region above the superior nuchal line is exposed. A trough is made in the bone in the vertical orientation to seat the valve which is then secured with a titanium plate and screw. Results: The technique has been used without complications in nine patients to date. No patient has exhibited signs of shunt malfunction. Conclusion: The authors propose this method for the safe, secure maintenance of an horizontal-vertical valve used for ventriculoperitoneal shunting in the upright vertical position.
Vectorial mapping of resonant THz near-fields

We use photo-conductive micro-probe tips to demonstrate full vectorial mapping of the complex electric near-field in the vicinity of resonant structures at THz frequencies. We further show that characterization of these structures based on far-field spectroscopy can be indeterministic. Hence, there is a necessity to use near-field techniques for the accurate characterization of THz resonators.
Galaxy formation through cosmic recycling

Direct observations reveal how massive galaxies formed in the early universe Extremely massive galaxies are seen in the young universe, but their presence is puzzling because we do not yet understand how they became so massive so quickly. How do they get enough fuel to form stars so rapidly? The raw fuel for forming stars is cold molecular gas, and although this gas is common within young galaxies (1), we do not know how it is replenished once the first reservoirs are converted into stars. On page 1128 of this issue, Emonts et al. (2) report observations that may provide our first clue to this fueling problem. They have detected a giant reservoir of recycled molecular gas that is replenishing the fuel supply of one of the most massive galaxies in the young universe.
Malignant transformation and life expectancy in monoclonal gammopathy of undetermined significance

The actuarial probability of malignant transformation and the impact on expected survival were analysed in a series of 128 persons diagnosed with monoclonal gammopathy of undetermined significance (MGUS) over a 20‐year period. At a median follow‐up of 56 months the M‐component remains stable in 101 patients (78·9%), 14 patients (10·9%) have died from non‐related disorders and 13 (10·2%) have developed malignant transformation of MGUS (multiple myeloma, 10; primary amyloidosis, two; Waldenström's macroglobulinaemia, one). The actuarial probability of malignant transformation at 5 and 10 years was 8·5% and 19·2%, respectively. When different presenting features were analysed for predictive value of the malignant transformation, the IgA type of MGUS was the only variable associated with a higher probability of such an event (P<0·025). Although no significant difference was observed between the survival probability of persons with MGUS and that of the control population, the development of malignant transformation was associated with a shorter survival (P<0·001).
Schizophrenia and smoking: evidence for a common neurobiological basis?

Several previous investigations have suggested that the gene for the alpha 7-nicotinic receptor may play a role in the pathogenesis of schizophrenia and may be responsible for the heavy smoking among schizophrenic patients. In a study of 129 healthy controls and 127 schizophrenic, schizoaffective, and bipolar patients we have aimed 1) to confirm the potential association between schizophrenia and the alpha 7-nicotinic receptor, 2) to test the diagnostic specificity of alpha 7-receptor subunits with respect to psychiatric diagnoses, and 3) to investigate potential receptor differences between smokers and nonsmokers in the general population. Our analysis included the two dinucleotide polymorphisms D15S1360 and L76630 that are localized in a genomic fragment containing the alpha 7-nicotinic receptor gene CHRNA7. Highly significant differences (P < 0.0001) between the allele distributions of patients and controls were detected for these two markers with all three diagnostic subgroups contributing to the discrimination. An independently ascertained replication sample of 24 patients confirmed this finding. Our results suggested an unspecific vulnerability that depended on the severity of overall psychopathology in terms of the co-occurrence of psychopathology with no clear-cut boundary between the diagnostic entities. In comparison with healthy controls, this vulnerability was lowest among schizophrenics, intermediate among bipolars, and highest among schizoaffectives. As to the question of alpha 7-receptor differences between smokers and nonsmokers among the healthy control subjects, our analysis revealed no significant differences, thus indicating that the differences between patients and controls are more than just a smoker/nonsmoker distinction. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:173-177, 2000.
Resource management of switches and Controller during saturation time to avoid DDoS in SDN

Software Defined Network abbreviated as SDN is a new paradigm which is transforming the existing network into a real time dynamic and programmable network. The logically centralized nature of SDN supports the emerging network architecture with many features such as centralized control of the network by decoupling the control plane and data plane thus enabling a global view of the network. It provides network programmability regardless of the device infrastructure and simplifies the control, but at the same time it is exposed to many vulnerabilities that does not persist in the proposed architecture. The Control plane bandwidth and the time out value of the flow rule have direct impact on the controller's computational efficiency, thus Controller is exposed to attack. An Attacker can saturate the control plane bandwidth and switch flow table by sending bogus packet request continuously which increases the latency and can lead to distributed denial of service (DDoS). In this paper, we propose a feasible method to control the saturation of path between the control and the data plane which is the key to carry out the network functionalities in an efficient manner by handling the request based on priority and the flow rule is configured in context to the peak time.
Histone genes and histone messengers.

PERSPECfIVES AND SUMMARY . INTRODUCfION . HISTONE GENE ORGANIZATION . General Features . The Special Case 01 L Pictus . �O:;�:: �:::;�cd;;�� . ·:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: Drosophila Melanogaster . Chromomeric localization . Cloned Drosophila histone genes . Histone Genes 01 Other Species . Genetic Polymorphism in Sea Urchin Histone Genes . DNA SEQUENCES OF HISTONE GENES . General Features . Fine Structure . Codon ass ilf'lments . Amino acid sequences . Leader and trailer sequence comparisons . Leader and trailer sequence homologies . Homogeneity 01 Histone Gene Sequences Within Species . HISTONE mRNAs . Identification . Histone template activity . mRNA sequence analysis . Homology with cloned histone genes . +12027
Current and future role of MR enterography in the management of Crohn disease.

OBJECTIVE The purpose of this article is to explore the future role of MRI in assessing the global disease burden of Crohn disease and monitoring treatment response. CONCLUSION MR enterography is increasingly used to evaluate disease activity in Crohn disease, and scoring methods have been validated. Current MRI protocols may be extended to allow the assessment of inflammation and fibrosis.
Reduction of torque ripple and increase of torque capacity of BLDC motor

This paper uses the idea of increasing the phases of Brushless DC motors (BLDC motors) with the purpose of Performance improvement of this motors. At first, a new model for the drive of 9-phase BLDC motor is studies. This model is simulated and run by Matlab/Simulink software. Then, the obtained results including Steady-state and transient characteristics, are compared with the results of 3, 5 and 7-phase models. The results of comparison show the advantages of increasing number of phases of BLDC motor, including considerable reduction of torque ripple, increase of starting torque and partial improvement in motor efficiency.
N‐glycosylation status of β‐haptoglobin in sera of patients with colon cancer, chronic inflammatory diseases and normal subjects

N‐glycosylation status of purified β‐haptoglobin from sera of 17 patients, and from sera of 14 healthy volunteer subjects, was compared by blotting with various lectins and antibodies. Patients in this study were diagnosed as having colon cancer through histological examination of each tumor tissue by biopsy. Blotting index of serum β‐haptoglobin with Aleuria aurantia lectin (AAL) was clearly higher for cancer patients than for healthy subjects. No such distinction was observed for blotting with three other lectins and two monoclonal antibodies. To determine tumor‐associated reactivity of AAL binding as compared to inflammatory processes in colonic tissues, β‐haptoglobin separated from sera of 5 patients with Crohn's disease (CD), and 4 patients with ulcerative colitis (UC), was studied. All these cases, except one case of UC, showed AAL index lower than that in cancer cases, similarly to healthy subjects. The higher AAL binding of β‐haptoglobin in colon cancer patients than in healthy subjects appeared to be due to α‐L‐fucosyl residue, since it was eliminated by bovine kidney α‐fucosidase treatment. N‐linked glycans of serum haptoglobin from colon cancer patients vs. healthy subjects were released by N‐glycanase, fluorescence‐labeled, and subjected to normal‐phase high performance liquid chromatography (NP‐HPLC). Glycan structures were determined based on glucose unit (GU) values and their changes upon sequential treatment with various exoglycosidases. Glycosyl sequences and their branching status of glycans from 14 cases of serum β‐haptoglobin were characterized. The identified glycans were sialylated or nonsialylated, bi‐antennary or tri‐antennary structures, with or without terminal fucosylation.
Double burden of iron deficiency in infancy and low socioeconomic status: a longitudinal analysis of cognitive test scores to age 19 years.

OBJECTIVE To assess change in cognitive functioning after iron deficiency in infancy, depending on socioeconomic status (SES; middle vs low). DESIGN Longitudinal study. SETTING Urban community in Costa Rica (infancy phase [July 26, 1983, through February 28, 1985] through 19-year follow-up [March 19, 2000, through November 4, 2002]). PARTICIPANTS A total of 185 individuals enrolled at 12 to 23 months of age (no preterm or low-birth-weight infants or infants with acute or chronic health problems). The participants were assessed in infancy and at 5, 11 to 14, 15 to 18, and 19 years of age. A total of 97% were evaluated at 5 or 11 to 14 years and 78% at 15 to 18 or 19 years. Individuals who had chronic iron deficiency in infancy (iron deficiency with hemoglobin concentrations < or =10.0 g/dL or, with higher hemoglobin concentrations, not fully corrected within 3 months of iron therapy) were compared with those who had good iron status as infants (hemoglobin concentrations > or =12.0 g/dL and normal iron measures before and/or after therapy). MAIN OUTCOME MEASURES Cognitive change over time (composite of standardized scores at each age). RESULTS For middle-SES participants, scores averaged 101.2 in the group with chronic iron deficiency vs 109.3 in the group with good iron status in infancy and remained 8 to 9 points lower through 19 years (95% confidence interval [CI], -10.1 to -6.2). For low-SES participants, the gap widened from 10 points (93.1 vs 102.8; 95% CI for difference, -12.8 to -6.6) to 25 points (70.4 vs 95.3; 95% CI for difference, 20.6 to 29.4). CONCLUSIONS The group with chronic iron deficiency in infancy did not catch up to the group with good iron status in cognitive scores over time. There was a widening gap for those in low-SES families. The results suggest the value of preventing iron deficiency in infancy.
TMC125 Displays a High Genetic Barrier to the Development of Resistance: Evidence from In Vitro Selection Experiments

ABSTRACT TMC125 is a potent new investigational nonnucleoside reverse transcriptase inhibitor (NNRTI) that is active against human immunodeficiency virus type 1 (HIV-1) with resistance to currently licensed NNRTIs. Sequential passage experiments with both wild-type virus and NNRTI-resistant virus were performed to identify mutations selected by TMC125 in vitro. In addition to “classic” selection experiments at a low multiplicity of infection (MOI) with increasing concentrations of inhibitors, experiments at a high MOI with fixed concentrations of inhibitors were performed to ensure a standardized comparison between TMC125 and current NNRTIs. Both low- and high-MOI experiments demonstrated that the development of resistance to TMC125 required multiple mutations which frequently conferred cross-resistance to efavirenz and nevirapine. In high-MOI experiments, 1 μM TMC125 completely inhibited the breakthrough of resistant virus from wild-type and NNRTI-resistant HIV-1, in contrast to efavirenz and nevirapine. Furthermore, breakthrough of virus from site-directed mutant (SDM) SDM-K103N/Y181C occurred at the same time or later with TMC125 as breakthrough from wild-type HIV-1 with efavirenz or nevirapine. The selection experiments identified mutations selected by TMC125 that included known NNRTI-associated mutations L100I, Y181C, G190E, M230L, and Y318F and the novel mutations V179I and V179F. Testing the antiviral activity of TMC125 against a panel of SDMs indicated that the impact of these individual mutations on resistance was highly dependent upon the presence and identity of coexisting mutations. These results demonstrate that TMC125 has a unique profile of activity against NNRTI-resistant virus and possesses a high genetic barrier to the development of resistance in vitro.
TRIZ, ASIT, CK Connections and Disconnections between Three Major Theoretical Frameworks on Creativity

This paper intend to propose a comparative analysis of three major theoretical framework engineers and creative companies frequently use. All of them propose to help users to break psychological walls hiding creative solutions. Beyond the individual preferences and the mimesis effect, studying what is the DNA, often fruit of the History of Europe, behind these theories and analyzing how they are or not connected allows us to understand how we come to the future society of knowledge.
High in situ rat intestinal permeability of artemisinin unaffected by multiple dosing and with no evidence of P-glycoprotein involvement.

The objective of this study was to investigate whether the decrease in artemisinin bioavailability after repeated oral dosing in humans can be a result of increased efflux of artemisinin by P-glycoprotein or decreased membrane transport at the intestinal barrier. The effective jejunal permeability (Peff) of artemisinin was investigated using an in situ rat perfusion model. Fifty-four rats were randomized to one of three treatment arms: no pretreatment, pretreatment with artemisinin emulsion for 5 days (60 mg/kg/day, p.o. ), or pretreatment with emulsion vehicle for 5 days. The rats within each treatment arm were randomized further to be jejunally perfused with either low (500 ng/ml) or high (5000 ng/ml) artemisinin concentration or low artemisinin concentration plus the P-glycoprotein inhibitor R,S-verapamil (400 microg/ml). Perfusate samples were assayed for content of artemisinin, R,S-verapamil, and perfusion viability markers. Artemisinin Peff was 1.44 +/- 0.38, 1. 17 +/- 0.32, and 1.71 +/- 0.29 (.10(-4), cm/s) in rats receiving no pretreatment and perfused with low, high, or low artemisinin concentration plus verapamil, respectively. Multiple oral dosing of artemisinin did not affect the jejunal permeability of artemisinin. R,S-verapamil Peff was similar in artemisinin-pretreated rats (1.09 +/- 0.54. 10(-4), cm/s) and rats pretreated with only vehicle (1.07 +/- 0.37. 10(-4), cm/s). The decrease in artemisinin bioavailability after multiple oral dosing in human is probably not a result of changes in P-glycoprotein expression or general intestinal transport. It seems more likely attributed to increased hepatocellular activity. Furthermore, artemisinin exhibits high jejunal permeability and is neither a substrate nor inducer of P-glycoprotein.
An investigation into SMEs’ use of languages in their export operations

This paper reports on an exploratory investigation into the use of languages within UK small and medium‐sized enterprises (SME) which are engaged in export activities. Results from a postal survey and subsequent interviews provide a contribution to the literature by reporting on empirical findings in relation to four areas: managers’ perceived importance and benefits of using foreign languages, issues preventing their use, the functional use of languages within businesses and issues affecting firms’ recruitment and training in respect of languages. The results suggest that, although most firms are aware of the importance of languages and the benefits they can bring, this is not reflected in their use in certain functional areas and within the recruitment and training policies of many businesses.
Therapeutic failure in pneumonia caused by a tolerant strain of Staphylococcus aureus.

AbstractA 24-year-old woman acquired a Staphylococcus aureus pneumonia during an influenza A infection. The disease progressed despite treatment with cloxacillin. The staphylococcal strain isolated was found to be tolerant to the bactericidal activity of cloxacillin. Clinical improvement was seen with gentamicin in combination with cefuroxime.
A novel architecture for fast 2D IDCT decoders, with reduced number of multiplications

This paper presents a new architecture for the fast computation of the 8×8 two dimensional (2D) Inverse Discrete Cosine Transform (IDCT). The key idea of the proposed method is the permanent storage of the Basis Matrices of the 8×8 2D Discrete Cosine Transform (DCT). By exploiting the sparseness property of the 2D DCT coefficient matrix, the computational time decreases as the number of nonzero coefficients decreases. Moreover, by exploiting the symmetry properties inherent in the Basis Matrices, the introduced method reduces the number of multipliers as well as the number of required multiplications. The proposed structure computes all 64 pixel luminance values of an 8×8 block simultaneously. The efficiency of the proposed architecture is validated through simulations.
Group Intervention to Reduce HIV Transmission Risk Behavior Among Persons Living With HIV/AIDS

Results of a randomized controlled trial show that a behavioral intervention grounded in social cognitive theory reduces unprotected sexual behaviors among men and women living with HIV infection, with the greatest reductions in HIV transmission risk behaviors occurring with non-HIV-positive sex partners. In this article, the authors describe the intervention development and intervention content of the social cognitive risk reduction intervention for HIV-positive persons. The effective five group session intervention focused on enhancing motivation through self-reflection and developing coping efficacy skills for HIV disclosure decision making, active listening, assertiveness, and problem solving for disclosure and transmission risk reduction behaviors. Intervention components were tailored for gender and sexual orientation and integrated skills practice sessions used role-plays couched within scenes from popular films. This intervention was demonstrated to be effective in a community-service delivery setting and can be adapted for implementation in HIV-related services delivered within support groups.