Miracle-dz/UniFAR-FTUs huggingface dataset:
Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization.

Three mitogen-activated protein (MAP) kinase family members have been identified in mammalian cells that are activated by cellular stresses, by bacterial lipopolysaccharide, and by the cytokines interleukin-1 and tumor necrosis factor and have therefore been called stress-activated protein kinases (SAPKs). SAPK1, SAPK2A (also known as p38, RK, and CSBP), and SAPK2B are activated by upstream kinases and in turn phosphorylate downstream substrates, such as other protein kinases and a number of transcription factors. 12 refs., 1 fig.
Mixed bacterial and viral infections are common in children

Acute phase and convalescent sera from 51 pediatric patients who had a documented viral infections and no obvious culture-confirmed bacterial infection such as meningitis, otitis media or urinary tract infection were tested by enzyme immunoassay for antibodies to Haemophilus influenzae and Branhamella catarrhalis and by the latex agglutination test for pneumococcal antigens to evaluate the frequency of mixed bacterial and viral infections. A mixed bacterial and viral infection was documented in 19 patients (37%). Seven patients (14%) showed a diagnostic rise in antibodies to H. influenzae and 8 patients (16%) showed an antibody elevation to B. catarrhalis in their
Recurrent Saccharomyces cerevisiae fungemia in an otherwise healthy patient.

was 40°C, blood pressure 90/60 mmHg and heart rate 110 beats per minute. Neck rigidity and diffuse abdominal tenderness were noted, together with mild hepato-splenomegaly. Laboratory tests revealed leukopenia of 2200 cells/µl with a left shift and 87% neutrophils. The hemoglo-bin was 12.9 g/dl and mean corpuscular volume 77 fl. Erythrocyte sedimentation rate was 28 mm. Mild elevation was found in aspartate aminotransferase (57 U/L) and alanine aminotransferase (48 U/L). Lumbar puncture revealed normal cere-brospinal fluid, glucose and protein, without cells. CSF culture was sterile. Chest X-ray was normal. Urinalysis showed 3–4 leukocytes and 6–9 erythrocytes in high power field. Multiple blood cultures and a urine culture were obtained, as were viral and bacterial serologic tests. Intravenous fluids with metoclo-pramide and papaverine were administered. Her temperature dropped to 38°C and she reported marked relief from her headache and abdominal pain. Leukocyte count increased up to 5500 cells/µl, and ALT and AST values normalized. On the fourth day, urine culture revealed growth of Escherichia coli and Enterobacter, both sensitive to quinolones. Ofloxacin was given orally, 400 mg a day. The next day, we were informed about the growth of yeasts in five of nine blood cultures taken earlier. Intravenous fluconazole was started, 400 mg a day. Abdominal ultra-sonography and computed tomography demonstrated hepatosplenomegaly with a small effusion surrounding the gallbladder and a moderate amount of pelvic fluid. CSF = cerebrospinal fluid ALT = alanine aminotransferase AST = aspatate aminotransferase For editorial see page 561 F ungal diseases are relatively uncommon and occur mostly in immune-compromised patients. Saccharomyces cerevisiae is one of the less common fungal pathogens and rarely causes disease in humans. We report a case of recurrent fungemia caused by the yeast in an otherwise healthy patient. Patient descriPtiOn A 35 year old woman was admitted in March 2004 with sudden onset of high grade fever, chills, headache, nausea and abdominal pain. Her past medical history was relevant for recurrent vaginal bleeding 3 years earlier, related to arteriovenous malformations located in the uterus, uter-ine cervix and proximal part of the vagina. Hemostatic sutures for bleeding lesions, angiographic embolizations of the uter-ine arteries and local radiotherapy to the pelvis failed to stop the bleeding, necessitating transabdominal hysterectomy and upper vaginectomy. During one of the bleeding episodes, an intrauterine device was sought but not found. Explorative laparotomy was performed but failed to reveal the device. On admission, the patient looked severely ill, …
Role of canstatin in early fibrotic lesions of idiopathic interstitial pneumonias and migration of lung fibroblasts

Early fibrotic lesions are thought to be one of the initial findings of lung fibrogenesis in idiopathic interstitial pneumonias, but little is known about their properties. Canstatin is an endogenous angiogenesis inhibitor derived from the C-terminal globular non-collagenous domain of the α2 chain of type IV collagen, and type IV collagen is deposited in early fibrotic lesions without neovascularization in usual interstitial pneumonia (UIP). We used immunohistochemical methods to study expression of canstatin in lung specimens from patients with UIP or organizing pneumonia (OP). We analyzed the expression and function of canstatin in cultured lung fibroblasts by Western blotting and a Boyden chamber migration assay. We found expression of canstatin in early fibrotic lesions of UIP but not OP. Lung fibroblasts showed enhanced expression of canstatin after being stimulated with transforming growth factor-b1. Recombinant canstatin inhibited migration of not only endothelial cells but also lung fibroblasts. These results suggest that fibroblasts in early fibrotic lesions of UIP, which express canstatin, have less ability to migrate than fibroblasts in OP lesions, which do not express canstatin. Thus, canstatin in early fibrotic lesions of UIP contributes to persistent fibrogenesis and is likely involved in its refractory nature, including migration of intralesional fibroblasts.
Superfamily Member LIGHT T Cell Function in Mice Lacking the TNF + Cutting Edge: Selective Impairment of CD8

Interactions of LIGHT and its receptors, herpesvirus entry mediator on T cells and lymphotoxin (cid:2) receptor on stromal cells, are implicated in the regulation of lymphoid organogenesis, costimulation of T cells, and activation of dendritic cells. In this work we report that LIGHT-deﬁcient mice had normal lymphoid organs with T cells and APCs that normally re-sponded to Ag stimulation and normally stimulated T cells. Although the number of V (cid:2) 8 (cid:1) T cells in naive LIGHT (cid:1) / (cid:1) and LIGHT (cid:3) / (cid:3) mice was identical, V (cid:2) 8 (cid:1) CD8 (cid:1) T cell proliferation in response to staphylococcal enterotoxin B was signiﬁcantly lower in LIGHT (cid:3) / (cid:3) mice. Consistently, induction and cytokine secretion of CD8 (cid:1) CTL to MHC class I-restricted peptide was also reduced in LIGHT (cid:3) / (cid:3) mice. However, the proliferative response of V (cid:2) 8 (cid:1) CD4 (cid:1) T cells to staphylococcal enterotoxin B was comparable in LIGHT (cid:3) / (cid:3) and LIGHT (cid:1) / (cid:1) mice. Our results suggest that LIGHT is required for activation of normal CD8 (cid:1) T cells but not CD4 (cid:1) T cells. The Journal of Immunology, 2002, 168: 4832–4835. EL4E7 cells (2 (cid:4) 10 5 cells/ml). EL4E7, a human papillomavirus-16 E7-transduced EL4 lym-phoma cell incubation CTL activity against EL4 and EL4E7 by the standard 4-h 51 Cr release assay (16). In the supernatants during collected from days to and cytokines by speciﬁc sandwich
Electronic compass sensor

In this paper, we describe a new two respective three axis integrated IMC Hall-ASIC that can be used as a single chip electronic compass and applied in portable low cost electronic equipment like wrist watches and mobile phones. The electronic compass chip consists of ring shaped integrated ferromagnetic concentrators (IMC), a CMOS integrated circuit and an excitation coil manufactured by direct bonding onto the chip surface. The IMC Hall ASIC measures the two in-plane magnetic field components Bx and By and the vertical component Bz of the Earth's magnetic field. The IMC Hall sensor exhibits an excellent sensitivity of 8000 V/T for the X and Y axis which yields an in-plane heading accuracy of +/-1/spl deg/, whereas the field in the Z-axis is measured with a lower sensitivity of 800 V/T. The high sensitivity characteristics are obtained by integrating magnetic flux concentrators directly on the Hall-ASIC, which amplifies the Earth's magnetic field by a factor of 10. Furthermore, the compass sensors provides a low energy method to eliminate the perming effect (remnant field effect after subjecting to strong magnetic fields).
illingness of future A / H 7 N 9 influenza vaccine uptake : A ross-sectional study of Hong Kong community mily

We conducted a population telephone survey in Hong Kong during the second wave of influenza A/H7N9 outbreak in 2014. Among the respondents, 50.5% of the respondents would like to accept A/H7N9 vaccination in future. Respondents had poor knowledge of A/H7N9 influenza and vaccines. More than 60% of respondents mixed up seasonal influenza this year and A/H7N9 influenza. Results show that sociodemographic factors were all independent of the vaccine uptake willingness while anxiety level and eywords: nfluenza /H7N9 accine andemic preparedness vaccine history were the main affecting factors. Vaccine promotion strategies may focus on influenza knowledge, attitude and behavior. © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Rates of new or missed colorectal cancers after colonoscopy and their risk factors: a population-based analysis.

BACKGROUND & AIMS The rate of new or missed colorectal cancer (CRC) after colonoscopy and their risk factors in usual practice are unknown. Our objective was to evaluate the rate and risk factors in a population-based study. METHODS We analyzed data from the Canadian Institute for Health Information, the Ontario Health Insurance Program, and Ontario Cancer Registry for all patients (> or =20 years of age) with a new diagnosis of right-sided, transverse, splenic flexure/descending, rectal or sigmoid CRC in Ontario from April 1, 1997 to March 31, 2002, who had a colonoscopy within the 3 years before their diagnosis. Patients with new or missed cancers were those whose most recent colonoscopy was 6 to 36 months before diagnosis. We examined characteristics that might be risk factors for new or missed CRC. RESULTS We identified a diagnosis of CRC in 3288 (right sided), 777 (transverse), 710 (splenic flexure/descending), and 7712 (rectal or sigmoid) patients. The rates of new or missed cancers were 5.9%, 5.5%, 2.1%, and 2.3%, respectively. Independent risk factors for these cancers in men and women were older age; diverticular disease; right-sided or transverse CRC; colonoscopy by an internist or family physician; and colonoscopy in an office. CONCLUSIONS Because having an office colonoscopy and certain patient, procedure, and physician characteristics are independent risk factors for new or missed CRC, physicians must inform patients of the small risk (2% to 6%) of these cancers after colonoscopy. The influence of type of physician and setting on the accuracy of colonoscopy, potentially modifiable risk factors, warrants further study.
Medical Specialists’ Patient-Centered Communication and Patient-Reported Outcomes

Background:Physicians’ patient-centered communication in the medical consultation is generally expected to improve patient outcomes. However, empirical evidence is contradictory so far, and most studies were done in primary care. Objective:We sought to determine the association of specialists’ patient-centered communication with patient satisfaction, adherence, and health status. Methods:Residents and specialists in internal medicine (n = 30) and their patients (n = 323) completed a questionnaire before a (videotaped) follow-up encounter. Patients’ satisfaction was assessed immediately after the consultation and their self-reported treatment adherence, symptoms, and distress 2 weeks later. Specialists’ patient-centered communication was assessed by coding behaviors that facilitate or rather inhibit patients to express their perspective. Patient participation was assessed by determining their relative contribution to the conversation and their active participation behavior. Outcomes were assessed using standard questionnaires. Analyses accounted for relevant patient, visit and physician characteristics. Results and Conclusions:Medical specialists’ facilitating behavior was associated with greater satisfaction in patients who were less confident in communicating with their doctor. Patient-centered communication was not associated with patients’ health status or adherence in general, but facilitating behavior was positively related to the adherence of patients with a foreign primary language. In general, patients appeared to be more satisfied after an encounter with a more-facilitating and a less-inhibiting physician, but these associations diminished when controlling for background characteristics. We conclude that the absence of strong associations between patient-centered communication and patient-reported outcomes may be explained by medical specialists being responsive to patients’ characteristics.
Autonomic markers in patients with diabetes

OBJECTIVE—Diabetic postinfarction patients are at increased mortality risk compared with nondiabetic postinfarction patients. In a substantial number of these patients, diabetic cardiac neuropathy already preexists at the time of the infarction. In the current study we investigated if markers of autonomic dysfunction can further discriminate diabetic postinfarction patients into lowand high-risk groups.
Developmental psychopathology and public health: Past, present, and future

Children's healthy mental development has never been the focus of long-term, committed public health policy in the way that early physical health and development have been. We discuss four types of societal response to illness—cure, care, control, and prevention—and trace the history of public health in terms of its special responsibility to control and prevent disease. We identify four periods in the history of public health: the Sanitarian era (up to 1850), the Bacterial era (1850–1950), the Behavioral era (1950–present), and the Communitarian era (the next century). Looking at this history from the viewpoint of the developmental psychopathology of the first 2 decades of life, we trace progress in public health responses to children with mental illness, from a philosophy of control by isolation toward one of preventive intervention. We examine primary, or universal, prevention strategies that have been tried, and we suggest some that might be worth reconsidering.
A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

We identified a serine/threonine protein kinase that is associated with and phosphorylates phosphoinositide 3-kinase (PtdIns 3-kinase). The serine kinase phosphorylates both the 85- and 110-kDa subunits of PtdIns 3-kinase and purifies with it from rat liver and immunoprecipitates with antibodies raised to the 85-kDa subunit. Tryptic phosphopeptide maps indicate that p85 from polyomavirus middle T-transformed cells is phosphorylated in vivo at three sites phosphorylated in vitro by the associated serine kinase. The 85-kDa subunit of PtdIns 3-kinase is phosphorylated in vitro on serine at a stoichiometry of approximately 1 mol of phosphate per mol of p85. This phosphorylation results in a three- to sevenfold decrease in PtdIns 3-kinase activity. Dephosphorylation with protein phosphatase 2A reverses the inhibition. This suggests that the association of protein phosphatase 2A with middle T antigen may function to activate PtdIns 3-kinase.
A CONDIÇÃO PÓS-HUMANA: OU COMO PULAR SOBRE NOSSA PRÓPRIA SOMBRA

Qual seria o fundamento da natureza humana? Uma resposta a essa questao parece estar pressuposta num determinado leque de abordagens teoricas que afirmam que as novas tecnologias de digitalizacao da vida nos conduzem a um tipo particular de sociabilidade, a uma ruptura com o humano, a uma condicao pos-humana. No artigo que se segue pretendo fornecer subsidios teoricos que possam instrumentar uma reflexao acerca de determinados projetos de ruptura com a tradicao humanista. Meu impulso inicial para empreender tal tarefa foi dado por dois ensaios curtos: Regras para um Parque Humano, de Peter Sloterdijk, e Carta sobre o Humanismo, de Martin Heidegger. O texto conclui que nao existe nada mais metafisico que tentativas de dar um salto para fora da metafisica e do humanismo. Palavras-chave: Humanismo. Pos-humanismo. Modernidade. Natureza Humana.
Roots of the Second Green Revolution

The Green Revolution boosted crop yields in developing nations by introducing dwarf genotypes of wheat and rice capable of responding to fertilisation without lodging. We now need a second Green Revolution, to improve the yield of crops grown in infertile soils by farmers with little access to fertiliser, who represent the majority of third-world farmers. Just as the Green Revolution was based on crops responsive to high soil fertility, the second Green Revolution will be based on crops tolerant of low soil fertility. Substantial genetic variation in the productivity of crops in infertile soil has been known for over a century. In recent years we have developed a better understanding of the traits responsible for this variation. Root architecture is critically important by determining soil exploration and therefore nutrient acquisition. Architectural traits under genetic control include basal-root gravitropism, adventitious-root formation and lateral branching. Architectural traits that enhance topsoil foraging are important for acquisition of phosphorus from infertile soils. Genetic variation in the length and density of root hairs is important for the acquisition of immobile nutrients such as phosphorus and potassium. Genetic variation in root cortical aerenchyma formation and secondary development (‘root etiolation’) are important in reducing the metabolic costs of root growth and soil exploration. Genetic variation in rhizosphere modification through the efflux of protons, organic acids and enzymes is important for the mobilisation of nutrients such as phosphorus and transition metals, and the avoidance of aluminum toxicity. Manipulation of ion transporters may be useful for improving the acquisition of nitrate and for enhancing salt tolerance. With the noteworthy exceptions of rhizosphere modification and ion transporters, most of these traits are under complex genetic control. Genetic variation in these traits is associated with substantial yield gains in low-fertility soils, as illustrated by the case of phosphorus efficiency in bean and soybean. In breeding crops for low-fertility soils, selection for specific root traits through direct phenotypic evaluation or molecular markers is likely to be more productive than conventional field screening. Crop genotypes with greater yield in infertile soils will substantially improve the productivity and sustainability of low-input agroecosystems, and in high-input agroecosystems will reduce the environmental impacts of intensive fertilisation. Although the development of crops with reduced fertiliser requirements has been successful in the few cases it has been attempted, the global scientific effort devoted to this enterprise is small, especially considering the magnitude of the humanitarian, environmental and economic benefits being forgone. Population growth, ongoing soil degradation and increasing costs of chemical fertiliser will make the second Green Revolution a priority for plant biology in the 21st century.
Color image analysis using fuzzy set theory

An application of fuzzy set theory to the color image analysis is presented in this paper. It is developed to inference the weather state from a color image. For a color image, its RGB components are first converted into HSI components. For each component, a 3-layer quadtree is created for image analysis. Then the histogram of each block image from the top layer to bottom layer is computed. The histogram is further converted into a membership function by using the scheme of a 6-parameter fuzzy number. The fuzzy inference for the given image is thus achieved by using the generated membership functions.
Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations

BACKGROUND Despite growing evidence that bariatric/metabolic surgery powerfully improves type 2 diabetes (T2D), existing diabetes treatment algorithms do not include surgical options. AIM The 2nd Diabetes Surgery Summit (DSS-II), an international consensus conference, was convened in collaboration with leading diabetes organizations to develop global guidelines to inform clinicians and policymakers about benefits and limitations of metabolic surgery for T2D. METHODS A multidisciplinary group of 48 international clinicians/scholars (75% nonsurgeons), including representatives of leading diabetes organizations, participated in DSS-II. After evidence appraisal (MEDLINE [1 January 2005–30 September 2015]), three rounds of Delphi-like questionnaires were used to measure consensus for 32 data-based conclusions. These drafts were presented at the combined DSS-II and 3rd World Congress on Interventional Therapies for Type 2 Diabetes (London, U.K., 28–30 September 2015), where they were open to public comment by other professionals and amended face-to-face by the Expert Committee. RESULTS Given its role in metabolic regulation, the gastrointestinal tract constitutes a meaningful target to manage T2D. Numerous randomized clinical trials, albeit mostly short/midterm, demonstrate that metabolic surgery achieves excellent glycemic control and reduces cardiovascular risk factors. On the basis of such evidence, metabolic surgery should be recommended to treat T2D in patients with class III obesity (BMI ≥40 kg/m2) and in those with class II obesity (BMI 35.0–39.9 kg/m2) when hyperglycemia is inadequately controlled by lifestyle and optimal medical therapy. Surgery should also be considered for patients with T2D and BMI 30.0–34.9 kg/m2 if hyperglycemia is inadequately controlled despite optimal treatment with either oral or injectable medications. These BMI thresholds should be reduced by 2.5 kg/m2 for Asian patients. CONCLUSIONS Although additional studies are needed to further demonstrate long-term benefits, there is sufficient clinical and mechanistic evidence to support inclusion of metabolic surgery among antidiabetes interventions for people with T2D and obesity. To date, the DSS-II guidelines have been formally endorsed by 45 worldwide medical and scientific societies. Health care regulators should introduce appropriate reimbursement policies.
THE NEW INSTITUTIONAL ECONOMICS

© Association of Christian Economists he New Institutional Economics provides a framework for understanding the interaction of government structures, firm organization, and individual decisions, emphasizing transaction costs as a central component of economic activity. This article briefly reviews the Old Institutional Economics and its decline and then describes the New Institutional Economics which incorporate some of the earlier institutional concerns into a framework more closely connected to mainstream economics. It concludes with some implications for Christian economists.