Miracle-dz/UniFAR-FTUs huggingface dataset:
180‐kD bullous pemphigoid antigen/type XVII collagen: Tissue‐specific expression and molecular interactions with keratin 18

The 180‐kD bullous pemphigoid antigen (BPAG2) is a hemidesmosomal transmembrane protein, also known as type XVII collagen. In this study, potential interactions of BPAG2 with other proteins expressed in epidermal keratinocytes were explored by yeast two‐hybrid system using the amino‐terminal intracellular domain of BPAG2 as a bait. Several independent interacting clones encoding keratin 18 (K18) were identified when the keratinocyte cDNA library, cloned into the yeast two‐hybrid activation domain vector, was screened. The peptide sequence responsible for the interaction of BPAG2 was restricted to amino acids 15–25, and substitution of a valine residue in the middle of this sequence by a proline (V23P) by site‐directed mutagenesis abolished the interaction. Further examination of the K18 sequences by restricted cDNA constructs in yeast two‐hybrid system identified a carboxyl‐terminal segment corresponding to helix 2B domain as critical for BPAG2 binding. The interaction of BPAG2/K18 was confirmed by an in vitro protein‐protein interaction assay, which also confirmed that normal human keratinocytes express K18 in culture. The tissue specific expression of BPAG2 was first examined using a multi‐tissue RNA blot. Human multiple tissue cDNA panels representing a variety of adult and fetal tissues as well as tumor cells were used as PCR‐templates to study the expression patterns of both BPAG2 and K18. The results demonstrated significant level of expression of BPAG2, besides in epidermal keratinocytes, also in a variety of tissues with predominant epithelial component, such as mammary, salivary and thyroid glands, colon, prostate, testis, placenta, and adult and fetal thymus, as well as in colon, pancreatic and prostatic adenocarcinoma cell lines, and an ovarian carcinoma. As expected, K18 transcript is present in liver, pancreas, colon, placenta, and in fetal kidney. Collectively, the results suggest that BPAG2 has a relatively broad tissue distribution including specialized and simple epithelia, and that within the tissues such as colon and placenta, BPAG2 may have direct interactions with K18, a keratin characteristically expressed in a simple epithelia. J. Cell. Biochem. 72:356–367, 1999. © 1999 Wiley‐Liss, Inc.
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sels, there are many different forms of trunk of Henle. Variations are documented in our series, and no similar pattern was observed among 111 dissections. Even the classic description of the Henle was not encountered in this study. The most common type of trunk of Henle is seen as a gastro-pancreatico-colic trunk (GPCT) with participation of the right gastro-omental vein, anterior superior pancreatico-duodenal veins, and any colic vein. The colic veins run parallel to other veins that participate with the trunk of Henle in the natural position. During the full mobilization of the right side of the colon, inappropriate traction of the mesocolon creates tension on the colic veins and the tributaries of the trunk of Henle (Fig. 1). This may tear any of these colic veins at the attachment point to the GPCT and may result in serious life-threatening bleeding. To the Editor–As a result of our large cadaveric dissection study, we concluded that normal vascular variations for each vessel of the right colon do not exist, and venous anomalies are especially more common. Thus, it is not possible for 1 person to have exactly the same vascular pattern as another person. Surgeons may encounter this complex vascular anatomy at some stage of surgery. Hence, preoperative evaluation of not only the clinical stage of the cancer but also of the vascular anatomic evaluation of the colon is very useful, especially during complete mesocolic excision with central vascular ligation. Moreover, preoperative radiologic information and the knowledge of these vascular variations are of paramount importance for both removal of the lymphatic tissue around the superior mesenteric vein (SMV) and avoiding serious bleeding complications. The most critical field of surgery is near the pancreatic notch where the trunk of Henle forms. Venous anomalies are more common at this point, and this area is called the bleeding point. According to the participating gastric, pancreatico-duodenal, and colic ves4. Ignjatovic D, Stimec B, Finjord T, Bergamaschi R. Venous anatomy of the right colon: three-dimensional topographic mapping of the gastrocolic trunk of Henle. Tech Coloproctol. 2004;8:19–21.
Informational role of options and the interrelation between stock and option markets

Viele Modelle zur Bewertung von Finanzinstrumenten basieren auf der Annahme, dass alle im Markt agierenden Investoren uber denselben Informationsstand verfugen. Empirische Studien haben jedoch gezeigt, dass Informationen ungleich unter Marktteilnehmern aufgeteilt sind. Das fuhrt dazu, dass es Investoren gibt die einen Informationsvorsprung besitzen, welchen sie versuchen bestmoglich auszunutzen um ihren erwarteten Profit zu maximieren. Die Existenz heterogen verteilter Informationen beeinflusst die Preisfindung und Informationseffizienz des Marktes. Diese Arbeit untersucht die Verarbeitung und Ubertragung von Informationen in Aktien- und Optionsmarkten und welche Auswirkungen das Vorhandensein von Investoren, die uber Insiderinformationen verfugen, auf das Zusammenwirken der beiden Markte hat. Die Grundhypothese dieser Arbeit ist, dass informierte Investoren bevorzugt Optionen anstatt der zugrundeliegenden Aktien handeln. Es wird angenommen, dass der Hebel, welchen Optionen bieten, den informierten Investoren einen hoheren Profit ermoglicht, ungeachtet der geringeren Liquiditat und den hoheren Handelskosten in Optionsmarkten. Es wird erwartet, dass Investoren mit positiven Informationen uber die zugrundeliegende Aktie bevorzugt out-of-the-money Call Optionen und Investoren mit negativen Informationen out-of-the-money Put Optionen kaufen. Wenn ein Handel in Optionsmarkten auf Grund eines Informationsvorsprungs einiger Investoren stattfindet, hat das zur Folge, dass neue Informationen zuerst von Optionen wiedergespiegelt werden. Demzufolge wird in dieser Arbeit unterstellt, dass es moglich ist, mit aktuellen Optionspreisen zukunftige Aktienpreise zu bestimmen. Diese Annahme wird in dieser Arbeit anhand von Lead-Lag Regressionen uberpruft. Die verwendeten Optionsdaten beziehen sich auf Optionen, die an der CBOE gehandelt werden, und die zugrundeliegenden Aktienwerte auf Aktien, die an der NYSE gelistet sind.
Game-theory Model based on Carrier Sense Multiple Access Protocol in Wireless Network

In order to solve game-theory model problem based on carrier sense multiple access protocol with collision avoidance in wireless network, a game-theory-based general and compatible modeling process is proposed, where the transmission probability of a node in a slot time is regarded as mixed game and network performance parameter M is taken as revenue function of game so as to build M rounds non-cooperative mixed strategy game with N gamers. After performing M rounds game, it will acquire M Nash-equilibria which is not equal to each other, and then these Nash-equilibria are taken as the input of single objective programming model with many constraints so as to obtain compromise equilibria. Finally, a minimum contention window based on compromise equilibria is designed. The throughput and successful transmission rate are analyzed through the simulation, and the simulation experiment results show our proposed modeling process has the more throughputs and the lower drop performance than the existing methods.
Organizational Context and Information Systems Success: A Contingency Approach

Abstract:Previous research suggests that organizational factors can be as important as individual factors for the success of information systems. This paper proposes a contingency approach relating selected organizational factors, namely organizational size, maturity, resources, time frame, and IS sophistication to user satisfaction and system usage. The model is tested through an empirical investigation of 34 small and medium-sized manufacturing firms. Data analysis results indicate that while organizational time frame and is sophistication have a direct effect upon satisfaction and usage, the effect of size, maturity, and resources is mediated by IS sophistication
Notes on clitics in Dutch

22, 1992. Thanks are due to the organizers and participants of this workshop. The presentation of this paper in Lund made it impossible for me to attend Eric Reuland's farewell party. Therefore, this paper is dedicated to him, in grateful recognition of his unrelenting efforts to bring out the best in his students. I wish him the best of everything in Utrecht. For this paper in particular, I also want to thank Judy Bernstein, Anna Cardinaletti, Liliane Haegeman, Aaron Halpern, Eric Hoekstra, Jan Koster, and Toshifusa Oka. NOTES ON CLITICS IN DUTCH
Learning Image Representations to Understand and Predict Semantic Hierarchies

Humans are very good at recognizing and labeling seen objects at different levels of the semantic hierarchy. If a human is not sure about what particular breed of dog she sees, she would just recognize it as a dog, the finest label she is confident about. To get closer to general human visual recognition especially with fewer training data and on images from unseen classes, we hypothesize that designing deep neural network architectures to learn representations which lend themselves to predictions at different levels is a crucial stepping stone. We defined a novel hierarchical object classification task where a model should be able to predict the most fine-grained label that the model is confident about. To tackle this task, we investigated several model architectures and proposed a chained convolutional and recurrent neural net architecture (CNN-RNN) as shown in Figure 1. We evaluated our models on the CIFAR-100 dataset of color images, each of which belongs to one of 100 fine-grained classes and one of 20 coarse-grained superclasses.
O capitalismo imperialista e a esfera político-midiática: a sujeição da mídia ao imperialismo e sua influência nas Relações Internacionais

A crescente influencia da midia no cenario internacional torna-se cada vez mais clara. Tal processo ocorre paralelamente a expansao dos principais meios de comunicacao e de seu dominio dentro do mercado midiatico que e, em grande parte, fruto da concentracao que acompanha tal expansao. Em consequencia disso, a midia global transformou-se em um poderoso oligopolio, que influi sobre diferentes acoes do Sistema Internacional. O presente artigo busca mostrar a relacao entre o capitalismo imperialista contemporâneo e o setor midiatico e qual a relevância desta associacao para a conjuntura social, politica e economica tanto de uma perspectiva brasileira quanto global. Para essa analise foram utilizados textos de importantes autores que escreveram sobre o estagio imperialista do capitalismo e sobre temas a este relacionados, tais como Lenin, Hobson, Hilferding e List.
Early origin and deep conservation of enhancers in animals

Transcription factors (TFs) bind DNA enhancer sequences to regulate gene transcription in animals. Unlike TFs, the evolution of enhancers has been difficult to trace because of their rapid evolution. Here, we show enhancers from the sponge Amphimedon queenslandica can drive cell type-specific reporter gene expression in zebrafish and mouse, despite sponge and vertebrate lineages diverging over 700 million years ago. Although sponge enhancers, which are present in both highly conserved syntenic gene regions (Islet–Scaper, Ccne1–Uri and Tdrd3–Diaph3) and sponge-specific intergenic regions, have no significant sequence identity with vertebrate genomic sequences, the type and frequency of TF binding motifs in the sponge enhancer allow for the identification of homologous enhancers in bilaterians. Islet enhancers identified in human and mouse Scaper genes drive zebrafish reporter expression patterns that are almost identical to the sponge Islet enhancer. The existence of homologous enhancers in these disparate metazoans suggests animal development is controlled by TF-enhancer DNA interactions that were present in the first multicellular animals. One-sentence summary Enhancer activity is conserved across 700 million years of trans-phyletic divergence.
Excitonic Effects in Single Layer MoS2 Probed by Broadband Two-dimensional Electronic Spectroscopy

We exploit two-dimensional electron spectroscopy to coherently excite the A and $\mathrm{B}$ excitons in monolayer Mos2. Combined with simulations, our data distinguish ultrafast bright excitons decoherence and sub-ps scattering decays to dark excitons. OCIS codes 300.6530. © 2019 The Author(s)
Improved quadratic boost converter using switching coupled-inductor and voltage-doubler

ABSTRACT A novel high voltage gain non-isolated boost converter based on the normal quadratic boost converter topology is introduced. In the referenced circuit, a powerful charging capacitor can power the switched inductor. In the proposed topology, this inductor is improved using a coupled-inductor. The primary part of the coupled-inductor takes the place of the switched inductor and the secondary part is laid in the output side. A voltage-doubler is combined with the secondary part to increase the voltage gain and reduce oscillations during operations. The main advantage of this topology is that it has a high voltage gain and it can be controlled by both the duty cycle of the switch and the turns ratio of the coupled-inductor. The voltage stress on the switch and capacitors is relatively low, while the efficiency is high, over 90%, which is quite necessary in practical situations. This converter is designed to operate in the continuous-current mode and the boundary condition mode is also analysed. Mathematical derivations of operations and power losses and software-based simulation results can provide main features of this topology. Hardware test results can demonstrate the potential utility in both industrial and domestic areas.
Kawaii meiru and Maroyaka neko: Mobile emoji for relationship maintenance and aesthetic expressions among Japanese teens

Drawing from the results of focus group interviews conducted between 2006 and 2010 in Japan, this paper examines the functions of emoji . Now that emoji have gained global recognition as seen in mobile applications, examining the way Japanese teens use emoji offers some insight into the way emoji use is practiced among teens in the global cultural context. The results highlight two functions of emoji in the context of mobile interactions: emoji allow Japanese teens to manage communication climate as well as to construct and express their aesthetic selves. Further research is needed to investigate to what extent these interaction norms, symbolic meanings, and electronic emotions are applicable to various cultural contexts in the era of smart phones. Such efforts will promote our further understanding of both current and future trends of teens’ mobile emoji use, emotional experiences, sense of the self, and relational concerns.
A geometric atlas to predict lung tumor shrinkage for radiotherapy treatment planning

To develop a geometric atlas that can predict tumor shrinkage and guide treatment planning for non-small-cell lung cancer. To evaluate the impact of the shrinkage atlas on the ability of tumor dose escalation. The creation of a geometric atlas included twelve patients with lung cancer who underwent both planning CT and weekly CBCT for radiotherapy planning and delivery. The shrinkage pattern from the original pretreatment to the residual posttreatment tumor was modeled using a principal component analysis, and used for predicting the spatial distribution of the residual tumor. A predictive map was generated by unifying predictions from each individual patient in the atlas, followed by correction for the tumor’s surrounding tissue distribution. Sensitivity, specificity, and accuracy of the predictive model for classifying voxels inside the original gross tumor volume were evaluated. In addition, a retrospective study of predictive treatment planning (PTP) escalated dose to the predicted residual tumor while maintaining the same level of predicted complication rates for a clinical plan delivering uniform dose to the entire tumor. The effect of uncertainty on the predictive model’s ability to escalate dose was also evaluated. The sensitivity, specificity and accuracy of the predictive model were 0.73, 0.76, and 0.74, respectively. The area under the receiver operating characteristic curve for voxel classification was 0.87. The Dice coefficient and mean surface distance between the predicted and actual residual tumor averaged 0.75, and 1.6 mm, respectively. The PTP approach allowed elevation of PTV D95 and mean dose to the actual residual tumor by 6.5 Gy and 10.4 Gy, respectively, relative to the clinical uniform dose approach. A geometric atlas can provide useful information on the distribution of resistant tumors and effectively guide dose escalation to the tumor without compromising the organs at risk complications. The atlas can be further refined by using more patient data sets.
Facultative use of thelytokous parthenogenesis for queen production in the polyandrous ant Cataglyphis cursor

The evolutionary paradox of sex remains one of the major debates in evolutionary biology. The study of species capable of both sexual and asexual reproduction can elucidate factors important in the evolution of sex. One such species is the ant Cataglyphis cursor, where the queen maximizes the transmission of her genes by producing new queens (gynes) asexually while simultaneously maintaining a genetically diverse workforce via the sexual production of workers. We show that the queen can also produce gynes sexually and may do so to offset the costs of asexual reproduction. We genotyped 235 gynes from 18 colonies and found that half were sexually produced. A few colonies contained both sexually and asexually produced gynes. Although workers in this species can also use thelytoky, we found no evidence of worker production of gynes based on genotypes of 471 workers from the six colonies producing sexual gynes. Gynes are thus mainly, and potentially exclusively, produced by the queen. Simulations of gynes inbreeding level following one to ten generations of automictic thelytoky suggest that the queen switches between or combines thelytoky and sex, which may reduce the costs of inbreeding. This is supported by the relatively small size of inbred gynes in one colony, although we found no relationship between the level of inbreeding and immune parameters. Such facultative use of sex and thelytoky by individual queens contrasts with other known forms of parthenogenesis in ants, which are typically characterized by distinct lineages specializing in one strategy or the other.
A multi‐micronutrient beverage enhances the vitamin A and zinc status of Nigerian primary school children

We completed a double‐blind, placebo‐controlled trial to determine the effects of a multi‐micronutrient (MMN) beverage on biochemical and anthropometric indicators of nutritional status among a group of primary school children participating in pilot school‐feeding program in Nasarawa State, Nigeria. Anthropometric and biochemical data were obtained from 566 children 5 – 13 y, in two government run primary schools. Children received 250 ml daily servings of a MMN beverage fortified with 26 nutrients, or a placebo beverage, 5‐days per week for 6‐months. All children were given 200 mg Albendazole one week prior to the baseline blood draw, and one month prior to the final blood draw. Height, weight, hemoglobin, C‐reactive protein, ferritin, retinol, and zinc were measured at baseline and at the end of the study. A total of 270 children in the MMN group, and 264 children in the control group completed the study.
Document sentences as a small world

In this paper we describe the possibility of constructing the well-known small world topology for an ordinary document, based on the actual document structure. Sentences in such a graph are represented by nodes, which are connected if and only if the corresponding sentences are neighbors or share at least one common keyword. This graph is built using a carefully selected one-parameter set of keywords. By varying this parameter - the level of meaningfulness - we transition the document-representing graph from a trivial path graph into a large random graph. During such a conversion, as the parameter is varied over its range, the graph becomes a small world. This in turn opens the possibility of applying many well-established ranking algorithms to the problem of ranking sentences and paragraphs in text documents. These rankings are, in turn, crucial for document understanding, summarization and information extraction. These graphs can also serve as a source of interesting small world graphs for the theory of complex networks.
Purification and Characterization of DNA Ligase III from Bovine Testes

Mammalian cell nuclei contain three biochemically distinct DNA ligases. In the present study we have found high levels of DNA ligase I and DNA ligase III activity in bovine testes and have purified DNA ligase III to near homogeneity. The high level of DNA ligase III suggests a role for this enzyme in meiotic recombination. In assays measuring the fidelity of DNA joining, we detected no significant differences between DNA ligases II and III, whereas DNA ligase I was clearly a more faithful enzyme and was particularly sensitive to 3′ mismatches. Amino acid sequences of peptides derived from DNA ligase III demonstrated that this enzyme, like DNA ligase II, is highly homologous with vaccinia DNA ligase. The absence of unambiguous differences between homologous peptides from DNA ligases II and III (10 pairs of peptides, 136 identical amino acids) indicates that these enzymes are either derived from a common precursor polypeptide or are encoded from the same gene by alternative splicing. Based on similarities in amino acid sequence and biochemical properties, we suggest that DNA ligases II and III, Drosophila DNA ligase II, and the DNA ligases encoded by the pox viruses constitute a distinct family of DNA ligases that perform specific roles in DNA repair and genetic recombination.
User Profiling through Deep Multimodal Fusion

User profiling in social media has gained a lot of attention due to its varied set of applications in advertising, marketing, recruiting, and law enforcement. Among the various techniques for user modeling, there is fairly limited work on how to merge multiple sources or modalities of user data - such as text, images, and relations - to arrive at more accurate user profiles. In this paper, we propose a deep learning approach that extracts and fuses information across different modalities. Our hybrid user profiling framework utilizes a shared representation between modalities to integrate three sources of data at the feature level, and combines the decision of separate networks that operate on each combination of data sources at the decision level. Our experimental results on more than 5K Facebook users demonstrate that our approach outperforms competing approaches for inferring age, gender and personality traits of social media users. We get highly accurate results with AUC values of more than 0.9 for the task of age prediction and 0.95 for the task of gender prediction.