Miracle-dz/UniFAR-FTUs huggingface dataset:
NUCB2 polymorphisms are associated with an increased risk for type 2 diabetes in the Chinese population

Background The nucleobindin 2 (NUCB2) gene encodes the NUCB2 protein, which plays a critical role in glucose metabolism and diabetes. This study explored the correlation between NUCB2 genetic variants and type 2 diabetes mellitus (T2DM). The study further examined the different NUCB2 variants that confer risk to T2DM in Chinese Han populations. Methods This study evaluated the anthropometric and glycemic profiles of 578 T2DM patients and 1,609 healthy controls. Subsequently, we genotyped five single nucleotide polymorphisms (SNPs) (rs10832756, rs1330, rs10766383, rs10832757, and rs11024251) in all the study participants using a Sequenom Mass ARRAY SNP genotyping platform. Results The distribution of polymorphisms was significantly different between the T2DM patients and healthy controls. Our logistic regression analysis results showed that the five NUCB2 SNPs are significantly correlated with the risk for T2DM, especially rs11024251(P=2.97×10−6). Interestingly, analysis of male and female sub-populations separately showed that only two of the SNPs (rs10832757 and rs11024251) have significant correlation to T2DM in males [P=0.0244, odds ratio (OR) 1.28 and P=0.0062, OR 1.35, respectively). In females however, we identified four significant SNPs (rs1330, rs10766383, rs10832757, and rs11024251; P<0.05, OR 1.31–1.42). Furthermore, we found that rs1330 is associated with body mass index of female subpopulation only (P=0.0174, β =0.0060). Conclusions NUCB2 polymorphisms could have a pivotal role in the presence of T2DM. Sex-specific SNPs of NUCB2 could account for the differences in clinical features of T2DM between male and female subpopulations. Nevertheless, our results should be replicated using larger sample sizes, and experimental investigations are needed to elucidate the molecular mechanisms of the associations observed in this study.
Inhibitory activity of crude bacteriocin produced by lactic acid bacteria isolated from dadih against Listeria monocytogenes

Pato U, Yusuf Y, Fitriani S, Jonnadi NN, Wahyuni MS, Feruni JA, Jaswir I. 2020. Inhibitory activity of crude bacteriocin produced by lactic acid bacteria isolated from dadih against Listeria monocytogenes. Biodiversitas 21: 1295-1302. The use of natural preservatives called bacteriocin derived from lactic acid bacteria (LAB) is one way of preventing food from being contaminated by pathogenic microorganisms such as Listeria monocytogenes (LM). The aims of this study were to evaluate the ability of LAB isolated from dadih to inhibit the growth of LM and to obtain the antimicrobial components that play a role in inhibiting the growth of LM. The antimicrobial activity of the supernatant obtained from 12 strains of dadih LAB was determined using the paper disk diffusion method. The results showed that the supernatant from the 12 LAB strains was able to inhibit the growth of LM with various inhibition zones. However, out of the 12 LABs, only 9 strains were found to have an inhibition zone of more than 3.5 mm. The antimicrobial compounds of 9 strains were tested and it was found that the antimicrobial compounds of strains R-8, R-14 and R-49 were derived from lactic acid. In addition, 6 strains namely R-43, R-32, R-19, R-55, R-45 and R-41 were derived from bacteriocin based on their sensitivity to pH, heat and enzyme treatments. Crude bacteriocin derived from 6 LAB strains inhibited the growth of LM, and the highest antimicrobial activity was obtained in Streptococcus faecalis subsp. liquefaciens R-55 with an average inhibition zone of 13.87 mm. Bacteriocin produced by strain R-55 can be used as natural preservatives for the prevention of food-borne disease caused by LM.
Chernobyl&Apos;S Subclinical Legacy: Prenatal Exposure to Radioactive Fallout and School Outcomes in Sweden

Japanese atomic bomb survivors irradiated 8-25 weeks after ovulation subsequently suffered reduced IQ [Otake and Schull, 1998]. Whether these findings generalize to low doses (less than 10 mGy) has not been established. This paper exploits the natural experiment generated by the Chernobyl nuclear accident in April 1986, which caused a spike in radiation levels in Sweden. In a comprehensive data set of 562,637 Swedes born 1983-1988, we find that the cohort in utero during the Chernobyl accident had worse school outcomes than adjacent birth cohorts, and this deterioration was largest for those exposed approximately 8-25 weeks post conception. Moreover, we find larger damage among students born in regions that received more fallout: students from the eight most affected municipalities were 3.6 percentage points less likely to qualify to high school as a result of the fallout. Our findings suggest that fetal exposure to ionizing radiation damages cognitive ability at radiation levels previously considered safe.
CMAR_A_238166 2167..2175

Han Xiao Yishu Tang Qian Cheng Jing Liu Xin Li 1Department of Hematology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 2Department of Emergency, The Third Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China Purpose: In patients with hematologic malignancies (HM), bloodstream infections (BSI) and invasive fungal disease (IFD) remain important complications causing considerable mortality and morbidity. At present, the morbidity of IFD and the strategies to initiate antifungal treatment in HM patients with BSI remain unclear. Patients and Methods: Patient characteristics, infection-related variables, and therapyrelated features of 1374 HM patients with proven BSI from three hospitals were reviewed to investigate the epidemiology, risk factors and prognosis of IFD. Results: The morbidity of proven and probable IFD in HM patients with BSI was 11.2%, and the mortality of those patients was 40.5%. Existing IFD risk scores were not accurate enough in distinguishing these patients benefiting from antifungal prophylaxis. Multivariate logistic regression identified age >45 years, profound neutropenia, hypoproteinemia, and use of vasopressors as independent variables associated with IFD morbidity in HM patients with BSI. In patients with proven and probable IFD patients, age >45 years, Pitt bacteremia score >3, use of vasopressors, abnormal blood coagulation, and initiation of antifungal therapy within 72 hrs after the onset of fever were independent prognostic factors. The mortality was significantly reduced in patients with high-risk factors of IFD if they initiate antifungal treatment within 72 hrs after the onset of fever compared to the patients not. Conclusion: The morbidity and mortality of IFD increase significantly in HM patients with BSI. Early antifungal therapy may improve prognosis in HM patients with BSI complicated with IFD risk factors.
The development of drunk behaviour during evacuation

The intoxication of the occupants is hardly considered in the fire safety design, due to the lack of data on the subject. Recent research experiments into the influence of alcohol on evacuation have shown evidence that there might be a correlation between the development of drunk behaviour and the surroundings or context in which the occupants are situated. That is why the experiment in this report investigated the development of drunk behaviour in a group of people within a party environment, independently of alcohol, with the use of non-alcoholic beer as a placebo. The participants were put through 3 identical exercises, which were aimed at testing their balance, reaction times, concentration, hand to eye coordination, problem solving skills, cognitive skills and cooperation. In addition to that they performed 2 evacuations that were used to interrupt their ’drunk behaviour’ and test their reaction, decision and overall evacuation times. They were also analysed for signs of drunk behaviour with video and sound recordings. The results showed clear reduction of performance in the tests for concentration, hand to eye coordination, problem solving skills, cognitive skills and cooperation after the consumption of the beer, but little change in the balance tests. Apart from that, some of the participants showed signs of drunk behaviour, such as playfulness and increase in noise after the alcohol was consumed and these were reduced after the environment changed. Based on this it was concluded that even with non-alcoholic beer some of the participants developed drunk behaviour, like that observed in previous experiments with the use of alcohol.
The Moderating Role of Shariah-Compliant in the Relationship Between Free Cash Flow and Profitability in Family Firm

These research aims to explain agency problem effect on free cash flow in the family firm setting. The free cash flow in the family firm will depend on the agency problem existing to mitigate and decreasing agency cost. Shariah-compliant could use to mitigates the agency problem of free cash flow in the family firm by restricting the free cash flow. This research applied a panel regression to a data set composed 55 families controlled-public company during period 2013-2017. We documented that free cash flow has positive influence on profitability, but low free cash flow by the shariah-compliant firms outperform by highly free cash flow firm. This profitability difference is primarily driven by shariah-compliant is an essential factor in mitigating agency problem for free cash flow by promoting free cash flow limitation.
Innovative Potential of Periodontal Ligament CellSheet Engineering in Functional Implant Therapy

Currently, dental implant therapy is considered as one of the most important procedures in dentistry. Especially osseointegrated implants, which were established by Branemark et al. [1], have been used worldwide as a reliable and consistent procedure. However, recent surveys revealed that peri-implantitis was considered as a major and growing problem in implantology [2-4]. They reported that peri-implantitis occurred in 28-56% of subjects after 5-10 years of use. As one of the causes of periimplantitis, it has been suggested that peri-implant soft tissue may have an impaired defense capacity against exogenous irritation due to lack of periodontal supra-crestal ligaments [5]. Dental researchers are now asked to solve this problem. Giannobile [6] has suggested that the presence of a periodontal ligament (PDL) allows for a more dynamic role beyond the ankylosed dental implants. Implants with periodontal ligament may improve the function of ankylosed implants by providing various biological characteristics of periodontium, such as durability against bacterial challenge and acting as a buffer and sensor of biting force.
OTT_A_237356 2193..2202

Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, People’s Republic of China Background: Ras-related GTP-binding protein 43 (RAB43) plays a key part in the progression of many human cancers. However, the role and functional mechanisms of RAB43 in gastric cancer (GC) remain unknown. Purpose: To elucidate the function and mechanism of RAB43 in the progression of GC. Patients and Methods: One hundred patients with histologically confirmed GC were recruited for this study. Tumor samples and GC cell lines were used to detect RAB43 levels. Cell Counting Kit8 (CCK8) and colony formation assays were used to analyze cell proliferation. Cell migration and invasion ability were examined by wound healing and transwell assays. Western blot assays and quantitative real-time PCR (qRT-PCR) were performed to examine related mRNA and protein expression. In vivo experiments were used to examine the effect of RAB43. Results: Patients with RAB43-positive tumors had worse overall survival than patients with RAB43-negative tumors. Downregulation of RAB43 significantly inhibited cell proliferation and cell metastasis. In contrast, RAB43 overexpression promoted proliferation and metastasis in normal gastric epithelial GES-1 cells. In vivo studies confirmed that RAB43 promoted tumor growth. In addition, the knockdown of RAB43 significantly inhibited cell proliferation and metastasis via phosphatidylinositol-3-kinases/protein-serine-threonine kinase (PI3K/AKT) pathway. Conclusion: RAB43 promotes GC cells proliferation and migration in vivo and in vitro and probably served as a novel potential therapeutic biomarker for GC.
MAPPING BUILT-UP AREAS USING TWO BAND RATIO ON LANDSAT IMAGERY OF ACCRA IN GHANA FROM 1980 TO 2017

Lack of historical land cover and urban growth governance structure makes spatial planning within the economic capitals of developing countries difficult. Monitoring urban built-up growth with insitu methods is complicated. In this paper, long-term Landsat archive is utilised to map the built-up areas of Accra, the economic capital of Ghana, in Africa. Simple two band ratio and band combination is coupled with historic Google Earth imagery to monitor built-up dynamics from 1980-2017. A 10-year period was sub-divided into three parts each; early period, mid period and late period – for analysis. Maximum Likelihood classifier was used for the classification within the ENVI environment. The results show 11.90% as the highest and 4.63% as the lowest built-up growth rates between 2001-2005 and 19962000 respectively. Annual loss of non-built-up areas was 1.31%, and 48.57% over the entire study period. Water bodies lost 0.08% annually but 3.1% over the 37-year period. Highest and lowest overall accuracy were 87.18% and 81.31% respectively, with an average kappa coefficient of 0.7618. Gain in the built-up area was 1676.69 km but non-built up areas lost 1576.10 km while water bodies lost 100.60 km. Results will be of interest to spatial planners, policy makers and land administrators.
Therapeutic Options for Breast Cancer

Breast cancer remains a major public health problem, being the second cause of cancer death in women. There is a marked tendency to restrict the extension of surgical gesture, which directly led to the emergence of two different attitudes: radical surgery and conservative surgery, to which, at least in our country there are still some delays. Prospective and retrospective studies have shown that in 20 years, conservative and radical therapy were about the same rate of survival and disease-free interval, at least for breast cancer stage I and II, the only real counterargument against conservative surgery is that it is encumbered by a higher rate of recurrence local constraint can be removed but by postoperative radiotherapy in principle. Finally, the survival rate is the main parameter distance evaluation assessing the effectiveness of treatment in breast cancer, as in all forms of cancer.
Towards Theme Discovery Paradigm in the Internet of Things

In this paper, we present a novel concept for exploring the Internet of Things (IoT). We develop the concept of a Theme as a way of conveying the purpose of an IoT network, through the interactions of smart objects. This approach draws on the affinity between social networks and IoT and we consider the idea of ‘friendship’ between objects. Finally, we present the initial findings from a study involving a collection of instrumented objects and the identification of sequences and patterns in their data towards establishing the overarching theme of that test-bed network.
Title: Theorising physical activity health promotion: Towards an Eliasian framework for the analysis of health and medicine

This article seeks to advance our understanding of the convergence of physical activity and public health through a novel theorization drawing upon, applying and developing figurational sociological principles of Norbert Elias. More specifically, we focus on four core aspects of Elias’ theoretical corpus: interdependencies; forethought (as an aspect of civilizing processes); the interaction of “fact” and emotion in socially determining knowledge; and the hinge. As such, we argue that contemporary interest in physical activity health promotion (PAHP) can be attributed to the amalgamation of: distinctive figurations of interdependency ties; an associated development in the internalization of human self-control; conceptions of ‘truth’ which derive from a combination of scientific evidence, ideological desires, and the gratification brought from the ‘holding’ of such beliefs; and the intersection of social and biological processes on the human body. This paper advances existing figurationally-informed theoretical analyses of health and medicine, in highlighting the essential interconnectivity of Elias’s key ideas. This approach is, in turn, more faithful to Elias’ advocacy of a radically relational sociological perspective. The result is both an original conceptualization of this increasingly significant social phenomenon, and a more explicit elucidation of the distinctive Eliasian framework
On the Downlink Capacity of Cell-Free Massive MIMO with Constrained Fronthaul Capacity

We investigate the downlink of a cell-free massive multiple-in multiple-out system in which all access points (APs) are connected in a linear-topolpgy fronthaul with constrained capacity and send a common message to a single receiver. By modeling the system as an extension of the multiple-access channel with partially cooperating encoders, we derive the channel capacity of the two-AP setting and then extend the results to arbitrary N-AP scenarios. By developing a cooperating mode concept, we investigate the optimal cooperation among the encoders (APs) when we limit the total fronthaul capacity, and the total transmit power is constrained as well. It is demonstrated that achieving capacity requires a water-pouring distribution of the total available fronthaul capacity over the fronthaul links. Our study reveals that a linear growth of total fronthaul capacity results in a logarithmic growth of the beamforming capacity. Moreover, even if the number of APs would be unlimited, only a finite number of them need to be activated. We found an expression for this number.
Drug Resistance of Mycobacterium tuberculosis Complex in a Rural Setting, Angola

We found high prevalence rates of multidrug-resistant tuberculosis among retreatment patients (71.1%) and persons with new cases (8.0%) in Angola. These findings are of concern but should be interpreted with caution. A national drug-resistance survey is urgently needed to determine the actual prevalence of multidrug-resistant tuberculosis in Angola.
Design of a Multi-Layer Interior Ferrite Permanent Magnet Synchronous Machine for Traction Applications

A novel design of interior ferrite permanent magnet synchronous machine with multi-layer configuration is proposed for traction applications. Although the ferrite magnet can be disadvantaged by its low residual flux density and energy product, it is proposed that flux-focusing and multi-layer configurations can be utilized to harness both permanent magnet (PM) torque and reluctance torque to recoup the loss of the PM torque due to its intrinsic property. The machines with up to three-layer magnets are presented and evaluated comprehensively. The results suggest that the two-layer machine provides the best performance among the three configurations. Furthermore, compared against a commercial rare-earth equivalent, the proposed ferrite machine is shown to have nearly the same torque with 32% less electromagnetic losses. The findings underpin interior ferrite permanent magnet synchronous machine as an attractive alternative for traction applications.
EFL LEARNER’S PRONUNCIATION PROBLEMS: A PHONOLOGICAL ANALYSIS

Many research concerning pronunciation problems of Chinese learners majorly take place within the country, yet very few of them conducted in the context where English is the native language of the country. This study aims to explore the problematic features of pronunciation of Chinese student who studied in Australian university. This study employs qualitative approach with a single case study. The data were collected through an interview and two models of speaking; monologue and reading a text. The problematic features, then, were prioritized based on its context and concept of English as International Language (EIL) context proposed by Jennifer Jenkins (2006). The result showed that the participant was aware about her pronunciation issues. Several problematic segmental and suprasegmental features in which emerged during data analysis also supported this finding. The problematic features are consonant cluster, long and short vowels, /r/ and /l/ sounds, schwa addition in monosyllabic words, /æ/, /ɛ/ and /ʌ/, and issues in word stress, prominence, and intonation. Among all these features, the proposed prioritization of teaching is to focus on word stress, consonant cluster, intonation and prominence, /r/ and/l/, and long and short vowels. The findings also showed slightly difference in which in this study, the participant did not encountered difficulties in pronouncing double /l/ sounds.This study concludes with recommendation for teaching and learning these problematic features.
Biometric Indices and Condition factors of Pomadasys jubelini (Cuvier, 1830) from Obuama Creek, Nigeria

Biometric indices of Pomadasys jubelini from Obuama Creek, Rivers state, Nigeria were investigated using length frequency distributions (LFDs), length-weight relationships (LWRs), length-length relationships (LLRs), condition factors (allometric, K A , Fulton’s, K F and relative, K R ). Specimens were captured in a stretch of the creek from March to September 2019. A total of 229 specimens were examined with the total length (TL) and weight (W) ranging from 8.7 to 50.4 cm and 8.7 to 834.5 g respectively. The standard length (SL) ranged from 5.3 to 46.8 cm, fork length (FL) was between 6.5 to 48.7 cm and the girth length (GL) varied from 4.7 to 38.7 cm. The relationships of weight-length showed a negative allometric growth pattern with a value of "b" of 2,666. Fulton's condition factor (K F ) ranged from 0.10 to 5.45, with an average of 1.21±0.66 indicating perfect wellbeing for the species. The LLR's allometric coefficient ' b ' between TL vs. FL and TL vs. GL showed positive allometric growth, while SL vs. FL, SL vs. TL, SL vs. GL, and GL vs. TL showed negative allometric growth, although the values were close to 1. These findings also provided some new and updated information on some of the morphometric characters of Pomadasys jubelini in Obuama Creek that could be useful for fisheries management and fish species protection measures in the creek and adjacent habitats.
USE OF CROCODILIAN NIGHT COUNT DATA FOR POPULATION TREND ESTIMATION1

Night counts represent an index of the total population (Davis and Winstead 1980, Bayliss 1987). Although the exact relationship between a count and the total population (sighting proportion) may be unknown, for trend analysis, we either assume that this relationship remains constant over time or that we can account for factors affecting the sighting proportion. Thus, any change in counts should reflect a proportionate change in the total population.