Miracle-dz/UniFAR-FTUs huggingface dataset:
A measured look

here’s enough lead time between submission deadlines and publication to make the findings of the Columbia Accident Investigation Board old news by the time you read this. However, as I write, it is very fresh. Publishing the report [1] marks the culmination of work that went uninterrupted since the loss of Columbia on 1 February 2003 and included debris recovery, testing, analysis, reviews, and interviews. The many findings publicized throughout the investigation meant there were not too many surprises. The report ties things together, describing a culture with serious shortcomings, and makes a series of recommendations for return to flight. On the 26 August, I joined my colleagues at Stennis Space Center to hear Sean O’Keefe’s briefing to NASA. During his address, he made a connection between the loss of Columbia and the Apollo 1 fire in 1967 that killed Astronauts Grissom, White, and Chaffee [2]. Eugene Krantz, then flight director, is credited with a speech in the aftermath of the fire in which he distilled to two the attributes people needed to have for NASA to be—and stay—successful and not lose Astronauts: Tough and Competent. I mulled over this mantra on the way back to Bldg 8306.
Multigenerational Regulation of the Caenorhabditis elegans Chromatin Landscape by Germline Small RNAs.

In animals, small noncoding RNAs that are expressed in the germline and transmitted to progeny control gene expression to promote fertility. Germline-expressed small RNAs, including endogenous small interfering RNAs (endo-siRNAs) and Piwi-interacting RNAs (piRNAs), drive the repression of deleterious transcripts such as transposons, repetitive elements, and pseudogenes. Recent studies have highlighted an important role for small RNAs in transgenerational epigenetic inheritance via regulation of heritable chromatin marks; therefore, small RNAs are thought to convey an epigenetic memory of genomic self and nonself elements. Small RNA pathways are highly conserved in metazoans and have been best described for the model organism Caenorhabditis elegans. In this review, we describe the biogenesis, regulation, and function of C. elegans endo-siRNAs and piRNAs, along with recent insights into how these distinct pathways are integrated to collectively regulate germline gene expression, transgenerational epigenetic inheritance, and ultimately, animal fertility. Expected final online publication date for the Annual Review of Genetics Volume 53 is November 25, 2019. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Regulatory Mechanisms of Soft Palate Development and Malformations

Orofacial clefting is the most common congenital craniofacial malformation, appearing in approximately 1 in 700 live births. Orofacial clefting includes several distinct anatomic malformations affecting the upper lip and hard and soft palate. The etiology of orofacial clefting is multifactorial, including genetic or environmental factors or their combination. A large body of work has focused on the molecular etiology of cleft lip and clefts of the hard palate, but study of the underlying etiology of soft palate clefts is an emerging field. Recent advances in the understanding of soft palate development suggest that it may be regulated by distinct pathways from those implicated in hard palate development. Soft palate clefting leads to muscle misorientation and oropharyngeal deficiency and adversely affects speech, swallowing, breathing, and hearing. Hence, there is an important need to investigate the regulatory mechanisms of soft palate development. Significantly, the anatomy, function, and development of soft palatal muscles are similar in humans and mice, rendering the mouse an excellent model for investigating molecular and cellular mechanisms of soft palate clefts. Cranial neural crest–derived cells provide important regulatory cues to guide myogenic progenitors to differentiate into muscles in the soft palate. Signals from the palatal epithelium also play key roles via tissue-tissue interactions mediated by Tgf-β, Wnt, Fgf, and Hh signaling molecules. Additionally, mutations in transcription factors, such as Dlx5, Tbx1, and Tbx22, have been associated with soft palate clefting in humans and mice, suggesting that they play important regulatory roles during soft palate development. Finally, we highlight the importance of distinguishing specific types of soft palate defects in patients and developing relevant animal models for each of these types to improve our understanding of the regulatory mechanism of soft palate development. This knowledge will provide a foundation for improving treatment for patients in the future.
Targeting Angiogenesis in Prostate Cancer

Prostate cancer is the most commonly diagnosed cancer among men in the Western world. Although localized disease can be effectively treated with established surgical and radiopharmaceutical treatments options, the prognosis of castration-resistant advanced prostate cancer is still disappointing. The objective of this study was to review the role of angiogenesis in prostate cancer and to investigate the effectiveness of anti-angiogenic therapies. A literature search of clinical trials testing the efficacy of anti-angiogenic therapy in prostate cancer was performed using Pubmed. Surrogate markers of angiogenic activity (microvessel density and vascular endothelial growth factor A (VEGF-A) expression) were found to be associated with tumor grade, metastasis, and prognosis. Six randomizedstudies were included in this review: two phase II trials on localized and hormone-sensitive disease (n = 60 and 99 patients) and four phase III trials on castration-resistant refractory disease (n = 873 to 1224 patients). Although the phase II trials showed improved relapse-free survival and stabilisation of the disease, the phase III trials found increased toxicity and no significant improvement in overall survival. Although angiogenesis appears to have an important role in prostate cancer, the results of anti-angiogenic therapy in castration-resistant refractory disease have hitherto been disappointing. There are various possible explanations for this lack of efficacy in castration-resistant refractory disease: redundancy of angiogenic pathways, molecular heterogeneity of the disease, loss of tumor suppressor protein phosphatase and tensin homolog (PTEN) expression as well as various VEGF-A splicing isoforms with pro- and anti-angiogenic activity. A better understanding of the molecular mechanisms of angiogenesis may help to develop effective anti-angiogenic therapy in prostate cancer.
Public speaking anxiety decreases within repeated virtual reality training sessions

Therapy for public speaking phobia using virtual reality exposure (VRE) has focused on distress arousal rather than distress habituation. Understanding habituation will help optimise session duration, making treatment more affordable and accessible. This pilot study utilised within-speech repeated measures to examine distress habituation during three brief public speaking scenarios in a non-clinical sample (n = 19; 18–76 years). VRE elicited significant distress in all three scenarios. Although within-scenario distress habituation was not observed, between-scenario habituation was partially supported. An increase in distress during the second scenario indicated that three consecutive speech performances were critical in achieving habituation. Brief repeated VRE scenarios using an agent audience were effective in eliciting public speaking distress, as well as habituation.
Ovarian responses to intramuscular or intravenous administration of prostaglandin F2 alpha in control and FSH-treated beef heifers.

Sixty Simmental crossbred heifers 18 to 20 mo of age were detected in estrus and assigned at random to a 2 x 2 factorial design study with 30 controls, and 30 given FSH. Half of each group was given prostaglandin F2 alpha (PGF) i.v. and the rest i.m. Injections of follicle-stimulating hormone were started on d 7 to 14 of an estrous cycle and continued for 5 d or until ovariectomy; PGF was administered either i.v. or i.m. at 48 (25 mg) and 60 (15 mg) h after the initial FSH injection. Control females received a similar PGF treatment on a day between d 9 and 15 of the estrous cycle. Blood samples were collected from all animals immediately before PGF administration and every 12 h thereafter until ovariectomy. Within each of the four experimental subgroups, ovariectomies were performed at either 24, 48 or 72 h (five/time group) after initial PGF injection. Ovarian and corpus luteum (CL) weights were recorded as well as number and size of follicles and number of ovulations. Regression of the CL was slower (P less than .05) after administration of PGF i.v. than i.m. (CL weight was 2.6 vs 3.3 +/- .2 g for i.m. and i.v. groups, respectively). Exogenous FSH increased estradiol-17 beta (E2) concentrations, and FSH-treated heifers had more (P less than .05) early ovulations than control heifers did. Ovulations in FSH-treated heifers had begun to occur by 24 h after i.v. and i.m. PGF injection. (ABSTRACT TRUNCATED AT 250 WORDS)
Sandblasted and Acid Etched Titanium Dental Implant Surfaces Systematic Review and Confocal Microscopy Evaluation

The field of dental implantology has made progress in recent years, allowing safer and predictable oral rehabilitations. Surely the rehabilitation times have also been reduced, thanks to the advent of the new implant surfaces, which favour the osseointegration phases and allow the clinician to rehabilitate their patients earlier. To carry out this study, a search was conducted in the Pubmed, Embase and Elsevier databases; the articles initially obtained according to the keywords used numbered 283, and then subsequently reduced to 10 once the inclusion and exclusion criteria were applied. The review that has been carried out on this type of surface allows us to fully understand the features and above all to evaluate all the advantages or not related. The study materials also are supported by a manufacturing company, which provided all the indications regarding surface treatment and confocal microscopy scans. In conclusion, we can say that, thanks to these new surfaces, it has been possible to shorten the time necessary to obtain osseointegration and, therefore, secondary stability on the part of implants. The surfaces, therefore, guarantee an improved cellular adhesion and thanks to the excellent wettability all the biological processes that derive from it, such as increases in the exposed implant surface, resulting in an increase in bone-implant contact (BIC).
Cathepsin-Dependent Apoptosis Triggered by Supraoptimal Activation of T Lymphocytes: A Possible Mechanism of High Dose Tolerance1

High doses of Ag can paradoxically suppress immune responses in vivo. This Ag-specific unresponsiveness (termed high dose tolerance) involves extrathymic mechanisms in mature T lymphocytes. To investigate these mechanisms, we used the in vitro model of PBL activated with anti-CD3 or PHA. In these conditions, increasing mitogen concentrations resulted in a reduction of the proliferative response, associated with an increased percentage of apoptotic cells. Apoptosis did not require prior exposure to IL-2, it was not the consequence of CD178/CD95 or TNF/TNFR interactions, and was therefore clearly distinct from activation-induced cell death. Although the pan-caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (zVAD-fmk) decreased DNA fragmentation, cytochrome c release and caspase-9 and caspase-3 activation were not implicated, suggesting that this apoptosis did not primarily involve the intrinsic mitochondrial pathway. E64d, a cysteine protease inhibitor, as well as specific inhibitors of cathepsin B and cathepsin L conferred protection. We further demonstrated that cathepsin B and cathepsin L were released from the lysosomes and catalytically active in the cytosol. Release of cathepsin B and cathepsin L was the consequence of lysosomal membrane permeabilization without complete disruption of the cytosol-lysosome pH gradient. These results demonstrate a role for cathepsins in supraoptimal activation-induced apoptosis in vitro and suggest their possible participation in high dose tolerance in vivo.
Estimation of Implicit user Influence from Proxy Logs - An Empirical Study on the Effects of Time Difference and Popularity

In this paper, we propose a framework for estimating implicit user influence from proxy logs. For the estimation, we employ a vector representation of user interactions obtained from log data by taking account of popularity of web pages and difference of access time to them. One of the key issues for successful estimation is how to model the popularity and time difference. Since appropriate models depend on application domains, we propose various models of them. We confirm the effectiveness of the proposed framework by conducting experiments on web page recommendation and community discovery for real proxy logs.
CADRE CONCEPTUEL POUR UN SYSTEME DE TRACABILITE EN CONCEPTION COLLABORATIVE

En conception collaborative, les resultats de chaque activite entrainent des modifications sur les differents elements de fla situation de travail et sont susceptibles de perturber l'achevement des autres activites. L'utilisation d'outils collaboratifs favorise le processus de capitalisation surtout lors de la collecte d'informations. De meme, la capitalisation des connaissances peut aussi favoriser la cooperation des concepteurs dans leurs activites communes. Ce papier presente un nouveau cadre conceptuel pour un systeme de tracabilite, base essentiellement sur le concept de situation, dans le dessein d'ameliorer le partage des connaissances et la conception collaborative. Son but est de fournir aux concepteurs un outil collaboratif pour la capture d'informations sur leur activite et leur travail en vue d'ameliorer leur pratique.
Edge computing in IoT context: Horizontal and vertical Linux container migration

In recent years, the development of the Internet of Things (IoT) has largely been supported by the parallel development of the Cloud computing capacities. Cloud computing offered elastic and on-demand computing power able to host and support crucial IoT functions. However, the proliferation of connected objects poses the problem of the confidentiality of the data produced. This proliferation also threatens the performances of the supporting networks. To tackle those problems, the research community has recently turned to Fog Computing. In this paper, we present CIoud4IoT, a platform able to perform horizontal (roaming) and vertical (offloading) migration of IoT functions. We implement our demonstration using a Kubernetes cIuster organised in three tiers: Cloud, Edge and IoT gateways. Our first use cases shows how IoT function roaming can be used in the context of health care data exploitation. The second use case exploits the IoT offloading capacity of our platform to optimize the remote diagnostic of mechanical engines.
A comprehensive study for dielectric charging process in silicon nitride films for RF MEMS switches using Kelvin Probe Microscopy

In this work we present for the first time a systematic investigation for the dielectric charging in silicon nitride films for RF MEMS capacitive switches based on Kelvin Probe Microscopy methodology. The effect of the underneath physical layer over which the dielectric will be deposited has been first investigated through depositing SiN films over thermally grown oxide, evaporated gold and electroplated gold layers. Then, the dielectric films have been deposited with different thicknesses in order to study the impact of dielectric thickness. Finally, the effect of the deposition conditions has been investigated through depositing SiN films using low and high frequency PECVD method.
THE ANN APPROXIMATION OF THE CH4 COMBUSTION MODEL: THE HEAT RELEASE

The calculation of the heat release from the combustion process of the CH4 is presented of the paper. Correct calculation results of the heat released from combustion is important for design, modelling and testing phenomena in combustion chambers of internal combustion engines. The paper presents results of calculations for the kinetic mechanism of methane combustion GriMech 3 for different thermodynamic parameters and composition of the combusted mixture. The calculations were performed for all possible configurations of the variable temperature range from 1100K to 3600K, the variable pressure in the range of 2MPa to 5MPa, variable humidity of charged air from 10 to 30 grams of water per 1 kg of air and variable mole fractions of charge air. Results of the kinetic calculation of combustion process are qualitatively consistent with the data available in literature. The next stage of research was approximation of obtained results with the trained artificial neural network. Input data needed to approximate the energy of the combustion process consisted of 52 mole fractions of chemical species and temperature and pressure process. Approximation results have meant square error not exceeded 0.04% for the test data and 0.02% for the validation data. The maximum error for a single result was 1.9% compared to data obtained with chemical kinetic calculations.
Visual Improvement for Dense Foggy & Hazy Weather Images, Using Multimodal Enhancement Techniques

Image enhancement processes consist of a collection of techniques that inquire about to improve the visual appearance of degraded image. This paper introduces a multimodal enhancement technique for dense foggy images. The present available techniques don't work in low visibility like dense fog. The proposed methods changes the intensity component among the converted HIS components from the RGB components of the original foggy image. Again by converting back to RGB components, the foggy image tends to appear more clearly than the original image in terms of Peak Signal to Noise Ratio (PSNR) and Mean Square Error (MSE). [2] Finally the enhanced foggy image is obtained and the results are presented [9].
KINESIOTAPING FOR BREAST CANCER RELATED LYMPHEDEMA

Lymphedema is a disability resulting in some patients that undergo the surgi- cal procedure mastectomy, with a difficult treatment. In recent years, kinesio- taping has been used particularly in sport injuries, and its pain management is an alternative treatment modality. However, its effect mechanisms are not exactly known. Additional to the pain management, kinesiotaping effectively decreases disability in the treatment of lymphedema by creating alternative drainage pathways. We report three cases, which have used kinesiotaping for the treatment of left upper extremity lymphedema after mastectomy.
ABCB1 and Cytochrome P450 Polymorphisms: Clinical Pharmacogenetics of Clozapine

To examine the genetic factors influencing clozapine kinetics in vivo, 75 patients treated with clozapine were genotyped for CYPs and ABCB1 polymorphisms and phenotyped for CYP1A2 and CYP3A activity. CYP1A2 activity and dose-corrected trough steady-state plasma concentrations of clozapine correlated significantly (r = −0.61; P = 1 × 10−6), with no influence of the CYP1A2*1F genotype (P = 0.38). CYP2C19 poor metabolizers (*2/*2 genotype) had 2.3-fold higher (P = 0.036) clozapine concentrations than the extensive metabolizers (non-*2/*2). In patients comedicated with fluvoxamine, a strong CYP1A2 inhibitor, clozapine and norclozapine concentrations correlate with CYP3A activity (r = 0.44, P = 0.075; r = 0.63, P = 0.007, respectively). Carriers of the ABCB1 3435TT genotype had a 1.6-fold higher clozapine plasma concentrations than noncarriers (P = 0.046). In conclusion, this study has shown for the first time a significant in vivo role of CYP2C19 and the P-gp transporter in the pharmacokinetics of clozapine. CYP1A2 is the main CYP isoform involved in clozapine metabolism, with CYP2C19 contributing moderately, and CYP3A4 contributing only in patients with reduced CYP1A2 activity. In addition, ABCB1, but not CYP2B6, CYP2C9, CYP2D6, CYP3A5, nor CYP3A7 polymorphisms, influence clozapine pharmacokinetics.
An LMS adaptive second-order Volterra filter with a zeroth-order term: steady-state performance analysis in a time-varying environment

This article studies the steady-state performance of the least mean square (LMS) adaptive second-order Volterra filter (SOVF) with a zeroth-order term for Gaussian inputs. The mean-square-error (MSE) criterion is evaluated first. Then, SOV LMS algorithm-based updating equations are derived. Next, the steady-state performance of the recursions is analyzed for a random walk model for the unknown system parameters, and the steady-state excess MSE is evaluated. Finally, the theoretical performance predictions are shown to be in good agreement with simulation results, especially for small step sizes.
Does the localisation of cultural markers affect user's destination image?

This paper represents a pioneer work on the discussion of the effects of the localisation of cultural markers on tourism destination websites on user’s destination image. First, a preliminary research was conducted on 130 sites in order to identify the cultural markers of New Zealand, Chinese and Indian tourism destination sites. Afterwards, an experiment was conducted to investigate the influence of the localisation of cultural markers on destination image. A fictitious tourism destination website was created for the purpose of this research and tailored for the New Zealand audience. In total, 400 students participated, performing tasks on the site and answering a survey. Results indicate that there are clear differences in the cultural markers of New Zealand, Chinese and Indian destination sites and that incongruent cultural markers lead to a more positive affective and overall image of the place.
University of Groningen Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease

Collagen is a macromolecule that has versatile roles in physiology, ranging from structural support to mediating cell signaling. Formation of mature collagen fibrils out of procollagen a-chains requires a variety of enzymes and chaperones in a complex process spanning both intracellular and extracellular post-translational modifications. These processes include modifications of amino acids, folding of procollagen a-chains into a triple-helical configuration and subsequent stabilization, facilitation of transportation out of the cell, cleavage of propeptides, aggregation, cross-link formation, and finally the formation of mature fibrils. Disruption of any of the proteins involved in these biosynthesis steps potentially result in a variety of connective tissue diseases because of a destabilized extracellular matrix. In this review, we give a revised overview of the enzymes and chaperones currently known to be relevant to the conversion of lysine and proline into hydroxyproline and hydroxylysine, respectively, and the O-glycosylation of hydroxylysine and give insights into the consequences when these steps are disrupted. ARTICLE HISTORY Received 1 August 2016 Revised 18 November 2016 Accepted 5 December 2016
UC-EBG on reflector for 3.4S-GHz frequency band antenna array application

A compact MIMO antenna using a UC-EBG structure as reflector applied in IMT -advanced is proposed. It consists of 3 × 2 CPW-fed CPS dipoles. We conducted the antenna array in terms of active impedance, and test many parameters of the antenna. Unlike the conventional reflector, the distance between the radiating patch and reflector is 1 cm, which is much shorter than λ / 4. It can decrease the bulk of the antenna array, and the mutual coupling between adjacent elements also decreased. In addition, the gain and directivity of the antenna array was increased.