Miracle-dz/UniFAR-FTUs huggingface dataset:
Application of cut set method to reliability evaluation of mine ventilation networks

Providing a fresh and cool airflow in underground mines is one of the main concerns during mining. Destruction of support systems, the presence of undesirable objects in the airway and distortion of airflow are the parameters involved that would result in pressure loss, which would affect the ventilation network. There are a lot of research works about the ventilation network planning that consider the confidence in the planning but how reliable are these designs? These questions can be answered using the quantitative reliability evaluation. For the reliability evaluation of mine ventilation network, tunnel resistance and flow rate changes for all branches are considered as the reliability indices and criteria. This paper describes a stepwise method for evaluation of the underground coal mine network reliability associated with major losses using the cut set method. The reliability of the entire network is achieved by the reliability of every single component. The proposed model is implemented by the Takht coal mine. The Takht mine ventilation network probability of failure is in the range of 19-100% so reliability is in the range of 0-81% for the entire ventilation network.
Study on anticancer activity and correlation with meridian tropism of toxic Chinese materia medica

肿瘤已成为威胁人类健康和导致死亡的主要原 因之一,数据表明过去 10 年间,全球癌症发病率增 长了 22%,并呈逐年上升的趋势。 其中肺癌、胃癌、 食道癌、肝癌、直肠癌等恶性肿瘤均居癌症新发病 率和死亡率的前 10 位。 以毒攻毒法是中医治疗恶 性肿瘤的重要手段之一,有毒中药在配合手术及放 化疗诊治恶性肿瘤及其并发症的过程中,只要合理 控制使用剂量,在保留药效成分的同时注重配伍减 毒,就会发挥意想不到的良效。 归经理论是中药药性理论的重要组成部分,它 把药物作用与人体脏腑经络密切联系,来说明药物 对机体某部分的选择性作用,为临床用药提供依据。 徐树楠通过同位素示踪技术,对标记的 23 种中药 成分在人体脏腑分布与归经关系进行了研究,发现 药物成分的分布与其归经所属脏腑基本一致或大致 相符的占 87%,提示在归经理论的指导下,可以有 针对性地选择中药特别是含有有毒成分的中药对机 体特定脏腑的癌变进行治疗,对于改善患者症状与 体征,减轻放化疗不良反应、延长患者生存期等方 面具有一定的指导意义。 本文以《中国药典》2010 年版收录、中医临床 常用方药以及上市中成药中的有毒中药为研究对 象,系统地总结了其性味归经、化学成分、药理作 用,并从其抗肿瘤及其并发症的研究与应用角度探 讨其与归经的关系,为该类中药在抗肿瘤天然药物 研究与应用方面提供依据与参考。 1 有毒中药信息统计 1.1 药材来源统计 有毒中药的信息均来自其在《中国药典》2010 年版一部“性味与归经”项下的内容。 检索得到 有毒中药材和饮片共计 84 个品种,通过对药材的采 集、炮制以及归经进行合并整理得到植物药 71 个,
Porting AODV-UU into NS-Miracle

The NS-Miracle[1] (Multi InteRfAce Cross Layer Extension for NS) framework lacks support for AODV (Ad-hoc On-demand Distance Vector) routing. Research projects at Karlstad University need this feature for simulation of wireless Ad-hoc networks. The Network Simulator (NS-2)[2] has support for AODV routing, but NS-2 does not meet the requirements in simulation with multihomed nodes. AODVUU[3] is a draft compliant Linux implementation of the AODV protocol from Uppsala University. This implementation also includes a port for NS-2. This project has resulted in a port of AODV-UU for NS-2 into NSMiracle compatible modules. We have also extended the original code to support multiple interfaces. Different simulation scenarios have been created and analyzed to verify functionality of the port. However, simulation tests that cover more technologies and topologies are still needed. Features such as automatic interface discovery and AP-gateway mode are proposals for future work.
Demo: Optimizing Smartphone Power Consumption through Dynamic Resolution Scaling

The extremely-high display density of modern smartphones imposes a significant burden on power consumption, yet does not always provide an improved user experience and may even lead to a compromised user experience. As human visually-perceivable ability highly depends on the user-screen distance, a reduced display resolution may still achieve the same user experience when the user-screen distance is large. This provides new power-saving opportunities. We present a flexible dynamic resolution scaling system for smartphones. The system adopts an ultrasonic-based approach to detect the user-screen distance at low-power cost and makes scaling decisions automatically for maximum user experience and power saving. App developers or users can also adjust the resolution manually and dynamically as their needs. Our system is able to work on the existing commercial smartphones and support the legacy apps, without requiring re-building the ROM or any changes from apps.
Prescribed fire in a Great Basin sagebrush ecosystem: Dynamics of soil extractable nitrogen and phosphorus

Pinyon and juniper have been expanding into sagebrush (Artemisia tridentata) ecosystems since settlement of the Great Basin around 1860. Herbaceous understory vegetation is eliminated as stand densities increase and the potential for catastrophic fires increases. Prescribed fire is increasingly used to remove trees and promote recovery of sagebrush ecosystems. We quantified the effects of prescribed fire, vegetation type, and time following fire on soil KCl extractable nitrogen and NaHCO3 extractable phosphorus in a pinyon–juniper woodland and its associated sagebrush ecosystem immediately before and for 4 years after a spring prescribed burn. Potassium chloride extractable NH4 + and total inorganic-N increased immediately following prescribed fire, and extractable NO3 decreased immediately after the burn. In the surface layer (top 8 cm), extractable NH4 + remained elevated compared to the control through year 2 after the burn. By the first fall postburn extractable NO3 and total extractable inorganic-N increased and remained elevated over the control through year 3 after the burn in the surface layer. For the entire soil profile (52 cm), the burn had no effect on NH4 , and the effects on total extractable inorganic-N were no longer significant after year 1. However, NO3 remained elevated over the control through year 2 post-fire for the soil profile. Near surface NaHCO3 extractable ortho-P increased immediately following fire, and remained elevated through year 2 post-fire. No fire effects were observed for extractable ortho-P in deeper horizons. Our data show that plant available nitrogen can remain elevated for extended see front matter r 2007 Elsevier Ltd. All rights reserved. jaridenv.2007. 05.006 nding author. Tel. : +1 775 784 1887; fax: +1 775 784 4583. dresses: brau@unr.nevada. edu (B.M. Rau), blank@unr.nevada. edu (R.R. Blank), s.fed. us (J.C. Chambers), dwj@unr.edu (D.W. Johnson).
A Strong Authentication Protocol Based on Portable One-Time Dynamic URLs

This work proposes a new strong authentication protocol for the prevention of identity and private personal data theft suffered by users in the Internet. Identity theft is a problem of rising impact amongst Internet users and service providers and it occurs, very frequently, through techniques like phishing. The main reason for the high rates of success is user unexperience and their inability to pay attention to the details that allow them to tell a legitimate site from its fake version. In this paper we present a new strong 3–phaseauthentication protocol which makes use of Portable One–TimeDynamic URLs for the prevention of identity theft over the Internet. Moreover, a prototype of such a scheme has been implemented to measure the usability and scalability of the proposal.
ANTI-PROLIFERATIVE ACTIVITY OF AQUEOUS AND ETHANOLIC EXTRACTS OF BRYOPHYLLUM

Plants derived naturalproducts are the source of most active components of medications, which in turn play a significant role in the treatment or prevention of human illnesses. Tropical plants have been investigated intensively during the last decades in order to evaluate the possibility of developing new, sustainable, natural and affordable drugs that can piay a significant role in the treatment or prevention of human illnesses. Bryophyllum pinnatum (Lam.) Oken, is an erect, succulent, perennial shrub that has been reported to have a lot of medicinal properties including antimicrobial, antioxidant and anti-tumor. The aim of this study was to determine the anti¬ proliferative potential of the aqueous and ethanolic extracts of Bryophyllum pinnatum using the Saccharomyces cerevisiae (budding yeast) model. The concentration range tested (0, 2, 4, 6, 8, lOmg/ml), for the aqueous extract of Bryophyllum pinnatum exhibited strong anti-proliferative activity with a percentage inhibition of 73.12% at lOmg/mlfollowing 24 hours of incubation. This value was compared to value obtainedfrom the percentage inhibition ofSaccharomyces cerevisiae by the controldrug, Methotrexateat 125pg/ml(86.7%). Thefindingssuggest that aqueousextractof Bryophyllum pinnatum has high anti-proliferative potential and maybe a good source for the productionofdrugs with stronganti-proliferativepotential.
Free Space Optics : A Viable Last-Mile Solution

The telecommunications deregulation of 1996 has paved the way for a massive expansion in global telecommunication networks over the past few years (Ref. 1). Starting with the growth of long-haul WANs (wide area networks), followed by a recent interest in MANs (metropolitan area networks), there has been a tremendous explosion in bandwidth demand and requirements. For the end user to access and utilize the broad array of services made available through these developments, network designers must provide a flexible and cost-effective solution for the "last mile" between the LANs (local area networks), MANs, or WANs. This paper explores FSO (free space optics) as an access technology in the last mile of MANs. Merrill Lynch predicts FSO will grow into a $2 billion market by 2005 (Ref. 4). According to the report, "the drivers for this market are a mere 5 to 6 percent penetration of fiber to business buildings; cost effective solution versus RF (radio frequency) or fiber; and significant capacity which can only be matched by a physical fiber link. " This paper describes FSO technology, its capabilities and limitations. The paper addresses the case for FSO within the last-mile broadband wireless arena and outlines core applications and deployment architectures to suit the needs of a specific business type. The paper also provides an insight into the Bechtel FSO initiative, with performance results.
Pengaruh Iradiasi Gamma pada Konversi Biomassa Lignoselulosa Sabut Kelapa Menjadi Bioetanol

Sabut kelapa adalah salah satu limbah lignoselulosa yang dapat dikonversikan menjadi bioetanol. Konversi bioetanol pada penelitian ini dilakukan melalui beberapa tahapan yaitu proses pre-treatment, proses Saccharification and Simultaneous Fermentation (SSF), dan proses pemurnian. Proses pre-treatment sebagai proses pemecahan ikatan lignoselulosa menjadi poin utama dalam proses konversi biomassa lignoselulosa. Penelitian ini dilakukan untuk mengetahui pengaruh iradiasi gamma terhadap pemecahan ikatan lignoselulosa pada proses pre-treatment tersebut. Proses iradiasi gamma divariasikan pada dosis sebesar 0 kGy, 100 kGy, 150 kGy, 200 kGy, 250 kGy dan dilanjutkan pre-treatment secara kimia menggunakan NaOH 4%. Kemudian dilanjutkan proses pemurnian setelah proses SSF selama 72 jam. Kadar bioetanol yang diperoleh setelah proses pemurnian diukur menggunakan metode refraktometri dan piknometri. Pada penelitian ini diperoleh kadar bioetanol tertinggi pada dosis iradiasi gamma 200 kGy, yaitu 35,15% untuk metode refraktometri, dan 36,77% untuk metode piknometri. Hasil tersebut jauh lebih tinggi bila dibandingkan dengan kadar bioetanol tanpa iradiasi gamma yaitu 2,45% untuk metode refraktometri, dan 6,92% untuk metode piknometri. Penelitian ini menunjukkan bahwa metode pre-treatment dengan iradiasi gamma dapat menghasilkan kadar bioetanol yang lebih tinggi dibandingkan tanpa menggunakan iradiasi gamma.Coconut husk is one of lignocellulosic wastes that can be converted into bioethanol. Bioethanol conversion in this study was carried out through several stages, namely the pre-treatment process, the Saccharification and Simultaneous Fermentation (SSF) process, and the purification process. The pre-treatment process as the process of breaking lignocellulosic bonds becomes the main point in the process of lignocellulosic biomass conversion. This research was conducted to determine the effect of gamma irradiation to breaking lignocellulosic bonds on the pre-treatment process. Gamma irradiation process was varied in doses of 0 kGy, 100 kGy, 150 kGy, 200 kGy, 250 kGy and continued with chemical pre-treatment using 4% NaOH. Then the purification process was continued after the SSF process for 6 days. Bioethanol levels obtained after the purification process were measured using refractometry and picnometry methods. In this study, the highest levels of bioethanol were obtained at a gamma irradiation dose of 200 kGy, namely 34.93% for the refractometry method, and 26.67% for the picnometry method, respectively. These results are much higher when compared to bioethanol levels without gamma irradiation, which is 2.25% for the refractometry method, and 5.49% for the picnometry method, respectively. This study shows that the pre-treatment method with gamma irradiation can produce higher levels of bioethanol than without using gamma irradiation.
Investigating the drivers of sustainability oriented innovation: the role of Corporate Social Responsibility

This contribution explores the role of Corporate Social Responsibility (CSR) on the adoption on Sustainability Oriented Innovation. In accordance with previous research that show the effect of CSR depends on which CSR practices are taking into account, we consider different measures of CSR practices To analyse this relationship we adopt an empirical approach based on a survey carried on in Luxembourg in 2008 on firm CSR practices jointly with the Community Innovation Survey carried on in 2012. With a sample of 286 firms and a Heckman procedure, the study underlines the importance to differentiate the type of CSR strategy (strategic vs responsive). Our results show that strategic CSR explain the adoption of Sustainability Oriented Innovation.
PaccMann: Designing anticancer drugs from transcriptomic data via reinforcement learning

With the advent of deep generative models in computational chemistry, in silico anticancer drug design has undergone an unprecedented transformation. While state-of-the-art deep learning approaches have shown potential in generating compounds with desired chemical properties, they disregard the genetic profile and properties of the target disease. Here, we introduce the first generative model capable of tailoring anticancer compounds for a specific biomolecular profile. Using a RL framework, the transcriptomic profiles of cancer cells are used as a context for the generation of candidate molecules. Our molecule generator combines two separately pretrained variational autoencoders (VAEs) – the first VAE encodes transcriptomic profiles into a smooth, latent space which in turn is used to condition a second VAE to generate novel molecular structures on the given transcriptomic profile. The generative process is optimized through PaccMann, a previously developed drug sensitivity prediction model, to obtain effective anticancer compounds for the given context (i.e., transcriptomic profile). We demonstrate how the molecule generation can be biased towards compounds with high predicted inhibitory effect against individual cell lines or specific cancer sites. We verify our approach by investigating candidate drugs generated against specific cancer types and find the highest structural similarity to existing compounds with known efficacy against these cancer types. We envision our approach to transform in silico anticancer drug design by leveraging the biomolecular characteristics of the disease in order to increase success rates in lead compound discovery.
Chapter 5 A nascent definiteness marker in Yokot ’ an Maya

This paper examines the characteristics of a nascent definiteness marker in the Yokot’an language from the Mayan family from both a synchronic and diachronic perspective. The paper examines the contemporary distribution of the determiner ni, comparing it to that of the enclitic ba, which roughly corresponds to a topic marker. It employs Centering Theory to analyze oral materials, concluding that the use of the two particles is partially motivated by the processing cost of attentional shifts. Given that the determiner ni has been argued to develop from the distal demonstrative jini through grammaticalization, a diachronic perspective is also considered. The different synchronic uses of the determiner illustrated in this paper are then compared to the grammaticalization stages proposed for the development of definite articles. Both approaches ultimately suggest that ni conveys definiteness based on discourse-salience, not identifiability. The diachronic analysis further suggests that ni has started to bear some contrastive meaning related to reference in restricted contexts (reference to kinds in generic statements and specific reference in negative existential statements), indicating that the use of ni has spread beyond a pure topicality marker. Furthermore, the synchronic textual analysis in terms of Centering Theory clarifies some of the claims in Grammaticalization Theory regarding the early stages of definite articles by linking their emergence to the need of flagging attentional shifts in utterance-by-utterance processing of discourse.
Quality control for next-generation liquefaction case histories

Author(s): Stewart, Jonathan; Zimmaro, Paolo; Brandenberg, Scott J; Bozorgnia, Yousef; Kwak, Dong Youp; Cetin, Kemal Onder; Can, G; Ilgac, M; Franke, Kevin W; Moss, Robb ES; Kramer, Steven L; Stamatakos, John; Juckett, Miriam; Weaver, Thomas | Editor(s): Silvestri, Francesco; Moraci, Nicola | Abstract: The Next-Generation Liquefaction (NGL) database is an open-source, global database of liquefaction and non-ground failure case-histories. The database is part of a multi-year research effort with the main goal of developing improved procedures to evaluate liquefaction susceptibility, triggering, and consequences. In NGL, a case-history is defined as the intersection of three components: (1) a site, (2) an earthquake event, and (3) post-earthquake observations. The NGL database hosts case-histories used to develop existing liquefaction models, as well as new data derived from recent earthquakes such as the 2010-2011 Canterbury earthquake sequence, the 2011 Tohoku-Oki earthquake, and the 2012 Emilia earthquake. The database also hosts lateral spread case-histories, and a substantial number of liquefaction sites characterized by the presence of co-located recording stations. All of the data present in the NGL database are reviewed by the NGL Database Working Group. The NGL formal vetting process is described for an example case-history.
Enhancing Long Term Fairness in Recommendations with Variational Autoencoders

Recommender systems have become indispensable for several Web sites, helping users deal with big amounts of data. They are capable of analyzing user/item interactions taking place on-line, and provide each user with a list of suggestions sorted by relevance. Items with the same or very close relevance, however, may occupy different positions in the ranking and may be exposed to completely different levels of attention. This promotes unfair treatment and can only be addressed by a long term strategy. Variational Autoencoders (VAEs) were recently proposed as the state-of-the-art for collaborative filtering recommendations, but as every other approach, they generate homogeneous prediction scores among the highest positions. In this paper, we propose incorporating randomness in the regular operation of VAEs in order to increase the fairness (mitigate the position bias) in multiple rounds of recommendation. We argue that adding a noise component when sampling values from VAE's latent representation provides long term fairness, despite of a tolerable decrease in ranking quality (NDCG). We calculate the trade-off between unfairness and NDCG when introducing 4 different noise distributions. The solution has proved to be a very practical one and the results point for a clear positive effect of turning recommendation far more fair, despite some small NDCG loss in Movie Lens, Netflix and MSD datasets. In our best scenario, the unfairness was reduced by 76% despite a decrease of 5% in the quality of ranking.
The use of Elliptic Curve Cryptography in DNSSEC

The RFC 6605 introduced the modern cryptography based on elliptic curves into DNSSEC. This document explains what are the advantages, and the few disadvantages, to switch from current DSA/RSA keys and signatures to Elliptic Curve Cryptography. Modular Group Cryptography Some Maths All objects here are based on an abstract algebraic structure named a field in English, un corps in French, ein Körper in German. In fact definitions are different but give in the finite case the same objects with p elements, p being a prime, noted Fpk or GF (p ), with the common addition and multiplication modulo p. In the finite field Fp, the elements at the exception of 0 form a group for the multiplication, so for any a the set {1, a, a, . } is a cyclic subgroup with a number of elements which divides (by Lagrange’s theorem) the number of elements of the whole group, i.e., p − 1, so for instance a ≡ 1 (mod p) when p is a prime (as known as the Fermat’s little theorem). Diffie-Hellman example The Diffie-Hellman protocol is the simplest application of these maths to cryptography. Take a big prime p so p−1 2 is also prime, and a base g so the
CMAR_A_170380 5271..5291

Division of Medical Oncology, Department of Medicine, Keck School of Medicine and Translational and Clinical Science Program, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA Abstract: In recent years, new therapeutic options have become available for prostate cancer (PC) patients, generating an urgent need for better biomarkers to guide the choice of therapy and monitor treatment response. Liquid biopsies, including circulating tumor cells (CTCs), circulating nucleic acids, and exosomes, have been developed as minimally invasive assays allowing oncologists to monitor PC patients with real-time cellular or molecular information. While CTC counts remain the most extensively validated prognostic biomarker to monitor treatment response, recent advances demonstrate that CTC morphology and androgen receptor characterization can provide additional information to guide the choice of treatment. Characterization of cell-free DNA (cfDNA) is another rapidly emerging field with novel technologies capable of monitoring the evolution of treatment relevant alterations such as those in DNA damage repair genes for poly (ADP-ribose) polymerase (PARP) inhibition. In addition, several new liquid biopsy fields are emerging, including the characterization of heterogeneity, CTC RNA sequencing, the culture and xenografting of CTCs, and the characterization of extracellular vesicles (EVs) and circulating microRNAs. This review describes the clinical utilization of liquid biopsies in the management of PC patients and emerging liquid biopsy technologies with the potential to advance personalized cancer therapy.
Terahertz-Band MIMO Systems: Adaptive Transmission and Blind Parameter Estimation

We consider the problem of efficient blind parameter estimation in terahertz (THz)-band ultra-massive multiple-input multiple-output (UM-MIMO) systems. UM-MIMO antenna arrays are crucial to overcoming the distance problem in THz communications. Following recent advancements in THz transceiver design, such arrays are intrinsically compact and reconfigurable. We propose dynamically tuning the modulation types, operating frequencies, and indices of transmitting antenna elements for efficient resource utilization in THz UM-MIMO systems. Furthermore, we propose THz-specific signal processing techniques at the receiver side for blindly detecting the transmission parameters. In particular, we propose a low-complexity antenna index, frequency index, modulation mode, and modulation type detectors, and we study the complexity and performance tradeoffs of the proposed schemes.