Miracle-dz/UniFAR-FTUs huggingface dataset:
Histórias que fazem sentidos: as determinações das alterações vocais do professor

Attending district teachers who show vocal alterations, I note that there are diverse factors shaping and operating such alterations. Such evidence made me develop this very investigation, which has the objective to study the diverse manners in which a teacher in Sao Paulo’s school system itemizes the work conditions. So these might act as built-in components of its voice symptom. As a system, we use life stories to learn the meaning of voice alteration for every teacher. Based on the analysis of deposition, the following aspects were considered: the idealization of the teacher’s role, the conditions of the schools, the quest for therapy treatment and the functional readaptation. Finally, I suggest that any health professional who take in as a guest the teacher, face the vocal alterations as a suffering, starting with the idea of worning out, not in a reduced concept of environmental and biological conditions, but takes into account the subjective dimension of the daily confrontations.
Nota sobre la paleoecología del yacimiento de Libros (Teruel) en relación con los Artrópodos y las plantas fósiles del biotopo

Se estudian dos Coleopteros en estado adulto y dos larvas atribuibles a este Orden asi como un Diptero y un Araneido. Todos ellos son citados por primera vez en Espana. Se clasifica tambien un resto foliar y se compara con las determinaciones hechas por otros autores en el mismo yacimiento, sacandose conclusiones de orden paleogeografico en relacion con los yacimientos espanoles y europeos del mismo y proximos niveles.
The Texas Medication Algorithm Project: report of the Texas Consensus Conference Panel on Medication Treatment of Major Depressive Disorder.

BACKGROUND This article describes the development of consensus medication algorithms for the treatment of patients with major depressive disorder in the Texas public mental health system. To the best of our knowledge, the Texas Medication Algorithm Project (TMAP) is the first attempt to develop and prospectively evaluate consensus-based medication algorithms for the treatment of individuals with severe and persistent mental illnesses. The goals of the algorithm project are to increase the consistency of appropriate treatment of major depressive disorder and to improve clinical outcomes of patients with the disorder. METHOD A consensus conference composed of academic clinicians and researchers, practicing clinicians, administrators, consumers, and families was convened to develop evidence-based consensus algorithms for the pharmacotherapy of major depressive disorder in the Texas mental health system. After a series of presentations and panel discussions, the consensus panel met and drafted the algorithms. RESULTS The panel consensually agreed on algorithms developed for both nonpsychotic and psychotic depression. The algorithms consist of systematic strategies to define appropriate treatment interventions and tactics to assure optimal implementation of the strategies. Subsequent to the consensus process, the algorithms were further modified and expanded iteratively to facilitate implementation on a local basis. CONCLUSION These algorithms serve as the initial foundation for the development and implementation of medication treatment algorithms for patients treated in public mental health systems. Specific issues related to adaptation, implementation, feasibility testing, and evaluation of outcomes with the pharmacotherapeutic algorithms will be described in future articles.
Parameter extraction methodology for SOI-LDMOS transistors

A parameter extraction methodology to estimate the values of parameters corresponding to a highly accurate static compact model of a laterally double diffused metal oxide semiconductor (LDMOS) transistor is proposed. The model essentially consists of three voltage dependent current sources representing three regions in an LDMOS transistor. The extraction methodology is based on the idea that effects of few specific parameters dominate in the terminal characteristics in specific bias regimes. The LDMOS transistor is biased in different operating regions of the output characteristics to allow different data analysis for extracting specific sets of model parameters. The proposed methodology is validated by comparing the results of the compact model simulation using the extracted parameters with the numerical simulation data from MEDICI.
Von der (Un-)Möglichkeit ausgeglichener Haushalte

Staatsverschuldung wird hier als ein negativer externer Effekt verstanden, den Politiker ausuben, um die Kosten ihres politischen Angebots zu senken und somit im politischen Wettbewerb bestehen zu konnen. Die Gegebenheiten des politischen Wettbewerbs und die Moglichkeit diesen externen Effekt auszuuben, versetzen die Politiker in eine Dilemma-Situation, welche die Vermeidung von Defiziten, also eine Zusammenarbeit zum allgemeinen Vorteil, unmoglich macht und zwangslaufig zu immer neuen Defiziten fuhrt. Ausnahmen ergeben sich nur, wenn die Kosten der Staatsverschuldung internalisiert werden. Da eine vollstandige Internalisierung uber den Markt aber in der Regel nicht gelingen kann, wird eine erfolgreiche Bekampfung des Verschuldungsproblems nur mit Hilfe von Regulierung gelingen. Wir pladieren daher fur eine Kombination aus Intensivierung des Wettbewerbs, um eine verstarkte Internalisierung der negativen externen Effekte zu erreichen, und Kanalisierung des Wettbewerbs, also Regulierung, um den Einsatz von Staatsverschuldung zu begrenzen und die Dilemmastruktur aufzubrechen.
Identification of Putative Fallopian Tube Stem Cells

Stem cells are used to repair and regenerate multiple tissues in the adult. We have previously shown that stem cells play a significant role in mediating endometrial repair and tissue regeneration. We hypothesized that the oviduct may possess a similar population of stem cells that contribute to the maintenance of this tissue. Here we identify label-retaining cells (LRCs) in the murine oviduct which indicate the presence of a stem/progenitor cell population in this tissue as well. Two-day-old CD-1 mice were injected intraperitoneally with 5-bromo-2-deoxyuridine (BrdU) or vehicle control. Female animals (n = 36 for each group) were killed at 6 weeks post injection. Reproductive tracts were removed, specimens were embedded in paraffin, and 5-µ sections were prepared. Oviduct was identified by hematoxylin and eosin staining and morphology. Immunofluorescence studies were performed on serial sections tissues (n = 12 per animal) using antibodies against BrdU. Confocal microscopy was used to identify 4′,6-diamidino-2-phenylindole (DAPI)- and BrdU-stained nuclei. In the group of mice exposed to BrdU, we identified a population of LRCs in all specimens and not in controls. The putative stem cells are located at the base of each villi, suggesting the location of the stem cell niche. The number of DAPI-stained nuclei divided by the number of LRCs; LRCs constituted 0.5% of all nucleated cells. The oviduct contains a population of progenitor cells, likely used in the repair and regeneration of fallopian tube. Defective or insufficient stem cell reserve may underlie common tubal diseases, including hydrosalpinx and ectopic pregnancy.
Knowledge-Based Scoring Functions in Drug Design: 3. A Two-Dimensional Knowledge-Based Hydrogen-Bonding Potential for the Prediction of Protein-Ligand Interactions

Hydrogen bonding is a key contributor to the molecular recognition between ligands and their host molecules in biological systems. Here we develop a novel orientation-dependent hydrogen bonding potential based on the geometric characteristics of hydrogen bonds observed in 44,585 protein-ligand complexes. We find a close correspondence between the empirical knowledge and the energy landscape inferred from the distribution of HBs. A scoring function based on the resultant hydrogen-bonding potentials discriminates native protein-ligand structures from incorrectly docked decoys with remarkable predictive power.
Measuring desire for death among patients with HIV/AIDS: the schedule of attitudes toward hastened death.

OBJECTIVE As physician-assisted suicide is debated, a need for standardized measurement of desire for death among medically ill individuals has emerged. The authors present preliminary validation data for a new self-report instrument, the Schedule of Attitudes Toward Hastened Death. METHOD The participants were 195 patients with HIV/AIDS from two sites: 148 ambulatory patients and 47 patients who had been recently admitted to a facility for end-of-life care. The ambulatory participants completed the 20-item Schedule of Attitudes Toward Hastened Death and several other instruments, including the Beck Depression Inventory and Brief Symptom Inventory. The terminally ill patients also completed the Schedule of Attitudes Toward Hastened Death, along with other measures, and were assessed by clinicians with the Hamilton Depression Rating Scale and the Desire for Death Rating Scale, a global clinician rating of the patient's desire for death. RESULTS The Schedule of Attitudes Toward Hastened Death demonstrated high reliability. The total score significantly correlated with the clinician rating on the Desire for Death Rating Scale and with ratings of depression and psychological distress. In addition, the Schedule of Attitudes Toward Hastened Death score significantly correlated with pain intensity and physical symptom distress. Factor analysis supported a single factor structure for the instrument. CONCLUSIONS These results indicate that the Schedule of Attitudes Toward Hastened Death is a reliable, valid measure of desire for death among patients with HIV/AIDS. Further research with this measure may help address many of the unanswered questions emerging from the ongoing debates regarding legalization of assisted suicide.
microRNAs in Parkinson’s Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches

Parkinson’s disease (PD) is the most prevalent central nervous system (CNS) movement disorder and the second most common neurodegenerative disease overall. PD is characterized by the progressive loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc) within the midbrain, accumulation of alpha-synuclein (α-SYN) in Lewy bodies and neurites and excessive neuroinflammation. The neurodegenerative processes typically begin decades before the appearance of clinical symptoms. Therefore, the diagnosis is achievable only when the majority of the relevant DAergic neurons have already died and for that reason available treatments are only palliative at best. The causes and mechanism(s) of this devastating disease are ill-defined but complex interactions between genetic susceptibility and environmental factors are considered major contributors to the etiology of PD. In addition to the role of classical gene mutations in PD, the importance of regulatory elements modulating gene expression has been increasingly recognized. One example is the critical role played by microRNAs (miRNAs) in the development and homeostasis of distinct populations of neurons within the CNS and, in particular, in the context of PD. Recent reports demonstrate how distinct miRNAs are involved in the regulation of PD genes, whereas profiling approaches are unveiling variations in the abundance of certain miRNAs possibly relevant either to the onset or to the progression of the disease. In this review, we provide an overview of the miRNAs recently found to be implicated in PD etiology, with particular focus on their potential relevance as PD biomarkers, as well as their possible use in PD targeted therapy.
Gene Transfer into the Medfly, Ceratitis capitata, with a Drosophila hydei Transposable Element

Exogenous functional DNA was introduced into the germline chromosomes of the Mediterranean fruit fly (medfly) Ceratitis capitata with a germline transformation system based on the transposable element Minos from Drosophila hydei. Transformants were identified as phenotypic revertants of a white-eyed mutation carried by the recipient strain. Clusters of transformants were detected among the progeny of 390 individuals screened for germline transformation. Five independent and phenotypically active integration events were identified, in each of which a single copy of the transposon was inserted into a different site of the medfly genome. Molecular analysis indicates that they represent transposase-mediated insertions of the transposon into medfly chromosomes.
Bone development in the jaw of Nile tilapia Oreochromis niloticus (Pisces: Cichlidae)

East African cichlids have evolved feeding apparatus morphologies adapted to their diverse feeding behaviors. The evolution of the oral jaw morphologies is accomplished by the diversity of bone formation during development. To further understand this evolutionary process, we examined the skeletal elements of the jaw and their temporal and sequential emergence, categorized by developmental stages, using the Nile tilapia Oreochromis niloticus as a model cichlid. We found that chondrogenesis started in Stage 17. The deposition of osteoid for the dermal bones commenced in Stage 18. The uptake of calcium dramatically shifted from the surface of larvae to the gills in Stage 20. The bone mineralization of the skeleton began in Stage 25. These data provide important information regarding the sequential events of craniofacial development in East African cichlids and lay the groundwork for studying the molecular mechanisms underlying adaptation of jaw structure to feeding behavior.
Influence of carbohydrate solubility on non-protein nitrogen utilization in the ruminant.

Although soluble carbohydrates and carbohydrate solubility may sound synonymous, they, in fact, are not when one considers their influence upon the fermentat ion in the rumen. The former refers to a restricted class of carbohydrates of specified solubility whereas the latter portrays a characteristic of any carbohydrate or group of carbohydrates that often can be modified by pH and concentration as well as by chemical, physical, and microbial processing techniques. As such, the lat ter characteristic becomes more critical in a discussion of effects on non-protein nitrogen (NPN) utilization. This review is in no way an exhaustive review of the effects o f all forms of carbohydrate or NPN utilization. The subject of NPN utilization has been reviewed many times, most recently by Helmer and Bartley (1971). Far too many of the li terature citations which could be cited represent repetitive findings which contr ibute very litt le definitive or new information to our information bank on NPN utilization. References quoted herein are primarily for the purpose of setting the stage for the ideas and challenges to be presented. In effect then, the purpose of this paper is to stimulate the future investigators of this topic to (1) investigate newer, more novel areas of research, (2) accept the challenge of improving research techniques so that really new information can be obtained using them, and concurrently, (3) abandon those techniques which, although traditional, are not particularly definitive and are often a waste of t ime and effort.
Microneedling: Advances and widening horizons

Microneedling is a very simple, safe, effective, and minimally invasive therapeutic technique. It was initially introduced for skin rejuvenation, however, now it is being used for a very wide range of indications including acne scar, acne, post-traumatic/burn scar, alopecia, skin rejuvenation, drug delivery, hyperhidrosis, stretch marks, and many more. Moreover, during the last 10 years, many new innovations have been made to the initial instrument, which was used for microneedling. This technique can be combined with other surgical techniques to provide better results. In particular, it is a very safe technique for dark skin types, where risk of postinflammatory pigmentation is very high with other techniques that damage the epidermis. In this review article, we are updating on the different instruments now available for this procedure, and its efficacy when performed alone or in combination with other techniques for various indications.
Theoretische Fragestellungen zur Bewertung von Unternehmen

Die vorliegende Dissertationsschrift beschaftigt sich mit theoretischen Fragestellungen der Finanzwissenschaft im Bereich des Asset Pricing und im Detail der Unternehmensbewertung. Dabei wird sowohl auf Problemstellungen der akademischen und praxisnahen Forschung eingegangen. Der erste Artikel beschaftigt sich mit der Fragestellung welche Implikationen die Annahme einer arithmetischen Brownschen Bewegung auf bestimmte Aspekte der Unternehmensbewertung hat. Es folgen drei Artikel die sich auf unterschiedlicher Weise mit der Zinsschrankenregelung auseinandersetzen. Die darauf folgenden zwei Artikel behandeln hauptsachlich die Modellierung von Insolvenz im Rahmen der Unternehmensbewertung bei Annahme verschiedener Finanzierungspolitiken. Der achte Artikel geht naher auf die Thematik der empirischen Bestatigung bestimmter Kapitalstrukturtheorien ein. Die Dissertation schliest mit einem Artikel zu wichtigen Parametern fur die Unternehmensbewertung. Theoretische Fragestellungen zur Bewertung von Unternehmen Kumulative Inauguraldissertation zur Erlangung des Doktorgrades der Wirtschaftswissenschaften (Dr. rer. oec.) an der HHL Leipzig Graduate School of Management Jahnallee 59, 04109 Leipzig, Deutschland vorgelegt von Dipl. -Vw. Alexander D. F. Lahmann Leipzig, am 28. September 2012 Betreuer & Erstgutachter: Prof. Dr. Bernhard Schwetzler, CVA Lehrstuhl fur Finanzmanagement und Banken Zweitgutachter: Prof. Dr. Henning Zulch Lehrstuhl fur Rechnungswesen, Wirtschaftsprufung und Controlling
Development of Powered Knee Prosthesis with Small-Scale, Light-Weight, and Affordable Series-Elastic Actuator, and its Preliminary Walking Test

Powered knee prosthesis improves locomotion of above-knee amputees by generating net positive mechanical work at the knee joint which is especially required for movements with active knee extension and flexion such as sit-to-stand maneuvers, level-ground walking with various walking speed, stair/slope ascent ambulation and so forth. However, powered prosthesis is composed of a large number of mechanical and electrical components becoming more bulky, heavy-weight and expensive than traditional passive and quasi passive prosthesis. In this study, a powered knee prosthesis with small-scale, light-weight and affordable series elastic actuator (PKP-SEA) is developed and tested on one above knee amputee. He walks on a treadmill at walking speed of 0.8m/s on the PKP-SEA and a conventional knee prosthesis and knee joint biomechanics is analyzed. As a result, the PKP-SEA shows capability of torque control for natural walking gait by imitating damper and spring function like a conventional prosthetic knee joint.
Wafer-Scale Statistical Analysis of Graphene FETs—Part I: Wafer-Scale Fabrication and Yield Analysis

Wafer-scale, CMOS compatible graphene transfer has been established for device fabrication and can be integrated into a conventional CMOS process flow back end of the line. In Part I of this paper, statistical analysis of graphene FET (GFET) devices fabricated on wafer scale is presented. Device yield is approximately 75% (for 4500 devices) measured in terms of the quality of the top gate, oxide layer, and graphene channel. Statistical evaluation of the device yield reveals that device failure occurs primarily during the graphene transfer step. In Part II of this paper, device statistics are further examined to reveal the primary mechanism behind device failure. The analysis from Part II suggests that significant improvements to device yield, variability, and performance can be achieved through mitigation of compressive strain introduced in the graphene layer during the graphene transfer process. The combined analyses from Parts I and II present an overview of mechanisms influencing GFET behavior as well as device yield. These mechanisms include residues on the graphene surface, tears, cracks, contact resistance at the graphene/metal interface, gate leakage as well as the effects of postprocessing.
Inhibitory Effects of Secondary Metabolites from the Red Alga Delisea pulchra on Swarming Motility of Proteus mirabilis

Abnormal, uncoordinated swarming motility of the opportunistic human pathogen Proteus mirabilis was seen when a crude extract of the Australian red alga Delisea pulchra was added to the medium. This occurred at concentrations at which growth rate, swimming motility, cell elongation, polynucleation, and hyperflagellation were not affected. One halogenated furanone from D. pulchra inhibited swarming motility at concentrations that did not affect growth rate and swimming motility. Other structurally similar D. pulchra furanones had no effect on swarming, suggesting considerable specificity in the effects of furanones on swarming motility by P. mirabilis.
Robust Optimization Based Optimal DG Placement in Microgrids

This paper proposes a novel Microgrid (MG) planning methodology to decide optimal locations, sizes and mix of dispatchable and intermittent distributed generators (DGs). The long-term costs in the proposed planning model include investment, operation and maintenance (O&M), fuel and emission costs of DGs while the revenue includes payment by MG loads and utility grid. The problem is formulated as a mixed-integer program (MIP) considering the probabilistic nature of DG outputs and load consumption, wherein the costs are minimized and profits are maximized. The model is transformed to be a two-stage robust optimization problem. A column and constraint generation (CCG) framework is used to solve the problem. Compared with conventional MG planning approaches, the proposed model is more practical in that it fully considers the system uncertainties and only requires a deterministic uncertainty set, rather than a probability distribution of uncertain data which is difficult to obtain. Case studies of a MG with wind turbines, photovoltaic generators (PVs) and microturbines (MTs) demonstrate the effectiveness of the proposed methodology.
De politieke strategieën van autofabrikanten ten opzichte van milieubeleid in Californië

Vanwege het belang van een duurzamer vervoerssysteem worden geregeld beleidsinterventies toegepast om gevestigde autofabrikanten nieuwe, schone voertuigtechnologieen te laten ontwikkelen. Gevestigde autofabrikanten hebben in het verleden zulke beleidsinterventies echter vaak tegengehouden of vertraagd. Een van de meest ingrijpende beleidsinterventies ter verduurzaming van het vervoerssysteem is het ‘Zero Emission Vehicle’ (ZEV) mandaat in Californie. Wij onderzochten hoe gevestigde autofabrikanten en coalities van autofabrikanten hun politieke strategieen met betrekking tot dit mandaat veranderden in de periode van 2000 tot 2013. Voor het inzichtelijk maken van bedrijfspolitieke strategieen en de onderliggende tactieken en acties maken we gebruik van de ‘Corporate Political Activities’ literatuur. Onze longitudinale case studie put uit een database bestaande uit 263 documenten en rapporten, 5 transcripties van openbare hoorzittingen, 61 brieven van de auto-industrie en 16 aanvullende interviews met betrokkenen. We ontdekten dat autofabrikanten in de bestudeerde periode steeds minder defensief en meer proactief en nalevend worden in hun politieke strategieen ten opzichte van het mandaat. De coalities van autofabrikanten blijven echter relatief defensief in hun politieke acties; zij blijven het ‘vuile werk’ van de autofabrikanten doen. Met deze studie bieden we inzicht in de bedrijfspolitieke activiteiten die autofabrikanten gebruiken om beleidsmakers te beinvloeden. Om met de oppositie vanuit de industrie tegen beleidsinterventies om te gaan, suggereert dit onderzoek dat wanneer beleidsmakers de industrie willen raadplegen, zij vooral met de individuele bedrijven in gesprek moeten gaan in plaats van met coalities van bedrijven zoals