Miracle-dz/UniFAR-FTUs huggingface dataset:
Versatile bioactive and antibacterial coating system based on silica, gentamicin, and chitosan_ Improving early stage performance of titanium implants

The aim of this work is to develop and characterize a multifunctional and dual surface coating system for titanium orthopedic implants by applying two different cost-effective, scalable, and non-complex coating technologies (spray and electrophoretic deposition). The first deposit is formed by a sprayed hybrid sol-gel layer combined with bioactive glass particles (45S5, BG), and the outer part of the dual coating consists of a chitosangelatin/silica (Si) antibiotic (gentamicin, Ge) composite layer applied by electrophoretic deposition. The application of sol-gel enclosed BG drops onto the surface was done to enhance the bioactivity of the double-layered surface coating system. After the BG is dissolved, thus generating a calcium‐silicon rich medium, the re-deposition of hydroxyl‐carbonate apatite occurs. Regarding the antibacterial inhibition properties, antibacterial activity to both strains used (S. aureus and E. coli) was obtained for the chitosan/gelatin/SieGe nanoparticle coatings on titanium substrates, showing a large inhibition area around the samples. Both the bare Ti samples and the coatings with chitosan/gelatin matrix did not successfully inhibit bacterial growth. As expected, the presence of silica-based glasses and coatings based on amorphous silica enhanced cell viability. The deposition of BG was done with the aim of extending the bioactive effect of the system, considering the presence of a porous degradable organic layer deposited on top, which was shown to be partially degraded after 7 days. The sol gel sprayed BG layer combined with chitosan/gelatin biopolymers filled with SieGe nanoparticles presents a suitable technology to generate bioactive and antibacterial surfaces to enhance Ti implant performance.
An Ontological Analysis and Natural Language Processing of Figures of Speech

The purpose of the current paper is to present an ontological analysis to the identification of a particular type of prepositional figures of speech via the identification of inconsistencies in ontological concepts. Prepositional noun phrases are used widely in a multiplicity of domains to describe real world events and activities. However, one aspect that makes a prepositional noun phrase poetical is that the latter suggests a semantic relationship between concepts that does not exist in the real world. The current paper shows that a set of rules based on WordNet classes and an ontology representing human behaviour and properties, can be used to identify figures of speech due to the discrepancies in the semantic relations of the concepts involved. Based on this realization, the paper describes a method for determining poetic vs. non-poetic prepositional figures of speech, using WordNet class hierarchies. The paper also addresses the problem of inconsistency resulting from the assertion of figures of speech in ontological knowledge bases, identifying the problems involved in their representation. Finally, it discusses how a contextualized approach might help to resolve this problem.
Small gaps between primes 1 2

This paper describes the authors’ joint research on small gaps between primes in the last 4 decade and how their methods were developed further independently by Zhang, Maynard, and Tao to 5 prove stunning new results on primes. We now know that there are infinitely many primes differing by 6 at most 246, and that one can find k primes a bounded distance (depending on k) apart infinitely often. 7 These results confirm important approximations to the Hardy–Littlewood Prime Tuples Conjecture. 8 Mathematics Subject Classification (2010). Primary 11N05, 11N36; Secondary 11N35. 9
1.5: Sphingolipids

Sphingolipids are a type of lipids made up of fatty acid chains that were first mentioned in 1884 in J.L. W. Thudichum’s A Treatise on the chemical composition of the brain. They were named after the Greek mythological creature, the sphinx, due to the unknown riddle of their function. [1] Sphingolipids are found in essentially all plants, animals, fungi and in some prokaryotes and viruses. Specifically, they are found in membranes and as a major component of lipoproteins. [2]
Angle Closure Glaucoma

Purpose: To determine the rate of anatomical closure and visual outcome following vitreous surgery for idiopathic macular hole (IMH) using Optical Coherence Tomography (OCT). Methods: Interventional case series. 23 eyes with idiopathic macular hole having a preoperative OCT macular hole diameter ranging from 280 to 1051 microns underwent vitrectomy with internal limiting membrane peeling and perfluoropropane gas injection. Outcome measures: Primary outcome: Anatomical closure of macular hole demonstrated by OCT. Secondary outcome measures: Visual acuity and complications. Results: Type I closure was seen in 14 eyes and type II closure was seen in 7 eyes. Anatomical closure was not achieved in 2 eyes with macular hole diameter of greater than 400 microns. Conclusion: OCT measurements are useful to predict the anatomical and visual outcomes following surgery for idiopathic macular hole.
Effect of Formulation Variables and Gamma Sterilization on Transcorneal Permeation and Stability of Proniosomal Gels as Ocular Platforms for Antiglaucomal Drug

This study aims to evaluate the effect of different formulation variables (surfactant type and HLB value) adopting full factorial design (51. 21) using coacervation phase technique on in vitro characterization of dorzolamide hydrochloride (DZ)-loaded proniosomal gels, namely, entrapment efficiency percentage (EE%), vesicle size distribution, polydispersion index (PDI), and in vitro DZ release. The optimum formula F2 with a desirability value of 0.937 composed of 40 mg DZ, 500 mg span 60, 500 mg of L-α-Lethicin, and 55.5 mg cholesterol showing EE% of 84.5 ± 1.5%, PS of 189.5 ± 35.76 nm with PDI 0.8 ± 0.28 and 58.51% ± 1.00 of DZ released after 8 h was further evaluated using differential scanning calorimetry (DSC) and transmission electron microscopy (TEM). The effect of gamma sterilization on transcorneal permeation and stability of DZ from the selected formulation (F2) revealed that F2 was significantly tolerable, stable, and competent to corneal permeation confirmed by histological examination, confocal laser microscopy, and intraocular pressure (IOP) measurement. Significant corneal bioavailability was attained from formula F2 (370.6 mg. h/m) compared to the market product Trusopt® eye drops (92.59 mg. h/ml) following IOP measurement, thereby proniosomal gels could be considered as tolerable and competent ocular platforms for improving the transcorneal permeation of DZ.
ARTÍCULO ORIGINAL: EVOLUCIÓN CLÍNICA DE LOS PACIENTES CON DIABETES MELLITUS SOMETIDOS A ANGIOPLASTÍA CORONARIA CON IMPLANTACIÓN DE STENT DE ENERO A DICIEMBRE DEL 2009 EN EL HOSPITAL SAN

Background: Percutaneous coronary angioplasty (PTCA) with stent placement is both safe and effective interventional treatment for ischemic heart disease. This disease has a high prevalence and impact in the morbidity and mortality in the general population. The purpose of this study is to describe the outcomes obtained with PTCA/stent terapy at the San Juan de Dios Hospital during the period between January 2009 and December 2009. Methodology: A descriptive, retrospective and observational study was performed by collecting information from medical files of 268 patients treated with PTCA during the study period. An analysis of the outcomes was performed on those patients that met inclusion criteria. Results: We included 88 diabetic patients (62 males and 26 females). 18,3% of the patients had dyslipidemia, 49,8% were smokers and 87,5% had hypertension. In relation with previous procedures, 12,5% of the patients had one previous angioplasty and 2,3% had by-pass surgery. On average there were 1,4 ± 0,6 vessels treated, with a minimum of 1 vessel and a maximum of 3 vessels. On average there were 1,7 ± 1,0 stents per patient, with a minimum of one and a maximum of five stents. The number of stents per treated vessel was 1,3. Medicated stents were used in 89,4% of the cases. Succesful PTCA accounted for 96,6% of the individuals (85 cases), and only 6 patients (6,8%) had procedure-related complications. Major cardiovascular events after PTCA ocurred un 23 patients (26,1%). Twenty-three patients (26,1%) had major cardiovascular events after PTCA, and 39,1% of these, required another PTCA. There were two patients who were trated for two different lesions (9,33%) and 4,5% of the patients had re-estenosis. A 3,4% (3 cases) die after the procedure due to cardiovascular causes (two cases because of cardiogenic shock and one case because of advanced coronary artery disease). The first two died during the first month after the procedure and the other one died one year after the angioplastic procedure. Conclusion: Diabetic patients had higher risk of thrombosis, restenosis, reintervention and overall mortality on both groups of stents.
The game analysis of the optimal configuration strategy of the intrusion detection system and intrusion detection system

With the increasingly rampant intrusion, it is found that it is not enough to construct the security system from the Angle of defense. On how the computer and network resources malicious use behavior recognition and response, proposes the web application level intrusion detection defense system and intrusion detection system, the optimal allocation strategy game analysis. By comparison with literature analysis method, this paper expounded the basic structure of the intrusion detection system, using the game theory to establish virtual private networks (VPNS) and intrusion detection system model of information security technology combination, design companies and hackers mixed strategy Nash equilibrium in the game model analysis, and applied to the example analysis. The study finds that the manual survey strategy configured with two technologies was the same as when IDS is configured separately. Under certain conditions, it is better to configure two technical combinations to prevent hackers from intruding.
InsightVis: Staff Dashboard for a Third-Year Software Engineering Course

Large classrooms place a high demand on course staff who are often strained for time. Course instructors need to be able to make informed decisions about course changes, and teaching assistants need quick access to information that helps them support students. To this end, we developed InsightVis, a dashboard to improve access to information for course staff of UBC’s Introduction to Software Engineering. It features a class view that provides an overview of the whole class and supports broad analytics, and a team view to show a team’s current and historical progress on developing their course project. InsightVis will be integrated into the currently used Classy course management system used by the course.
Damages and causative factors of 2015 strong Nepal Earthquake and directional movements of infrastructures in the Kathmandu Basin and along the Araniko Highway

The strong earthquake on April 25, 2015 (7.8 Mw) and the aftershock on May 12, 2015 (7.3 Mw) claimed the lives of 8,659 people, plus 21,150 people injured and huge economic loss together with serious damages on eight World Heritage sites. Our two field surveys in the month of from May 9-21, 2015 and 19-23 July, 2015 revealed understanding of damages to traditional towns, historical monuments, and modern buildings. Regionally, damages on buildings are confined to the traditional houses which are remnants of or renovated after the 8.1 magnitude 1934 AD earthquake. Widespread cases of inadequate engineering and construction practices for RCC (Reinforced Cement Concrete) buildings and renovated old buildings have been severely affected. The affected region includes the main shock along the 150 km long rupture zone towards east. The aftershock reached farther south at a shallower depth towards the end of the eastern rupture zone. As a result damages inflicted in the structures from both quakes revealed different shaking directions. The April 25 main shock caused eastward leaning structures while May 12 aftershock caused southward leaning and/collapsed structures. It is important to identify whether the direction is due to aftershock at the end of initial rupture zone or if it represents a newly exposed fault.
Improving Learning Outcomes with Gaze Tracking and Automatic Question Generation

As AI technology advances, it offers promising opportunities to improve educational outcomes when integrated with an overall learning experience. We investigate forward-looking interactive reading experiences that leverage both automatic question generation and analysis of attention signals, such as gaze tracking, to improve short- and long-term learning outcomes. We aim to expand the known pedagogical benefits of adjunct questions to more general reading scenarios, by investigating the benefits of adjunct questions generated after participants attend to passages in an article, based on their gaze behavior. We also compare the effectiveness of manually-written questions with those produced by Automatic Question Generation (AQG). We further investigate gaze and reading patterns indicative of low vs. high learning in both short- and long-term scenarios (one-week followup). We show AQG-generated adjunct questions have promise as a way to scale to a wide variety of reading material where the cost of manually curating questions may be prohibitive.
On the three-dimensional bin packing using rotations

One of the most interesting variations of the problem of the 3-Dimensional Bin Packing Problem (3BPP) is the determination of the minimum number of three-dimensional rectangular bins that are required for orthogonally allocating a given set of three-dimensional rectangular items without overlap and minimizing the occupied space: the 3BPP–min problem. This is, of course, yet another NP-Hard multi-criteria combinatorial optimization. One of the most obvious applications for this problem is the one that occurs daily in warehouses management systems, either by using manual or automatic packing. We present a new approach for the 3BPP–min problem where 90 degrees rotations are allowed in order to allow for a more compact packing. Most of the known heuristic solutions for this type of packing are based on the well-known works of Martello, Pisinger and Vigo. Boschetti has recently introduced new lower bounds specifically tailored for packing using the possibility of rotations of items that we used for designing the new heuristic algorithm. This algorithm uses both this new lower bounds and the theory of non-dominated solutions for deciding on the best packing for a 3BPP–min instance. Computational results show the effectiveness of the new approximation algorithm that shows to be faster and achieve lower occupation of space, thus, better compaction.
Biogeographic context mediates multifaceted diversity-productivity relationships in island and mainland forests

Aim Growing evidence suggests that impacts of biodiversity loss on ecosystem functioning and nature’s contributions to people are usually negative, yet the magnitude and direction of these impacts can be variable across naturally-assembled ecosystems. A potential driver of variation in diversity-productivity relationships is the biogeographical context, which may alter these relationships via processes acting on the size and composition of the species pool like dispersal limitation, environmental filtering, speciation, and invasibility. However, the extent to which the relationships between biodiversity facets and forest productivity are shaped by the biogeographic context remains uncertain. Here, we examine the effects of taxonomic, phylogenetic, and functional tree diversity on aboveground productivity in climatically similar forests on islands and mainland. Location Continental and insular Spain. Time period 1997-2018. Major taxa studied Trees. Methods Using plot data from a national forest inventory, we assessed the influence of taxonomic, phylogenetic, and functional diversity on aboveground productivity using linear models and structural equation models, while accounting for environmental conditions, non-native species, and the number of trees. Results We find that drier environmental conditions lead to a decrease in productivity and in the number of trees in both island and mainland forests. In island forests, non-native species increased productivity directly and via their effects on phylogenetic diversity. Main conclusions Our results suggest that multifaceted diversity, by capturing the diversity of evolutionary history, contributes to elucidating diversity-productivity relationships in island forests that could not be detected otherwise by taxonomic diversity alone. By filling empty niches in island forests, we find that non-native species are fundamentally altering ecosystem functioning on islands.
On the Relationship between Software Complexity and Security

This work aims at discussing the complexity aspect of software while demonstrating its relationship with security. Complexity is an essential part of software; however, numerous studies indicate that they increase the vulnerability of the software systems and introduce bugs in the program. Many developers face difficulty when trying to understand the complex components of software. Complexity in software increases when objects in the software are used to design a more complex object while creating a hierarchical complexity in the system. However, it is necessary for the developers to strive for minimum complexity, as increased complexity introduces security risks in the software, which can cause severe monetary and reputational damage to a government or a private organization. It even causes bodily harm to human beings with various examples found in previous years where security breaches led to severe consequences. Hence it is vital to maintain low complexity and simple design of structure. Various developers tend to introduce deliberate complexities in the system so that they do not have to write the same program twice; however, it is getting problematic for the software organizations as the demands of security are continually increasing.
Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3 and Reducing STAT3

Tumor growth, progression, and therapy resistance are crucial factors in the prognosis of cancer. Properties of three-dimensional (3D) tumor-like organoids (tumoroids) more closely resemble in vivo tumors compared to two-dimensionally cultured cells and are therefore effectively used for assays and drug screening. We here established a repurposed drug for novel anticancer research and therapeutics using a 3D tumoroid-based screening system. We screened 6 pharmacologically active compounds by using an original tumoroid-based multiplex phenotypic screening system with matrix metalloproteinase 9 (MMP9) promoter-driven fluorescence reporter for the evaluation of both tumoroid formation and progression. Antiparkinson drug benztropine was the most effective compound uncovered by the screen. Benztropine significantly inhibited in vitro tumoroid formation, cancer cell survival, and MMP9 promoter activity. Benztropine also reduced the activity of oncogenic signaling transducers and trans-activators for MMP9, including STAT3, NF-κB, and β-catenin, and properties of cancer stem cells / cancer-initiating cells. Benztropine and GBR-12935 directly targeted the dopamine transporter DAT/SLC6A3, whose genetic alterations such as amplification were correlated with poor prognosis for cancer patients. Benztropine also inhibited tumor growth, circulating tumor cell (CTC) number, and rate of metastasis in a tumor allograft model in mice. In conclusion, we propose the repurposing of benztropine for anticancer research and therapeutics that can suppress tumor progression, CTC, and metastasis of aggressive cancers by reducing key pro-tumorigenic factors.
To Fire or Not to Fire ? The Role of Job Security in Asset Management *

Does job security affect employees’ incentives and performance, and if so, in which direction? I study the causal effect of job security in the setting of asset management and exploit a novel quasinatural experiment: When an asset management firm’s external subcontractor is involved in regulatory misconduct, the firm becomes less likely to terminate its internal funds and fund managers, resulting in exogenously increased job security for fund managers inside the firm. Using a difference-in-differences approach, I find that fund managers experiencing increased job security deliver lower performance, especially those who care less about their reputation in the labor market. Furthermore, I show that the firm provides higher pay-for-performance as an imperfect substitute to incentivize employees when internal job security exogenously increases. Overall, my results suggest that higher job security disincentivizes employees and can negatively affect productivity. *I am grateful to my dissertation committee, Massimo Massa (Chair), Frederico Belo, and Hong Zhang for their valuable guidance and support. I thank Aleksandar Andonov, Vladimir Asriyan, Matthieu Bouvard, Vincent Glode, Naveen Gondhi, Torsten Jochem, John Kuong, Juhani Linnainmaa, Lars Lochstoer, Joel Peress, Theo Vermaelen, Johan Walden, Yu Yang, Pengfei Ye, as well as participants at LBS Trans-Atlantic Doctoral Conference, Northern Finance Association Conference, PBC School of Finance Workshop, Amsterdam Business School Brown Bag, and INSEAD Brown Bag for helpful discussions and valuable comments. Any errors are my own. †INSEAD, Boulevard de Constance, 77305 Fontainebleau Cedex, France; E-mail: yijun.zhou@insead.edu
The Moderating Role of Government Support on The Relationship between Owner Characteristic and E-Commerce Adoption by Micro Enterprises

Electronic commerce (e-commerce) is one of the ways for micro enterprises to compete in promoting and selling products. But, the use of internet to sell products online by micro enterprises is still low. This study aims to investigate those factors that influence micro enterprises in adopting e-commerce from owner characteristics and the moderating role of government support on the relationship between owner characteristics and e-commerce adoption. Data were obtained from 100 respondents in Jabodetabek Region which are taken by purposive sampling method. Data were analyzed using Partial Least Square (PLS). Based on the results, it was found that owner characteristics have positive effect to e-commerce adoption. The interaction between government support and owner characteristics has no significant effect on the e-commerce adoption. Thus it can be concluded that there is no moderating role of goverment support on the relationship between owner characteristics and e-commerce adoption.