Miracle-dz/UniFAR-FTUs huggingface dataset:
EGU General Assembly 2010 参加報告

(1) Departamento de Medio Ambiente, CIEMAT, Madrid, Spain (esther.coz@ciemat.es), (2) Instituto de Diagnóstico Ambiental y Estudios del Agua (IDÆA), CSIC, Barcelona, Spain, (3) RJ Lee Group, Inc., Monroeville, Pennsylvania, USA, (4) Center for Atmospheric Particle Studies, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA, (5) Laboratory of Atmospheric Chemistry, Paul Scherrer Institute, Villigen PSI, Switzerland
Analyse entropico-logarithmique de séquences vidéo couleur : application a la segmentation et au suivi de visages parlants

Ces dernieres annees ont vu un renforcement dans l'interet porte a la representation de visages parlants de syntheses. Les applications d'un tel systeme sont nombreuses et pas encore totalement definies : visiophonie, compression mpeg, clone-assistant de synthese, aide aux personnes handicapees cependant, alors que les methodes de synthese de visage sont de plus en plus fideles, le traitement d'image n'est pas actuellement en mesure de proposer des methodes robustes et de bonne qualite en analyse de visage. Ce travail de recherche porte donc sur l'analyse et l'extraction de parametres geometriques du visage. L'approche retenue considere une premiere segmentation couleur spatio-temporelle de la sequence du locuteur, localise et mesure ensuite sur le visage des caracteristiques geometriques. En raison des conditions de prise de vues non supervisees sur le locuteur ou l'eclairage (webcam, sequence televisee), un espace logarithmique couleur particulier et une approche par seuillage entropique du mouvement ont ete developpes. Par la suite, une segmentation hierarchique par champs de markov combine informations de teinte et de mouvement dans un voisinage spatio-temporel approprie. Les differentes regions du visage sont ainsi extraites automatiquement. Finalement, la qualite des resultats obtenus autorise l'extraction et le suivi du visage dans un scene, le suivi et la mesure geometrique du contour de zones faciales telles que les levres ou les yeux par contours actifs.
S1P mediates human amniotic cells proliferation induced by a 50‐Hz magnetic field exposure via ERK1/2 signaling pathway

Extremely low frequency electromagnetic field (ELF‐EMF) is a kind of physical stimulus in public and occupational environment. Numerous studies have indicated that exposure of cells to ELF‐EMF could promote cell proliferation. But the detailed mechanisms implicated in these proliferative processes remain unclear. In the present experiment, the possible roles of sphingosine‐1‐phosphate (S1P) in 50‐Hz magnetic field (MF)‐induced cell proliferation were investigated. Results showed that exposure of human amniotic (FL) cells to a 50‐Hz MF with an intensity of 0.4 mT significantly enhanced ceramide metabolism, increased S1P production, activated extracellular signal regulated kinase 1/2 (ERK1/2), and promoted cell proliferation. All of these effects induced by MF exposure could be inhibited by SKI II, an inhibitor of sphingosine kinase (SphK). In addition, both the cell proliferative response and the ERK1/2 activation induced by MF exposure were blocked completely by U0126, a specific inhibitor of MEK (ERK kinases 1 and 2). Taken together, the findings in present study suggested that S1P mediated 50‐Hz MF‐induced cell proliferation via triggering ERK1/2 signal pathway.
Efficacy and safety of the dual SYK/JAK inhibitor cerdulatinib in patients with relapsed or refractory B‐cell malignancies: Results of a phase I study

This work was supported by the Intramural Research Programs of the National Heart, Lung, and Blood Institute and the National Institute of Diabetes and Digestive and Kidney Diseases. We thank Global Blood Therapeutics for the gift of Voxelotor used in this study, the Department of Transfusion Medicine (DTM) at the NIH for transfusion support and Dr. Joshua Lehrer for helpful discussion and sharing results of unpublished work. We thank Dr. Jay Lozier and Frank H. Bunn for helpful discussions.
Évaluation de parcours d’exposition : une approche par indicateurs spatiaux et temporels

A partir d’une evaluation realisee au musee des Ursulines de Quebec, l’auteur presente les outils, les principaux objectifs et les resultats d’une methodologie permettant de comparer, a partir de l’organisation de l’espace et de la trame narrative de l’exposition, le parcours ideal propose par l’institution museale et le parcours vecu observe du visiteur.
Effect of ultrasonic activation on dentinal tubule penetration of calcium silicate‐based cements

This study investigated the dentinal tubule penetration of mineral trioxide aggregate (MTA), NeoMTA Plus and Biodentine placed by either manual condensation or ultrasonic activation in simulated open apex model. Standardized divergent open apex models were created using palatal roots of 60 human maxillary molars and divided into six groups according to the used cements and activation methods (n = 10): MTA‐manual condensation, MTA‐ultrasonic activation, NeoMTA Plus‐manual condensation, NeoMTA Plus‐ultrasonic activation, Biodentine‐manual condensation, Biodentine‐ultrasonic activation. For the measurement of penetration, the cements were mixed with 0.1% Rhodamin B and 6‐mm apical portions of each root canal were obturated in an orthograde direction. The roots were embedded into acrylic blocks, and 1‐mm‐thick sections were obtained at 3 mm from the apex. Specimens were mounted onto glass slides and scanned under a confocal laser scanning microscope (CLSM) and stereomicroscope. Dentinal tubule penetration areas, depth and percentage were measured using LSM and ImageJ software. The data were analyzed using two‐way analysis of variance (anova) with Bonferroni correction (α = 0.05). No correlation was found between stereomicroscope and CLSM analyses (p > .05). CLSM analysis showed no significant differences between MTA, NeoMTA Plus, and Biodentine groups when manual condensation was used (p > .05). Ultrasonic activation did not increase the tubular penetration of MTA, NeoMTA Plus or Biodentine as compared to manual condensation of each material (p > .05). MTA, NeoMTA Plus and Biodentine showed similar tubular penetration when manual condensation was used. Ultrasonic activation of these cements had no effect on tubular penetration of each material as compared to the manual condensation counterparts.
Respiratory Variability of Pulmonary Velocity-Time Integral As a New Gauge of Fluid Responsiveness For Mechanically Ventilated Patients in the ICU*

Objectives: To evaluate reliability and feasibility of the respiratory variability of pulmonary velocity-time integral as a new dynamic marker of fluid responsiveness in mechanically ventilated patients. Design: Prospective observational study. Setting: Medical-surgical ICU of a general hospital. Patients: Fifty mechanically ventilated patients with acute circulatory failure. Interventions: Transthoracic echocardiography was performed at inclusion (transthoracic echocardiography baseline). Fluid therapy was prescribed to patients exhibiting one value greater than or equal to 13% among commonly used variables of fluid responsiveness: respiratory variability of aortic velocity-time integral, respiratory variability of inferior vena cava diameter, or pulse pressure variation. Measurements and Main Results: Respiratory variability of pulmonary velocity-time integral was assessed at baseline. Respiratory variability of pulmonary velocity-time integral was significantly greater in patients who received fluid therapy (26.9 ± 12.5% vs 6.2 ± 4.3%; p < 0.0001). Respiratory variability of pulmonary velocity-time integral was correlated with respiratory variability of aortic velocity-time integral (r = 0.75; p < 0.0001), respiratory variability of inferior vena cava diameter (r = 0.42; p < 0.01), and pulse pressure variation (r = 0.87; p < 0.0001) at baseline and with the relative increase in cardiac output after fluid therapy (r = 0.44; p = 0.019). Fluid responsiveness was defined as a 10% increase in cardiac output after fluid therapy, assessed by a second transthoracic echocardiography. Respiratory variability of pulmonary velocity-time integral was associated with fluid responsiveness (adjusted odds ratio, 1.58; 95% CI, 1.08–2.32; p = 0.002). Area under the receiver operating characteristics curve was 0.972, and a value of respiratory variability of pulmonary velocity-time integral greater than or equal to 14% yielded a sensitivity of 92% and specificity of 87% to predict fluid responsiveness. Interobserver reproducibility was excellent (intraclass correlation coefficient = 0.94). Conclusions: Respiratory variability of pulmonary velocity-time integral is a simple and reliable marker of fluid responsiveness for ventilated patients in ICU.
Postpartum Period Is a Risk Factor for Cerebral Venous Thrombosis: A Case-Control Study

Background and Purpose— Pregnancy and the postpartum period are generally considered to be risk factors for cerebral venous thrombosis (CVT), but no controlled studies have quantified the risk. Methods— Case-control study using data of consecutive adult patients with CVT from 5 academic hospitals and controls from the Dutch MEGA study (Multiple Environmental and Genetic Assessment of risk factors for venous thrombosis). Men, women over the age of 50, women using oral contraceptives or with a recent abortion or miscarriage were excluded. We adjusted for age and history of cancer, and stratified for pregnancy versus postpartum, and 0 to 6 versus 7 to 12 weeks postpartum. Results— In total 163/813 cases and 1230/6296 controls were included. Cases were younger (median 38 versus 41 years) and more often had a history of cancer (14% versus 4%) than controls. In total 41/163 (25%) cases and 82/1230 (7%) controls were pregnant or postpartum (adjusted odds ratio, 3.8; 95% CI, 2.4–6.0). The association was fully attributable to an increased risk of CVT during the postpartum period (adjusted odds ratio, 10.6; 95% CI, 5.6–20.0). We found no association between pregnancy and CVT (adjusted odds ratio, 1.2; 95% CI, 0.6–2.3). The risk was highest during the first 6 weeks postpartum (adjusted odds ratio, 18.7; 95% CI, 8.3–41.9). Conclusions— Women who have recently delivered are at increased risk of developing CVT, while there does not seem to be an increased risk of CVT during pregnancy.
Reflex Tongue Protrusion as a Novel Release Phenomenon in Dementia in Adulthood

A 79-year-old right-handed man diagnosed with Alzheimer’s dementia nine years prior and living in a nursing home was admitted to hospital with respiratory sepsis. On examination, he was globally aphasic and not obeying commands. Incidentally, when any object was seen to approach his mouth, there was involuntary and immediate anterior protrusion of the tongue followed by withdrawal of the tongue back into the mouth (Video 1). This abnormal movement was stereotypical and highly reproducible. Grasp, snout, and palmomental reflexes were also present. Deep tendon reflexes were present and normal throughout. Plantar reflexes were downgoing. There were no obvious cranial nerve deficits. There was no evidence of extrapyramidal signs (i.e., chorea, dystonia, dyskinesia, myoclonus, bradykinesia or rigidity). Although unable to coordinate the use of a straw, the patient was able to chew and swallow effectively, maintaining a soft diet with regular fluids without overt signs of aspiration or unintentional weight loss. Magnetic resonance imaging of the brain showed generalized atrophy without lobar predominance, and chronic microvascular ischaemia without restricted diffusion or contrast enhancement.
Can current molecular tests help in the diagnosis of indeterminate thyroid nodule FNAB?

ABSTRACT Approximately 15–30% of all thyroid nodules evaluated with fine-needle aspiration biopsy (FNAB) are classified as cytologically indeterminate. The stepwise unraveling of the molecular etiology of thyroid nodules has provided the basis for a better understanding of indeterminate samples and an opportunity to decrease diagnostic surgery in this group of patients. Over the last 15 years, several studies have tested different methodologies to detect somatic mutations (by polymerase chain reaction and next-generation sequencing, for example), and to identify differentially expressed genes or microRNA, aiming at developing molecular tests to improve the presurgical diagnosis of cytologically indeterminate nodules. In this review, we will provide an overview of the currently available molecular tests and the impact of mutation testing on the diagnosis of thyroid cancer. We will also review current published data and future perspectives in molecular testing of thyroid nodule FNAB and describe the current Brazilian experience with this diagnostic approach. Based on currently available data, especially for countries outside the US-Europe axis, a rational use of these tests must be made to avoid errors with regard to test indication and interpretation of test outcomes. In addition to clinical, radiological, and cytological features, we still need to determine local malignancy rates and conduct more independent validation and comparative performance studies of these tests before including them into our routine approach to indeterminate FNAB.
Evaluation of microbial proliferation on cementitious materials exposed to biogas systems

ABSTRACT Understanding the interactions between biofilm and cementitious materials in biogas production systems is an essential step toward the development of durable concrete for this expanding sector. Although the action of the liquid phase medium on the material has been the subject of several research studies, the possible impact of the material’s properties on biofilm formation and composition has been little investigated, if at all. The aim of this paper is to evaluate the characteristics of the biofilm according to the surface properties of the materials. Four cementitious materials with different chemical and mineralogical compositions, and various topological surface characteristics (pastes of CEM I, CEM III/C and CAC, and CEM I paste treated with oxalic acid) were exposed to the liquid phase of a fermenting biowaste for 10 weeks. The steps of biofilm formation were observed using SEM. Even though all the cementitious material surfaces were intensely colonized at the end of the experiments, the establishment of the biofilm seems to have been delayed on the oxalate-treated CEM I and on CAC coupons. Roughness and surface pH effects were not of prime importance for the biofilm development. The analysis of bacterial population diversity using 16S rDNA sequencing showed a less diversified microbial flora in the biofilm than in the reaction medium. GRAPHICAL ABSTRACT
Assessing Enhancement Technologies: Authenticity as a Social Virtue and Experiment

This paper argues for a revised concept of authenticity entailing two demands that must be balanced. The first demand moves authenticity from the position of a strictly self-regarding virtue towards the position of a fully social virtue, acknowledging the crucial feature of steadiness, i.e. self-consistency, as being precisely what we ‘naturally’ lack (Williams). Nevertheless, the value of personal authenticity in a modern, open society comes from the fact that it brings about not only steadiness, but also the public development of a variety of existential options that can be understood as Millian ‘original experiments in living’. Thus the second demand of authenticity is a demand for ‘experimental’ authenticity which covers the whole spectrum of technologies of the self, from Nietzschean ‘brief habits’, to the use of enhancement technologies.
Sex differences in schizophrenia, bipolar disorder, and post‐traumatic stress disorder: Are gonadal hormones the link?

In this review, we describe the sex differences in prevalence, onset, symptom profiles, and disease outcome that are evident in schizophrenia, bipolar disorder, and post‐traumatic stress disorder. Women with schizophrenia tend to exhibit less disease impairment than men. By contrast, women with post‐traumatic stress disorder are more affected than men. The most likely candidates to explain these sex differences are gonadal hormones. This review details the clinical evidence that oestradiol and progesterone are dysregulated in these psychiatric disorders. Notably, existing data on oestradiol, and to a lesser extent, progesterone, suggest that low levels of these hormones may increase the risk of disease development and worsen symptom severity. We argue that future studies require a more inclusive, considered analysis of gonadal steroid hormones and the intricacies of the interactions between them, with methodological rigour applied, to enhance our understanding of the roles of steroid hormones in psychiatric disorders.
Diagnosis Prevalence and Comorbidity in a Population of Mobile Integrated Community Health Care Patients

Abstract Introduction Frequent calls to 911 and requests for emergency services by individuals place a costly burden on emergency response systems and emergency departments (EDs) in the United States. Many of the calls by these individuals are non-emergent exacerbations of chronic conditions and could be treated more effectively and cost efficiently through another health care service. Mobile integrated community health (MICH) programs present a possible partial solution to the over-utilization of emergency services by addressing factors which contribute to a patient’s likelihood of frequent Emergency Medical Services (EMS) use. To provide effective care to eligible individuals, MICH providers must have a working understanding of the common conditions they will encounter. Objective The purpose of this descriptive study was to evaluate the diagnosis prevalence and comorbidity among participants in the Queen Anne’s County (Maryland USA) MICH Program. This fundamental knowledge of the most common medical conditions within the MICH Program will inform future mobile integrated health programs and providers. Methods This study examined preliminary data from the MICH Program, as well as 2017 Maryland census data. It involved secondary analysis of de-identified patient records and descriptive statistical analysis of the disease prevalence, degree of comorbidity, insurance coverage, and demographic characteristics among 97 program participants. Diagnoses were grouped by their ICD-9 classification codes to determine the most common categories of medical conditions. Multiple linear regression models and chi-squared tests were used to assess the association between age, sex, race, ICD-9 diagnosis groups, and comorbidity among program enrollees. Results Results indicated the most prevalent diagnoses included hypertension, high cholesterol, esophageal reflux, and diabetes mellitus. Additionally, 94.85% of MICH patients were comorbid; the number of comorbidities per patient ranged from one to 13 conditions, with a mean of 5.88 diagnoses per patient (SD=2.74). Conclusion Overall, patients in the MICH Program are decidedly medically complex and may be well-suited to additional community intervention to better manage their many conditions. The potential for MICH programs to simultaneously improve patient outcomes and reduce health care costs by expanding into larger public health and addressing the needs of the most vulnerable citizens warrants further study. ScharfBM, BissellRA, TrevittJL, JenkinsJL. Diagnosis prevalence and comorbidity in a population of mobile integrated community health care patients. Prehosp Disaster Med. 2019;34(1):46–55.
First trimester 3D ultrasound placental volume for predicting preeclampsia and/or intrauterine growth restriction

Abstract The objective of the study was to determine the sensitivity of the placental volume for predicting preeclampsia and/or intrauterine growth restriction (IUGR) in the first trimester. A prospective observational study was conducted in pregnant women with a gestational age of 11 to 13+6 weeks. A 3 D transabdominal placental volume measurement was performed at the time of first-trimester aneuploidy screening. The predictive values of this test were calculated. The data from 360 pregnant women was analysed. Seventeen cases developed preeclampsia and/or IUGR. The 10th percentile of placental volume was used as the cut-off level. The sensitivity, specificity, positive predictive value and negative predictive value of placental volume less than the 10th percentile for prediction of preeclampsia and/or IUGR were 23.5%, 90.7%, 11.1% and 96%, respectively. The sensitivity, specificity, positive predictive value and negative predictive value for prediction of early onset preeclampsia were 50%, 90.7%, 3.0% and 99.7%, respectively. This study demonstrated that the placental volume was lower in the cases with preeclampsia and/or IUGR. It was not an effective screening tool for preeclampsia and/or IUGR in the first trimester. IMPACT STATEMENT What is already known on this subject? Placental volume may reflect trophoblast invasion, but much earlier, in the first trimester. The estimation of a smaller early placental volume has been shown to be significantly associated with preeclampsia and IUGR. What do the results of this study add? The placental volume was lower in the cases with preeclampsia and/or IUGR. It was not an effective screening tool for preeclampsia and/or IUGR in the first trimester. But it might be used for predicting early onset preeclampsia. What are the implications of these findings for clinical practice and/or further research? Further research of placental volume in the first trimester for predicting an early onset preeclampsia should be conducted.
Bystander programs addressing sexual violence on college campuses: A reply to Mindthoff, Stephens, and Madhivanan

that this particular study would not have been included in the meta-analysis because it was not a test of a college campus bystander program. This should have been presented more clearly in our review article. After taking into consideration the critiques made in the Mindthoff et al. paper and revisiting our quantitative analysis of the studies that were identified for this particular meta-analytic review, we found no basis for altering the conclusions presented in the original Jouriles et al. report. Conflict of interest disclosure The authors have no conflicts of interest to report.
Role of lactic acid on cognitive functions

ABSTRACT Objectives: The aim of this research was to establish cognitive changes in relation to blood lactate levels obtained during slow performance of a regimen of exercise sessions. Methods: A total of 15 male professional bodybuilders participated in the study; CrossFit® professionals performed the Workout 15.5, Week 5 Open 2015 consisting of 27-21-15-9 repetitions for time of Row (calories) and Thrusters, with 1-min recovery. Blood lactate, blood glucose, reaction time (RT), execution time of a dual cognitive task, number of errors, and number of omissions were measured at rest, at conclusion of the session, and after recovery for 15 min. Results: The bodybuilders had slightly elevated basal lactate levels than in untrained individuals. The bodybuilders showed significantly increased lactacidemia and decreased RT after completing the training session. Need to define what onset of blood lactate accumulation (OBLA) means. Conclusion: We conclude that bodybuilding fitness regimens lead to an increase in basal lactate levels to 3.16 mmol/L and that acute training sessions can improve attentional performance in relation to lactacidemia, suggesting pro-cognitive effects of a workout.