Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling of High Frequency Noise in SOI MOSFETs

The high frequency thermal noise sets the lower limit ofthe detectable signals in the receiver RF front-end systems.Hence it is very important that the models for thermal noiseshould be more accurate and physical. In this paper, wemodel thermal noise with BSIMSOI and PSPSOI modelsand compare it with the hardware data. The comparison isdone for two types of FET:thick gate-oxide NFET(5.2 nm)and thin gate-oxide NFET(3.2 nm). The hardware correlationbetween the PSPSOI and BSIMSOI models are comparedand the PSPSOI model is found to model the hardwaredata more accurately. The noise performance betweenthe thin oxide and thick oxide NFETs are compared and thethin oxide FET has been found to have a better noise performance.
Characterisation of wireless network traffic: Fractality and stationarity

Fractality and stationarity of a wireless network has been investigated in this paper by revealing the scaling pattern and nature of frequency fluctuation of the two vital parameters, the daily peak hour call arrival number and daily call drop number (03. 03.2004 to 31.10.2013), of a sub-urban local mobile switching centre, using some statistical methodologies. To have the knowledge about the fractality, Hurst Exponent for the series have been calculated using the methodologies like Visibility Graph Analysis, Higuchi's Fractal Dimension and General Hurst Estimation. It has been noticed that both the time series exhibit Short Range Dependent (SRD) anti-persistent behavior. Smoothed Pseudo Wigner-Ville Distribution (SPWVD) method has been used to unearth the stationarity/non-stationarity of the data-series where daily drop call time series shows evidence of non-stationary character while the busy hour call initiation series behave in a stationary manner.
Ein monetäres Makromodell für die Lehre

Im traditionellen IS-LM-AS-Modell der Makroökonomie ist die Geldmenge eine exogene Instrumentvariable der Notenbank. Dieser Modelltyp wird zunehmend durch Neukeynesianische Modelle, wie das kürzlich in dieser Zeitschrift präsentierte BMW-Modell, ersetzt. Darin kommt die Geldmenge nicht vor, der monetäre Sektor wird nur durch eine zinspolitische Reaktionsfunktion berücksichtigt. In diesem Beitrag wird ein monetäres Makromodell (RST-Modell) vorgestellt, das den Geldmarkt vollständig abbildet und in dem die Geldmenge einen Einfluss auf die Preisentwicklung hat.
Genome Sequences of Multidrug-Resistant, Colistin-Susceptible and -Resistant Klebsiella pneumoniae Clinical Isolates from Pakistan

ABSTRACT The emergence and spread of colistin resistance among multidrug-resistant (MDR) Klebsiella pneumoniae represent a critical threat to global health. Here, we report the complete genome sequences of 10 MDR, colistin-susceptible and -resistant K. pneumoniae clinical isolates obtained in Pakistan between 2010 and 2013.
Lessons from the central Hampshire electronic health record pilot project: issues of data protection and consent

One of the key elements of the NHS information strategy of 1998 was the development of electronic patient records.1 These were expected to be developed within organisations and to be capable of being linked into a patient focused electronic health record, which would form a lifetime record of health and health care for each patient within the NHS.1 This vision has been modified slightly by updates of the strategy, and the electronic health record has been renamed and redefined as the NHS Care Record Service, but in many ways the original concept has remained the same.2 The purpose of the electronic health record—now the NHS Care Record Service—is twofold. Firstly, to provide support for the clinical team to help them recall and communicate health status and treatments for patients in a coordinated way, and, secondly, to act as the source of statistical information on types of patients seen and the process and outcomes of their treatment. Although there was much expectation that these goals could be achieved, there was little evidence to prove that this was the case for the original strategy and its subsequent refreshes.2 For that reason, the NHS Information Authority sponsored 18 pilot projects which ran from April 2000 to March 2003 to test the concepts in several locations. The central Hampshire electronic health record pilot project was supported from September 2000 to March 2003. During that time it evaluated the practicality of linking records from a wide range of organisations to support emergency and out of hours care, as well as providing information that could support data analysis and clinical governance. The project, originally based at North and Mid-Hampshire Health Authority, linked with several key organisations within the area, which included three general practices (one in Eastleigh and Test Valley South primary …
Biofeedback is superior to laxatives for normal transit constipation due to pelvic floor dyssynergia.

BACKGROUND & AIMS Uncontrolled trials suggest biofeedback is an effective treatment for pelvic floor dyssynergia (PFD), a type of constipation defined by paradoxical contraction, or inability to relax, pelvic floor muscles during defecation. The aim was to compare biofeedback to laxatives plus education. METHODS Patients with chronic, severe PFD were first treated with 20 g/day fiber plus enemas or suppositories up to twice weekly. Nonresponders were randomized to either 5 weekly biofeedback sessions (n = 54) or polyethylene glycol 14.6-29.2 g/day plus 5 weekly counseling sessions in preventing constipation (n = 55). Satisfaction with treatment, symptoms of constipation, and pelvic floor physiology were assessed 6 and 12 months later. The biofeedback group was also assessed at 24 months. Laxative-treated patients were instructed to increase the dose of polyethylene glycol from 14.6 to 29.2 g/day after 6 months. RESULTS At 6 months, major improvement was reported by 43 of 54 (80%) biofeedback patients vs 12 of 55 (22%) laxative-treated patients (P < .001). Biofeedback's benefits were sustained at 12 and 24 months. Biofeedback also produced greater reductions in straining, sensations of incomplete evacuation and anorectal blockage, use of enemas and suppositories, and abdominal pain (all P < .01). Stool frequency increased in both groups. All biofeedback-treated patients reporting major improvement were able to relax the pelvic floor and defecate a 50-mL balloon at 6 and 12 months. CONCLUSIONS Five biofeedback sessions are more effective than continuous polyethylene glycol for treating PFD, and benefits last at least 2 years. Biofeedback should become the treatment of choice for this common and easily diagnosed type of constipation.
A high background light subtraction circuit for long range time-of-flight cameras

In this paper, a background light subtraction circuit is presented for a long range time-of-flight camera in outdoor applications. A low (de)modulation frequency is used for long range estimation, which saturates the photodiode due to integration of high-intensity background light. Therefore, long range cameras are generally limited to indoor applications. In this work, a circuit is proposed to subtract up to 120 klx BGL for 1.07–9.65 m distance. A (de)modulation frequency of 2.33 MHz with 33 % duty-cycle is used. The measurement results show a range resolution of 1.49 cm and 65 cm for 1.07 m and 9.65 m distance, respectively at 120 klx background light. The circuit is fabricated and characterized in UMC 180 nm technology.
Control of Ser2448 Phosphorylation in the Mammalian Target of Rapamycin by Insulin and Skeletal Muscle Load*

We have investigated the effects of insulin, amino acids, and the degree of muscle loading on the phosphorylation of Ser2448, a site in the mammalian target of rapamycin (mTOR) phosphorylated by protein kinase B (PKB)in vitro. Phosphorylation was assessed by immunoblotting with a phosphospecific antibody (anti-Ser(P)2448) and with mTAb1, an activating antibody whose binding is inhibited by phosphorylation in the region of mTOR that contains Ser2448. Incubating rat diaphragm muscles with insulin increased Ser2448 phosphorylation but did not change the total amount of mTOR. Insulin, but not amino acids, activated PKB, as evidenced by increased phosphorylation of both Ser308 and Thr473 in the kinase. Ser2448 phosphorylation was also modulated by muscle-loading. Overloading the rat plantaris muscle by synergist muscle ablation, which promotes hypertrophy of the plantaris muscle, increased Ser2448 phosphorylation. In contrast, unloading the gastrocnemius muscle by hindlimb suspension, which promotes atrophy of the muscle, decreased Ser2448phosphorylation, an effect that was fully reversible. Neither overloading nor hindlimb suspension significantly changed the total amount of mTOR. In summary, our results demonstrate that atrophy and hypertrophy of skeletal muscle are associated with decreases and increases in Ser2448 phosphorylation, suggesting that modulation of this site may have an important role in the control of protein synthesis.
Dynamical Systems Guided Design and Analysis of Silicon Oscillators for Central Pattern Generators

In this paper, a dynamical systems (DS) approach is proposed for the analysis and design of bio-inspired silicon central pattern generator (CPG) systems. Based on this approach, a new leaky-integrate-and-leaky-discharge oscillator circuit is proposed that has dynamical properties closer to biological half-center oscillators while being power and area efficient. The membrane potential charges and discharges through a single resistor eliminating mismatch in charging and discharging phases. Switched-capacitor (SC) and floating-gate wide input linear range operational transconductance amplifier (FGOTA) based approaches have been proposed to implement the resistor. Both approaches enable controllable and large resistances in a small area. Oscillation frequency can be easily controlled by the frequency of switching in SC based and bias current in FGOTA based implementations, which are very useful for global change of oscillation frequency in an array of oscillators. Dynamical systems analysis has shown that when it is used as a single oscillator, the proposed circuit is able to produce a phase response curve (PRC) close to that of a lamprey CPG system. By applying averaging theory to a system of coupled oscillators, the averaged H and G functions for unidirectional and bidirectional coupling cases are obtained. Analysis of these functions shows our circuit's superior capability to achieve entrainment when driven by a periodic input (e.g., from sensory feedback) and reach equilibrium even with high frequency mismatch.
Rab11 Is a Useful Tool for the Diagnosis of Microvillous Inclusion Disease

Microvillous inclusion disease (MVID) is a congenital condition presenting with intractable diarrhea. Biopsies demonstrate abnormal apical PAS and CD10 staining in surface enterocytes correlating with the presence of characteristic cytoplasmic inclusions. MVID has been linked to mutations in myosin Vb, important in apical membrane recycling. Rab11 associates with myosin Vb in vesicle membranes and is also integral in recycling plasma membrane components. The authors performed Rab11 immunostaining on biopsies from 7 MVID cases, 10 normal small intestines, and 10 with chronic enteritis. In MVID cases, Rab11 showed diffuse apical cytoplasmic staining of surface enterocytes in a pattern similar to PAS and CD10, which was absent in all the 20 control cases. Ultrastructural examination confirmed localization to the external surface of MVID cytoplasmic inclusions. Rab11 staining may be a useful adjunct in MVID diagnosis and the results support that myosin Vb dysfunction is important in the pathogenesis of MVID.
Configuring Autopilot for Safe Flight and ROS Simulation Technical Report CSSE 1204

Unmanned Aerial Vehicles (UAV) are becoming an area of increasing interest. In particular, the use of autonomous UAVs is becoming the main concentration of much research. The use of autonomous UAVs presents very many opportunities, however, when flying multiple autonomous UAVs at once, collision avoidance becomes an issue. Therefore, collision avoidance algorithms must be implemented to allow multiple autonomous UAVs to fly concurrently without collisions. Testing these algorithms becomes abnormally expensive, due to the cost of these UAV’s. Thus a common practice involved with testing these algorithms involves using a simulator to analyze the effectiveness of certain algorithms before testing them on real systems. Unfortunately, simulators can only tell so much about an algorithm, and real flight tests are critical to solving problems that may not appear within the simulated environment.
The SAFE (SGRQ score, air-flow limitation and exercise tolerance) Index: a new composite score for the stratification of severity in chronic obstructive pulmonary disease

Background: This study was proposed to develop a composite of outcome measures using forced expiratory volume percentage of predicted, exercise capacity and quality of life scores for assessment of chronic obstructive pulmonary disease (COPD) severity. Materials and methods: Eighty-six patients with COPD were enrolled into a prospective, observational study at the respiratory outpatient clinic, National University Hospital Malaysia (Hospital Universiti Kebangsaan Malaysia - HUKM), Kuala Lumpur. Results: Our study found modest correlation between the forced expiratory volume in 1 s (FEV1), 6 min walk distance and the SGRQ scores with mean (SD) values of 0.97 (0.56) litres/s, 322 (87) m and 43.7 (23.6)%, respectively. K-Means cluster analysis identified four distinct clusters which reached statistical significance which was refined to develop a new cumulative staging system. The SAFE Index score correlated with the number of exacerbations in 2 years (r = 0.497, p<0.001). Conclusion: We have developed the SGRQ, Air-Flow limitation and Exercise tolerance Index (SAFE Index) for the stratification of severity in COPD. This index incorporates the SGRQ score, the FEV1 % predicted and the 6 min walk distance. The SAFE Index is moderately correlated with the number of disease exacerbations.
Simple broadband dual-polarized aperture-coupled microstrip antenna

This paper presents a simple broadband dual-polarized microstrip antenna with only three layers. The input impedance bandwidth (VSWR<2) of 25% is achieved with the double resonance technique, in which the resonant frequencies of the patch and the coupling slot are tuned near to each other. Proper positioning of the coupling slots and the use of a thin, medium permittivity substrate results in high isolation (>40 dB) between the ports and thus acceptable cross polarization (better than -20 dB). The geometry, return loss, and the isolation of a single antenna element and the radiation pattern of a four-element linear array are presented. These antennas were designed for the European DBS-band 10.70-12.75 GHz.
Prostaglandin H synthases, nonsteroidal antiinflammatory drugs, and colon cancer

Members of the structurally diverse class of drugs known as nonsteroidal anti‐inflammatory drugs (NSAIDs) have the ability to prevent or reduce the occurrence of colorectal, certain other gastrointestinal, and perhaps other cancers. The anticarcinogenic property of NSAIDs has been shown in epidemiological studies with humans and in experimental carcinogenesis studies with animals. In addition, clinical studies of the human disease familial adenomatous polyposis have demonstrated the efficacy of NSAIDs in mediating regression of colorectal adenomas. The mechanism of the anti‐carcinogenic effect of these drugs is not known, but most hypotheses have involved the common property of the NSAIDs to inhibit prostaglandin synthase (PHS) enzymes and thereby cause a subsequent reduction in levels of prostaglandins (PG) in tissue. Recent reports have questioned the role of PHS inhibition in the anticarcinogenic activity of NSAIDs by showing that some NSAID‐related compounds that are not PHS inhibitors can induce the same anticarcinogenic changes in cell cycle and apoptotic response as the PHS inhibitors. In this review we will examine the evidence that NSAIDs are anticarcinogenic, the evidence supporting PHS as the target of NSAIDs, and the evidence for and against inhibition of PG synthesis as the mechanism of cancer prevention by NSAIDs. —Levy, G. N. Prostaglandin H synthases, nonsteroidal anti‐inflammatory drugs, and colon cancer. FASEB J. 11, 234‐247 (1997)
Broadband widebeamwidth printed dipole antenna

A high-efficiency microstrip-fed angled-dipole antenna has been developed. The printed dipole with an integrated balun features a broad operating bandwidth. The simulation of the antenna show that 7.4-10.5GHz band with VSWR less than 2 is obtained, and gain is more than 4.8dB. With choosing the proper dipole arms angle and with a radome, we can get the widest E-plane and H-plane beamwidth. Comparing the proposed antenna to the similar antennas, it has a simple structure and a high gain, also the E-plane and H-plane beamwidth can reach about 101° and 108°. Wide beamwidth and high gain is obtained, which satisfies the application of wireless communication.
Pilot study of high-dose thiotepa and etoposide with autologous bone marrow rescue in children and young adults with recurrent CNS tumors. The Children's Cancer Group.

PURPOSE This study was designed to determine the toxicity, radiographic response rate, and outcome following high-dose thiotepa, etoposide, and autologous bone marrow rescue (ABMR) for young patients with recurrent malignant brain tumors. METHODS Eligibility criteria required adequate renal, hepatic, and pulmonary function, and no bone marrow infiltration. Thiotepa 300 mg/m2 and etoposide 500 mg/ m2 were infused on 3 consecutive days, and autologous bone marrow was infused 72 hours following chemotherapy. RESULTS Forty-five patients with recurrent high-grade brain tumors, aged 8 months to 36 years (median, 8 years), were treated. Seven patients (16%) died of treatment-related toxicities within 56 days of marrow reinfusion. Delayed platelet engraftment occurred in 44% of patients who survived beyond day 56. Of 35 patients with radiographically measurable disease who survived at least 28 days following ABMR, there were two complete responses (CRs) and six partial responses (PRs), for an overall response (CRs plus PRs) rate of 23% (SE = 7%). Objective responses were observed in four of 14 assessable patients with high-grade glioma and in two of six with primitive neuroectodermal tumors (PNETs)/ medulloblastoma. Survival was significantly improved in patients treated with minimal residual disease (P < .0005). Five of 18 patients (28%) with high-grade gliomas remain free of disease at 39+, 44+, 49+, 52+, and 59+ months post-ABMR. CONCLUSION The combination of high-dose thiotepa and etoposide has activity against a variety of recurrent childhood brain tumors. These results merit further evaluation in children and young adults with both recurrent and newly diagnosed high-grade brain tumors.
Adaptive Droop Resistance Technique for Adaptive Voltage Positioning in Boost DC–DC Converters

In this paper, an adaptive droop resistance (ADR) technique can compensate for the adaptive voltage positioning (AVP) control in a boost dc-dc converter. A loop analysis is derived with the AVP technique to show the effects of the right-half-plane (RHP) zero. When the value of RHP zero is above the equivalent series resistance (ESR) zero, constant output impedance can be guaranteed by the proposed compensation method. Once the value of RHP zero is below five times of ESR zero, the proposed ADR technique can vary the droop resistance to track the variation of the load current to increase the system stability. In case of load current variation, the output impedance is proven constant due to the implementation of the AVP technique in the boost converter. The transient response time is 22 μS when a 200-mA load current step occurs, which is faster than that of a conventional boost converter. Even at heavy loads, the ADR technique can ensure a fast and stable transient response without being affected by the RHP zero. The experimental results demonstrate that the proposed method can increase system stability and guarantee a fast transient response in the design of a boost converter with the AVP technique.
Trs20 is Required for TRAPP III Complex Assembly at the PAS and its Function in Autophagy

The modular TRAPP complex acts as a guanine‐nucleotide exchange factor (GEF) for Ypt/Rab GTPases. Whereas TRAPP I and TRAPP II regulate the exocytic pathway, TRAPP III functions in autophagy. The TRAPP subunit Trs20 is not required for assembly of core TRAPP or its Ypt1 GEF activity. Interestingly, mutations in the human functional ortholog of Trs20, Sedlin, cause spondyloepiphyseal dysplasia tarda (SEDT), a cartilage‐specific disorder. We have shown that Trs20 is required for TRAPP II assembly and identified a SEDT‐linked mutation, Trs20‐D46Y, which causes a defect in this process. Here we show that Trs20 is also required for assembly of TRAPP III at the pre‐autophagosomal structure (PAS). First, recombinant Trs85, a TRAPP III‐specific subunit, associates with TRAPP only in the presence of Trs20, but not Trs20‐D46Y mutant protein. Second, a TRAPP complex with Ypt1 GEF activity co‐precipitates with Trs85 from wild type, but not trs20ts mutant, cell lysates. Third, live‐cell colocalization analysis indicates that Trs85 recruits core TRAPP to the PAS via the linker protein Trs20. Finally, trs20ts mutant cells are defective in selective and non‐selective autophagy. Together, our results show that Trs20 plays a role as an adaptor in the assembly of TRAPP II and TRAPP III complexes, and the SEDT‐linked mutation causes a defect in both processes.
Downregulation of lncRNA X Inactive Specific Transcript (XIST) Suppresses Cell Proliferation and Enhances Radiosensitivity by Upregulating mir-29c in Nasopharyngeal Carcinoma Cells

Background LncRNA X inactive specific transcript (XIST) was reported to function as an oncogene in nasopharyngeal carcinoma cells (NPC) by sponging miR-34a-5p. However, the role of XIST in modulating the radiosensitivity of NPC cells and its mechanism still remain undefined. Material/Methods The expressions of XIST and miR-29c in NPC cells were evaluated by qRT-PCR. CNE1 and CNE2 cells were transfected with si-XIST, pcDNA-XIST, miR-29c mimics, anti-miR-29c, or respective controls by Lipofectamine 2000. The effects of XIST knockdown and miR-29c overexpression on cell proliferation, survival fraction, and γ-H2AX expression were investigated by CCK-8 assay, colony formation assay, immunofluorescence, and Western blot, respectively. Luciferase reporter assay and qRT-PCR analysis were performed to confirm whether XIST interacts with miR-29c and regulates its expression. Results XIST was upregulated and miR-29c was downregulated in NPC cells. The expressions of XIST and miR-29c changed reversely in response to irradiation. Knockdown of XIST and miR-29c overexpression both resulted in a dramatic suppression of cell proliferation, a marked enhancement of radiosensitivity, and an obvious increase of γ-H2AX foci formation in NPC cells. Luciferase reporter assay and qRT-PCR analysis demonstrated that XIST interacts with miR-29c and negatively regulates its expression. Moreover, miR-29c inhibition abrogated XIST knockdown-induced cell proliferation inhibition and radiosensitivity increase in NPC cells. Conclusions XIST knockdown suppressed cell proliferation and enhanced radiosensitivity of NPC cells by upregulating miR-29c, providing a novel therapeutic target to improve radiotherapy efficiency for patients with NPC.