Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics

Abstract Knowledge of therapeutic targets and early drug candidates is useful for improved drug discovery. In particular, information about target regulators and the patented therapeutic agents facilitates research regarding druggability, systems pharmacology, new trends, molecular landscapes, and the development of drug discovery tools. To complement other databases, we constructed the Therapeutic Target Database (TTD) with expanded information about (i) target-regulating microRNAs and transcription factors, (ii) target-interacting proteins, and (iii) patented agents and their targets (structures and experimental activity values if available), which can be conveniently retrieved and is further enriched with regulatory mechanisms or biochemical classes. We also updated the TTD with the recently released International Classification of Diseases ICD-11 codes and additional sets of successful, clinical trial, and literature-reported targets that emerged since the last update. TTD is accessible at http://bidd.nus. edu.sg/group/ttd/ttd.asp. In case of possible web connectivity issues, two mirror sites of TTD are also constructed (http://db.idrblab.org/ttd/ and http://db.idrblab.net/ttd/).
Extending the context of service: from encounters to ecosystems

Purpose – The purpose of this paper is to extend conceptually the context of service beyond service encounters and servicescapes by applying a service-ecosystem approach to context and experiential view on value. Design/methodology/approach – We develop a conceptual framework of an extended service context that is based on an S-D logic, service-ecosystems view. Findings – The service ecosystem approach proposed here contributes to the advancement of “services” marketing research by extending the context of service in two ways: its emphasis on service as the basis of all exchange allows the consideration of all instances of value-in-use, in-context, to be considered as a service experience; its conceptualization of context broadens the time/place dimensions that conventionally restrain research in service encounters and servicescapes beyond physical, social, symbolic and relational dimensions to consider the multiplicity of institutions across a wider socio-historic space. Research limitations/implications.
Acoustic Streaming Caused by Some Types of Aperiodic Sound. Buildup ofAcoustic Streaming

The analysis of streaming caused by aperiodic sound of different types (switched on at transducer sound or sound determined by initial conditions) is undertaken. The analysis bases on analytical governing equation for streaming Eulerian velocity, which is a result of decomposition of the hydrodynamic equations into acoustic and non-acoustic parts. Its driving force (of acoustic nature) represents a sum of two terms; one is the classic one, which, being averaged over the sound period, coincides with the well-known expression. The second one depends on the periodicity of the sound; at the axis of beam propagation it becomes exactly zero after averaging for the strictly periodic sound but differs from zero for other acoustic waves. Both terms are nonlinear and proportional to the standard attenuation due to shear, bulk viscosities and thermal conductivity. Numerical analysis reveals a qualitative agreement with experimental data. Some theoretical conclusions concerning features of streaming caused by sound determined by initial conditions, are made.
Guiding of positive streamers in nitrogen, argon and N 2 -O 2 mixtures by very low n e laser-induced pre-ionization trails

In previous work we have shown that positive streamers in pure nitrogen can be guided by a laser-induced trail of low electron density. Here we show more detailed results from such measurements. We show the sensitivity of this laser-guiding on pressure p and found that the maximum delay between the laser pulse and voltage pulse for guiding scales with something between $1/p$ and $1/p^{2}$. We also show that when we use a narrower laser beam the laser guiding occurs less frequent and that when we move the laser beam away from the symmetry axis, guiding hardly is observed. Finally we show that laser guiding can also occur in pure argon.
Larvicidal efficacy of ethanolic leaf extracts of four selected local plants from hail region, northern Saudi Arabia, against the dengue fever vector, Aedes aegypti (L.) Under laboratory conditions

This study was conducted to evaluate the efficacy of ethanolic leaf extracts from four selected local plants, Citrullus colocynthis (bitter apple), Artemisia annua (sweet wormwood), Pergularia tomentosa (Fattaka), and Rhanterium epapposum (Arfaj), from Hail region, northern Saudi Arabia, against the larval stages of the Dengue fever vector, Aedes aegypti. Data analyses revealed that ethanolic extracts of both R. epapposum and A. annua were more toxic to the 4th instar larvae of Ae. aegypti compared to the other two plants. The lethal effect of the ethanolic extract of A. annua on the larvae was more effective with time, as the mortality rate increased with spent time, with the highest mortality rate recorded, 95%, was after 72 hours. Moreover, the study revealed that the ethanolic extract of A. annua showed more larvicidal efficacy against Ae. aegypti larvae under lower concentrations compared to the other three
Comparing Explicit and Implicit Learning of Emotional and Non-Emotional Words in Autistic Children

Article history: Received: 10 Mar 2011 Accepted: 24 Aug 2011 Available online: 28 Oct 2012 ZJRMS 2013; 15(2): 64-67 Background: Explicit and implicit memories have different cerebral origins and learning approaches. Defective emotional words processing in children with autism may affect the memory allocated to such words. The aim of this study was comparing two types of (explicit and implicit) memories during processing the two types of (emotional and nonemotional) words in autistic children and their healthy counterparts . Materials and Methods: The present cross sectional study was conducted on 14 autistic children, who had referred to Autism Medical Treatment Center on Tehran, and 14 healthy children in kindergartens and schools across Tehran. For the explicit memory, a list of words was presented to the subjects of our study and they were asked to repeat the words they heard one time immediately and one time with delay. For implicit memory, the subjects were asked to identify the heard words among the presented words. Statistical analysis was performed using two-way analysis of variance . Results: The results showed that the normal children have higher efficiency in explicit and implicit memory than the children with autism (p<0.01). The two-way analysis of memory type and word type showed that the former affects memory significantly (p<0.05) while word type had no significant effect. Conclusion: Autistic children suffer from impaired memory. This defect is higher in implicit memory than in the explicit memory. It is recommended to apply rehabilitation, training, learning approaches and also explicit memory for interventions of autistic children. Copyright © 2013 Zahedan University of Medical Sciences. All rights reserved.
Experimental Study of Synchronous Servo Systems in Electrical and Electronic Engineering Education

In this study firstly synchronous servo system design, function and application of this system are described. Voltage and phase relationships in this 3-line system are investigated. It is made clear why the synchronous servo system is adjusted under certain conditions and what influences play a role. Later we address the torque servo. A “synchronous servo” is defined. The effect of electrical feedback on synchronous is demonstrated and the measures needed for problem-free operation are explained.
Upgrade of the Spacecraft Entry Survival Analysis Module (S ESAM) of the ES A’s Debris Risk Assessment and Mitigation Analysis (DRAMA) Tool

In 2015, ESA’s “ESA Space Debris Mit igation Compliance Verification Guidelines” handbook was released, dealing with the practical aspects of how missions can demonstrate their compliance to, a mong others, the applicable maximum on-ground risk figures. To aid various projects in verifying the requirements, ESA’s Space Debris Office has init iated the upgrade of the DRAMA “Debris Risk Assessment and Mitigation Analysis” software suite. The software tools provided by DRAMA enable an assessment of mitigation strategies for the operational and disposal phases of a mission, including the risk posed due to mission’s space debris and the effectiveness of an end -of-life strategy. Within this framework, DEIMOS Space is responsible for the SESAM (Spacecraft Entry Survival Analysis Module) module of DRAMA, being subcontractor of HTG under an ESA contract. The objective of SESAM is to assess a spacecraft’s survivability by modelling the re-entry of a space system into the Earth’s atmosphere. The destruction of a re-entering object is a complex, highly stochastic mult i-d isciplinary problem. The dynamics of the entry must be coupled with the aerothermodynamics, the thermo -mechanical loads evaluation, and the deformation and fragmentation processes. Together with the detailed modelling of these processes, the object properties in terms of geometry, mass distribution and materials, are also required. Several tools to model the re -entry process have been developed by space agencies and industry. They can be classified in two main categories: object-oriented and spacecraft-oriented. The first is characterized by a finiteelement approach to modelling the objects and processes involved; the second uses simpler models of spacecraft and components, together with trajectory and aerothermodynamics calculat ions to model the demise. The upgraded SESAM fo llows the object oriented approach implementing state-of-the-art features and innovative functionalities. Among others, an interesting and unique feature (not found in literature) is implemented: users can build up spacecrafts as combinations of multip le primit ives (spheres, cones, cylinders and boxes) with two types of relationships between them: “included in” (one primitive is fu lly shielded by another one) or “connected to” (two primitives are both partially exposed to the flowfield). Th is is achieved combin ing fast aerothermodynamic predictions with innovative shading factors computations (fraction of visible primit ives) based on voxels techniques from computer graphics. SESAM is presented in this paper. Results produced are used by the SERAM module of DRAMA to assess the risk on-ground of objects surviving re-entry.
COMPARATIVE COMMUNITY ECOLOGY OF BATS FROM EASTERN PARAGUAY: TAXONOMIC, ECOLOGICAL, AND BIOGEOGRAPHIC PERSPECTIVES

Abstract Based on more than a year and a half of intensive fieldwork, we document the community structure of bats at 2 sites (Reserva Natural del Bosque Mbaracayú and Yaguareté Forests) in eastern Paraguay. Twenty-nine species from 17 genera and 3 families were documented based on more than 7,000 captures. In general, these communities share greatest affinities with either Atlantic rainforest or savanna-grassland sites of South America. Significant differences exist between these communities in terms of structure based on rank-abundance distributions and species composition. Moreover, Yaguareté exhibits significantly more species than does Mbaracayú even after removing the effects of differences due to high-flying insectivores. No significant differences existed between communities regarding other aspects of taxonomic diversity (e.g., evenness, diversity, or dominance of species) or any aspect of functional diversity. A higher degree of habitat heterogeneity at Yaguareté likely underlies these differences in community structure.
L6H9 attenuates LPS‐induced acute lung injury in rats through targeting MD2

Acute lung injury (ALI) is a clinical syndrome characterized by respiratory failure and acute inflammatory response. Myeloid differentiation protein 2 (MD2) has been reported to play a pivotal role in the recognition of LPS and LPS‐mediates inflammatory response. There have been no clinically effective therapeutic drugs for ALI. L6H9, an inhibitor of MD2, showed anti‐inflammatory effects and cardiac protective activity. However, its effect on ALI has not been elucidated. In this study, intratracheal instillation of LPS was employed to induce ALI in rats. L6H9 pretreatment attenuates LPS‐induced pathological variations in lung tissue and pulmonary edema. LPS instillation enhanced lung microvascular permeability, thereby causing inflammatory cells flow into bronchoalveolar lavage fluid (BALF). However, L6H9 inhibited the LPS‐induced upregulation of total protein concentration and the number of inflammatory cells in BALF. In the meantime, macrophages infiltration in lung tissue induced by LPS was also mitigated by L6H9 treatment. Furthermore, L6H9 suppressed LPS‐induced inflammatory cytokines expression in BALF, serum, and lung tissue. It is noteworthy that LPS‐induced MD2/TLR4 complex formation was inhibited by L6H9 in lung tissue. On the whole, these results show that L6H9 can attenuate LPS‐induced ALI in vivo by targeting MD2. Our study provide new candidate for the treatment of ALI.
Characteristics of Low-Level Jets over Northern Taiwan in Mei-Yu Season and Their Relationship to Heavy Rain Events

Abstract The present study investigates the characteristics of low-level jets (LLJs) (≥12.5 m s−1) below 600 hPa over northern Taiwan in the mei-yu season and their relationship to heavy rainfall events (≥50 mm in 24 h) through the use of 12-h sounding data, weather maps at 850 and 700 hPa, and hourly rainfall data at six surface stations during the period of May–June 1985–94. All LLJs are classified based on their height, appearance (single jet or double jet), and movement (migratory and nonmigratory). The frequency, vertical structure, and spatial and temporal distribution of LLJs relative to the onset of heavy precipitation are discussed. Results on the general characteristics of LLJs suggest that they occurred about 15% of the time in northern Taiwan, with a top speed below 40 m s−1. The level of maximum wind appeared mostly between 850 and 700 hPa, with highest frequency at 825–850 hPa. A single jet was observed more often (76%) than a double jet (24%), while in the latter case a barrier jet usually .
Application of ASTER Satellite in Digital Elevation Model Generation: A Review

Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) is an imaging instrument flying on Terra platform. The distinctive specifications of ASTER satellite such as as easy to access, global coverage, cost-effective data and along-track configuration make it as one of the widely used sources of stereo images. Therefore, since the launch of ASTER sensor many studies have been conducted to investigate the accuracy of ASTER-extracted DEM. This study aims to give a review about the characteristics of ASTER instrument as well as the most important studies on the generation and assessment of accuracy of ASTER-extracted DEM.
Extrapolações de soluções obtidas através do método multigrid aplicadas nas equações de Navier-Stokes

Dentre os problemas de Dinâmica dos Fluidos Computacional (Computational Fluid Dynamics, CFD), um que merece destaque e encontrar solucoes satisfatorias para as equacoes de Navier-Stokes, que neste trabalho representam um caso de escoamento laminar bidimensional de um fluido incompressivel em regime transiente. Uma opcao viavel e utilizar metodos computacionais iterativos, dada a dificuldade em obter solucoes analiticas. Neste trabalho optou-se por resolve-las iterativamente atraves do metodo de projecao. Ainda assim, as aproximacoes obtidas durante as iteradas podem convergir muito lentamente consumindo, portanto, um tempo indesejado. Logo, torna-se vantajoso utilizar o metodo multigrid para resolver os sistemas de equacoes originadas do problema discretizado, que e um poderoso acelerador de convergencia e possui baixo custo computacional. E possivel obter um ganho ainda maior aplicando tecnicas de extrapolacoes de solucoes, que podem ser utilizadas apos a realizacao dos ciclos de multigrid. Este trabalho ira analisar a aplicacao de extrapoladores no caso pos-multigrid, levando em conta os seguintes parâmetros: tempo de CPU, pico de memoria de armazenamento, norma adimensionalisada do residuo com base na estimativa inicial, fatores de convergencia e normas de erro de iteracao. Ao final, espera-se poder afirmar qual extrapolador e mais eficaz.
Prevalence and Outcomes of Pediatric In-Hospital Cardiac Arrest Associated With Pulmonary Hypertension*

Supplemental Digital Content is available in the text. Objectives: In adult in-hospital cardiac arrest, pulmonary hypertension is associated with worse outcomes, but pulmonary hypertension–associated in-hospital cardiac arrest has not been well studied in children. The objective of this study was to determine the prevalence of pulmonary hypertension among children with in-hospital cardiac arrest and its impact on outcomes. Design: Retrospective single-center cohort study. Setting: PICU of a quaternary care, academic children’s hospital. Patients: Children (<18 yr old) receiving greater than or equal to 1 minute of cardiopulmonary resuscitation (cardiopulmonary resuscitation) for an index in-hospital cardiac arrest with an echocardiogram in the 48 hours preceding in-hospital cardiac arrest, excluding those with cyanotic congenital heart disease. Interventions: None. Measurements and Main Results: Of 284 in-hospital cardiac arrest subjects, 57 (20%) had evaluable echocardiograms, which were analyzed by a cardiologist blinded to patient characteristics. Pulmonary hypertension was present in 20 of 57 (35%); nine of 20 (45%) had no prior pulmonary hypertension history. Children with pulmonary hypertension had worse right ventricular systolic function, measured by fractional area change (p = 0.005) and right ventricular global longitudinal strain (p = 0.046); more right ventricular dilation (p = 0.010); and better left ventricular systolic function (p = 0.001). Children with pulmonary hypertension were more likely to have abnormal baseline functional status and a history of chronic lung disease or acyanotic congenital heart disease and less likely to have sepsis or acute kidney injury. Children with pulmonary hypertension were more likely to have an initial rhythm of pulseless electrical activity or asystole and were more frequently treated with inhaled nitric oxide (80% vs 32%; p < 0.001) at the time of cardiopulmonary resuscitation. On multivariable analysis, pulmonary hypertension was not associated with event survival (14/20 [70%] vs 24/37 [65%]; adjusted odds ratio, 1.30 [CI95, 0.25–6.69]; p = 0.77) or survival to discharge (8/20 [40%] vs 10/37 [27%]; adjusted odds ratio, 1.17 [CI95, 0.22–6.44]; p = 0.85). Conclusions: Pulmonary hypertension physiology preceding pediatric in-hospital cardiac arrest may be more common than previously described. Among this cohort with a high frequency of inhaled nitric oxide treatment during cardiopulmonary resuscitation, pulmonary hypertension was not associated with survival outcomes.
EphA4/Tie2 crosstalk regulates leptomeningeal collateral remodeling following ischemic stroke.

Leptomeningeal anastomoses or pial collateral vessels play a critical role in cerebral blood flow (CBF) restoration following ischemic stroke. The magnitude of this adaptive response is postulated to be controlled by the endothelium, although the underlying molecular mechanisms remain under investigation. Here we demonstrated that endothelial genetic deletion, using EphA4f/f/Tie2-Cre and EphA4f/f/VeCahderin-CreERT2 mice and vessel painting strategies, implicated EphA4 receptor tyrosine kinase as a major suppressor of pial collateral remodeling, CBF and functional recovery following permanent middle cerebral artery occlusion. Pial collateral remodeling is limited by the cross talk between EphA4-Tie2 signaling in vascular endothelial cells, which is mediated through p-Akt regulation. Furthermore, peptide inhibition of EphA4 resulted in acceleration of the pial arteriogenic response. Our findings demonstrate EphA4 is a negative regulator of Tie2 receptor signaling which limits pial collateral arteriogenesis following cerebrovascular occlusion. Therapeutic targeting of EphA4 and/or Tie2 represents an attractive new strategy for improving collateral function, neural tissue health and functional recovery following ischemic stroke.
Extending the radio spectrum of magnetic chemically peculiar stars to the mm range

Magnetic chemically peculiar (MCP) stars can present radio emission at centimetre wavelengths. The steep decre- ment of the dominant dipolar component of the photospheric magnetic field results in each radio frequency being mainly emitted in a well localised shell of the circumstellar region. To explore the most internal regions of the magnetosphere, observations of a sample of eleven MCP stars known to be radio sources in the 1.4−22.5 GHz range were carried out at 87.7 GHz with the IRAM interferometer. Millimeter emission, with a flux density at about 4× the sensitivity limit of our observations, was detected towards two of the stars: HD 35298 and HD 124224. Combining our mm-observations with previous cm-observations, it appears that MCP stars with a relativelyweak magnetic field present a radio spectrum that increases with frequency up to 22.5 GHz and then decreases towards the mm range. In presence of strong fields, the radio spectrum is always decreasing with frequency. A comparison of the observed cm-mm spectrum of HD 124224 with results of numerical simulations of the gyrosynchrotron emission suggests that circumstellar regions emitting in the mm-range cannot present magnetic fields larger than 1− 2k G.
The frequency of human leukocyte antigen-DRB1 alleles, using sequence-based genotyping in 68 parents-child trios study in Iranian subjects

Background: The human leukocyte antigen-DRB1 (HLA-DRB1) locus is one of the most polymorphic human loci and has a crucial role in the immune system. Assessing the allelic frequencies of HLA-DRB1 locus would be a fundamental factor in defining the origin of populations, relationships with other populations, disease association studies and the constitution of unrelated bone marrow donor registries. In the current study HLA-DRB1 alleles and their frequencies are determined in a family-based study by DNA sequencing-based typing high-resolution (2 field) level of typing. Materials and Methods: Genomic DNA from 3 members of 68 unrelated families (a total of 204 individuals) was extracted. Exon 2 of DRB1 gene was amplified and sequenced and allele assignment was performed using Assign™ SBT v4.7sequence analysis software. Results: We had DRB1*11:04 with frequency of 0.0931, DRB1*03:01 with 0.0882, DRB1*11:01 with 0.0735, DRB1*13:01 with 0.071 and also alleles DRB1*08:03, DRB1*13:42, DRB1*14:04 and DRB1*14:07 with frequency of 0.0024. Conclusion: A total of 34 different alleles were found in the study subjects with DRB1*11:04, DRB1*03:01, DRB1*11:01 being the most frequent alleles respectively. K e y w o r ds: Genotype, HLA-DRB1, Iran, HLA-typing
Experimental realization of an epsilon-near-zero graded-index metalens at terahertz frequencies

Victor Pacheco-Peña, Nader Engheta, Sergei Kuznetsov, Alexandr Gentselev, and Miguel Beruete Antennas Group-TERALAB, Universidad Pública de Navarra, Campus Arrosadía, 31006 Pamplona, Spain Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA Rzhanov Institute of Semiconductor Physics SB RAS, Novosibirsk Branch “TDIAM,” Lavrentiev Avenue 2/1, Novosibirsk 630090, Russian Federation Novosibirsk State University, Pirogova Street 2, 630090 Novosibirsk, Russian Federation Budker Institute of Nuclear Physics SB RAS, Lavrentiev Avenue 11, 630090 Novosibirsk, Russian Federation Institute of Smart Cities, Public University of Navarra, 31006 Pamplona, Spain (Received 10 April 2017; revised manuscript received 8 August 2017; published 29 September 2017)