Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship of cytochrome P-450 activity to Clara cell cytotoxicity. I. Histopathologic comparison of the respiratory tract of mice, rats and hamsters after parenteral administration of naphthalene.

The purpose of this study was to define the sites of cytotoxicity within the respiratory tract (nasal cavity and tracheobronchial airway tree) resulting from administration of naphthalene, an organic chemical whose cytotoxic properties require metabolic activation via the cytochrome P-450 monooxygenase system. Three species were compared: mouse, hamster and rat. Naphthalene was administered in corn oil at these doses: mouse (0-400 mg/kg), hamster (0-800 mg/kg) and rat (0-1600 mg/kg), and the animals were sacrificed 24 hr later. In mice, naphthalene produced Clara cell cytotoxicity at 50 mg/kg. The primary alteration was swelling and vacuolation of Clara cells in terminal bronchioles. At 100 mg/kg, the number of terminal bronchioles with vacuolated Clara cells and the number of Clara cells within terminal bronchioles which showed vacuolation increased. At 200 and 300 mg/kg, almost all of the nonciliated cells lining terminal bronchioles in mice were exfoliated and necrotic. In contrast, there was no apparent effect on Clara cells or ciliated cells of terminal bronchioles in rats treated with up to 1600 mg/kg. At 800 mg/kg, minor alterations in Clara cells in some terminal bronchioles were observed in hamsters. At 300 mg/kg, lobar bronchus and trachea showed swelling 'and vacuolation of nonciliated cells in mice, but no detectable change at 200 mg/kg or below. The trachea and lobar bronchus were unaffected in rats, but showed cytotoxic changes in hamsters. In the nasal cavity of mice, cytotoxicity was observed only in the olfactory epithelium and only in animals treated with 400 mg/kg. There were minimal alterations in the respiratory epithelium. The only epithelial population showing cytotoxicity in the rat was the olfactory epithelium. Complete necrosis was observed at 200 mg/kg and higher. In the hamster there was no discernible alteration in the olfactory epithelium at 100 and 200 mg/kg. At 400 mg/kg, the olfactory epithelium was necrotic. Naphthalene injury to the tracheobronchial epithelium of the mouse is: 1) Clara cell specific; 2) dose-related in the terminal bronchiole; and 3) involves more proximal airways in a dose-dependent fashion. The tracheobronchial epithelium of the rat is refractory to Clara cell injury even at the LD50, but proximal airways are more susceptible than distal airways in the hamster. The nasal cavity shows specific injury in one zone (olfactory epithelium) in a dose and species specific manner. The susceptibility to naphthalene-induced injury in the olfactory epithelium does not correlate with the susceptibility of Clara cells in more distal portions of the respiratory tract. (ABSTRACT TRUNCATED AT 400 WORDS)
A wireless sensor network system using 6LoWPAN

Internet of Things is getting wide-spread attention since it became easily accessible with the low costs nodes. In a typical internet of things application, the data sensed by nodes is usually sent to a central device which collects the information and can act as a gateway towards other networks. In this way the data can be processed in order to command the actuators to perform special tasks. In such networks 6LowPAN together with RPL protocol can be used as an enabler technology. In this study we implemented a 6LowPAN network using Contiki operating system in order to collect information coming from different sensors residing in nodes and stored this information in a database to be accessed by Internet. In our 6LowPAN network nodes send UDP packets to a UDP Server located in a low cost rapid prototyping device.
A DINÂMICA DOS TERMOS DE TROCA E DA BALANÇA COMERCIAL: "CURVA S" NA EUROPA?

Documentam-se as principais caracteristicas ciclicas de variaveis ligadas ao comercio internacional dos paises mais perifericos da Uniao Europeia e comparam-se com as caracteristicas do conjunto da Uniao, apresentando evidencias de que a balanca comercial esta correlacionada negativamente com movimentos passados e presentes dos termos de troca e positivamente com movimentos passados, dando origem a designada S. Aplica-se o modelo de Backus, Kehoe e Kydland (1994) para verificar a sua aproximacao aos dados destes paises e avaliar a sua robustez a outras realidades empiricas. Verificaram-se as principais vantagens do modelo ja identificadas mas a robustez do modelo a diferencas entre paises apenas e verificada numa das variaveis: a balanca comercial.
JACIE – an Authoring Language for Rapid Prototyping Net-Centric, Multimedia and Collaborative Applications

The World Wide Web (WWW) is now accepted as a de facto standard for human–computer interaction and human–human communication, so it is desirable to develop net-centric, multimedia and collaborative applications. In this paper, we present a new scripting language, JACIE, designed to support rapid prototyping and implementation of such applications. The support for the management of multimedia interaction and communication in collaborative applications is highlighted. JACIE facilitates such support through the concepts of channels and a collection of interaction protocols. A template-based programming style is adopted by JACIE, using a single program for both client and server, and platform-independence achieved by employing Java as the target language. All these features characterise a desirable multimedia software engineering tool.
Evaluation of the antidiabetic action of Mangifera indica in mice

The leaves of Mangifera indica were assessed for antidiabetic properties using normoglycaemic, glucose‐induced hyperglycaemia and streptozotocin (STZ) induced diabetic mice. The aqueous extract produced a reduction of blood glucose level in normoglycaemic and glucose‐induced hyperglycaemia, but did not have any effect on streptozotocin‐induced diabetic mice. The hypoglycaemic effect of the aqueous extract was compared with that of an oral dose of chlorpropamide under the same conditions. The results of this study indicate that the aqueous extract of the leaves of Mangifera indica possess hypoglycaemic activity. Copyright © 2001 John Wiley & Sons, Ltd.
The Cycle of Violence

The U.S. Department of Justice published an updated study comparing the arrest records of children who were abused and/or neglected to those who had not had those developmental disadvantages. The entire report is available at http://www.ojp. usdoj.gov/nij. Key findings were: Being abused or neglected resulted in the increase likelihood of a juvenile arrest by 59% and as an adult by 28% and for a violent crime by 30%. Maltreated children committed twice as many offenses as nonabused children and were also younger when first arrested. Neglect and physical abuse was more highly correlated with violent crime arrests than sexual abuse. Black abused and neglected children had higher rates of violent arrests than black children who were not subject to maltreatment. This finding was not supported among white children. Finally, an out-of-home placement was not significantly related to the number of arrests among those children removed from their homes due only to abuse and neglect. The suggested recommendations based on these findings were: Early intervention by mental health, school and law enforcement is imperative if later juvenile and adult arrests for violent criminal behavior are to be reduced. It is also important to recognize that neglect alone carries a high risk in that today’s victims may become the violent offenders in the future. Finally, removing the child from a dysfunctional home environment did not increase future arrest risk despite the commonly held assumption that the child will be better off with
Los mamíferos del Mioceno y Plioceno de Espinar (Cusco): antecedentes y proyecto

En noviembre de 2002, durante la obra de excavacion de un reservorio de agua para irrigacion, trabajadores de la Villa Accocunca (Alto Pichigua) se toparon con los restos fosilizados de un gran «armadillo», a casi tres metros de profundidad. Durante el proceso de colecta, realizado por uno de los autores (JG), colaboradores del INC-CUS y pobladores locales, solo fue posible apreciar el caparazon, los anillos y el tubo caudal. Sin embargo, la limpieza y conservacion de los huesos en el laborat.
Transcriptional processing of G4 DNA

Genomic DNA sequences with the ability to assume non‐B form secondary structures have been recently shown to be particularly susceptible to genetic instability, an early contributing factor in human disease and cancer development. Transcription appears to play a central role in formation of these structures and in promoting instability at these sites. The subpathway of nucleotide excision DNA repair, transcription‐coupled DNA repair (TCR), removes transcription‐arresting damage from the transcribed strands of expressed genes, but little is known about how non‐canonical DNA structures are processed when encountered by the transcription machinery. If such structures arrest transcription, they may elicit “gratuitous” TCR in which the resulting reiterative and futile repair replication might generate a significant level of mutagenesis in a frequently transcribed gene because of faulty processing in the area of transcription arrest. Here we will describe our current understanding of how TCR may be elicited at non‐B DNA structures and summarize recent literature describing the behavior of RNA polymerases when encountering non‐canonical DNA structures, with particular emphasis on quadruplex DNA. © 2009 Wiley‐Liss, Inc.
EXISTENCE AND UNIQUENESS FOR ONE-PHASE STEFAN PROBLEMS OF NON-CLASSICAL HEAT EQUATIONS WITH TEMPERATURE BOUNDARY CONDITION AT A FIXED FACE

We prove the existence and uniqueness, local in time, of a solution for a one-phase Stefan problem of a non-classical heat equation for a semi- infinite material with temperature boundary condition at the fixed face. We use the Friedman-Rubinstein integral representation method and the Banach contraction theorem in order to solve an equivalent system of two Volterra integral equations.
Parcours, d eplacements et actions face au rayon : mieux comprendre le comportement physique du consommateur en magasin pour mieux comprendre ses achats

Si l’etude du comportement du consommateur en magasin prend une importance croissante dans la litterature en marketing, la plupart des recherches n’observent pas reellement ce comportement. Le plus souvent, il est mesure par des questionnaires, c’est-a-dire comportements declares pouvant etre tres differents du comportement reel. Pourtant, les achats du consommateur, pour la plupart decides en magasin, dependent directement de son comportement physique en magasin, c’est-a-dire de son parcours a travers le point de vente, des rayons visites et evites, des produits devant lesquels il passe et des actions qu’il effectue quand, arrete devant un rayon, il prend, examine, essaie et finalement repose ou choisit un produit plutot qu’un autre. L’idee principale de cette these est donc d’etudier le comportement physique du consommateur en magasin. Cette these est composee de deux etudes. La premiere etude a pour but de mieux comprendre de qu’est le comportement physique en magasin : en avoir une vue synthetique et intelligible en identifiant les principales dimensions qui le composent et ses relations avec les achats. La deuxieme etude a pour objectif d’utiliser l’information contenue dans ce comportement physique pour ameliorer un modele probabiliste d’analyse des achats : l’analyse du panier du consommateur. Chacune de ces recherches permet d’etudier le comportement sous un angle different. L’ensemble tente ainsi d’apporter une connaissance nouvelle sur le comportement du consommateur en magasin. Pour atteindre nos objectifs de recherche, nous avons developpe un nouvel outil de recueil de donnees permettant d’observer de maniere non intrusive et de saisir et chronometrer les actions precises des consommateurs tout au long du parcours en magasin.
Vocal performance influences female response to male bird song: an experimental test

Female songbirds are thought to assess males based on aspects of song, such as repertoire size or amount of singing, that could potentially provide information about male quality. A relatively unexplored aspect of song that also might serve as an assessment signal is a male's ability to perform physically challenging songs. Trilled songs, such as those produced by swamp sparrows (Melospiza georgiana), present males with a performance challenge because trills require rapid and precise coordination of vocal tract movements, resulting in a trade-off between trill rate and frequency bandwidth. This trade-off defines a constraint on song production observed as a triangular distribution in acoustic space of trill rate by frequency bandwidth, with an upper boundary that represents a performance limit. Given this background on song production constraints, we are able to identify a priori which songs are performed with a higher degree of proficiency and, thus, which songs should be more attractive to females. We determined the performance limit for a population of swamp sparrows and measured how well individual males performed songs relative to this limit ("vocal performance"). We then compared female solicitation responses to high-performance versus low-performance versions of the same song type produced by different males. Females displayed significantly more to high-performance songs than to low-performance songs, supporting the hypothesis that females use vocal performance to assess males. Copyright 2004.
Transcatheter closure of atrial septal defects in adults > or =40 years of age: immediate and follow-up results.

BACKGROUND Controversy still exists regarding closure of atrial septal defects (ASDs) in patients >40 years of age who are largely asymptomatic or do not have large shunts (LS). If left unrepaired, the majority of patients will experience symptoms and will have a shorter life span compared to patients who undergo repair. This study presents the outcomes of closure of ASDs in adults >40 years using the Amplatzer septal occluder. METHODS A total of 113 patients (79F/34M) with a mean age of 57.9 years (SD 11.9) who had indications for closure (right ventricular [RV] enlargement by echocardiograpy, clinically symptomatic) underwent an attempt of transcatheter closure. The mean size of ASD as measured by transesophageal echocardiography (TEE) (30 patients) or intracardiac echocardiography (83 patients) was 17.2 mm (SD 7.3) with mean Qp:Qs of 2.2:1 (SD 1.1). Follow-up at 24 hours, 6 month, and yearly thereafter included physical examination, TEE, and/or transthoracic echocardiography; furthermore, chart review (n = 112) as well as telephone interviews (n = 56) were conducted to determine clinical symptomatic status. RESULTS The procedure was successful in 112 patients and 1 patient failed due to the presence of a large defect (44 mm). One hundred four patients had a single device implanted, 7 had two, and 1 had three. Following the procedure, 96 patients had immediate complete closure (CC), 3 had trivial shunt (TS), 11 had small shunt (SS), and 2 had moderate shunt (MS). At 24 hours postprocedure, 100 patients had CC, 7 had TS, 3 had SS, 1 had MS, and 1 had LS. Four patients had complications: one had device migration within 24 hours, two had atrial arrhythmias (supraventricular tachycardia, atrial tachycardia), and one had large hematoma. At 6 months postprocedure, 100 patients had CC, 6 had TS, 5 had SS, and 1 had MS. At 6-month follow-up, the right ventricle end-diastolic dimension decreased from 35.3 mm (SD 7.6) preprocedure to 23.8 mm (SD 6.6) (P < 0.001) and the majority of patients reported improvement in their symptoms. CONCLUSIONS ASD closure is safe and effective in patients over 40 years of age with minimal complications. The procedure resulted in a decrease in the RV size that was accompanied by improvement in clinical symptoms. Our findings suggest that device closure of ASDs in adult patients >40 years of age should be the first option of management.
Classifying weather time series using featurebased approach

Classification of weather time series is beneficial for weather forecasting problem. The classification can assist in identifying weather patterns for certain periods. In addition, extracting patterns from weather time series provides useful insights about the weather conditions to the domain experts. In this paper, we present the classification of weather time series using feature based approach that extracts feature vectors from the time series and performs the classification based on local and global features. The experimental results show that feature-based method with random forest performs well with more number of subsequences and may achieve comparable results with other methods.
Flow cytometric analysis of chimerism in the rat tolerant to a renal allograft.

BACKGROUND Chimerism, produced by the two-way migration of cells between graft and host, is a proposed mechanism by which tolerance occurs. The appearance of donor/recipient chimeras in tolerant ACI to Lewis rat heterotopic renal transplants was assessed in peripheral blood leukocytes using flow cytometry after staining with monoclonal antibodies. MATERIALS AND METHODS ACI and Lewis rats were used as donor and recipient, respectively, after Rapamycin and Cyclosporin immunosuppression with or without donor blood or bone marrow transfusion. ACI and Lewis animals were also used for isograft and single-kidney controls. Animals were sacrificed at various time points after initial operation. Flow cytometry was performed on isolated peripheral blood leukocytes at sacrifice. Histologic and functional data were also obtained. The monoclonal antibody panel included RT1(a) (ACI, MHC I) combined with CD2, CD4, CD8, CD16, and CD25 or RT1(a,c) (bone marrow chimeras). RESULTS RT1(a)+, CD8+ cells were transiently present in the peripheral blood leukocytes of Lewis recipients with the exception of allogeneic bone marrow recipients. No significant number of RT1(a)+, CD16+ ("dendritic" cell-line) chimeras was seen. Veto cells (RT1(a,c)+) were transiently present in the bone marrow recipients, but they did not lead to improved outcome. Furthermore, no correlation was made between histologic tolerance and any of these donor-derived cells. CONCLUSION Donor/recipient chimerism, and the veto cell phenomenon are not operational tolerance mechanisms in this stringent model of ACI to Lewis rat renal transplantation.
Perfil audiológico em policiais militares do Estado de São Paulo

INTRODUCAO: Os policiais militares constituem uma populacao exposta a ruido de impacto devido aos treinamentoscom armas de fogo. OBJETIVO: Pesquisar o perfil audiologico em policiais militares do estado de Sao Paulo, e correlacionar a idade e o tempo de exposicao com os achados audiologicos. METODO: Neste estudo de serie de casos, transversal, foi realizada avaliacao audiologica em 200 policiais militares sendo 169 (84,5%) do genero masculino e 31 (15,5%) do feminino, com idades entre 25 e 45 anos (media de 38,83±5,05), com media de tempo de servico de 16,80±6,27 anos. RESULTADOS: As principais queixas apontadas foram: zumbido (n= 52 / 26%), disacusia (n=36 / 18%), plenitude auricular (n=24 / 12%) e autofonia (n=24 / 12%). Na imitanciometria foram encontradas 100% de curvas tipo A (JERGER, 1970), e houve presenca de recrutamento em 20 (10%) casos. Segundo os resultados a audiometria tonal, os dados obtidos demonstraram que 54 (27%) orelhas direita e 56 (28%) orelhas esquerda apresentaram perda auditiva. Os graus de perda com maior ocorrencia foram 1 e 2 (MERLUZZI et al., 1979), com 85 (42,5%) casos. Houve correlacao significativa entre a idade e o tempo de exposicao com a piora dos limiares audiometricos em ambas as orelhas. CONCLUSAO: A partir da analise dos dados audiologicos foi possivel verificar que os policiais militares sao uma >populacao que apresenta risco para desenvolver a perda auditiva. Sendo assim, vemos a necessidade e implementacao de programa de conservacao auditiva para os policiais militares.
A SVD based controller reduction method

In this paper an efficient controller reduction method which guarantees closed loop stability is described. The reduced controller is obtained by solving a generalized controllability Grammian type Lyapunov inequality. This Lyapunov inequality based reduced controller search can be formulated as a generalized minimum rank matrix approximation problem to which an efficient singular value decomposition based solution procedure is available. This paper contains theoretical and numerical results on the merit of the proposed reduction method.
La mise à jour du Modèle Multimodal Transfrontalier du Grand Genève. Présentation des opérations de mise à jour réalisées au sein de la Direction Générale de la Mobilité de l'Etat de Genève

Ce memoire presente la mise a jour du Modele Multimodal Transfrontalier du Grand Geneve effectuee entre avril et septembre 2012 par la Direction Generale de la Mobilite et le bureau d'etudes Citec. L'historique, le mode de gestion et l'architecture du modele y sont decrits. Nous nous attachons a analyser le role de la frontiere franco-suisse dans la mobilite au sein de l'agglomeration du Grand Geneve et son impact en termes de modelisation. Il apparait que la marcosimulation classique a des difficultes a reproduire la dynamique propre aux flux transfrontaliers. Nous presentons egalement les operations de mise a jour du modele d'offre realisees en interne par la Direction Generale de la Mobilite. Pour caler les temps de parcours en transports individuels et construire les courbes debit-vitesse nous avons utilise des donnees agregees de vitesses des vehicules des particuliers sur le reseau routier issues d'appareils d'aide a la navigation par GPS.
L'impact des pyramides de contrôle au Canada sur les entreprises dites indépendantes

Ce memoire de recherche vise a voir si les entreprises dites independantes, qui possedent un membre du conseil d'administration appartenant a une grosse compagnie pyramidale, ont une meilleure performance que celles qui sont completement independantes, en dehors de toute structure pyramidale. Pour cela, nous avons construit une base de donnees canadienne, effectue des comparaisons croisees et, a l'aide du logiciel SPSS, nous avons utilise et teste de differentes facons les indicateurs de performance (ROA, ROE, Q de Tobin) et de couts d'agence (SGASALES) en effectuant des regressions et des t-tests de Student. Nous avons obtenu les resultats principaux suivants: le ROA et le ROE augmentent de maniere significative et les couts d'agence (SGASALES) sont excessivement moins eleves lorsque la variable pyr= 1 en comparaison avec pyr=0, c'est-a-dire quand les entreprises independantes font en fait partie d'une certaine maniere des structures pyramidales en comparaison avec les entreprises totalement independantes. Il va sans dire que les ecarts trouves sont assez importants.
Universal design: towards universal access in the information society

This workshop aims to advance an understanding of the concepts and principles of universal design and extrapolate on their relevance to Information Society Technologies. Specifically, the workshop will seek to review methods and techniques currently in use, ongoing work and future research issues, and establish the foundations of a conceptual frame of reference for applying universal design into Information Society Technologies in general, and HCI in particular.