Miracle-dz/UniFAR-FTUs huggingface dataset:
Blood volume and haemoglobin concentration at altitudes above 18,000 ft. (5500 m)

The haemoglobin levels of climbers ascending to great altitudes in the Himalaya or the Karakoram do not as a rule reach the high values (22.9 + 2*6 g/100 ml.) reported on South American miners living at 17,500 ft. (5340 m; Dill, Talbott & Consolazio, 1937). Observations on sixty subjects on eight mountaineering expeditions (including the present one) showed a final mean haemoglobin value of 20-19 g/100 ml. (Table 1). On Mount Cho Oyu (1952) and Mount Everest (1953) mean haemoglobin values were similar to each other, although the time spent at high altitude was longer and the altitudes greater on the later expedition. Pace, Meyer & Vaughan (1956) found that haemoglobin values reached a steady level in about 50 days, and the same was true on Mount Cho Oyu (1952; Pugh, unpublished). These results (as well as the small variation between expeditions) suggest that 20 + 1-5 g/100 ml. is a physiological limit for plainsmen living at heights above 18,000 ft. (5500 m). However, rather large variations have been observed occasionally in small groups after final assaults on high peaks. For example, Luft (1941) reported a mean value of 24 g/100 ml. on four subjects, while Somervell (1925) and Brendel (1956) noted falls in haemoglobin. The Himalayan Scientific and Mountaineering expedition of 1960/61 made a further contribution to the subject by measuring blood volume and haemotocrit changes as well as haemoglobin. This expedition spent 81 months above 15,000 ft. (4570 m), including 5 months at 19,000 ft. (5800 m), and was therefore in the field much longer than previous expeditions, most of which have lasted 3 months and none longer than 6 months.
A distributed real time eye-gaze tracking system

This paper describes a real-time eye-gaze tracking system that bases its accuracy in a very precise estimation of the user's pupil centre. The system consists of two cameras, four illuminators and a low cost cluster of four PC's interconnected by a gigabit network. One of the cameras is mounted on a pan-tilt unit in order to perform the tracking of the person's eye. The second camera is fixed, gets a general view of the scene and it is used for finding the eye when the first camera loses it. Since high precision is needed for the determination of the point of gaze, high resolution images must be processed, For fulfilling time restrictions, image processing must be parallelised.
Design and trial of a new ambulance-to-emergency department handover protocol: ‘IMIST-AMBO’

Background Information communicated by ambulance paramedics to Emergency Department (ED) staff during handover of patients has been found to be inconsistent and incomplete, and yet has major implications for patients' subsequent hospital treatment and trajectory of care. Aim The study's aims were to: (1) identify the existing structure of paramedic-to-emergency staff handovers by video recording and analysing them; (2) involve practitioners in reflecting on practice using the footage; (3) combine those reflections with formal analyses of these filmed handovers to design a handover protocol; (4) trial-run the protocol; and (5) assess the protocol's enactment. Method The study was a ‘video-reflexive ethnography’ involving: structured analysis of videoed handovers (informed by ED clinicians' and ambulance paramedics' comments); ED clinicians and ambulance paramedics viewing their own practices; and rapid at-work training and feedback for paramedics. A five-question pre- and post-survey measured ED triage nurses' perceptions of the new protocol's impact. In total, 137 pre- and post-handovers were filmed involving 291 staff, and 368 staff were educated in the use of the new protocol. Results There was agreement that Identification of the patient, Mechanism/medical complaint, Injuries/information relative to the complaint, Signs, vitals and GCS, Treatment and trends/response to treatment, Allergies, Medications, Background history and Other (social) information (IMIST-AMBO) was the preferred protocol for non-trauma and trauma handovers. Uptake of IMIST-AMBO showed improvements: a greater volume of information per handover that was more consistently ordered; fewer questions from ED staff; a reduction in handover duration; and fewer repetitions by both paramedics and ED clinicians that may suggest improved recipient comprehension and retention. Conclusion IMIST-AMBO shows promise for improving the ambulance-ED handover communication interface. Involving paramedics and ED clinicians in its development enhanced the resulting protocol, strengthened ED clinicians' and ambulance paramedics' sense of ownership over the protocol and bolstered their peers' willingness to adopt it.
New CEO Openness to Change and Strategic Persistence: The Moderating Role of Industry Characteristics

Drawing on the upper echelons, managerial discretion and strategic contingency perspectives we examine the relationships between newly chosen CEOs' openness to change and firm strategic persistence in the post-succession phase. This study is different from prior studies on the consequences of CEO succession in that it focuses on specific characteristics of the new CEO (that reflect his/her knowledge-base and cognitive orientations) and the industry context rather than purely on the event of succession. Based on a sample of 132 successions in 118 firms in the US manufacturing sector, and after controlling for industry concentration, board power, firm size and pre-succession performance, we find a negative relationship between CEOs' openness to change and post-succession strategic persistence. Interestingly, our findings indicate that this relationship is moderated by industry characteristics in that the negative association between CEO openness to change and strategic persistence is significant in high-discretion but not in low-discretion industries. Contributions of the paper to the CEO succession and strategic change literatures along with the managerial implications of our findings are discussed in the concluding section of the paper.
Optimization and early-warning in DSL access networks based on simulation

Network providers operate large DSL-based access networks to offer customers Broadband Internet. These networks are observed and managed by Performance Management Systems (PMS), that capture the actual situation to support network administration. In this regard, the administrator can cope with incidents such as link failures or congestion. We present an application for optimization and forecast of traffic distributions in DSL networks as an addition to an existing PMS. This application makes heavy use of simulation. In this way, we give a description of traffic models based on real network performance data reflecting: (I) individual subscribers and (II) an aggregated model for multiple subscribers. Then, we introduce the overall simulation approach based on the Network Security Simulator NeSSi2. The evaluation takes place by a use case for simulation-based verification of applied optimization strategies and a use case for continuous forecast to predict upcoming link congestion.
Red neuronal autorregresiva no lineal con entradas exógenas para la predicción del electroencefalograma fetal

Este articulo describe un algoritmo simple y robusto para la simulacion de senales biomedica usando una red neuronal autorregresiva no lineal con entradas exogenas (NARX- nonlinear autorregresive network with exogenous inputs). La NARX puede ajustarse para sistemas dinamicos cuya salida depende tanto de la entrada recibida como del estado en que se encuentre el sistema. Por lo que es especialmente adecuada para la estimacion de los componentes cuasi-periodico de las senales fisiologicas, tales como el Electroencefalograma (ECG). La validez y rendimiento del metodo descrito se confirman a traves de experimentos sobre datos reales obtenidos de la base de datos de acceso publico PhysioNet.
Understanding the Disparities of Citizen Health Preparedness - Can Providers Help Close the Gaps?

1Health security is a state in which a community and its people are prepared for, protected from, and resilient in the face of incidents with health consequences. 2 The two are intrinsically linked. Disparities in health outcomes are commonly explored with respect to traditional public health prevention and promotion programs and result in a more insightful understanding of the burden of infant mortality rates, complications from diabetes, and hospitalization rates. 3 More uncommon, however, is the application of such analysis to determine potential outcomes and indicators of public health preparedness. Such application may further define a given subset of the community’s vulnerability to an emergency or largescale disaster. With a renewed focus in Rhode Island on achieving health equity and reducing the inequities caused by social and environmental determinants of health, dialogue between the public health and healthcare sectors about addressing the gaps in health preparedness can be catalyzed. Access to adequate food, water, shelter, clothing, and proper medical care are often noted by the world community as basic human rights (i.e., decent standard of living) and therefore, also as elements needed to ensure health equity. 4
Transcriptional Activities of the Zinc Finger Protein Zac Are Differentially Controlled by DNA Binding

ABSTRACT Zac encodes a zinc finger protein that promotes apoptosis and cell cycle arrest and is maternally imprinted. Here, we show that Zac contains transactivation and repressor activities and that these transcriptional activities are differentially controlled by DNA binding. Zac transactivation mapped to two distinct domains. One of these contained multiple repeats of the peptide PLE, which behaved as an autonomous activation unit. More importantly, we identified two related high-affinity DNA-binding sites which were differentially bound by seven Zac C2H2 zinc fingers. Zac bound as a monomer through zinc fingers 6 and 7 to the palindromic DNA element to confer transactivation. In contrast, binding as a monomer to one half-site of the repeat element turned Zac into a repressor. Conversely, Zac dimerization at properly spaced direct and reverse repeat elements enabled transactivation, which strictly correlated with DNA-dependent and -independent contacts of key residues within the recognition helix of zinc finger 7. The later ones support specific functional connections between Zac DNA binding and transcriptional-regulatory surfaces. Both classes of DNA elements were identified in a new Zac target gene and confirmed that the zinc fingers communicate with the transactivation function. Together, our data demonstrate a role for Zac as a transcription factor in addition to its role as coactivator for nuclear receptors and p53.
Dicer regulates non-homologous end joining and is associated with chemosensitivity in colon cancer patients

DNA double-strand break (DSB) repair is an important mechanism underlying chemotherapy resistance in human cancers. Dicer participates in DSB repair by facilitating homologous recombination. However, whether Dicer is involved in non-homologous end joining (NHEJ) remains unknown. Here, we addressed whether Dicer regulates NHEJ and chemosensitivity in colon cancer cells. Using our recently developed NHEJ assay, we found that DSB introduction by I-SceI cleavage leads to Dicer upregulation. Dicer knockdown increased SIRT7 binding and decreased the level of H3K18Ac (acetylated lysine 18 of histone H3) at DSB sites, thereby repressing the recruitment of NHEJ factors to DSB sites and inhibiting NHEJ. Dicer overexpression reduced SIRT7 binding and increased the level of H3K18Ac at DSB sites, promoting the recruitment of NHEJ factors to DSBs and moderately enhancing NHEJ. Dicer knockdown and overexpression increased and decreased, respectively, the chemosensitivity of colon cancer cells. Dicer protein expression in colon cancer tissues of patients was directly correlated with chemoresistance. Our findings revealed a function of Dicer in NHEJ-mediated DSB repair and the association of Dicer expression with chemoresistance in colon cancer patients.
Trapping Electron-Assisted Magnetic Recording Enhancement via Dielectric Underlayer Media

Trapping electron-assisted magnetic recording (TEAMR) has been recently proposed as a method of lowering the magnetic anisotropy of magnetic data storage media during write cycles. In this paper, we studied theoretically the TEAMR feasibility when an additional dielectric nano-underlayer is incorporated within the recording medium. We report a comparative study between a standard TEAMR data storage system and a dielectric underlayer TEAMR system. Our results indicate a substantial improvement in the electron trapping mechanism when a dielectric underlayer is used. A direct consequence of the proposed system is the effective reduction of the local magnetic coercive field when using this modified TEAMR design, which opens up the possibility of future developments based on TEAMR technology.
Praxiserprobte Muster und Landkarten zur serviceorientierten Integration von Standardsoftware

Eine Arbeitsgruppe des SOA Innovation Lab e.V. (www.soa-lab.de) analysiert derzeit, welche Erfahrungen die verschiedenen Mitgliedsunternehmen mit der serviceorientierten Integration von Standardsoftware gemacht haben. Die Ergebnisse werden auf der Basis eines Reifegradmodells für serviceorientierte Architekturen ausgewertet und für alle Mitglieder aufbereitet. Als Teilaspekt wurde insbesondere die Frage untersucht, inwiefern sich die serviceorientierte Integration von Standardsoftware von den in vielen Unternehmen etablierten Integrationslösungen unterscheidet und welche Lösungsmuster sich in der Praxis als hilfreich erwiesen haben. 1 Einleitung und Motivation Standardsoftwareprodukte koexistieren mit individuell entwickelten Anwendungen in der IT-Anwendungslandschaft und sind mit diesen auf vielfältige Weise verzahnt. Da beide Arten von Software jedoch unterschiedlichen Treibern folgen, entsteht ein Spannungsfeld: Individualsoftware wird in der Regel über Modularisierung und Serviceorientierung hinsichtlich Agilität, Erweiterbarkeit und Integrierbarkeit optimiert. Standardsoftwareprodukte im Enterprise-Umfeld hingegen sind hauptsächlich auf niedrige Total Cost of Ownership (TCO) und hohen Durchsatz ausgerichtet; Modularisierung und Serviceorientierung waren in der Vergangenheit nicht die entscheidenden Erfolgsfaktoren. Für so genannte End-to-End-Geschäftsprozesse ist die Verzahnung der beteiligten Individualund Standardsoftwareprodukte jedoch inzwischen ein entscheidender Erfolgsfaktor geworden. Von einer serviceorientierten Integration verspricht man sich das notwendige Maß an Agilität und Flexibilität, um sich am Markt von seinen Mitbewerbern differenzieren zu können ([En+08], [Kr+05], [Ke07]). Die Arbeitsgruppe entwickelt einen Werkzeugkasten, der Mitgliedsunternehmen dabei helfen soll, maßgeschneiderte Lösungen für diese Problemstellung zu finden. Zum Werkzeugkasten gehören eine Liste von bewährten Integrationsmustern (Kapitel 2) und eine Landkarte
Apolipoprotein(A) And Atherogenesis

&NA; Lipoprotein(a) (Lp(a)) consists of a unique apolipoprotein, apolipoprotein(a), (apo(a)) linked by a disulphide bridge to apolipoprotein B of low density lipoprotein (LDL). Apo(a) is homologous with plasminogen and exhibits genetic polymorphism with the commoner phenotypes due to larger forms being associated with lower plasma levels and the less common phenotypes associated with smaller forms and higher plasma levels. The later are more common in patients with macrovascular disease. In a study of 6448 patients with established coronary heart disease we found that 43% had apo(a) levels above 300 units/litre and 10% had levels above 1000 units/litre and a geometric mean of 201 units/litre in contrast to 140 normal controls in whom 25% exceeded 300 units/litre, 1% exceeded 1000 units/litre and the geometric mean was 107 units/litre. Amongst patients with cholesterol levels <5.5 mmol/L undergoing coronary artery surgery were patients with low HDL levels and raised apo(a) levels who would not be identified in screening focusing primarily on total cholesterol. In patients with both insulin dependent and non insulin dependent diabetes mellitus those with microalbuminuria or albuminuria (known to be at high risk for macrovascular disease) had apo(a) levels comparable to non diabetic patients with coronary artery disease while diabetic patients without microalbuminuria had normal levels of apo(a). It is likely that apo(a) has a role in the accelerated macrovascular disease in diabetic patients with renal disease.
Clarification of social support.

PURPOSE To clarify the concept of social support. DESIGN Template Verification and Expansion Model. METHODS Meta-synthesis strategies. FINDINGS Social support is composed of emotional and instrumental support. It is an advocative interpersonal process characterized by reciprocal exchange of information, it is context specific, and it results in improved mental health. Antecedents of emotional and instrumental support include a perceived need plus a social network and climate that are conducive to the exchange of social support. CONCLUSIONS In keeping with the nonprofessional nature of social support, nurses are advised to encourage patients to use and enhance personal support networks. For the same reason, nurses should reconsider investigating social support as a nursing intervention. Expanded efforts are needed to differentiate social support from concepts such as caring.
Improving the robustness of image-based tracking to control 3D robot motions

This paper reports new techniques to render real-time image-based tracking methods more robust to enable the control of robots in an arbitrary 3D indoor environment. The methods enable robust feature tracking by integrating several cues within tracking windows. Integration is achieved using EPIC, a method of edge-projected integration of cues at field rate using a common Pentium PC. The thorough analysis of the control loop indicates this need to operate at field rate to obtain optimal dynamic performance. The demonstration verifies this and shows the application of following in 6D a grey part over grey metal background using common room lighting.
Cyber Deception for Computer and Network Security: Survey and Challenges

Cyber deception has recently received increasing attentions as a promising mechanism for proactive cyber defense. Cyber deception strategies aim at injecting intentionally falsified information to sabotage the early stage of attack reconnaissance and planning in order to render the final attack action harmless or ineffective. Motivated by recent advances in cyber deception research, we in this paper provide a formal view of cyber deception, and review high-level deception schemes and actions. We also summarize and classify recent research results of cyber defense techniques built upon the concept of cyber deception, including game-theoretic modeling at the strategic level, network-level deception, in-host-system deception and cryptography based deception. Finally, we lay out and discuss in detail the research challenges towards developing full-fledged cyber deception frameworks and mechanisms.
A service-oriented monitoring registry

Web services are software modules that expose their functionality over the Internet via well-defined interfaces. Although Web services are promising technologies in that they facilitate application-to-application communication over the Internet, they still rely on traditional distributed computing communication models such as the remote procedure call, in which a Web service requestor needs to have complete knowledge of a Web service provider interface. If a Web service requestor did not use the latest version of a Web service provider interface to generate a proxy service, then static binding to the Web service provider's services fails. In this paper, we provide functional requirements for a Service-Oriented Monitoring Registry (SOMR) that provides notification to service requestors when a version of an interface changes or a service becomes disabled. In order to present a more complete picture of SOMR we include four architectural views covering (i) the over-all system, (ii) its four tiers and their interconnection, (iii) details of the service tier and (iv) its deployment onto executable environments. SOMR provides public Web service registries that can be used by Web service providers, developers, and consumers to register their profiles so that whenever any change happens to Web service interfaces they are notified about these changes and can respond accordingly. In contrast with current static solutions, the proposed system provide a significant step toward achieving solutions that are consistent with the dynamic nature and evolution of Web services.
DETERMINATION OF VOLATILE ORGANIC COMPOUNDS IN THE BUILDING OF PRINTING COMPANY

The man spends at work 40 hours per week in average. Therefore, the working environment should also satisfy requirements to indoor environmental quality. However, it is difficult for some workplaces. Measurements were carried out in the building of printing company during normal operation hours. Strong odour always prevails in this building because of the presence of printing inks and other chemicals. This odour can cause discomfort and thus reduce performance of workers. It is also known that odour can be caused by volatile organic compounds (VOCs). These compounds are usual gaseous pollutants in indoor air and they are known to have negative effect on human health. Problem with VOCs is that they may be released from many different sources in indoors or outdoors. Concentrations of total volatile organic compound (TVOC), which represent sum of all VOCs in the indoor air, were measured with photoionization detector with UV lamp. Simultaneously, relative humidity and air temperature was determined with data logger. The results were compared with recommended values for indoor air. In addition, questionnaire survey was carried out in order to determine the subjective perception of the indoor environmental quality by employees. The aim of this study was to determine actual information about levels of VOCs in buildings in eastern Slovakia. The results showed that parameters of air temperature and relative humidity were in accordance with recommended values for work environment in heating season. Despite this fact, employees perceived moderate heat during their work. On the other hand, TVOC concentrations reached relatively high levels (2596.5 μg/m) and significantly fluctuated with time. The most occurring “sick building syndrome” (SBS) symptoms were fatigue, headache, dizziness, memory impairment and difficulty in concentration between employees. Employees rated their working environment as more acceptable than unacceptable and quite tolerable despite their complaints in questionnaires.