Miracle-dz/UniFAR-FTUs huggingface dataset:
Abdominoplasty, Liposuction of the Flanks, and Obesity: Analyzing Risk Factors for Seroma Formation

Background: The purpose of this study was to determine whether seroma formation following abdominoplasty is associated with simultaneous liposuction of the flanks and to stratify the risk of developing seromas according to body mass index. Methods: A retrospective review was conducted of 118 consecutive patients who underwent abdominoplasty with or without flank liposuction from 1992 to 2002. Patients in the abdominoplasty with flank liposuction category were further substratified according to the use of conventional versus ultrasound-assisted liposuction. Data regarding patient age, body mass index, and the occurrence of seromas were collected and analyzed. Results: Fifteen of the 39 patients who underwent abdominoplasty alone (38 percent) developed seromas. This was comparable to the 23 of 79 patients (29 percent) who developed seromas after abdominoplasty combined with flank liposuction (p = not significant). Eight of 19 patients (42 percent) who had liposuction performed with ultrasound assistance developed seromas, compared with 15 of 60 patients (25 percent) who underwent conventional liposuction without ultrasound (p = not significant). When stratified according to body mass index, overweight or obese patients were more likely to develop seromas than patients of normal weight, whether liposuction was performed in the same setting or not [seromas in seven of 37 (19 percent) of normal weight patients versus 31 of 81 (38 percent) of overweight and obese patients, p < 0.05]. Conclusions: Liposuction of the flanks in concert with abdominoplasty does not appear to increase the risk of seroma formation. Patients who are overweight or obese present a statistically significantly higher risk for developing seromas postoperatively than patients of normal weight.
Experimental, or “Reflex”, Induction of Seizures Report of a Case of Abdominal (Enteric) Epilepsy

An unusual case of abdominal epilepsy, of a true enteric type, is presented in great detail. Seizures were characterized initially by abdominal pain, borborygmi, distention, flatus and other gastro‐intestinal symptoms. Secondary manifestations included oculo‐clonic, hemi‐clonic, and generalized tonico‐clonic movements, suggesting a spread of the discharge from a right para‐rhinal epileptogenic focus, for which there was EEG and PEG evidence, to homolateral occipital and motor cortex and eventually to subcortical structures.
Randomized Trial of Codetron for pain Control in Osteoarthritis of the Hip/Knee

Patients suffering from pain due to osteoarthritis of the hip and knee participated in a double-blind placebo controlled trial using daily Codetron home care units for 6 weeks over the tibial, saphenous, popliteal and sciatic nerves, and tender points. Seventy-four percent of patients in the real Codetron (Group A) and 28% of the patients in sham Codetron (Group B) improved their pain level more than 25% as measured by visual analogue scale. The difference in pain improvement in the two groups was statistically significant (p< 0.02 using Fisher's exact probability ratio) Other functional parameters proved to be insensitive to change in this study. This is highly suggestive of beneficial effect of chronic pain conditions such as osteoarthritis.
Avalanche Capability of Vertical GaN p-n Junctions on Bulk GaN Substrates

Inductive avalanche test results presented in this letter demonstrate that GaN p-n diodes can sustain single-pulse and repetitive inductive avalanche currents. The 0.36-mm2 vertical GaN p-n diodes can sustain single-pulse avalanche currents as high as 10 A. The safe zone of the single-pulse avalanche current is limited by peak pulse power and energy deposited in the device. The temperature-dependent behavior of the breakdown voltage and the reverse-voltage at onset of avalanche has a positive temperature coefficient. Repetitive avalanche ruggedness testing was performed by applying 105 pulses at 5-kHz frequency with increasing repetitive stress current. Based on a population of 63 devices, the incremental failure rate under repetitive avalanche current increases with increasing avalanche current. The devices that survive the step stress test sustain no parametric drift under repetitive avalanche.
Integrated network reliability research for AFDX

By discussing network inherent failure mechanism of AFDX (Avionics Full Duplex Switched Ethernet), this paper establishes an integrated reliability analysis architecture of AFDX. Choosing throughput as important indicator, the integrated AFDX reliability evaluation system is established by combining device failures together with PRNR. Finally, by opnet simulation, it shows that workstation quantity and the average packet size are important factors influence integrated network reliability.
Borage consumption as a possible gastric cancer protective factor.

0.18 (95% CI, 0.06-0.52). Considering the level of consumption in four categories (nonconsumers as the referent category and three categories among consumers), the ORs (and 95% Cl) were 0.31 (0.08-1 .18) for the low level of consumption, 0.15 (0.03-0.72) for moderate consumers, and 0.09 (0.02-0.46) for high consumers, showing a clear dose-response relationship (P for trend, 0.0006). These results are based on 88 case-control pairs of residents of the province of Zaragoza. The consumption of borage was extremely low in two areas of the study (Barcelona and Galicia). In the province of Sonia (72 case-control pairs) 22% of controls were consumers (at least 0.5 times a week); the risk for consumers, ad
High state of order of isolated bacterial lipopolysaccharide and its possible contribution to the permeation barrier property of the outer membrane

The conformational properties of the isolated S form of Salmonella sp. lipopolysaccharide (LPS), of Re mutant LPS, and of free lipid A were investigated by using X-ray diffraction and conformational energy calculations. The data obtained showed that LPS in a dried, in a hydrated, and probably also in an aqueous dispersion state is capable of forming bilayered lamellar arrangements similar to phospholipids. From the bilayer packing periodicities, a geometrical model of the extensions of the LPS regions lipid A, 2-keto-3-deoxyoctulosonic acid, and O-specific chain along the membrane normal could be calculated. Furthermore, the lipid A component was found to assume a remarkably high ordered conformation: its fatty acid chains were tightly packed in a dense hexagonal lattice with a center-to-center distance of 0.49 nm. The hydrophilic backbone of lipid A showed a strong tendency to form domains in the membrane, resulting in a more or less parallel arrangement of lipid A units. According to model calculations, the hydrophilic backbone of lipid A appears to be oriented approximately 45 degrees to the membrane surface, which would lead to a shed roof-like appearance of the surface structure in the indentations of which the 2-keto-3-deoxyoctulosonic acid moiety would fit. In contrast, the O-specific chains assume a low ordered, heavily coiled conformation. Comparison of these structural properties with those known for natural phospholipids in biological membranes indicates that the high state of order of the lipid A portion of LPS might be an important factor in the structural role and permeation barrier functions of LPS in the outer membrane of gram-negative bacteria.
The relative performance of four alternative warrant pricing models

Four warrant pricing models are examined in the paper: a pair based on the BS model, a pair based on the constant elasticity of variance (CEV) modification. Based on daily closing price of Shanghai-Shenzhen warrant market from August 2005 to September 2010, and more than 14000 warrant price observations, the FTCEV model generates the lowest mean absolute pricing error in most of the warrants tested. In many cases, the dilution-adjusted Black-Scholes model remains an economical alternative.
A Desire to Be Seen: Family Caregivers' Experiences of Their Caring Role in Palliative Home Care

Primary health care is the base of Swedish healthcare, and many terminally ill patients are cared for at home. A dying relative has a profound impact on his/her family members' situation, including negative effects on roles, well-being, and health. The aim of this study was to explore how the informal carers of a dying relative in palliative home care experienced their caring role and support during the patient's final illness and after death. Fourteen family members were selected in 4 primary health care areas in Sweden. Data were collected using open, tape-recorded interviews. A hermeneutic approach was used to analyze the data. The findings revealed that being an informal carer was natural when a relative became seriously ill. More or less voluntarily, the family member took on a caring role of control and responsibility. The informal carers felt left out and had feelings of powerlessness when they did not manage to establish a relationship with the healthcare professionals. For the informal carers to feel seen, it was necessary for them to narrate about their own supporting role.
Anti-hepatitis B virus activities and absolute configurations of sesquiterpenoid glycosides from Phyllanthus emblica.

During the process exploring anti-viral compounds from Phyllanthus species, eight new highly oxygenated bisabolane sesquiterpenoid glycoside phyllaemblicins G1–G8 (1–8) were isolated from Phyllanthus emblica, along with three known compounds, phyllaemblicin F (9), phyllaemblic acid (10) and glochicoccin D (11). Phyllaemblicin G2 (2), bearing a tricyclo [3.1.1. 1] oxygen bridge ring system, is an unusual sesquiterpenoid glycoside, while phyllaemblicins G6–G8 (6–8) are dimeric sesquiterpenoid glycosides with two norbisabolane units connecting through a disaccharide. All the structures were elucidated by the extensive analysis of HRMS and NMR data. The relative configuration of phyllaemblicin G2 was constructed based on heteronuclear coupling constants measurement, and the absolute configurations for all new compounds were established by calculated electronic circular dichroism (ECD) using time dependent density functional theory. The sesquiterpenoid glycoside dimers 6–9 displayed potential anti-hepatitis B virus (HBV) activities, especially for the new compound 6 with IC50 of 8.53 ± 0.97 and 5.68 ± 1.75 μM towards the HBV surface antigen (HBsAg) and HBV excreted antigen (HBeAg) secretion, respectively.
RNAIII-inhibiting peptide significantly reduces bacterial load and enhances the effect of antibiotics in the treatment of central venous catheter-associated Staphylococcus aureus infections.

BACKGROUND Medical devices used in clinical practice are often associated with biofilm-associated staphylococcal infections. METHODS An in vitro antibiotic susceptibility assay of Staphylococcus aureus biofilms using 96-well polystyrene tissue-culture plates was performed to test the effects of RNAIII-inhibiting peptide (RIP), ciprofloxacin, imipenem, and vancomycin. Efficacy studies were performed using a rat model of central venous catheter (CVC)-associated infection. Twenty-four hours after implantation, the catheters were filled with RIP (1 mg/mL). Thirty minutes later, rats were challenged, via the CVC, with 1.0 x 10(6) cfu of S. aureus strain Smith diffuse. The antibiotic-lock technique was begun 24 h later. RESULTS Minimum inhibitory concentrations of antibiotics in biofilms were at least 4-fold higher than those against the freely growing planktonic cells. When they were first treated with RIP, the cells in biofilms became as susceptible to antibiotics as did planktonic cells. These data were confirmed by the in vivo studies. In particular, when CVCs were treated with both RIP and antibiotics, the biofilm bacterial load was further reduced to 1 x 10(1) cfu/mL, and bacteremia was not detected, suggesting that there was 100% elimination of bacteremia and a 6 log10 reduction in biofilm bacterial load. CONCLUSION RIP significantly reduces bacterial load and enhances the effect of antibiotics in the treatment of CVC-associated S. aureus infections.
Knowledge, attitude and practice (KAP) concerning cervical cancer and screening among rural and urban female healthcare practitioners in the Democratic People's Republic of Korea.

BACKGROUND AND OBJECTIVE Little is known about cervical cancer (CC) in the Democratic People's Republic of Korea (DPRK). This study examines the knowledge, attitudes and practices (KAP) concerning CC and screening among female health care practitioners (HCPs), and whether differences exist between rural and urban HCPs. METHOD In a descriptive cross-sectional study, a purposive sample of 200 women HCPs from 128 health care centers in 6 provinces of DPRK was interviewed using a standardized questionnaire. RESULTS 98% of HCPs were aware of CC. Awareness of the national CC policy was significantly lower in rural (44%) than urban (62%) respondents (p<0.05). Fewer rural (71%) than urban (89%) HCPs knew of cervical cytology (p<0.05). Around 30% of HCPs were aware of the association between CC and human papillomavirus infection. Only 13% of HCPs had ever had a cervical cytology smear. Only 4% of rural and 21% of urban practitioners (p<0.05) provided cytology; all used unaided visual inspection of the cervix without staining to determine whether cytology testing was indicated. For all, screening intervals depended on presence of symptoms. CONCLUSION Misconceptions and ineffective clinical practices regarding screening need to be urgently addressed among both rural and urban HCPs. There are no major differences between rural and urban HCPs regarding their KAP.
Assessing the economic challenges posed by orphan drugs: A comment on Drummond et al.

To the Editor: In a recent study in this Journal, Drummond and colleagues (5) attempt to address the question “Whether the standard methods of HTA are adequate for assisting decisions on patient access to and funding of orphan drugs” before proposing “a research agenda to help understand the societal value of orphan drugs and issues surrounding their development, funding, and use. ”
Influência da genética bovina na suscetibilidade ao estresse durante o manejo e seus efeitos na qualidade da carne

A presente tese apresenta quatro trabalhos que visam caracterizar o temperamento de dois grupos geneticos e suas influencias na producao e qualidade de carne produzida na Regiao Sul do RS. O primeiro refere-se a avaliacao do temperamento em animais criados extensivamente, bem como a avaliacao da qualidade da carne produzida, atraves do pH e niveis de cortisol. Foram estudados 40 machos castrados, de dois grupos geneticos Bos taurus taurus e Bos taurus taurus x Bos taurus indicus . Houve uma associacao linear positiva entre a presenca de sangue zebu e reatividade. A variavel ganho de peso foi negativamente correlacionada com o escore comportamental medio. Nao houve diferenca significativa entre os grupos geneticos quanto ao ganho de peso. Em relacao a qualidade de carne, foram encontradas diferencas significativas de pH entre os grupos geneticos e entre as classes de temperamento. O segundo trabalho avaliou o temperamento de bovinos mantidos em confinamento, representados por 79 machos castrados, divididos de acordo com oito graus de sangue Charoles x Nelore. Houve uma associacao linear negativa entre escore composto e grupo genetico, xv verificando-se que, com o aumento da participacao de sangue Charoles, diminuiram os valores. Os animais com maior porcentagem de sangue Charoles apresentaram maior ganho de peso e maiores valores iniciais de pH da carcaca. Nao foram encontradas diferencas para as caracteristicas capacidade de retencao de agua e nivel plasmatico de cortisol. O terceiro trabalho caracterizou o temperamento de bovinos de corte durante a sua permanencia em pista de remate. Foram utilizados 1572 bovinos pertencentes a dois grupos geneticos ( Bos taurus taurus x Bos taurus indicus" e "Bos taurus taurus ). Os animais cruzados apresentaram maiores valores de escores de entrada e movimentacao em pista. Os machos apresentaram menor reatividade quando comparados as femeas para os escores de entrada e movimentacao em pista. O quarto trabalho avaliou o efeito do genotipo sobre o temperamento de bovinos criados extensivamente. Foram utilizados 163 machos castrados de dois grupos geneticos cruzados e puros. Os animais puros indianos apresentaram maior reatividade ao manejo. O genotipo pode modular o temperamento de bovinos de corte criados tanto extensivamente como intensivamente e afetar o ganho de peso e algumas caracteristicas da carcaca e carne.
A Formal Approach to the Design and Assembly of Mobile Toolkits

It is widely believed that the design of transported artifacts and toolkits employed by mobile populations is influenced by two main factors, portability and potential utility. Choices about the kinds of artifacts to carry around can be modeled as an optimization problem, in which it is beneficial to obtain the greatest potential utility for the minimum total weight. This study approaches the problem analytically, making a few simple assumptions about artifact geometry and the relations between utility and artifact size. If artifact utility is calculated as a function of potential for renewal, transported toolkits should consist entirely of relatively small finished tools. Moreover, most gains in durability or multifunctionality that require increases in overall size are outweighed by increased transport cost. Inconsistencies between these expectations and ethnographic and archaeological observations point to situations in which artifact functionality is more closely constrained by overall size or mass.
Endogenous Cannabinoids: Structure and Metabolism

The finding of specific binding sites for Δ9‐tetrahydrocannabinol, the psychoactive component of Cannabis sativa, has led to the discovery of the endocannabinoid system and has emphasised the physiological and pathological relevance of endocannabidoid lipid signalling. Subsequently, an increasing number of papers have been published on the biochemistry and pharmacology of endocannabinoids. An overview of the current understanding of structure and metabolism of the best studied endocannabinoids is provided, with a focus on the mechanisms responsible for their biosynthesis and inactivation.
Combined analysis of short-baseline neutrino experiments in the (3 + 1) and (3 + 2) sterile neutrino oscillation hypotheses

We investigate adding two sterile neutrinos to resolve the apparent tension existing between short-baseline neutrino oscillation results and CPT-conserving, four-neutrino oscillation models. For both (3+1) and (3+2) models, the level of statistical compatibility between the combined dataset from the null short-baseline experiments Bugey, CHOOZ, CCFR84, CDHS, KARMEN, and NOMAD, on the one hand; and the LSND dataset, on the other, is computed. A combined analysis of all seven short-baseline experiments, including LSND, is also performed, to obtain the favored regions in neutrino mass and mixing parameter space for both models. Finally, four statistical tests to compare the (3+1) and the (3+2) hypotheses are discussed. All tests show that (3+2) models fit the existing short-baseline data significantly better than (3+1) models.
Utilização de métodos auxiliares na identificação endoparasitária em ovelhas no Amazonas

A verminose e causada por varias especies de helmintos que parasitam o trato gastrintestinal dos ovinos, causando baixa produtividade e altos indices de morbidade e mortalidade. Objetivou-se avaliar o metodo que se observa a coloracao da conjuntiva ocular, conhecida como metodo Famacha, como estrategia auxiliar na identificacao da carga parasitaria nos animais. Foi realizado em conjunto o metodo de contagem de ovos de parasitas por grama de fezes (OPG). Foi utilizado 18 ovelhas de padrao racial Santa Ines. O acompanhamento parasitario pelas duas metodologias ocorreu no periodo de novembro de 2011 a abril de 2012. As avaliacoes pelos metodos Famacha e OPG foram realizadas mensalmente e individualmente nas ovelhas para o controle. A escala do metodo Famacha observado variou de 1 a 3 que correspondeu de 0 a 6.500 OPG. Ao termino do experimento, ocorreu reducao de 64,8% na utilizacao de medicacao antiparasitaria nas ovelhas. O metodo Famacha foi eficiente na identificacao dos animais que necessitavam de tratamento antiparasitario para Haemonchus contortus e reduziu a frequencia de dosificacoes de anti-helmintico.
General practitioners trained in motivational interviewing can positively affect the attitude to behaviour change in people with type 2 diabetes

Objective. To examine whether training GPs in motivational interviewing (MI) can improve type 2 diabetic patients’ (1) understanding of diabetes, (2) beliefs regarding prevention and treatment, and (3) motivation for behaviour change. Methods. A randomized controlled trial including 65 GPs and 265 type 2 diabetic patients. The GPs were randomized in two groups, one with and one without MI training. Both groups received training in target-driven intensive treatment of type 2 diabetic patients. The intervention was a 1½-day residential course in MI with ½-day follow-up twice during the first year. The patient data stemmed from previously validated questionnaires. Main outcome measures. The Health Care Climates Questionnaire assesses the patient–doctor relationship and type of counselling. The Treatment Self-Regulation Questionnaire assesses the degree to which behaviour tends to be self-determined. The Diabetes Illness Representation Questionnaire assesses beliefs and understanding of type 2 diabetes. The Summary of Diabetes Self Care Activities assesses the extent of various self-care activities related to type 2 diabetes. Results. The response rate to our questionnaires was 87%. Patients in the intervention group were significantly more autonomous and motivated in their inclination to change behaviour after one year compared with the patients from the control group. Patients in the intervention group were also significantly more conscious of the importance of controlling their diabetes, and had a significantly better understanding of the possibility of preventing complications. Conclusion. MI improved type 2 patients’ understanding of diabetes, their beliefs regarding treatment aspects, their contemplation on and motivation for behaviour change. Whether our results can be sustained long term and are clinically relevant in terms of changes in risk profile advocates further research.