Miracle-dz/UniFAR-FTUs huggingface dataset:
What NEW Technologies are Needed to Halt Bleeding in the Most Severe Cases of Hemorrhage? Can This be Achieved by Enhancing Delivery of Therapeutics to the Wound?

Uncontrolled bleeding is a leading cause of death across all socioeconomic backgrounds, and can arise from diverse scenarios, including trauma, surgery, and childbirth [1]. Current strategies for treating hemorrhage include transfusing blood products, such as platelets, as well as delivering hemostatic and anti-fibrinolytic agents designed to stop the flow of blood or prevent clot lysis. The early control of hemorrhage drastically improves the outcome for patients; however, challenges still exist for managing severe, intractable hemorrhage, which is characterized by platelet dysfunction, increased clot lysis, and poor clot adhesion. Furthermore, escaping blood pushes externally applied hemostatics away from the wound, preventing delivery of the therapeutic to the site of injury. Platelets seal vascular damage by adhering to blood vessel walls, releasing molecules which promote platelet activation and clot formation, and contracting the clot to narrow the wound. A promising strategy for the management of intractable hemorrhage is to increase the responsiveness, adhesion, and hemostatic e cacy of platelets specifically at sites of vascular damage. This has been achieved in part by use of refrigerated platelets. Compared to platelets stored at room temperature, which is the standard temperature for platelet storage, refrigerated platelets show higher e cacy when used to treat acute bleeding [2]. However, refrigerated platelets only circulate for a short time before they are cleared by the reticuloendothelial system, limiting the ability of refrigerated platelets to prevent bleeding when used prophylactically. There is evidence that genetic modification can be used to enhance the hemostatic e cacy of platelets. In animal models, genetically engineered platelets were shown to improve hemophilia by releasing coagulation factor VIII [3]. These platelets are generated by modifying platelet precursor cells. While platelets can be generated from cultured precursor
Modified Ultra Fast Pap Stain in Cytology in Comparision with Regular Pap Stain and MGG

Quick diagnosis of Fine needle aspiration cytology (FNAC) plays an important role in efficient medical practice. Few rapid stains available these days include MGG, Diff quick and toluidine blue stain. However many cytopathologists prefer the transparent, traditional, crisp nuclear features offered by wet fixed PAP stain rather than air dried Romanowsky stain. To overcome this, Ultrafast Papanicolaou stain was introduced, which is a hybrid of Romanowsky and PAP stain. This method reduce reduces the staining time to 90 seconds because of the use of fixative like alcoholic formalin and also enhances staining the quality. Our study is to assess the use of modified ultra-fast pap stain in Fine needle aspiration cytology of various organs in comparison with the standard conventional PAP and MGG stain. MATERIALS AND METHODS : This prospective study was carried out in Department of pathology, Coimbatore medical college, Coimbatore. It includes100 cases, FNA from thyroid, breast, and lymph node lesions. Minimum 3 smears made and stained with routine Pap, MGG and MUFP stain. All smears were compared in 6 parameters and Quality index is calculated. RESULTS : MUFP is a excellent staining method for studying FNA material from all three organs like thyroid breast and lymph node lesions. PAP stain is excellent for staining crisp nuclear chromatin. MGG stain showed less air drying artifacts compared to wet fixed smears and has better optimal cytoplasmic feature. CONCLUSION : MUFP staining is quick, reliable and can be done with easily available reagents and is very useful in countries like India.
Uterine artery Doppler as a predictor of pre eclampsia - hospital based study

Aim: Study of early second trimester (13-16wks) uterine artery Doppler as predictor of pre eclampsia. Objective: To study whether early changes in uterine artery Doppler have better predictive value for preeclampsia as compared to gestational hypertension. To analyze the maternal and fetal outcome in cases with pre eclampsia vs gestational hypertension. Material & Methods: From 2009 to 2011, we conducted an institutional based study among 100 pregnant women. Uterine artery Doppler was done in the women in early second trimester during the antenatal visits at Niloufer Hospital. We measured and recorded the BP, urine analysis, complete blood work done in every antenatal visit. These women were followed up to their delivery. Data were analyzed and p<0.05 was considered significant. Results: Pre eclampsia developed in 31.25% of the pregnant women with bilateral uterine artery notching at 13-16 weeks of gestational age Odds ratio of patients developing hypertension with uterine artery notching is 6.6. Chi-square = 11.8, P value < 0.0005 (significant). This study has a sensitivity of 71.42%, specificity of 74.41%, positive predictive value of 31.25% and negative predictive value of 94.11% in predicting onset of preeclampsia in pregnancy. Conclusion: Uterine artery Doppler should be done routinely in all pregnant women as risk factors can be identified at an early stage where timely intervention can reduce the maternal and neonatal complications.
A Systematic Review of Culturally Tailored Obesity Interventions among African American Adults

ABSTRACT Background: African Americans have the highest age-adjusted rates of obesity at 48.1%. High rates of obesity contribute to the disproportionate share of chronic health conditions. In order to reduce these high rates and achieve health equity, intervention programs must address racial health disparities in culturally meaningful ways. Methods: The purpose of this investigation was to systematically review culturally tailored interventions conducted between 2005 and 2015 aimed at reducing obesity among African American adults. Several databases were used with search terms “African American adults,” obesity,” and “intervention. ” Inclusion and exclusion criteria were used. Results: The search returned a total of 147 hits and after the 3-phase data extraction process, 8 studies met inclusion and exclusion criteria. Discussion: The interventions focused on individual-level change and most included a primarily female sample. Faith-based settings appear to be an ideal setting. Given the small amount of studies conducted over the past decade, there is a need for more interventions that use culturally appropriate strategies. Translation to Health Education: Sociocultural and constituent-involving strategies appear to allow meaningful interaction with communities and may help with the high attrition rate. Age and gender should be a focus, in addition to race, when planning interventions.
Spectroscopic and Theoretical Studies of Potential Anti-Inflammatory Polycyclic Aromatic Fluorophenyl Substituted Acyclic and Heterocyclic Analogues Synthesized from 4,4′-Difluorophenylchalcone

Abstract The first principle calculations were performed using the B3LYP/cc-pVDZ level to find the structural and geometrical parameters, vibrational wavenumbers and various molecular properties of three fluorophenyl derivatives, 3,5-bis(4-fluorophenyl)isoxazole (BISFPI), 2,3-dibromo-1,3-bis(4-fluorophenyl)-prop-1-one (BFPH) and 4,6-bis(4-fluorophenyl)-2-phenyl-1H-indazol-3(2H)-one (FPPIH). The experimental bands are compared with theoretical wavenumbers and assigned using potential energy distribution analysis. The VCD spectrum is produced by the ring stretching modes are efficient configuration markers. The first hyperpolarizabilities of BISFPI, BFPH and FPPIH are respectively, 10.25, 33.82 and 20.34 times that of urea and hence good objects for further studies in nonlinear optics. Molecular electrostatic potential maps can suggest the sites which are prone from attack of the electron loving and nucleophilic systems. NBO analysis gives the stability of molecules arising from hyper conjugative interactions. In the case of molecules under study, molar refractivity values are increasing in the order, FPPIH > BFPH > BISFPI and this is responsible for the binding nature of the molecular systems. The docked ligands form stable complexes with the receptor arylmalonate decarboxylase inhibitor and the docking studies suggest that these compounds can be developed as new anti-inflammatory drugs.
Understanding Chinese Millennials' Adoption Intention Towards Third-Party Mobile Payment

Different user groups will tend to value different third-party mobile payment offerings differently, and so make different adoption decisions. Millennials are regarded as creative, socially conscious and more willing to provide opinions on the advantages and disadvantages of new technologies. Therefore, it is important to investigate the key factors that affect Chinese Millennials' adoption behavior of third-party mobile payments as they grow in popularity in China. This study establishes a new conceptual model based on the Technology Acceptance Model incorporating additional variables such as perceived risk, personal innovativeness, compatibility, and social influence. This research collected quantitative data by questionnaire (N=380). The data was analyzed by SPSS. This study suggests that social influence and attitude directly affect adoption intention towards third-party mobile payments, whereas perceived usefulness, compatibility, perceived ease of use and personal innovativeness only indirectly affect adoption intention towards third-party mobile payments.
Max India Group: How to Create a Culture of Maxism?

Abstract Max India is a multi-business entity and is the holding company for Max Healthcare, Max Bupa Health Insurance, Antara Senior Living, Life Insurance and Max Speciality Films. The case describes how an enterprise-wide quality management system can help achieve the vision of the Max Group, which is to build one of the most admired corporates for service excellence, and how can quality and service excellence become a boardroom subject? The case lists down the details of different businesses and the perspective of different stakeholders in the implementation of the Max Performance Excellence Framework and building the culture of Maxism. The case was written based on both primary research (interview research) and secondary research.
Novel Collagen Markers for Early Detection of Bone Metastases in Breast and Prostate Cancer Patients

Background: Maintenance of the structural and functional integrity of the skeleton is a critical function of a continuous remodeling driven by highly associated processes of bone resorption and synthetic activities driven by osteoclasts and osteoblasts, respectively. Acceleration of bone turnover, accompanied with a disruption of the coupling between these cellular activities, plays an established role in the pathogenesis of metabolic bone diseases, such as osteoporosis. During the past decades, major efforts have been dedicated to the development and clinical assessment of biochemical markers that can reflect the rate of bone turnover. Numerous studies have provided evidence that serum levels or urinary excretion of these biomarkers correlate with the rate of bone loss and fracture risk, proving them as useful tools for improving identification of high-risk patients. Objective: The aim of the present review is to give an update on biomarkers of bone turnover and give an overview of their applications in epidemiological and clinical research. Discussion: Special attention is given to their utility in clinical trials testing the efficacy of drugs for the treatment of osteoporosis and how they supplement bone mass measurements. Recent evidence suggests that biochemical markers may provide information on bone age that may have indirectly relates to bone quality; the latter is receiving increasing attention. A more targeted use of biomarkers could further optimize identification of high-risk patients, the process of drug discovery, andmonitoring of the efficacy of osteoporosis treatment in clinical settings.
Promoting Evidence-Based Practice Through a Live Online Nursing Journal Club: It Takes a Team

ABSTRACT Journal clubs have existed for 150 years for clinicians to discuss the latest evidence, yet multiple barriers exist. Rapid healthcare changes provide new opportunities for librarians to promote modern journal clubs. An interdisciplinary team of librarians, nursing faculty, and a continuing education program manager designed, conducted, and evaluated a live journal club for nurses located throughout the United States. Five sessions were conducted and 11 RNs participated. Participants’ Evidence-Based Practice Belief Scale scores and survey responses were encouraging. Journal clubs led by an interdisciplinary team are one way to embrace change while supporting clinicians.
Energy self-sufficient sensor node for long range wireless networks

Wireless networks can have different architectures depending on the application context. In this paper, we concentrate on a wireless network that supports a gateway to a server being accessible from the internet. Many typical related applications can be found in IoT and Industry 4.0. Focus of this paper is on the design of a sensor node that is energy self-sufficient and supports the LoRa communication standard. By using LoRa long range wireless communication of up to several kilometres range becomes possible. Therefore, large areas can be covered by using multiple sensor nodes. Special attention had been on low-power design aspects to run the node with rechargeable battery and small photovoltaic cell only. Example application is ambient monitoring and support of an aquaponics project.
Gait analysis for Alzheimer’s disease therapies using Kinect™: A preliminary report

Alzheimer’s disease (AD) is the most common form of dementia. The symptoms include cognitive impairment and gait disturbances. Gait analysis reports showed that people with AD have slower gait speed, shorter step lengths, and lower step frequency. It was suggested that gait analyses may be important for therapies and diagnosis. However, recent gait analysis reports still involved floor sensors and wearable sensors, which may not be convenient for elderly patients. In this report, we proposed the use of Kinect™ device: a machine vision gait analysis approach. This device has been used for rehabilitation purposes in elderly care and stroke rehabilitation. Furthermore, it has been used in neurodegenerative disease studies. In this report, we would like to extract the gait components of a person based on the Kinect™ 25-joint system. It started with two subjects walking down a measurement aisle 5 times. The recorded videos of the 2 subjects were subsequently interpreted into the position of joints over time following the Cartesian coordinate. Next, we extracted the gait components manually from the joints involved in determining gait components (left foot & right foot) using a Microsoft Excel software. The result validation was done using t-tests comparing the gait components of the 2 subjects. It was shown that the results were valid, which opens an opportunity to use this device for AD therapies.Alzheimer’s disease (AD) is the most common form of dementia. The symptoms include cognitive impairment and gait disturbances. Gait analysis reports showed that people with AD have slower gait speed, shorter step lengths, and lower step frequency. It was suggested that gait analyses may be important for therapies and diagnosis. However, recent gait analysis reports still involved floor sensors and wearable sensors, which may not be convenient for elderly patients. In this report, we proposed the use of Kinect™ device: a machine vision gait analysis approach. This device has been used for rehabilitation purposes in elderly care and stroke rehabilitation. Furthermore, it has been used in neurodegenerative disease studies. In this report, we would like to extract the gait components of a person based on the Kinect™ 25-joint system. It started with two subjects walking down a measurement aisle 5 times. The recorded videos of the 2 subjects were subsequently interpreted into the position of joints over time fo.
Tubular Biomarkers as Diagnostic Tools in Diabetic Kidney Disease: A Review of Published Evidence

Microalbuminuria predicts the onset and progression of diabetic nephropathy. Despite its use as the conventional glomerular biomarker for early detection of diabetic kidney disease, its predictive accuracy is not optimal because of some disadvantages. Since tubular injury occurs early in the course of diabetic nephropathy, tubular biomarkers should be more sensitive than microalbuminuria as early predictors of the disease. The present review aims to discuss the tubular biomarkers currently used as diagnostic tools in diabetic nephropathy. Using a combination of terms such as ‘diabetic nephropathy and pathogenesis’, ‘biomarkers and diabetic nephropathy’, ‘tubular biomarkers and diabetic nephropathy’ and ‘diabetic nephropathy risk and predictors’, the Pubmed data base was searched for articles which met the objective of the review. Tubular biomarkers reported as predictors of diabetic kidney disease consist of cystatin C, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, alpha 1-microglobulin, N-acetylβ-D-glucosaminidase, and liver-type fatty-acid binding protein. Several studies show that these markers are not only more sensitive, but are much earlier predictors of diabetic nephropathy than microalbuminuria. Although their advantages over microalbuminuria are evidence-based, majority still need to be validated for diagnostic purposes.
Surgery without knife: an ideal treatment for lactational breast abscess

Breast abscess is common in lactating females. The incidence of breast abscess ranges from 0.4 to 11% of all lactating mothers. Risk factors for the development of breast abscess are milk stasis by duct blockage, stress, sore nipples or infrequent breastfeeding. Other risk factors for abscess formation include maternal age over 30 years, gestational age greater than 41 weeks and a history of mastitis. The pathogen most commonly Staphylococcus aureus enter into breast via cracked nipple specially in primipara due to inexperience, poor feeding technique and poor attachment by baby. Breast abscess is common in developing countries due to poor maternal hygiene, decreased nutrition, poor standard of living, delay in antibiotics administration and poor breastfeeding techniques. Patient having breast abscess presents with symptoms of pain, swelling and redness of the involved breast. There may be associated fever, malaise and occasionally rigors.
Twenty‐eight‐gigahertz beam‐switching ridge gap dielectric resonator antenna based on FSS for 5G applications

A new design of the double dielectric resonator antenna (DRA) fed by a printed ridge gap waveguide for beam-switching applications based on frequency selective surfaces (FSSs) is presented here. The dual-sided printed FSS element works in its reflection mode and comprises a slotted square C-shaped patch on the top layer and a square strip on the back plane. Therefore, the beam switching can be implemented by loading the proposed FSS array over and in the middle of DRAs. Loading the antenna with two layers of 3 × 3 FSS unit cells results in ±77° beam switching and a 3.16 dBi gain enhancement at 28 GHz. Simulation and measurements confirm the operation of the proposed antenna, with good matching and gain observed.
Modeling Language for Systems Engineering in Defense Industry

Systems engineering work begins with the concept of product design, product development and product implementation. The relationships between each step are complicated. This article is presenting the symbolic language that develops for managing the complexity in system engineering. The applications of this language are assisting in explaining the relationships as a blueprint that describes the details of the various parts especially defense industry.
VP168 Assessment Of Plasmapheresis For Alzheimer's Disease Systematic Review

INTRODUCTION: Alzheimer's disease (AD) is the most common type of dementia. Plasmapheresis is a procedure consisting of removing the plasma, or specific elements which are considered to be involved in pathological processes. Plasmapheresis could reduce the A beta peptides load in the brain. The objective is to study the safety and efficacy of plasmapheresis for AD. METHODS: Systematic review, with all studies published before April 2016 reviewed. Selected studies included patients with AD treated with plasmapheresis. GRADE was used to assess quality. Efficacy outcomes include: (i) Cognitive, functional and behavior status, through Mini Mental State Examination, and Alzheimer Disease Assessment Scale-Cognitive test; (ii) Plasma and cerebrospinal fluid A beta levels; (iii) Brain-imaging and functional neuroimaging studies. Safety outcomes included side effects related to the treatment. RESULTS: Two papers reporting results from three studies were selected: (i) pilot study (n = 10), (ii) its extended study (12 months more of follow-up) (n = 7), and (iii) clinical trial (n = 39). The quality of evidence was very low. About efficacy, the studies didn't report quantitative results and were inconclusive. The pilot study and its extended study reported (1): a tendency towards stabilization in cognitive status; the plasma levels of A beta peptides didn't show a clear pattern; and the brain-imaging assessment suggested a progressive volume increase in the hippocampus. The clinical trial reported in the experimental group vs control (2): a better score for the cognitive status; an increase of plasma A beta peptides; and did not find significant differences between groups for cerebrospinal fluid A beta peptides. The brain-imaging assessment showed a progressive loss of hippocampus volume in both groups. Regarding safety, the studies didn't report quantitative data. We didn't find economic evaluation studies. CONCLUSIONS: The included studies had very high risk of bias and very low quality. We found no evidence on efficacy and safety of plasmapheresis treating AD. Plasmapheresis isn't a priority line in research of AD treatment.
Innovation Contests: How to Design for Successful Idea Selection

Innovation contests provide several benefits, but many organizations struggle with managing emergent challenges that occur during the idea selection process. This paper builds on qualitative interviews, where practitioners shared their experiences with managing innovation contests. Across the 13 contest domains studied in 31 cases, we identified five frequently occurring contest goals: (1) promote entrepreneurship, (2) collect innovative ideas, (3) elevate awareness, (4) explore market opportunities, and (5) find talent that influence the design of the selection process. Moreover, for five common emergent challenges we identified how practitioners apply manual and IT-enabled coping strategies, which can be associated with three design elements, i.e., the (1) ideas for the innovation, the (2) raters of the ideas, and the (3) duration of the selection process. These findings are summarized in a guiding framework that helps practitioners design, navigate, and manage the complex process of idea selection.