Miracle-dz/UniFAR-FTUs huggingface dataset:
Information Technology in value shop Activities: An exploratory study of Knowledge Reuse in norwegian Police investigations

It has long been argued that knowledge reuse is positively related to the extent of information technology use in organizations. This article reports results from an exploratory survey of police investigation units in Norway to develop a research model linking knowledge reuse to IT use. Police investigation units are defined as value shops, where problems are solved in five primary activities.
Three Thiadiazinone Derivatives, EMD 60417, EMD 66430, and EMD 66398, with Class III Antiarrhythmic Activity but Different Electrophysiologic Profiles

&NA; The thiadiazinone derivatives EMD 60417, EMD 66430, and EMD 66398 were developed as class III antiarrhythmic agents. Their chemical structure is closely related to that of their calcium‐sensitizing congener [+]‐EMD 60263, and EMD 66398 possesses the methylsulfonylaminobenzoyl moiety present in the prototypical IKr blocker E‐4031. We compared the electrophysiologic effects of these compounds with standard drugs (almokalant, E‐4031, quinidine) in cardiac myocytes from guinea‐pig ventricle and human atrium by whole‐cell patch‐clamp technique. The test compounds' class III action, which is related to impairment of K+ channel function, was confirmed by action potential measurements. EMD 60417, EMD 66430, EMD 66398, and almokalant (1 &mgr;M each) reversibly prolonged the action potential duration in guinea‐pig myocytes. In the same cells, the rapidly activating component IKr of the delayed rectifier K+ current, which has been defined by its sensitivity to E‐4031, was reduced by EMD 60417, EMD 66430, EMD 66398, and almokalant. Inhibition of IKr was concentration‐dependent as determined by attenuation of tail currents. The slowly activating component IKs of the delayed rectifier K+ current was not affected. The inward rectifier K+ current IK1 was not influenced at potentials close to the reversal potential. Transient and sustained outward K+ currents (Ito, Iso) measured in human atrial myocytes were not altered by any EMD compound. L‐type Ca2+ current was hardly affected at concentrations of 1–10 &mgr;M, but sodium current was decreased. Action potential prolongation by EMD 60417, EMD 66430, and EMD 66398 is due to block of IKr. INa is inhibited at higher concentrations by EMD 66430 and EMD 60417. EMD 66398 is more potent and selective for IKr than EMD 60417 and EMD 66430, and thus resembles E‐4031 in structure and function.
The optimization and application of DDR controller based on multi-core system

An application to improve the performance of DDR memory controller based on network processor is described in this paper. The DDR memory controller is designed to prefetch instructions to get the address relationship of consecutive instructions in advance. The controller can be able to utilizing the policy of Open Page or bank interleaving while the current instruction is executing. The performance of interfacing Virtex-II FPGA to DDR shows that the DDR memory controller can reduce access latency of DDR memory.
ARIPIPRAZOLE: A REVIEW OF ITS PHARMACOLOGY AND CLINICAL USE

Atypical antipsychotics generally have a lower propensity for extrapyramidal side‐effects (EPSE), hyperprolactinaemia and tardive dyskinesia than that associated with typical antipsychotics but may still produce troublesome side‐effects, such as weight gain, cardiac rhythm changes and impaired glucose tolerance. Aripiprazole is a new atypical antipsychotic with a unique receptor binding profile that combines partial agonist activity at D2 and 5HT1A receptors with potent antagonism at 5HT2A receptors. Clinical studies in acute schizophrenic relapse, chronic schizophrenia and acute mania show it is robustly more effective than placebo. Once‐daily aripiprazole 15–30 mg is as effective as haloperidol 10 mg/day and risperidone 6 mg/day in short‐term treatment of schizophrenia and more effective than haloperidol 7–10 mg/day in maintenance of response in chronic schizophrenia. Aripiprazole appears to be well tolerated, with most studies suggesting a frequency of adverse effects similar to placebo. Aripiprazole seems not to cause significant EPSE, hyperprolactinaemia, excessive weight gain or cardiac rhythm disturbance. Limited data suggest that aripiprazole is not associated with impaired glucose tolerance.
Phenotypic Diversity of EnterotoxigenicEscherichia coli Strains from a Community-Based Study of Pediatric Diarrhea in Periurban Egypt

ABSTRACT No past studies of diarrhea in children of the Middle East have examined in detail the phenotypes of enterotoxigenic Escherichia coli (ETEC) strains, which are important pathogens in this setting. During a prospective study conducted from November 1993 to September 1995 with 242 children under 3 years of age with diarrhea living near Alexandria, Egypt, 125 episodes of diarrhea were positive for ETEC. ETEC strains were available for 98 of these episodes, from which 100 ETEC strains were selected and characterized on the basis of enterotoxins, colonization factors (CFs), and O:H serotypes. Of these representative isolates, 57 produced heat-stable toxin (ST) only, 34 produced heat-labile toxin (LT) only, and 9 produced both LT and ST. Twenty-three ETEC strains expressed a CF, with the specific factors being CF antigen IV (CFA/IV; 10 of 23; 43%), CFA/II (5 of 23; 22%), CFA/I (3 of 23; 13%), PCFO166 (3 of 23; 13%), and CS7 (2 of 23; 9%). No ETEC strains appeared to express CFA/III, CS17, or PCFO159. Among the 100 ETEC strains, 47 O groups and 20 H groups were represented, with 59 O:H serotypes. The most common O serogroups were O159 (13 strains) and O43 (10 strains). O148 and O21 were each detected in five individual strains, O7 and O56 were each detected in four individual strains, O73, O20, O86, and O114 were each detected in three individual strains, and O23, O78, O91, O103, O128, and O132 were each detected in two individual strains. The most common H serogroups were H4 (16 strains), 12 of which were of serogroup O159; H2 (9 strains), all of which were O43; H18 (6 strains); H30 (6 strains); and H28 (5 strains); strains of the last three H serogroups were all O148. Cumulatively, our results suggest a high degree of clonal diversity of disease-associated ETEC strains in this region. As a low percentage of these strains expressed a CF, it remains possible that other adhesins for which we either did not assay or that are as yet undiscovered are prevalent in this region. Our findings point out some potential barriers to effective immunization against ETEC diarrhea in this population and emphasize the need to identify additional protective antigens commonly expressed by ETEC for inclusion in future vaccine candidates.
Serum adipokines (adiponectin and resistin) correlation in developing gestational diabetes mellitus: pilot study

Abstract Adiponectin and resistin are adipose tissue-derived proteins with antagonistic actions; adiponectin has insulin sensitive properties while resistin is involved in the development of insulin resistance. We analyzed adiponectin and resistin levels in gestational diabetes mellitus (GDM) women to evaluate the association of these adipokines in a very high diabetes prevalence population. An age-matched case-control study of GDM and normal pregnant women in Saudi population. We recruited 90 pregnant women at 24–32 weeks of gestation. Glucose levels (fasting, 1, 2, and 3 h) and lipid parameters (cholesterol, triglyceride, HDL cholesterol, LDL cholesterol) were measured. Serum adiponectin and resistin levels were analyzed using Randox evidence biochip analyzer. Pearson’s correlation coefficient was used to determine the association of adiponectin and resistin with GDM risk factors. GDM women showed significantly low adiponectin and high resistin levels when compared with control group. Pearson’s correlation analysis of adiponectin and resistin in all the subjects with various GDM risk factors showed a negative association of adiponectin (r = −0.32, p = .05) and a positive correlation of resistin (r = 0.41, p = .01) with LDL cholesterol. This study analyzes adiponectin and resistin levels together, as accumulating evidences shows that these are involved in the pathophysiology of GDM. This is going to help to determine in conjunction with traditional risk factors the incremental value of circulating adiponectin and resistin in developing GDM.
Unobserved heterogeneity and self-selection: Essays in labor economics and international trade

The first chapter of this dissertation focuses on the heterogeneity in earnings losses of displaced workers. A large literature shows that workers, on average, suffer large and persistent earnings losses when displaced from a job. However, little attention has been devoted to the distribution of those losses. Using the 1994-2014 Current Population Survey displaced worker surveys, I find that averages, whether from simple summary statistics or calculated as expectations using ordinary least squares (OLS), give a misleading and incomplete picture. The average loss in earnings in my sample is 29%, compared with a median loss of just 12%. Using OLS, each year of tenure is associated with an additional 1.3% reduction in earnings. Quantile regression estimates reveal that this magnitude of effect corresponds to the 80th percentile, and that the effect of tenure at the median is just 0.7%. OLS estimates of the effect of changing industries and occupations are also considerably larger than quantile regressions at or below the median. I also attempt to correct for possible endogeneity in the choice to switch industry and occupation. Two-stage least squares estimates yield even larger estimated negative effects of changing industry and occupation than OLS, but instrumental variables quantile regression estimates, using the model developed by Chernozhukov and Hansen (2005), suggest that the marginal effects on such losses are highly concentrated among relatively few workers. Finally, I demonstrate that there is a positive relationship between the magnitude of earnings losses and the level
Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance.

Tyrosine phosphorylation of a 17-amino acid immunoreceptor tyrosine-based activation motif (ITAM), conserved in each of the signaling subunits of the T-cell antigen receptor (TCR), mediates the recruitment of ZAP-70 and syk protein-tyrosine kinases (PTKs) to the activated receptor. The interaction between the two tandemly arranged Src-homology 2 (SH2) domains of this family of PTKs and each of the phosphotyrosine-containing ITAMs was examined by real-time measurements of kinetic parameters. The association rate and equilibrium binding constants for the ZAP-70 and syk SH2 domains were determined for the CD3 epsilon ITAM. Both PTKs bound with ka and Kd values of 5 x 10(6) M-1.sec-1 and approximately 25 nM, respectively. Bindings to the other TCR ITAMs (zeta 1, zeta 2, gamma, and delta ITAMs) were comparable, although the zeta 3 ITAM bound approximately 2.5-fold less well. Studies of the affinity of a single functional SH2 domain of ZAP-70 provided evidence for the cooperative nature of binding of the dual SH2 domains. Mutation of either single SH2 domain decreased the Kd by > 100-fold. Finally, the critical features of the ITAM for syk binding were found to be similar to those required for ZAP-70 binding. These data provide insight into the mechanism by which the multisubunit TCR interacts with downstream effector molecules.
Quantitative differences in adhesiveness of type 1 fimbriated Escherichia coli due to structural differences in fimH genes

Type 1 fimbriae are heteropolymeric surface organelles responsible for the D-mannose-sensitive (MS) adhesion of Escherichia coli. We recently reported that variation of receptor specificity of type 1 fimbriae can result solely from minor alterations in the structure of the gene for the FimH adhesin subunit. To further study the relationship between allelic variation of the fimH gene and adhesive properties of type 1 fimbriae, the fimH genes from five additional strains were cloned and used to complement the FimH deletion in E. coli KB18. When the parental and recombinant strains were tested for adhesion to immobilized mannan, a wide quantitative range in the ability of bacteria to adhere was noted. The differences in adhesion do not appear to be due to differences in the levels of fimbriation or relative levels of incorporation of FimH, because these parameters were similar in low-adhesion and high-adhesion strains. The nucleotide sequence for each of the fimH genes was determined. Analysis of deduced FimH sequences allowed identification of two sequence homology groups, based on the presence of Asn-70 and Ser-78 or Ser-70 and Asn-78 residues. The consensus sequences for each group conferred very low adhesion activity, and this low-adhesion phenotype predominated among a group of 43 fecal isolates. Strains isolated from a different host niche, the urinary tract, expressed type 1 fimbriae that conferred an increased level of adhesion. The results presented here strongly suggest that the quantitative variations in MS adhesion are due primarily to structural differences in the FimH adhesin. The observed differences in MS adhesion among populations of E. coli isolated from different host niches call attention to the possibility that phenotypic variants of FimH may play a functional role in populations dynamics.
Dynamics of Compartmented and Reticulate Food Webs in Relation to Energetic Flows

Using simple food webs, we address how the interactions of food web structure and energetic flows influence dynamics. We examine the effect of food web topologies with equivalent energetics (i.e., trophic interactions are equivalent at each trophic level), following which we vary energetic flows to include weak and strong interactions or nonequivalent energetics. In contrast to some work (Pimm 1979), we find that compartmented webs are more stable than reticulate webs. However, we find that nonequivalent energetics can stabilize previously unstable reticulate structures. It is not only weak flows that can be stabilizing but also the arrangement of the flows that emphasizes stabilizing mechanisms. We find that the main stabilizing mechanism is asynchrony, where structures and energetic arrangements that decrease synchrony such as internal segregation or competition will stabilize dynamics. Since compartments allow prey dynamics to behave somewhat independently, compartmentation readily promotes stability. In addition, these results can be scaled from simple food webs to more complex webs with many interacting subsystems so that linking weak subsystems to strong ones can stabilize dynamics. We show that food web dynamics are determined not only by topology but also the arrangement of weak and strong energetic flows.
Snake: A Stochastic Proximal Gradient Algorithm for Regularized Problems Over Large Graphs

A regularized optimization problem over a large unstructured graph is studied, where the regularization term is tied to the graph geometry. Typical regularization examples include the total variation and the Laplacian regularizations over the graph. When the graph is a simple path without loops, efficient off-the-shelf algorithms can be used. However, when the graph is large and unstructured, such algorithms cannot be used directly. In this paper, an algorithm, referred to as “Snake,” is proposed to solve such regularized problems over general graphs. The algorithm consists in properly selecting random simple paths in the graph and performing the proximal gradient algorithm over these simple paths. This algorithm is an instance of a new general stochastic proximal gradient algorithm, whose convergence is proven. Applications to trend filtering and graph inpainting are provided among others. Numerical experiments are conducted over large graphs.
In vitro efficacy of 75 essential oils against Aspergillus niger

Aspergillus niger is an opportunistic human pathogen and a strong air pollutant. A study was conducted with 75 different essential oils for the inhibition of hyphal growth and spore formation in Aspergillus niger. Cinnamomum zeylanicum (bark), Cinnamomum zeylanicum (leaf), Cinnamomum cassia, Syzygium aromaticum and Cymbopogon citratus were the top five essential oils which demonstrated marked inhibitory effect against hyphal growth and spore formation of A. niger. The chemical composition of these five most active essential oils was investigated by gas chromatography–mass spectra (GC–MS). Most of the other essential oils were found challenging to combat A. niger, suggesting their use as strong aroma therapeutic agents.
Intracerebral hemorrhage and death after envenoming by the jellyfish Carukia barnesi

Introduction. Irukandji syndrome is because of envenoming by a number of small jellyfish. It results in a delayed onset of generalized pain, sweating hypertension, and tachycardia. There is no antivenom. Case report. A 44-year-old healthy male was stung while swimming in NE Australia. He rapidly developed Irukandji syndrome. He had a rapid deterioration in conscious level because of an intracerebral hemorrhage. He developed left ventricular failure with an elevated troponin (34 mcg/L, N < 0.4) requiring inotropic support. He progressed to brain death and died on day 13 poststing. Nematocysts recovered from the patient skin were consistent with a large Carukia barnesi. Discussion. This is the first case of a death because of Irukandji syndrome where the jellyfish Carukia barnesi has been demonstrated to the causative creature.
Depressive symptoms among patients with acute myocardial infarction. Relationship with revascularization therapy

BACKGROUND Persistence of depressive symptoms after MI (myocardial infarction) is associated with adverse outcome. The relationship between depression and Invasive Revascularization Therapy (IRT) is not yet fully understood. The aim of the study was to evaluate the persistence of depressive symptoms after MI, and its relationship with social support, anxiety and IRT Methods 45 patients were prospectively evaluated at admission to hospital with a diagnosis of MI (Killip I and II), and at follow up after 3 months post discharge. All patients completed the Beck Depression Inventory (BDI), The Zung Anxiety Inventory (ASI), and the MOS social support survey. Depressive symptoms were considered to be present if the BDI score was >10. IRT were registered: 64.4% underwent IRT, 11.1% revascularization surgery, 53.3% coronary angioplasty. Results 87% were men, age 58 ± 11, 37% hypertensive, 15% diabetic, and 44% smokers. 44.4% scored> 10 in the BDI at baseline assessment and 26.5% at 3 months follow-up (p At baseline BDI score for IRT patients was 10,2 ± 5,1 and for no IRT patients 9,1 ± 4,4 (p=0.2). BDI score at 3 months follow up was 9,9 ± 5,6 for IRT patients and 4,1 ± 2,5 for no IRT patients (p Scores in the BDI were significantly correlated to anxiety (r=0.531, p DISCUSSION Depressive symptoms were frequent after MI, and decreased at follow up. However, patients who received IRT remained depressed at 3 months. The IRT group might represent a more vulnerable group with regards to the interaction between depression and cardiovascular outcomes.
Photoprotection of PSI by Far-Red Light Against the Fluctuating Light-Induced Photoinhibition in Arabidopsis thaliana and Field-Grown Plants

It has been reported that PSI photoinhibition is induced even in wild-type plants of Arabidopsis thaliana, rice and other species by exposure of leaves to fluctuating light (FL) for a few hours. Because plants are exposed to FL in nature, they must possess protective mechanisms against the FL-induced photodamage. Here, using A. thaliana grown at various irradiances, we examined PSI photoprotection by far-red (FR) light at intensities comparable with those observed in nature. Dark-treated leaves were illuminated by red FL alternating high/low light at 1,200/30 [REPLACEMENT CHARACTER]mol m−2 s−1 for 800 ms/10 s. By this FL treatment without FR light for 120 min, the level of photo-oxidizable P700 was decreased by 30% even in the plants grown at high irradiances. The addition of continuous FR light during the FL suppressed this damage almost completely. With FR light, P700 was kept in a more oxidized state in both low- and high-light phases. The protective effect of FR light was diminished more in mutants of the NADH dehydrogenase-like complex (NDH)-mediated cyclic electron flow around PSI (CEF-PSI) than in the PGR5 (proton gradient regulation 5)-mediated CEF-PSI, indicating that the NDH-mediated CEF-PSI would be a major contributor to PSI photoprotection in the presence of FR light. We also confirmed that PSI photoinhibition decreased with the increase in growth irradiance in A. thaliana and field-grown plants, and that this PSI photodamage was largely suppressed by addition of FR light. These results clearly indicate that the most effective PSI protection is realized in the presence of FR light.
Synovial fluid antigen‐presenting cells unmask peripheral blood T cell responses to bacterial antigens in inflammatory arthritis

We and others have previously shown that synovial fluid (SF) mononuclear cells (MC) from patients with both reactive arthritis and other inflammatory arthritides proliferate in vitro in response to bacteria clinically associated with the triggering of reactive arthritis. In all cases, such SFMC responses are greater than the corresponding peripheral blood (PB) MC responses, often markedly so, and the mechanism for this is unclear. We have investigated this phenomenon by comparing the relative abilities of irradiated non‐T cells derived from PB and SF to support autologous T cell responses to ReA‐associated bacteria. Seven patients whose SFMC had been shown previously to respond to bacteria were studied. We demonstrate antigen‐specific responses of PB T cells to bacteria in the presence of SF non‐T cells which are in marked contrast to the minimal responses of either unfractionated PBMC or PB T cells reconstituted with PB non‐T cells. We also show that PB, but not SF T cells respond strongly to autologous SF non‐T cells in the absence of antigen or mitogen. These findings demonstrate that SF antigen‐presenting cells (APC) are potent activators of PB T cells. We conclude that the contrasting responses of SFMC and PBMC to bacterial antigens may be accounted for at least in part by an enhanced ability of SF APC to support T cell proliferative responses.
Simulation in 3D integration and TSV

The development of 3D-silicon integrated circuits is an increasing demand especially regarding to advanced 3D-packages and high performance applications, with the intend to miniaturize and to reduce costs. Through-silicon-vias (TSV), interconnects and landing pads have a strong mismatch in proportions. Due to high temperature as well as high applied currents, the reliability of the systems and components is affected by thermal and thermal-electrical loads. The induced stress leads to degradation effects like electro- and thermomigration (EM, TM). Mismatch in coefficient of thermal expansion (CTE) are causing mechanical induced stress during the manufacturing process. This can lead to failure mechanisms like delamination and cracking around the TSV or in the ICs.