Miracle-dz/UniFAR-FTUs huggingface dataset:
At risk for anxiety: I. Psychopathology in the offspring of anxious parents.

OBJECTIVE AND METHOD Children of parents with anxiety disorders, depressive disorders, mixed anxiety/depressive disorders, and no psychiatric disorder were assessed with semistructured interviews to determine rates of overall psychopathology and to determine specifically the presence of anxiety disorders. RESULTS Children of the three "high-risk" groups were significantly more likely to have a diagnosable disorder (including anxiety disorders) than offspring of normal parents, but there were no differences among the children from the three parental diagnostic groups. However, when examined specifically for anxiety disorders, offspring of anxious parents were significantly more likely to have only anxiety disorders. Offspring of depressed or mixed anxious/depressed parents had a broader range of disorders and more comorbid disorders. Family socioeconomic status was related to the probability that a child would have a disorder. CONCLUSIONS Anxiety disorders are common among offspring of anxious and depressed parents. However, when a parent has depression, children exhibit a broader range of psychopathology than when a parent has an anxiety disorder alone.
Self-presentation in Online Professional Networks: Men's Higher and Women's Lower Facial Prominence in Self-created Profile Images

Men are presented with higher facial prominence than women in the media, a phenomenon that is called face-ism. In naturalistic settings, face-ism effects could be driven by gender biases of photographers and/or by gender differences in self-presentation. The present research is the first to investigate whether women and men themselves create this different facial prominence. In a controlled laboratory study, 61 participants prepared a picture of themselves from a half-body photograph, allegedly to be uploaded to their profile for an online professional network. As expected, men cropped their photos with higher facial prominence than women did. However, women and men did not differ in the self-presentational motivations, goals, strategies, and personality variables under investigation, so that the observed face-ism effect could not be explained with these variables. Generally, the higher participants' physical appearance self-esteem, the higher was their self-created facial prominence.
Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas

Cyclin E is a critical G1-S cell cycle regulator aberrantly expressed in bronchial premalignancy and lung cancer. Cyclin E expression negatively affects lung cancer prognosis. Its role in lung carcinogenesis was explored. Retroviral cyclin E transduction promoted pulmonary epithelial cell growth, and small interfering RNA targeting of cyclin E repressed this growth. Murine transgenic lines were engineered to mimic aberrant cyclin E expression in the lung. Wild-type and proteasome degradation-resistant human cyclin E transgenic lines were independently driven by the human surfactant C (SP-C) promoter. Chromosome instability (CIN), pulmonary dysplasia, sonic hedgehog (Shh) pathway activation, adenocarcinomas, and metastases occurred. Notably, high expression of degradation-resistant cyclin E frequently caused dysplasia and multiple lung adenocarcinomas. Thus, recapitulation of aberrant cyclin E expression as seen in human premalignant and malignant lung lesions reproduces in the mouse frequent features of lung carcinogenesis, including CIN, Shh pathway activation, dysplasia, single or multiple lung cancers, or presence of metastases. This article reports unique mouse lung cancer models that replicate many carcinogenic changes found in patients. These models provide insights into the carcinogenesis process and implicate cyclin E as a therapeutic target in the lung.
A "slow" homotetrameric kinesin-related motor protein purified from Drosophila embryos.

Pan-kinesin peptide antibodies (Cole, D. G., Cande, W. Z., Baskin, R. J., Skoufias, D. A., Hogan, C. J., and Scholey, J. M. (1992) J. Cell Sci. 101, 291-301; Sawin, K. E. , Mitchinson, T. J., and Wordeman, L. G. (1992) J. Cell Sci. 101, 303-313) were used to identify and isolate kinesin-related proteins (KRPs) from Drosophila melanogaster embryonic cytosol. These KRPs cosedimented with microtubules (MTs) polymerized from cytosol treated with AMP-PNP (adenyl-5'-yl imidodiphosphate), and one of them, KRP130, was further purified from ATP eluates of the embryonic MTs. Purified KRP130 behaves as a homotetrameric complex composed of four 130-kDa polypeptide subunits which displays a "slow" plus-end directed motor activity capable of moving single MTs at 0.04 +/- 0.01 microns/s. The 130-kDa subunit of KRP130 was tested for reactivity with monoclonal and polyclonal antibodies that are specific for various members of the kinesin superfamily. Results indicate that the KRP130 subunit is related to Xenopus Eg5 (Sawin, K. E., Le Guellec, K. L., Philippe, M., Mitchinson, T. J. (1992) Nature 359, 540-543), a member of the BimC subfamily of kinesins. Therefore, KRP130 appears to be the first Drosophila KRP, and the first member of the BimC subfamily in any organism, to be purified from native tissue as a multimeric motor complex.
New Asian American Voters: Political Incorporation and Participation in 2016

In 2016, Asian Americans represented the fastest growing racial minority group in the United States largely due to the flow of new immigration. As a result, Asian Americans are poised to be the next major bloc of new voters in the electorate. Yet, as a largely new immigrant group, institutional barriers—in particular, naturalization and registration—are important factors which need to be more thoroughly taken into account when explaining Asian American participation patterns. In this article, we show how scholars can adopt a different strategy of analysis that recognizes both institutional barriers to political participation through immigrant status and variation across national origin group. We argue that structural impediments to participation and national origin differences have not been fully accounted for in previous explanations of Asian American political participation. Our analysis shows that when Asian Americans are disaggregated by incorporation status (being registered to vote, eligible but not registered to vote, or noncitizen), we gain new insights about the factors that predict political participation. The findings from an analysis of 2016 election data feature the unique behaviors of Filipinos, Asian Indians, and the Vietnamese and highlight that second-generation Asian Americans are not necessarily more participatory than their immigrant counterparts.
Complementary D Flip-Flops Based on Inkjet Printed Single-Walled Carbon Nanotubes and Zinc Tin Oxide

We report clocked sequential complementary circuits that operate at 5 V in which the active semiconductors are deposited by inkjet printing. The p-channel thin-film transistors (TFTs) employ a network of predominantly semiconducting (>98%) single-walled carbon nanotubes and the n-channel TFTs employ amorphous zinc tin oxide formed from a printed precursor solution. The gate insulator material in both cases is zirconium oxide, deposited from solution. Edge triggered D flip-flops operate at clock speeds of 2.5 kHz. Our results suggest that this materials combination is promising for use in printed electronics.
Nasal Lymphoid Tissue (NALT) as a Mucosal Immune Inductive Site

Intranasal (i.n.) immunization is a very effective route for inducing mucosal immunity, but the cellular mechanism responsible for regulating and disseminating these responses is not fully understood. The authors studied the role of nasal lymphoid tissue (NALT) as a mucosal inductive site by using highly purified NALT cells obtained by a new method of mechanical isolation. The NALT cells, like Peyer's patch (PP) cells, were smaller in size and less granular than lymphocytes from salivary glands (SG) and small intestinal lamina propria (LP). The NALT cells isolated from i.n. immunized mice contained antigen‐specific antibody‐secreting cells (ASC) predominantly of immunoglobulin (Ig)A isotype, similar to those also recovered from salivary glands in a time course study. However, the higher proportion of smaller sized spots formed by NALT cells in ELISPOT assays suggested that these cells were less differentiated precursors of those found in salivary glands. This was supported by the fact that after i.n. immunization, IgA ASC appeared in NALT, as well as in mucosal effector sites SG and LP, but none or very few in another mucosal inductive site, PP. In contrast, after intragastric (i.g.) immunization, IgA ASC were detected in PP, along with the SG and LP, but none or very few in NALT. Furthermore, after i.n. immunization, lymphocytes from NALT but not PP proliferated in response to the specific antigen in culture. These findings imply that NALT served as an inductive site for IgA antibody responses at mucosal effector sites.
In Situ and Laboratory Assessment of Heart Rate in a Mediterranean Limpet Using a Noninvasive Technique

Heart rate of the Mediterranean limpet Patella caerulea L. was investigated on the natural shore and in the laboratory by using a technique based on infrared phototransducers. Field recording occurred in the Gulf of Trieste (northern Adriatic) during March and June 1997. A consistent dependence of heart rate on temperature was observed in limpets both when submerged and when exposed to air in the two periods, but thermal acclimation was evident. During spontaneous activity at high tide, heart rate increased 1.5–1.7 times the values observed during resting in water at corresponding temperatures. The dependence of heart rate on temperature (10°, 16°, and 22°C) and size (wet weight <1.25 and >1.30 g) in submerged limpets from different populations (northern Adriatic and Tyrrhenian) was tested in the laboratory by adopting a factorial design. The results showed a marked effect of temperature, body weight, and their interaction, independent from the site of origin. Smaller limpets showed a linear increase of heart rate in the whole range of temperature tests, while in the larger ones the increase between 10° and 16°C was greater than between 16° and 22°C. Heart rate decreased with increasing body size at control (16°C) and high (22°C) temperature, while at lower temperature (10°C) no effect of body size was evident. When removed from their home scar, limpets increased heart rate to about 1.5 times the reference value. Finally, correlation of oxygen consumption with heart rate of submerged limpets maintained at a different temperature (10°–22°C) was statistically significant.
Real-time Camera Pose Estimation using Correspondences with High Outlier Ratios - Solving the Perspective n-Point Problem using Prior Probability

We present PPnP, an algorithm capable of estimating a robust camera pose in real-time, even if being provided with large sets of correspondences containing high ratios of outliers. For these situations, standard pose estimation algorithms using RANSAC are often unable to provide a solution or at least not in the required time frame. PPnP is provided with a probability distribution function which describes all valid possible camera pose estimates. By checking the correspondences for being compatible with the prior probability, it can be decided effectively at a very early stage, which correspondences can be treated as outliers. This allows a considerably more effective selection of hypothetical inliers than in RANSAC. Although PPnP is based on a technique called BlindPnP which is not intended for real-time computing, a number of changes in PPnP allows to estimate a camera pose with the same high quality as BlindPnP while being considerably faster.
Brain injury biomarkers in the setting of cardiac surgery: Still a world to explore

Abstract Background: Brain injury is an important, potentially devastating, complication in cardiac surgery. A significant number of patients suffer perioperative complications involving the central nervous system. Clinical manifestations of brain injury are associated with significantly increased mortality, morbidity and health resource utilization. Serum biomarkers have been studied in cardiac surgery to measure the degree and incidence of brain injury and to improve patient management. Methods: All relevant studies were identified by computerized searches of PubMed using the following Medical Subject Headings and keywords term: biomarker, cardiac surgery, brain injury and neurological complication. Results: The biomarkers that appear to be better indicators of brain injury severity in cardiac surgery and its consequences are S100B protein, neuron-specific enolase, glial fibrillary acidic protein, tau protein, matrix metalloproteinase-9, ubiquitin C terminal hydroxylase-L1 and neurofilaments. Conclusions: These biomarkers, independently of clinical and radiological findings, show global cerebral situation at the cellular level and the degree of brain dysfunction. However, up to date, there is no biomarker entirely suitable for the detection of brain injury after cardiac surgery.
A 24 GHz CMOS miniaturized phase-invertible variable attenuator incorporating edge-coupled synthetic transmission lines

This paper presents a CMOS miniaturized phase-invertible variable attenuator (PIVA) at K-band. The PIVA only consists of one 3-dB transmission line (TL) based directional coupler, two NMOS transistors, and simple matching network. The technique of complex impedance matching is proposed to improve the precision of the phase reversal, and reduce the phase shifting of the PIVA. Furthermore, the 3-dB coupler, which is realized by the edge-coupled synthetic transmission lines, so-called the complementary-conducting strip coupled lines (CCS CLs), is applied to PIVA design for the circuit miniaturization. The presented attenuator design is analyzed and fabricated by using standard 0.18 µm 1P6M CMOS technology. The prototype, which has only a chip size of 242 µm × 246 µm excluding the contacting pads, are experimentally characterized through the on-wafer measurements. The measured phase reversal is 181.4 degree, nearly approaching to the ideal state. From 20 to 28 GHz, the measured attenuation dynamic range is more than 20 dB with a phase shifting less than 8.8 degree. The input and output return losses are lower than −10.2 and −11 dB, respectively.
Culling patterns in selected Minnesota swine breeding herds.

This investigation was conducted to study culling patterns in swine breeding herds. Data were obtained from 89 Minnesota swine breeding herds and included 5918 sows and 1324 gilts for a total of 7242 culled femaled. Each producer was involved for 12 consecutive months. They were asked to record every female that was removed from the herd, the reason for its culling and its parity. The annual culling rate for the sample averaged 50%, but varied considerably between herds ranging from 15% to 85%. Culled females had produced an average of 3.77 litters. Half of the females culled did not produce more than three litters. Reproductive failure accounted for 32% of all removals. The average parity of the females culled in that category was only 2.37: almost 33% were gilts. Failure to conceive represented 75% of all females culled for reproductive failure. Proportionally, culling as a result of anestrus was higher in gilts. It accounted for 33% of all gilts culled for reproductive failure which was twice as much as for sows. Inadequate performance accounted for 17% of all removals. These sows had produced an average of 5.11 litters. These results indicated that few animals were culled on the basis of first litter performance. Old age comprised 14% of all removals and the average parity at culling for this category was 7.11. Death accounted for 12% and the average parity for these females was 3.40. Locomotor problems and peripartum problems were the cause of 28% and 23% of all deaths, respectively. (ABSTRACT TRUNCATED AT 250 WORDS)
An Adaptive Learning with Gamification & Conversational UIs: The Rise of CiboPoliBot

Gamification in the era of chatbots is a novel way to engage users with the chatbot application. When developing a gamified chatbot system, there are factors related to user types (ages, gender and others) that we should consider to effectively integrate the game elements into the chatbot while targeting the right audience. In this study, we discuss the development of an educational chatbot game 'CiboPoli', that's specialised in teaching children about healthy lifestyle through an interactive social game environment. The presented game is based on a paper prototype that we developed to teach primary school students about healthy diet and food waste management. The current approach will be more engaging and pose AI capabilities. This is still a work in progress and we plan to improve its design by incorporating additional components, such as dialog management module, user-specific knowledge module or machine learning module. Future work will be devoted to integrating machine learning to automatically identify learners emotions and provide personalised suggestions. Moreover, we tested the initial prototype with school students and found that it outperforms the paper version. Future work will focus on applying it to other domains and demographics.
Neurotoxic action of kainic acid in the isolated toad and goldfish retina: II. Mechanism of action

The specificity and mechanism of the neurotoxic action of kainic acid (KA) was investigated by histological methods in the isolated retina of toads and goldfish. Particular attention was paid to the earliest and most sensitive response to KA in the outer plexiform layer (OPL). Of 21 compounds tested as potential mimics of KA neurotoxicity in the OPL, only the enantiomers of glutamate and aspartate mimicked KA, inducing a low‐level neurotoxic effect at concentrations 5,000–10,000‐fold higher than concentrations of KA giving comparable effects. Further, of 22 compounds tested as potential blockers of KA neurotoxicity in the OPL, only D‐γ‐glutamylglycine, D,L‐α‐amino pimelic acid, sodium pentobarbital, D,L‐α‐amino adipic acid, L‐glutamate, and L‐aspartate blocked KA neurotoxicity (IC50 values of 0.1, 0.3, 0.3, 2, 5, and 15 mM, respectively). In ionic substitution experiments, KA‐induced vacuolization was found to require sodium and chloride ions but not calcium ions in the extracellular medium.
Exogenous Hormones in the Aetiology of Cancer in Women

Both animal experimental work and epidemiological, clinical, and laboratory research on the effects of endogenous hormones in the human have made it clear that some influence of administered female sex hormones on the risk of certain cancers would be anticipated, and this has turned out to be the case. This review focuses on the administration of hormones during pregnancy, around the time of the menopause, and to prevent pregnancy. In the daughters who were exposed in utero to stilbestrol during the 1950s and 1960s, the most important effect is the development of clear cell adenocarcinoma of the vagina or cervix. Few cases of this disease have been reported before puberty, but the cumulative risk thereafter up to the age of 24 years is estimated to be between 1.4 and 4/10,000 exposed. Much less attention has been paid to the mothers who actually took the stilbestrol than to their daughters, but the published data fail to provide any convincing evidence of an increased risk of either breast or reporductive cancer among them. Regarding the administration of hormones around the time of menopause, it is well established that unopposed estrogen therapy in menopausal women can cause endometrial cancer. This has been demonstrated in a large number of case control studies reported since 1975. Most of these studies were conducted in the US and most concern the drup Premarin (conjugated equine estrogens). Some cohort studies also have been reported, and they largely support the results of the case control studies. There is now little doubt that combined oral contraceptives (OCs) protect against both epithelial ovarian cancer and endometrial cancer. Preliminary findings in the major cohort studies concerned with the longterm effects of OC use also are encouraging. A series of large case control studies conducted during the 1970s showed clearly that there is no general association between oral contraceptive use and breast cancer risk, but these large studies included few women with appreciable OC use at an early age and accordingly the publication by Pike et al. in 1981 caused much concern. Pike's study involved 163 women in Los Angeles County in whom breast cancer has been diagnosed at age 32 or less, together with a like number of neighborhood controls. Vessey et al. (1982) and the Centers for Disease control subsequently published results which did not support the California findings. Preliminary results from a new case control study conducted in Oxford and in London since 1980 suggest an increased risk of breast cancer in young women who have prolonged OC use before 1st pregnancy. The situation is very confusing and it may be some time before there is a conclusive answer. In a large cohort study conducted in Los Angeles, rates of progression from cervical dysplasia to carcinoma in situ were much higher in women using Ovulen than in women using IUDs.
Multi-Factor Portfolios: A New Factor? Limits of the Static Approach

We assess the value added of a multifactor portfolio from a performance-agnostic point of view. First we introduce a broad general definition of factor, that encompasses usual factors like Size or Value, and then we prove that static long–short multifactor strategies (as the equal weighting of factors) are indeed factors according to our definition. This result is new in the literature and states that, by investing in a long–short static multifactor strategy, one is indeed investing into a new (synthetic) factor. Finally we test the strength of such a synthetic factor compared to each single factor by looking at its predictive power. We empirically test the equal-weighting of Value, Size, Momentum and Low Volatility in the US and Europe. Our conclusion is very clear in both regions: the equal-weighting of these four standard factors is a synthetic factor that has no predictive power on stocks’ return, while each of the factors shows clear ability to distinguish among stocks. In other words, the measure that underlies this equal-weighting of factors has zero predictive power on cross-sectional differences in stocks’ returns.
Liver transplantation from controlled non–heart-beating donors: an increased incidence of biliary complications

Background. Hepatic allografts from non–heart-beating donors (NHBD) have been cited as a means to expand the supply of donor livers. Concern exists that donor warm ischemic time in addition to subsequent cold ischemia-reperfusion injury may result in damage to sensitive cell populations within the liver. Because the biliary epithelium is sensitive to ischemia-reperfusion injury, the authors surmised that an increased incidence of biliary complications might occur among recipients of an NHBD allograft. Methods. This study was a retrospective evaluation of NHBD recipients compared to a group of heart-beating donor (HBD) recipients from a single institution. Results. Fifteen patients received a hepatic allograft from a controlled NHBD donor. NHBD and HBD (n=221) graft survival did not differ at 1 (71.8% vs. 85.4%, P =0.23) or 3 years (71.8% vs. 73.9%, P =0.68). Patient survival at 1 (79% vs. 90.9%, P =0.16) and 3 years (79.0% vs. 77.7%, P =0.8) was also similar. Major biliary complications occurred in five (33.3%) NHBD recipients; 66.6% of the NHBD biliary complications consisted of intrahepatic strictures versus 19.2% among HBD recipients (P <0.01). Major biliary complications in the NHBD recipients resulted in multiple interventional procedures, retransplantation, and death. Conclusions. Donor warm ischemic time may predispose hepatic allografts to an increased incidence of ischemic type strictures. Although graft and patient survival was similar to a cohort of HBD recipients, caution is urged with the use of these organs.