Miracle-dz/UniFAR-FTUs huggingface dataset:
Daily support and negative control during a quit attempt in single-smoking couples.

OBJECTIVE Research has shown a beneficial influence of partner support on smoking cessation. Previous studies mainly focused on support and neglected negative behaviors. Less is known about differences in support perceptions between partners. This study aimed to examine how supportive as well as negative control behaviors relate to smoking and relationship satisfaction in single-smoking couples during a quit attempt. METHOD Smokers and their nonsmoking partners (n = 170 cohabiting couples) participated in an intensive longitudinal study over 21 days with end-of-day diaries. A dyadic score model was used, emphasizing couple levels and differences for the explanatory variables (i.e., support and negative control) and the outcome variables (smoking [for smokers only]; relationship satisfaction). RESULTS Smokers whose partner showed more supportive and less negative control behavior had a lower probability of smoking, and both partners had higher relationship satisfaction. On days with more supportive and less negative control behavior than usual, smokers had a lower probability of smoking and both partners had higher relationship satisfaction. For smokers who reported more support than their partner reported providing, the couples' relationship satisfaction was higher and the smokers' relationship satisfaction was higher than their partners'. Differences between received and provided support/control at the between-couple and daily level were unrelated to smoking. CONCLUSIONS Support seems important during a quit attempt as it was related to a lower probability of smoking and higher relationship satisfaction in couples, while negative control behaviors should be avoided as they were associated with higher probability of smoking and lower relationship satisfaction. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
Clinical Significance of Receptor-Interacting Protein 3 and Parkin, Essential Molecules for Necroptosis, in Breast Cancer

Purpose Receptor-interacting protein 3 (RIP3) is the main initiator of necroptosis. Parkin prevents the formation of the RIP1–RIP3 complex by promoting polyubiquitination of RIP3. However, the mechanism by which necroptosis affects the clinical features of breast cancer and prognosis is not known. Here, we aimed to study the effect of necroptosis on the clinical features and prognosis of breast cancer by assessing the expression of RIP3 and Parkin. Methods Tissue microarrays (TMAs) were constructed from 257 cases of breast cancer. Immunohistochemistry was performed on 4-μm tissue sections from each TMA block. The χ2 test, Kaplan-Meier survival analysis with log-rank test, and Cox regression proportional hazard model were used for statistical analysis. Results Low RIP3 expression resulted in a large tumor size and high nuclear grade. Low RIP3 expression was correlated with human epidermal growth factor receptor 2 positivity, short overall survival (OS), and short disease-free survival (DFS). The triple negative breast cancer group with low RIP3 expression and lymph node (LN) positive group with low RIP3 expression had the shortest OS. High Parkin expression was associated with high histological grade, estrogen and/or progesterone receptor negativity, and lymphatic emboli, but was not correlated with OS and DFS. OS was correlated with LN metastasis and RIP3 loss and DFS with large tumor size, LN metastasis, and RIP3 loss. Conclusion Low RIP3 and high Parkin expression are associated with aggressive clinical features in breast cancer. RIP3, a molecular marker of necroptosis, is an independent factor associated with survival in breast cancer. Further in-depth studies are needed to investigate the role of necroptosis in breast cancer development, metastasis, and treatment in the future.
Risk of Conversion to Arthroplasty After Hip Arthroscopy: Validation of a Published Risk Score Using an Independent, Prospectively Collected Database

Background: Hip arthroscopy is rapidly advancing and increasingly commonly performed. The most common surgery after arthroscopy is total hip arthroplasty (THA), which unfortunately occurs within 2 years of arthroscopy in up to 10% of patients. Predictive models for conversion to THA, such as that proposed by Redmond et al, have potentially substantial value in perioperative counseling and decreasing early arthroscopy failures; however, these models need to be externally validated to demonstrate broad applicability. Purpose: To utilize an independent, prospectively collected database to externally validate a previously published risk calculator by determining its accuracy in predicting conversion of hip arthroscopy to THA at a minimum 2-year follow-up. Study Design: Cohort study (diagnosis); Level of evidence, 1. Methods: Hip arthroscopies performed at a single center between November 2015 and March 2017 were reviewed. Patients were assessed pre- and intraoperatively for components of the THA risk score studied—namely, age, modified Harris Hip Score, lateral center-edge angle, revision procedure, femoral version, and femoral and acetabular Outerbridge scores—and followed for a minimum of 2 years. Conversion to THA was determined along with the risk score’s receiver operating characteristic (ROC) curve and Brier score calibration characteristics. Results: A total of 187 patients (43 men, 144 women, mean age, 36.0 ± 12.4 years) underwent hip arthroscopy and were followed for a mean of 2.9 ± 0.85 years (range, 2.0-5.5 years), with 13 patients (7%) converting to THA at a mean of 1.6 ± 0.9 years. Patients who converted to THA had a mean predicted arthroplasty risk of 22.6% ± 12.0%, compared with patients who remained arthroplasty-free with a predicted risk of 4.6% ± 5.3% (P < .01). The Brier score for the calculator was 0.04 (P = .53), which was not statistically different from ideal calibration, and the calculator demonstrated a satisfactory area under the curve of 0.894 (P < .001). Conclusion: This external validation study supported our hypothesis in that the THA risk score described by Redmond et al was found to accurately predict which patients undergoing hip arthroscopy were at risk for converting to subsequent arthroplasty, with satisfactory discriminatory, ROC curve, and Brier score calibration characteristics. These findings are important in that they provide surgeons with validated tools to identify the patients at greatest risk for failure after hip arthroscopy and assist in perioperative counseling and decision making.
Determination of absolute photoionization cross sections for vinyl and propargyl radicals

Photofragment translational spectroscopy experiments employing tunable vacuum ultraviolet photoionization yielded absolute photoionization cross sections for vinyl and propargyl radicals at 10 eV of 11.1±2.2 and 8.3±1.6 Mb, respectively. From these values, the photoionization efficiency curves from 7.8–10.8 eV for these radicals were placed on an absolute scale.
Risk Factors for Longitudinal Resting Heart Rate and Its Associations With Cardiovascular Outcomes in the DCCT/EDIC Study

OBJECTIVE Individuals with diabetes have higher resting heart rate compared with those without, which may be predictive of long-term cardiovascular disease (CVD) risk. Using data from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study, we evaluated whether the beneficial effect of intensive versus conventional diabetes therapy on heart rate persisted, the factors mediating the differences in heart rate between treatment groups, and the effects of heart rate on future CVD risk. RESEARCH DESIGN AND METHODS Longitudinal changes in heart rate, from annual electrocardiograms over 22 years of EDIC follow-up, were evaluated in 1,402 participants with type 1 diabetes. Linear mixed models were used to assess the effect of DCCT treatment group on mean heart rate over time, and Cox proportional hazards models were used to estimate the effect of heart rate on CVD risk during DCCT/EDIC. RESULTS At DCCT closeout, 52% of participants were male and mean ± SD age was 33 ± 7 years, diabetes duration 12 ± 5 years, and HbA1c 7.4 ± 1.2% (intensive) and 9.1 ± 1.6% (conventional). Through EDIC, participants in the intensive group had significantly lower heart rate in comparison with the conventional group. While significant group differences in heart rate were fully attenuated by DCCT/EDIC mean HbA1c, higher heart rate predicted CVD and major adverse cardiovascular events independent of other risk factors. CONCLUSIONS After 22 years of follow-up, former intensive versus conventional therapy remained significantly associated with lower heart rate, consistent with the long-term beneficial effects of intensive therapy on CVD. DCCT treatment group effects on heart rate were explained by differences in DCCT/EDIC mean HbA1c.
How Important Are Quantum Mechanical Nuclear Motions in Enzyme Catalysis

The role of quantum mechanical nuclear motions in enzymatic reactions is examined by realistic simulations that take into account the fluctuations of an entire enzyme−substrate complex. This is done by using the quantized classical path (QCP) approach which is based on Feynman's path integral formulation. The calculations evaluate the quantum mechanical activation free energy and deuterium isotope effect for the proton transfer step in the catalytic reaction of carbonic anhydrase. The calculated and observed isotope effects are in very good agreement, thus demonstrating the potential of our approach in extracting mechanistic information. Furthermore, the value of the calculated quantum mechanical rate constant is in a good agreement with the corresponding observed value. This is significant since the evaluation of the ratio between the quantum mechanical rate constants of the reaction in the protein and in aqueous solution does not involve any adjustable parameter. The reliability of our calculations is b.
Current status of phthalocyanines in the photodynamic therapy of cancer

Photodynamic therapy is a binary treatment now accepted in clinic for various malignancies in several countries around the world. Phthalocyanine molecules are second-generation photosensitizers with enhanced photophysical and photochemical properties over those of porphyrins. They have been shown to be phototoxic against a number of cell types and tumor models. A great deal of research has been devoted to the elucidation of their mechanism of action and mode of cell death. The present paper reviews phthalocyanine pre-clinical anti-cancer research with emphasis on phthalocyanine induced apoptosis using a silicon phthalocyanine, Pc4. A brief summary of the latest clinical results using phthalocyanines is presented.
Arsenic trioxide in pediatric cancer – a case series and review of literature

Abstract Arsenic trioxide (ATO) has become an established component of treatment protocols for acute promyelocytic leukemia (APL) with excellent efficacy and no relevant sustained toxicity. Part of its action has been attributed to the inhibition of Hedgehog signaling (Hh) which enables a possible therapeutic approach as many pediatric tumor entities have been associated with increased Hh activity. We retrospectively analyzed 31 patients with refractory and relapsed pediatric cancer who were treated with ATO at the University Children’s Hospital of Tuebingen. Additionally a literature review on the clinical and preclinical use of ATO in pediatric cancer treatment was performed. ATO alone as well as combinations with other drugs have proven effective in vitro and in mouse models of various pediatric malignancies. However, only few data on the clinical use of ATO in pediatric patients besides APL exist. In our patient sample, ATO was overall well tolerated in the treatment of various pediatric cancers, even in combination with other cytostatic drugs. Due to distinct tumor entities, differently progressed disease stages and varying co-medication, no clear statement can be made regarding the efficacy of ATO treatment. However, patients with proven Hh activation in molecular tumor profiling surpassed all other patients, who received ATO in an experimental treatment setting, in terms of survival. As molecular profiling of tumors increases and enhanced Hh activity can be detected at an early stage, ATO might expand its clinical use to other pediatric malignancies beyond APL depending on further clinical studies.
Narrative review of the influence of high-intensity interval training on adolescents’ bone health: commentary and perspectives

Although several benefits have been associated to high-intensity interval training (HIIT), there is a lack of clarity on the HIIT effects in adolescents, especially on bone health outcomes. To address this gap, our research aimed to perform a systematic review, which focus on the influence of HIIT on adolescents’ bone health. Our search strategy was conducted on three databases (PubMed, SCOPUS, and Embase). For our review, we included articles with the following characteristics: (I) sample consisting of adolescents (10–19 years old), (II) HIIT interventions; and (III) assessment of bone health outcomes. Longitudinal and clinical trials studies with no language and year of publications restrictions were eligible to be included. A total of 63 eligible studies were identified. After removing the duplicates and screening the titles and abstracts, six articles remained to be read in full text. However, none of the articles met our criteria. Studies in which no article meets the eligibility criteria are also essential and need to be shared with the academic community because it may stimulate appropriate future investigations in this field. This lack in the review results highlights the need for further epidemiological research focusing on this topic, including high quality, large scale, and longitudinal studies, as well as randomized controlled trials to confirm or refute efficacy.
Analyzing the Effects of Methyl Esters Produced from Raw Soybean and Waste Frying Oil on Engine Performance and NOx Emission

Abstract In this study, biodiesel is produced from waste frying oil and raw soybean oil by using a transesterification method. The effects of waste frying and raw soybean methyl esters on engine performance and NOx emissions are investigated. By using waste frying and raw soybean methyl esters, a decrease in engine torque and power and an increase in specific fuel consumption due to low heating values of methyl esters are observed. Since the oxygen content of methyl esters affects NOx development, an increase in NOx emissions is also observed.
Interstage mortality in two‐stage elephant trunk surgery

Diffuse mega‐aorta is challenging. Prior studies have raised concerns regarding the safety of the open two‐stage elephant trunk (ET) approach for extensive thoracic aortic aneurysm (TAA), specifically in regard to interstage mortality. This study evaluates the safety of the two‐stage ET approach for management of extensive TAA.
Development of a New Generation of Gold Catalysts for Amine Oxidation

A new type of outstandingly active gold catalysts has been developed for the aerobic oxidation of amines to imines. The gold nanoparticles are generated in situ in an organic medium prior to the oxidation reaction. Various gold salts, preferably AuCl3 and HAuCl4⋅3 H2O, can be applied in the presence of nanoceria and the amine substrate acts as the reducing agent. The synergism between gold and ceria evacuated at 200 °C has a remarkable positive effect on the oxidation activity. The catalysts have been tested in the oxidation of dibenzylamine, N‐tert‐butylbenzylamine, and indoline. Apparently, the presence of organic and inorganic residue after the in situ catalyst preparation does not diminish the oxidation activity of gold. An alternative, less efficient route is the quantitative adsorption of [Au(PPh3)Cl] precursor onto ceria in an organic medium and the subsequent ex situ evolution of gold nanoparticles (ca. 5 nm) via calcination at 250–400 °C. This catalyst is still tenfold more active than conventional supported gold nanoparticles. In addition, it is free from impurities evolving during the in situ preparation and thus may find application in reactions other than amine oxidation.
Sleep pattern and staging in elite adolescent rugby players during the in-season competitive phase compared to an age matched non-athlete population

ABSTRACT Young athletes must contend with the constraints of elite sports on top of school commitments and the physiological processes associated with adolescence. This study assessed week and weekend sleep and schedule of activities in elite adolescent rugby players during the in-season competitive phase compared with age-matched non-athlete controls. 32 adolescents (GR: 16 elite rugby players, GC: 16 controls) from the same boarding school filled out a daily schedule of activities and a sleep diary, and wore a multichannel electroencephalogram for 14 days. They later filled out questionnaires on their sleep quality, sleepiness, and perceived stress. Both groups showed insufficient sleep duration during the week (<7 h). Only GC caught up on their sleep debt during the weekend (increased TIB, TST and time spent in REM sleep, all p < 0.001). Weekend TIB, TST and, N3 sleep remained similar to that for weekdays in GR. However, GR experienced lower sleep quality (decreased SE, increased WASO, all p < 0.01) and a decrease in REM sleep (p < 0.01). Schedules of activities showed an increase in time spent on overall activities during the weekend, mainly due to competition and sport-specific travel, which resulted in a decrease in sleep opportunity time compared with GC (p < 0.001). Δ sleep opportunity time (weekend-week) was associated with Δ TST (weekend-week), and Δ TST (weekend-week) was associated with sleepiness and perceived stress. Busy schedules during the competitive season decreased sleep opportunity time and prevented elite adolescent rugby players from catching up on their sleep at weekends. HIGHLIGHTS Adolescent rugby players have insufficient sleep during both week and weekend of the in-season competitive phase Congested schedule prevented elite adolescent rugby players from catching up on their sleep at weekends. Sleep considerations are necessary when planning the weekend sporting schedules
Complementary feeding practices and associated factors among children aged 6–23 months in Pakistan

Premature mortality and undernutrition rates in Pakistan are among the highest in the world. Inadequate infant and young child feeding are the major causes of premature mortality and undernutrition. Yet, very little is known about the determinants of complementary feeding practices in Pakistan. Therefore, this study aims to identify the determinants of inadequate complementary feeding practices among children aged 6 to 23 months in Pakistan by using the latest nationally representative data from the Pakistan Demographic and Health Survey (2017–18). The results show that only 12% of children consume a minimum acceptable diet, 21% achieve minimum dietary diversity, and 38% reach minimum meal frequency. Multivariate regression analysis shows that child age, child weight at birth, mother’s access to newspapers/magazines at the individual level, wealth at the household level, and prenatal visits at the community level are significant predictors of complementary feeding practices among children aged 6–23 months in Pakistan. These findings show that, in addition to poverty alleviation, raising awareness through health practitioners, increasing access to media, and expanding access to child and maternal healthcare can improve complementary feeding practices in Pakistan. This consequently reduces premature mortality and undernutrition.
Combined action of gamma radiation and exposure to copper ions on Lemna minor L

Abstract Purpose Under natural conditions, the reaction of living organisms to the action of acute gamma radiation depends on other stressors, including heavy metals. The aim of this work was to study changes in morphometric parameters, the content of photoassimilation pigments and the level of oxidative stress in irradiated duckweed at various copper concentrations in the culture medium. Materials and methods As a model organism, we used Lemna minor L. Duckweed was exposed to acute γ-radiation at doses of 18, 42, 63 Gy. After irradiation, the plants were transferred into a medium containing 3, 5, 6.3 μmol/L Cu. On the 4th day of exposure, the levels of chlorophyll, carotenoids, malondialdehyde (MDA) were measured; after 7 days, the specific growth rate, the level of damage, the change in the frond area, copper concentration in plant tissues were determined. Results The action of γ-radiation (18, 42, 63 Gy) and copper ions (3, 5, 6.3 μmol/L) reduced the growth rate, increased the membrane lipid peroxidation, reduced the area of the fronds more significantly than under the separate action of the factors. The factors acted antagonistically on the specific growth rate. The content of copper in the tissues of irradiated plants (42, 63 Gy) increased. Conclusion Irradiation of duckweed with acute doses of gamma radiation reduced the resistance of plants to excess copper in the environment.
The Interplay Between the Immune System, the Renin‐Angiotensin‐Aldosterone System (RAAS), and RAAS Inhibitors May Modulate the Outcome of COVID‐19: A Systematic Review

Since the discovery of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), numerous research has been undertaken to delineate the various effects of the virus which manifests in many ways all over the body. The association between the SARS‐CoV‐2 invasion mechanism and the renin‐angiotensin‐aldosterone system (RAAS) receptors, created many debates about the possible consequences of using RAAS‐modulating drugs including angiotensin‐converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) during the pandemic. Many clinical studies were conducted to assess the outcomes of coronavirus disease 2019 (COVID‐19) in patients who use ACEi/ARBs following the arguments claiming to discontinue these drugs as a precautionary measure. Although several studies mainly analyzed the outcomes of the disease, this review aimed to compare specific blood markers in both groups of COVID‐19 patients to gain better insight into the interaction of ACEi/ARBs with different body functions during the infection. Several databases were searched using a combination of keywords followed by screening and data extraction. Only 28 studies met our inclusion criteria, the majority of which showed no significant difference between the inflammation markers of COVID‐19 patients who used or did not use ACEi/ARBs. Interestingly, 6 studies reported lower inflammatory markers in COVID‐19 patients who used ACEi/ARBs, and 6 studies reported better outcomes among the same group. We therefore concluded that the use of ACEi/ARBs may not lead to worse prognosis of COVID‐19 and may even play a protective role against the hyperinflammatory response associated with COVID‐19.