Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of mometasone furoate administered via a dry powder inhaler in the treatment of asthma

Abstract Background: Inhaled corticosteroids (ICSs) are effective controller medications that treat the chronic inflammation of asthma. The goal of asthma treatment is to improve lung function, symptoms, and the ability to perform daily activities, while decreasing the risk of exacerbations. Mometasone furoate delivered via a dry powder inhaler (MF-DPI) is indicated for once-daily maintenance treatment of asthma in patients as young as 4 years old. Objective: To review the quality of evidence for the clinical efficacy and safety of MF-DPI in both adults and children in the context of grading systems for guideline recommendations. Publications were identified by searching PubMed (MEDLINE) for ‘mometasone furoate AND dry powder inhaler AND asthma’ in any field with search limits for publications from 1 January 1995 to 1 August 2008. Findings: MF-DPI has been evaluated in 21 randomized, double-blind, active- or placebo-controlled trials in adults with asthma. Clinical trials investigating the efficacy in patients previously treated with only short-acting β2-agonists, other ICSs, or oral corticosteroids revealed that MF-DPI is efficacious in these populations. The results of a pooled analysis of ten trials and individual results of three long-term safety trials indicate that MF-DPI is well-tolerated with minimal adverse events. Six clinical trials of MF-DPI have been completed in children. Studies of pediatric patients treated with approved doses of MF-DPI indicate that children previously maintained on twice-daily treatment of other ICSs showed improvements in lung function, health-related quality of life, and rescue medication use. In addition, there is no effect on growth velocity or the hypothalamic–pituitary–adrenal axis. In both adults and children, once-daily dosing of MF-DPI has been demonstrated to be as efficacious as twice-daily dosing. Conclusion: The findings of this single-database review are that once-daily MF-DPI is efficacious and safe in both adults and children with asthma.
Effects of Hormone Therapy on Serum Lipid Levels in Postmenopausal Korean Women

Objectives This study was conducted to examine the effects of hormone therapy on serum lipid levels in postmenopausal Korean women. Methods This retrospective cohort study included 154 healthy postmenopausal Korean women. Seventy-nine women took oral estrogen (conjugated equine estrogen 0.625 mg/day or equivalent), and 75 applied estrogen transdermally using 0.1% 17β-estradiol gel. Micronized progesterone (MP) was added to 40 women of oral group and 49 women in transdermal group. Serum levels of triglyceride, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and lipoprotein (a) were measured before, 3 and 6 month after hormone therapy. Results At baseline, mean body mass index (BMI) were lower (22.76 vs. 23.74 kg/m2) and proportion of family history of cardiovascular disease (CVD) (61 vs. 39%) were higher in oral group. In oral group, LDL-C and lipoprotein(a) levels decreased, and triglyceride and HDL-C levels increased significantly after 3 and 6 months. There was no significant change in lipoprotein levels compared to the baseline in transdermal group. There were also no differences with additional MP. Changing pattern of HDL-C during 6 months was significantly different by the route of estrogen administration. Conclusion Oral estrogen therapy might be more beneficial than transdermal estrogen in terms of lipid in postmenopausal Korean women. The estrogen effects are not influenced by adding MP.
Effects of a Synthetic Analogue of Vasopressin on Vascular Smooth Muscle.∗

Summary PLV-2, a synthetic analogue of vasopressin, applied topically to the micro-vessels in the rat mesoappendix produces a graded dose response reduction in true capillary blood flow. The various vessel types contract from the venular to the arteriolar loops; the opposite of their normal profile of reactivity. This polypeptide, when injected i.v. in a single dose potentiates constrictor responses to topically applied catecholamines. In contrast to these microcirculatory effects, PLV-2 inhibits norepinephrine-induced contractions in the isolated rabbit aortic strip.
Measuring Patient-Perceived Hospital Service Quality: Validity and Managerial Usefulness of HCAHPS Scales

This study extends previous efforts to validate the Consumer Assessment of Healthcare Providers & Systems Hospital Survey (HCAHPS) instrument. Data from two non-profit hospitals are used to explore psychometric properties of the HCAHPS measures. The findings raise concerns that HCAHPS measures may not meet the standards for reliability and validity. The results are mixed in terms of the impact of HCAHPS dimensions on overall quality ratings of hospitals. Implications of the results are discussed and future research avenues are offered regarding the use and further refinement of the HCAHPS measures.
Implementation of a high efficiency and low cost converter for a photovoltaic water pumping system

This paper proposes a new converter for photovoltaic water pumping and treatment systems without the use of storage elements. The converter is designed to drive a three-phase induction motor directly from PV solar energy. The use of this motor has the objective of presenting a better solution to the standard DC motor water pumping system. The development is oriented to achieve a commercially viable solution and a market friendly product. The converter topology is based on a Resonant Two Inductor Boost converter and a Three-phase Voltage Source inverter achieving 90% efficiency at a rated power of 210W. The total cost of the proposed converter is below US$ 91.00 and the system is expected to have high lifetime, due to the inexistence of electrolytic capacitors.
Unsupervised and Supervised Learning Approaches Together for Microarray Analysis

In this article, a novel concept is introduced by using both unsupervised and supervised learning. For unsupervised learning, the problem of fuzzy clustering in microarray data as a multiobjective optimization is used, which simultaneously optimizes two internal fuzzy cluster validity indices to yield a set of Pareto-optimal clustering solutions. In this regards, a new multiobjective differential evolution based fuzzy clustering technique has been proposed. Subsequently, for supervised learning, a fuzzy majority voting scheme along with support vector machine is used to integrate the clustering information from all the solutions in the resultant Pareto-optimal set. The performances of the proposed clustering techniques have been demonstrated on five publicly available benchmark microarray data sets. A detail comparison has been carried out with multiobjective genetic algorithm based fuzzy clustering, multiobjective differential evolution based fuzzy clustering, single objective versions of differential evolution and genetic algorithm based fuzzy clustering as well as well known fuzzy c-means algorithm. While using support vector machine, comparative studies of the use of four different kernel functions are also reported. Statistical significance test has been done to establish the statistical superiority of the proposed multiobjective clustering approach. Finally, biological significance test has been carried out using a web based gene annotation tool to show that the proposed integrated technique is able to produce biologically relevant clusters of coexpressed genes.
Acanthamoeba profilin interacts with G-actin to increase the rate of exchange of actin-bound adenosine 5'-triphosphate.

A sevenfold molar excess of Acanthamoeba profilin, a 12 000-dalton protein that inhibits actin polymerization, increases the rate of exchange of ATP bound to G-actin with ATP in solution about 17-fold, i.e., from 7.7 x 10(-4) to 1.3 x 10(-2) S-1, at 25 degrees C, 0.033 mM Ca2+, and 0.1 mM ATP, pH 7.5. Detailed analysis of the equilibrium isotope-exchange data shows that profilin and actin form a 1:1 complex with KD = 4.7 x 10(-5) M and that the binding of profilin to actin is rapid and reversible. The actin-profilin complex binds 1 mol of ATP/mol, as does G-actin. Profilin does not interact with ATP or Ca2+.
UvA-DARE ( Digital Academic Repository ) A time-dependent jet model for the emission from Sagittarius A *

Context. The source of emission from Sgr A*, the supermassive black hole at the Galactic Center, is still unknown. Flares and data from multiwavelength campaigns provide important clues about the nature of Sgr A* itself. Aims. Here we attempt to constrain the physical origin of the broadband emission and the radio flares from Sgr A*. Methods. We developed a time-dependent jet model, which for the first time allows one to compare the model predictions with flare data from Sgr A*. Taking into account relevant cooling mechanisms, we calculate the frequency-dependent time lags and photosphere size expected in the jet model. The predicted lags and sizes are then compared with recent observations. Results. Both the observed time lags and size-frequency relationships are reproduced well by the model. The combined timing and structural information strongly constrain the speed of the outflow to be mildly relativistic, and the radio flares are likely to be caused by a transient increase in the matter channelled into the jets. The model also predicts light curves and structural information at other wavelengths which could be tested by observations in the near future. Conclusions. We show that a time-dependent relativistic jet model can successfully reproduce: (1) the quiescent broadband spectral energy distribution of Sgr A*; (2) the observed 22 and 43 GHz light curve morphologies and time lags; and (3) the frequency-size relationship. The results suggest that the observed emission at radio frequencies from Sgr A* is most easily explained by a stratified, optically thick, mildly relativistic jet outflow. Frequency-dependent measurements of time-lags and intrinsic source size provide strong constraints on the bulk motion of the jet plasma.
A Novel Interaction of Cap-binding Protein Complexes Eukaryotic Initiation Factor (eIF) 4F and eIF(iso)4F with a Region in the 3′-Untranslated Region of Satellite Tobacco Necrosis Virus*

Satellite tobacco necrosis virus (STNV) RNA is naturally uncapped at its 5′ end and lacks polyadenylation at its 3′ end. Despite lacking these two hallmarks of eukaryotic mRNAs, STNV-1 RNA is translated very efficiently. A ∼130-nucleotide translational enhancer (TED), located 3′ to the termination codon, is necessary for efficient cap-independent translation of STNV-1 RNA. The STNV-1 TED RNA fragment binds to the eukaryotic cap-binding complexes, initiation factor (eIF) 4F and eIF(iso)4F, as measured by nitrocellulose binding and fluorescence titration. STNV-1 TED is a potent inhibitor of in vitro translation when added in trans. This inhibition is reversed by the addition of eIF4F or eIF(iso)4F, and the subunits of eIF4F and eIF(iso)4F cross-link to STNV-1 TED, providing additional evidence that these factors interact directly with STNV-1 TED. Deletion mutagenesis of the STNV-1 TED indicates that a minimal region of ∼100 nucleotides is necessary to promote cap-independent translation primarily through interaction with the cap binding subunits (eIF4E or eIF(iso)4E) of eIF4F or eIF(iso)4F.
Gendered Triple Standard and Biomedical Management of Perinatal and Maternal Opioid Use Disorder in the United States

Despite trends towards treatment versus punitive-based approaches to addressing opioid use disorders (OUD) in the United States, pregnant and parenting women with OUD remain highly stigmatized, their maternal fitness routinely contested. Biomedical conceptions of OUD as a chronic, relapsing condition often run counter to the abstinence-based models enforced across the myriad institutions that manage OUD, particularly for women whose maternal status is contingent on treatment enrollment and adherence. Exposure to trauma is considered to be nearly universal among women with OUD; biomedical classifications of trauma primarily center on the interpersonal (i.e., adverse childhood [ACEs] and lifetime experiences). This work responds to a call to ‘gender addiction’ (Campbell and Ettorre 2011) and examine the ‘epistemologies of ignorance’ (Tuana 2006) around notions of ‘risk’ by advocating for a broadened definition of trauma that incorporates the institutional violence imbedded into policies and procedures specific to the biomedical management of OUD. Drawing from an 18-month ethnographic investigation of pregnant and parenting women with OUD living in the Northeastern United States. , this article argues that the intertwined institutions (e.g. medical, legal, and social services) that manage OUD according to biomedical dictates enact a converging constellation of violence on women; this in turn becomes a form of embodied trauma, directly influencing perinatal and maternal opioid use trajectories. Key findings include: (1) civil commitment to treatment as a form of direct bodily violence, (2) loss of maternal status as visceral violence, and (3) institutional erasures (i.e., intergenerational family separation) as symbolic violence.
Risk of Non‐Hodgkin's Lymphoma in Primary Sjögren's Syndrome: A Population‐Based Study

Primary Sjögren's syndrome (SS) is associated with an increased risk of non‐Hodgkin's lymphoma (NHL), but the reported prevalence and risk vary considerably. The objective of this study was to determine the risk of NHL in a well‐defined population‐based primary SS cohort in Norway.
Otorhinolaryngological Manifestation of Allergy in South Western Nigerian Children

Background: Allergy is a systemic, chronic and recurrent disorder of otorhinolaryngological importance. This disorder is often neglected with late presentation in paediatric age group. This study aimed at determining the prevalence, sociodemographic features, trigger factors, clinical features, complications, quality of life, associated comorbid illnesses and treatment outcome among children. Materials and Methods: This was a prospective hospital based study of children with allergy in our center. The study was carried out over a period of one year from May 2017 to April 2018. Data were obtained by using pretested self-administered questionnaire. Data obtained were documented, collated and analyzed by using SPSS version 18.0 Results: Prevalence of allergy in this study was 8.6%. There were 60.2% male with male to female ratio of 1.5:1. There was positive family history of allergy in 55.9% patients. Perennial allergy was the commonest in 68.3% of the children. Major forms of allergens were 71.5% inhalant and 9.7% ingestant. The common self-reported trigger factors were dust, cold weather and smoke in 58.1%, 41.9% and 22.0% respectively. Major associated comorbid illnesses in this study were 43.5% adenotonsillar hypertrophy. Commonest allergic symptoms were runny nose in 38.7%. The commonest affected organ was nose in 46.8%. Commonly affected quality of life was 22.6% irritability, 20.4% absenteeism, 19.9% sleep disruption and 12.9% impaired social life. Common complications were 48.9% secondary infection, 46.2% otitis media/externa, 44.1% injury, 42.5% foreign body impaction and 40.3% pharyngitis. Treatment of allergy leads to improvement and recovery from the clinical features in 52.2%. No significant improvement in 47.8%. Conclusion: Allergy is a systemic disease affecting ear, nose and throat. It affects all paediatric age group with associated comorbid illnesses, complications and affectation of quality of life at presentation in majority of the patients.
NEW ASPECTS OF FAMILY HISTORY OF HEART DISEASE AS A RISK FACTOR FOR CORONARY ARTERY DISEASE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Introduction-This an in-depth investigation of the relationship between some new aspects of positive family history (FH) of coronary artery disease (CAD) and other risk factors related to CAD in patients with acute myocardial infarction (AMI). Method- The data of 200 patients with AMI and positive FH of CAD (FH Pos.)- as case group- and 200 AMI patients without FH of CAD -as control group- (FH Neg.) were collected. Information about first and second-degree relatives was obtained, including age, occurrence of MI, and other risk factors related to CAD. We also covered procedures such as coronary angiography (CAG), percutaneous intervention (PCI), and coronary artery bypass grafting (CABG) surgery. Results- AMI with ST-segment elevation in ECG (69.61% vs. 26.76%), heart block (19.47%. vs. 6.34%), and low EF (mean 43±3.4% vs. 47±35%) were higher in the FH Pos. group than the FH Neg. group. As well as diabetes (42.71% vs. 11.27%), dyslipidemia (42.19% vs. 14%), and hypertension (73.74% vs. 64.79%) in the FH Pos. group were higher than those in the FH Neg. group. CAG (79.9% vs. 39.9%) and CABG (34.8% vs14.79%) were higher in the FH Pos. group (all p values<0.05). More patients in the FH Pos. group were male and younger. In the FH Pos. group, there was 65% positive finding in the second-degree relatives; most of these second-degree relatives came from the father’s side (56%). Also, there were 1.35 times more events in brothers than in sisters. Conclusion- Subjects with a positive family history of CAD were younger and more susceptible to CAD and needed frequent interventional procedures. Also, there was a difference in the power of various kinds of positive FH. In the FH Pos. arm, there was a stronger relationship between the patient and his/her brothers than with sisters and 56% incidence in the second-degree relatives (especially from the father’s side) (Iranian Heart Journal 2011; 12 (3):6-11).
Comparative study between optimized controllers fuzzy X MPC

This paper presents comparative study between Fuzzy and Predictive controllers. They are implemented to speed control of a direct current (DC) machine, triggered by fully controlled three-phase AC-DC converter. Searching for high performance controllers, it's performed controllers' parameters optimization, through the use of the heuristic method Genetic Algorithm. It seeks to determine which of the controllers will present better performance, given the same operation's conditions.
Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells.

PC cell-derived growth factor (PCDGF) is an 88 kDa glycosylated protein isolated from a highly tumorigenic mouse teratoma derived cell line which is similar to the epithelin/granulin precursor. Using Northern blot and western blot analyses, we detect the expression of PCDGF mRNA and protein in MCF-7 human breast cancer cells. We show that 17-beta-estradiol stimulates PCDGF mRNA and protein expression in a time and dose-dependent manner. The stimulation of PCDGF expression by 17-beta-estradiol was observed as early as 4 hours and reached a maximum at 12 hours. Maximal stimulation of PCDGF mRNA and protein expression by 17-beta-estradiol was observed at a concentration of 10(-8) M. The stimulation of PCDGF expression by 17-beta-estradiol was completely inhibited by treatment with actinomycin D and with the antiestrogen 4-hydroxytamoxifen. The stimulation of PCDGF expression was also demonstrated in another human estrogen-responsive cell line T47D. The results presented here provide evidence of a novel estradiol responsive gene product in human breast cancer cell lines and give information about the hormonal control of epithelin/granulin (PCDGF) expression in these cells.
Laser patterning of platinum electrodes for safe neurostimulation

Objective. Laser surface modification of platinum (Pt) electrodes was investigated for use in neuroprosthetics. Surface modification was applied to increase the surface area of the electrode and improve its ability to transfer charge within safe electrochemical stimulation limits. Approach. Electrode arrays were laser micromachined to produce Pt electrodes with smooth surfaces, which were then modified with four laser patterning techniques to produce surface structures which were nanosecond patterned, square profile, triangular profile and roughened on the micron scale through structured laser interference patterning (SLIP). Improvements in charge transfer were shown through electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and biphasic stimulation at clinically relevant levels. A new method was investigated and validated which enabled the assessment of in vivo electrochemically safe charge injection limits. Main results. All of the modified surfaces provided electrical advantage over the smooth Pt. The SLIP surface provided the greatest benefit both in vitro and in vivo, and this surface was the only type which had injection limits above the threshold for neural stimulation, at a level shown to produce a response in the feline visual cortex when using an electrode array implanted in the suprachoroidal space of the eye. This surface was found to be stable when stimulated with more than 150 million clinically relevant pulses in physiological saline. Significance. Critical to the assessment of implant devices is accurate determination of safe usage limits in an in vivo environment. Laser patterning, in particular SLIP, is a superior technique for improving the performance of implant electrodes without altering the interfacial electrode chemistry through coating. Future work will require chronic in vivo assessment of these electrode patterns.
Instrumental Representations of Sensorimotor Control: Representations at Immediate Level

In cognitive science, computation is largely accompanied with representational theory of mind. Yet, it remains unclear whether this companionship also appears in the realm of sensorimotor control. Grush’s (2004) and Pezzulo’s (2008, 2011) account of anticipatory representations provide a limited answer, as they are only suitable for forward models, but not the entire sensorimotor control. Rescorla’s (2016) representational explanation for sensorimotor psychology addresses several intentional states considered in Bayesian inference and optimal modeling. However, the above accounts does not explain how motor commands are produced and chosen in the course of sensorimotor control for maintaining accuracy of goal-achievement. The present paper aims to explain it with a representational account by considering instrumental representations of sensorimotor control, which appear at the intermediate level and are exemplified by motor commands and costs. Such representations do not presume decouplability, as they need to run on-line in the maintenance of accuracy.
Genetic and biochemical definition of the Hedgehog receptor Material Supplemental

Material Supplemental http://genesdev.cshlp. org/content/suppl/2009/12/14/24.1. 57.DC1. html References http://genesdev.cshlp. org/content/24/1/57.full. html#ref-list-1 This article cites 70 articles, 20 of which can be accessed free at: Open Access Freely available online through the Genes & Development Open Access option. service Email alerting click here top right corner of the article or Receive free email alerts when new articles cite this article sign up in the box at the
Índices precoces de patología endocrinometabólica y cardiovascular en los recién nacidos con crecimiento intrauterino retrasado

En los CIR no se conocen bien las adaptaciones a la desnutricion que dan lugar a obesidad, resistencia insulinica, diabetes y mayor riesgo cardiovascular en la edad adulta. La explicacion mas factible de esta asociacion es la hipotesis del crecimiento recuperador. Durante la vida intrauterina, el metabolismo fetal esta continuamente reajustandose al crecimiento lento. Cuando esta adaptacion es incongruente con la nutricion postnatal, puede asociarse con una ganancia ponderal rapida durante la infancia. Esto puede dar lugar a una adaptacion que predispone a un conjunto de signos relacionados con el sindrome metabolico, aumentando el riesgo de comorbilidades (obesidad, diabetes, dislipemia, enfermedad coronaria e hipertension). Algunos estudios postulan una mayor influencia del crecimiento recuperador frente al propio bajo peso al nacimiento en el desarrollo de posterior patologia cardiovascular y endocrinometabolica.