Miracle-dz/UniFAR-FTUs huggingface dataset:
Manual therapy for unsettled, distressed and excessively crying infants: a systematic review and meta-analyses

Objective To conduct a systematic review and meta-analyses to assess the effect of manual therapy interventions for healthy but unsettled, distressed and excessively crying infants and to provide information to help clinicians and parents inform decisions about care. Methods We reviewed published peer-reviewed primary research articles in the last 26 years from nine databases (Medline Ovid, Embase, Web of Science, Physiotherapy Evidence Database, Osteopathic Medicine Digital Repository , Cochrane (all databases), Index of Chiropractic Literature, Open Access Theses and Dissertations and Cumulative Index to Nursing and Allied Health Literature). Our inclusion criteria were: manual therapy (by regulated or registered professionals) of unsettled, distressed and excessively crying infants who were otherwise healthy and treated in a primary care setting. Outcomes of interest were: crying, feeding, sleep, parent–child relations, parent experience/satisfaction and parent-reported global change. Results Nineteen studies were selected for full review: seven randomised controlled trials, seven case series, three cohort studies, one service evaluation study and one qualitative study. We found moderate strength evidence for the effectiveness of manual therapy on: reduction in crying time (favourable: −1.27 hours per day (95% CI −2.19 to –0.36)), sleep (inconclusive), parent–child relations (inconclusive) and global improvement (no effect). The risk of reported adverse events was low: seven non-serious events per 1000 infants exposed to manual therapy (n=1308) and 110 per 1000 in those not exposed. Conclusions Some small benefits were found, but whether these are meaningful to parents remains unclear as does the mechanisms of action. Manual therapy appears relatively safe. PROSPERO registration number CRD42016037353.
Performance improvement model of regression test selection

The size of test case reduction using test cases of the improved program is considered as a primary purpose of developing various regression test selections. This also concerns with fault avoidance that could be found from some test cases selections. This study focuses and compares the proficiency of solving these two problems using the three methods from previous studies; original regression test, code coverage based, and filtering-based selections; and a new proposed model. This model carries on five processes; 1) testing test suit and looking for passed or failed test cases, 2) correcting failures that can be restored, 3) categorizing all passed test cases into four areas: user, system, functional, and non-functional cases, 4) taking out irrelevant objects, 5) selecting the proper test case. The study found that the result of the size reduction using the proposed model is much larger than the existing methods by 2.49%-8.55%, while the percentage of avoiding faults using the existing algorithms are lower than the new proposed algorithm around 0.58%-2.36%.
Spontaneous body sway as a function of sex, age, and vision: posturographic study in 30 healthy adults.

Detailed neurological examinations and body sway measurements with a stable force measuring platform were carried out on 30 healthy adults between 21 and 63 years of age. The results were analyzed for sex- and age-associated changes with regard to three different sway components (total sway, anterio-posterior sway, lateral sway) and two different conditions (eyes open, eyes closed). Sex-associated differences were highly significant for all sway components in the oldest age group (51-65 years) in which men exhibited more spontaneous postural sway than women in the condition eyes open. With eyes closed these differences increased. Middle-aged men (36-50 years) also exhibited significantly more postural sway than women of the same age. In the condition eyes open especially total sway and anterioposterior sway were increased, whereas in the condition eyes closed total sway and lateral sway were predominantly higher in men than in women. In the youngest age group (21-35 years) no sex-related differences in postural sway were found. Age-associated differences were significant for anterioposterior sway (eyes open) in men, increasing continuously from the young to the middle-aged, and again from the middle-aged to the older age group. Anterioposterior sway in women, on the contrary, did not change with age. Age-associated differences in women were found for total sway (eyes open) and lateral sway (eyes closed). However, the highest values for total sway and lateral sway within the female group were obtained from young women in both conditions eyes open and eyes closed. (ABSTRACT TRUNCATED AT 250 WORDS)
Desensitization of the hypothalamic-pituitary-adrenal axis following prolonged administration of corticotropin-releasing hormone or vasopressin.

The responses of the hypothalamic-pituitary-adrenal axis during chronic stress are characterized by normal or slightly elevated plasma ACTH, increased hypothalamic corticotropin-releasing hormone (CRH) and vasopressin secretion, decreased pituitary CRH receptors and hypersensitivity of the ACTH and glucocorticoid responses to a novel stress. To determine the role of CRH and vasopressin in the pituitary hyperresponsiveness to a superimposed stress, pituitary CRH receptors and plasma ACTH responses were measured in rats receiving minipump infusions of CRH or a combination of CRH and vasopressin (VP), 50 ng/min of each for 50 h. Rats were killed by decapitation with or without exposure to ether vapor for 5 min or immobilization for 15 or 30 min, and blood was collected for ACTH and corticosterone determinations. The pituitary CRH receptor concentration measured by binding 125I-Tyr-oCRH, was reduced by 45 and 80% in CRH- and CRH-plus-VP-infused rats, respectively, with no changes in receptor affinity. Acute stress by ether exposure or immobilization had no effect on pituitary CRH receptors. Adrenal weight was significantly increased, and thymus weight decreased in CRH-infused animals, indicating activation of the pituitary adrenal axis. However, in contrast to the responses following chronic stress, the increases in plasma ACTH in response to an injection of 10 micrograms/kg CRH or acute stress were significantly lower in CRH- and CRH-plus-VP-infused rats. Furthermore the content and release of ACTH from quartered pituitaries were also decreased in chronically treated rats. (ABSTRACT TRUNCATED AT 250 WORDS)
Targeting astrocytes in major depression

Astrocytes represent a highly heterogeneous population of neural cells primarily responsible for the homeostasis of the CNS. Astrocytes express multiple receptors for neurotransmitters, including the serotonin 5-HT2B receptors and interact with neurones at the synapse. Astroglia contribute to neurological diseases through homeostatic response, neuroprotection and reactivity. In major depression, astrocytes show signs of degeneration and are decreased in numbers, which may lead to a misbalance in neurotransmission and aberrant synaptic connectivity. In this review, we summarize astroglia-specific effects of major antidepressants and outline future strategies for astroglia-specific therapy in neuropsychiatric disorders.
Internet of things for neophytes: A survey

Advancement in the Internet makes things and objects to work efficient and smarter, which has constituted to form the term called Internet of Things (IoT). According to the predictions made by technical giants, researcher's and survey organization, concludes that there could be around 50 billion devices connected to Internet opens up for new innovations, research publications and development in the area of IoT. So in order to facilitate this movement this survey provides basic information on IoT to the starters. This survey mainly includes IoT architecture, protocols and operating system, finally the review is concluded with potential IoT issues and challenges.
A Novel Hybrid Similarity Calculation Model

This paper addresses the problems of similarity calculation in the traditional recommendation algorithms of nearest neighbor collaborative filtering, especially the failure in describing dynamic user preference. Proceeding from the perspective of solving the problem of user interest drift, a new hybrid similarity calculation model is proposed in this paper. This model consists of two parts, on the one hand the model uses the function fitting to describe users’ rating behaviors and their rating preferences, and on the other hand it employs the Random Forest algorithm to take user attribute features into account. Furthermore, the paper combines the two parts to build a new hybrid similarity calculation model for user recommendation. Experimental results show that, for data sets of different size, the model’s prediction precision is higher than the traditional recommendation algorithms.
An investigation on the use of convolutional neural network for image classification in embedded systems

The study of Convolutional Neural Network (CNN) for image classification is basically carried out on high performance and parallel platforms, so that the results of the literature cannot be replied on embedded systems. The aim of our work is to investigate CNN architectures that can run in such limited platforms and still maintain or improve the results of the current approaches. To that end, we specify and evaluate the performance of several CNN frameworks using different network configurations and dataset pre-processing techniques. The results of our final approach show that its classification efficiency is close to the best results of the literature, however using a much lower computational power.
Neutrophils in cystic fibrosis

Abstract Cystic fibrosis (CF) lung disease is characterized by chronic infection and inflammation. Among inflammatory cells, neutrophils represent the major cell population accumulating in the airways of CF patients. While neutrophils provide the first defensive cellular shield against bacterial and fungal pathogens, in chronic disease conditions such as CF these short-lived immune cells release their toxic granule contents that cause tissue remodeling and irreversible structural damage to the host. A variety of human and murine studies have analyzed neutrophils and their products in the context of CF, yet their precise functional role and therapeutic potential remain controversial and incompletely understood. Here, we summarize the current evidence in this field to shed light on the complex and multi-faceted role of neutrophils in CF lung disease.
Neurologic Sequelae after Severe Falciparum Malaria in Adult Travelers

Severe falciparum malaria usually occurs in nonimmune patients, namely children in endemic areas or travelers returning from tropical areas. It generally has one of two outcomes: rapid death or cure without sequelae. Neurologic sequelae have been reported in children but have not been described in detail in adults. The purpose of this study was to determine the clinical spectrum, neuroimaging aspects and long-term outcome of these sequelae. We describe six imported cases of severe malaria with neurologic sequelae in adults, seen in a Parisian university hospital over a 10-year period. The most striking findings were neuropsychological disorders, in particular memory impairment and diffuse white matter damage on magnetic resonance imaging. Only three of the patients had made a full recovery after 6 months.
Diffusion measurements of CO, HNCO, H2CO, and NH3 in amorphous water ice

Context. Water is the major component of the interstellar ice mantle. In interstellar ice, chemical reactivity is limited by the diffusion of the reacting molecules, which are usually present at abundances of a few percent with respect to water. Aims. We want to study the thermal diffusion of H2CO, NH3, HNCO, and CO in amorphous water ice experimentally to account for the mobility of these molecules in the interstellar grain ice mantle. Methods. In laboratory experiments performed at fixed temperatures, the diffusion of molecules in ice analogues was monitored by Fourier transform infrared spectroscopy. Diffusion coefficients were extracted from isothermal experiments using Fick's second law of diffusion. Results. We measured the surface diffusion coefficients and their dependence with the temperature in porous amorphous ice for HNCO, H2CO, NH3, and CO. They range from 10(-15) to 10(-11) cm(2) s(-1) for HNCO, H2CO, and NH3 between 110 K and 140 K, and between 5-8 x 10(-13) cm(2) s(-1) for CO between 35 K and 40 K. The bulk diffusion coefficients in compact amorphous ice are too low to be measured by our technique and a 10(-15) cm(2) s(-1) upper limit can be estimated. The amorphous ice framework reorganization at low temperature is also put in evidence. Conclusions. Surface diffusion of molecular species in amorphous ice can be experimentally measured, while their bulk diffusion may be slower than the ice mantle desorption kinetics.
Which is the most recommended medium for the storage and transport of avulsed teeth? A systematic review

BACKGROUND/AIMS A wide variety of materials has been researched for their use as potential storage media for avulsed teeth, but it is essential to recognize the medium most recommended for improvement of the prognosis of avulsed teeth. The aim of this systematic review was to identify the most recommended medium to store and transport avulsed teeth based on the survival of periodontal ligament (PDL) cells as determined by in vitro studies. METHODS Only laboratory-based experimental studies on PDL cells found on adult permanent teeth were included. Data were collected using PubMed, CINAHL plus (EBSCO host), and the Cochrane Library, along with Google Scholar and a hand search. The key terms employed were permutations of [avulsed permanent teeth* OR dental avulsion* OR knocked out teeth*] AND [storage media* OR transport media* OR biological transport* OR PDL cell viability* OR PDL cell survival*]. A customized data extraction pro forma was used to extract the data and to evaluate the quality and risk of bias. RESULTS The initial search yielded 978 articles, but only 67 were selected. Milk was the most recommended individual medium followed by Hank's balanced salt solution. Among natural products other than milk, propolis and coconut water were most frequently recommended. Recommendations were based on maintenance of PDL cell viability followed by ease of availability, low cost, and long shelf life. CONCLUSIONS Natural products are more effective in maintaining the PDL cell viability compared to synthetic products. Some storage media recommendations were also based upon practical aspects. Although natural products other than milk have more recommendations as a group, milk is the most recommended storage medium individually, based not only on PDL cell viability, but also practical considerations.
Image segmentation improvement by reversible segment merging

The paper focuses on image segmentation by means of approaching by piecewise-constant approximations. The objective is the improvement of the segmented image, expressed in the noticeable drop of image approximation error (total squared error). The proposed method involves segment dividing into two in some image part and merge of a pair of adjacent segments in another image part, keeping a total segment number constant. For further enhancement of the segmentation, the proposed method is used in combination with advanced K-means method. The steep decline of the approximation error is provided along with obvious increase of perceptual quality of image segmentation. The effect is achieved owing to binary adaptive hierarchy of nested segments, generated for each segment. The segmentation improvement method is usable for the advancement of the computer vision systems using conventional segmentation by partitioning image into connected segments.
Fault detection and isolation for wind turbine electric pitch system

This paper presents a model-based fault detection and isolation scheme applied on electric pitch system of wind turbines. Pitch system is one of the most critical components due to its effect on the operational safety and the dynamics of wind turbines. Faults in this system should be precisely detected to prevent failures and decrease downtime. To detect faults of electric pitch actuators and sensors, an extended kalman filter (EKF) based multiple model adaptive estimation (MMAE) designed to estimate the states of the system. The proposed method is demonstrated in case studies. The simulation results show that the proposed method detects different fault scenarios of wind turbines under the stochastic external condition.
Genome‐Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor

Rationale: Genetic factors are involved in acute respiratory distress syndrome (ARDS) susceptibility. Identification of novel candidate genes associated with increased risk and severity will improve our understanding of ARDS pathophysiology and enhance efforts to develop novel preventive and therapeutic approaches. Objectives: To identify genetic susceptibility targets for ARDS. Methods: A genome‐wide association study was performed on 232 African American patients with ARDS and 162 at‐risk control subjects. The Identify Candidate Causal SNPs and Pathways platform was used to infer the association of known gene sets with the top prioritized intragenic SNPs. Preclinical validation of SELPLG (selectin P ligand gene) was performed using mouse models of LPS‐ and ventilator‐induced lung injury. Exonic variation within SELPLG distinguishing patients with ARDS from sepsis control subjects was confirmed in an independent cohort. Measurements and Main Results: Pathway prioritization analysis identified a nonsynonymous coding SNP (rs2228315) within SELPLG, encoding P‐selectin glycoprotein ligand 1, to be associated with increased susceptibility. In an independent cohort, two exonic SELPLG SNPs were significantly associated with ARDS susceptibility. Additional support for SELPLG as an ARDS candidate gene was derived from preclinical ARDS models where SELPLG gene expression in lung tissues was significantly increased in both ventilator‐induced (twofold increase) and LPS‐induced (5.7‐fold increase) murine lung injury models compared with controls. Furthermore, Selplg−/− mice exhibited significantly reduced LPS‐induced inflammatory lung injury compared with wild‐type C57/B6 mice. Finally, an antibody that neutralizes P‐selectin glycoprotein ligand 1 significantly attenuated LPS‐induced lung inflammation. Conclusions: These findings identify SELPLG as a novel ARDS susceptibility gene among individuals of European and African descent.
Hybridization of RSA and AES algorithms for authentication and confidentiality of medical images

Image security is an essential part of communication through network. Nowadays the use of network and transmission of images has been widely increased. These images can be attacked by intruders and destroy the quality of the images or modified the images for illegal use. Considering these issues the proposed system ensuring the confidentiality, integrity and authentication of images using symmetric and asymmetric key cryptographic algorithm. Which make use of hybridization of two techniques i.e., RSA and AES for authentication and confidentiality. For improving the image integrity proposed system implemented image watermarking using LSB hiding algorithm. Watermarking is the process of hiding one image into another for copyright protection. RSA will be used for key generation and once key get generated, using AES algorithm watermarked image will be encrypted and send through a network. The receiving end the image will be decrypted and retrieved original watermark image.
Maternal High Fructose Intake Increases the Vulnerability to Post-Weaning High-Fat Diet-Induced Programmed Hypertension in Male Offspring

Widespread consumption of high-fructose and high-fat diets relates to the global epidemic of hypertension. Hypertension may originate from early life by a combination of prenatal and postnatal nutritional insults. We examined whether maternal high-fructose diet increases vulnerability to post-weaning high-fructose or high-fat diets induced hypertension in adult offspring and determined the underlying mechanisms. Pregnant Sprague-Dawley rats received regular chow (ND) or chow supplemented with 60% fructose (HFR) during the entire pregnancy and lactation periods. Male offspring were onto either the regular chow, 60% fructose, or high-fat diet (HFA) from weaning to 12 weeks of age and assigned to four groups: ND/ND, HFR/ND, HFR/HFR, and HFR/HFA. Maternal high-fructose diet exacerbates post-weaning high-fat diet-induced programmed hypertension. Post-weaning high-fructose and high-fat diets similarly reduced Sirt4, Prkaa2, Prkag2, Ppara, Pparb, and Ppargc1a mRNA expression in offspring kidneys exposed to maternal high-fructose intake. Additionally, post-weaning high-fat diet significantly reduced renal mRNA levels of Ulk1, Atg5, and Nrf2 and induced greater oxidative stress than did high-fructose diet. Although maternal high-fructose intake increases soluble epoxide hydrolase (SEH) expression in the kidney, which was restored by post-weaning high-fructose and high-fat diets. Maternal high-fructose diet programs differential vulnerability to developing hypertension in male offspring in response to post-weaning high-fructose and high-fat diets. Our data implicated that specific therapy targeting on nutrient sensing signals, oxidative stress, and SEH may be a promising approach to prevent hypertension in children and mothers exposed to high-fructose and high-fat consumption.
Validating genome-wide associated signals for clinical mastitis in German Holstein cattle.

A validation study for six genomic regions previously identified by a genome-wide association study for somatic cell score was conducted with data of clinical mastitis in German Holstein cattle. Out of 10 tested SNPs, five on chromosomes 6, 13 and 19 were significantly associated with clinical mastitis (P < 0.05). Three SNPs on chromosomes 6 and 19 had the same direction of effect as those previously reported in the initial genome-wide association study for somatic cell score. The other two SNPs on chromosome 13 had opposite effects. As well as validating associations within known QTL from previous studies, e.g. chromosomes 6 and 19, novel loci on chromosome 13 were confirmed. Promising candidate genes are, for example: deoxycytidine kinase, immunoglobulin J chain, vitamin D binding protein, forkhead box K2, sodium/hydrogen exchanger 8 and cytoplasmic nuclear factor of activated T-cells 2. Our confirmation study provides additional evidence for the functional role of the linked genomic regions to immune response. This information can be used as a basis for further functional studies for those potential genes.
Use of bacterial whole-genome sequencing to understand and improve the management of invasive Staphylococcus aureus infections

ABSTRACT Introduction: Management of invasive Staphylococcus aureus infections is complex. Dramatic improvements in bacterial whole genome sequencing (WGS) offer new opportunities for personalising the treatment of S. aureus infections. Areas covered: We address recent achievements in S. aureus genomics, describe genetic determinants of antibiotic resistance and summarise studies that have defined molecular characteristics associated with risk and outcome of S. aureus invasive infections. Potential clinical use of WGS for resistance prediction, infection outcome stratification and management of persistent /relapsing infections is critically discussed. Expert commentary: WGS is not only providing invaluable information to track the emergence and spread of important S. aureus clones, but also allows rapid determination of resistance genotypes in the clinical environment. An evolving opportunity is to infer clinically important outcomes and optimal therapeutic approaches from widely available S. aureus genome data, with the goal of individualizing management of invasive S. aureus infections.