Miracle-dz/UniFAR-FTUs huggingface dataset:
Perception of Musical Emotion in the Students with Cognitive and Acquired Hearing Loss

Objective Hearing loss can affect the perception of emotional reaction to the music. The present study investigated whether the students with congenital hearing loss exposed to the deaf culture, percept the same emotion from the music as students with acquired hearing loss. Materials & Methods Participants were divided into two groups; 30 students with bilaterally congenital moderate to severe hearing loss that were selected from deaf schools located in Tehran, Iran and 30 students with an acquired hearing loss with the same degree of hearing loss selected from Amiralam Hospital, Tehran, Iran and compared with the group of 30 age and gender-matched normal hearing subjects served our control in 2012. The musical stimuli consisted of three different sequences of music, (sadness, happiness, and fear) each with the duration of 60 sec. The students were asked to point to the lists of words that best matched with their emotions. Results Emotional perception of sadness, happiness, and fear in congenital hearing loss children was significantly poorly than acquired hearing loss and normal hearing group (P<0.001). There was no significant difference in the emotional perception of sadness, happiness, and fear among the group of acquired hearing loss and normal hearing group (P=0.75), (P=1) and (P=0.16) respectively. Conclusion Neural plasticity induced by hearing assistant devises may be affected by the time when a hearing aid was first fitted and how the auditory system responds to the reintroduction of certain sounds via amplification. Therefore, children who experienced auditory input of different sound patterns in their early childhood will show more perceptual flexibility in different situations than the children with congenital hearing loss and Deaf culture
MANAGING ORGANIZATIONAL LEGITIMACY OF PUBLIC PRIVATE JOINT VENTURES - A CASE STUDY

This paper examines the general manageability of issues affecting the overall organisational legitimacy of public private joint ventures (PPJVs) by investigating Namdeb, a PPJV between De Beers and the Government of Namibia. 42 interviews were conducted – 41 with stakeholders and one with the focal organisation, Namdeb. Results show that the company’s organisational legitimacy is affected by a number of political, economic, social, environmental and legislative factors which are often interrelated and complex. It is concluded that on the one hand, most of the issues are controllable and that companies are able, to a great extent, influence their organisational legitimacy. On the other hand, managing organisational legitimacy is a complex process as companies do not always have control over issues affecting their legitimacy. The data also shows that most issues affecting organisational legitimacy are moral and to a lesser extent pragmatic and cognitive. In order to garner organisational legitimacy, managers are advised to address issues individually and not to invest only in an overall communication strategy as stakeholders expect appropriate and effective action, for example in cases where the rights of stakeholders are violated and where issues of corruption are evident.
Role of moral values in the trade-off between animal welfare and food safety risks in broiler husbandry

To cope with societal concerns regarding animals kept in intensive systems, alternative broiler husbandry systems that comply with above-legal animal welfare standards, such as the free-range barn system have been introduced. However, broilers in free-range barn systems show higher Campylobacter contaminations than broilers in conventional systems, which might entail a higher risk of Campylobacter infections in consumers. This causes a dilemma between animal welfare and food safety. To make a trade-off, moral values concerning humans and broilers must be weighed. Moral values are deeply rooted and shared in society, but in a specific case they depend on the context and are weighed against each other. To get insight into the role of moral values in the dilemma between broiler welfare and food safety, citizens (n=2,259) and poultry farmers (n=100) were surveyed. First, participants were questioned about 13 moral values regarding chickens and consumers. Next, they were presented a case concerning a broiler farmer who would like to change from a conventional husbandry system to a free-range barn system that complies above-legal welfare standards, but which entails higher Campylobacter contamination of broilers. Respondents were asked whether they agreed with the change from the conventional husbandry systems to the free-range barn system. Additionally, respondents scored the importance of arguments based on moral values and relevance for the case. Citizens and farmers scored equally only the statements regarding chickens being sentient and human health. Both citizens and farmers who agreed with the change of the husbandry system considered the arguments concerning broiler welfare more important than respondents who did not agree with the change of system. This study provides input for deliberation on broiler husbandry especially on the dilemma between broiler welfare and food safety. With the information form this study a broad moral deliberation could be set up between the different stakeholders to define characteristics of future husbandry systems that can count on support from both the poultry sector and citizens.
Studies of the Thymelaeaceae II. Antineoplastic principles of Gnidia kraussiana.

The acetone and methanol extracts of Gnidia kraussiana roots displayed activity against the P-388 lymphocytic leukemia. Bioactivity-directed fractionation led to the isolation of five daphnane orthoesters , all possessing potent antineoplastic activity. Four of these isolates, gnidilatin (1), gnidilatidin (2), Excoecaria toxin (3), and Pimelea factor P2 (4) have been isolated previously from plants in the Thymelaeaceae and Euphorbiaceae. The fifth compound, kraussianin (5), is a new member of the macrocyclic daphnane orthoester series of compounds.
The epileptic amygdala: Toward the development of a neural prosthesis by temporally coded electrical stimulation

Many patients with epilepsy do not obtain proper control of their seizures through conventional treatment. We review aspects of the pathophysiology underlying epileptic phenomena, with a special interest in the role of the amygdala, stressing the importance of hypersynchronism in both ictogenesis and epileptogenesis. We then review experimental studies on electrical stimulation of mesiotemporal epileptogenic areas, the amygdala included, as a means to treat medically refractory epilepsy. Regular high‐frequency stimulation (HFS) commonly has anticonvulsant effects and sparse antiepileptogenic properties. On the other hand, HFS is related to acute and long‐term increases in excitability related to direct neuronal activation, long‐term potentiation, and kindling, raising concerns regarding its safety and jeopardizing in‐depth understanding of its mechanisms. In turn, the safer regular low‐frequency stimulation (LFS) has a robust antiepileptogenic effect, but its pro‐ or anticonvulsant effect seems to vary at random among studies. As an alternative, studies by our group on the development and investigation of temporally unstructured electrical stimulation applied to the amygdala have shown that nonperiodic stimulation (NPS), which is a nonstandard form of LFS, is capable of suppressing both acute and chronic spontaneous seizures. We hypothesize two noncompetitive mechanisms for the therapeutic role of amygdala in NPS, 1) a direct desynchronization of epileptic circuitry in the forebrain and brainstem and 2) an indirect desynchronization/inhibition through nucleus accumbens activation. We conclude by reintroducing the idea that hypersynchronism, rather than hyperexcitability, may be the key for epileptic phenomena and epilepsy treatment. © 2016 Wiley Periodicals, Inc.
INTERSECTING TAX CONCENTRATION CURVES AND THE MEASUREMENT OF TAX PROGRESSIVITY: A COMMENT

of Tax Progressivity," Formby, Smith and Sykes (FSS) misinterpret the meaning of the index measure of tax progressivity developed by Suits (1977) and used by Clotfelter (1979) in his analysis of gambling taxes. Only the Suits definition and measurement of tax progressivity will be reviewed here. As Musgrave and Thin (MT) (1948) pointed out some years ago, there are a number of ways in which the degree of tax progressivity can be defined. Quite different results can be obtained depending on which definition and measurement is used.
Carriage Frequency, Intensity of Carriage, and Strains of Oral Yeast Species Vary in the Progression to Oral Candidiasis in Human Immunodeficiency Virus-Positive Individuals

ABSTRACT Candida samples were taken over a period of 2 years from 54 human immunodeficiency virus (HIV)-positive asymptomatic subjects to evaluate changes in yeast carriage, intensity of carriage, and genotype over time. Overall, we found that HIV-positive patients with CD4+-cell counts of between 200 and 400/μl had significantly more yeast colonization than healthy control subjects. Of the 54 patients, 11 developed thrush. We found that intensity of carriage in these 11 patients increased significantly in the progression from asymptomatic yeast carrier to an episode of oral thrush. Also, the most common yeast species isolated was Candidaalbicans; however, we did see a number of patients harboring multiple species at the same time. Using the C. albicans-specific probe Ca3, we found that 54% (n = 6) of the 11 patients who developed thrush maintained genetically similar strains throughout the study period, with minor genetic variations in all patients except one. Forty-six percent of these patients had either multiple strains throughout the study period (n = 2), strain replacement (n = 1), or species replacement (n = 2). Of the patients who had multiple strains, one (I4) was infected by two different strains of Candidadubliniensis distinguished by a recently developed species-specific probe. These results suggest that commensal strains colonizing HIV-positive individuals can undergo alterations prior to producing an episode of thrush.
Algorithmic psychometrics and the scalable subject

Recent public controversies, ranging from the 2014 Facebook ‘emotional contagion’ study to psychographic data profiling by Cambridge Analytica in the 2016 American presidential election, Brexit referendum and elsewhere, signal watershed moments in which the intersecting trajectories of psychology and computer science have become matters of public concern. The entangled history of these two fields grounds the application of applied psychological techniques to digital technologies, and an investment in applying calculability to human subjectivity. Today, a quantifiable psychological subject position has been translated, via ‘big data’ sets and algorithmic analysis, into a model subject amenable to classification through digital media platforms. I term this position the ‘scalable subject’, arguing it has been shaped and made legible by algorithmic psychometrics – a broad set of affordances in digital platforms shaped by psychology and the behavioral sciences. In describing the contours of this ‘scalable subject’, this paper highlights the urgent need for renewed attention from STS scholars on the psy sciences, and on a computational politics attentive to psychology, emotional expression, and sociality via digital media.
FUN-LDA: A LATENT DIRICHLET ALLOCATION MODEL FOR PREDICTING TISSUE-SPECIFIC FUNCTIONAL EFFECTS OF NONCODING VARIATION

We describe here a new method based on a latent Dirichlet allocation model for predicting functional effects of noncoding genetic variants in a cell type and tissue specific way (FUN-LDA) by integrating diverse epigenetic annotations for specific cell types and tissues from large scale epige-nomics projects such as ENCODE and Roadmap Epigenomics. Using this unsupervised approach we predict tissue-specific functional effects for every position in the human genome. We demonstrate the usefulness of our predictions using several validation experiments. Using eQTL data from several sources, including the Genotype-Tissue Expression project, the Geuvadis project and Twin-sUK cohort, we show that eQTLs in specific tissues tend to be most enriched among the predicted functional variants in relevant tissues in Roadmap. We further show how these integrated functional scores can be used to derive the most likely cell/tissue type causally implicated for a complex trait using summary statistics from genome-wide association studies, and estimate a tissue-based correlation matrix of various complex traits. We find large enrichment of heritability in functional components of relevant tissues for various complex traits, with FUN-LDA yielding the highest enrichment estimates relative to existing methods. Finally, using experimentally validated functional variants from the literature and variants possibly implicated in disease by previous studies, we rigorously compare FUN-LDA to state-of-the-art functional annotation methods such as GenoSky-line, ChromHMM, Segway, and IDEAS, and show that FUN-LDA has better prediction accuracy and higher resolution compared to these methods. In summary, we describe a new approach and perform rigorous comparisons with the most commonly used functional annotation methods, providing a valuable resource for the community interested in the functional annotation of noncoding variants. Scores for each position in the human genome and for each ENCODE/Roadmap tissue are available from http://www.columbia. edu/~ii2135/funlda.html.
In vivo binding and antitumor activity of Ch14.18.

The melanoma reactive chimeric 14.18 (ch14.18) antibody can mediate enhanced in vitro lysis of human M-21 melanoma cells. This study analyzes the antitumor effects and the in vivo binding of ch14.18 antibody with M-21 melanoma cells in severe combined immunodeficiency (SCID) mice. Outgrowth of tumors was prevented in 6/6 animals by the simultaneous subcutaneous injection of peripheral blood mononuclear cells (PBMC) [3 x 10(6) cells (2 animals); 10 x 10(6) cells (2 animals); and 30 x 10(6) cells (2 animals)], with 0.5 mg ch14.18, 1,500 U interleukin 2 (IL-2), and 10(6) M-21 cells. In contrast, 7 of 7 control mice that received M-21 cells alone, 7 of 7 mice that received M-21 cells and ch14.18, and 5 of 6 mice that received M-21 cells plus PBMC plus IL-2, grew subcutaneous tumors. The in vivo localization of ch14.18 was then evaluated in an intraperitoneal (i.p.) tumor model, where 0.3 cm melanoma nodules develop within 3 weeks after the i.p. administration of M-21 cells. Flow cytometric and immunohistochemical analysis revealed the GD2 antigen present throughout the tumor nodule. Intraperitoneal administration of 0.01, 0.1, or 1.0 mg of ch14.18 to SCID mice previously engrafted i.p. with M-21 cells resulted in detectable ch14.18 binding to tumor cells in vivo within 10 hours of antibody administration. Ch14.18 penetration was limited to approximately 20 cell layers, demonstrating that ch14.18 has limited access to some cells in large tumor nodules. This study demonstrates that the addition of ch14.18 to IL-2 and human effector cells can result in significant antitumor activity by preventing the establishment of tumor nodules. These results suggest that clinical testing of IL-2 plus ch14.18 might be most effective if used in the setting of microscopic residual disease. Therapies that enhance ch14.18 penetration into tumor nodules should be evaluated with ch14.18 for patients with advanced melanoma.
The Deconsolidation of Democracy in East‑Central Europe: The New World Order and the EU’s Geopolitical Crisis

Abstract In recent decades, the most remarkable feature of East-Central European (ECE) states has been their engagement in a deconsolidation process that necessitates the reconceptualising of European Studies and the theory of democracy. In the early ’90s, during the “revolution of high expectations,” consolidation was the key term in the conceptual framework of the transitology paradigm, but this approach was questioned increasingly in the 2000s and rejected in the 2010s. In its place, deconsolidation was introduced as one of a wide array of similar terms referring to the decline, backsliding or regression of democracy and later as one of a whole “other” family of opposite terms like (semi-)authoritarian system and competitive/elected autocracy. Indeed, rather than a transition to democracy, a tendency to transition to authoritarian rule has been observed in the ECE states in general and in Poland and Hungary in particular. In the last quarter century, the twin terms of Europeanisation and democratisation, which denote normative approaches, have been the main conceptual pillars of analyses of the ECE states. It turns out, however, that the opposite processes of de-Europeanisation and de-democratisation can now also be observed in these countries.
Elastase inhibitor elafin is a new type of proteinase inhibitor which has a transglutaminase-mediated anchoring sequence termed "cementoin".

Elafin was shown to be a new type of proteinase inhibitor which has an anchoring sequence. Human elafin, a potent inhibitor specific for elastase and proteinase 3, has a unique repeating sequence in its prosegment that is rich in Gln and Lys residues. The prosegment, termed "cementoin," exhibits high homology with the repetitive element of seminal vesicle clotting protein, which is known as a good substrate for prostate transglutaminase. The cross-linking of cementoin by tissue transglutaminase showed that the cementoin moiety is indeed a preferable substrate for transglutaminase. In addition, transglutaminase-mediated cross-linking between cementoin and laminin was observed in vitro, suggesting that cementoin has the ability to covalently attach to other extracellular matrix proteins. To determine whether or not this type of covalent gluing of elafin through the cementoin moiety occurs in vivo, we determined the molecular size of cementoin-elafin in the trachea mucous epithelium by Western blotting; the rationale of this approach is that (i) the trachea is the richest source of cementoin-elafin, as shown below, and (ii) if cementoin-elafin is covalently associated with other proteins, it should migrate as a higher M(r) species on SDS-polyacrylamide gel electrophoresis; cementoin-elafin immunoreactivity was indeed detected at a position corresponding to 50 kDa, a value much higher than that of its monomeric form. RNase protection analysis and immunohistochemical staining revealed that cementoin-elafin is densely distributed in the skin and trachea, and moderately in the stomach, duodenum and small intestine. These sites of localization are consistent with the locations where elastic fibers are abundant. (ABSTRACT TRUNCATED AT 250 WORDS)
Sufficient Conditions for Efficient Classical Simulation of Quantum Optics

We provide general sufficient conditions for the efficient classical simulation of quantum-optics experiments that involve inputting states to a quantum process and making measurements at the output. The first condition is based on the negativity of phase-space quasiprobability distributions (PQDs) of the output state of the process and the output measurements; the second one is based on the negativity of PQDs of the input states, the output measurements, and the transition function associated with the process. We show that these conditions provide useful practical tools for investigating the effects of imperfections in implementations of boson sampling. In particular, we apply our formalism to boson-sampling experiments that use single-photon or spontaneous-parametric-down-conversion sources and on-off photodetectors. Considering simple models for loss and noise, we show that above some threshold for the probability of random counts in the photodetectors, these boson-sampling experiments are classically simulatable. We identify mode mismatching as the major source of error contributing to random counts and suggest that this is the chief challenge for implementations of boson sampling of interesting size.
A Systematic Review of Early Warning Systems’ Effects on Nurses’ Clinical Performance and Adverse Events Among Deteriorating Ward Patients

Objective Early warning systems (EWSs) are an integral part of processes that aim to improve the early identification and management of deteriorating patients in general wards. However, the widespread implementation of these systems has not generated robust data regarding nurses’ clinical performance and patients’ adverse events. This review aimed to determine the ability of EWSs to improve nurses’ clinical performance and prevent adverse events among deteriorating ward patients. Method The PubMed, CINAHL, EMBASE, and Cochrane Library databases were searched for relevant publications (January 1, 1997, to April 12, 2017). In addition, a grey literature search evaluated several guideline Web sites. The main outcome measures were nurses’ clinical performance (vital sign monitoring and rapid response team notification) and patients’ adverse events (in-hospital mortality, cardiac arrest, and unplanned intensive care unit [ICU] admission). Results The search identified 888 reports, although only five studies fulfilled the inclusion criteria. The findings of these studies revealed that EWSs implementation had a positive effect on nurses’ clinical performance, based on their frequency of documenting vital signs that were related to the patient’s clinical deterioration. In addition, postimplementation reductions were identified for cardiac arrest, unplanned ICU admission, and unexpected death. Conclusions It seems that EWSs can improve nurses’ clinical performance and prevent adverse events (e.g., in-hospital mortality, unplanned ICU admission, and cardiac arrest) among deteriorating ward patients. However, additional high-quality evidence is needed to more comprehensively evaluate the effects of EWSs on these outcomes.
Identification of candidate Drosophila olfactory receptors from genomic DNA sequence.

We have taken advantage of the availability of a large amount of Drosophila genomic DNA sequence in the Berkeley Drosophila Genome Project database ( approximately 1/5 of the genome) to identify a family of novel seven transmembrane domain encoding genes that are putative Drosophila olfactory receptors. Members of the family are expressed in distinct subsets of olfactory neurons, and certain family members are restricted to distinct portions of the olfactory system. This pattern of expression has interesting similarities to and differences from the expression patterns observed for olfactory receptors in vertebrates. The Drosophila olfactory system is simpler than mammalian systems, yet it is complex enough to present a fascinating system in which to study neural information processing. Moreover, the powerful genetic manipulations available in Drosophila, when combined with electrophysiological and behavioral analyses, make this an attractive model system in which to study olfactory discrimination.