Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of combined exposure to anti-androgens on development and sexual dimorphic behaviour in rats

s, proceedings og præsentationer fra konferencer i 2009 29. -30. januar: The Second Copenhagen Workshop on DNA oxidation. Abstracts. http://www.rigshospitalet. dk/menu/AFDELINGER/Diagnostisk+center/Klinisk+Farmakologisk+Laboratorium/DNAox2/Copenhagen2/Presentations/ 10. -12. marts: Climate Change: Global Risks, Challenges & Decisions, København. Abstracts. http://www.iop. org/EJ/volume/1755-1315/6 25. -27. marts: Harmonising Biobank Research: Maximising Value – Maximising Use, Bruxelles, Belgien. Conference Report http://www.phoebe-eu.org/eway/default.aspx? pid=271&trg=Content:_5687&Content:_5687=5717:17383::0:5697:1:::0:0 30. marts: Seminar om klimatilpasning, København. Presentations. http://www.klimatilpasning. dk/da-DK/Service/seminar/Sider/Forside.aspx 6. –7. maj: Bernstein Symposium: Air Toxics: Transcending Boundaries, Ann Arbor, Michigan, USA. Proceedings. http://www.sph. umich.edu/riskcenter/09symposium/agenda.htm 12. -15. maj: XXIX International Congress of the European Association of Poisons Centres and Clinical Toxicologists, Stockholm, Sverige Abstracts. http://www.eapcct. org/publicfile.php? folder=congress&file=Abstracts_Stockholm. pdf 4. -5. juni: First Lorenzo Tomatis Conference on Environment and Cancer, Torino, Italien. Presentations. http://www.ecnis. org/index.php? option=com_content&task=view&id=1072&Itemid=83
Energy-Area Aware Channel Design for Multi-Chip Interfaces

Multi-chip communication interfaces on an interposer or a package substrate must consume minimum routing area while consuming low power in the transceiver blocks. This paper presents an algorithm to design this channel in view of energy and area metrics for a given transceiver topology. It is then show-cased using an example of silicon interposers.
Something new from the South: community, work, and family in South Africa

ABSTRACT The relationships that hold community, work, and family together are globally diverse. This complexity is not always acknowledged, and the importance of local context and understandings are often missed. For the field to advance, new perspectives must be welcomed as they will shift boundary conditions of what is positioned as privileged. This will open space not only to add empirical richness but invites theoretical innovation. This paper draws on emerging theory from the global South. Southern theory holds the promise of new ways of understanding community, work, and family, not just as an add-on where Southern examples are provided. Taking account of global knowledge inequalities that have occasionally marginalised perspectives from the periphery, we can now develop new research agendas, new concepts and lexicons, and reframe research questions. These may disrupt what is currently assumed to be the status quo and provide scope for fresh questions and new answers. Putting Southern theory into practice in my own research on supporting breastfeeding at work among low-income mothers in South Africa, helped to emphasise the salience of context. I suggest an agenda for community, work, and family research that gives emphasis to the importance of location and the inequalities in knowledge production.
Experimental Verification of a Ultra-Low Voltage Charge Pump

This paper deals with the analysis of a cross coupled charge pump designed in a 130 nm CMOS technology with ultra low power supply voltage. We propose a printed circuit board, designed to experimentally verify this integrated circuit. The test board was designed to verify all function blocks of the charge pump independently, as well as the charge pump circuit as a whole. The charge pump was designed to operate at a supply voltage of 200 mV and the switching frequency of 100 kHz. The achieved experimental results prove the correct functionality of the designed charge pump integrated circuit.
Comparing the performance of ResNets on COVID-19 diagnosis using CT scans

To the date, the Coronavirus disease 2019 (COVID-19) is still spreading around the world. Reverse transcription polymerase chain reaction (RT-PCR), which is regarded as the gold standard by the anti-epidemic front. Unfortunately, due to its lack of sensitivity (only 60%~71%), unstability, long processing time, some alternative diagnostic tools including computed tomography (CT) have been developed using convolutional neural networks (CNNs). This paper retrospectively collected 3227 CT scans (including 1601 COVID-19 positive and 1626 negative samples), on which ResNet-18 outperforms all three classical ResNets with the precision of 0.971, accuracy of 0.943, F1 of 0.942, sensitivity of 0.914, specificity of 0.973 and AUC of 0.985 respectively. Finally, the visualization technique classification activation map (CAM) was applied for lesions localization.
Root system response of selected lowland Thai rice varieties as affected by cultivation method and potassium rate under alternate wetting and drying irrigation

ABSTRACT Root system is an important factor for crop productivity under water- and nutrient-limited environments. A pot study was conducted to evaluate root system response of three Thai rice varieties (Pathumthani 1, RD57, RD41) under three cultivation methods (dry direct seeding [DDS], wet direct seeding [WDS], transplanting [TP]) and three levels of alternate wetting and drying irrigation (–5, –15, –30 kPa). A second pot experiment examined the effect of potassium (K) rates (0, 80, 120, 160 kg ha–1) on root system response of the same varieties under DDS and TP subjected to alternate wetting and drying at –5 kPa. Pathumthani 1 was more tolerant to moisture stress; RD57 and RD41 showed an inconsistent response to moisture-deficit conditions. Rice plant under TP was more sensitive to moisture stress; rice plant performed better under DDS even at the highest soil moisture stress of –30 kPa. K application at the rate of 120 kg ha–1 as basal under DDS was optimum for root system development of Pathumthani 1, while RD57 and RD41 had higher actual root length at the same K rate regardless of cultivation methods. Alternate wetting and drying up to –30 kPa could be safely applied for the three tested varieties. The performance of root system of Pathumthani 1 was better under DDS method of cultivation. K fertilization at 120 kg ha–1 can be recommended as optimum rate under water-saving cultivation techniques for the three tested varieties.
Development of a Mecanum-Wheeled Mobile Robot for Dynamic- and Static-Obstacle Avoidance Based on Laser Range Sensor

This study aims to present an idea about the practical consequences of using mobile robots with Mecanum wheels. For mobile robots, an approach is proposed to avoid obstacles without location and map information. This approach is presented using a series of developed solutions. This article shares the process on how a set of discussed conceptual methodologies can be applied as well as their practical results. This method is provided using fuzzy logic and gap tracking. LIDAR is used to recognize obstacles around the mobile robot. By using the LIDAR, the robot detects gaps around it and moves according to fuzzy logic. The fuzzy logic consists of three inputs, an output, and 45 rules. The ﬁrst of the membership functions represents the membership function that replaces the obstacle. The second membership function calculates the distance to the obstacle. The ﬁnal login membership function is used to determine the angle between the obstacle and robot view. The output membership function represents the membership function that moves the robot. The results are analyzed under three different scenarios with ﬁve different experiments for each scenario. The results show that the mobile robot can avoid obstacles without location and map information. We believe that the proposed method can be used in mobile robots such as guard and service robots.
A novel approach for particle swarm optimization‐based clustering with dual sink mobility in wireless sensor network

The proliferation in the sensing technology in wireless sensor network has left an everlasting impact to revolutionize every sector of human's lives. The limited battery of sensor nodes (SNs) has generated a tremendous challenge for the researchers to ameliorate the network's life span. To pacify this concern, in this paper, we have proposed a particle swarm optimization (PSO)‐based dual sink mobility (PSODSM) technique to reduce the energy expenditure of the SNs. PSODSM has the paramount focus on the cluster head (CH) selection based on integration of crucial factors: “ratio of remaining energy to the initial energy,” node degree, node centrality, separation factor between the SN and the sink, CH number, and energy consumption rate. As soon as the CHs are selected, two sinks placed opposite to each other are made to move towards the selected CHs for data collection. The most prominent fact is the movement of sinks which is done outside the periphery of the network to collect data rather than the reported conventional research works that employ sink mobility inside the network. Extensive simulations are performed to examine the empirical evaluation of PSODSM based on the benchmark of different performance metrics. The performance validation of PSODSM is done against the other meta‐heuristic algorithms, and findings show that the PSODSM outperforms the competitive algorithms and is also found to be scalable pertaining to real time implementation.
Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health

Infection with hepatitis E virus (HEV) represents the most common source of viral hepatitis globally. Although infecting over 20 million people annually in endemic regions, with major outbreaks described since the 1950s, hepatitis E remains an underestimated disease. This review gives a current view of the global circulation and epidemiology of this emerging virus. The history of HEV, from the first reported enteric non-A non-B hepatitis outbreaks, to the discovery of the viral agent and the molecular characterization of the different human pathogenic genotypes, is discussed. Furthermore, the current state of research regarding the virology of HEV is critically assessed, and the challenges towards prevention and diagnosis, as well as clinical risks of the disease described. Together, these points aim to underline the significant impact of hepatitis E on global health and the need for further in-depth research to better understand the pathophysiology and its role in the complex disease manifestations of HEV infection.
Imlifidase Desensitization in Crossmatch-positive, Highly Sensitized Kidney Transplant Recipients: Results of an International Phase 2 Trial (Highdes)

Supplemental Digital Content is available in the text. Background. Highly HLA sensitized patients have limited access to life-saving kidney transplantation because of a paucity of immunologically suitable donors. Imlifidase is a cysteine protease that cleaves IgG leading to a rapid decrease in antibody level and inhibition of IgG-mediated injury. This study investigates the efficacy and safety of imlifidase in converting a positive crossmatch test to negative, allowing highly sensitized patients to be transplanted with a living or deceased donor kidney. Methods. This open-label, single-arm, phase 2 trial conducted at 5 transplant centers, evaluated the ability of imlifidase to create a negative crossmatch test within 24 h. Secondary endpoints included postimlifidase donor-specific antibody levels compared with predose levels, renal function, and pharmacokinetic/pharmacodynamic profiles. Safety endpoints included adverse events and immunogenicity profile. Results. Of the transplanted patients, 89.5% demonstrated conversion of baseline positive crossmatch to negative within 24 h after imlifidase treatment. Donor-specific antibodies most often rebounded 3–14 d postimlifidase dose, with substantial interpatient variability. Patient survival was 100% with graft survival of 88.9% at 6 mo. With this, 38.9% had early biopsy proven antibody–mediated rejection with onset 2–19 d posttransplantation. Serum IgG levels began to normalize after ~3–7 d posttransplantation. Antidrug antibody levels were consistent with previous studies. Seven adverse events in 6 patients were classified as possibly or probably related to treatment and were mild-moderate in severity. Conclusions. Imlifidase was well tolerated, converted positive crossmatches to negative, and enabled patients with a median calculated panel-reactive antibody of 99.83% to undergo kidney transplantation resulting in good kidney function and graft survival at 6 mo.
Blood hormone profiles, physiological variables, and behavioral criteria in Corriedale ewes fed different TMR moisture levels during thermal–humidity exposure

Abstract In this study, blood hormone profiles, physiological variables, and behavioral criteria in Corriedale ewes fed total mixed ration (TMR) at different moisture levels during thermal–humidity exposure were evaluated. Nine non-pregnant Corriedale ewes (ave. BW = 41 ± 3.5 kg) were individually fed diets based on maintenance requirements in metabolic crates. Ewes were assigned to three treatment groups according to a 3 × 3 Latin Square design for 3 periods of 21 days duration each (9 ewes per treatment). Treatments were TMR (CP (crude protein) = 16.1, TDN (total digestible nutrients) = 69.1%) moisture levels at 40, 50, and 60%. No differences were found in blood hormone profiles including cortisol (μg/dL), immunoglobulin G (mg/dL), triiodothyronine (ng/mL), thyroxin (μg/dL), growth hormone (ng/mL), prolactin (ng/mL), insulin (μU/mL), insulin-like growth factor 1 (ng/mL), aldostrone (ng/dL), antidiuretic hormone (pg/mL), and creatinine (mg/dL) among all treatment groups (p > 0.05). Measurements of physiological variables indicated that heart rate (number of beats/min) in the afternoon was higher in 50 and 60% TMR group than in the 40% group (p < 0.05). No differences were observed in respiratory rate (number/min), panting score, and fecal score among the groups (p > 0.05). The behavior criteria including urine excretion frequency (number/d), fecal excretion frequency (number/d), standing frequency (number/d), resting frequency (number/d), standing duration (min/d), and resting duration (min/d) showed no differences among the treatment groups (p > 0.05). Conclusions drawn indicate the minor impacts of TMR moisture levels up to 60% on behavioral criterions of Corriedale ewes during thermal–humidity exposure, but help smooth down the intensified heat stress conditions over physiological variables and endocrine system.
Anti-stress Properties of Atypical Antipsychotics

Stress exposure represents a major environmental risk factor for schizophrenia and other psychiatric disorders, as it plays a pivotal role in the etiology as well as in the manifestation of disease symptomatology. It may be inferred that pharmacological treatments must be able to modulate the behavioral, functional, and molecular alterations produced by stress exposure to achieve significant clinical outcomes. This review aims at examining existing clinical and preclinical evidence that supports the ability of atypical antipsychotic drugs (AAPDs) to modulate stress-related alterations. Indeed, while the pharmacodynamic differences between AAPDs have been extensively characterized, less is known on their ability to regulate downstream mechanisms that are critical for functional recovery and patient stabilization. We will discuss stress-related mechanisms, spanning from neuroendocrine function to inflammation and neuronal plasticity, which are relevant for the manifestation of schizophrenic symptomatology, and we will discuss if and how AAPDs may interfere with such mechanisms. Considering the impact of stress in everyday life, we believe that a better understanding of the potential effects of AAPDs on stress-related mechanisms may provide novel and important insights for improving therapeutic strategies aimed at promoting coping mechanisms and enhancing the quality of life of patients affected by psychiatric disorders.
Dual pathology in a patient with temporal lobe epilepsy associated with neocortical glial scar after brain abscess and end folium sclerosis/hippocampal sclerosis type 3

End folium sclerosis or hippocampal sclerosis (HS) type 3 is often associated with another coexisting epileptogenic lesion (dual pathology); however, the pathogenesis of HS type 3 remains elusive. A 46‐year‐old man presented with medically intractable focal aware seizures and focal impaired awareness seizures (FIAS) with occasional focal to bilateral tonic–clonic seizures (FBTCS) two years after surgical treatment with extensive cranial reconstruction for a brain abscess in the right temporal lobe associated with intracranial extension of ipsilateral cholesteatoma. Head magnetic resonance imaging (MRI) at age 49 revealed atrophy of the right cerebral hemisphere including the hippocampus and amygdala. The patient's first epilepsy surgery was a lateral temporal lobectomy, in which the mesial temporal structures were preserved because no epileptiform discharge was detected on the intraoperative electrocorticogram. However, FIAS with FBTCS started 15 months after the operation. The second surgery, amygdalohippocampectomy, at age 52, resulted in the patient being seizure‐free again for one year before seizures of the right lateral temporal origin recurred. He underwent a third surgery, resection of the Heschl's and supramarginal gyri, at age 53, but he continued to have drug‐resistant epilepsy over two years after that. Histopathological examination revealed dual pathology consisting of glial scar in the lateral temporal lobe and ipsilateral HS type 3 with an unusually severe lesion in the subiculum. No significant inflammatory change was observed. The clinicopathological features in the present case indicate that HS developed secondarily in the context of neocortical epilepsy due to glial scar, suggesting a role of repetitive abnormal electrical input from neocortical epileptogenic lesions into the hippocampus finally via the perforant pathway in the pathogenesis of HS type 3. Severe hippocampal atrophy on preoperative MRI together with its silent electrocorticogram recording at initial epilepsy surgery may represent clinically pre‐epileptogenic HS in a seizure‐free “silent or latent period” before completion of hippocampal epileptogenesis to the extent that clinical epileptic seizures occur.
Memory suppression and its deficiency in psychological disorders: A focused meta-analysis.

It is still debated whether suppressing the retrieval of unwanted memories causes forgetting and whether this constitutes a beneficial mechanism. To shed light on these 2 questions, we scrutinize the evidence for such suppression-induced forgetting (SIF) and examine whether it is deficient in psychological disorders characterized by intrusive thoughts. Specifically, we performed a focused meta-analysis of studies that have used the think/no-think procedure to test SIF in individuals either affected by psychological disorders or exhibiting high scores on related traits. Overall, across 96 effects from 25 studies, we found that avoiding retrieval leads to significant forgetting in healthy individuals, with a small to moderate effect size (0.28, 95% CI [0.14, 0.43]). Importantly, this effect was indeed larger than for more anxious (-0.21, 95% CI [-0.41, -0.02]) or depressed individuals (0.05, 95% CI [-0.19, 0.29])-though estimates for the healthy may be inflated by publication bias. In contrast, individuals with a stronger repressive coping style showed greater SIF (0.42, 95% CI [0.32, 0.52]). Furthermore, moderator analyses revealed that SIF varied with the exact suppression mechanism that participants were instructed to engage. For healthy individuals, the effect sizes were considerably larger when instructions induced specific mechanisms of direct retrieval suppression or thought substitution than when they were unspecific. These results suggest that intact suppression-induced forgetting is a hallmark of psychological well-being, and that inducing more specific suppression mechanisms fosters voluntary forgetting. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Ianalumab (VAY736) in primary Sjögren's syndrome: assessing disease activity using multi-modal ultrasound.

OBJECTIVES To apply serial ultrasound (US) assessments to show effects of ianalumab (anti-BAFF-R monoclonal antibody) on inflamed salivary glands of patients with primary Sjögren's syndrome (pSS). METHODS In a single-centre, 24-week double-blind study (NCT02149420), 27 pSS patients of moderate-to-severe activity were randomly assigned to receive a single i.v. dose of either 3 mg/kg or 10 mg/kg ianalumab, or placebo. Concurrent with clinical and laboratory outcomes, multi-modal US images were acquired of bilateral parotid glands (PG) and submandibular glands (SMG) at weeks 0, 6, 12, and 24. Applied US modalities included 1) B-mode echostructure scored by de Vita classification, 2) macrovascular blood flow by power Doppler, and in PG only 3) microvascularisation using contrast-enhanced US (area under the curve, time to peak or TTP) and 4) gland stiffness by sonoelastography. RESULTS Clinical study results were previously published. US data for PG differed from SMG but were comparable between respective left and right sides of these glands. Numerical improvements in salivary gland quality and declining tissue inflammation were observed in treated versus placebo groups, including more patients achieving ≥1-point reduction from baseline in De Vita score, together with trends towards decreased perfusion and stiffness. Correlations between clinical endpoints and US parameters were largely restricted to microvascular perfusion TTP and at the 12-week timepoint when ianalumab effects were predicted at maximal. CONCLUSIONS Early in vivo signs of salivary gland improvement in response to an effective intervention can be shown without need of biopsy by using a non-invasive, comprehensive, ultrasound-based approach over multiple time points.
Virtual Antenna Array and Multipath AOA-Delay Fingerprints Based Location for Moving Targets

Multipath effects are the major challenge to the accurate indoor wireless positioning technology and the most viable solutions for overcoming such multipath effects are received signal strength (RSS) or channel status information (CSI) based fingerprinting location methods. However, these fingerprinting methods are usually subject to the RSS/CSI fingerprints’ high variability over space. In this paper, a novel virtual antenna array and multipath angle of arrival (AOA)-delay fingerprints based location method has been proposed. The proposed method employs 2-dimensional inverse Fourier transform on the CFRs (Channel Frequency Responses) at equi-spaced positions on a quasi-straight line moving trajectory, i.e., the CFRs of a virtual uniform linear array (VULA), to extract the equivalent multipaths’ AOAs and delays as the radio fingerprints, which vary much more slowly than the RSS/CSI fingerprints in the space domain. By exploiting the geometric properties of the multipaths’ AOAs and delays, a complete fingerprint database containing fingerprints of moving trajectories in different directions with each RP (reference position) as their midpoints can be constructed based on just two fingerprints of two perpendicular line trajectories with the same RP as the midpoints. Further, a two-step online fingerprinting location method is developed, the multipath delay estimates are used to narrow the scope of positioning in the first step, a modified WKNN (Weighed K-Nearest Neighbors) fingerprinting method, with the reciprocals of the fingerprints’ Euclidean distances adopted as the weighting factors, is then employed on RPs in such a narrowed positioning scope to enhance the positioning accuracy. Experimental results verify that the proposed fingerprinting method outperforms the corresponding traditional RSS/CSI fingerprints based approach.