Miracle-dz/UniFAR-FTUs huggingface dataset:
THE BENEFITS OF GARLIC (Allium sativum) AS ANTIHYPERTENSION

Abstract One in three adults suffers from hypertension. Hypertension is a condition when the blood pressure is higher than 140/90 mmHg after two separate measurements. Hypertension carries risk for other diseases, such as heart attack, stroke, and kidney failure; this disease contributes for 40% of cardiovascular death. Garlic (Allium sativum) is often used in various herbal remedies. Garlic contains allicin from alliin and allinase enzyme which has the effect of inhibiting angiotensin II and vasodilation. There are also studies say that garlic role in lowering blood pressure associated with the production of hydrogen sulfide which can mediate vasoactive. Medical research on garlic continues, especially on its antihypertension effect. Keywords : allicin , Allium sativum, garlic, hypertension Abstrak Saat ini satu dari tiga orang dewasa di dunia menderita hipertensi.Hipertensi adalah suatu keadaan tekanan darah lebih dari 140/90 mmHg setelah dua kali pengukuran terpisah. Hipertensi dapat meningkatkan risiko berbagai penyakit lain, seperti serangan jantung, stroke, dan gagal ginjal, dan menjadi penyebab 40% kematian akibat kardiovaskular. Garlic ( Allium sativum ) atau bawang putih, sering digunakan dalam berbagai pengobatan herbal.Bawang putih mengandung allicin yang berasal dari alliin dan enzim allinase yang memiliki efek menghambat angiotensin II dan vasodilatasi.Ada juga penelitian yang menyatakan bawang putih berperan dalam menurunkan tekanan darah terkait dengan produksi hidrogen sulfida, di mana hidrogen sulfida dapat memediasi vasoaktif.Penelitian medis garlic terus dilakukan, terutama efek antihipertensinya. Kata kunci: allicin, Allium sativum, garlic ,hipertensi
The Cataract‐associated RNA‐Binding Protein Celf1 Post‐transcriptionally Regulates the Key Eye Transcription Factor Pax6

The lens is a transparent tissue that focuses light on the retina allowing high‐resolution vision. Loss of lens transparency is defined as cataract, the leading cause of blindness worldwide. An estimated 25–50% of congenital cataract cases arise from underlying genetic alterations, making it important to characterize cataract‐linked genes and their pathological mechanisms.
Modified method of conductometric data analysis to calculate the conductivity of surfactant ions

Methodology for simple analytical refinement of the equivalent electrical conductivities of surfactant ions and counterions was proposed in the framework of the Debye – Hückel – Onsager theory as applied to surfactant dispersions at various concentrations. The developed methodology is based on the use of the mathematical form for the concentration dependencies of the specific conductivity in the premicellar region and makes it possible to calculate the equivalent conductivities of surfactant ions both under infinite dilution conditions and near the CMC. One of the advantages of the described method is the possibility of calculating the ion conductivities in the presence of a minimum number of experimental points (formally, a straight line can be constructed and its tangent of the angle of inclination can be determined even by two points corresponding to region 0.2 CMC — 0.8 CMC). Using the values of the equivalent conductivities of surfactant ions and counterions calculated for the required concentrations, allows to determine the parameters of the solution more accurately, including the contribution of micelles to the total conductivity of the solution.
Experiencia clínica en un hospital del sector privado con el uso de la cápsula endoscópica

INTRODUCTION AND OBJECTIVES Capsule endoscopy constitutes a non invasive method used for direct observation of the small bowel's mucosae and for recognizing possible injuries in it, such as the causes of obscure gastrointestinal hemorrhage and inflammatory diseases, for instance. The present study shows the experience obtained in a private hospital using capsule endoscopy for evaluating diverse intestinal pathologies. MATERIALS AND METHODS Ambulatory patients were evaluated, and the results analyzed in a retrospective, observational and transverse manner. The Given Imaging PillCam was used in all cases. RESULTS Forty five cases were evaluated; 27 of them (60%) were female, 18 were male (40%). The mean age was 58.16, ranging from 18 to 84 years. Obscure gastrointestinal bleeding constituted the most common indication for undergoing capsule endoscopy; present in 32 patients (71.11% of the cases). Other indications were: chronic diarrhea 5 cases (11.11%), abdominal pain 3 cases (6.67%) and melena 3 cases (6.67%). 18 cases presented no anomaly (40%). The most frequent pathological findings were: erosions 10 cases (22.20%), vascular disorders 8 cases (17.76%) and polyps 6 cases (13.32%). No complications were presented during or after the procedures, although in two of the cases the capsule had to be inserted under endoscopic assistance with sedation. CONCLUSIONS Capsule endoscopy is an innocuous, safe method, useful in identifying causes of obscure gastrointestinal bleeding, which is the most common indication for the study, and in identifying diverse small bowel pathologies.
Nursing care and religiosity on a hospital ward in Ghana

Looking at care delivery in hospital settings worldwide, it is the work of nurses that appears most prominent. While this is true in a general sense, it is important to realize the impact of cultural norms and social perceptions on the variety and differences in care giving. This paper explores the notion of care and religion on a medical ward in a Ghanaian teaching hospital. Analyzing the daily routine on the ward, it shows how medical nurses deal with the challenges put before them and how religion must be considered as an important element of the working routine in understanding the notion of care in the hospital setting. Both nurses–and patients subscribe to a set of cultural norms; they base their expectations and decisions on a mixture of professional formation, traditional heritage and individual background. Since the beginning of nursing in Ghana, the Christian belief influenced and transported a certain image of the nurse and woman in general. Religion plays an important role; it shapes perspectives, offers possible reactions to disease and death and influences social behaviour. This paper shows that the hospital is not a culturally-neutral biomedical institution but embedded in the Ghanaian culture. It is a place of medical treatment, social encounter and defined rituals.
Developing E- and Blended Learning Approaches for International Students

International students represent a large and increasing proportion of the undergraduate cohort, but tend to achieve lower grades than UK home students in many disciplines. This appears to reflect the challenge(s) of studying with lower level English skills, and acclimatising to an unfamiliar academic culture. Here we discuss the experience of designing supplementary e-learning materials and/or blended learning environments aimed at supporting these students, and outline how we evaluated their effectiveness.
Improvement of care in acute stroke units

1report on an innovative cluster trial of multidisciplinary team management of common acute stroke abnormalities in Australian acute stroke units (ASUs). Importantly, the trial not only focuses on appropriate management of fever, hyperglycaemia, and dysphagia, but also uses implementation science theory to maximise the chances of the intervention being sustainable in the longer term. The study randomised 19 metropolitan ASUs in New South Wales, Australia to standard care with access to abridged acute-care protocols, or care delivered by multidisciplinary teams with access to team building, site champions, and educational programmes. The intervention group achieved dramatically improved outcomes in terms of mortality and severe disability. Intervention ASU patients were signifi cantly less likely to be dead or dependent at 90 days than were control ASU patients (236 [42%] of 558 patients in the intervention group vs 259 [58%] of 449, p=0·002; adjusted absolute diff erence 15·7% [95% CI 5·8–25·4]). Patients in intervention ASUs had signifi cantly lower mean temperatures, lower mean glucose levels, and improved swallowing screening during the fi rst 72 h of admission to the ASU than did patients in control ASUs. Stroke unit care saves lives 2 and reduces long-term disability. 3 However, most trials of stroke units have assessed rehabili tation stroke units, with few assessing ASUs and none identifying how they might improve outcomes. The fi ndings from Middleton and colleagues 1
Quantitative Detection of human Cytomegalovirus DNA in pregnant women in Iraq using Real - time PCR

Human Cytomegalovirus (HCMV) infection stands as potential serious viral complication in pregnant women. It is also the most common cause of abortion during pregnancy. In this work, the detection of HCMV IgG and IgM antibodies in serum specimen from suspected patients was carried out by ELIZA. The results of serological investigation were compared to the results of Real time PCR based detection of the HCMV from serum samples to check the validity of this technique in the early diagnosis of the infection. Our investigation reviled that all the 46 patients were harboring the IgG antibodies against HCMV antigen where as 40 samples were carried HCMV IgM antibodies. On the other hand 25 patients were positively identified to be HCMV carrier as 21 samples of the serum was free from nucleic acid substance of the virus.
Mobile based primary health care system for rural India

Mobile technologies are increasingly growing in developing countries like India. There have been several new researches and developments in this space. Nowadays mobile is becoming an important ICT tool not only in urban regions but also in remote and rural areas. The rapid advancement in the technologies, ease of use and the falling costs of devices, make the mobile an appropriate and adaptable tool to bridge the digital divide. Mobile phone ownership in India is growing rapidly, six million new mobile subscriptions are added each month and one in five Indian's will own a phone by the end of 2007. By the end of 2008, three quarters of India's population will be covered by a mobile network. Many of these new "mobile citizens" live in poorer and more rural areas with scarce infrastructure and facilities, high illiteracy levels, low PC and internet penetration. The availability of low-cost mobile phones and the already broad coverage of GSM networks in India is a huge opportunity to provide services that would trigger development and improve people’s lives. This paper explores the present status of Mobile based Health Care systems in different countries, shortfalls in Primary Health Care Management in rural India, and the potential solution to fill it with the enabling of Mobile Web technologies for Primary Health Care management.
Volunteer Experience Related Changes in College Students as Mental Health Volunteers

This Dissertation is brought to you for free and open access by the Theses and Dissertations at Loyola eCommons. It has been accepted for inclusion in Dissertations by an authorized administrator of Loyola eCommons. For more information, please contact ecommons@luc.edu. other members of my Committee, for their help and cooperation. In addition, I would like to thank Steve Rivard, the volunteer rating scale used in this study. Special acknowledgment goes to all the undergraduates, both volunteers and non-volunteers, who agreed to be tested for my research: Finally, I wish to give my sincerest thanks to my husband Larry who not only gave me moral support but also helped me organize and program the data for computer analysis. Illinois. She graduated magna cum laude with a B.A. in psychology on January 1, 1969. She also was a member of the NCC Honor Society and was nominated for a Danforth Fellowship. In September, 1969, she began her graduate training in clinical psychology at Loyola University of Chicago. She received a U.S. Public Health Fellowship her first two years at Loyola University. She was the recipient of a Schmitt Doctoral Fellowship for the 1972-1973 school year. In 1970 she did a 500 hour clinical clerkship at the De Paul Uni-iii For the past two years Mrs. Kerschner has been employed at the Loyola University Guidance Center while completing the requirements for a doctorate degree in clinical psychology. She married Lawrence Kerschner in December, 1969. They currently have no children.
Rapid assessment of alcohol and other substance use in conflict-affected and displaced populations: A field guide

Reproduction and dissemination for educational or other non-commercial purposes is authorized without any prior written permission from the copyright holders provided the source is fully acknowledged. Reproduction for resale or other commercial purposes, or translation for any purpose, is prohibited without the written permission of the copyright holders. Applications for such permission should be addressed to the Public Health and HIV Section of the Office of the United Nations High Commissioner for Refugees (UNHCR) at hivaids@unhcr.org and the Department of Mental Health and Substance Abuse at the World Health Organization at msd@who.int All reasonable precautions have been taken by the United Nations High Commissioner for Refugees and the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the United Nations High Commissioner for Refugees or the World Health Organization be liable for damages arising from its use.
Medicaid's β2-Agonist Recipients and Their Treatment by National Standards

OBJECTIVE: To determine whether Connecticut's Medicaid high-dose β2-agonists (HDB) users (>1 canister/mo) are receiving medications according to National Institutes of Health (NIH) asthma guidelines, and to compare healthcare utilization between HDB users and patients receiving no more than one canister of a short-acting β2-agonist per month. METHODS: All Connecticut Medicaid pharmacy claims from April to December 1998 were examined. Subjects were included if they had an asthma diagnosis and were excluded if they had chronic obstructive pulmonary disease. The percentage of HDB users not receiving long-term-control medication; receiving low doses of a long-term-control medication; and receiving oral, nebulized, or long-acting β2-agonists was determined. Healthcare utilization between HDB users and patients receiving no more than one canister of a short-acting β2-agonist per month was also compared. RESULTS: Of 1599 profiles included, 14% (n = 223) were HDB users. Twenty-five percent of these patients did not receive a long-term-control medication, and 35% received low doses of a long-term-control medication. Claims for oral, nebulized, and long-acting β2-agonists were submitted for 4%, 29%, and 22% of HDB users, respectively. More claims for short courses of oral corticosteroids were submitted for HDB users than for patients receiving no more than one canister of a short-acting β2-agonist per month (n = 1376) (1.99 ± 3.60 vs. 0.39 ± 1.07 mean ± SD; p < 0.001). HDB users visited their physicians' offices an average of 4.72 ± 24.08 × per month compared with an average of 2.40 ± 14.4 office visits per month for patients receiving no more than one canister of a short-acting β2-agonist (p = 0.04). CONCLUSIONS: A high proportion of Connecticut's Medicaid HDB users are not receiving medications according to NIH guidelines. HDB users were significantly more likely to receive short courses of oral corticosteroids and required significantly more office visits than patients receiving no more than one canister of a short-acting β2-agonist per month. Intervention programs designed to improve adherence to the guidelines will be developed.
Enhancement of PDT-cytotoxicity via ROS induced by indomethacin in metastatic breast cancer

Breast cancer is one of the most common types of cancers prevalent in women. Several types of breast cancers can easily metastasize to bone and cause disease complications such as hypercalcemia and pathologic fracture, thus compromising the quality of life of people affected by it. Bisphosphonate drugs are often used for the treatment of bone metastasis to suppress osteoclastic bone resorption. However, bisphosphonate has adverse effects on the gastrointestinal tract and kidneys and also induces osteonecrosis of the jaw. Photodynamic therapy (PDT) is an alternative cancer treatment approach with minimal invasiveness. It is a combination treatment that uses photosensitizers, which accumulate in tumor cells, followed by laser irradiation. We previously reported that the cellular incorporation of 5-aminolevulinic acid (5-ALA), which was a precursor of protoporphyrin IX (PpIX), was regulated by reactive oxygen species derived from mitochondria (mitROS). In this study, we investigated the incorporation of 5-ALA, accumulation of PpIX, and subsequent effects on cell viability after laser irradiation of two different breast cancer cell lines with different metastaticites. The highly metastatic breast cancer cell line 4T1E/M3 showed a significant increase in ROS production after treatment with indomethacin (IND). In addition, IND treatment enhanced the cellular uptake of 5-ALA via PEPT1 upregulation in 4T1E/M3, but not in the non-metastatic cell line. Overall, metastatic breast cancer is likely to be sensitive to ROS and activate signaling pathways associated with 5-ALA transportation, suggesting that ALA-PDT could be an effective treatment with low invasiveness for metastatic breast cancer.
Nicotinamide-Appended Fluorophores as Fluorescent Redox Sensors

Fluorescent sensors have proved invaluable in elucidating the regulation and dysregulation of redox processes in biology, but understanding of the breadth of biological redox reactions requires development of new sensors based on a range of sensing groups with varied reduction potentials. The aim of this work was to investigate the use of nicotinamide as a redox switch when conjugated to two classes of amino-fluorophores. We prepared four fluorophore conjugates based on 7-aminocoumarins and 4-amino-1,8-naphthalimides via the nicotinamide Zincke salt. These conjugates all showed clear fluorescence changes in response to chemical reduction, but this reduction was irreversible both chemically and electrochemically. The reduction behaviour of the 1,8-naphthalimides was investigated further by spectroelectrochemistry, revealing that conjugate NNpR1 showed the clearest spectral changes on both chemical and electrochemical reduction. Cells dosed with NNpR1 and maintained under hypoxic conditions exhibited a significantly higher green : blue fluorescence ratio than cells cultivated under normoxia, confirming the potential of this molecule as a sensor for reductive biological environments.
Amphiphilic macromolecule therapeutics to manage cardiovascular disease

96 Introduction . 97 Materials and methods . 101 Materials . 101 NP fabrication and characterization . 101 In vitro validation of NPs . 102 Animal care . 102 Administration of NPs . 103 Animal imaging and blood collection . 103 Animal euthanasia . 104 Gene expression . 104 NP cellular association and receptor expression using flow cytometry . 105 NP pharmacokinetcs . 105 Aorta tissue preparation for imaging and immunohistochemistry . 105 Image analysis . 106 Statistical analysis . 107 Results . 108
Profile of Modified Sorghum Flour Fermented by Lactobacillus Brevis

Lactobacillus brevis is an excellent species of lactic acid bacteria for improving functional and physicochemical properties of flour. The study aimed to characterize sorghum flour profiles modified using Lactobacillus brevis. Sorghum grains of a local variety KD4 was polished using a mini polisher. The flour was fermented with L.brevis at different concentrations. The experiment was designed in a completely randomized, two factors and three replications. The first factor was microbial concentrations (0.5; 0.10; 0.15; 0.20%) and the second factor was fermentation time (4, 8, and 12 hours). The results showed that the microbial concentrations and fermentation time affected the physicochemical properties of the flour such as starch content, amylose, bulk density, and whiteness degree of flour. Increasing the fermentation temperatures increased the swelling power of starch and resulted in high solubility of the granules. Sorghum starch solubility was influenced by amylose content. The longer the time of incubation, the lower the tannin content. Flour water absorption ranged from 11.58 to 21.81%, whereas oil absorption had no significant differences. The study suggests that L.brevis in a concentration of 0.20% and 12 hour of fermentation can be used in the fermentation of sorghum flour.
PERCEPTION OF QUALITY OF LIFE AND MENTAL HEALTH IN OFFICERS OF THE COLOMBIAN AIR FORCE

Due to internal public order situation in Colombia, officials of the Colombian Air Force (FAC) are exposed to potentially traumatic stressors. The objective of this study was to determine officials perception of their quality of life and its relationship with mental health in order to provide elements for discussion for the development of promotion and prevention programs. A correlational methodology was used; the sample was of 296 volunteer flight officers and 200 FAC non-flying officers from different locations from Colombia. Five aspects of quality of life (self-acceptance, adaptation, socio-affective stability, physical integrity and personal projection), three aspects of the quality of military life (recognition, institutional support and cohesion) and 6 indicators of psychopathology (depression, anxiety, mania, * Correspondencia: Luis Artemo Gonzalez luis.gonzalezq@unimilitar.edu.co. Direccion Correspondencia: Tr. 5 No 49-00, Facultad de Medicina, Universidad Militar Nueva Granada, Bogota, Colombia. Recibido: Agosto 2 de 2009 Aceptado: Septiembre 16 de 2009. Revista 18 (1): 115-122, 2010
Forecasting Surface O3 in Texas Urban Areas Using Random Forest and Generalized Additive Models

We developed and evaluated three types of statistical forecasting models (quantitative, probabilistic, and classification) for predicting the maximum daily 8-hour average concentration of ozone based on meteorological and ozone monitoring data for six Texas urban areas from 2009 to 2015. The quantitative and probabilistic forecasting models were generalized additive models (GAMs), whereas the classification forecast used the random forest machine learning method. We found that for the quantitative forecasting models, five of the eight predictors (the day of week, day of the year, water vapor density, wind speed, and previous day’s ozone measurement) were significant at the α = 0.001 level for all urban areas, whereas the other three varied in significance according to the location. The quantitative forecasting for the 2016 ozone season agreed well with the associated measurements (R2 of ~0.70), but it tended to under-predict the ozone level for the days with the highest concentrations. By contrast, the probabilistic forecasting models showed little accuracy in determining the probability of concentrations exceeding policy-relevant thresholds during this season. The success rate for the random forest classification models typically exceeded 75% and would likely increase if the training data sets contained more extreme events.
Synthesis and characterization of some polyfluorophenylorganoamidoplatinum(II) complexes and investigation the biological activity of these anticancer drugs with DNA and cells

This thesis describes the synthesis, characterization and anticancer activity of some novel organoamidoplatinum(II) complexes using Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy. It establishes the effect of these complexes as anticancer drugs after the interaction with isolated DNA and cancer cells.