Miracle-dz/UniFAR-FTUs huggingface dataset:
Broadband linearization of InGaP/GaAs HBT power amplifier

High linearity over a broad frequency band is a requirement in many RF amplifier designs. This paper shows that adding low impedance terminations at the envelope frequency (ω2−ω1) to the input of a Gallium Arsenide (GaAs) Heterojunction Bipolar Transistor (HBT) Distributed Amplifier (DA) improves the third order output intercept point (OIP3) over a bandwidth of 0.5 GHz to 3 GHz by up to 7.4 dB. Furthermore, OIP3 can be increased up to 19.2 dB above P1dB. Results show that the improvement in OIP3 comes without lowering gain, return loss or P1dB. Simulation and measurement results also show that the optimum termination is a short circuit with a small capacitive reactance at the envelope frequency. By varying the frequency spacing (Δ ω) from 1 MHz to 50 MHz, the resulting variation in OIP3 after the addition of the traps is less than 7%.
Magnetic Manipulation of a Microcantilever for a New Concept in Atomic Force Microscopy

Magnetic manipulation of a microcantilever for a new concept in atomic force microscopy, which is able to adjust the stiffness of microcantilever and do simultaneous imaging and manipulation of living cell, is presented. With the data of the appropriate magnetic force for operation, the magnetic elements are designed using a magnetic analysis program. The experimental results show that the design process is valid, and the precise manipulation of microcantilever is feasible
Evaluation of a Latex-Enhanced Immunoturbidimetric Assay for Measuring Low Concentrations of C-Reactive Protein

C-reactive protein (CRP) is one of the most sensitive acute phase reactants, with concentrations usually rising quickly after the onset of inflammation and returning to normal when the inflammation has subsided. A commonly assigned cut-off value for CRP is < 10mg/L, with concentrations of 10-40 rng/L being seen in mild inflammation and concentrations of40-200 rng/L being associated with acute inflammation and bacterial infection. ' In these situations, a cut-off value for indicating inflammatory change in patients has been found to be appropriate, especially as routine immunoturbidimetric assays lack the sensitivity to measure CRP in noninflammatory conditions. The reference interval for CRP in normal individuals, determined using a highly sensitive enzyme-linked immunosorbent assay (ELISA), has shown a skewed distribution of results, median 0·64 rng/L with a 0·95 interfractile interval of 0·08 to 3·11 mg/L? Recent studies have implicated higher CRP levels, even within this reference interval, in the development of atherosclerosis' and as an indicator of risk in patients with angina. " The introduction of latex-enhanced immunoturbidimetric assays for the measurement of CRP has been claimed to solve problems with sensitivity and should allow low concentrations of CRP to be measured on routine analysers, rather than by radioimmunoassay or ELISA techniques. We have adapted one of these commercially available assays for use on the Cobas Mira analyser and evaluated it for measuring CRP at low concentrations.
Force Discrimination Ability of the Human Hand near Absolute Threshold for the Design of Force Feedback Systems in Teleoperations

Force discrimination ability is an important surgical skill for micro or minimally invasive surgeries. This article analyzes the force perception of the human hand for lowintensity stimuli. Psychophysical experiments were conducted to measure just noticeable differences (JNDs) at four reference forces below 1 N. Reference forces are chosen to be in the range of forces in minimally invasive surgery that do not follow Weber's law. The force discrimination ability of two groups of subjects, surgeons and non-surgeons, is compared. Results demonstrate a superior ability of surgeons in discriminating small forces. The relationship between the JND and stimulus near absolute threshold is modeled. The application of the model in the design of force feedback systems for surgical teleoperation is discussed. In a force augmenting teleoperation system, the force feedback signal is amplified based on the characteristics of the human perception system. Therefore, the degraded human sense of touch at low-intensity forces would be compensated.
Molecular Cloning of a Putative Gastric Chitinase in the Toad Bufo japonicus

Abstract On the basis of our preliminary observation that a crude extract of the stomach of the toad Bufo japonicus exhibited a chitinase activity with its optimum pH around 3.0, we undertook molecular cloning of a cDNA encoding this putative gastric chitinase. By use of 2 degenerate oligonucleotide primers derived from the 2 conserved regions of the vertebrate chitinases, a reverse transcription-PCR product was obtained. This product was used as a probe to screen a cDNA library constructed from the toad stomach. The longest positive clone was revealed to contain an open reading frame for a putative chitinase protein of 484 amino acids, which protein exhibited sequence similarity to the known vertebrate chitinases. Our data also revealed this putative gastric chitinase to be distinct from the chitinase that we had previously isolated from the pancreas of the same species. In this putative gastric chitinase, both the N-terminal catalytic domain and the C-terminal chitin-binding domain were perfectly conserved, suggesting this protein to function as chitinase in the toad stomach.
Analysis of spatial and temporal gene expression patterns in blastula and gastrula stage chick embryos.

Studies on the genetic basis of rostral-caudal specification, neural induction, and head development require knowledge of the relevant gene expression patterns. Gaps in our understanding of gene expression have led us to examine the detailed spatiotemporal expression patterns of 19 genes implicated in early development, to learn more about their potential role in specifying and patterning early developmental processes leading to head formation. Here, we report the expression patterns of these markers in blastula- and gastrula-stage chick embryos, using whole-mount in situ hybridisation. Nodal, Fgf8, Bmp7, Chordin, Lim1, Hnf3beta, Otx2, Goosecoid, Cerberus, Hex, Dickkopf1, and Crescent are all already expressed by the time the egg is laid. When the primitive streak has reached its full length, a later group of genes, including Ganf, Six3, Bmp2, Bmp4, Noggin, Follistatin, and Qin (BF1), begins to be expressed. We reassess current models of early rostral patterning based on the analysis of these dynamic spatiotemporal expression patterns.
Comparison of one cycle control of charge and current for bi-directional boost rectifiers

Classical control and one cycle control of current are popular methods used to modulate pulses in active rectifiers for ac-dc power conversion. One cycle control has lower control complexity and can be implemented using linear analog circuits when compared with the classical approach. However, it also suffers from problems such as instability and offsets in current that is severe at light load conditions. A control strategy for bidirectional boost rectifiers based on one cycle control of charge is proposed for that overcomes these limitations. The integral of sensed current, which represents charge, is compared with a non-linear carrier, which is modified for ac-dc power conversion. This generates the gating signals for the switching devices. The modifications required for the control law governing one cycle control of charge is derived in the paper. Detailed simulation studies are carried out to compare one cycle control of current with the proposed method for ac-dc power conversion, which are validated on a laboratory hardware prototype.
Psychological Adjustment of Elderly Caregivers of People with Dementia

Dementia is a disease that affects the elderly, and their caregivers, in many cases, are also elderly. Considering that caring for a person with dementia affects the health of caregivers, the aim of this study is to check the degree of psychological adjustment in a sample of 51 elderly family caregivers of people with dementia (31 women and 20 men), and test the relationship between their psychological adjustment and their physical, psychological and emotional health. The results show the importance of these characteristics in elderly caregivers and this is a further step to adapt psychological interventions to them.
The Trace Ratio Optimization Problem for Dimensionality Reduction

This paper considers the problem of optimizing the ratio $\mathrm{Tr}[V^{T}AV]/\mathrm{Tr}[V^{T}BV]$ over all unitary matrices $V$ with $p$ columns, where $A,B$ are two positive definite matrices. This problem is common in supervised learning techniques. However, because its numerical solution is typically expensive it is often replaced by the simpler optimization problem which consists of optimizing $\mathrm{Tr}[V^{T}AV]$ under the constraint that $V^{T}BV=I$, the identity matrix. The goal of this paper is to examine this trace ratio optimization problem in detail, to consider different algorithms for solving it, and to illustrate the use of these algorithms for dimensionality reduction.
Direct Presentation Regulates the Magnitude of the CD8+ T Cell Response to Cell-Associated Antigen through Prolonged T Cell Proliferation

The magnitude and complexity of Ag-specific CD8+ T cell responses is determined by intrinsic properties of the immune system and extrinsic factors, such as vaccination. We evaluated mechanisms that regulate the CD8+ T cell response to two distinct determinants derived from the same protein Ag, SV40 T Ag (T Ag), following immunization of C57BL/6 mice with T Ag-transformed cells. The results show that direct presentation of T cell determinants by T Ag-transformed cells regulates the magnitude of the CD8+ T cell response in vivo but not the immunodominance hierarchy. The immunodominance hierarchy was reversed in a dose-dependent manner by addition of excess naive T cells targeting the subdominant determinant. However, T cell competition played only a minor role in limiting T cell accumulation under physiological conditions. We found that the magnitude of the T cell response was regulated by the ability of T Ag-transformed cells to directly present the T Ag determinants. The hierarchy of the CD8+ T cell response was maintained when Ag presentation in vivo was restricted to cross-presentation, but the presence of T Ag-transformed cells capable of direct presentation dramatically enhanced T cell accumulation at the peak of the response. This enhancement was due to a prolonged period of T cell proliferation, resulting in a delay in T cell contraction. Our findings reveal that direct presentation by nonprofessional APCs can dramatically enhance accumulation of CD8+ T cells during the primary response, revealing a potential strategy to enhance vaccination approaches.
Customer Satisfaction with Indian Mobile Services

This study investigates the antecedents of customer satisfaction with Indian mobiles services. The American Customer Satisfaction Index (ACSI) model is used as the framework to examine the causal relationships among customer expectations, quality, value, satisfaction and loyalty. The responses were collected using a structured questionnaire from 199 post-paid mobile subscribers in a major city in India. The results from structural equation modeling show that perceived quality is an important predictor to customer satisfaction, which ultimately results in trust, price tolerance and customer loyalty. The findings provide valuable managerial insights for managing customer satisfaction and loyalty.
Epidemiology of myasthenia gravis with anti-muscle specific kinase antibodies in the Netherlands

The epidemiology of myasthenia gravis subtypes and the frequency of antibodies to muscle-specific kinase (MuSK) was studied in patients with generalised myasthenia gravis without anti-acetylcholine receptor antibodies who had an onset of symptoms between 1990 and 2004 in a well-defined region in the Netherlands. The nationwide prevalence and incidence of myasthenia gravis with anti-MuSK antibodies were also studied. MuSK antibodies were found in 22% of patients with generalised myasthenia gravis without anti-acetylcholine receptor antibodies. Nationwide, 35 patients with MuSK myasthenia gravis were identified, yielding a prevalence of 1.9 per million (95% confidence interval (CI) 1.22 to 2.59) and an annual incidence 0.10 per million person-years (95% CI 0.06 to 0.14).
A novel effective metasurface in low-profile microstrip antenna

In this paper, a low-profile (0.5mm) antenna designed for wearable uses with metasurface as the ground is proposed. The new periodic metasurface is analyzed in detail to discuss its influence and performance. The simulation and experimental results show that this kind of metasurface has a significant performance to low-profile antenna, a strong bend tolerance, and a safe SAR to human body.
The Internet Of Things On Security Research

As the basis of Things.Wireless sensor net(WSN) and other traditional networks with different security requirements.Discusses the security threats facing the WSN,and to address these obstacles to security issues.Analysis of WSN security architecture,focusing on the WSN security protocols.For WSN in order to solve security issues to provide some reference.
Performance‐steered design of software architectures for embedded multicore systems

Many software applications demanding a considerable computing power are moving towards the field of embedded systems (and, in particular, hand‐held devices). A possible way to increase the computing power of this kind of platform, so that both cost and power consumption are kept low, is the employment of multiple CPU cores on the same chipset. Consequently, it is essential to design applications that meet performance requirements leveraging the underlying parallel platform. As embedded applications are usually built using different components (whose source code is often not available) from different companies, the designer can mostly only operate at the architectural level. So far, methodologies for designing software architectures have mainly addressed general‐purpose systems, often relying on hardware platforms with a high degree of parallelism. In this paper, we present our experience in architectural design of parallel embedded applications; as a result, we propose a possible methodology for the application design at the architectural level, targeted to embedded systems built upon multicore chipsets with a low degree of parallelism. It makes use of performance predictions, obtained by simulations. Such a methodology can be employed both for retargeting existing sequential applications to parallel processing platforms and for designing complete applications from scratch. We show the application of the proposed methodology to an embedded digital cartographic system. Starting with a software description using UML diagrams, candidate software architectures (utilizing different parallel solutions) are first defined and then evaluated, to end with the selection of the one yielding the highest performance gain. Copyright © 2002 John Wiley & Sons, Ltd.
Logistics and the environment: Is it an established subject?

The issue of environmental implications of logistics systems is one of the future challenges to logisticians. The purpose of this paper is to explore the logistics and supply chain management (SCM) discipline to see how the scientific community handles this challenge. Observations in the primary literature have revealed that there are weak ties between the logistics/SCM discipline and the environmental discipline. Our analysis indicates that the literature seems to be unbalanced: knowledge about assessing “impact of logistics on environment” is missing, and most emphasis is on “impact of environment on logistics”. Knowledge about implementation comes mainly within reverse logistics literature, which has been described by scholars as exploratory and anecdotal. When comparing the subject logistics/supply chain management and environment (log/SC and environ) with other subjects in the logistics literature, less attention has been paid to “log/SC and environ”. Moreover, almost half the articles on “log/SC and environ” are published outside the primary logistics-related journals.
Quasi-Linear Convective System Mesovorticies and Tornadoes

Quasi-linear convective system are a common occurance in the spring and summer months and with them come the risk of them producing mesovorticies. These mesovorticies are small and compact and can cause isolated and concentrated areas of damage from high winds and in some cases can produce weak tornadoes. This paper analyzes how and when QLCSs and mesovorticies develop, how to identify a mesovortex using various tools from radar, and finally a look at how common is it for a QLCS to put spawn a tornado across the United
Some Pyrazole and Pyrazolo[3,4‐d]pyrimidine Derivatives: Synthesis and Anticancer Evaluation

5‐Amino‐1‐p‐tolyl‐1H‐pyrazole‐4‐carbonitrile (1) was used for the preparation of some novel pyrazoles and pyrazolo[3,4‐d]pyrimidines 2–10. Moreover, the cytotoxicity and in vitro anticancer activities of the prepared compounds were also assessed against the MCF‐7 breast cancer, HepG2 liver cancer, and A549 lung carcinoma cell lines, along with investigation of the effect of the synthesized compounds on the expression of urokinase plasminogen activator (uPA). The tested compounds exhibited remarkable cytotoxic activity against MCF‐7 and HepG2 cells. Among the tested compounds, 2 and 9 revealed promising anticancer activity compared to the activity of the commonly used anticancer drug, doxorubicin, by inhibiting the expression of uPA.
Eco marketing in agriculture and barriers to organic food sales

Eco-agriculture is based on the biological approach, in which nature is a unified whole. Its aim is sustainable and ecologically balanced agricultural system producing quality food, protecting and using natural resources and landscapes in a sustainable manner. Market output of eco-agriculture is organic food. Its successful application in the market is distorted by the action of the barriers to their consumption and barriers to quality, price, situational, habit, motivation, information and trust barriers. To overcome these barriers contributes active using of eco marketing tools.
The development of store brands and the store as a brand in supermarkets in the Netherlands

The price war between supermarkets in the Netherlands, which was launched in October 2003 by Albert Heijn, has strongly influenced the position and development of store brands and store formulas. Based on international research, we can conclude that the store brand is used increasingly frequently as an instrument for store formula positioning. This has resulted in a growing relevance of the market share of the store brands. When the distance between store brands and manufacturer brands gets smaller with regard to quality, perceived value and confidence, price ultimately becomes the only clearly distinguishing characteristic. In that situation, retailers have the opportunity to use store brands in the process of ‘branding’ the store formula. If retailers then proceed to combat each other with a strong focus on price promotions for both manufacturer brands and store brands, store loyalty is undermined and store duplication is stimulated. The price war that was initiated by Albert Heijn gave rise to such a situation. This article puts the Dutch developments in an international context.
Illustrating the Methodology in EKNR (2016): Some Simple Examples

This note considers special cases of the model in Eaton, Kortum, Neiman, and Romalis (2016, henceforth EKNR). The objective is to demonstrate how the methodology works in simplified settings. Our web pages contain Matlab programs to implement the procedures described below. The full model of EKNR includes multiple countries, multiple sectors, a complete set of country-specific input-output linkages, and factor shares that vary by country and sector. Producers in each sector produce heterogeneous goods with efficiency levels that differ across countries. Stocks of durables and structures are accumulated subject to adjustment costs. Capital is used in production (producer durables and structures) and by households (consumer durables and housing). In the simpler setting considered here, a durables sector D produces a capital good and a services sector S produces a consumption good. There are no intermediates. Factor shares are identical across sectors. A single capital stock is used only for production. We start with the very simplest case of a single country, treating producers within a sector as producing a homogenous good. Capital accumulation is not subject to adjustment costs. We then turn to a multi-country world, introducing differentiated goods and heterogeneous efficiencies. We also introduce costs of adjustment in capital accumulation, allowing us to ignore corner solutions of zero investment at the country level. In both the closed economy and open economy settings, we use a planner’s problem to characterize the solution to the competitive equilibrium and show how to compute it. In each case, we also show how to calibrate and compute the model in a more convenient way as in EKNR, extending to a dynamic setting the “exact hat algebra” approach used by Dekle, Eaton, and Kortum (2007) and extended in Costinot and Rodŕiguez-Clare (2014).
A case of presumptive monosomy 21 re-diagnosed as unbalanced t(5p;21q) by FISH and review of literature.

By using fluorescence in situ hybridization (FISH), we demonstrate a case of monosomy 21 to result from an unbalanced translocation involving the short arm of chromosome 5 and the long arm of chromosome 21. Our case is compared to 3 similar cases of t(5p;21q) reported recently, which were also originally diagnosed as monosomy 21. The breakpoint on chromosome 5 in these cases occurred in the p13-p15 region, whereas the breakpoint on chromosome 21 was in the q21-q22 region. Comparison of the clinical findings in these patients demonstrated great similarities. Furthermore, a strong correlation between the clinical manifestations of these patients with cridu-chat syndrome patients was also noted. We suggest that cases with unbalanced t(5p;21q) represent a distinct syndrome which can be grouped under a new category of "5p/21q deletion syndrome. "
Cutting Edge: Activation of Murine TLR8 by a Combination of Imidazoquinoline Immune Response Modifiers and PolyT Oligodeoxynucleotides

Synthetic immune response modifiers (IRM) such as imidazoquinolines can selectively activate human TLR7 or TLR8. Although these endosomal TLRs are close relatives, TLR7-deficient mice are unresponsive to TLR8 agonist IRMs. Similarly, natural ssRNA cannot activate murine TLR8, leading to the belief that murine TLR8 is nonfunctional. In this study, we transfected HEK293 cells with murine TLR8 and NF-κB reporter constructs and stimulated them with combinations of IRM and oligodeoxynucleotides (ODNs). When stimulated with TLR7 or TLR8 agonists alone, no NF-κB response was observed. However, a combination of polyT ODN plus the TLR8 agonist activated NF-κB, whereas polyT ODN plus the TLR7 agonist did not activate. Primary mouse cells responded to the IRM/polyT ODN by secreting TNF. Cells from TLR7−/− and TLR9−/− mice responded to the IRM/polyT ODN combination, whereas MyD88−/− cells did not respond. In conclusion, this study demonstrates for the first time that mouse TLR8 is functional.