Miracle-dz/UniFAR-FTUs huggingface dataset:
Interpretation of erythropoietin levels in patients with various degrees of renal insufficiency and anemia.

BACKGROUND Chronic renal failure leads to hyporegenerative anemia due to erythropoietin deficiency. The creatinine clearance and hemoglobin levels, at which anemia treatment with recombinant erythropoietin should be started, are unclear. Interpretation of serum erythropoietin levels in the context of renal insufficiency remains controversial and was addressed in this study. METHODS Three hundred and ninety-five patients were randomly chosen out of over 5000 consecutive patients investigated by coronary angiography at a single center between 1997 and 2001. Laboratory values and clinical information were prospectively collected in a central registry. Serum samples were frozen before angiography and now used to measure serum erythropoietin levels and evaluate the relationship between erythropoietin and hemoglobin levels in the context of various degrees of renal insufficiency. RESULTS The patients with the lowest renal function (creatinine clearance <20 mL/min) had significantly lower hemoglobin levels than the group with normal renal function. However, erythropoietin levels were identical indicating a lower set point for erythropoietin regulation. Above a creatinine clearance of 40 mL/min a significant inverse correlation between erythropoietin and hemoglobin levels was observed and described with the formula erythropoietin [U/L]= 2.5 x (140 - hemoglobin [g/L]) or alternatively Deltaerythropoietin (U/L) =-2.5 xDeltahemoglobin (g/L). Below 40 mL/min no significant correlation was found. CONCLUSION A cut-off level for an altered set point of erythropoietin regulation was determined at 40 mL/min creatinine clearance. Above this cut-off hemoglobin negatively regulates erythropoietin. Below the cut-off erythropoietin levels remain stable. Pathophysiologic concepts for this finding and clinical implications in patients with moderate renal failure are discussed.
A Phytopharmacological Overview on Perilla frutescens L Review

Since the dawn of civilization, human being is dependent on higher plant species for their foods, clothing, shelter and health care needs. The plant species were the main parts of folk medicine practiced by the ancient peoples in different parts of the world. Perilla frutescens (L.) is an annual short-day plant belonging to the family Labiatae which is used by ancient people in different parts of world. The P. frutescens have been used as an important traditional herbal medicine for treating various disease including depression, anxiety, tumor, cough, antioxidant, allergy, intoxication, and some intestinal disorders Perilla seeds contain considerably high levels (approx. 60%) of α-linolenic acid, which can be expected to possess various biological activities. The leaves are said to helpful for asthma, colds and flu’s. The current review is about collection of all the available data on identified chemical constituents as well as the reported pharmacological activities of Perilla frutescens.
Realization of crawling motion by an underactuated robot with changing constraints

Human beings, animals and insects can realize locomotion by changing the supported points of the legs or the contact points of the body. One of the key features of the locomotion is the change of constraint conditions. In this paper we realize crawling motion by an underactuated robot. By changing the location of the fixed point of the robot to the environment, the constraint of the system is changed. A control law based on partial feedback linearization is proposed and stability of the closed-loop system is discussed. We discuss trajectory planning of the robot based on the geometric relation. Experiments have been carried out to demonstrate the effectiveness of the proposed controller.
Accurate load sharing control in autonomous operation of microgrid

The paper investigates the active power and reactive power sharing in autonomous operation of Microgrid with multiple distributed generations. Conventional f-P droop and V-Q droop can not ensure the accuracy of power sharing when line parameters mismatch. A novel scheme for accurate load sharing is proposed, considering the resistor and inductance of transmission line. The scheme presents superior behavior in comparison with conventional method, especially in reactive power sharing. Simulation results prove the good performance for two parallel VSI. Small-signal stability analysis is shown here.
CIAO-WPS - Automatic and Intelligent Orchestration of Geospatial Web Services using Semantic Web (Web 3.0) Technologies

Current geospatial datasets and web services are disparate, obscure and difficult to expose to the world. With the advent of geospatial processes utilizing temporal data and big data, along with datasets continually increasing in size, the problem of under-exposed datasets and web services is amplified. Current text search capabilities do not sufficiently expose web services and datasets for use in on-the-fly geospatial use cases. End users are required to know the exact location of these online resources, their format and what they do. For example, to locate an OGC (Open Geospatial Consortium http://www.opengeospatial.org)-compliant WPS (Web Processing Service) that performs flood modelling, a Google Search for “Flood Modelling WPS” is insufficient to find relevant results. This paper proposes the integration of semantic web concepts and technologies into geospatial datasets and web services, making it possible to link these datasets and services via functionality, the inputs required and the outputs produced. To do so requires the extensive use of metadata to allow for a standardised form of description of their function. There are already ISO (International Organization for Standardization www.iso.org) standards in place (ISO 19115-1:2014) that specify the schema required for describing geographic information and services. The use of ontologies and AI (Artificial Intelligence) then allows for the intelligent determination of which web services and datasets to use, and in what order they are to be used to achieve the desired final output. This research aims to provide a method to automatically and intelligently chain together web services and datasets to assist in a geospatial analyst’s productivity. A simple prototype termed CIAO-WPS (Chet’s Intelligent, Automatically-Orchestrated Web Processing Services) is created as a proof of concept, using the Python programming language. The prototype seeks to reinforce ideas in regards to pathing and cost constraints, as well as explore overlooked designs.
Cheeks : Sculpting and volumising with Restylane ® SubQ

Introduction The cheek is one of the most influential features of the ageing face. Rohrich and Pessa (2008) studied the chronological changes in subcutaneous fat distribution and observed the existence of separate anatomical compartments which appear to lose volume in a specific order (see Figure 1). Volume depletion and re-positioning of the malar fat pad occur early in the ageing process (Rohrich and Pessa 2008, Coleman and Grover 2006). They create a gradual flattening of the malar eminence, both frontally and laterally, and lead to a hollowing out of the mid-facial region and emphasis of the nasolabial furrow (see Figures 5-7). The downturn of the oral commissure is also exacerbated and, in some cases, tissue decent extends as far as the pre-jowl sulcus, accentuating the S-shaped curve of the lower mandibular border. Cheek augmentation restores youthful convexity and helps support the lower facial tissues, giving rise to a mid-
Cocaine induces cell death within the primate fetal cerebral wall

Transferase dUTP nick‐end labelling (TUNEL) analysis was used to compare the occurrence of cell death in the cerebral wall of cocaine‐exposed and drug‐naïve monkey fetuses. The rhesus monkeys providing the drug‐exposed fetuses received 10 mg/kg of cocaine orally (in fruit treats) in the morning and in the evening between pregnancy days 50 and 65. The control pregnant animals received fruit treats only. The fetuses were removed for analysis by Caesarean section 10 h after the last cocaine treatment. The sections of the cerebral wall from the cocaine‐exposed fetuses contained significantly higher numbers of TUNEL‐positive nuclei (counted either per section area or per 1000 unlabeled nuclei) than the matching sections from the drug‐naïve fetuses. This elevation in the number of TUNEL‐positive cells was observed through the entire depth of the fetal cerebral wall including its proliferative and intermediate zones, cortical plate and the marginal zone. The present study demonstrates that consumption of cocaine during pregnancy can result in increased occurrence of cell death in the developing cerebrum.
Stratified Hypermedia Structures for Information Disclosure

In this paper we generalise the two-level approach to hypertext (hypermedia) systems into stratified hypermedia structures. First we describe the overall architecture of such systems, including the fundamentals of the user interface. Thereafter, its various components are discussed. Special emphasis is paid on how the underlying information model is layered. Two layers are featured: the hyperbase and the hyperindex. A characterisation calculus is presented for the characterisation of structured elements. This calculus forms the basis of a logic-based approach in connection with the associated information processor (Disclosure Machine). The logic-based approach is considered as the most general approach to the retrieval process. In addition, this calculus is useful for quality assurance in hypermedia applications. Attention is also paid to spatial coherence for relevance judgements.
Novel nuclear matrix protein HET binds to and influences activity of the HSP27 promoter in human breast cancer cells

Since the small heat shock protein hsp27 enhances both growth and drug resistance in breast cancer cells, and is a bad prognostic factor in certain subsets of breast cancer patients, we have characterized the transcriptional regulation of hsp27, with the long‐term goal of targeting its expression clinically. The majority of the promoter activity resides in the most proximal 200 bp. This region contains an imperfect estrogen response element (ERE) that is separated by a 13‐bp spacer that contains a TATA box. Gel‐shift analysis revealed the binding of a protein (termed HET for Hsp27‐ERE‐TATA‐binding protein) to this region that was neither the estrogen receptor nor TATA‐binding protein. We cloned a complete cDNA (2.9 kb) for HET from an MCF‐7 cDNA library. To confirm the identity of the HET clone, we expressed a partial HET clone as a glutathione S‐transferase fusion protein, and showed binding to the hsp27 promoter fragment in gel‐retardation assays. The HET clone is almost identical to a recently published scaffold attachment factor (SAF‐B) cloned from a HeLa cell cDNA library. Scaffold attachment factors are a subset of nuclear matrix proteins (NMP) that interact with matrix attachment regions. Analyzing how HET could act as a regulator of hsp27 transcription and as a SAF/NMP, we studied its subnuclear localization and its effect on hsp27 transcription in human breast cancer cells. We were able to show that HET is localized in the nuclear matrix in various breast cancer cell lines. Furthermore, in transient transfection assays using hsp27 promoter‐luciferase reporter constructs, HET overexpression resulted in a dose‐dependent decrease of hsp27 promoter activity in several cell lines. J. Cell. Biochem. 67:275–286, 1997. © 1997 Wiley‐Liss, Inc.
Intestinal Mucosa in Nephropathic Cystinosis

The major manifestations of nephropathic cystinosis are renal tubular acidosis, vitamin D-resistant rickets, and dwarfism. Cystine crystals are deposited in a variety of cells, mainly phagocytic, including macro-phages of the intestinal lamina propria. Previously, ultrastructural changes were suggested to occur in the absorptive epithelium as well, possibly as a result of local cystine toxicity. We report here on the light- and electron-microscopic findings in the jejunal mucosa of two patients, aged 4 and 9 years with nephropathic cystinosis. Cystine crystals were easily identified in semithin sections of plastic-embedded specimens as brick- and hexagon-shaped spaces in macrophages. Electron microscopy showed that all crystals were in single-membrane-limited bodies (lysosomes), within phagocytic cells, and exclusively located in the lamina propria. In contrast to previous findings, the absorptive epithelium showed no abnormalities. We conclude that the growth failure in cystinosis is not a consequence of morphological toxic alterations in the intestinal epithelium, but is related to the known metabolic abnormalities of this condition. The use of rectal suction biopsy as a means of diagnosing cystinosis is also suggested as an alternative to other diagnostic methods.
Social problem-solving abilities, relationship satisfaction and depression among family caregivers of stroke survivors

Primary objective: To examine the prospective relation of caregiver problem-solving abilities and relationship satisfaction to caregiver depression 1 month following care recipient discharge from an inpatient stroke rehabilitation facility. Research design: Correlational, prospective design. Methods and procedures: Participants included 39 women (average age = 51.47, SD = 20.59) and four men (average age = 42.50, SD = 5.57) assuming caregiver roles for persons discharged from stroke rehabilitation. Main outcome measure: The Beck Depression Inventory was the outcome measure at discharge and 1 month later. Results: Caregivers experienced a significant decrease in depression scores between the discharge and 1-month assessments. Lower relationship satisfaction and dysfunctional problem-solving abilities were independently and significantly predictive of depression scores at discharge. Dysfunctional problem-solving abilities were indirectly predictive of depression 1 month later. Conclusions: Dysfunctional problem-solving abilities and low relationship satisfaction are associated with caregiver depression, but dysfunctional problem-solving abilities maintain an indirect association with depression over 1 month. Implications of these findings for developing problem-solving training programmes for caregivers post-discharge are discussed.
STI-induced damage and hot-carrier reliability in the narrow width short channel NMOSFET fabricated using global strained-Si technology

The width dependence of threshold voltage (V/sub t/) in the strained-Si NMOSFET relative to that of the control bulk Si device is examined. The contrasting behavior of V/sub t/, for decreasing channel width (W/sub drawn/) at a given channel length (L/sub drawn/), could be ascribed to the increased concentration of the channel dopant at the regions near the STI (shallow trench isolation)/gate edge of the strained device. Dopant enhancement is attributed to the abundance of interstitial defect sites located in both the strained-Si and the SiGe layer, due to the lattice strain arising from the STI process. Hot-carrier degradation is found to be marginally higher in the narrow-width strained device.
The Neurophysiology of Tone : Four Decades of Research

Tone processing has been used as a vehicle for investigating numerous questions concerning the neurophysiology of basic auditory perception, language, and music. Behavioral, dichotic-listening, lesion, and functional and anatomical neuroimaging studies have shed light on various debates of the neural organization of perceptual information. From our early fascination of hemispheric specialization to more recently the neurogenetics of language, the study of tone has always provided key evidence for our most current understanding of the brain. Here, we provide a historical overview of the key issues and present findings from our laboratory from the past decade that contribute to these debates.
Fenotipagem forense pelo DNA através de SNPs

A fenotipagem forense pelo DNA se apresenta como uma abordagem promissora para suprir lacunas na busca de pessoas desconhecidas, em investigacoes criminais, e na identificacao de vitimas de catastrofes e de pessoas desaparecidas. Essa metodologia permite a previsao individual de caracteristicas externamente visiveis (CEVs) a partir de analises com SNPs informativos de fenotipos. Entre esses SNPs, os mais bem descritos sao aqueles relacionados com as caracteristicas de pigmentacao, como cor dos olhos, pele e cabelo. Estudos vem demonstrando o elevado poder de predicao dessas CEVs, apresentando resultados satisfatorios na predicao da cor de iris castanha e azul e cabelo ruivo, enquanto para as demais ainda sao necessarias mais pesquisas para predizer com precisao esses fenotipos. Embora seja muito promissora, a aplicacao pratica da fenotipagem forense pelo DNA levanta diversas questoes de ordem etica e legal. No Brasil, avancos ainda precisam acontecer, uma vez que a populacao brasileira e heterogenea e grande parte dos marcadores descritos e relacionada as populacoes europeias. Neste sentido, o Brasil ja conta com a Rede Integrada de Bancos de Perfis Geneticos (RIBPG), a qual visa compartilhar e comparar os perfis geneticos entre os bancos do pais. Em um futuro proximo essa metodologia estara apta a integrar as rotinas forenses, com grande aplicabilidade e confiabilidade.
Text Mining Electronic Health Records to Identify Hospital Adverse Events

Manual reviews of health records to identify possible adverse events are time consuming. We are developing a method based on natural language processing to quickly search electronic health records for common triggers and adverse events. Our results agree fairly well with those obtained using manual reviews, and we therefore believe that it is possible to develop automatic tools for monitoring aspects of patient safety.
Cellularization in Drosophila melanogaster is disrupted by the inhibition of rho activity and the activation of Cdc42 function.

Regulation of cytoskeletal dynamics is essential for cell shape change and morphogenesis. Drosophila melanogaster embryos offer a well-defined system for observing alterations in the cytoskeleton during the process of cellularization, a specialized form of cytokinesis. During cellularization, the actomyosin cytoskeleton forms a hexagonal array and drives invagination of the plasma membrane between the nuclei located at the cortex of the syncytial blastoderm. Rho, Rac, and Cdc42 proteins are members of the Rho subfamily of Ras-related G proteins that are involved in the formation and maintenance of the actin cytoskeleton throughout phylogeny and in D. melanogaster. To investigate how Rho subfamily activity affects the cytoskeleton during cellularization stages, embryos were microinjected with C3 exoenzyme from Clostridium botulinum or with wild-type, constitutively active, or dominant negative versions of Rho, Rac, and Cdc42 proteins. C3 exoenzyme ADP-ribosylates and inactivates Rho with high specificity, whereas constitutively active dominant mutations remain in the activated GTP-bound state to activate downstream effectors. Dominant negative mutations likely inhibit endogenous small G protein activity by sequestering exchange factors. Of the 10 agents microinjected, C3 exoenzyme, constitutively active Cdc42, and dominant negative Rho have a specific and indistinguishable effect: the actomyosin cytoskeleton is disrupted, cellularization halts, and embryogenesis arrests. Time-lapse video records of DIC imaged embryos show that nuclei in injected regions move away from the cortex of the embryo, thereby phenocopying injections of cytochalasin or antimyosin. Rhodamine phalloidin staining reveals that the actin-based hexagonal array normally seen during cellularization is disrupted in a dose-dependent fashion. Additionally, DNA stain reveals that nuclei in the microinjected embryos aggregate in regions that correspond to actin disruption. These embryos halt in cellularization and do not proceed to gastrulation. We conclude that Rho activity and Cdc42 regulation are required for cytoskeletal function in actomyosin-driven furrow canal formation and nuclear positioning.
Development of ventricular fibrillation after implantation of a biventricular implantable cardioverter defibrillator: what is the mechanism?

Syncopal spells in heart failure patient with cardiovascular implantable electronic devices (CIED) require multiple assessments. T‐wave oversensing is a well‐described phenomenon that remains significant in modern implantable cardioverter defibrillators (ICD) systems. It can lead to inappropriate therapies and loss of biventricular pacing in those with cardiac resynchronization devices. Strategies to overcome this problem are important.
Influenza A/H1N1 (2009) Infection as a Cause of Unexpected Out‐of‐Hospital Death in the Young*

Abstract: In March 2009, a new strain of influenza A/H1N1 virus was identified in Mexico, responsible for a pandemic. Worldwide, more than 13,500 patients died, most often from acute respiratory distress syndrome. Because sudden death cases were rare, involving mostly young apparently healthy persons, influenza A/H1N1 (2009)‐related deaths may be misdiagnosed, which can raise medico‐legal issues. Case history: we report on an unexpected out‐of‐hospital death involving a young male with no past medical history and no vaccination. Fever was his only symptom. Laboratory tests: histology showed patchy necrotic foci with mononuclear inflammation in the lungs. The heart was histologically normal, but virological analyses using molecular biology on frozen myocardial samples showed high virus load. In conclusion, this case report shows that influenza A/H1N1 (2009) virus can be a cause of sudden cardiac death in the young and demonstrates the importance of quantitative virological analyses for the diagnosis of myocarditis.