Miracle-dz/UniFAR-FTUs huggingface dataset:
Ultrasmall Renally-clearable Silica Nanoparticles Target Prostate Cancer.

Although important advances have been achieved in the development of radiolabeled prostate-specific membrane antigen (PSMA)-targeting ligand constructs for both diagnosis and therapy of prostate cancer (PCa) over the past decade, challenges related to off-target effects and limited treatment responses persist. In this study, which builds upon the successful clinical translation of a series of ultrasmall, dye-encapsulating core-shell silica nanoparticles, or Cornell Prime Dots (C' dots), for cancer management, we sought to address these limitations by designing a dual-modality, PSMA-targeting platform that evades undesirable accumulations in the salivary glands, kidneys, and reticuloendothelial system, while exhibiting bulk renal clearance. This versatile PCa-targeted particle imaging probe offers significant clinical potential to improve future theranostic applications in a variety of patient care settings.
Analysing fragmentation in vulnerable biodiversity hotspots in Tanzania from 1975 to 2012 using remote sensing and fragstats

Habitat fragmentation is a threat to conservation of biodiversity hotspots in the Morogoro region, Tanzania. However, on-going research on fragmentation has not kept pace with temporal lapses and how individual species respond to habitat transformation and heterogeneity. This study sought to model spatial and temporal fragmentation patterns. Cloud free multi-temporal Landsat imagery with similar spectral resolution were acquired in the same season in 1975, 1995 and 2012. The images were used to characterize the biophysical landscape characteristics and a range of metrics used to quantify the magnitude of fragmentation. Patches and classes in the landscape were assessed using Fragstats, a spatial statistics program useful in computing landscape metrics. Results show that patch number was higher in dense forest and woodland than in less dense forest and grassland in 1975, 1995 and 2012 while the interspersion Juxtaposition Index (IJI) ranged between 0 (for clumped patches) and 100 (for grassland). In 1975 and 1995, the grassland habitat had the highest IJI while in 2012 less dense forest had the highest IJI. The GamesHowell test showed a significant fragmentation trend in less dense forests class (p≤0.05). Generally, the study indicates a high fragmentation pattern in the vulnerable tropical eastern arc mountain region of East Africa. This finding demonstrates the value of remotely sensed data in understanding the impact of anthropogenic processes on natural landscape transformation. Furthermore, the study provides a basis for informed conservation policy design and implementation in the region. Nature Conservation 16: 19–37 (2016) doi: 10.3897/natureconservation.16. 9312 http://natureconservation.pensoft. net Copyright M.M. Ojoyi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. RESEARCH ARTICLE Launched to accelerate biodiversity conservation A peer-reviewed open-access journal
An improved Gaussian mixture PHD SLAM algorithm

For two problems in Gaussian mixture probability hypothesis density SLAM(GMPHD-SLAM) algorithm of low estimation accuracy and high computational cost, the GMPHD-SLAM algorithm based on unscented transform, called unscented-GMPHD-SLAM, is proposed. The main contribution lies that: the unscented Kalman filter is used in the calculation of particle’s weight and PHD update process, which improves the performance of the algorithm; the updated Gaussian components are classified based on the sensor’s field of view(FoV) , which reduces the computational cost. The proposed algorithm is compared with the traditional PHD-SLAM algorithm. The results show that the proposed algorithm is effective in accuracy improvement and reduction of computational cost.
Surface Premelting Coupled with Bulk Melting and Solid-solid Transitions in Attractive Colloidal Crystals

Crystal surfaces typically premelt into a thin liquid layer slightly below the melting point. Such surface premelting are prevalent in all classes of solids and plays important roles in metallurgy, geology, and meteorology such as glacier movement, frost heave, snowflake growth, and skating [1– 3]. Premelting has been studied using X-ray diffraction [4], and differential scanning calorimetry [5] which lack single-particle resolution, hence, the underlying premelting mechanisms are not clearly understood. Colloids are outstanding model systems for studying phase transitions [6] because the thermal motions of individual micron-sized particles can be directly tracked using optical microscopy [7]. Here, we employed colloidal spheres with tunable attractions to form equilibrium crystal-vapor interfaces and studied their surface premelting behaviours with singleparticle dynamics. We found that monolayer crystals exhibited incomplete blocked premelting with a constant surface-liquid thickness, whereas twoand three-layer crystals exhibited conventional complete melting with divergent surface-liquid thicknesses. The microstructures of the surface liquids partly deviated from the conventional assumptions in premelting theories. We discovered a novel mechanism that the incomplete premelting is triggered by a bulk isostructural solid-solid transition and interrupted by a mechanical-instability-induced homogeneous bulk melting. Twodimensional (2D) melting under the presence of free surfaces (i.e. solid-vapor interface) has yet to be observed at the single-particle level. In contrast to the conventionally assumed surface melting for 2D and three-dimensional (3D) crystals [5, 8], we observed that the 2D crystals melted from within. Such bulk melting was accompanied with the formation of grain boundaries, demonstrating the grain-boundary-mediated 2D melting scenario [9] in attractive crystals. These novel interplays among surface premelting, bulk melting, and solid-solid transitions cast new light to all of them and present challenges on surface premelting and 2D melting theories. 2 This is the Pre-Published Version
Design and analysis of the 4-anilino-quin(az)oline kinase inhibition profiles of GAK/SLK/STK10 using quantitative structure activity relationships

The 4-anilino-quinoline and 4-anilino-quinazoline ring systems have been the focus of significant efforts in prior kinase drug discovery programs, which have led to approved medicines. Broad kinome profiles of these compounds have now been assessed with the advent of advanced screening technologies. These ring systems while, originally designed for specific targets including epidermal growth factor receptor (EGFR), actually display a number of potent collateral kinase targets, some of which have been associated with negative clinical outcomes. We have designed and synthesized a series of 4-anilino-quin(az)olines in order to better understand the structure activity relationships of three main collateral kinase targets of quin(az)oline-based kinase inhibitors: cyclin G associated kinase (GAK), STE20-like serine/threonine-protein kinase (SLK) and Serine/threonine-protein kinase 10 (STK10) through a series of quantitative structure activity relationship (QSAR) analysis and water mapping of the kinase ATP binding sites.
Exploring and Curating Data Collections with CURARE: demonstration

This paper demonstrates CURARE, an environment for curating raw data collections and assisting data scientists to explore them. CURARE implements a data curation model used to store structural and quantitative metadata such as the number of columns, de name of columns and the statistics of the values of every column. It provides associated functions for exploring these metadata. The demonstration proposed in this paper is devoted to evaluate and compare the effort invested by a data scientist when exploring data collections with and without CURARE assistance.
Modular, Reconfigurable Block Cell Antenna Concept for Millimeter-wave 5G

A reconfigurable block cell antenna (BCA) concept is proposed for millimeter-wave (mmWave) 5G applications. The 4×4 BCA is exemplified using a low temperature co-fired ceramic (LTCC) process. All ports of the proposed BCA achieve a reflection coefficient below - 10 dB in 28.5 GHz. The proposed BCA features a maximum gain of 7.6 dBi and 15 different modes that can support multiple polarizations and a half of the spherical beamsteering angle.
On Shifted Weibull-Pareto Distribution

The Lomax distribution, known as Pareto (type II) distribution, is a heavy tail probability distribution used extensively in business, economics and in actuarial modeling. The Weibull-Pareto distribution defined by Alzaatreh et al. (2013a) has shown high bias and standard error for the ML estimates when the parameter $c>>1$. In this paper we use the Lomax distribution to construct the Weibull-Lomax distribution. It is observed that the Weibull-Lomax distribution performs significantly better in terms of the ML estimations. Some structural properties of the Weibull-Lomax distribution are discussed.
An Effective Minimal Probing Approach With Micro-Cluster for Distance-Based Outlier Detection in Data Streams

Outlier detection in data streams is considered a significant task in data mining that targets the discovery of elements in an unprecedented data arrival rate. The fast arrival of data demands fast computation within the shortest period, and with minimal memory usage. Detecting distance-based outliers in such a scenario are more complicated. Existing techniques such as the two best-known methods - Micro-Cluster Outlier Detection (MCOD) and Thresh_LEAP have presented some solutions to these challenges. However, the combination of the strength of both techniques can be a lot more improvement to the individual methods proposed. Therefore, in this paper, we propose a method called Micro-Cluster with Minimal Probing (MCMP), which is a hybrid approach of the combination of the strength of MCOD and Thresh_LEAP. We offer a new distance-based outlier detection technique to minimize the computational cost in detecting distance-based outliers effectively. The proposed MCMP technique is comprised of two approaches. Firstly, we adopt micro-clusters to mitigate the range query search. Then, to deal with the objects outside the micro-clusters, we propose the concept of differentiating between strong and trivial inliers. The proposed method improves the computational speed and memory consumption, while simultaneously maintaining the outlier detection accuracy. Our experiments are conducted on both real-world and synthetic data sets. We varied the window size <inline-formula> <tex-math notation="LaTeX">$(w)$ </tex-math></inline-formula>, neighbor count threshold <inline-formula> <tex-math notation="LaTeX">$(k)$ </tex-math></inline-formula> and distance threshold <inline-formula> <tex-math notation="LaTeX">$(R)$ </tex-math></inline-formula>, and observed that our method outperforms the state-of-the-art methods in both CPU time and memory consumption in the majority of the datasets.
Entropy in general physical theories

Information plays an important role in our understanding of the physical world. Hence we propose an entropic measure of information for any physical theory that admits systems, states and measurements. In the quantum and classical worlds, our measure reduces to the von Neumann and Shannon entropies, respectively. It can even be used in a quantum or classical setting where we are only allowed to perform a limited set of operations. In a world that admits superstrong correlations in the form of non-local boxes, our measure can be used to analyze protocols such as superstrong random access encodings and the violation of ‘information causality’. However, we also show that in such a world no entropic measure can exhibit all the properties we commonly accept in a quantum setting. For example, there exists no ‘reasonable’ measure of conditional entropy that is subadditive. Finally, we prove a coding theorem for some theories that is analogous to the quantum and classical settings, providing us with an appealing operational interpretation. 3 Authors to whom any correspondence should be addressed. New Journal of Physics 12 (2010) 033023 1367-2630/10/033023+34$30.00 © IOP Publishing Ltd and Deutsche Physikalische Gesellschaft
Perception of attachment security in families with children affected by neurological illness

This study analyzes inter-family relationships of families with children with neurological problems using Bowlby's attachment theory as model of reference. The research was conducted in two hospitals in Serbia specialized in neurological diseases: cerebral palsy and epilepsy. It is hypothesized that neurological problems could be associated to a discrepancy of inter-family attachment perceptions. Two groups were selected, a clinical one composed of 25 nuclear families: mother, father and child with a certified diagnosis of either cerebral palsy or epilepsy; and a control group of 25 nuclear families: mother, father and child with no pathology. Kerns, Klepace and Cole’s Security Scale (1996) was used for the investigation, with the addition of two modified version for administration to the parents. Data analysis demonstrated that the clinical group is substantively higher (p=.076) with respect to the discrepancy of attachment perceived by the children and the attribution of meaning that parents give to their child's attachment perception towards them. Further analyses carried out on parent-child relationships demonstrated a significant difference (p =.017) between the clinical and control groups, with respect to the perception of father-child attachment. We conclude that in the clinical group, there is a discrepancy of attachment perceptions that particularly affect the father-child relationship. It appears that hospitalization and the consequent separation of the nuclear families may influence the formation of secure attachment relationships, in particular between father and child.
5-GHz Orbital Angular Momentum Array Antenna Design

In this paper, a microstrip array antenna with orbital angular momentum is proposed. Twelve identical printed dipole antennas with microstrip balun feeder are arranged in a dodecahedron cylindrical substrate. By changing the value of the phase difference between successive elements, five kinds of electromagnetic waves of different modes of orbital angular momentum are generated. The simulation results show that the expected results have been achieved with the modalities of OAM 0, 1, 2, 3, 4. Consequently, the proposed orbital angular momentum antenna has a promising prospect.
Dietary patterns and oral and pharyngeal cancer using latent class analysis

The methods traditionally used to identify a posteriori dietary patterns are principal components, factor and cluster analysis. The aim of our study is to assess the relationship between dietary patterns derived with latent class analysis (LCA) and oral/pharyngeal cancer risk (OPC), highlighting the strengths of this method compared to traditional ones. We analyzed data from an Italian multicentric case–control study on OPC including 946 cases and 2,492 hospital controls. Dietary patterns were derived using LCA on 25 food groups. A multiple logistic regression model was used to derive odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for OPC according to the dietary patterns identified. We identified four dietary patterns. The first one was characterized by a high intake of leafy and fruiting vegetable and fruits (Prudent pattern), the second one showed a high intake of red meat and low intake of selected fruits and vegetables (Western pattern). The last two patterns showed a combination‐type of diet. We labeled “Lower consumers‐combination pattern” the cluster that showed a low intake of the majority of foods, and “Higher consumers‐combination pattern” the one characterized by a high intake of various foods. Compared to the “Prudent pattern”, the “Western” and the “Lower consumers‐combination” ones were positively related to the risk of OPC (OR = 2.56, 95% CI: 1.90–3.45 and OR = 2.23, 95% CI: 1.64–3.02). No difference in risk emerged for the “Higher consumers‐combination pattern” (OR = 1.28, 95% CI: 0.92–1.77).
Thyroid Hormone Deiodinases and Receptors Are Expressed in Human Endothelial Cells

A B S T R A C T The endothelial system acts as a large endocrine organ in the human body, however, little is still known about the regulative role of THs on endothelial cells. The present study aims to investigate the expression of the TH deiodinases (D1, D2, D3) and TH receptors (TR1, TR2 and TR1) in an endothelial microvascular cultured cell model (HMEC-1), after stimulation with triiodothyronine (T3, 10-100nM), thyroxine (T4, 10-100nM), and reverse T3 (rT3, 110nM). The main result of the study is that the TH deiodinases and receptors are expressed in endothelial HMEC-1 cells. These findings might be of significant clinical relevance, given the important regulatory role of the endothelium as first barrier to the bloodstream.
A Compact Efficient D-Band Micromachined On-Chip Differential Patch Antenna for Radar Applications*

This paper presents a compact differential D-band on-chip patch antenna with high efficiency based on a localized backside etching (LBE) technique on a 130-nm SiGe BiCMOS technology for radar applications. The on-chip patch antenna is driven differentially to allow direct integration with circuits into single chip and offers a compact realization with high gain and directivity. The geometry of the on-chip antenna and the LBE air trenches are optimized to meet process reliability specifications and radiation performance simultaneously. A prototype antenna is integrated with radar transmitter and fabricated to validate the design where the radiation pattern is measured. The measured peak gain is 7 dBi at 160 GHz with 60 % simulated efficiency. The measured 1-dB gain bandwidth is 10 GHz.
A ug 2 00 7 1 Derivative of BICM Mutual Information

In this letter we determine the derivative of the mutual info rmation corresponding to bit-interleaved coded modulation systems. The derivative follows as a linea r combination of minimum-mean-squared error functions of coded modulation sets. The result finds ap plications to the analysis of communications systems in the wideband regime and to the design of power allo cation over parallel channels.
Design of battery fast charging method combined with improved interleaved topology

In this study, a fast-charging strategy based on improved interleaved buck converter is proposed. Compared with traditional interleaved buck converter, the improved interleaved buck converter can guarantee small switching losses and high efficiency. Meanwhile, a fast-charging strategy is developed in this study. Using a constant current method, which can achieve the effect of fast charging. Finally, the simulation is carried out by SIMPLIS.
The suprasegmental aspects in th Rorschach inkblot test

The present study is a first step in examining the prosodic aspects of the verbal responses to the Rorschach inkblot test. The results suggest a possible relation between the prosodic features in the responses and the psychologicalemotional states of two subjects. For both subjects, the mean F0 of the first sentences for three cards (II,V,X) was significantly higher than their normal values. Moreover, in the subject who was confident in giving her responses, the mean duration of the positive emotion words, was significantly higher than those for the negative emotion words. We also observed a prominent pitch range for the card, which she chose as her favourite one. The results of these primary experiments support an interest for a new method of analysis of the Rorschach discourse based on phonetic knowledge and paralinguistic information conveyed by the speech signal.
Se-acquisition and reactive oxygen species role in growth, photosynthesis, photosynthetic pigments, and biochemical changes in essential oil(s) monoterpene of Geranium (Pelargonium graveolens L.Her.' ex. Ait.).

Se is an essential element required for various metabolic pathways and act as an antioxidant in the various redox-reactions of primary and secondary plant production of - biomolecules. Geranium is an important essential monoterpene oil(s) bearing plant. Culturing the plant at different doses of Se from 0-1.0 μg Se ml -1 revealed that Se plays an important role as an in antioxidant promoter, apart from its micronutrient essentiality. 0.25 μg Se ml -1 is the critical concentrations for maximum content of (0.21%) total essential monoterpene oil(s). At concentration below and above 0.25 μg Se ml -1 , the CO 2 assimilation rate, photosynthetic pigments content and ultimately the accumulation of essential monoterpene oil(s) are affected. The maximum peroxidase and SOD activities were obtained at 0.25 μg Se ml -1 , with the production of biomolecule geraniol. Results revealed an oxido- reducable reaction of Se in the formation of monoterpene essential oil(s) and possibly for the major constituents Geraniol.
Update Therapie der ANCA-assoziierten Vaskulitiden Update on the Treatment of ANCA-associated Vasculitis

Dieser Artikel gibt eine Übersicht über die aktuellen deutschen und europäischen Therapieempfehlungen zu den ANCA-assoziierten Vaskulitiden (AAV) sowie ein Update zu seither publizierten wichtigen Therapiestudien. Nach den deutschen und europäischen Empfehlungen erfolgt die Remissionsinduktion bei GPA/MPA mit organbedrohender Erkrankung mit Glucocorticoiden und Cycloposphamid oder Rituximab, bei nicht organbedrohender Erkrankung mit Glucocorticoiden und Methotrexat (MTX) oder Mycophenolat-Mofetil (MMF). Die kürzlich publizierte MYCYC-Studie unterstützt die Empfehlungen; sie zeigte eine Nicht-Unterlegenheit gegenüber i. v. Cyclosphamid bei GPA/MPA-Patienten mit nicht-organbedrohender und organbedrohender Erkrankung auf. Die remissionserhaltende Therapie soll mit niedrig-dosierten Glucocorticoiden sowie Azathioprin, MTX und Rituximab durchgeführt werden. Rituximab wurde Ende 2018 auf der Basis der MAINRITSAN-Studie als remissionserhaltende Therapie zugelassen und ist damit nun die formal einzige zur Remissionserhaltung zugelassene Therapie. Mehrere Studien zur untersuchten zudem die kurze Anwendung von Glucocorticoiden (z. B. durch additive Therapie mit Avacopan) in der Remissionsinduktion und das komplette Ausschleichen von Glucocorticoiden in der Remissionserhaltung. Die ersten Ergebnisse hierzu sind vielversprechend; Langzeitdaten stehen allerdings aus. Für die sehr viel seltenere EGPA liegen insgesamt deutlich weniger Studiendaten vor. Die Therapie wird jedoch im Wesentlichen nach den gleichen Prinzipien wie bei den anderen AAV durchgeführt. Neuerdings steht, in Deutschland für diese Indikation aber noch nicht zugelassen, eine Biologikatherapie mit dem Anti-IL-5-Antikörper Mepolizumab zur Verfügung.