Miracle-dz/UniFAR-FTUs huggingface dataset:
The association between job skill discretion, decision authority and burnout

This paper reports on the relationship between dimensions of control (skill discretion and decision authority) and burnout (emotional exhaustion, depersonalization, and reduced personal accomplishment) among 164 human service workers. It examines the differential influence of job demands, control (skill discretion and decision authority) and social support (supervisor, co-workers, others) on each burnout dimension. Then it examines the moderating effects of higher skill discretion, higher decision authority, and higher social support on burnout. Low skill discretion was found to be associated with high emotional exhaustion and depersonalization and low personal accomplishment. The effects of decision authority were not statistically significant. High job demands were associated with high emotional exhaustion only. Social support (supervisor, co-worker, and others) was not associated with burnout when demographic variables and job characteristics were controlled for. Neither dimension of control moderated the impact of high job demands on burnout. Social support did not moderate the impact of high demands, low skill discretion, or low decision authority on any burnout dimension. The full model explained 44% of the variance in emotional exhaustion, 25% in depersonalization, and 42% in personal accomplishment. Despite its limitations, the study suggests that the Job Demand-Control model may provide a useful theoretical foundation for the study of burnout, but that the control dimensions need to be evaluated independently since they appear to be differentially related to the burnout dimensions.
Impact Komitmen Organisasi dimediasi Kompetensi SDMTerhadap Kinerja Pegawai Rumah Sakit Swasta di Metro

Tujuan penilitian ini adalah untuk mengetahui pengaruh komitmen organisasi langsung pada kinerja pegawai dan hubungan tak langsung yang dimediasi oleh kompetensi sumber daya manusia. Metode yang digunakan dalam penelitian ini adalah metode secara variatif dengan pengumpulan data primer melalui instrumen penelitian berupa kuesioner yang didistribusikan kepada pegawai kesemua level jabatan fungsional secara random sebanyak 200 responden dan indepth interview di empat rumah sakit swasta kota Metro dan analisis data dilakukan dengan model analisis Structural Equation Modeling (SEM) dengan Smart PLS (Partial Least Square) . Hasil penelitian membuktikan bahwa komitmen organisasi yang direfleksikan oleh tiga komponen yaitu affective commitment and continuance commitment tidak dapat memberikan impact langsung pada kinerja pegawai, tetapi normative commitment dapat memberikan pengaruh positif dan signifikan pada kinerja pegawai, selanjutnya komitmen organisasi dapat memberikan pengaruh positif tidak langsung pada kinerja pegawai melalui proses mediating oleh kompetensi sumber daya manusia serta tingkat komitmen organisasi rata-rata ke empat obyek tersebut tergolong masih rendah. Kata kunci : Komitmen Organisasi, Kompetensi Sumber daya manusia, Kinerja Pegawai. ABSTRACT The purpose of this research is to determine the effect of direct organizational commitment on employee performance and indirect relationships mediated by human resource competencies. The method used in this research is the method are varied with primary data collection through research instrument was a questionnaire distributed to employees of all these levels of functional positions at random as many as 200 respondents and in-depth interviews in four private hospitals in Metro City - Lampung and data analysis performed by the analysis model Structural equation Modeling (SEM) with Smart PLS (Partial Least Square). Research shows that organizational commitment that is reflected by the three components, namely affective commitment and continuance commitment can not provide impact directly on the performance of employees, but normative commitment provide positive and significant impact on the performance of employees, then the organization's commitment providing a positive influence indirectly on performance Employees through the mediating process by the competence of human resources and the level of organizational commitment on average to four objects is still low. Keywords: Competence of human resources, Employee performance. Organizational Commitment
Contribution à l'étude du comportement biomécanique de l'environnement d'un implant dentaire

Plusieurs questions se posent encore, d un point de vue scientifique, sur la nature du comportement immediat et l evolution de l interface os-implant lorsqu'un implant est mis en charge sous une prothese dentaire fixee ou amovible. Les objectifs de notre travail etaient donc d etudier la possibiliteid une mise en charge immediate des implants dentaires, le remodelage osseux peri-implantaire permettant d assurer l osteointegration ainsi que l influence des parametres prothetiques d une prothese amovible complete supra-implantaire (PACSI) mandibulaire sur l implant et son environnement. Deux modeles numeriques ont ete concus. Le premier modele concernait le maxillaire avec l utilisation d un pilier implantaire angule place sur un implant au niveau d une incisive laterale. Il nous a permis d etudier le remodelage osseux autour d un implant sur une periode d osteointegration donnee de 26 mois. Un concept de chargement de securite, correspondant a la preservation de l integrite osseuse, a ete introduit afin de quantifier l effort maximal pouvant etre applique a l implant entre sa premiere mise en charge et son etat osteointegre. Un modele mandibulaire, avec la mise en place des attachements boules sur deux implants dans la region symphysaire et une PACSI, nous a permis de montrer qu'une grande part de l effort de mastication transitait par la muqueuse. Les calculs ont egalement montre que la position des implants au niveau des canines repond au mieux aux objectifs recherches en PACSI, c'est-a-dire une meilleure prise en charge de l effort de mastication par les surfaces d appuis osteo-muqueuses et des contraintes transmises a l os peri-implantaire moins importantes.
Tandemly duplicated upstream control sequences mediate copper-induced transcription of the Saccharomyces cerevisiae copper-metallothionein gene

Transcription of the Saccharomyces cerevisiae copper-metallothionein gene, CUP1, inducible by copper. By analyzing deletion and fusion mutants in the CUP1 5'-flanking region, we identified two closely related, tandemly arranged copper regulatory elements. A synthetic version of one of these elements conferred efficient copper induction on a heterologous promoter when present in two tandem copies.
Cholesterol-dependent Generation of a Seeding Amyloid β-Protein in Cell Culture*

Deposition of aggregated amyloid β-protein (Aβ), a proteolytic cleavage product of the amyloid precursor protein (1), is a critical step in the development of Alzheimer’s disease (2). However, we are far from understanding the molecular mechanisms underlying the initiation of Aβ polymerization in vivo. Here, we report that a seeding Aβ, which catalyzes the fibrillogenesis of soluble Aβ, is generated from the apically missorted amyloid precursor protein in cultured epithelial cells. Furthermore, the generation of this Aβ depends exclusively on the presence of cholesterol in the cells. Taken together with mass spectrometric analysis of this novel Aβ and our recent study (3), it is suggested that a conformationally altered form of Aβ, which acts as a “seed” for amyloid fibril formation, is generated in intracellular cholesterol-rich microdomains.
Uso de grafos conceptuales para la visualización de documentos biomédicos y su utilización para la generación de resúmenes

Con la reciente expansion de Internet y la gran cantidad de informacion a la que podemos acceder, es importante encontrar aquella que sea de calidad y concisa. Gracias a los ultimos avances en el procesamiento de lenguaje natural, es posible procesar y transformar en conocimiento dicha informacion. Sin embargo, todavia se sigue investigando para recuperar la que consideremos de nuestro interes, algo en lo que trabaja la Generacion Automatica de Resumenes. Pero no hay que olvidar que representando la informacion de forma visual somos capaces de comprender y procesar mucho mas rapido. Nuestro sistema puede generar resumenes sobre informes medicos pero intenta ir mas alla proporcionando una interfaz grafica para el tratamiento de dicha informacion asi como su modificacion y personalizacion, intentando facilitar asi la comprension y sintesis de los mismos.
Hexachlorobenzene episode in Turkey.

During the period 1955-1959, approximately 4000 people in southeast Anatolia developed porphyria due to the ingestion of hexachlorobenzene (HCB), a fungicide added to wheat seedlings. These HCB exposures subsequently led to the development of bullae on sun-exposed areas, hyperpigmentation, hypertrichosis, and porphyrinuria. The condition was called kara yara or "black sore. " Many of the breast-fed children under the age of 2 years whose mothers had ingested HCB-treated grain died from a disease known as pembe yara or "pink sore. " In this follow-up study of 252 patients, 20-30 years postexposure, there were 162 males and 90 females, with an average current age of 35.7 years, an average of onset of 7.6 years, and a duration of 2.2 years. Many patients had dermatologic, neurologic, and orthopedic symptoms and signs. The observed clinical findings include scarring of the face and hands (83.7%), hyperpigmentation (65%), hypertrichosis (44.8%), pinched facies (40.1%), painless arthritis (70.2%), small hands (66.6%), sensory shading (60.6%), myotonia (37.9%), cogwheeling (41.9%), enlarged thyroid (34.9%), and enlarged liver (4.8%). Urine and stool porphyrin levels were determined in all patients, and 17 have at least one of the porphyrins elevated. A total of 56 specimens of human milk obtained from mothers with porphyria were analyzed for HCB. The average value was 0.51 ppm in HCB-exposed patients compared to 0.07 ppm in unexposed controls. Offspring of mothers with three decades of HCB-induced porphyria appear normal.
Visual hallucinations during visual recovery after central retinal artery occlusion.

BACKGROUND Charles Bonnet syndrome is characterized by complex, formed visual hallucinations that occur in patients without psychiatric disorders. To the best of our knowledge, it has not been described following central retinal artery occlusion. OBJECTIVE To describe 2 patients who experienced formed visual hallucinations characteristic of Charles Bonnet syndrome after sudden, severe visual loss precipitated by central retinal artery occlusion. PATIENTS Two patients, aged 77 and 63 years respectively, experienced sudden deterioration of vision following central retinal artery occlusion. Formed visual hallucinations occurred in patient 1 six days later and in patient 2 two days later. RESULTS The hallucinations appeared both within and at the borders of the patients' residual intact visual fields. They occurred during periods when the patients experienced partial visual recovery associated with enlargement of their visual fields. The visual recovery and hallucinations both ceased at the same time. CONCLUSIONS We propose that the hallucinations are likely the result of deafferentation and their occurrence during visual recovery suggests that they are a correlate of visual system plasticity.
Serological titres to Leptospira fainei serovar hurstbridge in human sera in Australia

A set of 723 diagnostic sera from human patients, submitted for the microscopic agglutination test (MAT) for antibodies to a group of 6 leptospiral serovars, was also tested by MAT for antibodies to the recently-discovered Leptospira fainei serovar hurstbridge. MAT titres of [ges ]128 to serovar hurstbridge were detected in 13·4% of these sera, and titres of [ges ]512 in 7·2%. In contrast, none of 62 sera obtained from a control population of laboratory staff gave titres of [ges ]128. The difference between the number of titres of [ges ]128 given by the two groups of sera was highly significant (P<0·01). The titres observed may have been due to cross-reactions with other leptospiral serovars, but this could not be demonstrated. An alternative explanation is that serovar hurstbridge is present in the human population.
Distributed Genetic Algorithm for Integrated Process Planning and Scheduling Based on Multi Agent System

Abstract Process planning and scheduling are two crucial functions in manufacturing systems which are usually carried out sequentially. The scheduling is totally based on the outcomes of process planning, and the process planning may be restricted by manufacturing resources. Hence, conducting the process planning and scheduling separately is much likely to ruin the feasibility and optimality of both process planning and scheduling functions. The integration of process planning and scheduling (IPPS) is therefore fairly important for an efficient manufacturing system. In this paper, a distributed genetic algorithm (DGA) is suggested to cater for the IPPS problems domains, and the multi-agent system (MAS) is adopted to accommodate the algorithm. Here it is called the MAS-DGA system. Due to good properties of the MAS, a new agent-based architecture is proposed to accommodate subpopulations, support the traditional GA and provide channels for individuals' immigration. Furthermore, an negotiation mechanism is provided to support bilateral selections between individuals and subpopulations. Benchmark problems have been tested in the experiments, and the results are compared with a symbiotic evolutionary algorithm (SEA) and a cooperative co-evolutionary genetic algorithm (CCGA), which reveals that the proposed MAS-DGA system is feasible and efficient for the resolve of IPPS problems.
Volterra system identification under maximum correntropy criteria in impulsive environments

Since the algorithms derived by maximum error correntropy criterion (MCC) can achieve better performance when the background noise containing non-Gaussian interference, it has been received increasing attention in recent decades. The maximum correntropy criterion is incorporated in second-order volterra (SOV) adaptive filtering in this paper. Then, a novel second-order volterra algorithm which is derived from maximum correntropy criteria is proposed, which is called MCC-SOV. Since using maximum correntropy criteria, the proposed algorithm can achieve better performance under impulsive environment.
Genetic and Environmental Influences on Parent–Child Conflict and Child Depression Through Late Adolescence

Few studies have investigated potential gender differences in the genetic and environmental influences on the prospective associations between parent–child conflict and later depression, a notable gap given substantial gender differences in rates of depression and suggestive evidence of differences in the etiology of depression among females and males. To fill this gap, we evaluated whether the prospective relationship between parent–child conflict and major depressive disorder symptoms varied as a function of parent–child gender composition. A combined twin and adoption sample was used (53% female; 85% European ancestry), containing 1,627 adolescent sibling pairs (789 monozygotic twin pairs, 594 dizygotic/full-biological pairs, 244 genetically unrelated pairs) with assessments at two time points in adolescence (approximate ages 15 and 18). Prospective associations between parent–child conflict and subsequent adolescent depression were explained predominately through common genetic influences for mother–daughter and mother–son pairs but less so for father–daughter and father–son pairs. Results support the notion that processes of gene–environment correlation involved in the prospective associations between parent–child conflict, and later adolescent depression appear to be less relevant to father–child relationships in comparison to mother–child relationships. Notably, results did not show that parent–child conflict was more relevant to the etiology of major depressive disorder (MDD) for girls than boys; gender differences in depression do not appear to be due to differences in the associations between parent–child conflict and child depression.
Belief Revision, Self-Construction and Systemic Certainty

L’influence des processus engages dans l’elaboration personnelle d’une relation conditionnelle (si P alors Q) sur la revision des croyances est examinee ici au moyen d’un systeme d’auto presentation segmentee implemente sur ordinateur. A certains sujets, il etait dit que la relation si P alors Q etait toujours vraie ; aux autres, il leur etait propose d’explorer le systeme afin qu’ils etablissent par eux-memes cette meme relation, avec un degre de certitude tres eleve. Les resultats montrent que les sujets revisent plus leur croyance en la relation conditionnelle lorsque cette croyance leur est imposee que lorsqu’ils ont a l’elaborer. Et malgre le fait que l’on observe un degre tres eleve de certitude de la croyance issue de cette elaboration, la revision de cette croyance parait tres nettement dependre (1) du nombre de fois qu’a ete exploree la relation conditionnelle, et (2) du nombre de fois qu’a ete explore l’unique element qui variait dans le systeme. Ces resultats suggerent que la certitude est une construction a plusieurs niveaux qui implique une evaluation des parametres du systeme dans lequel une croyance est issue.
Eosinophilic inflammation in asthma.

BACKGROUND AND METHODS The importance of eosinophils in the pathogenesis of bronchial asthma is not established. In an attempt to evaluate the role of eosinophilic inflammation in asthma, we compared 10 normal subjects with 43 patients with chronic asthma, 19 of whom had severe disease as assessed by a clinical scoring method described by Aas and by pulmonary-function tests. Eosinophils were counted in peripheral blood and bronchoalveolar-lavage fluid, and in biopsy specimens obtained from the patients and post mortem from 8 subjects without asthma, but not from the 10 normal controls. Eosinophil cationic protein was titrated by radioimmunoassay in the bronchoalveolar-lavage fluid from all subjects and studied by immunohistochemistry in the biopsy specimens. RESULTS There was a significant increase in the number of peripheral-blood eosinophils in the patients that was correlated with the clinical severity of asthma (P less than 0.001) and pulmonary function (P less than 0.03). Levels of eosinophils and eosinophil cationic protein were increased in the bronchoalveolar-lavage fluid from the patients and were also correlated with the severity of asthma (P less than 0.001 and P less than 0.002, respectively). Hematoxylin-eosin staining of bronchial-biopsy specimens showed that intraepithelial eosinophils were present only in patients with asthma. Immunohistochemical analysis of eosinophil cationic protein revealed that normal subjects had only a few nondegranulated eosinophils deep in the submucosa, whereas all the patients had degranulated eosinophils beneath the basement membrane and among epithelial cells. In some patients there was a relation between the presence of degranulated eosinophils and epithelial damage. CONCLUSIONS Eosinophilic inflammation of the airways is correlated with the severity of asthma. These cells are likely to play a part in the epithelial damage seen in this disease.
Activating mutations of the stimulatory G protein in the McCune-Albright syndrome.

BACKGROUND The McCune-Albright syndrome is a sporadic disease characterized by polyostotic fibrous dysplasia, café au lait spots, sexual precocity, and hyperfunction of multiple endocrine glands. These manifestations may be explained by a somatic mutation in affected tissues that results in activation of the signal-transduction pathway generating cyclic AMP (cAMP). We analyzed DNA from tissues of patients with the McCune-Albright syndrome for the presence of activating mutations of the gene for the alpha subunit of the G protein (Gs alpha) that stimulates cAMP formation. METHODS Genomic DNA fragments encompassing regions (exons 8 and 9) previously found to contain activating missense mutations of the Gs alpha gene (gsp mutations) in sporadically occurring pituitary tumors were amplified in tissues from four patients with the McCune-Albright syndrome by the polymerase chain reaction. The amplified DNA was analyzed for mutations by denaturing gradient gel electrophoresis and allele-specific oligonucleotide hybridization. RESULTS We detected one of two activating mutations within exon 8 of the Gs alpha gene in tissues from all four patients, including affected endocrine organs (gonads, adrenal glands, thyroid, and pituitary) and tissues not classically involved in the McCune-Albright syndrome. In two of the patients, histidine was substituted for arginine at position 201 of Gs alpha, and in the other two patients cysteine was substituted for the same arginine residue. In each patient the proportion of cells affected varied from tissue to tissue. In two endocrine organs, the highest proportion of mutant alleles was found in regions of abnormal cell proliferation. CONCLUSIONS Mutations within exon 8 of the Gs alpha gene that result in increased activity of the Gs protein and increased cAMP formation are present in various tissues of patients with the McCune-Albright syndrome. Somatic mutation of this gene early in embryogenesis could result in the mosaic population of normal and mutant-bearing tissues that may underlie the clinical manifestations of this disease.
Early predictive value of non-response to docetaxel in neoadjuvant chemotherapy in breast cancer using 18F-FDG-PET.

BACKGROUND The aim of this prospective study of patients with breast cancer was to identify non-responders to docetaxel in neoadjuvant chemotherapy (NCT) using fluorine-18-fluorodeoxyglucose positron-emission tomography ((18)F-FDG-PET). PATIENTS AND METHODS We analyzed the maximum standardized uptake value (SUVmax) of (18)F-FDG-PET before and after the first course and the reduction rate in tumor size shown by magnetic resonance imaging (MRI) before the first and after the fourth course of docetaxel. RESULTS None of the eight patients (0%) whose SUVmax decrease was less than 18% revealed a clinical partial response or clinical complete response; Seven out of the sixteen patients (44%) with an SUVmax decrease over 45% achieved a complete response. CONCLUSION An SUVmax reduction rate less than 18% is observed in patients with breast cancer after the first course of docetaxel in NCT and may be indicator of non-response to docetaxel.
Tibetan word sense disambiguation based on a semantic knowledge network diagram

The method based on semantic knowledge is the most dynamic research direction in rule-based techniques. This method has been proven effective in studying English and Chinese word sense disambiguation. This study proposes two methods for selecting the correct Chinese meaning of Tibetan ambiguous words from Tibetan sentences in Tibetan-Chinese parallel corpora using semantic knowledge from HowNet and translation information from the aforementioned corpora. We can use these methods to build TibetanChinese parallel corpora with word sense tagging. The two proposed methods are 1) the word sense disambiguation method based on HowNet and Tibetan-Chinese parallel corpora, and; 2) the semantic knowledge-based method of network diagram word sense disambiguation.