Miracle-dz/UniFAR-FTUs huggingface dataset:
CONGENITAL MALFORMATIONS INDUCED IN RATS BY MATERNAL NUTRITIONAL DEFICIENCY: II. USE OF VARIED DIETS AND OF DIFFERENT STRAINS OF RATS

The appearance of congenital malformations in the offspring of female rats reared and bred on a deficient diet has been described previously. 1 The deficient diet referred to is essentially the Steenbock and Black diet 2965 2 supplemented with viosterol in oil to forestall the development of rickets. This diet, which we call diet 1, has the following percentage composition: yellow corn meal, 76; wheat gluten, 20; chemically pure calcium carbonate, 3, and chemically pure sodium chloride, 1. Sixty U. S. P. units of vitamin D (as viosterol in oil) was administered to each female by pipet every tenth day. Up to the time of writing this report the offspring obtained on this diet consist of 761 young. Five hundred and seventeen of these have been normal and 244 (32 per cent) abnormal. The abnormalities were frequently recognized on external inspection (fig. 1). The defects of the skeletal system, which
A new approach to gene prediction, based on the self-organising map

In the present scenario, gene prediction methods use only one model to represent protein-coding regions in a genome, and so the chances of predicting the location of genes that have a typical sequence composition is rare. It is predicted that future improvements in gene finding will be based on various methods of development that can adequately deal with intra-genomic compositional variation. This work explores a new approach to gene prediction, based on the self-organising map (SOM), which has the ability to automatically identify multiple gene models within a genome. The current implementation, named codon usage information (CUI), uses relative synonymous codon usage (RSCU) as the indicator of protein-coding potential. Though the raw accuracy rate is considered less than other methods, CUI consistently identifies some genes that other methods do not, and should therefore be of interest to gene prediction software developers and people working on genome annotation. CUI is recommended for use in conjunction with, or as a complement to, other gene prediction methods.
Study of the Cytotoxicity of a Composite of Carboxymethylcellulose (CMC) and a BioCeramic (Biphasic Calcium Phosphate-BCP) Injection for Use in Articular Cartilage Repair

The failure of organs and tissues caused by trauma and other injuries is one of the most costly of human health problems. It is estimated that 1.6 million people experience work limitations caused by osteoarthritis and related disorders, representing 8.3% of all main conditions. Joint injuries frequently lead to progressive joint degeneration and post-traumatic osteoarthritis. Articular cartilage has only a limited capacity for self-healing, mainly due to the fact that it is avascular; and once seriously damaged, articular cartilage lesions will not regenerate. There is strong evidence that cartilage lesions may lead to osteoarthritis when left untreated. Numerous animal experiments and clinical studies have shown that early biological reconstruction of circumscribed cartilage defects in the knee is superior to conservative or delayed surgical treatment. Tissue engineering has shown promising therapeutic strategies for repair or regeneration of damaged tissues. Currently, ceramic based and polymeric scaffolds have been developed to bring about the restoration of tissue functions. The bioceramics associated with water-soluble polymers have been developed as substitutes for various orthopedic applications. The objectives of this work are the processing and characterization of a composite of carboxymethylcellulose (CMC) and biphasic calcium phosphate (Biphasic Calcium Phosphate - BCP) in the form of a hydrogel, and a study of its cytotoxicity (in vitro), aimed at its application as an injectable biomaterial in order to repair the extracellular matrix of articular cartilage. The CMC and BCP were characterized by Fourier Transform Infrared Spectrometry (FTIR) and X-Ray Diffraction (XRD), X-ray fluorescence (XRF), respectively, and scanning electron microscopy (SEM) of powders and the composite. To evaluate the biological effect of the composite hydrogel, tests of cytotoxicity (MTT) and rheological tests under real conditions of use were performed. The composite of carboxymethylcellulose (CMC) and bioceramics (biphasic calcium phosphate-BCP) in the form of hydrogel showed an adequate injectability in the conditions studied, and a non-toxic response, presenting potential for use as fillers or to stimulate the healing of cartilage defects in the extracellular matrix of articular cartilage.
Development of EEG data acquisition device by using single board computer

Electroencephalogram (EEG) plays a vital role in several medical diagnosis (brain tumour detection, Alzheimer disease, epilepsy, etc.), engineering applications (emotion detection, drowsiness detection, stress assessment, etc.) and others. However, the cost of the EEG device is usually high (< $20,000) and it is still a challenging issue for many consumers. The cost of the EEG data acquisition device purely depends on number of EEG channels, mode of signal transmission (wired/wireless), data resolution, software portability, etc. In recent years, the development of handy embedded systems opens a gateway to design and develop the data acquisition devices at a cheaper cost. In this work, we have used SBC TS 7800 (500 MHz, 128 MB RAM) for designing the EEG wired data acquisition device. This embedded system is used to acquire the data from the 32 EEG channels and to save the them in American Standard Code for Information Interchange (ASCII) values in either . txt or xls format for further research investigations. All the EEG channels are made up of Ag/Ag-Cl and have an impedance of 10 kΩ. This complete system is operating in Linux platform, and programs are developed using C and JAVA programming languages.
Toward Everyday Ethics: Strategies for Shifting Perspectives

Jane, a nurse in the cardiac intensive care unit, is caring for a patient during an overnight shift when the patient’s blood pressure starts to drop. The patient’s mean arterial pressures are consistently low and the hypotension does not improve with fluid resuscitation. The resident on call makes the decision to start a norepinephrine drip; however, the patient only has peripheral intravenous (IV) lines. Jane lets the resident know that the patient will need a central line as per hospital policy. The resident tells Jane that he does not want to wake up the attending physician and that infusing the norepinephrine peripherally is an acceptable course of action. Jane is not sure how to proceed but does not discuss the issue further with the resident. She is uncomfortable with his decision and is concerned that infusing the norepinephrine through a peripheral IV puts her patient at risk for a dangerous infiltration and extravasation. She knows that a central line would be safer and that her hospital’s policy requires it; however, Jane is unsure whether calling the attending physician herself would be appropriate. Not wanting to cause trouble with the resident, Jane decides to let it go and continues the norepinephrine infusion through the peripheral IV for the rest of the night.
Intratympanic injection in delayed endolymphatic hydrops

Abstract Conclusions: The present study showed that intratympanic dexamethasone injection (ITD) is a promising approach for the treatment of contralateral and ipsilateral delayed endolymphatic hydrops (DEH). Moreover, intratympanic gentamicin injection (ITG), as a chemical labyrinthectomy, is a simple alternative for controlling vertigo in patients with ipsilateral DEH. Objective: This study examined the effect of ITD or ITG on DEH. Methods: Fourteen patients with DEH completed the clinical and audio-vestibular evaluation. Among them, 10 cases (ipsilateral type: nine cases, contralateral type: one case) were treated with intratympanic injection. Four patients with ipsilateral DEH underwent ITG, five patients with ipsilateral type and one patient with contralateral type received ITD. All 10 cases were followed up for 8–48 months. Results: Complete and substantial vertigo control was achieved in four of nine ipsilateral DEH patients treated with ITG. In the other five ipsilateral cases who received ITD, two accomplished complete vertigo control and two had substantial control. In one case, the vertigo was not effectively controlled. One case of contralateral DEH underwent ITD and this case had complete vertigo control. The vertigo intensity, vertigo frequency, vertigo duration and the functional level scale after intratympanic injection was decreased significantly.
Advanced Prostate Cancer Survivors: Implications for Palliative Care

Introduction: Men with long term advanced cancer of the prostate can be considered transitional cancer survivors because many have complex physical, emotional, and psychosocial needs that extend beyond the active treatment period. Methods: Health care providers completed a survey identifying the needs most common to men with advancedprostate cancer. Descriptive statistics were used to describe the sample and analyze the survey data, including means for continuous variables and frequencies for categorical variables. Qualitative content analysis was used to analyze the cancer-related topics suggested by the respondents that were not included in the questionnaire. Results: Thirty providers completed the survey. Mean age of respondent was 46.8 years. The majority of participants reported that their race was White, indicated that they were physicians, and reported that they practiced in outpatient or ambulatory care settings. The respondent’s mean years in the current clinical role, current clinical setting and experience with people with advanced cancer was 17.8 years, 11.0, and 17.3, respectively. The needs identified by the respondents as important (listed from highest to lowest frequency) were help with decisions (92%), help with hands-on care (88%), and referral to community resources (88%), financial assistance (85%), help with anxiety or depression (85%), help with grieving (77%), and help with an advanced directive (73%). The needs that least likely to be addressed by the health care providers in their clinical settings were financial assistance (95%), spiritual care (84%), and help with grieving (58%). Discussion: While community-based physician practices are able to address the direct physical needs, they may have limited ability to provide emotional, spiritual or financial support that are needed by families. Given the large and growing number of long-term survivors, the time has come to develop comprehensive plans of care that integrate palliative care principles throughout all phases of the cancer journey.
On emergent complex behaviour, self-organised criticality and phase transitions in multi-agent systems: autonomy oriented computing (AOC) perspectives

In a Multi-Agent System (MAS), there usually exist system-level goals that agents are collectively trying to attain. Generally speaking, the local behaviours and performances of individual agents directly determine which global characteristics of an MAS, for example, the global performance and/or patterns, will emerge and how the system-level goals will be attained. In most cases, such a local? global relationship is neither obvious nor straightforward. In this paper, we will address several issues on modelling emergent complex behaviours in MAS. In particular, we will focus on the local? global relationship in a Self-Organising MAS (SOMAS), and discuss the phenomena of Self-Organised Criticality (SOC) and phase transition in SOMAS.
systematic review-meta-analysis and meta-regression on he effect of selected competitive exclusion products on almonella spp . prevalence and concentration in broiler hickens

The effectiveness of various competitive exclusion (CE) products for reducing Salmonella colonization in broiler chickens was evaluated using systematic review-meta-analysismeta-regression (SR-MA-MR). Relevance screening identified 201 relevant studies that were subjected to methodological assessment. Of these studies, 159 were suitable for data extraction, 66 were presented in a number of MAs and 130 were examined in a meta-regression (MR). Fourteen different CE products were identified, 9 of them commercial products, and the most common route of administration was oral gavage (63.7% of trials). Meta-analyses indicated that a number of CE products reduce Salmonella colonization in broilers, the most effective one being PreemptTM which was formerly known as CF-3. Five study characteristics (publication year, CE type, CE route, sample origin, and Salmonella serovar administered/recovered) and three methodological soundness characteristics (treatment assignment, intervention and laboratory methods description) were retained as statistically significant (p < 0.05) in the final MR model. The MR analysis indicated that, undefined CE products outperformed all commercial products, except for: PreemptTM and Broilact®. Both were considered comparable to the undefined chicken source CE culture products in effectiveness. The administration of CE through spraying the chicks at the hatchery was determined to be just as effective as the oral gavage treatment, and more practical for farmers to administer. The results of this study could be useful in decision-making concerning the on-farm use of CE products in broiler chickens, and as inputs for risk assessments as the industry pushes for more antibiotic-free alternatives. Out of the various interventio the most studied; its inab efficacy remains a barrier ∗ Corresponding author at: Laboratory for Foodborne Zoonoses, 160 Research L ax: +1 519 826 2367. E-mail address: lisa.waddell@phac-aspc.gc. ca (L.A. Waddell). 167-5877/$ – see front matter © 2013 Elsevier B.V. All rights reserved. ttp://dx.doi. org/10.1016/j.prevetmed. 2013.04. 005 ns to reduce Salmonella colonization in broilers on-farm, CE was ility to be licenced in certain countries and proof of consistent . © 2013 Elsevier B.V. All rights reserved. ane Suite 206, Guelph, Ontario, N1G 5B2, Canada. Tel. : +1 519 826 2347; erinary M A.K. Kerr et al. / Preventive Vet
Decitabine for the treatment of acute myeloid leukemia

Introduction: Intensive chemotherapy remains the only therapeutic option that provides a reasonable chance of long-term survival for adults with acute myeloid leukemia (AML), particularly for those younger than 60 years of age. However, the vast majority of patients with AML are older than 60 years and the risks associated with intensive approaches are not only substantially greater but are also associated with significantly lower response rates. While a subset of older adults who are medically fit and have favorable biological features may be suitable candidates for intensive chemotherapy, many older adults are not candidates due to comorbidities, impaired performance status, and/or poor prognosis due to cytogenetic and molecular features. Outside of supportive care, there are limited treatment options that provide durable responses for older patients with AML, thereby warranting the development of novel therapeutic approaches. Decitabine (Dacogen, Astex/Eisai), a nucleoside analog, is FDA approved for the treatment of myelodysplastic syndrome (MDS) and has shown encouraging antileukemic efficacy for the management of older adults with AML. Combined with its favorable side-effect profile, decitabine has been at the center of several trials in the treatment of older adults with AML. Furthermore, decitabine is approved for the treatment of elderly AML in Europe. Areas covered: This paper will discuss the biological and clinical rationale for using decitabine as frontline therapy for AML patients unable to tolerate and/or benefit from intensive chemotherapy. A review of selected published manuscripts and abstracts on the subject of elderly AML and a search of PubMed for manuscripts in English using a combination of index words including AML, decitabine, elderly, hypomethylation, and 2′-deoxy-5-azacytidine was conducted and articles of interest selected. Expert opinion: Conventional treatment strategies for AML have not changed appreciably over the last 40 years. The intensive strategies necessary for attaining long-term survival are best tolerated by individuals younger than 60 – 65 years of age and a subset of medically fit older adults with favorable biological features. Unfortunately, many older adults with AML are medically unfit for intensive therapy due to significant comorbidities or poor functional status. In this setting, epigenetic therapy with hypomethylating agents represents a reasonable approach for the frontline treatment of older patients with AML unwilling or unsuitable for intensive chemotherapy or clinical trial. Decitabine has proven clinical benefits for patients with MDS and more recently in patients with AML. Response rates gained from low-dose decitabine (20 mg/m2 i.v. daily for 5 or 10 days every 28 days) are comparable to more intensive strategies. Compared to other widely accepted low-intensity programs such as low-dose cytarabine (20 mg/m2 subcutaneously once daily for 10 days) and supportive care, the 5-day decitabine regimen provides a modest survival benefit, as well.
Gastrointestinal bleeding and outcomes after percutaneous coronary intervention for ST-segment elevation myocardial infarction.

BACKGROUND Gastrointestinal bleeding is a hemorrhagic complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction (STEMI). OBJECTIVES To determine predictors of gastrointestinal bleeding and the impact of gastrointestinal bleeding on outcomes in STEMI patients undergoing primary percutaneous coronary intervention. METHODS AND RESULTS Gastrointestinal bleeding occurred in 18 (3.5%) of 519 consecutive patients with STEMI undergoing primary percutaneous coronary intervention. Univariate predictors of gastrointestinal bleeding were previous gastrointestinal bleeding (33% vs 4%, P < .001), impaired renal function (89% vs 37%, P<.001), Killip class IV at presentation (61% vs 18%, P<.001), higher peak creatinine kinase level (mean [SD], 3801.6 [3280.2] vs 2721.3 [2286.6] IU/L, P=.05), and mechanical ventilator support (44% vs 12%, P<.001). Coprescription of proton-pump inhibitors did not reduce the risk of gastrointestinal bleeding (22.2% vs 13.4%, P=.22). Multivariate analysis showed an odds ratio (95% confidence interval) for gastrointestinal bleeding of 22.1 (5.6-86.89, P<.001) for previous gastrointestinal bleeding, 6.74 (1.30-34.89, P=.02) for impaired renal function, and 4.68 (1.35-16.2, P=.01) for Killip class IV at presentation. Gastrointestinal bleeding was associated with longer intensive care unit stay (mean [SD], 5.4 [6.7] vs 3.6 [3.6] days, P=.04), and higher in-hospital (44% vs 9%, P<.001) and overall (44% vs 13%, P<.001) mortality rate. CONCLUSIONS Although rare, gastrointestinal bleeding in patients with STEMI significantly prolongs intensive care unit stay and increases mortality. Previous gastrointestinal bleeding, impaired renal function, and Killip class IV at presentation are associated with higher incidence of gastrointestinal bleeding.
Bronchial Asthma, Chronic Obstructive Pulmonary Disease and NF-κB

Respiratory diseases place a considerable burden on global health. Bronchial asthma describes many heterogeneous clinical phenotypes that result in chronic bronchial inflammation. Chronic obstructive pulmonary disease (COPD) is one of the most common adult respiratory disorders characterized by chronic airflow limitation that is not fully reversible and is associated with an abnormal inflammatory response of the lungs to noxious particles and gases. Recognition of the global importance and rising prevalence of these diseases and the absence of effective treatments has led to concerted efforts to improve the efficacy of the existing drugs and develop new ones that target cellular and molecular mechanisms that underlie disease pathogenesis. The transcription factor nuclear factor kappa B (NF-kappaB) regulates the expression of a wide array of genes that are involved in the molecular pathobiology of the lung by regulating cellular immune responses, cell adhesion, differentiation, proliferation, angiogenesis and apoptosis. In this work, we review published clinical and experimental studies that link the inhibition of NF-kappaB activity with the treatment of asthma and COPD. Our end point is to help identify pathway-specific inhibitors of NF-kappaB that can be used for the treatment of specific human ailments.
Postal Work: Work Organizational Changes As Tools to Improve Health

Postal work is performed in very different settings, and the works are e.g., drivers, letter carriers, postal sorters, and counter clerks. A finding that a small group of parcel sorters with a good psychosocial work situation had much lower health complaints than comparable workers with a worse psychosocial situation at work, indicated that it might be possible to improve mental and physical health among postal employees by improving work organization.The theoretical framework for this thesis is the demands-control-support (DCS) model by Karasek, Theorell, and Johnson. Two cross-sectional studies were performed with questionnaires. In a study on 144 workers at a postal terminal it was found associations between low support from superiors and high psychological work demands, on one hand and gastrointestinal and sleep problems on the other. In another study on 655 postal workers in 6 different occupations, high psychological work demands and low skill discretion was associated with low-back pain, and low social support at work with neck pain. In this study, the associations differed significantly between men and women.A follow-up study on the postal terminal (136 persons) was performed 8 and 12 months after an organizational change took place. The changes were aimed at improving the shift system, and psychosocial work situation. Authority over decision and skill discretion increased, and sick-leave decreased during the follow up period. Changes in contact with superiors, team-mates, and skill discretion were associated with changes in gastrointestinal and sleep complaints. In another follow up study, 82 individuals were studied before and 1 year after improvement of the psychosocial work environment. Musculoskeletal complaints were significantly reduced in the intervention group but not in the control group. Increased support from superiors was associated with less symptoms. Younger age and higher authority over decisions at baseline was associated with reduced symptoms at follow-up.The main findings of this thesis are that there are significant associations between psychosocial work situation among postal workers and psychosomatic and musculoskeletal symptoms, and that it is possible to reduce symptoms and sick-leave, by changes of organization, and improvement of the psychosocial work situation