Miracle-dz/UniFAR-FTUs huggingface dataset:
5-Benzoyl-2-(1H-indol-3-yl)-4-[4-(propan-2-yl)phenyl]-4,5-dihydrofuran-3-carbonitrile

In the title compound, C29H24N2O2, the hydrofuran ring is twisted with puckering parameters Q = 0.1553 (16) Å and ϕ = 305.0 (6)°. In the crystal, the graph-set motifs of the interaction pattern are an R 2 2(16) motif involving dimers through N—H⋯N hydrogen bonds across centres of inversion and a C(6) motif through C—H⋯O hydrogen-bond between glide-related molecules. Together, these generate [101] ladder-like chains.
Query-by-Pictorial-Example

Query-by-Pictorial-Example is a relational query language introduced for manipulating queries regarding pictorial relations as well as conventional relations. In addition to the manipulating capabilities of the conventional query languages, queries can also be expressed in terms of pictorial examples through a display tenninal. Example queries are used to illustrate the language facilities.
(±)-3-Carboxy-2-(imidazol-3-ium-1-yl)propanoate

The title compound, C7H8N2O4, crystallizes as a zwitterion, with molecules organized into molecular sheets via carboxyl–carboxylate and N+—H⋯carboxylate contacts. These sheets are constructed from translationally related molecules that further link to neighboring motifs via π-stacking [centroid–centroid distance 3.504 (3) Å] and weak C—H⋯O contacts.
2,2′-(9,9-Dioctyl-9H-fluorene-2,7-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

In the title compound, C41H64B2O4, one of the five-membered rings has an envelope conformation, while the other, which may be affected by disorder, is nearly coplanar with the fluorene ring. The dihedral angle between the fluorene and dioxaborolane rings is 2.29 (1)°. Two of the methyl groups are disordered over two orientations in 0.67 (3):0.33 (3) and 0.568 (10):0.432 (10) ratios.
Canadian Urologic Oncology Group (CUOG) phase II multi-center study using docetaxel/prednisone in the second line setting for metastatic hormone-refractory prostate cancer in patients progressing after first line mitoxantrone/prednisone

4612 Background: Until recently the standard approved regimen for symptomatic HRPC has been mitoxantrone/prednisone (MP). The regimen has proven efficacy in pain reduction and improvement in quality of life but has not shown survival benefit. No standard chemotherapy has been approved in the second line setting. Prior to the reporting of the phase 3 results of Tax 327 and SWOG 9916, phase II data showing efficacy with docetaxel/prednisone (DP) led to considering DP in patients progressing after prior MP and was the rational for this study. Objectives: Determine the tolerabilty and response to docetaxel 75mg per square meter every 3 weeks and prednisone 5mg BID in the second line setting in patients with metastatic HRPC having progressed after first line MP. Methods: Thirty patients (30) from 4 centers have been entered in the study. All patients had had prior MP for symptomatic, metastatic HRPC. Baseline PSA, pain scores, analgesic scores, bone scan and CT of the abdomen and chest were obtained. Patients .
4,4′,6,6′-Tetrachloro-2,2′-[(1E,1′E)-propane-1,3-diylbis(nitrilomethanylylidene)]diphenol

The title compound, C17H14Cl4N2O2, is generated by crystallographic twofold symmetry. The two benzene rings are inclined to one another by 80.17 (10)°. There are two intramolecular O—H⋯N hydrogen bonds, which make S(6) ring motifs. In the crystal, molecules are linked by C—H⋯O and weak C—H⋯Cl interactions, forming a three-dimensional network.
(E)-4-Amino-N′-(2-hydroxy-5-methylbenzylidene)benzohydrazide

The asymmetric unit of the title compound, C15H15N3O2, comprises two crystallographically independent molecules (A and B), each having an E conformation around the C=N bond. In each molecule, there is an intramolecular O—H⋯N hydrogen bond making an S(6) ring motif. The dihedral angles between the substituted phenyl rings are 17.49 (9) and 10.03 (9)°. In the crystal, N—H⋯O hydrogen bonds link neighbouring independent molecules into infinite chains, of the type –A–B–A–B–, along the a axis, enclosing R 2 1(7) ring motifs. The chains are linked by N—H⋯O hydrogen bonds and C—H⋯O interactions, leading to the formation of a three-dimensional network.
Beta-adrenolityk z antagonistą kanału wapniowego jako nowy lek złożony w terapii hipotensyjnej — stanowisko ekspertów

Zlozone leki hipotensyjne stanowią istotny element terapii nadciśnienia tetniczego ze wzgledu na dodatkowe korzyści, jakie przynoszą w zakresie wytrwalości terapeutycznej i stopnia wspolpracy pacjenta z lekarzem. W nadciśnieniu tetniczym 2 stopnia są podstawową opcją terapeutyczną. Dostepne dotychczas w Polsce preparaty zlozone zawieraly lek blokujący uklad renina–angiotensyna. Bisoprolol z amlodipiną stanowi nowy typ polączenia lekow hipotensyjnych w preparacie zlozonym. W tym wypadku mamy do dyspozycji skojarzenie w jednej tabletce nowoczesnego beta-adrenolityku kardioselektywnego z najpopularniejszym dihydropirydynowym antagonistą wapnia. Oba leki cechuje dlugi okres dzialania i korzystne wyniki duzych prob klinicznych z ich udzialem. Ponadto leki te wykazują odmienne mechanizmy dzialania hipotensyjnego, co zapewnia skutecznośc hipotensyjną niezaleznie od wieku pacjenta i jego aktywności reninowej osocza. Korzystny wplyw amlodipiny na ciśnienie centralne niweluje ewentualną mniejszą efektywnośc obnizania tego istotnego parametru hemodynamicznego przez bisoprolol. Wynik badania oceniającego bezpośrednio preparat zlozony bisoprolol–amlodipina wykazal jego wysoką skutecznośc obnizania ciśnienia tetniczego i jednoczesne zwolnienie czynności serca. Leczenie bylo bardzo dobrze tolerowane przez 90% pacjentow. W polskim rejestrze ankietowym BETAMLO obejmującym ponad 13 000 pacjentow bisoprolol i amlodipina byly najcześciej wybieranymi lekami w grupie, odpowiednio b-adrenolitykow i antagonistow wapnia, a najpopularniejsze dawka to 5 mg/5 mg. Naturalne wskazanie dla polączenia bisoprololu z amlodipiną to nadciśnienie tetnicze 2 stopnia u pacjentow mlodych, ktorzy nie wymagają blokady ukladu renina–angiotensyna (RA). Szczegolnie dotyczy to kobiet w tej grupie wiekowej, gdzie ze wzgledu na mozliwośc, a czasem planowanie zajścia w ciąze leki blokujące uklad RA są przeciwwskazane. W nadciśnieniu tetniczym powiklanym chorobą niedokrwienną serca, po przebytym incydencie wiencowym polączenie bisoprololu z amlodipiną moze byc z powodzeniem stosowane lączenie z inhibitorem konwertazy angiotensyny, szczegolnie w razie konieczności intensyfikacji leczenia hipotensyjnego lub przeciwdlawicowego za pomocą trzech lekow. Podobnie u pacjentow z nadciśnieniem i towarzyszącą cukrzycą.
Mass Tertiary Education in the Developing World: Distant Prospect or Distinct Possibility?

In the coming decades the global profile of tertiary education will be transformed by the multiplication and growth of institutions in the developing world. Age participation rates in tertiary education are below 10% in many poorer countries. To achieve the rate of 35% considered the threshold for 'developed' status these countries will greatly expand forms of provision that are marginal in richer countries today: private for-profit institutions, distance learning, and cross-border operations. When today's developing countries account for the majority of college students, tertiary education worldwide will look even more diversified as commercial providers adopt the systems and technologies of production and service industries. With appropriate international safeguards and national regulation, however, the benefits to individuals of this global expansion of access of tertiary education will outweigh any concerns that higher learning is losing its soul in a huge marketplace.
3β-Acetoxy-12α-chloro-d-friedooleanan-28,14β-olide

The title compound, C32H49ClO4, was obtained along with nitrile and lactam products in the POCl3-catalysed Beckmann rearrangement from 3β-acetoxy-12-hydroxyiminoolean-28-olic acid methyl ester. The mechanism of the transformation leading to the title compound remains unclear and requires further investigation. Rings A, B and E are in chair conformations, ring C has a twisted-boat conformation, ring D a conformation halfway between boat and twisted-boat and rings D and E are cis-fused. In the crystal, molecules are connected by weak intermolecular C—H⋯O hydrogen bonds into layers extending parallel to the bc plane.
1-[(Pyridin-3-yl)(pyrrolidin-1-yl)methyl]naphthalen-2-ol

The title compound, C20H20N2O, was synthesized by a solvent-free one-pot three-component domino reaction of naphthalen-2-ol, nicotinaldehyde and pyrrolidine. The dihedral angle between the naphthalene ring system and the pyridine ring is 74.22 (6)°. The pyrrolidine ring assumes an envelope conformation with the N atom as the flap. An intramolecular O—H⋯N hydrogen bond stabilizes the molecular conformation.
Poly[diaqua-μ4-biphenyl-4,4′-dicarboxylato-magnesium(II)]

The solvothermal reaction of magnesium nitrate with biphenyl-4,4′-dicarboxylic acid in N,N-dimethylformamide and water leads to the formation of crystals of the title complex, [Mg(C14H8O4)(H2O)2]n. In the crystal structure, the Mg cations are coordinated by six O atoms from two water molecules and four symmetry-related biphenyl-4,4′-dicarboxylate anions within slightly distorted octahedra. The Mg cations are located on a center of inversion, the biphenyl-4,4′-dicarboxylate anions around a twofold rotation axis and the water molecule in a general position. The Mg cations are linked by the anions into a three-dimensional framework.
4-Acetyl-3,3-diethyl-5-hydroxy-2-morpholino-2,3-dihydro-1-benzofuran

In the title compound, C18H25NO4, the benzofuran ring is almost planar and the morpholino ring displays a chair conformation. The packing of compound has a one-dimensional structure constructed through intermolecular O—H⋯O hydrogen bonds. The conformation is stabilized by intramolecular C—H⋯N and C—H⋯O interactions.
1-Azido-N′-(phenylsulfonyl)methanimidamide

In the title compound, C7H7N5O2S, the aromatic ring is oriented at dihedral angles of 79.46 (2) and 89.17 (2)°, respectively, with respect to the amino(azido)methyl and the S(6) six-membered ring motif generated by an intramolecular N—H⋯O interaction [N⋯O = 2.8901 (15) Å]. Intermolecular N—H⋯O hydrogen bonds [N⋯O = 2.9177 (15) and 2.9757 (15) Å] generate an infinite one-dimensional network along the base vector (010).
Naphthalene-2,3-diylbis[(2-thienyl)methanone]

The asymmetric unit of the title compound, C20H12O2S2, contains two crystallographically independent molecules which differ in the orientations of thienylmethanone units with respect to the naphthalene ring system [dihedral angles of 65.30 (11) and 50.94 (11)° in one molecule, 41.94 (12) and 69.61 (13)° in the other]. The crystal structure is stabilized by C—H⋯O and C—H⋯π interactions.
1-[3-(Morpholin-4-yl)propyl]-3-[(naphthalen-2-yl)oxy]-4-(3-nitrophenyl)azetidin-2-one

In the title compound, C26H27N3O5, the β-lactam (azetidin-2-one) ring is nearly planar [maximum deviation = 0.011 (3) Å]. The mean plane formed by the four C atoms of the morpholine ring, which adopts a chair conformation, the benzene ring and the naphthalene ring system form dihedral angles of 72.85 (17), 87.46 (15) and 65.96 (11)°, respectively, with the β-lactam ring. In the crystal, molecules are linked via C—H⋯O hydrogen bonds, forming inversion dimers with R 2 2(8).
Dibromidobis(4-hydroxy-1,5-dimethyl-2-phenyl-3-pyrazolone)zinc(II)

In the title compound, [ZnBr2(C11H12N2O2)2], the Zn(II) ion is coordinated by two Br atoms and two O atoms from two 4-hydroxyantipyrine molecules via the carbonyl O atoms, which act as monodentate ligands, giving rise to a distorted tetrahedral geometry. The values of the bond angles at the Zn atom are in the range 99.4 (1) to 113.2 (1)°. The presence of O—H⋯O and O—H⋯Br intramolecular hydrogen bonds can explain the difference between the two Zn—O [1.961 (3)/2.015 (3) Å] and the two Zn—Br [2.350 (1)/2.378 (1) Å] bond lengths. The crystal structure is governed by C—H⋯O, C—H⋯Br and Zn—Br⋯Cg(π-ring) interactions.
4-Allyl-3-(2-methyl-4-quinolyl)-1H-1,2,4-triazole-5(4H)-thione

In the title compound, C15H14N4S, the quinoline and triazole rings form a dihedral angle of 41.48 (7)°. In the crystal, adjacent molecules are linked by N—H⋯N hydrogen bonds, forming chains along [100].
Le tissu adipeux: un véritable organe endocrine

Le tissu adipeux est un veritable organe endocrine qui Joue un role crucial dans la regulation de la balance energetique ainsi que dans la mediation des complications metaboliques et cardiovasculalres associees a l'obesite. Parmi les nombreuses substances secretees par les adlpocytes, l'anglotenslnogene et l'angiotensine II, l'inhibiteur de l'activateur du plasminogene 1, l'adiponectine et la resistine semblent participer a la pathogenese de l'hypertension, des accidents thrombotiques et de la resistance a l'Insuline associee a l'exces de graisse viscerale. De plus, l'activite augmentee de la 11β-hydroxysteroide deshydrogenase de type 1 dans le tissu gras visceral contribue tres activement a la presence de hautes concentrations de cortisol dans ce tissu, participant ainsi a la distribution de la graisse de l'organisme et aux risques cardiovasculaires. Toutes ces observations devraient permettre le developpement prochain de nouvelles strategies dans le traitement de l'obesite et de ses comorbidites.
1,5‐Dimethyl‐4‐[2‐(methylsulfanyl)benzylideneamino]‐2‐phenyl‐1H‐pyrazol‐3(2H)‐one

In the title compound, C19H19N3OS, a Schiff base, there are three different intra­molecular hydrogen bonds (C—H⋯O and C—H⋯S), which stabilize the structure; this is further extended into one-dimensional chains parallel to the a axis via inter­molecular hydrogen bonds.
1-Benzyl-2,5-diphenyl-3-tosylimidazolidin-4-one

In the title compound, C29H26N2O3S, the central imidazolidine ring adopts an envelope conformation with the N atom bearing the benzyl ring at the flap. The S atom has distorted tetrahedral geometry. The benzyl and tosyl rings are oriented at a dihedral angle of 52.1 (1)°. The phenyl rings connected to the imidazolidine ring form a dihedral angle of 28.7 (1)°.
4-[(E)-(2,3-Dichlorobenzylidene)amino]phenol

In the title compound, C13H9Cl2NO, the dihedral angle between the benzene rings is 54.22 (10)°. In the crystal, molecules are linked by O—H⋯N intermolecular hydrogen bonds, forming a zigzag C(7) chain along the a axis.
14-(1,3-Benzodioxol-5-yl)-7,14-dihydrodibenzo[a,j]acridine

The title compound, C28H19NO2, was synthesized by the reaction of 1,3-benzodioxole-5-carbaldehyde with naphthalen-2-amine catalyzed by thiosalicylic acid in acetic acid. The central dihydropyridine ring adopts a boat conformation. The two planar (r.m.s. deviations = 0.0158 and 0.0552 Å) bicyclic parts make a dihedral angle of 16.16 (5)° with respect to each other. The crystal packing is stabilized by intermolecular N—H⋯O hydrogen bonds and C—H⋯π interactions.
EVALUATION OF RENAL FUNCTION IN CERVIX CANCER PATIENTS BY DOSE CISPLATIN 75 mg/m2 WITH NaCl-MANITOL HYDRATION

Cisplatin is one of platinum cytostatic drug for the medication of solid cancers, one of which is cervical cancer. Adverse event thatresulted during drug treatment was acute or chronic nephrotoxicity. A cross sectional, prospective, observational study wasconducted to evaluate the effect of NaCl-Mannitol hydration on urine production and renal function of cervical cancer patientsreceiving cisplatin 75mg/m2. Inclusion criteria were 21 pastients eClCr Cockroft Gault > 60 ml/min of any cycle, receiving 1 L ofNaCl hydration pre chemoteraphy and 1 L of NaCl plus 30 g Mannitol, 20 mEq KCl, and 1 g MgSO4 for post chemoteraphy. Dataobtained were BUN, SrCr, albumin and eClCr calculation (MDRD and Cockroft Gault), each was measured pre and day six posttreatment. Urine production was measured before chemotherapy and 3 and 12 hours post chemoteraphy hydration. Urine productionof total 21 inpatients had reached > 100 mL/hour at 3rd hour post chemotherapy. There were 8 patients (39%) who experiencedacute nephrotoxicity characterized by an increase of serum creatinine by 1.5 times from the baseline. (FMI 2014;50 226-233)
5,6-Dichloro-2-(2-hydroxyphenyl)isoindoline-1,3-dione

In the molecule of the title compound, C14H7Cl2NO3, the phthalimide ring system is virtually planar, with a dihedral angle between the fused five- and six-membered rings of 4.02 (3)°. In the crystal structure, intermolecular C—H⋯O and O—H⋯O hydrogen bonds and C—Cl⋯O close contacts [Cl⋯O = 3.0123 (13) Å and C—Cl⋯O = 171.14 (7)°] link the molecules, generating R 2 2(16), R 4 2(19) and R 4 4(22) ring motifs by C(6) chains to form a three-dimensional network. A weak π–π interaction between the six-membered rings of the phthalimide ring systems further stabilizes the structure, with a centroid–centroid distance of 3.666 (3) Å and an interplanar separation of 3.568 Å.
4-Nitro-N-(8-quinolyl)benzamide

In the title compound, C16H11N3O3, the amide group is twisted away from the plane of the quinoline benzene ring by 3.93 (5)°, but is twisted away from the nitrobenzene ring by 22.68 (4)°. A weak intramolecular C—H⋯O hydrogen bond is observed. In the crystal structure, molecules are linked into a chain along the a axis by intermolecular C—H⋯O hydrogen bonds.
3,4-O-Isopropylidene-2,7-di-O-p-tolylsulfonyl-α-l-xylo-3-heptulo-3,6-furanosononitrile

In the title compound, C24H27NO10S2, derived from l-sorbofuranose, the fused five-membered rings display envelope conformations. The two tosylate branches are in equatorial positions with respect to the furanose ring, while the hydroxy group is in the axial position. In the crystal structure, the hydroxy group is involved in intermolecular O—H⋯O hydrogen bonds, linking molecules in chains along [100].
(E)-1-(1,3-Benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-one

In the molecule of the title compound, C14H16O3, all non-H atoms except for one methyl C atom lie on a crystallographic mirror plane. The conformation with respect to the C=C bond [1.3465 (12) Å] is trans. In the crystal, molecules are linked via C—H⋯O hydrogen bonds into C(5) chains propagating along [100].
6,6′-Dihydroxy-2,2′-[(propane-1,3-diyldioxy)bis(nitrilomethylidyne)]diphenol

The molecule of the title compound, C17H18N2O6, adopts a V-shaped conformation, the dihedral angle between the two halves of the molecule being 81.31 (4) °. There is one half-molecule in the asymmetric unit, with a crystallographic twofold rotation axis passing through the central C atom. There are strong intramolecular O—H⋯N and O—H⋯O hydrogen bonds involving the hydroxy group and adjacent O and N atoms. In the crystal structure, intermolecular O—H⋯O hydrogen bonds link the molecules, forming an infinite three-dimensional supramolecular structure.
Spatial-bag-of-features

In this paper, we study the problem of large scale image retrieval by developing a new class of bag-of-features to encode geometric information of objects within an image. Beyond existing orderless bag-of-features, local features of an image are first projected to different directions or points to generate a series of ordered bag-of-features, based on which different families of spatial bag-of-features are designed to capture the invariance of object translation, rotation, and scaling. Then the most representative features are selected based on a boosting-like method to generate a new bag-of-features-like vector representation of an image. The proposed retrieval framework works well in image retrieval task owing to the following three properties: 1) the encoding of geometric information of objects for capturing objects' spatial transformation, 2) the supervised feature selection and combination strategy for enhancing the discriminative power, and 3) the representation of bag-of-features for effective image matching and indexing for large scale image retrieval. Extensive experiments on 5000 Oxford building images and 1 million Panoramio images show the effectiveness and efficiency of the proposed features as well as the retrieval framework.
Automating remote monitoring and information therapy: An opportunity to practice telemedicine in developing countries

In industrialized countries telemedicine has proven to be a valuable tool for enabling access to knowledge and allowing information exchange, and showing that it is possible to provide good quality of healthcare to isolated communities. The modern information and communication technology provide tremendous potential for improving healthcare also in developing countries. However there are many barriers to the widespread implementation of telemedicine in rural areas of developing countries. These include deficient Internet connectivity and sophisticated peripheral medical devices. Further, to make things worse, developing countries have very high patients-per-doctor ratios. In this paper, we report our work on developing an appropriate software tool, called Health Agent, for automating telemedicine in rural areas of developing countries. It automates ordinary remote monitoring and information therapy. In the automation of remote monitoring we exploit the functionalities of SQL-triggers provided by active relational database management systems, and in automating information therapy we exploit our developed health ontology, which is specified by the modelling primitives provided by Semantic Web technologies RDF and OWL.
Phase-Plane Derived Distortion Modeling of a Fast and Accurate Digitizing Sampler

We report on continued efforts to model the distortion behavior of custom-designed digitizing samplers for accurate measurement of dynamic signals. The work is part of ongoing efforts at the National Institute of Standards and Technology (NIST) to advance the state of the art in waveform sampling metrology. In this paper, we describe an analytic error model for a sampler having a -3 dB bandwidth of 6 GHz. The model is derived from examination of the sampler's error behavior in the phase-plane. The model takes as inputs the per-sample estimates of signal amplitude, first derivative, and second derivative where the derivatives are with respect to time. The model's analytic form consists of polynomials in these terms chosen from consideration of the voltage dependence of digitizer input capacitance and previously studied error behavior in a predecessor digitizer. At 1 GHz, an improvement in total harmonic distortion from -32 dB to -46 dB is obtained when model-generated sample corrections are applied to the waveform. The effect of timebase distortion in the sampling system is also accounted for and corrected. The inclusion of second derivative dependence in the model is shown to improve the model's fit to the measured data by providing fine temporal adjustment of the fitted waveform
Poly[μ6-pyridine-2,4-dicarboxylato-barium]

In the title complex, [Ba(C7H3NO4)]n, the coordination geometry around the BaII ion can be described as a distorted bicapped trigonal-prismatic BaNO7 arrangement. The pyridine-2,4-dicarboxylic acid ligands exhibit a new coordination mode. Adjacent metal centers are linked by the O atoms of the pyridine-2,4-dicarboxylic acid ligands, and then form a three-dimensional supramolecular polymeric framework.
1-Dichloroacetyl-r-2,c-6-bis(4-methoxyphenyl)-c-3,t-3-dimethylpiperidin-4-one

In the title compound, C23H25Cl2NO4, the piperidine ring adopts a distorted boat conformation. Inversion-related molecules are linked into centrosymmetric R 2 2(16) dimers by paired C—H⋯O hydrogen bonds, and the dimers are connected via C—H⋯O hydrogen bonds into a chain running along [101].
1,4-Bis(2,2′:6′,2′′-terpyridin-4′-yl)benzene

The asymmetric unit of the title compound, C36H24N6, comprises a whole molecule. Supramolecular interactions between neighbouring molecules are essentially π–π stacking interactions with small interplanar distances [3.5140 (15) and 3.6041 (15) Å]. The central phenylene ring is tilted with respect to the two pyridine substituents, subtending angles of 36.17 (11) and 34.95 (11)°. Three of the peripheral pyridine substituents are almost coplanar with the central pyridines [dihedral angles = 5.10 (12)-8.21 (12)°], but one subtends an angle of 24.86 (12)°.