Miracle-dz/UniFAR-FTUs huggingface dataset:
PRESCRIPTION PATTERN AND USAGE OF ANTIMICROBIAL AGENTS FOR TREATING DIABETIC FOOT INFECTIONS AT TERTIARY CARE CENTRE

Objective: Due to the uncertainty about optimal antibiotic treatment, and probably substantial variation in practice, the present study was carried out to determine the bacterial profiles of infected diabetic foot ulcers (DFUs) and also to analyze the prescribing pattern of antibiotics used. Methods: A prospective observational study was carried out in the department of General surgery at a tertiary care teaching hospital, Mangalore. Demographic details and treatment data of 78 patients were collected in a specially designed Proforma, and the data were analyzed using Microsoft Excel. Results: According to Meggit-Wagner's classification, patients admitted with DFUs predominantly belonged to WAGNER 1 category (36%), followed by WAGNER 4 (26%) and WAGNER 2 (22%) categories. Out of 66 culture-positive specimens, 21 (31.8%) had monomicrobial flora, and 45 (68.2%) had polymicrobial flora. A total of 148 organisms were obtained from the specimens. The most common isolates were Staphylococcus aureus (22.3%) and Pseudomonas aeruginosa (17.5%). Ceftriaxone was the most commonly prescribed empirical antibiotic (29%), followed by linezolid (20%), piperacillin-tazobactam (20%), amoxicillin-clavulanic acid (13%), cefoperazone-sulbactam (11%). After the culture and sensitivity (C/S) results, antimicrobials were changed in 74.61% of patients in the preference of Linezolid (51%), Amikacin (27%), Levofloxacin (19%), Ciprofloxacin (17%), Piperacillin-tazobactam (13%), Cefixime (15%), Ceftriaxone (11%) among others. Clindamycin and metronidazole were used to cover anaerobic microorganisms. Conclusion: Most of the microorganisms isolated from DFUs were resistant to many types of antibiotics. Gram-positive organisms were largely sensitive to linezolid and vancomycin, while Gram-negative organisms to amikacin and imipenem. Local treatment of wounds is essential.
Blue Light Blocking Ophthalmic Lenses and Their Benefits–A Review

Light plays an important role in many functions of the human body. It improves visual acuity, contrast sensitivity and colour perception while improving mood, memory and maintaining hormonal balance through the regulation of the sleep-wake cycle. The low wavelength violet-blue light in the spectrum of 390-470 nm is high energy light and has been blamed for causing damage to the retina. Many studies have looked at how blue radiation affects eye health, visual acuity and circadian rhythm, especially in relation to the placement of filters that reduce the passage of blue light into the intraocular or ocular lens. In general, blue light improves contrast sensitivity and vision in intermediate lighting conditions, affects the sleep-wake cycle through melatonin secretion, and can cause several oxidative reactions in the retina resulting in the accumulation of photo deposits. Today it is well known that the spectrum in blue light radiation creates a wide range of health problems in every category of population, from premature infants to the elderly. This blue light spectrum is contained in the white light of Light Emitting Diode (LED) lamps, "economical" and any light source, such as that which comes from smartphones, computers, and many other devices whose light is a composition of colour spectra having the most powerful spectrum in blue. Blue blocker ophthalmic lenses provide a solution to all the above.
Organizational learning and value creation in local governance: the mediating role of crowdsourcing

Purpose Different studies have analyzed the relationship between organizational learning and value creation. However, the question of how crowdsourcing affects the relationships between organizational learning and value creation remains unexplored. This paper aims to explore the mediating role of crowdsourcing in the relationship between organizational learning and value creation in local governance. Design/methodology/approach The hypotheses were tested based on data collected from 205 local governance units in Poland using crowdsourcing. Data collection was carried out by using a set of standardized questionnaires. Correlation analyses were used to specify the strength of the relationships between the variables. To test the hypotheses, multiple regression analysis was used. Findings The results have shown that in the local governance organizational learning is related to crowdsourcing, while organizational learning is not related to value creation. Crowdsourcing does not play a mediating role in explaining the relationship between organizational learning and value creation. Research limitations/implications A research model was developed based on the relevant literature in the field of organizational learning, value creation and crowdsourcing. This study urges researchers to explore the relationship between organizational learning and value creation in other public organizations using crowdsourcing. Originality/value This is the first study on the intermediate role of crowdsourcing in the relationship between organizational learning and value creation in local governance. The proposed model enriches the existing literature and allows better understanding of how crowdsourcing acts as an intermediary in the organizational learning-value creation relationship.
Spread of COVID-19 Pandemic in Zambia: A Mathematical Model

There has been a cumulative increase in the number of COVID-19 confirmed cases, recoveries as well as deaths in Zambia as declared by the Ministry of Health on regular basis. Based on the available statistical information, this article will discuss a mathematical model concerning the spread of COVID-19 in Zambia. To predict the spread of COVID-19 in Zambian provinces, a multiple regression analysis describing the inter-play of factors influencing the increase in the number of cases is used to formalize the relationship. To ascertain the accuracy of the mathematical model used, exponential graphs regarding the spread of coronavirus (COVID-19) since its arrival over time in Zambia were obtained.
Modelling cardiac mechanical properties in three dimensions

The central problem in modelling the multi–dimensional mechanics of the heart is in identifying functional forms and parameters of the constitutive equations, which describe the material properties of the resting and active, normal and diseased myocardium. The constitutive properties of myocardium are three dimensional, anisotropic, nonlinear and time dependent. Formulating useful constitutive laws requires a combination of multi–axial tissue testing in vitro, microstructural modelling based on quantitative morphology, statistical parameter estimation, and validation with measurements from intact hearts. Recent models capture some important properties of healthy and diseased myocardium including: the nonlinear interactions between the responses to different loading patterns; the influence of the laminar myofibre sheet architecture; the effects of transverse stresses developed by the myocytes; and the relationship between collagen fibre architecture and mechanical properties in healing scar tissue after myocardial infarction.
Deuterium excess and 17O-excess variability in meteoric water across the Pacific Northwest, USA

Abstract High-precision triple oxygen isotope analysis of water has given rise to a novel second-order parameter, 17O-excess (often denoted as Δ17O), which describes the deviation from a reference relationship between δ18O and δ17O. This tracer, like deuterium excess (d-excess), is affected by kinetic fractionation (diffusion) during phase changes within the hydrologic cycle. However, unlike d-excess, 17O-excess is present in paleowater proxy minerals and is not thought to vary significantly with temperature. This makes it a promising tool in paleoclimate research, particularly in relatively arid continental regions where traditional approaches have produced equivocal results. We present new δ18O, δ17O, and δ2H data from stream waters along two east–west transects in the Pacific Northwest to explore the sensitivity of 17O-excess to topography, climate, and moisture source. We find that discrepancies in d-excess and 17O-excess between the Olympic Mountains and Coast Range are consistent with distinct moisture source meteorology, inferred from air-mass back trajectory analysis. We suggest that vapor d-excess is affected by relative humidity and temperature at its oceanic source, whereas 17O-excess vapor is controlled by relative humidity at its oceanic source. Like d-excess, 17O-excess is significantly affected by evaporation in the rain shadow of the Cascade Mountains, supporting its utility as an aridity indicator in paleoclimate studies where δ2H data are unavailable. We use a raindrop evaporation model and local meteorology to investigate the effects of subcloud evaporation on d-excess and 17O-excess along altitudinal transects. We find that subcloud evaporation explains much, but not all of observed increases in d-excess with elevation and a minor amount of 17O-excess variation in the Olympic Mountains and Coast Range of Oregon. Key Points 17O-excess correlates spatially with relative humidity across the Pacific Northwest, supporting its use as an aridity indicator in paleoclimate studies. Discrepancies in d-excess and 17O-excess between the Olympic Mountains and Oregon Coast Range suggest that their moisture source is different. Subcloud evaporation explains most of observed increases in d-excess with elevation, and a minor amount of 17O-excess variation in the Olympic Mountains and Oregon Coast Range.
COVID-19 Virus Infection and Transmission are Observably Less in Highly Dengue-Endemic Countries: Is Pre-Exposure to Dengue Virus Protective Against COVID-19 Severity and Mortality? Will the Reverse Scenario Be True?

Global severity maps of ongoing dengue epidemic and COVID-19 pandemic do not tend to overlap. Countries with high dengue endemicity (>1.5 million cases/year) are observably less hit by COVID-19 in terms of infection, transmission and mortality. Based on non-overlap of dengue and COVID-19 severity maps in general and increasing evidences of SARS-CoV-2 false-positivity in dengue antibody tests, we wonder whether regular pre-exposure to dengue virus (DENV) in highly dengue endemic countries is providing some extent of protection against COVID-19 severity. We also wondered whether immunization of susceptible populations in dengue non-endemic countries (e.g. Europe and North America) with available live-attenuated dengue vaccines, will cue the anti-viral immune response to thwart COVID-19. Risk of developing post-vaccination antibody-dependent enhancement (ADE) is low as dengue is not endemic in the aforesaid regions. Understanding the consequences of dengue and COVID-19 co-endemicity in the upcoming days is another area of huge concern. Although, it appears that dengue-induced immunity is ‘thwarting’ COVID-19, it is not clear whether conversely, COVID-19 convalescent individuals will also be resistant to future dengue attacks. On the contrary, such individuals may show higher susceptibility to DENV due to ADE caused by cross-reactive COVID-19 antibodies. The latter may bind to DENV without neutralizing the virus; instead, such antibodies may facilitate cellular entry of DENV by means of their Fcregions attached to the susceptible cells. This possibility also cautions against complications that may arise on implementing SARS-CoV-2 vaccinations in highly dengue endemic countries.
Onkonephrologie am Beispiel des Plasmazellmyeloms – Was Nephrologen und Hämatoonkologen voneinander lernen können

Abstract Plasma cell diseases, in particular multiple myeloma, represent an interdisciplinary challenge for oncologists and nephrologists. Patients often present initially with kidney problems to a nephrologist, requiring timely diagnosis and referral to an oncologist for treatment. On the other hand, a relevant part of patients will experience a – mostly temporary – decline in kidney function during the treatment course, which may require nephrological care. In any case, renal insufficiency can affect the therapeutic options. This article provides a short overview about common nephrological factors and complications which impact on the manifestation and course of treatment in patients with plasma cell diseases.
Ce que la pandémie fait à l'ingénierie pédagogique et ce que la rubrique peut en conter

La rubrique Debat-discussion s’est propose de questionner les facteurs de transformation des modeles et des pratiques de l’ingenierie ainsi que du design pedagogiques, de mettre en discussion l’importance relative de differents facteurs susceptibles d’en inflechir l’evolution. Dans un article recent, France Henri (2019) posait deux questions a l’origine de notre reflexion et du projet de la rubrique pour cette annee 2020 : « Quel changement a l’ere du numerique ? » et « Quelle ingenierie pour.
UFRS KAPSAMINDA KRİPTO PARA İŞLEMLERİNİN MUHASEBELEŞTİRİLMESİ; KRİPTO PARALAR GERÇEKTEN PARA MI?

Uluslararasi Finansal Raporlama Standartlari (UFRS) dahil hicbir muhasebe setinin kripto para islemlerine rehberlik edecek bilgi saglayamamasi ve kripto para islemlerine donuk uygulamalarin giderek artis gostermesi, kripto para islemlerinin muhasebelestirilmesini daha onemli hale getirmektedir. Bu calisma ile UFRS kapsaminda kripto paralarin ne tur bir varlik oldugu ve nasil muhasebelestirmesi gerektigi degerlendirilmistir. Yapilan degerlendirmeler dogrultusunda kripto paralari “maddi olmayan duran varlik” olarak ele almanin, getirilen elestirilere ragmen muhasebe acisindan en dogru secenek oldugu sonucuna ulasilmistir.
THE REAL-WORLD COST AND EFFECTIVENESS STUDY OF TREATING mCRC WITH BEVACIZUMAB FOLLOWED BY CETUXIMAB OR PANITUMUMAB IN WT KRAS PATIENTS

Targeted monoclonal antibodies bevacizumab, cetuximab and panitumumab are reimbursed in the Czech Republic in combination with chemotherapy or alone in metastatic colorectal cancer (mCRC). However, the high cost is a potentially limiting factor. The real-world costs and effectiveness of first line bevacizumab followed by cetuximab or panitumumab (EGFRi) were retrospectively assessed from the perspective of healthcare payer. Total 71 WT KRAS patients (56% men; median age 60.5 years) were evaluated between April 2007 and May 2017. During our follow-up period (30 months on average) 55% patients died. The mean cost to PD was EUR 32,107 and EUR 24,510 in bevacizumab and EGFRi treatment respectively with median PFS 9.7 and 5.0 months. The median overall survival was 27.2 months and the mean cost from sequential therapy initiation to death was EUR 63,682. The targeted therapy made up 77%, 86% and 76% of the costs in the first line, second line and from the initiation of sequential therapy to death respectively.
Gap Analysis of Organizational Culture and Performance in Valley View University, Ghana

value, assumption, beliefs, hope, behavior, and norms that bound the organization together. Robbins (1984) mentioned it as common perceptions which are held by the members of an organization; a system of common meaning, while George and Jones (2002) stated it as the informal design of values, norms that control the way people and groups within the organization interact with each other and with parties Abstract: Every organization has its own culture, regardless of region, country, or sector. This culture is dynamic, which is usually created within the organization. What is ideal, however, is how such cultural changes can be managed to influence a company’s performance and effectiveness, its employees’ morale, and productivity, and its ability to attract, motivate and retain talented people significantly. This is a theoretical analysis of the organizational culture and performance at Valley View University. The study employed four cultural models to analyze the existing corporate culture in the University to determine the gap. The study revealed that the external models, which are adhocracy and market cultures, best describe the cultural practices of the University, and they are less effective in the use of the internal models, which are the clan and hierarchy cultures. Nonetheless, the University appears to be interested in employee development, which is cost-driven and has relaxed in its income-increasing strategies due to the inappropriate review, monitoring, and cultural implementation. In practice, some critical decisions do not involve the employees and students. The University focuses on standards, rules, and regulations but not on efficiency. The study concludes that although the University has spent more on some changed cultures, little is earned from them, hence, the financial challenges which have resulted in the retrenchment of some employees, employee and student apathy, and the teaching out of some programs, and the eventual closure of some centers. Therefore, a change of organizational culture not well thought through and managed adequately is worth remaining unchanged.
The effect of photoperiod on development time, sex ratio and fecundity of Acanthoscelides obtectus Say (Coleoptera: Bruchidae).

Denemelerde fotoperiyodun Acanthoscelides obtectus’un ergin oncesi gelisim zamani, esey orani ve verimine etkisi incelendi. Denemeler [0A:24K, Devamli Karanlik (DK)], 6A:18K (6 saat aydinlik, 18 saat karanlik), 12A:12K (12 saat aydinlik, 12 saat karanlik), 18A:6K (18 saat aydinlik, 6 saat karanlik), 24A:0K [Devamli Aydinlik (DA)] sartlari olmak uzere bes farkli fotoperiyotta, 25±2 oC ve %60±5 nispi nemde gerceklestirilmistir. Ergin oncesi gelisim zamani en kisa DK kosullarinda tespit edilmistir. DK sartlarinda gelisim zamani 26.33±0.88 iken, DA sartlarinda 35.33±0.66 gun olmustur. Esey orani cok fazla degisiklik gostermemesine ragmen, DA sartlari erkeklerin lehine olmustur. En dusuk disi fekunditesi ise DA ve 18A:6K kosullarinda tespit edilmistir. Fekundite DK ve 6A:18K sartlarinda cok fazla farklilik gostermezken, 12A:12K, 18A:6K ve DA sartlarinda onemli bir sekilde azalmistir. Ozellikle DA ve DK birbiriyle karsilastirildiginda istatistiki olarak anlamli farklar bulunmustur.
Mineração de Opiniões com LIWC: abordagem prática sobre sistemas judiciais eletrônicos brasileiros

Opinion Mining encompasses the computational study of opinions or evaluations that people express in relation to entities, products and services. The objective of this work is to evaluate and compare opinions, published on social networks, of users of electronic judicial systems such as Projudi, e-SAJ, PJe and e-Proc. To achieve this goal, it uses the most recent Brazilian Portuguese LIWC lexicon to obtain values referring to psycholinguistic features, observing emotions and cognitive aspects present in the texts. Preliminary results indicate that the methodology adopted can bring relevant information about the users’ perception of these systems, which can be adopted in directing actions to improve them. Resumo. A Mineração de Opinião engloba o estudo computacional de opiniões ou avaliações que as pessoas expressam em relação a entidades, produtos e serviços. O objetivo deste trabalho é avaliar e comparar opiniões, publicadas em redes sociais, de usuários de sistemas de processos judiciais eletrônicos (Projudi, e-SAJ, PJe e e-Proc). Para isso, utiliza o mais recente léxico do LIWC em Português do Brasil para obter valores referentes a componentes psicolinguı́sticos, observando emoções e aspectos cognitivos presentes nos textos. Resultados preliminares indicam que a metodologia adotada pode trazer informações relevantes sobre a percepção dos usuários acerca desses sistemas, podendo ser adotada no direcionamento de ações para aperfeiçoá-los.
Impact of salinization and pollution of groundwater on the adaptation of mosquito vectors in the Jaffna peninsula, Sri Lanka

Mosquito-borne diseases are a major health concern in many tropical and sub-tropical countries. In the absence of specific treatment for many mosquito-borne diseases, vector control in the form of eliminating preimaginal development sites and insecticide application has an important role in controlling these diseases. Anthropogenic environmental changes have become important driving forces causing the adaptation of many major mosquito vectors to such changes. Anthropogenic activities are major contributors to global warming that is causing arise in sea levels. Sea level rise along with over exploitation of groundwater results in sea water intrusion to fresh water aquifers causing fresh water salinization in coastal zones. Human activities, including the extensive use of fertilizers and agrochemicals, also cause groundwater pollution. Mosquito vectors that normally lay eggs and undergo preimaginal development in fresh water are now seen to be adapting to develop in brackish and polluted water habitats. This article reviews recent findings that show the adaptation of mosquito vectors of human diseases to lay eggs and undergo preimaginal development in groundwater that is undergoing rapid salinization and pollution in the Jaffna peninsula.
Testing for correlation between two time series using a parametric bootstrap

ABSTRACT We study the problem of determining if two time series are correlated in the mean and variance. Several test statistics, originally designed for determining the correlation between two mean processes or goodness-of-fit testing, are explored and formally introduced for determining cross-correlation in variance. Simulations demonstrate the theoretical asymptotic distribution can be ineffective in finite samples. Parametric bootstrapping is shown to be an effective tool in such an enterprise. A large simulation study is provided demonstrating the efficacy of the bootstrapping method. Lastly, an empirical example explores a correlation between the Standard & Poor's 500 index and the Euro/US dollar exchange rate while also demonstrating a level of robustness for the proposed method.
An Improved Meshless Divergence-Free PBF Framework for Ocean Wave Modeling in Marine Simulator

It is a challenging work to simulate wind and waves in virtual scenes of marine simulators. In this paper, a divergence-free position based fluid (DFPBF) framework is introduced for ocean wave modeling in marine simulators. We introduce a set of constant density constraints and divergence-free velocity constraints to enforce incompressibility. By adjusting the position distribution of fluid particles, the particle density is forced to be constant. Constraining the divergence-free velocity field can keep the density change rate at zero. When correcting the position and velocity of particles, we introduced a relaxation correction scheme to accelerate the convergence of the framework. The simulation results show that as the scene scale expands and the number of fluid particles increases, this acceleration effect will be more significant. Secondly, we propose a novel particle-based three-dimensional stochastic fluctuating wind field. The Perlin noise is introduced to disturb the constant horizontal wind field to form a stochastic wind field. On this basis, a stochastic fluctuating wind field simulation framework is proposed. By adjusting the pulse period and pulse width, users can flexibly control the fluid turnover under the action of the wind field. This wind field framework can be easily integrated into the DFPBF model. Based on this wind field model, we simulated some typical wind wave scenarios, including interaction scenarios with lighthouse and lifebuoy, and verified the effectiveness of the wind field model.