Miracle-dz/UniFAR-FTUs huggingface dataset:
Diagnosis and Treatment of Perilymph Fistulas without Hearing Loss

In 1978, I reported on the diagnostic criteria and therapy based on the treatment of 34 cases of perilymph fistula. Of that group, 20 patients had no hearing loss associated with the fistula. Since that time, an additional 30 cases of fistula—15 without hearing loss—have been seen and treated operatively. The 30 significant variables of history and physical findings identified in the first study were statistically reviewed, along with a new finding that seems highly significant. Twenty-three of the 26 new cases so evaluated had a positive “eyes-closed turning test” (staggering when turning to the side of the lesion after walking with eyes closed). A further finding has been the presence of an abnormally placed round window membrane, in most cases involving the round window. The total operative population of fistulas, both those with and without hearing loss, is reviewed to identify the operative technique best suited for each window and the graft material most likely to succeed. Perichondrium is the choice tissue for graft material, except for very small fistulas at the annular ligament. The graft must be held firmly in place, with either a prosthesis or appropriate packing, carefully avoiding adhesions between the round window and the tympanic membrane.
[Usefulness of low tube operating potential (TOP) for improved detection of minimally contrast-enhanced nodules CT].

PURPOSE We recently observed that hepatic nodules which were only minimally enhanced on dynamic CT were much better visualized using a low TOP in spite of some increase of the background noise. The purpose of this study is to evaluate the potential superiority of low TOP in detecting minimally contrast-enhanced hepatic nodules on CT. METHODS AND MATERIALS A phantom was made of anger and contrast medium. Four anger columns were made four different concentrations of contrast media (0.8%, 1.0% 1.5% 1.8%). The phantom was scanned using different TOP (80, 100, 120, 140 kVp). Detectability of the columns were also evaluated contrast to noise ratio (CNR) and visually by radiologists in a doubleblind fashion. Weighted computed tomography dose index (CTDIw) was compared with different TOP. In the clinical study, seven patients were studied. The diagnostic usefulness of a TOP of 80 kVp was compared with that of 120 kVp in same patient by Dynamic CT which has better detectability of minimally contrast enhancing nodules. RESULT With using lower TOP, CNR was increased. On visual evaluation by radiologists, images taken at 80 kVp achieved the highest detectability of the columns. CTDIw associated with the 80, 100, 120, 140 kVp at one scan were 5.78 mGy, 6.64 mGy, 8.13 mGy, 11.02 mGy, respectively. In the clinical study a lesion could be detected clearly with a low TOP of 80 kVp though the existence of the lesion could not be detected at 120 kVp. The existence of the HCC was proven with DSA, CTA and CTAP. CONCLUSION It was demonstrated in the phantom study that if up-to-date equipment is used, CT operated at a TOP of 80 kVp has potentially better detectability of minimally contrast-enhanced nodules than 120 kVp.
Implementation of low interaction web server honeypot using cubieboard

Internet technology today is not free from many problems or security holes. This security holes could be exploited by an unauthorized person to steal important data. The case of the attacks occurred because the party that was attacked also did not realize the importance of network security to be applied to the system. Honeypot is a system that is designed to resemble the original production system and is made with the intention to be attacked or compromised. In this research, Cubieboard implemented using low interaction honeypot as a decoy to attract attackers. The result of this research is a low interaction honeypot implemented on embedded system with the form of Cubieboard that can emulates security vulnerabilities such as directory buster brute force, LFI, and RFI with 100% success rate, but still could not emulates SQL Injection vulnerability. One of the result of stress test with 773 samples, obtained average time of 5275 ms, deviation 2067 ms, sample throughput 367.012 per minute, and with median 5381 ms. The stress test is conducted with 50 threads and 10 ramp-ups per second.
Induction of selective inner hair cell damage by carboplatin.

Carboplatin (diammine [1,1 cyclobutane dicarboxylato (2)-0,0'] platinum) is an anti-cancer agent which can be toxic to the inner ear. We have explored the nature of this ototoxicity in the chinchilla. In this species, initial degenerative changes appear to be restricted to the inner hair cell (IHC) regions of the organ of Corti. This finding is intriguing and unusual since all other known ototoxic drugs, such as aminoglycosides, are predominantly associated with outer hair cell damage. In the present study, the mechanism of ototoxicity was investigated by comparing two different routes of carboplatin administration. Carboplatin was administered either intravenously (i.v.) or intraperitoneally (i.p.). The mode of administration influenced electrophysiological and morphological changes. Hearing thresholds were elevated in the i.v. group significantly more than in the i.p. group at all tested frequencies. The degree of hair cell damage was evaluated by scanning electron microscopy at four frequency regions in each cochlea. IHC damage in the i.v. group was significantly more severe than in the i.p. group. Carboplatin effects on a different species, the guinea pig, were also determined to clarify interspecies differences. In the guinea pig, outer hair cell damage occurred sporadically and inner hair cells remained intact. In contrast, chinchilla inner hair cells are susceptible to the ototoxic effects of carboplatin. The degree of hair cell damage appears to be dependent on the peak level of carboplatin rather than on the total dose. This animal model provides a new tool for the investigation of inner and outer hair cell function.
Modeling of Evaporation of Thin Films Using DOE

Evaporation of thin films is widely spread technology. The goal of the work has been to optimize a process of fabrication of thin resistive Ni films. Mathematical models for calculation of thickness and resistance of the films have been created. A method of design of experiments has been used for design of the models. Three types of models have been designed and tested: a linear model, a combined one and a short combined one. First the models have been verified using an F-test. It has been found that a linear model is not satisfactory, therefore it has been rejected. Subsequently remaining two models have been verified by complementary experiments, when calculated values and values measured on newly fabricated films have been compared. It has been found an excellent conformity among calculated and measured values (plusmn 3%). Then the optimum fabrication conditions have been found by optimization of the models.
Interaction between Src and a C-terminal Proline-rich Motif of Akt Is Required for Akt Activation*

Activation of Akt by growth factors is a multistep process. Here, we provide evidence that tyrosine kinase Src is directly associated with Akt through the interaction between its SH3 domain and a conserved proline-rich motif (PXXP) in the C-terminal regulatory region of Akt. Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction between Akt and the SH3 domain of Src. This possibility is corroborated by our observation that the Akt mutant lacking these two prolines fails to bind to Src both in vivo and in vitro. We also showed that phosphorylation of Tyr-315 in Akt induced by Src or EGF is dependent on the integrity of this proline-rich motif. Furthermore, the Akt mutant lacking this proline motif fails to block the transcription activity of Forkhead in 293 cells and poorly stimulates the proliferation of Madin-Darby canine kidney cells. Taken together, our data suggest that the interaction between the SH3 domain of Src family kinases and the proline-rich motif in the C-terminal regulatory region of Akt is required for tyrosine phosphorylation of Akt and its subsequent activation. It is noteworthy that this PXXP motif is conserved throughout several members of AGC kinase family, implying that association of this motif with the SH3 domain of an upstream regulator may represent a general mechanism applicable to these kinases as well.
Empirical and analytic study of stack versus heap cost for languages with closures

Abstract We present a comprehensive analysis of all the components of creation, access and disposal of heap-allocated and stack-allocated activation records. Among our results are: •Although stack frames are known to have a better cache read-miss rate than heap frames, our simple analytical model (backed up by simulation results) shows that the difference is too trivial to matter. •The cache write-miss rate of heap frames is very high; we show that a variety of miss-handling strategies (exemplified by specific modern machines) can give good performance, but not all can. •Stacks restrict the flexibility of closure representations (for higher-order functions) in important (and costly) ways. •The extra load placed on the garbage collector by heap-allocated frames is small. •The demands of modern programming languages make stacks complicated to implement efficiently and correctly. Overall, the execution cost of stack-allocated and heap-allocated frames is similar; but heap frames are simpler to implement and allow very efficient first-class continuations.
Expressions of concern and their uses

The rights and responsibilities of journal editors, when allegations of research misconduct are made, are still evolving. One of the issues that editors must consider is whether and how to communicate with their readership after notice that an allegation of research misconduct has been made about a published article. On receiving such notice, some editors have issued an ‘expression of concern’ to inform their readers of a potential problem. This article provides an analysis of the 16 expressions of concern that have been issued, how and when they were issued, and what happened next. Although this tool is relatively new, editors should consider it as part of their armament for ensuring the integrity of the research record during the sometimes lengthy period that misconduct investigations can take, and should develop policies regarding its use.
Ataxia and slurred speech after artesunate treatment for falciparum malaria.

To the Editor: Artemisinin compounds are used to treat Plasmodium falciparum infections in many countries worldwide.1,2 We describe a patient with acute cerebellar dysfunction that was temporally associated with the ingestion of artesunate. In July 1996, a 36-year-old American geologist in Ghana had fever and chills without associated neurologic symptoms. His blood smear revealed P. falciparum. He proceeded to a local market and purchased a pack of artesunate tablets manufactured in China. He took two tablets on day 1, followed by one tablet daily for the next four days. He became afebrile on day 2. A blood smear on .
A right too far? Requiring cloud service providers to deliver adequate data security to consumers

The European consumer has substantial rights when contracting for goods or services online. Nevertheless, unlike European data protection law, speciﬁc requirements for adequate data security practices are largely absent from European legislation governing Business-to-Consumer (B2C) transactions. The following article evaluates the application of current EU consumer protection requirements and appraises the extent to which they oblige service providers to include data security or information regarding data security practices in contract terms. In addition to considering the core European consumer protection instruments currently in place, the article evaluates proposed legislation for digital goods and assesses its potential application to contract terms commonly offered by cloud service providers (CSPs). Furthermore, the article provides some comparative analysis of data security requirements from the USA.
Informationelle Selbstbestimmung durch Identitätsmanagement (Informational Self-Determination by Identity Management)

Ein Identitätsmanagementsystem ermöglicht Nutzern, Art und Umfang der Herausgabe personenbezogener Daten zu kontrollieren. Damit ist es ein wichtiger Baustein für Datenschutz und mehrseitige Sicherheit. Wir beschreiben Anforderungen und Lösungen für ein umfassendes, datenschutzförderndes Identitätsmanagementsystem, das auf Pseudonymen beruht und eine mögliche Kooperation anderer Beteiligter einbezieht. Weiterhin diskutieren wir Grenzen und Risiken solcher Systeme.
Surgical treatment of atrial fibrillation using radiofrequency ablation

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Adeno-associated virus gene expression inhibits cellular transformation by heterologous genes

In this paper we report that adeno-associated virus (AAV) genomes inhibit stable transformation by several dominant selectable marker genes upon cotransfection into mouse tissue culture cells. Cotransfection of AAV genomes also inhibited the expression of pSV2cat in transient assays. In both cases, the inhibitory effect was independent of AAV DNA replication but required the AAV p5 and p19 genes, which encode proteins required for AAV DNA replication and regulation of AAV gene expression. Finally, addition of a cloned E4 gene in the transfection experiments partially blocked the AAV-mediated inhibitory activities.
Role Expectation of Nurse Managers in Geriatric Health Services Facilities

Back ground: The characteristics of geriatric health services facilities (GHSF) in Japan include provision of care focused on the life of the residents, and there is a need for cooperation between care workers and physical therapists responsible for the care. Thus, it is expected that a nurse manager occupies specific roles suited for the above characteristics that are different from those of medical facilities. Thus, we aimed to clarify the role expected of nurse managers via a questionnaire survey administered to nurses and care workers in GHSF. Methods: We used a descriptive, cross-sectional design. The study was conducted in 56 GHSF all over Japan. The instrument used for data collection was a questionnaire. The questionnaires consisted of 35 items for determining role expectation of nurse managers, the background information of respondents. The role of nurse managers was analyzed using principal factor analysis (promax rotation). Findings: A total of 259 nurses and care workers participated in this study. We extracted 34 items by factor analysis, which were classified into three factors (promotion of home nursing, management of medical care, and environment creation for collaboration and education). Among care workers, four factors consisting of 33 items were extracted. Factors one, two, and three were similar to those of nurses; “intervention to ethical problem” was extracted as the additional fourth factor. Conclusion: The roles required for nurse managers in GHSF are the promotion of home nursing, which is the original role of the health services facilities, exhibition of the specialty as a healthcare professional, creation of a work environment that promotes mutual understanding for collaboration with other professionals, and enhancement of the education and training system.
Market Mechanisms for Fair Allocation of Indivisible Objects and Money ∗

This paper studies the problem of fair allocation of indivisible objects and money among agents with quasi-linear preferences. A mechanism determines an allocation for each problem. We introduce a class of mechanisms, namely market mechanisms, which use tâtonnement process. We prove that adjustment process converges to an envy-free, efficient, and individually rational allocation. Some interesting examples of mechanisms in this class are presented.
Fever increases the risk for cardiac arrest in the Brugada syndrome.

Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva. nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.
The role of calcium in modulating the reactivity of the smooth muscle cells during ischemia/reperfusion. Part 1.

BACKGROUND Calcium ions regulate the function of cells in many ways, acting as first messengers of intercellular information and second messengers of intracellular information. Changes in cytoplasmic calcium levels depend on calcium influx from the extracellular space or calcium release from cellular stores. Increase in calcium ion concentration takes place in pathological situations, such as ischemia. In the present study the roles of calcium and G protein in contraction induced by angiotensin II (agonist of the metabotropic receptor AT1), phenylephrine (agonist of alpha1-adrenergic metabotropic receptor), and Bay K8644 (a calcium channel agonist) after ischemia/reperfusion were investigated. MATERIAL/METHODS Experiments were performed on perfused male Wistar rats' tail arteries. Contraction induced by angiotensin II, phenylephrine, and Bay K8644 mediated by intracellular or extracellular calcium after ischemia/reperfusion and in the presence of the blocker of G protein Bordetella pertussis toxin (P 7208) was analyzed. RESULTS Ischemia reduced while reperfusion augmented the response of vascular smooth muscle cells to angiotensin II and phenylephrine, but they did not change the effects of Bay K8644. P 7208 decreased the effects of phenylephrine mediated by intracellular and extracellular calcium and reduced the reactions of angiotensin II mediated only by intracellular calcium, but did not change the effects of Bay K8644. CONCLUSIONS Ischemia/reperfusion modulates vascular contraction induced by angiotensin II and phenylephrine. Both intracellular and extracellular calcium ions mediate the contraction induced by angiotensin II and phenylephrine. The results suggests that G protein modulates the effects of angiotensin II mediated by intracellular calcium ions while it plays a role in the reactions of phenylephrine mediated by calcium coming from both sources, intracellular and extracellular.
Thin-film as enabling passive integration technology for RF SoC and SiP

Thin-film Cu/BCB technology with integrated inductors, resistors and capacitors is described for the realization of high-quality on-chip and in-package Si-based passive elements. Thin-film SiP and SoC inductor and transmission line performance is compared. A SiP 7GHz power splitter, a 50GHz BPF, and two 90nm CMOS VCO operating at 5.8GHz and 15GHz with on-chip thin-film inductors are discussed.
Regulation of nif Expression in Methanococcus maripaludis

The methanogenic archaean Methanococcus maripaludis can use ammonia, alanine, or dinitrogen as a nitrogen source for growth. The euryarchaeal nitrogen repressor NrpR controls the expression of the nif (nitrogen fixation) operon, resulting in full repression with ammonia, intermediate repression with alanine, and derepression with dinitrogen. NrpR binds to two tandem operators in the nif promoter region, nifOR1 and nifOR2. Here we have undertaken both in vivo and in vitro approaches to study the way in which NrpR, nifOR1, nifOR2, and the effector 2-oxoglutarate (2OG) combine to regulate nif expression, leading to a comprehensive understanding of this archaeal regulatory system. We show that NrpR binds as a dimer to nifOR1 and cooperatively as two dimers to both operators. Cooperative binding occurs only with both operators present. nifOR1 has stronger binding and by itself can mediate the repression of nif transcription during growth on ammonia, unlike the weakly binding nifOR2. However, nifOR2 in combination with nifOR1 is critical for intermediate repression during growth on alanine. Accordingly, NrpR binds to both operators together with higher affinity than to nifOR1 alone. NrpR responds directly to 2OG, which weakens its binding to the operators. Hence, 2OG is an intracellular indicator of nitrogen deficiency and acts as an inducer of nif transcription via NrpR. This model is upheld by the recent finding (J. A. Dodsworth and J. A. Leigh, submitted for publication) in our laboratory that 2OG levels in M. maripaludis vary with growth on different nitrogen sources.
SEROLOGIC SURVEY OF INFECTIOUS DISEASES IN POPULATIONS OF MANED WOLF (CHRYSOCYON BRACHYURUS) AND CRAB-EATING FOX (CERDOCYON THOUS) FROM ÁGUAS EMENDADAS ECOLOGICAL STATION, BRAZIL

Abstract: Domestic dogs are reservoirs for many infectious diseases and may represent a potential source of infection for wild canid populations. A serologic investigation of antibodies to Toxoplasma gondii, Neospora caninum, Brucella abortus, and Leptospira spp. was conducted on three maned wolves (Chrysocyon brachyurus) and seven crab-eating foxes (Cerdocyon thous), all free-living, at the Águas Emendadas Ecological Station (ESECAE), Federal District, Brazil, between February and October 2006. Out of the 10 samples analyzed, eight (80%) were seropositive for T. gondii: 3/3 (100%) of the maned wolves and 5/7 (71.4%) of the crab-eating foxes. None of the animals presented anti–N. caninum, B. abortus, and Leptospira spp. antibodies. This study demonstrated that the wild canid populations at ESECAE presented high exposure to T. gondii and indicated that there is high environmental contamination at the Station, which can be attributed to its proximity to urban zones, the presence of domestic cats in the study area, or the existence of other wild infected felines.