Miracle-dz/UniFAR-FTUs huggingface dataset:
‘Are we losing touch?’ Mainstream parties' failure to represent their voters on immigration and its electoral consequences

Abstract In many advanced democracies, mainstream political parties have been disrupted either by the rise of new (populist) parties or by hostile takeovers. In this article we argue that immigration attitudes have had a powerful impact on the strategic environment of political parties and leaders. We show, based on evidence from a comparative study conducted by YouGov in spring of 2015, that immigration attitudes had, by that time, driven a wedge between mainstream parties – those that regularly play a role in government – and their partisans. This ‘immigration gap’ opened up enormous space for new political movements to form, either inside existing parties or outside. Furthermore, we show that the representation gap on immigration issues is a relevant predictor of vote choice, so that parties are particularly likely to lose votes when they are more distant from their supporters on immigration.
A 76-81 GHz CMOS mmW quadrature down-conversion mixer for automotive radar applications

This paper presents a mmW quadrature down-conversion mixer for 76-81 GHz automotive radar applications. A transformer-based g<boosting method and a new cascode inter-stage network are proposed to improve the gain of preamplifier. A pair of cross-coupled transistors are exploited to bleed dynamic current into mixer core to reduce noise figure while utilizing its negative resistance to improve conversion gain. Themixer is implemented in a 55-nm CMOS process and the measurement results show that the BW−33 is 5.5 GHz, the peak gain is 4.1 dB with < 0.16 dB I/Q mismatch, the input P1dB is up to -6 dBm and the minimum noise figure (NF<8=) is 19 dB while dissipating 40 mW of power. The achieved FOM is up to 0.02. key words: CMOS, mmW, Transformer-based, G<-boosting, Inter-stage network, Cross-coupled transistors, Bleed dynamic current Classification: Integrated circuits
Effect of electrostatic repulsion induced by superplasticizers on the flow behaviour of fly ash pastes

Effect of superplasticizers on fly ash pastes was evaluated by consistency tests (for lower water content pastes) and mini-slump tests (for higher water content pastes). Results indicate that only the polycarboxylate superplasticizers (PCEs) largely improved the flowability of fly ash pastes. Zeta potential measurements were conducted to explain the influence of electrostatic repulsion on flow behaviours of pastes with different superplasticizers. In fly ash pastes, Lignosulfonates (LS) and Polynaphthalene superplasticisers (PNS) depressed the zeta potential to more negative values, while the PCEs increased the zeta potential to less negative values. The more negative zeta potential represents higher electrostatic repulsion between particles. However, the workability results revealed that PCEs had better dispersing ability than PNS and LS. It was deduced that the steric hindrance may be the dominating mechanism for the better dispersing noticed with fly ash pastes, while the electrostatic repulsion may have no impact on dispersing of these pastes.
Initial treatment outcome and feasibility of low-dose cabazitaxel against docetaxel- and castration-resistant prostate cancer in a Japanese hospital

Introduction: Cabazitaxel (CBZ) is used worldwide for castration-resistant prostate cancer after docetaxel treatment. In July 2014 the drug was approved in Japan with the same induction dose used for Caucasian patients. In this study, we examined and compared the results of an initial low-dose CBZ treatment in patients admitted to our hospital. Patients and Methods: Between July 2014 and August 2018, sixteen mCRPC patients were enrolled and underwent a low-dose CBZ treatment at our hospital. We compared the results with those of a Japanese metastatic docetaxel- and castration-resistant prostate cancer Phase I study. Results: The median patient age was 77 years (range, 53–84 years). Of the 16 patients, eight (50%) had a lymph node metastasis and 11 (68.8%) had a distant metastasis, 10 of whom had only a bone metastasis. The median dose of CBZ was 30 mg (range, 20–32 mg) and the median number of CBZ cycles was 2.5 (range, 1–18). The PSA level of 9 (56.3%) patients decreased after CBZ treatment, including 4 (25%) who showed a decrease to <50%. The median time interval in which the PSA level decreased was 2 months (range, 1–18 months). The observed adverse events (AE) were neutropenia (31.3%), febrile neutropenia (6.3%), fatigue (43.8%), nausea (18.8%), diarrhea (12.5%), decreased appetite (25%), dysgeusia (6.3%), white blood cell count decrease (43.8%), platelet count decrease (12.3%), and anemia (75%). However, no patient listed an AE as the reason for discontinuing the treatment. Conclusions: Even at a low dose, CBZ could improve the PSA value in patients with CRPC previously treated with docetaxel. Dose reduction and prophylactic administration of sustained G-CSF were also safe treatment options. Further studies involving an introduction period including a modulation of duration and dose are necessary, especially in Japanese patients.
The degradation-promoting roles of deubiquitinases Ubp6 and Ubp3 in cytosolic and ER protein quality control

The quality control of intracellular proteins is achieved by degrading misfolded proteins which cannot be refolded by molecular chaperones. In eukaryotes, such degradation is handled primarily by the ubiquitin-proteasome system. However, it remains unclear whether and how protein quality control deploys various deubiquitinases. To address this question, we screened deletions or mutation of the 20 deubiquitinase genes in Saccharomyces cerevisiae and discovered that almost half of the mutations slowed the removal of misfolded proteins whereas none of the remaining mutations accelerated this process significantly. Further characterization revealed that Ubp6 maintains the level of free ubiquitin to promote the elimination of misfolded cytosolic proteins, while Ubp3 supports the degradation of misfolded cytosolic and ER luminal proteins by different mechanisms.
Impact of Dietary Fatty Acids on Macrophage Lipid Metabolism, Signaling and Function

Leukocytes are potent regulators of adipose tissue biology and whole-body metabolic homeostasis. In lean, non-obese conditions (insulin-sensitive), adipose tissue has innate and adaptive immune cells, including eosinophils, regulatory T cells, invariant NK cells, and M2 macrophages. A vast expansion in adipose tissue occurs in obesity, and this is associated with a marked alteration in the tissue leukocyte profile. There is a marked increase in B cells, CD8+ T cells, NK cells, neutrophils, and M1 macrophages. This condition induces a state of low-grade, chronic inflammation in the adipose tissue, which disrupts whole-body metabolism. Macrophages were the first leukocyte to be discovered in adipose tissue. Due to their proximity to nearby adipocytes, the macrophages are exposed to high levels of fatty acids and other lipids reported in obesity. Lipid uptake by tissue-resident macrophages is essential for their biological actions. Specifically, lipid uptake and metabolism, particularly of long-chain saturated fatty acids, activate inflammatory signaling pathways, potentiating adipose tissue inflammation, and metabolic dysfunction. Obesity exhibits increased fatty acid levels within the adipose tissue microenvironment. The increased lipid accumulation in the resident macrophages reflects the fatty acid composition of the adipocytes. The dietary fatty acid determines the fatty acid composition of the adipose tissue. Macrophages then accumulate fatty acids indirectly provided by the diet. The composition varies with the acyl chain length, e.g., short-, medium-, or long-chain, and saturated fatty acids. These fatty acids have wide-ranging effects on macrophages. We described herein in detail the impact of the different dietary fatty acids on macrophage functions. Shortly, long-chain saturated fatty acids are pro-inflammatory, whereas medium-chain fatty acids are relatively benign. Long-chain unsaturated fatty acids often antagonize the pro-inflammatory effects of long-chain saturated fatty acids.
Association between Lipid Level and Chronic Periodontitis in Productive Age at Company Clinic in Jakarta, 2019

Background: Periodontitis affects at least 72% of Indonesian community according to Indonesian Basic Health Research (Riskesdas) in 2018. Periodontitis is considered as localized inflammation. However, the condition leads to systemic change. The recognition of systemic change was observed in lipid levels by several earlier studies. This study aimed to examine the association between lipid level and chronic periodontitis and healthy periodontal status in productive age. Subjects and Method: This was a cross-sectional study conducted in a company clinic, in 2019. A total of 120 patients were selected consisting of 60 patients diagnosed with chronic periodontitis and the 60 patients with healthy periodontal status. The data of periodontitis patients were obtained from medical check-up. Data of lipid levels included total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol. The data were analyzed by a multiple linear regression. Results: Patients with chronic periodontitis showed higher LDL cholesterol (p<0.001) and triglycerides (p=0.003) than patients with normal periodontal status. Total cholesterol was higher in patients with chronic periodontitis than healthy periodontal status (p<0.001). The difference in HDL cholesterol was statistically non-significant between patients with chronic periodontitis and healthy periodontal status (p=0.963). Conclusion: Lipid level can be an indicator of periodontal disease and give more information to perform higher quality of examination. However, more studies are needed to strengthen the evidence for improving the medical check-up coverage.
In-vehicle localization based on multi-channel Bluetooth Low Energy received signal strength indicator

High-precision in-vehicle localization is the basis for both in-vehicle location-based service and the analysis of the driver or passengers’ behaviors. However, interferences like effects of multipath and reflection of the signals significantly raise great challenges to the positioning accuracy at in-vehicle environment. This article presents a novel high-precision in-vehicle localization method, namely, the LOC-in-a-Car, based on functional exploration and full use of multi-channel received signal strength indicator of Bluetooth Low Energy. To achieve higher positioning precision, a hierarchical computation algorithm based on Adaboost and support vector machine is proposed in our method. In particular, we also proposed a device calibration method to deal with the heterogeneity of different smartphone terminals. We developed an Android app as a component in which the channel time-sharing acquisition method is fulfilled, enabling smartphones to distinguish data from multi-channels. The system performance is verified via intensive experiments, of which the results show that our method can distinguish the locations of driver or passengers with an accuracy ranging from 86.80% to 92.02% for each seat on Nexus phone, and the overall accuracy is 89.86%, with standard deviation of 2.64%. On Huawei phone, the accuracy ranges from 85.43% to 93.33% with overall accuracy of 89.75% and standard deviation of 3.07%. Both outperform the existing methods.
Evaluation of biochemical changes in infected and non-infected plants of tomato with Alternaria solani

The present study was carried out to evaluate the biochemical changes occurring in infected and non infected leaves of tomato with Alternaria solani. Various biochemical constituents were studied viz., chlorophyll content (chlorophyll a and chlorophyll b), total sugars (reducing and non reducing sugar), total phenol content and total soluble protein. Results revealed that infected plants show severe necrosis and there is sudden decline in chlorophyll content (chlorophyll a and chlorophyll b) and in amount of total soluble sugar (reducing and non reducing sugar) and increase in protein and phenol content in infected plants. The result indicate that pathogen Alternaria solani causes severe alteration in biochemical constitutes of tomato plant that directly or indirectly reduce the resistance or weakens the defense response of tomato against virulent pathogen.
The Effect of Advertising and E-WoM on Brand Loyalty through Brand Image: Study on VIVO brand mobile users in Malang City

In Indonesia there are 5 smartphone brands that dominate the competition between gadget companies, namely: Samsung, Apple, Oppo, Vivo, Xiaomi. In this study I researched the VIVO brand that marketed its products massively through various advertising media and aimed to create a good brand image in the community. Ads that are spread in various media, for example: television, internet, neonbox, billboards on the streets, and so on. This research aims to find out how VIVO customers respond to VIVO's advertisements and E-WoM about their loyalty to VIVO products. Is the brand image created by VIVO through advertising and e-WoM enough to maintain customer loyalty? The results of this study are that customers respond well to positive ads and e-WoM related to VIVO products. the things that made VIVO still unable to compete were the lack of efforts to take customers from other brands to switch to VIVO. it could be because the quality is still inferior to other brands and the product choices are not too varied.
Cryptocurrency as an Investment Instrument in a Modern Financial Market

This paper considers the development of attractive strategies featuring cryptocurrency assets, considering their costs and potential risks. The object of analysis in this paper is cryptocurren- cy as an investment instrument. The main hypothesis of the research is that modern portfolio theory can be applied to cryptocurrency investments to design an investment portfolio with appropriate risk and profitability characteristics. The authors of the paper: (i) place crypto- currencies in the context of modern financial market and financial technology development; (ii) develop assessment criteria for determining attractiveness of individual cryptocurrencies; and (iii) develop recommendations for creating an optimal cryptocurrency investment portfolio. In order to test the hypothesis, the authors performed calculations and used such methods of scientific research as the collection and processing historical values for cryptocurrency rates from July 2017 to January 2018, as well as data analysis for correlation, covariance, and return on investment. It is shown that a cryptocurrency investment portfolio should be created considering investor objectives and should obey a logical relationship between risk and profitability. Therefore, cryptocurrencies should not be correlated; an investment portfolio should be sufficiently diversified to minimize risk; cryptocurrencies should be liquid, that is freely exchangeable to a fiat currency on an appropriate exchange (e.g. dollars, euros). Investors should also consider regular rebalancing of the portfolio, which could help increase its profitability.
A COMPARATIVE ANATOMICAL CHARACTERISTICS OF THE STEMS OF CLIMBING PLANTS IN ARALAM WILD LEFE SANCTUARY, KANNUR

Climbing plants differ from self-supporting plants, such as shrubs and trees, in a range of characteristics. The most notable is the mechanical properties of the stem Comparison of the differentiated anatomical structures recorded in ten species of the climbing plants. The plants selected for the present study are Ampelocissus latifolia, (Vitaceae), Lygodium flexuosum (Lygodiaceae), Centrosema virginianum (Fabaceae), Tinospora cordifolia, (Menispermaceae), Wattakakka volubilis (Asclepiadaceae) Cyclea peltata (Menispermaceae), Calycopteris floribunda (Combretaceae) Pothos scandens (Araceae) Ipomoea separia (Convolvulaceae) and Piper nigrum (Piperaceae). The stems of climbing plants are characterized by the scarcity of supporting cells (fibers) and an increase in the diameter of the xylem vessels. The study con firms that they show a greater diversity of organization than other plant life forms. This anatomical radiation could probably not exist without the achievement of a wide range of secondary growth processes. Many dicotyledons, notably those with a climbing habit, show interesting secondary structure which differs from the more usual type described, therefore, sometimes termed anomalous. The variant secondary growth is particularly widespread in tropical climbers. It is speculated that variant growth can increase stem flexibility, protect the phloem, increase storage parenchyma, aid in clinging to supports, limit physical disruption of vascular tissues during twisting and bending, and promote wound healing after girdling.
The prevalence of fear avoidance and pain catastrophising amongst patients with chronic neck pain

Background Cognitive factors impact chronic pain, but the prevalence of fear avoidance (FA) and pain catastrophising (PC) in individuals suffering from chronic neck pain (CNP) has not been investigated in South Africa. Objectives To determine the prevalence of FA and PC in patients with CNP at private physiotherapy practices in Johannesburg. Method The Tampa Scale for Kinesiophobia-11 (TSK-11) (α = 0.80) and Pain Catastrophising Scale (α = 0.87) self-report questionnaires were used in a cross-sectional study to determine the prevalence of FA and PC, respectively. Descriptive statistics and correlations using Pearson’s or Spearman’s coefficient were conducted between demographic variables and FA and PC. Non-parametric data were tested using the Wilcoxon rank-sum or Kruskal–Wallis test. Cohen’s d-value or r-value measured strength of associations. Results A sample of 106 CNP patients with a mean age of 48.7 years (± 14.8) from 25 randomly selected private practices participated in the study. Of the participants, 81% were women (n = 86). Fear avoidance and PC had a prevalence of 25.5% (n = 27) and 15.1% (n = 16), respectively. A positive correlation was found between FA-11-Total and PC-Total (r = 0.684; p = 0.0001) and between FA (TSK-11-Total and TSK-SF (somatic focus)) and PC and its subscales (r ≥ 0.602; p = 0.0001). Participants with a secondary education (26.0 ± 3.4) showed a higher FA than those with tertiary education (21.9 ± 1.5). Effect size was moderate (Cohen’s d = 0.60). Pain intensity correlated positively with both FA (Pearson’s correlation: r = 0.33; p = 0.001) and PC (Spearman’s correlation; r = 0.39; p = 0.0001). Conclusion FA and PC affect a number of patients with CNP. A lower level of education was associated with FA and a higher pain intensity was associated with higher FA and PC. Clinical implications Identifying FA and PC in patients with CNP is important to facilitate holistic management.
Students’ Grit Level as a Predictor of Their Academic Achievement in Engineering Design Courses

The primary purpose of this study is to explore the relationship between engineering students’ year of study, gender and grit level. This study also aims to assess whether there is any relationship between students’ peer assessment scores in a collaborative project-based learning course and their goal orientation — either towards performance goals or learning goals — and their grit level. The study design is a quasi-experimental design, and the methods used in this study are quantitative. Student grit level was measured using a 12-item scale. The questionnaire was administered in three engineering design courses at different levels of study. The first course is an introduction to engineering design course for firstyear engineering and computer sciences students; the second is an introduction to engineering design course for second-year engineering and computer science students; and the third is a computer-aided design/computer-aidedmanufacturing (CAD/CAM) engineering design capstone course for fourth-year mechanical engineering students. Data collection occurred during the fall semester of 2018- 2019 academic year. Students’ grit level was not found to be a predictor of students’ peer assessment scores, although their goal orientation predicted their level of contribution to their team project.
Mediating Effect of Strategic Capability on the Relationship between Knowledge Management and Non-Financial Performance: The Case of Family Firms

Drawing on the resource based view theory; an inquiry is initiated to establish the mediating effect of strategic capability on the association between knowledge management practices and non-financial performance. The study is necessitated by the gap in previous literature in which express studies on the relationship between knowledge management and non-financial performance, mediated by strategic capabilities are increasingly hard to come by. It is hypothesized that strategic capability has no mediating effect on the relationship between knowledge management and non-financial performance. To test the hypothesis, a survey of 75 family firms in Migori County, Kenya is carried out. Descriptive and inferential statistics (α = 0.05) are affected. Findings suggest that strategic capability mediate the relationship between knowledge management and non-financial performance. On the theoretical front, the study adds to the debate on strategic capabilities by showing that a firm’s valuable, rare, non-imitable, and non-substitutable resources can jumpstart an enterprise’s non-financial performance. Moreover, on the practical level, the study supports firm level activities, for instance firm productivity, core competences and marketing effectiveness.
Determinants of Job Satisfaction among High School Teachers in Kenya

The purpose of this study was to identify the determinants of job satisfaction among secondary school teachers in Murang’a South Sub-county. The objectives of the study were to: identify the determinants of job satisfaction among secondary school teachers in Murang’a South Sub-county, rank in order of importance the determinants of job satisfaction, determine satisfaction levels of secondary school teachers in Murang’a South Sub-county and come up with recommendations for improving job satisfaction. This study targeted all the 468 secondary school teachers in the 32 public secondary schools in Murang’a South Sub-county. Simple random sampling technique was employed to get a sample of 25 schools. Stratified sampling technique combined with simple random sampling technique was used to get three male and three female respondents from each school giving a sample of 150 respondents. A self-developed questionnaire was administered to the respondents who were given time to fill in the required information. The data collected was coded and then analysis done using SPSS computer software. Data analysis was done using descriptive statistics. The major determinants of satisfaction among teachers in Murang’a South Sub-county in order of importance were: pay/compensation, career progression/development, promotion opportunities, working conditions, recognition, workload, involvement in decision making and communication. Majority of the teachers in the sub-county were dissatisfied with their jobs and would not choose the teaching career if they were to start all over again. Dissatisfaction increases with age while being single affects satisfaction. The number of years a teacher spent in one job group affected job satisfaction. It is recommended that quick action be taken in addressing each of the determinants of job satisfaction with a view of increasing job satisfaction among secondary school teachers in Murang’a South Sub-county. As well, there is great need for the Teachers Service Commission to carry out job satisfaction surveys throughout the country among secondary school teachers with the aim of making the teaching profession more lucrative and attractive. Lastly, research should be carried out on the causes of increasing turnover in the teaching profession and then corrective measures taken.