Miracle-dz/UniFAR-FTUs huggingface dataset:
Kidney function decline is associated with an accelerated increase in plasma homocysteine in older adults: a longitudinal study

Abstract Few studies have been conducted to investigate the association of kidney function decline with the trajectories of homocysteine (Hcy) over time, using repeated measurements. We aimed to investigate the association of kidney function with changes in plasma Hcy levels over time. Data were collected from the Rugao Longevity and Ageing Study. In detail, plasma Hcy and creatinine levels were measured in both waves (waves 2, 3 and 4) during the 3·5-year follow-up (n 1135). Wave 2 was regarded as the baseline survey. The estimated glomerular filtration rate (eGFR) was calculated based on creatinine. Subjects were categorised into four groups according to quartiles of eGFR at baseline. Linear mixed-effect models were used to investigate the association of eGFR with subsequent plasma Hcy levels. The mean eGFR at baseline was 90·84 (sd 11·42) ml/min per 1·73 m2. The mean plasma Hcy level was 14·09 (sd 6·82) at baseline and increased to 16·28 (sd 8·27) and 17·36 (sd 10·39) μmol/l during follow-ups. In the crude model, the interaction between time and eGFR at baseline was significant (β = −0·02, 95 % CI −0·02, −0·01, P = 0·002). After adjusting for confounding factors, a significant relationship remained (β = −0·02, 95 % CI −0·02, −0·01, P = 0·003), suggesting that kidney function decline at baseline was associated with a faster increase in Hcy levels. Kidney function decline is associated with a more pronounced increase in plasma Hcy levels. Further studies with longer follow-up periods and larger sample sizes are needed to validate our findings.
Wrist extensor muscle activity is less task-dependent than wrist flexor muscle activity while simultaneously performing moderate-to-high handgrip and wrist forces

Abstract The aim of this study was to characterise wrist extensor and flexor muscle activity during combinations of moderate-to-high handgrip and wrist forces that are similar to actions and intensities used in many workplace settings. Surface electromyography was recorded from three wrist flexors and three wrist extensors while participants performed simultaneous handgrip forces and wrist forces ranging in intensities from 15% to 60% of maximum. While the wrist flexors were highly task-dependent, in that their activity significantly changed between conditions, wrist extensor activity was consistently high throughout the experiment. Wrist joint co-contraction was also significantly higher when the wrist extensors were functioning as the antagonists. These findings suggest that the wrist extensors likely demonstrate consistently higher muscleactivity during most tasks of the hand and wrist, which is likely a leading mechanism behind why they develop chronic overuse injuries more frequently than the wrist flexors. Practitioner Summary: This study was conducted to identify forearm muscle activity patterns that might help explain why the wrist extensors develop overuse injuries more frequently than the flexors. Results demonstrated that the wrist extensors are consistently, highly active during combined handgrip and wrist forces and exhibit no periods of low muscle activity. Abbreviations: BB: biceps brachii; ECR: extensor carpi radialis; ECU: extensor carpi ulnaris; ED: extensor digitorum; EMG: electromyography; ES: effect size; FCR: flexor carpi radialis; FCU: flexor carpi ulnaris; FDS: flexor digitorum superficialis; MVC: maximal voluntary contraction; MVE: maximal voluntary excitation; SD: standard deviation; SE: standard error; TB: triceps brachii
Effects of Plyometric Jump Training on Electromyographic Activity and Its Relationship to Strength and Jump Performance in Healthy Trained and Untrained Populations: A Systematic Review of Randomized Controlled Trials

Supplemental Digital Content is Available in the Text. Abstract Ramirez-Campillo, R, Garcia-Pinillos, F, Chaabene, H, Moran, J, Behm, DG, and Granacher, U. Effects of plyometric jump training on electromyographic activity and its relationship to strength and jump performance in healthy trained and untrained populations: a systematic review of randomized controlled trials. J Strength Cond Res 35(7): 2053–2065, 2021—This systematic review analyzed the effects of plyometric jump training (PJT) on muscle activation assessed with surface electromyography during the performance of strength and jumping tasks in healthy populations across the lifespan. A systematic literature search was conducted in the electronic databases PubMed/MEDLINE, Web of Science, and SCOPUS. Only randomized controlled studies were eligible to be included in this study. Our search identified 17 studies comprising 23 experimental groups and 266 subjects aged 13–73 years, which were eligible for inclusion. The included studies achieved a median Physiotherapy Evidence Database score of 6. No injuries were reported among the included studies. Significant PJT-related improvements were reported in 7 of 10 studies and in 6 of 10 studies for measures of muscle activation during the performance of strength and jumping tasks, respectively. Moreover, a secondary correlational analysis showed significant positive relationships (r = 0.86; p = 0.012; r2 = 0.74) between changes in muscle activation and changes in jump performance. However, from the total number (n = 287) of muscle activation response variables analyzed for strength and jumping tasks, ∼80% (n = 226) were reported as nonsignificant when compared with a control condition. In conclusion, PJT may improve muscle activation during the performance of strength and jumping tasks. However, conflicting results were observed probably arising from (a) studies that incorporated a large number of outcomes with reduced sensitivity to PJT, (b) methodological limitations associated to muscle activation measurement during strength and jumping tasks, and (c) limitations associated with PJT prescription. Future studies in this field should strive to solve these methodological shortcomings.
HIV infection and anaemia do not affect HbA1c for the detection of diabetes in black South Africans: Evidence from the Durban Diabetes Study

South Africa has a high burden of HIV infection and anaemia. These conditions may cause HbA1c to over‐ or underestimate glycaemia; however, this has not been comprehensively investigated in African populations. We assessed the association of anaemia, HIV infection and antiretroviral therapy (ART) with HbA1c, and implications for the detection and diagnosis of diabetes, in a black South African population.
Atrial Fibrillation And Chronic Kidney Disease.

Atrial fibrillation (AF) is the most common arrhythmia in clinical practice, with a five-fold increased stroke risk. Patients with chronic kidney disease (CKD) have a higher stroke and bleeding risk compared to the general population. The prevalence of both these conditions is increasing with our aging population, and many such patients are not anticoagulated for fear of bleeding complications. Guidelines for treatment are not yet available. In this Heartbeat, we will outline a clinical management plan for this uniquely challenging complex scenario based on a state-of-the-art publication from the June Journal of the American College of Cardiology.1
Translation and Cultural Adaptation of NIH Toolbox Cognitive Tests into Swahili and Dholuo Languages for Use in Children in Western Kenya

Abstract Objectives: Performing high-quality and reliable cognitive testing requires significant resources and training. As a result, large-scale studies involving cognitive testing are difficult to perform in low- and middle-income settings, limiting access to critical knowledge to improve academic achievement and economic production in these populations. The NIH Toolbox® is a collection of cognitive, motor, sensory, and emotional tests that can be administered and scored using an iPad® tablet, reducing the need for training and quality monitoring; and thus, it is a potential solution to this problem. Methods: We describe our process for translation and cultural adaptation of the existing NIH Toolbox tests of fluid cognition into the Swahili and Dholuo languages for use in children aged 3–14 years in western Kenya. Through serial forward and back translations, cognitive interviews, group consensus, outside feedback, and support from the NIH Toolbox team, we produced translated tests that have both face validity and linguistic validation. Results: During our cognitive interviews, we found that the five chosen tests (one each of attention, cognitive flexibility, working memory, episodic memory, and processing speed) were generally well understood by children aged 7–14 years in our chosen populations. The cognitive interviews informed alterations in translation as well as slight changes in some images to culturally adapt the tests. Conclusions: This study describes the process by which we translated five fluid cognition tests from the NIH Toolbox into the Swahili and Dholuo languages. The finished testing application will be available for future studies, including a pilot study for assessment of psychometric properties.
The influence of randomness on goals in football decreases over time. An empirical analysis of randomness involved in goal scoring in the English Premier League

ABSTRACT Performance analysis in football predominantly focuses on systematic contributions to success, thus neglecting the role of randomness. The present paper pursues a direct approach to quantify and analyse randomness in football by identifying random influences in the goal scoring process. The dataset includes all matches from the seasons 12/13 to 18/19 of the English Premier League, adding up to a total of 7,263 goals, that were checked for the occurrence of six variables of random influence. Additionally, the influence of nine situational variables was investigated. Results show that randomness was present for almost 50% of all goals. Moreover, it was demonstrated that the proportion of random goals decreased over the seven seasons (p < .001), is more pronounced for weaker teams (p < .05) as well as if the current scoreline is a draw (p < .05) and depends on the match situation (open play, freekick, corner, penalty). An improved understanding of randomness in football has important implications for both researchers and practitioners. Performance analysts should acknowledge randomness as a crucial factor to distinguish clearly between performance and success. Coaches could even consider the conscious creation of uncontrollable situations as a possible tactic to provoke random influences on goal scoring.
Uncertainty in the positioning of patients receiving treatment for brain metastases and wearing surgical mask underneath thermoplastic mask during COVID‐19 crisis

Abstract Thermoplastic masks, used along with surgical masks, enable immobilization methods to reduce the risk of infection in patients undergoing intracranial stereotactic radiosurgery and stereotactic radiotherapy (SRS/SRT) during the COVID‐19 crisis. The purpose of this study was to investigate the feasibility of thermoplastic mask immobilization with a surgical mask using an ExacTrac system. Twelve patients each with brain metastases were immobilized using a thermoplastic mask and a surgical mask and only a thermoplastic mask. Two x‐ray images were acquired to correct (XC) and verify (XV) the patient’s position at a couch angle of 0°. Subsequently, the XC and XV images were acquired at each planned couch angle for non‐coplanar beams. When the position errors were detected after couch rotation for non‐coplanar beams, the errors were corrected at each planned couch angle until a clinically acceptable tolerance was attained. The position errors in the translational and rotational directions (vertical, lateral, longitudinal, pitch, roll, and yaw) were retrospectively investigated using data from the ExacTrac system database. A standard deviation of XC translational and rotational position errors with and without a surgical mask in the lateral (1.52 vs 2.07 mm), longitudinal (1.59 vs 1.87 mm), vertical (1.00 vs 1.73 mm), pitch (0.99 vs 0.79°), roll (1.24 vs 0.68°), and yaw (1.58 vs 0.90°) directions were observed at a couch angle of 0°. Most of patient positioning errors were less than 1.0 mm or 1.0° after the couch was rotated to the planned angle for non‐coplanar beams. The overall absolute values of the translational and rotational XV position errors with and without the surgical mask were less than 0.5 mm and 0.5°, respectively. This study showed that a thermoplastic mask with a surgical mask is a feasible immobilization technique for brain SRS/SRT patients using the ExacTrac system.
Hemodynamic Forces, Endothelial Mechanotransduction, and Vascular Diseases

Cells in the tissues and organs of a living body are subjected to mechanical forces, such as pressure, friction, and tension from their surrounding environment. Cells are equipped with a mechanotransduction mechanism by which they perceive mechanical forces and transmit information into the cell interior, thereby causing physiological or pathogenetic mechano-responses. Endothelial cells (ECs) lining the inner surface of blood vessels are constantly exposed to shear stress caused by blood flow and a cyclic strain caused by intravascular pressure. A number of studies have shown that ECs are sensitive to changes in these hemodynamic forces and alter their morphology and function, sometimes by modifying gene expression. The mechanism of endothelial mechanotransduction has been elucidated, and the plasma membrane has recently been shown to act as a mechanosensor. The lipid order and cholesterol content of plasma membranes change immediately upon the exposure of ECs to hemodynamic forces, resulting in a change in membrane fluidity. These changes in a plasma membrane’s physical properties affect the conformation and function of various ion channels, receptors, and microdomains (such as caveolae and primary cilia), thereby activating a wide variety of downstream signaling pathways. Such endothelial mechanotransduction works to maintain circulatory homeostasis; however, errors in endothelial mechanotransduction can cause abnormalities in vascular physiological function, leading to the initiation and progression of various vascular diseases, such as hypertension, thrombosis, aneurysms, and atherosclerosis. Recent advances in detailed imaging technology and computational fluid dynamics analysis have enabled us to evaluate the hemodynamic forces acting on vascular tissue accurately, contributing greatly to our understanding of vascular mechanotransduction and the pathogenesis of vascular diseases, as well as the development of new therapies for vascular diseases.
Relative validity and reproducibility of a food frequency questionnaire to evaluate food group intakes among Jordanian children and adolescents.

INTRODUCTION studies of the impact of diet on the prevention and occurrence of diseases in all life stages require a reliable and valid dietary assessment tool for assessing dietary intake. OBJECTIVES this study aimed to develop and evaluate the relative validity and reproducibility of a culturally sensitive quantitative food frequency questionnaire (FFQ) to assess food group intake among Jordanian children and adolescents. METHODS the validation study was carried out on 136 children and adolescents aged between 6 and 18 years who enrolled from selected public and private schools. Fifty of these children and adolescents participated in the reproducibility phase. Food group intake from a quantitative FFQ was compared with food group intake from 24-hour dietary recalls (24h-DRs). Four 24-HRs were collected weekly for one month. RESULTS intraclass correlation coefficients between the two FFQs ranged from 0.18 for nuts to 0.98 for tea. De-attenuated and energy-adjusted correlations ranged from 0.08 for nuts to 0.95 for vegetable oils. On average, 46.6 % and 43.6 % of participants were ranked by the FFQ-1 and the 24h-DRs into the same quartile based on their crude and energy-adjusted food group intake, respectively. Bland-Altman plots showed a satisfactory agreement between the two methods for milk and milk products and vegetables. CONCLUSIONS the findings of this study suggested that the developed FFQ has excellent reproducibility and good relative validity for most food groups.
Association of the Low-density Lipoprotein Cholesterol/High-density Lipoprotein Cholesterol Ratio with Glecaprevir-pibrentasvir Treatment

Objective The change in serum lipid levels by direct-acting antiviral (DAA) treatment for chronic hepatitis C varies depending on the type of DAA. How the lipid level changes induced by glecaprevir-pibrentasvir (G/P) treatment contribute to the clinical outcome remains unclear. We conducted a prospective observational study to evaluate the effectiveness of G/P treatment and the lipid level changes. Methods The primary endpoint was a sustained virologic response at 12 weeks (SVR12). The total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels and LDL-C/HDL-C (L/H) ratio were measured every two weeks. Patients This study included 101 patients. Seventeen cases of liver cirrhosis and nine cases of DAA retreatment were registered. The G/P treatment period was 8 weeks in 74 cases and 12 weeks in 27 cases. Results SVR12 was evaluated in 96 patients. The rate of achievement of SVR12 in the evaluable cases was 100%. We found significantly elevated TC and LDL-C levels over the observation period compared to baseline. The serum levels of HDL-C did not change during treatment but were significantly increased after treatment compared to baseline. The L/H ratio was significantly increased two weeks after the start of treatment but returned to the baseline after treatment. Conclusion The primary endpoint of the SVR12 achievement rate was 100%. G/P treatment changed the serum lipid levels. Specifically, the TC and LDL-C levels increased during and after treatment, and the HDL-C levels increased after treatment. G/P treatment may be associated with a reduced thrombotic risk. Therefore, validation in large trials is recommended.
Normal Absolute Monocyte Count in Combination with Normal/High Absolute Lymphocyte Count at the Time of Relapse is Associated with Improved Survival in Patients with Early Relapsed Acute Myeloid Leukemia

Abstract This study aimed to examine the prognostic significance of peripheral absolute monocyte count (AMC) in combination with absolute lymphocyte count (ALC) at the time of relapse in a cohort of 57 patients with early relapsed (first complete remission <12 months) acute myeloid leukemia (AML). Both univariate and multivariate Cox proportional hazard regression analyses revealed that normal AMC in combination with normal/high ALC (versus low/high AMC in combination with low ALC) was significantly associated with improved OS. We concluded that the combination of AMC and ALC could be used as a prognostic marker for survival outcomes in early relapsed AML.
Specialist nursing case management support for carers of people with dementia: A qualitative study comparing experiences of carers with and without Admiral Nursing.

Carers of people with dementia can experience reduced health and well-being, but little is known about how best to support them. There is some evidence to suggest that case management may improve outcomes for carers but less evidence about the features of case management services that can effectively support carers of people with dementia. Admiral Nursing operates a case management approach staffed by specialist nurses and is the only service of its kind in the United Kingdom dedicated to helping people with dementia and their carers. This paper reports qualitative findings from a mixed methods study of Admiral Nursing. For the qualitative strand of the project, data were collected in focus groups and in-depth interviews with carers of people with dementia (n = 35) and analysed thematically using the framework approach. The aim of this analysis was to understand differences between the experiences of the carers in our sample with and without Admiral Nursing, applying Freeman's model of continuity of care (Freeman et al., Continuity of care, 2000). Participants who had received Admiral Nursing were recruited from two geographical locations and carers without experience of this service were recruited from two different areas. We found that carers in our sample felt 'supported' in circumstances where they received an ongoing service from an Admiral Nurse or other professional with expertise in dementia who was able to develop a meaningful relationship with them over time. We conclude that ongoing support, expertise in dementia and a meaningful relationship are key features of relationship continuity common in carers' reports of feeling supported. Specialist nurses are well placed to provide this continuity.
Investigating the educational experiences of transnational students: Differences in academic integration, social integration, and institutional and goal commitment.

BACKGROUND Despite the growing popularity of transnational education, there is a dearth of quantitative research regarding how transnational students experience higher education. AIMS This comparative study sought to explore differences in educational experiences between transnational and onshore domestic students enrolled either at the Australian (domestic) or Singapore (transnational) campus of an Australian university. SAMPLE AND METHODS An online survey gathered responses from 199 domestic students and 313 transnational students. RESULTS Results indicated transnational students to be significantly lower than domestic students on social and academic integration, institutional commitment, and satisfaction. No group differences were found in persistence intentions. A series of regression analyses showed integration and commitment significantly predicted student persistence intentions, across both cohorts, beyond demographic and course characteristics. CONCLUSIONS This study offers several recommendations for how universities can better foster integration and commitment in their transnational students, including better funding the development of student societies and providing realistic course previews and career advice to students upon entry into their courses. Further, universities are encouraged to reconsider their transnational staffing models to provide more opportunities for academic support and student consultation beyond the classroom.
Investigating the underlying mechanisms of the enactment effect: The role of action–object bindings in aiding immediate memory performance

Previous research has established that enacted action–object phrases lead to superior immediate memory performance compared with purely verbal memory. In the current investigation, Experiment 1 examined how enactment separately affects immediate memory for actions and objects in 24 adults by presenting action–object phrases and asking participants to recall either the actions or the objects presented in correct serial order. The results showed that when employed at presentation, enactment led to superior recall performance compared with verbal repetition, but this effect was significant only for memory for actions and not objects. Enactment during immediate recall did not lead to better memory performance compared with verbal recall for either actions or objects. To examine whether the lack of an enactment at recall was due to the splitting of action–object phrases at retrieval, Experiment 2 (n = 24) examined memory for whole action–object phrases under enactment at recall. The results showed a typical enactment at recall benefit. Furthermore, a novel binding analysis suggested that enactment recall increased the likelihood of action features being remembered in a bound pair rather than alone. Together these findings suggest that action–object bindings play a crucial role in the manifestation of the enactment effect in immediate recall, especially when enactment is employed at the recall phase.