Miracle-dz/UniFAR-FTUs huggingface dataset:
Phenotype and specificity of T cells in primary human cytomegalovirus infection during pregnancy: IL-7Rpos long-term memory phenotype is associated with protection from vertical transmission

Congenital human cytomegalovirus (HCMV) infection is the major cause of birth defects and a precise definition of the HCMV-specific T-cell response in primary infection may help define reliable correlates of immune protection during pregnancy. In this study, a high throughput method was used to define the frequency of CD4+ and CD8+ T cells specific for four HCMV proteins in the naïve compartment of seronegative subjects and the effector/memory compartments of subjects with primary/remote HCMV infection. The naïve repertoire displayed comparable frequencies of T cells that were reactive with HCMV structural (pp65, gB and the pentamer gHgLpUL128L) and non-structural (IE-1) proteins. Whereas, following natural infection, the majority of effector/memory CD4+ and CD8+ T cells recognized either gB or IE-1, respectively, and pp65. The pattern of T cell reactivity was comparable at early and late stages of infection and in pregnant women with primary HCMV infection transmitting or not transmitting the virus to the fetus. At an early stage of primary infection, about 50% of HCMV-reactive CD4+ T cells were long-term IL-7Rpos memory cells, while 6–12 months later, the frequency of these cells increased to 70%, approaching 100% in remote infections. In contrast, only 10–20% of HCMV-specific CD8+ T cells were long-term memory cells up to 12 months after infection onset, thereafter increasing to 70% in remote infections. Interestingly, a significantly higher frequency of HCMV-specific CD4+ T cells with a long-term IL-7Rpos memory phenotype was observed in non-transmitting compared to transmitting women. These findings indicate that immunodominance in HCMV infection is not predetermined in the naïve compartment, but is the result of virus-host interactions and suggest that prompt control of HCMV infection in pregnancy is associated with the rapid development of long-term IL-7Rpos memory HCMV-specific CD4+ T cells and a low risk of virus transmission to the fetus.
Multi-attribute Collaborative Filtering Recommendation

Currently researchers in the field of personalized recommendations bear little consideration on users' interest differences in resource attributes although re- source attribute is usually one of the most important factors in determining user pref- erences. To solve this problem, the paper builds an evaluation model of user interest based on resource multi-attributes, proposes a modified Pearson-Compatibility multi- attribute group decision-making algorithm, and introduces an algorithm to solve the recommendation problem of k-neighbor similar users. This study addresses the issues on preference differences of similar users, incomplete values, and advanced converge of the algorithm, and realizes multi-attribute collaborative filtering. The algorithm is proved to be effective by an experiment of collaborative recommendation among multi-users in a virtual environment. The experimental results show that the algo- rithm has a high accuracy on predicting target users' attribute preferences and has a strong anti-interference ability on deviation and incomplete values.
Contribution expérimentale à l'étude de la diffusion multiple des ultrasons en régimes de propagation linéaire et non linéaire

Ces travaux de these experimentaux portent sur la propagation lineaire et non lineaire d'ultrasons en milieux aleatoires fortement heterogenes. En regime non lineaire, nous etudions la transmission coherente d'une onde de choc a travers deux milieux aleatoires heterogenes modeles : une foret de tiges metalliques immergees dans l'eau, et un gel bulleux. L'experience montre que les effets de la non linearite et de la diffusion multiple y sont decouples. Nous exploitons alors l'etendue spectrale de l'onde de choc incidente, pour mesurer l'attenuation et la vitesse de groupe de l'onde coherente, sur un large intervalle de frequences. En comparant nos mesures a une theorie lineaire de la diffusion, incluant des correlations de paires entre centres diffuseurs, nous etendons son domaine de validite, et nous montrons par la meme qu'une onde de choc constitue un bon outil de spectroscopie des milieux fortement heterogenes. A l'aide du meme dispositif experimental, nous observons pour la premiere fois une coda ultrasonore transmise par un milieu bulleux. Dans un regime de propagation lineaire, nous exploitons la coda engendree par la diffusion multiple pour mesurer les parametres de transport des forets de tiges metalliques immergees. Nous presentons des mesures impulsionnelles et resolues en frequence de la constante de diffusion des ultrasons dans ces milieux. Ces dernieres montrent tout l'interet d'etudier la coda, qui fournit des mesures mieux resolues que l'onde coherente. Enfin, nous presentons les premieres mesures resolues en frequence de la vitesse de transport pour ces milieux modeles. Avec ces mesures, nous disposons maintenant d'un milieu heterogene synthetique parfaitement caracterise en regime lineaire.
Coupling Mechanism Analysis and Fabrication of Triaxial Gyroscopes in Monolithic MIMU

A novel fully decoupled micro inertial measurement unit (MIMU) is presented in this paper. The proposed MIMU structure, mostly focusing on the gyroscope unit, is highly symmetrical and can be limited to an area of 10,000 μm × 10,000 μm. Both the tri-axis gyroscope and tri-axis accelerometer structures are fabricated on the same single silicon chip, which can differentially detect three axes’ angular velocities and linear accelerated velocities at the same time. By elaborately arranging different decoupling beams, anchors and sensing frames, the drive and sense modes of the tri-axis gyroscope are fully decoupled from each other. Several dynamic models, including decoupling beams with fabrication imperfections, are established for theoretical analysis. The numerical simulation made by MATLAB shows the structural decoupling of three sense modes, and indicates that the key decoupling beams, which affect the quadrature error, can be improved in design. The whole fabrication process, including silicon on glass (SOG) process, dry/wet etching as well as the methods for improving the fabrication quality, is then shown. Experiments for mode frequency and quality factors of four modes (drive, yaw, pitch and roll) have been performed, and are found to be 455 (6950.2 Hz), 66 (7054.4 Hz), 109 (7034.2 Hz) and 107 (7040.5 Hz) respectively. The analysis and experiment both prove that this novel MIMU has the potential value of further intensive investigation.
Regulated Firm Strategy under Uncertainty about Regulatory Status

The effectiveness of environmental regulation is limited by the extent to which those regulations are enforced. Profit-maximizing firms will comply with a regulation if the expected net benefits of compliance are greater than the expected net benefits of noncompliance given the limited enforcement capabilities regulators have at their disposal. Analyses in the literature usually assume that firms know their regulatory status, specifically, whether specific regulatory provisions apply to them or even whether they are subject to regulation at all. But uncertainty about regulatory status is not uncommon. This paper conducts a theoretical and empirical analysis of firms’ compliance strategy when they face uncertainty about their regulatory status. Our theoretical analysis indicates that the optimal strategy for a firm with a sufficiently low probability of being subject to enforcement action will be to delay developing a protocol until warned and then delay implementation until being inspected and warned. We analyze the effect of this kind of regulatory uncertainty on the compliance protocol development component of regulations empirically within the context of the Maryland Water Quality Improvement Act (WQIA) of 1998, which requires farms meeting certain criteria to develop, file, and implement a nutrient management plan. The Maryland Department of Agriculture (MDA), which enforces this regulation, has a registry of farms that includes less than half of the farm operations in Maryland. We conduct an econometric analysis using farm level data from a University of Maryland survey combined with county-level enforcement data from MDA. Our econometric model indicates that the probability of being included in the MDA farm registry is associated with a statistically significant and economically meaningful increase in the probability of being in compliance with nutrient management regulations. Further, the probability of being in compliance is increasing in farm size while the marginal effect of being included in the MDA farm registry is decreasing in farm size; both results are consistent with the predictions of our theoretical model.
Calcium dependent action potentials produced in leech Retzius cells by tetraethylammonium chloride.

1. Retzius cells of leech segmental ganglia were exposed to tetraethylammonium chloride (TEA) presented both extracellularly, dissolved in the perfusing fluid, and intracellulary, by iontophoresis from a microelectrode. 2. Extracellular TEA, 10 and 25 mM, greatly prolonged the cells' action potentials, and the higher concentration increased their amplitude as well. At 10 mM the characteristic changes developed gradually over a period of about half an hour, while at 25 mM they appeared much more rapidly. However, at both concentrations the changes were reversible within minutes, even after long soaks in drug‐containing solution. It is therefore probable that the drug acted at the outer surface of the membrane. 3. Intracellular TEA also prolonged the action potentials but there were several differences from the response produced by extracellular application. The changes developed gradually, and for a time, each firing of the cell was a complex event consisting of several early, brief depolarizations followed by a single much larger and more prolonged one. The large, late depolarization eventually obliterated the early ones; its gradual development suggested that it was produced only after TEA diffused to some extrasomatic portion of the cell. Intracellular TEA always caused progressive depolarization; this and the changes in the action potential were both irreversible, suggesting that the site of action was on the inner surface of the membrane. 4. Manipulations of external Na and Ca provided evidence that (a) in the absence of TEA, Retzius cell action potentials were exclusively Na‐dependent, (b) that the early depolarizations in the complex action potentials produced by intracellular TEA were Na‐dependent, while the later, large depolarization was Ca‐dependent and (c) that the prolonged action potentials produced by extracellular TEA contained a large Ca‐dependent component. 5. We conclude that TEA, acting from either side of the membrane, caused a voltage‐sensitive, slowly activated Ca current to become a major contributor to the inward current of the action potential, probably by blocking the outward K current which ordinarily counteracts it. However, we cannot rule out the possibility that TEA enabled a Ca current by some means independent of its presumed action on K conductance. 6. Data resembling ours in some respects have been obtained from studies of the action of TEA on frog dorsal root ganglion cells, frog neuromuscular junction, and squid stellate ganglion. No clear counterpart of our findings has been reported form experiments on squid and amphibian axons, molluscan neurones, or frog skeletal muscle fibres.
Effectiveness of Farmers Learning on Adoption of Innovation in Organic Rice Farming of East Java

Organic rice farming system is one form of sustainable agriculture. The objective of this study was to: analyze the characteristics of organic rice farmers, analyze the level of adoption of organic rice farming innovations and analyze the effectiveness of farmers’ learning processes towards the adoption of organic rice farming innovations. The study was conducted in September 2017 until February 2018 in Bondowoso and Banyuwangi Regencies, East Java Province. The study sample was 224 people. The analysis technique used was descriptive analysis and SEM. The results of the study showed that individual characteristics of organic rice farmers include; age (middle adult), formal education (elementary), non-formal education (low), farming experience (medium), land area (narrow), cosmopolitan level (very low) and motivation level (high). Individual characteristics of farmers had a significant effect on the level of adoption of innovations in organic rice farming, particularly age, non-formal education and farming experience. The variety of learning methods of farmers was in the medium category and the learning frequency of farmers was in a very low category. The level of adoption of organic rice farming innovations was in the medium category. The learning process had effective support for the application of organic rice farming.
Marker-Based HumanMotion Capture inMultiview Sequences

This paper presents a low-cost real-time alternative to available commercial human motion capture systems. First, a set of distinguishable markers are placed on several human body landmarks, and the scene is captured by a number of calibrated and synchronized cameras. In order to establish a physical relation among markers, a human body model is defined. Markers are detected on all camera views and delivered as the input of an annealed particle filter scheme where every particle encodes an instance of the pose of the body model to be estimated. Likelihood between particles and input data is performed through the robust generalized symmetric epipolar distance and kinematic constrains are enforced in the propagation step towards avoiding impossible poses. Tests over the HumanEva annotated data set yield quantitative results showing the effectiveness of the proposed algorithm. Results over sequences involving fast and complex motions are also presented.
Study on Management of Remote Medical Follow-up Service and Analysis of Demand

Objective: The medical service organization faces the pressure of progressive market competition in the face of modern medical service,and the change of medical service mode, through strengthening the core competence of long-distance medical service, applying the scientificmanagement theory to enhance the connotation of medical service. To achieve the scientific management of medical service.Methods: Through literature search and analysis, the domestic and foreign literatures on medical follow-up service management werereviewed, and the new trends in recent years were reviewed and summarized.Results: Through the study of the management of long-distance medical follow-up service, this paper expounds the theory of medical servicerelatedtheory, and finds the breakthrough point of applying these theories to the medical follow-up service. The concept and characteristics,object, carrier, value and demand of long-distance medical follow-up service were studied in detail. This has great help to improve themanagement level of medical service agencies, which is more conducive to meeting the needs of patients' medical services and the needs ofthe public, and can better meet the needs of medical institution management and the needs of patients' disease treatment.
Platelet and Monocyte Activation in Acute Ischemic Stroke—Is There a Correlation With Stroke Etiology?

An upregulation of platelet CD40 ligand (CD40L) and CD62P has been described in atherosclerotic cardiovascular diseases and among patients with acute cerebral ischemia. Correlation between platelet and monocyte activation and the etiology of ischemic stroke were examined in 41 patients with acute ischemic stroke. Compared to 10 controls, all patients with stroke showed a significantly elevated platelet expression of CD40L (P < .001) and had significantly higher amounts of platelet–monocyte aggregates (P = .002). Plasma levels of interleukin 7 were significantly lower in patients with stroke compared to controls (P = .006). Patients with small artery disease had a significantly higher platelet CD40L expression than patients with cardioembolic stroke (P = .029). Plasma levels of soluble CD40L were significantly higher in patients with large artery disease compared to patients with cardioembolic stroke (P = .047). In conclusion, patients with acute ischemic stroke show an upregulation of platelet CD40L and an activation of cellular coagulation with highest activation in the large artery disease subgroup.
A Software Platform for Testing Intrusion Detection Systems

Intrusion detection systems monitor system activities to identify unauthorized use, misuse, or abuse. IDSs offer a defense when your system's vulnerabilities are exploited and do so without requiring you to replace expensive equipment. The steady growth in research on intrusion detection systems has created a demand for tools and methods to test their effectiveness. The authors have developed a software platform that both simulates intrusions and supports their systematic methodology for IDS testing.
Development of Reward Mechanism for Proxy Marketers Engaged in E-Commerce Platforms

A reward model/mechanism for proxy marketer-based e-commerce/e-shopping system was developed in this work. The system comprised of two modules, the shopping module which has an online shop and virtual warehouse; and the reward module. The online shop and virtual warehouse are used to manage the products on the e-commerce system, the reward mechanism is used to manage the reward paid to the proxy marketer. Proxy marketers have been introduced into online shopping to extend their market reach and increase their market share. The proxy marketers are organized in a unilevel multilevel market structure. The work offers three types of rewards: transaction reward which is paid to three generations from the proxy marketer who made the transaction; trust reward which is based on the trustworthiness rating of proxy marketer for a transaction; and turnover reward which is paid for transaction that is up to the amount stipulated for the reward. The various levels of reward were designed to total fifty percent of the profit made per transaction in order to attain sustainability of the network. The work proves that with a sustainable reward mechanism, proxy marketers can be incorporated into an e-commerce platform in a way that betters the profitability of such e-commerce platforms as compared to standalone e-shopping ones.
Potentiation by vasopressin of corticotropin release induced by corticotropin-releasing factor.

To determine whether vasopressin affects the sensitivity of the anterior pituitary to corticotropin-releasing factor, vasopressin was administered intravenously in doses subthreshold with respect to ACTH release to rats pretreated with dexamethasone (dex), Nembutal (Nem), and, sometimes, also morphine (morph). Crude ovine CRF was given intravenously immediately following the vasopressin. The adrenocortical response to CRF was increased at least 100% by the prior administration of subthreshold doses of vasopressin. When 1/20 of the intravenous dose of vasopressin was placed into both lobes of the anterior pituitary it again failed to release ACTH itself, but increased 2.5 times the response to CRF given intravenously. This potentiation of CRF-induced ACTH release by vasopressin at the adenohypophysis was not observed if the vasopressin was administered into one lobe only of the anterior pituitary. In rats pretreated with dex +Nem the potentiation was the same as in those pretreated with dex + Nem+morph. Ox.
Mecanismos inductores y vias de la apoptosis en la diarrea vírica bovina

La apoptosis es una forma de muerte celular inducida por una gran variedad de estimulos, considerada como el resultado final de una cascada en la que intervienen una serie de enzimas denominadas caspasas, inducidas tanto por estimulos externos como internos. Entre estas destacan las denominadas caspasas iniciadoras (2, 8, 9 y 10) y las caspasas ejecutoras o efectoras (3, 6 y 7). Existen dos vias principales reguladoras de la apoptosis: la via extrinseca, inducida y mediada por receptores, la cual se inicia cuando un ligando apropiado se une a receptores de muerte localizados en la superficie celular, de modo que estas uniones ligando-receptor hacen que los dominios de muerte celular intracelulares y su union a ciertas proteinas del citosol activen a las caspasas iniciadoras de esta via (pe: caspasa 8), y la via intrinseca o mitocondrial, gobernada por proteinas de la familia del Bcl-2 que agrupa un grupo de moleculas involucradas en la permeabilidad de la mitocondria, pudiendose distinguir entre moleculas anti-apoptoticas y pro-apoptoticas. El desequilibrio en la expresion de estas moleculas incrementa la permeabilidad de la membrana mitocondrial, favoreciendo la liberacion de proteinas al citosol y la activacion de las caspasas iniciadora de esta via (pe: caspasa 9). Una vez activadas las caspasas iniciadoras, estas ejerceran su actividad proteolitica sobre las denominadas caspasas efectoras o ejecutoras (3, 6 y 7), las cuales, una vez activadas ejecutaran la muerte de forma irreversible. Junto a aspectos generales relacionados con los mecanismos y vias de la apoptosis, en este trabajo se abordan aspectos relacionados con dichos mecanismos en el transcurso de la diarrea virica bovina, donde la apoptosis parece ser la responsable de la deplecion linfoide y la leucopenia que caracterizan a esta enfermedad.
Tobacco use before, at, and after first-episode psychosis: a systematic meta-analysis.

OBJECTIVE Patients with first-episode psychosis have a high prevalence of tobacco use. We aimed to examine the prevalence and course of tobacco use during early psychosis using meta-analysis. DATA SOURCES Systematic search of MEDLINE (1948-2011), Embase (1947-2011), CINAHL (1984-2011), PsycINFO (1967-2011), and ISI Web of Science (1900-2011) using the search terms [psychosis OR schizophrenia] AND [tobacco OR smoking OR nicotine]. STUDY SELECTION We located 10 studies reporting the age at initiation of daily tobacco use and the age at onset of psychosis, 31 studies reporting prevalence of tobacco use in patients with first-episode psychosis, 10 studies comparing smoking to age-/gender-matched controls, and 7 studies reporting prevalence of tobacco use at intervals after treatment. DATA EXTRACTION The following data were extracted: age at initiation of daily tobacco use and at onset of psychosis, the proportion of patients with first-episode psychosis who used tobacco, the proportion of the general population who used tobacco, and the proportion of patients with psychosis who used tobacco at various intervals after initiation of antipsychotic treatment. RESULTS The pooled estimate for the interval between initiation of tobacco use and the onset of psychosis was 5.3 years (standardized mean difference = 0.85). The estimated prevalence of tobacco users in first episode of psychosis is 58.9% (95% CI, 54.3%-63.4%). There is a strong association between first-episode psychosis and tobacco use (OR = 6.04; 95% CI, 3.03-12.02) compared with healthy controls. The prevalence of tobacco use at intervals between 6 and 120 months after treatment remained unchanged (OR = 0.996; 95% CI, 0.907-1.094). CONCLUSIONS Patients with first-episode psychosis tend to have smoked for some years prior to the onset of psychosis, have high prevalence of tobacco use at the time of presenting for treatment, and are much more likely to smoke than aged-matched controls. Their apparent difficulty in quitting has implications for tobacco cessation programs and efforts to reduce cardiovascular disease among people with mental illness.