Miracle-dz/UniFAR-FTUs huggingface dataset:
mab21l2 transgenics reveal novel expression patterns of mab21l1 and mab21l2, and conserved promoter regulation without sequence conservation

mab21l1 and mab21l2 paralogs have widespread and dynamic expression patterns during vertebrate development. Both genes are expressed in the developing eye, midbrain, neural tube, and branchial arches. Our goal was to identify promoter regions with activity in mab21l2 expression domains. Assays of mab21l2 promoter‐EGFP constructs in zebrafish embryos confirm that constructs containing 7.2 or 4.9 kb of mab21l2 promoter region are sufficient to drive expression in known (e.g., tectum, branchial arches) and unexpected domains (e.g., lens and retinal amacrine cells). A comparative analysis identifies complementary and novel expression domains of endogenous mab21l2 (e.g., lens and ventral iridocorneal canal) and mab21l1 (e.g., retinal amacrine and ganglion cells). Interestingly, therefore, despite the absence of conserved non‐coding elements, a 4.9‐kb mab21l2 promoter is sufficient to recapitulate expression in tissues unique to mab21l1 or mab21l2. Developmental Dynamics 240:745–754, 2011. © 2011 Wiley‐Liss, Inc.
Reevaluation of quantitative flow cytometric analysis for TLR2 on monocytes using F(ab′)2 fragments of monoclonal antibodies

In patients with refractory infections, reliable markers that monitor the severity and healing process are needed. The expression level of toll‐like receptor 2 (TLR2) on monocytes is such candidate. In the conventional assay system, the whole IgG (wIgG) form of anti‐TLR2 mAb has been used with control IgG, which blocks nonantigen‐specific bindings. However, the competitive reactions against Fcγ receptors (FcγRs) between labeled anti‐TLR2 mAbs and control IgG should be considered. Our goal was to precisely quantify TLR2 expression level on monocytes by flow cytometry (FCM). In this study, we prepared anti‐TLR2 mAbs, D45 (IgG2a), and D29 (IgG1), as well as their fragment antigen‐binding [F(ab′)2] fragments to avoid nonantigen‐specific binding to FcγRs. And then, we determined TLR2 expression levels on monocytes by using these mAbs/fragments and our calibration system using recombinant TLR2 beads. The binding of PE‐labeled D45 wIgG to monocytes was completely blocked with unlabeled D45 wIgG, but not with unlabeled D45 F(ab′)2 fragment. Although the nonantigen‐specific binding of D29 wIgG to nonstimulated monocytes was negligible, it was enhanced in interleukin‐10‐stimulated monocytes. It proved difficult to completely block nonantigen‐specific binding of D45 and D29 wIgGs by treatment with control IgG. It was demonstrated that the use of fluorescent‐labeled antigen‐binding region lacking the fragment crystallizable portion of anti‐TLR2 mAb [such as the PE‐labeled F(ab′)2 fragment] is indispensible for quantification of TLR2 levels on monocytes in flow cytometry. © 2010 International Society for Advancement of Cytometry
Étude de faisabilité de téléexpertise en dermatologie : à propos de 39 patients vus sur la clinique de rhumatologie

Introduction : la telemedecine est en plein essor avec des objectifs divers : ameliorer la qualite des soins, assurer une couverture sanitaire en territoire isole, repondre a une demande accrue de soins ou diminuer les couts lies aux transports. Le decret d'octobre 2010 precise les regles d'encadrement. L'objectif principal de notre travail etait d'etudier la faisabilite de la teleexpertise entre la Clinique de Dermatologie et de Rhumatologie du CHU de Grenoble localisees sur deux sites differents. L'objectif secondaire etait d'etudier la pertinence des avis donnes par teleexpertise. Materiels et methodes : il s'agit d'une etude prospective de mars a novembre 2011. Un materiel informatique et photographique a ete mis a disposition des rhumatologues et un logiciel nomme SyMU-Derm a ete cree. Resultats : 39 patients ont ete inclus et repartis en trois groupes : dermatose inflammatoire aigue, chronique et lesion tumorale. Des echanges ont ete necessaires pour 12 des 39 avis. 18 patients ont ete vus en consultation pour verifier la pertinence de la teleexpertise. Le diagnostic et la prise en charge ont ete concordants pour 9 des 18 patients. Conclusion : notre etude a confirme la faisabilite et l'interet du diagnostic par teleexpertise pour certaines pathologies dermatologiques en particulier pour les pathologies inflammatoires aigues et/ou labiles. Cette technique a ete appreciee par les medecins rhumatologues (facilite et rapidite de l'avis). Cette etude a permis de souligner l'importance de la qualite et de la disponibilite du materiel et la necessite d'une formation minimale a la Dermatologie des medecins demandeurs.
DC converter based fault analysis using simulink and RTDS

The paper aims at analyzing various DC fault detection and protection techniques. In the proposed model of a DC ship system, various AC-DC, DC-DC and DC-AC converters are used. Different converters, controlled or uncontrolled, six or twelve pulse converters are used. The paper aims at modeling and simulation of different converters in Matlab Simulink and the RTDS environment to analyze DC fault effect on the DC side and its propagation from the DC to the AC side. Comparisons are made between the simulations in the real time and Simulink environments. By comparing the results of the different converters, a strategy for developing fault identify and removal for DC shipboard distribution systems will be determined. The effect of fault resistance on fault parameters is also highlighted in the paper.
Comparison of weight changes in patients treated with different antidepressants: clinical experiences in Taiwanese patients.

BACKGROUND Psychiatric patients are more likely to gain weight when prescribed antipsychotics or antidepressants. Studies on these issues in Taiwan are scarce. This study compared weight changes in patients treated with NaSSA (Noradrenergic and Specific Serotonergic Antidepressant) and SSRIs (Selective Serotonin Reuptake Inhibitors), and investigated possible associated factors. METHODS An observational, non-randomized study was conducted on all patients diagnosed with depression attending the out-patient's clinic at a general hospital. Patients treated with NaSSA or SSRIs were monitored for 24 weeks. RESULTS Forty-Seven patients (27 patients on NaSSA and 20 on SSRIs) completed the study. Patients taking NaSSA gained an average of 1.87 kg (SD: 4.14, median: 1.0, range: -3.5 to 11.0) at the end of the study, compared to 1.83 kg (SD: 3.78; median: 1.5, range: -7.0 to 8.0) for the SSRIs group. No statistically significant difference existed between the two groups. However, patients who had never previously been treated with either SSRIs or NaSSA exhibited significantly greater weight gain (4.84 kg, SD: 3.20, median: 4.75, range: 0 to 11.0) than those who had previously been treated (-0.78 kg, SD: 2.36, median: -0.5, range: -7.0 to 3.5). Low initial body mass index and concomitant medications also seemed to be linked to weight gain. CONCLUSION Significant weight gain occurred in those patients who had not been previously treated with NaSSA or SSRIs. Patients should be informed of this possibility before initiating treatment, especially those with low body mass index and those prescribed co-medications. Furthermore, the treatment program should include weight monitoring, nutritional assessment and counseling.
Bone health and growth in glucocorticoid-treated patients with juvenile idiopathic arthritis.

OBJECTIVE To evaluate bone health and growth and their correlates in glucocorticoid (GC)-treated pediatric patients with juvenile idiopathic arthritis (JIA). METHODS Consecutive patients with a history of JIA for >or= 2 years and systemic GC treatment for >or= 3 months were assessed for bone health and its determinants. Areal bone mineral density (aBMD) and vertebral body morphology were assessed with DEXA; Z scores were adjusted for calendar and bone age. Values were correlated with biochemistry, disease activity, and medications. RESULTS Sixty-two patients (43 female; median age 11.8 yrs, median disease duration 5.6 yrs) were included. The median duration of GC treatment was 24 months and the median cumulative dose (as prednisolone) was 2.2 g. Four patients had had fractures. The median bone age-corrected aBMD Z score was -0.4 (range -2.9 to +1.8) for lumbar spine and -0.1 (range -2.1 to +2.4) for femoral neck. Abnormal vertebral morphology was observed in 6 patients (10%). No correlation was found between aBMD and disease characteristics or cumulative GC dose. The median Z score for height was +0.1 (range -2.9 to +1.5) and the median height-adjusted weight +4% (range -17% to +40%). CONCLUSION Our study showed low prevalence of osteoporosis and normal growth in children with JIA. However, asymptomatic vertebral fractures were observed in 10% of the patients, indicating that DEXA alone may not be sufficient when evaluating bone health in these children. Osteoporosis still remains a concern in children with GC-treated JIA.
Radiolocating strong ELF electromagnetic pulses using two receivers placed on different continents

In this paper we demonstrate the performance of our system in worldwide geolocation of strong ELF electromagnetic pulses. They are generated by powerful cloud-to-ground and cloud-to-ionosphere atmospheric discharges. Our system is currently composed of two broadband ELF receivers, one located in Poland and the other in the USA. Each receiver makes use of two orthogonal active magnetic antennas.
Fine tuning of the catalytic activity of colicin E7 nuclease domain by systematic N‐terminal mutations

The nuclease domain of colicin E7 (NColE7) promotes the nonspecific cleavage of nucleic acids at its C‐terminal HNH motif. Interestingly, the deletion of four N‐terminal residues (446–449 NColE7 = KRNK) resulted in complete loss of the enzyme activity. R447A mutation was reported to decrease the nuclease activity, but a detailed analysis of the role of the highly positive and flexible N‐terminus is still missing. Here, we present the study of four mutants, with a decreased activity in the following order: NColE7 >> KGNK > KGNG ∼ GGNK > GGNG. At the same time, the folding, the metal‐ion, and the DNA‐binding affinity were unaffected by the mutations as revealed by linear and circular dichroism spectroscopy, isothermal calorimetric titrations, and gel mobility shift experiments. Semiempirical quantum chemical calculations and molecular dynamics simulations revealed that K446, K449, and/or the N‐terminal amino group are able to approach the active centre in the absence of the other positively charged residues. The results suggested a complex role of the N‐terminus in the catalytic process that could be exploited in the design of a controlled nuclease.
Pneumatic dry granulation: potential to improve roller compaction technology in drug manufacture

Introduction: Solid dosage form manufacture still remains the most common in the production of pharmaceutical products. Established granulation processes can benefit from novel technical improvements, which can in turn enhance the behavior and properties of the process intermediates, that is, granules. These improvements in the manufacturing process can ultimately shorten development times, provide processing solutions for challenging materials and improve quality of drug delivery systems. Areas covered: The aim of this review is to give the reader an overview of the latest trends in research with regard to roller compaction technology. Pneumatic dry granulation is also discussed as a new development with the potential to improve and extend the use of dry granulation processes, which can result in a substantial contribution to drug delivery system development and drug product manufacture. Expert opinion: Dry granulation techniques, and more specifically roller compaction, can provide many advantages over the more established wet granulation techniques. There are still problems with roller compaction such as high amounts of fines and poor flow of granulate. Technical innovations that improve existing processes will have a considerable impact on development times and contribute to improved material processability and behavior of the end product. Pneumatic dry granulation has the potential to provide such alternatives.
Maximum efficiency formulation for inductive power transfer with multiple receivers

This paper presents closed-form expressions of optimal loads that achieve the maximum efficiency for inductive power transfer (IPT) system with multiple receivers. We model the system as a passive N-port network and jointly optimize both reactive and resistive components of the loads. The derived expression allows one to predict RF-to-RF efficiency of IPT system with any number of receivers, under any coupling condition and through any type of media.
Resultados preliminares de la adaptación al español de la Escala de Estrategias de Afrontamiento

El objetivo de esta investigacion fue estudiar si se obtienen las dimensiones sociales que postula el modelo multiaxial de afrontamiento en una muestra de poblacion hispanohablante mediante un analisis de constructo de la Escala de Estrategias de Afrontamiento, utilizada en diversos paises por su eficacia para evaluar el afrontamiento en relacion a problemas de salud. Se realizo una traduccion de la escala al espanol y se aplico a una muestra constituida por 410 estudiantes de la carrera de Psicologia. Se hizo un analisis y correccion de los reactivos para construir una version final del instrumento, que se aplico a una muestra de 309 estudiantes de una institucion de educacion superior. Con los datos de esta muestra se llevo a cabo un analisis factorial de componentes principales con rotacion varimax del que se consideraron los primeros cinco factores que explicaron 35.25% de varianza. Estos resultados indican que algunas dimensiones del MMA, como la accion agresiva-antisocial-indirecta, la evitacion, la busqueda de apoyo social, la accion asertiva y la accion instintiva se pueden evaluar mediante la version en espanol del SACS; sin embargo, deben seguirse estudiando la accion cauta y la afiliacion social, que no se observaron en esta muestra.
Pyoderma Gangrenosum, Acne and Suppurative Hidradenitis Syndrome following Bowel Bypass Surgery

The clinical triad of pyoderma gangrenosum (PG), acne and suppurative hidradenitis (PASH) has recently been described as a new disease entity within the spectrum of autoinflammatory syndromes, which are an emerging group of inflammatory diseases distinct from autoimmune, allergic and infectious disorders. PASH syndrome is similar to PAPA (pyogenic arthritis, acne and PG), but it differs in lacking the associated arthritis and on a genetic basis. PAPA syndrome is caused by mutations in a gene involved in the regulation of innate immune responses, the PSTPIP1, while no mutations have been detected to date in patients with PASH syndrome. We report a young male patient who developed coexisting disseminated PG, typical suppurative hidradenitis and acneiform eruption on the face, after he had undergone bowel bypass surgery for obesity. The cutaneous manifestations associated with bowel bypass syndrome often mimic PG or other neutrophilic dermatoses, suggesting a pathogenesis related to neutrophil-mediated inflammation for this condition. This is the first report describing PASH syndrome after bariatric surgery, and we propose to include such neutrophilic dermatoses in the list of complications occurring after bowel bypass surgery. Extensive genetic studies may help to clarify the etiopathogenesis of PASH as well as of autoinflammatory diseases in general.
Vascular Endothelium: Nature's Blood‐Compatible Container a

Vascular endothelium, the continuous, single-cell-thick lining of the cardiovascular system, constitutes Nature’s blood-compatible container. As long as blood stays within this container, it remains fluid and can perform its essential transport and communication functions unimpeded. Simple contact of blood with a nonendothelial surface, however, is sufficient to trigger platelet activation and the coagulation cascade. If unchecked, this normally adaptive hemostatic response can lead to various pathologic sequelae, including thrombosis, vascular occlusion, and ischemic tissue injury. During the last decade, our understanding of the physiologic mechanisms that normally act to maintain the integrity of the endothelial lining, as well as the pathophysiologic stimuli that can mediate its injury or dysfunction, has expanded at a rapid rate. Particularly relevant to the theme of this volume is the emerging concept of the vascular endothelium as a dynamic regulator of hemostasis and thrombosis. ’
Plan de cuidados en Enfermería del Trabajo : Caso práctico: trabajador con depresión

La depresion se constituye en uno de los diagnosticos psiquiatricos mas habituales entre la poblacion general1, con una prevalencia-ano estimada en Espana del 3,9% y una prevalencia-vida del 10,5%2,3. En su etiologia intervienen diversos factores geneticos, biologicos y psicosociales4. La depresion es una enfermedad incapacitante que altera la calidad de vida percibida y ocasiona un incremento en la utilizacion de los recursos sanitarios. Su impacto economico es importante. Algunos estudios la califican como la segunda enfermedad mental con mayores costes. Algunos estudios evidencian que los costes indirectos asociados a las perdidas de productividad laboral son mayores que los costes sanitarios directos 5-9. La incidencia de la depresion es tan relevante que la Organizacion Mundial de la Salud (OMS) estima que para el ano 2020 la depresion ocupara la segunda causa de discapacidad a nivel mundial10.
Fault tolerant insertion and verification: a case study

The particular circuit structures that allow the building of a Fault Tolerant (FT) circuit have been extensively studied in the past, but currently there is a lack of CAD support in the design and evaluation of FT circuits. The aim of the AMATISTA European project (IST project 11762) is to develop a set of tools devoted to the design of FT digital circuits. The toolset is composed of: an automatic insertion tool and a simulation tool to validate the FT design. This paper is a case study describing how this set of FTI (Fault Tolerant Insertion) and FTV (Fault Tolerant Verification) tools have been used to increase the reliability in a typical automotive application.
Un nouveau bassin néandertalien. Description morphologique des restes pelviens de Regourdou 1 (Montignac, Dordogne, France)

Lors du recolement des collections du Musee national de Prehistoire (MNP), des restes humains ont ete identifies en 2008 dans les collections de faune du site mousterien de Regourdou (Montignac). Parmi ces nouveaux vestiges, des fragments de la ceinture pelvienne sont identifies. Ils s’associent au sacrum de l’individu Regourdou 1, initialement present dans les collections de restes humains conserves au Musee d’Art et d’Archeologie du Perigord (MAAP), un jeune adulte neandertalien decrit partiellement par Piveteau (1959, 1963, 1964, 1966), Vandermeersch et Trinkaus (1995) et Maureille et al. (2001). Nous proposons ici une description morphologique du bassin de Regourdou 1, associee a une comparaison avec d’autres pelvis neandertaliens.D’une maniere generale, les os coxaux de Regourdou sont puissants, notamment au niveau des insertions musculaires. Bien que leur morphologie generale s’eloigne peu de la morphologie moderne, on observe certains traits particuliers deja decrits chez les Neandertaliens comme la deviation mediale de l’epine iliaque antero-inferieure ou la profondeur de la gouttiere sous-cotyloidienne. L’etude de ce nouveau pelvis contribue a documenter la variabilite neandertalienne d’une region anatomique toujours mal connue.
Ultrastructure of Human Umbilical Arteries: Studies on Arteries from Newborn Children Delivered by Nonsmoking, White Group D, Diabetic Mothers

The effect of diabetic metabolism on the human vascular wall was studied, using the fetal cardiovascular system at birth as an experimental model. The ultrastructure of umbilical arteries from nine newborn children of nonsmoking diabetic mothers (White group D) was compared with that of 30 healthy nonsmokers. Intimal cushions, thickening of the basement membrane often with a multilaminal appearance, and glycogen accumulations, both in the cells of the intima and the media, were found. The cells of the intima were very rich in fibrillas, identical to the underlying media myocytes. Endothelial cell death with formation of a pseudoendothelium due to migrating myocytes might be the explanation. Circ Res 47: 620-626, 1980
Magnetic resonance elastography of the transplant kidney: A feasibility study

Poster: "ECR 2014 / C-1535 / Magnetic resonance elastography of the transplant kidney: A feasibility study" by: "A. Kirpalani, N. Jiang, N. Burute, G. Leung, D. A. Yuen; Toronto, ON/CA"
Evaluating the Effect of Different Wheat Rust Disease Symptoms on Vegetation Indices Using Hyperspectral Measurements

Spectral Vegetation Indices (SVIs) have been widely used to indirectly detect plant diseases. The aim of this research is to evaluate the effect of different disease symptoms on SVIs and introduce suitable SVIs to detect rust disease. Wheat leaf rust is one of the prevalent diseases and has different symptoms including yellow, orange, dark brown, and dry areas. The reflectance spectrum data for healthy and infected leaves were collected using a spectroradiometer in the 450 to 1000 nm range. The ratio of the disease-affected area to the total leaf area and the proportion of each disease symptoms were obtained using RGB digital images. As the disease severity increases, so does the scattering of all SVI values. The indices were categorized into three groups based on their accuracies in disease detection. A few SVIs showed an accuracy of more than 60% in classification. In the first group, NBNDVI, NDVI, PRI, GI, and RVSI showed the highest amount of classification accuracy. The second and third groups showed classification accuracies of about 20% and 40% respectively. Results show that few indices have the ability to indirectly detect plant disease.
A novel efficiency optimization scalar control technique for industrial IPMSM drives

The paper deals with analysis and implementation of a new scalar control for industrial IPMSM drives which exploits an effective energy saving strategy. In particular, such a control forces the condition of maximum torque per ampere simply by assigning a polynomial relationship between the torque angle and stator current phase. In the paper a detailed study of the control strategy is provided, showing the effectiveness of the proposed method through simulations and experimental results.