Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of the Reliability and Validity of the Brazilian Version of the Here’s How I Write: A Child’s Self-Assessment and Goal Setting Tool

OBJECTIVE. Our objective was to translate the Here’s How I Write: A Child’s Self-Assessment and Goal Setting Tool (HHIW) to Portuguese; adapt it to the Brazilian culture; and analyze its reliability, validity, and clinical feasibility. METHOD. The study was developed in two steps: adaptation of the HHIW to Brazilian Portuguese, followed by experimental application to examine its validity and reliability. The participants were 60 children and their teachers, divided into two groups: Group 1, whose members had handwriting difficulties, and Group 2, whose members did not. RESULTS. Children with poor handwriting scored lower on the HHIW for both self- and teacher report. Test–retest reliability of the children’s (.96) and teachers’ (.93) questionnaires as well as internal consistency (.91 and .95, respectively) were excellent. There was good agreement (.74) between the children’s and teachers’ total scores. CONCLUSIONS. This study adds further evidence of validity and reliability and supports the international use of the HHIW. The HHIW is a useful resource to engage children and teachers in a collaborative relationship to improve handwriting.
The 2020 Mw 6.8 Elazığ (Turkey) Earthquake Reveals Rupture Behavior of the East Anatolian Fault

The 2020 Mw 6.8 Elazığ earthquake was the largest along the East Anatolian Fault (EAF) in over a century, providing valuable insights into its rupture behavior. We use satellite geodesy and seismology to detail the mainshock rupture, postseismic deformation, and aftershocks. The mainshock propagated mostly westward at ∼2 km/s from a nucleation point on an abrupt ∼10° fault bend. Only one end of the rupture corresponds to an established EAF segment boundary, and the earthquake may have propagated into the slip zone of the 1874 M ∼ 7.1 Gölcuk Gölu earthquake. It exhibits a pronounced (∼80%) shallow slip deficit, only a small proportion of which is recovered by early aseismic afterslip. The slow rupture velocity, shallow slip deficit, and minimal afterslip are characteristic of earthquakes hosted by faults of low‐to‐intermediate structural maturity, indicating that faults continue to evolve in important ways even as they accrue cumulative offsets of tens of kilometers.
Patterns and characteristics of polypharmacy among elderly residents in Danish nursing homes

Aim: To identify patterns and characteristics of polypharmacy among elderly residents in Danish nursing homes in the Northern region of Denmark. Materials & methods: Twenty-five nursing homes were contacted, where each supplied 20 randomly selected anonymized residents’ information. Residents were 65 years or older, concurrently taking five or more medications. Drug–drug interactions and potential adverse effects were investigated. Results: One hundred residents (68% females; 32% males) were included. The most prevalent co-morbid condition was cardiovascular disease, and the most prevalent medications were for gastrointestinal- and metabolism-related conditions. Age influenced the number of drugs (p = 0.013) and drug–drug interactions per resident (p = 0.039), with a positive correlation. Conclusion: Elderly residents of the studied nursing homes were potentially affected by an inappropriate polypharmacy.
Creating Personas on Which to Build Services for Latinx Users: A Proof of Concept

ABSTRACT The current article presents a proof of concept wherein personas were created that could support library services and collections for Latinx community members in the Midwestern United States. Personas are first described and their use in the library literature is explored. The reproducible method employed in creating the personas is then presented in detail, followed by a short discussion of the results of the persona creation. Next, a high-level discussion of the project is presented, as well as reflections on how librarians can adapt this process in efforts to design products and services to meet the needs of specific groups.
CEMP-1 Levels in Periodontal Wound Fluid during the Early Phase of Healing: Prospective Clinical Trial

Objectives Cementogenesis seems to be significantly compromised during tissue inflammation. In dental practice, surgical procedures are performed with the aim to regenerate periodontium including cementum. However, inflammation that occurs during the initial healing phases after surgery may impair regeneration of this tissues. The aim of the present study was to assess if surgical procedures designed to regenerate periodontium might affect levels of cementum protein-1 (CEMP-1) in periodontal wound fluid during early phase of healing. Materials and Methods In 36 patients, 18 intrabony periodontal defects were treated with regenerative therapy (REG group) and 18 suprabony periodontal defects were treated with open flap debridement (OFD group). In the experimental sites, gingival crevicular fluid was collected immediately before surgery, and periodontal wound fluid was collected 4, 7, 14, and 21 days after surgery. CEMP-1 levels were detected by indirect enzyme-linked immunosorbent assay technique. Results At the analysis, it resulted that there was a significant average difference in CEMP-1 values between the REG and OFD groups at baseline (p = 0.041), the CEMP-1-modeled average in the OFD group was lower by 0.45 ng/ml. There was a significant trend in CEMP-1 over time, and this trend was different among the 2 groups: the REG group showed a statistically significant rising CEMP-1 trend (0.18 ng/ml a week p = 0.012), while the OFD had a trend that was significantly lower (-0.22 ng/ml a week compared to the REG group trend p = 0.023), the OFD group lost on average 0.05 ng/ml a week. In REG sites, GCF protein levels resulted also related to clinical parameters. Conclusions During the initial inflammatory phase of periodontal healing, CEMP-1 levels decrease regardless of the surgical protocol applied. The surgical procedures used to regenerate periodontal tissue are able to reverse this trend and to induce significant increase of CEMP-1 in periodontal wound fluid after the first week postop.
Racial Bias: A Buried Cornerstone of the Administrative State

Historians of American public administration have largely perpetuated its self-image of neutrality and scientific detachment. Yet public agencies are shaped by their political and cultural environments. Long-standing myths and historical narratives about the meaning of America reveal not neutrality but racial bias dating back centuries, a pattern sustained, in part, by failure to recognize its existence. This article explores how historical understandings of the administrative state have neglected the influence of racial bias on the development of administrative practices. We suggest that a reconstructed understanding may strengthen support for anti-racism efforts, such as diversity training, representative bureaucracy, and social equity.
Mycobacterium tuberculosis infection of host cells in space and time

ABSTRACT Tuberculosis (TB) caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb) remains one of the deadliest infectious diseases with over a billion deaths in the past 200 years (Paulson 2013). TB causes more deaths worldwide than any other single infectious agent, with 10.4 million new cases and close to 1.7 million deaths in 2017. The obstacles that make TB hard to treat and eradicate are intrinsically linked to the intracellular lifestyle of Mtb. Mtb needs to replicate within human cells to disseminate to other individuals and cause disease. However, we still do not completely understand how Mtb manages to survive within eukaryotic cells and why some cells are able to eradicate this lethal pathogen. Here, we summarise the current knowledge of the complex host cell-pathogen interactions in TB and review the cellular mechanisms operating at the interface between Mtb and the human host cell, highlighting the technical and methodological challenges to investigating the cell biology of human host cell-Mtb interactions.
Aboveground tree growth is a minor and decoupled fraction of boreal forest carbon input

<p>The boreal biome accounts for approximately one third of the terrestrial carbon (C) sink. However, estimates of its individual C pools remain uncertain and are often limited to specific points in time. Here, focusing on the southern edge of the boreal forest in central Canada, we quantified the magnitude and temporal dynamics of C allocation to aboveground tree growth at a mature black spruce (<em>Picea mariana</em>)-dominated forest stand in Saskatchewan. We reconstructed annual total live aboveground tree biomass increment (AGBi) using a biometric approach, i.e., species-specific allometry combined with forest stand characteristics and tree ring widths collected with a C-oriented sampling design. We explored the links between boreal tree growth and ecosystem C input by comparing AGBi with eddy-covariance-derived ecosystem C fluxes from 1999 to 2015. Mean AGBi at the study site was 71 &#177; 7 g C m<sup>&#8211;2 </sup>(1999&#8211;2015), which is only a minor fraction of gross ecosystem production (GEP; i.e., AGBi / GEP &#8776; 9 %). Ecosystem C input and AGBi were decoupled, highlighting the potential role of direct sink limitations (temperature, water availability) on boreal tree wood formation. Moreover, C allocation to AGBi remained stable over time, with a temporal trend of near zero (&#8211;0.0001 yr<sup>&#8211;1</sup>; p-value=0.775), contrary to significant trends in GEP (+5.72 g C m<sup>&#8211;2</sup> yr<sup>&#8211;2</sup>; p-value=0.02) and ecosystem C use efficiency (i.e., NPP / GEP; &#8211;0.0041 yr<sup>&#8211;1</sup>, p-value=0.007). These findings highlight the importance of belowground tree C investments, together with the substantial contribution of understory, ground cover and soil to the boreal forest C balance. Our quantitative insights into the magnitude and temporal dynamics of aboveground boreal tree C allocation offer additional observational constraints for terrestrial ecosystem models that, to date, are biased in converting C input to biomass, and can guide forest-management strategies for mitigating carbon dioxide emissions. </p>
Detección de plagio translingüe con grafos semánticos: experimentando con recursos en abierto

Hoy en dia el idioma ha dejado de ser una barrera para plagiar documentos disponibles en Internet. Tras enfoques probabilisticos ya clasicos que no alcanzan buenos resultados con documentos multilingues con parafrasis (Barron-Cedeno, 2012), aparecen trabajos que, utilizando grafos de conocimiento, aumentan la capacidad semantica del analisis de las oraciones y mejoran los resultados de deteccion de plagio. Ademas, actualmente hay recursos linguisticos, basados en el conocimiento, o de desarrollo de software que estan disponibles para la experimentacion, una vez decidido cual de ellos elegir, cuales estan realmente disponibles en abierto, que eficiencia aportan si se integran en la experimentacion planteada, o que tipo de caracteristicas debe tener el ordenador o el servidor necesario para la investigacion. Este trabajo plantea una investigacion experimental para la deteccion de plagio translingue siguiendo una linea de investigacion y utilizando recursos disponibles en abierto. Los resultados alcanzan el estado del arte, y esperamos que el planteamiento seguido, el analisis justificado y las dificultades tecnicas reportadas, acercara a los lectores la metodologia necesaria en este tipo de experimentaciones y permitira planificar sus trabajos futuros. El software desarrollado esta disponible en abierto.
Evaluation of the efficacy and safety of injectable glycosaminoglycan-peptide complex (GPC) in patients with osteoarthritis: a multicenter observational study GLADIOLUS (GPC in the treatment of osteoarthritis: a follow-up study of pain relief and local symptom reduction)

Glycosaminoglycan-peptide complex (GPC) is a popular injectable extended-release symptomatic agent (ERSA) in Russia for the treatment of osteoarthritis (OA). To date, no large-scale studies of GPC used in real clinical practice have been conducted in our country.Objective: to evaluate the efficacy and safety of GPC in the treatment of OA in real clinical practice.Patients and methods. A multicenter observational non-interventional study was performed to evaluate the efficacy of GPC (Rumalon® , a cycle of intramuscular injections thrice weekly; a total of 25 injections). A study group consisted of 2,955 patients (75.4% female) aged 61.4±11.8 years) with knee and hip OA, and generalized OA (GOA) with the previous inefficacy of oral ERSAs, moderate/severe pain, and the need for regular use of nonsteroidal anti-inflammatory drugs (NSAIDs). 414 (14%) patients received a GPC and diacerein combination 100 mg/day. The investigators assessed the dynamics of pain during movement and at rest, functional disorders (on a numeric rating scale (NRS) of 0–10), as well as the need for NSAIDs at 12 weeks after starting the GPC cycle.Results and discussion. 98.5% of the patients completed their GPC treatment cycle. The therapy decreased the intensity of pain at rest from 4 [3; 5] to 1 [0; 2] and during movement from 6 [5; 7] to 2 [1; 3] and reduced the severity of functional disorders from 5 [4; 6] to 1 [0; 3]. The number of patients with a good response to therapy (a≥50% decrease in symptom severity) for pain at rest and during movement was 55.6 and 53.5%, respectively; and for functional disorders was 50.8%. 68.1% of patients stopped taking NSAIDs. The GPC and diacerein combination was more effective than GPC monotherapy: the number of patients with a ≥50% decrease in movement pain was 62.8 and 54.3%, respectively (p <0.001). GPC was well tolerated. During treatment, there were skin allergic reactions (0.3%), moderate injection-site pain (0.37%), and adverse reactions (ARs) related to the gastrointestinal tract (8%) and cardiovascular system (6%) (which were likely to be caused by NSAIDs). There were no serious ARs that were life-threatening and required hospitalization.Conclusion. GPC allows successful control of the main symptoms of knee and hip OA and GOA, by reducing pain, and those of functional disorders, and the need for NSAIDs. The GPC and diacerein combination is more effective than GPC monotherapy. GPC therapy is well tolerated and very rarely causes ARs.
An LSTM-Based Method Considering History and Real-Time Data for Passenger Flow Prediction

With the development of big data and deep learning, bus passenger flow prediction considering real-time data becomes possible. Real-time traffic flow prediction helps to grasp real-time passenger flow dynamics, provide early warning for a sudden passenger flow and data support for real-time bus plan changes, and improve the stability of urban transportation systems. To solve the problem of passenger flow prediction considering real-time data, this paper proposes a novel passenger flow prediction network model based on long short-term memory (LSTM) networks. The model includes four parts: feature extraction based on Xgboost model, information coding based on historical data, information coding based on real-time data, and decoding based on a multi-layer neural network. In the feature extraction part, the data dimension is increased by fusing bus data and points of interest to improve the number of parameters and model accuracy. In the historical information coding part, we use the date as the index in the LSTM structure to encode historical data and provide relevant information for prediction; in the real-time data coding part, the daily half-hour time interval is used as the index to encode real-time data and provide real-time prediction information; in the decoding part, the passenger flow data for the next two 30 min interval outputs by decoding all the information. To our best knowledge, it is the first time to real-time information has been taken into consideration in passenger flow prediction based on LSTM. The proposed model can achieve better accuracy compared to the LSTM and other baseline methods.
Document Reordering for Faster Intersection

A lot of research has studied how to optimize inverted index structures in search engines through suitable reassignment of document identifiers. This approach was originally proposed to allow for better compression of the index, but subsequent work showed that it can also result in significant speed-ups for conjunctive queries and even certain types of disjunctive top-k algorithms. However, we do not have a good understanding of why this happens, and how we could directly optimize an index for query processing speed. As a result, existing techniques attempt to optimize for size, and treat speed increases as a welcome side-effect. In this paper, we take an initial but important step towards understanding and modeling speed increases due to document reordering. We define the problem of minimizing the cost of queries given an inverted index and a query distribution, relate it to work on adaptive set intersection, and show that it is fundamentally different from that of minimizing compressed index size. We then propose a heuristic algorithm for finding a document reordering that minimizes query processing costs under suitable cost models. Our experiments show significant increases in the speed of intersections over state-of-the-art reordering techniques.
On the Maximization of Joint Velocities and Generalized Reactions in the Workspace and Singularity Analysis of Parallel Mechanisms

Summary An approach for calculating the maximum possible absolute values of joint velocities or generalized reactions in a leg of a parallel mechanism has been considered in this paper. The Jacobian analysis and the Screw theory-based methods have been used to acquire the result. These values are calculated for the “worst” directions of the external load or end-effector’s velocity for each leg. The feasibility of using these parameters as the measures of closeness to different types of parallel mechanism singularity is discussed. Further, how this approach is related to the state-of-the-art methods has been illustrated. The key aspect of the discussed approach is that the normalization of vectors or screws is carried out separately for angular and linear components. One possible advantage of such an approach is that it deals only with the kinematic and statics of the mechanism while still providing physically meaningful and practically applicable measures. Case studies of a 3-Degrees Of Freedom translational parallel mechanism and a planar parallel mechanism are presented for illustration and comparison.
Stationarity preserving schemes for multi-dimensional linear systems

There is a qualitative difference between one-dimensional and multi-dimensional solutions to the Euler equations: new features that arise are vorticity and a nontrivial incompressible (low Mach number) limit. They present challenges to finite volume methods. It seems that an important step in this direction is to first study the new features for the multi-dimensional acoustic equations. There exists an analogue of the low Mach number limit for this system and its vorticity is stationary. It is shown that a scheme that possesses a stationary discrete vorticity (vorticity preserving) also has stationary states that are discretizations of all the analytic stationary states. This property is termed stationarity preserving. Both these features are not generically fulfilled by finite volume schemes; in this paper a condition is derived that determines whether a scheme is stationarity preserving (or, equivalently, vorticity preserving) on a Cartesian grid. Additionally, this paper also uncovers a previously unknown connection to schemes that comply with the low Mach number limit. Truly multi-dimensional schemes are found to arise naturally and it is shown that a multi-dimensional discrete divergence previously discussed in the literature is the only possible stationarity preserving one (in a certain class).
GSK 3 β and CREB 3 Gene Expression Profiling in Benign and Malignant Salivary Gland Tumors

Background: Salivary gland tumors (SGT) are rare lesions with uncertain histopathology. One of the major signaling pathways that participate in the development of several tumors is protein kinase A. In this pathway, glycogen synthase kinase β (GSK3β) and cAMP responsive element binding protein (CREB3) are two genes which are supposed to be down regulated in most human tumors. The expression level of the genes was evaluated in SGT to scrutinize their possible under expression in these tumors. Methods: Forty eight fresh tissue samples were obtained from patients with benign and malignant SGT, including pleomorphic adenoma, warthin’s tumor, mucoepidermoid carcinoma (MEC), salivary duct carcinoma and carcinoma ex pleomorphic adenoma. Eight normal samples were used as controls. Quantitative real-time PCR was used to analyze the expression level of interest genes. Results: Data was analyzed by statistical methods. GSK3β was downregulate in all samples and all results were statistically significant (P<0.05). CREB3 did not show a significant decrease or increase in its mRNA expression, but the results were significant in MEC and salivary duct carcinoma. Conclusion: GSK3β down regulation has been reported in many human tumors. This gene stimulates CREB3, inducing cell proliferation and oncogenesis. Our findings showed GSK3β down regulation; however, CREB3 expression level was close to normal group. No association between CREB3 expression and inactivated GSK3β could be postulated in SGT. Iran. Biomed. J. 16 (3): 140-144, 2012
Tectonic terranes underlying the present-day Caribbean plate: their tectonic origin, sedimentary thickness, subsidence histories and regional controls on hydrocarbon resources

Abstract Thick sedimentary cover (≤16 km), vintage seismic and disparate crustal terranes have hindered understanding of the basement underlying the Caribbean plate. The plate formed by Early Cretaceous to Miocene amalgamation of four crustal types: the Caribbean Large Igneous Province oceanic plateau; the Chortis continental block; the related Great Arc of the Caribbean and Siuna/Mesquito Composite Oceanic Terranes island arc blocks; and the Colombian and Venezuelan basin oceanic crust. We characterize each terrane through interpretation of surface geology, 62 000-line-km of 2D seismic reflection data, 366 seismic refraction stations, 47 wells, 74 basement samples, 2D forward modelling, magnetic and gravity anomaly grids, and integration of previous studies. Basins overlying island arc crust are small, fault-bounded and deep, while on continental crust, they are broader and shallower. Strongly flexed oceanic and oceanic plateau crust along amagmatic subduction zones on the southern and northeastern edges of the Caribbean plate produce the largest and deepest sediment-filled basins. Areas of proven hydrocarbon source rocks and mapped seeps are associated with continental and island arc terranes in the western Caribbean plate, while organically-rich, but immature, Late Cretaceous source rocks occur across the more elevated areas of the central and eastern Caribbean plate interior.