Miracle-dz/UniFAR-FTUs huggingface dataset:
The Factor VII-Platelet Interplay: Effectiveness of Recombinant Factor VIIa in the Treatment of Bleeding in Severe Thrombocytopathia

Recently, high-dose factor VIIa has been used to correct bleeding in patients with various thrombocytopathias including Glanzmann's thrombasthenia, Bernard-Soulier syndrome, and uremia. High-dose factor VIIa is postulated to act on platelets in the absence of tissue factor to activate factors IX and X and thus enhance thrombin generation. This enhanced thrombin generation might help provide hemostasis in patients with thrombocytopathias through several mechanisms. Enhanced thrombin generation would provide a strong signal for recruitment of other platelets. Also, enhanced fibrin deposition might provide mechanisms for bypassing the specific defect in thrombocytopathias. Thus, platelets from a patient with Bernard-Soulier syndrome might associate with fibrin by a glycoprotein IIb-IIIa-mediated mechanism. Also, platelets from a patient with Glanzmann's thrombasthenia might associate with fibrin through von Willebrand factor-mediated interactions with glycoprotein Ib-V-IX. Finally, enhanced thrombin generation on platelets would mean that fewer platelets are required for hemostasis.
A Murine Model of Renal Abscess Formation

ABSTRACT We developed a murine model of kidney abscess by direct renal injection of either Escherichia coli (1 × 106 to 7 × 106 organisms) or sterile medium. Bacterial infection produced renal abscesses, bacteremia, and late-onset leukocytosis in all animals. Controls were unaffected. This model may be useful for the study of various sequelae of kidney infection.
Linear growth and skeletal maturation in subjects with treated celiac disease.

BACKGROUND The aim of this study was to report on the long-term growth and development in a group of treated patients with celiac disease. METHODS The study includes 26 patients (11 boys and 15 girls) with typical celiac disease who were younger than 2.5 at diagnosis and were followed by means of a growth longitudinal monitoring from the introduction of a gluten-free diet (mean age, 1.7 +/- 0.5 years) until adulthood, over a median period of 15.3 years. Growth indicators used were: height, skeletal age, weight and BMI. RESULTS At the time of admission, the patients had a general tendency to short stature, underweight and retarded skeletal maturation. They did not catch up completely in height and skeletal age after a dietary treatment period of 3 years. Most of them were seen to be slightly below average height for age during childhood and adolescence with skeletal maturity retardation, even if a fairly large interindividual variation of height profiles was evident. CONCLUSIONS Notwithstanding the early treatment, the careful follow-up, and the good adhesion to the dietary rules of the patients under study, slight negative effects of the disease on growth were not avoided.
La retribución de los directivos españoles: marcos teóricos y evidencia empírica

Si bien la retribucion de los altos directivos ha sido un tema de interes para los investigadores desde haca mas da 75 anos, la mayoria de los trabajos se han realizado en al contexto norteamericano, existiendo pocas evidencias empiricas para el caso espanol. En este articulo, tras una revision de los principales marcos teoricos que se han utilizado, efectuamos un estudio sobre una muestra de empresas industriales espanolas en el que intentamos contrastar la existencia de los modelos establecidos en la teoria: algoitmico y experimental. Los resultados de nuestro trabajo son comparados con otros referidos tambien al contexto espanol, poniendose de manifiesto que las empresas presentan, fundamentalmente, un perfil homogeneo y cercano al modelo algoritmico
ACTIVITY OF BROAD‐SPECTRUM ANTIBIOTICS AGAINST ENTEROCOCCI AND THEIR EFFICACY IN ENTEROCOCCAL ENDOCARDITIS *

Enterococci are unique among the streptococci by virtue of their relative resistance to penicillin G and a variety of other antimicrobial agents. The mechanism of this resistance is unknown, but it has great practical significance, because it has made the treatment of enterococcal endocarditis particularly challenging. Soon after the introduction and widespread use of antibiotics, it became apparent that penicillin G was not as effective in the treatment of this infection as it was in endocarditis caused by the highly penicillin-sensitive Streptococcus viridum. For a time, as each new antimicrobial agent appeared on the market it was given a trial in the treatment of enterococcal endocarditis. Results were generally discouraging, and it became clear that bacteriostatic drugs were not dependable in the treatment of this disease. With the recognition of the synergistic bactericidal activity of penicillin G and streptomycin against enterococci, the foundation was laid for the currently recommended treatment of enterococcal endocarditis,' the effectiveness of which is clearly established in the review of Koenig and Kaye.2 While the penicillin-streptomycin regimen is satisfactory from the therapeutic point of view, it involves considerable inconvenience, cost, and the potential risk of ototoxicity. It seems reasonable, then, to evaluate newer antibiotics as possible alternatives that may offer advantages without compromising the positive features of the currently accepted program. The potential of ampicillin in this regard has been previously reportedS and will be reviewed. In addition, the results of limited in vitro tests of other antibiotics against a single strain of enterococcus will be discussed.
Some Toxic Properties of Dimethylnitrosamine

The appearance of two cases of cirrhosis of the liver among three men working in the research laboratory of a large industrial undertaking led to suspicion becoming attached to dimethylnitrosamine (D.M.N.) as the causative agent. Dimethylnitro samine had been introduced into the laboratory as a solvent about 10 months before the first case of cirrhosis was discovered. One of the men had died of bronchopneumonia, and cirrhosis of the liver was an incidental finding at necropsy. The second man with a long-standing history of dyspepsia had a laparotomy after five months' exposure to D.M. N. At that time no note of any abnormality of the liver was made. Six months later he was examined for an incisional hernia that had developed in the operation scar, it was then recorded that the liver felt hard and was suspected of being cirrhotic. Liver function tests carried out at this time showed evidence of damage. When repeated thfee months later after all further exposure to D.M. N. had ceased these tests indicated an improved liver function. The third man has remained in good health but has had no liver function tests carried out on him. A search of the literature revealed only a single short report of the toxic properties of D.M. N. (Hamilton and Hardy, 1949). Dimethylnitrosamine had been used in an automobile factory and some illness had followed. Experiments on dogs showed it to be capable of producing severe liver injury, but no experimental details are provided. The medical officer of the firm therefore asked if we would examine the toxic properties of D.M. N. towards laboratory animals. CH \ Dimethylnitrosamine, ^tT3 >N.NO, is a mobile CH3/ yellow liquid with a faint, characteristic odour. It boils at 151? C. and its specific gravity is 1-015 at 20? C. It is miscible in all proportions with water, ethyl alcohol, m? thyl? ne chloride, or vegetable oil. Under ordinary conditions it is a stable substance, but with zinc dust and acetic acid it can be reduced CH \ to dimethylhydrazine rLr3)N.NH,. CJ-I3/ Preliminary experiments revealed that D.M. N. readily produced a severe liver injury and this paper gives an account of some of the features of the lesions. Materials and Methods
Memory reconsolidation: an update

Memory consolidation refers to the stabilization that a new memory has to undergo in order to persist. Recently, this dominant view of memory has been challenged by renewed interest in reconsolidation, where consolidated memories return to a transient unstable state following their retrieval, from which they must again stabilize in order to persist. In this review, we discuss how reconsolidation is supported by the same line of evidence as consolidation and recent findings of boundary conditions of reconsolidation. Furthermore, we discuss how recent controversies on the nature of amnesia following challenges to reconsolidation are using the same paradigm that failed to resolve the nature of amnesia after challenges to consolidation; we also discuss a new paradigm that can lead to more fruitful ways of studying amnesia in general.
Persistent Luminescence: In Vivo Repeatedly Charging Near‐Infrared‐Emitting Mesoporous SiO2/ZnGa2O4:Cr3+ Persistent Luminescence Nanocomposites (Adv. Sci. 3/2015)

Near‐infrared (NIR) persistent luminescence is an exciting phenomenon in which phosphors can continue to emit photons for weeks after excitation ceases. In article number 1500001, Gang Han and co‐workers report a simple, one‐step mesoporous template method for creating NIR‐emitting nanocomposites based on zinc and gallium. The authors find that the persistent luminescence of the nanocomposites could be repeatedly recharged using white light from a light‐emitting diode (LED) in both a simulated deep‐tissue environment and a live mouse model. This concept paves the way to application of such nanocomposites in the fields of photonics and biophotonics.
Prior Caspofungin Exposure in Patients with Hematological Malignancies Is a Risk Factor for Subsequent Fungemia Due to Decreased Susceptibility in Candida spp.: a Case-Control Study in Paris, France

ABSTRACT Infections due to caspofungin-resistant Candida isolates in patients exposed to caspofungin therapy are increasing. We report here a nested case-control study which aimed at identifying factors associated with bloodstream infections caused by Candida spp. having reduced susceptibility to caspofungin (CRSC) in adults suffering from hematological malignancies. In univariate and multivariate analyses, infections with CRSC were associated with caspofungin exposure in the previous 30 days (odds ratio [OR] = 5.25; 95% confidence interval [95% CI], 1.68–16.35) and with an age of ≤65 years (OR = 3.27; 95% CI, 1.26–8.50).
Evaluation von Veränderungen der kognitiven Geschwindigkeit nach Stentangioplastie mittels funktioneller Kernspintomographie (fMRT)

deutsch Einleitung: Ziel der Studie war es, bei Patienten mit hochgradiger Stenose der Arteria Carotis Interna (ACI) eine Veränderung der kognitiven Geschwindigkeit nach Stentangioplastie (CAS) aufzuzeigen und mittels funktioneller Magnetresonanztomographie (fMRT) zu lokalisieren. Methode: In Vortests wurde an Hand von 10 Personen ein Testverfahren am Computer evaluiert um kognitive Geschwindigkeit zu messen. Insbesondere wurden der Stroopund der Simon Effekt betrachtet. Die Probanden wurden 3 Mal getestet um einen möglichen Lerneffekt zu erfassen. Danach wurden 14 Patienten mit hochgradiger Karotisstenose 24 h vor und 48 h nach Karotisstentangioplastie am Computer neuropsychologisch getestet, 6 Patienten zusätzlich mit Paradigmen in der fMRT. Eine Depression wurde mittels BDI (Beck Depression Inventory) ausgeschlossen. Patienten mit frischen Ischämien in der diffusionsgewichteten Bildgebung (DWI) wurden ausgeschlossen. Nach Stentangioplastie wurden die Patienten wieder sowohl am Computer als auch in der fMRT getestet. Die Ergebnisse wurden mit denen vor dem Eingriff verglichen. Ergebnisse: Es gab keinen signifikanten Lerneffekt (asymptotische Signifikanz = 0,445) nach Wiederholung des Testparadigmas. Patienten und Probanden wiesen in der fMRT eine Aktivierung der Brodman Areale BA 10/11/ACC (anterior cingulate cortex) auf, in welchen der Stroop Effekt abgebildet wird. Nach Stentangioplastie zeigte sich eine signifikant höhere Aktivierung im ACC (p<0,001), der Region, der vor Allem Aufmerksamkeitsprozesse zugeordnet werden. Die Reaktionszeit nach Stentangioplastie nahm ab, dies war jedoch nicht signifikant. Schlussfolgerung: Patienten mit hochgradiger Stenose der Arteria Carotis Interna zeigten nach Stentangioplastie eine erhöhte Aktivierung in den für Aufmerksamkeitsprozesse relevanten Hirnarealen. Somit könnte die Behandlung einer Stenose der Arteria Carotis Interna mehr als nur ein vermindertes Schlaganfallrisiko bewirken.
A Survey on Smart Agent-Based Microgrids for Resilient/Self-Healing Grids

This paper presents an overview of our body of work on the application of smart control techniques for the control and management of microgrids (MGs). The main focus here is on the application of distributed multi-agent system (MAS) theory in multi-objective (MO) power management of MGs to find the Pareto-front of the MO power management problem. In addition, the paper presents the application of Nash bargaining solution (NBS) and the MAS theory to directly obtain the NBS on the Pareto-front. The paper also discusses the progress reported on the above issues from the literature. We also present a MG-based power system architecture for enhancing the resilience and self-healing of the system.
Arginine Decarboxylase and Polyamines Required for Embryogenesis in the Wild Carrot

Embryogenic cultures of Daucus carota treated with 1 millimolar α-difluoromethylarginine, a specific inhibitor of arginine decarboxylase, exhibited nearly a 50 percent reduction in embryo formation compared with controls. Putrescine and spermidine concentrations in the treated cells were greatly reduced. Addition of putrescine, spermidine, or spermine to the culture medium restored embryogenesis in the treated cultures. Embryogenesis was not significantly affected by α-difluoromethylornithine, an inhibitor of ornithine decarboxylase. These results suggest that polyamines have a major function in plant embryo development and that the wild carrot synthesizes polyamines through the biosynthetic pathway involving arginine decarboxylase rather than ornithine decarboxylase.
Prolonged Inhibition of Glutamate Reuptake Down‐Regulates NMDA Receptor Functions in Cultured Cerebellar Granule Cells

Abstract: In the present study, we have examined the effects of prolonged (up to 72 h) inhibition of high‐affinity glutamate reuptake by L‐trans‐pyrrolidine‐2,4‐dicarboxylate (PDC; 100 γM) on glutamate receptor functions in primary cultures of rat cerebellar granule neurons. This was done by comparing the effects of various glutamate receptor agonists on neuronal 45Ca2+ uptake, free cytoplasmic Ca2+ concentration ([Ca2+]i), and cell viability. We also determined the parameters of [3H]MK‐801 binding as well as the expression of the NMDAR1 subunit protein in control and PDC‐exposed cultures. The blockade of glutamate reuptake by PDC led to a gradual increase of ambient glutamate to concentrations that are neurotoxic when applied acutely to control cells. In PDC‐exposed cells, however, the acute glutamate‐induced NMDA receptor‐mediated calcium fluxes were strongly diminished and no toxicity was observed. The down‐regulation of the functional effects of glutamate was dependent on the duration of PDC exposure and was accompanied by a reduced NMDAR1 subunit expression and decreased [3H]MK‐801 binding, indicative of a pronounced structural rearrangement of NMDA receptors. The possibility that the decrease of NMDA glutamate receptor sensitivity can be explained on the basis of a reduced density or altered subunit composition of NMDA receptors is discussed.
A Middleware Application Framework for IOS

For optimal utilization of pervasive architectures, a comprehensive approach to the management of all available resources must be considered. We examine three categories including service-orientated architectures (SOA), human machine interface (HMI) access to existing legacy applications and integration of informational resources (e.g. file systems). To this goal we present an internet operating system (IOS) architecture designed as a middleware application relying on a Representational State Transfer (REST) – based approach. Our framework relies on a novel incorporation of a number of open source technologies including a document-orientated database and server-side Javascript. Initial experiments have demonstrated that our approach performs effectively among the dynamics of our environment.
GreenWay: Joint VM Placement and Topology Adaption for Green Data Center Networking

Energy consumption has become a key issue for running large-scale data center networks (DCN) nowadays. Previous studies mainly focus on energy saving through reducing the number of active servers or network switches with traffic consolidation. However, since this mechanism benefits from the routing flexibility, both the gained energy savings and flow performance are limited by the conventional static network topology. Recent advances in DCN architecture propose to implement an adaptive network topology with reconfigurable optical/wireless links (i.e., topology-adaptive DCNs), which has shown a great potential to improve the transmission performance of existing static wired network. In this paper, we propose GreenWay, an energy-efficient solution to jointly optimize the virtual machine (VM) placement and flow transmissions under the new paradigm of topology adaption. Based on the VM traffic demands, it can construct a proper run-time network topology to lower both the energy cost and communication cost among VMs. We first formulate the energy optimization problem in topology-adaptive DCNs. After showing the its NP-hardness, we then develop heuristic algorithms to address the VM placement and topology adaption effectively. Extensive trace-based simulations show that GreenWay consumes much less energy than other state-of-the- art solutions while ensuring better flow performance. We finally implement an OpenvSwitch- based testbed and demonstrate the efficiency of our solution.
Intraluminal Pressures in the Pelvic Colon

In the true pull-through operations, based on a Bacon-Babcock procedure, the whole rectal ampullary mechanism is removed. The papillary mechanism may or may not be entirely removed, and if the final mucocutaneous anastomosis is within the sphincteric mechanism, there is a chance, at least, of partial continence. The involuntary internal sphincter ani should be left in situ whether the mucosa be removed or not as it may remain relatively tonic and unrelaxing when deprived of its sensory relaxing area, the lower rectal ampulla. If the anal papillary area or at least some of the anal canal skin remains within the sphincteric canal, this may act as a peripheral sensory area allowing the voluntary external sphincter ani to respond and just maintain continence. It is obviously somewhat chancy as there is little time latitude and a rapid response is essential. Fluid faeces, mucus or flatus may easily slip out, with resultant soiling, before the voluntary sphincter has responded. It seems probable therefore that Marden Black's modification of the pull-through operation is likely to be more successful than a truly extrasphincteric anastomosis which relies entirely on sphincteric tonus and a conditioned defeecatory habit as the method of maintaining continence.
Drosophila chitinous aECM and its cellular interactions during tracheal development

The morphology of organs, and hence their proper physiology, relies to a considerable extent on the extracellular matrix (ECM) secreted by their cells. The ECM is a structure contributed to and commonly shared by many cells in an organism that plays an active role in morphogenesis. Increasing evidence indicates that the ECM not only provides a passive contribution to organ shape but also impinges on cell behaviour and genetic programmes. The ECM is emerging as a direct modulator of many aspects of cell biology, rather than as a mere physical network that supports cells. Here, we review how the apical chitinous ECM is generated in Drosophila trachea and how cells participate in the formation of this supracellular structure. We discuss recent findings on the molecular and cellular events that lead to the formation of this apical ECM (aECM) and how it is influenced and affects tracheal cell biology. Developmental Dynamics 245:259–267, 2016. © 2015 Wiley Periodicals, Inc.
Mutant of Bordetella pertussis which lacks ability to produce filamentous hemagglutinin

Mutant cultures that lacked the ability to produce filamentous hemagglutinin were obtained by UV irradiation of Bordetella pertussis strain 18-323. Various biological activities of these mutants were compared with those of the parent culture. It was found that the leukocytosis-promoting, histamine-sensitizing, and mouse-protecting activities of the mutants were similar to those of the parent strain but that the virulence to mice was lower. The results seemed to rule out fimbrial hemagglutinin as a protective antigen when the ability to protect mice was measured by the intracerebral challenge test.
An improved visibility restoration of single haze images for security surveillance systems

With the wide range of features and charms, security surveillance systems are nowadays collective in most industries around the globe. These applications can range from mugging and destruction deterrence to traffic and weather monitoring and more. The surveillance systems are major part in investigations related to crimes and all. But the core problem with the pictures taken with the surveillance system is, it holds many atmospheric particles such as mist, fog, haze, dust etc. By the presence of these particles, the visibility of the images are unfair which poses difficulty in analyzing the image. Image degradation can cause problems for many systems that must operate under a wide range of weather conditions. As such, researchers have been employing various visibility restoration methods to reduce/remove the degradation that has happened while capturing the image. Haze removal is one such visibility restoration practice, which is considered as one of the main reason that is cause degradation in images. Hence, this research emphases on the image degradation that may occur due to haze. Haze is conventionally an atmospheric phenomenon where smoke, dust and other dry particles obscure the transparency of the sky. The dehazing of image is considered quite challenging as the concentration of haze is different for different places, and hence detecting and measuring them is purportedly the greatest challenge. The phenomenon of Color attenuation rollout in images allows us to set the color and intensity of light. Hence, this phenomenon can be used to define the attenuation and hence, can be well used to find the depth of the haze in the images. This research proposes to use the color attenuation prior for single image dehazing. This simple and powerful prior can help to generate a linear model for the scene depth of the hazy image. By learning the parameters of the linear model with a supervised learning method, the link between the hazy image and its corresponding depth map is built effectively. It is thus proposed, to use depth information recovered from the images, to remove the haze from the images.