Miracle-dz/UniFAR-FTUs huggingface dataset:
Casimir Puzzle and Casimir Conundrum: Discovery and Search for Resolution

We review complicated problems in the Lifshitz theory describing the Casimir force between real material plates made of metals and dielectrics including different approaches to their resolution. It has been shown that both for metallic plates with perfect crystal lattices and for any dielectric plates the Casimir entropy calculated in the framework of the Lifshitz theory violates the Nernst heat theorem when the well approved dielectric functions are used in computations. The respective theoretical Casimir forces are excluded by the measurement data of numerous precision experiments. In the literature this situation received the names of the Casimir puzzle and the Casimir conundrum for the cases of metallic and dielectric plates, respectively. The review presents a summary of the main facts on this subject on both theoretical and experimental sides. Next, we discuss the main approaches proposed in the literature in order to bring the Lifshitz theory in agreement with the measurement data and with the laws of thermodynamics. Special attention is paid to the recently suggested spatially nonlocal Drude-like response functions which take into account the relaxation properties of conduction electrons, as does the standard Drude model, but lead to the theoretical results in agreement with both thermodynamics and the measurement data through the alternative response to quantum fluctuations off the mass shell. Further advances and trends in this field of research are discussed.
Mixing, dissipation enhancement and convergence rates for scaling limit of SPDEs with transport noise

We prove the mixing property for stochastic linear transport equations on the torus, and dissipation enhancement in the viscous case. Our approach works also for the scaling limit of stochastic 2D (inviscid) fluid dynamical equations with transport noise to deterministic viscous equations. Quantitative estimates on the convergence rates are provided by combining analytic and probabilistic arguments, especially heat kernel properties and maximal estimates for stochastic convolutions. Similar ideas are applied to the stochastic 2D KellerSegel model, yielding explicit choice of noise to ensure that the blow-up probability is less than any given threshold.
Development and Evaluation of an Automated Manual Resuscitator-Based Emergency Ventilator-Alternative

Mass casualty incidents such as those that are being experienced during the novel coronavirus disease (COVID-19) pandemic can overwhelm local healthcare systems, where the number of casualties exceeds local resources and capabilities in a short period of time. The influx of patients with lung function deterioration as a result of COVID-19 has strained traditional ventilator supplies. To bridge the gap during ventilator shortages and to help clinicians triage patients, manual resuscitator devices can be used to deliver respirations to a patient requiring breathing support. Bag-valve mask (BVM) devices are ubiquitous in ambulances and healthcare environments, however require a medical professional to be present and constantly applying compression to provide the patient with respirations. We developed an automated manual resuscitator-based emergency ventilator-alternative (AMREV) that provides automated compressions of a BVM in a repetitive manner and is broadly compatible with commercially-available BVM devices approximately 5 inches (128 mm) in diameter. The AMREV device relieves the medical professional from providing manual breathing support and allows for hands-free operation of the BVM. The AMREV supports the following treatment parameters: 1) adjustable tidal volume (VT), 2) positive end-expiratory pressure (PEEP) (intrinsic and/or external), 3) 1:1 inspiratory: expiratory ratio, and 4) a controllable respiratory rate between 10-30 breaths per minute. The relationship between the inherent resistance and compliance of the lung and the delivered breaths was assessed for the AMREV device. Adjustable VT of 110-700 ml was achieved within the range of simulated lung states. A linear increase in mean airway pressure (Paw), from 10-40 cmH2O was observed, as the resistance and compliance on the lung model moved from normal to severe simulated disease states. The AMREV functioned continuously for seven days with less than 3.2% variation in delivered VT and Paw. Additionally, the AMREV device was compatible with seven commercially-available BVM setups and delivered consistent VT and Paw within 10% between models. This automated BVM-based emergency-use resuscitator can provide consistent positive pressure, volume-controlled ventilation over an extended duration when a traditional ventilator is not available. True ventilator shortages may lead to manual resuscitators devices such as the AMREV being the only option for some healthcare systems during the COVID-19 pandemic.
Short-Term Effect of Inhaled Salbutamol on Heart Rate in Healthy Volunteers

Objective Tachycardia is a potential side effect of salbutamol inhalation. We aimed to study the short-term effect of salbutamol nebulization on the heart rate of healthy volunteers. Material and methods A randomized, single-blinded, placebo-controlled, cross-over study was conducted with 30 healthy volunteers divided into two groups of 15 each. One group was nebulized with salbutamol (2.5 mg/2 ml dilution) while the other group was given normal saline (2 ml). Each arm underwent administration of the opposite drug the following week. Baseline readings of heart rate and blood pressure were taken at zero (T0), seven (T7), 15 (T15), and 30 (T30) minutes. Results Thirty volunteers between the ages of 20 and 25 years were studied. The mean heart rate value was higher for nebulized salbutamol at each point as compared to saline. When nebulized with salbutamol, the heart rate had a significant rise (p= < 0.00001) at 15 minutes as compared to saline nebulization. Conclusion Salbutamol nebulization, even at a low dose, can lead to a significant increase in heart rate when compared to nebulization with normal saline in healthy individuals.
ADSORPTIVE SEPARATION OF RHODIUM(III) USING FE(III)-TEMPLATED OXINE TYPE OF CHEMICALLY MODIFIED CHITOSAN

ABSTRACT The oxine type of chemically modified chitosan was prepared by the template crosslinking method using Fe(III) as a template ion. Batchwise adsorption of rhodium(III) on this chemically modified chitosan was examined from chloride media in the absence and presence of a large amount of tin(II). It was observed that the Fe(III)- templated oxine type of chemically modified chitosan shows better performance for rhodium adsorption than that of the original chitosan. When Sn(II) is absent from the solution, Rh(III) is hardly adsorbed on the modified chitosan and the order of selectivity of the adsorption of Rh(HI), Pt(IV), and Cu(II) was found to be Pt(IV)> Cu(II) ≈ Rh(IH). On the other hand, adsorption of rhodium is significantly increased in the presence of Sn(II) and the selectivity order of the adsorption was drastically changed to Rh(III) > Pt(IV) ≫ Cu(II), which ensures selective separation of Rh(III) from their mixture. Adsorption of Rh(III) increases with an increase in the concentra- tion of Sn.
Sexual and reproductive health services utilisation amongst in-school young people with disabilities in Ghana

Background Sexual and reproductive health (SRH) of young people including those with disabilities is a major public health concern globally. However, available evidence on their use of sexual and reproductive health services (SRHS) is inconsistent. Objective This study investigated utilisation of SRHS amongst the in-school young people with disabilities (YPWDs) in Ghana using the healthcare utilisation model. Methods Guided by the cross-sectional study design, a questionnaire was used to obtain data from 2114 blind and deaf pupils or students in the age group 10-24 years, sampled from 15 purposively selected special schools for the deaf and the blind in Ghana. Results About seven out of every 10 respondents had ever utilised SRHS. The proportion was higher amongst the males (67.8%) compared with the females (62.8%). Young persons with disabilities in the coastal (OR = 0.03, 95% CI = 0.01–0.22) and middle (OR = 0.06, 95% CI = 0.01–0.44) zones were less likely to have ever utilised SRHS compared with those in the northern ecological zone. The blind pupils or students were more likely to have ever utilised SRHS than the deaf (OR = 1.45, 95% CI = 1.26–3.11). Conclusions Generally, SRHS utilisation amongst the in-school YPWDs in Ghana is high but significantly associated with some predisposing, need and enabling or disabling factors. This underscores the need for policymakers to consider in-school YPWDs as a heterogeneous group in the design and implementation of SRHS programmes. The Ghana Education Service in collaboration with the Ghana Health Service should adopt appropriate pragmatic measures and targeted interventions in the special schools to address the SRH needs of the pupils or students.
Development of a Smart Hallway for Marker-Less Human Foot Tracking and Stride Analysis

Objective: In this research, a marker-less ‘smart hallway’ is proposed where stride parameters are computed as a person walks through an institutional hallway. Stride analysis is a viable tool for identifying mobility changes, classifying abnormal gait, estimating fall risk, monitoring progression of rehabilitation programs, and indicating progression of nervous system related disorders. Methods: Smart hallway was build using multiple Intel RealSense D415 depth cameras. A novel algorithm was developed to track a human foot using combined point cloud data obtained from the smart hallway. A method was implemented to separate the left and right leg point cloud data, then find the average foot dimensions. Foot tracking was achieved by fitting a box with average foot dimensions to the foot, with the box’s base on the foot’s bottom plane. A smart hallway with this novel foot tracking algorithm was tested with 22 able-bodied volunteers by comparing marker-less system stride parameters with Vicon motion analysis output. Results: With smart hallway frame rate at approximately 60fps, temporal stride parameter absolute mean differences were less than 30ms. Random noise around the foot’s point cloud was observed, especially during foot strike phases. This caused errors in medial-lateral axis dependent parameters such as step width and foot angle. Anterior-posterior dependent (stride length, step length) absolute mean differences were less than 25mm. Conclusion: This novel marker-less smart hallway approach delivered promising results for stride analysis with small errors for temporal stride parameters, anterior-posterior stride parameters, and reasonable errors for medial-lateral spatial parameters.
Femoral head mosaicplasty by direct anterior approach for an osteochondral impaction without performing surgical hip dislocation

Several surgical methods exist for the treatment of osteochondral lesions of the femoral head. They include osteochondral allograft transfer, femoral osteotomy, microfracture, autologous chondrocyte implantation, and hip arthroplasty. Mosaicplasty is a surgical method in which cylindrical plugs of bone and cartilage are transferred from a donor site to tunnels drilled into the bone and cartilage defects. This paper discusses the use of mosaicplasty by a direct anterior approach without dislocation in the treatment of an acute femoral head osteochondral impaction in a young patient.
Protection/Deprotection-Free Syntheses and Structural Analysis of (Keto-aryl)diynes

The reactions of precursors 4-BrC6H4COR with TMSC≡CH (Sonogashira coupling) followed by in situ deprotection and subsequent dimerization gave thermally stable dimeric keto-diynes RCOC6H4(C≡C)2C6H4COR (8–11) as yellow powders in 25–85 % yields without the necessity of carbonyl group protection/deprotection steps. Compounds 8–11 were also synthesized by an alternative method that utilized α-haloalkynes previously obtained directly from TMS-protected 4-RCOC6H4C≡CTMS alkynes. The resulting diynes were characterized by spectroscopic methods and in most cases by X-ray crystallography. Careful analysis of the crystal data revealed a surprisingly high degree of chain curvature. Moreover, compounds 9 (R = Me) and 10 (R = Et) were extremely flat, which greatly facilitates electronic communication throughout the whole molecule. Deeper analysis of the packing motifs showed 9 to have a great potential for topochemical 1,4-polymerization. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
“Telephone consultation for medical emergencies” – development, implementation and evaluation of a course in identifying and handling medical emergencies via telephone for 5th year medical students

Objectives: Advising patients seeking medical guidance while communicating with them via telephone is a highly relevant skill in clinical daily life. However, telephone consultations differ from face-to-face interactions: clinical examination is nearly impossible and visual signals cannot be observed. Thus, telephone consultations require specific skills training. This article describes the development, implementation and evaluation of a course, “Telephone Consultation for Medical Emergencies”, for 5th year medical students at the University of Bern, Switzerland. Methods: Following the evidence in the literature for telephone consultations, we developed guidelines for effective communication via telephone. After self-study of preparatory material, learners engaged in telephone consultations with simulated patients (SP) at the simulation center. They received multi-dimensional feedback regarding the encounter. Results: The course was successfully implemented in 2012. Evaluations showed the course to be well-received by students. In a survey, students agreed that they had learned many new skills and that they considered this learning as being important in their future employment. They felt that the SP feedback was helpful and that being observed by peer-students during the encounter or filling in a checklist while observing peer-students in other encounters added to their learning. During the debriefing of the simulation with a clinical expert, students judged the scenarios as realistic and relevant, praised the SP performances and identified that the most instructive aspect of the training was the opportunity to practice and to get feedback. Conclusion: Telephone consultations require specific skills that should be trained. The current Covid-19 pandemic and the recommendations of government institutions for patients to contact healthcare professionals primarily via telephone stress the importance of adequately training these skills. In this publication we describe a feasible and viable format for implementing this process.
Association of Chronic Obstructive Pulmonary Disease with Morbidity and Mortality in Patients with Peripheral Artery Disease: Insights from the EUCLID Trial

Background Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of developing lower extremity peripheral artery disease (PAD) and suffering PAD-related morbidity and mortality. However, the effect and burden of COPD on patients with PAD is less well defined. This post hoc analysis from EUCLID aimed to analyze the risk of major adverse cardiovascular events (MACE) and major adverse limb events (MALE) in patients with PAD and concomitant COPD compared with those without COPD, and to describe the adverse events specific to patients with COPD. Methods EUCLID randomized 13,885 patients with symptomatic PAD to monotherapy with either ticagrelor or clopidogrel for the prevention of MACE. In this analysis, MACE, MALE, mortality, and adverse events were compared between groups with and without COPD using unadjusted and adjusted Cox proportional hazards model. Results Of the 13,883 patients with COPD status available at baseline, 11% (n=1538) had COPD. Patients with COPD had a higher risk of MACE (6.02 vs 4.29 events/100 patient-years; p<0.001) due to a significantly higher risk of myocardial infarction (MI) (3.55 vs 1.85 events/100 patient-years; p<0.001) when compared with patients without COPD. These risks persisted after adjustment (MACE: adjusted hazard ratio (aHR) 1.30, 95% confidence interval [CI] 1.11–1.52; p<0.001; MI: aHR 1.45, 95% CI 1.18–1.77; p<0.001). However, patients with COPD did not have an increased risk of MALE or major bleeding. Patients with COPD were more frequently hospitalized for dyspnea and pneumonia (2.66 vs 0.9 events/100 patient-years; aHR 2.77, 95% CI 2.12–3.63; p<0.001) and more frequently discontinued study drug prematurely (19.36 vs 12.54 events/100 patient-years; p<0.001; aHR 1.34, 95% CI 1.22–1.47; p<0.001). Conclusion In patients with comorbid PAD and COPD, the risks of MACE, respiratory-related adverse events, and premature study drug discontinuation were higher when compared with patients without COPD. Registration ClinicalTrials.gov: NCT01732822.
Elongational Rheometry for the Characterization of Viscoelastic Liquids

A method of elongational rheometry suitable for the characterization of the behavior of viscoelastic polymer solutions in elongational flows is presented. The rheometer, which can also be used with Newtonian fluids, optically measures the temporal evolution of the diameter of a liquid thread. From measurements with viscoelastic fluids, the relaxation time and the steady terminal elongational viscosity of the liquid are deduced. The mutual dependency of the two quantities is different for nonionic and ionic polymers, which exhibit, respectively, flexible and rigid behavior in elongational flows. The influence of the molecular flexibility on the behavior of the polymers in elongational flows can therefore be identified from the measurement results. It is shown that the measured quantities are suitable for characterizing the viscoelastic liquid behavior in elongational flows with free surfaces, which occur, e.g., in liquid atomization by prefilming atomizers.
Age-Specific Dose Regimens of Dexmedetomidine for Pediatric Patients in Intensive Care Following Elective Surgery: A Phase 3, Multicenter, Open-Label Clinical Trial in Japan

Supplemental Digital Content is available in the text. OBJECTIVES: To demonstrate the efficacy, safety, and pharmacokinetics of dexmedetomidine as a potential sedative for pediatric surgery patients in the ICU. DESIGN: Phase 3, multicenter, open-label study. SETTING: This study included 61 patients at 13 tertiary hospitals in Japan. PATIENTS: Pediatric patients (≥ 45 wk corrected gestational age to < 17 yr) undergoing intensive care treatment with mechanical ventilation requiring greater than 6 hours estimated duration of sedation following elective cardiac surgery. INTERVENTIONS: Dexmedetomidine was IV administered without a loading dose at age-specific dose regimens 0.2–1.4 (< 6 yr) and 0.2–1.0 µg/kg/hr (≥ 6 yr). The primary endpoint was the percentage of patients who did not require a rescue sedative (midazolam) infusion during mechanical ventilation or for the first 24 hours of a greater than 24 hours ventilation following the commencement of dexmedetomidine administration. MEASUREMENTS AND MAIN RESULTS: Overall, 47 of the 61 patients (77.0%) did not require rescue midazolam. Adverse events were reported in 53 patients (86.9%). Frequently observed adverse events were hypotension (47.5%), bradycardia (31.1%), and respiratory depression (26.2%). Most of these adverse events were mild, a few moderate, and none severe. Although serious adverse events occurred in four patients, including one cardiac tamponade resulting in the withdrawal of dexmedetomidine, none of the adverse events resulted in mortality or were directly related to dexmedetomidine. The plasma dexmedetomidine concentration generally reached the target concentration of 0.3–1.25 ng/mL at 1–2 hours prior to completion of administration or immediately prior to the commencement of tapering. CONCLUSIONS: The age-specific dose regimens of dexmedetomidine without an initial loading dose achieved an adequate sedation level during mechanical ventilation and caused no clinically significant adverse events in the intensive care pediatric patients. These effects were achieved within the therapeutic range of dexmedetomidine plasma concentration and were accompanied by minimal effects on hemodynamics and respiration.
Efficacy of different combinations of physiotherapy techniques compared to exercise and patient education in temporomandibular disorders: A randomized controlled study

ABSTRACT Objective This study aims to investigate the efficacy of different types of physiotherapy approaches in individuals with cervical myofascial painful temporomandibular disorders (TMDs). Methods Seventy-five participants with myofascial pain of jaw muscles and cervical myofascial pain were randomized into three groups: exercise group (E), low-level laser therapy group (LLLT), and manual pressure release group (MPR). All patients were assessed before treatment and after 12 sessions of treatment. Results Significant improvement was seen in all groups’ pressure pain threshold (PPT) values (p < 0.01). Some masticatory and neck muscles’ PPT changes in MRP and LLLT groups were significantly higher than the exercise group (p < 0.05). Conclusion Exercise therapy is an effective approach for treatment of TMDs. Additionally, LLLT combined with exercise and MPR combined with exercise have better effects than only exercise therapy. Multimodal treatment approaches should include exercise to achieve better results in clinical practice.
Surface engineering of biomaterials in orthopedic and dental implants: Strategies to improve osteointegration, bacteriostatic and bactericidal activities

The success of biomedical implants in orthopedic and dental applications is usually limited due to insufficient bone‐implant integration, and implant‐related infections. Biointerfaces are critical in regulating their interactions and the desirable performance of biomaterials in biological environment. Surface engineering has been widely studied to realize better control of the interface interaction to further enhance the desired behavior of biomaterials.
Social media in health communication: A literature review of information quality

Background: Social media is used in health communication by individuals, health professionals, disease centres and other health regulatory bodies. However, varying degrees of information quality are churned out daily on social media. This review is concerned with the quality of Social Media Health Information (SMHI). Objective: The review sought to understand how SMHI quality issues have been framed and addressed in the literature. Health topics, users and social media platforms that have raised health information quality concerns are reviewed. The review also looked at the suitability of existing criteria and instruments used in evaluating SMHI and identified gaps for future research. Method: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the forward chaining strategy were used in the document search. Data were sourced according to inclusion criteria from five academic databases, namely Scopus, Web of Science, Cochrane Library, PubMed and MEDLINE. Results: A total of 93 articles published between 2000 and 2019 were used in the review. The review revealed a worrying trend of health content and communication on social media, especially of cancer, dental care and diabetes information on YouTube. The review further discovered that the Journal of the American Medical Association, the DISCERN and the Health on the Net Foundation, which were designed before the advent of social media, continue to be used as quality evaluation instruments for SMHI, even though technical and user characteristics of social media differ from traditional portals such as websites. Conclusion: The study synthesises varied opinions on SMHI quality in the literature and recommends that future research proposes quality evaluation criteria and instruments specifically for SMHI.