Miracle-dz/UniFAR-FTUs huggingface dataset:
BENEFICIAL EFFECT OF NISHAAKATHAKAADHI KASHAYAM ON STREPTOZOTOCIN INDUCED DIABETES AND GLUCOSE METABOLIC ENZYMES

Polyherbal traditional formulation Nishaakathakaadhi Kashayam elicit antihyperglycemic effects in streptozotocin induced hyperglycemic rats. Nishaakathakaadhi Kashayam 0.6 ml/kg, p.o. significantly reduced the fasted blood glucose level after 60 days of treatment in diabetic rats. The Kashayam also reduced serum cholesterol, triglycerides, LDL, VLDL, alanine transaminase, aspertate transaminase, alkaline phophatase and urea whereas increased HDL, albumin, protein and haemoglobin levels become normal after the treatment. Glycolytic enzyme showed a significant increases in Streptozotocin induced condition while a significant decrease were observed in levels of the gluconeogenic enzymes in Nishaakathakaadhi Kashayam treated diabetic rats. The Kashayam was non-significantly active with standard drug Glibenclamide (0.6 mg/kg, p.o.). The Kashayam has a positive effect on the histopathological changes of the pancreatic beta cells in Streptozotocin induced diabetic rats. The results suggest that Nishaakathakaadhi Kashayam possesses potential antihyperglycemic effect by regulating glucose homeostasis in streptozotocin induced diabetic rats. The scientific evidences to antidiabetic use suggest that administration of polyherbal formulation to rats, in a dosage used safely by humans, reduces the production of various diabetes causing biochemical parameters and concomitantly prevents the development of Type 2 (NIDDM) diabetes in established animal models. A combination of different herbals in NKK is used to get the enhanced desired activity.
Effect of intratumoral (IT) injection of the toll-like receptor 4 (TLR4) agonist G100 on a clinical response and CD4 T-cell response locally and systemically.

71Background: Soft tissue sarcomas (STS) are heterogeneous tumors which are morbid and lethal. G100 is under investigation in multiple clinical trials and contains a potent TLR4 agonist (oil-in-water emulsion of glucopyranosyl lipid A) that has been tested as vaccine adjuvant. We hypothesized IT G100 would induce robust local and potentially systemic anti-tumor immune response, leading to improved outcomes. Methods: 15 metastatic STS patients with superficial lesions were treated with weekly IT G100 for 8-12 wks; 12 patients received radiation (RT) for 2 wks to start, while 3 received IT G100 for 6 wks prior to RT. Biopsies and PBMC were collected pre and post treatment, and flow cytometry was performed on biopsies. TIL and PBMC were analyzed with TCR deep sequencing. PBMC were analyzed by single cell multiplex cytokine profiling. Results: No grade ≥ 3 toxicity was observed, and local tumor control was achieved in all evaluable tumors (14/14). Treated tumors tracked post-trial (mean 156 days) had persiste.
Privatised sources of funding and the spatiality of inequities in public education

ABSTRACT K-12 public education finance policy in the province of British Columbia, Canada, responsibilises school district administrators to engage in competitive entrepreneurial practices, not only to increase public funding, but also to generate supplementary funding from private sources. We focus specifically on the generation of revenue from international student tuition. Our goal is to deepen our understanding of the spatial dimensions of inequities within the context of marketised education finance using the conceptual framework of spatiality and a mixed-methods approach to data collection. Quantitative data demonstrate how the amount of revenue generated from international student tuition differs between geographically diverse school districts. Qualitative data illuminate how the spatial contexts of local school districts shape administrators’ reasoning, decision making, and marketing practices within a marketised education finance system. Both sets of data illustrate how spatiality exacerbates inequities within a market-oriented approach to education finance.
De-Europeanisation and Equal Citizenship in Turkey: The Case of Circassians

ABSTRACT The Europeanisation process in Turkey that extended roughly from 1999 to 2006 boosted the political and cultural rights of diverse ethnic groups in Turkey, including Circassians, and strengthened their claims for equal citizenship. With the loss or weakening of the EU as an anchor for democratic reform in the post-2007 period, however, the de-Europeanisation process has resulted in the disappearance of the main legal and institutional basis for the democratic integration of ethnocultural minorities. Nevertheless, analysis of the activities of four large Circassian communities in Turkey shows that the same process has enhanced the cultural reification of these groups as their survival strategy.
Bridgmanite crystal chemistry and iron content in the Earthʹs lower mantle

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Linguistically Aided Speaker Diarization Using Speaker Role Information

Speaker diarization relies on the assumption that speech segments corresponding to a particular speaker are concentrated in a specific region of the speaker space; a region which represents that speaker's identity. These identities are not known a priori, so a clustering algorithm is typically employed, which is traditionally based solely on audio. Under noisy conditions, however, such an approach poses the risk of generating unreliable speaker clusters. In this work we aim to utilize linguistic information as a supplemental modality to identify the various speakers in a more robust way. We are focused on conversational scenarios where the speakers assume distinct roles and are expected to follow different linguistic patterns. This distinct linguistic variability can be exploited to help us construct the speaker identities. That way, we are able to boost the diarization performance by converting the clustering task to a classification one. The proposed method is applied in real-world dyadic psychotherapy interactions between a provider and a patient and demonstrated to show improved results.
The fungal collaboration gradient dominates the root economics space in plants

Collaboration broadens the “root economics space” ranging from “do-it-yourself” to “outsourcing” to mycorrhizal partners. Plant economics run on carbon and nutrients instead of money. Leaf strategies aboveground span an economic spectrum from “live fast and die young” to “slow and steady,” but the economy defined by root strategies belowground remains unclear. Here, we take a holistic view of the belowground economy and show that root-mycorrhizal collaboration can short circuit a one-dimensional economic spectrum, providing an entire space of economic possibilities. Root trait data from 1810 species across the globe confirm a classical fast-slow “conservation” gradient but show that most variation is explained by an orthogonal “collaboration” gradient, ranging from “do-it-yourself” resource uptake to “outsourcing” of resource uptake to mycorrhizal fungi. This broadened “root economics space” provides a solid foundation for predictive understanding of belowground responses to changing environmental conditions.
Encouraging Attention and Exploration in a Hybrid Recommender System for Libraries of Unfamiliar Music

There are few studies of user interaction with music libraries comprising solely of unfamiliar music, despite such music being represented in national music information centre collections. We aim to develop a system that encourages exploration of such a library. This study investigates the influence of 69 users’ pre-existing musical genre and feature preferences on their ongoing continuous real-time psychological affect responses during listening and the acoustic features of the music on their liking and familiarity ratings for unfamiliar art music (the collection of the Australian Music Centre) during a sequential hybrid recommender-guided interaction. We successfully mitigated the unfavorable starting conditions (no prior item ratings or participants’ item choices) by using each participant’s pre-listening music preferences, translated into acoustic features and linked to item view count from the Australian Music Centre database, to choose their seed item. We found that first item liking/familiarity ratings were on average higher than the subsequent 15 items and comparable with the maximal values at the end of listeners’ sequential responses, showing acoustic features to be useful predictors of responses. We required users to give a continuous response indication of their perception of the affect expressed as they listened to 30-second excerpts of music, with our system successfully providing either a “similar” or “dissimilar” next item, according to—and confirming—the utility of the items’ acoustic features, but chosen from the affective responses of the preceding item. We also developed predictive statistical time series analysis models of liking and familiarity, using music preferences and preceding ratings. Our analyses suggest our users were at the starting low end of the commonly observed inverted-U relationship between exposure and both liking and perceived familiarity, which were closely related. Overall, our hybrid recommender worked well under extreme conditions, with 53 unique items from 100 chosen as “seed” items, suggesting future enhancement of our approach can productively encourage exploration of libraries of unfamiliar music.
Multiple Myeloma Presenting with Nstemi

Abstract Multiple myeloma, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies. Multiple myeloma is associated with hyperviscosity of the blood depending on the properties of the para-protein. Here we are reporting a case of multiple myeloma presented with a cute coronary syndrome with Troponin T positive with regional wall motion abnormality but with normal coronaries.
Knee Pain in Adults with an Osteopathic Component

The incidence of knee pain is increasing due to the rising prevalence of obesity, sedentary lifestyles, and aging baby boomer population in the United States. Both acute and chronic knee conditions can result in the increased utilization of pain medications and a decreased quality of life. A multimodal approach to knee pain management can thus greatly benefit the patient population and decrease the burden of knee conditions on the healthcare system. This article presents the epidemiology, clinically relevant anatomy, physiology and major risk factors associated with common knee pain conditions. An overview of etiologies is presented in terms of major clinical presentation, diagnostic testing, and treatments. Practical guidelines for an osteopathic approach to the examination and diagnosis of knee pain are then discussed, with a focus on the osteopathic structural exam and the use of special tests to discern and localize soft tissue injury. A novel diagnostic algorithm summarizing a step-by-step approach to a patient with knee pain is also presented. This method integrates the physical exam, special tests, lab work, and imaging to formulate an evidence-based protocol for formulating a knee pain diagnosis. Finally, the article presents management strategies for common causes of knee pain including conservative, pharmacologic, manipulative, and alternative/complementary treatments. Evidence-based recommendations for manipulation efficacy are reviewed from meta-analysis data, randomized controlled trials, and a case report. The article also provides a description of commonly used manipulation techniques and their indications with respect to the anatomic location of knee pain and its underlying etiology.
ارائه مدل توسعه پایدار صنعت فولاد با رویکرد ترکیبی ISM-ANP

دیکچ ه یتایح شقن هزورما ياهرایعم یتسیز طیحم رانک رد نامزاس شلات هدافتسا روظنم هب اه زا اراک و رثؤم عبانم و یعامتجا لئاسم نینچمه ، تسا هدش رادیاپ هعسوت هب هژیو هجوت هب رجنم . یفرط زا دش و ت ترورض یتسیز طیحم لئاسم تیاعر دلاوف عیانص رد ) ههد دنچ ناریا رد هک دراد تمدق ( هراومه دروم هتفرگ رارق دیکأت تسا . زا ا یا رد ور نی هدش ششوک هلاقم ن تسا هشوخ هب ات ییانبریز رصانع يدنب دوش هتخادرپ دلاوف نیمأت هریجنز يرادیاپ . بیترت نیا هب شیپ تاعلاطم هب هجوت اب اب هبحاصم و نی اسانش رصانع نیا هعومجم ،ناگربخ ی ی دندش و يریسفت يراتخاس يزاسلدم کینکت زا هدافتسا اب
Study of Role of Surfactant Protein-D, Malondialdehyde, Protein Carbonyland its Correlation with Airflow Obstruction (FEV1% Predicted) inPatients with Smoker Chronic Obstructive Pulmonary Disease (COPD)

Background: Smokers lungs are exposed to rich amounts of oxidants. Oxidative stress and inflammation are hallmarks of chronic obstructive pulmonary disease. SP-D is lung specific protein play important role in the lungs including regulation of surfactant homeostasis in the alveoli and modulation of host defense system in the lung. The aim of this study was to examine role of surfactant protein-D, malondiladehyde and protein carbonyl in smoker COPD patients and to see whether there is any correlation between pulmonary function test with MDA, PC and SP-D in COPD patients. Materials and methods: We measured serum SP-D, MDA and PC in 30 smoker COPD patients, 30 non-smoker COPD patients and in 30 healthy controls by ELISA and spectrophotometric methods respectively. Results: Serum levels of SP-D, MDA and PC were significantly higher in smoker COPD patients than non-smoker COPD patients. SP-D, MDA and PC were significantly increased in smoker COPD patients as compared to healthy controls. We found inverse correlation between FEV1% predicted with SP-D, MDA and PC in COPD patients. MDA and PC were directly correlated with SP-D in COPD patients. Conclusion: From these findings we conclude that deleterious effect tobacco smoke causes lipid and protein oxidation and lung tissue damage. Lung tissue injury causes release of SP-D in the blood stream. This is directly related with extent of injury and pulmonary function in COPD patients.
Direct ETTIN-auxin interaction controls chromatin states in gynoecium development

Hormonal signalling in animals often involves direct transcription factor-hormone interactions that modulate gene expression1, 2. In contrast, plant hormone signalling is most commonly based on de-repression via the degradation of transcriptional repressors3. Recently, we uncovered a non-canonical signalling mechanism for the plant hormone auxin in organ development with strong similarity to animal hormonal pathways. In this mechanism, auxin directly affects the activity of the auxin response factor ETTIN (ETT) towards regulation of target genes without the requirement for protein degradation4, 5. Here we show that auxin binds ETT to modulate gene expression and that this ETT-auxin interaction leads to the dissociation of ETT from co-repressor proteins of the TOPLESS/TOPLESS-RELATED family followed by histone acetylation and the induction of target gene expression. Whilst canonical ARFs are classified as activators or repressors6, ETT is able to switch chromatin locally between repressive and de-repressive states in an instantly-reversible auxin-dependent manner.
Hamstring Strain Injuries: Incidence, Mechanisms, Risk Factors, and Training Recommendations

Hamstring strain injury (HSI) is one of the most commonly reported sports injuries. This has led to a substantial amount of research aimed at identifying factors that increase the risk of an athlete suffering a HSI. The identification of risk factors allows practitioners to plan intervention programmes with the aim of reducing the rate and severity of HSI. As a multitude of factors contribute to the risk of HSI, interventions should be multifaceted in nature. This review outlines the incidence, mechanisms and risk factors for HSI and provides evidence-based training recommendations to reduce the rate and severity of HSI.
CONSTITUENTS OF SUSTAINABLE DEVELOPMENT

У статті узагальнено теоретичні положення щодо суті поняття «сталий розвиток», у тому числі з огляду на відмінності в сприйнятті соціально-економічних процесів у різних країнах, варіантність перекладу терміну. Представлено тлумачення концептуальних складових «сталий розвиток». Виокремлено характеристики підходів та теорій до розуміння змісту дефініції. Досліджено еволюційний шлях розвитку концепції сталого розвитку. Представлено змістовне наповнення етапів еволюції концепції. Виділено взаємозв'язані та взаємозалежні підходи концепції сталого розвитку, які забезпечують загальну стійкість системи та розкрито їх зміст Вказано на необхідність раціонального використання обмежених ресурсів, що є в розпорядженні суспільства, і застосування природозберігаючих способів виробництва і технологій. Визначена важливість чіткого розуміння механізмів взаємодії екологічної, соціальної та економічної складових концепції.
PENILAIAN KELAYAKAN EKONOMI INVESTASI PERALATAN TAMBANG MENGGUNAKAN METODE INCREMENTAL COST (STUDI KASUS: EXCAVATOR DOOSAN DX 340 LC-5)

Penambangan merupakan kegiatan padat modal, salah satunya pertimbangan investasi dalam kepemilikan peralatan penambangan. Dalam menentukan kapan harus melakukan investasi peralatan juga harus dipertimbangkan. Alternatif pertimbangan penilaian kelayakan ekonomi dalam investasi terdapat beberapa metode, diantaranya adalah metode average cost dan incremental cost. Analisa kelayakan dimulai dengan membuat model life cycle cost excavator Doosan DX 340 LC-5 untuk mengetahui performa biaya yang ditimbulkan akibat penggunaan alat tersebut. Model life cycle cost dimulai dari data tahun 2012 sampai dengan tahun 2018. Biaya dan harga menggunakan dolar ($), dengan konversi dari rupiah ke dolar adalah Rp. 14.000,-. Harga rental alat excavator Doosan DX 340 LC-5 saat pengambilan data ini adalah $ 25,36/ jam. Harga solar industry yang digunakan adalah $ 0,75/Lt, dan gaji operator sebesar $ 1,75/jam. Dari hasil Analisa penggunaan excavator Doosan 340 DX LC5 saat ini tidak layak jika diteruskan hingga tahun proyek selesai. Untuk melanjutkan sisa proyek tersebut akan lebih baik jika mendatangkan excavator Doosan 340 unit baru dengan metode sewa walaupun harga sewa lebih mahal dari saat ini, tetapi dengan PA unit yang baik maka average unit cost akan lebih menguntungkan dibandingkan tetap menggunakan alat yang lama. Alternatif mendatangkan unit dengan cara membeli alat tidak direkomendasikan karena dilihat dari analisis incremental cost pada cash flow terlihat NPV dan ROR yang lebih kecil sehingga tidak layak secara ekonomi.
Systematically Exploring Associations among Multivariate Data

Detecting relationships among multivariate data is often of great importance in the analysis of high-dimensional data sets, and has received growing attention for decades from both academic and industrial fields. In this study, we propose a statistical tool named the neighbor correlation coefficient (nCor), which is based on a new idea that measures the local continuity of the reordered data points to quantify the strength of the global association between variables. With sufficient sample size, the new method is able to capture a wide range of functional relationship, whether it is linear or nonlinear, bivariate or multivariate, main effect or interaction. The score of nCor roughly approximates the coefficient of determination (R) of the data which implies the proportion of variance in one variable that is predictable from one or more other variables. On this basis, three nCor based statistics are also proposed here to further characterize the intra and inter structures of the associations from the aspects of nonlinearity, interaction effect, and variable redundancy. The mechanisms of these measures are proved in theory and demonstrated with numerical analyses. Introduction Identifying relationships among variables is one of the most critical issues in data analysis and interpretation (Altman and Krzywinski 2015) with a wide range of applications in diverse fields from data science to neuroscience. Nowadays, however, a large data set may contain a vast number of variable pairs and combinations that are difficult to be examined manually (Reshef et al. 2011). Association measures can be used to quickly find out the significant associations scattered in thousands or even millions of potential relationships without modelling the relationships explicitly, and thereby provide valuable knowledge and promising pointers for future study. Consider a data sample {(x(t), y(t))|1≤t≤N} that is observed from an underlying functional relationship expressed as follows. y = f(x) + e = ∑
Compare, evaluate, and estimate chronological age with dental age and skeletal age in 6–14-year-old Himachali children

Introduction: Age estimation is of immense importance not only for personal identification but also for treatment planning in medicine and dentistry. Chronologic age conveys only a rough approximation of the maturational status of a person. Hence, dental and skeletal ages (SAs) have been explored as maturity indicators since decades. Aims And Objectives: To test the applicability of Willem's dental age (DA) assessment methods as well as Mito T SA assessment method in Himachali children. Materials and Methods: The study included 55 subjects (30 males and 25 females) ranging from 6 to 14 years age who require orthodontic intervention. DA estimation was performed from digital orthopantomogram of mandibular teeth of left quadrant using Willem's methods. SA estimation was done from lateral cephalogram using Mito T method. The differences between the chronological age (CA) and the estimated dental and SAs were statistically tested using paired t-test. The correlation between CA, dental, and SA estimation methods was confirmed statistically using Pearson's correlation. Results: Among the age estimation methods used in this study, the Willem's DA estimation method proved to be the most accurate and consistent. Conclusion: Although various age estimation methods do exist, the results are varied in different populations due to ethnic differences. However, till new tables are formulated using greater sample size, the Willem's method can be accurately applied to estimate CA for the population studied.
The “Plastotype Problem” in Ichnological Taxonomy

Abstract When naming ichnotaxa based on uncollectable trace fossils, the holotype is the actual ichnofossil in the outcrop, though some ichnologists identify the holotype as a replica (cast) held in a museum collection, and refer to it as a “plastotype,” although not all such replicas are made from plaster. Nevertheless, through its Code, the International Commission on Zoological Nomenclature (ICZN) makes it clear that an artificial, human-made replica (plaster cast or otherwise) is not eligible to be the holotype of an ichnotaxon. This directive is potentially destabilizing to much ichnological taxonomy, which is based on holotypes left in the field that have disappeared or will disappear. One possible solution for ichnologists will be to petition the ICZN to recognize that artificial, human-made replicas of ichnofossils can serve as name-bearing types. These may best be called “axiotypes” (from the Greek axios, meaning “of equal value”).