Miracle-dz/UniFAR-FTUs huggingface dataset:
Personal Event Management among Multiple Devices Based on User Intention Recognition Using Dynamic Bayesian Networks

This paper proposes a proactive management system for the events that occur across multiple personal user devices, including desktop PCs, laptops, and smart phones. We implemented the Personal Event Management Service using Dynamic Bayesian Networks (PEMS-DBN) system that proactively executes appropriate tasks across multiple devices without explicit user requests by recognizing the user's device reuse intention, based on the observed actions of the user for specific devices. The client module of PEMS-DBN installed on each device monitors the user actions and recognizes user intention by using dynamic Bayesian networks. The server provides data sharing and maintenance for the clients. A series of experiments were performed to evaluate user satisfaction and system accuracy, and also the amounts of resource consumption during intention recognition and proactive execution are measured to ensure the system efficiency. The experimental results showed that the PEMS-DBN system can proactively provide appropriate, personalized services with a high degree of satisfaction to the user in an effective and efficient manner.
Dorsal root ganglion neurons show increased expression of the calcium channel alpha2delta-1 subunit following partial sciatic nerve injury.

Neuropathic pain is associated with changes in the electrophysiological and neurochemical properties of injured primary afferent neurons. A mRNA differential display study in rat L(4/5) dorsal root ganglia (DRGs) revealed upregulation of the calcium channel alpha2delta-1 subunit 2 weeks after partial sciatic nerve ligation (Seltzer model of neuropathic pain). The upregulated transcript appeared to represent previously unidentified sequence from the 3'-untranslated region of rat alpha2delta-1 mRNA. In situ hybridization using L(5) DRGs from sham operated rats showed that 73, 40 and 19% of small (<700 microm(2)), medium (700-1100 microm(2)) and large (>1100 microm(2)) neuronal profiles, respectively, expressed alpha2delta-1 mRNA. Two weeks following nerve injury there was a significant ipsilateral increase, both in the percentage of DRG neurons expressing alpha2delta-1 mRNA and in the intensity of the hybridization signal. Comparison of this ipsilateral expression with that in sham animals, revealed that for small, medium and large neurons, respectively, the proportion of neurons labelled increased by 1.2-, 1.8- and 2.7-fold, while the hybridization signal in alpha2delta-1-labelled neurons increased by 2.8-, 2.5- and 3.7-fold. The most intensely labelled neuronal profiles in ipsilateral, sham and contralateral DRGs, were generally those with small cross-sectional areas. The alpha2delta-1 auxiliary subunit is known to modulate calcium channel function in heterologous expression systems via its association with the pore-forming alpha1 calcium channel subunit. Therefore the increased levels of this subunit in the populations of primary afferents described may, via modulation of calcium-dependent processes such as neurotransmitter release and neuronal excitability, influence the processing of sensory information.
Effects of physical exercise on quality of life, exercise capacity and pulmonary function in children with asthma.

OBJECTIVE To investigate the effects of regular submaximal exercise on quality of life, exercise capacity and pulmonary function in asthmatic children. PATIENTS AND METHODS Sixty-two children with mild-moderate asthma (mean age 10.4 (SD 2.1) years) were randomly allocated into exercise and control groups. The exercise group underwent a moderately intensive basketball training program for 8 weeks. A home respiratory exercise program was advised to both groups. Pediatric Asthma Quality of Life Questionnaire (PAQLQ) was used for the evaluation of activity limitation, symptoms and emotional functions. Exercise capacity was evaluated through the physical work capacity (PWC 170 test) on a cycle ergometer and 6-minute walk test. Spirometric tests were also performed and medication and symptom scores were recorded. RESULTS Although PAQLQ scores improved in both groups, the improvement in the exercise group was significantly higher. The exercise group performed better in the PWC 170 and 6-minute walk tests, whereas no improvement was detected in the control group at the end of the trial. Medication scores improved in both groups, but symptom scores improved only in the exercise group. No significant changes were detected in pulmonary function in either group, except for peak expiratory flow values in the exercise group. CONCLUSION Eight weeks of regular submaximal exercise has beneficial effects on quality of life and exercise capacity in children with asthma. Submaximal basketball training is an effective alternative exercise program for asthmatic children.
Protective Effect of Falcaria vulgaris Extract on Ethanol Induced Gastric Ulcer in Rat

Falcaria vulgaris is a member of Umbelliferae family and is used for treatment of stomach disorders in the folk medicines of the west of Iran. This study was designed to evaluate the gastroprotective effect of F. vulgaris extract on ethanol (50%) induced gastric ulcers in rat. Thirty five young white male rats were divided to five groups (7 rats/ group). Three case groups received plant extract (50, 100, 150 mg/kg) and control negative and positive groups received distilled water and ranitidine respectively. Animals were killed and their stomachs were removed and macroscopic and microscopic ulcer index were determined. Data were subjected to one way ANOVA followed by Dennett’s t-test. The results indicated that hydro alcoholic extract of F. vulgaris (50,100,150 mg/kg) significantly decreased the ulcer index (p<0.05) and these doses of extract exerted macroscopic curative ratios of 66.9%, 76.9% and 80.25% respectively. F. vulgaris extract has gastroprotective effect on ethanol-induced ulcer in rat.
Blunt renal trauma-blessing in disguise?

PURPOSE The purpose of this study was to quantify pathologic lesions of the kidney found incidentally during the workup of a blunt renal trauma. METHODS A retrospective review of the medical records of 103 patients ages 0 to 18 years with blunt renal injuries admitted to a level 1 pediatric trauma center between January 1, 1991 and December 31, 1999 was performed. All patients underwent ultrasonography and Doppler of their renal vessels. Additional investigations with computed tomography (CT) scan, cystography, or nuclear medicine functional studies were performed as indicated. RESULTS Coexisting urogenital lesions were identified in 13 of 103 (12.6%) patients reviewed, and 7 (54%) required surgical treatment. The majority of the patients (9 of 13, 69%) suffered minimal trauma. All patients presented with gross hematuria as their main symptom. Stenosis of the uretero-pelvic junction was the most frequent diagnosis (n = 7): 3 patients required uretero-pyeloplasty, and 3 required nephrectomy. Two heterogeneous renal masses were discovered in which the diagnosis of a malignant process could not be eliminated; elective resection and open biopsy were performed. The diagnoses of multicystic kidney and solitary cyst with complex hematoma, respectively, were confirmed on pathology. Grade III ureterovesical reflux with pyelonephritis (n = 1), polycystic kidney (n = 1), extrarenal pelvis without obstruction (n = 1), and horseshoe kidney (n = 1) were the other lesions discovered. CONCLUSIONS Pathologic lesions of the urinary tract are uncommon; however, they may complicate an otherwise negligible renal trauma. The diagnostic and therapeutic approach to blunt renal trauma must be modified in these cases. A high index of suspicion must be maintained when a patient presents with gross hematuria with a minimal force blunt abdominal trauma.
Blueprints of Effective Biodiversity and Conservation Knowledge Products That Support Marine Policy

Biodiversity and conservation data are generally costly to collect, particularly in the marine realm. Hence, data collected for a given—often scientific—purpose are occasionally contributed towards secondary needs, such as policy implementation or other types of decision-making. However, while the quality and accessibility of marine biodiversity and conservation data have improved over the past decade, the ways in which these data can be used to develop and implement relevant management and conservation measures and actions are not always explicit. For this reason, there are a number of scientifically-sound datasets that are not used systematically to inform policy and decisions. Transforming these marine biodiversity and conservation datasets into knowledge products that convey the information required by policy- and decision-makers is an important step in strengthening knowledge exchange across the science-policy interface. Here, we identify seven characteristics of a selection of online biodiversity and conservation knowledge products that contribute to their ability to support policy- and decision-making in the marine realm (as measured by e.g. mentions in policy resolutions/decisions, or use for reporting under selected policy instruments; use in high-level screening for areas of biodiversity importance). These characteristics include: a clear policy mandate; established networks of collaborators; iterative co-design of a user-friendly interface; standardised, comprehensive and documented methods with quality assurance; consistent capacity and succession planning; accessible data and value-added products that are fit-for-purpose; and metrics of use collated and reported. The outcomes of this review are intended to: (a) support data creators/owners/providers in designing and curating biodiversity and conservation knowledge products that have greater influence, and hence impact, in policy- and decision-making, and (b) provide recommendations for how decision- and policy-makers can support the development, implementation, and sustainability of robust biodiversity and conservation knowledge products through the framing of marine policy and decision-making frameworks.
A prospective cohort study challenging the effectiveness of population-based medical intervention for smoking cessation

Objective To examine the population effectiveness of nicotine replacement therapies (NRTs), either with or without professional counselling, and provide evidence needed to better inform healthcare coverage decisions. Methods A prospective cohort study was conducted in three waves on a probability sample of 787 Massachusetts adult smokers who had recently quit smoking. The baseline response rate was 46%; follow-up was completed with 56% of the designated cohort at wave 2 and 68% at wave 3. The relationship between relapse to smoking at follow-up interviews and assistance used, including NRT with or without professional help, was examined. Results About one-fourth of recent quitters at each wave reported to have relapsed by the subsequent interview. Odds of relapse were unaffected by use of NRT for >6 weeks either with (p=0.117) or without (p=0.159) professional counselling and were highest among prior heavily dependent persons who reported NRT use for any length of time without professional counselling (OR 2.68). Conclusions This study finds that persons who have quit smoking relapsed at equivalent rates, whether or not they used NRT to help them in their quit attempts. Cessation medication policy should be made in the larger context of public health, and increasing individual treatment coverage should not be at the expense of population evidence-based programmes and policies.
A comparison of the degree of curvature in the cancer incidence dose-response in Japanese atomic bomb survivors with that in chromosome aberrations measured in vitro

Purposes : To compare the degree of curvature in the dose-response for chromosome aberrations and for radiation-induced cancer. Materials and methods : Comparison of the ratio of the quadratic and linear coeffcients (in dose) in Japanese atomic bomb survivor cancer incidence data, based on follow-up to 1987 and taking account of random errors in DS86 dose estimates with the same ratio in four datasets of chromosome aberrations in peripheral blood lymphocytes measured in vitro and exposed to 60 Co gamma radiation. Results : There are no statistically significant differences between the four in vitro datasets in the ratio of the quadratic to the linear coeffcients for dicentrics or chromosome translocations, nor are there indications of differences between this ratio for dicentrics and that for complete chromosome translocations (p >0.1 in all cases). If the 0-4 Gy dose range is used in the Japanese atomic bomb survivor data, the ratio of the quadratic to the linear coeffcients for all solid cancers is 0.06 Sv 1 (95% CI 0.22, 0.67) and so is not significantly different from 0; this ratio is statistically highly inconsistent (p <0.0001) with the analogous ratio estimated for the in vitro chromosome aberration data (4.20Sv 1; 95% CI 3.06, 6.51). By contrast, there are no statistically significant differences (p =0.42) between the ratio of the quadratic to the linear coeffcients for leukaemia incidence in the Japanese cohort, 1.81 Sv 1 (95% CI 0.21, > 1000), with that for chromosome aberrations in vitro. These results are not markedly changed if the 0-2 Gy dose range is used in the Japanese atomic bomb survivor data. Conclusions : It is unlikely that in vitro chromosome aberrations could be a correlate for the initiating radiogenic lesions leading to radiation-induced solid cancers. However, taken together with certain other biological information, it may not be unreasonable on this basis to use in vitro chromosome aberrations in peripheral blood lymphocytes as a correlate of the radiogenic lesions leading to radiation-induced leukaemia.
Pressure controlled compression of the breast in mammography

Mammography is a widely used diagnostic modality in radiology and is the starting procedure in almost every work-up in breast imaging whether this is diagnostic, i.e. initiated by clinical signs or in asymptomatic subjects in screening programs. Screening mammography is widely considered as one of the major medical successes of the past decades, and the decline in breast cancer mortality that has been observed in many countries throughout the world has been attributed at least in part to screening programs. Each year, an estimated 125 million women throughout the world are imaged using mammography, a process which involves each woman routinely undergoing two compressions of each breast. A certain level of compression of the breast is required in mammography for several reasons: • Immobilization of the breast is needed to avoid movement and the consequent blurring of images. • Flattening of the breast enables a more homogeneous exposure and a better dynamic range of luminance. • Superimposing structures at different depths and those with different degrees of stiffness can be better depicted in a compressed breast • Last but not least, compression enables a quality image at a lower radiation dose. However, despite the key role of compression, attempts to standardize the procedure have to date been limited to either the subjective judgement of the radiographer (“compress until skin is taut”) or the use of a set amount of force (“apply 130N of force”), which does not take into consideration whether the breast is small or large. Compression which is too great can lead to a painful experience with the woman being less likely to continue to participate in the screening program. To date, efforts to help radiographers achieve the optimal compromise between the pain felt by the woman and image quality have not been successful [1]. In this article we describe the advantages of introducing a more objective, scientific approach to breast compression with the ultimate aim of maintaining high image quality, low radiation dose and at the same time ensuring the most comfortable experience for the woman.
Economic models of animal communication

Many models of animal signal evolution fail to incorporate an explicit strategy for receivers prior to the evolution of signals. When reasonable assumptions are made for such strategies, we have shown that there is a minimal accuracy of signal coding that is required before receivers should attend to signals (Bradbury & Vehrencamp 1998, Principles of Animal Communication). Depending upon the relative payoffs of correct and incorrect decisions by receivers, this minimal accuracy can be quite high. Here we use this result to explain why so many signals appear to be traits that provided useful information to receivers before becoming ritualized into signals. Our model also supports one prediction of sensory drive models: that latent preferences may selectively favour some signal precursors over others. However, it imposes a serious constraint on sensory drive by requiring that there be sufficient benefits to a receiver to compensate for the costs of disrupting the optimal receiver strategy used before exploitation. Finally, we discuss the overlap between signal honesty and accuracy and show how senders that completely disagree with receivers about appropriate receiver decisions may still benefit by providing moderately honest and accurate signals. Copyright 2000 The Association for the Study of Animal Behaviour.
On logic depth per pipelining stage with power aware flop, wave and hybrid pipelining with gate size and area constraints

Power Optimal logic depth per pipeline stage has been explored in several papers in the literature. Simulation results on circuit models with inverters have shown that a logic depth per pipeline stage of 6 to 8 FO4 results in optimal power designs and can save good amount of power compared to a logic depth of 24 F04. In this paper we study power and logic depth trade off on ISCAS-85 benchmark circuits, considering flop, wave and hybrid pipelining architectures with supply and threshold voltage variations under gate size and area constraints. Towards the end we have developed a tool which can be used for designing power efficient digital combinational circuits with flop, wave and hybrid pipelining options under area and gate sizing constraints. We shows that, proper architecture selection results in power savings of 20-90% compared to the worst case power in the given range of logic depths. We also observe that the supply and threshold selection has savings of 10-85%. Our analysis shows that no denite conclusions can be made about logic depth per pipeline stage achievable for a circuit and it depends on the architecture, supply, threshold voltages and gate sizing range and permissible circuit area.
Oligonucleotide‐based microarray for DNA methylation analysis: Principles and applications

Gene silencing via promoter CpG island hypermethylation offers tumor cells growth advantages. This epigenetic event is pharmacologically reversible, and uncovering a unique set of methylation‐silenced genes in tumor cells can bring a new avenue to cancer treatment. However, high‐throughput tools capable of surveying the methylation status of multiple gene promoters are needed for this discovery process. Herein we describe an oligonucleotide‐based microarray technique that is both versatile and sensitive in revealing hypermethylation in defined regions of the genome. DNA samples are bisulfite‐treated and PCR‐amplified to distinguish CpG dinucleotides that are methylated from those that are not. Fluorescently labeled PCR products are hybridized to arrayed oligonucleotides that can discriminate between methylated and unmethylated alleles in regions of interest. Using this technique, two clinical subtypes of non‐Hodgkin's lymphomas, mantle cell lymphoma, and grades I/II follicular lymphoma, were further separated based on the differential methylation profiles of several gene promoters. Work is underway in our laboratory to extend the interrogation power of this microarray system in multiple candidate genes. This novel tool, therefore, holds promise to monitor the outcome of various epigenetic therapies on cancer patients. © 2002 Wiley‐Liss, Inc.
A Comparative Pharmacokinetic Study in Healthy Volunteers of the Effect of Carbamazepine and Oxcarbazepine on Cyp3a4

Summary: Purpose: Carbamazepine (CBZ) and oxcarbazepine (OXCZ) are well‐known inducers of drug metabolism via CYP3A4. Indirect interaction studies and clinical experience suggest that CBZ has a stronger potential in this regard than OXCZ. However this has never been subject to a direct comparative study. We performed a study in healthy volunteers to investigate the relative inductive effect of CBZ and OXCZ on CYP3A4 activity using the metabolism of quinidine as a biomarker reaction.
Hyperbolic localization method for MIMO radar

Classic localization methods in conventional radar cannot be used to multiple-input multiple-output radar directly. In this paper, we proposed a new localization model for MIMO radar system, which make hyperbolic location method can be extended to MIMO radar. TOAs equations are build from multipath between transmitters and receivers to estimate the target position. The equations are redundant since number of paths is more than number of target coordinates. Our new model makes full use of redundant paths to decrease the impact of TOA measurement errors and improve estimation accuracy. Then, we proposed a two-steps method to solve the overdetermined and nonlinear TOAs equations. Different with conventional Taylor expansion method, which needs an initial position closed to the target and iterative process is necessary, we calculate the initial position in first step and use partly Taylor expansion and BLUE algorithm in the second step to obtain accurate results. GDOP performance of the new method is analyzed. CRLB of the proposed algorithm is derived as well and localization error of new algorithm is almost equal to CRLB which prove the value of the new method.
Islanding detection method based on second-order harmonic injection for voltage-controlled inverter

The synchronization between DG and microgird is required in order to prevent high inrush current. This high inrush current may trigger the protection or danger the facility in the system. On the other hand, anti-islanding inverters shall always detect islanding condition when they connect to microgrid. It is required that disconnecting from microgrid in two seconds whenever islanding occurred. General speaking, there are two method to detect islanding-passive and active method. This paper developed a voltage-controlled inverter which could connect to microgrid with synchronization and detect islanding condition actively. According to second harmonic voltage injection method, the proposed inverter detects the second harmonic current to decide whether islanding is happened.
Antifungal Activity of Antidepressant Sertraline against Candida Species In vitro : A Potential Beneficial Association with Fluconazole

Cite this article: Oliveira AS, Martinez-de-Oliveira J, Palmeira-de-Oliveira R, Palmeira-de-Oliveira A, et al. (2017) Antifungal Activity of Antidepressant Sertraline against Candida Species In vitro: A Potential Beneficial Association with Fluconazole. Med J Obstet Gynecol 5(1): 1095. *Corresponding authors Ana Sofia Oliveira, CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal, Tel: 351 917405067; Email