Miracle-dz/UniFAR-FTUs huggingface dataset:
A Meshless Local Petrov-Galerkin Method for Solving the Bending Problem of a Thin Plate

Meshless methods have been extensively popularized in literature in recent years, due to their flex- ibility in solving boundary value problems. The mesh- less local Petrov-Galerkin(MLPG) method for solving the bending problem of the thin plate is presented and discussed in the present paper. The method uses the moving least-squares approximation to interpolate the solution variables, and employs a local symmetric weak form. The present method is a truly meshless one as it does not need a mesh, either for the purpose of inter- polation of the solution or for the integration of the en- ergy. All integrals can be easily evaluated over regularly shaped domains (in general, spheres in three-dimensional problems) and their boundaries. The essential boundary conditions are enforced by the penalty method. Sev- eral numerical examples are presented to illustrate the implementation and performance of the present method. The numerical examples presented in the paper show that high accuracy can be achieved for arbitrary nodal distri- butions for clamped and simply-supported edge condi- tions. No post processing procedure is required to com- pute the strain and stress, since the original solution from the present method, using the moving least squares ap- proximation, is of C 2 type.
Variational Framework for Assessment of the Left Ventricle Motion

Impairment of left ventricular contractility due to cardiovascular diseases is reflected in left ventricle (LV) motion patterns. An abnormal change of torsion or long axis shortening LV values can help with the diagnosis and follow-up of LV dysfunction. Tagged Magnetic Resonance (TMR) is a widely spread medical imaging modality that allows estimation of the myocardial tissue local deformation. In this work, we introduce a novel variational framework for extracting the left ventricle dynamics from TMR sequences. A bi-dimensional representation space of TMR images given by Gabor filter banks is defined. Tracking of the phases of the Gabor response is combined using a variational framework which regularizes the deformation field just at areas where the Gabor amplitude drops, while restoring the underlying motion otherwise. The clinical applicability of the proposed method is illustrated by extracting normality models of the ventricular torsion from 19 healthy subjects.
Fruit Detection and Tree Segmentation for Yield Mapping in Orchards

Accurate information gathering and processing is critical for precision horticulture, as growers aim to optimise their farm management practices. An accurate inventory of the crop that details its spatial distribution along with health and maturity, can help farmers efficiently target processes such as chemical and fertiliser spraying, crop thinning, harvest management, labour planning and marketing. Growers have traditionally obtained this information by using manual sampling techniques, which tend to be labour intensive, spatially sparse, expensive, inaccurate and prone to subjective biases. Recent advances in sensing and automation for field robotics allow for key measurements to be made for individual plants throughout an orchard in a timely and accurate manner. Farmer operated machines or unmanned robotic platforms can be equipped with a range of sensors to capture a detailed representation over large areas. Robust and accurate data processing techniques are therefore required to extract high level information needed by the grower to support precision farming. This thesis focuses on yield mapping in orchards using image and light detection and ranging (LiDAR) data captured using an unmanned ground vehicle (UGV). The contribution is the framework and algorithmic components for orchard mapping and yield estimation that is applicable to different fruit types and orchard configurations. The framework includes detection of fruits in individual images and tracking them over subsequent frames. The fruit counts are then associated to individual trees, which are segmented from image and LiDAR data, resulting in a structured spatial representation of yield. The first contribution of this thesis is the development of a generic and robust fruit detection algorithm. Images captured in the outdoor environment are susceptible to highly variable external factors that lead to significant appearance variations. Specifically in orchards, variability is caused by changes in illumination, target pose, tree types, etc. The proposed techniques address these issues by using state-of-the-art feature learning approaches for image classification, while investigating the utility of orchard domain knowledge for fruit detection. Detection is performed using both pixel-wise classification of images followed instance segmentation, and bounding-box regression approaches. The experimental results illustrate the versatility of complex deep learning approaches over a multitude of fruit types.
Multiday Transcranial Direct Current Stimulation Causes Clinically Insignificant Changes in Childhood Dystonia

Abnormal motor cortex activity is common in dystonia. Cathodal transcranial direct current stimulation may alter cortical activity by decreasing excitability while anodal stimulation may increase motor learning. Previous results showed that a single session of cathodal transcranial direct current stimulation can improve symptoms in childhood dystonia. Here we performed a 5-day, sham-controlled, double-blind, crossover study, where we measured tracking and muscle overflow in a myocontrol-based task. We applied cathodal and anodal transcranial direct current stimulation (2 mA, 9 minutes per day). For cathodal transcranial direct current stimulation (7 participants), 3 subjects showed improvements whereas 2 showed worsening in overflow or tracking error. The effect size was small (about 1% of maximum voluntary contraction) and not clinically meaningful. For anodal transcranial direct current stimulation (6 participants), none showed improvement, whereas 5 showed worsening. Thus, multiday cathodal transcranial direct current stimulation reduced symptoms in some children but not to a clinically meaningful extent, whereas anodal transcranial direct current stimulation worsened symptoms. Our results do not support transcranial direct current stimulation as clinically viable for treating childhood dystonia.
The role of oxygenated cytochrome P-450 and of cytochrome b5 in hepatic microsomal drug oxidations.

An examination of the spectral changes occurring in hepatic microsomes during the aerobic steady state of oxidative drug metabolism has revealed the presence of a spectral species which has been identified as the oxygenated form of ferrous cytochrome P-450. The appearance of this species in hepatic microsomes depends on 1) the presence of a type I substrate which can undergo oxidation, 2) the presence of oxygen, and 3) the use of TPNH as the source of reducing equivalents. The rate of formation of this oxygenated form of cytochrome P-450 is much faster that the overall rate of substrate oxidation and is consistent with the inclusion of this intermediate in the sequence of cyclic reduction and oxidation transitions which cytochrome P-450 undergoes during substrate oxidation. The observation that the presence of drug substrates produces a partial reoxidation of TPNH-reduced cytochrome b 5, thereby resulting in a lower aerobic steady-state level of reduction of this hemoprotein, indicates that cytochrome b 5 may function in hepatic microsomal drug oxidations. It is proposed that reduced cytochrome b 5 may serve in the capacity of an electron transfer intermediate which donates the electron to oxygenated cytochrome P-450 required for substrate oxidation.
Dual calcium ion regulation of calcineurin by calmodulin and calcineurin B.

The dependence of calcineurin on Ca2+ for activity is the result of the concerted action of calmodulin, which increases the turnover rate of the enzyme and modulates its response to Ca2+ transients, and of calcineurin B, which decreases the Km of the enzyme for its substrate. The calmodulin-stimulated protein phosphatase calcineurin is under the control of two functionally distinct, but structurally similar, Ca(2+)-regulated proteins, calmodulin and calcineurin B. The Ca(2+)-dependent activation of calcineurin by calmodulin is highly cooperative (Hill coefficient of 2.8-3), and the concentration of Ca2+ needed for half-maximum activation decreases from 1.3 to 0.6 microM when the concentration of calmodulin is increased from 0.03 to 20 microM. Conversely, the affinity of calmodulin for Ca2+ is increased by more than 2 orders of magnitude in the presence of a peptide corresponding to the calmodulin-binding domain of calcineurin A. Calmodulin increases the Vmax without changing the Km value of the enzyme. Unlike calmodulin, calcineurin B interacts with calcineurin A in the presence of EGTA, and Ca2+ binding to calcineurin B stimulates native calcineurin up to only 10% of the maximum activity achieved with calmodulin. The Ca(2+)-dependent activation of a proteolyzed derivative of calcineurin, calcineurin-45, which lacks the regulatory domain, was used to study the role of calcineurin B. Removal of the regulatory domain increases the Vmax of calcineurin, as does binding of calmodulin, but it also increases the affinity of calcineurin for Ca2+. Ca2+ binding to calcineurin B decreases the Km value of calcineurin without changing its Vmax. (ABSTRACT TRUNCATED AT 250 WORDS)
Phyletic Distribution of Crypt-Type Olfactory Receptor Neurons in Fishes

The olfactory epithelium of teleost fishes contains ciliated and microvillous olfactory receptor neurons intermingled with supporting cells. Recently the crypt cell, a third type of olfactory receptor neuron (ORN), was described for two ostariophysans. This type of ORN bears apical microvilli as well as occult cilia extending into a crypt at the apex of the cell. The present study used scanning and transmission electron-microscopic methods to examine how widespread this cell type is in other groups of fish. We investigated the olfactory epithelia of 18 species, freshwater and marine, including various actinopterygian fish as well as 2 species of lungfishes belonging to the sarcopterygians. Crypt cells were detected in 13 species of actinopterygian fish, but in none of the sarcopterygian lungfishes. Crypt cells are present in basic as well as in highly derived actinopterygians. We conclude that crypt cells are a common feature of actinopterygian fish.
Query-Time Data Integration

Today, data is collected in ever increasing scale and variety, opening up enormous potential for new insights and data-centric products. However, in many cases the volume and heterogeneity of new data sources precludes up-front integration using traditional ETL processes and data warehouses. In some cases, it is even unclear if and in what context the collected data will be utilized. Therefore, there is a need for agile methods that defer the effort of integration until the usage context is established. This thesis introduces Query-Time Data Integration as an alternative concept to traditional up-front integration. It aims at enabling users to issue ad-hoc queries on their own data as if all potential other data sources were already integrated, without declaring specific sources and mappings to use. Automated data search and integration methods are then coupled directly with query processing on the available data. The ambiguity and uncertainty introduced through fully automated retrieval and mapping methods is compensated by answering those queries with ranked lists of alternative results. Each result is then based on different data sources or query interpretations, allowing users to pick the result most suitable to their information need. To this end, this thesis makes three main contributions. Firstly, we introduce a novel method for Top-k Entity Augmentation, which is able to construct a top-k list of consistent integration results from a large corpus of heterogeneous data sources. It improves on the stateof-the-art by producing a set of individually consistent, but mutually diverse, set of alternative solutions, while minimizing the number of data sources used. Secondly, based on this novel augmentation method, we introduce the DrillBeyond system, which is able to process Open World SQL queries, i.e., queries referencing arbitrary attributes not defined in the queried database. The original database is then augmented at query time with Web data sources providing those attributes. Its hybrid augmentation/relational query processing enables the use of ad-hoc data search and integration in data analysis queries, and improves both performance and quality when compared to using separate systems for the two tasks. Finally, we studied the management of large-scale dataset corpora such as data lakes or Open Data platforms, which are used as data sources for our augmentation methods. We introduce Publish-time Data Integration as a new technique for data curation systems managing such corpora, which aims at improving the individual reusability of datasets without requiring up-front global integration. This is achieved by automatically generating metadata and format recommendations, allowing publishers to enhance their datasets with minimal effort. Collectively, these three contributions are the foundation of a Query-time Data Integration architecture, that enables ad-hoc data search and integration queries over large heterogeneous dataset collections.
USA: West Nile virus

There have been 14 cases of West Nile virus (WNV) infection in humans so far this year in the USA, including three new cases that were confirmed in September by the Illinois Department of Public Health. All three new cases were men older than 50 years of age. In the USA, WNV first appeared in New York in 1999 and in Illinois in 2001. Illinois was the most affected state in 2002, with 884 human cases and 67 deaths due to WNV. In 2006, Illinois reported the sixth highest numbers of human cases (215) and deaths (10) among other US states. WNV can be transmitted from infected birds through mosquito bites. The virus can infect humans and domestic animals. Infections in humans are usually asymptomatic or with mild influenza-like symptoms, such as fever, headache and body aches. Symptoms can be severe in the elderly and, although rarely, can result in encephalitis, meningitis and fatality. The Illinois Public Health Department’s WNV surveillance includes sampling and laboratory testing of mosquitoes and dead wild birds, as well as sick horses and people who fall ill with WNV symptoms. “WNV can cause illness, from mild to severe, and even death in some cases, so people need to remember to wear insect repellent with DEET and protect themselves when outdoors,” said Eric Whitaker, director of Illinois Public Health Department. Toward the end of this year’s WNV season, there have been 906 human cases in the USA and this number could reach 1000 according to experts. California alone has reported 172 cases including six deaths.
Twitter data: What do they represent?

Abstract Scholarly research into the uses of social media has become a major area of growth in recent years, as the adoption of social media for public communication itself has continued apace. While social media platforms provide ready avenues for data access through their Application Programming interfaces, it is increasingly important to think through exactly what these data represent, and what conclusions about the role of social media in society the research which is based on such data therefore enables. This article explores these issues especially for one of the currently leading social media platforms: Twitter.
MRI measurement of brain iron in patients with restless legs syndrome

Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior CSF study. Using a special MRI measurement (R2′), the authors assessed regional brain iron concentrations in 10 subjects (five with RLS, five controls). R2′ was significantly decreased in the substantia nigra, and somewhat less significantly in the putamen, both in proportion to RLS severity. The results show the potential utility of this MRI measurement, and also indicate that brain iron insufficiency may occur in patients with RLS in some brain regions.
Transcriptional Analysis of serk1 and serk3 Coreceptor Mutants1

Transcriptional analysis of serk mutants reveals a novel role of the brassinosteroid coreceptors SERK1 and SERK3 in glucosinolate biosynthesis. Somatic embryogenesis receptor kinases (SERKs) are ligand-binding coreceptors that are able to combine with different ligand-perceiving receptors such as BRASSINOSTEROID INSENSITIVE1 (BRI1) and FLAGELLIN-SENSITIVE2. Phenotypical analysis of serk single mutants is not straightforward because multiple pathways can be affected, while redundancy is observed for a single phenotype. For example, serk1serk3 double mutant roots are insensitive toward brassinosteroids but have a phenotype different from bri1 mutant roots. To decipher these effects, 4-d-old Arabidopsis (Arabidopsis thaliana) roots were studied using microarray analysis. A total of 698 genes, involved in multiple biological processes, were found to be differentially regulated in serk1-3serk3-2 double mutants. About half of these are related to brassinosteroid signaling. The remainder appear to be unlinked to brassinosteroids and related to primary and secondary metabolism. In addition, methionine-derived glucosinolate biosynthesis genes are up-regulated, which was verified by metabolite profiling. The results also show that the gene expression pattern in serk3-2 mutant roots is similar to that of the serk1-3serk3-2 double mutant roots. This confirms the existence of partial redundancy between SERK3 and SERK1 as well as the promoting or repressive activity of a single coreceptor in multiple simultaneously active pathways.
Acceptability of chlamydia screening using self-taken vaginal swabs

In the first phase of the National Chlamydia Screening Programme (NCSP), the majority of sites involved offered testing with urine sample. Camden & Islington (C&l) were the first site to offer testing with self-taken vaginal swabs (SVS). SVS are appropriate specimens for diagnosing chlamydia by nucleic acid amplification tests. This study aimed to assess the uptake and acceptability of chlamydia screening using SVS within C&l contraceptive clinics. Data collected from women participating in the NCSP between June 2003 and April 2004 were analysed. Of the 3936 women who accepted screening, 90.4% provided a SVS and only 5.8% accepted the offer of providing a urine sample as an alternative to SVS. Women over 19 years and women from Asian ethnic groups were most likely to decline any screening. No woman stated a reluctance to provide a SVS as a reason for declining screening, confirming the acceptability of SVS for chlamydia screening.
Energy dissipation in shear driven turbulence.

The Navier-Stokes equations are utilized to derive upper bounds on the turbulent energy dissipation rate for an incompressible Newtonian fluid confined between parallel comoving plates. These estimates provide a rigorous foundation for one of the basic scaling ideas of turbulence theory, namely, the independence of the dissipation rate and the viscosity at high Reynolds number. The bounds are compared to experiments on turbulence in the Couette-Taylor system
Effect of Clenbuterol on Athletic Performance

Unlike inhaled beta 2-agonists, more studies need to be performed before the action of systemic beta 2-agonists on athletic performance can be assessed accurately. Experiments in animals with oral clenbuterol have shown augmentation in muscle bulk across numerous species, but human studies cannot confirm similar muscle mass enlargement in healthy men. Although the human studies demonstrate the potential for long-acting systemic beta 2-agonists to increase muscle strength in certain muscle fiber types, it is difficult to judge the drugs' effects on overall athletic performance, because athletic skill is more than strength, speed, and endurance. The effect of oral clenbuterol on athletic performance cannot be evaluated from its actions on muscle strength alone. However, as evidence stands now, sports regulatory agencies are correct to ban systemic beta 2-agonists until the following 2 points can be proven: (1) oral forms provide a therapeutic benefit that cannot be obtained with aerosol or inhaled forms; and (2) oral forms do not give any unfair advantage to the competitor in muscle strength, power output, or endurance. Provided they are administered as prescribed, aerosol or inhaled beta-agonists do not impart an unfair advantage or enhance athletic performance and can continue to be used in competition by athletes with EIA.
Query by Humming Systems Using Melody Matching Model Based on the Genetic Algorithm

Query by humming (QBH) refers to music information retrieval systems where short audio clips of singing or humming act as queries. Melody is considered as the most important feature in the queries and the songs. This paper proposes a QBH system using melody matching model based on the genetic algorithm and improving the ranking result by local sensitive hashing algorithm. An approximate template of the query music is constructed by melody contour aligning algorithm based on GA, which is used to align and correct the input pitch template. The validity of the algorithm is presented by the prototype of QBH system and effects of the algorithm are also shown by the experiment results. Index Terms—music information retrieval, melody contour representation, audio system
Seven years’ follow-up of comparative study between stenting and medication for treatment of symptomatic vertebrobasilar artery stenosis

Objective Endovascular stent-assistant angioplasty (ESAA) is a valid treatment for symptomatic vertebrobasilar artery stenosis (SVAS), but the long-term effect and the improvement of condition compared with medication treatment are unknown. This study investigated the long-term efficacy of ESAA in patients with moderate and severe SVAS, and compared the efficacy with medication treatment. Materials and methods We conducted a retrospective analysis of clinical data of 43 patients with moderate and severe SVAS hospitalized in our department. According to different treatment methods they were divided into 29 cases in an ESAA group and 14 cases in a medication treatment group. During the follow-up period, the degree of vascular stenosis, vascular blood flow velocity, restenosis rate, recovery of neurological function and the incidence of cerebral ischemic events in the two groups were analyzed. Results The average clinical follow-up period was 89.4 ± 10.2 months. Before treatment, the stenosis rate and average blood flow velocity of the two groups were not statistically significant (p > 0.05). During the follow-up period, both were significantly lower than the medication treatment group (p < 0.01). In the ESAA group, three cases of stent stenosis, and three cases in the medication treatment group were completely occluded. The total ischemic events in ESAA group were three cases, compared with nine cases in the medication treatment group; the difference was statistically significant (p < 0.05). Conclusion ESAA has a long-term effect in the treatment of symptomatic moderate and severe vertebrobasilar artery stenosis. It is superior to medication therapy in preventing posterior circulation ischemia (PCI), but a larger sample size is still needed to confirm the study.