Miracle-dz/UniFAR-FTUs huggingface dataset:
Stem Cells: An Answer to Treat Neurodegeneration?

The demographic studies carried out in India reveal that approximately 10% of the population is over the age of 60. Statistics also reveal that by the year 2021, every seventh person will be a senior citizen. This pattern of ageing poses some serious health issues because with age comes age related disorders. The most pronounced amongst these are the neurodegenerative disorders, which are primarily characterized by neuronal loss /death in the brain or the spinal cord. In the brain, Alzheimer’s disease (AD) and Huntington’s disease (HD) result in loss of neurons, while specific and localized loss of dopaminergic neurons can be seen in Parkinson’s disease (PD). Loss and degeneration of motor neurons in the brainstem and spinal cord is a characteristic feature of Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). In India, approximately 6 million people are living with these disorders. Though it is known that these disorders have neural pathologies, the exact mechanism behind neuronal loss is not yet clearly understood. As a result deciphering efficacious treatment methods for such disorders remains elusive. This lack of treatment methods poses a global burden on the society. Research is extensively carried out to target these diseases at a cellular level. Increasing attention over the past few years has been given to the treatment of neurodegenerative disorders by the use of stem cells. This review will focus mainly on current stem cell research carried out for neurodegenerative diseases, particularly in context to AD, PD, HD and ALS.
Residues of Death

This book provides a critical overview of the changing ways people mourn, commemorate and interact with the remains of the dead, including bodies, materials and digital artefacts. It focuses on how residues of death persist and circulate through different spaces, materials, data and mediated memories, refiguring how the disposal of the dead is understood, enacted and contested across the globe. The volume contains contributions by scholars from a number of disciplines and includes a diverse range of case studies drawn from Asia, Europe and North America. Together they reveal how rapidly changing practices, industries and experiences around death’s remains involve the entwining of digital technologies with other material and ritualised forms of commemoration, as well as with shifting boundaries between the sacred and the profane, the institutional and the vernacular, the public and the private.
A differential equations model of east coast fever transmission dynamics

In this study a differential equation model of the transmission dynamics of East Cost Fever caused by Theileria parva transmitted by Rhippicephalus appendiculatus was developed. In this model cattle were assigned to four categories: susceptible, T. parva incubating, infectious (clinically infected) and recovered cattle population having immunity and still infect ticks but at a lower rate. Ticks were also categorized into various stages: eggs, larvae, susceptible nymphs, infected nymphs, susceptible adult ticks and infected adult ticks. The parameters of the model were obtained from literature assumed or calculated. Simulations with R software were run with and without seasonal questing activity of adult ticks. The results of the simulation model explained the seasonal differences of R. appendiculatus activity and transmission of T. parva between tropical eastern and central Africa and sub – tropical southern Africa. Besides, it showed that nymphs are the stage of R. appendiculatus that play important role in transmission of T. parva in southern Africa while both nymphs and adults transmit in eastern and central Africa. Future developments and data required to further develop the model were proposed. Keywords: A model, Differential equations, Rhipicephalus appendiculatus , Theirelia parva
Cognitive-behavioural therapy for chronic pain

The article presents the basic issues related to cognitive-behavioural therapy and possibility of applying this approach in treatment of patients with chronic pain. Cognitive models of chronic pain and selected therapeutic protocols for patients with chronic pain are described. Adres do korespondencji: dr n. hum. Mariola Skowrońska Szpital Dziecięcy im. prof. dr. med. Jana
Emotional Disorders in Children

The child and adolescent psychopathology have been categorized into two broad classes, emotional (also called internalizing) and behavioral (externalizing) problems (disorders). In this paper, we describe the emotional disorders in children. Emotional disorders signify a core disturbance in intropunitive emotions and mood, namely, sorrow, guilt, fear and worry. These emotional disorders; anxiety disorders, depressive disorders, obsessive-compulsive and related disorders, trauma and stressor-related disorders in childhood and adolescence period will be discussed in more detail.
Role Of Stakeholder Communication In Sustainability of Indonesia's Conservation Area

Indonesia's environmental policy in the conservation area is carried out by establishing the nature reserve as the highest conservation area in addition to wildlife reserves. The high level of damage in the nature reserve area requires collaboration integrated multi-party. Therefore, preservation activities of nature reserves require stakeholder involvement and multi-stakeholder communication in conservation area management. This study aims to: 1) identify the roles and relationships of stakeholders in preserving the nature reserve area 2) formulating a communication model suitable for conservation of the nature reserve. The research method uses survey methods with qualitative and quantitative descriptive approaches obtained from secondary and primary data sources. Data collection techniques carried out by interviews, observation of documentation and questionnaires. The population in this study is the government, business, and society. This research produces two main points, first the party that has the biggest role in the preservation and sustainability of the nature reserve area that is the government. The relationship between government and society shows the pattern of democratic relations with critical partnerships and reciprocal models. The relationship between the government and the business world (Pertamina Geothermal) shows a form of collaboration. The relationship between the community and the business world (Pertamina Geothermal) shows forms of conflict and corporate relations. Second, to synergize communication between stakeholders, we propose a stakeholder communication model for the sustainability of nature reserves that emphasizes partnership, collaborative work, mutual respect, and assertive communication. The more synergy of stakeholder communication, the more effective the preservation of nature reserves.
Towards gene therapy for cystic fibrosis airway disease: development of single-dose lentiviral gene transfer for lifetime airway expression.

x Declaration xii Acknowledgements xiii Publications xvi Scholarships & Awards xviii List of Figures xix List of Tables xxi Glossary of Terms xxii Chapter 1 A Review Of The Literature 01 1.1 Cystic Fibrosis: The Disease 02 1.1.1 A Brief History Of Cystic Fibrosis 02 1.1.2 Clinical Presentation Of Cystic Fibrosis 05 a. Cystic Fibrosis Lung Disease 06 b. Cystic Fibrosis Pancreatic Disease 07 c. Cystic Fibrosis & Other Organs 07 d. Liver Disease 08 e. Infertility 08 f. Cystic Fibrosis Related Diabetes 09 g. Osteopenia & Osteoporosis 10 1.2 Cystic Fibrosis: The Gene 11 1.2. 1 A General Overview 11 1.2. 2 Mutations of CFTR 12 a. Class I Mutation 13
Political Discourse: The Modality in Donald J. Trumph’s Speech in Riyadh Summit 2017

In search of the use of Modality in supporting a political speech and for revealing the tendencies behind it, therefore it examines Donald Trump’s speeches using Types of Modality (Deontic and Epistemic modal) theory and Power, Identification and Manipulation (PIMI) model theory under Critical Discourse Analysis (CDA) approach. The study implements qualitative method consisting of description and the data are reported in words. As the result, Donald J. Trump uses all type of Modality of Deontic modal (permission and obligation) and Epistemic modal (probability/possibility). The aspects of Permission, obligation, and probability or possibility work in showing the idea of power, ideology, and manipulation. The context support Donald J. Trump speech in his Modality expression to promote against Terrorism intervening Middle East conflicts. Furthermore, the researcher is expected that this tool can be implemented in broader analysis and result in political discourse. The researcher also opens for further study that related to this topic in increasing the critical thinking of the readers, and adding more discussion in language and politics. It is also expected in the future that linguistic study can be a tool of transparency in political field especially in Indonesia. Keywords—modality, auxiliary modal, deontic modal, epistemic modal, pimi model, cda, and political discourse.
Antifungal activity of medicinal plant extracts for potential management of Fusarium pathogens

Yield losses due to fungal attacks, post-harvest losses and food spoilage, amongst others present a challenge to food security. There is an ongoing need and search for accessible, affordable and environmentally-friendly alternatives to the use of synthetic pesticides in food production. The aim of this study was to search for affordable potent plant extracts that can be used in smallholder farming system to manage Fusarium related diseases. Extracts from 11 medicinal plant species previously screened against human and animal pathogens in the literature were selected and investigated for their in vitro antifungal activity against five economically important phytopathogenic Fusarium species. Dried leaf powders were extracted with solvents of different polarity and evaluated for antifungal activity using a microdilution method. At least, one of the solvent extracts obtained from a minimum of three plant species demonstrated very strong activity with minimum inhibitory concentration (MIC) less than 0.1 mg/ml against F. equisite, F. oxysporum, F. semitectum, F. chlamydosporum and F. subglutinans. Acetone and ethyl acetate solvent extracts were found in most cases to exhibit stronger antifungal activity compared to water and petroleum ether extracts. However, water extract of Combretum molle was particularly noteworthy as it demonstrated antifungal activity against the tested five Fusarium species. The use of medicinal plant extracts as an antifungal agent presented a cheap, accessible and sustainable source of eco-friendly pesticides useful for crop protection in organic cultivation and small-holder farming.
Students - Future Teachers' Knowledge and Attitudes towards Migrations of Species and Diseases Caused by Insects

The aim of the research was to diagnose the knowledge and attitudes of the students-future teachers, on diseases caused by insects and relationship between migration of people and the spread of diseases. It was assumed that students-future teachers: have a wide range of knowledge about diseases caused by insects; recognize that there is a correlation between the influx of migrants and the threat of the spread of infectious diseases, which were rare so far in European countries or have not been presented at all. Research was carried out with the use of diagnostic survey and the research tool - questionnaire (Thurstone scale). Results of the research showed that 1120 students-future teachers: 504 of Polish and 616 of French universities have a high level of knowledge in the field of infectious diseases (at the level of 62% to 92%). However, 90% of respondents express concern about outbreak of bacterial and viral diseases in connection with the possibility of uncontrolled human migrations. Such students' attitudes can have an effect on the way of transformation of educational contents on migration of different populations and the interaction between them, which should be tested for deeper understanding of teaching contents.
A Usability Evaluation of the Online National Survey for College Graduates (NSCG)

The National Survey for College Graduates (NSCG) is an online data collection Web site that collects education and job information from diverse users who have received bachelor’s degrees from American schools or abroad. In October and November 2009, the Statistical Research Division (SRD) evaluated the usability of the NSCG online survey. The testing evaluated the success and satisfaction of eight participants who attempted to complete the survey developed by the Special Surveys Branch (SSB) of the Demographic Surveys Division (DSD). Usability testing revealed a few usability problems, including illogical placement of survey items and difficulty entering information. This report summarizes the methods and findings of this usability evaluation.
A Review on the Relationship between Social Media Usage, Social Media Sharing, and Depressive Symptoms among University Students

University students were found to have high depressive symptoms, and one of the contributing factors may be social media usage. Multiple studies have found mixed results regarding the relationship between social media usage and depressive symptoms. Some studies found a significant negative relationship between social media usage and depressive symptoms, while several others found an indirect significant relationship or no relationship between these two variables. The difference may be due to other factors such as individuals sharing their positive and negative experiences on social media. Sharing positive experience was found to reduce negative affect (e.g. depression) while sharing negative experience was found to increase negative affect. Therefore, this literature review aims to review these topics, specifically, (1) the relationship between social media usage and depressive symptoms, (2) the relationship between social sharing and depressive symptoms, and (3) to integrate a possible explanation related to the relationship between social media usage, social sharing, and depressive symptoms.
Strategic business units: an exploratory research

This article aims to analyze the management philosophy based on Strategic Business Units (SBU), pointing its origin and confronting the ideas of its main authors. Given the literary scarcity of the subject, the text develops through exploratory research. As a result, General Electric's case will be exposed and commented on, analyzing the difficulties faced by the group in the 60s and pondering how these issues enabled the development of the SBU-based management platform. It then recovers the literature and develops a synoptic reading of the works cited, emphasizing relevant issues that have not yet been developed by science. In conclusion, it is pointed out how this philosophy can contribute to the achievement of perpetuity in modern organizations.
Direct Seamless Transfer Strategy by Limiting Voltage Drop of Interface Filter in Energy Storage Equipment of Microgrid

Microgrids should go into islanding operations to supply power for local critical loads in the event of grid faults. During the operation of the microgrid, the voltage of the point of common coupling (PCC) can be maintained within a certain range by energy storage equipment (ESE). In this article, a direct seamless transfer strategy is developed based on the design of the power and inductor parameters of the three-phase converter in the ESE. When unintentional islanding occurs, the amplitude and frequency of the PCC voltage is affected by the output voltage of the converter, the rated power of the converter, and the voltage drop across the inductor. To ensure the value of the amplitude and frequency of the PCC voltage within the prescribed range, limiters are added to the modulation waves to realize the direct seamless transfer strategy. By analyzing the vector diagram of voltage and current vectors for different loads, the power requirement of the ESE and the voltage drop across the inductor in the converter are obtained. Finally, the design of the limiters’ parameters, analysis of inductor ripple current, and influence of nonlinear load on the PCC voltage are presented for the proposed control strategy.
Safety survey data from Victorian youth-serving organisations: Survey data from workers, young people, and organisational leaders’ self-reflections after implementing the Victorian Child Safe Standards

In 2015, the Victorian Government Department of Health and Human Services (DHHS) introduced the Victorian Child Safe Standards (the Standards). The aim was to promote the safety of children and young people by supporting the way in which organisations, their workforce (staff and volunteers) and members work so that protecting children and young people is always considered, taken seriously and acted upon. These Standards became fully operational in 2017. In 2019 DHHS began a review of the extent to which the Standards promote improvements in the child-safe culture, and the extent to which the regulatory scheme supports compliance by organisations. As part of the review, DHHS commissioned the Australian Catholic University’s Institute of Child Protection Studies (ICPS) to undertake surveys of staff, children, young people and leaders in a variety of youth-serving organisations. This report describes each survey in detail, presents an analysis of the participants, and describes the methodology. We It also presents our findings, addressing each standard individually, with a summary of overall findings related to the Standards as an overall regulatory framework for driving a culture of child-safety within all youth serving organisations across Victoria.
Adesão à Democracia e Apartidarismo na América Latina: Análise Multidimensional

Given the distinct context of the contemporary development of voters’ relationships with political parties in consolidated regimes and new democracies, this article aims to advance in the identification of predictors for democracy support in Latin America. We use hierarchical models that incorporate structural and individual level variables for the explanation of the phenomenon, with emphasis on the profiles of voters who consider their cognitive and political sophistication. Therefore, we constructed models that token into account the apartisanship thesis and the relevance of individual cognitive mobilization, as well as the national experience derived from the democratic legacy. Our results allow us to infer, on the one hand, that the cognitive refinement of the voters is more relevant than the partisanship for the support that they manifest about the different dimension of democracy. On the other hand, the quality and the persistence of the regime have impacts only in some dimensions of democracy.
Polyazolidinammonium as an adjuvant in immunization with lipopolysaccharide of Yersinia pseudotuberculosis

The use of polyazolidinammonium modified with iodine hydrate ions (PAAG) as an adjuvant made it possible to obtain rabbit hyperimmune serums for the pseudotuberculosis microbe lipopolysaccharide (LPS) with specific specificity. The optimal immunizing dose for obtaining hyperimmune pseudotuberculous sera was a dose of 0.25 mg of LPS Yersinia pseudotuberculosis O:3 serovariant per rabbit. When immunizing rabbits with LPS of the pseudotuberculosis microbe, PAAG showed more pronounced adjuvant properties compared to Freund’s complete adjuvant.
Perioperative management of the patient with diabetes requiring emergency surgery

requiring emergency surgery Nicholas Levy, MBBS BSc FRCA FFICM*, Nigel William Penfold, MBBS FRCA, and Ketan Dhatariya, MBBS MSc MD MS FRCP Consultant Anaesthetist, Department of Anaesthesia, West Suffolk NHS Foundation Trust, Hardwick Lane, Bury St Edmunds, Suffolk, IP33 2QZ UK and Consultant Diabetologist, Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, Norfolk, IP33 2QZ UK
MUSLIM MILLENNIAL’S INTENTION OF DONATING FOR CHARITY USING FINTECH PLATFORM

Financial Technology (fintech) has been a part of human life. Fintech becomes a solution of human needs without limits of space and time. Fintech makes it easy for people especially millennials to make donation. This study aims to explore the factors that influence Muslim millennial’s intention in giving donation through fintech. This study uses an integration model of Technology Acceptance Model (TAM) and Theory of Planned Behavior (TPB). Online survey is used in this research including 115 Muslim millennials as sample. Data analized by Structural Equation Model (SEM) using Smart PLS. The results indicate that Perceived Usefulness (PU) and Perceived Ease of Use (PEOU) have no significant effect on Attitude Towards Usage (ATU), Attitude Towards Usage (ATU) has no significant effect on Behavioral Intention (BI), Perceived Usefullness (PU), Subjective Norm (SN) and Perceived Behavioral Control (PBC) significantly have a positive effect on Behavioral Intention (BI). Overall fintech improves Muslim millennial’s intention to make donation easily and almost all of respondents know about fintech, even not all of the use fintech to donate. This research contributes both theoretically and practically.
A phase I/II multi-center study of intravesical nanoparticle albumin-bound rapamycin (ABI-009) in the treatment of BCG refractory non-muscle invasive bladder cancer.

TPS4576 Background: Inactivation of p53 and PTEN mutations promotes progression in bladder cancer via deregulation of the mammalian target of rapamycin signaling pathway (mTOR). mTOR expression increases as a function of the disease stage as it progresses from superficial to invasive bladder cancer. Our group has proven the efficacy of intravesical rapamycin to treat bladder cancer in a mouse model. With the advent of the nanoparticle albumin bound (nab) version of rapamycin (ABI-009), this hydrophobic entity can now be tested intravesically. We sought to investigate the safety and efficacy in the management of Bacillus Calmette-Guerin (BCG) refractory non-muscle invasive urothelial carcinoma of the bladder (NMIBC). Methods: Funded via the NIH small business innovation research program (grants 1R42CA171552 and 3R42CA171552), this combined phase I/II study is currently enrolling patients with BCG refractory NMIBC at Columbia University and Vanderbilt University. BCG refractory is defined as disease recurre.
Stealing Your Android Patterns via Acoustic Signals

Pattern lock is an essential authentication method on mobile devices. Recent works on cracking pattern locks either require additional network facilities (e.g., WiFi hotspots) or suffer from strict constraints (e.g., physical closeness to the victim and good lighting). Being too susceptible to environment settings, these attacks are less effective in practice and cannot scale to a large number of users. To address these concerns, in this paper, we propose PatternListener+, a practical attack on pattern locks using the speakers and microphones on mobile devices. The speaker plays inaudible acoustic signals, which are reflected by the fingertip when the victim is drawing the pattern, and then recorded by the microphone. The recorded acoustic signals contain rich information of the fingertip motion that can be leveraged to infer the pattern. We carefully design a series of algorithms to eliminate the dynamic and static interferences, segment acoustic signals into fragments corresponding to all pattern lines, and recover each line composed of the pattern according to the signals. Finally, we recover the candidate pattern by mapping all line candidates into grid patterns with a tree structure. We implement a PatternListener+ prototype using off-the-shelf smartphones, and extensive experiments confirm the effectiveness and robustness of PatternListener+. The attack success rate is over 90 percent on 120 patterns in five attempts.