Miracle-dz/UniFAR-FTUs huggingface dataset:
Modulation of Cytosolic Protein Kinase C and Calcium Ion Activity by Steroid Hormones in Rat Distal Colon (*)

Studies from our laboratory have demonstrated rapid (<1 min) non-genomic activation of Na-H exchange and potassium recycling by mineralocorticoids in human and rat colonic epithelium. It has previously been demonstrated that Na-H exchange may be stimulated by protein kinase C (PKC) activation; therefore, we examined the effect of mineralocorticoids on PKC activity in rat colonic epithelium. Activation (after 15 min of incubation) of basal PKC activity was observed in cytosolic fractions of rat colonic epithelium by aldosterone, fludrocortisone, and deoxycorticosterone acetate. In all instances, PKC activation was inhibited by the PKC inhibitor bisindolylmaleimide (GF109203X). Hydrocortisone failed to activate PKC activity. Stimulation of basal intracellular free calcium [Ca] was observed, in isolated rat colonic crypts, following aldosterone addition. This stimulatory effect was inhibited by the PKC inhibitor, chelerythrine chloride. Hydrocortisone failed to increase [Ca]. These results indicate that intracellular signaling for aldosterone involves changes in [Ca] via activation of PKC. Since the stimulation of PKC and increase in [Ca] are apparent at normal circulating levels of aldosterone, our findings have major implications for the reassessment of mineralocorticoid effects on electrolyte homeostasis.
Dopamine: so "last century".

The bowels, which had been all along torpid, now in most cases, demand stimulating medicines of very considerable power: the expulsion of the faeces from the rectum sometimes requiring mechanical aid. —James Parkinson, 18171 The cardinal signs of striatal dopamine deficiency (tremor, rigidity, bradykinesia) comprise the foundation for both the diagnosis of Parkinson disease (PD) and for remarkably successful clinical and research efforts into its therapy. Yet, since James Parkinson’s original description of the shaking palsy, it has been clear that PD is not simply a motor disease and its nonmotor symptoms are resistant to the most robust dopaminergic strategies. In this issue of Neurology , Verbaan et al. report a survey of autonomic symptoms in 420 subjects with PD and 150 age- and gender-matched control subjects.2 These subjects are enrolled in the PROfiling PARKinson’s disease (PROPARK) longitudinal observational study of PD, and …
Customer-driven Product Development: A Demand Chain Management perspective

Demand chain management is a research area of increasing attention. It is the undertaking of reacting to customer requirements through a responsive chain going from customers through a focal company towards raw material distributors. With faster growing markets and increasing competition, companies look for new ways to gain competitive advantage. In competitive markets there is a tendency of shorter product life cycles, and thus a competitive factor is to keep at pace with the market or even driving the market by developing new products. This research study seeks to investigate Customer-driven Product Development (CDPD) from a demand chain management perspective. CDPD is the counterpart to typical research and development processes, which has no direct customer involvement. The proposition is that letting customers initiate and participate in the product development process will be a competitive factor by enhancing customer value and strengthening ties to customers, which increases loyalty to the company in competitive markets. CDPD is investigated through an explorative research design in a dyadic case study including a global industrial company and its customers. The study provides an insight into a new area of new product development and demand chain management, including the customer in the case study, which is rare in related research. paper Providing insights into customer demand for new products by increased understanding of the customer-driven product development.
Stakeholder Perspectives on Australia's Greenhouse and Energy Policy

To reduce Australia’s greenhouse gas emissions, the federal government has proposed an emissions trading scheme, known as the Carbon Pollution Reduction Scheme (CPRS), and several ‘complementary’ measures to support efficient energy use, renewable energy and the development of carbon capture and sequestration. Its policies are set out in a White Paper on the CPRS published in 2008, some 2009 revisions on the Department of Climate Change website, and a White Paper on Energy to be published in 2009. This paper examines the potential effectiveness of the government’s greenhouse and energy policies, existing and proposed, in expanding renewable sources of energy, the only set of energy supply technologies that have zero greenhouse gas emissions and are commercially available in Australia. The method is to review overseas experience and then conduct interviews of selected non-government expert stakeholders from academia, business, NGOs and a minor political party. On this basis, additional and improved policies for renewable energy are recommended.
Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths.

BACKGROUND In the National Polyp Study (NPS), colorectal cancer was prevented by colonoscopic removal of adenomatous polyps. We evaluated the long-term effect of colonoscopic polypectomy in a study on mortality from colorectal cancer. METHODS We included in this analysis all patients prospectively referred for initial colonoscopy (between 1980 and 1990) at NPS clinical centers who had polyps (adenomas and nonadenomas). The National Death Index was used to identify deaths and to determine the cause of death; follow-up time was as long as 23 years. Mortality from colorectal cancer among patients with adenomas removed was compared with the expected incidence-based mortality from colorectal cancer in the general population, as estimated from the Surveillance Epidemiology and End Results (SEER) Program, and with the observed mortality from colorectal cancer among patients with nonadenomatous polyps (internal control group). RESULTS Among 2602 patients who had adenomas removed during participation in the study, after a median of 15.8 years, 1246 patients had died from any cause and 12 had died from colorectal cancer. Given an estimated 25.4 expected deaths from colorectal cancer in the general population, the standardized incidence-based mortality ratio was 0.47 (95% confidence interval [CI], 0.26 to 0.80) with colonoscopic polypectomy, suggesting a 53% reduction in mortality. Mortality from colorectal cancer was similar among patients with adenomas and those with nonadenomatous polyps during the first 10 years after polypectomy (relative risk, 1.2; 95% CI, 0.1 to 10.6). CONCLUSIONS These findings support the hypothesis that colonoscopic removal of adenomatous polyps prevents death from colorectal cancer. (Funded by the National Cancer Institute and others.).
Establishing Brand Based Organization by Customer Perspective in Jungleland Adventure Theme Park, Sentul City, Bogor - Indonesia

This research is conducted to formulate the program of Brand-Based Organization at Jungleland Adventure Theme Park. Research is carried out by identifying the visitor perceptions regarding the implementation of brand identity and professionalism implemented by Jungleland’s human resources. This research is also conducted in-depth interview to the management and frontline staffs to get the facts and confirm the findings. In addition, it is to compare with competitors’ brand identity to determine the brand position of Jungleland. The result shows that Jungleland’s brand identity represented by the symbol has the lowest value as perceived by visitors as compared with brand as a product and brand as a person. When Jungleland is compared with its competitors, Trans Studio Bandung, Taman Safari Bogor and Dunia Fantasi, it has the strong point righteously as the later entrant through the attributes of existing brands. Regarding to the results, proposed recommendations for human resources development program towards brand-based organization includes the Talent Management Program and Rewards Management Program.
Effects of indomethacin on central, renal and coronary hemodynamics. An experimental study in swine with unilateral ureteral obstruction.

The circulatory effects of intravenously administered indomethacin, a potent prostaglandin synthesis inhibitor (0.8 mg/kg bw) were investigated in pigs with unilateral ureteral obstruction. The drug induced a marked but transient increase in systemic arterial pressure (+53%, p less than 0.02) and pulmonary arterial (+81%, p less than 0.02) pressure without any changes in left or right sided filling pressures, cardiac output or heart rate. Coronary blood flow remained unchanged and renal venous blood flow decreased (-26%, p less than 0.02). Renal pelvic pressure decreased (-20%, p less than 0.02). Thus systemic (SVR), pulmonary (PVR) and coronary vascular resistance (CVR) and renal vascular resistance (RVR) on the obstructed side increased (SVR + 73%, p less than 0.02; PVR + 140%, p less than 0.02; CVR + 53%, p less than 0.02 and RVR + 107%, p less than 0.02 respectively). Even if one takes into consideration other factors than ureteral obstruction contributing to these reactions, e.g. low volume load, anaesthesia, surgical trauma and species differences, care is advised in treating patients with coronary artery disease or obstructive lung disease with indomethacin.
The inflating curvaton

The primordial curvature perturbation \zeta may be generated by some curvaton field \sigma, which is negligible during inflation and has more or less negligible interactions until it decays. In the current scenario, the curvaton starts to oscillate while its energy density \rho_\sigma is negligible. We explore the opposite scenario, in which \rho_\sigma drives a few e-folds of inflation before the oscillation begins. In this scenario for generating \zeta it is exceptionally easy to solve the \eta problem; one just has to make the curvaton a string axion, with anomaly-mediated susy breaking which may soon be tested at the LHC. The observed spectral index n can be obtained with a potential V\propto \phi^p for the first inflation; p=1 or 2 is allowed by the current uncertainty in n but the improvement in accuracy promised by Planck may rule out p=1. The predictions include (i) running n'\simeq 0.0026 (0.0013) for p=1 (2) that will probably be observed, (ii) non-gaussianity parameter f_NL \sim -1 that may be observed, (iii) tensor fraction r is probably too small to ever observed.
Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells[S]

HDL particles may enter atherosclerotic lesions having an acidic intimal fluid. Therefore, we investigated whether acidic pH would affect their structural and functional properties. For this purpose, HDL2 and HDL3 subfractions were incubated for various periods of time at different pH values ranging from 5.5 to 7.5, after which their protein and lipid compositions, size, structure, and cholesterol efflux capacity were analyzed. Incubation of either subfraction at acidic pH induced unfolding of apolipoproteins, which was followed by release of lipid-poor apoA-I and ensuing fusion of the HDL particles. The acidic pH-modified HDL particles exhibited an enhanced ability to promote cholesterol efflux from cholesterol-laden primary human macrophages. Importantly, treatment of the acidic pH-modified HDL with the mast cell-derived protease chymase completely depleted the newly generated lipid-poor apoA-I, and prevented the acidic pH-dependent increase in cholesterol efflux. The above-found pH-dependent structural and functional changes were stronger in HDL3 than in HDL2. Spontaneous acidic pH-induced remodeling of mature spherical HDL particles increases HDL-induced cholesterol efflux from macrophage foam cells, and therefore may have atheroprotective effects.
EVOLUTION OF MIGRATION UNDER KIN SELECTION AND LOCAL ADAPTATION

Abstract We present here a stochastic two-locus, two-habitat model for the evolution of migration with local adaptation and kin selection. One locus determines the migration rate while the other causes local adaptation. We show that the opposing forces of kin competition and local adaptation can lead to the existence of one or two convergence stable migration rates, notably depending on the recombination rate between the two loci. We show that linkage between migration and local adaptation loci has two antagonist effects: when linkage is tight, cost of local adaptation increases, leading to smaller equilibrium migration rates. However, when linkage is tighter, the population structure at the migration locus tends to be very high because of the indirect selection, and thus equilibrium migration rates increases. This result, qualitatively different from results obtained with other models of migration evolution, indicates that ignoring drift or the detail of the genetic architecture may lead to incorrect conclusions.
Waveform optimization to improve MIMO radar range-angle imaging performance

In this paper, we propose a method combining waveform optimization with radar cross section (RCS) estimation to improve the range-angle imaging performance for multi-input multi-output (MIMO) radar. For each range-angle bin, the transmitting waveforms are optimized by our approach based on the principle of minimizing the mean-square error (MSE), and then the RCS of the associated scatter is estimated with the optimized waveforms. The above process is repeated for each range-angle bin in the target scene. Therefore, all RCSs in the target scene could be estimated more precisely, consequently improving imaging performance. The proposed method takes the advantages of waveform optimization in MIMO radar imaging. Simulations and comparisons with existing methods are conducted, showing the effectiveness and superiority of the proposed approach.
Analysis of genome-wide methylation and gene expression induced by 5-aza-2′-deoxycytidine identifies BCL2L10 as a frequent methylation target in acute myeloid leukemia

Epigenetic changes play a role in the pathogenesis of myeloid malignancies, and hypomethylating agents have shown efficacy in these diseases. We studied the apoptotic effect, genome-wide methylation, and gene expression profiles in HL60 cells following 5-aza-2′-deoxycytidine (decitabine; DAC) treatment, using microarray technologies. Decitabine treatment resulted in a decrease in global DNA methylation, corresponding to 4876 probeset IDs with significantly reduced methylation levels, while the expression of 2583 IDs was modified. The integrated analysis identified 160 genes demethylated and up-regulated by decitabine, mainly including development and differentiation pathway genes. Gene targets of Polycomb group protein regulation were overrepresented in this group. Apoptosis was induced by decitabine, and apoptosis-specific PCR arrays more precisely indicated decitabine-induced up-regulation of 13 apoptosis-related genes, in particular DAP-kinase 1 and BCL2L10. Correspondingly, in primary patient samples, BCL2L10 was hypermethylated in 45% of AML, 43% of therapy-related myeloid neoplasms, 12% of MDS, and in none of the controls. In conclusion, decitabine induces global demethylation and gene expression, in particular of Polycomb target genes involved in development and differentiation pathways. The apoptotic gene BCL2L10 is a frequent target for aberrant promoter methylation in patients with acute leukemia, de novo and therapy-related.
ASPECTS OF ORGANIZATIONAL AMBIDEXTERITY

The ability of an organization to be flexible and adaptive to change by exploring new opportunities while at the same time being effective and aligned with daily operations through exploiting current capabilities is defined as organizational ambidexterity. Achieving organizational ambidexterity is not trivial, and in this study at least three solutions are presented in order to support it (structural, temporal and contextual). Also, a review is conducted regarding the context of organizational ambidexterity in the framework of organizational learning, resource management, technology management and organizational behavior as well as about the factors affecting it.
Unrelated cord blood compared with haploidentical grafts in patients with hematological malignancies

Alternative donors, such as unrelated umbilical cord blood (UCB) and related haploidentical (haplo) donors, are more and more frequently searched for and used for patients who are candidates for allogeneic hematopoietic stem cell transplantation but are without a suitable related or unrelated donor. The aim of the current retrospective study was to compare the outcome of patients after haplo and UCB grafts prepared using a nonmyeloablative conditioning regimen.
On the Critical Role of Divergent Selection in Evolvability

An ambitious goal in evolutionary robotics is to evolve increasingly complex robotic behaviors with minimal human design effort. Reaching this goal requires evolutionary algorithms that can unlock from genetic encodings their latent potential for evolvability. One issue clouding this goal is conceptual confusion about evolvability, which often obscures the aspects of evolvability that are important or desirable. The danger from such confusion is that it may establish unrealistic goals for evolvability that prove unproductive in practice. An important issue separate from conceptual confusion is the common misalignment between selection and evolvability in evolutionary robotics. While more expressive encodings can represent higher-level adaptations (e.g. sexual reproduction or developmental systems) that increase long-term evolutionary potential (i.e. evolvability), realizing such potential requires gradients of fitness and evolvability to align. In other words, selection is often a critical factor limiting increasing evolvability. Thus, drawing from a series of recent papers, this article seeks to both (1) clarify and focus the ways in which the term evolvability is used within artificial evolution, and (2) argue for the importance of one type of selection, i.e. divergent selection, for enabling evolvability. The main argument is that there is a fundamental connection between divergent selection and evolvability (on both the individual and population level) that does not hold for typical goal-oriented selection. The conclusion is that selection pressure plays a critical role in realizing the potential for evolvability, and that divergent selection in particular provides a principled mechanism for encouraging evolvability in artificial evolution.
Leader progression model application for calculation of lightning critical flashover voltage of overhead transmission line insulators

The paper presents a method for calculation of lightning critical flashover voltage (CFO) of overhead transmission insulators. The method is based on the application of leader progression model (LPM). CFO was calculated and measured in high voltage laboratory for different polymer and glass insulator strings equipped with arcing horns and grading rings fittings. Comparison of laboratory measurements and calculation results showed that CFO can be determined with good accuracy by using the presented method.
THE FIXATION OF CARBON DIOXIDE BY GROWING AND NONGROWING YEAST

Although studies with labeled carbon have revealed that C02 is an active participant in the complex pattern of intermediate metabolism (Werkman and Wood, 1942; Buchanan and Hastings, 1946; Wood, 1946), little information is available concerning the dynamics of C02 metabolism in the living organism. The available evidence indicates that the degree to which C02 is incorporated into the cellular components of an organism depends, among other things, upon whether the organism is resting (nongrowing) or in an active state of protein synthesis (growing). Thus, experiments with rats (Bloom et al., 1947; Schubert and Armstrong, 1949) and mice (Brues and Naranjo, 1949; Skipper et al., 1949) have shown that growing cells tend to fix and retain CO2 carbon to a greater extent than do nongrowing cells. Microorganisms are particularly suitable for a study of this nature since such cells can be grown from almost zero mass to "adult size" under well-defined conditions. In the present investigation, a comparison is made between the rate of uptake of labeled C02 by yeast cells undergoing rapid proliferation in an atmosphere containing labeled C02 and nongrowing cells under the same conditions. Data are also presented that describe the manner in which changes in the concentration of the environmental C02 influence the fixation of C02 by growing yeast cells.
Multilingual Wordnet sense Ranking using nearest context

In this paper, we combine methods to estimate sense rankings from raw text with recent work on word embeddings to provide sense ranking estimates for the entries in the Open Multilingual WordNet (OMW). The existing Word2Vec pre-trained models from Polygot2 are only built for single word entries, we, therefore, re-train them with multiword expressions from the wordnets, so that multiword expressions can also be ranked. Thus this trained model gives embeddings for both single words and multiwords. The resulting lexicon gives a WSD baseline for five languages. The results are evaluated for Semcor sense corpora for 5 languages using Word2Vec and Glove models. The Glove model achieves an average accuracy of 0.47 and Word2Vec achieves 0.31 for languages such as English, Italian, Indonesian, Chinese and Japanese. The experimentation on OMW sense ranking proves that the rank correlation is generally similar to the human ranking. Hence distributional semantics can aid in Wordnet Sense Ranking.
Meningeal exudate cells in vaccinia meningitis of mice: role of local T cells

Intracerebral inoculation of vaccinia virus into adult DDD mice produced intensive meningitis several days after infection. The inflammatory reaction could be quantitated by counting cells obtained from this inflammatory lesion. The local virus titer increased until day 5 and subsequently decreased rapidly with time. Concomitant with this titer decrease, numerous meningeal exudate cells appeared in the lesion. The cytotoxic activity of these cells against vaccinia virus infected cells was studied after removal of glass-adherent cells. The results showed that these meningeal exudate cells possessed cytotoxic activity against the virus-infected cells and moreover inhibited plaque formation by vaccinia virus. The magnitude of this activity was much larger than that of spleen cells obtained from the same animals. After treatment with antithymocyte serum, or with antitheta serum plus complement, the meningeal cells lost their inhibitory activity, suggesting that the cells which exerted the effect were mainly T lymphocytes. The meningeal exudate cells obtained on day 7 postinfection were further characterized. A greater part, approximately 80%, of the cell population was composed of theta-positive cells. Less than 1% carried immunoglobulin, 7% possessed neither theta antigen nor immunoglobulin on the surface, and 12% represented glass-adherent cells.
AN OPTIMUM SERVICE BROKER POLICY FOR SELECTING DATA CENTER IN CLOUDANALYST

Routing request to proper destination is a key consideration in distribution networks. Service broker policy is the essential logic, which functions with this intention. Choosing the right data center is the promising task for service broker policy. The simulation tool CloudAnalyst contains few service broker policies with which request is routed to the appropriate destination data center. Random selection of data center in these service broker policies deteriorates the efficiency of response time parameter. In this paper, a new service broker policy is proposed which optimally routes the request to a data center and overcomes the issues raised by random selection of a data center.