Miracle-dz/UniFAR-FTUs huggingface dataset:
Is This the Right Drug or the Dose for the Management of Onychomycosis

Onychomycosis is a fungal infection of the toenails and fingernails that results in thickening, discoloration, splitting as well as lifting of the nails from the nail bed. It affects 14% of the total world population, with more prevalence in elders and diabetics. Both dermatophytes (Trichophyton rubrum or T. mentagrophytes) and nondermatophytes (Scopulariopsis brevicaulis, Aspergillus spp, Fusarium spp, and sometimes Candida spp) have been identified as etiologic agents of onychomycosis. The treatment of onychomycosis is known to be challenging since it is a chronic condition, difficult to eradicate and tends to relapse [1]. The pharmacotherapy of onychomycosis involves prolonged systemic or oral antifungal therapy due to slow overturn rate of nail as well as limited blood circulation into the affected nail bed. However, complete cure that involves a clinical cure (normal nail morphology) and mycological cure (both negative microscopy and dermatophyte culture), is often unattainable. In recent years the development of antifungal drugs of second generation (fluconazole, itraconazole, and terbinafine) has produced notable, long-term cure rates with shorter treatment period and improved safety profiles as compared to the first generation antifungal agents. However, different dosage regimens of various antifungal agents have been used by various researchers in clinical trials in order to ensure the complete eradication of the fungal infection in a shorter period with better efficacy.
Use of CouchDB for Document-based Storage of DICOM Objects1

Picture archiving and communication systems traditionally have depended on schema-based Structured Query Language (SQL) databases for imaging data management. To optimize database size and performance, many such systems store a reduced set of Digital Imaging and Communications in Medicine (DICOM) metadata, discarding informational content that might be needed in the future. As an alternative to traditional database systems, document-based key-value stores recently have gained popularity. These systems store documents containing key-value pairs that facilitate data searches without predefined schemas. Document-based key-value stores are especially suited to archive DICOM objects because DICOM metadata are highly heterogeneous collections of tag-value pairs conveying specific information about imaging modalities, acquisition protocols, and vendor-supported postprocessing options. The authors used an open-source document-based database management system (Apache CouchDB) to create and test two such databases; CouchDB was selected for its overall ease of use, capability for managing attachments, and reliance on HTTP and Representational State Transfer standards for accessing and retrieving data. A large database was created first in which the DICOM metadata from 5880 anonymized magnetic resonance imaging studies (1,949,753 images) were loaded by using a Ruby script. To provide the usual DICOM query functionality, several predefined “views” (standard queries) were created by using JavaScript. For performance comparison, the same queries were executed in both the CouchDB database and a SQL-based DICOM archive. The capabilities of CouchDB for attachment management and database replication were separately assessed in tests of a similar, smaller database. Results showed that CouchDB allowed efficient storage and interrogation of all DICOM objects; with the use of information retrieval algorithms such as map-reduce, all the DICOM metadata stored in the large database were searchable with only a minimal increase in retrieval time over that with the traditional database management system. Results also indicated possible uses for document-based databases in data mining applications such as dose monitoring, quality assurance, and protocol optimization.
O ct 2 01 7 Mean-payoff Games with Partial Observation ∗

Mean-payoff games are important quantitative models for open reactive systems. They have been widely studied as games of full observation. In this paper we investigate the algorithmic properties of several sub-classes of mean-payoff games where the players have asymmetric information about the state of the game. These games are in general undecidable and not determined according to the classical definition. We show that such games are determined under a more general notion of winning strategy. We also consider mean-payoff games where the winner can be determined by the winner of a finite cycleforming game. This yields several decidable classes of mean-payoff games of asymmetric information that require only finite-memory strategies, including a generalization of full-observation games where positional strategies are sufficient. We give an exponential time algorithm for determining the winner of the latter.
Divorce, dispersal and incest avoidance in the cooperatively breeding superb fairy-wren Malurus cyaneus

1. Between 1988 and 2001, we studied social relationships in the superb fairy-wren Malurus cyaneus (Latham), a cooperative breeder with male helpers in which extra-group fertilizations are more common than within-pair fertilizations. 2. Unlike other fairy-wren species, females never bred on their natal territory. First-year females dispersed either directly from their natal territory to a breeding vacancy or to a foreign 'staging-post' territory where they spent their first winter as a subordinate. Females dispersing to a foreign territory settled in larger groups. Females on foreign territories inherited the territory if the dominant female died, and were sometimes able to split the territory into two by pairing with a helper male. However, most dispersed again to obtain a vacancy. 3. Females dispersing from a staging post usually gained a neighbouring vacancy, but females gaining a vacancy directly from their natal territory travelled further, perhaps to avoid pairing or mating with related males. 4. Females frequently divorced their partner, although the majority of relationships were terminated by the death of one of the pair. If death did not intervene, one-third of pairings were terminated by female-initiated divorce within 1000 days. 5. Three divorce syndromes were recognized. First, females that failed to obtain a preferred territory moved to territories with more helpers. Secondly, females that became paired to their sons when their partner died usually divorced away from them. Thirdly, females that have been in a long relationship divorce once a son has gained the senior helper position. 6. Dispersal to avoid pairing with sons is consistent with incest avoidance. However, there may be two additional benefits. Mothers do not mate with their sons, so dispersal by the mother liberates her sons to compete for within-group matings. Further, divorcing once their son has become a breeder or a senior helper allows the female to start sons in a queue for dominance on another territory. Females that do not take this option face constraints on their ability to recruit more sons into the local neighbourhood.
Mutants Is Associated with Asymmetric Dimerization Derived EGF Receptor − Cetuximab Response of Lung Cancer

Kinase domainmutations of the EGF receptor (EGFR) are common oncogenic events in lung adenocarcinoma. Here, we explore the dependency upon asymmetric dimerization of the kinase domain for activation of lung cancer–derived EGFR mutants. We show that whereas wild-type EGFR and the L858R mutant require dimerization for activation and oncogenic transformation, the exon 19 deletion, exon 20 insertion, and L858R/T790M EGFRmutants do not require dimerization. In addition, treatment with the monoclonal antibody, cetuximab, shrinks mouse lung tumors induced by the dimerization-dependent L858R mutant, but exerts only a modest effect on tumors driven by dimerization-independent EGFR mutants. These data imply that different EGFR mutants show differential requirements for dimerization and that disruption of dimerization may be among the antitumor mechanisms of cetuximab. Cancer Res; 73(22); 6770–9. 2013 AACR.
Oxygen and hydrogen ion abundance in the near-Earth magnetosphere: Statistical results on the response to the geomagnetic and solar wind activity conditions: OXYGEN ABUNDANCE IN THE MAGNETOSPHERE

The composition of ions plays a crucial role for the fundamental plasma properties in the terrestrial magnetosphere. We investigate the oxygen-to-hydrogen ratio in the near-Earth magnetosphere from -10 RE 274 keV O+ ion intensities, relative to the corresponding hydrogen intensities; (3) In contrast to ~10 keV ions, the >274 keV O+ ions show the strongest acceleration during growth phase and not during the expansion phase itself. This suggests a connection between the energy input to the magnetosphere and the effective energization of energetic ions during growth phase; (4) The ratio between quiet and disturbed times for the intensities of ion ionospheric outflow is similar to those observed in the near-Earth magnetosphere at >274 keV. Therefore, the increase of the energetic ion intensity during disturbed time is more likely due to the intensification than to the more effective acceleration of the ionospheric source. In conclusion, the energization process in the near-Earth magnetosphere is mass dependent and it is more effective for the heavier ions.
The Safety of Direct Oral Anticoagulants with P2Y12 Inhibitors: A Systematic Review and Meta-Analysis of Clinical Trials

Dr. Mo is Associate Professor of Pharmacy Practice at the Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University Pharmacy in Brooklyn, New York; Dr. Yeh is Manager, Global Health Economics at Amgen Inc. in Thousand Oaks, California. At the time of this study, he was Assistant Professor at Long Island University. Dr. Yam is Associate Clinical Professor at the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences in La Jolla, California. Disclosure: The authors report no financial or commercial interest in regard to this article.
Software-Engi neeri ng Process ( SEPS )

This article describes the Software-Engineering Process Simulation (SEPS) model developed at JPL. SEPS is a dynamic simulation model of the software project-development process. It uses the feedback principles of system dynamics to simulate the dynamic interactions among various software lifecycle development activities and management decision-making processes. The model is designed to be a planning tool to examine trade-offs of cost, schedule, and functionality, and to test the implications of different managerial policies on a project’s outcome. Furthermore, SEPS will enable software managers to gain a better understanding of the dynamics of software project development and perform postmortem assessments.
Semantic Matching Using Ontology in Multilingual Environment

The tremendous increase in usage of data over the past few years and the ease of availability of things across the globe any time lead to the Advancement of multilingual database. Storage, retrieval and archiving of data for multi lingual system has been a challenge. Our research project “Semantic Matching using Ontology in Multilingual Environment” is an extension is to look into addressing multi-lingual data. The report focuses on providing design and implementation of multilingual system. These comprise of two main components being (i) Cross Lingual Information Retrieval, and (ii) Indian Language to Indian Language Machine Translation. Consider the context of large scale natural language processing applications in the areas of Cross Lingual IR and Machine Translation, wherein such a model for multilingual dictionary is established. When contrasted to traditional single lingual or bilingual dictionary, the model uses the core concept of Synonym Groupings (synsets) that is used as a way to connect different languages in a crisp and efficient manner.
LES of turbulent channel flow and heavy particle dispersion

The Eulerian-Lagrangian approach has been applied to two-phase turbulent flows with dispersed heavy particles. First, numerical computations of the continuous phase (fluid) have been performed using the Direct Numerical Simulations (DNS) and Large-Eddy Simulations (LES) for the case of a fully-developed channel flow. Parallelisation efficiency of flow and particle solvers has been estimated. Residual turbulent kinetic energy has been found from filtered DNS (also called a priori LES); a model for this quantity has been assessed. Then, heavy particles have been tracked in the LES velocity field. Statistics of particle motion (mean velocity, intensity of velocity fluctuations) and the profile of cross-stream number density as well as preliminary results for particle wall deposition have been obtained.
Le syndrome de Bardet-Biedl Bardet-Biedl syndrome

Bardet-Biedl syndrome (BBS) is a ciliopathy causing multivisceral abnormalities. Its prevalence in Europe is from 1/125,000 to 1/175,000. This disorder is defined by a combination of clinical signs: obesity, pigmentary retinopathy, post-axial polydactyly, polycystic kidneys, hypogenitalism, and learning disabilities, many of which appearing after several years of evolution. Individual clinical phenotype is highly variable. Most signs are present in a majority of patients but only pigmentary retinopathy is constant after infancy. There are many other associated minor clinical signs including diabetes, blood hypertension, congenital cardiopathy or Hirschsprung disease. This broad clinical spectrum is associated to a great genetic heterogeneity, with mainly an autosomal recessive transmission and, sometimes cases of oligogenism. To date, mutations in 12 different genes (BBS1 to BBS12) are responsible for this phenotype. These genes code for proteins involved in the development and function of primary cilia. Absent or non functional BBS proteins affect cilia in certain organs such as kidney or eye. However, some symptoms are still not clearly related to cilia dysfunction. BB syndrome has to be recognized because a molecular diagnosis is possible and will lead to familial genetic counseling and possibly prenatal diagnosis. Patients with BBS will need a multidisciplinary medical care. The renal abnormalities are the main life-threatening features because they can lead to end-stage renal failure and renal transplantation. Retinal dystrophy leading to progressive vision loss, moderate mental retardation, and obesity will affect social life of these patients. © 2008 Elsevier Masson SAS. Tous droits réservés.
Concerns about the microbiological quality of traditional raw milk cheeses: a worldwide issue

Six types of unripened raw milk fresh (Robiola, Crescenza, Primo sale and Formaggella) and “pasta filata” cheeses (Mozzarella and Burrata) were evaluated for microbiological parameters. No Listeria monocytogenes or Salmonella spp. were detected, but high microbial counts were revealed. Significantly higher Total Viable Counts (TVC) and Enterobacteriaceae counts were observed in “fresh cheese” than in “pasta filata” samples. Values > 6 Log CFU/g were found in 81.3% of fresh vs 50% in pasta filata for TVC and 65.6% vs 12.5% for Enterobacteriaceae, respectively. An evident contamination by Escherichia coli , Coagulase-positive Staphylococci and Pseudomonas spp. was detected in all the cheeses: the causes could be the improper hygiene of the artisanal production practices and the permanence of the cheeses on the refrigerated shelves. A careful attention to the respect of the good manufacturing practices is suggested to avoid the presence of initial high bacterial loads.
Introduction: equality and diversity in 14 countries – analysis and summary

the first edition of the International Handbook on Diversity Management at Work (klarsfeld, 2010a) considered the practice of diversity management within the national contexts of 16 countries – austria, belgium, canada, France, germany, India, Italy, the netherlands, Pakistan, singapore, south africa, sweden, switzerland, turkey, the Uk and the Usa. this second edition provides updates on some of the original country selections and supplements these with a further series of countryspecific overviews. new to this edition are australia, Finland, Japan, new Zealand, nigeria and russia. countries that have been updated and expanded are austria, canada, France, India, Italy, the netherlands, south africa and the Uk. Historically, human resource management, when dealing with issues of equality and diversity, was concerned with the disparate activities of dealing with equity issues in pay systems, statutory employment regulation in relation to discrimination and of managing crosscultural diversity when expatriate managers were sent to work overseas. one of the most significant effects of globalization has been a shift in the scope of diversity management into a much more interdependent and wideranging concept. the dynamics of labour markets around the world have led to far greater diversity of workforces and have therefore expanded the challenges to human resource managers in dealing with the consequences of these changes (verma and He, 2010). as the demographic profile of workers becomes more diverse in terms of age, gender, race and ethnicity, nationality, disability and other dimensions of diversity, human resource scholars and practitioners must now contend with managing intranational diversity within the workforce. owing to these conditions of superdiversity (vertovec, 2007) longstanding modes of national diversity are subjected to new and varied migration flows and increasing complex social formations marked by the dynamic interplay of different variables. the above shifts have also elevated the significance of diversity management in some countries discussed in this edition, such as canada, south africa and the Uk, from a functional to a strategic level on corporate and government agendas. It is important to study issues of diversity from a national perspective for several reasons. antidiscrimination legislation which regulates the treatment of disadvantaged groups differs from country to country and the dynamics of equality and diversity vary according to national historical circumstances (for instance, the nature and extent of postcolonial legacy). For example, employers in australia, canada, new Zealand, south africa and the Uk are required to collect data and monitor the progress of racial minority employees in the workforce in order to enhance equality, but the practice of collecting ‘ethnic’ data by employers is explicitly forbidden in France and many european Union (eU) countries – also in the name of equality – making it difficult to track the progress
Investigating naming convention adherence in Java references Conference or Workshop Item

Naming conventions can help the readability and comprehension of code, and thus the onboarding of new developers. Conventions also provide cues that help developers and tools extract information from identifier names to support software maintenance. Tools exist to automatically check naming conventions but they are often limited to simple checks, e.g. regarding typography. The adherence to more elaborate conventions, such as the use of noun and verbal phrases in names, is not checked. We present NOMINAL, a naming convention checking library for Java that allows the declarative specification of conventions regarding typography and the use of abbreviations and phrases. To test NOMINAL, and to investigate the extent to which developers follow conventions, we extract 3.5 million reference — field, formal argument and local variable — name declarations from 60 FLOSS projects and determine their adherence to two wellknown Java naming convention guidelines that give developers scope to choose a variety of forms of name, and sometimes offer conflicting advice. We found developers largely follow naming conventions, but adherence to specific conventions varies widely.
Segment-Elevation Myocardial Infarction Patient − − Assisted Beating of the Ischemic Heart : How to Manage the Pulseless

Segment-Elevation Myocardial Infarction Patient −− Assisted Beating of the Ischemic Heart: How to Manage the Pulseless ST Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2014 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.114. 00927
FABRICATION AND IN- VITRO PERMEATION STUDIES OF INDOMETHACIN- FICUS CARICA FRUIT MUCILAGE PATCHES

The main objective of the present study was to develop matrix-moderated transdermal systems of Indomethacin using various proportions of Ficus carica fruit mucilage. Physical evaluation was performed such as moisture content, moisture uptake, tensile strength, flatness and folding endurance. In-vitro permeation studies were performed in a Keshary-Chien diffusion cell. The matrix-type transdermal systems were prepared using Indomethacin with Ficus carica fruit mucilage by the solvent evaporation technique. The interactions between Indomethacin and Ficus carica fruit mucilage were performed. The transdermal patches were subjected to various physicochemical parameters viz., mechanical properties, permeation studies and skin irritation studies. The prepared patches possessed satisfactory pre-formulary and formulary characteristics. In vitro permeation studies were performed using a Keshary-Chien diffusion cell across hairless Albino rat skin. The non-ionic surfactants Span 80, Glycerin, Propylene glycol in the formulation played a role as permeability enhancer. The patches were seemingly free of potentially hazardous skin irritation. The experimental results shows that the release of drug from the patch delayed in controlled manner as the proportion of Ficus carica increased. It was concluded that Indomethacin can be developed as a transdermal patches with Ficus carica fruit mucilage
Comparative study of saxophone multiphonic tones. A possible perceptual categorization

A number of studies have been devoted to the produc tion of multiphonics in woodwinds, focusing on the possibil ities and difficulties of intonation, fingering, pitch of com ponents, and production of trills [1, 2]. However, most of them disregard the timbric and dynamic qualities of these tones, or ar e aimed to the detailed analysis of a few multiphonic examples. Re cent research also served to unveil the physical princip les that give rise to these complex tones [3], including the inte raction with the vocal tract of the performer [4]. In comparison , the psychophyisics of the multiphonic perception have r eceived much less attention, and a complete picture of how these multiple sonorities are eventually grouped into per ceptual classes is still missing.
of Career Complexity and Career Patterns Over Time Do Economic Globalization and Industry Growth Destabilize Careers ? An Analysis

We analyze the impact of economic globalization and industry growth on the complexity of early work careers in Germany. We conceptualize complexity as the absolute number of employer changes, the regularity in the order of job changes, and the variability of the durations spent in different employment states. Results from empirical analyses based on the German Life History Study (N = 5453) show only a small increase in the complexity of work careers over the last decades, but there was a shift in the prevalence of different career patterns. This suggests that effects of globalization might be counteracted or modified by other social changes that affected work careers in Germany during the last 60 years. In particular, we consider the possible impact of educational expansion, labor market restructuring, and women’s increased employment. We find no evidence that industry-specific economic globalization impacts the complexity of work careers, but we find a U-shaped relationship between industry growth and career complexity. Careers are slightly more complex in industries with high or low industry growth. We conclude that, while there has been a shift in career patterns over time, the impact of globalization on career stability is possibly overestimated.