Miracle-dz/UniFAR-FTUs huggingface dataset:
Cloning and sequence analysis of b-tubulin gene of Trypanosoma evansi isolates from Indian dromedaries (Camelus dromedarius)

Trypanosomosis caused by Trypanosoma evansi is a disease of economic significance of domestic livestock, causing trypanosomiasis, commonly known as Surra. In the present study, gene of Trypanosoma evansi have beer cloned and sequenced. Beta-tubulin is important for cellular structure and physical functions. Sequence analysis of this gene will be useful for the vaccine studies. The open reading frame of b-tubulin of Trypanosoma evansi is 1329 bp in length, encoding 442 amino acid polypeptide. The sequence analysis revealed that the s tubulin gene of Trypanosoma evansi from India was having the identity of 99% with T.equiperdum, T.evansi (China isolate), T.evansi (Indian isolates), T.brucei and 88% with T.cruzi. The stable biological characteristics of Trypanosomatidae beta-tubulin make it an ideal target of many anti-parasitic drugs that block tubulin function.
The Study of Various Control Techniques and Configurations for Grid Connected Photovoltaic DC/AC Converter

The fossil fuels are unable to meet energy demand thus requirement of the grid connected photovoltaic system arises which increases the importance the DC/AC converters. Hence the study of control strategies employed on it needs to be studied to enhance performance and efficiency. This paper discuss about different topologies, international grid standard, power processing stages in system, MPPT, challenges and the control strategies for converter. A review is done on control strategies for converter (AC and DC side). Also a comparative analysis is done between different strategies.
Predicting Code Context Models for Software Development Tasks

Code context models consist of source code elements and their relations relevant to a development task. Prior research showed that making code context models explicit in software tools can benefit software development practices, e.g., code navigation and searching. However, little focus has been put on how to proactively form code context models. In this paper, we explore the proactive formation of code context models based on the topological patterns of code elements from interaction histories for a project. Specifically, we first learn abstract topological patterns based on the stereotype roles of code elements, rather than on specific code elements; we then leverage the learned patterns to predict the code context models for a given task by graph pattern matching. To determine the effectiveness of this approach, we applied the approach to interaction histories stored for the Eclipse Mylyn open source project. We found that our approach achieves maximum F-measures of 0.67, 0.33 and 0.21 for 1-step, 2-step and 3-step predictions, respectively. The most similar approach to ours is Suade, which supports 1-step prediction only. In comparison to this existing work, our approach predicts code context models with significantly higher F-measure (0.57 over 0.23 on average). The results demonstrate the value of integrating historical and structural approaches to form more accurate code context models.CCS CONCEPTS • Software and its engineering → Development frameworks and environments; • Human-centered computing → Human computer interaction (HCI).
Marketing and Promotion of E-resources

In the digital era, e-resources are becoming part of global literature. Hence, libraries cannot collect only printed materials. As for libraries, they need to do collaborative efforts in resources sharing at national and international level to gain wider access to e-resources at reasonable cost. As for library professionals, they should participate in marketing process to attract more users, trying to fulfill necessities in budget, ICT and marketing skills. The purpose of this paper is to review literature on marketing regarding budget allocation, ICT skills, marketing skills and to identify marketing tools/techniques for e-resources. It cannot be definitively stated that budget allocation, ICT skills and marketing skills will be challenges in every institution to conduct marketing. However, the results provide a basis for libraries to consider marketing and necessities in marketing. This paper also provides a useful overview of marketing and promotion of e-resources and awareness of necessities in budget allocation, ICT skills, and marketing skills for both working librarians and future librarians. It presents marketing tools/techniques for e-resources as well.
Identification of Trustworthy Sellers and Buyers in E-commerce

:Shopping through e-commerce websites has become an integral part of our routine and it is all but impossible to imagine a world without this. The success of these marketplaces is attributed not only to the ease that the buyers can have number of options available on a single click, but also to the fact of lesser time consumption. In spite of its cost effectiveness, e-commerce lacks the personal contact with the vendor. Hence for many people this rise of ecommerce was a surprise. How is it that strangers, who may be thousands of miles apart, are willing to trust each other? So the trust is undeniably the most critical factor when customers try to select proper e-commerce sellers for performing transactions online. At the same time Trustworthiness evaluation can‟t be assessed directly using some pre-defined metrics. It has to be perceived from various parameters including past history, reputation, website quality, and seller's response and customer support. However, these decisions are mainly dependent on the reviews that are posted by the post purchase user. In this paper, we have an approach for evaluating the feedbacks that can act as a decision support system, which can aid users to measure the trustworthiness of the user‟s opinion about a product or a service. In fact, the main part of the architecture lies in an intelligent layer that proposes three point questions from a collection of prefabricated feedbacks about the targeted product to each user who wants to provide his/her opinion. As a result of the user‟s selection, the proposed reputation algorithm generates better trust degree of the user, trust score of the feedback, global reputation score of the product and trustworthiness of the sellers.
Importance of tribology in food and dairy industries: An overview

A safe, reliable and inexpensive energy supply is at the centre of any laudable economic growth and development. Being an agriculturally dominant nation, the strength of India’s bio-energy programs mostly lies in the agricultural sector generating over 500 million tons of biomass in the form of crop residues every year. In Punjab state which produces about 19% of wheat and 11% of rice of the country, the disposal of agro residue in the beneficial way along with its pollution is a very serious problem. Therefore, the study synthesized and evaluated the energy potential for the power sector from the available crop residue in the state. It was estimated that of the total crop residues generated in the state (48.2 million tons), the surplus residue about 16.9 million tons (35% of the total generation) belonged to cereals (94.1%). The highest residue generated per unit of area was from sunflower (7.88 t ha-1). It was estimated that the surplus crop residue has a potential to generate about 77.3 MW of bio energy annually in which the contribution of wheat and paddy is maximum due to higher area under these crops in the state during their respective rabi and kharif seasons. The crop wastes are capable to meet about 28652 Joules capita-1 energy requirements per annum. Against the potential for power generation at 3472 MW, there exists an installed capacity of only 317.10 MW for total biomass forming about 23% of the total power generating capacity in the state. Majority of the installed capacity in the state comes from thermal sources (60.6%) followed by hydro (28.4%) and nuclear (1.5%) and renewable sources form only 9.5% of the total installed capacity. Thus biomass energy, from crop residues available in plenty in the state, can be used as substitute to fulfill the additional energy requirements and reduce dependency on fossil fuels.
Adaptively Secure Functional Encryption for Inner-Product Values

: Functional encryption for inner-product values was (cid:12)rst introduced by Abdalla et al. (PKC 2015), where decrypting a chipertext for a vector ⃗x with a secret key for a vector ⃗y reveals only the inner-product value of these vectors ⃗x (cid:1) ⃗y . We call it inner-product value encryption (IPVE) in contrast to inner-product predicate encryption (IPPE), which is usually called inner-product encryption (IPE). To the best of our knowledge, while there already exist a selectively secure IPVE scheme and an adaptively secure one in the secret-key setting, there is no adaptively secure one in the public-key setting. We present the (cid:12)rst IPVE scheme that is adaptively secure in the public-key setting under the decisional linear (DLIN) assumption.
Climate oscillation and the invasion of alien species influence the oceanic distribution of seabirds

Abstract Spatial and temporal distribution of seabird transiting and foraging at sea is an important consideration for marine conservation planning. Using at‐sea observations of seabirds (n = 317), collected during the breeding season from 2012 to 2016, we built boosted regression tree (BRT) models to identify relationships between numerically dominant seabird species (red‐footed booby, brown noddy, white tern, and wedge‐tailed shearwater), geomorphology, oceanographic variability, and climate oscillation in the Chagos Archipelago. We documented positive relationships between red‐footed booby and wedge‐tailed shearwater abundance with the strength in the Indian Ocean Dipole, as represented by the Dipole Mode Index (6.7% and 23.7% contribution, respectively). The abundance of red‐footed boobies, brown noddies, and white terns declined abruptly with greater distance to island (17.6%, 34.1%, and 41.1% contribution, respectively). We further quantified the effects of proximity to rat‐free and rat‐invaded islands on seabird distribution at sea and identified breaking point distribution thresholds. We detected areas of increased abundance at sea and habitat use‐age under a scenario where rats are eradicated from invaded nearby islands and recolonized by seabirds. Following rat eradication, abundance at sea of red‐footed booby, brown noddy, and white terns increased by 14%, 17%, and 3%, respectively, with no important increase detected for shearwaters. Our results have implication for seabird conservation and island restoration. Climate oscillations may cause shifts in seabird distribution, possibly through changes in regional productivity and prey distribution. Invasive species eradications and subsequent island recolonization can lead to greater access for seabirds to areas at sea, due to increased foraging or transiting through, potentially leading to distribution gains and increased competition. Our approach predicting distribution after successful eradications enables anticipatory threat mitigation in these areas, minimizing competition between colonies and thereby maximizing the risk of success and the conservation impact of eradication programs.
MicroRNA-23a acts as an oncogene in pancreatic carcinoma by targeting TFPI-2

Pancreatic carcinoma (PC) is a rapidly progressive, fatal malignant tumor with the poorest prognosis among all major carcinoma types. MicroRNAs (miRNAs/miRs) have been indicated to be key post-transcriptional regulatory factors, which are involved in cancer development. The present study was designed to investigate the effect of miR-23a on PC cell proliferation, metastasis and apoptosis. The expression of miR-23a was detected in a normal pancreatic ductal epithelial cell line and three PC cell lines, and miR-23a inhibitor or mimics were transfected into the Panc-1 and MiaPaCa2 PC cells. The association between miR-23a and tissue factor pathway inhibitor (TFPI)-2 was examined using a luciferase reporter assay. MTT and flow cytometry assays were used to assess cell viability and apoptosis, respectively. Furthermore, wound-healing, Transwell and Matrigel assays were used to evaluate cell migration and invasion abilities, and the protein expression level of TFPI-2 was determined using western blot analysis. The results of the present study revealed that miR-23a was upregulated in PC cells. Furthermore, TFPI-2 was identified as a downstream target of miR-23a, and TFPI-2 expression was found to be increased following miR-23a knockdown. In addition, functional assays revealed that downregulation of miR-23a decreased PC cell proliferation, migration and invasiveness and promoted cell apoptosis, while miR-23a overexpression exerted the opposite effects. Furthermore, TFPI-2 knockdown rescued the biological effects on PC cells, which were induced by miR-23a knockdown. The results of the present study indicated that miR-23a negatively modulated TFPI-2 expression in vitro and enhanced the malignant phenotypes of PC cells. Therefore, miR-23a may be a potential marker and/or target for the diagnosis and treatment of PC.
Activity Budget and Feeding Ecology of Geladas (Theropithecus gelada obscurus) around Abogedam Church West of Debre Berhan Town, Ethiopia

Geladas are the most distinctive of Ethiopian endemic mammals, representing the last extant species of primate genus that have a very restricted distribution in the northern Ethiopian plateau. The activity budget and feeding ecology of geladas (Theropithecus gelada obscurus) were studied around Abogedam Church, Ethiopia, from May to October 2014, encompassing dry and wet seasons. The scan sampling method was applied to collect behavioural data on the identified band. Activity scans were collected at 15-minute intervals for up to five minutes duration from 0700 to 1730 h. The activity recorded for each individual was the first activity that lasts for five seconds. During each scan, individuals were recorded as performing activities: feeding, moving, resting, playing, aggression, grooming, sexual activity, and others. On average, geladas devoted 57.19% feeding, 14.82% resting, 14.92% moving, 4.83% playing, 2.53% aggression, 4.14% grooming, 1.23% sexual activity, and 0.34% other activities such as vocalization, defecation, and urination. Forty-one plant species were consumed by geladas that belonged to 18 families of which 53.66% were grasses. This study provides basic information on further studies and motivates conservationists to plan the management of unprotected areas at the vicinity of agricultural lands where such endemic animals dwell.
Surgical Management of Cardiac Hydatid Cyst and the Residual Intramural Ectocyst

The cardiac hydatid cyst (HC) is a rare pathology and mostly is endemic in livestock raising countries. Patients do not have a specific presentation so it is mainly a diagnosis based on imaging. Finding HC anywhere in the body warrants looking for another hydatid in other organs. This is a case report of a young male who presented with nonspecific symptoms and during diagnostic workup, it happened that he has combined hepatic and cardiac HCs. The cardiac cyst was located intramurally in the interventricular septum and expanding down mostly to the left side of the diaphragmatic surface of the heart and partly crossing intramurally to the diaphragmatic surface of the right ventricle. Emergency open-heart surgery was performed; the endocyst was removed while intramural ectocyst was drained to prevent potential future residual space.
Effect of Ultrafine Powderization and Solid Dispersion Formation via Hot-Melt Extrusion on Antioxidant, Anti-Inflammatory, and the Human Kv1.3 Channel Inhibitory Activities of Angelica gigas Nakai

Angelica gigas Nakai (AGN) was first processed by ultrafine grinding technology and hot-melt extrusion (HME). The potential antioxidant and anti-inflammatory activities of AGN with a different process were compared, and the effect on the human Kv1.3 potassium channel was detected. The process of ultrafine powderization on AGN significantly increased the total phenolic and flavonoid contents, antioxidant activity, and DNA damage protective effect. On the contrary, AGN solid dispersion (AGN-SD) based on Soluplus® showed the highest inhibitory effect on NO production and the human Kv1.3 channel. In addition, AGN-SD inhibited the production of prostaglandin E2 and intracellular reactive oxygen species and the mRNA expression of inducible nitric oxide synthase, cyclooxygenase-2, interleukin 1β, and interleukin 6. Taken together, these results suggest that ultrafine powderization and solid dispersion formation via HME can significantly improve the biological activities of AGN. The results also suggested that ultrafine powderization and HME may be developed and applied in the pharmaceutical industry.
Obstructive Sleep Apnea and Cardiovascular Morbidities: A Review Article

In obstructive sleep apnea (OSA), there are brief episodes of partial or total upper airway obstruction during sleep, which leads to apnea or hypopneas. Much attention is required to understand OSA's effects on the human body, owing to how common but under-diagnosed this disorder remains. Though the role of OSA in cardiovascular (CV) disease is commonly discussed, it remains unclear how it induces changes in the human body. The intermittent and recurrent hypoxia occurring at the cellular level in this condition is critical for the dramatic changes observed. Vascular endothelial cell (VEC) injury and other mechanisms seen in OSA lead to changes in the CV system. OSA can take a toll on a person's overall functioning, especially with so much importance in today's time on preventing and treating cardiac-related deaths. A total of 31 published articles were included from the PubMed database for our literature review. Most of the studies showed a strong association of OSA with hypertension, especially resistant hypertension. Findings were consistent with OSA's independent role in causing CV diseases, included heart failure, coronary artery disease (cardiac ischemia), arrhythmias, and ischemic stroke. Continuous Positive Airway Pressure (CPAP) is one of the reliable and beneficial treatments for OSA patients. OSA is a treatable and modifiable risk factor for cardiac events and related deaths. The primary purpose of our review article was to address any existing gaps between OSA and its effect on the human body with particular emphasis on cardiovascular changes.
Nerve Root Sedimentation Sign: Can It Predict the Success for Surgical Intervention in Patients With Symptomatic Lumbar Spinal Stenosis?

Introduction: The use of interspinous process devices are less invasive surgical methods designed to manage mild to moderate lumbar spinal stenosis symptoms. Symptomatic relief may not be seen in all patients undergoing this procedure. Magnetic resonance imaging (MRI) parameters have been used to predict the success of clinical outcomes in patients with symptomatic lumbar spinal stenosis for decompressive surgeries. The purpose of this study was to determine the feasibility of using nerve root sedimentation sign to predict mid- to long-term clinical outcomes of patients treated with interspinous spacers for lumbar spinal stenosis. Methods: This was a retrospective study using prospective multicenter Food and Drug Administration Investigational Device Exemption (FDA IDE) trial (Superion™ and X-STOP®) data. Inclusion criteria were patients treated with interspinous spacers, aged 45 or older with lumbar spinal stenosis at one or more contiguous levels from L1 to L5 and symptoms of neurogenic claudication. Preoperative axial T2 weighted MRI images were used to determine nerve root sedimentation sign. Preoperative, six-week, one- and two-year postoperative clinical outcomes were measured using Oswestry Disability Index (ODI) scores. Clinical outcomes were compared between positive and negative nerve root sedimentation sign groups; p ≤0.05 was considered significant. Results: This study included n=374 patients; 40 excluded; 334 included (113=positive nerve root sedimentation sign (NRSS) (34%) and 221=negative NRSS (66%)). At six weeks, significant postoperative ODI correction was noted in both groups (p<0.001). No significant differences in ODI scores were identified between groups. A subgroup analysis with MRI image quality grade 3 and certainty determination grade 5, six-week postoperative ODI correction was significant in both groups. Six-week, one- and two-year postoperative ODI scores were greater by 6 points in the positive nerve root sedimentation sign group compared to the negative nerve root sedimentation sign group. Conclusions: Although satisfactory postoperative improvement occurred in both groups, there were statistically significant differences noted in certain sub-categories. The subgroup analysis indicated MRI image quality and nerve root sedimentation sign certainty of determination may be factors that may aid with planning the surgical management of lumbar spinal stenosis.
Transcriptomic, Proteomic, and Functional Long-Term Characterization of Multicellular Three-Dimensional Human Liver Microtissues

Abstract Three-Dimensional (3D) liver microtissues, specifically prepared from primary human hepatocytes (PHH) in coculture with nonparenchymal cells (NPCs), have been shown to be a valuable tool for in vitro toxicology. However, a lack of thorough characterization on a functional, transcriptomic, and proteomic level of such models during long-term cultivation is evident. By integrating multiple omics technologies, we provide in this study an in-depth long-term characterization of 3D microtissues composed of PHH from three different donors cocultured with primary NPCs. The 3D human liver microtissues (hLiMTs) exhibited stable adenosine triphosphate (ATP) content and albumin secretion over 5 weeks. Histological analysis indicated a healthy liver tissue with polarized expression of bile salt export pump (BSEP) and multidrug resistance protein 2 (MRP2) in a structure reminiscent of bile canaliculi. The 3D microtissues exhibited stable basal and inducible cytochrome P450 activities up to 5 weeks in culture. Analysis of 40,716 transcripts using RNA arrays revealed distinct similarities to native human liver gene expression. Long-term culture showed a stable phenotype up to 5 weeks, with differences in liver gene expression primarily attributed to individual donors. Proteomic profiling of 2200 unique proteins by label-free LC-MS/MS revealed a relatively stable protein expression where only 7.3% were up- or downregulated more than twofold from day 7 to 35 in culture. Taken together, these results suggest that hLiMTs represent a responsive and physiologically relevant in vitro liver model that maintains stable function over 5 weeks and is therefore well suited for repeated-dose toxicity testing.