Miracle-dz/UniFAR-FTUs huggingface dataset:
Transport of Ca2+ and Ca2+-Dependent Permeability Transition in the Liver and Heart Mitochondria of Rats with Different Tolerance to Acute Hypoxia

The work examines the kinetic parameters of Ca2+ uptake via the mitochondrial calcium uniporter complex (MCUC) and the opening of the Ca2+-dependent permeability transition pore (MPT pore) in the liver and heart mitochondria of rats with high resistance (HR) and low resistance (LR) to acute hypoxia. We found that the rate of Ca2+ uptake by mitochondria of the liver and heart in HR rats is higher than that in LR rats, which is associated with a higher level of the channel-forming subunit MCU in liver mitochondria of HR rats and a lower content of the dominant-negative channel subunit MCUb in heart mitochondria of HR rats. It was shown that the liver mitochondria of HR rats are more resistant to the induction of the MPT pore than those of LR rats (the calcium retention capacity of liver mitochondria of HR rats was found to be 1.3 times greater than that of LR rats). These data correlate with the fact that the level of F0F1-ATP synthase, a possible structural element of the MPT pore, in the liver mitochondria of HR rats is lower than in LR rats. In heart mitochondria of rats of the two phenotypes, no statistically significant difference in the formation of the MPT pore was revealed. The paper discusses how changes in the expression of the MCUC subunits and the putative components of the MPT pore can affect Ca2+ homeostasis of mitochondria in animals with originally different tolerance to hypoxia and in hypoxia-induced tissue injury.
A Bbiomechanical Assessment of Active Video Gaming in Children with Cerebral Palsy Detailing Energy Expenditure, Muscle Activations, and Upper Limb Kinematics

This thesis evaluated energy levels, muscle activity, and upper limb kinematics during AVG play in children with cerebral palsy (CP). For context, a systematic review was conducted, which found that AVGs elicited light to moderate physical activity in typically developing children. In children with CP, moderate levels of physical activity were achieved for Dance Dance Revolution and Wii Boxing, while light levels of physical activity were achieved for Wii Bowling and Wii Tennis. Muscle activity was highest during Wii Boxing, but remained below the maximum voluntary effort for all games and muscles. Angular velocities and accelerations were significantly larger in the dominant limb compared to the hemiplegic limb. When children played against a real opponent, dominant arm activity increased, while hemiplegic arm activity decreased. The results of this thesis indicate that AVGs may be an enjoyable and relatively safe option for children with CP to attain moderate physical activity.
Vrednotenje družbene trajnostnosti malega industrijskega mesta: primer Velenja

Namen prispevka je poskus vrednotenja družbenega vidika trajnostnega razvoja Velenja, ki v evropskem merilu sodi med mala industrijska mesta. Pri vrednotenju smo uporabili v tujini uveljavljeno orodje Social Sustainability Framework in ga prilagodili lokalnemu kontekstu. Ugotovili smo, da je Velenje mesto z visoko stopnjo družbene trajnostnosti v treh od stirih ocenjenih sklopov: dobrin in družbene infrastrukture, družbenega in kulturnega življenja ter vpliva, ki ga ima lokalno prebivalstvo na razvoj. Najvecja slabost mesta je slabsa prilagodljivost in prožnost kot posledica na dveh vecjih podjetjih temeljecega gospodarstva. Ocenjujemo, da ima uporabljeno orodje veliko uporabno vrednost za urbano nacrtovanje in urbani razvoj. // The purpose of the article was to evaluate the social sustainability of Velenje, which falls into the category of small industrial towns on the European scale. The evaluation was done by using Social Sustainability Framework, an established tool that was adjusted to the local context. It was determined that Velenje is a town with a high level of social sustainability both in the areas of goods and social infrastructure, social and cultural life, as well as the influence that the local inhabitants have on development. The town’s greatest disadvantage is its reduced adaptability level and flexibility, which is the consequence of an economy based on only two major companies. We believe that the tool has the potential to be useful for urban planning and development.
Prediction of Blasting Cost in Limestone Mines Using Gene Expression Programming Model and Artificial Neural Networks

The use of blasting cost (BC) prediction to achieve optimal fragmentation is necessary in order to control the adverse consequences of blasting such as fly rock, ground vibration, and air blast in open-pit mines. In this research work, BC is predicted through collecting 146 blasting data from six limestone mines in Iran using the artificial neural networks (ANNs), gene expression programming (GEP), linear multivariate regression (LMR), and non-linear multivariate regression (NLMR) models. In all models, the ANFO value, number of detonators, Emolite value, hole number, hole length, hole diameter, burden, spacing, stemming, sub-drilling, specific gravity of rock, hardness, and uniaxial compressive strength are used as the input parameters. The ANN model results in the test stage indicating a higher correlation coefficient (0.954) and a lower root mean square error (973) compared to the other models. In addition, it has a better conformity with the real blasting costs in comparison with the other models. Although the ANNs method is regarded as one of the intelligent and powerful techniques in parameter prediction, its most important fault is its inability to provide mathematical equations for engineering operations. In contrast, the GEP model exhibits a reliable output by presenting a mathematical equation for BC prediction with a correlation coefficient of 0.933 and a root mean square error of 1088. Based on the sensitivity analysis, the spacing and ANFO values have the maximum and minimum effects on the BC function, respectively. The number of detonators, Emolite value, hole number, specific gravity, hardness, and rock uniaxial compressive strength have a positive correlation with BC, while the ANFO value, hole length, hole diameter, burden, spacing, stemming, and sub-drilling have a negative correlation with BC.
Self-neglect 1: Recognising Features And Risk Factors

Day, M.R. , Leahy-Warren, P. (2008) Self-neglect 1: recognising features and risk factors. Nursing Times; 104: 24, 26-27. This is the first of a two-part unit on self-neglect. Part 1 defines and describes the characteristics of self-neglect and identifies those at greatest risk. It also distinguishes between intentional and non-intentional self-neglect.
A new patch antenna for ultra wide band communication applications

A printed monopole patch Ultra Wide Band (UWB) antenna for use in UWB application is proposed in this paper. The proposed antenna consists of a patch with appropriate dimensions on one side of a dielectric substrate, and a partial ground plane on the other side of the substrate. The techniques that used to enhance the bandwidth are the partial ground plane, feed point position and adjusted feed gap. The substrate that is used in the proposed antenna is Fr4 epoxy, the optimum dimensions of the antenna are 40mm×28mm×1.5mm this antenna designed by HFSS program. The band achieved by the proposed antenna is from 3.6GHz to 15GHz. This antenna is fabricated in the ministry of science and technology Baghdad-Iraq and a good agreement between simulation and measured S11 is achieved.
An Unusual Etiology Of Vascular Toxicity And Its Treatment With Cervical Sympathetic Blockage

Gemcitabine is a nucleoside analogue used commonly in chemotherapy for solid tumors. One of its common side effects is vascular toxicity. Case due to Gemcitabine therapy is a urethral carcinoma. The patient was admitted with muscle pain in upper extremity of his finger with movement, sensitiveness, hypoesthesia, pallor, and cyanosis during the second cure of Gemcitabine treatment. After he was diagnosed with microangiopathy due to Gemcitabine, vasodilatation therapy and ten sets of cures of cervical sympathetic blockage were applied. Following the treatment, sign and symptoms disappeared dramatically. With regard to this case we believe that cervical sympathetic blockade is valuable as surgical sympathectomy in early stages of convenient cases.
Geminin is required for Hox gene regulation to pattern the developing limb

Development of the complex structure of the vertebrate limb requires carefully orchestrated interactions between multiple regulatory pathways and proteins. Among these, precise regulation of 5’ Hox transcription factor expression is essential for proper limb bud patterning and elaboration of distinct limb skeletal elements. Here, we identified Geminin (Gmnn) as a novel regulator of this process. A conditional model of Gmnn deficiency resulted in loss or severe reduction of forelimb skeletal elements, while both the forelimb autopod and hindlimb were unaffected. 5’ Hox gene expression expanded into more proximal and anterior regions of the embryonic forelimb buds in this Gmnn-deficient model. A second conditional model of Gmnn deficiency instead caused a similar but less severe reduction of hindlimb skeletal elements and hindlimb polydactyly, while not affecting the forelimb. An ectopic posterior SHH signaling center was evident in the anterior hindlimb bud of Gmnn-deficient embryos in this model. This center ectopically expressed Hoxd13, the HOXD13 target Shh, and the SHH target Ptch1, while these mutant hindlimb buds also had reduced levels of the cleaved, repressor form of GLI3, a SHH pathway antagonist. Together, this work delineates a new role for Gmnn in modulating Hox expression to pattern the vertebrate limb. Summary This work identifies a new role for Geminin in mouse limb development. Geminin is a nuclear protein that regulates gene expression to control several other aspects of vertebrate development.
The spatial competition from the perspective of competitive strategy

Even though the spatial competition is a crucial aspect of the competitive strategy of firms, it is still little approached in the competitive and marketing strategy literature. As such, the association between formal spatial models and thee practice of spatial competition between firms should be approached. Addressing this gap in this article, we propose a more formal view of the spatial competition. Based on the concepts of the value of displacement for the customer and the value of location we present several aspects related to the difference in the location of outlets in a hypothetical city. Several measures such as market share, competitive advantage, and value of location, are calculated in this model. This article opens a new perspective to study the competitive positioning of firms in spatial markets.
Resonator Based Chipless RFID: A Frequency Domain Comprehensive Review

The fundamental concept and salient details about passive resonators in chipless radio frequency identification (RFID) technology are presented in this review article. The analysis also intends to assist the advancement of chipless autoidentification technology by addressing constraints, such as price, physical footprint, and coding capacity. The study makes it clear that resonators are the fundamental building blocks of modern chipless RFID industries. They are capable enough to enhance the detection performance, encoding ability, and information storage capacity that increase the usage of the transponder in a multitude of applications in various retailing and medical domains. Importance is given to smart materials and metamaterials that utilize resonators from an industrial standpoint. This article examines current developments in RFID resonators and the problems that they inevitably bring with them, such as sensitivity, selectivity, interference, collision, polarization, and read range.
Anaesthetic management of a case of giant cerebral aneurysm with persistent hypoglossal artery

Abstract The persistent hypoglossal artery is a rare carotid basilar anastomosis associated with hypoplastic or absent vertebral arteries. We report a case of clipping of a 2.5 cm size giant aneurysm just distal to the persistent hypoglossal branch, using intra-arterial balloon occlusion and adenosine induced near flow arrest method. It was an anaesthetic challenge to maintain haemodynamic and homeostatic equilibrium throughout the procedure.
Macronutrient malabsorption in acute diarrhea: Prevalence and affecting factors

Introduction Diarrhea remains a major problem for community health in Indonesia. More than 25% of children with severe diar- rhea suffer from malabsorption syndrome. Objectives This study aimed to determine the age range of chil- dren with acute diarrhea, the prevalence of macronutrient malab- sorption, and the relationship between age and bacterial infec- tion in macronutrient malabsorption. Methods This was a cross-sectional study, subjects were chil- dren aged 0-59 months with acute diarrhea whose stools were obtained and examined in the laboratory of Gastrohepatology Division, Department of Child Health, Cipto Mangunkusumo Hospi- tal, Jakarta from January 2002 to December 2003. Results Children with acute diarrhea were mostly in the age range of 0-11 months (61%). The prevalence of lactose malab- sorption was 11%, carbohydrate malabsorption was 19%, and fat malabsorption was 51%. Moreover, the age group of 0-11 months had a 1.5 times greater possibility of lactose and fat malabsorption compared to that of 12-59 months. The 12-59 months age group had a greater possibility of suffering carbohydrate maldigestion (70%). The group of children who did not suffer from bacterial infection had a higher prevalence of lactose mal- absorption (54%), carbohydrate maldigestion (65%), and fat malabsorption (58%). Conclusions Acute diarrhea occurred more frequently in the age of 0-11 months. There was a significant correlation between the age groups of 0-11 months and 12-59 months in experiencing macronutrient malabsorption. Lactose malabsorption, carbohy- drate maldigestion, and fat malabsorption were encountered more frequently in the group that did not have bacterial infection
Teat and Udder Disease Detection on Cattle using Machine Learning

In high milk yielding cattle udder and teat diseases are common. Due to this the farmers are facing more problem in production and quality of milk. In agriculture, research of automatic cow disease is essential in monitoring large population of cows, and If symptoms appear on the udder or teat, the disease should be automatically detected immediately. There is a need for automatic system where the Cow Teat and Udder diseases are detected, the effect of disease on milk yield and what medicines should be used for its cure. The aim of this work is to solve the problem of detecting and preventing diseases of different breed of cows. To determine the optimal architecture for deep learning, several models are considered. As a source of the training data, the cow teat and udder images of cow in villages are used. For this approach automatic classifier Convolutional Neural Networks (CNN) model will be used for training the model based on learning with some training samples. The developed model is then considered for classification using Support Vector Machine (SVM) deployed as a web Application which can detect 3 types of diseases among cows viz. Mastitis, Udder score and Frozen teats also classifying healthy cows among the datasets. Validation Accuracy Results show that the system can show the accuracy 93.50 % and Training Accuracy is approximately 97.87%
The College Student’s Religious Tattoo: Respect, Reverence, Remembrance

ABSTRACT Tattoos are now a generally socially accepted means of expressing one’s thoughts, beliefs, and affiliations. Using two types of data – interviews (N = 11) and survey responses to an open-ended prompt (N = 85) – this article focuses on the meanings, motivations, and rationales that young college student adults have for their self-identified religious tattoos. We found that their responses generally fell into three categories: respect, reverence, and remembrance. Additionally, we divided the respondents’ self-described motivations and descriptions into two subcategories that described the uses those tattoos had for respondents. We discovered that even tattoos that do not appear to be religious to an observer may actually have varying religious meanings and uses for respondents – even for respondents who describe themselves as a-religious or atheists. We also find that the more public the body placement, the more likely the respondent wishes to use the tattoo for evangelical and group affiliation purposes.
Risk factors for diarrhoea and respiratory illness and the impact of water and hygiene interventions

Upscaling cost-effective water, sanitation and hygiene interventions such as treating water at point-of-use or improving hygiene behaviour remains difficult despite their proven health benefits. Findings from this thesis could potentially help future researchers to improve selection and implementation of water treatment and hygiene interventions at the community level. Further research is necessary to understand the reasons for poor uptake of the pre-tested effective interventions and how behaviour change interventions with high quality could be delivered at a larger scale. Affordable community-level interventions that reliably separate faeces from the environment, food and water remain important areas for future research.
Molecular analysis of T cell receptors : mapping T cell recognition and repertoire in two human immune responses.

The aim of this thesis was to characterise the T cell receptors (TCR) involved in two hum an immune responses, and their interaction w ith antigen in the context of major histocompatibility molecules. The TCR of a panel of hum an CD4+ house dust mite specific T cell clones were analysed in the context of the peripheral TCR repertoire. The clones were found to use a restricted set of TCR variable (V) genes, although there was little conservation of junctional sequences. Several clones had identical TCR at the sequence level, despite the fact that they had been isolated in different years. Screening of amplified TCR transcripts from several years later suggested the presence in vivo of long lived dominant T cell clones in this response. The hum an T cell response to the influenza haemagglutinin peptide HA 307 319 in the context of the class 11 molecule DRl was studied in two hum an T cell clones derived from different individuals. One of these clones, HA1.7, responds equally to HA 307 319/DR4, while the other, Cl-1, does not. Sequencing of amplified TCR transcripts revealed that the two clones express highly related TCRa chains, w ith a conserved junctional motif, bu t very different TCRp chains. Modelling studies led to the prediction that a conserved glutamic acid residue (94E) in the TCRa junctional region might be critical to peptide recognition. After initial investigation of models for expression of TCR, mutagenesis studies of the HA1.7 TCRa chain were performed using transfection into the hum an T cell line JRT3T3.5, and the rat basophil line (RBL). In the RBL line, ligation of the transfected TCR leads to degranulation, measurable as serotonin release. TCRa mutants carrying either alanine or lysine at position 94 no longer recognised the HA 307 319 /D R l complex. These mutants were not rescued by peptides carrying reciprocal charge changes.
Remote sensing-based river discharge estimation for a small river flowing over the high mountain regions of the Tibetan Plateau

ABSTRACT River discharge, as one of the most essential climate variables, plays a vital role in the water cycle. Small-scale headwater catchments including high-mountain regions of Tibetan Plateau (TP) Rivers are mostly ungauged. Satellite technology shows its potential to fill this gap with a high correlation of satellite-derived effective river width and corresponding in-situ gauged discharge. This study is innovative in estimating daily river discharge using modified Manning equation (Model 1), Bjerklie equation (Model 2), and Rating curve approach (Model 3) by combining river surface hydraulic variables directly derived from remote-sensing datasets with other variables indirectly derived from empirical equations, which greatly contributes to the improvement of river flow measurement information especially over small rivers of TP. We extracted the effective width from Landsat image and flow depth via hydraulic geometry approach. All the input parameters directly or indirectly derived from remote sensing were combined and substituted into the fundamental flow equations/models to estimate discharges of Lhasa River. The validation of all three models’ results against the in-situ discharge measurements shows a strong correlation (the Nash–Sutcliffe efficiency coefficient (NSE) and the coefficient of determination (R 2) values ≥0.993), indicating the potentiality of the models in accurately estimating daily river discharges. Trends of an overestimation of discharge by Model 1 and underestimation by Model 2 are observed. The discharge estimation by using Model 3 outperforms Model 1 and Model 2 due to the uncertainties associated with the estimation of input parameters in the other two models. Generally, our discharge estimation methodology performs well and shows a superior result as compared with previously developed multivariate empirical equations and its application for other places globally can be the focus of upcoming studies.
Estrus Synchronization Using Prostaglandin F2α (PGF2α) and Combination of PGF2α and Gonadotropin-Releasing Hormone In Ongole Crossbred

The response of estrus can be enhanced by providing PGF2α and a combination of PGF2αGnRH so that the time of mating using Artificial Insemination (AI) can be held precisely. This study aims to compare the response of estrus synchronization using PGF2α compare to PGF2α-GnRH. Twenty female cattle Ongole Crossbreds, 4-6 years, BCS average of 3-4 were used in this research. Cattle were selected based on their luteal phase at the days of 7 to 18 by rectal examination. Then, all of the cattle were injected by cloprostenol® with a dose of 500 ug intrauterine. Ten of the animals were injected by 2.5 mL of Fertagyl® intramuscularly after 48 hours then continued observing and response estrus detection. The onset of estrus using PGF2α was detected on 75.94 ± 0.78, while 41.57 ± 28.40 hours for PGF2α-GnRH Using statistical, there was a significant difference (P<0.05). Duration of estrus phase using PGF2α was 24.65 ± 0.49 whereas PGF2α-GnRH was 10.88 ± 7.45 hours. Using statistical methods, there was a significant difference (P <0.05). It could be concluded that the use of PGF2α was more effective for the duration and intensity of estrus, and a combination of PGF2α -GnRH is more effective for stimulating estrus.