Miracle-dz/UniFAR-FTUs huggingface dataset:
Implant protected occlusion: A comprehensive review

Complexities in the study of occlusion have set tough challenges for both under graduate and post-graduate students and the introduction of osseointegrated implants has further complicated these challenges. The principles of occlusion are applied by dentists for the natural dentition directly to implant-supported and retained restorations. Although successful, this rationale at times may result in overly complex or simplified treatment protocols and outcomes. The focus of this review is mainly on currently available scientific literature involving dental implant occlusion. The authors reviewed the English peer-reviewed literature prior to 1996 in a comprehensive manner, and the material post 1996 was reviewed electronically using MEDLINE. Electronic searches of the literature were performed in MEDLINE using key words - cohort studies, complete denture occlusion, clinical trial, case studies, dental implant function, dental implant occlusion, dental implant occlusion research, dental implant functional loading, dental implants, dental occlusion, dental occlusion research, denture function, denture occlusion, dentures, implant function, implant functional loading, implant occlusion, occlusion, and removable partial denture occlusion - in various combinations to obtain potential references for review. A total of 4445 English language titles were obtained, many of which were duplicates due to multiple searches. Manual hand searching of the MEDLINE reference list was performed to identify any articles missed in the original search.
Damage to the Insula Disrupts Addiction to Cigarette Smoking

A number of brain systems have been implicated in addictive behavior, but none have yet been shown to be necessary for maintaining the addiction to cigarette smoking. We found that smokers with brain damage involving the insula, a region implicated in conscious urges, were more likely than smokers with brain damage not involving the insula to undergo a disruption of smoking addiction, characterized by the ability to quit smoking easily, immediately, without relapse, and without persistence of the urge to smoke. This result suggests that the insula is a critical neural substrate in the addiction to smoking.
Animal Models of Orthopoxvirus Infection

Smallpox was one of the most devastating diseases known to humanity. Although smallpox was eradicated through a historically successful vaccination campaign, there is concern in the global community that either Variola virus (VARV), the causative agent of smallpox, or another species of Orthopoxvirus could be used as agents of bioterrorism. Therefore, development of countermeasures to Orthopoxvirus infection is a crucial focus in biodefense research, and these efforts rely on the use of various animal models. Smallpox typically presented as a generalized pustular rash with 30 to 40% mortality, and although smallpox-like syndromes can be induced in cynomolgus macaques with VARV, research with this virus is highly restricted; therefore, animal models with other orthopoxviruses have been investigated. Monkeypox virus causes a generalized vesiculopustular rash in rhesus and cynomolgus macaques and induces fatal systemic disease in several rodent species. Ectromelia virus has been extensively studied in mice as a model of orthopoxviral infection in its natural host. Intranasal inoculation of mice with some strains of vaccinia virus produces fatal bronchopneumonia, as does aerosol or intranasal inoculation of mice with cowpox virus. Rabbitpox virus causes pneumonia and fatal systemic infections in rabbits and can be naturally transmitted between rabbits by an aerosol route similar to that of VARV in humans. No single animal model recapitulates all known aspects of human Orthopoxvirus infections, and each model has its advantages and disadvantages. This article provides a brief review of the Orthopoxvirus diseases of humans and the key pathologic features of animal models of Orthopoxvirus infections.
Mussel-Inspired Surface Chemistry for Multifunctional Coatings

We report a method to form multifunctional polymer coatings through simple dip-coating of objects in an aqueous solution of dopamine. Inspired by the composition of adhesive proteins in mussels, we used dopamine self-polymerization to form thin, surface-adherent polydopamine films onto a wide range of inorganic and organic materials, including noble metals, oxides, polymers, semiconductors, and ceramics. Secondary reactions can be used to create a variety of ad-layers, including self-assembled monolayers through deposition of long-chain molecular building blocks, metal films by electroless metallization, and bioinert and bioactive surfaces via grafting of macromolecules.
A multicast interface for UNIX 4.3

The UNIX 4.3 operating system, like its predecessor UNIX 4.2, is designed to allow interprocess communications between pairs of processes using sockets — pairs of integers identifying specific hosts and ports — which are associated with a process. In this paper a software package which allows interprocess communications between many UNIX processes (as opposed to two) is presented.
Reciprocal Binding of PARP-1 and Histone H1 at Promoters Specifies Transcriptional Outcomes

Nucleosome-binding proteins act to modulate the promoter chromatin architecture and transcription of target genes. We used genomic and gene-specific approaches to show that two such factors, histone H1 and poly(ADP-ribose) polymerase-1 (PARP-1), exhibit a reciprocal pattern of chromatin binding at many RNA polymerase II–transcribed promoters. PARP-1 was enriched and H1 was depleted at these promoters. This pattern of binding was associated with actively transcribed genes. Furthermore, we showed that PARP-1 acts to exclude H1 from a subset of PARP-1–stimulated promoters, suggesting a functional interplay between PARP-1 and H1 at the level of nucleosome binding. Thus, although H1 and PARP-1 have similar nucleosome-binding properties and effects on chromatin structure in vitro, they have distinct roles in determining gene expression outcomes in vivo.
Molecular Carcinogenesis of Canine Mammary Tumors

Studies focusing on the molecular basis of canine mammary tumors (CMT) have long been hampered by limited numbers of molecular tools specific to the canine species. The lack of molecular information for CMT has impeded the identification of clinically relevant tumor markers beyond histopathology and the introduction of new therapeutic concepts. Additionally, the potential use for the dog as a model for human breast cancer is debatable until questions are answered regarding cellular origin, mechanisms, and cellular pathways. During the past years, increasing numbers of canine molecular tools have been developed on the genomic, RNA, and protein levels, and an increasing number of studies have shed light on specific aspects of canine carcinogenesis, particularly of the mammary gland. This review summarizes current knowledge on the molecular carcinogenesis of CMT, including the role of specific oncogenes, tumor suppressors, regulators of apoptosis and DNA repair, proliferation indices, adhesion molecules, circulating tumor cells, and mediators of angiogenesis in CMT progression and clinical behavior. Whereas the data available are far from complete, knowledge of molecular pathways has a significant potential to complement and refine the current diagnostic and therapeutic approach to this tumor type. Furthermore, current data show that significant similarities and differences exist between canine and human mammary tumors at the molecular level. Clearly, this is only the beginning of an understanding of the molecular mechanisms of CMT and their application in clinical patient management.
A user interface specification for a program debugging and measuring environment

A high level of complexity is involved in program dynamics. A number of tools have been developed to assist the programmer in mastering this complexity in the various phases of software development. However, these tools are specifically oriented towards the monitoring of particular aspects of program behaviour. This paper presents the results of a systematic attempt at defining the user interface to an environment for program debugging, program performance evaluation and program structure analysis. This environment can be used to implement many common debugging techniques, and to evaluate important program performance indexes and program structure statistics. It supports both sequential and concurrent block‐oriented high‐level languages.
Arabidopsis CLV3 Peptide Directly Binds CLV1 Ectodomain

CLV1, which encodes a leucine-rich repeat receptor kinase, and CLV3, which encodes a secreted peptide, function in the same genetic pathway to maintain stem cell populations in Arabidopsis shoot apical meristem. Here, we show biochemical evidence, by ligand binding assay and photoaffinity labeling, that the CLV3 peptide directly binds the CLV1 ectodomain with a dissociation constant of 17.5 nM. The CLV1 ectodomain also interacts with the structurally related CLE peptides, with distinct affinities depending on the specific amino acid sequence. Our results provide direct evidence that CLV3 and CLV1 function as a ligand-receptor pair involved in stem cell maintenance.
Imaging Nucleophilic Substitution Dynamics

Anion-molecule nucleophilic substitution (SN2) reactions are known for their rich reaction dynamics, caused by a complex potential energy surface with a submerged barrier and by weak coupling of the relevant rotational-vibrational quantum states. The dynamics of the SN2 reaction of Cl– + CH3I were uncovered in detail by using crossed molecular beam imaging. As a function of the collision energy, the transition from a complex-mediated reaction mechanism to direct backward scattering of the I– product was observed experimentally. Chemical dynamics calculations were performed that explain the observed energy transfer and reveal an indirect roundabout reaction mechanism involving CH3 rotation.
Designed Protein-Protein Association

The analysis of natural contact interfaces between protein subunits and between proteins has disclosed some general rules governing their association. We have applied these rules to produce a number of novel assemblies, demonstrating that a given protein can be engineered to form contacts at various points of its surface. Symmetry plays an important role because it defines the multiplicity of a designed contact and therefore the number of required mutations. Some of the proteins needed only a single side-chain alteration in order to associate to a higher-order complex. The mobility of the buried side chains has to be taken into account. Four assemblies have been structurally elucidated. Comparisons between the designed contacts and the results will provide useful guidelines for the development of future architectures.
μC++: Concurrency in the object‐oriented language C++

We present a design, including its motivation, for introducing concurrency into C++. The design work is based on a set of requirements and elementary execution properties that generate a corresponding set of programming language constructs needed to express concurrency. The new constructs continue to support object‐oriented facilities such as inheritance and code reuse. Features that allow flexibility in accepting and subsequently postponing servicing of requests are provided. Currently, a major portion of the design is implemented, supporting concurrent programs on shared‐memory uniprocessor and mulitprocessor computers.
Comparing and contrasting unstructured interviews with newly qualified nurses and senior health service personnel

Fourteen newly qualified nurses and 27 senior health service personnel were interviewed, using an unstructured format, for a study exploring careers guidance. Through comparing and contrasting the two sets of interviews, important differences in the approaches required to elicit trustworthy data emerged. This paper covers strategies used to encourage participation, establish rapport, manage the interview, and keep the interview productive with members of the two groups. The implications of sampling strategies, the interview setting and gender issues are also considered.
Cutaneous Lymphomas in European Pet Rabbits (Oryctolagus cuniculus)

Cutaneous lymphoma is a common skin neoplasm of pet rabbits in Europe but is rarely reported in pet rabbits in North America. These neoplasms have not been previously characterized, nor has the cause for the apparent predilection for cutaneous lymphoma in European pet rabbits compared with North American pet rabbits been investigated. In this retrospective study, the authors morphologically and immunohistochemically characterized 25 cutaneous lymphomas in European pet rabbits according to the World Health Organization classification. Tumors were classified as diffuse large B cell lymphomas, with 14 lymphomas exhibiting a centroblastic/centrocytic subtype and 11 tumors exhibiting a T cell–rich B cell subtype. To investigate a potential viral etiology of these lymphomas, 3 diffuse large B cell and 3 T cell–rich B cell lymphomas were evaluated by polymerase chain reaction for retroviral and herpesviral genes. Neither virus was detected. In contrast to other domestic animals, cutaneous lymphomas in European pet rabbits were highly pleomorphic and frequently contained multinucleated giant cells. Unexpectedly, the second most common subtype was T cell–rich B cell lymphoma, a subtype that is rare in species other than horses. Based on a limited number of samples, there was no support for a viral etiology that would explain the higher incidence of lymphoma in European pet rabbits compared with American pet rabbits. Further investigation into genetic and extrinsic factors associated with the development of these tumors is warranted.
The Size, Scale, and Shape of Cities

Despite a century of effort, our understanding of how cities evolve is still woefully inadequate. Recent research, however, suggests that cities are complex systems that mainly grow from the bottom up, their size and shape following well-defined scaling laws that result from intense competition for space. An integrated theory of how cities evolve, linking urban economics and transportation behavior to developments in network science, allometric growth, and fractal geometry, is being slowly developed. This science provides new insights into the resource limits facing cities in terms of the meaning of density, compactness, and sprawl, and related questions of sustainability. It has the potential to enrich current approaches to city planning and replace traditional top-down strategies with realistic city plans that benefit all city dwellers.
Titan's Rotation Reveals an Internal Ocean and Changing Zonal Winds

Cassini radar observations of Saturn's moon Titan over several years show that its rotational period is changing and is different from its orbital period. The present-day rotation period difference from synchronous spin leads to a shift of ∼0.36° per year in apparent longitude and is consistent with seasonal exchange of angular momentum between the surface and Titan's dense superrotating atmosphere, but only if Titan's crust is decoupled from the core by an internal water ocean like that on Europa.
Gene Regulation by Transcription Factors and MicroRNAs

The properties of a cell are determined by the genetic information encoded in its genome. Understanding how such information is differentially and dynamically retrieved to define distinct cell types and cellular states is a major challenge facing molecular biology. Gene regulatory factors that control the expression of genomic information come in a variety of flavors, with transcription factors and microRNAs representing the most numerous gene regulatory factors in multicellular genomes. Here, I review common principles of transcription factor– and microRNA-mediated gene regulatory events and discuss conceptual differences in how these factors control gene expression.
Observation of Giant Diffusivity Along Dislocation Cores

Diffusion of atoms in a crystalline lattice is a thermally activated process that can be strongly accelerated by defects such as grain boundaries or dislocations. When carried by dislocations, this elemental mechanism is known as “pipe diffusion. ” Pipe diffusion has been used to explain abnormal diffusion, Cottrell atmospheres, and dislocation-precipitate interactions during creep, although this rests more on conjecture than on direct demonstration. The motion of dislocations between silicon nanoprecipitates in an aluminum thin film was recently observed and controlled via in situ transmission electron microscopy. We observed the pipe diffusion phenomenon and measured the diffusivity along a single dislocation line. It is found that dislocations accelerate the diffusion of impurities by almost three orders of magnitude as compared with bulk diffusion.
Reducing memory requirements in reachability‐based finite automata operations

New applications of finite automata, such as computational linguistics and asynchronous circuit simulation, can require automata of millions or even billions of states. All known construction methods (in particular, the most effective reachability‐based ones that save memory, such as the subset construction, and simultaneously minimizing constructions, such as Brzozowski's) have intermediate memory usage much larger than the final automaton, thereby restricting the maximum size of the automata which can be built. In this paper, I present a reachability‐based optimization which can be used in most of these construction algorithms to reduce the intermediate memory requirements. The optimization is presented in conjunction with an easily understood (and implemented) canonical automaton construction algorithm. Copyright © 2003 John Wiley & Sons, Ltd.
Local Positive Feedback Regulation Determines Cell Shape in Root Hair Cells

The specification and maintenance of growth sites are tightly regulated during cell morphogenesis in all organisms. ROOT HAIR DEFECTIVE 2 reduced nicotinamide adenine dinucleotide phosphate (RHD2 NADPH) oxidase–derived reactive oxygen species (ROS) stimulate a Ca2+ influx into the cytoplasm that is required for root hair growth in Arabidopsis thaliana. We found that Ca2+, in turn, activated the RHD2 NADPH oxidase to produce ROS at the growing point in the root hair. Together, these components could establish a means of positive feedback regulation that maintains an active growth site in expanding root hair cells. Because the location and stability of growth sites predict the ultimate form of a plant cell, our findings demonstrate how a positive feedback mechanism involving RHD2, ROS, and Ca2+ can determine cell shape.
Wildlife Reservoirs of Bovine Tuberculosis Worldwide: Hosts, Pathology, Surveillance, and Control

Bovine tuberculosis due to Mycobacterium bovis is a zoonotic disease classically carried by cattle and spilling over into humans primarily by the ingestion of milk. However, in recent decades, there have been many endemic geographic localities where M. bovis has been detected infecting wildlife reservoirs, limiting the progress toward eradication of this disease from cattle. These include cervids in North America, badgers in Great Britain, feral pigs in Europe, brushtailed possums in New Zealand, and buffalo in South Africa. An overview of these wildlife hosts will provide insight into how these reservoirs maintain and spread the disease. In addition, the authors summarize the pathology, current ongoing methods for surveillance, and control. In many instances, it has proven to be more difficult to control or eradicate bovine tuberculosis in wild free-ranging species than in domesticated cattle. Furthermore, human influences have often contributed to the introduction and/or maintenance of the disease in wildlife species. Finally, some emerging themes regarding bovine tuberculosis establishment in wildlife hosts, as well as conclusions regarding management practices to assist in bovine tuberculosis control and eradication in wildlife, are offered.
Pathology of Experimental Aerosol Zaire Ebolavirus Infection in Rhesus Macaques

There is limited knowledge of the pathogenesis of human ebolavirus infections and no reported human cases acquired by the aerosol route. There is a threat of ebolavirus as an aerosolized biological weapon, and this study evaluated the pathogenesis of aerosol infection in 18 rhesus macaques. Important and unique findings include early infection of the respiratory lymphoid tissues, early fibrin deposition in the splenic white pulp, and perivasculitis and vasculitis in superficial dermal blood vessels of haired skin with rash. Initial infection occurred in the respiratory lymphoid tissues, fibroblastic reticular cells, dendritic cells, alveolar macrophages, and blood monocytes. Virus spread to regional lymph nodes, where significant viral replication occurred. Virus secondarily infected many additional blood monocytes and spread from the respiratory tissues to multiple organs, including the liver and spleen. Viremia, increased temperature, lymphocytopenia, neutrophilia, thrombocytopenia, and increased alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transpeptidase, total bilirubin, serum urea nitrogen, creatinine, and hypoalbuminemia were measurable mid to late infection. Infection progressed rapidly with whole-body destruction of lymphoid tissues, hepatic necrosis, vasculitis, hemorrhage, and extravascular fibrin accumulation. Hypothermia and thrombocytopenia were noted in late stages with the development of disseminated intravascular coagulation and shock. This study provides unprecedented insight into pathogenesis of human aerosol Zaire ebolavirus infection and suggests development of a medical countermeasure to aerosol infection will be a great challenge due to massive early infection of respiratory lymphoid tissues. Rhesus macaques may be used as a model of aerosol infection that will allow the development of lifesaving medical countermeasures under the Food and Drug Administration’s animal rule.
Getting Leukocytes to the Site of Inflammation

There is no “response” in either the innate or adaptive immune response unless leukocytes cross blood vessels. They do this through the process of diapedesis, in which the leukocyte moves in ameboid fashion through tightly apposed endothelial borders (paracellular transmigration) and in some cases through the endothelial cell itself (transcellular migration). This review summarizes the steps leading up to diapedesis, then focuses on the molecules and mechanisms responsible for transendothelial migration. Surprisingly, many of the same molecules and mechanisms that regulate paracellular migration also control transcellular migration, including a major role for membrane from the recently described lateral border recycling compartment. A hypothesis that integrates the various known mechanisms of transmigration is proposed.
Revision of failed syndesmotic fixation with a suture button device: report of two cases

D isruption of the syndesmosis can be associated with a broad spectrum of external rotation injuries to the ankle. The syndesmosis is an important contributor to ankle stability, and if injury goes unrecognized or untreated it can have consequences leading to long-term disability of the ankle. We present two patients with external rotation ankle injuries with syndesmotic disruption who were initially treated with syndesmotic stabilization by placement of stainless steel screw implants and subsequently required revision because of early postoperative syndesmotic diastasis and fixation failure. The ankles were revised with a suture-button implant (Tightrope, Arthrex, Naples, Fla.), which successfully maintained reduction of the syndesmosis throughout treatment.