Miracle-dz/UniFAR-FTUs huggingface dataset:
Specific Threats Would an Obese Person Whistle Vivaldi ? Targets of Prejudice Self-Present to Minimize Appearance of

How do targets of stigma manage social interactions? We built from a threat-specific model of prejudice to predict that targets select impression-management strategies that address the particular threats other people see them to pose. We recruited participants from two groups perceived to pose different threats: overweight people, who are heuristically associated with disease and targeted with disgust, and Black men, who are perceived to be dangerous and targeted with fear. When stereotypes and prejudices toward their groups were made salient, overweight people (Studies 1 and 2) and Black men (Study 2) selectively prioritized self-presentation strategies to minimize apparent disease threat (wearing clean clothes) or physical-violence threat (smiling), respectively. The specific threat a group is seen to pose plays an important but underexamined role in the psychology of being a target of prejudice.
Structure–function relationships in HIV‐1 Nef

The accessory Nef protein of HIV and SIV is essential for viral pathogenesis, yet it is perplexing in its multitude of molecular functions. In this review we analyse the structure–function relationships of motifs recently proposed to play roles in aspects of Nef modification, signalling and trafficking, and thereby to impinge on the ability of the virus to survive in, and to manipulate, its cellular host. Based on the full‐length structure assembly of HIV Nef, we correlate surface accessibility with secondary structure elements and sequence conservation. Motifs involved in Nef‐mediated CD4 and MHC I downregulation are located in flexible regions of Nef, suggesting that the formation of the transient trafficking complexes involved in these processes depends on the recognition of primary sequences. In contrast, the interaction sites for signalling molecules that contain SH3 domains or the p21‐activated kinases are associated with the well folded core domain, suggesting the recognition of highly structured protein surfaces.
Design of minimum-phase digital filters as the sum of two allpass functions using the cepstrum technique

A new and practical approach using the cepstrum technique is proposed in the design of minimum-phase digital filters as the sum of two allpass functions. The desired magnitude response is specified in the frequency domain. Its corresponding minimum-phase response is then obtained from the desired magnitude response. The desired phases for the two allpass filters are obtained from the magnitude and phase responses. For both filters to be stable, the corresponding denominator polynomials are minimum phase. The filter coefficients are obtained from the desired phases using the cepstrum technique. Design examples show that the method works well for both classical filter specification and general magnitude specification in the frequency domain.
Home safety measures and the risk of unintentional injury among young children: a multicentre case–control study

Background: Young children may sustain injuries when exposed to certain hazards in the home. To better understand the relation between several childproofing strategies and the risk of injuries to children in the home, we undertook a multicentre case–control study in which we compared hazards in the homes of children with and without injuries. Methods: We conducted this case-control study using records from 5 pediatric hospital emergency departments for the 2-year period 1995–1996. The 351 case subjects were children aged 7 years and less who presented with injuries from falls, burns or scalds, ingestions or choking. The matched control subjects were children who presented during the same period with acute non-injury-related conditions. A home visitor, blinded to case-control status, assessed 19 injury hazards at the children's homes. Results: Hazards found in the homes included baby walkers (21% of homes with infants), no functioning smoke alarm (17% of homes) and no fire extinguisher (51% of homes). Cases did not differ from controls in the mean proportion of home hazards. After controlling for siblings, maternal education and employment, we found that cases differed from controls for 5 hazards: the presence of a baby walker (odds ratio [OR] 9.0, 95% confidence interval [CI] 1.1–71.0), the presence of choking hazards within a child's reach (OR 2.0, 95% CI 1.0–3.7), no child-resistant lids in bathroom (OR 1.6, 95% CI 1.0–2.5), no smoke alarm (OR 3.2, 95% CI 1.4–7.7) and no functioning smoke alarm (OR 1.7, 95% CI 1.0–2.8). Interpretation: Homes of children with injuries differed from those of children without injuries in the proportions of specific hazards for falls, choking, poisoning and burns, with a striking difference noted for the presence of a baby walker. In addition to counselling parents about specific hazards, clinicians should consider that the presence of some hazards may indicate an increased risk for home injuries beyond those directly related to the hazard found. Families with any home hazard may be candidates for interventions to childproof against other types of home hazards.
Speech Emotion Recognition using GFCC and BPNN

From the past years, researchers have showed a very interest in the speech recognition systems based on the emotions. Mainly the research has been done with the aim to bring closer both human and computer with each other by recognizing mood swings. In the recognizing process we must know how to represent the emotions on the basis of some features like sad, happy etc. When the verbal content is well recognized on the speaker's emotion, a promising enhancement of such systems would come. So recognition in speech is a crucial step. In the proposed work speech emotions will be recognized using hybridization of GFCC (Gammatone Frequency Cepstral Coefficients) and BPNN (Back Propagation Neural Network). The whole simulation will be done in the MATLAB environment to check the comparison result.
Purification and Characterization of Cellobiose Dehydrogenase from White-Rot Basidiomycete Trametes hirsuta

In order to save energy during the pulp making process, we tried to use white-rot basidiomycete, Trametes hirsuta, which degrades lignin efficiently. But a decrease in paper strength caused by cellulolytic activity ruled this out for practical application. Since the cellulolytic activity of the fungus must be decreased, we purified and characterized a cellobiose dehydrogenase (CDH) that was reported to damage pulp fiber. The CDH in the culture filtrate of C. hirsutus was purified by freeze-thawing and chromatographic methods. The pI of the enzyme was 4.2 and its molecular weight was 92 kDa. The optimal temperature and pH of the enzyme were 60–70 °C and 5.0 respectively. Since the purified CDH decreased the viscosity of pulp in the presence of Fe(III) and cellobiose, it was shown that the suppression of CDH should be an effective way to reduce cellulose damage.
Involvement of p53 in oroxylin A‐induced apoptosis in cancer cells

Oroxylin A, a naturally occurring monoflavonoid extracted from Scutellariae radix, exhibits anticancer activity and induces apoptosis in human hepatocellular carcinoma HepG2 cells according to our previous data. In this study, we investigate whether p53 is involved in oroxylin A‐triggered viability inhibition and apoptosis induction in cancer cells. In a panel of different cancer cell lines, more potent inhibitory effects of oroxylin A were observed in wtp53 cells than those in mtp53 or p53‐null cells. Moreover, p53‐siRNA‐transfected HepG2 cells showed lower levels of apoptosis induced by oroxylin A than control‐siRNA‐transfected cells. Likewise, after oroxylin A treatment, p53‐null K‐562 cells displayed promoted apoptosis rate when transfected with wtp53 plasmid. Western blot and real‐time RT‐PCR assay revealed that oroxylin A markedly upregulated p53 protein expression in HepG2 and p53‐overexpressing K‐562 cells, but had no influence on p53 mRNA synthesis. Furthermore, after co‐treatment with cycloheximide, oroxylin A still exerted a little effect on p53 expression. The negative regulator of p53, MDM2 protein was detected, and downregulated expression was observed. In the presence of MG132, an inhibitor of proteasome‐mediated proteolysis, no change in p53 expression was obtained. Additionally, the antioxidant N‐acetyl‐L‐cysteine could obviously abrogate p53 stabilization triggered by oroxylin A. Therefore, it is summarized that oroxylin A stabilized p53 expression and induced apoptosis at the posttranslational level via downregulating MDM2 expression and interfering MDM2‐modulated proteasome‐related p53 degradation. This indicated that oroxylin A could be served as a potential, novel agent candidate for cancer therapy. © 2009 Wiley‐Liss, Inc.
Fatores de risco para a suspeita de atraso do desenvolvimento neuropsicomotor aos 24 meses na coorte de nascimentos de 2004 em Pelotas

Objetivo: Identificar os fatores de risco para suspeita de atraso do desenvolvimento neuropsicomotor (ADNPM), aos 2 anos de idade, em todas as criancas nascidas no ano de 2004 em Pelotas. Metodos: Estudo realizado na Coorte de Nascimentos de Pelotas de 2004, atraves da aplicacao do Battelle Screening Developmental Inventory (BSDI), aos 2 anos de idade. Foi proposto um modelo hierarquico de determinacao de ADNPM, para ajuste de fatores de confusao, compreendendo caracteristicas socio-demograficas, reprodutivas e gestacionais maternas, bem como caracteristicas da crianca e de estimulo ambiental. A analise ajustada foi conduzida por meio de regressao de Poisson. Resultados: Nas 3869 criancas estudadas, 3,3% apresentaram BSDI positivo. Apos controle para fatores de confusao, as criancas com maior probabilidade de apresentar suspeita de ADNPM foram: as que tiveram BSDI positivo aos 12 meses (RP= 5,51 IC95% 3,59-8,47); Apgar < 7 no 5o minuto (RP= 3,52 IC95%1,70-7,27 ); filhas de maes com escolaridade < 4 anos (RP= 3,35 IC95% 1,98-5,66); de familias das classes sociais D e E (RP= 3,00 IC95% 1,45-6,19); com historia de diabetes gestacional RP= 2,77 IC95% 1,34-5,75); intervalo interpartal < 24 meses (RP= 2,46 IC95% 1,42-4,27); nao ouvir historias infantis na ultima semana (RP 2,28 IC95% 1,43-3,63); ausencia de literatura infantil em casa (RP=2,08 IC95% 1,27-3,39); BPN (RP=1,75 1,00-3,07); prematuridade (RP 1,74 IC95%1,07-2,81 ); < 6 consultas pre-natais (RP= 1,70 IC95% 1,07-2,68); historia de hospitalizacoes (RP=1,65 IC95% 1,09-2,50); e sexo masculino (RP= 1,43 IC95% 1,00-2,04). Conclusao: Foram identificados fatores de risco que podem ser alvo de politicas publicas, bem como auxiliar a pratica dos Pediatras para prevencao do ADNPM.
FATIGUE, INSUFFICIENCY, AND PATHOLOGIC FRACTURES.

A partial or complete fracture which results from the inherent inability of bone to withstand stress applied without violence in a rhythmical, repeated, subthreshold manner is a "stress fracture. " Because numerous terms have been used in the medical literature to designate the two types of stress fractures, the following classification is recommended. A "fatigue fracture" occurs when abnormal stress is applied to bone with normal elastic resistance. An "insufficiency fracture" is produced by normal or physiological stress applied to bone with deficient elastic resistance. Fatigue and insufficiency fractures occur most frequently in the weight-bearing bones. The term "pathologic fracture" should be limited to any fracture in bone weakened by tumor.
The Epidemiology of Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis in Olmsted County, Minnesota

To estimate the annual incidence, prevalence, and mortality of antineutrophil cytoplasmic autoantibody (ANCA)–associated vasculitis (AAV) and its subsets, granulomatosis with polyangiitis (Wegener's) (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (Churg‐Strauss) (EGPA), in a US‐based adult population.
Connectivity is Ubiquitous, But is It Beneficial? A Numerical Approach to Assess Individuals' Valuations of Smart Home Systems

Digitization of everyday products and individual compositions of complex systems foster technological home networks. Thereby, users decide which smart home systems (SHS) they wish to connect themselves. Despite this phenomenon's increasing relevance, previous research has not yet analyzed how individuals buy and combine systems for home network integration. Existing approaches do not consider the additional utility from connecting systems within home networks. Thus, we extend network effect theory with a user-centered view and formalize SHS valuation based on utility effects created by users' independent decisions to connect. Our model presents a comprehensive and outright way of system valuation and selection, and accounts for current connectivity benefits in home networks. Based on combinatory optimization, we derive optimal home network compositions and underline the influences of network size and density. These findings on decision behavior are critical for providers to assess the utility of their products and to tweak system configurations accordingly.
Relación entre horas de sueño y síndrome metabólico

Antecedentes: el sindrome metabolico es un grupo de factores de riesgo interrelacionados que incrementan el riesgo cardiovascular. Aun es incierto si este grupo resulta de multiples factores de riesgo subyacente o es una causa unica. Las demostraciones sugieren que la restriccion del sueno afecta adversamente al metabolismo. La restriccion del sueno puede danar la tolerancia a la glucosa, alterar las concentraciones de leptina y grelina e incrementar el hambre y apetito, sobre todo para alimentos con alto contenido de carbohidratos que, a su vez, aumentan el sindrome metabolico. Objetivo: evaluar la relacion entre horas de sueno, los componentes del sindrome metabolico y el papel de guardia ABC, entre los residentes de dos instituciones de salud. Metodo: estudio de casos y controles realizado en dos instituciones de salud, entre los meses de abril y mayo del 2008, con base en los criterios del Tercer Informe Nacional del Programa de Educacion en Colesterol (NCEP-ATP III). Participaron 65 residentes de segundo ano o mas, 33 con guardias ABC de la Secretaria de Salud del Gobierno del Distrito Federal, y 32 de especialidades sin esta practica medica complementaria del Hospital General de Mexico. A cada residente se le informaron las caracteristicas y los objetivos del estudio; luego de su aceptacion se recolecto la informacion por medio de una cedula. Se determinaron: la presion arterial, circunferencia de cintura, peso, talla e IMC. Se extrajo sangre en ayuno (de al menos ocho horas) para determinar las concentraciones de glucosa, colesterol HDL, trigliceridos e insulina. Resultados: con menos de cinco como con mas de ocho horas de sueno al dia se encontro mayor susceptibilidad a padecer sindrome metabolico. El estado de salud metabolico encontrado en los residentes fue: obesidad IMC > 27, la incidencia global fue de 40%, 54.5 y 25% en el grupo expuesto y no expuesto, RM de 3.86 (IC 95% de 1.31 a 11.46) p= 0.01. Concentra
A science of the individual: implications for a medical school curriculum.

This observation was made by observers of the past who saw that because there was no science of the individual, there was no way to treat a patient as an individual. It is not clear what they thought that science of the individual was, but we know what it is today. It is the uniqueness of the individual—genetic, developmental, and experiential—that accounts for human variation, whether in health or disease.
CFTR and Bicarbonate Secretion to Epithelial Cells

Defective HCO3– and fluid secretion are hallmarks of the pathophysiology of the pancreas of cystic fibrosis patients. Recently, impaired HCO3– secretion has been shown in most tissues known to express the cystic fibrosis transmembrane conductance regulator (CFTR). New results suggest that CFTR plays an important role in the transcellular secretion of HCO3–.
ZFP423 Coordinates Notch and Bone Morphogenetic Protein Signaling, Selectively Up-regulating Hes5 Gene Expression*

Zinc finger protein 423 encodes a 30 Zn-finger transcription factor involved in cerebellar and olfactory development. ZFP423 is a known interactor of SMAD1-SMAD4 and of Collier/Olf-1/EBF proteins, and acts as a modifier of retinoic acid-induced differentiation. In the present article, we show that ZFP423 interacts with the Notch1 intracellular domain in mammalian cell lines and in Xenopus neurula embryos, to activate the expression of the Notch1 target Hes5/ESR1. This effect is antagonized by EBF transcription factors, both in cultured cells and in Xenopus embryos, and amplified in vitro by BMP4, suggesting that ZFP423 acts to integrate BMP and Notch signaling, selectively promoting their convergence onto the Hes5 gene promoter.
Confusing Psychosis With Imagination The Best of T imes , the Worst of T imes : 2017

I n 1934, the writer James Joyce sought treatment for his severely disturbed daughter, Lucia, and brought her to Dr. Carl Jung for an analysis. (Soon after, Lucia received a diagnosis of schizophrenia at the Burghölzli psychiatric clinic in Zurich.) James Joyce saw a direct connection between his own creative genius and his daughter’s illness. “Whatever spark or gift I possess has been transmitted to Lucia,” Joyce told Jung, “and it has kindled a fire in [Lucia’s] brain. ” But Jung perceived an important distinction between father and daughter. He described them as “two people going to the bottom of a river, one falling and the other diving. ” I believe Jung was getting at a crucial distinction: that between the involuntary nature of psychosis (“falling”) and the voluntary act of the creative imagination (“diving”). All this comes to mind in light of an op-ed by Mark Lukach that recently appeared in the New York Times. Lukach gives a poignant account of his wife’s multiple episodes of psychosis, which—eerily enough—tend to recur
Comparative and joint prediction of DUI recidivism from alcohol ignition interlock and driver records.

OBJECTIVE This work was conducted to find practical predictors that anticipate which driving under the influence (DUI) offenders will continue to drink and drive after a period of alcohol ignition interlock-controlled driving ends. The interlock prevents impaired driving by requiring a low blood alcohol concentration (BAC) breath sample before allowing an engine to start. Each breath test is recorded. The study evaluated the interlock record as a predictor of future DUI offenses relative to driver records and self-report items. METHOD Subjects were 2,273 DUI offenders in Alberta, Canada, who used an interlock to gain full reinstatement of driving privileges; for 2,134, the installed periods ranged from 5 to 30 months. A median of 8.1 breath tests was logged for each installed day; 9.9 tests were taken on each day of vehicle use (4.3 starts plus 5.6 running retests). Predictors of postinterlock repeat DUI were compared by sensitivity and survival analyses. RESULTS Although 69% of all interlock users had at least one BAC test > or = . 04% (a "fail" test) within the first 5 months, only 9% were reconvicted up to 4 years after interlock removal. Failed interlock tests proportional to all BAC tests taken was the best predictor of driver recidivism risk during the years following interlock removal. CONCLUSION The interlock record provides new information, particularly about drivers with no prior DUI offenses. Prior moving violations and driving while suspended convictions, although better predictors than questionnaire data, were poorer than interlock records and prior DUI offenses. The alcohol interlock, already recognized as a useful control device, warrants attention for DUI prediction as well.
Endometriosis and Inflammation in Infertility

Abstract: A wealth of publications proposes that endometriosis and inflammation may have an unfavorable influence on fertility. A recent meta‐analysis of assisted reproductive technologies demonstrated that, once confounding factors are controlled for, the pregnancy rate in women with endometriosis is approximately 50% of the rate of women with tubal factor infertility. Peritoneal fluid of women with endometriosis contains elevated amounts of macrophages and their secreted products, such as growth factors, cytokines, and angiogenic factors. Because reproductive organs are bathed in and thus will be influenced by peritoneal fluid, these proinflammatory mediators would affect various aspects of reproduction in women with endometriosis. Advanced stages of endometriosis may have easily understandable factors, such as distortion of the anatomy, causing infertility. On the other hand, in minimal or mild endometriosis mechanisms underlying reproductive failure are subtle and remain controversial. Recent reports suggest that inflammatory factors play a role in this endometriosis‐associated reproductive failure. This review provides an overview of recent data on the effects of endometriosis‐associated inflammation on fertility.
Misogyny and idealization in the courtly romance

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Evaluation of cardiovascular risk factors in overweight and obese subjects.

Twenty obese subjects (Males = 8, Females = 12; average age = 39.5 +/- 2.5 years; B.M.I. = 36.2 +/- 2.5), 20 overweight subjects (Males = 8, Females = 12; average age = 38.5 +/- 2 years; B.M.I. = 28.8 +/- 0.4) and 20 non obese healthy subjects as controls, matched for sex and age (Males = 8, Females = 12; average age = 37.5 +/- 2 years; B.M.I. = 22.4 +/- 0.8) were selected. We determined: blood glucose, triglycerides, total cholesterol, HDL-cholesterol, Apolipoproteins A1 and B, Factor VII, fibrinogen and plasminogen. Before and after a venous occlusion test were also measured: t-PA Antigen, PAI activity and haematocrit. Metabolic, coagulative and fibrinolytic pathological changes were observed in overweight and obese subjects and the interaction of these risk factors may contribute to the pathogenesis of atherosclerosis vascular disease and to the high rate of thromboembolic events reported in obesity.