Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Syzygium cumini Seed Extract on the Memory Loss of Alzheimer’s Disease Model Rats

Alzheimer’s disease (AD) is the most prominent dementia-related disease and characterized by the presence of insoluble amyloid beta peptide (Aβ) fibers in or around the brain neurons of the affected person. Therefore, agent(s) capable of inhibiting brain amyloid deposition might delay the occurrence or retard the progress forwards of AD and related neurobehavioral symptoms. Here, we report whether, chronic oral administration of Syzygium cumini (locally known as Jam)-seed extract exerts protection against the progressive cognitive decline in the Aβ1-40-infused AD model rats. After 12 weeks of feeding with S. cumini seed extract (at 300 mg/kg BW), we evaluated the learning-related memory of the rats by 8-arm radial maze task, where we determined two types of memory errors, namely reference memory errors (RMEs) and working memory errors (WMEs). After completion of memory tests, rats were sacrificed and the levels of lipid peroxide (LPO), the Aβ1-40-burden, Aβ1-40-oligomers, proinflammatory TNFα, brain derived neurotrophic factor (BDNF), Tyrosine-kinase B (TrkB), postsynaptic-density protein 95 (PSD-95) and Synapse-associated protein (SNAP-25) were determined in the corticohippocampal tissues of the brain. In addition, in vitro antioxidative effects of S. cumini seed extract were evaluated. The oral administration of S. cumini extract significantly increased the memory-related learning ability of the AD model rats, concomitantly with reductions in the levels of corticohippocampal Aβ1-40-burden and Aβ1-40-oligomers. Furthermore, the extract suppressed the levels of TNFα and LPO in the corticohippocampal tissues of the AD rats and also the later in the plasma, suggesting an anti-oxidative and anti-inflammatory activities of the S. cumini extract in the brains of AD model rats. S. cumini extract also increased the levels of brain cognition and memory-related proteins, including BDNF, TrKB, PSD-95 and SNAP-25. We thus suggest that S. cumini-seed extract could be used in neurobehavioral deficits and associated pathogenesis of Alzheimer’s disease.
A Photo-Based Augmented Reality System with Low Computational Complexity

In this report, we propose an augmented reality (AR) system using photo images. Based on the position and orientation of the user’s camera, the system selects the most appropriate image of an object from a set of photos taken at various angles and “pastes” it into the camera image at an appropriate location and scale. Since the technique requires no 3D model creation or 3DCG rendering during the AR processes, it is well suited to mobile devices with limited power and rendering capacity. The proposed system is also installed and evaluated on a practical device.
Statistics and dynamics of the boundary layer reattachments during the drag crisis transitions of a circular cylinder

Time series of pressure measured on the periphery of the central section of a circular cylinder of aspect ratio 22 are used to investigate the dynamics of the local reattachments during the drag crisis transitions. A succession of multi-stable dynamics are identified and characterized through conditional statistical analysis as the Reynolds number is increased. The first transition marking an abrupt weakening of the periodic pressure fluctuations associated to the global shedding dynamics is accompanied by the appearance of symmetric and bistable perturbations. Afterwards, two scenarii of asymmetric and symmetric boundary layer reattachments are found. The asymmetric scenario leads to two transitions. During the first transition, the flow explores randomly three stable states to eventually stabilize on the state corresponding to the permanent reattachment on one side of the cylinder. The second transition is bistable and leads to the permanent reattachment on both sides. For the second symmetric scenario, the boundary layer reattachments occur simultaneously on both side of the cylinder. In that case, the flow explores randomly two stable states to eventually stabilize on the state of full reattachment. Pressure distributions of all of these states are characterized as well as their corresponding probabilities during the drag crisis transitions of the critical regime.
Systematic Characterization of the Molecular Mechanisms That Regulate and Mediate Alternative Lengthening of Telomeres in Breast Carcinoma

Abstract : Alternative lengthening of telomeres (ALT) is a mechanism utilized by several cancer types to maintain telomeres. The aim of this project is to characterize the mechanisms that mediate and regulate ALT activity in breast cancer, by utilizing proteomic and genomic approaches to describe and perturb ALT+ cells. Gaining this knowledge on ALT activity can promote the development of novel treatment for ALT+ breast tumors, and patients with telomerase inhibitor resistant tumors, while having minimal non-desired effects on the normal cell population that typically has no ALT activity. Here, I report on my progress in profiling the global transcriptional patterns that differentially characterize ALT+ cells. I describe the analytical tools that I used to define an ALT-related gene signature, and my efforts to identify potential functional relationship to ALT activity.
GCOE Discussion Paper Series Global COE Program Human Behavior and Socioeconomic Dynamics

This paper presents a politico-economic model that includes a mutual link between life cycle earnings mobility and redistributive politics. The model demonstrates that when an economy features a high opportunity of upward mobility and high risk of downward mobility, it attains a unique equilibrium where unskilled, low-income agents support a low redistribution because of the hope of upward mobility in future. In contrast, the economy attains multiple equilibria when mobility opportunity and risk are low: one is an unskilled-majority equilibrium defined by low mobility and the other is a skilled-majority equilibrium defined by high mobility. The paper gives a comparison between the political equilibrium and the social planner’s allocation in terms of mobility, and shows that the skilled-majority equilibrium realizes mobility close to the optimal one.
Effects of potassium aluminum sulfate on TNF-α, MMP-1 and MMP-8 levels at gingival crevicular fluid in periodontally healthy subjects: a pilot study

Objectives: The aim of this study was to investigate the possible effects of fixed dental prosthesis procedures with and without gingival retraction containing potassium aluminum sulfate on TNF-α, MMP -1 and MMP-8 levels at gingival crevicular fluid in periodontally healthy subjects and to demonstrate that these markers can be used for the assessment of disease activity. Methods: Eight healthy subjects, each with at least two abutment teeth, were included in our research. Gingival crevicular fluid (GCF) samples were obtained before initiation of fixed dental prosthesis treatment and repeated on days 2, 3, 7 and first month after cementation. GCF concentrations of MMP-1, MMP-8 and TNF-α were determined by ELISA. ANOVA was used for statistical analysis. Results: The GCF MMP-8 concentrations revealed significant differences among study groups (p 0.05). The MMP-8 concentrations of control group was significantly decreased in the first month (p<0.05). The TNF-α concentrations showed significant differences in all study groups (p<0.05). In contrast to ret(-) and control groups, TNF-α concentrations of ret(+) group was significantly different among sampling days (p<0.05). The TNF-α concentration peaked in the first month in ret(+) group. Conclusion: Within the scope of this study, it may be suggested that well-fitted fixed dental prosthesis and its procedures performed to periodontally healthy subjects do not affect the periodontal tissue health negatively.
Crosstalk among interleukin 23 and DNAX activating protein 12-dependent pathways promotes osteoclastogenesis

Interleukin 23 (IL-23) has been well studied in the context of T cell differentiation, however, its role in the differentiation of myeloid progenitors is less clear. In this paper we describe a novel role of IL-23 in myeloid cell differentiation. Specifically, we have identified that in human peripheral blood mononuclear cells IL-23 induces the expression of MDL-1 a PU.1 transcriptional target during myeloid differentiation, which orchestrates osteoclast differentiation through activation of DAP12 and its immunoreceptor tyrosine activation motifs (ITAM’s). The molecular events that lead to the differentiation of human macrophages to terminally differentiated osteoclasts are dependent on SYK and PLCγ2 phosphorylation for the induction of intracellular calcium flux and the subsequent activation of master regulator osteoclast transcription factor nuclear factor of activated T cells cytoplasmic 1 (NFATc1). IL-23 elicited osteoclastogenesis is independent of the RANKL pathway and utilizes a unique MDL-1+/DAP12+ cell subset. Our data define a novel pathway that is utilized by IL-23 in myeloid cells and identify a major mechanism for the stimulation of osteoclastogenesis in inflammatory arthritis.
U.S. DEPARTMENT OF THE INTERIOR U.S. GEOLOGICAL SURVEY

+23 M STAGE 11 SEA-LEVEL IN SOUTHERN BRITIAN -D.Q. Bowen MARINE ISOTOPIC STAGE 11 HIGH SEA LEVEL RECORD FROM NORTHWEST ALASKA -Julie Brigham-Grette OXYGEN ISOTOPE STAGE 11 IN SOUTHERN OCEAN SEDIMENTS -Lloyd Burckle OXYGEN ISOTOPE STAGE 11; AN ANALOG FOR FUTURE CLIMATE CHANGE? -Lloyd Burckle MARINE ISOTOPE STAGE 11 IN THE SOUTH ATLANTIC SECTOR OF THE SOUTHERN OCEAN -David A. Hodell THE MARINE RECORD OF THE MIS 11 OSCILLATION -W. R. Howard DATING OF GLACIAL TERMINATION V AND DURATION OF THE STAGE 11 HIGHSTAND -Daniel B. Karner, Fabrizio Marra, and Paul R. Renne A PALEOCEANOGRAPHIC INTERPRETATION FOR A MIDDLE PLEISTOCENE INTERGLACIAL BASED ON MICROPALEONTOLOGY AND OSTRACODE MG/CA SHELL CHEMISTRY, ARCTIC COASTAL PLAIN, ALASKA -D. A. Korejwo and J. Brigham-Grette
A comparison and analysis of different PDE-based approaches for image enhancement

In this paper, we have compared three recently developed techniques for image enhancement and denoising. These methods are based on the use of partial differential equations, including second order, fourth order, and the complex partial differential. We consider various well-known measuring metrics used in image processing applied to standard images in this comparison. In this study, it is shown that the capability of the PDE-based approaches depends highly on the neighboring structure. Our investigations show that in an image where the energy of noise is low, the complex diffusion method offers a better result in image denoising compared to other methods. However, when the energy of the noise increases, performance of the complex diffusion method declines. In general, for the case when the energy of noise in an image is unpredictable, using the heat equation for image denoising is recommended.
A DSP EMBEDDED OPTICAL NAVIGATION SYSTEM A Thesis by KIRAN KUMAR GUNNAM Submitted to Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved as to style and content by:

A DSP Embedded Optical Navigation System. (May 2003) Kiran Kumar Gunnam, B.Tech., Jawaharlal Nehru Technological University Co-Chairs of Advisory Committee: Dr. John L. Junkins Dr. Nasser Kehtarnavaz Spacecraft missions such as spacecraft docking and formation flying require high precision relative position and attitude data. Although Global Positioining Systems can provide this capability near the earth, deep space missions require the use of alternative technologies. One such technology is the vision-based navigation (VISNAV) sensor system developed at Texas A&M University. VISNAV comprises an electro-optical sensor combined with light sources or beacons. This patented sensor has an analog detector in the focal plane with a rise time of a few microseconds. Accuracies better than one part in 2000 of the field of view have been obtained. This research presents a new approach involving simultaneous activation of beacons with frequency division multiplexing as part of the VISNAV sensor system. In addition, it discusses the synchronous demodulation process using digital heterodyning and decimating filter banks on a low-power fixed point DSP, which improves the accuracy of the sensor measurements and the reliability of the system. This research also presents an optimal and computationally efficient six-degree-of-freedom estimation algorithm using a new measurement model based on the attitude representation of Modified Rodrigues Parameters.
Variability of unusual distributions of alkenones in the surface waters of the Nordic seas

[1] Samples of filtered particulate organic matter (POM) were obtained during the summers of 1999 and 2000 from the surface waters of the Nordic seas to monitor the spatial distribution of long-chain alkenones. The aim of the study was to appraise existing alkenone-based climatic proxies in northern high latitudes. Unusually high percentages of the tetraunsaturated alkenone were measured in the polar waters of the East Greenland Current, with C37:4 of up to 77% in 80% of sea-ice cover. Values of percent C37:4 across the Nordic seas showed a strong association with water mass type. Analysis of coccoliths in filters indicated that calcified Emiliania huxleyi could not be discounted as the biological precursor of alkenones in all the water masses. A combined data set of 69 samples of POM revealed a stronger correlation of percent C37:4 to sea surface salinity (SSS; R2 = 0.72) than to sea surface temperature (SST; R2 = 0.50). Values of percent C37:4 in sea surface POM were much higher than those in surficial sediments of the northern North Atlantic. To explain the discrepancy in sedimentary and surface water column percent C37:4, we propose that the alkenone contents in surface sediments underlying arctic and polar waters are a combination of autochthonous and allochthonous inputs of alkenones. Our results show that percent C37:4 can be used to reconstruct the relative extension of arctic/polar water masses in the North Atlantic. However, the results prevent confirmation of percent C37:4 as a paleo-SSS proxy in the Nordic seas, given its multivariate nature in our data set and the decoupling between its range of values in surface waters and sediments.
Passive seismic source location using group sparsity constrained two-way waveform inversion

Passive seismic source location plays an important role in the seismological community for it is commonly used in retrieving the epicenter of earthquakes and evaluating the effectiveness of hydraulic fracturing. Time reversal imaging is one of the most popular methods for source imaging. This method back-propagates seismic recordings into medium and focuses energy at source locations. However, events often can’t be fully focused leading to inadequate resolution of sources from a limited observing aperture. To solve this problem, this paper illustrate a source location method that adopts group sparsity constrained waveform inversion. This method can retrieve source locations and origin time simultaneously and the adopted group sparsity constraint is capable of yielding spatially sparse results while the source function is smooth in time axis .
The (Surprising) Efficacy of Academic and Behavioral Intervention with Disadvantaged Youth: Results from a Randomized Experiment in Chicago

There is growing concern that improving the academic skills of disadvantaged youth is too difficult and costly, so policymakers should instead focus either on vocationally oriented instruction for teens or else on early childhood education. Yet this conclusion may be premature given that so few previous interventions have targeted a potential fundamental barrier to school success: "mismatch" between what schools deliver and the needs of disadvantaged youth who have fallen behind in their academic or non-academic development. This paper reports on a randomized controlled trial of a two-pronged intervention that provides disadvantaged youth with non-academic supports that try to teach youth social-cognitive skills based on the principles of cognitive behavioral therapy (CBT), and intensive individualized academic remediation. The study sample consists of 106 male 9th and 10th graders in a public high school on the south side of Chicago, of whom 95% are black and 99% are free or reduced price lunch eligible. Participation increased math test scores by 0.65 of a control group standard deviation (SD) and 0.48 SD in the national distribution, increased math grades by 0.67 SD, and seems to have increased expected graduation rates by 14 percentage points (46%). While some questions remain about the intervention, given these effects and a cost per participant of around $4,400 (with a range of $3,000 to $6,000), this intervention seems to yield larger gains in adolescent outcomes per dollar spent than many other intervention strategies.
Complex algebraic plane curves via Poincaré--Hopf formula. III. Codimension bounds

This work is a continuation of the papers [BZ1] and [BZ2]. Here we prove some estimates for the sum of codimensions of singularities of aﬃne planar rational curves. Acknowledgements. We want to thank Mariusz Koras, Zbigniew Je-lonek, Stepan Orevkov and Peter Russell for their interest in our work and interesting discussions.
Managing seagrasses for resilience to climate change

There is growing evidence that seagrasses are experiencingdeclines globally due to anthropogenicthreats (Short and Wyllie-Echeverria 1996, Duarte2002, Orth et al. 2006). Runoff of nutrients andsediments that affect water quality is the greatestanthropogenic threat to seagrass meadows,although other stressors include aquaculture, pollution,boating, construction, dredging and landfillactivities, and destructive fishing practices. Naturaldisturbances such as storms and floods canalso cause adverse effects. Potential threats fromclimate change include rising sea levels, changingtidal regimes, UV radiation damage, sedimenthypoxia and anoxia, increases in sea temperaturesand increased storm and flooding events.Thus, seagrass meadows, the ecosystems thatthey support and the ecosystem services that theyprovide are threatened by a multitude of environmentalfactors that are currently changing or willchange in the future.Seagrasses are flowering plants that thrive in shallowoceanic and estuarine waters around the world.Descendants of terrestrial plants that re-enteredthe ocean between 100 and 65 million years ago,seagrasses have leaves, stems, rhizomes (horizontalunderground runners) and roots. Althoughthere are only about 60 species of seagrassesworldwide, these plants play an important role inmany shallow, near-shore, marine ecosystems.Seagrass meadows provide ecosystem servicesthat rank among the highest of all ecosystems onearth. The direct monetary outputs are substantialsince highly valued commercial catches suchas prawns and fish are dependent on these systems.Seagrasses provide protective shelter formany animals, including fish, and can also be adirect food source for manatees and dugongs,turtles, water fowl, some herbivorous fish and seaurchins. The roots and rhizomes of seagrassesalso stabilise sediments and prevent erosion whilethe leaves filter suspended sediments and nutrientsfrom the water column. Seagrass meadowsare thus linked to other important marine habitatssuch as coral reefs, mangroves, salt marshes andoyster reefs.This paper presents an overview of seagrasses,the impacts of climate change and other threats toseagrass habitats, as well as tools and strategiesfor managers to help support seagrass resilience.
A Novel Background Subtraction Algorithm for Person Tracking Based on K-NN

Object tracking can be defined as the process of detecting an object of interest from a video scene and keeping track of its motion, orientation, occlusion etc. in order to extract useful information. It is indeed a challenging problem and it’s an important task. Many researchers are getting attracted in the field of computer vision, specifically the field of object tracking in video surveillance. The main purpose of this paper is to give to the reader information of the present state of the art object tracking, together with presenting steps involved in Background Subtraction and their techniques. In related literature we found three main methods of object tracking: the first method is the optical flow; the second is related to the background subtraction, which is divided into two types presented in this paper, and the last one is temporal differencing. We present a novel approach to background subtraction that compare a current frame with the background model that we have set before, so we can classified each pixel of the image as a foreground or a background element, then comes the tracking step to present our object of interest, which is a person, by his centroid. The tracking step is divided into two different methods, the surface method and the K-NN method, both are explained in the paper. Our proposed method is implemented and evaluated using CAVIAR database.
Evaluation of the articulatory characteristics of voice in cochlear implanted children

Objective: To investigate the effect of cochlear implantation on articulation by using voice- onset time (VOT). Methods: At the first phase of this study, a total of 25 children without hearing loss were examined. VOT values of Turkish plosive consonants of /p/, /b/, /t/, /d/, /k/, /g/ specific to this age group were estimated, and their standardization was achieved. To this end, Kay Elemetrics CSL 4400 software (Key Elemetrics Ltd, Lincoln Park, NJ, USA) was used. Referencing these VOT values, 40 children ages ranging between 4 and 11 years who underwent cochlear implantation in our clinic were divided into six groups based on the duration of cochlear implantation, and VOT values were determined in these groups. These groups were compared within themselves, and with healthy children. Results: VOT values of consonants increased as the duration of cochlear implantation increased and approached to those of the children with normal hearing, and at the end of four years of cochlear implant use, they caught up with those of the normal hearing group. Conclusion: Our results have shown that early stage implantation, and use of implant for an adequate time period have a favorable impact on articulation in other words on comprehensibility of speech. We thought that VOT can be use in the evaluation of the effect of cochlear implant on the development of speech.
Preface to the 4th international workshop on multi-level modelling (MULTI 2017)

Traditional approaches to modelling systems tend to emphasize two-levels: type and instance. Recently, the benefits of meta-level access have been argued to be of importance in terms of language definition, particularly in terms of domainspecific languages. The ability to define elements at the metalevel improves the scope for abstraction, reuse, and ultimately system quality. Providing meta-level access introduces a number of methodological and technological challenges: how, and whether, to introduce strict separation between levels; how to express the relationships between elements at different levels; technologies for expressing multi-level concepts.