Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypertension secondary to primary hyperaldosteronism

Hypertension is a pandemic worldwide, being responsible for several cardiovascular, neurological and renal complications. The vast majority is due to essential or primary hypertension, but more and more cases of secondary arterial hypertension are diagnosed, either due to endocrinological, renal or neurological causes. Caso Clínico Hipertensión arterial secundaria a hiperaldosteronismo primario Hypertension secondary to primary hyperaldosteronism Nelson Rodrigo González González, Miguel Ferreira Bogado, Héctor Cano Arrieta 3 Rev. Nac. (Itauguá) 2019;11(1):116-123 10.18004/rdn2019.0011. 01.116-123 Next, an hypertension case of secondary to primary hyperaldosteronism is presented.
The Role of Government Capital Expenditures in Economic Growth in Jordan

This research aims at examining the role of government capital expenditures in economic growth in Jordan during the time period (1977-2016). The study collects the required data from the Central Bank of Jordan, the Department of Statistics, and the Ministry of Finance database. The analyzes is based on estimating the output as a function of input and control variables and analyzing the Gross Domestic Product (GDP) as a function of the total capital expenditures. The study found that first, the change in capital expenditures as a percentage of GDP has long-term equilibrium and has a short-term effect, but this result is unreliable due to model instability. Second, there is a short-term impact of net fixed capital formation and net tax on economic growth but there is no long-term equilibrium, and finally there is a short-term and long-term effect of government debt on economic growth. These findings can provide significant insights into many aspects of implementing policy in Jordan.
Prenatal stress induces long-lasting effects in lung glucocorticoid receptor gene expression in a sex-dependent manner

AIM: Stressful events during pregnancy may influence respiratory system development, resulting in long-term effects in the offspring. However, little is known on its long-lasting effects upon the expression of important genes in the lungs. Thus, we aimed to evaluate the effect of two different prenatal stress paradigms on lung glucocorticoid receptor (GR) expression in adulthood.METHODS: Pregnant BALB/c mice were divided into 3 groups: control (CON), prenatal stress from the second week of pregnancy (PNS1) and prenatal stress on the last week of pregnancy (PNS2). In both groups (PNS1 and PNS2), restraint stress was used. When adults, male and female offspring were submitted to 30 min of restraint stress. Lung gene expression of GR was evaluated.RESULTS: There was a significant increase in GR expression in males (PNS1), under basal conditions. Restraint stress during adulthood significantly reduced GR expression in PNS1 and PNS2 males as compared to controls. No significant differences were found for females.CONCLUSION: Results indicate that prenatal stress from the second week of gestation modulates adult male mice GR expression in the lungs. Thus, fetal exposure to maternal stress from the second week of gestation seems to modulate mechanisms responsible for pulmonary development in a sex-dependent manner.
Sentiment analysis of student responses related to information system services using Multinomial Naïve Bayes (Case study: Telkom University)

Current technological developments affect the types of information services provided, especially information system services that always related to the internet network. To improve existing services, user responses are needed regarding services provided, but if the response is very large, it will be difficult to know whether the services provided are good or not. By taking the right approach, the sentiment’s response can be analysed quickly and automatically. Sentiment analysis is done by classifying responses into positive and negative classes, the classification method is Multinomial Naïve Bayes (MNB). Before the data is known for the sentiments, the data is manually labeled, then the data goes through the preprocessing stage, cross validation, feature extraction and then sentiment classification with the MNB classifier. Classification process using MNB method on positive and negative responses, obtaining the highest negative response results in iGracias which is a detailed response of the information system sub-service by 44.27%. The MNB method using lemma with the conditions for preprocessing has a good average accuracy of 83.24% for information system sub-services and 79.24% for internet sub-services.
Ecology and conservation of the leatherback sea turtle (Dermochelys coriacea) nesting in Brazil

3 Acknowledgments . 4 Table of contents . 5 List of tables and figures . 6 Author’s declaration . 17 List of notations and abbreviations . 21 General introduction . 24 Chapter I: Thirty years of leatherback turtle (Dermochelys coriacea) nesting in Espírito Santo, Brazil, 1988-2017: reproductive biology and conservation . 34 Chapter II: Stable isotope analysis and satellite tracking of Southwestern Atlantic leatherback turtles (Dermochelys coriacea): habitat use and female-offspring relationships . 72 Chapter III: Estimating hatchling sex ratios of leatherback turtles (Dermochelys coriacea) in the Brazil . 115 Chapter IV: Assessing coastal artificial light and potential exposure of wildlife at a national scale: the case of marine turtles in Brazil . 162 Final remarks . 198 Conservation implications. 199 Future research. 201
Research Proposal NWO Open Competition 2008 1 Project data

for Laymen (in Dutch) Dit project ontwikkelt een verificatiemethode voor gegevensbescherming, één van de voorwaarden voor het garanderen van de veiligheid van hedendaagse applicaties. De technische innovatie die ten grondslag ligt aan dit voorstel is het begrip zelf-compositie, d.w. z. de mogelijkheid om een programma met zichzelf samen te stellen. Dit geeft de mogelijkheid om veiligheid van een programma uit te drukken
Markets, schools and the convertibility of economic capital: the complex dynamics of class choice

While economic capital is not synonymous with cultural, social or symbolic capital in either its constitutional or organizational form, it nevertheless remains the more flexible and convertible form of capital. The convertibility of economic capital has particular resonance within ‘Celtic Tiger’ Ireland. The state’s reluctance to fully endorse an internal market between schools has resulted in middle‐class parents using their private wealth to create an educational market in the private sector to help secure the class futures of their children. Using data from recent studies of second‐level education in Ireland, and data compiled on the newly emerging ‘grind’ schools (private tuition centres), we outline how the availability of economic capital allows middle‐class parents to choose fee‐paying schooling or to opt out of the formal school sector entirely to employ market solutions to their class ambitions. The data also show that schools actively collude in the class project to their own survival advantage.
Some sufficient conditions on Hamiltonian digraph

Z-mapping graph is a balanced bipartite graph $G$ of a digraph $D$ by split each vertex of $D$ into a pair of vertices of $G$. Based on the property of the $G$, it is proved that if $D$ is strong connected and $G$ is Hamiltonian, then $D$ is Hamiltonian. It is also proved if $D$ is Hamiltonian, then $G$ contains at least a perfect matching. Thus some existence sufficient conditions for Hamiltonian digraph and Hamiltonian graph are proved to be equivalent, and two sufficient conditions of disjoint Hamiltonian digraph are given in this paper.
Beef Cattle Supply Status with Recent Trends and Future Prospects in Relation to Past in the Cases of Mechara Town, West Hararghe, Oromia Regional State

This activity was conducted 2018 in Daro Labu, Mecahara town, West Hararghe Zone of Oromia National Regional State, Ethiopia. Data were collected from eight (8) butchers, ten (10) brokers and twenty (20) consumers of meat about cattle supply. According to the respondents, all of the cattle are local Hararghe breed. Most of the butchers (75%) did not participate in purchasing beef cattle rather than they used brokers for purchasing and only 25% of butchers purchase beef cattle by themselves. The supply status of beef cattle are depending on the season of the year:- which exceeds beyond requirement during holiday and time for paying cost of inputs like fertilizers and pesticides. 40% of the brokers responded that total cattle supply status is decreasing from time to time and about 60% of the respondents (brokers) responded that total cattle supply status is increasing from time to time in mechara town market. About 62.5% of the butchers have no any information about the relationship between butchery and beef cattle supply and have no worry about problems in counters them in the middle due to the shortage of beef cattle and only 37.5% of them have the information about the risk of associated beef cattle supply shortage. About 87.5% of the butchers responded that cattle supply status has been decreasing from year to year while 22.5% responded that there is no variation. All the butchery has known that animal age and breed type can affect both meat quality and quantity as well as marketability. About (87.5%) of butchers responded that they prefer at the age 4 - 6 years first followed by at the age of 2 - 4 years, thirdly they prefer at the of 6 - 8 years. No one slaughter below the age of 2 years and above of 8 years old. From this results, we observe that animals which are used for all butcheries are at the age of productive age and it needs special attention. All butchery (100%) of them have responded no one slaughter female animals (cow or heifer). Most butchers were responded that meat consumption habit increasing being they were joining the business even though the price of the meat dramatically increasing especially from Ethiopian Millennium to date. All the respondents agree that the price of the meat dramatically increasing. The average price when they started is 10 birr/kg and now a day's 240 birr/ kg.Out of 20 consumers, 80% of them were responded that demand for meat consumption is increasing from time to time even though meat quality is decreasing. All consumers agree that meat flavor is changed and have no sense of flavor due to two reasons: feed and pregnancy. Keywords : cattle supply, Mechara market, butcher, meat consumption, brokers DOI : 10.7176/JNSR/9-5-01 Publication date :March 31 st 2019
Chinese hamster ovary mutants for glycosylation engineering of biopharmaceuticals

The Chinese hamster ovary (CHO) cell has long been the cell of choice for the biopharmaceutical industry. The reasons for this are partly historical and partly because CHO cells produce glycoproteins with a glycan complement similar to that synthesized by human cells. The CHO-DUKX-B11 line was established early in the development of the biotechnology industry and has the advantage of allowing selection for high expression of transgenes. In addition, CHO cells glycosylate glycoproteins with a subset of glycans typical of human cells and essentially lacking antigenic sugar residues like α(1,3)Gal, β(1,2)xylose or N-glycolylneuraminic acid, typical of rodent or plant cells. In addition, CHO cells have a pseudo-haploid genome allowing stable mutants with desirable properties to be readily isolated. It is becoming increasingly evident that the manipulation of glycosylation pathways to produce secreted glycoprotein therapeutics with glycans appropriate for optimal half-life, cellular targeting and functional activity, is very important. This editorial will discuss CHO glycosylation mutants that are currently available, and the potential for glycosylation engineering to produce optimal biopharmaceuticals in the future. CHO cell mutants with altered glycosylation were initially isolated by selection for resistance to the cytotoxicity of plant lectins [1]. Cells selected for resistance to one lectin, were often resistant to others with related glycan binding properties, and also hypersensitive to lectins recognizing sugars that became newly terminal due to the nature of the glycosylation defect. By comparing resistance to a panel of plant lectins, lectin-resistant mutants could be grouped into lectin resistance phenotypes. In addition, somatic cell hybridization was used to define genetic complementation groups. Once genes encoding glycosylation activities were cloned, mutations giving rise to each complementation group were identified and numerous allelic series defined. There are now a large number of CHO glycosylation mutants with known genetic and biochemical defects that may be used to engineer glycoproteins in order to optimize their properties. These include mutants that generate glycoproteins with modified N-glycans and/or O-glycans [2], glycosaminoglycans [3] or glycophosphotidylinositol-linked glycans [4]. However, for these mutants to be useful in the industrial level production of glycoprotein therapeutics, a specific glycosylation mutant must be employed from the very beginning of engineering a cell line for high productivity. While it is often stated that existing CHO mutant lines are not high producers, this may Pamela Stanley Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, USA pamela.stanley@einstein.yu. edu “. manipulation of glycosylation to enhance the properties of glycoproteins can be performed at any stage of the development of a production cell line using CRISPR/Cas9 technology. ” SPECIAL FOCUS y An ‘omics approach to Chinese hamster ovary-based pharmaceutical bioprocessing
Estimating the Indirect Gaming Contribution of Bingo Rooms

Anthony F. Lucas* William T. Dunn Anria Kharitonova Using data from two repeater market hotel casinos, the relationship between bingo and slot business volumes is explored. Contrary to conjecture supplied by industry executives, the results fail to demonstrate a statistically significant relationship between daily bingo headcount and coin-in. This result was found in three different analyses, including one· attempt to estimate the impact of bingo headcount on low-denomination coin-in. This study advances the literature by challenging the assumption that bingo rooms produce substantial indirect slot profits. Given the minimal direct contribution to property cash flows, if any, the results suggest that bingo rooms are not always the highest and best use of valuable casino floor space.
Operads and Jet modules

Let A be an algebra over an operad in a cocomplete closed symmetric monoidal category. We study the category of A-modules. We define certain symmetric product functors of such modules generalizing the tensor product of modules over commutative algebras, which we use to define the notion of a jet module. This in turn generalizes the notion of a jet module over a module over a classical commutative algebra. We are able to define Atiyah classes (i.e., obstructions to the existence of connections) in this generalized context. We use certain model structures on the category of A-modules to study the properties of these Atiyah classes. The purpose of the paper is not to present any really deep theorem. It is more about the right concepts when dealing with modules over an algebra that is defined over an arbitrary operad, i.e., the aim is to show how to generalize various classical constructions, including modules of jets, the Atiyah class and the curvature, to the operadic context. For convenience of the reader and for the purpose of defining the notations, the basic definitions of the theory of operads and model categories are included.
Short and Long Run Asymmetric Effects of Monetary and Fiscal Policy Uncertainty on Economic Activity in the U.S

This paper extends the ongoing literature on the macroeconomic effects of monetary and fiscal policy uncertainty. It examined the asymmetric effects of monetary and fiscal policy uncertainty on economic activity in the short and long run using U.S. monthly data from 1985M1 to 2017M2. The industrial production index is used as a measure of economic activity while the Baker et al (2016) news based monetary and fiscal policy uncertainty were used as measures of uncertainty. To analyse asymmetry, the paper employed the nonlinear autoregressive distributed lag (NARDL) model which allows one not only to capture the effects of positive and negative uncertainty but to do so in both short and long run. Hence this paper provides new evidence of possible existence of a nonlinear and asymmetric relationship between policy uncertainty and economic activity in the short and long run. The results show that monetary and fiscal policy uncertainty share long run relationship with economic activity. Further, the effect of monetary and fiscal policy uncertainties in the long run is asymmetric. Asymmetric effect in the short run was supported only for monetary policy uncertainty. These findings have important practical and policy implications.
Inhibitory Effect of Lactobacillus plantarum CQPC02 Isolated from Chinese Sichuan Pickles (Paocai) on Constipation in Mice

Sichuan pickles (Paocai) are a traditional Chinese fermented vegetable food that is rich in beneficial microorganisms. In this study, the inhibition of constipation by Lactobacillus plantarum CQPC02 (LP-CQPC02) isolated from Sichuan Paocai was studied by establishing a constipation model of mice using activated carbon. The constipation inhibition effect of LP-CQPC02 was determined by observing the defecation of mice, rate of active carbon propulsion, pathological section observation, serum index, and small intestinal mRNA expression. The results showed that LP-CQPC02 inhibited the decrease in body weight caused by constipation in mice. At the same time, LP-CQPC02 also increased the propulsion rate of activated carbon in the small intestine and shortened the time of discharge for the first black stool. LP-CQPC02 increased gastrin (Gas), motilin (MTL), endothelin (ET), and acetylcholinesterase (AChE) in constipated mice, and it also decreased the level of somatostatin (SS). qPCR results showed that LP-CQPC02 upregulated the expression of c-Kit, stem cell factor (SCF), and glial cell-derived neurotrophic factor (GDNF) and downregulated the expression of transient receptor potential cation channel subfamily V member 1 (TRPV1) and inducible nitric oxide synthase (iNOS) in mice with constipation, and a stronger effect was observed with a high concentration of LP-CQPC02. The experimental results showed that LP-CQPC02 has a stronger constipation inhibitory effect than the commonly used commercial Lactobacillus delbrueckii subsp. bulgaricus (LB), and the inhibitory effect of LP-CQPC02 on constipation increases with increasing concentration of LP-CQPC02. Therefore, LP-CQPC02 is a high-quality microbial resource with a good constipation inhibition effect and probiotic potential.
Subsurface Fluid Flow and Imaging: With Applications for Hydrology, Reservoir Engineering, and Geophysics

In the study of the Earth one encounters a wide array of physical processes. Examples which quickly come to mind are transient pressure variations associated with fluid flow, the propagation of elastic and electromagnetic waves, inelastic deformation, reactive chemical transport, and multiphase flow. This diversity rivals that of any other discipline. On the surface, these phenomena may seem unrelated, and it is difficult to envision techniques, other than numerical modeling, which could prove useful across such a wide range of processes. Our understanding of the complex systems that comprise our planet is hampered by a difficulty characteristic of the Earth Sciences; our observations are, for the most part, remote and indirect. That is, measurements are typically gathered at the Earth’s surface or from a relatively small number of boreholes penetrating the depths. Thus, the details of the physical system are shielded from view by the Earth itself. To be sure, great advances have been made in geophysical imaging and in a sense it is possible to ‘see’ within the Earth. However, as compared to a physics laboratory, a completely controlled field experiment is the exception rather than the rule in the geosciences. This necessitates tackling what is known as the inverse problem, the complement to the modeling of a natural system. In the inverse problem, remote observations are used to infer properties, usually model parameters, describing the system. For example, seismic amplitude and arrival time changes gathered in timelapse monitoring are used to infer saturation and pressure changes in a reservoir due to fluid production. Increasingly, other fields such as medicine and non-destructive testing are adopting imaging and inversion for non-invasive evaluation. In large measure this book is concerned with modeling techniques developed with the inverse problems in mind. To this end we shall be concerned with methods that place a premium on efficiency, flexibility, simplicity, and physical intuition. For example, finite-difference techniques, extremely versatile but computationally
SEALDB: An Efficient LSM-tree Based KV Store on SMR Drives with Sets and Dynamic Bands

Key-value (KV) stores play an increasingly critical role in supporting diverse large-scale applications in modern data centers hosting terabytes of KV items which even might reside on a single server due to virtualization purposes. The combination of the ever-growing volume of KV items and storage/application consolidation is driving a trend of high storage density for KV stores. Shingled Magnetic Recording (SMR) represents a promising technology for increasing disk capacity, which however comes with the increased complexity of handling random writes. To take the best advantages of SMR drives, applications are expected to work in an SMR-friendly way. In this work, we present SEALDB, a Log-Structured Merge tree (LSM-tree) based key-value store that is specifically optimized for SMR drives via avoiding random writes and the corresponding write amplification on SMR drives. First, for LSM-trees, SEALDB collects and groups participating data of each compaction into sets. Using a set as the basic unit for compactions, SEALDB improves compaction efficiency by reducing random I/Os. Second, SEALDB creates variable sized bands on original HM-SMR drives, named dynamic bands. Dynamic bands store sets in an SMR-friendly way to eliminate the auxiliary write amplification from SMR drives. Third, SEALDB employs two light-weight garbage collection (GC) policies to further improve the space efficiency. We demonstrate the advantages of SEALDB via extensive experiments with various workloads. Overall, SEALDB delivers impressive performance compared with LevelDB, e.g., $3.42\times$3.42×/$2.65\times$2.65× faster for random writes (without or with GCs), and $3.96\times$3.96× faster for sequential reads.
Zeitschrift für anorganische und allgemeine Chemie

S. 1 2 9 2 0 . Glemser, Göttingen J . Goubeau, Stuttgart Ν. N . Greenwood, Leeds Η. Grunze, Berl in-Adlershof V. Gutmann, W i e n P. Hagenmuller , Bordeaux H . Haraldsen, Oslo -Bl indern S. Herzog, Freiberg/Sachsen K . Issleib, Hal le /S. B. Jezowska-Trzebiatowska, Wroc law R. Juza, K i e l W . Rüdorff, Tübingen H . Schäfer, Münster i . W . M . Schmidt, Würzburg F. Seei, Saarbrücken A. S imon, Stuttgart V . I . Sp i tz in , Moskau K . H . Thiele , Merseburg E. U h l i g , Jena U . Wannagat , Braunschweig W r. W i e k e r ; Berl in-Adlershof