Miracle-dz/UniFAR-FTUs huggingface dataset:
All-solid-state asymmetric supercapacitor based on reduced graphene oxide/carbon nanotube and carbon fiber paper/polypyrrole electrodes

Sandwich-like reduced graphene oxide/carboxylated multi-walled carbon nanotube (RGO/cMWCNT) hybrid film and the carbon fiber paper-supported polypyrrole (CFP/PPy) composite film were prepared by a vacuum-infiltration process and an electrochemical deposition method, respectively. Furthermore, a novel all-solid-state asymmetric supercapacitor (ASC) was fabricated using RGO/cMWCNT as the negative electrode and CFP/PPy as the positive electrode, separated with potassium polyacrylate/KCl gel electrolyte. Due to the unique structure, stable potential window and good capacitive performance of the two electrodes, the as-fabricated ASC can be cycled reversibly at a cell voltage of 1.6 V and displays outstanding performances with an energy density of 28.6 W h kg−1 and a power density of 15.1 kW kg−1. Additionally, our ASC device also presents a superior long cycle life with 93% capacitance retention after 2000 cycles.
On the Dutch Registry of catheter ablation of atrial fibrillation.

We would like to submit a reaction to the paper on the Dutch Registry on pulmonary vein isolation. The authors present a nice overview of the outcome of pulmonary vein isolation in their country in the years 2012–2017, however with a rather weak follow-up. The strength of the paper lies in the numbers. That an almost forgotten technique was used to compose one group does not matter: pulsed radiofrequency (RF) or Pulmonary Vein Ablation Catheter (PVAC) (which was only submitted to a small randomized trial, not showing a real benefit vs. conventional RF) seemed almost as good as conventional RF. Therefore, it has finally merited a place in clinical electrophysiology. The article focuses on complications (which was the title, and the registry probably was designed to show these data), and not on efficacy of the various techniques, which is more difficult. However, this is a missed opportunity. The European Registry showed already the excess of complications in women. A first question is whether the design of the paper does not underestimate the real number of the complications. The overall number seems to be very acceptable. Follow-up was incomplete, and mortality was lacking in a few centres. The only drawback of cryoballoon ablation was the presence of phrenic nerve damage. It is a pity that no effort was performed to see whether this complication remained present at 3 months. If we count the other complications (except mortality)—it becomes 160/5976 (2.67%) for RF vs. 140/5108 (2.74%) for cryo. The number for phased RF is ridiculously low. Furthermore, complications as pulmonary vein stenosis were not specifically mentioned. The second point is the missed chance to comment on efficacy. The data are in the report, but not mentioned. A repeat ablation is a good surrogate for efficacy, and also for comparative efficacy in the three groups. It is not remarkable that conventional RF and PVAC result in 20, respectively 26% re-ablation vs. 13% for the cryoballoon. This could have been predicted from published randomized trials of cryo vs. RF, and from extrapolating various recent observational studies. This becomes even more striking when one considers that 30% of the RF group already had a re-ablation as entry in the Registry. This might be a bias, as the number of persistent patients was higher in the conventional RF group. Some data have now been published on the efficacy of cryoballoon ablation on persistent atrial fibrillation as well. Furthermore, the number of persistent patients in the PVAC group was similar to the proportion in the cryoballoon group, whereas the number of repeat procedures in the cryoballoon group was only half that of PVAC. On might ask therefore whether PVAC still has a place, and this should have been one of the conclusions. Furthermore, if a patient is selected for conventional RF, he should be informed that his chances for a repeat procedure are probably higher than when a cryoballoon procedure is intended. More recent improvement of both techniques probably did not change the outcome of the cards. Conflict of interest: none declared.
Prenatal maternal transdiagnostic, RDoC-informed predictors of newborn neurobehavior: Differences by sex

Abstract We examined whether Research Domain Criteria (RDoC)-informed measures of prenatal stress predicted newborn neurobehavior and whether these effects differed by newborn sex. Multilevel, prenatal markers of prenatal stress were obtained from 162 pregnant women. Markers of the Negative Valence System included physiological functioning (respiratory sinus arrhythmia [RSA] and electrodermal [EDA] reactivity to a speech task, hair cortisol), self-reported stress (state anxiety, pregnancy-specific anxiety, daily stress, childhood trauma, economic hardship, and family resources), and interviewer-rated stress (episodic stress, chronic stress). Markers of the Arousal/Regulatory System included physiological functioning (baseline RSA, RSA, and EDA responses to infant cries) and self-reported affect intensity, urgency, emotion regulation strategies, and dispositional mindfulness. Newborns’ arousal and attention were assessed via the Neonatal Intensive Care Unit (NICU) Network Neurobehavioral Scale. Path analyses showed that high maternal episodic and daily stress, low economic hardship, few emotion regulation strategies, and high baseline RSA predicted female newborns’ low attention; maternal mindfulness predicted female newborns’ high arousal. As for male newborns, high episodic stress predicted low arousal, and high pregnancy-specific anxiety predicted high attention. Findings suggest that RDoC-informed markers of prenatal stress could aid detection of variance in newborn neurobehavioral outcomes within hours after birth. Implications for intergenerational transmission of risk for psychopathology are discussed.
Self-compassion as predictor of daily physical symptoms and chronic illness across older adulthood

This study examined whether self-compassion could benefit daily physical symptoms and chronic illness in early and advanced old age. The hypotheses were evaluated in a 4-year longitudinal study of 264 older adults. Results showed that self-compassion predicted lower levels of daily physical symptoms across the study period in advanced, but not early, old age (T-ratio = −1.93, p = 0.05). In addition, self-compassion was associated with fewer increases in chronic illness in advanced, but not early, old age (T-ratio = − 2.45, p < 0.02). The results of this study suggest that self-compassion may be particularly adaptive towards the end of life.
Metabolic engineering of astaxanthin‐rich maize and its use in the production of biofortified eggs

Summary Production of the high‐value carotenoid astaxanthin, which is widely used in food and feed due to its strong antioxidant activity and colour, is less efficient in cereals than in model plants. Here, we report a new strategy for expressing β‐carotene ketolase and hydroxylase genes from algae, yeasts and flowering plants in the whole seed using a seed‐specific bidirectional promoter. Engineered maize events were backcrossed to inbred maize lines with yellow endosperm to generate progenies that accumulate astaxanthin from 47.76 to 111.82 mg/kg DW in seeds, and the maximum level is approximately sixfold higher than those in previous reports (16.2–16.8 mg/kg DW) in cereals. A feeding trial with laying hens indicated that they could take up astaxanthin from the maize and accumulate it in egg yolks (12.10–14.15 mg/kg) without affecting egg production and quality, as observed using astaxanthin from Haematococcus pluvialis. Storage stability evaluation analysis showed that the optimal conditions for long‐term storage of astaxanthin‐rich maize are at 4 °C in the dark. This study shows that co‐expressing of functional genes driven by seed‐specific bidirectional promoter could dramatically boost astaxanthin biosynthesis in every parts of kernel including embryo, aleurone layer and starch endosperm other than previous reports in the starch endosperm only. And the staple crop maize could serve as a cost‐effective plant factory for reliably producing astaxanthin.
Mechano-biology of cell division in plant growth.

Cell division in plants is particularly important as cells can not rearrange. It thus determines the arrangement of cells (topology) and their size and shape (geometry). Cell division reduces mechanical stress locally by producing smaller cells and alters mechanical properties by reinforcing the mechanical wall network, both of which can alter overall tissue morphology. Division orientation is often regarded as following geometric rules, however, recent work suggests that divisions align with the direction of maximal tensile stress. Mechanical stress has already been shown to feed into many processes of development including those that alter mechanical properties. Such an alignment may enable cell division to selectively reinforce the cell wall network in the direction of maximal tensile stress. Thus there exists potential feedback between cell division, mechanical stress and growth. Improving our understanding of this topic will help to shed light on the debated role of cell division in organ scale growth.
NiCl2(1,2-Diiminophosphorane) complexes: a new family of readily accessible and tuneable catalysts for oligomerisation of ethylene

1,2-Diiminophosphoranes 1–4 featuring either ethane, benzene, cyclohexane or 1,2-diphenylethane carbon backbones act as tightly bonded 1,4-chelating ligands towards NiCl2, affording the corresponding paramagnetic complexes 5–8 in high yield. X-Ray diffraction studies performed on compounds 5 and 6 revealed that the conformation of the five-membered metallacycle depends on the rigidity of the carbon backbone. For both complexes, the coordination sphere of the Ni atom is a distorted tetrahedron with bond lengths and angles around nickel similar to those observed for related Ni(II)(α-diimine) complexes. Complexes 5–8 are active for ethylene oligomerisation under mild reaction conditions (0°C, 1.1 bar) upon activation by alkylaluminum derivatives (Et2AlCl or MAO). The nature of the carbon backbone of the 1,2-diiminophosphorane ligands has a profound impact on the selectivity of the catalytic systems. The selectivity for trimers and higher oligomers varies from 10% (pre-catalyst 8) to 81% (pre-catalyst 5). Effects of varying ethylene pressure, temperature and aluminium co-catalyst/nickel ratios with pre-catalyst 6 are reported. Tailoring the reaction parameters has a modest effect on the oligomer distribution but allows quite high catalytic activities to be achieved with turnover frequencies up to 135×103 h−1.
Historical view and current status of plasma displays

After the principle of DC and AC plasma displays are explained, the brief history of research and development of color plasma displays are described. The reasons why the surface-discharge AC color plasma displays has survived is also described concerning the specific performance. The next generation of color plasma displays are discussed for the coming era of color plasma display TV.
Rheumatoid arthritis related interstitial lung disease

ABSTRACT Introduction Interstitial lung disease (ILD) represents a frequent extra-articular manifestation of rheumatoid arthritis (RA) deeply impacting both quality of life and overall prognosis. Areas covered: A literature search was performed including PubMed, Embase, Scopus, and Web of Science. Many retrospective studies investigated the possible risk factors for RA-related ILD (RA-ILD), aiming to identify patients at risk. Among them, males, smokers, positivity of anti-citrullinated peptide antibodies have been associated with RA-ILD, such as some genetic haplotypes. Usual interstitial pneumonia is the histologic and radiologic pattern most frequently observed, followed by nonspecific interstitial pneumonia. Since lung involvement can represent the RA onset, an early differential diagnosis with idiopathic interstitial pneumonia can be difficult or sometimes impossible. High-resolution computed tomography represents the gold standard for ILD diagnosis, while multidisciplinary discussion should be required to assess disease staging, severity and progression. Expert opinion: Management of RA-ILD patients is challenging due to the lack of evidence-based data regarding both assessment and treatment. Moreover, the high variability of clinical presentation and evolution makes it diﬃcult to establish the correct therapeutic strategy. Currently, multidisciplinary approach, including at least rheumatologists, pulmonologists, and radiologists, is desirable to define therapy and follow-up strategies.
Blood Pressure Levels in Young Adulthood and Midlife Stroke Incidence in a Diverse Cohort

Supplemental Digital Content is available in the text. We examined the longitudinal association between blood pressure (BP) and stroke incidence in young and middle-aged adults. BP measured during 9 examinations of the CARDIA study (Coronary Artery Risk Development in Young Adults) from 1985-1986 to 2015-2016 was used to classify participants (n=5079) according to the 2017 Hypertension Clinical Practice Guidelines. We used the highest BP obtained through the third examination (1990–1991) to define baseline BP categories; time-dependent categories (accounting for change in BP over time) were determined incorporating follow-up measurements. BP groups at ages 30 and 40 years were also defined. Stroke events were adjudicated until 2018. Mean age at baseline was 29.8 years. Stroke occurred in 100 participants. Stroke incidence (per 100 000 person-years) was higher (P<0.001) in Black (120 [95% CI, 95–149]) versus White (29 [95% CI, 18–46]) participants. After adjustment with Cox models for sociodemographic and cardiovascular risk factors, stage 2 hypertension was associated with a higher risk of stroke at baseline (hazard ratio, 3.72 [95% CI, 2.12–6.54]), as a time-dependent variable (hazard ratio, 5.84 [95% CI, 3.43–9.95]), at age 30 (hazard ratio, 4.14 [95% CI, 2.19–7.82]) and at age 40 (hazard ratio, 5.59 [95% CI, 3.35–9.31]), compared with normal BP. Elevated BP and stage 1 hypertension showed more modest increases in risk. As a continuous variable, systolic BP ≥90 mm Hg at age 40 was directly associated with stroke risk. These findings call for primordial prevention strategies to reduce population BP levels among young and middle-aged adults, particularly in Black young adults given ≈4-fold higher stroke incidence, including within values traditionally considered to be normal.
Accounting for genetic architecture for body weight improves accuracy of predicting breeding values in a commercial line of broilers

Abstract BLUP (best linear unbiased prediction) is the standard for predicting breeding values, where different assumptions can be made on variance–covariance structure, which may influence predictive ability. Herein, we compare accuracy of prediction of four derived‐BLUP models: (a) a pedigree relationship matrix (PBLUP), (b) a genomic relationship matrix (GBLUP), (c) a weighted genomic relationship matrix (WGBLUP) and (d) a relationship matrix based on genomic features that consisted of only a subset of SNP selected on a priori information (GFBLUP). We phenotyped a commercial population of broilers for body weight (BW) in five successive weeks and genotyped them using a 50k SNP array. We compared predictive ability of univariate models using conservative cross‐validation method, where each full‐sib group was divided into two folds. Results from cross‐validation showed, with WGBLUP model, a gain in accuracy from 2% to 7% compared with GBLUP model. Splitting the additive genetic matrix into two matrices, based on significance level of SNP (Gf: estimated with only set of SNP selected on significance level, Gr: estimated with the remaining SNP), led to a gain in accuracy from 1% to 70%, depending on the proportion of SNP used to define Gf. Thus, information from GWAS in models improves predictive ability of breeding values for BW in broilers. Increasing the power of detection of SNP effects, by acquiring more data or improving methods for GWAS, will help improve predictive ability.
Female breast cancer treatment and survival in South Australia: Results from linked health data

Abstract Objective We investigated treatment and survival by clinical and sociodemographic characteristics for service evaluation using linked data. Method Data on invasive female breast cancers (n = 13,494) from the South Australian Cancer Registry (2000–2014 diagnoses) were linked to hospital inpatient, radiotherapy and universal health insurance data. Treatments ≤12 months from diagnosis and survival were analysed, using adjusted odds ratios (aORs) from logistic regression, and adjusted sub‐hazard ratios (aSHRs) from competing risk regression. Results and conclusion Five‐year disease‐specific survival increased to 91% for 2010–2014. Most women had breast surgery (90%), systemic therapy (72%) and radiotherapy (60%). Less treatment applied for ages 80+ vs <50 years (aOR 0.10, 95% CI 0.05–0.20) and TNM stage IV vs stage I (aOR 0.13, 95% CI 0.08–0.22). Surgical treatment increased during the study period and strongly predicted higher survival. Compared with no surgery, aSHRs were 0.31 (95% CI 0.26–0.36) for women having breast‐conserving surgery, 0.49 (95% CI 0.41–0.57) for mastectomy and 0.42 (95% CI 0.33–0.52) when both surgery types were received. Patients aged 80+ years had lower survival and less treatment. More trial evidence is needed to optimise trade‐offs between benefits and harms in these older women. Survival differences were not found by residential remoteness and were marginal by socioeconomic status.
Hierarchical design of nanostructured materials based on polyoxometalates

Abstract The construction of nanostructured materials with advanced functions by the self-organization of molecular building blocks is one of the key topics in modern materials chemistry. This review describes our concept of the hierarchical design of polyoxometalate (POM)-based compounds with nanosized spaces: (1) syntheses of building blocks (POMs and counter cations), (2) directing the self-organization of building blocks to form crystalline materials with nanosized spaces, and (3) kinetic control of the self-organization process to introduce nanosized space into the dense nonporous crystal, with emphasis on (2). Our recent results on the construction of nanosized spaces within the POM-based compounds with controlled size, volume, shape, and affinity, and their functions are presented.
Dielectric Properties of Twisted Nematic Liquid Crystal Displays Fabricated by Doping Ag-Pd Metal Nanoparticles Having A Long Term Stability

ABSTRACT TN-LCDs particularly doped with the metal nanoparticles of Ag-Pd composite, which are protected by chemical covering with nematic liquid crystal, 5CB (K-15, Merck) as a ligand, are shown to exhibit a long term stability in the electro-optical (EO) effect featured by a frequency modulation with short response times of ms or sub-ms order. This device is called FM-LCD. The unique electro–optical characteristics of the FM-LCD were clarified in terms of the Maxwell-Wagner effect of a heterogeneous dielectrics, where the analysis is done using an equivalent circuit model rather than the conventional potential theory; and we derived the formulae of the dielectric strength and the dielectric relaxation time. The former is used to explain the FM-LCD effect and also to evaluate the effective electrical conductivity of the metal nanoparticle that will be 4.4 × 104 S/m, which is about 1 × 10−3 times smaller than that of metal Ag; and the latter is expressed to demonstrate that the relaxation time decreases with increasing the concentration of metal nanoparticle for the first time.
Polymorphism, expression and structure analysis of key genes in the ovarian steroidogenesis pathway in sheep (Ovis aries)

Abstract Background Litter size is an important factor that significantly affects the development of the sheep industry. Our previous TMT proteomics analysis found that three key proteins in the ovarian steroidogenesis pathway, STAR, HSD3B1, and CYP11A1, may affect the litter size trait of Small Tail Han sheep. Objective The purpose of this study was to better understand the relationship between polymorphisms of these three genes and litter size. Material and Method Sequenom MassARRAY detected genetic variance of the three genes in 768 sheep. Real‐time qPCR of the three genes was used to compare their expression in monotocous and polytocous sheep in relevant tissues. Finally, bioinformatics analysis predicted the protein sequences of the different SNP variants. Result Association analysis showed that there was a significant difference in litter size among the genotypes at two loci of the CYP11A1 gene (p < 0.05), but no significant difference was observed in litter size among all genotypes at all loci of the STAR and HSD3B1 genes (p > 0.05). However, STAR expression was significantly different in polytocous and monotocous sheep in the pituitary (p < 0.01). Tissue‐specific expression in the ovary was observed for HSD3B1 (p < 0.05), but its expression was not different between polytocous and monotocous sheep. Bioinformatics analysis showed that the g.33217408C > T mutation of CYP11A1 resulted in major changes to the secondary and tertiary structures. In contrast, gene polymorphisms in STAR and HSD3B1 had minimal impacts on their protein structures. Discussion This may explain why the CYP11A1 variant impacted litter size while the others did not. The single nucleotide polymorphism of the CYP11A1 gene would serve as a good molecular marker when breeding to increase litter size in sheep. Our study provides a basis for further revealing the function of the ovarian steroidogenesis pathway in sheep reproduction and sheep breeding.
Fabrication and in vitro evaluation of thermally cross-linked gelatin nanofibers for drug delivery applications

Abstract In this study, four different nanofibers consisting of gelatin (Gel), doxorubicin (DOX) with gel (DOX@Gel), a composite of gel with poly(ethylene glycol) (PEGylated-gel), and DOX@PEGylated-gel were fabricated. Subsequently, the nanofibers were thermally cross-linked in order to offer a stable and biocompatible alternative for the biological applications of nanofibers such as drug delivery and tissue engineering. Nanofibers were characterized by scanning electron microscopy, Fourier Transform-Infrared Spectroscopy (FT-IR), and confocal microscopy. The formation of smooth, continuous, and uniform nanofibers was observed and the addition of PEG resulted in an increase whereas the incorporation of DOX into nanofibers had no significant change in the diameter of nanofibers. Crosslinking also enlarged the diameter of all nanofibers and the most dramatic increase was observed 53% by DOX@PEGylated-gel. Afterward, the biological performance of the nanofibers was investigated by drug release profile, cytotoxicity on A549 cell line as well as antimicrobial activity with E. coli and S. aureus. The results indicate an enhanced drug release profile, moderate antimicrobial activity, and reasonable cytotoxic efficiency for thermally cross-linked nanofibers compared to uncross-linked nanofibers. Graphical Abstract