Miracle-dz/UniFAR-FTUs huggingface dataset:
Joint British Diabetes Societies for Inpatient Care (JBDS‐IP) Clinical Guideline Inpatient care of the frail older adult with diabetes: an Executive Summary

We present an Executive Summary of a guideline produced by a Joint British Diabetes Societies for Inpatient Care Writing Group for managing frail older inpatients with diabetes. This represents a multidisciplinary stakeholder consensus document providing more than 100 recommendations in eight areas: functional assessment and detection of frailty; preventative care: assessing risk factors and avoiding hospital admissions; general inpatient management principles; managing therapy choices for the frail older inpatient with diabetes; managing associated comorbidities and concerns; pre‐operative assessment and care; discharge planning and principles of follow‐up; and end of life care. The document is intended to guide effective clinical decision‐making in an inpatient setting and is supported by four appendices: Appendix 1, STOPPFRAIL criteria; Appendix 2, Acute care toolkit 3—Royal College of Physicians; Appendix 3, a description of physical performance and frailty measures for routine NHS application; and Appendix 4, Inpatient Frailty Care Pathway—template. This document is expected to enhance clinical outcomes and overall health status for this vulnerable inpatient population of older people with diabetes. The full version of the guideline, including the appendices, can be found at https://abcd.care/sites/abcd.care/files/resources/Inpatient_Care_of_the_Frail_Older_Adult. pdf
Identification automatique des sources des notices zoologiques du Speculum naturale de Vincent de Beauvais

— With his encyclopaedia Speculum maius, the xiiith century Dominican Vincent de Beauvais tries to form a general knowledge synthesis. To do so, he gathers information coming from a multitude of different sources, christian as well as pagan, from classical Antiquity as well as from Middles Ages. Most of his work’s notices contain an explicit mention of the sources from which they were drawn, unlike many other medieval encyclopaedias. This feature allows using the Speculum maius as an experimentation dataset, and applying supervised learning and text mining techniques in order to automatically link the encyclopaedic notices to their sources. In this paper, we undertake such an exercise for the zoological books of the encyclopaedia, and we analyze the contributions, limitations and perspectives of the results we have obtained, having in mind to apply our methods to encyclopaedias which do not mention their sources in the future.
The use of GV-971 induces liver injury in an Alzheimer's disease patient

A 57-year old woman with Alzheimer’s disease developed liver injury 4 days after starting GV-971 therapy. This woman had no history of drug allergy before her AD diagnosis. After started her GV-971 medication (150 mg bid) while taking donepezil and memantine hydrochloride, she presented with jaundice of the skin and sclera, loss of appetite and fatigue. Laboratory examination suggested that liver function was abnormal with serum levels of alanine transaminase (ALT) (737 U/L), aspartate transaminase (1006 U/L). And Magnetic Resonance Imaging (MRI) showed the interstitial edema of the portal vein and the thickened gallbladder wall, which suggested the possibility of active liver disease or liver injury. Our report showed that GV-971 may lead to liver injury and we suggest that clinicians should monitor liver functions when using GV-971 in AD patients.
Exercise effects on muscle glycogen concentration in beef cattle

Low ultimate-pH of beef is desirable because it increases shelf life and has beneficial effects on colour and tenderness. Industry recommendations are that beef animals are not exercised strenuously prior to trucking, as this may trigger depletion of muscle glycogen and lead to higher beef pH. In 2 experiments, 400-500 kg 18-month-old steers were exercised at a range of intensities up to 5 km distance at 8 km/hr. Biopsy samples from the longissimus dorsi muscle were taken and glycogen concentration measured. Although plasma lactate levels were elevated by exercise there was no significant depletion in muscle glycogen concentration (average 17.7 mg/g tissue). Depletion may have occurred had animals been heavier and fatter, or if the exercise regime had been more severe. Alternatively, it may be that at the level of exercise imposed (which was severe by farm-practice standards), animals also needed to be emotionally s tressed in order to precipitate a depletion of glycogen, through a combination of muscle contractile and adrenergic reactions.
A Wonder Drug in the Arsenal against COVID - 19: Medication Evidence from Ivermectin

Ivermectin, an FDA approved broad-spectrum anti-parasitic agent has been recently reported to show an inhibitory activity against SARS-CoV-2 in an in-vitro study. This antiviral response has rendered it as a potential drug to be repurposed for COVID-19. Previously, ivermectin had showed inhibitory activity against RNA viruses in-vitro and DNA viruses in-vitro and in-vivo respectively. Much of its characterization has been related to SARS-CoV wherein viral proteins interacting with IMPα/β1 (Importins) were proposed to enhance the viral infectivity. These documentations serve as a ray of hope for considering ivermectin in treating COVID-19 due to its suggested nuclear transport inhibitory mechanism. Importantly, these recent findings warrant detailed investigations for understanding its benefit in terms of efficacy and safety in COVID-19 patients. This review article throws light on the current consensus in this regard. Review Article Kumar et al.; JAMMR, 32(10): 30-37, 2020; Article no.JAMMR. 58177 31
Modelling the Present Global Terrestrial Climatic Response Due to a Chicxulub-Type Asteroid Impact

A Chicxulub-like asteroid event occurs, on average, approximately every ~27 to 200 million years. Therefore, such an event could happen presently. Here, we simulate the climatic anomalies it may cause with respect to the current conditions, assuming the same target geology of carbonates and evaporates and a 1 Gt release of sulphate gases. We used a thermodynamic model, including water vapor, cloudiness (by greenhouse and albedo effects), and cryosphere feedback to calculate aerosol cooling. We found that it took nearly 4.5 years for solar radiation to recover its preimpact value—during the first year practically no solar radiation reached the surface. Recovery of the temperature took more than 45 years. The lowest temperatures occurred between 1.5 and 5 years after the impact, being the coldest at −14 °C below the preimpact temperature. July surface temperature anomalies occurred 1.5 years after the impact, becoming one of the largest, compared to preimpact temperatures. Most continents showed temperature anomalies of −45 °C. The least cold places were the polar regions with temperature anomalies between approximately −5 and 0 °C. As for the most remarkable climatic effect, we found that, for ~6 years, the ice extended over almost all the ocean surface and, after ~25 years, it covered nearly half of the surface, remaining so for beyond 45 years. The continental ice remained without reduction beyond 45 years. Sixty years after the impact, the surface oceanic and continental fractions covered by ice were 0.52 and 0.98, respectively. We also modeled the effect of smaller quantities of sulfur released after asteroid impacts, concluding that an instantaneous, large climatic perturbation attributed to a loading range may lead to a semi-permanent shift in the climate system.
Carnelian: alignment-free functional binning and abundance estimation of metagenomic reads

Accurate assignment of metagenomic reads to their functional roles is an important first step towards gaining insights into the relationship between the human microbiomeincluding the collective genesand disease. Existing approaches focus on binning sequencing reads into known taxonomic classes or by genes, often failing to produce results that generalize across different cohorts with the same disease. We present Carnelian, a highly precise and accurate pipeline for alignment-free functional binning and abundance estimation, which leverages the recent idea of even-coverage, low-density locality sensitive hashing. When coupled with one-against-all classifiers, reads can be binned by molecular function encoded in their gene content with higher precision and accuracy. Carnelians minutes-per-metagenome processing speed enables analysis of large-scale disease or environmental datasets to reveal disease- and environment-specific changes in microbial functionality previously poorly understood. Our pipeline newly reveals a functional dysbiosis in patient gut microbiomes, not found in earlier metagenomic studies, and identifies a distinct shift from matched healthy individuals in Type-2 Diabetes (T2D) and early-stage Parkinson’s Disease (PD). We remarkably identify a set of functional markers that can differentiate between patients and healthy individuals consistently across both the datasets with high specificity.
Effect of Implementing Advanced Cardiovascular Life Support (ACLS) Guidelines 2016 on Nurse’s Knowledge and Performance

Background and aim: Cardiac arrest occurs in case of cessation of effective heartbeat and blood circulation and it is one of the causes of sudden or unexpected death. Advanced cardiovascular life support (ACLS) considered, as a basic skill, is one of the most important inventions in hospital setting special intensive care units as well as a rapid and urgent intervention to prevent death or postpone it in a patient with cardiac arrest. This study aimed to assess effect of implementing advanced cardiovascular life support (ACLS) guidelines 2016 on nurse's knowledge and performance. Methods: A Quasi-Experimental study design with pre, intervention/posttest with a convenience sample included 300 nurses worked at 10 hospital settings. Data were collected by using three tools (1): Demographic Characteristics related to nurses, (2): Nurses knowledge toward ACLS pre/posttest, (3): Nurses performance an observation checklist toward ACLS according American Heart Association guidelines. Conclusions: The study confirms that significant association between the nursesi¯ knowledge and performance of ACLS in pre/posttest and their demographic characteristic. The educational program improves the knowledge and performance of the nursing staff regarding advanced life support. Recommendations: These findings indicate that it is imperative for nurses to receive regular, periodic in-service ACLS courses, updating AHA on the latest ACLS techniques, technologies and developments. In-service education program should make continuous training courses for the nurses about the new and up-to-date intervention related to knowledge & practice of American heart association ACLS.
A Review of Energy Harvesting Techniques for Low Power Wide Area Networks (LPWANs)

The emergence of Internet of Things (IoT) architectures and applications has been the driver for a rapid growth in wireless technologies for the Machine-to-Machine domain. In this context, a crucial role is being played by the so-called Low Power Wide Area Networks (LPWANs), a bunch of transmission technologies developed to satisfy three main system requirements: low cost, wide transmission range, and low power consumption. This last requirement is especially crucial as IoT infrastructures should operate for long periods on limited quantities of energy: to cope with this limitation, energy harvesting is being applied every day more frequently, and several different techniques are being tested for LPWAN systems. The aim of this survey paper is to provide a detailed overview of the the existing LPWAN systems relying on energy harvesting for their powering. In this context, the different LPWAN technologies and protocols will be discussed and, for each technology, the applied energy harvesting techniques will be described as well as the architecture of the power management units when present.
Infective Endocarditis Following TURP Procedures: A Case Report and Review of Literature

A common treatment and management of BPH is transurethral resection of the prostate (TURP) with at least 150,000 TURPs performed per year in the United States. Rates of bacteremia following TURP can be as low as 1% when antimicrobial prophylaxis is given. Patients can develop many common sequelae as a result of bacteremia secondary to TURP including bacteriuria and urinary tract infection; however, more serious complications such as endocarditis are quite rare (~1 in 4200 cases). Here we present a case of a 67 year-old-male with BPH who underwent two TURP procedures; both with appropriate antibiotic prophylaxis who was subsequently diagnosed with endocarditis
Resumen y análisis estadístico-matemático de las operaciones en el transporte urbano de la ciudad de Riobamba

DOI: https://doi.org/10.33262/concienciadigital.v3i3. 1321 The city of Riobamba is located relatively in the center of Ecuador, it is a city that is known as the city of the first fruits, for the activities of national relevance that occurred at the time, for its contribution to growth and development in different sectors , transport being a very important sector in the middle. Most of the inter-provincial and interprovincial Inter public road transport Cooperatives must pass through the city of Riobamba to reach the different cities of the coastal, mountain and eastern regions, due to their geographical location. This type of transport mobilizes a large number of people and transfers a good part of the merchandise that will be used for the production and commercialization of goods nationwide. A historic and emblematic city for the country, should not have problems in the issue of urban land transport internally and in the roads that connect with the surrounding cities, the quality of service provided by those involved in the transport sector, not only that allow to improve the income of the service providers, also allow to improve the income of other sectors that are related to transport.
The Risk Factors for Autoimmune Thyroid Disorder in Children with Chronic Spontaneous Urticaria

Kronik spontan urtikerin (KSU) etiyolojisi cogunlukla idiyopatik olmakla birlikte, hastalarin bir kisminda patogenezde otoimmunitenin rol oynadigini destekleyen calismalar vardir. KSU ve tiroid otoimmunitesi birlikteligi cogunlukla eriskinlerde arastirilmistir; ancak, cocuklarda veriler sinirlidir. Bu calismada, KSU tanisi almis cocuklarda anti tiroid peroksidaz (anti-TPO) antikor pozitifligi sikliginin saptanmasi ve otoimmun tiroid hastaligi icin risk faktorlerinin belirlenmesi amaclanmistir. Bu retrospektif tanimlayici calismada, iki farkli merkezde KSU tanisi ile izlenen 126 hasta degerlendirilmistir. Hastalarin demografik ve klinik ozellikleri, eslik eden bag doku hastaligi, otoimmun hastalik ve/veya allerjik hastaliklari ile her iki merkezde KSU hastalarinda rutin olarak yapilan tam kan sayimi, total IgE, antinukleer antikor (ANA), anti-TPO antikor, serbest tiroksin (sT4) ve tirotiropin (TSH) duzeylerini iceren laboratuvar sonuclari; deri prick testi ve otolog serum deri testi (OSDT) sonuclari dosya verilerinden elde edildi. Anti-TPO pozitifligi saptanan hastalarin tiroid ultrasanografisi bulgulari da kaydedildi. Calismamizda 5 (%4.0) hastada anti-TPO pozitifligi saptandi. Bu hastalarin 3’unde tiroid US’de parankim heterojenitesi mevcuttu. ANA pozitifligi hastalarin %10.2’sinde saptanmisti. Anti-TPO pozitifligi olan hastalarda ANA pozitifligi anlamli olarak yuksek idi (sirasiyla %60 ve %7.4, p=0.003). Dort hastada vitiligo tanisi mevcuttu ve bu hastalarda anti-TPO pozitifligi, vitiligo tanisi olmayan KSU tanili hastalara gore istatistiksel olarak anlamli olmamakla birlikte daha fazla saptandi (sirasiyla %20 ve %2.5, p=0.151) Kronik spontan urtikerli cocuklarda ANA pozitifligi otoimmun tiroid hastaligi icin risk faktoru olabilir. KSU’lu cocuklarda vitiligo ve otoimmun tiroid hastaligi iliskisi daha genis kohortlarda arastirilmalidir.
A Synthetic Pan-Aurora Kinase Inhibitor, 5-Methoxy-2-(2-methoxynaphthalen-1-yl)-4H-chromen-4-one, Triggers Reactive Oxygen Species-Mediated Apoptosis in HCT116 Colon Cancer Cells

Aurora kinases are Ser/Thr kinases that function as mitotic regulators. 5-Methoxy-2-(2-methoxynaphthalen-1-yl)-4H-chromen-4-one (DK1913) is a synthetic pan-Aurora kinase inhibitor. However, the mode of action of DK1913 concerning the induction of apoptosis is unclear. Here, we report that DK1913 triggered apoptosis, as revealed by flow cytometry and Annexin V staining. DK1913 enhanced the intracellular levels of reactive oxygen species (ROS) and stimulated the endoplasmic reticulum (ER) and genotoxic stress responses. We also found that DK1913 induced the loss of mitochondrial membrane potential, leading to the activation of caspase-9, caspase-7, and caspase-3. In addition, the antioxidant, butylated hydroxyanisole (BHA), abrogated DK1913-induced loss of mitochondrial membrane potential and activation of the caspase cascade. These findings demonstrate that pan-Aurora kinase inhibitor DK1913 triggers apoptosis through ROS-mediated ER and genotoxic stress responses.
Pretraživanje zdravstvenih informacija na internetu – implikacije za zdravstvenu anksioznost kod starijih osoba

Health information seeking on the Internet has become widespread. Since the elderly experience more health issues, they might become more frequent users of digital health content. But, since their computer skills are less advanced and since they are not used to the role of the „empowered patient“, researching their symptoms online might result in excessive anxiety. Research suggests that health information seeking might be a risk factor for pathological health anxiety, yet it may have a specific effect on the elderly. Studies on health information seeking in older adults are sparse and mostly conducted without a clear theoretical framework which complicates meaningful interpretation and integration of their findings. Therefore, the aim of this review paper is to propose such theoretical framework; Leventhal’s Common-sense model of self-regulation, and to review findings of previous studies in the area integrating them in the proposed model. According to this model, ageing and age-related changes in the self, affect health-related cognitions and behaviours. Health information seeking may be conceptualized as a coping response to both health threat and emotional discomfort, which has consequences on illness representations (identity, cause, consequences, control, and timeline), health behaviours and outcomes. Special emphasis was placed to a way in which health information seeking online can result in health anxiety according to the proposed model. Finally, avenues for future research are provided and their practical implications considered.
A Reconfigurable Polarization—Frequency Supershape Patch Antenna with Enhanced Bandwidth

In this article a reconfigurable antenna for WLAN/WiMAX applications is presented. A super-shape radiator of an ellipsis shape is used to achieve wider intrinsic bandwidth compared to the classical rectangular patch antenna, while the dimensions remain comparable. The proposed antenna is fed at two points exciting both horizontal and vertical polarization but in different operating frequencies. To achieve wider bandwidth, as a whole but also for each polarization, the symmetrical feeding points for each excitation are also employed with a proper feeding network. PIN diodes are also used in the feeding network to provide the option of narrower bandwidth. The antenna substrate is Rogers RO4003C with dielectric constant εr = 3.55 and dissipation losses tanδ = 0.0027 with height h = 1.524 mm. The antenna operates in the range of 2.3 GHz to 2.55 GHz but, using the proposed procedure, it can be designed for different frequency ranges.
Effect of Light Spectrum on Gas Exchange, Growth and Biochemical Characteristics of Einkorn Seedlings

The use of Light Emitting Diode (LED) lights in microscale vegetable production is more and more widespread. In this context, the effect of light spectrum on photosynthesis, growth, shoot yield, pigment content, and nutritional status of einkorn seedlings (Triticum monococcum L. ssp. monococcum), germinated and grown in a nutrient solution, was investigated. Plants were subjected to six different LED light treatments, all having a photon flux density (PFD) of 200 μmol m−2 s−1. Two light treatments were monochromatic (red or blue), three dichromatic (blue and red in the proportion), and one of a wider spectrum (selected as a control). All the light treatments affected the morphological, biochemical, and nutritional status of einkorn seedlings. Overall, the dichromatic treatments were the most effective in stimulating biomass production, CO2 assimilation, and evapotranspiration, as well as contents in chlorophyll a and b and carotenoids, and additionally nitrogen, phosphorous, manganese, iron, and zinc. These results are of relevance for the beneficial effects of dichromatic LED treatments in maximizing einkorn shoot yield and nutritional values, and in limiting energy consumption in indoor cultivation.
The effects of moral context on the colours of guilt and pride

ABSTRACT There is little evidence on what colours are associated with moral emotions of guilt and pride and how a change in moral context alters colour-emotion associations. We have addressed this by manipulating the context of (im)moral vs. environmentally (un)friendly behaviours. This is because environmental behaviours are classified as moral, yet they are often driven by different moral motives. We wanted to find out whether this difference could be captured by colour-emotion associations with guilt and pride. We have used an online colour picker to examine over 400 UK participants. The results of the RGB colour model revealed that guilt was most commonly associated with red, black, green, and violet colours. However, the colours of immoral behaviours were much darker than the colours of environmentally unfriendly behaviours. In contrast, pride in moral behaviours was mostly associated with pink, violet, green and blue, whereas pride in environmentally friendly behaviours was mostly paired with green, suggesting that moral context, indeed, has an impact on colour-emotion associations of guilt and pride. In addition, our study has uncovered that colour-emotion associations of guilt and pride are comprised of a certain colour signature, rather than a single colour, and this signature varies with the alteration of context. Our study contributes to developing research in both colour and environmental fields.
New directions in treatment of the ischemic stroke

Stroke remains a leading cause of death and disability worldwide. The cause is decrease or total blocking of blood perfusion in brain and fast recognition is essential to conduct proper treatment. Currently commonly used methods are thrombolysis and mechanical thrombectomy, which high efficacy is observed only if they are performed within a few hours of the first symptoms. Hence loads of people, who are diagnosed later, become unable to undergo effective treatment. In the study are presented pathogenesis, epidemiology, classification, diagnosis and current treatment of the disease, but the main aim of the study is to present the results of the reports on new treatments for ischemic stroke. The research method is a review of the available literature published in PubMed, UpToDate and Google scholar databases. In the study were reviewed new methods, which can be alternative for currently used ones. They are small molecules including fluoxetine, aripiprazole, L-DOPA, cholinergic and noradrenergic drugs, growth factors (HCG, EPO), monoclonal antibodies, allogenic stem cells, neurostimulators, robotic therapy and telerehabilitation. They give hope for curing a larger number of patients and improving effects of rehabilitation after ischemic stroke. However most of the methods, which are presented in this study require the use of tests that will allow checking their safety and application.