Miracle-dz/UniFAR-FTUs huggingface dataset:
Bioactive Macrocyclic Ni(II) Metal Complex: Synthesis, Spectroscopic Elucidation, and Antimicrobial Studies

Abstract A macromolecule schiff base derived from 3-acetyl-2H-benzo[h] chromen-2-one and naphthalene-1,8-diamine and its binuclear macrocyclic Ni(II) metal complex are reported. The ligand behaves as a pentadentate ligand when it coordinates with the metal ion as confirmed by different physical and spectroscopic techniques. Physicochemical and photophysical parameters such as extinction coefficient, oscillator strength, transition dipole moment, stokes shift, and fluorescence quantum yield of the binuclear Ni(II) metal complex were evaluated in the different solvents on the basis of solvents polarity. The thermal decomposition of the metal complex has been studied by thermogravimetric (TGA) and differential calorimetry (DSC). The macrocyclic Ni(II) metal complex was also used to determine of critical micelle concentration (CMC) of cationic and anionic surfactant such as cetyltrimethyl ammonium bromide (CTAB) and sodium dodecyl sulfate (SDS). The antibacterial behavior of the ligand and its metal complex revealed that they are active against both Gram-positive and Gram-negative bacteria, comparable to that of the reference drug Tetracycline. Metal complex showed enhanced activity compared to the ligand.
Assessment of Hand Function: The Relationship between Pegboard Dexterity and Applied Dexterity

The relationship between pegboard dexterity and applied dexterity was investigated by examining performance on the Nine-Hole Pegboard Test and on functional tasks from the Applied Dexterity section of the Arthritis Hand Function Test. Subjects were 395 adult volunteers aged 20–79 years, stratified by age and gender. Significant correlation coefficients were obtained for pegboard dexterity and applied dexterity at p < . 01 for the sample as a whole. However, when the sample was examined by age groups, no significant relationships were found for the 20–29 years group. Pegboard tests are quick and inexpensive assessment tools, but if they have no relationship to the functional use of the hands they may be of questionable value. The results of this study suggest that the Nine-Hole Pegboard Test may be a useful screening device for detecting hand dysfunction related to dexterity.
A Recessive Mutation in the Insulin Gene in Neonatal Diabetes

Neonatal diabetes (ND) is a form of monogenic diabetes that occurs during the first 6 months of life. A recent study estimated its minimum incidence as 1 in 90 000 population (1). ND is clinically divided in two forms: transient ND (TND) and permanent ND (PND) which is caused by several genetic defects (2). Mutations in KCNJ11, ABCC8, and insulin gene (INS) are the main causes of PND (2). KCNJ11 and ABCC8 encode the subunits of the ATP-sensitive potassium channel (K(ATP)) of the pancreatic β-cells. Loss of insulin secretion occurs due to activating mutations of these subunits (3). INS mutations are associated with PND and other clinical conditions such as type 1b diabetes, maturity onset diabetes of the youth (MODY), type 2 diabetes, and TND (4). Here, we report a case of PND due to recessive inheritance INS mutation accompanied by diabetic ketoacidosis (DKA). Case Report
Oral changes in Diabetes – a review

Diabetes mellitus is a chronic disease affecting all age groups and one of the leading causes of mortality and morbidity worldwide. Many chronic macrovascular and microvascular complications of diabetes have been reported in the literature with few reports on diabetes and associated various oral soft tissue abnormalities. In this review, the known correlations between oral disease and diabetes mellitus are highlighted with the aims to increase the awareness of oral changes, complications of diabetes mellitus and to emphasize on need of studies to control these complications. It treats in depth some of the complications such as periodontal disease, fungal infection and salivary dysfunction.
Analysis of Failed Surgical Management of Fractures of the Base of the Fifth Metatarsal Distal to the Tuberosity: The Jones Fracture

Failure of surgical management of fractures of the base of the fifth metatarsal distal to the tuberosity is uncommon. Only one such failure has been reported in the literature to date. The purpose of this article is to present the clinical course of 11 patients with failure of surgically managed Jones fractures reviewed by the senior author (J.S.T.). Surgical management was complicated by delayed union in three patients, refracture in seven patients, and nonunion in one patient. The 11 procedures were divided between two established techniques: (1) intramedullary screw fixation (N = 6) and (2) inlaid corticocancellous bone graft (N = 5). In the six intramedullary fixation procedures, using other than a 4.5-mm ASIF malleolar screw for internal fixation correlated with failure. In the five inlaid bone graft procedures, undersized corticocancellous grafts and incomplete reaming of the medullary canal correlated with failure. Also, after both procedures, early return to vigorous physical activity is believed to have played a role in delayed union and refracture.
O caminho para eliminac ¸ão da transmissão vertical do HIV

Nearly 1 in 20 adults in sub-Saharan Africa arecurrently living with the infection. HIV represents one of theworld’s most serious health problems.The WHO global health sector strategy on HIV/acquiredimmunodeﬁciency syndrome (AIDS) has identiﬁed fourstrategic directions to guide countries’ HIV response toachieve theUnited Nations’ Millennium Development Goalof halting thespread of HIV/AIDS. A core element of strate-gic direction one was the elimination of new HIVinfectionsin children.
Regulation of T follicular helper cells by CD8+ regulatory T cells reduces pro-atherogenict tertiary lymphoid organ formation in apolipoprotein E KO mice

Tertiary lymphoid organs (TLOs), composed of B cell follicles, develop in the adventitia of atherosclerotic arteries. However, it is not known whether TLOs play an effective role in atherogenesis. In order to address this issue it is necessary to modulate the formation/function of these ectopic B cell follicles within the adventitia. Recent studies have shown that the function of germinal center B cells in secondary lymphoid organs (SLO) is tightly controlled by the Qa-1-restricted CD8+ T cells (CD8+ Treg) which regulate T follicular helper (TfH) cells function. We therefore evaluated whether regulation of TfH by CD8+ Treg can control the development of TLOs and, in turn, of atherogenesis in hypercholesterolemic (ApoE°) mice. We firstly found that the frequency of CD8+ Treg in ApoE° mice significantly decreases with age in the spleen and peripheral lymph nodes of this model. We therefore crossed ApoE° mice with the D227K-Tg mice in which, due to a Qa-1 point mutation, the CD8+ Treg are unable to control the development/function of TfH cells. ApoE° were compared with ApoE°/D227K-Tg littermates (n=5-12/group) at 8, 15 and 35 weeks of age. Qa-1 mutation increased the TfH cell population in SLO of ApoE°/D227K-Tg as compared to ApoE° mice. This effect was accompanied by an increase in the percentage of activated/memory CD4+ and CD8+ T cells and of B cells in lymph nodes of ApoE°/D227K-Tg, at 15 and 35 weeks of age. In parallel, lesion development was accelerated: atherosclerotic plaques in the aortic root of ApoE°/D227K-Tg mice were 2-fold greater than those of ApoE° mice. Immunofluorescent analysis of adventitial whole mounts revealed a greater incidence of TLOs (organized B cell follicles) in ApoE°/D227K-Tg than in ApoE° mice. Our data therefore suggest that CD8+ Treg control the development of adventitial pro-atherogenic TLOs in ApoE° mice through their regulatory action on TfH cells.
TECHNIQUES FOR DETECTION OF SOLITARY PULMONARY NODULES IN HUMAN LUNG AND THEIR CLASSIFICATIONS -A SURVEY

Lung cancer is proving to be a catastrophic threat to the mankind and is main cause of deaths among other cancer related casualties. The presence of solitary pulmonary nodules in human lungs in the form of benign or malignant determines the gravity of lung ailment. This survey focusses on different techniques used to detect and classify the lung nodules which in turn will assist the domain experts for better diagnosis. Among many imaging modalities Computed Tomography (CT) being the most sought after because of its high resolution, isotropic acquisition which helps in locating the lung lesions. Since the volume of the CT scans are very large, Computer Aided Detection/Diagnosis (CAD/x) has more advantages in addition to manual interpretation with respect to speed and accuracy. This paper attempts to summarize various methods that have been proposed by several authors over the years of their research.
Development of vaccines against peste des petits ruminants: CIRAD's achievements and future challenges

CIRAD, France, in collaboration with the Pirbright Institute, United Kingdom, was the first laboratory to develop a live attenuated vaccine against peste des petits ruminants (PPR). This vaccine available in the 1980s was shown to provide a life-long immunity after a single injection [5] and is now widely used in sheep and goats. New vaccines are in development, more specifically thermotolerant vaccines for use in tropical conditions and DIVA (differentiating infected from vaccinated animals) vaccines to gain virus-free status more easily and rapidly. This paper reviews most of the current and recently developed vaccines at CIRAD and emphasises their adequate delivery and utilisation in the field, for successfully decreasing the incidence of PPR. (Resume d'auteur)
Zachowania zdrowotne a umiejscowienie kontroli zdrowia u pacjentów z rozpoznanym nadciśnieniem tętniczym Health behaviors and health locus of control in patients diagnosed with arterial hypertension

Summary Background Hypertension is a widespread chronic disease. Proper diet, maintaining a healthy weight and avoiding tobacco and alcohol can, to a large extent, protect against this disease. Effectiveness in complying with the recommendations regarding health-related behaviors depends on beliefs about the health locus of control of each person. Aim of the study was to show the relationship between health behavior and preferred health locus of control in patients with arterial hypertension, as the exponent in maintaining optimal health. Material and methods The study was conducted among 97 people with diagnosed hypertension in the Clinic of Cardiology and Cardiac Surgery and Clinic of Internal Medicine of 10th Military Clinical Hospital with Polyclinic in Bydgoszcz. Health behavior was determined using the Inventory of health behaviors by Juczynskiego and health locus of control was assessed using a MHLC questionnaire version B, in the adaptation of Juczynski. Results Individuals with an external locus of control have better health habits, are more interested in prevention, have more positive attitude and pay more attention to health practices than those with internal health locus of and people who deem that destiny is responsible for their health. Conclusions Obtained results may allow better identification of the needs of people with hypertension. This study may also help in planning of education, which will result in an increase in the level of knowledge, helping patients in caring for their own health.
Integrating Balance and Postural Stability Exercises into the Functional Warm-up for Youth Athletes

SUMMARY THE GOAL OF THE FUNCTIONAL WARM-UP IS TO STIMULATE SENSORY AND MOTOR COMPONENTS RELATED TO PREPARATORY (FEED-FORWARD) AND REACTIVE (FEED-BACK) SYSTEMS THROUGH FUNCTIONALLY INTEGRATED MOVEMENT PATTERNS. THIS ARTICLE PRESENTS BALANCE AND POSTURAL STABILITY EXERCISES THAT ARE EASILY IMPLEMENTED INTO THE FUNCTIONAL WARM-UP AS A MOVEMENT PREPARATION STRATEGY FOR YOUTH ATHLETES.
Gehirn und Seele2)

Von Dr. P. Schultz, Assistenten am physiologischen Institut in Berlin. Es war eine glückliche Intuition des Verfassers im Beginn seiner wissenschaftlichen Laufbahn, dass er die Kenntniss von dem Bau und der Verrichtung des Gehirns auf die Erforschung seiner Entwicklung, d. h. nicht etwa von der ersten Anlage an, sondern unmittelbar vor und nach der Geburt gründete. Der Aufbau desselben lasst sich zu dieser Zeit durch den Process der Markscheideiibildung verfolgen und wird beherrscht von dem Gesetz: . ,Leitungen von verschiedener functioneller Bedeutung erhalten die Markseheiden zu verschiedenen Zeiten. " Die fertigen, also mit Markscheiden versehenen Leitungen lassen sich nun dadurch genau bestimmen, dass die Markscheiden durch die Weigert'sche Hümatoxylinrnethode gefärbt werden. Man sieht dann an so behandelteu Präparaten aus dem Gehirn Neugeborener die reifen Nervenbündel als blaue Züge zwischen den ungefärbten unreifen Leitungen, welche glasartig durchscheinen, verlaufen, so dass man sie auf grosse Strecken verfolgen kann. Eine gedrängte Uebersicht über die wichtigsten Ergebnisse einer nahezu z\vanziährigen eingehenden Arbeit auf diesen Prinzipien giebt das vorliegende Werkcheii. Sie lassen sich dahin zusamnienfassen: Beim neugeborenen Kind sind nur die niederen Hirutheile (verlängertes Mark, Kleinhirn, Vierhügel und ein Theil der Grosshirnganglien) in ihrer Entwicklung völlig abgeschlossen. Hier haben wir nur die Triebe localisirt zu denken, ausserdem wird ein statisch-mechanisches Bild über dcii jeweiligen Zustand des Körpers erzeugt. Im Grosshirn sind dagegen nur wenige Nervenleitimgen angelegt. Es entwickeln sich nun von der Körperoberfläche Bahnen von den einzelnen Sinnesorganen nach der grauen Rinde des Grosshirns, die Sinnesleitungen, der Geruchssinn zuerst,
Establishing Local Reference Dose Values and Optimisation Strategies

The revised EC Patient Directive 97/43 EURATOM introduces the concepts of clinical audit, diagnostic reference levels and optimisation of radiation protection in diagnostic radiology. The application of reference dose levels in practice involves the establishment of reference dose values as actual measurable operational quantities. These values should then form part of an ongoing optimisation and audit programme against which routine performance can be compared. The CEC Quality Criteria for Radiographic Images provides guidance reference dose values against which local performance can be compared. In many cases these values can be improved upon quite considerably. This paper presents the results of a local initiative in the North West of the UK aimed at establishing local reference dose values for a number of major hospital sites. The purpose of this initiative is to establish a foundation for both optimisation strategies and clinical audit as an ongoing and routine practice. The paper presents results from an ongoing trial involving patient dose measurements for several radiological examinations upon the sites. The results of an attempt to establish local reference dose values from measured dose values and to employ them in optimisation strategies are presented. In particular emphasis is placed on the routine quality control programmes necessary to underpin this strategy including the effective data management of results from such programmes and how they can be employed to optimisation practices.
Pitfalls in the rapid diagnosis of positive blood culture

Bacteraemia and sepsis are among the most serious health problems with an incidence that is increasing worldwide, and brings about considerable economic burden. Blood cultures have traditionally been considered as the gold standard and are of great diagnostic value in defining bacteraemia and sepsis. The introduction of automated blood culture systems has provided continuous growth monitoring and improved the yield and shortened the time to positivity. When blood cultures turn positive, how to process the positive blood culture bottles is an important task for the microbiological laboratory. Technicians are challenged to process flagged positive blood culture at different circumstances. This article addresses relevant pitfalls associated with positive blood culture. Microbiological laboratory should have guidelines and strategies that can provide appropriate handling of positive blood culture.
Distress Management Clinical Practice Guidelines in Oncology

The integration of psychosocial care into the routine care of all patients with cancer is increasingly being recognized as the new standard of care. These NCCN Clinical Practice Guidelines in Oncology for Distress Management discuss the identifica tion and treatment of psychosocial problems in patients with cancer. They are intended to assist oncology teams identify patients who require referral to psychosocial resources and to give oncology teams guidance on interventions for patients with mild distress to ensure that all patients with distress are recognized and treated. (JNCCN 2013;11:190–209)
Aspects of welfare related to sows housed in individual pens. Relato de Caso

The overall objective of this research is to evaluate the welfare of sows bred in an individual cell confinement system, exploring various positive and negative aspects of this type of accommodation. For this purpose, parameters such as social contact, stereotyping, physical comfort, exercising possibilities, movement and predisposition to diseases are discriminated. A data surveying method was employed, as well as articles on the subject, which were used as bibliographical references. After reading, a comparison of the results was performed in order to formulate the discussion herein. According to the results obtained, the individual cell confinement system brings harm to animal welfare, since it restrains social contact with other individuals of the same species, causes thermal discomfort due to lack of stall ventilation and affects animal exercising space, as the stall is excessively small. It also leads to low immunity of the sows due to constant exposure to stressful situations. The presence of stereotypes also proved to be more common in matrixes bred in individual cells than matrixes bred in collective cells or in free range breeding. In order to mitigate the negative aspects of breeding in individual cell confinement systems, measures for increasing animal welfare are proposed, such as environmental enrichment and changes in cell architecture and dimensioning. Among other options for increasing sow welfare is the implementation of collective cells, or the Intensive Free Range Swine Breeding System. Keyword: confinement, stress, injuri. ____________________________ 1 Alunos do curso de Graduação em Medicina Veterinária, Faculdade de Ciências Agrárias e Veterinária UNESP/Jaboticabal, São Paulo, Brasil. 2 Pós-graduanda do Programa de Medicina Veterinária, Faculdade de Ciências Agrárias e Veterinária UNESP/Jaboticabal, São Paulo, Brasil. 3 Professor Assistente Doutor do Departamento de Clínica e Cirurgia Veterinária, Faculdade de Ciências Agrárias e Veterinária UNESP/Jaboticabal, Via de Acesso Prof. Paulo Donato Castellane, s/n. CEP 14884-900, São Paulo, Brasil, e-mail: luis.guilherme@fcav.unesp. br *Autor para correspondência Recebido em 01/07/2014. Aprovado em 20/09/2014 Oliva et al., Revista Brasileira de Higiene e Sanidade Animal (v.8, n.3) p. 89 –104, jul set (2014)
Science data vaults in monetDB: a case study

Nowadays, the amount of data generated by scientific instruments (data captured) and computer simulations (data generated) is very large. The data volumes are getting bigger, due to the improved precision of the new instruments, or due to the increasing number of collecting stations. This requires new scientific methods to analyse and organize the data. However, it is not so easy to deal with this data, and with all the steps that the data have to get through (capture, organize, analyze, visualize, and publish). A lot of data is collected (captured), but not curated (organized, analyzed) or published. In this thesis we focus on the astronomical data, typically they are stored in FITS files (Flexible Image Transport System). We will investigate the access and querying of this data by means of database technology. The target database system is MonetDB, an open-source column-store database with record of successful application to analytical workloads and scientific applications (SkyServer). Given the results of the experiments, the perceptible superiority presented by MonetDB over STILTS when more computation is required, and the success obtained during the execution of the use case proposed by an astronomer working at the CWI, we can declare that MonetDB is a powerfull and robust alternative to manipulate and access information contained in FITS files.
Ebe ve Hemşirelere Verilen Eğitimin Kadina Yönelik Aile İçi Şiddete İlişkin Tutumlarina Etkisi The Effect of Education Given to Midwifes and Nurses on Their Attitudes of Domestic Violence against Women

Aim: The objective of this study was to determine the effect of education received by midwives and nurses on their attitudes regarding the violence against women. Material and Method: The study was conducted as an experimental model with pretest-posttest experimental and control group. The population of the study consisted of midwives and nurses working in 18 Family Health Centers in the city center of Erzurum. All midwives and nurses (84 individuals) who agreed to participate in the study were included in the study without selecting any sample group. A pretest was performed to midwives and nurses in the experimental and control groups. And then the midwives and nurses in the experimental group were trained about the violence against women and at the end of the training, they were given training manuals. Once the trainings were over, a posttest was performed to the experimental and control group. The "Questionnaire form", "Attitude towards Violence Scale" and "Scale of the Attitude of Medical Personnel towards the Occupational Roles of Violated Women" were used to collect the data. Results: It was observed that the midwives and nurses in the experimental group had considerably lower posttest mean scores in all subscales and the overall Attitude towards Violence Scale, compared to the pretest mean scores (p<0.001). It was also observed that the midwives and nurses in the
Cortisol and Growth Hormone Responses to Exercise

Cortisol and growth hormone (GH) are released in response to a variety of pharmacologic and physio-logic stimuli. Secretion of cortisol and GH are inﬂuenced by age, gender, time of day, nutrition, sleep, body composition, and ﬁtness level. Exercise is one of the most potent stimulators for release of these hormones. A single session of exercise of sufﬁcient intensity will result in dramatic increases in cortisol and GH concentrations in most individuals and may take a few hours to recover back to baseline levels. Cortisol and GH are necessary for optimal exercise performance, which is most evident in chronic cortisol and GH deﬁciency. In deﬁcient individuals, replacement therapy with cortisol or GH restores normal exercise performance. Exercise training can substantially alter the degree of perturbation of the hypothalamic-pituitary axis. The cortisol response pattern to exercise has been considered to be predictive of an individual’s adaptation to other forms of stress. This review discusses the cortisol and GH responses to exercise, the factors affecting
Cerebral Blood Flow Velocity with Induction Dose of Intravenous Anesthetics

Cerebral Blood Flow Velocity with Induction Dose of Intravenous Anesthetics No studies are available to compare directly the changes of cerebral blood flow (CBF) by induction doses of thiopental, propofol, midazolam and ketamine. We hypothesized that CBF would decrease in the order of thiopental, midazolam, and propofol, but increase with ketamine at induction of anesthesia. The present study compared the change of CBF with induction doses of these anesthetics by measuring CBF velocity (CBFV) using Transcranial Doppler.