Miracle-dz/UniFAR-FTUs huggingface dataset:
Aplicación de realidad aumentada en la enseñanza de la física

Esta investigacion describe el desarrollo de una aplicacion de software que usa la tecnologia de Realidad Aumentada para la ensenanza de la fisica. Se diseno y desarrollo el software tomando como caso de estudio una practica relacionada con el aprendizaje del tema Tiro Parabolico del Curso Fisica II que se imparte a las distintas carreras del Instituto de Ingenieria y Tecnologia. Se probo la practica desarrollada con realidad aumentada en un grupo experimental y en otro grupo control se desarrollo la practica en el modo habitual, sin uso del software. Se midio el aprendizaje de ambos grupos, obteniendose una ganancia de 1.22 en el en el grupo experimental y 0.78 en el grupo control. Palabras clave:
Evaluation of Packaging Effect on MEMS Performance: Simulation and Experimental Study

The thermal cure required for die attach during microelectro-mechanical systems (MEMS) packaging causes thermal mismatch that induces undesirable stresses and strains in surface micromachined structures, which may adversely affect the performance and reliability of the packaged component. Understanding the influence of the packaging process is, therefore, critical for successful device design. This paper analyzes the influence of the die attach process on the electromechanical behavior of doubly-anchored surface micromachined beams. A number of different adhesive materials were considered, and the results of parametric studies on the effects of die attach on the pull-in behavior of beams of various lengths, widths, and anchor types are presented. An upward shift in pull-in voltage of the studied devices was observed in both simulation and experiment; modelled and measured data were found to correlate closely.
Primary Endometrioid Stromal Sarcoma of the Ovary: A Clinicopathologic Study of 27 Cases With Morphologic and Behavioral Features Similar to Those of Uterine Low-grade Endometrial Stromal Sarcoma

Twenty-seven endometrioid stromal sarcomas of the ovary from patients 38 to 76 (mean 56) years of age are reported. The tumors were unilateral in 20 cases and bilateral in 7. They were solid (9), solid and cystic (9), or predominantly cystic (6) when this information was known and ranged from 1 to 20 (mean 9.5) cm. The solid areas typically had a tan-yellow cut surface, with areas of hemorrhage and/or necrosis noted in 6; however, in addition, blood was often present in the cyst lumens. On microscopic examination, the predominant and frequently exclusive pattern was a diffuse growth of small cells with interspersed arterioles, the latter appearing round to elongated. A fibromatous pattern was present in 14 of the tumors but was extensive in only 3. A vague nodular growth was observed in 10 tumors but was never striking; a storiform growth was seen in 2 tumors, being conspicuous in 1. Hyaline plaques were present in 10 tumors but were striking in only 2. Sex cord-like or smooth muscle differentiation was seen in 7 and 6 tumors, respectively, being striking in 2 and 3 of them. Foam cells were present in 6 tumors. The tumors showed minimal cytologic atypia. The mitotic index ranged from <1 to 17/10 high-power fields (HPF), being <1/10 HPF in 12, 1 to 5/10 HPF in 9, 6 to 10/10 HPF in 2, and >10/10 HPF in 4 tumors. Infarct-type necrosis was noted in 12 tumors. Hemorrhage, typically recent, was seen in 20 cases, being conspicuous in 5. Ovarian endometriosis was intimately associated with the tumor in 16 cases. Seven patients had stage I tumors, 5 stage II, 13 stage III, and 2 stage IV. Follow-up information was available for 21 patients; 10 were alive and free of disease from 4 to 21 years postoperatively (follow-up being ≥11 y in 5); 6 were alive with disease from 1 to 22 years postoperatively; 5 patients are known to have died of disease, with the interval being unknown in 1, and 2, 4, 13, and 17 years in the others. Follow-up information was unavailable in the remaining 6 patients. These findings indicate that these tumors, as in the uterus, often have an indolent course with a better prognosis than other ovarian sarcomas, indicating the importance of correct diagnosis. The differential diagnosis of these neoplasms is in the first instance with a metastasis from the uterus; knowledge of the status of the uterus is paramount in this distinction. Associated ovarian endometriosis suggests a primary tumor. When a primary ovarian origin is determined, the differential diagnosis is most often with a sex cord-stromal tumor, particularly a granulosa cell tumor because of a diffuse growth of cells with scant cytoplasm.
Socialt sårbare kræftpatienters behov for inddragelse i egen behandling, pleje og forløb, samt interventioner der sigter mod at fremme denne inddragelse: En gennemgang af den internationale litteratur

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Draft Genome Sequence of Deinococcus indicus DR1, a Novel Strain Isolated from a Freshwater Wetland

ABSTRACT Deinococcus indicus strain DR1, a red-pigmented, arsenic- and radiation-resistant bacterium, was isolated from a water sample of the Dadri wetland, Uttar Pradesh, India. Here, we report a draft genome sequence of this strain, which may provide useful information regarding the genes and pathways involved in heavy-metal bioremediation.
Sequence of the human GATA-1 promoter.

The hematopoietic-specific transcription factor GATA-1 participates in control of erythroid-expressed genes (1) and is required for erythroid development in vivo (2). Recently Nicolis et al. (3) reported human GATA-1 gene promoter sequences. Homology to mouse GATA-1 sequences (2) was noted only in the proximal promoter and in an upstream region containing a double GATA-site implicated in autoregulation (4). Their sequence of the human GATA-1 promoter differs from that we have obtained with respect to the omission of 121 bp, which display substantial similarity with the mouse (Figure 1, bracketed region). Confirmation that this region is indeed part of the promoter was achieved by PCR (Figure 2) using two independent human GATA-1 genomic clones (lanes 1, 2, 8, 9) and total human DNA samples (lanes 3 -7) . The revised human promoter sequence brings the two mammalian sequences into closer alignment (Figure 2), and predicts strong functional similarities between human and mouse GATA-1 regulatory regions.
Ecto-5′-Nucleotidase (CD73)-Mediated Formation of Adenosine Is Critical for the Striatal Adenosine A2A Receptor Functions

Adenosine is a neuromodulator acting through inhibitory A1 receptors (A1Rs) and facilitatory A2ARs, which have similar affinities for adenosine. It has been shown that the activity of intracellular adenosine kinase preferentially controls the activation of A1Rs, but the source of the adenosine activating A2ARs is unknown. We now show that ecto-5′-nucleotidase (CD73), the major enzyme able to convert extracellular AMP into adenosine, colocalizes with A2ARs in the basal ganglia. In addition to astrocytes, striatal CD73 is prominently localized to postsynaptic sites. Notably, CD73 coimmunoprecipitated with A2ARs and proximity ligation assays confirmed the close proximity of CD73 and A2ARs in the striatum. Accordingly, the cAMP formation in synaptosomes as well as the hypolocomotion induced by a novel A2AR prodrug that requires CD73 metabolization to activate A2ARs were observed in wild-type mice, but not in CD73 knock-out (KO) mice or A2AR KO mice. Moreover, CD73 KO mice displayed increased working memory performance and a blunted amphetamine-induced sensitization, mimicking the phenotype of global or forebrain-A2AR KO mice, as well as upon pharmacological A2AR blockade. These results show that CD73-mediated formation of extracellular adenosine is responsible for the activation of striatal A2AR function. This study points to CD73 as a new target that can fine-tune A2AR activity, and a novel therapeutic target to manipulate A2AR-mediated control of striatal function and neurodegeneration.
HBA score in relation to donor semen profiles and live birth rates: a preliminary study

Abstract We sought to determine whether sperm donor selection could be improved by using the hyaluronan binding assay (HBA) score to predict live birth rates (LBRs) in donor insemination treatments. Thirty donor samples were included: five fresh samples to assess whether HBA score is affected by cryopreservation and 25 frozen samples from donors whose sperm gave rise to known live births, divided into three groups, with success rates ≥50%, <50–33% and <33%, to examine whether HBA score correlates with LBRs. Correlations with semen analysis parameters, as well as donor demographic factors, known causes of patient subfertility and/or the type of treatment provided were also assessed. There was no significant difference in the mean HBA score pre- and post-cryopreservation (p = 0.998) nor in the HBA score of the three different outcome groups (p = 0.89). HBA score was not significantly affected by other semen analysis parameters (r2=0.394, p = 0.127) or any of the other examined factors. This was the first study to investigate HBA score for cryopreserved donor samples with known LBRs. HBA score was not correlated with LBRs in this small pilot study. Larger studies are required to validate HBA score as a tool for sperm donor selection and predictor of LBRs.
A 60 GHz CMOS-SOI integrated antenna with coupled patch in a QFN package

A 60-GHz folded dipole antenna integrated with a transceiver on a 65-nm CMOS-SOI chip for short range and low power wireless communications is presented. The chip is packaged in a QFN48L pre-molded cavity package with removable lid. Radiating patch elements coupled to the on-chip folded dipole are fabricated under the package lid to improve the radiation performances. The experimental radiation patterns and gain values show an excellent agreement with the simulations. An antenna gain up to 3-5.7 dBi at 60 GHz is demonstrated with good impedance matching over a 13% bandwidth.
A fully encapsulated waveguide coupled passive imaging W-band radiometer module with RF frontend IC in a SiGe-BiCMOS technology

Heterodyne and direct detection radiometer receivers at 94 GHz have been realized in a 130 nm Si/SiGe BiCMOS process. They have been assembled into fully self-contained metal housings with a waveguide flange for the antenna connection. The receivers, which employ a SiGe LNA with below 4 dB noise figure, show overall responsivities of 620 μV/K and 380 μV/K respectively.
Multi-architecture profiler for Android

Performance and energy consumption are well-known constraints of modern embedded systems, thus, application analysis in early stages of the development cycle is mandatory. However, the few available tools to evaluate the behaviour of an application considering different architectures are not able to provide a complete solution for this task. In this context, this work presents a multi-architecture profiling tool for Android applications, which fully supports ARM, MIPS, and x86 architectures. It provides a wide range of information per application, including energy consumption, execution time and other statistics. For that, we have extended the Android Emulator QEMU and developed post-processing tools. As case study, we have compared different architectures in terms of performance and energy consumption. By the use of the proposed tool, we show that, given a fixed energy budget, a different amount of applications can be executed depending on how they were implemented, which varies according to the processor.
Hyaluronan: its nature, distribution, functions and turnover

Fraser JRE, Laurent TC, Laurent UBG (Monash University, Clayton, Victoria, Australia; and University of Uppsala, Uppsala, Sweden). Hyaluronan: its nature, distribution, functions and turnover (Minisymposium: Hyaluronan). J Intern Med 1997; 242: 27–33.
Driving Interactive Graph Exploration Using 0-Dimensional Persistent Homology Features

Graphs are commonly used to encode relationships among entities, yet, their abstractness makes them incredibly difficult to analyze. Node-link diagrams are a popular method for drawing graphs. Classical techniques for the node-link diagrams include various layout methods that rely on derived information to position points, which often lack interactive exploration functionalities; and force-directed layouts, which ignore global structures of the graph. This paper addresses the graph drawing challenge by leveraging topological features of a graph as derived information for interactive graph drawing. We first discuss extracting topological features from a graph using persistent homology. We then introduce an interactive persistence barcodes to study the substructures of a force-directed graph layout; in particular, we add contracting and repulsing forces guided by the 0-dimensional persistent homology features. Finally, we demonstrate the utility of our approach across three datasets.
On the differentiation of anthrax bacilli from Bacillus cereus.

led Smith, Gordon and Clark (1952) to suggest that nonvirulent strains of B. anthracis may actually be identical with B. cereus, and further that it may be proper to regard virulent anthrax bacilli as pathogenic variants of the supposedly more stable parent species, B. cereus. Recently Brown et al (1955, 1956, 1958) have presented new evidence in support of these concepts. Brown, Moody, Treece and Smith (1958) described an anthrax-like disease produced in laboratory animals as the result of inoculating rapidly multiplying B. cereus which had apparently been transformed into capsulated bacilli capable of causing "the gross pathology of anthrax. " In the present paper results of our further studies will be presented. By use of
Some aspects of the adult urinary stone problem in Great Britain and Northern Ireland.

Summary In a collection of 856 urinary calculi from Great Britain and Northern Ireland, the most abundant and frequently occurring crystalline constituents are the mono- and di-hydrates of calcium oxalate and hydroxy- and carbonate-apatite. On the basis of composition, most stones can be assigned to a few well-defined groups. The most common composition type, accounting for 34% of the collection, is that composed of calcium oxalate+calcium phosphate. The oxalate can be either or both of the hydrates, often both are present, but the calcium phosphate is generally hydroxyapatite. Stones consisting of pure calcium oxalate make up 27% of the total, while those comprised of struvite+calcium phosphate contribute 17%. In the latter variety the calcium phosphate is almost invariably carbonate-apatite. The other group considered consists of the pure calcium phosphate calculi which account for 7% of the collection. The incidence of stones in relation to their site in the urinary tract and the patient's age and sex has been investigated, together with the effect of the stone site, patient's age and sex on the distribution of calculi in the main composition groups and the effect of composition, site, age and sex on the stone weight. Most of these variables have a significant effect on one another. The incidence of stones is also related to daily occupation, professional workers being 10 times more likely to develop urolithiasis than labourers. We thank the Medical Research Council and Nuffield Foundation who financed most of this work and Mr D. Sturt who kindly agreed to the participation of the Computer Centre in this project. We are greatly indebted to Mr N. W. Please for advice and many helpful discussions on the statistics and for carrying out the analysis of variance. Finally, we are grateful to the many surgeons and physicians who provided the stones and the data.
Direct assessment of queen quality and lack of worker suppression in a paper wasp

Assessing a conspecific's potential is often crucial to increase one's fitness, e.g. in female choice, contests with rivals or reproductive conflicts in animal societies. In the latter, helpers benefit from accurately assessing the fertility of the breeder as an indication of inclusive fitness. There is evidence that this can be achieved using chemical correlates of reproductive activity. Here, we show that queen quality can be assessed by directly monitoring her reproductive output. In the paper wasp Polistes dominulus, we mimicked a decrease in queen fertility by regularly removing brood. This triggered ovarian development and egg-laying by many workers, which strongly suggests that brood abundance is a reliable cue of queen quality. Brood abundance can be monitored when workers perform regular brood care in small size societies where each brood element is kept in a separate cell. Our results also show that although the queen was not manipulated, and thus remained healthy and fully fertile, she did not control worker egg-laying. Nevertheless, when workers laid eggs, the queen secured a near reproductive monopoly by selectively destroying these eggs, a mechanism known as ‘queen policing’. By contrast, workers destroyed comparatively few queen-laid eggs, but did destroy each other's eggs.
Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway

The N-end rule finds a physiological function The N-end–rule pathway for protein degradation is a canonical degradation pathway discovered in the 1980s. In recent years, studies have focused on finding novel variant pathways of N-end recognition. The “classical” pathway is blocked by N-terminal acetylation of the substrate. However, in yeast, N-terminal acetylation need not block degradation, because a second pathway can act on acetylated N-termini. But is this alternate pathway a major player in the physiology of mammals? Park et al. now confirm the existence of the alternate pathway in mammalian cells. Most notably, patient-derived point mutations thought to confer hypertension in humans affect susceptibility to this pathway for the encoded protein substrate, Rgs2. Science, this issue p. 1249 A G protein signaling regulator and its hypertension-associated mutants are short-lived physiological substrates of the Teb4 ubiquitin ligase. Rgs2, a regulator of G proteins, lowers blood pressure by decreasing signaling through Gαq. Human patients expressing Met-Leu-Rgs2 (ML-Rgs2) or Met-Arg-Rgs2 (MR-Rgs2) are hypertensive relative to people expressing wild-type Met-Gln-Rgs2 (MQ-Rgs2). We found that wild-type MQ-Rgs2 and its mutant, MR-Rgs2, were destroyed by the Ac/N-end rule pathway, which recognizes Nα-terminally acetylated (Nt-acetylated) proteins. The shortest-lived mutant, ML-Rgs2, was targeted by both the Ac/N-end rule and Arg/N-end rule pathways. The latter pathway recognizes unacetylated N-terminal residues. Thus, the Nt-acetylated Ac-MX-Rgs2 (X = Arg, Gln, Leu) proteins are specific substrates of the mammalian Ac/N-end rule pathway. Furthermore, the Ac/N-degron of Ac-MQ-Rgs2 was conditional, and Teb4, an endoplasmic reticulum (ER) membrane-embedded ubiquitin ligase, was able to regulate G protein signaling by targeting Ac-MX-Rgs2 proteins for degradation through their Nα-terminal acetyl group.
Fast FeatureLess Quaternion-based Particle Swarm Optimization for Object Pose Estimation From RGB-D Images

We present a novel quaternion-based formulation of Particle Swarm Optimization for pose estimation which, differently from other approaches, does not rely on image features or machine learning. The quaternion formulation avoids the gimbal lock problem, and the objective function is based on raw 2D depth information only, under the assumption that the object region is segmented from the background. This makes the algorithm suitable for pose estimation of objects with large variety in appearance, from lack of texture to strong textures, for the task of robotic grasping. We find candidate object regions using a graph-based image segmentation approach that integrates color and depth information, but the PSO is agnostic to the segmentation algorithm used. The algorithm is implemented on GPU, and the nature of the objective function allows high parallelization. We test the approach on different publicly available RGB-D object datasets, discuss the results and compare them with other existing methods.
Filter-embedded four-channel WDM module fabricated from fluorinated polyimide

Filter-embedded four-channel wavelength-division multiplexers for wavelength-division multiplexing (WDM) systems are fabricated from polyimide waveguides. The WDM module has a wide passband of over 30 nm, low insertion loss, and low crosstalk. The insertion loss and crosstalk for each port were less than 4.9 dB and better than -20 dB, respectively. The reliability of the WDM was examined, and it passed the change of temperature and damp heat tests of the International Electrotechnical Commission (IEC) category C.
Linguistic Features of Humor in Academic Writing

A corpus of 313 freshman college essays was analyzed in order to better understand the forms and functions of humor in academic writing. Human ratings of humor and wordplay were statistically aggregated using Factor Analysis to provide an overall Humor component score for each essay in the corpus. In addition, the essays were also scored for overall writing quality by human raters, which correlated (r = .195) with the humor component score. Correlations between the humor component scores and linguistic features were examined. To investigate the potential for linguistic features to predict the Humor component scores, regression analysis identified four linguistic indices that accounted for approximately 17.5% of the variance in humor scores. These indices were related to text descriptiveness (i.e., more adjective and adverb use), lower cohesion (i.e., less paragraph-to-paragraph similarity), and lexical sophistication (lower word frequency). The findings suggest that humor can be partially predicted by linguistic features in the text. Furthermore, there was a small but significant correlation between the humor and essay quality scores, suggesting a positive relation between humor and writing quality. Keywords : humor, academic writing, text analysis, essay score, human rating
Transcription stimulates homologous recombination in mammalian cells

Transcription stimulates homologous recombination in Saccharomyces cerevisiae and has been implicated in the control of recombinational events during the development of mammalian immune systems. Here, we describe a plasmid-based system in which an inducible promoter from the mouse mammary tumor virus is located upstream of heteroallelic neomycin genes carried on two plasmids. Pairs of plasmids are introduced into Chinese hamster ovary cells by electroporation, and recombination is monitored by scoring colonies resistant to the aminoglycoside G418. When transcription is induced with dexamethasone, a synthetic glucocorticoid hormone, and double-strand breaks are introduced at mutation sites, recombination is stimulated sixfold over noninduced levels. Inducing transcription in circular substrates or in substrates cleaved at sites distant from the mutations has no detectable effect on recombination between neomycin genes. Results are presented that are consistent with the observed stimulation of recombination occurring before plasmids integrate into the cellular DNA. Our results are discussed in relation to molecular models for extrachromosomal recombination in mammalian cells.