Miracle-dz/UniFAR-FTUs huggingface dataset:
Evolution of blood pressure and cholesterol in stage 1 hypertension: role of autonomic nervous system activity

Objective Controversy remains concerning the pathogenetic mechanisms for the relationship between sympathetic activity, hypertension and lipid abnormalities. We tested the hypothesis that a condition characterized by sympathetic predominance may affect the evolution of blood pressure and lipids in the early stage of hypertension. Methods We prospectively studied 163 young stage 1 hypertensive individuals and 28 normotensive control individuals. The hypertensive subjects were divided by cluster analysis into two groups according to low frequency and high frequency components of heart rate variability. Large artery and small artery compliance was assessed at the end of the follow-up. Results Fifty-nine subjects showed reduced total power and signs of sympathetic predominance in the resting condition, on standing and during mental stress (group 1). At baseline, they had similar blood pressure and metabolic data to the rest of the group (n = 104, group 2) and a greater white-coat effect (P = 0.03). During a 6-year follow-up, 23.7% of group 1 subjects versus 9.6% of group 2 subjects developed sustained hypertension requiring antihypertensive treatment (P = 0.02). In group 1 subjects, there was also a greater increase in total cholesterol (P = 0.01) than in group 2. In addition, at the end of follow-up group 1 subjects had impaired large artery compliance (P < 0.001 versus group 2). Conclusions These data indicate that a condition characterized by sympathetic predominance may favour the development of sustained hypertension and hypercholesterolemia early in life, and lead to increased susceptibility to vascular complications. They further indicate that the increased white-coat effect is not an innocent phenomenon.
Tip110, the Human Immunodeficiency Virus Type 1 (HIV-1) Tat-interacting Protein of 110 kDa as a Negative Regulator of Androgen Receptor (AR) Transcriptional Activation*

Upon binding to androgen, androgen receptor (AR) can activate expression of target genes through its direct binding to the androgen-responsive elements (AREs), which are located within the target gene promoters and/or enhancers. A number of cellular proteins have been identified as co-regulators to regulate this transactivation process. One common structural feature among these co-regulators is the presence of the LXXLL motif (X, any amino acid), the so-called nuclear receptor (NR) box, through which binding of these regulatory proteins to AR occurs. We have recently shown that Tip110 functions to potentiate the transactivation activity of human immunodeficiency virus type I (HIV-1) Tat protein. In this study, we report that Tip110 is a potent AR-binding protein that can suppress AR activity. Tip110 bound to AR in an NR box-dependent manner and inhibited AREs-mediated reporter gene expression. The inhibitory effects were abolished by removal of the NR box. Moreover, knock-down of the constitutive Tip110 expression significantly augmented AR transcriptional activation. In agreement with these findings, Tip110 overexpression blocked the prostate-specific antigen (PSA) gene, a well characterized target gene of AR from expression in LNCaP cells. Further analysis revealed that Tip110 prevented the complex formation between AR and AREs. Taken together, these results indicate that Tip110 is a negative regulator of AR transcriptional activation, and may be directly involved in AR-related developmental, physiological, and pathological processes.
What Do Prospective Plantings Tell Us About Planted Acreage

Prospective Plantings reports are survey-based estimates of producer planting intentions that are typically released at the end of March and reflect producer responses to the March Agricultural Survey. Good and Irwin (2011) provide a thorough review of the survey procedures used by the USDA. As one of the first indications of the upcoming supply for the new crop year, these reports have been shown to have significant impacts on commodity markets (e.g. Dorfman and Karali, 2015; Xie et al, 2016). However, like any survey-based estimates, Prospective Plantings are subject to sampling and non-sampling errors. While USDA goes to a great extent to minimize potential errors through their survey design and reported data review procedures, some error is unavoidable. The purpose of this article is to assess reliability of Prospective Plantings estimates based on their track record over the last 20 years. In doing so, we are expanding on brief reliability analyses published at the end of each prospective plantings report and taking a more detailed look at the errors associated with these estimates. Several earlier farmdoc daily articles (e.g., April 4, 2014; October 15, 2015; January 27, 2016) examine additional issues related to USDA acreage reports.
Detection of heap management flaws in component-based software

Heap management is responsible for the allocation of heap segments to a running application. When the logic of the heap management is left to the application programmer, as it is the case with programming languages like C and C++, a number of problems may arise. One kind of problems related to imperfect heap management is that of memory leaks, which happen when heap segments become inaccessible before they are deallocated. Closely related to that problem, from the standpoint of programmer's operations, is the problem of corrupted heap due to redundant attempts to deallocate the same heap segment that has been previously allocated. This work presents a method for detecting such flaws in heap management. Our method is based on traces collected during the execution of an application and their off-line analysis in order to determine the presence of memory leaks and redundant deallocations of the same heap segment. When our method is applied to component-based embedded software, it allows to locate the component that had allocated heap memory and did not deallocate it before exiting, as well as the components that are responsible for the redundant deallocation of heap segments.
A review on ADRC based PMSM control designs

Permanent magnet synchronous motor (PMSM) is extensively used in industries. Recently, active disturbance rejection controller (ADRC) based control designs stand out due to advantages for a complex uncertain PMSM servo system. A general design procedure for the ADRC based PMSM control is discussed at the beginning. Then, the ADRC based control designs applied to PMSM servo systems are fully reviewed, in which several aspects are involved: position control, speed control, current control, cascaded ADRC control, and position identification. Moreover, to verify the effectiveness of the ADRC based control, simulations for the PMSM speed control are conducted in the Matlab/Simulink. Conclusions and the future research directions are indicated in the end.
Cost-effective treatment for severely malnourished children: what is the best approach?

UNLABELLED In urban Bangladesh, 437 children with severe malnutrition aged 12-60 months were sequentially allocated to treat either as i) inpatients, ii) day care, or iii) domiciliary care after one week of day care. Average institutional cost (US$) to achieve 80% weight-for-height were respectively $156, $59 and $29/child. As a proportion of the overall costs, staff salaries were the largest component, followed by laboratory tests. Parental costs were highest for domiciliary care, as no food supplements were provided. Nevertheless it was the option most preferred by parents and when the institutional and parental costs were combined, domiciliary care was 1.6 times more cost-effective than day care, and 4.1 times more cost-effective than inpatient care. CONCLUSION With careful training and an efficient referral system, domiciliary care preceded by one week of day care is the most cost-effective treatment option for severe malnutrition in this setting.
Synthesis of High Gain Operational Transconductance Amplifiers for Closed-Loop Operation Using a Generalized Controller-Based Compensation Method

This paper presents a systematic procedure that can be used to create operational transconductance amplifiers (OTAs) for closed-loop operation using multiple low-gain stages to realize extremely high DC gain. Such devices are necessary to realize analog functions with demanding absolute accuracy requirements, e.g., high-resolution ADCs and DACs. The principle is based on the cascade of undamped integrators to realize large DC gains and a state-space derived controller to stabilize its operation in a closed-loop configuration. A programmable OTA fabricated in the IBM 130 nm CMOS process is used as a test vehicle to prove the design principle through its 2 to 5th-order realization. Measured data reveals DC gains ranging from 50 to 150 dB with a 3-dB bandwidth of 10 kHz and a unity gain frequency of 10 MHz. While this paper demonstrates the design principles using CMOS integrated circuits, the principle is general and can be applied to any type of circuit technology in integrated or discrete implementation. Moreover, the methods are easily automated as the principles are based on closed-form formulae as opposed to iterative numerical search techniques.
Pathways and Regulation of Homocysteine Metabolism in Mammals

Two intersecting pathways, the methionine cycle and the transsulfuration sequence, compose the mechanisms for homocysteine metabolism in mammals. The methionine cycle occurs in all tissues and provides for the remethylation of homocysteine, which conserves methionine. In addition, the cycle is essential for the recycling of methyltetrahydrofolate. The synthesis of cystathionine is the first reaction in the irreversible pathway for the catabolism of homocysteine by means of the sequential conversion to cysteine and sulfate. This pathway has a limited distribution and is found primarily in the liver, kidney, small intestine and pancreas. Regulation of homocysteine metabolism is achieved by changes in the quantity of homocysteine distributed between the two competing pathways. Two mechanisms are basic to the regulatory process. Changes in tissue content of the relevant enzymes are the response to sustained perturbations. The inherent kinetic properties of the enzymes provide an immediate response to alterations in the tissue concentrations of substrates and other metabolic effectors. S-adenosylmethionine, S-adenosylhomocysteine, and methyltetrahydrofolate are of particular importance in that context.
Evidence that interleukin‐6 is produced in human skeletal muscle during prolonged running

1 This study was performed to test the hypothesis that inflammatory cytokines are produced in skeletal muscle in response to prolonged intense exercise. Muscle biopsies and blood samples were collected from runners before, immediately after, and 2 h after a marathon race. 2 The concentration of interleukin (IL)‐6 protein in plasma increased from 1.5 ± 0.7 to 94.4 ± 12.6 pg ml−1 immediately post‐exercise and to 22.1 ± 3.8 pg ml−1 2 h post‐exercise. IL‐1 receptor antagonist (IL‐1ra) protein in plasma increased from 123 ± 23 to 2795 ± 551 pg ml−1, and increased further to 4119 ± 527 pg ml−1 2 h post‐exercise. 3 The comparative polymerase chain reaction technique was used to evaluate mRNA for IL‐6, IL‐1ra, IL‐1β and tumour necrosis factor (TNF)‐α in skeletal muscle and blood mononuclear cells (BMNC) (n= 8). Before exercise, mRNA for IL‐6 could not be detected either in muscle or in BMNC, and was only detectable in muscle biopsies (5 out of 8) after exercise. Increased amounts of mRNA for IL‐1ra were found in two muscle biopsies and five BMNC samples, and increased amounts of IL‐1β mRNA were found in one muscle and four BMNC samples after exercise. TNF‐α mRNA was not detected in any samples. 4 This study suggests that exercise‐induced destruction of muscle fibres in skeletal muscles may trigger local production of IL‐6, which stimulates the production of IL‐1ra from circulating BMNC.
A generalized particle model for social coordination and autonomy in MAS

In multi-agent systems (MAS), every autonomous agent tries to increase its own personal utility under complex environment involving a variety of types of social coordination. Modeling the social coordination and autonomy of agents is of great significance for distributed problem-solving in MAS. This paper is devoted to a novel generalized particle approach to model social coordination and autonomy in MAS. At first, we analyze and formalize some typical types of social coordination in MAS. Then we discuss the generalized particle model (GPM) for distributed problem-solving in MAS that is related to social coordination and social dynamics. Finally, we demonstrate the GPM-based parallel algorithm and its properties for parallel distributed task allocation and resource assignment in MAS.
Using the beat histogram for speech rhythm description and language identification

In this paper we present a novel approach for the description of speech rhythm and the extraction of rhythm-related features for automatic language identiﬁcation (LID). Previous methods have extracted speech rhythm through the calculation of features based on salient elements of speech such as consonants, vowels and syllables. We present how an automatic rhythm extraction method borrowed from music information retrieval, the beat histogram, can be adapted for the analysis of speech rhythm by deﬁning the most relevant novelty functions in the speech signal and extracting features describing their periodicities. We have evaluated those features in a rhythm-based LID task for two multilingual speech corpora using support vector machines, including feature selection methods to identify the most informative descriptors. Results suggest that the method is successful in describing speech rhythm and provides LID clas-siﬁcation accuracy comparable to or better than that of other approaches, without the need for a preceding segmentation or annotation of the speech signal. Concerning rhythm typology, the rhythm class hypothesis in its original form seems to be only partly conﬁrmed by our results.
Trends in reported adenocarcinomas of the oesophagus and gastric cardia in Japan

Adenocarcinomas involving the oesophagus and gastric cardia are becoming more common in Western countries, but data from Japan are limited. We sought to determine whether the frequency of these cancers in Japan has increased in recent decades. Review of national cancer mortality data, national registries of oesophageal and gastric cancer cases, and records from two large cancer centres for various time periods between 1950 and 1998 did not show increased reporting of oesophageal adenocarcinomas. In contrast, both national and cancer centre data indicate an absolute increase in the number of gastric cancers involving the C-area (proximal third of the stomach). From a national registry of resected primary gastric cancer cases, those arising in the C-area as a proportion of all tumours rose by 41.8% between 1963 (12.2% of all registered cases) and 1990 (17.3%). Analysis of true cardia (< 2 cm distal to oesophagus–cardia junction) early cancers from the two cancer centres showed significant increases in both absolute number and in proportion to other gastric cancers over a 36-year period. These data suggest that the frequency of cardia cancers is increasing in Japan. Lack of a parallel increase in oesophageal adenocarcinomas could be due to misclassification artefacts and/or coding preferences for gastro–oesophageal junction tumours.
Cutting Edge: IL-12 Inversely Regulates T-bet and Eomesodermin Expression during Pathogen-Induced CD8+ T Cell Differentiation1

Cytokines are critical determinants for specification of lineage-defining transcription factors of CD4+ T cell subsets. Little is known, however, about how cytokines regulate expression of T-bet and eomesodermin (Eomes) in effector and memory CD8+ T cells. We now report that IL-12, a signature of cell-mediated immunity, represses Eomes while positively regulating T-bet in effector CD8+ T cells during infection with Listeria monocytogenes. After resolution of infection and abatement of IL-12 signaling, Eomes expression rises whereas T-bet expression declines in memory CD8+ T cells. Eomes becomes derepressed in effector cells by ablation of IL-12 signaling. In the absence of IL-12, the dynamics of clonal expansion and contraction are also perturbed. Together, these results reveal how a pathogen-associated signal, such as IL-12, could act as a switch, regulating appropriate clonal growth and decline while, in parallel, shaping a unique pattern of fate-determining transcription factors.
Capital Flows in European Union on the Basis of International Investment Position – Selected Aspects

The paper aims at assessing the changes in flows of selected forms of capital under deepening financial integration in the European Union. EU Member States are divided into two groups: members of the euro area and those outside of it. The analysis coincides with the establishing of the EU monetary union and covers the turn and early 21st century. Research method applied in this particular study includes the overview of theoretical concepts, literature review and a comparative statistical analysis based on statistical data. Analyses of selected data revealed significant differences between developed and developing countries when it comes to various forms of net capital and its relation to the GDP based on the International Investment Position. Moreover, we evaluated the International Investment Position of Poland against the backdrop of selected countries of Central and Eastern Europe and the eurozone members.
Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily

The nucleotide sequence of the genome of equine arteritis virus (EAV) was determined from a set of overlapping cDNA clones and was found to contain eight open reading frames (ORFs). ORFs 2 through 7 are expressed from six 3'-coterminal subgenomic mRNAs, which are transcribed from the 3'-terminal quarter of the viral genome. A number of these ORFs are predicted to encode structural EAV proteins. The organization and expression of the 3' part of the EAV genome are remarkably similar to those of coronaviruses and toroviruses. The 5'-terminal three-quarters of the genome contain the putative EAV polymerase gene, which also shares a number of features with the corresponding gene of corona- and toroviruses. The gene contains two large ORFs, ORF1a and ORF1b, with an overlap region of 19 nucleotides. The presence of a "shifty" heptanucleotide sequence in this region and a downstream RNA pseudoknot structure indicate that ORF1b is probably expressed by ribosomal frameshifting. The frameshift-directing potential of the ORF1a/ORF1b overlap region was demonstrated by using a reporter gene. Moreover, the predicted ORF1b product was found to contain four domains which have been identified in the same relative positions in coronavirus and torovirus ORF1b products. The sequences of the EAV and coronavirus ORF1a proteins were found to be much more diverged. The EAV ORF1a product contains a putative trypsinlike serine protease motif. Our data indicate that EAV, presently considered a togavirus, is evolutionarily related to viruses from the coronaviruslike superfamily.
Cytokine gene profile in gastric mucosa in Helicobacter pylori infection and Zollinger-Ellison syndrome

OBJECTIVE:Helicobacter pylori-associated inflammation is mediated, in part, by inflammatory cytokines. In contrast, the mucosal disease associated with Zollinger-Ellison syndrome (ZES) is acid driven, and the role of cytokines is not known. The aim of this study was to elucidate the role of cytokines in these two diseases, as we quantitated proinflammatory cytokine messenger RNA (mRNA) levels in the gastric mucosa from patients with H. pylori infection and ZES.METHODS:The study population included 11 patients with H. pylori infection, 12 with ZES, 17 with both H. pylori infection and ZES, and three control subjects with neither. Using a competitive polymerase chain reaction for interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor-α, the polymerase chain reaction products in gastric biopsies were quantitated by capillary electrophoresis and laser-induced fluorescence.RESULTS:The levels of IL-1β, IL-6, IL-8, and tumor necrosis factor-α mRNA in gastric tissue of patients with H. pylori infection only and ZES only exceeded the levels in the control gastric tissue (p < 0.05 to p < 0.005). Unexpectedly, the number of molecules of IL-1β and IL-8 mRNA in gastric tissue from ZES patients exceeded the levels in gastric tissue from patients with H. pylori only (p < 0.05). The local levels of cytokine mRNA in patients with both diseases exceeded the levels in patients with H. pylori only (IL-6, p < 0.05; IL-8, p < 0.05) and ZES only (IL-6, p < 0.05; tumor necrosis factor-α, p < 0.05). CONCLUSIONS:Levels of proinflammatory cytokine mRNA are increased in acid-driven as well as infection-driven gastric inflammation, and the presence of both disease processes appears to have an additive effect on local cytokine message expression. Inflammatory cytokines may mediate both infection- and acid-driven gastric inflammation.
Ureteral access sheath use and stenting in ureteroscopy: effect on unplanned emergency room visits and cost.

PURPOSE We studied the impact of stented and unstented ureteroscopy on unplanned emergency room (ER) return visits, medical costs, and whether use of a ureteral access sheath precluded uncomplicated ureteroscopy. PATIENT AND METHODS A series of 161 consecutive patients undergoing ureteroscopy for renal or ureteral stones was evaluated retrospectively. We examined sex, age, stone size, stone location, use of a ureteral access sheath, use of a ureteral stent, unplanned ER visits, unplanned imaging, and interventions. Medical costs were calculated according to British Columbia Medical Services Plan rates. RESULTS In the 107 stented and 54 unstented patients, the mean stone sizes were 9 and 7 mm, respectively (P = 0.01), and ureteral access sheaths were used in 55% and 35% (P = 0.002). Stent use did not differ by patient age or sex or stone location. The ER return rates were 17% v 22% for the stented and unstented patients, respectively (P = 0.40), with emergency CT scans being performed in 28% v 75% of the returning patients (P = 0.02), hospital readmission in 22% v 58% (P = 0.05), and urgent decompression in 0 v 25% (P = 0.04). Among patients who were not stented, 37% of those treated using ureteral access sheaths v 14% treated without access sheaths returned to the ER (P = 0.04). The median costs were CDN dollars 1212 for stented and CDN dollars1071 for unstented patients (P < 0.0001). CONCLUSIONS The unplanned ER return rate is similar whether patients are stented or unstented after ureteroscopy. The median cost saving for unstented patients is approximately CDN dollars140. Use of a ureteral access sheath precludes uncomplicated ureteroscopy, and a ureteral stent should be placed in these cases.