Miracle-dz/UniFAR-FTUs huggingface dataset:
Code Compression and Decompression for Coarse-Grain Reconfigurable Architectures

This paper presents a code compression and on-the-fly decompression scheme suitable for coarse-grain reconfigurable technologies. These systems pose further challenges by having an order of magnitude higher memory requirement due to much wider instruction words than typical VLIW/TTA architectures. Current compression schemes are evaluated. A highly efficient and novel dictionary-based lossless compression technique is implemented and compared against a previous implementation for a reconfigurable system. This paper looks at several conflicting design parameters, such as the compression ratio, silicon area, latency, and power consumption. Compression ratios in the range of 0.32 to 0.44 are recorded with the proposed scheme for a given set of test programs. With these test programs, a 60% overall silicon area saving is achieved, even after the decompressor hardware overhead is taken into account. The proposed technique may be applied to any architecture which exhibits common characteristics to the example reconfigurable architecture targeted in this paper.
Extended beta-binomial model for demand forecasting of multiple slow-moving inventory items

This article considers the problem of modelling the lead-time demand for multiple slow-moving inventory items in the case when the available demand history is very short, and a large percentage of items has only zero records. The Bayesian approach is used to overcome these problems with the past demand data: it is proposed to use the beta-binomial model to predict the lead-time demand probability distribution for each item. Further, an extension of this model is developed which incorporates the prior information regarding the maximum expected probability of demand per period. Parameter estimation and Bayesian forecasting routines are derived for the new model. The performance of the proposed techniques is evaluated by a simulation study.
Alterations in glycosylation as biomarkers for cancer detection

Glycoconjugates constitute a major class of biomolecules which include glycoproteins, glycosphingolipids and proteoglycans. Glycans are involved in several physiological and pathological conditions, such as host–pathogen interactions, cell differentiation, migration, tumour invasion and metastisation, cell trafficking and signalling. Cancer is associated with glycosylation alterations in glycoproteins and glycolipids. This review describes various aspects of protein glycosylation with the focus on alterations associated with human cancer. The application of these glycosylation modifications as biomarkers for cancer detection in tumour tissues and serological assays is summarised.
Role of p53 family members in apoptosis

p53‐mediated apoptosis involves multiple mechanisms. A number of p53‐regulated apoptosis‐related genes have been identified. Some of these genes encode proteins that are important in controlling the integrity of mitochondria while the others code for membrane death receptors. p53 may also induce apoptosis by interfering with the growth factor‐mediated survival signals. Although the transactivation‐deficient p53 can induce apoptosis, evidence suggests that both the transcription‐dependent and independent functions are needed for full apoptotic activity. p73 and p63 are two other members of the p53 family that show homology to p53 in their respective transactivation, DNA‐binding and oligomerization domains. Both p73 and p63 transactivate p53‐regulated promoters and induce apoptosis. Evidence suggests that both p73 and p63 may mediate apoptosis via some of the same mechanisms that are utilized by p53. However, both p73 and p63 exhibit features that are different from those of p53. Hence, both p73 and p63 are predicted to mediate apoptosis via mechanisms that are completely distinct from those engaged by p53. J. Cell. Physiol. 182:171–181, 2000. Published 2000 Wiley‐Liss, Inc.
Differential alterations in systemic and regional oxygen delivery and consumption during the early and late stages of sepsis.

BACKGROUND Studies have indicated that regional changes in oxygen utilization during sepsis cannot be predicted from the changes in the whole body oxygen delivery (DO2) and consumption (VO2). The aim of this study, therefore, was to determine whether differential alterations in systemic and regional DO2 and VO2 occur during the early and late stages of sepsis. METHODS Adult male Sprague-Dawley rats were subjected to sepsis by cecal ligation and puncture (CLP). At 5 hours (i.e., the early, hyperdynamic phase of sepsis) or 20 hours (i.e., the late, hypodynamic phase) after CLP, cardiac output, and organ blood flow were measured by radioactive microspheres. Systemic and regional DO2 and VO2 were determined and plasma levels of lactate were measured. RESULTS Cardiac output and blood flow to the liver, small intestine, and kidneys increased at 5 hours and decreased at 20 hours after CLP. Although both systemic DO2 and VO2 increased at 5 hours after CLP, systemic DO2 but not VO2 decreased at 20 hours. At 5 hours after CLP, intestinal and renal DO2 increased. However, DO2 in all the tested organs decreased at 20 hours after CLP. VO2 increased in the liver, small intestine, and kidneys at 5 hours after CLP but decreased only in the liver and small intestine at 20 hours after the onset of sepsis. Moreover, plasma lactate levels increased at the late stage of sepsis. CONCLUSION Because hepatic and intestinal VO2 but not systemic and renal VO2 decreased at 20 hours after CLP, the liver and small intestine seem to be more vulnerable to the hypoxic insult during the hypodynamic stage of polymicrobial sepsis.
Nucleotide sequences of the envelope genes of two isolates of feline leukemia virus subgroup B

We determined the nucleotide sequences of the envelope genes of the Snyder-Theilen and Gardner-Arnstein isolates of feline leukemia virus subgroup B. Comparison of the deduced amino acid sequences of the envelope gene products revealed regions of sequence divergence, which we relate to structural features of the viral protein. We also examined nucleotide sequences within the long terminal repeats of these related isolates of feline leukemia virus subgroup B.
Early vascular damage in primary hypoalphalipoproteinemia.

The relationship between hypoalphalipoproteinemia (hypoalpha), a metabolic disorder characterized by reduced high-density lipoprotein (HDL) cholesterol levels, and atherosclerotic disease is not completely understood. We investigated arterial functional and structural changes in 19 subjects with hypoalpha (HDL cholesterol < or = 0.7 mmol/L for men and < or = 0.8 mmol/L for women; 13 men; 47 +/- 7 years) and in 21 healthy control subjects (11 men; 46 +/- 13 years). Brachial-artery flow-mediated vasodilation (FMV) and intima-media thickness (IMT) of the carotid and femoral arteries were determined in all subjects. FMV was significantly lower in hypoalpha than in controls (5.6% +/- 4.3% v 8.2% +/- 2.7%; P <.05). IMT was greater in hypoalpha than in controls at both the internal carotid (0.83 +/- 0.1 mm v 0.69 +/- 0.1 mm) and superficial femoral level (0.83 +/- 0.2 mm v 0.68 +/- 0.1 mm; both P <.05). FMV had a positive correlation with HDL cholesterol (r =.42, P =.06) and a negative one with triglycerides (r = -0.38, P =.01). An inverse relationship was found between HDL cholesterol and internal carotid and superficial femoral IMT (r = -0.64 and r = -0.60, respectively; P <.01 for both) and a positive one between triglycerides and internal carotid and superficial femoral IMT (r =.53 and r =.47, P <.05). In a multivariate regression analysis, brachial FMV was predicted by HDL cholesterol and brachial diameter (beta =.42 and -0.43, respectively; both P <.05). HDL cholesterol was the only significant predictor of internal carotid and superficial femoral IMT (beta = -0.45 and -0.49, respectively; both P <.05). In conclusion, subjects with primary hypoalpha, without overt cardiovascular disease, are characterized by an impaired endothelial function and by an increase in large-artery IMT.
Healthcare innovation and market forces.

Health services in many developed countries are experiencing an urgent need for innovation in response to an ageing population and the growing prevalence of chronic and degenerative diseases.Many urge reform of what are now perceived as inadequate and outdated services that have traditionally focused on a medical model predicated on access, continuity, integration and comprehensive care. Differentiation is the new mantra, and those committed to patient empowerment and professional role innovation are setting new trends. However, as we consider a fresh approach to health care we reflect on the experience of many researchers whose enthusiasm is tempered by frustration at the limited support for projects at the coal face. At present there are 7361 general practices in Australia and more than 4500 individual pharmacy outlets. Official data, now ten years old, also identified physiotherapists working from 4050 locations in primary care. In this country, remuneration for health services in the community is based on a fee for service, and many consequently argue that ‘time is money’. A general practitioner (GP) made a typical comment in theWeekendAustralianon20–21September 2008:
Virus linfotrópico T-humano tipo 1 y 2 (HTLV-1/2): optimización del diagnóstico y epidemiología molecular en distintas poblaciones de Argentina

El objetivo principal de esta tesis es ampliar los conocimientos sobre el diagnostico, la prevalencia y la epidemiologia molecular del HTLV-1/2 y brindar datos que permitan un diagnostico mas eficiente en Argentina. Con tal fin, se analizaron equipos de tamizaje frecuentemente utilizados en nuestro pais, y se demostro la importancia de confirmar los resultados seroindeterminados por WB mediante una tecnica molecular para obtener un diagnostico final. En cuanto a la prevalencia de HTLV-1/2 en las distintas poblaciones estudiadas, hemos demostrado que ambos virus se encuentran circulando con prevalencias altas en poblaciones de riesgo y bajas en las de no riesgo en la mayor parte del pais, manteniendo la caracteristica epidemiologica de su restriccion etnico/geografica ya demostrada. Es por ello, que debemos considerar tambien el riesgo de infeccion en aquellos casos que presenten antecedentes de riesgo como, por ejemplo, haber nacido, ser descendientes o haber sido pareja sexual de individuos provenientes de areas endemicas. Mediante estudios filogeneticos se demostro que todas las cepas estudiadas del HTLV-1, resultaron subtipo a subgrupo A, mientras que para el HTLV-2 el subtipo b fue el mayoritario ambos en poblaciones no originarias sugiriendo que estos subtipos han sido introducidos en nuestra poblacion caucasica a partir de la interaccion con comunidades originarias.
[Role of endoplasmic reticulum stress in alcoholic liver disease-related hepatocyte apoptosis].

OBJECTIVE To investigate the role of endoplasmic reticulum stress (ERS) in alcoholic liver disease (ALD)-related hepatocyte apoptosis. METHODS A rat model of ALD was established by continuous intragastric administration of ethanol. At 4, 8, 12, and 16 weeks later, randomly selected rats were sacrificed for serum and liver sample collection. Serum levels of total homocysteine (tHcy) were examined by chemiluminescence analysis. Cystathionine beta-synthase (CBS) activity in liver tissue was measured by chromatometry. The mRNA and protein expressions of ERS-related factors, glucose-regulated protein (GRP)-78, calpain 2 and caspase-12, were analyzed by reverse transcription-polymerase chain reaction and immunohistochemistry, respectively. Hepatocyte apoptosis was detected by the TdT-mediated dUTP nick end labeling assay. RESULTS At 16 weeks, the ALD rats' livers exhibited diffuse microvesicular adipose degeneration and fibrosis in the liver sinus and portal septa. As the duration of ethanol administration extended, the tHcy levels gradually increased (P less than 0.01), CBS activity decreased (P less than 0.01), gene expression levels of GRP-78, calpain 2, and caspase-12 were up-regulated (P less than 0.01), and protein expression levels of GRP-78 and calpain 2 were gradually increased. However, the protein level of procaspase-12 was found to decrease with increased duration of ethanol administration. Finally, the hepatocyte apoptosis index showed an increasing trend over time (P less than 0.01). CONCLUSION In our experimental ALD rat model, hepatic apoptosis was detected with increasing frequency over the duration of ALD. Increased apoptosis was likely due to decreased CBS activity causing hyperhomocysteinemia, which further induced ERS and activated the calpain 2 and caspase-12 signaling pathway. These ethanol-induced molecular changes may provoke hepatic apoptosis and subsequently promote the pathogenic processes of alcoholic liver disease.
Influence of N-Linked Glycosylation of Porcine Reproductive and Respiratory Syndrome Virus GP5 on Virus Infectivity, Antigenicity, and Ability To Induce Neutralizing Antibodies

ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) glycoprotein 5 (GP5) is the most abundant envelope glycoprotein and a major inducer of neutralizing antibodies in vivo. Three putative N-linked glycosylation sites (N34, N44, and N51) are located on the GP5 ectodomain, where a major neutralization epitope also exists. To determine which of these putative sites are used for glycosylation and the role of the glycan moieties in the neutralizing antibody response, we generated a panel of GP5 mutants containing amino acid substitutions at these sites. Biochemical studies with expressed wild-type (wt) and mutant proteins revealed that the mature GP5 contains high-mannose-type sugar moieties at all three sites. These mutations were subsequently incorporated into a full-length cDNA clone. Our data demonstrate that mutations involving residue N44 did not result in infectious progeny production, indicating that N44 is the most critical amino acid residue for infectivity. Viruses carrying mutations at N34, N51, and N34/51 grew to lower titers than the wt PRRSV. In serum neutralization assays, the mutant viruses exhibited enhanced sensitivity to neutralization by wt PRRSV-specific antibodies. Furthermore, inoculation of pigs with the mutant viruses induced significantly higher levels of neutralizing antibodies against the mutant as well as the wt PRRSV, suggesting that the loss of glycan residues in the ectodomain of GP5 enhances both the sensitivity of these viruses to in vitro neutralization and the immunogenicity of the nearby neutralization epitope. These results should have great significance for development of PRRSV vaccines of enhanced protective efficacy.
Acute liver failure in pregnancy. A case report.

BACKGROUND Liver disease in pregnancy can be grossly divided into those disorders coincidentally occurring during the pregnant state and hepatic diseases limited to pregnancy. Numerous infectious agents can result in acute hepatitis and include not only the hepatitis viruses--A, B, C and E--but herpesvirus and cytomegalovirus as well. Coxsackie B viruses can cause several clinical presentations, ranging from asymptomatic to mild febrile illness to myocarditis and meningitis. Rarely has coxsackievirus infection been associated with fulminant hepatic failure. CASE A Coxsackie B virus infection resulted in acute liver failure in a gravid woman. The patient was managed expectantly, with resolution of the liver disease and delivery five weeks after discharge. CONCLUSION The onset of hepatic disease is insidious, with only vague symptoms or minor complaints often heralding the progression to liver failure. A careful history, physical examination and appropriate diagnostic tests can help determine the etiology of hepatic disease and help decide whether expectant management of the gravid patient or immediate delivery is appropriate.
Immunological Issues in Clinical Composite Tissue Allotransplantation: Where Do We Stand Today?

Composite tissue allografts are made of histogenetically different tissues and although skin seems to be the most antigenic of them, it is unknown whether the dominant immune response is really directed against the skin or we have insufficient information on the involvement of the other components of these allografts. The first clinical signs of acute rejection manifest on the skin and microscopically the earliest lesions consist in a dermal perivascular lymphocytic infiltrate, predominantly made of CD3+/CD4+ T cells. On the basis of the histological changes, a specific score (Banff score 2007) has been established to assess the severity of rejection. Despite the high incidence of acute rejection episodes, they can be completely reversed when promptly diagnosed and treated. C4d deposits in the skin and circulating donor-specific antibodies are rarely detected, suggesting that humoral rejection does not play a significant role in composite tissue allotransplantation. Chronic rejection features are still unknown. The majority of recipients have been maintained on an immunosuppressive regimen consisting of tacrolimus, steroids, and mycophenolate mofetil. The complications in composite tissue allotransplantation are similar to those usually reported after solid organ transplantation and have prompted different strategies to minimize the maintenance immunosuppression or to induce donor-specific tolerance. Furthermore, to what extent the immunosuppression can be tapered is unknown, as well as the influence of donor bone-marrow infusion in tolerance and chronic rejection. The increasing number of patients and the longer follow-up hopefully will allow answering these questions.
A Multi-Class Proportional Myocontrol Algorithm for Upper Limb Prosthesis Control: Validation in Real-Life Scenarios on Amputees

Functional replacement of upper limbs by means of dexterous prosthetic devices remains a technological challenge. While the mechanical design of prosthetic hands has advanced rapidly, the human-machine interfacing and the control strategies needed for the activation of multiple degrees of freedom are not reliable enough for restoring hand function successfully. Machine learning methods capable of inferring the user intent from EMG signals generated by the activation of the remnant muscles are regarded as a promising solution to this problem. However, the lack of robustness of the current methods impedes their routine clinical application. In this study, we propose a novel algorithm for controlling multiple degrees of freedom sequentially, inherently proportionally and with high robustness, allowing a good level of prosthetic hand function. The control algorithm is based on the spatial linear combinations of amplitude-related EMG signal features. The weighting coefficients in this combination are derived from the optimization criterion of the common spatial patterns filters which allow for maximal discriminability between movements. An important component of the study is the validation of the method which was performed on both able-bodied and amputee subjects who used physical prostheses with customized sockets and performed three standardized functional tests mimicking daily-life activities of varying difficulty. Moreover, the new method was compared in the same conditions with one clinical/industrial and one academic state-of-the-art method. The novel algorithm outperformed significantly the state-of-the-art techniques in both subject groups for tests that required the activation of more than one degree of freedom. Because of the evaluation in real time control on both able-bodied subjects and final users (amputees) wearing physical prostheses, the results obtained allow for the direct extrapolation of the benefits of the proposed method for the end users. In conclusion, the method proposed and validated in real-life use scenarios, allows the practical usability of multifunctional hand prostheses in an intuitive way, with significant advantages with respect to previous systems.
A Decision Feedback Equalizer with Time-Reversal Structure

This work describes the use of a receiver with a time-reversal structure for low-complexity decision feedback equalization of slowly fading dispersive indoor radio channels. Time-reversal is done by storing each block of received signal samples in a buffer and reversing the sequential order of the signal samples in time prior to equalization. As a result, the equivalent channel impulse response as seen by the equalizer is a time-reverse of the actual channel impulse response. Selective time-reversal operation, therefore, allows a decision feedback equalizer (DFE) with a small number of forward filter taps to perform equally well for both minimum-phase and maximum-phase channel characteristics. The author evaluates the theoretical performance bounds for such a receiver and quantifies the possible performance improvement for discrete multipath channels with Rayleigh fading statistics. Two extreme cases of DFE examples are considered: an infinite-length DFE; and a DFE with a single forward filter tap. Optimum burst and symbol timing recovery is addressed and several practical schemes are suggested. Simulation results are presented. The combined use of equalization and diversity reception is considered. >
Automatic tissue classification for high-resolution breast CT images based on bilateral filtering

Breast tissue classification can provide quantitative measurements of breast composition, density and tissue distribution for diagnosis and identification of high-risk patients. In this study, we present an automatic classification method to classify high-resolution dedicated breast CT images. The breast is classified into skin, fat and glandular tissue. First, we use a multiscale bilateral filter to reduce noise and at the same time keep edges on the images. As skin and glandular tissue have similar CT values in breast CT images, we use morphologic operations to get the mask of the skin based on information of its position. Second, we use a modified fuzzy C-mean classification method twice, one for the skin and the other for the fatty and glandular tissue. We compared our classified results with manually segmentation results and used Dice overlap ratios to evaluate our classification method. We also tested our method using added noise in the images. The overlap ratios for glandular tissue were above 94.7% for data from five patients. Evaluation results showed that our method is robust and accurate.
Intensive Care Managament of Acute Organophosphate Poisoning : Clinical Experience and the Review of the Literature

Current therapeutic scheme for management of acute poisoning with anticholinesterase pesticides includes general supportive measures (decontamination, respiratory support) and specific pharmacological treatment (atropine, oxime, diazepam). Antidote therapy is aimed to competitively antagonise overstimulation of muscarinic receptors with atropine and to reactivate inhibited AChE with oximes. Rectivation and clinical improvement of neuromuscular function are limited by aging of acetylcholinesterase and high concentrations of organophosphates. Results of our longitudinal clinical experience confirm benefitial effect of oxime administration in OP poisoning.