Miracle-dz/UniFAR-FTUs huggingface dataset:
Multilevel analysis of nuclear dynamics in lamin perturbed fibroblasts

The nuclear lamina provides structural support to the nucleus and has a central role in defining nuclear organization. Defects in its filamentous constituents, the lamins, lead to a class of diseases collectively referred to as laminopathies. On the cellular level, lamin mutations affect the physical integrity of nuclei and nucleo-cytoskeletal interactions, resulting in increased susceptibility to mechanical stress and altered gene expression [1]. Most studies regarding the mechanical properties of the nucleus in laminopathic conditions are based on the induction of extracellular stress, such as strain or compression, and focus on nuclear integrity and/or nucleo-cytoskeletal interaction [2]. Far less is known about the role of nuclear organization and mobility under basal steady-state conditions. In this study, we quantitatively compared nuclear organization, nuclear deformation and chromatin mobility of fibroblasts from a Hutchinson-Gilford progeria patient with cells from a lamin A/C-deficient patient and wild-type dermal fibroblasts. To this end, we created a toolbox in imageJ for automatically analyzing both nuclear as well as subnuclear dynamics in living cells. Simultaneously, we developed a workflow for comparing cellular morphology and subcellular protein distribution in a high content fashion. We found that the absence of functional lamin A/C leads to increased nuclear plasticity on the hour and minute time scale but also to increased intranuclear mobility down to the seconds time scale. In contrast, progeria cells showed overall reduced nuclear dynamics. In addition, high content analysis revealed marked morphological and topological differences between different culture passages within a cell type and between different pathological variants of culture-age matched laminopathic cell types.
Doubts on input quality: The effect of inaccurate fertilizer content on the estimation of production functions and technical efficiency

Household survey responses regarding levels of input use are sometimes affected by bias of which even the households themselves are not aware. Some examples include poor quality seed with a mixture of the fertile and infertile types, and pesticide content that has been substituted with less effective chemicals. We analyze in our paper the effect of low quality fertilizer, which contains less nitrogen than is advertised on the packaging. We show that this could lead to bias in the estimation of marginal effect and technical efficiency. Using panel data from the Hebei province of China, we calculate the magnitude of the bias across different levels of fertilizer quality. We find that the bias could be between -2% and -7% for marginal effect of fertilizer at mean input levels, and between 1% and 4% for technical efficiency.
The influence of a sweat rate on heat losses of the selected segments of a sweating thermal manikin

Abstract The procedure of determining the heat resistance, i.e. thermal insulation is described in a series of the European Standards. It is well recognised and disseminated across the world. However, there is no European Standard with regard to the procedure for determining clothing evapourative resistance (Ret). In 2016, ASTM published F2370 standard where it set out the method for determining Ret. The said standard however is lacking detailed information concerning the required sweat rate for a manikin. The aim of the present study was to examine the influence of a sweat rate on the segmental heat losses at the selected manikin’s parts in the so-called isothermal and non-isothermal conditions. The research was carried out on the NEWTON thermal manikin dressed in special fabric skin. Four sweating rates were considered, i.e. 100, 250, 500 and 650 g/(h m2). The results showed different segmental heat loss in isothermal and non-isothermal conditions. It was furthermore found that heat loss depended on a sweat rate, namely a lower sweat rate caused lower heat loss.
Possibility of using ribs to protect pipelines from the long crack propagation

This research aims to build a finite element model of oil or gas steel pipelines transmission. The model has been developed in that crack propagation in pipes can be reduced as possible to avoid the failure. The suggestion that is taken into consideration for this purposeis to stopping crack propagation as possibly, is by using ribs as arresters. Different thicknesses have been tested for the ribs used in this study. The first one was of 0.02 m, while as the second thickness was of 0.05 m. The dimensions of pipe are of 0.01 m thickness, and diameter of 0.5 m. The model of pipe consists of three parts. The first part has two different lengths 2 m and 3 m. The second, which is the rib, is of length of 0.15 m. The third part of pipe has the length of 1 m. So all the three parts are made up the case study that was studied in this work. The value of stress intensity factor K1 for different lengths of cracks has been calculated by the finite element model deve-loped by using ANSYS package. These calculations were applied with and without ribs. The results showed that when using the ribs, the stress intensity factor would be reduced significantly. This leads to reduce the possibility of failure.
Strategy without ontology

Professor Arend's critique raises fundamental epistemological issues for strategy research, particularly the concern that pragmatist philosophy forecloses access to objective truth and scientific progress. This response discusses the empiricist underpinnings of pragmatism, and addresses Professor Arend's specific concerns about the connections between competitive advantages and firm performance.
Perceptions of Family Environment of Boys with Attention Deficit Hyperactivity Disorder and Their Mothers

Children with Attention Deficit Hyperactivity Disorder (ADHD) experience a significant number of psychological symptoms and behavioral problems which negatively affect their interactions within their families. The purpose of the present study was to explore the perceptions of family environment of boys with ADHD and their mothers and compare them to those of nonreferred boys and their mothers. Maternal reports of emotional distress and perceptions of hyperactive behavior in the two groups of boys were also studied.
Energy-restricted diet during lactation programs ovarian growth factors and gonadotropins receptors expression in rats. Lactation diet and ovary programming

The goal of this study was to evaluate whether a maternal energy-restricted diet could program ovarian angiogenesis, growth factors and gonadotropins receptors expression in rats. After parturition, six Wistar rats with 6 pups each were randomly assigned to one of the following groups: control group (C), with free access to a standard laboratory diet containing 23% protein; and an energy-restricted group (ER), receiving 60% of the amount consumed by the control group. After weaning, all the female pups had free access to the standard laboratory diet until 90 days of age, when they were killed during the proestrus stage. Blood was collected for further evaluation of serum estradiol levels. One ovary was stored -80oC for RT-PCR analysis while the other one was paraffin embedded, sectioned at 5-µm thickness and processed by routine histological analyses for evaluation of vessels density. All results are shown as mean ± SEM. Statistical analysis was performed by Student’s t-test. P < 0.05 was considered statistically significant The ER group presented a reduction in the follicle stimulating hormone (C = 2.36 ± 0.21, ER = 0.97 ± 0.15, P < 0.001) and luteinizing hormone (C = 1.81 ± 0.11, ER = 0.74 ± 0.11, P < 0.0004) receptors expression. This group also presented an increase in the gene expression of basic fibroblast growth (C = 0.51 ± 0.07, ER = 0.72 ± 0.06, P < 0.04) and vascular endothelial growth factors (C = 0.82 ± 0.03, ER = 1.06 ± 0.08, P < 0.02). Estradiol serum concentration, the vessel density, the kinase-insert domain receptor, Fms-like tyrosine kinase-1 and fibroblast growth factor receptor-1 gene expressions were unchanged. The results indicated that energy maternal energy-restricted diet during lactation programs the ovarian response to FSH, LH and the angiogenic factors.
The 100-month Swift catalogue of supergiant fast X-ray transients ⋆ I. BAT on-board and transient monitor flares ⋆⋆

Context. Supergiant fast X-ray transients (SFXTs) are high mass X-ray binaries (HMXBs) that are defined by their hard X-ray flaring behaviour. During these flares they reach peak luminosities of 10 36 ‐10 37 erg s −1 for a few hours (in the hard X-ray), which are much shorter timescales than those characterizing Be/X-ray binaries. Aims. We investigate the characteristics of bright flares (detections in excess of 5σ) for a sample of SFXTs and their relation to the orbital phase. Methods. We have retrieved all Swift/BAT Transient Monitor light curves and collected all detections in excess of 5σ from both dailyand orbital-averaged light curves in the time range of 2005 February 12 to 2013 May 31 (MJD 53413‐56443). We also considered all on-board detections as recorded in the same time span and selected those in excess of 5σ and within 4 arcmin of each source in our sample. Results. We present a catalogue of over a thousand BAT flares from 11 SFXTs, down to 15‐150 keV fluxes of ∼6 ×10 −10 ergcm −2 s −1 (daily timescale) and ∼1.5 ×10 −9 ergcm −2 s −1 (orbital timescale, averaging ∼800 s); the great majority of these flares are unpublished. The catalogue spans 100 months. This population is characterized by short (a few hundred seconds) and relatively bright (in excess of 100 mCrab, 15‐50 keV) events. In the hard X-ray, these flares last generally much less than a day. Clustering of hard X-ray flares can be used to indirectly measure the length of an outburst, even when the low-level emission is not detected. We construct the distributions of flares, of their significance (in terms of σ), and of their flux as a function of orbital phase to infer the properties of these binary systems. In particular, we observe a trend of clustering of flares at some phases as Porb increases, which is consistent with a progression from tight circular or mildly eccentric orbits at short periods to wider and more eccentric orbits at longer orbital periods. Finally, we estimate the expected number of flares for a given source for our limiting flux and provide the recipe for calculating them for the limiting flux of future hard X-ray observatories.
A Study about Fe-Ni Mechanical Alloying Process by Dry and Wet Method

The evolutions of microstructure of Fe0.85Ni0. 15 products, which were prepared by mechanical alloying (MA) with and without process control agent (PCA), were studied using X-ray diffraction and scanning electron microscopy respectively. After MA without PCA (dry method) for 30h, Fe0.85Ni0. 15 nanocrystalline alloy powders with bcc-Fe(Ni) phase were obtained; however, powders milled with PCA (wet method) from 20 to 90 h, were unalloyed Fe-Ni mixtures with balanced morphology. It seems that dry method works efficiently in nanocrystalline alloying while wet method postpones MA but functionally fines the morphology of materials. Finally, the results were discussed
Proliferation of Mycorrhizal Fungal Species on Organic Matter Improves Nitrogen Nutrition in Russian Wildrye

Arbuscular mycorrhizal fungi (AMF) facilitate plant growth by aiding nutrient movement to plants especially under low fertility conditions. Arbuscular mycorrhizal fungi generally takes N as NH4 + or NO3 - . We hypothesized that AMF enhance soil organic matter decomposition through their stimulating influence on soil microorganisms and help in the transport of nitrogen to plants. Hyphal chambers (HC) containing labelled 15 N organic matter (wheat root and shoot) were inserted in pots. Russian wild rye was inoculated or not with three AM fungal species (G. intraradices, G. claroideum, G. clarum) and was grown for six months. The amount of total C retained in the HC was lower in the presence of AMF hyphae as compared to control and substrate C:N ratio was lower indicating that decomposition was faster in AMF colonized systems. The faster rate of decomposition in HC in presence of AMF was concurrent with change in microbial community structure. Higher N uptake and greater plant biomass were measured in AMF treated Russian wildrye as compared to control. Results of the present investigation suggest that presence of AMF hastens organic matter decomposition, thus enhancing soil N fertility and plant growth.
Effect of Compensation and Career Development on Turnover Intention: Job Satisfaction as a Mediation Variable

Although considerable research report has been devoted to understanding work attitudes, behaviors and outcomes regarding turnover intentions, little has been done to explore it across deferent professions. This study takes a step in this direction and examines the effect of compensation and career development on employee turnover intention: work satisfaction as a mediation variable. Some previous research shows that compensation and career development have a positive and significant influence on job satisfaction. Furthermore, compensation, career development and job satisfaction all together have a significant and negative influence on turnover intention.
FOREX AND THE LIBERALIZED FINANCIAL MARKET

Lucrarea incearcă să prezinte inţelesul, metoda si mecanismul pieţei Forex, precum si riscurile si oportunităţile participanţilor la acest fel de tranzacţii. Autorii prezintă, pe scurt, rolul liberalizării continue a pieţei financiare in contextul cresterii economice globale, precum si principalele caracteristici ale tranzacţiilor internaţionale libere de capital. The present paper is trying to introduce the meaning, method and mechanism of Forex market, as well as the participant’s risks and opportunities in this sort of transactions. The authors also briefly present the role of the continuously liberalizing financial market into the environment of the global economic growth, as well as major concerns about the free capital international transactions.
Evaluation of Consumer-Grade EEG Headsets for BCI Drone Control

—Brain-computer interface (BCI) allows people to control a computer system using their brain signals. The recent availability of consumer-grade electroencephalography (EEG) headsets enables this technology to be used outside the lab. In particular, there has been interest in controlling a drone using brain signals. We propose a system that allows users to manipulate the thrust of the drone using consumer-grade EEG headsets. Active concentration, represented by EEG band powers, was investigated as an input modality for the BCI system. Comparisons were also made between different approaches in data retrieval and processing, as well as headsets. It was found that using supervised learning with SVM and the Muse headset resulted in better performance (around 70%). Ofﬂine evaluation shows that while both Emotiv Insight and Muse had comparable accuracy, Muse had better usability and was thus adopted in our system. Online user testing with the implemented BCI system revealed variable performance across subjects. This highlights the need for incremental training of both classiﬁer and users for improved efﬁcacy.
Supplementary material accompanying "Factoring lexical and phonetic phylogenetic characters from word lists"

Computational historical linguistics is a young and new field. Among it’s major challenge is the collection and preparation of suitable data resources. Here we present an approach that takes lexical data taken from a large collection of publicly available wordlists as input and infers automatic assessments regarding the cognacy of words and sounds. We illustrate the workflow and test it by comparing the results obtained from the computation of Maximum Likelihood trees with those provided by experts. The results show that our workflow still lags behind simpler approaches which analyze the data within a distance-based framework. However, since distance-based analyses bear a blackbox character, not allowing for a rigorous check of the individual decisions which lead to a certain classification proposal, we think that our experiments are an important contribution towards the establishment of more transparent methods in quantitative historical linguistics.
BER Modeling for Interference Canceling Adaptive NLMS Equalizer

Adaptive LMS equalizers are widely used in digital communication systems for their simplicity in implementation. Conventional adaptive filtering theory suggests the upper bound of the performance of such equalizer is determined by the performance of a Wiener filter of the same structure. However, in the presence of a narrowband interferer the performance of the LMS equalizer is better than that of its Wiener counterpart. This phenomenon, termed a non-Wiener effect, has been observed before and substantial work has been done in explaining the underlying reasons. In this work, we focus on the Bit Error Rate (BER) performance of LMS equalizers. At first a model – the Gaussian Mixture (GM) model – is presented to estimate the BER performance of a Wiener filter operating in an environment dominated by a narrowband interferer. Simulation results show that the model predicts BER accurately for a wide range of SNR, ISR, and equalizer length. Next, a model similar to GM termed the Gaussian Mixture using Steady State Weights (GMSSW) model is proposed to model the BER behavior of the adaptive NLMS equalizer. Simulation results show unsatisfactory performance of the model. A detailed discussion is presented that points out the limitations of the GMSSW model, thereby providing some insight into the nonWiener behavior of (N)LMS equalizers. An improved model, the Gaussian with Mean Square Error (GMSE), is then proposed. Simulation results show that the GMSE model is able to model the non-Wiener characteristics of the NLMS equalizer when the normalized step size is between 0 and 0.4. A brief discussion is provided on why the model is inaccurate for larger step sizes.
A Study of Distinctive Localization and Navigation Methods for Mobile Robots

Localization and routing of mobile robots is a wide area, covering a vast range of diverse innovations and applications. It draws consideration on some extremely antiquated strategies, and also probably the most praiseworthy space science and designing. This review paper examines about distinctive localization and navigation approaches which are utilized as a part of service robotics technology. The target is to perform indoor localization proficiently and in the same time make the expense of the prototype as low as could be expected under the circumstances to make it marketed. The target is to plan a less expensive model which will be utilized for home security. We are headed in discovering a best conceivable answer for this issue. This paper draws together, and expands upon, a considerable measure of what have been carried out in robotics community. We have displayed advantages and disadvantages of renowned procedures so it can open entryways for discovering a fresh out of the box new answer for this problem.
The auto assist bar system for disabled people

This paper presents the development of the auto assist bar system to help the disabled people especially paralyzed in the legs where they have a problem to doing transaction stand-to-sit and sit-to-stand. An example the difficult movement of people with disabilities are from wheelchair to bed or from wheelchair to the toilet bowl. Many people with disabilities use the grab bars or assist bar are sold in the markets where it is too difficult and require a lot of energy to use which can cause them to fall and injured. Through this system, the disabled people can do the transaction stand-to-sit and sit-to-stand without assistance from other persons. The work will be performed during this project is testing performance of the sensors, design for the entire system either on mechanical parts and use the PID controller by using Arduino to control of dc motor. PID parameter values of Kp, Ki and Kd is obtained which is suitable to enable a dc motor rotates smoothly. The overall results obtained from this project found all managed to achieve the overall objectives of the system where the system is able to support people with disabilities to stand up and sit down.
Project portfolio management for product innovation

Purpose – The purpose of this paper is to create a benchmark and identify best practices for Project Portfolio Management (PPM) for both tangible product‐based and service product‐based development project portfolios.Design/methodology/approach – A questionnaire was developed to gather data to compare the PPM methods used, PPM performance, PPM challenges, and resulting new product success measures in 60 Australian organisations in a diverse range of service and manufacturing industries.Findings – The paper finds that PPM practices are shown to be very similar for service product development project portfolios and tangible product development project portfolios. New product success rates show strong correlation with measures of PPM performance and the use of some PPM methods is correlated with specific PPM performance outcomes.Research limitations/implications – The findings in this paper are based on a survey of a diverse sample of 60 Australian organisations. The results are strengthened by comparisons w.
Bayesian One-Sided Hypothesis Testing for Shape Parameter in Inverse Gaussian Distribution

This article deals with the one-sided hypothesis testing problem in inverse Gaussian distribution. We propose Bayesian hypothesis testing procedures for the one-sided hypotheses of the shape parameter under the noninformative prior. The noninformative prior is usually improper which yields a calibration problem that makes the Bayes factor to be defined up to a multiplicative constant. So we propose the objective Bayesian hypothesis testing procedures based on the fractional Bayes factor, the median intrinsic Bayes factor and the encompassing intrinsic Bayes factor under the reference prior. Simulation study and a real data example are provided.
Tactical and Information Internet Skills of Students in Secondary School: An Achievement Test

This study which focuses on the Tactical and Information Internet Skills of Yemen's secondary students in Malaysia was carried out in an achievement test. Participating students were requested to complete homeworks and some tasks on the internet. The results showed that the levels of both information and tactical (planning) skills of internet reflect much scope for improvement. Some of the variables (essentials) that affected these skills, education level were most significant and important, while the internet experience years and the total number of hours which they spent online per week did not have any influence. Between the most significant skills and specific information related to obstacles which the secondary students experienced were factors such as determining appropriate search queries, assessing the information located, keeping focus, or using the proper steps to arrive the final purpose. In general, the school students’ achievement calls into questions the extent of possession of adequate levels of tactical skills and information for utilizing the internet for assignments, academic projects or school projects.