Miracle-dz/UniFAR-FTUs huggingface dataset:
Segregation distortion of the CTG repeats at the myotonic dystrophy (DM) locus: new data from Brazilian DM families.

1 de la Cruz F, Shifrin H, Elias S, et al. Prenatal diagnosis by use of fetal cells isolated from maternal blood. Am Obstet Gynecol 1995;173: 1354-5. 2 Adinolfi M. Nonor minimally invasive prenatal diagnostic tests on maternal blood samples or transcervical cells. Prenat Diagn 1995;15:88996. 3 Ganshirt D, Garritsen HSP, Holzgreve W. Fetal cells in maternal blood. Curr Opin Obstet Gynecol 1995;7:103-8. 4 Hengstschlager M, Wawra E. Cytofluorometric assay for the determination of thymidine uptake and phosphorylation in living cells. Cytometry 1993;14:39-45. 5 Hengstschlager M, Wawra E. Cytofluorometric determination of thymidine kinase activity in a mixture of normal and neoplastic cells. Br Cancer 1993;67:1022-5. 6 Hengstschlager M, Hengstschlager-Ottnad E, Pusch 0, Wawra E. The role of p16 in the E2F-dependent thymidine kinase regulation. Oncogene 1996;12:1635-43. 7 Hengstschlager M, Pusch 0, HengstschlagerOttnad E, Ambros PF, Bernaschek G, Wawra E. Loss of the p16/MTSl tumor suppressor gene causes E2F-mediated deregulation of essential enzymes of the DNA precursor metabolism. DNA Cell Biol 1996;15:41-5 1. 8 Hengstschlager M, Pfeilstocker M, Wawra E. Identification of leukemic cells in bone marrow and blood samples by a new cytofluorometric
Reputation and Legitimacy: A Comparative View of Three Municipal Enterprises in Finland

The aim of this study is to map the principal reputation risks and threats to legitimacy in the processes of organisational change among the three cases in question. The key focus is on the core aims and dilemmas associated with transformation into a municipal enterprise form. According to the results, isomorphic forces affect the institutional process in enhancing and diminishing the isomorphism, and in simultaneously creating dilemmas that pose a risk to the organisation’s reputation and threaten its legitimacy. The findings further highlight the need to investigate strategic dilemma management as a tool for controlling reputation risks and legitimacy in the management of change in the public-healthcare sector. Reputation and Legitimacy: A Comparative View of Three Municipal Enterprises in Finland
Characterizing “Adversity” of Pathology Findings in Nonclinical Toxicity Studies

The identification of adverse health effects has a central role in the development and risk/safety assessment of chemical entities and pharmaceuticals. There is currently a need for better alignment regarding how nonclinical adversity is determined and characterized. The European Society of Toxicologic Pathology (ESTP) therefore coordinated a workshop to review available definitions of adversity, weigh determining and qualifying factors of adversity based on case examples, and recommend a practical approach to define and characterize adversity in toxicology reports, to serve as a valuable prerequisite for future organ- or lesion-specific workshops planned by the ESTP.
Cooperative Traffic Control With Green Wave Coordination for Multiple Intersections Based on the Internet of Vehicles

Traffic congestion is a critical concern in most cities. Inefficient traffic control wastes time and fuel, and causes harmful carbon emissions, road accidents, and many economic problems. This paper proposes a cooperative traffic control framework for optimizing the global throughput and travel time for multiple intersections. Adjacent intersections are considered in analyzing their joint passing rates and attempting to maximize the number of vehicles traveling through a road network. The proposed framework provides fairness for each road segment and realizes the green wave concept for arterial roads. This paper extends previous studies by considering the passing rates of continuous road segments and coordinating traffic signals of multiple intersections. The simulation results show that the approach outperforms existing schemes in that it achieves a high global throughput, reduces the average waiting time, lowers the total travel time, and decreases average CO2 emissions. To verify the feasibility of the proposed framework, a wireless access in vehicular environments/dedicated short-range communications-based prototype for lane-level dynamic traffic control is designed and implemented.
Chemotaxis in bacteria.

Bacterial chemotaxis, the movement of motile bacteria toward or away from chemicals, was discovered nearly a century ago by Engelmann (43) and Pfeffer (70, 71). The subject was actively studied for about fifty years, but then there were very few reports until quite recently. For reviews of the literature up to about 1960, see Berg (23) , Weibull (90) and Ziegler (92). The present review will restrict itself to the recent work on chemotaxis in Escherichia coli and Salmonella typhimurium, some of which is also covered in Berg’s review (23).
Analysis of the Excitation, Interaction, and Detection of Bulk and Surface Acoustic Waves on Piezoelectric Substrates

An analytical solution describing the excitation and de- tection of both bulk and surface acoustic waves in piezoelectric media is presented. In particular, the theory is capable of treating those orientations in which propagating bulk and surface wave ve- locities are in close proximity. It is shown that under such condi- tions, the well-known parameter Au/v is no longer a valid measure of the coupling coefficient for the surface wave. Closed form expres- sions are derived for the transducer radiation resistance, surface po- tential, and insertion loss in terms of the transducer geometry and only four substrate parameters, the bulk wave cutoff velocity, the free and metallized surface SAW or pseudo SAW velocities and the off-resonance dielectric constant. The theory is extended to include the effect of an isotropic nonconductive layer over the transducer surface and compari- son is made with experimental measurements on rotated Y-cut quartz.
Antipyretic and analgesic activities of Caesalpinia bonducella seed kernel extract

Ethanolic extract (70%) of Caesalpinia bonducella seed kernel has been subjected for its antipyretic and antinociceptive activities in adult albino rats or mice of either sex at 30, 100 and 300 mg/kg orally. The extract demonstrated marked antipyretic activity against Brewer's yeast‐induced pyrexia in rats. The extract had significant central analgesic activity in hot plate and tail flick methods. It also exhibited marked peripheral analgesic effect in both acetic acid‐induced writhing test in mice and Randall‐Selitto assay in rats. It also significantly inhibited the formalin‐induced hind paw licking in mice. In conclusion, the present study suggests that the ethanolic extract of Caesalpinia bonducella seed kernel possesses potent antipyretic and antinociceptive activities and thus, validates its use in the treatment of pain and pyretic disorders. Copyright © 2005 John Wiley & Sons, Ltd.
Global Current Account Adjustment: A Decomposition

The rising current account deficit in the USA has attracted considerable attention in recent years. We use the "business cycle accounting" methodology to identify the principal distortions that have affected the external accounts of the US. In particular, we measure distortions in the optimality conditions of a simple two-country general equilibrium model using data from the US and the other G7 countries. We then feed these measured distortions into the model individually and use the simulated counterfactual paths of the current account to determine the contribution of each of these "wedges" to the overall external imbalance of the USA. We find that no single wedge in isolation can account closely for the observed current account. However, a combination of productivity differences and deviations from risk-sharing between the US and the rest of the G7 does the best job in accounting for most of the measured movement of the US current account.
A simple and useful three-port converter for integrating renewable energy sources in stand-alone systems

A simple and useful three-port converter is proposed in this paper, which is suitable for integrating renewable energy sources in off-grid applications with low to medium power. It mainly consists of a coupled inductor and two active switches. Isolation between the two renewable energy sources is achieved. Only one active switch functions in either loading mode or battery-charge mode. Hence the switching losses is reduced. Output diode of the proposed converter is removable from the system if one of the power source is integrated inside with anti-reversed-current diode, so that the system overall cost is reduced. Easy control techniques can be applied to the converter, since power decoupling control is not necessary due to the limited power provided by a single PV panel. A 110W experimental prototype with two inputs (30V, 24V) and 80V output, was built and tested under loading mode and battery-charge mode to validate the theoretical analysis. Examine of adding active snubber to eliminate voltage spike on the switches is introduced in the simulation.
Symmetrization of the Crystal Lattice of MAPbI3 Boosts the Performance and Stability of Metal–Perovskite Photodiodes

Semiconducting lead triiodide perovskites (APbI3) have shown remarkable performance in applications including photovoltaics and electroluminescence. Despite many theoretical possibilities for A+ in APbI3, the current experimental knowledge is largely limited to two of these materials: methylammonium (MA+) and formamidinium (FA+) lead triiodides, neither of which adopts the ideal, cubic perovskite structure at room temperature. Here, a volume‐based criterion is proposed for cubic APbI3 to be stable, and two perovskite materials MA1−xEAxPbI3 (MEPI, EA+ = ethylammonium) and MA1−yDMAyPbI3 (MDPI, DMA+ = dimethylammonium) are introduced. Powder and single‐crystal X‐ray diffraction (XRD) results reveal that MEPI and MDPI are solid solutions possessing the cubic perovskite structure, and the EA+ and DMA+ cations play similar roles in the symmetrization of the crystal lattice of MAPbI3. Single crystals of MEPI and MDPI are grown and made into plates of a range of thicknesses, and then into metal–perovskite photodiodes. These devices exhibit tripled diffusion lengths and about tenfold enhancement in stability against moisture, both relative to the current benchmark MAPbI3. In this study, the systematic approach to materials design and device fabrication greatly expands the candidate pool of perovskite semiconductors, and paves the way for high‐performance, single‐crystal perovskite devices including solar cells and light emitters.
Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression

CHD4 is a catalytic subunit of the NuRD (nucleosome remodeling and deacetylase) complex essential in transcriptional regulation, chromatin assembly and DNA damage repair. CHD4 contains tandem plant homeodomain (PHD) fingers connected by a short linker, the biological function of which remains unclear. Here we explore the combinatorial action of the CHD4 PHD1/2 fingers and detail the molecular basis for their association with chromatin. We found that PHD1/2 targets nucleosomes in a multivalent manner, concomitantly engaging two histone H3 tails. This robust synergistic interaction displaces HP1γ from pericentric sites, inducing changes in chromatin structure and leading to the dispersion of the heterochromatic mark H3K9me3. We demonstrate that recognition of the histone H3 tails by the PHD fingers is required for repressive activity of the CHD4/NuRD complex. Together, our data elucidate the molecular mechanism of multivalent association of the PHD fingers with chromatin and reveal their critical role in the regulation of CHD4 functions.
The Role of Macroprudential Policy for Financial Stability in East Asia’s Emerging Economies

This paper analyzes the role and scope of macroprudential policy in preventing financial instability in the context of East Asian economies. It analyzes the behavior of the housing market in a dynamic setting to identify some of the factors responsible for the volatility of housing markets and their susceptibility to boom–bust cycles, which it identifies as a key source of financial imbalances in these economies. It then discusses the causal nexus between price and financial stability and the roles and complementary nature of macroprudential and monetary policies in addressing aggregate risk in the financial system. The paper identifies currency and maturity mismatches, which contributed to the 1997–1998 Asian financial crisis, as ongoing concerns in these economies although the high levels of reserves in the region now act as a buffer.
Formalized Representation of Specifications for Construction Cost Estimation by Using Ontology

Construction cost estimation, which is normally labor‐intensive and error‐prone, is one of the most important works concerned by multiparticipants during a project's life cycle. However, the proficiency of estimators on specifications for construction cost estimation greatly affects the efficiency and accuracy of cost estimation. By formalizing specifications for construction cost estimation, such specifications can be better implemented in computer programs so that the working efficiency and accuracy of estimation can be greatly improved. This study aims to establish an effective approach to formalize such specifications by using ontology. First, two typical specifications for construction cost estimation are analyzed and relevant models are established. Then, an ontology‐based representation of two specifications is established based on the models. Next, a prototype tool for facilitating the establishment, modification, and extension of the ontology‐based representation for estimators is presented and the use cases of the tool are illustrated. Finally, the applicability of the approach is discussed. It is concluded that the formalized representation can be used to classify the building components into items for bill of quantities and quota items automatically by computer programs to accelerate cost estimation.
Hedging with synthetical forwards and the export decision

The paper focusses on currency options as financial hedging instrumenta. Since currency forwards imply the well-known Separation result, it follows for arbitragefree hedging markets that Separation must also hold in option markets if the traded options allow for con-structing a synthetical forward contract. Furthermore export revenue is fully hedged by synthetical forwards, if the risk premium in the put price is equal to the risk premium in the call price.
El valor de marca de las entidades financieras: comparación entre particulares y microempresas mediante el análisis del efecto halo y el modelo de elección discreta

This work aims to quantify brand equity and positioning of financial services institutions, banks and saving banks, both in consumers’ and industrial’ markets. Likewise, there is an attempt to identify the most relevant image dimensions when choosing an institution as the one with the highest overall evaluation. Using a discrete choice model and the analysis of the halo effect we verify the importance of personnel treatment in this markets. Results suggest the higher intensity of halo effect for saving banks in consumers’ markets while in industrial’ ones brand value is higher for banks.
Identification of an Increased Short-Term Blood Pressure Variability on Ambulatory Blood Pressure Monitoring as a Coronary Risk Factor in Diabetic Hypertensives

We examined risk factors for coronary heart disease (CHD) by ambulatory blood pressure (BP) monitoring in 72 diabetic hypertensives who were hospitalized for the educational program. The patients were divided into two groups (CHD group, 19 subjects; and non-CHD group, 53 subjects) along with or without co-existing CHD. On ambulatory BP monitoring, no significant differences were found between the groups regarding BP values through the day. However, the CHD group had a significantly grater BP variability than non-CHD group. The result of logistic regression analysis demonstrated that nighttime systolic BP variability was an independent risk factor for CHD.
Towards a framework for managing corporate identity

Notes how the value of developing corporate identity (CI), as a means of encouraging an organization's key stakeholders to perceive the corporate entity in a clear and positive way, has been receiving increased attention in the last decade. To date much of the practitioner and academic attention has been focused on the communication function between an organization and its customers (primarily). In order that managers and academics are able to realize more of the potential that CI offers organizations, it is necessary to consider the role and impact CI can have on strategic management. Reviews the literature and considers the concepts of corporate identity, image, reputation and personality. Determines the linkages between these concepts and argues that image research studies should not just be oriented to improving images and communications but that this information can also have a central role to play in the strategic development of an organization. To do this presents a framework, referred to as a corporate identity management process (CIMP). Provides an illustration which shows how an understanding of stakeholder images can be used, via the CIMP, to reveal opportunities for developing sustainable competitve advantage.
Preferences towards Online Shopping among Urban Population with special reference to Chennai City

Online shopping is an important aspect of the retail industry at this new era. The online medium, a hybrid of multiple communication technologies, offers a multitude of communication functions, including marketing. As a marketing communication channel, the Internet has attracted nearly one-third of its users to try online shopping during the decade when it became commercialized. This study is to identify the factors that influence the consumers (with special reference to Chennai city) to go for online shopping than the retail shopping. Results indicate that convenience, income, age range, product type, influence consumer intention to engage in online shopping. When consumers perceive offline shopping as inconvenient, their intention to shop online is greater. The attitudes towards online shopping and intention to shop online are not only affected by ease of use, usefulness and enjoyment, but also by exogenous factors like saving time, comparison shopping, product characteristics, previous online shopping experiences, easy to access and trust in online shopping. The Chi-square test was used to determine the relationship.
Nurse Practitioner Student Clinical Evaluation : A Comparison of Preceptor and Faculty Scoring

Evaluating nurse practitioner students’ clinical performance is a vital and challenging role of nursing faculty. Identifying gaps in student knowledge and providing individualized feedback will enhance future clinical performance. Two methods of student evaluation were compared: preceptor clinical evaluation scores and open book exam scores. The two groups of evaluators scored student performance in an initial graduate clinical course, and the scores between evaluators were compared for the same first year course over a four year period (n= 242). For three of the four years, there was weak correlation between faculty scoring open book exams and preceptors scoring student clinical performance. One year (2015) showed a significant correlation between the two evaluation methods. The two evaluation methods provide richer data for student assessment than either method alone. Additional investigation of this potential theory/praxis gap is warranted.
Analysis for reproduced light field of 3D displays

A method has been developed for analyzing the characteristics of light fields reproduced by 3D displays and for determining the maximum depth of images on a 3D display. Use of this method will enable identification of which type of 3D display is best for certain applications and will facilitate the design 3D displays.
The role of MNC's subsidiaries in creating multinational corporate brand

Because of the varying cultural climate in a multinational context, a serious practical problem for management is the lack of a widely agreed framework that can help to define a corporate brand for multinational corporations (MNCs). This is important because the branding of a MNC has several implications and therefore, for newly created multinational corporate brands (MCBs), it is necessary to deal with a series of dichotomies and challenges. MCBs have the potential advantage of alleviating the effect of local customers' ethnocentric tendency in purchasing this brand. However, empirical research in this area is rare. This paper proposes the concept of domestic corporate brands and MCBs and identifies three success factors associated with creating MCBs. This study is one of the first to highlight the concept of s and to identify the success factors that make managing this type of branding.
hesis for the degree of D octor of P hilosophy Multilevel modulation in short-range optical links

Power and cost efficient short-range optical links are one of the technologies enabling large scale high-performance computers and data centers. Such links typically use directly modulated vertical cavity surface emitting lasers, multi-mode fiber, direct detection and on-off keying (OOK) modulation. In this work replacement of OOK with multilevel modulation formats is studied, with possible application in future optical interconnects. Subcarrier modulation and pulse amplitude modulation (PAM) were studied because they can be implemented in systems using intensity modulation and direct detection. Previously known subcarrier modulation formats were found to use the optical power inefficiently. In this thesis optimized subcarrier formats were demonstrated experimentally, in particular a three-dimensional four-level optimized subcarrier format called on-off phase-shift keying with 0.6 dB sensitivity improvement over OOK and 2 dB improvement over subcarrier quadrature phase shift-keying at the same bit rate. Similar sensitivity improvements were demonstrated for eightand sixteen-level subcarrier formats. PAM offers a good trade-off between complexity and sensitivity. It was demonstrated in real-time at bit-rates of up to 60 Gbps with four levels and up to 35 Gbps with eight levels. Practical aspects of its implementation, such as robustness to intersymbol interference and application of forward error correction (FEC) were investigated theoretically and experimentally. It was shown that 4-PAM with FEC can double the throughput relative to OOK in the same system, while retaining similar sensitivity.
Tick Size Constraints, Market Structure, and Liquidity

We argue that a one-penny minimum tick size for all stocks priced above $1 (SEC rule 612) encourages high-frequency trading and taker/maker–fee markets. We find that non-high frequency traders (non-HFTers) are 2.62 times more likely than HFTers to provide best prices, thereby establishing price priority. The larger relative tick size for low priced stocks, however, constrain non-HFTers from providing better prices and HFTers’ speed advantage helps them establish time priority over non-HFTers. Non-HFTers enter the taker/maker market more frequently than HFTers, because they can bypass tick size constraints by paying a fee to the exchange. The incentive to pay a fee is stronger when relative tick size is high. When stock splits increase relative tick size, liquidity does not improve and volume shifts to the taker/maker market. Our results indicate recent proposals to increase tick size will not improve liquidity. Instead, they will encourage high frequency trading and lead to proliferation of markets that bypass the tick size constraints.