Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of CXCL11 as a STAT3-Dependent Gene Induced by IFN1

IFNs selectively regulate gene expression through several signaling pathways. The present study explored the involvement of STAT3 in the IFN-induced expression of the gene encoding the CXCL11 chemokine. The CXCL11 gene was induced in IFN-sensitive Daudi cells, but not in an IFN-resistant DRST3 subline with a defective STAT3 signaling pathway. Although the IFN-stimulated gene ISG15 was induced to a similar extent in Daudi and DRST3 cells, expression of wild-type STAT3 in DRST3 cells restored the IFN inducibility of CXCL11. Reconstitution of STAT3 knockout mouse embryonic fibroblasts with wild-type STAT3, or STAT3 with the canonical STAT3 dimerization site at Y705 mutated, restored IFN inducibility of the CXCL11 gene. These data indicate that CXCL11 gene induction by IFN is STAT3 dependent, but that phosphorylation of Y705 of STAT3 is not required. Chromatin immunoprecipitation assays demonstrated that IFN treatment of Daudi and DRST3 cells induced STAT3 binding to the CXCL11 promoter. Chromatin immunoprecipitation assays also revealed that NF-κB family member p65 and IFN regulatory factor (IRF)1 were bound to CXCL11 promoter upon IFN treatment of Daudi cells. In contrast, IFN induced the binding of p50 and IRF2 to the CXCL11 promoter in DRST3 cells. The profile of promoter binding was indistinguishable in IFN-sensitive Daudi cells and DRST3 cells reconstituted with wild-type STAT3. Thus, STAT3 also plays a role in the recruitment of the transcriptional activators p65 and IRF1, and the displacement of the transcriptional repressors p50 and IRF2 from the CXCL11 promoter also appears to regulate the induction of CXCL11 gene transcription.
Dépendances fonctionnelles : extraction et exploitation

Les dependances fonctionnelles fournissent une information semantique sur les donnees d’une table en mettant en lumiere les liens de correlation qui les unient. Dans cette these, nous traitons du probleme de l’extraction de ces dependances en proposant un contexte unifie permettant la decouverte de n’importe quel type de dependances fonctionnelles (dependances de cle, dependances fonctionnelles conditionnelles, que la validite soit complete ou approximative). Notre algorithme, ParaCoDe, s’execute en parallele sur les candidats, reduisant ainsi le temps global de calcul. De ce fait, il est tres competitif vis-a-vis des approches sequentielles connues a ce jour. Les dependances satisfaites sur une table nous servent a resoudre le probleme de la materialisation partielle du cube de donnees. Nous presentons une caracterisation de la solution optimale dans laquelle le cout de chaque requete est borne par un seuil de performance fixe prealablement et dont la taille est minimale. Cette specification de la solution donne un cadre unique pour decrire et donc comparer formellement les techniques de resume de cubes de donnees.
Exercise Response in Hypertrophic Cardiomyopathy: Blunted Left Ventricular Deformational and Twisting Reserve With Altered Systolic-Diastolic Coupling

Background— Abnormal left ventricular (LV) deformational mechanics have been demonstrated in patients with hypertrophic cardiomyopathy (HCM) at rest, but there is a lack of information on their adaptation to exercise. The aim of this study was to assess the adaptability of LV strains and torsional mechanics during exercise in HCM patients. Methods and Results— Twenty nonobstructive HCM patients (age, 48.3±12.3 years; 14 men) and 20 control subjects underwent speckle-tracking echocardiographic measurement of longitudinal, radial, and circumferential strains, systolic twist, and diastolic untwisting rate (UTR) at rest and submaximal exercise. HCM patients showed lower resting longitudinal (−15.7±5.0% versus −19.4±2.6%, P<0.001) and radial (38.1±11.3% versus 44.7±14.4%, P<0.05) strains but higher circumferential strain (−21.9±4.0% versus −18.8±2.3%, P<0.05) and twist (15.7±3.6° versus 9.3±2.6°, P<0.0001) than control subjects. Exercise induced an increase in all strains in control subjects but only a moderate increase in longitudinal strain (to −18.4±5.0%), without significant changes in radial and circumferential strains or twist in HCM patients. Exercise peak UTR was lower (−119.0±31.5°/s versus −137.3±41.1°/s) and occurred later (137±18% versus 125±11% systolic time, P<0.05) in HCM than in control subjects. A significant relationship between twist and UTR was obtained in control subjects (ß=−0.0807, P<0.001) but not in HCM patients (ß=−0.0051, P=0.68). Conclusions— HCM patients had severely limited strain adaptability and no LV twisting reserve at exercise. They had reduced and delayed UTR with reduced systolic-diastolic coupling efficiency by twist-untwist mechanics.
Comparative Analysis of Chloroplast psbD Promoters in Terrestrial Plants

The transcription of photosynthesis genes encoded by the plastid genome is mainly mediated by a prokaryotic-type RNA polymerase called plastid-encoded plastid RNA polymerase (PEP). Standard PEP-dependent promoters resemble bacterial sigma-70-type promoters containing the so-called -10 and -35 elements. On the other hand, an unusual light- and stress-responsive promoter (psbD LRP) that is regulated by a 19-bp AAG-box immediately upstream of the -35 element has been mapped upstream of the psbD-psbC operon in some angiosperms. However, the occurrence of the AAG-box containing psbD LRP in plant evolution remains elusive. We have mapped the psbD promoters in eleven embryophytes at different evolutionary stages from liverworts to angiosperms. The psbD promoters were mostly mapped around 500–900 bp upstream of the psbD translational start sites, indicating that the psbD mRNAs have unusually long 5′-UTR extensions in common. The -10 elements of the psbD promoter are well-conserved in all embryophytes, but not the -35 elements. We found that the AAG-box sequences are highly conserved in angiosperms and gymnosperms except for gnetaceae plants. Furthermore, partial AAG-box-like sequences have been identified in the psbD promoters of some basal embryophytes such as moss, hornwort, and lycophyte, whereas liverwort has the standard PEP promoter without the AAG-box. These results suggest that the AAG-box sequences of the psbD LRP may have evolved from a primitive type of AAG-box of basal embryophytes. On the other hand, monilophytes (ferns) use another type of psbD promoter composed of a distinct cis-element upstream of the potential -35 element. Furthermore, we found that psbD expression is not regulated by light in gymnosperms or basal angiosperms, although they have the well-conserved AAG-box sequences. Thus, it is unlikely that acquisition of the AAG-box containing psbD promoter is directly associated with light-induced transcription of the psbD-psbC operon. Light- and stress-induced transcription may have evolved independently and multiple times during terrestrial plant evolution.
Regulation of antibody synthesis against Escherichia coli endotoxin. I. Suppressive effect of endogenously produced and passively transferred antibodies.

Cyclical fluctuations of cellular and humoral 19 S antibody synthesis were evoked by one single injection of heat-killed E. coli 055:B5 bacteria into CBA mice. The phenomenon was interpreted as involving feedback suppression of active antibody synthesis by 19 S antibodies. The biologically stable antigen would be prevented from stimulating antibody synthesis by reacting with the initially produced 19 S antibodies. In the absence of further stimulation 19 S-producing cells and serum antibodies would decay, leaving antigen free to initiate a second cycle of antibody synthesis. This hypothesis was supported by the finding that antiserum taken from the time of the first peak could suppress the appearance of a second peak. Antigen and 19 S antibodies injected simultaneously delayed active antibody synthesis which eventually appeared spontaneously. Presumably this represents a more rapid catabolism of the blocking antibodies than of the antigen. 7 S antibodies were not detected against this antigen during the primary response but appeared after intense hyperimmunization. The most sensitive method for detection of 7 S antibodies was inhibition of antibody synthesis by passive transfer of purified 7 S fractions. 7 S antibodies were more potent in inhibiting active antibody synthesis than 19 S antibodies when equal quantities of hemagglutinins were injected.
Tacit Collusion in the Santiago Housing Market

Given the numerous and widely acknowledged benefits of a well-functioning housing market, it is vital to understand the degree of competition in that market, which is the starting point for undertaking any policy tool aimed at improving its efficiency. This paper tests the extent of competition in the housing market in Santiago, Chile using a two-step methodology. In the first step, using a hedonic price model, the Santiago housing market is divided into sub-markets, which are analyzed separately. The second step is the tacit collusion test itself, which compares the industry markup with the business cycle in each sub-market using panel data regression models. Evidence of collusion is found in certain sub-markets.
Upstream Regulatory Sequences Required for Specific Gene Expression in the Ascidian Neural Tube

The relatively simple structure of ascidians and the number of associated molecular resources that are available make ascidians an excellent experimental system for Investigating the molecular mechanisms underlying neural tube formation. The ascidian neural tube demonstrates the same basic morphology as that of vertebrates. We have described the expression of the neural tubespecific gene CiNut1, which is expressed within neural tube precursor cells from the gastrula stage, and along the entire length of the neural tube during its formation. In this study, we focused on the transcriptional mechanisms that regulate CiNut1 expression. We found that an approximately 1.0 kb upstream sequence was able to recapitulate endogenous CiNut1 expression. A deletion analysis showed that the 119 bp upstream fragment containing two ZicL-binding consensus sequences and one Fox core sequence could also drive the neural tube-specific expression. When mutations were Introduced into the distal ZicL binding site (ZicL1), the neural tube-specific expression almost disappeared. Although the Importance of the proximal ZicL site (ZicL2) and the Fox core sequence have yet to be elucidated, we hypothesize that ZicL regulates gene transcription in the entire neural tube of the ascidian.
Effects of short nap and exercise on elderly people having difficulty in sleeping

The purpose of the present study was to examine the effects of short nap and exercise on the sleep quality of elderly people who reported difficulty in sleeping. ‘Interventions’ such as short nap after lunch and moderate‐intensity exercise in the evening were carried out for 4 weeks. After the ‘interventions’, wake time after sleep onset significantly decreased and sleep efficiency significantly increased, which showed that sleep quality was improved. The frequency of nodding in the evening significantly decreased. These results demonstrated that the proper awakening maintenance in the evening was effective in improving sleep quality. After the ‘intervention’, mental health was also improved with improving sleep quality.
Simulation of two compact antipodal Vivaldi antennas with Radiation Characteristics enhancement

In this paper, two compact antipodal Vivaldi antennas (AVA) with improved Radiation Characteristics are presented. U-typed tapered slot edge (U-TSE) AVA and comb-shaped AVA with U-TSE are simulated and optimized. The -10-dB reflection coefficient bandwidth of comb-shaped AVA spans from 2.3 GHz to 18 GHz (7.83~1) and covers 15.7 GHz, while the bandwidth of conventional AVA which has the same dimensions spans from 3.3 GHz to 18 GHz (5.45~1) and covers 14.7 GHz. The U-TSE structure has the capacity to extend the low-end bandwidth limitation and improve the radiation characteristics in the lower frequencies. Compared with the conventional AVA, this modification can miniaturize the electrical size of the AVA antenna about 30%. The results regarding return loss, far field pattern, antenna gain and axial ratio are illustrated.
A Review of Buprenorphine Diversion and Misuse: The Current Evidence Base and Experiences From Around the World

Outpatient opioid addiction treatment with sublingual buprenorphine pharmacotherapy has rapidly expanded in the United States and abroad, and, with this increase in medication availability, there have been increasing concerns about its diversion, misuse, and related harms. This narrative review defines the behaviors of diversion and misuse, examines how the pharmacology of buprenorphine alone and in combination with naloxone influence its abuse liability, and describes the epidemiological data on buprenorphine diversion and intravenous misuse, risk factors for its intravenous misuse, and the unintended consequences of misuse and diversion. Physician practices to prevent, screen for, and therapeutically respond to these behaviors, which are a form of medication nonadherence, are discussed, and gaps in knowledge are identified. Outpatient opioid addiction treatment with sublingual buprenorphine pharmacotherapy experiences from other countries that have varied health care systems, public policies, and access to addiction treatment are shared to make clear that diversion and misuse occur across the world in various contexts, for many different reasons, and are not limited to buprenorphine. Comparisons are made with other opioids with known abuse liability and medications with no known abuse. The objective was to facilitate understanding of diversion and misuse so that all factors influencing their expression (patient and provider characteristics and public policy) can be appreciated within a framework that also recognizes the benefits of addiction treatment. With this comprehensive perspective, further careful work can help determine how to minimize these behaviors without eroding the current benefits realized through improved addiction treatment access and expansion.
GDNF‐induced seminomatous tumours in mouse – an experimental model for human seminomas?

Glial‐cell‐line‐derived neurotrophic factor (GDNF) is a distant member of the transforming growth factor superfamily. It binds to and activates a receptor complex consisting of GFR‐α1 and Ret receptor tyrosine kinase. In testis, GDNF is expressed by Sertoli cells. We have shown by transgenic loss‐ and gain‐of‐function mouse models that GDNF regulates the cell fate decision of undifferentiated spermatogonia. In the GDNF +/− mice, the spermatogonia differentiate in excess leading to the depletion of germ cells. In the mice overexpressing GDNF in testes, undifferentiated spermatogonia accumulate in the tubules, no sperm is produced, and the mice are infertile. After a year, the GDNF overexpressing mice frequently (89%) develop testicular tumours, and most of them are bilateral (56%). All these tumours show the same histological pattern. They are composed of round spermatogonial/gonocytic cells with only a scant cytoplasm. The tumours are locally invasive but do not metastasise. They express germ line markers, are positive for alkaline phosphatase, and aneuploid with a triploid peak. Thus, by several histological, molecular, and histochemical characteristics, the GDNF‐induced tumours mimic classical seminomas in men, but the precursor lesions are apparently different in mouse and man.
Episodic tremors and slip in Cascadia in the framework of the Frenkel‐Kontorova model

The seismic moment for regular earthquakes is proportional to the cube of rupture time. A second class of phenomena, collectively called slow earthquakes, has very different scaling. We propose a model, inspired from the phenomenology of dislocation dynamics in crystals, that is consistent with the scaling relations observed in the Cascadia episodic tremor and slip (ETS) events. Two fundamental features of ETS are periodicity and migration. In the northern Cascadia subduction zone, ETS events appear every 14.5 months or so. During these events, tremors migrate along‐strike with a velocity of 10 km/day and simultaneously zip back and forth in the relative plate‐motion direction with a typical velocity of 50 km/h. Our model predicts the formation of a sequence of slip pulses on the boundary of the plates, which describes the major features of fault dynamics, including periodicity and the migration pattern of tremors.
Задачи и методы определения атрибутов пользователей социальных сетей (Problems and Methods for Attribute Detection of Social Network Users )

Рост популярности онлайновых сервисов социальных сетей — основных источников персональных данных о пользователях Интернета — открывает беспрецедентные возможности для решения исследовательских и бизнес-задач, а также создания вспомогательных сервисов и приложений для пользователей социальных сетей. Определение неизвестных атрибутов пользователей является одной из фундаментальных проблем анализа социальных данных. В представленной работе рассмотрены методы решения некоторых актуальных задач, связанных с определением скрытых пользовательских атрибутов: поиск сообществ пользователей, определение демографических атрибутов пользователей, а также идентификация пользователей в различных социальных сетях.
Development and Evaluation of Essentials of Magnetism Tool

Staff nurses in 14 magnet hospitals identified 8 attributes associated with the original concept of magnetism as essential to their ability to give quality care. The 8 Essentials of Magnetism (EOM) tool was generated from participant observation and interviews with 289 magnet hospital staff nurses. The psychometric properties of the EOM tool were established in a study involving 3602 staff nurses in 16 magnet and 10 nonmagnet hospitals. The authors discuss the EOM tool and its use in diagnosing elements needed in the environment to produce what staff nurses say is essential for productivity of quality patient care.
Study of structural changes in placenta in pregnancy-induced hypertension

Background: Hypertension is one of the most common complication during pregnancy. It contributes significantly to maternal and perinatal morbidity and mortality. This study was designed to investigate the morphological and histopathological changes in placenta from pregnancies complicated with hypertension. Objectives: To study the morbid changes in placenta in cases of pregnancy-induced hypertension (PIH) and to correlate the findings with birth weight of new born babies in comparison with normotensive mothers. Materials and Methods: The study was done on 100 placentas, out of which 50 were collected from normotensive mothers and the remaining 50 from PIH cases. All the placentas were studied morphologically and histologically. The birth weight of neonates was recorded. Results: In the present study it was observed that weight and dimensions of placenta was less in study group when compared with control group. The mean neonatal birth weight was more in normal pregnancy and feto-placental weight ratio was significantly high in hypertensive group. Histopathological study showed significant number of syncitial knots, areas of fibrinoid necrosis, hyalinization, calcification, and medial coat proliferation of medium sized blood vessels in hypertensive group. Conclusion: PIH significantly affects the placenta by reducing its weight and dimensions. These changes may cause placental insufficiency as a result of compromised utero-placental blood flow. Therefore has an adverse affect on the neonatal birth weight. PIH has definite influence on morphology, histology of placenta, and thus affects the growth of the fetus.
The long-term development impacts of international migration remittances for sending households: evidence from Morocco

Abstract We integrate qualitative and quantitative methods to document the long-term impact of international migration remittances on household investment strategies, wealth outcomes, and equity of asset ownership among households in a Moroccan oasis valley. In the early 1960s, nearly 80,000 Moroccan men from the south-eastern oases left their families to work in French coal mines. Anthropological fieldwork shows that this migration event initiated decades-long streams of steady income in the forms of remittances and pension checks. Accompanying household-level empirical analysis shows that this afforded the migrant-sending households a foothold in the ‘new’ economy: Households invested in vocational training, secondary schooling, and business ownership at rates higher than their non-sending counterparts. Migration also hastened the transition of households out of the ‘old economy’ – land and livestock ownership declined for migrant-sending households, particularly those owning more land. We also document that the migration event was unusually open – work in the coal mines was open to virtually anyone – meaning that the recruits came from across the entire class- and economic spectrum. The combination of an unusually low entry cost and the resultant provision of a large and long flow of cash meant that overall, migration was an equalizing force in the economy.
The Cost-Effectiveness of Syndromic Management in Pharmacies in Lima, Peru

Background Many people with sexually transmitted diseases (STDs) in Lima, Peru, seek treatment in pharmacies. Goal The goal was to assess the cost-effectiveness of training pharmacy workers in syndromic management of STDs. Study Design Cost-effectiveness from both the program and societal perspectives was determined on the basis of study costs, societal costs (cost of medicine), and the number of cases adequately managed. The latter was calculated from estimated incidence, proportion of symptomatic patients, proportion seeking treatment in pharmacies, and proportion of cases adequately managed in both comparison and intervention districts. Univariate and multivariate sensitivity analyses were performed. Results Under base-case assumptions, from the societal perspective the intervention saved an estimated US$1.51 per case adequately managed; from the program perspective, it cost an estimated US$3.67 per case adequately managed. In the sensitivity analyses, the proportion of females with vaginal discharge or pelvic inflammatory disease who seek treatment in pharmacies had the greatest impact on the estimated cost-effectiveness, along with the medication costs under the societal perspective. Conclusion Training pharmacists in syndromic management of STDs appears to be cost-effective when only program costs are used and cost-saving from the societal perspective. Our methods provide a template for assessing the cost-effectiveness of managing STD syndromes, on the basis of indirect estimates of effectiveness.
Meal Pattern and Nutrient Intake Among Adult Finns

The purpose of this study was to investigate the relationship between meal pattern and diet. Nutrient contents of meals, snacks and other eating occasions were compared and differences in dietary intake analysed between respondents following a conventional meal pattern and others. A random sample of 1861 adults aged 25-64 from four regions of Finland completed a mailed questionnaire and 3-day food record in the spring of 1992. A conventional meal pattern was defined on the basis of national dietary guidelines as including breakfast, warm lunch and warm dinner, and subjects were identified with the help of the questionnaire. Meals and snacks were defined according to the respondents subjective criteria. Forty-four percent of all respondents followed the conventional meal pattern. Meal pattern has no effect on nutrient intake in men and small effects in women. Women following the conventional meal pattern had higher energy and cholesterol intake and lower alcohol and vitamin C intake than other women. Meals contributed to energy, protein and fat intake, and snacks to sugar and alcohol. Meal pattern had only a small effect on diet and conventional meal pattern cannot be considered healthier than other meal patterns.