Miracle-dz/UniFAR-FTUs huggingface dataset:
Logistics Competencies, Skills, and Training

Despite the spread of automation and new supply chain management paradigms, logistics remains dependent on a rather specific set of skills and competencies, whether for managerial, administrative, or blue-collar jobs, such as trucking or warehousing. This dependence implies that the logistical performance of businesses, industries, and nation states is strongly influenced by the quantity and quality of the workforce. Insufficient resources of a competent and properly trained workforce in logistics adversely affect the quality of service, reduce productivity in sectors dependent on logistics, and ultimately reduce trade competitiveness. While other interventions that affect logistics performance—such as international infrastructures, trade corridors, regulations, and services—have already been reviewed extensively, this report is the first to cover the contributions of human resources and explore how to develop skills and improve competencies, especially in developing countries. The study proposes a framework for the skills needed according to the logistics activity (such as transportation or warehousing) or the type and level of responsibility. Based on several sources, including recent surveys carried out by the World Bank and the Kuhne Logistics University, the report uncovers where the skills constraints are according to the type of job or countries. Findings include that logistics is an industry struggling to hire skilled workers, although with differences between developed countries (where trucker shortages are more acute) and developing economies (where managerial shortages are more widespread). Typically, blue-collar logistics jobs have lower status and lower pay than blue-collar jobs in other industries; they are thus less attractive for skilled workers. In developing countries with a potentially available workforce, lack of vocational preparation for careers in logistics means that less-skilled workers are not easily re-skilled. Logistics tasks at the upper end of the occupational hierarchy and those with high information technology content often require an upskilling of employees to keep pace with new technology. Yet the problem is not confined to recruitment. The surveys point to limited resources, money, and staff time allocated to training, especially in developing countries. Realizing the promise of quality jobs from the growth of logistics worldwide requires a coordinated effort by logistics companies, professional associations, training providers, and policy makers. Through a combination of facilitation, regulation, advice, financial instruments, and land use planning, governments can exert significant influence.
Ultrastructure of endocrine pancreatic granules during pancreatic differentiation in the grass snake, Natrix natrix L. (Lepidosauria, Serpentes)

We used transmission electron microscopy to study the pancreatic main endocrine cell types in the embryos of the grass snake Natrix natrix L. with focus on the morphology of their secretory granules. The embryonic endocrine part of the pancreas in the grass snake contains four main types of cells (A, B, D, and PP), which is similar to other vertebrates. The B granules contained a moderately electron‐dense crystalline‐like core that was polygonal in shape and an electron‐dense outer zone. The A granules had a spherical electron‐dense eccentrically located core and a moderately electron‐dense outer zone. The D granules were filled with a moderately electron‐dense non‐homogeneous content. The PP granules had a spherical electron‐dense core with an electron translucent outer zone. Within the main types of granules (A, B, D, PP), different morphological subtypes were recognized that indicated their maturity, which may be related to the different content of these granules during the process of maturation. The sequence of pancreatic endocrine cell differentiation in grass snake embryos differs from that in many vertebrates. In the grass snake embryos, the B and D cells differentiated earlier than A and PP cells. The different sequence of endocrine cell differentiation in snakes and other vertebrates has been related to phylogenetic position and nutrition during early developmental stages.
A Semantic Recommender System for Adaptive Learning

The ever-more complex labor world and the current economic crisis ask learners and workers to continuously update their qualification levels to stay relevant on the job. Hence, education and training providers need to adjust their offerings to cope with such evolving requirements. However, the huge number of variables to consider means that finding the right learning content that lets an individual fill his or her competency gap might be difficult. The authors' semantic-based recommender system crosses heterogeneous information about learners' and workers' backgrounds as well as advertised job positions with a catalog of online courses to identify the most appropriate learning resources. Experimental observations showed a good agreement between human and automatic recommendations, confirming the applicability of the emerging semantic technology to the generation of user-centered services that can adapt to individuals' learning needs. The authors discuss the details of their system in a video Web extra at http://youtu.be/A8c5MwnlGvA. A second Web extra shows the training booklet for evaluating the authors' system and the results of the automatic recommendation; it's available at https://s3.amazonaws. com/ieeecs.cdn. csdl.public/mags/it/2015/05/mit2015050050s.pdf.
The Meaning of Surviving Cancer for Latino Adolescents and Emerging Young Adults

Adolescent and young adult (AYA) survivors of cancer are an understudied population with unique developmental and medical needs that extend well beyond their active treatment. Survivors diagnosed as AYAs may experience both physical and emotional late effects. In particular, the experiences of Latino cancer survivors have not been explored. The purpose of this study was to conduct interviews with AYA Latino cancer survivors to inform professionals working with these survivors. A hermeneutic phenomenological approach was selected based on the focus on experiences and meanings of Latino adolescents' cancer survivorship. Phenomenology allows for understanding the subjective meaning and lived experience of populations that are understudied or marginalized. In-depth interviews were conducted with participants. Enrolled in the study were Latino AYAs between the ages of 14 and 21 years, after treatment. Interviews revealed 7 themes regarding the experience and meaning of survivorship for this population: gratitude, humor/positive attitude, empathy for younger children with cancer, God and faith, cancer happens for a reason/cancer changed my life, familial support, and staff relationships. Latino AYA cancer survivors develop meaning out of unique cancer experiences. Programs need to be developed specifically to address Latino adolescents and young adult survivors of cancer.
Endothelial K(+) channel lacks the Ca(2+) sensitivity-regulating beta subunit.

Hyperpolarizing large-conductance, Ca(2+)-activated K(+) channels (BK) are important modulators of vascular smooth muscle and endothelial cell function. In vascular smooth muscle cells, BK are composed of pore-forming alpha subunits and modulatory beta subunits. However, expression, composition, and function of BK subunits in endothelium have not been studied so far. In patch-clamp experiments we identified BK (283 pS) in intact endothelium of porcine aortic tissue slices. The BK opener DHS-I (0.05-0.3 micromol/l), stimulating BK activity only in the presence of beta subunits, had no effect on BK in endothelium whereas the alpha subunit selective BK opener NS1619 (20 micromol/l) markedly increased channel activity. Correspondingly, mRNA expression of the beta subunit was undetectable in endothelium, whereas alpha subunit expression was demonstrated. To investigate the functional role of beta subunits, we transfected the beta subunit into a human endothelial cell line (EA.hy 926). beta subunit expression resulted in an increased Ca(2+) sensitivity of BK activity: the potential of half-maximal activation (V(1/2)) shifted from 73.4 mV to 49.6 mV at 1 micromol/l [Ca(2+)](i) and an decrease of the EC(50) value for [Ca(2+)](i) by 1 microM at +60 mV was observed. This study demonstrates that BK channels in endothelium are composed of alpha subunits without association to beta subunits. The lack of the beta subunit indicates a substantially different channel regulation in endothelial cells compared to vascular smooth muscle cells.
Lumbar spine MRI for low back pain: indications and yield.

OBJECTIVE Low back pain is one of the most common causes of physician visits in the United States with an enormous socioeconomic burden. Because of this burden, numerous studies have focused on its diagnosis and management. New technologies have been quickly adopted with the hope that they will improve our understanding of the physiopathology of the disease and assist us in alleviating patients' pain and discomfort. Unfortunately, previous studies have not been able to show that higher utilization of advanced imaging technology is associated with improvements in patient outcome. This article highlights practices that are evidence-based versus those that are common, or heterogeneous, but not supported by existing evidence. We also highlight outstanding areas for further research. CONCLUSION Clinicians and researchers should be encouraged to follow standardized practices in accordance with evidence-based medicine guidelines. The use of such guidelines will decrease variation in care, allowing researchers to more easily design and conduct comparative effectiveness studies of diagnostic imaging.
A Structural Basis for the Inhibition of the NS5 Dengue Virus mRNA 2′-O-Methyltransferase Domain by Ribavirin 5′-Triphosphate*

Ribavirin is one of the few nucleoside analogues currently used in the clinic to treat RNA virus infections, but its mechanism of action remains poorly understood at the molecular level. Here, we show that ribavirin 5′-triphosphate inhibits the activity of the dengue virus 2′-O-methyltransferase NS5 domain (NS5MTaseDV). Along with several other guanosine 5′-triphosphate analogues such as acyclovir, 5-ethynyl-1-β-d-ribofuranosylimidazole-4-carboxamide (EICAR), and a series of ribose-modified ribavirin analogues, ribavirin 5′-triphosphate competes with GTP to bind to NS5MTaseDV. A structural view of the binding of ribavirin 5′-triphosphate to this enzyme was obtained by determining the crystal structure of a ternary complex consisting of NS5MTaseDV, ribavirin 5′-triphosphate, and S-adenosyl-l-homocysteine at a resolution of 2.6 Å. These detailed atomic interactions provide the first structural insights into the inhibition of a viral enzyme by ribavirin 5′-triphosphate, as well as the basis for rational drug design of antiviral agents with improved specificity against the emerging flaviviruses.
Energy-dependent conversion of transformed cytosolic glucocorticoid receptors from soluble to particulate-bound form.

We have recently published that soluble cytosolic glucocorticoid receptors are converted to a particulate form when they are incubated at 37 degrees C in a tubulin-polymerizing buffer [Pratt, W. B. , Sanchez, E. R. , Bresnick, E. H. , Meshinchi, S. , Scherrer, L. C. , Dalman, F. C. , & Welsh, M. J. (1989) Cancer Res. (Suppl.) 49, 2222s-2229s]. In this work, we further define this phenomenon and demonstrate that the L-cell glucocorticoid receptors are binding to a protein particulate composed largely of cytoskeletal proteins. Incubation of L-cell cytosol with glutamate at 37 degrees C converts the glucorticoid receptor to a form that pellets when cytosol is centrifuged at 150000g. The particulate material formed in a temperature-dependent and glutamate-dependent manner contains a large amount of tubulin, actin, and vimentin, but it is not the product of a cold-labile, colchicine-sensitive polymerization process. Very few cytosolic proteins are present in this complex, but the glucocorticoid receptor is tightly bound to it. Binding of the receptor to the cytoskeletal complex occurs after receptor transformation and is at least partially energy-dependent. Examination of the behavior of beta-galactosidase receptor fusion proteins and the nti glucocorticoid receptor demonstrates that residues 445 to the COOH-terminus of the receptor (DNA-binding and hormone-binding domains) contain the features required for binding to the cytoskeletal complex. Although it is the transformed receptor that associates tightly with the complex, DNA-binding activity is not required for association with the cytoskeletal particulate. (ABSTRACT TRUNCATED AT 250 WORDS)
Novel cycle changes in scalp hair are caused by etretinate therapy

The scalp hair of 15 patients, who were treated with etretinate for at least 6 months, was investigated, with the aims of confirming the previously described reduction in the duration of anagen and establishing the mechanism of etretinate alopecia. An increase in hair shedding rate and an increase in plucked telogen count, both of which continued for 6 months of treatment, were found, whereas there was no significant increase in the proportion of new, or regrowing, anagen hairs in a cut sample(NAH). The sustained decrease in the duration of anagen was confirmed, and it was further shown that this decrease was progressive. This would appear to be the main cause of the observed increased shedding associated with etretinate treatment. In relation to the mechanism of the alopecia, it was concluded that an arrest at the onset of anagen and a follicular anchorage defect in telogen were causes. The evidence for an arrest at the onset of anagen was a failure of NAH to rise on treatment, and a large increase in NAH on stopping treatment. The evidence for a follicular anchorage defect was a rise in shed rate very early in treatment, and an observed shed rate greater than expected, on the basis of plucked telogen results, later in treatment.
MYCOBACTERIUM INTRACELLULARE INFECTION IN A CAPYBARA (HYDROCHOERUS HYDROCHAERIS)

Abstract: This report describes the first case of Mycobacterium intracellulare infection with typical granulomatous lesions of mycobacteriosis in a capybara (Hydrochoerus hydrochaeris). The individual was a captive-bred young female, part of the control group of an experimental study on stress. Multiple granulomatous lesions were detected in a mesenteric lymph node of this young female. Mycobacterial infection was confirmed by bacteriologic culture and molecular identification methods. Clinical lesions were characterized by histopathology.
Heartburn without oesophagitis: efficacy of omeprazole therapy and features determining therapeutic response.

BACKGROUND Data are limited on the value of effective antisecretory therapy in the relief of heartburn in patients without oesophagitis. METHODS Patients with heartburn, without endoscopic signs of oesophagitis, were randomized to double-blind treatment with omeprazole, 20 or 10 mg once daily, or placebo, for 4 weeks (n = 509). Pre-treatment oesophageal acid exposure was assessed using 24-h intra-oesophageal pH monitoring. Heartburn was assessed at 2 and 4 weeks. RESULTS At 4 weeks the proportion of patients with complete absence of heartburn was 46% (95% confidence interval, 39-53%) with 20 mg omeprazole, 31% (25-38%) with 10 mg omeprazole, and 13% (7-20%) with placebo. Satisfaction with therapy was reported by 66%, 57%, and 31% of the patients, respectively. CONCLUSION Omeprazole, 20 and 10 mg once daily, provides rapid relief of heartburn in patients without endoscopic oesophagitis.
Pain, Cannabis Species, and Cannabis Use Disorders.

OBJECTIVE The purpose of this study was to examine whether individuals who used medical cannabis for chronic pain were at increased risk for cannabis use problems compared with individuals who used medical cannabis for other reasons (e.g., anxiety, insomnia, and muscle spasms). An additional aim was to determine whether individuals who used cannabis for chronic pain, as well as those who reported greater within-group pain levels, demonstrated a species preference (i.e., sativa, indica, hybrids) and the extent to which species preference was associated with cannabis use problems. METHOD Participants were 163 medical cannabis users (77% male), recruited from a medical marijuana dispensary in California, who completed assessments of medical cannabis use motives, history, preferences (species type), and problems, as well as current pain level. RESULTS Individuals who used cannabis to manage chronic pain experienced fewer cannabis use problems than those who did not use it for pain; among those who used it for pain, the average pain level in the past week was not associated with cannabis use problems. Furthermore, individuals who used cannabis for chronic pain were more likely to use indica over sativa. Preference for indica was associated with fewer cannabis use problems than preference for hybrid species. CONCLUSIONS Individuals who use cannabis to manage chronic pain may be at a lower risk for cannabis use problems, relative to individuals who use it for other indications, potentially as a function of their species preference.
Solution Focused Classroom Guidance

Solution Focused Counseling as a classroom guidance intervention can have a positive effect in a classroom setting. Solution Focused Classroom Guidance curriculum provides a useful framework for professional school counselors and teachers to present a positive, hopeful, and beneficial paradigm for students. Solution Focused Classroom Guidance facilitates discussion, processing, and learning leading to a ripple effect which cultivates a positive solution focused classroom. The findings of this study suggest that a SF guidance curriculum can be an important characteristic of positive changes in classroom environment.The study provides empirical support for the theorized notion that those outside the SF treatment can observe measurable change, as demonstrated by the classroom teachers of this study. Solution Focused Classroom Guidance can change classroom climate.
Benefits of intensive resistance training in patients with chronic polymyositis or dermatomyositis.

OBJECTIVE To investigate the benefits and safety of an intensive muscular training program in patients with chronic polymyositis (PM) and dermatomyositis (DM). METHODS Nine patients with chronic PM or DM (median age 53 years, range 44-61) were included. Assessments of impairment (10-15 voluntary repetition maximum [VRM], the Functional Index 2 [FI-2], the Grippit, and pain rated on the Borg CR-10 scale), activity limitation (Myositis Activities Profile), and participation restriction (patients' disease impact on well-being) were performed 4 weeks prior to baseline, at baseline, and after 7 weeks of exercise. A 6-item core set of disease activity measures was administered and muscle biopsy samples of vastus lateralis were obtained at baseline and after 7 weeks of exercise. Response criteria at an individual level were set for disability and disease activity. The patients exercised 3 days per week for 7 weeks on loads allowing 10 VRM. RESULTS On a group level there were no significant differences between assessments at 4 weeks before baseline compared with baseline. The group improved significantly regarding 10-15 VRM and FI-2 at 7 weeks compared with baseline (P < 0.05). All patients were responders with respect to impairment and 2 were activity limitation responders whereas participation restriction remained unchanged in all. Two patients were responders with reduced disease activity and no patient had signs of increased muscle inflammation in the muscle biopsy sample after 7 weeks of exercise. CONCLUSION Patients with chronic, stable PM and DM can perform this intensive resistive exercise program with beneficial effects on impairment and activity limitation without increased muscle inflammation.
Rate-Distortion-Optimization-Based Quantization Parameter Cascading Technique for Random-Access Configuration in H.265/HEVC

The random-access configuration is employed in H.265/HEVC video coding to make inter-frame prediction more efficient. The coding efficiency under the random-access configuration is closely related to the quantization parameter cascading (QPC) technique which determines the QP for encoding pictures in different temporal layers. The present QPC technique for the random-access configuration in H.265/HEVC is not optimized. In this paper, first, a rate-distortion-optimization-based technique for QPC, referred to as RDO-QPC, is proposed for the random-access configuration in H.265/HEVC. Based on the results from RDO-QPC, a simplified QPC technique, referred to as SRDO-QPC, is proposed. The experimental results verify the efficiency of the proposed two QPC techniques. Compared with the original configuration of QPC in H.265/HEVC, RDO-QPC achieves an average gain of 0.19 dB in <inline-formula> <tex-math notation="LaTeX">$\Delta \text {PSNR}$ </tex-math></inline-formula> and an average reduction of 4.87% in <inline-formula> <tex-math notation="LaTeX">$\Delta \text {BR}$ </tex-math></inline-formula>, while SRDO-QPC achieves an average gain of 0.17 dB in <inline-formula> <tex-math notation="LaTeX">$\Delta \text {PSNR}$ </tex-math></inline-formula> and an average reduction of 4.32% in <inline-formula> <tex-math notation="LaTeX">$\Delta \text {BR}$ </tex-math></inline-formula>. These two QPC techniques can both be used in practical situations, meeting different requirements of computational complexity.
A Death in Venice

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An Investigation of Assessment, Equal Opportunity, and Educational Equity in Conservative Evangelical Schools

The purpose for this ex post facto, causal comparative study was to use a three-tiered investigation; each tier was related to the investigation of equity and student achievement. Based on the literature, there is little to no research about the relationship between equity in conservative Evangelical Christian schools and student achievement. The data used in this study was drawn from conservative Evangelical schools. The research focus was on schools which are members of the Association of Christian Schools International (ACSI) in the Mid-America/Ohio River Valley Region. The participant schools were divided into different tiers and categories, in accordance with the size, tuition, and location. With use of the variables of location, school size, and cost per student, an ANOVA was used to analyze student achievement solely in ACSI member schools. Three separate ANOVAs were used to analyze the data for each part of the study. The first ANOVA was used to analyze student achievement in ACSI schools with regard to location; the second ANOVA was used to analyze student achievement in ACSI schools with regard to tuition; and the final ANOVA was used to analyze student achievement in ACSI schools with regard to enrollment size. The instrument used for measuring student achievement in this study was the Terra Nova Test (3 Edition) for ACSI schools.