Miracle-dz/UniFAR-FTUs huggingface dataset:
Ruhsal Hastalıklarda Gevşeme Eğitiminin Ağrı, Yorgunluk Ve Uyku Üzerine Etkisinin İncelenmesi

Amac: Ruhsal hastaliklar ciddi emosyonel, davranissal ve fiziksel saglik sorunlarina neden olabilir. Fiziksel sorunlar uyku bozuklugu, istah sorunu, agri, uyusukluk, yorgunluk gibi belirtiler icermektedir. Bu calisma ruhsal hastaliklarda gevseme egitiminin agri, yorgunluk siddeti ve uyku sorununa etkisini incelemek amaciyla planlandi. Gerec ve yontem: Calismaya ruhsal bozukluklari olan bireylerden yas ortalamasi 38.42±13.65 yil olan 15 kadin, 4 erkek olmak uzere 19 gonullu dâhil edildi. Gorsel Analog Skala (GAS) ile agri, yorgunluk siddeti ve uyku sorunu mudahale oncesi ve sonrasi degerlendirildi. Mudahale programinda haftada 2 kez 5 hafta toplam 10 seans solunumla kombine progresif kas gevseme ve postur egitimi verildi. Sonuclar: Bireylerin agri duzeyi (p=0,007), yorgunluk siddeti (p=0,001) ve uyku sorunu (p=0,001) egitim oncesi ve sonrasi karsilastirildiginda istatistiksel olarak anlamli farkliliklar bulunmustur. Tartisma: Calismadan elde edilen veriler dogrultusunda gevseme egitiminin agri, yorgunluk ve uyku sorununun giderilmesi acisindan iyilestirici etkileri ortaya koyulmustur. Ruhsal hastaliklarin rutin tedavisine gevseme egitiminin dâhil edilmesi faydali olacaktir. Uzun donem takibin yapildigi, teshis acisindan homojen gruplarin dâhil edildigi ileri calismalara ihtiyac vardir.
PREVALENCE OF PREHYPERTENSION AND THE NEAR TERM RISK OF DEVELOPING HYPERTENSION AMONG ARABIAN GULF UNIVERSITY MEDICAL STUDENTS IN THE KINGDOM OF BAHRAIN FOR THE YEAR 2011-2012.

This research mainly aims to estimate the prevalence of prehypertension among medical students in the Arabian Gulf University (AGU) in the Kingdom of Bahrain for the year 2011-2012. It also provides a baseline data of the blood pressure status among medical students above 20 years in the University. This includes identifying the factors contributing to the blood pressure variation. Also acknowledging the near-term risk of developing hypertension in the upcoming first, second and fourth years by using the risk score. [1] The method used in this research was multistage stratified sampling from the population. The procedure included going to the administration and registration unit of the university, which supplied a table of information regarding the number, the gender and date of birth of the students in each academic year. Before the actual study took place, a pilot study was done and the research data was entered and analyzed by SPSS 16. As for the principle results, we concluded that the prevalence of prehypertension among AGU medical students in the Kingdom of Bahrain, who aged 20 years and above was found to be 37.35%, with a gradual increase of the mean risk of developing hypertension as a student moved from one academic year to the next. According to our study, there is a significant positive association between blood pressure status with BMI and with gender.
Identification d'un profil de marqueurs périphériques lié aux scores cognitifs dans le plasma et les vésicules extracellulaires durant le développement de la maladie d'Alzheimer: évolution de marqueurs liés au stress oxydatif et aux mécanismes physiopathologiques.

XI TABLE DES MATIÈRES . XV LISTE DES TABLEAUX . XX LISTE DES FIGURES . XXII LISTE DES ABRÉVIATIONS . XXVI CHAPITRE I . 1 1. REVUE DE LITTERATURE . 1 1.1. La maladie d’Alzheimer . 1 1.1.1. Historique. 1 1.1.2. Épidémiologie . 3 Prévalence et incidence de la maladie . 3 1.1.2.a. 1.2. Les différentes formes de la maladie d’Alzheimer et ses facteurs de risque . 4 1.2. 1. La forme familiale . 4 La protéine précurseur de l’amyloïde (APP) . 4 1.2. 1.a. La préséniline 1 (PSEN1) . 7 1.2. 1.b. La préséniline 2 (PSEN2) . 8 1.2. 1.c. 1.2. 2. La forme sporadique multifactorielle . 8 Facteurs de risques génétiques . 8 1.2. 2.a. L’Apolipoprotéine E . 9 Les études d’association pangénomique (GWAS) . 11 Facteurs de risque non génétiques . 11 1.2. 2.b. 1.3. Caractéristiques cliniques et histopathologiques . 12 1.3. 1. Caractéristiques cliniques et les différents stades . 12
Clinical Significance of JAK2 V617F Homozygosity in the Chronic Myeloproliferative Disorders. A Study on 1306 Patients.

The JAK2 V617F mutation is variably found in the Ph’-negative chronic myeloproliferative disorders (MPD); in about 25% of polycythemia vera (PV) or idiopathic myelofibrosis (IM) and in 1–3% of essential thrombocythemia (ET) patients (pts), mitotic recombination causes the mutation to be harboured in the homozygous status. While it has been suggested that homozygosity influences some cellular functions, its clinical significance has not been elucidated yet due to the low number of homozygotes in published series. To this end, a retrospective, multicentric study, that enrolled 1306 pts, was designed within the Myeloproliferative Working Group of the Italian GIMEMA association; all pts who had been typed for JAK2 mutation using the BsaXI digestion assay (Baxter et al, Lancet, 2005) were included. There were 397 PV (30.4%), 639 ET (48.9%), 270 IM (20.7%) pts. JAK2 V617F was found in 878 (67.3%), accounting for 82%, 60%, and 64%, respectively, of PV, ET, or IM pts. The homozygotes (Ho) were 183 (20.8%), with a frequency of 26.3% in PV, 2.2% in ET, and 24.1% in IM. Ho pts, irrespectively of the underlying diagnosis, presented higher leukocyte count and hematocrit, while platelet count was lower, as compared to heterozygous (He) or wild-type (WT). The frequency of splenomegaly rose from 26% to 41% to 52% in WT, He and Ho PV pts; from 19% to 22% to 62% in ET; and from 61% to 67% to 89% in IM. Acquagenic pruritus was referred by 12%, 28% and 42% of WT, He, and Ho PV pts, while the corresponding figures were 4%, 12%, and 26% in IM; no difference was noted among ET pts. Also the frequency of systemic symptoms was significantly higher among Ho pts in all three disease groups. 195 pts (14.9% of total) presented major thromboses at diagnosis (71 PV, 114 ET, 10 IM, accounting for 18%, 18%, and 4% in each group, respectively), while 144 events were recorded in the follow-up (15%, 12%, 4% in PV, ET, or IM). The incidence of thrombosis at diagnosis was 12%, 21% and 15% in WT, He or Ho PV pts, while the corresponding figures were 11%, 22% and 50% in ET, and 1%, 7% and 3% in IM. The relative risk (RR) for major thrombosis after diagnosis (adjusted for gender, age, and previous thrombosis) was significantly higher in Ho than in He pts both in ET (RR 4.6 and 1.5, respectively, by taking as 1 the WT pts) and IM (RR 3.2 and 1.6) pts, unlike in PV (RR 0.8 and 0.9, respectively). Ho pts evolved more frequently into myeloid metaplasia than He or WT in both PV (12% vs 0% and 1%, respectively) and ET (14% vs 5%, and 2%). These data support the contention that the JAK2 V617F homozygous mutational status associates with a more symptomatic disease across the MPD clinical entities, and identify the unfrequent Ho ET patients as a specific subgroup with a particularly aggressive disease.
Promoting Foreign Direct Investment in the Indo-Pacific Region: Scope and Opportunities

Indo-Pacific construct has picked up a motivating pace in recent years. Several countries across the world have shown their interest in joining the Indo-Pacific region. Indo-Pacific region has been the world’s leading source and destination of foreign investment. This article analyses the trends in investment, bilateral and multilateral investment engagements and investment barriers and presents a way to promote foreign direct investment (FDI) in the Indo-Pacific region. It also examines India’s investment relations with some of the Indo-Pacific countries. Further, it looks into the inter-linkages between FDI and global value chain, given that multinational firms play a significant role in bringing international sourcing, technology sharing, and production networking across countries.
Quality standards, implementation autonomy, and citizen satisfaction with public services: cross-national evidence

ABSTRACT This article investigates whether citizens’ evaluations of service performance are related to archival measures of performance, and how institutional context shapes this relationship contingent on administrative autonomy – standards, human resources, and financial autonomy. Using cross-national education data, this study finds that student performance is positively associated with parental evaluations of schools. Perceptions are more closely aligned with performance when agencies have greater autonomy in managing employees, and when national-level bureaucracies set performance standards. This research advances our understanding of the role of administrative autonomy in citizen satisfaction and provides implications for the institutional designs that can benefit performance assessment.
Cultural Variations in Resilience Capacity and Posttraumatic Stress: A Tri-Cultural Comparison

Resilience capacity has been associated with individuals’ flexibility and adaptability in responding to potential trauma. Culture-related appraisals influence not only interpretations of etiology of posttraumatic stress disorder (PTSD) and perception of severity of PTSD symptoms but also flexible coping strategies. However, adequate research of the mechanisms on how culture may affect the relationship between resilience and PTSD does not yet exist. The present study focused on whether and how culture (America, Hong Kong, and Mainland China) moderated the relationship between resilience capacity and severity of posttraumatic distress. Data were collected at three research sites (America, Hong Kong, and Mainland China) where 558 trauma survivors were recruited. Measures included the Life Events Checklist (LEC-5), the PTSD Checklist for DSM-5 (PCL-5), and the Revised Connor-Davidson Resilience Scale (CD-RISC-R). The results of one-way analysis of variance (ANOVA) indicated that American participants were more resilient than the participants in Hong Kong and Mainland China. The results of multiple regression indicated that frequency of exposure to trauma was a weaker predictor of severity of PTSD symptoms at high versus low levels of resilience capacity. The results also indicated a weaker moderating effect of Hong Kong versus American culture on the relation between resilience capacity and PTSD. This pilot study highlighted East–West cultural differences in the baselines of resilience capacity and posttraumatic stress and may motivate clinicians and researchers to reevaluate Western diagnostic criteria to psychological trauma conceptualization and treatment for non-Western populations.
Experiencia del tratamiento con lopinavir- ritonavir en pacientes del programa de infección por VIH en un hospital universitario, Bogotá, Colombia Experience with lopinavir/ritonavir for patients with HIV infection at an university hospital in Bogotá, Colombia

Resumen La terapia antirretroviral con varios medicamentosde diferentes familias es altamente efectiva paracontrolar la replicacion viral y mejorar la respuestainmunologica y las posibilidades de supervivencia enlos pacientes infectados por el VIH. Objetivos. Evaluar la eficacia del tratamientode rescate con lopinavir/ritonavir en una cohorte depacientes en un pais subdesarrollado. Materiales y metodos. Se hizo una revisionretrospectiva de los pacientes que recibieron trata-miento antirretroviral con la combinacion delopinavir/ritonavir en el Hospital Universitario de SanIgnacio. Se seleccionaron los pacientes del progra-ma integral de atencion a pacientes con infeccionpor VIH y se evaluaron la respuesta virologica e in-munologica, la tolerancia y el cumplimiento de laterapia. Resultados. Veinticinco pacientes con trata-miento anitrretroviral previo y un paciente con tra-tamiento por primera vez tuvieron un seguimientopromedio de 13 meses, con medicion de la cargaviral y recuento de CD4. El promedio de esquemasantirretrovirales utilizados fue de 2,28. El recuentode CD4 se elevo significativamente y ninguno de lospacientes con seguimiento de 36 meses tuvo recuen-tos de CD4 menores a 50 por mililitro. El porcentajede pacientes con carga viral indetectable (<100 co-pias) fue de 75% posterior al inicio del medicamento.
Do thickened feeds improve outcomes in healthy term newborns with reflux?

Healthy newborns with gastroesophageal reflux given thickened feeds have two fewer episodes of regurgitation per day and are 2.5 times more likely to have resolution of symptoms at short-term follow-up (number needed to treat55) than nonthickened formula–fed babies (SOR B: meta-analysis of lower quality randomized controlled trials). Feed thickeners should be trialed before initiation of acid-suppressive medications and before use of extensively hydrolyzed protein or amino acid formula (SOR C: multisocietal consensus statement). Copyright © 2019 by Family Physicians Inquiries Network, Inc. DOI 10.1097/EBP.0000000000000602
PoI: uma Aplicação de Detecção de Pontos de Interesse

With the emergence of social networks such as Twitter, Instagram and Foursquare, there was also the introduction of the concept of Participatory Sensor Networks (PSNs). Through this type of sensing, it is possible to collect general information of a particular location, using data provided by users and their mobile devices. Based on a data set of 333,286 check-ins, we present an application that uses Foursquare data to provide the Points of Interest (PoI) in Brazilian capitals, in other words, the most frequented venues, based on the number of check-ins. The aim is to provide the necessary information for tourism and advertising campaigns. Resumo. Com o surgimento de redes sociais, como o Twitter, o Instagram e o Foursquare, houve também a introdução do conceito de Redes de Sensores Participativas (RSPs). Através deste tipo de sensoriamento, é possı́vel coletar informações gerais de uma determinada localidade, utilizando dados disponibilizados por usuários e seus dispositivos móveis. Baseado em um conjunto de dados de 333.286 check-ins, apresentamos uma aplicação que, através de dados do Foursquare, fornece os Pontos de Interesse em capitais brasileiras, ou seja, os locais mais frequentados, baseado no número de check-ins do local. O objetivo é prover as informações necessárias para o turismo e para campanhas publicitárias. 1. Introdução Com a evolução dos celulares, hoje chamados de smartphones, tornou-se possı́vel a detecção de dados relacionados aos usuários, como as suas opniões e sua localização [Silva et al. 2014]. A introdução de sensores como GPS, acelerômetro, microfone, câmera e giroscópio nestes dispositivos [Lane et al. 2010], permitiu o sensoriamento de diversas áreas, em sua maioria urbanas. Esta rede de sensores, composta por todos os integrantes de uma sociedade que possuem dispositivos móveis, é denominda Rede de Sensores Participativa [Silva et al. 2013a]. Nas Redes de Sensores Participativas (RSPs), os usuários são entidades móveis autônomas capazes de sensoriar todo o ambiente no qual estão inseridos [Silva et al. 2014]. Assim, é possı́vel adquirir informações relacionadas a uma determinada localidade através de dados de redes sociais e de dispositivos móveis utilizados por estes usuários.
Detection of Myocardial Injury Using miRNAs Expression as Genetic Biomarkers in Acute Cardiac Care

Abstract Cardiovascular disease is a leading cause of death globally. At present, there are many ways to diagnose this pathophysiology. The greatest disadvantages related to current biomarkers are their low specificity, low selectivity and low accuracy. A new method, extensively studied recently, is the expression of miRNAs, used as genetic biomarkers for the early diagnosis of cardiovascular diseases. This paper presents an update of miRNAs species expression that can serve as early diagnostic biomarkers and for the continuous monitoring of patients with cardiovascular disease.
BEAM Versus CEB Conditioning for Autologous Transplantation in Patients with Non-Hodgkin’s Lymphoma and Hodgkin’s Disease: A Single Center Comparative Study of 219 Patients.

High-dose chemotherapy (HDC) with autologous stem-cell support (ASCS) is commonly used to treat patients with relapsed or high risk but chemosensitive non-Hodgkin’s lymphoma (NHL) and Hodgkin’s Disease (HD). However, the optimum HDC regimen for these patients has not been defined. CEB or BEAM are among the most commonly used regimens, but they have not been compared in a randomized prospective study. At our center, CEB was the preferred regimen until Dec 2002 and BEAM has been the preferred regimen since. We compared pre-treatment characteristics and post HDC outcomes in 219 consecutive patients undergoing single HDC+ASCS for NHL/HD at our center who received BEAM or CEB as the HDC regimen. BEAM (BCNU 300mg/m2, Etoposide 800 mg/m2, Cytarabine 1600 mg/m2, Melphalan 140 mg/m2) was used in 110 patients and 109 patients received CEB (Cyclophosphamide 6000mg/m2, Etoposide 2000mg/m2, BCNU 600mg/m2). The groups were comparable with respect to pre-treatment characteristics: median age (48 vs 52), gender (M 66% vs 64%), diagnosis (NHL 75% vs 81%), number of prior regimens (median=2 for both),stage at diagnosis, disease status pre-HDC, and median CD34+ cell dose/kg infused (5.6 x 10e6 vs 5.4x 10e6), KPS (≥90 vs Estimated Kaplan-Meier probabilities of progression-free survival (PFS) at 12 months and 24 months post HDC were 66.3%, 49.3% for BEAM and 60.2%, 55.1% for CEB (p=NS). The probability of overall survival (OS) at 12 and 24 months was 79.2%, 68.7% respectively for BEAM and 68.6%, 62.9% for CEB (p=NS). Transplant-related mortality (TRM) at 12m was 4.5% for BEAM versus 6.4% for CEB (p=NS). A Cox proportional hazards analysis was performed to assess the effect on OS, PFS and TRM of the following variables: regimen (BEAM vs CEB), diagnosis (HD vs NHL), age, gender, KPS, number of prior Rx regimens,stage at diagnosis, stage at treatment, disease status at transplant, CD34+ cell dose. On multivariate analysis, the following statisically significant associations were observed for the three outcome variables. PFS: age, gender, number of prior regimens,disease status at transplant. OS: age, gender, diagnosis, disease status at transplant. TRM: none. Females and patients with HD had better OS and PFS than males and NHL patients respectively. Conditioning regimen did not correlate with outcome for PFS, OS or TRM.The rate of severe mucositis (as defined by use of infusional opiate therapy during the first 25 days following HDC+ASCS) was significantly higher with CEB than BEAM (53% vs 47%, p=0.040). The rate of BCNU induced pnemonitis syndrome (as measured by prednisone use during first 30–120 days following HDC+ASCS and/or hospital readmission before day +120) was not significantly different between the two regimen groups. In summary, analysis of this sequential series of well matched patients receiving BEAM or CEB for HDC+ASCS for NHL or HD indicates that survival outcomes are comparable and BEAM is associated with a significant lower incidence of mucositis
Probing the Dark Universe with Gravitational Waves

Gravitational wave (GW) astronomy opens new opportunities to explore the universe and its fundamental laws. This thesis focuses on probing the pillars of the standard cosmological model with GWs, specially its most puzzling components: dark energy (DE) and dark matter (DM). We propose and apply new tests of DE and General Relativity (GR) with the propagation of GWs. We also investigate the formation of black-holes (BHs) in the early universe, which has strong implications on their contribution to the DM and on their GW signatures. Just as electromagnetic radiation can scan materials, GWs can probe the medium in which they propagate. DE models beyond Einstein’s gravity generically modify the propagation of GWs. We identify the speed of GWs as a key test of gravity and find the conditions for an anomalous speed to arise. We emphasis that a non-luminal speed can appear in cosmological models aiming at DE such as Galileons, but also in environments with a spatial profile induced by screening or scalar hair. After the multi-messenger event GW170817, we determine the consequences of the tight constraint on the speed of GWs for different classes of gravity theories and DE models, setting the dead ends and the road ahead. Standard sirens like GW170817 constrain as well the GW luminosity distance. We derive this observable in general theories of gravity and discuss its detectability with the future space-based detector LISA. Particularly distinguishable oscillatory patters are produced by GW oscillations, a phenomenon that we study in detail. Other probes of GW oscillations are modified wave-forms, induced anomalous speeds and polarization dependent signals. Primordial BHs (PBHs) could be a unique relic to unveil the physics of the early universe. We study the production of PBHs in single field model of inflation with a quasi-inflection point, showing the growth of perturbations beyond slow-roll (SR) at sub- and super-horizon scales. We propose a particle physics motivated model, critical Higgs inflation, achieving a copious PBH production with several GW signatures. However, when curvature fluctuations are enhanced, quantum diffusion dominates the classical inflationary dynamics. We develop a formalism based on stochastic inflation beyond SR to account for this effect. We encounter that the classical prediction is importantly modified, with relevant non-Gaussian contributions. To quantify better the quantum correction, we devise a method to compute directly the tail of the curvature perturbation distributions. As a first step, we apply it to SR inflation. We conclude that the abundance of PBHs is many orders of magnitude larger than the Gaussian prediction, discussing its implications for inflationary model building as well as for the GW observables. Altogether, GW astronomy stands as a powerful channel to advance forward in the quest for understanding the dark universe. We discuss the future prospects of this line of research, highlighting the theoretical challenges and observational opportunities that next generation GW detectors will provide.
Chemical Composition, Mineral Profile and Sensory Properties of Traditional Cheese Varieties in selected areas of Eastern Gojjam, Ethiopia

This study was conducted to evaluate the chemical composition, mineral profile and sensory properties of Metata, Ayib and Hazo traditional cheese varieties in selected areas of Eastern Gojjam. The chemical composition and mineral content of the cheese varieties were analyzed following standard procedures. Sensory analysis was also conducted by consumer panelists to assess taste, aroma, color, texture and overall acceptability of these traditional cheese varieties. Metata cheese samples had significantly (P<0.05) lower moisture content and higher titratable acidity than Ayib and Hazo cheese samples. The protein, ash, fat contents of Metata cheese samples were significantly (P<0.05) higher than Ayib and Hazo cheese samples. Moreover, phosphorus, calcium, magnesium, sodium and potassium contents of Metata cheese samples were significantly (P<0.05) higher than that of Ayib and Hazo cheese samples. Metata cheese samples had also the highest consumer acceptability scores compared to Ayib and Hazo cheese samples. In general, the results of this work showed that Metata cheese has higher nutritional value and overall sensory acceptability. This could be due to the fermentation of the product for several months and use of different types of spices.