Miracle-dz/UniFAR-FTUs huggingface dataset:
ESTRATÉGIAS NUTRICIONAIS PARA MANIPULAÇÃO DA CONCENTRAÇÃO DE COLESTEROL NO OVO DE POEDEIRAS COMERCIAIS

Durante decadas o colesterol foi associado a doencas vasculares e cardiopatias, sendo por inumeras vezes contraindicado o seu consumo, e consequentemente o ovo. Visando impulsionar o aumento no consumo per capita de ovos, inumeras pesquisas foram conduzidas com o objetivo de reduzir a concentracao de colesterol na gema do ovo de poedeiras comerciais, a partir de manipulacoes dieteticas de galinhas e codornas. Os resultados obtidos se mostraram eficientes em diversas estrategias tais como carvao vegetal, fontes de oleos, compostos fenolicos etc. Entretanto, mecanismos fisiologicos adaptativos impedem que as aves mantenham as concentracoes de colesterol reduzidas permanentemente. Objetivou-se com esta revisao discutir resultados de protocolos cientificos conduzidos para reduzir a concentracao de colesterol na gema do ovo de poedeiras.
The association among teacher-student relationship, subjective well-being, and academic achievement: Evidence from Chinese fourth graders and eighth graders

This study compared the teacher-student relationship, subjective well-being, and academic achievement between fourth graders and eighth graders, and examined whether and how subjective well-being played a mediating role concerning teacher-student relationship and academic achievement across the two grades. The participants included 19,845 fourth graders and 11,691 eighth graders from a city in central China. The findings indicated that (1) compared with eighth graders, fourth graders reported significantly higher mean scores in the teacher-student relationship, subjective well-being, and academic achievements; (2) a positive teacher-student relationship can promote students’ academic achievement both directly and indirectly through subjective well-being across the two groups; (3) The mediating effect of subjective well-being accounted for 42.8% of the total effects between teacher-student relationship and academic achievement for fourth graders, which was higher than that for eighth graders (22.7%). Limitations and future directions are elaborated.
Life in plastic, it’s fantastic! How Leishmania exploit genome instability to shape gene expression

Leishmania are kinetoplastid pathogens that cause leishmaniasis, a debilitating and potentially life-threatening infection if untreated. Unusually, Leishmania regulate their gene expression largely post-transcriptionally due to the arrangement of their coding genes into polycistronic transcription units that may contain 100s of functionally unrelated genes. Yet, Leishmania are capable of rapid and responsive changes in gene expression to challenging environments, often instead correlating with dynamic changes in their genome composition, ranging from chromosome and gene copy number variations to the generation of extrachromosomal DNA and the accumulation of point mutations. Typically, such events indicate genome instability in other eukaryotes, coinciding with genetic abnormalities, but for Leishmania, exploiting these products of genome instability can provide selectable substrates to catalyse necessary gene expression changes by modifying gene copy number. Unorthodox DNA replication, DNA repair, replication stress factors and DNA repeats are recognised in Leishmania as contributors to this intrinsic instability, but how Leishmania regulate genome plasticity to enhance fitness whilst limiting toxic under- or over-expression of co-amplified and co-transcribed genes is unclear. Herein, we focus on fresh, and detailed insights that improve our understanding of genome plasticity in Leishmania. Furthermore, we discuss emerging models and factors that potentially circumvent regulatory issues arising from polycistronic transcription. Lastly, we highlight key gaps in our understanding of Leishmania genome plasticity and discuss future studies to define, in higher resolution, these complex regulatory interactions.
A 2023 update on the performance of ionic-liquid proton-exchange-membrane fuel cells

A mini-review is provided of the literature concerning the performance of proton-exchange-membrane fuel cells (PEMFCs) containing (immobilized) ionic liquids as possible electrolytes, focusing on papers reporting performance metrics (power and current densities). For over a decade, and especially for combined heat and power applications, there has been a drive to design an ionic-liquid-holding membrane that could operate well under non-humidifying (water-free) conditions above 100°C. Such a goal has not yet been achieved: reported power densities are still below those of traditional low-temperature fuel cells. Other recent reviews have already pointed to three main issues: poor conductivity, poor cathode (oxygen-reduction) kinetics, and seepage of the liquid from the membrane. In this review, IL-PEMFCs are grouped into three IL classes (protic, aprotic, and polymerized), performance metric data are summarized, the cases producing the top ten peak power densities of the last 5 years are discussed, and the conductivity mechanisms of the leading cases are elucidated. Purely vehicular protic ILs appear to be too slow, and the trend toward enhanced Grotthuss H+ relays via polymerized ILs is revealed.
Conservative Management of Placenta Accreta of Seven Cases

Introduction: Placenta accreta is a potentially life threatening obstetrical condition. The incidence has increased. Diagnosis before delivery allows multidisciplinary planning in an attempt to minimize potential maternal or neonatal morbidity and mortality. Prenatal ultrasonography is used to support the diagnosis and guide clinical management leading probably to favorable outcomes. Actually a conservative option which includes leaving all or part of the placenta in situ when fertility preservation is desired is recommended. Methods: We retrospectively reviewed the medical records of all patients diagnosed with placenta accreta in gynecology-obstetrics department of the university hospital Mohammed the VI of Marrakesh; Morocco; from January the first 2014 to January the second 2016. Results: We found seven cases. We described: The epidemiological characteristics, risk factors, management of placenta accreta, outcomes and prognosis. The incidence of placenta accreta was 1/3847 deliveries. The mean term of delivery was 35 weeks. We have adopted a successful conservative treatment in six cases (71.4%). The radical treatment was adopted in one patient initially admitted for severe post-partum hemorrhage; the prognosis was good in 85.7% cases. Conclusion: Conservative management of placenta accreta is a safe and efficient and is an interesting alternative for hysterectomy.
Circadian Variation of Paroxysmal Atrial Fibrillation

Background Circadian variation in the incidence of acute cardiovascular events is well known but has not been extensively investigated in paroxysmal atrial fibrillation, although the significance of this arrhythmia is growing in our society with the increasing number of aged people. Methods and Results We detected 150 patients with paroxysmal atrial fibrillation in a drug-free state from among 25 500 consecutive Holter recordings. To determine whether the onset, maintenance, and termination of paroxysmal atrial fibrillation were random events, we analyzed the total recorded duration of arrhythmia and the incidence of and number of patients with the onset, maintenance, and termination of this arrhythmia as hourly data and as hourly probabilities. A prominent circadian rhythm of the total duration of atrial fibrillation, ≈90% of which was well explained by a single cosinusoidal function, was detected with a nadir around 11 am. Because the onset of the arrhythmia had little or no circadian rhythm, this findi.
What Is the Role of Work-Related Factors in Self-Reported Health Inequalities among Employed Individuals? A Longitudinal Study in Luxembourg

Objectives: We measured health inequalities among employed Luxembourg residents over time and the socio-economic and work-related determinants. Design and Setting: Longitudinal data were obtained from the Socio-economic Liewen zu Letzebuerg/European Union Survey on Income and Living Conditions, which has been conducted each year since 2003 in Luxembourg. Participants: Participants comprised 727 Luxembourg residents (58% men), aged between 21 and 55 years in 2003, who were employed between 2003 and 2012. Primary and Secondary Outcomes Measured: The variable of interest was self-reported health. We used transition indicators on work-related factors to consider changes that individuals may have experienced in their job over this period. Results: People who moved from a part-time to a full-time contract (odds ratio (OR): 5.52, confidence interval (CI): 1.55 - 19.73), and those who moved from the 3rd or 4th quartile of earnings to the 1st or 2nd quartile (OR: 2.48, CI: 1.02 - 6.05) between 2003 and 2012, had a higher risk of being in poor health in 2012. The risk of deterioration in self-reported health in 2012 among people who were healthy in 2003 was associated with the type of contract, economic activity, and occupation. Conclusion: Health inequalities occur among employed people in Luxembourg. Their importance varies according to work-related characteristics and economic activity. Our findings showed that declined health status was associated with contract type, profession, and economic activity. This suggests that measures should be taken to maintain good health for people working in these specific occupations or economic sectors (e.g. preventive action, reduction of risk exposure, change of occupation in the same company, and so on).
Regulation of Fibrillar Collagen Gene Expression and Protein Accumulation in Volume-Overloaded Cardiac Hypertrophy

Background Interstitial collagen accumulation has been extensively demonstrated to be increased at both mRNA and protein levels in pressure-overloaded cardiac hypertrophy. However, few data are available regarding the effects of volume overload on myocardial collagens. Methods and Results To determine whether the alterations of collagens may occur in volume-overloaded cardiac hypertrophy, we measured collagen types I and III mRNA levels and protein accumulation in left ventricular (LV) myocardium of rats at 3, 7, and 28 days after the creation of an aortocaval (AC) shunt. Eccentric LV hypertrophy was produced in rats with AC shunting. Northern blot analysis on RNA extracted from LV tissue indicated that the steady state mRNA levels for both type I and III collagen were persistently upregulated in AC shunt rats compared with sham-operated control rats. In contrast, the biochemical collagen protein concentration and morphometric collagen volume fraction were comparable between sham-operated control and AC s.
Zlomeniny talu. Současný pohled z hlediska diagnostiky, léčby a výsledků

The talus is the key articular segment linking the leg and foot, and as such, is subject to complex loads and may occasionally fracture. Fracture patterns provide clues to the underlying pathomechanics and energy of the injury, both of which can help guide treatment and suggest prognosis. Talus fractures have a wide variety of presentation from low-energy avulsion fractures of the lateral or posterior processes, to high-energy comminuted talar body fractures. Appropriate, expedient treatment provides the patient the best chance of obtaining a good functional outcome. Treatment relies on appropriate diagnosis, which hinges on clinical suspicion provided by the patient's account of pathomechanics, clinical examination, and radiological workup. This current concepts review discusses the pathomechanics, presentation, workup, treatment, and prognosis of fractures of the talar head, neck, body, lateral process, posterior process, and talar extrusions.
Molecular Biology

Recent advances in molecular biology techniques permit scientists to identify genetic contributions to alcoholism. Two main types of technology are commonly used to identify genes that cause or predispose a person to a disease: positional cloning techniques and candidate gene techniques. Positional cloning techniques allow disease genes to be identified based solely on their location within the genome without prior knowledge of the gene’s function. Techniques for confirming the role of candidate genes rely on sufficient prior understanding of the disease process to implicate possible disease-related genes. Scientists use cloning techniques or the application of certain enzymes to reproduce a candidate gene in sufficient quantity for study. As the human genome project progresses and the gene map becomes increasingly complete, more and more disease genes will be identified through a combination of positional cloning and the candidate gene approach.
A Randomized Clinical Trial Comparing the Effects of Diode Laser and Diode Laser along with Topical Application of Glutathione as an Adjunct in the Management of Gingival Hyperpigmentation

Background: Pigmentation of the gingiva is a negative factor in an otherwise acceptable “smile window”. Recently, cryosurgery and laser techniques have gained popularity for depigmentation and seem to be the most reliable and satisfactory procedures. To our knowledge, this study is unique and is the first reporting comparison of diode laser and lasers along with topical application of glutathione in the literature.
Pregnancy outcome in South Australia: Population and cohort studies

Adverse pregnancy outcome, including preterm birth, small for gestational age, gestational diabetes mellitus and hypertensive disorders of pregnancy affect a quarter of first pregnancies, but their pathophysiology is not fully understood. The studies presented in this thesis describe long-term trends, sexual dimorphism, seasonality of these adverse pregnancy outcome and maternal haemodynamics in pregnancy in South Australia. - In many Western countries, such as (South) Australia, the preterm birth rate has increased, mostly due to increased iatrogenic delivery, particularly in pregnancies complicated by hypertensive disorders of pregnancy, small for gestational age, and preterm prelabour rupture of the membranes. This was also seen in South Australia. However, overall and preterm stillbirth rates have declined. - Fetal sex is an independent risk factor for adverse pregnancy outcome. A male disadvantage is observed in most but not all adverse pregnancy outcomes. - The incidence of gestational diabetes mellitus and hypertensive disorders of pregnancy in South Australia showed seasonality. Winter conceptions had higher gestational diabetes mellitus rates, while gestational diabetes mellitus rates were the lowest for summer conceptions. Meanwhile, spring conceptions had higher hypertensive disorders of pregnancy rates, while hypertensive disorders of pregnancy rates were the lowest for autumn conceptions. New perspectives in exposures with these conditions can be sought in periodicity. - Maternal haemodynamic maladaptation to pregnancy differs between subtypes of hypertensive disorders of pregnancy, indicating a different pathophysiology between these subtypes. Being intermittent hypertensive in pregnancy is not benign. Monitoring haemoynamic adaptation throughout pregnancy could potentially identify women at risk for hypertensive disorders of pregnancy.
Hibernom – ein seltener Weichteiltumor

Zusammenfassung Hibernome sind seltene benigne, von braunem Fettgewebe differenzierte Tumoren. Sie treten hauptsächlich in der dritten bis fünften Lebensdekade bei vermutlich leichter Bevorzugung des männlichen Geschlechts auf. Die am häufigsten betroffene anatomische Lokalisation ist der Oberschenkel gefolgt von Schulter, Rücken und Hals. Die in der Regel asymptomatischen Tumoren werden oft als Zufallsbefund entdeckt und gewinnen oft erst durch ihre kontinuierliche Größenzunahme klinische Bedeutung. Histologisch unterscheidet man vier morphologische Formen: die typische Variante mit Subtypen, die myxoide, die lipomähnliche und die spindelzellige Variante. Die kernspintomografische Diagnostik zeigt charakteristische aber nicht spezifische Merkmale, so dass die abschließende Diagnosesicherung durch eine histologische Begutachtung zu stellen ist. Vereinzelt sind lokale Rezidive nach intraläsionaler Resektion beschrieben. Für den Fall einer sicheren marginalen Resektion bestehen diese Bedenken nicht, so dieses Vorgehen bei gegebener operativer Indikation zu empfehlen ist. Bislang existieren in der Literatur keine Hinweise auf eine eingetretene Metastasierung durch ein Hibernom.
Biological processes related to positive development after preterm birth: the interplay between sleep, hypothalamic-pituitary-adrenal axis activity, and autonomic functioning, and the role of parental insomnia symptoms

Biological processes, including sleep, the hypothalamic-pituitary-adrenocortical (HPA) axis, and the autonomic nervous system (ANS), play an important role in positive development across the life-span. They are highly susceptible to early life experiences such as very preterm (VP) birth and to concurrent environmental factors such as parental sleep. Yet, research examining sleep, HPA axis activity, and ANS functioning in children and adolescents is rare. Therefore, the goal of this cumulative dissertation containing three studies is (a) to extend knowledge of the interplay between sleep, HPA axis activity, and ANS functioning during childhood and adolescence, (b) to examine the role of VP birth in these biological processes, and (c) to test whether parental insomnia symptoms are related to their children’s sleep as well as to parental perception of children’s sleep-related behavior. The samples included in the studies of this dissertation derived from the second wave of the Basel Study of Preterm Children investigating VP and full-term (FT) children and adolescents. Findings from Study 1 (Maurer et al., 2016) showed an association between elevated post-awakening HPA axis activity and a later sleep onset time, shorter sleep duration, and shorter rapid eye movement latency across the whole sample. Additionally, Study 2 (Urfer-Maurer et al., 2018) showed that predominant sympathetic activity of the ANS at rest and during different sleep stages was related to increased post-awakening HPA axis activity across the whole sample. Further, Study 1 showed that VP children had an earlier sleep onset time and lower HPA axis activity compared to FT children. Mediation analyses showed that earlier sleep onset time partially accounted for lower post-awakening HPA axis activity in VP children. Moreover, Study 2 showed that VP children had a dominance of parasympathetic over sympathetic activity of the ANS when awake and during stage 2 sleep. The results of Study 3 (Urfer-Maurer et al., 2017) revealed that maternal but not paternal insomnia symptoms were related to less restorative sleep in children. Finally, parental insomnia symptoms were related to parents’ reports of their children’s sleep-related behavior, and maternal insomnia symptoms were additionally related to paternal reports of sleep-related behavior in children. Findings of the present dissertation highlight the important role VP birth plays in altered development of biological processes, especially HPA axis activity during childhood and adolescence. Additionally, they emphasize that parental sleep difficulties may affect the sleep of their own children as well as how they perceive their children’s sleep. This dissertation outlines the practical implications of these results for the design of new treatments to foster positive development associated with sleep, HPA axis activity, and ANS functioning.
Durable response with venetoclax in combination with decitabine or azacitadine in elderly patients with acute myeloid leukemia (AML).

7010Background: Venetoclax (VEN), an oral BCL-2 inhibitor, has synergistic activity when combined with hypomethylating agents. This clinical study explores the optimal dose and efficacy of VEN in combination with decitabine (DEC) or azacitadine (AZA) in elderly AML. Methods: This is an open-label, phase 1b, dose escalation and expansion study (NCT02203773) on the safety and efficacy of VEN, with DEC or AZA, in elderly patients (≥65 years) with untreated AML. VEN was coadministered daily with 20 mg/m2 of DEC on days 1-5 or 75 mg/m2 of AZA on days 1-7, each 28 day cycle. VEN was dosed at 400, 800, or 1200 mg in the escalation phase, and 400 or 800 mg in the expansion phase. Complete remission (CR), CR with incomplete blood count recovery (CRi), overall survival (OS) and adverse events (AEs) were evaluated. Results: Data cutoff was July 7, 2017. Of 145 patients, 56% were male; the median age was 74 years (range: 65–86). Overall, 60, 74, and 11 patients received VEN at 400, 800, and 1200 mg, respectively. Key.
Letter by Benedict et al regarding article, "What causes disability after transient ischemic attack and minor stroke? Results from the CT and MRI in the Triage of TIA and minor cerebrovascular events to identify high-risk patients (CATCH) study".

To the Editor: Coutts et al1 report on the importance of computed tomography (CT) brain/CT angiography (CTA) as valuable imaging techniques in the assessment of minor stroke and transient ischemic attack (TIA). They show that patients with abnormalities on the CT/CTA metric were at high risk for disability, even in the absence of a recurrent event. We write to support their finding and present our data obtained from a COMmunity-Based rapid-Access TIA (COMBAT) clinic. CTA offers a number of advantages, such as the possibility of morphological assessment of cerebral blood vessels, including site and length of occluded segments, and assists in selection of treatment for patients with TIA.2 It can also be interpreted relatively rapidly by radiologists and is generally more available than MRI, which has limited availability outside specialist units.3, …
Tratamiento farmacológico y génico en las distrofias musculares de Duchenne y Becker

Introduccion: Las distrofias musculares son las enfermedades degenerativas mas comunes dentro de las enfermedades neuromusculares, cursan con debilidad muscular que progresa hasta la perdida de la deambulacion y en la segunda decada de vida surgen complicaciones cardiacas, respiratorias y ortopedicas. Objetivo: Conocer el estado actual de los tratamientos genico y farmacologico en las distrofias musculares de Duchenne y Becker. Metodos: Se realizo una busqueda en los meses de enero, febrero y marzo de 2018 en las bases de datos Medline, Cinhal, Web Of Science y Scopus. Se obtuvieron 232 resultados y despues de aplicar los criterios de inclusion y exclusion, se consiguieron para analizar 15 articulos validos para la revision. Resultados: Los articulos analizados investigan mayoritariamente el efecto de las terapias mencionadas a nivel de funcionalidad y de sintesis de la proteina distrofina durante periodos largos, en los que participan muestras de tamano y edades variadas tanto como distrofia muscular de Duchenne y como distrofia muscular de Becker. Conclusiones: Existen mas articulos enfocados en la distrofia muscular de Duchenne que en la distrofia muscular de Becker. Esto puede ser debido a que la primera es la mas grave y de peor pronostico. Sigue siendo necesario realizar mas estudios para avanzar sobre el estado actual de estos tratamientos.