Miracle-dz/UniFAR-FTUs huggingface dataset:
Ukraine Data on Prognostic Factors and Treatment Outcomes in Patients with Peripheral T-Cell Lymphomas.

BACKGROUND Peripheral T-cell lymphomas (PTCLs) is a diverse group of lymphomas (10-15% of all non-Hodgkins lymphomas) with aggressive behavior. Despite the standard of 1st line anthracycline-containing regimens, clinical outcomes are poor compared to B-cell lymphomas. In addition, there are still debates about specific prognostic factors (PF) in PTCLs. AIMS Primary endpoints - event-free survival (EFS) and overall survival (OS). To evaluate the prognostic significance of five PTCLs scores (International Prognostic Index - IPI, International Peripheral T-cell lymphoma Project Score - IPTCL, Prognostic Index for T-cell lymphoma - PIT, modified Prognostic Index for T-cell lymphoma - mPIT and T-cell score). PATIENTS AND METHODS From 67 enrolled patients, only 50 were included: PTCL not otherwise specified (22, 44%), anaplastic large cell lymphoma ALK+ (anaplastic lymphoma kinase-positive) (10, 20%) and ALK (anaplastic lymphoma kinase-negative) (18, 36%). Patients received CHOP-like regimens (CHOP, CHOEP, EPOCH). RESULTS The overall rate response was observed in 66% of cases (complete response 78%). There were 48% of relapses after the 1st line therapy during follow-up (median 11 months; range 1-85 months). Median age 57 (range 22-80) with male predominance 62%. In total, 40% of patients were > 60 years old, 48% had stage III-IV. Majority of patients were assessed by five prognostic scores. IPI (45 patients): the 3-year EFS and OS were higher for IPI 1 vs. IPI > 2 (80 vs. 18% and 87 vs. 27%, respectively; p = 0.0002). Receiver operating characteristic analysis confirmed poor clinical outcome to patients with PF > 1 (Se = 88 %; Sp = 68 %; AUC = 0.7; p = 0.0081). IPTCLP (41 patients): the presence of PF = 1-2 showed EFS and OS reduction. A 3-year EFS rate for 1-2 PF was 25 vs. 70% for PF = 0 (p = 0.003). Thus, 3-year OS in patients with PF = 0 vs. PF = 1-2 was 100 vs. 20% (p = 0.0001). PIT (42 patients): better 3-year EFS and OS in patients with PF = 0 vs. PF = 1-3 (88 vs. 28% and 100 vs. 34%, respectively, p = 0.001). Patients with PF = 1-3 have a higher rate of relapses vs. PF = 0 (p = 0.0005 by Cox-test). mPIT (21 patients): no significant difference between PF and clinical outcomes. T-cell score (18 patients): higher survival rates with PF 2. More than 2 PF have an impact on EFS (p = 0.005). The 3-years OS in patients with PF 2 was 77 vs. 25% in cases with PF 3 (p = 0.001). CONCLUSION IPI, PIT, IPTCLP are still very useful in defining risk stratification. As to mPIT and T-cell score, more patients to evaluate their prognostication possibility are needed.
Hemolytische ziekte van de pasgeborene en irregulaire- bloedgroepantagonisme in Nederland: Prevalentie en morbiditeit [Haemolytic disease of the newborn and irregular blood group antagonism in the Netherlands: Prevalence and morbidity]

Objective. To inventory prevalence and morbidity of haemolytic disease of newborn caused by irregular anti-erythrocyte antibodies other than antirhesus-D. Design. Prospective registration study. Method. All paediatricians (n = 380) in general hospitals and contact persons (n = 79) in university hospitals were asked for monthly reports of clinical cases of haemolytic disease of newborn during 2 years (1996-1997). Results. Response was 97%. A total of 130 reports were received in two study years, 49 of which could not be confirmed as non-RhD-non-AB0 antagonism. In the group of which the transfusion history was known (n = 60), 29 pregnant women (48%) had received transfused blood at some time. Of the antibodies found, anti-c, anti-E and anti-K were the most frequent. The direct antiglobulin test was positive in 61 of the 81 cases, negative in to cases, while in 10 cases it was unknown or false-negative due to earlier intrauterine transfusions (in three neonates). The highest bilirubin levels recorded were 572, 559 and 520 μ/mol/l (all three with maternal anti-c antagonism). Therapeutic data were known concerning 80 of the 81 newborn: 21 (16%) received no treatment, 24 (29%) only phototherapy and the others - in addition to phototherapy if any also blood transfusion, exchange transfusion or intrauterine transfusion, or a combination of these. Conclusion. It was calculated that the actual prevalence of irregular anti-erythrocyte antibodies in Dutch pregnant women probably amounts to approximately 0.25%. This finding may possibly be confirmed since starting 1 July 1998 all pregnant women in the country are screened for the presence of these antibodies. It is recommended that girls and women in the reproductive age group should receive primary prevention of development of irregular anti-erythrocyte antibodies by application of a selective blood transfusion policy, taking into account the occurrence of the antigens c, E and K. Chemicals/CAS: Isoantibodies; Kell Blood-Group System; Rh-Hr Blood-Group System
REEB GRAPHS OF SURFACES ARE STABLE UNDER FUNCTION PERTURBATIONS

Reeb graphs are combinatorial signatures that capture shap pro erties from the perspective of a chosen function. One of the most important questions is whether Reeb graphs are robust against function perturbations that may occur because of noise and approximation errors in the data acquisition process. In thi s work we tackle the problem of stability providing an editing distance between Reeb graph s of orientable surfaces in terms of the cost necessary to transform one graph into another by e dit operations. Our main result is that changes in the functions, measured by the maximum nor , imply not greater changes in this distance, yielding the stability property u nder function perturbations.
NDT_A_209700 2325..2338

Jessica Madera Pedro Such Peter Zhang Ross A Baker Iria Grande 1Medical Affairs, Otsuka Pharmaceutical Development and Commercialization Inc, Princeton, NJ, USA; 2Medical Affairs, H. Lundbeck A/S, Valby, Denmark; 3Bipolar and Depression Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain Purpose: There is growing agreement that definitions of “recovery” in bipolar-I disorder (BP-I) should include functional outcomes beyond sustained symptomatic remission. In this post-hoc analysis, we assessed functional recovery rates according to the validated Functioning Assessment Short Test (FAST) in participants with BP-I after 52 weeks of maintenance treatment with aripiprazole once monthly (AOM). Patients and methods: Rates of functional recovery with AOM 400 were investigated in two 52-week studies. NCT01567527 was a placebo-controlled, double-blind, randomized-withdrawal study and NCT01710709 was an open-label study. Functional recovery, assessed at the end of the respective maintenance phases, was defined as a total FAST score of ≤11 for 8 consecutive weeks. Results: Post-hoc analyses included 229 patients from the randomized-withdrawal study (AOM 400 n=116; placebo n=113). The open-label study included 402 patients (including 321 de novo patients and 81 rollover patients who had completed the randomized-withdrawal study). In the randomized-withdrawal study, functional recovery was achieved by 30.2% (n=35) of the AOM 400 group compared with 24.8% (n=28) in the placebo group. The difference was not statistically significant (p=0.39). In the open-label study, 36% (n=116) of de novo patients and 43% (n=35) of rollover patients had functionally recovered after 52 weeks of AOM 400 treatment. Conclusion: These data highlight the utility of a sustained FAST total score of ≤11 as a definition of recovery and emphasize the possibility of achieving this ambitious treatment goal with effective long-term treatment.
Polymorphic Variants of the Mitochondrial Cytochrome b gene (CYB) in the Ecuadorian population PAZ Y MIÑO C1, TAPIA A2, ARÉVALO M1, MUÑOZ MJ1, LLUMIPANTA W2, OLEAS

The mitochondrial genome is widely used in evolutionary and phylogenetic investigations of human populations, and its molecular information, obtained from the study of its genes, has become a valuable tool in the study of human migrations around the world, supporting available anthropological data. During this research, a segment of 560 pb of the CYB (cytochrome b) gene was analyzed through a PCR-SSCP test, to determine the polymorphic variability in 108 unrelated Ecuadorian individuals belonging to four ethnic groups (Mestizo, Native American, Afrcan-American and Cholos). We report the following variants and frequencies: G15043A (0.57), T15115C (0.06), C15040T (0.32) and A14926G (0.05). The obtained results contribute evidence of human migrations in the New World, and support existing anthropological data.
Effect of Zirconia and Alumina Nanofillers on the Microstructure and Some Properties of Flowable Composite

Purpose:studying the effect of reinforcing flowable composite with different concentrations of zirconia and alumina nanofillers on its microstructure, complex viscosity, colour changes, flexural strength and degree οf cοnversiοn. Materials and Methods:180 samples were divided according to nanofillers type into two groups(n=90),each group was subdivided into five subgroups according to concentration of fillers (0%,2%,4%,8%and16%)(n=20). Each group was subdivided into 4 subdivisions according to type of test performed(n=5). Samples were characterized by SEM, viscosity was measured by oscillatory rheοmeter, colour changes was measured using spectrophotometer, fǀexural strength was measured by three point bending test and degree of conversion was measured by FTΙR. Results: SEM showed homogenous distribution of zircοnia and alumina np at 2&4wt%, some agglomeration for both types of fillers at 8wt%. For complex viscosity, zirconia np at 16wt% at 25℃ had higher median value compared to 37℃ (6.17), Alumina np at 2wt% and 4wt% at 25℃ had higher median value compared to 37℃ (5.665),(8.516) respectively. For colour changes, zr& al np at 4wt% showed the highest mean values(10.2±1.5,11.1±1.4) respectively. Ιn flexural strength, zirconia filler at 4wt% had higher mean value (137.8±18.1MPa)compared to alumina filler(94.4±16.9 MPa). For DC, 4wt% for both zr& al np showed the highest mean values compared to other groups (66.4±2.4, 64.3±0.82) respectively.Conclusion: Viscosity increased as the concentration of nanofillers increased. Ιncorporation of nanofillers affect the cοlour of the flowable composite. Fǀexural strength was improved with increasing the concentration of zirconia nanofillers, while it decreased with alumina nanofillers. DC increased as the filler concentration increased till 4 wt. % then decreased.
Comparison of Crosslinker Types and Initiation Systems of Thermoresponsive PNIPAM Hydrogels

Thermoresponsive hydrogels are three-dimensional polymer networks which undergo conformational changes in aqueous media depending on the external temperature. As the lower critical temperature (LCST) is close to the body temperature, poly(N-isopropylacrylamide) (PNIPAM) is the main thermoresponsive hydrogel used for biomedical applications. Below LCST, PNIPAM hydrogels swell in aqueous media, above LCST they become insoluble and shrink. This behavior makes it possible to design drug release systems controlled by external temperature. Swelling/shrinking response of PNIPAM hydrogel depends on several factors such as crosslinker type, crosslinking density, hydrophobic/hydrophilic balance and initiator type. In this study, the effects of the initiation system and the crosslinker type on different thermoresponsive hydrogels were compared. For this purpose, thermoresponsive hydrogels were synthesized by using ethylene glycol dimethylacrylate (EGDMA) and N,N′-ethylene bisacrylamide (EBAM) as crosslinkers via photo and thermal initiation systems. The hydrogels were characterized by scanning electron microscope (SEM) and FTIR spectroscopy. Effects of the initiation system and the crosslinker type on the release, swelling behavior, morphology and the biocompatibility behavior of the hydrogels were investigated. The hydrogels synthesized with EBAM demonstrated more promising results compared to the one synthesized EGDMA. It was concluded that poly(EBAM-co-NIPAM)-P has the highest swelling ratio and poly(EBAM-co-NIPAM)-T is the most biocompatible hydrogel. In terms of release characteristics, there was not a significant difference between the hydrogels, even though their swelling characteristics differ.
Key factors in psychotherapy training: an analysis of trainers’, trainees’ and psychotherapists’ points of view

The literature on clinical training lacks identifications of the factors that are most relevant in training programs; accordingly, the main aim of this work is to fill this research gap by assessing which factors that trainers, trainees and psychotherapists consider most relevant in psychotherapy training programs. A secondary aim is to identify whether these factors differ among trainers, trainees and psychotherapists. An ad hoc questionnaire was created and administered at 24 psychotherapy schools from 14 institutions; the sample included 641 trainees, 172 trainers and 218 psychotherapists of various theoretical orientations. The questionnaire included 63 items and used a 5-point Likert scale. An exploratory factor analysis was completed to identify the latent structure. The reliability of the dimensions was then checked. Finally, an analysis of variance and a multivariate analysis of variance were completed to achieve the study’s aims. Four factors emerged from the study’s results: trainers’ relational characteristics, supervision, transmission of clinical know-how, and theoretical background and technical support. All these factors displayed acceptable reliability and internal consistency. Moreover, their relative rankings varied based on the participants’ roles and theoretical backgrounds. This study’s results indicate that the new instrument’s psychometric qualities are acceptable. It thus could be used to develop a new approach to psychotherapy training, as this study’s results regarding trainees’ needs underline the differences between trainees’ perceptions of those needs, as compared to trainers’ and psychotherapists’ perceptions.
Evolution and changes of tourism in Macedonia in the post-socialist period (1991–2018)

The study provides a historical and contextual analysis of the evolution of tourism in Macedonia. The time scope is defined as the period between 1991 and in 2018. The study investigates the tourism development in Macedonia in the post-socialist period of the country, using the Butler (1980) Tourist Area Life Cycle (TALC) model as an analytical tool. The model provides a framework to explain the complex processes of the development and changes in tourism in the country over the years. For this purpose, an analysis of secondary data sources is implemented to find the changes in the evolutionary stages of tourism development. The findings show that tourism in Macedonia is in a stage of development, and that it has not yet reached the consolidation stage. Lastly, the study offers a better understanding of how tourism in Macedonia is changing in the complex post-socialist period.
Tetracyclic triterpenoids from Euphorbia nicaeensis All

In this study, three tetracyclic triterpenes: (3S,24S)-tirucall-7-ene-3,24,25-triol (1), (3S,24R)-tirucall-7-ene-3,24,25-triol (2) and inoterpene C (3), were isolated from the milkweed Euphorbia nicaeensis All. using dry-column flash silica gel chromatography and semipreparative normal-phase HPLC. Their structures were determined on the basis of 1D and 2D NMR spectra and literature review. Although these three compounds have previously been isolated from other plant species, this is the first time that they have been isolated from E. nicaeensis.
Soft Factors of Economic Security1

The importance of economic security has increased considerably in the last decades. It can be separated into the following two parts: security of ordinary operation and security of long-term development. In this article we are going to be dealing with the latter, especially the so-called soft factors which make up the basis of it. These factors are the human capital, social capital and territorial capital. With the assistance of the tree model of competitiveness, we are going to demonstrate how important these factors are from the aspect of long-term economic development and social stability. Since the means of altering them is quite difficult and slow, developing them requires a continuous, well-considered, conscious strategy.
Gender Differences in Language Learning Strategies and Social Networking Use

Online Social Networks (OSNs) have become part and parcel of everyday communication among people. Many organizations and individuals have taken this opportunity to direct the use of social media for educational purposes. The current study investigates the use of OSNs, namely Facebook, Twitter, WhatsApp, Google+, and LinkedIn, on English learning. Specifically, the study focuses on the difference in use between males and females. Sixty Yemeni EFL learners participated in the study; 37 were females and 23 were males. The results reveal that both men and women have equal access to OSNs and perceive them as equally beneficial for their English skills. There was only one statistically significant difference concerning the frequency of using Facebook as men reported higher frequency of use than their female counterparts.
JOINT APPLICATION OF IEM AND RADIATIVE TRANSFERT FORMULATIONS FOR A BISTATICSCATTERING OF ROUGH SURFACES

Systematic characterization of scattering behavior of natural and manmade rough surfaces is required in many radar applications. The overall scattering response of such surfaces is composed of surface and volume scattering components. In this paper Integral Equation Method (IEM) is used to work out the surface scattering and Radiative transfer theory (RTT) is applied to model the volume scattering.
Comparison of Sitting Balance and Coordination in Children with Spastic Cerebral Palsy Using the Korean Version of Trunk Impairment Scale (K-TIS)

PURPOSE: The purpose of this study was to compare sitting balance and coordination spastic cerebral palsy in children using the Korean version of Trunk Impairment Scale (K-TIS) as well as to provide basic data about effective postural control treatment for clinicians handling these two types. METHODS: The K-TIS was measured in 29 children diagnosed with diplegic and quadriplegic cerebral palsy (18 with diplegia and 11 with quadriplegia). The average and standard scores of the children’s K-TIS subscales and items of the two groups were measured. The two groups’ subscales and items were analyzed by using the Mann-Whitney U test. RESULTS: Static sitting balance, dynamic sitting balance, coordination, and total score for children with diplegia were statistically high (p<.05). For all items under static sitting balance, the score for children with diplegia was higher. The
Global Warming and Changes in Sea Ice in the Greenland Sea: 1979-2007

This paper presents a statistical analysis of sea ice in the Greenland Sea (70-80N and 10W-10E) from January 1979 to December 2007. We define four variables from satellite images: ice extent, ice area, eastward ice extent at 75N, and the shape of the ice edge. We establish relationships between these ice variables and five climate variables: sea surface temperature (SST), air temperature at Jan Mayen Island (JM), sea surface pressure (SSP), North Atlantic Oscillation (NAO) and Arctic Oscillation (AO). The ice extent, ice area and eastward ice extent are highly correlated with SST and JM over the whole time period, while SSP, NAO and AO are only correlated with the ice variables over shorter (one year) periods. When considering the different shapes of the ice edge, an ANOVA model shows that 49% of the variance in extent can be explained by the shape of the ice edge, and similar amounts for the eastward ice extent and ice area. Fourier analysis of the sea ice data shows a 10 year peak which is consistent with previous hypotheses in work done on the Greenland Sea. Finally, we show that the negative trend in the sea ice extent, ice area and eastward extent is statistically significant. This can be interpreted as yet another indicator of the global warming that has been taking place for the last 30 years.
Wireless Sensor Networks: Lifetime Extension and Node Localization and its Potential Application in Agriculture

Wireless sensor networks have enabled great improvements on the development of several applications, such as agriculture. Through those networks we can have better monitoring and control over the conditions of a region and increase its plantation’s productivity. This work is driven to analyze some methods to locate and increase the lifetime of a sensor network having in mind its potential application in agriculture. Keywords—Wireless sensor networks, location algorithms, lifetime, agriculture.
Sentiment Analysis of Customers1

There is an economic and political need to learn and know more and more information about customers, and the social media has recently become the most powerful tool for interaction with people. Customers became users in the social media, who express their opinion and share it with not only companies but also other users. Since a huge amount of reviews, opinions and comments appeared, there is a necessity to extract, aggregate, and analyse them; these are the aims of sentiment analysis. In this paper the technological details of sentiment analysis are presented. The problem types and their solution with text mining are described. Text mining is based on data mining, but steps of text preprocessing with tokenisation, stemming, filtering is an additional important phase before the data mining procedure. The correctness of sentiment analysis solutions can be measured by different validation methods. At the end of the paper the final conclusion is presented.
Quantum integrability of N = 2 4d gauge theories

: We provide a description of the quantum integrable structure behind the Thermodynamic Bethe Ansatz (TBA)-like equation derived by Nekrasov and Shatashvili (NS) for N = 2 4d Super Yang-Mills (SYM) theories. In this regime of the background, | we shall show |, the instanton partition function is characterised by the solution of a TQ-equation. Exploiting a symmetry of the contour integrals expressing the partition function, we derive a ‘dual’ TQ-equation, sharing the same T-polynomial with the former. This fact allows us to evaluate to 1 the quantum Wronskian of two dual solutions (for Q ) and, then, to reproduce the NS TBA-like equation. The latter acquires interestingly the deep meaning of a known object in integrability theory, as its two second determinations give the usual non-linear integral equations (nlies) derived from the ‘dual’ Bethe Ansatz equations.