Miracle-dz/UniFAR-FTUs huggingface dataset:
The rationale, design, and implementation of the American Cancer Society's studies of cancer survivors

The American Cancer Society (ACS) defines cancer survivorship as beginning at diagnosis with cancer and continuing for the balance of life and views quality of life (QOL) as a key outcome. In this article, the authors describe the rationale, methodology, and sample characteristics of the 2 ACS Studies of Cancer Survivors (SCS): 1) a longitudinal study identifying and surveying survivors approximately 1 year postdiagnosis that includes plans to resurvey the panel at 2 years, 7 years, and 12 years postdiagnosis to identify predictors of QOL; and 2) a cross‐sectional study of QOL among 3 separate cohorts of survivors who were approximately 3 years, 6 years, and 11 years postdiagnosis at the time of data collection. Survivors of prostate, breast, lung, colorectal, bladder, skin, kidney, ovarian, and uterine cancers and of non‐Hodgkin lymphoma were sampled from 25 different central cancer registries, with African‐American and Hispanic survivors over sampled. Survivors completed either mail or telephone surveys that described their physical, psychological, social, and spiritual functioning. The overall recruitment rate was 34.0%; 15411 participants completed surveys, of whom 40.1% had a high school education or less and 19.4% were racial/ethnic minorities. The SCS surveys provide a large diagnostically, geographically, and demographically diverse database on cancer survivorship that was designed to overcome some of the limitations of past research. Future reports will compare QOL of survivors at different well‐defined times postdiagnosis, investigate the issues of understudied populations and diagnostic groups, and describe survivor QOL at state levels. Insights valuable to those considering registry‐based studies are offered on issues of ascertainment, sampling, and recruitment. Cancer 2007. © 2006 American Cancer Society.
Vascular effects dominate solid tumor response to treatment with combretastatin A‐4‐phosphate

Vascular‐targeted therapeutics are increasingly used in the clinic. However, less is known about the direct response of tumor cells to these agents. We have developed a combretastatin‐A‐4‐phosphate (CA4P) resistant variant of SW1222 human colorectal carcinoma cells to examine the relative importance of vascular versus tumor cell targeting in the ultimate treatment response. SW1222Res cells were generated through exposure of wild‐type cells (SW1222WT) to increasing CA4P concentrations in vitro. Increased resistance was confirmed through analyses of cell viability, apoptosis and multidrug‐resistance (MDR) protein expression. In vivo, comparative studies examined tumor cell necrosis, apoptosis, vessel morphology and functional vascular end‐points following treatment with CA4P (single 100 mg/kg dose). Tumor response to repeated CA4P dosing (50 mg/kg/day, 5 days/week for 2 weeks) was examined through growth measurement, and ultimate tumor cell survival was studied by ex vivo clonogenic assay. In vitro, SW1222Res cells showed reduced CA4P sensitivity, enhanced MDR protein expression and a reduced apoptotic index. In vivo, CA4P induced significantly lower apoptotic cell death in SW1222Res versus SW1222WT tumors indicating maintenance of resistance characteristics. However, CA4P‐induced tumor necrosis was equivalent in both lines. Similarly, rapid CA4P‐mediated vessel disruption and blood flow shut‐down were observed in both lines. Cell surviving fraction was comparable in the two tumor types following single dose CA4P and SW1222Res tumors were at least as sensitive as SW1222WT tumors to repeated dosing. Despite tumor cell resistance to CA4P, SW1222Res response in vivo was not impaired, strongly supporting the view that vascular damage dominates the therapeutic response to this agent.
Defeitos de parede abdominal fetal : resultados do Programa de Medicina Fetal do CAISM-UNICAMP em dez anos

Introducao: As malformacoes de parede abdominal fetal ocorrem entre a quinta e a decima semanas de idade gestacional, devido a falhas na sequencia normal do desenvolvimento embrionario. Costumam ser diagnosticadas precocemente com o uso da ultra-sonografia, geralmente por volta de doze semanas de gestacao. A gastrosquise e a onfalocele sao os defeitos mais comuns da parede abdominal. A gastrosquise, em geral, ocorre isoladamente, enquanto a onfalocele apresenta maior incidencia com o aumento da idade materna, e comumente associa-se a anomalias geneticas. A adequada assistencia em casos de malformacao de parede abdominal demanda experiencia do servico e conhecimento da historia natural da lesao. Objetivo: Avaliar a frequencia dos defeitos da parede abdominal fetal em gestantes atendidas no Ambulatorio de Medicina Fetal do CAISMUnicamp entre 1996 e 2006, alem de dados epidemiologicos e resultados neonatais. Sujeitos e Metodos: Foi realizado um estudo descritivo retrospectivo, atraves da revisao de prontuarios de gestantes com fetos acometidos por malformacoes da parede abdominal. Os dados foram analisados atraves de tabelas de frequencia. Resultados: A frequencia das malformacoes de parede abdominal fetal nas gestantes estudadas foi de 33,3 para cada 10.000 partos. A onfalocele foi diagnosticada em 43 casos e a gastrosquise em 31. Foram tambem encontrados doze casos de sindrome de Body-Stalk, cinco de extrofia de cloaca, seis de Pentalogia de Cantrell, dois de sindrome da banda amniotica e um de sindrome de Beckwith-Wiedemann. Foram excluidos 18 casos cujos partos ocorreram fora do servico. Entre os 82 restantes, o tabagismo foi relatado por 14,7% das mulheres com fetos com onfalocele e por 22,2% nos casos de gastrosquise. As medias de idade materna e paridade foram 27,5 e 2,5 nos casos de onfalocele e 19,5 e 1,4 nos de gastrosquise, respectivamente. A cesariana foi realizada em 67,7% dos casos de onfalocele e em 81,5% dos casos de gastrosquise, e a maioria dos partos ocorreu com mais de 34 semanas de gestacao (61,8% e 77,8%, respectivamente). A media de peso dos recem-nascidos com onfalocele foi 2151,2 e dos com gastrosquise foi 2243,3 gramas. O indice de Apgar de primeiro minuto foi maior ou igual a sete em 35,3% dos recem-nascidos com onfalocele e em 63% daqueles com gastrosquise. O de quinto minuto foi maior ou igual a sete em 58,8% e 96,3%, respectivamente. Os neonatos com gastrosquise foram submetidos a correcao cirurgica em 96,3% dos casos e receberam alta hospitalar vivos em sua maioria. Conclusao: A frequencia de malformacoes de parede abdominal encontrada no servico estudado foi mais alta do que aquela relatada na literatura. A media de idade materna foi baixa nos casos de gastrosquise. Os maiores indices de Apgar foram obtidos pelos fetos com gastrosquise. Estes foram submetidos a correcao cirurgica e receberam alta vivos em sua grande maioria Abstract
Investigation of Hybrid Molecular/Silicon Memories With Redox-Active Molecules Acting as Storage Media

In this paper, a physical investigation of hybrid molecular/Si memory capacitor structures is proposed, where redox-active molecules act as storage medium. Fc and ZnAB3P porphyrin were grafted on (100) Si with both a direct bond and a chemical linker in order to investigate the electron transfer properties of the molecule/Si system. The chemical structures of the molecular layers were analyzed with X-ray photoelectron spectroscopy. Cyclic voltammetry and impedance spectroscopy were also performed on capacitor structures in order to characterize the charge transfer between the redox molecules and the Si and the effect of an organic linker on its rate. To explain our results, an original electrical model of molecule/Si memory structures is proposed. Calculated data are compared to impedance results for the cases of Fc either directly grafted or with linker. The model allows us to give a theoretical confirmation of the influence of the linker over the redox energy and on the time constant of the molecular capacitor. Finally, density functional theory calculations provide an in-depth physical insight of the effect of the linker over the Fc redox energy. The results obtained in this paper show the strong impact of the engineering of the redox molecules and their linker on the electron transfer properties.
Selective detection of 2‐nitrobenzenesulfenyl‐labeled peptides by matrix‐assisted laser desorption/ionization‐time of flight mass spectrometry using a novel matrix

The 2‐nitrobenzenesulfenyl (NBS) method, which is useful for quantitative proteome analysis, is based on stable isotope labeling of tryptophan residues with NBS chloride (12C6‐NBSCl or 13C6‐NBSCl). We found that 3‐hydroxy‐4‐nitrobenzoic acid (3H4NBA) is a more suitable matrix than 2,5‐dihydroxybenzoic acid (DHB) for detecting NBS‐labeled peptides by MALDI‐quadrupole IT (QIT)‐TOF MS . Furthermore, NBS‐labeled peptides were selectively ionized and detected in a mixture of NBS‐labeled and unlabeled peptides. Labeled paired peaks were easily detected without enrichment, nonpaired labeled peaks were clearly distinguished from unlabeled contaminating peptides, and nitrotyrosine‐containing peptides were also selectively detected on the 3H4NBA matrix, while by‐product‐peaks arising from nitrobenzene moieties were suppressed. The use of 3H4NBA as a comatrix with CHCA improved the sensitivity of detection while substantially retaining the selectivity of 3H4NBA. The 3H4NBA matrix offers great advantages in terms of simplicity, sensitivity, and usability when used for the NBS method and for MALDI‐TOF MS analysis applied to compounds having a nitrobenzene ring.
PDE 4-inhibitors : A novel , targeted therapy for obstructive airways disease

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. PDE4-inhibitors: A novel, targeted therapy for obstructive airways disease Zuzana Diamant, Domenico Spina
How we treat: risk mitigation for ABO‐incompatible plasma in plateletpheresis products

P latelet (PLT) transfusions with ABOincompatible plasma rarely result in severe hemolytic reactions. Most transfusion services attempt to issue ABO plasma–incompatible PLTs for transfusion but are not always able to do so because of inventory limitations and other requirements such as cytomegalovirus-compatible, irradiated, and/or HLAcompatible PLTs. Thus it is common practice for PLT units that are plasma ABO incompatible to be selected for transfusion. ABO plasma incompatibility can become clinically relevant when O PLT units with high-titer anti-A or anti-B isoagglutinins are transfused into non-group O patients. Here, we present a case of severe hemolysis and death after transfusion of a group O apheresis PLT unit in a patient whose ABO typing result recently converted from group O to group A after an ABO-incompatible hematopoietic stem cell transplant (HCT). Before this event, our policy limited ABO-incompatible plasma to 350 mL per transfusion event for adults and used an age-based algorithm for pediatric patients. Nationwide, different strategies are now being developed to minimize hemolysis related to transfusion of PLTs containing ABOincompatible plasma. Some of these strategies include matching PLTs with the ABO type of the recipient or increasing the number of non-O type PLTs in the inventory; however, inventory reality often limits the ability of a transfusion service to only supply ABO plasma– compatible units. An alternative strategy is to dilute any potential high-titer isoagglutinin-containing unit by the use of random pooled PLTs and/or plasma reduction and replacement with a PLT additive at the time of collection. These approaches are currently utilized in Europe but not commonly in the United States. Titrations for anti-A and anti-B isoagglutinins on each PLT product may be the optimal measure to be considered to identify high-titer anti-A, anti-B PLT units that would be unacceptable for use in non-group O patients. However, there is not yet a consensus between acceptable and potentially harmful titers, and titration methods are not yet standardized. Thus plasma volume reduction remains an alternative to the above strategies. Given that the technology and expertise for volume reduction were already available and could be implemented immediately after this sentinel event for our transfusion service, we have revised our PLT inventory management policy as described in this report.
Theory of Mind in Bilingual and Monolingual Preschool Children

Abstract This research examined whether theory of mind (ToM) development differs in bilingual and monolingual preschool children. Three false belief tasks were given to 163 Kurdish-Persian bilingual and Persian monolingual preschool children. Bilingual children performed significantly better than monolingual children in their ToM. Hierarchical multiple regression analysis revealed that, bilingualism contributed significantly to the prediction of preschoolers’ ToM development when age and verbal ability were controlled.
Multilayered Image Processing for Multiscale Harris Corner Detection in Digital Realization

The PC-based software programming used in complex or luxuriant image processing algorithms is time consuming and resource wasting. As appropriate processing for the image data indeed speedups complicated algorithms, we focus on a crucial case - multilayered processes. In this paper, we gauge deeply into the data flow of multilayered image processing to avoid waiting for the result from every previous steps to access the memory which occurs in many applicable algorithms. Based on combining the parallel and pipelined properties to eliminate unnecessary delays, we propose new visual pipeline architecture and use field programmable gate array to implement our hardware scheme. For verification, the multiscale Harris corner detector in cooperating with shape context and thin-plate splines were combined to complete our real-time experiment of the integrated hardware and software (H/S) system for pattern recognition.
A Review : Biological Effects of Magnetic Fields on Rodents

This review is aimed to summarize the experimental researches in the influences of Static Magnetic Field (SMF), Pulsed Electromagnetic Field (PEMF), and Radio Frequency Electromagnetic Field (RF-EMF) on laboratory rodent models reported by laboratory scientist, experimental technicians, physicians, veterinarians and other researchers. Past studies suggested that, the application of SMF, PEMF and RF-EMF on rodents were influences the body functions such as hypertension, musculoskeletal disorders, nerve functions, glucose and lipid metabolism, bone disorders, tissue growth, fertility, reproduction, growth. But on the other hand some harmful events have also been observed in number of investigation. So exposure to different types of magnetic field have dual effect on experimental rodents, where positive effect on whole body system are clearly carried out in SMF studies compare to PEMF, RF-EMF. In this, SMF of moderate intensity strength provide beneficial effect on alteration in metabolism of rodents. Further researches need to perform with moderate intensity SMF should provide suitable alternate therapy for metabolic disorders in future clinical trial.
Are Dietary Patterns Associated with Depression in U.S. Adults?

Nutrition is one of the most important modifiable determinants for and consequences of both mental and physical heath. Depression has become an increasingly important public health issue. We tested whether dietary patterns derived from food group intake are associated with depression in U.S. adults in a cross-sectional study with national population. This study included 4180 men and 4196 women aged 20-79 years in the 2007-2010 National Health and Nutrition Examination Surveys (NHANES), with complete data of one 24-h dietary recall, sociodemographics, lifestyles, and Patient Health Questionnaires (PHQ-9) for screening depression. Two major dietary patterns identified by factor analysis were investigated for their associations with presence of depression (PHQ-9 score ≥10) by using linear and multivariate logistic regressions. One of two major patterns, labeled "Western" dietary pattern was characterized by high intakes of nonwhole grain, white potatoes, cheese, meat, discretionary oil and fat, and added sugar; the second dietary pattern that was labeled "Healthy" dietary pattern was characterized by high intakes of whole grains, vegetables, fruits, fish, nuts and seeds. The "Western" dietary pattern was not significantly associated with depression in both men and women. The "Healthy" dietary pattern scores were inversely associated with the PHQ-9 depression scores and odd ratios (ORs) of depression after adjustment for covariates in women but not in men. The OR of depression in women with the highest quintile of "Healthy" dietary pattern scores was 0.60 (95% confidence interval [CI]: 0.42-0.85, P < .001) compared to the lowest quintile as a reference. These findings warrant future interventions or clinical trials in elucidating causal and effect relations of depression and dietary patterns, an important public health concern.
Prediction of time series based on load profile using JADE technique

This paper presents a method of mathematical technique using Joint Approximate Diagonalization of Eigen Matrices (JADE). The advantages of this method, it can predict the original analysis of source signal using limited information of the system as well as to minimize costs by reducing the number of equipment to estimate the type of load profile at certain locations. By using innovative methods based Power System Simulation (PSS™E) software, Phyton Programming, Matlab software and Microsoft Excel are implemented. The proposed technique is tested on 69 test bus system and several results such as simulation and error measures are also discussed in this paper.
Mesurer et contrôler. Les temps de l'organisation du travail dans les manufactures de laine de Padoue (xvie-xviie siècles)

L’article etudie les formes et les methodes utilisees dans la mesure du temps de travail a l’epoque moderne, en prenant comme objet d’etude les manufactures lainieres de Padoue entre les xvie et xviie siecles. Il montre comment la relation etablie entre temps et travail avait contribue a la regulation et au calcul de la productivite reelle du travailleur, ainsi qu’a la creation de systemes d’incitation et de formes de controle direct sur le travail, relevant en grande partie de la corporation de la laine et de son tribunal.
The effect of ethinylestradiol-containing contraceptives on the serum concentration of olanzapine and N-desmethyl olanzapine.

AIM To investigate the potential interaction between olanzapine, a CYP1A2 substrate, and ethinylestradiol-containing contraceptives (ECC). METHODS The study was carried out at a routine therapeutic drug monitoring service. To identify patients who were co-administered ECC or other contraceptives, a questionnaire was sent to the physician who ordered serum monitoring of olanzapine for women aged 18-40 years during an 18 month period. The physicians were asked to provide information about contraceptive use and smoking habits. When questionnaires were returned by the physicians, the respective serum concentration data were included in the analysis. Patients were stratified into users of ECC, progestogen-based contraceptives (PBC) or no contraceptives. Dose-adjusted serum concentrations of olanzapine and the metabolite N-desmethyl olanzapine were compared between the subgroups. RESULTS A total of 149 patients were included in the study (10 ECC users and 10 PBC users). In users of ECC, we found no differences in serum concentrations of olanzapine, but significantly lower concentrations of the CYP1A2-mediated metabolite N-desmethyl olanzapine compared with users of PBC (P = 0.019) and non-contraceptive users (P = 0.012). CONCLUSION The present study confirms that ECC exhibit CYP1A2-inhibitory properties in terms of significantly lower exposure of N-desmethyl olanzapine. However, the inhibition does not provide clinically relevant changes in serum concentrations of olanzapine.
A Note on the Names of Selected Magicians

Abstract This note defines the concept of “magic” and comments on the meaning of its various synonyms. Second, it suggests a typology of names based on 150 selected stage names or pseudonyms employed by magicians. Finally, it contains an appendix with a selected list of magicians’ stage names and real names including birth and death dates (where available) and place of birth (where available).
A THREE-YEAR STUDY OF THE FEEDING HABITS OF CULEX TARSALIS IN KERN COUNTY, CALIFORNIA.

Summary Over a three-year period, 10,229 blood-engorged Culex tarsalis were collected in rural areas of Kern County, California. These blood meals were identified with precipitating antisera prepared in birds and rabbits. C. tarsalis had a variable feeding pattern, showing a preference for passerine birds at all seasons but most pronounced in the winter. There was a significant increase in feedings on doves and mammals at the height of the summer. The feeding patterns reflected the abundance of different animal species in proximity to the collecting sites. Collections of C. tarsalis from habitats believed to favor feeding on man or rodents failed to yield any feedings on these hosts. Only six feedings on rodents and three on reptiles were detected. The feeding habits of C. tarsalis in Kern County would indicate that passerine birds and doves are the most likely hosts of Western equine and St. Louis encephalitis viruses.
Multimedia messaging service for GPRS and UMTS

Mobile telecommunications networks will evolve to a great extent in the future. They will offer higher data rates and provide new services for nomadic users. The development of packet switched data bearers for 3/sup rd/ generation wireless networks will enable support for multimedia applications as well. Multimedia can be divided into real-time and non-real-time services. In this paper we concentrate on a new non-real-time multimedia service called multimedia messaging service (MMS). Multimedia messaging service allows mobile subscribers to exchange arbitrary types of information in a store-and-forward manner. Multimedia messages may consist of text, images, audio or video clips, or any combination of these. A new network element called multimedia messaging service center is needed for storing and forwarding the messages. We describe in more detail what we mean by multimedia messaging service. We also analyze the different architectural options for supporting multimedia messaging within UMTS (Universal Mobile Telecommunications System) and GPRS (General Packet Radio Service for GSM) networks.
Chromosome 18 deletions are common events in classical midgut carcinoid tumors

Classical midgut carcinoids are rare intestinal neuroendocrine tumors that often present with metastases at diagnosis. In contrast to foregut carcinoids, midgut carcinoids are not related to the multiple endocrine neoplasia type 1 syndrome, and the mechanisms involved in their tumorigenesis are unknown. Eight classical midgut carcinoids were analyzed by genome‐wide screening for loss of heterozygosity. Deletions on chromosome 18 were found in 88% of the tumors. DNA sequencing and immunohistochemical staining for Smad4/DPC4, which often is homozygously mutated in pancreatic and colon carcinomas, revealed no aberrations. In 1 tumor, a region telomeric to the Smad4/DPC4/DCC genes at 18q21 was deleted. Other chromosomes were affected in 3 lesions only. The high frequency of chromosome 18 deletions strongly indicates a genetic alteration of importance in classical midgut carcinoid tumorigenesis, apparently not involving the Smad4/DPC4 gene. © 2001 Wiley‐Liss, Inc.