Miracle-dz/UniFAR-FTUs huggingface dataset:
Conflicting Effects of Coffee Consumption on Cardiovascular Diseases: Does Coffee Consumption Aggravate Pre-existing Risk Factors?

Coffee is one of the most popular beverages worldwide. Its effect on health is generally regarded as beneficial in many studies. However, there are growing concerns about the adverse effect of coffee consumption on cardiovascular disease (CVD) due to the potential aggravating impact on the cardiovascular system attributed to various compounds within coffee. This review is focused on deteriorative effects of coffee consumption on CVDs with possible mechanisms. Patients with risk factors of CVDs should prudently consider heavy consumption of coffee as it may exacerbate hypertension, dyslipidemia, and atherosclerosis, and increase the odds of cardiovascular events. J-shaped or U-shaped dose-response graphs of coffee consumption and CVD parameters partially explain the inconsistency of conclusions between coffee studies on CVD, highlighting a moderate intake of coffee. Moreover, there are discrepancies in results from clinical studies elucidating considerable influences of confounding factors including gender and smoking status on outcomes of those conducted to reveal the actual impact of coffee consumption on CVDs. Physical features of subjects including genetic variations and body mass index (BMI) make it difficult to determine moderate intake of coffee for individuals in terms of caffeine metabolism. Further epidemiological studies with consideration about characteristics of the study population are needed to determine the exact effect of coffee consumption on CVD.
Towards an Ethico-Aesthetic of Parenting: Sensing Ritornellos of Play with GoPro Data

This article argues for an ethico-aesthetic approach to parenting as an alternative to the neoliberalisation of parenting, and its critiques. This ethico-aesthetic approach focuses on affect and the intensification of collective life. In the article, it is explored in connection to a group of parents and children under six who participated in a play event called Moving with lines and light. As parents, researchers and players who participated in this play event, the authors think together with fragments of GoPro data and the concept of the ritornello. They do this as an exercise in sensing the non-linear time of parenting in/with the play through a prolonged, active and relational process of recollection and narration that combines analogic and technologic events. With these, the authors discuss the parenting body in postdevelopmental modes of existence organized around sense, territory and technicity that propel a thinking of parenting beyond practices of symbolic control, and as living ecologies of action.
Bibliotheks- und InformationswissenschaftlerInnen in der Twittersphäre:

Der vorliegende Artikel stellt eine Kurzversion der Bachelorarbeit „Microblogging in den Informationswissenschaften – Quantitative Untersuchungen exemplarischer Communities auf Twitter“ dar und enthalt geringfugige Anderungen sowie nachtraglich vorgenommene Hinweise. Die genannte Bachelorarbeit versteht sich als eine erste Bestandsaufnahme uber die Zusammensetzung der bibliotheks- und informations-wissenschaftlichen Community auf Twitter und insbesondere in Bezug auf ein mogliches methodisches Vorgehen bei der Analyse des zugehorigen sozialen Netzwerks. Hierzu wurde unter anderem die Reprasentation der Informationswissenschaften auf der Microblogging-Plattform im Hinblick auf AkteurInnen sowie einzelne informationswissenschaftliche Themenfelder untersucht.
The complete chloroplast genome sequence of Populus wulianensis

Abstract The whole chloroplast genome sequence of Populus wulianensis was assembled and characterized. Its length was 156,553 bp, containing a large fragment of 84,726 bp and a small fragment of 16,551 bp separated by a pair of inverted repeat regions of 27,638 bp. A total of 129 genes were determined in the chloroplast genome, including 84 protein-coding genes, 37 tRNA genes, and 8 rRNA genes. The maximum-likelihood phylogenetic analysis showed that P. wulianensis was close to P. adenopoda but far from P. davidiana. The report here clearly displayed its origin and taxonomic status in Populus.
Phytoremediation of toxic metals : using plants to clean up the environment

Why Use Phytoremediation? (B. Ensley). ENVIRONMENTAL POLLUTION AND GREEN PLANTS. Phytoremediation's Economic Potential (D. Glass). Phytoremediation and Public Acceptance (R. Tucker & J. Shaw). Regulatory Considerations for Phytoremediation (S. Rock & P. Sayre). TECHNOLOGIES FOR METAL PHYTOREMEDIATION. Phytoextraction of Metals (M. Baylock & J. Huang). Phytostabilization of Metals (S. Cunningham & W. Berti). Phytofiltration of Metals (Y. Kapulnik & S. Dushenkov). The Use of Plants for the Treatment of Radionuclide (M. Negri & R. Hinchman). Photostabilization of Metals Using Hybrid Poplar Trees (J. Schnoor). Phytoreduction of Environmental Mercury Pollution (C. Rugh, et al.). The Physiology and Biochemistry of Selenium Volatilization By Plants (M. de Souza, et al.). BIOLOGY OF METAL PHYTOREMEDIATION. Metal Accumulating Plants (R. Reeves & A. Baker). Mechanisms of Metal Hyperaccumulation in Plants (D. Salt & U. Kramer). Mechanisms of Metal Resistance: Phytochelatins and Metalothioneins (C. Cobbett & P. Goldsborough). Molecular Mechanisms of Ion Transport in Plant Cells (M. Guerinot).
Response of Soil Denitrifying Communities to Long-Term Prescribed Burning in Two Australian Sclerophyll Forests

Low-intensity prescribed burning is a common forest management tool and plays a major role in modifying biogeochemical cycling through the alteration of substrate availability and microbial communities. In this study, we assessed the response of microbial community to repeated prescribed burning in two sclerophyll forests (the Bauple site, dry, annual rainfall 1000 mm; and the Peachester site, wet, 1711 mm) in southeast Queensland, Australia. At the dry sclerophyll forest (the Bauple site), annual and triennial burning did not significantly alter the soil carbon (C) and nitrogen (N) content, while at the wet scleophyll forest (the Peachester site), two yearly burnings resulted in significantly lower soil total C and N contents compared to the long unburnt treatment. In spite of these different responses, prescribed burning regimes did not significantly influence the abundance of 16S rRNA or denitrifying gene (narG, nirK, nirS, nosZ) at both sites. These results indicated that, long-term prescribed burning has little effect on the denitrifying communities, while it has varying effects on soil chemical properties at the two sites, which are likely to be explained by differences in vegetation type and soil moisture regime.
Effect of MyoMAX on carcass lean and fat

Previous research has identified quantitative trait loci (QTL) for increased lean meat yield and decreased fat in similar regions of sheep chromosome 2, in New Zealand and Belgian Texels (Broad et al., 2000; Johnson et al., 2005; Laville et al., 2004; Marcq et al., 2002). In the case of the Belgian Texels it has been demonstrated that a single G to A transition (g+6723G-A) in the 3’ untranslated region of the growth and differentiation factor 8 (GDF8) gene is responsible for the QTL effect (Clop et al., 2006). Recently, the presence of the A allele was confirmed in Australian Texels (Kijas et al., 2007). However, the presence and effect of the A allele in New Zealand Texels has not been confirmed. In addition, previous studies have only reported the size of the QTL effect in animals inheriting a single copy of the A allele. The purpose of this study was to determine the effects of zero, one, or two copies of the A allele in New Zealand Texel cross animals at varying lamb ages and carcass weights, using both computer tomography (CT) and Viascan (a two dimensional imaging system that estimates lean content of the carcass (Hopkins et al., 2004)) to estimate lean and fat content in primal cuts.
Pamuk Üretiminin Ekonomik Analizi: Manisa Örneği

Bu calismada, Manisa Ili, pamuk uretim ekonomisi, pamuk uretiminde girdi miktari, maliyet duzeyi, kârlilik oranlari ve verimlilik analizleri ele alinmistir. Arastirma, Manisa Ilinde faaliyette bulunan pamuk ureten isletmelerdeki, pamuk uretim ekonomisini ve analizini ortaya koymak amaciyla yapilmistir. Arastirmada kullanilan birincil veriler, Manisa ilinde pamuk uretimi yapan ureticilerden anket yontemi kullanilarak elde edilmistir. Pamuk uretimi yapan isletmelerden elde edilen veriler 2018 uretim donemine aittir. Calismada; dekara pamuk veriminin 430 kg ila 690 kg arasinda degismekte oldugu, ortalama verimin ise 569,1 kg/da oldugu gorulmektedir. Isletmelerin uretim maliyetleri icinde en buyuk pay %36,64 ile iscilik giderlerine ve %19,29 ile girdi maliyetlerine aittir. Degisken masraflarin toplam maliyet icindeki payi %60,36 oranindadir. Gayri safi uretim degerinin 2.690 tl/da ve bir kilogram pamuk uretim maliyetinin de 2,17 tl/kg oldugu gorulmustur. Pamuk uretim faaliyetinin karliliginin artirilmasi icin; girdi maliyetlerinin dusurulmesi ve destekleme ucretlerinin bir onceki cari doneme gore yeniden degerleme oraninda yukseltilmesi, tesvik priminin her yil en az enflasyon oraninda artirilmasi ve zamaninda odenmesi, lisansli depoculugun yaygin ve etkili olarak kullanilmasi, girdilerin etkinliginin ve verimin artirilmasi ile islah calismalarina yeterli destek ve tesvikin verilmesi gerekmektedir.
Research on the Design and Application of Implicit Semantic Model in Bundle Recommendation Method

The recommendation system has been studied for a long time. Data of more users and commodities has been used to improve precision of the recommendation system. However, few studies are on utilization of bundling information. The bundling information refers to the inherent connection of the commodities, and depended by objective properties of commodities. This paper adds bundling information to the recommendation method based on traditional implicit semantic model and collaborative filtering method. This paper sets the bundling coefficient to show the connection degree between commodities and recommended decisive factors. Experiment shows the precision of recommendation could be improved with bundling information in specific environment through changing bundling coefficient.
Mechanisms and Causes of Osteoporotic Hip Fractures in Elderly Patients

Amaç: Türk toplumunda yaşlı hastalarda osteoporotik kalça kırık nedenlerini ve oluş mekanizmasını araştırmak. Gereç ve Yöntem: 2013-2014 yıllarında kalça kırığı nedeniyle kliniğimizde ameliyat edilen 83 ardışık hasta çalışmaya dahil edildi. Hastaların demografik özellikleri, kırık oluş nedenleri ve kırık tipleri, oluş mekanizması, kırığın olduğu yer, hastaların yalnız yaşayıp yaşamadığı ve yürümek için destek kullanıp kullanmadığı kaydedildi. Bu bilgiler retrospektif olarak değerlendirildi ve cinsiyete göre karşılaştırılarak analiz edildi. Bulgular: Hastaların %94’ü sağ veya sola doğru kalça eklemi üzerine ve %74’ü herhangi bir çevresel faktöre bağlı olmaksızın dengelerini kaybederek düşmüştür. Düşmelerin %80’i ev içinde olmaktadır ve hastaların %56’sı yürümeye yardımcı destek kullanmaktadır. Hastaların sadece %18’i evde yalnız yaşamaktadır. Vücut Kitle indeksi değerlerine göre hastaların sadece %3’ü obez veya aşırı kilolu iken %49’u düşük kiloludur. Sonuç: Yetmiş beş yaş üstü kalça kırığı olan hastaların çoğu düşük kilolu ve bakım için yardım alan kişilerdir. Kırıkların çoğu herhangi bir çevresel faktöre bağlı olmaksızın denge kaybı nedeniyle oluşmaktadır ve hastaların çoğu öne ya da arkaya değil yan tarafa doğru düşmektedir. Hasta kıyafetlerinin ve zeminin düşme esnasında oluşan travma şiddetini azaltacak şekilde modifiye edilmesi kalça kırığı insidansını azaltmaya yardımcı olabilir. Anahtar kelimeler: Kalça, kırık, neden, mekanizma, yaşlı hastalar, osteoporoz Mechanisms and Causes of Osteoporotic Hip Fractures in Elderly Patients
Regulation Of Fatty Acid Desaturase Expression And Alternative Splicing

The FADS1 and FADS2 genes encode fatty acid desaturases required for synthesis of omega-3 and omega-6 long-chain polyunsaturated fatty acids (LCPUFA) important in the central nervous system, inflammatory response, and cardiovascular health. Single nucleotide polymorphisms (SNPs) in these genes are associated with numerous health outcomes, but it is unclear how genetic variation affects desaturase enzyme function. Here, lymphoblasts obtained from Japanese in Tokyo participants in the International HapMap Project were evaluated for association of expression microarray results with SNPs in the FADS gene cluster. Six SNPs in the first intron of the FADS2 gene were significantly associated with FADS1 expression after Bonferroni correction. A 10-SNP haplotype in FADS2 (rs2727270 to rs2851682, permuted p = 0.028) present in 24% of the population was significantly associated with lower expression of FADS1, confirmed by qRT-PCR. A highly conserved region coinciding with the most significant SNPs contained predicted binding sites for PPARγ and SREBP. Lymphoblasts homozygous for either the major or minor haplotype were treated with agonists for these transcription factors, and expression of FADS1 and FADS2 measured. There was no difference by genotype in response to the PPARγ agonist rosiglitazone. The statin drug simvastatin and the LXR agonist GW3965 both upregulated expression of FADS1 and FADS2 through activation of SREBP-1c. Surprisingly, minor haplotype homozygotes had 2040% higher induction of FADS1 and FADS2 after simvastatin or GW3965 treatment, 24 suggesting enhanced responsiveness to SREBP-1c. Sequencing of the region flanking the putative sterol response element (SRE) in FADS2 identified two deletion mutations within 150 bp of the putative SRE in all minor haplotype carriers, and none among the major haplotype carriers studied. Individuals carrying the minor haplotype may be particularly vulnerable to alterations in diet that reduce LCPUFA intake, such as low fish consumption, and may be especially responsive to statin or marine oil therapy.
Caractérisation et expression de nouveaux éléments génétiques transposables de la superfamille Tcl-Mariner chez la microalgue marine Amphora acutiuscula (Bacillariophyta).

Les elements genetiques transposables (ET) sont des sequences d’ADN capables de se deplacer dans tous lesgenomes sous certaines conditions. Les ET ont des structures et des modes de transposition qui lesdifferencient en plusieurs groupes. Les elements de la famille mariner sont ubiquistes ; lorsqu’ils sont actifs, ilsproduisent une transposase qui coupe l’element et l’insere dans un autre locus. Des fragments d’elements detype mariner (MLE) ont ete precedemment identifies chez la diatomee marine Amphora acutiuscula et ils semblaientactifs en condition de stress thermiques. Les diatomees sont caracterisees par une paroi siliceuse ornementee et,dans le milieu marin, elles jouent un role primordial dans les chaines alimentaires.Dans le present travail, par des methodes de biologie moleculaire et de bioinformatique, nous avons recherche et caracterise des MLE complets, et precise leur activite en conditions de chocs thermiques et metalliques (cuivre et zinc). L’analyse des sequences amplifiees a mis en evidence la presence de MLE particuliers chez cette diatomee qui code une transposase ayant une triade catalytique DD43D jamais decrite jusqu’a present.L’analyse phylogenetique place les MLE de diatomees dans une sousfamille differente mais proche de celle desMLE de plantes. Parmi les nombreuses copies de MLEpresentes dans le genome d’A. acutiuscula, certaines sont exprimees lorsque la diatomee est placee pendant 2 a 5 heures a unetemperature inferieure a sa temperature de culture. Par contre, l’expression des MLE n’a pas ete mise en evidence chez cette espece soumise aux stress metalliques appliques.
Using Mendelian randomization to understand and develop treatments for neurodegenerative disease

Abstract Common neurodegenerative diseases are thought to arise from a combination of environmental and genetic exposures. Mendelian randomization is a powerful way to leverage existing genetic data to investigate causal relationships between risk factors and disease. In recent years, Mendelian randomization has gathered considerable traction in neurodegenerative disease research, providing valuable insights into the aetiology of these conditions. This review aims to evaluate the impact of Mendelian randomization studies on translational medicine for neurodegenerative diseases, highlighting the advances made and challenges faced. We will first describe the fundamental principles and limitations of Mendelian randomization and then discuss the lessons from Mendelian randomization studies of environmental risk factors for neurodegeneration. We will illustrate how Mendelian randomization projects have used novel resources to study molecular pathways of neurodegenerative disease and discuss the emerging role of Mendelian randomization in drug development. Finally, we will conclude with our view of the future of Mendelian randomization in these conditions, underscoring unanswered questions in this field.
Model-simulated Source Contributions to PM2.5 in Santiago and the Central Region of Chile

The contributions to PM2.5 from different emission sectors across central Chile and the Santiago metropolitan area during summer/fall and winter have been evaluated using a chemical transport model. The simulations generally underestimate the mean PM2.5 concentrations compared to measurements conducted at stations in Santiago that belong to the Chilean National Air Quality Information System (SINCA). The potential reasons for this discrepancy include underestimated direct PM2.5 emissions, missing emissions for semi-and intermediately volatile organic compounds (SVOCs and IVOCs) and overestimated wind speeds in the simulations. The simulated winter PM2.5 concentrations in Santiago are lower and higher than the values observed during nighttime, and daytime and late evening, respectively, which may be related to excessive simulated wind speeds, as well as to uncertainties in the diurnal variation in the emissions. During summer/fall, the simulated diurnal variation better agrees with the observations, but the peak concentrations during the morning are underestimated, whereas those during the evening are overestimated. The simulated contributions of different aerosol components to the PM2.5 at one station in Santiago are all lower than the observed values, except for elemental carbon equivalent black carbon (BCe), which exhibit comparable or higher levels in the simulations. The absolute differences are the largest for the total organic matter, whereas the relative differences are the largest for BCe and ammonium. The simulated sector contributions indicate that emissions originating from transport and construction machinery dominate the PM2.5 in Santiago; however, residential wood combustion is the primary source in other urban areas of central Chile, except near major point sources. Away from urban areas, traffic routes and major industrial sources, secondary inorganic aerosol (SIA) is estimated to be the largest component of the aerosol, whereas the simulated secondary organic aerosol (SOA) only contributes a small fraction.
Towards data-driven approaches in manufacturing: an architecture to collect sequences of operations

The technological advancements of recent years have increased the complexity of manufacturing systems, and the ongoing transformation to Industry 4.0 will further aggravate the situation. This is leading to a point where existing systems on the factory floor get outdated, increasing the gap between existing technologies and state-of-the-art systems, making them incompatible. This paper presents an event-based data pipeline architecture, that can be applied to legacy systems as well as new state-of-the-art systems, to collect data from the factory floor. In the presented architecture, actions executed by the resources are converted to event streams, which are then transformed into an abstraction called operations. These operations correspond to the tasks performed in the manufacturing station. A sequence of these operations recount the task performed by the station. We demonstrate the usability of the collected data by using conformance analysis to detect when the manufacturing system has deviated from its defined model. The described architecture is developed in Sequence Planner – a tool for modelling and analysing production systems – and is currently implemented at an automotive company as a pilot project.
Chipless RFID Readers for Frequency-Coded Tags: Time-Domain or Frequency-Domain?

Printable ultra-wideband (UWB) frequency-coded chipless radio frequency identification (RFID) tags are suitable candidates for barcode replacement toward developing smart objects. A high-performance and low-cost UWB chipless RFID reader is needed to interrogate UWB frequency-coded tags. Time-domain and frequency-domain techniques are the most popular approaches employed in readers to extract the tag information. This paper reviews the state-of-the-art frequency- and time-domain chipless RFID readers for reading frequency-coded tags. A comprehensive study on the main challenges in designing a sound reader such as detection range, immunity to the interferences, detection speed and accuracy, cost, reader profile, and compatibility with hybrid tags is conducted. Finally, a new reader architecture for reading hybrid tags to achieve higher data capacity is presented. The reader is capable of detecting a chiplesstag independent of its orientation and has considerable potential for commercial realization.
Évaluation exergetique des changements metaboliques sur l’esperance de vie des fumeurs

Quelques auteurs ont determine le comportement exergetique du corps humain dans des conditions standard. Certaines de ces etudes comprennent une estimation de l'esperance de vie basee sur l'association de la creation d' entropie / destruction exergetique et la theorie du taux de vie. Le metabolisme est connu comme source d'irreversibilite majeure dans le corps humain. Ainsi, les alterations metaboliques devraient affecter son comportement exergetique et, selon le theorie de taux de la vie, l'esperance de vie. Certains auteurs ont decouvert que meme les fumeurs sans maladies liees au tabagisme presentent un metabolisme plus eleve que les non-fumeurs, qui contribue a la prise de poids apres l'arret du tabac. Selon la litterature medicale, le metabolisme des fumeurs est 20% superieur a celui des non-fumeurs, en plus de l'effet thermogenique apres avoir fume des cigarettes. Dans le present travail, l'analyse exergetique est appliquee au corps humain afin d'evaluer l'effet de l'augmentation metabolique chez les fumeurs sur le comportement exergetique et l'esperance de vie. L'analyse prend en compte les taux d'exergie dus a la convection, au rayonnement, a la respiration, a l'evaporation et au metabolisme exergetique. Un modele thermique a segments multiples du corps humain disponible dans la litterature est utilise pour effectuer une analyse energetique. Les resultats de l' exergie detruite integree sur la duree de vie indiquent qu'un fumeur detruit environ 730 MJ/kg d'exergie en plus qu'un non-fumeur jusqu'a l'âge de 73,5 ans, ce qui representerait une diminution de 15 ans de l'esperance de vie pour ce groupe.