Miracle-dz/UniFAR-FTUs huggingface dataset:
Hemodynamic effects of fluid loading in acute massive pulmonary embolism.

OBJECTIVE To assess the hemodynamic effects of fluid loading in patients with acute circulatory failure caused by acute massive pulmonary embolism (AMPE). DESIGN Prospective study. SETTING Respiratory critical care unit of a university hospital. PATIENTS Thirteen patients free of previous cardiopulmonary disease with angiographically proven AMPE (Miller index = 24 +/- 1), with acute circulatory failure defined by a cardiac index (CI) lower than 2.5 L/min/m2. INTERVENTION Infusion of 500 mL of dextran 40 over 20 mins. MEASUREMENTS AND MAIN RESULTS Fluid loading induced a substantial increase in right atrial pressure from 9 +/- 1 mm Hg to 17 +/- 1 mm Hg and in right ventricular end-diastolic volume index from 123 +/- 14 mL/m2 to 150 +/- 11 mL/m2 (p < .05 for both comparisons). The increase in right ventricular preload was associated with an increase in Cl from 1.6 +/- 0.1 to 2.0 +/- 0.1 L/min/m2 (p < .05), whereas right ventricular ejection fraction (15 +/- 3% at baseline vs. 16 +/- 3% after fluid loading) and total pulmonary vascular resistance index (1689 +/- 187 dyne x sec/cm5 x m2 at baseline vs. 1492 +/- 166 dyne x sec/ cm5 x m2 after fluid loading) remained unchanged. The increase in Cl induced by fluid loading was inversely correlated to baseline right ventricular end-diastolic volume index (r = -.89 ; p< .05). CONCLUSIONS These results suggest that fluid loading can improve hemodynamic status in patients with acute circulatory failure caused by AMPE.
SPECIFIC METABOLIC REPRESSION OF THREE INDUCED ENZYMES IN ESCHERICHIA COLI.

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Mapping of Microbiological Procedures by the Members of the International Society of Orthopaedic Centers (ISOC) for Diagnosis of Periprosthetic Infections

Despite multiple efforts at drafting a general guideline or consensus document, the major international orthopedic centers and the orthopedic community in general are still searching for a definitive, comprehensive and robust approach for the diagnosis and management of prosthetic joint infections (PJIs), although in the recent past many efforts have been made to establish uniform criteria and a worldwide accepted definition (1-3). ….
Fault prediction based on dissolved gas concentration from insulating oil in power transformer using Neural Network

Reliable and continued performance of power Transformer is the key to profitable generation and transmission of electric power. Failure of a large power transformer not only results in the loss of very expensive equipment, but it can cause significant guarantied damage as well. Replacement of that transformer can take up to a year if the failure is not disastrous and can result in tremendous revenue losses and fines. A Power Transformer in operation is subjected to various stresses like thermal stress and electrical stress, resulting in liberation of gases from the hydrocarbon mineral oil which is used as insulant and coolant. Dissolved Gas Analysis is a technique used to assess incipient faults of the transformer by analyzing specific dissolved gas concentrations arising from the deterioration of the transformer. DGA is used not only as a diagnostic tool but also to track apparatus failure. In this research work the dissolved gas values measured in PPM for a 230KV/110KV Power Transformer which are obtained from Electricity Board are used as references to the developed Neural Network. The Neural Network was trained and the gas concentration values for forthcoming years were predicted. Using the interpretation result of Key gas method, Rogers method and IS: 10593 method, the predicted gas concentration values compared and the fault of the Power Transformer were predicted. The trained Neural Network shows the good performance for the prediction of fault in a 230KV / 110KV Power Transformer.
Social influences on mammalian circadian rhythms: animal and human studies

While light is considered the dominant stimulus for entraining (synchronizing) mammalian circadian rhythms to local environmental time, social stimuli are also widely cited as‘zeitgebers’(time‐cues). This review critically assesses the evidence for social influences on mammalian circadian rhythms, and possible mechanisms of action. Social stimuli may affect circadian behavioural programmes by regulating the phase and period of circadian clocks (i.e. a zeitgeber action, either direct or by conditioning to photic zeitgebers), by influencing daily patterns of light exposure or modulating light input to the clock, or by associative learning processes that utilize circadian time as a discriminative or conditioned stimulus. There is good evidence that social stimuli can act as zeitgebers. In several species maternal signals are the primary zeitgeber in utero and prior to weaning. Adults of some species can also be phase shifted or entrained by single or periodic social interactions, but these effects are often weak, and appear to be mediated by social stimulation of arousal. There is no strong evidence yet for sensory‐specific nonphotic inputs to the clock. The circadian phase‐dependence of clock resetting to social stimuli or arousal (the‘nonphotic’phase response curve, PRC), where known, is distinct from that to light and similar in diurnal and nocturnal animals. There is some evidence that induction of arousal can modulate light input to the clock, but no studies yet of whether social stimuli can shift the clock by conditioning to photic cues, or be incorporated into the circadian programme by associative learning. In humans, social zeitgebers appear weak by comparison with light. In temporal isolation or under weak light‐dark cycles, humans may ignore social cues and free‐run independently, although cases of mutual synchrony among two or more group‐housed individuals have been reported. Social cues may affect circadian timing by controlling sleep‐wake states, but the phase of entrainment observed to fixed sleep‐wake schedules in dim light is consistent with photic mediation (scheduled variations in behavioural state necessarily create daily light‐dark cycles unless subjects are housed in constant dark or have no eyes). By contrast, discrete exercise sessions can induce phase shifts consistent with the nonphotic PRC observed in animal studies. The best evidence for social entrainment in humans is from a few totally blind subjects who synchronize to the 24 h day, or to near‐24 h sleep‐wake schedules under laboratory conditions. However, the critical entraining stimuli have not yet been identified, and there are no reported cases yet of social entrainment in bilaterally enucleated blind subjects. The role of social zeitgebers in mammalian behavioural ecology, their mechanisms of action, and their utility for manipulating circadian rhythms in humans, remains to be more fully elaborated.
The Iron Biogeochemical Cycle Past and Present

Presented here is a combined historical account, current synthesis and a perspective of how the modern Fe cycle functions, and how this cycle has evolved through geologic time. We begin by highlighting how new developments in nanogeoscience demonstrate the importance of nanoparticulate Fe (oxyhydr) oxide aggregates in the modern iron cycle. We further document how these aggregates are supplied from shelf sediments, aeolian dust and icebergs to the global ocean. Based on these observations, we present a kinetic model evaluating the supply of bioavailable Fe to surface seawater by ferrihydrite dissolution, photoreduction and siderophore-aided dissolution. The model indicates that the rate of delivery of bioavailable Fe from icebergs to the Southern Ocean is at least as large as that by wind-blown dust. However estimates of all the main aqueous, nanoparticulate and colloidal (and potentially bioavailable) Fe inputs to the ocean are poorly-constrained. We provide a historical perspective on the evolution of ideas as to how sedimentary pyrite formation is controlled and how these ideas led to the development of the Fe-based palaeoenvironmental proxies widely used today. This provides a springboard into our discussion of the ancient Fe cycle, which begins with a survey of how Fe interacts with a variety of other elements of biogeochemical interest including sulphur, oxygen and nitrogen. We highlight how interactions between these elements have evolved through geologic time, and how these interactions define the evolution of ocean and atmospheric chemistry. It is clear that the Fe cycle has gained a prominent role in regulating the biogeochemical function of the oceans through time. We offer, in the end, suggestions and a geochemical perspective as to how recent momentum in our understanding of the Fe cycle may be harnessed into catalysing future progress in the field.
Ontario Child Health Study: correlates of disorder.

Data from the Ontario Child Health Study were used to examine the prevalence and selected correlates of conduct disorder, hyperactivity, emotional disorder, and somatization in children 4 to 16 years of age by informant (parent and teacher for children 4 to 11, and parent and youth for children 12 to 16). The results indicate that the prevalence and pattern of correlates of the individual disorders differ in important ways by informant. This suggests that we need to understand the factors that influence assessments provided by informants from different contexts (e.g., parents and teachers) before combining information from them to arrive at singular classifications.
The binding of epidermal growth factor to the human uterus and leiomyomata in women rendered hypooestrogenic by continuous administration of an LHRH agonist

Summary. The binding of epidermal growth factor (EGF) to human myometrium and leiomyomata was assessed in a group of women rendered hypo‐oestrogenic with the LHRH agonist Zoladex (ICI118630). The results were compared with those obtained with tissues from women with normal cycles. Tn normal women, the specific binding of radiolabelled [125I] EGF to both myometrial and fibroid homogenates did not vary during the menstrual cycle, but the specific binding of [125I] EGF to fibroid in women treated with LHRH agonist was significantly less than in the untreated group. Since the hypo‐oestrogenic state induced by the agonist is associated with a decrease in fibroid size, the results suggest that the effect of oestrogen on fibroid tissue may partly be mediated by EGF.
[Relation between work-related stress and metabolic syndrome among Italian nurses.]

AIM To investigate the prevalence of metabolic syndrome (MS) among nurses, as well as the organizational impact of work-related stress as a consequence of MS among nurses in Italy. To study the organizational models, turnover rates, and job satisfaction among nurses, in a sample of Italian healthcare facilities. BACKGROUND MS is considered an important metabolic disorder in the modern world, responsible for diseases with economic effects on hospitals. Shift work (SW) seems to be a risk factor for MS, while the Mediterranean diet appears to be protective. Work-related stress causes loss of working days, and generates high costs for hospitals. DESIGN Prospective observational study. METHODS The first step will be to create and validate a questionnaire to investigate the prevalence of MS among Italian nurses. The second step will be to estimate the risk of work-related stress. Data regarding absenteeism and turnover will be collected, as indicators of impact on organization. DISCUSSION This study is the first to investigate the previously describe SW's factors and their impact on organizing nursing work. This study is relevant for the organizations because it helps to define organizational strategies that permit nurses to remain healthy, to be work efficient and therefore to be able to provide high level care.
Identification of Chemosensory Sensilla Mediating Antennular Flicking Behavior in Panulirus argus, the Caribbean Spiny Lobster

Crustaceans sample odorants by a rapid series of flicks of the two flagella composing the distal segments of each of the paired antennules. The lateral flagella contain aesthetasc sensilla that house unimodal chemosensory neurons. Nine types of nonaesthetasc setae with putative chemosensory and mechanosensory functions are distributed on the lateral and medial flagella. Sensory neurons in aesthetascs and nonaesthetasc sensilla terminate in separate regions of the brain, the olfactory lobe, and the lateral antennular neuropil, resulting in two odorant-processing pathways. Distilled water ablation of flagella and excision of specific setae were used to identify chemosensory sensilla mediating antennular flick behavior in Panulirus argus. The flick rates of sham-ablated and ablated or excised lobsters toward squid extract were compared. Complete attenuation of flick response to squid extract occurred as a result of (1) distilled water ablation of lateral flagella, (2) excision of aesthetascs and asymmetric sensilla, and (3) excision of aesthetascs. Distilled water ablation of medial flagella resulted in a mean flick rate 52% of that observed for sham-ablated lobsters toward squid extract. Flicking was unaffected by excision of asymmetric, guard, or companion sensilla. We propose that odorant mediation of flicking behavior requires both the aesthetasc and nonaesthetasc pathways.
Genetic origins of cataract.

Cataract, which can be defined as any opacity of the crystalline lens, results when the refractiveindexofthelensvariessignificantlyoverdistancesapproximatingthewavelength of the transmitted light. 1 This variation in the refractive index can result from changes in lens cell structure, changes in lens protein constituents, or both. 2 Cataracts are generally associated with breakdown of the lens microarchitecture. Vacuole formation can cause large fluctuations in optical density, resulting in light scattering. Light scattering and opacity also can occur if there are significant concentrations of high-molecular-weight protein aggregates,roughly0.1nmormoreinsize. Theshort-range,orderedpackingofthecrystallins,which make up more than 90% of soluble lens proteins, is important for the maintenance of lens crystallins in a homogeneous phase.
A conversation with Joseph Lau

Dr. Joseph Lau is a world‐leading expert in meta‐analysis and systematic reviews. Currently a professor in the Department of Health Services, Policy and Practice and co‐director of the Center for Evidence‐based Medicine at Brown University, Professor Lau has applied evidence‐based methods to a variety of clinical, biomedical and healthcare topics; has developed reliable and efficient methods and tools to conduct systematic reviews and meta‐analyses; and has advanced an understanding on the impact of factors that may contribute to differences of results in scientific studies. His past research includes cumulative meta‐analysis of randomized controlled trials, comparison of results from large trials and meta‐analyses of small trials, effect of baseline risk in the interpretation of clinical trial results, and empirical evaluation of existing methods of combining data. His current focus is on a Web‐based repository of systematic review data, reviews of diagnostic tests, nutrition, clinical practice guidelines, and dissemination of evidence‐based methods to varied health‐care disciplines. This report is a conversation from an adapted version of an interview, more or less chronologically arranged, between Joseph C. Cappelleri as interviewer and Joseph Lau as interviewee, with Meghan Ingerick recording and transcribing the interview. Copyright © 2014 John Wiley & Sons, Ltd.
Evaluating greenhouse gas impacts of organic waste management options using life cycle assessment

Efforts to divert organics away from landfills are viewed by many as an important measure to significantly reduce the climate change impacts of municipal solid waste management. However, the actual greenhouse gas (GHG) impacts of organics diversion from landfills have yet to be thoroughly evaluated and whether such a diversion provides significant environmental benefits in terms of GHG impacts must be answered. This study, using California-specific information, aimed to analyse the GHG impacts of organics diversion through a life-cycle assessment (LCA). This LCA considered all aspects of organics management including transportation, materials handling, GHG emissions, landfill gas capture/utilization, energy impacts, and carbon sequestration. The LCA study evaluated overall GHG impacts of landfilling, and alternative management options such as composting and anaerobic digestion for diverted organic waste. The LCA analysis resulted in net GHG reductions of 0.093, 0.048, 0.065 and 0.073 tonnes carbon equivalent per tonne organic waste for landfilling, windrow composting, aerated static pile composting, and anaerobic digestion, respectively. This study confirms that all three options for organics management result in net reductions of GHG emissions, but it also shows that organics landfilling, when well-managed, generates greater GHG reductions. The LCA provides scientific insight with regards to the environmental impacts of organics management options, which should be considered in decision and policy-making. The study also highlights the importance of how site and case-specific conditions influence project outcomes when considering organic waste management options.
Identification of Regulatory Factor X as a Novel Mismatch Repair Stimulatory Factor*

This report describes the identification and purification of a novel mismatch repair stimulatory factor from HeLa cell extracts. This activity copurifies with a proliferating cell nuclear antigen-dependent 5 ′ → 3 ′ DNA excision activity during several purification steps but is resolved from the excision activity during gel filtration chromatography using Sephacryl S-300. After purification to near homogeneity, the stimulatory factor is associated with three polypeptides with apparent molecular masses of 68, 36, and 30 kDa. Peptide sequencing analysis by tandem mass spectrometry identified the stimulatory factor as the heterotrimeric regulatory factor X (RFX) complex, which regulates transcription of the class II major histocompatibility complex by facilitating histone acetylation and is defective in the human hereditary immunodeficiency syndrome called bare lymphocyte syndrome. This conclusion was confirmed by the facts that purified recombinant RFX stimulates mismatch repair in an in vitro reconstituted mismatch repair system and that depletion of RFX from nuclear extracts or RFX knockdown in cells reduces mismatch repair activity. As expected, RFX knockdown cells display instability in microsatellite sequences. The possible role of RFX in human MMR repair is discussed.
Protein kinase G signaling in cardiac pathophysiology: Impact of proteomics on clinical trials

The protective role of cyclic guanosine monophosphate (cGMP)‐stimulated protein kinase G (PKG) in the heart makes it an attractive target for therapeutic drug development to treat a variety of cardiac diseases. Phosphodiesterases degrade cGMP, thus phosphodiesterase inhibitors that can increase PKG are of translational interest and the subject of ongoing human trials. PKG signaling is complex, however, and understanding its downstream phosphorylation targets and upstream regulation are necessary steps toward safe and efficacious drug development. Proteomic technologies have paved the way for assays that allow us to peer broadly into signaling minutia, including protein quantity changes and phosphorylation events. However, there are persistent challenges to the proteomic study of PKG, such as the impact of the expression of different PKG isoforms, changes in its localization within the cell, and alterations caused by oxidative stress. PKG signaling is also dependent upon sex and potentially the genetic and epigenetic background of the individual. Thus, the rigorous application of proteomics to the field will be necessary to address how these effectors can alter PKG signaling and interfere with pharmacological interventions. This review will summarize PKG signaling, how it is being targeted clinically, and the proteomic challenges and techniques that are being used to study it.
Pulsed-Vdd: Synchronous circuit design without clock network

Almost all digital circuits designed these days are synchronous ones. A clock is responsible for synchronization and is distributed via clock (distribution) network, which requires significant design time and effort and incurs extra area and wirelength. We advocate that synchronous circuit can be designed without clock network. Instead, power supply Vdd network is made to carry periodic negative pulses. A new sequencing element is proposed, which internally generates a positive pulse with each negative pulse on Vdd and then latches input data using that pulse. Since pulses are delivered over the Vdd network, which inherently has small RC value, skew becomes smaller, which is another advantage.
Threat Perception Bias and Anxiety Among Chinese School Children and Adolescents

This study evaluated the relationship between threat perception bias and anxiety among children and adolescents in China. A sample of 1,004 elementary, middle and high school students aged 9 to 19 years listened to stories containing themes of generalized anxiety, social anxiety and separation anxiety in either an ambiguous or non-ambiguous context. The story content included topics such as upset stomach, teacher-student interaction, and parents who are late to return home. Multiple threat perception indices were derived from children's responses. Children's level of anxiety was assessed by means of self-report questionnaires and parental reports. Higher levels of anxiety were related to higher frequencies of threat perception and interpretation, lower thresholds to detect threat and more negative feelings and cognitions. Age and gender were also related to some indices of threat perception bias. Threat perception bias was related to anxious symptomatology in general and was not content specific to particular anxiety disorders. The findings were consistent with studies conducted in Western culture and suggest that cognitive processing theories of childhood anxiety may generalize beyond Western society.