Miracle-dz/UniFAR-FTUs huggingface dataset:
Knowledge management in the pharmaceutical industry between academic research and industry regulations

ABSTRACT The pharmaceutical sector is one of the pillars of the world’s economy. A significant proportion of its value lies in intellectual assets generated through continuous innovation and lengthy development cycles within a strictly regulated environment. The purpose of this paper is to address the gap between knowledge management (KM) as an expanding academic discipline in the pharmaceutical industry and at the same time a growing regulatory expectation. A systematic review of 137 refereed KM articles revealed six empirical research themes in the pharmaceutical industry. In a subsequent step, the discovered themes and subthemes were compared with the extant regulatory expectations as explained in 128 regulatory guidelines. Findings shed the light on the gap between academic KM research and the current thinking of regulatory bodies. Some regulated knowledge processes were underrepresented in academic literature. The paper offers also novel insights and recommendations for future developments in academic research, regulations, and/or industry.
J48-Based Algorithm in Predicting the Success Rate in the Board Examination

J48 algorithm was utilized in this study to predict the performance rate in the Board Examinations for Teachers Education program (LET) of the secondary teacher education graduates. To develop the model, the raw scores in the college entrance examination as well as the general average (GA) in the core subjects, professional subjects, and common subjects were considered. Likewise, the performance in the LET review and in the actual LET Board, whether pass or fail were also taken into consideration. A total of 348 examples was deliberate came from 2012 to 2017 list of graduates. The pruned tree summed up to 16 utilizing 10 leaves. The Kappa value was established to be 0.8195 meaning an almost perfect agreement. In other words, all of the categorized instances by the researcher-developed J48-based academic analytics model had closely matched the actual count data. Hence, predicted failures, could be promptly given appropriate intervention programs by the dean and the professors in order to enhance the scores and GA of students. By so doing, the success rates in the LET will be improved. The J48 algorithm was tested at Aklan State University (ASU) [1] due to the absence of a data-mining system that could predict success in the LET. Therefore, the sets of data used in this study were from ASU specifically in Kalibo Campus. In its entirety, this study might help in determining the success rates of graduates in the LET that could eventually help in the accreditation of teacher education programs.
Identification and Analysis of microRNAs Responsive to Abscisic Acid and Methyl Jasmonate Treatments in Persicaria minor

Persicaria minor has been recognised as a plant with high content of volatile organic compounds (VOC) especially terpenoid and green leaf volatile (GLV). Previous finding had showed signaling molecules such as abscisic acid (ABA) and methyl jasmonate (MeJA) can increase the VOC content in plant. In this study, we performed next generation sequencing (NGS) of small RNA to uncover miRNAs roles and their response to both phytohormones (ABA and MeJA) in P. minor. For both ABA and MeJA treated P. minor, small RNA libraries containing 17,253,566 and 40,437,576 reads were generated, respectively. In addition, 18,634,904 reads were generated in plant treated with sterile distilled water which served as control. In these libraries, a total of 88 miRNAs were identified, comprising 41 known and 47 novel miRNAs. It was observed that 21 and 38 miRNAs were significantly regulated in ABA and MeJA libraries, respectively. Four selected miRNAs related to VOC pathways were subjected to RT-qPCR analysis and found to display diverse expression patterns with their targets. This study provides the initial framework for further exploration of miRNA roles in ABA and MeJA responses.
Adaptation and the Parliament of Genes

Fields such as behavioural and evolutionary ecology are built on the assumption that natural selection leads to organisms that behave as if they are trying to maximise their fitness. However, there is considerable evidence for selfish genetic elements that change the behaviour of individuals to increase their own transmission. How can we reconcile these contradictions? We found theoretically that: (1) when selfish genetic elements have a greater impact at the individual level, they are more likely to be suppressed, and suppression spreads more quickly; (2) selection on selfish genetic elements leads to higher levels of distortion, making them more likely to be suppressed. Overall, our results suggest that selfish genetic elements will either have a minor impact at the individual level, or tend to be suppressed, and that selection on selfish genetic elements will often drive their own suppression.
Selective reductions using visible light photocatalysts of supported gold nanoparticles

Photocatalytic synthesis using visible light is a desirable chemical process because of its potential to utilize sunlight. Supported gold nanoparticles (Au-NPs) were found to be efficient photocatalysts and the effects of the supports were identified including CeO2, TiO2, ZrO2, Al2O3, and zeolite Y. In particular Au/CeO2 exhibited the high catalytic activity to reduce nitroaromatics to azo compounds, hydrogenate azobenzene to hydroazobenzene, reduce ketones to alcohols, and deoxygenate epoxides to alkenes at ambient temperatures, under irradiation of visible light (or simulated sunlight). The reac-tive efficiency depends on two primary factors: one is the light adsorption of catalysts and another is the driving ability of catalysts corresponding to the reactants. The light absorption by Au-NPs is due to surface plasmon resonance effect or inter-band electron transition; this is related to the reduction ability of the photocatalysts. Irradiation with shorter wavelengths can excite the conduction electrons in Au-NPs to higher energy levels and as a result, induce reduction with more negative reduction potentials. It is known when irradiated with light the Au-NPs can abstract hydrogen from isopropanol forming Au-H species on the Au-NP surface. Hence, we proposed that the active Au-H species will react with the N=O, N=N, C=O double bonds or epoxide bonds, which are weakened by the interaction with the excited electrons in the Au-NPs, and yield the final reductive products. The reacting power of the Au-H species depends on the energy of the excited electrons in Au-NPs: the higher the electronic energy, the stronger the reduction ability of the Au-H species. This finding demonstrates that we can tune the reduction ability of the photocatalysts by manipulating the irradiation wavelength.
Mass Balance of the Greenland Ice Sheet from GRACE and Surface Mass Balance Modelling

The Greenland Ice Sheet (GrIS) is losing mass at a rate that represents a major contribution to global sea-level rise in recent decades. In this study, we use the Gravity Recovery and Climate Experiment (GRACE) data to retrieve the time series variations of the GrIS from April 2002 to June 2017. We also estimate the mass balance from the RACMO2.3 and ice discharge data in order to obtain a comparative analysis and cross-validation. A detailed analysis of long-term trend and seasonal and inter-annual changes in the GrIS is implemented by GRACE and surface mass balance (SMB) modeling. The results indicate a decrease of −267.77 ± 8.68 Gt/yr of the GrIS over the 16-year period. There is a rapid decline from 2002 to 2008, which accelerated from 2009 to 2012 before declining relatively slowly from 2013 to 2017. The mass change inland is significantly smaller than that detected along coastal regions, especially in the southeastern, southwestern, and northwestern regions. The mass balance estimates from GRACE and SMB minus ice discharge (SMB-D) are very consistent. The ice discharge manifests itself mostly as a long-term trend, whereas seasonal mass variations are largely attributed to surface mass processes. The GrIS mass changes are mostly attributed to mass loss during summer. Summer mass changes are highly correlated with climate changes.
Modeling of tree height–diameter relationships in the Atlantic Forest: effect of forest type on tree allometry

Tree height is one of the most important variables for quantitative assessment of forest stocks, but it is difficult to directly measure. Such allometric relationships of trees can vary between geographical regions, however, mainly due to climatic, edaphic, and floristic gradients. Based on the hypothesis that different forest types influence the generic modeling of tree height–diameter relationships on geographical scales, this study aimed to (i) fit equations to estimate tree height in Atlantic Forest types in the state of Rio de Janeiro, Brazil; (ii) compare efficiency and precision between generic and specific equations for forest types; and (iii) test the effect of different forest types and species on the height–diameter relationship. Four allometric models were tested for all forests (generic) and three main forest types (specific). Effects of tree size, forest types, and species on tree height estimation were analyzed using multiple linear models and mixed-effect linear models. A significant effect of forest type and species on tree height was seen, showing the need to apply local specific equations to minimize the effects that are not captured by generic equations. Differences in tree allometry between forest types were associated with temperature, rainfall, soil, and forest structure. These results confirm the effect of the local environment on the height–diameter relationship of trees as found over large scales in tropical forests.
Kualitas Udara Selama Perjalanan di Kapal Motor Camara Nusantara 3

The Camara Nusantara Ship is a mode of transportation used for transporting cattle to various islands. The journey from Kupang, East Nusa Tenggara to Jakarta took five days. The gases that produced during the trip on the ship were ammonia, methane, carbon dioxide, and carbon monoxide. This aim of research to analysis the air quality of each deck on the ship during transportation and inform the threshold of gas concentration as well as strategies to improve air quality for livestock on the Camara Nusantara Ship. Measurements were taken three times: morning (8 am), noon (12 pm) and afternoon (4 pm). Observation of the gas concentration level was carried out for 10 - 15 minutes. The study was conducted observation, and data analysis was done descriptively. The results showed that the level of gas concentration still in the normal range and below the threshold value and the microclimate on the deck still in the normal range. Another factor that influence air quality were still in the safe category, namely wind speed. Strategies that can be applied to anticipate the decline in air quality by improving the ventilation system on the ship by focusing more on the engine airflow on the vessel.
ÖRGÜTLERDE DENETİM İŞLEVİ VE ÇALIŞANLARDA DENETİM ALGISI: HAKKÂRİ EMNİYET MÜDÜRLÜĞÜ ÖRNEĞİ

Orgutler hayatlarini ve gelisimlerini surdurebilmeleri icin belirli islevleri yerine getirmelidirler. Bunlardan biri de kurulus amaclarina ulasip ulasmadiklarini ya da hedeflerine ne kadar yakinlastiklarini gormelerinde faydasi olan “denetim” islevidir. Dolayisiyla hiyerarsik olsun olmasin her orgutun bir denetim islevi vardir denilebilir. Denetim islevinin diger bir faydasi ise calisanlarin orgut amaclarina yonlendirilmesinde katki saglamasidir. Bu itibarla denetim islevi orgut yonetimleri tarafindan kabul edilebildigi gibi orgut calisanlari tarafindan da kabul edilebilmelidir. Guvenlik hizmetini yerine getiren polis orgutu de hiyerarsik yapisi ile denetim islevinin etkin oldugu orgutlerden biridir. Bu calismada polis memurlarinin, orgutlerinde var olan denetim islevini, ne yonde ve nasil algiladiklari tespit edilmeye calisilmistir. Bu kapsamda oncelikle denetim ve algi hakkinda kavramsal analize yer verilmis ve sonrasinda konu hakkinda daha onceden yapilan calismalar degerlendirilmistir. Kendine ozgu denetim islevi bulunan polis orgutu, yapisinda bulunan denetim sistemi ve araclari acisindan degerlendirilmis, muteakiben Hakkâri Emniyet Mudurlugu’nde gorev yapan polis memurlari uzerinde yapilan anket calismasina yer verilmis ve elde edilen bulgular analize tabi tutulmustur. Calisma sonucunda mesleki yorgunluk ve stres ile denetim algisi arasinda ters yonlu bir iliski, denetimi yapanin yeterliligi ile denetim algisi arasinda dogru yonlu bir iliski oldugu anlasilmistir.
Effects of self-regulation scaffolding on online participation and learning outcomes

Abstract The aim of this study is to investigate whether an interactive self-regulation scaffolding increases levels of online learners’ self-regulated learning skills, course participation, and learning performance. The intervention utilizes a dialog approach with an intelligent conversational agent to scaffold learners’ self-regulated learning. Fifty-six graduate students participated in this study over a semester and were randomly assigned to one of two conditions: (1) an experimental condition where a scaffold was provided through the conversational agent and (2) a control condition where the self-regulated learning information was given, but any scaffolds were not provided. The results revealed that the scaffolded group showed higher self-regulated learning level gains than the control group. Additionally, the relationships between self-regulated learning, course participation, and learning performance were investigated.
Integrating reproductive phenology in ecological niche models changed the predicted future ranges of a marine invader

Phenology of a wide diversity of organisms has a dependency on climate, usually with reproductive periods beginning earlier in the year and lasting longer at lower latitudes. Temperature and day length are known environmental drivers of the reproductive timing of many species. Hence, reproductive phenology is sensitive to warming and is important to be considered for reliable predictions of species distributions. This is particularly relevant for rapidly spreading non‐indigenous species (NIS). In this study, we forecast the future ranges of a NIS, the seaweed Sargassum muticum, including its reproductive phenology.
Enrichment of Different Plant Seeds with Zinc and Assessment of Health Risk of Zn-Fortified Sprouts Consumption

Zinc (Zn) is a nutrient that regulates many vital functions of the human body, hence the demand for Zn in the balanced daily nutrition has to be covered. Priming of seeds with Zn for Zn-enriched sprout production can be considered a good alternative to artificial supplementation in a modern diet. Hence, the aim of our study was to determine the exposure level of Zn bringing neither risk for humans nor growth inhibition of enriched broccoli, pea and sunflower sprouts. Seeds treated with 0, 10, 20 and 30 μg mL−1 ZnSO4 responded in a differentiated way to Zn. Pea seed germination and sprout growth was diminished by 30 μg mL−1 ZnSO4, but for sunflower sprouts this Zn level resulted in the highest fresh mass and largest hypocotyls. Zn content in sprouts greatly increased in a dose-dependent manner, mostly in broccoli (up to 25 times) and peas (up to 4 times), and to a lesser extent (up to 120%) for sunflowers. Free radical scavenging activity was usually decreased. Considering the potential non-carcinogenic risk of sprouts consumption estimated by the hazard analysis, the safest exposure level for seed priming will be 10 μg mL−1 ZnSO4. It was confirmed by random amplification of polymorphic DNA analyses indicating no DNA variations in sprouts treated with 10 μg mL−1 ZnSO4 compared to the control.
Family Environment In Rural China And The Link With Early Childhood Development

ABSTRACT In this study, we investigate the association between family environment and early childhood development among children aged 6–24 months in rural counties in China. To do this, we used cross-sectional data from a large scale survey, including 1809 child-caregiver dyads across 22 nationally designated poverty counties. We found that 53.95% of children were at the risk of cognitive development delay, 60.26%, 36.27%, 40.69% of children were at the risk of language, motor, and social-emotional development delay respectively. Moreover, the good quality of family environment was significantly associated with the child’s development. Rural family environments are providing insufficient stimulation for children, especially a low variety of developmental enriching materials and lacking play activities. Our study confirms the need for programmatic interventions that provide reliable ways to learn how to play with their children and build a stimulating environment to improve early childhood development in the region.
mHealth In Comprehensive Geriatric Service- The Way Forward

The projected increase in the number of disabled older persons poses a challenge for health care and social services. (1) Multiple health problems of such people will require an integrated approach. (2) While the elderly have unique assessment needs, these are often not addressed adequately. Usually only the presenting illness of the elderly are adequately addressed and the ‘Non-medical’ & ‘Non-presented’ issues are not looked into. Many of these issues are not presented to the treating physician as patients & families presume that these are part of normal aging. The importance of comprehensive geriatric assessment is that, it permits a systematic evaluation & documentation of all the issues that concern this population and identification of problems could lead to implementation of corrective and or preventive measures. There is evidence to suggest that a variety of M health techniques can be applied effectively and safely in geriatric medicine in providing comprehensive geriatric service across a variety of clinical settings.
Aplicación de Quitosano con Aceites Esenciales contra Botrytis cinerea Pers. “Moho Gris” en Lycopersicon esculentum P. Mill “Tomate”

The aim of this study was to determine the efficacy of the application of chitosan and essential oils of Citrus aurantifolia and Origanum vulgare to prevent infections by Botrytis cinerea, which causes gray rot in tomato. The effects of the coatings on the sensory characteristics of the tomatoes were also evaluated. All concentrations tested in vitro of AEOV (10 μL / mL, 5 μL / mL, 2.5 μL / mL and 1.25 μL / mL) and QUI (4 mg / mL and 8 mg / mL) resulted in 100% MGI for B. cinerea. Otherwise, AECA 20 μL / mL originated values between 40-47% ICM. The application of coatings comprising QUI 4 μL / mL + AEOV 5 μL / mL significantly decreased the infection severity of gray rot in tomatoes artificially contaminated with B. cinerea. The IS in tomatoes treated with the combinations of chitosan and essential oils was similar or lower than that observed in the tomatoes treated with synthetic fungicide (Iprodione 0.8mg / mL + Myclobutanil 0.1 mg / mL). The coatings comprising chitosan and essential oils preserved the sensorial quality of the tomatoes. These results suggest that the coatings composed of QUI and AEOV could become a promising alternative treatment for various fruits and foods due to their natural character, the improved antimicrobial activity and to not develop resistance in pathogens.
Spatio-temporal structure of single neuron subthalamic activity in Tourette Syndrome explored during DBS procedures

Basal ganglia dysfunctions have been suggested to play a causal role in the pathophysiology of most motor and non-motor symptoms of movement disorders as Tourette Syndrome (TS) or Parkinson’s Disease (PD). Intra/post-operative recordings from the subthalamic nucleus (STN) during Deep Brain Stimulation (DBS) procedures in PD patients have highlighted specific pathological patterns of neural activity. Spatial and temporal patterns of STN neural activity in TS are still unknown due to the lack of direct microrecordings in humans. Here, we describe for the first time specific neural activities of sensorimotor STN in TS patients, as recorded during intraoperative microrecordings. We analyzed 125 single units at 0.5 mm-spaced depths from the STN of anesthetized TS patients and we observed a large fraction of units (39/125, 31.2%) intensely bursting in the delta band (<4 Hz). In anesthetized PD patients we found similar average firing rate and spectral density of STN units, but differently to TS patients, only 4/54 (7.4%) of the units displayed bursting. Remarkably, bursting units in TS STN were not homogeneously distributed over the dorso-ventral trajectory of the recording: the highest density of bursting units was reliably found at the depth for which the clinical effect was maximal. Our results provide an unprecedented characterization of STN functional architecture and single units dynamics in TS patients, paving the way to an understanding of the role of STN subterritories in TS. Key Points Single neuron activity in Subthalamic Nucleus (STN) of patients with Tourette Syndrome (TS) was analyzed for the first time in literature. Firing rate and spectral content of single STN neurons in TS patients were found to be similar to those of anesthetized PD patients, while the analysis of arrhythmic bursting activity revealed that in TS patients the STN is characterized by a larger fraction of bursting neurons and more intense bursts Bursting activity in TS was widespread across the whole STN, but with a higher density at the optimal lead location depth for DBS
Effect of Phase Distribution on the Antibacterial Property and Cytotoxicity of Ti-5Al-2.5Cu Alloy after Heat Treatment at Various Temperatures

Titanium alloys are widely employed for the fabrication of biomedical devices. In this study, we designed and developed a Ti-5Al-2.5Cu alloy, which exhibited antibacterial properties. Microstructure and elemental analyses were performed using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and transmission electron microscopy (TEM). We evaluated the alloy’s antibacterial properties using Escherichia coli in the plate-count method. The cytotoxicity was examined using the MG-63 cell response by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays. Microstructural analysis revealed that Ti-5Al-2.5Cu exhibited an equiaxed α’ martensite structure after short-term annealing. The heterogeneous and homogeneous α → α + Ti2Cu phase transitions occurred at ~840 and 920 °C, respectively. The antibacterial property for Ti-5Al-2.5Cu was varied by volume fraction in the Ti2Cu and Cu-rich phase, which was obtained using different heat treatments. The high volume fraction of the Ti2Cu and Cu-rich phase was observed after long-term annealing at 720–840 °C and thus exhibited a higher antibacterial rate. The relationship between phase distribution and the antibacterial property could be satisfied by a positive linear regression equation. Cytotoxicity results showed that heat treatments at different temperatures for Ti-5Al-2.5Cu alloys had no effect on cell viability. The optimal heat treatment for Ti-5Al-2.5Cu alloy was annealing at 760 °C for 24 h. After, the alloy exhibited both promising antibacterial performance and good cytocompatibility.