Miracle-dz/UniFAR-FTUs huggingface dataset:
Fentanyl analytics in a case of fatal misuse of tra nsdermal fentanyl

A 54-year old male (90 kg) was found in his bedroom with a fentanyl transdermal patch on his penis. Wi th low vital reactions, the dormant man was immediately br ought to hospital, where he died shortly. Systemati c toxicological analysis confirmed a fatal poisoning with f entanyl. The fentanyl concentration in blood was 35 . 1 µg/L (LC-MS-MS). The presented case demonstrated the possibility of fentanyl misuse with a transdermal patc h at a place of possibel high resorption and fatal outcome . Death due to the application of fentanyl transder mal system which was patched on the penis has not been previou sly reported.
Existence of Notoriety Bias in FDA Adverse Event Reporting System Database and Its Impact on Signal Strength

Background: Notoriety bias is defined as “a selection bias in which a case has a greater chance of being reported if the subject is exposed to the studied factor known to cause, thought to cause, or likely to cause the event of interest. ” This study aimed to determine the existence of notoriety bias in the FDA Adverse Event Reporting System (FAERS) database and estimate the impact of potential notoriety bias induced by safety alerts on signal estimation using disproportionality analysis. Methods: Publicly available FAERS data were downloaded and used for analysis. Thirty-one drugs which had label change/safety alert issued by FDA from 2009 to 2013 were considered. These drugs were reviewed 4 quarters before and after the safety alert notification for the existence of notoriety bias. The impact of notoriety bias induced by safety alerts was analyzed by comparing the signal strength using reporting odds ratio (ROR) and proportional reporting ratio (PRR), 2 years before and after the safety alert. Wilcoxon signed rank test was used to determine whether there were a statistically significant difference before and after the safety alert. Results: There was increased reporting for 11 drugs after the safety alert/label change by the FDA. The reporting of 20 drugs decreased or remained unchanged after the safety alert/label change by the FDA. Wilcoxon signed rank test showed that there is no statistically significant difference with respect to the number of reports before and after the safety alert (P = .330, Z = −0.974). Fourteen (45.16%) drugs had an increase in ROR, while 17 (54.83%) drugs had a decrease in ROR after safety alert issued by FDA (P = .953, Z = −0.059). Fourteen (45.16%) drugs had an increase in PRR, while 17 (54.83%) drugs had a decrease in PRR after safety alert issued by the FDA (P = .914, Z = −0.108). Conclusion: Although few FDA safety alert/warnings had a strong and immediate impact, many had no impact on reporting of AE and signal strength. This study found that overreporting due to notoriety bias does not exist in the FAERS database and the overall disproportionality in signal estimates is not altered by the safety alert.
Reoperations after total correction of tetralogy of Fallot Fallot tetralojisi onar›m› sonras› yeniden ameliyat gerektiren olgular

Background: Although the immediate results of definitive repair for tetralogy of Fallot (TOF) are excellent, it is known that some patients require a second or even third operation. The aim of this study was to analyze the indications, surgical procedures, and clinical outcomes of patients undergoing reoperation. Methods: Between 1985 and 2003, 211 patients underwent corrective repair for TOF in our clinic. Of these, 12 patients (%5.6; 7 females, 5 males; mean age 14.4±5.6 years; range 6 to 25 years) required reoperation. In all the patients, indication for reoperation was residual ventricular septal defect (VSD). Additionally, five patients had severe right ventricular outflow tract (RVOT) obstruction, and one patient had severe pulmonary regurgitation. At the reoperation, a new patch was placed to close the residual VSD in seven patients, and the former patch was repaired with pledgeted sutures in the remaining five. A pulmonary xenograft was implanted in the patient with severe pulmonary valve insufficiency. The mean follow-up after reoperation was 48.4±9 months. Results: There was no operative mortality. The only perioperative complication was injury to the right ventricle during sternotomy in one patient. One patient underwent a third operation for recurrent VSD due to infective endocarditis. Functional status was NYHA class I in eight patients, and class II in three patients. On final evaluations, there was no residual VSD or pulmonary regurgitation. The only mortality occurred due to a massive cerebral hemorrhage in the patient who underwent a third operation. Conclusion: For patients presenting with residual VSD or RVOT problems after correction of TOF, a reoperation should be considered in case progressive right ventricular failure and clinical deterioration develop. Reoperations are effective in relief of residual VSDs and RVOT pathologies and offer good mid-term results.
Development of an Elderly Telecare System

In this project, a smart elderly home monitoring system (SEHMS) has been designed and developed. The system consists of three modules which are the telecare system, telehealth system and monitoring system. This paper focuses on the discussion on the development of the telecare system and how it is integrated with the monitoring system to monitor elderly or chronically ill patients. The telecare system consists of two types of devices which are the panic buttons and the presence detectors. The panic buttons can be installed in the strategic area in the house which enables the elderly or individual with disability to call for help when communicating an emergency. Presence detectors are installed under or around the bed to detect the presence of the elderly. The monitoring system behaves as the heart of the overall system. When the telecare devices are triggered, it will send the alarm notification to care giver, social contact and/or emergency respond team via sms, emails or/and phone calls. With the developed system, elderly and chronically ill patients could stay independently in their own home with care facilities and secure in the knowledge that they are being monitored.
De Novo CHRNE Mutation: Congenital Myasthenic Syndrome

Ad dress for Cor res pon den ce Hande Gazeteci Tekin MD, İzmir Çiğli Regional Training Hospital, Clinic of Pediatric Neurology, İzmir, Turkey Phone: +90 505 598 56 81 E-mail: gazetecihande@yahoo.com. tr ORCID: orcid.org/0000-0002-4407-164X Re cei ved: 09.09. 2018 Ac cep ted: 23.01. 2019 1İzmir Çiğli Regional Training Hospital, Clinic of Pediatric Neurology, İzmir, Turkey 2Ege University Faculty of Medicine, Department of Pediatric Neurology, İzmir, Turkey Hande Gazeteci Tekin1, Sanem Yılmaz2, Gül Aktan2, Sarenur Gökben2
The Effect of A Four-Week Acute Vitamin C Supplementation on The Markers of Oxidative Stress and Inflammation Following Eccentric Exercise in Active Men

Aim:The purpose of the present research was to examine the effect of a 4-week acute vitamin C supplementation on the markers of oxidative stress and inflammation after an eccentric exercise session in active men. Materials and Methods: 20 non-athlete men (24.15 ± 1.75 years, 23.44 ± 7.16 body fat percentage, and VO2 max of 49.56 ± 2.16 mL/kg/min) volunteered for the study and were randomly assigned to vitamin C supplementation (1000 mg per day) and placebo groups. After 4 weeks of supplementation, all the subjects participated in an aerobic exercise session consisting of running on a treadmill at -10° incline and 80% VO2 max with 2-minute rests between sets. Blood samples were collected before and after supplementation and after exercise. Normalized data were analyzed in SPSS using repeated measures ANOVA, Bonferroni test, and independent samples t-test at the 0.05 significance level. Results: The results showed that acute vitamin C supplementation before (P = 0.005) and after exercise (P = 0.0001) significantly increased antioxidant capacity. It also prevented post-exercise increase in malondialdehyde (P = 0.001) and creatine kinase levels (P = 0.0001). Conclusion: Four weeks of acute vitamin C supplementation increases serum total antioxidant capacity which prevents exercise-induced oxidative stress and high increase in serum creatine kinase levels in active men.
Morbidity and mortality in colorectal surgery

The aim of the study was to determine the factors o f morbidity and mortality of colorectal surgery in a visceral surgery service. In a prospective study pe rformed from 15 December 2008 to September 15, 2009, the authors recorded all patients who underwe nt colorectal resection. They studied the morbidity and mortality rates using the 4 risk factors identi fied by the French Association of Surgery (AFC) criteria. Sixty-two patients were included in the s tudy. There was a slight male predominance (sex ratio=1.14). The median age was 67.76 years (range 37-89 years). The patients were operated mainly for colorectal cancer. The postoperative course was com plicated in 17 cases (morbidity = 27.4%). None of the criteria of morbidity of colorectal surgery was verified. The overall mortality rate was estimated at 11.29%. Only the age criterion (age> 70 years) was significantly checked as a criteria of colorectal surgery mortality (p <0.02). Advanced age is a fact or of mortality of colorectal surgery.
Alternative Oral Drugs to Pioglitazone in Type 2 Diabetes Mellitus.

Diabetes is a worldwide prevalent chronic disease with a significant disease burden and associated with many complications that significantly impact the quality of life. Pioglitazone has been a leading oral drug for the treatment of type 2 diabetes mellitus. However, recent studies reveal its association with increased bladder cancer risk with prolonged use. Due to this, alternative oral drug therapies have become the need of the hour. Currently available alternative drugs include α glucosidase inhibitors, incretins (GLP -1 agonists & DPP IV inhibitors), SGLT – 2 inhibitors, glitazars, meglitinides, dopamine agonists and bile acid sequesterants. Other agents currently in pipeline include GPR40 agonists, GPR119 agonists, Glucokinase activators, SPPARM’s ,11 β hydroxyl steroid dehydrogenase 1 inhibitors etc. This review aims to discuss alternative oral drugs to
CÂNCER COLORRETAL: ANÁLISE DO VALOR PROGNÓSTICO DO NÚMERO TOTAL DE LINFONODOS IDENTIFICADOS NA PEÇA DE RESSECÇÃO

RESUMO : Objetivos: Identificar possível valor prognóstico referente ao número total de linfonodos em espécime de ressecção de câncer colorretal, independentemente da existência de metástases linfonodais. Métodos: Foi realizada uma análise retrospectiva de uma série de 51 pacientes submetidos ao tratamento cirúrgico por adenocarcinoma colorretal, Dukes B ou C, pelo departamento de cirurgia do Hospital Municipal São José, em Joinville/SC, feita a correlação entre o número total de linfonodos identificados na peça cirúrgica com o estadiamento e a recorrência tumoral. Todos os exames anátomo patológicos foram realizados no mesmo laboratório. Resultados: Houve uma predominância dos tumores estágio Dukes B com 65% sobre os 35% de tumores Dukes C. O seguimento médio foi de 58 meses (6–102), o número de pacientes livres de doença é de 24 pacientes Dukes B (72%) e 12 Dukes C (66%). A contagem do número total de linfonodos identificados em espécimes de ressecção revelou uma média de 13,4 linfonodos por peça, com um valor médio de 12,2 e 15,7 linfonodos para os tumores Dukes B e C, respectivamente, (P<0.0001). Não foi observada diferença significativa em relação à média de linfonodos encontrados em pacientes livres de doença ou portadores de recidiva tumoral no grupo total (12.7x15;p=0.1) ou quando considerado o estágio Dukes B (11.4 X 14.1; p=0.3) ou Dukes C (15.2 X 16.6; p=0.3). Não foi também observada diferença significativa a respeito da relação entre linfonodos positivos e o número total de linfonodos nos pacientes com tumores Dukes C livres de doença ou com recorrência tumoral. Conclusão: Não foi possível identificar qualquer valor prognóstico para o número total de linfonodos identificados no que diz respeito ao estadiamento ou recorrência tumoral.
Immunadsorption und therapeutischer Plasmaaustausch

ZUSAMMENFASSUNG Die zur Verfügung stehenden Aphereseformen sind wirksame und komplementäre Therapieoptionen u. a. für die Behandlung unterschiedlicher Autoimmunerkrankungen. Neben dem therapeutischen Plasmaaustausch bedeutet die Immunadsorption einen wichtigen Fortschritt unserer Behandlungsmöglichkeiten. In vielen Bereichen der Medizin, insbesondere in der Nephrologie und der Neurologie, konnten autoimmunologische Mechanismen als Auslöser zahlreicher Erkrankungen identifiziert werden. Bei vielen dieser Krankheitsbilder stellt die therapeutische Apherese eine wertvolle Therapieoption dar, insbesondere bei ausgeprägter klinischer Symptomatik oder bei therapieresistenten Verläufen. Im Rahmen dieses Artikels wird auf den Einsatz der therapeutischen Apherese bei den wichtigsten nephrologischen und neurologischen Erkrankungen eingegangen.
Resultados Clínicos Tardios do Stent Farmacológico Liberador de Sirolimus Firebird® no Tratamento de Pacientes com Doença Arterial Coronária na Prática Diária – Seguimento de 24 Meses do Registro CLARIFIRE

Background: The Firebird sirolimus-eluting stent has proven to be effective in inhibiting neointimal hyperplasia in selected patients undergoing percutaneous coronary intervention. Our objective was to evaluate the performance and long-term outcomes of Firebird  in patients undergoing percutaneous coronary intervention in daily practice in Brazil. Methods: The CLARIFIRE Registry was a prospective, non-randomized, multicenter study enrolling 455 patients (536 lesions) in 14 Brazilian sites between December 2008 and May 2011. Clinical follow-up was performed at 1, 6, 12, and 24 months, and adverse events were adjudicated by the independent Clinical Events Committee. Results: Mean age was 61.1 ± 10.4 years, 30.8% were women, 41.9% had diabetes, and 58.2% had stable angina. The left anterior descending artery was the most prevalent target vessel (46.5%), 29.9% were restenotic lesions, and 8% were bifurcations. Six hundred and thirteen stents were implanted, and the mean nominal stent length and diameter were 22.0 ± 6.4 mm and 2.90 ± 0.40 mm, respectively. Procedural success was 97.6%. The cumulative major adverse cardiac events rate at 12 months (primary endpoint) was 8.1%. Considering post-discharge events up to 24 months (409/455), major adverse cardiac events were observed in 9.8%, cardiac death in 3.9%, and target vessel revascularization in 7.6% of the patients. Definite/probable stent thrombosis was observed in nine cases (2%) up to 30 days, and no further occurrences were found. Conclusions: The Firebird  sirolimus-eluting stent has demonstrated good performance and sustained safety and efficacy for patients treated in daily practice, as evidenced by the high procedural success rates and relatively low adverse event rates after 2 years.
Modification of graft survival by transfusion of the donor : a study in rats

textabstractThere is wide acceptance that in humans blood transfusions given to the recipient before grafting produce a strikingly beneficial effect on the post-transplant course of cadaveric or living related kidneys (Opelz eta! . 1981b: Salvatierra eta! . 1983). Recently it has been reported by several authors that blood transfusions to the donor prior to nephrectomy positively influence graft survival (Jeekel eta! . 1980: 1981: Frisk eta! . 1981: 1983: Harder eta! . 1984). However, retrospective studies by Berget a! (1982), Bock eta! (1984) and Opelz (1985a) could not confirm these reports. Many questions were raised by these retrospective observations and this made it necessary to experimentally investigate them in rigidly controlled studies. This thesis is the reflection of these experiments. Moreover. it contains an extensive introduction in the development of transplantation with special emphasis on the approaches to immune modulation in human kidney transplantation
Immune Depletion with Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in NOD Mice Running Title: ATG + G-CSF Reverses Overt Diabetes in NOD Mice

Objective — The autoimmune destruction of β cells in type 1 diabetes (T1D) results in a loss of insulin production and glucose homeostasis. As such, an immense interest exists for the development of therapies capable of attenuating this destructive process through restoration of proper immune recognition. Therefore, we investigated the ability for the immune depleting agent anti-thymocyte globulin (ATG), as well as the mobilization agent granulocyte-colony stimulating factor (G-CSF), to reverse overt hyperglycemia in the non-obese diabetic (NOD) mouse model of T1D. Research design and methods — Effects of each therapy were tested in pre-diabetic and diabetic female NOD mice using measurements of glycemia, regulatory T cell (CD4+CD25+Foxp3+) frequency, insulitis, and/or beta cell area. Results Here, we show that combination therapy of murine ATG and G-CSF was remarkably effective at reversing new onset diabetes in NOD mice, and more efficacious than either agent alone. This combination also afforded durable reversal from disease (>180 days post-onset) in animals having pronounced hyperglycemia (i.e., up to 500mg/dl). Additionally, glucose control improved over time in mice subject to remission from T1D. Mechanistically, this combination therapy resulted in both immunological (increases in CD4:CD8 ratios and splenic regulatory T cell frequencies) and physiological (increase in the pancreatic β cell area, attenuation of pancreatic inflammation) benefits.
Investigating Ground Reaction Forces and Electromyography Muscle Activity of Lower Extremity During the Stance Phase of Walking in Active Male with and Without Genu Varum Deformity in Kharazmi University in 2017: A Descriptive Study

Background and Objective: Genu varum is one of the most common knee deformities, which can cause changes in the forces of the body and the way the muscles of the lower limbs function due to changes in the mechanical axis of lower limb. The aim of this study was to investigate ground reaction forces and electromyography muscle activity of lower extremity during the stance phase of walking in subjects with and without genu varum deformity. Materials and Methods: In this descriptive study conducted in Kharazmi University in 2017, 30 active men were categorized into two groups of genu varum (n=15) and normal (n=15) based on their knee posture. The participants’ age ranged from 20 to 25 years. Using force plate and electromyography, respectively, ground reaction force and muscle activity were calculated. The data were analyzed utilizing independent samples t-test for between-group differences. Results: The findings indicated that the depth force of vertical ground reaction force in the normal group had significantly higher value compared to the genu varum group (p=0.018). Also, gluteus medius muscle during the loading response phase of walking in the active male with genu varum had significantly higher levels of activity than the control group (p=0.031). Conclusion: According to the findings of this research, it seems that mechanical deviation due to the deformity of the genu varum causes some changes in the ground reaction forces and the performance of the lower limb muscles during walking. The findings point to the need to pay attention to these factors in people with genu varum.
Estimating body fat from skinfold thicknesses in the elderly

1 Artigo elaborado a partir da dissertacao de C.R. RECH, intitulada “Validacao de equacoes antropometricas e de impedância bioeletrica para a estimativa da composicao corporal em idosos”. Universidade Federal de Santa Catarina; 2006. 2 Universidade Estadual de Ponta Grossa, Programa Pos-Graduacao em Educacao Fisica. Av. Ge Carlos Cavalcanti, 4748, Pca Santos Andrade, 84030-900, Ponta Grossa, PR, Brasil. Correspondencia para/Correspondence to: C.R. RECH. E-mail: . 3 Universidade do Vale do Itajai, Departamento de Nutricao. Itajai, SC, Brasil. 4 Universidade Federal de Santa Catarina, Programa de Pos-Graduacao em Educacao Fisica. Florianopolis, SC, Brasil. 5 Universidade Federal de Santa Catarina, Programa de Pos-Graduacao em Nutricao. Florianopolis, SC, Brasil. Utilizacao da espessura de dobras cutâneas para a estimativa da gordura corporal em idosos1
A Case History of the Recurrent Severe Oral Ulceration with the High Нelicobacter pylori Content in the Stomach.

The paper provides the detailed description of the medical case, the schedule of treatment of the recurrent severe oral ulceration in the patient with the high Нelicobacter рylori content in the stomach has been developed. For the fastest aphthae epithelialization, reduction of the recurrence rate, reduction of the patient’s complaints not only the local treatment is required but also the general treatment with agreement of the schedule with gastroenterologist, neurologist. The treatment of the recurrent oral ulceration associated with Helicobacter pylori shall be integrated, individualized, ethiopathogenic, substantiated, successive, dynamic, and symptomatic. Besides, performing the sparing professional prophylaxis during the first visit, sanation of the mouth cavity at the initial signs of epithelialization promotes to the prevention of re-infection of the stomach and oral mucosa with Нelicobacter рylori.
Proteasome inhibition with bortezomib (BORT) in combination with topotecan : A phase I solid tumor trial

14047 Background: Topoisomerase-I (Topo-I) down-regulation via the ubiquitin/26S proteasome pathway has been associated with drug resistance. We hypothesize that proteasome inhibition by BORT would enhance topotecan sensitivity by preventing down-regulation of topo-I. This phase I trial examined the safety and feasibility of combining weekly BORT with topotecan in patients (pts) with advanced solid tumors. Methods: Pts on 1 of 4 dose levels were treated with topotecan (3–4 mg/m2) IV and BORT (1–1.6 mg/m2) IV on days 1, 8, and 15. BORT was given 3 hours after topotecan based on preclinical studies (Flannery, 2003). Cycles were repeated q28 days. After 6 cycles, pts without progression could remain on BORT alone. Dose limiting toxicity (DLT) was defined as: grade (Gr) 4 platelets (plts) (<25K), Gr3 plts (<50K) with bleeding, febrile neutropenia, neutropenia with infection, Gr3 neuropathy, or any=Gr3 non-heme toxicity. Results: 15 pts were accrued. Pt characteristics: Median age 58 years (range 25–73); Male .
Application of microscopic techniques for the authentication of herbal medicines

Microscopic identification is the method most commonly used to authenticate Chinese herbal medicines. By means of various microscopic techniques, structural and cellular features of herbs are examined in order to determine their botanical origins and assess their qualities. This method is useful for identifying species from fragments or powders and for distinguishing species with similar morphological characters; it may also be useful for evaluating the pharmaceutical quality of herbs. In this chapter, techniques of preparing specimens for microscopic examination are described. Normal light microscopy combined with polariscope and fluorescence microscopy are introduced as they are used in the authentication of Chinese herbal medicines. Structures and cells of herbs have been found to possess stable and specific polariscopic and fluorescent characteristics that can be used to determine the botanical identify of herbal medicines. In addition, the future prospect of combining microscopes with chemical analysis to analyze the chemical profiles of herbal tissues is discussed. Establishing a correlation between microscopic features and active components distributed in a plant’s tissues will enable quality evaluation of Chinese herbal medicines by microscopy.