Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of national network and corporate networks (in the case of Tas-IX network)

This article is devoted to the development of the national data network of Uznet and Tas-IX, the history and development of Tas-IX, to improve the efficiency of using international communication channels, by excluding the transfer of local traffic over them. Strengthening the economic state of small and medium-sized businesses in the telecommunications sector by reducing their production costs for traffic transmission. The aim of the work is to directly contribute to the development of information and communication technologies in the telecommunications market of Uzbekistan. Promotes the development of the Uzbek Internet segment as a factor in the overall development of the society and raising the level of education in it, including by accessing the Internet resources of scientific, educational, state and business institutions
The role of DNA repair genes in mycobacterium tuberculosis pathogenesis.

Mycobacterium tuberculosis is an intracellular pathogen, able to survive and replicate in macrophages. Here the bacilli encounter host defences including the production of reactive oxygen intermediates (ROI) and reactive nitrogen intermediates (RNI). This is part o f the antimicrobial response, which amongst other targets can damage DNA. It is, therefore, highly important for the bacillus to maintain mechanisms with which to repair damaged DNA. Oxidatively damaged DNA bases are removed by a variety o f repair mechanisms, and studies in E. coli have identified genes that function within each of these pathways. M. tuberculosis homologues have been identified fi"om the genome sequence, and construction and characterisation o f strains defective in one or more of these genes has been used to assess the requirement for DNA damage repair in M. tuberculosis. Interestingly, strains containing individual mutations in a number of repair genes were affected in their ability to cause progressive infection in mice. In parallel with the mutational studies, global gene expression in wild-type M. tuberculosis and a recA mutant strain following DNA damage has been compared using microarrays. Generally, in bacteria DNA-damage inducible genes are regulated by the repressor protein LexA; this regulation is dependent on RecA. Thus, LexA-regulated genes are not induced in recA mutant strains. It was found that in M. tuberculosis the majority of DNA-damage inducible genes remained inducible in the recA mutant strain, including most o f the inducible DNA repair genes. This suggests that non-classical regulatory mechanism(s) are important for survival o fM tuberculosis following DNA damage.
Regional‐scale patterns of deep seafloor biodiversity for conservation assessment

Mining and petroleum industries are exploring for resources in deep seafloor environments. Lease areas are often spatially aggregated and continuous over hundreds to thousands of kilometres. Sustainable development of these resources requires an understanding of the patterns of biodiversity at similar scales, yet these data are rarely available for the deep sea. Here, we compare biodiversity metrics and assemblage composition of epibenthic megafaunal samples from deep‐sea benthic habitats from the Great Australian Bight (GAB), a petroleum exploration zone off southern Australia, to similar environments off eastern Australia.
Aproximação de alunas do ensino básico do pensamento computacional: relato de experiência de uma oficina de eletrônica

Este relato se refere ao ensino de conceitos computacionais possibilitados por meio da lógica, programação e eletrônica como um meio para a aproximação de meninas da área de computação, levando em consideração que, apesar do notável crescimento da participação das mulheres nas mais diversas esferas, a computação ainda é pouco populada pelas mesmas. De acordo com os resultados, este se mostrou um processo positivo no sentido de promover o despertar de interesses, a aproximação com as áreas de computação e eletrônica e a quebra de preconceitos.
Reduced Intensity Allogeneic Transplantation Provides High Disease-Free and Overall Survival in Patients (Pts) with Advanced Indolent NHL and CLL: CALGB 109901.

Reduced intensity allogeneic stem cell transplantation has been used increasingly to treat patients with both aggressive and indolent diseases such as low grade NHL and CLL. Most reports have consisted of single institution or registry data. We report here a prospective Cooperative Group study by CALGB in which 45 patients were treated at 11 CALGB institutions. Methods: Patients 40, DLCO > 40%, RNEF > 30% and LFTs 2 fludarabine × 5, and 1 gm/m 2 cyclophosphamide × 3. The graft was G-CSF mobilized PBSC, and tacrolimus and low-dose MTX (5 mg/m 2 ) on days 1,3,and 6 was used for GVHD prevention. Tacrolimus was tapered from day +90 to +150 in the absence of GVHD. Standard infectious disease prophylaxis, supportive care, and G-CSF from day +5 to engraftment were employed. DLI was given for stable or progressive disease, not loss of chimerism alone. Results: 47 pts were enrolled with 44 eligible and evaluable; median age 53; 23 NHL, 14 CLL, 2 PLL, 4 mantle cell and one unknown. 27% developed ≥ grade 2 acute GVHD and 47% (18% extensive) chronic GVHD. TRM at 6 months was 2% and was 7% overall. Mortality at 2.6 year f/u is 25% due to GVH, sepsis, or 2 nd malignancy (9%) and progressive disease (7 pts,16%). Estimated 2 yr DFS is 71% (CI 54–82) and OS is 76% (CI 60–87). Grade 4 AEs included 4 pneumonia/ pneumonitis, 1 PE, 1 VOD and 1 second malignancy (pancreatic CA). Documented infectious events included 32% viral, 41% bacterial, and 20% fugal. For T cell (CD3), the median chimerism at day 180 was 98% and 99% in peripheral blood and bone marrow; > 90% chimerism was present in 64% and 66% respectively. For unfractionated, the median chimerism at day 180 was 99% and 98% in peripheral blood and bone marrow; > 90% chimerism was present in 65% and 70% respectively. Conclusion: These encouraging results indicate that a high CR and DFS rate can be obtained with low TRM without use of anti-CD20 therapy in a Cooperative Group trial of matched related allogeneic transplant in patients with low grade NHL or CLL. Appropriate patients should be considered for such therapy when standard treatments are no longer capable of achieving prolonged remissions.
Hypercholesterolemia Prevalence, Awareness, Treatment and Control among the Elderly: The 2011 National Health and Morbidity Survey, Malaysia.

Aims: This study provides population-based estimates on the prevalence, awareness, treatment and control rates of hypercholesterolemia among the elderly in Malaysia. Study Design: Analysis of secondary data from a cross sectional population-based survey was done. Methodology: A total of 2764 respondents (15.5%) were selected in this study; the elderly subjects are from the secondary data analysis of 60 years and older. Results: The overall prevalence of hypercholesterolemia was 55.4%. The awareness rate for hypercholesterolemia was 39.5%. Out of those who were aware, treatment with medication was conferred to 77.7%. Control rate for hypercholesterolemia was 53.8%. Utilising multiple logistic regression analysis, factors associated with higher awareness rate of hypercholesterolemia were urban residents, secondary education level and Indian ethnicity; the factor associated with higher treatment rates was government/semi government employees; factors associated with higher control rate were males and Indian ethnicity. Conclusion: The overall prevalence, treatment and control rate of hypercholesterolemia among the elderly in Malaysia were high in comparison to awareness rate in this population.
Unique Markov Equilibrium Under Limited Commitment

I develop a recursive method for the characterization of competitive equilibrium under limited commitment with not‐too‐tight solvency constraints. The reputational mechanism is fragile, as it sustains constrained efficiency as well as a large set of constrained inefficient equilibria. However, I establish that the only strongly ergodic Markov equilibrium with trade is constrained efficient. The method relies on a planning program along with the theory of monotone concave operators. It is suitable for other applications to macroeconomics and dynamic contracts.
An investigation of the efficacy of training care home staff in a formulation based functional analysis approach to understanding stress and distress behaviours with dementia

Objectives: The aim of this study was to evaluate the outcome of a package of evidencebased person-focused training for formal carers working with people with dementia living in care homes. Specifically evaluating the efficacy of a new Formulation based Functional Analysis (FFA) approach to understanding stress and distress behaviours (SAD-behaviours) with dementia. Design: The study employed an open trial design, with three independent groups: two training interventions and a waiting list control. Method: Forty eight care staff were recruited from care homes across Cambridgeshire. Participants in intervention group one attended 15 hours of training (CAMTED), participants in intervention group two attended 21 one hours of training including a FFA module in understanding SAD-behaviours (CAMTED-Plus). The waiting list control consisted of staff waiting to receive training. All participants completed outcome measures on knowledge and attitudes to dementia, burden, job satisfaction and perceived frequency of SAD-behaviours and confidence in managing SAD-behaviours at baseline and post-intervention. Results: Due to the small sample size the waiting list group was excluded from data analyses. Results showed that there were no statistically significant differences between CAMTED and CAMTED-Plus on any of the outcomes at the end of the intervention. Within-group analyses of pre-post change found statistically significant differences for CAMTED in the degree of hopefulness about dementia and CAMTED-Plus in attitude to dementia, extent to which a person-centred approach is adopted and levels of depersonalisation. Positive feedback was provided on the use of the jigsaw training tool and verbal feedback indicated participants’ positivity about the training. Conclusion: The results provide preliminary support for the utility of the FFA approach as a training intervention. Although the results are limited due to the methodological shortcomings, they provide a range of evidence in support of the FFA approach, which may be built on in the future.
Metabolic syndrome in rural Kerala: a hospital based study

Background: Metabolic syndrome refers to a cluster of various interrelated cardio-metabolic risk factors that promote the development of atherosclerotic cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Identifying at risk individuals is necessary for early medical management, thereby reducing the economic burden on the patient and the society. The objective of this study was to assess the prevalence of metabolic syndrome in patients presenting to medicine clinics of our institute. Methods: This cross-sectional hospital based study was carried out at department of medicine, DM Wayanad institute of medical sciences, Wayanad, Kerala and included 432 patients attending the general medicine outpatient department. Patients’ demographic details and anthropometric measurements including height, weight, waist and hip measurements were taken. Clinical data including blood pressure, blood sugars and fasting lipid profile was also collected. The NCEP ATP III (National cholesterol education program - adult treatment panel III) criteria for diagnosis of metabolic syndrome were used to make a diagnosis of metabolic syndrome. Results: On applying the modified NCEP ATP III guidelines with the waist circumference specific to Asian population, we found that the prevalence of metabolic syndrome in our study population was 60.9%. The prevalence was more in females than in males and the difference was statistically significant (p = 0.049). Abdominal obesity and decreased HDL was more in females as compared to males and the difference was also found to be statistically significant. 27% of the study population with metabolic syndrome was normal or underweight. Conclusions: The prevalence of metabolic syndrome in the present studied population was high as they represent patients presenting to hospital. This data is more like the tip of an iceberg. Larger population based studies and intervention in the form of aggressive lifestyle modification is the need of the hour to prevent the cardio-metabolic complications of metabolic syndrome.
Marcadores Geoquímicos como Indicadores de Atributos Culturais na Paisagem Geomorfológica no Parque Nacional Serra da Capivara, Piauí-Brasil

Investigation about Prehistoric human occupation evidences using elemental chemical analysis have been an important tool in the study of archaeological sediments. In this perspective, we sought to further investigate the evidence of such occupation through geochemical markers in the Toca Sitio do Meio and Toca do Gordo do Garrincho sites, located in the Serra da Capivara-Piaui National Park, Brazil, and its surroundings. Therefore, a morphostratigraphic, sedimentological and geochemical study of deposits was carried out using physical, chemical and instrumental methods. The obtained data showed results for the soil texture determination, pointing to different clay minerals concentrations, influencing the phosphorus (P) fixation and other markers. The “P” element is present in all samples significantly, although it is not present in the parenting stuff, indicating that there was an allochthonous input, suggesting a strong evidence of the existence of human occupation levels. It should be considered that the climatic association between clay minerals and sediments should be taken more carefully, since it is observed that there is a great control of the rock. However, it was possible to establish theoretical and methodological parameters of environmental indicators with the application of geochemical markers for the indication of prehistoric human occupation levels and reconstruction of the dynamics and environmental evolution of Paleolandscapes.
Improving Bibliographic Coupling with Category-Based Cocitation

Bibliographic coupling (BC) is a similarity measure for scientific articles. It works based on an expectation that two articles that cite a similar set of references may focus on related (or even the same) research issues. For analysis and mapping of scientific literature, BC is an essential measure, and it can also be integrated with different kinds of measures. Further improvement of BC is thus of both practical and technical significance. In this paper, we propose a novel measure that improves BC by tackling its main weakness: two related articles may still cite different references. Category-based cocitation (category-based CC) is proposed to estimate how these different references are related to each other, based on the assumption that two different references may be related if they are cited by articles in the same categories about specific topics. The proposed measure is thus named BCCCC (Bibliographic Coupling with Category-based Cocitation). Performance of BCCCC is evaluated by experimentation and case study. The results show that BCCCC performs significantly better than state-of-the-art variants of BC in identifying highly related articles, which report conclusive results on the same specific topics. An experiment also shows that BCCCC provides helpful information to further improve a biomedical search engine. BCCCC is thus an enhanced version of BC, which is a fundamental measure for retrieval and analysis of scientific literature.
Prevalence of obesity and its correlates in school going adolescents of Haldwani, Nainital, Uttarakhand, India

Background: With a rising trend of Non-Communicable Diseases (NCDs) in the present world, overweight and obesity has gained importance as it is not only a disease in itself but also risk factor for majority of other NCDs. A dramatic increase in overweight and obesity among children and adolescent has raised the concern of various public health physicians especially in developing country like India. Aims & Objective: To study the prevalence of overweight and obesity & its correlates among school going adolescents of Haldwani block. Material & Methods: School based cross sectional study was done among the adolescents of 8th to 12th standard. To calculate the maximum sample size prevalence of obesity was assumed to be 50%, taking absolute error of 5%, design effect of 2 and 10% non-response rate the sample was calculated to be 880, rounded off to 900. Samples were collected from 30 clusters/schools using simple random sampling. Data was collected using a pre-designed, semi-structured and pre-tested questionnaire and analyzed by using SPSS version 22. Results: Prevalence of overweight and obesity was 13% (CI = 10.8 - 15.2%). Overweight and obesity was found to be significantly associated with urban area, private school, Socio-economic class I, non-vegetarian diet, physical inactivity and playing videogames, working on laptops and computer on univariate analysis. On applying binary logistic regression factors like private schools, socioeconomic class I, non-vegetarian diet and physical inactivity were again found to be significantly associated with overweight and obesity. Conclusion: Prevalence of obesity was found to be more in adolescents having modifiable risk factors.
Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes

Infections with Gram-negative bacteria form an increasing risk for human health, which is mainly due to the increase in antibiotic resistance. The cell envelope of Gram-negative bacteria consists of an inner membrane, a peptidoglycan layer and an outer membrane, which forms an impermeable barrier to many antibiotics and antimicrobial proteins. The complement system is an important factor of the human immune system that can efficiently kill Gram-negative bacteria via the formation of large pores in the bacterial outer membrane, called Membrane Attack Complexes (MACs). To better understand how these MAC pores damage the complex cell envelope of Gram-negative bacteria, we recently developed a fluorescent reporter system to study membrane damage in E. coli. Here, we used a similar experimental setup in combination with flow cytometry, confocal microscopy and conventional plating assays to elucidate how different components of the immune system act synergistically to effectively clear invading bacteria. We demonstrate how MAC-dependent outer membrane damage enhances the susceptibility of E. coli to further degradation of the cell envelope by lysozyme, leading to drastic changes in the morphology of these bacteria. Furthermore, we elucidate that the MAC enhances the susceptibility of E. coli to phospholipases, and to degradation and killing inside human neutrophils. Altogether, this study provides a detailed overview on how different players of the human immune system work closely together to degrade the complex cell envelope of Gram-negative bacteria. This knowledge may facilitate the development of new antimicrobials that could stimulate, or work synergistically with the immune system.
Blood Flow Velocity of the Middle Cerebral Arteries: A Real-Time Measure of Attentional Load in the Laparoscopic Surgery Environment?

Laparoscope (camera) rotations in laparoscopic surgery, and the resulting perceptual-motor distortions, increases the workload (attentional load) of surgeons. When attentional load is high, risks of surgical errors and patient injury increase. Blood flow velocity (BFV) changes of the middle cerebral arteries (MCAs) may serve as a real-time measure of attentional load in this environment. Seventeen undergraduates performed a laparoscopic training task (peg-transfer task) in a laparoscopic simulator at a non-rotated camera angle (0° condition−camera directly in front of the participant) and a rotated condition (camera was rotated 135° to the side). Performance (transfer speed) was superior in the 0° condition and performance in both camera conditions improved over time. Further, BFV was greater at the 135° rotation and declined over time in both conditions. The decline in BFV co-occurred with improved peg-transfer performance that occurred in both camera conditions. The results suggest that BFV changes of the MCAs are a sensitive indicator of attentional load induced by the perceptual-motor distortions inherent in laparoscopy. Thus, it may be possible to use BFV changes of the MCAs, a non-invasive measure, to assess real-time attentional load and attentional resource utilization in the surgical environment
L’USAGE DES OBJETS CONNECTES AU MAROC : VERS LA MISE EN PLACE D’UN MODELE CONCEPTUEL

Big Data, Intelligence Artificielle, Machine Learning, Chatbot, etc. Autant de concepts qui prennent de plus en plus de place dans notre quotidien et qui permettent de creer des produits et des services toujours plus innovants et personnalises. Ce passage accelere au tout digital qui a vu l'extension ces dernieres annees d'Internet a des choses et a des lieux du monde physique (Internet des Objets ou IdO), deplace encore plus le marketing traditionnel vers le marketing numerique, poussant deja certains auteurs a ne plus seulement parler de Marketing 2.0 ou 3.0, mais Marketing 4.0 (Kotler et al., 2017). Ainsi, et a travers la presentation des resultats d’une etude empirique, ce travail tente de mieux comprendre l’usage des objets connectes au Maroc, premiere etape vers la mise en place d’un modele conceptuel sur le sujet.
Auto-Resonant Tuning for Capacitive Power and Data Telemetry Using Flexible Patches

This brief proposes and demonstrates a reliable power and data transfer scheme for biomedical implants through a resonant capacitive link. Flexible, conformable, and biocompatible patches are adopted with an automatic resonant frequency calibration technique for the first time. A voltage feedback network, a Class-<inline-formula> <tex-math notation="LaTeX">${D}$ </tex-math></inline-formula> driver, and a custom algorithm have been developed for the low overhead calibration. An <italic>ex vivo</italic> chicken skin tissue-based experiment with 4 cm<sup>2</sup> flexible, conformal capacitive patches demonstrated the method. Experimental results show that the power delivered to the load (PDL) of the link extends up to 150 mW and maximum power transfer efficiency (PTE) of the link is 54%. A simultaneous data transfer with a rate of up to 170 kbps alongside power transfer using 1.5 to 2 mm-thick biological skin tissue has been achieved.
SOCIAL CONNECTIONS AND WELLBEING

Fears, attitudes, closeness of different social categories and media use were explored by through the Results of Oxford Happiness Inventory and Multiple Lickert scale. Findings include that happier individuals are better connected to their family, express positive stands on teachers, professors, sport workers and members of some nations. These notions are connected to results of previous research inquiries about wellbeing and increased agreeableness, increased extroversion, increased openness to experience and decreased neuroticism.