Miracle-dz/UniFAR-FTUs huggingface dataset:
H. pylori infection induces CXCL8 expression and promotes gastric cancer progress through downregulating KLF4

Tumour‐derived CXCL8 facilitates the movement of myeloid‐derived suppressor cells, which are able to restrain antitumour immune responses to the tumour microenvironment. Kruppel‐like factor 4 (KLF4) is a potential tumour suppressor in gastric cancer (GC). However, knowledge regarding correlations between KLF4 and CXCL8 in GC is limited. We use cellular and molecular biological methods to assess whether these two factors interact in GC. Expression CXCL8 and KLF4 was altered in human GC tissues compared to normal gastric tissues in opposite ways. Additionally, cytotoxin‐associated gene A protein (CagA) gene transduction or Helicobacter pylori (H. pylori) infection upregulated CXCL8 expression. Knockdown of KLF4 expression increased CXCL8 protein and RNA expression, whereas its overexpression had the opposite effect. CXCL8‐mediated enhancement of GC cell migration and proliferation was reversed by upregulation of KLF4 expression. Further mechanistic research revealed that KLF4 binds the CXCL8 promoter, suppressing CXCL8 transcription. Moreover, CXCL8 stimulation reduced KLF4 protein expression and promoted GC cell proliferation and migration, eventually promoting neoplasm growth in vivo. Together, our findings demonstrate that CagA promotes CXCL8 and inhibits KLF4. CXCL8 is a decisive downstream target gene of KLF4, and KLF4 negatively regulates CXCL8 in GC. Furthermore, CXCL8's negative regulation of KLF4 in vivo and in vitro, indicates that CagA may downregulate KLF4 by inducing CXCL8 expression, low expression of KLF4 further promotes that of CXCL8, forming a vicious circle in GC. Targeted KLF4 activation might improve the immunosuppressive microenvironment through direct negative regulation of CXCL8, providing a new potential target to strengthen the efficacy of immunotherapy in GC patients.
Discovery of GPX4 inhibitor by molecular docking simulation as a potential ferroptosis inducer

As one of the most complex diseases in the world, cancer continues as one of the significant public health problems. It was recorded by 2014 that cancer caused 1,551,000 death in Indonesia. One type of programmed cell death (PCD) that played a role in cancer cell treatment is Ferroptosis. Ferroptosis is PCD on iron and characterized by the inactivation of glutathione-dependent peroxidase (GPx4). In this research, a new therapeutic strategy for cancer was developed through the computational approach on synthetic compounds to discover its potential as an inhibitor of GPx4. About 688 compounds derivative from mercaptosuccinic acid acquired from the Zinc15 database. These compounds screened through the Lipinski’s Rule of Three and pharmacological prediction to eliminate ligands with undesired molecular properties. After that, the ligands underwent both rigid and flexible molecular docking simulations to predict their inhibition activity toward GPx4. From molecular docking simulation, (2S)-2-[(Z)-3-phenylprop-2-enyl]sulfanylbutanedioic acid show favorable characteristics as a drug candidate.
Understanding Hydrocarbon Adsorption in the UiO-66 Metal–Organic Framework: Separation of (Un)saturated Linear, Branched, Cyclic Adsorbates, Including Stereoisomers

The low coverage adsorption properties of alkanes, alkenes, and aromatics of the linear, branched, and cyclic type (ca. 70 molecules) were studied using inverse pulse gas chromatography at zero coverage on the zirconium metal–organic framework UiO-66 and its functionalized analogues UiO-66-Me, UiO-66-NO2, UiO-66-Me2 in the temperature range 433–573 K. In our study, we determined and analyzed the adsorption enthalpy, Henry constants, and entropic factors. Preferential adsorption of bulky molecules is observed with specific adsorbate and cage size effects, yielding very specific, preferential adsorption. Remarkably high adsorption selectivity factors (up to 14) for cyclo- compared to n-alkanes were found. The presence of additional groups (methyl, nitro) on the linkers in the framework influences adsorption properties significantly, mainly by reducing the effective pore size. Whereas increased selectivity is observed for UiO-66-Me, this effect decreases again upon addition of a second methyl group, UiO-66-M.
Attitude of Nursing Students towards Internet Plus Nursing Service

Background: In 2019, China completed the pilot project “Internet Plus Nursing Service. ” The study aimed to investigate the attitude, willingness, and motivation of third-year undergraduate nursing students toward “Internet Plus Nursing Service,” providing a reference for the development of “Internet Plus Nursing Service” and related nursing education. Methods: This cross-sectional study comprised 508 third-year undergraduate nursing students from a public University of Traditional Chinese Medicine, using a self-designed survey.Results: Of these 508 nursing students, 314 (61.81%) expressed support for the implementation of “Internet Plus Nursing Service,” 150 (29.52%) remained neutral and 44 (8.66%) expressed disapproval. In regards to career choice, 279 (54.92%) were willing to choose “Internet Plus Nursing Service” as their future career choice, 51 (10.04%) were unwilling, and 178 (35.04%) were unsure. The top three motivations to choose “Internet Plus Nursing Service” as their future career choice were added income, high autonomy and flexibility, and good job prospects. On the contrary, the top three motivation not to choose were safety concern, lack of time and energy, unwilling elderly care. gender, whether an only child or not, home location, and degree of knowledge and skills required for elderly care were not significantly associated with the willingness of nursing students to participate in “Internet Plus Nursing Service” (P > 0.05). Experience of community activities or a part-time job, elderly care experience, choice of nursing profession, satisfaction with nursing profession, willingness to engage in nursing work after graduation, and willingness to engage in elder care work were significantly associated with the willingness of nursing students to participate in “Internet Plus Nursing Service” (P < 0.05). Conclusion: Students had a positive attitude towards “Internet Plus Nursing Service” and were willing to choose “Internet Plus Nursing Service” as their future career choice. However, they lacked the willingness to engage in elder care after graduation. School education should strengthen the nursing education of elder care, develop a diversified nursing service model and professional training programs that meet social demands and professional needs, as well as address the opportunities and challenges of the Internet era.
COVID-19 – Challenges ahead of vaccination in immunocompromised patients

A novel strain of coronavirus — SARS-CoV-2 — was first detected in December 2019 in Wuhan, a city in China’s Hubei province, after an outbreak of pneumonia- like symptoms. The virus has now spread to over 200 countries and territories across the globe and was characterized as a pandemic by the World Health Organization (WHO) on 11 March 2020. To date, there is no proven effective treatment for the COVID-19 with ongoing trials on anti-viral and immunosuppressive therapies. Due to the highly contagious nature of COVID-19, the most promising way to contain the infection is by the development of a vaccine. Scientists all over the world are working tirelessly to develop a vaccine with several trials already undergoing and reaching phase 2. If and once a safe and effective vaccine is available, essential evidence-based considerations will be needed for the high-risk immunocompromised population. In this short summary, we are interpreting the current literature pertaining to vaccinations in patients on immunosuppressive medications and suggest how to implement management strategies in these patients once a vaccine is available for COVID-19.
Sleep Apnea and Diabetes Predict Progression of Cardiac Diastolic Dysfunction in Pre-heart Failure Patients: a Prospective Cohort HSCAA Study

[Background] Sleep apnea, a common co-morbid condition of diabetes, has been shown to be associated with established heart failure. However, its role in association of the presence of diabetes in the progression of cardiac diastolic function in pre-heart failure phase is not known. This prospective study is to longitudinally examine the predictive value of sleep apnea and diabetes on progression of left ventricular (LV) diastolic dysfunction in patients without heart disease. [Methods] Among 976 patients registered in HSCAA prospective cohort study, 517 without heart disease (175 type 2 diabetes, 342 non-diabetes) were followed with repeated echocardiography in every 1-3 years for a mean 34.7 months. LV diastolic dysfunction was determined by transmitral early inflow velocity/early diastolic tissue velocity (E/e´) >14. Annual change in E/e’ was calculated by using the slope of the linear regression line calculated from at least 3 echocardiographic measurements. Sleep apnea was determined by an apnomonitor device in conjunction with percutaneous oxygen saturation, and apnea hypopnea index (AHI) was calculated. [Results] Kaplan-Meier analyses revealed that subjects with diabetes or sleep apnea had a significantly (p<0.01) greater risk for LV diastolic dysfunction, with hazards ratio of 2.21 (1.41-3.47) and 2.23 (1.40-3.55), respectively. Subjects with sleep apnea exhibited significantly higher risk for LV diastolic dysfunction in non-diabetic subjects (p<0.01), while showed tendency of higher risk in diabetic subjects (p=0.10). The annual change of E/e’ was significantly and independently associated with both diabetes (β=0.278, p<0.01) and AHI (β=0.138, p<0.01). Finally, ROC analyses revealed that addition of AHI and diabetes to classical risk factors best predicted individuals with fast progression of diastolic dysfunction (annual change of E/e’ >1.0) with an AUC of 0.81. [Conclusions] In patients without heart disease, sleep apnea is an important predictor for progression of LV diastolic dysfunction. Its association is partly confounded, but still independent of the presence of diabetes.
A Noise-Reduction Method With Coherence Enhancement for Binaural Hearing Aids

—In this work, a variation of the multichannel Wiener filter (MWF) for noise reduction in binaural hearing aid applications is proposed. This method provides improved spatial preservation for acoustic scenarios comprised of one single-point target (speech) and one single-point interfering (noise) acoustic sources. It employs a regularization penalty term based on the inverse of the magnitude of the interaural coherence (IC), with the aim of enhancing the original azimuth perception of the interferent source. The proposed penalty term artificially intensifies the IC of the residual interference, increasing similarity in both ears. This is of special value for low-coherent reverberant acoustic signals, in which the reliability of the received binaural cues associated to the single-point interferent source was degraded by multiple acoustic reflections. Simulation results obtained with objective criteria show that, in addition of providing improved spatial preservation for the interferent source, the proposed approach may also provide higher noise reduction performance as compared to the conventional MWF approach. Further, it also yields an extended range for the target and interference spatial-preservation trade-off, as compared to a previously developed competing method. experiments with normal hearing volunteers corroborate theoretical and simulation findings.
EKSPERIMENTASI PENDEKATAN SAINTIFIK TERHADAP KEMAMPUAN KOMUNIKASI MATEMATIS DITINJAU DARI SELF-EFFICACY SISWA

The purpose of this study is to describe the mathematical communication skills that are taught with a scientific approach better than conventional learning of class IX students of SMP Negeri 43 Merangin 2019/2020 academic year. This research uses a quantitative approach with an experimental method. The sampling technique uses simple random sampling. Samples are grouped by self-efficacy high, medium and low. Data collection techniques using test and non-test. Analysis technique uses t-test and two-way ANOVA. The test results state that: mathematical communication skills both overall and with self-efficacy high, moderate and low taught with a scientific approach are better than conventional learning, and there is an interaction between scientific approaches and conventional learning in terms of self-efficacy in influencing mathematical communication skills.
O espaço público e suas territorialidades: a experiência das mulheres nos estádios de futebol

Supported by patriarchal principles, beliefs and customs have historically produced gender inequality. Through correspondence between gendered behaviors, originated in the cities and reverberated in collective buildings, it is intended to build a reflection on the female experience in football stadiums and to understand the possibilities of use and affection of women in these so-called male buildings, as well as in the public space related to them, through bibliographic based methodology. It is maintained that, even with the increase of the female public in the stadiums, there are obstacles and prejudices that, associated to the existing difficulties in the public space, limit uses and trigger conflicting experiences. This article proposes an evaluation of the formation of stadiums and their sociability, through the questioning of the instituted regulations and the speeches and negotiations related to their ethos, as a contribution to the advancement of critical reflection about gender relations in contemporary cities.
Antimycobacterial, antiplasmodial studies and cytotoxicity of oleanolic acid and its derivative from Syzygium aromaticum Linn (Myrtaceae)

Malaria and tuberculosis are among the most common death causes and threats to human life globally. In a quest to find new antimalarial and anti-mycobacterial drugs, oleanolic acid (OA) was isolated from the flower buds of Syzygium aromaticum Linn (Myrtaceae). The derivative, 3-O-Acetyl-Oleanolic acid (OAA), was synthesized from the isolated product and the biological activities of the two compounds were compared. The antiplasmodial and antimycobacterial activity of oleanolic acid and its derivative were investigated against Plasmodium falciparum (Chloroquine Sensitive Strain) NF54 and Mycobacterium tuberculosis H37Rv. OAA exhibited IC50 of 4.3 μg/ml against P. falciparum, compared with an IC50 of 27.4 μg/ml for OA, while against M. tuberculosis OAA showed 0.1 μg/ml, compared with an IC50 of 0.042 μg/ml for OA. In the cytotoxicity studies, using the MTT assay, both compounds exhibited LC50 of > 300 μg/ml against both human embryonic kidney (HEK293) and hepatocellular carcinoma cell lines (HepG2), suggesting that the compounds are not cytotoxic at low to moderate concentrations against the tested cell lines. In conclusion, the derivative OAA improved the antiplasmodial activity but no improvement was shown for antimycobacterial activity, in comparison with the starting material OA. Thus, more derivatives could be designed, using OA as starting material, to obtain future antiplasmodial compounds.
An LLC Converter With Multiple Operation Modes for Wide Voltage Gain Range Application

Although LLC converters are attractive in industrial applications due to its advantages of soft switching, high efficiency, and simple control, in wide voltage gain range applications, large switching frequency operating range is required, which may cause the loss of soft switching operation and existence of control instability issue. In this article, a novel LLC converter with two LLC resonant tanks is proposed. The proposed converter has three operation modes, namely, dual full-bridge operation mode, full-bridge operation mode, and half-bridge operation mode, which can cover the high voltage gain range, medium voltage gain range, and low voltage gain range operations, respectively. The operational principles of the proposed converter are presented, and brief design considerations are discussed. A 250 W experimental prototype with six times input voltage range (50–300 V) was built to validate the theoretical analysis of the proposed converter. Comparisons among different LLC topologies for wide voltage gain range applications are made.
Identifying Periampullary Regions in MRI Images Using Deep Learning

Background Development and validation of a deep learning method to automatically segment the peri-ampullary (PA) region in magnetic resonance imaging (MRI) images. Methods A group of patients with or without periampullary carcinoma (PAC) was included. The PA regions were manually annotated in MRI images by experts. Patients were randomly divided into one training set, one validation set, and one test set. Deep learning methods were developed to automatically segment the PA region in MRI images. The segmentation performance of the methods was compared in the validation set. The model with the highest intersection over union (IoU) was evaluated in the test set. Results The deep learning algorithm achieved optimal accuracies in the segmentation of the PA regions in both T1 and T2 MRI images. The value of the IoU was 0.68, 0.68, and 0.64 for T1, T2, and combination of T1 and T2 images, respectively. Conclusions Deep learning algorithm is promising with accuracies of concordance with manual human assessment in segmentation of the PA region in MRI images. This automated non-invasive method helps clinicians to identify and locate the PA region using preoperative MRI scanning.
Hormonal Changes Across the Life Cycle of Women and its Effects on the Periodontium

In recent years, it has been realized that women’s oral health may differ from that of men in many areas.It is rightly said that the health of a woman’s body and oral cavity are bidirectional, hence women needexceptional dental health facilities and attention. The role that different endocrine hormones imbalancesduring puberty, 1st to 3rd trimester of pregnancy, menopause, oral contraceptive use, and females reproductivecycle details has the main role in various sex data in orofacial health status is supported by different medicalclinical trials. The oral conditions commonly observed during these phases of the lifecycle of femalesinclude inflamed gingiva, the formation of granulomatous tissue in the body, disease of periodontium,, andgrade 1,2,3 mobility of tooth. The closest bonding between status and worst dental health condition in thefemale will need excellent care in investigation plan that assimilates and controls for the diverse array oflurking varying, such as dental diseases (gingivitis, periodontitis and missing tooth), the whole history offemale’s reproductive physiology, and benefaction communal and financial variables. Dental practitionersneed to actively counsel female patients about general and oral health strategies so that they can maintaintheir oral health and maximize their quality of life. The effect of hormonal changes during the life cycle of afemale affects the prevalence and intensity of the oral disease. This understanding is helpful for a clinicianin rendering oral health care to these patients.
Social entrepreneurial intention: A systematic literature review and outlook

social entrepreneurial intention, social entrepreneurship, systematic literature review Since 2017, social entrepreneurial intentions are a rapidly growing field of research. The research to explain the formation of intent to establish social enterprises be approached from many aspects, as well as based on different theoretical backgrounds. However, a large part of this study lacked systematization and classifications, and there seems to be a tendency to start anew with every study. Therefore, there should be an overview of current knowledge in this field. In this sense, this article does a literature review of social entrepreneurial intentions. A total of 51/138 articles related to social entrepreneurial intentions searched from the Scopus database, published between 2006 and 2020, were analyzed. The purpose and contribution of this paper are to provide a clearer picture of the research approaches in social startup intent research. Several research gaps are identified in each of these approaches, with implications for researchers interested in filling these theoretical gaps.
Toxic responses in human lung epithelial cells (BEAS-2B) exposed to particulate matter exhaust emissions from gasoline and biogasoline

Motor vehicle emissions substantially contribute to air pollution worldwide and cause serious health problems. While the deleterious effects of diesel exhaust particulate matter (PM) have been widely studied, much less attention is paid to toxicity of PM emitted by gasoline engines although they also produce considerable amount of PM. The primary objective of this research was to assess toxic potencies of exhaust PM released by conventional gasoline engine fueled with neat gasoline (E0) or gasoline-ethanol blend (15% ethanol, v/v, E15). Despite a similar particle mass (μg PM/kg fuel) produced by both fuels, PM emitted by E15 contained higher amount of harmful polycyclic aromatic hydrocarbons (PAH) as suggested by chemical analysis. To examine the toxicity of organic PM constituents, human lung BEAS-2B cells were exposed for 4h and 24h to a subtoxic dose of E0 and E15 PM organic extracts. We used genome scale transcriptomic analysis to characterize the toxic response and to identify modulated biological process and pathways. Whereas 4h exposure to both PM extracts resulted in modulation of similar genes and pathways related to lipid and steroid metabolism, activation of PPARα, oxidative stress and immune response, 24h exposure was more specific for each extract; although both induced expression of PAH-metabolic enzymes, modulated metabolism of lipids or activated PPARα, E15 additionally deregulated variety of other pathways. Overall, the PM mass produced by both fuels was similar, however, higher PAH content in E15 PM organic extract may have contributed to more extensive toxic response particularly after 24h exposure in BEAS-2B cells.
China’s Tourism Diplomacy in the Context of BRI

In 2015, Chinese Ministry of Culture and Tourism formally put forward the official concept of tourism diplomacy, defining tourism as a “comprehensive strength with both soft and hard power”. Since the launching of the China-Russia Tourism Year, the tourism year mechanism has gradually formed, and the term “tourism diplomacy” has frequently appeared in government reports and officials’ speeches. Based on the authorization, support and guarantee of the national government, tourism diplomacy generates tourism flows through the attraction of tourism to establish economic, trade and humanistic connections with the world, shapes a positive national image, serves the country’s diplomacy, and enriches the connotation of major-country diplomacy with Chinese characteristics.