Miracle-dz/UniFAR-FTUs huggingface dataset:
Improvement in binding affinity of Ginkgolide B in comparison to Levodopa : A molecular docking Study

Parkinson’s disease involves the malfunction and de ath of vital nerve cells in the brain called neuron which produce dopamine, a chemical that sends message to the part of the brain that controls movement and coordinati on. As Parkinson’s disease progresses, the amount of dopam ine produced in the brain decreases, leaving a pers on unable to control movement normally. The test drug Ginkgol ide B and standard drug Levodopa have targeted the protein D2 receptor (PDB ID: 2YOU) and protein D 3 receptor (PDB ID: 3PBL) respectively. Both the tes t and standard drug were drawn using Chemsketch draw software and structures were optimized using Arguslab software. Then they were docked with the Dopamine D 2 protein (PDB ID: 2YOU) and Dopamine D 3 protein (PDB ID: 3PBL) using HEX software. The test drug showed improvement in b inding affinity and other properties in comparison to standard drug.
1 Bioactive Coating on Titanium Dental Implants for 2 Improved Anticorrosion Protection : A Combined 3 Experimental and Theoretical Study 4

In recent years extensive studies have been continuously undertaken on the design of 18 bioactive and biomimetic dental implant surfaces due to the need for improvement of the 19 implant-bone interface properties. In this paper, the titanium dental implant surface was modified 20 by bioactive vitamin D3 molecules by self-assembly process in order to form an improved 21 anticorrosion coating. Surface characterization of the modified implant was performed by field 22 emission scanning electron microscopy (FE-SEM), attenuated total reflection-Fourier transform 23 infrared spectroscopy (ATR-FTIR), and contact angle measurements (CA). Implant’s 24 electrochemical stability during exposure to an artificial saliva solution was monitored in situ by 25 electrochemical impedance spectroscopy (EIS). Experimental results obtained were corroborated 26 by means of quantum chemical calculations at the density functional theory level (DFT). The 27 formation mechanism of the coating onto the titanium implant surface was proposed. During a 28 prolonged immersion period, the bioactive coating effectively prevented the underlying titanium 29 from corrosive attack (polarization resistance in order of 107 Ω cm2) with ~95% protection 30 effectiveness. 31
RELATIONS BETWEEN ABS-NORMAL NLPS AND MPECS UNDER WEAK CONSTRAINT QUALIFICATIONS

This work continues an ongoing effort of comparing non-smooth optimization problems in abs-normal form to MPECs. We continue our study of general NLPs with equality and inequality constraints in abs-normal form, and their relation to equivalent MPEC reformulations. We introduce Abadie’s and Guignard’s kink qualification and prove relations to ACQ and GCQ for MPEC reformulations. Due to non-uniqueness of a specific slack reformulation, suggested in [8], the relations are non-trivial. It turns out that constraint qualifications of Abadie type are preserved. As we cannot show this for Guignard type we introduce branch formulations for abs-normal NLPs and MPECs. Then, equivalence of Abadie’s and Guginard’s constraint qualifications for all branch problems hold. Finally, we consider M-stationarity and B-stationarity concepts for abs-normal NLPs and prove corresponding first order optimality conditions.
Data processing handover in the multi-access edge computing setting

The multi-access edge computing (MEC) technology is a key pillar of the 5th generation (5G) telecommunication network. Among other benefits, it will allow for ultra-low latency communications by bringing computations closer to the user equipment (UE). However, when the UE changes its position, the problem of keeping computations close to it arises. In this work I study this problem related to handover, taking the Megasense project as a real life use case. I propose, implement and analyze a solution that aims at solving the aforementioned problem within a prototype system developed by Nokia Bell Labs.
The Structure of Aerial Displays in Three Species of Calidridinae (Scolopacidae)

ABsT•-•CT. --Sandpipers in the subfamily Calidridinae (Scolopacidae) breed in the Arctic and Subarctic. In all species, unpaired males engage in distinctive aerial displays. Such displays are described for three species: Dunlin (Calidris alpina L.), Semipalmated Sandpiper (Calidris pusilla L.), and Stilt Sandpiper (Calidris himantopus Bonaparte). In each of the species, displays last several minutes, during which simple monotonous calls are emitted; more complex calls (including "Song") also occur. C. himantopus has a unique flight mode, which is considered as apomorphous (derived) within the subfamily. C. alpina is apomorphous for the buzziness of the main vocalization emitted in aerial display and C. pusilla for loss of the same vocalization and elaboration of another. The ancestral/derived status and systematic value of these and other display components are discussed, with reference to information available for other calidridine species. Received 2 August 1982, accepted 10 December 1982.
CHANGES OF MAGNETIC MINOR HYSTERESIS LOOPS DURING CREEP IN CR-MOV FERRITIC STEEL

We analyzed magnetic minor hysteresis loops of 1Cr-0,5Mo-0.25V ferritic steel subjected to creep at 923 K under tensile stress of 25 MPa. The minor-loop coefficients, which are obtained from the power-law scaling rules and indicators of internal stress, sharply decrease at the primary creep, become almost constant at the secondary creep, and then slowly decrease at the ternary creep. This behavior is similar to that of Vickers hardness and both the properties show a linear relation. The good relationship between the coefficients, creep strain and hardness as well as a low measurement field required for the coefficients indicate that magnetic method using minor hysteresis loops can be a possible technique for nondestructive evaluation of ferritic steels during creep.
String Searching Algorithm : A Predictive Approach

In today’s time computer systems produce large volumes of data. In order to extract valuable information from this data various new techniques are being developed and used. This has led to the increase in the importance of text processing and consequently string searching.In this paper a new string searching algorithm is presented that uses intelligent predictions based on text features to search for a string in a text. The proposed algorithm has been developed after analyzing the existing algorithms such as KMP, Boyer-Moore and Horspool. One unique feature of this algorithm is that unlike the existing algorithms, it does not require preprocessing the pattern to be searched. As a result it does not incur the overhead required in pre-processing the pattern. The algorithm searches through a given text to find the first occurrence of a pattern. It does not involve complex computations and uses simple rules during a match or mismatch of a pattern character. Based on the variety of applications coming up in areas of data and information mining, sentiment analysis, DNA pattern matching etc, this simple, elegant and intelligent algorithm will find its application. General Terms String searching
DISCOUNTING OF DELAYED REINFORCERS : MEASUREMENT BY QUESTIONNAIRES VERSUS OPERANT CHOICE PROCEDURES

The ability of a reinforcer to maintain behavior decreases as a hyperbolic function of its delay. This discounted value can help explain impulsivity defined as the choice of an immediate, small reinforcer over a delayed, large reinforcer. Human operant studies using consumable reinforcers such as videos have found impulsivity with delays under 1 min . However, measures of discounting rates using questionnaires that dElscribe hypothetical amounts of monetary reinforcers and delays of days, months, or years have found discounting rates that are much too low to explain impulsive choice in operant procedures. A comparison of discounting rates across questionnaire and operant studies indicates that questionnaires produce slower discounting because of the absence of both reinforcement and consumption processes. Combining reinforcement with questions about future reinforcers could facilitate the integration of questionnaire research into a behavioral framework.
Nitrogen Assimilation by Plants P 1 iysiological , Biochemical and Molecular Aspects

The grains and seeds of plants are meant for propagation and dispersion but are also harvested and consumed by human beings. The protein content of grains and seeds varies from 10% (in cereals) to 40% (in some leguminous and oleaginous plants). In quantitative terms, the contribution of grains and seeds to human and animal nutrition (200 million tons per year for cereal proteins alone) economically constitutes a significant and major protein source (Shewry et al., 1995). In angiosperms, double fertilisation takes place in the embryo sac inside the ovule. One of the male nuclei fuses with the principal female nucleus, giving rise to a diploid embryo. The other male nucleus fuses with the two polar nuclei to form a triploid nucleus. This triploid nucleus gives rise to the endosperm, the main tissue of monocotyledons (especially in cereals) which represents the primary nourishing tissue of the grain; reserves are stored in it. In dicotyledonous seeds (especially legumes), the cotyledons also represent the principal reserve source. These reserves of the grains and seeds mainly consist of starch, proteins and lipids and are used for nourishing the seedling after germination.
Award Number: DAMD17-96-1-6198 TITLE: The Role of PTHrP in Mammary Gland Development and Tumorigenesis

s/Presentations 1. Wysolmerski, JJ, Dunbar, M, Karaplis, AC, Broadus, AE, Philbrick, WM. PTHrP is necessary for mammary epithelial development. Chosen for an oral presentation at 1996 meeting of the American Society of Bone and Mineral Research. 2. Dunbar, ME, Philbrick, WM, Broadus, AE, Wysolmerski, JJ. PTHrP modulates the branching morphogenesis of mammary epithelial cells in vitro. Poster presentation at 1996 meeting of the American Society of Bone and Mineral Research. 3. Wysolmerski JJ, Lanske B, Kronenberg HM, Broadus AE, Philbrick WM. Disruption of the PTH/PTHrP receptor gene leads to a failure of mammary gland development. Chosen for an oral presentation at 1997 Endocrine Society Meetings. 4. "The role of PTHrP in mammary gland development" Gordon Research Conference on Mammary Gland Biology, 6/97. Plymouth State College, Plymouth, New Hampshire 5. Dunbar M, McCaughern-Carucci J, Zhang JP, Wysolmerski JJ. The analysis of PTHrP and PTH/PTHrP receptor expression in the murine mammary gland. Poster presentation at 1997 Gordon Research Conference on mammary gland biology. 6. "PTHrP is necessary for mammary epithelial development" Conference on Breast Development, Physiology and Cancer, 6/97, National Institutes of Health, Bethesda, Maryland 7. Wysolmerski JJ, Dunbar ME, Karaplis A, Lanske B, Kronenberg H, Broadus AE, Philbrick WM. Parathyroid Hormone-related Protein is Necessary for Mammry Epithelial Development. Selected for Oral Platform Presentation at 1997 Department of Defense Breast Cancer Research Program Meeting. 8. Dunbar M, Dann P, Robinson T, Wysolmerski J. PTHrP Signaling is Necessary for Sexual Dimorphism During Fetal Mammary Development. Selected for oral presentation, 1998 Joint Meeting of the American Society for Bone and Mineral Research and the International Bone and Mineral Society. 9. Dunbar ME, Young P, Zhang JP, McCaughern-Carucci J, Lanske B, Orloff J, Karaplis A, Cunha G, Wysolmerski JJ. Stromal cells are critical targets in the regulation of mammary ductal morphogenesis by parathyroid hormonerelated protein (PTHrP). Poster presentation at 1998 Joint Meeting of the American Society for Bone and Mineral Research and the International Bone and Mineral Society.
WP / 19 / 68 Financial Deepening , Terms of Trade Shocks , and Growth Volatility in Low-Income Countries

This paper contributes to the literature by looking at the possible relevance of the structure of the financial system—whether financial intermediation is performed through banks or markets—for macroeconomic volatility, against the backdrop of increased policy attention on strengthening growth resilience. With low-income countries (LICs) being the most vulnerable to large and frequent terms of trade shocks, the paper focuses on a sample of 38 LICs over the period 1978-2012 and finds that banking sector development acts as a shock-absorber in poor countries, dampening the transmission of terms of trade shocks to growth volatility. Expanding the sample to 121 developing countries confirms this result, although this role of shock-absorber fades away as economies grow richer. Stock market development, by contrast, appears neither to be a shock-absorber nor a shock-amplifier for most economies. These findings are consistent across a range of econometric estimators, including fixed effect, system GMM and local projection estimates. JEL Classification Numbers: F40, G20, O10
Cultural and National Factors in Nuclear Safety

This workshop is based on a very important, perhaps life saving, curiosity. How do larger cultural and national factors influence nuclear power plant safety? As the organizers highlight the importance: “In the light of the Fukushima Daiichi nuclear accident some observers have pointed out that certain unique national factors impacted, both positively and negatively, on the safety culture that prevails in Japan’s nuclear industry. This is, of course, not only true of Japan; all nations have their strengths and weaknesses. The commonly used approach when assessing and working with safety culture improvements, however, does not encompass national factors. A global vision and approach towards strengthening safety culture are needed. ” “. every Member State needs to ask itself what factors in its national culture context can facilitate or hinder the development of a strong safety culture. ”
A Path Signature Approach for Speech Emotion Recognition

Automatic speech emotion recognition (SER) remains a difficult task within human-computer interaction, despite increasing interest in the research community. One key challenge is how to effectively integrate short-term characterisation of speech segments with long-term information such as temporal variations. Motivated by the numerical approximation theory of stochastic differential equations (SDEs), we propose the novel use of path signatures. The latter provide a pathwise definition to solve SDEs, for the integration of short speech frames. Furthermore we propose a hierarchical tree structure of path signatures, to capture both global and local information. A simple tree-based convolutional neural network (TBCNN) is used for learning the structural information stemming from dyadic path-tree signatures. Our experimental results on a widely used benchmark dataset demonstrate comparable performance to complex neural network based systems.
Reducing Hospital Readmissions in New York State: A Simulation Analysis of Alternative Payment Incentives. New York, NY: New York State Health Foundation

This report estimates the effects of reimbursement strategies and provider-level interventions to reduce hospital readmissions. Several quality-improvement interventions have proved effective in reducing readmission rates, but relatively few hospitals have adopted these programs, in large part due to lack of financial incentives. The report examines whether new pay-for-performance and episode-based payment approaches provide incentives for these programs. The report also explores an alternative direct payment model that could be more effective than current strategies.
Les coliques du nourrisson : les interventions alimentaires ont-elles un rôle à jouer?

Les coliques du nourrisson sont un syndrome comportemental de la premiere enfance qui s’associent a l’irritabilite et aux pleurs. Ellessont spontanement resolutives, mais peuvent entrainer d’importantes dissensions parentales. Meme si on n’en connait pas l’etiologie, plusieurs chercheurs ont examine l’effet de l’alimentation sur les coliques du nourrisson. Pour la majorite des nourrissons, les interventions alimentaires semblent ne rien changer aux coliques. Cependant, une minorite d’entre eux peuvent presenter des symptomes de coliques secondaires a une allergie aux proteines du lait de vache. Dans de tels cas, un regime hypoallergene pour la mere si le nourrisson est allaite et une preparation fortement hydrolysee si le nourrisson est nourri au biberon peuvent resoudre les coliques. Le role des preparations a base de soja ou du traitement par lactase n’est pas demontre pour la prise en charge des coliques du nourrisson, et ces interventions ne sont pas recommandees. Pour l’instant, les donnees sont insuffisantes pour formuler une recommandation sur l’effet des probiotiques sur les coliques du nourrisson. Dans tous les cas de coliques du nourrisson, il est important de s’assurer d’un soutien parental suffisant. Selon les criteres de Rome III pour les troubles gastro-intestinaux fonctionnels, les coliques du nourrisson incluent tous les elements suivants chez les nourrissons de moins de quatre mois (1) : paroxysmes d’irritabilite, d’agitation ou de pleurs qui commencent et s’arretent sans raison evidente; episodes d’au moins trois heures par jour, au moins trois jours par semaine, pendant au moins une semaine; absence de retard staturoponderal. On ne connait pas les etiologies des coliques du nourrisson, mais les professionnels de la sante tentent souvent des interventions alimentaires. Le present article met a jour le precedent point de pratique de la Societe canadienne de pediatrie sur le role des modifications alimentaires pour traiter les coliques du nourrisson.
The Use of Non-Nutritive Sweeteners in Establishing and Maintaining A Healthy Weight

The Use of Non-Nutritive Sweeteners in Establishing and Maintaining a Healthy Weight Derrick Pickering College of Nursing, BYU Master of Science in Nursing Obesity is an epidemic and continues to rise. The associated increased risk of mortality and co-morbid conditions is well documented. The use non-nutritive sweeteners (NNS) is a strategy being used to manage weight by reducing calorie intake. Research is inconclusive regarding the efficacy of NNS in weight management due to their inappropriate use and also the potential they may increase appetite. To most effectively manage weight, a comprehensive individualized plan must be devise of which proper use NNS may be a part.
Seroprevalence of toxoplasmosis in aborted women in Babylon Province, Iraq

Background: Toxoplasmosis is considered as one of the most prevalent human parasitic infections that can be transmitted from mother to the fetus. The onset of toxoplasmosis during pregnancy has clinical complications, including spontaneous abortion, preterm labor, stillbirth, and fetal abnormalities. Objective: The aim of this study was to investigate the seroprevalence of toxoplasmosis infection in aborted women. Materials and Methods: Seventy-five sera samples were collected from the women admitted in the obstetrics and gynecology ward with abortion. The blood samples were processed appropriately and tested for Toxoplasma gondii IgM and IgG using enzyme-linked immunosorbent assay (ELISA) technique, in addition to latex agglutination test (LAT) as a screening test. Results: Seropositivity of aborted women to T. gondii was 42.6% when used LAT while 4% and 22.6% when detection of T. gondii IgM and IgG respecyively ELISA.the highest percentage of infection was found to be 18.6% in the age group of 21–25 years, in patients inhibited in rural area. Also seropositive in women with double frequent of abortion. Conclusion: ELISA test was the best method to investigate toxoplasmosis in aborted women, especially with recurrent spontaneous abortion.
Genetic and nongenetic factors explaining metabolically healthy and unhealthy phenotypes in participants with excessive adiposity: relevance for personalized nutrition

Background: Different genetic and environmental factors can explain the heterogeneity of obesity-induced metabolic alterations between individuals. In this study, we aimed to screen factors that predict metabolically healthy (MHP) and unhealthy (MUP) phenotypes using genetic and lifestyle data in overweight/obese participants. Methods: In this cross-sectional study we enrolled 298 overweight/obese Spanish adults. The Adult Treatment Panel III criteria for metabolic syndrome were used to categorize MHP (at most, one trait) and MUP (more than one feature). Blood lipid and inflammatory profiles were measured by standardized methods. Body composition was determined by dual-energy X-ray absorptiometry. A total of 95 obesity-predisposing single-nucleotide polymorphisms (SNPs) were genotyped by a predesigned next-generation sequencing system. SNPs associated with a MUP were used to compute a weighted genetic-risk score (wGRS). Information concerning lifestyle (dietary intake and physical activity level) was collected using validated questionnaires. Results: The prevalence of MHP and MUP was 44.3% and 55.7%, respectively, in this sample. Overall, 12 obesity-related genetic variants were associated with the MUP. Multiple logistic regression analyses revealed that wGRS (OR = 4.133, p < 0.001), total dietary fat [odds ratio (OR) = 1.105, p = 0.002], age (OR = 1.064, p = 0.001), and BMI (OR = 1.408, p < 0.001) positively explained the MUP, whereas female sex (OR = 0.330, p = 0.009) produced a protective effect. The area under the receiver operating characteristic curve using the multivariable model was high (0.8820). Interestingly, the wGRS was the greatest contributor to the MUP (squared partial correlation = 0.3816, p < 0.001). Conclusions: The genetic background is an important factor explaining MHP and MUP related to obesity, in addition to lifestyle variables. This information could be useful to metabolically categorize individuals, as well as for the design/implementation of personalized nutrition interventions aimed at promoting metabolic health and nutritional wellbeing.
A Study of Stress, Coping, Social Support, and Mental Health in Police Personnel of Uttar Pradesh

Background: Presence of enormous stress gives birth to a higher prevalence of mental health difficulties. Globally, the job of police personnel is full of stress. Coping strategies and social support have a crucial role to play in the management of stress and mental health. Objective: The objective of this study was to study stress, social support, coping, and mental health in the police personnel of Uttar Pradesh. Methodology: The sample comprised 300 male police personnel including 100 constables, 100 inspectors, and 100 officers being incidentally selected from six districts of Uttar Pradesh viz. Lucknow, Varanasi, Meerut, Raibareilly, Ghazipur, and Noida. The mean age of the sample was 40 years and average experience of 15 years of police service. They were assessed by using Occupational Stress Questionnaire (OSQ, Gmelch and Chan, 1994), Brief COPE Scale (Carver, 1997), Social Support Scale (Cohen et al. 1985), and Mental Health Inventory (Jagdish and Srivastava, 1983). The results obtained were analyzed statistically, the mean score was calculated, and the independent t-test was applied. Results: Among the police personnel, inspectors scored highest mean occupational stress score (39.89 ± 13.17) with the lowest mean score of active coping (17.40 ± 7.37), adaptive coping (23.81 ± 8.59), and the highest mean score in maladaptive coping (21.43 ± 7.89). Mental health of inspectors was most adversely affected with highest mean score (97.81 ± 24.49). Conclusion: The study concludes that the amount of stress experienced by all echelons of police is extremely high and almost of similar level except for inspectors showing highest among the three groups, thus emphasizing the use of healthy coping mechanisms and modification in work environment promoting health and well-being.