Miracle-dz/UniFAR-FTUs huggingface dataset:
A Low-Rank Matrix Approximation Approach to Multiway Matching with Applications in Multi-Sensory Data Association

Consider the case of multiple visual sensors perceiving the same scene from different viewpoints. In order to achieve consistent visual perception, the problem of data association, in this case establishing correspondences between observed features, must be first solved. In this work, we consider multiway matching which is a specific instance of multi-sensory data association. Multiway matching refers to the problem of establishing correspondences among a set of images from noisy pairwise correspondences, typically by exploiting cycle- consistency. We propose a novel optimization-based formulation of multiway matching problem as a nonconvex low-rank matrix approximation problem. We propose two novel algorithms for numerically solving the problem at hand. The first one is an algorithm based on the Alternating Direction Method of Multipliers (ADMM). The second one is a Riemannian trust- region method on the multinomial manifold, the manifold of strictly positive stochastic matrices, equipped with the Fisher information metric. Experimental results demonstrate that the proposed methods have the state of the art performance in multiway matching while reducing the computational complexity compared to the state of the art.
Crystallographic Studies of Invasin, a Bacterial Adhesion Molecule from Yersinia pseudotuberculosis

Bacterial pathogens, such as Yersinia pseudotuberculosis, must bind and enter normally non-phagocytic cells to establish infection. The protein responsible for mediating uptake of the bacterium is a 986-residue outer membrane protein called invasin. Invasin binds to several members of the beta 1 integrin family, presumably activating a reorganization of the host cytoskeleton to form pseudopods that envelop the bacterium. Integrin binding has been localized to the extracellular region of invasin (Inv497) comprised by the COOH-terminal 497 residues. In order to gain insight into host cell entry by Yersinia pseudotuberculosis, we solved the 2.3 Scrystal structure of Inv497. The structure reveals five domains that form a 180 Srod with structural similarities to tandem fibronectin-III domains. The integrin-binding surfaces of invasin and fibronectin include similarly located key residues, but in the context of different folds and surface shapes. The structures of invasin and fibronectin provide an example of convergent evolution, in which invasin presents an optimized surface for integrin binding compared with host substrates. We have also initiated structural analyses of the NH2-terminal ~500 residues of invasin, which are required for outer membrane localization and for presentation of the integrin-binding region of invasin. We expressed this region of invasin as inclusion bodies in E. coli, and refolded the protein in the presence of detergents. We have also obtained microcrystals of this membrane protein. Circular dichroism studies indicate that this region of invasin is composed of mainly beta-structure. As the transmembrane regions of outer membrane proteins of known structure are beta-barrels, this region of invasin is also presumed to fold into such a structure. Proteolysis experiments suggest that the NH2-terminal 70 amino acids of invasin may form a separate domain from the invasin transmembrane region, analogous to that found in another outer membrane protein, the sucrose-specific porin ScrY. Equilibrium sedimentation analytical ultracentrifugation studies indicate the protein is monomeric in solution. Black bilayer experiments suggest that this region of the protein does not contain a pore and thus plays the role of an outer membrane anchor for the presentation of the integrin-binding domain on the cell surface
DeepClassic: Music Generation with Neural Neural Networks

Art generation is an exciting research ﬁeld in the domain of AI. Music is a very structured, but extremely complex, form of language, but when thinking about composing, one would primarily think that it comes to human genius, creativity and emotions, and disrupting music codes has always been the aim of the successive method of composition through musical history. It is thus extremely interesting to be able to try out new models to see how innovative they can be for music composition tasks. In this paper, we are interested in ﬁnding if sequential Deep Learning Models can be as efﬁcient in music generation as they are in Natural Language Processing. We develop RNN, LSTM and LSTM with attention models, we manage to create short music scores that actually sounds like it could be created by a composer.
Metal nickel exposure increase the risk of congenital heart defects occurrence in offspring

Background: Previous studies have investigated heavy metal exposure could increase the occurrence of congenital heart defects (CHDs). However, there are limited data regarding the relationship between exposure to nickel and CHDs occurrence in offspring. The aim of this study was to analyze the association between nickel exposure in mothers and the risk of CHDs in offspring. Materials and methods: To explore the association of nickel exposure and occurrence of CHD, a case-control study with 490 controls and 399 cases with CHDs in China were developed. The concentrations of nickel in hair of pregnant woman and fetal placental tissue were measured and used a logistic regression analysis to explore the relationship between nickel exposure and risk of CHD. Results: The median concentrations of nickel were 0.629 ng/mg, P < . 05 (adjusted odds ratio [aOR], 1.326; 95% CI, 1.003–1.757) and 0.178 ng/mg, P < . 05 (aOR, 2.204; 95% CI, 0.783–6.206), in maternal hair and in fetal placental tissue in the CHD group, respectively. Significant differences in the level of nickel in hair were also found in the different CHD subtypes including septal defects (P < .05), conotruncal defects (P < .05), right ventricular outflow tract obstruction (P < .01), and left ventricular outflow tract obstruction (P < .05). Dramatically different nickel concentrations in fetal placenta tissue were found in cases with other heart defects (P < .05). Conclusions: The finding suggested that the occurrence of CHDs may be associated with nickel exposure.
BIO012815 1024..1039

The deregulation of cell polarity or cytoskeletal regulators is a common occurrence in human epithelial cancers. Moreover, there is accumulating evidence in human epithelial cancer that BTB-ZF genes, such as Bcl6 and ZBTB7A, are oncogenic. From our previous studies in the vinegar fly, Drosophila melanogaster, we have identified a cooperative interaction between a mutation in the apico-basal cell polarity regulator Scribble (Scrib) and overexpression of the BTB-ZF protein Abrupt (Ab). Herein, we show that co-expression of ab with actin cytoskeletal regulators, RhoGEF2 or Src64B, in the developing eye-antennal epithelial tissue results in the formation of overgrown amorphous tumours, whereas ab andDRac1 co-expression leads to non-cell autonomous overgrowth. Together with ab, these genes affect the expression of differentiation genes, resulting in tumours locked in a progenitor cell fate. Finally, we show that the expression of two mammalian genes related to ab,Bcl6 andZBTB7A, which are oncogenes inmammalian epithelial cancers, significantly correlate with the upregulation of cytoskeletal genes or downregulation of apico-basal cell polarity neoplastic tumour suppressor genes in colorectal, lung and other human epithelial cancers. Altogether, this analysis has revealed that upregulation of cytoskeletal regulators cooperate with Abrupt in Drosophila epithelial tumorigenesis, and that high expression of human BTB-ZF genes, Bcl6 and ZBTB7A, shows significant correlations with cytoskeletal and cell polarity gene expression in specific epithelial tumour types. This highlights the need for further investigation of the cooperation between these genes in mammalian
Balloon-stent kissing technique versus jailed wire technique for interventional treatment of coronary bifurcation lesions

Abstract Side-branch occlusion is a serious complication of provisional one-stent strategies used to treat coronary bifurcation lesions. The aim of the study was to compare the short- and long-term clinical outcomes between the balloon-stent kissing technique (BSKT) and jailed wire technique (JWT) in patients with non-left coronary bifurcation lesions. This prospective, double-blinded, randomized controlled study enrolled 89 consecutive patients (aged 18–85 years) with 90 true bifurcation lesions (hemadostenosis ≥70%; bifurcation angle <90°; Medina classification 1.1.1, 1.0.1, or 0.1.1) who underwent percutaneous coronary intervention (PCI) at the Zhongshan Hospital Affiliated to Dalian University (China) between January 2013 and May 2016. The patients were randomly divided into the BSKT (44 patients, 45 lesions) and JWT (45 patients, 45 lesions) groups. The intervention was conducted according to technical requirements using a single-stent strategy. Operative success rate, occurrence of complications, postoperative quantitative coronary angiography, and incidence of perioperative and long-term major adverse cardiovascular events (MACEs) were compared between groups. The intervention success rate was 100% in both groups. After main-branch stenting, the BSKT was associated with significantly lower rates of side-branch occlusion (0% vs 15.6%, P < .05) and side-branch post-processing (8.9% vs 26.7%, P < .05) than the JWT. The BSKT was associated with significantly lower degrees of postoperative proximal main-branch residual stenosis (6.1 ± 5.1% vs 9.6 ± 8.6%, P < .05) and side-branch ostial stenosis (51.6 ± 20.6% vs 70.3 ± 20.8%, P < .05) than the JWT. The incidence of perioperative MACEs was significantly lower in the BSKT group than in the JWT group (0% vs 13.3%, P < .05). Patients were followed for a mean duration of 19.0 ± 6.1 months. The occurrence rates of long-term MACEs, angina of Canadian Cardiovascular Society grade ≥2, and severe heart failure were not significantly different between groups. The BSKT is a safe and effective technique that may have advantages over the JWT with regard to protection of the side-branch during PCI for bifurcation lesions.
Estimating the Serial Interval of the Novel Coronavirus Disease (COVID-19): A Statistical Analysis Using the Public Data in Hong Kong From January 16 to February 15, 2020

Background: The emerging virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a large outbreak of novel coronavirus disease (COVID-19) since the end of 2019. As of February 15, there were 56 COVID-19 cases confirmed in Hong Kong since the first case with symptom onset on January 23, 2020. Methods: Based on the publicly available surveillance data in Hong Kong, we identified 21 transmission events as of February 15, 2020. An interval censored likelihood framework is adopted to fit three different distributions including Gamma, Weibull, and lognormal, that govern the serial interval (SI) of COVID-19. We selected the distribution according to the Akaike information criterion corrected for small sample size (AICc). Findings: We found the lognormal distribution performed slightly better than the other two distributions in terms of the AICc. Assuming a lognormal distribution model, we estimated the mean of SI at 4.9 days (95% CI: 3.6–6.2) and SD of SI at 4.4 days (95% CI: 2.9–8.3) by using the information of all 21 transmission events. Conclusion: The SI of COVID-19 may be shorter than the preliminary estimates in previous works. Given the likelihood that SI could be shorter than the incubation period, pre-symptomatic transmission may occur, and extra efforts on timely contact tracing and quarantine are crucially needed in combating the COVID-19 outbreak.
Probabilistic reconstruction of measles transmission clusters from routinely collected surveillance data

Pockets of susceptibility resulting from spatial or social heterogeneity in vaccine coverage can drive measles outbreaks, as cases imported into such pockets are likely to cause further transmission and lead to large transmission clusters. Characterizing the dynamics of transmission is essential for identifying which individuals and regions might be most at risk. As data from detailed contact-tracing investigations are not available in many settings, we developed an R package called o2geosocial to reconstruct the transmission clusters and the importation status of the cases from their age, location, genotype and onset date. We compared our inferred cluster size distributions to 737 transmission clusters identified through detailed contact-tracing in the USA between 2001 and 2016. We were able to reconstruct the importation status of the cases and found good agreement between the inferred and reference clusters. The results were improved when the contact-tracing investigations were used to set the importation status before running the model. Spatial heterogeneity in vaccine coverage is difficult to measure directly. Our approach was able to highlight areas with potential for local transmission using a minimal number of variables and could be applied to assess the intensity of ongoing transmission in a region.
Respiratory Aspects of Approach to Neonatal Resuscitation

Introduction: Around 10% of live births globally require immediate intervention, and 4 million neonatal deaths happen in a year, where one fourth of them are due to asphyxia. Regular respiration may fail to achieve spontaneously in about ten percent of live births, with one percent of cases needing resuscitation with chest compressions, and about 0.06% needing epinephrine. The target in neonatal resuscitation is to achieve sufficient functional residual capacity, while avoiding pulmonary damage, and to optimize the tissue delivery of oxygen without causing toxicity Methodology: We conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE, January 1985, through February 2017. The following search terms were used: neonatal asphyxia, neonatal resuscitation, neonatal intensive care, respiratory distress syndrome, complications of prematurity, oxygen therapy, neonatal ventilation Aim: In this review, we aim to study the various approach taken to provide immediate resuscitation to neonates with respect to respiratory distress. Conclusion: With advancing research, physicians should have more devices to decrease the mortality rates among infants. We also need more research to establish best recommendations and guidelines on the use of best interventions especially in clinical setting with limited resources.
Drug resistance, R plasmids and pigmentation of Serratia marcescens isolated in Taiwan.

: The Serratia marcescens isolates used in this study were resistant to ampicillin, tetracycline or cephalothin, streptomycin, tobramycin, kanamycin, carbenicillin, chloramphenicol and gentamicin in descending order. Nalidixic acid was the most effective antibiotic against S. marcescens, followed by amikacin and sulfamethoxazole-trimethoprim. The non-pigmented plasmid-carrying isolates displayed higher resistance to some antimicrobial agents than did the pigmented isolates and plasmid-free white isolates. Nine out of 12 resistant markers were coded by plasmids in S. marcescens. The average number of resistant markers per strain was seven for plasmid-containing white isolates as compared to four for other S. marcescens groups. About 73% of S. marcescens contained plasmids. Thirty eight percent of plasmid-carrying S. marcescens spread their R plasmids to E. coli. Conjugative R plasmids were identified in six out of 17 strains of S. marcescens, which apparently contained a single plasmid.
Aerosol and surface stability of HCoV-19 (SARS-CoV-2) compared to SARS-CoV-1 6

HCoV-19 (SARS-2) has caused >88,000 reported illnesses with a current case-fatality ratio of ~2%. Here, 33 we investigate the stability of viable HCoV-19 on surfaces and in aerosols in comparison with SARS- 34 CoV-1. Overall, stability is very similar between HCoV-19 and SARS-CoV-1. We found that viable virus 35 could be detected in aerosols up to 3 hours post aerosolization, up to 4 hours on copper, up to 24 hours on 36 cardboard and up to 2-3 days on plastic and stainless steel. HCoV-19 and SARS-CoV-1 exhibited similar 37 half-lives in aerosols, with median estimates around 2.7 hours. Both viruses show relatively long viability 38 on stainless steel and polypropylene compared to copper or cardboard: the median half-life estimate for 39 HCoV-19 is around 13 hours on steel and around 16 hours on polypropylene. Our results indicate that 40 aerosol and fomite transmission of HCoV-19 is plausible, as the virus can remain viable in aerosols for 41 multiple hours and on surfaces up to days. decay rates of viable virus titers using a 88 Bayesian regression model. This modeling approach allowed us to account for differences in initial 89 inoculum levels across replicates, as well as interval-censoring of titer data and other sources of 90 experimental noise. The model yields estimates of posterior distributions of viral decay rates and half- 91 lives in the various experimental conditions – that is, estimates of the range of plausible values for these 92 parameters given our data, with an estimate of the overall uncertainty. 17 We describe our modeling 93 approach in more detail in the Supplemental Materials.
MOVI-daFIT! Intervention

Introduction: High-intensity interval training (HIIT) programs have demonstrated positive effects on cardiorespiratory fitness and cardiometabolic parameters, but their impact on other health parameters (such as body mass and fat) and cognition remains unclear. This paper presents the rationale and methods of a HIIT after-school physical activity (PA) intervention (MOVI-daFIT! ) on reducing fat mass and cardiovascular risk, and improving physical fitness, executive function, and academic achievement among children aged 9 to 11 years old. Methods: A cluster randomized controlled trial (RCT), including 10 schools from Cuenca province, Spain, was designed. Schools were randomly assigned to the MOVI-daFIT! intervention and to the control group. Children were evaluated at the beginning (September 2017) and at the end (June 2018) of the school year. Children in the intervention group were involved in 60-minute after-school sessions 4 days per week developed in the school setting. Each session consisted of 15 minutes of set-up and warm-up games, 28 minutes of games using the HIIT protocol, and 10 minutes of cool down. In addition, children in the intervention and control groups received 2 regular 50-minute physical education sessions per week, as it is compulsory by law in Spanish schools. Conclusion: This study will determine the effect of an after-school physical activity intervention (MOVI-daFIT! ), designed as a HIIT program, on reducing fat mass and cardiovascular risk, and improving fitness and cognition, including executive function and academic achievement.
JCB_201411047 1..17

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 208 No. 7 913–929 www.jcb. org/cgi/doi/10.1083/jcb.201411047 JCB 913 *A. El-Naggar and G. Leprivier contributed equally to this paper. Correspondence to Poul H. Sorensen: psor@mail.ubc. ca Abbreviations used in this paper: AHA, l-azidohomoalanine; CHX, cycloheximide; EMSA, electrophoretic mobility shift assay; H&E, hematoxylin and eosin; IF, immunofluorescence; IHC, immunohistochemistry; IRES, internal ribosome entry site; kd, knockdown; PB, P-body; RIP, riboimmunoprecipitation; SG, stress granule; TMA, tissue microarray. Introduction
Fast Facts: Heart Failure

Clear, informative diagrams and useful tables complement the text, and a list of key points and references for further reading are provided at the end of each chapter. It is an ideal resource for primary care providers, specialist nurses and cardiology trainees, and a good introduction to heart failure for all healthcare professionals who care for the elderly.Highlights include:a concise discussion of the pathophysiological mechanisms that lead to heart failurea detailed review of the causes and comorbidities of heart failuresimple advice on diagnosis and investigationclear management principles, including healthy lifestyle choices for patientsevidence-based guidance on firstand second-line drug therapies and medical management that targets the underlying causea comprehensive overview of non-pharmacological treatment options, including devices and transplantationimportant information on palliative care in end-stage heart failure.Fast Facts: Heart Failure is the ideal resource for primary care providers, specialist nurses and cardiology trainees, and a good introduction to heart failure for all healthcare professionals who care for the elderly.
Diversité, écologie et propriétés antifongiques des Combretaceae du Togo

Ce travail illustre la valorisation des Combretaceae a potentialites therapeutiques au Togo. L'etude phytoecologique a permis de montrer que les especes de Combretaceae sont diversement reparties dans les zones ecologiques du Togo. Elles se developpent dans les conditions ecologiques precises et sont liees a des groupements vegetaux relativement bien definis. Les especes appartenant aux genres Anogeissus, Combretum et Terminalia sont les plus repandues. L'etude antifongique a montre que les extraits hydro-ethanoliques de ces Combretaceae inhibent a des degres divers la croissance in vitro de 21 souches fongiques pathogenes. Les extraits des plantes appartenant aux genres Anogeissus, Pteleopsis et Terminalia se sont montres les plus actifs. L'analyse phytochimique sommaire a revele la presence des tanins, des flavonoides et des saponines qui pourraient etre responsables des activites antifongiques. Ces resultats justifient l'utilisation traditionnelle de la plupart de ces Combretaceae dans le traitement des dermatoses et de certaines candidoses.
Guidelines for improving HIV/AIDS communication for women in Zimbabwe

The HIV prevalence in Zimbabwe is one of the highest globally, standing at 14.5% for the ages 15-64 years, and notably 16.7% for women and 12.4% for men. The urban areas have a slightly higher prevalence rate than the rural areas in Zimbabwe. A phenomenological study was carried out whose objective was to formulate guidelines to improve HIV and AIDS communication for women in Zimbabwe, as a key contribution in mitigating the HIV epidemic. The study took place in Harare and Bulawayo, which house most of the urban population. Young urban women aged 20-29 years who have lived in either city for at least the last 12 months, were interviewed using face-to-face indepth interviews (n=25) and eight focus group discussions took place (n=62). Purposive, convenience, cluster and snow-balling sampling were used. Key informants were purposively sampled, using the snowball method; in-depth face-to-face interviews were held (n=5). The key informants, who provided expert knowledge on the study topic, comprised NGO and government entities in HIV and AIDS communication work. Colaizzi’s method of analysis was used. The UNAIDS Communication Framework for HIV and AIDS gave the direction for the study. It highlights the context in which people live in, and emphasizes that, unlike previous communication models, knowledge alone is inadequate to effect behaviour change. The context is comprised of government policy, culture, socioeconomic status, spirituality and gender relations, with emphasis on the community and regional cooperation, in Africa’s case. The themes for the study were Communication, HIV and AIDS knowledge, Perceptions and belief, and Urban women’s context. The key findings were: mass communication generates awareness for HIV and AIDS while interpersonal communication has a role to play in translating awareness into behaviour change; the knowledge level on HIV and AIDS of young urban Zimbabwean women is high; their risk perception is low; the context they live in is primarily a patriarchal one and one of urban poverty and this makes them vulnerable to HIV infection. It is envisaged that the guidelines, informed by the study and literature, will assist the government and its partners in HIV and AIDS communication strategy and implementation.