Miracle-dz/UniFAR-FTUs huggingface dataset:
Morphological alterations in the cells of the developing quail oviduct as influenced by estradiol-17 beta and the insecticide kepone: I. Observations by light and scanning electron microscopy.

Experiments were conducted to determine cellular alterations in the magnum and shell gland of undeveloped avian oviducts in response to treatment with estradiol-1713 or Kepone. Groups of immature Japanese quail females, kept in a reduced photoperiod, received injections of 40 �g estradiol-17�1/day for periods of 6-26 days while other groups were fed diets with 10, 40, 80 or 160 ppm of the estrogenic insecticide Kepone for the same duration. Both estradiol and Kepone produced an increase in oviduct weight. Estradiol accelerated cellular proliferation, cytodifferentiation and tubular gland formation and induced secretory activity in cells of the magnum and shell gland. In response to estradiol, the luminal surface exhibited increased numbers of microvilli and tubular gland depressions; the ciliation eventually became continuous and profuse. In both regions of the oviduct the cilia were well formed, tall and uniformly arranged and their tips were associated with blebs suggestive of secretory product. Ingestion of Kepone produced dose.dependent changes in oviduct structure. After Kepone ingestion, changes similar to those produced by estradiol were seen in the magnum and shell gland. However, the secretory granules were smaller and less numerous. Low levels of Kepone induced pronounced swelling of cells with extreme apical protrusions covered by microvilli and long ciiary tufts. Higher Kepone doses induced profuse, continuous ciliation; however, in contrast to the condition in the estradiol treated group, the cilia exhibited
ASSOCIATION OF TOLL-LIKE RECEPTOR GENE POLYMORPHISM WITH SOMATIC CELL SCORE IN INDIGENOUS, CROSSBRED JERSEY AND CROSSBRED HOLSTEIN FRIESIAN CATTLE

Mastitis is a disease of major economic importance, causing reduced milk quality and leading to loss of milk production in cattle. The Toll-like receptors (TLRs) 2 and 4 play a role in the host response to inflammatory mastitis. The present investigation was carried out to study the polymorphism of TLR2 and TLR4 genes in cattle, to estimate the somatic cell count in milk and to study the relationship between TLR genes polymorphism and somatic cell score in mastitis. A total of 221 blood and milk samples were collected from 114 Jersey crossbred cows and Holstein Friesian crossbred cows suffering from mastitis and from 107 healthy indigenous, Jersey crossbred and Holstein Friesian crossbred cows with no previous history of mastitis. The PCR products were sequenced and screened for SNPs. There were 24 mutations (seven non-synonymous) in TLR2 gene and 11 mutations (one non-synonymous) in TLR4 gene. The SNPs detected were genotyped using both PCRRFLP and tetra-primer ARMS-PCR. The mean SCC (x10 5 /ml) was 2.31 ± 0.10 in normal milk samples and it was 68.85 ± 3.90 in mastitis samples. The SCS was 4.01 ± 0.031 and 9.43 ± 0.69 respectively. The most common pathogens found in the milk samples were Staphylococcus, E.coli, Streptococcus, Klebsiella and Pseudomonas. Samples harboring E.coli had the highest SCC (114.57± 4.2 x10 5 /ml) when compared to others. The SNP 10095G>T of TLR2 gene influenced the SCS highly significantly. Among the three genotypes in 10095G>T, „GG‟ and „GT‟ genotypes were found to have lower mean SCS than the „TT‟ genotypes. Therefore, the GG genotypes would be resistant to mastitis.
Awareness initiative for agile business models in the Dutch mobility sector:an experience report

This report focuses on the use of agile, service-dominant business models in the mobility domain. We present a selection of business model blueprints resulted from the business modeling workshops that we executed with a diverse set of stakeholders in the domain. The results of these workshops have been elaborated and analyzed as described before in this report. From these practical actions, we derive a set of key action points that we describe in this section to fostering service-dominant business thinking in the Dutch mobility landscape. We discuss our recommendations in four categories related to respectively the strategic positioning in the domain, application of the service-dominant business paradigm in the mobility, the use of multi-sided business models, and the importance of explicit treatment of non-financial costs and benefits in business models in the domain. We end this section with a short indication of possible practical implications.
The effect of phorbol diesters on chicken embryo fibroblasts.

Summary The tumor promoter phorbol myristate acetate (PMA) at concentrations of 1 to 30 ng/ml (1.5 to 45 × 10 −9 m) had dramatic effects on chicken embryo fibroblasts (CEF). Cell morphology, size, growth, and deoxyglucose transport were among the altered properties. Of the morphological changes, the typical parallel orientation of cells on the plate was lacking for CEF grown to confluence in the presence of PMA (30 ng/ml). In sparse as well as dense cultures, PMA caused the cells to appear thinner and more elongated, with prominent processes; initial changes were discernible within 3 hr. Cell volume was decreased by PMA over the course of 2 to 3 days. The plateau value for cell volume was 62% of that of the control cultures. The exponential growth rate of CEF cultures in PMA at 50 ng/ml was not significantly altered. However, as growth rates leveled off after 3 days, cells in PMA eventually reached a 1.8-fold higher density than did those in control cultures. Resting CEF were stimulated to divide by PMA; cell number increased by 80% within 24 hr of PMA addition. The half-maximally effective dose of PMA for mitogenic stimulation was 2.3 ng/ml. PMA showed a similar half-maximally effective dose for stimulation of [ G 3 H]-2-deoxy-d-glucose uptake. Uptake reached a peak quickly, 4 to 6 hr after PMA addition, and attained a level 90% of that induced by addition of chicken serum (10%, final concentration). Stimulation of [ G - 3 H]-2-deoxy-d-glucose uptake by other phorbol derivatives was investigated. The half-maximally effective doses for phorbol 12,13-dibenzoate, 4- O -methyl phorbol 12-myristate 13-acetate, phorbol 12,13-diacetate, and phorbol 12,13,20-triacetate occurred at 5.7, 240, 405, and 6400 ng/ml, respectively, whereas phorbol itself was completely inactive at concentrations up to 20,000 ng/ml. The results lend additional support to a model for the mechanism of action of tumor promoters.
Inhibition of TGF‐β signaling by 1D11 antibody treatment increases bone mass and quality in vivo

Transforming growth factor β (TGF‐β) is an abundant bone matrix protein that influences osteoblast and osteoclast interactions to control bone remodeling. As such, TGF‐β represents an obvious pharmacologic target with the potential to regulate both bone formation and resorption to improve bone volume and strength. To investigate the skeletal effect of TGF‐β inhibition in vivo, we used an antibody (1D11) specifically directed at all three isoforms of TGF‐β. Normal mice were treated with 1D11 or control antibody (4 weeks), and cortical and trabecular bone was assessed by micro–computed tomographic (µCT) scanning. Bone volume and cellular distribution were determined by histomorphometric analysis of vertebrae and long bones. Also, whole‐bone strength was assessed biomechanically by three‐point bend testing, and tissue‐level modulus and composition were analyzed by nanoindentation and Raman microspectroscopy, respectively. TGF‐β blockade by 1D11 increased bone mineral density (BMD), trabecular thickness, and bone volume by up to 54%, accompanied by elevated osteoblast numbers and decreased osteoclasts. Biomechanical properties of bone also were enhanced significantly by 1D11 treatment, with increased bending strength and tissue‐level modulus. In addition, Raman microspectroscopy demonstrated that 1D11‐mediated TGF‐β inhibition in the bone environment led to an 11% increase in the mineral‐to‐collagen ratio of trabecular bone. Together these studies demonstrate that neutralizing TGF‐β with 1D11 increases osteoblast numbers while simultaneously decreasing active osteoclasts in the marrow, resulting in a profound increase in bone volume and quality, similar to that seen in parathyroid hormone (PTH)–treated rodent studies. © 2010 American Society for Bone and Mineral Research.
National Pension Scheme: For Whose Benefit?

Pension reforms in India in the last decade have seen three major initiatives – a paradigmatic shift in the civil servants’ pension scheme, the National Pension Scheme (NaPS) for all citizens and the New Pension System Lite for the economically disadvantaged sections with small savings. The NaPS has seen a lukewarm response so far, with a majority of subscribers being central and state government employees, for whom the scheme is mandatory. An analysis of the auto choice option under the NaPS and the demographic transition reveals potential future imbalances in the investment structure among the asset classes. Moreover, the NaPS does not even guarantee a minimum pension, thus defeating its 'welfare' orientation.
Critical Success Factors of Purchasing Polished Gemstones

The purpose of this study is to identify the critical factors impact the consumers’ decision on purchasing polished gemstones in Indonesia. Data for this study were collected from 162 respondents with varies background whitin the city of Palu in Indonesia. There were 27 indicators tested in this study. Based on the exploratory factor analysis (EFA), there are 19 indicators support the finding of critical success factors affect consumers purchasing behavior of polished gemstones in Indonesia. Indicator (X3) has the most significant factor loadings and the supporting performance (X10) has low factor loadings The indicators are segregated in the main six factors. This research has limitation in the number of respondents involved in this study. In addition, the consumers behavior in other regions of Indonesia may have different behavior so that the further study should be tested in different regions to support the findings. This paper provide data for developing the constructs in consumers behavior of luxury products. Therefore, the future research might test and analyse the factors with other constructs with the aim to a new insight in consumer behavior of luxury products. Keywords— critical success factors, consumers’ behavior, gemstones
Antipyretic Activity of Azima tetracantha in Experimental Animals

In the present study, the ethanolic leaf extract of Azima tetracantha Lam (A. tetracantha) was investigated for antipyretic activity in rats using Brewer's yeast induced Pyrexia. The leaves of A. tetracantha were collected from Ponnamaravathi and cut into small pieces and shade dried. The dried powdered leaves (100 gm) were extracted in a Soxhlet apparatus by using 95% ethanol. Albino rats weighing (200-250g) were taken for the experiment divided into four groups of six animals each. Group 1 received 3% aqueous suspension of gum Acacia (1 ml/200g) as vehicle orally, group 2 and group 3 received ethanolic leaf extract of A. tetracantha 100 and 200 mg/kg with 3% aqueous suspension of gum Acacia orally and the group 4 served as standard received paracetamol 25 mg/kg with 3% aqueous suspension of gum Acacia orally. The subcutaneous injection of yeast suspension markedly elevated the rectal temperature after 18h of administration. Treatment with A. tetracantha extract at a dose of 100, 200 mg/kg decreased the rectal temperature of the rats in dose dependent manner. This effect was maximal at dose of 200 mg/kg and it caused significant lowering of body temperature (P< 0.01) up to 4 hour after its administration. The antipyretic effect started as early as 1h and the effect was maintained for 4h, after its administration. Both the standard drug paracetamol 25 mg/kg and tested drug A. tetracantha extract were significantly reduced the yeast elevated rectal temperature, at 2nd, 3rd and 4th hour compared to control group.
The impact of rewards and remuneration practices on the retention of teachers in the North-West Province

Background and Aim The Department of Education is tasked with the responsibility to improve education in North West Province. The responsibility can only be accomplished if the Department of Education retains good and skilled teachers. The problem is that teachers are constantly leaving the country for better remuneration and reward in developed countries or are leaving the profession for other career paths. The teaching profession is occupied by aged teachers due to an inability to attract young teachers into the profession. Teachers are constantly protesting due to remuneration and reward practices of the Department of Education, working conditions and lack of development. This study investigates the state of teacher pay in the South African labour market by comparing the remuneration received by teachers with retention. This means that the study will determine and clarify if retention can be achieved and maintained by remuneration practices and rewards. Research Method A qualitative research approach was followed in this study. Data was gathered by means of semi-structured interviews with teachers (N=6) from North-West province. The data was analysed by means of content analyses. Research Findings The findings showed that the participants' were unhappy with their compensation and did not receive proper recognition. In addition the participants felt that although there are limited opportunities for career development and those available were allocated based on favouritism. Performance Management systems were also identified as poor or nonexistent. The participants were though satisfied with their work-life balance.
The Physician Quality Reporting Initiative—A Gateway to Pay for Performance: What Every Health Care Professional Should Know

The Physician Quality Reporting Initiative (PQRI) is a pay-for-reporting (P4R) program sponsored by the Centers for Medicare & Medicaid Services open to all health care providers that treat Medicare patients. This P4R initiative provides financial incentives for participation and unlike most pay-for-performance (P4P) programs, there are no penalties for poor performance. PQRI therefore offers Medicare providers nationwide a low-risk opportunity to gain experience with reporting procedures likely to be incorporated into P4P reimbursement schemes. The 74 measures used during the first reporting period are applicable to both generalist and specialist providers and open participation in PQRI to a much broader audience compared with previous federal initiatives. Also in contrast to programs that measure hospital or group quality and reimburse for services at the health system level, measurement and reimbursement in PQRI directly affects individual Medicare providers. The combination of provider-level measurement and reimbursement and efforts to assess care delivered by both generalist and specialist Medicare providers highlights how this P4R initiative is truly a gateway to a P4P reimbursement system. Participation in the PQRI program provides useful experience to Medicare providers and their staff in preparing for future initiatives that try to tie quality to reimbursement.
Low-Profile Antenna for Ten Band WWAN/ LTE/WiMAX Smartphone Applications

A small antenna which works in ten bands for slim and wide screen internal smartphone application is proposed here. It consists of a feeding strip, a coupling strip and shorting strip, which can be easily printed on the FR4 substrate. In this scheme three chip inductors and a chip capacitor are loaded on the strips. A parallel resonant circuit is introduced in the design in order to enhance the bandwidth of lower bands. This antenna has a size of 5x40mm and a height of 2mm which is promising for slim and wide screen smartphones. The proposed antenna can operate in GSM850/DCS/ PCS/UMTS2100 /LTE2300/2500/2690, WiMAX-3100/3500, Amateur radio and Bluetooth frequency bands. The design considerations and the antenna parameters are explained in detail. General Terms Antenna, WWAN/LTE/WiMAX smartphones.
Safe, Efficient Garbage Collection for C++

We propose adding safe, efficient garbage collection to C++, eliminating the possibility of storage-management bugs and making the design of complex, object-oriented systems much easier. This can be accomplished with almost no change to the language itself and only small changes to existing implementations, while retaining compatibility with existing class libraries. Our proposal is the first to take a holistic, system-level approach, integrating four technologies. The language interface specifies how programmers access garbage collection through the language. An optional safe subset of the language automatically enforces the safe-use rules of garbage collection and precludes storage bugs. A variety of collection algorithms are compatible with the language interface, but some are easier to implement and more compatible with existing C++ and C implementations. Finally, code-generator safety ensures that compilers generate correct code for use with collectors.
Role of Histomorphology and Chronic Inflammation Score in Chronic Dacryocystitis.

INTRODUCTION Diseases of lacrimal drainage system account for nearly 3% of visits to eye clinic. Chronic dacryocystitis is a frequently encountered disorder among these patients. Histomorphology of specimens obtained after Dacryocystorhinostomy (DCR) is a pertinent indicator of prognostic outcome. AIM The aim of the study was to evaluate histopathology of specimens obtained after DCR and to elucidate patterns and score of chronic inflammation encountered. MATERIALS AND METHODS The study was conducted for a period of one year. Total of 50 patients who were clinically diagnosed as Chronic Dacryocystitis and underwent DCR were included. Following DCR, specimens of lacrimal sac, nasal mucous membrane and nasal bone were collected. Histopathological slides were examined for chronic inflammatory cell infiltration, fibrosis and capillary proliferation and were graded according to severity, in each specimen. A Chronic Inflammation Score (CIS) was recorded for each case. RESULTS The average age of patients was 39.04±14.22 years and their age ranged between 13 and 62 years. There were 28 (56%) females and 22 (44%) males in the study group. The nasal bone did not reveal any abnormality in any case. The nasal mucous membrane showed mild chronic inflammatory cell infiltration in 46 (92%) cases and moderate degree in 4 (8%) patients. Chronic inflammation with granulation tissue formation was noted in lacrimal sacs of all patients. The CIS revealed that 14 (28%) cases belonged to "mild" group, 26 (52%) to "moderate" group and 10 (20%) to "severe" category. CONCLUSION The inclusion of CIS in histomorphological evaluation of DCR specimens is recommended since it is one of the parameters that influence course of the disease.
Leading indicators for prognostic health management of electrical connectors subjected to random vibration

In this paper a leading indicators of failure has been developed to monitor the progression of fretting corrosion in electrical connectors and prognosticate remaining useful life. Connectors subjected to harsh environments may experience vibration resulting in fretting corrosion and degradation in contact resistance over time. Tin coated, rectangular-pin and socket electrical connectors have been studied. Connectors are extensively used in automotive systems in conjunction with wire harnesses. Electronics may be full filling many vehicle performance critical functions including: collision avoidance, lane departure warning, supplemental restraint, and driver distraction detection. Connector degradation may cause electrical failure during or prior to vehicle operation. In this paper, a random vibration test profile has been used to stimulate the contact resistance degradation due to connector fretting corrosion. The contact resistance has been measured in situ using the resistance spectroscopy method in conjunction with phase sensitive detection. It has been shown that precise resistance spectroscopy and phase measurements can provide a leading indicator of failure significantly prior to the traditional definition of failure. Prognostic health management (PHM) is a useful tool for assessment of the remaining life of electrical components, and is demonstrated for electrical connectors in this paper. The ability to predict the remaining useful life of a connector can benefit operators with the knowledge of when to schedule preventative maintenance, aid in the cost optimization of operations and products and increase safety by providing advanced warning of potential critical failures. The presented approach can be used for assessment of damage accrual in connectors systems in the pre-failure space and prognosticate remaining useful life. Impending failure can be identified prior to both intermittent and catastrophic failure. Repeatability of the setup and the robustness of the unique PHM prediction algorithms have been quantified.
A new phase of activity of the Herbig Be star HD 200775 in 2001: Evidence for binarity

The results of high-resolution spectroscopy of the Herbig Be star HD 200775 obtained within the framework of a cooperative observing programme in 2000–2002 are presented. A new high-activity phase of the object’s Ha line occurred in the middle of 2001 in full agreement with a 3.68-year periodicity predicted by Miroshnichenko et al. (1998). A complicated picture of the Ha line profile variability near the activity maximum phase turned out to be very similar to that observed during the previous one in 1997. Variations of the radial velocity with the activity phase are detected in He I, Si II, and S II photospheric lines. The observed phenomena are interpreted in the framework of a model in which the star, together with its gaseous envelope, is a component of an eccentric binary system. A preliminary orbital solution is derived, and the system’s parameters are estimated from the radial velocity curves of the Ha emission line. We find that the orbital eccentricity is e ~ 0.3, the mean companion separation is ~1000 R? , and the secondary companion is most likely to be a ~3.5 M, pre-main sequence object. We emphasize the importance of coordinated spectroscopic and interferometric observations at different phases of the object’s activity for further understanding the properties of the system.
The Relationship between Psychological Climate and Faculty-Administrator Trust in Departments of Marketing and Management

The ability of academic administrators to develop and preserve trusting relationships with faculty likely exerts a substantial influence on the quality of faculty performance. The authors investigate the extent to which the psychological climates of marketing and management departments influence the level of trust that faculty place in their administrators. They conclude with recommendations regarding how administrators can foster a trust-facilitating psychological climate.
Expanding Responsibilities of Corporate Governance: The Incorporation of CSR and Sustainability

Traditionally, directors’ responsibilities have been to the members (shareholders) of the company. But in the 21st century a view has arisen that they have responsibilities to a wider group of interested parties. Different philosophical approaches support the alternative views about corporate governance. These philosophical underpinnings will be examined. Also, evidence of directors’ responsibilities to the wider community will be illustrated through a national survey of directors in New Zealand. Increasingly, it seems that good corporate governance will involve an expanded view of the responsibilities of company directors. The laissezfaire, free market philosophy has been tempered by a realization that the firm is a part of a wider environment. It is becoming accepted by a large proportion of business firms that the well being of the firm is tied to the well being of the environment, at least in the longer term perspective.