Miracle-dz/UniFAR-FTUs huggingface dataset:
Estimation of the Economic Impact of a Unit Change in Predicted Transmitting Ability for Daughter Pregnancy Rate and Other Predicted Transmitting Ability in the Merit Indexes

These studies deal with lifetime profit analyses for individual cows, and using these estimates to determine the economic value of genetic changes in traits for which genetic evaluations (predicted transmitting ability, PTA) are currently available. Data were collected from six states processed by Dairy Records Management Systems (DRMS) from herds on continuous test for at least 10 yr. The purpose of the first study was to determine how well estimators of lifetime net income based on 305-d lactation yields and a 10-yr opportunity (RNI305.10) and based on complete lactation data but a 5-yr opportunity (RNIc.5) predict the estimate based on complete lactations and a 10-yr opportunity (RNIc.10). Records for 22,854 cows in Virginia herds born in 1988, 1990, and 1992 from the DRMS in Raleigh, NC were used. Each RNI was calculated using fluid (skim/fat) pricing and milk-fat-protein pricing. Regression analyses including herd and birth year were used in the model to estimate the regression of RNIc.10 on RNIc.5, and RNIc.10 on RNI305.10. The resulting regression coefficients for fluid (skim/fat) pricing were $1.53 and $1.12 explaining 67 and 97% of the variation of RNIc.10, respectively. The corresponding results for milk-fat-protein pricing were $1.52 and $1.14 explaining 68 and 96% of the variation of RNIc.10, respectively. Using RNIc.10 as the measure to estimate lifetime profit is strongly recommended over the two alternatives tested. In the second study, the economic impacts of a unit change in PTA of daughter pregnancy rate (DPR) and other PTA in the merit indexes on lifetime profit estimates of a bull’s daughters were estimated to determine an economic weight for the PTADPR and other PTA in economic indexes. Records for 71,094 cows born in 1988, 1990, and 1992 from six states processed at DRMS were used: Florida [10,940 cows], Indiana [8,231
Association analysis of APOA 5 rs 662799 and rs 3135506 polymorphisms with obesity in Moroccan patients Analyse d ’ association des polymorphismes rs 662799 et rs 3135506 du gène APOA 5 avec l ’ obésité chez des patients marocains

The aim of the present study is to explore the association between the APOA5 polymorphisms and haplotypes with obesity in Moroccan patients. The study was performed in 459 subjects, Obese (n = 164) and non-obese (n = 295). All subjects were genotyped for the APOA5 -1131T > C (rs662799) and c.56C > G (rs3135506) polymorphisms. The contribution of APOA5 polymorphisms and haplotypes in the increased risk of obesity were explored using logistic regression analyses. The -1131T > C and c.56C > G polymorphisms were significantly associated with obesity. Both polymorphisms were strongly associated with increased BMI. Analysis of constructed haplotypes showed a significant association between CG haplotype and susceptibility to obesity (OR [95%CI] = 3.09 [1.93–4.97]; P < 0.001). These results support a potential role for APOA5 common variants and related haplotypes as risk factors for obesity. 2015 Elsevier Masson SAS. All rights reserved.
Reciprocity Scheme Approach to Free-Riding Evasion in Grid System

The crucialrule of Grid systems is intentional resource sharing among individual Grid users.However; there is an intrinsicfriction between individual prudence and collective welfare that threatens the viability of these systems. Grid systems have emerged as a popular alternative to traditional client-server architectures for resourcesdistribution and sharing. Different academic studies have observed high levels of free-riding in various Grid systems, leading some to suggest the imminent collapse of these systems as viable resource sharing mechanism. This observable fact was due to hidden-action, hidden information as well as betrayer of co-operation and confidence among the selfish participating users with diverse malicious intentions. In Grid system, the supply and demand theory is symbiotic since the supplier of resources to other users within the system also demands for resources supplied by others. Generally, this paper investigated into the intersection of economics and computer science in the designing of Grid systems that consisting of rational participants with diverse and egocentric interests.This diversity behaviour usually led to free-riding which is a great hindrance to the achievement of the objectives of Grid system.This papertherefore develops an analytic model to analyze the behaviour of different users with different intentionsin Grid system. Reciprocity-based schemes that premised on incentive mechanisms and user’sco-operation was applied to address the problem of free-riding. In all, forty-five simulations were carried out under each parameter (i.e. storage space, memory and bandwidth). Before arriving at the result, various values of α used are; 0.05, 0.1, 0.5, 0.9, 1.0, 1.05, 1.1, 1.5 and 2.0 where α is the resource utilization determinant of the system. The proposed scheme performed optimally when α = 1. In the control experiments, it was observed that immediately the value of α is greater than 1, no matter how small, there exists contention and free-riding eventually ensue in the system. However, the value of α under the proposed scheme can never be greater than 1;since 0 < α ≤ 1. This circumstance is being controlled and managed by the formulated policy engine and access control mechanism of the scheme.
Pacific Asia Conference on Information Systems ( PACIS ) July 2008 Application Access Control using Enterprise Models

In this paper a framework for a model-driven control of identity management systems is presented. An important issue in today’s information systems security discussion addresses the effective authorisation of users. With established conceptual modelling languages the assignment of roles to the identity management software is an enormous organisational effort. To decrease administration costs we propose a direct connection between the identity management system and enterprise models which contain the organisational responsibilities. Therefore, we have created the modelling approach E3+WS available for the meta-CASE tool cubetto toolset and the Novell Identity Manager.
hierarchical text classification External methods to address limitations of using global information on the narrow-down approach for

Classifying documents to a large-scale web taxonomy is a challenging research problem because of a large number of categories and associated documents in the taxonomy. The state-of-the-art solution known as the narrow-down approach utilizes a search engine to reduce an entire category hierarchy to most relevant categories and selects the best one among them using a classifier. In a recent language modelling approach, top-level category information (or global information) was used in judging the appropriateness of a local category, which led to performance improvements. However, we observe that using global information has a limited influence on the final category selection under some conditions. First, global information may be inaccurate even though it is generated by a top-level category classifier using an entire hierarchy. Second, it has little influence when two competing categories share the same top-level category or when the local category information has too strong an influence on the final category selection. To resolve the limitations, in this paper, we propose two external methods: (1) a meta-classifier with novel dependency features among top-level categories based on an ensemble learning framework; and (2) a query modification model based on a statistical feedback method to improve the query document representation instead of just juggling with information in the hierarchy. Our methods were evaluated using the Open Directory Project test collection.
Green Building Handbook for South Africa Chapter : The environmental impacts of construction materials use : a life cycle perspective

The main focus of improvement efforts are the building assessment and rating systems of the green building movement which have yielded considerable success. Energy and water consumption have been reduced considerably. However, these efforts are informed by perceptions rather than scientific facts. Materials selection has remained a particularly difficult and contentious issue. For instance, the use of wood from well-managed forests reduces the consumption of non-renewable resources but the fertilisers, pesticides and herbicides used in crop production processes contain heavy metals which may end up in the food chain. Current approaches also encourage problem shifting. For instance, construction is one of the largest users of energy, raw materials and water. However, energy efficiency and water conservation are prioritised on the green agenda while the key environmental impacts associated with materials use, namely, depletion of resources; and releases of solid and liquid wastes and toxic emissions to air are barely addressed.
recovery of stroke patients : a systematic review and meta-analysis The effect of altering a single component of a rehabilitation programme on the functional

Objective: To evaluate the effect of altering a single component of a rehabilitation programme (e.g. adding bilateral practice alone) on functional recovery after stroke, defined using a measure of activity. Data sources: A search was conducted of Medline/Pubmed, CINAHL and Web of Science. Review methods: Two reviewers independently assessed eligibility. Randomized controlled trials were included if all participants received the same base intervention, and the experimental group experienced alteration of a single component of the training programme. This could be manipulation of an intrinsic component of training (e.g. intensity) or the addition of a discretionary component (e.g. augmented feedback). One reviewer extracted the data and another independently checked a subsample (20%). Quality was appraised according to the PEDro scale. Results: Thirty-six studies (n = 1724 participants) were included. These evaluated nine training components: mechanical degrees of freedom, intensity of practice, load, practice schedule, augmented feedback, bilateral movements, constraint of the unimpaired limb, mental practice and mirrored-visual feedback. Manipulation of the mechanical degrees of freedom of the trunk during reaching and the addition of mental practice during upper limb training were the only single components found to independently enhance recovery of function after stroke. Conclusion: This review provides limited evidence to support the supposition that altering a single component of a rehabilitation programme realises greater functional recovery for stroke survivors. Further investigations are required to determine the most effective single components of rehabilitation programmes, and the combinations that may enhance functional recovery.
Effectiveness of oral baclofen for spasticity in children with cerebral palsy

1 Objective: To systematically review the effectiveness of oral baclofen versus placebo 2 or other antispastic oral medication in the areas of body function, activity, and quality of 3 life in children with spastic CP ≤ 18 years. Study Selection: randomized or not 4 randomized controlled clinical trials (RCT) and cohort studies were selected, comparing 5 the effect of any dose of oral baclofen with no treatment, placebo, or another antispastic 6 medication in children with spastic CP. Data Sources : The Cochrane library, Health 7 Science Databases, DARE, Lilacs, Embase, Medline, OTSeeker, PEDro, PsycINFO, 8 SpeechBITE, ScienceDirect, Scopus, Trip, clinicaltrial.gov, Google scholar, OpenGrey 9 and manual search. Data Extraction: Following the Cochrane Handbook for 10 Systematic Reviews of Interventions Guidelines, two reviewers independently classified 11 articles through October 2014. Data synthesis: Six RCT were selected involving 130 12 participants. Studies show a great variability in motor classification, dosage of baclofen, 13 and outcomes measurements. There is conflicting evidence regarding the effectiveness 14 of oral baclofen in reducing muscle tone, improving motor function or the level of 15 activity. The overall methodological quality of the studies was low. Main qualitative 16 deficiencies correspond to serious risk of bias, inconsistency of results, unpowered 17 sample size, and publication bias. Conclusions: There are insufficient data to support or 18 refute the use of oral baclofen in children with spastic CP. PROSPERO 2014: 19 CRD42014013658. 20
Short title : zebrafish DNT for human risk assessment

The developing brain is extremely sensitive to many chemicals. Exposure to neurotoxicants during development has been implicated in various neuropsychiatric and neurological disorders, including autism spectrum disorder, attention deficit hyperactive disorder, schizophrenia, Parkinson’s disease, and Alzheimer’s disease. Although rodents have been widely used for developmental neurotoxicity testing, experiments using large numbers of rodents are time-consuming, expensive, and raise ethical concerns. Using alternative non-mammalian animal models may relieve some of these pressures by allowing testing of large numbers of subjects while reducing expenses and minimizing the use of mammalian subjects. In this review, we discuss some of the advantages of using zebrafish in developmental neurotoxicity testing, focusing on central nervous system development, neurobehavior, toxicokinetics, and toxicodynamics in this species. We also describe some important examples of developmental neurotoxicity testing using zebrafish combined with gene expression profiling, neuroimaging, or neurobehavioral assessment. Zebrafish may be a systems toxicology model that has the potential to reveal the pathways of developmental neurotoxicity and to provide a sound basis for human risk assessments.
Based on Users Check-in History for Location-Based Services

With rapid growth of the GPS enabled mobile devices, location-based online social network services become very popular, and allow their users to share life experiences with location information. In this paper, we considered a method for recommending places to a user based on spatial databases of locationbased online social network services. We used a user-based collaborative filtering method to make a set of recommend places. In the proposed method, we calculate similarity of users’ check-in activities based on not only their positions but also their semantics such as “shopping”, “eating”, “drinking”, and so forth. We empirically evaluated our method in a real database and found that the proposed method outperforms the naive singular value decomposition collaborative filtering in its recommendation accuracy.
Life cycle fragments: development of an online tool for curating and sharing life

Increasingly, policy makers and consumers demand information on the environmental implications of industrial activities. Life cycle assessment (LCA) is a standardized methodology to relate the delivery of products and services to the potential environmental impacts from that delivery, both directly and throughout the industrial supply chain. LCA requires extensive information about industrial processes throughout the global economy, and is subject to substantial parametric and epistemic uncertainty. Moreover, results often hinge on modeling decisions, such as the selection of system boundaries and data sources, leading to complications when validating results or comparing study outcomes. Comparative results from a single study can give policy-relevant insights only if it is possible to review the sensitivity of results to both uncertainty and modeling decisions. After completing an LCA study for the state of California to inform policy on waste lubricating oil management, we were motivated to develop a data framework for formally describing life cycle inventory models and allowing them to be inspected and analyzed. A “life cycle fragment” describes a network of dependencies among industrial processes with a limited scope and simple formal structure, simplifying the computation of LCA results. Efforts to construct an online tool implementing the fragment framework for use by policy makers, stakeholders, and the general public are ongoing. The tool will facilitate use of the model to analyze parametric uncertainty and model design, thus improving transparency and communicability of the model’s results to interested parties.
systematic review and meta-analysis Relative efficacy of antianginal drugs used as add-on therapy in patients with stable angina : A

Aims: First-line medical management of stable angina generally involves a beta-blocker (BB) or calcium channel blocker (CCB), with other classes of medication being added if symptom control is inadequate. Evidence supporting the appropriate choice of a second-line agent is currently unclear. The objective of this systematic review was to quantify the clinical benefit of BB, CCBs, long-acting nitrates (LANs), ranolazine, trimetazidine, ivabradine or nicorandil added to firstline monotherapy for stable coronary artery disease. Methods: Randomised controlled trials comparing the efficacy of antianginal therapies in patients with stable angina refractory to first-line therapy were identified from a literature search. Exercise tolerance test (ETT) data and clinical outcomes were extracted and combined in a series of meta-analyses. Results: A total of 46 qualifying studies were identified, evaluating 71 treatment comparisons. The combination of ranolazine added to CCB or BB showed positive outcomes across all outcomes assessed. Other combinations of BB, CCB, LAN and trimetazidine showed significant benefits for most but not all outcomes. Ivabradine demonstrated benefits for ETT assessments but these were not matched in clinical domains. No qualifying studies were identified for nicorandil in an add-on role. Conclusion: Across a range of commonly assessed exercise and clinical outcomes, the effectiveness of BBþCCB used in combination is broadly confirmed. Ranolazine used with BB or CCB showed benefits across all outcomes assessed, while LAN and trimetazidine used with BB or CCB have shown benefits across some outcomes. Ivabradine added to BB shows inconsistent effects from a single study, whilst there is no relevant evidence for nicorandil.
Stratification , and Primary Prevention Sudden Cardiac Death Early After Myocardial Infarction : Pathogenesis , Risk

Stratification, and Primary Prevention Sudden Cardiac Death Early After Myocardial Infarction: Pathogenesis, Risk Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2014 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.113. 007497 2014;129:2426-2435 Circulation. http://circ.ahajournals. org/content/129/23/2426 World Wide Web at: The online version of this article, along with updated information and services, is located on the
Human Mesenchymal Stem Cell Transfusion for End Stage Liver Disease:A Case Series and Literature Review

Decompensated liver cirrhosis is a severe, life-threatening situation in end-stage liver disease. Liver transplantation is the only effective therapy regarding on this. Unfortunately the shortage of liver donors, vast of patients died during enrolled in the waiting list. There are increasing reports of using stem cell to treat advanced liver disease nowadays worldwide, and if it could be alternative therapy in persons with end-stage liver disease is not so clear. Herein we describe a case series outcome of Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs) transfusions for decompensated liver cirrhosis and also reviewed the literature on stem cell therapy.
An Update on Treatment of Hepatitis C Virus Genotype 1 Infection and Viral Load Assessments To the

According to the recently released American Association for the Study of Liver Diseases (AASLD) guidelines for the treatment of hepatitis C virus (HCV) genotype 1 chronic infection, in treatment-naı̈ve subjects the association of boceprevir or telaprevir with peginterferon-alpha and ribavirin is strongly recommended as the optimal therapy. In patients treated with boceprevir, peginterferon, and ribavirin, a response-guided treatment schedule was established at week 8, through the assessment of HCV RNA level, making feasible a shortened duration of treatment (i.e., 28 weeks) in the case of undetectable viral replication. In this regard, we believe that the choice of 8 weeks for the definition of treatment duration needs some comment. The phase 2 and 3 clinical trials with boceprevir featured the use of peginterferon-ribavirin for 4 weeks (the lead-in period) before boceprevir was added. The reasons for starting with a lead-in phase would be to lower HCV-RNA before exposure to a protease inhibitor in order to reduce the risk of resistance and viral breakthrough. However, in the studies mentioned the achievement of virologic response after the lead-in therapy (4 weeks) was shown to be highly effective for the prediction of sustained virologic response (SVR; HCV-RNA undetectability leading to SVR in a percentage of patients between 89% and 100%, independently from the treatment arm). Indeed, Poordad et al. stated that in patients with undetectable HCV RNA levels after the lead-in period, boceprevir administration would not result in a higher rate of SVR than that obtained with the use of standard therapy. Therefore, the lead-in period as well as interleukin (IL)-28B genotype assessment might be used to better define the eligible patients for peginterferon introduction, thus avoiding their possible overuse with additional costs and side effects. In our opinion, it seems to be reasonable to reconsider the assessment of HCV-RNA at week 4 (end of lead-in) in the response-guided treatment guidelines of naı̈ve genotype-1-infected patients.
First hyperfine resolved far-infrared OH spectrum from a star-forming region

OH is an important molecule in the H2O chemistry and the cooling budget of star-forming regions. The goal of the Herschel key program 'Water in Star-forming regions with Herschel' (WISH) is to study H2O and related species during protostellar evolution. Our aim in this letter is to assess the origin of the OH emission from star-forming regions and constrain the properties of the emitting gas. High-resolution observations of the OH 2Pi1/2 J = 3/2-1/2 triplet at 1837.8 GHz (163.1 micron) towards the high-mass star-forming region W3 IRS 5 with the Heterodyne Instrument for the Far-Infrared (HIFI) on Herschel reveal the first hyperfine velocity-resolved OH far-infrared spectrum of a star-forming region. The line profile of the OH emission shows two components: a narrow component (FWHM approx. 4-5 km/s) with partially resolved hyperfine structure resides on top of a broad (FWHM approx. 30 km/s) component. The narrow emission agrees well with results from radiative transfer calculations of a spherical envelope model for W3 IRS 5 with a constant OH abundance of approx. 8e-9. Comparison with H2O yields OH/H2O abundance ratios of around 1e-3 for T > 100 K and around unity for T 0.028 in the outflow is derived from comparison with results of water line modeling. This ratio can be explained by a fast J-type shock or a slower UV-irradiated C-type shock.