Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Stakeholders’ Background on Perceptions of Usability and Usefulness on Personal Health Records

Supervisory Committee Dr. Andre Kushniruk, School of Health Information Science Supervisor Dr. Elizabeth Borycki, School of Health Information Science Departmental Member Despite rapid advances in technology, there is currently a complex, and somewhat disjointed approach to the way health information is collected, stored, and organized for both healthcare consumers and professionals. Incompatible electronic medical records from various healthcare providers add to the complexity of a system tasked with delivering a patient’s relevant medical information in a timely manner to the appropriate point of care. Personal health records (PHR) grew out of the efforts to produce an integrated electronic record to manage the multifaceted aspects of healthcare required by both healthcare consumers and professionals. PHRs are a transformative technology with the potential to alter patient-provider relationships in a way that produces a more efficient and cost effective healthcare system as a result of better patient outcomes. PHRs can potentially include a wide variety of users ranging from the lay public to clinical professionals. As such, it is important to identify potential user groups and their corresponding health information needs in order to design PHRs that maximize accessibility, usability, and clinical relevance.
FSSE: An Effective Fuzzy Semantic Searchable Encryption Scheme Over Encrypted Cloud Data

Currently, searchable encryption has attracted considerable attention in the field of cloud computing. The existing research mainly focuses on keyword-based search schemes, most of which support the exact matching of keywords. However, keyword-based search schemes ignore spelling errors and semantic expansions of keywords. The significant drawback makes the existing techniques unsuitable in cloud computing as it greatly affects system usability and can not completely satisfy the users’ search intentions. In this paper, we propose an effective fuzzy semantic searchable encryption scheme (FSSE) that supports multi-keyword search over encrypted data in cloud computing. In our scheme, we exploit a keyword fingerprint generation algorithm to generate a fingerprint set of the keyword dictionary and a fingerprint of the query keywords, and employ Hamming distance to quantify keywords similarity. Based on the proposed fingerprint generation algorithm and Hamming distance, we realize fuzzy search. Furthermore, we utilize the semantic expansion technique to expand query keywords and calculate the semantic similarity between the query keywords and the expanded word of the query keywords to achieve the semantic search. To improve the search efficiency, we construct an inverted index structure and use the vector intersection matching as well as short-circuit matching operations to effectively filter irrelevant documents. The theoretical analysis and experimental results demonstrate that our proposed scheme satisfies the security guarantee of searchable encryption, enhances system usability, and is more efficient in comparison with the state of the art schemes.
Context matters: How do task demands modulate the recruitment of sensorimotor information during language processing?

Many theories of semantic representation propose that simulations of sensorimotor experience contribute to language processing. This can be seen in the body-object interaction effect (BOI; how easily the human body can interact with a word’s referent). Words with high BOI ratings (e.g., ball) are processed more quickly than words with low BOI ratings (e.g., cloud) in various language tasks. This effect can be modulated by task demands. Previous research established that when asked to decide if a word is an object (entity condition), a BOI effect is observed, but when asked to decide if a word is an action (action condition), there is no BOI effect. It is unclear whether the null behavioral effect in the action condition reflects top-down modulation of task-relevant sensorimotor information or the absence of bottom-up activation of sensorimotor simulations. We investigated this question using EEG. In Experiment 1 we replicated the previous behavioral findings. In Experiment 2, 50 participants were assigned to either the entity or action conditions and responded to the same word stimuli. In both conditions we observed differences in ERP components related to the BOI effect. In the entity condition the P2 mean amplitude was significantly more positive for high compared to low BOI words. In the action condition the N400 peak latency was significantly later for high compared to low BOI words. Our findings suggest that BOI information is generated bottom-up regardless of task demands and modulated by top-down processes that recruit sensorimotor information relevant to the task decision.
Abstract 1298: CD40L-CD40 signaling on B-cell lymphoma response to BTK inhibitors

The aberrant activation of B cells receptor (BCR) signaling plays an essential role in the pathogenesis of B-cell lymphomas. Targeting BCR signaling by inhibiting Bruton9s tyrosine kinase (BTK) has been shown to be a successful strategy in treating B-cell lymphomas including mantle-cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL). Ibrutinib, an oral, covalent BTK inhibitor achieved high overall response rate (ORR) and prolonged duration of responses in CLL and MCL patients. In contrast, ibrutinib was reported to have much lower response rate in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) and the responses in DLBCL was restricted to the activated B-cell (ABC) subtype. These differences highlight the need to understand the bypass signaling/pathway to BTK inhibition. In this study, we identified CD40L-CD40 pathway as one of the potential bypass pathways to BTK inhibitory therapy. We showed that CD40 was consistently expressed in mature B cells, whilst CD40L expression levels were heterogenic in tissue microarray (TMA) with 150 lymphoma samples. In these samples, circa 57% of lymphoma tissues have medium or strong level of CD40L expression in TMA, indicating the existence of CD40L-CD40 signaling in human lymphoma tissues. Consistent with the response rate of ibrutinib in patients, in 68 non-GCB type of DLBCL, in which aberrant activation of NF-kB pathway is important for the pathogenesis, about 60% samples showed CD40L expression. Co-culture of Rec-1 or TMD8 cells with HEK293/CD40L attenuated the anti-proliferation activity of ibrutinib in vitro. This observation was also confirmed with recombinant soluble CD40L protein. Detailed mechanistic analysis revealed that CD40L-CD40 signaling activated the NF-κB and MAPK pathway and offset the inhibition of ibrutinib. Additionally, activating NF-κB pathway with PKC agonist abolished the cell killing effects of ibrutinib. These data suggest CD40L may be used as a potential biomarker for studying clinical responses to BTK inhibitors. Additionally, our results support combination strategies of BTK inhibitors with agents blocking CD40 or downstream NF-κB and MAPK pathway in patient population where CD40L-CD40 pathway is activated. Citation Format: Zhijian Sun, Lusong Luo. CD40L-CD40 signaling on B-cell lymphoma response to BTK inhibitors. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1298.
Adsorption Performance of Modified Sponge Gourd for Crude Oil Removal

This study determined the adsorption ability of modified sponge gourd fibre in adsorbing crude oil from simulated oil-water mixture. Modification was done on the adsorbent by treating with hot water and sodium hydroxide. The dependence of the adsorption process on particle size of the fibre was determined using mesh sizes of 4.75, 2.36, 1.18 and 0.85 mm. The hot water treatment significantly increased the adsorbing ability of the sponge gourd, removing 83.3% of the crude oil from the mixture, alkaline treated sample removed 45.1% and the raw sample removed 22.9%. The result of the SEM images shows that hot water treated sample has more pores on the surface which influenced the better performance. The FTIR results obtained after the adsorption show the successful adsorption of crude oil on to the surface of the sponge gourd due to the presence of functional groups characteristics of groups found in crude oil. An optimum particle size for the sponge gourd was found to exist at the value of 1.18 mm, above and below which the crude oil removed was reduced. The modification of sponge gourd promoted the adsorption capacity for crude oil.
Study of modifiable risk factors associated with learning abilities in MBBS students

Introduction: Healthy body is the basis for healthy mind and sound learning. Factors affecting physical health can influence one’s learning abilities. BMI, neck girth, breakfast eating habits, resting blood pressures are surrogates of physical health; when they err different learning skills may go hayward. Materials and Methods: A cross-sectional study was carried out on first year medical students in a medical college in western part of central India. 127 complete entries were evaluated by ‘Metacognitive Awareness Inventory’. Obesity was assessed by BMI and Neck Circumference, and resting blood pressure measured by standing mercury sphygmomanometer. Breakfast eating behaviour was assessed by semi structured close-ended questionnaire. The data were coded and analysed by SPSS version 20. The level of significance was assigned at p Results: On Pearson correlation analysis it was observed that metacognitive awareness inventory (r = -0.191, p Conclusion: Obesity favouring factors and increased BP correlated strongly with diminished metacognition power, whereas daily breakfast eating had strong relationship with improved knowledge about cognition and comprehension skills. Keywords: Learning skills, Metacognition awareness inventory, Breakfast habits, Obesity, Blood pressure.
Efficacy of physical therapy interventions for chronic lateral elbow tendinopathy: a systematic review

Abstract Study Design: Systematic review. Background: Existing systematic reviews and meta-analyses do not support a specific physical therapy treatment for lateral elbow tendinopathy (LET). The results of these studies, however, may not accurately represent the current state of evidence. This may be due, in part, to methodological limitations in these studies, specifically the lack of utilization of standardized and disease-specific outcome measures. Objectives: To determine the effectiveness of physical therapy interventions in treating chronic lateral elbow tendinopathy as assessed in randomized controlled trials (RCTs) using pain-free grip strength and/or patient-rated tennis elbow evaluation questionnaire as outcome measures. Methods: A search of PubMed, Physiotherapy Evidence Database (PEDro), Scopus database, Google Scholar and bibliography was conducted from inception to November 2018. The methodological quality of the identified RCTs were assessed using the PEDro scale and the modified Sackett scale was used to appraise findings based on the level of evidence. Results: A total of two thousand nine hundred and six citations were identified, however, only twenty-two RCTs matched the eligibility criteria and were included in the review. The identified studies varied in design, investigated diverse physical therapy modalities that were applied for dissimilar periods, assessed outcome measures at unalike periods, and showed inconsistent results. Conclusion: A rigorous review of literature showed insufficient evidence to support or refute the effectiveness of many of the current physical therapy interventions for chronic LET. Nevertheless, the results might suggest immediate efficacy of mobilization with movement of the elbow joint and short-term efficacy of myofascial release technique. Level of evidence: Therapy, level 1a-
Das Bielefelder Profil Forschenden Lernens im Fachgebiet Deutsch als Zweitsprache

Seit einigen Jahren nimmt das Forschende Lernen als hochschuldidaktisches Prinzip in der Diskussion um die Professionalisierung von angehenden Lehrkraften einen zentralen Stellenwert ein. Der Beitrag beschaftigt sich mit der spezifischen Ausgestaltung Forschenden Lernens im Fachgebiet Deutsch als Zweitsprache am Universitatsstandort Bielefeld. Fokussiert werden insbesondere die fachspezifischen Voraussetzungen in Abgrenzung zu anderen an der Lehramtsausbildung beteiligten Fachern, die theoretische Verortung im Rahmen des soziokulturellen Paradigmas (u.a. Vygotskij, 2002/1934) sowie die theoretische Fundierung im pragmatistischen Forschungsbegriff nach Dewey (u.a. Dewey, 1991/1938). Des Weiteren werden didaktische Umsetzungen Forschenden Lernens im Rahmen des Moduls Deutsch als Zweitsprache in ihren Moglichkeiten und Grenzen diskutiert.
The dynamics of chromatin states mediated by epigenetic modifications during somatic cell reprogramming

Somatic cell reprogramming (SCR) is the conversion of differentiated somatic cells into totipotent or pluripotent cells through a variety of methods. Somatic cell reprogramming also provides a platform to investigate the role of chromatin-based factors in establishing and maintaining totipotency or pluripotency, since high expression of totipotency- or pluripotency-related genes usually require an active chromatin state. Several studies in plants or mammals have recently shed light on the molecular mechanisms by which epigenetic modifications regulate the expression of totipotency or pluripotency genes by altering their chromatin states. In this review, we present a comprehensive overview of the dynamic changes in epigenetic modifications and chromatin states during reprogramming from somatic cells to totipotent or pluripotent cells. In addition, we illustrate the potential role of DNA methylation, histone modifications, histone variants, and chromatin remodeling during somatic cell reprogramming, which will pave the way to developing reliable strategies for efficient cellular reprogramming.
Creando una cultura universitaria: How an educational technology non-profit organization engages families of elementary aged future first-generation Latin@ college students

This study explored the experiences of five mothers of future first-generation Latin@ college students in the first grade in a San Antonio area school that participated in the Yes! Our Kids Can® program. The purpose of this study was to learn how the parents or caregivers used technology to engage with the curriculum to help them create a college going culture at home. For this study, only mothers responded to the participant recruitment post with an interest to participate. This study used a qualitative narrative research method, specifically testimonio, and was guided by the learner centric ecology of resources framework along with community cultural wealth to listen to the voces to understand and make sense of the parents’ or caregivers’ experiences about if and how the messages they received from Yes! may influence them in the creation of a college going culture at home. By listening to the voces and testimonios of the caregivers themselves, we will be able to better support and increase the engagement, achievement rates, and success of future first-generation Latin@ college students. Five mothers volunteered to participate and share their testimonio during three individual interviews. The study uncovered the four temas or themes that follow: mothers engage with the Yes! curriculum on their smart phones, engage with it as an entire family, use it to create hope for a better future and to leverage their cultural capital to create a college going culture. The findings of this study confirm that a partnership between an elementary school and an EdTech non-profit organization is engaging participating mothers in their children’s education. It is imperative to redefine family engagement in order to create a college going culture in homes with future firstgeneration Latin@ college students.
Association Between Serum Bilirubin and the Progression of Carotid Atherosclerosis in Type 2 Diabetes

Objective This study investigated whether serum bilirubin levels can predict the progression of carotid atherosclerosis in individuals with type 2 diabetes mellitus (T2DM). Methods This observational study included 1,381 subjects with T2DM in whom serial measurements of carotid intima-media thickness (CIMT) were made at 1- to 2-year intervals for 6–8 years. The progression of carotid atherosclerosis was defined as newly detected plaque lesions on repeat ultrasonography. After dividing total serum bilirubin levels into tertiles, the association between total serum bilirubin at baseline and plaque progression status was analyzed. Results Among 1,381 T2DM patients, 599 (43.4%) were categorized as having plaque progression in their carotid arteries. Those with plaque progression were significantly older; showed a higher prevalence of hypertension, abdominal obesity, and chronic kidney disease; and had a longer duration of T2DM, higher levels of total cholesterol (TC), triglycerides, and insulin resistance, and lower total bilirubin concentrations than those with no plaque progression. When total serum bilirubin levels were divided into tertiles, the highest tertile group was younger than the lowest tertile group, with higher levels of TC and high-density lipoprotein cholesterol. Multiple logistic regression analysis demonstrated that higher serum bilirubin levels were associated with a significantly lower risk of CIMT progression (odds ratio, 0.584; 95% confidence interval, 0.392–0.870; p=0.008). Age (p<0.001), body mass index (p=0.023), and TC (p=0.019) were also associated with the progression of carotid atherosclerosis in T2DM patients. Conclusion Total serum bilirubin is independently associated with progression of atherosclerosis in the carotid arteries in T2DM patients.
Revitalizing Ultrasonic Positioning Systems for Ultrasound-Incapable Smart Devices

An ultrasonic positioning system (UPS) has demonstrated its high accuracy for years. However, few of the developed solutions have been deployed in practice to satisfy the localization demand of today’s smart devices, which lack ultrasonic sensors and were considered as being “deaf” to ultrasound. A recent finding demonstrates that ultrasound may be audible to the smart devices under certain conditions due to their microphone’s nonlinearity. Inspired by this insight, this work revisits the ultrasonic positioning technique and builds a practical UPS, called UPS+, for ultrasound-incapable smart devices. The core concept is to deploy two types of indoor beacon devices, which will advertise ultrasonic beacons at two different ultrasonic frequencies respectively. Their superimposed beacons are downconverted to a low-frequency by exploiting the nonlinearity effect at the receiver’s microphone. This underlying property functions as an implicit ultrasonic downconverter without inflicting harm to the hearing system of humans. We demonstrate UPS+, a fully functional UPS prototype, with centimeter-level localization accuracy using custom-made beacon hardware and well-designed algorithms.
Artificial intelligence technology for myopia challenges: A review

Myopia is a significant global health concern and affects human visual function, resulting in blurred vision at a distance. There are still many unsolved challenges in this field that require the help of new technologies. Currently, artificial intelligence (AI) technology is dominating medical image and data analysis and has been introduced to address challenges in the clinical practice of many ocular diseases. AI research in myopia is still in its early stages. Understanding the strengths and limitations of each AI method in specific tasks of myopia could be of great value and might help us to choose appropriate approaches for different tasks. This article reviews and elaborates on the technical details of AI methods applied for myopia risk prediction, screening and diagnosis, pathogenesis, and treatment.
Towards Adaptive Multipath Managing: A Lightweight Path Management Mechanism to Aid Multihomed Mobile Computing Devices

With the large scale deployment of multihomed mobile computing devices in today’s Internet, the Multipath TCP (MPTCP) is being considered as a preferred data transmission technology in the future Internet due to its promising features of bandwidth aggregation and multipath transmission. However, MPTCP is more likely to be vulnerable to the transmission quality differences of multiple paths, which cause a “hot-potato” out-of-order arrival of packets at the receiver side, and in the absence of a related approach to fix this issue, serious application level performance degradations will occur. In this paper, we proposes MPTCP-LM 3 , a Lightweight path Management Mechanism to aid Multihomed MPTCP based mobile computing devices towards efficient multipath data transmission. The goals of MPTCP-LM 3 are: (i) to offer MPTCP a promising path management mechanism, (ii) to reduce out-of-order data reception and protect against receiver buffer blocking, and (iii) to increase the throughput of mobile computing devices in a multihomed wireless environment. Simulations show that MPTCP-LM 3 outperforms the current MPTCP schemes in terms of performance and quality of service.
Marked differences of fat taste sensitivity between obese and lean subjects

Obesity is a risk factor for several diseases such as diabetes and cardiovascular complications. It is established that there is a difference of taste perception between lean and obese subjects. We used alternative forced-choice method to evaluate linoleic acid (LA) sensitivity in 58 West African subjects. LA sensitivity is inversely correlated with the body mass index and the waist circumference, and obesity biomarkers are higher as body mass index (BMI) increase. Our work suggests differences of fat taste sensitivity between BMI categories. Moreover, waist circumference was positively correlated with reduced fat taste sensitivity. Keys words: Obesity, body mass index (BMI), fatty acid sensitivity.
SAĞLIK HARCAMALARI İKTİSADİ BÜYÜME İLİŞKİSİ: OECD ÜLKELERİ ÜZERİNE BİR İNCELEME

Bu calismanin amaci, 36 OECD ulkesinin 2000-2017 donemine iliskin verilerini kullanarak panel koentegrasyon testleri yardimi ile saglik harcamalari ve iktisadi buyume arasindaki iliskiyi arastirmaktir. Elde edilen sonuclara gore, yatay kesit bagimliligini goz ardi eden Pedroni ve Westerlund testleri, saglik harcamalari ile buyume arasinda uzun donemli bir iliskinin mevcut oldugunu gostermektedir. Ancak yatay kesit bagimliligi goz onune alinarak elde edilen sonuclar, saglik harcamalari ve buyume arasinda uzun donemli bir koentegrasyon iliskisinin mevcut olduguna iliskin sonuclari desteklememektedir. Sonuc olarak uzun donemde saglik harcamalarinin, buyumenin bir belirleyicisi olmadigina iliskin bulgulara ulasilmistir.
LA MODELACIÓN DE LA HABILIDAD DIAGNÓSTICO PATOLÓGICO DESDE EL ENFOQUE HISTÓRICO CULTURAL PARA LA ASIGNATURA PATOLOGÍA VETERINARIA. THE MODELACIÓN OF THE ABILITY PATHOLOGICAL DIAGNOSIS FROM THE CULTURAL HISTORICAL FOCUS FOR THE SUBJECT VETERINARY PATHOLOGY.

The development of abilities is a topic of singular importance for those applied sciences of more level of specificity that lack an own and systematized didactics, as well as of a structuring of the fundamental abilities that they should develop in its students, socially reconciled, like it happens in the case of the Veterinary Pathology, in the Veterinary Doctor's formation. In this paper the theoretical conceptions used in the investigation are explained and the results reached in the modelation of the pathological Diagnosis ability are synthesized following a Cultural Historical Approach for the Veterinary Pathology.