Miracle-dz/UniFAR-FTUs huggingface dataset:
Yeast Culture and Vitamin E Supplementation Alleviates Heat Stress in Dairy Goats

This study was conducted to determine and compare the effects of yeast yeast culture (YC) and vitamin E (VE) supplementation on endotoxin absorption and antioxidant status in lactating dairy goats suffering from heat stress (HS). Three first lactation Saanen dairy goats (body weight 30±1.5 kg) were surgically fitted with indwelling catheters in the portal vein, mesenteric vein and carotid artery, and were randomly assigned to a 3×3 Latin square design. Dietary treatments were the basal diet, and the basal diet supplemented with either 100 IU VE or 30 g YC. Goats were kept in temperature and humidity-controlled room at 35°C from 8:00 to 20:00 and at 24°C from 20:00 till the next morning at 8:00. The relative humidity was kept at 55%. HS increased dairy goats’ rectum temperature and respiration frequency (p<0.01). HS reduced plasma flux rate of milk goats (p<0.01), but the plasma flux rate increased when the animal was under the conditions of the thermo-neutral period (p<0.01). The VE supplementation lowered dairy goats’ rectum temperature during thermo-neutral period (p<0.01). Meanwhile, no significant differences were observed between the control and YC treatment in rectum temperature and respiration frequency (p>0.05). Dietary supplementation of VE and YC reduced heat stressed dairy goats’ endotoxin concentration of the carotid artery and portal vein (p<0.01). However, the endotoxin concentration of the YC treatment was higher than that of the VE treatment (p<0.01). Both VE and YC supplementation decreased heat stressed dairy goats’ absorption of endotoxin in portal vein (p<0.01). The endotoxin absorption of YC treatment was higher than the VE treatment (p<0.01). The addition of VE and YC decreased dairy goats’ superoxide dismutase (SOD) concentration during HS and the whole experiment period (p<0.01). The addition of VE lowered SOD concentration during thermo-neutral period (p<0.01). Likewise, the addition of VE and YC lowered dairy goats’ malonaldehyde (MDA) concentration during HS and the whole experimental period, and the MDA concentration in the VE treatment was lower than the YC treatment (p<0.05). The addition of VE decreased MDA concentration during thermo-neutral period. On the contrast, the addition of VE increased dairy goats total antioxidant potential (TAP) concentration during HS, thermo-neutral and the whole experimental period (p<0.01). The addition of YC increased TAP concentration only during HS period (p<0.01). It is concluded that both VE and YC are useful in alleviating HS of dairy goats by weakening endotoxin absorption and promoting antioxidant capacity. Compared with YC, VE is much more powerful in easing dairy goats HS.
Equation of state for dense nucleon matter.

We report microscopic calculations of the equation of state for dense nuclear and neutron matter. The calculations are performed for five Hamiltonians: the Argonne ${v}_{14}$ and Urbana ${v}_{14}$ two-nucleon potentials, both alone and with the Urbana VII three-nucleon potential, and the density-dependent Urbana ${v}_{14}$ plus three-nucleon interaction model of Lagaris, Friedman, and Pandharipande. The beta-stable equation of state and neutron star structure are also calculated for three of the models. The models with the three-nucleon potential bracket the density-dependent model and are significantly stiffer than those with an unmodified two-nucleon potential only. The Argonne ${v}_{14}$ plus Urbana VII Hamiltonian produces a softening in the neutron matter equation of state localized around twice nuclear matter density which may indicate a neutral pion condensate.
Supplemental effects of probiotic Bacillus subtilis fmbJ on growth performance, antioxidant capacity, and meat quality of broiler chickens

&NA; This study aimed to investigate the supplemental effects of probiotic Bacillus subtilis fmbJ (BS fmbJ) on growth performance, antioxidant capacity, and meat quality of broiler chickens. A total of 240 day‐old male Arbor Acres (AA) broiler chickens were randomly allotted to 4 treatments and raised for 6 wk. Each treatment had 6 replicate pens with ten birds per replicate. Birds in the control group (CON) were fed diets without BS fmbJ and antibiotics. The BS groups were fed the basal diets with BS fmbJ at 2 × 1010 cfu/kg (BS‐1 group), BS fmbJ at 3 × 1010 cfu/kg (BS‐2 group), BS fmbJ at 4 × 1010 cfu/kg (BS‐3 group) without antibiotics for 42 d. In the study, dietary supplementation with BS fmbJ significantly improved (P < 0.05) the average daily gain (ADG), average daily feed intake (ADFI), and feed conversion ratio (FCR) of broilers from 21 to 42 d and 1 to 42 d. At 42 d, the final body weight was increased (P < 0.05) in BS‐2 group compared with that in CON. Dietary BS fmbJ significantly increased (P < 0.05) serum IgA and IgG concentrations of broilers after 42 days raising. The glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GSH‐Px), and superoxide dismutase (SOD) activity of serum and liver were increased (P < 0.05), and methane dicarboxylic aldehyde (MDA) contents in serum and liver were decreased (P < 0.05) by BS fmbJ added into the broiler diets. Dietary supplementation with BS fmbJ significantly decreased (P < 0.05) reactive oxygen species (ROS) contents in liver mitochondria of broilers. Additionally, the expression of antioxidant enzyme gene including nuclear factor erythroid 2‐related factor 2 (Nrf2), heme oxygenase 1 (HO‐1), superoxide dismutase (SOD), and glutathione peroxidase (GPx) were improved (P < 0.05) by BS fmbJ added into the broiler diets. Among measuring items of chicken breast meat quality, the drip loss, cooking loss, shear force, L*24 h, a*24 h, b*45 min, and b*24 h values were influenced (P < 0.05) by BS fmbJ provided in the diet. Based on these results, Bacillus subtilis fmbJ could be acted as a beneficial feed additive with antioxidant capacity in broiler diets.
The implementation of a novel P2P service re-directing mechanism in optical passive networks

Toward the P2P topology mismatch problem, we proposed a novel P2P service re-directing scheme and it is fully described in reference[1]. Furthermore, we have successfully implemented this mechanism in EPON system. Experimental results show that our scheme can effectively reduce core network traffic, and evidently improve clients' downloading rate.
Daytime Fluctuation of Intraocular Pressure in Patients With Primary Angle-Closure Glaucoma After Trabeculectomy

Purpose:To evaluate the daytime fluctuation of intraocular pressure (IOP) in patients with primary angle-closure glaucoma (PACG) after trabeculectomy. Participants and Methods:A total of 176 patients with PACG participated in a clinical trial of trabeculectomy with or without releasable sutures. Applanation IOP was measured at 5, 7, and 10 AM, and 2, 6, and 10 PM at 3 months posttrabeculectomy. We documented the mean, peak, and trough IOPs, determined the fluctuation of daytime IOP, and explored the associations of IOP fluctuation with baseline factors. Results:IOP measurements were obtained in 173 patients. The mean daytime IOP was 13.2±3.7 mm Hg; mean peak IOP 15.1±4.1 mm Hg, mean trough IOP 11.3±3.5 mm Hg, and mean fluctuation 3.8±2.1 mm Hg. Fluctuation was positively correlated with peak (r=0.528, R2=0.28, P<0.001) and mean IOP (r=0.278, R2=0.08, P<0.001), but not with the trough IOP (r=0.015, P=0.843). Fluctuation was lower with extent of bleb (0.6 mm Hg/unit increase in extent; 95% CI, 0.1-1.2 mm Hg) and in blebs with microcysts (1.1 mm Hg less fluctuation; 95% CI, 0.2-1.9 mm Hg). Fluctuation was not associated with sex, age, baseline IOP, extent of peripheral anterior synechia or number of glaucoma medications before surgery, mean deviation of the visual field, vertical cup:disc ratio, or the use of releasable sutures. Conclusions:The mean fluctuation of daytime IOP after trabeculectomy for PACG was about 4 mm Hg. The fluctuation was positively associated with higher peak and mean IOP and negatively associated with extent of bleb and presence of microcysts.
Tibial Plateau Fracture Repairs Augmented With Calcium Phosphate Cement Have Higher In Situ Fatigue Strength Than Those With Autograft

Objectives: This study compared the biomechanical fatigue strength of calcium phosphate augmented repairs versus autogenous bone graft (ABG) repairs in lateral tibia plateau fractures. Methods: Eight matched pairs of tibias (six male, two female; age, 75 ± 14 years) were harvested from fresh-frozen cadavers. Reproducible split-depression fractures were simulated and repaired by an orthopaedic traumatologist using a lateral tibial plateau plate. One tibia from each donor was randomly assigned to either calcium phosphate (Callos; Acumed, Hillsboro, OR) or ABG as augmentation. The femoral component of a hemitotal knee arthroplasty was attached to the actuator of a servohydraulic press and centered above the repair site. Cyclic, physiological compression loads were applied at 4Hz starting with a maximum load of 15% body weight and increasing by 15% body weight every 70,000 cycles. Loading conditions were determined from calculations of weight distribution, joint contact area, and gait characterization from existing literature. Repair site depression and stiffness were measured at regular intervals. Specimens were then loaded to failure at 1 mm/min. Results: Calcium phosphate augmented repairs subsided less and were more stiff during the fatigue loading than were ABG repairs at the 70,000, 140,000, and 210,000 cycle intervals (P < 0.03) All repairs survived to 210,000 cycles. The average ultimate load of the calcium phosphate repairs was 2241 ± 455 N (N = 6) and 1717 ± 508 N (N = 8) for ABG repairs (P = 0.02). Conclusion: Calcium phosphate repairs have significantly higher fatigue strength and ultimate load than ABG repairs and may increase the immediate weightbearing capabilities of the repaired knee.
Pink noise generation using wavelets

Pink noise appears in many research fields requiring both estimation and synthesis. Its analysis is difficult due to the non stationary nature of pink noise. We propose a method based on wavelets to transform the pink noise into a stationary random process whose ingredients let us to derive a pink noise like processes generation method. We highlight by simulations the performance of the proposed pink like noise generation method.
Multiple Actions of Phencyclidine and (+)MK-801 on Isolated Bovine Cerebral Arteries

This study examines the direct effects of 3 noncompetitive N-methyl-D-aspartate receptor antagonists, phencyclidine (PCP), (+)MK-801, and (−)MK-801, on bovine middle cerebral arteries (BMCA). Rings of BMCA were mounted in isolated tissue chambers equipped with isometric tension transducers to obtain pharmacologic dose-response curves. In the absence of endogenous vasoconstrictors, the 3 N-methyl-D-aspartate antagonists each produced direct constriction of BMCA. The thromboxane A2 receptor antagonist SQ-29,548, the TxA2 synthase inhibitor furegrelate, the calcium antagonist nimodipine, and calcium-deficient media all inhibited maximal phencyclidine or (+)MK-801-induced constriction. Direct constriction by PCP or (+)MK-801 was independent of the presence of endothelium. When BMCA were preconstricted with potassium-depolarizing solution, PCP, (+)MK-801, and (−)MK-801 each produced only concentration-dependent relaxation. When BMCA were preconstricted with the stable TxA2 analog U-46,619 and exposed to increasing concentrations of PCP, (+)MK-801, or (−)MK-801, tension increased. Thromboxane A2 may contract BMCA by acting as a potassium channel blocker; iberiotoxin and tetraethylammonium both constrict BMCA. In Ca2+-deficient media containing either potassium or U-46,619, phencyclidine and (+)MK-801 each produced competitive inhibition of subsequent Ca2+-induced constriction. In additional experiments, arterial strips were mounted in isolated tissue chambers to directly measure calcium uptake, using 45Calcium as a radioactive tracer. Both phencyclidine and (+)MK-801 blocked potassium-stimulated or U-46,619-stimulated 45Ca uptake into arterial strips. These results suggest that phencyclidine and (+)MK-801 have 2 separate actions on BMCA. They may constrict arterial rings by releasing TxA2 from cerebrovascular smooth muscle, and relax arterial rings by acting as calcium antagonists.
Engineering Large-Scale Body Area Networks Applications

This paper presents an approach to design and deploy large-scale applications for body area networks (BANs). The approach is based on BodyCloud, which is a Cloud-based multi-tier application-level architecture. BodyCloud integrates a Cloud computing platform and the SPINE BAN middleware. It specifically provides programming abstractions, such as group, modality, workflow and view, which support the rapid and effective development of community BAN applications. This work provides an overview of the general architecture of BodyCloud and discusses several large-scale application services that can be deployed on BodyCloud.
Cytoskeletal Rearrangements and Transcriptional Activation of c-fos Serum Response Element by Rho-kinase*

The small GTPase Rho is implicated in cytoskeletal rearrangements including stress fiber and focal adhesion formation and in the transcriptional activation of c-fosserum response element. In vitro, Rho-kinase, which is activated by Rho, phosphorylates not only myosin light chain (MLC) (thereby activating myosin ATPase) but also myosin phosphatase, thus inactivating myosin phosphatase. Rho-kinase is involved in the formation of stress fibers and focal adhesions in fibroblasts. Here we show that the expression of constitutively active Rho-kinase increased the level of MLC phosphorylation. The activity of Rho-kinase was necessary for maintaining the vinculin-containing focal adhesions, whereas organized actin stress fibers were not necessary for this. The microinjection of constitutively active Rho-kinase into fibroblasts induced the formation of focal adhesions to some extent under the conditions where organized actin stress fibers were disrupted. The expression of constitutively active Rho-kinase also stimulated the transcriptional activity of c-fos serum response element. These results suggest that Rho-kinase has distinct roles in divergent pathways downstream of Rho, which include MLC phosphorylation leading to stress fiber formation, focal adhesion formation, and gene expression.
Does perceived risk influence the effects of message framing? Revisiting the link between prospect theory and message framing

ABSTRACT Health-promoting messages can be framed in terms of the beneficial consequences of healthy behaviour (gain-framed messages) or the detrimental consequences of unhealthy behaviour (loss-framed messages). An influential notion holds that the perceived risk associated with the recommended behaviour determines the relative persuasiveness of gain- and loss-framed messages. This ‘risk-framing hypothesis’, which was derived from prospect theory, has been central to health message-framing research for the better part of two decades and has enduring appeal to researchers and practitioners. It has found its way into several health communication handbooks and is communicated to the general public. The present article examines the validity of the risk-framing hypothesis anew by providing a review of the health message-framing literature. In spite of its ongoing appeal, we conclude that the hypothesis has severe theoretical flaws. In addition, we find that the empirical evidence in favour of the hypothesis is weak and inconsistent. It seems that, in applying prospect theory’s tenets to a health-promotion context, some of the theory’s key aspects have been lost in translation. At the close of the article, we offer a research agenda for the future, arguing that, above all, new methodology is needed to bring the message-framing literature further.
The impact of a suspicious prostate biopsy on patients’ psychological, socio-behavioral, and medical care outcomes

AbstractOBJECTIVE: To evaluate the psychological, socio-behavioral, and medical implications of apparently false-positive prostate cancer screening results. METHODS: One hundred and twenty-one men with a benign prostate biopsy performed in response to a suspicious screening test (biopsy group) and 164 men with a normal prostate-specific antigen (PSA) test result (normal PSA group) responded to a questionnaire 6 weeks, 6 and 12 months after their biopsy or PSA test. RESULTS: The mean (±SD) age of respondents was 61±9 years (range, 41 to 88 years). One year later, 26% (32/121) of men in the biopsy group reported having worried “a lot” or “some of the time” that they may develop prostate cancer, compared with 6% (10/164) in the normal PSA group (P<.001). Forty-six percent of the biopsy group reported thinking their wife or significant other was concerned about prostate cancer, versus 14% in the normal PSA group (P<.001). Medical record review showed that biopsied men were more likely than those in the normal PSA group to have had at least 1 follow-up PSA test over the year (73% vs 42%, P<.001), more likely to have had another biopsy (15% vs 1%, P<.001), and more likely to have visited a urologist (71% vs 13%, P<.001). CONCLUSION: One year later, men who underwent prostate biopsy more often reported worrying about prostate cancer. In addition, there were related psychological, socio-behavioral, and medical care implications. These hidden tolls associated with screening should be considered in the discussion about the benefits and risks of prostate cancer screening.
Glitch Game Testers: African American Men Breaking Open the Console

Glitch Game Testers is a research project to develop a sustainable high school job program to train and employ high school students as game testers [1]. Our goal is to leverage the passion that young urban African American men have for video games into agency with technology. The first step is to encourage these young people to see the computation behind digital games and the second step is to offer a contextualized computing curriculum [2]. In this paper, we will present findings from formative work on the play practices of young African American men, introduce the Glitch Game Testers project, and report on preliminary findings from workshops. By looking at the intersection of race and gender in gaming practices, we have developed Glitch to specifically meet the cultural needs for young African American men.
Ghrelin Inhibits Proinflammatory Responses and Prevents Cognitive Impairment in Septic Rats

Objectives: A novel stomach-derived peptide, ghrelin, is down-regulated in sepsis and its IV administration decreases proinflammatory cytokines and mitigates organ injury. In this study, we wanted to investigate the effects of ghrelin on proinflammatory responses and cognitive impairment in septic rats. Design: Prospective, randomized, controlled experiment. Setting: Animal basic science laboratory. Subjects: Sprague-Dawley rats, weighing 250–300 g. Interventions: Sepsis was induced by cecal ligation and puncture. Animals were randomly divided into four groups: sham, sham + ghrelin, cecal ligation and puncture, and cecal ligation and puncture + ghrelin. Saline was given subcutaneously (30 mL/kg) at 4 and 16 hours after surgery for all rats. Septic rats were treated with ceftriaxone (30 mg/kg) and clindamycin (25 mg/kg) subcutaneously at 4 and 16 hours after surgery. Ghrelin (80 &mgr;g/kg) was administrated intraperitoneally 4 and 16 hours after surgery in sham + ghrelin group and cecal ligation and puncture + ghrelin group. Measurements and Main Results: The levels of proinflammatory cytokines in hippocampus were measured by enzyme-linked immunosorbent assay, and cleaved caspase-3 was detected by Western blot 24 hours after surgery. Neuronal apoptosis was determined by terminal deoxynucleotidyl transferase dUTP nick-end labeling staining 48 hours after surgery. Additional animals were monitored to record survival and body weight changes for 10 days after surgery. Survival animals underwent behavioral tasks 10 days after surgery: open-field, novel object recognition, and continuous multiple-trial step-down inhibitory avoidance task. Ghrelin significantly decreased the levels of proinflammatory cytokines and inhibited the activation of caspase-3 in the hippocampus after cecal ligation and puncture. The density of terminal deoxynucleotidyl transferase dUTP nick-end labeling–positive apoptotic neurons was significantly lowered by ghrelin. In addition, ghrelin improved the survival rates after cecal ligation and puncture. There were no differences in the distance and move time between groups in open-field task. However, the survivors after cecal ligation and puncture were unable to recognize the novel object and required more training trials to reach the acquisition criterion. All these long-term impairments were prevented by ghrelin. Conclusions: Ghrelin inhibited proinflammatory responses, improved the survival rate, and prevented cognitive impairment in septic rats.
The effect of Zymosan on the phagocytosis of foreign erythrocytes.

The disappearance of sheep erythrocytes in the rat and in the rabbit has been shown to be a rapid exponential function attributable to phagocytosis. Following this initial erythrophagocytosis hemoglobin is released back into the circulation, reflecting the catabolic function of the reticuloendothelial system. Zymosan causes an increased rate of removal of erythrocytes but does not alter the disappearance rate of foreign albumin. The relationship of phagocytosis to antibody production and the fact that enhanced antibody formation in Zymosan-treated animals cannot be attributed to more efficient phagocytosis are discussed.
Food insecurity in Australia: Implications for general practitioners.

BACKGROUND In Australia, it would appear that food is abundant. For a proportion of people, however, accessing enough food to eat can be a daily or weekly struggle. OBJECTIVE This article provides a summary about the prevalence, causes and consequences of food insecurity that affects vulnerable populations in Australia, and discusses the implications for general practitioners (GPs). DISCUSSION It is estimated that 4% of Australians cannot access sufficient, safe and nutritious food. Food insecurity can be both a precursor to, and a by-product of, chronic disease and poverty. Patients who are food insecure may skip meals, eat cheap food and experience stress. They may show incredible resilience and skills in managing and masking this issue. Identifying this vulnerable population is of high importance to GPs as it has an impact on the work-up and care of such individuals. Effective links between welfare and health services are required to address patients' material, financial and environmental barriers to food security.