Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative Clinical study of Jatyadi Taila and Jatyadi Ghrita in the management of Dushta Vrana

Dushta Vrana is a common and frequently encountered problem faced in surgical practice. The presence of Dushta Vrana worsens the condition of the patient with different complications and may become fatal. Local factors on wound like slough, infection and foreign body, affect the normal process of healing. A healthy wound in a normal body heals earlier with a minimum scar as compared to a contaminated wound. Therefore in this study all the efforts are made to make a Dushta Vrana into a Shuddha Vrana. Once the Vrana becomes Shuddha, Ropana of the Vrana will start. The objective of the study was to evaluate the clinical efficacy of Jatyadi Taila and Jatyadi Ghrita in Dushta Vrana. Clinically diagnosed 60 Patients of Dushta Vrana were randomly divided into two groups, each consisting of 30 Patients. Group A were treated with the Jatyadi Taila and Group B was treated by Jatyadi Ghrita. The results observed was based on the relief obtained on the subjective and objective parameters taken for consideration for this study viz, size of ulcer, discharge, smell, pain, burning sensation, itching and granulation were found significant (P Lass Than 0.05). On the basis of assessment criteria and overall result of treatment, the patients of Jatyadi Taila group showed better results when compared to Jatyadi Ghrita group. Even though statistically there is no much significant difference between the two groups, but by seeing the effect on individual parameters (subjective and objective) and over all response, Jatyadi Taila seems to be effective when compared to Jatyadi Ghrita. It is having more Ropana qualities when compared to Shodhana.
Breast Ultrasound Computer-Aided Diagnosis: Analysis of Types of Errors

Breast cancer is the most common malignancy in women and the second leading cause of mortality worldwide (1). In Republic of Korea, breast cancer is the second most common malignancy and fifth leading cause of mortality in women (2). It is important to detect cancer early to reduce the mortality rate, and this requires an accurate and reliable diagnostic method. In clinical practice, breast ultrasound (US) is an important modality for detecting breast cancer, along with mammography (3). Compared with mammography, breast US is an easily available imaging tool that does not involve a radiation hazard. However, operator dependency remains the main limitation (4). From that perspective, computer-aided diagnosis (CAD) systems in breast US have been developed for lesions and can characterize and improve the differentiation between benign and malignant lesions. Many studies have applied CAD systems to breast US to demonstrate the efficiency of CAD systems and to evaluate the usefulness of CAD systems for improving diagnostic accuracy (4-11). There are two algorithms in breast USCAD systems for lesion interpretations. One is the interpretation according to the breast imaging reporting and data system (BI-RADS) lexicon, which is known as the knowledge-based analysis, and the other is the deep-learning algorithm, which is known as statistics-based analysis. S-Detect is a recently developed CAD system for breast US Breast Ultrasound Computer-Aided Diagnosis: Analysis of Types of Errors 유방 초음파 컴퓨터 진단: 오류 유형 분석
Re: Parkes Weber syndrome: a case of right lower limb hypertrophy

should be: ‘there was no difference in analgesic outcomes identified between the two groups’ instead of ‘equivalent analgesic outcomes’. Dr Kendall also expresses concern regarding ‘underpowering’ based on the results in table 3. All the results presented in table 3 (including opioid consumption) were secondary outcomes. As randomized clinical trials are powered based on the primary outcome, this concern cannot be addressed. It is a common misconception that a trial is underpowered because there is no difference seen in secondary outcomes and this perception should be eradicated from the literature through increased education. Most of the blocks were placed under vision at conclusion of the surgery by the surgical team. We did not perform a comparison between surgical or anaesthetic placement due to the fact this was not a pre-specified outcome in the protocol. The authors felt that such a sub-group comparison, while potentially interesting, may lead to misleading results. Regardless we agree with Dr Kendall that it would be an interesting concept to put towards a trial on abdominal wall blockade: whether there is any difference between surgical and anaesthetic placement of the blocks. Our suspicion is that this would depend on the local expertise of individual units.
Successful treatment of atopic dermatitis with the JAK1 inhibitor oclacitinib

Abstract We report the first case of atopic dermatitis successfully treated with the oral Janus kinase-1 (JAK1) inhibitor oclacitinib. A man in his 70s, with a 6-year history of skin disease refractory to topical and biologic therapies, self-prescribed this veterinary medication with rapid remission of symptoms. He has remained in remission for 7 months with no reported adverse side effects or infections. JAK1 plays a central role in expression of proinflammatory cytokines IL-4, IL-5, and IL-13, which play an important role in the pathogenesis of atopic dermatitis. Ruxolitinib and tofacitinib are JAK inhibitors currently approved by the Food and Drug Administration for the treatment of myelofibrosis, rheumatoid arthritis, and psoriatic arthritis in humans. Oclacitinib is not currently indicated for use in humans.
Innovative Methods Of Studying Blood With Atomic Force Microscopy In Geriatrics

Objective: To study the morphological forms of erythrocytes, their pathomorphological changes in diseases of the cardiovascular system, as well as for oncological pathology in the organs of the urinary system with atomic force microscopy (AFM). Methods: The morphological properties of erythrocytes were studied by means of hemoscanning and erythrocytometry. AFM was produced by us in the probe laboratory Ntegra-Aura (Russia). The studies were performed in contact modes of intermittent or constant profiles using commercial Si or SiN cantilevers in conditions of low atmospheric vacuum. Processing and implementation of AFM images were formulated using the software "NOVA" and "ImageAnalysis". Results: It was shown that as the severity and intensity of chronic heart failure (CHF) increased, the altered forms of erythrocytes increased. We revealed an increase in the number of irregular forms of erythrocytes from the total number, the number of cells with the effect of "deflated ball", shadow cells, and the number of red blood cells involved in the processes of sludging. Patients with prostate cancer ( РС ) and kidney cancer (KC) had a decrease of discocytes in comparison with the control group and the group with benign prostatic hyperplasia (BPH) and an increase of transitional, prehemolitic and degenerative forms. There was no significant difference in the structure of erythrocytes in different age groups. Conclusions: As a result of the study it was established that in CHF and oncological processes a change in the cytoarchitectonics of erythrocytes is observed. Modified cells are partially functionally inferior and cannot fully fulfill their most important oxygen transport function. Key words: atomic force microscopy, erythrocytes, diseases of the cardiovascular system, oncology
Bone Changes and Carotid Atherosclerosis in Postmenopausal Women

Background and Purpose Because of increased life expectancy, most postmenopausal women today suffer from osteoporosis and atherosclerotic diseases, which are currently considered unrelated diseases. Our study was aimed at analyzing relations between bone mineral density (BMD) and ultrasonographic assessment of carotid wall characteristics. Methods The relation of carotid atherosclerosis to BMD was examined in 30 postmenopausal women aged 67 to 85 years. High-resolution B-mode ultrasonography was performed, and the severity of carotid atherosclerosis was determined by plaque score. BMD was measured by dual-energy x-ray absorptiometry. Results The correlation of plaque score with low total BMD was r=. 549 (P<.002). Multiple linear regression analysis indicated significant correlation of plaque score with total cholesterol level and low total BMD. Conclusions Our results suggest a relation between carotid atherosclerosis, one of the major causes of ischemic cerebrovascular diseases, and osteoporosis.
Nosocomial Burkholderia cepacia infection in a tertiary hospital; Five-year surveillance: A retrospective cross-sectional study

Amac: Burkholderia cepacia, glikozu fermente edemeyen aerobik, Gram-negatif ve cok ilaca direncli bir bakteridir. Immunsuprese hastalarda onemli bir firsatci bakteri olan Burkholderia cepacia, ciddi pulmoner enfeksiyonlara neden olur. Bu calismada, son bes yilda tespit edilen Burkholderia cepacia vakalarini degerlendirmeyi amacladik. Yontemler: Calisma retrospektif olarak planlandi. Calismaya 2013-2018 yillari arasinda ucuncu basamak hastanedeki 46 B. cepacia olgusu dahil edildi. Yas, cinsiyet, klinik oyku, alinan ornek tipi, hastalarin son durumu (yasiyor veya olu) ve hastanede yatis suresi kaydedildi. Bulgular: Orneklerin dagilimi incelendiginde, kan kulturunde %32,6 (n=15), idrar kulturunde %32,6 (n=15), trakeal aspiratta %17.4 (n=8) bulundu. Hastalarin son durumlari yasiyor veya olu olarak degerlendirildi. Buna gore, olgularin %65,2’sinin (n=30) yasadigi, %34,8’inin (n=16) ise oldugu tespit edildi. Olgularin kliniklere gore dagilimi incelendiginde, anestezi %19,6 ile (n=9) ilk siradaydi. Hastanede kalis suresi ortalama 24,6 ± 25,3 gundu (minimum-maksimum: 3-122 gun). Sonuc: Burkholderia cepacia onemli bir nozokomiyal firsatci enfeksiyondur ve siklikla cok ilaca direnclidir. Bu sebeple hastalik etkin bir sekilde tedavi edilmelidir aksi halde hastaligin mortalite ile sonuclanacagi unutulmamalidir.
Presentations of anxiety in older people

practice. Although it is less common in people aged 65 years or older than in younger age groups, it can be disabling for this older group, in whom it tends to present with somatic complaints and worry rather than as autonomic anxiety. Although anxiety developed as an evolutionary response to danger, excessive anxiety that causes functional impairment or significant distress is not a part of normal ageing. GPs have a vital role in the recognition and treatment of anxiety in this age group, in particular to prevent psychological and physical sequelae.
Coronary microcirculation dysfunction in patients with arterial hypertension

The number of articles regarding microcirculation dysfunction in the literature increases. One should bear them in mind especially in case of patients, who declare typical angina, and in whom during coronary angiography we do not reveal significant lesions in coronary arteries. Arterial hypertension is one of diseases, which may contribute to microcirculation dysfunction and vessels remodeling. In this short review, we discuss possible mechanism of abovementioned disturbances.
Effect of Pacing Chamber and Atrioventricular Delay on Acute Systolic Function of Paced Patients With Congestive Heart Failure

Background—Previous studies of pacing therapy for dilated congestive heart failure (CHF) have not established the relative importance of pacing site, AV delay, and patient heterogeneity on outcome. These variables were compared by a novel technique that evaluated immediate changes in hemodynamic function during brief periods of atrial-synchronous ventricular pacing. Methods and Results—Twenty-seven CHF patients with severe left ventricular (LV) systolic dysfunction and LV conduction disorder were implanted with endocardial pacing leads in the right atrium and right ventricle (RV) and an epicardial lead on the LV and instrumented with micromanometer catheters in the LV, aorta, and RV. Patients in normal sinus rhythm were stimulated in the RV, LV, or both ventricles simultaneously (BV) at preselected AV delays in a repeating 5-paced/15-nonpaced beat sequence. Maximum LV pressure derivative (LV+dP/dt) and aortic pulse pressure (PP) changed immediately at pacing onset, increasing at a patient-specific optimal.
The Impact of Serodiscordance on the Affective, Sexual and Reproductive Life of HIV Patients Presenting to Imo State University Teaching Hospital (IMSUTH) Orlu, Imo State Nigeria

Introduction: Human Immunodeficiency Virus (HIV) is a recognized health issue. As the virus continues to spread and neither a vaccine nor cure exists, its prevention remains the key strategy for curbing the pandemicity of the disease. Serodiscordance refers to people of different HIV serum antibody status, i.e., opposite serum antibody test results for couples or regular sexual partners. Serodiscordant relationships are faced with daily challenges that include but not limited to emotional, preventive health, self-disciple and preconception and reproductive issues. Understanding the effect of serodiscordance on the affect, sexual and reproductive life of affected couples will help develop patient care programs that improve their quality of life. Methods: The study design was cross-sectional to determine the impact of serodiscordance on the affective, sexual and reproductive life of HIV Serodiscordant couples living in Imo state Nigeria. Data collection was through a psychosocial questionnaire, focus groups, and individual interviews. The study was conducted at Imo State University Teaching Hospital (IMSUTH). It is situated in Umuna, a town in Orlu Local Government Area of Imo State. Results/Discussion: The required sample size was determined to be serology positive 278 participants. Among 84 patients who had HIV seronegative partners; 33 were male. Out of the 42 patients that used a condom, 39 had told their partners about their status. Fears, guilt feelings can arise, negatively impacting patient sexuality as our study ascertained that a total of 54 (64.3%) patients out of the 84 discordant couples feared that they would transmit the infection to their partner regardless of counseling on best practices to reduce horizontal transmission. Conclusions: Serodiscordance remains a significant contributor to the increased risk of horizontal transmission in sub-Saharan countries. Our study revealed that the impact of serodiscordance goes beyond the spread of disease. It impacts the affect, sexual and reproductive lives of affected couples leading to an overall decrease in patient quality of life. Lastly, future studies on this topic should be back with real-time laboratory screening tests, and couples should be encouraged to participate together to ensure transparency.
Is hiesho in pregnant women a risk factor for postpartum haemorrhage?

INTRODUCTION In Japanese culture, a cold sensation known as “hie” is an important symptom in traditional medicine. Hiesho is considered to be a condition in which the sympathetic nervous system becomes dominant, resulting in poor circulation in the extremities due to contraction of the peripheral blood vessels. In Nakamura, Ichisato, Horiuchi, Mori, and Momoi’s (2011) analysis of the concept of hiesho, it is defined as a condition in which “there is a difference between core temperature and peripheral temperature and a delay in the rise of the peripheral temperature even when the individual is in a warm environment, resulting in a ‘chilly feeling’ in many cases” (p.2).
Peroxisome Proliferator-Activated Receptor γ Activators Downregulate Angiotensin II Type 1 Receptor in Vascular Smooth Muscle Cells

Background—Peroxisome proliferator-activated receptor γ (PPARγ) activators, such as troglitazone (Tro), not only improve insulin resistance but also suppress the neointimal formation after balloon injury. However, the precise mechanisms have not been determined. Angiotensin II (Ang II) plays crucial roles in the pathogenesis of atherosclerosis, hypertension, and neointimal formation after angioplasty. We examined the effect of PPARγ activators on the expression of Ang II type 1 receptor (AT1-R) in cultured vascular smooth muscle cells (VSMCs). Methods and Results—AT1-R mRNA and AT1-R protein levels were determined by Northern blot analysis and radioligand binding assay, respectively. Natural PPARγ ligand 15-deoxy-Δ12,14-prostaglandin J2, as well as Tro, reduced the AT1-R mRNA expression and the AT1-R protein level. The PPARγ activators also reduced the calcium response of VSMCs to Ang II. PPARγ activators suppressed the AT1-R promoter activity measured by luciferase assay but did not affect the AT1-R mRNA.
Study of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) as a predictor inflammatory marker for diabetic nephropathy in type 2 diabetic patients

Background: Diabetes mellitus (DM) is a systemic disease having serious microvascular and macrovascular complications. DN in T2DM has an inflammatory pathology. Many inflammatory markers have been found to be related to DN, such as interleukin1 (IL1), IL6, IL8, transforming growth factor beta 1(TGF-β1) and tumor necrosis factor alpha (TNF α). However, their measurement is not used routinely as it is not easy to do it, in this respect. Search for inflammatory markers for the disease is a continuous process to enhance the diagnostic and treatment process. Aim of the Work: To assess neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) as a predictor inflammatory markers for diabetic nephropathy in type 2 diabetic patients. Patients and Methods: This study is a prospective one that was carried out on one hundred (100) type 2 Diabetes mellitus (T2DM) patients attending to internal medicine outpatient clinic and inpatient department of internal medicine at Al-Azhar university hospital, Damietta and twenty five (25) apparently healthy volunteers as a control. The populations of the study were classified into three groups according to their level of albuminuria. All were subjected tofull history and Clinical examination, Laboratory tests include Fasting mid-stream urine samples were obtained and examined for complete urine analysis and albumin/creatinine ratio (UACR),Complete blood count (CBC), HbA1c,Fasting blood sugar, Renal Function Tests,eGFR and Abdominal ultrasonography, Fundus examination and ECG and Assessment of NLR &PLR. Results: Our study showed that there was high statistically significant increased NLR, PLR and UACR in group IB when compared to group IA, II and III. Also there was statistically significant increased NLR,PLR and UACR in group IA in comparison to group II and also there was statistically significant increased NLR,PLR and UACR in group II in comparison to group III. Conclusion: Neutrophil lymphocyte ratio (NLR) & Platelet lymphocyte ratio (PLR) was significantly associated with diabetic nephropathy (DN) and high Neutrophil lymphocyte ratio (NLR) & Platelet lymphocyte ratio (PLR) values may be considered as a predictor and a prognostic risk markers of diabetic nephropathy (DN).
Dose painting en cáncer de próstata a través de imágenes simultáneas PET/MR C11-colina y multiparamétrico MR.

Las imagenes PET/MR con C11-Colina utilizadas actualmente para diagnostico de cancer de prostata en el Servicio de Medicina Nuclear de la Fundacion Escuela de Medicina Nuclear (FUESMEN) resultan de gran utilidad en la planificacion del tratamiento de RT para la identificacion de: lesiones tumorales, capsula prostatica y vesiculas seminales. El presente trabajo se enfoco en las bondades que ofrecen las imagenes PET/MR para identificar lesiones tumorales en prostata a partir del metabolismo del radiofarmaco C11-Colina y su correlacion con imagenes anatomicas de alta resolucion T2W y funcionales DWI lo cual permitio definir un nuevo volumen target en la planificacion del tratamiento de RT, denominado BTV (Biological Target Volumen). A partir de la definicion del nuevo volumen BTV a traves de las imagenes del protocolo Multiparametrico PET/MR se realizaron dos planificaciones basadas en dose painting implementando el concepto de boost integrado simultaneo (SIB: Simultaneous Integrated Boost). Para la planificacion se utilizaron las imagenes de tomografia adquiridas mediante simulacion virtual, mientras que las imagenes PET/MR fueron registradas y fusionadas, para una mejor identificacion de la lesion tumoral, permitiendo llevar a cabo los escalamientos de dosis planteados.
A Human-Centered Approach to Hazard Evaluation Checklists for the Risk of Back Pain in Manual Handling Tasks

Low back pain is one the most common medical problems in the U.S. In workplaces, manual handling tasks show strong evidence for low back pain. Hazard Evaluation Checklists are commonly used as a rapid ergonomic assessment to evaluate the risk of back pain in manual handling tasks. However, this tool focuses on only job-specific tasks instead of aiming to detect the possibility of having back pain in individuals. It was proposed that a human-centered checklist that assesses workers’ welfare in addition to the analysis of the worksite might predict low back pain risk in workers more accurately. In the current study, a case study was conducted to show the importance of focusing on workers’ welfare. In the ergonomic assessment of a coffee shop, it was found that the tasks of baristas were more likely to cause low back pain and wrist pain. The barista who was working in housekeeping, mopping floors, reported that she suffers from low back pain more than wrist pain. However, the barista who was playing guitar professionally reported wrist pain. These case study findings supported the claim that the risk of occurrence of low back pain might increase with the combination of work-related tasks and contributory factors. Thus, a human-centered checklist proposed including four sub-categories: the main manual handling tasks, a second job, non-work related activities, and personal risk factors. It was proposed that efforts to limit low back pain in society might be more successful with this human-centered approach.
The Effect of Flaxseed Extract on Skin Elasticity of The Healing Wound In Rabbits

Management of disturbed wounds, large skin defects and the areas where skin tension precludes wound closure is of high clinical importance. Healing in such wounds occurs through epithelization and contraction processes (second-intentions healing) that may result in certain undesirable complications including keloid formations, a poor final cosmetic appearance and the formation of a fragile epithelial layer. The objective of this study is to evaluate the effectiveness of flaxseed gel in enhancing connective tissue firmness and improving skin texture during wound healing by means of viscoelasticity parameter. 30-male white neozealand rabbit were included in this study divided into 3 groups; one group of 10 rabbit received Flax seed gel topically for three times intervals (1, 3, and 7 days); a second group received Fucidin cream as positive control, while third group have not received any treatment as negative control, Skin elasticity measurements were performed using the DermaLab system (Cortex Technology). Photos of treated areas were taken during the procedure. Throughout the study skin elasticity was significantly greater in the Flaxseed group than in other groups. Flaxseed increase elasticity value from (4.2±1.02) to (4.7±1.9) after 7 days treatment ( P=0.003 ). while no significant differences were evident in both Fucidin treated group (positive) control (1.0±0.34) and non-treated group (negative) control (1.8±1.4) (p=0.068) group. Hence, Young's modulus of skin elasticity in flaxseed group was more reproducible than other groups demonstrating the comparable efficacy of flaxseed extract in skin elasticity and distensibility. This study showed clearly the therapeutic effect of flaxseed extract on biologic tissue, including stimulation of microcirculation and improvement of fibroblastic cell activity. Elasticity evaluation demonstrated increased density and firmness in the network of collagen/elastic fibers in the dermis and subcutis during wound healing process promise in generating therapeutic gel to be used in wound healing process. Keywords: Flaxseed; elasticity; skin wound