Miracle-dz/UniFAR-FTUs huggingface dataset:
Genomic and Proteomic Pathway Mapping Reveals Signatures of Mesenchymal-Epithelial Plasticity in Inflammatory Breast Cancer

1.1 Inflammatory breast cancer as a distinct clinicopathologic entity There are several clinically distinct types of breast cancer, which include early stage breast cancer, locally advanced breast cancer (LABC) and metastatic breast cancer. The most rare but lethal form of LABC is inflammatory breast cancer (IBC) (reviewed in 1). This type of breast cancer accounts for an estimated 25% of all breast cancers in the United States and up to 20% of all breast cancers globally (2-4). Although primary IBC is less commonly diagnosed than other types of breast cancer, IBC is responsible for a disproportionate number of breast cancer-related deaths that occur each year world-wide due to its propensity to rapidly metastasize. (2-4). Women diagnosed with IBC have a significantly shorter median survival time (~ 2.9 years) than women with either LABC (~ 6.4 years) or non-LABC breast cancer (>10 years). The clinical diagnosis of IBC is based on the combination of the physical appearance of the affected breast, a careful medical history, physical examination, and pathological findings from a skin biopsy and/or needle or core
Strategic Directions in Computational Geometry Working Group Report

Computational geometry investigates algorithms for geometric problems. For an introduction to the eld, see the textbooks [Edelsbrunner 1987; Mulmuley 1994; O'Rourke 1994; Preparata and Shamos 1985] and the forthcoming handbooks [Goodman and O'Rourke 1997; Sack and Urrutia 1997]. Resources on the World Wide Web are also available (see, e.g., the Directory of Computational Geometry Software [Amenta ], the Computational Geometry Pages [Erickson ]), and Geometry in Action [Eppstein ]. This report outlines the evolution of computational geometry, discusses strategic research directions with emphasis on methodological issues, and proposes a framework for interaction between computational geometry and related applied elds.
Long‐Term Soil Organic Carbon as Affected by Tillage and Cropping Systems

The use of conservation tillage systems for corn (L.) and soybean [ (L.) Merr. ] production has increased in recent years because of several factors including their potential to reduce losses or sequester soil organic C (SOC). This study evaluated the effects on SOC of three cropping systems (continuous corn [CC], continuous soybean [CSB], and soybean–corn [SB-C]) in six primary tillage systems (chisel, disk, plow, no-till, ridge-till, and subtill) under rainfed conditions in southeastern Nebraska. Soil samples were collected in depth increments of 0 to 7.5, 7.5 to 15, and 15 to 30 cm in the fall of 1989 and 2004 after harvest and analyzed for SOC. No significant differences in SOC concentrations were obtained among tillage treatments in any depth in a partial sampling of a study that was done in 1989. Tillage treatment and cropping system both significantly affected SOC concentrations and reserves at all depths in 2004, but only bulk density at a few depths. No-till SOC reserves ranged from 4.8 to 11.6 Mg ha greater than SOC reserves in the other tillage treatments in the 0- to 30-cm depth. Similarly, SOC concentrations and reserves were greatest in CC and least in CSB, with intermediate values for SB-C in all tillage systems. Soil organic C levels were maintained or even increased in all tillage systems; however, the greatest increases were obtained in systems with the least amount of soil disturbance, which strongly supports the adoption and use of conservation tillage systems for soil sustainability.
Relatos de experiências em Recovery: Usuários como tutores, familiares como cuidadores/pesquisadores e efeitos destas práticas em docentes e pesquisadores em saúde mental

Sao relatadas duas experiencias centradas no recovery. Uma, com usuarios que participam regularmente, ha 10 anos, de atividades de docencia pratica em aulas de psicopatologia para alunos de psicologia e medicina; outra, com familiares engajados ha 5 anos em grupos de apoio mutuo e educacao em saude, e que compartilham experiencia de participacao em pesquisa avaliativa de servicos de saude mental. A partir destas duas experiencias se construiu um percurso metodologico baseado na autoetnografia e estudo das narrativas, tendo como ferramenta principal uma roda de conversa, reunindo usuarios, familiares e professores/pesquisadores, que se propuseram, de forma colaborativa e compartilhada, a produzir um estudo sobre os efeitos da experiencia de recovery nos tres grupos de participantes. O material foi audiogravado, transcrito, categorizado e interpretado, com base na analise das narrativas. O estudo, cujas limitacoes sao descritas, conclui que as experiencias de recovery produziram deslocamentos subjetivos de posicoes anteriormente fixas e rigidas, gerando efeitos positivos para a autoestima e empoderamento de usuarios e familiares, e para a reorientacao de percepcoes e conceitos sobre o adoecimento, tratamento e recuperacao, por parte dos docentes/pesquisadores. Como estudo exploratorio, necessita de novas fases de desenvolvimento, para comprovacao dos efeitos beneficos relatados e da adequacao da metodologia de autoetnografia aos estudos de recovery.
Gaussian distribution of inhomogeneous neutrino degeneracy and big bang nucleosynthesis

We explore the e ect of inhomogeneous neutrino degeneracy on big bang nucleosynthesis (BBN) in the case where such inhomogeneity is described by a Gaussian distribution. In particular, two cases are investigated: equal degeneracy for all three neutrino avors, and electronneutrino degeneracy alone. We show that element abundances increase with Gaussian width, and we conclude that Gaussian inhomogeneity actually narrows the range of the baryon-to-photon ratio .
Effects of freshwater stratification on nutrients, dissolved oxygen, and phytoplankton in the Bay of Bengal

Author Posting. © The Oceanography Society, 2016. This article is posted here by permission of The Oceanography Society for personal use, not for redistribution. The definitive version was published in Oceanography 29, no. 2 (2016): 222–231, doi:10.5670/oceanog.2016. 54.
Flow Cytometry in Preclinical Toxicology/Safety Assessment

The primary departmental goal of preclinical toxicology (a.k.a. safety assessment) in drug development is to identify and characterize drug-induced toxicity in test animals by using appropriate animal models. This is accomplished through a large number of individual studies, sometimes referred to as a “tox package,” designed to provide specific data on the pharmacology/toxicology of the drug candidate including determination of acute, subacute, and chronic toxicity, carcinogenicity, mutagenicity, teratogenicity, and effects on the reproductive system. Various study designs are employed. Dose ranging and/or dose escalating studies are typically completed early in the safety assessment phase of drug development. This study design is meant to provide maximum tolerated dose (MTD) and no observable (adverse) effect level (NOEL orNOAEL), two important pieces of information that aid in selection of doses for repeat dosing and/or chronic studies. Acute, single-dose experimental designs are also used early in the safety phase to identify organs/tissues that are targets of toxicity. After toxicity is identified, it is important to determine if the effect is reversible given that the animal is allowed to recover for a period of time after administration of the last dose. Reversibility studies may be done separately or a recovery group may be included in a particular study design. It is possible to use varying routes of administration across studies, but it is critical to sufficiently investigate the route intended
Introduction to an Architectural Theory: Design as Theory Application

Architect is not commissioned to do research, but to design. At his/her best, the architect may look at some built environments in the name of precedent studies. Debate whether architect need to do research or could the designing be theory application is growing. This paper aims at introducing truism of the disciplinary model, which is implicitly used in architectural research but seldom openly studied in philosophy of architecture. The key question is, whether theories of architecture are vehicles which the basis of the truism, the analogy from natural sciences, entails and whether relativity can be excluded from applying to architectural reality, as it seems to be done presently. At its best, truism may bring life to the dusty ghosts of the past and at its worst, forms a vicious circle of implicit rules of interpretation, a conspiracy of proper attitude passionately governed by gurus and adherents. First, the disciplinary model is described and examples given to exemplify its role in history writing. Finally, we conclude with remarks on the implications of the discussed disciplinary model. DOI: 10.4038/besl.v8i1. 1907 Built-Environment Sri Lanka Vol.8(1) 2008 20-22
Development of a Wearable Electroencephalographic Device for Anxiety Monitoring

Anxiety disorders are the most common mental illness in the U.S. affecting nearly 40 10 adults (18% of the U.S. Population). It has been shown that patients with recurring anxiety tend to be more suicidal and prone to depression [1,2]. Anxiety has also been proven to be an impeding factor in the rehabilitation time of subjects suffering from various diseases ranging from pulmonary afflictions [3] to cancer [4]. Detection of anxiety is commonly done through various tests conducted by psychologists [5], which are time consuming and not necessarily accurate. Recently, electroencephalographic (EEG) data have been shown to be useful in the case of most anxiety patients to detect the levels of anxiety [6–8]. Two of the key areas of the brain that are known to be affected by patients suffering from social anxiety are the occipital and frontal lobes [9,10]. EEG data are best explained through rhythms in the frequency domain: delta (1–4 Hz), theta (4–7 Hz), alpha (7–12 Hz), beta (12–30 Hz), and gamma (>30 Hz). Research in the field has shown that changes in the alpha feedback are commonly seen in high anxiety and neurotic patients [11,12] and alpha EEG biofeedback is commonly used in the management of anxiety [13,14]. It has also been suggested that anxiety can be detected through analysis of alpha-theta and theta waves of the EEG signals [15,16] while theta waves are most commonly seen in the case of animal experimentation of anxiety and fear [17]. Considering the importance of real-time observation and management of anxiety states in patients, we developed a wearable EEG device for anxiety monitoring and investigated the influence of induced anxiety on the responses of the brainwaves obtained from the occipital lobes.
Afobazole Activation of Sigma-1 Receptors Modulates Neuronal Responses to Amyloid-β

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a continual decline of cognitive function. No therapy has been identified that can effectively halt or reverse its progression. One hallmark of AD is accumulation of the amyloid-β peptide (A β ), which alone induces neuronal injury via various mechanisms. Data presented here demonstrate that prolonged exposure (1-24 hr) of rat cortical neurons to A β 25-35 results in an increase in basal intracellular Ca 2+ concentration ([Ca 2+ ] i ) and that co-incubation in the compound, afobazole, inhibits these [Ca 2+ ] i increases. The effect of afobazole on [Ca 2+ ] i is due to activation of σ -1 receptors, but could not be mimicked by a second pan-selective σ receptor agonist, 1,3-di-o-tolylguanidine (DTG). Afobazole was also found to lessen NO production in response to A application, but did not affect elevations in reactive oxygen species elicited by the A β fragment. The reductions in [Ca 2+ ] i and NO perturbation produced by afobazole were associated with a decrease in neuronal cell death, whereas DTG also failed to enhance cell survival. Examining the molecular mechanisms involved in the increased neuronal survival demonstrates that afobazole incubation results in lower expression of the pro-apoptotic protein Bax and the death protease caspase-3, while at the same time increasing expression of the anti-apoptotic protein, Bcl-2. Given the importance of A β neurotoxicity in AD etiology, the findings reported here suggest that afobazole may be an effective AD therapeutic agent. Furthermore, σ -1 receptors may represent a useful target for AD treatment, though not all σ ligands appear to be equally beneficial.
Optimization of Fuzzy Cluster Nodes in Cellular Multimedia Networks

The cellular network is one of the emerging areas of communication, in which the mobile nodes act as member for one base station. The cluster based communication is now an emerging area of wireless cellular multimedia networks. The cluster renders fast communication and also a convenient way to work with connectivity. In our scheme we have proposed an optimization technique for the fuzzy cluster nodes, by categorizing the group members into three categories like long refreshable member, medium refreshable member and short refreshable member. By considering long refreshable nodes as static nodes, we compute the new membership values for the other nodes in the cluster. We compare their previous and present membership value with the threshold value to categorize them into three different members. By which, we optimize the nodes in the fuzzy clusters. The simulation results show that there is reduction in the cluster computational time and iterational time after optimization. Keywords—Clusters, fuzzy and optimization.
AWARD NUMBER: W81XWH-09-1-0250 TITLE: The Role ERG and CXCR4 in Prostate Cancer Progression PRINCIPAL INVESTIGATOR:

s: Singareddy R, St. John J and Chinni, SR. Molecular characterization of ERG mediated CXCR4 transcriptional regulation. 102end annual American Association for Cancer Research. Orlando, FL. April 2-6, 2011. Chinni, SR. Singareddy R, and St. John J. Role of ERG and CXCR4 in prostate cancer progression. Innovative Minds in Prostate Cancer Today. Orlando, FL. March 912, 2011. Podium Presentation: The role of ERG and CXCR4 in Prostate Cancer Progression. Innovative Minds in Prostate Cancer Today. Orlando, FL. March 9-12, 2011. Role of ERG and CXCR4 in Prostate Cancer Bone Metastasis. 7 Annual National Symposium on Prostate Cancer. Clark Atlanta University, Atlanta, GA. May 23-24, 2011.
Winners and Losers: A Micro-Level Analysis of International Outsourcing and Wages

Our paper investigates the link between international outsourcing and wages utilizing a large household panel and combining it with industry level information on industries' outsourcing activities from input-output tables. This approach avoids problems such as aggregation bias, potential endogeneity bias and poor skill definitions that commonly hamper industry-level studies. We find that outsourcing has had a marked impact on wages. Applying two alternative skill classifications we find evidence that a one percentage point increase in outsourcing reduced the wage for workers in the lowest skill categories by up to 1.5% while it increased wages for high-skilled workers by up to 2.6%. This result is robust to a number of different specifications.
91.01 The central elements in Josef’s triangle

Notes 91.01 The central elements in Josefs triangle The general solution of the Fibonacci recurrence relation an = a„_i + a„-2 is an = Aa" + BfT, where a = (l + V5)/2 and /? = (l V5)/2 are the solutions of the quadratic equation x = x + 1 a" B and n > 3 [1]. When ai = 1 = a2, an = = F„, the nth a p Fibonacci number; when ct\ = 1 and a2 = 3, a„ = a" + fT = L„, the n th Lucas number; these are Binet's formulas for F„ and Ln, respectively. Both formulas can also be extended to zero and negative subscripts [2]. For example, F0 = 0 and LQ = 2. Both Fibonacci numbers and Lucas numbers continue to surprise us with their numerous applications and occurrences in quite unexpected places [2]. Many attempts have been made over the years to construct triangular arrays using Fibonacci and Lucas numbers. They have yielded intriguing dividends. In this article, we consider one such array. <— rowO a0 bx
Adversarial Web Search

Web search engines have become indispensable tools for finding content. As the popularity of the Web has increased, the efforts to exploit the Web for commercial, social, or political advantage have grown, making it harder for search engines to discriminate between truthful signals of content quality and deceptive attempts to game search engines' rankings. This problem is further complicated by the open nature of the Web, which allows anyone to write and publish anything, and by the fact that search engines must analyze ever-growing numbers of Web pages. Moreover, increasing expectations of users, who over time rely on Web search for information needs related to more aspects of their lives, further deepen the need for search engines to develop effective counter-measures against deception. In this monograph, we consider the effects of the adversarial relationship between search systems and those who wish to manipulate them, a field known as "Adversarial Information Retrieval". We show that search engine spammers create false content and misleading links to lure unsuspecting visitors to pages filled with advertisements or malware. We also examine work over the past decade or so that aims to discover such spamming activities to get spam pages removed or their effect on the quality of the results reduced. Research in Adversarial Information Retrieval has been evolving over time, and currently continues both in traditional areas (e.g., link spam) and newer areas, such as click fraud and spam in social media, demonstrating that this conflict is far from over.
Understanding the Spatio-temporal Pattern of Tweets

September 2013 769 Recent IT technologies and online services are tremendously altering the way people create, use and share geographic information (Elwood, 2008). Enabled by the widespread use of hand-handled GPS, geo-tags, high-resolution graphics and access to the Internet and Web 2.0, spatial data can be collected and produced voluntarily by the untrained general public. This has been termed Geoweb, Volunteered Geographic Information, and neogeography (Goodchild, 2007; Crampton, 2008). Different from the traditional way exclusive to professionals in collecting spatial data, an individual can be seen as an intelligent sensor contributing to local geographic information (Goodchild, 2007). This innovation profoundly impacts the discipline of geography, as well as sociology and politics, by providing innovative solutions other than traditional methods such as focus groups, interviews and surveys (Elwood, 2008; Tsou and Leitner, 2013). The Geoweb, according to Crampton et al. (2013), is not only a simple collection of latitude-longitude coordinates attached with information, but a “socially produced space that blurs the oft-reproduced binary of virtual and material spaces”. i n t r o d u c t i o n Understanding the
An Efficient Feature Selection Method for Multiple Time Series Clinical Data Classification

Patient’s condition description consists of combination and changes of clinical measures. Conventional data processing methods and classification algorithms may reduce the prediction performance of clinical data.Inorder to improve the accuracy of clinical data outcome prediction by using feature selection method with multiple measurement support vector machine(MMSVM) classification algorithm is proposed. Most popular primary liver cancer is hepatocellular carcinoma (HCC). It stands in the fifth position in the world considering the tumour ranking. HCC can be treated by using Radiofrequency ablation (RFA). Recurrence prediction of hepatocellular carcinoma (HCC) after RFA treatment is an important task. The proposed method uses Binary krill herd method as the feature selection method for classification of clinical data.This method can be used for prediction of Hepatocellular Carcinoma (HCC) recurrence. After data processing, multiple measurement support vector machine(MMSVM) is used as classification method to predict HCC recurrence.The method classify data into two classes-1) HCC recurrence and 2) no evidence of recurrence of HCC.The performance accuracy of HCC recurrence prediction was significantly improved by using the feature selection method.
Application of the Bayesian Approach to Incorporate Helium Isotope Ratios in Long-Term Probabilistic Volcanic Hazard Assessments in Tohoku, Japan

A challenge with the long-term probabilistic assessment of future volcanism in relation to the siting of, for example geological repositories is that because new volcano formation is rare, uncertainties in models are inherently large [10]. Sites for nuclear facilities in particular must be located in areas of very low geologic risk [11]. Recent studies have been carried out looking at the hazard posed by volcanoes to nuclear power plants in Armenia [e.g. 9, 12] and Java, Indonesia [e.g. 13]. Here the focus was more on the consequences of an eruption at an existing volcano on the safety of an operating nuclear power plant. In the case of a geological repository for high and/or low level radioactive waste, the emphasis is on the consequences of new igneous activity such as a dike that may intrude the repository [e.g. 14] and transport the waste to the surface. In this case, the probability of a new volcano forming in the first place is very low (typically < 10-7/a) since by definition such facilities should be located away from existing Quaternary volcanoes. However the lack of volcano ‘data’ implies that addition information on the processes that control future long-term spatio-temporal distribution of volcanism are
Are men and women equally corrupt ? U 4

The belief that women are less corrupt than men is widespread, even among development specialists. Variations in risk aversion and reciprocal behaviour may partially explain gender differences in corrupt behaviour and provide some guidance for policy choice. However, nurture seems to trump nature, and contextual factors appear to be the main causes of the observed differences in corrupt behaviour. Ultimately, even if there is no evidence that women are intrinsically less corrupt than men, increasing women’s participation is still a desirable policy choice. Even if it were not to reduce corruption directly, it would contribute to gender equality.
Thermodynamic reversibility in feedback processes

The sum of the average work dissipated plus the information gained during a thermodynamic process with discrete feedback must exceed zero. We demonstrate that the minimum value of zero is attained only by feedback-reversible processes that are indistinguishable from their time-reversal, thereby extending the notion of thermodynamic reversibility to feedback processes. In addition, we prove that in every realization of a feedback-reversible process the sum of the work dissipated and change in uncertainty is zero.
SAMPLED-DATA DISTRIBUTED H∞ CONTROL OF TRANSPORT REACTION SYSTEMS∗

We develop, for the first time, sampled-data distributed H∞ control of a class of parabolic systems. These systems are governed by one-dimensional semilinear transport reaction equations with additive disturbances. A network of stationary sensing devices provides spatially averaged state measurements over the N sampling spatial intervals. We suggest a sampled-data controller design, where the sampling intervals in time and in space are bounded. Our sampleddata static output feedback enters the equation through N shape functions (which are localized in the space) multiplied by the corresponding state measurements. Sufficient conditions for the internal exponential stability and for L2-gain analysis of the closed-loop system are derived via direct Lyapunov method in terms of linear matrix inequalities (LMIs). By solving these LMIs, upper bounds on the sampling intervals that preserve the internal stability and the resulting L2-gain can be found. Numerical examples illustrate the efficiency of the method.