Miracle-dz/UniFAR-FTUs huggingface dataset:
QSAR and docking studies on inhibition of carbonic anhydrase tumorassociated isoenzyme IX with heterocyclic sulfonamides as cytotoxic agents

Carbonic anhydrases (CAs) are metalloenzymes containing one zinc ion (Zn2+) per polypeptide chain. Sulfonamide derivatives incorporating substituted triazine ring have been investigated as excellent cytotoxic agents that inhibiting carbonic anhydrase tumor-associated isoenzyme IX.QSAR and docking studies for45 sulfonamide derivatives were performed. Twenty two QSAR models were constructed each model contain eight equations. The best of these models was chosen based on its statistical validation parameters where the R2 value was 0.98. Top model was returned based on six molecular descriptors; two fast descriptors, two spatial descriptors and two VAMP electrostatics descriptors. External validation of the developed model was governed by calculating the predicted biological activity and the residual values for training and test sets. These calculated values revealed a high prediction ability of our developed model. Molecular docking study aims to interpret the comparative differences in the binding interactions of these compounds at molecular level as inhibitors of CA IX.The sulfonamide (-SO2NH2) group of all docked compounds form hydrogen bond with Thr199 and is coordinated to zinc ion in the active site. Docking study revealed that the potency of the inhibitors was reduced by the presence of either bulky alkyl, orphenoxy substituent on the triazine ring. The potency was markedly enhanced by the presence of free aminoor amino acid substituents on triazine ring
Low-Wage Temporary Employment: The Structural Demobilization of Human Agency in Labour Market Advancement

My interest in the structure of temporary employment began while observing two relatively low-wage temporary clerical workers (database entry positions) at one of my former jobs. I noticed the excessive workload the less-experienced worker (Anne) undertook to impress managers in the workplace. The two workers had diff erent levels of seniority: Tracy had been in the department for two years and Anne for one year. Anne voluntarily took on more tasks for multiple projects, whereas Tracy assumed fewer tasks for fewer projects. As a result, Anne was invited to a staff retreat with the department’s permanent employees while Tracy was excluded. The day following the retreat, Tracy complained about the lack of invitation and felt the managers acted disrespectfully by not inviting her despite her seniority. The hiring managers were not obligated to invite any temporary workers to the retreat, but may have seen it as an opportunity to enforce an illusive mentality of reaping the fruits of your labour. This system of exclusion within the context of temporary employment creates a new form of exploitation. The above scenario is problematic in that it presents the illusion that temporary employees can advance into full-time permanent employment if they simply work hard enough. However, Parker (1994) found that though temporary clerical workers express a preference for full-time, year-round employment, the extent to which they successfully transition is signifi cant
Global and long-term comparison of SCIAMACHY limb ozone profiles with correlative satellite data (2002–2008)

Abstract. SCIAMACHY limb scatter ozone profiles from 2002 to 2008 have been compared with MLS (2005–2008), SABER (2002–2008), SAGE II (2002–2005), HALOE (2002–2005) and ACE-FTS (2004–2008) measurements. The comparison is performed for global zonal averages and heights from 10 to 50 km in one km steps. The validation was performed by comparing monthly mean zonal means and by comparing averages over collocated profiles within a zonal band and month. Both approaches yield similar results. For most of the stratosphere SCIAMACHY agrees to within 10% or better with other correlative data. A systematic bias of SCIAMACHY ozone of up to 100% between 10 and 20 km in the tropics points to some remaining issues with regard to convective cloud interference. Statistical hypothesis testing reveals at which altitudes and in which region differences between SCIAMACHY and other satellite data are statistically significant. We also estimated linear trends from monthly mean data for different periods where SCIAMACHY has common observations with other satellite data using a classical trend model with QBO and seasonal terms in order to draw conclusions on potential instrumental drifts as a function of latitude and altitude. Since the time periods considered here are rather short these trend estimates are only used to identify potential instrumental issues with the SCIAMACHY data. As a result SCIAMACHY exhibits a statistically significant negative trend in the range of of about 1–3% per year depending on latitude during the period 2002–2005 (overlapping with HALOE and SAGE II) and somewhat less during 2002–2008 (overlapping with SABER) in the altitude range of 30–40 km, while in the period 2004–2008 (overlapping with MLS and ACE-FTS) no significant trends are observed. Since all correlative satellite instruments do not show to a very large extent statistically significant trends in any of the time periods considered here, the negative trends observed with SCIAMACHY data point at some remaining instrumental artifact which is most likely related to residual errors in the tangent height registration of SCIAMACHY.
Simulating Hydrological Patterns and Potential Irrigable Agricultural Lands Using Remote Sensing and GIS

It was aimed to determine potentially irrigable lands of Canakkale province using Digital Elevation Model (DEM). DEM were obtained by digitizing 1:25000 scaled topographic maps to investigate the terrain features. Hydrologic analysis was conducted using ArcHydro module that attached with ArcGIS software. Flow directions, flow accumulations, catchment grids, catchment polygons, drainage lines and drainage points were delineated. In order to determine water bodies and agricultural lands, Land Use and Land Cover (LULC) map was generated using Landsat TM 5 image. According to the results, 206 catchments were identified within study area. Among these catchments, water found to be cumulated on 47 catchments within 27 natural or man-made water collection units. It was seen that water would be able to transfer from these units to 136 catchments. The agricultural lands within these catchments with land use capability class value varying 1-3, and slope values varying 0-8%, defined as Potentially Irrigable Lands in this study (131016 ha).
Clustering Analysis within Text Classification Techniques

The paper represents a personal approach upon the main applications of classification which are presented in the area of knowledge based society by means of methods and techniques widely spread in the literature. Text classification is underlined in chapter two where the main techniques used are described, along with an integrated taxonomy. The transition is made through the concept of spatial representation. Having the elementary elements of geometry and the artificial intelligence analysis, spatial representation models are presented. Using a parallel approach, spatial dimension is introduced in the process of classification. The main clustering methods are described in an aggregated taxonomy. For an example, spam and ham words are clustered and spatial represented, when the concepts of spam, ham and common and linkage word are presented and explained in the xOy space representation.
How Does Board Structure Characteristics Affect Capital Structure Decisions? Evidence from East African Stock Markets

This research examines the board structure characteristics and its effects on capital structure decisions in developing economies, East African stock markets. To achieve the objective of this research, we used a strongly balanced panel dataset of 320 observations (i.e. a sample of 32 non-financial listed firms in East African region from 2006-2015. Measures for capital structure decisions were short term debt ratio (STDR),long term debt ratio (LTDR) and total debt ratio (TDR) as dependent variables and explanatory (independent) variable was board structure characteristics measured by researcher-constructed index consisting of 10 board structure characteristics provisions; thus the board structure characteristics index (BSCI), furthermore, the effects of control variable such as firm size (SIZ),the level of economic development (GDP) and industry dummies were also examined. The panel corrected standard errors (PCSEs) regression model was employed for board structure characteristics and capital structure decisions to analyze the data. Our results indicate a statistically significant negative effect of board structure characteristics on capital structure decisions (except on short term debt where it’s insignificant) all models at 5% significance level. Our study is very innovative in both corporate finance and accounting literature and the practical implications because our study provides a first insight of the board structure characteristics and its effects on capital structure decisions for East African stock markets context. The study recommends to securities markets regulatory authorities in East African region such as East African member states securities regulatory authority (EASRA) and their respective countries securities markets regulatory authorities to stimulates new efforts towards better board structure provisions to listed firms in the regional bloc due to its statistically significant effects on financing behavior and future research can be extended after inclusion of both listed and unlisted firms.
Customer Demand Discovery for New Product Design

Collecting and investigating customer demand is a critical success factor for new product design and development. This paper presents a set of customer requirement discovery methodologies to achieve wide and complex market investigations. Our approach supports flexible questionnaire model and uses data mining technologies. The discovery rule can be flexible defined. By using our rule mining methodology, the complete customer multipreference patterns are discovered and the statistic analysis results are calculated for new product design. A software system that allows for on-line customer feedback collection, digitisation of the language feedbacks and numerical descriptions of customer preferences of a product is developed for this approach. Our approach also links the customer demand analysis data with new product design procedure. The system could significantly shorten the survey and analysis time and is thus expected to help companies to reduce design cycle time for new products.
Impact of pain on the outcome of group psychotherapy

This ex post facto study investigated the influence of pain among patients with major depression on the outcome of group psychotherapy, after controlling for the effects of type of psychotherapy received, use of antidepressant medication, and alexithymia (in order to account for patients' tendencies to somatise unpleasant, negative feelings). We analyzed data from 48 psychiatric outpatients with comorbid major depression and complicated grief that participated in a randomized trial of two forms of group psychotherapy for complicated grief. Self-reported pain was assessed using the SF-36 Bodily Pain subscale. The Beck Depression Inventory, Brief Symptom Inventory- 53, and the Social Adjustment Scale were used to assess various outcomes of psychotherapy. Alexithymia was assessed with the Toronto Alexithymia Scale. Greater pain at baseline was associated with less improvement in depressive symptoms, general psychiatric distress, and social functioning after 12 weeks of group psychotherapy. Pain accounted for 13-21% of outcome variance. The negative effect of pain was consistent across both types of group therapy. Use of antidepressant medication did not differentially affect the impact of pain on treatment outcome. Recognizing and treating comorbid pain may enhance psychotherapeutic treatment outcomes of depressed patients.
Multi-layer Dialogue Annotation for Automated Multilingual Customer Service

For the AMITIES multilingual human-computer dialogue project [1], we have developed new methods for the manual annotation of spoken dialogue transcriptions from European financial call centers on multiple levels. We have modified the DAMSL schema [2] to create a dialogue act taxonomy appropriate to the functions of call center dialogues. We use a domain-independent framework populated with domain-specific lists to capture the semantics of spoken dialogues. Our new flexible, platform-independent Java annotation tool, called XDMLTool, takes plain-text dialogue files as input, and yields annotated files in the widely used XML format. To date, XDMLTool has been used to annotate several hundred call-center dialogues in France, the UK and the US. We present definitions of each tag as well as examples in English and French. These annotation methods are developed for an experimental system that automates financial call centers in Europe. The multi-level annotation scheme has been used to develop a prototype triaging application for financial services.
On the existence of jet schemes logarithmic along families of divisors

A section of the total tangent space of a scheme X of finite type over a field k, i.e. a vector field on X, corresponds to an X-valued 1-jet on X. In the language of jets the notion of a vector field becomes functorial, and the total tangent space constitutes one of an infinite family of jet schemes Jm(X) for m ≥ 0. We prove that there exist families of “logarithmic” jet schemes JD m(X) for m ≥ 0, in the category of k-schemes of finite type, associated to any given X and its family of divisors D = (D1, . . . , Dr). The sections of JD 1 (X) correspond to so-called vector fields on X with logarithmic poles along the family of divisors D = (D1, . . . , Dr). To prove this, we first introduce the categories of pairs (X,D) where D is as mentioned, an r-tuple of (effective Cartier) divisors on the scheme X. The categories of pairs provide a convenient framework for working with only those jets that pull back families of divisors.
Elk habitat use within a rest-rotation grazing system.

Competition between wildlife and domestic livestock on public lands has long been of concern to the public and to wildlife and land managers. As a result, resource managers in Montana and other states have conducted a number of studies to define the relationship between livestock and wildlife range use patterns. Studies in Montana have documented conflicts in wildlife and domestic livestock range use of public lands. While these studies define conflicts between cattle and wildlife, they do not adequately identify practical approaches to resolve that conflict. To address this issue, the Montana Department of Fish, Wildlife and Parks began a program in 1977 to combine existing research with sound range management principles. The goal is to design a grazing system that resolves conflicts between domestic livestock and wildlife on summer ranges with specific emphasis on providing abundant, high quality habitat for wildlife, principally elk. The system implemented by the Department on the Mount Haggin Wildlife Management Area incorporates grazing principles described by Hormay (1970). The system was fully opera-
Movements and use of home range in the Iriomote cat (Prionailurus bengalensis iriomotensis)

Movement pattern of the Iriomote cat Prionailurus bengalensis iriomotensis was studied on Iriomote Island, Japan by radio-tracking. The influence of sex and reproductive status of cats on their daily movement distance (DMD), straight-line distance (SLD), daily movement range (DMR) and other relative indices of movements was estimated. DMD was longest in males (3.2 km) and shortest in females without kittens (1.9 km). Also, males moved faster than either females with or without kittens (0.34, 0.25 and 0.25 km/h, respectively). During the mating season, males moved faster and their DMRs were larger than during the rest of the year. The SLD/DMD ratio in males was similarly high in both seasons (0.29 and 0.33), which indicates that their daily routes were expanded over large areas year-round, possibly to maintain a continuous control over their home range. In contrast, SLD/DMD varied seasonally in breeding females. It was low (0.09) during the lactating period, when females returned repeatedly to the den with kittens and it became high (0.32) out of the breeding season. Breeding females moved equally long DMDs in both seasons, whereas non-breeding ones moved shorter distances during the breeding period. These differences may be related to seasonal changes of food abundance. Cats moved intensively, as indicated by long (812–1139 m) routes per km2 of their home range, and occasionally visited distant parts of their ranges in a short time (4–5 days). On the other hand, they showed a relatively slow increase of the patrolled area, from 10% to 36% of their home ranges, in the first and fifth day, respectively. Movement pattern of Iriomote cats showed no clear relation to active defence of home ranges.
Superconducting microstrip amplifiers with sub-Kelvin noise temperature near 4 GHz

We present measurements of an amplifier operating at 3.8 GHz with 150 MHz of bandwidth based on the microstrip input-coil resonance of a dc superconducting quantum interference device (SQUID) with submicron Josephson junctions. The noise temperature is measured using two methods: comparing the signal-to-noise ratio of the system with and without the SQUID in the amplifier chain, and using a modified Y-factor technique where calibrated narrowband noise is mixed up to the SQUID amplifier operating frequency. With the SQUID cooled to 0.35 K, we observe a minimum system noise temperature of 0.55 ± 0.13 K, dominated by the contribution from the SQUID amplifier.
The co-management of the sand eel fishery of Catalonia (NW Mediterranean): the story of a process

A management plan for the boat seines, called sonsera , used in Catalonia to target sand eels ( Gymanammodytes cicerelus and G. semisquamatus ) and transparent gobies was drawn up in accordance with European Union rules. A Sand Eel Co-Management Committee was formally created with the specific mission of ensuring a sustainable fishery. The Committee is composed of public administrations, fishermen’s associations, researchers and NGOs. The process has two phases: first, a comprehensive study of the fishery and subsequent advice for the establishment of a management plan and, second, the implementation and monitoring of the management plan. The study of the fishery included the analysis of the ecosystem impacts of the fishery (mainly stock status, impact on sensitive habitats and by-catch) and was carried out in the wider context of an adaptive co-management process to respond to the requirements of an ecosystem approach to fisheries.
miRNA-30d serves a critical function in colorectal cancer initiation, progression and invasion via directly targeting the GNA13 gene

MicroRNAs (miRNAs or miRs) are reported to be dysregulated in the progression and invasion of various human cancer types, including colorectal cancer (CRC). They are also reported to be molecular biomarkers and therapeutic targets in CRC. miRNAs serve functions in a plethora of biological processes, including proliferation, migration, invasion and apoptosis, and several miRNAs have been demonstrated to be involved in CRC carcinogenesis, invasion and metastasis. Aberrant miR-30d expression and its effects have been reported in certain cancer types. However, the function and underlying mechanism of miR-30d in the progression of CRC remains largely unknown. In the current study, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was performed to quantify miR-30d expression in CRC tissues. In vivo and in vitro functional assays indicated that miR-30d inhibits CRC cell proliferation. Target prediction online software packages, miRBase, TargetScan and miRANDA, and luciferase reporter assays were used to confirm the target gene GNA13. Specimens from 45 patients with CRC were analyzed for correlation between the expression of miR-30d and the expression of target gene GNA13, evaluated by RT-qPCR. miR-30d was downregulated in CRC tissues and cell lines. Ectopic expression of miR-30d inhibited cell proliferation and invasion and tumor growth ability. By contrast, inhibition of endogenous miR-30d promoted cell proliferation and tumor growth ability of CRC cells. It was indicated that miR-30d directly targets the 3′-untranslated region of the GNA13 gene. Downregulation of miR-30d led to the activation of cell proliferation in CRC. In addition, miR-30d expression was negatively correlated with the expression of GNA13 in CRC tissues. In conclusion, miR-30d inhibits cancer initiation, proliferation and invasion in colorectal cancer via targeting GNA13.
Algo+naEscola, Ambiente para Apoio ao Ensino de Programação

Este artigo define o ambiente Algo+naEscola que fornece ao professor, um auxilio ao uso da logica computacional atraves de jogos na sala de aula. Os requisitos desse ambiente foram propostos atraves de um experimento do ensino de Matematica utilizando algoritmos e jogos. A ideia do trabalho de campo foi, de maneira interdisciplinar, desenvolver o ensino de ângulos atraves do uso de algoritmos e programacao de computadores. Esse experimento foi desenvolvido durante aulas de Matematica com alunos do ensino Fundamental II, sendo a base para construcao do ambiente Algo+naEscola.
Oxygen isotope and paleobotanical estimates of temperature and δ18O–latitude gradients over North America during the early Eocene

Empirical estimates of climate parameters such as mean annual tempera- ture (MAT) are essential to describe both ancient climate and to ground truth climate model simulations of past climates. In terrestrial settings, no single proxy record is able to provide detailed temporal yet geographically widespread information, and it thus becomes essential that paleoclimatic information obtained from different proxies be comparable. As an example of how to compare estimates, and to illustrate what can be learned by doing so, we measured oxygen isotope ratios of phosphate in the tooth enamel of fossil mammals and the body scales of freshwater fish in order to estimate the mean annual temperature (MAT) in which they lived. The samples were collected from Paleogene rocks of the Bighorn, Green River, and Powder River basins of Wyoming. Earliest Eocene samples provide MAT estimates that are similar to MAT estimates for the same times and areas obtained from leaf margin analysis. Further- more, isotopic data from the Paleocene Eocene Thermal Maximum (PETM), which has not yet yielded fossil floras, indicate a significantly higher MAT of 26°C. We also used temperature estimates obtained by both methods to investigate paleoelevation and to reconstruct geographic patterns of MAT over North America for the early Eocene. Larger Laramide basins have higher temperatures and lower inferred eleva- tions compared to associated volcanic highlands where cooler temperatures are consistent with substantial elevations. In turn, latitudinal gradients in temperature indicate that warming centered on polar regions played an important role during the Eocene "hothouse". Lastly, we show that the reconstructed Eocene relation between oxygen isotope ratios of precipitation and MAT is significantly different from the modern relation between these two variables. Because the relation has changed over time, the modern correlation should not be used to estimate paleo-MAT from measurements of oxygen isotope ratios in fossil material.