Miracle-dz/UniFAR-FTUs huggingface dataset:
Estudio de polimorfismos en non-coding RNA en Síndrome de cáncer de mama y ovario hereditario

RESUMEN: Desde hace un tiempo se viene estudiando la relación entre polimorfismos de non-coding RNA y la posible predisposición a padecer diferentes tipos de cáncer. En este trabajo se ha estudiado la correlación entre polimorfismos de un solo nucleótido (SNPs) en 5 genes (miR-146A, miR-196A2, miR-499A y dos SNPs de HOTAIR) y la predisposición a desarrollar cáncer de mama y ovario. El tamaño de la muestra estudiada fue de 99 pacientes y 133 controles. El método utilizado para el análisis del genotipo de las muestras fue la discriminación alélica por sondas Taqman (genotipado) y, posteriormente, se sometió a análisis estadístico, con el que se pudo observar que ninguno de los genotipos estudiados mostró diferencias estadísticamente significativas entre pacientes y controles. Con los resultados obtenidos (p > 0,05 en todos los casos) se pudo concluir que la presencia de SNPs en los genes estudiados no está relacionada con la predisposición a desarrollar cáncer de mama y ovario en la población estudiada.
Development of a Destination Image Recovery Model for Enhancing the Performance of the Tourism Sector in the Developing World

This chapter is based on a doctoral thesis on the development of a destination image (DI) recovery model for enhancing the performance of the tourism sector in Zimbabwe. The study was prompted by the failure of African destinations to develop DI image recovery models. A pragmatist paradigm, a convergent parallel mixed methodology research approach and a cross sectional survey were adopted. A sample of three hundred and nineteen comprising international tourists, service providers and key informants was used. A structured, semi-structured questionnaire and semi-structured interview guide were used respectively. Quantitative data was analyzed using the Statistical Package for Social Sciences (SPSS) and AMOS version 25 while qualitative data was analyzed using NVivo version 12. Tests were conducted using descriptive statistics, exploratory factor analysis, and confirmatory factor analysis. Structural Equation Modeling (SEM) was used to analyze the multiple independent variables. The major findings were that price, ancillary services and amenities significantly influenced affective image while ancillary services significantly influenced destination performance. The study recommended that the Ministry of Environment, Climate, Tourism and Hospitality Industry trains tourism stakeholders including the host community in order to achieve sustainable destination image recovery.
Copper in Alzheimer’s disease: Implications in amyloid aggregation and neurotoxicity

The relationship of copper dyshomeostasis with neurodegenerative diseases has become evident in the last years. Because of the major role that this metal ion plays in biological processes, most of which being located in the brain, it is not surprising that changes in its distribution are closely related with the advent of neurodegenerative disorders such as Alzheimer’s disease (AD). An increasing number of works have dealt with this subject in the last years, and opened an intense debate in some points while raising new questions that still remain unanswered. This revision work puts together and discusses the latest findings and insights on how copper ions are involved in AD progression, including its interaction with Aβ and its consequently induced aggregation.
Changes of Light Components and Impacts on Interannual Variations of Photosynthesis in China Over 2000–2017 by Using a Two‐Leaf Light Use Efficiency Model

Diffuse radiation produces a higher light use efficiency (LUE) than does direct radiation. However, light components and their impacts on interannual variations of photosynthesis in China have not been intensively studied. We estimated gross primary production (GPP) from a two‐leaf LUE model that incorporates a diffuse radiation effect and compared it with a big‐leaf LUE model that ignores the diffuse radiation impact. The results show that a dimming occurred in China—the estimated annual photosynthetically active radiation (PAR) declined by −1.79 MJ m−2 yr−1. However, the diffuse fraction and diffuse PAR increased over this interval. Both GPP models simulated an increasing trend of GPP in China from 2000 to 2017. The big‐leaf GPP model underestimated the increasing trend of GPP from the two‐leaf GPP model by 6.4%. The diffuse fraction change during the dimming exerted an embedded positive impact relative to the big‐leaf GPP trend in China.
Smart wetting of permeable pavements as an evaporative-cooling measure for improving the urban climate during heat waves

An urban microclimate model is used to design a smart wetting protocol for multilayer street pavements in order to maximize the evaporative cooling effect as a mitigation measure for thermal discomfort during heat waves. The microclimate model is built upon a computational fluid dynamics (CFD) model for solving the turbulent air, heat and moisture flow in the air domain of a street canyon. The CFD model is coupled to a model for heat and moisture transport in porous urban materials and to a radiative exchange model, determining the net solar and thermal radiation on each urban surface. A two-layer pavement system, previously optimized for maximal evaporative cooling applying the principles of capillary pumping and capillary break, is considered to design a smart wetting protocol answering the questions “when,” “how much,” and “how long” a pavement should be artificially wetted. It was found for the current optimized pavement solutions that a daily amount of 6 mm wetting over 10 min in the morning, preferentially between 8:00 and 10:00, guarantees a maximal evaporative cooling for 24 h during a heat wave.
In situ kinetics of self-assembly by surface plasmon resonance spectroscopy

Using surface plasmon resonance (SPR) spectroscopy in the Kretschmann configuration, we followed the self-assembly of organic ultrathin films which resulted from exposure of gold surfaces to solutions of CH3(CH2)n-1SH (n = 8, 12, 16, and 18) in ethanol and heptane. We monitored film growth in situ and continuously for up to 72 h with an overall thickness resolution of <1 A. Film dielectric constants, necessary for accurately calculating average film thicknesses from SPR spectra, were determined unambiguously for fully formed films by comparing spectra from organic films in different solvents. In addition, we introduce a novel two-color SPR experiment with which we can obtain both film thickness and film dielectric constant without changing solvents. We studied the chain length dependent and concentration dependent kinetics of film formation in ethanol and found that there are at least three distinct kinetics steps. The kinetics of the first, most rapid, step and the third, slowest, step can be described w.
Micro-Raman—A Tool for the Heavy Mineral Analysis of Gold Placer-Type Deposits (Pianu Valley, Romania)

In the current study, different heavy minerals typical of gold placer deposits were identified by means of micro-Raman spectroscopy, and their chemical composition analyzed and discussed (garnet, kyanite, staurolite, zircon, allanite, monazite, xenotime, rutile, anatase, cassiterite, titanite, barite). Even complex solid solution series, such as those of garnets, can be deciphered with the aid of systematic trends observed in Raman line frequencies. The ν1 mode in garnets will shift from high to low frequencies as a function of the ionic radius of the X2+ cation, from Mg2+, to Fe2+ and Mn2+, while the presence of Ca2+ will make the band to be shifted strongly to even lower wavenumbers. This approach has successfully been taken to differentiate between polymorph triplets such as kyanite-sillimanite-andalusite and rutile-anatase-brookite. Minerals under consideration with high contents of REE, U and Th are affected by intensive metamictization, particularly zircon and titanite. Raman peak features, such as shape, symmetry and intensity, respond to this radiation damage of the lattice and enable fine-tuning of these heavy minerals, such as in the case of fluorite (fetid fluorite).
Banking on bullshit: indifferences towards truth in corporate social responsibility

Purpose: This study aims to identify and deconstruct bullshit in banks' corporate social responsibility (CSR) communication to advance the management rhetoric research space, which has been characterised by an indifference to truth and meaning. Design/methodology/approach: Based on the management rhetoric theory, the study provides a typology of bullshit phenomena overview in the banking sector and follows McCarthy et al.'s (2020) Currency, Reliability, Authority, and Purpose/Point of View (C.R.A.P.) framework to showcase how bullshit can be comprehended, recognised, acted against and prevented. Findings: This paper puts a spotlight on written and spoken language to detect bullshit in banks' CSR statements. It provides actionable insights into how stakeholders can act against and prevent bullshit statements from occurring in the future. Research limitations/implications: Future research is warranted to assess the use of still imagery, events and video materials in corporate communications and non-financial reporting. Further rigorous assessment of actual CSR initiatives must be undertaken to assess claimed contributions. Practical implications: Monitoring mechanisms and independent assurance statements prepared by authorised third parties may strengthen the motivation and ethicality of CSR activities. Originality/value: This viewpoint is the first to follow the C.R. A.P framework and critically assess indifferences towards truth in banks' CSR communications.
Health-Related Factors in Rural and Urban Mexican Adolescents: The HELENA-MEX Study

Mexico shows a high prevalence of obesity in children and adolescents. Geographical location and cultural environment could play a role in the promotion of healthy lifestyles in terms of physical activity (PA), sedentary behavior (SB) and nutrition. The purpose of this study was to assess rural and urban differences in body composition (BC), physical fitness (PF), PA and nutritional status of adolescents from the state of Jalisco (Mexico). The study involved 469 students aged 13-17 years (55.0% girls) from 8 high schools. BC was analyzed by bioimpedance, and PF by standardized field tests. Objective measurements of PA and SB were taken in a subsample (n=240). Energy intake (EI) was calculated from two 24h recalls. Rural residents presented a higher prevalence of overweight, waist circumference, trunk fat mass, regional fat free mass and muscle handgrip strength (all p<0.05, ηp2<0.06). Cardiorespiratory fitness was similar among participants, whereas urban adolescents showed higher muscle power, speed-agility and flexibility scores (all p<0.05, ηp2<0.07). Overall lifestyle behavior in urban adolescents was more sedentary (p<0.05, ηp2= 0.11). EI was similar in both locations. In conclusion, urban Mexican adolescents presented a generally higher sedentary behavior and better fitness and fatness profile than their rural peers.
On an environmental sustainability problem

Beltratti et al proposed an environmental sustainability problem and stressed the importance of two related control problems, namely, the discounted utilitarian problem and the long‐run utility problem. From the analysis of the latter, they obtained the definition of the Green Golden Rule (GGR). We discuss the optimal steady‐state solutions of the first problem and provide new results, completing the known information on it. Then we tackle the second problem and its equivalent NLP problem of maximizing the steady‐state utility. We obtain that the solutions to the NLP problem depend on the capital accumulation features, like those of the first problem. This corrects and completes the original analysis of the GGR.
Optical and Structural Studies of Binary Compounds by Explosive Laser Irradiation and Heat Treatment

The chalcogens are the name for the periodic table group 16 (old-style: VIB or VIA) in the periodic table. It is sometimes known as the oxygen family. It consists of the elements oxygen (O), sulfur (S), selenium (Se), tellurium (Te), the radioactive polonium (Po), and the synthetic ununhexium (Uuh). Their compounds, particularly the sulfides, selenides and tellurides are collectively known as chalcogenides. Binary compounds of the chalcogens are called chalcogenides (rather than chalcides, which breaks the pattern of halogen / halide and pnictogen / pnictide). Chalcogenide compounds have the structure mostly composed of segments, chains and molecules. The primary covalent type structure prevailing within the chains of segments in particular a weak one. The materials of low covalent bond strength shows optical transparency in the mid to far IR. While the chalcogenide glasses (Boer & Ovshinsky, 1970; Collins, 1970; Zope M & Zope J, 1984; Afifi et al., 1988; Fadel & El-Shair , 1992 & Fadel et al. ,1992) are regarded as weakly bonded materials in contact to oxide glasses containing both types of heteropolar and homopolar covalent bond viz. Ge-Se, Ge-S etc. and Se-Se, S-S etc. Substantial number of the works on chalcogenide glasses were pointed towards device making games in memory thin film electronic switches (von Allmen, 1987 & Fadel, 1993). Although the applications are manifold yet the necessary structures are still to be understood in the sense of transition between amorphous to crystalline states (Brice,1986). A tendency towards attaining glassy states for ternary chalcogenide glasses increases in the following order
European option pricing models described by fractional operators with classical and generalized Mittag‐Leffler kernels

In this paper, we investigate novel solutions of fractional‐order option pricing models and their fundamental mathematical analyses. The main novelties of the paper are the analysis of the existence and uniqueness of European‐type option pricing models providing to give fundamental solutions to them and a discussion of the related analyses by considering both the classical and generalized Mittag‐Leffler kernels. In recent years, the generalizations of classical fractional operators have been attracting researchers' interest globally and they also have been needed to describe the dynamics of complex phenomena. In order to carry out the mentioned analyses, we take the Laplace transforms of either classical or generalized fractional operators into account. Moreover, we evaluate the option prices by giving the models' fractional versions and presenting their series solutions. Additionally, we make the error analysis to determine the efficiency and accuracy of the suggested method. As per the results obtained in the paper, it can be seen that the suggested generalized operators and the method constructed with these operators have a high impact on obtaining the numerical solutions to the option pricing problems of fractional order. This paper also points out a good initiative and tool for those who want to take these types of options into account either individually or institutionally.
Risk Factors for Depression Among Returnee Migrants and Non-migrants Working Adults in Nepal: A Cross-Sectional Community Based Study

Background: Mental health is a growing concern worldwide. It is not well understood whether Nepali workers, including international labour migrants from Nepal, are at higher risk of developing mental health problems. The purpose of our study is to determine the prevalence of and examine the risks factors for depression among returnee migrants and non-migrant working male adults in Nepal. Methods: A cross-sectional survey of a probability-based sample of 725 participants was conducted in February 2020. The sample was comprised of two groups based on migration status: returning migrants and non-migrants. Logistic regression was applied to investigate factors associated with symptoms depression.Results: The overall prevalence of depression was 10.1%. However, the prevalence of depression was lower (7%) among returnee migrants compared to non-migrants (13.7%). Participants in the lower income group were more at risk of depression (OR=5.38, 95% CI: 1.96-14.78) than those in the higher income group. Similarly, Buddhists and Christians were more likely to be depressed (OR=2.17, 95% CI: 1.02-4.64) than Hindus. Interestingly, participants having more than two children had a higher prevalence of depression (OR=5.14, 95% CI: 1.22-21.63) compared with those having no children. Unmarried participants were more likely to be depressed (OR=4.05, 95%, CI:1.10-14.93) than those who were married. Conclusion: The working Nepali adult male population in Nepal, including returning migrants, is at risk of depression, but this risk is lower in those in the higher income group, returnee migrants, married, Hindus and those with no children. This study highlights the need to monitor and develop national policies to ensure the mental health of Nepali male adult population, including returnee migrants.
The Impact Of Gelatin Weight Ratio On Hydroxyapatite-gelatin Composites And Their SBF Behaviour

Summary Hydroxyapatite is a bioceramic owing biocompatibility, bioactivity, osteoconductivity, nontoxicity and noninflammatory. With its unique properties, it is found applications in repairing of bone and as coatings for metallic prostheses. Bone consists of hydroxyapatite crystals as the major component of the mineral phase and collagen as the major component of the organic phase. By the inspiration of bone structure, hydroxyapatite-polymer composites have been drawing attention for years. In this work, hydroxyapatite was participated with gelatin which is similar to collagen. Spray dryer is used as drying medium to investigate the effect of different weight gelatin ratios on powder. Moreover, in-vitro studies were conducted to investigate their bioactivity on a selected sample. The results showed that these materials may be suitable for bio-applications.
Nature and distribution of soil phosphorus as revealed by a sequential extraction method followed by 31P nuclear magnetic resonance analysis

SUMMARY Soil samples from long-term plots annually fertilized with superphosphate since 1952 and also unfertilized (control) plots of an irrigated and intensively grazed pasture in Canterbury, New Zealand, were subjected to a sequential extraction procedure followed by 31P nuclear magnetic resonance (NMR) analysis of the soil phosphorus (P) forms present. Overall, 80% of the total organic P (as determined by ignition) was removed from the soil by the sequential extraction procedure. Most of the organic P (90%) detected by NMR was in the monoester fraction. Small quantities of diester and pyrophosphate were also found. Choline phosphate constituted a significant proportion (18–25%) of the monoester P in the acetylacetone and 0.5 M NaOH extracts. Long-term superphosphate additions resulted in almost all of the P accumulated in the monoester P fraction (up to 99%).
ECMELLA: successful rescue cardiopulmonary support in post-coronary artery bypass graft cardiogenic shock with cardiac arrest—case report

Abstract Background Cardiogenic shock is the main cause of death in hospitalized patients with acute coronary syndromes, with a high mortality rate. The management of graft thrombosis after coronary artery bypass graft (CABG) surgery is challenging and the best revascularization strategy is not well defined. In patients who develop cardiac arrest due to graft thrombosis, the benefits of mechanical support during advanced cardiac life support are uncertain. Rescue extracorporeal cardiac bypass resuscitation has been used in the context of cardiopulmonary arrest, with survival rates of around 34.7% of which 28.5% with good neurological outcome. Case summary We present here the case of a patient who developed cardiogenic shock after CABG graft occlusion. The patient suffered refractory cardiac arrest during percutaneous revascularization and received rescue cardiopulmonary support. Revascularization was achieved and there was a successful resuscitation with the placement of venous-arterial extracorporeal membrane oxygenation (VA-ECMO) and an Impella CP device. After a 29-day hospitalization the patient was discharged with no neurological sequelae. Discussion Although there is limited evidence of the benefit of a combined use of mechanical support (VA-ECMO with other mechanical devices) in the management of cardiogenic shock and cardiac arrest following CABG surgery, there seems to be a lower mortality with this approach, and possibly more favourable neurological outcomes. Further research is needed to elucidate the advantages of Impella vs. intra-aortic balloon pump combined with VA-ECMO in such patients.
Trusting the crowd: Effects of crowdfunding on venture capital syndicates

ABSTRACT We assess whether and how crowdfunding influences follow-up financing through syndicated venture capital. Drawing on signaling theory and the syndication literature, our overarching empirical finding is that crowdfunding influences different dimensions of the venture capital syndication process. First, ventures that used crowdfunding have a lower likelihood to be financed by a syndicated investment. Second, a crowdfunding campaign facilitates smaller but more international syndicates, while investment experience appears to be incidental. Overall, our results show that a crowdfunding campaign can mitigate information asymmetries between a venture capitalist and a new venture, reducing the need to form syndicates.
The high-throughput screening system for inhibitor Mycobacterium tuberculosis compounds based on ATP hydrolysis activity of recombinant protein ClpC1

The global Tuberculosis (TB) rate continues to increase by 1% per year with the widespread of drug-resistant TB. Therefore, the development and research to find new anti-TB drugs are becoming an extremely urgent mission. To be able to screen lead anti-tuberculosis drugs, currently, researchers have to carry out directly on the cells of Mycobacterium tuberculosis and to be performed in bio-security facilities level 3 or 4, to prevent infection from pathogens. However, our results demonstrated that the screening of anti-TB drug candidates can be implemented in biosecurity facilities level 1 laboratory with the Escherichia coli cell extraction and recombinant ClpC1 protein an integral part of the Mycobacterium tuberculosis genome. We focused on the ATP hydrolysis activity of ClpC1 to create a specific research direction for the high-throughput antituberculosis drug screening system. ClpC1 protein was overexpressed and purified with functionally characterized (93.5 kDa). The steady-state growth of recombinant ClpC1 protein in Luria-Bertani (LB) broth High Salt medium was maintained and stabilized after extraction. The determined ATPase activity of ClpC1 was performed by measuring the released phosphate from the reaction. Ecumicin was chosen to be a control compound with expected ATP hydrolysis activities (Hill coefficient = 1,19 ± 0,217; Kd value = 0,52 ± 0,275). We tested this high throughput screening system with ten anti-TB drugs to evaluate the effectiveness of our screening system. Based on these results, we built a complete high-throughput screening system anti-tuberculosis drug safety and quickly.