Miracle-dz/UniFAR-FTUs huggingface dataset:
A Phase II Study of Denileukin Diftitox (Ontak®) with CHOP Chemotherapy in Patients with Newly-Diagnosed Aggressive T-Cell Lymphomas, the CONCEPT Trial: Interim Analysis.

Denileukin diftitox, a genetically engineered fusion protein comprised of the enzymatically active domain of diphtheria toxin and the full length sequence of human interleukin-2 (IL-2) that targets malignancies expressing the IL-2 receptor, is approved for cutaneous T-cell lymphoma and has demonstrated a 48% objective response rate in relapsed/refractory PTCL. Because denileukin diftitox is not myelosuppressive and induces apoptosis by inhibition of protein synthesis, a mechanism of action non-cross-resistant with chemotherapy, we evaluated the efficacy and safety of the combination of denileukin diftitox plus CHOP in newly diagnosed aggressive T-cell lymphomas. In this multicenter Phase II study, patients (pts) with aggressive T-cell histologies according to REAL classification were eligible. Pts were required to have absolute neutrophil count ≥1000, platelets ≥50,000, adequate renal and hepatic function with serum albumin ≥3.0 g/dL, and LVEF ≥50%. Denileukin diftitox was given by IV infusion at 18 mcg/kg/day on Days 1 and 2 of each cycle, followed by CHOP chemotherapy on Day 3, and G-CSF support starting Day 4 of each cycle. Cycles were administered every 3 weeks for up to 6 cycles. Restaging evaluation of response is performed after every 2 cycles. The study objective for efficacy is to achieve an overall response rate (CR+PR) of 70%. Twenty-one patients (76% PTCLnos) have been enrolled to date, with a median age of 56 (range 40–80), 10 male, and 11 female. Six patients are not evaluable for response; one discontinued therapy during Cycle 1 due to a hypersensitivity reaction, and 5 are too early to evaluate (1 cycle of therapy given). For the 15 evaluable patients, the overall response rate is 87% with 9 CR or CRu (60%), 4 PR (27%) and 1 each for stable and progressive disease (see Table below). Four of 13 responders (31%) have progressed, with duration of response ranging from 1.5 to 5.9 months. Toxicities have generally been grade 1–2, were transient, and caused few treatment delays. The most common adverse events have been edema (27%), elevated transaminases (20%), and hypoalbuminemia (14%). Only two Grade 4 toxicities were noted (one each of neutropenia and deniluekin diftitox infusion-related allergic reaction). This is the first trial to report on the use of ONTAK in combination with chemotherapy. The novel combination of denileukin diftitox and CHOP appears to be clinically active, and is well tolerated with no unexpected, new, or overlapping toxicities. Pt accrual is ongoing.
Effect of Moringa Oleifera on Lipid Profile in Rats

Background: Coronary heart disease, stroke, atherosclerosis and hyperlipidemia are primary causes of death worldwide. Moringa Oleifera tree was used as a health supplement introduced to Africa from India. Its leaves have various biological activities, including hypolipidemic effect. Objective(s): The aim of present study was to assess the effect of Moringa Oleifera consumption on lipid profile and histopathology of the liver in hyperlipidemic rats. Methods: A total of 50 male albino rats were divided into five equal groups. Group I was left as control and fed on standard diet only. Group II was fed on standard diet and orally injected with 400 mg/kg of rat body weight extract of Moringa Oleifera. Hyperlipidemia was induced in the remaining 30 rats by feeding an atherogenic diet for four weeks. Group III was fed on atherogenic diet only. Group IV was fed on atherogenic diet and orally injected with 400 mg/kg of rat body weight extract of Moringa Oleifera. Group V was fed on atherogenic diet with 2mg/kg of rat body weight Atorvastatin drug. Lipid profile of rat blood was measured including total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), and very low density lipoprotein (VLDL). Liver tissue was evaluated by carrying out histopathological examination. Results: The rats fed on Moringa Oleifera showed a significant decrease in total cholesterol and LDL by 26.8% and 40.6% respectively compared to baseline values after 4 weeks. Although VLDL and TG showed slight increase by 5.6% and 5.1% respectively, they were still within the normal range. Otherwise, there was a significant increase in LDL, VLDL, TC, and total TG levels in rats fed on atherogenic diet only by 17.13%, 195.4%, 29.2%, and 193% respectively compared to baseline values after 4 weeks. Atorvastatin drug affected the HDL level, as it increased by 16.4% % 28% from baseline after two and four weeks respectively. Atorvastatin and Moringa Oleifera decreased VLDL level by 53.9% & 36.5% respectively when compared to rats fed on atherogenic diet. Conclusion: Moringa Oleifera was comparable to hypolipidemic medication (Atorvastatin) in improving the lipid profile of rats fed on atherogenic diet. Moringa Oleifera intake is more effective in prevention than in treatment of hyperlipidemia. Keywords: lipid profile, atherosclerosis, Moringa Oleifera, atherogenic diet, atorvastatin.
Tonality estimation in electronic dance music: a computational and musically informed examination

This dissertation revolves around the task of computational key estimation in electronic dance music, upon which three interrelated operations are performed. First, I attempt to detect possible misconceptions within the task, which is typically accomplished with a tonal vocabulary overly centred in Western classical tonality, reduced to a binary major/minor model which might not accomodate popular music styles. Second, I present a study of tonal practises in electronic dance music, developed hand in hand with the curation of a corpus of over 2,000 audio excerpts, including various subgenres and degrees of complexity. Based on this corpus, I propose the creation of more open-ended key labels, accounting for other modal practises and ambivalent tonal configurations. Last, I describe my own key finding methods, adapting existing models to the musical idiosyncrasies and tonal distributions of electronic dance music, with new statistical key profiles derived from the newly created corpus.
A Method of Web Information Extraction Based on Building Different Sub Trees

When extracting Web information, most researchers mixed the structure labels of DOM Tree with the text content. For solving this problem, we put forward a method of Web Information automatic extraction. Firstly, we get the set of DOM sub trees by partitioning the DOM Tree of the Web Page. Secondly, the nodes of all DOM sub trees are set the corresponding weights by the method this paper proposes. Based on this method, we get each set of different sub trees by comparing with the DOM sub trees which come from two the same data source and belongs to the same category. Thirdly, we get the data zone which contains the extracted information by computing the similarity of every two DOM sub trees in the set of different sub trees. Finally, the node path of every DOM sub tree in the data zone will be taken as the extraction rules which will be used to automatically extract the information from the new Web page of the same category. The experiment demonstrates that there are higher precision rate and recall rate. Meanwhile this method can save the time which the users spend on filtering the information.
A brief introduction of National Standard of the People's Republic of China "Mass Center of Chinese Adults"

This standard applies the CT (computerized tomography) method to measure the inertia parameters of Chinese adults. Male and female Chinese adults were chosen as samples to take computerized tomograms from, and 82 items of body-shape indexes were measured. The densities of 19 kinds of tissues and organs were also measured, and 16 items of human body segment parameters were obtained. In addition, the regression equations for the calculation of the inertia parameters of the human body were set up. Based on the data in the Database of Chinese Adults, the National Standard GB/T 17254-1988 ("Mass Center of Chinese Adults") has been prepared. Rubber dummies have been made in order to perform simulation experiments of human body movements. A new type of helmet was developed to improve the stress conditions of the neck, and a rational, simplified model of Chinese youths has been made. These achievements can be widely used in national defense, industry, sports, and many other fields.
L’apocalypse dans les représentations de l’épidémie du VIH/sida : du religieux au médiatique

Depuis les annees 1980, l’epidemie du VIH/sida, a cause de sa gravite, a contribue a des representations sociales et des interpretations dont certaines reprennent le theme de l’apocalypse. Cet article cerne cette notion dans trois ensembles de discours. Des mouvements religieux ont repris cette idee dans une perspective fondamentaliste, mais d’autres courants theologiques critiquent cet usage et proposent d’autres interpretations. Les textes philosophiques en font un emploi plus profane et hyperbolique pour signifier l’ampleur catastrophique de l’epidemie, une perspective remise aussi en question par des intellectuels critiques qui produisent des contre discours plus conformes a une vision immanente de l’infection. Les medias ont recours repetitivement a cette notion pour souligner la dimension sensationnaliste du VIH/sida, malgre les progres pharmacologiques susceptibles d’entrainer un effacement de ce type de references.
Vers un modèle de l'alignement e-business de l'entreprise

La plupart des travaux de recherche concernant l'e-business presentent une methodologie, mesurent la predisposition des entreprises ou evaluent les consequences en terme de gestion.Cette recherche vise a apporter un modele d'analyse des strategies e-business, a partir de la perspective de l'alignement strategique.Pour ce faire, a partir de la litterature en Systemes d'Information (SI) traitant de l'alignement et de l'information recueillie dans 11 entretiens semi-directifs centres menes aupres de dirigeants et responsables e-business des principales entreprises du secteur du tourisme francais, un certain nombre de variables ont ete retenues.Celles-ci permettent alors de construire un modele d'alignement e-business de l'entreprise.
African youth hungry for connectivity

In a tiny sweltering tin-roofed shack tucked inside one of Mogadishu’s bullet-riddled neighbourhoods, two brothers, Ali Hassan and Mustafa Yare, sit hunched over one of eight humming desktop computers. Together they show Nasteexo Cadey, a young veiled student at Mogadishu University, how to set up her Facebook account, browse YouTube videos and check her e-mail.
Neural analysis of bovine ovaries ultrasound images in the identification process of the corpus luteum: preliminary study

The aim of the paper is to present the neural image analysis as a method useful for identifying the position of the corpus luteum of domestic bovine on digital USG (UltraSonoGraphy) images. Corpus luteum is a transient endocrine gland that develops after ovulation from the follicle secretory cells. The main function of the corpus luteum is the production of progesterone, which regulates many reproductive functions. In the presented studies, identification of the corpus luteum was carried out on the basis of information contained in ultrasound digital images. Position of the corpus luteum was considered in two locations: on the surface of the ovary and within its parenchymal. Prior to the classification, the ultrasound images have been processed using a sharpening filter - unsharp mask. To generate a classification model, a Neural Networks module implemented in the STATISTICA was used. Five representative parameters describing the ultrasound image were used as learner variables. On the output of the artificial neural network was generated information about the location of the corpus luteum. Results of this study indicate that neural image analysis may be a useful instrument for identifying the bovine corpus luteum in the context of its location on the surface or in the ovarian parenchyma. Best-generated artificial neural network model was the structure of MLP (Multi Layer Perceptron) 5:5-364- 285-1:1.
Clinical scores used for the prediction of negative events in patients undergoing catheter ablation for atrial fibrillation

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in adults. Catheter ablation (CA) is one of the most important management strategies to reduce AF burden and AF‐associated complications. In order to stratify the risk of adverse events and to predict treatment success in AF patients undergoing CA, several risk stratification scores had been developed during the last decade. The aim of this review is to provide an overview of the most important clinical risk scores predicting rhythm outcomes, electro‐anatomical substrate and mortality in AF.
Single-dose antibiotic prophylaxis in women undergoing vaginal hysterectomy.

: One hundred thirty-five patients undergoing vaginal hysterectomy were randomly assigned to one of three regimens of prophylactic antibiotics. There was no statistically significant difference among the three groups in the incidence of postoperative pelvic cellulitis, fever index, or duration of hospitalization. A single preoperative dose of cefazolin was as effective as three perioperative doses of cefazolin or a single dose of cefonicid in preventing postoperative infectious morbidity.
Spinal Pain and Occupational Disability: A Cohort Study of British Apache AH Mk1 Pilots

Abstract : Spinal pain (principally cervical and lumbar) has been identified for many years as an exceedingly pervasive problem among the rotary-wing community. A ten-year collaborative longitudinal occupational health survey was undertaken to study British Army helicopter pilots. This coincided with the newly-released to service U.K. Apache Mk 1 attack helicopter. Two cohorts, Apache pilots (AP, n=63) and non-Apache pilots (NAP, n=135), were followed longitudinally by interval questionnaires regarding spinal pain characteristics and associated occupational disability. Despite a newer generation aircraft and lighter helmet for the Apache, there were no appreciable differences of notable consequence identified between the two cohorts. The study was subject to a number of limitations, most notably poor response numbers in later iterations of follow-up. Nonetheless, the data illustrate that neck and back pain remain prominent maladies among these cohorts with notable percentages of both groups reporting flight-related pain and associated disability and flying restriction.
Formas farmacéuticas y microencapsulación para la administración oral de probióticos

This thesis has been developed within the Andalusian Research Group CTS-205 ? Practical pharmaceutics? in collaboration with NIZO Food Research (Ede, The Netherland). One of the research lines of the group CTS-205 is the development of different dosage forms and particles for the administration of probiotics. Specifically, this thesis has been focused in the preparation and characterization of microparticles for the protection of Lactobacillus fermentum CECT 5716 and Lactobacillus plantarum WCSF1. Furthermore, preparation of tablets for the administration of L. fermentum CECT5716 was also performed. With these aims, different encapsulation technologies used with probiotics were firstly reviewed. Then, internal gelation technology was selected for the microencapsulation of L. fermentum CECT 5716. Results show that these particles were able to partially protect bacteria during one month at 4 oC. In the case of L. plantarum WCSF1, spray dried technology using different carriers was tested. The protection provide by the carriers was insufficient. However the selected food matrix (infant formula) seems to be adequate as a result of its low moisture content. Concerning oral solid dosage forms, different gastro-resistant tablets were developed. The selected material was compatible with probiotic. Viability of probiotics after technological process was 10% which allow to obtain tablets with 109 ufc, concentration that meets the objective for this kind of pharmaceutical forms. Tablets also meet the quality criteria required by the United States Pharmacopeia and Spanish Pharmacopeia referring to friability and disintegration test. Protection of probiotics through passage to the stomach and delivery of probiotic in the intestine were verified. The best viability after simulated stomach pH was for Eudragit® L100- sodium alginate tablets. These tablets were found to be stable over a 6 months period when stored at 4oC. However, at room temperature tablets started to lose viability after 3 months. As a whole, the results of the present work provide evidence that probiotics can be protected by microencapsulation to be included in food and pharmaceutical matrices, but not all microencapsulation techniques are suitable. Internal gelation with alginate and starch has shown to be suitable, at least for L.fermentum CECT5716. Controlled-release tablets are suitable pharmaceutical forms for the administration of probiotics. Further studies are needed to analyze the behavior of microencapsulated probiotics into food matrices and to prove the effects of these formulations in vivo.
A Review of EEG Signal Classifier Based on Deep Learning

Electroencephalogram (EEG) signal recognition is an active research topic in the field of artificial intelligence and has been gaining extensive attention and engineering communities. This technology is an important basis of human computer interaction and many other fields. The deep learning theory has made remarkable achievements on feature extraction and gradually extended to the time sequences of EEG research. This paper reviews the traditional feature extraction of EEG recognition and discuss the traditional classification methods of EEG recognition such as linear discriminant analysis (LDA), support vector machine (SVM) and long short time memory (LSTM). Finally, this paper summarizes advantages and disadvantages of these methods. Through the feature extraction by the wavelet transform and LSTM classification, it has achieved 98% accuracy and verified that LSTM is suitable for EEG signal with time sequence feature.
Indoor Navigation and Location-Based Services for Persons with Motor Limitations

Persons with motor limitations constitute a group-challenge when building indoor navigation and Location-Based Services (LBS). The authors present here the systematic approach they have developed that has to be taken into account in the user needs analysis of persons with motor disabilities when an advanced system for indoor navigation and LBS is designed. In the first part the authors present a stepby-step and detailed methodology about the extraction of the user requirements’ knowledge in order to develop an indoor navigation and LBS system that provides adequate and usable output to persons with motor limitations. In the second part, after an overview of the existing indoor LBS, the authors present the development of the MNISIKLIS system giving emphasis on the User Interface designed after following the knowledge derived from the first part.
Mixed Infection with Plasmodium falciparum and Plasmodium ovale in a Returned Traveller: the First Case in Korea

Mixed-species malaria infections are often unrecognized or underestimated. We hereby report the first described case of mixed infection with Plasmodium falciparum and Plasmodium ovale malaria in a returned traveller in Korea. In August 2016, a 25-year-old returned traveller from Cameroon and Democratic Republic of Congo presented with fever. He was diagnosed as P. falciparum malaria and successfully treated with artesunate. And 5 weeks after the completion of treatment, he presented with fever and diagnosed as P. ovale infection. P. ovale infection is a rare cause of malaria and often shows delayed presentation due to its dormant liver stage as hypnozoites. At re-presentation, the immunochromatographic test and microscopic examinations of our patient did not reveal P. ovale, which was only detected via polymerase chain reaction (PCR) assay. This case highlights the importance of considering malaria infection even in persons who have previously received malaria treatment. It also shows the usefulness of PCR testing for diagnosing P. ovale infections, which often present with a low level of parasitaemia.
Barriers to Implementation of Patient Safety Systems in Healthcare Institutions: Leadership and Policy Implications

The objective of this study was to identify barriers to implementation of patient safety systems in healthcare institutions to serve as baseline data for healthcare senior leadership and policy makers. The Delphi method for gaining consensus from a group of experts and forecasting significant issues in the field of the Delphi panel expertise was used. Data collection included a series of questionnaires. Twenty-three experts in healthcare quality and healthcare systems approach, representing 18 U.S. states, participated in the survey rounds. The first iteration of the survey returned a variety of barriers to implementing patient safety systems in healthcare institutions. All suggested barriers were grouped thematically, and 29 different barriers were formed. During the second and third survey rounds, the Delphi panelists were asked to rank the importance of each barrier on a 4-point Likert scale. Addressing the identified "top 7" barriers to implementation of patient safety systems carries great potential for enhancing the implementation of safety healthcare systems. Importantly, all "top 7" barriers are systemic in nature. Thus, the efforts of individual institutions, while very important, will be less successful than a broader systemic approach across the U.S. healthcare system. This study is significant because the results are expected to assist healthcare administrators and healthcare policy makers in eliminating barriers to healthcare quality and improving patient safety.
OS Support for Improving Data Locality on CC-NUMA Compute Servers

The dominant architecture for the next generation of cache-coherent shared-memory multiprocessors is CC-NUMA (cache-coherent non-uniform memory architecture). These machines are attractive as compute servers, because they provide transparent access to local and remote memory. However, the access latency to remote memory is 3 - 5 times the latency to local memory. Given the large remote access latencies, data locality is potentially the most important performance issue. In compute-server workloads, when moving processes between nodes for load balancing, to maintain data locality the OS needs to do page-migration and page-replication. Through trace-analysis and actual runs of realistic workloads, we study the potential improvements in performance provided by OS supported dynamic migration and replication. Analyzing our kernel-based implementation of the policy, we provide a detailed breakdown of the costs and point out the functions using the most time. We study alternatives to using full-cache miss information to drive the policy, and show that sampling of cache misses can be used to reduce cost without compromising performance, and that TLB misses are inconsistent as an approximation for cache misses. Finally, our workload runs show that OS supported dynamic page-migration and page-replication can substantially increase performance, as much as 29%, in some workloads.