Miracle-dz/UniFAR-FTUs huggingface dataset:
Articulating identities

One symptom of individualism in liquid modernity is the search for `identity'. Using the five theoretically discrete articles in this special issue as both a `rich' discursive resource and a point of departure, we develop a supplementary reading of the narratives which appear to inform identity research. We suggest that, while social agents in pursuit of `identity' draw on a cacophony of discursive sources, it is the varieties of `self—other' talk which emerge as the critical ingredient in processes of identity formation. The dualities that all such self—other talk articulate can be seen as discursive reflections of the more fundamental relationship between the individual and sociality. In turn, this is seen to refract one of the persistent problems of organizational analysis: the agency—structure issue. In addition, while we argue that deploying a discursive perspective to analyze identity work offers distinctive insights, such an approach carries with it an epistemological consequence. For what the articles also indicate is that in any attempt to delineate the `identity of identities', researchers need to be aware of not only the reflexivity displayed by social actors constructing `identity' but also of their own role in `re-authoring' such scripts. We briefly explore the implications of this for identity theory and organizational analysis more generally.
Abnormal Glucose Counterregulation in Insulin-dependent Diabetes Mellitus: Interaction of Anti-Insulin Antibodies and Impaired Glucagon and Epinephrine Secretion

To evaluate the roles of counterregulatory hormones and insulin antibodies in the impairment of plasma glucose recovery from hypoglycemia in diabetes mellitus, and to assess the relationship between the glucagon response and duration of the disease, 21 insulin-dependent diabetic patients and 10 nondiabetic subjects were studied. The diabetics consisted of 5 patients with recent onset of diabetes (< 1 mo); 11 with 2.6 ± 0.3 (mean ± SEM) yr duration of diabetes, 5 of whom had insulin antibodies; and 5 patients with long-term diabetes (21 ± 3 yr), insulin antibodies, and autonomic neuropathy. During insulin-induced hypoglycemia (28 mU/m2 × min for 60 min) in patients with recent-onset diabetes, plasma free insulin, glucose, and counterregulatory hormone concentrations did not differ from those of nondiabetic subjects. In patients with insulin antibodies, the disappearance of insulin after insulin infusion was delayed, and both restitution of normoglycemia and plasma glucagon response were blunted compared with patients without antibodies. When glucagon was infused (80–130 ng/m2 × min) during hypoglycemia in diabetics with impaired glucagon responses in order to simulate normal glucagon responses, plasma glucose recovery was normalized in patients without antibodies but not in those with antibodies. In patients with long-standing diabetes, restitution of normoglycemia was further impaired and this was associated with an absent plasma glucagon response and a diminished plasma epinephrine response. Plasma glucagon responses to hypoglycemia were inversely correlated to the duration of diabetes (r = −0.943; P < 0.0005). It is concluded that impaired A-cell secretion is the predominant mechanism for the delayed glucose recovery after hypoglycemia in diabetic patients without insulin antibodies and normal epinephrine responses. Slowed disappearance of insulin due to the presence of insulin antibodies further delays the restoration of normoglycemia. Patients with long-standing diabetes and autonomic neuropathy exhibit decreased epinephrine secretion, which leads to an additional retardation of glucose recovery. Since plasma glucagon and epinephrine responses to hypoglycemia were normal at the onset of diabetes but diminished in long-term diabetes, it appears that the impaired glucagon and epinephrine responses to hypoglycemia are acquired defects that develop subsequent to B-cell failure.
P2P InterCoop: P2P-based Decentralised Inter-organizational Cooperation - Motivations and Requirements

As the global marketplace becomes more and more competitive, corporations often need to cooperate in order to utilize the best of their resources for achieving their common business goals. This kind of collaboration gives a corporation a possibility to use the capabilities of their business partners that they do not currently have. In addition, mergers, acquisitions, alliances, and market demands are some of the reasons why companies have distributed work across geographically separated sites. Although P2P systems are emerging as a new form of distributed architecture, the centralized architecture of the existing collaborative environments has major drawbacks. This paper presents a new architecture called P2P InterCoop for supporting distributed cooperative work; it identifies basic requirements, advantages and limitations.
Association of low serum total cholesterol with major depression and suicide

Background It has been suggested that low serum total cholesterol is associated with an increased risk of suicide. Aims To study the association between serum total cholesterol, depression and suicide using versatile, prospective data. Method A total of 29 133 men aged 50–69 years were followed up for 5–8 years. Baseline blood samples were analysed for serum total and high-density lipoprotein cholesterol concentrations. Self-reported depression was recorded, data on hospital treatments due to depressive disorders were derived from the National Hospital Discharge Register and deaths from suicide were identified from death certificates. Results Low serum total cholesterol was associated with low mood and subsequently a heightened risk of hospital treatment due to major depressive disorder and of death from suicide. Conclusions Our results suggest that low serum total cholesterol appears to be associated with low mood and thus to predict its serious consequences.
Understanding Diffusions of Corporate Sustainability Standards Through Sub-Supplier Management in the Food Supply Chain

The food industry and its supply chains have significant sustainability implications. Effective supply chain management requires careful consideration of multiple tiers of partners, especially with respect to sustainability issues. Firms increasingly approach their sub-suppliers to drive compliance with social and environmental efforts. A number of complexities make sub- supplier management more difficult than direct supplier management. The literature has not investigated from either a sustainability or standards perspective the critical success factors for firms' sub-supplier management. Using data and information from a one-year field study in two food supply chains, our research identified 14 critical success factors (CSF) that potentially influence the success of the sub-supplier management outcome of sub-suppliers' compliance with corporate sustainability standards (CSS). The identified CSF can be classified into (1) focal firm-related, (2) relationship-related, (3) supply chain partner-related, and (4) context-related CSF. We expand on the theory of critical success factors by expanding the theory to sustainability and sub-supplier management. For each CSF we provide a foundational definition and analyze them with respect to existent literature. CSF's unique importance to sub-supplier management success was highlighted and exemplified by field study insights from practitioners. Respective research avenues are highlighted. [http://www.clarku. edu/departments/marsh/news/WP2012-25.pdf Link]
Does The Implementation Of ERP Improve The Quality Of Accounting Information? Evidence From Chinese A-Share Listed Manufacturing Firms

Using the data of Chinese A-share listed manufacturing firms, the study explores the influence of ERP implementation on accounting information quality from reliability and relevance. Also, the study verifies the difference of the influence in firms which have different sizes and different ownership types. Compared with the firms not implementing ERP, accounting information quality of the firms implementing ERP improves significantly. In addition, the positive influence differs in firms of different sizes and different ownership types. In large-sized firms, ERP implementation has stronger influence on reliability of accounting information. In non-state-owned firms, ERP implementation has stronger influence on accounting information quality in respect to reliability and relevance. Our study supplies the new evidence to gauge the impact of ERP implementation on accounting information quality in an emerging economy context.
HYPOTHERMIA INDUCES INTERLEUKIN‐10 AND ATTENUATES INJURY IN THE LUNGS OF ENDOTOXEMIC RATS

&NA; We recently reported that hypothermia protects against intrapulmonary nitric oxide overproduction and nitric oxide‐mediated lung injury in endotoxemic rats. Few studies have been performed to investigate whether hypothermia reduces inflammation by affecting favorable changes in chemokine and pro‐and anti‐inflammatory cytokine profiles. In this study, we tested the hypothesis that hypothermia decreases concentrations of growth‐related oncogene/cytokine‐induced neutrophil chemoattractant‐1 (GRO/CINC‐1), interleukin (IL)‐1&bgr;, IL‐6, and myeloperoxidase and increases concentration of IL‐10 in the lungs endotoxemic rats. Twelve rats were anesthetized and randomized to treatment with either hypothermia (T = 18‐24°C; n = 6) or normothermia (T = 36‐38°C, n = 6). Endotoxin (15 mg/kg of Escherichia coli lipopolysaccharide) was administered intravascularly and lung tissue was harvested 150 min later. Three additional rats were sham instrumented and maintained as normothermic but not given endotoxin. Hematoxylin & eosin staining was performed for qualitative inspection of tissues. Quantitative analyses of lung homogenates were performed using enzyme‐linked immunosorbent assays for IL‐1&bgr;, IL‐6, IL‐10, and GRO/CINC‐1. Myeloperoxidase concentrations were determined using a colorimetric assay. Hypothermia attenuated the induction of intrapulmonary IL‐1&bgr; (P < 0.05), IL‐6 (P < 0.05), GRO/CINC‐1 (P < 0.05), and myeloperoxidase (P < 0.05) caused by endotoxin. Inspection of the lungs revealed that hypothermia similarly attenuated histological signs of injury, such as interstitial edema and neutrophil accumulation. Hypothermia increased the intrapulmonary concentration of IL‐10 more than 3‐fold over that measured in the normothermia (endotoxinexposed) group (P < 0.05). Hypothermia inhibits neutrophil recruitment in the lungs of endotoxemic rats in part by decreasing proinflammatory cytokine expression. Additionally, hypothermia induces intrapulmonary IL‐10 expression. Further studies are needed to investigate whether IL‐10 mediates the anti‐inflammatory effects of hypothermia.
The implementation of kangaroo mother care and nurses’ perspective of barriers in Iranian’ NICUs

Background: Kangaroo mother care (KMC) is the most implementation intervention in caring of the infants, as in this method, both the mothers and infants are cared. The World Health Organization recommends implementation of KMC for all infants. However, there are some barriers in the way of its application. The purpose of this study was evaluation of the practical application of KMC and nurses' perspective about its implantation barriers in the neonatal intensive care units (NICUs) in Iran. Materials and Methods: The descriptive study was conducted on 96 infants and 80 nurses working in the NICUs of two university hospitals in Isfahan, Iran. Data were collected by a two-section questionnaire and analyzed by t-test through SPSS 14. Results: Study findings indicated that mean weight and age of the infants with KMC were 1510 g and 32 weeks, respectively. KMC was implantation for 32 min in a day. From nurses' perspective, mother-related barriers were the main barriers in the implantation of KMC as mothers were not present by their infants. Another barrier was the mothers' fear of touching their infants. In the domain of organizational barriers, physician's order was found to be the most important barrier in application of KMC. Conclusions: Identifying barriers in implantation of KMC is essential to support the mothers. Regarding mother-related barriers, organizational barriers, and the need for a physician's order for implementation of KMC, policy makers must provide facilities and equipment for applying KMC practice for mothers and improve the protocol of KMC in the NICU.
A multiagent filovirus DNA vaccine delivered by intramuscular electroporation completely protects mice from ebola and Marburg virus challenge

We evaluated the immunogenicity and protective efficacy of DNA vaccines expressing the codon-optimized envelope glycoprotein genes of Zaire ebolavirus, Sudan ebolavirus, and Marburg marburgvirus (Musoke and Ravn). Intramuscular or intradermal delivery of the vaccines in BALB/c mice was performed using the TriGrid™ electroporation device. Mice that received DNA vaccines against the individual viruses developed robust glycoprotein-specific antibody titers as determined by ELISA and survived lethal viral challenge with no display of clinical signs of infection. Survival curve analysis revealed there was a statistically significant increase in survival compared to the control groups for both the Ebola and Ravn virus challenges. These data suggest that further analysis of the immune responses generated in the mice and additional protection studies in nonhuman primates are warranted.
Matrix metalloproteinases with gelatinolytic activity induced by Paracoccidioides brasiliensis infection

Matrix metalloproteinases (MMPs) modulate extracellular matrix turnover, inflammation and immunity. We studied MMP‐9 and MMP‐2 in experimental paracoccidioidomycosis. At 15 and 120 days after infection (DAI) with virulent Paracoccidioides brasiliensis, MMP‐9 was positive by immunohistochemistry in multinucleated giant cells, in mononuclear cells with macrophage and lymphocyte morphologies and also in fungal cells in the lesions of susceptible and resistant mice. Using gelatin zymography, pro‐ and active MMP‐9 and active MMP‐2 were detected in all infected mice, but not in controls. Gelatinolytic activity was not observed in P. brasiliensis extracts. Semiquantitative analysis of gelatinolytic activities revealed weak or absent MMP‐2 and strong MMP‐9 activity in both mouse strains at 15 DAI, declining at 120 DAI. Avirulent P. brasiliensis‐infected mice had residual lesions with MMP‐9‐positive pseudoxantomatous macrophages, but no gelatinase activity at 120 DAI. Our findings demonstrate the induction of MMPs, particularly MMP‐9, in experimental paracoccidioidomycosis, suggesting a possible influence in the pattern of granulomas and in fungal dissemination.
Loss of Cell Cycle Checkpoint Control in Drosophila Rfc4 Mutants

ABSTRACT Two alleles of the Drosophila melanogaster Rfc4(DmRfc4) gene, which encodes subunit 4 of the replication factor C (RFC) complex, cause striking defects in mitotic chromosome cohesion and condensation. These mutations produce larval phenotypes consistent with a role in DNA replication but also result in mitotic chromosomal defects appearing either as premature chromosome condensation-like or precocious sister chromatid separation figures. Though the DmRFC4 protein localizes to all replicating nuclei, it is dispersed from chromatin in mitosis. Thus the mitotic defects appear not to be the result of a direct role for RFC4 in chromosome structure. We also show that the mitotic defects in these twoDmRfc4 alleles are the result of aberrant checkpoint control in response to DNA replication inhibition or damage to chromosomes. Not all surveillance function is compromised in these mutants, as the kinetochore attachment checkpoint is operative. Intriguingly, metaphase delay is frequently observed with the more severe of the two alleles, indicating that subsequent chromosome segregation may be inhibited. This is the first demonstration that subunit 4 of RFC functions in checkpoint control in any organism, and our findings additionally emphasize the conserved nature of RFC's involvement in checkpoint control in multicellular eukaryotes.
Early management of endotoxemia using the endotoxin activity assay and polymyxin B-based hemoperfusion.

BACKGROUND We evaluated the ability of the endotoxin activity (EA) assay to determine the need for early intervention for endotoxemia using polymyxin B-based hemoperfusion (PMX-DHP) on septic patients. METHODS Twenty-four patients were enrolled. Eleven patients had a high EA level (> or = 0.6) and were treated with PMX-DHP every 24 h until the EA level was low ( < 0.4). The remaining 13 patients had EA levels < 0.60 and received standard therapy only. RESULTS Two PMX-DHP treatments were performed on 4 patients, three treatments on 6 patients and four treatments on 1 patient. After the therapy, mean arterial pressure increased (69.45 to 84.09 mm Hg; p < 0.01), heart rate decreased (Ill.73 to77.91 beats/min; p < 0.01), white blood cell count decreased (18,380 to 9,550 cells/mm(3); p < 0.01), the PMN (polymorphonuclear) percentage decreased (88.45 to 67.82%; p < 0.01) and PaO(2)/FiO(2) increased (275 to 308.09; p < 0.01). All 24 patients survived to the 28-day follow-up. CONCLUSION The EA assay can identify patients eligible for PMX-DHP treatment and aids its therapeutic dosing.
Histone, a suppressor of chromosomal RNA synthesis.

We have previously reported(1,2) that chromatin isolated from pea embryos possesses the ability to carry out the DNA-dependent synthesis of RNA from the four riboside triphosphates. (3) The present paper concerns the roles in such synthesis of the several components of chromatin. It will be shown that the DNA of pea embryo chromatin is present in at least two forms, namely, as DNA itself and as DNA bound in nucleohistone complex. It will be further shown that DNA fully complexed with histone is inactive in the support of DNA-dependent RNA synthesis.
Case Method: Entity Relationship Modelling

From the Publisher: powerful technique of entity relationship modelling from this definitive guide. In a lucid instructional style, Richard Barker shows how the data modelling technique can be applied to develop high-quality, integrated information systems. Special features of the book include: a wealth of realistic examples illustrating the technique in practice detailed appendices highlighting the key topics including data normalization, CASE tool support, data administration and database design a definitive glossary of all important terms. It is designed to be equally valuable as a training aid and as a 'hot- line' reference when problems require urgent resolution.
Design and testing of an assessment instrument to measure understanding of protein structure and enzyme inhibition in a new context

Assessment instruments designed to measure student conceptual understanding and skills proficiency related to biochemistry are important to transform undergraduate biochemistry education. The purpose of this study was to develop an assessment instrument to measure student understanding of protein structure and enzyme inhibition in a new context, that of saturable binding. A community of biochemistry educators was involved in an iterative process of designing and testing of this assessment, which consists of true/false and open‐ended questions that map to low and high levels in Bloom's taxonomy. A total of 188 students' responses were collected from seven different institutions and were graded by two independent raters using a rubric. Results from this administration indicate that most students were able to answer the questions related to lower‐levels in Bloom's taxonomy; however for higher‐level questions, students had more difficulty. The results from this assessment can give instructors insight into the ways in which persistent incorrect or incomplete ideas related to protein structure and binding events can hinder knowledge application. Also, the use of a community of practice to develop assessment instruments of this type and the format of the instrument itself could be a useful model for development of assessment instruments in the future. © 2015 by The International Union of Biochemistry and Molecular Biology, 44:179–190, 2016.
Seed Dispersal and Ingestion of Insect‐Infested Seeds by Black Howler Monkeys in Flooded Forests of the Parana River, Argentina

All howler monkey species (Alouatta spp.) have a folivorous–frugivorous diet. Howler monkeys are reported to be seed dispersers in several areas, including black howlers (Alouatta caraya), which are important seed dispersers in northern Argentinean forests. The goal of this work was to study the three‐way interaction between insects, seeds, and black howlers, and assess the functional significance of this tri‐trophic interaction for seed dispersal. I determined through direct observation that fruits of species with a high proportion of insect infestation were important components of howler monkey diet. Ocotea diospyrifolia seeds from fresh faeces of black howlers contained dead larvae, but seeds were still able to germinate. Seeds in which larvae had reached an advanced stage of development did not germinate. Larvae of infested Eugenia punicifolia fruits were killed by digestion when they occurred in the pulp early in the fruiting season, but were dispersed alive with seeds later in the season. Banara arguta fruits contained both healthy and infested seeds; infested seeds were destroyed during digestion, while healthy seeds were dispersed. Black howlers' ingestion of infested fruits could result in the: (1) killing of larvae and dispersion of healthy seeds; (2) spread of larvae; or (3) destruction of infested seeds. This will depend on the relationship between the time at which fruit is consumed by black howlers, the time at which insect infestation occurs, and also probably on the hardness of the seed coat and the seed–insect size ratio.
Optimal dynamic pricing and replenishment policy for perishable items with inventory-level-dependent demand

An inventory system for perishable items with limited replenishment capacity is introduced in this paper. The demand rate depends on the stock quantity displayed in the store as well as the sales price. With the goal to realise profit maximisation, an optimisation problem is addressed to seek for the optimal joint dynamic pricing and replenishment policy which is obtained by solving the optimisation problem with Pontryagin’s maximum principle. A joint mixed policy, in which the sales price is a static decision variable and the replenishment rate remains to be a dynamic decision variable, is presented to compare with the joint dynamic policy. Numerical results demonstrate the advantages of the joint dynamic one, and further show the effects of different system parameters on the optimal joint dynamic policy and the maximal total profit.