Miracle-dz/UniFAR-FTUs huggingface dataset:
Surgical treatment outcomes of proximal humerus fractures including shoulder hemiarthroplasty in patients of the Orthopedics and Trauma Department in Siedlce

Proximal humerus fractures constitute 4-5% of all fractures occurring in adults. The aim of the study was to evaluate treatment outcomes for displaced proximal humerus fractures in patients eligible for surgical treatment who were hospitalized in the Orthopedics and Trauma Department of the Ministry of the Interior Hospital in Siedlce between 2016 and 2018. During this period, 153 patients with proximal humerus fractures were treated: 54 men (average age was 54 years) and 99 women (average age was 72 years). Surgical treatment was used in 112 patients. Follow-ups were carried out for 105 operated shoulders: 81 patients treated with intramedullary nailing group IIa, 13 patients treated with fixed-angle plate fixation – group IIb, 10 patients treated with hemiarthroplasty group III and 14 patients treated conservatively group I. The authors evaluated the results based on the functional assessment of the shoulder according to the modified Constant-Murley Score and the occurrence of complications in individual groups. The best outcomes were in the group of patients treated with intramedullary nailing (group IIa) – 49.4% good and very good outcomes, mean CM score of 67 was achieved. In group IIb, the average functional score was 56 points, in group III – 49 points. The worst functional outcomes were recorded in the non-surgical patients (group I), mean CM score of 39 points. As a result of complications, reoperation was necessary in 7 patients treated with internal fixation. Patients treated with hemiarthroplasty did not require revision surgery. The authors state that surgical treatment of displaced proximal humerus fractures gives better outcomes in the early followup period than the conservative treatment; in elderly patients who sustained comminuted fractures of the proximal humerus for which stable internal fixation cannot be performed, shoulder arthroplasty is recommended. According to the authors, none of the surgical methods of treating displaced proximal humerus fractures guarantees regaining full shoulder function.
Wounds and mental health care: system thinking

Purpose This paper considers how the quality of wound care delivered to people experiencing mental ill health can be improved at the system level in line with the global focus on improving population health. The purpose of this paper is to identify how the quality of wound care delivered to mental health care service users can be improved at a population level through system thinking informed by boundary theory. Design/methodology/approach This paper is a critical analysis of practice underpinned by systems thinking and boundary theory. Findings Tissue viability care and mental health care have different professional cultures and identities that are manifest in the way that they are organised and deliver care. If improvements in wound care-related outcomes at a population level are to be achieved, then it is important that the wound care needs of people experiencing mental ill health are addressed. Systems thinking and boundary theory provide a useful conceptual framework for informing quality improvement for people experiencing mental ill health at a population level. Integrated care plans are a useful mechanism for delivering comprehensive care that brings about wound healing and recovery from mental ill health. Social implications Integrated wound and mental health care plans transcend the professional boundaries that exist between tissue viability and mental health care services. Improvements in the quality and safety of care delivered to people with wounds who also utilise mental health services can be achieved through the use of integrated care plans. Health care policy and organisation need to meet the wound-related needs of people using mental health services. Originality/value There has been a focus on improving many aspects of wound care in line with the global focus on grand convergence in population health, but there has been very little emphasis on improving the wound-related outcomes of people that use mental health services. Systems thinking and boundary theory provide a useful framework for understanding how wound care for people experiencing mental ill health can be improved at a population level. Integrated care plans are a useful way of ensuring that safe high-quality wound care is consistently delivered to people experiencing mental ill health.
Effects of Cigarette Smoking on Retinal and Choroidal Thickness: A Systematic Review and Meta-Analysis

Background Cigarette smoking has been regarded as a risk factor for the incidence of a wide variety of chronic illness; however, its effect on thickness of the retina or choroid is still unknown. Methods A consummate literature search was conducted in PubMed and Embase up to January, 2018. The quantitative synthesis was conducted by Stata 12.0. Results A total of 13 observational studies were included in this meta-analysis. In this meta-analysis of all available observational studies, no significant effect of tobacco smoking on retinal or choroidal thickness change was detected. However, advanced analyses showed that smoking would influence the thickness of RNFL (average: SMD, −0.332; 95% CI, −0.637 to −0.027; inferior: SMD, −0.632; 95% CI, −1.092 to −0.172; and superior: SMD, −0.720; 95% CI, −0.977 to −0.463) and GCL (superior: SMD, −0.549; 95% CI, −0.884 to −0.215; inferior: SMD, −0.602; 95% CI, −0.938 to −0.265). Meanwhile, subgroup analyses demonstrated that the results based on studies in some regions (America and Africa) and cross-sectional studies showed a reduced choroidal thickness in smokers. No publication bias was detected in this study. Conclusion In conclusion, no significant effect of tobacco smoking on retinal or choroidal thickness change was detected. However, smoking would influence the thickness of RNFL and GCL. Future research on this field would help in the prevention and treatment of smoking-associated disorders.
Embolization of Bio-Alcamid Gluteal Injections in a Female Patient with Patent Foramen Ovale Leading to ARDS and Embolic Stroke

Bio-Alcamid is a non-FDA approved permanent dermal filler with a few known adverse effects including granuloma formation at injection site, skin infections, abscess and painful inflammation. Embolization of Bio-Alcamid has not been reported and likely represents a very rare complication. We present the case of a thirty-one-year-old female who presents with cough, dyspnea, hemoptysis, fever, and pleuritic chest pain several hours after receiving Bio-Alcamid gluteal injections. The patient’s symptoms progress rapidly and, within three days, she develops acute respiratory failure requiring intubation. A chest x-ray consistent with acute respiratory distress syndrome (ARDS) is viewed. Concurrently, a 2D echocardiogram reveals a patent foramen ovale (PFO) and severe pulmonary hypertension. Five weeks after initial presentation to the emergency department, the patient demonstrates flaccid quadriplegia, is poorly responsive when sedation is held, and her CT scan of the brain showed multifocal infarcts involving bilateral cerebral hemispheres. A CT of the abdomen reveals renal and splenic infarcts. This case study presents a rare complication of a nonbiodegradable dermal filler, Bio-Alcamid.
Characterization of novel LAP1 complexes and their relevance in DYT1 dystonia

Dystonia is the third most common movement disorder, following essential tremor and Parkinson’s disease, and comprises a large number of clinical syndromes. DYT1 dystonia is recognized as the most common form of early onset isolated dystonia and is caused by a mutation in the DYT1 gene, resulting in the loss of a single glutamic acid within the torsinA protein (ΔEtorsinA). TorsinA resides in the endoplasmic reticulum and nuclear envelope (NE), but the mutant form is abnormally relocated to the NE. At the NE, torsinA interacts with lamina associated polypeptide 1 (LAP1), whose function is poorly understood. LAP1 is a transmembrane protein of the inner nuclear membrane that was described to exist as three alternatively spliced isoforms (LAP1A, B and C) in rat. Protein-protein interactions are becoming increasingly important in the study of human diseases and signaling pathways. In this work, human LAP1B was identified as a novel protein phosphatase 1 (PP1) binding protein. PP1 is a major Ser/Thr phosphatase that is estimated to dephosphorylate about one third of all proteins in eukaryotic cells. The versatility of PP1 is only possible by complexing with different binding proteins that play regulatory and targeting roles. We found that LAP1B is a substrate of PP1 and binds to the latter through an RVxF-like motif located in the nucleoplasmic domain. In the course of this work, we also identified a novel human LAP1 isoform LAP1C that is Nterminally truncated. Human LAP1B and LAP1C isoforms seem to be developmentally regulated and are both dephosphorylated by PP1. Moreover, LAP1 proteins seem to be important for NE integrity and mitosis regulation. Given that PP1 interacts with LAP1 in the nucleoplasm, which in turn interacts with torsinA in the perinuclear space, the existence of the tricomplex PP1/LAP1/torsinA was validated in rat brain and cultured cells. Moreover, torsinA was dephosphorylated by PP1 but probably binds to the latter via LAP1. The aberrant behavior of ΔE-torsinA in the NE implicates nuclear dysfunction in DYT1 dystonia pathogenesis. Thereby, the role of LAP1 complexes in the NE and its regulation by protein phosphorylation may underlie the pathology of DYT1 dystonia and other NE-related diseases. Moreover, DYT1 dystonia has been related with a dysfunction in the basal ganglia circuit, including dopamine signaling disturbance. Interestingly, PP1/DARPP-32 cascade plays a key role in mediating the actions of dopamine and modulating the phosphorylation and activity of effectors in dopaminoceptors neurons. Thus, our results may lead to novel insights into the molecular and cellular mechanisms of DYT1 dystonia, where protein phosphorylation cascades represent a regulatory mechanism.
Detection of Offensive Tweets: A Comparative Study

With the growing popularity, Twitter has become a major platform for posting views via tweets. Tweets contain useful, relevant and offensive content as well. More than a decade of research has resulted in numerous techniques and models to detect offensive content. However, little is known about lexically offensive and contextual offensive content. In this research paper, lexical offensive contents have been identified using two techniques- Rule-Based Naive Bayes (RNB) and a collaborative model of LDA with Naive Bayes (LDANB). LDANB provides better results as compared to RNB for lexical offensive tweet detection. Further, contextually offensive contents are detected using newly devised Adjective Based approach. Contextual offensive content results prove to be better with Adjective based approach than Cosine similarity based results. To validate results of applied offensive tweet detection techniques three performance metrics- precision, Accuracy and recall are used.
Effect of Topical Anesthesia on Intraocular Pressure Measured by iCare Rebound Tonometer

Recently, iCare rebound tonometer (RT) has been introduced. It is portable and it does not require anesthesia and an experienced examiner. Several investigators have Z  ! Z=   coma. %   that RT tends to slightly overestimate intraocular pressure !  Z=    ' Some investigators reported that use of topical anesthetics can reduce the IOP measured by noncontact tonometry in adults. %    IOP readings measured by RT. This study did not found any significant change of IOP after topical anesthesia in children.    @ in healthy adult subjects.
Resilient architecture for network and control co‐design under wireless channel uncertainty in cyber‐physical systems

In this paper, we propose a resilient architecture for network and control co‐design, Wireless‐Simplex (W‐Simplex), which can ensure control performance by adaptively tuning the network and control parameters against wireless channel uncertainty in cyber‐physical systems. To the best of our knowledge, there has been no research into resilient network and control co‐design in response to the unreliable wireless channel. Our key observation is that rate adaptation may cause significant degradation in control performance or even system instability. This performance degradation is contrary to the intuition that rate adaptation provides a reliable link under wireless channel uncertainty. We explain the cause of this phenomenon and resolve the situation by proposing a resilient co‐design algorithm in an optimization framework. Our simulation study with ns‐2 shows the effectiveness of the proposed scheme to provide resilience of cyber‐physical systems against wireless channel uncertainty.
Protection against periodontal destruction in diabetic condition with Sardinella longiceps fish oil: expression of matrix-metalloproteinase 8 and tissue inhibitor of metalloproteinase 1

Background: There is strong evidence to support the claim that periodontitis may be more prevalent among diabetic individuals. Collagen degradation represents one of the key events in periodontal destructive lesions. The level of matrix metalloproteinase 8 (MMP-8) and tissue inhibitor of metalloproteinase 1 (TIMP-1) are key to periodontal collagenolysis and associated with the severity of periodontal inflammation and disease. Host modulatory therapy has been proposed as a treatment for periodontal diseases. Sardinella longiceps (lemuru) fish oil containing polyunsaturated fatty acids (PUFAs), including omega 3 and 6, has been shown to possess therapeutic anti-inflammatory and protective properties effective against inflammatory diseases, including periodontitis. Purpose: The study aimed to examine the effect of dietary supplementation of Sardinella longiceps fish oil on protection against periodontal destruction resulting from the expression of MMP-8 and TIMP-1. Methods: Wistar rat samples are divided into four groups: a negative control group and three groups receiving Sardinella longiceps fish oil treatment (4 ml/ weight (Kg), 8 ml/ weight (Kg) and 16 ml/ weight (Kg). One week before treatment, all groups were administered with streptozotocin (STZ) 65 ml/ weight (Kg) and nicotinamide 110 ml/ weight (Kg) to induce diabetic conditions. Immunohistochemistry slides of periodontal tissues were prepared after three weeks of treatment. The expression of MMP-8 and TIMP-1 was counted using the HSCORE index, data was analyzed by means of non-parametric methods using Kruskal-Wallis, and Mann-Whitney tests. Results: Statistical analyses confirmed a significant increase in MMP-8 expression and a reduction in TIMP-1 expression in the negative control group compared to the treatment group (p<0.05). Meanwhile, the treatment group showed a significant reduction in MMP-8 expression and a marked increase in TIMP-1 expression, with the best result produced by the administering of 16 ml/ weight (Kg) Sardinella longiceps fish oil to the treatment group (p<0.05). Conclusion: Dietary supplementation of Sardinella longiceps fish oil can protect against periodontal destruction under diabetic conditions, by decreasing MMP-8 expression and increasing TIMP-1 expression.
Short-term Electrical Load Prediction Using Evolving Neural Network

A short-term electrical load prediction can use an artificial neural network approach. In this paper, an optimized neural network, namely Evolving Neural Network (ENN) has been developed for short term electric load prediction. ENN uses a genetic algorithm to optimize the weighting of neural networks. After the feedforward algorithm, the process continues with optimization, instead of learning process normally applied to the neural network. The proposed algorithm is implemented in MatLab. Data from April 2010 to April 2011 will be used as training data and data in May 2011 will be used as checking data. To evaluate the performance of Evolving Neural Network, Wavelet Neural Network (WNN) is also involved for comparison. The evaluation is conducted by observing the prediction results. Performance measurements are performed by observing errors that occur. The smaller the error value, the better the accuracy. The experimental result shows that the accuracy performance of ENN is better than WNN.
ÆTIOLOGICAL ASPECTS OF THE SCHIZOPHRENIA–LIKE PSYCHOSIS OF TEMPORAL–LOBE EPILEPSY

The significant negative correlation of the antibiotic serum level on uniform distribution and body fat suggested that body fat might have played some part in the distribution of erythromycin, but the compartson of the levels in seven males and seven females with equal amounts of bodY fat but different amounts of body water indicated that the distribution of the antibiotic was quantitatively almost entirely determined by total body water. A wide range of serum levels among subjects was found after oral administration of the erythromycin, and, in view of the dynamics of the absorption, distribution and excretion of the drug, it would not be expected that either the peak or the four-hour average levels would correlate with body water, body fat or body weight. However, with regard to the absorption at peak and four-hour average, the results indicated that the amount of erythromycin absorbed was greater in heavier subjects. It is interesting to note, in this respect, that drug dosage for children is, in general, proportionately higher on a body weight basis than for adults (Leach and Wood, 1967). The observation that the amount of erythromycin absorbed was greater in those people with greater body weight requires further elucidation. Erythromycin estolate has a high lipid solubility and a pKa near to neutrality (6·9). Presumably, therefore, it would be a suitable marker substance to indicate the extent and efficiency of the gut absorbing surface. Among the many complexities of absorption, presumably one of the major factors would be the distribution of the drug within the upper part of the small intestine and the surface area available for absorption. ThUS, it may be that larger people have a greater gut absorbing surface area, or else may be more efficient in absorption. There does not appear to be any literature pertinent to the question of gut absorbing surface in relation to various body compartments, singly or combined. The questions raised by the study appear to have far-reaching implications and will require further extensive investigation. SUMMARY
A Semantic Approach to Evaluate Web Content of Government Websites

Government agencies rely on websites to disseminate large volumes of information to the citizens. As public information changes over time due to changes in laws and regulations, maintaining currency and consistency of the web content becomes acutely important. Government agencies have to regularly evaluate the web content (WC) to ensure high quality of information available to the citizens, businesses, and public administrators. Currently there exists no standardized approach for monitoring and maintaining WC. In this chapter, the authors propose a WC ontology for the systematic and formal representation of the concepts and functions associated with the evaluation of web content on government websites. An ontology-based evaluation tool is proposed that can be used to improve the quality of web content and efficiency of the evaluation process. The ontological approach holds promising features and benefits including information sharing, reducing time and paperwork during evaluation, assuring more accurate results, and communicating evaluation results to knowledge engineers, public administrators, evaluators, and decision makers engaged in e-government initiatives.
A survey on network intrusion detection system techniques

Security is the emerging trend in today’s modern world. Whole world is connected with some network capabilities and transmission of data becomes easier and faster. Nowadays, several places were implemented with network like schools, banks; offices etc. and many individuals are adopted with social network media. Several techniques were developed for improving the security aspects for network related issues. But still, vulnerable attacks are taken place and dominate the security aspects to pertain their strength towards various kinds of attack possibilities. For this reason, several network intrusion detection systems (NIDS) were proposed to protect computers as well as networks. It safeguards data integrity, system availability, and confidentiality from several kinds of attacks. In this paper, we study about the various types of network attacks and intrusion detection system to prevent from these attacks. Also, challenges that are faced by NIDS are discussed and comparison of different techniques and analysis are given in detail. The performance accuracy of each classifier that is previously proposed is comprised.
Associations between breastfeeding duration and overweight/obese among children aged 5–10: a focus on racial/ethnic disparities in California

Research on the association between breastfeeding and childhood obesity and research on racial/ethnic differences in breastfeeding both show inconsistencies. The current study examines: 1) whether immigrant Hispanic women have higher rates of breastfeeding compared to non-Hispanic (three separate groups: African-American, Asian/Pacific Islander, and White) and U.S.-born Hispanic women; 2) whether children who were breastfed are less likely to be overweight/obese compared to children who were not breastfed; and 3) whether associations between breastfeeding and weight status vary by race/ethnicity/nativity. The study builds on prior literature using representative data from the Geographic Research On Wellbeing study (GROW, 2012–2013) and focusing on ages 5–10 years, an age group that has not been well studied (N = 2675 mother/child dyads). Logistic regression was used to investigate the odds of child obesity (≥95th%) and child overweight (≥85th%) in a series of models: unadjusted (each variable individually), demographic (child's sex, child's age, mother's age, mother's race/ethnicity, and mother's marital status), socioeconomic status (mother's education and family income), and full model (mother's BMI); with breastfeeding included in all models. Interactions between race/ethnicity and breastfeeding duration were also examined. African-American (9.54%) and white (32.8%) women had the lowest and highest rates of ever breastfeeding, respectively. White women breastfed the longest (M = 10.52 months, SE = 0.028) and U.S.-born Hispanic women breastfed the shortest (M = 7.05 months, SE = 0.41), on average. Children of African-American and U.S.-born Hispanic mothers had higher odds of being overweight/obese (74–75%) compared with children of white mothers. No associations were found between breastfeeding duration and child's weight status in adjusted models, nor was there a significant interaction between mother's race/ethnicity and breastfeeding duration on child's weight status; however, mother's own weight status was a significant driver of child's weight status and explained the racial/ethnic disparities. These results provide evidence in favor of there being no association between breastfeeding and childhood obesity.