Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Human Leukocyte Antigen Compatibility on Kidney Graft Survival: Comparative Analysis of Two Decades

Background. Based on an analysis of United Network for Organ Sharing data, it was reported that the influence of human leukocyte antigen (HLA) matching in renal transplantation has diminished in recent years, prompting the suggestion that donor kidney allocation algorithms should be revised. Methods. We compared the impact of HLA matching on kidney graft survival during the decades 1985–1994 and 1995–2004 using the data of the Collaborative Transplant Study. Results for the last 5 years (2000–2004) were analyzed separately in addition. Multivariate Cox regression analysis was used to account for the influence of confounders. Results. Our results show that, while graft survival rates have improved overall over time, the relative impact of HLA matching on the graft survival rate has remained strong and highly significant. Both the need for posttransplant rejection treatment and the graft survival rates showed statistically highly significant associations with HLA matching regardless of the interval analyzed (P<0.001). Conclusions. We conclude that HLA mismatches significantly influence the outcome of kidney transplants and that kidney exchange programs for the purpose of achieving better HLA matches continue to be meaningful.
Reproductive Toxicology of Tartrazine (FD and C Yellow No. 5) in Swiss Albino Mice

Problem statement: Tartrazine (FD and C Yellow No. 5) is an orange-colored widely used in food products, drugs and cosmetics. This color has a potential toxicological risk. The current study evaluated the effect of sub-chronic consumption of tartrazine on the male reproductive system. Approach: Tartrazine was administered to adult male mice in drinking water at doses of 0, 0.1, 1 and 2.5% for 13 weeks. After that period, the weights of testes, epididymides and seminal vesicles were determined. Sperm counts in the testis and epididymides, motility, morphology and testis histology were assessed. Results: Body weight gain, absolute and relative testis, epididymis and seminal vesicles weights did not change. However, sperm count was decreased and sperm abnormalities were increased in the 2.5% tartrazine treated groups compared to the control. Sperm motility and histological changes in testis were observed in the middle and high treated groups. Conclusion/Recommendations: We concluded that excessive tartrazine consumption can have adverse effects on the male reproductive function. We suggested conducting surveys among the population to estimate their daily intake.
The Far Lateral Transpontomedullary Sulcus Approach to Pontine Cavernous Malformations: Technical Report and Surgical Results

BACKGROUND: Pontine cavernous malformations (CMs) located on a peripheral pontine surface or the fourth ventricular floor are resectable lesions, but those deep within the pons away from a pial surface are typically observed. However, the anterior bulge of the pons formed by the brachium pontis creates a unique entry point for access to deep pontine lesions from below, working upward through the pontomedullary sulcus. OBJECTIVE: We developed a transpontomedullary sulcus (TPMS) approach to these lesions. METHODS: The TPMS approach used the far lateral craniotomy and upper vagoaccessory triangle to define the surgical corridor. The entry point was above the olive, lateral to the pyramidal tracts and cranial nerve (CN) VI, above the preolivary sulcus and CN XII, and medial to CNs VII and VIII and CNs IX through XI. RESULTS: Four patients underwent this approach. All presented with hemorrhage and CN VI palsies. All pontine CMs were resected completely. Three patients were improved or unchanged, with good outcomes (modified Rankin Scale score ⩽2) in all patients. CONCLUSION: The central pons remains difficult territory to access, and new surgical corridors are needed. The bulging underbelly of the pons allows access to pontine lesions deep to the pial surface from below. The far lateral TPMS approach is a novel and more direct alternative to the retrosigmoid transmiddle cerebellar peduncle approach. Unlike the retrosigmoid approach, the TPMS approach requires minimal parenchymal transgression and uses a brainstem entry point medial to most lower CNs. Favorable results demonstrate the feasibility of resecting pontine CMs that might have been previously deemed unresectable. ABBREVIATIONS: AICA, anterior inferior cerebellar artery CM, cavernous malformation CN, cranial nerve MCP, middle cerebellar peduncle mRS, modified Rankin Scale PICA, posterior inferior cerebellar artery PMS, pontomedullary sulcus TPMS, transpontomedullary sulcus
Crossing the Secular Divide: Government and Faith-Based Organizations as Partners in Health

Recent debate over the relationship between government and faith-based organizations has renewed interest in the opportunities and challenges that are associated with change in this area of health care policy. Experience exists already that faith-based organizations can provide effective health education and services in the community. Limited infrastructure and liability are among the important barriers to their expansion. Spurred by the demographics of an aging population and increasing health care costs, we argue the necessity of further partnering, within well-defined limits, to maximize the availability of health care education and services throughout this nation.
Effect of Warm‐Up and Flexibility Treatments on Vertical Jump Performance

Although different warm-up and flexibility routines are often prescribed before physical activity, little research has been conducted to determine what effects these routines have on athletic performance in activities. The purpose of this investigation was to determine to what degree different warm-up routines affect performance in the vertical jump test. The 40 female participants were asked to perform a general warm-up only, a general warm-up and static stretching, and a general warm-up and proprioceptive neuromuscular facilitation (PNF) on 3 nonconsecutive days. Each of the treatments was followed by a vertical jump test. A 1-way repeated-measures analysis of variance revealed a significant difference in vertical jump performance. A post hoc analysis revealed decreased vertical jump performances for the PNF treatment group. Based on the results of this study, performing PNF before a vertical jump test would be detrimental to performance.
An Ontology and Data Infrastructure for Publishing and Using Biographical Linked Data

This paper describes the ontology model and published datasets of a digitized biographical person register. The applied ontology model is designed to represent people via their enduring roles and perduring lifetime events. The model is designed to support 1) prosopographical Digital Humanities research, 2) linking to resources in semantic Cultural Heritage portals, and 3) semantic data validation and enrichment by using SPARQL queries. The linked data approach enables to enrich a person’s biography by interlinking it with space and time related biographical events, persons relating by social contacts or family relations, historical events, and personal achievements.
Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2.

Activation of receptor tyrosine kinases by autophosphorylation is one of the most common and critical transformations in signal transduction, yet its role in catalysis remains controversial. Autophosphorylation of the angiogenic receptor tyrosine kinase Tie2 was studied in terms of the autophosphorylation sites, sequence of phosphorylation at these sites, kinetic effects, and mechanistic consequences. Isoelectric focusing electrophoresis and mass spectrometric analysis of a Tie2 autophosphorylation time course showed that Tyr992 on the putative activation loop was phosphorylated first followed by Tyr1108 in the C-terminal tail (previously unidentified autophosphorylation site). Autophosphorylation of Tie2 to produce pTie2 resulted in a 100-fold increase in k(cat) and a 460-fold increase in k(cat)/K(m). Viscosity studies showed that the unphosphorylated Tie2 was partially limited by product diffusion ((k(cat))(eta) = 0.67 +/- 0.06), while product release was more rate-limiting ((k(cat))(eta) = 0.94 +/- 0.08) for autophosphorylated Tie2 (pTie2). Furthermore, autophosphorylation did not significantly affect the phosphoacceptor dissociation constants. There was a significant (k(cat))(H)/(k(cat))(D) solvent isotope effect (SIE) for unphosphorylated Tie2 (2.42 +/- 0.12) and modest SIE (1.28 +/- 0.04) for pTie2, which is consistent with the chemistry step being more rate-limiting for Tie2 as compared to pTie2. The pH-rate profiles of Tie2 and pTie2 revealed a >0.5 unit shift in the pK(a) values of catalytically relevant ionizable residues upon autophosphorylation. The shift in rate-limiting step will result in a different distribution of enzyme pools (e.g., E, E*S, E*P, etc.) which may modulate the susceptibility to inhibition. Tie2 and pTie2 were profiled with a panel of known ATP-competitive kinase inhibitors. Tie2 activation perturbs catalytic residue ionizations, shifts the rate-limiting step to almost exclusive diffusion-control, and transforms the kinase into a more perfect catalyst.
Kinematic measurements of the vocal-fold displacement waveform in typical children and adult populations: quantification of high-speed endoscopic videos.

PURPOSE This article presents a quantitative method for assessing instantaneous and average lateral vocal-fold motion from high-speed digital imaging, with a focus on developmental changes in vocal-fold kinematics during childhood. METHOD Vocal-fold vibrations were analyzed for 28 children (aged 5-11 years) and 28 adults (aged 21-45 years) without voice disorders. The following kinematic features were analyzed from the vocal-fold displacement waveforms: relative velocity-based features (normalized average and peak opening and closing velocities), relative acceleration-based features (normalized peak opening and closing accelerations), speed quotient, and normalized peak displacement. RESULTS Children exhibited significantly larger normalized peak displacements, normalized average and peak opening velocities, normalized average and peak closing velocities, peak opening and closing accelerations, and speed quotient compared to adult women. Values of normalized average closing velocity and speed quotient were higher in children compared to adult men. CONCLUSIONS When compared to adult men, developing children typically have higher estimates of kinematic features related to normalized displacement and its derivatives. In most cases, the kinematic features of children are closer to those of adult men than adult women. Even though boys experience greater changes in glottal length and pitch as they mature, results indicate that girls experience greater changes in kinematic features compared to boys.
FPGA-Based Scalable and Power-Efficient Fluid Simulation using Floating-Point DSP Blocks

High-performance and low-power computation is required for large-scale fluid dynamics simulation. Due to the inefficient architecture and structure of CPUs and GPUs, they now have a difficulty in improving power efficiency for the target application. Although FPGAs become promising alternatives for power-efficient and high-performance computation due to their new architecture having floating-point (FP) DSP blocks, their relatively narrow memory bandwidth requires an appropriate way to fully exploit the advantage. This paper presents an architecture and design for scalable fluid simulation based on data-flow computing with a state-of-the-art FPGA. To exploit available hardware resources including FP DSPs, we introduce spatial and temporal parallelism to further scale the performance by adding more stream processing elements (SPEs) in an array. Performance modeling and prototype implementation allow us to explore the design space for both the existing Altera Arria10 and the upcoming Intel Stratix10 FPGAs. We demonstrate that Arria10 10AX115 FPGA achieves 519 GFlops at 9.67 GFlops/W only with a stream bandwidth of 9.0 GB/s, which is 97.9 percent of the peak performance of 18 implemented SPEs. We also estimate that Stratix10 FPGA can scale up to 6844 GFlops by combining spatial and temporal parallelism adequately.
Power electronic devices for renewable power systems

In the past, overhead lines, cables, transformers and circuit breakers represented the core components of electric power systems. However, in light of a considerable and still increasing share of renewable energy sources in grids, a change in electricity infrastructure can be observed. Over the last decades advances in power semiconductor devices have paved the way for innovative equipment such as HVDC transmission lines or FACTS devices. Thus, semiconductor-based power conversion represents a key enabling technology to meet the challenges of tomorrow's electricity supply. In this paper, power semiconductors will be investigated with regard to the utilization in renewable power systems. The specific advantages of these devices in different applications such as future dc distribution, wind and photovoltaic power conversion will be discussed. Different semiconductor materials, for instance silicon carbide will also be addressed.
Biphasic regulation of macrophage attachment by activators of cyclic adenosine monophosphate‐dependent kinase and protein kinase C

A method is described that enabled us to study the adhesiveness of J‐774 murine macrophages. Cell attachment was stimulated by activators of kinase C (i.e., phorbol esters) as well as kinase A (cyclic adenosine monophosphate; cAMP). This novel effect of cAMP was observed when its levels were increased via receptor triggering (prostaglandin E1, β‐adrenergic agonists), activation of Ns (cholera toxin), or inhibition of phosphodiesterase (Ro 20‐1724) or when the kinase was directly activated by Br8‐cAMP. The simultaneous treatment with kinase A and kinase C activators at the time of attachment resulted in a partially additive response. On the other hand, preincubation of the cells in suspension with one of the activators rendered them refractory to subsequent stimulation at the onset of the adhesion assay, whatever agent was used. Such a refractoriness was also observed in cells preincubated with oleoyl‐acetyl‐glycerol (OAG). On the other hand, when added at the time of attachment, this near‐physiological activator of kinase C evoked a biphasic response: the early stimulation of cell attachment was followed by an accelerated rate of “detachment. ” In conclusion, kinase C and kinase A play a role in the sequence of events leading to cell adhesion. The cross desensitization observed is distal and takes place at or beyond the kinase step.
Formation and mitigation of heterocyclic aromatic amines in fried pork

Heterocyclic aromatic amines (HAAs) are potent mutagens and carcinogens generated during the heat processing of meat. HAAs, which are abundant in processed meat products, include 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx), and 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP). The content of these three HAAs in fried pork was determined by LC-MS/MS. The effects of frying time and temperature, sample shape, and addition of antioxidants on the generation of HAAs were investigated. The results show that HAAs were produced during frying, and their levels increased with increasing frying time and temperature. Pork patties had the highest concentration of HAAs compared with pork meatballs and pork strips. The addition of antioxidant of bamboo leaves (AOB), liquorice extract, tea polyphenol, phytic acid and sodium iso-ascorbate to pork before frying had an inhibitory effect on HAA generation, with AOB being the most effective antioxidant. Inhibition levels of nearly 69.73% for MeIQx, 53.59% for 4,8-DiMeIQx and 77.07% for PhIP in fried pork were achieved when the concentrations of AOB added were 0.02, 0.01 and 0.10 g kg−1, respectively.
Intermediate‐conductance calcium‐activated potassium channels participate in neurovascular coupling

BACKGROUND AND PURPOSE Controlling vascular tone involves K+ efflux through endothelial cell small‐ and intermediate‐conductance calcium‐activated potassium channels (KCa2.3 and KCa3.1, respectively). We investigated the expression of these channels in astrocytes and the possibility that, by a similar mechanism, they might contribute to neurovascular coupling.
Growth Optimization, Strain Compensation and Structure Design of InAs/GaSb Type-II Superlattices for Mid-Infrared Imaging

InAs/GaSb type-II superlattce (T2SL) photodetector structures at the MWIR regime were grown by molecular beam epitaxy. The growth temperature and group-V soaking times were optimized with respect to interface and transport quality. Novel strain compensation schemes with insertion of InSb layers were proposed and tested to be efficient to tune the overall strain between tensile and compressive without degradation of interface and optical quality. The effect of the proposed methods is modeled by analytic functions. Band structure calculations were also carried out for the proposed T2SL structures to assist optimizing sample designs. Single pixel photodiodes with a low dark current were demonstrated.
PSO-based spatial scheduling algorithm for hull curved block construction

Spatial scheduling aims to create efficient spatial utilization and optimal temporal scheduling. In this paper a spatial scheduling approach based on an improved particle swarm optimization algorithm was proposed to determine the optimal processing sequence and spatial location of blocks. To minimize processing time and maximize spatial utilization, the adaptive inertia weight strategy was used to ensure the algorithm converged. Selection operator and mutation operator were used in the algorithm to improve the convergence rate and to prevent locally optimal solution. Heuristic positioning strategy was developed to determine the location of blocks. Finally, a simulation was examined to show the validity of the proposed algorithm.
An Organism resembling the Newcastle Type of Dysentery Bacillus associated with Cases of Dysentery

Six strains of an organism associated with and apparently etiologically related to clinical cases of dysentery have been described. Five of these strains were isolated from cases in a town in Lancashire and the other from a case in Nigeria. These strains seem to be identical with the Newcastle dysentery bacillus described by Clayton and Warren except for the apparently constant difference in the action on mannite. Their relationship to the Flexner group of dysentery bacilli has been discussed.
Don ’ t Caresin Logic Minimization of ExtendedFinite StateMachines

Extended Finite State Machines (EFSMs) have been proposedto model control oriented systems. A version of this, with the data portion modeledby Presburger arithmetic, has beenusedin formal verification and testpattern generation.This paper proposesa general logic minimization schemeusing don’t carederived fr om both control and data path. It consistsof methodsto transfer don’t caresthr ough the data path and to generate logic don’t cares fr om the data path using quantifier-fr eePresburger inequalities. Potential applications are discussedand preliminary resultsvalidate the schemeon reasonableexamples.
Development and experimental in vivo validation of mathematical modeling of laser coagulation

Most clinical procedures using the laser are based on thermal laser‐tissue interactions. The treatment often consists of inducing damage of given degree and extent by heating the tissue. The aim of this study was to develop a model called HELIOS. The ability of HELIOS to predict thermal coagulation was evaluated by comparison with in vivo experimental results. Conversion of laser light in tissue was studied using the beam‐broadening model. Temperature was described by the heat conduction equation solved using the finite difference method. The tissue dena‐turation was modeled by the Henriques equation leading to the determination of the damage coefficient ω. For a given set of laser and tissue parameters, HELIOS makes a graphic representation of coagulation necrosis and temperature evolution in tissue. HELIOS was validated by experimental studies in vivo on rat liver using a CW Nd:YAG laser, a CO2 laser, and an argon laser. For given sets of laser parameters, temperature measurements were performed using an infrared camera. Histological examinations were carried out on samples to quantify the depth of coagulation necrosis. Experimental data obtained in vivo were compared with those calculated using HELIOS and similar sets of parameters. The difference between the predicted temperature evolution on tissue surface and that measured by the infrared camera was < 5°C in all cases. The difference between the predicted coagulation necrosis depth and the corresponding experimental one was < 10%. In conclusion, HELIOS allows good prediction of tissue temperature and coagulation necrosis. © 1994 Wiley‐Liss, inc.
Cumulative exposure to nucleoside analogue reverse transcriptase inhibitors is associated with insulin resistance markers in the Multicenter AIDS Cohort Study

Objective:To estimate insulin resistance and its relationship to antiretroviral therapy (ART) in a cohort of HIV-infected persons with comparison to HIV-seronegative controls. Design:Prospective cohort of 533 HIV-infected and 755 HIV-seronegative men in the Multicenter AIDS Cohort Study evaluated at 6-month intervals between 1999 and 2003. Methods:Recent ART exposure was assessed by type of treatment in the preceding 6 months [i.e., no ART, monotherapy, combination ART, or highly active antiretroviral therapy (HAART) with and without a protease inhibitor (PI)]. Cumulative exposure was determined for the three major ART classes and for individual medications within each class. Two endpoints, a modified QUICKI index, 100 × 1/[log10(glucose) + log10(insulin)] and fasting hyperinsulinemia (insulin > 15 μU/ml), were assessed. All statistical models were adjusted for age, body mass index, race, nadir CD4 cell count, hepatitis C serostatus and family history of diabetes mellitus. Results:Each of the HIV-infected groups had higher odds of hyperinsulinemia and lower mean QUICKI than the HIV-seronegative men. Each additional year of exposure to nucleoside analogue reverse transcriptase inhibitors (NRTI) was associated with increased odds of hyperinsulinemia [odds ratio (OR), 1.08; 95% confidence interval (CI), 1.02–1.13) and a lower QUICKI (−0.04; 95% CI, −0.07 to −0.01). Cumulative exposure to non-nucleoside analogue reverse transcriptase inhibitors or PI drugs was not associated with either insulin resistance marker. Of individual medications examined, stavudine was associated with the highest risk of hyperinsulinemia (OR, 1.2; 95% CI, 1.2–1.3). Conclusions:Fasting surrogate markers suggest increased insulin resistance in HIV-infected men, which is related to cumulative NRTI exposure.