Miracle-dz/UniFAR-FTUs huggingface dataset:
Inseguridad, precariedad e inestabilidad: retrato de la inserción laboral femenina || Insecurity, precariousness and instability: portrait of female employment

Una de las principales consecuencias de la crisis mundial ha sido el aumento de las tasas de desempleo y la proliferacion en la mayoria de los paises del empleo precario, entendiendo este como incierto, imprevisible y que puede desentranar un riesgo para el trabajador. Esta situacion ha desencadenado una percepcion negativa del mercado laboral ya que esta asociada, en parte, a los episodios de empleo que las personas hayan tenido en su historia mas reciente. La presente investigacion pretende analizar la percepcion del mercado laboral de una muestra 144 mujeres (98 que han accedio al mercado en el ultimo ano y 46 paradas de larga duracion) a traves de un analisis de contenido de entrevistas telefonicas semiestructuradas. Los resultados determinan que el acceso al empleo viene caracterizado por miedo a su perdida, mayor precariedad laboral, aumento de los contratos temporales y de jornada a tiempo parcial, caracteristicas aludidas en investigaciones precedentes, ya que reflejan el cambio de modelo economico resultante en parte, por la condicion de flexibilidad en el mercado de trabajo.
Structural changes in the retinal microvasculature and renal function.

PURPOSE To evaluate the associations between chronic kidney disease (CKD) and microalbuminuria, and a comprehensive range of retinal microvascular abnormalities including traditional and new retinal vascular measures. METHODS This was a population-based, cross-sectional study on 3280 urban Malay adults. The albumin/creatinine ratio (ACR) was calculated from spot urine samples. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine concentration. Retinal vascular caliber and geometry were quantified from retinal fundus photographs using a semiautomated computer-assisted program. Qualitative changes including focal arteriolar narrowing, arteriovenous nicking, and opacification of the arteriolar wall were assessed by trained graders. RESULTS In multivariate analyses adjusting for age, sex, hypertension, diabetes, and smoking, narrower retinal arteriolar caliber (P = 0.008), smaller retinal vascular fractal dimensions (P = 0.014), and the presence of AV nicking and opacification (P = 0.005 and P < 0.001, respectively) were significantly associated with lower eGFR. In multivariate adjusted logistic regression analyses, none of the retinal markers was associated with CKD. A smaller fractal dimension (P < 0.001) and the presence of focal arteriolar narrowing, AV nicking and opacification were associated with higher ACR (P < 0.001, P = 0.01, and P = 0.002, respectively). Narrower retinal arterioles (P = 0.041); smaller fractal dimensions (P = 0.006); and focal arteriolar narrowing, AV nicking, and opacification (P = 0.007, P = 0.007, and P = 0.012, respectively) were associated with higher likelihoods of having microalbuminuria. CONCLUSIONS Quantitative changes of the retinal vascular geometry and qualitative changes in the vessel architecture are associated with markers of renal dysfunction and damage.
TopBP1 makes the final call for repair on the verge of cell division

ABSTRACT Mitosis is the process responsible for segregation of the duplicated genome into 2 new daughter cells. We recently identified an important function of the protein TopBP1 during mitosis by showing that TopBP1 suppresses transmission of DNA damage to daughter cells. Here, we further discuss the implications of our findings.
Knowledge search modes and innovation performance: The moderating role of strategic R&D orientation

ABSTRACT Prior studies implicitly assume that knowledge search modes are homogeneous, and little is known about the impacts of specific search modes on innovation. Drawing upon the knowledge search literature, we differentiate among four types of search modes and analyze their impacts on innovation performance. Moreover, we enrich the theoretical framework by recognising the moderating role of strategic R&D orientation in affecting the relationship between specific types of search modes and innovation performance. Using a unique dataset of 418 Chinese firms, we find that, except for inward licensing, value chain search, capital search, and industry-university-research institute collaboration (IUR collaboration) exert positive effects on innovation performance. Moreover, the empirical results indicate that a strategic R&D orientation amplifies the positive effects of value chain search and IUR collaboration while it mitigates the negative effect of inward licensing on innovation performance.
What causes deforestation in Indonesia?

We investigate the causes of deforestation in Indonesia, a country with one of the highest rates of primary natural forest loss in the tropics, annually between 2001 and 2016. We use high spatial resolution imagery made available on Google Earth to characterize the land cover types following a random selection of deforestation events, drawn from the Global Forest Change dataset. Notorious in the region, large-scale oil palm and timber plantations together contributed more than two-fifths of nationwide deforestation over our study period, with a peak in late aughts followed by a notable decline up to 2016. Conversion of forests to grasslands, which comprised an average of one-fifth of national deforestation, rose sharply in dominance in years following periods of considerable fire activity, particularly in 2016. Small-scale agriculture and small-scale plantations also contributed one-fifth of nationwide forest loss and were the dominant drivers of loss outside the major islands of Indonesia. Although relatively small contributors to total deforestation, logging roads were responsible for a declining share of deforestation, and mining activities were responsible for an increasing share, over the study period. Direct drivers of deforestation in Indonesia are thus spatially and temporally dynamic, suggesting the need for forest conservation policy responses tailored at the subnational level, and new methods for monitoring the causes of deforestation over time.
Regime Changes in the Relationship between Stock Market Return and the Growth Rates of Output and Money Supply in Thailand

This paper examines the relationship between stock market return and two main macroeconomic variables (output growth and money growth) in Thailand during 1997Q3 and 2017Q4. The results from Markov switching vector autoregressive model reveal that there is regime switching between the bull market and the bear market. The positive impact of output growth on stock market return is significant in the bear market while the impact of money growth on stock market return is positive and significant in the bull market. This implies that monetary policy is effective only during the bull market period. For the bear market period, measures that stimulate economic growth should be necessary.
Understanding polysaccharide production and properties using seed coat mutants: future perspectives for the exploitation of natural variants.

BACKGROUND The epidermal cells of the seed coat of certain species accumulate polysaccharides during seed development for cell wall reinforcement or release on imbibition to form mucilage. Seed-coat epidermal cells show natural variation in their structure and mucilage production, which could explain the diverse ecophysiological roles proposed for the latter. Arabidopsis mucilage mutants have proved to be an important tool for the identification of genes involved in the production of seed-coat polysaccharides. SCOPE This review documents genes that have been characterized as playing a role in the differentiation of the epidermal cells of the arabidopsis seed coat, the natural variability in polysaccharide features of these cells and the physiological roles attributed to seed mucilage. CONCLUSIONS Seed-coat epidermal cells are an excellent model for the study of polysaccharide metabolism and properties. Intra- and interspecies natural variation in the differentiation of these epidermal cells is an under-exploited resource for such studies and promises to play an important part in improving our knowledge of polysaccharide production and ecophysiological function.
Sex Differences in Youth-Reported Depressive Symptomatology and Unwanted Internet Sexual Solicitation

Background As the number of youths using the Internet regularly increase, so too does the number of youths potentially vulnerable to negative experiences online. Clinicians, policy makers, and parents need to better understand the Internet and factors related to positive and negative experiences online. Objective Primarily to investigate the association between youth-reported depressive symptomatology and unwanted Internet sexual solicitation and secondarily to identify sex differences in related characteristics of affected youth. Methods Data from the Youth Internet Safety Survey were analyzed to investigate the association between reported depressive symptomatology and unwanted Internet sexual solicitation. The Youth Internet Safety Survey was a nationally-representative, cross-sectional telephone survey. Youth participants (N = 1501) were English speakers between the ages of 10 and 17 years who had accessed the Internet at least 6 times in the previous 6 months and had resided in the household for at least 2 weeks in the previous year. Eighty-two percent of contacted households agreed to participate. Each participant was asked to indicate whether any of the 9 symptoms of major depression defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) had been present within the previous month. Logistic regression was used to estimate the odds of reporting an unwanted sexual solicitation online for youths with mild or major depressive symptomatology versus no symptomatology. A parsimonious, multivariate model of significant youth characteristics was identified separately for males and females. Results Youths who report major depressive-like symptoms were 3.5 times more likely (odds ratio, 3.54; 95% confidence interval, 2.19-5.71) to also report an unwanted sexual solicitation online compared to youths with mild/no symptomatology. After adjusting for significant Internet and psychosocial characteristics, male Internet users who report major depressive-like symptomatology were 2.5 times more likely to also indicate an unwanted Internet solicitation (adjusted odds ratio, 2.72; 95% CI, 1.15-6.40); significant differences were not observed among otherwise-similar females. Further, among youths reporting an Internet solicitation (N = 283), youths with major depressive-like symptomatology were twice as likely to report feeling emotionally distressed by the incident compared to youths with mild/no symptomatology (odds ratio, 2.27; 95% CI, 1.03-5.02). Conclusions While the majority of youths report positive experiences online, some youths may be more vulnerable to negative experiences. Cross-sectional results indicate that the report of depressive symptomatology is significantly related to the concurrent report of an unwanted Internet sexual solicitation, especially for young males. Future research should focus on parsing out the temporality of events and identifying additional populations of vulnerable youths online.
Gain-Boosting Charge Pump for Current Matching in Phase-Locked Loop

The charge pump (CP) circuit is a key element in a phase-locked loop (PLL). Its function is to transform the Up and Down signals from the phase/frequency detector into current. In CMOS CPs, which have Up and Down switches made of p-channel MOS and n-channel MOS, respectively, a current mismatch occurs when dumping the charge to the loop filter. This current mismatch of the CP in the PLL generates fluctuations in the voltage-controlled-oscillator input and subsequently, a large phase noise on the PLL output signals. In this brief, a new CP with good current matching characteristics is proposed. By using a simple gain-boosting circuit, good current matching characteristics can be achieved with less than 0.1% difference of the Up/Down current over the CP output voltage ranges of 0.8-2.2 V and 0.5-1.2 V on 0.35-mum 3.3-V and 0.18-mum 1.8-V CMOS processes, respectively. The proposed CP circuit is simulated and verified by HSPICE with 0.35-mum 3.3-V and 0.18-mum 1.8-V CMOS parameters
Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management

Sickle cell disease (SCD) is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and vaso‐occlusion leading to a reduced quality of life and life expectancy. Oxidative stress is an important feature of SCD and plays a significant role in the pathophysiology of hemolysis, vaso‐occlusion and ensuing organ damage in sickle cell patients. Reactive oxygen species (ROS) and the (end‐)products of their oxidative reactions are potential markers of disease severity and could be targets for antioxidant therapies. This review will summarize the role of ROS in SCD and their potential implication for SCD management. Am. J. Hematol. 2011. © 2011 Wiley‐Liss, Inc.
First-episode schizophrenia with long duration of untreated psychosis: Pathways to care

Background The early course of illness in first-episode schizophrenia was examined with special emphasis on the duration of untreated psychosis and pathways to care. Method The consecutively admitted individuals (n=34) were assessed on premorbid functioning, duration of untreated psychosis, global functioning, symptoms and social network. To clarify the obstacles for receiving earlier treatment, 17 case histories with long duration of untreated psychosis were intensively studied. Results The duration of untreated psychosis was on average very long (130 weeks), the median value was 54 weeks. The long duration of untreated psychosis group (> 54 weeks) had greater deterioration in the premorbid phase, a weaker social network and were more withdrawn than the short duration of untreated psychosis group (< 54 weeks). The main obstacles for receiving treatment were withdrawal and poor social network. Conclusions In order to identify people earlier, a system of detection must be mobile, easily accessible and attentive to early symptoms of psychosis. It seems to be important to educate the social network related to the individual about the importance of early treatment.
Organization Capital and Expected Returns in Service and Non‐Service Firms: Evidence from Thailand

Organization capital provides firms with competitive advantage, but because of its intangible and movable nature, investors view firms with high organization capital as risker and demand additional risk premia. Similar to Eisfeldt and Papanikolaou (2013), we find that firms in the Stock Exchange of Thailand with highest organization capital earn abnormal returns of 0.75% per month relative to the four‐factor asset pricing model. In addition, we also document that the organization capital risk premium is more relevant for service firms than non‐service ones.
Developmental regulation of the laminin alpha5 chain suggests a role in epithelial and endothelial cell maturation.

We have previously shown that mouse and bovine endothelial cells express a novel 400-kDa laminin alpha chain complexed to beta1 and gamma1 laminin chains. We describe here purification of this laminin isoform from the conditioned medium of a mouse peripheral lymph node endothelial cell line, SVEC. The laminin alpha chain was isolated from the laminin complex, subjected to Edman digestion, and the amino acid sequences of the resulting peptides were determined. Amino acid sequence revealed 100% identity to the predicted amino acid sequence of the recently reported laminin alpha5 gene. A monoclonal antibody to the laminin alpha5 chain was raised (4G6), allowing investigation of its distribution in embryonic, newborn, and mature mouse tissues. The laminin alpha5 chain was expressed mainly by epithelial, endothelial, and myogenic cells: In both embryonic and mature tissues the laminin alpha5 chain was strongly expressed by epithelial cells, the bronchi of the lungs and the developing kidney tubules being the sites of strongest expression. However, laminin alpha5 was not associated with early stages of epithelial cell development, but rather with epithelial cell maturation. Widespread expression of laminin alpha5 in endothelial cells was apparent only in tissues of mature mice, its appearance correlating approximately with sexual maturity. During embryogenesis and in newborn tissues, laminin alpha5 occurred in basement membranes of larger blood vessels only, excluding a role in angiogenic processes. Smooth muscle and skeletal muscle cells were the only other cell types which showed considerable laminin alpha5 expression, with skeletal muscle exhibiting a developmentally regulated pattern of expression: The laminin alpha5 chain occurred in skeletal muscle fiber basement membranes early in embryogenesis (E13-E15) but decreased with development, remaining strongly expressed only at the neuromuscular junction. The data show that laminin alpha5 expression is associated with epithelial and endothelial cell maturation, implicating a role for this laminin chain in the maintenance of differentiated epithelial and endothelial cell phenotype.
Insulin promotes and cyclic adenosine 3',5'-monophosphate impairs functional insertion of insulin receptors in the plasma membrane of rat adipocytes: evidence for opposing effects of tyrosine and serine/threonine phosphorylation.

The aim of the present study was to elucidate events in the plasma membrane (PM) associated with the previously described effect of insulin to rapidly enhance the number of cell surface insulin binding sites in rat adipocytes. [125I]insulin was cross-linked to cell surface insulin receptors of intact cells that had been preincubated with or without insulin. Subsequently prepared PM displayed a approximately 3-fold increase in bound [125I]insulin when cells had been pretreated with 6 nM insulin for 20 min compared to membranes from control cells, and SDS-PAGE with autoradiography showed that this occurred at the insulin receptor alpha-subunit. The magnitude of the effect was similar to that found for insulin binding to intact cells that had been preincubated with insulin. In contrast, the insulin binding capacity in the PM was not affected by prior treatment of cells with insulin when assessed with the addition of [125I]insulin directly to solubilized PM; this suggests an unchanged total number of PM receptors. Thus, the enhancement of cell surface insulin binding capacity produced by insulin is not due to the translocation of receptors, but instead appears to be confined to receptors already present in the PM. The addition of phospholipase C (from Clostridium perfringens), which cleaves PM phospholipids, mimicked the effect of insulin to enhance cell surface binding in adipocytes, and this suggests a pool of cryptic PM receptors. Both the nonmetabolizable cAMP analog N6-monobutyryl cAMP (N6-mbcAMP) and the serine/threonine phosphatase inhibitor okadaic acid abolished the effect of concomitant insulin treatment to increase binding capacity. In contrast, the tyrosine phosphatase inhibitor vanadate increased insulin binding even in the presence of okadaic acid or N6-mbcAMP. The effect of N6-mbcAMP to impair cell surface insulin binding was also evident in the presence of a peptide derived from the major histocompatibility complex type I that effectively impairs receptor internalization, but the amount of PM receptors assessed by immunoblot was unaltered. Taken together, the data suggest that insulin exposure leads to the uncovering of cryptic receptors associated with the PM. It is also suggested that tyrosine phosphorylation promotes this process, whereas enhanced serine phosphorylation, e.g. produced by cAMP, impairs the functional insertion of the receptors, rendering them unable to bind insulin.
Crime Pattern Theory

A broad understanding of crime requires explanations for both the origins of individual and group criminal propensity and when and where criminal events occur. Crime pattern theory provides explanations for the variation in the distribution of criminal events in space and time given a range of different propensities. In the organization of their everyday lives, both occasional and persistent criminals spend most of their time engaged in the same legitimate everyday activities as everyone else. The location of criminal events in space–time are shaped by these everyday activities and the specific criminal’s activity. Occasional and persistent offenders develop activity spaces and awareness spaces. The shape and dynamics of these spaces is influenced by the structures of human settlements that channel and limit movement patterns in time and space. These structures include the built environments and the socioeconomic and cultural environments in which people live, work, or go to school, and in which they spend their social, entertainment, and shopping time. Crime pattern theory utilizes the major components of the built and social environment—activity nodes, paths between nodes, neighborhoods and neighborhood edges, and the socioeconomic backcloth—in conjunction with the routine movements of the population in general to understand crime generator and crime attractor locations and the formation of repeat areas of offending for individuals and groups of offenders as well as more aggregate crime hot spots and cold spots. This information is translated into a geometry of crime that describes the journeys to crime by individual criminal offenders and groups of offenders and their victims or targets. Crime pattern theory explains the process of criminal target search, suggests strategies for crime reduction, and describes potential displacements of criminal events in space and time following changes in the suitability of targets or target locations at particular places and specific times.
A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis

The intracellular pathogen Chlamydia trachomatis possesses a type III secretion (TTS) system believed to deliver a series of effector proteins into the inclusion membrane (Inc-proteins) as well as into the host cytosol with perceived consequences for the pathogenicity of this common venereal pathogen. Recently, small molecules were shown to block the TTS system of Yersinia pseudotuberculosis. Here, we show that one of these compounds, INP0400, inhibits intracellular replication and infectivity of C. trachomatis at micromolar concentrations resulting in small inclusion bodies frequently containing only one or a few reticulate bodies (RBs). INP0400, at high concentration, given at the time of infection, partially blocked entry of elementary bodies into host cells. Early treatment inhibited the localization of the mammalian protein 14-3-3β to the inclusions, indicative of absence of the early induced TTS effector IncG from the inclusion membrane. Treatment with INP0400 during chlamydial mid-cycle prevented secretion of the TTS effector IncA and homotypic vesicular fusions mediated by this protein. INP0400 given during the late phase resulted in the detachment of RBs from the inclusion membrane concomitant with an inhibition of RB to elementary body conversion causing a marked decrease in infectivity.