Miracle-dz/UniFAR-FTUs huggingface dataset:
Implementable Strategies and Exploratory Considerations to Reduce Costs Associated with Anti-TNF Therapy in Inflammatory Bowel Disease

Abstract:A health care system is needed where care is based on the best available evidence and is delivered reliably, efficiently, and less expensively (best care at lower cost). In gastroenterology, anti–tumor necrosis factor agents represent the most effective medical therapeutic option for patients with moderate-to-severe inflammatory bowel disease (IBD), but are very expensive and account for nearly a quarter of the cost of IBD care, representing a major area of present and future impact in direct health care costs. The ImproveCareNow Network, consisting of over 55 pediatric IBD centers, seeks ways to improve the value of care in IBD, curtailing unnecessary costs and promoting better health outcomes through systematic and incremental quality improvement initiatives. This report summarizes the key evidence to facilitate the cost-effective use of anti–tumor necrosis factor agents for patients with IBD. Our review outlines the scientific rationale for initiating cost-reducing measures in anti–tumor necrosis factor use and focuses on 3 implementable strategies and 4 exploratory considerations through practical clinical guidelines, as supported by existing evidence. Implementable strategies can be readily integrated into today's daily practice, whereas exploratory considerations can guide research to support future implementation.
Angiostrongylus cantonensis: a review of its distribution, molecular biology and clinical significance as a human pathogen

SUMMARY Angiostrongylus cantonensis is a metastrongyloid nematode found widely in the Asia-Pacific region, and the aetiological agent of angiostrongyliasis; a disease characterized by eosinophilic meningitis. Rattus rats are definitive hosts of A. cantonensis, while intermediate hosts include terrestrial and aquatic molluscs. Humans are dead-end hosts that usually become infected upon ingestion of infected molluscs. A presumptive diagnosis is often made based on clinical features, a history of mollusc consumption, eosinophilic pleocytosis in cerebral spinal fluid, and advanced imaging such as computed tomography. Serological tests are available for angiostrongyliasis, though many tests are still under development. While there is no treatment consensus, therapy often includes a combination of anthelmintics and corticosteroids. Angiostrongyliasis is relatively rare, but is often associated with morbidity and sometimes mortality. Recent reports suggest the parasites’ range is increasing, leading to fatalities in regions previously considered Angiostrongylus-free, and sometimes, delayed diagnosis in newly invaded regions. Increased awareness of angiostrongyliasis would facilitate rapid diagnosis and improved clinical outcomes. This paper summarizes knowledge on the parasites’ life cycle, clinical aspects and epidemiology. The molecular biology of Angiostrongylus spp. is also discussed. Attention is paid to the significance of angiostrongyliasis in Australia, given the recent severe cases reported from the Sydney region.
Species-Mediated p53 Activation B and Reactive Oxygen k NF-Intronic Regulation of DR5: Involvement of TRAIL-Induced Apoptosis through the Proteasome Inhibitors Enhance

Manipulation of TRAIL receptor 2 (DR5) pathway is a promising therapeutic strategy to overcome TRAIL-resistant lung cancer cells. Preclinical studies have shown that proteasome inhibitors enhance TRAIL-induced apoptosis in lung cancer cells, but the underlying mechanism has not been fully elucidated. In this study, we demonstrated the enhancement of TRAIL-mediated apoptosis in human alveolar epithelial cells by proteasome inhibitors that up-regulate DR5 expression. This effect was blocked by DR5-neutralizing Ab. Using reporter assay, we demonstrated that the p53 and NF- (cid:1) B elements on the DR5 ﬁrst intron region were involved in proteasome inhibitor-induced DR5 expression. Both p53 small interfering RNA and NF- (cid:1) B inhibitor suppressed DR5 expression, strengthening the signiﬁcance of p53 and NF- (cid:1) B in DR5 transcription. The protein stability, Ser 392 phosphorylation and Lys 373 /Lys 382 acetylation of p53 were enhanced by MG132. In addition to p53, I (cid:1) B (cid:2) degradation and NF- (cid:1) B translocation was also observed. Moreover, the binding of p53 and p65 to the ﬁrst intron of DR5 was demonstrated by DNA afﬁnity protein-binding and chromatin immunoprecipitation assays. Intracellular reactive oxygen species (ROS) generation after MG132 treatment contributed to p53, but not p65 nuclear translocation and DNA-binding activity. ROS scavenger dramatically inhibited the apoptosis induced by proteasome inhibitors plus TRAIL. The p53-null H1299 cells were resistant to proteasome inhibitor-induced DR5 up-regulation and enhancement of TRAIL-induced apoptosis. These ﬁndings reveal that proteasome inhibitor-mediated NF- (cid:1)
Review of orofacial considerations of systemic sclerosis or scleroderma with report of analysis of 3 cases

Scleroderma (skleros; hard, and derma; skin), is currently known as systemic sclerosis due to its progressive nature and widespread tissue involvement. It is a rare connective tissue disorder with a wide range of oral manifestations. Thickening of the skin is the hallmark of the disease. The patient education for self-care and multidisciplinary approach would be needed to manage the condition. The article presents the review of orofacial considerations in scleroderma with a report of analysis of orofacial manifestations 3 cases.
Hsp90 Chaperone Activity Requires the Full-length Protein and Interaction among Its Multiple Domains*

Hsp90 is an abundant and ubiquitous protein involved in a diverse array of cellular processes. Mechanistically we understand little of the apparently complex interactions of this molecular chaperone. Recently, progress has been made in assigning some of the known functions of hsp90, such as nucleotide binding and peptide binding, to particular domains within the protein. We used fragments of hsp90 and chimeric proteins containing functional domains from hsp90 or its mitochondrial homolog, TRAP1, to study the requirements for this protein in the folding of firefly luciferase as well as in the prevention of citrate synthase aggregation. In agreement with others who have found peptide binding and limited chaperone ability in fragments of hsp90, we see that multiple fragments from hsp90 can prevent the aggregation of thermally denatured citrate synthase, a measure of passive chaperoning activity. However, in contrast to these results, the luciferase folding assay was found to be much more demanding. Here, folding is mediated by hsp70 and hsp40, requires ATP, and thus is a measure of active chaperoning. Hsp90 and the co-chaperone, Hop, enhance this process. This hsp90 activity was only observed using full-length hsp90 indicating that the cooperation of multiple functional domains is essential for active, chaperone-mediated folding.
Advergaming - A New Breed of Computer Games

With the rise of computer games as a major commercial industry, advertising firms have begun to use them to promote their brands. This new medium is known as advergaming. An advergame is a computer game that contains advertising. Over a period of four months, five online computer games were developed as advergames. This was used to examine this new departure for games. Traditional games were examined to see how they could be used for branding purposes. Differences to how the game development process changes were also investigated. The viability of Java as a development language for advergames was reviewed. It was concluded that games are a viable vehicle for branding, but that advergames require focus groups to guide development. Computer games are potentially a powerful advertising medium that can be implemented with relatively modest technical skills. Java was a suitable development language but may be restricted in the future.
Illocutionary Acts on Liz Gilbert's Dialogue in Eat Pray Love Movie

This thesis deals with the type of illocutionary acts on Liz Gilbert’s dialogue in Eat Pray Love movie. The objectives of the study were to describe the types of illocutionary acts used by Liz Gilbert in Eat Pray Love movie, the dominant type of illocutionary acts used by Liz Gilbert in Eat Pray Love movie and the reason why the dominant type of illocutionary acts occur on Liz Gilbert’s dialogue in Eat Pray Love movie. This research was conducted by using descriptive qualitative design. Descriptive qualitative research is descriptive in that the researcher is interested in the process of meaning and understanding gained through words or picture (Hancock 2007:7). This research used descriptive qualitative research because the intention of this study was to describe how illocutionary used in the movie.The data were the transcript of Liz Gilbert’s dialogue. The findings showed that there were 466 utterances which contained five types of illocutionary acts, namely: Representatives 198 utterances (42.49%), Directives 169 utterances (36.27%), Expressives 89 utterances (19.10%), Commisives 9 utterances (1.93%) and Declarations 1 utterance (0.21%). The most dominant type of illocutionary act was Representatives with total number 198 utterances (42.49%) because Liz Gilbert as the main character often described and informed about the situation of her journey and experience when she visited Italy, India and Indonesia where she finally found the balance of life, true love and happiness.
Impact of out-of-hours admission on patient mortality: longitudinal analysis in a tertiary acute hospital

Background Emergency hospital admission on weekends is associated with an increased risk of mortality. Previous studies have been limited to examining single years and assessing day—not time—of admission. We used an enhanced longitudinal data set to estimate the ‘weekend effect’ over time and the effect of night-time admission on all-cause mortality rates. Methods We examined 246 350 emergency spells from a large teaching hospital in England between April 2004 and March 2014. Outcomes included 7-day, 30-day and in-hospital mortality rates. We conducted probit regressions to estimate the impact on the absolute difference in the risk of mortality of two key predictors: (1) admission on weekends (19:00 Friday to 06:59 Monday); and (2) night-time admission (19:00 to 06:59). Logistic regressions were used to estimate ORs for relative mortality risk differences. Results Crude 30-day mortality rate decreased from 6.6% in 2004/2005 to 5.2% in 2013/2014. Adjusted mortality risk was elevated for all out-of-hours periods. The highest risk was associated with admission on weekend night-times: 30-day mortality increased by 0.6 percentage points (adjusted OR: 1.17, 95% CI 1.10 to 1.25), 7-day mortality by 0.5 percentage points (adjusted OR: 1.23, 95% CI 1.12 to 1.34) and in-hospital mortality by 0.5 percentage points (adjusted OR: 1.14, 95% CI 1.08 to 1.21) compared with admission on weekday daytimes. Weekend night-time admission was associated with increased mortality risk in 9 out of 10 years, but this was only statistically significant (p<0.05) in 5 out of 10 years. Conclusions There is an increased risk of mortality for patients admitted as emergencies both on weekends and during the night-time. These effects are additive, so that the greatest risk of mortality occurs in patients admitted during the night on weekends. This increased risk appears to be consistent over time, but the effects are small and are not statistically significant in individual hospitals in every year.
Auto-inhibition of the Dbl Family Protein Tim by an N-terminal Helical Motif*

Dbl-related oncoproteins are guanine nucleotide exchange factors specific for Rho-family GTPases and typically possess tandem Dbl homology (DH) and pleckstrin homology domains that act in concert to catalyze exchange. Because the ability of many Dbl-family proteins to catalyze exchange is constitutively activated by truncations N-terminal to their DH domains, it has been proposed that the activity of Dbl-family proteins is regulated by auto-inhibition. However, the exact mechanisms of regulation of Dbl-family proteins remain poorly understood. Here we show that the Dbl-family protein, Tim, is auto-inhibited by a short, helical motif immediately N-terminal to its DH domain, which directly occludes the catalytic surface of the DH domain to prevent GTPase activation. Similar to the distantly related Vav isozymes, auto-inhibition of Tim is relieved by truncation, mutation, or phosphorylation of the auto-inhibitory helix. A peptide comprising the helical motif inhibits the exchange activity of Tim in vitro. Furthermore, substitutions within the most highly conserved surface of the DH domain designed to disrupt interactions with the auto-inhibitory helix also activate the exchange process.
Übertrager und Leistungselektronik in induktiven Energieübertragungssystemen zur Ladung von Elektrofahrzeugen

Induktive Energieubertragungssysteme zur Ladung von Elektrofahrzeugen werden seit vielen Jahren intensiv erforscht. Sie weisen gegenuber konventionellen kabelgebundenen Ladesystemen Vorteile hinsichtlich Komfort, Sicherheit und Zuverlassigkeit auf. Nachteilig ist hingegen der grosere Bauteilaufwand sowie die geringere Effizienz des Gesamtsystems. Die Zielstellung dieser Arbeit ist, unter Anwendung aktueller wissenschaftlicher Methoden, Moglichkeiten zur Steigerung der Energieeffizienz induktiver Ladesysteme fur Elektrofahrzeuge zu untersuchen. Des Weiteren sollen allgemeingultige Konzepte und Masnahmen zur Auslegung induktiver Ladesysteme erarbeitet werden. Im Fokus der Betrachtung stehen der Ubertrager und die Leistungselektronik. Die Verifizierung der vorgeschlagenen Konzepte und analytischen Ergebnisse erfolgt exemplarisch anhand eines induktiven Ladesystems mit einer Nennleistung von 6 kW, das fur ein Flurforderzeug mit einer Niedervoltbatterie (24 V / 48 V) ausgelegt und experimentell im Labor untersucht wird.
Improving RRT motion trajectories using VFM

This paper presents a new method to improve the trajectories based in the Voronoi Fast Marching Method (VFM). It can be used to improve the smoothness and the length of the trajectories calculated with probabilistic methods with bad quality trajectories such as RRT or PRM. This way, it is possible to get the good properties of the RRT method as the fact that it can work in many dimensions with the good properties of VFM method. This method is very fast and reliable and the trajectories are similar to the human trajectories: smooth and not very close to obstacles and walls.
Interactive Volume Illustration Using Intensity Filtering

We propose a simple and interactive technique for volume illustration by using the difference between the original intensity values and a low-pass filtered copy. This difference, known as unsharped mask, provides us with a spatial importance map that captures salient and separability information about regions in the volume. We integrate this map in the visualization pipeline and use it to modulate the color and the opacity assigned by the transfer function to produce different illustrative effects. We also apply stipple rendering modulating the density of the dots with the spatial importance map. The core of our approach is the computation of a 3D Gaussian filter, which is equivalent to three consecutive 1D filters. This separability feature allows us to obtain interactive rates with a CUDA implementation. We show results of our approach for different data sets.
Hemoglobin Agenogi - A rare abnormal beta globin chain variant

Haemoglobin (Hb) Agenogi is clinically asymptomatic, rare β-globin chain variant characterized by a substitution of glutamic acid by lysine at position 90 of β-chain. It elutes in the C-window on high-performance liquid chromatography (HPLC). We report a 10-year-old male with easy fatigability, lethargy, pallor, and mild splenomegaly. Hematological parameters revealed microcytic hypochromic anemia and mildly raised red blood cells count, suggestive of thalassemia trait. On HPLC, a predominant peak was observed in the C-window (82.6%) along with raised HbA 2 level (9.3%). Based on these findings, a possibility of HbC disease/β-thalassemia trait doubly heterozygous was considered. Family studies were advised. HPLC findings in father were suggestive of β-thalassemia trait, while both his mother and brother had an abnormal peak in the C-window of 42.7% and 40.8%, respectively, with elevated HbA 2 values of 5% and 4.9%, respectively. Direct DNA sequencing revealed intervening sequences 1-5 (G ; C) in father, confirming β-thalassemia trait. His mother and brother had heterozygous gene mutation at codon 90 of β-globin chain (G ; A) suggestive of Hb Agenogi. The child carried mutations for both β-thalassemia trait as well as Hb Agenogi.
Data Management for Interactive Game Database

An interactive game needs to call for multimedia data quickly for its real time and interactivity features. Its data is composed of pictures, sounds and action scripts as game roles stored on disks. Therefore, a special database management system plays important role, serving the back end for interactive games. Such a system is introduced in the paper and a relational model is built as well. Based on this model, a method to store and manage multimedia data by hash from two aspects, physical storage and logic semantic, is studied, providing more efficient query processing and better performance.
Incorporation of tritium-labeled thymidine by rabbit corneal endothelium.

Introduction The problem of regeneration and replacement of corneal endothelial cells is still unsolved. It is generally held that there is no evidence of mitosis in the endothelium of adult animals, 1-4 although mitoses have been observed in young cats, 1 and recently von Sallmann 5 has reported a mitotic index of 2/100,000 in "young adult rabbits. " Binder and Binder described only "amitotic" cell division in uninjured rabbit endothelium but both "mitotic and amitotic cell division" in the endothelium 12 hours after injury with a blunt spatula. 3 Following irrigation of the anterior chamber by α-chymotrypsin, von Sallmann observed greatly increased mitotic activity in some localized areas of Descemet's endothelium. Harding et al. have recently shown that the very weak β-radiation from tritiated thymidine can be detected, by means of autoradiography, in whole-mount preparations of lens epithelium. 6 By this method, incorporation of tritiated thymidine by any cell in the
Multipole expansions in four-dimensional hyperspherical harmonics

The technique of vector differentiation is applied to the problem of the derivation of multipole expansions in four-dimensional space. Explicit expressions for the multipole expansion of the function with r = r1 + r2 are given in terms of tensor products of two hyperspherical harmonics depending on the unit vectors and . The multipole decomposition of the function (r1 r2)n is also derived. The proposed method can be easily generalized to the case of the space with dimensionality larger than four. Several explicit expressions for the four-dimensional Clebsch–Gordan coefficients with particular values of parameters are presented in the closed form.
Safe and effective carbon dioxide laser skin resurfacing of the neck

CO2 laser skin resurfacing remains the gold standard for treatment of photoaged facial skin. It can be used onto the neck to further blend in the treated area with non‐treated, adjacent photodamaged skin as well as improve the superficial textural quality of the neck skin. This article provides an overview of laser skin resurfacing of the neck, including pre‐operative evaluation, patient education and selection, laser settings and technique used, post‐operative care, and identification and treatment of possible complications. Lasers Surg. Med. 38:653–657, 2006. © 2006 Wiley‐Liss, Inc.
CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival

Objectives: We hypothesized that CSF neurofilament light (NFL) levels would be elevated in dementias with subcortical involvement, including vascular dementia (VaD), but less elevated in dementias primarily affecting gray matter structures, such as Alzheimer disease (AD), and that elevated CSF NFL would correlate with disease severity and shorter survival time irrespective of clinical diagnosis. Methods: We included 3,356 individuals with dementia who had CSF NFL analyzed in our laboratory between 2005 and 2012. Clinical diagnoses and Mini-Mental State Examination (MMSE) scores were obtained from the Swedish Dementia Registry, and in selected cases (n = 478), date of death from the Swedish Mortality Registry. Results: CSF NFL differed among clinical diagnoses, with the highest levels seen in frontotemporal dementia, VaD, and mixed AD and VaD. Early-onset AD (younger than 65 years) had the lowest levels. High CSF NFL correlated with low MMSE score and short survival time irrespective of diagnosis, and was also particularly evident in AD. Conclusions: CSF NFL differs among different neurodegenerative diseases and is especially high in dementias engaging subcortical brain regions, such as VaD and mixed AD and VaD, but also in frontotemporal dementia. The association of high CSF NFL levels with disease severity and short survival supports the notion that high CSF NFL levels indicate more aggressive disease processes.
Algorithm to trade off between utility and privacy cost of online social search

Online social search such as Quora and Zhihu brings new ways to obtain answers to questions in social networks. However, personal and other sensitive information may be exposed to others when the question spreads via the social network. People obtain utility when they obtain answers to their questions but may suffer privacy cost when their personal information is known by others. Researchers are seeking methods and tools to help users get utility and protect their privacy at the same time. In this paper, we study this problem by proposing a framework to quantitatively evaluate the utility and privacy cost in online social search. Besides, we design an algorithm under our framework to help users trade off their utility and privacy cost. Simulations are performed to illustrate the concepts in our framework and demonstrate the advantages of our algorithm.
Cavity ring-down spectroscopy sensor for detection of hydrogen chloride

Abstract. A laser-based cavity ring-down spectroscopy (CRDS) sensor for measurement of hydrogen chloride (HCl) has been developed and characterized. The instrument uses light from a distributed-feedback diode laser at 1742 nm coupled to a high finesse optical cavity to make sensitive and quantifiable concentration measurements of HCl based on optical absorption. The instrument has a (1σ) limit of detection of
A Kalman Filter-Based Method for Real-Time Tracking of I/Q Impairments in Digital Communication Transmitters

Impairments affecting the baseband modulator of digital transmitters, commonly named I/Q impairments, are responsible for deviations of symbols on the I/Q plane from their original position. They consequently cause a reduction of noise margin and can ultimately increase the probability of error. This is the reason why their evaluation is so important in troubleshooting and testing activities. The paper presents an original method for I/Q impairments evaluation, which is based on discrete extended Kalman filter. The proposed method grants as accurate measurement results as alternative solutions present in the literature, but differently from them, it also permits continuous monitoring of active transmitters through real-time tracking of the aforementioned impairments. The results of several experiments carried out on laboratory signals to assess the performance of the method are presented.