Miracle-dz/UniFAR-FTUs huggingface dataset:
Evidence for reduced magnetic braking in polars from binary population models

We present the first population synthesis of synchronous magnetic cataclysmic variables, called polars, taking into account the effect of the white dwarf (WD) magnetic field on angular momentum loss. We implemented the reduced magnetic braking (MB) model proposed by Li, Wu & Wickramasinghe into the Binary Stellar Evolution (bse) code recently calibrated for cataclysmic variable (CV) evolution. We then compared separately our predictions for polars and non-magnetic CVs with a large and homogeneous sample of observed CVs from the Sloan Digital Sky Survey. We found that the predicted orbital period distributions and space densities agree with the observations if period bouncers are excluded. For polars, we also find agreement between predicted and observed mass transfer rates, while the mass transfer rates of non-magnetic CVs with periods ≳3 h drastically disagree with those derived from observations. Our results provide strong evidence that the reduced MB model for the evolution of highly magnetized accreting WDs can explain the observed properties of polars. The remaining main issues in our understanding of CV evolution are the origin of the large number of highly magnetic WDs, the large scatter of the observed mass transfer rates for non-magnetic systems with periods ≳3 h, and the absence of period bouncers in observed samples.
Periimplantitis y mucositis periimplantaria. Factores de riesgo, diagnóstico y tratamiento

espanolIntroduccion: El objetivo de este trabajo es profundizar en el conocimiento de la enfermedad periimplantaria y los tratamientos existentes descritos en la literatura. Material y metodo: Revision bibliografica de las enfermedades periimplantarias, basada en una busqueda en bases de datos Pubmed, Medline y Cochrane Library, utilizando como palabras clave "periimplantitis, mucositis, tabaquism, oral microbiota, occlusal overload, surgical treatment, antimicrobial therapy, detoxification, regenerative therapy, bone defects". Desarrollo y discusion: Analisis de los factores de riesgo, el diagnostico y el tratamiento de las enfermedades periimplantarias. Conclusiones: Los factores como el tabaco o una historia de periodontitis, junto con una mala higiene oral, son las principales causas de las enfermedades periimplantarias. Un correcto diagnostico de la etiologia, asi como, la adecuada eleccion de la terapeutica, pueden detener el avance de la enfermedad periimplantaria. Tras el tratamiento realizado, sera muy importante el control periodico y el mantenimiento de una correcta higiene oral. EnglishIntroduction: The aim of this paper is to deepen the knowledge of peri-implant disease and existing treatments described in the literature. Material and methods: Literature review of peri-implant disease based on a search in databases like PubMed and Medline using keywords "periimplantitis, mucositis, tabaquism, oral microbiota, occlusal overload, surgical treatment, antimicrobial therapy, detoxification, regenerative therapy, bone defects". Development and discussion: Analysis of risk factors, diagnosis and treatment of peri-implant disease. Conclusions: Factors such as tabaquism or a history of periodontitis, along with poor oral hygiene are the main causes of peri-implant disease. A correct diagnosis of the cause and the appropriate choice of therapy may stop the progression of peri-implant disease. Following treatment done, it will be very important to do the periodic controls and maintenance of proper oral hygiene.
Problem-Based Learning: An Approach to Medical Education

When there are many people who don't need to expect something more than the benefits to take, we will suggest you to have willing to reach all benefits. Be sure and surely do to take this problem based learning an approach to medical education that gives the best reasons to read. When you really need to get the reason why, this problem based learning an approach to medical education book will probably make you feel curious.
Artritis reumatoide tratada con inhibidores del factor de necrosis tumoral α (Anti-TNF-α) y tuberculosis pulmonar

Presentacion de una paciente con artritis reumatoide severa en tratamiento con inhibidores del Factor de Necrosis Tumoral (Anti-TNF), quien presenta ademas un cuadro de tuberculosis pulmonar. La artritis reumatoide es una enfermedad inflamatoria cronica de las articulaciones, que afecta en un inicio la membrana sinovial, pero que si no es tratada oportunamente lleva a dano estructural irreversible del sistema musculo-esqueletico y eventualmente de otros sistemas organicos. Dentro de los criterios de la American College of Rheumatology se incluyen la Rigidez Matutina, Artritis de 3 o mas articulaciones, Artritis simetrica, Nodulos reumaticos, Factor Reumatoideo y hallazgos radiograficos. Dentro de la patogenia de esta enfermedad, el Factor de Necrosis Tumoral es una citocina que juega un papel importante, una produccion elevada de TNF-α se ha encontrado en la sinovial de estos pacientes, y por su capacidad de inducir la produccion de otras citocinas, como IL-6, IL-17, GM-CSF, M-CSF, e incluso IL-1 y TNF-α (funcion autocrina), pareceria que el TNF-α ejerce una accion “jerarquica” dentro de la llamada red de citocinas y una inhibicion de su accion da como resultado un beneficio terapeutico en los pacientes con AR. Sin embargo, es conocido que la infeccion concurrente mas frecuentemente informada con el uso de agentes biologicos (Anti-TNF) es la TB, y la incidencia de esta se ha incrementado desde el advenimiento de la terapia biologica. Por tanto, la descripcion de este caso no corresponde a un hecho medico aislado, sino a una problematica actual y real. Este es el primer caso que se reporta en la Costa Caribe
The Transition to Smoking Cessation: Evidence from Multiple Failure Duration Analysis

While much is known about the impacts prices and tobacco control policies have on smoking participation and frequency of cigarette use, little is known about their impacts on smoking cessation. This paper addresses the dynamics of smoking cessation using longitudinal data on young adults from the Monitoring the Future Surveys. Site-specific prices and several measures of clean indoor air restrictions are added to the survey data. Both parametric and semi-parametric duration models are used to model multiple cessation attempts of young adults. The estimates indicate that increases in the price of cigarettes increase the probability of initial smoking cessation as well as subsequent cessation for those individuals who are unable to remain smoke- free after at least one prior cessation attempt. The average price elasticity of cessation is 0.343. In addition, stronger restrictions on smoking in private worksites and public places other than restaurants increase the probability of young adult smoking cessation.
Rehabilitation of patients with chronic obstructive lung disease

La rehabilitation pulmonaire est une intervention transdisciplinaire et structuree destinee aux patients atteints de bronchopneumopathie chronique obstructive (BPCO), qui peut reduire la dyspnee et ameliorer l'intolerance a l'exercice et la qualite de vie. Cette intervention presente un rapport de cout/efficacite favorable ; elle diminue en effet l'utilisation des soins de sante. Le reentrainement a l'effort est un element essentiel dans tout programme de rehabilitation pulmonaire. Pour obtenir des effets substantiels, on recommande de prescrire un reentrainement supervise, a haute intensite, trois a cinq fois par semaine, avec des sessions ayant une duree de 30 a 45 minutes. Un minimum de 20 sessions est recommande. Des programmes comprenant un nombre plus important de sessions menent a des effets plus prononces et prolonges. Un programme d'education visant une meilleure connaissance de la maladie et de la prise en charge par le patient meme d'une exacerbation de BPCO, peut diminuer le nombre d'hospitalisations. Une intervention nutritionnelle doit etre prise en consideration chez les patients presentant une denutrition ou une diminution de la masse musculaire. Les patients anxieux peuvent beneficier d'un support psychosocial, tandis que l'integration d'une prise en charge ergotherapeutique peut promouvoir l'autonomie du patient dans ses activites quotidiennes et reduire son isolement. Tout programme de rehabilitation pulmonaire devrait etre de preference ambulatoire. Les programmes en hospitalisation doivent etre reserves aux patients presentant des problemes de transports ou un deconditionnement severe. Les effets les plus convaincants d'un programme de rehabilitation pulmonaire organise au domicile du patient ont ete observes dans le contexte d'une maintenance des benefices obtenus apres un programme ambulatoire.
Testing the importance of cleansing procedures for overlaps inadministrative data : first evidence for Germany

"Process-generated and administrative datasets have become increasingly important for labour market research over the past ten years. Major advantages of this data are large sample sizes, absence of retrospective gaps and unit non-responses. Nevertheless, the quality and validity of the information remain unclear. This paper contributes to this subject, focusing on the variation of research results due to alternative data cleansing procedures. In particular, the paper uses the general set up for data cleaning proposed by Wunsch/Lechner (2008) in evaluating the outcome of training programmes in Germany. First results are limited to the sensitivity of the construction of the sample populations used for the counterfactual analysis. The results emphasize that sample construction seems to be robust to the scenario used for the data cleansing. " (Author's abstract, IAB-Doku) ((en))
Alterações clínicas,hematológicas e sorológicas de cães infectados por Ehrlichia canis

MANOEL, C. S. Clinical, hematologic and serological changes in dogs infected by Ehrlichia canis. [Alteracoes clinicas, hematologicas e sorologicas de caes infectados por Ehrlichia canis]. 2010. 65f. Dissertacao (Mestrado em Ciencias) – Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Sao Paulo, 2010. The canine monocytic ehrlichiosis (CME) is an infectious disease occurring worldwide and is transmitted by the tick Rhipicephalus sanguineus. The clinical manifestations are nonspecific and multisystemic. It may present acute, asymptomatic and chronic phases, which may be presented with haematological changes such as thrombocytopenia, mild anemia and leukopenia during the acute phase, mild thrombocytopenia in asymptomatic phase, and pancytopenia in severe chronic cases. The establishment of prognostic indicators for the disease may be of great value to guide clinical treatment. The study of antibodies titer in infected dogs could help in the diagnosis of CME and in monitoring treatment. In order to identify the main clinical, hematological and serological changes in dogs infected with E. canis, 82 animals were selected with etiologic diagnosis of a CME (positive to Polymerase Chain Reaction PCR). The dogs were subdivided into groups of asymptomatic animals (n = 12), sick and survivors (n = 51) and sick and non-survivors (n = 19). It was also conducted clinical, hematological and serological monitoring of 28 animals treated with recommended medication for the period until 180 days after treatment. In clinical analysis, there was no racial or sexual predisposition, however dogs older than 8 years of age had a higher frequency. The most frequently reported symptoms in all dogs except the asymptomatic patients were pale mucous membranes, apathy, appetite loss, lethargy and gastroenteritis. Hematological changes found in the group of sick dogs were anemia and thrombocytopenia, which varied only in intensity when comparing the survivors to the nonsurvivors, but only anemia and leukopenia were presented as negative prognostic factors for the disease. High titers of antibodies (2560 ≥) were observed in most infected animals, but they could not be considered indicators of persistent infection. In two out of the 28 monitored animals after treatment there was reinfection, compared to positive results back on the research of genetic material to E.canis, associated with relapse of hematological changes in one of the two animals, and sudden new increase in antibody titer. In other animals, despite the rapid rise of the concurrent title of relapse hematological changes, there was no erliquial DNA amplification, suggesting molecular diagnostic to be false negative. It was concluded that clinical and hematologic changes suggestive of the disease were found in sick animals, only anemia and leukopenia may be prognostic indicators of the disease, and that the interpretation of antibody titers should be done in line with clinical and hematologic changes of the suspect dog.
Pancytopenia in two horses following administration of potentiated sulfonamide antimicrobials

Summary Adverse drug reactions to potentiated sulfonamide antimicrobial drug combinations have been reported in many species, including horses. This report describes the occurrence of pancytopenia in 2 horses, one subsequent to an immune mediated reaction and the other bone marrow aplasia following the administration of trimethoprim and sulfadimidine. These cases highlight the importance of judicious use of antimicrobial agents and describe adverse drug reactions in horses receiving potentiated sulfonamide antimicrobials.
EFFECT OF CHILDHOOD FOOD HABIT AND PHYSICAL ACTIVITIES ON HEALTH OF THEIR OLD AGE

An attempt has been made to study the correlation between the childhood food habit and its impact on the health status in their adulthood. Those who were accustomed to fabricated food items in childhood were prone to fatal diseases like diabetes, heart ailments, obesity, kidney problems etc. in their adulthood. The population which indulged more in fabricated foods resided in urban areas than in rural areas.
An Intelligent Data Analysis for Hotel Recommendation Systems using Machine Learning

This paper presents an intelligent approach to handle heterogeneous and large-sized data using machine learning to generate true recommendations for the future customers. The Collaborative Filtering (CF) approach is one of the most popular techniques of the RS to generate recommendations. We have proposed a novel CF recommendation approach in which opinion based sentiment analysis is used to achieve hotel feature matrix by polarity identification. Our approach combines lexical analysis, syntax analysis and semantic analysis to understand sentiment towards hotel features and the profiling of guest type (solo, family, couple etc). The proposed system recommends hotels based on the hotel features and guest type as additional information for personalized recommendation. The developed system not only has the ability to handle heterogeneous data using big data Hadoop platform but it also recommend hotel class based on guest type using fuzzy rules. Different experiments are performed over the real world dataset obtained from two hotel websites. Moreover, the values of precision and recall and F-measure have been calculated and results are discussed in terms of improved accuracy and response time, significantly better than the traditional approaches.
Facebook AI’s WAT19 Myanmar-English Translation Task Submission

This paper describes Facebook AI’s submission to the WAT 2019 Myanmar-English translation task. Our baseline systems are BPE-based transformer models. We explore methods to leverage monolingual data to improve generalization, including self-training, back-translation and their combination. We further improve results by using noisy channel re-ranking and ensembling. We demonstrate that these techniques can significantly improve not only a system trained with additional monolingual data, but even the baseline system trained exclusively on the provided small parallel dataset. Our system ranks first in both directions according to human evaluation and BLEU, with a gain of over 8 BLEU points above the second best system.
Modulators of bleeding tendency in severe factor V deficiency

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Characterisation of inflammation and pain thresholds to mechanical stimulation in dairy cows with clinical mastitis and the effect of treatment with meloxicam

Recognition, alleviation and control of pain are central to ensuring good welfare in food producing animals. An intervention trial was conducted on 117 dairy cows with naturally-occurring, mild or moderate, clinical mastitis in a single quarter in order to investigate the effect of the administration of the non-steroidal anti-inflammatory drug, meloxicam (Metacam, Boehringer Ingelheim Animal Health GmbH) used in conjunction with an intramammary antibiotic infusion of cefquinome (Cephaguard LC Intramammary, Intervet UK Limited, Milton Keynes). Clinical and laboratory parameters were investigated to assess their usefulness as objective markers of pain. Measuring the cows’ response to a mechanical stimulus assessed altered pain processing. Heart rates, respiratory rates and rectal temperatures of cows were higher in moderate cases compared to milk cases of clinical mastitis (p 0.05). On bacteriological examination to the recruited cases, 30% of isolates yielded S uberis, 24% yielded no growth, 22% E coli, 11% Staph aureus, six per cent other microbiological species, four per cent A pyogenes and three per cent S dysgalactiae. When compared with mild cases of mastitis the moderate cases had a greater proportion of isolations of S uberis (p<0.01) and a smaller proportion of no growths (p<0.01). There was no effect of mastitis on the fat percentage of milk, as judged by the comparison of affected quarters to diagonally opposite quarters and to normal cows. The protein content of milk increased with mastitis and the lactose content decreased. The most common somatic cell type in quarters affected with mild and moderate mastitis on the day of recruitment to the study were polymorphonuclear cells, whereas large mononuclear cells were the predominant cell type in normal animals. The concentration of haptoglobin in milk from the affected quarters of cows with moderate mastitis was greater (p<0.01) than that in milk from affected quarter of cows with mild mastitis. Mammary-associated serum amyloid A concentrations were higher in the affected quarter of cases of milk and moderate clinical mastitis than in normal cows (p<0.001). Concentrations of the inflammatory mediator, prostaglandin E2 in milk were lower in mild cases of clinical mastitis compared to moderate cases (p<0.05). In conclusion, physiological and laboratory parameters may serve as indicators of clinical mastitis, help differentiate between different severities of clinical mastitis and, therefore, aid in appropriate targeting of therapy.
Pharmacological targeting of neutrophilic airway inflammation in COPD

Background: COPD is characterised by increased neutrophilic inflammation which further increases during exacerbations. Corticosteroids are currently one of the mainstays of treatment but they have limited effectiveness; there is a great need to develop new anti-inflammatory pharmacotherapies for use in COPD. Inhaled LPS has been used as a model of increased neutrophilic inflammation in healthy patients, smokers and asthmatics. Its use in patients with COPD as a model of exacerbations has not yet been evaluated. PI3 kinase is a vital intracellular enzyme, which upon activation leads to a number of cellular processes; the ? and ? isoforms of the enzyme are of particular importance in leucocyte migration, development and activation. There is increasing evidence for upregulation of this pathway in COPD.Aims: (1) To test the safety of the use of inhaled LPS in patients with COPD for use as a model of exacerbation and to investigate the systemic and airway inflammatory response in vivo. (2) To investigate the action of PI3 kinase enzyme inhibitors and dexamethasone in vitro on neutrophilic inflammation in COPD patients during the stable state and exacerbations.Methods: (1) 12 patients with mild to moderate COPD inhaled 5�g LPS; safety measurements and airway and systemic biomarkers were collected up to 24 hours post inhalation. (2) The effect of PI3 kinase enzyme inhibitors and dexamethasone on MMP-9 and ROS release from peripheral and airway neutrophils from stable COPD and exacerbations was examined in vitro. The effect of PI3 kinase enzyme inhibitors and dexamethasone on cytokine release from peripheral neutrophils from stable COPD patients was also investigated. Results: (1) Inhaled LPS (5�g) caused a significant fall in FEV1 and increase in sputum neutrophil numbers. There was an associated increase in systemic IL-6, CRP and CC-16, all with differing temporal patterns. No patients reported any significant symptoms. (2) PI3 kinase enzyme inhibitors significantly reduced MMP-9 and ROS release from airway and peripheral neutrophils from COPD patients in the stable state and during exacerbations; dexamethasone had minimal effect. Cytokine release from peripheral neutrophils from COPD patients in the stable state was also significantly inhibited by PI3 kinase enzyme inhibitors and dexamethasone.Conclusions: (1) Inhaled LPS in patients with COPD is a safe model to induce acute on chronic neutrophilic inflammation and therefore could be used as a model to study COPD exacerbations. (2) PI3 kinase enzyme inhibitors reduce COPD neutrophil MMP-9, ROS and cytokine release in vitro and are therefore are a promising new anti-inflammatory pharmacotherapy.
The Role of Podocyte Prostaglandin E2 and Angiotensin II Receptors in Glomerular Disease

ii LIST OF FIGURES . vii LIST OF ABBREVIATIONS . ix ACKNOWLEDGMENTS . xv CHAPTER 1 – INTRODUCTION . 1 1.1 Chronic kidney disease. 2 1.2 Glomerular structure and function . 4 1.3 Podocyte structure and function . 6 1.4 Prostanoid signaling in the podocyte . 11 1.6 p38 mitogen activated protein kinase . 18 1.7 The Renin angiotensin system. 19 1.8 Rationale. 24 1.9 Objectives . 25 1.10 Hypothesis . 26 1.10 Relevance . 27 1.11 Thesis content . 28 CHAPTER 2 – MATERIALS AND METHODS . 29 2.1 Podocyte cell culture . 30 Conditionally immortalized cell lines . 30 Primary podocyte cultures . 31 2.2 Adenoviral constructs and infection of cultured podocytes . 32 EP4 receptor adenovirus . 32 AT1 receptor adenovirus . 34 2.3 cAMP assay . 35
Mechanisms of Maternal Immune Tolerance During Pregnancy

Throughout their evolution, animals have developed mechanisms which protect them against parasites or infections by detecting and destroying foreign biological material within their own bodies. These mechanisms for excluding “non-self” biological materials whilst at the same time maintaining the integrity of the “self” have evolved for hundreds of millions of years into a highly complex body system, the immune system (Bainbridge, 2000). Any disbalance or alteration of the mechanisms maintaining the dynamic equilibrium between the “self” and “non-self” recognition could translate into a pathological state (or condition) like autoimmune disease at one end of the scale or immunodeficiency at the other.