Miracle-dz/UniFAR-FTUs huggingface dataset:
Test of RAM-based FPGA: methodology and application to the interconnect

This paper proposes a methodology for testing RAM-based FPGA taking into account the configurability of such flexible devices. Two different approaches with different objectives are identified: the Manufacturing Test Procedure and the User Test Procedure. The proposed method is used to generate a Manufacturing Test Procedure targeting the Interconnect Structure of RAM-based FPGA. It is demonstrated that a set of only 3 Test Configurations called the Orthogonal, the Diagonal-1 and Diagonal-2 Test Configurations suffice to make 100% of the considered realistic fault set non-redundant. Then the test of each configuration is shown equivalent to the test of classical buses. The final proposed Manufacturing Test Procedure present a constant number of Test Configurations (3) and very short Test Sequences.
Short chain and polyunsaturated fatty acids in host gut health and foodborne bacterial pathogen inhibition

ABSTRACT As a major source of microbes and their numerous beneficial effects, the gut microflora/microbiome is intimately linked to human health and disease. The exclusion of enteric pathogens by these commensal microbes partially depends upon the production of bioactive compounds such as short-chain fatty acids (SCFAs) and polyunsaturated fatty acids (PUFAs). These key intestinal microbial byproducts are crucial to the maintenance of a healthy gut microbial community. Moreover, SCFAs and PUFAs play multiple critical roles in host defense and immunity, including anti-cancer, anti-inflammation, and anti-oxidant activities, as well as out-competition of enteric bacterial pathogens. In this review article, we hereby aim to highlight the importance of SCFAs and PUFAs and the microbes involved in production of these beneficial intestinal components, and their biological functions, specifically as to their immunomodulation and interactions with enteric bacterial pathogens. Finally, we also advance potential applications of these fatty acids with regards to food safety and human gut health.
Maraviroc, a CCR5 Coreceptor Antagonist That Blocks Entry of Human Immunodeficiency Virus Type 1

Inhibition of the human immunodeficiency virus type 1 (HIV‐1) coreceptor is an encouraging new approach to pharmacotherapy against HIV. The HIV‐1 strain makes use of either the CCR5 or the CXCR4 coreceptor to gain access into host CD4+ cells. Maraviroc, the first HIV‐1 CCR5 coreceptor antagonist, blocks entry of HIV‐1. This recently approved drug has demonstrated clinically significant decreases in plasma concentrations of HIV‐1 RNA and increases in CD4+ cell counts; however, it is indicated only for use as salvage therapy. Drug resistance is a concern, as is selective pressure on viral coreceptor use, because viral coreceptor targets may switch as disease progresses. In addition, before maraviroc therapy can be started, costly assays are required to determine the host's viral coreceptor tropism. Emerging therapies targeting CXCR4, the other HIV coreceptor, have shown promise in decreasing plasma concentrations of HIV‐1 RNA. Long‐term studies with both targets are required to explore the critical issues of efficacy and immunologic safety, as the function of these coreceptors is linked to host chemokine pathways.
[The results of intramedullary nailing in children who developed redisplacement during cast treatment of both-bone forearm fractures].

OBJECTIVES We assessed the results of intramedullary nailing in children who developed redisplacement during cast treatment of both-bone forearm fractures. METHODS Twenty-eight children (19 boys, 9 girls; mean age 10.6 years; range 8 to 15 years) were treated with intramedullary fixation upon failure of initial reduction of both-bone forearm fractures after a mean of four weeks (range 3 to 6 weeks) of cast treatment. Intramedullary fixation was performed following closed (n=20) or open (n=8) reduction using K-wires in the first 10 cases, and titanium elastic nails in 18 cases. Single bone fixation was possible in four (14.3%) cases. For malunion assessment, the amount and location of the maximum radial bow were measured and compared with the normal side and with corresponding extremities of age-matched controls. Functional results were assessed using the Grace-Eversmann criteria. The mean follow-up was 14 months (range 12 to 18 months). RESULTS Except for a nonunion of the ulna in one patient who underwent single bone fixation, all correction losses could be restored to normal alignment and united within a mean of seven weeks (range 6 to 8 weeks). The amount and location of the maximum radial bow did not differ significantly from those of the normal side and control extremities (p>0.05). Functional results were excellent in 25 patients (89.3%), good in two patients (7.1%), and unacceptable in one patient (3.6%). None of the patients developed infection, neurapraxia, or after removal of the nail, angulation, refracture, or extremity length discrepancy. CONCLUSION Intramedullary fixation for correction losses during cast treatment of both-bone forearm fractures is a safe and inexpensive treatment, allowing early mobilization and providing excellent anatomic and functional results.
of the Radboud University Nijmegen

Background: To date there is no cure or an effective disease-modifying drug to treat dementia. Available acetylcholine-esterase inhibiting drugs or memantine only produce small benefits on cognitive and behavioural functioning and their clinical relevance remains controversial. Combined cognitive-aerobic interventions are an appealing alternative or add-on to current pharmacological treatments. The primary aim of this study is to investigate the efficacy of a combined cognitive-aerobic training and a single aerobic training compared to an active control group in older adults with mild dementia. We expect to find a beneficial effect on executive functioning in both training regimes, compared to the control intervention, with the largest effect in the combined cognitive-aerobic group. Secondary, intervention effects on cognitive functioning in other domains, physical functioning, physical activity levels, activities of daily living, frailty and quality of life are studied. Methods: The design is a single-blind, randomized controlled trial (RCT) with three groups: a combined cognitiveaerobic bicycle training (interactive cycling), a single aerobic bicycle training and a control intervention, which consists of stretching and toning exercises. Older adults with mild dementia follow a 12-week training program consisting of three training sessions of 30–40 min per week. The primary study outcome is objective executive functioning measured with a neuropsychological assessment. Secondary measures are objective cognitive functioning in other domains, physical functioning, physical activity levels, activities of daily living, frailty, mood and quality of life. The three groups are compared at baseline, after 6 and 12 weeks of training, and at 24-week follow-up. Discussion: This study will provide novel information on the effects of an interactive cycling training on executive function in older adults with mild dementia. Furthermore, since this study has both a combined cognitive-aerobic training and a single aerobic training group the effectiveness of the different components of the intervention can be identified. The results of this study may be used for physical and mental activity recommendations in older adults with dementia. Trial registration: The Netherlands National Trial Register NTR5581. Registered 14 February 2016.
Genetic structure of yellowback sea bream Dentex tumifrons in China inferred from AFLP data

The resource of yellowback sea bream Dentex tumifrons has declined very quickly in China due to overfishing since the 1970s. In this study, a total of 122 wild samples of the yellowback sea bream from marine waters of Qingdao (QD), Zhoushan (ZS), Shenzhen (SZ), and Beihai (BH) were analyzed using amplified fragment length polymorphism (AFLP). A total of 265 putative loci were detected by five AFLP primer sets, 116 of which were polymorphic (43.8%). The locality with the highest proportion of polymorphic loci (PPL, 29.4%) and number of polymorphic loci (PL, 78) was ZS, whereas that with the lowest was BH, in which a PL of 64 and a PPL of 24.2% were detected. The locality with the highest Nei’s gene diversity was also ZS with a value of 0.2237, whereas the locality with the lowest was BH with a value of 0.1905. Analysis of Wright’s Fst indicated that there existed distinct genetic differentiation among four localities (P≤0.001). It is speculated that there exist at least four distinct geographic subpopulations of the sea bream in Chinese waters. This research provides some of the first published AFLP data in the species.
Chaos Game Model of Knowledge Learning in Large-Scale Project Teams

This paper analyzes characteristics of chaos and game in large-scale project teams, utilizes a trait that participants lean to seek collective rationality and establish a partnership with a certain incentive and constraint from the perspective of the project manager, structures a chaos game model of internal knowledge learning in large-scale project teams and gives some constructive comments to control the chaotic parameters. It provides project managers for some references about the knowledge management.
Twitter Data Mining for the Social Awareness of Emerging Technologies

With the rapid development of Internet and information technology, social media has been growing fast. A large amount of social awareness data which represent the public's sensing and response to emerging technologies contained in social media, such as Twitter. By analyzing and mining the social awareness data to early detect the future trend of emerging technologies and identify the commercial potential of emerging technologies are crucial for government research and development strategic planning, social investment and enterprises practices. For this reason, this paper proposes a method to analyze the social awareness of emerging technologies based on Twitter data mining. Firstly, the natural language processing module in Thomson Data Analyzer is applied to extract the keywords from the tweets. Secondly, the social awareness information is analyzed by applying text mining and social network analysis, then, the social awareness of emerging technologies is mined by using time-slicing-based awareness information map. Finally, the perovskite solar cells technology is as a case study to analyze the effectiveness and feasibility of the method.
Idelalisib for the treatment of non-Hodgkin lymphoma

ABSTRACT Introduction B-cell Non-Hodgkin lymphomas (B-NHLs) include a number of disease subtypes, each defined by the tempo of disease progression and the identity of the cancerous cell. Idelalisib is a potent, selective inhibitor of the delta isoform of phosphatidylinositol-3-kinase (PI3K), a lipid kinase whose over-activity in B-NHL drives disease progression. Idelalisib has demonstrated activity in indolent B-NHL (iB-NHL) and is approved for use as monotherapy in patients with follicular lymphoma and small lymphocytic lymphoma and in combination with rituximab in patients with chronic lymphocytic leukemia. Areas Covered Herein we review the development and pharmacology of idelalisib, its safety and efficacy in clinical studies of iB-NHL, and its potential for inclusion in future applications in iB-NHL and in combination with other therapies. Expert Opinion Idelalisib adds to the growing arsenal of iB-NHL pharmacotherapeutics and to the progression of the field toward precision agents with good efficacy and reduced toxicities. Nevertheless, idelalisib carries important risks that require careful patient counseling and monitoring. The appropriate sequencing of idelalisib with other proven treatment options in addition to its potential for combination with established or novel drugs will be borne out in ongoing and planned investigations.
Septate junctions mediate the barrier to paracellular permeability in sea urchin embryos

In sea urchin embryos, blastula formation occurs between the seventh and tenth cleavage and is associated with changes in the permeability properties of the epithelium although the structures responsible for mediating these changes are not known. Tight junctions regulate the barrier to paracellular permeability in chordate epithelia; however, the sea urchin blastula epithelium lacks tight junctions and instead possesses septate junctions. Septate junctions are unique to non-chordate invertebrate cell layers and have a characteristic ladder-like appearance whereby adjacent cells are connected by septa. To determine the function of septate junctions in sea urchin embryos, the permeability characteristics of the embryonic sea urchin epithelia were assessed. First, the developmental stage at which a barrier to paracellular permeability arises was examined and found to be in place after the eighth cleavage division. The mature blastula epithelium is impermeable to macromolecules; however, brief depletion of divalent cations renders the epithelium permeable. The ability of the blastula epithelium to recover from depletion of divalent cations and re-establish a barrier to paracellular permeability using fluorescently labelled lectins was also examined. Finally, septate junction structure was examined in embryos in which the permeability status of the epithelium was known. The results provide evidence that septate junctions mediate the barrier to paracellular permeability in sea urchin embryos.
Validation of a newly adapted Chinese version of the Newest Vital Sign instrument

Objective To develop a Chinese version of the Newest Vital Sign (NVS-CHN) instrument and evaluate its psychometric properties. Methods To deal with cross-cultural adaptation problems, after translation of the NVS into Chinese, the Delphi method was used for experts and cognitive testing was used for participants. A cross-sectional study including 351 participants was conducted to assess the validity of the NVS-CHN. Internal reliability, criterion validity, and known-groups validity were investigated. The NVS-CHN was further validated against a suitable standard, the Chinese Citizen Health Literacy Questionnaire (CCHLQ). Results The validity of the NVS-CHN was established by conducting a Delphi survey (three rounds) and cognitive testing (three rounds). Cronbach’s alpha was 0.71, indicating that internal consistency was acceptable. A Spearman’s correlation coefficient of 0.68 between the NVS-CHN and CCHLQ revealed excellent criterion validity. Differences in NVS-CHN scores by education level confirmed known-groups validity. A receiver operating characteristics analysis showed that the area under the curve was 0.81, indicating that the NVS-CHN was an accurate health literacy assessment tool. A score ≥ 4 out of 6 best identified participants with adequate health literacy. Conclusions The NVS-CHN has excellent psychometrical reliability and validity, which make it a suitable tool to evaluate health literacy in China.
Andrology: Micromanipulation improves in-vitro fertilization results after epididymal or testicular sperm aspiration in patients with congenital absence of the vas deferens

In all, 58 couples suffering from infertility because of congenital bilateral absence of the vas deferens underwent a total of 67 combined microsurgical epididymal aspiration or testicular sperm extraction (TESE) and in-vitro fertilization (IVF) treatments. The oocytes recovered were inseminated by either the microdroplet IVF technique (n = 20), subzonal insemination (SUZI ; n = 10) or intracytoplasmic sperm injection (ICSI ; n = 37). Of the ICSI cycles, 12 were performed using spermatozoa obtained by TESE. Fertilization rates for epididymal spermatozoa were significantly higher for SUZI (17.9%, 17/95) and ICSI (34.4%, 137/398) than for microdroplet IVF (5.2%, 18/343) cycles. The proportion of cycles in which fertilization was achieved was higher in the SUZI (80%) and ICSI (95%) cycles than in the IVF cycles (45%). Delivery or an ongoing pregnancy was achieved in one (5%) IVF cycle, two (20%) SUZI cycles and seven (18.9%) ICSI cycles. SUZI or ICSI using epididymal or testicular spermatozoa significantly improved the oocyte fertility rate. The ICSI procedure was especially advantageous in patients for whom spermatozoa were obtained from a testicular biopsy.
Symmetry in a receptor mosaic demonstrated in the chick from the frequencies, spacing and arrangement of the types of retinal receptor

The mean percentages of receptors in the central retina were 14% rods, 32% double cones and 54% single cones. The mean percentages in the periphery were 33% rods, 30% double cones and 37% single cones. Single cones were classified into type I, type II and type III and the ratio of these types was about 5:2:1, respectively, in both central and peripheral retina. A statistical analysis showed that each type of receptor was evenly spaced in the receptor mosaic, but single cone type I tended to occur in pairs. The types of receptor were arranged in a pattern which was in the form of a hexagonal lattice. The pattern in the mosaic is regarded as the outcome of an evenly spaced distribution of the types of receptor. Perhaps pattern in the receptor mosaics of other vertebrate retinae should be interpreted as evenly spaced distributions of the types of receptor present. A method for detecting pattern in receptor mosaics, in which pattern is obscure, is described. A scheme accounting for the formation of the pattern in the chick retina during development is proposed.
Emerging technologies for the identification of therapeutic targets for the management of pre-eclampsia

Pre-eclampsia is a common and serious complication of pregnancy characterised by hypertension and proteinuria. Genetic and environmental factors influence the occurrence and progression of the disease. Emerging experimental systems and increasingly specific analytical methods for the study of differences between normal and pre-eclamptic placentae are close to identifying specific indicators of disease, which may allow early diagnosis and intervention and reveal targets against which therapeutic agents can be developed.
Symbolic meanings and e-learning in the workplace: The case of an intranet-based training tool

This article contributes to the debate on work-based e-learning, by unpacking the notion of ‘the learning context’ in a case where the mediating tool for training also supports everyday work. Users’ engagement with the information and communication technology tool is shown to reflect dynamic interactions among the individual, peer group, organizational and institutional levels. Also influential are professionals’ values and identity work, alongside their interpretations of espoused and emerging symbolic meanings. Discussion draws on pedagogically informed studies of e-learning and the wider organizational learning literature. More centrally, this article highlights the instrumentality of symbolic interactionism for e-learning research and explores some of the framework’s conceptual resources as applied to organizational analysis and e-learning design.
Unleashing Competition in EU Business Services

In most EU member states, the business services industry has booked no productivity growth during the last two decades. The industry’s performance in the other member states was weaker than that of its US counterparts. Exploring what may be causing this productivity stagnation, this policy brief reports that weak competition has contributed to the continuing malaise in European business services. The study analyzed the persistence (over time) of firm-level inefficiencies. The evidence further suggests that competition between small firms and large firms in business services is weak. Markets for business services work best in countries with flexible regulation on employment change and with low regulatory costs for firms that start-up or exit a business. Countries that are more open to foreign competition perform better in terms of competitive selection and productivity.The policy simulations in this paper show that greater import openness strengthens competition in business-services markets. The largest positive impact comes from lower regulatory barriers for growing and shrinking firms. More particularly, competitive selection would be fostered by a reduction of administrative and regulatory costs related to labour contracts, bankruptcy and start-up requirements.A key element of the European Commission’s Europe-2020 strategy is the single European market for services. Business services form one of the largest industries in Europe – and given its productivity stagnation, it deserves to be a priority target of the Europe-2020 strategy. Improving the way the business services market functions may have large positive knock-on effects for the EU economy.
Biochemical change exhibited by oral streptococci resulting from laboratory subculturing.

The intent of this study was to assess the effects of continued laboratory subculturing on selected biochemical properties of oral streptococci freshly isolated from dental plaque. Six fresh isolates (3 Streptococcus mutans and 3 non-mutans) and 2 laboratory strains were subcultured daily for a total of 225 transfers, and cells were harvested every 75 transfers from duplicate batch cultures grown with glucose at a constant pH. Eleven biochemical properties were assayed with cells, membranes and cell-free extracts and the results subjected to statistical analysis for differences between the duplicate cultures and the various subcultures. In addition, the activity of 19 hydrolytic enzymes was assayed with the semiquantitative apiZYM system (Analytab products). The activity of zero-time samples varied by as much as 241-fold for a single property with particularly low activity for EIIglc of the phosphoenolpyruvate phosphotransferase system and cell-associated extracellular polysaccharide synthesis. The 3 S. mutans fresh isolates had higher activity in 8 of the 11 assays compared with the 3 non-mutans strains, with extracellular polysaccharide synthesis the most significant trait. Statistical analysis of the 2816 assays of the 11 traits for the 8 test strains at the 4 selected time intervals revealed considerable change in the activity of the test parameters. The most notable changes in the S. mutans strains over the 225 subcultures were significant increases in glycolytic activity and decreases in hydrophobicity and extracellular polysaccharide synthesis activity. Of the measured properties, lactate dehydrogenase and cell-associated extracellular polysaccharide synthesis activity were the most stable and H+/ATPase activity was the most variable. (ABSTRACT TRUNCATED AT 250 WORDS)