Miracle-dz/UniFAR-FTUs huggingface dataset:
Rupture of a Breast Tissue Expander Due to Chest Wall Exostosis: Case Report and Literature Review

The incidence of device failure or rupture during tissue expansion is rare, and the etiology of device rupture is most commonly idiopathic; however, a multitude of potential etiologies have been reported including direct trauma, device over-expansion beyond manufacturer recommendations, capsular contracture, compressive forces during medical imaging studies, iatrogenic device damage during operative placement of the device or iatrogenic rupture during the process of filling the device. The authors report a case of device failure of the posterior wall of a tissue expander used for routine implant-based breast reconstruction that was attributed to bony exostosis of the anterior chest wall. They explore the relative incidence of bony exostosis-related and all-cause tissue expander rupture in peer-reviewed published literature. The present report illustrates the importance of evaluating the tissue quality of the periprosthetic capsule and pocket following a device failure to ensure that chest wall exostosis, a potential cause of further device failure, is not present.
Freelite for Measurement of Urine-Free Light Chains in Monoclonal Gammopathies

Introduction Monoclonal gammopathies represent a spectrum of clonal plasma cell disorders that form monoclonal gammopathy of undetermined significance (MGUS) through active multiple myeloma (MM) that are characterized by production of monoclonal immunoglobulin heavy and/or light chains. In these disorders, detection of free light chains (FLCs) has been an evolving and, at times, critical analysis for diagnosis, prognosis, and management of treatment. Historically, the standard for evaluating monoclonal light chain production has been the measurement of urine excretion of light chains determined by collecting a 24-hour urine specimen, measuring 24-hour urine total protein, and extrapolating the quantity of light chains using data from a urine protein electrophoresis (UPEP) and immunofixation electrophoresis (IFE). In 2001, Freelite was developing the utilization of immunonephelometric technology that allowed for improved detection of serum FLCs. Sensitivity of UPEP is 500 to 2000 mg/L, IFE is 150 to 500 mg/L, and Freelite is 1.5 to 3.0 mg/L. It was then demonstrated that serum Freelite alone detected more plasma cell disorders than older methods, with the higher detection rate likely due to the increased sensitivity and ability to measure the ratio of abnormal to normal light chains. Serum FLCs utilizing Freelite is now integrated into the standard of care in diagnosis and monitoring of plasma cell disorders. However, this should not replace obtaining urine IFE, as a small number of cases were missed when FLCs were not also measured. It has been our practice to use Freelite to measure the quantity of FLCs in single urine samples instead of obtaining a 24-hour urine sample with total protein and IFE. However, this has not been recommended for routine screening due to paucity of data using this assay for urinary measurements, and due to the concern for possibly confounding variable excretion of FLCs because of changes in renal function and variable renal reabsorption and degradation of light chains. The goal of this study was to evaluate the utility of using Freelite for measurement of spot urine FLCs.
A Recommendation Mechanism for Under-Emphasized Tourist Spots Using Topic Modeling and Sentiment Analysis

With rapid advancements in internet applications, the growth rate of recommendation systems for tourists has skyrocketed. This has generated an enormous amount of travel-based data in the form of reviews, blogs, and ratings. However, most recommendation systems only recommend the top-rated places. Along with the top-ranked places, we aim to discover places that are often ignored by tourists owing to lack of promotion or effective advertising, referred to as under-emphasized locations. In this study, we use all relevant data, such as travel blogs, ratings, and reviews, in order to obtain optimal recommendations. We also aim to discover the latent factors that need to be addressed, such as food, cleanliness, and opening hours, and recommend a tourist place based on user history data. In this study, we propose a cross mapping table approach based on the location’s popularity, ratings, latent topics, and sentiments. An objective function for recommendation optimization is formulated based on these mappings. The baseline algorithms are latent Dirichlet allocation (LDA) and support vector machine (SVM). Our results show that the combined features of LDA, SVM, ratings, and cross mappings are conducive to enhanced performance. The main motivation of this study was to help tourist industries to direct more attention towards designing effective promotional activities for under-emphasized locations.
Observer-Based Adaptive Hybrid Fuzzy Resilient Control for Fractional-Order Nonlinear Systems With Time-Varying Delays and Actuator Failures

This article investigates the adaptive output feedback resilient control problem for a class of incommensurate fractional-order (FO) nonlinear systems in the presence of time-varying delays and actuator faults by combining with an adaptive backstepping technique and a modified FO dynamic surface control (FODSC) method. Considering that the information of system states is not fully available, a hybrid fuzzy observer is designed to estimate the unmeasurable system states, where the neuro-fuzzy network system is introduced to handle the unknown nonlinear functions existing in the system. Furthermore, in order to overcome the problem of the explosion of complexity caused by traditional backstepping design procedure, an FO filter is constructed to pass the virtual control signal based on the FODSC scheme. Moreover, according to an indirect Lyapunov stability method, an adaptive hybrid fuzzy output feedback controller is designed to guarantee that all the signals of the closed-loop systems are bounded. Finally, three examples are given to verify the validity and superiority of the presented control scheme.
Building an inflammatory bowel disease network, a systems pharmacology approach

Objectives: Systems pharmacology it is a new tool that allows the study of complex biological systems [1], like immunological response to antigens. Inflammatory Bowel Disease (IBD) is a complex disorder, which evolves through several complicated immunological pathways and is characterized by processes of remission and relapse producing a functional impairment of the gut wall. It includes Crohn Disease (CD) and Ulcerative Colitis (UC) [2]. The objective of the current work was to develop a systems pharmacology model for CD and UC integrating the main known components and reactions as a tool to identify possible therapeutic targets and biomarkers.
Validación de la escala FEDPALLA-II para valoración y pronóstico de la piel perilesional en úlceras y heridas:

Objetivo: Validar la escala FEDPALLA-II y evaluar su aplicabilidad en la valoracion y pronostico de la piel perilesional en ulceras y heridas. Metodologia: Estudio observacional descriptivo y psicometrico de validacion de escalas. Modificacion y adaptacion de los items de la escala FEDPALLA para desarrollar una nueva version denominada “FEDPALLA -II”. Evaluacion intra- observador de la aplicabilidad en una muestra predeterminada de 118 pacientes con ulceras y heridas. Resultados: La Escala Fedpalla II, en comparacion con la anterior version, presenta un cambio de denominacion en uno de sus items (se cambia “dermatitis” por “eccematizacion”) y se mejoro la valoracion de 4 parametros que hacen referencia a la hidratacion, vascularizacion, bordes y depositos en la piel. La consistencia interna obtenida fue de 0,78 con una varianza explicada del 75%. Su aplicabilidad se evaluo en 236 ulceras por presion y piel circundante, obteniendo valores y puntuaciones mas descriptivos. Conclusiones: Los resultados psicometricos y evaluacion de la aplicabilidad de la Escala Fedpalla-II permite, en comparacion con la anterior, obtener una mayor fiabilidad y validez a la hora de su uso en la practica clinica, en referencia al pronostico y valoracion de la piel perilesional de ulceras y heridas. Palabras clave: Ulcera por presion, Piel perilesional, Validacion escalas, Cuidados de la piel. ABSTRACT: Objective: Validate the FEDPALLA-II scale and evaluate its applicability in the assessment and prognosis of perilesional skin in ulcers and wounds. Methodology: Psychometric study of validation of scales. Modification and adaptation of items on the Fedpalla scale to develop a new version called “Fedpalla-II”. Observational evaluation of applicability in a predetermined sample of 118 patients with ulcers and wounds. Results: The Fedpalla II Scale, in comparison with the previous version, presents a change of denomination in one of its items (“dermatitis” is changed to “schematization”) and the assessment of 4 parameters that refer to the hydration, vasculature, edges and deposits on the skin. The internal consistency obtained was 0.78 with an explained variance of 75%. Its applicability was evaluated in 236 pressure ulcers and surrounding skin, obtaining more descriptive values ​​and scores. Conclusions: The psychometric results and evaluation of the applicability of the Fedpalla-II Scale allows, in comparison with the previous one, to obtain greater reliability and validity at the time of its use in clinical practice, in reference to the prognosis and assessment of the skin perilesional ulcers and wounds. Keywords: Pressure ulcer, Perilesional skin, Validation scales, Skin care.
PATIENT ADHERENCE TO A CANCER THERAPY REGIMEN: ITS BEHAVIORAL ASPECTS AND VARIABLES RELATED TO ADHERENCE

William O’Brien, Advisor The purpose of the study was to assess patient appointment keeping and adherence to behavioral aspects of cancer radiation treatment. In addition, the study evaluated the relationship between an information seeking coping style (monitoring), anxiety, depression, optimism, and adherence. A questionnaire was developed to assess adherence to recommendations regarding weight maintenance, fluid intake, skin care, reporting side effects, and reading informational materials. Cancer patients completed the Mental Adjustment to Cancer Scale (MAC), Affects Balance Scale (ABS), Life Orientation Test (LOT), and the Monitor-Blunter Scale (MBSS) at the beginning of treatment and the adherence questionnaire at Week 2 and 6. Hierarchical regressions evaluated if monitoring, depression, optimism, and anxiety predicted adherence at Week 2, Week 6, and missed appointments. As hypothesized, monitoring and depression from the ABS were correlated with missed appointments. However, MAC depression scores were in the opposite direction to that hypothesized. Optimism and anxiety were not associated with adherence.
Genetic polymorphisms to predict progression-free survival in patients with metastatic castration-resistant prostate cancer (mCRPC) receiving abiraterone therapy: Results from the NCI 9012 trial.

145Background: Abiraterone is a CYP17 inhibitor approved for treatment of men with mCRPC. The NCI 9012 trial evaluated abiraterone alone with or without the PARP inhibitor veliparib in mCRPC patients. We hypothesized that germline genetic variation in the androgen axis and other metabolic enzymes would predict response to veliparib + abiraterone vs. abiraterone alone. Methods: A randomized trial cohort of (148) men with advanced mCRPC treated with abiraterone with or without veliparib was genotyped for 120 DNA polymorphisms in genes involved in androgen metabolism using Lifetech Open array chips. Blood for pharmacogenomic SNP analysis were collected at pre-treatment from each subject into 10-mL EDTA tube. Polymorphisms were tested using Cox models without treatment for prognostic testing and with treatment arm for predictive testing. Results: Genotyping was completed in 143 of 148 men; all were treated with abiraterone; 72 without veliparib (Median PFS: 10.3m) and 71 with veliparib (Median PFS: 11.3m). Po.
Mobile App Service Quality Dimensions and Requirements for Mobile Shopping Companion Apps

The increasing utilization of mobile apps for shopping leads retailers to provide customers with dedicated mobile shopping companion apps to create an omni-channel shopping experience involving traditional brick-and-mortar, electronic and mobile business. Mobile shopping companion apps extend the traditional and electronic services of brick-and-mortar retailers by an additional mobile channel providing the customer with a digital companion supporting the shopping within and outside the stores using mobile technology. A twofold approach is pursued in this thesis. Firstly, a structured literature review is conducted to identify candidate dimensions for developing a scale for measuring the service quality of mobile shopping companion apps. Secondly, design requirements for improving the service quality of these mobile apps are deduced from online customer reviews of three exemplary mobile shopping companion apps applying a qualitative content analysis. The mobile app service quality of mobile shopping companion apps can be measured using a hierarchical and multi-dimensional scale consisting of three primary dimensions, seven secondary dimensions and 22 related items. The primary dimensions interaction quality, environment quality and outcome quality structure the secondary dimensions responsiveness, information, security and privacy, design, performance, technical reliability and valence. Based on these dimensions, 22 implementation guidelines and 14 service design requirements are derived as potential areas for optimizing the mobile app service quality of mobile shopping companion apps and achieving a high overall service quality. A mobile shopping companion app should include a set of features consisting of 16 features from three different areas. Results show that measuring the service quality of mobile shopping companion apps require for a tailored measurement scale. Equally, design requirements are proposed for this particular category of mobile apps. Retailers should provide a single mobile shopping companion app providing all features and mobile services to the customer.
World of Warcraft Stats System: Evolution and Casualization

Since World of Warcraft release, it has remained as the MMORPG with more subscribers of the market, and during that time, it has evolved in diverse ways. One of the aspects that have suffered more changes is its character stats system, which is an elemental part of this game. By studying it, we can learn much about the game evolution. Some players feel that the game has evolved to appeal to more casual audiences. In this study, we will analyze the development of World of Warcraft character stats system through the expansions while trying to determine if these changes have promoted the casualization of the game. Study results could be inter-esting for game designers and game researchers as an example of the long-term evolution of one of the most important computer games in history.
A STUDY OF URINARY TRACT INFECTIONS DUE TO MULTIDRUG RESISTANT BACTERIA IN CRITICAL CARE UNIT OF A MEDICAL COLLEGE AND HOSPITAL

The present study was designed to determine antibiotic resistance pattern against commonly used drugs for urinary tract infections in patients of the ICU of the KPC Medical College and Hospital from November 2011 to May 2015. Commonly isolated organisms were, Klebsiella pneumoniae (39.02%), Escherichia coli (8.10%), Pseudomonas aeruginosa (17.07%), A cinetobacterbaumannii (30.08%) and Enterobacter aerogenes (5.60%). Susceptibility testing was determined using the Microscan, (Siemens) and MICs of different antibiotics were determined. Since surveys of antimicrobial resistance form the basis for decisions on empirical therapy this study was designed to provide a guideline for initiation of antibiotic therapy immediately after identification of organism (even before sensitivity report is obtained).
Trans-acting role of the leader peptide peTrpL in posttranscriptional regulation of multiresistance

Bacterial ribosome-dependent attenuators are widespread posttranscriptional regulators. They harbour small upstream ORFs (uORFs) encoding leader peptides, for which no functions in trans are known yet. In the soil-dwelling plant symbiont Sinorhizobium meliloti, the tryptophan biosynthesis gene trpE(G) is preceded by the uORF trpL and is regulated by transcription attenuation according to tryptophan availability. However, trpLE(G) transcription is initiated independently of the tryptophan level in the cell, thereby ensuring a largely tryptophan-independent production of the leader peptide peTrpL. We provide evidence that peTrpL plays a role in the differential posttranscriptional regulation of the smeABR operon encoding the major multidrug efflux pump SmeAB and the TtgR-type transcription repressor SmeR. We show that peTrpL is involved in a tetracycline-dependent smeR mRNA destabilization and forms an antibiotic-dependent ribonucleoprotein (ARNP) complex with smeR and its antisense RNA (asRNA). Induction of asRNA transcription, ARNP formation and smeR downregulation were promoted by several antibiotics and the flavonoid genistein, and the resistance to these antimicrobial compounds was increased by peTrpL. The role of peTrpL in resistance is conserved in other soil Alphaproteobacteria.
Utilization and cultivation opportunities of pelawan (Tristaniopsis merguensis Griff.) as a biomas energy source in Southern Sumatera

Pelawan (Tristaniopsis merguensis Griff.) has been used for many purposes in Southern Sumatera including for energy, food and medicine but effort to cultivate the species is not yet tried properly. The wide utilization resulting overexploitation and degraded its natural habitats. Research on pelawan utilization and cultivation was conducted with survey and field experimental method. Survey conducted on its natural habitats and related home industry and the field experimental is conducted on the Forest Area for Specific Purpose (KHDTK) of Kemampo to promote cultivation of the species. Result showed that pelawan was mostly used for energy purpose in the form of small timber both used directly as firewood or after being converted into charcoal. Utilization of pelawan as firewood is mostly done by household and several restaurants to get food with distinctive taste but pelawan charcoal is managed as an export commodity product by home industry. Pelawan has strong ability to sprout and stump sprouting became the main regeneration mechanism, however, generative reproduction is an important mechanism to increase its stand productivity. Cultivation trials showed that pelawan can be cultivated in generative reproduction with diameter growth of 4.5 cm and height of 457 cm in the age of 3 years old.
A NOVEL DUAL-FREQUENCY OMNIDIRECTIONAL ANTENNA WITH TRANSMISSION LINE RESONATORS LOADING

A novel dual-frequency antenna with horizontally polarized (HP) omnidirectional radiation is presented in this paper. The antenna consists of four printed arched dipoles, four planar baluns, and a four-way power splitter. The balun as well as the power splitter works as the feed network. By loading a transmission line resonator (TLR) as the near-field coupling parasitic element, the dual-frequency characteristics can be realized. After the design principle is stated, a sample antenna is manufactured and measured to prove the predicted performance of the proposed antenna. The measured results agree well with the predicted ones.
Pulmonary infections in children – Multimodality evaluation

Poster: "ESTI 2015 / P-0113 / Pulmonary infections in children – Multimodality evaluation" by: "A. S. Teixeira Gomes, M. S. R. O. Faustino, L. Lobo, I. Tavora; Lisbon/PT"
Could ASEAN be an economic and political counterbalance to rising china in the region?

National security is one of the most critical elements for the society, economy and the political system of a given country. Especially, it is unconditionally important for the stability, sustainability and prosperity of national development. Moreover, it is also unconditio¬nally the top priority for all ASEAN countries that have to cope with the continually rising China in all aspects of development of the Asia-Pacific region. The present article is using case study analysis and comparative empirical analysis as a research methodology to investigate and find out the right answer to the question exposed in its title. The article approaches and treats security and military science as interdisciplinary area of contemporary research. At the same time they are considered as one of the branches of social science. In the beginning of 21st century, the economic relations as well as the geo-political relations between China and ASEAN have made many progresses and positive changes towards right direction, in line with common principles of peaceful and secured development in the region. However, this current relationship still shows many difficulties and obstacles that the two sides need to solve and overcome in order to benefit from the existing potentials of each other. The first aim of this present article is to focus on overall complex relationship between ASEAN and China that could pose real threat and danger to the ASEAN nations in terms of its inability to counterbalance the rising China in the Asia Pacific region. The second aim of the article is to propose some useful recommendations and viable solutions to guard the safety of the people, security in the society and economy, the political existence of the ASEAN bloc.
A Taxonomy of Metrics for Cryptographic Systems

—Measuring the security of cryptographic systems (algorithms, protocols, software and hardware implementations etc.) is a difﬁcult task. There does not exist one simple and easy to measure value that could be used to evaluate the relative strength of different cryptographic systems. On the other hand, there are more and more use cases where protections granted by cryptographic systems are needed. In some cases, there are certiﬁcation and classiﬁcation requirements for the use of cryptosystems that would beneﬁt from good measures. Also new standards are being created for cryptography, usually based on competitions, where the proposals are evaluated based on some criteria. In this paper, we describe a taxonomy of the multiple metrics that can be associated with cryptographic systems and evaluate them based on a number of different attributes. We also reﬂect our taxonomy to the decisions made in several cryptographic standardisation competitions.