Miracle-dz/UniFAR-FTUs huggingface dataset:
The Application of Lactate Dehydrogenase in Coronavirus Disease 2019 as the Best Indicator for the Progression and Clinical Status: A Case-Control Study

Introduction Coronavirus disease 2019 (COVID-19) is now officially a pandemic. Current studies observed extensive abnormal indexes in COVID-19 patients and significant differences between mild and severe patients. However, which index would perform better as the indicator of disease progression merits further investigation.Methods We enrolled COVID-19 patients who were admitted to Shanghai Public Health Clinical center. We closely monitored the following candidate indictors: white blood cell, lymphocyte, platelet, CD4 T cell, CD8 T cell, alanine aminotransferase, estimated glomerular filtration rate (eGFR), fibrin degradation products (FDP), D-dimer, creatine kinase, myoglobin, troponin T (TnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), lactase dehydrogenase (LDH), C-reactive protein (CRP), and procalcitonin. The correlation with illness severity were assessed by Spearman analysis and the ability of differentiating the clinical statuses was quantified as the AUC value of the ROC curve. Results A total of 326 patients were enrolled, including 299 mild-ordinary and 27 severe-critical patients. At admission, D-dimer and CRP were elevated above normal range both in mild-ordinary and severe-critical patients. LDH, NT-proBNP, myoglobin, CD4 T cell, eGFR, FDP and PCT were beyond normal range in the mild-ordinary stages of severe-critical patients, but remained normal in the persistently mild-ordinary patients. Top 5 parameters with highest spearmen coefficient were LDH, procalcitonin, NT-proBNP, myoglobin and D-dimer (Spearman coefficient: 0.488, 0.453, 0.414, 0.412, 0.407). Comparing between mild-ordinary stage and severe/critical stage, LDH showed the highest receiver operating characteristics (ROC) area under the curve (AUC) of 0.951. PCT ranked second, with the ROC AUC of 0.905. Comparing between mild-ordinary and severe stages, only LDH had the ROC AUC of over 0.90 (0.927). Conclusions This study found LDH to be a superior indicator for COVID-19 status and had the potential to optimize the clinical management strategy.
Additive Approach to Simulation of Malignant Neoplasms Using the Monte Carlo Method

The paper is devoted to additive simulation of Raman light scattering by skin cancer using the Monte Carlo method. Raman light scattering from normal skin, malignant melanoma and basal cell carcinoma is investigated. Based on the photon transport algorithm proposed by L. Wang and S. L. Jacques, a two-stage algorithm for simulating Raman light scattering from skin has been developed. A method for additive modeling of skin pathologies is proposed. The main idea of this method is a hypothesis that an experimental Raman spectrum of normal skin, obtained by averaging in vivo Raman spectra of normal skin, may be served as a “substrate” for the feature simulated Raman spectrum. Thus, the pathology, for their part, may be “grown” by adding on this “substrate” Raman specific components set related to a tumor type. Additive simulation of malignant melanoma on various stages and basal cell carcinoma has been carried out. The possibility of using the developed algorithm to determine the component composition of the skin by the in vivo Raman spectrum of skin is discussed. An attempt to evaluate the change in the concentration of skin components during the development of cancer has been made.
Immunogene und nicht- immunogene Hyperthyreose – Ein Vergleich

Zusammenfassung In einer retrospektiven Studie wurden 161 unbehandelte hyperthyreote Patienten in 74 mit immunogener Hyperthyreose (IMH) und 87 mit nicht- immunogener Hyperthyreose (NIMH) unterteilt. Die Frequenz der Beschwerden und die mittleren Hormonkonzentrationen lagen bei IMH signifikant höher als bei NIMH. Das mediane Schilddrüsenvolumen war bei IMH signifikant kleiner. Eine diffuse Echoarmut wurde nur bei 50% der Patienten mit IMH beobachtet und bei 5% bei solchen mit NIMH. Eine homogene Aktivitätsverteilung von 99mTc in der Schilddrüse fand sich bei 95% der Patienten mit IMH und nur bei 3% der NIMH. Obwohl der Median der globalen thyreoidalen Tc- Aufnahme bei der IMH signifikant höher lag, ergab sich eine breite Überlappung der Werte der beiden Gruppen. Die Hormonproduktion ist bei der IMH höher als bei der NIMH. Um beide Gruppen voneinander zu trennen, sind mehrere Kriterien anzuwenden. Sie zeigen ein unterschiedliches diagnostisches Gewicht.
Influence of Pseudomonas spp. on Okra (Abelomuscus esculantaus L.) growth parameters and antioxidant activities under soil salinity

In this study total twenty seven gram negative NaCl tolerant rhizobacterial strains were isolated from disturbed soils of Lucknow districts. The 3 selected sampling sites were Bijnor, Pasi Quila and Babasaheb Bhimrao Ambedkar University Campus, Lucknow, India. The isolates have been investigated for different plant growth promoting and biochemical activities. Based on morphological and biochemical tests the total eight (8) rhizobacterial strains were designated as Pseudomonas spp. Among PGP traits, all 8 Pseudomonas strains were examined for Indole-3-Acetic Acid (IAA) production activity. The bacterialisolate IAA4 produces maximum 21.16 ± 3.24 μg mL–1 of IAA at 100 μg mL−1 tryptophan concentration among Pseudomonas strains. This strain show excellent P solubilization and N fixatation in qualitative assay. The higher amount of NaCl salt in soils positively reduces paddy plant physiology and growth parameters. The IAA4 inoculation in okra seeds significantly (p < 0.001) improved plant growth parameters, green pigments and modulate antioxidant activities under pot experimental study.
Ameliorating Effect Of Emblica Officinalis On Lipid Profile Of Endosulfan Induced Mice

In the recent times wide use of agrochemicals in agricultural practice has caused severe health hazards to humans while their side effects have damaged the environment also. Endosulfan is an organochlorine insecticide effective against a wide range of pests of cereals, coffee, cotton, fruits, oilseeds, potato, tea and vegetables.
WEATHER FORECASTING USING REGRESSION

— Weather forecasting has traditionally been done by complex simulation models of physics made up of complex equations of fluid dynamics and thermodynamics. Due to this, even minute errors in the simulation causes huge differences in the results. Thus, this method is inaccurate for long-term forecasting. On the other hand, machine learning techniques are more robust to minute errors in training datasets. In this paper we explore machine learning regression algorithm application to weather forecasting, to potentially generate more accurate weather forecasts for large periods of time. The regression model, described in this paper, will be able to capture trends in the weather. This model is outperformed by professional weather forecasting services.
Effect of Catalyst Length and Hydrogen Addition on the Combustion Characteristics of n-Butane in a Catalytic Swiss-Roll Combustor

The effect of catalyst length and hydrogen addition on the combustion characteristics of n-butane in a catalytic Swiss-roll combustor was studied experimentally. The results show that the 4.5-mm ceramic with Pt catalyst slightly outperforms the 3.0- and 6.0-mm ceramics. However, changing only the catalyst length does not expand the lower flammable limits to lean fuel. Further experiments on the combustor with the 4.5-mm ceramic show that the addition of hydrogen to flammable mixtures can expand the lower flammable limits of such mixtures to lower than 0.5. Analyses on exhaust gas and stable combustion temperature indicate that hydrogen supplies heat through complete combustion and enhances the n-butane conversion ratio. A high amount of hydrogen is favorable for flammable range expansion. Moreover, a higher amount of hydrogen can further reduce the lower limits.
Comparison of Sexuality in Women with Vulvovaginal Candidiasis Versus non Infected Women

Sexual health is an important part of the quality of life of women and is defined by the World Health Organization as “a state of physical, emotional, mental and social well-being related to sexuality. The aim of this study was to assess sexual function in women with vulvovaginal candidosis in comparison with women without lower genital tract dysfunction. The study was performed on 200 married women, who attended the outpatient clinics in Benha University Hospital during the period from January to May, 2020. Regarding the demographic data, 40% and 58% of infected and control groups respectively, belonged to the age group of 30-39 years old, 37% and 72% of the same groups had secondary school and university degree educational level. The majority of both groups were living in the rural areas. VVC was associated with lower sexual desire, decreased lubrication, less frequency of reaching orgasm and low satisfaction of sexual life.
Cerebrospinal Fluid Microglial Activation Markers in Patients With Neuromyelitis Optica

Aim: Microglia, the resident immune cells in the brain can activated by inflammation in the central nervous system (CNS), then become significant sources of inflammatory mediators. However, little is known about that whether microglia activation in neuromyelitis optica (NMO). The aims of this pilot study were to investigate the levels of the biomarkers of microglia activation, YKL-40, sCD163 and sCD14 in patients with NMO，and the possible associations between those and Expanded Disability Status Scale EDSS scores. ﻿Methods: We found significantly higher CSF YKL-40, sCD163 and sCD14 levels in NMO patients. The level of neurological disability was assessed by the EDSS scores.Results: The levels of microglia biomarkers in NMO patients were positively correlated with Expanded Disability Status Scale (EDSS) scores, but not in MS and GFAP groups. Finally, we showed levels of CSF YKL-40, sCD163 and sCD14 were higher in NMO patients and positive relationship with disease severity of NMO. Conclusion: These finding suggesting that microglial activation, may be implicated in the pathogenesis of NMO.
Effects of Intraoperative Ketamine Versus Dexmedetomidine on Release of Inflammatory Mediators in Laparoscopic Hysterectomy. Prospective Randomized Trial

Background: Surgery and anesthesia are sources of stress to the patients. Inflammatory reactions to this stress have adverse effects on wound healing and remote organs in addition to long-term sequels e.g. adhesion formation. We compared the effects of dexmedetomidine and ketamine on perioperative level of serum inflammatory biomarkers including tumor necrosis factor-α, interleukin-6, and C- reactive protein. Methods: We included Seventy-five patients, aged 30-60, ASA I–II, and scheduled for laparoscopic hysterectomy. Patients were randomized to receive intraoperative ketamine (bolus dose 0.25 mg/kg then continuous infusion 250 µg/kg/h), dexmedetomidine (1µg/kg bolus dose then continuous infusion 0.5 µg/kg/h), or placebo. The primary outcome was to measure serum level of inflammatory biomarkers. Hemodynamic parameters, Recovery time, and complications within 24 hours postoperative were recorded.Results: Whilst there was significant increase in concentrations of inflammatory biomarkers 6 and 24 h postoperative in all groups, there were significant differences between ketamine and dexmedetomidine group as compared to control group with no significant differences between ketamine and dexmedetomidine group. As regard hemodynamic parameters, there were significant increase in ketamine group and decrease in dexmedetomidine group as compared to base line with no need for medical intervention. There was delayed recovery in ketamine group versus control and dexmedetomidine group (24.3 ± 6.4, 12.6 ± 2.0, 13.5 ± 3.3 min respectively; P < 0.001). More complications were reported in ketamine group but did not reach statistical significance. Conclusion: Dexmedetomidine and ketamine are comparable as regards attenuation of perioperative inflammatory response. However, dexmedetomidine has a favorable safety profile.Trial registry number is (PACTR201910617459894: date of registration 10/24/2019)
Clinical characteristics of breast abscesses induced by methicillin-resistant Staphylococcus aureus during lactation

Background This study aims to identify the differences in patients with breast abscesses in combination with the infection of methicillin-resistant Staphylococcus aureus (MRSA) or with methicillin-susceptible Staphylococcus aureus (MSSA) during lactation in the clinical characteristics, efficacy of puncture, antibiotic use, treatment duration, breastfeeding after illness and recurrence. Methods Clinical data of patients with breast abscesses during lactation who were treated in our hospital from January 2014 to February 2017 were reviewed. According to bacterial culture results, they were divided into MRSA (n = 260) and MSSA (n = 962) groups. The hospitalisation, postpartum time, age, location of abscess cavities, number of abscess cavities, maximum amount of punctured pus, frequency of punctures, failure of puncture, antibiotic use, treatment duration, delactation and recurrence were compared between groups using a t-test and a chi-squared test. Results The statistical analysis showed that only delactation was statistically significantly different between the groups (P = 0.018). Hospitalisation, postpartum time, age, location of abscess cavities, number of abscess cavities, maximum amount of punctured pus, frequency of punctures, failure of puncture, antibiotic use, treatment duration and recurrence showed no statistically significant differences (P = 0.488, P = 0.328, P = 0.494, P = 0.218, P = 0.088, P = 0.102, P = 0.712, P = 0.336, P = 0.512, P = 0.386 and P = 0.359, respectively). Conclusion Patients with breast abscesses combined with MRSA infection during lactation presented no significant differences in the clinical manifestations, efficacy of puncture, antibiotic use or treatment duration from those with MSSA infection. However, the patients infected with MRSA were more susceptible to delactation after illness.
PHYTOCHEMICAL SCREENING AND ANTI-LISTERIAL ACTIVITY OF ESSENTIAL OIL AND CRUDE EXTRACTS FROM SOME MEDICINAL PLANTS GROWING WILD IN BECHAR (SOUTH WEST OF ALGERIA)

The antibacterial effect of essential oil and crude extracts extracted from six aromatic plants (Rosmarinus officinalis L, Matricaria pubescens (Desf.), Artemisia herba-alba Asoo, Rhetinolepis lonadioides COSS, Vitex agnus castus and Juniperus phoenicea) was investigated against Listeria monocytogenes. We wanted to proof an antibacterial activity of those plants with two most commonly used methods: disc diffusion method and broth dilution method. With the disc diffusion method we have obtained the inhibition zone. Minimal inhibitory concentration (MIC) corresponding at the lowest concentrations, where no visible bacterial growth was recorded, were assumed as values (MIC). Overall, extracts from Matricaria pubescens (Desf.) and Artemisia herba-alba Asoo showed the stronger anti-Listeria activity than the others plants. The diameters of growth inhibition zone ranged from 24 to 31mm (including the diameter of the disc-6 mm) with the highest inhibition zone values observed with ethanolic extract of M. pubescens (Desf.) (31mm). For essential oils obtained from hydrodistillation. The diameters of inhibition zone ranged from 13 to 18mm (including the diameter of the disc-6 mm) with the highest inhibition zone values (18mm) observed with Rhetinolepis lonadioides COSS, Vitex agnus castus and Artemisia herba-alba Asoo. We determined MIC values in the ranges from 0.5 to 2.5 mg/ml for extracts and essential oil in the medium. The MIC values of the ethanolic extract against Listeria monocytogenes was 0.5 mg/ml with M. pubescens (Desf.).
Spray drying of beet root juice using different carriers

The present work describes the process of spray drying of betalain dye from red beet roots using different carriers. The carriers used are malto dextrine, gum acacia and soluble starch. Effect of these carriers, in varying percentages, with freshly extracted beet root juice was studied during spray drying. The chamber temperature of spray drier was maintained in the range of 150°-165°C. These studies showed that with decrease in percentage of carriers in the juice, the percent yield of betalains increased. This was observed by optical density and betalain content estimation. The shelf life studies of this spray dried betalain dye powder, over 180 days showed that the dye is quite stable in the temperature range of - 4°C to 20°C.
Edukacja oparta na neurofaktach – wstępna analiza nowego protokołu badawczego opartego na metodologii pedagogiki i medycyny

Recent years have brought with them an increase in the interest of educators in research in the field of neuroscience. Among the publications – including scientific ones – there were various proposals that referred to brain research. Neuropedagogy, neuroeducation and neurodidactics have become an attractive field of interdisciplinary discussions. Unfortunately, a significant impact on their quality was the fact that evidence-based education is still a little-known approach among educators. This article presents the procedure based on brain imaging and pedagogical methodology. Preliminary results of the analysis have shown that the information obtained in this way can be the basis for individualizing the education of children with developmental disorders.
ANTIOXIDANT POTENTIAL OF METHANOL STEM EXTRACT OF Berberis aristata DC. AND BERBERINE- A BIOACTIVE COMPOUND ISOLATED FROM Berberis aristata DC.

Natural products contain important combinations of ingredients, which may to some extent help to modulate the effects produced by oxidation substrates in biological systems. Oxidative stress has been thought to contribute to the general decline in cellular functions that are associated with many human diseases including Alzheimer disease, amyotrophic lateral sclerosis, Parkinson’s disease, atherosclerosis, ischemia/reperfusion neuronal injuries, degenerative disease of the human temporomandibular-joint, cataract formation, macular degeneration, degenerative retinal damage, rheumatoid arthritis, multiple sclerosis, muscular dystry, Inflammatory Bowel Disease, cancers as well as the aging process itself. Increased cellular level of ROS due to oxidative stress can result in an increased steady state level of oxidative DNA damage. The objective of the study was to investigate the antioxidant activity of methanol extract from the stem of Berberis aristata DC. and berberine a bioactive isolated compound of Berberis aristata DC. by H2O2 and DPPH in-vitro methods. It was observed that the methanol extract of the stem of Berberis aristata DC. and berberine were effectively scavenged free radical activity. Those antioxidant activities were compared to standard antioxidant such as LAscorbic acid. Our findings provide evidence that the crude methanol extract of stem of Berberis aristata DC. and its bioactive isolated compound (Berberine) is a potential source of natural antioxidant and this justified its uses in folkloric medicines.
The Future of Mesenchymal Stromal Cells in cancer – A Bibliometric Analysis

BackgroundMesenchymal stromal/stem cells have garnered much interest in the field of cancer biology. Bibliometric analysis of a scientific field has the potential to reveal insights pertaining to the maturity of the field, the hotspot sources of publication and temporal shifts in research subcategories within the field. Despite the benefits of such an analysis, one has not been conducted to date.MethodsThe Web of Science™database and VOSviewer software were used to analyse publication and citation data for all publications relating to Mesenchymal Stromal/Stem Cells in oncology. Contributions to the literature were also identified by country, journal and cancer type. Keyword analysis identified trends in developing research categories.Results9927 published articles were analysed. The current publication rate fits an exponential trend(r2 = 0.97). The U.S. and the People’s Republic of China have the highest overall publications but when corrected for population and citations per article, the most successful countries are Singapore, Luxembourg and Switzerland. In the past 15 years 74% of articles have been in cancer specific journals. Breast cancer publications account for 42% of common cancer articles. Most articles were published in journals that had a basic science focus (44%). Keyword analysis resulted in 3 distinct clusters aligned with 1. Characterisation and nomenclature, 2.Clinical and 3.Molecular function. The most recent publications favour topics on Molecular function. ConclusionsResearch on Mesenchymal Stromal/Stem Cells in oncology is experiencing exponential growth. There is widespread acceptance of basic science research on MSCs in cancer specific journals and a niche for more translational and clinically focused studies.
Characterization of Wild North American Grapevine Cold Hardiness Using Differential Thermal Analysis

The cold hardiness of 33 different grapevine genotypes, representing six wild North American grapevine species, one wild Asian grapevine species, and six hybrid grapevines, was evaluated by measuring lethal temperatures for dormant buds using low temperature exotherms. Studies were conducted over three different winters to characterize the relative level of cold hardiness and responsiveness to changing weather patterns of each species. Major differences in the winter conditions demonstrated that wild grapevine has a great capacity for responding to both warm and cold temperature events during the dormant season. Results indicated that wild grapevine species with northern distributions tended to exhibit greater cold hardiness and responsiveness to temperature fluctuations than their southern-dwelling counterparts. Statistical modeling of low temperature exotherm results across the three winters indicated that each grapevine species had a distinct and innate capacity for responding to temperature. These results may be important for future grapevine breeding in areas with expected increases in winter temperature variation. Additionally, these results demonstrate the potential for genetic determinants of temperature responsiveness that may be investigated and mapped for future grapevine improvement.
Effect of Trishothadi Lepam on Tropical foot ulcer – Case Report

Siravyadhana and Trishothadi Lepam application was intended for healthy wound healing. Probably it will have an understanding of underlying mechanism of relieving vascular stasis, reducing venous congestion and beginning of re-vascularization and other wound healing process. The Group-B showing maximum percentage of benefit followed by Group-A. Hence it can be concluded that overall benefit is found maximum in Group-A where Siravyadhana with Trishothadi Lepam was administered. The drug Trishothadi Lepam might be shown the efficacy due to Lekhana, Kledahara, Shoshana, Shotha & Dahahara, RaktaShodhaka and Twaka Prasadana properties. this procedure is found to be very much safe, simple, cost-effective, easily administered in the patients of foot ulcers leading them for complete healing avoiding the most unwanted outcome of amputation.