Miracle-dz/UniFAR-FTUs huggingface dataset:
Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae

Proteins are continuously synthesized and degraded to meet the demands of the cell. Hence, a proper balance between synthesis, folding, disaggregation and degradation is of essence to ensure cell survival. Disruption of any part of this proteostasis network may have severe consequences for cellular fitness and longevity. This thesis focuses on how proteostasis decline and aggregate-management is linked to aging in the yeast Saccharomyces cerevisiae and why aggregates accumulate in the yeast mother cells. The study revealed that three complementary processes are involved in this process; (i) mother cell-biased segregation of aggregated proteins during cytokinesis, (ii) Text removed from public version (iii) an age-related decline in proteasome function. The first process explains why aggregates, once formed, by necessity must accumulate in aging mother cells. This asymmetric inheritance is the result of Hsp104-containing aggregates associating with the actin cytoskeleton, which effectively hinders movement of aggregates into the daughter cell. In addition, actintethered aggregates display retrograde transport towards the mother cell providing the daughter cell with the means of clearing itself of aggregates. But why do aggregates form upon cellular aging? The data presented herein indicate that Text removed from public version – The third process underlying aggregate accumulation includes a functional decline of the ubiquitin-proteasome-system, UPS. Experiments using a model in vivo UPSsubstrate revealed that 26S proteasome function is greatly diminished in aged cells, an impediment which can be restored by elevating protein disaggregation. The data suggest that the accrual of aggregated proteins obstructs proper UPS function resulting in a negative proteostasis feedback loop. Finally, Text removed from public version and proteasome function generated an extension in lifespan, enhanced disaggregation does not, suggesting that it may be more beneficial for the cell to prevent aggregates from forming than eliminating the ones already formed. Thus, aggregate-precursors may be the initial culprits in ageassociated proteostasis decline.
Enhancement of viral production by addition of nitrogen or nitrogen plus carbon in subtropical surface waters of the South Pacific

We tested the hypothesis that viral production is limited by nutrient availability in oligotrophic subtropical surface waters of the South Pacific. Nutrient (C, N, P) addition experiments were conducted at 2 stations (Stn SX18, 39° 60' S, 169° 60'W; Stn SX22, 19° 60' S, 169° 60'W) to exam- ine the responses of viral production ( 3 H-thymidine incorporation) and related variables in bottle- contained surface waters. At Stn SX18, viral production was enhanced in bottles amended with N and C with concomitant increases in bacterial production and growth, suggesting that both viral and bacterial production were co-limited by N and C. At Stn SX22, additions of N accelerated viral production with no consistent response of bacterial production, which might be an indication that prophage production was induced due to the alleviation in N limitation of host bacteria. In both experiments, nutrient-induced increases in viral production were not accompanied by increases in viral abundance, suggesting a possibility that viral production was balanced by loss. Our results suggest that viral production is limited by the availability of N or N+C in subtropical waters of the South Pacific, implying that viruses affect the mode of nutrient-induced changes in bacterial produc- tion and microbial trophic transfers in oligotrophic oceanic waters.
H2O2 Enables Convenient Removal of RAFT End-Groups from Block Copolymer Nano-Objects Prepared via Polymerization-Induced Self-Assembly in Water

RAFT-synthesized polymers are typically colored and malodorous due to the presence of the sulfur-based RAFT end-group(s). In principle, RAFT end-groups can be removed by treating molecularly dissolved copolymer chains with excess free radical initiators, amines, or oxidants. Herein we report a convenient method for the removal of RAFT end-groups from aqueous dispersions of diblock copolymer nano-objects using H2O2. This oxidant is relatively cheap, has minimal impact on the copolymer morphology, and produces benign side products that can be readily removed via dialysis. We investigate the efficiency of end-group removal for various diblock copolymer nano-objects prepared with either dithiobenzoate- or trithiocarbonate-based RAFT chain transfer agents. The advantage of using UV GPC rather than UV spectroscopy is demonstrated for assessing both the kinetics and extent of end-group removal.
Title LUOPAN : Light Utility-Oriented Placement of Actuator Nodes inSensor / Actuator Networks

We develop a light utility-oriented placement of actuator nodes (LUOPAN) for wireless sensor/actuator networks (WSAN) to spread serving duties among actuator nodes (ANs). Through appropriate placement of ANs and allocation of serving duties, system deployment cost can be reduced, and the system longevity can be improved. By considering utility consumption and geographic distribution of required services, LUOPAN outperforms existing strategies (e.g. area coverage approach and greedy approach) in terms of operation efficiency and setup cost. A mixed integer linear programming is used to obtain an optimal solution in a discretized search space, with considerations of service fading and multi-scenario placements.
PLANT PATHOLOGY & NEMATOLOGY Detecting Cotton Boll Rot with an Electronic Nose

A non-traditional disease of cotton, Gossypium hirsutum L. , was first reported in South Carolina in 1999 and can be caused by opportunistic strains of the bacterium Pantoea agglomerans (Ewing and Fife). Unlike typical fungal diseases, bolls infected with P. agglomerans continue to appear normal externally, complicating early and rapid detection of diseased bolls. We examined the use of a commercially-available electronic nose (e-nose) to distinguish between liquid Luria Bertani (LB) cultures of P. agglomerans and another non-traditional, opportunistic bacterial boll pathogen, Klebsiella pneumoniae (Schroeter). We also examined whether the e-nose could accurately discriminate between P. agglomerans infected and non-infected bolls. The e-nose was trained to recognize headspace collections of volatiles emitted from treatments established in each experiment. Cross-validation of the training data sets indicated the smell prints of the LB medium and each species of bacteria cultured in the medium could be discriminated with 69% accuracy. However, upon testing samples of each treatment solution, only 49% of the samples were correctly identified. In the second experiment, cross-validation of the training set indicated the smell prints of P. agglomeransinfected and non-infected bolls at one and two weeks post-infection could be distinguished with 62.5% accuracy. However, upon testing the discrimination accuracy of the e-nose, < 30% of the test bolls were correctly classified. In light of the marginal performance of the Cyranose 320 in our experiments, vast improvements in the discriminatory accuracy of this particular e-nose is needed before it can be recommended and adopted as a cotton crop disease management tool.
Title : Software defined cognitive networking : supporting intelligent online video streaming

Adaptive media such as HTTP adaptive streaming (HAS) is becoming a standard tool for online video distribution. The non-cooperative competition of network resources between a growing number of adaptive streaming applications has a significant detrimental impact on the user experience and network efficiency. Existing network infrastructures often prioritise fast packet forwarding and not the quality of the delivered content. Future network management must leverage application and userlevel cognitive factors to allocate scarce network resources effectively and intelligently. Our software defined cognitive networking (SDCN) project aims at incorporating new developments in human cognition, media technology and communication networks to ensure the user experience, user-level fairness and network efficiency of online adaptive media.
The Cultural-Historical Approach in Psychology : A Research Program ?

Most philosophers of science have been rather reluctant to consider psychology a 'Veal," mature science. Examples of this attitude can be found in the work of prominent philosophers such as Popper, Kühn, and Lakatos. The implicit or explicit assumption in their writings seems to be that standard examples of rational scientific development are mostly to be found in the natural sciences. Time and again we meet the worn-out cases of Galileo's new mechanics, Newton's gravitational theory and Bohr's theory of the atom. Psychology and the humanities seem to fall short of standards of rationality taken from these periods of history in the natural sciences. Therefore, psychology is considered to be an immature, unscientific or '^«paradigmatic" science.
Abscisic acid and salicylic acid seed treatment as potent inducer of drought tolerance in wheat (Triticum aestivum L.)

Two experiments were conducted to study the abscisic (ABA) acid and salicylic acid (SA) seed soaking induced regulatory role on protein content, soluble sugars, membrane stability index (MSI) and protein profiling through SDSPAGE in two wheat varieties viz.,Wafaq-2001 and Punjab-96. In the pot study significant interaction between treatments and cultivars for soluble protein content was observed where drought stress and Drought + ABA caused increase in soluble proteins in cv. Wafaq-2001. There occurred decrease in MSI (%) in Punjab-96 whereas the effects of ABA and SA were at par to increase the MSI (%). The soluble sugar contents significantly increased under drought stress. Drought + ABA and Drought + SA caused 29% and 37% increase in soluble sugars of Wafaq-2001 respectively. Protein profiling through SDSPAGE revealed the presence of polypeptides of 18, 25 and 38 kDa under drought and control in both the cultivars. ABA seed treatment induced a new protein of 18 kDa in cv. Punjab-96. Similarly; SA treatment induced a new protein of 45 kDa in the same cultivar under drought stress. The beneficial effects of ABA and SA pre-soaking were also reflected in the form of increased grain yield. Results of the current research investigation provide new insights that can lead to a better understanding of the molecular basis of drought-sensitivity in wheat and its possible mitigation by ABA and SA seed treatments. Therefore, the current findings could be used by plant breeders to develop drought resistant as well as ABA and SA responsive wheat cultivars, in order to improve the wheat yield in the dry areas.
Seasonal variation in acoustic signals of Pileated Woodpeckers

Abstract We used remote recorders to document temporal variation in acoustic signals of a population of Pileated Woodpeckers (Dryocopus pileatus) along the Choctawhatchee River in the Florida Panhandle, sampling seven different locations for 24 hrs once a week between mid January and mid April 2006. We found significant seasonal variation in the drumming behavior and vocal behavior of Pileated Woodpeckers. Drumming behavior peaked in mid March, just prior to onset of breeding activities. The three primary long-distance Pileated Woodpecker vocalizations, the cackle call, the wuk series call, and the wok call had similar patterns of seasonal variation. All four acoustic signals declined to low levels by early April when birds were nesting. The seasonal pattern of variation for all four Pileated Woodpecker acoustic signals had a similar pattern to that observed for song in many temperate passerines, and support the hypothesis that woodpecker calls and drumming displays are the functional counterparts to passerine song.
Cortical Activity Changes after Art Making and Rote Motor Movement as Measured by EEG: A Preliminary Study

iii. The art making process and the artwork itself are integral components of treatment that help to understand and elicit verbal and nonverbal communication within an attuned therapeutic relationship [1]. However, without empirical evidence to prove these tenets, art therapists must rely on interpretive frameworks, which are often idiographic and do not allow generalizations to be made to larger populations.
Intellectual Functioning of Individuals with Mental Disorders on Wechsler Adult Intelligence Scale -Revised (WAIS -R)

The purpose of present research was to evaluate the intellectual functioning of individuals suffering from Major Depressive Disorder, Obsessive Compulsive disorder and Schizophrenia. After detailed literature review it was hypothesized that the mean full scale IQ score of adults with Obsessive Compulsive disorder will be higher than the mean full-scale IQ score of adults with (i) Schizophrenia and (ii) Depression. Since the previous century research work has been started on intelligence investigating how it is related to psychiatric disorders e.g Goodman and Graham, (1996) found psychiatric problems as the strongest consistent predictor of intelligence quotient (IQ). Further several other researchers found the effects of psychological disorders on intellectual functions (Tallis et al. 1999; Savage et al. 2000; Zitterl et al, 2001; Tuna et al. 2005). Through purposive sampling technique; considering the independent group design, a sample of 90 (30 in each group) was selected from different psychiatric clinics and hospitals of Karachi- Pakistan. The age range was from 16 to 50 years (mean age=31.5 years). Their education level was Intermediate to Masters. After taking the consent from the authorities their diagnoses were taken from the concerned files. The Wechsler Adult Intelligence Scale (WAIS-R, Wechsler, 1981) was administered to assess the intellectual functioning of the patients, followed by Intake card and Case History Sheet of Institute of Clinical Psychology, University of Karachi. In order to interpret the results in statistical terminology t-test and ANOVA were computed. It was indicated that there is a significant difference between mean Full scale IQ scores of adults with Obsessive compulsive disorder (OCD) and schizophrenia. However an insignificant difference was found between mean full scale IQ scores of adults with Major Depressive disorder and Obsessive compulsive disorder (OCD). Implication of the findings have also discussed.
AM Modelling Energy Consumption in China

Energy consumption in China has attracted conside rabl research interest since the middle 1990s. This is largely prompted by the environment al ramifications of the extensive use of fossil fue ls in the country to propel two decades of high economic growth. Since the late 1980s, there has been an increasing awareness on the part of the Chinese gov rnment of the imperative for the balance of econom ic growth and environmental protection. The governmen t has since taken various measures ranging from encouraging energy-saving practice, controlling was te discharges to financing R & D programs on improving energy efficiency. Against this backdrop has seen a constant decline of the energy intensit y of the economy, measured as the ratio of total energy consumed in standard coal equivalent to the real GD P since 1989. Using the 1987 and 1997 input-output t ables for China, the present study examines the imp act of technical and structural changes in the economy n industry fuel consumption over the 10-year perio d. Technical changes are reflected in changes in direc t input-output coefficients, which capture the tech ni al evolvement of intermediate production processes. S tructural changes refer to shifts in the pattern of final demand for energy, including the import and export c mposition of various fuels. Six fuels are includ ed in the study, namely, coal, oil, natural gas, electric ity, petroleum and coke and gas, which cover all of the energy types available in the input-output tables. It is found that the predominant force of falling energy intensity was changes in direct energy input requir ements in various industries. Such changes were responsible for a reduction in the consumption of f our of the six fuels per unit of total output. Str uctural changes were not conducive for improving energy eff ici ncy. These findings are consistent with previo us studies, which used shorter timeframes of data. Ho wever, unlike the previous studies, technical chang es are differentiated between direct and total input r equirements. This allows the separation of the imp acts on energy use of energy-saving technologies in the pro duction process and of the externalities of such technologies due to input-output linkages.
D COORDINATE TRANSFORMATION USING TOTAL LEAST SQUARES

Nowadays, there are efforts around the globe to coordinate all mapping activities using the earth-centred WGS 84. Therefore the need to transform Nigerian coordinates hitherto based on the Nigerian non-earth centred Minna Datum to the global WGS 84. This research presents a 3D coordinate transformation between the local Minna Datum and the global WGS 84 datum in Nigeria using total least squares. The Bursa-Wolf and Molodensky-Badekas similarity/conformal transformation models are used for the experiment. One hundred and ten points are selected, of which sixty points are used to compute the values of the unknown parameters while the remaining fifty points are used to compute the accuracy of the model. The experiment shows that total least squares yields better result than the least squares; and also that the Molodensky-Badekas model results are better than those of the Bursa-Wolf model.
Monetary and fiscal policy shocks and economic growth in Kenya: VAR econometric approach

In macroeconomic policy design and management, monetary and fiscal policies are of great essence. However, the relative effectiveness of these policies has been subject to debate in both theoretical and practical realms for a long period of time. This paper investigated the relative potency of the policies in altering real output in Kenya using a recursive vector autoregressive (VAR) framework. The analysis of variance decomposition and impulse response functions reveled that fiscal policy has a significant positive impact on real output growth in Kenya while monetary policy shocks are completely insignificant with fiscal policy shock significantly alters the real output for a period of almost eight quarters.
ASYMPTOMATIC MALARIA IN TRENGGALEK DISTRICT, EAST JAVA PROVINCE AS REVEALED BY MICROSCOPIC EXAMINATION AND SINGLE STEP PCR

Trenggalek district is one of hypoendemic areas of malaria in East Java Province. Most of the malaria cases are imported fromendemic areas in outside of Java Island, as the destination of the seasonal migratory workers. When they return to Trenggalekdistrict usually they are infected with malaria. Blood examination has been done to the patients who have recovered from malariainfection in order to find out the asymptomatic malaria in this region. The examination of Giemsa-stained blood smear is a goldstandard method recommended by WHO. However, due to the very low parasitemia in asymptomatic malaria makes difficulty inmicroscopic examination, the molecular diagnosis by single step PCR in this research is aimed to confirm the results of microscopicexamination of asymptomatic malaria. The objective of this paper was to find out malaria asymptomatic in Dongko sub-district,Trenggalek district by microscopic examination and single step PCR methods. Blood samples were collected during May andSeptember 2012 from the patients who have recovered from malaria infection. The number of sample was according to the list ofpatients hospitalized in Pandean public health service (Puskesmas Pandean), Dongko sub-district, Pandean district, East Javaprovince. Microscopic diagnosis was done on Giemsa-stained thick and thin smears at 1000x magnification. Molecular diagnosiswas done by single step PCR method according to Patsoula et al (2002). During May and September 2012, asymptomatic malariahave been found, where of the 18 samples, 5 samples were positive by microscopic examination two for P. falciparum, two for P.vivax, one for mix of both species, and 13 samples were negative. Single step PCR diagnosed two samples P. falciparum, twosamples as P. vivax, 6 samples as mix infection and 6 as negative samples. In conclusion, single step PCR provides a sensitive toolfor detection extremely low level of parasitemia in asymptomatic malaria. Mass screening of asymptomatic malaria is needed to beperformed simultaneously in collaboration with research institute or research hospital prior to mapping the cases and earlymedication. The presence of asymptomatic malaria cases is a challenge for the management of malaria elimination program in anyendemic area including Trenggalek District. (FMI 2013;49 150-154)
Autolysis of thermophilic lactobacilli and dairy propionibacteria: a review

Summary - The peptidases and esteras es of thennophilic lactobacilli and dairy propionibacteria, which are known to participate in the ripening of Swiss-type cheeses, are mainly intracellular. Their release in cheeses requires a necessary autolytic event. The aim of this review is to summarize the CUITentknowledge on autolysis of cheese-related thennophilic lactobacilli and dairy propionibacteria, focussing in particular on the preliminary demonstration of autolysis in cheese-like substrates, the strain-dependence of autolysis, the biochemical characterization of the autolysins involved, and the effect of environmental parameters such as pH, temperature and ionie strength on the maximal extent of autolysis. Further issues in this research area will also be discussed.
Does Tourism-led Growth Hypothesis Exist in Pakistan? A Fresh look from Combine Cointegration and Causality Approach with Structural Breaks

Purpose: The prime objective of this study is to re-investigate the tourism-led growth hypothesis by accommodating structural breaks over the annual period 1988-2014 for Pakistan. This study used two measure of tourism development -tourist arrivals and tourism expenditure per capita to explore the relationship between tourism and economic growth. Methodology: The unit root problem is tested by applying Ng-Perron unit root test. However, Perron, (1997) single structural break and Clemente et al. (1998) double structural breaks unit root tests also employed. To examine the long relationship between tourism and economic growth, we applied newly invented Bayer-Hanck, (2013) combine cointegration approach in the presence of structural breaks. The robustness of combine cointegration approach is tested by Johansen cointegration technique. Further, VECM Granger causality is used to understand the direction of causality during structural shocks. Findings: We found all data series stationary at first difference. The empirics confirm the existence of long run relationship between underlying variables in the presence of structural breaks. The results of VECM Granger causality predicted unidirectional causality running from tourism development (tourist arrives) to economic growth in long run as well as short run when. But, bidirectional relationship between tourism development (tourism expenditure) and economic growth has found. This validates the tourism-led growth for Pakistan. Recommendations: Policy makers should focus on development of tourism industry to enhance economic growth for Pakistan.