Miracle-dz/UniFAR-FTUs huggingface dataset:
Uma Investigação da Avaliação Emocional por Intenção e por Valores Humanos Expressos em Postagens de Usuários no Twitter (An Investigation of Emotional Evaluation of User Posts on Twitter Based on Intention and Expressed Human Values)

The UX evaluation, using user ́s texts, has recently been performed by IHC researchers. However, they invite the user to write about their usage experience and then analyze their texts in order to investigate the UX in the evaluated system. Although these evaluations investigate, from the identification of the context of use of the system to the identification of UX goals to evaluate a system, the spontaneous reporting of its users are unreasonable: the human values (personal and social) expressed in users' texts, and; their intention to report their use in the system. In this paper, an investigation is conducted to evaluate UX in 3,880 posts extracted from Twitter, considers users' spontaneous experience reports, investigating: there is a relationship between the user's intention to report their use in the system and the values expressed by them during an interaction? Results of this paper showed there is a relationship between the user's intention of emotion to post a message about the system and her/his values that can be important to the analysis of UX.
Mitochondrial damage pathways in ventilator induced lung injury (VILI): an update

Although reduced tidal volumes have improved patient survival during ventilation for acute lung injury, further improvements will require pharmacologic interventions of the cellular pathways for inflammation and injury. We previously reported that pretreatment with mitochondrial targeted mtDNA repair enzymes largely prevented lung injury and inflammation during a protocol for moderately severe ventilation induced lung injury. GSH/GSSG ratios indicated that free radical production had been reduced to baseline levels by treatment. The central role of the alveolar macrophages and cellular mechanisms of injury are discussed. This includes a rapid calcium entry and mitochondrial production of excessive reactive oxygen species. Excessive ROS can then result in activation of the NLRP3 inflammasome and secretion of IL-1 and IL-18 by caspase-1. A simultaneous activation of NFkB to transcribe pro forms of the cytokines is stimulated by damage associated molecular pattern (DAMP) recognition receptors. These are primarily TLR4 responding to various cellular damage products and TLR9 responding to mtDNA fragments that appear to be primarily involved. Intervention in these pathways could result in useful future clinical treatments.
Error propagation control in Laplacian mesh compression

Laplacian mesh compression, also known as high‐pass mesh coding, is a popular technique for efficiently storing both static and dynamic triangle meshes that gained further recognition with the advent of perceptual mesh distortion evaluation metrics. Currently, the usual rule of thumb that drives the decision for a mesh compression algorithm is whether or not accuracy in absolute scale is required: Laplacian mesh encoding is chosen when perceptual quality is the main objective, while other techniques provide better results in terms of mechanistic error measures such as mean squared error.
Slc26a3 deficiency is associated with epididymis dysplasia and impaired sperm fertilization potential in the mouse

Members of the solute carrier 26 (SLC26) family have emerged as important players in mediating anions fluxes across the plasma membrane of epithelial cells, in cooperation with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. Among them, SLC26A3 acts as a chloride/bicarbonate exchanger, highly expressed in the gastrointestinal, pancreatic and renal tissues. In humans, mutations in the SLC26A3 gene were shown to induce congenital chloride‐losing diarrhea (CLD), a rare autosomal recessive disorder characterized by life‐long secretory diarrhea. In view of some reports indicating subfertility in some male CLD patients together with SLC26‐A3 and ‐A6 expression in the male genital tract and sperm cells, we analyzed the male reproductive parameters and functions of SLC26A3 deficient mice, which were previously reported to display CLD gastro‐intestinal features. We show that in contrast to Slc26a6, deletion of Slc26a3 is associated with severe lesions and abnormal cytoarchitecture of the epididymis, together with sperm quantitative, morphological and functional defects, which altogether compromised male fertility. Overall, our work provides new insight into the pathophysiological mechanisms that may alter the reproductive functions and lead to male subfertility in CLD patients, with a phenotype reminiscent of that induced by CFTR deficiency in the male genital tract.
Current nomenclatural changes in Cordyceps sensu lato and its multidisciplinary impacts

ABSTRACT Innumerable name changes have occurred in Cordyceps and allied taxa, after the phylogenetic classification of Cordyceps, coupled by the application of one fungus one name after the amendment of ICN. Complying with one fungus one name, many generic names have been protected for monophyletic clades in Clavicipitaceae and Ophiocordycipitaceae that have made tremendous transfer of Cordyceps spp. to both sexual and asexual genera. Species compositions of the accepted genera Ophiocordyceps, Tolypocladium, Metarhizium, Perennicordyceps, Polycephalomyces and Purpureocillium are briefly discussed to update the readers with the current placements of Cordyceps spp. Some examples of frequent name changes of Cordyceps spp. are also mentioned, with reference to use of older scientific names in non-mycological publications.
LRH-1 drives hepatocellular carcinoma partially through induction of c-myc and cyclin E1, and suppression of p21

Background To explore potential therapeutic target is one of the areas of great interest in both clinical and basic hepatocellular carcinoma (HCC) studies. Nuclear receptor liver receptor homolog-1 (LRH-1, NR5A2) is proved to play a positive role in several cancers including breast cancer, pancreatic cancer and intestinal cancer in recent years. However, the exact role of LRH-1 in the development and progression of HCC is not fully elucidated. Methods The LRH-1 expression level in HCC clinical samples was examined by immunohis-tochemistry (IHC). Stable LRH-1-suppressed HepG2 clones (HepG2LRH-1/-) were generated by transcription activator-like effector nucleases (TALENs) and both in vitro and in vivo experiments were conducted. Results We confirmed that LRH-1 showed an increased expression pattern in HCC clinical samples. Our in vitro and in vivo results indicated that suppression of LRH-1 in HepG2 significantly attenuated its proliferation rate and tumorigenic capacity. Gene expression microarray analysis indicated that LRH-1mostly regulated gene expression involved in cell cycle. In addition, our gain-of-function experiments indicated that ectopic expression of LRH-1 dramatically induced the mRNA and protein levels of c-myc and cyclin E1, while attenuating the expression of p21. Conclusion Our results suggest that LRH-1 might be a potential therapeutic target for clinical HCC treatment.
Tagging patterns in a derived community of interests within a social bookmarking site

This study is aimed to improve our understanding of the tagging phenomenon by adopting a new approach to collecting and analyzing data. We argue that both people’s tagging behavior and the structure of tag data can be better understood within a clearly defined context that establishes the boundaries of data collection and analysis. The context used in this particular study is a community of interests derived from user activities within a social bookmarking site. Building upon a previous study (Oh, 2010), which identified communities of shared interests among active users of delicious.com using network analytic techniques, we collect and analyze tag data with reference to a specific community of shared interests. CONTEXT AND MOTIVATION
Drug repurposing: Ibrutinib exhibits immunosuppressive potential in organ transplantation

Long-term administration of classic immunosuppressants can induce severe adverse effects. The development of novel immunosuppressants confronts great challenges and opportunities. Ibrutinib, an approved drug for B-cell lineages and chronic graft versus host disease (cGVHD), exhibits immunosuppressive efficacy in autoimmune diseases. Ibrutinib's potential as an immunosuppressant in organ transplantation has not been investigated to date. In a xeno-artery patch model ex vivo, ibrutinib inhibited the proliferation of PBMCs (POD 14-42), mainly CD3+CD4+ and CD3+CD8+ T cells ex vivo. The secretion of cytokines (IL-6, IL-2 and IFN-γ) was suppressed in response to ibrutinib. In allo-skin transplantation models, ibrutinib delayed the rejection of grafted skins. Ibrutinib decreased the amount of T/B cells and lymphocyte infiltration. Altogether, ibrutinib exhibited immunosuppressive potential through cytokine regulation and T cell inhibition ex vivo and in vitro. Repositioning of ibrutinib as an immunosuppressant will greatly facilitate novel immunosuppressant development.
A Quick and Automatic Image Based Modeling and Rendering System

We present a complete and automatic system for object capture from video, Internet delivery, and real-time photorealistic rendering. Shape from silhouette is used to capture an approximate enveloping geometry, the visual hull. Texture coordinates are generated automatically under a minimum distortion criterion. To account for the difference between the true shape of the object and the captured visual hull we use Dynamic texturing, a viewdependent texturing method, which explicitly captures geometric deviations and applies a texture based correction. These models are then efficiently coded, and delivered over the Internet.
Spotlight on math anxiety

Anxiety disorders are some of the most widespread mental health issues worldwide. In educational settings, individuals may suffer from specific forms of test and performance anxiety that are connected to a knowledge domain. Unquestionably, the most prominent of these is math anxiety. Math anxiety is a widespread problem for all ages across the globe. In the international assessments of the Programme for International Student Assessment (PISA) studies, a majority of adolescents report worry and tension in math classes and when doing math. To understand how math anxiety takes effect, it has to be regarded as a variable within an ensemble of interacting variables. There are antecedents that facilitate the development of math anxiety. They concern environmental factors such as teachers’ and parents’ attitudes toward their students’ and children’s ability in math, societal stereotypes (eg, on females’ math abilities), or personal factors such as traits or gender. These antecedents influence a number of variables that are important in learning processes. Math anxiety interacts with variables such as self-efficacy or motivation in math, which can intensify or counteract math anxiety. Outcomes of math anxiety concern not only performance in math-related situations, they can also have long-term effects that involve efficient (or not-so-efficient) learning as well as course and even vocational choices. How can math anxiety be counteracted? A first step lies in its correct diagnosis. Questionnaires for the assessment of math anxiety exist for all age groups, starting at primary education level. Help against math anxiety can be offered on different levels: by educational institutions, by teachers and a change in instructional approaches, by parents, or by the affected person. However, much more research is needed to develop effective measures against math anxiety that are tailored to an individual’s characteristics and needs.
Treatment of post-craniotomy acute severe supraorbital neuralgia using ultrasound-guided pulsed radiofrequency: a case report

Pulsed radiofrequency is an effective, safe, and nondestructive pain treatment technique that has been insufficiently reported in the treatment of supraorbital neuralgia. We report the successful use of pulsed radiofrequency to alleviate acute severe supraorbital neuralgia in a post-craniotomy patient. A 52-year-old female, who had acute severe supraorbital neuralgia after having received a right frontal craniotomy and with poor efficacy in response to medication and a nerve block, was subjected to ultrasound-guided pulsed radiofrequency treatment and experienced complete pain relief, as a result of which the patient stopped taking all analgesic drugs. The patient had follow-up visits for 1 year, during which she reported no pain. Furthermore, no side effects of nerve damage after pulsed radiofrequency were observed. Our results suggest that pulsed radiofrequency is a promising technique for the treatment of supraorbital neuralgia and that further studies of this technique should be conducted.
Prevalence and Distribution of HPV Genotypes in 1387 Women with Cervical Intraepithelial Neoplasia 2/3 in Shanxi Province, China

Objective: The distribution of human papillomavirus (HPV) genotypes varies by countries and regions. Data regarding HPV genotype distribution for women with cervical intraepithelial neoplasia 2/3 (CIN2/3) are still limited. This study aimed to investigate the distribution of HPV genotypes for women with CIN2/3 in Shanxi province, China. Methods: Prior HPV testing/genotyping resulted from women with histologic diagnosis of CIN2/3 were retrospectively collected between August 2011 and August 2016. Results: A total of 1387 women with a diagnosis of CIN2/3 were included in this study. The average age of the women was 45.7 years and the average time period from HPV testing to histological diagnosis was 0.4 months. The overall high-risk HPV (hrHPV) positive rate was 91.6%. In all tested women, the most commonly detected hrHPV genotype was HPV16 (59.3%) followed by HPV58 (14.4%) and HPV33 (10.0%), while HPV18 was in the 6th position (6.0%). Conclusions: This is one of the largest studies of HPV genotyping for women with CIN2/3 in China. The prevalence and distribution of HPV genotypes in these Chinese women differed from those in women from Western countries. Our results provide important information for developing specific HPV vaccines for Chinese women.
Antiangiogenic Therapy in Colorectal Cancer

Abstract Colorectal carcinoma is the third most common cancer worldwide. Approximately 20% of patients with colorectal cancer will have metastatic disease at the time of initial diagnosis, and approximately 30% to 50% of patients with primary colon cancer will relapse and die of metastatic cancer. The 5-year survival rate of metastatic colorectal cancer remains disappointing at approximately 10%. Angiogenesis plays a significant role in tumor growth and metastasis in colorectal carcinoma. There are currently 4 US Food and Drug Administration–approved antiangiogenic agents for metastatic colorectal cancer. Bevacizumab is the only antiangiogenic agent approved by the US Food and Drug Administration for first-line treatment of metastatic colorectal cancer. Other antiangiogenic agents include ramucirumab, ziv-aflibercept, and regorafenib. We review the data supporting the use of antiangiogenics in this disease.
Implementación de plataforma HPC dinámica para la resolución de problemas de alta complejidad computacional

En la actualidad existe gran cantidad de problemas que son resueltos de forma aceptable mediante la utilización de algoritmos secuenciales. Sin embargo, a medida que la complejidad del problema incrementa, las implementaciones secuenciales suelen volverse ineficientes hasta incluso obsoletas. Siendo necesario recurrir a la utilización de herramientas que permitan ofrecer resultados más eficientes. En este tipo de escenarios, la computación paralela se ha convertido en la forma tradicional de resolver gran variedad de problemas de alta complejidad computacional. Si bien existen diferentes niveles de paralelismo, la utilización de esquemas basados en múltiples computadoras es la más adecuada para tratar problemas de de este tipo. Sin embargo, el acceso a una infraestructura de alto rendimiento no siempre suele estar al alcance de todo tipo de instituciones. Debido a esto, en este trabajo se diseña una implementación de reutilización de equipamiento informático existente, para conformar un clúster HPC. La implementación de esta plataforma será la herramienta fundamental para poder trabajar de forma activa en el área de HPC, posibilitando al desarrollo y evaluación de nuevas técnicas de optimización.
Uniform Sampling for Image-based Rendering Shiny Objects

A novel sampling technique is presented, which can evenly sample all rays that pass through a rectangular surface. Different view directions are uniformly sampled based on the shape of a spiral. Projection positions are then sampled adaptively according to the view direction to provide a constant sampling rate. The experimental results show that our approach can faithfully represent shiny real objects with a reasonable number of samples. Categories and Subject Descriptors: I.3. 7 [Computer Graphics]: Three-Dimensional Graphics and Realism
Monitoring antiangiogenesis of bevacizumab in zebrafish

Bevacizumab, which is a humanized anti-VEGF antibody, has been successfully applied in clinics since 2004. Bevacizumab in combination with chemotherapy showed high safety and has been applied to solid tumors. However, studies on the insight into the mechanism about the antiangiogenesis activity of bevacizumab were mostly done on mice models, and so there are no visual and intuitive models to observe the process of antiangiogenesis. Here, we first used a zebrafish model to investigate the angiogenesis suppressing behavior of bevacizumab. Our results showed that bevacizumab inhibited formation of zebrafish subintestinal veins, which mimics the process of tumor angiogenesis in vivo. Meanwhile, bevacizumab caused specific vasculature formation defects in subintestinal veins but not in the trunk. Our study also indicated that bevacizumab could inhibit zebrafish retinal angiogenesis with therapeutic potential.
Flat-field illumination for quantitative fluorescence imaging

The uneven illumination of a Gaussian profile makes quantitative analysis highly challenging in laser-based wide-field fluorescence microscopy. Here we present flat-field illumination (FFI) where the Gaussian beam is reshaped into a uniform flat-top profile using a high-precision refractive optical component. The long working distance and high spatial coherence of FFI allows us to accomplish uniform epi and TIRF illumination for multi-color single-molecule imaging. In addition, high-throughput borderless imaging is demonstrated with minimal image overlap.
Glucose Uptake via STP Transporters Inhibits in Vitro Pollen Tube Growth in a HEXOKINASE1-Dependent Manner in Arabidopsis thaliana

Glucose is released by SWEET proteins into the apoplast of the pistil and taken up into pollen tubes by STP transporters to regulate pollen tube growth through HXK1 signaling. Pollen tube growth requires a high amount of metabolic energy and precise targeting toward the ovules. Sugars, especially glucose, can serve as nutrients and as signaling molecules. Unexpectedly, in vitro assays revealed an inhibitory effect of glucose on pollen tube elongation, contradicting the hypothesis that monosaccharide uptake is a source of nutrition for growing pollen tubes. Measurements with Förster resonance energy transfer-based nanosensors revealed that glucose is taken up into pollen tubes and that the intracellular concentration is in the low micromolar range. Pollen tubes of stp4-6-8-9-10-11 sextuple knockout plants generated by crossings and CRISPR/Cas9 showed only a weak response to glucose, indicating that glucose uptake into pollen tubes is mediated mainly by these six monosaccharide transporters of the SUGAR TRANSPORT PROTEIN (STP) family. Analyses of HEXOKINASE1 (HXK1) showed a strong expression of this gene in pollen. Together with the glucose insensitivity and altered semi-in vivo growth rate of pollen tubes from hxk1 knockout lines, this strongly suggests that glucose is an important signaling molecule for pollen tubes, is taken up by STPs, and detected by HXK1. Equimolar amounts of fructose abolish the inhibitory effect of glucose indicating that only an excess of glucose is interpreted as a signal. This provides a possible model for the discrimination of signaling and nutritional sugars.
Mitral cells and the glucagon‐like peptide 1 receptor: The sweet smell of success?

The olfactory bulb (OB) is often affected at very early stages of neurodegenerative disorders, in the so‐called “prodromal” phase. In Parkinson's disease (PD), olfactory disturbances appear years before motor symptoms arise. Additionally, pathological alpha‐synuclein aggregates are found in olfactory regions before spreading to other areas of the brain. Being positioned at the frontier between the brain and a potentially hostile environment, could explain the particular vulnerability of the OB. Mitral cells (MCs), the principal projecting neurons of the olfactory system, are involved in the pathogenesis and in the prion‐like progression of PD. They are affected by Lewy pathology and are thought to contribute to the axonal transport of misfolded alpha‐synuclein to other regions of the brain. Here, we first describe the main markers reported to distinguish MCs from other olfactory neurons. We focus on the glucagon‐like peptide 1 receptor (GLP‐1R), a membrane protein specifically expressed in MCs. After summarizing OB pathology, we explore the idea of targeting specifically MCs with GLP‐1 or its analogues. Exenatide has shown great promise as a neuroprotective and neurorestorative agent and has been used in a clinical trial for clinical PD. Since GLP‐1R activation has the ability to mitigate many facets of prodromal PD pathology, we postulate that once a robust biomarker is in place that is capable of identifying individuals in the prodromal phase of PD, homing in on GLP‐1R could assist in deferring, or eradicating to a significant degree, the clinical manifestation of this debilitating human disorder.
Synthesis of a hemin-containing copolymer as a novel immunostimulator that induces IFN-gamma production

Background Hemozoin, a chemical analog of a malarial pigment, is a crystal composed of heme dimers that can act as a potent Th1-type adjuvant, which strongly induces antibody production. However, the clinical applications of malarial hemozoin have limitations due to biosafety concerns and difficulties in the manufacturing process. Based on the premise that an analog of the heme polymer might display immunostimulatory effects, a hemin-containing polymer was developed as a novel immunostimulator. Materials and methods To synthesize the copolymer containing hemin and N-isopropylacrylamide (NIPAM), this study employed a conventional radical polymerization method using 2,2′-azodiisobutyronitrile as the radical initiator; the synthesized copolymer was designated as NIPAM-hemin. Results NIPAM-hemin was soluble and showed no cytotoxicity in vitro. The NIPAM-hemin copolymer induced the production of interferon (IFN)-γ and interleukin (IL)-6 from peripheral blood mononuclear cells, although hemin and the NIPAM monomer individually did not induce the production of any cytokines. The production of IFN-γ induced by NIPAM-hemin was independent of toll-like receptor 9 and the NLRP3 inflammasome pathway. Conclusion Given that NIPAM-hemin induced IL-6 and IFN-γ production in immune cells without any cytotoxic effects, NIPAM-hemin has potential therapeutic applications as a Th1-type adjuvant.