Miracle-dz/UniFAR-FTUs huggingface dataset:
Case Report: The role of intradermal micro‐droplet hyaluronic acid injection in the correction of filler nodules complication

Filler injection has been widely used as a non‐surgical intervention for skin rejuvenation and augmentation for the past decade. Hyaluronic acid (HA) is considered the most common treated material with high safety profile. Various mechanisms, including promoting collagen synthesis are postulated the efficacy of this powerful skin rejuvenation. The greater number of its used, the more complications were seen. Among the non‐vascular complications from filler injection, the most frequent one is nodule formation. It could occur as early or late onset even with HA injection. One of the causes of these nodule formation is from poor injection technique leading to visible skin beads and lumps. The current treatments of these filler side effects mainly aim to remove or reduce excessive or displaced filler product. To the best of our knowledge, there has been no report of using the intradermal injection of the micro‐droplet HA to correct filler nodule and simultaneously revitalize the skin quality. This novel treatment technique could be a safe alternative for nodule formation correction.
Understanding the Treatment Algorithm of Patients with Metastatic Pancreatic Neuroendocrine Neoplasms: A Single-Institution Retrospective Analysis Comparing Outcomes of Chemotherapy, Molecular Targeted Therapy, and Peptide Receptor Radionuclide Therapy in 255 Patients

Background: The number of therapeutic options for patients with pancreatic neuroendocrine neoplasms (PNEN) has increased, but the optimal therapeutic algorithm has not been defined due to lack of randomised trials comparing different modalities. Methods: We performed a retrospective study in patients with metastatic PNEN treated with ≥1 line of systemic therapy. The relationship between baseline characteristics, treatment type, and time to treatment failure (TTF), time to progression (TTP), and overall survival (OS) was analysed using the Kaplan-Meier method. Univariate and multivariate analyses were performed using the Cox proportional hazards model. Results: Two hundred and fifty-five patients with metastatic PNEN had 491 evaluable lines of therapy. Independent predictors of TTF included treatment type, Ki-67, tumour grade, and chromogranin A. To reduce selection bias, a subgroup of 114 patients with grade 2 (G2) metastatic pancreatic neuroendocrine tumours (PNET) was analysed separately. These patients had received 234 lines of treatment (105 chemotherapy, 82 molecular targeted therapy, and 47 peptide receptor radionuclide therapy [PRRT]). In the G2 cohort, TTF and TTP were superior for PRRT compared with both chemotherapy and molecular targeted therapy. OS in the G2 cohort was also superior for those that had received PRRT compared with those that had not (median 84 vs. 56 months; HR 0.55, 95% CI: 0.31–0.98, p = 0.04). Conclusions: This study suggests that PRRT is associated with superior clinical outcomes relative to other systemic therapies for G2 metastatic PNET. Prospective studies are required to confirm these observations.
Mento‐buccal bilobed flap for closure of large defects of the cheek and temple

The frequency of skin tumors of the head and neck region is constantly growing. This is largely due to the ever-increasing average age of the patients, the greater incidence of actinic damage in the course of life and to immunosuppression in the context of organ transplants [1]. Very large defects, which include both the cheek and temple regions, can often only be closed by transplants or free flaps. Transplants carry the risk of graft contraction with various resulting functional side effects (e.g. ectropion). In addition, the cosmetic result is often unsatisfactory [2]. In the case of a free flap, not only is a donor site required, but also several hours of complex surgery with increased risk. In patients with constitutive excess of submental skin, an alternative is to use a mento-buccal bilobed-flap (double pedicled flap) to close even large defects on the cheek and, if necessary, the lower temporal parts.
The Impact of Smoking Cessation and Continuation on Recurrence and Survival in Patients with Head and Neck Cancer: A Systematic Review of the Literature

Background: The impact of smoking continuation or cessation on the outcome of head and neck cancer (HNC) patients concerning recurrence and survival rates is not well understood. We aimed to analyze the prognostic role of smoking habits in patients with newly diagnosed HNC and the effects on survival, recurrence rates, and second primary tumor (SPT) development. Methods: A systematic literature review of the databases PubMed and Web of Science was performed in October 2019 using the search words “head and neck cancer” and “smoking cessation. ” Articles analyzing the effects of ongoing smoking or smoking cessation in HNC patients were included. Results: Twelve studies published from 1993 to 2016 including 6,308 patients with HNC of stages I–IV were eligible for analysis. The median follow-up was 5 years. Six of 8 studies revealed an improved outcome concerning the median overall survival or survival rates favoring smoking cessation. Regarding recurrence rates, 5 of 6 studies indicated a statistically significant benefit associated with smoking cessation, and 2 of 3 studies showed a lower risk for SPT associated with postdiagnosis smoking cessation. Conclusion: Smoking cessation in patients with newly diagnosed HNC is associated with improved outcomes concerning overall survival, recurrence rates, and SPTs. Further research is needed to validate these results and to evaluate the specific effects on different tumor types and treatment approaches.
A life-threatening floor of the mouth hematoma secondary to explantation attempt in the anterior mandible.

Implant dentistry is considered to be a safe and routine surgical procedure. However, cases of life-threatening hematoma of the floor of the mouth resulting in airway obstruction were previously reported as a complication of implant placement in the anterior mandible. Massive bleeding in this anatomical site may be caused by perforating the lingual cortex and/or damaging the lingual perimandibular vessels. In the long term, dental implants can fail, mainly due to peri-implantitis, and must be removed. Explantation procedure may occasionally become a complex challenge, with a risk for various complications. Case report: This report presents the first case of life-threatening hematoma of the floor of the mouth, as a complication secondary to a failed attempt of dental implant removal at the anterior mandible. The proximity of the implant to the lingual vascular canal might have served as a cause for vascular damage during explantation. Conclusions: Implant removal complications are scarcely described in the literature. Nonetheless, damaging blood vessels during explantation should not be underestimated. Computed tomography (CT) may be of value not only in preoperative implant planning but also before implant removal in jeopardized anatomical zones such as the anterior mandible. Lingual vascular canals should be looked for on computed tomography scans.
The incidence and economic impact of aggression in closed long-stay psychiatric wards

Abstract Objective Aggressive behaviour is highly prevalent in long-term psychiatric inpatient care. We aimed to estimate the overall incidence of aggression, the time staff took to handle aggression incidents, and the weighted average financial costs thereof. Methods A random sampling procedure was conducted at long-term psychiatric inpatient care facilities. Nurses were asked to recall all incidents (i.e., verbal, physical towards objects, self, or others) of their shift. For the time spent on each type of incident, staff were monitored in real-time. Estimated costs were calculated by the time spent multiplied by hourly wages in addition to material-related costs. Results Incidence rates were 90 incidents per patient year. The average time spent per incident was 125 min but differed for each type of incident. Almost 80% of this time was consumed by nursing staff. The average cost per aggression incident was €78; extrapolated per patient year, the total costs were approximately €7000. Conclusions The current study found a high rate of aggression incidents in closed long-stay psychiatric wards. Reports of aggression on these types of wards are scarce. Nevertheless, aggression seems to have a severe impact on invested time and related costs, which suggests a need for aggression-prevention and de-escalating programs. Key points Aggression incidents are highly prevalent and are accompanied by high costs. The effect of aggression incidents on the workload for staff members is high, especially for nursing staff. Studies across countries on the incidence and the costs of aggression among psychiatric inpatients are needed to help model the effects of (new) strategies for aggression reduction.
Diffuse brain connectivity changes in Charcot–Marie–Tooth type 1a patients: a resting‐state functional magnetic resonance imaging study

Changes of brain structure and function have been described in peripheral neuropathies. The aim of our study was to systematically investigate possible modifications of major large‐scale brain networks using resting‐state functional magnetic resonance imaging (RS‐fMRI) in Charcot–Marie–Tooth disease type 1A (CMT1A) patients.
Developmental and epilepsy spectrum of KCNB1 encephalopathy with long-term outcome

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Developmental and epilepsy spectrum of KCNB1 encephalopathy with long-term outcome Claire Bar, Mathieu Kuchenbuch, Giulia Barcia, Amy Schneider, Mélanie Jennesson, Gwenaël Le Guyader, Gaetan Lesca, Cyril Mignot, Martino Montomoli, Elena Parrini, et al.
Pretreatment of hardwood chips via autohydrolysis supported by acetic and formic acid

Abstract A mixture of US southern hardwood chips was treated with aqueous acetic and formic acid (FA) solutions in a modified Dionex ASE100 extractor. The amount and selectivity of hemicelluloses dissolution increase at higher acetic acid (AA) and FA concentrations, but cellulose remains intact in the residual wood. Even at the highest AA concentration of 100 g l-1, the dissolved hemicellulose fragments are still oligomeric except for arabinose. The formation of lignin-like condensation products (LCPs) and decomposition of dissolved mannose, arabinose, and galactose were observed at the highest AA concentration. Sugar hydrolysis is more pronounced with the addition of FA at increasing temperature. The concentration of xylose in the FA extract is approximately the same as that of xylo-oligomers at 160°C. Formation of LCPs is only observed at 170°C during 10 g l-1 FA treatment. The concentrations of dissolved wood components increase linearly with increased recycling of the FA extract.
Seeing the fetus from a DOHaD perspective: discussion paper from the advanced imaging techniques of DOHaD applications workshop held at the 2019 DOHaD World Congress

Abstract Advanced imaging techniques are enhancing research capacity focussed on the developmental origins of adult health and disease (DOHaD) hypothesis, and consequently increasing awareness of future health risks across various subareas of DOHaD research themes. Understanding how these advanced imaging techniques in animal models and human population studies can be both additively and synergistically used alongside traditional techniques in DOHaD-focussed laboratories is therefore of great interest. Global experts in advanced imaging techniques congregated at the advanced imaging workshop at the 2019 DOHaD World Congress in Melbourne, Australia. This review summarizes the presentations of new imaging modalities and novel applications to DOHaD research and discussions had by DOHaD researchers that are currently utilizing advanced imaging techniques including MRI, hyperpolarized MRI, ultrasound, and synchrotron-based techniques to aid their DOHaD research focus.
Preference and visual cognitive processing demands of alphabetic and QWERTY keyboards of individuals with and without brain injury

ABSTRACT Following a severe brain injury (BI), some literate individuals who require augmentative and alternative communication (AAC) strategies to support communication may benefit from the use of onscreen keyboards to generate text. A range of layouts are available to these individuals within specialized communication software. However, a paucity of information is available to describe user preferences, user perceptions, as well as the visual-cognitive processing demands of such layouts. Such information is critical to guide clinical decision-making for keyboard selection and to provide patient-centered services. This study: (a) described the preferences and perceptions of two onscreen keyboard layouts (QWERTY and alphabetic) and (b) used eye-tracking analysis to investigate the visual-cognitive processing demands between these onscreen keyboards for individuals with and without BI. Results indicated participants in both groups held a strong preference for QWERTY keyboard interfaces and had extensive prior experience using the QWERTY keyboard layout on mobile devices. Eye-tracking analysis revealed less visual-cognitive processing demands using a QWERTY keyboard layout for both groups but were only statistically significant for those without BI. Results suggest that use of a keyboard layout that aligns with client preferences and prior experiences (i.e., the QWERTY keyboard for these participants) may lead to increased satisfaction with the communication experience and increased communication efficiency.
The royal irises ( Iris subg. Iris sect. Oncocyclus ): Plastid and low-copy nuclear data contribute to an understanding of their phylogenetic relationships

Iris sect. Oncocyclus species generally occur in small populations or locally scattered over rocky hillsides, steppes, and deserts from the north Caucasus to the eastern Mediterranean. Species of this section are easily recognized by their inflorescences of a single, large, spherical flower and sepals with a dark signal spot and adjacent beard of multicellular hairs. We present here results of the first phylogenetic study of sect. Oncocyclus based on one low-copy nuclear and six plastid markers from 33 of approximately 42 species and infraspecific taxa. Gene trees are congruent and nuclear markers are more potentially parsimony informative than plastid markers. We identify clades that do not correspond to previously described species groups based on size, color, and shape of perianth parts and show that hypotheses of species monophyly are not supported. In general, diversification is greatest along terminal branches suggesting that species diversified in isolation. The Caucasus is suggested as the ancestral area for sect. Oncocyclus and the eastern Mediterranean as an important area of diversification.
A novel probiotic therapeutic in a murine model of Clostridioides difficile colitis

ABSTRACT Clostridioides difficile infection (CDI) is a common cause of antimicrobial-associated diarrhea. Probiotics have shown variable results in decreasing its incidence and severity. We examined the efficacy of Lactobacillus reuteri administered using a novel probiotic biofilm delivery system in the treatment and prevention of CDI in a murine model. For prophylactic therapy, mice received an oral antibiotic cocktail followed by clindamycin injection, followed by probiotic administration (planktonic vs. biofilm state), followed by C. difficile oral gavage. For treatment therapy, mice received antibiotics and C. difficile first, followed by probiotic administration. Clinical sickness scores (CSS) and intestinal histologic injury scores (HIS) were assigned. In the Prophylactic Therapy model, CSS: 67% of untreated mice exposed to C. difficile demonstrated CSS ≥ 6, which is consistent with C. difficile infection (p< .001 compared to unexposed mice). In mice treated with planktonic Lr, 55% had a CSS ≥ 6, but only 19% of mice treated with Lr in its biofilm state had CSS ≥ 6 (p< .001). Mice receiving Lr + DM-Maltose lost the least amount of weight compared to mice receiving saline (p = .004676) or to mice receiving Lr (p= .003185). HIS: 77% of untreated mice exposed to C. difficile had HIS scores ≥4, which is consistent with C. difficile infection. In mice treated with planktonic Lr, 62% had HIS ≥4, but only 19% of mice treated with Lr in its biofilm state had HIS ≥4. (p< .001). Additionally, mice treated with Lr in its biofilm state had better survival compared to untreated mice and to mice treated with planktonic Lr (p ≤ 0.05). Similar findings for weight loss, CSS, HIS and survival were obtained for Treatment Therapy. A single dose of Lactobacillus reuteri in its biofilm state reduces the severity and incidence of experimental C. difficile infection when administered as both prophylactic and treatment therapy.
Dietary Pattern, Diet Quality, and Dementia: A Systematic Review and Meta-Analysis of Prospective Cohort Studies.

BACKGROUND Diet is an important lifestyle factor that may prevent or slow the onset and progression of neurodegeneration. Some, but not all, recent studies have suggested that adherence to a healthy dietary pattern may be associated with reduced risk of dementia. OBJECTIVE In this meta-analysis, we systematically examined the associations between overall dietary patterns, assessed a priori and a posteriori, and risk of dementia. METHODS We systematically searched PubMed, Web of Science, and the Cumulative Index for Nursing and Allied Health databases from January 1, 1981 to September 11, 2019. Prospective studies published in English were included. Random-effects model was used to calculate the pooled risk ratios and 95% confidence intervals (CIs). RESULTS Sixteen research articles were identified in the systematic review and 12 research articles including 66,930 participants were further included for the meta-analysis. Adherence to high diet quality or a healthy dietary pattern was significantly associated with lower risk of overall dementia (pooled risk ratio = 0.82; 95% CI: 0.70, 0.95; n = 12) and Alzheimer's disease (pooled risk ratio = 0.61; 95% CI: 0.47, 0.79; n = 6) relative to those with low diet quality or an unhealthy dietary pattern. Subgroup analyses stratified by age, sex, follow-up duration, diet quality assessment approach, study location, and study quality generated similar results. CONCLUSION Adherence to a healthy dietary pattern was associated with lower risk of overall dementia. Further randomized controlled trials are needed to provide additional evidence about the role of a healthy diet on the development and progression of dementia.
Synergistic Interface‐Assisted Electrode–Electrolyte Coupling Toward Advanced Charge Storage

Owing to the limited charge storage capability of transitional metal oxides in aqueous electrolytes, the use of redox electrolytes (RE) represents a promising strategy to further increase the energy density of aqueous batteries or pseudocapacitors. The usual coupling of an electrode and an RE possesses weak electrode/RE interaction and weak adsorption of redox moieties on the electrode, resulting in a low capacity contribution and fast self‐discharge. In this work, Fe(CN)64− groups are grafted on the surface of Co3O4 electrode via formation of CoN bonds, creating a synergistic interface between the electrode and the RE. With such an interface, the coupled Co3O4–RE system exhibits greatly enhanced charge storage from both Co3O4 and RE, delivering a large reversible capacity of ≈1000 mC cm−2 together with greatly reduced self‐discharge. The significantly improved electrochemical activity of Co3O4 can be attributed to the tuned work function via charge injection from Fe(CN)64−, while the greatly enhanced adsorption of K3Fe(CN)6 molecules is achieved by the interface induced dipole–dipole interaction on the liquid side. Furthermore, this enhanced electrode–electrolyte coupling is also applicable in the NiO–RE system, demonstrating that the synergistic interface design can be a general strategy to integrate electrode and electrolyte for high‐performance energy storage devices.
Contributions to the Flora of Tropical America: LXXII. Notes on Bignoniaceae: XXVIII: The Identity of Anemopaegma nigrescens

This species was described with doubt in the genus Anemopaegma Mart. ex DC. on account of the colour of the foliage and the dense indumentum of the outer surface of the corolla. I have never seen an authentic specimen or a photograph, and the two syntypes (Sellow 398 and 'L. no. 313') were presumably destroyed at Berlin, in March, 1943. I had quite failed to interpret Schumann's description as suggesting any affinity known to me. Recently, however, the clue to the identity of A. nigrescens was given by J. C. Gomes, Jr., in Arq. Jard. Bot. Rio de Janeiro 12: 150, t. 4 (1953), who transferred the species to Distictella Kuntze on account of the pollen, tendrils and capsule, while his illustration showed a branchlet with foliage, a trifid tendril, foliaceous pseudostipules, flowers and a capsule. Since then, the authorities of the Jardim Botinico at Rio de Janeiro have most generously presented material of three gatherings of D. nigrescens as identified by Dr. Gomes, including duplicates of the two collections (Heringer 1306 and 2764) cited by him in his paper. The identity of this taxon is clear. It agrees in all respects with Pithecoctenium ? stipulare Mart. ex DC. , Prodr. 9: 194; Bur. & K. Schum, l.c. : 171. Gomes's specimens and his plate are an excellent match with Martius 304 in the Munich Herbarium, and also with Pohl 18o6 (K) and Glaziou 8812 (K, P) which I have identified with it. Other specimens of P. stipulare seen by me are Martius 2079 (M), from R. Itahype near Ilheos, Bahia, a collection cited by Bureau and Schumann; St. Hilaire Cat. B2, 2e part. , No. 275 ter (P), correctly identified by Bureau. Returning to Schumann's description of Anemopaegma nigrescens, one immediately sees how close it is to that of Pithecoctenium stipulare, except for minor details of measurement or for the presence or absence of glands on the calyx; and then one notices that Sellow 398, one of the two syntypes of A. nigrescens, is actually cited (and from the same locality in Espiritu Santo) under P. stipulare! Pithecoctenium stipulare belongs to a group of 3 very closely allied species, P. stipulare, P. scabriusculum Mart. ex DC. and P. granulosum (Bur. & K. Schum.) Sprague & Sandwith, which were discussed in Bull. Misc. Inf. Kew
Psychosis‐spectrum experiences linked to specific psychotherapy readiness domains among psychiatrically hospitalized adolescents

Early psychosocial treatment for psychosis‐spectrum symptoms has been linked to positive outcomes, whereas delayed treatment is associated with poorer prognosis. Thus, there is a critical need to bolster psychotherapy engagement efforts, particularly among high‐risk groups and during high‐risk periods, in order to maximize recovery. This study explores the relation between psychosis‐spectrum symptoms and psychotherapy readiness among psychiatrically hospitalized adolescents, a foundational step for developing more effective psychotherapy engagement approaches for this population.