Miracle-dz/UniFAR-FTUs huggingface dataset:
Appropriate Mother Wavelets for Continuous Gait Event Detection Based on Time-Frequency Analysis for Hemiplegic and Healthy Individuals

Gait event detection is a crucial step towards the effective assessment and rehabilitation of motor dysfunctions. Recently, the continuous wavelet transform (CWT) based methods have been increasingly proposed for gait event detection due to their robustness. However, few investigations on determining the appropriate mother wavelet with proper selection criteria have been performed, especially for hemiplegic patients. In this study, the performances of commonly used mother wavelets in detecting gait events were systematically investigated. The acceleration signals from the tibialis anterior muscle of both healthy and hemiplegic subjects were recorded during ground walking and the two core gait events of heel strike (HS) and toe off (TO) were detected from the signal recordings by a CWT algorithm with different mother wavelets. Our results showed that the overall performance of the CWT algorithm in detecting the two gait events was significantly different when using various mother wavelets. By using different wavelet selection criteria, we also found that the accuracy criteria based on time-error minimization and F1-score maximization could provide the appropriate mother wavelet for gait event detection. The findings from this study will provide an insight on the selection of an appropriate mother wavelet for gait event detection and facilitate the development of adequate rehabilitation aids.
Epithelioid Malignant Peripheral Nerve Sheath Tumor (Epithelioid-MPNST) Presenting as Bleeding Rectal Polyp: A Case Report with Systematic Literature Review

Case series Patient: Male, 65 • Female, 47 Final Diagnosis: Epithelioid malignant peripheral nerve sheath tumor Symptoms: Bleeding per rectum Medication: — Clinical Procedure: — Specialty: Pathology Objective: Rare disease Background: Malignant peripheral nerve sheath tumor (MPNST) with pure epithelioid histology MPNST (epithelioid-MPNST) is a distinctly rare variant of MPNST described by World Health Organization. Occurrence of MPNST in the tubular gut is extremely rare with nearly 20 cases reported in the last 40 years. Case Report: In this case report, we described 2 such cases of epithelioid-MPNST occurring in a 65-year male and 47-year-old female, who both presented with bleeding rectal polyps. We also report on our comprehensive systematic literature review. Conclusions: To the best of our knowledge, these are possibly the first two cases of pure epithelioid-MPNST at an unusual site. This needs to be differentiated from lesions more commonly encountered at the related anatomical site, such as malignant melanoma, poorly differentiated carcinoma, lymphoma, or even a gastrointestinal stromal tumor, by appropriate panel of antibodies.
In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery

In the current study, the development of mucoadhesive tablets for buccal delivery of a non-steroidal anti-inflammatory drug was investigated. Binary complexes with piroxicam and cyclodextrins (β-cyclodextrin (β-CD), methylated-β-cyclodextrin (Me-β-CD), and hydroxypropyl-β-cyclodextrin (HP-β-CD)) were prepared by the co-evaporation method. All formulations were characterized by means of differential scanning calorimetry, infrared spectroscopy and powder X-ray diffractometry. Mucoadhesive tablets of binary systems were formulated by direct compression using chitosan as mucoadhesive polymer. The in vitro release profiles of tablets were conducted in simulated saliva and, the drug permeation studies, across porcine buccal mucosa. The results suggest that the rank order effect of cyclodextrins for the drug release was Me-β-CD > HP-β-CD > β-CD, whereas the ex vivo studies showed that the tablets containing chitosan significantly increased the transport of the drug compared to their free complexes. Finally, histological assessment revealed loss of the superficial cell layers, which might be attributed to the presence of cyclodextrins.
Self-Assessment of the Body and Social Competences in the Group of Mothers and Their Adult Daughters

The main research objective of this study was seeking the predictive role of general self-esteem and the body image in social competences among women and their biological daughters. As it stands, there is a lack of research showing the mothers and their adult daughters at the same time in the context of measuring the same psychological variables, i.e., general self-esteem, self-assessment of the body and specific social competences in the scope of behaviour in intimate situations, situations requiring social exposure and assertiveness. The study group comprised 102 individuals; 51 pairs of mothers (40–64 years old, M = 51.33) and their biological daughters (19–25 years old, M = 22.49). The following instruments were used: The Rosenberg Self-esteem Scale, the Contour Drawing Rating Scale, the Body Esteem Scale, the Social Competence Scale, categorized interview (to measure BMI and collect data describing the criteria for selection to the research group). The significance of the differences and the stepwise regression analysis were performed. The results of the study demonstrated the following to be significant predictors of social competences in subjects: General self-esteem B = 0.615, discrepancy real-obligatory body image B = 0.275 among daughters, and physical condition B = 0.362 in mothers. The general self-esteem of daughters positively influences all verified types of their social competences (competences in intimate situations, in case of social exposure and ability to be assertive). However, it is the significant predictor only for mothers’ competences in dealing with situations of social exposure. Discrepancy real-obligatory body image: Seems to be the predictor of daughters’ social competences conditioning effectiveness in situations requiring assertiveness. The physical condition among mothers seems to be especially important for their assertiveness and effectiveness in intimate situations. The conflict between the real and the ideal body image is also an important aspect in predicting the assertiveness in the group of mothers. The study results can prove to be helpful in creating preventive and educational programs focused on self-esteem and social competencies in women, including the context of the relation between mothers and their daughters.
Arabidopsis histone deacetylase HDA15 directly represses plant response to elevated ambient temperature.

Elevated ambient temperatures affect plant growth and substantially impact biomass and crop yield. Recent results indicate that chromatin remodeling is critical in plant thermal responses but implication of histone acetylation enzymes in plant thermal response is not clearly established. Here we show that Arabidopsis histone deacetylase genes HDA9, HDA15, and HDA19 play distinct roles in plant response to elevated ambient temperature. hda9 and hda19 mutants showed a warm temperature-insensitive phenotype at 27°C, whereas hda15 plants displayed a constitutive warm temperature-induced phenotype at 20°C and an enhanced thermal response at 27°C. The hda19 mutation led to upregulation of genes mostly related to stress response at both 20°C and 27°C. The hda15 mutation resulted in upregulation of many warm temperature-responsive as well as metabolic genes at 20°C and 27°C, while hda9 led to differential expression of a large number of genes at 20°C and impaired induction of warm-temperature responsive genes at 27°C. HDA15 is associated with thermosensory mark genes at 20°C and that the association is decreased after shifting to 27°C, indicating that HDA15 is a direct repressor of plant thermal responsive genes at normal temperature. In addition, as hda9, the hda15 mutation also led to up-regulation of many metabolic genes and accumulation of primary metabolites. Furthermore, we show that HDA15 interacts with the transcription factor HFR1 (long Hypocotyl in Far Red1) to cooperatively repress warm-temperature response. Our study demonstrates that the histone deacetylases target to different sets of genes and play distinct roles in plant response to elevated ambient temperature. This article is protected by copyright. All rights reserved.
Increased adaxial stomatal density is associated with greater mesophyll surface area exposed to intercellular air spaces and mesophyll conductance in diverse C4  grasses.

Mesophyll conductance (gm ) is the diffusion of CO2 from intercellular air spaces (IAS) to the first site of carboxylation in the mesophyll cells. In C3 species, gm is influenced by diverse leaf structural and anatomical traits; however, little is known about traits affecting gm in C4 species. To address this knowledge gap, we used online oxygen isotope discrimination measurements to estimate gm and microscopy techniques to measure leaf structural and anatomical traits potentially related to gm in 18 C4 grasses. In this study, gm scaled positively with photosynthesis and intrinsic water-use efficiency (TEi ), but not with stomatal conductance. Also, gm was not determined by a single trait but was positively correlated with adaxial stomatal densities (SDada ), stomatal ratio (SR), mesophyll surface area exposed to IAS (Smes ) and leaf thickness. However, gm did not relate with abaxial stomatal densities (SDaba ) and mesophyll cell wall thickness (TCW ). Our study suggests that greater SDada and SR increased gm by increasing Smes and creating additional parallel pathways for CO2 diffusion inside mesophyll cells. Thus, SDada , SR and Smes are important determinants of C4 -gm and could be the target traits selected or modified for achieving greater gm and TEi in C4 species. This article is protected by copyright. All rights reserved.
The depth and breadth of multiple perceptual asymmetries in right handers and non-right handers

ABSTRACT Several non-verbal perceptual and attentional processes have been linked with specialization of the right cerebral hemisphere. Given that most people have a left hemispheric specialization for language, it is tempting to assume that functions of these two classes of dominance are related. Unfortunately, such models of complementarity are notoriously hard to test. Here we suggest a method which compares frequency of a particular perceptual asymmetry with known frequencies of left hemispheric language dominance in right-handed and non-right handed groups. We illustrate this idea using the greyscales and colourscales tasks, chimeric faces, emotional dichotic listening, and a consonant–vowel dichotic listening task. Results show a substantial “breadth” of leftward bias on the right hemispheric tasks and rightward bias on verbal dichotic listening. Right handers and non-right handers did not differ in terms of proportions of people who were left biased for greyscales/colourscales. Support for reduced typical biases in non-right handers was found for chimeric faces and for CV dichotic listening. Results are discussed in terms of complementary theories of cerebral asymmetries, and how this type of method could be used to create a taxonomy of lateralized functions, each categorized as related to speech and language dominance, or not.
Supporting Pre-Service Teachers' Understanding and Use of Mobile Devices

The use of mobile devices to support learning is increasing in schools and universities. This increase is having an impact on the types of pedagogies that are supporting learning. This chapter explores the use of mobile devices to support pre-service teachers’ professional learning. A constructivist framework is used as a critical lens in conjunction with Howland, Jonassen and Marra’s (2012) ‘meaningful learning’ framework. Additionally, the notions of teacher training about and with mobile learning as described by Baran (2014) are drawn upon to help in understanding the field. The chapter begins with an exploration on-campus learning followed by learning in schools and finally, aspects of on-line learning.
Cognitive Processes Underlying Reading Improvement during a Rhythm-Based Intervention. A Small-Scale Investigation of Italian Children with Dyslexia

Music and rhythm-based training programs to improve reading are a novel approach to treatment of developmental dyslexia and have attracted the attention of trainers and researchers. Experimental studies demonstrating poor basic auditory processing abilities in individuals with dyslexia suggest they should be effective. On this basis, the efficacy of a novel rhythm-based intervention, Rhythmic Reading Training (RRT), was recently investigated and found to improve reading skills in Italian children with dyslexia, but its mode of action remains somewhat unclear. In this study, 19 children and preadolescents with dyslexia received 20 sessions of RRT over 10 weeks. Gains in a set of reading-related cognitive abilities—verbal working memory, auditory, and visual attention, and rhythm processing—were measured, along with reading outcomes. Analysis of the specific contribution of cognitive subprocesses to the primary effect of RRT highlighted that reading speed improvement during the intervention was related to rhythm and auditory discrimination abilities as well as verbal working memory. The relationships among specific reading parameters and the neuropsychological profile of participants are discussed.
The role of chemokines and chemokine receptors in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary artery remodelling leading to increased right ventricular pressure overload, which results in right heart failure and premature death. Inflammation plays a central role in the development of PAH, and the recruitment and function of immune cells are tightly regulated by chemotactic cytokines called chemokines. A number of studies have shown that the development and progression of PAH are associated with the dysregulated expression of several chemokines and chemokine receptors in the pulmonary vasculature. Moreover, some chemokines are differentially regulated in the pressure‐overloaded right ventricle. Recent studies have tested the efficacy of pharmacological agents targeting several chemokines and chemokine receptors for their effects on the development of PAH, suggesting that these receptors could serve as useful therapeutic targets. In this review, we provide recent insights into the role of chemokines and chemokine receptors in PAH and RV remodelling and the opportunities and roadblocks in targeting them.
PATHOGENESIS OF TYPE 2 DIABETES AND INSULIN RESISTANCE ( RM WATANABE , SECTION EDITOR ) What Does Diabetes B Taste ^ Like ?

The T1R2 (taste type 1 receptor, member 2)/T1R3 (taste type 1 receptor, member 3) sweet taste receptor is expressed in taste buds on the tongue, where it allows the detection of energy-rich carbohydrates of food. This single receptor responds to all compounds perceived as sweet by humans, including natural sugars and natural and artificial sweeteners. Importantly, the T1R2/T1R3 sweet taste receptor is also expressed in extra-oral tissues, including the stomach, pancreas, gut, liver, and brain. Although its physiological role remains to be established in numerous organs, T1R2/T1R3 is suspected to be involved in the regulation of metabolic processes, such as sugar sensing, glucose homeostasis, and satiety hormone release. In this review, the physiological role of the sweet taste receptor in taste perception and metabolic regulation is discussed by focusing on dysfunctions leading to diabetes. Current knowledge of T1R2/T1R3 inhibitors making this receptor a promising therapeutic target for the treatment of type 2 diabetes is also summarized and discussed.
Japan-Did economic success breed chronic stagnation ?

This paper contends that there is a continuum in Japan’s experience of growth and decline from the 1990s to the turn of the century and beyond. A lingering attachment to the bureaucratic, financial and political underpinnings of highgrowth success affected Japan’s response to critical shifts in national and international economic circumstance once economic catch-up had been achieved. In the tensions that emerged between shifting circumstance and established practice can be traced the origins and nature of the ‘boom and bust’ years, the lack-lustre reform programme that ensued and the reasons for continued stagnation.
CHARACTERIZATION OF NON-LINEAR THREE-PHASE UNBALANCED CIRCUITS POWERS FLOW SUPPLIED WITH SYMMETRICAL VOLTAGES

The present study continues the research presented in a previous article by the same authors focussed on the power theory of Professor Andrei Ţugulea, dedicated to nonlinear three-phase unbalanced circuits. The defined symmetry, non-symmetry and residual (distorting) active and reactive powers flow and conservation are further investigated in three-phase circuits with neutral. Correspondingly, the original theory introduced the symmetry power factor (SPF), the non-symmetry power factor (NPF) and the distorting power factor (DPF) as suitable quantities for characterizing such three-phase circuits (with or without neutral). The paper proves the validity of the theory extended to three-phase circuits with zero impedance neutral on test-circuits simulated in PSpice software. The resulting data are used in a dedicated software usable in on-line or off-line calculations, as well as on power grid automated management.
FE studies on a coupled energetic-statistical size effect in concrete .

A size effect in concrete elements causes that both the nominal structural strength N and material brittleness decrease with increasing characteristic specimen dimension D. Thus, concrete becomes ductile on a small scale and perfectly brittle on a sufficiently large scale. The reasons of this behaviour are [1]: a) the presence of intense strain localization regions with a certain volume which precede macro-cracks and contribute to a deterministic size effect and b) a random distribution of material properties contributing to a statistical size effect. The first statistical theory introduced by Weibull [2] postulates that a structure is as strong as its weakest component. The statistical size effect by Weibull ignores a spatial correlation between local material properties and a deterministic size effect. Combining the energetic theory with a Weibull statistical theory, a general energetic-statistical theory was developed by Bazant [3].
A COMPUTATION CHAIN IN FLUID-STRUCTURE INTERACTION FOR MARINE APPLICATIONS

Fluid Structure Interaction (FSI) problems are commonly encountered in naval architecture. They can be solved with a monolithic or a partitioned approach [1]. The partitioned approach (or block-iterative method) consists in solving the fluid and the structure problems in a segregated way. Even if this can be done through a single solver, it is most commonly used in a co-simulation context and consequently it is especially well fitted to the resolution of complex FSI problems. Indeed, the co-simulation allows to use complex models for both the fluid and the structure without additional simplifications because each solvers can be numerically adapted to its problem.
Cooccurrence of NDM-1, ESBL, RmtC, AAC(6′)-Ib, and QnrB in Clonally Related Klebsiella pneumoniae Isolates Together with Coexistence of CMY-4 and AAC(6′)-Ib in Enterobacter cloacae Isolates from Saudi Arabia

The aim of this study was to investigate the mechanisms responsible for resistance to antimicrobials in a collection of enterobacterial isolates recovered from two hospitals in Saudi Arabia. A total of six strains isolated from different patients showing high resistance to carbapenems was recovered in 2015 from two different hospitals, with four being Klebsiella pneumoniae and two Enterobacter cloacae. All isolates except one K. pneumoniae were resistant to tigecycline, but only one K. pneumoniae was resistant to colistin. All produced a carbapenemase according to the Carba NP test, and all were positive for the EDTA-disk synergy test for detection of MBL. Using PCR followed by sequencing, the four K. pneumoniae isolates produced the carbapenemase NDM-1, while the two E. cloacae isolates produced the carbapenemase VIM-1. Genotyping analysis by Multilocus Sequence Typing (MLST) showed that three out of the four K. pneumoniae isolates were clonally related. They had been recovered from the same hospital and belonged to Sequence Type (ST) ST152. In contrast, the fourth K. pneumoniae isolate belonged to ST572. Noticeably, the NDM-1-producing K. pneumoniae additionally produced an extended-spectrum ß-lactamase (ESBL) of the CTX-M type, together with OXA-1 and TEM-1. Surprisingly, the three clonally related isolates produced different CTX-M variants, namely, CTX-M-3, CTX-M-57, and CTX-M-82, and coproduced QnrB, which confers quinolone resistance, and the 16S rRNA methylase RmtC, which confers high resistance to all aminoglycosides. The AAC(6′)-Ib acetyltransferase was detected in both K. pneumoniae and E. cloacae. Mating-out assays using Escherichia coli as recipient were successful for all isolates. The blaNDM-1 gene was always identified on a 70-kb plasmid, whereas the blaVIM-1 gene was located on either a 60-kb or a 150-kb plasmid the two E. cloacae isolates, respectively. To the best of our knowledge, this is the first report of the coexistence of an MBL (NDM-1), an ESBL (CTX-M), a 16S rRNA methylase (RmtC), an acetyltransferase (AAC[6′]-Ib), and a quinolone resistance enzyme (QnrB) in K. pneumoniae isolates recovered from different patients during an outbreak in a Saudi Arabian hospital.
FEDERAL UNIVERSITY OF SANTA MARIA TECHNOLOGY CENTER POSTGRADUATE PROGRAM IN PRODUCTION ENGINEERING

MODEL FOR STRATEGIC ANALYSIS OF COMPANY’S PARTNERSHIPS AUTHOR: ADRIANA YOLANDA MORALES GARZA ADVISOR: PROF. DR. ANDREAS DITTMAR WEISE Globalization has caused an increase in market competition; because of this, in the last decades, firms have been looking for different ways to survive and generate high profits. Strategic alliances have become popular among corporations, as a way to reduce costs, gain knowledge, generate more innovative products, obtain different distribution channels, among other advantages. However, these types of organizations are not always successful. There is a lack of models in the literature that can evaluate the performance of partnerships and of each individual company making part of it. Thus, this study aims to develop a new generic model that can evaluate the performance of horizontal and vertical alliances, and also provide information about the business strategy that each different alliance should focus on to improve its performance. The new 3D model is based on two existing models, the Weise Model (2005) and the Petter Model (2012). In order to prove its applicability, it was implemented in two different strategic alliances in Santa Maria, RS, Sonnen Energia and APL Metal Centro. Results from the evaluation of the performance of these two strategic alliances using the 3D Model, provide the users key information to ensure success in their short and long-term goals.