Miracle-dz/UniFAR-FTUs huggingface dataset:
Beyond IT Acceptance

Organizations invest in information technology expecting positive outcomes, but to produce the intended results employees must use the technology. This study applies Adaptive Structuration Theory and Social Construction of Technology frameworks to expand research on the relationship among organizational users and mandatory IT artifacts beyond the initial process of acceptance, which currently constitutes the main paradigm in the IS field. A case study analyzes the mandatory use of an academic portal by lecturers and all the changes that users promote to the artifact and the tasks they perform while using it. Our findings show that if the environment provides flexibility for it, participants refute, adapt replace and complement the artifact that was adopted by the organization, while they appropriate it, in order to improve their efficiency in achieving organizational goals or their own.
Effect of low dose rate ketamine infusions on thermal and mechanical thresholds in conscious cats.

OBJECTIVE To determine the thermal and mechanical antinociceptive effects of two different subanesthetic constant rate infusions of racemic ketamine in cats. STUDY DESIGN Prospective, randomized, blinded, experimental study. ANIMALS Eight healthy adult domestic shorthair cats (two intact females and six neutered males). METHODS The thorax and the lower thoracic limbs of each cat were shaved for thermal (TT) and mechanical threshold (MT) testing and a cephalic catheter was placed. Three intravenous treatments of equivalent volume were given as loading dose (LD) followed by an infusion for 2 hours: (K5) 0.5 mg kg(-1) ketamine followed by 5 μg kg(-1) minute(-1) ketamine infusion, (K23) 0.5 mg kg(-1) ketamine followed by 23 μg kg(-1) minute(-1) ketamine infusion or (S) 0.9% saline solution. Effects on behavior, sedation scores, MT and TT were obtained prior to drug treatment and 0.25, 0.5, 0.75, 1, 1.5, 2, 2.25, 2.5 2.75, 3 hours then every 0.5 hours for 7 hours and 10, 12, 14 and 26 hours after loading dose administration. RESULTS Ketamine induced mild sedation for the period of the infusion, no adverse behavioral effects were observed. Thermal threshold was significantly higher than baseline (K5: 44.5 ± 0.7 °C; K23: 44.5 ± 0.5 °C) at 15 minutes in the K5 group (46.8 ± 3.5 °C) and at 45 minutes in the K23 group (47.1 ± 4.1 °C). In the K23 group TT was significantly increased compared to S and K5 at 45 minutes. In K5 at 15 minutes MT (9.6 ± 4.0 N) was different to baseline (6.1 ± 0.8 N) and to the S group (5.9 ± 2.3 N). CONCLUSION AND CLINICAL RELEVANCE Low dose rate ketamine infusions minimally affect thermal and mechanical antinociception in cats. Further studies with different nociceptive testing methods are necessary to assess whether ketamine could be a useful analgesic in cats.
Measuring Work Disability: What Can Administrative Data Tell Us About Patient Outcomes?

Objective: The purpose of this study was to assess the association between administrative measures of work disability and self-reported work, pain, and functional status. Methods: We conducted baseline and follow-up interviews to assess pain, functional status, work status, and demographic factors in workers with low back injuries, carpal tunnel syndrome, and upper and lower extremity fractures. Administrative measures of work disability were obtained from the Washington State Department of Labor and Industries. Results: Pain intensity and impairment levels were lowest in those who had not received any disability payments, somewhat higher for those who were no longer receiving time loss benefits, and highest for workers receiving time loss payments at the time of interview. Conclusions: Administrative measures of work disability are significantly associated with self-reported outcomes and can be an efficient tool for tracking and evaluating outcomes of medical treatments, surgical procedures, and occupational health programs.
An application of lagrangean decomposition to the resource-constrained minimum weighted arborescence problem

The resource-constrained minimum weighted arborescence problem, a 0-1 integer programming model with application in hierarchical distribution network design, is introduced. Since the model is NP-hard, an enumeration method is required to solve it to optimality. Lagrangean decomposition, a special form of Lagrangean relaxation, is applied to the model. Both analytically and empirically, Lagrangean decomposition is shown to improve on bounds obtained by a conventional Lagrangean relaxation. An enumeration algorithm, that embeds a specialized Lagrangean dual ascent scheme to solve a Lagrangean decomposition dual, is designed, and problems with up to 1000 0-1 variables are solved.
Simulation estimation of two‐tiered dynamic panel Tobit models with an application to the labor supply of married women

In this paper a computationally practical simulation estimator is proposed for the two-tiered dynamic panel Tobit model originally developed by Cragg (1971). The log-likelihood function simulated through procedures based on a recursive algorithm formulated by the Geweke–Hajivassiliou–Keane simulator is maximized. The simulation estimators are then applied to study the labor supply of married women. The rich dynamic structure of the labor force participation decision as well as hours worked decisions that are conditional on the participation of married women are identified by using the proposed simulation estimators. The average partial effects of the participation and hours worked decisions for married women in response to fertility decisions and increases in the husband's income are also investigated. It is found that the hypothesis that the fertility decision is exogenous and the hypothesis that the husband's income is exogenous to married women's labor supply function are both rejected in the dynamic and static two-tiered models. Moreover, children aged between 6 and 13 years old may have a negative impact on the hours worked decision for married women that is conditional on their participation. However, these children may provide some positive incentives for married women to participate in the labor force. Copyright © 2009 John Wiley & Sons, Ltd.
Mitotic Phosphorylation Prevents the Binding of HMGN Proteins to Chromatin

ABSTRACT Condensation of the chromatin fiber and transcriptional inhibition during mitosis is associated with the redistribution of many DNA- and chromatin-binding proteins, including members of the high-mobility-group N (HMGN) family. Here we study the mechanism governing the organization of HMGN proteins in mitosis. Using site-specific antibodies and quantitative gel analysis with proteins extracted from synchronized HeLa cells, we demonstrate that, during mitosis, the conserved serine residues in the nucleosomal binding domain (NBD) of this protein family are highly and specifically phosphorylated. Nucleosome mobility shift assays with both in vitro-phosphorylated proteins and with point mutants bearing negative charges in the NBD demonstrate that the negative charge abolishes the ability of the proteins to bind to nucleosomes. Fluorescence loss of photobleaching demonstrates that, in living cells, the negative charge in the NBD increases the intranuclear mobility of the protein and significantly decreases the relative time that it is bound to chromatin. Expression of wild-type and mutant proteins inHmgN1−/− cells indicates that the negatively charged protein is not bound to chromosomes. We conclude that during mitosis the NBD of HMGN proteins is highly phosphorylated and that this modification regulates the interaction of the proteins with chromatin.
Ideales de maternidad en las revistas de familia. Análisis de 'Mi bebé y yo', 'Ser padres', y 'El mundo de tu bebé'

Resumen: se analiza el discurso que las revistas de familia tienen sobre la maternidad y la crianza a partir del modelo de ‘maternidad intensiva’ propuesto por Hays (1998). En concreto, hemos tomado como muestra los números publicados en junio y octubre de 2011 de ‘Mi bebé y yo’, ‘Ser padres. La revista del bebé y la familia’, y ‘El mundo de tu bebé’ por tratarse de publicaciones dedicadas al bebé y la familia de mayor consumo en España. A partir de los resultados obtenidos se ofrece una reflexión sobre este ideal de perfección maternal y el peso emocional que representa en la mujer-madre.
Principles of Situation Research: Towards a Better Understanding of Psychological Situations

There is currently no consensus on how to study psychological situations, and situation research is still riddled with problems of conceptualization (what is a situation and what is it not? ) and measurement (how can situational information be assessed? ). This target article formulates three core principles (with corollaries) to provide a foundation for psychological situation research: the Processing, Reality and Circularity Principles. These principles build upon each other, ranging from basic to more complex issues (e.g. how to study situations in both objective and subjective terms). They are intended to guide and spur more coherent research programs that produce cumulative knowledge on psychological situations. We conclude with a plea for real–life, multi–method, multi–situation, multi–time, multi–group designs that can illuminate the interwoven dynamics between persons (with their personalities and behaviour) and situations. Copyright © 2015 European Association of Personality Psychology
Clozapine versus "high-dose" olanzapine in refractory early-onset schizophrenia: an open-label extension study.

OBJECTIVE A recent 12-week controlled comparison demonstrated the superiority of clozapine to "high-dose" olanzapine in adolescents with treatment-refractory schizophrenia. In the present study, the authors conducted a 12-week, open-label, follow-up study to examine changes in lipid and glucose metabolism in youths maintained on clozapine and to determine whether patients who were previously randomized to high-dose olanzapine (up to 30 mg/day) responded to clozapine. METHOD Thirty three (14 clozapine, 19 olanzapine) (85%) of 39 patients were available for the present 12-week, open-label extension study. Extended safety data using an intention-to-treat analysis from the 14 subjects treated with clozapine for a total of 24 weeks are presented. In addition, we report the clinical outcomes for 10 of 19 olanzapine-treated patients who were switched after 12 weeks to clozapine due to treatment nonresponse. Clinical response was defined as a decrease of 30% or more in total Brief Psychiatric Rating score from week 12 and a Clinical Global Impression-Improvement rating of 1 (very much improved) or 2 (much improved). RESULTS The incidence of hypertriglyceridemia (defined as fasting triglycerides >125 mg/dL) (10/14 = 71%) and the incidence of "prediabetes" (defined as fasting blood glucose > or =100) (4/14 = 29%) at week 24 in the clozapine-treated subjects were notable. Seven (70%) of 10 of young patients with schizophrenia who failed treatment with "high-dose" olanzapine were found to respond to a 12-week, open-label clozapine trial. CONCLUSIONS Clinicians and caregivers need to be aware of potential metabolic adverse events of long-term clozapine treatment. Adolescents with a poor response to olanzapine may do better on clozapine.
Hand movement span after mild traumatic brain injury: A longitudinal study

This study examined whether memory span was impaired during the acute and post-acute phases following mild traumatic brain injury (mTBI). Twenty-two adults with mTBI were compared with 22 controls on computerized tasks of immediate memory for verbal, spatial, and hand movement sequences under no interference (baseline) and articulatory suppression conditions. Groups were assessed within a month and followed up 3–12 months post-injury. In the acute phase, there were no group differences across tasks under either condition. At follow-up, all spatial and verbal span scores and associated practice effects were equivalent across groups. Yet for the hand movement task, baseline movement span was worse for the mTBI group suggesting that they failed to benefit from practice to the same extent as controls. Furthermore, the fact that this group difference in span scores disappeared when articulatory suppression was imposed indicates that successful hand movement task performance involves verbal recoding. (JINS, 2006, 12, 580–584.)
Remotely-Operated Vehicle applications in port and harbor site characterization: Payloads, platforms, sensors, and operations

Remotely-Operated Vehicles (ROVs) serve many functions during site characterization surveys including dive team assistance, quality control, and anomaly reacquisition. Reacquisition applications require detection, geo-registration, and investigation of items of interest located on, or below, the seafloor. Underwater target detection using ROVs poses many challenges. Detection sensors must be mounted far enough away from the vehicle to reduce noise effects from thrusters and other vehicle sensors. Conversely, detection sensors must be mounted close enough to the vehicle to maintain vehicle maneuverability. Vehicle noise characterization with respect to sensor standoff and orientation is discussed. ROV applications require the collection of correlated detection sensor data along with global position information. Positional accuracy varies depending on the method used and can be dependent on site and deployment conditions. Positioning systems, including Ultra-Short Base Line (USBL), Doppler Velocity Logs (DVL), and Real-time Kinematic Global Positioning System (RTK-GPS) are discussed with respect to underwater object localization. We present the development of underwater metal detection systems consisting of magnetometer and electromagnetic induction (EMI) sensors mounted on a mini-ROV. Detection sensors include fluxgate magnetometers and a diver handheld EMI sensor modified for data transmission through the ROV umbilical for digital data capture and audio data delivery topside. Sensor sensitivities are defined through analysis of data collected against targets of various sizes. We discuss the development, performance, and operation of various payloads for different applications and compare ROV and dive team results and efficiency.
CHRONIC MYELOGENOUS LEUKAEMIA

In the last decade, improvements in both non-transplant and transplant therapy have extended the lives of patients with CML, particularly those in chronic phase. The future will probably bring a greater understanding of molecular leukaemogenesis and options for treating CML. Non-transplant therapies in development include novel agents and combination therapy. Transplant strategies seek to decrease regimen-related toxicity and directly manipulate the immune system to eradicate disease. Clinical and laboratory science seems poised to add novel therapies to the armamentarium against CML. It is exciting to contemplate what reviews of CML written 10 years from now will discuss.
Long-term trial of bosentan monotherapy for pulmonary arterial hypertension in Japanese patients

ABSTRACT Objective: To determine the efficacy and safety of long-term bosentan monotherapy in Japanese patients with pulmonary arterial hypertension (PAH). Research design and methods: The present study was an extension to a 12‑week open-label trial of bosentan in which 21 Japanese patients with PAH received bosentan, 125 mg twice daily. Of the 21 patients in the initial trial, 20 elected to participate in the long-term study and to continue to receive bosentan for up to 3 years. Main outcome measures: The primary efficacy measure was comparison of World Health Organization (WHO) functional class for pulmonary arterial hypertension following long-term (> 2.5 years) therapy compared with baseline (prior to initiation of bosentan). Secondary outcomes included time from initiation of bosentan therapy to clinical worsening and safety assessments. Results: Bosentan treatment was continued for a median of 2.7 years (range 0.4–3.0 years); 12 patients received bosentan monotherapy for at least 2.5 years. Following long-term treatment, improvement of WHO functional class compared with baseline was observed in 9/12 patients (75.0%) and in 3/12 patients (25.0%) the functional class remained stable; no patient experienced a worsening of WHO functional class compared with baseline. Overall, long-term treatment with bosentan was well tolerated. Conclusions: Long-term treatment with bosentan is well tolerated and is associated with sustained clinical improvement in Japanese patients with PAH. Bosentan, therefore, represents a valuable treatment option for Japanese patients with this devastating disease.
Sustainable Competitive Advantage for Educational Institutions: A Suggested Model.

This paper outlines a model of the factors that are critical to the establishment and maintenance of sustainable competitive advantage for education services enterprises in international markets. It draws together theories of competitive advantage developed by industrial economics and management theory, with literature relating to services marketing. In examining a theory of sustainable competitive advantage for services exports, the paper discusses the concepts involved and presents a model of the process involved in achieving it. The model seeks to explain the strategic decision making environment in which the education exporter operates, and the outcome ideal to achieving a competitive advantage.
Characterization of murine monoclonal antibodies directed against the core proteins of human immunodeficiency virus types 1 and 2

Monoclonal antibodies (MAbs) raised against the core proteins of human immunodeficiency virus type 1 (HIV-1; laboratory strain HTLV-IIIB) and HIV-2 (strain ROD) were investigated in a variety of tests, e.g., enzyme-linked immunosorbent assay (ELISA), immunostaining of Western immunoblots, immunofluorescence, immunoprecipitation, and alkaline phosphatase anti-alkaline phosphatase assay. The MAbs were grouped according to their cross-reactions. Seven HIV-1-specific MAbs reacted exclusively with HIV-1, and five showed cross-reactivity with HIV-2 and simian immunodeficiency virus of macaques in ELISA. Four of the 15 MAbs against HIV-2 reacted only with the HIV-2 protein p26. Six showed cross-reactivity with HIV-1, and five showed a broad reaction with all three viruses. Overlapping 30-amino-acid-long peptides derived from the p24 protein sequence of HIV-1 were used in an epitope-mapping system. Three different immunogenic regions (A, B, and C) could be defined. Specific regions where anti-HIV-1 and -HIV-2 MAbs cross-reacted were mapped with shorter oligopeptides.
Two mirror‐image sensory maps with domain organization in the mouse main olfactory bulb

The glomerular sheet in the olfactory bulb (OB) provides an olfactory sensory map identifying which odorant receptors (ORs) in the nose are activated by inhaled odorants. How are the glomeruli spatially arranged in the OB? Using OCAM and neuropilin-1 (NP1) as molecular markers for target glomeruli of distinct subsets of olfactory axons, we demonstrate here that glomeruli are parceled into topographically distinct domains. Spatial arrangement of these domains suggests that each OB contains two mirror-image maps of the glomeruli. In situ hybridization shows that the glomeruli representing the same OR are symmetrically arranged; one in a domain in the lateral hemisphere and the other in a corresponding domain in the medial hemisphere of the OB. These results suggest that OB contains two symmetrical OR maps with similar domain organization.
A generative Bézier curve model for surf-zone tracking in coastal image sequences

This work introduces a generative Bézier curve model suitable for surf-zone curve tracking in coastal image sequences. The model combines an adaptive curve parametrised by control points governed by local random walks with a global sinusoidal motion model. This allows for changing wave-break conditions and tides to be tracked using a bootstrap particle filter. Results obtained on a sequence of images show that wave-break locations can be tracked through a wide variety of challenging weather and lighting conditions. In addition, the paper shows how wave buoy measurements can be used as forcing dynamics in place of the sinusoidal tide component of the proposed model to improve results.
Severe hypoglycemia and hyperinsulinemia in falciparum malaria.

We studied the occurrence, clinical manifestations, and mechanism of hypoglycemia in patients with falciparum malaria in eastern Thailand. Hypoglycemia, which was often severe and recurrent, occurred in 17 patients, including 12 in a series of 151 patients with cerebral malaria. Thirty episodes were investigated. Plasma concentrations of insulin and C peptide were inappropriately high, and lactate and alanine concentrations were significantly higher than in patients with falciparum malaria who were normoglycemic (P less than 0.05). Sixteen patients had received quinine; plasma quinine and insulin concentrations were correlated at the time of hypoglycemia (P = 0.007). In seven healthy fasting volunteers intravenous quinine increased the mean plasma insulin concentration (+/- S.D.) from 8.9 +/- 3.1 to 17.1 +/- 8.4 mU per liter (P = 0.02) and reduced the mean plasma glucose concentration from 88 +/- 20 to 68 +/- 23 mg per deciliter (P = 0.002). Our observations indicate that in falciparum malaria quinine-induced insulin secretion may precipitate hypoglycemia, but other factors, including the large glucose requirements of the malaria parasites may also contribute. This important complication, associated with pregnancy and severe disease, must be excluded in all patients with falciparum malaria who have impaired or deteriorating consciousness.
Akilli Uzmanlasmaya Yönelik Bölgesel Arastirma Ve Yenilik Stratejisi Hazirlama Kilavuzu

Akilli uzmanlasma stratejisi belirli faaliyetlerde arastirma ve yenilige dayali bir uzmanlasmayla bolgenin (kendi kaynaklarina dayali) ekonomik donusumunu hedefleyen bir stratejidir. Diger bir ifadeyle, uzun donemde bolge ekonomisini daha rekabetci ve daha surdurulebilir bir ekonomiye donusturme stratejisidir. Bu strateji daha onceki bolgesel kalkinma stratejilerinin basarisizliklari uzerine ortaya cikmistir. Bu calisma TRB2 bolgesinde akilli uzmanlasma stratejisinin olusturulmasi icin bir kilavuz sunmayi amaclamaktadir.
Application of Genome-Wide Expression Analysis To Identify Molecular Markers Useful in Monitoring Industrial Fermentations

ABSTRACT Genome-wide expression analysis of an industrial strain of Saccharomyces cerevisiae identified the YOR387c and YGL258w homologues as highly inducible in zinc-depleted conditions. Induction was specific for zinc deficiency and was dependent on Zap1p. The results indicate that these sequences may be valuable molecular markers for detecting zinc deficiency in industrial fermentations.
Response of mice connective tissue to intracanal dressings containing chlorhexidine

Substances containing chlorhexidine (CHX) have been studied as intracanal medicaments. The aim of the present study was to characterize the response of mouse subcutaneous connective tissue to CHX‐containing medications by conventional optical microscopy. The tissue response was evaluated by implanting polyethylene tubes containing one of the substances evaluated: Calen paste + 0.5% CHX, Calen + 2% CHX, 2% CHX gel, and Calen paste (control). After experimental periods of 7, 21, and 63 days, the implants (n = 10) were removed along with the subcutaneous connective tissue. Tissue samples were subjected to histological processing, and sections were stained with hematoxylin and eosin. Qualitative and quantitative analyses of the number of inflammatory cells, blood vessels, and vascularized areas were performed. Results were analyzed by ANOVA and Tukey tests with the significance level set at 5%. We concluded that Calen + 0.5% CHX led to reparative tissue response in contrast with Calen + 2% CHX and 2% CHX gel, which induced persistent inflammatory response, pointing to the aggressive nature of this mixture. When Calen + 2% CHX and 2% CHX gel were compared, the latter induced more intense inflammatory response. Microsc. Res. Tech., 2012. © 2012 Wiley Periodicals, Inc.