Miracle-dz/UniFAR-FTUs huggingface dataset:
Sera of patients with celiac disease and neurologic disorders evoke a mitochondrial-dependent apoptosis in vitro.

BACKGROUND & AIMS The mechanisms underlying neurologic impairment in celiac disease remain unknown. We tested whether antineuronal antibody-positive sera of patients with celiac disease evoke neurodegeneration via apoptosis in vitro. METHODS SH-Sy5Y cells were exposed to crude sera, isolated immunoglobulin (Ig) G and IgG-depleted sera of patients with and without celiac disease with and without neurologic disorders, and antineuronal antibodies. Adsorption studies with gliadin and tissue transglutaminase (tTG) were performed in celiac disease sera. Apoptosis activated caspase-3, apaf-1, Bax, cytochrome c, cleaved caspase-8 and caspase-9 and mitochondrial respiratory chain complexes were evaluated with different methods. RESULTS SH-Sy5Y cells exposed to antineuronal antibody-positive sera and isolated IgG from the same sera exhibited a greater percentage of TUNEL-positive nuclei than that of antineuronal antibody-negative sera. Neuroblasts exposed to antineuronal antibody-negative celiac disease sera also showed greater TUNEL positivity and apaf-1 immunolabeled cells than controls. Antigliadin- and anti-tTG-depleted celiac disease sera had an apoptotic effect similar to controls. Anti-caspase-3 immunostained cells were greater than controls when exposed to positive sera. The mitochondrial respiratory chain complex was reduced by positive sera. Western blot demonstrated only caspase-9 cleavage in positive sera. Cytochrome c and Bax showed reciprocal translocation (from mitochondria to cytoplasm and vice versa) after treatment with positive sera. CONCLUSIONS Antineuronal antibodies and, to a lower extent, combined antigliadin and anti-tTG antibodies in celiac disease sera contribute to neurologic impairment via apoptosis. Apaf-1 activation with Bax and cytochrome c translocation suggest a mitochondrial-dependent apoptosis.
Promotion of atomic hydrogen recombination as an alternative to electron trapping for the role of metals in the photocatalytic production of H2

Significance The use of catalysis assisted by light is a promising route to convert solar energy into chemical fuels such as H2. Photon absorption promotes electrons in semiconductor catalysts from the valence to the conduction band of those solids, and the excited electrons may be used to reduce protons in water to produce hydrogen gas. Unfortunately, those electrons tend to rapidly return to their ground state instead. The addition of metals has been shown to enhance photocatalytic activity, and that has been explained by their ability to trap the excited electrons and quench the electron–hole recombination process that neutralizes the photoexcitation. Here we challenge the validity of this model and provide an alternative explanation for the enhancement. A new thinking about this mechanism may result in new searches for appropriate cocatalysts. The production of hydrogen from water with semiconductor photocatalysts can be promoted by adding small amounts of metals to their surfaces. The resulting enhancement in photocatalytic activity is commonly attributed to a fast transfer of the excited electrons generated by photon absorption from the semiconductor to the metal, a step that prevents deexcitation back to the ground electronic state. Here we provide experimental evidence that suggests an alternative pathway that does not involve electron transfer to the metal but requires it to act as a catalyst for the recombination of the hydrogen atoms made via the reduction of protons on the surface of the semiconductor instead.
[Predictors of Turnover among New Nurses using Multilevel Survival Analysis].

PURPOSE The purpose of this study was to examine factors influencing new graduate nurse turnover. METHODS This study was carried out as a secondary analysis of data from the 2010 Graduates Occupational Mobility Survey (GOMS). A total of 323 nurses were selected for analysis concerning reasons for turnover. Data were analyzed using descriptive statistics and multilevel survival analysis. RESULTS About 24.5% of new nurses left their first job within 1 year of starting their jobs. Significant predictors of turnover among new nurse were job status, monthly income, job satisfaction, the number of hospitals in region, and the number of nurses per 100 beds. CONCLUSION New graduate nurses are vulnerable to turnover. In order to achieve the best health of the nation, policy approaches and further studies regarding reducing new graduate nurse turnover are needed.
Motivations for Pleasure

Crompton, John L. , "Motivations for Pleasure Vacations," Annals of Tourism Research, October/December 1979, VI(4):408-424. The study is concerned with identifying those motives of pleasure vacationers which influence the selection of a destination. It also seeks to develop a conceptual framework capable of encompassing such motives. Empirically nine motives were identified. Seven were classified as socio-psychological, namely: escape from a perceived mundane environment, exploration and evaluation of self, relaxation, prestige, regression, enhancement of kinship relationships, and facilitation of social interaction. The two remaining motives, novelty and education, formed the alternate cultural category. The latter were noted to be at least partially aroused by the particular qualities that a destination offered. By contrast sociopsychological motives were found to be unrelated to destination attributes. Here the emphasis shifted from the destination itself to its function as a medium through which socio-psychological needs could be satisfied. The research data suggest that the tourist industry may usefully pay greater attention to socio-psychological motives in developing product and promotion strategies.
Kallikreins and kininogens in saliva and plasma of patients presenting with rheumatoid arthritis

We evaluated the activities of salivary kallikrein and tissue/plasma kallikreins, and the plasma levels of high-molecular (HKg) and low-molecular (LKg) weight kininogens in patients with rheumatoid arthritis. The patients exhibited higher levels of the active salivary kallikrein compared to the controls. In contrast, the total salivary kallikrein activity of patients was not different from controls. In plasma from the patients, tissue kallikrein activity or plasma prekallikrein activity was not significantly different from the controls. Plasma HKg levels observed in patients were higher than in controls, whereas plasma LKg levels did not differ significantly from controls. Our results showed that most of the salivary kallikrein seen in patients is in its active form, suggesting the presence of systemic or local factors with the ability to activate salivary pro-kallikrein.
Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment: the surgery and stimulation

Background: There have been several reports of successful deep brain stimulation (DBS) for the treatment of severe Gilles de la Tourette syndrome (GTS). Method: 18 cases of GTS who were resistant to at least 6 months of standard and innovative treatments, as well as to psychobehavioural techniques, underwent DBS. DBS was placed bilaterally in the centromedian–parafascicular (CM–Pfc) and ventralis oralis complex of the thalamus. Patients were evaluated after surgery, with immediate and formal assessments at least every 3 months, including “on–off” and “sham off” in the first nine patients. Results: All patients responded well to DBS, although to differing degrees. The duration of follow-up assessments ranged from 3 to 18 months. The comorbid symptoms of obsessive–compulsive behaviour, obsessive–compulsive disorder, self-injurious behaviours, anxiety and premonitory sensations decreased after treatment with DBS. There were no serious permanent adverse effects. Conclusions: DBS is a useful and safe treatment for severe GTS. The results of ours and previous DBS reports suggest that the CM–Pfc and ventralis oralis complex of the thalamus may be a good DBS target for GTS.
Current Share in Multiphase DC–DC Converters Using Digital Filtering Techniques

This paper introduces a new method of passive current balancing for digital control of multiphase DC-DC converters based upon the duty-cycle-matching principle. Current balance is achieved by inserting a digital filter into the control path. The method does not rely on a current balancing loop, and therefore, the stability and performance concerns associated with the traditional current balance loop are obviated. Being sensorless, it is insensitive to current measurement inaccuracies caused by noise, component value tolerance, or variation. It will be shown that effective current balancing can be achieved via some simple modifications to standard voltage-mode control laws, allowing current balancing to be achieved with minor additional complexity. The effectiveness of the method has been demonstrated by experimental validation of a multiphase DC-DC converter. The current share scheme has been shown to perform well dynamically, matching currents cycle by cycle during load steps, and clearly benefiting from the absence of the slow current share loop popular in traditional methods. The proposed current share filter blends well with existing digital controllers. Given the very low complexity in implementing the filter, the degree of matching achieved is exceptional.
Silicon Carbide Power Transistors: A New Era in Power Electronics Is Initiated

During recent years, silicon carbide (SiC) power electronics has gone from being a promising future technology to being a potent alternative to state-of-the-art silicon (Si) technology in high-efficiency, highfrequency, and high-temperature applications. The reasons for this are that SiC power electronics may have higher voltage ratings, lower voltage drops, higher maximum temperatures, and higher thermal conductivities. It is now a fact that several manufacturers are capable of developing and processing high-quality transistors at cost that permit introduction of new products in application areas where the benefits of the SiC technology can provide significant system advantages.
Gastric Cancer: Extent of Lymph Node Dissection and Requirements for a Correct Staging

Aims and Background Lymphatic spread is an important prognostic factor in gastric cancer. The TNM classification requires at least 15 lymph nodes to stage and identify three prognostic groups according to the number of metastatic lymph nodes: N1 (1-6), N2 (7-15), N3 (>15). The aim of this study was to investigate which type of lymph node dissection allows an accurate staging. Methods From 1996 to 2001, we treated 140 gastric cancer patients, 27 with D1 and 113 with D2 dissection. We evaluated lymph node count, status and ratio between metastatic and total number of excised lymph nodes, keeping 20% as the cutoff value. Results The mean number of lymph nodes was 18 and 33 respectively for D1 and D2 (P <0.001), 41% of patients in D1 and 5% in D2 had less than 15 lymph nodes (P <0.001). 59% in D1 and 73% in D2 (P = 0.145) had lymph node metastases, but this incidence decreased to 36% (P = 0.045) and 16% (P <0.001) respectively for D, and D2 when less than 15 lymph nodes were available. Considering the ratio between metastatic and total number of lymph nodes, 45% of D1 versus 3% of D2 (P <0.001) in the N1 group exceeded 20%. Conclusions D2 lymph node dissection is better than D1 in providing at least 15 lymph nodes required for a correct staging. We confirm the risk of a downstage when less than 15 lymph nodes are available.
Awareness and perceptions of climate change among extension workers of Agricultural Development Programme (ADP) in Anambra State, Nigeria

The study sought to ascertain awareness and differences in male and female extension workers perceptions of climate change. The study was carried out in Anambra state, Nigeria. A total of forty respondents (20 males and 20 females) purposively selected from four agricultural zones in the state were used for the study. Data were analysed using percentage, mean score and t- test. All( 100%) of males and 95% of the females were married. Majority (71.3%) of the males were in the age range of 45 to 54 years while majority(77.9%) of the females were in the age range of 40 – 49years. The mean ages were 45 years and 44 years for the male and female extension workers respectively. Majority of the male (60%) and female workers (68.5%) had HND/ degree certificate and had about 4 to 6 persons in the household. Females noticed and heard about climate change earlier than their male colleagues. Male extension workers sourced information on climate change mainly from radio (100%), newspaper (95%) and television (80%) while the female extension workers sourced mainly from radio (90%), fellow extension workers (85%) and friends/relations (70%). There were significant differences in their perception of swamp rice production (t= 2.4, p≤ 0.05), overgrazing of farmlands by livestock (t =- 2.7, p≤ 0.05) and high use of irrigation (t = - 2.2, p≤ 0.05) as causes of climate change. There were also significant differences in their perception of high humidity (t = 2.7, p≤ 0.05) as indicator of climate change and high incidence of weeds (t= -2.7, p≤ 0.05) as effect of climate change . Females perceived these factors more as causes, indicator and effects of climate change than males. The study emphasized on the need to educate/train both male and female extension workers generally on issues concerning climate change and specifically on the causes, indicators and effects of climate change that they are ignorant of. This is for onward transmission to their clientele, enhanced agricultural productivity and encouraging future.
Fretting Analysis of Connector Terminals

As the number of circuits used in automobiles increases, larger force is required to mate connectors. The larger insertion force necessitates the use of an assembling robot, otherwise increasing the cost due to complicated structure of connectors. In order to reduce the cost, connectors with low insertion force are required. This may cause an increase in the fretting failure in electric contacts of terminals. The authors have developed a computational model based on cellular automata to simulate the contact failure. This model can calculate both the behavior of moving particles and chemical reactions simultaneously, which is difficult by the conventional FEM model. In experiments, the fretting probability depends on the contact pressure, slip distance, and surface conditions. The dependence of electric contact resistance on the slip cycle is calculated by this method. When the contact pressure is very high or the slip distance is very small, fretting is absent. The effects of contact materials and the thickness of plated metals are evaluated. The calculated electric contact resistance profiles of the electric contacts agree well with the experimental results.
Impact of Sanitary and Phytosanitary Measures and Technical Barriers on International Trade

In principle, sanitary and phytosanitary (SPS) measures aim to protect the health of humans, plants and animals, while technical barriers to trade (TBT) ensure product quality and safety. However, governments may overshoot the requirements of health and consumer safety and use SPS and TBT to shield domestic producers from fair competition. Potential abuses of both measures as protectionist tools not only constrain international trade but also consumers’ welfare by restricting the choices of goods available to them. Our analysis shows that in general the measures seem to be positive for trade after controlling for other factors. However, the impacts are mainly driven by exports from advanced economies. Less developed countries do not gain as much when implementing the measures or are disadvantaged in exporting goods, particularly when importers are advanced economies. Within South countries, developing Asia are more adversely affected by SPS while non-Asian developing country exports are afflicted more by TBT. SPS in particular is damaging intraregional agricultural trade among Asian countries, which calls for policy makers to act more proactively in resolving nontariff hurdles in the region.
Some disassembly required: role of DNA translocases in the disruption of recombination intermediates and dead-end complexes.

References http://www.genesdev. org/cgi/content/full/20/18/2479#References This article cites 65 articles, 28 of which can be accessed free at: service Email alerting click here top right corner of the article or Receive free email alerts when new articles cite this article sign up in the box at the Topic collections (35 articles) DNA Replication, Recombination, and Repair  Articles on similar topics can be found in the following collections
Społeczna ewolucja rynku finansowego. CSR i IR - wybrane aspekty

Streszczenie: Dynamiczne przemiany spoleczno-kulturowe zmuszają instytucje rynku finansowego do podjecia dzialan mających na celu pozyskanie spolecznej akceptacji dla wlasnej dzialalności. Umiejetnośc dostosowania sie do spolecznych wymagan bedzie niemal warunkowala dalsze funkcjonowanie biznesu. Celem artykulu jest wskazanie na jedno z kluczowych wyzwan, jakim jest funkcjonowanie instytucji rynku finansowego wobec rosnących wymagan spolecznych, oraz zwrocenie uwagi na rozwiązania systemowe przydatne dla efektywnego wsparcia spolecznej ewolucji rynku finansowego. Za takie uznano koncepcje: CSR (Corporate Social Responsibility) oraz IR (Investor Relations). Wykorzystano nastepujące metody badawcze: krytyczna analiza literatury przedmiotu, studium przypadku, metoda opisowa, metoda porownawcza. W artykule wskazano na praktyczne oraz krytyczne aspekty tematu, co pozwolilo na identyfikacje ograniczen w stosowaniu obu rozwiązan oraz na sformulowanie wnioskow.
Identifying and prioritising critical success factors for CRM implementation: a case study

By considering literature review of key articles published during 2004-2011, the present study provided a comprehensive list of 24 success and failure factors of customer relationship management (CRM) projects. Then, the best classification of factors is chosen in literature of CRM through studying a variety of general classification which makes these factors easier to study and prioritise. Analytical hierarchy process (AHP) has been applied for prioritising of these factors based on the experts' judgment in a case study due to proposed hierarchical structure and diversity of success and failure factors. According to experts' opinion, the factors 'official support of the project by top managers' and 'power of management in focusing on customers and adopting performance programme' are the most important success and failure factors in CRM projects, respectively. The factors laid in general factor of 'internal and external users' have the lowest priority.
Graft versus myeloma may overcome the unfavorable effect of deletion of chromosome 13 in multiple myeloma.

Partial or complete deletion of chromosome 13 (del13) is considered one of the most important prognostic factors for multiple myeloma (MM). [1-4][1] The impact of del13 on the outcome of allogeneic stem cell transplantation is unknown. We describe 2 patients with unfavorable MM who benefited from a
Modest weight loss does not decrease cardiovascular morbidity and mortality in adults with type 2 diabetes

Commentary on: Wing RR, Bolin P, Brancati FL, et al. Look AHEAD Research Group. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med 2013;369:145–54. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Diet, physical activity and weight loss are recommended in the management of type 2 diabetes. This recommendation is largely based on short-term intervention studies which show improvements in cardiovascular risk factors including glycaemic control, lipids, blood pressure and inflammation. The Look AHEAD (Action for Health in Diabetes) randomised controlled trial (RCT) studied the impact of long-term weight loss through an intensive lifestyle intervention on cardiovascular morbidity and mortality in type 2 diabetes. Look AHEAD is a multicentre, RCT. A total of 5145 adults aged 45–75 years with type 2 diabetes were randomised to receive either an intensive lifestyle intervention (n=2570) or control (n=2575). The intervention … [1]: {openurl}? query=rft.jtitle%253DN%2BEngl%2BJ%2BMed%26rft.issn%253D0028-4793%26rft.volume%253D369%26rft.spage%253D145%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa1212914%26rft_id%253Dinfo%253Apmid%252F23796131%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref? access_num=10.1056/NEJMoa1212914&link_type=DOI [3]: /lookup/external-ref? access_num=23796131&link_type=MED&atom=%2Febmed%2F19%2F2%2F64.atom [4]: /lookup/external-ref? access_num=000321567300010&link_type=ISI
Occupational heat illness in Washington State, 1995-2005.

BACKGROUND Little information exists describing the incidence of heat-related illness (HRI) among non-military working populations. An analysis of HRI cases utilizing workers' compensation data has not been previously reported. METHODS We used both ICD-9 and ANSI Z16.2 codes with subsequent medical record review to identify accepted Washington State Fund workers' compensation claims for HRI over the 11-year time period from 1995-2005. RESULTS There were 480 Washington workers' compensation claims for HRI during the 11-year study period. NAICS industries with the highest workers' compensation HRI average annual claims incidence rate were Fire Protection 80.8/100,000 FTE, Roofing Construction 59.0/100,000 FTE, and Highway, Bridge and Street Construction 44.8/100,000 FTE. HRI claims were associated with high outdoor ambient temperatures. Medical risk factors for HRI were present in some cases. CONCLUSIONS HRI cases occur in employed populations. HRI rates vary by industry and are comparable to those previously published for the mining industry.
Improving real estate broker service quality via TOPSIS and AHP

Service quality is usually a critical concern for most service industry firms. The need for high-quality service has always been an important issue for many organizations. A real estate brokerage is one of service industry. Its duty in representing a buyer is to identify and present properties possessing qualities and characteristics sought by a buyer. To a buyer, he will consider so many different criteria due to its impact on the product when he decides to buy a real estate or not. And some of these multiple criteria decision-making (MCDM) attempt to have conflicting decision objectives. An evaluation model is constructed to rank the priorities of the real estate properties by a broker using TOPSIS and AHP. It can be helpful to the real estate broker when he wants to locate multiple candidates whose attributes closely match the requirements of a buyer for the purpose of promoting a mutually agreeable match. This approach should increase the level of satisfaction among clients. A numerical example is also presented to illustrate the proposed working of the model.