Miracle-dz/UniFAR-FTUs huggingface dataset:
OncoCL-KB, a Knowledgebase for Integration of Clinical and Molecular Cancer Data

OncoCL-KB is a knowledgebase built on OncoCL, our ontology for describing cancer cell types. OncoCL provides a semantic framework for integrating cancer-associated molecular data, and the properties imparted by the corresponding disrupted cellular pathways, with conventional pathology data associated with cancer progression. OncoCL makes use of a number of other mature biomedical and clinical ontologies. In particular, OncoCL builds upon the cell type ontology (CL) to define a canonical cell that then undergoes oncogenic change and tumorigenesis with the acquisition of the cancer hallmarks as described by Hanahan and Weinberg. OncoCL-KB embeds annotated data sets – including cancerassociated genes and genomic variants, cancer-associated pathways, cancer stem cell markers, and cancer mouse models – in the OncoCL semantic framework. OncoCL-KB provides a resource that can contribute to a better understanding of cancer predisposition, earlier diagnosis, and better therapies. This work is supported by NIH with funding through NCI CA155825.
FACTORS INFLUENCING INNOVATION MANAGEMENT PRACTICES IN NIGERIA TEXTILE MANUFACTURING FIRM ’ S

Globally, innovation & innovation management (IM) are becoming a common phenomenon for firms to be able to compete and become successful. Despite many studies that have been conducted on IM, research track have shown that factors that influence IM activities are limited which has brought about series of problems associated IM. Notable among them are increasing and constant fear for change, fear of failure, poor working culture, limited resources and unclear goals for execution etc. this study uses a behavioral approach to investigate the factors that could influence textile firms IM practices in Nigeria. A quantitative approach was employed to obtain data from selected textile firms in Nigeria. Using random sampling technique, 154 firms were selected to respond to the survey questionnaire. The study findings based on the results of exploratory factor analysis (EFA) and multiple regression analysis show that factors play an important role influencing IM of the firm. The findings further illustrate how factors can enhance the competitiveness and success of firms within Nigeria industrial landscape. Based on these findings, the study concludes that more emphasis and insights to be placed on factors that have positive impact on firms sustainability and growth in other to boast productivity. Finally, it is suggested that more future research be carried out to explore IM in-depth and in different
Elektri£ki aktivni defekti uvedeni ionskom implantacijom u SiC

Ionskom implantacijom iona He energije 2MeV u razli£itim dozama, u Schottky diode od 4H silicij karbida n-tipa uneseni su defekti u kristalnoj strukturi. Iz mjerenja kapacitivno-naponske karakteristike Schottky dioda primijetili smo smanjenje koncentracije slobodnih nosioca naboja na dubini pri kojoj je ionskom implantacijom najvi2e o2te¢ena kristalna struktura. Tehnikom tranzijentne spektroskopije dubokih nivoa promatrani su duboki nivoi koji odgovaraju unesenim elektri£ki aktivnim defektima te odreene su energije i udarni presjeci za uhvat elektrona dvaju primije¢enih dubokih nivoa. Prvi duboki nivo nismo identi cirali s nekim ve¢ opaoenim dubokim nivom, dok drugi duboki nivo odgovara Z1/2 nivou koji potje£e od vakancije ugljika.
Bluetongue: new insights and lessons learnt

Chris Oura assesses northern Europe's recent experiences of bluetongue and considers the situation as things stand I REMEMBER very well that hot day back in the summer of 2006 when a phone call came through to me from a colleague in the Netherlands saying that they would like to send us samples from some sheep that they had tested positive for bluetongue virus (BTV). We had known for some time that BTV strains had been steadily moving northwards into southern Europe; however, this massive jump as far north as the Netherlands really took us by surprise. To this day we still do not know where this virus came from, and more importantly, the route it took. Not knowing how it arrived makes it impossible to plug the entry route and stop the same thing happening again. The strain of BTV (BTV serotype 8) that came into northern Europe rapidly proved itself to be a truly unique and nasty virus. The first unwelcome surprise was the severity of clinical signs seen in cattle and the second highly significant finding was that this virus was able to cross the placenta and infect calves/lambs in utero. This strain of BTV, depending of the stage of gestation that infection had occurred, was causing abortions, the birth of brain-damaged calves and the birth of normal …
The Effect of Nepheline Syenite Addition on the Sintering Behaviour of Sanitaryware Bodies

In this study, the effect of nepheline syenite addition on the sintering and material properties of sanitaryware porcelain bodies was investigated. Three ceramic sanitaryware bodies were prepared by substituting Na feldspar (max. 30 wt %) with nepheline syenite. The sintering behaviour was evaluated using an optical dilatometer. Samples were sintered at 1300 °C using step-by-step processing. In addition the linear shrinkage, water absorption and bending strength were measured. Results showed that the addition of nepheline syenite enhanced the material properties of sanitaryware bodies, had a positive effect on the formation of the liquid phase during sintering and improved overall the sintering and mechanical properties.
Differential regulation of the lateral mobility of plasma membrane phospholipids by the extracellular matrix and cholesterol

In this study, we compared qualitative and quantitative changes in the lateral mobility of phospholipid molecules in the plasma membrane of intact cells under various conditions of specific interaction of integrins in the cell membrane with two extracellular matrix (ECM) components viz. fibronectin (FN) and laminin (LN). We found a strong and specific correlation between the lower lateral mobility of phosphatidylcholine (PC) and higher lateral mobility of phosphatidylethanolamine (PE) when cells were expressing high levels of α5β1 integrin and thus were adherent and motile on FN. The interaction between PC and FN in α5 integrin expressing cells was aided by the strong affinity of α5 integrin to the FN matrix. Cholesterol was involved in regulating the lateral mobility of PC to a great extent and of PE to a lesser extent without affecting the overall microviscosity of the plasma membrane or the distribution of caveolin‐marked domains. The distribution and mobility of PC and PE molecules in the lamellipodial regions differed from that in the rest of the membrane and also in the more motile and in the less motile cells. We propose that these differences in distribution of PC and PE in different regions of cell membrane and their respective lateral mobility are observed due to the specific interaction of PC molecules with FN molecules in the ECM. Our results outline a new role of integrin–matrix interactions in the regulation of membrane phospholipid behavior. J. Cell. Physiol. 215: 550–561, 2008. © 2007 Wiley‐Liss, Inc.
Network ( STAR ) Conference , Honiara , Solomon Islands , 2006 Managing non living resources in the Pacific through economics

While development of natural non living resources such as minerals and water can better the lives of Pacific islanders, it needs to be managed to ensure a safe and healthy environment. And as any resource manager today knows, to manage resources we need to manage the people who use them. A number of projects in the Pacific have recently turned to economic tools to help manage the way people use non living natural resources. In this paper selected case studies will be used to:  demonstrate the different ways that economic tools are helping to improve the governance of a variety of non living natural resources in the Pacific; and  consider the prospects for using these tools more generally in the Pacific in the future. To highlight the ways in which economic tools can improve the governance of non living natural resources, a simple project cycle is used. A number of case studies including the following are used to show how economic tools are improving management of non living natural resources in different sectors including water, disasters, oceans,, minerals and energy. Details of case studies are provided in the paper accompanying the presentation. Following discussion of the case studies, the implications for using economic analysis to support the management of non living resources in the Pacific is discussed.
[Screening for mild cognitive impairment: usefulness of the 7-Minute Screen Test].

INTRODUCTION The <<7- Minute Screen>> is a neurocognitive screening test for the detection of Alzheimer's disease (AD) patients in primary care settings. It consists of 4 brief subtests (orientation, memory, visuoconstruction and verbal fluency) and provides a broader neuropsychological profile than other widely used screening tests, The aim of the present study was to study the usefulness of this screening test for the detection of Mild Cognitive Impairment (MCI). METHODS Thirty-two patients with probable AD (NINCDS-ADRDA criteria), 25 patients with MCI, and 35 healthy control subjects, matched for age and education, underwent a comprehensive neuropsychological battery and the Rio-de-la-Plata version of the 7-Minute Screen. RESULTS. This test showed 93 % sensitivity and 97% specificity in detecting mild-moderate Alzheimer's disease MMSE<24), but it exhibited a substantially decreased sensitivity (28 %) in its ability to detect MCI in AD (MMSE >2 4 ). CONCLUSION The screening batteries do not replace a m o re compre h e n s i ve neuro psychological assessment. Th ey are useful in detecting patients with mild dementia, but caution must be the rule when considering a diagnosis of MCI.
Ecosystem size predicts social-ecological dynamics

Recreational fisheries are complex adaptive systems that are inherently difficult to manage because of heterogeneous user groups (consumptive vs. nonconsumptive) that use patchily distributed resources on the landscape (lakes, rivers, coastlines). There is a need to identify which system components can effectively predict and be used to manage nonlinear and cross-scale dynamics within these systems. We examine how ecosystem size or water body size can be used to explain complicated and elusive angler-resource dynamics in recreational fisheries. Water body size determined angler behavior among 48 Nebraska, U.S.A. water bodies during an 11year study. Angler behavior was often unique and nonlinear across water body sizes. For example, anglers spent more time fishing and harvested more fish at larger water bodies compared to smaller water bodies. Time fished increased across smaller water bodies, but reached a threshold at larger water bodies. The number of fish released increased as a function of water body size across smaller water bodies and then plateaued. Subtle changes in water body size caused abrupt changes in angler behavior, that is, water body size structures angler-resource dynamics in recreational fisheries. We believe that including water body size, a simple and easily measured metric, in fisheries management will increase effectiveness of cross-scale actions and minimize unintended consequences for recreational fisheries. Applying uniform management actions, e.g., harvest regulations, across small and large water bodies may elicit contrasting anglerresource responses. Water body size may also be useful for understanding angler typologies. Based on our findings, we expect that ecosystem size is a prominent and valuable system component that will determine and explain coupled user-resource dynamics in other complex adaptive systems.
Highlip The : : I---Vm " l I-I lv Pathfinder L . L-IIl , 8-Km Land Data Set

Introduction The Goddard Space Flight Center's (GSFC) Distributed Active Archive Center (DAAC) has generated a global, long-term (19811994) remotely sensed land data set, using measurements from the fivechannel, Advanced Very High Resolution Radiometer (AVHRR) instrument (Kidwell, 1991) flown on the NOAA -7 , -9 and -11 afternoon orbit satellites. Products from this data set are available free-ofcharge to the public and are provided in a variety of formats at spatial resdlutions of 8-km and l o x l o . Generation of this Pathfinder AVHRR Land (PAL) data set is a joint NOAA and NASA activity; NOAA is responsible for providing the raw AVHRR 4-km Global Area Coverage (GAC) data and NASA is responsible for processing, qualitv checking, archiving, and distributing the data sct products (James and Kalluri, 1994). A Land Science Working Group (LSWG) of scientists, chaired by Dr. J . R. G. Townshend of the Department of Geography, University of Maryland, defined the algorithnls and validation procedures for the of the data set.
Rat Strain and Vendor Differences in Collateral Anastomoses

Recently we observed inter- and intrastrain differences in cortical infarct volumes after middle cerebral artery (MCA) occlusion. Variations in the anastomoses providing collateral blood supply could account for different lesion sizes. Our objectives were to compare number and internal diameters of the MCA-anterior cerebral artery (MCA-ACA) anastomoses and to determine if the lesion extended beyond branches of the MCA territory into the field of the ACA in the rat strains/lines. Sprague-Dawley rats and Wistar rats from Simonsen Laboratories (SLSD and SLWIS) and Sprague-Dawley rats from Taconic Laboratories (TLSD) and Charles River Laboratories (CRSD) were anesthetized and injected with papaverine and Vultex (white latex) for arterial visualization. Some rats were also subjected to MCA occlusion. Significantly fewer anastomoses were present in SLSD and SLWIS than in CRSD and TLSD (p < 0.05). The mean internal diameters of the anastomoses were not significantly different between the strains/lines (p > 0.05). After MCA occlusion, significantly more (p < 0.05) TLSD and CRSD than SLSD had lesions extending from the MCA field beneath the anastomoses and into the region supplied by the ACA. Neither the number, luminal diameter, nor density of MCA-ACA anastomoses appears to be the limiting factor that differentiates lesion size following MCA occlusion in these particular rat strains/lines. Therefore, factors other than anatomical variations probably account for different lesion sizes.
Financial Integration in Europea Cointegration Analysis of European Stock Markets

This thesis has studied short and long-term dependence structures between European stock markets. Johansen's test for cointegration and Granger's test for non-causality have been applied in order to measure the degree of financial integration in Europe. The cointegration analysis has employed a comparative perspective in which different countries with different institutional adaptation to the economic cooperation within Europe have been considered. The study finds strong support for the existence of cointegration between the Belgian, Norwegian, Swiss and British stock markets in the period after the launch of the euro. This result indicates that financial integration has increased in Europe since no cointegration was identified prior to the introduction of the euro. However, it is more difficult to determine to what extent the European financial cooperation has affected the degree of integration because of the difficulties with isolating formal treaties contribution to the stationary equilibrium. Both the EU and the euro's importance may have affected the integration process, but this thesis finds that this is not the only explanation. Thus, it is more likely that the liberalization of financial markets and the overall integration process best explain the increase in financial integration. The most significant finding is that the cointegrated stock markets in the long-term can be regarded as a regional financial market characterized by similar systematic risk factors. This has implications for both policy-makers who adjust existing policies in Europe and investors looking to allocate portfolios in an efficient manner.
Steady and unsteady non-Newtonian inelastic flows in a planar T-junction q

0142-727X/$ see front matter 2012 Elsevier Inc. A http://dx.doi. org/10.1016/j.ijheatfluidflow. 2012.11. 00 q Research Units: UMTP (Covilhã) and CEFT (Porto) ⇑ Corresponding author. E-mail addresses: heldermiguelmm@hotmail.com (P.J. Oliveira). Steady and unsteady laminar flows in a planar 2D T-junction, having a dividing or bifurcating flow arrangement (one main channel with a side branch at 90 ), are studied numerically for non-Newtonian inelastic fluids whose rheological characteristics are similar to those of blood. These computational fluid dynamics simulations explore a wide range of variation of inertia (through the Reynolds number, Re), flow rate ratio (proportion of extracted to inlet flow rates, b) and shear thinning (the power-law index of the model, n), and investigate their influence on the sizes and intensities of the recirculating eddies formed near the bifurcation, and on the resulting distribution of the shear stress fields. Such flow characteristics are relevant to hemodynamics, being related to the genesis and development of vascular diseases, like the formation of atherosclerotic plaques and thrombi near arterial bifurcations. To represent the decay of viscosity with shear rate we apply the Carreau-Yasuda equation, one of the most utilized Generalized Newtonian Fluid model in blood simulations. In many comparisons of the present parametric study it was require that the level of inertia was kept approximately the same when n was varied. This implied a consistent definition of Re with the viscosity calculated at a representative shear rate. 2012 Elsevier Inc. All rights reserved.
Regional Tree Regularization for Interpretability in Black Box Models

The lack of interpretability remains a barrier to the adoption of deep neural networks. Recently, tree regularization has been proposed to encourage deep neural networks to resemble compact, axis-aligned decision trees without significant compromises in accuracy. However, it may be unreasonable to expect that a single tree can predict well across all possible inputs. In this work, we propose regional tree regularization, which encourages a deep model to be well-approximated by several separate decision trees specific to predefined regions of the input space. Practitioners can define regions based on domain knowledge of contexts where different decision-making logic is needed. Across many datasets, our approach delivers more accurate predictions than simply training separate decision trees for each region, while producing simpler explanations than other neural net regularization schemes without sacrificing predictive power. Two healthcare case studies in critical care and HIV demonstrate how experts can improve understanding of deep models via our approach.
Proinflammatory role of fractalkine (CX3CL1) in rheumatoid arthritis.

OBJECTIVE Fractalkine (CX3CL1) represents the sole member of the so-called CX3C chemokines. In rheumatoid arthritis (RA), functional studies suggest a role for this chemokine in monocyte chemotaxis and angiogenesis in the rheumatoid synovium. We analyzed the expression of fractalkine within different T cell subsets of the peripheral blood and expression of its receptor CX3CR1 within the rheumatoid synovium to further characterize its pathogenic role in RA. METHODS Peripheral blood mononuclear cells (PBMC) were isolated from 17 patients with RA and analyzed by flow cytometry in comparison to healthy blood donors. To identify the T helper cell cytokine profile of fractalkine-expressing cells, flow cytometric analysis of PBMC was performed after stimulation with PMA and ionomycin. Expression of fractalkine and its receptor was characterized in RA synovium by immunohistochemistry and laser capture microdissection microscopy. RESULTS Flow cytometric analysis of fractalkine-expressing T cell subsets revealed a low proportion of fractalkine-expressing CD4+ and CD8+ T cells in both RA patients and controls. In addition, fractalkine was predominantly expressed in CD4+ T cells with a Th1-type cytokine expression profile. In RA synovium, fractalkine was detected in synovial macrophages, dendritic cells, endothelial cells, and a small proportion of T cells. The fractalkine receptor CX3CR1 was found in synovial macrophages, dendritic cells, and T cells as well as in synovial fibroblasts. Fractalkine stimulation of cultured synovial fibroblasts resulted in a marked upregulation of matrix metalloproteinase-2 (MMP-2) production. CONCLUSION The results suggest that fractalkine may represent a Th1-type chemokine. Upregulation of MMP-2 production in synovial fibroblasts upon fractalkine stimulation in vitro supports the hypothesis of a proinflammatory role of this chemokine in RA.
Behavior of the Minimum Euclidean Distance Optimization Precoders with Soft Maximum Likelihood Detector for High Data Rate MIMO Transmission

The linear closed loop Multiple-input Multiple-output (CL-MIMO) precoding techniques characterized by the channel state information knowledge (CSI), at both sides of the link, aims to improve information throughput and reduce the bit error rate in the communication system. The processing involves multiplying a signal by a precoding matrix, computing from the CSI with some optimized criteria. In this paper, we proposed a new concatenation of the precoders optimizing the minimal Euclidean distance with soft Maximum Likelihood (soft-ML) detection. We analyze the performance in terms of bit error rate (BER) for the proposed association with the three well-known quantized precoders: Maximum of minimum Euclidean distance (Max-dmin) precoder, Orthogonalized Spatial Multiplexing precoder (POSM), and Orthogonalized Spatial Multiplexing (OSM) based on the same criteria, in coded MIMO system over a Rayleigh fading channel, using Quadrature Amplitude Modulation (QAM). Simulations show the interest of the proposed association of the dmin-based precoder with a soft - Ml detector, and the best result is achieved for Max-dmin precoder.
Maximum Energy Harvesting Control Foroscillating Energy Harvesting Systems 2007

This thesis presents an optimal method of designing and controlling an oscillating energy harvesting system. Many new and emerging energy harvesting systems, such as the energy harvesting backpack and ocean wave energy harvesting, capture energy normally expelled through mechanical interactions. Often the nature of the system indicates slow system time constants and unsteady AC voltages. This paper reveals a method for achieving maximum energy harvesting from such sources with fast determination of the optimal operating condition. An energy harvesting backpack, which captures energy from the interaction between the user and the spring decoupled load, is presented in this paper. The new control strategy, maximum energy harvesting control (MEHC), is developed and applied to the energy harvesting backpack system to evaluate the improvement of the MEHC over the basic maximum power point tracking algorithm. 1 This work was partially funded by The Office of Naval Research under STTR Phase I contract #N00014-06-M-0308