Miracle-dz/UniFAR-FTUs huggingface dataset:
Subacute Myopericarditis Without Myocardial Infarction Treated With Intravenous Immunoglobulin in a Child With Marked Elevation of Plasma Cardiac Troponin I.

e report the case of an 11-year-old W boy who came to our emergency room in January 2016 with oppressive retrosternal pain worsened by breathing acts. He never had other similar episodes in the past, although he had experienced asthma and gastroesophageal reflux disease. His family history was negative for any heart disease. On admission, his complete blood count and biochemical analysis were normal, including electrolytes. We noted highly increased myocardial fraction of creatine phosphokinase and cardiac troponin I (cTnI) in the serum, 108.2 ng/mL (normal value < 7.0) and 31.985 ng/mL (normal value < 0.040), respectively. The C-reactive protein level was also raised (133.8 mg/L, normal value < 5). The electrocardiogram findings showed ST segment elevation and globally normal voltage. The serum cTnI level was still raised after 6 hours, requiring the child's admission in the pediatric intensive care unit where his hemodynamics and vital parameters remained stable overall. Heart ultrasound investigation showed a normal function of the left ventricle (LV)with normal ejection fraction (approximately 70%). Amyopericarditiswas suspected, and therapy started with indomethacin, bisoprolol, and enalapril. A serologic test for adenovirus, cytomegalovirus, Epstein-Barr virus, coxsackievirus, echovirus, and Mycoplasma pneumoniae did not reveal any acute infection. A polymerase chain reaction of blood samples for the detection of viral genomeswas negative. However, during the following hours, precordial chest pain seemed to worsen and serum cTnI increased to 34.207 ng/mL, suggesting the start of treatment with 2 cycles of intravenous immunoglobulin (IVIG), each one at a dose of 1 g/kg. These were administered on days 2 and 3 of hospital stay without any adverse effect. Indomethacin, bisoprolol, and enalapril were
Understanding views on everyday use of personal health information: Insights from community dwelling older adults

ABSTRACT Background: Older adults apply various strategies to pursue healthy aging, but we know little about their views and use of personal health information to accomplish those ends. Methods: As a first step in formulating the role of personal health information management (PHIM) in healthy aging, we explored the perspectives of older adults on health and health information used in their everyday lives through four focus groups with 25 community-dwelling adults aged 60 and over. Results: We found that the concept of wellness–the holistic and multidimensional nature of health and wellbeing–plays prominently in how older adults think about health and health information. Participants expressed wellness from a position of personal strength, rather than health-related deficits, by focusing on wellness activities for staying healthy through: (1) personal health practices, (2) social network support, and (3) residential community engagement. Conclusion: Although these themes involve personal health information, existing PHIM systems that focus on disease management are generally not designed to support wellness activities. Substantial opportunity exists to fill this wellness support gap with innovative health information technology designed for older adults. Findings carry implications for the design of PHIM tools that support healthy aging and methods for engaging older adults as co-producers of this critical support.
Combinatorial techniques for enhancing neuroprotection

Brain and spinal cord (CNS) trauma typically kill a number of neurons, but even more neurons are killed by secondary causes triggered by the initial trauma. Thus, a minor insult may rapidly cause the death of a vastly larger number of neurons and complete paralysis. The best mechanism for reducing the extent of neurological deficits is to minimize the number of neurons killed by post‐trauma sequelae. Neuroprotection techniques take many diverse forms with a breadth too great for a short review. Therefore, this review focuses on the neuroprotection provided by hypothermia and a number of other neuroprotective techniques, when administered singly or in combination, because it is generally found that combinations of applications lead to significantly better neuroprotection than is achieved by any one alone. The combinatorial approach to neuroprotection holds great promise for enhancing the degree of neuroprotection following trauma, leading to maximum maintenance of neurological function.
On generalised and specialised spatial information grids: are geo-services ready?

Abstract After the set-up of a spatial data infrastructure (SDI) and a national information infrastructure (NII) in many countries, the provision of geo-services became one of the most important and attractive tasks. With the integration of global positioning system (GPS), geographic information system (GIS) and remote sensing (RS), we can, in principle, answer any geo-spatial related question: when and where what object has which changes? An intelligent geo-service agent could provide end-users with the most necessary information in the shortest time and at the lowest cost. Unfortunately there is still a long way to go to achieve such goals. The central component in such geo-services is the integration of the spatial information system with a computing grid via wire- and wireless communication networks. This paper will mainly discuss the grid technology and its integration with spatial information technology, expounding potential problems and possible resolutions. A novel categorising of information grids in the context of geo-spatial information is proposed: generalised and specialised spatial information grids.
The AGC protein kinase UNICORN controls planar growth by attenuating PDK1 in Arabidopsis thaliana

Tissue morphogenesis critically depends on the coordination of cellular growth patterns. In plants, many organs consist of clonally distinct cell layers, such as the epidermis, whose cells undergo divisions that are oriented along the plane of the layer. The developmental control of such planar growth is poorly understood. We have previously identified the Arabidopsis AGCVIII-class protein kinase UNICORN (UCN) as a central regulator of this process. Plants lacking UCN activity show spontaneous formation of ectopic multicellular protrusions in integuments and malformed petals indicating that UCN suppresses uncontrolled growth in those tissues. In the current model UCN regulates planar growth of integuments in part by directly repressing the putative transcription factor ABERRANT TESTA SHAPE (ATS). Here we report on the identification of 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) as a novel factor involved in UCN-mediated growth control. PDK1 constitutes a basic component of signaling mediated by AGC protein kinases throughout eukaryotes. Arabidopsis PDK1 is implied in stress responses and growth promotion. Here we show that loss-of-function mutations in PDK1 suppress aberrant growth in integuments and petals of ucn mutants. Additional genetic, in vitro, and cell biological data support the view that UCN functions by repressing PDK1. Furthermore, our data indicate that PDK1 is indirectly required for deregulated growth caused by ATS overexpression. Our findings support a model proposing that UCN suppresses ectopic growth in integuments through two independent processes: the attenuation of the protein kinase PDK1 in the cytoplasm and the repression of the transcription factor ATS in the nucleus. Author Summary Plant organs, such as petals or roots, are composites of distinct cell layers. As a rule, cells making up a layer, for example the epidermis, the outermost layer of a tissue, divide “within the plane” of the layer. This cellular behavior results in the two-dimensional sheet-like or planar growth of the cell layer. The mechanism orchestrating such a growth pattern is poorly understood. In particular, it is unclear how uncontrolled and “out-of-plane” growth is avoided. Here we provide insight into this process. Our data indicate that higher than normal activity of a central regulator of growth and stress responses results in wavy and malformed petals and in protrusion-like aberrant outgrowths in the tissue that will develop into the seed coat. It is therefore important to keep this factor in check to allow proper formation of those tissues. We further show that a protein called UNICORN attenuates the activity of this regulator thereby ensuring the sheet-like growth of young petals or the developing seed coat.
Health Care Professionals’ Perceptions of Home Telemonitoring in Heart Failure Care: Cross-Sectional Survey

Background Noninvasive telemonitoring (TM) can be used in heart failure (HF) patients to perform early detection of decompensation at home, prevent unnecessary health care utilization, and decrease health care costs. However, the evidence is not sufficient to be part of HF guidelines for follow-up care, and we have no knowledge of how TM is used in the Nordic Baltic region. Objective The aim of this study was to describe health care professionals’ (HCPs) perception of and presumed experience with noninvasive TM in daily HF patient care, perspectives of the relevance of and reasons for applying noninvasive TM, and barriers to the use of noninvasive TM. Methods A cross-sectional survey was performed between September and December 2016 in Norway and Lithuania with physicians and nurses treating HF patients at either a hospital ward or an outpatient clinic. A total of 784 questionnaires were sent nationwide by postal mail to 107 hospitals. The questionnaire consisted of 43 items with close- and open-ended questions. In Norway, the response rate was 68.7% (226/329), with 57 of 60 hospitals participating, whereas the response rate was 68.1% (310/455) in Lithuania, with 41 of 47 hospitals participating. Responses to the closed questions were analyzed using descriptive statistics, and the open-ended questions were analyzed using summative content analysis. Results This study showed that noninvasive TM is not part of the current daily clinical practice in Norway or Lithuania. A minority of HCPs responded to be familiar with noninvasive TM in HF care in Norway (48/226, 21.2%) and Lithuania (64/310, 20.6%). Approximately half of the HCPs in both countries perceived noninvasive TM to be relevant in follow-up of HF patients in Norway (131/226, 58.0%) and Lithuania (172/310, 55.5%). For physicians in both countries and nurses in Norway, the 3 most mentioned reasons for introducing noninvasive TM were to improve self-care, to reduce hospitalizations, and to provide high-quality care, whereas the Lithuanian nurses described ability to treat more patients and to reduce their workload as reasons for introducing noninvasive TM. The main barriers to implement noninvasive TM were lack of funding from health care authorities or the Territorial Patient Fund. Moreover, HCPs perceive that HF patients themselves could represent barriers because of their physical or mental condition in addition to a lack of internet access. Conclusions HCPs in Norway and Lithuania are currently nonusers of TM in daily HF care. However, they perceive a future with TM to improve the quality of care for HF patients. Financial barriers and HF patients’ condition may have an impact on the use of TM, whereas sufficient funding from health care authorities and improved knowledge may encourage the more widespread use of TM in the Nordic Baltic region and beyond.
Site‐specific analysis of N‐glycans on haptoglobin in sera of patients with pancreatic cancer: A novel approach for the development of tumor markers

It was found in our previous studies that the concentration of fucosylated haptoglobin had increased in the sera of patients with pancreatic cancer (PC) compared to those of other types of cancer and normal controls. Haptoglobin, an acute phase protein, has four potential N‐glycosylation sites, although it remains unknown which site is responsible for the change in fucosylated N‐glycans. In the present study, site‐specific N‐glycan structures of haptoglobin in sera obtained from patients with PC or chronic pancreatitis (CP) were analyzed using liquid chromatography‐electrospray ionization mass spectrometry. Mass spectrometry analyses demonstrated that concentrations of total fucosylated di‐, tri‐ and tetra‐branched glycans of haptoglobin increased in the sera of PC patients. Tri‐antennary N‐glycans containing a Lewis X‐type fucose markedly increased at the Asn211 site of haptoglobin N‐glycans. While fucosylated N‐glycans derived from serum haptoglobin of patients with CP slightly increased, di‐fucosylated tetra‐antennary N‐glycans were observed only at this site in PC patients, and were absent in the haptoglobin of normal controls and individuals with CP. Thus, the present study provides evidence that site‐specific analyses of N‐glycans may be useful as novel tumor markers for PC. © 2008 Wiley‐Liss, Inc.
The Internet-of-Things: Reflections on the past, present and future from a user-centered and smart environment perspective

This paper introduces the Internet-of-Things (IoT) and describes its evolution from a concept proposed by Kevin Ashton in 1999 through its public emergence in 2005 in a United Nations ITU report entitled “The Internet of Things”, to the present day where IoT devices are available as off-the-shelf products from major manufacturers. Using a systematic study of public literature, the paper presents a five-phase categorisation of the development of the Internet-of-Things from its beginnings to the present day. Four mini case studies are included to illustrate some of the issues involved. Finally, the paper discusses some of the big issues facing future developers and marketers of Internet-of-Things based products ranging from artificial intelligence (AI) through to customer privacy and acceptance finishing with an optimistic assessment of the future of the Internet-of-Things.
Dec-MCTS: Decentralized planning for multi-robot active perception

We propose a decentralized variant of Monte Carlo tree search (MCTS) that is suitable for a variety of tasks in multi-robot active perception. Our algorithm allows each robot to optimize its own actions by maintaining a probability distribution over plans in the joint-action space. Robots periodically communicate a compressed form of their search trees, which are used to update the joint distribution using a distributed optimization approach inspired by variational methods. Our method admits any objective function defined over robot action sequences, assumes intermittent communication, is anytime, and is suitable for online replanning. Our algorithm features a new MCTS tree expansion policy that is designed for our planning scenario. We extend the theoretical analysis of standard MCTS to provide guarantees for convergence rates to the optimal payoff sequence. We evaluate the performance of our method for generalized team orienteering and online active object recognition using real data, and show that it compares favorably to centralized MCTS even with severely degraded communication. These examples demonstrate the suitability of our algorithm for real-world active perception with multiple robots.
Shaping digital earth applications through open innovation – setting the scene for a digital earth living lab

Science and policy increasingly request for sustainable development and growth. Similarly, Digital Earth undergoes a paradigm shift to an open platform that actively supports user engagement. While the public becomes able to contribute new content, we recognize a gap in user-driven validation, feedback and requirements capture, and innovative application development. Rather than defining Digital Earth applications top down, we see a need for methods and tools that will help building applications bottom up and driven by community needs. These should include a technology toolbox of geospatial and environmental enablers, which allow to access functional building blocks and content in multiple ways, but – equally important – enable the collaboration within partially unknown stakeholder networks. The validation and testing in real-life scenarios will be a central requirement when approaching the Digital Earth 2020 goals, which were articulated recently. We particularly argue to follow a Living Lab approach for co-creation and awareness rising in relation to environmental and geospatial matters. We explain why and how such a Digital Earth Living Lab could lead to a sustainable approach for developing, deploying, and using Digital Earth applications and suggest a paradigm shift for Virtual Globes becoming forums for research and innovation.
Two person Interaction Recognition Based on Effective Hybrid Learning

Action recognition is an essential task in computer vision due to the variety of prospective applications, such as security surveillance, machine learning, and human–computer interaction. The availability of more video data than ever before and the lofty performance of deep convolutional neural networks also make it essential for action recognition in video. Unfortunately, limited crafted video features and the scarcity of benchmark datasets make it challenging to address the multi-person action recognition task in video data. In this work, we propose a deep convolutional neural network–based Effective Hybrid Learning (EHL) framework for two-person interaction classification in video data. Our approach exploits a pre-trained network model (the VGG16 from the University of Oxford Visual Geometry Group) and extends the Faster R-CNN (region–based convolutional neural network a state-of-the-art detector for image classification). We broaden a semi-supervised learning method combined with an active learning method to improve overall performance. Numerous types of two-person interactions exist in the real world, which makes this a challenging task. In our experiment, we consider a limited number of actions, such as hugging, fighting, linking arms, talking, and kidnapping in two environment such simple and complex. We show that our trained model with an active semi-supervised learning architecture gradually improves the performance. In a simple environment using an Intelligent Technology Laboratory (ITLab) dataset from Inha University, performance increased to 95.6% accuracy, and in a complex environment, performance reached 81% accuracy. Our method reduces data-labeling time, compared to supervised learning methods, for the ITLab dataset. We also conduct extensive experiment on Human Action Recognition benchmarks such as UT-Interaction dataset, HMDB51 dataset and obtain better performance than state-of-the-art approaches.
Parental legacy, demography, and admixture influenced the evolution of the two subgenomes of the tetraploid Capsella bursa-pastoris (Brassicaceae)

Allopolyploidy is generally perceived as a major source of evolutionary novelties and as an instantaneous way to create isolation barriers. However, we do not have a clear understanding of how two subgenomes evolve and interact once they have fused in an allopolyploid species nor how isolated they are from their relatives. Here, we address these questions by analyzing genomic and transcriptomic data of allotetraploid Capsella bursa-pastoris in three differentiated populations, Asia, Europe, and the Middle East. We phased the two subgenomes, one descended from the outcrossing and highly diverse Capsella grandiflora (CbpCg) and the other one from the selfing and genetically depauperate Capsella orientalis (CbpCo). For each subgenome, we assessed its relationship with the diploid relatives, temporal changes of effective population size (Ne), signatures of positive and negative selection, and gene expression patterns. In all three regions, Ne of the two subgenomes decreased gradually over time and the CbpCo subgenome accumulated more deleterious changes than CbpCg. There were signs of widespread admixture between C. bursa-pastoris and its diploid relatives. The two subgenomes were impacted differentially depending on geographic region suggesting either strong interploidy gene flow or multiple origins of C. bursa-pastoris. Selective sweeps were more common on the CbpCg subgenome in Europe and the Middle East, and on the CbpCo subgenome in Asia. In contrast, differences in expression were limited with the CbpCg subgenome slightly more expressed than CbpCo in Europe and the Middle-East. In summary, after more than 100,000 generations of co-existence, the two subgenomes of C. bursa-pastoris still retained a strong signature of parental legacy but their evolutionary trajectory strongly varied across geographic regions.
miR‐15b and miR‐16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells

microRNAs are endogenous small noncoding RNAs that regulate gene expression negatively at posttranscriptional level. This latest addition to the complex gene regulatory circuitry revolutionizes our way to understanding physiological and pathological processes in the human body. Here we investigated the possible role of microRNAs in the development of multidrug resistance (MDR) in gastric cancer cells. microRNA expression profiling revealed a limited set of microRNAs with altered expression in multidrug‐ resistant gastric cancer cell line SGC7901/VCR compared to its parental SGC7901 cell line. Among the downregulated microRNAs are miR‐15b and miR‐16, members of miR‐15/16 family, whose expression was further validated by qRT‐PCR. In vitro drug sensitivity assay demonstrated that overexpression of miR‐15b or miR‐16 sensitized SGC7901/VCR cells to anticancer drugs whereas inhibition of them using antisense oligonucleotides conferred SGC7901 cells MDR. The downregulation of miR‐15b and miR‐16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl‐2 protein. Enforced mir‐15b or miR‐16 expression reduced Bcl‐2 protein level and the luciferase activity of a BCL2 3′ untranslated region‐based reporter construct in SGC7901/VCR cells, suggesting that BCL2 is a direct target of miR‐15b and miR‐16. Moreover, overexpression of miR‐15b or miR‐16 could sensitize SGC7901/VCR cells to VCR‐induced apoptosis. Taken together, our findings suggest that miR‐15b and miR‐16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2. © 2008 Wiley‐Liss, Inc.
Is infant neural sensitivity to vocal emotion associated with mother-infant relational experience?

An early understanding of others’ vocal emotions provides infants with a distinct advantage for eliciting appropriate care from caregivers and for navigating their social world. Consistent with this notion, an emerging literature suggests that a temporal cortical response to the prosody of emotional speech is observable in the first year of life. Furthermore, neural specialisation to vocal emotion in infancy may vary according to early experience. Neural sensitivity to emotional non-speech vocalisations was investigated in 29 six-month-old infants using near-infrared spectroscopy (fNIRS). Both angry and happy vocalisations evoked increased activation in the temporal cortices (relative to neutral and angry vocalisations respectively), and the strength of the angry minus neutral effect was positively associated with the degree of directiveness in the mothers’ play interactions with their infant. This first fNIRS study of infant vocal emotion processing implicates bilateral temporal mechanisms similar to those found in adults and suggests that infants who experience more directive caregiving or social play may more strongly or preferentially process vocal anger by six months of age.