Miracle-dz/UniFAR-FTUs huggingface dataset:
Iron Overload and Hematopoetic Stem Cell Transplantation

Hematopoietic stem cell transplantation (HSCT) is an established treatment modality with a curative potential in a variety of hematological disorders. Although remarkable advances in transplant immunology and supportive care allowed widespread use of HSCT, transplant related morbidity and mortality remain as a problem [1-7]. Early complications including si‐ nusoidal obstruction syndrome (SOS), hemorrhagic cystitis, engraftment syndrome, idio‐ pathic pneumonia syndrome (IPS), infections and graft versus host disease (GVHD) are the major causes of morbidity and non relapse mortality (NRM). High doses of radiotherapy and chemotherapy of the conditioning regimen have adverse effects on all organs and tis‐ sues of the recipient, which also triggers several early and late effects of variable intensity [1, 3, 5-8]. Iron overload (IO) is a relatively common condition in patients with hematological malignacies and HSCT recipients. Free iron which accompanies IO might contribute to the already existing prooxidant state in HSCT recipients by inducing the formation of reactive oxygen species (ROS). Tissue peroxidation and organ damage, as a consequence, contribute to the development of some early transplant complications [2, 4, 5, 9]. Increasing number of transplants performed each year and improved transplant techniques result in a rise in the number of long term survivors. The primary goal of HSCT is to cure the primary disease. However long term transplant related morbidity might be very challenging and might sig‐ nificantly impair the quality of life. Late effects might be the consequence of the direct toxici‐ ty of chemoradiotherapy and/or the immunologic complications mainly consisting of GVHD. Besides the secondary late effects including osteoporosis and dental caries, very late effects, namely cardiovascular toxicity considered as tertiary late effect may also occur. Among this wide spectrum of complications, IO has a substantial role as a contributor to liv‐
International Journal of Science Engineering and Advance Technology

International Journal of Science Engineering and Advance Technology is a peer-reviewed, open access scientific journal that publishes original research works in the areas of the Science ,Engineering, Pharmacy, Medical and Social Science. Authors are encouraged to contribute articles which is not published or not under review in any other journal. The aim of this journal to give oppportunity to the young and learner researcher to publish their article and can interact with the eminent researchers and scientist worldwide.
ALTERAÇÕES MORFOFISIOLÓGICAS E COMPORTAMENTAIS MEDIADAS POR DELTAMETRINA EM INSETOS AQUÁTICOS

GUTIERREZ, Yeisson M.Sc., Universidad Federal de Viçosa, October of 2015. Morphophysiological and behavioral changes mediated by deltamethrin in aquatic insects. Advisor: Eugênio E. de Oliveira. Although there is already a considerable scientific framework on the lethal effects of insecticides on target organisms, there are few records of sublethal effects of these compounds and, in the case of aquatic insect fauna, this information is virtually nonexistent. Pyrethroids are potent neurotoxic insecticides that have sodium channels as their primary sites of action. These compounds are widely used in agriculture and in the control of insect vectors of disease, which has allowed that part of the molecules applied in the field end up reaching aquatic ecosystems. Aquatic insects are customarily used as bio-indicators of water quality, which make them excellent study models of the contamination of water bodies by deltamethrin. Within this context, this project was conducted to evaluate the morphophysiology of action as well as behavioral changes in aquatic insects triggered by sublethal exposure to deltamethrin. To this end, the mayflies Callibaetis radiatus were used in experiments aimed at ascertaining both the toxicity and the possible disturbances at cellular and tissue level in the nervous system and midgut resulting from exposure to deltamethrin, and heteropteran predators (Notonectidae), Buenoa tarsalis and Martarega bentoi, were used in experiments aimed to determine the toxicity of deltamethrin and possible changes in swimming activity of these bugs when exposed to sublethal concentrations of this insecticide. Significant reductions in the survival of C. radiatus was observed at concentrations of deltamethrin ≥ 0.5 μg/L. Cytomorphological changes were light in the brain (presence of pyknotic nuclei) and severe in thoracic ganglia (neuronal vacuolization and deformation of bodies, appearance of voids between the perineurium and the cortical region, and the presence of pyknotic nuclei) and in the midgut (retraction of the muscular layer, cytoplasm vacuolization, disorganization of the nucleus and cytoplasm) of C. radiatus when these insects were exposed to the sublethal concentrations 0. 25μg/L. However, immunofluorescence and DNA integrity analysis showed that these changes did not cause cell death. In experiments with aquatic heteropterans, the results showed that B. tarsalis is a more sensitive species than M. bentoi to the presence of deltamethrin. The survival of these organisms was reduced at all concentrations tested, and short-term exposure to
18th ICCRTS: C2 in an Underdeveloped and/or Denied Environment

The DoD’s envisioned role shift for humans from operators to future autonomous systems supervisors presents significant challenges for developing effective decision support. What decision support will supervisors need to effectively oversee autonomous systems? What will their task needs be and how can we support them with usable and useful supervisory human-machine interfaces (HMIs) and tools? Here, we inform the requirements and design of future decision support through a systematic cognitive engineering and analysis process. Structured interviews with 27 unmanned systems experts were carefully sequenced across four groups, with results and artifacts from one group informing the next interviews. Interviews focused on supervisory monitoring and intervention tasks and were designed to feed a userand task-centered, scientifically-principled HMI design process to develop the decision support. The interviews informed this design process by populating three key design artifacts: (1) a model of current and future tasks, (2) their allocation across humans and automation, and (3) the necessary supporting human-automation exchanges. A framework for system designers to allocate tasks across humans and automation was extended to provide an objective basis for subject matter experts to contribute their expectations for future automation. The interview results show how today’s task needs are not met by current HMIs and tools, and how persisting with them is unlikely to meet the future needs of more nuanced supervisory decision making. Our results inform the design of future supervisory HMIs that target and mitigate today’s capability gaps and shed light on how to begin to achieve the DoD vision.
INFRA‐RED PHOTOGRAPHY OF SUBCUTANEOUS VEINS

(1) GRAY, A. M. K. —Arch. of Derm, and Syph. , December, 1926, xiv, p. i)3o. (2) BALLANTYNE, J.W. —The Diseases and Deformities of the Foetus, 1895, ii. Edinburgh : Oliver & Boyd. (3) KNOPFELMACHER, W. —Jahrb. f. Kinderheilk. , 1897, xlv, p. 177. (4) CHANNON, H . J., and HARRISON, G. A. ^Biochem. Journ. , 1926, xx, p. 84. (5) FABYAN, M. —BUU. Johns Hopkins Hosp. , 1907, xviii, p. 349. (6) BEHNHEIM-KARRER. —Schweiz. med. Wochenschr. , 1922, iii, p. 12. ^7) KEILMANN, K. —Zeitschr. f. Kinderheilk. , 1922, xxxiii, p. 298. (8) CAROL W . L . L . , and VAN DER ZANDE, F. —Nederl. Tijdschr. v. Geneesk. , 1925, lxix, p. 1317. (9) WORINCTER, P . , and WEINER, G. —Rev. Frang. de Ped. 1928, iv, p. 57. (10) DISS and WORINGER, F. —Bull, de la Soc. Frang. de Derm, et de Syph. , 1929, vii, p. 960. (11) Fox, U. —Arch. of Derm, and Syph. , 1933, xxvii, p. 237. (12) HARRISON, G. A. ~Arch. of Dis. in Childhood, 1926, i, pp. 63 and 123. (13) KOHNSTAM, G. L . S. , and HERBERT, F . K. ^Ibid., 1927, ii, p. 349.
Controlling electronic structure of single-layered HfX3 (X=S, Se) trichalcogenides through systematic Zr doping

Department of Chemistry, Hokkaido University, Sapporo 060-8510, Japan Center for Materials research by Information Integration (CMI2), National Institute for Materials Science (NIMS), 1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, Japan Physics Department, Faculty of Science, Dokuz Eylül University, 35390 Izmir, Turkey Department of Physics, Adnan Menderes University, 09010 Aydın, Turkey Department of Physics, University of Maryland-Baltimore County, Baltimore, MD 21250, USA
Motivating Mobile App Adoption: Evidence from a Large-scale Randomized Field Experiment

Prior literature has established a positive association between mobile app adoption and customers’ purchase behavior. However, it is not clear whether firms can actively influence customers’ mobile app adoption and increase their purchases. Using a randomized field experiment involving 250,000 customers, we investigate i) whether and how a firm can motivate customers to adopt mobile apps and ii) the causal effect of induced mobile app adoptions on customers’ purchase behaviors. We find that i) both providing information and monetary incentive can lead to significant increase in customers’ mobile app adoption, with the relative increase 447% and 146%, respectively; ii) the effect of mobile app adoption varies greatly depending on how customers are motivated. Although providing monetary incentives may lead to larger increase in mobile app adoption, such induced adoption does not result in more purchases in the long run. In contrast, providing information leads to effective mobile adoption that sustainably increases customers’ purchases, and overall profits of the firm. We further examine customers’ multichannel browsing and purchase behavior and find additional evidence for how induced app adoptions affect customers’ purchase behaviors. In summary, by leveraging a randomized field experiment, our study provides actionable insights for firms designing interventions to motivate effective mobile adoptions. Incentives vs. Information in Motivating Mobile App Adoption Conference on Information Systems and Technology, Nashville 2016
Chirurgie orthopédique des tumeurs osseuses

La prise en charge chirurgicale des tumeurs osseuses malignes de l'enfant et de l'adolescent comporte trois etapes. Le diagnostic, qui necessite toujours une biopsie, puis le traitement local de la tumeur, habituellement chirurgical, et enfin, le traitement des complications orthopediques tardives de la chirurgie ou de la radiotherapie, qui ne sera pas developpe ici.
It’s coffee time: Caffeine across a range of concentrations is not associated with higher heart rates in Daphnia magna

There are many factors that can affect the contractibility of cardiac muscle, such as exposure to stimulants such as caffeine. Using Daphnia Magna as models, we exposed them to different concentrations of caffeine to study the change in heart rate contractibility by determining their heart beats per minute. We used two experimental groups, one control group, and three trials were run for each group to accurately compare the difference in heart rate. Our results showed that there was no significant increase in the heart rate in Daphnia as the concentration of caffeine was increased. Our experiment studies not only the effects of caffeine but also the effects of different concentrations on Daphnia’s heart rate, separating it from previous research. Knowing this could greatly benefit the engineer of synthetic cardiac muscles and their ability to maintain a consistent heart rate when exposed to stimulants.
PARTICIPATORY ARCHITECTURAL CHANGE MANAGEMENT IN ATM SYSTEMS

PACAS WP5, the validation package, is a transversal work package aimed at validating all the steps (or “Activities”) of the project and to guide, support and integrate the results of all the Validation Workshops of PACAS. The objectives of this work package range from the definition of the concept to the analysis and validation of the outputs of all the phases of the project. This deliverable defines the high-level PACAS concept, the overall approach to validation, including planned Workshops and their corresponding objectives, the evaluation criteria and indicators. Furthermore, it deals with the process that leads to the identification of a suitable Advisory Board (AB) of stakeholders for the project and the design phases to build the reference validation use case and scenarios. Finally, this deliverable describes the plan for the end-to-end inclusion of the AB in the validation process. D5.1 – CONCEPT SCENARIOS AND VALIDATION PLAN ©2016 University of Trento, Deep Blue, SINTEF, Utrecht University. All rights reserved. Licensed to the SESAR Joint Undertaking under conditions 5 Table of
Internet addiction as a predictor of depression, anxiety and stress (DASS)

The present study was conducted to study the impact of Internet Addiction on Depression, Anxiety and Stress in males and females among College Students in Jammu. The study was carried out on the total sample of Hundred Students out of which fifty were male students and fifty were female students. The variables of the study was Internet Addiction and Depression, Anxiety and Stress (DASS). A significant difference in both the scales i.e., Internet Addiction and Depression, Anxiety and Stress (DASS) and a Positive correlation between Internet Addiction and Depression, Anxiety and Stress(DASS) was found.24% problematic internet users and 2%significant problematic users was found. 31%severe cases of depression,58% extremely severe cases of Anxiety and 45% moderate cases of stress was found. Internet addiction predict 19.6% of DASS as a whole variable using simple linear regression was found.
Using MATLAB for Analysis of TRAP System

This article describes a Matlab function for reading and processing file outputs from a structure of classifiers. These classifiers neural nets are used in speech recognition based on temporal trajectories (TRAP) of energy in frequency bands. This nonstandard approach is introduced and the program is presented. The utility of resulting figures is enhanced by the possibility of reading and displaying results from all critical bands at once. Resulting analyses are more focused on the reliability of classifiers than on the basic accuracy measure. The first uses colors and their depth to display both cues, reliability and accuracy, in one informative picture. Others are focused on more precise measures, where it is possible to precisely define classifier mistakes.
Hepatoprotective Effect of Anisotes trisulcus on Thioacetamide-induced Hepatic Cirrhosis in Male Albino Mice

Histologically, thioacetamide (TAA) is a well-known toxic compound that induces liver cirrhosis and other metabolic disorders which may lead to serious complications. The potential of Anisotes trisulcus as a hepatoprotective herb was evaluated in experimentally-induced, TAA-mediated liver cirrhosis in mice model. Healthy male mice were employed in the current study and randomly assigned into four groups. The first group was the normal control, while the second groups were exposed to TAA by intraperitoneal injection. Mice of the third group orally received A. trisulcus leaves extract alongside the TAA intraperitoneal injection. The fourth group was only supplemented with A. trisulcus leaves extract. After three months of experimental treatments, histopathological examination of liver tissue sections from TAA-treated mice with revealed shown increase in the deposition of extracellular collagen and fibrosis. Alterations of tissue architecture and large fibrous septae were observed as a result of collagen condensation around the lobules. Obtained result of the current study showed that the leave extract of A. trisulcus possess hepatoprotective effect against TAA-induced liver cirrhosis by preventing the histopathological alterations. Supplementation of A. trisulcus aqueous extract may confer antioxidant effect and could be an excellent supportive component in the treatment of liver
CARTILAGE ON CHIP

The principal function of the cartilage is to provide a smooth, lubricated surface for articulation and to facilitate the transmission of loads between the bones [1]. This function is ensured by the collagen distribution present in the cartilage. Cartilage tissues are neither vascularized nor innervated. They are mainly composed of dense extracellular matrix (ECM) with a sparse distribution of highly specialized cells called chondrocytes.
Developing new drugs and vaccines for schistosomiasis

The sequencing of two medically important species of schistosomes, Schistosoma mansoni and S. haematobium provided many opportunities for new approaches for the study of the biology and methods of control of these organisms (Berriman et al, 2009; Young et al, 2011). In order to provide the community with a framework for the use of the genomic data we have developed SchistoDB (www.schistodb.net, version 3.0) that houses the three most medically relevant genomes. We report on genome wide search strategies aiming at the identification of drug targets, development of new active compounds and antigens of interest. Two groups of enzymes are being studied in a combined computational and experimental approach, histone modifying enzymes and signaling kinases. Additionally we are conducting high-throughput in silico screening on every modeled enzyme. Vaccine and diagnostic candidate antigens are being identified by a mixed proteomic and immunoinformatic approach. Background: Schistosomiasis is a neglected human parasitic disease caused by flatworms of the genus Schistosoma (Platyhelminthes: Trematoda). There are currently over 207 million infected and over 700 million at risk, resulting approximately 300,000 deaths annually in 76 countries. There is presently only one drug used for mass treatment, Praziquantel, and no vaccine. In this work we present strategies based on the genomes of three species, mainly S. mansoni, for the development of new countermeasures for controlling this disease. Method: To construct SchistoDB we used the Genomics Unified Schema (GUS)/WDK (www.gusdb.org). SchistoDB integrates genome annotations of S. mansoni, S. japonicum and S. haematobium with several functional genomics datasets, such as ESTs, RNA-Seq, epitopes, and mass spectrometry data, made available by members of the international research community (Webster et al, 2010). The GUS engine supports a variety of complex queries driven by research and development needs. In order to understand evolutionary relationships of S. mansoni proteins, and bring further annotation to the genome, we developed the S. mansoni Phylome. PhylomeDB (http://phylomedb.org/phylome_22) was constructed using the framework developed by HuertaCepas and collaborators (2010) comparing 17 organisms. The identification of histone modifying enzymes (HMEs) and eukaryotic kinases (ePKs) were carried out by sequence similarity using Hidden Markov Models followed by phylogenetic analysis and manual curation of the gene models and annotation. The IBM World Community Grid is being utilized for high throughput modeling and screening of in silico compound
Moving Target Tracking and Imaging Through Scattering Media via Speckle-Difference-Combined Bispectrum Analysis

Target tracking and imaging through scattering media are challenges that must be overcome for important applications in various fields. The fundamental problem is the randomly diffused light in scattering media that prevents the formation of diffraction-limited images. In recent years, speckle correlation has emerged as a powerful approach for restoring targets through scattering media and tracking targets with high scattering. However, this method fails to achieve high-accuracy target tracking in multidimensional motion. Furthermore, retrieving the deterministic phase of a target in a low-resolution speckle pattern is limited. Here, a method based on speckle-difference-combined bispectrum analysis (SDCBA) is presented to simultaneously track and image targets. The proposed SDCBA requires no high-resolution pattern, randomly assigned initial values, nor numerous iterations. The target is tracked simultaneously in multidimension by using speckle difference autocorrelation and restored with the deterministic phase via bispectrum analysis of the low-resolution speckle pattern. This work carries out simulations and experiments to demonstrate simultaneous multidimensional target tracking and imaging in low-resolution speckle pattern through scattering media via the SDCBA. This work will benefit various fields, including biomedical applications, materials science, and military security.
Metastable Olivine Wedge Beneath the Japan Sea Imaged by Seismic Interferometry

The metastable olivine wedge (MOW) within subducted slabs has long been hypothesized to host deep‐focus earthquakes (>300 km). Its presence would also rule out hydrous slabs being subducted into the mantle transition zone. However, the existence and dimensions of MOW remain debatable. Here, we apply inter‐source interferometry, which converts deep earthquakes into virtual seismometers, to detect the seismic signature of MOW without influence from shallow heterogeneities. With data from the Hi‐net, we confirm the existence of MOW beneath the Japan Sea and constrain its geometry to be ~30 km thick at 410‐km depth and gradually thinning to a depth of 580 km at least. Our result supports transformational faulting of metastable olivine as the initiation mechanism of deep earthquakes, although large events (M7.0+) probably rupture beyond the wedge. Furthermore, the slab core must be dehydrated at shallower depth and only transports negligible amount of water into the transition zone.