Miracle-dz/UniFAR-FTUs huggingface dataset:
Model-Oriented Web Service Implementations Compared to Traditional Web Services

Model-Oriented Web Services (MOWS) are a specific kind of Web Services (WS) that employ models for artifacts, including data transmission. They foster reuse due to its higher abstraction levels, and allow to visualize the data as models that represent a common language. However, it is important to study possible disadvantages when compared to traditional WS systems. Therefore, in this paper, we present a study on the impact of MOWS, including technological aspects, and providing comparisons of length of data transmission in a mathematical analysis for attesting its exact difference when comparing MOWS to similarly structured traditional WS. Results include a technical discussion and proof that the length difference has a constant increase when compared to a similarly structured traditional WS. We conclude that MOWS is not recommended to all applications. Still, the differences would be dimmed by compression algorithms and might be considered irrelevant for systems that normally deal with long messages.
Sustained superior long-term outcomes and cytogenetic responses with imatinib mesylate in chronic phase chronic myeloid leukaemia: report from a developing country.

OBJECTIVE Imatinib mesylate is now a standard treatment for chronic myeloid leukaemia. Primary objective of our study was to report long-term survival outcomes in patients receiving Imatinib in chronic phase. Secondary objectives included determination of cytogenetic responses and toxicity profile of Imatinib mesylate. METHODS Three-hundred and four consecutive patients with chronic phase chronic myeloid leukaemia were evaluated between January 2001 to December 2007, for event-free survival, overall survival, complete cytogenetic response and toxicity profiles. Event-free and overall survivals were calculated by Kaplan-Meier estimates. Cox regression analysis was performed to evaluate the prognostic factors for survival. Univariate and multivariate analyses were performed for factors predictive of a complete cytogenetic response. RESULTS Median follow-up was 48 months. Estimated 5-year event-free and overall survivals of all patients were 79% and 86%, respectively. On Cox regression analysis significant predictive factors for event-free survival were age < 50 years (P 0.002), complete cytogenetic response (P < 0.0001), low Sokal score (P 0.007), complete clinical (P < 0.0001) and haematological response (P < 0.0001). Complete cytogenetic response was achieved in 206 (67.8%) patients. On multivariate analysis, low Sokal score (P < 0.0001) and early chronic phase disease (P < 0.0001) emerged as the most significant predictors for achieving a complete cytogenetic response. An estimated 5.8% patients lost their complete cytogenetic response. Grade III/IV toxicity was observed in only 21 patients. CONCLUSIONS Long-term treatment with Imatinib mesylate results in superior and durable responses in chronic phase chronic myeloid leukaemia. Our survival outcomes are similar to reported rates in the Western population.
Deterministic Mean-Field Ensemble Kalman Filtering

The proof of convergence of the standard ensemble Kalman filter (EnKF) from Legland etal. (2011) is extended to non-Gaussian state space models. A density-based deterministic approximation of the mean-field limit EnKF (DMFEnKF) is proposed, consisting of a PDE solver and a quadrature rule. Given a certain minimal order of convergence $\kappa$ between the two, this extends to the deterministic filter approximation, which is therefore asymptotically superior to standard EnKF when the dimension $d<2\kappa$. The fidelity of approximation of the true distribution is also established using an extension of total variation metric to random measures. This is limited by a Gaussian bias term arising from non-linearity/non-Gaussianity of the model, which exists for both DMFEnKF and standard EnKF. Numerical results support and extend the theory.
2 × 2 Tables: a note on Campbell's recommendation

For 2 × 2 tables, Egon Pearson's N − 1 chi‐squared statistic is theoretically more sound than Karl Pearson's chi‐squared statistic, and provides more accurate p values. Moreover, Egon Pearson's N − 1 chi‐squared statistic is equal to the Mantel‐Haenszel chi‐squared statistic for a single 2 × 2 table, and as such, is often available in statistical software packages like SPSS, SAS, Stata, or R, which facilitates compliance with Ian Campbell's recommendations. Copyright © 2015 John Wiley & Sons, Ltd.
Olfactory identification and its relationship to executive functions, memory, and disability one year after severe traumatic brain injury.

OBJECTIVE To explore the frequency of posttraumatic olfactory (dys)function 1 year after severe traumatic brain injury (TBI) and determine whether there is a relationship between olfactory identification and neuropsychological test performance, injury severity and TBI-related disability. METHOD A population-based multicenter study including 129 individuals with severe TBI (99 males; 16 to 85 years of age) that could accomplish neuropsychological examinations. Olfactory (dys)function (anosmia, hyposmia, normosmia) was assessed by the University of Pennsylvania Smell Identification Test (UPSIT) or the Brief Smell Identification Test (B-SIT). Three tests of the Delis-Kaplan Executive Function System (D-KEFS) were used to assess processing speed, verbal fluency, inhibition and set-shifting, and the California Verbal Learning Test-II was used to examine verbal memory. The Glasgow Outcome Scale-Extended (GOSE) was used to measure disability level. RESULTS Employing 2 different smell tests in 2 equal-sized subsamples, the UPSIT sample (n = 65) classified 34% with anosmia and 52% with hyposmia, while the B-SIT sample (n = 64) classified 20% with anosmia and 9% with hyposmia. Individuals classified with anosmia by the B-SIT showed significantly lower scores for set-shifting, category switching fluency and delayed verbal memory compared to hyposmia and normosmia groups. Only the B-SIT scores were significantly correlated with neuropsychological performance and GOSE scores. Brain injury severity (Rotterdam CT score) and subarachnoid hemorrhage were related to anosmia. Individuals classified with anosmia demonstrated similar disability as those with hyposmia/normosmia. CONCLUSIONS Different measures of olfaction may yield different estimates of anosmia. Nevertheless, around 1 third of individuals with severe TBI suffered from anosmia, which may also indicate poorer cognitive outcome.
Design of Half Mode Substrate Integrated Waveguide (HMSIW) filter with series Defective Microstrip Structure (DMS) for Ku band operation

Design of a Half Mode SIW Filter (HMSIW) for Ku band operation has been presented in this paper. Defective Microstrip Structure (DMS) consisting of a single and multiple slots has been introduced and the effect has been studied. The structure is smaller in size and also cost effective due to the half TE10 mode. The effect of introducing single and multiple resonant slots to create stopband within the passband of the filter has been studied validated with simulation results. The proposed technique has been found quite useful in designing HMSIW bandpass filters.
A real-time motion-feature-extraction image processor employing digital-pixel-sensor-based parallel architecture

A VLSI image processor capable of extracting motion features from moving images in real time has been developed employing row-parallel and pixel-parallel architectures based on the digital pixel sensor (DPS) technology. Directional edge filtering of input images is carried out in row-parallel processing to minimize the chip real estate. To achieve a real-time response of the system, a fully pixel-parallel architecture has been explored in adaptive binarization of filtered images for essential feature extraction as well as in their temporal integration and derivative operations. As a result, self-speed-adaptive motion-feature-extraction has been established. The chip was designed and fabricated in a 65-nm CMOS technology and used to build an object detection system. Motion-sensitive target image localization was demonstrated as an illustrative example.
Maritime Semantic Labeling of Optical Remote Sensing Images with Multi-Scale Fully Convolutional Network

In current remote sensing literature, the problems of sea-land segmentation and ship detection (including in-dock ships) are investigated separately despite the high correlation between them. This inhibits joint optimization and makes the implementation of the methods highly complicated. In this paper, we propose a novel fully convolutional network to accomplish the two tasks simultaneously, in a semantic labeling fashion, i.e., to label every pixel of the image into 3 classes, sea, land and ships. A multi-scale structure for the network is proposed to address the huge scale gap between different classes of targets, i.e., sea/land and ships. Conventional multi-scale structure utilizes shortcuts to connect low level, fine scale feature maps to high level ones to increase the network’s ability to produce finer results. In contrast, our proposed multi-scale structure focuses on increasing the receptive field of the network while maintaining the ability towards fine scale details. The multi-scale convolution network accommodates the huge scale difference between sea-land and ships and provides comprehensive features, and is able to accomplish the tasks in an end-to-end manner that is easy for implementation and feasible for joint optimization. In the network, the input forks into fine-scale and coarse-scale paths, which share the same convolution layers to minimize network parameter increase, and then are joined together to produce the final result. The experiments show that the network tackles the semantic labeling problem with improved performance.
Inhibition of the Ethanol-induced Potentiation of α1 Glycine Receptor by a Small Peptide That Interferes with Gβγ Binding*

Background: Gβγ interaction with GlyR is an important determinant in ethanol potentiation of this channel. Results: A small peptide, RQHC7, can inhibit ethanol potentiation of GlyR currents. Conclusion: Results with RQHC7 indicate that ethanol mediated potentiation of GlyR is in part by Gβγ activation. Significance: Molecular interaction between Gβγ and GlyR could be used as a target for pharmacological modification of ethanol effects. Previous studies indicate that ethanol can modulate glycine receptors (GlyR), in part, through Gβγ interaction with basic residues in the intracellular loop. In this study, we show that a seven-amino acid peptide (RQHC7), which has the primary structure of a motif in the large intracellular loop of GlyR (GlyR-IL), was able to inhibit the ethanol-elicited potentiation of this channel from 47 ± 2 to 16 ± 4%, without interfering with the effect of Gβγ on GIRK (G protein activated inwardly rectifying potassium channel) activation. RQHC7 displayed a concentration-dependent effect on ethanol action in evoked and synaptic currents. A fragment of GlyR-IL without the basic amino acids did not interact with Gβγ or inhibit ethanol potentiation of GlyR. In silico analysis using docking and molecular dynamics allowed to identify a region of ∼350Å2 involving aspartic acids 186, 228, and 246 in Gβγ where we propose that RQHC7 binds and exerts its blocking action on the effect of ethanol in GlyR.
MESSENGER Observations of the Spatial Distribution of Planetary Ions Near Mercury

The polar regions of Mercury are important sources of material for its ionized exosphere. Global measurements by MESSENGER of the fluxes of heavy ions at Mercury, particularly sodium (Na+) and oxygen (O+), exhibit distinct maxima in the northern magnetic-cusp region, indicating that polar regions are important sources of Mercury’s ionized exosphere, presumably through solar-wind sputtering near the poles. The observed fluxes of helium (He+) are more evenly distributed, indicating a more uniform source such as that expected from evaporation from a helium-saturated surface. In some regions near Mercury, especially the nightside equatorial region, the Na+ pressure can be a substantial fraction of the proton pressure.
The influence of white matter fibre orientation on MR signal phase and decay

MRI phase images of the brain exhibit excellent contrast and high signal‐to‐noise ratio. It has been shown recently that the phase contrast not only depends on a tissue's magnetic susceptibility but also on its architecture, which offers new ways of studying biological tissues in vivo. We combined diffusion tensor imaging and multi‐echo susceptibility‐weighted imaging to investigate the relationship between white matter fibre orientation and gradient‐echo phase and magnitude. The local angle between white matter fibres and the main magnetic field was computed from the principal diffusion direction. The phase and signal decay of the gradient‐echo images revealed a characteristic relationship with fibre orientation. The phase is in agreement with a recently reported model of cerebral white matter phase contrast in MRI. Copyright © 2010 John Wiley & Sons, Ltd.
Methods Involving Light Variation for Isolation of Cyanobacteria: Characterization of Isolates from Central Australia

We report the isolation of organisms belonging to a range of cyanobacterial genera from the remote arid region of central Australia, together with a preliminary characterization of their temporal modes of nitrogen fixation. We rendered unialgal Dermocarpa and Myxosarcina spp. (Section II organisms), LPP group B: type X (Section III), and Scytonema and Nostoc spp. (Section IV). We developed an isolation procedure based on a combination of published methods and applicable to a broad spectrum of cyanobacterial genera. We found light intensity to be a critical variable in our methodology; it was also an important determinant of the proportions of different organisms growing in stable mixtures.
Analysis and realisation of the LINC transmitter using the combined analogue locked loop universal modulator (CALLUM)

A novel modulator and transmitter subsystem is presented which provides amplification through RF synthesis. The technique has the potential for 100% dc to RF conversion efficiency whilst providing a highly linear output. Based on the LINC concept, the modulator employs feedback around the entire transmitter subsystem to maintain linearity and efficiency with practical component tolerances. <<ETX>>
Long-Term Renewable Energy Planning Model for Remote Communities

This paper presents a novel long-term renewable energy (RE) planning model for remote communities (RCs), considering the characteristics of diesel-based RCs in Canada and other parts of the world such as Alaska and northern Chile. Over the past few years, there has been a significant increase in assessing and deploying RE projects in northern remote locations. The model proposed in this paper adds to such efforts by creating a multiple-year community planning tool that can be used to determine economic and technically feasible RE solutions, considering the current operating structures, electricity pricing systems, subsidy frameworks, and project funding alternatives under which RE can be deployed in RCs. The proposed model is implemented in a case study for the Kasabonika Lake First Nation community in northern Ontario. The case study shows that RE projects can be feasible under current operating conditions, for a set of funding alternatives that share the economic risks.
THE EFFECTS OF INCONSISTENT PARENTING ON THE DEVELOPMENT OF UNCERTAIN SELF-ESTEEM AND DEPRESSION VULNERABILITY

Although there are numerous reports of how adverse parent-child interactions during development might contribute to problems with self-esteem and later risk for depression, less research has focused on the potential deleterious effects of parenting inconsistency during development. The purpose of the current study was to test whether reports of inconsistent parent-child interactions during development are associated with uncertain self-esteem and depression vulnerability in adulthood. In order to test this possibility, a previously depressed group (high-risk) of college students and a never depressed group (low-risk) of college students were compared on measures of trait self-esteem, self-esteem certainty, parental bonding (care and over-protection), and a new retrospective measure of parenting consistency (Consistency of Parenting Scale; COPS; Luxton, 2007). Structural equation modeling (SEM) was used to test a series of structural and latent means models that examined whether inconsistent parenting contributes to the development of uncertain self-esteem and depression risk---above and beyond the influence of negative parenting dimensions alone (i.e., low care and overprotection). The results indicated that only consistency of mother care was associated with certainty of selfesteem in the high-risk group and only mother consistency of control was associated with selfesteem certainty in the low-risk group. The high-risk group also reported higher levels of father inconsistency of care and lower levels of both trait self-esteem and self-esteem certainty compared to the low-risk group. Although there was not a general moderating effect of gender on the association between the parenting variables and self-esteem certainty, gender by depression status model tests indicated that the association between inconsistent mother control and certainty of self-esteem was only among low-risk women and the association between inconsistent mother care and self-esteem certainty was only among high-risk women. Both high-risk women and high-risk men reported higher levels of father inconsistency of care compared to low-risk women. These findings are important because they suggest that inconsistent parenting practices might have an adverse influence on the development of the selfesteem of children, which may make children more vulnerable for depression later in life. Limitations and future directions are also discussed.
Familial hypertrophic cardiomyopathy: clinical features, molecular genetics and molecular genetic testing

Hypertrophic cardiomyopathy is a Mendelian disease characterized by cardiac hypertrophy. It has a prevalence of 1:500 individuals and is the most common cause of sudden death in the young. Other complications include heart failure and the need for heart transplantation. Hypertrophic cardiomyopathy is due to sarcomeric gene mutations, however, phenocopies with myocardial hypertrophy can be due to triplet-repeat syndromes (Friedreich ataxia and myotonic dystrophy), mitochondrial and metabolic diseases. In a peculiar form associated with Wolf–Parkinson–White syndrome, the disease is caused by mutations in the γ2 regulatory subunit of the AMP-activated protein kinase gene, leading to a glycogen storage cardiomyopathy. In spite of the growing knowledge about the molecular basis of hypertrophic cardiomyopathy, very little is still known about the genotype–phenotype correlations and their clinical implications. In this review, the clinical and molecular genetics of hypertrophic cardiomyopathy are described.
Effect of Albizia lebbeck on liver and kidney function of Plasmodium berghei infected mice

Purpose- Drug resistance to antimalarials has been a major hindrance in the treatment of malaria. The present study was aimed at investigating the biochemical and histopathological effect of ethanolic bark extract of Albizia lebbeck (EBEAL) on Plasmodium berghei infected mice. Methods- To assess the schizonticidal activity, animals were infected with parasite on D0 and orally administered EBEAL concentrations (100-1000 mg/kg; G4-G8) along with normal control (G1), infected control (G2) and CQ, 5mg/kg (G3) respectively. Serum activity of ALP, SGOT, SGPT and levels of bilirubin were assessed as biomarkers of liver function and creatinine and urea as indicators of renal sufficiency on D7. Results -Significant increase (p<0.0001) in enzyme activities of infected control than normal were observed on D7. Serum ALP activity was elevated in G4-G8 while SGOT and SGPT levels were within the normal range contrary to the positive control (CQ) which exhibited significant increase (p< 0.0001) in enzyme activities on D7. In all the extract treated groups, bilirubin levels were slightly elevated. However, kidney function tests were within normal range in treated groups but increased in infected control (G2) on D7. Transverse sections of infected liver illustrated gross lesions whereas slight changes in hepatic architecture were also evident in CQ (5 mg/kg) and EBEAL (100 mg/kg) treated liver exhibiting sinusoidal dilations and haemozoin depositions on D28. This indicates safety of extract to host liver. Necrotic changes in renal morphology was evident in P. berghei infected kidney. CQ treated group exhibited impaired renal morphology, whereas, haemozoin deposition was observed in kidney after EBEAL (100 mg/kg) treatment. Conclusions-The present study has established that administration of EBEAL has no adverse effect on the liver and kidney of mice infected with malaria.
Piece of string can assess cardiovascular risk, study finds

Measuring a person’s waist with a piece of string is a better predictor of cardiovascular risk than using body mass index (BMI) alone, researchers have said. A study published at the European Congress on Obesity in Prague this week supported the finding that a person was at lower cardiovascular risk if they kept their waist measurement to less than half their height measurement.1 This could be done by personnel with minimal training and resources by …
Analysis of Sorting as a Streaming Application

Expressing concurrency of applications has always been a challenging and error-prone task, yet effective use of multi-core processors and hardware implementations requires that the concurrency of applications be well represented and understood. One approach to the expression of concurrency is streaming. In this paper I express the classic problem of sorting in the streaming paradigm, and explore various algorithmic and architectural design parameters.
Recovery from delusions. Three phases documented by patient's interpretation of research procedures.

The experiences of acutely psychotic patients during research procedures reveal important characteristics of the process of recovery from delusional thought. Changes in the patients' perceptions and interpretations of testing experiences parallel changes in their clinical status and are used to demonstrate the continuum between delusional and nondelusional thinking. Three specific phases are defined: the delusional, double-awareness, and nondelusional phases. The interaction between this regular sequence of changes and the patients' participation in research is examined with particular reference to the process of recovery from delusions.