Miracle-dz/UniFAR-FTUs huggingface dataset:
Genomics and Proteomics in Nutrition

MOUSE MODELS OF HUMAN DISEASES AND GENE TRANSCRIPTION Genetic Modifiers in Rodent Models of Obesity, Y. Wang, P.M. Nishina and J. Naggert Quantitative TrAit Loci in obesity and TYPE II Diabetes in Rodents, J.H. Kim The Human Sweet Tooth and its Relationship to Obesity, A.H. McDaniel and D.R. Reed The Adipose Renin-Angiotensin System: Genetics, Regulation, and Physiologic Function, B.H. Voy, S. Kim, S. Urs, M. Derfus, Y. -R. Heo, R. Joshi, F. Massiera, M. Teboul, G. Aihaud, A. Quignard-Boulange, and N. Moustaid-Moussa Regulation of Fat Synthesis and Adipogenesis, K. -H. Kim, M.J. Griffin, J.A. Villena, and H.S. Sul Transcriptional Regulation of Energy Metabolism in Liver, M.T. Nakamura, GENOMICS: LARGE SCALE ANALYSIS OF GENE EXPRESSION BY MICROARRAY Design and Analysis of Microarray Studies for Obesity Research, M. -Pierre St. Onge, G.P. Page, M. DeLuca, K. Zhang, K. Kim, S.B. Heymsfield, and D. Allsion Solving Clinical Problems in Nutrition Research with Microarrays, S. Smith Genomic Approaches to Understanding Vitamin D Action, J. Fleet Gene Expression Profiling in Adipose Tissue, N. Moustaid-Moussa Phytochemicals and Gene Expression, O. Mezei and N. Shay Gene Expression Profiling of Immune Cells: Application for Understanding Aging of Immune Cells, S.N. Han and S. Meydani Improving the Nutritional Value of Cereal Grains Using a Genomic Approach, L. Shi and T. Zhu PROTEOMICS: LARGE SCALE ANALYSIS OF PROTEIN EXPRESSION AND REGULATION Proteomics and Genomics in Health & Disease, J.A. Carroll and C.E. Mathews 2D-Gel Proteomics Studies on Leukocytes, I.C. Gerling and M.J. Pabst Proteomics: Tools for Nutrition Research in the Post-Genomic Era, A. Grider Proteomic Analysis of the Adipocyte Secretome, Ibarrola Mass Spectrometry Strategies for Proteomic Studies, M. Belghazi and H. Rogniaux Bioinformatics Tools, S.M Lin, K.F. Johnson, and S.W. Kullman Statistical Principles for Analysis of Array Experiments, A.M. Saxton and E.B. Moser Index
New world primates : ecology, evolution, and behavior

This book, whose contributors are leading experts on various aspects of New World monkeys, explores the tremendous diversity to be found among neotropical primate species that have adapted to the highly varied Central and South American ecosystems. These studies provide striking similarities and intriguing differences from, the heretofore better known adaptions in the Old World.
Gene regulatory network for lateral root formation in Arabidopsis thaliana

Post-embryonic lateral root organogenesis plays an essential role in defining plant root system architecture, and therefore plant growth and fitness. The aim of the thesis is to elucidate the gene regulatory network regulating lateral root development and de novo root meristem formation during root branching in the model plant Arabidopsis thaliana by combining a system-biology based analysis of lateral root primordium transcritome dynamics with the functional characterization of genes possibly involved in regulating lateral root organogenesis.The first part of the thesis deals with the identification the target genes of PUCHI, an AP2/EREBP transcription factor that is involved in controlling cell proliferation and differentiation during lateral root formation. We showed that loss of PUCHI function leads to defects lateral root initiation and primordium growth and organisation. We found that several genes coding for proteins of the very long chain fatty acid (VLCFA) biosynthesis machinery are transiently induced in a PUCHI-dependent manner during lateral root development. Moreover, a mutant perturbed in VLCFA biosynthesis (kcs1-5) displays similar lateral root development defects as does puchi-1. In addition, puchi-1 loss of function mutant roots show enhanced and continuous callus formation in auxin-rich callus induction medium, consistent with the recently reported role of VLCFAs in organizing separated callus proliferation on this inductive growing medium. Thus, our results show that PUCHI positively regulates the expression of VLCFA biosynthesis genes during lateral root development, and further support the hypothesis that lateral root and callus formation share common genetic regulatory mechanisms.A second part of the thesis specifically addresses the issue of identifying key regulators of root meristem organization in the developing lateral root primordium. Material enabling the tracking of meristem cell identity establishment in developing primordia with live confocal microscopy was generated. A gene network inference was run to predict potential regulatory relationships between genes of interest during the time course of lateral root development. It identified potential regulators of quiescent center formation, a key step in functional organization of the lateral root primordia into a new root apical meristem. The characterization of some of these candidate genes was initiated.Altogether, this work participated in deciphering the genetic regulation of lateral root formation in Arabidopsis thaliana .
Réalisation et caractérisation des diodes organiques de redressement pour la récupération de l’énergie électromagnétique

Ce travail de these s’inscrit dans le cadre du projet INTERREG Luminoptex et vise a realiser des diodes organiques de redressement pour des applications de recuperation d’energie electromagnetique pour de l’eclairage ambiant autonome sur support textile. Des diodes a base de pentacene et de polymere P3HT ont ete fabriquees selon deux configurations: verticale et coplanaire en utilisant aussi bien des procedes simples et peu couteux que des procedes de lithographie electronique. Les performances de ces diodes ont ete ameliorees par l’utilisation de monocouches auto assemblees SAM de PFBT (2,3,4,5-6 pentafluorobenzenethiol) qui permettent de reduire les barrieres d’injection des porteurs de charges denviron 0.5eV. Dans le cas des diodes polymeres, une couche d’injection a base de P3HT dope au Triflate de cuivre a ete etudiee et utilisee pour l’amelioration de l’injection. Des rapports de rectification eleves ont ete obtenus ( 107) avec des tensions de fonctionnement tres faibles (de 20 a 80mV). Les travaux de simulation ont montre par ailleurs, que ces diodes peuvent atteindre des frequences de fonctionnement de l’ordre du GHz.Ces composants ont ete ensuite realises sur substrat flexible de papier pour un transfert sur les surfaces textiles.
Surveying the Development of Authorship Identification of Text Messages

People typically use multiple messaging systems and send text messages concurrently by different messaging systems such as SMS, email, Twitter, and Facebook. This means that these forms of messaging systems are highly integrated into people’s everyday activities. Moreover, forensic science has had many challenges in many different kinds of crimes, differing from physical crimes to computer mediated crime activities. Identification of suspects has become crucial for law enforcement due in particularly to the anonymity that the internet and associated services provide and identify the ownership of messages. In this paper, survey the development of existing author identification have been done by establishing a comprehensive review of author identification to determining the core approaches and techniques utilized. Furthermore, this study also examines possible challenges in author identification and points to some of the open problems which need to be tackled.
Ecological comparisons of thermally affected aquatic environments.

ments are becoming commonplace in this country and throughout the world. The increased usage of nuclear power for the production of electricity insures that even greater demands will be placed on aquatic ecosystems used as recipients of excess heat. A critical need exists to un derstand how thermally affected environ ments function biologically.1 The U. S. Atomic Energy Commission's (aec) Savannah River plant near Aiken, S. C, provided an ideal situation for the examination of a variety of aquatic systems in regard to thermal waste disposal. Initial studies characterized the thermally affected systems in terms of their general ecology. The objective of the present study was to compare species composition and the relative abundance of certain components (vascular aquatic plants, fishes, and rep tiles ) of three reservoirs differently affected by thermal effluent from nuclear reactors. * One of the reservoirs received thermal effluent, another was recovering following former intense thermal loading, and the third area had had no direct elevation of water temperatures. The emphasis in this report is on some of the major, more ob vious, and non-migratory aquatic compo * As a result of continued field studies through out the year, several additional species of plants, fish, and reptiles have been reported from each of the study areas since preparation of the original manuscript. This is to be expected because much of the data were from collections during the sum mer period. The only possible change in the trends reported herein is that several fish species apparently enter Pond C from small streams dur ing reactor shutdown or during cooler parts of the year. Because Pond B is landlocked and Pond C is not, this may eventually result in more fish species occurring in the heated lake. nents of the ecosystems in question. This does not imply a low regard for the im portance of other components of the sys tem, such as algae, plankton, macro-inver tebrates, and amphibians. Work presently in progress on these and other facets will be reported at a later time. Study Area
Réponses cellulaires vis-à vis de l’exposition au cadmium chez les animaux

Most consequences of cadmium exposure arise from the interaction with a range of bio-molecules and by interference with homeostasis of other metals. Zinc is the biologically metal that most closely resembles Cd. A High Resistant Zinc (HZR) cellline derived from HeLa cells was found to be resistant to Cd toxicity. The induction of endoplasmic reticulum stress decreases resistance of HZR cells to Cd exposure. Also tyrosine catabolism, may be as a way of producing melanin, is involved in adaptation to high zinc concentrations, as witnessed by proteomic analysis. The Cd resistance of HZR cells is due to the limitation of intracellular cadmium. The over-expression of major efflux pumps was not responsible for expelling Cd from HZR cells. Instead, Cd uptake was limited by a not already known Cd transporters characterized in other cell types. A genome-wide analysis of the HZR transcripts underlines a series of signalisation pathways in which the number of cellular components that are sensitive is too large to identify individual molecules directly responsible for handling zinc or Cd. Ln mammals, Cd intoxication could lead to anemia. At the cellular level, iron homeostasis is regulated at the translational level by the IRE (Iron Responsive Element)! IRP (Iron Regulatory Proteins) system. Mice, orally treated with Cd, show neither anemia nor changes in tissue IRP activities, although significant accumulation of Cd in these organs. Ln HeLa cells Cd decreases the IRPI stability, contrary to the HZR cells. The cellular responses to Cd depend on the cellular conditions, most probably by the interplay among the signalling cascades evidenced in the HZR transcriptomic studies.
Myocardial abscess – case report of a survivor of a fatal disease

Myocardial abscess is a rare and usually a fatal c relatively a rare manifestation of staphylococcal septicemia especially in pediatric population. Here we are presenting a case of intramural myocardial abscess following right thigh a immunocompetent child with no structural heart disease. Incision and drainage of thigh abscess with aggressive appropriate antibiotic therapy saved the child despite the fatal myocardial abscess. Even in the absenc endocarditis in staphylococcal septicemia, it is mandatory to look for myocardial abscess for early diagnosis and betteroutcome. A high index of clinical suspicion is required to make a prompt diagnosis.
e-Governance Implementation – A Literature Review Analysis

e-Governance has become an imperative mode for Governments across the globe to engage and transact with citizens. From being an alternate channel to becoming the norm, e-Governance has come a long way. However, e-Governance implementation is being challenged by impediments like resource inadequacy – financial, process reengineering, IT & Human, etc. Lately, e-Governance implementation has been at the centre of research, which in turn has resulted in an increase in the number of papers dedicated to the subject. As result, it is prudent to analyse the existing literature to identify various aspects associated with the implementation of e-Governance along with methodologies being applied in the process. Accordingly, the paper aims to analyse the determining factors of e-Governance as identified in research studies published in the last one and a half decade (2000-2015). Based on the investigation of extant literature available on the subject, it has been established that technological, financial, Human resource and Information privacy and security related factors are the major determinants of e-Governance. However, paper in the process of identification duly acknowledges the limitations of the study and has suggested research directions for further research. Originality/value – The originality of the research lies in the finding presented over a 15 year period in e-Governance research. The above was achieved by analysing This has been achieved by analysing publication in databases of EBSCO and Emerald.
Super-Resolution OCT Based on α-Stable Distributions and Sparse Representations

—We present a new approach to single-image super-resolution in Optical Coherence Tomography (OCT) images. Indeed, although OCT is the one in-vivo retinal imaging modality offering the highest resolution, this is still far below what microscopy techniques can achieve, albeit ex-vivo. In this work we investigate a non-convex regularization technique using a multivariate generalization of the minimax-concave (GMC) scheme and a forward-backward splitting (FBS) algorithm. Based on the observation that sparse representations of OCT images are heavy-tailed, an α -stable dictionary is employed. The resulting algorithm is tested on real OCT retinal images of murine eyes. Signiﬁcant deblurring and general quality enhancement is noticed and in most cases our method provides the best results both objectively and subjectively.
Fin vs. Tech: How Does New Knowledge Creation and Lack of Trust in Financial Services Incumbents Influence the Emergence and Financing of Fintech Start-Ups?

In the aftermath of the global financial crisis, new financial technology (fintech) start-ups have emerged to challenge the long-established position of financial services incumbents. Drawing on resource-based theory and institutional theory, we investigate how the emergence of fintech start-ups and their financing is shaped by new regional knowledge creation and the lack of trust in financial institutions across 21 OECD countries, 226 regions and over the 2007 – 2014 period. While we find that knowledge generated in the IT sector is much more salient for fostering new fintech start-ups than knowledge generated in the financial services sector, we also find an increasing (decreasing) importance of new knowledge created in the financial services sector (IT sector) as fintech start-ups grow and seek financing. Our paper unveils that in the years where the level of trust in financial institutions falls within a region, there is an increase in the financing provided to fintech start-ups, however regions with historically low average levels of trust in financial institutions attract less fintech investment overall.
SDN Controller Requirements for Next Generation Telco PaaS

This paper presents an analysis of requirements to Software Defined Network (SDN) Controllers (SDNC), from the point of view of the Telco’s Next Generation Platform as a Service (NGPaaS) functional and architectural needs. Numerous requirements have been identified, which can be grouped in 4 categories: domain-based, modularity-based, related to the SDN and Network Function Virtualization (NFV) integration and finally policy-based. These requirements are later mapped into the ONOS SDN controller, with the scope of identifying possible gaps and points of improvement.
Cell patterning for spatially standardized cell biology

The onus in modern cell biology is on the development of reproducible, The onus in modern cell biology is on the development of reproducible, develop cell patterning capabilities that are accessible to biologists and to demonstrate new and innovative analytical methods based on the spatial control of cell positioning for widespread cell biology applications as well as fundamental research applications. Plasma stencilling methods for cell patterning were developed which are simple, rapid, inexpensive, reproducible, effective and potentially universal cell line patterning techniques. PDMS micropatterning techniques were also developed to achieve a high resolution patterning capability over large areas and with absolute freedom of design while remaining efficient, cheap, simple and highly reproducible. These features make these methods accessible and desirable to biologists and microengineers alike. As a result from these developments, novel bio-analytical platforms were produced and innovative assays are presented. Cell patterning using these novel techniques was successfully used for the parallel and mass production of 3D spheroids, with high reproducibility and excellent control of the uniformity of spheroid size. A spatially standardized analytical display for high throughput neurotoxicity screening is also presented where cell patterning offers a route to standardize the neurite outgrowth lengths. In addition, a microfluidic system was also used to efficiently pattern and couple single cells by differential resistance pathway principles and validates the concept of using the natural behaviour of cells for mechanical operations within microengineered environments. Taken together, this thesis demonstrates that it is possible to exploit cell micropatterning technologies for the realization of spatially standardized, highly reproducible and quantitative cell biology assays for both fundamental research and commercial applications.
The Role of extracellular matrix in development

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FATORES CRÍTICOS DE SUCESSO DE ERP EM UMA ORGANIZAÇÃO PÚBLICA E AS PRESSÕES INSTITUCIONAIS (Critical Factors of ERP Sucess in a Public Organization and Institutional Pressures)

O objetivo da pesquisa foi analisar como o gerenciamento dos Fatores Criticos de Sucesso “lideranca da implementacao” e “limitacoes do sistema” influencia a implementacao de ERP em uma organizacao publica, considerando as pressoes institucionais. Os conceitos utilizados na investigacao foram pressoes institucionais e aspectos sobre os fatores criticos abordados. O estudo de caso analisou a implementacao de um ERP em uma Universidade Federal e utilizou dados coletados atraves de entrevistas, documentos e observacao nao participante. Os principais achados indicam que as pressoes institucionais exercem influencias que dificultam o gerenciamento dos elementos de FCS. Ademais, foram encontradas evidencias de que as pressoes institucionais podem moderar o projeto de implementacao, mas nao determinam seu sucesso. http://dx.doi. org/10.21714/1679-18272019v17Esp.p163-177
Chemical Mechanisms of Drug Action

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Funding classical music: A comparison of Norwegian public policy and practitioner perspectives

This thesis examines ways in which public funding of the classical music sector is legitimised by the Norwegian public sector and by classical music practitioners working in Norway. The thesis examines public policy documents ssued by public authorities on the three levels of government in Norway, and the funding rationales that are expressed in these. With regards to the practitioner perspective, the thesis is informed by 37 in-depth semi-structured interviews of classical music practitioners. The thesis contributes to knowledge within the research area of cultural policy studies in three different ways. First, the thesis provides a new way of categorising funding rationales for the arts. This categorisation is built on a systematic review of the empirical material used in the thesis, and it is informed by formal requirements of typologies. The thesis ﬁnds that the funding is underpinned by three forms of rationales: Equality, collective well-being and the intrinsic value of art. Secondly, the thesis contributes to knowledge about the relationship between public funding rationales for the classical music sector that are expressed by practitioners and by the Norwegian public sector, respectively. The rationales expressed by practitioners and public authorities are compared within the structure of a thematic analysis. The main themes of thisanalysis are the three aforementioned rationales: Equality, collective well-being and the intrinsic value of art. The interviewees generally expressed a stronger preference for the equality rationale, and a more spiritual conception of the intrinsic value of art, than the Norwegian public sector. On the other hand, the creative economy rationale, which isconsidered an important rationale by the Norwegian public sector for the promotion of collective well-being, was considered less relevant by the interviewees. Thirdly, the thesis discusses possible interpretations of the viewpoints expressed by the interviewees and by the public sector. More speciﬁcally, the thesis discusses possible ways of understanding how some general worldviews might inform the interviewees’ ways of legitimising public funding of the sector within which they are employed, and possible waysof understanding why the interviewees emphasised other public funding rationales than the Norwegian public sector does.
Redesigning the Ivory Tower : Academic Entrepreneurship as a New Calling Supporting Economic Growth

Innovation in the world of markets safeguards the viability of the companies or the organizations and the society within which they operate. Entrepreneurship’s role is significant in the promotion and economic development of countries and it is the young generation who should be given adequate knowledge to develop competent skills. The core of entrepreneurship may be found at academic entrepreneurship that moulds younger generations and may contribute to innovation and technology transfer. This may have positive effects on local economic growth. This paper examines the significance of academic entrepreneurship providing an overview of current trends and future outlook. Synergies need to be initiated between educators, different actors, stakeholders and organizations from local community which is strategic for economic development. The university needs to change in order to cope with the changes in society and in order to be able to contribute to the development of technology-oriented companies with economic consequences on local, national and international economic growth.