Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation eines Inverted Classroom Konzepts in der makroökonomischen Lehre

Im Rahmen der Vorlesung "Volkswirtschaftslehre und -politik" hat die Fakultat Betriebswirtschaft der OTH Amberg-Weiden ein Projekt gestartet, um die Wirkungen einer neuen Lernplattform auf das Studienergebnis zu untersuchen. In Verbindung mit der Implementierung der Lernplattform erfolgte auch eine Anpassung des Veranstaltungskonzeptes, wobei jedoch grundlegende Elemente wie Inhalte und die Gestaltung der Klausur konstant gehalten wurden. Der wesentliche konzeptionelle Unterschied zur traditionellen Veranstaltungsform besteht darin, dass die Studierenden die Inhalte zunachst in Eigenregie erlernen und einuben. Erst danach findet jeweils die Prasenzveranstaltung statt. Ausgangspunkt fur die Veranderung war insbesondere das Ziel, die Studienergebnisse der Veranstaltung zu verbessern. Dahinter stehen Idee und Hoffnung, dass sich die Studierenden regelmasig mit der Materie auseinandersetzen und diese besser verstehen, wenn sie sich die Inhalte zunachst selbst aneignen und dabei ihrem individuellen Lernrhythmus nachgehen konnen. Unterstutzt werden soll dieser Prozess durch zahlreiche Ubungsmoglichkeiten. Folgender Bericht geht dabei naher auf das Projekt ein und stellt daraus resultierende Evaluationsergebnisse vor.
An Introduction to the Special Issue on Occupational Exoskeletons

Maury A. Nussbaum , Brian D. Lowe , Michiel de Looze , Carisa HarrisAdamson and Marty Smets Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA, USA; National Institute for Occupational Safety and Health, Cincinnati, OH, USA; TNO, Leiden, The Netherlands; Occupational and Environmental Medicine, University of California, San Francisco, CA, USA; Advanced Manufacturing, Ford Motor Company, Glendale, MI, USA
The Mediating Role of Strategic Planning on the Determinants of Sustainable Urban Tourism: Empirical Evidence from Tanzania

This study investigates the mediating role of strategic planning on the relationship between the destination determinants and sustainable urban tourism in Tanzania. The paper is guided by both social exchange theory and stakeholders’ theory. Four determinants of sustainable urban tourism were explored namely, stakeholders’ financial support, level of responsibility, technical support and information for the promotion and development of tourism and support from the local communities. Unlike other variables which were positively related to sustainable urban tourism, the support from the local communities was found to have a negative relationship with sustainable urban tourism. Structural equation modelling technique revealed that strategic planning had a full mediating effect of two sustainable urban tourism determinants namely, level of responsibility and support from the local communities. It was also revealed that the effects of stakeholders’ financial support and technical support on sustainable urban tourism are partially mediated by strategic planning. It is recommended that strategic planning policy initiatives to promote sustainable urban tourism development should focus on stakeholders’ willingness and participation, awareness on the sustainability issues, enhance technology innovation and proper infrastructure development
Reliability of the 6-minute walk test and cardiac autonomic markers in active and sedentary older women

Objetivou-se verificar a reprodutibilidade do teste de caminhada de 6 minutos (TC6) e de marcadores autonomicos cardiacos pos-esforco em idosas fisicamente ativas e sedentarias. Dezoito idosas ativas (64,2 ± 3,1 anos; 63,0 ± 2,7 kg; 1,52 ± 0,06 m; 26,9 ± 2,7 kg.m-2) praticantes de Tai Chi Chuan (≥6 meses de pratica) e 18 idosas sedentarias (64,0 ± 3,7 anos; 63,8 ± 8,9 kg; 1,49 ± 0,05 m; 28,4 ± 3,5 kg.m-2) foram submetidas a dois TC6 com uma semana de intervalo. Foram medidas a frequencia cardiaca de recuperacao (FCR) de um e dois minutos (FCR1’ e FCR2’, respectivamente) e variabilidade da frequencia cardiaca (VFC) pos-esforco. A reprodutibilidade foi verificada pelos: coeficiente de correlacao intraclasse (CCI) com 95% de intervalo de confianca; analise de concordância de Bland-Altman; e coeficiente de variacao (CV). O desempenho no TC6 (528,8±71,4 m e 473,2±62,4 m; CV=7,9% e CV=8,5%) apresentou alta reprodutibilidade (CCI=0,86) em idosas ativas e sedentarias, respectivamente. Similarmente, as medidas pos-esforco da FCR1’ (29,0±11,0 bpm e 17,0±8,0 bpm; CV=30,1% e CV=40,2%) e FCR2’ (36,0±10,0 bpm e 24,0±9,0 bpm; CV=23,7% e CV=22,8%) apresentaram alta reprodutibilidade (CCI≥0,84 e CCI≥0,80) em ambos os grupos. Quanto a VFC verificou-se reprodutibilidade moderada (CCI≥0,57; CV=35-47%) em idosas ativas e moderada-alta nas sedentarias (CCI=0,65-0,76; CV=34-69%). Todas as variaveis apresentaram concordância em ambos os grupos. Conclui-se que o TC6, FCR e VFC pos-esforco sao instrumentos reprodutiveis na avaliacao da capacidade funcional e controle autonomico cardiaco em idosas ativas e sedentarias.
THE EFFECT OF DHAWALSAN-1 (CURANGA FEL-TERRAE [LOUR.]) EXTRACT VERSUS METFORMIN ON THE METABOLIC AND INFLAMMATORY CHARACTERISTICS OF PATIENTS WITH NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS Research Article

ABSTRACT Objectives: The prevalence of Type 2 diabetes mellitus (T2DM) continues to rise at an exponential rate around the world as well as in South-East Asia regions. This study compared the effect of metformin and dhawalsan-1 (Curanga fel-terrae [Lour.]) extract on metabolic and inflammatory characteristics in patients with newly diagnosed T2DM. Methods: In this preliminary study, consecutive sampling was used to select 24 newly diagnosed T2DM subjects to be randomly assigned into two groups: One group received metformin 3 × 500 mg/day and another group received dhawalsan-1 extract 2 × 100 mg/day, in a double-blind fashion. Clinical characteristics of the patients were assessed before and after the 12-week treatment period. Results: After the 12-week treatment, in metformin group, a significant decrease was noted in waist circumference (p=0.005), fasting plasma glucose (FPG; p=0.017), glycosylated hemoglobin (HbA1c) (p=0.021), and homeostasis model of assessment of β-cell function (HOMA-B; p=0.020). In dhawalsan-1 group, a significant decrease was noted in FPG (p=0.012), HbA1c (p=0.006), and HOMA-insulin resistance (p=0.033), and a significant increase was noted in adiponectin (p=0.008). No significant differences were found between metformin and dhawalsan-1 group in any measured clinical characteristic after 12 weeks. Conclusions: This preliminary study indicated that dhawalsan-1 (C. fel-terrae [Lour.]) extract was effective in improving metabolic characteristics and significantly increased adiponectin levels in patients with newly diagnosed T2DM. The improvement also seemed to be comparable with that of metformin. Yet, Further larger studies are required to confirm these promising results. Keywords: Type 2 diabetes mellitus, Metformin, Dhawalsan-1 (Curanga fel-terrae [Lour.]).
A Difficult Balance: Editorial Peer Review in Medicine

Leeds Castle, like Sheffield Park, is a trap set by the English Tourist Board more than 200 miles away from the northern industrial city it seems to belong to. Happily, a distinguished band of medical editors met with no difficulty in seeking out its moated beauty during the celebrations in 1990 of one and a half centuries of publication of the British Medical Journal . Any discussion of the future of medical publications has to take into account the possibility of a paper-free world. In that world—depressing or bright depending on where you look at it from— the bound journal gradually disappears. Doctors, already used to getting their patients' records by calling them up from computer to screen, will, by pressing a key or twitching a mouse, move to an inquiry mode for information that used to appear on the printed page. At first sight, the 16 contributions to the Leeds
Design optimisation of an axial‐flux reluctance magnetic coupling based on a two‐dimensional semi‐analytical model

In this study, design optimisation of an axial-flux reluctance magnetic coupling is presented. The optimal design procedure is based on a two-dimensional (2D) semi-analytical model defined at the mean radius combined with a multi-objective genetic algorithm (NSGA-II). In order to take into account the end-effects in the radial direction, a correction factor is defined to improve the torque and the axial-force determination. The obtained results are compared with those of 3D non-linear finite element simulations and experimental results. It is shown that the proposed semi-analytical model is very accurate and requires very little computing time.
The use of cilostazol in intermittent claudication in patients with peripheral arterial disease

Chromanie przestankowe jest najczestszym objawem choroby tetnic obwodowych (PAD). Wydluzenie dystansu wolnego od bolu uzyskuje sie poprzez leczenie chirurgiczne, endowaskularne oraz odpowiednią farmakoterapie. Inhibitory fosfodiesterazy III (PDE) są grupą lekow, ktore wykazują bardzo silny efekt antyagregacyjny. Oprocz tego mają dzialanie wazodylatacyjne, hipolipemizujące i antyproliferacyjne, co sprawia, ze są przedmiotem licznych publikacji naukowych. Cilostazol jest najlepiej zbadanym inhibitorem PDE. Choc niepozbawiony dzialan niepoządanych, lek ma udowodniony wplyw na wydluzenie dystansu chromania przestankowego. W porownaniu z placebo i pentoksyfiliną istotnie wplywa na maksymalny dystans chromania (MWD) i dystans wolny od bolu (PWD). Ponadto skutecznie zapobiega restenozie po leczeniu endowaskularnym naczyn wiencowych i obwodowych. Cilostazol moze byc takze alternatywą w przypadku zjawiska oporności na tradycyjne leki przeciwplytkowe. W wytycznych TASC II rekomenduje sie stosowanie 3–6-miesiecznej terapii cilostazolem w celu zlagodzenia objawow chromania przestankowego. Leczenie wymaga monitorowania i weryfikacji specjalisty.
Susceptibility-Weighted Imaging for Investigating the Effects of Drainage Veins in Cerebellar Infarction

Background: The phase value of susceptibility weighted imaging (SWI) can quantitatively measure the content of deoxyhemoglobin in veins, thus facilitating understanding of the mechanisms of drainage veins in cerebellar infarction areas. Objectives: To explore the clinical application value of the drainage veins in acute cerebellar infarction. Patients and Methods: SWI was used to measure the phase value of the bilateral cerebellar hemispheres in 30 normal volunteers. In addition, phase values, expressed as Δφ, were analyzed in 18 patients with cerebellar infarction. The scanning sequences included SWI, arterial spin labeling, and diffusion weighted imaging. Results: The phase value of the infarct area was higher than that of the contralateral region (P = 0.001) and was negatively correlated with regional cerebral blood flow in the infarct area (r = -0.433, P = 0.027). However, analysis of the regional cerebral blood flow revealed a positive correlation with the regional apparent diffusion coefficient (r = 0.566, P = 0.003), but the phase value was not correlated with the regional apparent diffusion coefficient of the infarct area (r = -0.293, P = 0.146). Using receiver operating characteristic curve analysis, we determined the phase value of drainage veins and the regional cerebral blood flow value of the critical infarction in the ischemic penumbra of the cerebellar infarction to be 301 spin and 22.25 mL/(min·100g), respectively. Conclusion: Our study showed the relevance of using phase value and its correlation with cerebral blood flow to characterize cerebellar infarction. In addition, our findings suggested possible venous reverse perfusion and venous congestion in the infarcted cerebellar hemisphere, which may be critically related to the development of infarct. Furthermore, our approach using a combination of non-invasive imaging parameters including the susceptibility imaging, cerebral perfusion and diffusion may be helpful in the diagnosis and management of stroke involving the cerebellum.
THE EFFECT OF DER, TATO, ROA AND SHARE PRICE TO PBV (Studies on the food and beverage industry on the Indonesia Stock Exchange period of 2012-2018)

This research is to find out the influence of DER, TATO, ROA and Share Price to PBV on companies listed in Indonesia Stock Exchange retail sub sector ffod and beverage period 2012-2019. The sample selection in this research using saturated sampling method and got 7 companies that match the criteria, so that 49 data were obtained. The research data is obtained from Indonesia Stock Exchange. The method used in this research is panel data multiple regression analysis and it is found that the more appropriate model used is fixed effect. From result of research got value of adjusted R-Square equal to 79,12%. Partially show that DER have negative and significant effect to PBV. TATO, Share Price variable partially had positive and significant effect to PBV. ROA variable partially have positive and no significant effect to PBV.
Effect of selected factors on the body condition of dairy cows managed in the free-stall and tie-stall housing systems

The analysis involved results of 6891 body condition evaluations carried out on 680 Polish Holstein-Friesian Blackand-White cows from two herds belonging to the same owner, although managed in different husbandry systems. The evaluation was carried out within two years using a 5-point scale, with an accuracy of 0.25 points. It was found that the most frequent score was 3.0 BCS (more than 24% of cows), in the tie-stall system, and 3.25 BCS (over 26%), in the free-stall housing system. The distribution of BCS scores of the cows with different daily productivity, of different ages and evaluated in different seasons of the year was significantly correlated with the applied housing system. Cows with the highest daily milk yield (>35 kg), younger cows (in the second lactation) and those evaluated in the summer had the least favorable distribution of body condition scores and their average values as compared to other groups. It was shown that cows kept on tether were more often receiving extreme body condition scores, i.e. not more than 2.0 points or 4.0 and more BCS points, as compared to cows managed in the free-stall housing system.
Deciphering the Electronic Transitions of Thiophene‐Based Donor‐Acceptor‐Donor Pentameric Ligands Utilized for Multimodal Fluorescence Microscopy of Protein Aggregates

Abstract Anionic pentameric thiophene acetates can be used for fluorescence detection and diagnosis of protein amyloid aggregates. Replacing the central thiophene unit by benzothiadiazole (BTD) or quinoxaline (QX) leads to large emission shifts and basic spectral features have been reported [Chem. Eur. J. 2015, 21, 15133‐13137]. Here we present new detailed experimental results of solvent effects, time‐resolved fluorescence and examples employing multi‐photon microscopy and lifetime imaging. Quantum chemical response calculations elucidate how the introduction of the BTD/QX groups changes the electronic states and emissions. The dramatic red‐shift follows an increased conjugation and quinoid character of the π‐electrons of the thiophene backbone. An efficient charge transfer in the excited states S1 and S2 compared to the all‐thiophene analogue makes these more sensitive to the polarity and quenching by the solvent. Taken together, the results guide in the interpretation of images of stained Alzheimer disease brain sections employing advanced fluorescence microscopy and lifetime imaging, and can aid in optimizing future fluorescent ligand development.
Safety of a Weekly Administration of 10 mg/kg of Liposomal Amphotericin B for Antifungal Prophylaxis in Allogeneic Stem-Cell Transplant and Acute Leukemia Patients.

Background Optimal antifungal prophylaxis approach for patients undergoing chemotherapy, acute leukaemia (AL) or allogeneic stem cell transplant (ASCT) for haematological malignancies has yet to be identified in this high risk setting. Patient and Methods An open-label, pilot multicentre study - initiated at Henri Mondor and St-Louis Hospitals (10 patients), Paoli-Calmettes Institute being secondary involved (13 patients) - was conducted between February 2004 and June 2005 in adult patients receiving induction or consolidation chemotherapy for AL or a myeloablative conditioning regimen for ASCT. Patients were either treated for 4 weeks (AL) from the beginning of chemotherapy or 8 weeks (ASCT) from transplant. Treatment consisted of a 2 hour weekly infusion of 10mg/kg liposomal amphotericin B (LAB). Premedication was not allowed prior to day 1 study drug infusion. The primary endpoint was the incidence of reported adverse events occurring during the course of prophylaxis treatment. Results Twenty three patients (14 males and 9 females), mean age 44 years (range: 20 to 79) were treated in this interim analysis (8 ASCT and 15 AL). Safety was monitored with particular attention to infusion-related reactions (IRRs) and nephrotoxicity. In a total of 60 infusions, 5 IRRs (8.3%) occurred (flush, shock, thoracic pain, bone pain and dyspnoea). These were exclusively observed on day one in 5 patients (21%). Seven patients (30%) reached serum creatinine (SCr) ≥1.5 times their baseline values. In the AL group, no patient discontinued LAB or required dose reduction during the study. In the ASCT group, 4 patients discontinued after the first infusion, 3 for IRRs and one for SCr increase related to the study drug and other factors, including reactions to concomitant drugs. One additional ASCT patient had discontinued study drug following the third infusion for SCr increase. Mean duration of prophylaxis was 18 days (range: 10–28) in the AL patients and 14 days (range: 6–31) in the ASCT patients. Conclusion A weekly dose of 10 mg/kg appears to be very well tolerated during induction or consolidation therapy for AL. In the ASCT setting where multiple drugs are concomitantly administered, appropriate timing for the initiation of high dose LAB prophylaxis is yet to be determined in order to optimise the safety profile of this regimen.
Crosstalk between invadopodia and the extracellular matrix

The scaffold protein Tks5α is required for invadopodia-mediated cancer invasion both in vitro and in vivo. We have previously also revealed a role for Tks5 in tumor cell growth using three-dimensional (3D) culture model systems and mouse transplantation experiments. Here we use both 3D and high-density fibrillar collagen (HDFC) culture to demonstrate that native type I collagen, but not a form lacking the telopeptides, stimulated Tks5-dependent growth, which was dependent on the DDR collagen receptors. We used microenvironmental microarray (MEMA) technology to determine that laminin, collagen I, fibronectin and tropoelastin also stimulated invadopodia formation. A Tks5α-specific monoclonal antibody revealed its expression both on microtubules and at invadopodia. High- and super-resolution microscopy of cells in and on collagen was then used to place Tks5α at the base of invadopodia, separated from much of the actin and cortactin, but coincident with both matrix metalloprotease and cathepsin proteolytic activity. Inhibition of the Src family kinases, cathepsins or metalloproteases all reduced invadopodia length but each had distinct effects on Tks5α localization. These studies highlight the crosstalk between invadopodia and extracellular matrix components, and reveal the invadopodium to be a spatially complex structure.
A study of psychiatric inpatient suicides

Abstract Objective: The aim of this paper was to elucidate factors associated with inpatient suicide. Method: A retrospective review of inpatient suicides over a 20 year period in the Cavan/Monaghan mental health service was undertaken. Clinical files, statutory reports and Central Statistics Office returns were studied and information was obtained on demography, diagnosis and circumstances of the event. Results: Eight patients committed suicide, giving a rate of 0.55/1,000 discharges and 0.39/100,000 population per year. Depressive illness and Schizophrenia were the diagnoses found. Repeated admissions and long duration of illness were noted. Previous suicidal behaviour was common. Four of the patients were considered a suicide risk at some time during the index admission. Underreporting of the suicides and inaccurate registration of institutional location by the Central Statistics Office were found. Conclusion: More formal clinical procedures in registering suicide risk are recommended. New procedures for investigating inpatient suicides are suggested. Largescale studies at a national level are essential in defining more specific and sensitive risk factors. Procedural changes involving accurate central registration of data are required.
A bond graph approach to integrative biophysical modelling

A major goal of systems biology is to develop comprehensive, multi-scale mathematical models of physiological systems that integrate biological knowledge from the scale of molecules to the scale of tissues and organs. Models on this scale hold great potential in advancing our knowledge of biology and medicine, but they have yet to be achieved in complex biological systems. It is widely acknowledged that constructing large-scale models requires the reuse and integration of existing models; however, model integration is currently challenging because many existing models violate the conservation laws of physics, especially conservation of energy. It is therefore highly desirable to express models in a framework that respects the laws of physics and thermodynamics. Bond graphs are an energy-based modelling framework, initially developed for use in multi-physics engineering systems to help derive equations consistent with the laws of physics. More recently, bond graphs have been applied to the field of biology where they have helped in making models physically and thermodynamically consistent. While bond graphs provide several advantages for large-scale modelling such as thermodynamic consistency and hierarchical modelling, they have yet to be applied to large-scale dynamic models of biological systems. This thesis aims to develop methods based on the bond graph framework to facilitate model reuse and integration. These methods are demonstrated by applying them to biomolecular systems within the cardiac cell. Firstly, bond graphs are applied to membrane transporters, demonstrating that bond graphs can be used to correct thermodynamic inconsistencies within existing models. Secondly, independently developed models of ion channels and transporters are coupled into a model of cardiac electrophysiology, showing that bond graphs can be used to systematically explain the issues of drift and non-unique steady states that affect many existing models. Finally, a generalised method for simplifying models of enzyme kinetics is developed and used to facilitate the development of simple, thermodynamically consistent models of enzymes that are easily incorporated into larger models.
Practical pediatric nephrology Continuous arterial-venous diahemofiltration and continuous veno-venous diahemofiltration in infants and children

Continuous arterial-venous diahemofiltration and continuous veno-venous diahemofiltrafion (CAVH(D)/CVVH(D)) in the infant and pediatric popula- tion is increasingly being utilized in the child needing renal replacement therapy (RRT). Difficulties with infant- and pediatric-specific equipment remains a limitation. The availability of techniques and equipment in this unique population is addressed. Use of this form of RRT as op- posed to hemodialysis or peritoneal dialysis is discussed. The decision for CAVH(D) or CVVH(D) remains an indi- vidual choice.