Miracle-dz/UniFAR-FTUs huggingface dataset:
Protective Effect of Berberine on the Nonalcoholic Fatty Liver Induced by High-Fat Diet in Rats

Objective:To observe the protective effects of berberine on nonalcoholic fatty liver induced by high-fat diet in rats.Methods:Fatty liver disease model was established by feeding rats with high-fat diet.The therapeutic groups were administered with berberine by gavage at the dose of 100 and 200 mg/kg daily.After four weeks,all rats were sacrificed.Liver index,anti-oxidative function,blood and liver lipid were assayed.Results:Berberine decreased the liver index,reduced the content of serum and hepatic triglycerides,lowered the serum free fatty acid level,and increased liver homogenate SOD activity of rats with fatty liver.Conclusion:Bererine can protect rats from nonalcoholic fatty liver disease induced by high-fat diet maybe through lowering blood lipid level and improving hepatic anti-oxidative capability.
Risk factors of proliferative diabetic retinopathy in type 2 diabetes

Objective To explore the morbidity rate and risk factors of proliferative diabetic retinopathy (PDR) in type 2 diabetes. Methods The clinical data of patients, with PDR in 2739 consecutive cases of type 2 diabetes diagnosed in this hospital from 1994 to 2001 were analyed retospectively. The diagnosis of diabetic retinopathy (DR) was confirmed by ophthalmoscopy and fundus fluorescein angiography (FFA). Blood pressure, fasting and postprandial blood sugar, glycosylated haemoglobin(HbA1c), total serum cholesterol, triglyceride, creatinine, and albumin excretion rate were measured. Results The morbidity rate of type 2 DR was 27.8%(761/2739), and the morbidity rate of PDR was 4. 2%(114/2 739) occupying 15% of the patients with DR. The duration, fasting blood sugar, glycosylated haemoglobin, blood pressure and albumin excretion rate were much higher than those in the control ( P 0.01, glycosylated haemoglobin P 0.05). The independent risk factors of PDR were duration of the disease r =0.15, P 0.01) and albumin excretion rate ( r =0.08, P 0.05). The risk factors of PDR were albumin excretion rate and fasting blood sugar ( r =0.13, P 0.05) in patients with longer duration(≥5 years). The morbidity rate of PDR was 2.3%, 5.9% and 12.4% in patients with duration less than 5 years, 5 to 10 years and over 10 years groups, respectively. The morbidity of PDR of the patients in normal albuminuria, microalbuminuria and overt albuminuria group was 2.1%、5.3% and 18. 8% respectively. Conclusions Type 2 diabetes accompanied with PDR is relative to the duration of the diabetes, albumin excretion rate, fasting blood sugar, blood pressure, and glycosylated haemoglobin, in which the duration of the disease, albuminuria and fasting blood sugar are the risk factors of occurance of PDR.
Study for the Relation of Prepregnancy BMI, Gestational Weight Gain and Weight Retention at 42 Days Postpartum

Objective:To describe the relation of pre-pregnant BMI, gestational weight gain and weight retention at 42 days postpartum. And to study the factors that affect the weight changes during pregnancy.Methods:Retrospective study was used in the convenient sample whose pre-pregnant weight, weight before delivery and weight at 42 days postpartum were recorded. Use the questionnaire to collect the related factors.Results:The average gestational weight gain is higher than 12.50 kg.There is significant weight retention at 42 days postpartum (median=7.50 kg). Pre-pregnant BMI, gestational weight gain, feeding methods and some others are factors affect the postpartum weight changes.Conclusion:Many factors effect postpartum weight change. The care should focus on those factors.
2‐(1‐Benzyl‐1H‐indol‐3‐yl­methyl­ene)‐1‐aza­bi­cyclo­[2.2.2]­octan‐3‐one

The title compound, C23H22N2O, was obtained in a condensation reaction of 1-benzyl-1H-indole-3-carbox­aldehyde with 1-aza-bi­cyclo­[2.2. 2]­octan-3-one. The crystal structure indicates the presence of a double bond, connecting an aza­bicyclic ring system to an indole-3-carbox­aldehyde.
1‐Ferrocenyl‐3‐(4‐n‐octoxylphenyl)propane‐1,3‐dione

The title compound, [Fe(C5H5)(C22H27O3)], which forms an extended conjugated system and appears in the enol form, is mainly stabilized by an intra­molecular hydrogen bond. The Fe—C bond distances are nearly equal with a mean value of 2.0312 A. The two cyclo­penta­dienyl rings are almost parallel to each other, as shown by the dihedral angle of 0.97 (17)°. In the structure, ferrocenyl is the more powerful electron-donating group, with the result that the carbonyl group substituted on the benzene ring has the enol form.
Tri­carbonyl­bis(4-methyl-1,3-thia­zole-2(3H)-thionato-N,S2)­tungsten(II)

The title compound, [W(C4H4NS2)2(CO)3], consists of a seven-coordinate tungsten centre with three carbonyl ligands and two planar methyl­thia­zole sulfide ligands, both coordinating bidentately to the W atom through the N and sulfide S atoms. The two 4-methyl­thi­azole sulfide ligands are twisted at an angle of 86.98 (15)° with respect to each other.
4-(m-Chloro­benzyl­amino)-3-phenyl-4,5-di­hydro-1H-1,2,4-triazol-5-one

The conformation of the title compound, C15H13ClN4O, can be described in terms of four essentially planar fragments. The triazole ring is planar within 0.008 A, and its plane, while being almost parallel to the benzene plane of the benzyl­amino group [dihedral angle 2.95 (14)°], forms a dihedral angle of 16.43 (12)° with the plane of its 3-phenyl substituent. The four-atom bridge (triazole)N—N(H)—C(H2)—C(C6H4Cl), linking the triazole moiety with the chloro­phenyl group, is also almost planar, the N—N—C—C torsion angle being −178.82 (13)°. Its mean plane is approximately normal to the triazole and chloro­phenyl planes [dihedral angles 107.08 (10) and 108.81 (10)°, respectively]. Two independent N—H⋯O bonds link the mol­ecules into infinite chains running along the b axis of the crystal.
(±)-3-(2,6-Dichlorophenyl)-1-phenyl-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine

In the title compound, C24H17Cl2NO, the oxazine ring is distorted and adopts an envelope conformation. The dihedral angle between the dichlorophenyl ring and the naphthyl system is 85.30 (13)°. An intra­molecular N—H⋯Cl hydrogen bond is observed.
Trends in Cardiovascular Devices: Resynchronization Therapy and Robotically Assisted Surgery

O f all sectors of the medical device industry, cardiovascular is the most robust, according to analysts. This sector invests heavily in research and enjoys healthy sales. In addition, reimbursement rates for procedures involving cardiovascular devices are among the strongest. Two areas in which there is significant activity are cardiac resynchronization therapy (CRT) and robotically assisted heart surgery. Following is an overview of recent developments and the current issues, as well as a look at the major device manufacturers in these 2 areas.
[N,N′-Bis(5-bromo­salicyl­idene)-o-phenylene­diaminato]copper(II)

In the title compound, {4,4′-di­bromo-2,2′-[o-phenyl­ene­bis­(nitrilo­methyl­idene)]­di­phen­ol­ato-O,N,N′,O′}copper(II), [Cu(C20H12Br2N2O2], the CuII ion shows a slightly distorted square-planar geometry with the N2O2 atoms of the Schiff base imine–phenol tetradentate ligand.
Effects of red clover isoflavones (Promensil) versus placebo on uterine endometrium, vaginal maturation index and the uterine artery in healthy postmenopausal women

Introduction. The risk of breast cancer is increased among menopausal women using HRT. Routine screening mammograms may be harder to interpret in HRT users; breast tissue may be denser and breast tenderness may reduce tolerance of adequate breast compression during mammography. Studies have reported lower specificity and sensitivity of screening mammograms in HRT users. Women are sometimes advised empirically to stop their HRT before screening mammography. We wanted to determine whether a short break from HRT would make a worthwhile difference to the quality of mammograms. In designing the study, established HRT users were surveyed. Although most said they were willing to stop HRT before mammography, 70% said they would not stop for more than four weeks. Methods. 48 women aged 48 to 65 were recruited from a menopause clinic. All had been using standard dose combined HRT for at least six months. Following bilateral oblique view mammograms the women stopped their HRT for four weeks and attended for repeat mammography. The paired mammograms were read by two consultant radiologists who were blinded to their timing. Study participants recorded any breast tenderness throughout the study and discomfort associated with each mammogram. Results. There was no significant difference between the densities of baseline and follow-up mammograms. There was no significant difference in reported breast tenderness and discomfort of mammograms before or after stopping HRT. There was no correlation between an individual's breast symptoms and the quality of her mammograms. Conclusions. This short break from HRT did not appear to make any important contribution to the quality of mammography. A longer break from HRT might have a greater effect but women in our clinic population said they would not tolerate a longer break. There is no value in advising women to stop their HRT a short time before screening mammography.
Professional Learning Communities at Work: Best Practices for Enhancing Student Achievement

This study guide is a companion to the classic book by Richard DuFour and Robert Eaker: Professional Learning Communities at Work: Best Practices for Enhancing Student Achievement. It can be used by individuals, small groups, or an entire faculty to identify key points, raise questions for consideration, and suggest steps that might be taken to promote the Professional Learning Community (PLC) concept in a school or district. This guide is arranged by chapter, enabling readers to either work their way through the entire book or to focus on the specific topics addressed in a particular chapter.
9-Benzyl-3,6-dibromo-9H-carbazole

Two independent mol­ecules comprise the asymmetric unit of the title compound, C19H13Br2N, which was synthesized by N-alkyl­ation of benzyl bromide with 3,6-dibromo-9H-carbazole. The carbazole ring system is essentially planar and forms a dihedral angle with the pendant phenyl ring of 66.0 (2)° [70.6 (2)° for the second mol­ecule]. In the crystal structure, π–π inter­actions and weak C—H⋯Br inter­actions are observed.
5-(tert-Butyldimethylsilyloxy)-1-(2-chloro-5,8-dimethoxyquinolin-3-yl)-3-methylenepentan-1-ol

Novel 5-(tert-butyldimethylsilyloxy)-1-(2-chloro-5,8-dimethoxyquinolin-3-yl)-3-methylenepentan-1-ol (7) was prepared via allylation of 2-chloro-5,8-dimethoxyquinoline-3-carbaldehyde (6) with functionalized allylic iodide as tert-butyl-(3-(iodomethyl)but-3-enyloxy)dimethylsilane (5), in the presence of metallic indium in anhydrous DMF as solvent at ambient temperature. The structure of the synthesized compound was assigned on the basis of elemental analysis and spectral data.
Infants Non-and-lowresponse after Recombinant Yeast Derived Hepatitis B Vaccinated and Influencing Factors Analysis

Objective To understand the non-and-lowresponse of infants after recombinant yeast derived hepatitis B vaccinated and analysis the influencing factors.Methods 2788 infants born during 2004-2005 in Peking,Ningbo and Guangdong were vaccinated with 5μg×3 recombinant yeast derived hepatitis B vaccinated by 0,1,6 months schedule.The seromarks(HBsAg,anti-HBs,anti-HBc)were detected by RIA,and collected some information from the parents by qestionairs.Results After three doses;the min-titres of anti-HBs was 0.18 mIU/ml,the max-titres was 19736.00 mIU/ml,the G-C was 264.33 mIU/ml.The percentage of Non-and low-response WAS 16.89%,with non-response was 1.72% and low-response is 15.17%,in which,males′ was higher than female,premature was higher than mature,low-birthweight infants was higher than normal.but no statistic differents were seen(p0.05). Conclusions Non-and-lowresponse of infant after hepatitis B vaccinated was 16.89%,and the non-respose was 1.72%. No effects of the gender,abortion and birth-weight on non-and-lowresponse werre ibserved.
The comparative study of protective effect of two kinds of natural antioxidants on spinal motoneurons following brachial roots avulsion

Objective To compare the effect of natural antioxidants TA9001 and EGb761 on c-jun, NOS expression and survival of spinal motoneurons following brachial roots avulsion. Methods One hundred and eighty adult Sprague-Dawley female rats were randomly divided into TA9001, ECb761 and control groups. The right C 5～T 1 nerve roots were avulsed and then the introperitoneal injection of 1ml of 0.5% TA9001, 0.5% EGb761 or normal saline was given immediately and once daily to the rats, respectively. The rats were killed after survival for 4 h, 12 h 1 d,3 d,5 d,and 1 week, 2 weeks, 4 weeks and 6 weeks. The cryostat sections of C 7 segment were prepared and carried with c-jun immunocytochemistry, NADPH-d histochemistry and neutral red counter stain. Results The c-jun and nNOS gene expression was only appeared in injured motoneurons. c-jun was first appeared at 4 h, reached its maximum at 1 d, and grandually decreased till 2 weeks. NOS was first checked at 5 d, mostly at 2 weeks and decreased until 6 weeks. Avulsed motoneuron death started at 2 weeks, reached its peak at 4～6 weeks. Both TA9001 and EGb761 can cause c-jun up-regulation, nNOS down-regulation and more motoneuron survival as compared to control. Furthermore, EGb761 had more power to enhance c-jun expression than TA9901 at each time point. Conclusion It seems that nNOS is more important in motoneuron death mechanism than c-jun. Treatment of either TA9901 or EGb761 can protect the injured motoneurons following root avulsion.
Miyokardiyal kas bandı olan hastalarda nötrofil / lenfosit oranının değerlendirilmesi

Amac: Miyokardiyal kas bandi miyokart icinde seyreden epikardiyal koroner arterlerin sistolde daralmasi ile seyreden konjenital bir anomalidir. Iyi huylu olmasina ragmen onceki calismalarda proksimal kesimlerin artmis ateroskleroza egilimli oldugu gosterilmistir. Notrofil/lenfosit orani (NLO) aterosklerotik kalp hastaliklarinda kotu prognozu ongoren sistemik enflamasyonun duyarli bir belirtecidir. Biz bu calismada NLO ile miyokardiyal kas bandi arasinda bir iliski var olup olmadigini arastirmayi amacladik. Metodlar: Anjiyografik olarak tespit edilmis miyokardiyal kas bandi veya normal koroner arterleri olan 172 hasta (ortalama yas: 50.8 ± 11.5 yil, %77.3 erkek) calismaya dahil edildi. Otomatik kan sayaci kullanilarak tum hastalarin hematolojik parametreleri olculdu. Bulgular: Calisma 71 miyokardiyal kas bandi (ortalama yas: 51,4 ± 11,9 yil, %80,3 erkek) ve 101 normal koroner arterleri (ortalama yas: 50,5 ± 11,3 yil, %75.2 erkek) olan hastadan olusmaktaydi. Hemoglobin, trombosit sayisi, glukoz ve kreatinin acisindan gruplar arasinda fark saptanmadi. Kontrol grubuna gore miyokardiyal kas bandi grubunda NLO anlamli olarak daha yuksekti (2,45 ± 1,19 vs. 1,72 ± 0,48; p 1,82 miyokardiyal kas bandi varligini %70 duyarlilik ve %71 ozgullukle ongormustur (ROC egri altinda kalan alan: 0.733, 95% guvenlik araligi: 0.654-0.811, p < 0.001). Sonuc: Calismamiz miyokardiyal kas bandinin vucutta enflamatuar duzeyi gosteren yuksek NLO seviyeleri ile iliskili oldugunu gostermistir.
Dermatologic Care of the Transplant Patient: Part II

ABSTRACT The goal of this article is to build on the earlier review "Dermatologic Care of the Transplant Patient: Part I" by offering a detailed analysis of the immunosuppressive medications and management strategies used in the current approach to the transplant patient. The incidence of nonmelanoma skin cancer in organ transplant recipients increases over time as immunosuppressive therapy continues. The International Transplant Skin Cancer Collaborative provides a list of immunosuppressive medications currently used to prevent the rejection of the grafted organ in solid organ transplant recipients, which includes prednisone, cyclosporine, mycophenolate mofetil, tacrolimus, azathioprine, rapamycin, daclizumab, and muromonab. Each of these agents has many possible side effects. The longer the patient's immune system is suppressed, the greater the risk for the development of malignant skin lesions. The transplant recipient is at particular risk for developing aggressive squamous cell carcinomas. The first squamous cell carcinoma in an organ transplant recipient patient should be considered a sentinel event. The current challenge is to determine if a change to a different class of immunosuppressive medication is a better option than minimizing current medication regimens for transplant patients who develop skin cancer. Several randomized clinical trials are underway to test these theories.
1-(4-methylamino-1,2,5-thiadiazole-3-carbonyl)thiosemicarbazide.

In the title compound, C(5)H(8)N(6)OS(2), the supramolecular architecture is sustained by two N--H.O and three N--H.S hydrogen bonds, and by N.S electrostatic interactions. The hydrogen-bond network generates a sheet structure, which extends in the a and b directions and is one c-cell dimension thick. These extended sheets are then linked across inversion centres in the c direction by N.S electrostatic interactions, thus forming a three-dimensional network. The principal intermolecular dimensions include N(H). O distances of 2.8393 (17) and 3.0268 (16) A, N(H). S distances in the range 3.2896 (14)-3.5924 (16) A and N.S distances of 3.0822 (16) A.
High-Level Aminoglycoside-Resistant Enterococcal Endocarditis: A Therapeutic Challenge

AbstractEnterococci with high-level resistance to multiple aminoglycosides account for approximately one quarter of enterococcal endocarditis cases, yet there is a lack of consensus concerning optimal therapy. This issue is particularly topical as new British guidelines for the treatment of endocarditis have recently been published. We present a case of endocarditis caused by enterococci with high-level aminoglycoside resistance that was successfully treated with the counter-intuitive combination of amoxicillin and ceftriaxone. The rationale and evidence for this decision is reviewed, and other possible treatments are discussed.
8,8′‐Methylenebis(7,10‐dihydroxy‐1,3,6,6‐tetramethyl‐3,4‐dihydro‐1H‐benzo[g]isochromen‐9‐one)

In the title compound, C23H24O8, the central methyl­ene unit that links the two sets of fused rings lies on a crystallographic twofold rotation axis. The isochromene skeleton is not planar, with the pyran ring in an envelope conformation. Intra- and inter­molecular O—H⋯O hydrogen bonds and weak C—H⋯O and C—H⋯π inter­actions stabilize the crystal structure.
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

Starved to Life? Caloric restriction—reducing the calories ingested by around 30% of that of a normal, fit individual—leads to substantial increases in life span in experimental animals. In an extensive study of caloric restriction in primates, Colman et al. (p. 201) report that rhesus monkeys, which were subjected to caloric restriction as adults and followed for the last 20 years, show decreased mortality and delayed onset of age-related diseases when compared to normally fed control animals. If compliance with such a diet were not so difficult, many humans would be strongly tempted to enjoy the decreased incidence of brain degeneration, cardiovascular disease, diabetes, and cancer apparent in this population of monkeys. Age-associated death and onset of pathologies are delayed by controlled caloric restriction, thus prolonging life span. Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.
N-(2,4-Dichlorobenzylidene)-N′-phenylhydrazine

The mol­ecule of the title compound, C13H10Cl2N2, is nearly planar and adopts an E conformation about the carbon–nitro­gen double bond. The dihedral angle between the two benzene rings is 6.70 (13)°. Mol­ecules are inter­connected through weak N—H⋯π inter­ations.
cis-1-(4-Bromo­phen­yl)-6-ethyl-5-tosylperhydro­pyrrolo[3,4-b]pyrrole

In the title mol­ecule, C21H25BrN2O2S, one of the fused pyrrolidine rings adopts an envelope conformation, while the other is in a twist conformation. In the crystal structure, mol­ecules related by translation along the a axis are linked by π–π inter­actions into a chain.
Glucose metabolism during exercise in man : the role of insulin and glucagon in the regulation of hepatic glucose production and gluconeogenesis

C. Lavoie, F. Ducros, J. Bourque, H. Langelier, and J.-L. Chiasson Abstract: This study was designed to further characterize the role of insulin and glucagon in the regulation of glucose production and gluconeogenesis during a 2-h mild intensity exercise (40% VO2max) in 14 h fasted healthy male subjects. Endogenous insulin and glucagon secretions were suppressed by the infusion of somatostatin. The pancreatic hormones were replaced singly or in combination to match the hormonal concentrations observed during exercise in control subjects. Glucose turnover was determined by a tracer method using the stable isotope D-(2,3,4,6,6- 2 H)glucose. Gluconeogenesis was estimated by the simultaneous infusion of L-(1,2,3- 13 C)alanine to follow the conversion of alanine to glucose. Hepatic glucose production significantly increased from a resting rate of 12.1 ± 0.2 to 27.6 ± 1.4 μmol·kg n1 ·min n1 during exercise (p < 0.05). In the absence of glucagon, this increase in hepatic glucose production during exercise was totally abolished (p < 0.05). When insulin was made deficient, in the presence of glucagon, there was an overshoot in the increase in hepatic glucose production during exercise to 36.4 ± 1.6 μmol·kg n1 ·min n1 (p < 0.05). The normal increase in hepatic glucose output during exercise was reproduced when both insulin and glucagon were replaced. Exercise increased gluconeogenesis by 47% above the resting level (p < 0.05). When glucagon was made deficient, in the absence or presence of insulin, this increase in gluconeogenesis was totally suppressed (p < 0.05). Furthermore, glucagon replacement during exercise in the absence of insulin resulted in a further increase in gluconeogenesis to 93% above resting value (p < 0.05). From these observations, it is concluded that during prolonged mild intensity exercise in healthy subjects, the rise in glucagon is essential for the increase in hepatic glucose production and the increase in gluconeogenesis. It is also suggested that the lower level of insulin during exercise still exerts a restraining effect on glucagon-stimulated glucose production and gluconeogenesis, thus preventing hyperglycemia.