Miracle-dz/UniFAR-FTUs huggingface dataset:
A ruthenium derivative of quercetin with enhanced cholesterol-lowering activity

A ruthenium(II) p-cymene derivative of quercetin was synthesized and functionally tested for cholesterol-lowering ability via direct 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) inhibition. Ruthenium complexation dramatically increased the inhibition potency of the parent quercetin toward HMGR, with a consequent enhancement of the cholesterol-lowering effect in hepatic cells.
Counter-defense mechanisms of phytophagous insects towards plant defense.

This review focuses on the mechanisms of phytophagous insect counter-defense on plants. On one hand,insects can inhibit,escape and alter plant defense by behavior defense mechanisms,including changing feeding strategies,regulating growth rhythm and avoiding natural enemies. On the other hand, insects may confront plant defense through physiological and biochemical mechanisms,including adapting plant protease inhibitors,avoiding plant wound signals,detoxification,and inhibiting plugging reaction. At present,the hotspots are the mechanism of depression of plant wound signals and inhibition of plugging reaction. The researches on insect counter-defense will improve the understanding of the insect-plant coevolution relationship,and provide new ideas for pest management and the cultivation of resistant plants.
Phenotyping age‐sependent changes in the 5xFAD Alzheimer’s Disease Model mice (LB556)

5XFAD transgenic (Tg) mice express 5 human familial Alzheimer’s Disease (AD) gene mutations ‐ Amyloid Precursor Protein mutations from the Swedish, Florida and London families, along with 2 mutations in presenilin‐1. Their early onset brain pathology, accelerated Aβ42 amyloid deposition, age‐dependent neurodegeneration and cognitive decline, make these mice an attractive translatable AD model.
Contenido en algunos nutrientes del alga marina comestible, Monostroma undulatum, Wittrock de la costa patogónica argentina

The chemical composition of green seaweed, Monostroma undulatum, Wittrock, growing in the Southern Argentina coast, was studied. Samples were collected in Puerto Deseado, province of Santa Cruz (47 degrees 45'L.S., 65 degrees 55'L.W.), from October to December 1999 and 2000. It has been analyzed six sample during this period. Algae were washed with sea water and dried at room temperature for 24 hs. Moisture, nitrogen, lipids and ashes were determined according to AOAC; fiber (total, soluble and insoluble), according to Lahaye. After mineralization with nitric acid, sodium and potassium were determined by flame photometry, calcium by complexometric method, and phosphorus by Gomori's method. The ranges expressed per 100 g dry algae were: protein (Nx6.25): 12.89-21.85; ashes (g): 33.92-40.05; lipid (g): 0.32-1.47; total fiber (g): 14.36-19.6; digestible carbohydrates (calculated by difference) (g): 20.86-32.48; sodium (g): 7.39-13.11; potassium (g): 1.38-3.18; calcium (mg): 149-226; phosphorus (mg): 190-447; Vitamin C (mg): 159-455. These results show that this green seaweed is an important source for protein, fiber, macronutrients minerals and vitamin C, during the macroscopic period. There was an important fluctuation that must be taken into account to consider the commercial collection to use it in human nutrition.
Investigating signal transduction with genetically encoded fluorescent probes - Delivered on 22 October 2002 at the 28th FEBS Meeting in Istanbul

Ca 2 + and cAMP are ubiquitous second messengers in eukaryotes and control numerous physiological responses ranging from fertilization to cell death induction. To distinguish between these different responses, their subtle regulation in time, space and amplitude is needed. Therefore, the characterization of the signalling process requires measurement of second messengers with tools of precise localization, high dynamic range and as little disturbance of cell physiology as possible. Recently, fluorescent proteins of marine jellyfish have given rise to a set of genetically encoded biosensors which fulfil these criteria and which have already led to important new insights into the subcellular handling of Ca 2 + and cAMP. The use of these probes in combination with new microscopical methods such as two-photon microscopy now enables researchers to study second messenger signalling in intact tissues. In this review, the genetically encoded measurement probes and their origin are briefly introduced and some recent insights into the spatio-temporal complexity of both Ca 2 + and cAMP signalling obtained with these tools are discussed.
Carcass, organ and organoleptic characteristics of broilers fed yeast treated raw soya bean and full fat soya bean

Carcass, Organs andOrganoleptic Characteristics of broilers fed yeast treated raw soya bean (RSB)and full fat soya bean (FFSB) were studied using one hundred and eighty day oldchicks. Standard poultry management techniques were applied and experimenteddiets provided ad libitum. Fifteen diets consisting of various proportions ofFFSB, RSB and yeast were formulated for the starter phase (0- 28 days) andfinisher phase (29-56 days), respectively. The diets in each phase wereformulated to be isocaloric and isonitrogenous with the starter dietscontaining approximately 2900 kcal/kg ME and 23% crude protein, and thefinisher diets containing approximately 3000 kcal/kg and 20% crude protein. Thecarcass and organs studied include weights after defeathering, cut- up partswhich include thighs drumstick, shanks, wings, neck, back, breast head, andorgans such as heart, liver, spleen and gizzard. The lengths of theproventriculus, small intestine, colon and caeca were also measured. The studyshowed that RSB at the levels fed with and without yeast inclusion had nolethal effect on broiler chickens. However, higher performance may be achievedwhen RSB is fed at 25 % with 6 g/kg yeast inclusion at starter phase and at 25% without yeast or 75 % with 12 g/kg yeast inclusion. The study therefore,further maintained that inclusion of RSB with or without yeast in the diets ofbroilers can equally produce broiler with good weight comparable with feedingFFSB or conventional diets; feeding 75 % FFSB + 25 % RSB without yeastinclusion is capable of increasing the proportion of the broilers’ head andshank; RSB inclusion in broiler diets cause increase in the weight of thegizzard, pancreas as well as on the abdominal fat, and feeding FFSB and RSBwith or without east inclusion do not exert any noticeable effect on theorganoleptic ualities tenderness, flavour and in general acceptability) ofbroilers. However, RSB enhances the juiciness of broilers
Factors affecting the distribution, abundance and chick survival of the Lapwing ( Vanellus vanellus )

This thesis was conducted to investigate Lapwing Vanellus vanellus breeding ecology and its relationship with the modern agricultural landscape. Scientific research has suggested that changes in modern agricultural practices have been responsible for the declines in a suite of farmland bird species, including the Lapwing. Fieldwork was conducted over the breeding seasons of 1999 and 2000 over a range of farm locations in Shropshire and Staffordshire, with additional supplementary data obtained from a parallel study undertaken in Cambridgeshire. This research assessed the effectiveness of the ‘Lapwing Option’ (Option IB) in the pilot Arable Stewardship agrienvironment scheme. A total of 225 nests were located and monitored. There were few detectable effects of agricultural variables on clutch size, egg volume, intra-clutch egg size variation or hatching rates. Cultivation dates stipulated by Option IB avoided the peak nesting period for this population of Lapwings. At the start of the breeding season Lapwings selected a wide variety of crop types as nest sites, however, crop choice declined as the season progressed, with the majority of replacement nests on Option IB and spring crops. Lapwings were shown to select nest-sites that had a short, patchy sward structure. Nest survival was high, yet the most common causes of nest failure were predation and losses to agricultural operations. Losses on stubbles and spring cereals were primarily associated with agricultural operations. Nests that were greater than 50m distant fi*om a field boundary had a greater probability of survival than nests that were less than 50m away. Chick weight and condition were shown to be positively correlated with mean egg volume. There was no evidence that any of the measured agricultural variables had an effect on chick growth, condition or survival. Results show that chick survival was low and productivity estimates were less than that required to maintain population stability. Chicks that were known to have fledged had a better body condition index than chicks that had been predated. It was found that the variety of crop types used as foraging habitat declined as the season progressed. Option IB, set- aside and sugar beet were the latest crops that could be utilised by chicks. A variety of invertebrate taxa were found in faecal samples of chicks, with earthworms, beetles and spiders the most frequent. There was a positive relationship between the number of earthworms in the diet and chick age, chick condition and daily growth rates. Option IB appears to have a number of benefits for breeding Lapwing, although it does not address low chick survival. Further research is required to elucidate the key factors affecting chick survival and to develop management prescriptions to enhance breeding productivity.
Reforming the international financial architecture: the new political agenda

In light of recent financial crises involving Asia, Russia and Brazil, the most radical overhaul of the international financial architecture since 1945 has occurred. I argue that this development reflects a significant shift in thinking about the political prerequisites of governance in the global financial system. Most importantly, it signifies that emerging market economies must be more fully integrated into the decision-making structures of the global economy. The search for appropriate mechanisms of inclusion, however, has re-opened what have been long-settled political questions about global financial governance. These include most crucially (1) how to address the core-periphery divide within the global financial system; and (2) how to fashion an acceptable balance between public responsibility and private gain within the context of a more inclusive international decision-making structure. Resolving these political questions is now an integral part of the reform agenda, and their explicit consideration will help to determine the future effectiveness of the international financial architecture.
Donsker’s Theorem

In this paper we provide a detailed proof of Donsker’s Theorem, including a review of the majority of the results on which the theorem is based, and we design algorithms that provide experimental evidence for the Classical Central Limit Theorem and that allow us to observe the effects of Donsker’s Theorem. Acknowledgments. I would like to thank the University of Ottawa Work Study Program for making this work term possible and Professor Raluca Balan for accepting to hire me as her assistant for the summer.
RESEARCHING INNOVATION STRATEGIES OF FOREIGN INVESTMENT ENTERPRISES: THE CASE OF CROATIA

Foreign investment enterprises, characterised by MNE ownership are differentiated by the desired strategic goals, executed through their business activities. In general, these enterprises can be seeking to access the international (global) market, increase efficiency and production flexibility of its business group, exploit low acquisition price of state-owned companies in comparison to the investment risk (Bitzenis and Marangos, 2008), delocate/relocate the production activities towards low-wage countries as well as tapping into localised tacit knowledge (cf. Costa and Filippov, 2008). In business practice, strategic goals have been achieved simultaneously with the existence of a goals hierarchy, hence one goal (e.g. increase efficiency within MNE group) presents a priority in comparison to other goals. In the context of achieving strategic goals innovation activities within firm's strategy frequently presents a crucial activity.
EXPERIMENTAL INVESTIGATION AND PATH DEVIATION ANALYSIS OF SQUARE STRUCTURED OMNI DIRECTIONAL MOBILE ROBOT

This paper describes a four wheeled, Square Structured Omni Directional Mobile Robot (SSODMR). The design, different motion analysis and prototype of SSODMR is fabricated. In this research, the Omni Directional wheel consists of eight rollers in a single row, which has been arranged over the circumference of the wheel. This SSODMR can move in all eight directions without steering its wheel. In addition, it can also make clockwise and anti-clockwise rotations. It consists of four Omni Directional Wheels, fixed with 12 V, 30 rpm D.C motors. A Square structured chassis holds the motors and they are manually controlled by DPDT switches. The motion analysis has been practically done on a cement floor. The deviation from the desired path has been measured and hence the mobility of SSODMR has been practically analysed.
To elucidate the Epstein-Barr virus replisome

Epstein - Barr virus (EBV) is a member of the γ-herpesvirus subfamily of Herpesviridae. EBV is a double stranded DNA virus infecting humans causing a variety of disease from asymptomatic infection to association with certain tumours including Burkitts lymphoma, Hodgkin’s disease and nasopharyngeal carcinoma. EBV encodes an immediate-early protein called Zta (BZLF1, EB1, ZEBRA), which is an important transcription factor and replication factor direct in disrupting latency. EBV encodes viral proteins that assemble as a replisome at the viral lytic origin recognition site (Ori-Lyt). Zta binds Ori-Lyt and it is unclear how Zta interacts and recruits the complex to the site of DNA replication, while coordinating and recruiting host factors. After a mutation to three alanines (ZtaAAA) data implicates that the extreme C-terminus of Zta is essential for replication. The question posed is how does Zta assemble the replisome? Identification of the lytic changes that contribute to lytic replication, including cellular components that may contribute to EBV replication is attempted. Transfected control, Zta and ZtaAAA in HEK293-BZLF1-KO cells was compared. Size exclusion chromatography identified a higher molecular weight complex containing Zta during viral replication. SILAC (Stable isotope labelling by amino acids in cell culture) coupled to proteomics analysis identified the elution fraction composition. An interpretation of these cellular components in the context of lytic replication is explored. Identification of interactions of Zta with cellular proteins was attempted by SILAC histidine tagged Zta with pull down assay. Quantitative data was returned and a confirmation of interactions was attempted. A global proteomics approach was also performed. An enrichment method to isolate SILAC labeled Burkitts Lymphoma cells undergoing EBV lytic replication was coupled to mass spectrometry analysis to identify changes in host and viral proteins. Overall, cellular targets that may interact with Zta are to be confirmed. The global proteomics study recognized for the first time by proteomic analysis the identification of three EBV lytic replication cycle protein
Surface characteristics of particleboard produced from hydro-thermally treated wheat stalks

Surface characteristics were studied for particleboards produced from hydro-thermally treated (HTT) and non-treated (NT) wheat stalk (WS). Wood and wheat stalk particles were used as experimental materials. The wheat stalk particles were subjected to HTT at a temperature of 180 °C for 8 minutes in a steam explosion machine. HTT and NT WS particles were added at 10%, 20%, 30%, and 40% to the wood particles. The surface roughness and wettability of the produced panels were determined. The roughness measurements, average roughness (Ra), maximum roughness (Rmax), and mean peak-to-valley height (Rz) were performed using a ﬁne stylus tracing technique. The wetting behavior of the panels was characterized by the contact angle method (goniometer technique). The contact angle (CA) measurements were obtained by using a KSV Cam-101 Scientiﬁc Instrument connected with a digital camera and computer system. Statistical analyses showed signiﬁcant differences in the surface roughness and wettability of the particleboards following hydro-thermal modiﬁcation. The addition of WS to the panels significantly decreased the roughness values. However, all of the HTT groups exhibited higher roughness compared to NT groups. The CA values decreased when the WS content increased. The wettability of the particleboard containing HTT WS particles was improved.
A lkaline Cellulase Production by Penicillium m allochii LMB - HP37 Isolated from Soils of a Peruvian Rainforest

Alkaline cellulases are demanded by the textile industry for several purposes but commercial preparations showing activity at alkaline conditions are very scarce. Aim: To characterize a Penicillium strain isolated form soils of a Peruvian rainforest showing alkaline cellulase activity that may be useful for the textile industry. Methodology: The molecular identification was based on the DNA sequence of its ITS region using ITS1 and ITS4 primers after PCR amplification. Cellulase production was evaluated in shaken flasks by using either lactose or microcrystalline cellulose. Total cellulase (as FPA) and endoglucanase activities wer e evaluated by the standard methods at several pH levels. Also, the Original Research Article
The Impact of Personality Types of Tax officials on Tax Identification and Collection

*Corresponding Author Abstract: This research aimed to investigate the effect of personality types of tax officials on tax identification and collection in Chaharmahal and Bakhtiari Province. During the contemporary era, the tax system in Iran has taken effective steps in pursuit of the policy of tax conversion as the main important revenue source for the government. In spite of effective efforts in this regard, the Iranian tax system has faced with several challenges and damages that should be addressed. In this research, the effects of personality types of tax officials on tax identification and collection in the Tax Administration Office of Chaharmahal and Bakhtiari Provincein are investigated in 2017. The results of this research showed that personality types are significantly related to the tax collection and are in direct relation with regard to the positive beta coefficient (ββ). Therefore, it can be concluded that the kind of personality types of tax officials is related to the recognition, collection, and non-collection of taxes.
Nudging in Public Policy and Public Management: A scoping review of the literature

As the topic of behavioural economics and nudging made its way to the public sector and into public policy, the academic literature on the topic grew simultaneously (Bogliancino et al., 2016). The question now, almost a decade after Thaler and Sunstein’s seminal publication “Nudge: improving decisions about health, wealth, and happiness” (2008), is how far the research on nudging as a policy tool has come. Which policy areas are covered by research on the effectiveness and usage of nudging? What conceptual lenses are used in this research? Which methods are applied? What heuristics are most commonly focused on whilst applying and studying nudges? Which goals are nudges supposed to attain? What types of outcomes of nudging can be discerned from the literature? A scoping review technique is applied in this paper to find answers to these and other questions. Such a scoping study is defined as a “form of knowledge synthesis that addresses an exploratory research question aimed at mapping key concepts, types of evidence, and gaps in research [. ] by systematically searching, selecting and synthesizing existing knowledge. ” (Colquhoun et al., 2014, p. 1294) Through this review of over 300 articles from the nudging literature, this paper informs researchers and practitioners about the current state of the literature around nudging as a novel policy tool. *Presenting Author KU Leuven Public Governance Institute ellen.fobe@kuleuven.be Parkstraat 45, Bus 3609 B-3000 Leuven, Belgium
4 An Ultra-Low Phase Noise Class-F 2 CMOS Oscillator

In this chapter, we discuss and analyze a class of operation of an RF oscillator that further minimizes its phase noise. The main idea is to enforce a clipped voltage waveform around the LC tank by increasing the second harmonic of fundamental oscillation voltage through an additional impedance peak, thus giving rise to a class-F2 operation. As a result, the noise contribution of the tail current transistor on the total phase noise can be significantly decreased without sacrificing the oscillator’s voltage and current efficiencies. Furthermore, its special impulse sensitivity function (ISF) reduces the phase sensitivity to thermal circuit noise. The prototype of the class-F2 oscillator is implemented in standard TSMC 65 nm CMOS occupying 0.2 mm2. It draws 32–38 mA from 1.3-V supply. Its tuning range is 19% covering 7.2–8.8 GHz. It exhibits phase noise of −139 dBc/Hz at 3-MHz offset from 8.7-GHz carrier, translated to an average figure of merit of 191 dBc/Hz with less than 2-dB variation across the tuning range.
Various Recursive Mixed L2-Linfty Algorithms for Linear-in-the-Parameters Models

- In this paper, various Recursive Mixed L2-Linfty (RML) learning algorithms are developed by choosing different forgetting factor matrix function  (  ) for Linear-in-the-Parameters (LIP) models, including Projection, Recursive Mixed L2-Linfty, Recursive Mixed Mean L2-Linfty,  - weighted Mixed L2-Linfty, instantaneous RML, and Batch RML algorithms. A few models are given to apply the proposed RML algorithms for system identification, and some simulations are carried out to show the algorithms’ efficiency and effectiveness.
Dual mechanistic function of MDSC subsets in melanoma resistance.

8590 Background: Myeloid-derived suppressor cells (MDSC) accumulate in tumor-bearing hosts, suppress T-cell function and promote tumor-driven angiogenesis. Melanoma represents a resistant tumor type that is nevertheless highly immunogenic. Angiogenesis, closely linked to ulceration in primary tumors, plays a particularly important role in melanoma progression. The role of MDSC in promoting immune suppression and angiogenesis in melanoma is not fully understood. Methods: T-cell function (IFNγ production), MDSC subset frequencies (CD15+ neutrophilic, n-MDSC, CD14+ monocytic, m-MDSC, and CD15-CD14- immature, i-MDSC) and MDSC production of proangiogenic factors were measured in stage III/IV melanoma patients. n-MDSC and m-MDSC were induced from healthy donor blood by melanoma conditioned media (MCM). Induced n-MDSC and m-MDSC were compared in their ability to impact growth and vascularity in melanoma xenografts. Results: T- cells derived from melanoma patients were significantly deficient in Type-1 function c.