Miracle-dz/UniFAR-FTUs huggingface dataset:
Aktivitas Inhibitor α-Amilase Ekstrak Etanol Tanaman Brotowali (Tinospora crispa L.)

Brotowali plant (Tinospora crispa L.) is a traditional Indonesian medicinal plant which has many benefits including for diabetes drugs. Diabetes mellitus (DM) is a metabolic abnormality caused by an increase in blood sugar levels. The purpose of this study was to determine the activity of α-amylase inhibitors of Brotowali (T. crispa L.) ethanol extract of plants. Extraction is done by maceration followed by evaporation. The extract obtained was tested for α-amylase inhibitor activity. The α-amylase inhibition test is based on the breakdown of starch substrates into maltose and glucose which is then determined by spectrophotometer after administration of DNS. Tests are carried out on controls and samples. As a substrate is 0.5% starch solution in 100 ml of sterile aquades. The reaction mixture was incubated 25 ° C for 10 minutes. The reaction is stopped by adding 2 ml of 3,5-dinitrosalicylic acid (DNS). All the mixed solutions are then heated to 100 ° C for 5 minutes and allowed to cool. The change in color of the solution is then measured for its absorbance at a wavelength of 540 nm. As a comparison used a control test that did not use extract samples. The results of α-amylase inhibitor activity test showed that ethanol extract with a concentration of 1000 μg / mL had the highest inhibitory activity value of 95.06% compared to extract concentration of 500 μg / mL, 250 μg / mL, 125 μg / mL and 62.5 μg / mL. The results of testing the effect of substrate concentration showed that 0.5% starch concentration had the highest inhibitory value of 9.52% compared to 2%, 1% and 0.25% concentrations
Feline immunodeficiency virus infection

Uzrocnik imunodeficijencije macaka je RNA virus svrstan u rod Lentivirus porodice Retroviridae. Virus nije osobito infekciozan. Prenosi se prvenstveno ugrizom tijekom borbi mužjaka. Prijenos spolnim putem, dijaplacentarno ili mlijekom te njegom mladunceta je moguc ali nije uobicajen. Zaraza uzrokovana virusom imunodeficijencije razvija se u 5 stadija: a) akutna infekcija ; b) asimptomatska faza ; c) rana simptomatska faza ; d) klinicki uznapredovala simptomatska faza ; e) kasna simptomatska faza. Akutna infekcija najcesce se ocituje kao benigna virusna zaraza i vecinom prolazi nezapaženo. Otecenje limfnih cvorova može se naci tijekom 2 do 9 mjeseci i pojavljuje se u svih inficiranih životinja. Asimptomatska faza infekcije posljedica je domacinovog imunosnog odgovora kojim je vecina virusnih cestica eliminirana. Ne javljaju se klinicki znakovi bolesti. Simptomatska faza ocituje se limfadenopatijom, povratnom groznicom, gubitkom težine, gingivitisom/stomatitisom, kronicnim disnim, crijevnim i kožnim infekcijama te u manjem broju slucajeva oftalmoloskim, neuroloskim i neoplastickim poremecajima. Dijagnoza se može postaviti dokazom protutijela imunoenzimnim testom ili metodom imunoflorescencije Pozitivan nalaz u klinicki zdravih macaka, poglavito ako potjecu iz skupine niskog rizika, treba potvrditi Western blot metodom. Djelotvornog protuvirusnog lijeka nema, provodi se simptomatska terapija. Zastitno cjepivo za sada ne postoji. Nema dokaza da virus imunodeficijencije macaka predstavlja opasnost za zdravlje ljudi.
Des interfaces reelles metal/MgO(001) au transport dans les jonctions tunnel epitaxiees

Cette these presente une etude des interfaces metal de transition ferromagnetique/oxyde et leur importance dans les mecanismes de transport tunnel polarise en spin. Le travail a porte sur des bicouches ultraminces NiMnSb/MgO(001), Fe/ MgO(001), Co/ MgO(001) et Mn/ MgO(001) elaborees par epitaxie par jets moleculaires. L'originalite de ce travail reside dans l'etude approfondie des proprietes electroniques du materiau magnetique en contact avec la barriere d'oxyde : hybridation, polarisation et magnetisme a l'interface ont ete etudies en utilisant les techniques de laboratoire ainsi que le rayonnement synchrotron. Parallelement, l'etude des effets magnetoresistifs dans des jonctions tunnel totalement epitaxiees Fe/MgO/Fe(001) a apporte des preuves du filtrage par la barriere MgO des ondes de Bloch en fonction de leur symetrie. Enfin, nous avons mis en evidence l'influence de la qualite structurale et chimique de l'interface Fe/MgO et des electrodes sur ces mecanismes.
Disentangling Religiosity: The Impact of Religious Motivators on Business Ethics (A Mixed-Methods Study)

Empirical studies confirm that there is a positive effect from a believer’s religiosity to business ethics; this effect is presently called the spillover effect. The problem with those studies is that ‘religiosity’ is poorly operationalized as a monolithic construct, which does not result in substantial meaningful findings. The present paper uses a more sophisticated approach through conceptualizing religiosity as a multidimensional construct consisting of five dimensions: intellect, ideology, experience, private practice, and public practice. The goal is to find ‘religious motivators’ (or ‘religious motivating factors’) that constitute the spillover effect, so to discover factors of individual religiosity that explain the relationships. There were two empirical studies with different methodologies applied: a quantitative study performed on two large data sets and a qualitative study with expert interviews. It was found that the spillover effect is a complex phenomenon with intertwined relationships, consisting of many indirect and mediating effects. The analysis showed that the influence of religiosity on business ethics can be profound but is mostly present as an indirect and not a direct effect. It is dependent on the level of integration of one’s faith into a subject’s personality and the effect can be positive as well as negative, depending on the contextualization of the religious motivator. However, the relationship is usually positive. This means that higher levels of religiosity positively correlate with the strife to behave ethically at the workplace. The main result is a conceptual model where 30 religious motivators are displayed, each consisting of a set of subcategories. The motivating factors are clustered to seven meta-categories, which are: religious cosmos, relationship with God, duties & rights, lifestyle & devotions, rationality & reality, social environment, and destination. Some important motivators are: view of God (God image), responsibility (being caretakers), guidelines, attitudes towards life, prayer life, basis of values, community, God’s plan, and soteriology. Nevertheless, there is still much potential for future research.
Aerial and Terrestrial Photogrammetric Point Cloud Fusion for Intensive Forest Monitoring

Remote sensing methods for forest monitoring are evolving rapidly thanks to recent advances in Unmanned Aerial Vehicle technology and digital photogrammetry. Photogrammetric point clouds allow the non-destructive derivation of individual tree parameters at a low cost. The fusion of aerial and terrestrial photogrammetry for creating full-tree point clouds is of utility for forest research, as tree volume could be assessed more economically and efficiently than by traditional methods. However, this is challenging to implement due to difficulties with co-registration and issues of occlusion. This study explores the possibility of using spherical targets typically used for Terrestrial Laser Scanning to accomplish the co-registration of UAV-based and terrestrial photogrammetric datasets. Results show a full-tree point cloud derived from UAV oblique imagery in combination with terrestrial imagery. Despite issues of noise produced from the sky in terrestrial imagery, the methodology is promising for aerial and terrestrial point cloud fusion.
Evolutionary Algorithms: Multimodal Problems and Spatial Distribution

Over the last few decades, optimization problems have gained special attention in the world of computing, mainly because thanks to them, complex problems, which could only be addressed through approaches, now can be solved. In the wild, biodiversity is manifested by subtle differences in the individuals genetic code and consequently in the evolution of species. This approach is intended to apply to solving optimization problems through multimodal evolutionary algorithms. Standard evolutionary algorithms are not able to find more than a local optimum in the case of multimodal functions due to stochastic errors are committed (an individual randomly move one class to another) and that the population has a finite size (finite diversity). For this reason, in this work, a detailed study of the techniques of solving multimodal problems by using spatial evolutionary algorithms is done. In addition, the design details of new mechanisms for spatial evolutionary algorithms that allow us to reallocate the space of solutions are introduced. Thus, we will be able to deal with the resolution of complex problems with multiple local or global solutions.
The process of translation, adaptation, and question of feminism in Luo Guanzhong’s Romance of the Three Kingdoms

As one of the Four Great Classic Novels of Chinese literature, Romance of the Three Kingdoms found its way to the constellation of World Literature via translation and being adapted into the movie Red Cliff (2008) and famous video games series Dynasty Warriors (1997-now). This process further made the story of the Three Kingdom is widely known as many cinemagoers and gamers can associate themselves with the story in the form that they adore. Both processes, however, have disadvantages as they erase the Chinese cultural elements that are demonstrated in the novel. This novel is also heavily riddled with patriarchal paradigm that makes scholars consider Romance of the Three Kingdoms “masculine novel” by portraying women in a very weak position in Chinese society. This paper would try to dissect the issues of translation and women portrayal in detail by analyzing the translated work of Romance of the Three Kingdoms to see what cultural aspect that is disappear as a result of translation and dissecting the dismissive and derogative portrayal of several women characters in the novel. Keywords : Luo Guanzhong, Romance of the Three Kingdoms, Feminism, World Literature
Variantkey: A Reversible Numerical Representation of Human Genetic Variants

Human genetic variants are usually represented by four values with variable length: chromosome, position, reference and alternate alleles. There is no guarantee that these components are represented in a consistent way across different data sources, and processing variant-based data can be inefficient because four different comparison operations are needed for each variant, three of which are string comparisons. Working with strings, in contrast to numbers, poses extra challenges on computer memory allocation and data-representation. Existing variant identifiers do not typically represent every possible variant we may be interested in, nor they are directly reversible. To overcome these limitations, VariantKey, a novel reversible numerical encoding schema for human genetic variants, is presented here alongside a multi-language open-source software implementation (http://github.com/genomicspls/variantkey). VariantKey represents variants as single 64 bit numeric entities, while preserving the ability to be searched and sorted by chromosome and position. The individual components of short variants can be directly read back from the VariantKey, while long variants are supported with a fast lookup table.
Host species identity in annual Brassicaceae has a limited effect on the assembly of root-endophytic fungal communities

ABSTRACT Background Establishing the contribution of host plant genotype to the assembly of root-associated microbial communities can be challenging, since multiple ecological factors may confound the effects purely due to the host, and plant species often do not occur sympatrically. Aims We aimed to measure the relative importance of host plant species on driving the assembly of natural root-endophytic fungal communities, as compared to other habitat conditions that depend on the local environment. Methods Species of annual wild Brassicaceae and the cultivated Brassica napus were collected in two separate locations, where they grew in close proximity. Arrhentherum elatius (Poaceae) was also collected in both sites and used as outgroup. The root-endophytic fungal communities of these plants were characterised using Illumina MiSeq amplicon sequencing and cultivation, and compared between locations and hosts. Results Plant family and sampling location were the factors driving most variation in fungal communities, affecting both community composition and the proportion of cultivable fungi. Whether Brassicaceae were wild or domesticated had little effect on endophytic communities, although its contribution increased when cultivable fungi were considered. No strong specificity of endophytes towards hosts was found, because a core mycobiome was shared by different species. Conclusions Plant species is a limited predictor of the structure and composition of fungal endophytic communities in roots of annual Brassicaceae, as compared to geographic location. However, the host effect on endophytic assemblages increases with phylogenetic distance between hosts.
New robust control schemes linking linear and sliding mode approaches

This work deals with the design of control laws for nonlinear, uncertain and perturbed systems based on sliding mode control and linear state feedback. Sliding mode control is known for its robustness versus perturbations and uncertainties as well as high accuracy tracking; however, it is high energy consuming. The linear state feedback is known to be a smooth control and low energy consuming, but it is highly sensitive to perturbations and uncertainties. The first objective of this thesis is the development of control laws that have the advantages of both sliding mode control (robustness and accuracy) and linear state feedback (low energy consumption). The second objective is to show the applicability of the proposed methods to real physical systems, notably the LS2N electropneumatic bench. Applications are also made on a wind system physical systems, notably the LS2N electropneumatic bench. Applications are also made on a wind system.
GC–MS Profiling and Antimalarial Activity of Khaya grandifoliola on Plasmodium berghei–infected mice

ABSTRACT This study evaluated the antiplasmodial activity and chemical constituents of ethanolic leaf extract of Khaya grandifoliola on mice infected with Plasmodium berghei. Twenty-five mice of both sexes (~30–40 g) were divided into five groups of five mice each. Group 1 (normal control) was untreated and uninfected. Groups 2–5 were intraperitoneally inoculated with 2.5 × 107 P. berghei, while group 2 (disease control [DC]) was untreated-infected group, group 3 (standard drug) received a standard drug, artesunate (50 mg kg−1 b.w.) for 4 consecutive days; groups 4 (LEKG50) and 5 (LEKG100) received ethanolic leaf extracts of K. grandifoliola at 50 mg kg−1 b.w. and 100 mg kg−1 b.w. , respectively, after establishment of infection. The LD50 was 4,207.5 mg kg−1 b.w. The results showed a reduction in the mean parasite load of LEKG50 and LEKG100 when compared with DC at day 6 postinfection and beyond. Both LEKG50 and LEKG100 recovered in packed cell volume after an initial drop. There were variable changes in the level of lymphocytes, monocytes, eosinophils, and neutrophils in both LEKG50 and LEKG100 throughout the study period. Sixteen constituents were identified by gas chromatography/mass spectrometry analysis, and oleic acid (33.83%) was most prominent.
Collaborative Mobile Cable-Driven Parallel Robots

This thesis presents a novel concept of Mobile Cable - Driven Parallel Robots (MCDPRs) as a new robotic system. MCDPR is composed of a classical C able - D riven P a rallel R obot (CDPR) mounted on multiple mobile bases. MCDPRs combines the autonomy of mobile robots with the advantages of CDPRs, namely, large workspace, high payload - to - weight ratio, low end - effector inertia, deployability and reconfigurability. Moreover , MCDPRs presents a new technical innovation that could help to bring more flexibility and versatility with respect to existing industrial robotic solutions. Two MCDPRs prototypes named FASTKIT and MoPICK have been developed during the course of this the sis. FASTKIT is composed of two mobile bases carrying a six degrees - of - freedom moving - platform, pulled by eight cables , with a goal to provide a low cost and versatile robotic solution for logistics. MoPICK is composed of a three degrees - of - freedom movi ng - platform pulled by four cables mounted on four mobile bases. The targeted applications of MoPICK are mobile tasks in a constrained environment, for example, a workshop or logistic operations in a warehouse. The contributions of this thesis are as follow s. Firstly, all the necessary conditions are studied that required to achieve the static equilibrium of a MCDPR . These conditions are used to develop a Tension Distribution Algorithm for the real time control of the MCDRP cables. The equilibrium conditions are also used to investigate the Wrench - Feasible - Workspace of MCDPRs. Afterwards, the kinematic performance and twist capabilities of the MCDPRs are investigated. Finally, the last part of the thesis presents multiple path planning strategies for MCDPRs i n order to reconfigure the CDPR’s geometric architecture for performing the desired task.
La kinase Aurora A comme nouvelle cible des agents chimiothérapeutiques Application aux traitements des cancers colorectaux

L'entree des cellules en mitose se caracterise par l'augmentation d'expression de la kinase Aurora A. Nous avons caracterise l'effet du sn38, metabolite actif de l'irinotecan utilise dans le traitement du cancer colorectal sur l'expression de cette kinase. En absence de traitement, le facteur de transcription c-myc se lie au promoteur d'Aurora A et l'active. Cependant, le traitement des cellules avec du sn38 induit l'inhibition de c-myc et son absence du promoteur d'Aurora A s'accompagnant de l'induction du processus de senescence. Nous avons egalement etudie l'effet de l'oncogene Ras sur la kinase Aurora A. Cet oncogene induit une diminution d'expression d'Aurora A par une modulation de l'activite des cofacteurs transcriptionnels de c-myc. En resume, nos resultats indiquent qu' Aurora A est une cible des traitements de chimiotherapie et des mecanismes de controles oncogeniques. Le blocage de son expression constitue certainement une protection contre le developpement tumoral.
Productivity of rabbits and balance of selenium in their body by feeding different doses of selenium

Productivity of rabbits and balance of selenium in their body by feeding different doses of selenium /T. L. Syvyk, L.S. Dyachenko, O. M. Tytariova //Bulgarian Journal of Agricultural Science . - 2018 . - 24 (No 3) . -P. 480–483
The effect of electrical discharge treatment of milk whey on partial conversion of lactose into lactobionic acid

The article considers the scientific aspects of probable partial transformation of lactose into lactobionic acid due to the electrical discharge dispersion of magnesium and manganese conductive granules in milk whey – a traditional lactose-containing raw material. The object of this study was milk whey, defatted and with casein dust particles removed, which was treated in a discharge chamber with a conductive layer of magnesium and/or manganese granules at (20±2)°С with 120–180 s of exposure. A UPLC-MS/MS analysis of milk whey was carried out using a TSQ Vantage chromatograph-mass spectrometer (ThermoFinnigan, USA) connected to a Dionex Ultimate 3000 liquid chromatograph. The changes have been studied taking place in pH and redox potential of milk whey after electrical discharge treatment, as compared to the original whey. It has been established that electrical discharge treatment with 180 s of exposure increases the Mg content in milk whey by approximately 4 times, and increases the Mn content by 3.5 times. The dispersed metal particles are found in nano- (about 30 nm) and microscale (100 nm to 10 µm). The UPLC-MS/MS analysis of the test samples of whey that underwent electrical discharge treatment allowed identifying a chromatographic peak [M–H]–=357 m/z related to lactobionic acid. The derivative lactose content increased by 2 times in the whey samples treated for 180 s in a reaction chamber with a conductive layer of Mg between the corresponding electrodes, as compared to the original whey, and by 4 times in the samples subsequently treated in the reaction chambers with a layer of Mg and Mn granules between the corresponding electrodes, with 120 s of exposure in each chamber. The way has been presented of solving the problem of complex, economically practical and environmentally safe processing of milk whey with the prospect of obtaining lactobionic acid, a biologically valuable derivative of lactose.
The utility of stem cells for neural regeneration

The use of stem cells in biomedical research is an extremely active area of science. This is because they provide tools that can be used both in vivo and vitro to either replace cells lost in degenerative processes, or to model such diseases to elucidate their underlying mechanisms. This review aims to discuss the use of stem cells in terms of providing regeneration within the nervous system, which is particularly important as neurons of the central nervous system lack the ability to inherently regenerate and repair lost connections. As populations are ageing, incidence of neurodegenerative diseases are increasing, highlighting the need to better understand the regenerative capacity and many uses of stem cells in this field.