Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of clonal and regenerative perivascular stem cells in human endometrium

Decidualization denotes the transformation of endometrial stromal cells into specialised secretory decidual cells, a process indispensable for pregnancy. Decidualization of the human endometrium is not dependent on an implanting embryo but initiated during the mid-luteal phase of the cycle by elevated progesterone levels and local paracrine signals. Consequently, decidualization is a reiterative process directly linked to menstrual repair and rapid oestrogen-dependent growth. The extraordinary regenerative ability of the endometrium depends on endometrial mesenchymal stem cells (eMSCs) with inexhaustible self-renewing and differentiation capacity. Cyclic regeneration and rapid proliferation also render the stroma intrinsically heterogeneous, harbouring not only eMSCs but also endometrial transit amplifying (eTAs), mature, and senescent fibroblast subpopulations. Several lines of evidence presented in this thesis demonstrated that imbalance in these subpopulations is associated with reproductive failure. Quantification of clonal (eMSCs/eTAs) cells in mid-luteal biopsies obtained in consecutive cycles revealed increased levels in the 2nd biopsy obtained from miscarriage but not infertile patients, indicating that the tissue response to injury (i.e. the 1st biopsy) differs between patient groups. Further, in-depth characterization of primary stromal cell cultures prior to in vitro fertilisation (IVF) treatment showed that disordered temporal changes in the secretome of decidualizing cultures are associated with subsequent implantation failure. Additional characterization of perivascular eMSCs, which drive endometrial regeneration, highlighted the unique properties of these cells in terms of gene expression, metabolism, clonogenic and angiogenic potential. Importantly, eMSCs also formed 3D structures that resemble the uterine mucosa when cultured in Matrigel. These novel organoids termed endometrial regenerative bodies (ERBs), epithelialize when co-cultured and decidualize in response to differentiation cues. In sum, I provided evidence that dyshomeostasis between stromal subpopulations, which may be caused by eMSCs deficiency or dysfunction, precedes reproductive failure. Further, the ability of eMSCs to form ERBs provides a powerful new tool to study physiological and pathological implantation events in vitro.
Future Holiday Climate Index (HCI) Performances of Urban and Beach Destinations in the Mediterranean

<p>Tourism is a major socioeconomic contributor to established and emerging destinations in the Mediterranean region. Recent studies introducing the Holiday Climate Index (HCI) highlight the significance of climate as a factor in sustaining the competitiveness of coastal and urban destinations. The aim of this study is to assess the future HCI performances of urban and beach destinations in the greater Mediterranean region. For this purpose, HCI scores for the reference (1971-2000) and future (2021-2050, 2070-2099) periods were computed with the use of two latest greenhouse gas concentration trajectories, RCP 4.5 and 8.5, based on the Middle East North Africa (MENA) Coordinated Regional Downscaling Experiment (CORDEX) domain and data. The outputs were adjusted to a 500 m resolution via the use of lapse rate corrections that extrapolate the climate model topography against a resampled digital elevation model. All periodic results were seasonally aggregated and visualized on a (web) geographical information system (GIS). The web version of the GIS also allowed for a basic climate service where any user can search her/his place of interest overlaid with index ratings. Exposure levels are revealed at the macro scale while sensitivity is discussed through a validation of the climatic outputs against visitation data for one of Mediterranean's leading destinations, Antalya. HCI:Urban results showed that Canary Islands hold suitable conditions for tourism during almost all four seasons and all five periods which will have certain implications when other core Mediterranean competitors lose their relative climatic attractiveness. HCI:Beach results for the summer season showed that Las Canteras, Alicate, Pampelonne, Myrtos, Golden Sands and Edremit all pose Very Good to Excellent conditions without any Humidex risks for the extreme future scenario (2070-2099 RCP8.5). <br>Much detailed outputs of the study can be viewed from the web service at: <br>http://climatechange.boun. edu.tr/en/holiday-climatology-of-the-mediterranean/</p><p>. </p>
Analgesic Efficacy of Corticosteroids Used as Intracanal Solutions to Control Inter Appointment Pain during Root Canal Treatment – A Systematic Review

Patients often associate endodontic treatment with pain. Inter appointment pain is common during endodontic treatment and is due to acute inflammation of the apical periodontal ligament space. Till date, several agents have been employed to manage inter appointment pain by administering them through different routes. All the agents for pain control were administered orally in the past. In order to bypass the unwanted side effects and achieve immediate and effective pain control, local administration was followed by intracanal administration. This systematic review analyzes the effect of intracanal delivery of various steroid solutions and their effectiveness in pain management. A search was performed in electronic database (i.e. Pubmed Central, Google and Hand Search) till August 2019.All in vivo studies that used intracanal corticosteroids for controlling inter appointment pain during endodontic treatment were selected.The outcome measure was to evaluate the reduction of pain in the inter appointment period after intracanal drug delivery. Systematic Review Pai and Nivedhitha; JPRI, 32(16): 54-62, 2020; Article no.JPRI. 59699 55 Since all the studies included for this review showed high risk of bias, no conclusion could be drawn on intracanal use of corticosteroid solutions for analgesia. Further studies have to be conducted with a proper design, standardization of the drug and appropriate statistical analysis to obtain accurate results.
Miscanthus: European experience with a novel energy crop

Miscanthus is a perennial, highly productive C4 grass, introduced from eastern Asia, which is included in the group of co-called "bioenergetic crops". Miscanthus represents a plant species convenient for intensive culture, which by its biomass may enable a successful substitution of actual energy sources by new, renewable sources, a plant which will decrease the emission of the "greenhouse gas" - CО2. This paper presents a review of the most important results and experiences in miscanthus culture in Europe in the last 15 years, as a prerequisite for conducting appropriate investigation of successful establishment and economical growing in culture of this plant species in Serbia.
Potential impact of the COVID-19 pandemic on mental health outcomes in societies with economic and political instability: case of Lebanon

Purpose Coronavirus disease 2019 (COVID-19) is an infectious disease that has rapidly spread to most cities in the world since December 2019 causing a rise in global mortality and adverse effects on mental health. This paper aims to examine the potential implications of the pandemic for mental health in societies with economic and political instability, focusing on Lebanon. Design/methodology/approach Previous empirical research into mental health and COVID-19 was examined in relation to the Lebanese context. Findings There is a risk of poor mental health in Lebanon owing to the deleterious effects of military conflict and political instability over several decades. More recently, the country is also experiencing the worst economic crisis in its history with unprecedented rates of unemployment, inflation, poverty, and devaluation of the national currency. It is suggested that the lockdown measures may be depriving the Lebanese people of effective coping strategies, such as group memberships (e.g., religion), social support and community involvement, during the COVID-19 outbreak. This in turn may lead to the deployment of maladaptive coping strategies in the population. Practical implications Mental health services are still in their formative phases in Lebanon and mostly run by civil society organizations. There is an urgent need for a national action plan to respond to the potential mental health burden and use of maladaptive coping strategies which may arise in the aftermath of COVID-19. Originality/value This paper provides a novel analysis of mental health in Lebanese society through the lens of social, political, economic and psychological factors.
Acute Coronary Syndrome in Octogenerians: Management Perspectives

Current guidelines for acute coronary syndrome are derived from the data in randomized clinical trials and metanalysis conducted in patients. These patients are generally of younger age. The data of acute coronary syndrome in octogenarians is mainly derived from registries. This mid and long-term data regarding medical therapy or interventions in octogenarians is low in number with smaller subsets of patients. Most of the physicians are reluctant to use the same guidelines in these elderly patients due to increased chances of complications. This article reviews the available data and literature in acute coronary syndrome in octogenarians and provides management perspectives for these elderly patients.
Model checking the DNS under DNS cache-poisoning attacks using SPIN

Domain name system (DNS) security has garnered substantial interest due to DNS cache-poisoning attacks. In this article, a model checking method is employed to verify the security of the DNS protocol, especially when it is under DNS cache-poisoning attacks. The DNS protocol is first translated into a simpler model that preserves all the attack behaviour to be verified. Extended finite state machine models are given and represented in PROMELA which can be identified by SPIN; and then the whole process of model checking is proposed. The initial results on verification of the DNS under DNS cache-poisoning attacks using SPIN are also proposed. From the experimental results it can be seen that the security of DNS should be carefully considered.
Defining The Concepts “Competence” And “Communicative Competence”

Competence is defined as communicative language ability a concept comprised of knowledge or competence and capacity for appropriate use of knowledge in a contextual communicative language use. In this article, the concepts “competence” and “communicative competence” are defined and the models of communicative competence are discussed in language teaching and learning.
Defect-engineering a metal–organic framework for CO2 fixation in the synthesis of bioactive oxazolidinones

A novel series of UiO-66 structures with linker-induced defects was synthesized and fully characterized. By using a linker functionalized with a free, dangling alkylamine that replaces the ordinary carboxylate coordinating group, up to 40% of the linkers incorporated within the UiO-66 framework were defect sites. The resulting UiO-66 with linker-induced defects was then demonstrated to be a highly active heterogeneous catalyst. When applied to three-component, solvent-free cycloadditions of epoxides with aromatic amines and CO2 at ambient pressure, a diverse range of bioactive oxazolidinone compounds were isolated in significantly high yields (>90%) with quantitative conversions and regioselectivity. Finally, the catalyst was proven recyclable over 5 consecutive reactions without loss of performance.
Nuclear Structures of 17O and Time-dependent Sensitivity of the Weak s-process to the 16O(n,γ)17O Rate

We revisit the radiative neutron capture reaction 16O(n,γ)17O of astrophysical interest, based on the new reevaluated cross-section data. Several potentials are proposed to predict direct capture cross sections. The contributions from single-particle resonances to total capture cross section are quantitatively considered in Breit–Wigner formalism, taking into account the interference term between direct capture and resonant cross sections, which is crucial for the description of the behavior around the resonance energies. A new cross section is achieved based upon χ2-fittings for optimized resonance parameters using Minuit code, and it has a largely improved agreement with updated experimental data. Statistical errors are also evaluated for the total and Maxwellian-averaged cross sections. It is confirmed that the direct captures dominate the total cross sections; however, resonant contribution also becomes progressively more important as the energy increases to 100 keV. Resonance contribution can increase the reaction rates for energy region 50 keV < E < 100 keV by 5% ± 5%–25% ± 5%, and around 8% ± 5% in comparison with KADoNiS v0.3 rate and the latest data evaluations, respectively. We show a detailed propagation of the uncertainty in the 16O(n,γ) reaction rate to abundances of nuclei, including s-nuclei during the weak s-process with a multi-zone nuclear network calculation. Although an enhanced rate of 16O(n,γ) diminishes the s-process efficiency in the 25 M☉ stellar model adopted from the Modules for Experiments in Stellar Astrophysics, it can lead to larger abundances of neutrons as well as 22Ne in the late epoch of C burning.
Does a Defensive Pseudoautotomy Mechanism Exist in the Subfamily Xenodontinae? A Study of the Genus Echinanthera

Abstract. Pseudoautotomy is presumably a derived character within Lepidosauria and occurs in taxa that have lost the ability to perform autotomy. In general, species capable of employing pseudoautotomy as a defensive strategy against predators present a high frequency of damaged tails in series deposited in herpetological collections. We assessed data from three largely sympatric Echinanthera species in the Brazilian Atlantic Rainforest (E. cephalostriata, E. cyanopleura, and E. undulata) to test previous assumptions that species of Echinanthera use their tails defensively. This hypothesis derives from anecdotal observations during fieldwork and is reinforced by the number of specimens presenting tail breakage in scientific collections. In general, the frequency of damaged tails in these species resembles that of others in which pseudoautotomy has been demonstrated. Statistical analyses revealed no differences in tail breakage frequencies between sexes for the analyzed species or between the two geographical groups defined for E. cyanopleura. In contrast, we detected a significant difference between snout–vent length and sex regarding pseudoautotomy probability for E. cyanopleura, with a positive relationship between tail breakage frequency and snout–vent length.
Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues

By combining tissue engineering techniques with human-induced pluripotent stem cell (hiPSC) technology, human-derived engineered cardiac tissues (ECTs) have been developed using several cell lineage compositions and 3-dimensional geometries. Although hiPSC ECTs are relatively immature compared with native adult heart tissues, they have promising potential as a platform technology for drug-screening and disease model- ing, and as grafts for hiPSC-based regenerative heart therapy. This chapter provides the focused overview of the current status of cardiac tissue engineering technology and its possible application.
FINANCIAL RISK TOLERANCE ANALYSIS OF INDONESIAN RETAIL INVESTORS

Purpose: This study aims to analyze how risk tolerance of Indonesian retail investors is based on sociodemographic characteristics and also related to the multidimensional risk Due to the different characteristics of investors turn out to become different levels of risk tolerance for each individual investor, hence considering investor's sociodemographic factors is very important in assessing risk tolerance. Methodology: This study used quantitative analysis. The random sampling was obtained from the sample cohorts, which consist of the Indonesian retail investor club. Data was collected through an online survey and gathered 407 respondents. Then, the data was analyzed by using PLS with Smart-PLS 3.0 software. Result: Our findings showed that the most of socio-demographic variables such as age, gender, marital status, education, and income affected the financial risk tolerance, whereas ethics do not affect financial risk tolerance. And risk capacity partially mediated socio-demographics on financial risk tolerance. Application: The investor and financial advisers would use this analysis in assessing risk tolerance and determining the best type of investment and best suits the risk preference of investors. Novelty: To the best our knowledge, this study is pretty scarce. Not like the previous studies, this research also use an advanced method which explores variables interdependency. This research is the first one in Indonesia, which compiles socio-demographic variables. And also it is an enriched empirical and literature manner.
Nutritional Value of Two Underutilized Wild Plant Leaves Consumed as Food in Northern Angola: Mondia whitei and Pyrenacantha klaineana

1 Department of Agronomy, Polytechnical Higher School of Uíge, Kimpa Vita University, P.O. Box 77, Republic of Angola. 2 Botanic Garden of Kimpa Vita University, P.O. Box 77, Republic of Angola. 3 Department of Biology, Faculty of Science, University of Kinshasa, P.O. Box 190, Kinshasa XI, Democratic Republic of Congo. 4 Department of Biology, Institute of Botany, Faculty of Science, Technische Universität Dresden, 01062 Dresden, Germany. 5 Department of Biology, Faculty of Sciences, National Pedagogical University, P.O. Box 8815, Democratic Republic of Congo. Department Pharmacognosy and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Kinshasa, P.O. Box 212 Kinshasa XI, Democratic Republic of Congo. General Atomic Energy Commisariat/Regional Center for Nuclear Studies of Kinshasa (CGEA/CREN-K), Division of Life Sciences, Department of Biotechnology and Molecular Genetics, P.O. Box 868, Kinshasa XI, Kinshasa, Democratic Republic of Congo.
Study on Physicochemical and Thermal Properties of Tetrabutylammonium-Based Cation Ionic Salts Induced by Al2O3 Additive for Thermal Energy Storage Application

The physicochemical and thermal properties of tetrabutylammonium bromide (TBA-Br) and tetrabutylammonium hexafluorophosphate (TBA-PF6), and their change with the addition of Al2O3, were investigated using infrared (IR) spectroscopy and by simultaneously conducting thermal thermogravimetric (TG) analysis and differential thermal analysis (DTA) to obtain the differential scanning calorimetry (DSC) thermogram. The change in the IR data is characterized by the growth of a large peak in the range of 3500 cm−1 and the reduction of peaks below 1000 cm−1 with the additive concentration. The decomposition temperature determined from the peak in the DTG curve is nearly constant for TBA-Br, and it decreases with the addition of Al2O3 for TBA-PF6, although it does not depend on the concentration of the additives. The DTA curve of ionic salts with the addition of Al2O3 shows additional peaks, which indicates a change in the sample’s temperature at disorder or phase transitions. The variation in the melting temperature with additive concentration is similar to that of decomposition temperature. The maximum heat of fusion value was approximately 67 kJ kg−1 for the doped TBA-Br and TBA-PF6 but was achieved at a different additive concentration. This is due to the additional disorder in the system induced by the dissolution of Al2O3.
Neopterin as a diagnostic biomarker for diagnosis of inflammatory diseases like periodontitis

Neopterin is a catabolic product of guanosine triphosphate, a purine nucleotide and belongs to the group pteridines. When the cytokine interferon gamma stimulates the human macrophages, they synthesize the neopterin. It is an indicative of a pro-inflammatory immune status and hence serves as a cellular immune system marker. In most of the diseases, in which the cellular immune system is involved, we find that the neopterin concentrations are usually high. In the periodontal diseases, the levels of neopterin usually fluctuate which is proved by its increase in disease progression and a decrease after treatment. Periodontal diseases are characterized by enhanced macrophage infiltration to the periodontal lesion, so neopterin being a macrophage activation marker may be seen in higher levels. This review deals with neopterin and its mechanism and its use as a marker in the diagnosis of the periodontal diseases.
Climate change exposure and vulnerability of the global protected area estate from an international perspective

Protected areas are essential to conserve biodiversity and ecosystem benefits to society under increasing human pressures of the Anthropocene. Anthropogenic climate change, however, threatens the enduring effectiveness of protected areas in conserving biodiversity and providing ecosystem services, because it modifies and redistributes biodiversity with unknown consequences for ecosystem functioning within protected areas. Here, we assess (a) the climate change exposure of the global terrestrial protected area estate and (b) the climate change vulnerability of national protected area estates.
Impact of changing ecophysiological conditions in blood urea levels of freshwater fish Wallago attu

Definite cyclic variations were observed in blood urea levels of freshwater catfish Wallago attu. The maximal mean blood urea level (8.44Â±1.96 mg/100 ml) was noted in the month of June while minimal level in December, revealing a difference of 65.87% between the two levels. Seasonal alterations observed here in W. altu were correlated with ecophysiological factors like temperature, food availability, body metabolism, breeding cycle and hormonal changes which have been essentially found to be involved in fish life.
Commercial Vehicle Intake System Flow Field Mechanism Analysis

The numerical simulation and fluid dynamics simulation of the internal flow field and its influence mechanism of a commercial vehicle intake system were carried out aim at studying the flow field characteristics of the intake system. The internal and surface pressure, velocity, and turbulent kinetic energy distribution of intake systems under the rated operating conditions and three high torque conditions of the engine were analyzed. The simulation results showed that with the increase of the mass flow of the intake air, the pressure distribution on the surface of the intake system increased, and the pressure drop of the inlet and outlet increased rapidly. With the increase of the mass flow, the scale and number of vortexes in the intake system increased sharply. The distribution of turbulent kinetic energy is more related to the velocity field distribution. However the internal turbulent energy distribution of the intake system is concentrated under one condition. As the intake air mass flow rate drops from 1,500 kg/h to 764 kg/h, the pressure drop of the intake system drops from 2,858,566 Pa to 721,411 Pa; the average turbulent energy decreases from 5.41 m2/s2; to 0.896 m2/s2. In this paper, the research on the flow field of the engine intake system aims to provide research directions for the early stage of the structural design of the intake system of large agricultural vehicles.