Miracle-dz/UniFAR-FTUs huggingface dataset:
A Low-Power Spike-Like Neural Network Design

Modern massively-parallel Graphics Processing Units (GPUs) and Machine Learning (ML) frameworks enable neural network implementations of unprecedented performance and sophistication. However, state-of-the-art GPU hardware platforms are extremely power-hungry, while microprocessors cannot achieve the performance requirements. Biologically-inspired Spiking Neural Networks (SNN) have inherent characteristics that lead to lower power consumption. We thus present a bit-serial SNN-like hardware architecture. By using counters, comparators, and an indexing scheme, the design effectively implements the sum-of-products inherent in neurons. In addition, we experimented with various strength-reduction methods to lower neural network resource usage. The proposed Spiking Hybrid Network (SHiNe), validated on an FPGA, has been found to achieve reasonable performance with a low resource utilization, with some trade-off with respect to hardware throughput and signal representation.
Comparison different vessel segmentation methods in automated microaneurysms detection in retinal images using convolutional neural networks

Image processing techniques provide important assistance to physicians and relieve their workload in different tasks. In particular, identifying objects of interest such as lesions and anatomical structures from the image is a challenging and iterative process that can be done by computerized approaches in a successful manner. Microaneurysms (MAs) detection is a crucial step in retinal image analysis algorithms. The goal of MAs detection is to find the progress and at last identification of diabetic retinopathy (DR) in the retinal images. The objective of this study is to apply three retinal vessel segmentation methods, Laplacian-of-Gaussian (LoG), Canny edge detector, and Matched filter to compare results of MAs detection using a combination of unsupervised and supervised learning either in the normal images or in the presence of DR. The steps for the algorithm are as following: 1) Preprocessing and Enhancement, 2) vessel segmentation and masking, 3) MAs detection and Localization using a combination of Matching based approach and Convolutional Neural Networks. To evaluate the accuracy of our proposed method, we compared the output of our method with the ground truth that collected by ophthalmologists. By using the LoG vessel segmentation, our algorithm found a sensitivity of more than 85% in the detection of MAs for 100 color images in a local retinal database and 40 images of a public dataset (DRIVE). For the Canny vessel segmentation, our automated algorithm found a sensitivity of more than 80% in the detection of MAs for all 140 images of two databases. And lastly, using the Matched filter, our algorithm found a sensitivity of more than 87% in the detection of MAs in both local and DRIVE datasets.
Evaluating Environmental Threats to the Trophic Ecology of Arctic Marine Mammals

Marine mammals of the Arctic, including several species of endemic seals, toothed and baleen whales, and the polar bear, face numerous dangers that also threaten the environment of habitats all over Earth. However, the unique nature of the Arctic Ocean’s geography, similar to but in key ways distinct from the Antarctic polar region, place Arctic wildlife, and particularly marine mammals as apex predators at the “top” of food webs, at special risk.
Sustainable Business Development in the Context of Logistics in the Globalization Process

The world and society constantly evolving and now in the era of information technology and globalization, this development is much faster. This rapid pace poses a higher risk of causing negative impacts on man and his environment, whether it is the excessive production of waste or excessive exploitation of limited natural resources. Ensuring sustainability is essential to us and the awareness of this need has brought about the concept of sustainable development that regulates the satisfaction of the needs of the present generation so that future generations are not threatened. In this context, the article deals with one of the keys to sustainable mobility, which, according to the European Parliament, is an efficient and effective cost logistics as an integral part of the transport system needed for economic performance, competitiveness and environmental protection. The aim of the article is to introduce sustainable logistics and to point out the importance of its application in the company with the aim of eliminating the impact of these processes on the environment and human beings in the context of continuing globalization. To achieve research goals we used methodology included historical method, desk review, and system analysis and field research.
Diversificação de Sustento Rural a partir da Exploração do Turismo Rural: o caso da Rota das Salamarias, Marau, Rio Grande do Sul

O turismo rural surge como uma das opcoes que contribuem para a ampliacao das estrategias de sustento das familias rurais. O objetivo da pesquisa foi identificar a estrategia de diversificacao dos meios de vida de produtores rurais que exploram o turismo rural na Rota das Salamarias, localizada em Marau, no estado do Rio Grande do Sul, Brasil. A pesquisa foi qualitativa e descritiva e realizada com tres proprietarios de empreendimentos integrantes da rota mencionada. Como principal resultado da pesquisa observou-se que os motivos mencionados pelos pesquisados centram-se na ampliacao das fontes de renda, estimulo para fazer parte da rota que se alia a valorizacao do empreendimento rural, continuidade do trabalho dos antepassados em consonância com a melhoria da qualidade de vida da unidade familiar. Na implementacao da diversificacao a partir da exploracao do turismo, identificaram-se a exploracao do capital natural, fisico, humano social e financeiro. Os fatores que facilitam seu acesso foram a diversidade dos recursos naturais, as tradicoes familiares e a mao de obra disponivel. E quanto aos fatores que dificultaram sua exploracao, cita-se a fragilidade de apoio governamental para o turismo e a infraestrutura de acesso. Tambem se evidencia elementos que modificam o acesso as capitais e outros que interferem no seu acesso. Mesmo assim, o turismo no contexto estudado demanda, adicionalmente oferta de cursos de qualificacao para o setor.
"Something Worth Being Killed Over": The FBI, Cultural Propaganda, and the Murder of Fred Hampton

The 1969 murder of local Black Panther Party (BPP) leader Fred Hampton by Chicago police officers was orchestrated by the FBI field office in the city. J. Edgar Hoover, director of the FBI, authorized Hampton’s murder on the grounds that Hampton and the BPP were violent extremists. Through infiltration of the Chicago chapter of the BPP and dissemination of cultural propaganda in Black and white newspapers, the FBI turned public opinion against the party. After Hampton’s murder, the newspaper coverage of the subsequent trial further soured public opinion. Through careful analysis of internal FBI documents, trial transcripts, newspaper coverage, and FBI propaganda tactics including cartoons, comics, and falsified letters to the editor, this thesis demonstrates that the FBI used propaganda and infiltration tactics to spread false information and create moral panic about the BPP by murdering a man in cold blood and calling it justifiable.
Not All Threats are Taken Equally: Evidence from Proxy Fights

Previous research shows that activist threats lead to corporate policy concessions. We find that the threat of proxy fights is responded to differently based on its credibility. Decomposing proxy fight threats, we find that only credible threats are associated with more leveraged, more innovative, and less acquisitive corporate policies. Management, however, does not respond to noncredible threats. Further, for materialized fights, the market reaction at announcement is also conditional on the credibility of the threats. Overall, not all activist threats are responded to equally by management or the market, and only credible threats achieve disciplinary effects and favorable valuation.
Cloud Computing-Based Point-of-Sales Readiness for Surabaya’s Small/Medium Enterprises

The amplification of Internet technology primarily in cloud technology development is enabling small and medium enterprises (SME's) to utilize the affordable cost of information technology infrastructure and does not require a tremendous expenditure. Today many SME's ready to implements the Internet in their business processes as well as large-scale enterprise, particularly when the internet users also expanding. The data from http://statista.com illustrated that numeral of internet user in Indonesia rise drastically over the last three years. This research discusses the eagerness of Indonesian SME's, especially in Surabaya to utilize Point of Sales (POS) application based on cloud computing. The study related to the adoption of the POS done by qualitative research methodology. The completion of this investigation identified the essential factor of POS based on cloud computing adoption which appropriates with IT Users and Entrepreneur’s. The most significant factor in cloud computing adoption for point of sales is security and ease of use. Based on that result this study purpose the POS infrastructure for SME’s in Indonesia especially in Surabaya.
Uma arquitetura para IoT direcionada à ciência do contexto baseada em eventos distribuídos

The recent advances in the Internet of Things (IoT) area, which has provided an increasing availability of networked sensors and actuators, has given a new perspective to research in the context awareness in UbiComp. In this sense, the main contribution of this paper is the proposition of COIOT, a distributed architecture for IoT designed with the aim at providing, through rules, the proactive management of the EXEHDA Middleware interactions with the physical environment. To evaluate the functionalities of the proposed architecture we implemented a case study in the agricultural area. The achieved results are promising. Resumo. Os avanços recentes no campo de Internet das Coisas (IoT Internet of Things), que têm promovido uma disponibilidade cada vez maior de sensores e atuadores conectados em rede, trouxe uma nova perspectiva às pesquisa em ciência de contexto na Computação Ubı́qua (Ubicomp). Neste sentido, a principal contribuição deste artigo é a proposta do COIOT, uma arquitetura distribuı́da e orientada a eventos para a IoT construı́da com o objetivo de prover, através de regras, o gerenciamento proativo das interações do meio fı́sico com Middleware EXEHDA. Para validar as funcionalidades da arquitetura proposta foi implementado um estudo de caso na área da agricultura. Os resultados obtidos foram promissores. 1. Introdução Na Computação Ubı́qua os sistemas computacionais devem ser capazes de reagir às mudanças de estado das diferentes variáveis contextuais de seu interesse. Essas variáveis contextuais devem ser coletadas em ambientes altamente distribuı́dos [Knappmeyer et al. 2013]. Por sua vez, os avanços cientı́ficos e tecnológicos
MAVERICC, a phase II study of mFOLFOX6-bevacizumab (BV) vs FOLFIRI-BV as first-line (1L) chemotherapy (CT) in patients (pts) with metastatic colorectal cancer (mCRC): Outcomes by tumor location and KRAS status.

3515Background: Standard 1L mCRC treatment (tx) includes a CT backbone (e.g. modified leucovorin [LV]/5-fluorouracil [5-FU]/oxaliplatin [mFOLFOX6] or LV/ 5-FU/ irinotecan [FOLFIRI]) and a biologic .
Early Postnatal Care Service Utilization and Associated Factors among MothersWho Gave Birth in the Last 12 Months in Aseko District, Arsi Zone, South EastEthiopia in 2016

Background: Even though early postnatal care visit is one of the strategies to reduce maternal and new-born morbidity and mortality, it is the weakest of all reproductive and child health interventions in Africa and receives much less attention from healthcare providers than pregnancy and childbirth. Objective: To assess early postnatal care service utilization and associated factors among mothers who gave birth in the last 12 months in Aseko district, Arsi zone, South East Ethiopia, 2016. Method: Community based cross-sectional study was conducted from May 10th-May 20th 2016 in Aseko district, Ethiopia. A total of 382 mothers who gave birth in the last 12 months were identified using random number generated by computer from six kebeles selected by simple random sampling techniques were included in the study. Data were collected using structured questionnaire through face to face interview and entered to Epi data version 3.1 and exported to SPPS version 20. Descriptive statistics, principal factor analysis (PCA), bivariate and multivariable logistic regression analysis were used for the analysis and a P-value<0.05 was declared a statistically significant in this study. Finally, the result was presented using texts, tables and figures. Results: The level of early postnatal care service utilization was 23.7%. The reasons for not to use early PNC services were: Having no information on the importance of early PNC services 140 (48.5%) followed by lack/no transportation access 76 (26.3%). In multivariable logistic regression analysis; experience of early postnatal care utilization for previous child (AOR=4.211; 95% CI: 1.548, 11.458), Institutional delivery (AOR=2.778; 95% CI: 1.386, 5.568), Women decision making power (AOR=4.103; 95% CI: 2.087, 8.067), Information/advise about early postnatal care services from health profession (AOR=5.049; 95% CI: 2.074, 12.289), Distance/time took to arrive health facility on foot (AOR=0.458; 95% CI: 0.231, 0.908) and Access to transportation (AOR=2.655; 95% CI: 1.322, 5.330) were found to be predictors of early PNC service utilization. Conclusion and Recommendations: Less than quarters (23.7%) of the respondents were utilizing early postnatal care services in the district. Experience of early PNC utilization, place of delivery, decision making power, information/advice from health profession, distance of health facility and access to transport were statistically significant for early postnatal care utilization. Strengthening health facilities to enhance service provision and information education and communication, decision making power of the women, improving transportation service and encouraging institutional delivery are necessary measures to enhance early PNC service utilization in the district.
Novel agents in treatment of acute myeloid leukemia

wencjonalną chemioterapią umozliwia osiągniecie remisji calkowitej u 60–80% chorych w wieku ponizej 55–60 lat, ale tylko 30–40% z nich przezywa 5 lat. U chorych w starszym wieku wyniki leczenia są zle. Poznanie patomechanizmu i podstaw molekularnych ostrych bialaczek umozliwilo obecnie opracowanie nowych ukierunkowanych sposobow terapii. W pracy przedstawiono nowe leki, badane w leczeniu ostrej bialaczki szpikowej w monoterapii i terapii skojarzonej: gemtuzumab ozogamycin, inhibitory oporności wielolekowej, inhibitory FLT3, inhibitiory transferazy farnezylowej, leki hamujące angiogeneze, modulatory apoptozy, leki epigenetyczne oraz nowe cytostatyki.
Personal Brands of ESports Athletes: An Exploration of Evaluation Mechanisms

Esports organisations and athletes, being participants of an attention-driven market, are constantly discussed, compared and evaluated by spectators in a cross-media-based process on such platforms as Twitch, Reddit and others. In this work, we discuss an approach to analyse valuation practices related to esports spectatorship based on the concepts of a brand as an organising device, using computational text analysis tools and reconstruction of personal networks
The Care of Facial Palsy after Inferior Alveolar Nerve Block Anesthesia and Temporomandibular Joint Dislocation in Diabetic Mellitus Patient: A Case Report

The Care of Facial Palsy after Inferior Alveolar Nerve Block Anesthesia and Temporomandibular Joint Dislocation in Diabetic Mellitus Patient -A Case ReportChun-Ui Lee, Jae-Ha Yoo, Byung-Ho Choi, and Jong-Bae Kim* Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University (Wonju Christian Hospital), Wonju *Department of Dentistry (Oral and Maxillofacial Surgery), Dong San Medical Center, College of Medicine, Keimyung University, Daegu, Korea Bell's palsy is an isolated facial paralysis of sudden onset caused by a neuritis of the seventh nerve within the facial canal. It occurs often in the adult man with a history of recent exposure to local cold, such as sleeping next to an open window, or in some cases it occurs after infections of the nasopharynx or masticator spaces. Especially, this neuropathy have linked with the major collagen disorders (diabetes mellitus). A segmental demyelination develops rapidly, with vascultitis in microinfarcts and ischemia to the nerve segment. The authors experienced about the bizarre neurological symptom of Bell's palsy after inferior alveolar nerve block anesthesia and TMJ dislocation in diabetic mellitus. The early and correct consultation with the multiple medical and dental departments was important to prevent the inadequate care & medicolegal problems. (JKDSA 2011; 11: 45~50) 󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏
Extended-Spectrum β-Lactamases and Klebsiella Infections

Extended-spectrum β-lactamases (ESBLs) render organisms resistant to a variety of β-lactam antibiotics, including third-generation cephalosporins. ESBLs are a growing problem worldwide, especially with Klebsiella pneumoniae. Despite the high prevalence of these enzymes, little information exists about their effect on treatment outcome, and researchers have performed no controlled trials of treatment for infections with ESBL-producing organisms. Two studies recently …
Clinical applications of exosome membrane proteins

Abstract Extracellular vesicles (EVs) are small membranous particles that can mediate cell-to-cell communication and which are divided into at least three categories according to their subcellular origin and size: exosomes, microvesicles, and apoptotic bodies. Exosomes are the smallest (30–150 nm) of these EVs, and play an important role in EV-mediated cell-to-cell interactions, by transferring proteins, nucleic acids and, lipids from their parental cells to adjacent or distant cells to alter their phenotypes. Most exosome studies in the past two decades have focused on their nucleic acid composition and their transfer of mRNAs and microRNAs to neighboring cells. However, exosomes also carry specific membrane proteins that can identify the physiological and pathological states of their parental cells or indicate their preferential target cells or tissues. Exosome membrane protein expression can also be directly employed or modified to allow exosomes to serve as drug delivery systems and therapeutic platforms, including in targeted therapy approaches. This review will briefly summarize information on exosome membrane proteins components and their role in exosome–cell interactions, including proteins associated with specific cell-interactions and diseases, and the potential for using exosome membrane proteins in therapeutic targeting approaches.
Search for Human-Specific Proteins Based on Availability Scores of Short Constituent Sequences: Identification of a WRWSH Protein in Human Testis

Little is known about protein sequences unique in humans. Here, we performed alignment-free sequence comparisons based on the availability (frequency bias) of short constituent amino acid (aa) sequences (SCSs) in proteins to search for human-specific proteins. Focusing on 5-aa SCSs (pentats), exhaustive comparisons of availability scores among the human proteome and other nine mammalian proteomes in the nonredundant (nr) database identified a candidate protein containing WRWSH, here called FAM75, as human-specific. Examination of various human genome sequences revealed that FAM75 had genomic DNA sequences for either WRWSH or WRWSR due to a single nucleotide polymorphism (SNP). FAM75 and its related protein FAM205A were found to be produced through alternative splicing. The FAM75 transcript was found only in humans, but the FAM205A transcript was also present in other mammals. In humans, both FAM75 and FAM205A were expressed specifically in testis at the mRNA level, and they were immunohistochemically located in cells in seminiferous ducts and in acrosomes in spermatids at the protein level, suggesting their possible function in sperm development and fertilization. This study highlights a practical application of SCS-based methods for protein searches and suggests possible contributions of SNP variants and alternative splicing of FAM75 to human evolution.
Analytical Results to Fuel-optimal Spacecraft Formation Maneuver

In this study, analytical results are obtained for fuel-optimal spacecraft formation maneuver, including initialization and reconfiguration. The method consists of two stages. The first is parameterization of the problem and a new form of the problem is developed for simplicity. Second, the out-of-plane and in-plane maneuver are studied with the help of a useful inequality introduced and proved, the lower bound of the fuel consumption and the corresponding constraints of the control forces are derived and obtained. The result shows that the minimum total fuel consumption depends on the relative size parameters, and that the existence of optimal control algorithms depends upon the initial conditions. Numerical simulation of application proved the validity and efficiency of the proposed method, which can also be utilized in the maneuver of PCF.
The Brussels Effect

Chapter 2 lays out the conditions under which a single jurisdiction exerts global regulatory authority and shows why the EU today is in a unique position to assume the role of a global regulatory hegemon. These conditions explain the emergence and prevalence of the Brussels Effect. A country’s market size is a well-understood proxy for its ability to exercise regulatory authority over foreign corporations and individuals. But market size alone does not guarantee global regulatory influence. The state must also have the regulatory capacity as well as the political will to generate stringent rules. Moreover, the Brussels Effect only occurs when the EU regulates inelastic targets, such as consumer markets as opposed to capital. Unlike capital, consumers are not able to flee to less regulated jurisdictions, compromising the EU’s regulatory clout. Finally, EU standards become global only when companies’ production or conduct is non-divisible—in other words, when a company’s benefits of adhering to a single standard exceed the benefits of taking advantage of laxer standards in other markets. These conditions, taken together, explain why the EU is the only regulatory regime that can wield unilateral regulatory influence across global markets today.