Miracle-dz/UniFAR-FTUs huggingface dataset:
Synthesis of glycerol carbonate by direct carbonylation of glycerol with CO2 over solid catalysts derived from Zn/Al/La and Zn/Al/La/M (M = Li, Mg and Zr) hydrotalcites

Zn/Al/La and Zn/Al/La/M (M = Li, Mg, Zr) mixed oxides were obtained by calcination of hydrotalcite precursors and tested for glycerol carbonate (GC) synthesis from CO2 carbonylation. The results indicated the catalytic activity may be associated with the large specific surface area, the high surface content of Zn and the high binding energy of Zn atoms as well as the high density of moderately basic sites. The good result was obtained on the catalyst with a molar ratio of Zn : La : Al = 4 : 1 : 1 and, within a certain range, glycerol conversion and GC yield increase linearly upon the increase of the density of moderately basic sites. In addition, the catalytic activity was obviously improved upon introduction of Li, Mg and Zr. The effect of reaction parameters on the carbonylation of glycerol was also studied. The DRIFTS results suggest that the activated CO2 may be in the form of a bridged bidentate carbonate that inserts into zinc glycerolate to form an intermediate species of a seven-membered ring ester followed by intramolecular rearrangement to produce GC. Theoretical calculation results indicated that the seven-membered ring ester has good stability and the formation process happens spontaneously.
Unleashing the power of immunotherapy and targeted therapy combinations: Advancing cancer care or discovering unknown toxicities?

Objective The purpose of this review was to summarize the triumphs and pitfalls of tyrosine kinase inhibitor (TKI) and immune checkpoint inhibitor (ICI) combinations. Data sources: A literature review of PubMed was conducted and studies were included if they were classified as a clinical trial and assessed TKI and ICI combinations for solid tumor malignancies. Dates of literature search included January 1, 1988 through September 22, 2019. Data summary: In the past decade, TKI and ICI monotherapy strategies have changed the management of many advanced solid tumors through their unique mechanisms of action. Preclinical data suggests that TKIs may be able to sensitize tumors to ICI therapy via direct and indirect pathways; however, optimal mechanisms to support various TKI and ICI combinations have yet to be determined. The FDA recently approved TKI and ICI combinations for renal cell carcinoma, endometrial carcinoma, and melanoma. Several other tumor types currently have TKI and immunotherapy combinations under investigation with mixed results. Dual therapy with TKIs and immunotherapy have the potential to be synergistic and improve patient outcomes; however, careful consideration will need to be taken in regard to what TKI and immunotherapy are combined. Conclusions Future research will be needed to determine appropriate sequencing of TKIs and ICIs after progression on combination therapy. Continued research is necessary to determine optimal dual TKI and immunotherapy options.
Covered self‐expandable metal stents versus plastic stents for preoperative biliary drainage in patient receiving neo‐adjuvant chemotherapy for borderline resectable pancreatic cancer: Prospective randomized study

This single‐center comparative randomized superiority study compared biliary stenting using fully covered self‐expandable metal stents (FCSEMS) and biliary stenting using plastic stents (PS) in preoperative biliary drainage of patients with borderline resectable pancreatic cancer (BRPC) who are planned to undergo a single regimen of neo‐adjuvant chemotherapy (NAC).
Sarcocystis camelicanis increases interleukin (IL)-6 expression in one-humped camels (Camelus dromedarius) from Riyadh and Al Qassim, Saudi Arabia

Abstract Sarcocystis spp. are intracellular protozoan parasites with an intermediate-definitive host life cycle based on a prey–predator relationship. Sarcocystis infection is common among different vertebrates including humans. The pathogenicity of Sarcocystis spp. is of varied significance including a possible lethal effect for the host. The goal of the present study was to investigate the inflammatory activity of Sarcocystis spp. in different organs of naturally infected camels. The tongue, esophagus, heart, diaphragm, and skeletal muscles were collected from 50 camels, and the tissues assessed for the presence of Sarcocystis spp. by macroscopic examination, light microscopy, and transmission electron microscopy (TEM). Moreover, expression of the interleukin (IL)-6 was analyzed using reverse transcriptase quantitative polymerase chain reaction (qPCR). Microscopic Sarcocystis spp. cysts were found in camels. TEM identified the cysts as Sarcocystis camelicanis (S. camelicanis). Sarcocystis infection increased inflammation by stimulation of IL-6 expression in different organs of the camels, particularly in those from the Al-Qassim region.
From Burnout to Wholehearted Engagement: A Qualitative Exploration of Psychiatry Residents’ Experience of Stress

Supplemental Digital Content is available in the text. Purpose Physician burnout is endemic across medical education and has numerous deleterious effects. Given the prevalence and negative effects of burnout, there is an urgent need to understand how residents experience and cope with stress and develop explanatory models that inform the development of more effective interventions. Method Using a qualitative, constructivist approach informed by grounded theory, the authors conducted semistructured interviews from March to April 2019, in which psychiatry residents were asked about their experiences of stress and how they coped. First- through fourth-year trainees at Zucker Hillside Hospital at Northwell Health, Glen Oaks, New York, were invited. Two authors independently and inductively coded deidentified transcripts. A constant comparative approach was used to analyze data and support construction of themes. Theoretic sufficiency was observed after 14 interviews. Results The authors constructed an explanatory model for how residents cope with stress and whether they tended toward burnout or wholehearted engagement. The model included 3 themes: self-care, work relationships, and meaning making. Self-care, including time spent with others, provided connection and belonging that bolstered physicians’ developing identities. Interpersonal relationships at work profoundly influenced the experience of residents. Positive peer and supervisor relationships enhanced confidence and perseverance. Negative role models and conflict engendered feelings of inadequacy. The ability to shift perspective and build meaning through examining moral values in the face of challenges was crucial for residents who reported success at coping with stress. Residents identified personal psychotherapy as an especially important strategy to facilitate meaning making. Conclusions These findings provide guidance for how residency programs may help residents cope with stress and move away from burnout toward wholehearted engagement. Strategies may include reducing barriers to self-care and to accessing help early in training, creating spaces that promote peer connection and providing training in addressing conflict, and facilitating engagement in meaning-making activities.
Role of a multidimensional prognosis in‐hospital monitoring for older patients with prolonged stay

The Multidimensional Prognostic Index (MPI) is a prognostic tool—amongst others—validated for mortality, length of hospital stay (LHS) and rehospitalisation risk assessment. Like the Comprehensive Geriatric Assessment (CGA), the MPI is usually obtained at hospital admission and discharge, not during the hospital stay. The aim of the present study was to address the role of an additional CGA‐based MPI measurement during hospitalisation as an indicator of “real‐time” in‐hospital changes.
Monitoring Training Volume Through Maximal Number of Repetitions or Velocity-Based Approach.

PURPOSE This study aimed (1) to analyze the interindividual variability in the maximal number of repetitions (MNR) performed against a given relative load (percentage of 1-repetition maximum [%1RM]) and (2) to examine the relationship between the velocity loss (VL) magnitude and the percentage of completed repetitions with regard to the MNR (%Rep), when the %1RM is based on individual load-velocity relationships. METHODS Following an assessment of 1RM strength and individual load-velocity relationships, 14 resistance-trained men completed 5 MNR tests against loads of 50%, 60%, 70%, 80%, and 90% 1RM in the Smith machine bench-press exercise. The relative loads were determined from the individual load-velocity relationship. RESULTS Individual relationships between load and velocity displayed coefficients of determination (R2) ranging from . 986 to . 998. The MNR showed an interindividual coefficient of variation ranging from 8.6% to 33.1%, increasing as the %1RM increased. The relationship between %Rep and the magnitude of VL showed a general R2 of . 92 to . 94 between 50% and 80% 1RM, which decreased to . 80 for 90% 1RM. The mean individual R2 values were between . 97 and . 99 for all loading conditions. The %Rep when a given percentage of VL was reached showed interindividual coefficient of variation values ranging from 5% to 20%, decreasing as the %Rep increased in each load condition. CONCLUSIONS Setting a number of repetitions had acceptable interindividual variability, with moderate relative loads being adjusted based on the individual load-velocity relationship. However, to provide a more homogeneous level of effort between athletes, the VL approach should be considered, mainly when using individual VL-%Rep relationships.
Insights into elections: An ensemble bot detection coverage framework applied to the 2018 U.S. midterm elections

The participation of automated software agents known as social bots within online social network (OSN) engagements continues to grow at an immense pace. Choruses of concern speculate as to the impact social bots have within online communications as evidence shows that an increasing number of individuals are turning to OSNs as a primary source for information. This automated interaction proliferation within OSNs has led to the emergence of social bot detection efforts to better understand the extent and behavior of social bots. While rapidly evolving and continually improving, current social bot detection efforts are quite varied in their design and performance characteristics. Therefore, social bot research efforts that rely upon only a single bot detection source will produce very limited results. Our study expands beyond the limitation of current social bot detection research by introducing an ensemble bot detection coverage framework that harnesses the power of multiple detection sources to detect a wider variety of bots within a given OSN corpus of Twitter data. To test this framework, we focused on identifying social bot activity within OSN interactions taking place on Twitter related to the 2018 U.S. Midterm Election by using three available bot detection sources. This approach clearly showed that minimal overlap existed between the bot accounts detected within the same tweet corpus. Our findings suggest that social bot research efforts must incorporate multiple detection sources to account for the variety of social bots operating in OSNs, while incorporating improved or new detection methods to keep pace with the constant evolution of bot complexity.
The Sleep Apnea-specific Pulse Rate Response Predicts Cardiovascular Morbidity and Mortality.

RATIONAL Randomized controlled trials have been unable to detect a cardiovascular benefit of continuous positive airway pressure (CPAP) in unselected patients with obstructive sleep apnea (OSA). We hypothesize that deleterious cardiovascular outcomes are concentrated in a subgroup of patients with heightened apnea/hypopnea-related pulse rate response. METHODS We measured the pulse rate response to apneas/hypopneas (∆HR) in the Multi-Ethnic Study of Atherosclerosis (MESA, N=1395) and the Sleep Heart Health Study (SHHS, N=4575). MESA data were used to determine the functional form of association between ∆HR and subclinical cardiovascular biomarkers, while primary analyses tested the association of ∆HR with non-fatal/fatal CVD and all-cause mortality in longitudinal data from the SHHS. RESULTS In MESA, U-shaped relationships were observed between subclinical CVD biomarkers (coronary artery calcium; NT-proBNP; Framingham risk score) and ∆HR; notably, high ∆HR (upper quartile) was associated with elevated biomarker scores compared to mid ∆HR (25th-75th centiles). In SHHS, individuals with high ∆HR compared to mid ∆HR were at increased risk of non-fatal/fatal CVD and all-cause mortality (non-fatal: 1.60 [1.28-2.00]; fatal: 1.68 [1.22-2.30]; all-cause: 1.29 [1.07-1.55], adjusted hazard ratio [95%CI]). The risk associated with high ∆HR was particularly high in those with substantial hypoxic burden (non-fatal: 1.93 [1.36-2.73]; fatal: 3.50 [2.15-5.71]; all-cause: 1.84 [1.40-2.40]) and was exclusively observed in non-sleepy individuals. CONCLUSIONS Individuals with OSA who demonstrate elevated pulse rate response are at increased risk of cardiovascular morbidity and mortality. This study identifies a prognostic biomarker for OSA that appears useful for risk stratification and patient selection for future clinical trials.
Mapping the Scientific Landscape of Diabetes Research in Malaysia (2000–2018): A Systematic Scientometrics Study

The escalated burden of diabetes on the population’s health has catalyzed rigorous scientific research to produce appropriate evidence for treatment and control. Malaysia suffers from the leading diabetes epidemic within the Western Pacific region. It is crucial to map the scientific landscape of diabetes research for the country to identify trends in productivity and determine whether research efforts are directed toward the needs-gaps priority for evidence synthesis that could be used for the drafting of policies and guidelines. This systematic scientometrics study was conducted to map the scientific research output (trends and distribution, citation frequency, keywords link visualization, and thematic cluster conceptualization) related to diabetes between 2000–2018 in Malaysia. Using three international databases (PubMed, EMBASE, Scopus) and one local database (MyCite), scientific publication records related to diabetes in Malaysia between 2000 and 2018 were retrieved and analyzed using quantitative and qualitative methodologies. Microsoft Excel 2016, EndNote X9.2, BibExcel 2016, GraphPad Prism 8.0. 1, VOS viewer software 1.6. 13, and R software version 1.3. 959 were used to analyze the trend and contents of diabetes publications. A total of 2094 publication records that accounted for 35,497 citations were analyzed. Kuala Lumpur was the most scientifically productive state in Malaysia, contributing 754 papers. Medical Journal of Malaysia had the highest number of publications. The inflection point of the Malaysian diabetes research output was in 2013, with most publications being non-collaborative research works. Most publications originated from academia, especially from local public universities. The overall publication productivity of diabetes research in Malaysia was conceptualized into eleven thematic clusters, with clinical and animal studies being the most prevalent themes. The diabetes literature in Malaysia has grown steadily over the past 19 years. However, the cumulative evidence remains inadequate and is insufficiently powered to guide policymaking and the control of diabetes. It does not yet seem feasible to direct the diabetes epidemic curve to a plateau for the Malaysian population based on Malaysian diabetes publications.
Acute acetate administration increases endogenous opioid levels in the human brain: A [11C]carfentanil molecular imaging study

Introduction: A recent study has shown that acetate administration leads to a fourfold increase in the transcription of proopiomelanocortin (POMC) mRNA in the hypothalamus. POMC is cleaved to peptides, including β-endorphin, an endogenous opioid (EO) agonist that binds preferentially to the µ-opioid receptor (MOR). We hypothesised that an acetate challenge would increase the levels of EO in the human brain. We have previously demonstrated that increased EO release in the human brain can be detected using positron emission tomography (PET) with the selective MOR radioligand [11C]carfentanil. We used this approach to evaluate the effects of an acute acetate challenge on EO levels in the brain of healthy human volunteers. Methods: Seven volunteers each completed a baseline [11C]carfentanil PET scan followed by an administration of sodium acetate before a second [11C]carfentanil PET scan. Dynamic PET data were acquired over 90 minutes, and corrected for attenuation, scatter and subject motion. Regional [11C] carfentanil BPND values were then calculated using the simplified reference tissue model (with the occipital grey matter as the reference region). Change in regional EO concentration was evaluated as the change in [11C]carfentanil BPND following acetate administration. Results: Following sodium acetate administration, 2.5–6.5% reductions in [11C]carfentanil regional BPND were seen, with statistical significance reached in the cerebellum, temporal lobe, orbitofrontal cortex, striatum and thalamus. Conclusions: We have demonstrated that an acute acetate challenge has the potential to increase EO release in the human brain, providing a plausible mechanism of the central effects of acetate on appetite in humans.
A hotspot for enhancing insulin receptor activation revealed by a conformation-specific allosteric aptamer

Abstract Aptamers are single-stranded oligonucleotides that bind to a specific target with high affinity, and are widely applied in biomedical diagnostics and drug development. However, the use of aptamers has largely been limited to simple binders or inhibitors that interfere with the function of a target protein. Here, we show that an aptamer can also act as a positive allosteric modulator that enhances the activation of a receptor by stabilizing the binding of a ligand to that receptor. We developed an aptamer, named IR-A43, which binds to the insulin receptor, and confirmed that IR-A43 and insulin bind to the insulin receptor with mutual positive cooperativity. IR-A43 alone is inactive, but, in the presence of insulin, it potentiates autophosphorylation and downstream signaling of the insulin receptor. By using the species-specific activity of IR-A43 at the human insulin receptor, we demonstrate that residue Q272 in the cysteine-rich domain is directly involved in the insulin-enhancing activity of IR-A43. Therefore, we propose that the region containing residue Q272 is a hotspot that can be used to enhance insulin receptor activation. Moreover, our study implies that aptamers are promising reagents for the development of allosteric modulators that discriminate a specific conformation of a target receptor.
Changes in Visual Function and Correlations with Inner Retinal Structure in Acute and Chronic Leber’s Hereditary Optic Neuropathy Patients after Treatment with Idebenone

Progressive impairment and degeneration of retinal ganglion cells (RGC) and nerve fibers in Leber’s hereditary optic neuropathy (LHON) usually cause permanent visual loss. Idebenone is currently the only approved treatment. However, its therapeutic potential in different stages of LHON has not been definitely clarified. We aimed to investigate the changes in visual function and correlations with retinal structure in acute and in chronic LHON patients after treatment with idebenone. Twenty-three genetically confirmed LHON patients were followed during treatment using logMAR charts, automated perimetry and optical coherence tomography (OCT). Mean visual acuity improved significantly in acute patients treated within 1 year from onset (−0.52 ± 0.46 logMAR from nadir), in early chronic patients who started after 1–5 years (−0.39 ± 0.27 logMAR from baseline), and in late chronic patients with treatment initiation after >5 years (−0.33 ± 0.28 logMAR from baseline, p < 0.001 all groups). In acute and in chronic patients, strong correlations between OCT and visual function parameters were present only after treatment. This and the sustained visual recovery after treatment may indicate a reactivated signal transduction in dysfunctional RGC that survive the acute phase. Our results support previous evidence that idebenone has therapeutic potential in promoting visual recovery in LHON.
Influence of Fuel and Condition in Combustion Synthesis on Properties of Copper (II) Oxide Nanoparticle

Copper oxide nanoparticles have been received attraction due to their unique properties and potential future applications. In present work nanostructure Copper (II) oxide (CuO) spherical nanoparticle synthesized by solution combustion method and the influence of different fuel and condition on the properties of CuO particle was investigated. Crystalline phase and size indicated by applying XRD and particle size distribution studied further using DLS. Scanning electron microscopy (SEM) was used for morphological study and EDAX analysis shows composition of CuO particles. Nanostructure of copper (II) oxide particle studied further by Transmission electron microscopy (TEM) and selected area electron diffraction (SAED) applied for detail study on crystalline structure of particles.
Equation of State for Supercooled Water at Pressures up to 400 MPa

An equation of state is presented for the thermodynamic properties of cold and supercooled water. It is valid for temperatures from the homogeneous ice nucleation temperature up to 300 K and for pressures up to 400 MPa, and can be extrapolated up to 1000 MPa. The equation of state is compared with experimental data for the density, expansion coefficient, isothermal compressibility, speed of sound, and heat capacity. Estimates for the accuracy of the equation are given. The melting curve of ice I is calculated from the phase-equilibrium condition between the proposed equation and an existing equation of state for ice I.
Evaluating the Effect of Arterial Pulsation on Cerebrospinal Fluid Motion in the Sylvian Fissure of Patients with Middle Cerebral Artery Occlusion Using Low b-value Diffusion-weighted Imaging

Purpose Decrease in signal of the cerebrospinal fluid (CSF) on low b-value diffusion weighted image (DWI) due to non-uniform flow can provide additional information regarding CSF motion. The purpose of the current study was to evaluate whether arterial pulsations constitute the driving force of CSF motion. Methods We evaluated the CSF signals within the Sylvian fissure on low b-value DWI in 19 patients with unilateral middle cerebral artery (MCA) occlusion. DWI with b-value of 500 s/mm2 was evaluated for a decrease in CSF signal within the Sylvian fissure including the Sylvian vallecula and lower, middle, and higher Sylvian fissures and graded as follows: the same as contralateral side; smaller signal decrease than that on contralateral side; and no signal decrease. MR angiography (MRA) findings of MCA were graded as follows: the same as contralateral, lower signal than contralateral signal, and no signal. In 15 patients, regional cerebral blood flow (rCBF) was evaluated using single-photon emission computed tomography (SPECT) studies and graded as > 90%, 90%–70%, and < 70% rCBF compared to contralateral. The correlations between the gradings were evaluated using G likelihood-ratio test. Results There was no statistically significant correlation between the MRA and low b-value DWI gradings of CSF in all areas. There were statistically significant correlations between the decreases in CBF on SPECT and CSF signals in the middle Sylvian fissure. Conclusion The driving force of CSF pulsation in the Sylvian sinus may be related to the pulsations of the cerebral hemisphere rather than direct arterial pulsations.