Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of metabolic syndrome in psoriatic arthritis compared with psoriasis: a cross-sectional study in a South Indian population

Objective The objective of this study was to assess and compare the prevalence of metabolic syndrome (MetS) in patients with psoriasis (PsO) and in those with psoriatic arthritis (PsA). Materials and methods This was a cross-sectional study with no follow-up and was performed among outpatients attending the speciality clinics of an institutional tertiary referral centre. A consecutive sample of 100 patients with PsO was included in the study. Height, weight, BMI, blood pressure and waist circumference of patients were measured at the time of enrolment. Venous samples were taken after 8 h of overnight fasting for the estimation of serum cholesterol, triglycerides and plasma glucose levels. Results MetS was seen in 62.9% (17) of patients with PsO and in 32.8% of patients with PsA. This difference was statistically highly significant (P < 0.001). Conclusion MetS is common in Asian Indian patients with PsA than in patients with cutaneous PsO only.
Nourodevelopmental follow-up in high-risk infants: review article

Growing and developing are influenced by genetic, social and environmental factors and it's most important and initial phase step is formed of the early life of the fetus and infant. According to the world health organization, the incidence of preterm birth and low birth weight are increasing in most countries that most of it related to developing countries. Low birth weight (LBW) and preterm birth are one the most important causes of death in the world and therefore are considered as one of the major health problems that can affect growing and developing so that it can threaten public health. Advances in medical technology in recent decades at intensive care unit, increased survival of premature infants and high-risk specialist care is needed, but failed, to reduce the complications of premature birth but it couldn’t reduce complications of preterm birth. There is also an increased recognition of the potential disconnect between perinatal outcomes and long-term outcomes. The administration of oxygen and postnatal steroids are prime examples of interventions that may have immediate positive effects but negative long-term effects. Many premature babies will be encounter with mobility problems, cognitive, neurosensory impairments, cerebral palsy, cognitive and language delays, neuromotor developmental delay, blindness and hearing loss, behavioral and psychosocial disorders, learning difficulties and dysfunction in scholastic performances in the future. These disadvantages appear to persist into adulthood and therefore have broad implications for society. Without a doubt, one of the tragedies of the world is people with physical or mental damage caused by premature birth, many of these disorders are not early diagnosed and the prediction of long term complications of infants discharged from the NICU is difficult. Although nourodevelopmental follow-up of these babies is a necessary part of the neonatal assessment but there is no standard process for it. The present review article aims to introduce the care process and tools that is used for following-up these babies, also introduces the application of screening tools for neuro-developmental care.
THE EFFECTS OF HAMSTRING DELAYED ONSET MUSCLE SORENESS ON FUNCTIONAL KNEE JOINT STABILITY

of Thesis Presented to the Graduate School of the University of Florida in Partial Fulfillment of the Requirements for the Degree of Master of Science in Exercise and Sport Sciences THE EFFECTS OF HAMSTRING DELAYED ONSET MUSCLE SORENESS ON FUNCTIONAL KNEE JOINT STABILITY By Kyle Andrew Smink August 2003 Chair: Mark D. Tillman, PhD Major Department: Exercise and Sport Sciences Dynamic joint stability is an essential component of athletic performance. If deficits in dynamic stability exist, the athlete may be unable to perform at previous levels of competition and may also be prone to injury. Delayed onset muscle soreness (DOMS) is a response to unaccustomed bouts of strenuous exercise that results in certain physical and physiological markers being present in the local tissue. The purpose of this investigation was to determine the effects of hamstring DOMS on functional knee joint stability. Thirty subjects (18 females, 12 males) with no previous knee injuries participated in this investigation. Subjects were assigned to one of two groups (DOMS, Control). Baseline measures of hamstring flexibility, pressure pain threshold (PPT), passive range of motion pain threshold (PROMPT), hamstring latency, and time to stabilization (TTS) were measured. Subjects in the experimental group then performed 6 sets of 10 eccentric
Mortality, disability, psychiatric treatment and medication in first-onset schizophrenia in Finland : the register linkage study

The focus of this study was to examine mortality, disability, psychiatric treatment and medication utilizing register-based five-year follow-up data on all first-onset schizophrenia patients between the years 1995 to 2003 in Finland. The data were obtained from the Finnish Hospital Discharge Register, the national Finnish Causes of Death Register, and registers of pensions and reimbursed medicines. People with first-onset schizophrenia had a 4.45-fold higher mortality rate than the general population. Mortality was significantly elevated in all age groups. The most prominent single unnatural cause of death was suicide and the most common natural cause of death was circulatory diseases. Half of all first-onset schizophrenia patients retired on disability pension within the five-year follow-up period. Men retired at an earlier age and more commonly than women. Regional differences in mortality and disability retirement were evident. Patients first identified as outpatients had better outcomes than patients first identified following hospitalization. In total, 40% of outpatient-treated patients and 74% of hospital-treated patients had experienced a relapse during follow-up period. The use of second generation antipsychotics (SGAs) was associated with reduced risk of allcause mortality, while clozapine was associated with lower suicide risk. First generation antipsychotics (FGAs) were associated with increased all-cause mortality and, particularly chlorprothixene, with increased suicide mortality. An increased likelihood of cardiovascular death was found among users of levomepromazine. In antidepressants, use of mirtazapine was associated with increased risk of suicide. In this study, the results and outcomes of first-onset schizophrenia patient treatment were analysed using register-based data. The results indicate that the outcome of first-onset schizophrenia is not good enough. Regional differences were seen in mortality and treatment practices. In clinical work more attention should be paid to health promotion and somatic screening, but also treatment of depressive symptoms. The results indicate that more effective treatments and rehabilitation are needed along with improved equality of treatment practices between hospital districts.
Facteurs environnementaux dans l'étiologie de la maladie de Parkinson

ABSTRACT: We examined the role of the environment in the development of Parkinson's disease (PD). A group of 42 parkinsonians have been compared with a group of 84 matched controls. The epidemiological study (1987-1989) covered the territory of the Community Health Department of Valleyfield, in southern Quebec (Canada). Odds ratio adjusted for age and sex were calculated for seven environmental factors. A decreased risk for PD was associated with residence in rural areas (OR: 0.31; p ≤ 0.05) and residence near industry or mining (OR: 0.15; p ≤ 0.05). An increased risk for PD seems to be associated with occupational exposure to the three metals Mn, Fe and Al (OR: 2.28; p = 0.07) especially when the duration of exposure is longer than 30 years (OR: 13.64; p ≤ 0.05). Other environmental factors not found to be associated with PD were: pesticides manipulation, farm work, industrial work and well water consumption.
Phase II study of eribulin (E7389) in patients (pts) with advanced urothelial cancer (UC)--Final report: A California Cancer Consortium-led NCI/CTEP-sponsored trial.

4539 Background: There is an unmet need for new agents in locally advanced and metastatic UC, particularly for pts with renal dysfunction. Microtubule directed agents (vincas, taxanes) have activity in UC. A prior first in human phase I study of eribulin, a microtubulin modulator derived from the black Pacific sea sponge toxin showed that eribulin/metabolites are minimally renally excreted (T. Synold, ASCO A2054, 2005). Encouraging activity was evident in UC. Here we report the results of a subsequent ph II study in advanced UC. Methods: The ph II component of this study accrued patients with normal creatinine or calculated CrCl ≥60mL/m, UC: any histological type and no prior cytotoxic therapy for advanced disease (neo/adjuvant allowed). Eribulin 1.4mg/m2 was given IV on d 1 & 8, q3weeks. Endpoints: response rate (RR) >20% was deemed interesting in a 2-stage design requiring ≥2 responses/21 pts to proceed to total 41 pts; PFS and OS. Results: 40 pts entered. Patient characteristics: histology: 35 with tra.
A joint guideline from the Canadian Task Force on Preventive Health Care and the Canadian Breast Cancer Initiative's Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer

Objective: To assist women and their physicians in making decisions regarding the prevention of breast cancer with tamoxifen and raloxifene. Evidence: Systematic review of English-language literature published from 1966 to August 2000 retrieved from MEDLINE, HealthSTAR, Current Contents and Cochrane Library. Values: The strength of evidence was evaluated using the methods of the Canadian Task Force on Preventive Health Care and the Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer. Recommendations: • Women at low or normal risk of breast cancer (Gail risk assessment index < 1.66% at 5 years): There is fair evidence to recommend against the use of tamoxifen to reduce the risk of breast cancer in women at low or normal risk of the disease (grade D recommendation).  Women at higher risk of breast cancer (Gail index ≥ 1.66% at 5 years): Evidence supports counselling women at high risk on the potential benefits and harms of breast cancer prevention with tamoxifen (grade B recommendation). The cutoff for defining high risk is arbitrary, but the National Surgical Adjuvant Breast and Bowel Project P-1 Study included women with a 5-year projected risk of at least 1.66% according to the Gail index, and the average risk of patients entered in the trial was 3.2%. Examples of high-risk clinical situations are 2 first-degree relatives with breast cancer, a history of lobular carcinoma in situ or a history of atypical hyperplasia. As the risk of breast cancer increases above 5% and the benefits outweigh the harms, a woman may choose to take tamoxifen. The duration of tamoxifen use in such situations is 5 years based on the results from trials of tamoxifen involving women with early breast cancer. If a woman raises concerns or has already been evaluated and is calculated to be at high risk, then individuals experienced and skilled in counselling may discuss the potential benefits and harms of tamoxifen use. Important additional issues:  Prevention of breast cancer with raloxifene: Current evidence does not support recommending chemoprevention of breast cancer with raloxifene outside of a clinical trial setting.  Screening using the Gail risk assessment index: This index was the main eligibility criterion for enrolling women in the one study that showed potential benefit from chemoprevention. However, it has not been evaluated for use as a routine screening or case-finding instrument; validation of the index is required. Overall, current evidence does not support a shift to its routine use in physicians’ of
Adherence to the Norwegian dietary recommendations in a multi‐ethnic pregnant population prior to being diagnosed with gestational diabetes mellitus

Abstract Maternal diet is a modifiable risk factor for the development of gestational diabetes mellitus (GDM). Even though pregnant women are considered to be motivated to eat healthy, previous research found unhealthy eating patterns among some ethnic and lower socio‐economic status groups. This cross‐sectional study assessed adherence to national dietary recommendations prior to GDM diagnosis in a multi‐ethnic population comprising 237 pregnant women. Participants were diagnosed with GDM after performing a two‐hour oral glucose tolerance test ≥ 9 mmol/L. Participants answered a 41‐item Food Frequency Questionnaire about dietary habits prior to being diagnosed with GDM from October 2015 to March 2018. Their scores were based on adherence to the recommended intake in each food group and summed into a Healthy Diet Score (HDS). Results showed low adherence to national dietary recommendations. A significantly higher proportion of non‐native Norwegian‐speaking women had a high HDS compared with native Norwegian‐speaking women. Participants with a normal prepregnancy weight were more likely to have a high HDS compared with overweight or obese participants. Participants showed low adherence to the recommendations for whole grains, vegetables, and fruits and berries, and a relatively low proportion adhered to the recommendations for intakes of fish, red/processed meat, and ready‐made meals. However, the food group intakes varied by country of birth. Given the increase in women with GDM and the emerging evidence that maternal diet is a modifiable risk factor for GDM, effective nutrition communication strategies in antenatal care are urgently needed.
In-Vitro Fatigue Behavior of Different Materials Used as Frontalis Suspension Slings for Treatment of Blepharoptosis

Author(s): Rohani, Omid Seyed | Advisor(s): Earthman, James C | Abstract: Frontalis suspension is a commonly used surgery that is indicated in patients with droopy eyelids (blepharoptosis) and poor levator muscle function. The surgery is based on connecting the tarsal plate of the droopy eyelid to the frontalis muscle with various slings made either from fascia lata tissue or synthetic materials. However, one of the main complications of this surgery is the high rate of blepharoptosis recurrence, which has been reported for some slings as high as 100%. We initiated a collaborative multidisciplinary research to explore the effect of choice of sling material on this common problem. Two different experimental setups for testing the behavior of various sling materials in-vitro have been developed. Using our first experimental setup, we explored possible gradual permanent elongation of sling materials due to cyclic loading caused by eye blinking. In addition, a more sophisticated second experimental setup was developed to investigate fatigue behavior of different implants under physiologically relevant conditions.We could show that physical changes such as permanent elongation, and holding load drop in the slings could happen under fatigue conditions caused by eye blinking. These changes can contribute to the failure of the frontalis suspension slings and recurrence of blepharoptosis. Our experiments show that different sling materials exhibit significantly different responses. The results of the present study indicate that characterizing the in vitro fatigue behavior of different sling materials can lead to a better understanding of what causes high recurrence rates in frontalis suspension. The characterization methods developed can also be used to improve material selection as well as assist in the development of new materials for this procedure.
Effects of Alternate Weaning Methods on Behavior, Blood Metabolites, and Performance of Beef Calves1

Beef calves traditionally are weaned by abrupt remote separation from their dams. Alternate weaning strategies have been suggested to reduce stress and improve performance of calves after weaning. Two such strategies were compared with abrupt remote separation weaning in spring-born, Angus-crossbred steers. Cow-calf pairs were allotted to 3 treatments 7 d before (d−7 to 0) weaning: fence-line (FL, calves separated from dams by a fence), nose-clips (NC, placement of antisuckling device on calves which then remained with dams), or control (CTRL, calves remained with dams until d 0). All steers were transported away from their dams on d 0, placed on pasture on d 1, and maintained within weaning-method treatment groups. Behavioral observations were conducted from d−7 to−4 and d 1 to 4. The NC calves spent less time eating, more time idling, more time close to dams, walked less, and had reduced ADG compared with FL or CTRL calves before transport (P < 0.05). The CTRL calves spent less time eating, more time idling, and walked more than FL or NC calves (P < 0.05) after transport. Average daily gain of FL calves was greater than NC calves (P < 0.05). On d 0, NC calves had reduced (P < 0.05) creatine kinase and BUN concentrations and greater nonesterified fatty acid concentration. There were no treatment effects for any blood metabolite detected after transport. Nose-clip weaning did not seem to be a comparable method to FL weaning, whereas FL weaning may be an alternative to traditional weaning.
Risk factors for osteoporosis in South Asian and Caucasian postmenopausal women

Objective: There is evidence to show that the risk of osteoporosis is greater for South Asian females compared to Caucasian females. This is due to differences in bone mineral density and other risk factors which contribute to this condition such as calcium and vitamin D intake and exercise levels. The present study set out to examine such differences between these two communities. Postmenopausal females were studied as the risk of osteoporosis is greater after the menopause. Design: Bone mineral density was assessed using the Achilles Insight heel scanner, dietary intake was assessed using a 24 hour recall and lifestyle factors were assessed using a questionnaire. Setting: North West England. Subjects: Total participants 282 Caucasian and 41 South Asian women. Postmenopausal participants – 144 Caucasian and 7 South Asian women. Results: No significant differences were found in bone mineral density between Caucasian and South Asian females, however differences in other risk factors for osteoporosis such as calcium and vitamin D intake were found between the two communities. There were also significant differences in bone mineral density between pre and postmenopausal participants (P<0.001). Conclusions: Although no differences in bone mineral density were found between the two communities, there were significant differences between the pre and postmenopausal participants. This shows how important it is to raise awareness of this public health issue and target other factors associated with osteoporosis in already high risk individuals.
Premenstrual tension syndrome observed in the users of an ambulatory women's health

Many women suffer with Premenstrual Tension Syndrome (STPM) that has symptoms that precede menstruation, causing irritation, anxiety and low self esteem. The STPM affects women in the productive stage causing physical, psychological and social alterations. The aim of the research was to identify the users of an ambulatory health clinic of Tupanciretã, RS. This is a descriptive and exploratory study with qualitative-quantitative approaches. The results provided that women have STPM with different intensity, symptoms range from physical and mental and interfere with daily functioning of women. It was concluded that overall efforts, especially those from health professionals, and through practices which provide communication and health education for women affected by the STPM. In addition to the implementation of actions that provide changing habits, attitudes and behaviors that these women are looking for a better quality of life.
World Health Organizations global targets on maternal, infant and young child nutrition

The World Health Assembly is the supreme decision-making body of the World Health Organization. It meets every year in May in the city of Geneva and is attended by delegations of Member States. The 65th World Health Assembly held from the 21st to 26th of May 2012, approved the Comprehensive Implementation Plan on Maternal, Infant and Young Child Nutrition, which includes six key global targets to achieve improvements in: the stunting (low height for age) in children, anemia in women of reproductive age, low birth weight, overweight in children, exclusive breastfeeding, and wasting in children under five years by the year 2025. These goals were endorsed by the Member States of the World Health Organization who pledged to monitor and track the progress for achievements. The goals help to identify priority areas for action and foster global change. This article describes the six global goals and the tools that are available for adaptation at the national level and for monitoring progress indicators proposed by the Member States. The results of the monitoring tool developed by WHO will be incorporated in the world nutrition report which is being prepared by an independent group of experts. An Venez Nutr 2014; 27(1):26-30.
Dental implant treatment strategies for failing and missing teeth in the maxillary aesthetic region

Failing or missing teeth in the aesthetic region of the maxilla (1st premolar to 1st premolar) create a difficult challenge for patients and dental professionals, because of the aesthetic demands and patient’s expectations. This PhD thesis discusses the complexity of implant treatment in the maxillary aesthetic region (chapter 1). The overall aim of the studies described in this thesis was to assess the outcome of several implant treatment strategies for one or two failing or missing teeth in the maxillary aesthetic region: - Treatment of one failing tooth with immediate implant placement and provisionalization (chapter 2); - Treatment of one failing tooth with immediate implant placement and provisionalization, with or without a connective tissue graft (chapters 3 and 4); - Treatment of two missing teeth with delayed placement of two adjacent implants and single implant-supported restorations (chapter 5); - Treatment of two missing teeth with delayed placement of a single implant and one implant-supported cantilever restoration (chapter 6); - Treatment of two central upper incisors with two adjacent implants and single implant-supported restorations, following a new implant treatment proposal (chapter 7). The results of these studies are discussed in chapter 8. It was concluded that implant treatment for one failing or missing tooth as well as for two adjacent failing or missing teeth in the maxillary aesthetic region results in healthy peri-implant tissues, limited peri-implant bone loss and high patient satisfaction scores, with the exception of the compromised inter-implant papilla that is often seen in case of two adjacent implants.