Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of factors that bring mental effects to elderly people in robot assisted activity

We have developed mental commit robots that can provide psychological, physiological and social effects to human beings through physical interaction. The appearances of these robots look like real animals such as cats and seals. We have applied the mental commit robots to assist activities of the elderly people at a day service center. In order to investigate the effect of the robots on the elderly people, and to analyze the factors that influence them, we evaluated elderly people's mood by questionnaires, and investigated their experience of breeding pets, interaction with the robots and so on. The mental commit robots were introduced at the day service center for five weeks. Results show that the feelings of the elderly people were improved by interaction with the robots. As for the analysis of factors that bring mental effects to the elderly, we found the "time of touch divided by number of touch" in 2/sup nd/ week, and "experiences of breeding pets" in 5/sup th/ week. We conclude that mental commit robots are useful at elderly institutions like the day service center, and the factors of mental effects on elderly people changed from freshness of stimuli of the robots to feelings of breeding the robots like real animals.
The Safety and Efficacy of Clopidogrel in Children with Heart Disease: A Systematic Review

Background: Clopidogrel, an oral antiplatelet, has been used off-label in pediatric patients at risk for thrombosis, including those with heart disease, for more than a decade. While numerous clinical trials in adults have resulted in the formation of comprehensive management guidelines, considerably less is known about the safety and efficacy of clopidogrel use in children. Method: An exhaustive literature search was performed using PubMed, Web of Science, Cochrane, Medline, CINAHL and International Pharmaceutical Abstracts. The keywords searched included “clopidogrel”, “child”, “teen”, “young”, “pediatric”, “boy”, “girl”, “adolescent” and “heart diseases” individually and in combination. The search was limited to the English language and articles older than ten years were excluded. After eliminating duplicate articles and those irrelevant to the topic of interest, seven studies were identified for review and three were selected. Results: Three studies were reviewed, two of which were retrospective chart reviews and one randomized control trial. These studies included children with congenital or acquired heart disease, ages 8 days to 18 years old. Doses varied by study from 0.01 mg/kg/day to 6 mg/kg/day. Very few thrombotic events occurred and these events were rarely attributed to clopidogrel. The most frequent complication was skin bruising and minor bleeding. Conclusion: Clopidogrel appears to be relatively well tolerated in infants and children at low doses, but should be used cautiously, particularly when administered in combination with other antiplatelet or anticoagulants, as it may increase bleeding risks.
Molecular Mechanisms Responsible for Malignant Transformation by Regulatory and Catalytic Domain Variants of the Interferon-induced Enzyme RNA-dependent Protein Kinase (*)

Double-stranded RNA-dependent protein kinase (PKR) is suggested to play an important role in both the antiviral and antiproliferative arms of the interferon response. To gain insights into the molecular mechanisms underlying PKR's growth regulatory properties, we examined the biological and biochemical properties of PKR variants containing either a mutation in catalytic domain II (PKR-M1) or a deletion of RNA binding domain I (PKR-M7) in both reticulocyte translation extracts and in vitro kinase assays with purified reagents and compared these results with those using the same mutants stably expressed in vivo. While wild-type PKR (PKR-WT) efficiently inhibited mRNA translation in a reticulocyte extract, the inactive PKR-M1 had no effect. The PKR-M7 mutant was modestly inhibitory in this assay. The PKR-M1 variant was able to reverse the translational inhibitory effects and increased eukaryotic initiation factor (eIF)-2α phosphorylation levels caused by addition of double-stranded RNA to reticulocyte extract, whereas PKR-M7 could not. Both PKR-M1 and PKR-M7 functioned as transdominant inhibitors of PKR-WT in our in vitro kinase assays. While the inhibition by PKR-M1 required a vast excess of mutant to shut down PKR function, PKR-M7 inhibited PKR-WT at approximately stoichiometric levels. To complement these experiments, we compared growth rates and α phosphorylation levels in transformed cell lines overexpressing either PKR-M1 or PKR-M7. Levels of endogenous eIF-2α phosphorylation were significantly more diminished in PKR-M7 overexpressing cells compared with PKR-M1. These paradoxical data will be discussed in terms of the potential molecular mechanisms underlying malignant transformation caused by the PKR variants.
VIRTUAL REALITY IN PHYSICAL REHABILITATION OF PATIENTS WITH PARKINSON ’ S DISEASE

A new epidemiological profile occurs due to the aging of population. This profile generates an increase in chronic and degenerative diseases. Parkinson’s disease (PD) is one with a higher incidence in elderly people1. It is estimated that, in 2020, more than forty million people around the world will develop PD2. People older than 55 years old are most affected by this disease and it is clinically characterized by bradykinesia and, at least one of the following signs: rest tremor, rigidity and, at a later date, postural instability3. According to the progressive evolution of this disease, patients tend to reduce the quantity and variety of their activities and consequently, a reduction in physical fitness4. For this reason, drugs and physical therapies are indicated in PD. It has also been hypothesized that physical activity performed in Abstract
Diagnostic Case Studies of the Northern Annular Mode

Abstract Recent observational studies of the northern annular mode (NAM) indicate that significant case-to-case variability exists in the structural evolution of individual events. In particular, certain NAM events remain confined to stratospheric altitudes whereas others readily penetrate downward into the troposphere. We perform observational diagnostic analyses that are targeted at identifying the physical mechanisms behind this distinction. Our results thereby provide a test of the different existing theories regarding stratospheric influences upon tropospheric climate. We contrast robust stratospheric NAM events with differing tropospheric signals in order to identify the underlying dynamical reasons for the observed differences. Piecewise potential vorticity (PV) inversions and Eliassen–Palm flux analyses are performed to study the roles of different forcing mechanisms during NAM onset. Our results indicate that variations in the tropospheric response are readily explained on the basis of piecewise .
Renal consequences of salt and hypertension.

S ALT HAS BEEN known to civilization since ancient times. The sacrificial use of salt is mentioned in Matthew. Plato named it a “substance dear to the Gods,” whereas Homer called salt “divine. ” In ancient Rome, salt was used as payment for the soldiers of the Roman legions, and in fact the root of the word salary is derived from the same root as the word salt. The notion that salt may effect blood pressure is found as far back as 2600 B.C. The classic Chinese text of medicine, Neiching, describes a “hardening of the pulse” associated with high sodium intake. As an additive to food, salt has been known for millennia, however, it was an uncommon practice until relatively modern times. In 1904 Ambard and Beaujard observed that dietary sodium intake may indeed have an effect on human hypertension. ’ We have endeavored to review here the current concepts relating to the effects of dietary sodium upon arterial hypertension.
METIONINA E LISINA NO DESENVOLVIMENTO DE FRANGOS DE CORTE

Estudou-se, atraves do rendimento de carcaca de frango de corte, linhagem em desenvolvimento no CNPSA-EMBRAPA, as exigencias de metionina e lisina na dieta. Os tratamentos consistiram de 6 niveis crescentes de metionina (0,27; 0,35; 0,43; 0,51; 0,59 e 0,67 %) e de lisina (0,9; 1,0; 1,1; 1,2; 1,3 e 1,4 %), na fase 1, periodo de 1 a 21 dias de idade e de (0,25; 0,32; 0,39; 0,46; 0,53 e 0,60 %) e (0,7; 0,8; 0,9; 1,0; 1,1 e 1,2 %), respectivamente, na fase 2, correspondendo ao periodo de 22 a 42 dias de idade de desenvolvimento dos frangos. As estimativas dos niveis de exigencia foram obtidas atraves do modelo de regressao da linha quebrada. A exigencia de metionina foi de 0,44 % nas duas fases, para ambos os sexos. Para lisina a exigencia foi de 1,03 % na fase de 1 a 21 dias para ambos os sexos, sendo de 0,86 e 0,78 %, na fase de 22 a 42 dias, para machos e femeas, respectivamente. A proteina bruta (PB) do frango aumentou tanto com a concentracao da metionina como da lisina na dieta . A adicao de lisina melhorou linearmente o rendimento de peito. Nao houve efeito significativo dos aminoacidos nos outros cortes analisados, bem como na gordura abdominal. Niveis mais elevados de lisina diminuiram o teor de Extrato Etereo(EE) da carcaca.
Biological Air Contamination in Elderly Care Centers: Geria Project

Indoor air quality (IAQ) affects health particularly in susceptible individuals such as the elderly. It has been estimated that the older population spends approximately 19–20 h/d indoors, and the majority of the elderly spend all of their time indoors in elderly care centers (ECC). Older individuals may be particularly at risk of exposure to detrimental effects from pollutants, even at low concentrations, due to common and multiple underlying chronic diseases that increase susceptibility. This study, aimed to assess the impact of indoor biological agents in 22 ECC located in Porto, was conducted during summer and winter from November 2011 to August 2013 at a total of 141 areas within dining rooms, drawing rooms, medical offices, and bedrooms (including the bedridden). Air sampling was carried out with a microbiological air sampler (Merck MAS-100) and using tryptic soy agar for bacteria and malt extract agar for fungi. The results obtained were compared with the recently revised Portuguese standards. In winter, mean fungi concentration exceeded reference values, while bacteria concentrations were within the new standards in both seasons. The main fungi species found indoors were Cladosporium (73%) in summer and Penicillium (67%) in winter. Aspergillus fumigatus, Aspergillus niger, and Aspergillus flavus, known potential pathogenic/toxigenic species, were also identified. Although the overall rate and mean values of bacteria and fungi found in ECC indoor air met Portuguese legislation, some concern is raised by the presence of pathogenic microorganisms. Simple measures, like opening windows and doors to promote air exchange and renewal, may improve effectiveness in enhancing IAQ.
Second-harmonic microscopy of biological tissue.

We present the first reported optical second-harmonic microscope images of a biological sample—rattail tendon—and discuss, also for the first time, the need to distinguish between coherent and incoherent second-harmonic imaging. Our data show that the currently unexplained macroscopic polar order of this classic representative of connective tissue is due both to a coherent network containing a large number of fine, polar, filamentlike structures that permeate the entire tendon volume and to a small number of intensely polar surface patches.
First record of the Lesser Snouted Treefrog Scinax nasicus ( Cope , 1862 ) in Brazilian coast and new species records for the state of Rio Grande do Sul

Herein, we provide new occurrence records of Scinax nasicus (Cope, 1862) for the state of Rio Grande do Sul, Southern Brazil. All new records here provide are located on Southern half of the state. Besides this, we provide the first record for species in Brazilian coastal zone. Those records improve considerably our knowledge regarding species distribution in Southern Brazil.
Android malicious code Classification using Deep Belief Network

This paper presents a novel Android malware classification model planned to classify and categorize Android malicious code at Drebin dataset. The amount of malicious mobile application targeting Android based smartphones has increased rapidly. In this paper, Restricted Boltzmann Machine and Deep Belief Network are used to classify malware into families of Android application. A texture-fingerprint based approach is proposed to extract or detect the feature of malware content. A malware has a unique "image texture" in feature spatial relations. The method uses information on texture image extracted from malicious or benign code, which are mapped to uncompressed gray-scale according to the texture image-based approach. By studying and extracting the implicit features of the API call from a large number of training samples, we get the original dynamic activity features sets. In order to improve the accuracy of classification algorithm on the features selection, on the basis of which, it combines the implicit features of the texture image and API call in malicious code, to train Restricted Boltzmann Machine and Back Propagation. In an evaluation with different malware and benign samples, the experimental results suggest that the usability of this method---using Deep Belief Network to classify Android malware by their texture images and API calls, it detects more than 94% of the malware with few false alarms. Which is higher than shallow machine learning algorithm clearly.
Incorporating activity-travel time uncertainty and stochastic space–time prisms in multistate supernetworks for activity-travel scheduling

Multistate supernetwork approach has been advanced recently to study multimodal, multi-activity travel behavior. The approach allows simultaneously modeling multiple choice facets pertaining to activity-travel scheduling behavior, subject to space–time constraints, in the context of full daily activity-travel patterns. In that sense, multistate supernetworks offer an alternative to constraints-based time-geographic activity-based models. To date, most research on time-geographic models and supernetworks alike has represented time and space in a deterministic fashion. To enhance the validity and realism of the scheduling process and the underlying space–time decisions, this paper pioneers incorporating time uncertainty in multistate supernetworks for activity-travel scheduling. Solutions based on the concept of the -shortest path are proposed to find the reliable activity-travel pattern with confidence level. An algorithm combining label correcting and Monte-Carlo integration is proposed to finding the-shortest paths in the presence of time window constraints. An example of a typical daily activity program is executed to demonstrate the applicability of the proposed extension.
Anti-Viral Drugs for Human Adenoviruses

There are many stages in the development of a new drug for viral infection and such processes are even further complicated for adenovirus by the fact that there are at least 51 serotypes, forming six distinct groups (A–F), with different degree of infectivity. This review attempts to address the importance of developing pharmaceuticals for adenovirus and also review recent development in drug discovery for adenovirus, including newer strategies such as microRNA approaches. Different drug screening strategies will also be discussed.
A New Approach to the Evaluation of Forming Limits in Sheet Metal Forming

The forming limit diagram (FLD) is at the moment the most important method for the prediction of failure within sheet metal forming operations. Key idea is the detection of the onset of necking in dependency of different sample geometry. Whereas the standardized evaluation methods provides very robust and reliable results for conventional materials like deep drawing steels, the determined forming limits for modern light materials are often too conservative due to the different failure behavior. Therefore, within this contribution a new and innovative approach for the identification of the onset of necking will be presented. By using a pattern recognition-based approach in combination with an optical strain measurement system the complete strain history during the test can be evaluated. The principal procedure as well as the first promising results are presented and discussed.
Efficacy of chlorinated and ozonated water in reducing Salmonella typhimurium attached to tomato surfaces

Abstract The purpose of this study was to compare chlorinated and ozonated water in reducing Salmonella typhimurium inoculated onto fresh ripe tomatoes. Surface-inoculated tomatoes were immersed/sprayed with chlorinated (200 mg l−1) and ozonated water (1 and 2 mg l−1) under 2 and 100 nefelometric turbidity units (NTU). Contact times were 120 and 30 s for immersing and spraying applications, respectively. Immersing in chlorinated water and low turbidity resulted in the most effective application with 3.61 log10 bacterial reduction, while 1 and 2 mg l−1 of ozone reduced 2.32 and 2.53 log10, respectively. High turbidity and chlorine reduced the bacterial counts by 3.39 log10, while 1 and 2 mg l−1 of ozonated water and low turbidity reduced the bacteria by 1.48 and 1.92 log10, respectively. Spraying chlorinated water reduced bacteria by 3 log10, and ozonated water at 1 and 2 mg l−1 reduced counts by 1.84 and 2.40 log10, respectively. No statistical differences were found between chlorine and ozone (2 mg l−1) during spraying applications (p < 0.05). The use of ozonated water both in immersing and spraying applications is suggested when water turbidity remains low.
Orbital magnetic moments of Co in multilayers with perpendicular magnetic anisotropy.

The out-of-plane orbital magnetic moment of Co in Co/[ital X] multilayers ([ital X]=Pd, Pt, and Ni) with perpendicular magnetic anisotropy has been investigated using x-ray magnetic-circular-dichroism spectroscopy. The orbital [ital d] moment per Co atom, [ital m][sub orb][sup [perpendicular]], is considerably enhanced by (0.15[plus minus]0.02)[mu][sub [ital B]] and (0.07[plus minus]0.02)[mu][sub [ital B]] in Co/Pd and Co/Pt multilayers, respectively, compared with a single thick Co film. No respective enhancement is found in the case of Co/Ni. This enhancement does [ital not] scale with the spin-orbit coupling parameter [xi][sub SO] of Ni-3[ital d], Pd-4[ital d], and Pt-5[ital d] bands despite strong [ital d]-[ital d] mixing which leads to the presence of ferromagnetic moments of Pd and Pt atoms. However, a roughly linear scaling relation of the out-of-plane orbital moment [ital m][sub orb][sup [perpendicular]] with the intrinsic uniaxial anisotropy constant [ital K][sub [ital u],1][sup Co] per Co volume is observed. This experimental finding is interpreted in conjunction with recent [ital ab] [ital initio] and tight-binding band-structure calculations as evidence for a preferential enhancement of the out-of-plane orbital moment of Co in Co/Pd and Co/Pt multilayers.
Genetic methods for detection of antimicrobial resistance

Accurate and rapid diagnostic methods are needed to guide antimicrobial therapy and infection control interventions. Advances in real‐time PCR have provided a user‐friendly, rapid and reproducible testing platform catalysing an increased use of genetic assays as part of a wider strategy to minimize the development and spread of antimicrobial‐resistant bacteria. In this review we outline the principal features of genetic assays in the detection of antimicrobial resistance, their advantages and limitations, and discuss specific applications in the detection of methicillin‐resistant Staphylococcus aureus, glycopeptide‐resistant enterococci, aminoglycoside resistance in staphylococci and enterococci, broad‐spectrum resistance to β‐lactam antibiotics in gram‐negative bacteria, as well as genetic elements involved in the assembly and spread of antimicrobial resistance.
Viral Hepatitis in Mongolia : Past , Present , and Future

Infection with hepatitis A virus (HAV) is one of the common causes of liver disease of great public health importance in the world. However, the level of endemicity, the median age at the time of infection, and the frequency of clinically apparent hepatitis caused by HAV vary by population.1 The seroprevalence rate of HAV is highly correlated with the socioeconomic status and access to clean water and sanitation. Mongolia, one of the developing countries in Asia, has been considered to be highly endemic for HAV infection. However, there have been little or no data on the serological and molecular epidemiology of HAV infection among children in Mongolia. The overall prevalence of anti-HAV among apparently healthy persons aged 0 to 20 years was found to be 68.9%, and the age dependency of HAV seroprevalence was noted. All but 1 of the 15 neonates 7 to 28 days of age had anti-HAV. The mother of the infant who was negative for anti-HAV was 19 years old, and the absence of anti-HAV in this infant may have been due to the lack of anti-HAV in the maternal antibodies (i.e., lack of anti-HAV in cord blood and colostrum). The prevalence of anti-HAV decreased to 72.7% in the age group 1 to 2 months, 50% in the age group 3 to 4 months, and 25.0% in the age group 5 to 6 months, and reached 0% in infants aged 7 to 11 months, suggesting the gradual disappearance of pasMINI REVIEW 10.5005/jp-journals-10018-1168
“Lowe syndrome: A particularly severe phenotype without clinical kidney involvement”

Lowe syndrome (LS) is a very rare disorder of phosphatidylinositol metabolism, which manifests with a complex phenotype comprising a clinical triad encompassing major abnormalities of the eyes, the kidneys, and the central nervous system. We are reporting a 23‐year‐old Egyptian male with a severe phenotype of LS with a minimal kidney disease. Direct sequencing of the OCRL gene detected a p.His375Arg mutation in the catalytic domain of the protein. The patient suffered from bilateral congenital cataracts and glaucoma, striking growth deficiency, severe psychomotor disability, a severe osteopathy, and seizures, but only minimal renal dysfunction. Although the biological mechanisms underlying the pathophysiology of LS manifestations is yet unclear, it has been proposed that growth delay and osteopathy are linked to a renal dysfunction. This report, however, argues this association and suggests that kidney dysfunction may partially explain the growth deficiency and bone abnormalities, but other still undefined factors might have a potential impact.