Miracle-dz/UniFAR-FTUs huggingface dataset:
Transformation of education in the conditions of digitalization

Purpose of the study is carrying out the analysis of current trends in education in the conditions of digitalization. In the put modern economic and technological conditions new modern approaches to development of key competences of digital economy, ensuring mass digital literacy of experts and personalisation of educational process are required. For realization of the specified purpose the passport of the Federal project “Shots for Digital Economy” is approved on May 28, 2019. According to target indicators of the Project by 2024 have to be trained on online to programs of development of digital literacy; 120 thousand people have to be accepted on training in programs of the higher education in the sphere of information technologies; about 8 programs of the higher education for the benefit of digital economy are created. The research problem – to establish as far as realizuyema goals.Materials and methods. For the purpose of the description of the current situation methods of descriptive statistics are used. The analysis of information collected during the sociological poll organized and held by PPS of department of statistics together with ANO Council for Questions of Management and Development at Department of work and social protection of the population of the city of Moscow is provided. Methods of visualization of data are applied to evident data presentation. Data processing was carried out with application of MS of Excel and a package of the IBM SPSS Statistics application programs.Results. The carried-out analysis allowed to define top trends in education. The revealed trends proved need of improvement of quality of education with application of information and communication technologies. Results of a research show about demand in labor market of experts in the sphere of information and communication technologies, including among persons with limited opportunities. The world rankings testify to low positions of Russia on the level of involvement of the experts having the specified skills.Conclusion. At the same time, the programs implemented by the state in education will allow to build a qualitative education system at all levels, including both support of talented youth in mathematics and informatics, and training of the highly qualified personnel conforming to new requirements of digital economy and also programs of retraining and professional development for the most demanded professions.
Large Cell Neuroendocrine Carcinoma (LCNEC) of the Colon Arising from a Tubulovillous Adenoma: A Case Report and Literature Review

A 66-year-old man was found to have a 4 cm mass in the distal transverse colon that was biopsied on a diagnostic colonoscopy performed for occult anemia. Pathology showed incomplete removal of a tubulovillous adenoma with high-grade dysplasia. The patient underwent surgical resection, with final pathology demonstrating two 5 mm foci of large cell neuroendocrine carcinoma (LCNEC) within a background of tubulovillous adenoma, and 1 of 8 positive lymph nodes. Poorly-differentiated neuroendocrine tumors (NET) are termed neuroendocrine carcinoma (NEC), and are extremely rare. Colorectal LCNEC have been identified in synchronicity or association with adenomas and adenocarcinomas (AC). There are several theories that attempt to explain the pathogenesis of colorectal tumors with concurrent neuroendocrine and adenomatous pathology: (1) mixed tumors are a neuroendocrine phenotype of dedifferentiated adenocarcinoma; (2) these tumors originate from a common multipotent stem cell then simultaneously differentiate into glandular or neuroendocrine lineages; or, (3) a common genetic alteration predisposes an individual to the development of both tumor types. More work is needed to delineate the true pathogenesis of colorectal tumors with concurrent neuroendocrine and adenomatous pathology. There are no agreed-upon management guidelines for colorectal NEC, although given its highly aggressive nature, standard oncologic resection and adjuvant platinum-based chemotherapy are generally recommended for patients with resectable disease.
Aerobic high intensity interval training is an effective treatment for patients with Chronic Obstructive Pulmonary Disease

The purpose of this study was to investigate whether individual leg cycling could produce higher whole body peak oxygen uptake (VO(2peak)) than two legs cycling during aerobic high intensity interval training in chronic obstructive pulmonary disease (COPD) patients. Nineteen patients trained in 24 supervised cycling sessions either by one leg training (OLT) (n = 12) or by two legs training (TLT) (n = 7) at 4 x 4 min intervals at 85-95% of peak heart rate. Whole body VO(2peak) and peak work rate increased significantly by 12 and 23% in the OLT, and by 6 and 12% in the TLT from pre- to post-training, respectively, and were significantly greater in the OLT than the TLT (P < 0.05). The present study demonstrates that one leg aerobic high intensity interval cycling is superior to two legs in increasing whole body VO(2peak), indicating a muscle rather than a cardiovascular limitation to VO(2peak) in these COPD patients.
Early prediction of some kid body dimensions from maternal traits

This study was conducted in the Iraqi Ministry of Agriculture, Ruminant Research Station, west of Baghdad. It included 447 goats born of both sexes belonging to local, Shami and their crosses. The body dimensions of kids at birth and the dam's weight and age at birth, as well as the dependence of weaning weight on the birth weight of the kids by the use of simple linear regression equations. The results presented that coefficient of regression of most studied dimensions on the traits of maternal weight at birth and weight of the kid at birth has significant effect, except the regression of the body length at birth on both the maternal weight at birth and the kids weight at birth, which was not significant, The results showed the possibility of dependence on the studied maternal characteristics and kids birth weight to predict the dimensions of the goat kids body at birth.
Local knowledge of pumpkin production, performance and utilization systems for value addition avenues from selected agro-ecological zones of Uganda

Pumpkin is one of the underutilized fruit vegetables in Uganda despite the fact that it has wide spectrum of both nutritional and medicinal values. A survey was carried out to document local knowledge of pumpkin production; performance and utilization systems to aid the selection of pumpkin varieties to be used for particular value addition avenues. It was observed that twelve varieties of pumpkin are commonly grown and they are mainly distinguished by their skin colour, texture of epicarp and shape. Pumpkin production levels on large scale, small scale and subsistence were at 27.8, 66.7 and 5.6% respectively. Farmers reported that ‘pumpkin seeds are usually sown directly into the main garden;’ thus, nursery beds are rarely used by the farmers. Farmers appreciate the crop’s nutritional and medicinal values, in addition to being a source of livelihood. Pumpkin fruit vegetable is multi-purpose in that all the parts of the plant can be consumed thus minimizing food wastage and also the plant can stay long on the shelf thus has the potential to act as a food security crop. From the survey, it was observed that mostly elderly people above 46 years were involved in pumpkin cultivation; youths were less involved and pumpkin cultivation is mainly practiced on a small scale. The youths need to be educated and encouraged to get involved in pumpkin cultivation since it can reduce poverty levels, food insecurity and malnutrition. Key words: Agro-ecological zone, local knowledge, medicinal value, nutritional value, pumpkin, variety.
The MNE headquarters-subsidiary relationship, subsidiary strategy and performance : an empirical examination in China

Since 2010, China has become the second largest economy in the world, providing a more attractive environment for enterprises doing business than most other countries. Many multinational enterprises (MNEs) have set up subsidiaries to seek resources and opportunities in China. Since there are often cultural and institutional differences between home and host countries, MNEs usually face some management problems when doing business in a host country. How to develop corporate strategy to better support subsidiary performance becomes an important question for MNEs entering developing countries like China. Given Chinaâ€™s unique business environment, MNEs face many challenges in adapting to this local marketplace. They need time to develop and apply local capacity, such as relational networks, namely guanxi. They also need to determine the entry mode according to the social system of China. Finally, one of the most important questions for an MNE entering China is how to design its subsidiary strategy. This research seeks to identify the mechanisms that influence the operating performance of MNE subsidiaries in host countries. It addresses the following questions: (1) How does the MNE subsidiary strategy develop and what are the main influencing factors? (2) How is an MNEâ€™s China subsidiary strategy influenced by its international business strategies and vice versa? (3) How is the subsidiaryâ€™s performance affected by the subsidiary strategy and why? (4) How does the MNEâ€™s headquarters-subsidiary relationship and headquarters control mediate the process and why? To answer these questions, strategic contingency theory is applied to study the effect of the headquarters-subsidiary relationship on subsidiary strategy and performance. The object of this qualitative research is an international corporation, UST Group of companies. The findings are summarized in the form of a framework which shows that (1) the MNEâ€™s internal and external environments, i.e. the host market conditions, competitors, institutions and uncertainties, tend to directly influence its subsidiary strategy; (2) the MNEâ€™s environment can also influence subsidiary strategy indirectly through the relationship between the headquarters and the subsidiary, which means that the headquarters-subsidiary relationship acts as a mediator between environment and subsidiary strategy; (3) forms of informal control such as flexible control and personal connections significantly affect subsidiary strategy and performance in China; (4) the subsidiaryâ€™s strategy, particularly its strategic motives, entry strategy and human resource management, tend to influence its financial and non-financial performance in the host country. The main conclusions are: (1) MNE environment is the principal factor to be considered when entering a host country; (2) subsidiary strategy is determined by the MNE environment and headquarters-subsidiary relationship; (3) the MNE environment influences the subsidiary environment through the headquarters-subsidiary relationship. The managerial…
Pain Management, Coping with Stress, and Quality of Life for Women with Fibromyalgia: A Qualitative Case Study

Fibromyalgia (FM) is a chronic illness characterized by pain that spreads throughout the body, accompanied by other symptoms. In general, fibromyalgia sufferers experience fatigue, mood disorders, dizziness, sleep disturbances, and difficulty in concentrating. Other symptoms are also often found in people with fibromyalgia, such as impurity, headaches, and intestinal irritation. Individuals with fibromyalgia are usually reported to have a decreased quality of life, decreased functioning status, and make greater demands on health services. This study was conducted using qualitative methods for pain management, coping with stress, and quality of life for women with fibromyalgia. In addition, this research can help provide an overview of fibromyalgia sufferers as the illness relates to psychological conditions and efforts to overcome changes that occur both physically and psychologically. The method used was in-depth interviews conducted on five women with fibromyalgia with an age range of 25–55 years.
Using Workshops to Improve Instruction in STEM Courses

Workshops are currently one of the most popular ways for instructors in STEM fields to learn more about teaching and learning. Yet research shows we often do not know what participants gain from attending. This article suggests ways of measuring impact of instructional improvement workshops that will help not only workshop providers with designing better workshops but also prospective participants with choosing workshops wisely.
Examining the response of Escherichia coli and Pseudomonas aeruginosa to organic acid stress.

Weak organic acids have been used for centuries to treat infections and preserve food. However, the detailed mechanisms by which they exert their effect on the cell are not fully understood. Two aspects of organic acid action are presented in this thesis. In the first study, a combination of transcriptomics, transposon-insertion sequencing (TraDIS) and evolution were used to probe the molecular mechanism by which acetic, propionic and butyric acid at both neutral and mildly acidic pH affect cellular process in the UPEC strain E. coli EO499. The effects were numerous and complex, with all three organic acids having a large impact on metabolic processes. Six populations of EO 499 evolved independently at pH 5.5 with 4 mM acetic acid showed increased fitness in that environment, but that fitness was not replicated in an environment of pH 5.5 alone. A cross-comparison of the data derived from these different approaches reveals a highly complex network of genes and responses which are not easily interpreted. Comparison of the methods revealed some overlap between the TraDIS and RNAseq data, with a large proportion of the genes which were considered significant in TraDIS also showing differential regulation. This indicates that with more sophisticated bioinformatics techniques, it should be possible to build up intricate networks of the response to organic acids. The second study examined the inhibition of growth and biofilm formation in P. aeruginosa PA01 and a clinical isolate PA1054 by a range of organic acids. This study was devised to help inform the use of organic acids as a topical treatment for burn wounds. A laboratory plate reader was used to generate growth data in eight different organic acids at three different concentrations and five different pH. This data was then analysed (in collaboration with colleagues) using three mathematical approaches, two parametric and one Bayesian. The plates used for growth were also stained to quantify biofilm formation. This study found that the most effective acid at inhibiting both growth and biofilm formation was propionic acid and the least effective was benzoic acid. The effects of all acids were significantly enhanced by reduction in pH. These data indicate that the use of organic acids as a topical treatment would likely inhibit wound infections. However, the currently used concentrations of ~800 mM could be reduced if combined with mildly acidic solution.
Natural products: An emerging tool in parkinson’s disease therapeutics

Parkinson’s disease is a age associated chronic neurodegenerative disorder of central nervous system characterized by selective loss of dopaminergic neurons in substaintia nigra pars compacta which causes functional impairment of midbrain. Although the cause of PD is still not known, but there are several factors such asoxidative stress, genetic mutations, mitochondrial dysfunction, aggregationprotein specifically αsynuclein and neuroinflammation play apivotal role in pathogenesis of PD. The current treatment primarily includes dopaminergic and non-dopaminegic medications which only provides symptomatic relief and when drug therapy is fails to provide relief, the next step is surgical treatments. Unfortunately the current regimens have certain limitations with multiple side effectsand possess economic burden thus, there is a need to discovered new therapeutic approaches which have antiparkinsonial potential and minimum adverse effects. For many years, some phytoconstituents from natural products have provided an competent resource for the revelation of potential therapeutic agents. The anti-PD potential of these phytoconstituents is because of their well apperceived anti-oxidative, anti-inflammatory activities, their repressive role on agreegation of protein and the regulatory effects of PD cognate pathways. The intention of this review article is to cover the potential of phytoconstituents against the neurodegeneration intangle in PD and to encourage the improvement in future novel treatment strategies predicated on natural sources. © 2019 Published by Innovative Publication.
GRChat: A Contact-based Messaging Application for the Evaluation of Information Diffusion

—Contact-based messaging applications establish a short-range communication directly between mobile devices, storing the messages in the devices in order to achieve a full dissemination of such messages. When a contact occurs, the mobile devices interchange their stored messages, following a epidemic diffusion. No messages are sent or stored in servers. In order to evaluate the diffusion of messages among mobile devices based on opportunistic contacts, we developed GRChat, an Android application that uses Bluetooth as near-by communication protocol. We present some results about the efﬁciency of peer-to-peer message diffusion depending on message size and devices distance.
RETRIEVAL INTERFACES FOR SUPPORTING EXPLORATORY SEARCHES

Many search engines do not effectively support searches with imprecise or open information needs, such as in the case for exploratory video searches. The information seeker’s lack of domain knowledge in exploratory searches convolutes the search process. Search interfaces are generally developed to support high-level search activities like query formulation. The purpose of this study is to gather ideas and opinions from experts from different fields to develop design concepts and interface features for exploratory video search interfaces. The findings suggest that visual maps can be used to present the structure of the domain of interest and to support exploration of the concept of interest. These maps also support knowledge construction and hence aid in the extension of concepts in the search.
The ageing sensorimotor control system and falls in the elderly

During ageing, degeneration undergoes at all levels of the sensorimotor system and causes unfavourable consequences, including falls. Falls are the predominant cause of unintentional injuries in the elderly and constitute a significant threat to our ageing societies. While extensive research on falls has been done, the relationship between sensorimotor variability, sensorimotor control and falls in elderly has not been investigated. We hypothesise that both sensory and motor noise increases with age and results in more variable movement. This leads to a higher probability of trips while walking, the main causes of falls in the elderly. My research uses motor and sensory psychophysics and computational modelling to characterise sensorimotor variability across age. I pinpoint specific system changes that cause it. Crucially, the experimental tasks we design and use have shared biomechanics of walking and obstacle avoidance and can, therefore, be referred to observed age-related changes in human locomotion. I show that sensorimotor variability in foot placement increases with age and the degree of increase positively correlates with higher foot placement. Sensory psychophysics indicates that increased sensory noise is one cause underlying more variable movement in ageing. Notably, elderly participants rely more on their vision to judge their own foot’s height compared with the young. This could be related to their impaired proprioception. Thus, the multi-sensory integration strategy shifts with age to compensate for increased sensory noise. By developing and using a simple but powerful cortico-spinal-motor model, I also demonstrate that an increase of motor noise in ageing can well be explained by motor neuron loss in the primary motor cortex. In summary, my results provide a first computational and psychophysics driven investigation into how increased sensory and motor noise can lead to falls in the elderly.
Inbreeding depression in Holstein cattle in Brazil

ABSTRACT The objective of this study was to evaluate inbreeding depression in Holstein cows in Brazil, considering their 305-day milk production (MP), age of first calving (AFC), and calving interval (CI). The effects of inbreeding depression on the traits were determined using four regression models (linear, quadratic, exponential, and Michaelis-Menten) about the errors generated by the animal model. The linear model was significant for CI, and the quadratic model was significant for CI and AFC. The Michaelis-Menten and exponential models [. ]
Effects of the tenants electricity law on energy system layout and landlord-tenant relationship in a multi-family building in Germany

Multi-family buildings (MFB) accommodate 53% of the German apartment stock. Although PV-systems on single-family buildings are widely implemented, the PV-potential on MFBs has barely been touched. Therefore, the German government introduced the Mieterstromgesetz, the tenants electricity law (TEL), in 2016. This law exempts electricity directly produced and consumed in a building from certain charges and taxes. Within the TEL framework, the landlord acts as the local electricity provider and can profit from selling electricity to the tenants and tenants can save electricity costs. This paper analyses the techno-economic effects of the TEL on the energy system layout of a MFB in Germany. Furthermore, it gives implications on how the TEL affects the tenant-landlord relationship. In this analyses, a MILP model is used to maximize the net present value (NPV) and determines the optimal layout and dispatch of the energy system. The model can choose to invest in PV, CHP and a battery storage system. Additionally, one to six electric vehicles (EVs) are integrated into the model. The novelty of this paper is the model-based analysis of the German Mieterstromgesetz considering EVs. The results show that the combination of PV and CHP is the most profitable system layout with NPVs up to 31.9ke. An optimized charging strategy increases the self-consumption rate and the NPV substantially compared to a fast-charging-strategy. Thus, the TEL can create a symbiotic relationship between landlords and tenants.