Miracle-dz/UniFAR-FTUs huggingface dataset:
WINNER: A network biology tool for biomolecular characterization and prioritization

Background and contribution In network biology, molecular functions can be characterized by network-based inference, or “guilt-by-associations. ” PageRank-like tools have been applied in the study of biomolecular interaction networks to obtain further the relative significance of all molecules in the network. However, there is a great deal of inherent noise in widely accessible data sets for gene-to-gene associations or protein-protein interactions. How to develop robust tests to expand, filter, and rank molecular entities in disease-specific networks remains an ad hoc data analysis process. Results We describe a new biomolecular characterization and prioritization tool called Weighted In-Network Node Expansion and Ranking (WINNER). It takes the input of any molecular interaction network data and generates an optionally expanded network with all the nodes ranked according to their relevance to one another in the network. To help users assess the robustness of results, WINNER provides two different types of statistics. The first type is a node-expansion p-value, which helps evaluate the statistical significance of adding “non-seed” molecules to the original biomolecular interaction network consisting of “seed” molecules and molecular interactions. The second type is a node-ranking p-value, which helps evaluate the relative statistical significance of the contribution of each node to the overall network architecture. We validated the robustness of WINNER in ranking top molecules by spiking noises in several network permutation experiments. We have found that node degree–preservation randomization of the gene network produced normally distributed ranking scores, which outperform those made with other gene network randomization techniques. Furthermore, we validated that a more significant proportion of the WINNER-ranked genes was associated with disease biology than existing methods such as PageRank. We demonstrated the performance of WINNER with a few case studies, including Alzheimer's disease, breast cancer, myocardial infarctions, and Triple negative breast cancer (TNBC). In all these case studies, the expanded and top-ranked genes identified by WINNER reveal disease biology more significantly than those identified by other gene prioritizing software tools, including Ingenuity Pathway Analysis (IPA) and DiAMOND. Conclusion WINNER ranking strongly correlates to other ranking methods when the network covers sufficient node and edge information, indicating a high network quality. WINNER users can use this new tool to robustly evaluate a list of candidate genes, proteins, or metabolites produced from high-throughput biology experiments, as long as there is available gene/protein/metabolic network information.
Book Reviews - Rezensionen

Р. Ю. Данилевский. Фридрих Шиллер и Россия. СПб. : Издательство «Пушкинский Дом», 2013. -656 с. (Сер.: Библиотека Пушкинского Дома). (Aleksandra Toickina) Ф. М. Достоевский. Полное собрание сочинений и писем в тридцати пяти томах. 2-е издание, исправленное и дополненное. Санкт- Петербург, «Наука». 2013-2014. Т. 1-3. (Aleksandra Toickina) Н. Ф. Буданова. «И свет во тьме светит…» (К характеристике мировоззрения и творчества позднего Достоевского). СПб. : ИД «Петрополис», 2012. -408 с. (Aleksandra Toickina) В. А. Туниманов. Лабиринт сцеплений. Избранные статьи / Отв. ред. С. Н. Гуськов; составители Н. Л. Сухачев, С. Н. Гуськов; вступитель- ная статья Н. Л. Сухачева и М. В. Отрадина. – СПб. : Издательство «Пушкинский Дом», 2013. - 592 с. (Aleksandra Toickina)
High genotypic diversity of the reef-building coral Porites lobata (Scleractinia: Poritidae) in Isla del Coco National Park, Costa Rica

The isolated Isla del Coco experiences periodic, extreme disturbances which devastate coral reefs surrounding the island. Scleractinian corals build the physical structure of the reef therefore ecosystem recovery relies on coral species recovery. Coral recruits can be of sexual or asexual origin, and the relative success of the two recruit types influences the speed and spread of recovery processes. Here we focus on the massive coral, Porites lobata, because it is the main reef-builder around Isla del Coco to describe the relative contribution of asexual and sexual recruits to population maintenance. P. lobata samples were collected using a spatially explicit random sampling design in three plots at Isla del Coco: Punta Ulloa (n=17), Bahía Weston (n=20) and Punta María (n=20) and samples were genotyped with 11 microsatellite markers. Additional sampling was conducted at three “coastal” sites near the Costa Rican mainland (Isla del Caño Biological Reserve): Caño1 (n=8), Caño2 (n=10), Caño5 (n=11) to compare the contributions of asexual and sexual recruits at Isla del Coco sites to coastal sites. Isla del Coco sites were characterized by small colony size (>60% of colonies <0.5m2) and high sexual reproduction. Sites were either mostly or entirely sexual,consisting of only unique genotypes (NG/N= 0.90-1.00; G O/GE=0.83-1.00; D=0.99-1.00). Although there were no significant differences in genetic diversity (number of alleles per locus, number of private alleles) or colony size between Isla del Coco and the coastal sites, the coastal sites exhibited a greater range of genotypic diversity from moderately asexual (NG/N=0.5; GO/GE=0.36; D=0.8) to purely sexual (NG/N=1.0; GO/GE=1.0; D=1.0). The mode of asexual reproduction in P. lobata is likely fragmentation of adult colonies rather than asexual larval production because ramets of P. lobata occurred close together and asexually produced larvae have not been reported in gonochoric broadcast spawners like P. lobata. Frequent sexual reproduction at Isla del Coco National Park might represent a resource for rapid recovery following extreme El Niño-Southern Oscillation (ENSO) disturbance events. In contrast, larger, asexuallyproduced fragments rather than smaller, sexually-produced larvae appear to have the advantage at some coastal sites. The high frequency of sexual reproduction at Isla del Coco indicates that not only are sexual partners available but also current conditions are favorable for the delivery of larvae and the rate of predation on small larval recruits must be moderate. Citation: Boulay, J.N. , J. Cortés, J. Nivia-Ruiz & I.B. Baums. 2012. High genotypic diversity of the reef-building coral Porites lobata (Scleractinia: Poritidae) in Isla del Coco National Park, Costa Rica. Rev. Biol. Trop. 60 (Suppl. 3): 279-292. Epub 2012 Dec 01.
Ley de Seguridad Nacional

ARTÍCULO 2.El Estado garantiza la supervivencia de la colectividad, la defensa del patrimonio nacional y la consecución y mantenimiento de los Objetivos Nacionales; y, tiene la función primordial de fortalecer la unidad nacional, asegurar la vigencia de los derechos fundamentales del hombre y promover el progreso económico, social y cultura¡ de sus habitantes, contrarrestando los factores adversos internos y externos, por medio de previsiones y acciones políticas económicas, sociales y militares.
Predicting Sagittal-Plane Swing Hip Kinematics in Response to Trips

State-of-the-art wearable lower-limb robot controllers typically use established baseline human kinematics during common mobility tasks. Unfortunately due to the variability in human response during perturbations, these lower-limb controllers are unable to effectively assist with perturbation recovery. Accurate and quick predictions of kine-matic responses to unexpected disturbances during motion can help assistive robotic devices safely aid with an individual's recovery. This paper presents three methods for predicting swing hip kinematics during trip recovery: a Gaussian process regression (GPR) model; a time-series neural network; and a pendulum model with linear feedback. Data were collected in an experiment where 16 subjects were tripped at random percentages of swing phase. The three prediction methods were applied to these data and evaluated for simulation accuracy and computation time. Both subject-specific and generalized models were investigated. Results indicate that the GPR model is the best choice for kinematic predictions due to its low simulation error in both subject-specific and generalized cases and lowest computation time.
Understanding MOOC Learners from Different Levels of Study: An Investigation of Hospitality and Tourism

Despite the increasingly severe manpower shortage in the hospitality industry and the emergence of the Covid-19 pandemic, different levels of learners of Massive Online Open Courses (MOOCs) in hospitality and tourism education have been largely neglected in literature. This study explores different levels of hospitality and tourism education learners' perceptions, motivations, obstacles, and perceived outcomes of MOOCs in Hong Kong. Data were collected from five focus group interviews. The findings show that MOOC learners could be categorised into 3 groups: i) Sub-degree and undergraduate learners who lack self-motivation, prefer flexible timing and with English as the main barrier to learn via MOOCs. ii) Postgraduate learners who have moderate motivation to learn via MOOCs, with the key determinants of knowledge acquisition, flexible learning, and electronic communication. They are capable and can self-regulate their learning paces. Lastly, iii) hospitality and tourism in-service learners have high motivation to learn via MOOCs, which provides a shortcut and flexibility for satisfying both employee and employer's requirements.
Active and Passive Back-Support Exoskeletons: a Comparison in Static and Dynamic Tasks

Studies on back-support exoskeletons focus mostly on the evaluation of single devices. Also, these studies suggest that passive exoskeletons might be preferred when performing static tasks, whereas active ones, could show their advantage in dynamic tasks. To verify this hypothesis and provide a comparison between different devices, in this study, we analyse the performance of the XoTrunk and the Laevo v2.56, an active back-support exoskeleton and a passive one, respectively. We analyse these devices highlighting their ability to reduce back muscle activation, perceived discomfort and usability. The study was carried out by simulating a dynamic and a static task. The results show that both exoskeletons reduce back-muscle activation levels, although the XoTrunk provides a reduction that was more than twice as large as the Laevo (e.g., 41% vs 16%, respectively). The results also show that, overall, in the dynamic condition, the XoTrunk has better scores than the Laevo. Conversely, in the static task, the participants in the study had a preference for the passive device, Laevo. The results presented in this work can help exoskeleton end-users to properly select the best device to fit their needs.
La comunicación comunicativa de los clubes de fútbol en españa con los medios de comunicación como público estratégico: análisis del modelo del f.C. Barcelona y del real madrid c.F. Y su percepción por los periodistas deportivos

La tesis ? La gestion comunicativa de los clubes de futbol en Espana con los medios de comunicacion como publicos estrategicos: analisis del modelo del FC Barcelona y del Real Madrid CF y su percepcion por los periodistas deportivos? consta de tres partes. Una primera aborda la importancia de la comunicacion como una herramienta estrategica que aporta valor anadido a la gestion de los clubes de futbol profesionales, entendidos estos como empresas. La segunda parte, el papel que desempenan los medios de comunicacion en general, y los periodistas deportivos, en particular, como publico objetivo de los clubes de futbol. Y la tercera parte, mas especifica, que centra el analisis en la gestion comunicativa del FC Barcelona y el Real Madrid CF, como clubes de referencia internacional, y la relacion que mantienen con los periodistas que cubren la actualidad informativa de estas entidades.
Caractérisation de la réponse T anti-vaccinale chez des patients atteints de mélanome

A number of therapeutic vaccines have been evaluated in patients with metastatic melanoma. Tumor regressions were observed in 20% of the vaccinated patients. Complete and long-term clinical responses have been occasionally observed. Some researchers have used autologous dendritic cells loaded with antigenic peptides to immunize patients, because dendritic cells are considered very effective in antigen presentation to T cells. A first objective of our work was to evaluate the anti-vaccine CTL responses in several patients vaccinated with dendritic cells loaded with antigens derived from the protein MAGE-3. The vaccine was able to induce a response in four of the five analyzed patients. This response was polyclonal in three of the four responding patients. The frequencies of antivaccine CTL ranged from 1/1 000 to 1/100 000 of blood CD8 T cells. While these responses were generally low, they seemed to be associated with tumor regressions. In one patient, we were able to extend our an. Document type : Thèse (Dissertation) Référence bibliographique Carrasco Bertrand, Javier. Caractérisation de la réponse T anti-vaccinale chez des patients atteints de mélanome. Prom. : van der Bruggen, Pierre Université Catholique de Louvain
A 3d scanner

The present invention relates to a 3D scanner (1) to the 3D modeling of a transparent object in real time by using the thermography technique for quality (quality) control in the industry, the slider 2, a heater 3, a thermal camera 5 and a control unit (6).
Delay in Iranian Scholarly Journals

Scholarly periodicals are considered as one of the main information resources that play a key role in the development of knowledge in a scholarly area. About 566 periodicals have the publication license from Commission of Scholarly Periodicals Evaluation of Ministry of Science, Research & Technology (MSRT) and of these, 68 are published in English. This paper aims to study the publication delay of these scholarly periodicals. For this purpose, the publication information concerned 26 periodicals was extracted through their official website and in sum, 835 published articles which were published in these periodicals in 2009 were studied. The results showed that peer review process and scholarly publication process in Iranian journals is long-standing and they should be improved. The results showed that the average of least-lasting peer review period has been 67 days and the average of most-lasting peer review period has been 518 days. In addition, the mean interval between article reception and acceptance notification is 1 Corresponding Author
Influence of Si-codoping on YAG:Ce scintillation characteristics

A set of undoped, Ce/sup 3+/-doped and Si/sup 4+/-codoped Y/sub 3/Al/sub 5/O/sub 12/ [yttrium aluminum garnet (YAG)] crystals were grown by the Czochralski method and submitted to /spl gamma/ irradiation in the dose range 1-236 Gy at RT, to investigate the possibility to reinforce crystal radiation hardness by Si/sup 4+/ doping. The absorption coefficients induced by the irradiation were calculated and analyzed. Crystals also underwent light yield (LY) and scintillation decay measurements using the /sup 241/Am and /sup 22/Na radioactive sources in 1 /spl mu/s time gate. The induced absorption at 550 nm (at the Ce/sup 3+/ luminescence peak) decreases with Ce concentration and further decrease is obtained in the Si/sup 4+/-codoped samples. LY values are independent on the Ce/sup 3+/ concentration within 0.12% - 0.3% and on the moderate Si/sup 4+/ codoping as well.
Revisar el principio de la educación como bien público

La educación ha sido considerada un derecho humano y un bien público en el campo global de la política pública al menos desde 1945. Desde entonces, esta conceptualización ha sido producida e impulsada por organizaciones internacionales, en particular por las agencias de la ONU y, entre éstas, por la UNESCO. Sin embargo, el panorama educativo ha cambiado considerablemente desde entonces y se encuentra ahora caracterizado por un involucramiento creciente de actores no-estatales, incluidas las organizaciones con fines de lucro. En este contexto, el presente artículo analiza la vigencia del concepto de bien público, anclado en teorías económicas, y cuestiona su potencial para contrarrestar los efectos de la privatización y la mercantilización de la educación. Después de una revisión minuciosa de los fundamentos teóricos del concepto de bien público y de sus limitaciones, el artículo argumenta que una lectura filosófica de los principios subyacentes al concepto parece una tarea apropiada en estos tiempos. Con base en ello, la autora sugiere la noción de la educación como un bien común para trascender visiones utilitarias y como vehículo para concebir la educación como una tarea colectiva desde una perspectiva humanista.
From Concentration to Isoperimetry: Semigroup Proofs

In a remarkable series of works, E. Milman recently showed how to reverse the usual hierarchy, and deduce from measure concentration inequali- ties, dimension free isoperimetric type inequalities in spaces with non-negative (Ricci) curvature. The results cover two basic instances, linear isoperimetry under arbitrarily slow concentration, and logarithmic strengthenings above the linear case under exponential concentration. The proofs are developed in a Rie- mannian (with density) context making use of isoperimetric minimizers and refined tools from geometric measure theory. In this note, we present simple semigroup arguments to cover the super-linear case, of potential usefulness in more general settings. A particular emphasis is put on functional inequalities for heat kernel measures.
Some correlations between the thermodynamic and transport properties of high Tc oxides in the normal state

We review some of the systematic patterns in the normal state properties of high temperature oxide superconductors which may help in the search for the pairing mechanism. A recent analysis of thermodynamic properties, namely the conduction electron entropy determined from high resolution specific heat data and the static magnetic susceptibility, both measured for a wide range of closely spaced compositions, yields much information about the effects of hole doping and zinc substitution on the low energy electronic excitations in these compounds. We attempt to correlate this information with the systematic changes observed in the electrical resistivity, Hall coefficient and most notably the thermoelectric power, for which a new scaling property is reported.
He II lambda 1640/lambda 4686 and Ly-alpha/H-beta ratios in the extraordinary Seyfert galaxy Markarian 359

The exceptionally narrow-lined Seyfert 1 galaxy Mrk 359 is ideally suited for determining reddening via the He II lambda 1640/lambda 4686 emission-line ratio. Here the validity of He II lines as a reddening indicator for quasars and Seyfert galaxies is reexamined and confirmed in the context of the most complete photoionization models available. In addition, lambda 1640 equivalent width measurements are shown to support previous contentions of substantial differences between observed and intrinsic quasar far-ultraviolet continua. Then IUE satellite and ground-based spectral data are presented, with the surprising result that both the lambda 1640/lambda 4686 and Ly-alpha/H-beta ratios do not differ greatly from case B recombination values in Mrk 359. This object is only slightly reddened, and it shows no evidence for extended, high-optical-depth H(+)/H(0) transition regions in the line-emitting gas. The very narrow lines and lack of deep transition regions and/or reddening may be related. In addition, Mrk 359 has low luminosity compared with most other Seyfert 1 galaxies, measured emission lines suggest an unusually high ionization parameter, and there is a hint of low nitrogen abundance. Further work is needed to examine possible relationships among all these peculiar properties.
Performance Financière des PME et pratiques des Mécanismes de Gouvernance : Cas de PME marocaines Industrielles

Aujourd'hui, le sujet de la gouvernance d'entreprise occupe une position primordiale parmi les preoccupations des decideurs des entreprises soucieuses d’ameliorer leur performance. On remarquable toutefois que les etudes portant sur la relation entre la gouvernance et la performance des entreprises sont souvent soulignees dans le contexte des grandes entreprises et tres peu dans le cas des petites et moyennes entreprises (PME). Dans ce cadre d'analyse, l'objectif du present travail est de mettre en evidence l'interaction liant la performance et les mecanismes de gouvernance des PME marocaines. L’examen des tests effectues sur un echantillon constituant de 39 PME marocaines a montre que la structure de propriete et le conseil d'administration jouent un role primordial dans l'amelioration de leur performance.
Image enhancement using background brightness preserving histogram equalisation

Histogram equalisation (HE) is widely used to enhance the image contrast but it tends to over-enhance the image background brightness. Improvement schemes have been introduced to reduce this defect of the conventional HE, but the over-enhancement of the background brightness is still obvious. A novel approach of nonlinear HE is presented, which is able to enhance the image contrast while preserving the background brightness for images with well-defined background brightness.
Viscous simulation of shock-reflection hysteresis in overexpanded planar nozzles

A computational fluid dynamics simulation of the flow in an overexpanded planar nozzle shows the existence of Mach-reflection hysteresis inside the nozzle. Previous simulations have dealt only with the flow outside the nozzle and thus concluded that the hysteresis phenomenon takes place outside the nozzle even when viscous effects are introduced. When including the geometry of the nozzle in the simulation it becomes evident that flow separation will occur before the transition from regular to Mach reflection for all relevant Mach numbers. The simulation reveals complex changes in the flow structure as the pressure ratio between the ambient and the jet is increased and decreased. The pressure along the nozzle wall downstream of the separation point is found to be less than the ambient pressure, and a modification of the Schilling curve fit is suggested for cases of extensive flow separation.
Strong nonlinear optical response of graphene in the terahertz regime

We demonstrate that within the model of massless Dirac fermions, graphene has a strong nonlinear optical response in the terahertz regime. It is found that the nonlinear contribution significantly alters both the single frequency and frequency tripled optical response at experimentally relevant field strengths. The optical activity of single layer graphene is significantly enhanced by nonlinear effects, and the frequency tripled response opens the gateway to photonic and optoelectronic device applications.
The galaxy luminosity function and environmental dependencies

The observational data base for the Nearby Galaxies Atlas (Tully and Fisher, 1987) and Nearby Galaxies Catalog (Tully, 1988) is analyzed statistically, with a focus on three problems related to the galactic luminosity function (GLF). Sample data are presented in tables and graphs; the GLF is formulated as M(asterisk) = -20.18 + 1.25(1 + alpha) + 5log h(75); and alpha = -1.0 is recommended. An expression for the degree of incompleteness in the catalog is then derived as a function of galaxy distance, and the correlation between galactic morphology and the local density function is explored. It is shown that gas-poor, early-type, and gas-rich galaxies tend to appear in regions of high, intermediate, and low density, respectively. Within the gas-rich subset, however, morphology and luminosity are found to be poorly correlated with density. 20 references.