Miracle-dz/UniFAR-FTUs huggingface dataset:
Intérêt du blocage des récepteurs de l'angiotensine II dans le traitement de l'hypertension artérielle : analyse des résultats de l'étude VALUE

L'etude VALUE (Valsartan Antihypertensive Long-term Use Evaluation) a ete concue pour comparer l'efficacite d'un antagoniste des recepteurs AT1 de l'angiotensine II, le valsartan, a celle d'un antagoniste calcique, l'amlodipine, sur la prevention des complications cardiovasculaires chez des hypertendus a risque eleve. Il s'agissait d'un essai prospectif, multicentrique, randomise, en double aveugle, mene sur 15245 patients souffrant d'hypertension arterielle essentielle a haut risque de complications cardiovasculaires. Les traitements (instaures a la posologie journaliere de 80 mg pour le valsartan et de 5 mg pour l'amiodipine) etaient administres selon un schema a cinq paliers (incluant des augmentations de doses et l'adjonction d'autres antihypertenseurs), concu pour atteindre une pression arterielle systolique/diastolique inferieure a 140/90 mmHg. La duree moyenne de suivi a ete de 4,2 ans. Les deux traitements ont entraine une baisse de la pression arterielle, significativement plus importante dans le groupe amlodipine (difference intergroupe: 4,0/2,1 mmHg apres un mois ; 2,1/1,6 mmHg apres six mois). La probabilite de survenue d'un premier evenement cardiovasculaire n'a pas ete significativement differente entre les deux groupes (10,6 % versus 10,4 % respectivement dans les groupes valsartan et amlodipine ; p = 0,49). L'amlodipine a entraine une reduction de la survenue d'infarctus du myocarde (4,8 % versus 4,1 %; p = 0,02) et d'accident vasculaire cerebral (4,2 % versus 3,7 % ; p = 0,08), et le valsartan une reduction de la survenue de diabete (13,1 % versus 16,4 % ; p < 0,0001). Cet essai fait ressortir l'importance du controle tensionnel dans la prevention des complications cardiovasculaires des patients hypertendus a haut risque et confirme l'implication du systeme renine-angiotensine dans la physiopathologie du diabete.
Nonlinear propagating exciton-polaritons in microcavity wires and waveguides

Exciton-polaritons are the quasiparticles resulting from the strong coupling between photons and excitons. The strong nonlinearity due to their particle-particle interaction and the capability of accessing their spin from outside, are of great importance for fundamental physics research and possible future applications. In this thesis we study the nonlinear propagation of polaritons in waveguides and microcavity wires. Both systems have inherent advantages that make them promising building blocks for future polariton circuits. Whilst waveguides are easier to fabricate and usually show longer propagation distances, microwires have a characteristic energy-momentum dispersion with finite energies at k=0 which, as I will show in this thesis, is required for the formation of Cherenkov radiation and bright conservative solitons. The study of polariton propagation in both systems is necessary as they could be used for different technological applications, such as amplifiers and optical processing and transmission. Firstly, we experimentally demonstrate amplification and nonlinear modulation of pico-Joule pulses in a polariton waveguide. We achieved a maximum gain of 4.3 dB for a pump region 0.1 mm long. We explain the interplay of nonlinearity and gain as a result of stimulated scattering from a continuous-wave reservoir of excitons and polaritons generated by the pump, that amplifies the polariton field. In the second part of the thesis, we study propagation of conservative bright solitons in microwires and its accompanying effects. We observed Cherenkov radiation travelling in the opposite direction to the solitons emitting it. We show that the formation and propagation direction of the Cherenkov radiation is determined by the microwire polariton dispersion. Finally, we study the polarization of bright solitons propagating in microwires. We recorded polarization precession at low excitation powers and domain formation at higher powers. We explain the observed polarization domains as a result of spin-dependent polariton-polariton interactions and an imbalance of polariton spin populations.
Da detecção de sinais de risco para autismo à intervenção precoce

Autism Spectrum Disorder (ASD) is characterized by persistent deficits in communication and social interaction, besides repetitive patterns of behavior and restricted interests. The purpose of this program was to verify the effect of the application of a parenting teaching program / caregivers about their child's performance. An 18-month-old girl with ASD and her caregiver participated in the program. It is almost experimental, intra-subjects, type AB (baseline, treatment and follow-up). An individualized program to teach the caregiver ludic procedures was conducted to promote social interaction and an increase in the interactive shifts between both participants. The performances were registered in 40-min weekly sessions for a year. Data from the caregiver's responses were followed by Tau-U. This statistic, not parametric, revealed that not all the caregiver´s responses, in the intervention phase, showed strong effects of the treatment, while others attested its robustness. With 95% likelihood of success, the intervention procedures significantly affected the following caregiver´s responses: "using children's songs" and "making a funny or complimentary commentary to have the child return to play. " There was a great increase of Izabel´s initiatives and the caregiver´s responses as well as both several types of responses (vocal/verbal, gestural and mixed). Thus, the caregiver´s training program strongly influenced the shifts frequency and the child´s types of responses; and that the caregiver intervention, guided by a professional, can be effective and adequate to the Brazilian socioeconomic context.
Narrowing the empathy gap between doctors and patients using emotion forecasting

We investigated the differences between medical students’ affective forecasting for self and their forecasting of patients’ affective responses. To do this, we developed an affective forecasting situation questionnaire and tested its validity with a sample of 272 Chinese medical students and 66 patients. Results showed that there was a significant correlation between medical students’ affective forecasting for self and their forecasting of patients’ emotions. Medical students who were calmer (vs. less calm) during affective forecasting for themselves were more accurate in forecasting the patient’s emotions. We suggest that emotional intelligence training should be highlighted in Chinese medical education to improve students’ ability to forecast their own and others’ emotions.
The History of Modern Ophthalmology in Nigeria: A Synopsis of Institutions, Events and Personalities

Ophthalmology in Nigeria has developed over the decades with contributions from several personalities. Many events and institutions have served to shape the emergence of good care, from the establishment of ECWA Eye hospital in 1943 as one of the premiere indigenous dedicated Eye Hospitals, to the establishment of the National Eye Centre as well as the University College Hospital Ophthalmology department, the specialty of Ophthalmology has grown to enviable heights. The formation of the Ophthalmological Society of Nigeria in 1969 and the establishment of the National Postgraduate College and The West African College of Surgeons equally stand out as landmark events in History. The Nigerian National Survey of Blindness and Visual Impairment (2005 to 2007) was the biggest ever survey in Africa, no national level estimates existed in Nigeria before the survey. This gigantic task took more than three years to complete including 30 months of rigorous fieldwork and was only possible because of the special efforts of key individuals. The MTN EYE FOUNDATION Eyeris Program (2013 2017) also stands out as a landmark surgical intervention scheme involving 12 Mini-review Article Oderinlo et al.; OR, 11(4): 1-8, 2019; Article no.OR. 54179 2 states in all geopolitical zones in Nigeria. A total of 18,438 free cataract surgeries were performed, 23,528 eyeglasses and 23,226 ocular medications for ocular allergies, glaucoma and ocular infections were also given free to beneficiaries.
Potentiation of Warfarin Anticoagulant Activity by Miconazole Oral Gel

Warfarinの 抗凝 固作用 は,他 の薬物 との相互作 用 に よって変動 す るこ とが多 い. 通 常用 い られ るwarfarinは2つ の光学異性体S-体 お よびR-体 の ラセ ミ 体で あ るが,抗 凝 固作 用 を示 すの は主 としてS-体 で ある. S-体 とR-体 の代謝経路 はそれ ぞれ異 なってい るが,S-体 は主 として7位 が水酸化 を受 けて不活性体 に変換 され,こ の代 謝 に は肝CYP(チ トク ロムP450)2C9の 関与 してい ることが知 られている1). 一方, miconazoleな どのimidazole系 あ るい はtriazole系 抗真菌薬 は,CYP2C9に 対 し阻害作 用を示す こ とが知 られ てお り2,3),warfarin投 与 中患者 へ の併用 は抗凝 固作用が増強 され るため注意 を要す ることが報告 され ている4~7). しか し,経 口miconazoleは 消化管粘膜 か らの全身吸収 率が低 く,ゲ ル製剤 か らの吸収 はほ とん ど無視 し得 ると考 え られてお り,比 較的安全性 の高 い 薬 剤 とされ てい る8). 一 方,こ れ まで に経 口miconazoleゲ ル製 剤 に よるwarfarinの 作 用増 強例 の報告 が国内外 で散見 され るが9~13),我々の施設 において も 同様 な相互作 用発現例 を経験 したので報告す る.
UNDERSTANDING ONLINE FOOD ORDERING: HOW THE PROCESS RESULTS IN SATISFACTION OF THE CUSTOMERS

The purpose of this study is to understand which factors affect customer satisfaction as well as future behavioral intention in online food ordering. A conceptual model was developed to assess the effect of factors on customer satisfaction. The dimensions of online service quality are identified through existing literature. The study employed a quantitative research design collecting data via convenience sampling. Data were analyzed by regression model to test the proposed hypotheses. The results show that website quality, delivery, and food quality explain the satisfaction of customers for online food ordering, which, in turn positively affects future behavioral intentions.
The Effect of Implant Screw Coating with Nano-Hydroxyapatite and Magnesium Chloride Mixture on Osseointegration: Biomechanical and Histological Study

The goal of modern implantology is fine and fast osseointegration which is a major factor influencing the success of dental implantation, and its largely depend on the implant surface. High-quality osseointegration stand for an accelerated healing process, high stability, and durability of the dental implant. Aim: To evaluate the effect of composite material coating which includes ceramic nano hydroxyapatite and magnesium chloride on the bond strength at bone implant interface and tissue reaction. Methods: In in vitro study, a plate of Cp-Ti was coated with hydroxyapatite and MgCl2 by electrophoretic deposition coating technique. Coating procedure was performed using different proportion of hydroxyapatite and MgCl2 and different coating time at fixed voltage. Then analysis of coated surface was performed. The tibia of white male New Zealand rabbits were chosen as implantation sites of 40 screws for in vivo study. Torque removal test was performed to measure bond strength between implant and bone after 2 and 4 weeks healing periods. Results: The results of Energy-dispersive X-ray spectroscopy shows that 1.9% of Mg and 32.4% Ca contain on Ti substrate. Optical microscope examination showed that 2 minutes is the suitable time used for coating screws at 30 V. Analysis of surface roughness in nanoscale was 86.89 nm and grain size 128 nm while scanning electron microscope showed numerous agglomerations of small spherical particles between 5 nm and 100 nm of hydroxyapatite. The torque mean value at bone-implant interface in coated implants was significantly higher than the uncoated implants at 2nd and 4th week. In histological analysis, there was an interdigitating of well-developed bone close opposing threads of coated implants after 2 and 4 weeks implantation. Coating Cp-Ti screws with mixture of hydroxyapatite and MgCl2 was efficient in increasing bone bonding strength to dental implant at bone implant interface than uncoated implant, which was demonstrated by higher torque removal force and increase in bone formation around screw with time.
Influence of Grating Parameters on the Field Enhancement of an Optical Antenna under Laser Irradiation

Abstract: In this study, a new approach for simulation of electric field enhancement of plane wave laser around optical antenna was used to convert free-propagating optical radiation to localized energy. A tapered gold tip design as a novel geometry of optical antenna is introduced and numerically analyzed based on particle swarm optimization (PSO) by solving the Maxwell equations with FDTD simulation Lumerical Software. Five simulation stages of grating parameters to reach the maximum output intensity at the gold tip hot spot were performed with 90° laser incident angle. The optimal values of the grating period “a”, distance of the last circular grating from tip apex “b”, depth of etched grating “T” and duty cycle of grating “D.C” were obtained a=262.2 nm, b=759.5 nm, T=30.1 nm, and D.C.=0.31 respectively. By using these optimal parameters for the gold tapered tip with a cone angle of 30° at room temperature, the maximum output intensity (|Emax|) at the hot spot was obtained 52.4751.
Foreign exchange prediction based on indices and commodities price using convolutional neural network

The level of accuracy in predicting is the key in conducting forex trading activities in gaining profits. Some predictions are made only by using historical currency data to be predicted, this makes predictions less accurate because they do not consider external influences. This study examines external factors that can influence the results of predictions, by looking for the relationship between the value of indices such as NTFSE and S & P 500 and the value of commodities such as gold and silver to the prediction process of EUR / USD. Prediction carried out using a deep learning algorithm with the Convolutional Neural Network method uses 2 1-dimensional convolution layers with ReL activation. The data used is the value of Open, High, Low and Close prices on forex, indices and commodities which are combined into one with the close forex value target for the next 5 days. Testing of EUR / USD test data only gets MSE results of 0.00081894. While the results of testing of the combined test data between EUR / USD, indices and commodities producing MSE vary between 0.00068717 to 0.0109606 where the best combination is a combination of FTSE 100 and Natural Gas values. So it can be concluded that other factors included in predicting have an influence on the results obtained.
New Computational Artificial Intelligence Models for Generating Synthetic Formation Bulk Density Logs While Drilling

Synthetic well log generation using artificial intelligence tools is a robust solution for situations in which logging data are not available or are partially lost. Formation bulk density (RHOB) logging data greatly assist in identifying downhole formations. These data are measured in the field while drilling by using a density log tool in the form of either a logging while drilling (LWD) technique or (more often) by wireline logging after the formations are drilled. This is due to operational limitations during the drilling process. Therefore, the objective of this study was to develop a predictive tool for estimating RHOB while drilling using an adaptive network-based fuzzy interference system (ANFIS), functional network (FN), and support vector machine (SVM). The proposed model uses the mechanical drilling constraints as feeding input parameters, and the conventional RHOB log data as an output parameter. These mechanical drilling parameters are usually measured while drilling, and their responses vary with different formations. A dataset of 2400 actual datapoints, obtained from a horizontal well in the Middle East, were used to build the proposed models. The obtained dataset was divided into a 70/30 ratio for model training and testing, respectively. The optimized ANFIS-based model outperformed the FN- and SVM-based models with a correlation coefficient (R) of 0.93, and average absolute percentage error (AAPE) of 0.81% between the predicted and measured RHOB values. These results demonstrate the reliability of the developed ANFIS model for predicting RHOB while drilling, based on the mechanical drilling parameters. Subsequently, the ANFIS-based model was validated using unseen data from another well within the same field. The validation process yielded an AAPE of 0.97% between the predicted and actual RHOB values, which confirmed the robustness of the developed model as an effective predictive tool for RHOB.
Recent Advances in the Recovery Techniques of Plant-Based Proteins from Agro-Industrial By-Products

ABSTRACT High demands for plant-based proteins have led food technologists to search for new and alternative sources. This review presents and discusses recent developments in the recovery of proteins from plant origin by-products. The innovative protein extraction techniques have advantages over conventional methods as they are cheap, eco-friendly, high efficiency as well as produce versatile final products. Different recovery techniques provide variable yields and features whereas the resulting protein isolates/hydrolysates are dependent upon the type of material and process conditions. Future studies are required to exploit potential plant-origin agro-industrial by-products, and to investigate the efficiency of recovery.
Dermal denticle assemblages in coral reef sediments correlate with conventional shark surveys

It is challenging to assess long‐term trends in mobile, long‐lived and relatively rare species such as sharks. Despite ongoing declines in many coastal shark populations, conventional surveys might be too fleeting and too recent to describe population trends over decades to millennia. Placing recent shark declines into historical context should improve management efforts as well as our understanding of past ecosystem dynamics. A new palaeoecological approach for surveying shark abundance on coral reefs is to quantify dermal denticle assemblages preserved in sediments. This approach assumes that denticle accumulation rates correlate with shark abundances. Here, we test this assumption by comparing the denticle record in surface sediments to three conventional shark survey methods at Palmyra Atoll, Line Islands, central Pacific Ocean, where shark density is high and spatially heterogeneous. We generally found a significant positive correlation between denticle accumulation rates and shark abundances derived from underwater visual census, baited remote underwater video and hook and line surveys. Denticle accumulation rates reflected shark abundances, suggesting that denticle assemblages can preserve a signal of time‐averaged shark abundance in low‐energy coral reef environments. We offer suggestions for applying this tool to measure shark abundance over long time‐scales in other contexts.
Temporal Signatures of Criticality in Human Cortical Excitability as Probed by Early Somatosensory Responses

Brain responses vary considerably from moment to moment, even to identical sensory stimuli. This has been attributed to changes in instantaneous neuronal states determining the system's excitability. Yet the spatiotemporal organization of these dynamics remains poorly understood. Here we test whether variability in stimulus-evoked activity can be interpreted within the framework of criticality, which postulates dynamics of neural systems to be tuned toward the phase transition between stability and instability as is reflected in scale-free fluctuations in spontaneous neural activity. Using a novel noninvasive approach in 33 male human participants, we tracked instantaneous cortical excitability by inferring the magnitude of excitatory postsynaptic currents from the N20 component of the somatosensory evoked potential. Fluctuations of cortical excitability demonstrated long-range temporal dependencies decaying according to a power law across trials, a hallmark of systems at critical states. As these dynamics covaried with changes in prestimulus oscillatory activity in the alpha band (8-13 Hz), we establish a mechanistic link between ongoing and evoked activity through cortical excitability and argue that the co-emergence of common temporal power laws may indeed originate from neural networks poised close to a critical state. In contrast, no signatures of criticality were found in subcortical or peripheral nerve activity. Thus, criticality may represent a parsimonious organizing principle of variability in stimulus-related brain processes on a cortical level, possibly reflecting a delicate equilibrium between robustness and flexibility of neural responses to external stimuli. SIGNIFICANCE STATEMENT Variability of neural responses in primary sensory areas is puzzling, as it is detrimental to the exact mapping between stimulus features and neural activity. However, such variability can be beneficial for information processing in neural networks if it is of a specific nature, namely, if dynamics are poised at a so-called critical state characterized by a scale-free spatiotemporal structure. Here, we demonstrate the existence of a link between signatures of criticality in ongoing and evoked activity through cortical excitability, which fills the long-standing gap between two major directions of research on neural variability: the impact of instantaneous brain states on stimulus processing on the one hand and the scale-free organization of spatiotemporal network dynamics of spontaneous activity on the other.
of detecting similar elements

In this research, we try to reduce the execution time of NCDSearch, an existing source code search tool. The original method takes as input a code fragment as a query and searches its similar fragments in target ﬁles line by line. Our new method ﬁrstly tests source code inclusion relationship so that the tool can search only ﬁles which likely include the query code fragment. To test the relationship eﬃciently, we introduce Bloom ﬁlter with n-gram model. In an evaluation experiment, we replicated the experiment to evaluate the original method with the new method. As a result, the usefulness of this method was conﬁrmed from the viewpoint of the accuracy and the processing time .
Impact of Mental Illness on Creativity in Visual Art

Mental illness, creativity, and visual art are often influenced by each other. Medical science proved that highly creative people are suffering from a different kind of mental illness or disorder. Mental illness and creativity is a comprehensive process and influenced by internal and external factor. The purpose of this research was to analyze the influences of the mental illness on creativity in visual art such as schizophrenia disorder, mood disorder, alcoholism, bipolar disorder, hereditary psychosis, manic depression, etc. The study investigated the mental illnesses impact on the perception of the artist and their artwork. This paper argues that what and how mental disorder are positively associated with creativity and evolutionary perspective in between madness behavior and creativity through visual art. The study aim was to bring up the latest literature as well as the epidemiologic and hypothetical argument of this subject matter.