Miracle-dz/UniFAR-FTUs huggingface dataset:
2-Hydroxy-1,4-naphthoquinone

The title compound (C10H6O3) crystallizes with two molecules per asymmetric unit. In both molecules, the naphthoquinone ring system is approximately planar with the hydroxyl H atoms located in the plane. The crystal packing shows the molecules assembled in infinite linear chains by means of O-H⋯O hydrogen bonds between alternating independent molecules.
HEALTHY INDOOR AIR ENVIRONMENT FOR PREVENTING NOSOCOMIAL TRANSMISSION OF MYCOBACTERIUM TUBERCULOSIS IN SUSTAINABLE HOSPITAL BUILDING DESIGN

The Sick Building Syndrome is often related to poor indoor air quality. Healthy indoor air environment is needed for a healthy hospital building. Appropriate design elements need to be implemented to accommodate the mass usage of a hospital’s various facilities. Tuberculosis (TB) is an infectious disease most commonly caused by Mycobacterium tuberculosis (MTB) which can spread via inhalation of infected aerosols. Therefore, Health Care Workers (HCWs) in a hospital are most vulnerable to tuberculosis infection. This paper explicates the sources and factors of TB transmission in the indoor environment of Hospital Sultanah Aminah Johor Bahru, Johor, Malaysia (HSAJB). The study considered the relationship between the physical layout of the TB ward and its indoor air environment quality. This study utilized opinion from HCWs who are directly exposed to this kind of environment. The data was obtained from face-to-face questionnaire surveys. The questionnaire used the Likert scale with five ordinal measures of agreement. From the study, it was found that the source of TB transmission is from positive MTB carriers or active TB patients. Ten Indoor Air Environment Sustainability (IAES) factors related to the transmission and spread of TB which are relatively connected to space area design of TB ward.
Flow cytometric analysis of CD4 and CD8 T cell subsets in some Iraqi patients with Diabetes Mellitus Type2

Cell-mediated immunity was estimated in diabetic patients by evaluation the percentage of CD4 and CD8 by flow cytometry in healthy controls and type 2 diabetic patients . Of the 50 patients with type 2 diabetes mellitus 26 were males and 24 were females, as well as the healthy control were made up of 12 males and 18 females. The diabetes patients attend the outpatient Clinic in the National Diabetes Center, Al-Mustansiriya University. Besides that, the results of this study recorded that the mean of age among patients with type 2 diabetes mellitus was 49.48 ± 1.03 y whereas mean of age among healthy controls was 45.40±1.31 y with highly significant difference was noticed between them. In addition, the result of this study indicated that duration of disease among type1 diabetic patients was 9.7±2.1 y . For CD4 lymphocytes, there was a highly significant decrease (P<0.001) in the percentage means of the CD4 cells in type2 diabetic patients, as compared with healthy controls. For CD8 lymphocytes, there was a highly significant decrease (P<0.001) in the percentage of these lymphocyte in the peripheral blood of the type 2 diabetic patients, as compared with healthy controls. In conclusion, this study proved that impaired cell mediated immunity is prevalent in type 2diabetic patients, thus the change level of cytotoxic T lymphocytes (CD8) and helper T- lymphocytes (CD4) might be responsible for depressed immune response in patients with type 2 diabetes.
Effects of oral isotretinoin on serum lipids and gamma glutamyl transpeptidase activity in acne vulgaris patients

The aim of the present study was the evaluation of serum level of lipids and gamma glutamyl transpeptidase (GGT) activities in patients with acne vulgaris undergoing isotretinoin treatment. Forty-four patients, with severe acne or moderate acne (age mean 23.6±6.0 year) who were resistant to conventional treatment were supplemented with 0.5 mg/kg/day of oral isotretinoin for 120 days. This study revealed a significant increase in serum level of cholesterol, triglyceride and GGT activity. The findings of this work showed a number of negative effects of isotretinoin on disturbances in lipid profile and antioxidant status, in acne patients. Therefore, to control abnormalities in lipid profiles and oxidative stress, we recommend further studies to use antioxidant such as vitamin E supplementation in patients using isotertinoin. Key words: Acne vulgaris, isotertinoin, serum lipid, gamma glutamyl transpeptidase (GGT).
HEMATOPOIETIC GROWTH ASPECTS: MANIFESTATION OF VULNERABILITIES AND PROSPERITY IN HUMAN CANCER

A regular reaction of cancer medicine is bone marrow concealment. The resulting myelosuppression and irondeficiency can cause huge morbidity and mortality for patients. Mediators, for example granulocyte colonystimulating factors (GCSF) and erythropoietin stimulating agents (ESAs) may be supportive to enhance thissorrow of blood counts; however these executors have dangers which likewise need to be deliberately weighed . KEYWORDS: Granulocyte colony stimulating factors (GCSF), Pegfilgastrim, and Erythropoietinstimulating agents (ESAs)
PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO GRANDE DO SUL PROGRAMA DE PÓS-GRADUAÇÃO EM MEDICINA E CIÊNCIAS DA SAÚDE ÁREA DE CONCENTRAÇÃO: NEFROLOGIA

INTRODUCTION: preeclampsia still remains as the main cause of fetal and maternal morbidity and mortality, with unknown etiology. Vasoconstriction plays a major role in its pathophysiology. It is known that this syndrome only occurs in the presence of placenta or trophoblastic tissue, and the release of placental factors is associated to the clinical manifestations of preeclampsia. The aim of the present study is to evaluate the serum levels of estradiol, progesterone and nitric oxide in normal nulliparous pregnant women and individuals with preeclampsia syndrome. PATIENTS AND METHODS: Case-control study in pregnant women attending the antenatal care or the obstetrics service of Hospital São Lucas from PUCRS. All women were in the third pregnancy trimester, and gave informed consent. Exclusion criteria were in vitro fertilization, aloimunization, known maternal disease, multiple pregnancies, known cromossomic abnormalities, fetal malformation, consent withdrawal or lack of laboratory data. Ten mL of blood were drawn, the serum was stored at –80C and hormones were measured by radioimmunoasssay. Nitric oxide was evaluated by chemoluminescence. Descriptive analysis, Student`s t test, Pearson correlation coefficient were employed for statistical analysis, with α ≤ 0,05 being significant. RESULTS: The study sample consisted of 60 pregnant women – 30 with peeclampsia syndrome and 30 women whith normal pregnancies. No significant difference between the two groups was detected for estradiol, progesterone or nitric oxide (estradiol 30.4 + 19.0 Fabíola Zoppas Fridman XV ng/mL; progesterone 574.1 + 227.0 ng/mL in preeclampsia syndrome and 31.6 + 16.6 ng/mL and 640.9 +358.1 ng/mL in normal pregnancy respectively). Nitric oxide was not different between the two groups (13818.0 +7603.9 μM in preeclampsia syndrome and 13371.8 + 7801.9 μM in normal pregnancy). CONCLUSIONS: serum levels estradiol, progesterone and nitric oxide were not significantly different between nulliparous women in the third pregnancy trimester with or without preeclampsia syndrome and serum levels of such hormones are not markers of the pathophysology of preeclampsia.
Studies on chronic administration of chloroquine on gastrocnemius muscle and spleen of Swiss albino mice

The aim of the present study was to investigate the influence of chloroquine on some vital tissues of mice (gastrocnemius muscle and spleen). Healthy adult male Swiss albino mice weighing between 30 and 40 g were used for the study. Treated group was exposed to 200 mg/kg body weight/day of chloroquine phosphate given orally for 45 days. Control animals were given distilled water for the same period. Microscopic examination of muscle and spleen revealed concomitant changes in histology. Thus, the use of chloroquine for longer periods requires strict monitoring as chronic usage may lead to many detrimental effects in the host. Key words: Malaria, Chloroquine, toxicity, gastrocnemius muscle, spleen.
Up-regulation of HO-1 attenuates left ventricular remodeling post myocardial infarction in rats

Background/Objective: Reperfusion injury is a serious consequence of blood flow reestablishment after myocardial infarction (MI) mediated by reactive oxygen species and neutrophilic cellular damage. Following MI, the left ventricle (LV) undergoes remodeling characterized by progressive wall thinning and cavity dilatation. HemeOxygenase-1 (HO-1) dependent decrease in oxidative stress may attenuate injury in part by inhibiting transcription factor NFκB-mediated inflammation. Hypothesis: I hypothesized that upregulation of HO-1 by hemin administration confers acute and chronic cardioprotection against I/R injury in rats and attenuates LV remodeling post-MI. I proposed the HO-1-dependent decrease in oxidative stress attenuates post-ischemic myocardial injury in part by inhibiting NFκB-mediated inflammation. Methods: Six week old male Wistar rats were randomly assigned to sham, vehicle, or hemin-treated groups. Vehicle and hemin were administered intraperitoneally once daily for 3 consecutive days prior to left anterior descending (LAD) coronary artery occlusion. Administration resumed 48 hours post-operatively and continued once every 3 days. Infarct size was determined by H&E histological analysis and fibrosis was quantified by Masson’s Trichrome staining. Transthoracic echocardiography was used to assess LV parameters and wall motion. Results: Hemin increased HO-1 expression, decreased infarct size and fibrosis, and attenuated LV remodeling in the short-term (4 days postinfarction). The decrease in infarct size and area of fibrosis in the hemin group was accompanied by a decrease in NFκB activity. No significant difference in infarct size and area of fibrosis between hemin and vehicle-treated groups was observed at 3 months.
Benchmarking the Quality of Medical Care of Childhood-Onset SLE

Objective: Quality indicators (QI) are minimum standards of medical care in support of optimal disease outcomes. In childhood-onset systemic lupus erythematous (cSLE), 26 QI, which are categorized into nine domains, have recently been developed based on international consensus and scientific evidence. The objective of this study is to assess the current quality of medical care received by patients with cSLE. Methods: Cross-sectional data pertaining to the QI were acquired via chart review and analyzed collectively in 308 cSLE patients followed at four tertiary pediatric rheumatology centers in the United States. Results: Adherence to the QI across the centers varied widely, ranging from 28 to 100%. The QI with the highest adherence (99%) fell under the Medication Management and Lupus Nephritis & Hypertension Management. Most of the QI were satisfactorily met while nine QI were not. These nine QI were classified under the following domains: Medication Management, General Prevention, Lupus Nephritis and Hypertension Management, Bone Health, Ophthalmological Surveillance and Education on Cardiovascular Risk Factors. Adherence to the QI was almost similar across the two larger centers, with some differences against the other smaller centers, supporting the suitability and appropriateness of the current cSLE QI for use. Conclusion: Based on this benchmarking effort, the medical care of patients with cSLE at tertiary centers adheres to most of QI standards, but certain areas of care required remediation.
Neonatal calf diarrhoea: a case study

This article describes the investigation of a neonatal calf diarrhoea outbreak in a dedicated tuberculosis isolation unit. Like many calf rearers purchasing young calves, this farmer did not have control over the first 7 days of their lives. Focus therefore was on treatment of sick animals, reducing the risk of spread of pathogens and diagnostic testing to aid management. Longer term an all‐in all‐out programme followed by disinfection, and a review of purchasing policy to help selection of source farms was established.
Antimicrobial activities of methanol extract of Sir ih Merah (Piper crocatum L. ) lleaf

Hand washing is a simple thing but that is very imp ortant as one as a trick prevention for infection d isease. The study is implemented by using research experimental . As an independent variable is washing hands with some materials and as a dependent variable is counting t he colony. The materials that used isPiper crocatum extract, hand soap with no antiseptic, and hand soap with an tiseptic. Sample quantity for each material is 14 p eoples. The percentage decrease of total colony numbers after w ashing hands with piper crocatum extractis71.21%, withnoantisepticsoap33.68%, and43.69% with antisept ic soap, respectively. Microbe quantity counted by before and after hand washing and analyzed by t-test paired. H and washing used by three materials indicated stati stical of microbe numeral (p<0,005). Water, tissue/napkin dry er, and the behavior of hand washing can be influen ce the total microbe after hand washing. Decline significa nt mean compare of before hand washing is with use antiseptic handsoap and Piper crocatum methanolic extract.
Rôle des acides aminés dans la limitation de l’adiposité sous régime hyperprotéique.

Plusieurs etudes ont montre que certaines kinases situees dans le foie, « mammalian target of rapamycin » (mTOR), « adenosine monophosphate-activated protein kinase » (AMPK) et « general control non-depressible kinase 2 » (GCN2) repondent a la disponibilite en acides amines.L’objectif de nos etudes a ete de preciser le role de deux de ces voies, l’AMPK et GCN2, dans les adaptations du metabolisme energetique et de la synthese proteique en reponse aux variations en proteines du regime. Pour cela, des souris de type sauvage et des souris KO n’exprimant plus la voie AMPK ou GCN2 dans le foie ont ete nourries pendant trois semaines avec un regime faible, normal ou fort en proteines. Les analyses ont montre que les souris KO-AMPK foie specifique et nourries sous regime normoproteique adaptent leur metabolisme hepatique notamment en secretant le facteur fibroblastique FGF21 ce qui leur permet de compenser l’absence d’AMPK et de presenter des profils d’oxydation normaux.Au contraire, les souris KO-AMPK foie specifique nourries avec des regimes faibles ou forts en proteines presentent des alterations des profils d’oxydation des lipides et des glucides liees a une absence de modification du metabolisme hepatique.La deletion de GCN2 dans le foie, quant a elle, n’a d’effet que sous regime faible en proteines : les souris KO-GCN2 foie specifique presentent une plus faible oxydation lipidique et une plus forte oxydation glucidique que les souris sauvages en periode postprandiale du a l’absence d’induction de la secretion de FGF21.Concernant le metabolisme des proteines, les kinases GCN2 et AMPK ne semblent pas impliquees dans l’intensite du flux de synthese proteique dans le foie et en peripherie dans le muscle en periode postprandiale.En conclusion, ces travaux montrent que les deletions de l’AMPK et de GCN2 hepatiques affectent le metabolisme energetique mais pas le metabolisme proteique et que les consequences dependent de la composition du regime.
Studies on hydrazidehydrazones derivatives as acetylcholinesterase inhibitors

1Al-Azhar University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Gaza, Palestine. 2Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Haydarpasa, Istanbul Turkey 3Gaziantep University, Faculty of Arts and Sciences, Pharmacy, Department of Chemistry, Gaziantep Turkey 4Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Eskisehir Turkey
Children born very prematurely at school age: lung function and outcome after antenatal and neonatal dexamethasone treatment

1 LIST OF ORIGINAL PUBLICATIONS 3 ABBREVIATIONS 4 CONTENTS 5 INTRODUCTION 8 REVIEW OF LITERATURE 11 1. Human lung growth and development 11 Factors affecting lung growth and development 2. Respiratory distress syndrome (RDS) 12 Clinical presentation and pathology Pulmonary surfactant Surfactant therapy Incidence and prevention of RDS 3. Bronchopulmonary dysplasia (BPD) 14 Old BPD Changing BPD New BPD 3.1. Pathogenesis of BPD 16 Oxygen toxicity Barotrauma volutrama Inflammatory injury Vascular injury Surfactant dysfunction Genetic predisposition 3.2. Incidence of BPD 20 3.3. Prevention and treatment of BPD 21 Optimization of oxygen administration Antioxidant therapy Mode of ventilation Infection/inflammation Pulmonary vascular resistance Nutrition and growth Improving respiratory mechanics, prevention of oedema Glucocorticoids 4. Respiratory morbidity in children born prematurely 24 5. Tests of lung function in infancy and childhood 26 Measures of forced expiratory flow Measures of lung volume Measures of compliance and resistance Measures of gas exchange 6. Lung function in children born prematurely 28 Infancy School age 7. Other indices associated with lung disease 32 Immune response Exhaled nitric oxide (eNO) 8. Follow-up of growth, neurodevelopment and cardiac function in children born prematurely. 34 Growth Neurosensory development Cardiac function
Concomitant Fracture of the Coracoid Process and the Acromion: Report of a Case

A 25-year-old male motorcyclist presented with severe right shoulder pain after a collision with a car. Physical examination revealed gross swelling, bruising, tenderness and restricted range of motion of his right shoulder. Coracoid and acromial fractures were noted. Open reduction and internal fixation were performed. We arranged progressive rehabilitation programs for functional recovery of the shoulder. The recovery was favorable at 1 year of follow-up.
ANTIDIABETIC EFFECT OF JATROPHA CURCAS L. LEAVES EXTRACT IN NORMAL AND ALLOXAN-INDUCED DIABETIC RATS

Jatropha curcas (Euphorbiaceae) is a multipurpose plant with many attributes and considerable potential. Different parts of the jatropha curcas plant are employed in Indian traditional medicine for the treatment of several disorders. Our aim was to investigate the antihyperglycemic effect of 50% ethanolic extract of leaves of jatropha curcas (JCE) in alloxan induced diabetic rats. Oral administration of JCE at a dose of 250 and 500 mg kg -1 bw respectively showed potent antihyperglycemic activity in alloxan induced diabetic rats. The LD50 determination was done in mice by OECD guidelines 423. The LD50 of the JCE was found to be 2500 mg/kg. At the end of treatment, reduction in blood glucose level in treated rats with dose 250 mg/kg was 219.5 – 116.5, (p< 0.001). and oral administration of 500 mg/kg of JCE on blood glucose level was found to be 237.0- 98.83, (p< 0.001). While in case of Glibenclamide 600µg/kg, the results was found to be 232.33 – 94.5 mg/dl, (p< 0.001). Our results indicate that JCE have prominent antidiabetic effect in experimental diabetes and can therefore be used as an alternative remedy for the treatment of diabetes mellitus and its complications.
Mobile applications for people with diabetes published between 2010 and 2015

The use of mobile diabetes self-management applications (apps) is rising. However, current reviews mainly focus on clinically relevant features, and very little on those that affect a user's perception. This review highlights recent developments of these systems, coupled with user perceptions, public presence and availability. After including novel review criteria, we found that most apps have a comprehensive range of features and received good scores from public reviewers. However, the visibility of apps in social media or press is scarce, and few systems are recommended by medical specialists. While we noticed that certified systems are more desired, very few obtained certification or regulatory approval. We foresee that these criteria will be influential in user perceptions and ultimate success of future systems.
The Relationships between e-HRM and Staff Empowerment: A Case Study of Amir Al-Moemenin Hospital in Iran

A B S T R A C T Today, many organizations are concerned with human resources and with the question how information technology can be used in human resource management. The aim of this study was to evaluate the effectiveness of electronic human resource management (independent variable) in terms of education services, health services, and research services, on empowering staff (dependent variable) in Amir Al-Moemenin Hospital of Arak city in Iran. In The study survey method has been used which was supported by a library research. The population consisted of all nurses working in Amir Al-Moemenin hospital in Arak city. The data collected through the questionnaire and for final confirmation, it was presented to a number of experts and professors and validity of Study was confirmed, and also for its reliability, Cronbach's alpha was used. SPSS software was used for data analysis and hypothesis testing. Multivariate regression showed that e-HRM has an impact on empowerment of Manpower in terms of education, health services, and research services.
THE PLACEMENT OF RECTUS SHEATH CATHETERS BY SURGEONS TO REDUCE PAIN FOLLOWING LAPAROTOMY ANAESTHESIA TUTORIAL OF THE WEEK 195

The aim of modern surgical and anaesthetic practice is to facilitate the rapid recovery of patients with better anaesthesia, surgical techniques and analgesia, resulting in fewer complications and earlier return to normal activities. There are multiple techniques available for post-operative analgesia following laparotomy. These include patient controlled analgesia (PCA), epidural analgesia and intermittent injection of local anaesthetic agents via a rectus sheath catheter. All these modalities have risks and benefits that must be considered when planning post-operative pain management. In our institution we are using rectus sheath catheters placed by the operating surgeon with increasing frequency and have found this to be an efficient and safe technique.
Clinical Governance in Primary Care; Principles, Prerequisites and Barriers: a Systematic Review Systematic Review

Introduction: Primary care organizations are entities through which clinical governance is developed at a confined level. To implement clinical governance in primary care, awareness of principles, prerequisites and barriers of this quality improvement paradigm is necessary. The aim of this study is to gather evidence of implementing clinical governance in primary care organizations. Data sources: The primary search was conducted in July 2012. PubMed, Web of Science, Emerald, Springer link, and MD Consult were searched using the following MESH keywords; “clinical governance” and “primary care”. Study selection: The search was limited to English language journals with no time limitation. Articles that were either quantitative or qualitative on the concepts of implementing clinical governance in primary care were eligible for this study. From the selected articles, data on principles, prerequisites and barriers of clinical governance in primary health care were extracted and classified in the extraction tables. Results: We categorized our findings about the principles of clinical governance in primary care in four groups; general principles, principles related to staff, patient and communication. Prerequisites were classified in eight clusters; same as the seven dimensions of the National Health System (NHS) models of clinical governance. Barriers were sorted out in five categories; structure, organizing, cultural, resource, theoretical and logistical. Conclusion: Primary care organizations must provide budget holdings, incentivized programs, data feedback, peer reviews, education, human relations, health information technology (HIT) support, and resources. Key elements include; enrolled populations, interdisciplinary team approach, HIT interoperability and access between all providers and patients, devolution of hospital based services into the community, inter-sectorial integration, blended payments, and a balance of clinical, corporate, and communal governance.