Miracle-dz/UniFAR-FTUs huggingface dataset:
Solving stiffness and deformation of a 3-UPU parallel manipulator with one translation and two rotations

SUMMARY The stiffness modeling and elastic deformation of 3 degrees of freedom, 3-universal joints–prismatic pairs–universal joints (UPU) parallel manipulator (PM) with one translation and two rotations are studied. First, the constraint wrenches are derived corresponding to the special orientation of universal joints in each of the UPU legs. Second, the elastic deformation of active legs produced by these active forces and constrained wrenches are derived. Third, a 6 × 6 Jacobian matrix is derived from constraint and active forces, and the statics is solved. Finally, the stiffness matrix of 3-UPU PM is established and its elastic deformation is solved.
Clinicopathologic Study of Intrapancreatic Cancer Spread in Carcinoma of the Body and Tail of the Pancreas

Objective The aims of this study were to clarify the type of intrapancreatic spread of cancer of the pancreatic body and tail and to assess whether a 2-cm transection margin is adequate to ensure negative margins. Methods We selected 66 patients who underwent distal pancreatectomy for cancer of the pancreatic body and tail. We investigated intrapancreatic cancer spread in these patients histopathologically and analyzed the relationship between 2-cm-margin positivity and other clinicopathological characteristics. Results Two-centimeter-margin positivity was observed in 17 cases. In these, tumors had a tendency to spread toward the pancreatic head along the main pancreatic duct. As a result of statistical analysis, we considered venous invasion (odds ratio [OR], 15.48; 95% confidence interval [CI], 1.61–148.94; P = 0.0177), 2-cm-margin fibrosis (OR, 173.88; 95% CI, 8.96–3375.03; P = 0.0007), and 2-cm-margin hardness (OR, 5.97; 95% CI, 1.07–33.46; P = 0.0420) as being independently related to 2-cm-margin positivity. Conclusions The results suggest that 2 cm is not a safe length to ensure a negative margin. In the future, preoperative and intraoperative evaluation of the degree of fibrosis of pancreatic parenchyma could lead to cancer-free pancreatic cut-end margins.
Organic-Transistor-Based Nano-Floating-Gate Memory Devices Having Multistack Charge-Trapping Layers

Nano-floating-gate memory devices having multistack charge-trapping layers are developed. Controlled gold nanoparticles encapsulated with polyelectrolytes are used as charge-trapping elements. Programmable memory characteristics are observed according to the programming/erasing operations in pentacene-based organic-transistor memory devices. The memory window can be increased effectively by the adoption of multistack charge-trapping layers. The data-retention measurement shows that the programmed/erased states are maintained relatively well according to the time elapsed. This letter is based on simple solution processes at low temperature, so it has a potential use in fabricating nano-floating-gate memory devices on plastic substrates.
Community-acquired methicillin-resistant Staphylococcus aureus infections in South Texas children

Background. Community-acquired methicillin-resistant Staphylococcus aureus (CAMRSA) infections have increased dramatically from 1990 to 2000. Objectives. The objectives of this retrospective study were to report the frequency of CAMRSA isolates, to describe the spectrum of disease observed in children infected with CAMRSA and to compare the antibiotic susceptibility patterns of community-acquired and nosocomial methicillin-resistant S. aureus (MRSA) infections. Methods. All cases of S. aureus including MRSA infections were identified by a computer-assisted search of the Vitek system culture results from 1990 to 2000 and review of the minutes of Infection Control Committee meetings. Results. MRSA was isolated from 147 children (77 boys; 2 weeks to 17 years) from October 1, 1990, to December 31, 2000. Seven cases of CAMRSA were identified from 1990 to 1996, and 53 cases were identified from 1997 to 2000 with 35 cases occurring in 2000. Of the 128 children whose medical records were reviewed, 60 (47%) had CAMRSA infections. In 53 (88%) of these 60 children no risk factor for MRSA was identified. Soft tissue infections accounted for 48 (91%) of the 53 cases of the CAMRSA in children without known risk factors. CAMRSA isolates from children without known risk factors were more susceptible to trimethoprim-sulfamethoxazole (98%vs. 82%;P < 0.005) and clindamycin (92%vs. 57%;P < 0.001) and less susceptible to tetracycline (54%vs. 95%;P < 0.001) than were nosocomial MRSA isolates. Conclusions. The emergence of CAMRSA as a cause of common infections may require a change in the initial selection of antibiotics to assure appropriate coverage in critically ill children.
Host Chaperones Are Recruited in Membrane-bound Complexes byPlasmodium falciparum *

The ability of malarial parasite to deploy proteins at the surface of infected erythrocytes is well known. After their synthesis within the parasite, the cargo proteins are exported from the parasite and carried across the erythrocyte cytoplasm to be delivered at the erythrocyte surface. Our knowledge about the mechanisms involved in this complex trafficking path is limited. We have addressed the involvement of chaperones in traffic across erythrocyte cytoplasm. Our analyses of the chaperones available to the parasite indicated that none of the reported chaperones of the parasite origin are present in the erythrocyte cytoplasm. The chaperones of the host (Hsp70, Hsp90, Hop60), on the other hand, were readily detected in the erythrocyte cytosol. Hypotonic lysis and detergent solubilization experiments indicated that unlike their soluble nature in normal erythrocytes, host chaperones are recruited in membrane-bound, detergent-resistant complexes in infected cells. The association of host-Hsp70 with detergent-resistant complexes was ATP-dependent. Importantly, host chaperones could be detected in knob-enriched fractions and could be cross-linked to the knob subunit, PfHRP1, in a large complex at the surface of the infected erythrocytes. Our results implicate host chaperones in the assembly of parasite proteins such as knob subunits at the erythrocyte surface.
Interfacial Hydrogen Bonds and Their Influence Mechanism on Increasing the Thermal Stability of Nano-SiO2-Modified Meta-Aramid Fibres

For further analysis of the effect of nano-doping on the properties of high polymers and research into the mechanism behind modified interfacial hydrogen bonds, a study on the formation probability of nano-SiO2/meta-aramid fibre interfacial hydrogen bonds and the strengthening mechanism behind interfacial hydrogen bonds on the thermal stability of meta-aramid fibres using molecular dynamics is performed in this paper. First, the pure meta-aramid fibre and nano-SiO2/meta-aramid fibre mixed models with nanoparticle radiuses of 3, 5, 7 and 9 Å (1 Å = 10−1 nm) are built, and then the optimization process and dynamics simulation of the models are conducted. The dynamics simulation results indicate that the number of hydrogen bonds increase due to the doping by nano-SiO2 and that the number of interfacial hydrogen bonds increases with the nanoparticle radius. By analysing the hydrogen bond formation probability of all the atom pairs in the mixed model with pair correlation functions (PCFs), it can be observed that the hydrogen bond formation probability between the oxygen atom and hydrogen atom on the nanoparticle surface is the greatest. An effective way to increase the number of interfacial hydrogen bonds in nano-SiO2 and meta-aramid fibres is to increase the number of hydrogen atoms on the nano-silica surface and oxygen atoms in the meta-aramid fibre. By using the radial distribution function (RDF), the conclusion can be further drawn that the hydrogen bond formation probability is at a maximum when the atomic distance is 2.7–2.8 Å; therefore, increasing the number of atoms within this range can significantly increase the formation probability of hydrogen bonds. According to the results of chain movement, the existence of interfacial hydrogen bonds effectively limits the free movement of the molecular chains of meta-aramid fibres and enhances the thermal stability of meta-aramid fibres. The existence of interfacial hydrogen bonds is one of the important reasons for formation of the stable interface structure between nanoparticles and meta-aramid fibres. In addition, a nanoparticle with a small radius improves the interfacial hydrogen bond energy density and interfacial interaction energy density, enhancing the stability of the mixed model interface.
Maximal Treadmill Versus Cycle Ergometry Testing in Children: Differences, Reliability, and Variability of Responses

This study was designed to determine the differing cardiorespiratory responses between maximal treadmill (TM) and cycle (CY) ergometry, and the reliability and variability of these responses in 46 children 7 to 9 years old (23 boys and 23 girls). Two maximal TM and two maximal CY tests were administered, as well as a body composition assessment. The TM resulted in a 9.4%, 11,1%, and 10.2% higher maximal oxygen consumption values (VO2, ml·kg−1·min−1) than the CY in boys, girls, and the total population, respectively. Both the TM and the CY proved to be reliable measures of maximal VO2 (ml·kg−1·min−1) in both boys and girls, with intraclass correlations ranging from R = . 63 to . 90. Variability was significantly less (p ≤ .05) on the CY (VO2 in L·min−1) than the TM, 4.4% versus 6.2%, respectively.
Non Commutative Quantum Mechanics in Time - Dependent Backgrounds

The problem of the dissipative systems from the quantum point of view has been of increasing interest, but it is far from having a satisfactory solution (1). There are many problems where the dissipation has an important role such as in quantum optics, in quantum analysis of fields, in quantum gravity (2). Dissipation can be observed in interactions between two systems, the observed system and another one often called reservoir or the bath, into which the energy flows via an irreversiblemanner (3). The system is embedded in some environmentwhich is in principle unknown. For an effective description of such systems, we can use time dependent Hamiltonians which in classical physics yield the proper equation of motion. If the friction is a linear funcion of the velocity with friction constant γ the Hamiltonian is the well known Caldirola Kanai Hamiltonian
Evolution of smart metering systems

Intelligent buildings are difficult to imagine nowadays without smart metering devices. Smart metering provides commodity consumption information on electricity, gas and water. This information is also made available to the customers in order to help them in the reduction of energy consumption, costs and CO2 emission. Energy consumption can be adapted dynamically using smart metering devices to balance the power generation and distribution in the smart grid. Evolution of smart metering systems is reviewed in this paper. Smart metering projects completed in Europe are listed together with their aims and objectives. Security issues in smart metering systems are highlighted in the paper. Finally, some of the communication protocols and standards for smart metering devices are discussed in the paper.
Sibs with mental and physical retardation and trichorrhexis nodosa with abnormal amino acid composition of the hair.

Trichorrhexis nodosa is a condition in which individual hairs develop areas where the shaft has split longitudinally into numerous small fibres. The hairs eventually break at these points leaving brush-like ends. Usually trichorrhexis nodosa results from mechanical trauma or harsh chemical treatment (Chernosky and Owens, 1966), but two inherited disorders, argininosuccinic aciduria (Allan et al., 1958; Levin, Mackay, and Oberholzer, 1961; Westall, 1960) and a type of sex-linked neurodegeneration (Menkes et al., 1962), are often associated with a very marked degree of trichorrhexis nodosa. This is a report of a brother and sister with another syndrome, showing mental and physical retardation, trichorrhexis nodosa, and other hair defects.
Apoptosis induced by progesterone in human ovarian cancer cell line SNU‐840

Progesterone has been used as an ingredient of anticancer drug for patients with ovarian carcinoma. However, the mechanism of anticancer effects by progesterone has not been understood. In this study, the effects of progesterone on ovarian cancer cells, SNU‐840, were investigated. After the incubation with progesterone, the viability of the cells was evaluated by MTT assay. As a result, 45% of the cells were viable after 48 h of incubation with 100 μM progesterone. In addition, [3H]thymidine incorporation assay showed that the proliferation of the cells was completely inhibited by progesterone after 48 h of incubation at 100 μM concentration. Colorimetric TUNEL assay revealed the fragmentation of the chromosomal DNA, suggesting that the process of the cell death was apoptosis. The level of the p53 mRNA was determined by northern blotting assay, since many apoptosis processes are mediated by up‐regulation of the p53 expression. The level of the p53 mRNA reached its maximum at 12 h and decreased after 24 h of incubation with progesterone. In conclusion, progesterone inhibits the proliferation and elicites apoptosis of SNU‐840 cells. Also, it up‐regulates the p53 mRNA transiently. J. Cell. Biochem. 82:445–451, 2001. © 2001 Wiley‐Liss, Inc.
Acute Administration of Estrogen and Progesterone Impairs the Acquisition of the Spatial Morris Water Maze in Ovariectomized Rats

Although several markers of synaptic efficacy are enhanced during proestrus, spatial water maze performance is impaired. Because levels of both estrogen and progesterone are elevated in proestrus, the nature of their individual and combined effects on spatial learning was examined. Long-Evans hooded rats were ovariectomized postpubertally and pretrained on a water maze with a visible platform (nonspatial). Following pretraining, rats were administered estrogen (5 microg sc) or oil 48 and 24 h prior to testing and progesterone (500 microg sc) or oil 4 h prior to testing. Rats were tested on a water maze in a different room with a submerged platform (spatial) for 16 trials with random start location in a single testing day. Latency and path length to the target platform were significantly greater in estrogen plus progesterone-treated animals than in controls. Neither estrogen nor progesterone alone significantly impaired performance relative to controls on either measure. Swim speed was not significantly affected by any of the hormone treatments. Performance on a nonspatial cue task was not significantly altered by ovarian steroids. Thus, the combination of estrogen and progesterone produces deficits in the acquisition of the Morris water maze that may be specific to spatial reference memory. These deficits could be due to hormonal influences on extrahippocampal structures or to detrimental effects on behavior resulting from the increased synaptic activity intrinsic to the hippocampus proper.
Improving Adolescent Parenting: Results From a Randomized Controlled Trial of a Home Visiting Program for Young Families.

OBJECTIVES Our aim was to estimate the effects of Healthy Families Massachusetts, a statewide home visiting program serving first-time adolescent parents, on parenting, child development, educational attainment, family planning, and maternal health and well-being. METHODS We used a randomized controlled trial design to randomly assign the 704 participants to a group receiving home visiting services or a control group. Between 2008 and 2012, telephone and in-person interviews were conducted and administrative data obtained at 12 and 24 months after enrollment. Intention-to-treat analyses compared group differences across 5 outcome domains: parenting, child health and development, educational and economic achievement, family planning, and parental health and well-being. RESULTS The home visiting program had a positive influence on parenting stress, college attendance, condom use, intimate partner violence, and engagement in risky behaviors. No negative findings were observed. CONCLUSIONS A paraprofessional home visiting program specifically targeting young mothers appears effective in domains of particular salience to young parents and their infants and toddlers. Expanding participation in the program appears a worthy goal for program administrators and policymakers.
Modified radical hysterectomy in the treatment of early squamous cervical cancer.

OBJECTIVE The aim of this study was to evaluate the results of modified radical hysterectomy in the treatment of early cervical cancer. MATERIAL AND METHODS A retrospective chart review of 56 patients with stage I (IA in 35, IB in 21) squamous cervical carcinoma treated with modified radical hysterectomy and followed for a minimum of 5 years (mean, 12 years; range, 5.1-29) was conducted. All pathology slides were reviewed for tumor size, grade, depth of invasion, and lymph-vascular permeation. RESULTS The mean depth of invasion was 0.5 cm (range, 0.1-2.5 cm), and the mean tumor size was 1.1 cm (range, 0.1-7 cm). Only 3 patients (5.4%) had positive nodes. None of the patients with tumors 2 cm or less in size had positive nodes, whereas 33.3% of the patients with tumors more than 2 cm in size had positive nodes. A recurrence developed in 2 patients (5-year recurrence rate of 3.6%). There were 10 deaths during the entire follow-up period, but only 2 were related to cervical cancer. The disease-specific and overall 5-year survival rates were 96.4 and 94.6%, respectively. The disease-specific 5-year survival rate was 100% among the 47 patients with tumors 2 cm or less and 75% for the 9 patients with tumors larger than 2 cm. Univariate analysis identified stage, lymph node status, and tumor size as statistically significant prognostic factors for overall survival. Tumor grade, lymph-vascular permeation, and depth of invasion (1-3 mm vs >3 mm) were not statistically significant for overall survival. CONCLUSIONS Modified radical hysterectomy appears to be effective surgical therapy for patients with squamous cervical carcinoma 2 cm or less in size.
Kobe University Repository : Kernel タイトル Tit le Recombinant Protein Product ion by the Baculovirus-Insect Cell System in Basal Media Without Serum

Tit le Recombinant Protein Product ion by the BaculovirusInsect Cell System in Basal Media Without Serum Supplementat ion Author(s) Nishikawa, Norikatsu / Yamaji, Hideki / Fukuda, Hideki Citat ion Cytotechnology,43( 1-3):3-10 Issue date 2003-11 Resource Type Journal Art icle / 学術雑誌論文 Resource Version author DOI 10.1023/B:CYTO.0000039894. 27256.0f URL http://www.lib. kobe-u.ac. jp/handle_kernel/90000168
Glycoxidation of Low‐Density Lipoprotein Increases TUNEL Positivity and CPP32 Activation in Human Coronary Cells

Abstract: Apoptosis of arterial cells induced by oxidized low‐density lipoprotein (oxLDL) is thought to contribute to the progression of vascular dysfunction and atherogenesis. It is well established that diabetes mellitus is accompanied by both glycosylation and oxidation of LDL (glc‐oxLDL), but the biological effects of these modified lipoproteins are poorly understood. We demonstrate here for the first time that glc‐oxLDL increases TUNEL positivity and caspase‐3 activation (by Western blot and immunocytochemistry) of human coronary smooth muscle cells. Overall, these effects induced by glc‐oxLDL were greater than those achieved with oxLDL. Thus, glc‐oxLDL activated downstream apoptotic signaling. This may influence the evolution of atherogenesis and vascular complications in diabetes.
Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload.

BACKGROUND & AIMS Imbalances of iron homeostasis are accompanied by alterations of intestinal iron absorption. The identification of divalent-metal transporter 1 (DMT1) and ferroportin 1 (FP1) has improved our understanding of transmembrane iron trafficking. To gain insight into the regulatory properties of these transporters in the duodenum, we studied their expression in patients with hereditary hemochromatosis (HFE-associated and non-HFE-associated), secondary iron overload, and iron deficiency. METHODS DMT1, FP1 messenger RNA (mRNA), and protein expression were analyzed in duodenal biopsy specimens from patients by means of TaqMan real-time polymerase chain reaction, Western blotting technique, and immunohistochemistry. RESULTS DMT1 and FP1 mRNA levels are positively correlated with each other in all patient groups (P < 0.001). Moreover, DMT1 and FP1 mRNA levels were significantly increased in patients with iron deficiency, HFE and non-HFE hemochromatosis, whereas they were unchanged in patients with secondary iron overload. Alterations in DMT1 and FP1 mRNA levels were paralleled by comparable changes in the duodenal expression of these proteins. In patients with normal iron status or iron deficiency, significant negative correlations between DMT1, FP1 mRNA, and serum iron parameters were found, which were absent in subjects with primary hemochromatosis. CONCLUSIONS DMT1 and FP1 are centrally involved in iron uptake/transfer in the duodenum and in the adaptive changes of iron homeostasis to iron deficiency and overload.
Auto Transplantation of a Mandibular Third Molar with Complete Root Development - A Case Report?

Autogenous transplantation is an economical as well as the most sorted option for the treatment of badly destroyed teeth when a suitable donor tooth is available. This paper presents successful auto transplantation of a mature mandibular right third molar (48) without anatomical variance is used to replace a grossly decayed mandibular right first molar (46). The mandibular first molar was nonrestorable due to extensive root caries. After extraction of mandibular first molar, root canal therapy was done for the third molar extraorally, and the tooth was reimplanted into the recipient site. After 1.8 years, clinical and radiographic examination revealed satisfactory outcome with no signs or symptoms suggestive of pathology. In selected cases, autogenous tooth transplantation, even after complete root formation of the donor tooth, may be considered as a practical treatment alternative to conventional prosthetic rehabilitation or implant treatment.
Prephenate Dehydratase from the Aphid Endosymbiont (Buchnera) Displays Changes in the Regulatory Domain That Suggest Its Desensitization to Inhibition by Phenylalanine

ABSTRACT Buchnera aphidicola, the prokaryotic endosymbiont of aphids, complements dietary deficiencies with the synthesis and provision of several essential amino acids. We have cloned and sequenced a region of the genome of B. aphidicola isolated from Acyrthosiphon pisum which includes the two-domainaroQ/pheA gene. This gene encodes the bifunctional chorismate mutase-prephenate dehydratase protein, which plays a central role in l-phenylalanine biosynthesis. Two changes involved in the overproduction of this amino acid have been detected. First, the absence of an attenuator region suggests a constitutive expression of this gene. Second, the regulatory domain of the Buchneraprephenate dehydratase shows changes in the ESRP sequence, which is involved in the allosteric binding of phenylalanine and is strongly conserved in prephenate dehydratase proteins from practically all known organisms. These changes suggest the desensitization of the enzyme to inhibition by phenylalanine and would permit the bacterial endosymbiont to overproduce phenylalanine.