Miracle-dz/UniFAR-FTUs huggingface dataset:
Mammalian growth-associated H1 histone kinase: a homolog of cdc2+/CDC28 protein kinases controlling mitotic entry in yeast and frog cells

Mammalian growth-associated H1 histone kinase, an enzyme whose activity is sharply elevated at mitosis, is similar to cdc2+ protein kinase from Schizosaccharomyces pombe and CDC28 protein kinase from Saccharomyces cerevisiae with respect to immunoreactivity, molecular size, and specificity for phosphorylation sites in H1 histone. Phosphorylation of specific growth-associated sites in H1 histone is catalyzed by yeast cdc2+/CDC28 kinase, as shown by the in vitro thermal lability of this activity in extracts prepared from temperature-sensitive mutants. In addition, highly purified Xenopus maturation-promoting factor catalyzes phosphorylation of the same sites in H1 as do the mammalian and yeast kinases. The data indicate that growth-associated H1 kinase is encoded by a mammalian homolog of cdc2+/CDC28 protein kinase, which controls entry into mitosis in yeast and frog cells. Since H1 histone is known to be an in vivo substrate of the mammalian kinase, this suggests that phosphorylation of H1 histone or an H1 histone counterpart is an important component of the mechanism for entry of cells into mitosis.
Worker Training and Competing on Product Quality

We examine the relationship between firm-sponsored training and the sensitivity of product demand to product quality. A quality-adjusted model of monopolistic competition shows the conditions under which the intensity of training increases as product demand becomes more sensitive to quality. Empirical estimates from two cross sections and a panel of British establishments as well as from two matched employee cross sections confirm that training is more intensive when product demand is more sensitive to quality.
Efficacy and Safety of Endoscopic Balloon Dilation of Symptomatic Upper and Lower Gastrointestinal Crohn's Disease Strictures

Goals: To evaluate efficacy and safety of endoscopic balloon dilation with or without intralesional steroid injection, of symptomatic upper gastrointestinal (UGI) and lower gastrointestinal (LGI) Crohn's disease (CD) strictures. Background: Patients with CD commonly develop obstructive symptoms secondary to gastrointestinal strictures. When these do not resolve with medical management, surgery is usually the only alternative. Limited data are available on the safety and efficacy of endoscopic through-the-scope (TTS) balloon dilation of CD strictures. Study: We performed a retrospective review of TTS balloon dilations done on CD-related UGI and LGI strictures. Postdilation intralesional steroid injections were done at the discretion of the endoscopist. Stricture was defined as luminal stenosis <10 mm in diameter, through which a scope could not be passed. Technical success was defined as the ability of the scope to traverse the stricture postdilation. Long-term success rate was claimed if a patient remained asymptomatic and did not require surgery or further endoscopic dilation. Results: Over 4 years, we performed 29 stricture dilations on 17 patients (10 female, 7 male) with 20 strictures. The mean follow-up period was 18.8 months (range, 5-50 months). Stricture locations were as follows: rectal, 5; sigmoid colon, 2; colo-colonic anastomosis, 3; ileocolonic anastomosis, 4; ileum, 1; descending colon, 1; cecum, 1; and distal duodenal bulb, 3 patients. Technical success was achieved in 28 of 29 stricture dilations (96.5%). Ten strictures (34.5%) were dilated to <15 mm and 19 (65.5%) to ≥15 mm diameter. Long-term success rate in the <15 mm group was 70%, and in ≥15 mm group was 68.4%. Four quadrant steroid injections were done on 11 strictures. The recurrence rate in this group was 10% and that in the nonsteroid group was 31.3%. The overall long-term success rate was 76.5% by intent-to-treat analysis. Three perforations occurred (all colonic) during 29 stricture dilations, a complication rate of 10% with no mortalities. Conclusion: We report the first series of TTS balloon dilations with or without intralesional steroid injection, of both primary and anastomotic UGI and LGI strictures in CD patients. Long-term success was achieved in 76.5% patients with a complication rate of 10%. This mode of therapy appears safe and effective and can be considered as an alternative to surgery in selected patients with medically refractory CD-associated GI strictures. Success rates were better in patients who received four quadrant steroid injections. No difference was seen in stricture recurrence rate or complications based on diameter of TTS balloon used.
Pelvic exenteration: effects of surgery on quality of life and body image--a prospective longitudinal study.

OBJECTIVES The goal of this study was to evaluate the impact of reconstructive and nonreconstructive surgical procedures on quality of life and body image for women who undergo pelvic exenteration. METHODS Twenty-eight patients were assessed in a prospective study with a preoperative semistructured interview and an objective assessment (T1). Interviews and questionnaires were repeated 4 (T2) and 12 (T3) months postoperatively. The women were divided into groups with two, one, or no ostomies. A separate comparison was made of women with and without vaginal capacity. Quality of life was defined in terms of five categories according to the definition of health proposed by the World Health Organization: physical and psychosocial health; marital and sexual status; medical interactions. RESULTS At all points in time, the patients' quality of life was affected most significantly by worries about the progression of the tumor. Twelve months postoperatively, patients with two ostomies reported a significantly lower quality of life (P = 0.008) and poorer body image (P = 0.002) than patients with no ostomy. At T3, patients with vaginal capacity reported fewer problems in all categories related to quality of life and significantly (P = 0.015) fewer sexual problems. CONCLUSION An evaluation of quality of life and body image demonstrates the benefits of newer techniques for organ reconstruction. Thus, organ reconstruction should be performed whenever possible in patients with pelvic exenteration.
The effect of sponsorship on the market value of firms in Australia: Event study findings

Event studies of sponsorship announcements made by large firms in the United States show that in most instances sponsorship-linked marketing contributes to the creation of shareholder value for the sponsoring firm. Much less is known about the effects of sponsorship upon shareholder value in small markets. This event study of 51 sponsorship announcements made by firms listed on the Australian Stock Exchange found that the sampled firms experienced a small, positive increase in firm value of 0.31 percent at the time of the sponsorship announcement. A comparison of sponsorship announcements made prior to the Sydney 2000 Olympic Games with announcements made from 2001on showed no change in investor perceptions of sponsorship. While investors appeared indifferent to any of the sponsorship contract amounts examined, shorter sponsorships were marginally preferred over medium or long-term contracts. This suggests that marketing campaigns that focus on short, flexible sponsorship campaigns may prove the most effective strategy financially.
Generation and adaptation of robot skills models

Humanoid robots are required to perform a wide repertoire of task working beside humans in complex dynamic environments. Learning mechanism are important for building up this type of repertoires of robot skills, however, despite the clear advantages of this approaches it would be impractical to teach the robot skills for every needed task and for every foreseen situation. Robot skills learning approaches to develop humanoid robotic systems would have greater impact if the models of the skill can be operated upon to generate new behaviours of increasing levels of complexity. A framework that allows the adaptation of a robot previously learned motion skills to new unseen contexts is necessary. In this work we present different modalities for the adaptation and generation of new skill models based on the already learned models of skills. Experimental results are presented to validate this approach.
Regulation of Amylase-Glucose-Insulin via Dietary Supplemental of Zinc in Weanling Pigs

The impact of supplemental Zinc on Amylase – Glucose Insulin regulation were studied in 15 numbers of weanling pigs 87.50 percent Hampshire (Hampshire X Meghalaya local) weaned at 60 days of age, apparently healthy with uniform body weight (10.60 to 10.70 kg) were selected for the experiment and were randomly allocated into 3 treatment groups viz. Group A (100ppm Zn ) as per the recommendation of NRC (1998) which was considered as control, B (200ppm Zn) and C (300ppm Zn) comprising 5 weanling pigs in each group. The experiment was conducted for a period of 4 months (2 to 6 months of age). The body weight gain (BWG) was measured and serum sample were collected at fortnightly interval from 2 to 6 months of age. The BWG, serum zinc concentration, amylase activity and insulin concentration was found significantly (P<0.01) higher in group C followed by B whereas the lowest was in group A at the end of the experiment (6 month of age). Significantly (P<0.01) highest serum glucose concentration was observed in A group whereas, lowest was in C group. The variations in response to dietary supplemental zinc among treatments could be related to the stimulation of Amylase Glucose – insulin pathway by dietary zinc supplementation to enhance the body weight.
The Relationship between High Performance Work Practices and Organizational Citizenship Behavior: The Role of Positive Psychological Capital

The global competition and advancements in Information Technology have stimulated implementation of innovative HR practices, often termed as High Performance Work Practices (HPWP) to improve the performance of the employees. HPWP may be regarded as a combination of innovative HR practices which tend to maximize employee knowledge, skills and performance of the employees which in turn leads to persistent performance improvements resulting in employee satisfaction and a sense of personal achievement.The present study seeks to analyze the relationship of implementing High Performance Work Practices on the Organizational Citizenship Behavior (OCB) of the employees. OCB includes such individual behaviors that are beneficial to the organization but not directly recognized by the formal reward system and can contribute to performance and competitive advantage. Positive Psychological Capital is defined as the positive and developmental state of an individual. In the present study, the role of Positive Psychological Behavior (Psycap) on the HPWP and OCB relationship is being analyzed.
Unmet need in mental health provision

The rise in out of area placements is the result of having cut 72% of England’s mental health beds since 1987 and is emblematic of increasing unmet need in mental health provision.1 Thousands more patients are being denied any bed, as admission thresholds inevitably rise. Who is monitoring harms in these patients, in terms of avoidable deterioration, injurious behaviour, and suicide? The Department of Health, NHS Improvement and NHS England, and the …
Phytophthora cinnamomi.

SUMMARY Phytophthora cinnamomi Rands was first isolated from cinnamon trees in Sumatra in 1922. The pathogen is believed to have originated near Papua New Guinea but now has a worldwide distribution. P. cinnamomi is heterothallic with A1 and A2 mating types; however, even in areas in which both mating types are present, it appears that genetic diversity arises asexually rather than as a result of sexual recombination. P. cinnamomi can grow saprophytically in the soil for long periods, rapidly capitalizing on the advent of favourable conditions to sporulate and produce vast numbers of asexual, biflagellate zoospores. The motile zoospores are attracted to suitable infection sites, where they attach and invade the plant. Within a few days, hyphae ramify throughout the tissues of susceptible plants, forming sporangia on the plant surface and rapidly amplifying the disease inoculum. Over the last 10-15 years, molecular analyses have clarified details of the phylogeny of P. cinnamomi and other Oomycetes. Research on P. cinnamomi has given rise to a more comprehensive understanding of the structure and function of the motile zoospores. New methods have been developed for P. cinnamomi identification and diagnosis. Long-term studies of diseased sites, particular those in southern Australia, have produced a better understanding of the epidemiology of P. cinnamomi diseases. Research has also increased our knowledge of the mode of action and efficacy of inhibitors of P. cinnamomi diseases, especially the phosphonates. This review will present an overview of the advances these studies have made in our understanding of P. cinnamomi pathogenicity, epidemiology and control. TAXONOMY Phytophthora cinnamomi Rands; kingdom Chromista; phylum Oomycota; order Peronosporales; family Peronosporaceae; genus Phytophthora. HOST RANGE Likely to infect in excess of 3000 species of plants including over 2500 Australian native species, and crops such as avocado, pineapple, peach, chestnut and macadamia. Disease symptoms: A root pathogen which usually causes rotting of fine and fibrous roots but which can also cause stem cankers. Often causes dieback of young shoots and is thought to do so as a result of interference with transpiration from roots to shoots. USEFUL WEBSITES http://genome.jgi-psf.org/physo00.info.html; http://phytophthora.vbi. vt.edu.
A study of voluntary administration: statistical model predictions and experts' judgements regarding the reorganisation decision and success of reorganised companies

The voluntary administration procedure, embodied in Part 5.3A of the Corporations Law, was introduced as part of Australia's corporate insolvency regime in June 1993. Voluntary administration has become the most widely used means of dealing with corporate insolvency in Australia since its inception. Since the inception of voluntary administration there has been little empirical research conducted to analyse the operation and effect of the legislation's provision for company reorganisation. Critical to the efficient operation of reorganisation legislation is the decision regarding which companies should be permitted to attempt reorganisation. Returning inefficient firms to the market may result in economic costs that are greater than the benefits derived from saving a few distressed companies.This thesis focuses on the reorganisation decision. A statistical model is developed, based on the coalition behaviour decision theory which provides some insight into the behaviour of parties involved in the reorganisation decision. A further statistical model is developed that addresses the problem of identifying suitable (successful) reorganisation candidates from a pool of distressed companies. This model should be of value to those required to decide which companies should attempt reorganisation. Improved understanding of what contributes to success in company reorganisation may be useful in minimising the incidence of reorganisation of inefficinet companies. This thesis also examines the relationship between information cues and insolvency experts' decisions regarding companies' prospects in reorganisation. The findings presented in this thesis have implications for insolvency policy that adopts a flexible regime for company reorganisation, which is a feature of the Australian voluntary administration law. ; Submitted in fulfillment of the degree of Doctor of Philosophy, University of the Sunshine Coast, 2000.
Strategic Asset Allocation and Portfolio Performance

This paper examines the impact of strategic asset allocation on total returns of investment portfolios. It aims to confirm the results of previous studies using US investment data that found strategic asset allocation dominating the other investment decisions namely market timing and security selection. Using data from Australian managed funds, strategic asset allocation is found to account for most of the total returns in terms of magnitude and around 88% of the variability in total portfolio returns. Suggestions are made to expand the scope of the study to be able to generate more conclusive results.
Evaluating the Memorability and Readability of Micro-filter Visualisations

When using classical search engines, researchers are often confronted with a number of results far beyond what they can realistically manage to read; when this happens, recommender systems can help, by pointing users to the most valuable sources of information. In the course of a long-term research project, research into one area can extend over several days, weeks, or even months. Interruptions are unavoidable, and, when multiple team members have to discuss the status of a project, it’s important to be able to communicate the current research status easily and accurately. Multiple type-specific interactive views can help users identify the results most relevant to their focus of interest. Our recommendation dashboard uses micro-filter visualizations intended to improve the experience of working with multiple active filters, allowing researchers to maintain an overview of their progress. Within this paper, we carry out an evaluation of whether micro-visualizations help to increase the memorability and readability of active filters in comparison to textual filters. Five tasks, quantitative and qualitative questions, and the separate view on the different visualisation types enabled us to gain insights on how micro-visualisations behave and will be discussed throughout the paper.
DVB-T2: Optionen für Deutschland

Die zweite Generation des DVB(Digital Video Broadcasting) Standards für die digitale terrestrische Fernsehausstrahlung (DVB-T2) wurde mit Hilfe eines Toolbox-Konzepts entwickelt. Verglichen mit seinem Vorgänger DVB-T enthält der neue Standard viele neue Algorithmen und ermöglicht eine flexible Parameterauswahl. Die Parameter lassen sich perfekt für jedes Empfangsszenario optimieren, ausgehend vom stationären Empfang mit Dachantennen, bis hin zum portablen oder mobilen Empfang. Viele Länder haben bereits DVB-T2 eingeführt. Die Netze wurden aber vor allem für den stationären Empfang optimiert. Im Gegensatz dazu ist der stationäre Empfang keine relevante Option für eine mögliche Nutzung von DVB-T2 in Deutschland. Eine eventuelle Einführung würde sich auf die Vorteile des terrestrischen Rundfunks im Vergleich zu Satellit und Kabel konzentrieren, d. h die Möglichkeit, mit portablen und mobilen Empfängern TV-Programme zu nutzen. Innerhalb eines umfangreichen Feldversuchs in Norddeutschland wurde die Leistung der unterschiedlichen Parameter-Konfigurationen und der neuen Algorithmen von DVB-T2 z. B. M-PLP (Multiple Physical Layer Pipes), Rotated Constellations, MISO (Multiple Input Single Output) im Detail analysiert. Dieser Beitrag stellt den Modellversuch und dessen Ergebnisse vor, die auf Tausenden von Einzelmessungen beruhen. Darüber hinaus gibt das Dokument einen kurzen Überblick über die optimalen Parameter-Konfigurationen für Deutschland.
THE EFFECT OF REAL EARNINGS MANAGEMENT ON THE VALUE RELEVANCE OF EARNINGS, BOOK VALUE OF EQUITY, AND CASH FLOW FROM OPERATIONS

This study investigates the impact of real earnings management on value relevance of earnings, book value of equity, and cash flow from operations. The study uses price model i.e. stock price as firm value. The real earnings management is measured by abnormal cash flow of operation (Abn.CFO), abnormal cash production costs (Abn.PROD), and abnormal cash discretionary expenses (Abn.DISCR) as real earnings management proxy. The sample of this study is manufacturing sector companies listed in Indonesian Stock Exchange (IDX). Regression analyses on a sample of 312 firm-years from 2011 to 2013 are employed to test hypotheses. The result of the test shows that earnings, book value of equity, and cash flow from operations are relevant to measure firm value. The value relevance decreased when firms engaged in real earnings management. This is because real earnings management will reduce the quality of the financial statements. When the financial statements do not have good quality, then users will prefer to use other reports that are more relevant in making a decision. Key words : earnings, book value of equity, cash flow from operation, stock price, abnormal cash flow of operation, abnormal production cost, and abnormal discretionary expenses.
The Thai Dairy Industry: Its Economic Evolution Raised by Land Rights and Cattle Diseases

Changes in the economic, demographic and political characteristics of Thailand have had a strong impact on the traditional nature of Thailand’s agriculture and livestock industries over the last few decades. This paper outlines the development of the Thai dairy industry and discusses economic factors, including government policies, influencing its development. Land rights have affected its development, e.g. the availability of credit to dairy farmers. In addition, the small size of Thai farms and lack of a ready market in land has resulted in small herd sizes. Furthermore, the extensive use of common property resources has implications for resource management and sustainable agricultural development in Thailand. A number of environmental issues are considered, associated with raising dairy cattle and other livestock in Thailand. The growth of the Thai industry highlights the urgency of cattle disease control, especially the control or eradication of particular diseases. The policy implications of this are discussed.
How Oligomerization Contributes to the Thermostability of an Archaeon Protein

To study how oligomerization may contribute to the thermostability of archaeon proteins, we focused on a hexameric protein, protein l-isoaspartyl-O-methyltransferase from Sulfolobus tokodaii (StoPIMT). The crystal structure shows that StoPIMT has a distinctive hexameric structure composed of monomers consisting of two domains: an S-adenosylmethionine-dependent methyltransferase fold domain and a C-terminal α-helical domain. The hexameric structure includes three interfacial contact regions: major, minor, and coiled-coil. Several C-terminal deletion mutants were constructed and characterized. The hexameric structure and thermostability were retained when the C-terminal α-helical domain (Tyr206-Thr231) was deleted, suggesting that oligomerization via coiled-coil association using the C-terminal α-helical domains did not contribute critically to hexamerization or to the increased thermostability of the protein. Deletion of three additional residues located in the major contact region, Tyr203-Asp204-Asp205, led to a significant decrease in hexamer stability and chemico/thermostability. Although replacement of Thr146 and Asp204, which form two hydrogen bonds in the interface in the major contact region, with Ala did not affect hexamer formation, these mutations led to a significant decrease in thermostability, suggesting that two residues in the major contact region make significant contributions to the increase in stability of the protein via hexamerization. These results suggest that cooperative hexamerization occurs via interactions of “hot spot” residues and that a couple of interfacial hot spot residues are responsible for enhancing thermostability via oligomerization.