Miracle-dz/UniFAR-FTUs huggingface dataset:
Penerapan Data Mining Untuk Menganalisis Kepuasan Konsumen Menggunakan Metode Algoritma C4.5

Kepuasan konsumen mencakup perbedaan antara tingkat kepentingan dan kinerja atau hasil yang dirasakan, serta merupakan evaluasi purna beli dimana alternatif yang dipilih sekurang-kurangnya dapat memberikan hasil sama atau melampaui harapan konsumen, sedangkan ketidakpuasan dapat terjadi apabila hasil yang diperoleh tidak memenuhi harapan yang diinginkan konsumen. Terdapat 5 dimensi yang dirancang untuk mengukur kualitas pelayanan yang didasarkan pada perbedaan antara nilai harapan dengan nilai kinerja yang dirasakan oleh konsumen yaitu tangible, reliability, responsiveness, assurance, dan empathy. Lima dimensi tersebut sangat berpengaruh dalam kemajuan suatu perusahaan maka dari itu dengan menggunakan metode data mining dapat ditemukan tren-tren penting bagi perusahaan.Penilaian kepuasan konsumen berdasarkan angket yang telah diisi oleh konsumen. Hasil angket tersebut akan diolah menggunakan algoritma C4.5. Algoritma C4.5 adalah salah satu algoritma dari metode klasifikasi dan menghasilkan sebuah pohon keputusan. Metode pohon keputusan mengubah fakta yang sangat besar menjadi pohon keputusan yang merepresentasikan aturan. Aturan dapat dengan mudah dipahami dengan bahasa alami.Berdasarkan hasil penelitian yang telah dilakukan, penggunaan algoritma C4.5 dapat membantu pihak resto dalam meningkatkan pelayanan sesuai dengan hasil kuisioner yang telah diisi oleh para pelanggan. Berdasarkan hasil perhitungan, pelanggan puas terhadap variabel Tangiables (Fasilitas), Tangiables (Peralatan), Tangiables (Penampilan Karyawan). Sedangkan pelanggan tidak puas terhadap satu variabel yaitu Tangiables (Komunikasi). Nilai gain tertinggi adalah variabel tangiables dengan nilai 0,378118. Sedangkan indikator dari variabel tangiables yang mempunyai nilai entropy tertinggi adalah indikator fasilitas dengan nilai 0,764205. Total kuisioner yang diisi sejumlah 15 kuisioner, 11 orang menyatakan puas dan hanya 4 orang yang menyatakan tidak puas. Kata kunci : Algoritma C4.5, Data Mining, Kepuasan Konsumen
A design method of bilateral control system based on interactive parameters

This paper proposes a method to design bilateral control systems based on interactive parameters. Conventional design methods were based on F parameters and, mainly took care of the elements A and D in F matrix. In this research, all four elements are taken care in order to increase the degree of freedom in system design. A design is based on interactive parameters, Z1, Z2, and θI. The new design method enables an independent design of impedance transmission and scaling. The effect of the proposal is experimentally verified.
Regulons of Three Pseudomonas syringae pv. tomato DC3000 Iron Starvation Sigma Factors

ABSTRACT Pseudomonas syringae pv. tomato DC3000 contains genes for 15 sigma factors. The majority are members of the extracytoplasmic function class of sigma factors, including five that belong to the iron starvation subgroup. In this study, we identified the genes controlled by three iron starvation sigma factors. Their regulons are composed of a small number of genes likely to be involved in iron uptake.
Aerobic physical activity based on fast walking does not alter blood pressure values in non-dipper essential hypertensives.

AIM Walking is a very acceptable form of aerobic exercise. Several trials have demonstrated significant benefits of fast walking on the risk factors of cardiovascular disease, particularly for hypertension. Aim of our study was to assess whether physical activity obtained through fast walking might lead to a different reduction of blood pressure levels in hypertensive patients in relation to different circadian profile of blood pressure. METHODS We have enrolled 84 hypertensive patients, with evidence of stage I hypertension and non-dipper nocturnal profile. All subjects underwent a six weeks physical intervention based on fast walking, three sessions a week. Main outcome measurements were diurnal, nocturnal and 24-h blood pressure levels. RESULTS After the sixth week of physical exercise there was not any significant change in 24-hour mean systolic blood pressure and diastolic blood pressure ABPM values when compared to baseline (respectively 143.2±5.2 vs. 141±4.4 and 91.4±4.8 vs. 90.1±2.5); also no differences in heart rate have been found. CONCLUSION In non-dipper hypertensives a light aerobic program of physical activity based on fast walking seems to be less effective to reduce blood pressure values, contrary to what has been observed in dipper ones.
Complete κ-reducibility of pseudovarieties of the form DRH

We denote by κ the implicit signature that contains the multiplication and the (ω − 1)-power. It is proved that for any completely κ-reducible pseudovariety of groups H, the pseudovariety DRH of all finite semigroups whose regular ℛ-classes are groups in H is completely κ-reducible as well. The converse also holds. The tools used by Almeida, Costa, and Zeitoun for proving that the pseudovariety of all finite ℛ-trivial monoids is completely κ-reducible are adapted for the general setting of a pseudovariety of the form DRH.
Image retrieval with the nonlinear dimension reduction

In this paper we present a new content based image retrieval model. In order to improve the retrieval efficiency and accuracy, variance based color image quantization is presented and color auto-correlogram is constructed based on the quantized image; locally linear embedding is used to reduce the dimensionality of the feature space, it proves to play a critical part in the success of CBIR system. Relevance feedback is designed to bridge the semantic gap between the simplicity of available visual features and the richness of the user semantics. To illustrate the potential of such an approach a prototype image retrieval system has been developed and preliminary experimental results on a database containing about 1000 images demonstrate the effectiveness of the proposed model.
Modelo financiero de portafolios inmobiliarios para los pequeños inversionistas

Los REITs (Real Estate Investment Trust) son un vehiculo a traves del cual se conforma un grupo de inversionistas en un fondo comun para la administracion, inversion y desarrollo de distintos tipos de activos inmobiliarios. Este tipo de negocios crecen por medio la adquisicion de nuevas propiedades mediante deuda apoyada en los ingresos de las propiedades en el cobro del canon de arrendamiento, ademas de la valorizacion de los inmuebles que se adquieren y la valorizacion de sus participaciones en el mercado de valores.
Theophylline for the prevention of radiocontrast nephropathy: a meta-analysis.

BACKGROUND Radiocontrast nephropathy is a common cause of acute renal failure in hospitalized patients. Several studies have examined the capacity of theophylline or aminophylline to prevent radiocontrast nephropathy, with conflicting results. We conducted a meta-analysis of published randomized controlled trials to determine if the pre-procedural administration of theophylline or aminophylline prevents radiocontrast-induced declines in kidney function. METHODS We searched MEDLINE, EMBASE, the Cochrane Collaboration Database, bibliographies of retrieved articles, and consulted with experts to identify relevant studies. Randomized controlled trials of theophylline or aminophylline in hospitalized patients receiving radiocontrast were included. Studies were excluded if they did not report changes in serum creatinine or creatinine clearance within 48 h after radiocontrast exposure. RESULTS Seven randomized controlled trials satisfied all inclusion criteria and were included in the analysis (pooled sample size n = 480). The difference in mean change in serum creatinine was 11.5 micromol/l (95% confidence intervals 5.3-19.4 micromol/l, P = 0.004) lower in the theophylline- or aminophylline-treated groups than controls. One participant (0.6%) required dialysis. CONCLUSIONS Prophylactic administration of theophylline or aminophylline appears to protect against radiocontrast-induced declines in kidney function. Whether these agents reduce the proportion of patients who experience large decrements in serum creatinine concentration, or require dialysis, is unknown.
Game-theoretic medium access control protocol for wireless sensor networks

In the traditional medium access control (MAC) protocols for wireless sensor networks (WSNs), energy consumption is traded for throughput and delay. However, in future WSNs, throughput and delay performance had better not be sacrificed for energy conservation. Here first, an incompletely cooperative game-theoretic heuristic-based constraint optimisation framework is introduced to achieve the goals of throughput, delay and energy conservation simultaneously. Then a simplified game-theoretic MAC (G-MAC) protocol is presented, which can be easily implemented in WSNs. Simulation results show that compared with two typical MAC protocols for WSNs, sensor MAC and timeout MAC, G-MAC can increase system throughput, and decrease delay and packet-loss-rate, while maintaining relatively low energy consumption.
Rapid Chemically Induced Changes of PtdIns(4,5)P2 Gate KCNQ Ion Channels

To resolve the controversy about messengers regulating KCNQ ion channels during phospholipase C–mediated suppression of current, we designed translocatable enzymes that quickly alter the phosphoinositide composition of the plasma membrane after application of a chemical cue. The KCNQ current falls rapidly to zero when phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2 or PI(4,5)P2] is depleted without changing Ca2+, diacylglycerol, or inositol 1,4,5-trisphosphate. Current rises by 30% when PI(4,5)P2 is overproduced and does not change when phosphatidylinositol 3,4,5-trisphosphate is raised. Hence, the depletion of PI(4,5)P2 suffices to suppress current fully, and other second messengers are not needed. Our approach is ideally suited to study biological signaling networks involving membrane phosphoinositides.
Cholesterol and Cancer, in the Balance

Cholesterol metabolites can promote or suppress breast cancer, raising questions about how therapies might disrupt this balance. Mammalian cells synthesize cholesterol through a series of 21 enzymatic steps, generating numerous metabolites that are involved in the control of physiological and developmental processes. Cholesterol itself is the precursor of steroid hormones and sterols, the latter of which can be further modified into molecules that induce specific biological responses. Epidemiological studies have investigated the role of cholesterol in breast cancer risk, with contradictory findings. Recent studies, however, linking cholesterol metabolism to breast cancer may provide some insights. Certain cholesterol metabolites can promote (1, 2) or suppress (3) breast cancer. This raises the important question of how to regulate or inhibit the cholesterol metabolic pathway, and at which steps, in a therapeutic approach to cancer.
Requirements Analysis of a 5 Degree of Freedom Haptic Simulator for Orthopedic Trauma Surgery

There are currently few Virtual Reality simulators for orthopedic trauma surgery. The current simulators provide only a basic recreation of the manual skills involved, focusing instead on the procedural and anatomical knowledge required. One factor limiting simulation of the manual skills is the complexity of adding realistic haptic feedback, particularly torques. This paper investigates the requirements, in terms of forces and workspace (linear and rotational), of a haptic interface to simulate placement of a lag screw in the femoral head, such as for fixation of a fracture in the neck of the femur. To measure these requirements, a study has been conducted involving 5 subjects with experience performing this particular procedure. The results gathered are being used to inform the design of a new haptic simulator for orthopedic trauma surgery.
Analysis of the mechanical properties of wood-plastic composites based on agriculture Chili pepper waste

In this study, a new composite material conception based on polypropylene (PP) and wood particles obtained from agricultural waste was investigated. Specifically, stalks and leafs of chili plants of the region of New Mexico, Texas, USA were used as a plant-based reinforcing material. For this, a design of experiments (DOE) is proposed considering different percentages of PP, wood, fire retardant, coupling agent and UV stabilizer, different mesh sizes are also considered. Samples were obtained using an extrusion molding machine. A statistical analysis is proposed to obtain the optimal percentages of the components considered in the fabrication of the samples in order to enhance the mechanical and morphologic properties of this new composite. Results show that the yield stress, breaking stress and ultimate tensile stress can be maximized with a proportion of 3 to 1 (63,75% PP and 21,25% wood fiber) of PP and wood fiber.
Comparable pharmacokinetics and pharmacodynamics of two epoetin alfa formulations Eporon® and Eprex® following a single subcutaneous administration in healthy male volunteers

Purpose This study aimed to assess and compare the pharmacokinetic (PK) and pharmacodynamic (PD) properties following a single subcutaneous injection of epoetin alfa (Eporon®) with those of the comparator (Eprex®) in healthy male subjects. Subjects and methods A randomized, double-blind, two-sequence, crossover study was conducted. Subjects were randomly assigned to receive a single dose, that is, 4,000 IU, of the test or comparator epoetin alfa. After 4 weeks, all subjects received the alternative formulation. The primary PK parameters, maximum observed concentration (Cmax) and area under the curve extrapolated to infinity (AUCinf), were calculated with the serum erythropoietin (EPO) concentrations from blood samples collected for 144 h after dosing. The reticulocyte, hematocrit, hemoglobin and red blood cell counts were measured up to 312 h as PD markers. The primary PD parameters, maximum observed effect (Emax) and area under the effect curve (AUEC), were obtained from the baseline-corrected reticulocyte count. The serum EPO concentration and the reticulocyte count were used to assess the concentration–response relationship. The tolerability and immunogenicity profiles were assessed together. Results Forty-two subjects completed the study. The mean EPO concentration–time profiles were comparable between the two formulations. The geometric mean ratios (90% CI) of the Cmax and AUCinf were 0.908 (0.843–0.978) and 1.049 (0.999–1.101), respectively, both of which were within the regulatory range of 0.80–1.25. Additionally, the PD and tolerability profiles were similar between the two formulations. The time-matched serum EPO concentration and PD markers presented a counterclockwise hysteresis, suggesting a time delay between the measured concentration and the response. Both formulations were well tolerated, and production of anti-drug antibodies was not observed. Conclusion The two epoetin alfa formulations had similar PK, PD and tolerability profiles. Furthermore, both formulations had a similar time-matched serum EPO concentration and erythropoietic response profile. Thus, the two formulations are expected to be used interchangeably in clinical settings.
Quantification of helix–helix binding affinities in micelles and lipid bilayers

A theoretical approach for estimating association free energies of α‐helices in nonpolar media has been developed. The parameters of energy functions have been derived from ΔΔG values of mutants in water‐soluble proteins and partitioning of organic solutes between water and nonpolar solvents. The proposed approach was verified successfully against three sets of published data: (1) dissociation constants of α‐helical oligomers formed by 27 hydrophobic peptides; (2) stabilities of 22 bacteriorhodopsin mutants, and (3) protein‐ligand binding affinities in aqueous solution. It has been found that coalescence of helices is driven exclusively by van der Waals interactions and H‐bonds, whereas the principal destabilizing contributions are represented by side‐chain conformational entropy and transfer energy of atoms from a detergent or lipid to the protein interior. Electrostatic interactions of α‐helices were relatively weak but important for reproducing the experimental data. Immobilization free energy, which originates from restricting rotational and translational rigid‐body movements of molecules during their association, was found to be less than 1 kcal/mole. The energetics of amino acid substitutions in bacteriorhodopsin was complicated by specific binding of lipid and water molecules to cavities created in certain mutants.
Optical Performance of laser-patterned high-resistivity Silicon Wafer in the frequency range of 0.1-4.7 THz

Direct laser ablation (DLA) is a mask-less technology used for the research and development of optical components of various materials [1]. The relevance of the DLA technology is verified demonstrating the functional optical components including multilevel phase Fresnel lenses on silicon and Soret zone plates developed on a free standing metal-foil [2]. In order to reduce the reflection losses, the anti-reflection structures on a back side of silicon wafer can be patterned by the same DLA technology as this has been proposed recently [3]. In this work we studied optical transmission of laser patterned high resistivity silicon wafers used for development of the diffractive optics in the frequency range of 0.1 – 4.7 THz. The samples were prepared on a 500 µm thick, both-sides polished, high resistivity silicon wafer varying the surrounding environment as well as the DLA parameters in order to modify the composition and roughness of the surface modified. Most of the samples were fabricated in an ambient air, while others were developed in an argon-rich atmosphere at the pressure of 1 atm and 2 atm. Stylus profiler and scanning electron microscope were employed to characterize the samples morphology. Optical performances were studied measuring with a Golay cell detector the transmittance of the THz beam of a quantum cascade laser (QCL) operating at 2.5, 3.1, and 4.7 THz. The dielectric constants dispersion for each sample was also obtained by a THz time domain spectroscopy (TDS). Dependence of transmittance on surface roughness at different THz frequency allowed us to identify the critical value Ra at which the transmittance dropped by 20%. For example data presented in Fig. 1 indicates that the critical Ra value at frequency 4.7 THz is of about 1.9 m. We will discuss a nonlinear dependence of the critical Ra value on the THz radiation frequency. The impact of silicon processing in an oxygen-free environment to the transmittance performance will also be demonstrated and discussed.
Suppression of a Neocortical Potassium Channel Activity by Intracellular Amyloid-β and Its Rescue with Homer1a

It is proposed that intracellular amyloid-β (Aβ), before extracellular plaque formation, triggers cognitive deficits in Alzheimer disease (AD). Here we report how intracellular Aβ affects neuronal properties. This was done by injecting Aβ protein into rat and mouse neocortical pyramidal cells through whole-cell patch pipettes and by using 3xTg AD model mice, in which intracellular Aβ is accumulated innately. In rats, intracellular application of a mixed Aβ1-42 preparation containing both oligomers and monomers, but not a monomeric preparation of Aβ1-40, broadened spike width and augmented Ca2+ influx via voltage-dependent Ca2+ channels in neocortical neurons. Both effects were mimicked and occluded by charybdotoxin, a blocker of large-conductance Ca2+-activated K+ (BK) channels, and blocked by isopimaric acid, a BK channel opener. Surprisingly, augmented Ca2+ influx was caused by elongated spike duration, but not attributable to direct Ca2+ channel modulation by Aβ1-42. The Aβ1-42-induced spike broadening was blocked by electroconvulsive shock (ECS), which we previously showed to facilitate BK channel opening via expression of the scaffold protein Homer1a. In young 3xTg and wild mice, we confirmed spike broadening by Aβ1-42, which was again mimicked and occluded by charybdotoxin and blocked by ECS. In Homer1a knock-out mice, ECS failed to block the Aβ1-42 effect. Single-channel recording on BK channels supported these results. These findings suggest that the suppression of BK channels by intracellular Aβ1-42 is a possible key mechanism for early dysfunction in the AD brain, which may be counteracted by activity-dependent expression of Homer1a.
Improving self-management of people with type 2 diabetes in the first years after diagnosis: Development and pilot of a theory-based interactive group intervention

Objectives: To describe how principles of self-regulation and social support could be integrated in a group intervention to improve self-management of people with type 2 diabetes mellitus in the early phase of illness and to pilot its suitability in a primary care setting. Methods: Principles of the Common-Sense Model of Self-Regulation, Social Cognitive Theory of Self-Regulation and social support theories were integrated in the intervention. Based on this, a three-session group course was developed to challenge illness perceptions of participants that discourage adequate self-management, to practice goal-setting and behavioural actions and to create a supportive environment. The intervention was piloted with persons with early-stage (1–3 years post diagnosis) type 2 diabetes mellitus selected in general practice in the Netherlands. Data about the suitability of the intervention were retrieved by means of observation and audio-recording of the sessions, an evaluation form filled in by the participants and an evaluation meeting with the group leaders. Results: In total, 16 type 2 diabetes mellitus patients participated in the pilot, who were divided into a group of single participants (N = 8) and a group (N = 8) who participated with their partner. Discrepancies between perceptions of one’s own condition and type 2 diabetes mellitus in general were observed. Goal-setting and developing action plans appeared to be difficult tasks for many participants, whereas others felt these exercises were not useful as they did not feel a need to make changes in living with diabetes. The group-based format was appreciated as was the participation of partners. Conclusion: Challenging the illness perceptions of persons with early-stage type 2 diabetes mellitus by a brief interactive group course is feasible and important, as many of these people tend to underestimate the seriousness of their diabetes. However, motivating persons with early-stage type 2 diabetes mellitus to participate in self-management interventions remains a challenge. Offering the intervention as an integral part of type 2 diabetes mellitus management in primary care is desirable.
T-cell recognition of the 18-kilodalton antigen of Mycobacterium leprae

The 18-kilodalton (kDa) antigen of Mycobacterium leprae was expressed as a fusion protein with a 2-kDa leader peptide and used in proliferation assays with peripheral blood cells. Fifty percent of untreated tuberculoid leprosy patients and 93% of long-term leprosy contacts responded to the recombinant protein in lymphocyte transformation tests. Comparison of the stimulation indices in the two groups showed that the contacts responded more strongly than the tuberculoid leprosy patients. Seventy percent of Mycobacterium bovis BCG-vaccinated European donors responded, although with low stimulation indices. The isolation of 18-kDa antigen-responsive T-cell lines from a BCG-vaccinated British donor confirmed that the 18-kDa antigen contains at least one cross-reactive epitope. These results indicate that the 18-kDa protein is an important antigen in the immune response to leprosy.