Miracle-dz/UniFAR-FTUs huggingface dataset:
New COP1‐binding motifs involved in ER retrieval

Coatomer‐mediated sorting of proteins is based on the physical interaction between coatomer (COP1) and targeting motifs found in the cytoplasmic domains of membrane proteins. For example, binding of COP1 to dilysine (KKXX) motifs induces specific retrieval of tagged proteins from the Golgi back to the endoplasmic reticulum (ER). Making use of the two‐hybrid system, we characterized a new sequence (δL) which interacts specifically with the δ‐COP subunit of the COP1 complex. Transfer of δL to the cytoplasmic domain of a reporter membrane protein resulted in its localization in the ER, in yeast and mammalian cells. This was due to continuous retrieval of tagged proteins from the Golgi back to the ER, in a manner similar to the ER retrieval of KKXX‐tagged proteins. Extensive mutagenesis of δL identified an aromatic residue as a critical determinant of the interaction with COP1. Similar COP1‐binding motifs containing an essential aromatic residue were identified in the cytoplasmic domain of an ER‐resident protein, Sec71p, and in an ER retention motif previously characterized in the CD3ϵ chain of the T‐cell receptor. These results emphasize the role of the COP1 complex in retrograde Golgi‐to‐ER transport and highlight its functional similarity with clathrin–adaptor complexes.
The permeability of mammary ducts

1. The permeability of the teat mucosa of the goat has been studied in vitro and, as an isolated teat pouch, in vivo. In vivo the mucosa was found to be impermeable to radioactive Na, K, Cl and Rb isotopes and to labelled lactose, but permeable to 3HOH, and to a lesser extent, urea.
Correlation between adherence to HeLa cells and serogroups, serotypes, and bioserotypes of Escherichia coli

Four hundred fifty Escherichia coli strains of 45 O serogroups and subgroups and 112 serotypes were studied to determine their patterns of adherence to HeLa cells. Adherence was exhibited by strains of 17 O serogroups and subgroups, but within these groups more than one adherence pattern was frequently observed. However, within each serotype, the adherence pattern was highly consistent. Localized adherence (LA) was observed much more frequently in serotypes that we considered to be enteropathogenic E. coli serotypes (93%) than in other serotypes (14%), whereas diffuse adherence (DA) occurred predominantly among nonenteropathogenic E. coli strains. Determination of biochemical characteristics showed that within O serogroups, nonmotile strains tended to have the same behavior as motile strains with the LA adherence pattern, suggesting that they were derived from these motile strains. LA and non-LA strains of the same serotype differed biochemically. LA appears to be a property of most E. coli commonly considered to be enteropathogenic and should assist attempts to determine which E. coli are enteropathogenic and to elucidate their pathogenic mechanisms.
Multiple Intra-Cranial Hemorrhages After Carotid Endarterectomy

ABSTRACT: Intra-cerebral hemorrhage is an unusual and often fatal complication of endarterectomy (CEA). Previous cerebral infarction, intra-operative or post operative hypertension, and the use of anti-coagulants are some of the defined major risk factors. Hemorrhage usually occurs early after CEA, and a second hemorrhage has only once been reported. We wish to report a patient who developed three separate hemorrhages following CEA. This patient had a long history of poorly controlled hypertension. We believe that poorly controlled hypertension, in addition to other reported factors, may be an important separate risk factor for post-CEA hemorrhage.
Jacobi's action and the recovery of time in general relativity.

We argue that the usual action principle of general relativity, applied to spacetimes with closed spatial geometries, should be regarded as analogous to Jacobi's form of the principle of stationary action, in which the energy rather than a physical time is fixed. Following the paradigm of quantization based on Jacobi's action for a nonrelativistic particle, we show that the Wheeler-DeWitt equation corresponds to a time-independent Schr\"odinger equation. The relationship between Jacobi's and Hamilton's action principles then allows us to derive a time-dependent Wheeler-DeWitt equation of the Schr\"odinger type. In this equation, the role of energy is played by the cosmological constant and that of physical time by the four-volume of spacetime.
Application of empirical mode decomposition to ultrasonic signal

In ultrasonic nondestructive testing, the ultrasonic echo-signal of pulse reflection is often disturbed by electronic noise, structure noise and so on. In order to improve signal detection and analysis the ultrasonic defect echo-signal must be denoised. In this paper, a new noise cancellation of empirical mode decomposition is proposed for enhancing signal-to-noise ration of the ultrasonic echo-signal. The ultrasonic echo-signal was collected by experimental system of ultrasonic data acquisition. The signal-to-noise ratio was enhanced about 6db by using this method and it is easy to identify the ultrasonic defect signal. Keywords-Ultrasonic Signal; Denoising; Empirical Mode Decomposition ;
The Role of Spinal Flexibility in Back Pain Complaints within Industry: A Prospective Study

Commonly used clinical measurements of spinal flexibility in the sagittal and frontal planes were examined as predictors of future back pain reports within industry. The study sample consisted of 3,020 aircraft manufacturing employees who were examined and tracked for more than 4 years for reports of back pain. Modified Schober, sitand- reach, and lateral bending measurements were not significantly associated with risk of future back pain reporting, nor were any trends present. There was a statistically significant relationship between decreased flexibility and reports of current or previous back problems. However, the differences in flexibility between subjects with and without a history of back problems were too small to be of practical significance.
The Ratio of Glycated Albumin to HbA1c is Correlated with Diabetes Duration According to Decreases in Insulin Secretion in Patients withAutoimmune Type 1 Diabetes and Type 2 Diabetes

Glycated albumin (GA) is a marker of glycemic control that reflects postprandial plasma glucose levels and glycemic excursions better than HbA1c. However, no reports have examined correlations between diabetes duration and the ratio of glycated albumin to HbA1c (GA/HbA1c ratio) in patients with autoimmune type 1 diabetes (T1AD) or type 2 diabetes (T2D). We conducted a cross-sectional study involving 219 patients with T1AD and 141 patients with T2D. We evaluated correlations between diabetes duration, the GA/HbA1c ratio and fasting serum C-peptide immunoreactivity (CPR), index of insulin secretion capacity. The GA/HbA1c ratio was significantly correlated with diabetes duration in both T1AD and T2D patients (T1AD; R=0.139, p<0.001, T2D; R=0.340, p<0.001). Fasting serum CPR was inversely correlated with diabetes duration (T1AD: R=-0.280, p<0.001; T2D: R=-0.349, p<0.001) as well as the GA/HbA1c ratio (T1AD: R=-0.240, p<0.001; T2D: R=-0.378, p<0.001) in both T1AD and T2D patients. We firstly reported that the GA/HbA1c ratio was positively correlated with diabetes duration in both T1AD and T2D patients. Insulin secretion capacity might influence this relationship.
The role of FoxC1 in early Xenopus development

FoxC1 is an important transcription factor in vertebrate development since its mutation in humans results in Axenfeld‐Rieger syndrome. In the mouse, disturbance of its function causes congenital hydrocephalus and abnormalities in the development of various mesodermal derivatives. In this report, we provide one mechanistic basis for the requirement for FoxC1 in vertebrate development. We find that, in Xenopus laevis embryos, FoxC1 expression is regulated by the maternal T‐box transcription factor VegT, via the nodal sub‐family of TGFβ signaling transducers. We show that at the late neurula to early tailbud stage, FoxC1 depletion causes the down‐regulation of adhesion molecules, EP and E cadherin, as well as members of the Ephrin/EphR signaling families in the mesoderm germ layer resulting in the loss of adhesion and apoptosis of mesodermal cells. Developmental Dynamics 236:2731–2741, 2007. © 2007 Wiley‐Liss, Inc.
A Study on the Relationship between Carotid Artery Intima-Media Thickness and Clinical Chemistry Tests

경동맥 내중막 두께는 뇌혈관질환과 관상동맥질환을 정밀하게 측정하는 검사이다. 많은 선행논문에 따르면 경동맥 내중막 두께는 죽상동맥경화를 예측하고 심혈관질환의 위험인자와 연관성이 높으며, 심근경색이나 뇌졸중 발생 위험을 예측할 수 있는 독립인자로 연구되었다. 따라서 본 연구는 혈액검사 중 임상화학적 검사결과와의 상관관계 연구를 통해 경동맥 내중막 두께와 다른 독립인자를 확보하는 것이 목적이었다. 연구결과 피험자의 부족으로 인해 심혈관계관련 임상화학적 요인과는 상관관계를 입증하지 못했으나, 경동맥 내중막 두께와 ALT (p＜0.05), GGT (p＜0.05), Uric acid (p＜0.05), CEA (p＜0.05)와 양의 상관관계를 통계적인 유의 수준으로 입증하여 지속적인 연구의 문제를 제기하였다.
Memory and Growth in the Superior Temporal Gyri

SUMMARY: The superior temporal gyri were measured in 33 infants and in 33 adults. In the adults, most right superior temporal gyri were larger. This asymmetry was not found in infants, a difference which suggests greater growth of the right superior temporal gyri in the population from which our sample was taken. The asymmetry may be related to the functional asymmetry found by Penfield: some of his patients reported re-experiencing of past sensory experiences with electrical stimulation of the temporal lobe. This response was more frequently evoked from the right hemisphere.
Evaluation of phenotypic similarities between Stargardt flavimaculatus and retinal pigment epithelial pattern dystrophies.

AN INTRAFANIILIAL LINK BETWNTEEN ENTITIES WN'ITHIN THE PArrERiN DYSTROPHY groups",2 as well as b)etween pattern and Best's vitelliform dystrophy3'4 has l)een reported. A histopathologic study of the latter entity5 also reported a similarity of the accumulated lipoprotein to that reported in a histopathologic study of the flecks of fundus flavimaculatus.6 It was therefore subsequently suggested, on the basis of ophthalmoscopic morphology, that the basic defect in the retinal pigment epithelium (RPE) pattern dystrophies may I)e the deposition of an abnormal lipofusciin material in the RPE similar to fundus flavimaculatus.7 In order to determine whether there are objective similarities between Stargardt flavimaculatus (SF) anid the RPE pattern dystrophies, an evaluation was conducted of cases from the Medical College of Wisconsin grouped as RPE patterni dystrophies (Sjogren's reticular dystrophy,8imacroreticular dystroplhy,9 and butterfly dystrophy'0) and Stargardt flavimaculatus (Stargardt's diseasell-15 and fundus flavimaculatusl620)) to determine whetlher similarities exist. The following characteristics were evaluated: expressions of ophthlalmiloscopic morplhology of the RPE opacities, presenice of "dark or silent choroid"21'22 by fluorescein angiography, and the extent of progressive RPE atrophy.
Center-level variation in accuracy of adverse event reporting in a clinical trial for pediatric acute myeloid leukemia: a report from the Children’s Oncology Group

While cure rates for pediatric acute myeloid leukemia (AML) range from 50–60% in Children’s Oncology Group Trials (COG)[1][1],[2][2] and 60%–70% in European cooperative groups,[3][3],[4][4] AML therapy is very intensive and causes substantial treatment-related morbidity. We recently showed
Sleep disturbances and depressive symptoms: an investigation of their longitudinal association in a representative sample of the UK general population

Background It has been argued that sleep disturbances are a risk factor for depression but previous longitudinal studies have had limitations and not addressed alternative explanations. The aim of this study was to examine the longitudinal association between sleep disturbances and depressive symptoms in a nationally representative sample. Method Data from the 18-month follow-up of the UK National Psychiatric Morbidity survey were used (n = 2406). Sleep disturbances, depressive and other psychiatric symptoms (fatigue, concentration problems, irritability, anxiety and pain symptoms) were assessed using the Revised Clinical Interview Schedule (CIS-R). The bidirectional association between symptoms was investigated with logistic regression analyses and path analysis. Results Sleep disturbances and depressive symptoms were correlated with each other cross-sectionally (r = 0.52, p < 0.001). In the longitudinal analysis, sleep disturbances at baseline did not predict depressive symptoms at follow-up [odds ratio (OR) 1.27, 95% confidence interval (CI) 0.51–3.19] and the same was observed for the reciprocal association (OR 0.87, 95% CI 0.56–1.35). In the path analysis, the reciprocal model did not have a better fit compared to the simpler first-order model without cross-lagged paths. The path from sleep disturbances at baseline to depressive symptoms at follow-up had a minimal contribution to the explained variance of the latter (<1%). Conclusions Previous studies may have overestimated the importance of sleep disturbances as an independent risk factor of depression. The strong cross-sectional association is compatible with sleep disturbances being either a prodromal or a residual symptom of depression and this may have implications for recognition and treatment of depression.
Organizational life and political incorporation of two Asian immigrant groups: A case study

Abstract Civil society is the foundation of a healthy democracy but its immigrant element has received little attention. This paper is a case study of immigrant organizations of highly skilled Asian Indians and Chinese immigrants in a suburban town of Edison, New Jersey. I find that civic participation of Asian Indian immigrants spills over into political incorporation while Chinese immigrant organizations remain marginalized. I argue that local processes of racialization are central in explaining differences in political incorporation of immigrants. In the local context, the Chinese are seen as successful but conformist model minorities and Asian Indians as invaders and troublemakers. The racialization of Asian Indians has resulted in more political activity and higher levels of political visibility of their organizations. The results highlight shortcomings of current assimilation theories, which give little space to civic and political incorporation and view human capital in an unqualifiedly positive light.
Effect of two surface sealant agents on surface roughness of a nano-hybrid resin composite

Associate Professor, Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Kingdom of Saudi Arabia Professor, Department of Pediatric Dentistry and Orthodontics, College of Dentistry, King Saud University, Riyadh, Kingdom of Saudi Arabia Lecturer, Department of Pediatric Dentistry and Orthodontics, College of Dentistry, King Saud University Specialist, Pediatric Dentistry Division, Dental Department, Security Forces Hospital Program, Riyadh, Kingdom of Saudi Arabia Dental Intern, College of Dentistry, King Saud University, Riyadh, Kingdom of Saudi Arabia *Corresponding Author’s E-mail: fabdelmegid@ksu.edu. sa The objective of this investigation was to assess the influence of two surface sealant agents on surface roughness of the nano-hybrid resin composite. Thirty cylindrical specimens were prepared from a nanohybrid resin composite (Grandio) after covering with Mylar matrix strip with no finishing or polishing. The specimens were randomly allocated into 3 groups/10 each: Group 1/control/Mylar strip/no surface treatment; group 2 surface sealant (Biscover LV) was applied, and group 3 surface sealant (GCoat Plus) was applied. The surface roughness (Ra) was determined with a stylus profilometer and the topography of representative samples of the control and experimental specimens were evaluated by scanning electron microscopy (SEM). Group 1/control showed the lowest Ra (M±SD) 0.053±0.021. While Ra of group 2 (Biscover LV) and group 3 (G-Coat Plus) were 0.369±0.040 and 0.381±0.047 respectively. There was no statistically significant difference of surface roughness when Biscover LV and G-Coat Plus surface sealants were applied (p>0.05). SEM examination of the surface of all groups showed comparable surface topography. The surface roughness of the nano-hybrid resin composite tested in this study showed lowest Ra value when Mylar strip was used. No significant difference of surface roughness was found when the two surface sealant agents were applied.
Individualised aminoglycoside dosage based on pharmacokinetic analysis is superior to dosage based on physician intuition at achieving target plasma drug concentrations.

1. A prospective randomised trial was conducted to compare aminoglycoside dose prediction based on individually measured pharmacokinetic data, with dosage based on physician intuition. 2. After 2 days of therapy more patients in the pharmacokinetic group had achieved both peak (6-10 mg 1(-1] and trough (1-2 mg 1(-1] target plasma concentrations (P = 0.007), peaks alone (P = 0.01) and troughs alone (P = 0.01). Their mean (s.e. mean) peak concentration was 6.49 +/- 0.39 mg 1(-1) compared with 4.27 +/- 0.52 mg 1(-1) in the control group (P = 0.001), with trough concentrations of 1.44 +/- 0.22 mg 1(-1) and 0.94 +/- 0.21 mg 1(-1) respectively (P = 0.054). 3. After 5 days of therapy, peak and trough concentrations were still significantly higher in the pharmacokinetic group despite empirical dose adjustment (P = 0.01 and P = 0.013 respectively). 4. The mean (s.e. mean) daily dose of aminoglycoside was higher in the computer group (312 +/- 17 mg vs 203 +/- 13 mg, P = 0.001). 5. These findings suggest that dose estimation based on measured pharmacokinetic parameters is superior at achieving target plasma drug concentrations.
Ubiquitous and Secure Certificate Service for Wireless Ad Hoc Network

Wireless ad hoc network is one of the most suitable platforms for providing communication services to support mobile applications in public areas where no fixed communication infrastructure exists. However, due to the open nature of wireless links and lack of security infrastructure in an ad hoc network environment, applications operating on ad hoc network platforms are subjected to non-trivial security challenges. Asymmetric key management, which is widely adopted to be an effective basis for security services in an open network environment, typically plays a crucial role in meeting the security requirements of such applications. In this paper, we propose a secure asymmetric key management scheme, the Ubiquitous and Secure Certificate Service (USCS), which is based on a variant of the Distributed Certificate Authority (DCA) - the Fully Distributed Certificate Authority (FDCA). Similar to FDCA, USCS introduces the presence of 1-hop neighbors which hold shares of DCA's private signature key, and can collaborate to issue certificates, thereby providing asymmetric key management service. Both USCS and FDCA aim to achieve higher availability than the basic DCA scheme; however, USCS is more secure than FDCA in that the former achieves high availability by distributing existing shares to new members, rather than generating new shares as the FDCA scheme does. In order to realise the high availability potential of USCS, a share selection algorithm is also proposed. Experimental results demonstrated that USCS is a more secure approach of the DCA scheme in that it can achieve stronger security than FDCA while attaining high availability similar to that of FDCA. Experiments also showed that USCS incurs only moderate communication overheads.
Interactions between the nervous and immune systems.

Substantial morphologic and functional evidence exists that supports the reciprocal interactions that occur between the nervous and immune systems. The nervous and immune systems have been increasingly found to use a common chemical language in the form of neuropeptides, cytokines, and hormones. Sophisticated immunologic techniques such as the identification and detection of immune cell surface markers enable researchers to determine the origin and activity of diverse cells in the blood and central nervous system. These techniques have elucidated the activity of immune cells in the central nervous system (CNS) that was previously thought to be privileged from immune surveillance in the presence of an intact blood brain barrier. Immune cells in the CNS play a central role in several degenerative diseases such as Alzheimer's disease, Huntington's disease, Multiple sclerosis, AIDS dementia complex, and nerve destruction associated with trauma. Immune cells also play a role in demyelinating peripheral nerve disorders. Cytokines and neuropeptides secreted by peripheral immune cells have profound effects on behavior that is mediated by the CNS. The close integration between immune and nervous system responses is being increasingly recognized in physiologic and pathologic conditions.
Transmit receive chain in LTE

Long Term Evolution (LTE) is the fourth generation of mobile technology which was introduced in the 3GPP release 8. 4G is specifically designed for packet data communication where the emphasis is purely based on high spectral efficiency, low latency, high peak data rates and frequency flexibility. Air interface is the medium that is used for sending and receiving information between the mobile base station and user equipment (UE). The 4G mobile base station i.e. eNodeB (eNB) uses radio frames to transmit information to the UE. This paper discusses about the LTE radio frame to explore its structure and to understand its configuration for specific a UE. In order to understand the LTE frame structure we explore the various downlink channels and signals that are used to allocate physical resources for UE. Later, this paper will show a software simulation about the LTE radio frame that is transmitted by eNB over a channel which is preconfigured in the software.
Visual laser ablation of the prostate: efficacy evaluated by urodynamics and compared to TURP.

OBJECTIVE To determine the efficacy of visual laser ablation of the prostate (VLAP) in comparison to conventional transurethral resection of the prostate (TURP). MATERIAL AND METHODS 133 patients with benign hyperplasia of the prostate (BPH) were treated by VLAP (n = 90) or TURP (n = 43). International prostate symptom score (IPSS), uroflow, residual urine and grade of obstruction determined by pressure flow studies were evaluated before and after treatment. The VLAP was performed by means of a side firing laser fiber under visual control and using a Nd:YAG laser as energy source. RESULTS VLAP could improve IPSS, uroflow and residual urine in all patients. However, the obstruction grade was lowered to normal only in patients with prostates smaller than 50 ml, whereas TURP was able to eliminate the obstruction in all patients. CONCLUSION VLAP can be offered as an alternative to TURP in patients with BPH as long as the prostate volume is not bigger than 50 ml.
A bibliometric study of Nieuwenhuysen's bibliography of microcomputer software for online information and documentation work

We study a bibliography of documents on a new topic, namely microcomputer software for online information and documentation work. A general Lotka function is fitted to the frequency form of the distribution of items in this bibliogra phy. Data are also described by a truncated Leimkuhler curve; behind the truncation point the so-called Groos droop begins. We show that such droops cannot be explained as the result of a relatively high scattering, due to the recentness of the topic.