Miracle-dz/UniFAR-FTUs huggingface dataset:
PPARs in RhythmicMetabolic Regulation and Implications in Health and Disease

The circadian rhythm, controlled by a complex network of cellular transcription factors, orchestrates behavior and physiology in the vast majority of animals. The circadian system is comprised of a master clock located in central nervous system with 24-hour rotation and periphery clocks to ensure optimal timing of physiology in peripheral tissues. Circadian expression of peroxisome proliferator-activated receptors (PPARs), members of the nuclear receptor superfamily and key mediators of energy homeostasis and metabolism, is regulated by clock genes. PPARs serve as sensors of nutrient and energy/metabolism status to temporally entrain peripheral clock. Metabolism and circadian clocks are tightly intertwined: clock genes drive metabolism, and various metabolic parameters affect clock genes, producing a reciprocal feedback relationship. Due to PPARs’ robust relationship with energy status and metabolism, the aberration of PPARs in the biological clock system leads to abnormal expression of genes in metabolic pathways, thus, contributing to etiology of metabolic syndrome. Studying PPARs’ functions under the context of the mammalian circadian system could advance our understanding of how energy and metabolic status are maintained in the body, which may ultimately lead to rhythmic medical treatment against metabolic syndrome.
Virtual Reality Exposure Therapy for Posttraumatic Stress Disorder of bank employees : A case study with the virtual bank

Este é um artigo de acesso aberto, licenciado por Creative Commons Atribuição 4.0 Internacional (CC BY 4.0), sendo permitidas reprodução, adaptação e distribuição desde que o autor e a fonte originais sejam creditados. Abstract. Exposure Therapy (ET) is an established treatment for Posttraumatic Stress Disorder (PTSD), in which patients gradually confront trauma memories through mental imagery. Virtual Reality Exposure (VRE) is an alternative for those who have difficulties in recreating such memories. Most studies develop VRE scenarios of war or accidents; however, traumatic events in Brazil are mainly of urban violence. Objective: To evaluate the quality of the Virtual Bank scenario through a pilot case study of a banker with PTSD through a cognitive behavioral therapy protocol. Method: A 39-year-old bank employee diagnosed with PTSD through the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) took part on a Cognitive Behavioral Therapy (CBT) protocol including VRE. Patient’s symptoms were assessed through Beck’s anxiety and depression inventories, the Screen for Posttraumatic Stress Symptoms and Posttraumatic Cognitions Inventory. The therapy protocol was comprised of 16 sessions divided into three blocks: (i) psychoeducation; (ii) exposure and (iii) cognitive restructuring and relapse prevention. Reassessments were conducted at the end of each block. The sense of presence in the Virtual Bank was assessed through the Presence Questionnaire (PQ). Results: The patient presented at least 60% of reduction on all instruments and no longer met criteria for PTSD at posttreatment. The greatest reduction on PTSD symptoms scores occurred after the VRE block (-44.8%). The mean score of the PQ was 5.24. Conclusion: CBT protocol with VRE was effective in reducing all measures in this case study. Quality evaluation of the Virtual Bank was positive. Results are promising and similar to those of other innovative case studies using VRE for PTSD.
STABLE ISOTOPIC COMPOSITION OF PORE WATERS AND CALCITE VEINS 1

The oxygen isotopic composition of the pore waters from the sediments and the oxygen and carbon isotopic composition of carbonate veins from basalts of Leg 121 were analyzed. The pore-water data document the extent of the alteration of volcanic ashes and basalt. The influence of an increase in the isotopic composition of deep water as a result of the growth of polar ice caps over the last million years can also be detected in the pore waters of the upper 100 m of the sediments. Temperatures of formation of carbonate veins from basalts from sites located on the Ninetyeast Ridge increase northward along the ridge along with the increased age of the crust and depth of sediments. The temperatures calculated for carbonate veins from Site 758 indicate that a thermal event occurred at some time in the past.
Cloud scavenging of anthropogenic refractory particles at a mountain site in North China

Reply to Referee#1: 1. Overall, the article investigated cloud residual and interstitial particles and addressed the potential impact of aerosol particles on environment (including human health) and climate over one of China’s heavily polluted regions. The study (or campaign) was carried out in a mountain site 1500 m a.g. l. by in-situ sampling followed by lab analysis employing TEM-EDS. The research gained some valuable data to unveil some of the chemical properties and mixing states of cloud residual and interstitial particles in a uniquely polluted area. The underlying logic is sound and the structure of the article is appropriate. The figures are clear and appropriate. However, there is room for grammar improvement and concept clarification. Response: We thank the referee#1’ critical comments. All the comments and concerns raised by the referee have been explicitly considered and incorporated into the revised manuscript.
Investigating user continuance intention toward library self-service technology

Purpose The purpose of this paper is to apply expectation-confirmation theory (ECT) and the unified theory of acceptance and use of technology (UTAUT) to identify potential determinants of library patrons’ intention to continue using (continuance) self-issue and return systems for borrowing and returning books. The role of continuance is specifically interesting and is well-established in the literature of information systems (ISs) and marketing because continuance is considered to be the central element for the survival of ISs and of self-service technology (SST). However, the role of continuance has been neglected by researchers studying library SST adoption. Design/methodology/approach A research model integrating the expectation-confirmation model of IS continuance with UTAUT was developed and empirically validated using data obtained from a field survey involving 128 active users of a self-issue and return system at a public library in Taiwan. Findings Library patrons’ continuance intention was affected by their post-adoption expectation of perceived performance, effort performance and facilitating conditions as well as their satisfaction when using self-issue and return systems. Moreover, a patron satisfaction level was influenced by performance expectancy and confirmation of initial expectations, whereas confirmation had a positive effect on all post-adoption expectations. Originality/value This study broadens perspectives on SST adoption behavior in the library context by identifying some factors that influence library patrons’ continuance decisions. Furthermore, the authors verified the applicability and predictability of the theoretical integration of ECT with UTAUT in a diverse setting because the authors sought survey participants outside of the college population.
Fuzzy Logic Approach for Detecting Black HoleAttack in Hybrid Wireless Mesh Network

Security is one of the main issues in WMN and this network is exposed to various attacks, black hole is one of the possible attacks. The black hole attack is a type of denialof- service attack which passed out disrupts the service of network layer. In our project, we have proposed on fuzzy logic scheme to detect black hole attack and improve the performance of AODV in the parameters like end to end delay, packet delivery ratio. Fuzzy is a mathematical logic that attempts to solve problems by assigning values to an imprecise spectrum of data in order to reach the most accurate conclusion possible.
MODELING GRAIN AND STRAW YIELDS OF WHEAT USING BACK PROPAGATION . pdf

The first objective of this study was to model the effect of yield components, number of grain/spike, number of spikes/m 2 , and 1000 kernels weight on the grain yield and straw yield of wheat. An artificial neural network (ANN), multilayer perceptron feed forward neural network (MLP) was used for developing the predictive model. Two different training algorithms: back propagation (BP) and genetic algorithm (GA) were used to train the MLP which structured of three neurons in the input layer, one hidden layer of six neurons, and two neurons in the output layer. The second objective of the current study was to compare the performance of the aforementioned training algorithms with regard to its ability of prediction as well as to multiple linear regression model (MLR). The MLP was trained with those training algorithms using experimental data as a training set. The deviation of the Root Mean Squared Error (RMSE) between the output and the target values of test set was used as a criterion to stop the training. The precision of the predictive ability of BP was significantly higher than both GA and MLR; also, the convergence speed of BP was higher than GA.
Modeling based on Louvain method in Online Social Networks

Online Social Networks (OSNs) are the most used media nowadays, such as Twitter. The OSNs provide valuable information to marketing and competitiveness based on users posts and opinions stored inside huge volume of data from several themes, topics and subjects. In order to mining the topics discussed on an OSN we present a novel application of Louvain method for Topic Modeling based on communities detection in graphs by modularity. The proposed approach succeeded in finding topics in five different datasets composed of textual content from Twitter and Youtube. Another important contribution achieved was about the presence of texts posted by spammers. In this case, a particular behavior observed by graph architecture (density and degree) allows the classification of a topic as natural or artificial, this last created by the spammers on OSNs.
vonWillebrand Factor and Oxidative Stress Parameters in Acute Coronary Syndromes

Considering the role of von Willebrand factor (vWf) in hemostasis, and the role of oxidative stress in the development of endothelial dysfunction and atherosclerotic disease, the aim of our study was to investigate the relationship between vWf, parameters of oxidative stress and different types of acute coronary syndromes (ACS). Levels of vWf activity (vWfAct), vWf antigen (vWfAg), nitric oxide (estimated through nitrites–NO2 −), superoxide anion radical (O2 −), hydrogen peroxide (H2O2), index of lipid peroxidation (estimated through thiobarbituric acid reactive substances–TBARS), superoxide dismutase (SOD) and catalase (CAT) activity of 115 patients were compared with those of 40 healthy controls. ACS patients had significantly higher vWfAct and vWfAg levels, as well as TBARS levels, while their levels of NO2 −, H2O2, SOD and CAT activities were lower than controls’. vWfAg showed high specificity and sensitivity as a test to reveal healthy or diseased subjects. Multivariant logistic regression marked only vWfAg and TBARS as parameters that were under independent effect of ACS type. The results of our study support the implementation of vWf in clinical rutine and into therapeutic targets, and suggest that ACS patients are in need of antioxidant supplementation to improve their impaired antioxidant defence.
18 Genotoxicity Testing in Pesticide Safety Evaluation

Genotoxicity is a recently developed branch of toxicology, which deals with the study of deleterious effects of toxic agents present in the environment on the structure and function of DNA. Direct damage to DNA is an increasingly more essential focus on ecotoxicology research for two reasons; firstly, because of the far reaching effects of genotoxins on the health of an organism and the possible future implications if the germline is affected, and secondly, because extremely sensitive methods of detecting DNA damage have been developed, which allowed the improvement of early biomarkers for xenobiotic exposure. Genotoxicity can result in three types of genetic lesions. Firstly, single-gene mutations, also called point mutations, which include alterations in the nucleotide sequence of DNA, and may involve either the base substitution or frame – shift mutations. Second are the structural chromosomal mutations or genomic mutations which include changes in chromosomal structure, such as breaking of chromosome, or translocation of an arm, commonly called clastogenensis. Third are numerical changes in the genome; aneuploidy and/or polyploidy (Cajaraville et al., 2003). Induction of DNA damage is one of the primary events in the initiation of carcinogenesis by chemicals. Several chemical pollutants can produce carcinogenic effects through the induction of genetic lesions. Carcinogens can be divided into two categories; genotoxic and epigenetic. Compounds that react directly or indirectly with DNA are, in most cases genotoxic carcinogens for example; polycyclic aromatic compounds, hydrocarbons, heavy metals, alkylating agents etc. are called as genotoxic compounds. Epigenetic carcinogens such as pesticides, asbestos, silica, immunosupressors etc. cause carcinogenesis by inducing a multitude of mechanisms that ultimately bring changes in the DNA of the organism (Cajaraville et al., 2003). Tests for genotoxicity include systems which give an indication of damage to DNA. End points determined are unscheduled DNA synthesis (UDS), sister-chromatid exchange (SCE), single cell gel electrophoresis (SCGE), formation of DNA adducts and mitotic
Surveillance of circulatingstrains in Europe during 1998-2015

One reason for increased pertussis incidence is the adaptation of Bordetella pertussis to 57 vaccine-induced immunity by modulating its genomic structure. This study, EUpert IV, 58 includes 265 isolates collected from nine European countries during 2012 to 2015 (n=265) 59 and compares the results to previous EUpert I-III studies (1998-2009). The analyses included 60 genotyping, serotyping and pulsed-field gel electrophoresis (PFGE) and multi-locus variable- 61 number tandem repeat analysis (MLVA). Genotyping results showed only small variation 62 among the common virulence genes of B. pertussis . Frequencies of serotypes Fim2 and Fim3 63 varied among the four collections. Genomic analyses showed that MLVA type 27 increased 64 to 80% between the periods of 1998-2001 and 2012-2015. Two PFGE profiles, BpSR3 65 (29.4%) and BpSR10 (27.2%), constituted more than 50% of the circulating isolates in the 66 present collection. Our study indicates that the European B. pertussis population is changing 67 more homogenous after the introduction of acellular pertussis vaccines. 68 69 70 71
AC 2012-5457: DEVELOPMENT OF A MECHATRONICS AND INTELLI-GENT SYSTEMS LABORATORY FOR TEACHING AND RESEARCH

His expertise and research interests include broad areas of system dynamics and control, robotics, mechatronics, intelligent systems, advanced signal processing, prognostics and health management, and applications of computational intelligence in engineering and biomedicine. Samanta has developed and taught numerous courses in these areas and supervised students at both undergraduate and graduate levels. He has more than 100 refereed research articles published by professional bodies like ASME, IMechE, AIAA, and IEEE. The papers are regularly cited by independent researchers in their publications (more than 1,200 citations). He is a senior member of IEEE.
alcium influx kinetics , and the features of potassium channels of eripheral lymphocytes in primary Sjögren ’ s syndrome

Objective: The transient increase of the cytoplasmic free calcium level plays a key role in the process of lymphocyte activation. Kv1.3 and IKCa1 potassium channels are important regulators of the maintenance of calcium influx and present a possible target for selective immunomodulation. Design: Case–control study. Subjects and methods: We took peripheral blood samples from 8 healthy individuals and 15 primary Sjögren’s syndrome (pSS) patients. We evaluated calcium influx kinetics following activation in peripheral T lymphocytes. We also assessed the sensitivity of T lymphocytes to specific inhibition of the Kv1.3 and IKCa1 potassium channels, and the Kv1.3 channel expression. Results: The basal cytoplasmatic calcium levels were lower in both Th1 and Th2 lymphocytes in pSS compared to controls. The peak of calcium influx in lymphocytes isolated from pSS patients is reached later, indicating that they respond more slowly to stimulation compared to controls. In healthy individuals, the inhibition of the IKCa1 channel decreased calcium influx in Th2 and CD4 cells to a lower extent than in Th1 and CD8 cells. On the contrary, the inhibition of Kv1.3 channels resulted in a larger decrease of calcium entry in Th2 and CD4 than in Th1 and CD8 cells. In the pSS group, neither of the inhibitors induced alteration in calcium influx. Expression of Kv1.3 channels on CD4, Th2 and CD8 lymphocytes in pSS was significantly higher compared to controls. Conclusion: The altered expression and specific inhibition of potassium channels seem to be related to altered calcium influx kinetics in pSS which distinguish pSS either from healthy controls or other systemic autoimmune diseases. © 2016 Elsevier GmbH. All rights reserved.
Study 1 : Testing the Effect of Customer Demotion on Loyalty Intentions with a Laboratory Experiment

Hierarchical loyalty programs award elevated customer status (e.g., “elite membership”) to consumers who meet a predefined spending level. However, if a customer subsequently falls short of the required spending level, firms commonly revoke that status. The authors investigate the impact of such customer demotion on loyalty intentions toward the firm. Building on prospect theory and emotions theory, the authors hypothesize that changes in customer status have an asymmetric negative effect, such that the negative impact of customer demotion is stronger than the positive impact of status increases. An experimental scenario study provides evidence that loyalty intentions are indeed lower for demoted customers than for those who have never been awarded a preferred status, meaning that hierarchical loyalty programs can drive otherwise loyal customers away from a firm. A field study using proprietary sales data from a different industry context demonstrates the robustness of the negative impact of customer demotion. The authors test the extent to which design variables of hierarchical loyalty programs may attenuate the negative consequences of status demotions with a second experimental scenario study and present an analytical model that links status demotion to customer equity to aid managerial decision making.
The Effects of Ion Implantation Technique on Dental Implant Materials for in-vitro Cell Attachment

Achivement of a dental implant treatment depend on also surface properties of implant material as well as surgical method, implant material and implant desing, Studies have shown that ion implantation is a good candidate for modifying of dental implant surface. _In this thesis, it was observed the effects on osteoblast attachment on modified surfaces with metal+gas hybrid ion implantation by using MEVVA ion implantation technology. For this aim, the material for ion implantation was chosen as titanium (ISO 5832-2 Grade 4) which is the most common material used in dentistry. Zirconium element known as biocompatible and oxygen to increase the passivation of titanium surfaces were used for creating ions simultaneously. _ Attachment of osteoblast on samples was investigated in vitro for comparing the effects of the rougnesses and ion implantation surface modification on attachment of osteoblast. It is observed at the end of the in vitro osteoblast cell attachment is better on rough and ion implanted surfaces.
Response to reviewer comments on ” Is there bimodality of the SAH at 100 hPa ”

The South Asian High (SAH) is an important component of the summer monsoon system in Asia. In this study we investigate the location and drivers of the SAH at 100 hPa during the boreal summers of 1979 to 2014 on interannual, seasonal and synoptic time scales using six reanalyses . Special focus lies :::: seven ::::::::: reanalyses :::: and ::::::::::: observational ::::: data. :::: Our :::::::::: comparison :: of ::: the ::::::: different ::::::::: reanalyses ::::::::: especially :::::: focuses : on the bimodality of the SAH, i.e. the two preferred modes of the SAH centre location: the Iranian Plateau to the west and the Tibetan Plateau to the east. We find that only the National Centers for Environ5 mental Prediction National Center of Atmospheric Research (NCEP/NCAR) reanalysis shows a clear bimodal structure of the SAH centre distribution with respect to daily and pentad (5-day mean) data. Furthermore, the distribution of the SAH centre location is highly variable from year-to-year. As in simple model studies, which connect the SAH to heating in the tropics, we find that the mean seasonal cycle of the SAH and its centre are dominated by the expansion of convection in the South Asian region (70° E – 130 ::::: E–130° E x 15° N – 30 ::::: N–30° N) on the southeastern border of the SAH. A composite analysis of precipi10 tation and OLR ::::::: outgoing :::::::: longwave :::::::: radiation data with respect to the location of the SAH centre reveals that a more westward (eastward) location of the SAH is related to stronger (weaker) convection and rainfall over India and stronger (weaker :::::: weaker ::::::: (stronger) precipitation over the West Pacific.
SOĞUK SAVAŞ SONRASINDA YENİ GÜVENLİK ÜZERİNE KURAMSAL TARTIŞMALAR (THEORETICAL DEBATES ON NEW SECURITY IN THE AFTERMATH OF THE COLD WAR)

This study aims at analysing the key theoretical debates on new security in International Relations (IR) in the aftermath of the Cold War. Firstly, it starts examining the major theoretical approaches on the new concept of security. It provides a critical reflection on security issues premised upon the view that the wide range of the levels, referents, and dimensions not only reflects an engagement in ‘a continuing process of historical change’, but also it reflects a normative element of a possible transformation within the prevailing order. Secondly, it attempts to demonstrate how the traditional conception of security has dramatically changed both in its levels and dimensions of investigation after the end of the Cold War. Particulary, the redefinition of security is examined through a Critical Security Studies (CSS) perspective combined with Social Constructivism. In sum, this study examines how the concept of security has redefined within the discipline of IR in the beginning of the post-Cold War era.
Kooperacija i konsolidacija tokova u city logistici

Logistički sistemi urbanih sredina intenzivno se menjaju i prilagođavaju zahtevima efikasnijeg snabdevanja i očuvanja životne sredine. Od efikasnosti logističkog sistema zavisi produktivnost i profitabilnost kompanija, ali i zadovoljenje zahteva stanovnika grada u smislu dostupnosti različitih roba po nižim cenama. Sa druge strane, nivo interesovanja za okruženje sve više raste i inicira istraživanja i primenu efikasnih i održivih inicijativa, koncepcija city logistike. Najčešće primenjivane inicijative su one koje se odnose na regulative, odnosno ograničenja i kontrolu pristupa dostavnih vozila. Međutim, ove inicijative ne rešavaju probleme realizacije robnih tokova i mogu pogoršati logističke performanse. Osim toga, nisu se pokazale efikasnim sa aspekta okruženja i ekonomije. Iz ovog razloga, promovišu se koncepcije koje podrazumevaju kooperaciju prevoznika i konsolidaciju tokova. One su fokusirane na logističke aktivnosti i mogu dati brojne pozitivne efekte u cilju ekološke i ekonomske održivosti. Ipak, retko su zaživele u praksi, a većina je bila jedva uspešna. Pomenute činjenice ukazuju na značaj istraživanja ovih koncepcija, kako sa aspekta strukture i karakteristika logističkog sistema, tako i sa aspekta uloge i funkcije javnog sektora u njihovoj promociji. Ključne reči: city logistika, kooperacija, konsolidacija, modeli, efekti, problemi