Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimization in Wire Electric Discharge Machining of Nickel-Titanium Shape Memory Alloy

The present study focuses on optimizing the process parameters during machining of NiTi (Nickel-Titanium) shape memory alloy by wire electric discharge machining (Wire EDM) for simultaneously maximizing material removal rate and minimizing tool wear rate u sing brass wire as electrode. Taguchi’s design with utility and modified utility optimization techniques have been used for simultaneous multi-response optimization. Different analyses were performed to determine the optimal settings in both utility and mo dified utility concepts. The optimal results of both methods disclose that the pulse on time of 115µsec and pulse off time of 40µsec with spark gap set voltage of 20V are useful for maximizing material removal rate and minimizing tool wear rate. The optimization results indicate that the spark gap set voltage is the majority significant parameter that affects the tool wear rate and material removal rate.
The importance of temperature on Henry's‐law solubility constants: Removing trihalomethanes by aeration

Many small drinking water systems have faced, or are facing, difficulties in meeting U.S. Safe Drinking Water Act regulations. Aeration is a technology that could be effective in helping small systems meet trihalomethane standards, but its effectiveness is based on Henry's law. Henry's law governs the relationship between the concentration of a volatile organic chemical in liquid and the gas' vapor pressure over that liquid. The higher the Henry's‐law constant, the more readily the compound can be transferred from water to air. Henry's‐law constant is independent of flow rate but, as discussed in this article, is a function of temperature. This article provides information on the relationship of temperature to the value of Henry's‐law constants with the goal of assisting water system managers and operators in optimizing aeration for removing disinfection byproducts.
Confirmation of Safety, Efficacy and Response Duration in Non-Hodgkin Lymphoma Patients Treated with 60 μg/m2/d of BiTE® Antibody Blinatumomab.

Abstract 2723 Poster Board II-699 Indolent and mantle cell lymphoma (MCL) are predominantly treated with chemotherapy or a combination of chemotherapy with monoclonal antibodies. Despite high initial response rates, eventually almost all patients however relapse, leaving the disease incurable. Moreover, with increasing numbers of regimens administered, the responsiveness of patients is reduced. Blinatumomab is a single-chain bispecific antibody construct with specificity for CD19 and CD3, belonging to the class of bispecific T cell engager (BiTE®). Here, we report on patients in an ongoing phase 1 trial treated at a dose of 60 μg/m2/d for 4–8-week by continuous i.v. infusion with single-agent blinatumomab. In total, 12 patients with indolent mainly follicular lymphoma or MCL were treated at 60 μg/m2/d during the first treatment cycle. 11/12 patients showed an objective response (7 PR and 4 CR). As of July 2009, median response duration was 12 months with 6 out of 11 responses still ongoing. The single non-responding patient experienced a reversible, neurological adverse event leading to early discontinuation of treatment. Of the 11 responders, one patient developed a port infection and 4 patients showed neurological symptoms, which were all fully reversible. In order to mitigate neurological adverse events during first dosing, which can occur in a defined subset of patients, patients were treated for 1–2 weeks with a lower initial dose (5 and/or 15 μg/m2/d) followed by a maintenance dose of 60 μg/m2/d. A lower starting dose appeared to ameliorate initial adverse events to an extent that treatment could be continued without interruption. Taken together, our data confirm a high single-agent activity of 60 μg/m2/d blinatumomab infused for 4–8 week with long lasting remissions and a favorable risk/benefit profile. The confirmed dose will be considered for further clinical development of blinatumomab in follicular lymphoma and MCL. New data on patients treated with a dose of 90 μg/m2/d will be presented. Disclosures: Nagorsen:Micromet: Employment, Equity Ownership. Zugmaier:Micromet: Employment, Equity Ownership. Schmidt:Micromet: Employment, Equity Ownership. Klappers:Micromet: Employment, Equity Ownership. Baeuerle:Micromet: Employment, Equity Ownership. Kufer:Micromet: Employment, Equity Ownership, Patents & Royalties. Bargou:Micromet: Consultancy, Patents & Royalties.
Assessment of Nutritional Status and Cognitive Development of Preschool Children at Minia Governorate, Egypt

Objective: This study aimed to assess the magnitude of malnutrition among pre-school children in Minia district, and its impact on their cognitive performance. Subjects and Methods: This is a cross sectional community based study that was carried among preschool children in El-Minia district. Preschoolers were recruited from randomly selected public schools with a kindergarten from various rural and urban areas. The sample size was 288 children age ranged between 4 years (48 months) to below 7 years (83 months). Data were collected by an aided questionnaire which included socio demographic, dietary pattern and food frequency. The nutritional status was assessed by anthropometric measurements. The Stanford-Binet Intelligence Test, Arabic edition 4 (SBITA) was used to measure the intelligence quotient (IQ). Results: 288 children were studied, (18.8%) of children are overweight, (7.6%) are obese, and only (2.1%) are wasted; according to BMI-for-age Zscore, (28.8%) are at risk of stunting and only (9.4%) are stunted according to Height-for-age Z-score. IQ score was significantly higher among children from urban region (93.6±6.1), children whose fathers, mothers education is university and above (93.9±6.4), (94.2±6.6) respectively, children whose mothers occupation is professional work (94.2±6.4), Mean IQ score was significantly lower among children whose mothers use margarine in cooking (90.8±5.9), while the mean I.Q. score was significantly higher in those who take supplementary vitamins and minerals regularly (98.3±6.6). Conclusion: Proper environmental condition (including proper nutrition, parent’s education and socio-economic standards) were crucial for cognitive and intellectual development of the studied preschool children. It is important to intervene early by nutrition education message to mothers about healthy feeding practices.
Knowledge, attitude and practices regarding complementary feeding among mothers of children 6 to 24 months of age in Konaseema region

Background: Complementary feeding is the introduction of semisolid or solid food in infant who is on breast feeding, when mother’s milk is no longer enough to meet the nutritional needs. Understanding the social beliefs, knowledge, attitude and practices about complementary feeding among mothers is an important step prior to designing an intervention strategy to prevent malnutrition in children. Aim of the study was to assess the knowledge, attitude and practices regarding complementary feeding among mothers and its effect on growth of the child. Methods: Prospective study including 500 mothers with children between 6 to 24 months of age in KIMS, from December 2014 to November 2015. Results: Mean age of knowledge regarding complementary feeding in mothers was 8.01 months. Most of the mothers 307/500 (61.4%) started complementary feeding because of insufficient milk, 183/500 (36.6%) mothers started complementary feeding as they felt the child required more milk, 30/500 (6%) mothers started complementary feeding as the child was sick and not drinking milk. There is significant positive correlation between age of complementary feeding and malnutrition in first 2 years of life. Conclusions: Mother’s knowledge regarding timing of complementary feeding is inadequate and practices are inappropriate. Majority of them are not aware of the current recommendations. It is essential to give accurate information and education about complementary feeding to prevent malnutrition and improve the health status of children.
Challenges of community-based tourism in Botswana: a review of literature

This paper provides a review of literature and synthesis of community-based tourism in Botswana by examining the issues associated with its conception, design and implementation. The paper is principally guided by the concept of sustainable tourism development. Results indicate that the concept of community-based tourism in Botswana can be traced to the commencement of Community-Based Natural Resource Management (CBNRM), which has its successes and challenges. The paper’s findings show the following challenges: community definition problems; multi-stakeholder participation, diversity and heterogeneity; deficiency in business acumen; lack of income distribution plans and reinvestment priorities and passive community participation. In view of the above, the future might be more challenging for the realisation of sustainable community-based tourism (CBT). The paper concludes with recommendations that may assist in improving the organisation, structure and implementation of community-based tourism in Botswana to ensure sustainability in community-based tourism development.
Global weak solutions to a Vlasov‐Fokker‐Planck/compressible non‐Newtonian fluid system of equations

This article is devoted to a coupled microscopic/macroscopic model describing the evolution of particles dispersed in a fluid. The system consists in a Vlasov‐Fokker‐Planck equation to describe the microscopic motion of the particles coupled to the equations for a compressible non‐Newtonian fluid. An initial‐boundary value problem is studied in a bounded domain with the divergence of the velocity field keeping bounded. The existence of global weak solution is established through an approximation scheme, a fixed point argument, the lower semi‐continuity of monotone operators, energy estimates and the principle of compensated compactness.
The estimation of heritability and repeatability of first service conception and first cycle calving in Angus cattle

© The Author(s) 2019. Published by Oxford University Press on behalf of the American Society of Animal Science. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Transl. Anim. Sci. 2019.3:1646–1649 doi: 10.1093/tas/txz047
The New Method Using Shannon Entropy to Decide the Power Exponents on JMAK Equation

The JMAK (Johnson–Mehl–Avrami–Kolmogorov) equation is exponential equation inserted power-law behavior on the parameter, and is widely utilized to describe the relaxation process, the nucleation process, the deformation of materials and so on. Theoretically the power exponent is occasionally associated with the geometrical factor of the nucleus, which gives the integral power exponent. However, non-integral power exponents occasionally appear and they are sometimes considered as phenomenological in the experiment. On the other hand, the power exponent decides the distribution of step time when the equation is considered as the superposition of the step function. This work intends to extend the interpretation of the power exponent by the new method associating Shannon entropy of distribution of step time with the method of Lagrange multiplier in which cumulants or moments obtained from the distribution function are preserved. This method intends to decide the distribution of step time through the power exponent, in which certain statistical values are fixed. The Shannon entropy to which the second cumulant is introduced gives fractional power exponents that reveal the symmetrical distribution function that can be compared with the experimental results. Various power exponents in which another statistical value is fixed are discussed with physical interpretation. This work gives new insight into the JMAK function and the method of Shannon entropy in general.
Phytocosmetics in Africa

The demand for cosmetics from natural sources is increasing. It is attractive to the consumer market due to their functional benefits. The phytocosmetics market of toiletries, perfumes and cosmetics has grown in the world market. This article aims to focus on and examine the state of phytocosmetics in Africa (Fig. 1). A survey from United States showed growth in the use of herbs by adults for cosmetics use and for the treatment of medical conditions, at a rate of 3% – 12% – 21% in the years 1990 – 1997 – 2001 respectively.1 It was reported 2 that 38 million people from US used herbal therapies. Development of cosmetics from Africa, from seed oils and their components, are attracting international companies with their marketing potential. The African beauty market is expected to double in the next decade with the rate of sales increasing up to a rate of 5 – 10 % of beauty care products. In Africa the per capita spending on cosmetics ranges from 10 – 20 times lower than in developed market, but Africans can look forward to a resurgence of phytocosmetic products and an increase of marketers who are interested in their
Comprehensive Conception of High Step-Up DC–DC Converters With Coupled Inductor and Voltage Multipliers Techniques

Due to the plethora of non-isolated high gain step-up dc-dc converters presented in the literature, it has become important to comprehensively review and classify them, as well as to derive methods to generalize the usage of the commonly employed techniques. Motivated by this need, this paper not only proposes a new family of high gain step up dc-dc converter, but a generalized methodology to derive them from any classical dc-dc topology by applying a coupled inductor and voltage multiplier cells. For illustrating the methodology, high gain dc-dc converters based on the basic topologies (Buck, Boost, and Buck-Boost) are developed and analyzed. These converters are compared in terms of voltage gain, coupled inductor size, voltage stresses, total device rating, switching frequency effect in power loss, and output power regulation. Moreover, in order to verify the proposal, two practical experimentations are accomplished. Firstly, a prototype able to operate as any of the three basic topologies with different gain cells is developed for comparing theoretical, simulated, and experimental static gain results. Secondly, well-designed prototypes concerning to the Buck-, Boost-, and Buck-Boost-based converters are assembled for efficiency evaluation.
Anticonvulsant Step Therapy Criteria with Medical Diagnoses Option

Brand Generic Dosage Forms Keppra levetiracetam tablets , oral solution, injection Keppra XR levetiracetam extended-release tablets Lamictal lamotrigine tablets , chewable dispersible tablets , starter kits Lamictal ODT lamotrigine orally disintegrating tablets Lamictal XR lamotrigine extended-release tablets Lyrica pregabalin capsules Topamax topiramate tablets , sprinkle capsules Trileptal oxcarbazepine tablets , oral suspension Vimpat lacosamide tablets, injection a – currently available as generic
Contemporary management of skin cancer – dermatology, surgery or radiotherapy?

Raki skóry s1 najczêstszymi nowotworami z3oœliwymi i stanowi1 ok. 1/3 wszystkich wykrywanych nowotworów [1]. W ostatnich dziesiêcioleciach ogólna zachorowalnoœæ wzrasta o 10–15 proc. rocznie. Jakkolwiek s1 to nowotwory miejscowo z3oœliwe i rzadko daj1ce przerzuty, to ich znaczenie jest du¿e ze wzglêdu na czêstoœæ wystêpowania i lokalizacjê. Ich g3ówn1 cech1 kliniczn1 jest naciekanie okolicznych tkanek i niszczenie s1siaduj1cych struktur. Z tego powodu staj1 siê powodem powa¿nych defektów kosmetycznych, maj1cych istotny wp3yw na jakoœæ ¿ycia chorych [2, 3]. W dostêpnej literaturze zauwa¿alny jest wyraŸny niedostatek publikacji traktuj1cych o dostêpnych metodach leczenia raków skóry oraz brak jasnych zestawieñ wyników terapii uzyskiwanych przez specjalistów z takich dziedzin medycyny, jak dermatologia, chirurgia i radioterapia onkologiczna. Wiele wskazuje na to, ¿e wyniki poszczególnych metod leczniczych s1 porównywalne wzglêdem siebie, a ró¿nice dotycz1 czêstoœci wystêpowania dzia3añ ubocznych leczenia i jego wp3ywu na jakoœæ ¿ycia pacjenta. Celem niniejszego opracowania jest zaprezentowanie podstawowych informacji na temat biologii, symptomatyki i strategii leczenia raków skóry.
Tilted bi‐sense circularly‐polarized antenna and its application for radio frequency identification system

A tilted bi‐sense circularly polarized (CP) antenna and its application for UHF radio frequency identification (RFID) system is proposed. A planar concial monopole working as the electric dipole is designed at first. When a shorting pin is added, a loop radiator would be generated, and thus a pair of orthogonally oriented complementary dipoles is realized. In this way, both right‐handed circularly polarized (RHCP) and left‐handed circularly polarized waves (LHCP) are generated simultaneously in tilted directions within one hemisphere. Then, closed‐form formulas are derived to reveal the tunability mechanism of bi‐sense property and provide a design guideline for system application. It is demonstrated that flare angle of conical monopole has a linear relationship and sine function to CP beam direction and 3‐dB axial ratio (AR) beamwidth, respectively. Finally, antenna prototypes are fabricated and tested for validation. It is also demonstrated that at the tilted direction of θ = ± 45°, a 3‐dB AR bandwidth of 4.9%, and gain up to 5 dB are realized. Comparing with conventional microstrip patch antenna, an enhanced reading range over 5 m can be obtained in the tilted range from 40° to 75° and − 75° to −40° in UHF RFID sytem application.
Management of low rectal gastrointestinal stromal tumor with neoadjuvant therapy and transanal excision: a rare case report and review of the literature

Background Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. However, rectal GISTs represent only 5% of this category. We report a case of a rectal GIST treated with local excision after neoadjuvant therapy. Case presentation A 41-year-old male patient presented with anal bleeding. Colonoscopy revealed a mass located 5 cm from the anal verge. Histological examination showed a GIST with immunohistochemical positivity for CD117 and CD34. Transanal local excision was performed after neoadjuvant therapy. Conclusion Neoadjuvant immunotherapy for GISTs with unfavorable localization may facilitate local excision and avoid complications of more demanding operations.
Upregulated expression of ACTL8 contributes to invasion and metastasis and indicates poor prognosis in colorectal cancer

Background ACTL8 is a member of the CT antigens. There are only few studies on the role of ACTL8 in malignant tumors. The aim of this study is to investigate the expression and clinical significance of ACTL8 protein in colorectal cancer (CRC). Materials and methods Human CRC tissues and cell lines, and paired adjacent non-tumor tissues and human intestinal epithelial cell lines were obtained to evaluate the expression of ACTL8. The association between protein expression of ACTL8 and clinicopathological parameters and prognosis of CRC patients was examined. The biological functions of ACTL8 in the invasion and metastasis of CRC were determined by wound healing and transwell invasion assays after silencing of ACTL8 in CRC cell lines. The potential target genes of ACTL8 were also identified by quantitative reverse transcription PCR and Western blotting after silencing of ACTL8 in CRC cell lines. Results It was found that ACTL8 was upregulated in human CRC tissues and cell lines. The expression of ACTL8 was positively associated with poor differentiation, invasion and metastasis, postoperative infection, and poor prognosis, but negatively associated with proximal margin length. In addition, silencing of ACTL8 significantly decreased the capacity of invasion and migration in HT29 and SW620 CRC cell lines. Moreover, silencing of ACTL8 significantly decreased the expression of TRIM29 in HT29 and SW620 CRC cell lines. Conclusion These results suggest that ACTL8 plays a key role in the invasion and metastasis of CRC, and TRIM29 may be involved in the ACTL8-mediated poor prognosis of CRC.
Optical coherence tomography angiography features in patients with idiopathic full-thickness macular hole, before and after surgical treatment

Purpose To present optical coherence tomography (OCT) angiography features in patients with idiopathic full-thickness macular hole before and after vitrectomy. Study design Prospective case series study. Materials and methods Patients presenting with an idiopathic full-thickness macular hole (IMH) who underwent posterior vitrectomy with internal limiting membrane peeling and gas tamponade were included in the study. En face OCT and OCT angiography (OCTA) was performed pre- and postoperatively using 3×3 mm scans (Optovue, XR Avanti). Foveal avascular zone (FAZ) area, macular hole size (MHS), central retinal thickness (CRT), macular parafoveal choriocapillary flow area (MCFA), and fovea vessel density (FVDS) were measured and assessed using OCTA. Best-corrected visual acuity (BCVA) was examined before and 3 months after surgery. Results Twenty-eight eyes of 28 patients were included in the study. The mean age of patient group was 68.28 years. The hole was closed in all eyes after the initial surgery. OCTA showed enlargement of FAZ and increased CRT in foveal area. Mean preoperative FAZ area was 0.39±0.07 mm2. En face images of the middle retina showed a range of preoperative cystic patterns surrounding the hole. BCVA was improved from 0.1±0.11 preoperatively to 0.42±0.17 postoperatively. Mean FAZ area was reduced to 0.24±0.07 mm2 postoperatively with resolution of macular hole and adjacent cystic areas. Mean CRT was reduced from 396±62.6 µm pre-operatively to 272±30.7 µm postoperatively. After vitrectomy, the parafoveal choriocapillary flow area and FVDS of IMH eyes increased compared with the preoperative measurements. Conclusion Quantitative evaluation of vascular and morphological changes following IMH surgery using OCTA shows the potential for recovery due to vascular and neuronal plasticity. OCTA showing vascular changes and their quantitative characteristics might be a useful tool for the assessment of macular holes before and after surgical treatment.