Miracle-dz/UniFAR-FTUs huggingface dataset:
Mechanism of Autism Spectrum Disorder and The Involvement of microRNA

Autism Spectrum Disorder or ASD refers to a broad range of neurodevelopmental disorder characterised by persistent deficits in social abilities, repetitive behavioural pattern and restricted interest propensity that usually developed throughout childhood. It is referred as spectrum disorder due to its wide variation of subsets that includes several conditions. Autism is referred as spectrum of disorders with wide range of subtypes due to its aetiologically diverse nature. Even each person with ASD within the same subsets may experience a distinct set of strengths and challenges in terms of learning, thoughts and problem-solving ranging from highly skilled to being severely affected. The genesis of it is incompletely comprehensible despite numerous studies have been done to elucidate the pathogenic mechanisms beneath this whole range of impaired neurodevelopmental condition. In this review, literature search was performed with primary focus was given to known mechanism of ASD and specific involvement of microRNA. Given the complexity of ASD with diversity of clinical manifestations, it can be considered as multifactorial aetiopathogenesis disorder that is associated with diverse genetic factors that may also be predisposed by environmental exposures and prenatal factors. Environmental risk factor that may modulate the genetic factors predisposing towards ASD includes advanced parental age, prenatal and perinatal factors, medications and toxic materials exposure. This is supported by epigenetic theory which in other words, the environmental risk factors may increase the tendency for the abnormal genes to be expressed at much earlier stage without changing the primary DNA sequence. Meanwhile, spontaneous de novo mutation and neurobiological factors have been proposed to be the factors contributing to ASD. Currently, there are a lot of studies pivoting on identifying the microRNA involved in dysregulation of gene expression in autistic individuals by microRNA expression profiling. These approaches were able to elucidate the specific microRNAs that involves in regulating gene expression at post-transcriptional level. Subsequent pathway analysis had enabled the understanding of potential mechanisms that lead to ASD. As ASD is a heterogenous disorder in nature, the quest to reveal its definite mechanism is challenging. Genetic, neurobiological and environmental factors were regarded as its main causes. A growing number of reports have supported the involvement of microRNA in the mechanism of ASD. Detection of microRNA in extracellular fluids such as serum, saliva and plasma are the key to identify pathways and processes involved in ASD pathophysiology. Further preclinical validation of these microRNAs target transcripts may be beneficial to support its clinical application. Validated microRNAs may potentially use as non-invasive biomarker in early detection and later on opening up opportunities for future potential therapies for ASD. Keywords— Autism; Gene expression; Mechanism; MiRNA.
A CRITICAL REVIEW OF THE LITERATURE ON THE CONCEPT OF JOB MISMATCH AND OVEREDUCATION

Job-education mismatch and overeducation issues among graduates have been discussed extensively, specifically related to the incidents, determinants, methods of measurement, and the effects of the mismatch. Despite this, the concept of job-education mismatch itself is not clearly explained. Since understanding this concept has theoretical and practical implications, this paper provides a critical review of the job mismatch concept and relates it to overeducation, which is a type of job-education imbalance under a vertical mismatch. This study relies solely on the literature review and does not provide any empirical evidence related to these concepts. A few issues have been highlighted and worth considering for further deliberation. Firstly, even though job-education mismatch, overeducation, overqualification, and underemployment are interchangeably used, these concepts have quite a distinct meaning. Secondly, when individuals’ skills are considered in discussing vertical and horizontal mismatch, the scope of mismatch tends to be broader than that of overeducation. Thirdly, the discussion on overeducation tends to concentrate on the level of study imbalance and not on both the level and type of study. Fourthly, job-education imbalance by the field of study (horizontal mismatch) is not easily defined, and the discussion tends to be related to overeducation.
PVC-SLP: Perceptual Vibrotactile-Signal Compression Based-on Sparse Linear Prediction

Developing a signal compression technique that is able to achieve a low bit rate while maintaining high perceptual signal quality is a classical signal processing problem vigorously studied for audio, speech, image, and video type of signals. Yet, until recently, there has been limited effort directed toward the compression of vibrotactile signals, which represent a crucial element of rich touch (haptic) information. A vibrotactile signal; produced when stroking a textured surface with a tool-tip or bare-finger; like other signals contains a great deal of redundant and imperceptible information that can be exploited for efficient compression. This paper presents PVC-SLP, a vibrotactile perceptual coding approach. PVC-SLP employs a model of tactile sensitivity; called ASF (Acceleration Sensitivity Function); for perceptual coding. The ASF is inspired by the four channels model that mediate the perception of vibrotactile stimuli in the glabrous skin. The compression algorithm introduces sparsity constraints in a linear prediction scheme both on the residual and the predictor coefficients. The perceptual quantization of the residual is developed through the use of ASF. The quantization parameters of the residual and the predictor coefficients were jointly optimized; by means of both squared error and perceptual quality measures; to find the sweet spot of the rate-distortion curve. PVC-SLP coding performance is evaluated using two publicly available databases that collectively comprise 1281 vibrotactile signals covering 193 material classes. Furthermore, we compare PVC-SLP with a recent vibrotactile compression method and show that PVC-SLP perceptually outperforms existing method by a sizable margin. Most recently, PVC-SLP has been selected to become part of the haptic codec standard currently under preparation by IEEE P1918.1. 1, aka Haptic Codecs for the Tactile Internet.
The “Talk Test” is a practical tool to determine aerobic training zones in overweight and obese patients.

Background: to validate the traditional talk test (TTT) and an alternative talk test (ATT; using a visual analog scale) in overweight/obese (OW-OB) patients and to establish its accuracy in determining the aerobic training zones.Methods: We recruited 19 subjects aged 34.9 ± 6.7 years, diagnosed with overweight/obesity (BMI 31.8 ± 5.7). Every subject underwent incremental cycloergometric tests for maximal oxygen consumption, and TT in a randomized order. At the end of each stage during the TT each subject read out loud a 40 words text and then had to identify the comfort to talk in two modalities: TTT which consisted in answering “Yes”, “I don’t know” or “No” to the question Was talking comfortable? , or ATT through a 1 to 10 numeric perception scale (visual scale analog: VAS). The magnitude of differences was interpreted in comparison to the smallest worthwhile change (SWC) and was used to determine agreement.Results: Agreement between the power output at the VAS 2-3 of ATT and the power output at the ventilatory threshold 1 (very likely equivalent; mean difference -1.3 W, 90 % CL (-8.2; 5.6), % chances for higher/similar/lower values of 0.7/99.1/0.2 %). Also, there was an agreement between the power output at the VAS 6-7 of ATT and the power output at the ventilatory threshold 2 (very likely equivalent; mean difference 11.1 W, 90 % CL (2.8; 19.2), % chances for higher/similar/lower values of 0.0/97.6/2.4 %). Conclusions: ATT is a tool to determine exercise intensity and to establish aerobic training zones for exercise prescription in OW-OB patients.
R&D investment intensity, green energy technology innovation and construction firm growth performance

Based on the data of listed construction companies in the jewelry manufacturing industry in 1994 from 2014 to 2017, this article uses the generalized least squares method to analyze the relationship between green energy technology innovation, construction enterprises’ growth performance and R&D investment intensity, and explores the impact of green energy technology innovation on construction enterprises’ growth performance and analyzes the moderating effect of R&D investment intensity. The empirical results show that green energy technological innovation has a significant positive impact on construction enterprises’ growth performance. The intensity of R&D investment has a significant negative regulatory effect on the relationship between green energy technological innovation and construction enterprises’ growth performance.
Quality of life of patients with terminal stage of chronic kidney disease

WHO defines quality of life (QL) as "an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns". Health related QL is an evaluation of QL and its relationship with health. The aim. To analyse quality of life components in patients with chronic kidney disease (CKD), stage V. For this 68 CKD (stage V) patients have been under examination. By assessing physical activity, performance, clinical and laboratory data, an objective assessment of QL have been made. The patient's subjective perception of his illness and social adaptation makes it possible to determine with great accuracy the measures necessary for the medical and social rehabilitation of patients on program and peritoneal dialysis. Conclusion. In the terminal stage of CKD, the patients’ QL and its individual components deteriorate significantly. According to general health, physical, mental well-being, social functioning, the lowest assessment of QL was found in patients of the hemodialysis group.
Production of Amylase by Arthrobacter kerguelensis VL - RK_09 Isolated from Mango Orchards

Objectives: To optimize the cultural parameters for improved production of amylase by Arthrobacter kerguelensis VL-RK_09 isolated from Mango orchards of Vissannapet, Krishna District, A.P., India. Methods: The strain A. kerguelensis was screened initially for amylase production on Inorganic salts starch agar medium (ISP-4). The enzyme assay was performed as per the procedure described by Bernfield (1955). One amylase unit equals to that amount of enzyme needed to release 1 mg of reducing sugar (maltose as standard) for 15 min at 37°C. Attempts were also made to optimize cultural parameters such as pH, temperature, carbon and nitrogen sources affecting the production of amylase by the strain. Results: Maximal yields of amylase were recorded after 4 days of incubation in Inorganic salts starch medium with initial pH 7.0 and temperature 35°C. ISP-4 broth amended with sorghum flour (2%) and yeast extract (0.5%) with initial pH 7.0 inoculated with Arthrobacter kerguelensis VLRK_09 and incubated at 30°C for 96 h resulted in improved production of amylase from initial 4.0 U to 10.4 U/mL. Conclusion: This is the first report on the production and optimization of amylase by A. kerguelensis and further studies on purification and characterization of the enzyme are in progress. Original Research Article Munaganti et al.; BBJ, 8(4): 1-10, 2015; Article no.BBJ. 19383 2
Analysis of learners’ cognitive competences and the effective teaching of pupils with learning disabilities:A case study of hope academy nursery and primary school in Buea Fako sub- division of Cameroon

The study set out to analyse the cognitive competence of children (7years and above) as a basis for the effective teaching of children with learning disability. The study examined the extent to which the analysis of pupils' executive function and visual perception competences influence the effective teaching of children with learning disability. A pre-test post-test quasi- experimental research design was used and participants were selected purposively. A sample size of 10 pupils with learning disability was used. A diagnostic test and an observation checklist with items corresponding to the needs of the pupils was used to analyze pupils’ cognitive competences while a written test was used to establish the extent of teacher effectiveness. A reliability test was conducted to assess internal consistency using the Cronbach’s Alpha coefficient reliability analysis which stood at 0.84. Data collected from the field were subjected to both descriptive and inferential statistics. Findings showed that both executive functions and visual perception analysis have a significant influence on the effective teaching of reading and writing to children with learning disabilities. Recommendations included the fact that policies and proper mechanisms be put in place to ensure that teachers are adequately trained and equipped with modern teaching and learning strategies that will enable them accommodate learners with learning disability
Coordination chemistry of bis(.delta.-camphorquinone dioximato)nickel(II) and -palladium(II). Reactions and structural studies of some M3Ag3 cluster complexes of camphorquinone dioxime

Reactions of AgNO/sub 3/ with Ni(delta-HCQD)/sub 2/ or Pd(delta-HCQD)/sub 2/, where delta-HCQD/sup -/ is delta-camphorquinone dioximato, yielded the hexanuclear metal cluster complexes (Ni(delta-HCQD)/sub 2/Ag)/sub 3/ x 2.5CHCl/sub 3/, Ni-Ag, and (Pd(delta-HCQD)/sub 2/Ag)/sub 3/ x 2CHCl/sub 3/, Pd-Ag, respectively. X-ray crystallographic studies performed on both complexes showed them to belong to space group P2/sub 1/2/sub 1/2/sub 1/. The unit cell dimensions of Ni-Ag are a = 15.990 (5) A, b = 38.44 (1) A, c = 13.437 (5) A, V = 8260.97 A/sup 3/, and Z = 4 while those of Pd-Ag are a = 16.110 (6), b = 38.92 (1), c = 13.393 (3) A, V = 8395.55 A/sup 3/, and Z = 4. Block-diagonal least-squares refinement of 3021 observed reflections for Ni-Ag and 6112 for Pd-Ag converged to R/sub F/ = 10.7 and 11.4 (R/sub w/ = 12.7 and 15.0) for the Ni-Ag and Pd-Ag structures, respectively. Their structures indicate that each hexanuclear molecule consists of three individual M(delta-HCQD)/sub 2//sup -/ units which act as multidentate ligands coordinating to a linear chain of three silver atoms. The coordination geometry around each M ion in the M(delta-HCQD)/sub 2//sup -/ units is square planar, and the delta-HCQD/sup -/ ligands are coordinatedmore » to M via N and O atoms. The Ag in the center of the molecule is coordinated to six O atoms with average Ag-O distances of 2.49 (3) and 2.45 (2) A for Ni-Ag and Pg-Ag, respectively. The two silver atoms at the ends of the chain are each coordinated to three nitrogen atoms from the M(delta-HCQD)/sub 2//sup -/ units with average Ag-N distances of 2.20 (4) and 2.27 (3) A, respectively. The Ag-Ag distances, 3.059 (5) and 3.052 (5) A in Ni-Ag and 3.173 (3) and 3.179 (3) A in Pd-Ag, are somewhat longer than those (2.89 A) in Ag metal and indicate that there are Ag-Ag interactions along the linear chains. The bis(pyridine) adduct of Ni(delta-HCQD)/sub 2/ was also prepared. A proposed structure for this complex is based on the similarity of its ir spectrum to those of the Ni-Ag and Pd-Ag clusters. « less
Integration of Interturn Fault Diagnosis and Torque Ripple Minimization Control for Direct-Torque-Controlled SPMSM Drive System

This article proposes an integration method for interturn fault diagnosis and torque ripple minimization control of direct-torque-controlled surface-mounted permanent magnet synchronous machine (SPMSM) drive system without requiring the specific fault severity (short-circuited turn ratio, current). In this method, the interturn fault is detected and located based on the amplitude and initial phase angle of the zero-sequence voltage component (ZSVC). Both the torque injection and the improved flux observer are applied to reduce the torque ripple caused by the interturn fault. Furthermore, the torque injection and the improved flux observer are directly calculated by using the already obtained amplitude and initial phase angle of the ZSVC during the fault diagnosis process, without requiring the specific values of short-circuited turn ratio and fault current. The experimental results validate the effectiveness of the proposed integration method for the direct-torque-controlled SPMSM drive system.
Recent Advances in Electrochemical Sensors for Wearable Sweat Monitoring: A Review

Thanks to rapid technological innovation over the last decade, a wide range of wearable devices have emerged, playing an inspiring role in healthcare, diagnostics, and sports monitoring. This review summarizes recent progress in the development and application of electrochemical (EC) sweat sensors and self-powered systems for wearable applications. Presented here are the most common types of EC sweat sensors, namely potentiometric ion-selective electrodes, amperometric enzymatic and non-enzymatic sensors, as well as differential pulse voltammetric sensors. The sensing principle and novel functional nanomaterials that are used to enhance the performance of wearable sweat sensors and their applications are summarized. The recent advancement of battery-free wearable devices is presented, including self-powered biofuel cells (BFC), energy harvesting from novel materials and its strategy, are also discussed. The challenges in, and opportunities for, the development of sweat sensor-based wearable systems moving forward are reviewed, with the aim of shedding some light on future directions.
Does Anyone Really Identify with FemShep?

This chapter argues that we should understand identity in video games as a way to value incommensurable difference rather than organized diversity. It focuses on FemShep, the female version of the Mass Effect trilogy’s Commander Shepard, who became an icon of diversity and inclusion in conversations about video games. FemShep is not a fully realized woman in her own right, but a character designed as a man and minimally altered to become a “woman. ” The chapter explores the ways that Mass Effect betrays these origins through improbable animations and relationship choices, comparing it to similar oversights in Lionhead Studios’ Fable 2, and then suggests that it is the fact that FemShep is not a fully realized character that makes her a useful rallying point for political gamers. The chapter closes by drawing from Black feminists Kara Keeling and Audre Lorde to propose that “unity in difference” is the future (and past) of identity politics, and that the individualist war hero so popular in video games is no way to implement a politics of coalition and justice.
PEDAGOGICAL CONDITIONS OF COMMUNICATIVE COMPETENCE DEVELOPMENT OF FUTURE TEACHERS OF ENGINEERING DISCIPLINES

The article attempts to concretize the concept of «communicative competence» of future teachers of engineering disciplines as dynamic integrative professionally-important personal quality, providing the productive intercultural professional interaction in solving engineering and pedagogical problems and communication situations in the process of pedagogical activity, and including the motivationally-valuable, cognitive, activity, reflexive and evaluative components ; to substantiate and develop the pedagogical conditions for formation of communicative competence. The author of the article emphasizes that the communicative competence development of future teachers of engineering disciplines will be effective under the following pedagogical conditions: the enrichment of training content with material, updating the value of interpersonal and intercultural professional communication, which is reflected in the expansion of the content by providing the intellectual development of the students and the development of metacapabilities, metaknowledge, professional and personal qualities through the implementation of the principles of thematic interdisciplinary integration, diversity, multifunctionality and dynamism; substantive and continuous updating of the communicative educational environment as a cooperative product and as a process of communicative interaction, based on the systematic integration of human and professional contexts; activation of student activities in the communicative educational environment by student-centered pedagogical technologies using the pedagogical support of students. The article identifies the need to use the principle of thematic interdisciplinary integration as a way of pedagogical conditions realization, providing the communicative competence development, in which the ability to work well as part of a team, cooperation and social adaptation skills are developed and formed, significant for communicative competence. The author proposes a way to implement the principle of thematic interdisciplinary integration in the form of project methods, web projects, and portfolio as effective ways to create a meaningful, professional, creative/research product, which contributes to the communication skills intensification of future teachers of engineering disciplines.
O Modelo GAS-Agro para Projetos de Desenvolvimento Sustentável

Impossível falar do tema sustentabilidade sem mencionar John Elkington (1998) com o modelo do Triple Botton Line (TBL) no qual defende que as empresas não podem se dissociar de três dimensões: PPP (people, planet and profit) social, ambiental e econômica; quando um destes pilares está em falta, a organização não se sustenta e prejudica outras partes que estão envolvidas direta ou indiretamente com ela. O autor também enfatizou a importância da interação e cooperação entre diversos agentes de um setor como empresas privadas, governo, comunidade e que devem seguir um ritmo comum, chegando a um determinado equilíbrio relacionando a lucratividade e sustentabilidade, em uma relação de dependência. O pilar ambiental refere-se à “conservação e ao manejo dos recursos naturais” e o pilar social diz respeito ao “alcance da igualdade e a participação de todos os grupos sociais na construção e manutenção do equilíbrio do sistema pelo compartilhamento de direitos e responsabilidades” (Munck et al., 2008).
Static Properties of Neutron-Rich and Proton-Rich Isotopes

In this paper, we have investigated some static properties of 9Be, 9B, 13C, 13N, 17O, 17F, 21Ne, and 21Na isotopes. The ground state and excited state energy of these isotopes have determined in the relativistic shell model and compared with experimental data. The calculated charge radius of them is in good agreement with experimental results.
Rhodium-catalysed tandem dehydrogenative coupling–Michael addition: direct synthesis of phthalides from benzoic acids and alkenes

[(COD)RhCl]2 catalyses the coupling of benzoic acids and alkenes in the presence of Cu(OAc)2·H2O and dicyclopentadiene to afford phthalides in 15–93% yield. A 3-substituted or 3,7-disubstituted product is obtained selectively depending on alkene type. The reaction is highly atom-economical and uses readily available starting materials.
IMMUNE STATUS AND PROCESSES OF LIPID PEROXIDATION IN PATIENTS WITH HYPERTENSION

According to modern concepts, lipid peroxidation (LPO) is a constantly occurring physiological process that, when intensified, is involved in the development of a number of pathologies. It has been established that activation of LPO processes is involved in the pathogenesis of many diseases of the cardiovascular system [2]. Lipid peroxides play an important role in the body: lipoperoxides are an important intermediate in the biosynthesis of prostaglandins E, progesterone; they are involved in the hydroxylation of the cholesterol core; they are necessary for activating a number of membrane processes and regulating membrane permeability.