Miracle-dz/UniFAR-FTUs huggingface dataset:
Uso de una red social segura para el estudio de la ansiedad en la adolescencia

El objetivo del trabajo es presentar brevemente el Proyecto TrANS y los primeros resultados obtenidos a traves de dos estudios. Este Proyecto permite el estudio de las trayectorias de la sintomatologia ansiosa y la ansiedad-estado en adolescentes mediante el uso de las TIC, en concreto una red social segura para la recogida de datos. En el Estudio 1 se describe la estructura y funcionamiento de la red social segura XS2, ademas de proporcionarse resultados sobre el acceso y uso de los participantes. En el Estudio 2 se presentan los resultados de las variaciones del estado emocional cotidiano y el uso de estrategias de regulacion emocional desadaptativas durante un periodo de examenes, asi como la influencia de factores de riesgo sobre ellas. Se destacan las ventajas del uso de una red social segura respecto a otros metodos tradicionales de recogida de datos para el estudio de la ansiedad en la adolescencia.
Immunoperoxidase localization of glial fibrillary acidic protein in radial glial cells and astrocytes of the developing rhesus monkey brain

Peroxidase‐antiperoxidase (PAP) immunohistochemical staining, utilizing a specific antibody to the glial fibrillary acidic protein (GFA), was employed to analyze gliogenesis in the central nervous system of rhesus monkeys ranging in age from embryonic day 38(E38) to birth (E165) and through the second postnatal month. All major subdivisions of the brain contain glial cells, recognized by the presence of dark brown horseradish peroxidase (HRP) reaction product. Neuronal elements are not stained with this immunocytochemical technique.
Identification of Bari Transposons in 23 Sequenced Drosophila Genomes Reveals Novel Structural Variants, MITEs and Horizontal Transfer

Bari elements are members of the Tc1-mariner superfamily of DNA transposons, originally discovered in Drosophila melanogaster, and subsequently identified in silico in 11 sequenced Drosophila genomes and as experimentally isolated in four non-sequenced Drosophila species. Bari-like elements have been also studied for their mobility both in vivo and in vitro. We analyzed 23 Drosophila genomes and carried out a detailed characterization of the Bari elements identified, including those from the heterochromatic Bari1 cluster in D. melanogaster. We have annotated 401 copies of Bari elements classified either as putatively autonomous or inactive according to the structure of the terminal sequences and the presence of a complete transposase-coding region. Analyses of the integration sites revealed that Bari transposase prefers AT-rich sequences in which the TA target is cleaved and duplicated. Furthermore evaluation of transposon’s co-occurrence near the integration sites of Bari elements showed a non-random distribution of other transposable elements. We also unveil the existence of a putatively autonomous Bari1 variant characterized by two identical long Terminal Inverted Repeats, in D. rhopaloa. In addition, we detected MITEs related to Bari transposons in 9 species. Phylogenetic analyses based on transposase gene and the terminal sequences confirmed that Bari-like elements are distributed into three subfamilies. A few inconsistencies in Bari phylogenetic tree with respect to the Drosophila species tree could be explained by the occurrence of horizontal transfer events as also suggested by the results of dS analyses. This study further clarifies the Bari transposon’s evolutionary dynamics and increases our understanding on the Tc1-mariner elements’ biology.
Self-organizing networks for 5G: Directional cell search in mmW networks

We discuss the motivation and potential use-cases of self-organizing networks (SON) in 5G networks. Disruptive technologies and features of 5G networks include millimeter wave (mmW), massive multiple-input multiple output (MIMO), and cloud-radio access network (C-RAN). These have ramifications on SON aspects of the networks. We discuss several new SON use-cases and problems pertinent to emerging 5G technologies. The discussed 5G SON use-cases include spectrum management and sharing, user association, multi-radio access technology (RAT) optimization, and directional cell search for mmW networks. We then investigate directional cell search in detail, and consider a network graph based approach for self-organized beam assignment in mmW 5G networks. Simulations results in a realistic Manhattan environment demonstrate the benefits of proposed approach, in terms of improved user signal-to-interference plus noise ratios to potential handover beams, thereby resulting in better directional cell discovery.
High dielectric constant oxides

The scaling of complementary metal oxide semiconductor (CMOS) transistors has led to the silicon dioxide layer used as a gate dielectric becoming so thin (1.4 nm) that its leakage current is too large. It is necessary to replace the SiO2 with a physically thicker layer of oxides of higher dielectric constant (κ) or 'high K' gate oxides such as hafnium oxide and hafnium silicate. Little was known about such oxides, and it was soon found that in many respects they have inferior electronic properties to SiO2 ,s uch as a tendency to crystallise and a high concentration of electronic defects. Intensive research is underway to develop these oxides into new high quality electronic materials. This review covers the choice of oxides, their structural and metallurgical behaviour, atomic diffusion, their deposition, interface structure and reactions, their electronic structure, bonding, band offsets, mobility degradation, flat band voltage shifts and electronic defects. The use of high K oxides in capacitors of dynamic random access memories is also covered.
Rituximab ( Anti-CD 20 Monoclonal Antibody ) for the Treatment of Patients With Relapsing or Refractory Aggressive Lymphoma : A Multicenter Phase II Study

Rituximab, a chimeric monoclonal antibody that binds specifically to the CD20 antigen, induced objective responses in 50% of patients with low-grade or follicular B-cell lymphoma. Because most nonfollicular B-cell lymphomas also express the CD20 antigen, we conducted a phase II study to evaluate the efficacy and tolerability of this new agent in patients with more aggressive types of lymphoma. Patients with diffuse large B-cell lymphoma (DLCL), mantle cell lymphoma (MCL), or other intermediateor high-grade B-cell lymphomas according to the Working Formulation were included in this prospective randomized phase II study if they were in first or second relapse, if they were refractory to initial therapy, if they progressed after a partial response to initial therapy, or if they were elderly (age G60 years) and not previously treated. The patients received 8 weekly infusions of rituximab at the dose of 375 mg/m2 in arm A or one infusion of 375 mg/m2 followed by 7 weekly infusions of 500 mg/m2 in arm B. Patients were evaluated 2 months after the last rituximab infusion. Fifty-four patients were randomized from 9 centers in Europe and Australia (28 in arm A and 26 in arm B). A total of 5 complete responses (CR) and 12 partial responses (PR) were observed among the 54 enrolled patients, with no difference between the two doses. In an intent-to-treat analysis, the CR rate was 9% (CI95%, 3% to 20%) and the PR rate was 22% (CI95%, 12% to 36%), for an overall response rate of 31% (CI95%, 20% to 46%). An analysis of prognostic factors showed that response rates were lower in patients with refractory disease, patients with lymphoma not classified as DLCL, and patients with a tumor larger than 5 cm in diameter. DLCL and MCL patients had response rates of 37% and 33%, respectively. The median time to progression exceeded 246 days for the 17 responding patients. The most frequently reported adverse events were related to an infusion syndrome and were mild: 19% of the patients had a grade 3 related adverse event, slightly more in arm B, and only 1 patient had a grade 4 related adverse event in arm A. Two patients (3.7%) withdrew from treatment because of severe adverse events, one patient in each arm. In this first trial of rituximab in DLCL and MCL, patients experienced a significant clinical activity with a low toxicity. Rituximab has significant activity in DLCL and MCL patients and should be tested in combination with chemotherapy in such patients. r 1998 by The American Society of Hematology.
Research on intelligent fault diagnosis method for complex equipment based on decision-level fusion

Rough Bayesian network classifier (RBNC) not only has the ability of rough set (RS) for analyzing and reducing data, but also holds the advantage of Bayesian network (BN) for parallel reasoning, and it has been successfully used in fault diagnosis field. However, single RBNC sometimes will produce misdiagnosis because of many uncertainty factors in practical diagnostic process. In order to improve the accuracy rate and reduce the uncertainty, a new decision-level fusion diagnosis method was proposed based on D-S evidence theory. Firstly, the RNBC models are taken as evidences and the posterior probability values of all fault types as correlation coefficients. Then, all evidences are synthesized by using the combination rule of evidence theory, and consequently, the diagnostic result can be gained by the decision-making method based on the basic probability number. Finally, the validity and engineering practicability of the proposed method is demonstrated by an example of fault diagnosis for diesel engine, and the results show that the proposed method is more effective than the RS method and the BN method and the RBNC method.
Melhorando o Processo de Engenharia de Requisitos em Empresas de Produtos de Software - Um Estudo de Caso

Resumo. O desenvolvimento de produtos de software para um amplo mercado consumidor é uma tendência mundial. Atualmente, um número crescente de empresas de software desenvolve produtos visando atender a necessidade de inúmeros clientes, distribuídos geograficamente. Esta forma de desenvolvimento afeta profundamente o processo de engenharia de requisitos. Neste artigo apresentamos uma experiência de transferência tecnológica em engenharia de requisitos com empresas de produtos de software. O estudo de caso na PROCENGE, empresa desenvolvedora de produtos Enterprise Resource Planning é apresentado para discutir as lições aprendidas durante o programa de melhoria em engenharia de requisitos.
Development of a pediatric cariogenicity index.

OBJECTIVES This study was designed to develop food and liquid cariogenicity indices and to preliminarily test their utility using dietary data from a study of children with and without severe early childhood caries (S-ECC), defined as 3 + smooth surface carious lesions, including at least one pulpally involved tooth. METHODS Data were collected in a diverse cohort of low-income preschool-aged children made up of 454 children with S-ECC and 429 caries-free children who presented for care at pediatric dental clinics in Washington, DC, Columbus, OH, and Cincinnati, OH. The cariogenicity indices were used to score dietary data from a Food Frequency Questionnaire (FFQ) and a 24-hour recall (24HR). RESULTS There were no statistically significant differences in mean food cariogenicity scores between groups. The liquid cariogenicity score was higher in the S-ECC group as compared with caries-free children (24HR: 5.28 versus 4.66, respectively, P < 0.001; FFQ: 5.03 versus 4.38, P < 0.001). The food cariogenicity score did not discriminate between those with and without S-ECC, while the liquid cariogenicity score did differentiate between the two groups (24HR: OR: 1.2; 95 percent CI: 1.1, 1.3; FFQ: 1.7; 95 percent CI 1.4, 2.0). The liquid cariogenicity score was also associated with number of carious lesions. CONCLUSIONS The liquid cariogenicity index has potential in research and clinical settings to provide a liquid cariogenicity score and help quickly identify modifiable risk factors within a child's diet. Further research is needed to test its utility in clinical and public health settings.
The Axes of Rotation of the Knee

Knee motion is believed to occur about a variable flexion–extension (FE) axis perpendicular to the sagittal plane and a longitudinal rotation (LR) axis. The authors used a mechanical device to locate the FE and the LR axes of six fresh anatomic specimen knees. The motion of points on the LR axis produced circular, planar paths about the fixed FE axis. Magnetic resonance (MR) images in planes perpendicular to the FE axis showed a circular profile for the femoral condyles. The FE axis is constant and directed from anterosuperior on the medial side to posteroinferior on the lateral side, passing through the origins of the medial and lateral collateral ligaments and superior to the crossing point of the cruciates. The LR axis is anterior and not perpendicular to the FE axis, the anatomic planes. This offset produces the valgus and external rotation observed with extension. The implications of two fixed offset axes for knee motion on prosthetic design, braces, gait analysis, and reconstructive surgery are profound.
An analysis of income differentials by marital status

Unmarried cohabitation has become a more frequently observed phenomenon over the last three decades, and not only in the United States. The objective of this work is to examine income differentials between married women and those who remain single or cohabitate. The empirical literature shows that, while the marriage premium is verified in different studies for men, the result for women is not conclusive. The main innovation of my study is the existence of controls for selection. In this study, we have two sources of selectivity: into the labor force and into a marital status category. The switching regressions and the Oaxaca decomposition results demonstrate the existence of a significant penalty for marriage. Correcting for both types of selection, the difference in wages varies between 49% and 53%, when married women are compared with cohabiting ones, and favors non-married women. This result points to the existence of a marriage penalty.
The complete mitochondrial genome of the Megalobrama skolkovii (Cyprinidae: Cultrinae)

Abstract The complete mitochondrial DNA (mtDNA) sequence of Megalobrama skolkovii was first presented in this study. The mitochondrial genome is 16,620 bp in length, including 13 protein-coding genes, 2 ribosomal RNA gens (12S rRNA and 16S rRNA), 22 transfer RNA genes (tRNA) and a control region (D-loop), with the gene identical to that of typical vertebrates. The overall base composition of the light strand are 31.23% A, 24.73% T, 16.16% G and 27.88% C. Two copies of tandem repeat sequence was found in the control region.
Reduced need for alveolar bone grafting by presurgical orthopedics and primary gingivoperiosteoplasty.

OBJECTIVE The purpose of this study was to evaluate if narrowing and approximation of the alveolar cleft through presurgical alveolar molding followed by gingivoperiosteoplasty (GPP) at the time of lip repair reduces the need for a bone-grafting procedure. DESIGN This was a retrospective blind study of patients with unilateral or bilateral alveolar clefts who underwent presurgical infant alveolar molding and GPP by a single surgeon. Alveolar bone formation was assessed prior to the eruption of the maxillary lateral incisor or canine by clinical examination, panoramic and periapical radiographs, and/or a dental CT scan. The criterion for bone grafting was inadequate bone stock to permit the eruption and maintenance of the permanent dentition. SETTING This study was performed at the Institute of Reconstructive Plastic Surgery by the members of the Cleft Palate Team. PATIENTS All patients with unilateral (n = 16) or bilateral (n = 2) alveolar clefts who underwent presurgical infant alveolar molding and GPP by a single surgeon from 1985 to 1988 were studied. The control population consisted of all alveolar cleft patients (n = 14) who did not undergo alveolar modeling or GPP during the same time period. INTERVENTIONS Presurgical alveolar modeling was performed with an intraoral acrylic molding plate. This plate was modified on a weekly basis to align the alveolar segments and close the alveolar gap. The surgical intervention consisted of a modified Millard GPP. MAIN OUTCOME MEASURES The primary study outcome measure was the elimination of the need for a secondary bone graft in patients who underwent presurgical alveolar molding and GPP. RESULTS Of the 20 sites in the 18 patients who underwent GPP, 12 sites did not require an alveolar bone graft. Of the 8 sites requiring a bone graft, 4 presented minimal bony defects. All 14 patients in the control group required bone grafts. CONCLUSIONS In this series of 20 alveolar cleft sites treated with presurgical orthopedics and GPP, 60% did not need a secondary alveolar bone graft in the mixed dentition.
Murder in Plain Sight

the incredibility of the Holocaust has been a central theme of both Holocaust literature and scholarship from their inception. In 1951 Hannah arendt stressed the extent to which the nazis relied on the likelihood that the wild improbability of the scale of their crimes would guarantee that, should they lose the war, they and their preposterous lies would be believed, while their victims would be derided as fantasists: “the nazis did not even consider it necessary to keep this discovery to themselves. Hitler circulated millions of copies of his book in which he stated that to be successful, a lie must be enormous—which did not prevent people from believing him as, similarly, the nazis’ proclamations, repeated ad nauseam, that the Jews would be exterminated like bedbugs (i.e., with poison gas) prevented anybody from not believing them. ” abba Kovner, the commander of the Jewish underground in Vilna, wrote, “that they could all be murdered, the Jews of Vilna, Kovno, Bialystok, Warsaw, the millions with their wives and children—hardly a single one wanted to believe that. What was the meaning of this? Was it just blindness? ” arendt offers an answer: “there is a great temptation to explain away the intrinsically incredible by means of liberal rationalizations. In each one of us, there lurks such a liberal, wheedling us with the voice of common sense. ” nowhere was the incredibility of Germany’s campaign to destroy Jewry more extreme than in Hungary. In Night, the “non-fictional novel” that has long been considered the classic personal account by a Hungarian survivor of the Holocaust, elie Wiesel records the following conversation in auschwitz between a veteran prisoner and a newly arrived one: “‘You’d have done better to have hanged yourselves where you were than to come here. didn’t you know what was in store for you at auschwitz? Haven’t you heard about it? In 1944? ’ no, we had not heard. no one had told us. He could not believe his ears. ” as the historians raul Hilberg and randolph Braham have observed, by 1944, Hungary, with its 750,000 Jews, was the only important area of europe still untouched by deportations to the killing centers. But in March the Germans overran the country, the only time when the organizers of mass murder knew that the war was lost as they began their operations. the Hungarian Jews were almost the only Jews in europe who had full warning and knowledge of what was to come while their community was still unharmed.
Efficacy and toxicity of bendamustine in patients with relapsed low-grade non-Hodgkin's lymphomas

Low-grade non-Hodgkin's lymphomas (NHL) are very sensitive to a broad range of chemotherapeutic and biological agents. Relapses, however, occur even after aggressive cytostatic combinations in first-line therapy. Therefore, effective and well-tolerated salvage therapies are very important. In this single-institution trial, the efficacy and toxicity of bendamustine in the treatment of relapsed low-grade NHL was investigated. Fifty-eight patients with low-grade NHL pretreated with different cytostatic regimens were included. All patients received bendamustine at 120 mg/m2 as a 1-h infusion on 2 consecutive days. The treatment was repeated every 3 weeks until complete remission (CR), partial remission (PR) or stable disease (SD) was confirmed on two consecutive cycles. Efficacy and toxicity were evaluated in 52 patients: CR was induced in 11%, PR in 62% and SD in another 10% of the patients. No response to treatment was seen in 17%. The median duration of remission was 16 months and the median survival time was 36 months. Side effects were generally mild, and restricted to myelosuppression, gastrointestinal toxicity and allergic reactions. Bendamustine proved to be very effective and was well tolerated in pretreated patients with relapsed or primary resistant low-grade NHL.
Ocorrência de adenovírus em crianças com gastrenterite aguda grave na Cidade de Belém, Pará, Brasil

Gastroenteritis is one of the major childhood diseases worldwide. Epidemiological studies have detected adenoviruses in 2% to 22% of cases of acute infantile diarrhea in hospitals and outpatient clinics. Adenoviruses are responsible for 50% of cases of pediatric intestinal intussusception. The aim of this study was to detect the presence of these viruses in stool samples from 380 children younger than 3 years old with symptoms of gastroenteritis in Belém, Pará State, Brazil, with an emphasis on serotype 40/41. The samples came from a surveillance study conducted by the hospital and outpatient clinic of the Instituto Evandro Chagas from March to September 2003. We used EIA and an immunochromatographic technique for screening, and cell culture and PCR for typing. Adenoviruses were found in 6.3% (24/380) of the samples. Enteric adenoviruses (EAds) were present in 3.7% (14/380) of tested samples, which corresponded to 58.3% (14/24) of positive cases. This demonstrated that this virus is the cause of the majority cases of gastroenteritis in children. The most sensitive technique was PCR, which was able to define the serotypes of five samples that were not defined by other methods. EAds predominated in the age group of 18-24 months, and the highest number of cases occurred in March 2003. The average time of hospitalization was approximately six days. The results of this study confirm the circulation of the virus in Belém, demonstrating the importance of adenoviruses as a cause of gastroenteritis in children.
Bacterial genome reduction using the progressive clustering of deletions via yeast sexual cycling

The availability of genetically tractable organisms with simple genomes is critical for the rapid, systems-level understanding of basic biological processes. Mycoplasma bacteria, with the smallest known genomes among free-living cellular organisms, are ideal models for this purpose, but the natural versions of these cells have genome complexities still too great to offer a comprehensive view of a fundamental life form. Here we describe an efficient method for reducing genomes from these organisms by identifying individually deletable regions using transposon mutagenesis and progressively clustering deleted genomic segments using meiotic recombination between the bacterial genomes harbored in yeast. Mycoplasmal genomes subjected to this process and transplanted into recipient cells yielded two mycoplasma strains. The first simultaneously lacked eight singly deletable regions of the genome, representing a total of 91 genes and ∼10% of the original genome. The second strain lacked seven of the eight regions, representing 84 genes. Growth assay data revealed an absence of genetic interactions among the 91 genes under tested conditions. Despite predicted effects of the deletions on sugar metabolism and the proteome, growth rates were unaffected by the gene deletions in the seven-deletion strain. These results support the feasibility of using single-gene disruption data to design and construct viable genomes lacking multiple genes, paving the way toward genome minimization. The progressive clustering method is expected to be effective for the reorganization of any mega-sized DNA molecules cloned in yeast, facilitating the construction of designer genomes in microbes as well as genomic fragments for genetic engineering of higher eukaryotes.