Miracle-dz/UniFAR-FTUs huggingface dataset:
A mutation in protein phosphatase 2A regulatory subunit A affects auxin transport in Arabidopsis.

The phytohormone auxin controls processes such as cell elongation, root hair development and root branching. Tropisms, growth curvatures triggered by gravity, light and touch, are also auxin‐mediated responses. Auxin is synthesized in the shoot apex and transported through the stem, but the molecular mechanism of auxin transport is not well understood. Naphthylphthalamic acid (NPA) and other inhibitors of auxin transport block tropic curvature responses and inhibit root and shoot elongation. We have isolated a novel Arabidopsis thaliana mutant designated roots curl in NPA (rcn1). Mutant seedlings exhibit altered responses to NPA in root curling and hypocotyl elongation. Auxin efflux in mutant seedlings displays increased sensitivity to NPA. The rcn1 mutation was transferred‐DNA (T‐DNA) tagged and sequences flanking the T‐DNA insert were cloned. Analysis of the RCN1 cDNA reveals that the T‐DNA insertion disrupts a gene for the regulatory A subunit of protein phosphatase 2A (PP2A‐A). The RCN1 gene rescues the rcn1 mutant phenotype and also complements the temperature‐sensitive phenotype of the Saccharomyces cerevisiae PP2A‐A mutation, tpd3–1. These data implicate protein phosphatase 2A in the regulation of auxin transport in Arabidopsis.
Emotional Disturbance or Social Misperception? An Important Classroom Management Question

Children who are characterized as unusually boisterous, aggressive, withdrawn, or destructive are often labeled "behaviorally disordered. " The term behavioral disorder is generally applied to children who have significant problems interacting with peers, teachers, parents, or others within their social environment. Identifying a behaviorally disordered child in the elementary classroorh can appear quite easy, for this broad classification has been assigned to those who practice behavior that is consistently contrary to the norms and expectations of peers and/or the teacher. There is much reason to question the accuracy of many such diagnoses and labels (Fremont & Wallbrown 1979). Growing evidence from the field of learning disabilities suggests that many children who have been called behavior problems are, in fact, children with social misperceptions (Fremont, Seifert, & Wilson 1977, Fremont, Wallbrown, & Nelson 1978, Wiig & Semel 1976). For example, if some youngsters can experience academic failure due to learning disability or perceptual deficits, it stands to reason that others can experience social problems resulting from faulty social perception. That is not to say that all academic learning disabled youngsters experience social perception difficulties, nor is it to say that all youngsters with social perception problems experience academic learning disability. Nevertheless, a significant number of social deviants experience faulty social perception that is responsible for their inappropriate display of social behaviors and/or faulty interpretation of the behaviors of others. Classroom teachers and school mental health specialists must be better equipped to determine which students who practice deviant behavior are behaviorally disordered and which students are experiencing faulty social perception.
Common characteristics of abused women.

The p u r p o s e o f t h i s s t u d y was t o i n v e s t i g a t e t h e p s y c h o l o g i c a l c h a r a c t e r i s t i c s o f women who r e m a i n i n a b a t t e r i n g r e l a t i o n s h i p f o r one o r more y e a r s . The C a t t e l l S i x t e e n P e r s o n a l i t y F a c t o r I n v e n t o r y was u s e d t o m e a s u r e t h e 16 s o u r c e t r a i t s w h i c h C a t t e l l f o r m e d t h r o u g h f a c t o r a n a l y s i s The q u e s t i o n n a i r e was a d m i n i s t e r e d t o a s a m p l e o f 11 b a t t e r e d women s e ­ l e c t e d f r o m t h o s e women who h a d s o u g h t a s s i s t a n c e f r o m t h e V i c t i m W i t n e s s A d v o c a t e P r o g r a m and f r o m women who r e s p o n d e d t o a n e w s p a p e r a d . The d a t a w e r e a n a l y z e d s t a t i s t i c a l l y . The mean r a w s c o r e s w e r e c a l c u l a t e d f o r e a c h o f t h e 16 f a c t o r s and t h e n c o m p a r e d t o t h e n o r m a t i v e means e s t a b l i s h e d f o r t h e g e n e r a l a d u l t p o p u l a t i o n . T v a l u e s w e r e c a l ­ c u l a t e d . S t a t i s t i c a l s i g n i f i c a n t r e s u l t s w e r e o b t a i n e d f o r F a c t o r A t o w a r d S i z o t h y m i a , F a c t o r B t o w a r d l e s s i n t e l l i g e n c e . F a c t o r F t o w a r d d e s u r g e n c y F a c t o r G t o w a r d s t r o n g e r s u p e r e g o s t r e n g t h and F a c t o r Q2 t o w a r d s e l f s u f f i c i e n c y . A s u b s t a n t i v e t r e n d was n o t e d f o r F a c t o r C t o w a r d l o w e r ego s t r e n g t h . The s t u d y s u g g e s t e d t h e p s y c h o l o g i c a l c h a r a c t e r i s t i c s o f t h e a b u s e d woman t o be r e s e r v e d , d e t a c h e d an d a l o o f and t h a t t h e women p o s ­ s e s s e d c h a r a c t e r i s t i c s o f s e l f s u f f i c i e n c y , p e r s i s t e n c e a n d m o r a l i s m . The women showed a d e c r e a s e i n i n t e l l e c t u a l f u n c t i o n i n g , h a d a low f r u s ­ t r a t i o n t o l e r a n c e and w e r e e m o t i o n a l l y l e s s s t a b l e . T h e s e t r e n d s a r e c o n c e p t u a l l y e x p l a i n e d w i t h i n t h e f r a m e w o r k o f C a t t e l l ! s P e r s o n a l i t y T h e o r y .
Collisionless absorption in sharp-edged plasmas.

The absorption of subpicosecond, obliquely incident laser light is studied using a 11/2D particle-in-cell code. Density scale lengths from {ital L}/{lambda}=0.01 to 2 and laser irradiances between {ital I}{lambda}{sup 2}=10{sup 14} and 10{sup 18} W cm{sup {minus}2} {mu}m{sup 2} are considered. Vacuum heating'' (F. Brunel, Phys. Rev. Lett. 59, 52 (1987)) dominates over resonance absorption for scale lengths {ital L}/{lambda}{lt}0.1, and is most efficient when {ital v}{sub osc}/{ital c}{congruent}3.1({ital L}/{lambda}){sup 2}. Absorbed energy is carried mainly by a superhot'' electron population with {ital U}{sub hot}{similar to}({ital I}{lambda}{sup 2}){sup 1/3--1/2}.
Regulatory Disorders in Israeli Infants: Epidemiologic Perspective

The concept of regulatory disorders has been clinically defined. However, epidemiologic validity has not yet been investigated. Children between the ages of 6 and 36 months ( N = 450) were included in the study. Two age groups were analyzed separately: 6 to 17 months (53%) and 18 to 36 months (47%). A specially designed questionnaire in Arabic and Hebrew pertaining to the physiologic and behavioral aspects of regulatory disorders was administered at the mother and child health clinics in northern Israel. It was established in the present study that a minimum of four regulatory items should be reported for the diagnosis of a regulatory disorder, as perceived by parents. Factor analysis revealed 6 and 10 different aggregates of regulatory items in the young and older age groups, respectively. The general prevalence of regulatory disorder as defined in the present study was found to be 18%. Age, maternal education, and sex were found to be significantly related to the prevalence of regulatory disorders. No difference in the prevalence of regulatory disorders between Arab and Jewish infants was found. Further validations of the concept of regulatory disorder as well as devising appropriate measurements in well-designed studies are warranted. (J Child Neurol 2003; 18: 748—754).
Molekulaarse kompleksdiagnostika olulisus suguteede infektsioonide diagnoosimisel

Taust. Molekulaarne kompleksdiagnostika voimaldab kliinilisest materjalist maarata palju erinevaid haigust tekitavaid mikroorganisme korraga. Eesmark. Selgitada senist suguteede infektsioonide diagnoosimise praktikat, kompleksuuringu moju selle kvaliteedile. Metoodika. Quattromed HTI laborisse uhe kuu jooksul saabunud suguteedest voetud proove (n = 4985) uuriti soltumata arsti tellimusest Luminexi xMAP-paneeliga suguteede infektsioonide selliste voimalike tekitajate suhtes nagu N. gonorrhoeae, C. trachomatis, C. trachomatis LGV, T. vaginalis, M. genitalium, M. hominis, U. urealyticum, U. parvum. Tulemused. Enamasti tellis arst uuringu uhe (31%), kahe (22%) voi kolme (20%) obligaatse voi oportunistliku patogeeni suhtes. Enim telliti C. trachomatis’e uuringut (91% proovidest). Uuritud proovidest leiti N. gonorrhoeae 0,2%-l, C. trachomatis 3,5%-l, T. vaginalis 0,5%-l, M. genitalium 1,2%-l, M. hominis 7,9%-l, U. urealyticum 7,7%-l ja U. parvum 32%-l juhtudest. Kasutatud meetodiga tuvastasime uuritud materjalis ka teisi STLI tekitajaid, mille suhtes arst ei olnud uuringut tellinud (sagedamini mitmeid STLI-d tekitavaid mikroorganisme, nt N. gonorrhoeae ja M. genitalium). Analuusides proove vaid arsti tellimuse jargi, oleks suguhaigusi pohjustavatest patogeenidest jaanud avastamata 40% N. gonorrhoeae, 0,6% C. trachomatis’e, 88% T. vaginalis’e ja 48% M. genitalium’i esinemisest. Jareldused. Kompleksdiagnostika kasutamine voimaldaks mitmete sugulisel teel levivate mikroorganismide (eelkoige N. gonorrhoeae ja T. vaginalis’e) paremat avastamist ning voiks seelabi parandada suguhaiguste ravi ja diagnoosimise kvaliteeti.Eesti Arst 2014; 93(8):450–455
The role of competing demands in the treatment provided primary care patients with major depression.

OBJECTIVE To examine whether competing demands explain the appearance of inadequate primary care depression treatment observed at a single visit. DESIGN A cross-sectional patient survey. PARTICIPANTS AND SETTING Two hundred forty patients with 5 or more symptoms of depression seeing 12 physicians in 6 primary care practices, representing 77.4% of the depressed patients identified through 2-stage screening of more than 11,000 primary care attenders. MAIN OUTCOME MEASURES In patients with elevated depressive symptoms, discussing depression as a possible diagnosis in untreated patients, and changing depression management in treated patients. RESULTS Physicians and patients discussed depression in 46 (47.9%) of 96 untreated patients; physicians changed depression treatment recommendations in 87 (60.4%) of 144 treated patients with current symptoms. Chronic physical comorbidity decreased the odds that physicians and untreated patients discussed depression as a possible diagnosis (odds ratio = 0.66, P = .01). New problems decreased the odds that treatment recommendations would be changed in treated patients who remained depressed (odds ratio = 0.39, P = .05). Physicians and untreated patients were more likely to discuss depression as a possible diagnosis if patients reported antidepressant medication was acceptable (odds ratio = 4.57, P = .01) and less likely to discuss depression if patients reported specialty care counseling was acceptable (odds ratio = 0.33, P = .05). CONCLUSIONS The attention depression gets during a given medical visit is less associated with the severity of the patient's depressive symptoms than with the number or recency of other problems the patient has. If competing demands provide ongoing barriers to depression treatment, interventions will be needed to assure that patients with chronic physical problems receive high-quality mental health care in the primary care setting.
Partial feedback linearizing control of ultracapacitor-based energy storage systems for grid-connected power system applications

This paper presents a nonlinear-controller design approach for ultracapacitor-based energy storage systems (UCESSs) for supplying active and reactive power in grid-connected power system applications. The controller is designed based on the dynamical model of UCESSs where the model is developed from the electrical equivalent circuit of the ultracapacitor (UC) connected to the grid through a voltage source converter (VSC). The nonlinear controller is designed based on the partial feedback linearization with an aim of controlling active and reactive power injected into the grid through the regulation of the respective currents. The stability analysis of the internal dynamics of UCESSs is also investigated in this paper as the controller cannot be implemented if these internal dynamics are unstable. The performance of the proposed controller is evaluated on a grid connected UC system and the simulation results show the superior performance of the proposed controller as compared to a finely-tuned PI controller.
Anemia as a complication of parvovirus b19 infection in renal transplant recipients.

BACKGROUND The frequency of B19 infection in renal transplant donors and recipients was studied to determine the significance of active viral infection in the development of anemia. MATERIAL AND METHODS Serum, plasma, and peripheral blood leukocyte samples of 47 renal transplant donors, 38 recipients with anemia (Group 1), and 25 without anemia (Group 2) after renal transplantation were evaluated for the presence of anti-B19 specific antibodies (ELISA) and B19 DNA (nPCR). RESULTS Active persistent B19 infection after renal transplantation was detected in 12 of the 38 in the Group 1 (10 had reactivation and 2 primary infection), and none of the recipients in the Group 2 had it. Of the 12 recipients in the Group 1, 10 were seropositive and 2 seronegative before renal transplantation; 10 received the transplants from the seropositive and 2 from seronegative donors. rHuEPO therapy-resistant severe anemia was detected only in the recipients with active B19 infection after renal transplantation in the Group 1 (7/12). The logistic regression analysis revealed a significant relationship between active B19 infection and severe anemia (OR, 0.039; 95% CI, 0.006-0.257; P=0.001). CONCLUSIONS Active B19 infection was documented only in the anemic recipients and could be associated with the development of severe anemia after renal transplantation. This allows us to recommend concurrent screening for viral DNA in plasma and detection of anti-B19 IgM class antibodies. To find the association between B19 infection and the development of anemia, further investigations are necessary.
PRIMARY RENAL LYMPHOMA

Primary renal lymphoma (PRL) is a rare disease. It is non-Hodgkin’s lymphoma of predominantly large cell type with a B-cell immunophenotype. Other histological types include follicular and small lymphocytic, plasmacytoid and small non-cleaved cell lymphoma. PRL usually affects adults and have slight male sex predilection; however, it has also been reported in children. PRL may present with pain, loss of appetite, nausea, heamaturia, weight loss, malaise, abdominal masses and renal failure. Both clinically and pathologically, PRL can be mistaken for carcinomas of the kidney or glomerulonephritis. Its treatment options include surgical excision, chemotherapy and radiotherapy. This study describes a 21-year-old female patient with bilateral PRL. The patient was referred to Department of Nephrology for evaluation of gradual onset of fever, weight loss, abdominal pain and abdominal masses. General examination revealed sick, emaciated, pale patient. Abdominal examination revealed palpable kidneys but no hepatosplenomegaly or lymphadenopathy. Laboratory findings included high serum creatinine (1290.6 mmol/L), blood urea nitrogen (59.9 mmol/L) and lactic dehydrogenase levels (1124) and negative tumour markers (human chorionic gonadotrophins, alphafetoprotein, CA and CA 19-9). Ultrasonography of the abdomen revealed enlargement of both kidneys (right kidney, 13.7 ¥ 8.5 and left kidney, 13.6 ¥ 6.0) with diffuse heterogeneous echogenisity, loss of cortico-medullary differentiation and multiple hypo-echoic areas. Spleen, liver and gallbladder were unremarkable. Computed tomography revealed bulky kidneys with mildly lobulated outline, marked decrease in the excreting function and multiple isodense solid nodular foci. Extensive investigations did not identify primary tumours or lymph node enlargement elsewhere. Computed tomography-guided biopsy specimens were obtained from the renal lesions and were submitted for histological examination (Fig. 1A). Histological examination revealed a diffuse growth pattern of centroblasts (pale or basophilic cytoplasm, vesicular chromatin due to chromatin margination, two to three nucleoli, often near membrane). Glomeruli and other structures were left intact. The tumour cells showed positive staining for CD19, CD20, CD22, CD45 and CD79a and negative staining for TdT, CEA, EMA and cytokeratin (Fig. 1B–D). The diagnosis of primary renal non-Hodgkin high-grade lymphoma, diffuse large B-cell type was established. The patient started treatment of non-Hodgkin’s lymphoma chemotherapy (vincristin, adriamycin,
Exoskeleton for human upper-limb motion support

We have been developing exoskeletons (exoskeletal robots) for assisting the motion of physically weak persons such as elderly persons or slightly disabled persons in daily life. In this paper, we propose a 3 DOF exoskeleton and its control system to assist the human upper-limb motion (shoulder joint motion and elbow joint motion) of physically weak persons. The proposed robot automatically assists the human motion mainly based on the skin surface electromyogram (EMG) signals. Fuzzy control has been applied to realize the sophisticated real-time control of the exoskeleton. Experiment has been performed to evaluate the proposed exoskeleton.
Obsessive compulsive disorder, depression, and fluoxetine.

BACKGROUND Fluoxetine, a selective serotonin reuptake blocker, is an antidepressant medication that has also been shown in open clinical trials and one controlled trial to be effective in the treatment of obsessive compulsive disorder (OCD). OCD is often complicated by depression, and depressive symptoms may interfere with response to both pharmacologic and behavioral treatments. METHOD We describe pilot data from 10 outpatients who met DSM-III-R criteria for OCD in whom the possibility of a depressive reaction or lack of antidepressant response occurred during an open trial of fluoxetine. RESULTS Rapid increase in fluoxetine dose to high doses was associated with depressive symptoms in 6 patients. In 8 patients, improvement in depression was associated with addition of a tricyclic antidepressant to fluoxetine treatment. In 5 patients, both OCD and depressive symptoms improved when the patient was switched to the partially selective serotonin reuptake blocker clomipramine. CONCLUSION This paper serves to alert clinicians to the possibility of a depressive reaction, or lack of antidepressant response, to fluoxetine in OCD patients. This possibility can only be resolved scientifically by adequately controlled experimental trials. If depression occurs, combined fluoxetine and tricyclic treatment, or a switch to a partially selective serotonin reuptake inhibitor, may be helpful. Special considerations and side effects of combined fluoxetine-tricyclic treatment are described.
Delegation with buy-back contract in a fashion supply chain under demand uncertainty

We consider a three-tier supply chain with an original equipment manufacturer (OEM, the fashion brand), a contract manufacturer (CM), and a material supplier. There exist two typical outsource structures: control and delegation, where control refers to that the OEM only outsources products production to the CM, while delegation refers to that the OEM outsources both products production and materials procurement to the CM. Under delegation, buy-back contract is commonly adopted, where the OEM can return the unsold products to the CM at the end of selling season, shifting part of overstock risk to the CM. We find that with wholesale price, control is always more beneficial than delegation to the OEM. However, delegation with buy-back contract might benefit the OEM. We identify a demand enlargement effect, a wholesale complementary effect and a wholesale substitution effect of the buy-back price. We find that these three effects influence the OEM's preference over control and delegation. We further study the impact of demand uncertainty on the OEM's preference. We find that when demand uncertainty is relatively high and buy-back price is moderate, delegation dominates control.
Premedication with antihistamines may enhance efficacy of specific-allergen immunotherapy.

BACKGROUND Antihistamine premedication has been used to increase safety of specific-allergen immunotherapy. Its influence on the efficacy of this treatment has not been studied so far. OBJECTIVE The goal was to analyze the influence of antihistamine premedication on long-term efficacy of specific-allergen immunotherapy. METHOD Patients included in a double-blind, placebo controlled trial who received premedication with terfenadine or placebo during initial rush immunotherapy with honeybee venom in 1988/1989 were assessed in a retrospective analysis for the long-term protective effect, as indicated by the tolerance of a bee sting challenge or field sting during immunotherapy. RESULTS Of the 52 patients who had participated in the 1988/1989 trial, 47 could be reassessed after an average of 3 years. Of these, 45 were still receiving bee venom immunotherapy. A total of 41 patients were stung by bees while receiving immunotherapy (20 of the terfenadine-premedicated group and 21 of the placebo-premedicated group), 17 with in-field stings and 24 with in-hospital sting challenge. Six (29%) of the patients receiving placebo had a mild-to-moderate systemic allergic reaction, whereas none of the patients receiving terfenadine reacted to the bee sting (P =.012). CONCLUSIONS These results indicate that antihistamine premedication during the initial phase of specific-allergen immunotherapy may enhance the efficacy of this treatment.
A QSAR evaluation of glucocorticoid receptor binding

Exposures to environmental concentrations of endocrine disrupting compounds are now a known threat to both human and ecological health. In the current study capabilities for structure-activity modeling incorporated in the platform QSAR Toolbox were employed for investigation the binding effect of set of chemicals toward glucocorticoid receptor. A total of 39 steroidal ligands were split in categories, representing strong, moderate and weak binders. As a result of comparative analysis a mechanistic reasonable molecular descriptors were found to be useful for prediction of strong and moderate receptor binders. It was found that the important feature related to strong binders is their surface which is assessed by specific range of van der Waals surface area. Regarding moderate binders it was found that the interaction can be assessed by using more specific descriptor van der Waals partial negative surface area. The obtained results suggest that identified descriptors and their specific ranges are reliable and can be used as preliminary in silico evaluation in identification of potential glucocorticoid binders.
The Stressors and Coping Strategies of Older Adults With Persistent Atrial Fibrillation Prior to and Following Direct Current Cardioversion

Objective:The purpose of this study was to explore the stressors and coping strategies of older adults with persistent atrial fibrillation (AF) before and after direct current cardioversion. Method: The study used a qualitative descriptive design. Sixteen patients were recruited through an AF clinic to participate in individual interviews prior to the cardioversion and at 6 and 12 weeks post procedure. Results: Pre-cardioversion, older adults experienced symptom and health care–related stressors superimposed on existing non-AF stressors. They used a range of emotion and problem-focused coping. Non-AF stressors increased post procedure at the same time that participants perceived less need for coping strategies with a return to regular rhythm. Discussion: There was a shift from AF to non-AF related stressors following the cardioversion but a decrease in coping strategies. Older adults with AF should be encouraged to maintain use of coping strategies to manage ongoing stress and reduce the risk of AF recurrence.