Miracle-dz/UniFAR-FTUs huggingface dataset:
From the origin to the present : the history of sports and exercise medicine

The dawn of sports and exercise medicine (SEM) dates back more than one century, when the first medical investigations on trained or untrained individuals were collected in the Sports Laboratory in Dresden, Germany, managed by Arthur Mallwitz, during the 1st International Hygiene Exhibition, from May to October 1911. One year later the 1st Congress for the scientific investigation of Sports and Physical Exercises was held in Oberhof, Germany, with topics about the physical education, woman and physical fitness, cardiovascular adaptations to the training and doping. The first SEM Association was founded during this meeting and it was called the “German Committee for Scientific Investigation of Sports and Physical Exercises”. After the First World War, in 1928 the first “Association Internationale Médico-Sportive” (AIMS) was founded in St. Moritz, Switzerland, during the 2nd Winter Olympic Games. The purposes of the AIMS were to protect the athlete’s health and to develop the sciences and the studies concerning sport and exercise. In 1934 the AIMS became “Fédération Internationale de Médecine Sportive” (FIMS) and, subsequently in 1998, “Fédération Internationale de Médecine du Sport” (Tittel and Wesseling, 2005). In the last decade the network of FIMS has been considerably expanded: in the year 2016, 118 nations belonged to the International Federation of Sports Medicine (FIMS) and thanks to the realization of the FIMS Collaborating Centres of Sports Medicine (CCSM) project, 24 Centres have been already accredited worldwide functioning as local ambassadors of FIMS ́ vision and mission, helping to achieve our shared objectives in all parts of the world. To this respect, one of the most important milestones has undoubtedly been the establishment of the FIMS Headquarters at the Maison du Sport Internationale in Lausanne, Switzerland a return to the roots where FIMS was founded. The aims of the International Federation of Sports Medicine can actually be summarized as follows: Vision • Caring for the athletes and sports communities. • Leading education and science in sports medicine worldwide. • Promote ethics in sports and medicine.
Effects of myofascial self-release. Systematic review

Introducción: la autoliberación miofascial (ALM) es una intervención realizada para mejorar la movilidad de las fascias musculares, utilizada como complemento durante el calentamiento o la vuelta a la calma de un entrenamiento deportivo. Objetivo: evaluar la evidencia existente en la bibliografía sobre este tipo de técnicas y sus efectos reales encontrados. Métodos: se realizó una búsqueda bibliográfica en las bases de datos electrónicas Pubmed, ScienceDirect, SportDiscus y Scopus, incluyendo artículos hasta mayo de 2016. Las palabras de búsqueda utilizadas fueron "foam roller", "foam rolling", "self-myofascial", "effects" y "range of motion". Se establecieron cuatro grupos de criterios de inclusión. Resultados: 11 artículos fueron incluidos. La ALM parece tener efectos a corto plazo sobre el rango de movimiento, sin afectar al rendimiento muscular y favoreciendo la recuperación y disminuyendo la aparición de dolor muscular de aparición tardía. Conclusiones: la técnica de ALM es novedosa y de reciente aplicación en el ámbito deportivo, aunque existe escasa evidencia sobre su método de aplicación debido a la heterogeneidad de los métodos utilizados.
The Role of Periodontal Disease in Etiology of Myocardial Infarction

Periodontal disease is a chronic inflammatory disease of periodontium and its advanced form is characterized by periodontal ligament loss and destruction of surrounding alveolar bone. Cardiovascular diseases are the most common cause of adult death in the world. Over 80% of cardiovascular disease deaths take place in low-and middleincome countries and occur almost equally in men and women. The main causes of cardiovascular diseases are tobacco use, unhealthy diet, physical inactivity, high blood pressure and high blood cholesterol. The association of coronary heart disease and periodontal disease may be due to an underlying response trait, which places an individual at high risk for developing both periodontal disease and atherosclerosis. It was suggested that periodontal disease, once established provides a biological burden of endotoxin and inflammatory cytokines, especially thromboxane A2, prostaglandin E2, interleukin (IL) 1L=1 α, and tumor necrosis factor-β, which serve to initiate and exacerbate atherogenesis and thromboembolic events. As we known dental infection especially periodontal disease can be tightly connected with cardiovascular disease, that’s the reason why patients who have valvular defect or some other congenital defects such as septal defects, or who have prosthetic valve, should receive antibiotic therapy as prophylaxis before any blood included procedure. It is very important to prevent periodontal disease, or if it’s already present, the treatment should commence as soon as possible to prevent the risk factors from occurring and causing cardiovascular disease.
Analysis of non-stationary random vibration environment of industrial robot based on EMD and PNN

Aiming at the characteristic of frequency density of non-stationary random vibration signals of industrial robots during machining, a multi-component process neural network (PNN) auto-regressive model was proposed based on empirical mode decomposition (EMD). First, the original time series were decomposed into intrinsic mode functions (IMF) of different scales by EMD. Then, the time-varying parameters of each IMF were analyzed by PNN and the time-varying power spectral density was determined. Finally, the time-varying independent power spectral density of all components is reconstructed by linear superposition as the time-varying independent power spectral density of the original signal. The calculation results show that the frequency resolution performance of this method is better than that of traditional analysis method.
What do we mean by the directions “cranial” and “caudal” on a vertebra?

In illustrating vertebrae, it is important to consistently depict their orientation, so we can objectively assess and compare the slope of the neural arch, neural canal, or articular surfaces. However, differing vertebral shapes across taxa and across regions of the spinal column make it difficult to maintain consistency, or even define what we mean by the directions “cranial” and “caudal”. Consequently, characters such as “Neural arch slopes cranially 30° relative to the vertical” are disputable rather than objective measurements. Cranial and caudal are defined as directed along the horizontal axis, but several different notions of “horizontal” are possible: 1. Long axis of centrum is horizontal. This is appealing for elongate vertebrae such as sauropod cervicals, but is not always well defined, and is difficult to determine for craniocaudally short vertebrae such as most caudals. 2. Articular surfaces of centrum are vertical. Difficult to determine when dealing with facets that are concave or (worse) convex; and ambiguous for “keystoned” vertebrae in which the facets are not parallel. 3. Neural canal is horizontal. Anatomically informative, but difficult to determine in vertebrae that have not been fully prepared or CT-scanned, and impossible to see in lateral view. Ambiguous for vertebrae where the dorsal and ventral margins of the canal are not straight or not parallel. 4. Similarity in articulation (“horizontal” is defined as a line joining the same point on two similarly oriented copies of the same vertebra when optimally articulated). This is less intuitive than definitions 1–3, but takes the entire vertebra into account. We advocate explicitly stating a definition and using it consistently. In most cases, definition 3 (“Neural canal is horizontal”) best reflects anatomical and developmental realities, and it is therefore preferred. Low-tech techniques can be used to determine neural canal orientation with adequate precision for most purposes.
A chromosomal breakage syndrome with profound immunodeficiency

The chromosomal breakage syndromes--ataxia-telangiectasia, Fanconi9s anemia, and Bloom9s syndrome--are associated with growth failure, neurologic abnormalities, immunodeficiency, and an increased incidence of malignancy. The relationship between these features is unknown. We recently evaluated a 21-year-old female with more severe chromosomal breakage, immunodeficiency, and growth failure than in any of the mentioned disorders. As of November 1985, the patient remains clinically free of malignancy. At age 18, the patient9s weight was 22.6 kg (50th percentile for seven years), height was 129 cm (50th percentile for eight years), and head circumference was 42 cm (50th percentile for six months). Laboratory studies demonstrated a marked decrease in both B and T cell number and function. The peripheral blood contained 400 to 900 lymphocytes/microL with 32% T11 cells, 17% T4 cells, and 21% T8 cells. The proliferative responses to phytohemagglutinin (PHA), pokeweed mitogen, and concanavalin A were less than 10% of control. There were 1% surface IgM positive cells, and serum IgG was 185 mg/dL, IgM 7 mg/dL, IgA 5 mg/dL. In lymphocyte cultures stimulated with the T cell mitogens PHA, phorbol ester, and interleukin 2, 55% of the banded metaphases demonstrated breaks or rearrangements. The majority of the breaks involved four fragile sites on chromosomes 7 and 14, 7p13, 7q35, 14q11, and 14q32. These are the sites of the genes for the T cell-antigen receptor and the immunoglobulin heavy chain and are sites of gene rearrangement in lymphocyte differentiation. Epstein-Barr virus stimulated B cells and fibroblast cultures also demonstrated a high incidence of breaks, but the sites were less selective. These findings suggest that the sites of chromosomal fragility in the chromosomal breakage syndromes may be informative and that factors other than the severity of the immunodeficiency or the high incidence of chromosomal damage may contribute to the occurrence of malignancy in the chromosomal breakage syndromes.
Psychopharmaka-induzierte unerwünschte Wirkungen in der Ernährungstherapie

Zusammenfassung Metabolische Effekte von Psychopharmaka sind sehr häufig – dies gilt insbesondere für appetitsteigernde Wirkungen und die Zunahme von Körpergewicht. Besonders stark mit einer Gewichtszunahme assoziiert sind Antipsychotika (Neuroleptika) und einige Antidepressiva (Mirtazapin, Lithium, Trizyklika). Resultierende metabolische Veränderungen sind häufig klinisch relevant, da sie sich negativ auf die kardiovaskuläre Morbidität und Mortalität auswirken können. Insbesondere bei Patienten unter Therapie mit Antipsychotika sollten regelmäßig Kontrolluntersuchungen durchgeführt werden (Körpergewicht, Blutdruck, Blutzuckerspiegel, Cholesterin, Leber-/Nierenfunktion). Wirkstoffspezifische metabolische Nebenwirkungen können antizipiert und durch geeignete Ernährungs- und Verhaltensinterventionen abgemildert oder verhindert werden. Alternativ sollte ärztlicherseits auch ein Wirkstoffwechsel erwogen werden, falls die Nebenwirkungen die Lebensqualität des Patienten relevant beeinträchtigen. Bei Unwirksamkeit anderer Maßnahmen zur Gewichtskontrolle kann die Anwendung von Orlistat bzw. Metformin (off-label) versucht werden.
Poster: Design of AI-Powered Augmented Reality Games for Autistic Children

Autism Spectrum Disorder (ASD) emerges as a significant medical challenge. It is highly costly to deliver effective treatment to children with ASD, especially the low-functioning ones. This study aims to develop a low-cost, portable, and engaging gaming system based on emerging technologies such as augmented reality (AR) and artificial intelligence (AI) to efficiently deploy customized training based on the needs of ASD children through HoloLens. We first present the design of the AR-based gaming system and then describe two types of therapy most commonly used in Autism clinical practice to enhance patients’ attentiveness and imagination. Finally, we identify a set of challenges faced to develop games that are lightweight, user-friendly, intelligent, customized, encouraging, high-responsive, and secure.
Play Experiences of Children With a High Level of Physical Disability.

IMPORTANCE This research provides practitioners with an understanding of play from the perspective of children with a high level of physical disability. OBJECTIVE To explore the experience of play for children who have a high level of physical disability as a result of cerebral palsy. DESIGN Interpretative phenomenological analysis. Children participated in three interviews each to discuss their experience of play. Visual methods, such as use of video and drawings, enabled a greater depth of discussion. SETTING Participants' homes. Participant : Six children ages 6-11 yr with a high level of physical disability, recruited via snowball sampling and charities working with children with cerebral palsy. RESULTS We found that making choices and controlling play were important for the children, that they often experienced play differently than their peers, and that they connected with others in play through humor and communication skills. CONCLUSIONS AND RELEVANCE Occupational therapy practitioners can respond to the findings by understanding the embodied unit, recognizing vista play, enabling expression of each child's imagined self, supporting negotiation of identity and disability, recognizing participation in play through watching, enabling opportunities for belonging, enabling development of component skills for play, and supporting strategies for connection. WHAT THIS ARTICLE ADDS This article provides occupational therapy practitioners and other professionals with an understanding of play from the perspective of children who have a high level of physical disability.
Features of Food Hypersensitivity in Children with Autism Spectrum Disorder

Currently, the incidence of autism spectrum disorders (ASD) continues to increase in the children’s population. However, the pathogenesis of autism remains controversial.The purpose of this work is to evaluate the performance of the elimination nutritional approaches to the dynamics of indicators of food hypersensitivity, the balance of interleukins and psychophysiological parameters in children with ASD.Methods. A prospective cohort study of children aged 7 ± 2 years, healthy and diagnosed with ASD was performed. Determination of specific immunoglobulin concentrations to 111 food antigens and interleukins was measured by ELISA. Psychophysiological indicators of communicative competence in children with ASD were evaluated in the ATEC-test.Results. It was established that in children with ASD (n = 69), the frequency of occurrence of food hypersensitivity and indicators of specific sIgG concentrations to food antigens of dairy and grain products are higher (р < 0.05). A direct correlation was found between the concentration of INFγ, IgG concentrations to antigens of dairy, grain products and C. albicans. High ratios of the INFγ/IL4 and INFγ/IL10 ratios (p < 0.05) were revealed. As a result of compliance with the elimination diet was noted significant decrease in the concentration of sIgG to food antigens, sIgG to C. albicans, changes indicators following the results of ATEC testing.The data obtained revealed the unexplored effects the influence of specific food hypersensitivity on the process of initiation and maintenance of immune inflammation, as well as on the communicative competence in pathological conditions. A personalized elimination diet can improve the immunorehabilitation and the quality of life of children with autism.
The impact of persistent milk consumption in the pathogenesis of type 2 diabetes mellitus

Background: Milk and sugar are excessively consumed in a Western diet. There is increasing epidemiological evidence that the intake of unfermented pasteurized cow´s milk is associated with an increased risk of type 2 diabetes mellitus (T2D). It is the intention of this review to provide translational biochemical evidence for milk´s diabetogenic mode of action. Milk proteins provide the highest amounts of branched-chain amino acids (BCAAs) and thus contribute to total BCAA intake, which enhances BCAA plasma levels associated with increased risk of T2D. The consumption of pasteurized milk raises plasma levels of miRNA-29b, which is a diabetogenic miRNA promoting insulin resistance (IR). miRNA29b inhibits the activity of branched-chain-keta acid dehydrogenase, the rate limiting enzyme of BCAA catabolism, which is impaired in patients with IR and T2D. Milk consumption stimulates mTORC1 activity and increases insulin synthesis. -cell mTORC1 is overactivated in T2D patients resulting in impaired autophagy which enhances endoplasmic reticulum (ER) stress associated with a greater risk of early -cell apoptosis, the pathogenic hallmark of T2D. Chronic insulinotropic action of milk-derived BCAAs, IR-promoting mTORC1 overactivity, and miRNA-29b signaling combined with excessive glucose-mediated insulin secretion overburden -cell insulin homeostasis. Epidemiological and translational evidence identifies continued milk intake as a promoter of T2D, the most common metabolic disease of Western civilization. Keywords: Branched-chain amino acids, branched-chain-keto acid dehydrogenase, diabetes mellitus type 2, insulin resistance, milk, miRNA-29b, mechanistic target of rapamycin complex 1.
Object detection with smart glasses

This paper presents a software system integration to augmented reality smart glasses. The software system is created using mechanisms and insights from deep learning, computer vision and neural networks. An object recognition model is integrated into the software system, which is the basis for the further creation of an intelligent system for discovering pre-selected and prepared information about the objects around us.
Evaluation of image quality and radiation dose in low tube voltage coronary computed tomography angiography

BACKGROUND Coronary computed tomography angiography (CCTA) is an important modality in diagnosis of coronary artery disease (CAD). Owing to the fact that computed tomography (CT) examinations are performed using ionizing radiation; applying radiation dose-reduction strategies seems to be necessary. Lowering tube voltage (in kV) according to the patient’s body mass index (BMI) or weight is an approach that is investigated by many researchers. The goal of this study was to evaluate the impact of low tube voltage CCTA on radiation dose and image quality in order to decrease radiation dose in selected patients who meet inclusion criteria of the introduced protocol. METHODS Patients with clinical indications of CCTA who met inclusion criteria were classified in two groups randomly. Imaging of two groups was performed using 120 kV and 100 kV, respectively. Subjective and objective parameters of image quality and radiation dose of two groups were measured. Afterward, data were analyzed by appropriate statistical tests using SPSS software. RESULTS While differences in image quality between two groups were not significant, radiation dose of patients who underwent 100 kV CCTA was significantly lower than the other group. Effective doses (EDs) of first and second groups were 22.30 ± 5.48 mSv and 13.82 ± 2.00 mSv, respectively (P < 0.001). CONCLUSION Lowering tube voltage in non-obese patients is an effective and practical approach to radiation dose reduction without missing image quality that should be considered especially for female patients.
A Team-Based Approach to Care in a Primary Care Community Clinic

Implementation Lessons) The use of high-functioning clinical teams in healthcare, particularly in the primary care setting, has been shown to be associated with many improvements in outcomes for patients and providers (Ladden et al., 2013; Reckrey, et al., 2015; Misra-Hebert et al., 2015; Goldberg et al., 2013). A student from a doctor of nursing practice program was the principle investigator (PI) who designed and implemented a practice improvement project with the providers, receptionist, and nurse volunteer at an urban community clinic serving low-income patients. The practice improvement project to change practice within the clinic to include the use of an altered team structure by adding a documentation scribe. The overall project outcomes were that the addition of a scribe did not impact patient wait times, but did lead to shorter appointment lengths. There were four different providers involved in this project, who all expressed that the addition of a scribe was valuable to practice; providers were able to devote more uninterrupted face-to-face time to patients during appointments, and the inclusion of a scribe reduced the time required to complete chart notes following patient appointments, as was previously required for providers in the clinic. A nurse volunteer worked as the scribe during this practice change project, which did not have an associated monetary cost, as a benefit for the clinic. Background Utilization of high-functioning teams in clinical settings demonstrates improved outcomes for patients and team members. High-functioning teams are characterized by members who share goals and knowledge, and who demonstrate mutual respect and high-quality communication that is timely, frequent, and accurate with a problem-solving focus (Cromp, Coleman, Liss, Ross, & Trehearne, 2015). A team-based approach to primary care practice is
Alzheimer's Disease and Diabetes: A Transgenic Mouse Model in Behavior, MRI, and Cells

Alzheimer’s Disease and Diabetes: A Transgenic Mouse Model in Behavior, MRI, and Cells Kevin Sage Steed Neuroscience Center, BYU Doctor of Philosophy Alzheimer’s disease (AD) is the most common form of dementia, afflicting almost 5 million patients in the US, and impacting millions more, financially, physically and emotionally. Coming in as the 6th leading cause of death in the US, and showing no signs of slowing its annually increasing rates, the world is in desperate need of improved understanding of the disease’s multifaceted pathogenesis and progression, more accurate forms of detection and diagnosis, and more effective prevention and treatment. While many are focused on the noble pursuit of understanding the genetic contributions to the appearance of the pathological amyloid beta (Aβ) plaques and tau tangles seen in AD, the majority of cases are not explained by genes or allele risk. Instead environmental, dietary and lifestyle contributors may be the key to understanding, diagnosing and treating this awful disease. Diet especially may impact the body’s ability to regulate oxidative stress, which will cause damage within the cell and lead to further dysregulation of iron storage and metabolism. Iron storage is heavily monitored through cellular mechanisms, and the way in which the body reacts involves creation of the Aβ plaques and tau tangles as receptacles for the molecule it has deemed as the cause of the problem, iron. We have aptly named our theory, the Iron Hypothesis, and in the following document will outline the evidence for this hypothesis, and the experiments designed and performed to prove it. First, we aimed to examine the impacts that various treatments would have on a transgenic in-vivo model, examining the cohorts’ behavior over several time points. We report a significant difference in the behavioral measures of time, distance, errors and failed trials in the radial arm maze existed between genotype, treatment and sex of the mice. Tissue of the experimental mice was collected, but will be processed and analyzed at a later date. Secondly, we aimed to examine the same cohorts of the in-vivo mouse model for minute anatomical changes that took place over the course of the aforementioned behavioral trials using novel MRI scanning sequences sensitive to the low levels of iron build up. We report significant differences in the UTE scan measures for our western diet treatment at TE’s of 1.2ms. Additionally, further investigation and optimization of the protocol may be required to further expand the findings.