Miracle-dz/UniFAR-FTUs huggingface dataset:
Strategic entrepreneurship: entrepreneurial strategies for wealth creation

Entrepreneurship involves identifying and exploiting entrepreneurial opportunities. However, to create the most value entrepreneurial firms also need to act strategically. This calls for an integration of entrepreneurial and strategic thinking. We explore this strategic entrepreneurship in several important organizational domains to include external networks and alliances, resources and organizational learning, innovation and internationalization. The research in this special issue examines both traditional (e.g., contingency theory, strategic fit) and new theory (e.g., cultural entrepreneurship, business model drivers). The research also integrates, extends, and tests theory and research from entrepreneurship and strategic management in new ways such as creative destruction (discontinuities), resource-based view, organizational learning, network theory, transaction costs and institutional theory. The research presented herein provides a basis for future research on strategic entrepreneurship for wealth creation. Copyright © 2001 John Wiley & Sons, Ltd.
Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys

Capsid decoys enhance the efficacy of AAV vector transduction after systemic delivery in the presence of neutralizing antibodies. A Slight of Hand for Gene Therapy Gene therapy has been quite successful—in animal models. But when it comes to translating gene therapy to humans, there have only been a few shining successes. One limiting factor has been the vectors used. Adeno-associated virus (AAV) vectors are safe, noninvasive, and potentially effective; however, people who have been previously exposed to AAV have preexisting neutralizing antibodies that block gene delivery. Now, Mingozzi et al. trick these antibodies into binding empty viral capsid, overcoming their inhibitory effects. The authors hypothesized that introducing empty capsids along with the gene therapy vector would titrate out the neutralizing antibody response to AAV, allowing for successful gene therapy even in the presence of preexisting neutralizing antibodies. They found that varying the ratio of empty capsid to gene therapy vector could successfully inhibit the neutralizing antibody response in both human serum and a mouse model by serving as a decoy for antibody binding. The authors then mutated the receptor binding site of their capsid so that it could bind the neutralizing antibody but not target cells, further increasing the safety profile of this approach. These capsid decoys worked in a dose-dependent manner and were successful even with high antibody titers. What’s more, they were safe and effective in rhesus macaques. Although this approach remains to be tested in humans, tricking neutralizing antibodies with decoys may be the next step in advancing gene therapy in the clinic. Adeno-associated virus (AAV) vectors delivered through the systemic circulation successfully transduce various target tissues in animal models. However, similar attempts in humans have been hampered by the high prevalence of neutralizing antibodies to AAV, which completely block vector transduction. We show in both mouse and nonhuman primate models that addition of empty capsid to the final vector formulation can, in a dose-dependent manner, adsorb these antibodies, even at high titers, thus overcoming their inhibitory effect. To further enhance the safety of the approach, we mutated the receptor binding site of AAV2 to generate an empty capsid mutant that can adsorb antibodies but cannot enter a target cell. Our work suggests that optimizing the ratio of full/empty capsids in the final formulation of vector, based on a patient’s anti-AAV titers, will maximize the efficacy of gene transfer after systemic vector delivery.
Iron Deficiency Aneamia is Moderate Public Health Problem among School Going Adolescent Girls in Berahle District, Afar, Northeast Ethiopia

Introduction: Anemia among reproductive age group women in Ethiopia is moderate public health problem. However, the prevalence of anemia among school going adolescent girls is not well documented yet. Objective: To determine the magnitude of anemia and associated factors among school going adolescent girls in Berahle district, Afar, northeast Ethiopia. Methodology: Institutional based cross-sectional study design was employed. Multi-stage sampling technique was used: In first stage schools were selected randomly, in the second stage in the selected schools, 338 school going adolescent girls (age 14-19 years old) were selected systematically. Structured questionnaires was used to collect Socio-demographic, socio-economic, dietary pattern and frequency of study participants. After collecting the Blood sample, Hemocue haemoglobin spectrophotometer (Hemocue HB 301 analyzer) was used to analysis hemoglobin concentration. SPSS version16.1 statistical software was used to enter and analysis the data. Bivariate and multivariate logistic regressions were used to test association among dependant and independent variables. For all statistical tests, significance level was set at p-value of 0.05 and confidence interval of 95%. Result: Around one-fourth (22.8%) of school going adolescent girls were anemic. Low Scio Economic States, AOR 2.8 (CI: 1.1, 3.7), not consuming egg AOR 2.4 (CI: 1.3, 4.3), milk consumption AOR 7.2(CI: 2.9, 17.6), not consumption of vegetables AOR 2.5 (CI: 1.3, 4.9) and meat AOR 2.4 (CI: 1.24, 4.67) were the significant causes for aneamia. Conclusion: Anemia among school going adolescent girls was moderate public health problem and Low Scio-economic States, low consumption of egg, meat and other vegetables and high consumption of milk were the significant causes for anemia.
Kwafina: Internationalization plan

This Work Project develops a possible suggestion of how and where Kwafina, an Angolan firm, should internationalize to the European food market. The proposed methodology is used for identifying potential foreign markets and to identify the entry mode that best fits the firm’s strategy. Screening, identification, and selection characterize the three stages in the evaluation of potential foreign markets and the identification of possible entry modes are based on the proposed theoretical framework.
Environmental Policy, Company Environment Protection, and Stock Market Performance: Evidence from China

This paper studies the impact of environmental protection efforts on the market values of firms using the carbon emission rights trading scheme (CERTS) in China as an exogenous shock. We find that (1) the environmental policy of CERTS increases the market values of firms in the environment industry, (2) the efforts of firms on environmental protection further enhance their market values, and (3) the market values of firms located in the regions with CERTS are further improved. Our findings suggest that firms in the environment industry could improve their market values and obtain benefits by strengthening their environmental protection activities. We offer an important policy implication that the government should enact appropriate policies to improve the activities of firms on environmental protection and the sustainable development of the economy. Copyright © 2012 John Wiley & Sons, Ltd and ERP Environment.
Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling.

ESCs (embryonic stem cells) are derived from the inner cell mass of pre-implantation embryos and are pluripotent, meaning they can differentiate into all of the cells that make up the adult organism. This property of pluripotency makes ESCs attractive as a model system for studying early development and for the generation of specific cell types for use in regenerative medicine and drug screening. In order to harness their potential, the molecular mechanisms regulating ESC pluripotency, proliferation and differentiation (i.e. cell fate) need to be understood so that pluripotency can be maintained during expansion, while differentiation to specific lineages can be induced accurately when required. The present review focuses on the potential roles that PI3K (phosphoinositide 3-kinase) and GSK-3 (glycogen synthase kinase 3)-dependent signalling play in the co-ordination and integration of mouse ESC pluripotency and proliferation and contrast this with our understanding of their functions in human ESCs.
Cultured fetal rat myoblasts release peptide growth factors which are immunologically and biologically similar to somatomedin

The production of immunologically and biologically active somatomedin activity from isolated myoblasts and fibroblasts from fetal rats of 21 days gestational age was investigated. Myoblast‐rich cell populations were derived from primary cultures of dispersed muscle cells by the tendency of myoblasts to become detached from the culture dish in the presence of cytochalasin B. Fibroblasts were obtained from fetal muscle. Culture medium conditioned by exposure to myoblasts for 48 hours produced an increased incorporation of both [35S]sulphate and [3H]thymidine by explants of fetal rat costal cartilage in vitro compared to fresh medium. Myoblast‐conditioned medium also contained somatomedin‐C‐like immunoreactivity which diluted in parallel with partially purified human somatomedin‐C (3,271 ± 446 mU/mg cell protein; mean ± SEM, seven experiments). Medium conditioned by exposure to fetal rat fibroblasts did not promote isotope uptake by fetal rat cartilage above control values, and contained only low levels of somatomedin‐C‐like immunoreactivity (343 ± 89 mU/mg cell protein, three experiments). The release of both somatomedin bioactivity and immunoreactivity into conditioned medium was significantly reduced by the incubation of myoblasts in the presence of rat growth hormone (100 ng/ml and 500 ng/ml). We conclude that fetal rat myoblasts released growth factor activity during culture which exhibited biological and immunologic characteristics of somatomedin. Since the bioactivity was demonstrated on skeletal tissues from rat fetuses of the same gestational age as those that yielded myoblasts such growth factor release may be physiological.
A Reexamination of the Determinants of Consumer Satisfaction

Although the “disconfirmation of expectations” model continues to dominate research and managerial practice, several limitations indicate that it is not a complete picture of satisfaction formation. The authors propose a new model of the satisfaction formation process that builds on the disconfirmation paradigm by specifying a more comprehensive model that includes two standards in a single model and specifically incorporates the impact of marketing communication. An empirical test of the model provides support for the hypothesized relationships and a better understanding of the mechanisms that produce satisfaction.
Lack of correlation between cerebral vasomotor reactivity and dynamic cerebral autoregulation during stepwise increases in inspired CO 2 concentration

Sung-Moon Jeong, Seon-Ok Kim, Darren S. DeLorey, Tony G. Babb, Benjamin D. Levine, and Rong Zhang Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center, Dallas, Texas; Department of Anesthesiology and Pain Medicine, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea; Department of Clinical Epidemiology and Biostatistics, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea; and Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada
Environmental factors independently associated with the first episode of wheezing among children

30-yr-old patient who was treated with isotretinoin for 3 months (5). The third report describes the successful treatment of acne vulgaris in a 13-yr-old patient who was treated with isotretinoin for 5 months (6). In none of the reports, the authors provide information on the concentration of itraconazole in blood of their patients while on comedication with isotretinoin, so we suspect that the life-threatening suppression of itraconazole by isotretinoin in the previously reported patients was most likely simply not noticed by the treating physicians (4–6). So their recommendation to use isotretinoin in patients with CGD must be carefully revisited (4–6). We here highlight the need to at least closely monitor levels of itraconazole when given together with systemic isotretinoin, if not the necessity to refrain from isotretinoin for treatment of acne vulgaris if cotreatment with itraconazole is mandatory as in CGD. The increased metabolism of itraconazole by systemic isotretinoin leading to induction of cytochrome P450 is highlighted in the pharmaceutical information on isotretinoin and is probably well known to the dermatologist. However to our knowledge, our report for the first time explicitly shows that comedication of itraconazole with systemic isotretinoin may cause dangerously low levels of itraconazole in CGD. The potentially life-threatening suppression of itraconazole by isotretinoin must be considered when using isotretinoin for a common and non-life-threatening condition like acne vulgaris in patients with CGD.
Blood ammonia concentration after supramaximal treadmill running in males and females.

The purpose of this study was to investigate the difference in human blood ammonia content between the sexes and the relationship between work.lean body mass (LBM)-1 and the peak blood ammonia content following supramaximal exercise. Eight males and six females ran on a motor-driven treadmill reaching exhaustion induced in less than 70 s. Total work, heart rate (HR), blood lactate and ammonia concentrations were measured at rest, immediately after warming-up, and at 2.5, 5, 7.5, 10, 12.5, 15 min after supramaximal exercise. Total work and work.LBM-1 were significantly greater in males than in females (p < 0.01). There was a significant relationship between the peak blood ammonia content and work.LBM-1 in all of the subjects (r, 0.627: p < 0.05). Though no significant difference was found in ammonia at rest between males and females, the peak blood ammonia content after supramaximal exercise in males was significantly greater than in females (p < 0.05). These results suggest that the peak blood ammonia content relates positively to anaerobic work capacity following supramaximal exercise, and that a difference in blood ammonia content exists between the sexes.
De-anonymization of traffic traces

In this paper we try to de-anonymize, an anonymized trace to see how real this threat of de-anonymization is. To do this first it is explained what the current anonymization and deanonymization methods are. After that we actually deanonymize a trace as much as possible. This is something we have not seen in other research as most researchers aim to prove de-anonymization is possible. The goal of this research is to see what happens after a trace is de-anonymized. We have come to the conclusion that although the results from our de-anonymization process were somewhat disappointing, a very large part can be de-anonymized using traffic injection.
Omni channel shopping behaviour during the customer journey

Disclaimer This document contains a student thesis (bachelor's or master's), as authored by a student at Eindhoven University of Technology. Student theses are made available in the TU/e repository upon obtaining the required degree. The grade received is not published on the document as presented in the repository. The required complexity or quality of research of student theses may vary by program, and the required minimum study period may vary in duration.
Reconfigurable monopole antennas

Two types of frequency agile Co-planar Waveguide (CPW) filters are introduced. Both filters utilize specially designed slots along with varactors and diodes. Filter designs are explained and verified. When these filters are integrated with any wideband CPW antennas, these antennas become frequency reconfigurable as well. A Wideband mode can be obtained in the antennas by blocking the entrance to the filter slots and several narrow band modes are achieved by switching of different diodes or variation of varactor's capacitance attached to the filter. Reflection coefficient and radiation pattern measurements are performed for the manufactured antennas. Good agreement between simulated and measured results is obtained.
The Impact Of Just In Time On Firm Performance

This paper explores whether different supply chain management choices such as just-in-time and non-just-in-time, which has different inventory cost has an effect on firm performance and whether or not the firm adopts the innovation approach such as JIT could increase productivity, reduce inventory and improve quality. The results indicated statistically significant differences in inventory, days to sell inventory, inventory turnover, ROA, sales, cost of goods sold, gross profit margin between JIT and non-JIT. It concluded that the adoption and implementation of innovation approach of supply chain management such as JIT did have a significant difference and improvement on firm performance.
Influencing Factors of Sports Events Audiences' Satisfaction Degree

Currently,sport marketing is a hot issue in the sports industry.In this paper,we selected the audiences from Beijing,Shanghai,Guangzhou,Shenyang and Dalian as the empirical study subjects.In the literature review,the research was based on the use of factor analysis,structural equation approach.The findings indicate:sports performance and service quality of audience satisfaction has a direct positive impact;sports performance and service quality through the event viewer satisfaction of the affected areas have indirect positive effects.
Tort Liability, Insurance Rates, and the Insurance Cycle

exhibit soft-market periods, where premium rates are stable or falling and coverage is readily available, and subsequent hard-market periods, where premium rates and insurers’ reported profits significantly increase and less coverage is available. Conventional wisdom among practitioners and other observers is that soft and hard markets occur in a regular “underwriting cycle. ” Like price fluctuations in equity markets, fluctuations in insurance premium rates and coverage availability are difficult to explain fully by standard economic models that assume rational agents and few market frictions. The mid-1980s “liability insurance crisis” remains the most infamous hard market in the United States. The dramatic increases in commercial liability insurance premiums and reductions in coverage availability for some sectors received enormous attention, motivating extensive research on those specific problems and on fluctuations in insurance prices and coverage availability more generally. Large losses from natural catastrophes in the United States during the late 1980s and early 1990s spurred further interest in and research on the dynamics of pricing in reinsurance and primary insurance markets following large, industry-wide losses. The hard market for commercial property and casualty insurance that began in late 2000 and accelerated following the destruction of the World Trade Center in September 2001 focused renewed attention on markets for commercial
An approach to a low dimensional covariance matrix for minimum variance beamforming

The beamforming techniques greatly reduce the contribution of undesired off-axis signals by applying proper delays and weights on the received signals to an array transducer. Minimum variance adaptive beamforming method achieved a great success in improving ultrasound imaging resolution due to the use of environmental information and updating the apodization for each point. In spite of its high performance, its computational complexity is as high as O(M3) where M is the number of array elements. This paper describes a new approach to reduce computational complexity of the MV by applying the beamforming method in a cascade structure. At the first stage, the interference signals received from the points far from the main axis are strongly suppressed. At the second stage, the interference signals from points close to the focal point that are received by the array are eliminated.
Enamel Hypomineralization and Structural Defects in Amelotin-deficient Mice

Amelotin (AMTN) is a relatively recently discovered enamel protein that is predominantly expressed by ameloblasts during the maturation stage of amelogenesis and is present at lower levels in the junctional epithelium of erupted teeth. Previous studies have suggested a function of this protein in enamel mineralization and cell attachment. Genetic mouse models have been instrumental in defining the role of many enamel-related proteins, but a genetic mouse model lacking the Amtn gene has not been reported. Here, we describe the generation of amelotin-deficient mice and the analysis of their enamel phenotype in comparison with that of wild-type animals. Ablation of AMTN expression resulted in mechanically inferior enamel of mandibular incisors that showed chipping and fractures at the incisal edge. Enamel mineralization was delayed, resulting in hypomineralized inner enamel and structural defects in the outer enamel. Erupted enamel close to the gingival margin showed increased surface roughness. The expression levels of the enamel matrix proteins AMEL, AMBN, ENAM, and ODAM and the enamel proteases MMP-20 and KLK-4 were not significantly altered, although the expression of KLK-4 was delayed. The morphology of ameloblasts showing prominent Tomes’ processes during the secretory stage was not altered, and there was no indication of disruption of cell structures or activities, but a residual layer, presumably consisting of organic material, remained at the enamel surface close to the gingival margin. The integrity of the dentogingival attachment at the junctional epithelium appeared unaffected by AMTN deficiency. These observations indicate that AMTN plays a subtle yet critical role in enamel biomineralization, particularly during the establishment of the outer and surface enamel layers. This role appears to be largely independent of other enamel proteins.
Sexual risk behaviour relates to the virological and immunological improvements during highly active antiretroviral therapy in HIV-1 infection

ObjectivesTo evaluate the effect of highly active antiretroviral therapy (HAART) on the sexual behaviour of homosexual men, we conducted (i) an ecological study of time trends in sexual behaviour and sexually transmitted diseases; (ii) a HAART-effect study focused on the practice of unprotected anogenital sex. DesignSubjects were participants in the ongoing Amsterdam Cohort Studies (ACS) among homosexual men, initiated in 1984. Data for (i) represented all ACS visits by HIV-1-positive and -negative participants who entered ACS at or below 30 years of age and were followed until 35 years (n = 1062). Data for (ii) represented all ACS visits of HIV-1-positive men from 1992 to 2000 (n = 365), of whom 84 were HAART recipients with at least 2 months of behavioural follow-up. Results(i) After HAART became generally available in July 1996, unprotected sex was practised more frequently and the incidence of gonorrhoea was higher compared to March 1992–June 1996 among HIV-1-negative and -positive men, respectively. (ii) Among HIV-1-positive men, a higher level of unprotected sex with casual partners was observed after HIV-1 RNA became undetectable and CD4 cell counts increased with the use of HAART. Notably, in individuals who did not receive HAART, high HIV-1-RNA levels (above 105 copies/ml) were likewise related to unprotected sex with casual partners. ConclusionData support the need for the reinforcement of safe sex prevention messages among HIV-1-negative men, and our data also provide a lead for redirecting and tailoring current prevention strategies to the needs of HIV-1-positive men.