Miracle-dz/UniFAR-FTUs huggingface dataset:
The Efficacy and Safety of Glucocorticoids Plus Conventional Therapy for Hepatitis B-Related Liver Failure in China: A Meta-Analysis

Context: The aim of this meta-analysis was to evaluate the eﬃcacy and safety of glucocorticoid plus conventional therapy in hepatitis B-related liver failure. Evidence Acquisition: A systematic search was performed in PubMed, Embase, the Cochrane library, China National Knowledge Infrastructure, Wanfang database, and Google Scholar. The primary outcome was improvement in the mortality rate and the secondary outcome was the incidence of complications. Pooled data were based on the ﬁxed-eﬀect model. Results: Tenstudieswith891patientswereincludedinthemeta-analysis. Glucocorticoidplusconventionaltherapy(OR=3.98, 95% CI:2.80-5.66;P=0.000)wassuperiortoconventionaltreatmentaloneandreducedthemortalityrate(OR=0.38,95% CI[0.20,0.74], P = 0.004). Moreover, the incidence of complications, such as hepatic encephalopathy (OR = 0.34, 95% CI [0.19, 0.60], P = 0.000), hepatorenal syndrome (OR = 0.22, 95% CI [0.10, 0.47], P = 0.000), electrolyte imbalance (OR = 0.27, 95% CI [0.12, 0.62], P = 0.002), and ascites (OR = 0.50, 95% CI [0.28, 0.90], P = 0.021), were reduced. No statistically signiﬁcant diﬀerences were found between the two groups in terms of lung infection (OR = 0.76, 95% CI [0.27, 2.10], P = 0.595), gastrointestinal bleeding (OR = 0.48, 95% CI [0.23, 1.00], P = 0.050), and bacterial peritonitis (OR = 0.70, 95% CI [0.31, 1.58], P = 0.396). Conclusions: Ourmeta-analysissuggeststhatglucocorticoidplusconventionaltreatmentreducedtheincidenceof complications. Thus combination therapy could be an eﬀective and safe approach in treating patients with hepatitis B-related liver failure.
Study of diagnostic procedures and histopathology in primary malignancies in a tertiary care centre

Background: Primary lung cancer is a leading cause of cancer related death all over the world. In Indian scenario lung cancer is increasingly diagnosed because of beedi and cigarette smoking and majority of times diagnosed in an inoperable stage resulting in poor prognosis. Materials and Methods: In this study we have analysed the diagnostic modalities and histo-pathological analysis of the specimen obtained and correlated with the smoking status and age of the patients. A total of 113 patients having clinical and radiological profile suggestive of primary lung cancer are taken in to the study. Among them only 100 patients were diagnosed as malignancy by histopathological examination. For the confirmation of the diagnosis transthoracic needle aspiration biopsy with the help of ultrasonography and CT scan, bronchoscopic biopsy and bronchial washings, lymph node biopsy and pleural fluid analysis were undertaken. Results: Positive specimens were obtained by TTNA in 54%, Bronchoscopic biopsy and washings in 30%, pleural fluid analysis in 12% and lymph node biopsy in 4% of patients. 82% are males and 18% are females. 82% are smokers and 18% are nonsmokers. 68 patients presented with mass lesions and 73% of them presented with a mass of >5cm in diameter. 27% presented as mass lesions less than 5cm in diameter. Smokers have more mass lesions and more N3 disease and the values are statistically significant. (p
Ascorbic acid and testosterone efficacy in spermatoxic and histomorphological changes in Corpora cavernosa in priapism induced sprague-dawley rats

Aim: The histomorphological changes in the corpora cavernosa following priapism remains an interesting observation due to its pathological and reproductive implications. We investigated the attenuating effect of testosterone and vitamin C on the corpora cavernosa induced fibrosis in priapism of rats. Methods: Twenty-five Sprague – Dawley male rats were randomly allocated into 5 groups of rats each Group 1 served as the control. Group 2 had only priapism. Group 3 was induced with priapism and then treated with vitamin C. Group 4 was induced with priapism and then treated with testosterone. Group 5 was induced with priapism but were treated with both vitamin C and testosterone. Priapism was induced for one week followed by 6 hours’ post priapism administration of testosterone and vitamin C. Results: Results showed fibrotic corpora cavernosa in all groups except the control group. Sperm parameters indicated oligospermia and reduced sperm motility especially in group 2 and 3 when compared with the control group. Conclusion: The results indicated that testosterone and vitamin C ameliorated priapism-induced ischemia – reperfusion injury at different time intervals in rats. Key words: Priapism, Corpora cavernosa, Infertility, Testosterone, Vitamin C.
Psychoneuroimmunology of oral diseases - a review

Background: Various oral stimuli that are perceived by the brain as stressful can trigger patterns of neurological activity which then directly influence immune and endocrine response. Objective: To analyze the psycho-neuro-endocrine-immunological interactions involved in oral diseases and conditions. Data sources: Web of Science, PubMed, Google Scholar were databases researched for peer review articles in indexed journals. Study selection: A literature search limited to peer-reviewed articles in indexed journals published before January 2019 was performed using specific keywords. 107 articles were selected. Data extraction: The aspects related to psycho-neuro-immune interactions relevant for dental practitioners were synthesized and presented in the form of narrative review. Oral diseases and conditions in which psychological factors act through neurological, endocrine and immunological mechanisms are discussed. The following clinical entities were included: periodontitis, oral lichen planus, recurrent aphthous stomatitis, temporomandibular disorders, herpes labialis, burning mouth syndrome, and atypical odontalgia. Additionally, the role of psychoneuro-immunological factors on bacterial adherence and oral microbiome is briefly discussed. Data synthesis: Various oral diseases and conditions of multifactorial etiology can be influenced by psycho-neuro-immunological interactions. In daily practice, clinicians should be aware of the interplay between mental and general health and consider addressing psychological disturbances as a supplement for conventional treatment modalities. Recognizing these interactions should help to better understand the relationship between mental and physical health.
Queueing performance comparison of traffic models for Internet traffic

There are a fast-growing number of studies in the literature that deal with capturing the statistical properties of today's data traffic. However, little progress has been made in regard to the question of how traffic characteristics like long range dependence/self-similarity or heavy-tailed distributions of interarrival times impact the engineering of data networks. We compare the performance prediction of a wide range of traffic models for a number of performance measures that are common in network engineering. We investigate how accurately traffic models like Poisson, 2-state MMPP, AR(1), Weibull, Pareto, and FBM predict the queueing performance like loss probabilities and queue lengths (delays) when compared to results from measured Internet traffic. The numerical results lead to the conclusion that traffic models that are based on heavy-tailed distributions like the Pareto distribution are needed when dealing with small buffer sizes. For larger buffer sizes, the effect of long range dependence that is present in the data traffic influences the queueing behavior considerably and therefore traffic models that exhibit long range dependence like FBM are needed. It is interesting to see how the long range dependent traffic models fail to predict the queueing performance for small buffer sizes. This indicates that the choice of the traffic model depends not only on the type of traffic but also on the considered application/device in terms of buffering.
Cleft lip and palate assessment form: Medical history, oral-peripheral characteristics, speech problems

Objective: The objective of the study is to identify the medical histories, oral-peripheral characteristics and speech problems of children with cleft lip and palate (CLP) or craniofacial anomalies, and eventually create an assessment form that highlights the factors that should be taken into consideration in the examination of those children. Materials and Methods: An assessment form was developed and used to assess with a descriptive method the medical history, oral peripheral, speech, and resonance characteristics of children with CLP. The study included 56 (21 females and 35 males) children with CLP. The results are presented as frequency or percentage. Results: About 20% of the CLP patients were offspring of consanguineous marriage and about 30% had positive family history of CLP. The major difficulty families experienced was feeding. Hearing impairment at various degrees was reported in 23% of the participants. The presence of cardiovascular, renal, neurological and endocrinological problems, and symptoms addressed in peripheral examination were identified as critical in discriminating syndromic cases. Assessment of the speech skills showed backing to be the most prevalent error among the participants. Conclusion: The form that was developed in scope of this study was observed to successfully define the medical history, oral-peripheral characteristics and speech problems of individuals with CLP. The form, however, needs further testing in larger populations and comparison to non-CLP populations.
Locating Failure-Inducing Code Changes in an Industrial Environment

A regression is a common type of failure that occurs while changing source code of a working program: “Yesterday, your program worked. Today, it does not. Why? ” Manual debugging of regressions is costly in terms of labour and time, it annoys developers and costs organisations lot of money. This thesis presents a platform that integrates seamlessly automated determination of failureinducing code changes with common development processes. Automated determination may increase efficiency, improve productivity, while saving time and money. Because established processes need not to be adapted, start-up costs and risks are low. The platform supplies two tools in form of plug-ins. A Eclipse plug-in integrates automated determination of failure-inducing changes with a prominent IDE. As soon as a unit test fails, it can be debugged automatically. A Maven plug-in enriches continuous building and testing with automated debugging. Instead of a simple failure report, we obtain valuable information about failure-inducing changes—without lifting a finger: “The failure cause is the change in line 37 of file StringUtils.java. ” The plug-ins are instances of a framework that contains all basic functionality in order to build tools that enable automatic determination of failure-inducing changes. Using that framework, implementing new tools that debug other types of failure is quite easy and simple—again saving time and money.
Estimação da Direção de Disparo de Arma de Fogo: Uma Implementação em Tempo Real

Resumo—O presente artigo apresenta a proposta de um sistema em tempo real para a detecção e a estimação da direção de chegada de sinais de áudio provenientes de um disparo de arma de fogo. Utiliza-se umhardware específico para processamento em tempo real e um arranjo espacial de 7 microfones. Após detectado, o sinal é processado por um algoritmo de estimaçã o de direção de chegada, DoA ( Direction of Arrival), que utiliza a correlação cruzada generalizada para medir as diferenças de tempo de chegada entre os pares de microfones. Utilizando técnicas de implementação em tempo real, não ocorre perda de informação do ambiente pois os processos de detecção do sina l e de estimação de DoA ocorrem em paralelo.
Multifunctional role of pancreatic stellate cells in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer related deaths with a dismal 5-year survival rate of only 8%. PDAC is characterised by extensive desmoplasia constituting about 50–80% of the tumour volume. Activated pancreatic stellate cells (PSC) are the major cellular source for stromal collagen; these cells drive pancreatic fibrosis and progression of PDAC. PSC are known to be activated by paracrine signals from several sources including injured epithelium, cancer cells, extracellular matrix, immune cells and nerve cells. Stromal-tumour interactions are now recognised as key processes in the development and progression of PDAC. Improved understanding of the mechanisms underlying stromal-tumour interactions may be the key for the discovery of new therapeutic targets in PDAC. This review summarises current knowledge regarding the role of PSCs in cancer biology and discusses the potential for development of novel therapeutic approaches targeting factors such as dysregulated signalling pathways, the stromal reaction itself and epigenetic changes in stromal and/or cancer cells.
Primäre entzündliche Ursachen zerebraler Ischämie im Kindesalter

Zusammenfassung Ischämische Hirninfarkte sind im Kindesalter selten, können aber bei den betroffenen Individuen zu irreversiblen Schäden und einer schwerwiegenden Beeinträchtigung der Lebensqualität führen. Ein signifikanter Anteil der Infarkte im Kindesalter geht auf primäre ZNS Vaskulitiden (PACNS) zurück. Zur sicheren Diagnose müssen Differenzialdiagnosen, inklusive Systemerkrankungen die mit Vaskulitis einhergehen können ausgeschlossen werden. In Analogie zur Klassifikation der systemischen Vaskulitis, wird die PACNS nach dem Kaliber der betroffenen Gefäße eingeteilt. Die Diagnose und Einteilung erfolgt anhand der klinischen Präsentation, laborchemischer und bildgebender Untersuchungen, sowie Hirnbiospien im Falle von Kleingefäß ZNS Vaskulitiden. In Ermangelung prospektiver und kontrollierter klinischer Studien orientiert sich das therapeutische Vorgehen derzeit an kleinen Fallserien und Expertenempfehlungen. Die zur Verfügung stehende Medikamententherapie umfasst systemische Antikoagulation, hochdosierte Kortikosteroide und, wenn nötig, Cyclophosphamid zur Remissionsinduktion, sowie Basismedikamente zur Remissionserhaltung. Die Pathophysiologie der PACNS wird aktuell nur sehr inkomplett verstanden. Die Untersuchung und Entdeckung genetischer Ursachen wird jedoch zu einer Neuklassifikation und zielgerichteten und individualisierten Therapieoptionen beitragen. Um dies voranzutreiben sind nicht zuletzt aufgrund der Seltenheit der PACNS im Kindesalter internationale Kooperationen notwendig.
Impact of Self-Citations on Impact Factor: A Study Across Disciplines, Countries and Continents

Purpose. The present study is an attempt to find out the impact of self-citations on Impact Factor (IF) across dis ciplines. The study examines the number of research articles published across 27 major subject fields covered by SCImago, encompassing as many as 310 sub-disciplines. The study evaluates aspects like percentage of self-citations across each discipline, leading self-citing countries and continents, and the impact of self-citation on their IF. Scope. The study is global in nature, as it evaluates the trend of self-citation and its impact on IF of all the major subject disciplines of the world, along with countries and continents. IF has been calculated for the year 2012 by analyzing the articles published during the years 2010 and 2011. Methodology/Approach. The study is empirical in nature; as such, statistical and mathematical tools and techniques have been employed to work out the distribution across disciplines. The evaluation has been purely undertaken on the secondary data, retrieved from SCImago Journal and Country Ranking. Findings. Self-citations play a very significant part in inflating IF. All the subject fields under study are influenced by the practice of self-citation, ranging from 33.14% to 52.38%. Compared to the social sciences and the humanities, subject fields falling under the purview of pure and applied sciences have a higher number of self-citations, but a far lesser percentage than the social sciences and humanities. Upon excluding self-citations, a substantial amount of change was observed in the IF of subject fields under study, as 18 (66.66%) out of 27 subjects fields faced shuffle in their rankings. Variation in rankings based on IF with and without self-citation was observed at subject level, country level, and continental level.
Optische Kohärenztomografie im akuten ST-Hebungsinfarkt

Da die Koronarangiografie (▶ Abb. 1) keinen eindeutigen Befund lieferte, wurde eine weitere intravasale Bildgebung mittels optischer Kohärenztomografie (OCT) veranlasst (▶ Video 1). Im Stromgebiet des Ramus interventricularis (RIVA) zeigte sich ein pathologischer Befund. FRAGEN ▪ Welcher Befund ist zu sehen? ▪ Erlaubt dieser Befund eine Diagnose? Wenn ja, welche? ▪ Sind Differenzialdiagnosen möglich? Wenn ja, welche? ▶ Abb.1 Koronarangiografie des Ramus interventricularis (RIVA) und Ramus circumflexus (RCX). OP-VIDEO
A XSS Vulnerability Detection Approach Based on Simulating Browser Behavior

This paper presents a dynamic detection method based on simulating browser behavior, and designs a web crawler based on a headless browser, which can interpret the JavaScript code and retrieve Ajax content to find the hidden injection points in pages, with full consideration of the web pages containing complex scripts under Web 2.0 environment. In implementation, this paper uses dynamic analysis in XSS vulnerability detection by examining the runtime behavior of web application, and decide whether the XSS vulnerability exists with black-box test. The experiment results prove that this method works.
Lobaplatin-Induced Apoptosis Requires p53-Mediated p38MAPK Activation Through ROS Generation in Non-Small-Cell Lung Cancer

Platinum-based chemotherapy is recommended as the first-line treatment regimen for patients with advanced non-small-cell lung cancer (NSCLC). Lobaplatin (LBP), a third-generation platinum anti-neoplastic agent, has shown an improved efficacy. This study is aimed to investigate the mechanisms of LBP-induced apoptosis in the A549 p53 wild-type cell line. The Cell Counting Kit-8 assay (CCK-8), flow cytometry (FCM), Western blot, xenograft tumor models, terminal deoxynucleotide transferase dUTP nick end labeling (TUNEL), and RNA interference were used in this study. Our results showed that the proliferation of A549 cells could be inhibited by LBP. At lower concentrations, LBP triggered cell cycle arrest at the G1 phase in A549 cells. LBP could also induce apoptosis of A549 cells. LBP also increased the expression of PARP and Bax and the cleavage of caspase-3, caspase-8, and caspase-9 and reduced Bcl-2 expression. In vivo experiment confirmed that LBP could inhibit tumor growth in the A549 xenograft models and induce apoptosis. Apoptosis of A549 cells was decreased after transfected with p53 shRNA or treated with reactive oxygen species inhibitor NAC and p38MAPK inhibitor SB203580, suggesting that the p53/ROS/p38MAPK pathway appeared to mediate the LBP-induced apoptosis of A549 cells. Our data demonstrate that LBP could be a promising candidate for the treatment of NSCLC with wild-type p53.
Results of Abdominopelvic CT Scan in patient with abdominal pain

Background: CT scan is an imaging device that is widely available and is very sensitive to different causes of abdominal pain. The aim of this study was to evaluate the CT scan results role of patients with abdominal pain in diagnosis and future decisions on patient and comparison with patient’s history and physical examination. Methods: In this descriptive analytical study, 215 patients admitted to the emergency room at Imam Reza Teaching Hospital with non-traumatic abdominal pain were studied over the years regarding the comparison of CT findings with the history, physical examination, plain radiography and ultrasound. Demographic characteristics, patient history, symptoms at the first visit, clinical findings, laboratory tests, imaging findings, diagnosis and treatment of all patients were collected. Results: CT scan to confirm the diagnosis or screening patients with abdominal pain has been helpful. The results of 215 CT scan 28.40% was normal, most frequently diagnosis in CT scans was related to pancreatitis 24% and least diagnostic of CT scans related to ileus. Of 215 patients, plain abdominal radiography was requested in 78 patients (36.3%) that the air-fluid level was reported in 18 cases (23.7%). Of 215 patients, abdominal ultrasonography was performed in 117 patients (54.4%) that the most recognizable diagnosis was cholelitiasis in 22 cases (18.8%) an abdominal ultrasound result was normal in 98 cases (83.7%). Finally of the 215 patients, 116 patients (77.2%) admitted and 49 patients (22.7%) were discharged. Of 166 patients, 51 patients (30.72%) were transferred directly from the emergency department to the operating room. Conclusion: CT scan play a decisive role in the decision to hospitalize patients and request in right place expedite the handling patients. Our study suggests the balance between the amount of requested CT in patients with non-traumatic abdominal pain and hospitalization rate.
Performance of PIC, SIC and decorrelating detectors for MUD technique in WCDMA system

The wideband code division multiple access (WCDMA) has been selected as the main air interface standard used to meet the high capacity and high bandwidth requirements of the third generation mobile system. The main problem of this technology is multiple access interference (MAI). Various multiuser detection (MUD) methods have been proposed to mitigate this problem. By using multiuser detection (MUD) based interference suppression or cancellation where code and timing (amplitude and phase) information about multiple users are used jointly to detect each individual user more intelligently, system capacity can be significantly improved and possibly less channel coding is needed (Prasad, R et al. 2000). In the search for suitable MUD solutions most emphasis has been placed on the performance and complexity of narrow band CDMA. The question of performance and complexity of MUD techniques under WCDMA system has not been fully explored. In this paper, the performance of MUD under WCDMA system has been evaluated. In the receiver, multistage successive interference cancellation (SIC), multistage parallel interference cancellation (PIC) and decorrelating detector are used to eliminate MAI.
Prevalence of trichomonas vaginalis in women referred to vali- asr polyclinic and the health center number 3 in Sirjan city

To determine the prevalence of trichomoniasis in Sirjan city, the vaginal discharges of 500 women were examined by direct smear and culture methods from June to December 1992. ( Two hundred thirty women referred to vali-asr polyclinic and 270 to the health center number 3). The mean age of the women was 30 years and a higher percentage of referrals were between 30-34 years. In respect to the occupation and education of the subjects, most of them were housewives and school educated (2.8℅ and 3.5℅ were infected, respectively). There was no significant difference between age, occupation, income, husband's occupation, contraceptives methods, dyspareunia, vaginalis, cervicitis, frequency, antibiotics usage, and vaginal pH with trichomoniasis. On the contrary, husband's education, and quantity of vaginal discharge had significant relations with the disease. Overall prevalence of trichomonas vaginalis was 2.8℅ by culture and 2.2 by direct smear method. The sensitivity of direct smear compared with the culture method was 78℅ . The prevalence of trichomoniasis among the women was 3.5℅ and 2.2℅ in Vali- asr polyclinic and health center, respectively. However, there was no significant difference between the two groups.