Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Depression on Health-Related Quality of Life among Skin Cancer Survivors

Introduction : Skin cancers are one of the most common cancers in the United States (US). Studies have reported depression to be a common comorbid condition among individuals with skin cancer. This study aimed to evaluate the relationship of depression with health-related quality of life (HRQOL) among individuals with a skin cancer diagnosis. Methods : A cross-sectional study design using the 2017 Behavioral Risk Factor Surveillance System (BRFSS) data, a nationally representative sample of non-institutionalized US adults, was utilized for the study. Multivariable logistic regression was used to assess the relationship between depression and the HRQOL domains (general health status, physical health, mental health, and activity limitations due to poor physical or mental health) among survivors of skin cancer. Results : Comorbid depression was identified in 20% of skin cancer survivors. After adjusting for covariates, skin cancer survivors with depression had higher odds of having poor general health status (Odds Ratio [OR] = 1.67, 95% Confidence Interval [CI] 1.41-1.98) as compared to skin cancer survivors without depression. Skin cancer survivors with depression also had greater odds of having poor physical HRQOL (OR = 1.82, 95% CI 1.53-2.15), poor mental HRQOL (OR = 6.38, 95% CI 5.26-7.74), and activity limitations (OR = 2.42, 95% CI 2.03-2.89) as compared to those without depression. Conclusion : This study highlights the significant negative impact of comorbid depression on HRQOL in a nationally representative sample of skin cancer survivors, and serves as evidence for the need for more active surveillance and management of depression in this population.
RETINOBLASTOMA IN ADULTS: A CASE REPORT AND LITERATURE REVIEW (CASE REPORT)

Purpose: To report a case of adult retinoblastoma with a wrong diagnosis of melanoma. Case report: Herein, we present an adult retinoblastoma case who was misdiagnosed as melanoma in fine‐needle aspiration biopsy with intravitreal hemorrhage and later neovascular glaucoma after biopsy. The diagnosis of retinoblastoma was confirmed after enucleation. Conclusion: Retinoblastoma should be considered in the differential diagnosis of an intraocular mass in adults, especially when media haziness precludes adequate ophthalmoscopic visualization.
Hubungan Antara Kepatuhan Mengikuti Program Pengelolaan Penyakit Kronis (PROLANIS) BPJS dengan Stabilitas Gula Darah pada Penderita Diabetes Melitus di Puskesmas Babat Kabupaten Lamongan

The stability of blood sugar plays an important role in the management of diabetes. Diabetes blood sugar level is determined by adherence to the four pillars of Management DM. This is facilitated by the government through PROLANIS managed by BPJS. The purpose of the study was to determine the relationship between adherence to follow PROLANIS with stability of blood sugar in people with diabetes. The research design was correlational cross sectional analytic quantitative non-experimental approach. The sampling of this research used total sampling with 82 participants that was member of PROLANIS at Public Health Center of Babat Lamongan. Datas were collected using a questionnaire dietary compliance, Baecke, MMAS-8 and the medical records of patients. Statistical test results using alternative fisher exact test showed p = 0.000 <α (0.05) which means there was a significant relationship between adherence follow PROLANIS with the stability of blood sugar. This shows that the higher level of compliance has better stability of blood sugar. Based on the four pillars of PROLANIS majority of people with diabetes do not adhere to education (61%), physical activity (56%), and treatment (52.3%), while the majority of people with diabetes adhere to a diet (90.2%). The conclusion is that there was a relationship between compliance with follow PROLANIS blood sugar stability so that it can be used as a reference for people with diabetes to improve compliance with the 4 pillars PROLANIS management of DM in order to have a stable blood sugar.
Pemanfaatan Teknologi Informasi dan Komunikasi dalam Industri Fashion Indonesia

Dalam perkembangan ekonomi saat ini, pengetahuan teknologi informasi dan komunikasi (TIK) memainkan peran yang sangat penting dalam pertumbuhan dan daya saing organisasi. Pada sektor ekonomi kreatif, subsektor fashion merupakan pemberi kontribusi nomor dua terbesar. Namun sayangnya pemanfaatan teknologi informasi dan komunikasi dalam industri fashion di Indonesia nyatanya belum menggunakan TIK secara maksimal. Saat ini fashion bukan lagi hanya tentang pakaian, melainkan gaya hidup yang tidak dapat terlepas dari manusia modern. Dalam industri fashion, inovasi merupakan faktor penting dalam keputusan pembelian konsumen. Artikel konseptual ini memberikan gambaran mengenai penerapan ITK dalam konsep e-commerce, big data analytics dan user experience yang terbukti mampu memberikan pengaruh dalam pengembangan industri fashion di Indonesia.
Ergebnisse aus der Evaluation der Gesund und aktiv leben-Kurse – Inanspruchnahme, Outcomes, Akzeptanz

Internationale Untersuchungen zum CDSMP (vergleichbar mit den Gesund und aktiv leben-Kursen, siehe Kapitel 10) haben bereits gezeigt, dass die Teilnahme am Kursprogramm bei chronisch kranken Menschen unter anderem zu einer verbesserten Arzt-Patienten-Kommunikation, zu mehr Bewegung und einer Verbesserung des selbsteingeschätzten Gesundheitszustandes führen kann (Brady et al. 2013). Außerdem zeigten sich gesteigerte Selbstmanagementfähigkeiten (Stone/Packer 2010; Cheng et al. 2016) und in deutschsprachigen Kursen in Österreich und der Schweiz Verbesserungen der Selbstwirksamkeitserwartung der Kursbesucherinnen und -besucher (Haslbeck et al. 2015). Ob ähnliche Ergebnisse auch bei den Teilnehmenden der INSEA Gesund und aktiv leben-Kurse in Deutschland beobachtet werden können, wird mit einer umfangreichen kursbegleitenden Evaluation untersucht. Die Evaluation ist zudem Voraussetzung für den Erhalt der Stanford-Lizenz: alle auf Basis der Lizenz durchgeführten Kurse müssen zu unterschiedlichen Zeitpunkten hinsichtlich ihrer Wirksamkeit und Nachhaltigkeit überprüft werden. Die Evaluation ist Aufgabe der Nationalen Koordinierungsstelle von INSEA. In einer Kooperationsvereinbarung ist festgelegt, dass die Praxispartner, also die Einrichtungen, die die Kurse anbieten, zur Mitwirkung verpflichtet sind. Im Mittelpunkt der Evaluation stehen drei Aspekte:
Intelligent identification of Acute kidney injury empowered with Heterogeneous Mamdani Fuzzy Inference System

In this article, a new Heterogeneous-Layered Mamdani Fuzzy Inference System (HL-MFIS) is proposed to detect the Acute Kidney Injury. The proposed computerized system Detect of AKI Using Heterogeneous Mamdani Fuzzy Inference System (DAKI-HL-MFIS) Expert System, can detect the Acute Kidney Injury or No-AKI. The Expert System has two input variables at layer-I and seven input variables at layers-II. At layer-I input, variables are Creatinine and BUN that detects the output condition of a Kidney to be Normal, or Acute Kidney Injury. The further input variables at layer-II are Glomerular filtration rate, urine Albumin, sodium, potassium, chloride, calcium, and phosphorus that determine the output condition of Kidneys like Acute kidney Injury and other reasons that arise due to enzyme vaccination or due to past Kidney Injury. The overall accuracy of the DAKI-HL-MFIS Expert system is 90.5%.
The International Tourism Demand for Indonesia: Expenditure Approach

This study aims to analyze the determinant of Indonesian tourism demand with the tourist expenditure approach. The data used in this study are from 31 countries with data series 2003 to 2017. The method used in this study is a dynamic panel with the first difference-GMM estimation method. Many studies use standardized tourism price data. In policy, it is also necessary to consider the price of tourism competitors. The use of tourism prices and competitor prices together if standardized with exchange rates can lead to high multicollinearity. So that tourism prices, competitor prices, and exchange rates are used as each variable. This research found that the income of tourists has a positive effect on demand, but it is not large. Relative prices and exchange rates are the biggest determinants of tourism demand. Appreciation of the exchange rate and the increase in prices in Indonesia can reduce the demand for tourism relatively. While competitor prices show a complementary relationship, rising prices in competing countries will also reduce tourism demand in Indonesia. This research suggests to the government to keep competitive prices to increase tourism demand because the tourist budget is prepared at the beginning by tourists but the value of shopping in the destination country depends on the value of the rupiah and the prices of tourism products in Indonesia.
Accurate power loss models of complex converters

Power loss estimation is essential for the design and optimization of power converters. Traditionally, the power loss estimation is done using datasheet-level information about the switching devices. However, this information is limited to isolated operating points, compromising the accuracy of the estimation. In addition, the representation of PCB effects and gate driver, which cannot be considered by using datasheet parameters, increase the complexity of the tasks by adding more unknown magnitudes and more complex equations without guaranteeing their correct estimation. In this work, a novel power loss estimation method, which can be applied to any topology, is presented. This proposed method utilizes Design of Experiments (DoE) and Response Surface Methodology (RSM) to model the different types of losses in all the elements in a power converter such as power switches, diodes, and inductors. With RSM, simple equations explain the different types of losses as a function of variables that directly affect them allowing the losses estimation under any operating condition accurately. These models are extensively validated to show the advantage of using the proposed method and significant improvement with respect to datasheet calculations is obtained. For complex topologies such as Power Factor Corrector (PFC), accurate power loss estimation is not only necessary but also a challenge. To show the capabilities of the proposed model, it is applied to Universal PFC, which is a complicated converter in terms of loss calculation and analysis. Using the proposed models, the inductor is designed optimally and the optimal switching frequency is selected to minimize the losses in the different input voltage levels. Experimental validation of the proposed method, prediction, and design impact is presented; the proposed method yields a power loss reduction up to 25%, having the greatest improvement at an input voltage of 110 V, and an output power higher than 500 W.
Recurrent pre-leukemic deletions in myeloid malignancies are the result of DNA double-strand breaks followed by microhomology-mediated end joining

The mechanisms underlying myeloid malignancies deletions are not well understood, nor is it clear why specific genomic hotspots are predisposed to particular deletions. In the current study we inspected the genomic regions around recurrent deletions in myeloid malignancies, and identified microhomology-mediated end-joining (MMEJ) signatures in recurrent deletions in CALR, ASXL1 and SRSF2 loci. Since MMEJ deletions are the result of DNA double-strand breaks (DSBs), we introduced CRISPR Cas9 DSBs into exon 12 of ASXL1, successfully generating recurrent ASXL1 deletion in human hematopoietic stem and progenitor cells (HSPCs). A systematic search of COSMIC dataset for MMEJ deletions in all cancers revealed that recurrent deletions enrich myeloid malignancies. Despite this myeloid predominance, we provide evidence that MMEJ deletions occur in multipotent HSCs. An analysis of DNA repair pathway gene expression in single human adult bone marrow HSPCs could not identify a subpopulation of multipotent HSPCs with increased MMEJ expression, however exposed differences between myeloid and lymphoid biased progenitors. Our data indicate an association between MMEJ-repaired DSBs and recurrent MMEJ deletions in human HSCs and in myeloid leukemia. A better understanding of the source of these DSBs and the regulation of the HSC MMEJ repair pathway might aid with preventing recurrent deletions in human pre-leukemia.
The Relationship between Direct-to-Consumer Prescription Drug Advertising and Prescription Rates

Direct-to-consumer advertising (DTCA) has been a contentious issue ever since its introduction in the 1990s. Many in the medical field have suggested that DTCA misleads consumers, and causes them to demand prescriptions for newer, more expensive medications when older drugs, proven to be safe, would be just as effective. Proponents, however, suggest that DTC (direct-to-consumer) advertisements increase patients' awareness of available therapies, their adherence to treatments, and their likelihood of discussing medical conditions with physicians. In this paper I write the first systematic review, to my knowledge, of the literature on DTC advertising. Then I examine how the quality of DTC advertisements affects prescription rates. To determine the quality of a prescription drug advertisement I created a tool in collaboration with the Food and Drug Administration (FDA) which quantifies the content of the risk and benefit information and the presentation of the aforementioned information. I found a significant correlation between certain quality characteristics of DTC advertisements and prescription rates. I introduce the concept of the effective advertising expenditure (EAE) to predict the advertising expenditures per prescription. The advertising cost per new, refill, and total prescriptions is estimated with remarkable accuracy using the EAE for five drugs sales between 1999 and 2004. Implications of the effective advertising expenditures for drug companies and FDA regulators are also discussed.
A GSO depth of interaction detector for PET

The authors have developed a GSO depth of interaction detector. Three GSO scintillators with different concentration of Ce were chosen and stacked along depth of interaction direction and optically coupled to a photomultiplier tube (PMT) or a position sensitive photomultiplier tube (PSPMT). In the beginning, pulse shape, light output and zero-cross time were measured so as to select a proper combination of GSO scintillators with different concentrations of Ce. Selecting three GSO scintillators with different concentration of Ce, a single stacked GSO/PMT depth of interaction detector was fabricated for estimating the possibility of this method. Using the zero-cross time analysis, three peaks correspond to decay times of the three GSO scintillator were obtained. Finally, a GSO/PSPMT depth of interaction block detector was fabricated and tested. The block detector consists of 7/spl times/7 matrix of GSO scintillators which have three layers of different concentrations of Ce optically coupled to a PSPMT. The pulse shape analysis was used for determination of depth of interaction direction while the Anger logic was used for transaxial and axial directions. Good separations were obtained in depth of interaction direction as well as transaxial and axial direction. These results indicate that the GSO block detector may become one solution for developing a positron emission tomograph (PET) with depth of interaction detection capability.
An Environmental Scan of Health and Social System Navigation Services in an Urban Canadian Community

Systems navigation services provided by a designated provider or team have the potential to address health and social disparities. We conducted an environmental scan of navigation activities in a large urban Canadian community to identify and describe: service providers who engage in systems navigation; the clients who require systems navigation support and the issues they face; activities involved; and barriers and facilitators in providing systems navigation support to clients. Using an online survey and convenience sampling, we recruited individuals who self-identified as community navigators or practiced systems navigation activities as part of their role. The majority of respondents (n = 145) were social workers, social services workers, or nurses. Clients of navigators struggled with mental health or addictions issues, disabilities, chronic diseases, and history of trauma or abuse. The most frequently reported activities of navigators were building professional relationships, managing paperwork, and communicating with relevant agencies or organizations. Barriers to navigation were time available in the work day, difficulty partnering due to bureaucratic structures, differing philosophies and ways of working, and a lack of central information repository in the community. Facilitators were a client-centered organization, the availability of multiple community resources in the region, and organizational support. Participants struggled with client waitlists, system issues such as lack of resources and interagency collaboration, and role clarity.
Lightweight Dynamic Group Rekeying for Low-Power Wireless Networks in IIoT

In this article, a novel pseudorandom key chaining (PRKC) algorithm is introduced and evaluated. This lightweight symmetric scheme enables a transmission-triggered time variation of group keys in low-power wireless networks during broadcasting or multicasting. The proposed algorithm uses pseudorandom (PR) sequences, generated at the physical (PHY) layer of radio transceivers during a communication session, to symmetrically refresh the encryption keys on both sides of a communication link. This solution is scalable and suitable for large networks of nodes with limited resources in an Industrial Internet-of-Things (IIoT) environment. The strength of generated keys was tested with the use of the National Institute of Standards and Technology Special Publication 800-22 (NIST SP 800-22) statistical suit. No binary patterns that may indicate a vulnerability were detected. The randomness of generated key sequences was further analyzed with the use of strange attractors approach which demonstrated that these sequences are robust against attacks, such as spoofing or intelligent brute forcing. To assess the real-time delay and computational overhead of the algorithm, it was implemented on a Raspberry Pi board. The results demonstrated that the PRKC algorithm runs over 60% faster and requires over 40% less CPU effort per round than the conventional hashing-based schemes. In addition, it does not require any communication overhead and transmission energy.
Assessment of Factors Constraining Organic Farming Expansion in Lis Valley, Portugal

Organic farming can play an important role in rural development and food production, by reinforcing the trend toward sustainable agriculture and its purpose of ecosystem conservation. The agribusiness of organic farming is particularly relevant in family farming, given the labor availability and the short marketing circuits. The innovative techniques of organic farming, namely with soil fertility, weed and pest control, opens a wide range of possibilities in its development and extension. The expectation of organic farming profitability in small-scale family farming, supported by known successful examples, were the theme of a field study on Lis Valley Irrigation District to assess the constraints to its expansion in order to outline the procedures for the acquisition of technical knowledge, the adaptation of technologies, the support for the conversion of production models, and the specialized training of farmers for action. Results revealed that the: (i) farmer’s land structure, (ii) their mature age, (iii) low education level, and (iv) markets, are the main constrains for organic farming development. Furthermore, other uncertainties were identified, namely: (i) the certification process, (ii) the knowledge of new technologies, especially of crop protection, and (iii) the marketing problems to guaranteeing profitability. This study concludes that organic farming has significant potential for development in the Lis Valley and that the efforts and resources of the various stakeholders, namely the state, need to be harmonized to deliver effective support to farmers to promote organic farming that prioritizes: (i) rural development policies, (ii) supporting land restructuring, (iii) modernization of irrigation, (iv) stimulation of young farmers, (v) conversion and implementation of innovative technologies, (vi) the organization of farmers for better productive efficiency, and (vii) to facilitate market access.
Statistical Errors in Medical Journals (A Critical Appraisal)

Background: Importance of Statistics and its appro-priate appliance in every field of life are inevitable. Research conducted in all sciences, particularly in medicine stipulates the usage of statistics to make the results unswerving and authentic. Any research, how so ever expensive and hefty, has no worth and fails to accomplish the tasks for which it is conducted, if sta-tistics involved in it contains error. It has been attested now, that many articles published in medical journals restrain errors in them. Particularly in Pakistan, the use of statistics is not given the suitable worth, resulting many statistical flaws. Thus it has become the need of hour to investigate these errors, highlight and conse-quently make an effort to eradicate them from medical research. This study has been designed to scrutinize such errors in local medical journals of Pakistan. Study Design: Cross - sectional study design was used. Methodology: 80 research articles published in in-dexed and recognized local journals of Pakistan were reviewed. The selection of those research articles was random and those were easily and freely available on-line. Case series and case reports were excluded. Results: Descriptive statistics was only used in 32 (28.75%), inferential statistics along with the descript-tive statistics was used in 33 (41.25%) articles. Design of a study was not mentioned in 42 (52.5%) articles, in 74 (92.5%) articles there was no criteria for sample size estimation and power calculation. Wrong statis-tical analysis was done in 23 (28.75%) articles. Out of 80 articles evaluated, 57 (71.2%) articles used infe-rential statistics but did not mention whether the assu-mptions for statistical test used, met or not. Conclusion: In order to endorse medical research with authentication and reliability, the role of biosta-tistician needs to be divulged. Thus biostatistician sho-uld be taken in editorial boards or articles should be referred by the biostatisticians or statisticians for app-roval in order to keep the standards of research upgra-ded. Keywords: Statistical error, biomedical research and Statistical methods.
Access to Dental Care for a Selected Group of Children and Adolescents with ASD

Objectives: 1) to determine if children and adolescents with autism spectrum disorder (ASD) encounter difficulties accessing dental care, 2) to identify barriers that diminish access to dental care for this population. Methods: This descriptive study is based on a web-survey conducted at the Geneva Centre for Autism in Toronto between November 2008 and March 2009. Forty-nine multiple choice questions including open-ended fields were developed. Parents of children with ASD (ages 5–18) completed the survey. Results: The majority of participants visited a dentist regularly (71%) and had private dental insurance (64%). Parents/caregivers were more likely to have difficulties finding a dentist as unmarried parents (OR=3.7, P=0.075) or when their level of education was high school/less (OR=10.4, P=0.043). Conclusions: The majority of children/adolescents with ASD had access to dental care. Difficulties accessing dental care were related to family structure, parents’ education and their perception of dentists’ knowledge of ASD.