Miracle-dz/UniFAR-FTUs huggingface dataset:
Conservative Treatment with Continuous Cryotherapy as a Japanese Judo Therapy for Jones Fracture: A Case Report

Introduction: Cryotherapy has been widely used as an acute treatment for traumatic injuries. However, it is rarely continuously used for fracture treatment for several weeks, particularly for refractory fractures. Some judo therapists, who can treat traumatic injuries under the Japanese law, use cryotherapy as a continuous treatment for fractures. Herein, we report a case of Jones fracture (refractory) treated by a therapist using continuous cryotherapy. Case presentation: A 49-year-old woman had a non-transposable Jones fracture located at the metaphysis of the right 5th metatarsal from an inversion injury in the ankle. At this time, the patient had severe pain and swelling, and her walking ability was impaired. Three days after the fracture, the therapist started conservative treatment mainly using cryotherapy for the lesion part for 15 min thrice every day; splint-fixation using a hard cardboard was then performed using the standard style of the Japanese Judo therapy. Fifteen days after the fracture, the numerical rating scale (NRS) score of the patient notably decreased to 1.5 compared with the first NRS score of 10. Moreover, pain upon normal walking with full-weight bearing completely resolved, and the ankle had a full range of motion. Moreover, there was no muscle atrophy. Twenty-four days after the fracture following daily cryotherapy, the NRS score was 0, and there were no problems in the performance of activities of daily living and work. Moreover, mild running and going up and down the stairs became possible. Finally, the patient showed excellent clinical and functional results at the two-month and one-week follow-up, and the side effects of this therapy were not observed. Conclusion: This case highlights the use of cryotherapy as a continuous treatment for Jones fracture.
Controle Antecipativo por Estimativa de Carga Térmica em Vídeo

: A feedforward controller enhances thermal comfort in buildings by taking into account an estimation of the occupation’s thermal load. The air-conditioning system’s thermal load depends on the number of people in a meeting room (dimensions 3 x 5 x 3 m 3 , for up to 20 people). Feedforward control acts as soon as the variation in the people quantity is observed. Computer Vision Techniques were used to count the number of people in the room. Temperature sensors were installed in the meeting room, in neighboring room and in the external area. The PI controller rejects “conventional” disturbances in a closed loop. The feedforward controller showed an improvement of more than 10% in the temperature mean square error. Besides more than 2.5% in energy saving when compared to PI and 24% when compared to on-oﬀ.
Automatically steering cardiac catheters in vivo with respiratory motion compensation

A robotic system for automatically navigating ultrasound (US) imaging catheters can provide real-time intra-cardiac imaging for diagnosis and treatment while reducing the need for clinicians to perform manual catheter steering. Clinical deployment of such a system requires accurate navigation despite the presence of disturbances including cyclical physiological motions (e.g., respiration). In this work, we report results from in vivo trials of automatic target tracking using our system, which is the first to navigate cardiac catheters with respiratory motion compensation. The effects of respiratory disturbances on the US catheter are modeled and then applied to four-degree-of-freedom steering kinematics with predictive filtering. This enables the system to accurately steer the US catheter and aim the US imager at a target despite respiratory motion disturbance. In vivo animal respiratory motion compensation results demonstrate automatic US catheter steering to image a target ablation catheter with 1.05 mm and 1.33° mean absolute error. Robotic US catheter steering with motion compensation can improve cardiac catheterization techniques while reducing clinician effort and X-ray exposure.
Tubular lysosomes harbor active ion gradients and poise macrophages for phagocytosis

Significance Lysosomes are organelles that also act as cell-signaling hubs. They regulate functions ranging from antigen presentation to autophagy. Spherical lysosomes can spontaneously elongate into tubules in starving or inflamed immune cells. We describe a DNA-based reagent, denoted Tudor, that tubulates lysosomes in macrophages without triggering either an immune response or autophagy. Chemical imaging revealed that tubular lysosomes differ from vesicular ones in terms of their pH, calcium, and proteolytic activity. Tudor revealed a role for tubular lysosomes in that they enhance MMP9 secretion and phagocytosis in resting macrophages. The ability to tubulate lysosomes in resting immune cells without starving or inflaming them may help reveal new insights into how tubular lysosomes function. Lysosomes adopt dynamic, tubular states that regulate antigen presentation, phagosome resolution, and autophagy. Tubular lysosomes are studied either by inducing autophagy or by activating immune cells, both of which lead to cell states where lysosomal gene expression differs from the resting state. Therefore, it has been challenging to pinpoint the biochemical properties lysosomes acquire upon tubulation that could drive their functionality. Here we describe a DNA-based assembly that tubulates lysosomes in macrophages without activating them. Proteolytic activity maps at single-lysosome resolution revealed that tubular lysosomes were less degradative and showed proximal to distal luminal pH and Ca2+ gradients. Such gradients had been predicted but never previously observed. We identify a role for tubular lysosomes in promoting phagocytosis and activating MMP9. The ability to tubulate lysosomes without starving or activating immune cells may help reveal new roles for tubular lysosomes.
Effects of Grape Seed Extract Supplementation on Exercise Performance in Athletes

Editorial Reductions in O2 delivery (blood flow x O2 content) to contracting skeletal muscle can have adverse effects on physical performance. In this regard, factors that reduce blood flow can promote fatigue by reducing muscle force and/or attenuating the removal of metabolic by products of contraction [1]. Conversely, interventions that enhance O2 delivery at a given work intensity could potentially reduce muscle fatigue or delay its onset, leading to improved physical performance. Thus, identification and investigation of such interventions represents an important focus of research in sports science. One possible approach involves the study of dietary factors that may act as ergogenic aids via their actions on cardiovascular function. For example, acute supplementation with beet root juice, which is high in nitrates, has been shown to enhance cardiac output and oxygen utilization and reduce vascular resistance and blood pressure at a given sub-maximal work intensity [2,3]. These effects are indicative of increased O2 delivery to skeletal muscle.
VM placement with effective energy management in cloud using optimal VM allocation framework (OVAF)

The performance of servers at the data centers is affected when the servers are overloaded. To overcome this problem, the workload at the overloaded servers has to be redistributed to other servers which is possible with live VM migration. Live migration plays a crucial role in handling the overload at the data centers without service interruption. However, live migration also incurs some performance loss and energy overhead. The energy consumption at the data centers is a matter of utmost concern both in terms of economy and ecology. In this paper we are proposing a novel approach to find the most suitable server for VM placement. We have introduced an Optimal VM Allocation Framework (OVAF) in which the hosts at the source requests the destination for their available slots. Based on the response from the available servers, the utilization factor is calculated and the selection of appropriate destination for VM placement is done. Simulations carried out have shown 10% improvement in energy saving.
PROTOCOL: Does executive compensation predict publicly traded firms’ financial performance or inaccurate financial reporting?

Abstract This is the protocol for a Campbell review. The objectives are as follows: One goal of this systematic review is to identify whether incentive terms in CEO contracts predict firm financial performance over time; a second goal is to identify whether incentive terms in CEO contracts predict subsequent inaccurate financial reporting as manifest in restatement of accounting data due to errors or other distortions in reporting financial information.
Microplastics in the soil environment: Occurrence, risks, interactions and fate – A review

Abstract The issue of microplastic pollution emerged from the marine environment, but the terrestrial environment is estimated to receive annually 4–23 times more plastic wastes. Microplastic pollution in the soil environment has thus begun to elicit great concern. This review summarizes the observed effects of microplastic pollution on soil ecosystems as well as sorption and transport behaviors of microplastics in such environments. Microplastic pollution has been detected in various soils including agricultural/farmland, greenhouse, home garden, coastal, industrial, and floodplain soils. Microplastics affect soil physical and chemical properties, microbial and enzyme activities, and plant growth, and also pose adverse ecotoxicological effects to soil fauna. These effects depend on the concentration, size, and shape of microplastics, as well as soil texture. Microplastics are known to sorb organic and inorganic pollutants, possibly affecting the distribution of these substances in soil. Existing evidence demonstrates the negligible effect of microplastics on bioaccumulation of contaminants in soil fauna. The horizontal and vertical transport of microplastics can be facilitated by soil fauna. Pollutants associated with microplastics may disperse further following the transport of microplastics in soil. This review also highlights perspectives for future research on microplastics in soil. Graphical Abstract
Investigation on the effectiveness of two different therapeutic exercise programs in patients with chronic mechanical neck pain : a randomized controlled trial

This thesis is protected by copyright, with all rights reserved. By reading and using the thesis, the reader understands and agrees to the following terms: 1. The reader will abide by the rules and legal ordinances governing copyright regarding the use of the thesis. 2. The reader will use the thesis for the purpose of research or private study only and not for distribution or further reproduction or any other purpose. 3. The reader agrees to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.
Carbon‐Dot‐Induced Acceleration of Light‐Driven Micromotors with Inherent Fluorescence

Real‐time visualization of the positions of micro/nanomotors is highly desired for practical applications due to the complex environments that they are used in. However, most reported photocatalytic micromotors can only be tracked in transparent solutions under bright fields, which greatly limits their applications. Herein, photocatalytic micromotors based on Cu2O@carbon dot (CDot) particles with excellent fluorescent properties and precise propulsion capabilities in 3D are reported. In the fully green environment of malic acid, the Cu2O@CDot micromotors display efficient propulsion under visible light irradiation (as high as 40.85 μm s−1). In addition, the propulsion direction of the Cu2O@CDot micromotors can be effectively adjusted by changing the direction of light via positive phototaxis. Interestingly, due to the presence of CDots, these new Cu2O@CDot micromotors display excellent and stable fluorescence. This study reports the first photocatalytic micromotors with both novel fluorescence properties and excellent propulsion characteristics in biocompatible environments. Due to their excellent fluorescent properties and precise motion control, these Cu2O@CDot micromotors hold great potential to perform complex tasks across diverse practical applications.
Prospective of ischemic stroke biomarkers

Abstract Methods currently used in brain vascular disorder diagnostics are neither fast enough nor clear-out; thus, there exists a necessity of finding new types of testing which could enlarge and complete the actual panel of diagnostics or be an alternative to current methods. The discovery of sensitive and specific biomarkers of ischemic brain stroke will improve the effects of treatment and will help to assess the progress or complications of the disease. The relevant diagnosis of ischemic stroke (IS) within the first 4.5 hours after the initial symptoms allows for the initiation of treatment with recombinant tissue plasminogen activators which limits the magnitude of negative changes in the brain and which enhance the final effectiveness of therapy. The potential biomarkers which are under investigation are substances involved in the processes of coagulation and fibrinolysis, and are of molecules released from damaged vascular endothelial cells and from nerves and cardiac tissue. The analyzed substances are typical of oxidative stress, apoptosis, excitotoxicity and damage of the blood brain barrier.
Chemical composition and ruminal digestion of corn silage with Morus alba L. foliage

Chemical composition and ruminal digestion parameters were mea- sured in the silage of the whole corn plant (Zea mays L.) mixed with mulberry foliage (Morus alba L.) in ratio of 100:0, 80:20, 60:40, 40:60, 20:80 and 00:100% of fresh forage weight, respectively. The 40:60 ratio of corn: mulberry increased crude protein content (CP = 14.28%) and decreased hemicellulose (12.15%), neutral (NDF = 28.00%) and acidic (ADF = 15.85%) detergent fiber, compared to 100: 0% ratio, respectively, which led to a 21.3% increase in in vitro dry matter digestibility (IVDMD). Also ammoniacal nitrogen 7.40% (NH3-N/total N) was higher in the ratio 40:60%, with pH of 4.19 which is normal for silages, which translates the buffer activity correct of ammonia and its importance for silage fermentation stability. The correlation (r = 0.61, p < 0.001) indicated that at higher CP content, higher is IVDMD and hemicellulose (r = -0.99), ADF (r = -0.98) and NDF (r = -0.98) indicated that these fibrous compounds decreased IVDMD (p < 0.001). The regression showed that the increase in content CP (0.555%, p < 0.01) and IVDMD (0.3391%, p < 0.001) with the decrease of NDF (-0.3526%), ADF (-0.1623%) and hemicellulose (-0.1903%) (p < 0.001) in mixed mini silos, was attributed to mulberry foliage addition. It is concluded that the contribution of dry matter and nitrogen of mulberry, decreased the fiber content and increased digestibility parameters of silage when it is elaborated in ratio of 40:60 corn and mulberry, respectively.
Pluralization in sign and in speech: A cross-modal typological study

Abstract Spoken languages employ various strategies to mark the plural of nouns, the most important ones being affixation, reduplication, and zero marking; within one language, different strategies and/or different morphological markers may be used, depending on lexical, phonological, or morphological properties of the base noun. In this article we present the first cross-modal typological study of noun pluralization. A comparison of the patterns found in sign languages, in particular German Sign Language (DGS), to those described for spoken languages will show that DGS patterns with spoken languages in that (i) different plural marking strategies are available, (ii) within one strategy (reduplication) there are different types of realization, and (iii) the choice of strategy and of type crucially depend on phonological properties of the base noun, in particular, on the noun's location and movement features. The description of basic plural patterns is supplemented by a typological sketch of the use of classifiers in plural constructions and by an investigation of how and where plural is realized within the noun phrase.
Causes of Legal Action following Treatment for Varicose Veins

P K O C E D U R E S C A R R I E D O U T for the treatment of varicose veins are among the commonest in surgical practice. Although it is virtually impossible to document the numbers of such treatment episodes accurately, an estimated 100 000 procedures are performed each year in the UK. Major life or limb‘-threatening complications are rare and might be expected to result in legal action. Minor complications are more common, and the likelihood of these resulting in legal action is intimately bound up with such diverse factors as patient expectation and the patient’s perception of the eventual result.
Avaliação do trauma intracoclear causado pela inserção do feixe de eletrodos do implante coclear via fossa média em ossos temporais

Cisneros Lesser JC. Evaluation of intra cochlear trauma after cochlear implant electrode insertion through a middle fossa approach in temporal bones [thesis]. “São Paulo: Universidade de São Paulo, Faculdade de Medicina; 2016”. Introduction: In recent years, a middle fossa approach has been described for the insertion of cochlear implants, and it proved to be a reliable alternative for implantation in patients with chronic supurative otitis media, unstable mastoid cavities with recurrent otorrhea, partially ossified cochlea and in some cases of inner ear dysplasia. Until now, no research has been done to describe if this approach allows for anatomic preservation and non-traumatic insertions comparable to those through the round window. Objective: To evaluate cochlear trauma when the cochlear implant electrode is inserted through a middle fossa approach by means of histologic and imaging studies in temporal bones. Methods: 20 temporal bones retrieved before 24 hours after death were implanted through a middle cranial fossa cochleostomy in the basal turn of the cochlea. Ten received a straight electrode and 10 a perimodiolar electrode. After reducing the bone size with preservation of the inner ear structures, the temporal bones were fixed, dehydrated and embedded in an epoxy resin. CT scans were performed to determine if an adequate direction of insertion was attained, the depth of insertion and the distance between the cochleostomy and the round window. At last, the samples were polished by micro-grinding technique and microscopically visualized to evaluate intracochlear trauma. Results: The CT-scan showed an adequate intracoclear position of the electrode in all the samples. In the straight electrode group the average number of inserted electrodes was 12.3 (10 to 14) against 15.1 (1416) for the perimodiolar (U=78, p=0.0001). The median depth of insertion was significantly larger for the perimodiolar electrode group (14.4mm vs. 12.5mm U=66, p = 0.021). Only one atraumatic insertion was achieved and 70% of the samples had important trauma (grades 3 and 4). No differences were identified for the trauma grades between the two groups of electrodes. Also, there were no differences in trauma if the cochlear implants were inserted in the direction of the basal turn of the cochlea or in the direction of the middle and apical turns. Conclusions: The surgical technique that was used allowed for a proper intracochlear insertion of the electrodes in all 20 temporal bones but it does not guarantee a correct scala tympani position and carries high trauma risk for the intracochlear microstructures. Descriptors: 1.Cochlear implant; 2.Temporal bone/anatomy & histology; 3.Temporal bone/surgery; 4.Sensorineural hearing loss; 5.Sensorineural hearing loss/surgery; 6.Sensorineural hearing loss/rehabilitation; 7.Middle cranial fossa/surgery; 8.Middle cranial fossa/anatomy & histology; 9.Cadaver; 10.Humans; 11.Computed tomography; 12.Inner ear; 13.Cochlea/damage; 14.Implanted electrodes/adverse effects.
DHX9-dependent recruitment of BRCA1 to RNA is required to promote DNA end resection in homologous recombination

DExD/H-box helicase 9 (DHX9/RNA helicaseA) is ubiquitously expressed ATP-dependent helicase that unwinds a variety of complex DNA and RNA secondary structures, suggesting it might have a role in DNA replication and the repair of DNA damage. Here we identify a pivotal role for DHX9 in homologous recombination (HR). Cells that are deficient in DHX9 are impaired in the generation of single stranded DNA (ssDNA) by DNA end resection. Consequently these cells fail to recruit RPA and RAD51 to sites of DNA damage and are hypersensitive to treatment with the DNA damaging agents camptothecin and Olaparib. A critical early step in the initiation of HR is the recruitment of BRCA1 mediator protein to DNA damage to promote DNA resection. We show here that recruitment of BRCA1 to DNA damage foci is dependent on its interaction with DHX9 to form the BRCA1-D complex, which binds to nascent RNA. Together our data identify a pivotal role for DHX9 in homologous recombination and highlight the important contribution of RNA in the recruitment of BRCA1 to DNA damage for the repair of DNA breaks
Personality and socio-demographic correlates of proffesional burnout in a group of firemen from the Lublin Province

Introduction. The work of firemen is characterised by many dangers. These include actions that may often have a negative impact on health and even life. Frequent exposure to emotionally encumbering events can lead, among others, to symptoms of professional burnout. Objective. The aim of the study is to present the relationship between personality traits, self-efficacy, stress level and the components of occupational burnout in a group of firemen from the Lublin Province. Materials and Method. The study involved 120 firemen aged 22–52, working in Biłgoraj and Zamość. The research tools were: an authorial socio-demographic survey, the General Self-Efficacy Scale (GSES), Perceived Stress Scale (PSS-10), NEOFFI Personality Inventory, and the Maslach Burnout Inventory (MBI). Results. Self-research analyses confirmed the existence of a link between personality traits, levels of stress, self-esteem and components of burnout in a group of surveyed firemen. The increase in the level of conscientiousness determined the increase in the sense of personal accomplishments. Stress reached statistical significance as a predictor of emotional exhaustion and depersonalization. With the improvement of the financial situation and the quality of cooperation between the respondents and their superiors/colleagues, there is a growing sense of self-effectiveness and the level of personal accomplishments. As they deteriorate, emotional exhaustion increases. Adres do korespondencji: Agata Madej, Instytut Medycyny Wsi, Lublin, Jaczewskiego 2, 20-090, Lublin, Polska E-mail: madej_agata@interia.pl Nadesłano: 25.09. 2019; Zaakceptowana do druku: 27.12. 2019; Publikacja on line: 31.01. 2020 Medycyna Ogólna i Nauki o Zdrowiu www.monz. pl OLINE FRST OLINE FRST OLINE FRST OLINE FRST Agata Madej. Korelaty osobowościowe i socjodemograficzne wypalenia zawodowego w grupie funkcjonariuszy straży pożarnej z terenu województwa lubelskiego Conclusions. The factors protecting firemen against professional burnout include cooperation with the supervisor/ co-workers, shift work system, level of satisfaction with the performance of work, and the amount of remuneration received. An important factor is also an increase in awareness of firemen concerning the possibility of using psychological assistance in difficult situations.