Miracle-dz/UniFAR-FTUs huggingface dataset:
PRE-1 Revealed Previous Unknown Introgression Events in Eurasian Boars during the Middle Pleistocene

Abstract Introgression events and population admixture occurred among Sus species across the Eurasian mainland in the Middle Pleistocene, which reflects the local adaption of different populations and contributes to evolutionary novelty. Previous findings on these population introgressions were largely based on extensive genome-wide single-nucleotide polymorphism information, ignoring structural variants (SVs) as an important alternative resource of genetic variations. Here, we profiled the genome-wide SVs and explored the formation of pattern-related SVs, indicating that PRE1-SS is a recently active subfamily that was strongly associated with introgression events in multiple Asian and European pig populations. As reflected by the three different combination haplotypes from two specific patterns and known phylogenetic relationships in Eurasian boars, we identified the Asian Northern wild pigs as having experienced introgression from European wild boars around 0.5–0.2 Ma and having received latitude-related selection. During further exploration of the influence of pattern-related SVs on gene functions, we found substantial sequence changes in 199 intron regions of 54 genes and 3 exon regions of 3 genes (HDX, TRO, and SMIM1), implying that the pattern-related SVs were highly related to positive selection and adaption of pigs. Our findings revealed novel introgression events in Eurasian wild boars, providing a timeline of population admixture and divergence across the Eurasian mainland in the Middle Pleistocene.
Tumour induced osteomalacia: a diagnostic challenge and its implications in orthopaedic surgery

Tumor-induced osteomalacia (TIO) is a paraneoplastic phenomenon which encompasses a wide array of clinical features ranging from musculoskeletal pain to pathological fractures. An excess of fibroblast growth factor 23 (FGF23) is produced which is a parahormone with its target receptors in proximal convoluted tubules of glomeruli. This results in decreased blood phosphate levels and decreased hydroxylation of 25-OH vitamin-D, ultimately leading to osteomalacia. Compliance with medical treatment is unsatisfactory and tedious owing to repeated dosing schedules and overwhelming side effects. Surgical excision of the lesion is the only suitable treatment.
Proposed Business Strategy for Publishing Company (Case Study: CV Gema Usaha in Solo)

CV Gema Usaha is a company running in book publishing industry, provides school books for junior high school, high school, and vocational school in Indonesia. For the past 3 years (2016-2018) the company has been suffering from some problems that affect the business sustainability. Looking from the internal perspectives, the company has high inventory, lacking in human resources, and high receivables which affect the business at CV Gema Usaha. This condition causes a value-reducing for the company. To be able to survive in the publishing industry, improvements need to be made to their business strategy. Business strategy improvement is proposed based on internal and external analysis. An evaluation of the business model currently applied is also carried out by analyzing the current business model canvas. This study uses qualitative methods using primary data and secondary data. The results of internal and external analysis produce SWOT analysis which is then used to propose strategic solutions in the form of TOWS matrix and new business model. The strategy proposed for the company is to adapt the integrated cost leadership and differentiation business strategy, and shift the publishing business model from a conventional publishing to a base on demand model, by implementing the long tail business model that is equipped with a multi-sided platform. This strategy is expected to solve the main problem of the company namely high inventories, low in cash, and limited human resources.
A Machine Learning Integrated Portfolio Rebalance Framework with Risk-Aversion Adjustment

We propose a portfolio rebalance framework that integrates machine learning models into the mean-risk portfolios in multi-period settings with risk-aversion adjustment. In each period, the risk-aversion coefficient is adjusted automatically according to market trend movements predicted by machine learning models. We employ Gini’s Mean Difference (GMD) to specify the risk of a portfolio and use a set of technical indicators generated from a market index (e.g., S&P 500 index) to feed the machine learning models to predict market movements. Using a rolling-horizon approach, we conduct a series of computational tests with real financial data to evaluate the performance of the machine learning integrated portfolio rebalance framework. The empirical results show that the XGBoost model provides the best prediction of market movement, while the proposed portfolio rebalance strategy generates portfolios with superior out-of-sample performances in terms of average returns, time-series cumulative returns, and annualized returns compared to the benchmarks.
Parental Declaration of Adverse Event Following Immunization in a Cross-Sectional Study in Poland

Vaccines are a well-known and effective preventive measure in communicable diseases. However, like any medical product, vaccines can cause some adverse effects. With increasing population awareness, the number of reported events related to vaccination has increased. Aim: The aim of the study was to assess the frequency and type of reported adverse events following childhood immunization (AEFI), and to recognize the determinant of their occurrence related with a socio-demographic situation, parental knowledge, and/or opinions on vaccinations. Material and Methods: The self-administrated questionnaire was distributed to a group of 3000 random parents or legal guardians living in the Silesian Voivodship (the southern part of Poland) in 2016. The response rate was eventually 41.3% from 1239 participants. Both, the number of children and the percentage of vaccinations given in the studied region, was representative for Poland as a whole. Results: Approximately one-third (32%) of surveyed parents declared the occurrence of AEFI in their children. The most frequently declared AEFIs were: redness, pain, swelling at the injection site (27%), and fever (24.9%). The frequency of reported AEFI was associated with a higher level of parental education and the number of vaccinations given. A negative attitude toward vaccination and the belief that vaccination is unsafe were associated with a higher number of reported AEFI. Conclusions: The results obtained confirmed that the number of declared mild and moderate AEFI is related to a lower parental educational level and is associated with a better experience as a consequence of a higher number of vaccinations given. Frequent AEFI reporters represent negative attitudes toward vaccinations. Further investigation with the exact surveillance system is needed to improve parental trust in vaccination safety.
The Increasing Inequality of Wealth in China

The inequality of wealth in China has increased rapidly in recent years. Prior to 1978 all Chinese households possessed negligible wealth. China therefore presents a fascinating case study of how inequality of household wealth increases with economic reforms, marketization, and capital accumulation. Wealth inequality and its growth are measured and decomposed by using data from the CHIP 2002 and 2013 survey datasets. Techniques for estimating the top tail of the income distribution by using a Pareto approximation are applied to measure the sensitivity of wealth inequality to plausible assumptions about the underrepresentation of the wealthy and underreporting by the wealthy. The rising wealth inequality is explained in terms of the relationships between income and wealth, house price inflation, and differential savings.
Role of N-Acetylcysteine in the Treatment of Acute Nonacetaminophen, Nonalcoholic and Nonviral Hepatitis: A Meta-analysis

Abstract Introduction N-acetylcysteine (NAC) has been extensively investigated for the use in acetaminophen and alcoholic hepatitis and is indicated in acetaminophen overdose. Studies assessing the effect of NAC on other forms of acute hepatitis in adult patients are limited and therefore here we aimed at evaluating the effect of NAC on survival in nonacetaminophen, nonalcoholic and nonviral hepatitis in adults. Methods A comprehensive literature search up to September 2019 was completed for randomized controlled trials (RCTs) comparing NAC to placebo in the management of acute nonacetaminophen, nonalcoholic and nonviral hepatitis. Studies with insufficient data, non-RCT or nonprospective design, paediatric studies and studies with no comparator were excluded. Study selection, quality assessment and data extraction were independently performed by two co-authors. Primary outcome was survival. Secondary outcomes were an increase in infection rate. We used random model Mantel–Haenszel meta-analysis with Cochrane risk of bias to assess the quality of included studies. The recommendation was presented using the GRADE framework. Results Seven out of 42 retrieved studies were included. Study population included patients with post-liver transplant, postsurgical, hypoxia-induced, ischemic and other nonalcoholic hepatitis. There was no difference in overall survival between NAC and placebo (odds ratio [OR] 0.95 [0.55 to 1.62]) in seven studies including 1033 patients. Furthermore, there was no difference in the rate of infection between NAC and placebo (OR 0.87 [0.43 to 1.79]). Random model analysis was used to adjust the effect of statistically significant heterogeneity in both analyses (P = 0.02). Lack of blinding in one study was found as a possible source of heterogeneity. Conclusions NAC does not improve overall survival or the rate of infection in patients with acute nonacetaminophen, nonalcoholic and nonviral hepatitis as compared to placebo and should not be recommended in such setting which may even delay a transplant evaluation (level of evidence: 2a, GRADE of recommendation: B).
An Optimization Technique of the 3D Indoor Map Data Based on an Improved Octree Structure

The construction and retrieval of indoor maps are important for indoor positioning and navigation. It is necessary to ensure a good user experience while meeting real-time requirements. Unlike outdoor maps, indoor space is limited, and the relationship between indoor objects is complex which would result in an uneven indoor data distribution and close relationship between the data. A data storage model based on the octree scene segmentation structure was proposed in this paper initially. The traditional octree structure data storage model has been improved so that the data could be backtracked. The proposed method will solve the problem of partition lines within the range of the object data and improve the overall storage efficiency. Moreover, a data retrieval algorithm based on octree storage structure was proposed. The algorithm adopts the idea of “searching for a point, points around the searched point are within the searching range. ” Combined with the octree neighbor retrieval methods, the closure constraints are added. Experimental results show that using the improved octree storage structure, the retrieval cost is 1/8 of R-tree. However, by using the neighbor retrieval, it improved the search efficiency by about 27% on average. After adding the closure constraint, the retrieval efficiency increases by 25% on average.
The Effect of Noble Metal (M: Ir, Pt, Pd) on M/Ce2O3-γ-Al2O3 Catalysts for Hydrogen Production via the Steam Reforming of Glycerol

A promising route for the energetic valorisation of the main by-product of the biodiesel industry is the steam reforming of glycerol, as it can theoretically produce seven moles of H2 for every mole of C3H8O3. In the work presented herein, CeO2–Al2O3 was used as supporting material for Ir, Pd and Pt catalysts, which were prepared using the incipient wetness impregnation technique and characterized by employing N2 adsorption–desorption, X-Ray Diffraction (XRD), Temperature Programmed Reduction (TPR), Temperature Programmed Desorption (TPD), X-ray Photoelectron Spectroscopy (XPS) and Transmission Electron Microscopy (TEM). The catalytic experiments aimed at identifying the effect of temperature on the total conversion of glycerol, on the conversion of glycerol to gaseous products, the selectivity towards the gaseous products (H2, CO2, CO, CH4) and the determination of the H2/CO and CO/CO2 molar ratios. The main liquid effluents produced during the reaction were quantified. The results revealed that the Pt/CeAl catalyst was more selective towards H2, which can be related to its increased number of Brønsted acid sites, which improved the hydrogenolysis and dehydrogenation–dehydration of condensable intermediates. The time-on-stream experiments, undertaken at low Water Glycerol Feed Ratios (WGFR), showed gradual deactivation for all catalysts. This is likely due to the dehydration reaction, which leads to the formation of unsaturated hydrocarbon species and eventually to carbon deposition. The weak metal–support interaction shown for the Ir/CeAl catalyst also led to pronounced sintering of the metallic particles.
Study on the Influence of Typical Plant Roots on the Stability of Slope in the Hilly Areas of the Lower Yangtze River

Plant roots have a positive effect on shallow landslides on slopes. In order to study the influence of typical vegetation on the slope stability in the hilly area of the lower reaches of the Yangtze River, the triaxial test was used to obtain the shear strength parameters of the root-soil complex of typical vegetation of Salix babylonica and Pterocarya stenoptera in the hilly areas of the lower Yangtze River. On this basis, the slope stability calculation model based on the limit element theory is established. The safety factor of the reinforced slope was calculated under three kinds of slope conditions (30°, 39°, 45°), and the influence of root type, position and depth on the slope stability was analyzed. Studies have shown that different types of plant roots mainly affect the stability of slope by enhancing the cohesion of soil. The improvement of slope stability by root system is related to the reinforcement position of root system. The effect of vegetation root on the reinforcement effect of slope The range is roughly in the vicinity of the sliding surface of the slope, and the closer to the sliding surface, the better. Plant roots have a peak effect on the slope at a certain depth, not as deep as possible. This paper provides a reference for studying the influence of vegetation on slope stability, and provides a reference for guiding the slope greening in the hilly areas of the lower Yangtze River.
Social Media Use and Participation in Dueling Protests: The Case of the 2016–2017 Presidential Corruption Scandal in South Korea

This study examines how citizens’ social media use may have influenced their participation in highly polarizing protests during the 2016–2017 corruption scandal in South Korea. As social media users mobilize politically by acquiring varied political information from other users, social media use created more incentives for citizens to participate in both pro- and anti-impeachment protests during the scandal. Given that social media is an important arena for political activism, participation in rival protests also influences many motivated protesters to strengthen their side’s voices online. Thus, protests may increase citizens’ political use of social media. Our empirical analysis suggests that social network service use does not influence citizens’ political activities in a unidirectional manner. We have found that social media use and participation in rival protests reciprocally influence each other.
Nanofillers for Food Packaging: Antimicrobial Potential of Metal-based Nanoparticles

Recently, numerous studies on the packaging of nanomaterials for foods underline the significant function of nanofillers in the manufacturing of innovative nanocomposites based on polymer or biopolymer matrices. It is evident in the literature that nanofillers exhibit effective characteristics such as antimicrobial potential, barrier, mechanical, and thermal properties. However, the exact mechanisms regulating the occurrence of the antimicrobial activity of nanofillers are only hypothesized, with the literature containing controversies regarding the mechanisms of nanofiller-induced toxicity. The objective of this review is to highlight several types of nanofillers, especially inorganic nanofillers that can be used along with different polymers or biopolymers to form innovative food packaging materials. The antimicrobial potential of metal-based nanofillers is also discussed in the second part of the review. Even though numerous reports on polymer or biopolymer nanomaterial applications in food packaging are available, the purpose described in those reviews has not been aimed in this article, as a smaller number of reviews have approached food packaging nanomaterials in the way as done in this review article. It is expected that the information contained in this paper will complement previous reports, and open new vistas for explorers to apply nanofillers in the functional food packaging area.
Characteristics and performance of aerobic granulation seeded with anaerobic bioflocs for treatment of domestic wastewater

In the present study, aerobic granular sludge was developed using a combination of anaerobic bioflocs and activated sludge. The granulation process and removals of organic compound (COD and ammoniacal nitrogen) were observed for 140 days of experimental period. The granulation process occurred after 30 days of the experiments, indicated by the decrease in sludge volume index (SVI) and increase of biomass concentration. The COD and ammoniacal nitrogen removal efficiencies were 67% and 72%, respectively. Mature aerobic granules were developed with diameter ranging from 4 to 6 mm with excellent settling velocity at 75 m/h. The results indicated the possibility to use anaerobic bioflocs as seeding to develop aerobic granular sludge for domestic wastewater treatment.
Transnational networks of the Theatre of the Oppressed

This work reflects on how the transnational networks of the Theatre of the Oppressed (TO) contributed to its institutionalization and permanence as one of the most practiced theatrical methodologies worldwide. In order to understand the expansion of the method developed by Augusto Boal as a transnational network, the article first defines the terms ‘ institutionalization ’ and ‘ network ’ , before providing a brief review of its history, its adaptation to the cultural policies in France and Brazil, and the importance of the TO Centres in this process. The ability of the method to adapt to the most diverse contexts, cultures and especially to the social development field demonstrate that, more than just circulating a theatrical method, the global network of the Theatre of the Oppressed reveals itself as a vehicle for the circulation of policies connected to the idea of cultural democracy.
Determination of vancomycin, linezolid and daptomycin resistance among Eenterococcus isolates from a tertiary care hospital

Introduction: The clinical importance of the genus Enterococcus species relates to its intrinsic antibiotic resistance. Synergistic activity of penicillin and aminoglycosides against Enterococcusis preferred treatment. However, Infectious Diseases Society of America (IDSA) recommends usage of linezolid and daptomycin against emerging vancomycin resistant Enterococcus(VRE) isolates. In this study, we sought to measure the prevalence of vancomycin, linezolid and daptomycin resistance in Enterococcus clinical isolates from patients in a tertiary hospital of Western Maharashtra. Materials and Methods: A total of 363 clinical isolates of Enterococcusspecies isolated from different clinical samples over the last three years and three months study period were analyzed for antibiotic susceptibility pattern against vancomycin, linezolid and daptomycin. Results: Study demonstrated low prevalence of vancomycin (4.95%) and linezolid resistance (1.10%) among Enterococcus clinical isolates. Combined resistance to vancomycin and linezolid was also noted in few isolates. No daptomycin resistance was detected in this study, however in vitro daptomycin susceptible and vancomycin heteroresistance isolates may not respond to daptomycin monotherapy. Conclusion: Our study, demonstrated relatively low prevalence of vancomycin and linezolid resistance, but emergence of combined newer drug resistance in Enterococcus species is cause of concern and reiterates the importance of importance of judicious use of antibiotics. Keywords: VRE, Linezolid, Daptomycin, E test.
Improvement of “Text Steganography Based on Unicode of Characters in Multilingual” by Custom Font with Special Properties

Since computer utilization is expanding, for both social and trade ranges, secure communications through channels got to be an exceptionally critical issue. Information hiding away could be a strategy to get a secure communication medium and securing the data amid transmission. Text documents have very less redundant information as compared to the images and audio, therefore, text steganography is most challenging. This paper aims to improve “text steganography based on Unicode of characters in multilingual” by design new font with special properties for purposes of hiding data. Furthermore, this method based on making the same glyphs for the multiple codes, the Set of High-Frequency Letters called SHFL in the English language was chosen for the embedding process. The hiding method replaces the code of English symbol with other code that has the same glyph exactly. Two bits are hidden at once, utilizing glyph1 for hiding 00 and utilizing glyph2, glyph3, and glyph4 for hiding 01, 10, and 11. The improvement increases the steganography capacity, transparency and improves the security and robustness of the text stego file.
Mapping the Potential Distribution of Major Tick Species in China

Ticks are known as the vectors of various zoonotic diseases such as Lyme borreliosis and tick-borne encephalitis. Though their occurrences are increasingly reported in some parts of China, our understanding of the pattern and determinants of ticks’ potential distribution over the country remain limited. In this study, we took advantage of the recently compiled spatial dataset of distribution and diversity of ticks in China, analyzed the environmental determinants of ten frequently reported tick species and mapped the spatial distribution of these species over the country using the MaxEnt model. We found that presence of urban fabric, cropland, and forest in a place are key determents of tick occurrence, suggesting ticks were likely inhabited close to where people live. Besides, precipitation in the driest month was found to have a relatively high contribution in mapping tick distribution. The model projected that theses ticks could be widely distributed in the Northwest, Central North, Northeast, and South China. Our results added new evidence on the potential distribution of a variety of major tick species in China and pinpointed areas with a high potential risk of tick bites and tick-borne diseases for raising public health awareness and prevention responses.