Miracle-dz/UniFAR-FTUs huggingface dataset:
Genotypic and phenotypic characterization of a large, diverse population of maize near-isogenic lines.

Genome wide association studies can identify quantitative trait loci (QTL) putatively underlying traits of interest, and nested association mapping can further assess allelic series. Near-isogenic lines (NILs) can be used to characterize, dissect, and validate QTL, but the development of NILs is costly. Previous studies have utilized limited numbers of NILs and introgression donors. We characterized a panel of 1,270 maize NILs derived from crosses between 18 diverse inbred lines and the recurrent inbred parent B73, referred to as the nested NILs (nNILs). The nNILs were phenotyped for flowering time, height, and resistance to three foliar diseases and genotyped with genotyping-by-sequencing. Across traits, broad-sense heritability (0.4-0.8) was relatively high. The 896 genotyped nNILs contain 2,638 introgressions, which span the entire genome with substantial overlap within and among allele donors. Genome wide association with the whole panel identified 29 QTL for height and disease resistance with allelic variation across donors. To date, this is the largest and most diverse publicly available panel of maize NILs to be phenotypically and genotypically characterized. The nNILs are a valuable resource for the maize community, providing an extensive collection of introgressions from the founders of the maize nested association mapping population in a B73 background combined with data on six agronomically important traits and from genotyping-by-sequencing. We demonstrate that the nNILs can be used for QTL mapping and allelic testing. The majority of nNILs had four or fewer introgressions and could readily be used for future fine mapping studies.
Chitotriosidase: a marker and modulator of lung disease

Chitotriosidase (CHIT1) is a highly conserved and regulated chitinase secreted by activated macrophages; it is a member of the 18-glycosylase family (GH18). CHIT1 is the most prominent chitinase in humans, can cleave chitin and participates in the body's immune response and is associated with inflammation, infection, tissue damage and remodelling processes. Recently, CHIT1 has been reported to be involved in the molecular pathogenesis of pulmonary fibrosis, bronchial asthma, COPD and pulmonary infections, shedding new light on the role of these proteins in lung pathophysiology. The potential roles of CHIT1 in lung diseases are reviewed in this article. This is the first review of chitotriosidase in lung disease http://bit.ly/2LpZUQI
Génétique et adaptation chez les poissons: domestication, résistance au stress et adaptation aux conditions de milieu

Les variations genetiques de l'adaptation au milieu d'elevage chez les poissons sont un objet d'etude important dans le cadre des problematiques liees au bien-etre en elevage. Trois aspects principaux sontdistingues. Tout d'abord la question de la domestication, importante car encore en cours ou a faire sur beaucoup d'especes : les poissons domestiques se montrent mieux adaptes a l'elevage (plus aptes a se nourrir, moins stressables), mais perdent des comportements utiles en milieu naturel (fuite devant les predateurs). Ensuite la selection pour la resistance aux conditions stressantes : cette selection est efficace et semble avoir au moins pour partie des effets comparables a la domestication. Enfin, l'adaptation aux conditions de milieu et d'elevage, dont la composante genetique semble relativement importante. Il semble possible d'apres l'ensemble de ces donnees de selectionner des animaux qui seront mieux adaptes a leur milieu d'elevage. Cependant, la sensibilite des poissons a leur milieu et la variabilite de ces milieux impliquent des approches integrant les interactions genotype-milieu dans l'etude de l'effet des pratiques d'elevage sur l'adaptation des animaux.
Pilot field studies on insect pathogenic fungi to control mirid pests of apples in Norway.

In a pilot field study conducted in an apple orchard in Hardanger (Western Norway) in two succesive years both Beauveria bassiana and Metarhizium anisopliae were applied to apple trees just after hatching of mirid nymphs in spring. Both predatory, omnivorous and principally plant-pathogenic species of mirids were collected, and all groups of species were infected by B. bassiana or M. ansiopliae in treated plots. B. bassiana and M. anisopliae were also found on some individuals in non treated control plots the second year. M. anisopliae was more predominant in 2006, B. bassiana in 2007. Mirids were also observed for natural occurrence of parasitoids, and parasitoids were found both years.
Baculovirus biopesticides: an overview.

Baculoviruses have shown to be a good tool for insect pest control. Numerous natural baculoviruses have been used as biopesticides worldwide as they are naturally occurring pathogens, highly specific with limited host range, and without lethal effects on non-target organisms. Slow speed of kill of wild-type baculoviruses when compared to chemical insecticides is a serious disadvantage that has promoted the development of large number of recombinant baculoviruses, mainly with genes encoding insect-specific toxins from scorpions or spiders, which kill insects faster than the parent wild-type virus. However, uptill today no recombinant baculovirus-based pesticides are commercially available. For the expansion of baculovirus pesticides some drawbacks have to be overcome. Current methods for large scale in vitro production have to be improved in order to circumvent their technical limitations, and developments of new and more effective additives to improve the stability of baculoviruses in pesticide formulation are needed. Nonetheless, recombinant baculoviruses are expected to strongly contribute to the expansion of baculovirus pesticides use in the next future, as the negative social perception of genetically modified organisms, including genetically modified ba culoviruses, decreases.
The Unrealised Potential for Predicting Pregnancy Complications in Women with Gestational Diabetes: A Systematic Review and Critical Appraisal

Gestational diabetes (GDM) increases the risk of pregnancy complications. However, these risks are not the same for all affected women and may be mediated by inter-related factors including ethnicity, body mass index and gestational weight gain. This study was conducted to identify, compare, and critically appraise prognostic prediction models for pregnancy complications in women with gestational diabetes (GDM). A systematic review of prognostic prediction models for pregnancy complications in women with GDM was conducted. Critical appraisal was conducted using the prediction model risk of bias assessment tool (PROBAST). Five prediction modelling studies were identified, from which ten prognostic models primarily intended to predict pregnancy complications related to GDM were developed. While the composition of the pregnancy complications predicted varied, the delivery of a large-for-gestational age neonate was the subject of prediction in four studies, either alone or as a component of a composite outcome. Glycaemic measures and body mass index were selected as predictors in four studies. Model evaluation was limited to internal validation in four studies and not reported in the fifth. Performance was inadequately reported with no useful measures of calibration nor formal evaluation of clinical usefulness. Critical appraisal using PROBAST revealed that all studies were subject to a high risk of bias overall driven by methodologic limitations in statistical analysis. This review demonstrates the potential for prediction models to provide an individualised absolute risk of pregnancy complications for women affected by GDM. However, at present, a lack of external validation and high risk of bias limit clinical application. Future model development and validation should utilise the latest methodological advances in prediction modelling to achieve the evolution required to create a useful clinical tool. Such a tool may enhance clinical decision-making and support a risk-stratified approach to the management of GDM. Systematic review registration: PROSPERO CRD42019115223.
Bats of the hardwood ecosystem experiment before timber harvest: assessment and prognosis

Before experimental harvest of the Yellowwood (YW) and Morgan-Monroe (MM) State Forests (Indiana) as part of the Hardwood Ecosystem Experiment, bats were sampled using mist nets at four locations in MM and five locations in YW during each summer 2006 through 2008. Netting locations were adjacent to forest stands scheduled for experimental manipulations following conclusion of netting in 2008. This effort produced 342 bats (in order of abundance): northern myotis (Myotis septentrionalis), eastern red bat (Lasiurus borealis), big brown bat (Eptesicus fuscus), Indiana myotis (M. sodalis), little brown myotis (M. lucifugus), tri-colored bat (Perimyotis subflavus), hoary bat (L. cinereus), and silver-haired bat (Lasionycteris noctivagans). These data provide a baseline to understand how bats are affected by short- and long-term forest manipulations initiated in summer 2008.
Google OSS-Fuzz

Im Jahr 2016 hat Google das sogenannte OSS-Fuzz Programm angekundigt, welches sich zum Ziel gemacht hat, ausgewahlte Open Source Projekte sicherer zu machen. Dazu wird die Moglichkeit angeboten, die enorme Rechenleistung der Google Infrastruktur fur kontinuierliches Fuzzing, inklusive ubersichtlichem Reporting, zu nutzen. Die Open Source IPSec Umsetzung strongSwan wird an der HSR entwickelt und weltweit eingesetzt. Fur eine Software im Sicherheitsbereich ist es besonders wichtig, die Anzahl an Fehlern im Code so gering wie moglich zu halten. Fuzzing ist eine gute Moglichkeit, latente Fehler zu entdecken und somit die Codequalitat zu steigern. Fur das Fuzzing wurde libFuzzer eingesetzt, da es zu diesem Zeitpunkt die einzige von Google unterstutze Fuzzing Engine ist. Als ein vielversprechendes Fuzz Target stellte sich der Zertifikatsparser heraus, fur welchen sich ein Fuzz Target relativ leicht umsetzen liess. Das Fuzzing wurde zuerst lokal getestet, um Erfahrungen im Umgang mit der Nutzung von libFuzzer zu sammeln und dabei Anderungen, welche im strongSwan Build Prozess notig sind, aufzudecken. Anschliessend wurde das Fuzzing auf die Google Infrastruktur verlagert, um den Code auf Herz und Nieren zu testen. Ein Resultat dieser Arbeit ist die Erkenntnis uber die Integration von strongSwan in das Google OSS-Fuzz Projekt und auf welche Stolpersteine dabei besonders geachtet werden muss. Des Weiteren sind beim Fuzzing selbst einige Fehler unterschiedlicher Tragweite im Code von strongSwan aufgedeckt worden, welche bereits behoben und in Form von Patches wieder eingeflossen sind. Somit ist das Hauptziel des Fuzzings, die Verbesserung der Codequalitat, zu einem Teil bereits erreicht worden.
Lysophospholipid Receptors: Signaling and Biochemistry

Find the secret to improve the quality of life by reading this lysophospholipid receptors signaling and biochemistry. This is a kind of book that you need now. Besides, it can be your favorite book to read after having this book. Do you ask why? Well, this is a book that has different characteristic with others. You may not need to know who the author is, how well-known the work is. As wise word, never judge the words from who speaks, but make the words as your good value to your life.
Preferential anti-proliferative activity of Varthemia iphionoides (Chiliadenus iphinoides)

The present study was aimed at investigating the anti-cancer properties of the unique chemotype of Varthemia iphionoides (V. iphionoides) growing in the Judaea region (Israel). Specifically, we determined the effects of the crude ethanolic extract of V. iphionoides on the growth and viability of human cancer cell lines (SKOV3 ovarian carcinoma cells, BG melanoma cells, A549 lung cancer cells, and HL-60 myeloblastic leukemia cells). We found that the extract exhibited much stronger in vitro anti-leukemic effects on the HL-60 cells than the other cell lines tested. Importantly, both polyphenol- and flavonoid-containing fractions prepared from the extract significantly reduced the proliferation of HL-60 cells, but only the flavonoid fraction produced cytotoxic effects as well. These results suggest that V. iphionoides extract and its active components have potential therapeutic and/or preventive activity against acute myeloid leukemia.
Inhibition of Listeria monocytogenes by Bacteriocin-Producing Pediococcus During the Manufacture of Fermented Semidry Sausage 1.

A bacteriocin-producing Pediococcus species inhibitory to Listeria monocytogenes was used to manufacture fermented semidry sausage. Separate 13.6 kg batches of a commercial summer sausage formulation were inoculated to contain an initial level of 106 cells/g of Listeria monocytogenes Scott A. In each of two independent studies, an ca. 2 log10 CFU/g reduction of L. monocytogenes occurred over the fermentation period, as compared to a less than 1 log10 CFU/g reduction in sausage fermented with a non-inhibitory Pediococcus strain. Inactivation of L. monocytogenes was also observed in one study where adequate acid production did not occur (pH>5.5), indicating that bacteriocin production occurred independently of carbohydrate fermentation. Following heating to an internal temperature of 64.4°C and storage up to 2 weeks, 9 of 90 sausages sampled were positive for Listeria . Recovery was intermittent and did not indicate that the bacteriocin was effective in eliminating L. monocytogenes that had survived the heating process.
Ceric ion initiated graft copolymerization of Insoluble potato starch with acrylic acid

The graft copolymers of insoluble granular potato starch with acrylic acid (AA) were synthesized using ceric ammonium nitrate (CAN) for initiation. The effect of concentration of initiator, concentration of monomer, polymerization time, reaction temperature, material-to-liquor ratio and presence of alcohol in the reaction medium were studied and optimum conditions are defined. The formation of graft copolymers was confirmed using the method of gravimetric estimation. The grafting parameters calculated are reported.
Desenvolvimento de marcadores microssatélites e sua aplicação em populações de Melanophryniscus dorsalis (Anura: Bufonidae)

9 INTRODUÇÃO GERAL . 11 O Gênero Melanophryniscus . 12 Melanophryniscus dorsalis (Mertens, 1933) . 13 Dispersão, Isolamento por Distância e Barreiras ao Fluxo Gênico . 16 Formação e características da Planície Costeira do sul do Brasil . 18 Marcadores Moleculares . 20 OBJETIVOS . 22 CAPÍTULO I Development of microsatellite markers for an endangered red-bellied toad, Melanophryniscus dorsalis (Bufonidae) . 23 Abstract . 24. 24 Acknowledgements . 27 References . 27 TABLE . 29 CAPÍTULO II Genetic diversity and population structure in an endemic threatened red-bellied toad on a highly fragmented habitat, southern Brazil . 30 Abstract . 31. 3
Molecular evolution of viruses : past and present : evolution of viruses by acquisition of cellular RNA and DNA

Evolution of Viruses by Acquisition of Cellular RNA or DNA Nucleotide Sequences and Genes: An Introduction Y. Becker. Part A: Virus Genes Acquired to Evade the Host Immune Responses. Immunomodulatory Functions Encoded by the E3 Transcription Unit of Adenoviruses H. -G. Burgert, J.H. Blusch. Immune Escape by Hepatitis B Viruses U. Protzer, H. Schaller. MHC Class I-Subversive Gene Functions of Cytomegalovirus and Their Regulation by Interferons - An Intricate Balance C. Benz, H. Hengel. Part B: Acquisition of Cellular and Viral Genes by Herpes and Iridoviruses. Marek's Disease Herpesvirus Transforming Protein MEQ: A c-Jun Analogue with an Alternative Life Style J.-L. Liu, H. -J. Kung. Herpesvirus Homologues of Cellular Genes M. Raftery, et al. Iridovirus Homologues of Cellular Genes - Implications for the Molecular Evolution of Large DNA Viruses C.A. Tidona, G. Darai. Part C: Poxvirus Gene Homologues of Cellular Genes. Sequence and Functional Analysis of a Homolog of Interleukin-10 Encoded by the Parapoxvirus Orf Virus Genes S.B. Fleming, et al. Myxoma Virus Expresses a TNF Receptor Homolog with Two Distinct Functions X. Xu, et al. Poxvirus Homologues of Cellular Genes J.J. Bugert, G. Darai.
The elusive minimum viable population size for white sturgeon

Abstract Damming of large rivers in the U.S. Pacific Northwest and Canada has divided the historical population of white sturgeon Acipenser transmontanus into more than 36 fragmented populations, few of which are thriving. We now face the challenge of managing these populations to avoid extirpation. Two goals of this study were to identify extinction thresholds related to small size and inadequate habitat for this species. The minimum viable population size (MVP) is the threshold size above which populations support recruitment and grow and below which populations fail to support recruitment and decline. We estimated a single, cross-population MVP using data from multiple populations and quantile regression, which removed the effects of factors other than population size. Only two populations (those in the Bonneville and Dalles reservoirs on the Columbia River), both with significant increasing trends, were larger than our MVP estimate. We detected significant decreasing trends in two populations—those be.
Microbial Metal Cycling in Aquatic Environments

This chapter focuses on microbial metal redox metabolism, with an emphasis on iron (Fe) and manganese (Mn) cycling in the water column and surface sediments. It deals exclusively with metal cycling in circumneutral pH environments. The majority of the Fe and Mn that enters aquatic systems comes in the form of insoluble oxides (Fe and Mn) and silicate phases (Fe only; Mn-rich silicates are uncommon), which are produced during weathering of rock-forming silicate minerals (e.g., olivines, pyroxenes, and amphiboles) in the terrestrial environment and transported to coastal marine environments and lakes by rivers and streams. Although insoluble oxide phases are by far the most abundant forms of Fe(III) and Mn(IV) in neutral-pH aquatic environments, several recent studies suggested that small but significant quantities of soluble Fe(III) exist in circumneutral sediment pore fluids. A review by Emerson provides an overview of the history of research on circum-neutral bacterial Fe(II) oxidation as well as the physiology and systematics of Fe(II)-oxidizing bacteria (FeOB). In light of the foregoing analysis of the role of microbes in the oxidative side of the Fe and Mn cycles in aquatic environments, it is clear that Fe and Mn redox cycling is an example of microbial syntrophy analogous to the well-known syntrophic relationships among N- and S-oxidizing and -reducing microorganisms in natural systems. Both the water column and sediment chemical profiles illustrate several key aspects of the Fe-Mn redox cycling systems in aquatic environments.
Unitary exocytotic and endocytotic events in Zea mays L. coleoptile protoplasts

SummaryCell-attached capacitance measurements were used todetect unitary exocytotic and endocytotic events in proto-plasts from Zea mays L. coleoptiles with a high-frequencylock-in ampliﬁer. A background noise level of around 70aF permitted the detection of interacting vesicles with adiameter as small as 60 nm. The distribution of discreteon-steps (exocytosis) was similar to that of off-steps(endocytosis) with a modal values at about 200 aF forboth events. From the frequency of endocytotic events(1.5 K 1.4 min –1 ) it is estimated that 200 min are requiredforthewholemembranetobeingestedinanon-stimulatedprotoplast.Introduction A continuous ﬂow of transport vesicles from the endo-plasmic reticulum (ER) to the cell surface is essential forplant cell growth and development (Battey and Blackbourn,1993). In particular in elongating cells, fusion of vesicleswith the plasma membrane is thought to provide themembrane needed for the increase in cell surface area(Phillips et al . , 1988; Quaite et al
Acclimation to Iron Limitation in the Haptophyte Coccolithus pelagicus: A Molecular Investigation

Phytoplankton growth is iron limited in at least 20% of the world’s oceans. Iron is an important nutrient required to synthesise enzymes necessary for photosynthesis, respiration, and nitrogen assimilation. Due to its low solubility in seawater, iron limitation of phytoplankton production has been the focus of much recent research. These organisms secrete ligands in order to solubilise the available iron, but not all of the iron dissolved in seawater is biologically available. In this study a molecular based approach was employed to investigate the acclimation of the marine haptophyte Coccolithus pelagicus to iron limitation. Using two dimensional electrophoresis, subtractive cDNA hybridisation, and RT real time PCR, changes in the proteome and in gene expression were examined. Iron limited cells were characterised by slower specific growth rates, lower chlorophyll a concentrations per unit biomass and less extensive calcification relative to iron replete cells. Addition of iron to iron limited cultures resulted in increased specific growth rates and increased chlorophyll a concentration per unit biomass. A subtracted cDNA library revealed seventeen identifiable sequences of which photosystem I protein E (PsaE), a fucoxanthin binding protein transcript, two chlorophyll binding proteins and a predicted membrane protein were shown to be upregulated in iron-limited cells to varying extents. Two dimensional SDS PAGE revealed 11 differentially expressed proteins in iron limited cells and 1 highly
Plasticidade trófica em peixes de água doce

A synthesis on the feeding flexibility in freshwater teleosts concerning seasonal, spatial, ontogenetic, individual and behavioral variation of freshwater teleosts is provided. The occurrence of a flexible diet is a striking aspect of tropical riverine ichthyofauna where most species may switch from a food item to another as soon as the relative abundance of the feeding resource in use oscillates, motivated by seasonal and spatial environmental alterations. There is a trophical change in almost all species during ontogeny, whereas in most populations, individuals may show feeding preferences or make use of distinct feeding tactics that lead towards a differentiated intraspecific foraging. These considerations highlight the difficulty on setting up reliable specific species feeding patterns in tropical teleosts
Animal science reviews

1.Protein nutrition and nitrogen balance in buffalo cows 2.Expression QTL and their applications in genetic improvement of farm animals 3.A brief history of mammalian coat colour genetics 4.Functional genomic approaches to understand the biological pathways underpinning intramuscular fat in beef 5.Assessing impacts of organic production on pork and beef quality 6.Whole genome marker-assisted selection 7.Quantitative trait mutations in cattle, sheep and pigs: a review 8.Technical, epidemiological and financial implications of large-scale national vaccination campaigns to control HPAI H5N1 9.Accelerated lambing: Part 1. Housing for sheep 10.Accelerated lambing: Part 2. Increasing the frequency of pregnancy in sheep 11.Poultry sector development, highly pathogenic avian influenza and the smallholder production systems 12.Fat and taste perception 13.Microgoats in India and their role in future animal production in an era of climatic change 14.Assessing biosafety of GM plants containing lectins 15.Ovine and caprine brucellosis (Brucella melitensis) 16.Plants as reservoirs for human enteric pathogens 17.Use of high-density marker genotyping for genetic improvement of livestock by genomic selection 18.Natural antimicrobials for food processing 19.Palatability: principles, methodology and practice for farm animals 20.Embryo cryopreservation in domestic mammalian livestock species 21.Risk assessment of toxic contaminants in animal feed.