Miracle-dz/UniFAR-FTUs huggingface dataset:
REM Sleep Instability – A New Pathway for Insomnia?

Abstract Chronic insomnia afflicts approximately 10% of the adult population and is associated with daytime impairments and an elevated risk for developing somatic and mental disorders. Current pathophysiological models propose a persistent hyperarousal on the cognitive, emotional and physiological levels. However, the marked discrepancy between minor objective alterations in standard parameters of sleep continuity and the profound subjective impairment in patients with insomnia is unresolved. We propose that “instability” of REM sleep contributes to the experience of disrupted and non-restorative sleep and to the explanation of this discrepancy. This concept is based on evidence showing increased micro- and macro-arousals during REM sleep in insomnia patients. As REM sleep represents the most highly aroused brain state during sleep it seems particularly prone to fragmentation in individuals with persistent hyperarousal. The continuity hypothesis of dream production suggests that pre-sleep concerns of patients with insomnia, i. e. , worries about poor sleep and its consequences, dominate their dream content. Enhanced arousal during REM sleep may render these wake-like cognitions more accessible to conscious perception, memory storage and morning recall, resulting in the experience of disrupted and non-restorative sleep. Furthermore, chronic fragmentation of REM sleep might lead to dysfunction in a ventral emotional neural network, including limbic and paralimbic areas that are specifically activated during REM sleep. This dysfunction, along with attenuated functioning in a dorsal executive neural network, including frontal and prefrontal areas, might contribute to emotional and cognitive alterations and an elevated risk of developing depression.
A Parallel Biomedical Data Transportation Component and its Application

In order to increase the biomedical data transportation efficiency of distributed medical databases and meet the demands of real-time process, we propose a parallel biomedical data transportation component to manage the datasets replicas and use four adaptive parallel transportation strategies within a distributed databases environment. This component makes better use of the bandwidth and storage of each server node in which stored the biomedical databases, the application in distributed breast cancer databases with this component shows remarkably higher data transportation efficiency than the comparative experiment without it.
The Recording of Monophasic Action Potentials with Fractal‐Coated Iridium Electrodes in Humans

The present study was designed to evaluate the feasibility of the recording of monopha‐sic action potentials (MAP) with fractal‐coated iridium electrodes in a clinical setting. In 18 patients who underwent an electrophysiological study for various arrhythmias, we performed MAP recordings with both 1,3‐mm2 and 6‐mm2 tip surface area fractal‐coated iridium and standard silver‐silver chloride (Ag/AgCl) electrodes in the high right atrium and two ventricular positions. Amplitude and MAP duration at 90%, 50%, and 25% of repolarization were calculated during steady‐state pacing at 600, 500, and 400 ms cycle lengths with extrastimuli application. Morphology comparisons of MAP signals recorded with both types of electrodes were performed by regression analysis using 5% of the repolarization segments of the MAP trajectory. Differences between MAP duration at 90%, 50%, and 25% of repolarization recorded with fractal‐coated and Ag/AgCl electrodes were statistically insignificant. Amplitude values recorded with 6‐mm2 tip electrodes were significantly smaller than those recorded with Ag/AgCl electrodes for all comparisons. During steady‐state pacing, the correlation coefficients between Ag/AgCl and fractal‐coated 1.3‐mm2 and 6‐mm2 tip electrodes were within the range of 0.93–0.999 and 0.87–0.999, respectively. The correlation of MAP amplitude and duration at 90%, 50%, and 25% of repolarization following the ex‐trastimulus S2, recorded with both types of electrodes, was significantly weaker for right atrial recordings (r value range 0.78–0.92) as compared to ventricular recordings (r value range 0.92–0.99). The MAP sensing features of fractal‐coated iridium and Ag/AgCl electrodes are comparable. The best results for recording of MAPs with fractal‐coated electrodes can be achieved with small surface area tip electrodes.
A Deep Recurrent Network for Web Server Performance Prediction

Recurrent neural network(RNN) has been widely applied to many sequential tagging tasks such as natural language process(NLP), and it has been proved that RNN works well in those areas. In this paper, we propose to use RNN with long short-term memory(LSTM) units for web server performance prediction. Classical methods focus on building relation between performance and time domain, which can't capture the essence of web server performance. In this paper, we analyze the log of nginx web servers which contains user's url access sequence, and predict the performance of the servers by using RNN-LSTM. Experiment result shows that our model gets a good performance in predicting web server performance on the data set which has been deployed in online service.
Nuclear magnetic resonance imaging of tumour growth and neovasculature performance in vivo reveals Grb7 as a novel antiangiogenic target

Development of neovasculature is a necessary requirement for tumour growth and it provides additional opportunities for therapeutic intervention. However, current antiangiogenic therapies have limited efficacy, mostly because of the development of resistance. Hence, characterization of new antiangiogenic molecular targets is of considerable clinical interest. We report that a calmodulin‐binding domain (CaM‐BD) deletion mutant of the growth factor receptor bound protein 7 (Grb7) (denoted Grb7Δ) impairs tumour growth and associated angiogenesis in vivo. We implanted glioma C6 cells in rat brains transfected with an enhanced yellow fluorescent protein (EYFP) chimera of Grb7∆, its EYFP‐Grb7 wild type counterpart, and EYFP alone. We systematically followed intracerebral growth of the tumours, their cellularity and the functional performance of tumour‐associated microvasculature using magnetic resonance imaging, including anatomical T1W and T2W images and functional diffusion and perfusion parameters. Tumours grown from implanted C6 cells expressing EYFP‐Grb7Δ developed slower, became smaller and presented lower apparent cellularity than those derived from cells expressing EYFP‐Grb7 and EYFP. Vascular perfusion measurements within tumours derived from EYFP‐Grb7∆‐expressing cells showed significantly lower cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) values. These findings were independently validated by histological and immunohistochemical techniques. Taken together, these findings confirm that the CaM‐BD of Grb7 plays an important role in tumour growth and associated angiogenesis in vivo, thus identifying this region of the protein as a novel target for antiangiogenic treatment. Copyright © 2013 John Wiley & Sons, Ltd.
Quality Assessment of Perinatal and Infant Postmortem Examinations in Turkey

An autopsy examination is important in identifying the cause of death and as a means of auditing clinical and forensic practice; however, especially in perinatal and infantile age groups determining the cause of death leads to some difficulties in autopsy practice. In this study, 15,640 autopsies recorded during the years 2000–2004 in the Mortuary Department of the Council of Forensic Medicine were reviewed. Autopsy findings of 510 cases between 20 completed weeks of gestation and 1 year of age were analyzed retrospectively. The quality of each necropsy report was assessed using a modification of the system gestational age assessment described by Rushton, which objectively scores aspects identified by the Royal College of Pathologists as being part of a necropsy. According to their ages, the cases were subdivided into three groups. Intrauterine deaths were 31% (158 cases), neonatal deaths were 24% (123 cases), and infantile deaths were 45% (229 cases) of all cases. Scores for the quality of the necropsy report were above the minimum acceptable score with 44% in intrauterine, 88% in neonatal and infantile deaths.
Betriebsratstypen und Personalfluktuation: Eine empirische Untersuchung mit Daten des NIFA-Panels

Theoretische Uberlegungen und bisherige empirische Untersuchungen sprechen dafur, das Betriebsrate einen die Personalfluktuation reduzierenden Einflus ausuben. Dieses Ergebnis wird unter Verwendung des NIFA-Panels fur den Fertigungsbereich deutscher Maschinenbaubetriebe bestatigt. Erstmals werden auch die Effekte einer Neugrundung oder Auflosung des Betriebsrats sowie unterschiedliche Betriebsratstypen berucksichtigt. Insbesondere ein Miteinander von Betriebsrat und Betriebsleitung senkt die Personalfluktuation, was folglich im gemeinsamen und nicht nur im Arbeitnehmerinteressen liegen mus.
EFFICACY OF CHEMICAL ASEPTICIZING SYSTEM FOR SOFT CONTACT LENSES*

ABSTRACT One hundred soft contact lens wearers were monitored for bacterial flora of tears, contamination of lens storage solutions, and pH of tears and lens storage solutions. All wearers used Flexsol as a lens cleaning and storage solution, and Normol as a lens rinsing solution. It was concluded that contamination of a wearer's storage solution occurred only if the wearer failed to follow instructions in the use of solutions in his daily lens care.
Detection of a Salmonella enterica Serovar California Strain Spreading in Spanish Feed Mills and Genetic Characterization with DNA Microarrays

ABSTRACT We performed an epidemiological study on Salmonella isolated from raw plant-based feed in Spanish mills. Overall, 32 different Salmonella serovars were detected. Despite its rare occurrence in humans and animals, Salmonella enterica serovar California was found to be the predominant serovar in Spanish feed mills. Different typing techniques showed that isolates of this serovar were genetically closely related, and comparative genomic hybridization using microarray technology revealed 23 S. enterica serovar Typhimurium LT2 gene clusters that are absent from serovar California.
Enhancing Salt-and-Pepper Noise Removal in Binary Images of Engineering Drawing

Noise removal in engineering drawing is an important operation performed before other image analysis tasks. Many algorithms have been developed to remove salt-and-pepper noise from document images. Cleaning algorithms should remove noise while keeping the real part of the image unchanged. Some algorithms have disadvantages in cleaning operation that leads to removing of weak features such as short thin lines. Others leave the image with hairy noise attached to image objects. In this article a noise removal procedure called TrackAndMayDel (TAMD) is developed to enhance the noise removal of salt-and-pepper noise in binary images of engineering drawings. The procedure could be integrated with third party algorithms' logic to enhance their ability to remove noise by investigating the structure of pixels that are part of weak features. It can be integrated with other algorithms as a post-processing step to remove noise remaining in the image such as hairy noise attached with graphical elements. An algorithm is proposed by incorporating TAMD in a third party algorithm. Real scanned images from GREC'03 contest are used in the experiment. The images are corrupted by salt-and-pepper noise at 10%, 15%, and 20% levels. An objective performance measure that correlates with human vision as well as MSE and PSNR are used in this experiment. Performance evaluation of the introduced algorithm shows better-quality images compared to other algorithms.
Biologia reprodutiva de rubiaceas arbustivas de mata atlantica

A polinizacao e os sistemas de incompatibilidade determinam grande parte do fluxo genico em populacoes de plantas, portanto dados a esse respeito podem contribuir para a compreensao da manutencao da diversidade em diferentes ambientes. A distilia e um mecanismo reprodutivo comumente observado na familia Rubiaceae, sendo caracterizada pela presenca de dois morfos florais reciprocamente hercogâmicos, auto- e intramorfo-incompativeis, e em numero equilibrado na populacao. A ausencia de alguma dessas caracteristicas em grupos comumente distilicos pode evoluir devido a baixa disponibilidade ou comportamento pouco especializado de polinizadores, sendo interpretada como um caso de distilia atipica, ou de uma nova estrategia reprodutiva derivada da distila. O presente estudo investigou a biologia de polinizacao e as relacoes morfometricas e de compatibilidade entre morfos florais de cinco especies de Rubiaceae de Mata Atlântica no sudeste brasileiro: Psychotria jasminoides, Psychotria birotula, P. mapourioides, P. pubigera, P. nuda e Chiococca alba. Foram coletados dados a respeito da biologia floral e de polinizacao, realizados experimentos reprodutivos de todas as especies, alem de medicoes de orgaos florais e estimativas da razao entre morfos das especies distilicas. Apesar de todas as especies possuirem flores tubulares, pequenas, diurnas e de produzirem nectar (exceto C. alba), algumas diferem entre si quanto ao principal grupo de polinizadores. Tres especies sao tipicamente distilicas, duas sao distilicas atipicas e uma possui apenas hercogamia (C. alba). Os resultados indicam perdas da hercogamia reciproca e desvios na razao entre morfos. No entanto, as especies dimorficas apresentaram a sindrome da distilia funcionando conforme o esperado em populacoes estaveis, o que provavelmente e resultado da eficiencia dos polinizadores em transportar polen entre morfos, associada ao sistema de incompatibilidade. Chiococca alba possui uma estrategia diferente das esperadas para sua tribo, mas com caracteristicas de ambas, como a hercogamia, tipica da distilia, e deiscencia das anteras na fase de botao, similar as especies com apresentacao de polen no estilete. Trata-se de uma especie com baixa frequencia de visitas, autoincompativel, com baixa formacao de frutos por autopolinizacao e apomixia, alem de taxa de frutos por polinizacao natural relativamente alta, sugerindo que as poucas visitas associadas aos frutos formados por autopolinizacao e apomixia mantem populacao Abstract
Possible Mechanisms of Local Tissue Renin-Angiotensin System Activation in the Cardiorenal Metabolic Syndrome and Type 2 Diabetes Mellitus

The role of local tissue renin-angiotensin system (tRAS) activation in the cardiorenal metabolic syndrome (CRS) and type 2 diabetes mellitus (T2DM) is not well understood. To this point, we posit that early redox stress-mediated injury to tissues and organs via accumulation of excessive reactive oxygen species (ROS) and associated wound healing responses might serve as a paradigm to better understand how tRAS is involved. There are at least five common categories responsible for generating ROS that may result in a positive feedback ROS-tRAS axis. These mechanisms include metabolic substrate excess, hormonal excess, hypoxia-ischemia/reperfusion, trauma, and inflammation. Because ROS are toxic to proteins, lipids, and nucleic acids they may be the primary instigator, serving as the injury nidus to initiate the wound healing process. Insulin resistance is central to the development of the CRS and T2DM, and there are now thought to be four major organ systems important in their development. In states of overnutrition and tRAS activation, adipose tissue, skeletal muscle (SkM), islet tissues, and liver (the quadrumvirate) are individually and synergistically related to the development of insulin resistance, CRS, and T2DM. The obesity epidemic is thought to be the driving force behind the CRS and T2DM, which results in the impairment of multiple end-organs, including the cardiovascular system, pancreas, kidney, retina, liver, adipose tissue, SkM, and nervous system. A better understanding of the complex mechanisms leading to local tRAS activation and increases in tissue ROS may lead to new therapies emphasizing global risk reduction of ROS resulting in decreased morbidity and mortality.
Pair correlation functions in prostate 362 clusion of nuclear features in the prognostic factor score may aid in stratifying patients into high-risk and low-risk groups for testing adjuvant therapies for prostate

Department of Anatomy, Histology, and Neuroscience, School of Medicine, Autonomous University of Madrid, Madrid, Spain, Department of Anesthesiology, Hospital Ramón y Cajal, Madrid, Spain, Department of Surgery (Urology), Hospital de La Princesa, School of Medicine, Autonomous University of Madrid, Spain and Department of Medical Basic Sciences, School of Medicine, San Pablo University, CEU, Madrid, Spain
Blue WATCH: Un marco metodológico balanceado para el desarrollo de software en pequeñas empresas

RESUMEN La industria mundial del software esta conformada, en su mayoria, por empresas que tienen menos de 25 empleados. El desarrollo de software, en estas empresas, se lleva a cabo bajo diferentes enfoques que van desde lo artesanal (no gestionado e improvisado) hasta lo altamente disciplinado (planificado, controlado y documentado). Agilidad y disciplina representan dos extremos donde se ubican los metodos de desarrollo de software usados en este importante sector de la economia mundial. Un balance entre estas dos corrientes es considerado, hoy en dia, como el enfoque mas apropiado para este tipo de empresas. Este articulo describe un marco de trabajo metodologico balanceado para el desarrollo de software, denominado Blue WATCH, el cual esta dirigido al desarrollo de aplicaciones empresariales de pequena o mediana complejidad y tamano. Este marco de trabajo es apropiado para pequenos grupos de desarrollo de software de 2 – 10 personas y fue concebido, expresamente, para ser utilizado en pequenas y medianas empresas de desarrollo de software. El marco de trabajo puede ser facilmente adaptado a las caracteristicas particulares de cada empresa, proyecto y grupo de trabajo.
Could urban greening mitigate suburban thermal inequity?: the role of residents’ dispositions and household practices

Over the past decade research on urban thermal inequity has grown, with a focus on denser built environments. In this letter we examine thermal inequity associated with climate change impacts and changes to urban form in a comparatively socio-economically disadvantaged Australian suburb. Local urban densification policies designed to counteract sprawl have reduced block sizes, increased height limits, and diminished urban tree canopy cover (UTC). Little attention has been given to the combined effects of lower UTC and increased heat on disadvantaged residents. Such impacts include rising energy expenditure to maintain thermal comfort (i.e. cooling dwellings). We used a survey of residents (n = 230) to determine their perceptions of climate change impacts; household energy costs; household thermal comfort practices; and dispositions towards using green infrastructure to combat heat. Results suggest that while comparatively disadvantaged residents spend more on energy as a proportion of their income, they appear to have reduced capacity to adapt to climate change at the household scale. We found most residents favoured more urban greening and supported tree planting in local parks and streets. Findings have implications for policy responses aimed at achieving urban climate justice.
Estudio de la absorción y translocación del nitrógeno en cítricos en función del aporte estacional del abono nitrogenado mediante el uso de la técnica de dilución isotópica

Una fertilizacion nitrogenada racional debe contemplar no solo el aporte de una dosis ajustada a las necesidades del cultivo, sino que a su vez debe considerar la correcta distribucion de esta durante el periodo de abonado. Sin embargo, no se dispone de suficiente informacion del efecto que la distribucion estacional del fertilizante tiene sobre la absorcion y la movilizacion del N acumulado en los organos de reserva de los citricos. El objetivo del presente trabajo es evaluar en plantas jovenes de citricos el efecto de la distribucion estacional diferencial del abonado nitrogenado sobre la absorcion del N y su reparto en los distintos organos, la movilizacion del N acumulado en los organos viejos de reserva hacia los oganos en desarrollo, asi como su repercusion en la fructificacion. De este modo, se profundizara tanto en el conocimiento de la dinamica del N en el sistema planta-suelo en los citricos, como en los posiles factores implicados en este proceso, con el fin de ampliar las bases sobre las que descansan los criterios del abonado nitrogenado y optimizar asi la aplicacion estacional de los fertilizantes. Para la consecucion de estos objetivos se recurrio al empleo de la tecnica de dilucion isotopica mediante la incorporacion al sistema planta-suelo de un fertilizante marcado con el isotopo estable 15N. Este se aplico desde el inicio de la actividad vegetativa (principios de marzo) hasta el completo desarrollo del fruto (final de octubre) siguiento tres distribuciones estacionales. Se comparo una distribucion simetrica en la que se aplico igual fraccion de la dosis desde el inicio del abonado hasta principio de julio (final de la caida fisiologica) y desde ese momento en adelante, con otras dos en las que el maximo aporte del abono (75% de la dosis) se adelanto con respecto a esta en los meses comprendidos entre marzo y julio, o se retraso el periodo de julio a octubre.