Miracle-dz/UniFAR-FTUs huggingface dataset:
A human virus protein, poliovirus protein 2BC, induces membrane proliferation and blocks the exocytic pathway in the yeast Saccharomyces cerevisiae.

Inducible synthesis of poliovirus protein 2BC in Saccharomyces cerevisiae arrests cell growth in the G2 phase of the cell cycle, while no effects are observed upon expression of poliovirus genes 2B or 2C, either individually or in combination. Expression of 2BC induces a number of morphological modifications in yeast cells, one of the most striking being the proliferation of small membranous vesicles that fill most of the cytoplasm. These vesicles are morphologically similar to the cytopathic vacuoles that proliferate during the infection of human cells by poliovirus. The transport and processing of several yeast proteins, including vacuolar carboxypeptidase Y, aminopeptidase I or yeast alpha‐mating factor, is hampered upon expression of poliovirus 2BC, suggesting that transport of proteins through the Golgi apparatus is impaired by this viral protein. Finally, a number of 2BC variants were generated and the effects of their expression on yeast growth, cellular morphology and protein processing were analyzed. 2BC variants defective in the NTPase activity were still able to interfere with yeast growth and the exocytic system, while deletion of 30 amino acids at the N‐terminus of 2BC impairs its function. These findings lend support to the idea that 2BC, but not 2B or 2C, is the protein responsible for vesicle proliferation in poliovirus‐infected cells. In addition, the activity of a human virus protein in yeast cells opens new avenues to investigate the exact location at which poliovirus 2BC interferes with the vesicular system and to test the action of other animal virus proteins potentially involved in modifying the vesicular system in mammalian cells.
Biologie de la reproduction de Elagatis bipinnulata (Guoy & Gaimard, 1824) capturé dans le golfe de guinée par la flottille artisanale en Côte d’ivoire

Objectif : le but de ce travail est d’etudier la biologie de la reproduction de Elagatis bipinnulata dans l’ocean Atlantique Est, a travers la determination de quelques parametres tels la sex-ratio, taille de premiere maturite sexuelle, fecondite et la periode de reproduction. Methodologie et resultats : cette etude a ete entreprise de septembre 2015 a Aout 2016 sur des individus captures au filet maillant par les pecheurs artisans exercant dans le golfe de guinee. Des prelevements mensuels de poissons ont ete effectues au quai piroguier d’Abobo-doume (port de peche d’Abidjan). Au total 736 specimens ont ete examines avec 479 femelles et 257 mâles dont la longueur a la fourche varie de 40 a 93 cm. La sex-ratio globale montre une predominance des femelles par rapport aux mâles (1,89:1; x 2 = 66.89 ; p=0,03 < 0,05). La taille de premiere maturite sexuelle determinee pour l’espece est de 60,33 cm chez les femelles et de 63,69 cm pour les mâles Les parametres de reproduction etudies revelent que cette espece se reproduit dans le golfe de guinee au cours du premier semestre de l’annee plus precisement dans la grande saison chaude de mars a juin. La fecondite absolue varie de 52279 a 313282 ovocytes avec une moyenne de 167873±72108 ovocytes. Quant a la fecondite relative, elle oscille entre 31791 a 94778 avec une moyenne de 60155±26708 ovocytes. Mots cles : Elagatis bipinnulata , periode de reproduction, fecondite, sex-ratio, Abobo-doume
Seizures with tonic posturing: Semiologic difference between supplementary sensorimotor area (SSMA) origin and extra‐SSMA origin

In seizures with tonic posturing, differentiation of seizures originating in SSMA from seizures originating in cortices other than SSMA and spreading to SSMA has not been previously attempted. Twenty‐two patients were studied with intractable focal epilepsy with tonic limb posturing as the most prominent semiology, who underwent resective surgery and obtained favorable postoperative seizure outcomes. These 22 patients were divided into an SSMA group (N = 12) and an extra‐SSMA group (N = 10), according to the location of resection. Resection area in the extra‐SSMA group was located in the dorsolateral frontal or prefrontal area in four patients, the frontal operculum (insula) in two, the parietal cortex in three, and the temporoparietal cortex in one patient. Video‐recorded seizures were carefully reviewed. Tonic posturing characteristics and the presence or absence of accompanying symptoms were compared between groups. Incidence of preservation of consciousness was significantly higher in the SSMA group (p < 0.001). Patients in the SSMA group demonstrated a propensity for having unilateral or bilateral asymmetrical tonic limb posturing. In contrast, patients in the extra‐SSMA group had a statistically significantly higher incidence of bilateral symmetrical tonic limb posturing (p < 0.05). These findings may be helpful in identifying seizure origin.
Position control of six-phase induction machine using FuzzyPI controller tuned by genetic algorithms

In this paper, a fuzzy PI (FPI) controller is proposed for position control of six-phase induction motor (6PIM). The fuzzy controller is tuned by using the genetic algorithm so that a high performance of the overall system's response can be achieved. The performance and the robustness of the control system are tested for fully loaded and widely load inertia variations. The proposed scheme is compared to the conventional proportional-integral control and validated by simulation and experimental tests of both control techniques.
Analysis and design of serial error correction code with crosstalk avoidance technique

We propose an energy efficient error control code scheme which utilizes the intrinsic property of Hamming code to avoid crosstalk on the computer bus. By using the coding scheme in the noisy deep sub-micron process environment, the proposed scheme can achieve both error prevention and error correction. Meanwhile comparing to the (8,4) Hamming code (8-bit data bus with 4 information bits) with the inter wire capacitive coupling ratio of 30, it can reduce the energy consumption by 42%, and energy delay product by 12.5%. The saving for a 1-bit but is even higher.
A putative “hepitype” in the ATM gene associated with chronic lymphocytic leukemia risk

Chronic lymphocytic leukemia (CLL) cells are characterized by several chromosomal lesions. Some of these aberrations imply chromosome breaks as a result of unrepaired double strand breaks (DSBs) in the DNA. The ATM (ataxia telangiectasia‐mutated) protein is the principal integrator of cellular responses to DSBs. ATM deletion is also an adverse prognostic factor in CLL. Taking this into account, we evaluated if genetic and/or epigenetic variation in the ATM gene may modulate the individual susceptibility to develop CLL. Our case‐control association study was performed in a large Spanish population of 1,503 individuals, including 742 patients with CLL and 761 controls. We identified one haplotype within the ATM gene that confers an increased risk of CLL development (OR = 1.33; 95% CI: 1.10–1.60). Two polymorphisms of this ATM haplotype eliminated one CpG site each in Introns 15 and 61, causing changes in DNA methylation pattern. These data provide the first evidence for the existence of a putative “hepitype” in the ATM gene associated with CLL risk. © 2011 Wiley‐Liss, Inc.
Uplink scheduling in clustered 3G network with mobile relaying

Hybrid wireless networks are characterized by simultaneously using several radio interfaces to boost system performances. A practical and promising architecture to achieve a better uplink throughput in the traditional CDMA cell is to locally aggregate mobile-generated traffic to some cluster heads through WLAN. Such an architecture opens up questions of the desired clustering structures as well as new uplink scheduling strategies. The scheduling of the aggregated traffic at the cluster heads (called relayed mobile terminals later) is investigated in this work. The proposed uplink scheduling algorithm takes the aggregated traffic nature into account. The scheduling goal is to achieve good throughput under the traffic QoS requirements (e.g. BER, bit-error-rates) and limited power budget at the mobile station. The proposed scheduling algorithm consists of two levels: (1) we use a proportional scheduling algorithm to coordinate the transmission among relaying mobile terminals (RMTs), where the main objective is to achieve high spectrum efficiency and reasonable fairness; (2) within RMT, packets from different leave nodes, with different BER requirements are further scheduled via a link-adaptive CDMA (LA-CDMA) transmission scheme. By exploiting the QoS diversity of the queued packets, the LA-CDMA scheduler is able to generate better usage of power budget, which allows some BER-stringent packets to be transmitted at a higher data rate. The performance improvement of the LA-CDMA scheduler is demonstrated by our simulation results. The system goodput is increased by up to 17% for some traffic type. Our simulation also shows the dynamic of expected BERs, the allocation of transmission power and the modulation depth of the LA-CDMA scheduler.
Chronic mesenteric ischemia: imaging and percutaneous treatment.

Chronic mesenteric ischemia (CMI) is rare and is often diagnosed late. Fatal malabsorption-related complications or acute ischemic events occur in the absence of treatment. Diagnosis depends on careful acquisition of a medical history and elimination of other conditions. No sensitive and specific tests are available for functional diagnosis of CMI. If other causes of abdominal pain and weight loss have been confidently ruled out, evidence of visceral artery occlusion at noninvasive imaging (Doppler ultrasonography, computed tomographic angiography, and magnetic resonance angiography) suggests CMI. Until the 1990s, open surgery was considered the treatment of choice; percutaneous transluminal angioplasty (PTA) was reserved for patients for whom surgery carried a high risk. However, open surgery carries a nonnegligible risk of morbidity and mortality. In recent years, PTA with stent placement has been recognized as a minimally invasive means of obtaining good long-term results with an acceptable recurrence rate and consequently has been suggested for primary treatment of CMI. New treatments including administration of fibrinolytic agents before PTA of chronic occlusions, routine revascularization of one or more arteries, and stent placement will probably be validated in the near future. Similarly, new data on selection of the best approach will become available soon.
14.5GHz energy for dermatological applications - initial in-vivo data with histology

This paper presents the first use of Ku band energy at the spot frequency of 14.5GHz for the treatment of a range of dermatological conditions. Initial in-vivo and ex-vivo results are presented, together with histology and data analysis. The outcome from this work indicates that 14.5GHz energy has a strong potential for future use in treating a number of dermatological conditions, where control of depth in the millimeter range, and uniformity over the area of the heating profile, are of paramount importance.
Une fourmi utilisée au Cameroun dans la lutte contre les mirides du cacaoyer : Wasmannia auropuncta Roger

Communication presentee aux journees d'etudes sur les mirides du cacaoyer dans l'Afrique de l'Ouest. Yaounde 16-19 avril 1969. Fourmis artificiellement transportees d'une plantation a l'autre dans des sortes de nasses constitues par un faisceau de folioles de raphia enfermant des epluchures de canne a sucre ou des noix de palme servant d'appâts et qui ont ete laissees au moins trois jours au contact de ces fourmis. 10 j. apres leur depot ces nasses contenaient des larves et des adultes immatures de Wasmannia. Des comptages par "Knock down" ont montre que cette fourmi chassait les mirides et les fourmis Crematogaster, reduisait la plupart des insectes (hemipteres - orthopteres - coleopteres), mais favorisait la presence des psylles et des cochenilles du genre Saissetia
Dynamic queue length thresholds in a shared memory ATM switch

Buffer management schemes are needed to fairly regulate the sharing of memory among different output port queues in a shared memory ATM switch. Of the conventional schemes, static threshold is simple but does not adapt to changing traffic conditions while pushout is efficient and adaptive but difficult to implement. We propose a novel scheme called dynamic threshold which combines the simplicity of static threshold and the adaptability of pushout. The key idea is that the maximum permissible length, for any individual queue at any instant of time, is proportional to the unused buffering in the switch. A queue whose length equals or exceeds the current threshold value may accept no more new cells. The dynamic threshold procedure presented improves the fairness and switch efficiency by guaranteeing access to the buffer space for all output queues. Computer simulation is used to compare the loss performance of the dynamic threshold technique with that of static threshold and pushout. The dynamic threshold scheme is shown to be a good compromise: while nearly as simple as static threshold control, it offers most of the performance benefits of pushout. Like pushout, the dynamic threshold method is adaptive, so it is more robust to uncertainties and changes in traffic conditions than, static threshold control.
UNUSUALLY LOW INCIDENCE OF DEATH FROM MYOCARDIAL INFARCTION. STUDY OF AN ITALIAN AMERICAN COMMUNITY IN PENNSYLVANIA.

An unusually low death rate from myocardial infarction, less than half that of the surrounding communities, was observed in the Italian-American community of Roseto, Pa, during the seven-year period from 1955 to 1961. The low death rate, observed in both sexes, was particularly striking among the males. There were no deaths of either sex under the age of 47 recorded from myocardial infarction during the study. Whether the relative freedom of Rosetans from death from myocardial infarction is related to their way of life or to genetic or ethnic factors remains to be determined. It would seem, however, that in this community, obesity and a generous consumption of calories, fat, and wine were actually associated with a strikingly low death rate from myocardial infarction.
Cross-Sectional Sampling, Bias, Dependence, and Composite Likelihood

A population that can be joined at a known sequence of discrete times is sampled cross-sectionally, and the sojourn times of individuals in the sample are observed. It is well known that cross-sectioning leads to length-bias, but less well known that it may result also in dependence among the observations, which is often ignored. It is therefore important to understand and to account for this dependence when estimating the distribution of sojourn times in the population. In this paper, we study conditions under which observed sojourn times are independent and conditions under which treating observations as independent, using the product of marginals in spite of dependence, results in proper inference. The latter is known as the Composite Likelihood approach. We study parametric and nonparametric inference based on Composite Likelihood, and provide conditions for consistency, and further asymptotic properties, including normal and non-normal distributional limits of estimators. We show that Composite Likelihood leads to good estimators under certain conditions, and illustrate that it may fail without them. The theoretical study is supported by simulations. We apply the proposed methods to two data sets collected by cross-sectional designs: data on hospitalization time after bowel and hernia surgeries, and data on service times at our university.
Frequency Spectra within Word-Length Classes

Abstract Frequency spectra for words of coinciding length are observed. To this end a method of representation of empirical word frequency spectra is proposed. The exponent of the Zipfian power law shows a strong dependency on word length. For short words this exponent assumes values which cannot be accounted for by Mandelbrot's deduction of the Zipfian law. A theoretical model based on a stochastic process is proposed to explain the unusual values of the exponent.
Deltoid Ligament Strain After Correction of Acquired Flatfoot Deformity by Triple Arthrodesis

Deltoid insufficiency represents a difficult surgical challenge. We have witnessed patients who have developed a valgus tibiotalar deformity following a properly positioned triple arthrodesis. To investigate whether the triple arthrodesis itself, by creating a rigid triple joint complex below the ankle, leads to increased strain of the deltoid complex, a flatfoot model was created in 8 fresh-frozen below-knee amputation specimens. Each specimen was loaded in three gait cycle (GC) positions: Heel strike (0% GC), midstance (10% GC), and heel rise (40% GC). The three components of the ground reaction force (GRF) and the tendon forces consistent with those respective positions were applied. To simulate a posterior tibial tendon insufficient state the posterior tibial tendon was not loaded. Strain at the tibiocalcaneal fibers of the superficial deltoid ligament complex was determined at each of the three foot positions. A triple arthrodesis was performed and the deltoid strains were again recorded for each position. A significant increase in the strain of the deltoid ligament was observed for only the heel rise position (p = 0.007) in our cadaver model following triple arthrodesis. The results favor medializing the calcaneus following arthrodesis to protect the deltoid complex.
Sexual dysfunction in schizophrenia: focus on recent evidence

Antipsychotic medications are known to be commonly associated with sexual dysfunction. Sexual dysfunction is estimated to affect 30–80% of patients with schizophrenia and is a major cause of poor quality of life. However, few comparative studies on the sexual dysfunction effects associated with antipsychotic medication have been published and the effects of the newer atypical antipsychotics have been largely unexamined.
Increased circulating concentrations of PDGF-BB and TGF-β1 in canine generalised demodicosis

SUMMARY The purpose of this study was to investigate the changes of circulating concentrations of platelet derived growth factor BB (PDGF-BB) and transforming growth factor beta 1 (TGF-β1) in dogs with generalised demodicosis. Fifteen dogs with generalised demodicosis diagnosed on clinical findings and microscopic examination of the cutaneous scrapings and 10 healthy dogs were included in the study. Circulating concentrations of PDGF-BB and TGF-β1 were measured by commercial specific ELISA assays. Marked and significant increases in plasma PDGF-BB and in serum TGF-b1 concentrations were evidenced in diseased dogs. Circulating PDGFBB concentrations were closely and positively associated with TGF-β1 concentrations in affected dogs (r = 0.92, p < 0.001). These results indicate that the increased concentrations of circulating PDGF-BB and TGF-β1 play a pivotal role in the pathogenesis of the canine demodicosis.
Blood pressure measurement: current practice and future trends.

ophthalmic opticians should be used for such screening. Though some diabetics requiring treatment were detected in their study, the false negative rate is uncertain. Their detection rate was half that of a major screening programme described by Mr Anthony J Bron in the same issue. An attempt was made for an ophthalmologist to recheck some patients screened by the opticians but the very high failure to attend (450(,) made this inadequate. It is possible that diabetics requiring treatment have been overlooked, yet they consider themselves to have been screened. It is uncertain whether they are the responsibility of the ophthalmologist or of the optician. Screening by opticians presently reaches only those who need and can afford spectacles, and recent legislation will further reduce this number. If all diabetics attended regularly, irrespective of the need for spectacles, the opticians would charge the NHS for a sight test and this would be very costly. Opticians were asked to record the appearance of diabetic retinopathy, necessitating a subjective assessment on their part. This is different from the numerical value obtained in screening for glaucoma and is a medical assessment for which they are not qualified and may make them liable to litigation. There is increasing medical unemployment, which will be aggravated by this proposed delegation of medical duties. Those engaged in ophthalmology must train medical practitioners and students to perform ophthalmoscopy and to regard screening of the diabetic fundus through dilated pupils as routine. ROBERT WILLIAMS
The Epidemiology of Leptospira Infection in Mazandaran Province, Northern Iran, During 2012 - 2013

1Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran 2Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, IR Iran 3Department of Microbiology, Islamic Azad University, Nourth Tehran Branch, Tehran, IR Iran 4Department of Microbiology, Guilan Science and Research Branch, Islamic Azad University, Rasht, IR Iran 5Department of Medical Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran 6Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran
Nitinol Self-Expanding Stents vs. Balloon Angioplasty for Very Long Femoropopliteal Lesions

Purpose To compare the patency rates and clinical outcomes of balloon angioplasty vs. nitinol stent placement for patients with short (≤150 mm) as compared to long (>150 mm) femoropopliteal (FP) occlusive lesions. Methods Between 2006 and 2011, 254 patients (134 men; mean age 68 years) underwent FP angioplasty. The majority of patients (64%) were treated for critical limb ischemia. One hundred thirty-nine (55%) patients had short FP lesions ≤150 mm, while 115 patients had long FP lesions >150 mm. The mean lesion length was 78±43 mm in the short FP lesion group and 254±58 mm in the long FP lesion group. Duplex ultrasound follow-up with a peak systolic velocity ratio ≥2.0 was used to define restenosis. Results The overall procedure success rate was 98%. One hundred forty-eight (58%) patients underwent stent placement. The mean number of stents deployed for treatment of short FP lesions was 1.0±0.4 vs. 2.0±0.7 for long FP lesions (p<0.001). The primary patency rate of short FP lesions treated with balloon angioplasty vs. stenting was 66% vs. 63% at 1 year (p=0.7). For long FP lesions, the 1-year primary patency rates of balloon angioplasty vs. stenting were 34% vs. 49% (p=0.006). Balloon angioplasty of long FP lesions was also associated with significantly lower assisted primary and secondary patency compared to stenting (p<0.05 for all comparisons). Sustained clinical improvement was >90% at 30 days but declined to 62% to 75% at 1 year. Conclusion Balloon angioplasty and stent placement result in similar patency rates and clinical outcomes for shorter to medium-length FP lesions. In comparison, stent placement in long FP lesions is associated with superior outcomes to balloon angioplasty, even when multiple stents are required. Procedure success and clinical improvement can be achieved in the majority of patients, but rates of restenosis remain high.