Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Parental Attention on the Academic Achievement of Rural and Urban Secondary School Students of Expatriate Parents

The purpose of the study was to find out the role of parental attention on academic achievement of students of expatriate parents. The study particularly deals with the role of parental attention on academic achievement of rural and urban students separately. The sample for the study was collected from various schools of Malabar region in the state of Kerala. Sample consists of 600 secondary school students whose fathers are working abroad of which 300 are rural students and 300 are urban students. A self made tool was used to measure the parental attention and the score of annual examination was taken as the indicator of academic achievement. Mean standard deviation and t-test was used for analyzing data. Students were classified into three groups based on the parental attention they get; namely high attention group, average attention group and low attention group. A comparison of percentage of achievement was done further. The study revealed that there is a significant relation between the academic achievement and parental attention among the secondary school students of expatriate parents in urban area where as it revealed that there is no significant relation between the academic achievement and parental attention among the secondary school students of expatriate parents in rural area.
Clinical pattern of ascites in a Saudi series

Objectives: To evaluate clinical pattern of ascites. Design: Analysis of data obtained from 228 patients admitted over a period of 7 years, Setting: King Khalid University Hospital, Riyadh. Subjects: Patients admitted with ascites between 1405 and 1411 H (1985-1991 G) who had haematological, biochemical and microbiological examination of ascitic fluid. Results: Liver cirrhosis accounted for 50.4% of cases and malignant liver disease for 14.9% patients with and without liver cirrhosis. Other hepatic causes of ascites were chronic active hepatitis in 6.6% and hepatic schistosomiasis in 3.9% of patients. Other diseases associated with ascites included peritoneal tuberculosis, cardiac failure, renal disease and other causes in 10, 4.8, 4.4 and 4.8% of patients, respectively. Conclusion: Hepatic diseases are the major causes of ascites with cirrhosis as the leading cause
Risk of relapse with imatinib (IM) discontinuation at 5 years in advanced GIST patients: Results of the prospective BFR14 randomized phase III study comparing interruption versus continuation of IM at 5 years of treatment: A French Sarcoma Group Study.

10032 Background: We previously showed in the BFR14 study that IM interruption results in increased risk of disease progression (PD) after 1 and 3 years (yr) in non progressing patients (pts). The impact of IM discontinuation on progression free survival (PFS) in responding pts at 5 yrs is unknown. Methods: This prospective multicenter BFR14 study was initiated in 06/02 and completed inclusion in 05/09. After 1, 3, and 5 yrs of IM 400 mg/day, pts free from PD were randomly offered to continue (C arm) or Stop (S arm) IM. Pts allocated to the S arm had to restart IM (same dose) in case of PD. Primary endpoint was PFS. A Bayesian model was implemented for this part of the BFR14 study. Results: Overall, 434 pts were included in the BFR14 study. Fifty-eight (n=26 vs. n=32), 50 (n=25 vs. n=25) and 21 (n=11 vs. n=10) non progressive pts at were randomized at 1, 3 or 5 yrs in the S vs C arms. The 2 yr-PFS were 13% and 16% in the S arms after 1 and 3 years of treatment compared to 62% and 80% in the C arms after 1.
Redirecting dendritic cells and macrophages towards tumour rejection.

The liver expressed chemokine CCL16/LEC exerts chemotactic activity on human monocytes and lymphocytes and is also active on murine cells. An adenovirus encoding the chemokine CCL16 was used to test whether this chemokine might inhibit pre-existing tumors in mice. AdCCL16, but not control empty vector, when injected in established TSA mammary carcinoma, significantly delayed tumor growth. Immunohistochemistry revealed accumulation at tumor site of CD4+ and CD8+ T cells, macrophages, and dendritic cells (DC) the latter being also enriched in draining lymph nodes. Despite the robust and rapid immune response triggered by intratumoral injection of AdCCL16, the lesions were not completely rejected. However the same treatment given before surgical excision of primary lesions prevented metastatic spread and cured 63% of mice bearing the 4T1 mammary adenocarcinoma. The finding of an hostile tumor microenvironment preventing innate immunity explains the weak effect on the primary tumor. As CCL16 promotes accumulation of macrophages and DC at the site of pre-established tumor nodules this treatment was combined with the TLR9 ligand CpG and with anti-interleukin 10-receptor (IL10R) antibody to contrast the local tumor-induced immunosuppression. CpG plus anti- IL10R promptly switched M2 infiltrating macrophages to Ml that, triggering a strong innate response, debulked large tumors within 16 hrs. Tumor infiltrating DC matured and migrated in parallel with the onset of the innate response, allowing the initiation of adaptive immunity before the diffuse hemorrhagic necrosis halted the communication between tumor and draining lymph node. Treatment of B6>CXB6 chimeras implanted with BALB/c tumors induced an efficient innate response but not CTL-mediated tumor lysis; in these mice tumor rejection did not exceed 25%. The requirement of CD4 help for an effective CTL induction was shown in CD40KO, as well as in mice depleted for CD4 T cells during the priming rather than the effector phase. Together the data describe the critical requirements for the immunological rejection of large tumors: a hemorrhagic necrosis initiated by activated Ml macrophages and a concomitant DC-migration to DLN for subsequent CTL priming and clearing of any tumor remnants.
Scientific Opinion on Fish Oil for Human Consumption. Food Hygiene, including Rancidity

In this document an evaluation of hygiene and rancidity of fish oil intended for human consumption was carried out until the point of the production chain for fish oil at which a product intended for human consumption is obtained as a bulk stored product. This does not include encapsulated or other consumer packages or the final product ready to be sold to the consumer. Within the scope of this document, only oxidation products may represent a potential chemical hazard in refined fish oil intended for human consumption whilst stored in bulk. The refined fish oil production process typically includes several steps such as repeated heating at high temperatures (at 90-95°C and even up to 180°C) as well as alkali/acid treatments and removal of the water phase, which reduce the biological food safety risk to negligible. Lipid oxidation in bulk stored fish oil can be prevented by cold storage in darkness, without exposure to oxygen and addition of antioxidants. Based on the currently available information, no qualitative or quantitative risk assessment of hazards in relation to rancidity of fish oil intended for human consumption can be carried out. The criterion of 60 mg total volatile basic nitrogen (TVB-N)/100 g for whole fish is not based on scientific evidence. Sensory assessment is recommended for the evaluation of the freshness of raw material for fish oil production for human consumption. At present, the methods to determine the peroxide and anisidine values are the most reliable chemical methods for rancidity measurements in bulk fish oils. The present knowledge does not allow setting and recommending of maximum acceptable peroxide and anisidine values for the large variety of refined fish oils
Relevance of time-resolved contrast-enhanced MRA during 3-step-angiography (CE – MRA) of the calf in comparison to DSA in patients with PAOD (peripheral arterial occlusive disease) IIb-IV.

Poster: "ECR 2012 / C-1370 / Relevance of time-resolved contrast-enhanced MRA during 3-step-angiography (CE – MRA) of the calf in comparison to DSA in patients with PAOD (peripheral arterial occlusive disease) IIb-IV. " by: "L. Kahr, B. Pernthaler, L. Ebner, A. Obernosterer, M. Aschauer; Graz/AT"
Bipolar Disorders and Carbamazepine: Pharmacokinetics,Pharmacodynamics, Therapeutic Effects and Indications of Carbamazepine: Review of Articles

Carbamazepine is a mood stabilizer which is approved for use in bipolar disorder with manic and mixed episodes. It is also approved for use for the treatment of trigeminal neuralgia, temporal lobe epilepsy (complex partial seizures) and generalized tonic-clonic seizure. It is metabolized in the liver, primarily by CYP450 3A4 and is an inducer of CYP450 3A4 enzyme. The specific mechanism of action of carbamazepine in stabilizing mood is unknown. It exerts effects by decreasing dopamine turn over, enhancement of brain γ-aminobutyric acid (GABA) levels via multiple actions of synthesis and degradation, and modulation of other neurotransmitters, voltage sensitive Na+ channels, extra hypothalamic neuropeptides, secondary messenger systems, and neuro protection. The most common side effects are nausea, vomiting, constipation, diarrhea, loss of appetite, sedation, dizziness and ataxia. Serious side effects may include skin rashes, decreased bone marrow function and confusion. It should not be used in those with a history of bone marrow problems. Routine blood level monitoring is necessary. There is an increased risk of fetal abnormalities if carbamaepine taken in pregnancy. Carbamaepine concentrations are known to be increased with concurrent use of antidepressants (such as fluexetine, fluovoxamine, nefazodone), omeperazole, efavirnaz, ratinovir, valproate, cemitidine and erythrpmycin. Its level decrease when administrated with Rifampin and Cisplatin.
Current clinical practices, experiences, and perspectives of healthcare practitioners who attend to dysfunctional breathing : a qualitative study

Background The under-recognised and often misdiagnosed condition of dysfunctional breathing (DB) requires urgent critical investigation of the practices, experiences, and perspectives that underlie current clinical practice. Objective To explore current clinical practices, experiences, and perspectives of healthcare practitioners currently attending to DB. Design This qualitative exploratory study employed interpretive description. Referral and snowball sampling recruited six participants. Methods Data collection methods involved semi-structured in-depth interviews with three osteopaths and three physiotherapists. Interviews were deconstructed and analysed, and themes were developed. Results The complex journey to optimal breathing emerged as the over-arching theme in narratives of the participants’ own experiences. Three sub-themes were developed highlighting the complex nature of DB: 1) missed by both patient and practitioner, 2) re-establishing a mindbody connection, and 3) a multifaceted approach is key. Conclusions Findings suggest that there is a general lack of awareness surrounding DB by the general population and possibly by many healthcare practitioners. A lack of identification impacts DYSFUNCTIONAL BREATHING: A QUALITATIVE STUDY 60 patient quality of life and can lead to chronic musculoskeletal adaptations. Establishing a mind-body connection allows patients to establish a level of body awareness that allows a change in their breathing pattern back to an efficient and relaxed state that impacts presenting symptoms. A multifaceted approach to treatment is critical to making maximum changes and optimising clinical outcomes.
A review on haematological profile in menstruating, pre-menopausal and menopausal women

In females, the reproductive age is characterized by the onset of menstruation called menarche and ceases with the onset of menopause. The female reproductive cycles are controlled by various hormones and these hormones are known as female hormonal system. The female sexual cycle is the cycle of natural changes that occurs in the uterus and ovary as an essential part of making sexual reproduction possible. Its timing is governed by endogenous biological cycles. During the first few days of each monthly female sexual cycle, the concentrations of both FSH and LH secreted by the anterior pituitary gland increase slightly to moderately, with the increase in FSH slightly greater than that of LH and preceding it by a few days. These hormones, especially FSH, cause accelerated growth of 6 to 12 primary follicles each month. Menstruation is the principal cause of iron loss in women. The menstrual period is associated to the rupture of blood vessels which irrigate the superficial layer of the endometrium. Platelets constitute the first haemostatic component that mobilizes in order to interrupt the bleeding as vascular injury occurs. During menstruation, tremendous numbers of leukocytes are released along with the necrotic materials and blood. This is probable as a result of some substances released by the endometrial necrosis which causes the outflow of leukocytes during menstruation. The paper reviewed haematological profile menstruating women,premenopause women and menopause
Updates from the Third International Congress on Psoriasis: From Gene to Clinic, The Royal College of Physicians, London, U.K., 21–23 November 2002

The Third International Congress on Psoriasis: From Gene to Clinic, organized by Chris Griffiths (Manchester) and Jonathan Barker (London), took place on 21–23 November 2002 at the Royal College of Physicians in London. The 21⁄2 day meeting was well attended by some 270 delegates from the U.K., continental Europe, the U.S.A. and elsewhere, including world leaders in psoriasis research and respected invited speakers from other fields. Chris and Jonathan deserve congratulations for their initiative. The fact that the vast majority stayed the full course, until 1 p.m. on a Saturday, was testimony to the quality of the meeting and certainly not a result of the unrelenting London rainfall. Those fortunate enough to be classified as ‘speakers’ were treated to a superb dinner on the first evening, courtesy of Gordon Ramsay. To those unfamiliar with the delights of British cuisine, G.R. is a famous retired association footballer, lately become successful purveyor of fine cooked food. The glazed chicken liver pâté and goat’s cheese dressed with truffle oil were particularly memorable canapés that were complemented by a fine champagne. My informer’s recollections of the rest of the meal are unfortunately rather hazy, but I gather that the highest quality was maintained. On the following evening, delegates enjoyed a convivial and equally delicious meal at J.B. ’s regular evening venue, the Royal Automobile Club in Pall Mall. Trainees contemplating an academic career should appreciate that relief from the hard grind is sometimes to be found. To the science and a review of some of the work presented. Aspects of the meeting would have been of interest to the general clinical dermatologist, but it was targeted at and attended mainly by clinicians and basic scientists with a special interest in psoriasis. Time and space prevent me from mentioning all presentations, but I have selected a range of topics that I feel able to review in a reliable manner and which I hope will be of some interest to the general readership of this journal. Both oral and poster communications were provided, the former characterized by the three Ps (Powerpoint, Powerpoint and Powerpoint). Those sceptical about the efficacy of modern digital projection should note that 44 of the 45 oral presentations were given in this manner without flaw. College staff were rightly congratulated on the quality of the projection.
Quelles sont les données épidémiologiques concernant le tabagisme parental et l'allaitement maternel ?

L'allaitement exclusif pendant 6 mois donne une bonne protection contre les infections respiratoires pour la premiere annee de vie du nourrisson. Le tabagisme des parents non seulement cree un exces de risque de maladies respiratoires pour les bebes, mais il joue aussi un role important dans le non allaitement ou le sevrage precoce, privant ainsi le nourrisson des protections possibles par l'allaitement. De ces faits, 3 recommandations principales peuvent etre donnees : promouvoir l'arret de tabac chez la mere mais aussi chez le pere pourrait etre une cle dans l'encouragement pour l'allaitement ; ameliorer les chances d'une mere fumeuse de reussir l'allaitement en la conseillant d'eviter de fumer les deux heures et demie precedant la tetee ; encourager le pere fumeur a aider l'allaitement en evitant d'enfumer la mere autant que le bebe.
Maladie veineuse thrombo-embolique et cancer quels enjeux diagnostiques et thérapeutiques ?

1 © La Lettre du Cardiologue 2009; 421:30-3. * Service de médecine nucléaire et biophysique, CHU de Brest. ** Service de cardiologie, CHU de Brest. *** Département de médecine interne et pneumologie, CHU de Brest. L’association entre maladie veineuse thromboembolique (MVTE) et cancer fut décrite pour la première fois par A. Trousseau en 1865 (1). La petite histoire précise que, un an après sa description de ce syndrome, un épisode de phlébite vint compliquer des douleurs gastriques dont il souffrait. Il déclara alors à son élève : “Je suis perdu, une phlébite qui vient de se déclarer cette nuit ne me laisse plus aucun doute sur la nature de mon mal. ” Le destin lui permettait ainsi tristement de vérifier la justesse de son observation, puisqu’il mourut d’un cancer gastrique quelques mois plus tard. Cette association a, par la suite, fait l’objet de nombreuses études. Cependant, beaucoup de questions restent à ce jour sans réponses, que ce soit au niveau des mécanismes physiopathologiques ou de la prise en charge diagnostique et thérapeutique.
Biological Screening of Eichornia crassipes against Different Pathogenic Microbes: An In Vitro Study

The present research is a biological screening of Eichornia crassipes (Pontederiaceae). Dichloromethane and methanol extracts of the whole plant were investigated for their antibacterial, antifungal, phytotoxic, and cytotoxic activities. The antibacterial activity was evaluated using agar well-diffusion method against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, and Salmonella typhi. The antifungal activity was evaluated using the agar tube–dilution method against Candida albicans, Candida glabrata, Aspergillus flavus, Microsporum canis, and Fusarium solani. The phytotoxicity activity was determined using Lemna bioassay against Lemna minor. Brine shrimp–cytotoxicity assay was determined against brine-shrimp larvae. Dichloromethane extract exhibited significant phytotoxicity (100% growth regulation) at 1,000 μg/ml concentration against Lemna minor whereas methanolic extracts showed moderate (75% growth regulation) phytotoxicity at the same concentration. Methanolic extract showed cytotoxicity at the highest level of dose whereas dichloromethane extract showed no activity having Etoposide as standard drug. Both of the extracts have nonsignificant antifungal and antibacterial activity.
Evaluate the Sustainability of Viral Response to Antiviral Treatment by IL33 Assessment among Hepatitis C virus Saudi Patients

In Saudi Arabia, as a result of using blood donation screening tests, the prevalence of CHC has decreased over the last decade. Moreover, the use of polymerase chain reaction (PCR) techniques as a screening tool for blood donors is likely to enhance the decrease in the rate of HCV transmission. Our biomarkers studied included liver function tests compare the HCV viral loads in the serum and six studied interleukins; IL6, IL9, IL10, IL22, IL33 and IFN-γ cytokines in the patient's group.Also, the study included a comparison between the liver function tests with cytokines levels in 57 patients CHC and 31 healthy control (HC). Interleukins showed different response toward CHC infection according to their percentage change concentration in pg/ml of plasma samples. These are as following: IL10 (33.9%), IL33 (30.0%0), IL6 (26.6%), IL9 (25.7%), IL22 (17.0%) and IFN-ɤ (2.4%). IL-33 had a decrease in its level up to 69.72 pg/ml in CHC group after treatment compared to that of HC group with 99.62 pg/ml. IL-33 was thus proposed to function as a novel alarmin (intracellular alarm signal released upon cell injury) to alert the immune system of tissue damage following trauma or infection. Moreover, levels of IL-33 serum correlated with the concentrations of ALT and AST in CHC patients. Plasma ALT and AST level were significantly higher in the CHC patient group than in the control group (54.8±48.1 IU/L vs. 33.4± 27.1 IU/L, p<0.009 and 50.3±45.5 IU/L vs. 27.5± 21.7 IU/L, p<0.002). IL6, IL9, and IL22 levels were found to correlated with treatment resistance to PEG-IFN/RBV therapy. Moreover, viral load had no correlation with patient's gender and age as well as with liver function tests (AST: 0.595, ALT: 0.882, ALP 0.232, DB: 0.362, GGT: 0.326, ALB: 0.829, TB: 0.469). In conclusion, the current study suggests that IL33 can use as an indicator for detecting the response of patients with CHC to combinational treatment to support the results of liver function tests and viral load and to detect the response of patients to therapy and the progression of the disease.