Miracle-dz/UniFAR-FTUs huggingface dataset:
Forensic Analysis of Colorized Grayscale Images Using Local Binary Pattern

Versatile existence of the digital images creates the need of its forensic analysis. Basically, the goal of forensic analysis is to find the malicious manipulations in the images. However, it can be divided into many categories like splicing and copy move. Sometimes various operations like contrast enhancement, histogram equalization, resampling, etc. need to be detected in forensic analysis. Also there is need of forensic analysis to distinguish between computer generated images and natural images. Now a day’s various techniques are available to colorize the grayscale images. The purpose of these techniques is to color the historic grayscale images. However, to decide the credibility of images it is necessary to differentiate between natural color and colorized images. In this paper, we have applied Local Binary Pattern feature extractor method on colorized images and natural images. We have found good results on two techniques of image colorization.
Age-Gender Analysis of Coronary Artery Calcium (CAC) Score to predict early Cardiovascular Diseases

The paper analyzes the Coronary Artery Calcium (CAC) score metric with respect to the age and gender of the individual. CAC score fairly predicts the risk of cardiovascular diseases. As there is an upsurge in the number of heart patients every day, cardiac health of a person should never be neglected. The Calcium Score involves a non-invasive CT scan of the heart and keeps track of the amount of calcified plaque in coronary arteries. The paper presents statistical comparisons among the scores obtained for males and females across different age groups. These findings are beneficial to predict early Cardiovascular Diseases and surely be useful as an awareness to maintain a healthy lifestyle.
CNNLoc: Deep-Learning Based Indoor Localization with WiFi Fingerprinting

With the ubiquitous deployment of wireless systems and pervasive availability of smart devices, indoor localization is empowering numerous location-based services. With the established radio maps, WiFi fingerprinting has become one of the most practical approaches to localize mobile users. However, most fingerprint-based localization algorithms are computationintensive, with heavy dependence on both offline training phase and online localization phase. In this paper, we propose CNNLoc, a Convolutional Neural Network (CNN) based indoor localization system with WiFi fingerprints for multi-building and multifloor localization. Specifically, we devise a novel classification model by combining a Stacked Auto-Encoder (SAE) with a onedimensional CNN. The SAE is utilized to precisely extract key features from sparse Received Signal Strength (RSS) data while the CNN is trained to effectively achieve high success rates in the positioning phase. We evaluate the proposed system on the UJIIndoorLoc dataset and Tampere dataset with several stateof-the-art methods. The results show CNNLoc outperforms the existing solutions with 100% and 95% success rates on buildinglevel localization and floor-level localization, respectively.
Functional Blockade of Platelet-Derived Growth Factor Receptor-β but Not of Receptor-α Prevents Vascular Smooth Muscle Cell Accumulation in Fibrous Cap Lesions in Apolipoprotein E–Deficient Mice

Background—The vascular smooth muscle cell (VSMC) is the central cell component involved in the fibroproliferative response in atherogenesis. As the lesion advances, VSMCs migrate from the media into the subendothelial space, thereby forming fibrous plaque lesions. Platelet-derived growth factor (PDGF) has been known to be a potent chemoattractant and mitogen for SMCs, but the pathophysiological role of the 2 PDGF receptors, receptor-α (PDGFR-α) and receptor-β (PDGFR-β) in atherogenesis is poorly understood. To clarify this problem, we prepared antagonistic rat monoclonal antibodies, APA5 and APB5, against murine PDGFR-α and PDGFR-β, respectively. Methods and Results—Apolipoprotein E–deficient mice were fed a high-fat diet containing 0.3% cholesterol from 6 weeks of age and subjected to injection with 1 mg/d IP of either antibody from 12 to 18 weeks every other day. In the mice injected with APB5, the aortic atherosclerotic lesion size and the number of intimal VSMCs were reduced by 67% and 80%, respectiv.
The shape of dendritic tips

The present article is focused on the shapes of dendritic tips occurring in undercooled binary systems in the absence of convection. A circular/globular shape appears in limiting cases of small and large Péclet numbers. A parabolic/paraboloidal shape describes the tip regions of dendrites whereas a fractional power law defines a shape behind their tips in the case of low/moderate Péclet number. The parabolic/paraboloidal and fractional power law shapes are sewed together in the present work to describe the dendritic shape in a broader region adjacent to the dendritic tip. Such a generalized law is in good agreement with the parabolic/paraboloidal and fractional power laws of dendritic shapes. A special case of the angled dendrite is considered and analysed in addition. The obtained results are compared with previous experimental data and the results of numerical simulations on dendritic growth. This article is part of the theme issue ‘Patterns in soft and biological matters’.
From nucleation and coarsening to coalescence in metastable liquids

The transition of a metastable liquid (supersaturated solution or supercooled melt) occurring from the intermediate stage (where the crystals nucleate and grow) to the concluding stage (where the larger particles evolve at the expense of the dissolution of smaller particles) is theoretically described, with allowance for various mass transfer mechanisms (reaction on the interface surface, volume diffusion, grain-boundary diffusion, diffusion along the dislocations) arising at the stage of Ostwald ripening (coalescence). The initial distribution function (its ‘tail’) for the concluding stage (forming as a result of the evolution of a particulate assemblage during the intermediate stage) is taken into account to determine the particle-size distribution function at the stage of Ostwald ripening. This modified distribution function essentially differs from the universal Lifshitz–Slyozov (LS) solutions for several mass transfer mechanisms. Namely, its maximum lies below and is shifted to the left in comparison with the LS asymptotic distribution function. In addition, the right branch of the particle-size distribution lies above and is shifted to the right of the LS blocking point. It is shown that the initial ‘tail’ of the particle-size distribution function completely determines its behaviour at the concluding stage of Ostwald ripening. The present theory agrees well with experimental data. This article is part of the theme issue ‘Patterns in soft and biological matters’.
DICE

This paper investigates compression for DRAM caches. As the capacity of DRAM cache is typically large, prior techniques on cache compression, which solely focus on improving cache capacity, provide only a marginal benefit. We show that more performance benefit can be obtained if the compression of the DRAM cache is tailored to provide higher bandwidth. If a DRAM cache can provide two compressed lines in a single access, and both lines are useful, the effective bandwidth of the DRAM cache would double. Unfortunately, it is not straight-forward to compress DRAM caches for bandwidth. The typically used Traditional Set Indexing (TSI) maps consecutive lines to consecutive sets, so the multiple compressed lines obtained from the set are from spatially distant locations and unlikely to be used within a short period of each other. We can change the indexing of the cache to place consecutive lines in the same set to improve bandwidth; however, when the data is incompressible, such spatial indexing reduces effective capacity and causes significant slowdown. Ideally, we would like to have spatial indexing when the data is compressible and TSI otherwise. To this end, we propose Dynamic-Indexing Cache comprEssion (DICE), a dynamic design that can adapt between spatial indexing and TSI, depending on the compressibility of the data. We also propose low-cost Cache Index Predictors (CIP) that can accurately predict the cache indexing scheme on access in order to avoid probing both indices for retrieving a given cache line. Our studies with a 1GB DRAM cache, on a wide range of workloads (including SPEC and Graph), show that DICE improves performance by 19.0% and reduces energy-delay-product by 36% on average. DICE is within 3% of a design that has double the capacity and double the bandwidth. DICE incurs a storage overhead of less than 1KB and does not rely on any OS support.
ВЛИЯНИЕ ПОЧЕЧНОЙ ДИСФУНКЦИИ НА СЕРДЕЧНО-СОСУДИСТУЮ СИСТЕМУ. ВОЗМОЖНОСТИ РАННЕЙ ДИАГНОСТИКИ ПОЧЕЧНОЙ ДИСФУНКЦИИ

The review is devoted to the discussion of modern concepts of the role of renal dysfunction in the development of chronic myocardial dysfunction in the context of cardio-renal syndrome (RVC) type 4. At the beginning of the review, the definition of cattle is given, general questions of pathogenesis and diagnosis of the disease are addressed. It is indicated that in patients with the initial stage of CKD, cardiovascular disorders are already registered which in the late stages of development of renal dysfunction are the leading causes of death and the true severity of the disease in patients with renal dysfunction is associated with an increased risk of cardiovascular events, rather than an achievement terminal renal failure and requiring renal replacement therapy. The progression of renal pathology leads to damage to the heart through various mechanisms and factors, both traditional and non-traditional, some of which, at the culmination of the renal continuum, are the result of the dialysis procedure itself in patients with terminal renal dysfunction. Mechanisms for the development of congestive heart failure in type 4 cattle include pressure overload (arterial hypertension) and volume (anemia, edematous syndrome), which increase in proportion to the decrease in renal function. Increase in blood pressure, changes in intracardial hemodynamics, deterioration of arterial compliance contribute to the acceleration of cardiovascular events. The role of laboratory predictors of renal dysfunction in the progression of cardiovascular disorders is discussed. The general approaches of echocardiographic visualization of the heart cavities and its importance in the diagnosis of cardiovascular diseases are discussed. Special attention is paid to the development of pulmonary arterial hypertension, changes in the left and right ventricle of the myocardium with renal dysfunction.
Exploring HTTP Header Manipulation In-The-Wild

Headers are a critical part of HTTP, and it has been shown that they are increasingly subject to middlebox manipulation. Although this is well known, little is understood about the general regional and network trends that underpin these manipulations. In this paper, we collect data on thousands of networks to understand how they intercept HTTP headers in-the-wild. Our analysis reveals that 25% of measured ASes modify HTTP headers. Beyond this, we witness distinct trends among different regions and AS types; e.g., we observe high numbers of cache headers in poorly connected regions. Finally, we perform an in-depth analysis of the types of manipulations and how they differ across regions.
Prevalence of hearing loss due to ossicular chain involvement in rheumatoid arthritis

Background: Rheumatoid Arthritis (RA) is a chronic multisystem disease commonly affecting the synovial joints. Involvement of middle ear ossicular chain in RA may lead to hearing loss. The effects of hearing loss are profound, with consequences in the social, functional, and psychological well-being of the persons affected. Both conductive and sensorineural types of hearing impairments have been found in these patients in various studies. This study aimed at evaluating the prevalence of hearing impairment in our patients. Methods: Pure tone and impedance audiograms were taken for 100 RA patients who came to the outpatient department. They were divided into three groups based on their disease activity (DAS28). The hearing thresholds were compared among these groups. Tympanographic features and acoustic reflexes were recorded. Disease duration was also taken into account for asessing the severity of hearing impairment. Results: Out of 100 patients, 52 patients had significant hearing impairment audiometrically, of which 44 had sensorineural, 1 conductive and 7 mixed impairments. No significant difference was found between the hearing thresholds and the disease activity but those with high disease activity had higher incidence of abnormal tympanograms (72.2%) and absence of acoustic reflex (55.5%). Prevalence of hearing impairment was found to be increased with increasing disease duration, with steep rise between 5 and 10 years of disease duration. Conclusions: Hearing impairment affects the quality of life adversely. Severity of hearing impairment is significantly associated with having a hearing-related handicap and with self-reported communication difficulties. Thus, hearing assessment if done routinely can improve the outcome in these patients.
Hypotensive effect of resistance training performed on stable vs. unstable surfaces

Senna G, Oliveira CQ, Kreuger S, Scudese E, Monteiro W. Hypotensive Effect of Resistance Training Performed on Stable vs. Unstable Surfaces. JEPonline 2016;19(1):17-26. The purpose of this study was to compare the systolic blood pressure (SBP) and diastolic blood pressure (DBP) responses during two different strength training (ST) surfaces: stable (SST) and unstable (UST). Fifteen trained normotensive women performed 4 nonconsecutive 10RM load test sessions (test and retest for both surface methods) for a whole-body workout. After the load tests, subjects performed two training sessions (SST and UST) with 3 sets of each exercise with loads of 85% of 10RM with a 2-min rest between sets and exercises. The ANOVA two-way showed the same pattern of magnitude reduction on SBP after both training sessions (SST and UST). However, a prolonged reduction of SBP was evident from the SST method (~60 min). For DBP, there were no significant differences between workouts. Thus, although a ST session might trigger a general post-exercise hypotensive effect regardless of the surface method applied (SST and UST), it seems that this effect is more durable after sessions performed with the traditional SST.
GENETIC EVOLUTION AND PROGNOSTIC DETERMINANTS OF PANCREATIC CANCER ON LONGITUDINAL LIQUID BIOPSIES

58 Introduction . 59 Study Design . 61 Results . 62 Characteristics of patients undergoing liquid biopsies . 62 Serial liquid biopsies in localized PDAC patients receiving neoadjuvant therapy are predictive of eventual surgical resection . 66 Clinical correlates of liquid biopsies at presentation in metastatic PDAC patients. 69 Prognostic impact of liquid biopsy parameters at presentation in metastatic PDAC patients . 74 Longitudinal monitoring of metastatic PDAC using serial liquid biopsies anticipates ontreatment progression . 78 Discussion . 81 Chapter 5 – Whole genome, exome, and transcriptome profiling of liquid biopsies with exoDNA . 87 Abstract . 88 Patients and samples. 90 Introduction . 91 Results . 93 Plasma and pleural effusion exosome isolations are enriched with high molecular weight double-stranded genomic DNA . 93 Exosomes contain a large fraction of tumor DNA . 93 ExoDNA is representative of the entire human genome . 97 Comprehensive profiling of tumors using exoDNA and mRNA . 97. 88 Patients and samples. 90 Introduction . 91 Results . 93 Plasma and pleural effusion exosome isolations are enriched with high molecular weight double-stranded genomic DNA . 93 Exosomes contain a large fraction of tumor DNA . 93 ExoDNA is representative of the entire human genome . 97 Comprehensive profiling of tumors using exoDNA and mRNA . 97 ix Discussion . 108 Chapter 6 Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients . 111 Abstract . 112 Introduction . 114 Results . 115 “Surfaceome” profiling of exosomes . 115 Biomarker validation . 117 Validation of capture assay in clinical samples . 118 Enriched cancer-specific exosomal cargo is amenable to comprehensive molecular profiling by NGS . 124 . 126 Discussion . 127 Chapter 7 – Discussion and Future Directions . 131. 112 Introduction . 114 Results . 115 “Surfaceome” profiling of exosomes . 115 Biomarker validation . 117 Validation of capture assay in clinical samples . 118 Enriched cancer-specific exosomal cargo is amenable to comprehensive molecular profiling by NGS . 124 . 126 Discussion . 127 Chapter 7 – Discussion and Future Directions . 131 Bibliography . 138 VITA . 176
Extra Articular Manifestations in Egyptian Rheumatoid Arthritis Patients

Background: Rheumatoid arthritis is a systemic inflammatory disease that can involve other tissues and organs as well as synovial joints. It is characterized by destructive polyarthritis and extra-articular organ involvement, including skin, eye, heart, lung, renal, central and peripheral nervous system and gastrointestinal tract. The extra-articular manifestations of RA can occur at any age. Objectives of this study are to evaluate extra articular manifestations in Egyptian rheumatoid arthritis patients, its relation to the disease activity score (DAS28) and Anti-Cyclic Citrullinated Peptide (ACPA). Methods: This study was conducted on 50 patients they were diagnosed as RA by fulfilling the American College of Rheumatology (ACR) criteria of RA. Their age (mean±SD) is 45.78±13.26 years. Forty four (88%) of them were females, 6 (12%) were males. They were subjected to full medical history and examination, laboratory investigations were done, calculation of DAS28 score, measurement of plasma Anti-Cyclic Citrullinated Peptide (ACPA). RA patients were classified according to DAS 28 into three groups. Results: RA group 1 (mild disease activity) includes 12 (24%) patients with mean±SD of DAS 28 was 2.5±0.55, group II (moderate disease activity) includes 28 (56%) patients with mean±SD of DAS 28 was 3.9±0.55 and group III (severe disease activity) includes 10 (20%) patients with mean±SD of DAS 28 was 5.35±0.238. There was highly significant increase in mean±SD of ACPA titer in group III (sever activity), 90.31±40.78 IU/ml than that of group II 56.48±27.62 IU/ml, (p=0.000) and group1; 36.74±18.95 IU /ml also mean ACPA in group II increased significantly than that of group I, (P=0.000). Fifty (100%) RA patients had extra articular manifestations (ExRA); 37 (74%) had respiratory system disorders, 35 (70%) had hematological manifestations. CVS manifestations were found in 23 (46%). Eye manifestations present in 23 (46%) RA patients. Twelve (24%) RA patients had skin manifestations. GIT manifestations occur in 11 (22%) patients, 5 (10%) RA patients had renal manifestations. Four (8%) RA patients had neurological manifestations. The most common ExRA respiratory disorders was found in 8/12 (66.6%) patients in group I while it affect 22/28 (78.5%) patients in group II and 7/10 (70%) patients in group III (P = 0.000) with highly significant changes. Conclusion: This study showed that the ExRA are a common feature in Egyptian RA patients and they are related to the disease activity. [Egypt J Rheumatology & Clinical Immunology, 2014; 2(1): 71-79]
Comparative Analysis of the Effects of Vasoperssin and Norepinephrine on the Renal Function in Patients Undergoing CABG; A Randomized Clinical Trial

Background: Coronary artery bypass grafting (CABG) is one the most common heart operations, in which blood vessels from other parts of the body, like the saphenous vein, are grafted to the blocked arteries. Due to the widespread use of vasoactive drugs in the course of surgery, and renal complications of these drugs, we aimed to determine the effect of norepinephrine on the renal function of patients with CABG, visiting the cardiac surgery ward of a university affiliated hospital in Ardabil, Iran, with the purpose of maintaining renal perfusion and preventing renal dysfunction in patients undergoing CABG. Objectives: This research aimed to determine and compare the effects of vasopressin and norepinephrine on the renal function of patients undergoing CABG. Methods: This study was a randomized clinical trial. A total of 120 candidates for CABG in a governmental hospital, Iran, during years 2016 2017, were randomly assigned into two groups. The patients’ conditions across the two groups were compared regarding hemodynamics during surgery and post-surgical complications, e.g., renal function (Bun, Cr, and CLCr), using a researcher made questionnaire. Results: The results of our study showed that according to repeated measures test, there was no statistically significant difference during the intervention (P value > 0.05). However, the Independent t-test revealed a statistically significant difference between groups following CABG, which related to the clearance creatinine level. It indicated higher clearance creatinine level in the norepinephrine group (72.83± 25.03 and 78.16± 27.31) than the vasopressin group (64.33± 17.47 and 86.33± 30.54) (P < 0.05), however, the groups did not vary significantly from each other in other items. Conclusions: According to the results of the study, it could be stated that probable renal complications during operation can be reduced to some extent in patients undergoing CABG using inotrope and vasopressor drugs such as norepinephrine.
The effect of thyme honey on anemia in hemodialysis patients

Background & Aim: Anemia is one of the most common complications of chronic renal failure, which is associated with increased fatigue, dyspnea, depression, malaise, prolonged hospitalization and mortality. Some patients are resistant to erythropoietin therapy. Therefore, the purpose of this study was to determine the effect of thyme honey on anemia in hemodialysis patients. Methods & Materials: The present clinical trial was conducted in 2018 at Kowsar Hospital of Semnan on hemodialysis patients randomly selected with convenience sampling method within two groups of case (n=28) and control (n=27). The case group received thyme honey (33 g) daily for one month. The control group did not consume thyme honey. Blood samples were taken from the patients before and after the intervention with 10-hour fasting and then blood parameters were assessed. Results: The mean ±SD reduction rate in hemoglobin level was 0.46±0.96 in the case group and 0.23±3.15 g/dl in the control group, but no significant difference using independent t-test (P=0.758). The mean±SD reduction rate in hematocrit percentages was 1.20±2.78 in the case group and 0.11±8.53 in the control group, but there is no significant difference between the two groups using independent t-test (P=0.590). Conclusion: Results showed that daily administration of 33 grams of thyme honey had no effect on anemia in hemodialysis patients. Further studies are recommended with modification of the methodology regarding the type, dose, duration and instructions of honey consumption for better results.