Miracle-dz/UniFAR-FTUs huggingface dataset:
Extreme Appraisals of Internal States and Duration of Remission in Remitted Bipolar Patients.

INTRODUCTION To identify dysfunctional attitudes seen in bipolar disorder (BPD) is important for the cognitive theories of BPD and corresponding psychosocial interventions. Cognitions are seen as vulnerability factors in the development and maintenance of BPD. The present study aims to contribute to the cognitive literature on BPD by examining depressive and hypomanic attitudes and their contribution to the prediction of BPD diagnosis as well as by exploring the relationship between dysfunctional cognitions and clinical features (types of episodes experienced, duration of illness, and duration of remission). METHODS One hundred and eighteen remitted bipolar patients and 103 healthy controls completed the Mood Disorder Questionnaire (MDQ), Turkish Brief-Hypomanic Interpretations and Positive Predictions Inventory (HAPPI), and Dysfunctional Attitudes Scale. RESULTS The bipolar group had significantly higher depressive and hypomanic attitudes than the control group. No significant differences were found regarding the types of episodes experienced and duration of illness. However, both types of attitudes decreased as the duration of remission increased. They were also found to contribute to the prediction of bipolar diagnosis together with the screening of the MDQ. CONCLUSION The results pointed out that dysfunctional cognitions may be utilized as possible indicators for the risk of relapse in clinical groups and vulnerability for BPD among other populations.
Açık kaynak yazılımlarda bakım yapılabilirliği ve güvenilirliği ölçmek için iki boyutlu değerlendirme metodu

Son yillarda acik kaynak yazilimlarin (AKY) populerliginin artmasi, birbirine alternatif olarak pazara sunulan bu tur yazilimlarin sayisinin hizla artmasina sebep olmustur. Ancak acik kaynak yazilimlarinin kalitesinin potansiyel kullanicilar tarafindan nasil degerlendirilebilecegine isik tutan akademik calismalar sinirli sayidadir. Dolayisiyla alternatifler arasindan ihtiyac sahiplerinin kalite gereksinimlerini en iyi karsilayanin secilmesi problemi arastirilmasi gereken cazip bir problem haline gelmistir. Bu tez calismasinda literaturde mevcut calismalar sentezlenerek kendi katkilarimizla beraber acik kaynak yazilimlarda bakim yapilabilirligi ve guvenilirligi olcen bir metot gelistirilmistir. Bu olcum icin acik kaynak yazilimlar hem kod-tabanli hem de toplum-tabanli olarak iki boyutlu bir metotla degerlendirilmektedir. Kod-tabanli olcum yapabilmek icin, en guncel kalite modeli olan ISO/IEC 25010’nun secilen icsel oznitelikleri ve bu icsel oznitelikleri olcmek icin nesneye yonelik C&K metrikleri kullanilmistir. Toplum-tabanli olcum yapabilmek icin ise sistem ve yazilim muhendisligi icin olcum sureci standardi olan ISO/IEC 15939 rehber alinarak bilgi ihtiyaclari belirlenmis ve bu bilgi ihtiyaclarini degerlendirmek icin urunlerin veri tabanlarinda depolanan elektronik posta listeleri, problem (hata) raporlari, sikca sorulan sorular vb. tarihsel verilerden turetilen metrikler kullanilmistir. Bu tez calismasinda onerilen iki-boyutlu bu metot, Java dilinde yazilmis uc Java programi insa aracinin (Ing. Java built tool) seciminde kullanilmis ve elde edilen sonuclar tartisilmistir.
Effects of dosing regimen on accumulation, retention and prophylactic efficacy of liposomal amphotericin B.

OBJECTIVES We hypothesized that effective prophylactic treatment of fungal infections would require adequate drug penetration and retention at potential infection sites. Using a mouse model, we examined liposomal amphotericin B (L-AmB) biodistribution, cell localization and retention in kidneys, lungs, liver and spleen to evaluate effective dosing regimens for prophylaxis of Candida glabrata and Candida albicans infections. METHODS Following treatment of mice with cumulative doses of L-AmB (60-225 mg/kg), a bioassay was done to determine tissue drug concentrations 12 h to 6 weeks post-treatment. Immunohistochemical staining with anti-amphotericin B antibodies was used for cellular drug localization. Mice were treated prophylactically with 15-90 mg/kg L-AmB and challenged intravenously 1-7 days later with C. glabrata or they were given a total of 60 mg/kg as daily or intermittent dosing followed by intravenous challenge with C. albicans 3 or 6 weeks later. RESULTS On the basis of microg/g tissue, the relative amount of drug was in the order spleen > liver > kidneys > lungs. Amphotericin B levels were maintained above the MIC for many fungi for 1 week in lungs and for as long as 6 weeks in kidneys and spleen. Drug localized in kidney tubular epithelial cells and in macrophages of liver and spleen. In prophylactic models, fungal burden was reduced by several 1000-fold or was undetectable within target tissues (kidneys, spleen). CONCLUSIONS These observations underscore the importance of including drug tissue levels to obtain a better understanding of L-AmB efficacy. The sustained concentrations of bioactive AmB in many tissues provide a further rationale for investigating L-AmB prophylactic regimens.
Bacillus thuringiensis Bioinsecticides Induce Developmental Defects in Non-Target Drosophila melanogaster Larvae

Bioinsecticides made from the bacterium Bacillus thuringiensis (Bt) are the best-selling bioinsecticide worldwide. Among Bt bioinsecticides, those based on the strain Bt var. kurstaki (Btk) are widely used in farming to specifically control pest lepidopteran larvae. Although there is much evidence of the lack of acute lethality of Btk products for non-target animals, only scarce data are available on their potential non-lethal developmental adverse effects. Using doses that could be reached in the field upon sprayings, we have shown that Btk products impair growth and developmental time of the non-target dipteran Drosophila melanogaster. These effects are mediated by the synergy between Btk bacteria and Btk insecticidal toxins, which induces a significant apoptosis of larval enterocytes, resulting in a decreased intestinal capacity to digest proteins. The harmful effects can be mitigated by a protein-rich diet or by adding the probiotic bacterium Lactobacillus plantarum into the food. Finally, we showed that the larval midgut maintain its integrity upon Btk aggression thanks to both the flattening of surviving enterocytes and the generation of new immature cells arising from the adult midgut precursor cells.
Another possible way to determine the neutrino mass hierarchy

We show that by combining high precision measurements of the atmospheric $\ensuremath{\delta}{m}^{2}$ in both the electron and muon neutrino (or antineutrino) disappearance channels one can determine the neutrino mass hierarchy. The required precision is a very challenging fraction of one per cent for both measurements. At even higher precision, sensitivity to the cosine of the $CP$ violating phase is also possible. This method for determining the mass hierarchy of the neutrino sector does not depend on matter effects.
Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost‐effective and age‐independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients

In first‐degree relatives of type 1 diabetic patients, we investigated whether diabetes risk assessment solely based on insulinoma antigen 2 (IA‐2) and zinc transporter 8 (ZnT8) antibody status (IA‐2A, respectively, ZnT8A) is as effective as screening for three or four autoantibodies [antibodies against insulin (IAA), glutamate decarboxylase 65 kDa (GAD) glutamate decarboxylase autoantibodies (GADA) and IA‐2A with or without ZnT8A] in identifying children, adolescents and adults who progress rapidly to diabetes (within 5 years). Antibodies were determined by radiobinding assays during follow‐up of 6444 siblings and offspring aged 0–39 years at inclusion and recruited consecutively by the Belgian Diabetes Registry. We identified 394 persistently IAA+, GADA+, IA‐2A+ and/or ZnT8A+ relatives (6·1%). After a median follow‐up time of 52 months, 132 relatives developed type 1 diabetes. In each age category tested (0–9, 10–19 and 20–39 years) progression to diabetes was significantly quicker in the presence of IA‐2A and/or ZnT8A than in their joint absence (P < 0·001). Progression rate was age‐independent in IA‐2A+ and/or ZnT8A+ relatives but decreased with age if only GADA and/or IAA were present (P = 0·008). In the age group mainly considered for immune interventions until now (10–39 years), screening for IA‐2A and ZnT8A alone identified 78% of the rapid progressors (versus 75% if positive for ≥ 2 antibodies among IAA, GADA, IA‐2A and ZnT8A or versus 62% without testing for ZnT8A). Screening for IA‐2A and ZnT8A alone allows identification of the majority of rapidly progressing prediabetic siblings and offspring regardless of age and is more cost‐effective to select participants for intervention trials than conventional screening.
An Improved Certificateless Signature Scheme Secure in the Standard Model

In ASIACCS 2007, Liu et al proposed a certificateless signature scheme which is provably secure in the standard model. However, as we will show in this paper, the proposed scheme is insecure against a malicious-but-passive KGC attack. This implies that the malicious-but-passive KGC, which generates system parameters based on the information of the target user, can forge valid signatures for that signer without being detected. Furthermore, we propose an improved scheme that remedies the weakness of Liu et al's scheme. The improved scheme can be proven secure against malicious-but-passive KGC attack in the standard model.
Imaging anisotropic and viscous properties of breast tissue by magnetic resonance‐elastography

MR‐elastography is a new technique for assessing the viscoelastic properties of tissue. One current focus of elastography is the provision of new physical parameters for improving the specificity in breast cancer diagnosis. This analysis describes a technique to extend the reconstruction to anisotropic elastic properties in terms of a so‐called transversely isotropic model. Viscosity is treated as being isotropic. The particular model chosen for the anisotropy is appealing because it is capable of describing elastic shear anisotropy of parallel fibers. The dependence of the reconstruction on the particular choice of Poisson's ratio is eliminated by extracting the compressional displacement contribution using the Helmholtz–Hodge decomposition. Results are presented for simulations, a polyvinyl alcohol breast phantom, excised beef muscle, and measurements in two patients with breast lesions (invasive ductal carcinoma and fibroadenoma). The results show enhanced anisotropic and viscous properties inside the lesions and an indication for preferred fiber orientation. Magn Reson Med 53:372–387, 2005. © 2005 Wiley‐Liss, Inc.
AUTO-AJUDA ESPECIALIZADA STATE-OF-THE-ART SELF-HELP

Porto Alegre: Artmed,240 paginas.Robert Leahy e atualmente um dos maiores nomes da Terapia Cognitivo-Comportamental. Formado pelo Beck Institute, presidente da Associacao Inter-nacional de Psicoterapia Cognitiva e da Academia de Terapia Cognitiva dos Esta-dos Unidos, professor da Cornell University e editor associado do InternationalJournal of Cognitive Therapy, Leahy consegue aliar sua vasta experiencia clinica auma base solida de pesquisa e cientificidade em teorias cognitivas e doprocessamento da informacao.A secao de agradecimentos desse livro reflete o quanto ele pode ser conside-rado um compendio do estado da arte das pesquisas sobre preocupacao. O autorfaz questao de observar, por diversas vezes, que o conteudo apresentado e fruto deestudos nao apenas de seu grupo, mas de diversos centros de pesquisa que sededicam a investigar a preocupacao, o que permite ao leitor obter um somatoriode conhecimentos que se superpoem, de modo a criar uma complexa teoriaexplicativa dos processos subjacentes a preocupacao, bem como oferecer acesso atecnicas de tratamento cuja eficacia tem sido exaustivamente comprovada nosultimos anos.
Phase retrieval from impedance amplitude measurement

In this letter, we propose a numerical method for computing the phase spectrum of impedance. The developed method is based on the maximum entropy model (MEM) and enables one to retrieve the phase spectrum directly from an impedance amplitude spectrum. The validity of the method is tested with an input impedance measurement of a distribution transformer in the frequency band 100 kHz-30 MHz, where both the amplitude and the phase spectrum of the impedance are measured. According to the tests carried out, the method is useful and it may be applied, for example, in the research of active filters, power line communication, and electromagnetic interference.
The Acceptability and Feasibility of an HIV Preexposure Prophylaxis (PrEP) Trial With Young Men Who Have Sex With Men

Background:This study examined the feasibility of a combination prevention intervention for young men who have sex with men (YMSM), an anticipated target population for HIV preexposure prophylaxis (PrEP). Methods:Project PrEPare, a pilot study using a randomized 3-arm design, compared an efficacious behavioral HIV prevention intervention (Many Men, Many Voices—3 MV) alone, 3 MV combined with PrEP (tenofovir/emtricitabine), and 3 MV combined with placebo. Eligible participants were 18- to 22-year-old HIV-uninfected men who reported unprotected anal intercourse in the past year. Participants were screened for preliminary eligibility at youth venues and community organizations and were also referred through social networks. Laboratory screening determined final eligibility. Behavioral and biomedical data were collected at baseline and every 4 weeks thereafter for 24 weeks. Results:Sixty-eight youth (mean age = 19.97 years; 53% African American, 40% Latino) were enrolled; 58 were randomized. Self-reported medication adherence averaged 62% (range, 43%–83%), whereas rates of detectable tenofovir in plasma of participants in the emtricitabine/tenofovir disoproxil fumarate arm ranged from 63.2% (week 4) to 20% (week 24). There were 5 ≥ grade 2 adverse events possibly/probably related to the study medication. Sexual risk behavior declined from baseline to week 24 in all study arms. Conclusions:The feasibility of enrolling at-risk youth, particularly young men who have sex with men of color, into Project PrEPare has been demonstrated. The acceptability of the group intervention along with counseling and testing was high. Self-reported medication adherence and corresponding plasma drug concentrations were low indicating the need for enhanced adherence counseling. Exploration of PrEP use among youth in nonrandomized open label trials is warranted.
Clinical Efficacy and Quality of Life Follow-Up of Reconstructive Endovascular Therapy for Acute Intracranial Vertebral Artery Dissection Aneurysms

Background: Intracranial vertebral artery dissection aneurysms (VADAs) may cause acute ischemia or hemorrhage, in which case urgent endovascular treatment will be needed. Although the majority of patients obtain a good functional outcome after surgery, a surprising finding has been a poor quality of life (QOL) in follow-up. The purpose of this study was to evaluate clinical efficacy in reconstructive endovascular therapy for acute intracranial VADAs and to analyze the factors contributing to subsequent QOL. Methods: In this prospective study, 33 consecutive VADA patients with subarachnoid hemorrhage were recruited for comparison with 37 VADA patients with posterior circulation cerebral ischemia. All VADA patients were treated using a reconstructive strategy. Clinical, radiological, neurological, and cognitive data, as well as QOL, were assessed at admission and 6 months after surgery. Stoke Specific Quality of Life (SS-QOL) was evaluated for patients with good functional outcome [modified Ranking Scale (mRS) scoring 0-2] for subgroup analysis. Predictors for QOL at follow-up were analyzed by regression model. Results: Immediate angiography after surgery showed complete VADA obliteration in 57 (81.4%) patients and partial obliteration in 13 (18.6%) patients. Three (4.3%) cases suffered from perioperative complications, comprising two cases of stent thrombosis in the hemorrhagic group and one case of posterior inferior cerebellar artery occlusion in the ischemic group. Twenty-five (75.8%) patients in the hemorrhagic group and 30 (81.1%) patients in the ischemic group had a favorable outcome (mRS scoring 0-2) at 6-month follow-up. Follow-up angiography displayed that one case of recurrence occurred separately in both groups. Fifteen of the 33 hemorrhagic patients (45.5%) and 19 of the 37 ischemic patients (51.4%) rated QOL at follow-up as bad (SS-QOL score ≤ 3.9) despite a good functional outcome. Severity of neurological disorder and impaired neurocognition at baseline in VADA patients are proved to be independent predictors for the decline of QOL according to regression analysis. Conclusion: Reconstructive endovascular therapy for acute intracranial VADAs is a safe and effective method with a low complication rate. VADAs lead to impaired QOL at 6-month follow-up, which is attributable to multiple factors. This study demonstrated that neurological and cognitive status at baseline is of significant importance for QOL after VADAs.
The Core Language of Aldwych

Aldwych is a general purpose programming language which we have developed in order to provide a mechanism for practical programming which can be thought of in an inherently concurrent way. We have described Aldwych elsewhere [13] in terms of a translation to a concurrent logic language. However, it would be more accurate to describe it as translating to a simple operational language which, while able to be represented in a logic-programming like syntax, has lost much of the baggage associated with “logic programming”. This language is only a little more complex than foundational calculi such as the pi-calculus. Its key feature is that all variables are moded with a single producer, and some are linear allowing a reversal of polarity and hence interactive communication.
Rheumatic Fever: From Sore Throat to Autoimmune Heart Lesions

Molecular mimicry between streptococci and heart components has been proposed as the triggering factor leading to autoimmunity in rheumatic heart disease (RHD). In this review, we present data from cellular autoimmune responses, focusing on the interactions between HLA class II molecules, streptococcal peptides and heart tissue proteins and T-cell receptor (TCR) usage. HLA-DR7DR53 associated with DQ molecules seem to be related with the development of valvular lesions in severe RHD patients. DR7DR53 molecules were also involved in the recognition of an immunodominant M5 peptide in these patients. T cells infiltrating RHD hearts displayed several oligoclonal expansions. Intralesional T-cell clones presenting identical TCR-BVBJ AVAJ and -CDR3 sequences were able to recognize several antigens with little or low homology, showing an intramolecular degenerate pattern of antigen recognition. Peripheral blood mononuclear cells of rheumatic fever (RF) patients produced proinflammatory cytokines, and intralesional mononuclear cells from severe RHD patients produced predominantly Th1-type cytokines. These results illustrate the complex mechanisms leading to heart tissue damage in RF/RHD patients.
InGaP PHEMTs for wireless power applications

This paper shows that we have successfully fabricated a InGaP PHEMT device with a tight threshold voltage distribution of 22 mV by using InGaP as barrier layer material. Fabricated device performance is similar to our standard AlGaAs PHEMT for low voltage operation. A 15 mm device delivers 30 dBm output power, 10.2 dB associated gain, and 67% power added efficiency at 1 dB compression point while operated at 3.5 V and 1.9 GHz.
Design study on a SAR ADC using an incremental ΣΔ-DAC

The use of the charge redistribution DAC, which relies on capacitive element matching, limits the achievable effective resolution of nowadays Successive Approximation Register (SAR) ADCs below about 13 effective bits. To overcome this limitation, this paper discusses the implementation of an incremental sigma delta (I-SD) DAC in the feedback path of a 16-bit SAR ADC. The proposed DAC uses an intrinsically linear one-bit output from a digital SD modulator, which is passed to an analog reconstruction filter. The filter architecture including an FIR part and active integrators is implemented on transistor level. The circuit is implemented using TSMC's 40nm CMOS technology. The I-SD-DAC achieves 100 dB SFDR at a sampling frequency of 500 kHz. A behavioral level simulation of a 16-bit SAR ADC loop employing the designed schematic I-SD-DAC loop achieves an SFDR of 96.2 dB and an SNDR of 83.5dB with 34.18 kS/s.
Projeto de Controladores para o Conversor Cúk para Implementação de Métodos de Carga de Bateria.

This work presents the use of a digital controller to control the battery charging method: constantcurrent and constant-voltage. The experiment consists of a Cú power converter applied as a battery charger and two programmable control meshes. A proportional-integral compensator was used as a model for the programming of the voltage and current meshes, in order to show the flexibility that the digital control has in relation to the analogical one, that can hardly meet more than one charging method . Keywords— Battery charger, Digital Control, Charging Methods. Resumo— Este trabalho apresenta a utilização de um controlador digital para o comando do método de carga de bateria: corrente-constante e tensão-constante. O experimento consiste em um conversor de potência Cúk aplicado como carregador de baterias e duas malhas de controle programáveis. Foi utilizado um compensador proporcional-integral como modelo para a programação das malhas de tensão e de corrente, com o objetivo de mostrar a flexibilidade que o controle digital possui em relação ao analógico, que dificilmente consegue atender mais de um método de carga. Palavras-chave— Carregador de baterias, Controle Digital, Métodos de Carga.
Anisotropy in diffusion‐weighted MRI

Diffusional anisotropy of water protons, induced by nonrandom, directional barriers which hinder or retard water motion, is measurable by MRI. Faster water diffusion was observed when the diffusion‐sensitizing gradient direction paralleled the long axes of white matter tracts, indicative of fewer bamers to water motion. Diffusion perpendicular to this 3xis was as much as four times slower. Anisotropy was seen pre‐ and postmortem in all axial, sagittal, and coronal planes, with and without cardiac gating. Ordering has also been observed in feline optic nerve and in human peripheral nerves. Utilization of this technique can greatly improve understanding and assessment of demyelinating disorders, of white matter infarcts and neoplasms, and of neonatal brain and spinal cord development. © 1991 Academic Press, Inc.