Miracle-dz/UniFAR-FTUs huggingface dataset:
DeepIce: A Deep Neural Network Approach To Identify Ice and Water Molecules

Computer simulation studies of multiphase systems rely on the accurate identification of local molecular structures and arrangements in order to extract useful insights. Local order parameters, such as Steinhardt parameters, are widely used for this identification task; however, the parameters are often tailored to specific local structural geometries and generalize poorly to new structures and distorted or undercoordinated bonding environments. Motivated by the desire to simplify the process and improve the accuracy, we introduce DeepIce, a novel deep neural network designed to identify ice and water molecules, which can be generalized to new structures where multiple bonding environments are present. DeepIce demonstrates that the characteristics of a crystalline or liquid molecule can be classified using as input simply the Cartesian coordinates of the nearest neighbors without compromising the accuracy. The network is flexible and capable of inferring rotational invariance and produces a high predictive accuracy compared to the Steinhardt approach, the tetrahedral order parameter and polyhedral template matching in the detection of the phase of molecules in premelted ice surfaces.
Immunization withgastric H +/K+ -ATPase induces areversible autoimmune gastritis

SUMMARY Thegastric H+/K+-ATPase hasbeenimplicated asamajorautoantigen inpernicious anaemiain humansandinthymectomy-induced autoimmune gastritis inmice.Herewe haveshownthat autoimmune gastritis can begenerated bydirect immunization ofnon-thymectomized BALB/c micewithmouse gastric H+/K+-ATPase incomplete Freund's adjuvant. Thegastritis was characterized byinfiltration ofthegastric submucosa andmucosa withmacrophages, CD4+and CD8+ Tcells, andB cells andbycirculating autoantibodies totheH+/K+-ATPase. The mononuclear infiltrate within thegastric mucosa was accompanied bylossofparietal and zymogenic cells andaccumulation ofsmallimmature epithelial cells. Splenocytes fromgastritic miceadoptively transferred gastritis tonaiverecipients. Cessation ofimmunization resulted in decrease inautoantibody titre andregeneration ofparietal andzymogenic cells. Theresults directly confirm thatthegastric H+/K+-ATPase isthecausative autoantigen inthegenesis of autoimmune gastritis. Recovery ofthelesion following cessation ofimmunization suggests that homeostatic mechanisms can reversea destructive autoimmune process.
Patients With Dermatomyositis/Polymyositis During Pregnancy

Dermatomyositis (DM) and polymyositis (PM) belong to the group of inflammatory muscle diseases characterized by inflammation of the muscles. These diseases are usually studied together as dermatomyositis/polymyositis (DM/PM). Regarding pregnant patients affected with DM/PM, important individual issues arise as: (1) Do female patients with DM/PM successfully complete pregnancy, giving birth to healthy infants or is there high risk of complications for both mother and fetus? (2) Is there a connection between activity of DM/PM and high risk of complications during gestation? (3) Does pregnancy increase the risk of DM/PM activation? (4) Does pregnancy increase the risk of DM/PM relapse during or right after gestation? After our attempt to answer these questions, we will refer to the treatment of the disease during pregnancy and the effect it could have on the completion of pregnancy.
Aromatherapy from the perspective of traditional Iranian medicine and modern medicine

Background and Purpose: Aromatherapy is one of the most commonly used treatments in traditional medicine and modern medicine. Essential oils are the basis of aromatherapy. Different research has been done in traditional medicine and modern medicine for aromatherapy. But since there was no comparative study in this regard, this article is presented. Methods and Materials: The research method was descriptive and survey review. Different printed and electronic resources in Farsi and English related to aromatherapy in traditional medicine and modern medicine and their key words were searched. Conclusion: The aromatherapy has long been considered in ancient texts and today it is widely used in the prevention and treatment of many physical and mental disorders. healthrelated individuals should be able to identify key elements related to the safety and efficacy of the aromatherapy. In this case, they will be able to provide counseling and training to patients.
The MDR1/ABCB1 gene rs 1045642 polymorphism in colorectal cancer

Introduction Colorectal cancer (CRC) is one of the most frequently diagnosed tumors in Western countries. CRC is a heterogeneous group of tumors with regards to its molecular pathogenesis and genetic factors. Both genetic variations and anthropometric factors may affect morbidity in CRC patients. The aim of this study was to assess the impact of multidrug resistance 1/ATP-binding cassette sub-family B member 1 gene (MDR1/ABCB1) polymorphism rs1045642 and general anthropometric factors on the CRC risk. Material and methods The study included 250 patients who underwent colonoscopy and polypectomy between 2006 and 2013 in a single endoscopy unit in Warsaw, Poland. Results The CRC was diagnosed in 50 individuals, and 200 patients were included in the control group. Cases and controls were matched for mean age and sex (p > 0.05). Factors that were found to significantly increase the risk of CRC were ulcerative colitis (8/35 in the CRC group vs. 8/181 in the control group; p = 0.001), family history of CRC (11/33 vs. 26/172; p = 0.05), and diabetes mellitus (12/34 vs. 28/170; p = 0.04). Allele T of the rs 1045642 polymorphism was more frequently present in CRC cases (in both a co-dominant and recessive model) and in males (in a co-dominant model), although these associations were not statistically significant (p > 0.05). Conclusions The MDR1/ABCB1 gene polymorphism rs 1045642 may be involved in the pathogenesis of CRC and this relationship may be sex-specific for males. However, further population studies are necessary to assess this relationship.
[BP.04.05] PREVALENCE AND CLINICAL PHENOTYPE OF PRIMARY ALDOSTERONISM IN PRIMARY CARE HYPERTENSIVES

Objective: Despite being widely recognized as the most common form of secondary hypertension, the true prevalence of primary aldosteronism (PA) and its main subtypes, aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia (BAH), among the general hypertensive population remains a matter of debate. The present study was undertaken to determine the prevalence and clinical phenotype of PA in a large cohort of unselected hypertensive patients, consecutively referred to our Hypertension Unit, by 19 general practitioners. Design and method: Patients were screened for PA using the serum aldosterone to plasma renin activity ratio after withdrawal from all interfering medications and PA was diagnosed according to the Endocrine Society guidelines. The diagnosis was confirmed/excluded by an i.v. saline infusion test or captopril challenge test and subtype differentiation was performed by adrenal CT scanning and adrenal vein sampling (AVS) using strict criteria to define both successful cannulation and lateralization of aldosterone production. Results: A total of 1,672 primary care hypertensive patients, 569 newly diagnosed hypertensives and 1,103 patients already diagnosed with arterial hypertension, were included in the study. A total of 99 patients (5.9%) were diagnosed with PA and conclusive subtype differentiation by AVS was made in 91 patients (27 patients with an APA and 64 patients with BAH). The overall prevalence of PA increased with the severity of hypertension, from 3.9% in hypertensives stage I to 11.8% in hypertensives stage III. Patients with PA more frequently displayed target organ damage and cardiovascular events compared to non-PA hypertensives, independent of confounding variables. Conclusions: The results from the present study demonstrated that PA is a frequent cause of secondary hypertension even in the general hypertensive population and indicates that the majority of hypertensive patients should be screened for PA.
Neuropathy in cases of Hypothyroidism as Confirmed by Motor Nerve Conduction Studies: A Prospective Study in a Tertiary Care Hospital

Background: Thyroid hormone play important role in development of Central Nervous System and in myelination of neurons. Patients of hypothyroidism may suffer from peripheral nervous dysfunction. Aim of our study is to find out the neuropathy in hypothyroidism. Methods: This prospective study was conducted on 40 subjects, out of which n=20 were euthyroid control and n=20 were hypothyroid. The Study was performed in the Medicine department of Saraswathi Institute of Medical Sciences, Hapur in collaboration with the department of Physiology at G.S. Medical College, Hapur. MNCV and latency of Median, Ulnar, and Common Peroneal nerve of both upper and lower limb were done in patients of Hypothyroidism and in Control subjects. Results: Significant bilateral decrease is observed in the MNCV of the Median Nerve in Hypothyroid subjects as compared to the control subjects. Also, there is Significant bilateral increase in the Motor Latency of the Median Nerve in Hypothyroid subjects as compared to the control subjects. Conclusion: Hypothyroidism cause significant decrease in MNCV of Median Nerve as well as increase in Motor latency in Median Nerve.
Memristor-CMOS Hybrid Circuit for Temporal-Pooling of Sensory and Hippocampal Responses of Cortical Neurons

As a software framework, Hierarchical Temporal Memory (HTM) has been developed to perform the brain’s neocortical functions, such as spatial and temporal pooling. However, it should be realized with hardware not software not only to mimic the neocortical function but also to exploit its architectural benefit. To do so, we propose a new memristor-CMOS (Complementary Metal-Oxide-Semiconductor) hybrid circuit of temporal-pooling here, which is composed of the input-layer and output-layer neurons mimicking the neocortex. In the hybrid circuit, the input-layer neurons have the proximal and basal/distal dendrites to combine sensory information with the temporal/location information from the brain’s hippocampus. Using the same crossbar architecture, the output-layer neurons can perform a prediction by integrating the temporal information on the basal/distal dendrites. For training the proposed circuit, we used only simple Hebbian learning, not the complicated backpropagation algorithm. Due to the simple hardware of Hebbian learning, the proposed hybrid circuit can be very suitable to online learning. The proposed memristor-CMOS hybrid circuit has been verified by the circuit simulation using the real memristor model. The proposed circuit has been verified to predict both the ordinal and out-of-order sequences. In addition, the proposed circuit has been tested with the external noise and memristance variation.
Densité mammaire et cancer du sein

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Densité mammaire et cancer du sein A. Tardivon
Massive Splenomegaly in Pregnancy: Case Report

A 33-year-old primigravida presented to an appointment at a high-risk prenatal outpatient service due to a history of splenomegaly. Her spleen occupied of the abdominal cavity and shifted the uterus to the right side of the abdomen. During investigation, an intrauterine growth restriction (IURG) and a series of other clinical complications were discovered. We admitted her to inpatient care at 28 + 1 weeks’ gestation for a better investigation of her extensive splenomegaly and for pregnancy monitoring, with a further successful delivery.
Dragotcytosis: Elucidation of the Mechanism for Cryptococcus neoformans Macrophage-to-Macrophage Transfer

Key Points C. neoformans transfers between macrophages in coordinated exocytosis/phagocytosis. Opsonin receptors are used for the transfer process. C. neoformans must be viable for the transfer process to occur. Cryptococcus neoformans is a pathogenic yeast capable of a unique and intriguing form of cell-to-cell transfer between macrophage cells. The mechanism for cell-to-cell transfer is not understood. In this study, we imaged mouse macrophages with CellTracker Green 5-chloromethylfluorescein diacetate–labeled cytosol to ascertain whether cytosol was shared between donor and acceptor macrophages. Analysis of several transfer events detected no transfer of cytosol from donor-to-acceptor mouse macrophages. However, blocking Fc and complement receptors resulted in a major diminution of cell-to-cell transfer events. The timing of cell-to-cell transfer (11.17 min) closely approximated the sum of phagocytosis (4.18 min) and exocytosis (6.71 min) times. We propose that macrophage cell-to-cell transfer represents a nonlytic exocytosis event, followed by phagocytosis into a macrophage that is in close proximity, and name this process Dragotcytosis (“Dragot” is a Greek surname meaning “sentinel”), as it represents sharing of a microbe between two sentinel cells of the innate immune system. Visual Abstract
Increasing Mental Health Engagement From Primary Care: The Potential Role of Family Navigation

Linking children to mental health care is challenging; in this review, we explore the role that navigators can play in increasing family engagement. Early engagement in mental health intervention is critical, yet the vast majority of children who are experiencing mental health concerns are not receiving needed services. Pediatric primary care clinics have been recognized as an ideal setting in which to identify and address mental health problems early, although engagement in mental health services within primary care and in community-based settings remains low. Navigators, or individuals with experience in navigating the mental health system, have been highlighted as promising partners in efforts to improve engagement in mental health services. Navigation has a growing body of research support among adults and in targeting medical concerns, but there has been limited research on integrating family navigators into pediatric primary care settings to address mental health concerns. Despite this gap in the evidence base, we believe there is significant promise for the use of this model in addressing children’s mental health needs. In this report, we discuss factors contributing to high levels of unmet mental health needs and low levels of engagement in mental health services, the role that navigators can play in increasing engagement in mental health care, and implications and recommendations related to integrating mental health–focused family navigators into pediatric primary care settings.
Correlation between Severity of Alcohol Dependence with Age of Onset and Family History.

INTRODUCTION: Alcoholism is one of the most threatening of present health Problems in most of the countries. It has led to enormous burden on health Care facilities and nations economy. The Global Burden of Disease Project Estimated alcohol to be responsible for 1.5% of all deaths and 3.5% of the Total Disability Adjusted Life Years (dalys)1. Epidemiological studies in India have shown a prevalence of 16-50 % rate for alcoholism, even Though India is considered to be a “Dry” culture.2 Lewis et al3 (1983) demonstrated that male sex; antisocial Personality and family history of alcoholism increased the risk of severity Of alcoholism. Genetic studies have found a three to four fold increased Risk for severity of alcohol related problems in close relatives of alcohol Patients. When compared to general population, alcoholics have significant Family history of alcoholism. First degree relatives of alcoholics have four Fold increased risk and second degree relatives have two fold increased risk Of alcoholism when compared to general population. Subjects with positive Family history of alcoholism had an increased severity of alcohol- related Problems; however, it was difficult to say whether this propensity is Genetic or environmental or a combination of the two4. The twin studies originally proposed by Francis Galton compared Identical twins with fraternal twins in which one of the twins had Alcoholism and found that monozygotic twins were significantly Concordant with regard to the quantity of alcohol consumed. The twin Studies complemented by the adoption studies have shown that alcoholism Is heritable, but the pattern of inheritance was not a simple one, it was Complex and multifactorial in nature.5,6 The studies done internationally7 indicate that alcoholism is more Severe when familial. Also there is evidence that the familiality also Impacts on the AGE OF ONSET8. Additionally, it is established that the Younger the AOO more severe the alcoholism9. This has lead to further Explorations into what is inherited10,11 and what mediates the heightened Severity in familial Alcoholism12. While a few Indian studies13,14,15 Have Done similar explorations, the relationship per se amongst Familiality, Age Of Onset and Severity of Alcoholism.
Whether viable and dead probiotic are equally efficacious

Purpose Consumer inclination towards probiotic foods has been stimulated due to well-documented evidence of health benefits of probiotic-containing products and consumer demand for natural products. It is assumed that the viability and metabolic activities of probiotics are essential for extending health benefits and for successful marketing of probiotics as a functional food. The purpose of this paper is to demonstrate that even dead or inactivated probiotic cells could extend health benefits, indicating that probiotic viability is not always necessary for exhibiting health benefits. Design/methodology/approach Attempt has been made to review the literature on the status of probiotic foods available in the world market, their impact on the gut flora and the various factors affecting their viability. Both review and research papers related to efficacy of inactivated, killed or dead probiotic cells towards health benefits have been considered. Keywords used for data search included efficacy of viable or killed, inactivated probiotic cells. Findings The reviewed literature indicated that inactivated, killed or dead probiotic cells also possess functional properties but live cells are more efficacious. All live probiotic cultures are not equally efficacious, and accordingly, dead or inactivated cells did not demonstrate functional properties to extend health benefits to all diseases. Originality/value Capability of non-viable microorganisms to confer health benefits may attract food manufacturers owing to certain advantages over live probiotics such as longer shelf-life, handling and transportation and reduced requirements for refrigerated storage and inclusion of non-bacterial, biologically active metabolites present in fermented milks’ fraction as dried powders to food matrixes may result in the development of new functional foods.
DISPOSITIVOS DE ASSISTÊNCIA VENTRICULAR E CUIDADOS DE ENFERMAGEM

Objective: describing the functioning, benefits and complications associated with the use of ventricular assist devices and identifying the interventions performed by nurses in the care of patients using this device, according to presented evidence. Method: an integrative review of articles collected in health databases conducted in February 2015. The descriptors used were heart diseases, heart-assist devices and nursing. We identified 34 articles, which were then submitted to thematic analysis. Results: ventricular assist devices function as mechanical pumps promoting adequate cardiac output. Their main benefit is hemodynamic stabilization. The most common complication is infection. Health education, emotional support, outpatient care and curative care are the main care actions performed by nurses. Conclusion: evidence confirms improvement in survival rates of patients with severe heart failure with the use of ventricular assist devices, reiterating the importance of expanding this technology in Brazil as a possibility for treatment. DESCRIPTORS: Cardiac disorders. Cardiac insufficiency. Artificial heart. Nursing. Cardiovascular nursing. Nursing care. http://dx.doi. org/10.1590/0104-07072017000980016
Admission to NICU in air is more likely if nasal High Flow is used for stabilisation in preterm babies compared to face mask CPAP

Objective. To examine the success of stabi-lisation and the short term outcomes from the routine use of nasal high flow (nHF) on an unselected cohort of babies in the deliv-ery room (DR). Design. Retrospective single-centre study Setting. Single-centre neonatal intensive care unit (NICU)Patients. Infants born at < 32 weeks gesta-tionInterventions. Stabilisation and transfer to NICU of an unselected cohort of babies us-ing nHFMain outcome measures. Success of sta-bilisation defined by successful transfer on nHF and clinical measures of stability at admission to NICU, including oxygen requirement, admission temperature, sur-factant requirement, short term outcomes and whether infants were sustained on nHF by 72 hours of age. Results. There were 133 eligible babies. 54 were commenced on nHF in the DR (Group A), 47 were stabilised by face mask CPAP (continuous positive airway pressure) (Group B), 26 were intubated (Group C); 6 required only minimal res-piratory support (Group D). Median ma-turity varied between the groups (Group A 27+5 weeks, Group B 30 weeks, Group C 26+2 weeks, Group D 31+5). 72% of Group A and 75% of Group B remained on nHF for 72 hours (P=0.82). Fewer ba-bies received surfactant in Group A versus Group B (29% vs 35%; P=0.67), however groups were not matched for maturity dif-ferences and Group A were significantly less mature and of lower birthweight (both P<0.001). Group A were significantly more likely to be in air at admission than Group B (P=0.03). Conclusion. Preterm babies can be suc-cessfully stabilised and sustained on nHF. The use of nHF for immediate stabilisation appears to be effective and, in this study, led to significantly more babies being in air on admission to the NICU compared to face mask CPAP stabilisation.
Description et impact du doppler transcrânien en réanimation chez 152 enfants sans traumatisme crânien

Contexte : le doppler transcrânien (DTC) permet de detecter une modification de la vascularisation cerebrale au lit du patient. En reanimation pediatrique, son utilisation et son impact en pratique courante sont peu connus. Materiel et Methodes : cette etude prospective et multicentrique a evalue les caracteristiques des patients (0-18ans) non traumatises crânien ayant eu un DTC et son impact d’apres l’operateur. Un questionnaire standardise etait complete pour chaque DTC realise. Les facteurs influencant l’impact diagnostique et therapeutique du DTC etaient identifies. Resultats : 152 enfants ont ete inclus. Le DTC etait realise chez 6.7% des patients admis pendant la periode d’inclusion. 70% des patients presentaient un diagnostic principal neurologique. Le DTC etait realise pour surveillance d’une souffrance neurologique dans 56% des cas. Parmi les anomalies DTC suspectees avant l’examen, l’hypertension intracrânienne etait plus frequemment recherchee par les jeunes operateurs et l’hyperperfusion par les plus experimentes. Une discordance entre l’interpretation des valeurs du DTC et les normes publiees etait retrouvee chez 116 patients (76%). Le DTC avait un impact dans 86% des cas, avec un impact fort dans 64% des cas. L’impact therapeutique etait plus frequent chez les patients presentant une dysfonction hemodynamique (OR 6.4 ; p=0.007) et pour les operateurs peu experimentes (OR 0.39 ; p=0.012). Conclusion : le DTC a un impact important dependant des operateurs et de la gravite des patients. Son interpretation est complexe. L’amelioration de l’usage du DTC est necessaire.