Miracle-dz/UniFAR-FTUs huggingface dataset:
Manufacturable Parasitic-Aware Circuit-Level FETs in 65-nm SOI CMOS Technology

This letter reports the statistical analysis of circuit-level FET high-speed performance in 65-nm silicon-on-insulator CMOS technology. Practical performance metrics are derived from full 300-mm wafer measurements. The proposed circuit-level layout wiring parasitics-aware FET reflects realistic FET that is placed in circuits. Its measurement and model are directly applicable to circuit design in conjunction with multiple layers of yield and manufacturability considerations. A stretched gate-pitch NFET design shows an average current gain cutoff frequency fT of 250 GHz, with 7.6% standard deviation, 6.7% mismatch standard deviation, and maximum fT of 307 GHz. The proposed characterization methodology will become more relevant to technologies beyond 65 nm.
Rutin improves glucose homeostasis in streptozotocin diabetic tissues by altering glycolytic and gluconeogenic enzymes

The role of rutin on carbohydrate metabolism in normal and streptozotocin (STZ)‐induced diabetic rats was investigated in the present study. Administration of STZ led to a significant (p <0.05) increase in fasting plasma glucose and a decrease in insulin levels. The content of glycogen significantly (p <0.05) decreased in liver and muscle, but increased in kidney. The activity of hexokinase decreased whereas the activities of glucose‐6‐phosphatase and fructose‐1,6‐bisphosphatase significantly (p <0.05) increased in the tissues. Oral administration of rutin (100 mg/kg) to diabetic rats for a period of 45 days resulted in significant (p <0.05) alterations in the parameters studied but not in normal rats. A decrease of plasma glucose and increase in insulin levels were observed along with the restoration of glycogen content and the activities of carbohydrate metabolic enzymes in rutin‐treated diabetic rats. The histopathological study of the pancreas revealed the protective role of rutin. There was an expansion of the islets and decreased fatty infiltrate of the islets in rutin‐treated diabetic rats. In normal rats treated with rutin, we could not observe any significant change in all the parameters studied. Combined, these results show that rutin plays a positive role in carbohydrate metabolism and antioxidant status in diabetic rats. © 2006 Wiley Periodicals, Inc. J Biochem Mol Toxicol 20:96–102, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20117
Relação peso-comprimento e fator de condição relativo (Kn) do pirarucu Arapaima gigas Schinz, 1822 (Arapaimidae) em cultivo semi-intensivo no estado do Amazonas, Brasil.

O pirarucu Arapaima gigas (Osteoglossiformes, Arapaimidae), peixe da bacia amazonica, apresenta alta taxa de crescimento e tolerância a alta densidade de estocagem, tem rusticidade ao manuseio e aceita alimentacao artificial quando treinado no inicio da vida, caracteristicas relevantes para o cultivo de peixe. Neste estudo, a relacao peso-comprimento (W=a·Lb) e o fator de condicao relativo (Kn) foram estimados para alevinos, juvenis e jovens de pirarucus cultivados em piscicultura semi-intensiva no municipio de Manacapuru, estado do Amazonas, na Amazonia central, Brasil. Alevinos foram previamente treinados para aceitar racao comercial durante no inicio da vida e depois foram alimentados com racao para peixes contendo 45% de proteina bruta. A equacao relacao peso-comprimento mostrou crescimento do tipo isometrico, com valor da constante de regressao (b) igual 3,068. O Kn variou de 0.811 a 1.170 (media de 1.007 ± 0.059) e esses valores elevados indicaram boas condicoes corporais dos peixes nas condicoes cultivadas.
Quantitative studies on the uptake and metabolism of estrogens and progesterone by human endometrium.

Rates of entry of estrone ( E1, estradiol (E2), progesterone (P), 20αdihydroprogesterone (20αDHP), estrone sulfate (E1S) and estradiol-3-sulfate (E2S) from buffer solutions into slices of human endometrium were measured in multiple-tracer continuous-flow incubations of the tissue. The fraction of perfused P entering the cells was found to be similar to that of E1 and E2. Increases in the concentrations of E2 in the medium to 5 μg/ml did not alter the fraction of perfused E1 and E2 going into cells. Estrone sulfate and E2S entered readily into endometrial cells and were completely converted to E1 and E2. Rates of interconversion between ElS-E2S, E1-E2 and P-20αDHP were measured. The conversion of E1 to E2 was relatively increased by the addition of E2 to the medium. A large fraction of E1 and P entering the tissue was released to the medium while E2 and 20αDHP left the cells only after being converted to the corresponding ketonic steroids. Consequently, the net uptake of E2 and 20αDHP was larger than the n.
Generalised multiuser detection in TD-CDMA

We describe how intercell interference can be mitigated in the uplink of UTRA TDD (TD-CDMA). The intercell interference mitigation technique is based on reusing existing multiuser detector architectures that are derived from linear receivers. Through simulation results we determine the efficiency of the scheme when operating under different channel conditions, with different numbers of users and different levels of intercell interference. Using a simple TD-CDMA uplink capacity equation we demonstrate the potential performance improvement Finally, we present experimental results from a TD-CDMA system that has intercell interference mitigation enabled.
Trends in the Care of Diabetic Macular Edema: Analysis of a National Cohort

Purpose To evaluate how the monitoring and treatment for diabetic macular edema (DME) has changed in a national sample. Design Retrospective cohort study. Methods Setting: Administrative medical claims data from a large, national U.S. insurer. Study population: Beneficiaries of a U.S. insurance company. Observation procedures: All incident cases of DME were found. Those in years 2002/3, 2006 and 2010 were followed for a 2-year observation period and those from 2009, 2010 and 2011 for a 1-year observation period. Main Outcome Measures: Types and frequencies of treatment were tallied and compared over each of the cohorts. Results Two-year cohorts had 233, 251 and 756 patients in 2002/3, 2006 and 2010 respectively. One-year cohorts had 1002, 1119 and 1382 patients in 2009, 2010 and 2011, respectively. Both percentage of patients receiving therapy and number of treatments given increased across the 2-year cohorts for both focal laser and anti-vascular endothelial growth factor (anti-VEGF) (p<0.001). The highest use of anti-VEGF agents in any of the cohorts was in the 2011 1-year group that only averaged 3.78 injections. Focal laser was used 2.5x as frequently as anti-VEGF injections in the most recent cohorts with only a high of 14.0% of DME patients receiving anti-VEGF therapy in any of the cohorts. Conclusion Regardless of treatment modality (laser or injection) DME patients received vastly fewer treatments than patients in randomized control trials. Despite the proven superior visual outcomes of anti-VEGF agents over focal laser in DME, focal laser was still used more frequently.
CURVED.IT: A design tool to integrate making with curved folding into digital design process

The act of changing the direction of a sheet surface along a non-straight curve is a specific case of curved folding. From an architectural point of view, curved folding is an exciting operation. One or a couple of operation can generate highly complex shell-like spatial enclosure. From a digital design perspective, the implementation of curved folding with the built-in toolsets of available computer-aided design softwares is a challenging problem. The equilibrium state of curved folded geometry is needed to be found with a computational form-finding strategy. To use curved folding as a digital design operation, we introduce a new tool through developing a digital procedure for form-finding. The tool we develop can enable the experimentation with curved folding in the early stage of design process and facilitate the subsequent design development. In this article, we briefly present the literature focusing on curved folding in computational geometry, as well as the scope and description of a subclass of curved folding operation. Then, we introduce a digital tool, CURVED.IT through a design manual for its implementation and an algorithmic framework for its extension. Lastly, we discuss the design examples generated by CURVED.IT, and the potentials of the tool.
Multi-parameter health monitoring watch

This paper presents the design, implementation and test of a watch with the capability to measure multiple physiological signals, such as photoplethysmography (PPG), electrocardiography (ECG), and some physiological parameters extracted from PPG and ECG. Based on the PPG and ECG signals, the pulse rate and heart rate could be extracted respectively. Moreover, the pulse transmit time (PTT) could be extracted combining PPG and ECG, which was the key to calculate blood pressure (BP). The circumstance conditions (temperature, humidity and barometric pressure) were detected and displayed on the screen. A motion state was used to toggle the watch screen. Meanwhile all data measured could be sent to an android smart phone, using a Texas Instruments' (TI's) Bluetooth low energy chip CC2540. The PPG wave, ECG wave, heart rate, as well as the systolic blood pressure (SBP) and diastolic blood pressure (DBP) can be displayed on the android client in real time. Compared with the sport band and other smart watches, this multi-parameter health monitoring watch had the advantage of monitoring more parameters. We had made a test to compare this watch with standard equipment, Benavidez T5 and SUNTECH OSAR2, and the result showed that the relative error of heart rate, pulse rate, SBP and DBP against reference were 1.76 ±1.64bpm, 1.76 ±1.64bpm, 4.01 ± 2.75 mmHg, 4.64 ± 3.31 mmHg. These results demonstrated that this watch has a broad prospect in the field of mobile health care.
Development of an environmental DNA method for monitoring freshwater fish communities using metabarcoding

The choice the metabarcode and compilation of the curated reference database are important methodological considerations for metabarcoding. Two curated reference databases (Cytb and 12S) of UK freshwater fish werecompiled with a reproducible workflow. The reproducible workflow allows updating or adding new sequences into the reference databases at any time and can also be applied to generate local reference databases for other fish communities and in fact other taxonomic groups and markers. Moreover, two metabarcoding primer pairs targeting different mitochondrial genes have been fully in silico tested against the curated reference databases, and in vitro on 22 species and 10 mock communities. The data of mock communities were analysed with a custom reproducible metabarcoding bioinformatics analysis pipeline (metaBEAT). Except the potential primer bias with nine-spined stickleback Pungitius pungitius when using the Cytb primes targeting 412-bp region, together with two marker-specific curated reference databases and metaBEAT, these two metabarcoding primer pairs are selected for metabarcoding studies to investigating other eDNA questions. 1 Partial results of this chapter have been published as Supporting Information in Hänfling, B. , Lawson Handley, L. , Read, D.S. , Hahn, C. , Li, J., Nichols, P., Blackman, R.C. , Oliver, A. & Winfield, I.J. (2016) Environmental DNA metabarcoding of lake fish communities reflects long-term data from established survey methods. Molecular Ecology, 25, 3101-3119. https://doi.org/10.1111/mec.13660
Optimization of DSKF-based algorithm for sensorless SFO-SM control of IMs using differential evolution

This paper proposes to use a differential evolution (DE) algorithm to obtain the optimal covariance matrices of a new reduced delayed-state Kalman filter (DSKF) based algorithm to realize sensorless induction motor drives. We propose to use a novel simple stator flux oriented-sliding mode (SFOSM) control scheme in conjunction with the optimized DSKF-based algorithm, estimating the stator flux linkage components. This control scheme has closed loops of torque and stator flux without PI-type controllers and a minimum number of controller gains is required to obtain good performance without fine tuning. The DSKF-based algorithm estimates the stator flux components in the stationary reference frame, using the derivatives of the stator flux components as mathematical model and the stator voltage equations as observation model. The experiments show a comparison between DE and genetic algorithms (GAs) with different settings. The DE outperformed the best known GAs on proposed optimization problem. The paper concentrates on a low-speed training test and the experiments show the low-speed performance of the sensorless control scheme using the new optimized DSKF-based algorithm.
Adapting TRIBES algorithm for Traveling Salesman Problem

Metaheuristics constitute an important alternative in solving NP-Hard combinatorial optimization problems. Unfortunately, many parameters have to be tuned for any metaheuristic, and their values may have a great influence on the efficiency and effectiveness of the search. The exploration of an optimal combination of such values may be difficult and big time consuming. Clerc et al have defined a parameter-free algorithm for PSO (Particle Swarm Optimization), called TRIBES. In this paper, we propose to adapt TRIBES to solve discrete problems. To highlight our approach, we treat of the well-known NP-Hard Traveling Salesman Problem (TSP) problem. Modifications in different mechanisms and formulae adaptations are made, like in the generation process of the particles and in the displacement strategies. The experimentations results show the good behavior of the “Adapted TRIBES”. Comparison is made with a basic genetic algorithm, and with a branch and bound method.
Médecine 3.0 en médecine générale : où en sommes-nous en Normandie en 2016 ? Quelle place, quelles limites ?

Une nouvelle ere, la medecine 3.0 s'annonce avec l'utilisation d'outils permettant aux medecins d'etre encore plus performants ainsi que d'apporter une meilleure qualite de soins a leurs patients. Nous avons realise une etude sur les pratiques de la sante connectee des medecins generalistes normands en 2016, une photographie de leur activite technologique. Methode : Nous avons realise une etude transversale, observationnelle et descriptive a partir d'un questionnaire de 14 questions transmis aux medecins generalistes normands avec l'aide de l'interface de surveymonkey. Resultats: 191 reponses de medecins generalistes ont pu etre exploitees, 37% avaient moins de 40 ans. 9% soit 17 participants disposaient d'un appareil connecte ; a la question de l'interet, 40% y voyaient un interet moyen dans un futur proche, 48% y voyaient un interet croissant. 17% des participants avaient deja conseille un objet connecte en sante (OCS) dans leur pratique quotidienne. Les medecins generalistes reconnaissent a 85% que leur niveau de connaissance sur le sujet est faible. Discussion : La medecine 3.0 est encore peu developpee en Normandie en 2016 mais il ressort de cette etude que les medecins generalistes lui portent un interet certain et qu'ils veulent etre acteurs de ce nouveau marche. Pour cela, il va falloir enrichir leur formation et assurer une securite d'usage a tous ces OCS. Il va egalement falloir enrichir la litterature sur le sujet, encore trop peu traite et s'assurer de la securite a la fois de ces outils modernes mais surtout de leurs donnees, sujet hautement sensible qui doit etre sous haute securite.
Asymptotics of the error probability in quasi-static binary symmetric channels

This paper provides an asymptotic expansion of the error probability, as the codeword length n goes to infinity, in quasi-static binary symmetric channels. After the leading term, namely the outage probability, the next two terms are found to be proportional to and respectively. Explicit characterizations of the respective coefficients are given. The resulting expansion gives an approximation to the random-coding union bound, accurate even at small codeword lengths.
Matrix metalloproteinases in inflammatory demyelination

Article abstract Matrix metalloproteinases (MMPs) degrade all protein components of the extracellular matrix. Functionally, they contribute to several different physiologic conditions, such as angiogenesis or bone remodeling, as well as pathologic conditions in humans, such as rheumatoid arthritis and tumor growth. MMPs seem to be important in the pathogenesis of inflammatory demyelinating diseases of the central and peripheral nervous system, especially in MS and in Guillain–Barré syndrome (GBS). Key mechanisms in the genesis of inflammatory demyelination, such as leukocyte recruitment, blood–brain barrier or blood–nerve barrier breakdown, myelin destruction, and release of disease-promoting cytokines, are considered to be MMP-dependent processes. In experimental autoimmune encephalomyelitis, an animal model of MS, and experimental autoimmune neuritis, an animal model of GBS, different synthetic inhibitors targeting MMP activity are able to suppress and even reverse ongoing disease. This evidence points to MMPs as new targets for treatment in inflammatory demyelination.
Association of Pioneer Accountable Care Organizations vs traditional Medicare fee for service with spending, utilization, and patient experience.

IMPORTANCE The Pioneer Accountable Care Organization (ACO) Model aims to drive health care organizations to reduce expenditures while improving quality for fee-for-service (FFS) Medicare beneficiaries. OBJECTIVE To determine whether FFS beneficiaries aligned with Pioneer ACOs had smaller increases in spending and utilization than other FFS beneficiaries while retaining similar levels of care satisfaction in the first 2 years of the Pioneer ACO Model. DESIGN, SETTING, AND PARTICIPANTS Participants were FFS Medicare beneficiaries aligned with 32 ACOs (n = 675,712 in 2012; n = 806,258 in 2013) and a comparison group of alignment-eligible beneficiaries in the same markets (n = 13,203,694 in 2012; n = 12,134,154 in 2013). Analyses comprised difference-in-differences multivariable regression with Oaxaca-Blinder reweighting to model expenditure and utilization outcomes over a 2-year performance period (2012-2013) and 2-year baseline period (2010-2011) as well as adjusted analyses of Consumer Assessment of Healthcare Providers & Systems (CAHPS) survey responses among random samples of beneficiaries in Pioneer ACOs (n = 13,097), FFS (n = 116,255), or Medicare Advantage (n = 203,736) for 2012 care. EXPOSURES Beneficiary alignment with a Pioneer ACO in 2012 or 2013. MAIN OUTCOMES AND MEASURES Medicare spending, utilization, and CAHPS domain scores. RESULTS Total spending for beneficiaries aligned with Pioneer ACOs in 2012 or 2013 increased from baseline to a lesser degree relative to comparison populations. Differential changes in spending were approximately -$35.62 (95% CI, -$40.12 to -$31.12) per-beneficiary-per-month (PBPM) in 2012 and -$11.18 (95% CI, -$15.84 to -$6.51) PBPM in 2013, which amounted to aggregate reductions in increases of approximately -$280 (95% CI, -$315 to -$244) million in 2012 and -$105 (95% CI, -$148 to -$61) million in 2013. Inpatient spending showed the largest differential change of any spending category (-$14.40 [95% CI, -$17.31 to -$11.49] PBPM in 2012; -$6.46 [95% CI, -$9.26 to -$3.66] PBPM in 2013). Changes in utilization of physician services, emergency department, and postacute care followed a similar pattern. Compared with other Medicare beneficiaries, ACO-aligned beneficiaries reported higher mean scores for timely care (77.2 [ACO] vs 71.2 [FFS] vs 72.7 [MA]) and for clinician communication (91.9 [ACO] vs 88.3 [FFS] vs 88.7 [MA]). CONCLUSIONS AND RELEVANCE In the first 2 years of the Pioneer ACO Model, beneficiaries aligned with Pioneer ACOs, as compared with general Medicare FFS beneficiaries, exhibited smaller increases in total Medicare expenditures and differential reductions in utilization of different health services, with little difference in patient experience.
Characterization of Surface-Breaking Cracks Using One Tangential Component of Magnetic Leakage Field Measurements

We propose a procedure for full characterization of rectangular surface-breaking cracks based on measurements of only one tangential component of the magnetic field with the magnetic flux leakage (MFL) technique. The parameters of interest include orientation, length, and depth of the cracks. We assume that the length and the depth of the investigated cracks are much larger than the crack width, so that the variation of the MFL response with respect to the width is negligible. Our procedure employs fast direct methods that provide reliable estimation of the crack parameters in three separate consecutive steps. We propose denoising and correction techniques as well. We confirmed the accuracy of the methods by simulations based on the finite-element method (FEM) as well as by experimental MFL observations. A procedure is proposed for full characterization of rectangular surface breaking cracks based on measurements of only one tangential component of the magnetic field with the magnetic flux leakage (MFL) technique. The parameters of interest include orientation, length and depth of the cracks. We assume that the length and the depth of the investigated cracks are much larger than the crack width such that the variation of the MFL response with respect to the width is negligible. The proposed procedure employs fast direct methods which provide reliable estimation of the crack parameters in three separate consecutive steps. De-noising and correction techniques are proposed as well. The accuracy of the proposed estimation methods is examined via simulations based on the finite element method (FEM) as well as experimental MFL data.
An in vitro study to characterize a new automated high throughput neuronal stretch injury system

AN IN VITRO STUDY TO CHARACTERIZE A NEW AUTOMATED HIGH THROUGHPUT NEURONAL STRETCH INJURY SYSTEM by Nicolae Valerian Hususan Traumatic brain injury (TBI) is one of the most prevalent long-term neurological conditions and its overall economic consequences rival that of stroke. Considering the importance of the topic, new models for studying TBI are often designed and created. Based on a model developed by the University of Pennsylvania, NJIT constructed a fully automated version, which injures neuronal cell cultures in uniaxial regime and provides the high experimental yield required in pharmaceutical and neuroscience studies. In this investigation, a new methodology for culturing primary cortical neurons of rat origin was established. Viable cell cultures developed for the first time in NJIT laboratory were successfully injured using the new NJIT device. The data recorded here may allow us to understand better the complex aspects of head trauma mechanisms and to develop potential therapeutic agents. AN IN VITRO STUDY TO CHARACTERIZE A NEW AUTOMATED HIGH THROUGHPUT NEURONAL STRETCH INJURY SYSTEM by Nicolae Valerian Hususan A Thesis Submitted to the Faculty of New Jersey Institute of Technology in Partial Fulfillment of the Requirements for the Degree of Master of Science in Biomedical Engineering Department of Biomedical Engineering
The break-off phenomenon: a feeling of separation from the earth experienced by pilots at high altitude.

I T is no cause for wonder that aviators have unique subjective experiences. Moreover, it is to be expected that these experiences will change with the changing character of aviation and with differing circumstances attending flight. T o keep abreast of the changing pattern of the aviator's experiences, periodic surveys are necessary. During the course of a recent inquiry, we heard pilots refer to an event in their experience by the term "break-off. " This was defined as a feeling of physical separation from the earth when piloting an aircraft at high altitude. Systematic inqt~iry disclosed that this phenomenon is of sufficient importance to deserve investigation, a n d what follow$ wiilmarizes our findings.