Miracle-dz/UniFAR-FTUs huggingface dataset:
3 DMADMAC | AUTOMATED : synergistic hardware and software solution for automated 3 D digitization of cultural heritage objects

In this article a fully automated 3D shape measurement system and data processing algorithms are presented. Main purpose of this system is to automatically (without any user intervention) and rapidly (at least ten times faster than manual measurement) digitize whole object’s surface with some limitations to its properties: maximum measurement volume is described as a cylinder with 2,8m height and 0,6m radius, maximum object's weight is 2 tons. Measurement head is automatically calibrated by the system for chosen working volume (from 120mm x 80mm x 60mm and ends up to 1,2m x 0,8m x 0,6m). Positioning of measurement head in relation to measured object is realized by computer-controlled manipulator. The system is equipped with two independent collision detection modules to prevent damaging measured object with moving sensor’s head. Measurement process is divided into three steps. First step is used for locating any part of object’s surface in assumed measurement volume. Second step is related to calculation of "next best view" position of measurement head on the base of existing 3D scans. Finally small holes in measured 3D surface are detected and measured. All 3D data processing (filtering, ICP based fitting and final views integration) is performed automatically. Final 3D model is created on the base of user specified parameters like accuracy of surface representation and/or density of surface sampling. In the last section of the paper, exemplary measurement result of two objects: biscuit (from the collection of Museum Palace at Wilanów) and Roman votive altar (Lower Moesia, II-III AD) are presented.
H∞ filtering for a class of singular stochastic time-delay systems

This paper is concerned with the H∞ filtering problem for a class of singular stochastic time-delay systems. The purpose is the design of a delay-independent filter such that the resulting error system is regular, impulse-free and mean-square stable. Sufficient conditions for solvability of this problem are formulated in terms of a set of linear matrix inequalities (LMIs), and stability theory of stochastic differential equations. Based on these conditions, the delay-independent filter can be constructed. Finally, a simulation example is given to illustrate the effectiveness of the theoretical results.
Puri¢cation and characterization of acidic endo-polygalacturonase encoded by the PGL1-1 gene from Saccharomyces cerevisiae

The PGL1 gene of the yeast Saccharomyces cerevisiae has been shown to encode polygalacturonase. Cloning of the PGL1 open reading frame behind the ADH1 promoter allowed overexpression of polygalacturonase activity in S. cerevisiae . This enzyme was purified to apparent homogeneity from cultures of recombinant S. cerevisiae on synthetic medium using one-step purification by anionic exchange chromatography. The enzyme, named Pgl1P, had an apparent M r of 42 kDa as shown by SDS-PAGE. Pgl1P was active from pH 3 to 5.5, with an optimum temperature at 25‡C. This enzyme hydrolyzed polygalacturonic acid as an endo-polygalacturonase as demonstrated by independent methods. The purified protein was N -glycosylated. However, the activity remained in the N -deglycosylated form. The N-terminal amino acid sequence was also determined as D-S-C-T-L-T-G-S-S-L. (cid:223) 2000 Federation of European Microbiological Societies.
The Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial: Rationale and Design

A number of major clinical trials have demonstrated the clinical benefits of lowering blood pressure and have indicated that a majority of patients with hypertension will require more than one drug to achieve optimal blood pressure control. However, there is little data showing which antihypertensive combination best protects patients from cardiovascular events and which best achieves the target blood pressure with the fewest adverse events. The Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) trial is the first large-scale investigator-initiated multicenter study with a prospective, randomized, open, blinded endpoint evaluation (PROBE) design to directly compare cardiovascular mortality and morbidity, incidence of adverse drug reaction, and degree of blood pressure reduction in Japanese hypertensive patients for a combination of angiotensin receptor blockers, β-blockers or thiazide diuretics in addition to a calcium antagonist, benidipine hydrochloride, with a response-dependent dose titration scheme. The COPE trial is being conducted with the cooperation of more than 100 centers and clinics in Japan and involves 3,000 patients, who will be followed for 3 years. Eligible patients are being enrolled from May 2003 until May 2006. Results from the COPE trial should provide new evidence for selecting optimal combination therapies for hypertensive patients.
Converter topologies for permanent magnetic synchronous generator on wind energy conversion system

This paper presents a review of wind energy conversion topologies applicable to permanent magnetic synchronous generator. The use of wind energy as a promissing renewable energy in actual world conjuncture and its use on distributed generation is summarized; a comparison between the main generators used in wind energy production related to the advantages of each one is shown. The paper mainly discusses converter topologies in use with permanent magnetic synchronous generator, focusing on the advantages and control techniques applied.
Amelioration of immobilization stress-induced biochemical and behavioral alterations and mitochondrial dysfunction by naringin in mice: possible mechanism of nitric oxide modulation.

OBJECTIVE The present study was undertaken to evaluate the effects of naringin on immobilization stress-induced biochemical-behavioral changes and mitochondrial dysfunction in mice. METHODS Mice were randomized and grouped based on body weights. Respective drug treatments were given for 14 d, and on the 15th day all the animals were subjected to a 6-hour immobilization stress; then all the animals were subjected to various behavioral paradigms and were sacrificed. Various biochemical parameters and mitochondrial functions were analyzed using brain homogenate. RESULTS The 6-hour acute immobilization stress significantly altered the behavioral (anxiety and memory) and biochemical parameters coupled with mitochondrial dysfunction in mice. Fourteen days pretreatment with naringin (50 and 100 mg/kg, per oral) significantly inhibited the behavioral and biochemical alterations and mitochondrial dysfunction caused by acute immobilization stress (P<0.05). Further, pretreatment with L-arginine (50 mg/kg, intraperitoneally), a nitric oxide precursor, reversed the protective effect of naringin (P<0.05). In addition, pretreatment with NG-nitro-L-arginine methyl ester (5 mg/kg, intraperitoneally) caused potentiation in the protective effect of naringin. CONCLUSION These results suggest the possible involvement of nitrergic pathway in the protective effect of naringin against immobilization stress-induced behavioral, biochemical and mitochondrial dysfunctions in mice.
Development of arthrogenic joint contracture as a result of pathological changes in remobilized rat knees

This study aimed to elucidate how rats recover from immobilization‐induced knee joint contracture. Rats’ right knees were immobilized by an external fixator at a flexion of 140° for 3 weeks. After removal of the fixator, the joints were allowed to move freely (remobilization) for 0, 1, 3, 7, or 14 days (n = 5 each). To distinguish myogenic and arthrogenic contractures, the passive extension range of motion was measured before and after myotomy of the knee flexors. Knee joints were histologically analyzed and the expression of genes encoding inflammatory or fibrosis‐related mediators, interleukin‐1β (1L‐1β), fibrosis‐related transforming growth factor‐β1 (TGF‐β1), and collagen type I (COL1A1) and III (COL3A1), were examined in the knee joint posterior capsules using real‐time PCR. Both myogenic and arthrogenic contractures were established within 3 weeks of immobilization. During remobilization, the myogenic contracture decreased over time. In contrast, the arthrogenic contracture developed further during the remobilization period. On day 1 of remobilization, inflammatory changes characterized by edema, inflammatory cell infiltration, and upregulation of IL‐1β gene started in the knee joint posterior capsule. In addition, collagen deposition accompanied by fibroblast proliferation, with upregulation of TGF‐β1, COL1A1, and COL3A1 genes, appeared in the joint capsule between days 7 and 14. These results suggest the progression of arthrogenic contracture following remobilization, which is characterized by fibrosis development, is possibly triggered by inflammation in the joint capsule. It is therefore necessary to focus on developing new treatment strategies for immobilization‐induced joint contracture. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1414–1423, 2017.
An Analysis of Complexity Metrics for Website

With increasing contents and features, it is clear that the growth of the World Wide Web has brought benefits for individuals and organisations. For website users, they would be benefited by the frequently updated information as well as an available purchasing channel, while for companies, websites become the tool for building effective communication with users, gaining profit and increasing their awareness. However, it may also cause some issues with the use of websites, such as lower loading speed. Since the website complexity is depended on the web design concept, while as one of the crucial components of website design, the colour would play an important role, the similar concept could also be raised as the colour complexity, referring to the richness of colour used during website design. Research finding as presented in this paper will be help to understand the influence of colour complexity and could be used to support the research on website complexity.
Wnt Signaling and Epithelial-Mesenchymal Transition Network in Cancer

Wnt signaling is involved in the development of cancer malignancy. Epithelial-mesenchymal transition (EMT) is a phenomenon in which the epithelial-like cellular phenotype changes into the mesenchymal-like cellular phenotype. The recent advances in the research have revealed that some population of cancer stem cells (CSCs) exhibit the EMT-like feature, however, the whole picture of the molecular signature of CSCs and EMT are not fully revealed. In this Editorial, the present insights in the relationship between Wnt signaling and EMT in cancer have been summarized. It is important to reveal the molecular signatures and networks of EMT and CSCs with regard to Wnt signaling pathway.
GWASdb v 2 : an update database for human genetic variants identified by genome-wide association studies

Genome-wide association studies (GWASs), now as a routine approach to study single-nucleotide polymorphism (SNP)-trait association, have uncovered over ten thousand significant trait/disease associated SNPs (TASs). Here, we updated GWASdb (GWASdb v2, http://jjwanglab.org/gwasdb) which provides comprehensive data curation and knowledge integration for GWAS TASs. These updates include: (i) Up to August 2015, we collected 2479 unique publications from PubMed and other resources; (ii) We further curated moderate SNP-trait associations (P-value < 1.0×10−3) from each original publication, and generated a total of 252 530 unique TASs in all GWASdb v2 collected studies; (iii) We manually mapped 1610 GWAS traits to 501 Human Phenotype Ontology (HPO) terms, 435 Disease Ontology (DO) terms and 228 Disease Ontology Lite (DOLite) terms. For each ontology term, we also predicted the putative causal genes; (iv) We curated the detailed sub-populations and related sample size for each study; (v) Importantly, we performed extensive function annotation for each TAS by incorporating gene-based information, ENCODE ChIP-seq assays, eQTL, population haplotype, functional prediction across multiple biological domains, evolutionary signals and disease-related annotation; (vi) Additionally, we compiled a SNP-drug response association dataset for 650 pharmacogenetic studies involving 257 drugs in this update; (vii) Last, we improved the user interface of website.
Inferior long‐term outcomes of liver‐kidney transplantation using donation after cardiac death donors: Single‐center and organ procurement and transplantation network analyses

Limited data are available for outcomes of simultaneous liver‐kidney (SLK) transplantation using donation after cardiac death (DCD) donors. The outcomes of 12 DCD‐SLK transplants and 54 SLK transplants using donation after brain death (DBD) donors were retrospectively compared. The baseline demographics were similar for the DCD‐SLK and DBD‐SLK groups except for the higher liver donor risk index for the DCD‐SLK group (1.8 ± 0.4 versus 1.3 ± 0.4, P = 0.001). The rates of surgical complications and graft rejections within 1 year were comparable for the DCD‐SLK and DBD‐SLK groups. Delayed renal graft function was twice as common in the DCD‐SLK group. At 1 year, the serum creatinine levels and the iothalamate glomerular filtration rates were similar for the groups. The patient, liver graft, and kidney graft survival rates at 1 year were comparable for the groups (83.3%, 75.0%, and 82.5% for the DCD‐SLK group and 92.4%, 92.4%, and 92.6% for the DBD‐SLK group, P = 0.3 for all). The DCD‐SLK group had worse patient, liver graft, and kidney graft survival at 3 years (62.5%, 62.5%, and 58.9% versus 90.5%, 90.5%, and 90.6%, P = 0.03 for all) and at 5 years (62.5%, 62.5%, and 58.9% versus 87.4%, 87.4%, and 87.7%, P < 0.05 for all). An analysis of the Organ Procurement and Transplantation Network database showed inferior 1‐ and 5‐year patient and graft survival rates for DCD‐SLK patients versus DBD‐SLK patients. In conclusion, despite comparable rates of surgical and medical complications and comparable kidney function at 1 year, DCD‐SLK transplantation was associated with inferior long‐term survival in comparison with DBD‐SLK transplantation. Liver Transpl 20:728‐735, 2014. © 2014 AASLD.
GAUSSIAN MIXTURE MODEL-BASED RANDOM SEARCH FOR CONTINUOUS OPTIMIZATION VIA SIMULATION

This paper studies integrated random search algorithms for continuous optimization-via-simulation (COvS) problems. We first tailor the Gaussian process-based search (GPS) algorithm to handle COvS problems. We then analyze the potential sampling issue of the GPS algorithm and propose to construct a desirable Gaussian mixture model (GMM) which is amenable for efficient sampling and at the same time also maintains the desirable property of exploitation and exploration trade-off. Then, we propose a Gaussian mixture model-based random search (GMRS) algorithm. We build global convergence of both the tailored GPS algorithm and the GMRS algorithm for COvS problems. Finally, we carry out some numerical studies to illustrate the performance of the GMRS algorithm.
E-commerce adoption in SME retail sector: A conceptual model

In the past decades, studies on e-commerce adoption by small businesses have attracted a significant attention and mainly focused on manufacturing, distribution and service sector. E-commerce technology adoption in SMEs and their online presence has added more advantages for step forward. Studies also have done in SMEs retail sector realigning its significance to the economy. Different studies have used different models and theories for E-commerce adoption. This paper attempts to discuss a conceptual model with several influencing factors called technological, organizational and environmental and sub factors to achieve a better understanding on e-commerce adoption procedure. The proposed model is adapted from Tornatzky and Fleischer 1990, framework and explained effective way of e-commerce adoption. SME retail sector is the main focused issue in this study.
An experim ental Noise Radar System

Synopsis: The results of experiments with a noise radar, performed in 1964, are given. Attention has been focussed on a flexible crosssection of a possible complete system. As a consequence of this we were able to check the system performance in a straightforward manner with relatively simple hardware. Several features of the sys­ tem have been shown, viz.: the antenna system can be used as a space filter; there is an option for azimuth measurement by mechanical or frequency-scanning. A discussion will be given of the advantages and disadvantages of such a system.
The periaqueductal grey modulates sensory input to the cerebellum: a role in coping behaviour?

The paths that link the periaqueductal grey (PAG) to hindbrain motor circuits underlying changes in behavioural responsiveness to external stimuli are unknown. A major candidate structure for mediating these effects is the cerebellum. The present experiments test this directly by monitoring changes in size of cerebellar responses evoked by peripheral stimuli following activation of the PAG. In 22 anaesthetized adult Wistar rats, climbing fibre field potentials were recorded from the C1 zone in the paramedian lobule and the copula pyramidis of the cerebellar cortex evoked, respectively, by electrical stimulation of the ipsilateral fore‐ and hindlimb. An initial and a late response were attributable to activation of Aβ and Aδ peripheral afferents respectively (hindlimb onset latencies 16.9 and 23.8 ms). Chemical stimulation at physiologically‐identified sites in the ventrolateral PAG (a region known to be associated with hyporeactive immobility) resulted in a significant reduction in size of both the Aβ and Aδ evoked field potentials (mean reduction relative to control ± SEM, 59 ± 7.5 and 66 ± 11.9% respectively). Responses evoked by electrical stimulation of the dorsal or ventral funiculus of the spinal cord were also reduced by PAG stimulation, suggesting that part of the modulation may occur at supraspinal sites (including at the level of the inferior olive). Overall, the results provide novel evidence of descending control into motor control centres, and provide the basis for future studies into the role of the PAG in regulating motor activity in different behavioural states and in chronic pain.
Evolution of Supergene Families Associated with Insecticide Resistance

The emergence of insecticide resistance in the mosquito poses a serious threat to the efficacy of many malaria control programs. We have searched the Anopheles gambiae genome for members of the three major enzyme families— the carboxylesterases, glutathione transferases, and cytochrome P450s—that are primarily responsible for metabolic resistance to insecticides. A comparative genomic analysis with Drosophila melanogaster reveals that a considerable expansion of these supergene families has occurred in the mosquito. Low gene orthology and little chromosomal synteny paradoxically contrast the easily identified orthologous groups of genes presumably seeded by common ancestors. In A. gambiae, the independent expansion of paralogous genes is mainly a consequence of the formation of clusters among locally duplicated genes. These expansions may reflect the functional diversification of supergene families consistent with major differences in the life history and ecology of these organisms. These data provide a basis for identifying the resistance-associated enzymes within these families. This will enable the resistance status of mosquitoes, flies, and possibly other holometabolous insects to be monitored. The analyses also provide the means for identifying previously unknown molecules involved in fundamental biological processes such as development.
Multimodal neuroimaging investigations of alterations to consciousness

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Role of glutathione-s-transferase and CYP1A1*2A polymorphisms in the therapy outcome of south Indian acute lymphoblastic leukemia patients

Abstract Background: Polymorphisms in the drug-metabolizing enzymes are found to be associated with the inter-individual variation in response to a particular drug. Glutathione S-transferases (GSTs) are involved in the metabolism of several anticancer drugs, including alkylating agents, anthracyclines, and cyclophosphamides. Aim: The present study is aimed to examine the association of GST and CYP1A1FNx012A polymorphisms in the susceptibility to acute lymphoblastic leukemia (ALL) and the prognostic significance. Materials and Methods: A total of 92 immunophenotyped patients and 150 cord blood controls were genotyped by PCR for GSTM1 and GSTT1, RQ-PCR allelic discrimination assay for GSTP1 and PCR-RFLP for CYP1A1FNx012A polymorphism. Results: We have previously reported the significant association of GSTM1 (null) and combined GSTP1 {(Ile/Val)/ (Val/Val)} /GSTM1 (null) genotype with the susceptibility to ALL. No significant association was observed with GSTT1 (P=0.75) and CYP1A1FNx012A (P=0.61 for +/- and P=0.86 for -/- respectively) in the susceptibility to ALL. Survival analysis was performed in 50 of the 92 patients who were followed for three years. Kaplan-Meier survival analysis for three years showed significant lower event-free survival in patients harboring GSTP1 (Ile/Val) and GSTP1 (Val/Val) (P=0.038 and 0.0001, respectively) genotype. Cox regression analysis revealed GSTP1 as an independent prognostic marker with 6-fold higher risk with Val/Val genotype (P=0.003). Conclusions: Our results show that GSTP1 (Ile/Val) polymorphism has a role in the susceptibility to ALL and also influence treatment outcome.
Behavioral Indices of Multisensory Integration: Orientation to Visual Cues is Affected by Auditory Stimuli

Physiological studies have demonstrated that inputs from different sensory modalities converge on, and are integrated by, individual superior colliculus neurons and that this integration is governed by specific spatial rules. The present experiments were an attempt to relate these neural processes to overt behavior by determining if behaviors believed to involve the circuitry of the superior colliculus would show similar multisensory dependencies and be subject to the same rules of integration. The neurophysiological-behavioral parallels proved to be striking. The effectiveness of a stimulus of one modality in eliciting attentive and orientation behaviors was dramatically affected by the presence of a stimulus from another modality in each of the three behavioral paradigms used here. Animals trained to approach a low intensity visual cue had their performance significantly enhanced when a brief, low intensity auditory stimulus was presented at the same location as the visual cue, but their performance was significantly depressed when the auditory stimulus was disparate to it. These effects were independent of the animals' experience with the modifying (i.e. auditory) stimulus and exceeded what might have been predicted statistically based on the animals' performance with each single-modality cue. The multiplicative nature of these multisensory interactions and their dependence on the relative positions and intensities of the two stimuli were all very similar to those observed physiologically for single cells. The few differences that were observed appeared to reflect the fact that understanding integration at the level of the single cell requires reference to the individual cell's multisensory receptive field properties, while at the behavioral level populations of receptive fields must be evaluated. These data illustrate that the rules governing multisensory integration at the level of the single cell also predict responses to these stimuli in the intact behaving organism.