Miracle-dz/UniFAR-FTUs huggingface dataset:
Invasive micropapillary carcinoma of the breast in male patients: A case report

Introduction: Invasive micropapillary carcinoma (IMPC) of the breast is a rare morphologic variant of invasive ductal carcinoma (IDC) and is often associated with poor patient outcomes. Breast cancer is extremely rare in males accounting for approximately 1% of all breast cancers. The most common histologic types include IDC and IMPC. As tumors with IMPC components can be found in other organs, metastatic invasive mammary carcinoma (IMC) should be considered as a differential diagnosis when IMPC is found in the breast. Case Report: We report a case of primary IMPC of the breast with regional axillary metastasis in an African American male in his eighth decade. A modified radical mastectomy was performed. Upon pathological examination the tumor was positive for estrogen and negative for human epidermal growth factor receptor 2 (HER2). The patient has responded well postoperatively with tamoxifen as the sole treatment. Conclusion: Due to the rare nature of the disease and the lack of published literature, additional data is needed to better evaluate the response to treatment and survival in male patients with breast IMPC.
Anthropogenic noise affects female, not male house wren response to change in signaling network

Editor: Leonida Fusani Abstract Vocal signals mediate social relationships, and among networks of territorial animals, information is often shared via broadcast vocalizations. Anthropogenic noise may disrupt communication among individuals within networks, as animals change the way they vocalize in noise. Furthermore, constraints on signal transmission, including frequency masking and distance, may affect information exchange following a disruption in social networks. We tested the hypothesis that signaling interactions within networks of breeding male and female house wrens (Troglodytes aedon) depend on distance, ambient noise, and receiver nesting stage. We used playback experiments to simulate territorial intrusions with and without noise playbacks on the territories of established males and simultaneously recorded the vocal responses of neighbors. To examine whether intrusions impacted interactions between males, we used randomization tests to determine whether treatment, distance, noise, or nesting stage affected vocal coordination between challenged and neighboring males. We also quantified singing patterns to explore whether intrusions on territories of challenged males affected singing by males and females on neighboring territories. Males sang at the lowest rates and were less likely to overlap songs with the challenged male when their partner was laying, compared to males during early and late nesting stages. Noise and distance did not affect vocal coordination or male singing rates. Fewer females sang during the intruder-only treatment compared to the control and intrusions with noise. Added noise in the territories of challenged males may have masked signals, and as a result, females only changed their behavior during the intruder-only treatment. Our results suggest that the fertility of breeding partners may be more important to males than short-term changes on rival male territories. Elevated noise did little to alter male responses to threats within networks. Females appeared to eavesdrop on interactions involving neighboring males, but noise may have prevented detection of their interactions.
Population dynamics of Pulsatilla patens (L.) Mill. in a new locality in Poland

Abstract A new locality of Pulsatilla patens (L.) Mill. in the Wyszków-Jegiel Forest District, in the southern part of Puszcza Biała (ATPOL EC79) is described. This locality is situated on an escarpment, at the edge of Peucedano-Pinetum fresh pine forest with elements of Serratulo-Pinetum mixed pine forest and Potentillo albae-Quercetum steppe oak forest. Good light conditions prevail in the place of plant occurrence. Studies carried out in 2008-2015 showed an increasing trend of P. patens population, though, recently, this population seems to be stable. The number of species accompanying the pasque-flower also increased in this time period. It was found based on the analysis of flora directly neighbouring the clumps of the pasque-flower. During 7 years, the number of taxa increased by 31.5% on plot I and by 25% on plot II. In the years 2011-2013, the pasque-flower was represented both by flowering (1-2) and vegetative individuals. Afterwards, the plant was present only in vegetative stage. The number of its leaves varied in time. The highest number of leaves - 14 per individual - was noted in 2014, and the lowest number (1) - in 2012. The reason for a decline in the number of plant clumps in the site Dalekie and, at the same time, the greatest threat was the excavation of sand from the escarpment. In 2012, this escarpment slid down and several clumps of the pasque-flower were destroyed. Forest management and digging up by wild boars were additional factors limiting the population. To preserve the site of P. patens, measures of active protection should be applied.
Characterization of exotic barley genotypes for adaptation, yield and malt traits

The investigation on characterization of exotic barley genotypes for adaptation, yield and malt traits was carried out at Punjab Agricultural University, Ludhiana for period of two years 2014-15 and 2015-16. In experiment-1, out of 24 exotic hulled barley genotypes, 6 genotypes namely IBYT18 (43.50 q/ha), IBYT5 (42.60q/ha), IBYT7 (37.14q/ha), IBYT20 (36.23q/ha), IBYT21 (36.23q/ha) and IBYT23 (35.32q/ha) were identified for having grain yield at par with check BH946 (39.40q/ha). For malt yield, none of the IBYT genotype performed better than the best check (cv.DWRUB52). High heritability along with high genetic advance percentage was recorded for days to heading, grains per spike, 1000-grain weight, hectoliter weight, friability percentage, bold grains percentage showing additive gene control. Traits like days to maturity, ear length, biological yield, harvest index, starch and β-glucan had high h 2 but low values of genetic advance percentage suggesting the involvement of non additive gene action. Grain yield had high significant positive correlation with1000-grain weight, biological yield, harvest index and friability while it had significant negative correlation with grains per spike, ear length and wort filtration rate. In experiment-2, out of 24 exotic hulless genotypes, 7 high yielding genotypes were identified such as INBYT9 (31.25q/ha), INBYT23 (30.80q/ha), INBYT21 (30.34q/ha), INBYT10 (29.89q/ha), INBYT14 (29.44q/ha), INBYT17 (29.44q/ha), and INBYT 24 (28.98q/ha). In present investigation, highest grain yield achieved by hulless barley was 31.25q/ha whereas highest grain yield achieved by hulled barley line was 43.50q/ha. Hulless barley lines were low yielding than hulled barley lines in environments of PAU, Ludhiana. In experiment-3, genetic diversity analysis based on molecular markers revealed that high genetic diversity was present in this exotic material. Association analysis of 26-yield related markers on hulled and hulless genotypes for yield and its component traits revealed non-significant associations.
Correlation of Fasting Lipid Profile in Patients With Chronic Liver Disease: A Descriptive Cross-Sectional Study in Tertiary Care Hospital

Introduction: Chronic liver disease (CLD) is a term used to describe a wide spectrum of disorders, including idiopathic, infectious, genetic, drug-induced, toxin-induced, and autoimmune disorders. The common consequence of chronic damage to the liver is cirrhosis. Cirrhotic patients are further classified by their severity based on the Child-Pugh scoring system. Currently, Child-Pugh scoring consists of ascites, hepatic encephalopathy (HE), prothrombin time, serum albumin level, and total bilirubin level. Lipid panel in CLD is a great marker in determining the severity of CLD. Method and methodology: It was a descriptive cross-sectional study conducted at a tertiary care hospital. A sample size of 122 was calculated by using a RaoSoft Digital Sample Size Calculator (RaoSoft, Inc., Seattle, WA) in which we used 5% as a margin of error, 95% as confidence interval (CI), 178 as population size, and response distribution as 50%. Non-complicated CLD patients having age in between 15 and 80 years with no cirrhotic complications including HE, spontaneous bacterial peritonitis, hepato-pumonary, or hepato-renal syndrome were included in our study; the rest of the CLD patients were excluded from our study. Results: The mean age of the study population was 47.09 ± 12.30 years with more than half of the patients lying among the age group 25-50 years. The study population included 76% of males (n=93) and 24% of females (n=29), with a mean age of females higher than the males. Diabetes mellitus (58.19%) was the most frequent comorbidity associated with CLD in subjects included in our study. Parameters of lipid panel were decreased exponentially as the severity of CLD increases from Child score A to C. Total cholesterol, low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), high-density lipoprotein (HDL), and triglyceride (TG) level decreased as the severity increases in our study. The mean model for end-stage liver disease (MELD) score increased as per hypothesized as the severity increases from Child score A to Child score C, respectively. Conclusion: Our study concluded that as the severity of CLD increases from Child class A to Child class C, the lipid panel profile decreases exponentially which proved the idea that had been hypothesized at the beginning of our study.
Parking versus Congestion Pricing: Comparative Analysis

This paper through comparative analysis of parking charge and congestion pricing features, aims to highlight their possibilities and identify limitations, and thus to encourage transport policy makers to implement them. Both policies can tackle with negative consequences of traffic, such as pollution, noise, accidents, etc. But they still differ in a way they act on car users. Analysis of this similarities and differences will be main task of this paper. The results of analysis can be useful for better understanding of effects of both policies when selecting measures that can be used by decision makers in solving congestion in cities.
Biomass‐Derived Multilayer‐Structured Microparticles for Accelerated Hemostasis and Bone Repair

It is very desirable to develop advanced sustainable biomedical materials with superior biosafety and bioactivity for clinical applications. Herein, biomass‐derived multilayer‐structured absorbable microparticles (MQxTy) composed of starches and plant polyphenols are readily constructed for the safe and effective treatment of bone defects with intractable bleeding by coating multiple layers of quaternized starch (Q+) and tannic acid onto microporous starch microparticles via facile layer‐by‐layer assembly. MQxTy microparticles exhibit efficient degradability, low cytotoxicity, and good blood compatibility. Among various MQxTy microparticles with distinct Q+/T− double layers, MQ2T2 with outmost polyphenol layer possess the unique properties of platelet adhesion/activation and red blood cell aggregation, resulting in the best hemostatic performance. In a mouse cancellous‐bone‐defect model, MQ2T2 exhibits the favorable hemostatic effect, low inflammation/immune responses, high biodegradability, and promoted bone repair. A proof‐of‐concept study of beagles further confirms the good performance of MQ2T2 in controlling intractable bleeding of bone defects. The present work demonstrates that such biomass‐based multilayer‐structured microparticles are very promising biomedical materials for clinical use.
Producing Stuffed Pate and Potatoes Buriet with Kareish cheese fortified with functional foods

In attempted to producing the stuffed pate and potatoes buriet with kareish cheese fortified with 1% (W/W) oat, talbina, lima bean and sweet lupin. The portion size of control and fortified kareish cheeses added at 15% (W/W). In addition, determination the organoleptic evaluation and calculating of total calories of stuffed pate and potatoes buriet with fortified kareish cheese with functional foods at fresh. Results indicated the differences in the nutritional values that appeared on kareish cheese as a result of fortifying it with functional foods. The more increase in concentration of fortification, the more increase in nutritional values of kareish cheese which appeared in the chemical composition including (moisture, protein, fat, fiber, ash, Mg, K, Fe, Zn) contents. Furthermore, sensory evaluation was carried out and the results presented that pate and potatoes buriet which added to them about 15% of control kareish cheese was the highest acceptance, followed by those added to them kareish cheese fortified with talbina, lima bean, oat and sweet lupin, respectively. Moreover, total calories were calculated for the fresh treatments of kareish cheese which were included in producing pate and potatoes buriet products (Kcals/15gm). it was found that pate and potatoes buriet which added to them about 15% of kareish cheese fortified with sweet lupin were the highest calories, followed by the kareish cheese control, the kareish cheese fortified with talbina, lima bean and oat, respectively.
University of Birmingham Simultaneous diffuse optical and Bioluminescence tomography to account for signal attenuation to improve source localization

: Photonics based pre-clinical imaging is an extensively used technique to allow for the study of biologically relevant activity typically within a small-mouse model. Namely, bioluminescent tomography (BLT) attempts to tomographically reconstruct the 3-dimensional spatial light distribution of luminophores within a small animal given surface light measurements and known underlying optical parameters. Often it is the case where these optical parameters are unknown leading to the use of a ‘best’ guess approach or to direct measurements using either a multi-modal or dedicated system. Using these conventional approaches can lead to both inaccurate results and extending periods of imaging time. This work introduces the development of an algorithm that is used to accurately localize the spatial light distribution from a bioluminescence source within a subject by simultaneously reconstructing both the underlying optical properties and source spatial distribution and intensity from the same set of surface measurements. Through its application in 2- and 3-dimensional, homogeneous and heterogenous numerical models, it is demonstrated that the proposed algorithm is capable of replicating results as compared to ‘gold’ standard where the absolute optical properties are known. Additionally, the algorithm has been applied to experimental data using a tissue mimicking block phantom, recovering a spatial light distribution that has a localization error of ∼ 1.53 mm, which is better than previously published results without the need of assumptions regarding the underlying optical properties or source distribution.
Preliminary screening of phytochemical evaluation selected plant of Pisonia alba

The present study was carried out to analyze the phytochemical profile of leaves of Pisonia alba. The leaves powder was successively extracted with polar, non polar and dipolar solvents like, chloroform, ethanol, ethyl acetate, acetone, benzene phytochemical analysis shows the presence of flavonoids, tannin triterpenoids, saponins, sterols, alkaloids and carbohydrates. The result of the study could be useful for description and foundation of a monograph of the plant. It is preliminary screening for quality analysis. Primary phytochemical evaluations is mainly identify secondary metabolites from plant extracts.
Induced Developmental Toxicity Studies With Mercuric Chloride and Polychlorinated Biphenyls on Danio Rerio (Zebrafish) Embryo

Introduction: Fish population is generally considered very sensitive to all kinds of environmental changes to which it is exposed, as they are exclusively aquatic with an external mode of fertilization. The aim of this study is to highlight the effects of some of the most powerful environmental toxicants such as mercuric chloride (HgCl2) and polychlorinated biphenyls (PCBs), which alter the behavioral response, embryo survival rate, embryo hatching ratio, mortality rate, and heart rates of Danio rerio (zebrafish) embryo during its developmental stages. Materials and Methods: Zebrafish (D. rerio) were exposed to progressive concentrations of HgCl2 and PCBs. The water quality parameters were analyzed, and the acute toxicity test was conducted using eight fish for different concentrations; the results were compared with the control group. In addition, behavioral changes at each concentration were observed for the individual fish. Results and Discussion: The fish were exposed to various concentrations of 5, 10, 20, 30, 40, 50, and 60 μg/L of HgCl2 and PCB for a period of up to 2 weeks. The toxicity was concentration as well as time dependent. Toxicity tests revealed that the larvae of zebrafish were more sensitive to these toxicants as compared to the embryos.
Prognostic effect of systemic inflammation in patients undergoing surgery for hepatocellular carcinoma: comparison of composite ratios and cumulative scores

Background The systemic inflammatory has been suggested to predict the prognosis of cancer patients. There are two kinds of methods for evaluating the systemic inflammatory response, namely, composite ratios and cumulative scores. The aim of our study was to compare the prognostic effect of scores and ratios in patients undergoing surgery for liver cancer. Methods We retrospectively enrolled patients who underwent curative resection for hepatocellular carcinoma (HCC) performed between January 2015 to December 2017 in Fudan University Shanghai Cancer Center (FUSCC). Preoperative lymphocyte, monocyte, neutrophil and platelet counts, and CRP and albumin of liver cancer patients were recorded. The relationships among composite ratios, including the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), and C-reactive protein albumin ratio (CAR); cumulative scores, including the neutrophil-lymphocyte score (NLS), platelet-lymphocyte score (PLS), neutrophil-platelet score (NPS), and modified Glasgow prognostic score (mGPS); clinicopathological characteristics; and overall survival (OS) were explored. Results A total of 595 patients were enrolled. When multivariate analysis was adjusted according to TNM, PLR >150, LMR >2.4, CAR >0.22, NLS =1, PLS =1, NPS =1, and mGPS =1 were significantly associated with postoperative OS, except for NLR. Conclusions Both cumulative scores and composite ratios had prognostic effect independent of TNM stage, in patients with liver cancer. However, cumulative scores, basing on normal reference ranges, are simpler and more stable for clinical use.
Key controls on the hydraulic properties of fault rocks in carbonates

A significant knowledge gap exists when analysing and predicting the hydraulic behaviour of faults within carbonate reservoirs. To improve this, a large database of carbonate fault rock properties has been collected from 42 exposed faults, from seven countries. Faults analysed cut a range of lithofacies, tectonic histories, burial depths and displacements. Porosity and permeability measurements from c. 400 samples have been made, with the goal of identifying key controls on the flow properties of fault rocks in carbonates. Intrinsic and extrinsic factors have been examined, such as host lithofacies, juxtaposition, host porosity and permeability, tectonic regime, displacement, and maximum burial depth, as well as the depth at the time of faulting. The results indicate which factors may have had the most significant influence on fault rock permeability, improving our ability to predict the sealing or baffle behaviour of faults in carbonate reservoirs. Intrinsic factors, such as host porosity, permeability and texture, appear to play the most important role in fault rock development. Extrinsic factors, such as displacement and kinematics, have shown lesser or, in some instances, a negligible control on fault rock development. This conclusion is, however, subject to two research limitations: lack of sufficient data from similar lithofacies at different displacements, and a low number of samples from thrust regimes. Thematic collection: This article is part of the Fault and top seals collection available at: https://www.lyellcollection. org/cc/fault-and-top-seals-2019
URBANIZATION, MULTI-MORBIDITIES AND PREFERENCE FOR HEALTH CARE FACILITY: AN INSIGHT FROM RAJASTHAN, INDIA

India experiences rapid pace of urbanization with increasing elderly population and changing disease profile creating new set of health care demands. The study made a novel attempt by exploring the prevalence of morbidities, multi-morbidities along with preferred healthcare facility substantiated by its reasons among the older adults aged 50+ living in urban Rajasthan based on a primary survey. The higher prevalence of single morbidity compared to multi-morbidity reflects the possibility of future healthcare needs. Poisson regression estimates identified the elderly belonging to the non-SC/ST/OBC group and the non-poor household in the age group of 60+ at higher risk of multi-morbidities. The Government hospitals overall enjoy higher acceptance though the reasons vary from their efficiency to lacuna in other healthcare providers. The study suggests incorporating the factors shaping the preferences to develop a suitable healthcare centre for the elderly and the expansion of government healthcare schemes. Successful ageing can get a boost by adequately addressing their healthcare needs.
Systematic identification of pleiotropic genes from genetic interactions

Modular structures in biological networks are ubiquitous and well-described, yet this organization does not capture the complexity of genes individually influencing many modules. Pleiotropy, the phenomenon of a single genetic locus with multiple phenotypic effects, has previously been measured according to many definitions, which typically count phenotypes associated with genes. We take the perspective that, because genes work in complex and interconnected modules, pleiotropy can be treated as a network-derived characteristic. Here, we use the complete network of yeast genetic interactions (GI) to measure pleiotropy of nearly 2700 essential and nonessential genes. Our method uses frequent item set mining to discover GI modules, annotates them with high-level processes, and uses entropy to measure the functional spread of each gene’s set of containing modules. We classify genes whose modules indicate broad functional influence as having high pleiotropy, while genes with focused functional influence have low pleiotropy. These pleiotropy classes differed in a number of ways: high-pleiotropy genes have comparatively higher expression variance, higher protein abundance, more domains, and higher copy number, while low pleiotropy genes are more likely to be in protein complexes and have many curated phenotypes. We discuss the implications of these results regarding the nature and evolution of pleiotropy.