Miracle-dz/UniFAR-FTUs huggingface dataset:
Paternal and Maternal Harsh Parenting and Chinese Adolescents’ Social Anxiety: The Different Mediating Roles of Attachment Insecurity With Fathers and Mothers

Although negative parenting and attachment insecurity have been demonstrated to place children at risk for social anxiety, the different roles of fathers and mothers in this association need to be further clarified. This study examined the different mediating roles of attachment insecurity with fathers and mothers in the association between harsh parenting and social anxiety among Chinese adolescents. A sample of 395 students in the sixth through eighth grades with their parents was enlisted as participants of this survey from two public middle schools located in Northern China. Parents were required to report on their harsh parenting, and students were asked to report on their social anxiety and perceived attachment insecurity with both parents. The results demonstrated that both paternal harsh parenting and maternal harsh parenting were positively associated with attachment insecurity with both parents. More importantly, we found that attachment insecurity with mothers partially mediated the association between maternal harsh parenting and adolescent social anxiety but completely mediated the relation of paternal harsh parenting to adolescent social anxiety. These results expanded extant understandings on the associations among harsh parenting, attachment insecurity, and child social anxiety by taking the different roles of both parents into consideration.
Treatment of urinary tract infections in the era of antimicrobial resistance and new antimicrobial agents

ABSTRACT Urinary tract infections (UTIs) caused by antibiotic-resistant Gram-negative bacteria are a growing concern due to limited treatment options. Knowledge of the common uropathogens in addition to local susceptibility patterns is essential in determining appropriate empiric antibiotic therapy of UTIs. The recommended first-line empiric antibiotic therapy for acute uncomplicated bacterial cystitis in otherwise healthy adult nonpregnant females is a 5-day course of nitrofurantoin, a 3-g single dose of fosfomycin tromethamine, or a 5-day course of pivmecillinam. High rates of resistance for trimethoprim-sulfamethoxazole and ciprofloxacin preclude their use as empiric treatment of UTIs in several communities, particularly if patients who were recently exposed to them or in patients who are at risk of infections with extended-spectrum β-lactamases (ESBLs)-producing Enterobacteriales. Second-line options include oral cephalosporins such as cephalexin or cefixime, fluoroquinolones and β-lactams, such as amoxicillin-clavulanate. Current treatment options for UTIs due to AmpC- β -lactamase-producing Enterobacteriales include nitrofurantoin, fosfomycin, pivmecillinam, fluoroquinolones, cefepime, piperacillin–tazobactam and carbapenems. Treatment oral options for UTIs due to ESBLs-E coli include nitrofurantoin, fosfomycin, pivmecillinam, amoxicillin-clavulanate, finafloxacin, and sitafloxacin while pivmecillinam, fosfomycin, finafloxacin, and sitafloxacin are treatment oral options for ESBLs- Klebsiella pneumoniae. Parenteral treatment options for UTIs due to ESBLs–producing Enterobacteriales include piperacillin-tazobactam (for ESBL-E coli only), carbapenems including meropenem/vaborbactam, imipenem/cilastatin-relebactam, and sulopenem, ceftazidime-avibactam, ceftolozane-tazobactam, aminoglycosides including plazomicin, cefiderocol, fosfomycin, sitafloxacin, and finafloxacin. Ceftazidime-avibactam, meropenem/vaborbactam, imipenem/cilastatin-relebactam, colistin, fosfomycin, aztreonam and ceftazidime-avibactam, aztreonam and amoxicillin-clavulanate, aminoglycosides including plazomicin, cefiderocol, tigecycline are treatment options for UTIs caused by carbapenem-resistant Enterobacteriales (CRE). Treatment options for UTIs caused by multidrug resistant (MDR)-Pseudomonas spp. include fluoroquinolones, ceftazidime, cefepime, piperacillin-tazobactam, carbapenems including imipenem-cilastatin/relebactam, meropenem, and fosfomycin, ceftolozane-tazobactam, ceftazidime-avibactam, aminoglycosides including plazomicin, aztreonam and ceftazidime-avibactam, cefiderocol, and colistin. It is important to use the new antimicrobials wisely for treatment of UTIs caused by MDR-organisms to avoid resistance development.
Developing Deception Network System with Traceback Honeypot in ICS Network

In industrial control system (ICS) network, communication is often conducted using custom protocols. Methods for analysis and protection from cyber threats that are specific to ICS network need to be discussed in line with each device and system specification. In this research, the honeypot technology, which is already practiced in IT networks, was further improved for ICS networks so that it responds to packets reaching the honeypots and even conducts counter-scan to collect information of the attack method and its sources. It has been already presented that machines infected with some known malware (e.g. Havex RAT) in ICS networks conduct scan activities against certain devices. For this type of attack, interaction honeypot is considered effective in identifying infected devices out of such scans. In the simulation based on Modbus Stager, which affects programmable logic controller (PLC) operation and connected PCs, the suggested interaction honeypot, namely “traceback honeypot system (THS)” successfully collected payload that is actually sent in the attacks by emulating responses to commands on Modbus protocols. Information obtained from THS-based observation can be used for proactive purposes as in separating infected devices from the operating network and restricting access to certain devices to prevent further infection in the ICS network. This paper discusses methods of tracking attack sources using the THS and preventing further infection within the network based on the search result.
Nifedipine versus ritodrine during external cephalic version procedure: a case control study

Abstract Objective Published series regarding interventions for facilitating external cephalic version (ECV) have concluded that parenterally administered beta-stimulant tocolytics, increased ECV success rate and reduced the number of cesarean sections. However, there were insufficient data regarding calcium channel blockers to provide good evidence regarding its efficacy. Given the paucity of literature, we aimed to compare the efficacy of nifedipine to that of ritodrine on ECV success rates. Methods This is a retrospective case control study of prospectively collected data of patients who underwent ECV between January 2012 and December 2013 at Bikur Cholim Medical Center and Hadassah-Hebrew University Medical Center in Jerusalem, Israel. Patient undergoing ECV with tocolysis by ritodrine were compared with those using nifedipine as tocolysis. Patients were matched in a one-to-one ration by parity and placental location. Results Overall, 148 women received ritodrine and 148 women received nifedipine before ECV procedure. Overall success rate was higher among the ritodrine group (82.4 vs. 63.5%, p < .001). Among nulliparous and among parous, success rate was higher in the ritodrine group (78.9 vs. 57.9 and 88.6 vs. 73.5%, p = .001, p = .04, respectively). Vaginal delivery rate was higher among the ritodrine group (86.5 vs. 68.9%, p < .001). Cesarean delivery rate was 31.1% for the nifedipine group versus 13.5% in the ritodrine group (p < .001). Number needed to treat to benefit (NNTb) 5.7 (95% confidence interval 3.7–12.1). Overall, 216 of 296 (72.9%) of ECV were successful. Ritodrine was associated with higher success rates as compared with nifedipine (56.5 vs. 32.5%, p < .001). In a multivariate analysis, ritodrine tocolytic therapy was independently associated higher ECV success rates as compared to nifedipine (OR 4.54, 95% CI 2.38–9.09). Higher amniotic fluid index (OR 1.16, 95% CI 1.05–1.28) and nulliparity (OR 0.16, 95% CI 0.08–0.30) were additional independent predictors of ECV outcome. Conclusion Ritodrine significantly improve the success of ECV compared with nifedipine. Both drugs are shown to be safe.
“I can’t have it; I am a man. A young man!” – men, fibromyalgia and masculinity in a Nordic context

ABSTRACT Purpose: Research shows that gender has a substantial impact on the health behaviour such as expression of physical symptoms like persistent pains and aches. However, there is yet little knowledge about the gendered aspect of pain by men who suffer from typical female diseases like fibromyalgia. The purpose of the study was to elucidate the interplay between illness and gender by exploring life-stories of men who suffer from fibromyalgia. Methods: The data were collected through life-story interviews of eight men suffering from fibromyalgia. A narrative methodology for analysis was applied to explore the storytelling and the linguistic and performative aspects of the life-stories. Results: The masculine identity of the participants was re-negotiated by comparisons to other men and life before symptom onset, and by discussing expectations and beliefs of how men should act in contemporary societies. The transition from experiencing a strong, active and reliable body to experiencing a painful, vulnerable and helpless body was perceived as fundamental. Conclusions: Self-management and rehabilitation of fibromyalgia it is not only about learning to manage the symptoms but also about the struggle to find coherence in life through re-constructing gender identity that is acceptable both for the individual and for the community.
Modeling phaeopigment concentrations in water from a shallow mesotrophic lagoon

Concentrations of phaeopigments (Pha) and chlorophyll a (Chl) were determined in surface waters from a temperate lagoon during six sampling campaigns at high and at low tide. In order to develop models for phaeopigment concentration in water, it was necessary to replace Chl with photosynthetic pigment concentration (Pt = Pha+Chl) as one of the explanatory variables. Under first approximation, food availability and water temperature (T) could be considered as independent variables. The concentrations of Pha were then determined following seasonal change of response curves of the consumer community on T. However, multiple regression models with Pt, T and, eventually, salinity as explanatory variables were better able to depict Pha. All equations, developed with Pt, were also solved using Chl as an input variable. Although part of the performance was lost, such back‐transformed models can be used at low/medium T and moderate to high concentrations of Chl. The developed equations about middle to long‐term variations of Pha could be applied to study the biogeochemistry of contaminants related to Pha and to evaluate the dependence on temperature of phytoplankton utilization by consumers.
Sleep apnoea among Australian Aboriginal and Non- Aboriginal patients in the Northern Territory of Australia- a comparative study.

Australian Aboriginal and Torres Straight Islanders (ATSI) are noted to have a higher burden of chronic health conditions. However, there is a paucity of data on Obstructive Sleep Apnoea (OSA) in this population. In this retrospective study, we evaluated the clinical and polysomnographic (PSG) characteristics of ATSI and non- ATSI adult patients who underwent diagnostic PSG between 2011 and 2015. There were a total of 3078 patients. Of the total, 403 (13%) were of ATSI origin. Amongst those of ATSI origin, 61% were male and 39% females, while amongst the non-ATSI cohort, 66% were males. The median age was 47.8 years in ATSI and 51.5 years in the non- ATSI cohort. In the combined cohort, body mass index was >30 kg/m2 ( 61%), hypertension (14.4%), diabetes ( 17.8%) and heart disease ( 23.3%). The ATSI patients had higher rates of class III obesity (27 v 15%), hypertension (26 v 14%), cardiac disease (34 v 23%) and diabetes (37 v 17%). Among all the study participants, the PSG confirmed 83.7% of the patients had an apnoea-hypopnea index (AHI) more than 5/hour, mild (AHI 5-15/hour) in (28.4%), moderate (AHI 15-30/hour) in (22.3%), and severe (AHI > 30/hour) in (33.0%). Among the ATSI patients, 46% had severe OSA. The median total AHI value was higher in the ATSI population (25, IQR: 11 - 58) compared to the non-ATSI (17, IQR: 7 - 36), and in rural/remote population (19, IQR: 8 - 42) compared to urban (17, IQR: 7 - 37). This trend was similar for NREM (Non Rapid Eye Movement)-AHI and REM (Rapid Eye Movement) AHI scores, although statistically significant difference was found only with ATSI status. In the combined cohort the probability of (OR= 1.62, 95% CI: 1.32-2.00, p<0.001) of severe OSA was 62% higher in individual with hypertension , however, when stratified by ATSI status, the association was only significant in the non-ATSI population (OR=1.53 95% CI: 1.21 - 1.94, p<0.001). The odds of severe AHI was also significantly associated with heart disease (1.37; 95%CI: 1.14,1.63, p<0.001), diabetes (1.74; 95%CI: 1.43,2.10; p<0.001) and smoking (1.28; 95%CI: 1.09,1.50, p=0.0023) in the overall study cohort. In both ATSI and non- ATSI patients, BMI, neck circumference, sleep efficiency, wake after sleep onset and respiratory arousal index were significantly higher and independently associated with severe AHI.
Assessment of hematologic and corticosterone response in free-living eastern box turtles (Terrapene carolina carolina) at capture and after handling.

Hematology is a common tool for wildlife health assessments. Manual leukocyte counts are required in reptiles, however, disagreement between quantification methods has been observed in some chelonians. This study determined agreement between two methods of leukocyte quantification, eosinophilic leukopet, and blood film white blood cell (WBC) estimates, in free-living eastern box turtles (Terrapene carolina carolina). Simultaneously, we assessed the impact of handling duration on both leukocyte quantity and corticosterone levels. We collected blood at capture (<2 min from disturbance) and again before release 30-150 min later from 92 box turtles at six sites in Illinois and Tennessee. Constant and proportional error was present in the leukopet results for WBC, lymphocytes, and basophils compared to the estimate method. Both methods were in agreement for heterophils, monocytes, and eosinophils. Agreement between the methods was significantly more likely at WBC counts below 23,241/µl. All hematologic parameters were significantly higher at the final blood draw compared to the initial blood draw using both WBC determination methods, except relative eosinophil and basophil counts. Corticosterone levels varied with time, with maximum concentrations reached at 54 min postcapture, followed by a rapid return to baseline levels. Corticosterone level was not significantly associated with any hematologic parameter or sex. This study provides a framework for understanding the effects of animal handling methodology and diagnostic modality when evaluating hematologic health in box turtles.
High-fat overfeeding does not exacerbate rapid changes in forearm glucose and fatty acid balance during immobilization.

CONTEXT Physical inactivity and high-fat overfeeding have been shown to independently induce insulin resistance. OBJECTIVE Establish the contribution of muscle disuse and lipid availability to the development of inactivity-induced insulin resistance. Design, setting, participants, and interventions: Twenty healthy males underwent seven days of forearm cast immobilization combined with a fully-controlled eucaloric (CON, n=10, age 23±2 yr, BMI 23.8±1.0 kg·m-2) or high-fat diet providing 50% excess energy from fat (HFD, n=10, age 23±2 yr, BMI 22.4±0.8 kg·m-2). MAIN OUTCOME MEASURES Prior to casting, and following 2 and 7 days of immobilization, forearm glucose uptake (FGU) and non-esterified fatty acid (NEFA) balance were assessed using the arterialized venous-deep venous (AV-V) forearm balance method following ingestion of a mixed macronutrient drink. RESULTS Seven days of HFD increased body weight by 0.9±0.2 kg (P=0.002), but did not alter fasting, arterialized whole-blood glucose and serum insulin concentrations or the associated HOMA-IR or Matsuda indices. Two and seven days of forearm immobilization led to a 40±7% and 52±7% decrease in FGU, respectively (P<0.001), with no difference between day 2 and 7 and no effect of HFD. Forearm NEFA balance tended to increase following two and seven days of immobilization (P=0.095). CONCLUSIONS forearm immobilization leads to a rapid and substantial decrease in FGU, which is accompanied by an increase in forearm NEFA balance but is not exacerbated by excess dietary fat intake. Altogether, our data suggest that disuse-induced insulin resistance of glucose metabolism is occurs as a physiological adaptation in response to the removal of muscle contraction.
Assessment of fetal right ventricular myocardial performance index changes following intrauterine transfusion

Abstract Introduction Severe fetal anemia may cause cardiac ischemia, reduced contractility, and dysfunction. The purpose of our study is to evaluate right ventricular myocardial performance index (MPI) before and after intrauterine transfusion (IUT) in patients who underwent this procedure because of fetal anemia due to Rh-D alloimmunization. Materials and methods This prospective cohort study was conducted between January 2018 and June 2019 at Kanuni Sultan Suleyman Research and Training Hospital, Istanbul, Turkey. The pregnant women who were applied IUT because of fetal anemia due to Rh-D alloimmunization in our perinatology clinic were included in the study. Fetal right ventricular MPI before and 24 h after IUT were evaluated. Results A total of 28 IUTs were performed in 17 pregnant women during the study period. The isovolumetric contraction time (ICT) and isovolumetric relaxation time (IRT) values measured before IUT, were found to be significantly longer compared to the ICT and IRT values measured after IUT. The MPI values measured after transfusion was found to be higher than before transfusion. Conclusions The fetal right ventricular MPI increases 24 h after IUT. This increase in the right ventricular MPI might be used as a marker for predicting adverse fetal outcomes following IUT.
Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms

Abstract Topoisomerase II (TOP2) resolves topologically entwined duplex DNA. It generates a transient DNA double-strand break intermediate, known as TOP2 cleavage complex (TOP2cc) that contains a covalent link between TOP2 and the 5′-terminus of the incised DNA duplex. Etoposide, a frontline anticancer drug, freezes the intermediate and forms irreversible TOP2ccs. Tyrosyl-DNA phosphodiesterase 2 (TDP2) is thought to repair irreversible TOP2ccs by hydrolyzing the phosphodiester bond between TOP2 and DNA after the proteasomal degradation of trapped TOP2ccs. However, the functional cooperation between TOP2 and proteasome in the repair of trapped TOP2ccs in vivo remains unknown. In this study, we analyze the repair of etoposide-induced TOP2ccs in wild-type and TDP2-deficient (TDP2–/–) TK6 cells in the absence and presence of MG132, a potent proteasome inhibitor. The results suggested that TOP2ccs were repaired by proteasome-dependent and proteasome-independent pathways. Both proteasome-dependent and proteasome-independent pathways were further subdivided into TDP2-dependent and TDP2-independent pathways, indicating that four pathways operate in the repair of TOP2ccs. In cell survival assays, MG132 increased the etoposide sensitivity of TDP2–/– cells, supporting the TDP2-independent and proteasome-dependent pathway among these multiple repair pathways. We also demonstrated that TDP2 released TOP2 from DNA that contained etoposide-induced TOP2cc without proteolytic degradation in vitro. Taken together, the present findings uncover novel proteasome-independent mechanisms for the repair of TOP2ccs.
Retrospective single-centre series of 1300 consecutive cases of outpatient cervical spine surgery: complications, hospital readmissions, and reoperations

Abstract Background: Outpatient surgery is becoming more common and is more cost-effective than inpatient surgery. Nonetheless, many surgeons and health care administrators are still hesitant to accept outpatient surgery for cervical degenerative spinal disease (C-DSD). This study assesses the types and rates of complications, hospital admissions, and reoperations after outpatient surgery of C-DSD. Methods: Complications, hospital admissions within 90 days of surgery, and reoperations within one year of surgery were recorded retrospectively in 1300 outpatients undergoing microsurgical decompression for C-DSD at the Oslofjord Clinic from 2008 to 2017. The surgical procedures performed were anterior cervical decompression and fusion (ACDF) in 1083 patients and posterior cervical foraminotomy in 217 patients. Results: The surgical mortality rate was 0%. Sixteen major complications were recorded in 15/1300 (1.2%) patients. The complications were neurological deterioration in four patients, postoperative hematoma in two, dural lesions with cerebrospinal fluid leakage in one, deep surgical-site infection in one, persistent hoarseness in three, and persistent dysphagia in five. The two potentially life-threatening hematomas were detected within the planned six-hour observation period. Two (0.2%) patients were admitted to hospital within hours of surgery completion with stroke-like signs and symptoms, and four (0.3%) patients were admitted to hospital within 90 days due to surgery-related events. The rate of reoperations for cervical radiculopathy within 12 months was 25/1171 (2%); eight patients’ reoperations were due to inadequate primary decompression, one was due to recurrent disc herniation at the same level and side, and 16 were due to new-onset radiculopathy from an adjacent level or other side. Conclusions: Outpatient microsurgical decompression of the degenerative cervical spine in carefully selected patients appears to be safe and carries a low major complication rate, low hospital admission rate, and low one-year reoperation rate.
Predictive Outcome Validity of General Health Questionnaire (GHQ-28) in Substance Abuse Patients Treated in Therapeutic Communities

Abstract Objective: The use of psychoactive substances has been one of the most important global public health problems over the last few decades. Among the problems associated with substance use, dual diagnosis is one of the most relevant. This study aims to investigate the predictive validity of the GHQ-28 (General Health Questionnaire-28; “probable psychiatric cases”) in relation to poor treatment outcome measured by (a) “early treatment dropout” and (b) “nonclinically relevant improvement at discharge. ” Methods: A longitudinal prospective design was used. A sample of 219 substance use disorder patients, who received treatment in a therapeutic community, was selected. Patients were assessed using the GHQ-28 and the outcome variables were registered. A hierarchical logistic regression model was performed to identify factors independently associated with the outcome measure (“early treatment dropout” and “nonclinically relevant improvement at discharge”). Results: Of the total sample, 79 subjects (36%) were considered “early treatment dropouts” and 56.6% (102) presented a “nonclinically relevant improvement at discharge. ” The two hierarchical logistic regression results show that being classified as a “probable psychiatric case” was significantly and directly associated with “early treatment dropout” and “nonclinically relevant improvement at discharge,” as a poor in-treatment outcome indicator. Conclusions: The results of this study support the notion that the probable psychiatric cases identified by the GHQ-28 scale have a greater probability of “early treatment dropout” and have a greater probability of “nonclinically relevant improvement in discharge” of the therapeutic community. These data indicate that GHQ-28 is a suitable clinical instrument for predicting dropout and treatment effect in residential substance use disorder treatment.