Miracle-dz/UniFAR-FTUs huggingface dataset:
Serotonergic stretch receptors induce plateau properties in a crustacean motor neuron by a dual-conductance mechanism.

1. The mechanisms for induction of bistable plateau potential properties by a set of serotonergic/cholinergic peripheral stretch receptor cells [gastropyloric receptor (GPR) cells] were examined in the crab stomatogastric ganglion (STG) with the use of intracellular recording techniques. 2. GPR cell stimulation evoked nicotinic excitatory postsynaptic potentials (EPSPs) and induced plateau potential capability in the dorsal gastric (DG) motor neuron. The plateau potential could be triggered during a GPR train either by the summating nicotinic EPSPs or by brief intracellular current injection. After pharmacological blockade of nicotinic and muscarinic receptors, a slow depolarization in response to GPR stimulation was revealed. Prolonged plateau potentials could still be evoked after this treatment. Local application of serotonin (5-HT; 10 microM to 1 mM) mimicked the noncholinergic plateau inducing effects of GPR stimulation in the DG motor neuron. 3. The synergistic action of acetylcholine (ACh) and 5-HT was examined by stimulating the GPR cells at different frequencies (1-20 Hz). The plateau induction was present down to 2 Hz. The time to onset for triggering a plateau during a GPR train was determined by the co-released ACh. 4. The 5-HT-evoked slow depolarization persisted in tetrodotoxin (TTX; 0.1-1 microM), and the DG motor neuron could still produce a plateau potential on brief depolarization in the absence of the spike-generating mechanism. 5. In normal TTX-containing saline, the 5-HT-evoked depolarization was accompanied by a weak and variable decrease in apparent input conductance. After substituting one-half of the extracellular sodium with either Trisma-HCl or choline, the decrease in apparent input conductance became more pronounced. This decrease was converted to an increase in apparent input conductance when extracellular Ca2+ was replaced with Mg2+. 6. Under voltage-clamp conditions, local application of 5-HT caused a slow inward current of prolonged duration in DG. The current versus voltage relationship had an inverted U-shape with no apparent reversal potential in the entire voltage range investigated (-90 to -5 mV). The 5-HT-induced changes in input conductance showed a complex voltage dependence, with a conductance decrease from moderately depolarized voltages. 7. Extracellular Cs+ (2-4 mM) caused the DG to hyperpolarize 2-4 mV from rest, whereas lowering extracellular Ca2+ caused it to depolarize 7-15 mV. The combined action of low extracellular Ca2+ and 2-4 mM Cs+ caused an almost complete block of the slow 5-HT-evoked depolarization. (ABSTRACT TRUNCATED AT 400 WORDS)
Australian Banking System Resilience: What Should Be Expected Looking Forward? An International Perspective

This paper reviews Australian banks’ performance from an international perspective, with a focus on changes in capital and liquidity risk. The paper analyses the extent of any vulnerability that might arise from a potential deterioration in the funding markets and discusses whether liquidity rules, such as those being considered by the Basel Committee on Banking Supervision, may help reduce banks’ liquidity risks and improve financial stability.
CHANGES IN VISUAL ACUITY IN PATIENTS WITH WET AGE-RELATED MACULAR DEGENERATION TREATED WITH INTRAVITREAL RANIBIZUMAB IN DAILY CLINICAL PRACTICE: The LUMIERE Study

Purpose: To survey compliance with recommended intravitreal ranibizumab treatment protocols in daily clinical practice in France, with reference to outcomes. Methods: A retrospective, descriptive, observational study in patients with subfoveal wet age-related macular degeneration treated with ranibizumab. All historical data for the study period, including demographic, treatment, and disease details and visual acuity measurements (baseline, Month 3, and Month 12), were recorded retrospectively at least 12 months after the beginning of treatment. Results: In 551 patients followed by 16 ophthalmologists, 12 months of intravitreal ranibizumab treatment induced a mean visual acuity gain of 3.2 ± 14.8 Early Treatment Diabetic Retinopathy Study–equivalent letters. Fewer than 40% of patients received the recommended treatment of initial 3 monthly injections. More than 50% had to wait >8 days between diagnosis and treatment. At Month 3, visual acuity gain was greater in patients who had received recommended induction and in whom treatment was initiated quickly. At Month 12, the induction-related effect had largely disappeared but the time-to-treatment effect persisted. Patients had an average of 5.1 injections (2.6 during induction period). No patients were monitored monthly as stipulated in the guidelines. Conclusion: Although poor compliance with recommendations has been reflected in mediocre outcomes, there is evidence that practice is improving.
Customer Loyalty Management System Development for Auto 4S Dealers Based on Intelligent Mobile Terminal

With brand sales & service model used by Auto 4S dealers being the mainstream of automobile dealing network in China, customer loyalty management and improvement has become the core competiveness of companies in automobile after-sales-market. This paper combines the intelligent mobile terminal which helps improve customer satisfaction and loyalty with cloud service and summarizes the key factors affecting customer satisfaction and loyalty with reference to foreign achievements. An APP of customer loyalty management system for 4S dealers is developed as an intelligent mobile tool M4S (Mobile for Service, or Mobile 4S) for the communication between 4S dealers and their customers.
Positive experiences and quality of life in Ménière's disorder

Abstract The objective of this study was to determine the influence of positive experiences on the quality of life of patients with Ménière's disorder. Its deign comprised a cross-sectional investigation of members of a self-help group, using a questionnaire of positive experiences, an oto-neurological questionnaire, EuroQol, and Ménière's impact rating. The study sample was 542 members of the Finnish Ménière Federation. Results showed that the positive questions explained 21% of the variance of the EuroQol TTO, 31% of the EuroQol VAS measure, and 35% of the Ménière's impact. This compared with 40% of the variance explained by symptomatic complaints. When both the symptoms and positive measures were taken together, there was an increase in the proportion of the variance explained for the VAS (42%) and Ménière's rating (50%), but not for the TTO (42%). A perspective on the disorder was the main positive experience associated with the increased variance explained. Positive experiences have a significant impact on self-rated quality of life. The results suggest that encouraging a positive perspective on the condition, in addition to treating the underlying symptoms, could be useful in rehabilitative management. Sumario El objetivo de este estudio fue determinar la influencia de las experiencias positivas en la calidad de vida de los pacientes con el trastorno de Ménière. Su diseño involucra una investigación transversal de los miembros de un grupo de auto-ayuda, utilizando un cuestionario de experiencias positivas, un cuestionario de oto-neurología, el EuroQoL, y la escala de calificación del impacto del Ménière. La muestra del estudio fue de 542 miembros de la Federación Finlandesa de Ménière. Los resultados mostraron que las preguntas positivas explicaron el 21% de la varianza del EuroQoL TTO, 31% de la medición EuroQoL VAS, y 35% de la escala de impacto de Ménière. Esto se compara con 40% de la varianza explicada por quejas sintomáticas. Cuando se juntaron tanto los síntomas como las medidas positivas, existió una aumento en la proporción de la varianza explicada por el VAS (42%) sobre elescala Ménière (50%), pero no para el TTO (42%). Una perspectiva del trastorno fue la principal experiencia positiva asociada con el aumento de la varianza explicada. Los experiencias positivas tiene un impacto significativo en la calidad de vida auto estimada. Los resultados sugieren que la estimulación de una perspectiva positiva de la condición, además de tratar los síntomas subyacentes, puede ser útil en el manejo rehabilitativo.
Copper and Quaternary Ammonium Cations Exert Synergistic Bactericidal and Antibiofilm Activity against Pseudomonas aeruginosa

ABSTRACT Biofilms are slimy aggregates of microbes that are likely responsible for many chronic infections as well as for contamination of clinical and industrial environments. Pseudomonas aeruginosa is a prevalent hospital pathogen that is well known for its ability to form biofilms that are recalcitrant to many different antimicrobial treatments. We have devised a high-throughput method for testing combinations of antimicrobials for synergistic activity against biofilms, including those formed by P. aeruginosa. This approach was used to look for changes in biofilm susceptibility to various biocides when these agents were combined with metal ions. This process identified that Cu2+ works synergistically with quaternary ammonium compounds (QACs; specifically benzalkonium chloride, cetalkonium chloride, cetylpyridinium chloride, myristalkonium chloride, and Polycide) to kill P. aeruginosa biofilms. In some cases, adding Cu2+ to QACs resulted in a 128-fold decrease in the biofilm minimum bactericidal concentration compared to that for single-agent treatments. In combination, these agents retained broad-spectrum antimicrobial activity that also eradicated biofilms of Escherichia coli, Staphylococcus aureus, Salmonella enterica serovar Cholerasuis, and Pseudomonas fluorescens. To investigate the mechanism of action, isothermal titration calorimetry was used to show that Cu2+ and QACs do not interact in aqueous solutions, suggesting that each agent exerts microbiological toxicity through independent biochemical routes. Additionally, Cu2+ and QACs, both alone and in combination, reduced the activity of nitrate reductases, which are enzymes that are important for normal biofilm growth. Collectively, the results of this study indicate that Cu2+ and QACs are effective combinations of antimicrobials that may be used to kill bacterial biofilms.
Ambulatory activity, body composition, and lower-limb muscle strength in older adults.

PURPOSE It is unclear how the amount of ambulatory activity (AA) participated in by older adults relates to body composition or leg strength. The aim of this study was to describe associations of pedometer-determined AA with body fat and leg muscle parameters in community-dwelling 50- to 79-yr-olds. METHODS A cross-sectional study of 982 randomly recruited subjects was conducted (51% female; mean age = 62 +/- 7 yr). Dual-energy x-ray absorptiometry measured body composition, including total body fat, trunk fat, and leg lean mass. Isometric strength of the quadriceps and hip flexors was measured using a dynamometer. Leg muscle quality was calculated as kilograms of leg strength per kilogram of leg lean mass. Individual AA was recorded over seven d using a pedometer. RESULTS Average AA was 9622 +/- 4004 steps per day. There was no evidence of a threshold model between AA and body fat, leg lean mass, or leg strength. Multivariable regression analyses adjusting for age revealed that AA was negatively associated with total body fat (overall beta = -0.54, P < 0.001; partial R2 = 0.06) and trunk fat mass (overall beta = -0.28, P < 0.001; partial R2 = 0.05). In women only, a significant positive association between AA and both leg strength (beta = 0.71, P = 0.016; partial R2 = 0.01) and leg muscle quality (beta = 0.08, P = 0.001; partial R2 = 0.02) was observed. CONCLUSIONS These results suggest that pedometer-determined AA is a major determinant of body fat in community-dwelling older adults and is also involved in the maintenance of leg strength and muscle quality in older women.
The use of controlled analgesics in a general population (15‐59 years) — the influence of age, gender, morbidity, lifestyle and sociodemographic factors

The use of controlled analgesics (codeine, buprenorphine and pentazocine preparations) was studied through drugs dispensed (prescriptions) over a one‐year period in the municipality of Tromsø, Norway. Drug use was linked to information from the Tromsø Health Survey, a cross‐sectional survey where the population was invited to a health screening. The study sample comprised 9640 women and 9141 men between 15 and 59 years of age.
Echocardiographic predictors of stroke in patients with atrial fibrillation: a prospective study of 1066 patients from 3 clinical trials.

BACKGROUND Clinical features that consistently predict ischemic stroke in patients with nonvalvular atrial fibrillation have been identified, while echocardiographic risk factors are less well defined. OBJECTIVE To determine whether the results of transthoracic echocardiography add independent information to the clinical risk factors for stroke in patients with atrial fibrillation. METHODS Transthoracic echocardiographic findings and clinical features from 1066 patients with atrial fibrillation assigned to placebo or control in 3 randomized trials (Boston Area Anticoagulation Trial for Atrial Fibrillation, Stroke Prevention in Atrial Fibrillation I Study, and Veterans Affairs Prevention in Atrial Fibrillation Study) were correlated with subsequent ischemic stroke by multivariate analysis. RESULTS The mean + SD age of patients was 67 +/- 10 years, 78% were men, 55% had a history of hypertension, 19% had a history of diabetes, 7% had a previous transient ischemic attack or stroke, and 27% had a history of heart failure. During a mean follow-up of 1.6 years, 78 ischemic strokes occurred (annual rate, 4.7%). Moderate to severe left ventricular systolic dysfunction shown via 2-dimensional echocardiography was a strong independent predictor of stroke (relative risk, 2.5; P<.001) in the 1010 patients in whom echocardiographic values for left ventricular function were available. Left atrial diameter by M-mode echocardiography did not predict stroke (relative risk, 1.02/mm; P = .10). Of 163 patients categorized as low risk based on clinical features (annual stroke rate, 0.8%; 95% confidence interval, 0.2%-3.0%), 10 had moderate to severe left ventricular dysfunction shown via 2-dimensional echocardiography and a 9.3% per year risk of stroke (95% confidence interval, 1.3%-66%). Conversely, 728 of the 847 patients at high risk for stroke based on clinical criteria had normal or mildly abnormal left ventricular function; their stroke rate was 4.4% (95% confidence interval, 3.4%-5.8%). CONCLUSIONS Left ventricular systolic dysfunction shown via 2-dimensional transthoracic echocardiography independently predicts risk of stroke in patients with atrial fibrillation. Echocardiography may prove most useful in a small group of patients who have a low risk of stroke according to clinical factors.
Simulation model development and verification for high voltage GaN HEMT in cascode structure

This paper presents the development of a simulation model for high-voltage gallium nitride (GaN) high-electron-mobility transistors (HEMT) in a cascode structure. A method is proposed to accurately extract the device package parasitic inductance, which is of vital importance to better predict the high-frequency switching performance of the device. The simulation model is verified by a double-pulse tester, and the results match well both in terms of device switching waveform and switching energy. Based on the simulation model, an investigation of the package influence on the cascode GaN HEMT is presented, and several critical parasitic inductances are identified and verified. Finally, a detailed loss breakdown is made for a buck converter, including a comparison between hard switching and soft switching. The results indicate that the switching loss is a dominant part of the total loss in hard-switching conditions in MHz high-frequency range and below 8~10A operation current, therefore soft switching is preferred to achieve high-frequency and high-efficiency operation of the high-voltage GaN HEMT.
Brandscapes: contrasting corporate-generated versus consumer-generated media in the creation of brand meaning

Purpose – The purpose of this paper is to add to the growing literature addressing whether, and to what extent, brand meaning is determined by corporate and consumer-generated processes. To do this, the authors compared the expression of brand meaning across three key sources i.e. first, brand strategy (i.e. traditional marketing mix); second, corporate-generated media (i.e. web site); and third, consumer-generated media (Facebook). Design/methodology/approach – To address the research question of this study, the authors conducted an in-depth investigation into consumer co-creation experiences in the context of Facebook brand communities. The authors then interpreted the findings in relation to the brand strategy (i.e. marketing mix) and brand meaning expressed via corporate-generated online media (i.e. corporate web site). The authors achieved this by applying a narrative discourse analysis to textual data. To effectively handle the high quantity of textual data spawned via consumer-generated media (i.e.
Orthogonal Arrays Constructed by Generalized Kronecker Product

In this paper, we propose a new general approach to construct asymmetrical orthogonal arrays, namely generalized Kronecker product. The operation is not usual Kronecker product in the theory of matrices, but it is interesting since the interaction of two columns of asymmetrical orthogonal arrays can be often written out by the generalized Kronecker product. As an application of the method, some new mixed-level orthogonal arrays of run sizes 72 and 96 are constructed.
Sex chromosome elimination, X chromosome inactivation and reactivation in the southern brown bandicoot Isoodon obesulus (Marsupialia: Peramelidae)

Cytogenetic studies have shown that bandicoots (family Peramelidae) eliminate one X chromosome in females and the Y chromosome in males from some somatic tissues at different stages during development. The discovery of a polymorphism for X-linked phosphoglycerate kinase (PGK-1) in a population of Isoodon obesulus from Mount Gambier, South Australia, has allowed us to answer a number of long standing questions relating to the parental source of the eliminated X chromosome, X chromosome inactivation and reactivation in somatic and germ cells of female bandicoots. We have found no evidence of paternal PGK-1 allele expression in a wide range of somatic tissues and cell types from known female heterozygotes. We conclude that paternal X chromosome inactivation occurs in bandicoots as in other marsupial groups and that it is the paternally derived X chromosome that is eliminated from some cell types of females. The absence of PGK-1 paternal activity in somatic cells allowed us to examine the state of X chromosome activity in germ cells. Electrophoresis of germ cells from different aged pouch young heterozygotes showed only maternal allele expression in oogonia whereas an additional paternally derived band was observed in pre-dictyate oocytes. We conclude that reactivation of the inactive X chromosome occurs around the onset of meiosis in female bandicoots. As in other mammals, late replication is a common feature of the Y chromosome in male and the inactive X chromosome in female bandicoots. The basis of sex chromosome loss is still not known; however later timing of DNA synthesis is involved. Our finding that the paternally derived X chromosome is eliminated in females suggests that late DNA replication may provide the imprint for paternal X inactivation and the elimination of sex chromosomes in bandicoots.
Single-Walled Carbon Nanotube-Based Near-Infrared Optical Glucose Sensors toward In Vivo Continuous Glucose Monitoring

This article reviews research efforts on developing single-walled carbon nanotube (SWNT)-based near-infrared (NIR) optical glucose sensors toward long-term in vivo continuous glucose monitoring (CGM). We first discuss the unique optical properties of SWNTs and compare SWNTs with traditional organic and nanoparticle fluorophores regarding in vivo glucose-sensing applications. We then present our development of SWNT-based glucose sensors that use glucose-binding proteins and boronic acids as a high-affinity molecular receptor for glucose and transduce binding events on the receptors to modulate SWNT fluorescence. Finally, we discuss opportunities and challenges in translating the emerging technology of SWNT-based NIR optical glucose sensors into in vivo CGM for practical clinical use.
Practical depression screening in residential care/assisted living: five methods compared with gold standard diagnoses.

OBJECTIVE To test the accuracy of five practical depression screening strategies in older adults residing in residential care/assisted living (RC/AL). DESIGN Cross-sectional screening study. SETTING Four RC/AL communities in North Carolina. PARTICIPANTS A total of 112 residents aged > or =65 and 27 staff members involved in their care. MEASUREMENTS Direct care staff was trained in and completed the Cornell Scale for Depression in Dementia, modified for use by long-term care staff (CSDD-M-LTCS). They additionally responded to a one-item question "Do you believe the resident is often sad or depressed? " and the Minimum Data Set Depression Rating Scale (DRS). Residents responded directly to the Geriatric Depression Scale (15-item version; GDS-15) and the Patient Health Questionnaire, 2-item version (PHQ-2). A geriatric psychiatrist performed gold standard diagnostic interviews using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Sensitivities and specificities were calculated for all instruments at predetermined cutpoints. RESULTS Gold standard diagnoses yielded 14% prevalence of major or minor depression. The CSDD-M-LTCS and one-item screen completed by caregivers failed to significantly discriminate depressed cases. The DRS yielded high specificity (0.85) but low sensitivity (0.47). For the two resident reported measures, the PHQ-2 had a sensitivity of 0.80 and specificity of 0.71, and the GDS-15, 0.60 and 0.75, respectively. CONCLUSION Measures completed by caregivers failed to adequately detect depression. Of the measures completed directly by residents, the PHQ-2 seems to have the best mix of brevity, sensitivity, and ease of administration.
Performance analysis of linear precoding based on field trials results of MIMO-OFDM system

We use field trial results obtained from a multiple-input multiple-output (MIMO) orthogonal frequency-division multiplexing (OFDM) wireless system with two transmitter and three receiver antennas (2/spl times/3), to first validate the properties of the transmit correlation matrix in a macro-cellular environment. We find that approximately 20% of the locations have well-defined transmit correlation matrices. Furthermore, the eigenvectors of the transmit correlation matrix vary slowly over distance with 60% of the locations having eigenvector variation of less than 1 dB over a distance of 20 m. Next, we quantify the performance of the optimal statistical linear precoding (OSLP) , and statistical one-dimensional (1-D) eigenbeamforming (SEB) based on transmit correlation matrices, and the 1-D eigenbeamforming (EB)-based on perfect channel knowledge at the transmitter. We find that the OSLP and SEB schemes obtain array gain over the Alamouti scheme at lower signal-to-noise ratio (SNR) with a median gain of 2.0 (1.5) dB at the 1.0-(3.5) km cell-radii. However, the SEB scheme (unlike the OSLP scheme) looses diversity order at higher SNR that leads to a performance loss. The EB scheme provides the best performance over the Alamouti scheme, at the expense of increased feedback requirements.