Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term efficacy and safety of Pimobendan in moderate heart failure: A double-blind parallel 6-month comparison with enalapril

In view of growing scepticism as to the efficacy and safety of agents with predominant phosphodiesterase inhibiting properties in heart failure, the clinical efficacy and safety of pimobendan, a calcium-sensitizing and partially phosphodiesterase-inhibiting compound, was compared with enalapril in 242 patients with mild to moderate heart failure (NYHA classification II-III) despite diuretics and digitalis, and abnormal haemodynamics at baseline. Patients were randomly assigned to either pimobendan (average 10.3 mg.day-1, n = 119), or enalapril (average 10.7 mg.day-1, n = 123) in a double-blind fashion for 6 months. Forty-two pimobendan and 37 enalapril patients stopped the treatment, five pimobendan and six enalapril due to worsening of failure without death, whereas 13 and eight patients, respectively, died from cardiac disorders (ns). Other reasons for discontinuation and adverse events not leading to discontinuation were also comparable. Although Holter analysis at 14 days, but not at 6 months, indicated increased ventricular extrasystoles in pimobendan patients, these did not lead to serious clinical events. NYHA classification improved similarly in both groups, from 2.51 to 2.16 (pimobendan) and from 2.40 to 2.06 (enalapril). The number of patients needing a change in background therapy or hospitalization did not differ between the two groups. Haemodynamic variables at rest were improved by both compounds after 6 months. In contrast, only enalapril improved haemodynamics during exercise, and reduced the cardiothoracic ratio. The primary endpoint, exercise capacity, increased significantly during the first 3 months by 45 and 53 s, under pimobendan and enalapril, respectively, but, although unchanged thereafter, the improvement was no longer statistically significant at 6 months in either group. (ABSTRACT TRUNCATED AT 250 WORDS)
1-[(E)-(3,4-Dimethylisoxazol-5-yl)iminomethyl]-2-naphthol

The title Schiff base compound, C16H14N2O2, has been synthesized by the reaction of 5-amino-3,4-dimethylisoxazole and 2-hydroxy-1-naphthaldehyde. The dihedral angle between the isoxazole ring and the napthyl ring system is 3.29 (7)°. The molecule adopts an E configuration about the central C=N double bond. Intramolecular O—H⋯N hydrogen bonding generates an S(6) ring motif. In the crystal structure, π–π interactions are observed involving the isoxazole ring and the substituted benzene ring of the naphthyl unit, with centroid–centroid distances of 3.5200 (10) Å.
KEMI-TORNIO UNIVERSITY OF APPLIED SCIENCES Template Management in a Large ERP Environment: Case Study YIT

1.1 Motivation and background . 4 1.2 Research topic and research questions . 9 1.3 Research methods. 10 1.4 The findings of the thesis in brief . 12 1.5 Structure of the thesis . 13 2 THEORETICAL FRAMEWORK . 14 2.1 Enterprise Resource Planning systems. 14 2.1.1 ERP life cycle . 16 2.1.2 Different organizational and national cultures and ERP . 17 2.2 ERP template management . 21 2.3 ERP implementation methods . 24 2.4. ERP post-implementation phase . 26 2.5 The current template management process . 27 2.5. 1 The role of the IT organization in the template management process . 28 2.5. 2 The role of the business process owners in the template management process . 30 3 CASE STUDY ANALYSIS . 32 4 MAIN FINDINGS . 33 5 CONCLUSIONS . 34 REFERENCES . 35 APPENDIX 1 (Confidential) CASE STUDY ANALYSIS APPENDIX 2 (Confidential) MAIN FINDINGS APPENDIX 3 (Confidential) INTERVIEW FORM APPENDIX 4 (Confidential) INTERVIEW TRANSCRIPT APPENDIX 5 (Confidential) INTERVIEW TRANSCRIPT
Atención médica y oftalmológica de una población diabética previo a su ingreso a un centro oftalmológico de referencia

La diabetes mellitus (DM) representa un problema de salud pública en México. El costo anual estimado para el 2005 en gastos relacionados directa (morbilidad) e indirectamente (mortalidad e incapacidad) con DM fue cercano a 317 millones de dólares (1). El gasto anual asignado a DM representó el 12.2% del gasto total del Instituto Nacional de Salud Pública (SSA, IMSS, ISSSTE) (1). Los reportes de población afectada en México varían según los estudios entre Atención médica y oftalmológica de una población diabética previo a su ingreso a un centro oftalmológico de referencia
2-[(Cyclopenta-1,3-dien-2-yl)diphenylmethyl]-1-methyl-1H-imidazole

The title compound, C22H20N2, (Ib), forms along with 2-[(cyclopenta-1,3-dien-1-yl)diphenylmethyl]-1-methyl-1H-imidazole, (Ia), which differs with respect to the position of the double-bonds in the C5H5 ring, in an approximately 3:7 ratio (Ia:Ib; NMR spectroscopy data). However, in a single crystal, only compound (Ib) is present. H atoms of the CH2 group (C5H5 ring) were found from the difference Fourier synthesis and refined isotropically using the riding model. Hypothesis on possible presence of the (Ia) isomer in crystal lattice (model with a C5H5 ring disordered between two positions) was especially checked and rejected due to its inconsistency. In the crystal structure, no significant hydrogen-bonding interactions between the CH2 groups of the C5H5 rings and nonsubstituted N-atoms of the imidazole rings were observed. Despite the fact that the chemically achiral compound (I) crystallizes in a chiral space group P212121, neither the absolute structure determination nor assignment of the inversion twinning was possible in the absence of a heavy atom.
1-(2-Chlorobenzoyl)-3-(2-trifluoromethylphenyl)thiourea

The dihedral angle between the benzene rings in the title compound, C15H10ClF3N2OS, is 54.02 (4)°. An intramolecular N—H⋯O hydrogen bond occurs. In the crystal, N—H⋯S hydrogen bonds link the molecules into inversion dimers.
CT coronary angiography: where does it fit?

In the last 3 y, we have witnessed an impressive injection of new imaging technology for the evaluation of patients with known or suspected coronary artery disease (CAD). Indeed, the introduction of multidetector CT scanners with submillimeter spatial resolution and subsecond gantry rotations made noninvasive imaging of the coronary arteries possible. Therefore, CT angiography (CTA) is without a doubt a powerful noninvasive modality for evaluating and excluding CAD and will likely play an important role in the diagnosis of CAD. There has been much discussion and intense controversy as to whether radiologists or cardiologists should be
2,4-Dioxa-λ6-thiatetracyclo[5.3.1.15,9.01,5]dodecane-3,3-dione

The crystal structure of the title compound, C9H12O4S, was determined in order to investigate the effect of the eclipsed O atoms on the bond length of the vicinal quaternary C atoms. The two quaternary C atoms of the noradamantane skeleton and the two O atoms to which they are connected all located essentially in the same plane (maximum deviation = 0.01 Å), resulting in an eclipsed conformation of the C—O bonds. The C—C bond of the quaternary C atoms is 1.581 (3) Å, considerably longer than the other C—C bonds of the molecule due to the stretch of the cage structure.
Gradual-SURF

In order to improve the high complexity problem of SIFT, SURF algorithm uses the DoH (Determinant of the Hessian) which is simplified and approximate. This improvement not only guarantees the stability of the algorithm, but also increases the calculation efficiency. But when the SURF simplifies the DoH gaussian second order differential template, some of the image gradient information were lost. Therefore, an Gradual SURF(G-SURF) operator is proposed in the this paper, and the gradient information is added in the process. Experimental results show that the proposed improved SURF operator can get a more stable effect, and improve calculation complexity at the same time.
The Use of Problem-Based Learning in Medical Education

Since the introduction of a problem-based learning (PBL) curriculum at the McMaster University School of Medicine in 1969, many medical schools in different regions of the world have adopted this approach, usually with some variations to suit their local needs. The aims of this review are to report some of our experiences at McMaster, to discuss some of the concerns which are associated with the introduction of PBL in a traditional medical school, and to review our recent experience in the introduction of PBL in Physiology in a traditional medical school. Some of the advantages of PBL are: early exposure of students to clinical settings and patients; motivation to learn is self-imposed, because students can see the practical application of the knowledge they are acquiring during their studies; and the acquisition of various learning skills, which will assist them to become lifelong learners. There are also some perceived weaknesses to PBL, which include a lack of traditional structure and progression, and a lack of depth in the knowledge acquired. Teachers with these concerns do not recognize the integrative nature, and you- learn- what- you- need aspect of PBL. Specific evaluative tools have now been developed, which will provide better measures of the learning behaviour, knowledge and clinical skills. Our recent experience in the introduction of PBL in the teaching of Physiology at the University of Hong Kong shows that with appropriate training of the students and teachers, high school students entering first year university are capable of benefiting from the PBL approach. In conclusion, any modification or improvement in the curriculum needs to be based on sound reasoning and upon experimental evidence. We have gained a significant amount of knowledge about the use of PBL in medical education since 1969, but further improvements and refinements are still necessary in order to meet the needs of the students, and that of the society.
1-Acetyl-t-3-ethyl-r-2,c-6-bis(4-methoxyphenyl)piperidin-4-one

In the title compound, C23H27NO4, the piperidine ring adopts a distorted boat conformation. The methoxy groups lie in the plane of benzene rings to which they are attached [maximum deviations of 0.014 (3) and 0.007 (3) Å]. The benzene rings are oriented at angles of 67.2 (1) and 87.0 (1)° with respect to the best plane through the four co-planar atoms of the piperidine ring.
A novel singular node‐based smoothed finite element method (NS‐FEM) for upper bound solutions of fracture problems

It is well known that the lower bound to exact solutions in linear fracture problems can be easily obtained by the displacement compatible finite element method (FEM) together with the singular crack tip elements. It is, however, much more difficult to obtain the upper bound solutions for these problems. This paper aims to formulate a novel singular node‐based smoothed finite element method (NS‐FEM) to obtain the upper bound solutions for fracture problems. In the present singular NS‐FEM, the calculation of the system stiffness matrix is performed using the strain smoothing technique over the smoothing domains (SDs) associated with nodes, which leads to the line integrations using only the shape function values along the boundaries of the SDs. A five‐node singular crack tip element is used within the framework of NS‐FEM to construct singular shape functions via direct point interpolation with proper order of fractional basis. The mix‐mode stress intensity factors are evaluated using the domain forms of the interaction integrals. The upper bound solutions of the present singular NS‐FEM are demonstrated via benchmark examples for a wide range of material combinations and boundary conditions. Copyright © 2010 John Wiley & Sons, Ltd.
Using a mixed design study to develop a breast screening intervention among Chinese women in the UK

Breast cancer is the most common cancer among Chinese women living in the UK. However the literature suggests that Chinese women are less likely to attend breast screening than white British women. No studies have been conducted to explore reasons for low attendance among this specific population. The purpose of this thesis was to understand the psycho-social factors related to breast cancer prevention and screening among Chinese women in the UK, and then to inform a breast screening intervention design. Three studies were conducted. The first was a systematic review of interventions to increase breast screening among Chinese women living in Western countries. The second and third studies used focus groups to explore Chinese women’s beliefs about breast cancer prevention and screening practices among older and younger generations. Finally, Intervention Mapping was used to synthesise the findings of the focus groups with those of the systematic review to design an empirical and theoretical evidence based breast screening intervention directed at Chinese women who are non-adherent to the NHS Breast Screening Programme. The qualitative findings revealed that older participants held a more holistic view of health maintenance, and had less knowledge about breast cancer and its causes than younger participants. They showed positive attitudes to breast screening and most had responded to receiving a mammography invitation. Language was a key barrier to older participants using medical care and obtaining health-related information. Younger participants expressed high dissatisfaction with health care in UK and showed a strong ‘neo-fatalistic’ view of breast cancer prevention, believing the main cause of breast cancer to be genetic predisposition. The synthesis of findings suggest that healthcare providers need to take Chinese cultural and language concerns, but also the differences between generations, into account when designing and implementing breast screening services and educational programmes which target Chinese women.
Improving Zoonotic Disease Outbreak Detection Practice in the United States

of Dissertation.vi List of Figures.ix List of Tables.xii List of Abbreviations.xvi Chapter 1: Introduction.1 Chapter 2: Literature Review . 21 Chapter 3: Methods . 87 Chapter 4: Legal Analysis.151 Chapter 5: Development and Analysis of Outbreak Database.242 Chapter 6: Case Studies . 310 Chapter 7: Policy Recommendations and Conclusions.354 References.390 Appendix A.418 Appendix B.423 Appendix C.449
5-[(E)-(2-Hydroxybenzylidene)amino]-1H-1,3-benzimidazole-2(3H)-thione

There are two molecules in the asymmetric unit of the title compound, C14H11N3OS. In each, the benzimidazole ring system is essentially planar, with maximum deviations of 0.010 (2) and 0.006 (2) Å, and makes dihedral angles of 8.70 (9) and 13.75 (8)°, respectively, with the hydroxy-substituted benzene rings. Each molecule adopts an E configuration about the central C=N double bond. In the crystal, the two independent molecules are connected via intermolecular N—H⋯S hydrogen bonds, forming dimers. Furthermore, the dimers are connected by N—H⋯O hydrogen bonds into molecular ribbons along the c axis. There is an intramolecular O—H⋯N hydrogen bond in each molecule, which generates an S(6) ring motif.
Prevalence of Metabolic Syndrome among Health Care Personnel and Office Workers in Lampang Hospital

Background : Metabolic syndrome (MetS) increases higher risk of cardiovascular disease. Currently the most popular criteria for MetS diagnosis is the International Diabetes Federation (IDF) consensus 2005. Its prevalence has been documented in some studies in Thailand, but mostly did not use IDF criteria. Objective : To estimate the prevalence of MetS in healthcare personnel and office workers in Lampang Hospital. Material and method : The medical records of annual check-up results of Lampang Hospital personnel between October 2008 and September 2009 were retrospectively reviewed. General data, clinical findings and laboratory results were recorded. MetS diagnosis was based on IDF criteria. The data was analyzed by descriptive statistics. Results : Among 1,199 personnel recruited in this study, the mean age was 46.2 ± 6.4 years and 83.1% were female. The prevalence of MetS was 9.5 % (15.3% in male and 8.3% in female). Its prevalence increased with age. Conclusion : The prevalence of MetS in healthcare personnel and office workers in Lampang Hospital was 9.5% and increased with age. Diet control and regular exercise should be encouraged to decrease the risk of cardiovascular disease. Keywords : Metabolic syndrome, Prevalence, Healthcare personnel
PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO GRANDE DO SUL INSTITUTO DE GERIATRIA E GERONTOLOGIA PROGRAMA DE PÓS-GRADUAÇÃO EM GERONTOLOGIA BIOMÉDICA AVALIAÇÃO DA ATIVIDADE DA TELOMERASE EM CÉLULAS-TRONCO DE PACIENTES COM DISPLASIA CORTICAL DE TAYLOR

The Cortical dysplasia is one of the most frequent forms of malformations of cortical development, with a condition that causes a large portion of refractory partial epilepsy to drug treatment. This condition is characterized by a heterogeneous group of cortical lesions and can also be described as cortical dysgenesis or neuronal migration disorder. The genetic factors involved in cortical dysplasia, such as the expression of the telomerase enzyme, are not commonly investigated, mainly due to the limited number of cases is the lack of an experimental model. Objective: This study aimed to analyze the activity and the expression of the enzyme telomerase in patients with cortical dysplasia of Taylor, normal fibroblasts, stem cells from umbilical cord tissue and human tumor. Methodology: the activity and expression of hTERT portion of telomerase were evaluated in patient fibroblasts with Cortical Dysplasia of Taylor (n = 1) and compared with control patients fibroblasts (n = 3) and umbilical cord stem cells (n = 3) and human tumor cell line A549 were maintained in culture. The analysis of the hTERT gene was done by PCR and the telomerase activity was measured by TRAP assay that uses real-time PCR. Results: telomerase activity was higher in tumor cells (Ct = 28.32), while in other cell types and other types studied values were similar: control (Ct = 33.73) Umbilical Cord (Ct = 32.88) and dysplasia (Ct = 33.56). The expression of hTERT portion of telomerase was the control group was 2,58x more expressed, the Dysplasia and tumor groups were 61,25x and 635,48x more expressed respectively as the control. Conclusion: The telomerase appeared to be more active and higher expression in the tumor cell line when compared to other cell types surveyed. The hTERT gene was more expressed in the patient Taylor cortical dysplasia than in the other groups and control umbilical cord indicating that telomerase is expressed in most patients with this disease.
Color-coding

We describe a novel randomized method, the method of color-coding for finding simple paths and cycles of a specified length k, and other small subgraphs, within a given graph G = (V,E). The randomized algorithms obtained using this method can be derandomized using families of perfect hash functions. Using the color-coding method we obtain, in particular, the following new results: • For every fixed k, if a graph G = (V,E) contains a simple cycle of size exactly k, then such a cycle can be found in either O(V ) expected time or O(V ω log V ) worst-case time, where ω < 2.376 is the exponent of matrix multiplication. (Here and in what follows we use V and E instead of |V | and |E| whenever no confusion may arise.) • For every fixed k, if a planar graph G = (V,E) contains a simple cycle of size exactly k, then such a cycle can be found in either O(V ) expected time or O(V log V ) worst-case time. The same algorithm applies, in fact, not only to planar graphs, but to any minor closed family of graphs which is not the family of all graphs. • If a graph G = (V,E) contains a subgraph isomorphic to a bounded tree-width graph H = (VH , EH) where |VH | = O(log V ), then such a copy of H can be found in polynomial time. This was not previously known even if H were just a path of length O(log V ). These results improve upon previous results of many authors. The third result resolves in the affirmative a conjecture of Papadimitriou and Yannakakis that the LOG PATH problem is in P. We can show that it is even in NC.
(1H-Benzimidazol-1-yl)methanol

In the title compound, C8H8N2O, the N—CH2 and CH2—O bond lengths can be correlated to the manifestation of an anomeric effect in the N—CH2—O moiety. In the crystal, intermolecular O—H⋯N hydrogen bonds link the molecules into zigzag chains, with graph-set motif C(6), parallel to [001]. These chains are further linked into sheets by weak nonclassical C—H⋯O hydrogen bonds.
Preeclampsia and maternal type-1 diabetes: new insights into maternal and fetal pathophysiology

Abnormal placentation is associated with preeclampsia and placental insufficiency, both of which increase the risk for fetal growth restriction. So far the early recognition of the risk population for preeclampsia has been problematic. The first hypothesis of this study was that in preeclampsia, the maternal serum proteomic profile is different from that in uncomplicated pregnancies, and this difference is detectable already in early pregnancy. The findings of this study demonstrate that in clinical preeclampsia the maternal serum proteomic profile is different from that in uncomplicated pregnancies with increased levels of placental proteins and antiangiogenic factors in pregnancies with clinical preeclampsia. Furthermore, the early pregnancy maternal serum proteomic profile in women who later develop preeclampsia revealed a distinct and different pattern compared with the profile in clinical preeclampsia. In early pregnancy, the differentially expressed proteins belong to placental proteins, vascular and/or transport proteins and matrix and/or acute phase proteins, while angiogenic and antiangiogenic proteins were not significantly expressed in early pregnancy. Preeclampsia, placental insufficiency, fetal growth restriction and type-1 diabetes may have an impact on fetal cardiovascular hemodynamics. The second hypothesis in this thesis was that in placental insufficiency, abnormalities in fetal cardiovascular status correlate with biochemical markers of cardiac dysfunction and chronic hypoxia. In placental insufficiency, increases in fetal N-terminal pro-atrial (NT-proANP) and pro-B-type natriuretic peptide (NT-proBNP) and in fetal erythropoietin concentrations were related to increased pulsatility in the fetal umbilical artery and descending aorta. In addition, these fetuses demonstrated increased pulsatility in their systemic venous blood velocity waveforms. Thus, in placental insufficiency, biochemical markers of cardiac dysfunction and chronic hypoxia are associated with signs of increased fetal cardiac afterload and systemic venous pressure. Increased NT-proANP and NT-proBNP levels were also detected in fetuses of type-1 diabetic mothers with normal umbilical artery velocimetry. In these pregnancies, NT-proANP and NT-proBNP levels were related to poor maternal glycemic control during early pregnancy.
Management of acute complications of pediatric burns - our experience of 7 years

Material and Methods: This is a retrospective review of children with burns admitted to the Kanchi Kamakoti Childs Trust Hospital, a 220-bed tertiary-care children′s hospital in Chennai, India. Results: Four hundred and twenty-nine children with burns were admitted and treated between 2007 and 2014. Among these, 40 patients with over 20% deep and deep partial thickness burns were transferred to the Pediatric Intensive Care Unit (PICU) for various acute complications. In the presence of invasive sepsis or complication at the time of admission or later, the children are transferred to the PICU. Of the 40 cases transferred, 13 died and 27 survived. Details of the management of these complications and the causes of death were analyzed. It was realized that the survival of 27 burnt children was possible due to the combined team approach of treatment by the burn and plastic surgeons and the intensivists of the PICU. Conclusion: Continued approach is necessary for better survival in pediatric burns.