Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Artificial Sweets on Neurologic Disorders

Background: Sugar- and artificially-sweetened beverage consumption have been connected to cardio metabolic hazard factors, which rise the danger of cerebrovascular illness and dementia. Purpose: We studied whether sugar or artificially sweetened beverage intake was related with the prospective dangers of incident stroke or dementia. Materials and methods: We studied 361 members aged more than 45 years for incident stroke (mean age 61 [SD, 10] years; 163 men) and 185 participants aged >60 years for incident dementia (mean age 68 [SD, 7] years; 85 men). Beverage consumption was computed using a food-frequency questionnaire at cohort studies. We quantified latest consumption at investigation 7 and cumulative intake by averaging across examinations. Surveillance for incident events commenced at examination 7 and continued for 5 years. We observed 12 cases of incident stroke (10 ischemic) and 10 cases of incident dementia (8 consistent with Alzheimer’s disease). Results: After modifications for age, gender, education (for analysis of dementia), caloric consumption, diet feature, physical activity, and smoking, higher recent and higher cumulative consumption of artificially sweetened soft drinks were related with an increased risk of ischemic stroke, all-cause dementia, and Alzheimer’s disease dementia. When comparing day-to-day aggregate consumption to 0 per week (reference), the risk ratios were 2.87 (95% confidence interval, 1.24–6.89) for ischemic stroke and 2.91 (95% confidence interval, 1.15–6.99) for Alzheimer’s disease. Sugar-sweetened beverages were not associated with stroke or dementia. Conclusions: Artificially sweetened soft drink consumption was allied with a higher risk of stroke and dementia.
Business Model Innovation with Platform Canvas

Purpose: This paper offers a literature review and explores a business model innovation for platform business. It also suggests a practical tool, Platform Canvas, to support implementation activities. Design/Methodology/Approach: A literature review was conducted in fall 2016 that resulted in the tentative can-vas approach, which was evaluated in seven real company cases. Findings: The study identified the eight most important characteristics of a platform business model innovation. To support the innovation and development of successful business models in a platform ecosystem, the Platform Canvas tool was created. With guiding questions, Platform Canvas allows for an ecosystemic approach to business model innovation: it helps to understand the value creation and capture for multiple actors. Originality/Value: The unique result is a practical tool, Platform Canvas, which facilitates business model creation in platform ecosystems.
An Empirical Analysis of the Effect of Education on Birth Rate Based on Chinese Provincial Panel Data

China’s birthrate is moving towards a dangerously low level. Based on the provincial panel data from the 2013-2017 China Statistical Yearbook and the population survey, through an empirical model, this paper analyzed the impact of education on the birthrate of a province and found that the illiteracy rate has a positive effect on the birthrate of a province; while the quality of basic education has a negative effect on it; there is no significant evidence that the proportion of higher-educated women in a province will affect its fertility. Finally, we put forward three suggestions for improving fertility level, optimizing population structure and enriching high-quality labor.
Análise das Propriedades Psicométricas do Questionário de Monitoramento Parental

Analysis of the psychometric properties of the Parental Monitoring Questionnaire Parental monitoring has been associated with academic performance, social competence, self-esteem, and adjustment in children and adolescents. The objective of the study was to study the psychometric properties of the Parental Monitoring Questionnaire (PMQ). In a prospective study performed in public schools, with students of the 5th (n=415) and the 6th years (n=379), the PMQ, the Brazil Test, the Self-Concept Assessment Questionnaire and the Multidimensional Life Satisfaction Scale for Children were applied, with two collections. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were carried out to evaluate the fit of the structural model. The EFA indicated two factors, paternal monitoring and maternal monitoring, confirmed in the CFA, with acceptable indicators of internal consistency and stability. The PMQ was associated with performance in Portuguese, self-concept and satisfaction with life, particularly regarding the family. Preliminary evidence of instrument reliability and associations suggestive of predictive validity justify further research to validate the PMQ.
Outcomes in people with Alcohol Dependence Syndrome treated in a Tertiary Care Hospital: A 3 month Prospective Cohort study

BACKGROUND : Alcohol use disorders are of great relevance to public health, and specifically to mental health professionals. Studies across the world and in India have shown a differing outcome to de-addiction treatment and various variables associated with favorable as well as unfavorable factors. More research is needed in the area of alcohol use in India focusing at identifying factors associated with positive and negative outcomes. AIMS AND OBJECTIVES : The present study aims at determining the proportion of completely abstinent persons in a cohort of newly diagnosed people with alcohol dependence syndrome at the end of 3month follow up period and examining the factors associated with complete abstinence. METHODOLOGY : This is a prospective cohort study which was conducted in the adult psychiatric units of Christian Medical College, Vellore.All newly registered patients with diagnosis of alcohol dependence syndrome were recruited from November 1st 2015 to April 30th 2016. Informed consent was taken. Initial assessment of socio-demographic factor and alcohol use history was done at recruitment. They were rated on SADD, CIWA-Ar, and the Rotter’s scale. Details of their status were collected either in person, or over the telephone, 3 months later. All clinical details for the interim period were extracted from the clinical files. Abstinence rates were calculated. The association between the pre-treatment and treatment variables and the outcome of interest were performed using Chi-square test and Fisher’s exact test. The factors associated with favourable outcome weresubjected to a multivariate logistic regression analysis. RESULTS : A total of 115 participants were recruited. Follow up data was incomplete for 17. Of the 98 participants who followed up, 30.6 % were completely abstinent. The factors significantly associated with complete abstinence were regularity with review visits, good adherence to medication, being prescribed Disulfiram, and receiving both pharmacological treatment and non-pharmacological treatment. Participant who had third degree relative using alcohol were more likely to be abstinent when compared to participants who had first and second degree relative using alcohol. DISCUSSION : Results are comparable to abstinence rates described in earlier studies. Clinicians could improve outcomes in this condition by focusing on use of combined pharmacological and non-pharmacological techniques, offering Disulfiram, encouraging regular review visits and using techniques to enhance adherence to medication.
Pengaruh Pengungkapan Emisi Karbon dan Kinerja Lingkungan Terhadap Nilai Perusahaan Pada Perusahaan Industri yang Tercatat Pada Bursa Efek Indonesia (BEI)

Carbon emission was defined as emission that accidentally released on production activities and energy providers, for example flaring and venting operation in oil and gas fields, gas leaks that occur at connection or valve in natural gas and CH4 gas. Disclosure plays a role to connect between the companies and the group of society. The companies are encouraged to gain legitimacy from the society because they want to ensure that their operational activities are appropriate with the norms and restrictions based on applicable regulations. Purpose of this research to analyze the effect of gas emission disclosure and environtmental performance on the firm value with total of assets, total of debt, and profitability as control variable on the industrial companies that listed in Indonesia Stock Exchange (IDX). The data used in this research is secondary data that obtained from annual report published by the Indonesia Stock Exchange through its official website www.idx. co.id. This research sample was taken by purposive sampling. The tests carried out in this research used descriptive statistical analysis, classic assumption tests, multiple linear regression analysis and hypothesis testing. The results of hypothesis testing indicate that gas emission disclosure and profitability has positive affect to firm value, while environtmental performance and total of debt do not affect to firm value. Keywords : Gas Emission Disclosure, Environtmental Performance, Firm Value
Autophagy-mediated regulation of neutrophils and clinical applications

Abstract Autophagy, an adaptive catabolic process, plays a cytoprotective role in enabling cellular homeostasis in the innate and adaptive immune systems. Neutrophils, the most abundant immune cells in circulation, are professional killers that orchestrate a series of events during acute inflammation. The recent literature indicates that autophagy has important roles in regulating neutrophil functions, including differentiation, degranulation, metabolism and neutrophil extracellular trap formation, that dictate neutrophil fate. It is also becoming increasingly clear that autophagy regulation is critical for neutrophils to exert their immunological activity. However, evidence regarding the systematic communication between neutrophils and autophagy is insufficient. Here, we provide an updated overview of the function of autophagy as a regulator of neutrophils and discuss its clinical relevance to provide novel insight into potentially relevant treatment strategies.
MiR-154 controls branching morphogenesis and alveologenesis in lung development involving Tgf-β signaling

Background: MiR-154 is abundant in neonatal lungs. Experimental evidence for a direct effect of miR-154 on lung development is still lacking. Aims and methods: We aim to investigate the effect of miR-154 by using an in-vivo gain-of-function ( CCSPrtTA/rtTA;tet(O)miR-154/+ ) and an in-vitro loss-of-function (morpholino) approach pre- and postnatally. Results: First, the expression of miR-154 from E10.5-P2 was analyzed by RT-qPCR and FISH. MiR-154 expression increased dynamically from E10.5 and peaks at P2. Attenuation of miR-154 in WT embryonic lung (CD1) harvested at E11.5 and treated with morpholino vs. control reveals a significant decrease in lung branching after 48h of culture. Prenatal overexpression of miR-154 from E7.5-E18.5 in CCSPrtTA/rtTA;tet(O)miR-154/+ mice (lung epithelial specific overexpression) and analysis of the lung structure by using alveolar morphometry shows increased mean linear intercept (MLI) and alveolar airspace but decrease in septal thickness indicating alveolarization defects. RT-qPCR reveals a decrease in Fgf10 signaling as well as markers for alveolar myofibroblast but increase in the epithelial marker EpCAM. In contrast, postnatal overexpression of miR-154 by using CCSPrtTA/rtTA;tet(O)miR-154/+ from P0-P16.5 leads to increased Fgf and Tgf-β signaling in the mutant group as well as increased MLI without changes in airspace and septal thickness. Interestingly, pull-down assay reveals caveolin 1 (Cav1), which is responsible for Tgf-β/Tgf-βR degradation, as a target of miR-154 . Conclusions: MiR-154 plays a crucial role in branching morphogenesis and alveologenesis by mediating Tgf-β signaling through caveolin 1.
Revisiting G-CSF Support for Hematologic Recovery after Autologous Transplantation in AML Patients

In acute myeloid leukemia (AML) patients, using granulocyte colony-stimulating factor (G-CSF) to support hematologic recovery in induction and consolidation treatment reduces the number of febrile episodes and the duration of neutropenia and hospitalization. However, the benefit and safety of administering G-CSF to enhance hematologic recovery in AML patients after autologous stem cell transplantation (ASCT) have not been reported so far. At our center, it was our policy to administer G-CSF after ASCT in all AML patients. In June 2015, increasing economic pressure prompted us to omit G-CSF after ASCT. In this retrospective study, we assessed the effects of changing our strategy from applying G-CSF for hematologic recovery after ASCT (in 103 AML patients) to omitting G-CSF (12 patients). We found that administering G-CSF shortened the median duration until neutrophil recovery was >0.5 G/l after ASCT by four days (P=.0001), and patients with G-CSF tended to have fewer bacteremias (38.3% versus 66.6%; P=.0654). The median duration of hospitalization was two days longer in patients without G-CSF support (25 versus 23 days; P=.0603). According to the Swiss in-patient reimbursement system, the shorter hospitalization of +G-CSF patients resulted in decreased total costs per patient of 3305 CHF (48 Mio U of G-CSF), and 3367 CHF (30 Mio U). Finally, no differences were observed in disease free (P=.0938) and overall survival (P=.7999) rates between +G-CSF versus –G-CSF patients. Our data suggest that G-CSF support after ASCT is safe and associated with shorter time until neutrophil recovery, fewer bacteremia episodes, shorter hospitalization, and lower costs. Keywords: Autologous; Transplant; AML; Leukemia; Recovery; Prognosis; Survival; Granulocyte-colony Stimulating factor; G-CSF; Consolidation
Cumulative effect of psychotherapy in remission of symptomatology of major depressive disorder

Background: Major depressive disorder constitutes the most commonly appeared psychological disorder. The aim of this study was to investigate the cumulative effect of psychotherapy over drug therapy in remitting depressive symptoms was examined. Method-materials: The sample consisted of 62 patients given the diagnosis of major depressive disorder who suffered in the past two years with at least 2 major depressive episodes. Additional inclusion criteria were, age of patients to be between 26-60 years old, onset of disorder ≥4 years, and weight of symptomatology having scores in MADRS ≥34 and in CGI ≥5. All patients were assigned randomly in four groups of combined therapy. The progress of depressive symptoms was measured with taxonomic manuals of psychological diseases MADRS from 1rst week of hospitalization, and every 3 weeks, until the 24 week of treatment. Results: Of the 42 participants, 24 were male and 38 female with mean age 42,3±8,8 years. The statistical significant improvement on depressive symptoms (p<0.001) occurred from induction week (MADRS=41) to the 6 week (MADRS=32) of hospitalization defined the level of remission of depressive symptoms. This remission mostly was a mixed effect of drug therapy and psychotherapy, since all 4 groups of patients showed similar decline in MADRS scores. Maintenance phase occurred about the 3 month of treatment (MADRS=14), at which point the greater cumulative effect over pharmacotherapy was that of psychodynamic-analytical therapy at 6 month with 52% remission (p<0.001) from baseline, while that of cognitive-behavioral therapy was 40%, and respectively only 22% for the supportive therapy. Conclusions: Remission rate of depressive symptoms occurred about the 6 week of hospitalization, with maintenance phase to occur at 12 week of treatment, time point at which psychodynamic and cognitivebehavioral psychotherapy had a statistical and clinical greater effect over drug therapy on remission maintenance of depressive symptoms compared to supportive therapy.
Die neue amerikanische Hypertonie-Guideline – wesentliche Inhalte und Bedeutung für Österreich // New US-Guideline for High Blood Pressure – facts and implications for Austria

New US-Guideline for High Blood Pressure – facts and implications for Austria. The new US-Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults has been released in November 2017. In this comprehensive document, containing 15 chapters and more than 170 pages, the currently available evidence is summarized, and guiding for the most important clinical questions regarding hypertension is provided. The new guideline have been widely discussed in the lay media, with an almost exclusive focus on the new blood pressure targets (< 130/80 mmHg). This review paper will give an overview on important aspects of the new US guideline, highlighting the new blood pressure targets and their possible implications for Austria. J Hyperton 2018; 22 (1): 5–8.
Exercise Time and Intensity: How Much Is Too Much?

The growing prevalence and popularity of interval training necessitate additional guidelines in regard to maximal levels of time and intensity. PURPOSE To correlate salivary hormones and time in varying heart-rate (HR) zones. The hypothesis was that chronic exercise durations >9% of total exercise time in the >90% maximum HR zone would lead to decreased variation in salivary cortisol concentration after exercise in a 2-bout high-intensity protocol compared with less or more time in this zone. METHODS A total of 35 healthy adults who regularly exercised for an average of 8 hours per week recorded their HR during every training session for 3 weeks. Later, they completed an experimental day composed of two 30-minute high-intensity interval sessions separated by 4 hours of nonactive recovery. The authors collected saliva samples before, immediately following, and 30 minutes after each exercise session to assess changes in cortisol concentrations. RESULTS There was a correlation between weekly time training at an intensity >90% maximum HR and the variables associated with overtraining. Salivary cortisol concentration fluctuated less in the participants who exercised in this extreme zone for >40 minutes per week (P < .001). CONCLUSION Based on the current study data, for individuals who regularly exercise, 4% to 9% total training time above 90% maximum HR is the ideal duration to maximize fitness and minimize symptoms related to overreaching.
Evaluation of corrected APHRODITE estimates for hydrological simulation in the Yarlung Tsangpo–Brahmaputra River Basin

Precipitation is one of the most important inputs for hydrological simulation because it controls water balance, and accurate representation of rainfall distribution is essential for hydrological simulation. In the Yarlung Tsangpo–Brahmaputra River Basin (YBRB), gauge‐based gridded datasets have difficulties in representing complex orographic precipitation as the rainfall stations are too sparse to capture accurate precipitation patterns. This study used Asian Precipitation Highly Resolved Observational Data Integration Towards Evaluation of Water Resources (APHRODITE) estimates to drive the Soil and Water Assessment Tool (SWAT) model in the YBRB. Bias correction on APHRODITE estimates was achieved through linear scaling based on a denser network of gauges. In addition, the elevation bands method was implemented in SWAT to reproduce spatial precipitation by considering orographic effects. The results showed that original APHRODITE data tended to systematically underestimate rainy season precipitation with considerable underestimation on windward slopes of the Himalayas. Corrected APHRODITE data increased precipitation estimates and were able to better represent the spatial patterns of precipitation. During the calibration and validation periods, the mean monthly Nash–Sutcliffe efficiency (NSE) of the corrected APHRODITE‐simulation were 0.86 and 0.82, respectively, which were much higher than those of the original APHRODITE‐simulation (0.79 and 0.72), indicating the reliability of corrected APHRODITE estimates in driving hydrological model. In addition, although the elevation bands method has some limitations induced by the constant precipitation lapse rate, it was also found that this method could improve the accuracy of hydrological simulation. In large transboundary sparsely gauged river basins, implementation of bias correction and elevation bands can improve the representation of spatial precipitation of gridded gauge‐based rainfall products, which may be beneficial for hydrological simulation and water resources management.
Securing E-Library System with Bimodal Biometric Technique

The project focuses on securing e-library system with dual biometric features viz: face recognition and fingerprint identification techniques. The results obtained from the research support the set of objectives. The findings indicate that a real time fingerprint and face based authentication security system can be achieved. For the fact that it involves the use of human and biological characteristics, thus some false rejections were recorded during the performance of the system, this occurs mostly in the section of face recognition. This is as a result of the conditions under which the face images were acquired (that is, image background, lightening, distance of face from camera, etc.). The function of the system is based on the ability to match a required fingerprint and face within the database in order to authenticate the user of the facility and therefore grant or refuse access to the electronic library and this was achieved as reported in the paper.
Percepción de un grupo de docentes de educación primaria acerca de la preparación recibida durante su formación universitaria en cuanto al tema de las Matemáticas

Professionals trust that what they have learned in their initial training will be useful in their working life. However, the changing society in which they live makes this a volatile fact, especially in careers related to education, since changes in society make the country’s educational curriculum change. Consequently, college education must be comprehensive and provide a good foundation for self-formation, if necessary. This article is about the perception of a group of teachers of cycles I (1st to 3rd grade) and II (4th to 6th grade) of the General Basic Education of Costa Rica about their initial college education. Reporting about this perception has as aim to raise awareness, among the various actors that interfere in teacher training, about the aspects that can be improved in said training. The study was quantitative and descriptive. Data were collected from 121 elementary teachers from different educational regions in the country using a questionnaire in 2017. Regardless of the type of university from where they graduated, respondents felt that their initial college education had not been sufficient to meet classroom challenges. Teachers are not satisfied with their college education because they consider that some areas of the current Math curriculum were not addressed correctly, regarding content knowledge, as well as didactic content. The foregoing shows, on the one hand; the urgent need to establish professional development processes for these teachers to be trained in the required subjects; and on the other side, the urgent demand of making a Math curriculum upgrade of colleges.