Miracle-dz/UniFAR-FTUs huggingface dataset:
A Compact Interface Between Adiabatic Quantum-Flux-Parametron and Rapid Single-Flux-Quantum Circuits

Each superconductor logic family has distinct features and advantages. For instance, adiabatic quantum-flux-parametron (AQFP) circuits operate with very high energy efficiency, and rapid single-flux-quantum (RSFQ) circuits operate at very high clock frequencies. To build a hybrid system that combines the above advantages, we propose a compact interface between AQFP and RSFQ circuits that converts current signals in AQFP logic into flux signals in RSFQ logic using a non-adiabatic quantum-flux-parametron gate. Compared to a previously proposed AQFP/RSFQ interface, the proposed interface has far fewer Josephson junctions (4 vs. 11). We optimize the circuit parameters of the AQFP/RSFQ interface and demonstrate the interface at low speed as proof of concept. Furthermore, we demonstrate data propagation between AQFP circuits along a long passive transmission line via the AQFP/RSFQ interface at low speed to show that the AQFP/RSFQ interface can alleviate the interconnect length limit in AQFP circuits.
REACTIVE ESTER-URETHANE PREPOLYMER AS BIOADHESIVE: SYNTHESIS AND EVALUATION

Reactive urethaneprepolymer, as a base material forthe process ofgluing in medicine, has been studied. For this purpose castor oil and toluene diisocyanate(FDI) were used as polyol and diisocyanatecomponents to synthesize the isocyanate terminated urethane prepolymer . The molecular structure of this prepolymer was investigated by infrared spectroscopy (FTIR) and vapour pressure osmometry (VPO). The obtained infrared spectrum confirmed the presence of free NCO groups bonded to the prepolymer back- bone. The wettingbehaviour of the synthesized prepolymer was evaluated by surface tension measurement . The surface behaviour of the cured thin films of the prepolymer was characterized using contact angle measurements . The cytotoxicity of the cured prepolymer film was evaluated by in vitro cell culture experiment. Results showed a compatible cell response with no signs of toxicity.
Advanced Switching Sequences Based Model-Predictive Control for Single-Phase NPC Converters

This article presents a continuous control set model-predictive control (MPC) technique based on advanced switching sequences (SSs) for a grid-connected single-phase three-level neutral-point-clamped converter. The SSs are developed considering the tracking performance of the current feed to the utility grid, the dc-bus capacitor voltage balancing, and the switching loss of the semiconductor devices. In the proposed strategy, with the same sampling frequency, the number of pole state changes (SCs) per control cycle is only two, while in the optimal SS and the modulated MPC (pulse pattern similar to the conventional space vector modulation technique) schemes, the number of pole SCs is four. The reduction in the number switching SCs per control cycle considerably reduces the switching loss of semiconductor devices. Moreover, to avoid the challenges of utilizing the weighting factor, a single-objective cost function is adopted to track the reference current, and the dc-bus capacitor voltages are balanced using the redundancy nature of the voltage vectors. Furthermore, the proposed scheme can ensure a fixed-switching-frequency operation, which is advantageous for selecting filter parameters during real-life implementation. The effectiveness of the proposed strategy is validated by the results obtained from both the simulation in MATLAB/Simulink and the experiment carried out using a downscaled laboratory test rig.
Psoralen alleviates high glucose-induced HK-2 cell injury by a mechanism involving miR-847 upregulation

Background Diabetic nephropathy (DN) causes the vast proportion of excess mortality for patients with diabetes. Novel therapeutic approaches slowing down its incidence is still lacking. Psoralen is the major active ingredient of Psoralea corylifolia Linn. (PCL), which was used to treat a number of diseases. In this study, we aimed to investigate whether psoralen could alleviate DN and to explore the underlying mechanisms. Methods Cell viability assay and immunofluorescence were used to evaluate the effect of psoralen on high glucose (HG)-stimulated human kidney HK-2 cells. RT-qPCR was used to detect the expressions of miRNA in cells. Cell transfection, apoptosis assay and Western blot were further performed to explore the underlying molecular mechanisms. Results Psoralen alleviated HG-induced viability decrease of HK-2 cells via inhibiting apoptosis. Meanwhile, the secretion of inflammatory cytokines and extracellular matrix (ECM) accumulation induced by HG in HK-2 cells were also decreased by psoralen. In addition, the expression of miR-874 in HK-2 cells was significantly upregulated by psoralen. Western blot assays indicated that psoralen inhibiting TGF-β1/Smad2 signaling via upregulation of miR-874. Conclusion This study demonstrated that psoralen could significantly alleviate HG-induced HK-2 cell injury via upregulation of miR-874. Therefore, psoralen might serve as an agent for the treatment of DN.
A Pan-cancer analysis of GPR183 correlated with tumor immunity

Background G-protein-coupled receptors(GPRs) are the largest family of membrane proteins in the human genome, positively involving in human physiological and metabolic activities. Drugs targeted to GPRs have developed fast. However, there are still few GPR-targeted drugs for cancer treatment. GPR183, an orphan seven-transmembrane receptor, have been widely studied in immune regulation. Yet, its role in tumor immunity remains mysterious.Results In our study, we performed a pan-cancer analysis of GPR183. Though statistically significantly differed between tumor and normal samples in various cancers, the expression of GPR183 showed a dual trend. Besides, we applied integrated network analysis to predict GPR183 related genes and analyzed their function with GO and Pathway analysis. GPR183 was strongly associated with immune responses. Moreover, we evaluated the prognostic value of GPR183 in various cancers and found it related to the prognosis of BRCA, SKCM, LUSC, LGG and UVM. We further explore its immunoregulatory function based on differentially expressed genes. Finally, we estimated the tumor immune infiltration associated with GPR183 expression using “TIMER”. The GPR183 expression was highly correlation with macrophages and dendritic cells infiltration.Conclusions GRP183 showed a multiple immunoregulatory role in tumor progression. GPR183 was related to prognosis of five cancer types(BRCA, SKCM, LUSC, LGG and UVM). We also found GPR183 had intimate connection to PD-1 signals. GPR183 might become a potential therapeutic target for cancer treatment.
Transmissão de energia no interferômetro de Mach-Zehnder de fibra de cristal fotônico com modulação PWM

Resumo— Este artigo apresenta um estudo sobre o funcionamento de um dispositivo totalmente óptico baseado em acopladores direcionais não-lineares baseados em fibra de cristal fotônico de núcleo duplo. Analisou-se a transmissão e a interação da energia entre os pulsos dos guias de onda por meio da modulação por largura de pulso, levando em consideração a potência de entrada, a modulação dos pulsos e a diferença de fase. O estudo numérico utilizou o método de Runge-Kutta de quarta ordem para resolver o par de equações de modo acoplado considerando os efeitos não-lineares de automodulação de fase, modulação de fase cruzada, efeito Raman e auto-inclinação. Além dos efeitos lineares de dispersão de segunda e terceira ordem.
Identification of an immune gene signature with prognostic value for patients with uterine corpus endometrial carcinoma

Background: Uterine corpus endometrial carcinoma (UCEC) is a very common gynecological malignancy with a poor prognosis in the late stage. Therefore, the purpose of this study was to determine an immune-related gene signature that predicts the patients’ OS for UCEC. Methods: Based on TCGA, ImmPort, and Cistrome databases, the differential immune genes were screened and the TFs regulatory network was constructed. Functional enrichment and pathway analysis of differential immune genes were carried out. Prognostic value of 410 immune genes was analyzed by Cox regression analysis, a prognostic model was constructed, ROC curves were used to verify the accuracy of the model, and independent prognostic analysis was performed. Finally, the immune cell content was obtained by TIMER, and the correlation with the immune gene expression was evaluated by univariate Cox regression analysis. Results: It was found that the immune cell microenvironment and PI3K-Akt, MARK signaling pathways were involved in the development of UCEC. Based on the established prognostic model, ten-gene prognosis signature (PDIA3, LTA, PSMC4, TNF, SBDS, HDGF, HTR3E, NR3C1, PGR, CBLC) for UCEC prognostic prediction were finally identified, and our study has shown that risk-score can be a powerful prognostic factor for UCEC, independent of other clinical factors. The levels of B cells and neutrophils may be significantly correlated with the patient's risk score. Conclusions: Our studies showed that the ten-gene prognosis signature had important clinical value for the prognosis of UCEC, which was helpful for individualized treatment and provided a new target for tumor immunotherapy.
The deleterious effect of the HLA-C1/KIR2DL3 receptor-ligand combination in Chinese HIV patients

Background The combination of KIR-HLA affects the prognosis of HIV infection, and polymorphisms of KIR and its ligand HLA differs between regions and races. Few research has focused on the effects of the KIR-HLA combination on the prognosis of HIV-infected individuals in China. Methods Peripheral blood samples were collected from newly diagnosed and treatment naïve HIV-infected patients and processed according to the study design. Their clinical data and other demographic information were recorded. The genomic DNA of the host was extracted from whole blood samples, and KIR genotyping was performed using sequence specific primer amplification (PCR-SSP). The HLA genotyping was performed using sequence analysis (PCR-SBT), and the HLA-KIR genotyping and combination information were obtained. Fisher’s exact test was used for the comparison of categorical variables between groups, and the Mann-Whitney test was used for continuous variables. Results The baseline HIV level in patients with an HLA-C1+/KIR2DL3+ background was significantly higher than that in patients with an HLA-C1+/KIR2DL3- (4.34 log10 copies/ml vs. 3.72 log10 copies/ml, P=0.02). The baseline CD4/CD8 ratio of HLA-C1+/KIR2DL3+ patients was significantly lower than that of HLA-C1+/KIR2DL3- patients (0.33 vs. 0.56, P=0.02). The plasma soluble CD14 level at baseline was significantly lower in HLA-C1+/KIR2DL3- infected persons than HLA-C1+/KIR2DL3+ patients (P=0.03). Conclusions HIV-infected persons with the combination of HLA-C1+/KIR2DL3+ had a much higher HIV set point, higher baseline sCD14 levels and lower baseline CD4/CD8 than patients without this combination. The receptor-ligand combination of HLA-C1+/KIR2DL3+ has a deleterious effect in Chinese HIV patients.
Mechanical Properties of a Polymer at the Interface Structurally Ordered by Graphene

In this study, for the first time, molecular dynamics simulations helped identifying the substantial mechanical properties changes of a crystallizable polyimide related to the ordering of the polymer chains along the graphene surface. It is demonstrated that graphene-induced polymer ordering at the nanofiller–polymer interface leads to mechanical properties exceeding those of the unfilled amorphous polymer. Moreover, simulation results confirm that the mechanical properties anisotropy is related to the polymer ordering anisotropy induced by graphene–polymer interactions.
Effect of CPPU on fruit and shoot growth of apple

The effects of CPPU on the growth of fruits and bourse shoots of apple were examined by targeted applications of 20 mg I“1 CPPU to fruitlets and/or bourse-shoot and spur leaves. Treating fruitlets and fruitlets-plus-leaves stimulated fruit growth to a similar extent; fruit growth rate was temporarily suppressed when only the leaves were treated. Conversely, bourse shoot growth was stimulated by leaf and leaf-plus-fruit treatments. All CPPU applications reduced the content of fruit soluble solids and induced a paler yellowish- green fruit ground colour.
Grasping Robot Integration and Prototyping: The GRIP Software Framework

Robotic manipulation is fundamental to many realworld applications; however, it is an unsolved problem that remains a very active research area. New algorithms for robot perception and control are frequently proposed by the research community. These methods must be thoroughly evaluated in realistic conditions before they can be adopted by industry. This process can be extremely time consuming, mainly due to the complexity of integrating different hardware and software components.
Literature contributions of a paediatric cardiologist to adult congenital heart disease - Part I

The author’s contributions with regard to defects in the atrial septum, namely, secundum atrial septal defects (ASDs) and patent foramen ovlae (PFO) will be reviewed. Successful closure with the buttoned device with excellent immediate and follow-up results was demonstrated in patients with 1. ostium secundum ASDs, 2. patent foramen ovale (PFO) presumed to be the seat of paradoxical embolism, 3. residual ASDs/PFOs with right-to-left shunt following prior cardiac surgery, and 4. ASDs/ PFOs resulting in platypnea-orthodeoxia syndrome. Also reviewed was why, when and how should ASDs be closed in adults. Since the buttoned device is no longer available for clinical use, now the author utilizes other devices, namely, Amplatzer and Gore Septal occluders instead.
Inhibition Effect of Taurine on Myocarditis and Myocardial Fibrosis Followed by Myocarditis

OBJECTIVE To investigate the inhibition effect of taurine (Tau) on the myocarditis induced by Coxsackie virus and adriamycin,and myocardial fibrosis followed by myocarditis and its mechanism.METHODS ①The model of viral myocarditis was built by Coxsackie virus B3 in mice,meanwhile,mice were treated with Tau 1 000,500 and 250 mg·kg-1·d-1 by gastrointestinal administration. The contents of lactate dehydrogenase (LDH),aspartate amino transferase (AST),reatine kinase isozyme(CK-MB)and the activity of superoxide dismutase(SOD) in blood serum were assayed respectively. The changes of myocardial ultrastructure were observed by electronic microscope. ②The model of myocarditis in rats was built by intraperitoneal injection of adriamycin(ADR) for 2.5 mg·kg-1·week-1. Meanwhile,rats were treated with Tau 400,200 and 100 mg·kg-1·d-1 by gastrointestinal administration. The contents of LDH,AST,CK,malondialdehyde (MDA)and activity of SOD were measured. TGF-β1 and TNF-α levels were determined by the ELISA.Histopathology changes were detected by HE staining. RESULTS ①Compared with model group,the contents of LDH,AST and CK-MB of blood serum were significantly reduced and the activity of SOD was markedly enhanced in Tau 1 000 and 500 mg·kg-1·d-1groups(P0.05 or P0.01). The results of electron microscope showed that Tau relieved myocardial damage induced by Coxsackie virus B3. ②Compared with model group,the contents of LDH,AST,CK,MDA were decreased in Tau groups (400,200 mg·kg-1·d-1). The activity of SOD was increased and the contents of TGF-β1,TNF-α were decreased(P0.05 or P0.01). The cardiac myocytes were arranged disorder. Tau relieved the damages of myocardium caused by adriamycin.CONCLUSION Tau can inhibit the damages of myocardium caused by Coxsackie virus B3 and adriamycin through antioxidation,inhibit myocardial fibrosis followed by myocarditis by inhibition the expressions of TGF-β1 and TNF-α.
Serum Free T4 Concentration: More Accurate and Reliable than TSH as an Indicator of Thyroid Gland Function

Objective: To compare the accuracy and reliability of Free T4 or TSH determination as the single initial screening test in assessment of thyroid function. Methods: Retrospective review of 3,022 thyroid function tests (free T4 and TSH) performed during a 12 month period in a laboratory at a major academic medical center was conducted. A probable diagnostic category for each test was determined by a retrospective detailed review of medical records of subjects with discrepant serum free T4 and TSH concentrations. Results: In 284 tests (9.4%) the appropriate diagnosis could not be arrived at if serum TSH concentration alone was used for interpretation of thyroid function. Alternatively, serum free T4 concentration alone was unable to provide accurate diagnosis in 132 (4.4%) subjects. Multivariate analysis determined that free T4 is more reliable than TSH as an initial test for the diagnosis of thyroid function as expressed by odds ratio (OR) 2.14 with confidence interval (CI) 1.96 - 2.34, p< 0.01. The sensitivity and specificity for diagnosis of thyroid disorder were superior for Serum free T4 concentration (91% and 94%) respectively when compared with serum TSH level (84% and 86%). However, the sensitivity and specificity for both laboratory tests assessed in conjunction improved further ( 98% for both) in comparison to either of the tests evaluated individually in diagnosis of thyroid disorder. Conclusions: Free T4 may be more accurate and reliable than TSH as a single initial screening laboratory test in assessment of thyroid function. However, both performed simultaneously increases the reliability and accuracy in determination of thyroid functional state.
Tomato breeding for disease resistance

In the genetic breeding of tomatoes, not only productivity, but also factors related to fruit quality and pest and disease management are taken into account. In this context, diseases stand out, since they are the main bottlenecks for successful cultivation. Currently, the search for more sustainable crops has demanded from producers’ alternatives to disease control to reduce the use of pesticides. Among the diseases that most reduce tomato production in Brazil, whether for table or industry, we can mention late blight, black spot, fusarium wilt, viruses, bacterial and nematode diseases. Genetic resistance, obtained by genetic breeding programs, is one of the best tools to deal with diseases to depend less on pesticides. Thus, this review aims to provide an overview of tomato breeding programs in terms of resistance to the main diseases that affect this crop.
Detection of Breast Pathology using Thermography as a Screening Tool

Thermal imaging is an emerging, low-risk modality for early breast cancer decision making without injecting any form of energy into the body. To reduce the burden on radiologists, use of automation is suggested to facilitate better interpretation of thermal images. Hotspots are segmented in the thermograms by k-means clustering algorithm. The features of left and right breasts are more correlated for normal cases and are less correlated for abnormal patients. The investigation results reveal that significant difference in feature values of left and right breast of an abnormal patient is depicted by first order statistical features, namely, kurtosis and variance.
A review of uncertainty quantification for density estimation

It is often useful to conduct inference for probability densities by constructing “plausible” sets in which the unknown density of given data may lie. Examples of such sets include pointwise intervals, simultaneous bands, or balls in a function space, and they may be frequentist or Bayesian in interpretation. For almost any density estimator, there are multiple approaches to inference available in the literature. Here we review such literature, providing a thorough overview of existing methods for density uncertainty quantification. The literature considered here comprises a spectrum from theoretical to practical ideas, and for some methods there is little commonality between these two extremes. After detailing some of the key concepts of nonparametric inference – the different types of “plausible” sets, and their interpretation and behaviour – we list the most prominent density estimators and the corresponding uncertainty quantification methods for each.
On Determining of LTI Systems Having Nondecreasing Step Response

This brief mainly focuses on discussing computational method of determining whether step responses are nondecreasing for linear time invariant (LTI) systems, including negative real pole systems and complex pole systems. A modified theorem of Jayasuriya and Dharne and a useful fact are offered to deal with negative real pole systems which may have right half plane (RHP) zeros. A necessary condition is presented for complex pole systems to have non-decreasing step responses. Besides, an approximated method is further given as an improvement for determining step responses of complex pole systems.
Design and fabrication of a compact microstrip triplexer for wimax and wireless applications

A novel structure to design a microstrip triplexer for wireless and WiMAX applications is presented. To obtain a compact microstrip layout, step impedance resonators and coupled lines are used. The introduced triplexer has a size of 0. 35λg×0. 26λg, where λg is calculated at 2.3 GHz. Also, the obtained insertion losses are 0.78 dB, 1.1 dB and 0.62 dB at 2.3 GHz, 3.2 GHz and 3.6 GHz, respectively. The LC model of the presented resonator is investigated to tune three resonance frequencies by calculating numerical values of inductors and capacitors. Finally, the designed triplexer is simulated and measured.
COVID 19: Physiotherapy performance in a pediatric intensive care unit

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new coronavirus who emerged in 2019 and causes Coronavirus Disease 2019 (COVID-19) that is highly contagious and differs from other respiratory viroses. The transmition occurs by human-to-human approximately 2 to 10 days prior to the individual becoming symptomatic [1-4]. The COVID-19 in children is often less severe than in adults. It is children were usually well cared for at and might have relatively less opportunities to expose themselves to pathogens and/or sick patients. The angiotensin converting enzyme II (ACE2) is known as a SARS-CoV-2 /receptor and evidence has indicated that these receptors in children have less maturity and function than in adults. the or The higher younger children < 1 year of 3% In 13 critical cases, 7 younger than 1 year and only a 14 years old boy
Characterization of Elastomers and Rubber Chemicals by Modern NMR Techniques

Abstract High resolution NMR has undergone a revolution in the last ten years or so. The ability to manipulate spin systems to a high degree in the pulse FT NMR experiment, coupled with advances in NMR computing systems, has led to the design of many multipulse and two-dimensional (2-D) NMR experiments which can provide considerably more information than a standard spectrum. In addition, experiments to obtain high resolution NMR spectra of solid materials have opened a whole area of chemistry to NMR. The new interpretive techniques for spectra obtained in solution have been applied to synthetic polymers or polymer chemicals only recently. However, the solid-state methods already have seen wide application in the polymer area. In this report, we describe some work from our laboratory employing some of these advanced methods in both solution and the solid state. This is not meant to serve as a detailed discussion of the techniques employed, but rather as an introduction to potential applications in the rubb.