Miracle-dz/UniFAR-FTUs huggingface dataset:
Outcome of Heart Valve Prosthesis in a Tertiary Care Hospital in Bangladesh: A Retrospective Study

Background: Prosthetic heart valve for middle aged patients requiring valve replacement remains controversialBecause of the co-morbidities and limited life expectancy, bioprosthesis is the likely choice for older aged patients. Objective: The aim of the study was to quantify long term survival rate and major morbidity in patients undergoing heart valve replacement and to optimise selection criteria of biologic versus mechanical valve prostheses. Methods: This retrospective cohort study evaluated among 565 patients of 45 to 65 years of age undergoing isolated, primary heart valve replacement in either aortic or mitral position using mechanical or bioprosthetic valve. Results:Long time survival benefit was similar between aortic valve replacement (AVR) versus mitral valve replacement (MVR) patients regarding replacement with either mechanical and bioprosthetic valve. Postoperative incidence of morbidities like valve related complications, endocarditis, and bleeding were statistically not significant in this study. There was no significant difference in terms mortality after both AVR and MVR regarding use of bioprosthesis versus mechanical valve. Although, most common causes of mortality were prosthesis related and haemorrhage that was observed in both study group. Follow up at 10 years observed mean survival rate were 86.6%, 90.3% in mechanical AVR and MVR respectively, whereas patients with bioprosthesis demonstrate survival rate of 82.3% after AVR and 76.9% following MVR. Conclusion: With a life expectancy of at least 15 years, mechanical prostheses should be considered in patients below 50 years in Bangladesh. However, patients more than 50 years of age or with multiple comorbidities like coronary artery disease, renal disease, lung disease, coronary disease, or a life expectancy less than 15 years, bio prostheses may be good options for better outcome.
Minimum wood density of conifer species portrays changes in spring precipitation at dry and cold Eurasian sites from the Mediterranean and steppe biomes

Instituto Pirenaico de Ecología (IPE-CSIC), Avda. Montañana 1005, E-50059 Zaragoza, Spain Forest Ecology and Restoration Group, Department of Life Sciences, University of Alcalá, E-28802 Alcalá de Henares (Madrid), Spain Sukachev Institute of Forest SB RAS, Akademgorodok 50/28, 660036 Krasnoyarsk, Russia Institute of Ecology and Geography, Siberian Federal University, pr. Svobodny 82, 660041, Krasnoyarsk, Russia Department of Evolutionary Biology, Ecology and Environmental Sciences, University of Barcelona, 08028 Barcelona, Spain Department of Forestry, Siberian Federal University, 660041 Krasnoyarsk, Russia Institute of Plant and Animal Ecology SD RAS, 8 Marta Str. 202, Yekaterinburg, 620144, Russia Department of Crop and Forest Sciences-AGROTECNIO Center, Universitat de Lleida, Rovira Roure 191, E 25198 Lleida, Spain
Genetic Variation and Gene Flow at the Range Edge of Two Softshell Turtles

Abstract The movement of riverine animals can greatly impact the distribution of genetic variation among populations. The limited dispersal of reptiles and amphibians can produce significant genetic differentiation among geographically proximate populations. Studying the factors that contribute to genetic variation at the poleward edge of species' ranges may be particularly important as ranges shift in response to climate change. We examined physical movement and the distribution of genetic variation among populations of two riverine softshell turtle species, Apalone spinifera and Apalone mutica in Minnesota. We sequenced the mitochondrial control region and genotyped six variable microsatellite loci for 220 turtles across three river systems. Using radiotelemetry, we monitored aquatic movement and tested for sex differences in movements among 19 turtles. We found no evidence of genetic differentiation at geographic scales yielding significant differentiation in other freshwater turtles, a trend that may be attributed to high motility of Apalone turtles. The presence of dams separating several sites was not associated with genetic differentiation, likely owing to the young age of the dams relative to the generation times of Apalone. Although we found no directional gene flow toward peripheral populations, we observed the highest genetic variation in the populations closest to the range center in both species. Our findings highlight the role of physical movement on the distribution of genetic variation in riverine turtles, a relationship that may impact adaptability to climate change and other anthropogenic alterations.
Forecast Stock Prices with Markov Model

: Due to the tremendous interests of several large corporations, making stock market predictions has always been one of the most activated research fields. However, forecasting stock prices has been restricted by huge factors regarding its characteristics of volatility, seasonality and unpredictability. In 1991, Grant Mcqueen and Steven Thorley, who are Professors of Finance at BYU Marriott School of Management, conduct examination of predicting stock prices by using Markov Chains. In 2005, Hassan and Nath used only one HMM that is trained on the past dataset of the chosen airlines to forecast the stock prices of these companies. After reading two journals regarding different approaches, it was not hard to notice that these methods actually were conducted based on contradicted assumptions. It appears that the transition of methods used in order to predict stock prices has been well developed, and this recent study in 2005 has overturned the past premise on random walks theory, which suggested stock prices can also be predicted by using existing patterns. Finally, people can improve the prediction accuracy by combining AI technology and HMM according to Hassan and Nath, which is the future researches in this field. After reading these all five journals, this paper focus on the trading history on the stock market of Alibaba Group. Then researcher sees the history data during the last five years as training data, so it is possible to make reasonable predictions for the following days based on the transition matrix, which is founded from the training data.
Death Receptor Fas as Molecular Target of Soursop Leaves Novel Isolate in Liver Cancer Targeted Therapy

In the past few decades, no effective systemic therapeutic modalities established in the unresectable liver cancer stage, so the prognosis remains poor. Apoptotic dysregulation of cancer cells through Fas gene expression linked to tumor development, progression, and resistance to treatment. Soursop plants believed to have potent anticancer activity. It hypothesized that active compounds in the soursop leaves would induce apoptosis by interfering with Fas gene expression in liver cancer cells. The study objective was to explore the role of an isolated from soursop leaves against Fas gene expression in liver cancer cells. This study used the HepG2 cell line culture, and treatment groups were given novel isolate (SF-1603) from soursop leaves with three different doses which conducted in Bandung in 2017. Observations assessed in hours 0, 24, 48, and 72. Measurement of gene expression was done with real-time PCR and apoptosis detection by the TUNEL method. The results showed that the novel isolate (SF-1603) from soursop leaves stimulate Fas optimum expressions to initiate apoptosis with 0.5×inhibitory concentration 50 (IC 50 ) dosage at observation hour 48. There was a strong correlation between Fas gene expression with the apoptosis level. It concluded that the novel isolate (SF-1603) from soursop leaves is a potent anticancer that affects Fas gene expression in apoptosis induction on the liver cancer cell. It can be used as a candidate for a new therapeutic agent for liver cancer treatment. RESEPTOR FAS SEBAGAI SASARAN MOLEKULER NOVEL ISOLAT DAUN SIRSAK PADA TERAPI BER TARGET KANKER HATI Dalam beberapa dekade terakhir, tidak ada modalitas terapi sistemik yang efektif untuk pengobatan kanker hati tahap lanjut sehingga prognosisnya buruk. Disregulasi apoptosis sel kanker melalui ekspresi gen Fas terkait dengan perkembangan, perkembangan tumor, dan resistensi terhadap pengobatan. Tanaman sirsak dipercaya memiliki aktivitas antikanker yang kuat. Senyawa aktif dalam daun sirsak secara hipotesis dapat menginduksi apoptosis dengan memengaruhi ekspresi gen FAS pada sel kanker hati. Tujuan penelitian adalah mengeksplorasi peran isolat daun sirsak terhadap ekspresi gen Fas pada sel kanker hati. Penelitian ini menggunakan kultur sel kanker HepG2 dan kelompok perlakuan diberi isolat baru (SF-1603) daun sirsak dengan 3 dosis berbeda yang dilakukan di Bandung pada tahun 2017. Pengamatan dinilai pada jam ke-0, 24, 48, dan 72. Pengukuran ekspresi gen dilakukan dengan PCR real-time dan deteksi apoptosis dengan metode TUNEL. Hasil penelitian menunjukkan bahwa novel isolat (SF-1603) daun sirsak menstimulasi ekspresi optimal Fas untuk inisiasi apoptosis dengan dosis 0,5× inhibitory concentration 50 (IC 50 ) pada pengamatan 48 jam. Terdapat korelasi yang kuat antara ekspresi gen Fas dan tingkat apoptosis. Disimpulkan bahwa isolat baru (SF-1603) daun sirsak adalah antikanker kuat yang memengaruhi ekspresi gen Fas dalam induksi apoptosis pada sel kanker hati sehingga dapat digunakan sebagai kandidat agen terapi baru untuk pengobatan kanker hati.
Integration of Geology , Remote Sensing and Geographic Information System in Assessing Groundwater Potential of Paiko Sheet 185 North-Central Nigeria

An integrated geologic, Remote Sensing (RS) and Geographic Information System (GIS) techniques have been adopted to assess the groundwater potential of Paiko Sheet 185 North-Central Nigeria in order to reduce failure of developing groundwater resources by delineating prospective aquifer zones from poor aquiferous zones. The study area, which is about 3025 km, is dominated by crystalline basement rocks comprising of migmatites, granites, amphibolites and schists. Sandstones and alluvial deposits are also present. Digitally enhanced colour composites and band 5 Landsat ETM+ were used to produce thematic maps of lineaments and land use/cover. Shuttle Radar Topographic Mission (SRTM) Digital Elevation Model (DEM) was utilized to map geomorphology and topographic parameters such as slope and drainage systems. Five thematic maps were produced which included land use/ land cover, drainage density, slope, lithology and lineament density. These were integrated and analysed using ArcGIS 10.0 software. All the thematic layers were then assigned weights according to their relative importance in groundwater occurrence and the corresponding normalized weights were obtained based on the Saaty's analytical hierarchy process (AHP). GIS modeling technique employing the weighted overlay method was used to produce groundwater potential map. Four groundwater potential zones were identified namely: “very good”, “good”, “moderate” and “poor”. The spatial distribution of groundwater zones show regional patterns related to lithology, lineaments, drainage systems and landforms. Very high and high potential zones correspond to areas composed of alluvial deposits, sedimentary rocks and high lineament densities. Moderate zones fall on areas within the channel plains, while the low potential zones fall around fresh rock exposures, ridges and peaks which contribute to high run-off. This study has shown that integrating remote sensing and GIS with a sound knowledge of geology is very effective in assessing groundwater potentials on regional scale.
Regulation of the Mitochondrial Permeability Transition Pore: Role of Outer Membrane and of Translocator Protein (Peripheral Benzodiazepine Receptor)

The mitochondrial permeability transition (PT) is a sudden increase in the permeability of the inner mitochondrial membrane (IMM) to solutes with molecular masses up to 1,500 Da. This process is due to opening of a voltage- and Ca2+-dependent, cyclosporin (Cs) A-sensitive, high-conductance channel called the permeability transition pore (PTP). Its involvement in pathological states and in the loss of cell viability is widely recognized, but its molecular identity remains elusive. The long standing idea that the PTP may form at inner-outer membrane contact sites and that it may be constituted by the adenine nucleotide translocator (ANT) in the IMM and voltage dependent anion channel (VDAC) in the outer mitochondrial membrane (OMM) has not been confirmed by genetic ablation of these proteins. Yet, the PT can be regulated by proteins that interact with the OMM such as hexokinase, and by ligands of the OMM translocator protein of 18 kDa (TSPO, formerly known as peripheral benzodiazepine receptor). TSPO is highly conserved throughout evolution and was first identified as a binding site for benzodiazepines in tissues that lack GABA receptors, the clinical target of benzodiazepines in the central nervous system. Moreover, TSPO together with VDAC and ANT was included in the early models of PTP and as of today remains the only putative PTP component whose role has not been addressed by genetic inactivation. Thus, we first investigated the role of OMM in PTP regulation; and then created mice where Tspo gene could be inactivated. We demonstrate that (i) PT is exclusively an IMM event, as it occurs in mitoplasts (mitochondria stripped of outer membranes); (ii) in the presence of specific, high affinity TSPO-ligands, such as PK11195, Ro5-4864, FGIN1-27 and protoporphyrin (PP) IX the PT is observed in rat liver mitochondria, but not in mitoplasts; and (iii) upon photooxidative stress (achieved by photoirradiation after treatment with PP IX-like dicarboxylic porphyrins), low doses of light inactivate the PT both in mitochondria and in mitoplasts while high light doses activate the pore in mitochondria only. Conditional elimination of TSPO in mouse livers abolished high affinity binding of the TSPO ligand PK11195, but it did not prevent: (i) CsA-sensitive PTP formation; (ii) PT induction by TSPO ligands PK11195, Ro5-4864 and PP IX; (iii) PT induction by photooxidative stress. The latter findings are unequivocal demonstration that the ability of ‘specific’ TSPO ligands to regulate PTP is due to off-target effects, possibly at the FoF1 ATP synthase.
Hubungan Antara Self Efficacy dengan Kreativitas Pada

Kata kunci: The purpose of this research was to know whether there was a relation between self efficacy and creativity on Vocational High School students. This type of research, including explanotary research, because it aimed to explain the relation between the variables through hypothesis. This research was conducted on students of Sekolah Menengah Kejuruan Negeri 8 Surabaya by the number of the study subjects were 62 students who are XI grader Fashion Boutique Competency Skills.The analysis of the research data obtained by the coefficient correlation between self efficacy with creativity of 0,479 with the p value of 0,000. It has shown that there was a significant relation between self efficacy with creativity on Vocational High School students, the increase of self efficacy, followed by an increase in creativity.
Research on the Influence Model of Technology Introduction and Intellectual Property Protection on Enterprise Innovation

In previous studies, technology introduction and intellectual property protection are considered to be important factors affecting enterprise innovation. On this basis, this paper firstly analyzes the influence of the combination of these two factors on enterprise innovation, holds that they can both promote and inhibit enterprise innovation ability. According to the local environment, human capital level and enterprise heterogeneity, the influence degree is not the same, or even completely opposite. Based on the theoretical analysis, this paper establishes the econometric model and tries to explore the influence of different factors on enterprise innovation in different regions.
A BOUNDARY AWARE NEURAL NETWORK FOR ROAD EXTRACTION FROM HIGH-RESOLUTION REMOTE SENSING IMAGERY

Abstract. Automatic road extraction from high-resolution remote sensing imagery has various applications like urban planning and automatic navigation. Existing methods for automatic road extraction however, focus on regional accuracy but not on the boundary quality. To address this problem, a Boundary-aware Road extraction Network (BARoadNet) is proposed. BARoadNet is a coarse-to-fine architecture composed of two encoder-to-decoder networks, a Coarse Map Predicting Module (CMPM) and Fine Map Predicting Module (FMPM). The CMPM learns to predict coarse road segmentation maps. The FMPM is used to refine the coarse road maps by learning the difference between the coarse road extraction result and the ground truth. Experiments are conducted on the open Massachusetts Road Dataset. Quantitative and qualitative analysis demonstrate that the proposed BARoadNet can improve the quality and accuracy of road extraction results compared with the state-of-the-art methods.
That IS a high-end convertible : polarity focus , contrastive focus , answer focus , givenness *

Polarity focus has rarely if ever been considered by researchers pursuing a general, unified theory of focus. I argue that an examination of polarity focus data pushes us to resolve several challenging topics central to the semantics and pragmatics of focus: truly contrastive focus and its relationship to answer focus, obligatory vs. optional focus and the mechanism that enforces focus marking (maximize presupposition), the relationship between contextually salient antecedents and evoked or accommodated antecedents, and the role of givenness deaccenting. I propose a theory of focus that, building on Katzir 2013, makes use of the notion of innocent exclusion from Fox 2007. But it also builds on Wagner 2006, 2012b and Büring 2016c, 2019 by taking focus to impose a true contrast requirement on antecedents, stricter than classically assumed. I also present new evidence for a distinct givenness deaccenting requirement, and show how a general theory of focus applied to polarity focus enables a pragmatic explanation of the inference that verum/polarity focus emphasizes the truth of an utterance. The paper ends with a comparison to previous accounts of verum/polarity focus, pointing out challenges for VERUM operator approaches.
Two monotone stochastic orders based on tail comparisons

Actuarial risks and nancial asset returns are tipically heavy tailed. In this paper, we introduce two criteria, called the right tail order and the left tail order, to compare stochastically these variables. The criteria are based on comparisons of expected utilities, for two classes of utility functions that give more weight to the right or the left tail (depending on the context) of the distributions. We study their properties, applications and connections with other classical orders, including the increasing convex and increasing concave orders. Finally, we provide empirical evidence of these orders with an example using real data.
Government Compliance with Public Procurement Policy and Performance of Construction Enterprises in Cameroon: A Micro Panel Modelling Approach

This paper aimed to investigate the implication of government compliance with public procurement policy for the performance of enterprises operating in the construction sector in Cameroon. To achieve its objectives, the paper made use of a micro panel collected with the help of structured questionnaires. The Pooled OLS and the random versus fixed effects models were used for the analyses. Findings revealed that the contract winning rate of construction enterprises increases monotonically over the period under study. While the performance of construction enterprises stagnated over the period 2013-2016, it only witnessed a drop in 2017 and 2018. The pooled OLS and the Random effect regression results revealed that government compliance with payment duration of construction enterprises’ bills positively and significantly affects the performance of construction enterprises in Cameroon. Based on these findings, the study recommends that the government could consider redressing the policies on the regular and prompt payment of enterprises’ bills within the timeline specified in the contracts to enable them meet up with their financial requirements, thereby contributing to their overall performance.
Karakterisasi dari Properti Larutan Garam dengan Range Finder Ultrasonik Menggunakan Metode Transformasi Fourier

In this paper we characterize the saline solution using Range Finder Ultrasonic (RFU). RFU is one kind of ultrasonic transducer that requires air as a transmission medium and commonly are used to determine distances. The advantages of this transducer are cheap and common in local market. Since it uses air as medium, the signal which is produced by transducer are easy to shape shift and has a very long noise tail wave. This phenomenon was seen in previous studies, when the transducer position was slightly shifted, the shape of the echo signal became very different. In this paper, we modified the input signal from the technique in the previous paper to improve the echo signal. Some modification of trigger signal from transmitter models were done, then calculate the echo signal to ensure the signal have smallest Signal to Noise Ratio (SNR) and noise tail wave. Furthermore, we did filtering process from echo signal and calculating using Fourier Transform which are performed to obtain accurate echo signal information of 40 KHz frequency. The results of this experiment is an improvement in the average error of calibration curve 0.1224221 (Vrms) and 0.14383881 (Vpeak). While the average error of the results of the normalization of the magnitude Fourier Transform of 40 KHz frequency is equal to 0.096973114.
First molecular and serological detection of Epizootic Hemorrhagic Disease virus in white tailed deer (Odocoileus virginianus) from Tamaulipas, Mexico

Epizootic hemorrhagic disease viruses (EHDV) are dsRNA arboviruses transmitted by biting midges of the genus Culicoides that cause disease in domestic and wild ruminants. Epizootic hemorrhagic disease (EHD) is considered the most important infectious disease of white tailed deer (WTD) in North America, some studies in Northeast Mexico reported EHDV-seropositive WTD and EHDV-infected Culicoides vectors. The increasing population of WTD that share habitat with livestock in Northeast México highlights the importance of EHD for the livestock industry in the transboundary region with the U.S. One hundred and twenty two samples from WTD in Tamaulipas state, Mexico were tested by ELISA and RT-PCR for EHDV antibodies and nucleic acid, respectively. Twelve animals were seropositive to ELISA and eleven animals were positive by RT-PCR. This is the first report of EHDV nucleic acid detection in WTD from Mexico. It is hypothesized that applying the transboundary disease approach to interdisciplinary research will help fill knowledge gaps, which could help develop countermeasures to mitigate the threat of EHDV infection in wildlife and livestock along the U.S.-Mexico border.