Miracle-dz/UniFAR-FTUs huggingface dataset:
First Study on Nihonium (Nh, Element 113) Chemistry at TASCA

Nihonium (Nh, element 113) and flerovium (Fl, element 114) are the first superheavy elements in which the 7p shell is occupied. High volatility and inertness were predicted for Fl due to the strong relativistic stabilization of the closed 7p 1/2 sub-shell, which originates from a large spin-orbit splitting between the 7p 1/2 and 7p 3/2 orbitals. One unpaired electron in the outermost 7p 1/2 sub-shell in Nh is expected to give rise to a higher chemical reactivity. Theoretical predictions of Nh reactivity are discussed, along with results of the first experimental attempts to study Nh chemistry in the gas phase. The experimental observations verify a higher chemical reactivity of Nh atoms compared to its neighbor Fl and call for the development of advanced setups. First tests of a newly developed detection device miniCOMPACT with highly reactive Fr isotopes assure that effective chemical studies of Nh are within reach.
Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial

Animal evidence indicates that green tea may modulate insulin sensitivity, with epigallocatechin-3-gallate (EGCG) proposed as a likely health-promoting component. The purpose of this study was to investigate the effect of dietary supplementation with EGCG on insulin resistance and associated metabolic risk factors in man. Overweight or obese male subjects, aged 40–65 years, were randomly assigned to take 400 mg capsules of EGCG (n 46) or the placebo lactose (n 42), twice daily for 8 weeks. Oral glucose tolerance testing and measurement of metabolic risk factors (BMI, waist circumference, percentage body fat, blood pressure, total cholesterol, LDL-cholesterol, HDL-cholesterol, TAG) was conducted pre- and post-intervention. Mood was evaluated weekly using the University of Wales Institute of Science and Technology mood adjective checklist. EGCG treatment had no effect on insulin sensitivity, insulin secretion or glucose tolerance but did reduce diastolic blood pressure (mean change: placebo − 0·058 (se 0·75) mmHg; EGCG − 2·68 (se 0·72) mmHg; P = 0·014). No significant change in the other metabolic risk factors was observed. The EGCG group also reported feeling in a more positive mood than the placebo group across the intervention period (mean score for hedonic tone: EGCG, 29·11 (se 0·44); placebo, 27·84 (se 0·46); P = 0·048). In conclusion, regular intake of EGCG had no effect on insulin resistance but did result in a modest reduction in diastolic blood pressure. This antihypertensive effect may contribute to some of the cardiovascular benefits associated with habitual green tea consumption. EGCG treatment also had a positive effect on mood. Further studies are needed to confirm the findings and investigate their mechanistic basis.
Body weight in parous women: Is there any alteration between successive pregnancies?

Abstract. In 50 women who had five successive pregnancies the difference was studied between the mean maternal weight at the 20th week of gestation and six weeks post partum. The difference changed from a weight loss to a weight gain in the fourth and fifth pregnancies. The maximum weight increment occurred between the end of the first pregnancy and the 20th week of the second, especially in obese multiparae.
Effect of carvacrol on tracheal responsiveness, inflammatory mediators, total and differential WBC count in blood of sensitized guinea pigs

The effects of carvacrol on tracheal responsiveness (TR) to methacholine and ovalbumin (OA), serum nitric oxide (NO) concentration, total and differential white blood cells (WBC) in blood of sensitized guinea pigs were examined. Five groups of guinea pigs sensitized to OA were given drinking water alone (group S), drinking water containing three concentrations of carvacrol (40, 80 and 160 μg/mL) and dexamethasone (50 μg/mL). TR to methacholine and OA, serum NO concentration, total and differential WBC in blood of sensitized and control guinea pigs were measured (n = 6, for each group). TR to methacholine and OA, serum level of NO and nitrite, total WBC, eosinophil and neutrophil counts were increased but lymphocyte decreased in group S compared with control group (P < 0.01 for NO and nitrite and P < 0.001 for other cases). Treatment of S animals with dexamethasone and two higher concentrations of carvacrol significantly improved all measured parameters except TR to OA in treated group with dexamethasone (P < 0.05 to P < 0.001). Treatment of S animals with low concentration of carvacrol also improved TR to methacholine and OA, total WBC count and nitrite level (P < 0.05 to P < 0.001). The effects of two higher concentrations of carvacrol on TR, NO and nitrite and the effects of its highest concentration on total and differential WBC count were significantly higher than those of dexamethasone (P < 0.05 to P < 0.001). In addition, the effects of highest concentration of carvacrol on all parameters and its medium concentration on some parameters were significantly higher than its low concentration (P < 0.05 to P < 0.001). These results showed a preventive effect of carvacrol on tracheal responsiveness, serum level of NO and nitrite, total and differential WBC in the blood of sensitized guinea pigs which was equal or even more potent than dexamethasone at used concentrations.
Gender differences in anaerobic power of the arms and legs--a scaling issue.

PURPOSE Physiological variables must be scaled for body size differences to permit meaningful comparisons between groups. Using allometric scaling, this study compared the anaerobic performance, using both arms and legs, of men and women. Ten active male and 10 active female subjects performed the leg cycling and arm cranking in a 30-s all-out Wingate test (WAnT). Regional measurements of the legs, gluteal area, arms, and torso taken using dual-energy x-ray absorptiometry (DXA) served as indicators of lower body active musculature (LBAMM) and upper body (UBAMM) active musculature. RESULTS Body mass (BM) was the best predictor (i.e., r = 0.93-0.96) for peak power (PP) and mean power (MP) generated from sprint cycling and arm cranking. Sex differences for leg and arm power (i.e., PP and MP) were identified in absolute terms and then expressed in ratio to BM(1.0). When the same data were allometrically scaled to BM and expressed as power function ratios (Power;BM(b)), the sex differences in PP and MP for sprint cycling were nullified (female:male ratio x 100: 100-103%), but remained for arm cranking (female:male power ratio x 100: 69-84%). CONCLUSIONS These results confirmed that anaerobic power of the upper body and lower body were best normalized to BM and, when statistically appropriate methods were used to take into account differences in BM, PP, and MP generated from sprint cycling were similar for both men and women. In contrast, after allometric scaling for BM, men remained more powerful than women for the supramaximal arm cranking task. Qualitative differences in the upper body musculature between men and women are speculated to account for the more powerful performance of men, but confirmatory evidence using noninvasive techniques is warranted.
Alcohol Consumption and Breast Cancer Risk Among Postmenopausal Women Following the Cessation of Hormone Therapy Use: The California Teachers Study

Background: Alcohol consumption increases breast cancer risk, but its effect may be modified by hormone therapy (HT) use, such that exposure to both may be synergistic. Because many women stopped taking HT after mid-2002, it is important to quantify risks associated with alcohol consumption in the context of HT cessation, as these risks may be more relevant to cancer prevention efforts today. Methods: Among 40,680 eligible postmenopausal California Teachers Study cohort participants, 660 were diagnosed with invasive breast cancer before 2010. Multivariate Cox proportional hazards regression models were used to estimate relative risks (RR) and 95% confidence intervals (CI). Results: Increased breast cancer risk associated with alcohol consumption was observed among postmenopausal women who were current HT users [RR, 1.60; 95% confidence interval (CI), 1.13–2.26 and RR, 2.11; 95% CI, 1.41–3.15 for <20 and ≥20 g/d of alcohol], with risks being similar by HT preparation. Alcohol did not increase risk among women who had stopped using HT within 3 years or 3 to 4 years before completing the follow-up questionnaire or in the more distant past. Results were similar for estrogen receptor positive (ER+) and ER+PR+ progesterone receptors positive (PR+) tumors; while power was limited, no increase in risk was observed for ER− tumors. Conclusions: Following the cessation of HT use, alcohol consumption is not significantly associated with breast cancer risk, although a nonsignificant increased risk was observed among women who never used HT. Impact: Our findings confirm that concurrent exposure to HT and alcohol has a substantial adverse impact on breast cancer risk. However, after HT cessation, this risk is reduced. Cancer Epidemiol Biomarkers Prev; 21(11); 2006–13. ©2012 AACR.
Treatment of gastric precancerous lesions with Weiansan.

AIM To observe the curative effect of Weiansan (WAS) on gastric precancerous lesions (GPL) and H pylori elimination. METHODS Seventy-six patients with GPL were randomly divided into two groups: WAS group (n = 42) and Weifuchun (WFC) group (n = 34). The patients in the WAS group were administered 5 g WAS 3 times a day, and the patients in the WFC group took WFC (4 tablets) 3 times a day. To monitor inflammation of gastric mucosa, degree of glandular atrophy (GA), intestinal metaplasia (IM) and dysplasia, and H pylori infection, all patients underwent gastroscopy and biopsy with pathological examination before and after treatment. Fifty male Sprague-Dawley (SD) rats were used in animal experiments. Of these, 10 served as the control group (n = 10), 40 were given ranitidine combined with N-methyl-N(1)-nitro-N-nitrosoguanidine (MNNG) for 12 wk and divided into 4 groups randomly: model group (n = 10), high-dose WAS group (n = 10), low-dose WAS group (n = 10) and WFC group (n = 10). Twelve weeks later, all rats were killed and a 2 cm multiply 1 cm tissue was taken from the lesser curvature of the gastric antrum. H pylori infection was determined by the fast urease method. RESULTS The curative effect in WAS groups was similar to that in WFC groups. There was no statistical difference in degree of GA, IM and dysplasia between WAS and WFC groups. The rate of H pylori infection in the model group (positive/negative: 9/1) was significantly higher than that in the control group (positive/negative: 1/9) (P < 0.01). H pylori elimination in the high-dose WAS group (positive/negative: 4/6) and low-dose WAS group (positive/negative: 6/4) was similar to that in the WFC group (positive/negative: 4/6) (P > 0.05). CONCLUSION WAS improves clinical symptoms by suppressing GA, IM and dysplasia and eliminating H pylori.
Projection neurons originating from thermo‐ and hygrosensory glomeruli in the antennal lobe of the cockroach

Most insects are equipped with specialized thermo‐ and hygroreceptors to locate a permissible range of ambient temperature and distant water sources, respectively. In the cockroach, Periplaneta americana, cold, moist, and dry receptor cells in the antennae send axons to particular sets of two or three glomeruli in the dorsocentral part of the antennal lobe (primary olfactory center), designated DC1–3 glomeruli. However, it is not known how thermo‐ and hygrosensory signals from these glomeruli are represented in higher‐order centers, the protocerebrum, in any insect species. With the use of intracellular recording and staining techniques, we identified a new class of interneurons with dendrites almost exclusively in the DC1, DC2, or DC3 glomeruli and axons projecting to the protocerebrum in the cockroach. Remarkably, terminals of all these projection neurons (PNs) covered almost identical areas in the lateral protocerebrum (LP), although their termination areas outside the LP differed from neuron to neuron. The termination areas within the LP were distinct from, but close to, those of uniglomerular and macroglomerular PNs that transmitted signals concerning general odors and female sex pheromones, respectively. PNs originating from DC1, DC2, and DC3 glomeruli exhibited excitatory responses to cold, moist, and dry stimuli, respectively, probably due to excitatory synaptic input from cold, moist, and dry receptor cells, respectively, whereas their responses were often modulated by olfactory stimuli. These findings suggested that dorsocentral PNs participate in neural pathways that lead to behavioral responses to temperature or humidity changes. J. Comp. Neurol. 455:40–55, 2003. © 2002 Wiley‐Liss, Inc.
Excimer laser with adjunctive balloon angioplasty and heparin-coated self-expanding stent grafts for the treatment of femoropopliteal artery in-stent restenosis: twelve-month results from the SALVAGE study.

OBJECTIVES The aim of the study is to evaluate the safety and effectiveness of treating femoropopliteal in-stent restenosis (ISR) with debulking with excimer laser followed by implantation of a VIABAHN endoprosthesis. BACKGROUND The optimal treatment strategy for femoropopliteal ISR is unclear. METHODS The SALVAGE study is a multicenter prospective registry involving nine US centers. Patients with femoropopliteal ISR with moderate to severe intermittent claudication or critical limb ischemia (Rutherford categories 2-5) and an ankle-brachial index (ABI) =0.8 were treated with excimer laser and the VIABAHN endoprosthesis. The primary efficacy endpoint is primary patency at 12 months as measured by duplex ultrasonography. The primary safety endpoint is the major adverse event (MAE) rate at 30 days. RESULTS Twenty-seven patients were enrolled. The mean lesion length was 20.7 ± 10.3 cm. The majority of lesions were TASC (TASC I) C and D (81.4%). All lesions were pretreated with excimer laser and percutaneous transluminal angioplasty (PTA) prior to VIABAHN implantation. Technical success was achieved in 100% of cases. There were no MAE at 30 days. Primary patency at 12 months was 48%. The ankle brachial index increased from 0.58 ± 0.24 at baseline to 0.90 ± 0.17 at 12 months. There was improvement in all quality-of-life parameters. The 12-month TLR rate was 17.4%. CONCLUSIONS The strategy of excimer laser atherectomy and PTA followed by implantation of a self-expanding stent graft for the treatment of femoropopliteal ISR is safe and associated with high procedural success. Primary patency rate at 12-months was suboptimal; however, the TLR rate was low.
Role of sensory‐motor cortex activity in postnatal development of corticospinal axon terminals in the cat

The initial pattern of corticospinal (CS) terminations, as axons grow into the spinal gray matter, bares little resemblance to the pattern later in development and in maturity. This is because of extensive axon pruning and local axon terminal growth during early postnatal development. Pruning is driven by activity‐dependent competition between the CS systems on each side during postnatal weeks (PW) 3–7. It is not known whether CS axon terminal growth and final topography are activity dependent. We examined the activity dependence of CS axon terminal growth and topography at different postnatal times. We inactivated sensory‐motor cortex by infusion of the γ‐aminobutyric acid type A (GABAA) agonist muscimol and traced CS axons from the inactivated side. Inactivation between PW5 and PW7 produced permanent changes in projection topography, reduced local axon branching, and prevented development of dense clusters of presynaptic sites, which are normally characteristic of CS terminals. Inactivation at younger (PW3–5) and older (PW8–12) ages did not affect projection topography but impeded development of local axon branching and presynaptic site clusters. These effects were not due to increased cortical cell death during inactivation. Neural activity plays an important role in determining the morphology of CS terminals during the entire period of development, but, for the projection topography, the role of activity is exercised during a very brief period. This points to a complex, and possibly independent, regulation of termination topography and terminal morphology. Surprisingly, when a CS neuron's activity is blocked during early development, it does not recover lost connections later in development once activity resumes. J. Comp. Neurol. 485:43–56, 2005. © 2005 Wiley‐Liss, Inc.
Exploring the development of Irish pre-service science teachers’ scientific inquiry orientations using a pedagogical content knowledge lens within a targeted learning community

cannot understand that everything is made up of matter. Cannot picture this in their head. Trying to understand the wordsmatter and mass. Would confuse the meaning of with colloquial meaning. Hard to understand compression, because even though a solid cannot be compressed, you can compress a ball. Existing misconceptions. Should not follow the book directly as the layout can be confusing. Misconceptions that stem from the textbook. Advanced English. Students asking questions that were beyond the scope of the information needed. Content knowledge of the teacher Visualisation of the structure.  Difficult terminology The word sublimation is hard to understand and there is not an example every-day. Hard to explain diffusion in a scientific way. It would be difficult for students to put things into their own words. Knowledge of students thinking which influences your teaching of this idea They will be thinking things like does everything have mass. Cannot see gas, so how can you weigh it. Does not really take up space because you can fit so much around it. How can there be gaps between gas particles since there are carbon dioxide and oxygen in the air. Gases all react with each other and are joined so they must be joined together. They will be thinking “I can’t see the structure of this. How do you know it looks like this”? It’s very abstract. Students understanding the process of changing state.
Cloning and characterization of an acyl-CoA-dependent diacylglycerol acyltransferase 1 (DGAT1) gene from Tropaeolum majus, and a study of the functional motifs of the DGAT protein using site-directed mutagenesis to modify enzyme activity and oil content.

SUMMARY A full-length cDNA encoding a putative diacylglycerol acyltransferase 1 (DGAT1, EC 2.3.1.20) was obtained from Tropaeolum majus (garden nasturtium). The 1557-bp open reading frame of this cDNA, designated TmDGAT1, encodes a protein of 518 amino acids showing high homology to other plant DGAT1s. The TmDGAT1 gene was expressed exclusively in developing seeds. Expression of recombinant TmDGAT1 in the yeast H1246MATalpha quadruple mutant (DGA1, LRO1, ARE1, ARE2) restored the capability of the mutant host to produce triacylglycerols (TAGs). The recombinant TmDGAT1 protein was capable of utilizing a range of (14)C-labelled fatty acyl-CoA donors and diacylglycerol acceptors, and could synthesize (14)C-trierucin. Collectively, these findings confirm that the TmDGAT1 gene encodes an acyl-CoA-dependent DGAT1. In plant transformation studies, seed-specific expression of TmDGAT1 was able to complement the low TAG/unusual fatty acid phenotype of the Arabidopsis AS11 (DGAT1) mutant. Over-expression of TmDGAT1 in wild-type Arabidopsis and high-erucic-acid rapeseed (HEAR) and canola Brassica napus resulted in an increase in oil content (3.5%-10% on a dry weight basis, or a net increase of 11%-30%). Site-directed mutagenesis was conducted on six putative functional regions/motifs of the TmDGAT1 enzyme. Mutagenesis of a serine residue in a putative SnRK1 target site resulted in a 38%-80% increase in DGAT1 activity, and over-expression of the mutated TmDGAT1 in Arabidopsis resulted in a 20%-50% increase in oil content on a per seed basis. Thus, alteration of this putative serine/threonine protein kinase site can be exploited to enhance DGAT1 activity, and expression of mutated DGAT1 can be used to enhance oil content.
Reference values for change in body mass index from birth to 18 years of age

Body mass index (BMI) has become the measure of choice for determination of nutritional status during the paediatric years, as in adults. Recently, several cross‐sectional BMI childhood reference values standards have been published. In order precisely to evaluate childhood nutritional interventions, reference values allowing for the evaluation of changes in BMI values are also needed. For the first time, such reference values can be presented based on 3650 longitudinally followed healthy Swedish children born full term. The reference values for the change in BMI are given as the change in BMI standard deviation scores. The reference values are given as means of mathematical functions adjusting for gender, age of the child and the length of the interval between two measurements for interval lengths of 0.25 to 1.0 y before 2y of age and of 1 to 5 y between birth and 18 y. The usefulness of the reference values is proved by a graph that forms a part of a clinical computer program; the ‐2 to +2 standard deviation range of the predicted change in BMI can be computed for an individual child and drawn in the graph as an extended support for clinical decision‐making.
Comparative Accounting – Is It Still Relevant in Today’s Global Era of Convergence?

This essay discusses the relevance of comparative accounting in the midst of convergence efforts championed by the international accounting standard setter – the International Accounting Standards Board (IASB). Obstacles to comparability in reference to respective countries’ various attributes, namely the regulatory regime and capital market are discussed. In addition, other specific factors such as business and financial environments as well as accounting and auditing culture are also discussed. The essay concludes that although the process of convergence is swiftly taking place worldwide, comparative accounting still remains an important topic to address within all international accounting subjects.
Distribution of the Rad51 recombinase in human and mouse spermatocytes

In vitro, the human Rad51 protein (hRad51) promotes homologous pairing and strand exchange reactions suggestive of a key role in genetic recombination. To analyse its role in this process, polyclonal antibodies raised against hRad51 were used to study the distribution of Rad51 in human and mouse spermatocytes during meiosis I. In human spermatocytes, hRad51 was found to form discrete nuclear foci from early zygotene to late pachytene. The foci always co‐localized with lateral element proteins, components of the synaptonemal complex (SC). During zygotene, the largest foci were present in regions undergoing synapsis, suggesting that Rad51 is a component of early recombination nodules. Pachytene nuclei showed a greatly reduced level of Rad51 labelling, with the exceptions of any asynapsed autosomes and XY segments, which were intensely labelled. The distribution of Rad51 in mouse spermatocytes was similar to that found in human spermatocytes, except that in this case Rad51 was detectable at leptotene. From these results, we conclude that the Rad51 protein has a role in the interhomologue interactions that occur during meiotic recombination. These interactions are spatially and temporally associated with synapsis during meiotic prophase I.