Miracle-dz/UniFAR-FTUs huggingface dataset:
The Technique in the Treatment of Cancer Uteri at Radiumhemmet

In Sweden the treatment of cancer uteri by local application of ra­ dium salt was started by FORSSELL in 1910. The quantities of radium that FORSSELL had at his disposal during the first few years were in the light of modern conception extremely modest. Ten to fifteen, rarely twenty milligram radium element, (mg. Ra. el.) was the quantity generally used in the treatment of a case of cancer of the collum of the uterus. The filter usually employed was 0.5—1.5 mm silver. The time of application rarely exceeded 20 hours. In cases of favourable progress the treatment was repeated a number of times, even up to ten, at intervals of three to six weeks. I t was a treatment, therefore, with oft repeated small doses, frequently extended over a very long period, a technique as indicated by WICKHAM (Lazarus' Handbuch der Therapie 1913). As soon as permitted by the radium quantities available FORSSELL adopted a technique of treatment the first phase of which, »la méthode du rayonnement ultrapénétrant» (DOMINICI), consisted in a more huavy filtration and the second phase of which, »la méthode des doses massives» (CHÉRON and DUVAL), consisted in the employment of larger quantities of radium. During the years 1912 and 1913 FORSSELL worked with gra­ dually increasing quantities of radium and with a filter of 2, 3 or 4 mm lead. At the same time the number of treatments were more and more reduced and the interval between the different applications shortened. In a series of cases FORSSELL was able to show that these changes in the
Endothelial dysfunction in the peri-operative setting

To provide a brief synopsis of endothelial (dys)function. To explore the pathophysiology of endothelial dysfunction in the perioperative period. To explore strategies for modulation of endothelial function. While peri-operative macrovascular events (e.g. myocardial infarction, stroke, etc) are readily evident, their absolute incidence remains relatively low. In contrast, microvascular dysfunction and its role in peri-operative morbidity is not readily appreciated nor easily measured. Given the ubiquitous presence of endothelium in all organs, microvascular dysfunction is likely to have a greater impact, through impaired perfusion, on non-cardiovascular complications (e.g. wound healing and end organ failure) than that which is readily appreciated.
Les recherches sur la biologie moléculaire du virus de la varicelle et du zona (VZV) ont-elles des applications cliniques ?

RAPPELS LA VARICELLE La varicelle est l'infection primaire par le virus de la varicelle et du zona (1). Elle debute par l'infection de la conjonctive ou des muqueuses respiratoires superieures et a ce titre, le VZV peut etre considere comme un virus respiratoire. Le virus se replique dans les ganglions lymphatiques proches de sa porte d'entree. Apres environ 5 jours, une viremie primaire a lieu et le virus se replique dans un certain nombre d'organes qui ne sont pas tous parfaitement identifies (le foie, la rate). Il effectue une viremie secondaire avant d'atteindre la peau ou il se multiplie apres environ 2 semaines. C'est alors qu'apparait l'eruption vesiculeuse tout a fait caracteristique. C'est egalement a ce moment que le virus penetre dans le systeme nerveux et accede aux ganglions sensoriels ou il va resider pour toute la duree de l'existence. TABLEAU I. — La reactivation du zona. Nombre de recurrences VZV Une seule HSV Jusqu'a plusieurs centaines Probabilite de reactivation ↗ avec l'âge ↘ avec l'âge P. 100 de seropositifs avec recurrences symptomatiques 10-20 p. 100 20-47 p. 100
MULTIFACTORIAL ANALYSIS OF DIETARY PATTERNS IN HEALTHY AND CORONARY ARTERY DISEASE PATIENTS: BRIEF REPORT

Background: The effects of consumption of nutrients on coronary artery disease (CAD) are widely observed. The aim of this study is to assess the exclusive Iranian dietary pattern on coronary artery diseases (CAD) and its risk factors. Methods: In this description-cross sectional study, 801 inhabitants of Borujerd City were included by random stratification method and a questionnaire regarding micro-and macronutrients for subjects over 35 years old from March 2011 to February 2012 was filed out. Of all the subjects consent to participate were prepared by volunteers. The complete description and a standard questionnaire to record demographic and so-cioeconomic status of people were taken. The prevalence of coronary artery disease and its risk factors determined Based on rose questionnaire and Monica questionnaire re-spectively. Results: In this study mean age of the subjects were 54.8±1.2 years, 388 male and 413 female. There was no meaningful relation between red meat consumption and coronary artery disease (P= 0.117). Nut consumption was higher in patients with CAD (P= 0.028). Use of fresh and cooked vegetables, dried fruit, animal oils cakes, french fries and some dairies are correlated with CAD (P< 0.05). However, artificially flavored soda in contrast to ordinary soda was not associated with coronary artery disease. Conclusion: Although there are some differences between dietary pattern in patient with coronary artery disease, nutritional attitudes are not significantly different in nor-mal and CAD patients. However, according to the importance of diet in CAD, balanc-ing these attitudes should be on the educational system high priority. Abstract
An overview and some recent advances in statistical methods for population-based cancer survival analysis

Long-term survival rates are the most commonly used outcome measures for patients with cancer. However, traditional longterm survival statistics, which are derived by cohort-based types of analysis, essentially reflect the survival expectations of patients diagnosed many years ago. They are therefore often severely outdated at the time they become available. A couple of years ago, a new method of survival analysis, denoted period analysis, has been introduced to derive more ‘up-to-date’ estimates of long-term survival rates. We give a comprehensive review of the new methodology, its statistical background, empirical evaluation, computational realisation and applications. We conclude that period analysis is a powerful tool to provide more ‘up-to-date’ cancer survival rates. More widespread use by cancer registries should help to increase the use of cancer survival statistics for patients, clinicians, and public health authorities. # 2003 Elsevier Ltd. All rights reserved.
A phase II safety study of bevacizumab in patients with multiple recurrent or progressive malignant gliomas

2079 Introduction: Available treatment options for patients with recurrent MG are few. Recent trends have used target specific agents but none has been effective to date. A single agent trial was designed to determine the safety and efficacy of bevacizumab in patients with recurrent MG. Recently, bevacizumab and CPT-11 in combination have shown response rates of approximately 60%. Patients and Methods: All patients (pts) had to sign an IRB informed consent. All pts had to have at least two relapses. Pts had to be > 18 year of age with Karnofsky performance status of > 60. Adequate bone marrow, liver and renal function was required, as well as normal urine protein and creatinine. Patients were required to be on a non-enzyme inducing anti-convulsants. An MRI with perfusion was done at baseline (if patient consented) and then every 6 weeks. Patients continued on trial as long as they did not have tumor progression. Patients received bevacizumab 15 mg/kg every 3 weeks as a 60–90 minute infusion. Results: To d.
Learning analytics in primary , secondary and higher education

Purpose – The purpose of this paper is to draw attention to the potential of “small data” to complement research in learning analytics (LA) and to share some of the insights learned from this approach. Design/methodology/approach – This study demonstrates an approach inspired by design science research, making a dashboard available to n1⁄4 1,905 students in 11 study programs (used by n1⁄4 887) to learn how it is being used and to gather student feedback. Findings – Students react positively to the LA dashboard, but usage and feedback differ depending on study success. Research limitations/implications – More research is needed to explore the expectations of a high-performing student with regards to LA dashboards. Originality/value – This publication demonstrates how a small data approach to LA contributes to building a better understanding.
Tetrahydrocannabinol in the treatment of neuropsychiatric symptoms in dementia

This systematic review aims to integrate the evidence on indications, efficacy, safety and pharmacokinetics of medical cannabinoids in older subjects. The literature search was conducted using PubMed, EMBASE, CINAHL and Cochrane Library. We selected controlled trials including solely older subjects (≥ 65 years) or reporting data on older subgroups. 105 (74%) papers on controlled intervention trials, reported the inclusion of older subjects. Five studies reported data on older persons separately. These were randomized controlled trials, including in total 267 participants (mean age 47-78 years). Interventions were oral tetrahydrocannabinol (THC) (n=3) and oral THC combined with cannabidiol (n=2). The studies showed no efficacy on dyskinesia, breathlessness and chemotherapy induced nausea and vomiting. Two studies showed that THC might be useful in treatment of anorexia and behavioral symptoms in dementia. Adverse events were more common during cannabinoid treatment compared to the control treatment, and were most frequently sedation like symptoms. Although trials studying medical cannabinoids included older subjects, there is a lack of evidence of its use specifically in older patients. Adequately powered trials are needed to assess the efficacy and safety of cannabinoids in older subjects, as the potential symptomatic benefit is especially attractive in this age group.
Riding the Post Earnings Announcement Drift: Evidence from Mutual Funds

This paper uses portfolio holdings and returns of mutual funds to study whether investors can profitably trade on the post earnings announcement drift (PEAD). We find that actively-managed US equity mutual funds on average trade on PEAD, even after controlling for different investment styles and momentum trading. Further, trading on PEAD is profitable: net of both transaction costs and fund expenses, the annual Carhart (1997) four-factor alpha of the top 10% of funds most actively following the PEAD strategy is 2.10% higher than that of a group of benchmark funds not actively using the strategy. However, across funds, more active trading on PEAD is associated with less portfolio diversification, higher volatility in fund returns and higher volatility in fund flows, representing adverse consequences of arbitrage risk. Finally, we document the temporal dynamics between fund trading and the profitability of the PEAD strategy: higher profitability attracts more intense trading by funds, which, in turn, leads to lower future profitability.
HYPERTENSIVE STATES IN PREGNANCY

DISCUSSION of hypertensivestates in pregnancycannot proceed satisfactorily without an attempt at classification of those states, confusing and overlapping as they often are. The grouping adopted by the American Committee on Maternal Welfare in 1940 can be used here, and could well be generally used in all large clinics and by workers in this field. As Dieckmann'" has pointed out, final classification may have to await follow-up of the patients.
External Fake Constraints Interpolation: the end of Runge phenomenon with high degree polynomials relying on equispaced nodes – Application to aerial robotics motion planning

The present paper introduces a new approximation method that suppresses the Runge phenomenon with high degree polynomials relying on equispaced nodes. The principle consists in using external constraints of the type P”(x)=0 externally to the interpolation interval. As those constraints do not have any validity regarding the Runge function behavior we call them External Fake Constraints (EFC). We demonstrate that the EFC method can be of greater accuracy than Spline interpolation. We then apply the EFC principle to a simple aerial robotics motion planning problem and demonstrate the interest for linear system optimization under kinematics constraints and present the associated results. We then open the door to directions to improve and formalize EFC method and propose other applications in aerial robotics motion planning.
Empirical study on Fuel Consumption of Paratransit in Jakarta city

Assistant Professor, Graduate School for International Development and Cooperation, Hiroshima University (Kagamiyama, 1-5-1, Higashi Hiroshima, Japan) Email: sbntotok@hiroshima-u.ac. jp Professor, Graduate School for International Development and Cooperation, Hiroshima University (Kagamiyama, 1-5-1, Higashi Hiroshima, Japan) Email: afujiw@hiroshima-u.ac. jp Associate Professor, Graduate School for International Development and Cooperation, Hiroshima University (Kagamiyama, 1-5-1, Higashi Hiroshima, Japan) Email: zjy@hiroshima-u.ac. jp
The Epidemiology of Psychiatric Disorders in Children and Adolescents in Mazandaran Province

1.Alzahra University, Tehran, I.R. Iran 2.Psychiatry and Psychology Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran 3.Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, I.R. Iran 4.Allameh Tabatabei University, Tehran, I.R. Iran 5.Islamic Azad University, Sari Branch, Sari, I.R. Iran 6.Shahid Beheshti University, Tehran, I.R. Iran 7.Islamic Azad University, Roudehen Branch, I.R. Iran 8.Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, I.R. Iran
Comparison of Markov Chain Monte Carlo and Generalized Least Square Methods on a Model of Glucose / Insulin Dynamics with GLP 1-DPP 4 Interaction

In this paper, the performances of Markov Chain Monte Carlo (MCMC) method and Generalized Least Square (GLS) method are compared when they are used to estimate the parameters in a nonlinear differential model of glucose/insulin metabolism with GLP1-DPP4 interaction. The model is used to generate the data that consists of the time-concentration measurements of plasma glucose and of insulin, which are important in Diabetes Mellitus (DM) treatment. We show the results from three different runs to obtain parameter estimations by both MCMC and GLS. The true values (TV), point estimates (PM), standard deviation (SD) and 95% credible intervals (CI) of population parameters based on the two methods are presented. Our results suggest that MCMC is better able to estimate the parameters based upon smaller bias and standard deviation. Although MCMC requires more calculation time than GLS, it offers a more appropriate method, in our opinion, for nonlinear model parameter estimations without knowledge of the distribution of the data and when heterogeneity of variance is evident. Keywords—glucose/insulin metabolism, GLS, MCMC, nonlinear differential equations model.
EFFECTS OF SUPPLEMENTATION OF TRIVALENT CHROMIUM AN D FATTY ACIDS ON CYTOKINES AND INSULIN-SIGNALING FACTORS IN ADIPO CYTES

INTRODUCTION In recent years, over nutrition has steadily increa sed due to refined diets. Over nutrition will induce ma ny nutrition-related diseases, one of which is obesity . It is well-established that inflammation is responsibl e for the pathogenesis of obesity-associated diseases , due to cytokine production by metabolic tissues and infiltrated immune cells . Obese patients had a high blood non-esterified fatty acid (NEFA) concentration . The high NEFA concentration could ABSTRACT Obese patients had a high blood non-esterified fatt y acid (NEFA) concentration. The high NEFA concentr ation could induce adipocytes to secrete pro-inflammatory cytokines, s uch as tumor necrosis factorα (TNF-α) and interleukin-6 (IL-6), which would inhibit insulin function and cause insulin re sistance. This study, therefore, was to investigate the effects of supplementation of trivalent chromium and fatty aci ds on non-esterified fatty acid (NEFA), pro-inflamm atory cytokines of IL-6, TNF-α and insulin-signaling factors in vitro. Differentiated mouse 3T3-L1 preadipocytes were ra ndomly divided into three groups: control, trivalent chromium (Cr group , Cr), trivalent chromium + fatty acids (Cr+FA grou p, CrFA). The added level of trivalent chromium was 50 μg/kg, fatty acids was 0.1 %. The NEFA level in the CrFA group had significantl y greater than that in the control group ( P< 0.05); however, the Cr group was significantly lo wer than the control ( P < 0.05). The levels of pro-inflammatory cytokines of IL-6 an d TNF-a in Cr group was significantly lower than in the control ( P< 0.05), in CrFA group was higher than in Cr group ( P< 0.05). The c-Jun N-terminal kinase (JNK) in CrFA group was low er than in the Cr and control groups ( P<0.05). In insulin-signaling factors, added trivalent chrom iu or fatty acids had no effect on IR (insulin receptor) expression. Added t rivalent chromium could increase t he expression of IRS-1 (insulin receptor substrate 1), PI3K-p85a and Akt significan tly (P< 0.05). However, in the CrFA group, the expression of IRS-1 and PI3K-p85a was reduced and increased the expression of Akt than that of the Cr and control groups ( P< 0.05). Thus, trivalent chromium with fatty acids supplementation has no gr eater efficiency than chromium only in cytokines an d i sulin-signaling factors.
Deception Detection in Online Media

Russian Federation and European Union are fighting againstfake news together with other countries in various topics. The disinform-ation affected British referendum of existing EU, the US election andCatalonia’s referendum are broadly studied. A need for automated fact-checking increases, European Commission’s Action Plan 8 is an evidence.In this work, we develop a model for detecting disinformation in Russianlanguage in online media. We use reliable and unreliable sources to com-pare named entities and verbs extracted using DeepPavlov library. Ourmethod shows four time greater recall compared to chosen baseline.
LEAKAGE IMMUNE SINGLE ENDED 8T SRAM CELL FOR ULTRA-LOW POWER MEMORY DESIGN

As the technology is advancing into deep submicron and as the size of the devices is scaled down, a number of issues are faced during the manufacturing of these computing devices. These critical issues include power consumption, size, and speed of electronic devices. Generally, the chip contains millions of transistors. Therefore, a lot of issues are associated with the working of these transistors among which, power dissipation is one of the important design concerns. In this paper, new low power 8T SRAM cell is proposed, which improves the leakage power, access time compared to 6T SRAM, 5T SRAM, and conventional 8T SRAM cell. Simulation and analytical results show that proposed 8T SRAM cell reduces leakage power by 83.54% compared to the conventional 8T cell, 73.27% compared to 6T SRAM cell and 86.1% compared to 5T SRAM cell. The access time of a new 8T cell is improved by 13.75% compared to 6T SRAM cell, 45.2% compared to conventional 8T SRAM cell and 49.20% compared to 5T SRAM cell. The proposed SRAM cell also reduces leakage current dramatically as compared to 6T SRAM cell, conventional 8T SRAM, and 5T SRAM cell
CORRELATION OF THE CURE DEGREE OF AN EPOXY RESIN WITH THE DIELECTRIC PROPERTIES

To minimize the waste and the production time during the fabrication of fibre reinforced plastics, online quality control is gaining importance. In the resin transfer moulding production the curing is the most time and cost consuming step. Therefore the part should be taken out of the mould as soon as it is dimensionally stable, which is reached at a certain degree of cure. Dielectric analysis (DEA) is one method to monitor the curing of the resin system. DEA measures the permittivity changes of the resin in a capacitor set-up while curing. After mixing the resin system consists of movable dipoles. During the curing process the molecules grow and form a network, what restricts the movement of the dipoles and changes the permittivity. For the correlation first the curing behaviour of the resin system was analysed by DSC measurements, then the degree of cure was modelled as a function of time. By using the rheometer plates as a capacitor for the DEA, the dielectric properties were measured simultaneously with the viscosity in a rheometer. Finally, the dielectric properties were analysed, considering the feasibility and sensitivity to cure, and a correlation regarding the degree of cure was obtained.
Morfometric evaluation of the crossbreed Holstein/Zebu cow placentome in the first, second and third trimester of pregnancy.

The aim of this study was to quantify the maternal cells and evaluate the volumetric proportions of structural components of crossbreed Holstein/Zebu cow placentome in the first, second and last tri- mester of pregnancy. For each trimester were used ten pregnant uteri, collected in slaughterhouse. The trimester of pregnancy was determinate using the crown-rump length. The placentomes were fixed in formol 10% and processed for histological examination. At the last trimester the maternal cells of the placentome decreased. The volumetric proportion of the fetal cells, binucleate cells, giant cells and vessels did not vary during gestation, while the volumetric proportion of the maternal cells and the fetal placentome conjunctive was lower at the first trimester of pregnancy. The maternal conjunctive tissue was higher in the last trimester of pregnancy. The results show that the number of maternal cells and the volumetric proportion of some structural components of the crossbreed Hols- tein/Zebu cow placentome change during pregnancy.
Dynamic Partial Reconfiguration of a Field Programmable Gate Array

The goal of this project was to develop a prototype of real‐time partial re‐configuration of a logic circuit. The steps required for completion involved researching possible circuit algorithms, implementing desired functionality in VHDL, and developing a proof of concept. The objective of this project was to lay a foundation for further development in implementing a self‐healing triple modular redundant AES encryption system. The project was completed under the guidance of Brendon Chetwynd and Gerardo Orlando of General Dynamics C4 Systems.
Frequency Domain Analyses of SEATS and X-11/12-ARIMA Seasonal Adjustment Filters for Short and Moderate-Length Time Series

We investigate frequency domain properties, revealed by the squared gain and phase delay functions, of short and moderate-length linear seasonal adjustment filters of the ARIMAmodel-based signal extraction method of SEATS. X-11/12-ARIMA filters are also considered to a limited extent. The focus is on the one-sided (concurrent) and symmetric (central) filters associated with the Box and Jenkins’s airline model for monthly time series of lengths 49 and 109. A Digital Signal Processing perspective on filter properties, favoring interpretability of the filter output, is presented. We show that important features of the finite filters actually used are often not visible in the diagnostics of the infinite filters, such as the Wiener-Kolmogorov symmetric filter gain functions provided by SEATS. For comparing competing adjustments, properties of concurrent filters, especially their phase delays, can be more important than properties of symmetric filters. Our phase delay results illustrate that adjusters who favor smoother seasonal adjustments, or who favor trends for their greater smoothness, must usually reckon with greater delay of turning point and business cycle information for the most recent months. Trend filters are considered briefly. New analytical results are obtained for transfer functions and phase delays.