Miracle-dz/UniFAR-FTUs huggingface dataset:
Derepressed levels of glutamate synthase and glutamine synthetase in Escherichia coli mutants altered in glutamyl-transfer ribonucleic acid synthetase

The levels of glutamate synthase and of glutamine synthetase are both derepressed 10-fold in strain JP1449 of Escherichia coli carrying a thermosensitive mutation in the glutamyl-transfer ribonucleic acid (tRNA) synthetase and growing exponentially but at a reduced rate at a partially restrictive temperature, compared with the levels in strain AB347 isogenic with strain JP1449 except for this thermosensitive mutation and the marker aro. These two enzymes catalyze one of the two pathways for glutamate biosynthesis in E. coli, the other being defined by the glutamate dehydrogenase. We observed a correlation between the percentage of charged tRNAGlu and the level of glutamate synthase in various mutants reported to have an altered glutamyl-tRNA synthetase activity. These results suggest that a glutamyl-tRNA might be involved in the repression of the biosynthesis of the glutamate synthase and of the glutamine synthetase and would couple the regulation of the biosynthesis of these two enzymes, which can work in tandem to synthesize glutamate when the ammonia concentration is low in E. coli but whose structural genes are quite distant from each other. No derepression of the level of the glutamate dehydrogenase was observed in mutant strain JP1449 under the conditions where the levels of the glutamine synthetase and of the glutamate synthase were derepressed. This result indicates that the two pathways for glutamate biosynthesis in E. coli are under different regulatory controls. The glutamate has been reported to be probably the key regulatory element of the biosynthesis of the glutamate dehydrogenase. Our results indicate that the cell has chosen the level of glutamyl-tRNA as a more sensitive probe to regulate the biosynthesis of the enzymes of the other pathway, which must be energized at a low ammonia concentration.
A Functional Relationship Between Capillary Pressure, Saturation, and Interfacial Area as Revealed by a Pore‐Scale Network Model

The constitutive relationships required for the parameterization of multiphase flow and transport problems are of critical importance to hydrologic modeling. Recently, a hypothesis has been developed that predicts a functional relationship between capillary pressure, saturation, and interfacial area. A network model was developed to test this hypothesis. Microscale physical processes were simulated and volume averaging was used to derive the macroscopic measures of saturation andfluid-fluid interfacial area per volume of porous media. Results indicate that a smooth, though complex, functional relationship exists at the continuum scale. These results have direct relevance to constitutive theory and the modeling of nonaqueous phase liquid dissolution processes.
Coarse-grained mtime update for better fsync() performance

This work is dedicated to improve the performance of the fsync(), which is one of the most expensive system calls in UNIX operating systems. Due to the recent advancement of the Flash storage based storage device, the storage device can flush the data blocks in order of magnitudes faster than the legacy HDDs. Often, the rate of flushing the data blocks to the storage device prevails the rate of CPU updating the file system time. The amount of the dirty blocks created in the system depends on the timer interrupt interval of the kernel. Read and write operations update the atime and mtime metadata, respectively. These timestamps are useful; however, there is significant performance degradation due to frequent updates of the metadata. Now in the file system, atime has several options to mediate between usefulness and performance efficiency. Most of the Database Management Systems frequently perform fsync() to guarantee the consistency of user data. The synchronous writes involve journaling overhead of updating mtime metadata in EXT4 file system. However, the effect of frequent update of mtime on write intensive workload has been overlooked. We introduce coarse-grained mtime update scheme to increase the mtime/ctime timestamp update interval while maintaining the same level of resolution for kernel time interrupts. As a result, coarse-grained update interval scheme reduces the journaling overhead with the least effort. The experiment results show that the I/O performance of random workload on mobile and PC increased about 7+ and 107+ against the default mtime update interval, respectively. The result of insert operations on PERSIST mode of SQLite on mobile and PC shows 8.4+ and 45.1+ of I/O performance increase, respectively. On MySQL OLTP workload, the performance increased by 7.9+.
Basic Accident Cause Analysis of Relations with Individual Commitment in Effort to Prevent Occupational Accidents at Rumah Sakit X

Hospital is one of the workplaces that have a variety of risks that could adversely affect health and safety. Data of occupational accidents in RS X is 1 accident in 2012 and 2 accidents in 2014. The accident data indicate not optimal management control in the implementation of OSH at RS X Surabaya. The purpose of this study is to analyze the relationship between the basic causes of the accident with the individual commitment efforts to pevent occupational accidents at RS X Surabaya. This research is a quantitative research with cross sectional design was conducted in October-November 2015. Large population of 180 people and a sample obtained by simple random sampling technique as many as 65 people. Results with Pearson correlation analysis there was no relationship between the length of work with individual commitment. OSH policies, infrastructure, financing, human resources of OSH, OSH training, and the provision of PPE there is a relationship with the individual commitment. Individual commitment are not related to work behavior. Results of path analysis showed that there is a relationship between infrastructure, financing, human resources of OSH, and OSH training with individual commitment. Recommendations are given for the RS X is adjusting infrastructure with attachments Kepmenkes No. 1087 In 2010, the hospital gave budgets sufficient funds for the implementation of OSH, hospitals procure new human resources special of OSH, OSH training in accordance with needs, and RS do efforts to increase individual commitment.
Pengaruh Functional Quality Dan Technical Quality Pada Customer Loyalty Dengan Trust Dan Commitment Sebagai Variabel Intervening Di PT. Aura Desain Mitra Kreasi

This research aims to analyze the influence of Functional Quality and Technical Quality towards Customer Loyalty through Trust and Commitment as an Intervening Variabel at PT. Aura Desain Mitra Kreasi. This research will be conducted by distributing questionnaires to 46 respondents which are consumer of PT. Aura Desain Mitra Kreasi. Quantitative analysis with path analysis analysis model method were used for the technical analysis.The results of this study indicate that the functional quality influence positively and significantly related to trust, functional quality influence positively and not significantly related to commitment, technical quality influence positively and significantly related to trust, technical quality influence positively and not significantly related to commitment, trust influence positively and significantly related to commitment, trust and commitment influence positively and significantly related to customer loyalty.
Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia.

BACKGROUND Promising results of cord-blood transplants from unrelated donors have been reported in adults. METHODS We compared outcomes in 682 adults with acute leukemia who received a hematopoietic stem-cell transplant from an unrelated donor: 98 received cord blood and 584 received bone marrow. The transplantations were performed from 1998 through 2002 and reported to Eurocord and the European Blood and Marrow Transplant Group. RESULTS Recipients of cord blood were younger than recipients of bone marrow (median, 24.5 vs. 32 years of age; P<0.001), weighed less (median, 58 vs. 68 kg; P<0.001), and had more advanced disease at the time of transplantation (52 percent vs. 33 percent, P<0.001). All marrow transplants were HLA matched, whereas 94 percent of cord-blood grafts were HLA mismatched (P<0.001). The median number of nucleated cells that were infused was 0.23x10(8) per kilogram of the recipient's body weight for cord blood and 2.9x10(8) per kilogram for bone marrow (P<0.001). Multivariate analysis showed lower risks of grade II, III, or IV acute graft-versus-host disease (GVHD) after cord-blood transplantation (relative risk, 0.57; 95 percent confidence interval, 0.37 to 0.87; P=0.01), but neutrophil recovery was significantly delayed (relative risk, 0.49; 95 percent confidence interval, 0.41 to 0.58; P<0.001). The incidence of chronic GVHD, transplantation-related mortality, relapse rate, and leukemia-free survival were not significantly different in the two groups. CONCLUSIONS Cord blood from an unrelated donor is an alternative source of hematopoietic stem cells for adults with acute leukemia who lack an HLA-matched bone marrow donor.
Influence of tissue inhomogeneities on noninvasive muscle fiber conduction velocity measurements-investigated by physical and numerical modeling

The hypothesis that the observed fluctuations in propagation velocity are caused by electrically inhomogeneous tissue, regions of different electrical conductivity which are located between the excited muscle fibers and the recording electrodes and which cause a deformation of the extracellular electric current field, was examined. The investigation was performed by means of a physical model as well as by finite element model calculations. In both models single, simple shaped (cylindrical) inhomogeneity regions with a conductivity of 0.1 to 10 times that of the surrounding medium and diameters ranging between 1.6 and 2.7 mm were placed between excitation sources and recording site. The results indicate that the observed conduction velocity fluctuations of up to some 10% can be attributed to inhomogeneity effects of the tissue conductivity. <<ETX>>
THE GOULD’S BELT VERY LARGE ARRAY SURVEY. II. THE SERPENS REGION

We present deep (∼17 μJy) radio continuum observations of the Serpens molecular cloud, the Serpens south cluster, and the W40 region obtained using the Very Large Array in its A configuration. We detect a total of 146 sources, 29 of which are young stellar objects (YSOs), 2 of which are BV stars, and 5 more of which are associated with phenomena related to YSOs. Based on their radio variability and spectral index, we propose that about 16 of the remaining 110 unclassified sources are also YSOs. For approximately 65% of the known YSOs detected here as radio sources, the emission is most likely non-thermal and related to stellar coronal activity. As also recently observed in Ophiuchus, our sample of YSOs with X-ray counterparts lies below the fiducial Güdel & Benz relation. Finally, we analyze the proper motions of nine sources in the W40 region. This allows us to better constrain the membership of the radio sources in the region.
The increasing use of CT and its risks.

Emergency Department Use The use of CT has increased at an even higher rate in many EDs. One ED reported a patient increase of 13% between 2000 and 2005, with a disproportionately higher increase in the use of CT over the same period (see Table 1). The increase in CT use is driven by ever-increasing detection capabilities, as well as by the increasing availability of CT scanners. Additionally, many departments consider CT the first test for many conditions. Physicians might be replacing clinical judgment and time-consuming physical examinations with a “let’s do a quick CT” approach to emergency medicine. A trauma patient in the Yale University Medical Center ED might have his or her entire body scanned.
Méthodes de sélection de variables appliquées en spectroscopie proche infrarouge pour l'analyse et la classification de textiles

Les methodes d'analyse multivariee permettent d'extraire l'information presente dans les donnees spectroscopiques experimentales pour la prediction d'une propriete d'interet. La dimensionnalite des donnees en spectroscopie proche infrarouge est telle qu'une selection des variables spectroscopiques et d'echantillons est necessaire afin d'ameliorer les performances, la robustesse des modeles ou de tendre vers une instrumentation simplifiee. L'analyse rapide de la composition chimique des echantillons textiles est fondamentale dans certaines applications. Une premiere etude concerne la determination de la teneur en coton dans des melanges de fibres coton/polyester et coton/viscose par spectroscopie proche infrarouge. Afin d'ameliorer les capacites predictives obtenues sur les spectres complets, deux procedures de selection de variables, l'information mutuelle et les algorithmes genetiques, ont ete appliquees. L'erreur standard de prediction obtenue pour le lot coton/polyester est de 2,53% sur les 8 variables selectionnees par l'information mutuelle. Une seconde etude presente l'analyse qualitative pour la classification d'echantillons textiles dans trois classes par rapport a une propriete physico-chimique d'interet. La methode des support vector machine presente des resultats performants avec un taux d'echantillons bien classes en prediction de 88,8%. La reduction arbitraire du nombre de variables spectroscopiques a permis de montrer que les capacites predictives obtenues sur les spectres complets ne sont pas degradees. Ces resultats sont confirmes par l'utilisation d'une instrumentation simplifiee.
Genomewide linkage scan for quantitative trait loci underlying variation in age at menarche.

CONTEXT Age at menarche (AAM) is an important anthropological variable that has major implications for a woman's health later in life. Genetic influence has been shown to contribute greatly to AAM, but the specific genetic determinants are largely unknown. OBJECTIVE The objective of this study was to identify the quantitative trait loci (QTL) underlying the variations in AAM. METHODS We performed a large-scale, genomewide, linkage scan in 2461 Caucasian women from 402 pedigrees. All subjects were genotyped with 410 microsatellite markers spaced approximately 8.9 cM apart across the human genome. Using the variance component method, we conducted multipoint linkage analyses and two-locus tests for epistatic interaction. RESULTS The strongest linkage signal was obtained at the genomic region of 22q13 (LOD, 3.70); the other two suggestive linkages were on 22q11 (LOD, 2.68) and 11q23 (LOD, 1.98), respectively. We also detected significant epistatic interaction between genomic regions 22q13 and 3q13. CONCLUSIONS The identification of QTL and epistatic interaction in a large female sample laid a foundation for independent replication and fine-mapping studies as well as positional and functional candidate gene studies aimed at finding the causal genetic variants and hidden mechanisms concerning the variations in AAM.
Business Ethics-Does it Pay

This study investigates the UK and US companies who had codes of ethics/conduct/Principles and those who explicitly said they did not. This study relies on the data which was available from various secondary sources like Annual report of companies, Ratings given by different agencies to name a few. We divided companies into two cohorts – who had code of ethics and without it. We have done an extensive research and filtered companies from the list of 581 companies. We then tried to find relationship between financial and non financial parameters. We have tried to relate both and show its effect on the companies. The above figure clearly shows that the companies who are better able to manage its stakeholders i.e. Customers, employees and investors are better able to increase the financial impact in the form of increase of lower costs, premium price products etc. to name a few. The findings that we have got are also testimony to this fact. On the other hand, we have looked onto the financial performance in the form of EVA, MVA, ROCE and P/E ratio volatility. The results we have got clearly favours the companies which have a code of ethics in the form of higher MVA, EVA, ROCE and lesser P/E volatility as compared to others which doesn’t have it. Thus, it is important for companies to better able to manage its code of ethics in place in order to have greater growth on all aspects. Keywords:Businessethics,Companies,EVA,MVA.
PENGUNGKAPAN SYARIAH PADA BANK SYARIAH DI INDONESIA

This study aims to examine the disclosure of sharia Islamic banks in Indonesia. With the i ndependent variable is the size of the supervisory board of sharia, cross membership of the sharia supervisory board, sharia supervisory board member with expertise in accounting, banking, economics, and finance on the disclosure of zakat, the disclosure report of the supervisory board of sharia and sharia supervisory board disclosures in the annual reports of Islamic banks.The population in this study is the entire Islamic banks in Indonesia in 2011, 2012, and 2013. The number of banks research sample totaled 33. In order to obtain research data for 33 samples of data. The analysis technique used is a multiple regression analysis.The analysis showed that the disclosure of zakat is significantly affected by the size of the sharia supervisory board, cross memberships of the sharia supervisory board, and sharia supervisory board expertise in accounting / economics / banking / finance. Disclosure of Shariah supervisory board report significantly influenced by sharia supervisory board expertise in accounting / economics/ banking/ finance. While disclosure of sharia supervisory board significantly influenced by cross- membership of sharia supervisory board
Absorption and elimination of carbon monoxide by inactive young men.

Human volunteers were exposed to carbon monoxide at concentrations of < 1, 25, 50, 100, 200, 500, and 1,000 ppm for periods of one-half to 24 hours. Blood samples for carboxyhemoglobin (COHb) were obtained during the exposures and for up to 23 hours into the postexposure periods. Postexposure treatment with oxygen at 1.0 and 3.0 atmospheres was included. Several model equations were tested against the absorption and excretion data; one theoretical equation accurately predicted COHb levels resulting from continuous and discontinuous exposures to unvarying concentrations and from continuous exposure to a steadily rising concentration.
Chapter 17 Text mining in life sciences

Efficient information retrieval and extraction is a major challenge in molecular biology and genome-based clinical research. In addition, we realize an increasing demand to combine information from different resources and across different disciplines in life sciences. A large fraction of this information is only available in scientific articles. Now the immense volume of literature makes it almost impossible for biologists and clinical researchers to retrieve all relevant information on a specific topic and to keep up with current research. Text mining provides the methods to automatically retrieve and extract information contained in free text. Furthermore a structured representation formalized by ontologies is required to combine the extracted knowledge with other sources. Examples are descriptions of protein interactions or clinical phenotypes that can be used to analyze large scale experiments in drug development.
Wideband printed tapering quadrifilar helical antenna for GNSS

A wideband conical printed tapering quadrifilar helical antenna for Global Navigation Satellite System (GNSS) is presented. By wrapping four printed tapering helical strips on the surface of modified hollow conical dielectric rod and using wideband network with stable amplitude and phase distribution to feed, the proposed antenna are effectively designed to achieve wide bandwidth, desired gain and wide angle axial ratio characteristics, which are mainly required for GNSS receiver, especially for measured receiver with high precision.
Differentiation of primary and secondary Raynaud's disease by carotid arterial stiffness.

INTRODUCTION primary Raynaud's disease may be difficult to differentiate clinically from the secondary form with an underlying connective tissue, haematological, neurovascular or drug-induced disorder. We undertook a study to determine the elastic carotid and muscular femoral arterial biomechanical properties and intima-media thickness (IMT) in subjects with primary and secondary Raynaud's disease, to assess whether these parameters could differentiate the two conditions. METHODS twenty patients with primary Raynaud's disease and 53 subjects with secondary Raynaud's associated with scleroderma (systemic sclerosis, SSc) had measurements of their carotid and femoral wall mechanics with a duplex scanner coupled to a Wall Track system. Their age, gender, body mass index, heart rate, systolic and diastolic blood pressures, presumed cardiovascular load, plasma creatinine, fasting cholesterol, triglyceride and glucose concentrations were also measured. RESULTS the carotid elastic properties [mean (SD): elastic modulus: 560 (180) vs 1204 (558) mmHg,p <0.001 and stiffness index: 5.69 (1.35) vs 11.92 (6.4), p<0.001 for primary and secondary Raynaud's respectively] were significantly impaired in patients with secondary Raynaud's disease even after adjustment for potentially influencing physiological and biochemical variables. There were no statistical differences in the femoral elastic properties or the carotid and femoral IMTs between the two groups. CONCLUSION Duplex determination of the carotid elasticity or stiffness is different in primary Raynaud's phenomenon compared with secondary Raynaud's associated with SSc. This may be a useful non-invasive tool, in addition to autoantibody markers and nail-fold capillaroscopy, to differentiate between the two forms of Raynaud's phenomenon.
The issue of site selection of service sectors and its influence on firms’ competitive advantage

The process of finding the optimal location is an issue that concerns the overwhelming majority of economic activities. The paper analyzes the factors influencing site selection of firms in the service sector in the context of modern competitive conditions. The above is accomplished through the case study of the development of “Mikel” coffee company outlet network. The work is based on qualitative research in the form of interviews conducted with key executives and the owners of the company. In the first part of the paper, the relevance of Porter’s “Diamond” model with the site selection model that was adopted by “Mikel” company for the development of its establishments is presented. In doing so, we question the importance of the role of government which is highlighted in Porter’s model. In the second part of the study, the six determinants of site selection of the firm are presented, which stem from the competitive environment. Specifically, agglomeration economies - commerciality, transport systems, existing competition, social capital - population, the time value of the location and the direction of traffic - distinctiveness of the site. The research results presented in this study, shape a rather detailed picture of the processes of finding the optimal location for economic activities, producing significant benefit for the firms as well as for the local economies and societies, in which they operate and grow.