Miracle-dz/UniFAR-FTUs huggingface dataset:
Research on the factors with implications on rheological properties of doughs.

The aim of this work is to contribute to the knowledge and the understanding the mechanisms of action of xylans and xylanases which is not fully understood yet. The xylanases are used extensively with positive results in breadmaking, along amylase and ascorbic acid. The use of xylanases is based on transforming insoluble xylans with negative effects on baking in soluble xylans with positive effects. The soluble xylans could be hydrolyzed too which lower the viscosity of medium. This study aims to determine how different xylanases modify the viscosity of xylans solution, haw much insoluble pentosans could be solubilized and mostly how the dough’s rheological properties of are modified.
Impact of Metronomic Chemotherapy on Quality of Life in Recurrent, Residual and Metastatic Head & Neck Cancers

Impact of Metronomic Chemotherapy on Quality of Life in Recurrent, Residual and Metastatic Head & Neck Cancers Authors Shilpa Kandipalli, Santhosh. V, Praveena Voonna Department of Medical Oncology, Sri Venkateswara Institute of Medical Sciences (SVIMS), Tirupati – 517507, India Corresponding Author Shilpa Kandipalli Mobile no: 9440731463, 9490075199, Email: shilpakandipalli@gmail.com Abstract Background: Quality of life is significantly affected in both radically treated as well as palliative care patients of Head & Neck cancers. Both Surgery as well as Radiation with concurrent chemotherapy affect quality of life with long lasting disabilities. Hence the present study was done to evaluate the role of Metronomic Chemotherapy on Quality of life in Residual, Recurrent and Metastatic Head & Neck cancers. Methods: All patients who met the inclusion criteria in our study were treated with Oral Metronomic Chemotherapy with Methotrexate and Capecitabine. Quality of Life assessment was done at month 0, month 3 and month 6. Results: The predominant problematic domains identified by QOL H&N-35 scale were pain, difficulty in swallowing, dry mouth, mouth opening, sticky saliva, social eating, social contact and less sexuality. There is a significant improvement in QOL of most of the survivors in the present study at the end of 6 months. But there was no significance as far as illness, senses, coughing, feeding tube and weight gain are concerned Conclusion: Oral Metronomic Chemotherapy with Methotrexate and Capecitabine significantly improves the Quality of life in patients with Residual, Recurrent and Metastatic Head & Neck cancers.
Genetically modified plants as animal feed.

s and Reviews, Series B: Livestock Feeds and Feeding: 70 (3):175-182. Beever, D.E. , and R.H. Phipps. 2001. The fate of plant DNA and novel proteins in feeds for farm livestock: A United Kingdom perspective. J. Anim. Sci. 79: E290-E295. Betz, F.S. , B.G. Hammond, and R.L. Fuchs. 2000. Safety And Advantages Of Bacillus ThuringiensisProtected Plants To Control Insect Pests. Regulatory Toxicology and Pharmacology. 32:156173. Brookes, G. , and P. Barfoot. 2008. Global impact of biotech crops: Socio-economic and environmental effects, 1996-2006. AgBioForum 11(1): 21-38. Council for Agricultural Science and Technology (CAST). 2006. Safety of Meat, Milk, and Eggs from Animals Fed Crops Derived from Modern Biotechnology. Issue Paper 34. CAST, Ames Iowa. EPA. 1998. (RED Facts) Bacillus thuringiensis.
Una nuova generazione di batteri malolattici per vini a pH elevato

Introduzione La fermentazione malolattica, che consiste nella conversione di un acido dicarbossilico, l’acido malico, in un acido monocarbossilico, l’acido lattico, avviene nel vino a causa dell’attività metabolica di alcuni ceppi di batteri lattici. La riduzione dell’acidità e la modificazione dell’aroma dovuti a questa fermentazione secondaria sono considerati positivi per la qualità del vino. La fermentazione malolattica contribuisce anche alla stabilità microbica dal momento in cui vengono degradati dei substrati suscettibili al metabolismo di più specie batteriche. Dalla superficie dell’uva, delle foglie, del suolo e delle attrezzature di cantina entrano nel mosto, e poi nel vino, differenti specie di batteri lattici (LAB). Comunque, a causa delle condizioni fortemente restrittive alla loro crescita, solamente un piccolo gruppo di batteri specializzati sono capaci di crescere nel succo d’uva e successivamente nel vino. I batteri lattici associati all’industria enologica appartengono a 4 generi: Oenococcus, Leuconostoc, Lactobacillus e Pediococcus. Oltre ad O. Oeni, nel vino si possono comunemente isolare tre specie di Pediococcus e sette specie di Lactobacillus. Il pH del vino è un fattore fortemente selettivo e generalmente sotto pH 3,5 soltanto i ceppi della specie Oenococcus oeni riescono a sopravvivere e ad esprimere una efficace attività malolattica, mentre in vini con pH superiore a questo valore anche altre specie dei generi Lactobacillus e Pediococcus hanno la possibilità di condurre la FML. Oenococcus oeni è quindi la specie meglio adattata alle difficili condizioni enologiche ed è il batterio comunemente presente negli starter malolattici commerciali, sebbene già in passato alcune specie di Lactobacillus abbiano mostrato una incoraggiante sopravvivenza nel vino (Davis et al., 1988; Krieger, 1989, Lonvaud-Funel, 1999, Fumi 2009). Lactobacillus plantarum si è dimostrato il batterio più promettente per le colture starter nei vini a pH alto (Prahl 1989; Bou e Krieger, 2004), ed è stato recentemente dimostrato essere in possesso di un più ampio corredo enzimatico capace di influire sul profilo sensoriale del vino (Mtshali et al., 2009) rispetto al classico O. oeni.
Advances in wildlife immobilisation and anaesthesia

Improvement of chemical capture is an important part of wildlife conservation and animal welfare to minimise distress for the animals and the risk of morbidity and mortality. The aim of this thesis was to improve wildlife immobilisation and anaesthesia by studying physiological variables and clinically evaluate different drug combinations and methods of capture in selected species. Reversible anaesthetic protocols were developed for use in free-ranging lions and four species of South- East Asian primates. Capture and anaesthesia of free-ranging wolverines, brown bears, black and white rhinoceros were physiologically evaluated. The effect of intranasal oxygen supplementation on arterial oxygenation was assessed in brown bears and rhinoceros. Partial reversal of the opioid effect and different body positions were evaluated in rhinoceros. Capture methods used included darting from a helicopter or the ground, and physical restraint followed by drug injection. Medetomidine-ketamine was used in wolverines and medetomidine-zolazepam-tiletamine in primates, lions and brown bears. Rhinoceros were immobilised with a combination of an opioid, azaperone and an alpha2-agonist. Body temperature and cardiorespiratory variables were monitored in all animals. Arterial blood samples were analysed to interpret pulmonary gas exchange and acid-base status in carnivores and rhinoceros. Low doses of medetomidine-zolazepam-tiletamine rapidly anaesthetised primates and lions, and reversal with atipamezole resulted in a smooth and calm recovery. Physiological alterations varied with different protocols and species and included changes in body temperature, respiratory and heart rates, gas exchange and acid-base balance. Hypoxaemia was recorded in all rhinoceros and most carnivore species. The major contributor to hypoxaemia was likely ventilation-perfusion mismatch including shunt. In rhinoceros, hypoventilation contributed to an impaired gas exchange and the animals remained hypoxaemic despite partial reversal. However, in black rhinoceros arterial oxygenation was higher during sternal compared to lateral recumbency. Capture-induced lactic acidaemia was recorded in carnivores and rhinoceros. Intranasal oxygen supplementation improved arterial oxygenation. In conclusion, this thesis increases the understanding of the effects of capture and anaesthesia in several wildlife species. Physiological derangements were identified, potential causative factors were investigated and methods for improvement were evaluated.
Patterns of Coverage Gains Among Young Adult Cancer Patients Following the Affordable Care Act

Abstract The dependent coverage expansion (DCE) and Medicaid expansions (ME) under the Affordable Care Act (ACA) may differentially affect eligibility for health insurance coverage in young adult cancer patients. Studies examining temporal patterns of coverage changes in young adults following these policies are lacking. We used data from the National Cancer Database 2003–2015 to conduct a quasi-experimental study of cancer patients ages 19–34 years, grouped as DCE-eligible (19- to 25-year-olds) and DCE-ineligible (27- to 34-year-olds). Although private insurance coverage in DCE-eligible cancer patients increased incrementally following DCE implementation (0.5 per quarter; P < .001), an immediate effect on Medicaid coverage gains was observed after ME in all young adult cancer patients (3.01 for DCE-eligible and 1.62 for DCE-ineligible, both P < .001). Therefore, DCE and ME each had statistically significant and distinct effects on insurance coverage gains. Distinct temporal patterns of ACA policies’ impact on insurance coverage gains likely affect patterns of receipt of cancer care. Temporal patterns should be considered when evaluating the impact of health policies.
Influencia del osmóforo en la producción de infrutescencias en "Arum italicum" Miller ("Araceae")

The influence of the appendix of the spadix, of phenology and of inflorescence number on the infructescence set in a Northern Spanish population of Arum italicum was studied. The experimental design included leaf removal. nutrient supply and appendix removal by herbivorous rodents. The number of flies trapped in the inflorescences was related to appendix size. Late anthesis resulted in infructescence set more frequently than early anthesis. The predation on the appendix decreased the probability of infructescence set by 30 %. The percentage of open inflorescences that began fruit maturation was 40%, combining all plants preyed upon. Otherwise, plants having two or three inflorescences exhibited higher probability of fruit set. Nutrient supply and leaf removal did not increase infructescence set. but increased the incidence of the predation.
Viability and in vitro germinability of pollen grains of olive cultivars and advanced selections obtained in Italy

In the frame of a breeding programme of olive, started in 1971 and carried out at the Department of Horticulture of the University of Florence (Italy), 134 advanced selections are under evaluation. Viability and germinability have been evaluated on pollen grains collected from trees (11 advanced selections and four culti- vars, 'Carolea', 'Frantoio', 'Leccino'and 'Moraiolo') grown at Spoleto (province of Perugia). Pollen grains have been stored at different temperatures (-20°C, +4°C and +20°C) and for 7, 35 and 200 days from full bloom. Via- bility was assessed by means of fluorescence microscopy; in vitro germinability was evaluated on pollen grains cultivated in 10 different growing media. Pollen grains showed different rates of viability and germinability in relation to storage length, storage temperature, genotype and their interactions. Storage length had a statistical - ly significant effect both on pollen grain viability and germination. No linearcorrelation has been found between viability and germination rates. Some advanced selections showed levels of pollen grain viability and germina - bility comparable to those of cultivars used also as pollinizers.
SICLOPPS Derived Libraries as a Means to Rescue Complex Formation Inhibited by Cancer Mutations

According to the American Cancer Society, one in four males and one in five females have a 100% lifetime risk of dying from cancer. Cancer is a major burden on modern society, from stealing away precious years of health to putting stress on an already over burdened health care system. While some drugs might work better on general types of cancer, it is plausible to create cures for cancers based on specific mutations found within key regulatory proteins. Two complexes that are relevant to cancer biology, and are prime targets for drug modification, include a p53/DNA complex and a BARD1/BRCA1 protein-protein dimer. Both complexes are commonly mutated in human cancers and many of those mutations inhibit formation of signaling complexes required for keeping cancerous growth in check. Using libraries of small, cyclic, genetically encoded molecules, made by the SICLOPPS method, it is possible to seek scaffolds for future cancer drugs. Before being able to screen with confidence, however, it is first necessary to study SICLOPPS molecule interactions on the functional screens used to monitor p53/DNA and BRCA1/BARD protein complex association and formation in order to learn how to optimize the screening process. In conclusion, insight was gained into how to use novel functional assays with SICLOPPS derived libraries and in the future large numbers of SICLOPPS molecules will be screened against important cancer associated complexes in order to rescue complex formation.
Acute Modulation of Endothelial Cell Glucose Transport: A Dissertation

Studies have demonstrated that under conditions of chronic metabolic stress, GLUT1mediated sugar transport is upregulated at the blood-brain barrier by a number of mechanisms. Although acute metabolic stress has also been shown to increase GLUT1mediated transport, the mechanisms underlying this regulation remain unclear. This work attempts to explain how GLUT1-mediated sugar uptake is increased during acute metabolic stress, as well as explore the factors involved in this modulation of sugar transport in blood-brain barrier endothelial cells. Glucose depletion, KCN and FCCP were applied to brain microvascular endothelial cell line bEnd.3 in order to induce acute metabolic stress by ATP depletion. Kinetic sugar uptake measurements in combination with qPCR, whole cell lysate western blots, and cell-surface biotinylation were employed to probe for changes in GLUT1-mediated sugar uptake, GLUT1 expression levels, and GLUT1 localization during metabolic stress. Finally, the role of AMP-activated kinase (AMPK) in the bEnd.3 cell response to acute stress was examined using the specific AMPK activator AICAR and inhibitor Compound C. The data presented in this thesis supports the following two conclusions: 1. GLUT1mediated sugar transport in bEnd.3 cells during acute metabolic stress is increased 3-7 fold due to translocation of intracellular GLUT1 to the plasma membrane, with no change in expression of total GLUT1 protein, and 2. AMPK plays a direct role in modulating increases in GLUT1-mediated sugar transport in bEnd.3 cells during acute metabolic stress by regulating trafficking of GLUT1 to the plasma membrane
Use of low-carbohydrate diets in patients with type 2 diabetes

Leczenie cukrzycy typu 2 na każdym etapie powinno być wspomagane odpowiednią dietą połączoną z aktywnością fizyczną. Kluczowym makroskładnikiem diety, mającym bezpośredni wpływ na wzrost glikemii po posiłku, są węglowodany. Od kilkudziesięciu lat badane są efekty interwencji dietetycznych polegających na ograniczeniu procentowego udziału węglowodanów w diecie na rzecz innych makroskładników. Dieta niskowęglowodanowa była i nadal jest sugerowana przez niektórych ekspertów oraz środowiska pacjentów jako najskuteczniejsza i niosąca najmniejsze ryzyko skutków ubocznych. Sugestie te nie są jednak poparte dowodami pochodzącymi z wysokiej jakości randomizowanych kontrolowanych badań klinicznych. Praca stanowi przegląd publikowanych w ostatnich latach metaanaliz randomizowanych kontrolowanych badań porównujących parametry mające znaczenie dla leczenia cukrzycy: glikemię na czczo, hemoglobinę glikowaną, lipidogram oraz redukcję masy ciała. Obecnie brak wystarczających dowodów naukowych do zalecania jednej, optymalnej ilości węglowodanów w diecie, wobec czego zalecenia te powinny być indywidualizowane. Większą rolę w podejmowanych interwencjach dietetycznych u chorych na cukrzycę typu 2 mają obniżenie całkowitej wartości energetycznej diety oraz jakość dostarczanych makroskładników, szczególnie węglowodanów i tłuszczów.
Age at Diagnosis of Preinvasive and Invasive Cervical Neoplasia in South Africa: HIV-Positive Versus HIV-Negative Women

Hypothesis: Human immunodeficiency virus-positive women develop invasive cervical cancer at a significantly earlier age than seronegative women. It is hypothesized that this might result from shorter preinvasive stages. Methods: Prospective observational study of histologically diagnosed 398 low-grade (LGSIL), 738 high-grade intraepithelial lesions (HGSIL), and 1048 invasive cancers (IC) in a black South African population. The study comprised of 493 (22.6%) seropositive women and 1691 (77.4%) seronegative women who served as the controls. All were subdivided into 5-years age bands. Results: The mean age at diagnosis of LGSIL and HGSIL was similar in the cases (t = 0.7; P = 0.49) and the controls (t = 1.2; P = 0.22). The mean age at diagnosis of IC was significantly younger in the HIV-seropositive women than in the HIV-seronegative women (t = 14.0; P < 0.0001). The relative age distribution curves of LGSIL, HGSIL, and IC evolved close to each other in the cases. In the seronegative women, there was an 18-year lag between the peak age distribution of HGSIL and IC. Conclusion: Our data support the hypothesis of a shorter preinvasive stage in HIV-positive women.
Effect of deficit irrigation on growth and yield of drip irrigated cabbage

A field experiment was conducted on cabbage crop (var. Indo-American Hybrid Ramakrishna) during the winter season of 2010-11 in loamy soil of Water Technology Centre, Indian Agricultural Research Institute, New Delhi. The objective of the study was to evaluate the effect of three levels of irrigation, i.e. 60, 80 and 100% of crop evapotranspiration (ETc) and two types of drip irrigation systems, viz. pressure compensating (PC) and non-pressure compensating (NPC) drippers on the cabbage growth and yield. Rated discharge of PC and NPC drippers were 1.0 and 2.1 litres per hour (lph). Cabbage crop was sown in November 2013 at the spacing of 30cm (plant to plant) and 60cm (row to row). Leaf Area Index (LAI) was recorded at initial, developmental, mid-season and maturity stages while the root volume was determined at the maturity stage of crop growth. Under PC system, the LAI values of 0.59, 0.90 and 2.07 were recorded at initial, developmental and middle stage of crop, respectively. During maturity stage, NPC dripper showed higher LAI (2.61) as compared to PC drippers (2.57). Increased wetting depth under NPC system resulted in higher root depth (70 cm) and higher root volume. The maximum and minimum yields obtained in PC drippers were 91.2 and 83.33 t/ha, whereas in the plot having NPC drippers, maximum and minimum yieldsobtained were 61.48 and 53.70 t/ha, respectively. Yield obtained under 80 and 100 % ETc was not significantly different, however full application of water (100%) resulted in better yield. Thus, Pressure compensating drippers with discharge matching to crop water needs (1.0 lph) and irrigation at 80 % ETc is recommended as optimum practice for cabbage cultivation in loamy soils of northern India.
Targeting on Morning Blood Pressure Surge

Morning blood pressure surge (MBPS) is an independent predictor of cardiovascular events. The most common definition of MBPS was a pre waking surge (mean blood pressure for 2 hours after wakeup minus mean blood pressure for 2 hours before wake-up). The sympathetic nervous system plays a major role in the regulation of BP variability. Asleep blood pressure has been shown to better reflect cardiovascular risk than awake BP in hypertensive patients. A possible link was found between disturbed sleep and MBPS. Exaggerated MBPS and increased low-grade inflammation independently increase the risk of stroke, while the relationship between exaggerated MBPS and the presence of silent cerebral infarct is slightly affected by low-grade inflammation. Furthermore, type 2 diabetes mellitus was an independent risk factor for increased MBPS. Serum uric acid, low density lipoprotein-cholesterol, anxiety disorder and so on may also involve in MBPS. Telmisartan was shown to normalize the circadian blood pressure pattern to a dipper profile in a larger proportion of patients than ramipril, and reduce early-morning systolic blood pressure surge in high-risk patients. Telmisartan alone or with HCTZ improved morning high blood pressure control and maintained a smooth high blood pressure profile throughout the day in a real-life setting. Furthermore, once-daily dosing of valsartan results in equally effective 24-hour blood pressure efficacy, regardless of dosing time. In total, future studies specifically designed to evaluate the real impact of MBPS on outcomes, as well as to define its optimal cutoff value, are required.
Diversity of small mammals communities in two semiartificial wooded habitats

Riassunto Diversita delle comunita di micromammiferi in due ambienti boschivi semi-naturali E’ stata indagata la composizione delle comunita di micromammiferi in due allevamenti intensivi di fagiani - “Hajek” (HJ) and “Rumunska” (RB), Moravia meridionale, Repubblica Ceca – differenti sia per composizione del habitat sia per densita di fagiani. Nel periodo 2002 – 2005, sono state complessivamente identificate 10 specie (7 roditori e 3 insettivori). La diversita (indice di Shannon-Weaver, H`) e risultata maggiore in RB (H`RB = 1.28; H`HJ = 1.11; t = 3.09: p< 0.01), mentre abbondanza relativa e equiripartizione non hanno mostrato differenze significative. La diversita e probabilmente influenzata dalla composizione e dalla struttura del habitat. In aree intensamente modificate dalle attivita agricole, gli allevamenti di fagiani possono rappresentare un “rifugio” per i piccoli mammiferi.
Comparative efficacy of qualitative and quantitative methods for rock phosphate solubilization with phosphate solubilizing rhizobacteria.

Some plant growth promoting rhizobacteria (PGPR) have the ability to solubilize the insoluble inorganic forms of phosphorus (P) through the production of specific metabolites such as organic acids. These phosphate solubilizing bacteria (PSB) are routinely screened by qualitative method (NBRIP medium agar plate assay) by observing the size of a halo/ clear zone on plate around the bacterial colony due to production of organic acids into surrounding medium. In this study, this qualitative method was compared with quantitative (colorimetery) method of measuring the P solubilization by PSB to evaluate the validity/accuracy of the former method. Results of quantitative and qualitative methods indicated that qualitative method did not reflect the real potential of PSB to solubilize insoluble P as no relationship was observed when values regarding P solubilization by PSB determined by qualitative method were regressed against respective values recorded for quantitative method. Interestingly, same strains which showed very poor performance in qualitative method were proven good P solubilizers in quantitative method and vice versa. It could be concluded that only quantitative method should be considered reliable when studying P solubilization by phosphate solubilizing microbe (PSM).
Selection Indices and Prediction of Genetic Merit in Animal Breeding

Introduction to variance ANOVA in a quantitative genetics framework regression and correlation identification of animals of high genetic merit information from relatives selection of index methodology examples of selection objectives and criteria factors affecting the rate of genetic improvement performance testing, progeny testing and MOET simultaneous prediction of breeding values for several animals prediction of breeding values and environmental effects multivariate breeding value prediction market assisted selection binomial traits appendix - matrix algebra questions answers.