Miracle-dz/UniFAR-FTUs huggingface dataset:
Patterns of growth factor usage and febrile neutropenia among older patients with diffuse large B-cell non-Hodgkin lymphoma treated with CHOP or R-CHOP: the Intergroup experience (CALGB 9793; ECOG-SWOG 4494)

Abstract Patterns of myeloid growth factor (GF) usage and febrile neutropenia (FN) were examined in patients >60 years of age with diffuse large B-cell non-Hodgkin lymphoma (DLBCL) enrolled on CALGB 9793/ECOG-SWOG 4494, receiving initial therapy with cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) or rituximab + CHOP (R-CHOP). Myeloid GFs were administered to 256/520 (49%) patients. Indications for use were: prevent dose reduction/dose delay (81%, 207/256); treat FN or non-febrile neutropenia (NFN) (19%, 48/256). One or more FN episodes occurred in 41% (212/520) of patients, with FN most often in cycle 1 (38% of episodes). In multivariate analysis, risk factors for FN included age >65 years (odds ratio (OR) = 2.6, 95% CI: [1.4, 4.9]) and anemia (hemoglobin <12 g/dl) (OR =2.2, 95% confidence intervals (CI): [1.4, 3.5]. Myeloid GF use was common in this older DLBCL population receiving CHOP-based therapy, as was FN, especially during cycle one. Risk factors predictive for FN should be used prospectively to identify patients for whom myeloid GFs are best utilized.
Determining the threshold for alcohol-induced brain damage: new evidence with gliosis markers.

BACKGROUND Chronic intake of ethanol (EtOH) has been linked to serious health consequences such as cardiac and liver problems, cognitive impairments, and brain damage. Alcohol's detrimental effects depend upon the dose, duration, and pattern of exposure with binge drinking as one of the most common, but most damaging, patterns of intake. Little is known about the threshold of the damaging effects of alcohol. Therefore, these experiments sought to determine a threshold for brain damage using various markers of neurodegeneration. METHODS Adult male Sprague-Dawley rats were administered nutritionally complete liquid diet containing either EtOH (25% w/v) or isocaloric dextrose every 8 hours for either 1 (mean dose, 13.4 ± 0.3 g/kg/d; mean blood EtOH concentration (BEC), 336.2 ± 18.8 mg/dl) or 2 days (mean dose, 10.9 ± 0.3 g/kg/d; mean BEC, 369.8 ± 18.1 mg/dl). On the basis of a known time course of various neurodegeneration-associated events, rats were perfused transcardially immediately following, 2 days after, or 7 days post EtOH exposure. To label actively dividing cells, some animals were injected with BromodeoxyUridine (BrdU) 2 hours prior to perfusion. Tissue was then analyzed for the presence of BrdU (cell proliferation), FluoroJade B (degenerative neurons), and vimentin (reactive astrogliosis) immunoreactivity. RESULTS One or 2 days of EtOH exposure failed to alter cell proliferation at any of the time points analyzed. However, significant 2- to 9-fold increases in neuronal degeneration in limbic cortex and clear evidence of reactive gliosis as indicated by a 2- to 8-fold upregulation in vimentin immunoreactivity in the hippocampus were observed following as little as 1 day of binge EtOH exposure. CONCLUSIONS These results indicate that as little as 1 day (24 hours) of high BEC, binge-like EtOH exposure is enough to elicit signs of alcohol-induced brain damage in adult rats. Further, reactive gliosis may be a more sensitive marker of alcohol-induced damage in the hippocampus.
Effect of Extracurricular Geriatric Medicine Training: A Model Based on Student Reflections on Healthcare Delivery to Elderly People

Although many professional and accrediting bodies have identified competencies for medical students pertaining to caring for older patients, including understanding the basics of the healthcare delivery system, the highly structured curriculum in medical school provides few opportunities for these competencies to be achieved. One possible solution is to let students participate in geriatrics‐related extracurricular educational and clinical activities and ask them to reflect on their experiences. This article presents the results of a qualitative analysis of student reflections from participating in such a program implemented at the University of Cincinnati College of Medicine. One hundred thirty of 321 student journal entries (collected over 3 academic years) containing any mention of the healthcare system were qualitatively analyzed. The themes and resulting model that emerged from the data includes three distinct levels of healthcare delivery: individual, organizational, and systems. Each level is presented and explained using illustrative student quotes. As a whole, the model indicates that students in this innovative extracurricular experience gained important knowledge about how medical care is provided to elderly people. The model developed may provide additional structure for future medical students as they reflect on their early encounters with the complex health and social forces affecting the quality of care received by older adults.
Cardiac β‐adrenoceptor sensitivity and Parkinson's disease

Summary— Certain clinical manifestations of Parkinson's disease (PD) (speech or/and balance disturbances) are not linked to brain dopamine deficiency. The purpose of the present study was to search for a possible relationship between those so‐called “non‐dopamine‐dependent” extrapyramidal manifestations and the sensitivity of cardiac β‐adrenoceptors. Fourteen patients aged 51 to 69 were included in the study after having given their informed consent. Any factor or pathology susceptible to modify receptor sensitivity entailed exclusion. In the absence of a reference model for measuring the reactivity of central β‐adrenoceptors, a computation of the isoprenalin dose necessary to increase the resting heart rate by 20 bpm was used as an index for β‐adrenergic system reactivity. In addition to that test, other parameters were recorded: disease duration, motor status scale (Columbia), some cognitive functions (MMS and image differed recall). The cardiac β‐receptor decrease in reactivity to isoproterenol is correlated to PD duration (r = 0.8, P < 0.001). Conversely, the sensitivity of these receptors appeared to be unrelated to the extrapyramidal severity of the disease, hence to the degree of the so‐called “non dopamine‐dependent” disturbances. Furthermore, such results raise the meaning of the impairment of peripheral aminergic receptors in the cognitive disturbances linked to ageing and/or PD.
‘We Can’: transforming power in relationships in South Asia

Throughout South Asia, gender-based violence against women continues to act as an impediment to the realisation of gender equality and women's rights. The ‘We Can’ campaign is a coalition of over 600 organisations from Bangladesh, Sri Lanka, India, Nepal, and Pakistan, working together to challenge and change entrenched attitudes that support and justify violence against women at the individual, community, and society levels. Of the campaign's activities, the most significant is the mobilisation of five million ‘Change Makers’, ordinary women and men prepared to speak up and take action against violence in their communities.
Consumption of fruits, vegetables, and risk of hematological malignancies: a systematic review and meta-analysis of prospective studies

Abstract We examined the association between fruit/vegetable consumption and the risk of hematological malignancies in cohort studies (end of search: August 31, 2016). Total fruit consumption was not associated with the risk of non-Hodgkin lymphoma (NHL) (RR = 1.03, 95% CI: 0.92–1.16, I2 = 12.1%, n = 7), acute myeloid leukemia (RR = 1.23, 95% CI: 0.94–1.61, I2 = 0%, n = 3), multiple myeloma (MM; RR = 1.05, 95% CI: 0.72–1.55, I2 = 60.0%, n = 4), and Hodgkin lymphoma. However, citrus fruit consumption was associated with reduced NHL risk (RR = 0.85, 95% CI: 0.73–1.00, p = .044, I2 = 0%, n = 6). Vegetable intake was marginally associated with reduced NHL risk (RR = 0.89, 95% CI: 0.79–1.00, p = .056, I2 = 16.2%, n = 7), but not with acute myeloid leukemia, multiple myeloma, and Hodgkin lymphoma risk. Nevertheless, NHL risk was inversely associated with cruciferous vegetable consumption (RR = 0.84, 95% CI: 0.71–1.00, p = .047, I2 = 0%, n = 3). Notably, combined fruit/vegetable consumption was associated with decreased NHL risk (RR = 0.79, 95% CI: 0.65–0.96, I2 = 11.2%, n = 3). This meta-analysis reveals possible protective effects; however, confounding and reporting bias could have affected the results.
Hipersensibilidade tardia a antígeno de Trypanosoma cruzi: III - sensibilidade do teste cutâneo com antígeno T12E no diagnóstico de doença de Chagas em pacientes hospitalizados

In this study we evaluated three immunologic methods for confirmation of clinical diagnosis of Chagas' disease, in 120 in-patients. The skin testing with the T12E antigen and the immunofluorescence were positive in 10% of cases. The hemagglutination was positive in 14.1% of these patients. The co-positivity of results of skin-testing with hemagglutination and of this latter with immunofluorescence reached 7.5% of cases. However, only 5% of co-positivity was achieved with results of skin testing, immunofluorescence and hemagglutination. Furthermore, 19.1% of the in¬patients showed at least one out of these exams to be positive. The specificity of the skin testing paralleled that of the immunofluorescence. The sensitivity of these exames, however, was lower than that obtained by the indirect hemagglutination. These data show that the skin testing with T12E antigen allows the diagnosis of Chagas' disease by a simple and handy method.
Computer–assisted interactive task guidance: Facilitating the performance of a simulated vocational task

Compensatory systems can be helpful for Individuals with traumatic brain injuries whose functional skills do not Improve in response to other types of treatment. An interactive computer–assisted compensatory cuing system, designed to assist brain–injured patients with the performance of functional skills, is described. By using this system, two of four patients Improved their performance of a simulated janitorial task. The advantages and disadvantages of interactive cuing systems are discussed, including their use as a pragmatic intervention for patients who benefit from successful experiences while they are learning at a much slower pace.
Comparison of injury in Iran national junior and youth football players

Football is one of the most popular sports in the world, but the rate of injury in this sport is high. A limited number of studies on the incidence of injuries in football players of differing ages have been published. The aim of this study was to establish a profile of injury in Iran national junior and youth football players. The team physician recorded details of all injuries that occurred during both training and matches. A total of 29 injuries were documented across both age groups, which is equivalent to an incidence of 36.51 injuries per 1000 play hours, the injury frequency rate during competition (64.15) being significantly (Z=2.51, p<0.05) higher than training (29.75). There was no significant difference in injury frequency between two age groups (36.1 injuries (U15) vs 37.9 injuries (U19) per 1000 h) (Z=0.05, p > 0.05) but junior players (U15) received more injuries during competition than youth players (U19) (86.08 injuries vs 46.41 injuries per 1000 h matches) (Z=2.43, p < 0.05). Also there was no significant difference in injury frequency during training (29.6 injuries vs 30.45 injuries per 1000 h training) (p > 0.05). Midfielders sustained greater percentage of injuries (55.2%). Most injuries were located in the lower extremities (n = 23, 79.3%), with the majority affecting the groin(31%) and ankle (17.2%) followed by thigh (13.8%) and knee (10.3%). Strains (34.5%) were the most common type of injury sustained in all players followed by sprains (17.2%) and contusions (17.2%). The overall rate of injury acquisition in the present investigation was 36.51 per 1000 h of exposure, this result was higher than recently observed for elite French youth football players (4.8). Junior players (U15) had twice as many injuries per 1000 h of exposure than youth players (U19). It seems that youth players (U19) are better trained to meet the demands of playing games than are junior players (U15).
MYC gene rearrangement in diffuse large B-cell lymphoma does not confer a worse prognosis following dose-adjusted EPOCH-R

Catherine Lai, Mark Roschewski, Christopher Melani, Stefania Pittaluga, Margaret Shovlin, Seth M. Steinberg, Kieron Dunleavy, Svetlana Pack, Elaine S. Jaffe and Wyndham H. Wilson Myeloid Malignancies Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA; Laboratory of Pathology, Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Biostatistics and Data Management Section, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Relação dos Índices Dermatoglíficos com Avaliação Isocinética e Ergoespirometria

Objetivo: O Objetivo geral desta dissertacao centra-se na relacao entre os indices dermatoglificos e os resultados da avaliacao isocinetica e da ergoespirometria, em jogadores de futebol profissional do Fluminense F.C. Metodologia: Estudo descritivo com tipologia relacional. Protocolo de Dermatoglifia (CUMMINS & MIDLO, 1942). Na avaliacao isocinetica os atletas foram avaliados a velocidade de 60o/seg. e 240o/s, sendo 5 e 55 repeticoes, respectivamente. Na ergoespirometria foi utilizado o protocolo de rampa ate a exaustao. Resultados: O Endurance Ratio apresentou uma significância de p ? 0,01 entre a resistencia anaerobica e os indices dermatoglificos. A correlacao entre o VO2max e o indice dermatoglifico W foi de ,818 e p ? 0,01. A correlacao entre o D10 e o W foi de ,908 e com o VO2max de ,794. O SQTL obteve uma correlacao de ,718 com o VO2max e de ,662 com o W todos com P? 0,01. O pique torque e a resistencia anaerobica obtiveram apenas uma tendencia de aumento do grupo I em relacao ao II. Conclusao e Recomendacoes: A descoberta da relacao significativa e da correlacao do VO2max com os indices dermatoglificos W, D10 e SQTL podera orientar o treinamento nao apenas nesta valencia, mas em todas as qualidades fisicas envolvidas. Alem disso, auxilia o treinamento fisico, tecnico e tatico, podendo ajudar ainda no correto posicionamento do atleta em campo para um melhor rendimento. A realizacao desta pesquisa em categorias de base poderia nos dar uma visao mais ampla do fenomeno, o que corrigiria os erros, visando um melhor aproveitamento do atleta no futuro, tanto no aspecto de rendimento quanto no de longevidade.
Evaluation of a Brief Alcohol Prevention Program for Urban School Youth.

OBJECTIVE: To examine the effects of the STARS for Families program, 2-year stage-based intervention using nurse consultations and parent prevention materials. METHODS: Subjects consisted of 650 sixth-grade students from one neighborhood (n=262_ and one magnet (bused) urban school (n=388). RESULTS: At posttest, significantly fewer intervention magnet-school students initiated alcohol use, drank heavily during the past 30 days, and drank over any period of time, compared to minimal intervention control students (p's Elementary School Student Late Childhood Child Substance Use Substance Use Prevention Parent Education School Based Prevention Program Intervention Program Substance Use Intervention Alcohol Use Prevention Alcohol Use Intervention Urban School Urban Youth 08-00
Dyes and Redox Couples with Matched Energy Levels: Elimination of the Dye-Regeneration Energy Loss in Dye-Sensitized Solar Cells.

In dye-sensitized solar cells (DSSCs), a significant dye-regeneration force (ΔG(reg)(0)≥0.5 eV) is usually required for effective dye regeneration, which results in a major energy loss and limits the energy-conversion efficiency of state-of-art DSSCs. We demonstrate that when dye molecules and redox couples that possess similar conjugated ligands are used, efficient dye regeneration occurs with zero or close-to-zero driving force. By using Ru(dcbpy)(bpy)2(2+) as the dye and Ru(bpy)2(MeIm)2(3+//2+) as the redox couple, a short-circuit current (J(sc)) of 4 mA cm(-2) and an open-circuit voltage (V(oc)) of 0.9 V were obtained with a ΔG(reg)(0) of 0.07 eV. The same was observed for the N3 dye and Ru(bpy)2(SCN)2(1+/0) (ΔG(reg)(0)=0.0 eV), which produced an J(sc) of 2.5 mA cm(-2) and V(oc) of 0.6 V. Charge recombination occurs at pinholes, limiting the performance of the cells. This proof-of-concept study demonstrates that high V(oc) values can be attained by significantly curtailing the dye-regeneration force.
The Role of Order in the Amplification of Light-Energy Conversion in a Dye-Sensitized Solar Cell Coupled to a Photonic Crystal.

We investigate the cause of amplification of light-energy conversion when coupling a nc-TiO2 film to a TiO2 inverse opal by comparing it to an inverse TiO2 glass (i-TiO2 -g) fabricated with the exact monodisperse air-hole size as an inverse opal with a stop band at 600 nm (600-i-TiO2 -o). A significant twofold average gain in the photon-to-current conversion efficiency is measured to the red of the stop band at the 600-i-TiO2 -o/nc-TiO2 bilayer under front-wall and back-wall illumination, greater than the gain within the stop band. A smaller amplification is measured under front-wall illumination-and no gain is measured under back-wall illumination-for i-TiO2 -g/nc-TiO2 at these energies. The photonic crystal therefore causes trapping of light through the bilayer, not only within the gap but also to the red, at frequencies within its dielectric band. This light-trapping effect is found to be dependent on structural order, as a highly disordered inverse glass film with the same air-hole size and thickness does not yield the same gain. A drop in the transmission of light is measured within the same frequencies to the red of the stop band upon adding nc-TiO2 to 600-i-TiO2 -o, consistent with light trapping in the bilayer.
Special Issue Introduction: HCI Studies in MIS

Human–computer interaction (HCI) is studied and researched by a variety of disciplines. This special issue showcases five research papers that examine HCI research in Management Information Systems (MIS). These are five of the best papers presented in the HCI in MIS sessions at the 12th International Conference on Human–Computer Interaction held in Beijing in July 2007. MIS is broadly defined as “the effective design, delivery and use of information systems in organizations” (Keen, 1980, p. 16). The two distinguishing features of MIS are its business-application focus and management orientation (Zhang, Nah, & Preece, 2004). Hence, HCI researchers in the MIS discipline are particularly interested in studying and understanding the ways humans interact with information, technologies, and tasks in business, managerial, and organizational contexts (Zhang et al., 2002). HCI research and teaching interests in MIS have been increasing over the last few years (Zhang, Nah, & Benbasat, 2005–2006) because of the importance of HCI in business and management. This special issue of International Journal of Human–Computer Interaction is the second issue sponsored by the Association for Information Systems Special Interest Group on Human Computer Interaction (AIS SIGHCI). AIS is the premier global organization for academics specializing in MIS. In 2001, Ping Zhang from Syracuse University and Fiona Fui-Hoon Nah from University of Nebraska-Lincoln cofounded the AIS SIGHCI, which provides a forum for AIS members to discuss, develop, and
International Perspectives on Patient Engagement: Results From the 2011 Commonwealth Fund Survey

We analyzed 2011 survey data of patients with complex health care needs in 11 countries (Australia, Canada, France, Germany, the Netherlands, New Zealand, Norway, Sweden, Switzerland, the United Kingdom, and the United States) on their care experiences. Wide country variation was reported in how well patients were engaged by their clinicians; UK and Swiss patients reported the most positive experiences, but gaps were reported in all countries. Disparities by income were found in several countries, with the widest gaps reported in the United States. Across countries, engaged patients reported receiving higher-quality care, fewer errors, and more positive views of the health system.
HOW TO MANAGE OVERACTIVE BLADDER IN ELDERLY INDIVIDUALS WITH DEMENTIA? A COMBINED USE OF DONEPEZIL, A CENTRAL ACETYLCHOLINESTERASE INHIBITOR, AND PROPIVERINE, A PERIPHERAL MUSCARINE RECEPTOR ANTAGONIST

routine CSF analysis, and electroencephalography. Our case is highly unusual, with early neuroimaging abnormalities and near-normal routine CSF findings. PCR confirmed HSE the same day. This case emphasizes the importance of early neuroimaging in elderly patients suspected of having HSE without CSF abnormalities. PCR detection of HSV DNA in CSF is presently considered to be the reference standard but may be negative during the first 24 to 48 hours after onset of symptoms. Also, PCR sensitivity can diminish 5 to 7 days after commencing antiviral treatment. EEGs show temporal lobe involvement as well as characteristic PLEDs and are fairly sensitive, particularly during the first 48 hours, although lacking specificity. Several publications have recently reported on the diagnostic value of diffusion-weighted MRI, suggesting that it is more sensitive than conventional T2weighted sequences in the early detection of HSE, although conclusive studies have not yet been performed. CT scans typically reveal hypodensities in the temporal lobes and frontal lobes (unior bilaterally), rarely with hemorrhagic components, and show gadolinium enhancement only during later stages of the disease. T2-weighted and MRI imaging studies, as well as fluid attenuated inversion recovery and diffusion-weighted sequences, commonly show more-extensive abnormalities corresponding to tissue edema, often including the inferior frontal and medial temporal lobes, and insular cortex and often sparing the basal ganglia. The neuroradiological findings in this patient are typical for HSE, although they appeared unusually early. Diagnostic tools are evolving but presently do not offer high enough sensitivity to exclude the presence of HSV in the early stages of the disease. Our case report suggests that conventional MRI should be performed early in the absence of other diagnostic clues. The efficacy of acyclovir 10 mg/kg given every 8 hours for 21 days has been proven in two randomized clinical trials. The effect of dexamethasone as an adjuvant treatment on survival and neurological sequelae of HSE in adults is being studied in the German trial of Acyclovir and Corticosteroids in Herpes Simplex Encephalitis, which is planned to conclude in 2011. In our patient, early acyclovir treatmentFbefore a pleocytosis appearedFdid not have a significant effect on outcome.
The effect of pre-treatment enquiries on child dental patient's post-treatment ratings of pain and anxiety

Abstract The aim of this study was to attempt to replicate a study in adults: to determine whether pre-treatment enquiries about anxiety and pain in children, attending the dentist, influenced their subsequent reports of pain and anxiety immediately after treatment. One hundred and ninety five children aged from seven to 16, attending four Community Dental Clinics, were allocated at random to five groups. Before treatment the first group was asked questions about their dental anxiety, expectations and memories of pain. The second group was asked about dental anxiety and expectations of pain. The third group was asked only about dental anxiety; the fourth was asked only about pain. The fifth, the control group, was asked about none of these topics. All the children were asked after treatment to rate 1) their anxiety about dentistry and 2) their experience of pain in the treatment just completed. The children experienced less pain than they had expected. There were no differences between the groups in disru.