Miracle-dz/UniFAR-FTUs huggingface dataset:
Ethnomedicinal, phytochemical and pharmacological updates on Peppermint (Mentha × piperita L.)—A review

Peppermint (Mentha × piperita L) is a perennial, glabrous and strongly scented herb belongs to the family Lamiaceae. It is cultivated in a temperate region of Europe, Asia, United States, India and Mediterranean countries due to their commercial value and distinct aroma. In addition to traditional food flavouring uses, M. × piperita is well recognized for their traditional use to treat fever, cold, digestive, anti‐viral, anti‐fungal and oral mucosa and throat inflammation. The scientific studies provide awareness on the use of M. × piperita for biological effects such as anti‐oxidant, anti‐microbial, anti‐viral, anti‐inflammatory, biopesticidal, larvicidal, anticancer, radioprotective effect, genotoxicity and anti‐diabetic activity have been ascribed. A wide spectrum of bioactive phytochemicals such as flavonoids, phenolics lignans and stilbenes and essential oils are expected to be responsible for the aroma effects. In this sense, this present review provides an extensive overview of the traditional medicinal, phytochemical and multiple biological activities of this “Peppermint. ”
The role of online videos in teaching procedural skills to post-graduate medical learners: A systematic narrative review

Abstract Objective: Online videos are commonly used in medical education. The aim of this review was to investigate the role of online instructional videos in teaching procedural skills to postgraduate medical learners. Methods: This systematic narrative review was conducted according to the PRISMA guidelines. MEDLINE, Cochrane Central Register of Controlled Trials, EMBASE, ERIC and Google Scholar were searched. Full texts that applied to online videos, postgraduate medical learners and procedural skills were included without language restrictions. The methodological quality of the studies was evaluated using a validated tool. A thematic analysis of the studies was carried out using a general inductive approach. Results: A total of 785 articles were retrieved and the full text was reviewed for 66 articles that met the inclusion and exclusion criteria of the study. Twenty papers that were relevant to the role of online videos in postgraduate medical education of procedural skills were used for this review. They were heterogenous in the outcomes collected and the evidence was of variable quality. There was strong evidence for the use of online videos for procedural skill knowledge acquisition and retention. Online videos were used for various purposes, such as supervision, assessment, postoperative debriefing, providing feedback, and promoting reflection. Conclusion: Online videos are a valuable educational tool especially for procedural skill knowledge acquisition and retention. Future research needs to be carried out on the appropriate use of platforms in disseminating and using online videos, identifying the factors surrounding the learners, video characteristics, and data protection.
Preeclampsia - abdominal hypertension syndrome in pregnancy. whether a hypothesis will become a theory?

Based on the analysis of literature and their own data the authors presented modern aspects of the etiology and pathogenesis of preeclampsia from the perspective of intra-abdominal hypertension syndrome. The data are collected from a large representative sample of 647 patients at various stages of gestation. It was shown that elevated levels of intra-abdominal pressure at 20-24 weeks of pregnancy in some cases preceded the development of preeclampsia. The level of intra-abdominal pressure, preceding the development of preeclampsia in pregnant women with obesity, was significantly higher than that of normal-weight patients (p <0.001). Along with the level of intra-abdominal pressure, the rate of its increase plays an important role in the preeclampsia development, with a greater degree than the absolute value of the intra-abdominal pressure. Pregnant women with a rapid and substantial increase in intra-abdominal pressure (more than 4 mm Hg for 2 weeks of gestation) are more likely to have complications of pregnancy than patients with an increase in intra-abdominal pressure less then 2 mm Hg in a given time interval (p <0.001), while the higher the increase in intra-abdominal pressure, at the earlier stages complication develops. The article also provides information about the dynamics of intra-abdominal pressure during pregnancy, relationships of intra-abdominal hypertension with parameters of utero-placental blood flow, renal hemodynamics, intestinal perfusion and permeability, level of endotoxemia in pregnant women. Based on the results of their own investigations, the authors suggest a model of preeclampsia development as a consequence of intra-abdominal hypertension syndrome.
New results on state estimation and stability analysis based H∞ control for multi-delay hybrid stochastic neural network

This paper researches the stability and stabilisation problems of stochastic neural network with multiple time delays. As for time delay, neuron state delay is first introduced in this paper. The neuron state delay and the activation function delay are considered simultaneously, which improves system performance effectively. Due to that part of the state is unmeasurable, this paper designs an observer for the observation of state information. By constructing an appropriate Lyapunov–Krasovskii functional and employing a method of combining free weighting matrix and integral inequality, an observer-based stability criterion is obtained. The conservativeness of delay upper bound is reduced actively. At last, a controller is designed for the stochastic neural network. Numerical examples are given to prove the effectiveness of the results.
Validation of Shock Index Pediatric-Adjusted for children injured in warzones

BACKGROUND Shock Index Pediatric-Adjusted (SIPA) has been used to predict injury severity and outcomes after civilian pediatric trauma. We hypothesize that SIPA can predict the need for blood transfusion and emergent surgery among pediatric patients injured in warzones, where resources are limited and accurate triage is essential. METHODS Retrospective review of the DoD Trauma Registry for all patients 17 years or younger, from 2008 to 2015. Shock Index Pediatric-Adjusted was determined using vital signs recorded upon arrival to the initial level of care. Patients were classified into two groups (normal vs. elevated SIPA) using age-specific threshold values. The need for blood product transfusion (BPT) within 24 hours and emergent surgical procedures (ESP) was compared between groups. Intensive care unit admission, injury severity, and mortality were also compared. Regression analysis was performed to evaluate the relationship between SIPA and primary outcomes. RESULTS There were 2,121 patients included with a mean Injury Severity Score of 12 ± 10. The mechanism of injury was penetrating (63%), blunt (25%), and burns (12%). Patients with an elevated SIPA (43%) had a significantly greater need for BPT (49.2% vs. 25.0%) and ESP (22.9% vs. 16.0%), as well as mortality (10.3% vs. 4.8%) and intensive care unit admission (49.9% vs. 36.1%), all p less than 0.001. Regression analysis confirmed an elevated SIPA as independently associated with both BPT (odds ratio, 2.36; 95% confidence interval, 1.19–2.94; p < 0.001) and ESP (odds ratio, 1.29; 95% confidence interval, 1.01–1.64; p = 0.044). CONCLUSION This is the first study of SIPA in pediatric warzone trauma. Elevated SIPA is associated with significantly increased need for BPT and emergent surgery and may therefore serve as a valuable tool for planning and triage in austere settings. LEVEL OF EVIDENCE Prognostic/epidemiological, Level III.
Endoscopic Versus Percutaneous Preoperative Biliary Drainage in Patients With Klatskin Tumor Undergoing Curative Surgery: A Systematic Review and Meta-Analysis of Short-Term and Long-Term Outcomes

Aims. To compare short-term and long-term outcomes of preoperative endoscopic biliary drainage (EBD) and percutaneous biliary drainage (PBD) in patients with Klatskin tumor undergoing curative surgery. Methods. We conducted a search of electronic information sources to identify all studies comparing EBD and PBD in patients with Klatskin tumor undergoing curative surgery. We used the Newcastle-Ottawa Scale to assess the risk of bias observational studies. Random-effects or fixed-effects modeling was applied as appropriate to calculate pooled outcome data. Results. We identified 9 observational studies, enrolling a total of 1436 patients. The patients in the PBD group had more advanced disease than those in EBD group in terms of Bismuth-Corlette classification and tumor classification. EBD was associated with higher risks of postprocedural complications (odds ratio [OR] =2.24, P = .001), conversion to another drainage method (OR =11.16, P < .00001), cholangitis (OR = 4.58, P < .0001), and pancreatitis (OR = 8.90, P = .009) than PBD; there was no difference between the 2 methods in terms of technical success (OR = 0.79, P = .50) and tube dislocation (OR = 0.81, P = .54). Regarding the postoperative outcomes, there was no difference in terms of 30-day mortality (OR = 0.61, P = .16) and major postoperative complications (OR = 0.60, P = .06). Regarding the long-term outcomes, EBD was associated with lower risks of seeding metastasis (OR = 0.46, P = .0004) and 5-year recurrence (OR = 0.72, P = .010), and better 5-year survival (OR = 1.62, P = .001). Conclusions. EBD may be associated with higher procedure-related complications compared with PBD as a preoperative biliary drainage method in patients with Klatskin tumor undergoing curative surgery. The available evidence on long-term oncological and survival outcomes are subject to confounding by indication, and high-quality randomized controlled trials are required for definite conclusions.
Effects of tapering on neuromuscular and metabolic fitness in team sports: a systematic review and meta-analysis

Abstract Purpose: To assess the effects of a taper strategy on neuromuscular and metabolic fitness in team sport athletes, through a systematic review and meta-analysis. Method: To be included in this meta-analysis, studies had to involve competitive team sport athletes and a tapering intervention providing details about the procedures used to decrease the training load, as well as competition or field-based criterion performance and all necessary data to calculate effect sizes. Four databases were searched according to these criteria, which led to the identification of 895 potential studies and the subsequent inclusion of 14 articles. Independent variables were training intensity, volume and frequency, as well as the pattern of taper and its duration. The dependent variable was performance obtained in various neuromuscular and metabolic tests. Results: There was limited evidence of a moderate taper-induced improvement in repeated sprint ability (Standardized Mean Difference (SMD) (95%IC;I2) = 0.41 (0.26–0.55;0%)) and moderate evidence of a moderate increase in maximal power (SMD (95%IC;I2) = 0.44 (0.32–0.56;15%)), change of direction speed (SMD (95%IC;I2) = 0.38 (0.15–0.60;28%)) and maximal oxygen uptake (SMD (95%IC;I2) = 0.76 (0.43–1.09;37%)). Conclusion: Tapering is an effective training strategy to improve maximal power, maximal oxygen uptake, repeated sprint ability and change of direction speed in team sports. However, the literature lacks studies using various tapering strategies to compare their effectiveness and make evidence-based recommendations. Future original studies should focus on this major issue.
Predictive factors of the lupus nephritis in a Tunisian cohort.

INTRODUCTION Renal involvement is a common and serious manifestation of systemic lupus erythematosus (SLE) and it is life-threatening. AIM To identify the predictive factors of the lupus nephritis (LN). METHODS A descriptive, analytical, single-centre, retrospective study of 115 patients with SLE (ACR 1997) was carried out in an internal medicine department for a period of 20 years from 1997 until 2017. LN was diagnosed by proteinuria ≥ 0.5 g /24h and / or urine sediment abnormality. Eighty patients did not have kidney damage during the follow-up and thirty-five developed renal involvement after SLE diagnosis. RESULTS The univariate analysis retained several epidemiological, clinical and biological correlation parameters, according to the development of lupus nephritis, statistically significant. They are as follows, the male gender, the age of diagnosis of SLE less than or equal to 34 years, the presence of malar rash by the time of SLE diagnosis, naso/pharyngeal ulcerations, leucopoenia, positivity of anti-Sm antibody and low C3 complement.The multivariate analysis had found that age less than or equal to 34 years at the diagnosis of the SLE was the only predictive factor of the onset of LN (OR=5.1 and HR=3.4). CONCLUSION Given the seriousness of the pathology and the complexity of its management, LN should be detected as soon as possible and must be treated appropriately by selecting the lupus population at risk for developing a serious LN.
A Call for the Application of Patient Safety Culture in Medical Humanitarian Action: A Literature Review

Supplemental digital content is available in the text. Objectives The aims of the study were to assess lessons learned on patient safety in Organization for Economic Cooperation and Development (OECD) countries and to assess whether they are applied or can be applied to the humanitarian medicine. Methods This is (a) a 2013–2018 rapid literature review of reviews and systematic reviews articles (PubMed database) on “patient safety” and “medical error” to look for lessons learned regarding patient safety in OECD countries and (b) a rapid literature review (PubMed and Embase databases) on “humanitarian medicine” and “patient safety,” from their creation to 2018, to find any articles related to patient safety in humanitarian medicine. In both reviews were excluded articles specifically related to one device, disease, or medical act. These reviews were complemented by a Google search. Results Of the 245 references retrieved, 104 met the inclusion criteria. Of 308 references, 39 respected the inclusion criteria. In OECD countries, patient safety comprises correlated measures taken at three levels. The micro level focuses on individual staff involved in healthcare provision or management; the meso level focuses on medical institutions; the macro level focuses on national healthcare systems. Only one reference mentioned the implementation of a medical error reporting and analysis system in medical humanitarian organization. Conclusions The adoption of strategies and a culture of safety will need to be adapted to address the variety of intervention contexts and to respond first to the fears and expectations of humanitarian staff. Medical humanitarian organizations, in the absence of an overarching authority for the sector, have a major responsibility in the development of a general patient safety policy applicable in all their operations.
Current concepts and management

OBJECTIVE To inform primary care physicians about current issues around generalized convulsive status epilepticus (GCSE) emphasizing deﬁnition, pathophysiology, treatment, and prognosis. QUALITY OF EVIDENCE MEDLINE (1994 to 1999) provided 479 references using the MeSH terms “status epilepticus” and “treatment. ” From these we selected 30 English-language articles covering clinical aspects, treatment, and animal research. Key source documents from previous years and information from modern textbooks and recent symposia were also included. combined lorazepam and phenytoin the initial treatment of choice. Other preferred are diazepam, midazolam, and propofol. Some of these medications should be considered before arrival at hospital. Prognosis of GCSE is determined by underlying cause, delay in adequate treatment, and comorbidity. GCSE longer than 30 intensive and electroencephalogram electroencephalographic (EEG) monitoring in intensive care can lower morbidity and mortality. 25
THE AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The second page should carry an abstract of not more than 200 words, written as a single paragraph. It should be written for the readership of both clinicians and basic investigators and should state the hypothesis or central question of the study or investigation, the study subjects or experimental animals, observational and analytical methods, the main findings, and a final statement of the principal conclusions. Use only approved abbreviations.
Evaluation of Myc Gene Expression as a Preventive Marker for Increasing the Implantation Success in the Infertile Women

Background: There are numerous couples worldwide currently suffering from infertility. Several factors, including genetic abnormalities are involved in infertility. In this study, we investigated the expression of myc gene in uterine tissue of infertile women. The protein encoded by this gene is one of the important transcription factors involved in the expression of many genes in the embryonic growth, and development pathways. Methods: There are about 45 samples of uterine tissue from women with primary and secondary infertility were involved in this study. After extracting RNA and synthesizing cDNA, using specific primers for the myc gene and the beta-actin gene (as an internal control), gene expression was evaluated by Real-time RT-PCR method. Results: The results of myc gene expression analysis showed no significant pattern between the affected and healthy women, however decreasing of its expression should not be rejected. Conclusions: This study is the first report about myc gene expression and its relation with the primary and secondary infertility. Myc gene expression study at different times of sexual period of infertile woman is suggested. Also, we proposed here, as a preventive strategy, improvement of the expression level of myc gene by some methods, such as hormone therapy, can increase the implantation success in the infertile women.
Machine Learning Diagnostic Modeling for Classifying Fibromyalgia Using B-mode Ultrasound Images

Fibromyalgia (FM) diagnosis remains a challenge for clinicians due to a lack of objective diagnostic tools. One proposed solution is the use of quantitative ultrasound (US) techniques, such as image texture analysis, which has demonstrated discriminatory capabilities with other chronic pain conditions. From this, we propose the use of image texture variables to construct and compare two machine learning models (support vector machine [SVM] and logistic regression) for differentiating between the trapezius muscle in healthy and FM patients. US videos of the right and left trapezius muscle were acquired from healthy (n = 51) participants and those with FM (n = 57). The videos were converted into 64,800 skeletal muscle regions of interest (ROIs) using MATLAB. The ROIs were filtered by an algorithm using the complex wavelet structural similarity index (CW-SSIM), which removed ROIs that were similar. Thirty-one texture variables were extracted from the ROIs, which were then used in nested cross-validation to construct SVM and elastic net regularized logistic regression models. The generalized performance accuracy of both models was estimated and confirmed with a final validation on a holdout test set. The predicted generalized performance accuracy of the SVM and logistic regression models was computed to be 83.9 ± 2.6% and 65.8 ± 1.7%, respectively. The models achieved accuracies of 84.1%, and 66.0% on the final holdout test set, validating performance estimates. Although both machine learning models differentiate between healthy trapezius muscle and that of patients with FM, only the SVM model demonstrated clinically relevant performance levels.
Novel Oral Anticoagulant and Efficacy on Atrial Fibrillation Patients

ABSTRACT Atrial fibrillation is the most common Cardiac arrhythmia and the third major cause of death in elderly. Atrial fibrillation is considered as a major cause for stroke in UK and England. Atrial fibrillation (AF) is associated with stroke due to thromboembolism. Atrial fibrillation is affecting more than 600,000 people all over world. Warfarin is the first anticoagulant which was used for atrial fibrillation patient. There is need for proper patient care and safety regulation while using warfarin, since there is risk of blood clotting in more for patients using warfarin. Novel Oral Anticoagulants (NOACs) which are new class of anticoagulant drugs and used instead of warfarin due to less risk of blood clotting in patients. Apixaban, Dabigatran and Rivaroxaban are most commonly used NOACs drugs. This review article gives complete description about efficacy and comparative use of Anti-coagulants and Novel Oral Anticoagulants in Atrial fibrillation patients having risk of stroke. It mainly focuses on use of NOACs in place of warfarin which is safe to use.
Development of an individualized asynchronous sensor-based telerehabilitation program for patients undergoing total knee replacement: Participatory design

Telerehabilitation programs can be employed to establish communication between patients and healthcare professionals and empower patients performing their training remotely. This study aimed to identify patients’ requirements after a total knee replacement following a self-training rehabilitation program, leading to the design and development of a telerehabilitation program that can meet the stakeholders’ actual needs. System design, development, and testing were conducted in five iterations based on a participatory design approach. Data collection was performed using interviews, observations, prototyping, and questionnaires. It was found that the main barriers facing the existing rehabilitation program were a lack of clear communication, lack of relevant information, and healthcare professional’s feedback. The participants emphasized the main themes of communication, information, training, and motivation in the process of design and development. In using the telerehabilitation program, the patients reported a high level of user-friendliness, flexibility, and a sense of security. This study has identified obstacles in the current rehabilitation program and revealed the potential effectiveness of using asynchronous communication and sensor-based technologies by employing participatory design and development. A higher level of portability and flexibility were observed. However, future studies and development are required to investigate the overall usability and reliability of the telerehabilitation program.
Gene therapy beyond luxturna: a new horizon of the treatment for inherited retinal disease.

PURPOSE OF REVIEW Gene therapy offers, for the first time, the possibility to cure diseases such as retinitis pigmentosa. The positive outcomes that led to the U.S. Food and Drug Administration (FDA) approval of Luxturna to treat Leber congenital amaurosis caused by RPE65 mutations created an optimistic atmosphere in the research, clinical and patient community. Despite this first success, we must understand that this is not a 'one treatment for all'. This review aims to explain the basic concepts of gene therapy and how they translate in different approaches that are utilized in ongoing clinical trials here reviewed. RECENT FINDINGS In 2017, the FDA approved the first gene therapy treatment. In parallel, other approaches have gained attention. Different delivery methods (adeno-associated virus, lentivirus), injection sites (subretinal, intravitreal, suprachoroidal) and methodologies (gene replacement, silencing, editing) are currently being tested. SUMMARY Gene therapy is an evolving field in medicine and ophthalmology. Its success and application depends on several factors that are specific to the disease to treat. For now, we know it's a relatively safe approach and we look forward to the continued advancements of current ongoing clinical trials.