Miracle-dz/UniFAR-FTUs huggingface dataset:
Preservation Effects on Stable Isotope Values of Archived Elasmobranch Fin Tissue: Comparisons between Frozen and Ethanol-Stored Samples

AbstractElasmobranch fin tissue has been sampled and archived for decades to support genetics research. However, these collections have the potential to provide additional information on the trophic ecology of and habitat use by elasmobranch species. The use of fin tissue is especially attractive considering the threatened status of many elasmobranchs and the call for limiting mortalities. Yet, the use of fin samples for stable isotope analysis requires either that (1) storage methods do not alter tissue isotope values or (2) any alterations in isotope composition that occur during storage are predictable. In this study, paired fin tissues sampled from Smalltooth Sawfish Pristis pectinata and cownose rays Rhinoptera spp. were stored frozen and in ethanol and were subsequently analyzed for carbon (δ13C) and nitrogen (δ15N) isotope ratios. Fin δ13C and δ15N values were highly correlated between treatments for both taxa (r2 ≥ 0.80). For Smalltooth Sawfish, ethanol storage significantly increased fin δ13C val.
Unrestricted evening use of light‐emitting tablet computers delays self‐selected bedtime and disrupts circadian timing and alertness

Consumer electronic devices play an important role in modern society. Technological advancements continually improve their utility and portability, making possible the near‐constant use of electronic devices during waking hours. For most people, this includes the evening hours close to bedtime. Evening exposure to light‐emitting (LE) devices can adversely affect circadian timing, sleep, and alertness, even when participants maintain a fixed 8‐hour sleep episode in darkness and the duration of evening LE‐device exposure is limited. Here, we tested the effects of evening LE‐device use when participants were allowed to self‐select their bedtimes, with wake times fixed as on work/school days. Nine healthy adults (3 women, 25.7 ± 3.0 years) participated in a randomized and counterbalanced study comparing five consecutive evenings of unrestricted LE‐tablet computer use versus evenings reading from printed materials. On evenings when using LE‐tablets, participants' self‐selected bedtimes were on average half an hour later (22:03 ± 00:48 vs. 21:32 ± 00:27 h; P = 0.030), and they showed suppressed melatonin levels (54.17 ± 18.00 vs. 9.75 ± 22.75%; P < 0.001), delayed timing of melatonin secretion onset (20:23 ± 01:06 vs. 19:35 ± 00:59 h; P < 0.001), and later sleep onset (22:25 ± 00:54 vs. 21:54 ± 00:25 h; P = 0.041). When using LE‐tablets, participants rated themselves as less sleepy in the evenings (P = 0.030) and less alert in the first hour after awakening on the following mornings (P < 0.001). These findings demonstrate that evening use of LE‐tablets can induce delays in self‐selected bedtimes, suppress melatonin secretion, and impair next‐morning alertness, which may impact the health, performance, and safety of users.
Nutrition Society Medal Lecture A heliocentric view of leptin

Abbreviations: OB-R, leptin receptor; SNAP, S-nitroso-N-acetyl-penicillamine; STAT, signal transducers and activators of transcription. Corresponding author: Dr Gema Frühbeck, fax +34 948 29 65 00, email gfruhbeck@unav.es CAB InternationalPNSProceedings of the Nutrition Society (2001)© Nutrition Society 2001 60 PNS00-096Nutrition ociety Medal LectureG. Frühbeck301 318 © Nutri io Soc ety 2001 The Summer Meeting of the Nutrition Society was held at University College, Cork, Republic of Ireland on 2730 June 2000
3 D Scene Reconstruction from Multiple Uncalibrated Views

In this project, we focus on the problem of 3D scene reconstruction from multiple uncalibrated views. We have studied different 3D scene reconstruction methods, including Structure from Motion (SFM) and volumetric stereo (space carving and voxel coloring). Here we report the results of applying these methods to different scenes, ranging from simple geometric structures to complicated buildings, and will compare the performances of different methods.
Laser-induced ultrafast spin dynamics in ErFeO 3

Using 100-fs optical laser pulses, we have been able to excite and probe spin dynamics in the rare-earth orthoferrite ${\mathrm{ErFeO}}_{3}$. The investigation was performed in a broad temperature range with the focus on the vicinities of the compensation point ${T}_{\mathrm{comp}}\ensuremath{\approx}47\phantom{\rule{0.16em}{0ex}}\mathrm{K}$ and the spin reorientation transition region in the interval $86\phantom{\rule{0.16em}{0ex}}\mathrm{K}\ensuremath{\lesssim}T\ensuremath{\lesssim}99\phantom{\rule{0.16em}{0ex}}\mathrm{K}$. Spin precession excited by the laser pulse was present in a large part of the investigated temperature range, but was especially strong near the spin reorientation region. In this region the laser pulse also caused an ultrafast spin reorientation. By changing the laser pulse fluence, we could vary both the reorientation amplitude and the reorientation speed. We show that the laser-induced spin dynamics in ${\mathrm{ErFeO}}_{3}$ is caused in part by heating and in part by the inverse Faraday effect. Comparing to the results of similar experiments in other rare-earth orthoferrites, we found the speed of the laser-induced spin reorientation to be significantly lower. We attribute this finding to the weaker electron-phonon coupling of the ${\mathrm{Er}}^{3+}$ 4f electrons with the lattice.
Standardized Duplex Ultrasound-Based Protocol for Early Diagnosis of Transplant Renal Artery Stenosis: Results of a Single-Institution Retrospective Cohort Study

Transplant renal artery stenosis (TRAS) is the most frequent vascular complication after kidney transplantation (KT) and has been associated with potentially reversible refractory hypertension, graft dysfunction, and reduced patient survival. The aim of the study is to describe the outcomes of a standardized Duplex Ultrasound- (DU-) based screening protocol for early diagnosis of TRAS and for selection of patients potentially requiring endovascular intervention. We retrospectively reviewed our prospectively collected database of KT from January 1998 to select patients diagnosed with TRAS. The follow-up protocol was based on a risk-adapted, dynamic subdivision of eligible KT patients in different risk categories (RC) with different protocol strategies (PS). Of 598 patients included in the study, 52 (9%) patients had hemodynamically significant TRAS and underwent percutaneous angioplasty (PTA) and stent placement. Technical and clinical success rates were 97% and 90%, respectively. 7 cases of restenosis were recorded at follow-up and treated with re-PTA plus stenting. Both DU imaging and clinical parameters improved after stent placement. Prospective high-quality studies are needed to test the efficacy and safety of our protocol in larger series. Accurate trial design and standardized reporting of patient outcomes will be key to address the current clinical needs.
Interferencias dos meios de comunicacao no nosso conhecimento

Os meios de comunicacao, principalmente a televisao, desenvolvem formas sofisticadas de comunicacao sensorial, multidimensional, integrando linguagens, ritmos e caminhos diferentes de acesso ao conhecimento. As formas de contar sao mais variadas, menos racionais, mais sensoriais-afetivas; a organizacao do conhecimento e menos precisa, mais intuitiva. As abordagens das ideias oscilam entre o maniqueismo dogmatico e uma ambiguidade etica, o qual permite alto grau de entropia, de interferencias por parte de concessionarios, produtores e consumidores e interfere profundamente na comunicacao de outros espacos educacionais como o escolar, o familiar e o religioso.
Molecular and Cellular Pathogenesis of Endometriosis

Background: A substantial body of studies supports the view that molecular and cellular features of endometriotic lesions differ from those of eutopic endometrium. Apart from that, evidence exists that the eutopic endometrium from pa-tients with endometriosis differs from that of females without endometriosis. Objective: Aberrant expression profiles include a number of non-steroid signaling pathways that exert their putative influ-ence on the pathogenesis of endometriosis at least in part via crosstalk(s) with estrogen-mediated mechanisms. A rational to focus research on non-steroid signal pathways is that they might be remunerative targets for the development and selection of novel therapeutics to treat endometriosis possibly without affecting estrogen levels. Results and Conclusion: In this article, we describe molecular and cellular features of endometriotic lesions and focus on the canonical WNT/β-signaling pathway, a key regulatory system in biology (including stem cell homeostasis) and often in pathophysiological conditions such as endometriosis. Recently emerged novel biological concepts in signal transduction and gene regulation like exosomes and microRNAs are discussed in their putative role in the pathogenesis of endometriosis.
Connecting Distant Entities with Induction through Conditional Random Fields for Named Entity Recognition: Precursor-Induced CRF

This paper presents a method of designing specific high-order dependency factor on the linear chain conditional random fields (CRFs) for named entity recognition (NER). Named entities tend to be separated from each other by multiple outside tokens in a text, and thus the first-order CRF, as well as the second-order CRF, may innately lose transition information between distant named entities. The proposed design uses outside label in NER as a transmission medium of precedent entity information on the CRF. Then, empirical results apparently demonstrate that it is possible to exploit long-distance label dependency in the original first-order linear chain CRF structure upon NER while reducing computational loss rather than in the second-order CRF.
Comparison of organically and conventionally produced Batavia type lettuce stored in modified atmosphere packaging for postharvest quality and nutritional parameters.

BACKGROUND The impacts of organic and conventional production systems on postharvest life and quality parameters of Batavia type 'Caipira' lettuce heads (Lactuca sativa L.) were investigated. Harvested lettuce heads grown in two different production systems were stored at 0 °C temperature and 95-98% relative humidity for 20 days in modified atmosphere packaging. RESULTS The lowest weight loss, the highest ascorbic acid content and antioxidant activity were obtained from the organic production system (Org-2). The conventional production system had higher total soluble solids, titratable acidity, and total phenolic contents. During the shelf-life period at 20 °C, the weight losses of lettuce heads grown conventionally were higher than with the other production system. Conventionally grown heads had higher titratable acidity and total phenolic contents than organically grown heads. The highest titratable acidity and h° values were obtained from the plants grown under conventional and organic production systems (Org-2), while the highest chroma value and antioxidant activity were detected from the control treatment. The highest ascorbic acid content was detected in the control treatment, but the effects of control, organic (Org-2) and conventional production systems on ascorbic acid content were not statistically significant. CONCLUSION The results indicated that the organic production system (Org-2) was the most effective treatment in prolonging postharvest life and protecting the quality of Batavia type 'Caipira' lettuce heads stored in modified atmosphere packaging. © 2018 Society of Chemical Industry.
Model Communities Hint at Promiscuous Metabolic Linkages between Ubiquitous Free-Living Freshwater Bacteria

Genome streamlining is frequently observed in free-living aquatic microorganisms and results in physiological dependencies between microorganisms. However, we know little about the specificity of these microbial associations. ABSTRACT Genome streamlining is frequently observed in free-living aquatic microorganisms and results in physiological dependencies between microorganisms. However, we know little about the specificity of these microbial associations. In order to examine the specificity and extent of these associations, we established mixed cultures from three different freshwater environments and analyzed the cooccurrence of organisms using a metagenomic time series. Free-living microorganisms with streamlined genomes lacking multiple biosynthetic pathways showed no clear recurring pattern in their interaction partners. Free-living freshwater bacteria form promiscuous cooperative associations. This notion contrasts with the well-documented high specificities of interaction partners in host-associated bacteria. Considering all data together, we suggest that highly abundant free-living bacterial lineages are functionally versatile in their interactions despite their distinct streamlining tendencies at the single-cell level. This metabolic versatility facilitates interactions with a variable set of community members.
Bacterial regulatory RNAs: complexity, function, and putative drug targeting

Abstract Over the past decade, RNA-deep sequencing has uncovered copious non-protein coding RNAs (npcRNAs) in bacteria. Many of them are key players in the regulation of gene expression, taking part in various regulatory circuits, such as metabolic responses to different environmental stresses, virulence, antibiotic resistance, and host-pathogen interactions. This has contributed to the high adaptability of bacteria to changing or even hostile environments. Their mechanisms include the regulation of transcriptional termination, modulation of translation, and alteration of messenger RNA (mRNA) stability, as well as protein sequestration. Here, the mechanisms of gene expression by regulatory bacterial npcRNAs are comprehensively reviewed and supplemented with well-characterized examples. This class of molecules and their mechanisms of action might be useful targets for the development of novel antibiotics. Graphical Abstract
Identification of Nutritional Components in Black Sesame Determined by Widely Targeted Metabolomics and Traditional Chinese Medicines

Chemical composition of secondary metabolites is of great importance for quality control of agricultural products. Black sesame seeds are significantly more expensive than white sesame seeds, because it is thought that black sesame seeds are more beneficial to human health than white sesame seeds. However, the differences in nutrient composition between black sesame seeds and white sesame seeds are still unknown. The current study examined the levels of different metabolites in black and white sesame seeds via the use of a novel metabolomics strategy. Using widely targeted metabolomics data, we obtained the structure and content of 557 metabolites, out of which 217 metabolites were identified, and discovered 30 metabolic pathways activated by the secondary metabolites in both black and white sesame seeds. Our results demonstrated that the main pathways that were differentially activated included: phenylpropanoid biosynthesis, tyrosine metabolism, and riboflavin metabolism. More importantly, the biomarkers that were significantly different between black seeds and white sesame seeds are highly related to the functions recorded in traditional Chinese medicine. The results of this study may serve as a new theoretical reference for breeding experts to promote the genetic improvement of sesame seeds, and therefore the cultivation of higher quality sesame varieties.
Does Hormone Therapy Use Increase Perioperative Complications in Abdominally Based Microsurgical Breast Reconstruction?

Background: The use of hormone therapy (tamoxifen and aromatase inhibitors) has been shown to increase venous thromboembolism. As breast cancer patients undergoing microsurgical breast reconstruction are often receiving hormone therapy, it is unclear whether this increased thrombotic risk is associated with increased flap loss. Methods: A retrospective review was performed on patients undergoing abdominally based microsurgical breast reconstruction at an academic institution from 2004 to 2015. Patients were divided by use of hormone therapy at the time of surgery. Complication rates, including complete or partial flap loss and overall complications, were compared and analyzed using univariate and logistic regression models. Results: Among a total of 853 patients (1253 flaps), 193 patients (269 flaps) were receiving hormone therapy and 660 patients (984 flaps) were not. Patients on hormone therapy had higher rates of previous breast surgery, advanced cancer stage, chemoradiation before reconstruction, and delayed and unilateral reconstruction. There were no statistically significant differences between hormone therapy patients and nontherapy patients in complete flap loss (1.0 percent versus 1.1 percent) and partial flap loss (2.2 percent versus 1.5 percent). Hypertension and previous breast surgery were the only independent risk factors for minor complications (adjusted OR, 2.1; 95 percent CI, 1.3 to 3.6; p = 0.005; and adjusted OR, 1.8; 95 percent CI, 1.2 to 2.7; p = 0.009, respectively) and overall complications (adjusted OR, 2.2; 95 percent CI, 1.3 to 3.7; p = 0.004; and adjusted OR, 1.9; 95 percent CI, 1.3 to 3.0; p = 0.003, respectively). Conclusions: Hormone therapy was not associated with a higher incidence of complete or partial flap loss or overall complications. The authors propose an individualized approach to the preoperative cessation of tamoxifen or aromatase inhibitors. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.
Three steps to maintain predictable interdental papilla and gingiva emergence profiles in immediate implant placement. A 3-year follow-up case report

We present a case that describes a three-step clinical technique to provide guidelines to replace fractured teeth with immediate implant placement using the same dental structure as a temporary crown and a regenerative approach. This approach predictably maintains the interdental papilla and gingiva emergence profile to ensure a favorable cosmetic result. A 3-year follow-up has shown good clinical outcomes and stability in crestal bone levels. Consequently, this is an innovative way to do temporary crown and design restorations in everyday clinical practice. Key words:Interdental papilla, dental implant, inmmediate implant, gingival aesthetics, dental aesthetics.
Enhanced Tribological and Bacterial Resistance of Carbon Nanotube with Ceria- and Silver-Incorporated Hydroxyapatite Biocoating

Pertaining to real-life applications (by scaling up) of hydroxyapatite (HA)-based materials, herein is a study illustrating the role of carbon nanotube (CNT) reinforcement with ceria (CeO2) and silver (Ag) in HA on titanium alloy (TiAl6V4) substrate, utilizing the plasma-spraying processing technique, is presented. When compared with pure HA coating enhanced hardness (from 2.5 to 5.8 GPa), elastic modulus (from 110 to 171 GPa), and fracture toughness (from 0.7 to 2.2 MPa·m1/2) elicited a reduced wear rate from 55.3 × 10−5 mm3·N−1·m−1 to 2.1 × 10−5 mm3·N−1·m−1 in HA-CNT-CeO2-Ag. Besides, an order of magnitude lower Archard’s wear constant and a 41% decreased shear stress by for HA-CNT-CeO2-Ag coating depicted the effect of higher hardness and modulus of a material to control its wear phenomenon. Antibacterial property of 46% (bactericidal) is ascribed to Ag in addition to CNT-CeO2 in HA. Nonetheless, the composite coating also portrayed exaggerated L929 fibroblast cell growth (4.8 times more than HA), which was visualized as flat and elongated cells with multiple filopodial protrusions. Hence, synthesis of a material with enhanced mechanical integrity resulting in tribological resistance and cytocompatible efficacy was achieved, thereupon making HA-CNT-CeO2-Ag a scalable potent material for real-life load-bearing implantable bio-coating.
Persistent Infiltration and Impaired Response of Peripherally-Derived Monocytes after Traumatic Brain Injury in the Aged Brain

Traumatic brain injury (TBI) is a leading cause for neurological disabilities world-wide. TBI occurs most frequently among the elderly population, and elderly TBI survivors suffer from reduced recovery and poorer quality of life. The effect of age on the pathophysiology of TBI is still poorly understood. We previously established that peripherally-derived monocytes (CCR2+) infiltrate the injured brain and contribute to chronic TBI-induced cognitive deficits in young animals. Furthermore, age was shown to amplify monocyte infiltration acutely after injury. In the current study, we investigated the impact of age on the subchronic response of peripherally-derived monocytes (CD45hi; CCR2+) and their role in the development of chronic cognitive deficits. In the aged brain, there was a significant increase in the number of peripherally-derived monocytes after injury compared to young, injured animals. The infiltration rate of peripherally-derived monocytes remained elevated subchronically and corresponded with enhanced expression of CCR2 chemotactic ligands. Interestingly, the myeloid cell populations observed in injured aged brains had impaired anti-inflammatory responses compared to those in young animals. Additionally, in the aged animals, there was an expansion of the blood CCR2+ monocyte population after injury that was not present in the young animals. Importantly, knocking out CCR2 to inhibit infiltration of peripherally-derived monocytes prevented chronic TBI-induced spatial memory deficits in the aged mice. Altogether, these results demonstrate the critical effects of age on the peripherally-derived monocyte response during the progression of TBI pathophysiology.
Cutaneous Basal Cell Carcinoma with Lymph Node and Pulmonary Metastases

Basal cell carcinoma (BCC) is the most common skin cancer. Metastatic BCC is an extraordinary rare finding observed in only 0.5% of all cases. Until the introduction of the small molecule hedgehog inhibitor vismodegib, patients with metastatic BCC were treated with chemotherapy, most frequently platinum-based with mixed responses to therapy. We present the case of a 55-year-old Caucasian man who suffered from BCC on his left arm with lymph node and pulmonary metastases. Sonic hedgehog blockade with vismodegib only induced a short remission, and the patient succumbed to the cancer.
Asymptotical Cooperative Tracking Control for Unknown High-Order Multi-Agent Systems via Distributed Adaptive Critic Design

In this paper, a distributed adaptive critic design-based asymptotical cooperative tracking control scheme is established for a class of unknown high-order multi-agent systems with disturbances on undirected graphs. The cooperative tracking problem of high-order multi-agent systems is first transformed to the stabilizing problem of filtered tracking errors dynamic systems, which only depend on the information from neighboring agents. Then, a novel distributed adaptive critic design-based controller is developed for the newly obtained filtered tracking errors dynamic systems. The special local filtered tracking errors and local critic signals are defined for facilitating the implementation of distributed adaptive critic design. Novel distributed weights updating laws for critic neural networks, actor neural networks, and adaptive parameters are proposed. Furthermore, the RISE technique is introduced to suppress the external disturbances and neural network approximation errors. The asymptotical stability of a closed-loop system is demonstrated by using Lyapunov stability theory. Finally, a simulation example justifying the effectiveness of the proposed control scheme is given.