Miracle-dz/UniFAR-FTUs huggingface dataset:
Explotación de la pesquería de arrastre de camarón durante el período 1991-1999 en el Golfo de Nicoya, Costa Rica

En Costa Rica, la pesqueria del camaron que se lleva a cabo en el Golfo de Nicoya desde 1952 represento una de las mas importantes actividades economicas de la region. Sin embargo, la sobrepesca redujo los volumenes de captura al punto de impedir esta actividad comercial. Con el objetivo de evaluar su evolucion durante la pasada decada y compararla con los registros historicos de captura, se analizaron las estadisticas pesqueras oficiales comprendidas entre 1991 y 1999 para las especies de camaron que se capturan: dos especies de camaron blanco (Litopenaeus occidentalis y L. stylirostris), el camaron titi (Xiphopenaeus riveti), el camaron cafe (Farfantepenaeus californiensis), el camaron pinki (F. brevirostris) y el camaron fidel (Solenocera agassizi). Todas las especies analizadas presentaron un alto nivel de sobre-explotacion, lo que provoca un aumento en la demanda de reclutas de camaron requeridos para tratar de reponer a los que son capturados por la flota arrastre. En consecuencia, la edad de primera captura ha disminuido exponencialmente. Se recomienda vedar totalmente la pesca de arrastre del camaron en el Golfo de Nicoya.
Reorganizing the treatment of cardiovascular disease in response to coronavirus disease 2019; time for the polypill?

PURPOSE The coronavirus disease 2019 (COVID-19) pandemic has forced a redesign of healthcare services. Resource reallocation will have consequences on the routine management of chronic diseases, including cardiovascular disease (CVD). We consider how to mitigate potential adverse effects. RECENT FINDINGS Combination therapy is well established in hypertension. Many guidelines recommend dual antihypertensive therapy as the initial treatment step as this results in faster blood pressure control, albeit with limited evidence of improved outcomes. Control of CVD risk factors through multiclass combination therapy (the polypill) was proposed many years ago. This approach has not been adopted by Western healthcare systems despite improving surrogate outcomes. Recently, the PolyIran trials have demonstrated improved CVD outcomes without increased adverse events, in both primary and secondary prevention. SUMMARY The COVID-19 pandemic allows models of chronic healthcare to be rethought. Current practices are resource-intensive and there is a need to simplify titration and monitoring protocols in CVD. Moving toward the use of polypill combinations allied with telehealth consultations may be one solution.
Examining correlates of alcohol related condom-less sex among youth living in the slums of Kampala, Uganda

ABSTRACT This study examined factors associated with alcohol related condom-less sex (ARCS) among youth living in Kampala, Uganda. Analyses are based on 2014 cross-sectional survey data of urban service-seeking youth participating in a Uganda Youth Development Link (UYDEL) drop-in center. The analytic sample consisted of only youth reporting alcohol use (n = 347). Logistic regression analyses were computed to determine the factors associated with ARCS. In the bivariable analysis, ARCS was associated with being female (OR: 1.86; 95% CI: 1.21, 2.85), age of first drinking being between ages 13–16 (OR: 2.63; 95% CI: 1.42,4.86), age of first time drunk being between ages 13–16 (OR: 2.88; 95% CI: 1.47, 5.67), binge drinking (OR: 3.64; 95% CI: 2.21, 5.98), rape (OR: 2.69; 95% CI: 1.64, 4.41), sex work (OR: 5.91; 95% CI: 3.09, 11.29), and being able to refuse sex when intoxicated (OR: 1.69; 95% CI: 1.10, 2.61). In the multivariable analysis, ARCS was associated with binge drinking (AOR: 2.97; 95% CI: 1.71, 5.17) and sex work (AOR: 3.48; 95% CI: 1.62, 7.49). These findings emphasize unmet needs of this population. Strategies seeking to prevent teenage alcohol use, particularly delaying initial alcohol use, may be beneficial for reducing ARCS in this population.
Factors Associated With Predischarge Versus Postdischarge Scheduling for Early Follow-up Appointments.

BACKGROUND Per national guidelines, early follow-up appointments should be scheduled before discharge, but in previous research, appointments scheduled before discharge were not associated with appointment adherence. OBJECTIVES The purpose of this study was to determine whether patient, heart failure (HF), and hospital factors were associated with predischarge appointment scheduling. METHODS A secondary analysis of a medical record review included patients hospitalized for decompensated HF at 3 health system hospitals who had a scheduled office appointment post discharge at 14 days or less. Patient demographics, and social, HF, and hospital factors were studied for association with predischarge scheduling. RESULTS In multivariable modeling, the odds of having an appointment scheduled predischarge were based on 3 factors: nonwhite race, history of chronic renal insufficiency, and no admission within 14 days before HF hospitalization. CONCLUSIONS Appointment scheduling may be based on provider perceptions of readmission risk. Follow-up appointment scheduling practices should be based on systematic processes.
A‐kinase‐interacting protein 1 promotes EMT and metastasis via PI3K/Akt/IKKβ pathway in cervical cancer

Overexpression of A‐kinase‐interacting protein 1 (AKIP1) has been reported in prostate and breast cancers. Nevertheless, the clinical potential of AKIP1 during the development of cervical cancer (CC) remains unclear. A series of experiments involving BdU, colony formation, wound healing and cell invasion assays were performed to determine cell proliferation, migration and invasion, respectively. Gene expression changes were validated by qRT‐PCR, Western blotting and immunocytochemistry. We found that AKIP1 expression is increased in CC cell lines and tissue specimens from CC patients. The elevated AKIP1 expression in primary tumours was related to lymph node metastasis in CC patients. In addition, we observed that overexpression of AKIP1 promotes CC cell proliferation. Enhanced expression of AKIP1 facilitated the migration and invasion of CC cells by inducing NF‐κB‐dependent epithelial‐mesenchymal transition (EMT). Moreover, mechanistic investigations revealed that AKIP1 induced nuclear translocation and phosphorylation of the p65 NF‐κB subunit through the PI3K/Akt/IKKβ pathway. Conversely, enhanced expression of phosphatase and tensin homologue (PTEN) inhibited this signalling pathway and restored an epithelial phenotype to CC cells in the presence of overexpressed AKIP1. Our results indicate that AKIP1 promotes the EMT and metastasis in CC by activating NF‐κB signalling through the PI3K/Akt/IKKβ pathway, suggesting that AKIP1 could be a pivotal regulator of an EMT axis in CC. Significance of the study AKIP1 expression in the samples of CC patients and in in vitro tumour cell lines provides evidence that expression of AKIP1 in CC contributes to cancer progression. Our findings indicate that AKIP1 promotes the epithelial‐mesenchymal transition and metastasis in CC by activating NF‐κB signalling through the PI3K/Akt/IKKβ pathway, suggesting that AKIP1 is a pivotal regulator of an EMT axis in CC. AKIP1 could be implicated as a potential therapeutic target as well as a valuable biomarker for evaluating prognosis for patients with CC.
Quantifying the impact of Gambusia holbrooki on the extinction risk of the critically endangered red-finned blue-eye

Managing competing endangered and invasive species in spatially structured environments is challenging because it is often difficult to control invasive species without negatively impacting the endangered species. Effective management action requires an understanding of the factors affecting the presence and absence of each species so that promising sites for relocation of endangered species combined with eradication of invasive species can be identified. We investigate competing hypotheses about the factors affecting occupancy of the critically endangered red-finned blue-eye (Scaturiginichthys vermeilipinnis; hereafter ‘RFBE'), a native Australian fish with a global distribution that is restricted to a group of shallow artesian springs. RFBE are threatened by competition with invasive mosquito fish (Gambusia holbrooki), which are steadily colonizing the springs, resulting in local extinctions of RFBE in most cases. While hypotheses about the influences of Gambusia on RFBE exist, none have been tested wit.
Effects of Gluteal Muscles Strengthening on Lower-Limb Injuries in Male Professional Handball Players: A Preliminary Study

Abstract Raya-González, J, García-Esteban, S, Hume, P, and Castillo, D. Effects of gluteal muscles strengthening on lower-limb injuries in male professional handball players: a preliminary study. J Strength Cond Res 35(6): 1593–1598, 2021—This study aimed to analyze the effects of a strength training injury-prevention program (STIPP) on injuries associated with weakness of the gluteal muscles in professional handball players. Twenty-seven professional Spanish male handball players from the same club, who competed at the Spanish Second National League level, participated in this study. The investigation was conducted over 2 consecutive seasons (2017–2018 and 2018–2019). The first season served as the control season (n = 21), and the second season served as the experimental season (n = 20). The STIPP was conducted 2 times per week, for 32 weeks, during the in-season period. There were no significant improvements in the injury incidence, pattern, or type for the experimental season group compared with the control season group (injury rate ratio [IRR] = 1.47; 95% confidence interval [CI]: 0.84–2.58; p = 0.17). However, there was a meaningful reduction in the number and burden of lumbar injuries after the STIPP (IRR = 55.83; 95% CI: 0.11–89.01; p = 0.001). In addition, burden values (number of absence days/1000 hours exposure) in all injury pathologies were lower during the experimental season compared with the control season. The STIPP focused on the gluteal muscles could be effective in reducing the number and burden of lumbar injuries in professional handball players.
Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH rats

ABSTRACT The study investigates how surgery during pregnancy, i.e., sham operation associated with embryo transfer, affects hypertensive phenotype in ISIAH rats genetically predisposed to hypertension. ISIAH rats born after maternal surgery at fourth day of pregnancy were compared with naturally conceived controls. Surgery during pregnancy in ISIAH rats caused acceleration of neurodevelopment in young offspring, as well as aggravating hypertension, suppressing exploratory activity, reducing hippocampal BDNF expression, and compensatory increasing of hippocampal neuronal density in adult ISIAH offspring. Maternal surgery during early pregnancy caused alterations in offspring phenotype in hypertensive ISIAH rat model.
In-vivo differentiation of adult hematopoietic stem cells from a single-cell point of view.

PURPOSE OF REVIEW Although hematopoietic stem cell (HSC) function has long been studied by transplantation assays, this does not reflect what HSCs actually do in their native context. Here, we review recent technologic advances that facilitate the study of HSCs in their native context focusing on inducible HSC-specific lineage tracing and inference of hematopoietic trajectories through single-cell RNA sequencing (scRNA-Seq). RECENT FINDINGS Lineage tracing of HSCs at the population level using multiple systems has suggested that HSCs make a major contribution to steady-state hematopoiesis. Although several genetic systems and novel methods for lineage tracing individual hematopoietic clones have been described, the technology for tracking these cellular barcodes (in particular mutations or insertion sites) is still in its infancy. Thus, lineage tracing of HSC clones in the adult bone marrow remains elusive. Static snapshots of scRNA-Seq of hematopoietic populations have captured the heterogeneity of transcriptional profiles of HSCs and progenitors, with some cells displaying a unilineage signature as well as others with bi or multipotent lineage profiles. Kinetic analysis using HSC-specific lineage tracing combined with scRNA-Seq confirmed this heterogeneity of progenitor populations and revealed a rapid and early emergence of megakaryocytic progeny, followed by erythroid and myeloid lineages, whereas lymphoid differentiation emerged last. SUMMARY New approaches to study HSCs both in vivo through lineage tracing and at a high-resolution molecular level through scRNA-Seq are providing key insight into HSC differentiation in the absence of transplantation. Recent studies using these approaches are discussed here. These studies pave the way for integration of in-vivo clonal analysis of HSC behavior over time with single-cell sequencing data, including but not limited to transcriptomic, proteomic, and epigenomic, to establish a comprehensive molecular and cellular map of hematopoiesis.
Mechanics of swimming and flying: Frontmatter

Preface 1. General considerations 2. The Stokesian realm 3. Swimming of a sheet 4. The biology of low-Reynolds-number locomotion 5. Resistive-force theory of flagellar propulsion 6. Analysis of the flagellum 7. Ciliary propulsion 8. The Eulerian realm: the inertial force 9. The Eulerian realm: the vortex force 10. The swimming of fish 11. Some aspects of the aerodynamics of birds and insects 12. Interactions References Index.
Effects of Various Forms of Unstable Load on Muscle Electromyography in the Stabilizing Musculature and Rating of Perceived Exertion in the Bench Press

Abstract Costello, K. Effects of various forms of unstable load on muscle electromyography in the stabilizing musculature and rating of perceived exertion in the bench press. J Strength Cond Res 36(4): 881–887, 2022—The purpose of the study was to determine whether unstable load training and the Swiss bar in the bench press can cause greater rating of perceived exertion (RPE) values and greater muscle activation in the stabilizing musculature and the same or greater in the primary movers with a decreased load. Division III college athletes (N = 24) performed 4 bench press interventions: stable bench press standard bar (SBp; 75% 1 repetition maximum), stable bench press Swiss bar (SwB; 65%), unstable bench press standard bar (UBp; 60%), and unstable bench press Bandbell bar (Bb; 60%). One-way repeated-measures analysis of variance was used to compare the average muscle activity values of pectoralis major (PM), triceps brachii (TB), anterior deltoid (AD), and biceps brachii (BB) and RPE values of each intervention. In the PM, mean muscle activity values were significantly (ps < 0.01) greater in the stable SwB and unstable Bb bar than the SBp. In the TB, mean muscle activity values were significantly (p < 0.001) greater in the stable SwB intervention than the SBp and UBp. Mean muscle activity values were significantly (p = 0.032) greater in the unstable Bb bar than the SBp intervention. In the AD, mean muscle activity values were significantly (p < 0.001) greater in the SBp than the stable SwB and significantly (p < 0.001) greater in the UBp and unstable Bb bar than the stable SwB. In the BB, mean muscle activity values were significantly (p < 0.001) greater in the UBp and unstable Bb than the SBp and significantly (p < 0.001) greater in the UBp and unstable Bb bar than the standard SwB. Mean muscle activity values were significantly (p < 0.001) greater in the unstable Bb bar than the UBp. The unstable Bb bar was perceived the most difficult when compared with other bars (ps < 0.01). The unstable interventions were viable options to replace the standard bench press as a method of upper-body resistance training.
Molecular and Biological Diversities of Cucumber green mottle mosaic virus from Cucurbitaceous Crops in Korea

Cucumber green mottle mosaic virus (CGMMV) is the first-known cucurbit-infecting tobamovirus. To analyse its biological and molecular diversities, 36 isolates of CGMMV were collected from watermelon (Citrullus vulgaris) and cucumber (Cucumis sativus) plants in Korea. The cDNAs of coat protein (CP) and partial movement protein genes of the isolates were synthesized by reverse transcription and polymerase chain reaction (RT-PCR) and subjected to single-strand conformation polymorphism (SSCP) analysis with 530 bp-synthesized RT-PCR products. CGMMV isolates were categorized into three subgroups by SSCP analysis, designated types I, II and III. All watermelon isolates of CGMMV belonged to types I and II, whereas cucumber isolates were subgrouped into types II and III. These three type isolates of CGMMV were divided by RT-PCR-restriction fragment length polymorphism (RFLP) using full-length cDNAs of three types of CGMMV. Biological properties of each subgroup-type of CGMMV isolates were determined by mechanical inoculation of common host plants of CGMMV. Among the virus isolates, isolate NW-1, belonging to type I, did not infect cucumber (cv. Baegbong), whereas all CGMMV isolates (types II and III) infected the same host species. In addition, all isolates of CGMMV types could infect Nicotiana debneyii, except that isolate KC1-2, subgrouped into type III, failed to infect. Nucleotide and predicted amino acid sequences of CP gene of CGMMV isolates were compared to those of reported CGMMVs and other cucurbit-infecting tobamoviruses. In phylogenetic tree analyses between CGMMV isolates and other cucurbit-infecting tobamoviruses, CGMMV was subgrouped as a cluster and no remarkable molecular diversity was found among the CGMMV isolates.
Oxidative stress enhances the expression of 2′,3′-cyclic phosphate-containing RNAs

ABSTRACT Eukaryotic cells equip robust systems to respond to stress conditions. In stressed mammalian cells, angiogenin endoribonuclease cleaves anticodon-loops of tRNAs to generate tRNA halves termed tRNA-derived stress-induced RNAs (tiRNAs), which promote stress granule formation and regulate translation. The 5′-tiRNAs (5′-tRNA halves) contain a 2′,3′-cyclic phosphate (cP) and thus belong to cP-containing RNAs (cP-RNAs). The cP-RNAs form a hidden layer of the transcriptome because standard RNA-seq cannot amplify and sequence them. In this study, we performed genome-wide analyses of short cP-RNA transcriptome in oxidative stress-exposed human cells. Using cP-RNA-seq that can specifically sequence cP-RNAs, we identified tiRNAs and numerous other cP-RNAs that are mainly derived from rRNAs and mRNAs. Although tiRNAs were produced from a wide variety of tRNA species, abundant species of tiRNAs were derived from a focal-specific subset of tRNAs. Regarding rRNA- and mRNA-derived cP-RNAs, determination of the processing sites of substrate RNAs revealed highly specific RNA cleavage events between pyrimidines and adenosine in generation of those cP-RNAs. Those cP-RNAs were derived from specific loci of substrate RNAs rather than from the overall region, implying that cP-RNAs are produced by regulated biogenesis pathways and not by random degradation events. We experimentally confirmed the identified sequences to be expressed as cP-RNAs in the cells, and their expressions were upregulated upon induction of oxidative stress. These analyses of the cP-RNA transcriptome unravel an abundant class of short ncRNAs that accumulate in cells under oxidative stress.
The Role of Hyperglycemia in Endometrial Cancer Pathogenesis

Endometrial cancer is one of the most common cancers in women worldwide and its incidence is increasing. Epidemiological evidence shows a strong association between endometrial cancer and obesity, and multiple mechanisms linking obesity and cancer progression have been described. However, it remains unclear which factors are the main drivers of endometrial cancer development. Hyperglycemia and type 2 diabetes mellitus are common co-morbidities of obesity, and there is evidence that hyperglycemia is a risk factor for endometrial cancer independent of obesity. This review aims to explore the association between hyperglycemia and endometrial cancer, and discuss the evidence supporting a role for increased glucose metabolism in endometrial cancer and how this phenotype may contribute to endometrial cancer growth and progression. Finally, the potential role of blood glucose lowering strategies, including drugs and bariatric surgery, for the treatment of this malignancy will be discussed.
New species and new records of Aphyllophorales (Basidiomycetes) from New Zealand

Abstract Two new species of Aphyllophorales are described from New Zealand: Perenniporia podocarpi and Plicaturopsis scarlatinus. Eight species are newly recorded from New Zealand, and an earlier record of one species is substantiated with specimens. The new combinations, Aurantioporus pulcherrimus (Rodway) comb. nov. and Phanerochaete rosea (P. Henn.) comb. nov., are proposed.
Effect of active cycle of breathing techniques in patients with chronic obstructive pulmonary disease: a systematic review of intervention.

INTRODUCTION Patients with chronic obstructive pulmonary disease (COPD) often suffer from expectoration. To address this problem, active cycle of breathing techniques (ACBT) can be applied. However, the effects of ACBT on COPD patients have shown mixed results. Therefore, we investigated the effectiveness of ACBT in patients with COPD by conducting a systematic review of the literature. EVIDENCE ACQUISITION Seven electronic databases (Pubmed; Web of science; Embase; CINAHL; China National Knowledge Infrastructure (CNKI); Chinese Biomedical Literature (CBM); Wanfang Database ) were carefully searched from August 17 to 19, 2019. EVIDENCE SYNTHESIS We initially retrieved 2,224 records and ultimately selected 8 articles. A total of 390 patients were included in the eight studies. The intervention program is a comparison of ACBT with non-ACBT. For COPD patients, active cycle of breathing was more effective in sputum production and cough efficiency. Compared with usual care, ACBT may improve lung function, blood gas analysis, and other parameters. CONCLUSIONS Our systematic review found that ACBT can effectively improve the sputum production and cough efficiency in patients with COPD. However, there was no definite conclusion on the effectiveness of ACBT on lung function, blood gas analysis and other aspects. More research and quantitative analyses are needed to confirm the effectiveness of ACBT on others aspects of COPD patient.
Water-Soluble Polysaccharides from Ephedra alata Stems: Structural Characterization, Functional Properties, and Antioxidant Activity

In this study, the physicochemical characterization, functional properties, and antioxidant activity of polysaccharides extracted from Ephedra alata (EAP) were investigated. EAP were extracted in water during 3 h with a liquid/solid ratio of 5 in a water bath at 90 °C. The structure of the extracted EAP was examined by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and gas chromatography-mass spectrometry (GC-MS). The functional properties and biochemical activities of EAP were determined. The chemical analysis revealed that the contents of carbohydrates, uronic acid, and proteins were 73.24% ± 1.24%, 6.82% ± 0.57%, and 6.56% ± 0.36%, respectively. The results showed that the extracted EAP essentially contain three functional groups: C=O, C-H, and O-H. SEM images showed that EAP present numerous high porosity particles. The monosaccharide composition revealed a polymer composed of glucose (43.1%), galactose (36.4%), mannose (14.9%), arabinose (3.7%), and gluconic acid (1.7%). EAP showed interesting functional properties (solubility, oil holding capacity, foaming and emulsion properties). Finally, the results revealed that EAP displayed excellent antihypertensive and antioxidant activities. Overall, EAP present a promising natural source of food additives, antioxidants, and antihypertensive agents.