Miracle-dz/UniFAR-FTUs huggingface dataset:
Socioeconomic status and outcome following acute myocardial infarction in elderly patients.

BACKGROUND Although the Medicare entitlement provides universal hospital care coverage for elderly Americans, disparities in care processes after acute myocardial infarction still exist. Whether these disparities account for increased mortality among elderly poor patients is not known. METHODS To determine the association between socioeconomic status and acute myocardial infarction treatment, procedure use, and 30-day and 1-year mortality, we analyzed data from 132 130 elderly Medicare beneficiaries hospitalized for acute myocardial infarction between January 1994 and February 1996. Patients were categorized into 10 groups of increasing income using the median income of the ZIP code of residence. RESULTS The highest-income beneficiaries received higher rates of evidence-based medical therapy and had lower adjusted 30-day and 1-year mortality rates compared with the middle-income beneficiaries (30-day relative risk, 0.89 [95% confidence interval, 0.85-0.94]; and 1-year relative risk, 0.92 [95% confidence interval, 0.88-0.97]). Conversely, the lowest-income beneficiaries received lower rates of evidence-based medical treatment and had higher adjusted 30-day and 1-year mortality rates relative to the middle-income beneficiaries (30-day relative risk, 1.09 [95% confidence interval, 1.04-1.13]; and 1-year relative risk, 1.05 [95% confidence interval, 1.00-1.10]). Coronary revascularization rates were similar among income groups. CONCLUSIONS Despite the Medicare entitlement, there remain significant socioeconomic disparities in medical treatment and mortality among elderly patients following acute myocardial infarction. Income was independently associated with short- and long-term mortality. More research is required to determine the mechanisms contributing to adverse outcomes among poor elderly patients and to determine whether expansion of Medicare coverage will alleviate these disparities.
Utilisation du dosage rapide de la protéine C réactive dans la prise en charge des fièvres aiguës de l’enfant en soins primaires : revue de la littérature

Contexte : La fievre de l’enfant est un motif de consultation frequent. La distinction entre une etiologie virale et bacterienne est parfois difficile cliniquement et peut etre amelioree par l’utilisation de la CRP capillaire. Objectif : L’objectif etait d’evaluer l’utilisation de la CRP capillaire en soins primaires dans la prise en charge de la fievre isolee de l’enfant. Methode : Une revue systematique de litterature a ete realisee dont les criteres de jugement principaux etaient l’utilisation de recours exterieurs, de prescription d’antibiotiques au cours de la consultation initiale et la morbidite. Resultats : 4 etudes francaises non randomisees, realisees entre 2002 et 2012, ont ete incluses. Lors de l’utilisation de la CRP capillaire une baisse des prescriptions d’examens biologiques etait observee : les demandes de NFS etaient diminuees de 17,22%, 96,2%, et 87,5%, les demandes de CRP etaient diminuees de 15%, 96,2%, et 90% et les demandes d’ECBU etaient diminuees de 21,1%, 48,1%, et 42,5% respectivement pour les etudes de Fraissinet-Astier 2004, Cohen 2008 et Boumoussi 2013. L’etude Cohen 2006 s’interessait uniquement aux demandes de NFS, elles etaient diminuees de 88,9%. Concernant les prescriptions de radiographies pulmonaires et d’admissions hospitalieres les resultats etaient heterogenes. Aucune etude ne s’interessait aux demandes de consultations specialisees, de controle ou a la morbidite. Les prescriptions d’antibiotiques etaient semblables dans les etudes. Conclusion : La CRP capillaire semble utile a la prise en charge de la fievre aigue de l’enfant, cependant de nouvelles etudes avec un niveau de preuve superieur sont necessaires.
System Guided View Integration for Object-Oriented Databases

Some of the shortcomings of current view integration methodologies, namely, a low emphasis on full-scale automated systems, a lack of algorithmic specifications of the integration activities, inattention to the design of databases with new properties such as databases for computer-aided design, and insufficient experience with data models with a rich set of type and abstraction mechanisms, are attacked simultaneously. The focus is on design databases for software engineering applications. The approach relies on a semantic model based on structural object-orientation with various features tailored to these applications. The expressiveness of the model is used to take the first steps toward algorithmic solutions, and it is demonstrated how corresponding tools could be embedded methodically within the view integration process and technically within a database design environment. The central ideal is to compute so-called assumption predicates that express suggested similarities between structures in two schemas to be integrated, and then have a human integrator confirm or reject them. The basic method is exemplified for the CERM data model that includes molecular aggregation, generalization, and versioning. >
A Small Molecule Inhibitor of Endoplasmic Reticulum Oxidation 1 (ERO1) with Selectively Reversible Thiol Reactivity*

Endoplasmic reticulum oxidation 1 (ERO1) is a conserved eukaryotic flavin adenine nucleotide-containing enzyme that promotes disulfide bond formation by accepting electrons from reduced protein disulfide isomerase (PDI) and passing them on to molecular oxygen. Although disulfide bond formation is an essential process, recent experiments suggest a surprisingly broad tolerance to genetic manipulations that attenuate the rate of disulfide bond formation and that a hyperoxidizing ER may place stressed cells at a disadvantage. In this study, we report on the development of a high throughput in vitro assay for mammalian ERO1α activity and its application to identify small molecule inhibitors. The inhibitor EN460 (IC50, 1.9 μm) interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation. Despite rapid and promiscuous reactivity with thiolates, EN460 exhibits selectivity for ERO1. This selectivity is explained by the rapid reversibility of the reaction of EN460 with unstructured thiols, in contrast to the formation of a stable bond with ERO1α followed by displacement of bound flavin adenine dinucleotide from the active site of the enzyme. Modest concentrations of EN460 and a functionally related inhibitor, QM295, promote signaling in the unfolded protein response and precondition cells against severe ER stress. Together, these observations point to the feasibility of targeting the enzymatic activity of ERO1α with small molecule inhibitors.
Differential antinociceptive effects induced by intrathecally-administered endomorphin-1 and endomorphin-2 in mice.

Two highly selective mu-opioid receptor (MOP-R) agonists, endomorphin-1 (EM-1) and endomorphin-2 (EM-2), have been identified and postulated to be endogenous ligands for MOP-R. Experiments were designed to determine the involvement of subtypes of MOP-R on the antinociceptive effects of EM-1 or EM-2 using the paw withdrawal test. The intrathecal (i.t.) injection of EM-1 and EM-2 produced dose-dependent antinociception in mice 1 min after the injection. Subcutaneous (s.c.) pretreatment with naloxonazine (NLZ), a selective MOP1-R antagonist, dose-dependently antagonized the antinociceptive effect of EMs. The antinociceptive effect of EM-2 was more sensitive to NLZ than that of EM-1. The selective heroin/morphine-6beta-glucuronide antagonist 3-methoxynaltrexone (3-MNT) blocked EM-2-induced antinociception, but not EM-1-induced antinociception. The dose-response curve of EM-2 was shifted threefold to the right by pretreatment with s.c. 3-MNT at a dosage of 0.25 mg/kg. EM-2-induced antinociception was attenuated by pretreatment with s.c. nor-binaltorphimine and naltrindole, whereas the effect of EM-1 was not affected. Moreover, the antinociceptive effect of EM-2 was attenuated by i.t. pretreatment with antisera against dynorphin A(1-17) or methionine-enkephalin. These results suggest that EM-2-induced antinociception may be mediated by the subtype of MOP-R, which is sensitive to NLZ and 3-MNT, and by subsequent release of dynorphin A(1-17) and methionine-enkephalin in the spinal cord.
Asymmetrical Cascade Multilevel Converters With Noninteger or Dynamically Changing DC Voltage Ratios: Concepts and Modulation Techniques

Asymmetrical cascade multilevel inverters offer a high number of voltage levels with a given switch count. For a given topology, the number of levels depends on the configuration of the dc voltage (ratios). This paper deals with the design and control of such converters with noninteger dc voltage ratio, which leads to unevenly distributed space vectors. It describes how to select the dc voltage ratio configurations that yield space vectors as evenly distributed as possible. It describes how to produce an effective PWM modulation that allows generating undistorted current even in the presence of (some) unevenly distributed space vectors.
Clinical and serologic study of four smallpox vaccines comparing variations of dose and route of administration. Primary percutaneous vaccination.

In an investigation of the antigenicity and reactogenicity of four smallpox vaccines, 786 children received primary percutaneous vaccination with vaccine in one of three concentrations, 10(6), 10(7), or10(8) pock-forming units/ml. Dose-response curves indicated that the three licensed vaccines (New York City Board of Health strains grown in calf lymph or chorioallantoic membrane, and the Lister vaccine) had similar potencies, but the CV-1 strain was about 10-fold less infectious. CV-1 also produced smaller skin lesions than the other three vaccines, and the incidence of fever in CV-1 vaccines who developed either "major reactions" or serum antibody was not significantly different from that in children in all vaccine groups with no evidence of "take. " Hemmagglutination-inhibiting antibody was consistently seen in individuals who received potent New York City and Lister vaccines, and neutralizing antibody was induced in 82%-85% of children in this group who had some evidence of take (production of hemagglutination-inhibiting antibody or or major reaction). Only 30% of CV-1 vaccines with takes produced neutralizing antibody. Minor complications occurred in all groups, but most often in children who received the New York City strains. "
Design and implementation of a new approach of LFMCW radar signal processing based on compressive sensing in azimuth direction

Application of Compressive Sensing (CS) in Linear Frequency Modulation Continuous Wave (LFMCW) radar had been investigated and proved by the authors in [8]. An approach, namely architecture 1, had been evaluated by the authors in [11] which dependent mainly on applying CS in range direction. But there is a limitation on the number of the detected targets in range. So, in the present paper, a new approach for applying CS in LFMCW radar signal processing, namely architecture 2, is introduced depends on apply CS in azimuth direction (range sweeps). The reduction in range sweeps is performed using a Pseudo Random (PN) sequence in Azimuth according to the required reduction ratio in range sweeps. The information of the received radar signal (target range and speed) are reconstructed by the use of Complex Approximate Message Passing (CAMP) reconstruction algorithm. Performance of the proposed LFMCW radar signal processors based on CS (architecture2) is evaluated and compared to that of both the traditional one based on Fast Fourier Transform (FFT)) and architecture 1 from points of view of detection performance through Receiver Operating Characteristics (ROC) curves, resolution performance and hardware complexity. The proposed approach (architecture 2) is designed and implemented using Field Programmable Gate Array (FPGA).
Influencia del estado emocional previo a la competición en el rendimiento deportivo

La prediccion y aumento del rendimiento deportivo es algo que todo entrenador busca desarrollar. Este trabajo pretende conocer cual es la influencia del estado emocional previo a la competicion en el rendimiento deportivo. Para ello, se han realizado diversas aproximaciones descriptivas y experimentales. En primer lugar, esta tesis se ha centrado en validar una nueva escala (POMS-VIC), basada en el modelo del profesor Lang (1968) y que intenta salvar las limitaciones encontradas en estudios previos en cuanto a la medida del perfil emocional del deportista desde una optica tridimensional de la emocion. En un segundo estudio se ha estudiado la validez predictiva de esta escala de manera experimental bajo condiciones de laboratorio para, posteriormente, hacerlo en situaciones reales de competicion. Por ultimo, se ha comprobado su validez respecto a pruebas y escalas similares, obteniendo en todos los apartados resultados altamente satisfactorios, lo que permite obtener una prueba con grandes beneficios en la aplicacion de la evaluacion y el entrenamiento en psicologia de la actividad fisica y el deporte. Tanto en terminos de aumento como de disminucion del rendimiento deportivo, los principales resultados encontrados reflejan el papel fundamental que juega el estado emocional previo y la manipulacion afectiva; prediciendolo a veces incluso mejor que pruebas fisicas y fisiologicas. Se ha encontrado que, a mayor puntuacion en la escala Valencia y Control, a mayor semejanza con el perfil emocional «Iceberg» (Morgan, 1980a) y con manipulaciones ligeramente negativas, se desarrolla un rendimiento superior. En este sentido, el ajuste de un modelo de regresion entre el rendimiento obtenido y las escalas consideradas (Valencia-Intensidad-Control) explica un 93 % de la varianza. Por ultimo, se cree necesaria ampliar la investigacion al respecto, asi como resulta necesario un mayor trabajo en el laboratorio con experimentos que incluyan elementos semejantes a los que aparecen en competicion, modificando estas condiciones e introduciendo la existencia de publico, la aparicion de recompensas economicas, o modificando las condiciones del contexto.
Structural analyses of EBER1 and EBER2 ribonucleoprotein particles present in Epstein-Barr virus-infected cells

The ribonucleoprotein (RNP) particles containing the Epstein-Barr virus-associated small RNAs EBER1 and EBER2 were analyzed to determine their RNA secondary structures and sites of RNA-protein interaction. The secondary structures were probed with nucleases and by chemical modification with single-strand-specific reagents, and the sites of modification or cleavage were mapped by primer extension. These data were used to develop secondary structures for the two RNAs, and likely sites of close RNA-protein contact were identified by comparing modification patterns for naked RNA and RNA in RNP particles. In addition, sites of interaction between each Epstein-Barr virus-encoded RNA (EBER) and the La antigen were identified by analyzing RNA fragments resistant to digestion by RNase A or T1 after immunoprecipitation by an anti-La serum sample from a lupus patient. Our results confirm earlier findings that the La protein binds to the 3' terminus of each molecule. Possible functions for the EBER RNPs are discussed.
Towards Deep Style Transfer: A Content-Aware Perspective

Modern research has demonstrated that many eye-catching images can be generated by style transfer via deep neural network. There is, however, a dearth of research on content-aware style transfer. In this paper, we generalize the neural algorithm for style transfer from two perspectives: where to transfer and what to transfer. To specify where to transfer, we propose a simple yet effective strategy, named masking out, to constrain the transfer layout. To illustrate what to transfer, we define a new style feature by high-order statistics to better characterize content coherency. Without resorting to additional local matching or MRF models, the proposed method embeds the desired content information, either semantic-aware or saliency-aware, into the original framework seamlessly. Experimental results show that our method is applicable to various types of style transfers and can be extended to image inpainting.
Robust decentralized power oscillation dampers design of DFIG wind turbines for stabilization of inter-area oscillation

A new decentralized power oscillation dampers (POD) design of doubly-fed induction generator (DFIG) wind turbines for damping of inter-area oscillation is presented in this paper. The practical 2nd-order lead/lag compensator with single input signal is used for the POD structure. The POD is equipped with the voltage controller of rotor side converter of DFIG. With the damping signal from POD, the reactive power output of DFIG can be modulated to damp out the oscillations. The parameters optimization of decentralized PODs is conducted over a wide range of tie-line power flow levels so that the damping performance of PODs can be enhanced. The improved firefly algorithm is used to achieve the optimal POD parameters automatically. Study results in a two-area four-machine interconnected system show that the stabilizing effect of proposed decentralized POD is higher than the conventional POD under severe faults, heavy power flows, and wind speeds.
Integrating Conflicting Chemotactic Signals

Leukocytes navigate through complex chemoattractant arrays, and in so doing, they must migrate from one chemoattractant source to another. By evaluating directional persistence and chemotaxis during neutrophil migration under agarose, we show that cells migrating away from a local chemoattractant, against a gradient, display true chemotaxis to distant agonists, often behaving as if the local gradient were without effect. We describe two interrelated properties of migrating cells that allow this to occur. First, migrating leukocytes can integrate competing chemoattractant signals, responding as if to the vector sum of the orienting signals present. Second, migrating cells display memory of their recent environment: cells' perception of the relative strength of orienting signals is influenced by their history, so that cells prioritize newly arising or newly encountered attractants. We propose that this cellular memory, by promoting sequential chemotaxis to one attractant after another, is in fact responsible for the integration of competitive orienting signals over time, and allows combinations of chemoattractants to guide leukocytes in a step-by-step fashion to their destinations within tissues.
Neurologic presentation of Wilson disease without Kayser-Fleischer rings

A 41-year-old woman presented with a 6-month history of gradually progressive postural instability and dysarthria associated with cerebellar and extrapyramidal signs. No Kayser-Fleischer (K-F) rings were observed on biomicroscopic examination of each cornea. The only evidence of hepatic dysfunction was a modest elevation of alanine-aminotransferase. The diagnosis of Wilson disease (WD) was based on low serum ceruloplasmin, abnormal serum copper and urinary copper excretion, and DNA marker segregation analysis. WD should be considered in the presence of characteristic neurologic and laboratory features, regardless of age at onset, evidence of hepatic dysfunction, or absence of K-F rings. NEUROLOGY 1996;46: 1040-1043
General Surface Modification Method for Nanospheres via Tannic Acid-Fe Layer-by-Layer Deposition: Preparation of a Magnetic Nanocatalyst

In this paper, a tannic acid-Fe layer-by-layer (TA-Fe LbL) modification process was developed to modify the highly curved surfaces of nanospheres. In contrast to the traditional TA-Fe one-step assembly method, TA-Fe coordination complexes were uniformly coated onto the surface of Fe3O4@SiO2 nanospheres by the TA-Fe LbL modification process with no TA-Fe aggregates forming on the nanospheres or in the reaction solution. By virtue of the reduction capability and effective immobilizing effect of TA, Ag nanoparticles (NPs) with small sizes (2–10 nm in diameter) and a narrow size distribution were formed in situ on the surface of the modified nanospheres. The resultant nanocomposites exhibited excellent catalytic performance and good stability for the reduction of 4-nitrophenol. This strategy can be extended to modify various highly curved surfaces to fabricate a variety of functional nanocomposites.
Association of Risk Factors and Drug Resistance Pattern in Tuberculosis Patients in North India

Context: India is one of the high tuberculosis (TB) burden countries in the world. Improper implementation in the guidelines for the management of TB and high rate of defaults on the part of the patients are most important risk factors for the development of multi-drug resistant TB. Aims: This study examines the drug resistance profile and the effect of demographic, clinical and behavioral risk factors on the prevalence of TB and multidrug resistance (MDR) in north India. Settings and Design: This was a prospective, observational study carried out from May 2012 to February 2014 in tertiary care hospital of Varanasi. Subjects and Methods: The study was performed on 721 pulmonary and extrapulmonary specimens of suspected TB patients based on history, was subjected for the Ziehl–Neelsen staining and culture on Lowenstein–Jensen (LJ) media. Statistical Analysis: The features of groups were compared by Chi-square (χ2) and odds ratio. Results: Out of 721 clinically suspected pulmonary and extrapulmonary TB patients, 222 (30.8%) patients were smear positive for acid-fast bacilli and 244 (38.3%) were positive for Mycobacterium species cultured on LJ medium. The prevalence of resistance to at least one anti-TB drug was 71.1% and MDR was 53.5%. Age, gender, HIV status, nature of TB, smoking, and alcohol consumption risk factors were significantly associated with TB prevalence; while prior history of TB infection, pervious household exposure, smoking, and alcohol consumption were significantly associated with MDR. Conclusion: This study showed a high prevalence of drug resistance TB in this region. It also provides evidence in our circumstance, of the role of prior history of TB infection, alcohol and smoking in increasing the risk of developing TB and MDR-TB. Therefore, it is necessary for the public health community to incorporate and strengthen alcohol and smoking nonparticipation interference in TB control program.
Behavioral comparison of Si and SiC power MOSFETs for high-frequency applications

As SiC MOSFETs have become more popular today, it is important to understand how the new devices are different from the conventional Si MOSFETs, and whether they can directly replace their Si counterparts in converters. This paper answers these questions through comprehensive comparisons of the two technologies in the device static characteristics, switching performances, temperature behaviors, and loss distributions in a high-frequency DC-DC converter. The paper shows that the SiC MOSFETs do exhibit different behaviors than Si in many ways, explains how they are co-related with the device characteristics, and proposes the design considerations when using these new devices in high-frequency converters.