Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of dietary carotenoids on plasma and plumage colour in the house finch: intra- and intersexual variation

1. Although carotenoid pigments cause much of the red, orange, yellow and violet coloration in feathers, the processes by which carotenoids are transported from the diet to those feathers are poorly understood. 2. Male house finches (Carpodacus mexicanus) display substantial variation in expression of carotenoid-based plumage coloration, an ornamental trait known to influence female choice. 3. To test the hypothesis that variation in carotenoid pigmentation of feathers is caused by processes that occur before the uptake of carotenoids by follicle cells during moult, we compared the hues of blood plasma and growing feathers in three populations (two in California and one in Mexico) of house finches that differed in median male plumage brightness. 4. In all three populations, there was a significant positive correlation between the hues of plasma and plumage in males, but there were no significant correlations between the hues of plasma and plumage in females
Diurnal Rhythmicity Programs of Microbiota and Transcriptional Oscillation of Circadian Regulator, NFIL3

Circadian rhythms are a very exquisite mechanism to influence on transcriptional levels and physiological activities of various molecules that affect cell metabolic pathways. Long-term alteration of circadian rhythms increases the risk of cardiovascular diseases, hypertension, hypertriglyceridemia, and metabolic syndrome. A drastic change in dietary patterns can affect synchronizing the circadian clock within the metabolic system. Therefore, the interaction between the host and the bacterial community colonizing the mammalian gastrointestinal tract has a great impact on the circadian clock in diurnal programs. Here, we propose that the microbiota regulates body composition through the transcriptional oscillation of circadian regulators. The transcriptional regulator, NFIL3 (also called E4BP4) is a good example. Compositional change of the commensal bacteria influences the rhythmic expression of NFIL3 in the epithelium, which subsequently controls obesity and insulin resistance. Therefore, control of circadian regulators would be a promising therapeutic target for metabolic diseases.
A numerical study on regular detonation structure and its evolution through the cell

This paper reports results on two dimensional numerical simulation of cellular detonation wave of H2/O2/Ar mixture with low initial pressure using detailed chemical reaction model and high order ENO scheme. A regular cellular structure develops from the one dimensional detonation wave after introduction of small random disturbances. The calculations are carried out using different grid sizes, and clear and well defined strong type structure and numerical detonation cells are obtained with high resolution calculations. Several aspects of the structure evolution through the cell are then discussed, such as shock configuration movement, pressure variation, ignition mechanisms and detonation velocity fluctuation.
High‐pressure metamorphic mineralogy of the Martian crust with implications for density and seismic profiles

Here, we calculate the mineralogy of the Martian lower crust and upper mantle as a function of pressure and temperature with depth using four bulk compositions (average crust, Gusev basalt, olivine‐phyric shergottite, and primitive average mantle). We then use this mineralogy to extract rock properties such as density and seismic velocities, describe their changes with varying conditions and geotherms, and make predictions for the crust–mantle boundary. Mineralogically, all compositions produce garnet, orthopyroxene, clinopyroxene in varying proportions at high pressures, with differences in minor minerals (spinel, ilmenite, rutile, and/or K‐feldspar). According to our calculations, the average crust and Gusev basalt compositions have the potential to yield higher densities than the average mantle composition, particularly for thicker crusts and/or colder geotherms. Therefore, recycling of the Martian crust into the mantle could occur through the process of crustal delamination, if not kinetically inhibited. However, our results show that, depending on crustal thickness, the crust may not be easily distinguishable from the mantle in seismic properties.
HIIT the Road Jack: An Exploratory Study on the Effects of an Acute Bout of Cardiovascular High-Intensity Interval Training on Piano Learning

Pairing high-intensity interval training (HIIT) with motor skill acquisition may improve learning of some implicit motor sequences (albeit with some variability), but it is unclear if HIIT enhances explicit learning of motor sequences. We asked whether a single bout of HIIT after non-musicians learned to play a piano melody promoted better retention of the melody than low-intensity interval training (LIIT). Further, we investigated whether HIIT facilitated transfer of learning to a new melody. We generated individualized exercise protocols by having participants (n = 25) with little musical training undergo a graded maximal exercise test (GXT) to determine their cardiorespiratory fitness (VO2peak) and maximum power output (Wmax). In a subsequent session, participants practiced a piano melody (skill acquisition) and were randomly assigned to a single bout of HIIT or LIIT. Retention of the piano melody was tested 1 hour, 1 day, and 1 week after skill acquisition. We also evaluated transfer to learning a new melody 1 week after acquisition. Pitch and rhythm accuracy were analyzed with linear mixed-effects modeling. HIIT did not enhance sequence-specific retention of pitch or rhythmic elements of the piano melody, but there was modest evidence that HIIT facilitated transfer to learning a new melody. We tentatively conclude that HIIT enhances explicit, task-general motor consolidation.
Non-human Primate Determinants of Natural Killer Cells in Tissues at Steady-State and During Simian Immunodeficiency Virus Infection

Natural killer (NK) cells play essential roles in immunity to viruses and tumors. Their function is genetically determined but also modulated by environmental factors. The distribution and functional regulation of these cells vary depending on the tissue. NK cell behavior in lymphoid tissues is so far understudied. Non-human primate (NHP) models are essential for the development of therapies and vaccines against human diseases, and access to NHP tissues allows insights into spatial regulations of NK cells. Here, we investigated tissue-specific parameters of NK cells from NHP species, i.e., cynomolgus macaque (Macaca fascicularis), African green monkey (Chlorocebus sabaeus), rhesus macaque (Macaca mulatta), and baboon (Papio anubis). By comprehensive multi-dimensional analysis of NK cells from secondary lymphoid organs, intestinal mucosa, liver, and blood, we identified tissue- and species-specific patterns of NK cell frequencies, phenotypes, and potential activity. Also, we defined the tissue-specific characteristics of NK cells during infection by the simian immunodeficiency virus. Altogether, our results provide a comprehensive anatomic analysis of NK cells in different tissues of primates at steady-state and during a viral infection.
Direct Oral Anticoagulants vs. Vitamin-K Antagonists in the Elderly With Atrial Fibrillation: A Systematic Review Comparing Benefits and Harms Between Observational Studies and Randomized Controlled Trials

Background: The publication of high-quality observational studies (OSs) has fueled reassessment of the treatment effects of direct oral anticoagulants (DOACs) in the elderly with atrial fibrillation (AF). Methods: The MEDLINE, EMBASE, and Cochrane Library databases were systematically searched (through July 1, 2019) for eligible OSs and randomized controlled trials (RCTs) that reported effectiveness outcomes [stroke or systemic embolism (SE)] or safety outcomes [intracranial hemorrhage (ICH), major bleeding, gastrointestinal bleeding (GIB), myocardial infarction (MI), and all-cause mortality] for DOACs and vitamin-K antagonists (VKAs) in elderly AF patients. A random-effects model was applied to calculate adjusted hazard ratios (HRs) for OSs and relative risks (RRs) for RCTs. Interaction analyses and the ratio of HR (RHR) were used to assess and compare OSs and RCTs. Results: A total of 32 studies involving 547,419 patients were included. No significant difference in treatment effect estimates was found between 27 OSs and 5 RCTs [Pinteraction > 0.05 for each and all 95% confidence interval (CI) of RHR crossed 1.0]. Compared with VKAs, DOACs significantly reduced risk for stroke/SE (OSs, HR: 0.87, 95% CI: 0.81–0.94; RCT, RR: 0.82, 95% CI: 0.67–0.96), and ICH (OSs: 0.47 [0.37–0.57]; RCTs: 0.47 [0.31–0.63]), without increasing risk for GIB (OSs: 1.21 [0.98–1.43]; RCTs: 1.34 [0.91–1.77]), and all-cause mortality (OSs: 1.01 [0.92–1.11]; RCTs: 0.94 [0.87–1.00]). Among OSs, DOACs significantly decreased risk for major bleeding (0.87 [0.77–0.98]) and MI (0.89 [0.79–0.99]). It was found that dabigatran, but not other DOACs, significantly increased risk for GIB (1.48 [1.23–1.72]). Conclusions: DOACs were demonstrated to be more effective and safer than VKAs in elderly AF patients, whereas dabigatran users had a 48% increase in risk for GIB.
Reflecting on the Potential and Limitations of Urban Agriculture as an Urban Greening Tool in South Africa

Urban green spaces have been researched extensively for their contribution toward livable, sustainable and resilient cities. Studies illustrate increasing awareness of the multi-functional roles such spaces can fulfill in addressing urbanization pressures and associated impacts such as increasing stress on global food systems, notably by accommodating practices of urban agriculture (UA). This paper investigates the potential for UA in South Africa as a citizen-led urban greening strategy, considering potential and limitations for the increased application of UA in spatial planning. The paper provides a review of core concepts and illustrates potential and certain limitations via UA cases studies in two leading South African provinces and a review of the national policy and legislative framework pertaining to UA. Findings highlight particular issues for consideration to augment the implementation of UA in South Africa, including opportunities to draw on existing citizen-led initiatives and increasing awareness of UA among communities, authorities, non-governmental organizations, and the private sector; the potential to utilize skilled and knowledgeable rural migrants; and possibilities to capitalize on a growing market for UA related opportunities to stimulate economic growth and employment creation whilst addressing food security concerns. Limitations highlighted in the paper, include many current UA initiatives not being self-sustaining and fully citizen-driven, requiring constant support and resources from multiple stakeholders; a cultural stigma attached to UA activities, hampering more uptake, especially among the youth; limited national support as no dedicated national policy on UA exists to direct the spatial planning community; and lastly, that South African spatial planners exhibit limited knowledge of UA and green infrastructure in general. The paper concludes with broad recommendations for the international planning community to advance the implementation of UA as a citizen-led urban greening strategy, drawing on the South African experience.
Soybean rust development and the quantitative relationship between rust severity and soybean yield

Phakospora pachyrhizi was inoculated on two soybean (Glycine max) genotypes at three different reproductive growth stages (GS) in four trials. Leaf rust was more severe on Taita Kaohsiung No. 5 (TK 5), a commercial cultivar, than on SRE-B15-A (B15 A), a genotype selected for tolerance to leaf rust. At GS R6, the percentage of leaf area infected ranged from 14 to 95% for TK 5 and from 0 to 34% for B15 A. Values for area under disease progress curve (AUDPC) were significantly greater for TK 5 than B15 A. Yields in fungicide-protected plots ranged from 2,312 to 3,546 kg/ha and were not significantly different between the genotypes (.)
Combined Factors for Predicting Cognitive Impairment in Elderly Population Aged 75 Years and Older: From a Behavioral Perspective

To unravel the combined effect of risk and protective factors that may contribute to preserve or impair cognitive status, this prospective cohort study systematically investigated a cluster of factors in elders aged 75 years and older from Guangxi Longitudinal Cohort (GLC) dataset. GLC has tracked 630 oldest-elders for two times within 2 years and will continue to follow two times in the next 4 years. At baseline geriatric assessment, sociodemographic information (e.g., education, Mandarin, marriage, and income), physical status [body mass index (BMI), chronic disease/medicine], lifestyle factors (smoking, alcohol, and exercise), and self-rated mental health (self-care, well-being, anxiety) were recorded by online interview. With 2 years’ follow-up, Mini-Mental State Examination (MMSE) and memory test were performed through person-to-person interview. The performance of MMSE was applied to represent the responder’s cognitive status which classified into cognitive impairment and normal group based on a cutoff point of 20. An age-related cognitive declining trend of 15 stratified factors was observed, though with a small effect size (R-square: 0.001–0.15). The odds of exposure or non-exposure on factors (memory, self-care, exercise, income, education, and literacy) had a significantly different effect on cognitive impairment through multivariate analysis after adjusting other confounding variables. Through stepwise multiple logistic regression analysis, the following 12 factors/index would be integrated to predict cognitive impairment: gender, physical health factors (BMI, chronic disease), socioeconomic and lifestyle factors (education, literacy, Mandarin, marriage, income, and exercise), and psychological health factors (memory, self-care cognition, and anxiety). Related clinical and nursing applications were also discussed.
PHF-Core Tau as the Potential Initiating Event for Tau Pathology in Alzheimer’s Disease

Worldwide, around 50 million people have dementia. Alzheimer’s disease (AD) is the most common type of dementia and one of the major causes of disability and dependency among the elderly worldwide. Clinically, AD is characterized by impaired memory accompanied by other deficiencies in the cognitive domain. Neuritic plaques (NPs) and neurofibrillary tangles (NFTs) are histopathological lesions that define brains with AD. NFTs consist of abundant intracellular paired helical filaments (PHFs) whose main constituent is tau protein. Tau undergoes posttranslational changes including hyperphosphorylation and truncation, both of which favor conformational changes in the protein. The sequential pathological processing of tau is illustrated with the following specific markers: pT231, TG3, AT8, AT100, and Alz50. Two proteolysis sites for tau have been described—truncation at glutamate 391 and at aspartate 421—and which can be demonstrated by reactivity with the antibodies 423 and TauC-3, respectively. In this review, we describe the molecular changes in tau protein as pre-NFTs progress to extracellular NFTs and during which the formation of a minimal nucleus of the filament, as the PHF core, occurs. We also analyzed the PHF core as the initiator of PHFs and tau phosphorylation as a protective neuronal mechanism against the assembly of the PHF core.
Current Understanding of Natural Antibodies and Exploring the Possibilities of Modulation Using Veterinary Models. A Review

Natural antibodies (NAb) are defined as germline encoded immunoglobulins found in individuals without (known) prior antigenic experience. NAb bind exogenous (e.g., bacterial) and self-components and have been found in every vertebrate species tested. NAb likely act as a first-line immune defense against infections. A large part of NAb, so called natural autoantibodies (NAAb) bind to and clear (self) neo-epitopes, apoptotic, and necrotic cells. Such self-binding antibodies cannot, however, be considered as pathogenic autoantibodies in the classical sense. IgM and IgG NAb and NAAb and their implications in health and disease are relatively well-described in humans and mice. NAb are present in veterinary (and wildlife) species, but their relation with diseases and disorders in veterinary species are much less known. Also, there is little known of IgA NAb. IgA is the most abundant immunoglobulin with essential pro-inflammatory and homeostatic properties urging for more research on the importance of IgA NAb. Since NAb in humans were indicated to fulfill important functions in health and disease, their role in health of veterinary species should be investigated more often. Furthermore, it is unknown whether levels of NAb-isotypes and/or idiotypes can and should be modulated. Veterinary species as models of choice fill in a niche between mice and (non-human) primates, and the study of NAb in veterinary species may provide valuable new insights that will likely improve health management. Below, examples of the involvement of NAb in several diseases in mostly humans are shown. Possibilities of intravenous immunoglobulin administration, targeted immunotherapy, immunization, diet, and genetic modulation are discussed, all of which could be well-studied using animal models. Arguments are given why veterinary immunology should obtain inspiration from human studies and why human immunology would benefit from veterinary models. Within the One Health concept, findings from veterinary (and wildlife) studies can be related to human studies and vice versa so that both fields will mutually benefit. This will lead to a better understanding of NAb: their origin, activation mechanisms, and their implications in health and disease, and will lead to novel health management strategies for both human and veterinary species.
An Effective Strategy for Defense & Medical Pictures Security by Singular Value Decomposition

- Medical and Defense pictures are viewed as significant and delicate information in the medicinal informatics frameworks. For exchanging secure pictures over an unreliable system, building up a safe encryption technique is vital. In this quick creating universe of the Internet, verifying pictures is a noteworthy security worry away and correspondence. Pictures are inclined to altering, spillage and assaults. The idea of share matrix S(k,n) for the creation of shares has been investigated. These types of shares give a strength to the security or encryption of the confidential information and images.In this article, paper illustrates the utilization of share generation idea for encryption of the digital pictures in the SVD domain. The singular value of the SVD component functions as a good choice to create the shares of the picture. To bring the further improvement in the robustness, we apply FrFT. The sequence of the FrFT (α1, α2) combined with the singular vectors (i.e., U and V ) parts of the initial/base image functions similar to keys. A variety of quantitative parameters such as for example speed, number of pixels change rate (NPCR), unified average changing intensity (UACI), entropy, correlation coefficient, key sensitivity and mean square error (MSE) have been completely researched to examine the overall performance of the suggested technique.
Review of the Neural Processes of Working Memory Training: Controlling the Impulse to Throw the Baby Out With the Bathwater

Background Smartphone technology has enabled the creation of many working memory training (WMT) Apps, with those peer-reviewed described in a recent review. WMT claims to improve working memory, attention deficits, hyperactivity and fluid intelligence, in line with plasticity brain changes. Critics argue that WMT is unable to achieve “far-transfer”—the attainment of benefits to cognition from one taught context to another dissimilar context—associated with improved quality of life. However, brain changes after a course of WMT in frontoparietal and striatal circuits—that often occur prior to behavioral changes—may be a better indicator of far-transfer efficacy, especially to improve impulse control commonly dysregulated in those with addictive disorders, yet not commonly examined in WMT studies. Method In contrast to previous reviews, the aim here is to focus on the findings of brain imaging WMT training studies across various imaging modalities that use various paradigms, published via PubMed, Scopus, Medline, and Google Scholar. Results 35 brain imaging studies utilized fMRI, structural imaging (MRI, DTI), functional connectivity, EEG, transcranial direct current stimulation (tDCS), cerebral perfusion, and neurogenetic analyses with tasks based on visuospatial and auditory working memory, dual and standard n-back. Discussion Evidence suggests that repeated WMT reduces brain activation in frontoparietal and striatal networks reflective of increased neural circuitry efficiency via myelination and functional connectivity changes. Neural effects of WMT may persist months after training has ended, lead to non-trained task transfer, be strengthened by auxiliary methods such as tDCS and be related to COMT polymorphisms. WMT could be utilized as an effective, non-invasive intervention for working memory deficits to treat impulse and affective control problems in people with addictive disorders.
Potential Role of Dissolved Oxygen and Manganese Concentration on the Development of Biofilms Causing Reduction in Hydraulic Capacity of a Gravity-Fed Irrigation System

Water from the Blyderiver dam in the Mpumalanga province, South Africa is used for gravity-fed irrigation. Biofilm development in the pipelines causes an increase in pipeline surface roughness, reduced hydraulic capacity, and water delivery below design capacity. The role of manganese (Mn) concentration on biofilm development is of interest, since the water is currently extracted at depth near the bottom of the reservoir (45–50 m when full) where high Mn levels were measured during four sampling events over 2 years. In the water body, dissolved oxygen (DO) and Mn concentrations showed a strong, inverse correlation, with rapid decrease in DO at increased depth, mirrored by an increase in total and soluble Mn. The depth of this inflection point correlated with the reservoir's water level. DO concentrations typically remained constant between 8 and 9 mg l−1 in the upper regions of the water column, followed by a rapid decline to lower than 2 mg l−1 at deeper zones. Similarly, Mn concentrations remained constant with increasing depth, ranging between 10 and 100 μg l−1, followed by a rapid increase once the depth is reached where DO levels started to decline, to 8,631 μg l−1 near the bottom. In the main, 1.5 m diameter pipeline, Mn concentrations decreased with distance; from 8,631 μg l−1 at the extraction point to 134 μg l−1 at 23 km downstream in the bulk aqueous phase, while in the biofilm biomass, Mn concentrations decreased from 30105.4 mg kg−1 at 4.5 km to 23501.9 mg kg−1 at 12.5 km, and 13727.7 mg kg−1 at 28.4 km downstream. This decrease in Mn concentration with distance suggests that biofilm accumulation has not yet reached a steady state. The aesthetic and operational problems caused by manganese in drinking water systems is well-documented, with biological removal gaining increasing interest as alternative to physical and chemical removal strategies. This study showed that the microbial processes that are being harnessed in drinking water treatment, i.e., Mn accumulation through biofilm formation supported by Mn cycling in sand filters, may have undesirable consequences in bulk water distribution systems by causing notable reduction in flow.