Miracle-dz/UniFAR-FTUs huggingface dataset:
PERFORMANCE ASSESSMENT AND GEOMETRIC CALIBRATION OF RESOURCESAT-2

Abstract. Resourcesat-2 (RS-2) has successfully completed five years of operations in its orbit. This satellite has multi-resolution and multi-spectral capabilities in a single platform. A continuous and autonomous co-registration, geo-location and radiometric calibration of image data from different sensors with widely varying view angles and resolution was one of the challenges of RS-2 data processing. On-orbit geometric performance of RS-2 sensors has been widely assessed and calibrated during the initial phase operations. Since then, as an ongoing activity, various geometric performance data are being generated periodically. This is performed with sites of dense ground control points (GCPs). These parameters are correlated to the direct geo-location accuracy of the RS-2 sensors and are monitored and validated to maintain the performance. This paper brings out the geometric accuracy assessment, calibration and validation done for about 500 datasets of RS-2. The objectives of this study are to ensure the best absolute and relative location accuracy of different cameras, location performance with payload steering and co-registration of multiple bands. This is done using a viewing geometry model, given ephemeris and attitude data, precise camera geometry and datum transformation. In the model, the forward and reverse transformations between the coordinate systems associated with the focal plane, payload, body, orbit and ground are rigorously and explicitly defined. System level tests using comparisons to ground check points have validated the operational geo-location accuracy performance and the stability of the calibration parameters.
Chronic nicotine treatment changes the axonal distribution of 68 kDa neurofilaments in the rat ventral tegmental area

Region‐specific decreases of neurofilament proteins (NF) were described in the ventral tegmental area (VTA) of rats treated chronically with morphine, cocaine or alcohol. In a previous study, we demonstrated that NF levels were also changed in the VTA after chronic treatment with nicotine. The aim of this study was to clarify the submicroscopic basis of decreased immunoreactivity for NF‐68, NF‐160 and NF‐200, as determined by using NR4, BF10 and RT97 antibodies, respectively. Microdensitometric analysis of brain sections showed that immunoreactivity for all NF was reduced in the VTA of animals exposed chronically to nicotine (0.4 mg/kg per day, 6 days of treatment), when compared to rats exposed to saline. Reduction in immunoreactivity was significant for NF‐68 (P < 0.05), NF‐160 (P < 0.01) and NF‐200 (P < 0.05), showing a relative reduction of 34%, 42% and 38%, respectively, when compared to saline‐treated rats. No difference was observed for any of the NF under study when immunoreactivity measurements in the substantia nigra were compared. Ultrastructural analysis was applied to evaluate changes in NF‐68, NF‐160 and NF‐200 immunoreactivity in regions of the VTA that contain dopaminergic neurons following chronic nicotine treatment. At the electron microscopic level, no degenerative changes were found in neurons or glial cells of the VTA. With ultrastructural immunohistochemistry, evaluation of the homogeneity parameter of NF distribution showed a loss of homogeneity for NF‐68 linked to the nicotine treatment. In areas in which NF organization appeared well preserved, analysis of the numerical density of NF revealed no significant difference for NF‐68 (897/µm2 vs. 990/µm2), NF‐160 (970/µm2 vs. 820/µm2) and NF‐200 (1107/µm2 vs. 905/µm2) in nicotine‐treated rats when compared to saline‐treated rats. These results confirm that nicotine shares the same properties with cocaine and morphine in reducing NF in the VTA, a key brain structure of the rewards system, and that chronic nicotine treatment changes the axonal distribution of 68 kDa neurofilaments in the rat VTA.
On Sample Size and Inference for Two‐Stage Adaptive Designs

Summary. Proschan and Hunsberger (1995, Biometrics51, 1315–1324) proposed a two‐stage adaptive design that maintains the Type I error rate. For practical applications, a two‐stage adaptive design is also required to achieve a desired statistical power while limiting the maximum overall sample size. In our proposal, a two‐stage adaptive design is comprised of a main stage and an extension stage, where the main stage has sufficient power to reject the null under the anticipated effect size and the extension stage allows increasing the sample size in case the true effect size is smaller than anticipated. For statistical inference, methods for obtaining the overall adjusted p‐value, point estimate and confidence intervals are developed. An exact two‐stage test procedure is also outlined for robust inference.
Validating Self-rated Health in Different Ethnic Groups

Background. Subjective accounts of health status are increasingly utilized in social surveys and medical research to assess functioning and well-being. Despite the fact that substantial research evidence suggests that self-rated health is meaningful and provides valid and reliable data, some authors have raised concerns that different social groups may interpret the notion of health in different ways, and hence complete health measures in systematically different ways. This study evaluates the validity of using self-rated health status to measure health status in different ethnic groups. Methods. Logistic regression models were used to examine the association of selfrated health with more objective measures of morbidity in different ethnic groups. Sample. Two sources of data were used-the Health Survey for England (HSE) 1991-96 combined file and the Fourth National Survey of Ethnic Minorities (Ethmins4). Measures of health. Hypertension, presence of cardiovascular disease or diabetes, limiting health and number of visits to a doctor. Self-rated health was measured on 5-point scale ranging from excellent to very poor. Results. Poorer self-rated health was associated with greater morbidity within each ethnic group. Furthermore, there was little evidence that the association of self-rated health with more objective measures of morbidity differed between ethnic groups. Conclusion. The evidence reported here suggests that the use of a single item measure of self-rated health to measure health status in different ethnic groups is valid. Further research might usefully explore the validity of using more comprehensive profile measures of health status in different ethnic groups.
The Glycoprotein of Vesicular Stomatitis Virus Is the Antigen That Gives Rise to and Reacts with Neutralizing Antibody

The glycoprotein, but no other virion protein, of vesicular stomatitis virus was solubilized by the nonionic detergent Triton X-100 in low ionic strength buffer. The solubilized viral glycoprotein induced the synthesis of antibody that formed a single precipitin line with the glycoprotein and that neutralized the infectivity of the virus. The neutralizing activity of the antibody was efficiently blocked by purified glycoprotein.
Feasibility and reliability of body composition measurements in adults with severe intellectual and sensory disabilities.

BACKGROUND Anthropometric measurements are widely used to reliably quantify body composition and to estimate risks of overweight in healthy subjects and in patients. However, information about the reliability of anthropometric measurements in subjects with severe intellectual and sensory disabilities is lacking. OBJECTIVE The purpose of this study was to determine the feasibility and the test-retest reliability of body composition measures in subjects with severe intellectual and sensory disabilities. METHOD The study population consisted of 45 subjects with severe intellectual and sensory disabilities. Body mass index, waist circumference, skin folds and tibia length were measured. Reliability was assessed by Wilcoxon signed rank test, limits of agreement (LOA) and intraclass correlation coefficients. The outcomes were compared with values provided by the World Health Organization. RESULTS There were no significant differences between test and retest (P < 0.05). For the skinfold measurements, however, the LOA was insufficient. Intraclass correlation coefficients for all variables, except skinfold measurements, were 0.90 or above. CONCLUSION Test-retest reliability and feasibility for all measurements are acceptable in subjects with severe intellectual and sensory disabilities. Skinfold measurements, however, could not be reliably performed in these subjects. Measuring tibia length and using the determined formula to calculate body height from tibia length is a reliable alternative for measuring body height. Although measuring the body height of subjects with severe disabilities was feasible, measuring tibia length was more feasible.
The relationship between hazardous alcohol use and violence among street‐involved youth

BACKGROUND AND OBJECTIVES Alcohol is a major contributor to premature disability and death among youth, often due to physical trauma, violence, and suicide. The purpose of this study was to longitudinally examine the association between hazardous alcohol use and experiences of violence among a cohort of street-involved youth. METHODS Data were derived from the At-Risk Youth Study (ARYS), a prospective cohort of street-involved youth who use illicit substances in Vancouver, Canada. The outcome of interest was hazardous alcohol use defined by the US National Institute on Alcohol Abuse and Alcoholism as >14 drinks/week or >5 drinks on one occasion for men, and >7 drinks/week or >4 drinks on one occasion for women. We used Generalized Estimating Equations (GEE) analyses to examine factors independently associated with hazardous alcohol use. RESULTS Between 2005 and 2014, 1,149 drug-using youth were recruited and 423 (36.8%) reported hazardous alcohol use in the previous 6 months at study baseline. In multivariable GEE analyses, intimate partner violence (Adjusted Odds Ratio [AOR] = 1.53, 95% Confidence Interval [95%CI] = 1.12-2.10), and non-partner physical assault (AOR = 1.39, 95%CI = 1.21-1.59) were independently associated with hazardous alcohol use after adjusting for multiple potential confounders. DISCUSSION AND CONCLUSIONS A considerable proportion of youth in this setting reported hazardous alcohol use, which was independently associated with experiencing recent intimate and non-partner violence. SCIENTIFIC SIGNIFICANCE Combined interventions for violence and hazardous alcohol use should be integrated into service provision programs for street-involved youth. (Am J Addict 2017;26:852-858).
Buprenorphine suppresses heroin use by heroin addicts.

Heroin-dependent men were given buprenorphine (a partial opiate agonist-antagonist) or a placebo under duoble-blind conditions on a clinical research ward where they could acquire heroin (21 to 40.5 milligrams per day, intravenously). Buprenorphine significantly (P less than .001) suppressed the self-administration of heroin over 10 days. Control subjects took between 93 and 100 percent of the available heroin. The effects of buprenorphine were dose-dependent; a dose of 8 milligrams per day reduced heroin use by 69 to 98 percent; a dose of 4 milligrams per day reduced heroin use by 45 percent. Termination of buprenorphie maintenance did not result in opiate withdrawal signs or symptoms. The subjects liked buprenorphine and indicated that it was preferable to methadone or naltrexone. Buprenorphine should be a safe and effective new pharmacotherapy for heroin dependence.
In vitro evaluation of physical vapor deposition coated beta titanium orthodontic archwires.

OBJECTIVE To determine in vitro the frictional properties, surface morphology, and load deflection rate with looped designs of two newly developed titanium aluminum nitride (TiAlN) and tungsten carbide/carbon (WC/C) physical vapor deposition (PVD) coated beta titanium orthodontic archwires coated with PVD. MATERIALS AND METHODS Frictional properties with Tidy's protocol, surface evaluation before and after friction testing with the help of scanning electron microscopy (ESEM), and load deflection rate with different orthodontic loops on Instron universal testing machine were evaluated. RESULTS The results clearly indicate reduced frictional properties for WC/C coated archwires when compared with uncoated and TiAlN coated archwires. There were no significant surface alterations upon ESEM evaluation of friction tested archwires. Low load deflection rate was exhibited by both coated archwires, the difference in load deflection rate between the coated and uncoated archwires was statistically significant. CONCLUSION WC/C coated wires can be recommended for even sliding mechanics due to reduced frictional properties, better surface characteristics, and low load deflection rate compared with TiAlN coated and uncoated archwires.
CD36 Protein Is Involved in Store-operated Calcium Flux, Phospholipase A2 Activation, and Production of Prostaglandin E2*

The scavenger receptor FAT/CD36 contributes to the inflammation associated with diabetes, atherosclerosis, thrombosis, and Alzheimer disease. Underlying mechanisms include CD36 promotion of oxidative stress and its signaling to stress kinases. Here we document an additional mechanism for the role of CD36 in inflammation. CD36 regulates membrane calcium influx in response to endoplasmic reticulum (ER) stress, release of arachidonic acid (AA) from cellular membranes by cytoplasmic phospholipase A2α (cPLA2α) and contributes to the generation of proinflammatory eicosanoids. CHO cells stably expressing human CD36 released severalfold more AA and prostaglandin E2 (PGE2), a major product of AA metabolism by cyclooxygenases, in response to thapsigargin-induced ER stress as compared with control cells. Calcium influx after ER calcium release resulted in phosphorylation of cPLA2 and its translocation to membranes in a CD36-dependent manner. Peritoneal macrophages from CD36−/− mice exhibited diminished calcium transients and reduced AA release after thapsigargin or UTP treatment with decreased ERK1/2 and cPLA2 phosphorylation. However, PGE2 production was unexpectedly enhanced in CD36−/− macrophages, which probably resulted from a large induction of cyclooxygenase 2 mRNA and protein. The data demonstrate participation of CD36 in membrane calcium influx in response to ER stress or purinergic receptor stimulation resulting in AA liberation for PGE2 formation. Collectively, these results identify a mechanism contributing to the pleiotropic proinflammatory effects of CD36 and suggest that its targeted inhibition may reduce the acute inflammatory response.
Aprotinin Treatment of Pseudomonal Corneal Infection

&NA; Pseudomonas aeruginosa produces proteolytic enzymes capable of causing severe corneal degradation. In this study we tested aprotinin, a broad‐spectrum protease inhibitor, on rabbit corneas infected with P. aeruginosa to determine whether any benefit could be derived. Corneas treated with aprotinin and tobramycin topically and subconjunctivally were not clinically better than corneas treated with tobramycin alone.
Monoamine precursors in the treatment of depression

The current biological theories of depression are united in postulating a role for brain monoamine deficiency in this group of disorders. The relative importance of the various amines, dopamine (DA), norepinephrine ( NE ), serotonin (5–HT ) and tryptamine, is still unsettled, and several versions of the monoamine deficit theory of depression have been put forward with emphasis on one or other of these compounds.5, 56, 94, 128
Severe Pediatric Blunt Trauma—Successful ROTEM-Guided Hemostatic Therapy With Fibrinogen Concentrate and No Administration of Fresh Frozen Plasma or Platelets

Use of allogeneic blood products to treat pediatric trauma may be challenged, particularly in relation to safety. We report successful treatment of a child with severe abdominal and pelvic injuries with preemptive fibrinogen supplementation followed by rotational thromboelastometry (ROTEM)-guided, goal-directed hemostatic therapy. Fibrinogen concentrate was administered (total dose: 2 g), while transfusion of fresh frozen plasma and platelet concentrate was avoided. Activated partial thromboplastin time was prolonged and Quick values were low but ROTEM clotting time values remained normal, therefore, no thrombin-generating drugs were considered necessary. This case shows the potential for hemostatic treatment with coagulation factor concentrates to be applied to pediatric trauma.
A 0.4 V Microwatt Power Consumption Current-Reused Up-Conversion Mixer

This letter proposes a novel up-conversion mixer with pseudo-differential and current-reused topology in 90 nm CMOS technology. The proposed source-pumped up-conversion mixer can operate at near weak inversion under a power consumption of 149 μW from a 0.4 V supply voltage while maintains acceptable circuit performance at millimeter-wave (MMW) frequencies. Measurement results show that the up-conversion mixer exhibits a -0.62 dB conversion gain (CG) and a -4 dBm OIP3. An achieved figure-of-merit (FoM) is 1.46.
Input and Output Application Programming Interface for Plaid Standard Library

Object oriented (OO) is the most accepted object modeling languages nowadays. Although OO languages are successful in modeling real world entities, nevertheless, there is little to no support for modeling state of object precisely in code. To overcome this problem, a new general purpose programming language is proposed that is built on two paradigms which are typestate-oriented and permission-based. One of the most vital factor for every language to be accepted and effective for users is having an enhanced standard library and clearly one of the most important parts is Input and Output (I/O) Application Programming Interface (API). One of a new programming language is Plaid language. Since the Plaid is at its early stage of development, I/O features provided by the Plaid standard library are very basic and limited. This paper presents I/O API that we have developed for the Plaid based on the features provided by Java I/O API. For the evaluation we used two metrics which are the number of features provided by I/O API, and the number of exceptions eliminated by using Plaid and typestate-oriented programming language.
Monolithic on-wafer rectangular waveguide and its transition to CPW lines

In this paper, we are introducing the design and fabrication of a monolithic wafer-level micro-machined rectangular waveguide for millimeter-wave applications. The 3D fabrication process used in this study allows for fabrication of both dielectric-filled and air-filled monolithic on-wafer waveguides. To perform the measurement and provide integration option to other types of planar structures, a novel wafer-level CPW to waveguide transition is designed, fabricated and tested. This brings the opportunity of simultaneous wafer-level fabrication of the rectangular waveguide, CPW lines and the transition between these lines. To fabricate this structure, a combination of thin film and thick film process is used. The proposed structure brings the opportunity of fabricating the entire millimeter-wave waveguide systems on wafer-level. Besides, air-filled waveguide allows for further expansion of the topic and integrating the waveguides with MEMS actuators to produce monolithic waveguide MEMS switches.
[Effects of androgen regulation system on bladder carcinogenesis in male mice].

PURPOSE In several previous reports, it has been suggested that the androgen system is related to bladder carcinogenesis. In this study, to understand the mechanism underlying this relationship, we administered a LH-RH agonist depot (Leuprolide depot), a pure-antiandrogen (flutamide) or a 5 alpha-reductase inhibitor (finasteride) to the mice in the promotion state of bladder carcinogenesis by N-butul-N-(4-hydroxybutyl) nitrosamine (BBN). MATERIALS AND METHODS 177 C3H/He male mice were divided into 7 groups. All mice were treated with 0.05% BBN for 10 weeks and were maintained over the subsequent 12 weeks with the following treatments. Group 1 was a control group; in group 2, castration was performed at the 11th week; in group 3, finasteride was administered starting the 11th week; in group 4, a LH-RH agonist depot was administered starting the 11th week; in group 5, flutamide was administered starting the 11th week; in group 6, both finasteride and a LH-RH agonist depot were administered simultaneously starting the 11th week; and in group 7, both flutamide and a LH-RH agonist depot were administered simultaneously starting the 11th week. RESULTS AND CONCLUSIONS (1) We confirmed that castration significantly suppressed bladder carcinogenesis. (2) Finasteride or flutamide administration as monotherapy had no effect on the results; however, the dosages of these drugs may have been too low, so we are planning a study with higher doses. (3) Conversely, the LH-RH agonist depot significantly promoted bladder carcinogenesis, we believe that the high levels of testosterone immediately after the administration were responsible for this promotion. (4) Simultaneous administration of flutamide suppressed this LH-RH induced promotion of carcinogenesis.
Evaluation of cell proliferation, epidermal growth factor receptor, and bcl‐2 immunoexpression as prognostic factors for patients with world health organization grade 2 oligodendroglioma

Prognostic factors in oligodendrogliomas are an area of controversy in neuropathology. Although grading and the study of some morphologic variables may be of value as prognostic parameters, the variability of postoperative disease free survival in patients with World Health Organization Grade 2 oligodendroglioma indicates that the biologic behavior of this entity remains unknown. The objective of the current study was to evaluate immunoexpression of the proliferation index (PI), epidermal growth factor receptor (EGFR), and bcl‐2 as prognostic factors in patients with Grade 2 oligodendroglioma.
Complex angular momentum approximation to hard-core scattering.

The complex angular momentum (CAM) approximation for nonrelativistic quantum scattering by a hard sphere - a union of the recently developed CAM uniform approximation with a semiclassical WKB-like approximation valid at large angles - is shown to be remarkably accurate over the complete range of scattering angles and down to size parameters (circumference to de Broglie wavelength ratios) of order unity. The best approximations previously derivable (Fock-type) cannot reach large scattering angles where semiclassical approximations are useful; even at angles where Fock-type approximations are valid, they are typically two or more orders of magnitude less accurate than CAM. The crucial new feature responsible for the high accuracy of the CAM approximation is the treatment of large-angle diffraction associated with (1) tunneling near the edge of the scatterer, and (2) anomalous reflection.