Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Olanzapine on QT Variability and Complexity Measures of Heart Rate in Patients With Schizophrenia

Previous studies have shown that untreated patients with acute schizophrenia present with reduced heart rate variability and complexity as well as increased QT variability. This autonomic dysregulation might contribute to increased cardiac morbidity and mortality in these patients. However, the additional effects of newer antipsychotics on autonomic dysfunction have not been investigated, applying these new cardiac parameters to gain information about the regulation at sinus node level as well as the susceptibility to arrhythmias. We have investigated 15 patients with acute schizophrenia before and after established olanzapine treatment and compared them with matched controls. New nonlinear parameters (approximate entropy, compression entropy, fractal dimension) of heart rate variability and also the QT-variability index were calculated. In accordance with previous results, we have observed reduced complexity of heart rate regulation in untreated patients. Furthermore, the QT-variability index was significantly increased in unmedicated patients, indicating increased repolarization lability. Reduction of the heart rate regulation complexity after olanzapine treatment was seen, as measured by compression entropy of heart rate. No change in QT variability was observed after treatment. This study shows that unmedicated patients with acute schizophrenia experience autonomic dysfunction. Olanzapine treatment seems to have very little additional impact in regard to the QT variability. However, the decrease in heart rate complexity after olanzapine treatment suggests decreased cardiac vagal function, which may increase the risk for cardiac mortality. Further studies are warranted to gain more insight into cardiac regulation in schizophrenia and the effect of novel antipsychotics.
RNA METABOLISM IN HELA CELLS AT REDUCED TEMPERATURE

Incubation of HeLa cells at 24°C results in the modification of the processing of pre-tRNA to tRNA. Both methylation and size reduction were shown to take place in vitro when purified pre-tRNA was subjected to processing in a cytoplasmic extract of HeLa cells The migration of pre-tRNA from the nucleus to the cytoplasm was not significantly altered at 24°C
Influence of recreational activity and muscle strength on ulnar bending stiffness in men.

Bone bending stiffness (modulus of elasticity [E] x moment of inertia [I]), a measure of bone strength, is related to its mineral content (BMC) and geometry and may be influenced by exercise. We evaluated the relationship of habitual recreational exercise and muscle strength to ulnar EI, width, and BMC in 51 healthy men, 28-61 yr of age. BMC and width were measured by single photon absorptiometry and EI by mechanical resistance tissue analysis. Maximum biceps strength was determined dynamically (1-RM) and grip strength isometrically. Subjects were classified as sedentary (S) (N = 13), moderately (M) (N = 18), or highly active (H) (N = 20) and exercised 0.2 +/- 0.2; 2.2 +/- 1.3; and 6.8 +/- 2.3 h.wk-1 (P < 0.001). H had greater biceps (P < 0.0005) and grip strength (P < 0.05), ulnar BMC (P < 0.05), and ulnar EI (P = 0.01) than M or S, who were similar. Amount of activity correlated with grip and biceps strength (r = 0.47 and 0.49; P < 0.001), but not with bone measurements, whereas muscle strength correlated with both EI and BMC (r = 0.40-0.52, P < 0.005). EI also correlated significantly with both BMC and ulnar width (P < 0.0001). Ulnar width and biceps strength were the only independent predictors of EI (r2 = 0.67, P < 0.0001). We conclude that levels of physical activity sufficient to increase arm strength influence ulnar bending stiffness.
Contralateral Periodic Limb Movement during Sleep after Ischemic Stroke in the Globus Pallidus

as repetitive and regular involuntary movement. It occurs primarily in the legs during sleep and usually consists of foot dorsiflexion and less often flexion at the knee or the hip. PLMS occurs 10-20% of general population and most prevalently in restless legs syndrome (RLS), which accounts for 80-90% of cases, but these movements can co-occur with a variety of sleep, medical, and neurological disorders and even with stroke. Previously reported cases of PLMS following ischemic stroke exhibited different clinical manifestations depending on the lesion site. These were associated with motor weakness with or without RLS. Here we report a case of contralateral PLMS without RLS following ischemic stroke in the right globus pallidus.
Hispanics and Patronage Preferences for Shopping From the Internet

The Hispanic market in the U.S. offers promising and lucrative online business opportunities. Spain's Terra Network, one of the biggest online content and access providers in the Latin countries, has teamed up with New Jersey based IDT to provide access to U.S. Hispanics (Folpe, 2000). Approximately, 1.3 million households and 2.3 million Hispanic small businesses are using the Web. Still, little published research exists documenting the shopping preferences for buying from the Web by this growing segment of the U.S. population. Applying the product classification and perceived risk literature from the previous published studies of Girard, Korgaonkar, Silverblatt (2002), the authors explore the Hispanic Web user's preferences for shopping from the Web. The study results and implications for managers are discussed.
A 3D occlusion tracking Model of the underwater fish targets

Multi-objective shining positioning and tracking technology is essential to behavior analysis in fish tracking. To achieve multi-target tracking, this paper proposes an occlusion-based method of fish tracking based on water quality testing platform. We systematically derive a theoretical model of real fish occlusion tracking, imaginary fish occlusion tracking, and real and imaginary fish concurrent occlusion tracing based on the following methods: the plan mirror imaging principle, and basic techniques of image processing such as target segmentation. Using this model, we aim to achieve 3D fish tracking without occlusion, fulfilling the requirements beforehand for fish target behavior analysis. The experimental results show the effectiveness of the proposed 3D fish target occlusion tracking Model.
COMPARTIMENTACIÓN INTERCELULAR DEL ACETATO EN NEURONAS Y ASTROCITOS DURANTE LA PRELACTANCIA

Durante el periodo perinatal el cerebro utiliza sustratos alternativos a la glucosa para mantener su desarrollo, pues en este momento sus niveles estan disminuidos. El acetato es metabolizado por las neuronas y los astrocitos durante la prelactancia. La utilizacion del acetato por estas celulas puede verse mejorada por las reacciones fijadoras de CO2, algunas de las cuales participan en el mantenimiento de los intermediarios del TCA, que son reducidos por la produccion y liberacion de aminoacidos, suministrando los recursos para la produccion de energia y sustratos que son compartimentados intercelularmente. Se estudio el efecto de la fijacion de CO2 en procesos metabolicos intercelulares donde esta involucrado el acetato. En incubaciones con neuronas y astrocitos de 7 y 14 dias de cultivo, utilizando acetato (5 mM) y [14C]-bicarbonato de sodio (10 μ Ci) (500-1000 dpm/nmol), se determino la incorporacion en metabolitos marcados en celulas y en sustratos estables liberados al medio. Adicionalmente, se realizaron experimentos similares utilizando inhibidores como el aminooxiacetato (AOA), dicloroacetato (DCA), α-ciano-4-hidroxicinnamato (α-CN), butilmalonato (BM) y bencenotricarboxilato (BT), cuantificando porcromatografia de capa delgada la concentracion en el medio de incubacion de alanina, aspartato, glutamato y glutamina. Los resultados indican que las neuronas tienen una menor capacidad para fijar carbonos en estructuras celulares, durante la prelactancia, pero utilizan mejor el acetato via acetil-CoA mitocondrial (AceCS2) para la produccion de energia y aminoacidos. En los astrocitos, estas reacciones favorecen la utilizacion del acetato via citrato liasa y Acetil-CoA citosolica (AceCS1) para la produccion de estructuras y sustratos utilizados por las neuronas, que para la produccion de aminoacidos.
Electronic and atomic structure of amorphous carbon.

The electronic structure of amorphous carbon and hydrogenated amorphous carbon (a-C:H) has been investigated through calculations on a number of model structures containing different configurations of ${\mathrm{sp}}^{2}$ and ${\mathrm{sp}}^{3}$ sites. We find that the most stable arrangement of ${\mathrm{sp}}^{2}$ sites is in compact clusters of fused sixfold rings, i.e., graphitic layers. The width of the optical gap is found to vary inversely with the ${\mathrm{sp}}^{2}$ cluster size, and the \ensuremath{\sim}0.5-eV optical gap of evaporated amorphous carbon is found to be consistent with a model of disordered graphitic layers of about 15 A\r{} in diameter, bounded by ${\mathrm{sp}}^{3}$ sites. It is argued that a-C forms such finite clusters in order to relieve strain. It is then shown that the 1.5--2.5-eV optical gap of a-C:H is unusually small and requires that both its valence and conduction band consist of \ensuremath{\pi} states on ${\mathrm{sp}}^{2}$ sites and that these sites must also be significantly clustered, such as in graphitic clusters containing four or more rings. In other words, the optical gap of both a-C and a-C:H depends on their degree of medium-range order, rather than just on their short-range order as is the case in most amorphous semiconductors. We have also studied the nature of states away from the gap in order to interpret the photoemission data and the carbon 1s core-level absorption spectra. The nature of defects and midgap states is discussed, and it is predicted that the defect density decreases with increasing band gap. Finally it is argued that the doping of a-C:H by group-III and -V elements proceeds via a substitution mechanism, as in a-Si:H, in spite of the coordination disorder present in a-C:H. Doping is also expected to be accompanied by an increase in gap states, as in a-Si:H.
A PIF‐dependent recombinogenic signal in the mitochondrial DNA of yeast

From their recombination properties, tandem rho‐ mutants of the mitochondrial genome of Saccharomyces cerevisiae were divided into two categories. In crosses between PIF‐independent rho‐ and rho+ strains, the recombination frequency is low and similar in PIF/pif and pif/pif diploids. In crosses between PIF‐dependent rho‐ and rho+ strains, the recombination frequency is stimulated 10‐50 times in PIF/pif diploids and is drastically decreased in pif/pif diploids. These results suggest that a recombinogenic signal is present in the mitochondrial (mt) DNA of PIF‐dependent rho‐ clones. This signal is not recognized in pif mutants. Sequence analysis of a series of small (<300 bp) overlapping tandem rho‐ genomes located in the ery region of the 21S rRNA gene led us to identify an essential element of this signal within a 41‐bp A+T sequence exhibiting over 26 bp a perfect dyad symmetry. However the recombinogenic signal is not sequence‐specific since the sequence described above does not characterize PIF‐dependent rho‐ clones located in the oli1 region. Our results rather suggest that the recombinogenic signal is related to the topology of rho‐ DNA. Denaturated sites in the double helix or cruciform structures elicited by local negative supercoiling might be preferred sites of the initiation of recombination.
Genetic dissection of a complex trait

A number of genetic and statistical tools were applied to various partitions of the simulated data to identify susceptibility loci, relevant environmental factors, and their interaction(s). The distribution of genotypes at D1G24 among affected children in the first population was found to differ significantly from Hardy‐Weinberg expectation. Two transmission/disequilibrium tests identified the preferential transmission of allele 1 as the source of the disequilibrium. Simple contingency table analysis revealed a positive association between exposure to environmental factor E1 and disease phenotype. Multipoint linkage analyses on various subsets of the data identified three “signal” regions (in addition to the aforementioned D1G24) localized at D1G9–10, D3G45, and D5G38. The even numbered chromosomes appeared to be devoid of susceptibility loci. Further analyses of subsamples of affected sib pairs, selected according to their disease phenotype and their exposure to E1, clarified some linkage relationships, particularly for D3G45, thereby suggesting the presence of a specific gene×environment interaction. Logistic analysis designed to clarify the relationship between disease phenotype and two risk factors (El exposure and the presence of allele 1 at D1G24) in the first population, revealed a significantly negative interaction which, upon learning the details of the generating model, we now attribute to the presence of heterogeneity.
A parallel processing method for Border Gateway Protocol UPDATE messages

With the expansion of the Internet, BGP (Border Gateway Protocol) protocol is faced with many challenges. However, inefficient linear method is still adopted to process routing UPDATE messages which seriously affects the performance of BGP protocol. In this paper, we propose a parallel processing method for BGP routing UPDATE messages with the pipeline and multithreading technologies. We also integrate garbage collection thread into the parallel processing method, which can further enhance the efficiency of routing UPDATE messages processing. We evaluate our parallel processing method on the prototype system of Quagga and make a comparison with the original BGPD module. Evaluation results show that our method is feasible and effective.
Fuzzy control for a MIMO nonlinear system with state constraints

In this paper, an adaptive fuzzy neural network control scheme is developed for a class of multiple-input and multiple-output (MIMO) nonlinear systems with uncertainties and state constraints. Fuzzy neural networks are used to approximate uncertainties in MIMO systems. Integral Lyapunov functions are introduced to address state constraints. By choosing an appropriate integral Lyapunov function, the control performances of the closed-loop system are completely guaranteed. Simulation results for MIMO systems with state constraints are carried out to prove the effectiveness of the designed control.
Relationship of migraine headaches to experience of chest pain and subsequent risk for myocardial infarction

This study examined the relationship between migraine, chest pain, and risk of myocardial infarction (MI) in a retrospective cohort of 79,588 enrollees in the northern California Kaiser Permanente Medical Care Program who underwent comprehensive, multiphasic preventive medicine examinations in 1971 to 1973.Migraine was ascertained by questionnaire as either symptom-based or self-report of physician diagnosis. Chest pain was ascertained by two questions regarding feelings of pain, pressure, or tightness in the chest that either hurt in the middle under the breastbone or forced the respondent to stop walking. Follow-up began at the time of each participant's medical examination and continued until the earliest occurrence of hospitalization for MI, death, termination of enrollment, or December 1987. There was a strong relationship between migraine and chest pain, but, in general, no significant association was found between migraine and risk of MI except among women with a family history of MI in whom a self-reported physician diagnosis of migraine was related to a greater than two-fold increase in risk. NEUROLOGY 1995;45: 2135-2142
Adults with ADHD

Abstract: Attention‐Deficit Hyperactivity Disorder (ADHD) is a common, genetically transmitted neurological disorder, with onset in childhood, probably mediated by decreased brain dopaminergic functioning. The first author was one of the earliest to describe the persistence of symptoms into adulthood. Prevalence and natural history data suggest that of the 3 to 10% of children diagnosed with ADHD, one‐ to two‐thirds (somewhere between 1 and 6% of the general population) continue to manifest appreciable ADHD symptoms into adult life. This paper describes how ADHD in adults can be readily diagnosed and treated, despite resembling or coexisting with other psychiatric disorders. The Wender Utah diagnostic criteria address adult characteristics of the disorder. Informant and patient interviews and rating scales are used to determine the psychiatric status of the patient as a child, make a retroactive diagnosis of childhood ADHD, and establish the current diagnosis of the adult. Stringent diagnosis is key to determining effective treatment. Dopamine agonist stimulant medications appear to be the most effective in treating ADHD. About 60% of patients receiving stimulant medication showed moderate‐to‐marked improvement, as compared with 10% of those receiving placebo. The core symptoms of hyperactivity, inattention, mood lability, temper, disorganization, stress sensitivity, and impulsivity have been shown to respond to treatment with stimulant medications. Non‐dopaminergic medications, such as the tricyclic antidepressants and SSRIs have generally not been useful in adults with ADHD in the absence of depression or dysthymia. Pemoline is no longer appoved for use in these patients, despite early favorable reports. Appropriate management of adult patients with ADHD is multimodal. Psychoeducation, counseling, supportive problem‐directed therapy, behavioral intervention, coaching, cognitive remediation, and couples and family therapy are useful adjuncts to medication management. Concurrent supportive psychosocial treatment or polypharmacy may be useful in treating the adult with comorbid ADHD.
Socioeconomic status: a disease modifier of chronic rhinosinusitis?

INTRODUCTION The Lund-MacKay score (LMS) correlates poorly with chronic rhinosinusitis (CRS) symptom severity. Patients with CRS also tend to report relatively lower levels of mental wellbeing. Our purpose was to determine if there is a correlation between socio-economic status (SES) and CRS severity as measured by the LMS, and if there is an association between depression symptoms and the severity of CRS using the LMS. METHODS A total of 127 patients diagnosed with CRS were prospectively recruited and assessed with a sinonasal assessment questionnaire (SNAQ-11), and the Patient Health Questionnaire (PHQ-9) for depression. Each patient`s education level, family income, and smoking behavior were determined. The sinus CT scan was scored using the LMS. The data were analyzed using ordinary least squares (OLS) regression techniques. RESULTS Having a highschool education or less was associated with higher SNAQ-11 scores while being a daily smoker was associated with higher SNAQ-11 scores. There was no significant relationship between educational attainment, financial income or daily smoking and sinus CT score. Including depression scores in the SNAQ-11, regression equations indicated a significant and positive relationship between depression severity and SNAQ-11 score. CRS with polyps was negatively associated with SNAQ-11 scores but, as expected, it was positively associated with a higher LMS. CONCLUSIONS Lower SES status is a negative modifying factor of subjective CRS severity but it has no impact on the LMS. Depression symptoms are associated with increased subjective CRS severity but they have no effect on the LMS. How SES and depression impact on a patient`s self-reported disease severity requires further study.
A fluorimetric investigation of the binding of drugs to lysozyme

R E F E R E N C E S Labrude, P., Vigneron, C. (1980b) Ibid. 32: 588-589 Pristoupil, T. I. , Kramlova. M. , Uirych, S. (1978) Cesk. Evelyn, K. A,, Malloy, H. 1. (1938) J. Biol. Cheni. 126: F ~ ~ ~ . 27: 31 1-313 655-662 Regner, P. (1979) Sci. Techn. Pharm. 8 : 257-271 Finney, J. L. (1977) Phil. Trans. R. Soc. Lond. B. 278: 3-32 Suggett, F. (1975) in: Franks, F. (ed.) Water. a comprehensive treatise. Plenum Press, New York. London Labrude, P. Vigneron. C. , Streiff, F. (1976a) J . Pharm. Teisseire, B. , Teisseire, L. , A. , Hcrignult. R, , Belg. 31: 191-198 Laurent. D. (1975) Bull. Physiopathol. Resp. I I : Labrude, P., Loppinet, V. , Vigneron, C. (1976b) Ann. 837-851 Pharm. Fr. 34: 143-149 Labrude, P., Vigneron, C. (1980a) J. Pharm. Pharmacol. 32: 305-307
Orbital polarization and the insulating gap in the transition-metal oxides.

It is shown that an orbital-polarization correction to a spin-polarized band-structure calculation leads to an insulating gap for CoO, in sharp contrast to a standard band calculation. Orbital-polarization instabilities, though, are not found for FeO and ${\mathrm{La}}_{2}$${\mathrm{CuO}}_{4}$.
Morphine-6-glucuronide is more mu-selective and potent in analgesic tests than morphine.

6-glucuronidation of morphine confers to this widely used analgesic increased potencies both in terms of receptor binding (selectivity) and of antinociceptive properties. In binding studies, 6-glucuronidation of morphine results in increased mu/kappa selectivity (comparable to DAGO). Na+ ions and Gpp(NH)p inhibit similarly the binding of morphine and M6G at the mu sites, suggesting that M6G is a mu agonist. The agonist nature of M6G was further confirmed by its antinociceptive properties: M6G (i.c.v.) was considerably more potent than morphine in the writhing (45 fold) and in the tail-flick (61 fold) tests. Furthermore, M6G induced a longer lasting analgesic effect than morphine. These data strongly suggest that M6G may significantly contribute to the pharmacological activity of morphine.
Abnormal Placental Invasion—a Novel Approach to Treatment: Case Report and Review

The incidence of abnormal placental invasion has increased 10-fold in the past 50 years, reflecting the increased number of cesarean sections performed. Management relies on accurate early diagnosis with appropriate perioperative multidisciplinary planning to anticipate and avoid massive obstetric hemorrhage at delivery. Women at risk should plan to deliver at an institution with appropriate expertise and resources for managing this condition. We report a case of placenta increta management comprising preoperative placement of a pelvic artery balloon catheter, prophylactic balloon occlusion after delivery of the fetus, and embolization-assisted resection of the invaded uterine wall. We review incidence, methods of prenatal diagnosis, risk factors, and management of abnormally invasive placenta. Target Audience: Obstetricians & Gynecologists, Family Physicians Learning Objectives: After completion of this educational activity, the participant should be better able to recall risk factors for abnormal placental invasion, explain the diagnostic choices for identifying abnormal placental invasion, and prepare a logical treatment plan for the woman with abnormal placental invasion.
An Improving For Ranking Ontologies Based on the Structure and Semantics

Ontology specifies the concepts of a domain and their semantic relationships. It is widely used for solving the information heterogeneity problems on the web because of their capability to provide explicit meaning to the information. Different ontologies are created by developer for a same domain. To solve the heterogeneity problem among the specific domain several matching strategies are designed such as linguistic matcher, semantic similarity, structural comparison. Similarities among ontologies are obtained based on the term, concept relationship and terminological relationship as synonyms, hyponyms and homonyms. SWRL (Semantic Web Rule Language) rule is developed for common repository knowledge base to detect the homonyms. A merging framework combines the matching strategies for indentifying the similarities and dissimilarities of source ontologies then the similar concept are automatically merged and dissimilarities are directly merged in to the global ontology that resolve the synonyms and homonyms conflict among the domain specific ontologies.