Miracle-dz/UniFAR-FTUs huggingface dataset:
Differences in coping across stages of recovery from an eating disorder.

OBJECTIVE This study examined the relation between coping skills and eating disorder recovery by comparing these skills across healthy controls, fully recovered, partially recovered, and active eating disorder cases. Full recovery was defined using physical, behavioral, and psychological components. METHOD Individuals formerly seen for an eating disorder at a Midwestern clinic were categorized as having an active eating disorder (n = 53), as partially recovered (n = 15), or as fully recovered (n = 20). The coping skills of these groups were compared to each other and to 67 healthy controls. RESULTS Healthy controls and fully recovered individuals utilized similarly high levels of task- and avoidance-oriented coping and similarly low levels of emotion-oriented coping. Partially recovered individuals looked more similar to those with an active eating disorder. DISCUSSION Results provide support for a comprehensive definition of eating disorder recovery, of which healthy coping may be an integral component, and for the re-evaluation of the notion of "maladaptive" coping.
Understanding and profitably managing customer loyalty

Purpose – The purpose of the paper is to draw together the salient issues surrounding customer loyalty and customer relationship management (CRM) into a single coherent discussion. Various schools of academic thought are examined. The paper concludes with practical implications for managers.Design/methodology/approach – The literature surrounding customer loyalty, customer satisfaction, effective CRM and managing loyalty in a profitable manner are all reviewed. The paper allows managers to consider a wide range of material in the context of their business.Findings – The need for businesses to retain customers is an important issue in today's global marketplace. To retain customers, a business must forge loyal and long‐term relationships with profitable customers. Reasons why customers leave a company are discussed, and preventative strategies are considered. Loyalty schemes are considered and their relative merits examined.Practical implications – A key implication of this paper is the need to focus atten.
A beyond-1 GHz AMBA high-speed bus for SoC DSP platforms

This paper presents an on-chip interconnection infrastructure based on ARM's AHB standard to obtain a bus working beyond one gigahertz. All major design blocks necessary to implement reliable interconnect infrastructures for DSP platforms are presented. This interconnect infrastructure is implemented as a hard IP module to get the maximum performance out of TSMC's 0.18 /spl mu/m CMOS technology. As a result, a bus operating at 1.4 GHz capable of transferring 2.8 giga data items per second was successfully designed.
Hpr1 Is Preferentially Required for Transcription of Either Long or G+C-Rich DNA Sequences in Saccharomyces cerevisiae

ABSTRACT Hpr1 forms, together with Tho2, Mft1, and Thp2, the THO complex, which controls transcription elongation and genome stability inSaccharomyces cerevisiae. Mutations in genes encoding the THO complex confer strong transcription-impairment and hyperrecombination phenotypes in the bacterial lacZgene. In this work we demonstrate that Hpr1 is a factor required for transcription of long as well as G+C-rich DNA sequences. Using different lacZ segments fused to the GAL1promoter, we show that the negative effect of lacZsequences on transcription depends on their distance from the promoter. In parallel, we show that transcription of either a longLYS2 fragment or the S. cerevisiae YAT1G+C-rich open reading frame fused to the GAL1 promoter is severely impaired in hpr1 mutants, whereas transcription of LAC4, the Kluyveromyces lactis ortholog of lacZ but with a lower G+C content, is only slightly affected. The hyperrecombination behavior of the DNA sequences studied is consistent with the transcriptional defects observed in hpr1 cells. These results indicate that both length and G+C content are important elements influencing transcription in vivo. We discuss their relevance for the understanding of the functional role of Hpr1 and, by extension, the THO complex.
The molecular biology of caliciviruses.

IP: 54.70. 40.11 On: Thu, 25 Oct 2018 09:25:47 Journal of General Virology (1997), 78, 291–301. Printed in Great Britain .
A study on the detection of asynchronous state of the synchronous generator

This paper includes new protection concepts and practices to avoid mechanical damages of three-phase transformer by asynchronous operation of synchronous generator. This failure is often caused just after synchronous generator was connected to the grid because of a malfunction of the controller or misconnections of the synchronous devices. The results of the studies on the analyzing the phenomenon of asynchronous operation experienced in Korea and rapidly detecting asynchronous state are described.
Rapamune (Sirolimus, Rapamycin): An Overview and Mechanism of Action

Summary Rapamycin (Sirolimus, Rapamune), a potent immunosuppressive agent, has been demonstrated to have remarkable activity in inhibiting allograft rejection in animal models of transplantation. It is currently in phase II clinical trials. Rapamycin belongs to the class of macrocyclic immunosuppressive drugs that are bioactive only when bound to immunophilins. Cyclosporin A and FK506, two other members of this class, selectively block the transcriptional activation of several cytokine genes, thereby inhibiting cytokine production. Although rapamycin and its structural analog FK506 bind to the same immunophilin (FKBP), rapamycin acts at a later stage in T-cell cycle progression by blocking cytokine-mediated signal transduction pathways. This inhibition is the consequence of modulation of activity of a target protein by the rapamycin: FKBP complex [sirolimus effector protein (SEP)]. Although the identification of SEP has recently been reported, its function in cell-cycle progression is not known. The biochemical events that rapamycin has been shown to inhibit are (a) activation of p70S6 kinase, (b) activation of cdk2/cyclin E complex, (c) phosphorylation of retinoblastoma protein, and (d) suppression of cdc2 and cyclin A transcription.
Regulation of GFAP expression in glial‐like cells of the rat pituitary intermediate lobe by lactation, salt‐loading, and adrenalectomy

Glial‐like cells in rat pituitary intermediate lobe were localized and characterized by immunohistochemistry with antisera against glial fibrillary acidic protein (GFAP) and S‐100. Individual GFAP immunoreactive (IR) cells possessed several processes that often branched into secondary and tertiary processes, terminating with end‐feet. The GFAP‐immunopositive cell population was distributed in specific rostrocaudal and dorsoventral patterns. The distribution and numbers of cells differed between male and female rats. Examination of altered physiological states, e.g., adrenalectomy, lactation, and salt‐loading, revealed state‐specific changes in the appearance and distribution of GFAP‐IR cells. Adrenalectomy and lactation increased GFAP‐IR glial‐like cell numbers, whereas salt‐loading decreased their numbers and the typical pattern of distribution. By contrast, S‐100–expressing cells were evenly distributed in male and female rats, and its expression was not affected by the experimental conditions. Double‐label immunocytochemistry indicated that GFAP‐IR cells are a subpopulation of S‐100‐IR cells. These results suggest that cells normally expressing only S‐100 may be induced to express GFAP under altered physiologic conditions. Copy 1995 Wiley‐Liss, Inc.
Extracting the Young's Modulus and Stress Gradient of Thin Films from the Pull-in Voltage of a Micro Curled Cantilever Beam

This paper presents a high-precision algorithm for extracting the Young's modulus and stress gradient of thin films from the pull-in voltage measurement of a micro curled cantilever beam made of thin film materials. The algorithm considers the important issues including the fringing fields, the electromechanical coupling, and the stress-induced initial curling of the micro structures. The deviation of the extracted Young's modulus and stress gradient from the reality are below 4%. The present algorithm is very applicable to the wafer-lever testing of MEMS devices since the driving and response signals are both electric, the present algorithm could be accomplished using existing semiconductor testing equipments through probing on the bonding pads of devices.
The Potential Market for GM Rice with Health Benefits in a Chinese High-Risk Region

Genetically modified rice with a high folate content, i.e., folate biofortified rice, was recently developed to tackle folate deficiency. A consumer segmentation study is conducted to explore its market potential in the Chinese Shanxi Province, where the burden of folate deficiency is among the world’s highest. Cluster analysis of 451 rice consumers identified three segments: enthusiasts (14.2%), cautious (41.2%), and opponents (44.6%). Enthusiasts obtain the highest score of GM food knowledge and attitudes and have the highest GM rice acceptance rate, followed by cautious and reluctant consumers. Regarding GM food information, enthusiasts use almost entirely audiovisual channels and rely more on the industry, while other segments depend more on informal channels and anti-GM sources. Trust levels in these channels/sources differ between enthusiasts (high), opponents (neutral), and cautious (low). Based on multinomial regression, a targeted communication approach is recommended with a focus on female, cautious consumers and rural, low-educated opponents.
An independent investigation into the deployment of the federal communications commissions' rural health care pilot program.

OBJECTIVE the goal of this study was to provide an independent and objective evaluation of the implementation of the Federal Communications Commission's Rural Health Care Pilot Program. MATERIALS AND METHODS thirty-nine of the programs that were provided funding through this program were interviewed and asked about their project deployment, network planning, and the involvement of their state in implementation. RESULTS RESULTS showed that programs recruited project team members from a variety of fields to fulfill different roles. Network partners were often chosen because they were stakeholders in the outcome of the project and because they had a past working relationship with the grant-receiving programs. In terms of deployment, many programs had made progress in filling out necessary paperwork and were tracking milestones, but had experienced changes since first receiving funding, such as losing participants. Additionally, many encountered challenges that inhibited deployment, such as coping with rule fluctuations. Many of the programs received support from their respective state governments in project development, often through matching funds, but few states were involved in the actual management of projects. CONCLUSIONS as rural healthcare facilities often lack the information technology infrastructure compared with many urban facilities, it is important to understand the implementation process for programs such as the Rural Health Care Pilot Program and to examine what contributes to progress, stagnation, or disintegration. Although the programs reported some success, almost all had encountered challenges that inhibited implementation. A follow-up study is planned to further investigate deployment and determine the implications of Federal Communications Commission funding.
Shaping Small and Medium-Sized Enterprises’ Business Environment

Abstract Modern enterprises appear to be more and more focused on their intangible assets, among which the intellectual capital plays an important role. One of its components – relational capital – is an essential value of an organization as it helps build long-lasting relations between the company and its stakeholders. This, in turn, leads to a business’ competitive advantage. With the help of a research conducted, this study attempts to assess the relations between small and medium-sized enterprises (SMEs) and their business environment institutions.
AN ASSESSMENT OF CUSTOMER SATISFACTION IN THE TELECOM SECTOR OF GHANA

Ghana's telecom sector has enjoyed a financial boost in the last couple of years, with deals across both fixed and mobile platforms bringing some of the biggest operators in the world to the West African state (Burkson, 2011). Whilst the opportunities to make money in the mobile sector in Ghana remain buoyant, the network operators are increasingly looking at other sources of revenue as they are compelled to cut call prices in order to stay competitive. Research has proven that there are a number of factors, which influence awareness creation, satisfaction, loyalty and sense of belongingness toward services provided by telecommunication companies (telcos).
Study of the Preferred Crystallographic Orientation of Polycrystalline Aluminum on Silicon Dioxide and Silicon

Magnetron Physical Vapor Deposition of Aluminum (Al) on single crystal Si (111) at 400 ° C and on oxide at the room temperature are studied by x-ray diffraction and the field-emission scanning electron microscopy. We focused our study on aluminum grain boundary and the grain size. Here the preferred orientation of aluminum film is studied by X-ray diffraction and the grain size is studied by SEM. The preferred orientation of the polycrystalline aluminum is (111) for both aluminum films on both oxide and Si substrate. The FWHM of Al x-ray diffraction indicates that the surface energy from both the oxide and silicon made a good Al (111) preferred orientation. SEM provides us the images of the grain size and their alignment for Al on oxide and Si. It was found that the aluminum crystallites are elongated and perpendicular to the substrate. The poly-crystallite grain size of aluminum is affected by the annealing temperature. The crystallite grain size is bigger at the elevated temperature than the room temperature.
DNA Topoisomerase III from the Hyperthermophilic Archaeon Sulfolobus solfataricus with Specific DNA Cleavage Activity

ABSTRACT We report the production, purification, and characterization of a type IA DNA topoisomerase, previously designated topoisomerase I, from the hyperthermophilic archaeon Sulfolobus solfataricus. The protein was capable of relaxing negatively supercoiled DNA at 75°C in the presence of Mg2+. Mutation of the putative active site Tyr318 to Phe318 led to the inactivation of the protein. The S. solfataricus enzyme cleaved oligonucleotides in a sequence-specific fashion. The cleavage occurred only in the presence of a divalent cation, preferably Mg2+. The cofactor requirement of the enzyme was partially satisfied by Cu2+, Co2+, Mn2+, Ca2+, or Ni2+. It appears that the enzyme is active with a broader spectrum of metal cofactors in DNA cleavage than in DNA relaxation (Mg2+ and Ca2+). The enzyme-catalyzed oligonucleotide cleavage required at least 7 bases upstream and 2 bases downstream of the cleavage site. Analysis of cleavage by the S. solfataricus enzyme on a set of oligonucleotides revealed a consensus cleavage sequence of the enzyme: 5′-G(A/T)CA(T)AG(T)G(A)X↓XX-3′. This sequence bears more resemblance to the preferred cleavage sites of topoisomerases III than to those of topoisomerases I. Based on these data and sequence analysis, we designate the enzyme S. solfataricus topoisomerase III.
Formation of biofilms under phage predation: considerations concerning a biofilm increase

Bacteriophages are emerging as strong candidates for combating bacterial biofilms. However, reports indicating that host populations can, in some cases, respond to phage predation by an increase in biofilm formation are of concern. This study investigates whether phage predation can enhance the formation of biofilm and if so, if this phenomenon is governed by the emergence of phage-resistance or by non-evolutionary mechanisms (eg spatial refuge). Single-species biofilms of three bacterial pathogens (Pseudomonas aeruginosa, Salmonella enterica serotype Typhimurium, and Staphylococcus aureus) were pretreated and post-treated with species-specific phages. Some of the phage treatments resulted in an increase in the levels of biofilm of their host. It is proposed that the phenotypic change brought about by acquiring phage resistance is the main reason for the increase in the level of biofilm of P. aeruginosa. For biofilms of S. aureus and S. enterica Typhimurium, although resistance was detected, increased formation of biofilm appeared to be a result of non-evolutionary mechanisms.
Differential effects of digitalis on chemoreflex responses in humans.

To investigate the effects of digitalis on chemoreflexes in humans, we measured muscle sympathetic nerve activity (microneurography), minute ventilation, oxygen saturation, end-tidal carbon dioxide, mean arterial pressure, heart rate, and central venous pressure during stimulation of peripheral chemoreceptors with hypoxia, during stimulation of central chemoreceptors with hypercapnia, and during a cold pressor test before and after digitalis and placebo in 10 healthy volunteers on two different days (randomized, double-blind, cross-over design). Digitalis did not affect baseline measurements significantly. Despite similar changes in oxygen saturation and end-tidal carbon dioxide during hypoxia and hypercapnia with both placebo and digitalis, digitalis significantly potentiated overall ventilatory responses to hypoxia (+67 +/- 12% before versus +98 +/- 3% after digitalis; mean +/- SEM; P < .01) but did not affect the response to hypercapnia. Sympathetic nerve activity increased by 25 +/- 9% during hypoxia before digitalis and 30 +/- 10% during hypoxia after digitalis (P = NS) and increased by 38 +/- 18% during hypercapnia before digitalis and 26 +/- 11% during hypercapnia after digitalis (P = NS). Digitalis did not significantly change responses to the cold pressor test. Placebo had no effect on ventilatory and sympathetic nerve activity responses. We conclude that digitalis selectively augments ventilatory responses to peripheral chemoreceptor stimulation by hypoxia.
Temporal-Spatial Distribution of Hepatocyte Nuclear Factor-3β in Developing Human Lung and Other Foregut Derivatives

SUMMARY We assessed the temporal-spatial distribution of hepatocyte nuclear factor-3β (HNF-3β) in developing human lung and other foregut derivatives. Tissue from 31 fetuses (10-40 weeks) and 24 infants with hyaline membrane disease (HMD) or bronchopulmonary dysplasia (BPD) (2 days to 7 months) was studied. HNF-3β was detected in nuclei of epithelial cells of trachea and of conducting and terminal airways at 10 weeks. Thereafter, epithelial nuclei were immunolabeled more widely in peripheral than proximal airways. HNF-3β was confined to bronchiolo-alveolar portals and Type II cells in nonfetal lung. In infants with BPD, HNF-3 β was expressed abundantly in regenerating epithelial cells at the periphery of lung lobules. HNF-3 β was also detected in fetal esophagus, pancreas, duodenum, stomach, and gallbladder, suggesting that it is a marker for progenitor cells in foregut derivatives. The pattern of expression of HNF-3 β in the lung was similar to that of thyroid transcription factor-1 (TTF-1) at all ages. The temporal-spatial patterns of HNF-3 β and TTF-1 in the developing and regenerating lung are consistent with their proposed role in epithelial cell differentiation, regeneration, and surfactant protein gene expression.
The Effect of Exercise Therapy on Physical Function, Biochemistry and Dialysis Adequacy in Haemodialysis Patients: A Systematic Review and Meta-Analysis

Background:Patients undergoing dialysis have high mortality rates and a unique risk factor profile. Some improvements elicited by exercise training have been shown in dialysis populations, here we aimed to further explore the bene-fits of exercise. As well as changes in physical fitness we quantified cardiac function, depression, serum biochemistry, dialysis adequacy and energy intake following exercise training in people with chronic kidney disease (CKD) undertaking dialysis. Methods:A systematic literature search was completed in December 2012 identifying randomized, controlled trials of exercise training studies in haemodialysis (HD) patients. A subsequent meta-analysis was conducted.Results: Twenty four studies were included, totalling 879 patients. Exercise training produced significant improvements in physical fitness: peak VO2 5.03 mlO2·kg-1·min-1 (95% CI 3.73, 6.33, p 0.0001), Knee extensor strength 2.99 kg (95% CI 0.46, 5.52, p = 0.02) and 6 minute walk distance 60.7 metres (95% CI 18.9, 103, p = 0.004). Significant increases in energy intake MD 238 Kcal·day-1 (95% CI 94, 383, p = 0.001), serum Interleukin-6 MD-0.58 pg·ml-1 (95% CI-1.01, -0.15, p = 0.008) and Creactive protein MD 0.92 mg/L-1 (95% CI 0.29, 1.56, p = 0.004), but not Albumin or BMI, were reported. Improved Beck Depression scores were reported MD-6.9 (95% CI-9.7,-4.1, p 0.00001). Dialysis adequacy was reduced MD-0.23 (95% CI -0.29, -0.17, p 0.00001), while serum potassium was higher MD 0.14 mmol·L-1 (95% CI 0.01, 0.27, p = 0.04). Moreover exercise training appeared safe, with no direct exercise-associated deaths in over 30,000 patient-hours. Conclusions: Our pooled analyses confirmed improvements in physical fitness following exercise training and suggested additional improvements in dialysis efficiency (kt/v), serum potassium, inflammation and depression in HD patients.
VENTURE CAPITALISTS' INVESTMENT CRITERIA: 40 YEARS OF RESEARCH

In this paper, we review the literature on venture capitalists’ (VCs’) investment criteria from its early beginnings (Wells, 1972; Poindexter, 1975) to current studies (Silva, 2004; Khanin, 2006). We identify the most important decision criteria of investment in new ventures discussed in the literature, such as top management team, market, product, risk, deal and competition. In addition, we focus on the ongoing debate that can be traced in the literature as to whether management characteristics or product/market attributes play the most prominent role in impacting VCs’ decision to invest. We show that while VCs themselves typically believe that management capabilities matter more than any other factor, in-depth studies of VC decision making show that other characteristics, such as market growth rate and entrenched competition, may play a more important role. Furthermore, VCs often couple the criterion of management capabilities with that of the level of protection from competition. EXECUTIVE SUMMARY