Miracle-dz/UniFAR-FTUs huggingface dataset:
Opportunity or Loss? Health Impacts of Estate Renewal and the Relocation of Public Housing Residents

Abstract Estate renewal programs can have positive and negative impacts on the health and wellbeing of public housing residents. We aimed to investigate the potential health impacts of relocating residents as part of the redevelopment of a public housing estate in South Western Sydney, New South Wales. In-depth interviews were undertaken with public housing residents as well as with informants from local health and housing authorities. We found that a range of current and potential health impacts were linked to individual residents’ responses to the processes of estate redevelopment and relocation, housing and neighbourhood quality, residents’ social networks and access to social and health care services. Improved housing quality and maintenance, a personalised approach to relocation and equitable access to services were identified to contribute to positive health outcomes.
Regional sub-block matrices based multiple regularization and biomedical image reconstruction

A regional information based multiple regularization is studied for solving biological inverse problem. Inverse problems are usually optimized and solved by Newtons method and its variants. Optimization based on calculus is extremely localized. The regional gradient in calculus is more important for local physiological changes. A sub-block based multiple regularization is proposed in Gauss-Newtons method for biological diffuse optical tomograph (DOT). A study of single step regularization (STR) method and proposed subblock based multiple regularization method has been carried out. The reconstructed image analysis shows a significant improvement in the proposed method.
Exploration of anxiety sensitivity and distress tolerance as vulnerability factors for hoarding behaviors

Background: The phenomenon of compulsive hoarding, characterized by the acquisition of and failure to discard a large number of possessions, is increasingly recognized as a significant public health burden. Despite the magnitude of the impairment associated with this condition, empirical research is still in the nascent stages and many facets of the phenomenology, underlying vulnerability and risk factors for hoarding, are as of yet unknown. Method: The overall aim of the current investigation was to examine the association between hoarding behaviors and two potential vulnerability factors—anxiety sensitivity (AS) and distress tolerance (DT). In addition, we investigated the robustness of these associations as well as the interaction between the two hypothesized risk factors. Three studies (total N=745) involving independent nonclinical samples assessed hoarding, AS, DT, and relevant covariates using a range of measures. Resutlts: Findings revealed that AS and hoarding are significantly and robustly associated with one another beyond general depressive, anxiety, and nonhoarding obsessive–compulsive symptoms. Hoarding was also found to be associated with low DT. Consistent with prediction, AS and DT interacted such that DT may play a less important role among individuals with low AS. By contrast, low DT appears to increase vulnerability to hoarding symptoms among individuals high in AS. Results are discussed with regard to future research and treatment implications. Depression and Anxiety, 2009. Published 2009 Wiley‐Liss, Inc.
Interactions of Carbenicillin and Ticarcillin with Gentamicin

The in vitro inactivation of gentamicin by carbenicillin and a new semisynthetic penicillin, ticarcillin (BRL 2288), has been demonstrated. Gentamicin half-lives have been studied in eight patients with end-stage renal failure, and a 25 to 74% reduction in half-life has resulted from the concomitant administration of therapeutic doses of carbenicillin and ticarcillin.
Corporate Scam, Indictment and Reform: Louis Berger’s Values-based Approach to Reform

Abstract Corporate improbity and greed invariably impact a multitude of stakeholders both within the rogue corporation and beyond. Codes of conduct when breached violate the principles of morality and cause a lot of dismay to those impacted. A novice student of corporate governance might struggle to articulate the boundaries of morality. In situations where there is a conflict between corporate morals and corporate profits, what should take precedence – values or benefits? Louis Berger is a US based international consulting behemoth that provides infrastructure and economic development services across 80 countries globally. Embroiled in a whistle blower’s litigation and subsequent investigation by the Department of Justice it was caught defrauding the US taxpayers for well over a decade between 1997 and 2007. The company is a good example of how a global corporation enmeshed in indictments of wilful fraud by its former CEO and reckless violation of penal statutes by its senior employees is trying to reinvent itself to become a model corporate citizen. Its success or failure in becoming so will largely depend on the robustness of its corporate governance mechanisms and its willingness to leave behind its historic blunders.
Blood-brain barrier water permeability and brain osmolyte content during edema development.

OBJECTIVE To determine mechanisms that limit changes in brain water content during acute edema development. METHODS A controlled, laboratory investigation of the physiologic and biochemical correlates of osmotic edema was performed in rats. Hypoosmotic hyponatremia was induced by intraperitoneal injection of distilled water. Serum osmolality and electrolytes and regional blood-brain barrier water permeability. Surface area (P.S) product, osmolyte contents, and capillary size were determined during 120 minutes of hypoosmotic brain edema development. Cerebral water content predicted from these data using a mathematical model of brain water movements was compared with measured changes in brain water content. RESULTS Fifteen minutes after distilled water injection, mean +/- SEM blood serum osmolality and sodium concentration decreased from 291 +/- 3 mOsm and 131 +/- 13 mmol/L to 267 +/- 3 mOsm and 102 +/- 9 mmol/L, respectively. Specific gravity of cerebral gray matter, cerebral white matter, and basal ganglia decreased throughout the hypoosmotic exposure period and, for gray and white matter, correlated with blood serum osmolality and sodium plus potassium content. Glutamate, but not glutamine, glycine, or taurine, decreased 120 minutes after water injection. The regional water P.S product decreased by 40% to 60% within 60 minutes of the water injection, while capillary diameters in gray and white matter were unchanged. Brain water movements calculated from the mathematical model correctly predicted actual brain water content only if the hydraulic conductivity of the blood-brain barrier was allowed to vary in proportion to the measured P.S product and the measured loss of brain osmolytes was incorporated into the formulation. CONCLUSIONS During the first hours of hypoosmotic hyponatremia, changes in brain volume are limited by increased resistance to osmotic flux of water into the brain and reduction in the brain content of inorganic and, to a smaller degree, organic osmolytes.
Cognitive rehabilitation therapy after acquired brain injury in Argentina: Psychosocial outcomes in connection with the time elapsed before treatment initiation

Abstract Primary objective: To examine the effect of cognitive rehabilitation therapy (CRT) on psychosocial outcomes in Argentinean patients with acquired brain injury (ABI), in connection with the time elapsed between injury and treatment initiation. Research design: Self-reported data from patients in a naturalistic setting was collected before and after CRT. Methods and procedure: An outpatient sample of 75 Spanish-speaking patients with cognitive disturbances secondary to ABI (49 male/26 female, age: 50.2 ± 20.1 years; education 14.3 ± 3.2 years) completed a set of scales on their daily living activities, memory self-perception, quality-of-life and mood. Single and multi-group analyses were conducted, considering pre- and post- responses and the time elapsed between injury and treatment initiation. The influence of socio-demographic moderators was controlled during comparisons. Main results: Results suggest an improvement in several psychosocial indicators after treatment. Additionally, correlations and group comparisons showed greater improvement in subjective memory and quality-of-life self-reports in patients who began treatment earlier than those who began treatment after a longer time period. Conclusions: Overall, results suggest that CRT is associated with positive results in different areas of the psychosocial domain and that post-injury time can mediate this effect.
Intrapatient sequence variation of the gag gene of human immunodeficiency virus type 1 plasma virions

Because certain regions of the gag gene, such as p24, are highly conserved among human immunodeficiency virus (HIV) isolates, many therapeutic strategies have been directed at gag gene targets. Although intrapatient variation of segments of gag have been determined, little is known about the variability of the full-length gag gene for HIV isolated from a single individual. To evaluate intrapatient full-length gag variability, we derived the nucleotide sequences of at least 10 cDNA gag clones of virion RNA isolated from plasma for each of four asymptomatic HIV type 1-infected patients with relatively high CD4+ T-cell counts (300 to 450 cells per mm3). Mean values of intrapatient gag nucleotide variation obtained by pairwise comparisons ranged from 0.55 to 2.86%. For three subjects, this value was equivalent to that reported for intrapatient full-length env variation. The greatest range of intrapatient mean nucleotide variation for individual protein-coding regions was observed for p7. We did not detect any G-to-A hypermutation, as A-to-G and G-to-A transitions occurred at similar frequencies, accounting for 29 and 25%, respectively, of the changes. Mean variation values and phylogenetic analysis suggested that the extent of nucleotide variation correlated with the length of viral infection. Furthermore, no distinct subpopulations of quasispecies were detectable within an individual. The predicted amino acid sequences indicated that there were no regions within a gag protein that were comprised of clustered changes.
Influence of dexmedetomidine and clonidine on human liver microsomal alfentanil metabolism.

Perioperative administration of the alpha 2 agonist clonidine has been shown to increase plasma alfentanil concentrations; however, the mechanism for this pharmacokinetic drug interaction is unknown. Because alfentanil undergoes extensive hepatic biotransformation, clonidine inhibition of alfentanil metabolism may alter alfentanil disposition. The first purpose of this investigation was to test the hypothesis that clonidine impairs human liver alfentanil metabolism. The new highly selective alpha 2 agonist dexmedetomidine (D-medetomidine) is a substituted imidazole and thus may inhibit hepatic drug biotransformation. The second purpose of this study, therefore, was to assess the effect of D-medetomidine and its levo (L) isomer on alfentanil biotransformation. Human liver microsomal alfentanil metabolism was assessed in vitro using a gas chromatography--mass spectrometry assay. Clonidine, at concentrations as great as 10 microM (far exceeding therapeutic levels), had no significant effect on alfentanil oxidation. In contrast, D-medetomidine and its optical isomer L-medetomidine were potent inhibitors of human liver microsomal alfentanil metabolism. The concentration producing 50% inhibition (IC50) of alfentanil (10 microM) oxidation was 0.7-1.0 and 2.8-4.0 microM for D-medetomidine and L-medetomidine, respectively. Preincubation of D-medetomidine with microsomes did not enhance the inhibition of alfentanil metabolism. These results suggest that the increased alfentanil plasma concentrations and potentiation of alfentanil anesthesia associated with clonidine do not result from clonidine inhibition of alfentanil metabolism. D-medetomidine impairment of alfentanil metabolism, however,if present at therapeutic concentrations, may influence alfentanil disposition. (ABSTRACT TRUNCATED AT 250 WORDS)
Identifying circRNA-associated-ceRNA networks in the hippocampus of Aβ1-42-induced Alzheimer's disease-like rats using microarray analysis

Alzheimer’s disease (AD) is the most common form of dementia worldwide. Accumulating evidence indicates that non-coding RNAs are strongly implicated in AD-associated pathophysiology. However, the role of these ncRNAs remains largely unknown. In the present study, we used microarray analysis technology to characterize the expression patterns of circular RNAs (circRNAs), microRNAs (miRNAs), and mRNAs in hippocampal tissue from Aβ1-42-induced AD model rats, to integrate interaction data and thus provide novel insights into the mechanisms underlying AD. A total of 555 circRNAs, 183 miRNAs and 319 mRNAs were identified to be significantly dysregulated (fold-change ≥ 2.0 and p-value < 0.05) in the hippocampus of AD rats. Quantitative real-time polymerase chain reaction (qRT-PCR) was then used to validate the expression of randomly-selected circRNAs, miRNAs and mRNAs. Next, GO and KEGG pathway analyses were performed to further investigate ncRNAs biological functions and potential mechanisms. In addition, we constructed circRNA-miRNA and competitive endogenous RNA (ceRNA) regulatory networks to determine functional interactions between ncRNAs and mRNAs. Our results suggest the involvement of different ncRNA expression patterns in the pathogenesis of AD. Our findings provide a novel perspective for further research into AD pathogenesis and might facilitate the development of novel therapeutics targeting ncRNAs.
Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver

To study the role of glucokinase (CK) in the control of glucose metabolism in the liver, transgenic mice were generated in which GK was overexpressed under control of the P‐enolpyru‐vate carboxykinase gene promoter. Whereas the expression of the GK gene in starved control mice was blocked, this promoter was able to direct the expression of the enzyme to the liver of starved transgenic mice. Furthermore, starved transgenic mice showed levels of GK activity fourfold higher than those of starved control and similar to those of fed control. This activation of GK led to an increase in the intracellular concentration of glucose 6‐phos‐phate, which was also related to an induction of glycogen accumulation. In addition, L‐pyruvate kinase (L‐PK) activity increased in transgenic mice, which when starved showed similar levels of activity to control fed mice. The induction of L‐PK caused an increase in the hepatic lactate concentration. Furthermore, hepatocytes in primary culture from transgenic mice incubated with 20 mM glucose produced levels of lactate threefold higher than controls, but no difference was noted when the hepatocytes from control and transgenic mice were incubated with 2 mM glucose. These results demonstrated in vivo that the activation of GK is a rate‐limiting step in the induction of glycolysis and glycogen synthesis. These changes in liver glucose metabolism led to a marked reduction in blood glucose (30%) and insulin (40%) concentrations. Furthermore, transgenic mice showed lower levels of blood glucose after an intraperitoneal glucose tolerance test, indicating that GK overexpression caused an increase in blood glucose disposal by the liver. All these findings show the key role of liver GK in the control of whole‐body glucose homeostasis. —Ferre, T. , Riu, E. , Bosch, F. , Valera, A. Evidence from transgenic ‐mice that glucokinase is rate limiting for glucose utilization in the liver. FASEB J. 10, 1213‐1218 (1996)
A Deep Learning Model with Hierarchical LSTMs and Supervised Attention for Anti-Phishing

Anti-phishing aims to detect phishing content/documents in a pool of textual data. This is an important problem in cybersecurity that can help to guard users from fraudulent information. Natural language processing (NLP) offers a natural solution for this problem as it is capable of analyzing the textual content to perform intelligent recognition. In this work, we investigate state-of-the-art techniques for text categorization in NLP to address the problem of anti-phishing for emails (i.e, predicting if an email is phishing or not). These techniques are based on deep learning models that have attracted much attention from the community recently. In particular, we present a framework with hierarchical long short-term memory networks (H-LSTMs) and attention mechanisms to model the emails simultaneously at the word and the sentence level. Our expectation is to produce an effective model for anti-phishing and demonstrate the effectiveness of deep learning for problems in cybersecurity.
Preconditioning and reperfusion arrhythmias in the isolated rat heart: true protection or temporal shift in vulnerability?

OBJECTIVE The relationship between arrhythmia severity during reperfusion and the duration of preceding ischaemia is bell shaped. Although ischaemic preconditioning can protect against reperfusion induced arrhythmias it is not clear if this is achieved by a true reduction in arrhythmia severity or by a temporal shift in the bell shaped relationship occurring as a consequence of increased ischaemic tolerance. METHODS Isolated rat hearts (n = 12 per group) were Langendorff-perfused with whole blood from a support rat. Regional ischaemia and reperfusion were induced using a ligature around the left main coronary artery. Cardiac rhythm was recorded continuously. RESULTS Repeated cycles of preconditioning (5 min ischaemia and 5 min reperfusion) led to a progressive reduction in the incidence of reperfusion induced ventricular fibrillation following 10 minutes of ischaemia (92%, 66%, 42%, and 8% following 0, 1, 2, and 3 cycles respectively). Three cycles of preconditioning reduced the incidence of reperfusion induced ventricular fibrillation after each of 10 (83% to 17%; p < 0.05), 15 (92% to 42%; p < 0.05), 20 (67% to 25%), 30 (33% to 0%), and 40 (25% to 0%) minutes of ischaemia. Preconditioning also led to a reduced incidence of reperfusion induced ventricular tachycardia following 10 minutes of ischaemia (100% to 42%; p < 0.05). There was no evidence of a temporal shift in the bell shaped relationships: peak incidences of reperfusion induced ventricular fibrillation and ventricular tachycardia each occurred after 15 minutes of ischaemia in both control and preconditioned groups. CONCLUSIONS In isolated blood perfused rat hearts serial preconditioning cycles provide cumulative protection against reperfusion induced ventricular arrhythmias. This protection occurs over a wide range of ischaemic durations without altering the temporal relationship between the duration of ischaemia and arrhythmia severity. This may indicate that antiarrhythmic protection is not a consequence of anti-ischaemic mechanisms.
The epidemiology and clinical findings of colorectal cancer in Iran.

BACKGROUND This study was performed to evaluate the prevalence, clinical features and management of patients with colorectal cancer (CRC) in Iran. METHODS All cases of CRC presented to a principal referral University hospital (SGH) for cancers in Teheran, Iran between June 20, 2000 and January 3, 2003 were retrospectively reviewed. RESULTS A total of 200 patients were included. 114 patients (57%) were male and 86 were female (43%). Age ranged from 13-90 years with a mean of 55.15 +/- 14.5. Among these patients, 16.5% were less than 40 years of age. The tumors were categorized according to their distribution as appendix (n=4), cecum ( n=7), right colon (n=1), hepatic flexure (n=2), transverse colon (n=19), splenic flexure (n=3), left colon (n=6), sigmoid ( n=16), rectum (n=117), rectosigmoid and rectal lesions (n=16), and colorectal lesions without known locations (n=9). Non-mucinous adenocarcinoma (AC) was the most common histological type (n=181, 90%), followed by mucinous AC (n=15), squamous cell carcinoma (n=1), carcinoid (n=1), melanoma (n=1) and signet ring carcinoma (n=1). The most common presenting symptom was rectal bleeding (n=68, 34.5%). Younger patients had a greater preponderance of mucinous AC (p=0.008) and generally underwent more extensive chemotherapy as seen with more usage of 5-Fluorouracil (p=0.05). CONCLUSIONS We have had few reports with reference to the epidemiology of CRC in Iran since 1977. The current data suggest a younger age distribution for CRC. We found no significant difference between age, gender and type of cancer with subsite distribution. Distal CRC was more prevalent. Among patients, 30.5% were diagnosed by screening studies.
The debate on the future of the population census: Relevance for South Africa?

ABSTRACT The cancellation of the Canadian census long-form questionnaire in 2010 and its subsequent reinstatement in 2015 resulted in a vigorous international debate on the future of the mandatory census. Questions concerning state invasions of personal privacy, party political interference and public trust and cooperation in state data-gathering were raised. As a result, alternative forms of demographic data collection were explored and the experiences of other countries examined. National population registers and non-mandatory surveys offered alternatives, but each had their own distinct disadvantages. South Africa has continued to conduct mandatory detailed censuses since 1994 and the enumerations have encountered little political opposition because they are presented as essentially nation-building exercises providing credible and relevant data, upon which national policies may be based and monitored. At present there is little incentive to change the current format of statistical collection in the absence of a viable alternative.
Surgical and Non-Surgical Management and Treatment of Glioblastoma: I. Primary Tumors

Glioblastoma (GB), also known as Glioblastoma multiform (GBM), is the most common primary brain tumor in adults. It remains an unmet need in oncology. It is the most aggressive and most common brain cancer, the second most common after meningioma, representing 15 % of brain tumors. Its annual incidence is ~ 3.19 cases per 100,000 population with the average age at diagnosis being 64 years. It occurs more commonly Abstract
A novel wideband Chebychev tapered slot antenna using broadband CPW to slotline transition

Efficiency, bandwidth, light weight and geometric simplicity are the most cruccial requirements for antennas designed for some specific applications like the emergence of new application areas in the fixed and mobile communications. One of the most desirable candidates catering for these demands is the tapered slot antenna (TSA), which belongs to a group of endfire traveling wave antennas. The most attractive of the TSAs in contrast to other kinds of planar antennas are that it can work over a large frequency bandwidth, low cost, easy fabrication, low profile and produce a symmetric endfire beam with appreciable gain and low sidelobes. In this paper, a new configuration of Tapered Slot Antenna (TSA) with an improved radiation pattern is presented. The new design has tapered section expressed by the Chebychev function. In addition, a new technique, using CPW to slotline transition in order to couple the CPW to the slotline input of the Chebychev antenna is introduced. This transition offered the advantage of an inline port geometry suitable for array applications.