Miracle-dz/UniFAR-FTUs huggingface dataset:
Gender, nature and nation: Resource nationalism on primary sector reality TV

A number of media companies in the United States broadcast reality TV series that chronicle lives, conflicts and economic highs and lows in the primary sector of the economy. This is curious from a cultural standpoint because employment in the primary sector has plateaued, and, in many regions, is in active decline. This paper examines primary sector reality TV series about fishing, logging and mining televised to audiences in the United States by broadcast networks Discovery and National Geographic. Using discourse and visual analysis, we deconstruct prominent nature–society representations in a sample of 100 episodes systematically selected from 15 different series. Three points emerge from the data and are generalizable across the series. First, nearly all characters are male, and storylines suggest that successful men are competitive, strong and brave. Second, hegemonic masculinity is made legible in contrast to a feminized nature that is almost always suggested to be acting against male protagonists. Third, US symbolism is common, and Americans are presented as ideally skilled and situated to exploit natural resources within and beyond domestic borders. Overall, the series mediate a highly gendered nature–society relation that weaves together hegemonic masculinity and resource nationalism. We conclude that viewers – many of whom will have little personal experience of primary sector work – are invited to relate with concern for the ‘real-life’ characters and with anxiety for the future of a specific identity and associated set of labour and consumption practices.
Understanding multiple medication use in people with dementia. A pharmacoepidemiology study of prevalence, intervention and associated harms.

Background: Around 70% of people with dementia live with comorbidities and are subsequently prescribed multiple medications (polypharmacy). Some medicines are considered ‘potentially inappropriate’ when prescribed to older and cognitively impaired adults. Cognitive impairment, dementia and frailty may influence the prevalence and associated effects of polypharmacy and potentially inappropriate medicines (PIMs). Aims: To estimate prevalence trends of polypharmacy and PIMs (antipsychotics, antidepressants, benzodiazepines, anticholinergics and proton pump inhibitors) among people with dementia. To identify associated factors, including the impact of care and medication reviews and to understand the impact of polypharmacy, PIMs and frailty on health in people with cognitive impairment. Methods: Two cohorts were analysed, including primary care electronic medical records (Clinical Practice Research Datalink, 2015-2017) (n=22,448) and the Cognitive Function and Ageing Study (2008-2011) (n=1,154). Results: Polypharmacy and PIMs were prevalent in people with dementia and cognitive impairment. On average, people with dementia were prescribed 8 medications, 30% were prescribed inappropriate PPIs, 17% anticholinergics, 8% antipsychotics, 7% tricyclics and 4% of people with cognitive impairment were prescribed benzodiazepines. Dementia annual reviews and medication reviews were associated with medicines optimisation. Prevalence of PIM was greater in care homes and a medication review in a care home was associated with reduced use of PIMs. Polypharmacy was associated with worse survival. PIMs were not associated with worse survival, with the exception of antipsychotics (adjusted HR=3.24, 95% CI=1.83-5.73). Being cognitively impaired and frail was associated with worse survival overall but frailty was not found to moderate the relationship between polypharmacy, PIMs and survival. Conclusions: Few prescribing guidelines specifically address medicines use in people with cognitive impairment or dementia, despite the prevalence of polypharmacy and PIMs. The number of medicines prescribed should be carefully monitored to reduce harm. Incorporating medication reviews into annual dementia care reviews may optimise prescribing and identify people at increased risk of adverse effects. The findings from this thesis will improve understanding and support the optimisation of medicines for people living with dementia.
lncRNA SNHG7 promotes tumorigenesis of nasopharyngeal carcinoma via epithelial-to-mesenchymal transition

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors. Studies have indicated that long noncoding RNAs (lncRNAs) function as important regulators in progression of tumorigenesis. In this study, lncRNA small nucleolar RNA host gene 7 (SNHG7) was selected to identify how it functioned in the development of NPC. Real-time quantitative polymerase chain reaction (RT-qPCR) was performed to detect SNHG7 expression in paired NPC patient tissue samples and cell lines. The role of SNHG7 in the metastasis of NPC was detected through scratch wound assay and Transwell assay. RT-qPCR and western blot assay were used to discover the function of SNHG7 in epithelial-to-mesenchymal transition (EMT) process. Tumor metastasis assay was also performed in vivo. In this study, RT-qPCR results showed that SNHG7 expression in NPC samples was remarkably higher when compared with that in adjacent ones. Cell invasion and cell migration of NPC were inhibited due to silence of SNHG7 and were promoted due to overexpression of SNHG7. Moreover, results of further experiments revealed that the EMT-related proteins were regulated via knockdown or overexpression of SNHG7 in NPC. Furthermore, tumor metastasis of NPC was inhibited via knockdown of SNHG7 and was enhanced via overexpression of SNHG7 in nude mice. These results indicate that SNHG7 enhances NPC cell invasion and cell migration by eliciting the EMT process.
Botulinum toxin A versus percutaneous tibial nerve stimulation in idiopathic overactive bladder: a randomized trial

The uprising number of people suffering from overactive bladder, has made evident the need of new treatments to tackle the condition in patients refractory to oral therapies. The development of third line therapies for overactive bladder, has given a lot of patients an opportunity to gain quality of life. However, these treatments can associate severe side effects, which compels us to be cautious with its prescription. This study compares the efficacy of intradetrusor Botox ® injections and percutaneous tibial nerve stimulation measured in quality of life. In addition, an analysis of the security, convenience and cost-effective is included. We designed multicenter clinical trial, where sequential sampling will be used to enroll a total of 234 individuals. By randomization, we will allocate the subjects in a group for botulinum toxin or a group for tibial nerve stimulation. The collaboration of seven hospitals will be required to perform this evaluation. Our principal endpoint will be the punctuation in a disease-specific questionnaire after 12 months. The follow up will be conducted at 3, 6, 9 and 12 months with urodynamic measures, symptom reports and quality of life questionnaire
Perceptions of comparative optimism and perceptions of career success: Experimental evidence for a bidirectional effect

ABSTRACT Audiences generally view people who display more (versus less) comparative optimism more favorably. We explored whether audiences view a target who displays comparative optimism as more professionally successful, and conversely, whether they view a target who is more professionally successful as more comparatively optimistic. In Study 1, participants estimated the career success of a target that varied in level of comparative optimism. In Study 2, participants estimated the level of comparative optimism of a target that varied in career success. The results revealed that observers rated comparative optimists as likely to have successful careers, and rated people with successful careers as likely to display comparative optimism. Inferences about personal agency account for the bidirectional relationship.
A Theory and Framework for Navigating Entangled Consultations: Using Case Studies to Find Common Ground

Instructional consultations are often challenging, but some are frustrating for reasons that are unrelated to teaching per se. There is a prolific literature on consultations, but most of it assumes that the instructor is ready, willing, and able to take suggestions. In the authors’ experience, this is not always the case, and consultations can become “entangled” in a web of interacting, compounding factors exogenous to teaching. They analyze entangled consultations to identify common themes and strategies for responding appropriately. The compounding factors that the authors consider include defensiveness, personal problems, cultural reasons, or departmental politics. The authors also present four case studies condensed from their own experiences in entangled consultations and offer suggestions for using them to build the scholarship of educational development.
Prior employment as a causal mechanism within entrepreneurial ecosystems

ABSTRACT The entrepreneurial ecosystems literature lists numerous factors, emphasizing their interactions. However, there is limited empirical literature exploring the causal mechanisms, nor an understanding of the relative importance of these factors. This paper places the entrepreneur at the centre of the analysis by constructing a career history network of over 2100 Irish high-tech entrepreneurs. It finds that prior employment experience can be used to measure the prominence of different actors anticipated in the entrepreneurial ecosystem literature. Regional universities play an anchor role within each regional entrepreneurial ecosystem. Universities are indirectly connected to other organizations to form an integrated network that supports high-tech entrepreneurship. This approach may be used to assess and motivate interventions to support integration and anchor organization establishment that enhances regional entrepreneurial activity.
Urban sustainable stormwater management described from a governance perspective – challenges and interdependencies

Conventional stormwater management systems have been criticised as being unsustainable due to increased flood risks downstream and water quality degradation in the receiving water bodies. Use of green infrastructure to manage stormwater has long been suggested, but implementation is still mainly limited to pilot projects. Based on a systematic literature review and two qualitative case studies, governance challenges and their interdependencies influencing implementation of sustainable stormwater management (SSM) were examined. In the literature review, nineteen governance challenges hindering SSM implementation from a global perspective were identified. Case study 1 examined governance factors influencing SSM implementation from a local perspective under two distinct governance structures, namely, hierarchical in China and non-hierarchical in Sweden. Governance factors found to influence SSM implementation were mapped into causal loop diagrams (CLD) to describe the governance factor interdependencies. Case study 2, investigating the Sponge Cities initiative in China, identified governance challenges influencing a national SSM policy being implemented locally. It was found that conventional grey infrastructure still plays a significant role in the Sponge Cities initiative due to lack of space, a general lack of knowledge of SSM and prioritization of quantifiable objectives within a short time-frame. The thesis provides an overview of governance challenges and their interdependencies influencing SSM implementation, as well as a visual tool (SSM-CLDs) to help local authorities and non-governmental stakeholders understand the complexities of SSM from a governance perspective.
Challenges in Diagnosis and Treatment of Recurrent Aphthous Stomatitis

Modern medicine and advanced research nowadays allow clinicians to correctly diagnose and treat recurrent aphthous stomatitis, which can impact affected individuals functionally, psychosocially and economically. This review has been designed to investigate the diagnosis and treatment options of RAS based on the etiopathogenesis of the aphthous ulcers. The success of treatment depends on the timely and correct diagnosis of the lesions. Although pin-pointing a precise etiological factor is difficult, various plausible of them are discussed in this review. Treatment modalities allow efficient and effective palliative care, along with rapid healing of affected mucosa. Further research should be made to isolate the aetiology of RAS for every case and the efficiency of conventional and unconventional treatment options, and possible side effects of such.
A comparative evaluation of King Vision video laryngoscope (channelled blade), McCoy, and Macintosh laryngoscopes for tracheal intubation in patients with immobilized cervical spine

Background: Cervical spine immobilization results in a poor laryngeal view on direct laryngoscopy leading to difficulty in intubation. This randomized prospective study was designed to compare the laryngeal view and ease of intubation with the Macintosh, McCoy, and King Vision video laryngoscopes in patients with immobilized cervical spine. Method: Ninety adult patients of ASA grade I-II with immobilized cervical spine using manual inline axial cervical spine stabilization technique, undergoing elective cervical surgery were enrolled. The patients were randomly allocated into three groups to achieve tracheal intubation with Macintosh (MAC group n=30), McCoy (MCC group n=30), or King Vision video laryngoscopes (KVL group). When the best possible view of the glottis was obtained, the Cormack-Lehane laryngoscopy grade and the percentage of glottic opening (POGO) score were assessed. Other measurements included the intubation time, the intubation difficulty score, and the intubation success rate. Haemodynamic parameters and any airway complications were also recorded. Result: King Vision video laryngoscope reduced the intubation difficulty score, improved the Cormack and Lehane glottic view, and the POGO score compared with the McCoy and Macintosh laryngoscopes. The first attempt intubation success rate was also high in the King Vision video laryngoscope group. However, there were no statistically significant differences in the time required for successful intubation and the overall success rates between the devices tested. No dental injury or hypoxia occurred with either device. Conclusion: The use of a King Vision video laryngoscope resulted in better glottis visualization, easier tracheal intubation, and higher first attempt success rate as compared to Macintosh and McCoy laryngoscopes in immobilized cervical spine patients.
Der familiäre Generationenvertrag

Der Beitrag befasst sich mit den Deutungen junger Erwachsener von Fursorge und beschaftigt sich mit ihren Ausfuhrungen zum Generationenvertrag in der Familie. Er formuliert zu Beginn die These, dass die Ausformung der Eltern-Kind-Beziehung Auswirkungen auf die zukunftige Pflege der Eltern durch die Kinder habe. Das Datenmaterial lasst jedoch keine Ruckschlusse auf diese These zu. Es wird sodann mit den Erfahrungen und dem Wissen beschaftigt, welches die jungen Erwachsenen im Feld der Pflege erhalten. Die neue These lautet demnach, dass der Erfahrungs- und Wissenshintergrund Auswirkungen auf die Formulierungen uber die zukunftige Pflege der eigenen Eltern haben.
Organic Food Consumption: The Relevance of the Health Attribute

During the last decades, organic food products have become the main sustainable alternative to conventional food consumption. Among the several organic food attributes that consumers recognize in organic food, healthiness has been reported as the primary motivation to buy products certified as organic. The objective of the current study is to assess the relative weight of the health attribute among other recognized organic food attributes. To achieve this aim, a multiple price list (MPL) methodology is adopted to elicit consumers’ Willingness to Pay (WTP) for organic extra virgin olive oil (EVOO). Findings show that the contribution of the health attribute to determine the average premium price for organic EVOO is 78.9% of its total premium price. The study generates managerial implications to promote further expansion of the organic food market.
Efficacious Naturally Occurring Anti-cerebral Ischaemia Extracts, Compounds and Formulations Data from Animal Models

Abstract Stroke is known to be a major cause of mortality across the world. One of its type, cerebral ischemia (CI), caused due to reduction of blood flow to the brain, is being studied extensively nowadays in the field of herbal drug discovery in order to minimize the side effects of conventional medication and thereby eliminate the limitations of pharmacological treatment. This review on anti-cerebral ischemia therapeutics from nature uses electronic search engines such as Pubmed, Google Scholar, Science Direct, Springer, Jstor etc. with appropriate search strings. The World Health Organization (WHO) places the global occurrence of cerebral ischemia at around 200 cases per 100,000 inhabitants, although the data varies among countries. Prevalent treatment includes drugs of thrombolytic, neuroprotective, anti-coagulatory, anti-platelet and vasodilatory nature. Side effects of these drugs have led to the discovery of herbal treatment which includes anti ischemic plant derived phytochemicals, plant crude extracts and herbal formulations. In this present review, a number of plant extracts, isolated compounds and herbal preparations with their respective ethnopharmacological backgrounds have been reported against several in vivo CI models modulating an array of biochemical and molecular markers associated with stroke. Significant efforts are needed to ensure that the new herbal treatments being discovered can be administered safely to humans. Human clinical trials should be done to provide greater ability to generalize in vivo results in the therapy of acute cerebral ischemia.
Analisis Penerimaan Audit Software Bagi Auditor Eksternal Dengan Menggunakan Pendekatan Technology Acceptance Model (Tam)

Technology Acceptance Model (TAM) merupakan suatu model yang digunakan untuk mengetahui tingkat penerimaan seseorang atau pemakai terhadap penggunaan teknologi. Penelitian ini bertujuan untuk menganalisis pengaruh terhadap tingkat penerimaan audit software bagi auditor eksternal dengan menggunakan model TAM. Adapun konstruk model TAM yang digunakan dalam penelitian ini terdiri dari 4 (empat) konstruk utama, yaitu: perceived usefulness (persepsi kegunaan) , perceived ease of use (persepsi kemudahan penggunaan), attitude toward using (sikap terhadap penggunaan) dan penerimaan audit software . Penelitian ini dilakukan dengan menggunakan kuesioner online dan disebarkan kepada auditor di Kantor Akuntan Publik (KAP) wilayah DKI Jakarta. Teknik pengumpulan data menggunakan purposive sampling dan menghasilkan sampel akhir sebanyak 91 (sembilan puluh satu) responden. Hipotesis dalam penelitian ini menggunakan model analisis statistik persamaan struktural (SEM) dengan bantuan program WarpPLS 3.0. Hasil penelitian menunjukkan bahwa variabel persepsi kemudahan penggunaan berpengaruh signifikan dan positif terhadap variabel persepsi kegunaan, variabel persepsi kemudahan penggunaan dan persepsi kegunaan berpengaruh signifikan dan positif terhadap variabel sikap terhadap penggunaan dan variabel persepsi kegunaan dan sikap terhadap penggunaan berpengaruh signifikan dan positif terhadap variabel penerimaan audit software . Dari hasil penelitian dapat disimpulkan bahwa tingkat penerimaan audit software adalah sangat tinggi yang didasari oleh persepsi individu tentang kegunaan dan kemudahan audit software . Hal ini juga menunjukkan bahwa auditor sangat menerima dengan positif terhadap perkembangan teknologi di bidang auditing . Saran untuk penelitian selanjutnya adalah melakukan penelitian terkait perkembangan teknologi baru dalam bidang auditing yang memasuki tahap implementasi era revolusi industri 4.0.
Gastroenterology needs its own ImageNet

In a period spanning less than a decade, deep learning with Convolutional Neural Networks (CNNs) has become the standard for Artificial Intelligence (AI) applications. While most of the key concepts were introduced decades ago, the two driving forces behind its success have only started building momentum at the dawn of this century: (I) an exponential increase in computational power and (II) the growing availability of large sets of labeled data. These two developments reached critical mass first in speech recognition (1), and later in computer vision, with the introduction of AlexNet (2): the first deep learning architecture to win the ImageNet Large Scale Visual Recognition Challenge (ILSVRC) (3).
PREDICTIVE RISK FACTORS FOR UPPER GASTROINTESTINAL BLEEDING WITH SIMULTANEOUS MYOCARDIAL INJURY

Background and Rationale:Myocardial injury after UGIB is frequently ignored because the signs and symptoms may be overshadowed by severe UGIB. The aims of this study were to investigate the predictive risk factors of simultaneous upper gastrointestinal bleeding (UGIB) and myocardial injury using parameters including troponin I (TnI); and evaluate the epidemiology of this syndrome. Subject and methods:This study was a case-control study carried out at the gastrointestinal subunit of medical intensive care unit of Internal Medicine department, Faculty of Medicine, Zagazig University.One hundred and five patients were included in this work presenting with UGIB. All participants were subjected to thorough history taking, clinical examination. Routine investigations , abdominal ultrasonography ,upper GIT endoscopy and studies of myocardial injury including ECG, echocardiography and cadiac enzymes includingCK, CK-MB and TnI. Results:UGIB patients with a history of liver cirrhosis and more than three cardiac risk factors including systemic hypertension, smoking , BMI and hypertriglyceridaemia had a high risk of simultaneously developing myocardial injury. Longer hospital stay was found in those patients. Other factors including age, gender, the color of nasogastric tube irrigation fluid, history of nonsteroidal anti-inflammatory drug use, octeriotide or terlipressin administration, vital signs, and creatinine recorded at the ED were not significant predictors. Conclusions: UGIB patients with a history of liver cirrhosis and more than three cardiac risk factors had a high risk of simultaneously developing myocardial injury. Monitoring ECG and cardiac enzymes, including TnI, are recommended in highrisk patients, even if no chest complaints are present. Key words: myocardial injury, troponin I, upper gastrointestinal bleeding
Engineering Functional Pseudo-Islets of Defined Sizes from Primary Murine Cells Using PEG Microwell Devices

A major limitation of islet transplantation as a therapy for treating Type 1 Diabetes is eventual graft failure, which can be partially attributed to islet cell death. When cultured in vitro, cells in the center of large islets show increased necrosis and exhibit decreased viability and insulin secretion compared to smaller islets. Given the necessity of β-cell-to-β-cell coupling for the physiological response to glucose, a technique to re-aggregate primary islet cells or cells derived from progenitor cells into small clusters of defined sizes may prove advantageous for promoting function upon transplantation. Here, hydrogel microwell arrays were utilized to generate 3-dimensional pseudo-islets from primary murine islets. Pseudo-islets ranged from 50 to 100 μm in diameter as controlled through the microwell dimensions, and contained β-, α-, and δ-cells with ratios similar to those in whole murine islets. Over two weeks in culture, pseudo-islets remained highly viable and responsive to glucose. Intracellular calcium flux showed more robust and coordinated dynamics at high glucose and decreased activity at low glucose compared to age-matched wild-type islets. Therefore, microwell devices can control the aggregation of cells isolated from primary islets to produce islet-like clusters that are functionally similar to freshly isolated islets, and may provide a technique to create improved cellular therapies for Type 1 Diabetes.