Miracle-dz/UniFAR-FTUs huggingface dataset:
Pilot study of vitaxin—an angiogenesis inhibitor—in patients with advanced leiomyosarcomas

Leiomyosarcomas comprise one of the common histologic subsets of a rare and heterogenous group of tumors called soft tissue sarcomas. Leiomyosarcomas have a variable biologic behavior depending on their site of origin. Tumors originating in the gastrointestinal (GI) tract belong to a broader class of tumors called GI stromal tumors and are refractory to standard chemotherapeutic agents such as doxorubicin and ifosfamide. Those originating outside the GI tract, especially the ones arising from the uterus, conversely are indeed sensitive to these standard chemotherapeutic agents. Unfortunately, the options for salvage chemotherapy after failure of initial therapy with standard agents are very limited, and therefore newer strategies need to be investigated aggressively. Angiogenesis is critical for the growth and development of tumor. It is a complicated process initiated by the expression of several proteases and growth factors acting as angiogenic molecules. The migration of endothelial cells is dependent on their adhesion to extracellular matrix proteins, such as vitronectin, through a variety of cell adhesion receptors known as integrins. The role of the integrin avb3 in the angiogenic process has been established. Blocking neoangiogenesis by inhibiting the anb3 integrin therefore can result in antitumor activity. We tested Vitaxin, a humanized monoclonal antibody targeted against the endothelial cell anb3 integrin in a group of patients with advanced leiomyosarcomas with an intent to test feasibility and safety and to better estimate the antitumor activity that was observed in one patient with liver metastases from a leiomyosarcoma in the Phase I study of Vitaxin performed at the Sidney Kimmel Cancer Center in San Diego, California. Vitaxin was administered intravenously as an outpatient at a fixed dose of 0.25 mg/kg over 9
Determinants of compliance with iron supplementation among pregnant women in Senegal

Abstract Background Community iron supplementation programmes for pregnant women have lacked effectiveness, partly because of low compliance. Objective To determine factors that influence compliance among pregnant women in Senegal. Design Two hundred and twenty-one pregnant women, recruited from six health centres in Dakar during their first prenatal visit, were randomly assigned to receive either a prescription to purchase iron/folic acid tablets (control, n = 112) to be taken daily, according to official policy, or to receive free tablets (treatment, n = 109). Compliance was assessed 20 weeks after enrolment through interviews and pill count. Women with low or high compliance (<70% or ≥70%) were asked to explain what influenced their adherence to supplementation. Results Overall compliance was 69%; it was significantly higher in the treatment than in the control group (86% vs. 48%; P < 0.0001). Women with high compliance (58%) were motivated by: (1) the perception of improved health upon taking the tablets (treatment = 24%, control = 10%); (2) the insistence by midwives that they take the tablets; and (3) the mention that the tablets would improve health. Women with low compliance (42%) reported: (1) the experience of side-effects that they associated with the tablets (treatment = 13%, control = 14%); (2) misunderstanding that they needed to continue taking the tablets throughout pregnancy (treatment = 0%, control = 18%); and (3) forgetfulness. Conclusion Compliance with iron/folic acid supplementation in Senegal can be increased by providing women with clear instructions about tablet intake and educating them on the health benefits of the tablets.
Transcriptional Activation and Nuclear Targeting Signals of the Human Androgen Receptor *

The androgen receptor (AR) is a signal-transducing protein required for sexual differentiation, development, and expression of the male phenotype. A series of human AR deletion mutants were created either by site-directed mutagenesis using restriction enzyme digestion, the polymerase chain reaction, or, for a series of unidirectional NH2-terminal deletions, exonuclease I11 digestion. Receptor mutants were expressed in monkey kidney COS cells as truncated AR proteins between 20 and 107 kDa as revealed on immunoblots, where wild type AR was a doublet of 114 and 108 kDa. Subcellular localization by immunocytochemical staining demonstrated androgen-dependent nuclear uptake of AR from a perinuclear region of the cytoplasm. A nuclear targeting signal similar in sequence and position to the glucocorticoid receptor and homologous to the SV40 large T antigen was required for androgeninduced nuclear uptake of wild type AR. AR mutants lacking the NH2-terminal and/or steroid binding domains were constitutively nuclear with reduced transcriptional activity. Transcriptional activation by wild type AR was androgen-dependent in cotransfection studies of CV1 cells using the chloramphenicol acetyltransferase reporter gene linked to the mouse mammary tumor virus promoter. Deletion mutagenesis revealed within the NH2-terminal region a domain required for full transcriptional activity and within the steroid binding domain, an inhibitory function, deletion of which yielded a constitutively active receptor. Inhibition of wild type AR by coexpression with an inactive NHa-terminal fragment suggested competition for nuclear factors required for transcriptional regulation. These studies demonstrate concerted interplay among the domains of the AR protein in regulating gene transcription.
ON MARKOV AND KOLMOGOROV MATRICES AND THEIR RELATIONSHIP WITH ANALYTIC OPERATORS

In this article, the relationship between sub–Markov and sub–Kolmogorov matrices is investigated. In addition some results about analytic operators and analytic semigroups are exhibited. In particular it is shown that analyticity properties have ramifications for limiting properties of bounded analytic semigroups. These result has some interesting consequences for matrices with Markov and Kolmogorov properties.
Modeling of diffusion process in p-n junction diode using matrix rational approximation

The diffusion process in p-n junction diodes is modeled using the matrix rational approximation. The diffusion process is governed by the carrier continuity equation which is equivalent to an RCG transmission line. The matrix rational approximation here is used to provide a lumped network model of the RCG transmission line preserving the passivity. In an example, comparable accuracy with mixed-level circuit and device simulation and superior efficiency to different passive models are observed.
Bounding proxies for shape approximation

Many computer graphics applications use simpler yet faithful approximations of complex shapes to conduct reliably part of their computations. Some tasks, such as physical simulation, collision detection, occlusion queries or free-form deformation, require the simpler proxy to strictly enclose the input shape. While there are algorithms that can output such bounding proxies on simple input shapes, most of them fail at generating a proper coarse approximant on real-world complex shapes, which may contain multiple components and have a high genus. We advocate that, before reducing the number of primitives to describe a shape, one needs to regularize it while maintaining the strict enclosing property, to avoid any geometric aliasing that makes the decimation unreliable. Depending on the scale of the desired approximation, the topology of the shape itself may indeed have to be first simplified, to let the subsequent geometric optimization be free from topological locks. We propose a new bounding shape approximation algorithm which takes as input an arbitrary surface mesh, with potentially complex multi-component structures, and generates automatically a bounding proxy which is tightened on the input and can match even the coarsest levels of approximation. To sustain the nonlinear approximation process that may eventually abstract both geometry and topology, we propose to use an intermediate regularized representation in the form of a shape closing, computed in real time using a new fast morphological framework designed for efficient parallel execution. Once the desired level of approximation is reached in the shape closing, a coarse, tight and bounding polygonization of the proxy geometry is extracted using an adaptive meshing scheme. Our underlying representation is both geometry- and topology-adaptive and can be optionally controlled accurately by a user, through sizing and orientation fields, yielding an intuitive brush metaphor within an interactive proxy design environment. We provide extensive experiments on various kinds of input meshes and illustrate the potential applications of our method in scenarios that benefit greatly from coarse, tight bounding substitutes to the actual high resolution geometry of the original 3D model, including freeform deformation, physical simulation and level of detail generation for rendering.
ÍNDICES DE “MARK UP” EN EL MERCADO ELÉCTRICO MAYORISTA DE ARGENTINA

La intencion de este trabajo es analizar el grado de competencia en el sector de generacion electrica para cuatro periodos estacionales comprendidos entre 1999 y 2001. Mediante la simulacion de despachos teoricos se trata de determinar un escenario en el cual las firmas no puedan tener conductas anticompetitivas. Este “benchmark” es luego testeado con el despacho real por medio de Indices de Lerner. Los indices obtenidos, si bien no pueden ser usados directamente para diagnosticar poder de mercado, muestran persistentemente desvios del ideal de competencia perfecta.
A Photochemical Theory of Tropospheric Ozone

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Effect of Azotobacter on Growth and Yield of Maize

A field experiment was conducted to study the effect of Azotobacter on growth and yield of maize (variety Rampur composite) at farmland of National Maize Research Program, Rampur, Chitwan, Nepal during the winter season of 2007-08 and 2008-09. The experiment was laid out in randomized complete block design with eight treatments each replicated three times. The treatments were control, 120:60:40 kg NP 2 O 5 K 2 O ha -1 , Azotobacter seed inoculation, Azotobacter soil application, Azotobacter +10 t FYM ha -1 , 10 t FYM ha -1 , 120:60:40 kg NP 2 O 5 K 2 O ha -1 + Azotobacter, 120:60:40 kg NP 2 O 5 K 2 O ha -1 + Azotobacter + 10 t FYM ha -1 . Analysis of variance showed that grain yield, plant height, ear height, ear length, kernel per rows and 1000 grain weight were significantly affected with treatments. Only inoculation of Azotobacter increased 15 to 35% grain yield over non inoculated treatments. The benefit of Azotobacter inoculation was higher in the absence of chemical fertilizer application. DOI: http://dx.doi. org/10.3329/sja.v11i2. 18409 SAARC J. Agri. , 11(2): 141-147 (2013)
Robust Automatic Modulation Classification Under Varying Noise Conditions

Automatic modulation classification (AMC) plays a key role in non-cooperative communication systems. Feature-based (FB) methods have been widely studied in particular. Most existing FB methods are deployed at a fixed SNR level, and the pre-trained classifiers may no longer be effective when the SNR level changes. The classifiers may also need to be re-trained to be suitable for the varying channel environment. To address these problems, a robust AMC method under varying noise conditions is proposed in this paper. The method attempts to select noise-insensitive features from a large feature set to ensure that the trained classifiers will be robust to SNR variations. First, a feature set consisting of 25 types of features is extracted, and 4 features that are insensitive to noise are chosen through a feature selection method based on rough set theory. The generalizability of an SVM classifier trained on the 4 chosen features is evaluated based on numerical results. The classification accuracy remains reasonable when the SNR varies between 5 and 20 dB, indicating that the proposed method can be deployed under varying noise conditions.
[Genome-wide non-sequencing strategies for bacterial genome comparison: the necessity and an analysis of the variable bacterial world].

A tremendous success in bacterial genome sequencing has been achieved during the recent years; it resulted in making available, for analysis, multiple sequences of different bacterial genomes, including such pathogens as causative agents of syphilis, typhus, and tuberculosis as well as such organisms like archaebacterias living under extreme conditions. A comparative analysis of bacterial genomes leads to conclusions, which have a general biological value, and, in particular, to the conclusions about mechanisms and evolution rate as well as about the variability of genomes and interrelation between organisms and their habitat. On the other hand, the analysis reveals specific features of separate bacterial species responsible for their pathogenicity and ability to avoid the destruction of the host immune system as well as for adaptation to exist within a certain ecological niche. However, the variability of bacterial genomes is so high that methods, which enable to evaluate the variability without full genome sequencing, are needed to depict adequately the evolution and ecological characteristics of the prokaryotic world and to develop new effective therapeutics and diagnostic tools. The survey covers two approaches to such comparative analysis, i.e. DNA arrays and subtractive hybridization. The advantages and disadvantages of each approach are discussed and the necessity in a new approach combining the positive features of the two mentioned approaches is substantiated.
Komplikationen beim Sjögren Syndrom

Zusammenfassung Das Sjögren-Syndrom ist eine entzündlichrheumatische Erkrankung, die zu einer Reihe von Komplikationen im internistischen Bereich führen kann, insbesondere zu erhöhten Risiken für Non-Hodgkin-Lymphome, Vaskulitiden, zu erhöhter Infektionsneigung, Immunzytopenien und Thromboseneigung. In der Geburtshilfe zeigen sich vermehrt fetomaternale Syndrome wie angeborener Herzblock oder neonataler Lupus erythematodes, während im Bereich der Neurologie u. a. sensible Neuronopathie und Demyelinisierungen vorkommen können. Aktuelle Aspekte in der Patientenführung durch den Rheumatologen mit Bezug auf diagnostische, therapeutische als auch prognostische Aspekte werden in dieser Übersicht dargestellt. Obgleich es in der Behandlung keine spezifischen Empfehlungen für Sjögren-Patienten gibt, stellt das Management der Komplikationen bei dieser Erkrankung zweifelsohne erneut heraus, dass hier ein interdisziplinärer Zugang von herausragender Stellung vonnöten ist.
Spatial Fuzzy C-Means Algorithm for Bias Correction and Segmentation of Brain MRI Data

Accurate brain Magnetic Resonance Imaging (MRI) segmentation is a challenging task due to the complex anatomical structure of brain tissues in addition to the existence of intensity non-uniformity, partial volume effects, and noise. Segmentation methods based on fuzzy c-means approaches have been developed to overcome the uncertainty caused by these effects. In this study, a novel spatial modified bias correction FCM algorithm is applied to brain MRI for the purpose of segmentation where neighborhood effect is taken into consideration. The key contribution of this model is the use of the spatial information term to handle the potential sources of artifacts in the MRI data efficiently. Experiments performed on both simulated and real brain MRI datasets have shown that the proposed algorithm, called SBCFCM, has satisfactory outputs when compared with several state of the art algorithms.
Design of a broad-band low cross-polarized c-band antenna array for SAR applications

This paper presents a novel broad-band dual linearly polarized microstrip antenna array with low crosspolarization for operation in the frequency range from 5.05 GHz to 5.55 GHz used in the airborne E-SAR project. The main antenna array parameters are shown and discussed. The current development status is at the mounting of the first prototype of the antenna array. Therefore, experimental results of the array will be discussed during the paper presentation.
Bean yellow dwarf virus RepA, but not rep, binds to maize retinoblastoma protein, and the virus tolerates mutations in the consensus binding motif.

It has previously been reported that complementary-sense gene products of wheat dwarf virus (WDV), a geminivirus of the genus Mastrevirus that infects monocotyledonous plants, bind to human and maize retinoblastoma (Rb) protein. Rb proteins control cell-cycle progression by sequestering transcription factors required for entry into S-phase, suggesting that the virus modifies the cellular environment to produce conditions suitable for viral DNA replication. Using a yeast two-hybrid assay, we have investigated whether the complementary-sense gene products of bean yellow dwarf virus, a mastrevirus that is adapted to dicotyledonous plants, also bind maize Rb protein. We demonstrate that whereas RepA binds to Rb protein, Rep does not, suggesting that RepA alone regulates host gene expression and progression of cells to S-phase. RepA mutants containing L --> I, C --> S, C --> G, and E --> Q mutations within the consensus Rb protein binding motif LXCXE retained the ability to bind to Rb, but with reduced efficiency. Most notably, the E --> Q mutation reduced binding by approximately 95%. Nonetheless, all LXCXE mutants were able to replicate in tobacco protoplasts and to systemically infect Nicotiana benthamiana and bean, in which they produced wild-type symptoms.
Occupation-centred, occupation-based, occupation-focused: Same, same or different?

Abstract Background: Since the beginning of the occupational therapy profession, engagement in occupation has been valued as the primary therapeutic agent as well as the goal of intervention. While there are few today who would not support this idea, occupational therapists continue to struggle with implementing their beliefs through “what we do” and “how we do it”. Contributing to this problem is their failure to use terminology in a manner that clearly defines what and how occupational therapists do what they do in occupational therapy research, education, and practice. Methods: The author will, therefore, first discuss some key occupational therapy terms and propose that they represent an occupation-related taxonomy that can be used to more clearly define and describe for occupational therapists and others what they do and how they do what they do as occupational therapists. Then, with a goal of fostering critical self-reflection among occupational scientists and occupational therapy researchers, educators, and practitioners, the author will go through the stages of the occupational therapy process outlined in the Occupational Therapy Intervention Process Model (OTIPM) and demonstrate how a more precise use of this occupation-related taxonomy can facilitate maximizing the power of occupation in practice.
Lectures on Conversation

Volume 1: Fall 1964 - Spring 1965 Fall 1965 Spring 1966 Winter 1967 Spring 1967 Fall 1967 Spring 1968. Volume 2: Fall 1968 Winter 1969 Winter 1970 Spring 1970 Winter 1971 Spring 1971 Fall 1971 Spring 1972.
Effect of impact assembly on the fretting corrosion of modular hip tapers

The goal of this study was to determine the effect of assembly load and local assembly environmental conditions on the fretting corrosion of modular femoral stem tapers. Femoral head/taper assemblies in both similar (CoCrMo/CoCrMo) and mixed (CoCrMo/Ti‐6Al‐4V) alloy combinations were evaluated using an electrochemical test method. Specimens were assembled under impact loading and by hand, in both wet and dry conditions. Incremental cyclic loads ranging from 89 to 5,340 N were applied at a frequency of 3 Hz in Ringer's solution at ambient temperature. During the test, both the open circuit potential (OCP) and fretting current (ifret) were measured using a saturated calomel electrode (SCE) and counter electrode, respectively. The results were comparable for both mixed and similar alloy couples. Decreases in OCP and increases in ifret (indicators of oxide film fracture and repassivation) were seen with increasing load magnitude, often occurring at loads well below those expected clinically. OCP at the 5,340 N cyclic load ranged from −30.4 to −103.7 mV versus SCE for similar alloy couples, and −19.1 to −181.4 mV versus SCE for mixed alloy couples. Mean peak fretting currents ranged from 0.84 to 1.42 µA and 1.06 to 3.12 µA for similar and mixed alloy couples, respectively. The larger current magnitudes and more negative shifts in OCP for mixed alloy couples indicate the difference in oxide film fracture behavior between titanium and cobalt alloys. The load at which OCP began to drop (onset of fretting) was dependent upon the assembly conditions for both material couples. Specimens assembled with impact loads in air showed the highest resistance to fretting. The results of this study indicate that the assembly load and the environment both play a role in the initial stability of modular hip taper connections. © 2005 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res
Functional and Structural Characterization of Rhodopsin Oligomers*

A major question in G protein-coupled receptor signaling concerns the quaternary structure required for signal transduction. Do these transmembrane receptors function as monomers, dimers, or larger oligomers? We have investigated the oligomeric state of the model G protein-coupled receptor rhodopsin (Rho), which absorbs light and initiates a phototransduction-signaling cascade that forms the basis of vision. In this study, different forms of Rho were isolated using gel filtration techniques in mild detergents, including n-dodecyl-β-d-maltoside, n-tetradecyl-β-d-maltoside, and n-hexadecyl-β-d-maltoside. The quaternary structure of isolated Rho was determined by transmission electron microscopy, demonstrating that in micelles containing n-dodecyl-β-d-maltoside, Rho exists as a mixture of monomers and dimers whereas in n-tetradecyl-β-d-maltoside and n-hexadecyl-β-d-maltoside Rho forms higher ordered structures. Especially in n-hexadecyl-β-d-maltoside, most of the particles are present in tightly packed rows of dimers. The oligomerization of Rho seems to be important for interaction with its cognate G protein, transducin. Although the activated Rho (Meta II) monomer or dimers are capable of activating the G protein, transducin, the activation process is much faster when Rho exists as organized dimers. Our studies provide direct comparisons between signaling properties of Meta II in different quaternary complexes.
Acquired Hair Fragility in Pili anulati: Causal Relationship with Androgenetic Alopecia

Pili anulati are defined by characteristic alternating light and dark banding in the hair shaft, due to air-filled spaces between the macrofibrillar units of the hair cortex, and are regarded as a congenital hair shaft disorder without increased hair fragility. Two cases of pili anulati are presented, in which fragility of hair developed in a causal relationship with the onset of androgenetic alopecia. Accordingly, trichorrhexis-nodosa-like hair fracturing was exclusively limited to the androgenetic region. In general, secondary trichorrhexis nodosa is an unspecific finding related to excess stress of hair in relation to its fragility. With onset of hair thinning due to androgenetic alopecia, progressive reduction of hair shaft diameter may cause increased fragility in pili anulati. In this case, hair shaft fracturing occurs within the area of androgenetic alopecia and colocalizes with the air-filled cavities of pili anulati.