Miracle-dz/UniFAR-FTUs huggingface dataset:
Realizing XOR and XNOR Functions Using Tunnel Field-Effect Transistors

Recently, a few compact logic function realizations such as AND, OR, NAND and NOR have been proposed using double-gate tunnel field-effect transistor (DGTFET) with independent gate-control. In this article, using two-dimensional device simulations, we propose to realize the exclusive-OR (XOR) and exclusive-NOR (XNOR) logic functions. To implement an XOR function, a dual-material DGTFET (DM-DGTFET) is used. The structure is designed such that the band-to-band tunneling (BTBT) occurs at the boundary of these dual-material gates, rather than at the source–channel junction. Further, to realize the XNOR function, the gate–source and the gate–drain overlaps are used. The proposed DGTFET-based logic function implementations are able to modulate the current flow as per the required functionality, achieving an ON-state current by OFF-state current ( $I_{ON}/I_{OFF}$ ) ratio of order ~ 109. Furthermore, it is demonstrated that a CMOS-type XNOR gate can be realized by combining the proposed XNOR and XOR functions in the pull-up and pull-down network, respectively.
Comparative Genomic Analysis of Moderate Bacteriophages of Alfalfa Root Nodule Bacteria

The bacteriophage AP300 infecting Sinorhizobium meliloti was isolated from soil sample from mountainous region of Dagestan, which belongs to the Caucasus Center for Legume Variety under the grant RSF 17-16-01095. The AP300 genome was annotated and its similarity to bacteriophage vB MloP_Lo5R7ANS (NC_025431; Podoviridae family) infecting Mesorhizobium loti strains was revealed. It was found that insertion frequency of the Mesorhizobium phage vB MloP_Lo5R7ANS-like sequences in the chromosomes of S. meliloti strains was 6.591 • 10-4. In the chromosomes of 4 strains of Sinorhizobium meliloti isolated in geographically different regions from soils and nodules of alfalfa plants, intact vB MloP_Lo5R7ANS-like prophages were detected. The 46.39-57.14% ORFs of AP300 and 4 prophages were homologous to ORFs of vB MloP_Lo5R7ANS. The 18 ORFs from mentioned above ORFs were identified in all studied sequences and they were similar to those in vB MloP_Lo5R7ANS. The other 7.22-15.79% ORFs were homologous to other phages. ORFs encoding virion components: head, capsid, tail, virion, integrase were detected in soil bacteriophage AP300 and in all studied prophages determined in rhizobia symbionts of alfalfa. It was revealed that Sinorhizobium prophages could be phylogenetically related not only to Sinorhizobium phages, but also to phages of Mesorhizobium. Tail tubular protein A in all studied sequences has structural differences from the currently known TTPA Klebsiella phage KP32 (pdb5MU4), it has specific sites of post- translational modification, which can probably determine the specificity of interaction with EPS of nodule bacteria of alfalfa.
A decade and a half of protein intrinsic disorder: Biology still waits for physics

The abundant existence of proteins and regions that possess specific functions without being uniquely folded into unique 3D structures has become accepted by a significant number of protein scientists. Sequences of these intrinsically disordered proteins (IDPs) and IDP regions (IDPRs) are characterized by a number of specific features, such as low overall hydrophobicity and high net charge which makes these proteins predictable. IDPs/IDPRs possess large hydrodynamic volumes, low contents of ordered secondary structure, and are characterized by high structural heterogeneity. They are very flexible, but some may undergo disorder to order transitions in the presence of natural ligands. The degree of these structural rearrangements varies over a very wide range. IDPs/IDPRs are tightly controlled under the normal conditions and have numerous specific functions that complement functions of ordered proteins and domains. When lacking proper control, they have multiple roles in pathogenesis of various human diseases. Gaining structural and functional information about these proteins is a challenge, since they do not typically “freeze” while their “pictures are taken. ” However, despite or perhaps because of the experimental challenges, these fuzzy objects with fuzzy structures and fuzzy functions are among the most interesting targets for modern protein research. This review briefly summarizes some of the recent advances in this exciting field and considers some of the basic lessons learned from the analysis of physics, chemistry, and biology of IDPs.
A Hybrid Approach for DICOM Image Segmenta- tion Using Fuzzy Techniques

This paper provides an hybrid method for segmentation usingFCM thresholding with fuzzy levelset. FCM thresholding gives fine segmented results when compared to edge detection method. The optimization property of FCM is improved when it is combined with local thresholding. The application of Fuzzy levelset gives enhanced segmentation results.The experimental result proves that the hybrid method is efficient in statistical metrices that enhances the segmented results with fine regions .
Análisis matemático aplicado al diseño de sistemas de instrumentación electrónica para adquisición de señales en módulos robóticos

Este articulo describe el analisis matematico de la implementacion definitiva del diseno, simulacion y construccion de los sistemas de instrumentacion para la adquisicion de la senal. La matematica aplicada permite el diseno de algoritmos y procedimientos para modelar, representar, simplificar y evaluar los sistemas electronicos en aplicaciones industriales tales como la robotica, explorada en este proyecto. Este desarrollo matematico permite poner en practica los sistemas electronicos de adquisicion de datos del manipulador robotico, localizado en el laboratorio de investigacion de la Universidad Santo Tomas, que sera utilizado, mas adelante, en la realizacion de proyectos cientificos en el area electronica, como la robotica, control, comunicacion industrial e instrumentacion.
Multipurpose use and restoration of wetlands in semiarid Mediterranean catchments degraded by intensive agricultural use = Utilización multipropósito y restauración de humedales en cuencas mediterráneas semiáridas degradadas por el uso agrícola intensivo

El interes en restaurar humedales aumenta de forma constante en todo el mundo por las valiosas funciones y servicios que cumplen. Este trabajo pretende demostrar que es posible la utilizacion de humedales con multiples objetivos para la restauracion de zonas agricolas degradadas por riego agricola intensivo. Tambien pretende aportar una serie de directrices para el diseno y construccion de humedales de forma que queden integrados en el paisaje y sean funcionales a escala territorial. Para ello, se han estudiado humedales en la cuenca del rio Flumen (Monegros, Aragon, NE Espana) integrando cuatro perspectivas: el agua, el suelo, el paisaje y la biodiversidad. Se ha estudiado la capacidad de humedales existentes y construidos para mejorar la calidad del agua excedente de riego agricola, las caracteristicas del suelo en humedales banados con agua excedente de riego frente a la de campos agricolas, se han determinado el papel de los humedales en el paisaje mediante sistemas de informacion geografica y se ha estudiado la estructura y dinamica estacional de comunidades de aves presentes en ellos. La calidad del agua excedente del riego agricola mejora, se elimina la practica totalidad del nitrato, a su paso por los humedales cuando estos tienen el tamano adecuado. El paso continuo de agua reduce la salinidad del suelo en cuatro anos. La acumulacion de materia organica es lenta pero mejora la calidad de los suelos agricolas degradados. Una distribucion espacial dispersa y numerosa de humedales restaurados en una cuenca agricola favorece la mejora de la calidad del agua, la biodiversidad de aves y la recuperacion de suelos. La planificacion de proyectos de restauracion de humedales debe realizarse a escala de grandes cuencas, empezando a restaurar segun las necesidades de cuencas pequenas. Los humedales pueden cumplir varios objetivos simultaneamente siempre que se conozcan en profundidad las necesidades de cada objetivo y las limitaciones de la zona objeto de restauracion. Los resultados de este trabajo proporcionan herramientas para la integracion de los humedales con objetivos aislados o integrados diversos de mejora de la calidad del agua y suelo, la biodiversidad y el paisaje, en el desarrollo socio-economico de zonas semiaridas con intensa y extensa actividad agricola de regadio.
A role for fimbriae in Porphyromonas gingivalis invasion of oral epithelial cells

Isogenic mutants of Porphyromonas gingivalis which differ in the expression of fimbriae were used to examine the contribution of fimbriae in invasion of a human oral epithelial cell line (KB). At a multiplicity of infection of 100, the wild-type P. gingivalis strains 33277, 381, and A7436 exhibited adherence efficiencies of 5.5, 0.11, and 5.0%, respectively, and invasion efficiencies of 0.15, 0.03, and 0.10%, respectively. However, adherence to and invasion of KB cells was not detected with the P. gingivalis fimA mutants, DPG3 and MPG1. Adherence of P. gingivalis wild-type strains to KB cells was completely inhibited by the addition of hyperimmune sera raised to the major fimbriae. Examination by electron microscopy of invasion of epithelial cells by the P. gingivalis wild-type strain 381 revealed microvillus-like extensions around adherent bacteria; this was not observed with P. gingivalis fim mutants. Taken together, these results indicate that the P. gingivalis major fimbriae are required for adherence to and invasion of oral epithelial cells.
Royal jelly protects from taxol-induced testicular damages via improvement of antioxidant status and up-regulation of E2f1

Abstract This study was carried out to evaluate the protective effects of royal jelly (RJ) on taxol (TXL)-induced damage of the testis. Wistar rats were divided into control and test groups. The test group was divided into five subgroups; the first four groups along with TXL administration (7.5 mg/kg body weight (bw), weekly), received various doses of RJ (0, 50, 100, and 150 mg/kg bw). The last group received only RJ at 100 mg/kg. Royal jelly lowered the TXL-induced malondialdehyde and nitric oxide levels and enhanced the total thiol molecules in the testis. Remarkably RJ reduced the TXL-induced pathological injuries such as cellular shrinkage and seminiferous tubule depletion. Taxol-reduced sperm viability (27.5 ± 2.98 % vs. 85.0 ± 8.6% in the control group) was recovered by RJ administration as 80.5 ± 10.6% of the sperm were found alive in the group of animals which received 150 mg/kg RJ. The TXL-exposed and TXL plus RJ-administered animals showed a significant up-regulation of transcription factor E2f1 mRNA. Our data suggest that the TXL-induced histopathological and biochemical alterations could be protected by the administration of RJ. The RJ protective effects might be attributed to its antioxidant capacity and its capability in the regulation of E2f1 expression.
CSF Biomarkers for Alzheimer’s Disease: Levels of β-Amyloid, Tau, Phosphorylated Tau Relate to Clinical Symptoms and Survival

Cerebrospinal fluid (CSF) samples from 21 patients with a clinical diagnosis of Alzheimer’s disease (AD) participating in a 5-year treatment study with the choline esterase inhibitor tacrin were retrospectively analyzed for the contents of β-amyloid (Aβ42), total tau (T-tau) and phosphorylated tau (P-tau). A significant positive correlation between the level of P-tau and the number of symptoms according to the DSM-IV criteria (p = 0.041) and the NINCDS-ADRDA (p = 0.029) was observed (i.e. higher levels were found in cases with more symptoms). A significant positive correlation between T-tau, P-tau and ADAS-cog score was identified (i.e. higher levels were found with more severe cognitive dysfunction). Patients who died during the 5-year follow-up had significantly lower levels of Aβ42 (p = 0.011) than those who were still alive. Patients who had died in a 6-year follow-up had significantly lower levels of Aβ42 (p = 0.034) and higher levels of T-tau (p = 0.041) than patients still alive. Conclusion: CSF biomarkers do aid the clinical diagnosis of AD. Increased levels of P-tau and T-tau are possible markers for severity and abundance of symptoms in AD. Low levels of Aβ42 may indicate a higher risk of early death in AD.
Information and reformation in KM systems: big data and strategic decision-making

Purpose The purpose of this paper is to provide a theoretical framework of how knowledge management (KM) systems can facilitate the incorporation of big data into strategic decisions. Advanced analytics are becoming increasingly critical in making strategic decisions in any organization from the private to public sectors and from for-profit companies to not-for-profit organizations. Despite the growing importance of capturing, sharing and implementing people’s knowledge in organizations, it is still unclear how big data and the need for advanced analytics can inform and, if necessary, reform the design and implementation of KM systems. Design/methodology/approach To address this gap, a combined approach has been applied. The KM and data analysis systems implemented by companies were analyzed, and the analysis was complemented by a review of the extant literature. Findings Four types of data-based decisions and a set of ground rules are identified toward enabling KM systems to handle big data and advanced analytics. Practical implications The paper proposes a practical framework that takes into account the diverse combinations of data-based decisions. Suggestions are provided about how KM systems can be reformed to facilitate the incorporation of big data and advanced analytics into organizations’ strategic decision-making. Originality/value This is the first typology of data-based decision-making considering advanced analytics.
Beneficial effects of natural products on cells during ionizing radiation

Abstract Natural products like vegetables, fruits, and herbs are widely consumed by humans on a daily basis. These natural products have many biologic and pharmacologic properties. Ionizing radiation (IR) can interact with macromolecules like DNA, which induces serious side effects on cells and tissues. Natural products can directly scavenge free radicals produced by IR, and they can also activate or inhibit enzymes or proteins involved in the oxidative stress. Several natural products have dual biologic effects on normal and cancer cells during radiation and might be of interest for use in patients during radiotherapy. In this review, the effects of natural products on genotoxicity and cell death induced by IR were reviewed and some potentiated compounds were discussed.
A DC-Link Modulation Scheme With Phase-Shifted Current Control for Harmonic Cancellations in Multidrive Applications

This letter proposes a harmonic mitigation strategy to cancel out current harmonics induced by the front-end rectifiers in multidrive systems, which consist of diode rectifiers, silicon-controlled rectifiers (SCR), and boost converters in the dc-link. The proposed strategy is a combination of a new dc-link modulation scheme with a phase-shifted current control enabled by the SCR. The dc-link current modulation scheme is implemented by adding and subtracting specific modulation levels, which makes the total currents drawn from the grid “multilevel,” resulting in an improved current quality. Simulations and experiments have validated the effectiveness of the proposed harmonic mitigation solution for multidrive systems.
Experimental modeling and feedback control of a piezo-based milli-actuator

In magnetic disk drive actuators, requirements to record and read data at higher track densities has made mechanical resonances of the servo actuator, suspension and the head gimbal assembly a critial consideration. The application of piezo electric material in the servo actuator can be used to re ne and accomplish track following in (extremely) high track density magnetic data storage by controlling the mechanical resonance modes and serving as a so-called milli-actuator. In this paper the results on the modeling and control of a piezobased milli-actuator are presented. The modeling is done on the basis of a least squares curve tting of an estimated frequency response and taking into account uncertainties in the modeled resonance modes of the servo actuator. The design and implementation of a robust Author to whom all correspondence may be addressed, email: callafon@ucsd.edu Now with IBM Storage Systems Division, 5600 Cottle Rd., San Jose, CA 95193 Center for Magnetic Recording Research at UCSD
A study on the evolution model of the integration of informatization and industrialization

Integration of informatization and industrialization has been taken as an effective way of Chinese industrial transformation and upgrading, it is also the evitable choice to adjust the economic structure and the mode of economic development. Owing to the complexity of the integration of the two, we put forward the definition of the integration system. By analyzing the complexity and self-organization properties of the system, we discuss the mechanism of integration level, and further a dynamic model of integration level is used to describe the evolution of the system. According to the analysis of the model, the integration development progress of informatization and industrialization can be divided into four periods: initial period, growth period, popularizing period, mature period. The results offer enterprise quantitative analysis methods and scientific reference for integration of industrialization and informatization construction.
Antihypertensive drugs and the sympathetic nervous system.

The sympathetic nervous system (SNS) plays an important role in the regulation of blood pressure homeostasis and cardiac function. Furthermore, the increased SNS activity is a predictor of mortality in patients with hypertension, coronary artery disease and congestive heart failure. Experimental data and a few clinical trials suggest that there are important interactions between the main pressor systems, i.e. the SNS, the renin-angiotensin system and the vascular endothelium with the strongest vasoconstrictor, endothelin. The main methods for the assessment of SNS activity are described. Cardiovascular drugs of different classes interfere differently with the SNS and the other pressor systems. Pure vasodilators including nitrates, alpha-blockers and dihydropyridine (DHP)-calcium channel blockers increase SNS activity. Finally, central sympatholytics and possibly phenylalkylamine-type calcium channel blockers reduce SNS activity. The effects of angiotensin-II receptor antagonists on SNS activity in humans is not clear; experimental data are discussed in this review. There are important interactions between the pressor systems under experimental conditions. Recent studies in humans suggest that an activation of the SNS with pure vasodilators in parallel increases plasma endothelin. It can be assumed that, in cardiovascular diseases with already enhanced SNS activity, drugs which do not increase SNS activity or even lower it are preferable. Whether this reflects in lower mortality needs to be investigated in intervention trials.
Dual-Frequency O-Shaped 3-Way Bagley Power Divider Based on TLT

In this paper, dual-frequency O-shaped 3-way Bagley power divider is designed and analysed. Equal split power division is achieved at arbitrary design Frequencies. In this structure, two-section transmission line transformer is used to realize the dual-frequency operation. This paper describes a new Bagley power divider on a single-layer micro strip line that can reduce the occupied area. To validate the design procedure, O-shaped Bagley power divider is designed, simulated, and fabricated. The design frequencies are chosen to be 1 GHz and 2 GHz. Very good matching at the input port is achieved, and Good transmission parameters are obtained from these experiments. The results demonstrate that the design can fulfil our goals. Keyword -Bagley power divider (BPD), Microwave wireless application, Full wave simulator [IE3d], Ms Paint, Ms Excel, Transmission line transformer (TLT), Wilkinson power divider (WPD).
The "effective" gains and noise figures of individual components in an analog photonic link

This paper defines "effective" gains and noise figures for each component in an analog photonic link which, when inserted into the equation for the noise figure of cascaded components, yield the established link noise figure equation. Whereas the square-law electro-optic devices (modulator and photodetector) have effective gains that are - not surprisingly - dependent on RF power levels, it is found that the effective noise figures of the components that dominate the link noise figure are independent of RF power over the link's range of useful RF input power levels.
A recurrent fibrillin-1 mutation in severe early onset Marfan syndrome

Abstract The recurrent substitution of isoleucine for threonine at codon 1048 (I1048T) substitution has been linked to severe, early onset Marfan syndrome, however, the existence of strong genotype-phenotype associations in Marfan syndrome (MFS) is not widely agreed upon. Our aim is to substantiate the association between the I1048T substitution and a severe clinical presentation to facilitate care planning and genetic counseling. We review the clinical findings from seven cases of early-onset MFS with a recurrent I1048T substitution. The presented findings include those from one newly diagnosed case, significant new detail from three additional cases, and a review of published findings in three cases. All seven individuals with the I1048T substitution had mitral insufficiency, arachnodactyly and characteristic facies consistent with early-onset MFS. Our findings support the existence of a genotype-phenotype correlation between the I1048T substitution and early-onset MFS. Recognition of this relationship has implications for genetic counseling and clinical care. Additionally, exploration of how the I1048T substitution results in a severe phenotype may lead to further insight into the pathophysiology of MFS.
Oscillations corticales et intelligibilité de la parole dégradée (Oscillatory cortical activity and intelligibility of degraded speech) [in French]

Many neurocognitive aspects associated with the processing of speech were up to now studied by the analysis of event-related potentials. However, none of these cortical responses can be considered as a direct indicator of successful lexical access during speech comprehension. The aim of the present study is to develop an experimental paradigm and a statistical analysis on electrophysiological data, in order to identify timefrequency patterns in the oscillatory cortical activity that correlate with the intelligibility of degraded speech. For this purpose we used noise-vocoded speech that is very difficult to understand without prior exposure. Noise-vocoded words were presented before and after a short period of perceptual learning, and we compared the oscillatory activity following stimuli rated as “intelligible” or “unintelligible” by participants (N=12). Results show that we were able to identify three oscillatory activities with specific topology and latency resulting from a successful lexical access. MOTS-CLES : Intelligibilite, Noise-vocoded speech, EEG, Oscillations corticales