Miracle-dz/UniFAR-FTUs huggingface dataset:
Endovascular treatment of a complex broad neck bifurcation aneurysm at peripheral center by pconus stent: A new neck bridging device

Endovascular treatment of wide-necked aneurysms is a challenge in itself, especially, if branches are incorporated in the neck or base of the aneurysm. The problem is greater if the availability of technical resources and expertise is limited. Difficult endovascular treatment options in such cases include the use of double balloon remodeling and bilateral intracranial stents with associated higher complication rates. However, with availability of a new neck bridging device, treatment of such aneurysms is becoming relatively easy. We present a case of the ruptured basilar top aneurysm with incorporated bilateral posterior cerebral artery origins treated with pCONus stent-assisted coiling. We intend to draw the attention of neurointerventionists to newly available neck bridging device which has lower thrombogenicity than stents, require a shorter learning curve, are compatible with routine delivery catheters, can be deployed quickly and can be performed even on a single plane digital subtraction angiography equipment with minimal expertise.
Analysis and Cancellation of Mixed-Numerologies Interference for Massive MIMO-OFDM UL

The extremely diverse service requirements is an important challenge for the future generations of wireless communication technologies. As promising solutions, orthogonal frequency division multiplexing (OFDM)-based massive multiple-input multiple-output (MIMO) and mixed numerologies transmission are proposed. This letter investigates the transmission of different users, sharing the same bandwidth while they are associated to different numerologies. A transceiver design which aims to manage the mixed numerology spectrum sharing (SS) transmission is first presented. Then, we analyze the inter-numerology interference (INI) and derive its corresponding theoretical expressions. Based on the derived closed-form expressions, a new INI cancellation scheme is introduced, which efficiently mitigates the INI and enhances the performance of massive MIMO-OFDM uplink systems.
Effect of obesity on inflammatory markers and renal functions

Aim: To examine the relationship between inflammation criteria and body mass index in otherwise‐healthy obese schoolchildren and to evaluate the effect of obesity on renal functions. Methods: Sixty‐five otherwise‐healthy obese children (median age 10.8 y, range 7.1–16.5 y; median body mass index 26.8 kg/m2, range 19.9–38.7 kg/m2) and 20 healthy controls (median age 12.4 y, range 10.1–17.1 y; median body mass index 18.8 kg/m2, range 17.3–23.1 kg/m2) were included. Blood and urine samples were taken from every child. Results: Children in the obese and control groups had similar age and sex distributions (p>0.05). Inflammatory mediators were higher in obese children (p<0.05). A significant positive correlation was found between glomerular filtration rate and body mass index in the whole study group (r=0.39, p=0.001). A positive correlation was found between body mass index standard deviation and inflammatory mediators and glomerular filtration rate. No significant difference existed regarding protein and microalbumin excretion in the urine.
Hydrophobic calcium carbonate with hierarchical micro–/nanostructure for improving foaming capacity

In this paper, a strategy for synthesizing hierarchical calcite calcium carbonate (CaCO3) microspheres was developed. The material was characterized by SEM, TEM, EDS, FT-IR and XRD. The synthetic CaCO3 has an excellent micro-/nano self-assembled structure, which changes the surface wettability. And the contact angle of CaCO3 with water as high as 130.9°, which has a great change compared with the ordinary CaCO3. At the same time, the product has good foaming properties (increase by 17%) and high adhesion. Novelly, the topographical hydrophobic particles are applied to stabilize the foam.
Brand Pride in Consumer–Brand Relationships: Towards a Conceptual Framework

Brands are rapidly moving away from the traditional transactional approach to a relational journey with their users. In most cases, Consumer- Brand Relationships are based on the extent of congruence between individuals and their favourite brands. This paper aims to contribute to this journey and understand the genesis and outcomes of such a relationship wherein the consumer feels “proud” to be associated with his/her brand. Specifically the purpose of the paper is to understand the antecedents and consequences of a less explored construct, Brand Pride. This conceptual paper is based on an extensive and detailed review of literature pertaining to the areas of emotional branding, consumer-brand relationships, pride in brand associations, self-congruence and behavioral outcomes. It also evaluates the impact of a narssistic personality on such relationships. The authors propose a conceptual framework for Brand Pride which would lead to a deeper understanding in the phenomenology of Brand Pride and its subsequent impact on higher order Consumer-Brand Relationships. Crystallization of this concept would lead to invaluable insights in the advancement in emotional branding both for academicians and practitioners, with Brand Pride being the emotion in focus.
KetaDex 12.5/25 Nasal Spray: A New Sedative-Analgesic Formulation

Intranasal administration offers an alternative route for systemically acting drugs, especially low molecular weight, lipophilic and potent drugs with high first-pass metabolism. It’s well recognized that nasal bioavailability is optimum with atomized volumes less than 100 microlitres (0.1 ml), available ampoule content therefore has limited nasal residence time, absorption and bioavailability due to excess volume that drains into the throat and is swallowed. Ketadex nasal spray offers additive effects of sedation, analgesia, bronchodilation with nasal decongestion and dilation of cutaneous veins for cannulation. Opposing side effects produce dry mouth, reduced secretions and cardiovascular stability. A wide margin of safety is predicted because both ketamine and dexmedetomidine are devoid of respiratory depressant effects. We present an easy to administer nasal spray, concentrated (3.75x) ketamine and dexmedetomidine solution to produce reliable sedation and analgesia with minimal adverse effects due to favourable pharmacokinetic and pharmacodynamic interactions.
Charakterystyka tłuszczów zwierzęcych i aspekty zdrowotne związane z ich spożywaniem

Mięso, nawet najbardziej chude, zawiera pewne ilości tłuszczu. Jakość oraz ilość tłuszczu są ważnymi częściami składowymi ogólnie pojmowanej jakości mięsa. W zależności od miejsca występowania tłuszczu w mięsie można go podzielić na tłuszcz pozawłókienkowy i śródwłókienkowy. Tłuszcz pozawłókienkowy zlokalizowany jest w tkance łącznej – w jej elementach komórkowych przekształconych w komórki tłuszczowe, natomiast tłuszcz śródwłókienkowy występuje wewnątrz włókien mięśniowych [12]. Dr hab. Krzysztof DASIEWICZ Dr inż. Marta CHMIEL Zakład Technologii Mięsa, Katedra Technologii Żywności Szkoła Główna Gospodarstwa Wiejskiego w Warszawie
Effect of Slot-Pole Combination on the Electromagnetic Performance of Ironless Stator AFPM Machine With Concentrated Windings

Due to the elimination of the magnetic core on the stator, the design of coils is more flexible and more sensitive to the number of rotor poles for ironless stator axial flux permanent magnet (AFPM) machine. The slot-pole combination is a vital aspect of optimization design for the improvement of torque and power density. This article is mainly aimed at investigating the influence of slot-pole combination on the comprehensive performance of ironless stator AFPM machine with non-overlapping concentrated windings. Firstly, the space utilization of coils and winding factor of non-overlapping concentrated winding are deduced in formula form to compare the output capacity. And the copper mass and utilization are analyzed with different numbers of slots and stator diameter. Then, field utilization ratio is defined and derived to analyze magnetic flux leakage of Halbach-array PM dual-rotor for different numbers of poles. The performance comparison of the optimized prototypes is carried out using three-dimensional finite element analysis (3-D FEA). The back-EMF, torque and winding loss are also highlighted. Finally, a 50 kW prototype with 12-slot and 10-pole is designed and manufactured for experimental validations. This paper provides a valuable reference to select the basic configuration for the ironless stator AFPM machine application.
PENTINGNYA TECHNOLOGICAL PEDAGOGICAL CONTENT KNOWLEDGE (TPACK) GURU DI ERA REVOLUSI INDUSTRI 4.0

Era revolusi industry generasi ke-4 atau yang disebut sebagai revolusi industry 4.0 mengarahkan semua bidang kehidupan pada teknologi digital, artificial intelegence , big data , dan robotic . Tak terkecuali bidang pendidikan, memasuki revolusi industry 4.0 dunia pendidikan dituntut untuk mengkonstruksi pembelajaran yang melibatkan teknologi. Pendidikan 4.0 merupakan istilah yang digunakan oleh para ahli pendidikan untuk menggambarkan cara mengimplementasikan teknologi cyber ke dalam pembelajaran. Pendidikan 4.0 menuntut guru menguasai teknologi untuk diintegrasikan dalam proses pembelajaran. Kemampuan guru dalam menguasai teknologi dalam pembelajaran dapat dilihat melalui TPaCK (Technological Pedagogical Content Knowledge) yang dimiliki guru. TPaCK merupakan kerangka teoritis untuk mengintegrasikan teknologi, pedagogik, dan materi pelajaran dalam pembelajaran. Artikel ini mengkaji tentang tiga unsur pengetahuan TPaCK dan interaksi diantara setiap unsur TPacK serta kaitannya dengan revolusi industri 4.0.
Understanding family physical activity and health related behaviours : a multi-layered approach

In spite of the growing awareness of the importance and health enhancing benefits of physical activity (Anderson et al., 2000; Barengo et at., 2004; Kaleta et al., 2006) the population still remain predominantly inactive (Haskell et at., 2007). Limited UK published data (to date) has simultaneously examined children and families health and physical activity patterns (Wing, 2000). The research aimed to explore and better understand the determinants associated with children and families health related behaviour and physical activity patterns and investigate the underlining factors which direct current and guide future health related behaviour choices. Prior to Study 1 an extensive needs assessment of the area (gathering data on the children and families literacy levels and understanding of research) was undertaken to assist in the development of Study 1's measures. Study 1 then utilised a parental (Goding, 1985; Baker et al., 1994) and children's (Baldings, 1997) health related behaviour questionnaire to explore the habitual physical and nutritional behaviours of children and their families in Knowsley (UK) thus creating a baseline of data to investigate further. One hundred and fifteen children (n=115; M=55, F=60) mean age of 8.6 years completed the self-report questionnaire from five Knowsley MBC (UK) primary schools. Fifty-seven parents (n=57; F=54, M =3) completed and returned the postal self-report questionnaire. Statistical analysis was carried out using SPSS for windows Version 7 and descriptive statistics (cross tabulation with two dimensional tables), frequency distributions and Chi Square used to assess the children and parents' nominal health related behaviour results.
Role of serum albumin and BMI in elective major abdominal surgeries

This study was conducted on 60 patients who underwent major elective abdominal surgery at JSSH, Mysore between October 2013 to September 2015. Sr. albumin and BMI were estimated preoperatively and postoperative complications were noted. Statistical analysis was done accordingly, p value < 0.05 was considered statistically significant. Ztest and Fischer exact ttest were used for analysis. Increased post-operative morbidity is seen in patients with Sr. albumin < 3.0g/dl. There is no mortality in our study. There was no significant correlation between BMI and postoperative outcome in these patients.
Pengaruh Implementasi Sistem Akuntansi Instansi Basis Akrual (SAIBA) terhadap Kepuasan dan Kinerja Pengguna

Penelitian ini bertujuan untuk menganalisis pengaruh penerapan aplikasi SAIBA terhadap kepuasan pengguna dan kinerja pengguna berdasarkan perspektif modifikasi Model Delone dan McLean. Penelitian ini menggunakan enam variabel (kualitas sistem, kualitas informasi, kualitas layanan, kualitas pendidikan dan pelatihan, kepuasan pengguna dan kinerja pengguna). Penelitian ini menggunakan kuesioner. Responden adalah semua operator SAIBA di instansi atau satuan kerja mitra KPPN Semarang I dan II dengan menggunakan purposive sampling sebagai teknik pengambilan sampel. Data yang diperoleh dianalisis dengan menggunakan aplikasi IBM SPSS 22 dan WarpPLS 6.0. Hasil penelitian menunjukkan kualitas sistem, kualitas informasi, kualitas layanan, dan variabel kualitas pendidikan dan pelatihan memiliki pengaruh positif pada kepuasan pengguna dan kinerja pengguna.
The Effect of Primary Care Visits on Health Care Utilization: Findings from a Randomized Controlled Trial

We conducted a randomized controlled trial, enrolling low-income uninsured adults in Virginia (United States), to determine whether cash incentives are effective at encouraging a primary care provider (PCP) visit, and at lowering utilization and costs. Subjects were randomized to four groups: untreated controls, and one of three incentive arms with incentives of $0, $25, or $50 for visiting a PCP within six months of group assignment. We used the exogenous variation generated by the experiment to obtain causal evidence on the effects of a PCP visit. We observed modest reductions in non-urgent emergency department use and increased outpatient use, but no reductions in overall costs. These findings in utilization are consistent with the expectation that PCPs offer an alternative to the emergency department for non-emergent conditions. Total costs did not decline because any savings from avoiding the emergency department were offset by increased outpatient utilization.
Prognostic significance and therapeutic implications of PTEN, EGFR and MAPK/ERK in cervical squamous cell carcinoma

Introduction: There is a considerable need for cervical cancer treatments. The epidermal growth factor receptor (EGFR) and its pathway molecules affect cervical squamous cell carcinoma (CSCC) regarding its prognosis and anti-cancer therapy. Aims of study: To investigate the biologic expression of EGFR and the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway mediators in CSCCs, through investigating immunohistochemical expressions of EGFR, extracellular signalregulated kinases (ERK 1/2) and phosphatase and tensin homolog (PTEN), in a trial to assess their prognostic and survival outcome. Patients and methods: Immunohistochemical analysis (IHC) was performed for 35 cervical squamous cell carcinoma specimens to detect 3 target antigens EGFR, PTEN, and MAPK/ERK1/2. Results: EGFR and MAPK/ERK1/2 staining showed a significant association with each of the following clinical parameters- increased patient age, high tumor stage, grade and positive lymph nodes. They are also associated with relapse and poor patient survival. PTEN showed a significant association with decreased age, small tumor size, low grade, low stage and negative lymph nodes, meaning a good prognostic clinical outcome with less relapse. Conclusion: Cervical cancer patients with PTEN expression had good prognosis in contrary to those with EGFR and ERK expressions that had poor prognosis. Treatment directions of CSCC might be of great benefits in the form of improved clinical outcome with EGFR pathway targeted therapy.
Results of structural analysis of medical appointments of queretetin drugs and its derivatives in Ukraine

The aim: to analyze the structure of medical prescriptions for quercetin and its derivatives in UkraineMaterials and methods. We used data from an expert survey of doctors from 25 cities of Ukraine, which was conducted during 2017-2018. The survey involved doctors of various specialties who had «very high» (k ≥ 0.91), «high» (k = 0.71-0.90) and «satisfactory» (k = 0.51-0.70) level of competence. This indicator was determined using five coefficients (k1+n), which characterized the level of theoretical and applied training of specialists in the organization of the medical and diagnostic process for patients suffering from various types of angiopathies. We used the historical, analytical, comparative, systemic, logical, hypothetical-deductive, mathematical and statistical methods, as well as the expert survey method.Results. It was found that the largest number of appointments (51.82%) was made by therapists/family doctors, and the smallest - by endocrinologists (3.6%). The vast majority of respondents (except for allergologists and endocrinologists) prescribed these drugs in treatment according to the main diagnosis of the patient. At the same time, only therapists/family doctors and cardiologists prescribed quercetin and its derivatives in a wide range of development of the clinical picture of the pathology, namely the main diagnosis, with its complications and associated diseases. Doctors of all specialties, except for otolaryngologists noted the use of quercetin and its derivatives in the treatment of concomitant pathologies of sick patients. The first position in the structure of medical appointments (1st level of ICD-10) was taken by appointments in the treatment of I-diseases of the circulatory system (78.97%), the second – by J-diseases of the respiratory system (11.30%), and the third – K-digestive system diseases (6.04%). In the structure of prescriptions for patients with cardiovascular pathologies, the largest share was made in the treatment of angina pectoris (49.60%), in the second position – chronic ischemic heart disease (21.61%), and in the third – other cerebrovascular diseases (10.60%). Conclusions. It was proved that the highest prescribing rates of quercetin and its derivatives were carried out by therapists/family doctors in the treatment of diseases of the cardiovascular system according to the main diagnosis, its complications and associated pathologies. The low level or lack of prescription of drugs of this group in doctors of other specialties requires further research in the indicated direction
The Effect of Hidden Quality Cost on Supply Chain Management of Sales and Market Share

There have been difficulties in managing costs effectively which have led to reduction in both market and sales share. This study aimed to find remedies to the challenge of determining and measuring the hidden quality costs due to its negative effect on the customer satisfaction. This study engaged in the measurement and calculation of hidden quality costs in a sound and scientific manner in order to find solutions to the problem and achieve the research objectives. Increase in the sales and profits and market share of the economic unit and satisfaction of the customer are achieved through the effective the management of these costs. A deductive approach was employed in the study and a number of conclusions were made from the analysis of the results. First, the study conclude that lack of information as provided by the total quality costs is experienced due to failure to calculate the hidden quality costs. As the hidden quality costs provide indicators, they must be applied as required. Also, there is a task related to the risks surrounding the economic growth when it comes to the risk of losing market share. Similarly, the research found that these costs and disclosure, which affects the management of these costs effectively and objectively, are not measured and calculated by many of the industrial companies in Iraq.
The two zinc fingers in the nucleocapsid domain of the HIV-1 Gag precursor are equivalent for the interaction with the genomic RNA in the cytoplasm, but not for the recruitment of the complexes at the plasma membrane

The HIV-1 Gag precursor specifically selects the unspliced viral genomic RNA (gRNA) from the bulk of cellular and spliced viral RNAs via its nucleocapsid (NC) domain and drives gRNA encapsidation at the plasma membrane (PM). To further identify the determinants governing the intracellular trafficking of Gag-gRNA complexes and their accumulation at the PM, we compared, in living and fixed cells, the interactions between gRNA and wild-type (WT) Gag or Gag mutants carrying deletions in NC zinc fingers (ZFs), or a non-myristoylated version of Gag. Our data showed that the deletion of both ZFs simultaneously or the complete NC domain completely abolished intracytoplasmic Gag-gRNA interactions. Deletion of either ZF delayed the delivery of gRNA to the PM but did not prevent Gag-gRNA interactions in the cytoplasm, indicating that the two ZFs display redundant roles in this respect. However, ZF2 played a more prominent role than ZF1 in the accumulation of the ribonucleoprotein complexes at the PM. Finally, the myristate group which is mandatory for anchoring the complexes at the MP, was found to be dispensable for the association of Gag with the gRNA in the cytosol. STATEMENT of SIGNIFICANCE Formation of HIV-1 retroviral particles relies on specific interactions between the retroviral Gag precursor and the unspliced genomic RNA (gRNA). During the late phase of replication, Gag orchestrates the assembly of newly formed viruses at the plasma membrane (PM). It has been shown that the intracellular HIV-1 gRNA recognition is governed by the two-zinc finger (ZF) motifs of the nucleocapsid (NC) domain in Gag. Here we provided a clear picture of the role of ZFs in the cellular trafficking of Gag-gRNA complexes to the PM by showing that either ZF was sufficient to efficiently promote these interactions in the cytoplasm, while interestingly, ZF2 played a more prominent role in the relocation of these ribonucleoprotein complexes at the PM assembly sites.
Chief physicians’ perceived need for improvement of morbidity and mortality conferences: the role of structural and procedural characteristics

Background Mortality and morbidity conferences (M&MCs) are used to retrospectively discuss adverse events. Recently, the focus of the M&MC shifted from a clinical learning tool to a forum for analysing events using systems-based approaches. The aim of this study was to explore the M&MC characteristics that are associated with perceived improvement needs reported by chief physicians. Methods A cross-sectional survey among chief physicians assessed characteristics of currently implemented M&MCs in Switzerland (44 items). A summative score was developed covering information on procedural and structural characteristics commonly recommended for design of M&MCs. Results Of 223 participants, 145 (65%) indicated that their M&MC could be improved. Regression analysis revealed that the score (ie, the sum of structural and procedural features of the M&MC) was associated with self-perceived need for improvement of M&MCs (OR=0.73, CI 0.62 to 0.85, P<0.001). Chief physicians who explicitly select cases for M&MC discussion which involve problems in cooperation had twice the odds of reporting a need for improvement (OR=1.99, CI 1.05 to 3.74, P=0.034). Conclusion Our study provides important insights into the factors contributing to chief physicians’ evaluation of M&MCs. Offering support for addressing the procedural and structural features of the M&MCs may be a good lever to improve them.