Miracle-dz/UniFAR-FTUs huggingface dataset:
Marine Monitoring & Early Warning Detection using Wireless Sensor Networks: Challenges

Marine monitoring using wireless sensor networks (WSN) is a challenging area of research due to the instability of the oceanic environment. The early warning system for ocean monitoring and defending is an instant need of the hour constraint for avoiding huge losses in marine world. It can be possible using the information gathering technologies, such as ultrasonic, radar, machine vision, infrared, laser, and other integrated technologies, such as wireless sensor networks, underwater marine detectors and computer information processing. It sound like science fiction, but the fact in today’s technology is to know about the complexity in ocean monitoring, managing and protecting the marine safety. This paper mainly focuses on the applications of WSNs and early detection measures of marine Traffic Control Technology using WSNs involved to protect oceanic marine world.
Modelling the eukaryotic cell cycle

The cell division cycle is a biological mechanism that ensures the production of new cells by mitosis. This process is cyclic, begins with a growth factor (GF) and progresses by the sequential activation of cyclin and cyclindependent kinases (cdk). In this thesis, we propose a new model for the eukaryotic cell cycle. The model gives a more complete description than previous reported models. It considers that all cyclin-cdk complexes participating in the cell cycle can describe the global mechanism in a minimal way. We simulate the time evolution concentration of the complexes cyclinD-cdk4-6, cyclinE-cdk2, cyclinA-cdk1-2, cyclinB-cdk1, transcription factor E2F and of the GF in a network of enzymatic reactions. Some of these enzymatic reactions have positive feedback loops. Positive feedback loops provided periodic solutions for both cyclinE-cdk2 and cyclinB-cdk1 complexes. CyclinD-cdk4-6 and cyclinA-cdk1-2 don’t have positive feedback loops and don’t oscillate, unless by external oscillation of GF which can induce a global cyclin-cdk oscillation. A Cell cycle checkpoint arises by the phosphatase cdc25. This protein participates in positive feedback loops and induces the system to cross a Hopf bifurcation, leading to stable oscillations of cyclinE-cdk2 and cyclinB-cdk1, corresponding to the G1/S and G2/M transitions, respectively. Globally, the differential equation model obtained with the mass-action law, sets the growth factor as the master regulator of the cell cycle and connects important extracellular and intracellular components for the generation of the eukaryotic cell cycle. Index Terms Cell cycle, Growth Factor (GF), cyclins, cyclin-dependent kinase (Cdk), systems biology.
Relation between the constant rank and the relaxed constant rank constraint qualifications

This paper discusses a relation between the constant rank constraint qualification (CRCQ) and the recently proposed relaxed constant rank constraint qualification (RCRCQ). We show that a parametric constraint system satisfying the RCRCQ is locally diffeomorphic to a system satisfying the CRCQ. We use this result to extend some existing results for the CRCQ to the RCRCQ, establish a relation between the RCRCQ and the Mangasarian-Fromovitz constraint qualification, and obtain a weakened version of the Aubin property under the RCRCQ.
Pancreatic cancer: a review of clinical diagnosis, epidemiology, treatment and outcomes

This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites.
Determination of Gluten Level on Traditionally Treated Wheat

The scope of the present study was to determine the gluten level, thousand kernel weight, pH, and titrable acidity, on traditionally treated wheat. The results depicts that increased pH, titrable acidity, significantly decreased thousand kernel weight reduced the gluten level in 24 hr sprouting (20.08 g). In 12hr soaking (37.4 g) and 12 hr sprouting (36.48 g) treatment gluten level increases when compared with raw wheat gluten (27.52 g), where parboiled, fried, soaked + parboiled wheat has no gluten network ball get isolated. In conclusion study point out that germination increased the gluten level and prolonged increases in sprouting time reduced the gluten protein.
Well being of Secondary and Higher Secondary school Teachers

The education of children and young people is at the core of teachers’ work. Student success, enthusiasm, and commitment of teachers. It is well known that teachers are the most important in contributing to student success, satisfaction and achievement. Employee wellbeing is an important factor in quality, performance and productivity. In the current educational environment, where schools are trying to increase student ability with a diminishing budget, teacher wellbeing may be overlooked as a ‘nice to have’ rather than as essential. Secondary and Higher Secondary school teachers are builder of the nation like a farmer cultivating crops from seeds. Wellbeing refers to the subjective feeling of happiness in respect to ones physical, psychological, social and cultural experiences. Wellbeing is the essential condition that helps Secondary and Higher Secondary school teachers to direct their effect towards fulfilment of national goal. There is a reason to believe that all teachers do not have adequate feeling of wellbeing. There for this study surveyed the level of subjective wellbeing of 121 Secondary and Higher Secondary school teachers (both male and female) employed in govt aided schools in Kolkata using GWBS.
Modelling Visitor Flow from the Visitor Perspective: The Psychology of Landscape Navigation

This paper reviews basic issues underlying the monitoring and modeling of the movements of visitors in large-scale natural parks and recreation areas. Modeling of "visitor flow" is related to research and methods in associated fields, including environmental preference, environmental values/attitudes and wayfinding. Relevant psychophysiological and neurological research and theory is also reviewed to reveal the fundamental basis of dissociations between verbal reports and actions. It is argued that traditional verbal survey methods cannot in principle provide an adequate basis for models of human landscape navigation. The need for “visitor management” at the world’s major natural parks and protected areas is obvious to everyone. Certainly those charged with the management of such areas recognize that the “human dimension” is at once the most potent and the most problematic of the forces with which they must contend. The physical and biological forces of wind, fire, flood, insects and drought can be overwhelming and catastrophic, but natural systems have evolved in the context of just such disturbances, and generally adapt to them rather well. The onslaught of increasing multitudes of adoring human tourists, recreationists and seasonal residents, while perhaps not as dramatic as a hurricane or a flood, has proven much more relentless. Natural systems have not had the millennia required to evolve suitable adaptive responses to this very recent and sometimes erratic
Quality of life of people living with HIV/AIDS attending antiretroviral clinic in the center of excellence in HIV care in India

INTRODUCTION: HIV/AIDS is a serious challenge globally. A plethora of morbidities due to crippling immune system reduces quality of life (QOL). The advent of highly active antiretroviral treatment has changed this deadly disease to a chronic manageable illness with focus shifting from fighting virus to ensuring a good QOL. OBJECTIVE: To assess the QOL among people living with HIV/AIDS (PLHA) and factors influencing, if any in Indian setting. MATERIALS AND METHODS: An institutional-based cross-sectional study was carried out among 220 PLHA (male >15 years) attending Anti-Retroviral Therapy Centre of the center of excellence in HIV care in India (Calcutta School of Tropical Medicine, Kolkata) from May 2012 to April 2013. QOL was assessed using WHO-QOL-BREF questionnaire from January 2013 to December 2013. Statistical analysis was done using SPSS version 16; multivariate logistic regression was computed with adjusted odds ratio in 95% confidence interval; P < 0.05 was considered statistically significant. RESULTS: In this study, all 220 PLHA men participated (response rate 96.5%) where more than half (55.5%) participants rated their QOL as neither poor nor good; only 28.2% replied good. One-third (38.6%) were dissatisfied while only one-fifth (19.1%) satisfied and 41.4% mentioned neither satisfied nor dissatisfied with their health. Mean score ± standard deviation on various domains and facets of WHOQOL-BREF were physical health score 56.2 ± 9.8, psychological health 63.1 ± 8.7, social relationship 48.9 ± 14.8, and environmental health 51.3 ± 13.7. CONCLUSION: PLHA had good QOL on psychological, physical, and environmental domain that reflects better services provided at Calcutta School of Tropical Medicine (CSTM), Kolkata, but they scored poorly in social relationship domain, which may be suggestive of ineffective social services network. This study concludes that increase existing social and emotional support with innovation should be implemented to improve their QOL.
Activation of the Unfolded Protein Response Pathway in Cytotoxic T Cells: A Comparison Between in vitro Stimulation, Infection, and the Tumor Microenvironment

IRE1α is an extremely conserved intracellular receptor that regulates one branch of the unfolded protein response (UPR). Homologs of IRE1α are found virtually throughout all eukaryotes. This receptor plays a pivotal role in a cell’s reaction to stress, determining whether to take compensatory measures and survive or undergo apoptosis and die. While the role of the unfolded protein response in lower organisms and secretory cells has been comprehensively studied, the precise role of IRE1α in the context of cytotoxic T cells has only begun to be elucidated within the past decade. This review discusses what is known about IRE1α and the unfolded protein response in cytotoxic T cells within the context of development, pathogen response, and cancer cell growth.
Awareness of cancer cervix and its prevention among students in Melaka, Malaysia

BACKGROUND: Cancer cervix is caused by human papillomavirus (HPV), oncogenic virus and has vaccines and screening as its preventive measures. This study analyzes the change in awareness and attitudes of nonmedical students toward the condition following the use of an educational module. METHODOLOGY: The study design was quasi-experimental. The interprofessional (IP) team implemented an educational module and analyzed the difference in awareness of young individuals toward the cancer cervix. A pretest and posttest written questionnaire, customized for both genders, was administered with the intervention of the educational module in between. The module consisted of a short educational presentation along with a group activity. A follow-up survey was also done after 2 months to check the attrition of awareness. The statistical analysis was done using MacNemar test using SPSS 12 IBM software and significance of differences were determined. RESULTS: There was a significant improvement of knowledge and awareness on linkage between HPV and cervical cancer (P < 0.001). There was also significant change with regard to attitudes toward cervical cancer vaccination (P = 0.004). The knowledge of HPV linkage to the malignancy was maintained after 2 months of gap. The subjects also wished for more future awareness program. CONCLUSIONS: There is improved awareness in the dental and foundation in science students, and this improved awareness will ensure favorable attitudes toward cervical cancer vaccines or will attend regular screening programs. Awareness program must be held at regular intervals at different locations to enhance the knowledge dissemination of this common yet preventable genital malignancy of females. The IP collaboration and practices will help in reducing the disease burden of the society in future.
Synthesis of Calix-Salen Silver Corates for Evaluation of Their Antimicrobial and Anticancer Activities

Silver-based products are becoming popular as antimicrobial agents because of the failure of antibiotics available for tackling the drug-resistant microbial strains. As silver is well tolerated by normal human cells, silver complexes have emerged as important antineoplastic agents. Further, if silver ions are encapsulated within an organic molecule—an azacorand—it may serve as a better substitute for cisplatin or other metal complexes. The calix-salen-type corates were synthesized using silver ions as the template. 5,5′-methylene-bis-salicylaldehyde was reacted with ethylene diamine in methanol at room temperature in the presence of silver nitrate. The resultant corand trapped the silver template in their cavity. The electron-withdrawing and electron-releasing groups like −NO2, −Br, −C(CH3)3, and −OCH3 were substituted on the bis-aldehyde to study their effects on the antimicrobial and anticancer activities of silver corates. The silver corates were found to have better antimicrobial activity than some of the standard drugs. Bromo-substituted corate-3, nitro-substituted corate-4, and tert-butyl-substituted corate-5 were found to be potent antibacterial agents among all. The bromo-substituted corate-3 was found to be the most potent fungicidal agent among all silver corates. The result of antineoplastic activity suggests that unsubstituted corate-1 and bromo-substituted corate-3 are potential candidates to be used as therapeutic molecules for cancer treatment, which requires further validation.
Noninvasive Imaging and Correlative Histology of Cone Photoreceptor Structure in the Pig Retina

Purpose To evaluate different methods of studying cone photoreceptor structure in wild-type (WT) and transgenic pigs carrying the human rhodopsin P23H mutant gene (TgP23H). Methods For in vivo imaging, pigs were anesthetized with tiletamine-zolazepam and isoflurane and given lidocaine-bupivacaine retrobulbar injections. Stay sutures and a custom head mount were used to hold and steer the head for adaptive optics scanning light ophthalmoscopy (AOSLO). Six WT and TgP23H littermates were imaged at postnatal day 30 (P30), P90, and P180 with AOSLO and optical coherence tomography (OCT), and two additional sets of littermates were imaged at P3 and P15 with OCT only. AOSLO imaging and correlative differential interference contrast microscopy were performed on a P240 WT pig and on WT and TgP23H littermates at P30 and P180. Results AOSLO cone density generally underestimates histology density (mean difference ± SD = 24.8% ± 21.4%). The intensity of the outer retinal hyperreflective OCT band attributed to photoreceptors is attenuated in TgP23H pigs at all ages. In contrast, AOSLO images show cones that retain inner and outer segments through P180. At retinal locations outside the visual streak, TgP23H pigs show a heterogeneous degenerating cone mosaic by using two criteria: variable contrast on a split detector AOSLO and high reflectivity on a confocal AOSLO. Conclusions AOSLO reveals that the cone mosaic is similar to ex vivo histology. Its use as a noninvasive tool will enable observation of morphologic changes that arise in the cone mosaic of TgP23H pigs over time. Translational Relevance Pigs are widely used for translational studies, and the ability to noninvasively assess cellular changes in the cone mosaic will facilitate more detailed investigations of new retinal disease models as well as outcomes of potential therapies.
Comparison of attachment styles of addicted parents and non-addicted parents in health-care referents

BACKGROUND: Growing interest in issues of attachment, sociocultural, psychological, and above all clinical perspectives is also reflected in the emergence of research on “attachment style and parental parenting style in referrals to addiction treatment centers. ” METHODS: This was a cross-sectional study. Three health centers were selected randomly from among the health centers of Neyshabur city in 2015–2016 year. The sampling was done so that all individuals who had the characteristics of the research unit and had the consent to participate in the study were justified by the researcher and completed questionnaire form. We used Chi-square, one-way analysis of variance, Mann–Whitney, and Kruskal–Wallis tests. RESULTS: In the present study, safe attachment scores in children with healthy parents were significantly more than children with addicted parents. CONCLUSION: Addiction has an important role in reducing attachment to children, and because this decrease in attachment has dangerous consequences in child's life.
Temperature and moisture dependence of daily growth of Scots pine (Pinus sylvestris L.) roots in Southern Finland

Abstract Scots pine (Pinus sylvestris L.) is one of the most important conifers in Northern Europe. In boreal forests, over one-third of net primary production is allocated to roots. Pioneer roots expand the horizontal and vertical root systems and transport nutrients and water from belowground to aboveground. Fibrous roots, often colonized by mycorrhiza, emerge from the pioneer roots and absorb water and nutrients from the soil. In this study, we installed three flatbed scanners to detect the daily growth of both pioneer and fibrous roots of Scots pine during the growing season of 2018, a year with an unexpected summer drought in Southern Finland. The growth rate of both types of roots had a positive relationship with temperature. However, the relations between root elongation rate and soil moisture differed significantly between scanners and between root types indicating spatial heterogeneity in soil moisture. The pioneer roots were more tolerant to severe environmental conditions than the fibrous roots. The pioneer roots initiated elongation earlier and ceased it later than the fibrous roots. Elongation ended when the temperature dropped below the threshold temperature of 4 °C for pioneer roots and 6 °C for fibrous roots. During the summer drought, the fibrous roots halted root surface area growth at the beginning of the drought, but there was no drought effect on the pioneer roots over the same period. To compare the timing of root production and the aboveground organs’ production, we used the CASSIA model, which estimates the aboveground tree carbon dynamics. In this study, root growth started and ceased later than growth of aboveground organs. Pioneer roots accounted for 87% of total root productivity. We suggest that future carbon allocation models should separate the roots by root types (pioneer and fibrous), as their growth patterns are different and they have different reactions to changes in the soil environment.
Potential of Matrix Metalloproteinase Inhibitors for the Treatment of Local Tissue Damage Induced by a Type P-I Snake Venom Metalloproteinase

Snake bite envenoming is a public health problem that was recently included in the list of neglected tropical diseases of the World Health Organization. In the search of new therapies for the treatment of local tissue damage induced by snake venom metalloproteinases (SVMPs), we tested the inhibitory activity of peptidomimetic compounds designed as inhibitors of matrix metalloproteinases on the activities of the SVMP Batx-I, from Bothrops atrox venom. The evaluated compounds show great potential for the inhibition of Batx-I proteolytic, hemorrhagic and edema-forming activities, especially the compound CP471474, a peptidomimetic including a hydroxamate zinc binding group. Molecular dynamics simulations suggest that binding of this compound to the enzyme is mediated by the electrostatic interaction between the hydroxamate group and the zinc cofactor, as well as contacts, mainly hydrophobic, between the side chain of the compound and amino acids located in the substrate binding subsites S1 and S1′. These results show that CP471474 constitutes a promising compound for the development of co-adjuvants to neutralize local tissue damage induced by snake venom metalloproteinases.
Surface-Enhanced Absorption Spectroscopy for Optical Fiber Sensing

Visible and near-infrared spectroscopy are widely used for sensing applications but suffer from poor signal-to-noise ratios for the detection of compounds with low concentrations. Enhancement by surface plasmon resonance is a popular technique that can be utilized to increase the signal of absorption spectroscopy due to the increased near-field created close to the plasmons. Despite interest in surface-enhanced infrared absorption spectroscopy (SEIRAS), the method is usually applied in lab setups rather than real-life sensing situations. This study aimed to achieve enhanced absorption from plasmons on a fiber-optic probe and thus move closer to applications of SEIRAS. A tapered coreless fiber coated with a 100 nm Au film supported signal enhancement at visible wavelengths. An increase in absorption was shown for two dyes spanning concentrations from 5 × 10−8 mol/L to 8 × 10−4 mol/L: Rhodamine 6G and Crystal Violet. In the presence of the Au film, the absorbance signal was 2–3 times higher than from an identically tapered uncoated fiber. The results confirm that the concept of SEIRAS can be implemented on an optical fiber probe, enabling enhanced signal detection in remote sensing applications.