Miracle-dz/UniFAR-FTUs huggingface dataset:
A Survey of Augmented, Virtual, and Mixed Reality for Cultural Heritage

A multimedia approach to the diffusion, communication, and exploitation of Cultural Heritage (CH) is a well-established trend worldwide. Several studies demonstrate that the use of new and combined media enhances how culture is experienced. The benefit is in terms of both number of people who can have access to knowledge and the quality of the diffusion of the knowledge itself. In this regard, CH uses augmented-, virtual-, and mixed-reality technologies for different purposes, including education, exhibition enhancement, exploration, reconstruction, and virtual museums. These technologies enable user-centred presentation and make cultural heritage digitally accessible, especially when physical access is constrained. A number of surveys of these emerging technologies have been conducted; however, they are either not domain specific or lack a holistic perspective in that they do not cover all the aspects of the technology. A review of these technologies from a cultural heritage perspective is therefore warranted. Accordingly, our article surveys the state-of-the-art in augmented-, virtual-, and mixed-reality systems as a whole and from a cultural heritage perspective. In addition, we identify specific application areas in digital cultural heritage and make suggestions as to which technology is most appropriate in each case. Finally, the article predicts future research directions for augmented and virtual reality, with a particular focus on interaction interfaces and explores the implications for the cultural heritage domain.
New generation pharmacotherapy in elderly multiple myeloma patients

Background: Observational databases have demonstrated that the overall prognosis of multiple myeloma patients has markedly improved over the past decade, yet the greatest strides have been attained in younger rather than older patients. Objective: To review recent clinical trials that include new generation agents (thalidomide, lenalidomide and bortezomib) and autologous stem cell transplantation in older multiple myeloma patients. Results: Conventional regimens such as melphalan plus prednisone can be improved with the addition of thalidomide or bortezomib: more patients attain complete and near-complete remission, and progression-free survival rates are nearly doubled. In addition, autologous hematopoietic stem cell transplantation studies show that this treatment approach can be used successfully in selected older myeloma patients in whom the toxicity profile of autotransplant and resulting overall survival may be similar to that obtained in the younger patient group. Conclusions: In the advanced-age population, implementation of new therapies results in significant benefits in older as well as younger patients.
Bronchoscopic or blind sampling techniques for the diagnosis of ventilator-associated pneumonia.

The purpose of this prospective postmortem study was to assess the diagnostic accuracy of bronchoscopic techniques (bronchoalveolar lavage [BAL] and protected specimen brush [PSB]) and nonbronchoscopic techniques (blind bronchial sampling [BBS] and mini-BAL) in the diagnosis of ventilator-associated pneumonia (VAP). The results of each technique were compared with histology and culture of lung tissue specimens obtained by surgical pneumonectomies in 38 patients who died after at least 72 h of mechanical ventilation. Histology was positive for VAP in 18 patients and negative in 20 patients. There were 12 definite VAP (positive histology and positive lung cultures) and 6 histologic VAP (positive histology and negative cultures). Clinical pulmonary infection score (CPIS) at a threshold of 6 achieved a sensitivity of 72% and a specificity of 85%. When the CPIS was combined with the logarithmic concentration of the predominant microorganism obtained from the BBS sample culture, specificity was increased to 95%.
The influence of female literacy on the sex ratio in Indian states

Background: Son preference has resulted in a lopsided sex ratio in India. There is also an interregional variation in the sex ratios among the states. Aims & Objectives: This study is conducted to evaluate the influence of female literacy on sex ratios through three decades from 1981 to 2011. Materials and Methods: Data from the past four censuses were analyzed to determine the decadal change in female literacy and sex ratios in 24 states and the results were utilized to determine the impact of improving female literacy on the sex ratio in the states. Results: Female literacy in India improved from 29.85% in 1981 to 65.45 in 2011. In the same period the sex ratio improved from 934 to 943. The change in sex ratio and female literacy rates in individual states however is not uniform and there is significant regional variation. Conclusion: Female literacy has a positive bearing on the sex ratio and states which have a higher literacy rate show faster movement towards gender parity. Therefore higher the female literacy rate in a state more is the improvement in sex ratio for every percent further rise in female literacy.
High-Resolution Episcopic Microscopy Data-Based Measurements of the Arteries of Mouse Embryos: Evaluation of Significance and Reproducibility under Routine Conditions

Defining the role of genes in the genesis of congenital cardiovascular defects involves comparisons of the diameters of arteries measured in wild-type and genetically engineered mouse embryos. This study aims at evaluating the significance and reproducibility of measurements of the diameters of the great intrathoracic arteries of mouse embryos, as produced under routine conditions, by employing a recently suggested measuring method. Using high-resolution episcopic microscopy, we generated digital volume data of 60 mouse embryos (voxel size 1.07 × 1.07 × 2 µm3) of developmental stage 23 according to Theiler. We randomly split the 60 data sets into two groups of 30 and assigned each group to a diploma student. In addition, an experienced scientist received 12 randomly selected specimens of each group. Independently, the researchers created three-dimensional models of the intrathoracic arteries and identified comparable measurement positions along the ascending aorta, pulmonary trunk and descending aorta. At each position, they defined virtual resections cutting through the volume data perpendicular to the longitudinal axis of the artery. In the virtual resections, the researchers measured the perimeter of the lumen of the artery. The diameter was calculated from the perimeter. Then, we performed statistic comparisons of the diameters measured in micrometres and of the ratio of each measured diameter and the diameter of the ascending aorta. Comparisons of the ratios did not reveal statistically significant differences between the measurements created by the different scientists. We assume that the used measuring protocol is highly robust and produces reproducible and significant results under routine conditions.
The 10 ‘R’s of safe multidisciplinary drug administration

Nurses are responsible for medication administration, and, as with many other nursing interventions, some risk is involved. If an error occurs, a patient may suffer harm or injury, which may lead to a permanent disability or a fatality. To ensure safe drug administration, nurses are encouraged to follow the five rights (‘R’s; patient, drug, route, time and dose) of medication administration to prevent errors in administration. The five ‘R’s do not consider all causes of drug errors; instead, they focus on medication administration at the bedside so they relate only to this stage of a drug prescription. A drug’s journey is more than what happens at the bedside; therefore, the reduction of errors requires more than just the five ‘R’s. This article proposes a multi-professional, evidence-based approach to medicines management, which all clinicians can work towards, together. Clinicians can achieve this approach by considering the National Patients Safety Agency’s definition of a medication error and the values set out by the National Prescribing Centre. The approach utilizes 10 ‘R’s, which provide a benchmark for good practice. The 10 ‘Rs’ advocate the need for the knowledge of the causes of drug errors, how to implement strategies to reduce drug errors, how to ensure safe practice throughout the medication journey, from chemical preparation, to monitoring outcomes, to response.
Improving medication management of depression in health plans.

OBJECTIVE Improving depression treatment is critical given low rates of appropriate care. Health plan performance measures that address quality of antidepressant medication management, specifically, have been stagnating at relatively low levels. Identifying health plan characteristics associated with better performance could contribute to quality improvement for this aspect of depression treatment. METHODS Data for 2003 were linked from two sources: a nationally representative survey of 368 health plans about their behavioral health services and the National Committee for Quality Assurance's Health Plan Employer Data and Information Set (HEDIS) antidepressant medication management (AMM) scores, which reflect the percentage of eligible members whose care met specified criteria. The analytic sample present in both data sets totaled 361 products offered by 183 plans. Plan characteristics were grouped into organizational, provider, and consumer domains. Bivariate tests and regression analyses were conducted to estimate the relationship between these characteristics and health plan performance on three AMM measures: effective acute-phase treatment, effective continuation-phase treatment, and optimal practitioner contact. RESULTS Mean HEDIS AMM scores were 60% for effective acute-phase treatment, 43% for continuation-phase treatment, and 22% for optimal practitioner contact. Individual feedback to clinicians about their performance, lower cost sharing for outpatient mental health, and greater access to selective serotonin reuptake inhibitors were significantly associated with better plan performance in terms of antidepressant medication management. CONCLUSIONS Health plan characteristics were significantly associated with the quality of one important aspect of depression care, antidepressant medication management. Many of the factors that were identified suggest actionable ways for plans to improve quality of depression care.
Análise da função respiratória na doença de Parkinson

We studied 40 parkinsonian patients (P), mean age 50-80 years, with Hoehn and Yahr stages I-III and 40 no parkinsonian patients (NP), with similar characteristics. The results of the thoracic amplitude was 1,8+/-0,8cm of P that showed a reduction to 4,3+/-1,0 cm of NP (p=0,00001), the vital capacity and forced vital capacity, 66,8+/-20,3% and 69,6+/-22,2% of P was decreased that 82,3+/-15,7% and 82,7+/-16,6% of NP (p=0,00001 and p=0,0023). There was not difference among the maximal inspiratory and expiratory mouth pressures, 33,5+/-12,7 cmH2O and 36,3+/-17,8 cmH2O of P and 37,0+/-12,2 cmH2O and 43,1+/-16,6 cmH2O of NP (p=0,1753 and p=0,0398), the forced expiratory volume in 1 second, 71,3+/-25,6% of P and 80,6+/-23,6% of NP (p=0,0899), and the forced expiratory volume in 1 second/ forced vital capacity, 104,5+/-19,9% of P and 97,4+/-22,8% of NP (p=0,1234). The parkinsonian patients present restrictive pulmonary dysfunction, low chest wall compliance and the respiratory muscle strength do not decreased.
Strain in African American and White American Caregivers of Hospitalized Elderly

This study investigated the relationship between race and strain in family caregivers of hospitalized older patients. Data came from a sample of 176 African American and 194 White American caregivers who were identified as part of a prospective study of changes in functional status of older hospitalized patients. When interaction terms were added to a multivariate model assessing the relationship between race and strain, race lost its significant influence on strain. Instead, its combination with two other variables-being an adult child caregiver and being married-emerged as important correlates. Being an adult child had deleterious consequences for White caregivers, whereas being married had advantageous consequences for African American caregivers. Findings emphasize the need to reevaluate how the race variable is used in future research and the need for hospital staff to be sensitive to racial diversity when working with families to plan for older patients' discharge.
L-Carnitine Treatment in Patients with Mild Diastolic Heart Failure Is Associated with Improvement in Diastolic Function and Symptoms

Objectives:L-Carnitine is a crucial component of activated fatty acid transport. The aim of this study was to evaluate the effect of L-carnitine on patients with a history of mild heart failure and diastolic dysfunction. Methods: Twenty-nine patients with a history of NYHA functional class II symptoms and ejection fraction >45% with documented grade 1 diastolic dysfunction on echocardiogram were randomized in blinded fashion to receive 1,500 mg of L-carnitine daily for 3 months in comparison to a no treatment group (31 patients). Baseline echocardiographic and follow-up measurements of diastolic parameters were assessed after 3 months. Results: Important parameters of diastolic function improved in the L-carnitine group only: left atrial size (3.6 ± 0.4 cm before treatment vs. 3.4 ± 0.5 cm after treatment, p = 0.01); isovolemic relaxation time (127 ± 26 ms before vs. 113 ± 24 ms after treatment, p = 0.007); septal mitral E′ velocity (0.064 ± 0.01 m/s before vs. 0.074 ± 0.01 m/s after treatment, p = 0.01), and lateral mitral E velocity (0.082 ± 0.01 m/s before vs. 0.091 ± 0.02 m/s after treatment, p = 0.006). Dyspnea also significantly improved in L-carnitine-treated patients. Conclusion: In patients with a history of diastolic heart failure, important indices of diastolic function and symptoms appear to improve with L-carnitine treatment.
Sistema de vigilancia de rotavirus en hospitales centinelas en Chile

OBJECTIVE: diarrheas are one of the main causes of morbidity and mortality worldwide. In Chile, diarrhea surveillance is a priority, particularly those caused by rotavitus, in order to find out their epidemiology including circulating serotypes and to promptly detect possible outbreaks. METHODS: a surveillance system was implemented in 8 pediatric hospitals considered as sentinel sites because they cover 62 % of the under 5 years-old population from Metropolitana, Valparaiso and Bio-Bio regions. The standardized case definitions of the World Health Organization were used. The sample analysis was based on ELISA method in the Public Health Institute laboratories. The surveillance system is based on an online electronic form supported on PHP platform, 5.2. 6 version, designed to create dynamic and accessible webpages through passwords from the sentinel center terminals of the Regional Ministerial Department of Health and the Public Health Institute; the variables are weekly and monthly introduced. The statistical analysis is carried out through Epinfo-2000. RESULTS: five hundred and ninety nine fecal samples were analyzed in eight months; 164 of them were positive to rotavirus (27.4 %) for a rate of 0.2 per 1000 pop. Fifty six percent were males whereas under 2 years-old group was the most affected (69 %). CONCLUSIONS: the implementation of the sentinel rotavirus surveillance system is a useful tool for the analysis of this disease behavior and for decision-making in the health national programs.
Front-line treatment of Philadelphia positive chronic myeloid leukemia with imatinib and interferon-α: 5-year outcome

This study confirms the excellent response to imatinib front-line therapy in patients with chronic myeloid leukemia. By contrast, most patients discontinued pegylated interferon-α due to its side effects. In 2004, we reported the short-term results of a multicentric, phase 2 study of imatinib 400 mg daily and pegylated interferon-α in the treatment of 76 early chronic phase Philadelphia-positive chronic myeloid leukemia patients. In this report, we update the results with an observation time of five years. After two years of treatment, all but 10 patients (13%) had discontinued pegylated interferon-α. The complete cytogenetic response rate at five years was 87%, and 94% of complete cytogenetic responders maintained the complete cytogenetic response after five years. All but one complete cytogenetic response also achieved a major molecular response. These data confirm the excellent response to imatinib front-line and the stability of the complete cytogenetic response. Any possible additional benefit of the combination with interferon-α remains uncertain, due to low patient compliance.
Pathology of liver transplantation: an update

Abstract This article will concentrate on two main areas of liver allograft pathology where there have been significant advances during the past few years. The first is rejection, which continues to be a common cause of graft dysfunction in the early postoperative period and a rare cause of graft failure. Histological assessment remains essential to confirm the diagnosis of rejection. A recently developed, internationally accepted schema (the Banff schema) for grading acute rejection and staging chronic rejection will be described. With increasing numbers of people surviving long-term following transplantation, the issue of disease recurrence is becoming increasingly important. The second part of the paper deals with the histological diagnosis of disease recurrence and the assessment of other changes seen in biopsies obtained more than 12 months following liver transplantation.
Healthcare Concerns of Parents of Individuals With Fragile X Syndrome Preliminary Results From Qualitative Data Analyses

Background. Medical problems of individuals with intellectual disabilities (ID) have been increasingly recognized in recent years. However, less attention has been give to the needs of individuals in different diagnostic groups. The purpose of this study was to explore the healthcare experiences of parents of children with fragile X syndrome in Ontario. The main objectives of the study were (1) to identify the challenges and successes parents face when accessing healthcare services for their children with ID; and (2) to identify suggestions and strategies to enhance access and quality of healthcare services for children with ID. Methods. Qualitative data were obtained from parents during a focus group conducted with five mothers, two fathers and one foster mother of children with fragile X syndrome.
Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia

Purpose: RG7112 is a small-molecule MDM2 antagonist. MDM2 is a negative regulator of the tumor suppressor p53 and frequently overexpressed in leukemias. Thus, a phase I study of RG7112 in patients with hematologic malignancies was conducted. Experimental Design: Primary study objectives included determination of the dose and safety profile of RG7112. Secondary objectives included evaluation of pharmacokinetics; pharmacodynamics, such as TP53-mutation status and MDM2 expression; and preliminary clinical activity. Patients were divided into two cohorts: Stratum A [relapsed/refractory acute myeloid leukemia (AML; except acute promyelocytic leukemia), acute lymphoblastic leukemia, and chronic myelogenous leukemia] and Stratum B (relapsed/refractory chronic lymphocytic leukemia/small cell lymphocytic leukemia; CLL/sCLL). Some Stratum A patients were treated at the MTD to assess clinical activity. Results: RG7112 was administered to 116 patients (96 patients in Stratum A and 20 patients in Stratum B). All patients experienced at least 1 adverse event, and 3 dose-limiting toxicities were reported. Pharmacokinetic analysis indicated that twice-daily dosing enhanced daily exposure. Antileukemia activity was observed in the 30 patients with AML assessed at the MTD, including 5 patients who met International Working Group (IWG) criteria for response. Exploratory analysis revealed TP53 mutations in 14% of Stratum A patients and in 40% of Stratum B patients. Two patients with TP53 mutations exhibited clinical activity. p53 target genes were induced only in TP53 wild-type leukemic cells. Baseline expression levels of MDM2 correlated positively with clinical response. Conclusions: RG7112 demonstrated clinical activity against relapsed/refractory AML and CLL/sCLL. MDM2 inhibition resulted in p53 stabilization and transcriptional activation of p53-target genes. We provide proof-of-concept that MDM2 inhibition restores p53 function and generates clinical responses in hematologic malignancies. Clin Cancer Res; 22(4); 868–76. ©2015 AACR.
Evaluation of the clinical performance of a chlorhexidine gluconate antimicrobial transparent dressing

Each year, an estimated 250,000 cases of central line associated bloodstream infections occur in hospitals in the United States (CDC, 2005). Reduction of CRBSI has become a major focus for education and initiatives to improve practice. Various antimicrobial agents and practices are supported with evidence to demonstrate impact on CRBSI. The broad spectrum activity of chlorhexidine as an antibacterial, antiviral, and antifungal agent is well accepted (Denton, 2001). The purpose of this clinical evaluation was to statistically validate the performance of a new chlorhexidine gluconate (CHG) gel dressing. A fully integrated transparent dressing with a CHG gel pad was evaluated in six different facilities across the United States over a period of 73 days with 64 different clinicians. A total of 500 CHG gel dressings were applied during the evaluation period. The clinicians were asked to evaluate 16 levels of performance criteria of the new CHG gel dressings and compare these areas of performance to the performance of their current CHG disk plus transparent dressing being used at their facility. Their current dressing was replaced with the new CHG gel dressing. All sites changed dressings at 24—48 hours as needed, and then at seven days. The evaluation questions were striated into four performance groups: ease of application, gel dressing performance, securement function and ‘other’. In all 16 levels of performance ratings, the CHG gel dressing was rated ‘same as’, ‘better’, or ‘much better’. In addition to the antimicrobial advantages of a CHG gel dressing, clinical data demonstrates the following benefits: ease of use of a one piece CHG gel dressing, ability to fully visualise the insertion site through the gel, and absorption of fluid under the dressing. The new CHG gel dressing was well tolerated by patients and performed in a manner that equalled or well exceeded the current two step process of antimicrobial dressing application.
Osteoporose bei Krebserkrankungen

Zusammenfassung Patienten mit Krebserkrankungen haben ein deutlich erhöhtes Risiko für eine Osteoporose. Epidemiologische Daten hierzu sind vor allem für Deutschland recht knapp. Grund der Osteoporose ist neben direkten knochentoxischen Effekten von Tumorzytokinen und Chemotherapeutika meist ein therapieinduzierter Hypogonadismus, weshalb vorwiegend Patienten mit Mamma- und Prostatakarzinom betroffen sind. Bei anderen Tumorarten spielen unter anderem steroidhaltige Behandlungsregimes eine ätiologische Rolle. Therapeutisch kommen neben Basismaßnahmen wie einer „knochengesunden Lebensweise“ und der Gabe von Kalzium und Vitamin D vor allem Bisphosphonate zum Einsatz. Auch für den monoklonalen Antikörper Denosumab, einen RANKL-Inhibitor, liegen erste positive Ergebnisse vor.