Miracle-dz/UniFAR-FTUs huggingface dataset:
Discrete Sequential Information Coding: Heteroclinic Cognitive Dynamics

Discrete sequential information coding is a key mechanism that transforms complex cognitive brain activity into a low-dimensional dynamical process based on the sequential switching among finite numbers of patterns. The storage size of the corresponding process is large because of the permutation capacity as a function of control signals in ensembles of these patterns. Extracting low-dimensional functional dynamics from multiple large-scale neural populations is a central problem both in neuro- and cognitive- sciences. Experimental results in the last decade represent a solid base for the creation of low-dimensional models of different cognitive functions and allow moving toward a dynamical theory of consciousness. We discuss here a methodology to build simple kinetic equations that can be the mathematical skeleton of this theory. Models of the corresponding discrete information processing can be designed using the following dynamical principles: (i) clusterization of the neural activity in space and time and formation of information patterns; (ii) robustness of the sequential dynamics based on heteroclinic chains of metastable clusters; and (iii) sensitivity of such sequential dynamics to intrinsic and external informational signals. We analyze sequential discrete coding based on winnerless competition low-frequency dynamics. Under such dynamics, entrainment, and heteroclinic coordination leads to a large variety of coding regimes that are invariant in time.
Maternal control of seed weight in rapeseed (Brassica napus L.): the causal link between the size of pod (mother, source) and seed (offspring, sink)

Summary Seed size/weight is one of the key traits related to plant domestication and crop improvement. In rapeseed (Brassica napus L.) germplasm, seed weight shows extensive variation, but its regulatory mechanism is poorly understood. To identify the key mechanism of seed weight regulation, a systematic comparative study was performed. Genetic, morphological and cytological evidence showed that seed weight was controlled by maternal genotype, through the regulation of seed size mainly via cell number. The physiological evidence indicated that differences in the pod length might result in differences in pod wall photosynthetic area, carbohydrates and the final seed weight. We also identified two pleiotropic major quantitative trait loci that acted indirectly on seed weight via their effects on pod length. RNA‐seq results showed that genes related to pod development and hormones were significantly differentially expressed in the pod wall; genes related to development, cell division, nutrient reservoir and ribosomal proteins were all up‐regulated in the seeds of the large‐seed pool. Finally, we proposed a potential seed weight regulatory mechanism that is specific to rapeseed and novel in plants. The results demonstrate a causal link between the size of the pod (mother, source) and the seed (offspring, sink) in rapeseed, which provides novel insight into the maternal control of seed weight and will open a new research field in plants.
A Pollen Diet Confers Ultraviolet-B Resistance in Phytoseiid Mites by Providing Antioxidants

Many plant-dwelling mites including phytophagous spider mites and predacious phytoseiid mites suffer lethal deleterious effects from solar ultraviolet-B (UVB; 280–315 nm wavelength) radiation. Phytoseiid species also often feed on pollen as an alternative food source. As pollen is frequently exposed to solar radiation, it is likely to contain compounds that protect germ cells from UVB radiation and radiant heat. If phytoseiid mites can obtain these protective compounds, pollen feeding may play a role in their adaptation to UVB. In this study, we compared the potential protective effects of tea pollen, peach pollen, and Tetranychus urticae mites as food items in Neoseiulus californicus. Egg hatchability and adult female survival after UVB irradiation were higher in pollen-fed than mite-fed N. californicus. The major protective effects of peach pollen and tea pollen were UVB shielding effects and antioxidant capacity, respectively, and these were derived from distinctive antioxidant components. The major antioxidant in peach pollen was tri-p-coumaroylspermidine, although its antioxidant capacity was relatively low; instead, it effectively absorbed UVB radiation. By contrast, the major antioxidants of tea pollen were catechin and epicatechin 3-gallate, which had high antioxidant capacities. Our results indicate that the protective antioxidant components in pollen improved UVB resistance in N. californicus, contributing to their adaptation to solar radiation.
Direct measurements of two-way wave-particle energy transfer in a collisionless space plasma

Two-step energy transfer in space plasma Plasmas are ionized gases that contain negative electrons, positive ions, and electromagnetic fields. These constituents can oscillate in position over time, carrying energy as plasma waves. In principle, such waves could transfer energy between two different ion populations. Kitamura et al. analyzed data from the Magnetospheric Multiscale mission, a group of four spacecraft that are flying in tight formation through Earth's magnetosphere. They discovered an event in which energy was transferred from hydrogen ions to plasma waves and then from the waves to helium ions. This energy transfer process is likely to occur in many other plasma environments. Science, this issue p. 1000 Energy transfer between H+ ions, plasma waves, and He+ ions is observed in a space plasma. Particle acceleration by plasma waves and spontaneous wave generation are fundamental energy and momentum exchange processes in collisionless plasmas. Such wave-particle interactions occur ubiquitously in space. We present ultrafast measurements in Earth’s magnetosphere by the Magnetospheric Multiscale spacecraft that enabled quantitative evaluation of energy transfer in interactions associated with electromagnetic ion cyclotron waves. The observed ion distributions are not symmetric around the magnetic field direction but are in phase with the plasma wave fields. The wave-ion phase relations demonstrate that a cyclotron resonance transferred energy from hot protons to waves, which in turn nonresonantly accelerated cold He+ to energies up to ~2 kilo–electron volts. These observations provide direct quantitative evidence for collisionless energy transfer in plasmas between distinct particle populations via wave-particle interactions.
Robust Signaling for Bursty Interference

This paper studies a bursty interference channel, where the presence/absence of interference is modeled by a block-i.i. d. Bernoulli process that stays constant for a duration of T symbols (referred to as coherence block) and then changes independently to a new state. We consider both a quasi-static setup, where the interference state remains constant during the whole transmission of the codeword, and an ergodic setup, where a codeword spans several coherence blocks. For the quasi-static setup, we study the largest rate of a coding strategy that provides reliable communication at a basic rate and allows an increased (opportunistic) rate when there is no interference. For the ergodic setup, we study the largest achievable rate. We study how non-causal knowledge of the interference state, referred to as channel-state information (CSI), affects the achievable rates. We derive converse and achievability bounds for (i) local CSI at the receiver side only; (ii) local CSI at the transmitter and receiver side; and (iii) global CSI at all nodes. Our bounds allow us to identify when interference burstiness is beneficial and in which scenarios global CSI outperforms local CSI. The joint treatment of the quasi-static and ergodic setup further allows for a thorough comparison of these two setups.
Subjective social status and neural processing of race in Mexican American adolescents

Abstract Adolescence is a sensitive period for sociocultural development in which facets of social identity, including social status and race, become especially salient. Despite the heightened importance of both social status and race during this developmental period, no known work has examined how individual differences in social status influence perceptions of race in adolescents. Thus, in the present study, we investigated how both subjective social status and objective socioeconomic status (SES) influence neural responses to race. Twenty-three Mexican American adolescents (15 females; mean age = 17.22 years) were scanned using functional magnetic resonance imaging while they viewed Black and White faces in a standard labeling task. Adolescents rated their subjective social status in US society, while their parents responded to questions about their educational background, occupation, and economic strain (objective SES). Results demonstrated a negative association between subjective social status and neural responses in the amygdala, fusiform face area, and medial prefrontal cortex when adolescents viewed Black (relative to White) faces. In other words, adolescents with lower subjective social status showed greater activity in neural regions involved in processing salience, perceptual expertise, and thinking about the minds of others when they viewed images of Black faces, suggesting enhanced salience of race for these youth. There was no relationship between objective SES and neural responses to the faces. Moreover, instructing participants to focus on the gender or emotion expression on the face attenuated the relationship between subjective social status and neural processing of race. Together, these results demonstrate that subjective social status shapes the way the brain responds to race, which may have implications for psychopathology.
Evaluation of setting time and compressive strength of a new bone cement precursor powder containing Mg–Na–Ca

Taking the advantage of a novel magnesium phosphate precursor containing Na and Ca, the cementation rate of the cement, including only Mg/Mg–Na–Ca, was studied. Besides, two effective parameters, that is, calcination temperature, 650 °C and 800 °C, and powder-to-cement liquid ratio, 1 and 1.5 g/mL, were assessed. X-ray diffraction, scanning electron microscopy, ion chromatography, particle size analyser, Vicat needle and compression test were used to characterize the powders and obtained cements. The sample containing Mg–Na–Ca, calcined at 800 °C with powder-to-cement liquid ratio of 1.5, obtained the highest compressive strength, 20 MPa, but set fast. To control the kinetics of cementation, the powder containing Mg–Na–Ca calcined at 950 °C with powder-to-cement liquid ratio of 1.5 and 2 g/mL was assessed and the one with 2 g/mL set in 9 min possessing 22 MPa compressive strength was selected as optimal condition to be used as a candidate, injectable bone cement.
Immune play: defending the liver.

for liver infection and cancer. The core tenet of cancer immunotherapy has been the realization that specific T cells can recognize human tumor-derived and tumor-specific antigens [2,3] . Immunogenic modula-tion of hepatocellular carcinoma (HCC) has been proposed, given the noted CD8+ specific T cells in response to antigens such as AFP, cancer testes antigen (NY-ESO-1) and glypi-can-3 (GPC-3), [4] and the correlation between the ratio of HCC-infiltrating CD8+ cells and progression-free survival [5] . Despite this, these immune responses have not been shown to have an impact on the growth of HCC.
Rapid, field-deployable method for collecting and preserving plant metabolome for biochemical and functional characterization

Study of plant metabolome is a growing field of science that catalogs vast biochemical and functional diversity of phytochemicals. However, collecting and storing samples of plant metabolome, sharing these samples across the scientific community and making them compatible with bioactivity assays presents significant challenges to the advancement of metabolome research. We have developed a RApid Metabolome Extraction and Storage (RAMES) technology that allows efficient, highly compact, field-deployable collection and storage of libraries of plant metabolome. RAMES technology combines rapid extraction with immobilization of extracts on glass microfiber filter discs. Two grams of plant tissue extracted in ethanol, using a specially adapted Dremel® rotary tool, produces 25–35 replicas of 10 mm glass fiber discs impregnated with phytochemicals. These discs can be either eluted with solvents (such as 70% ethanol) to study the metabolomic profiles or used directly in a variety of functional assays. We have developed simple, non-sterile, anti-fungal, anti-bacterial, and anti-oxidant assays formatted for 24-multiwell plates directly compatible with RAMES discs placed inside the wells. Using these methods we confirmed activity in 30 out of 32 randomly selected anti-microbial medicinal plants and spices. Seven species scored the highest activity (total kill) in the anti-bacterial (bacteria from human saliva) and two anti-fungal screens (Fusarium spp. and Saccharomyces cerevisiae), providing functional validation of RAMES technology. RAMES libraries showed limited degradation of compounds after 12 months of storage at -20°C, while others remained stable. Fifty-eight percent of structures characterized in the extracts loaded onto RAMES discs could be eluted from the discs without significant losses. Miniaturized RAMES technology, as described and validated in this manuscript offers a labor, cost, and time-effective alternative to conventional collection of phytochemicals. RAMES technology enables creation of comprehensive metabolomic libraries from various ecosystems and geographical regions in a format compatible with further biochemical and functional studies.
Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions

Abstract The spatiotemporal program of metazoan DNA replication is regulated during development and altered in cancers. We have generated novel OK-seq, Repli-seq and RNA-seq data to compare the DNA replication and gene expression programs of twelve cancer and non-cancer human cell types. Changes in replication fork directionality (RFD) determined by OK-seq are widespread but more frequent within GC-poor isochores and largely disconnected from transcription changes. Cancer cell RFD profiles cluster with non-cancer cells of similar developmental origin but not with different cancer types. Importantly, recurrent RFD changes are detected in specific tumour progression pathways. Using a model for establishment and early progression of chronic myeloid leukemia (CML), we identify 1027 replication initiation zones (IZs) that progressively change efficiency during long-term expression of the BCR-ABL1 oncogene, being twice more often downregulated than upregulated. Prolonged expression of BCR-ABL1 results in targeting of new IZs and accentuation of previous efficiency changes. Targeted IZs are predominantly located in GC-poor, late replicating gene deserts and frequently silenced in late CML. Prolonged expression of BCR-ABL1 results in massive deletion of GC-poor, late replicating DNA sequences enriched in origin silencing events. We conclude that BCR-ABL1 expression progressively affects replication and stability of GC-poor, late-replicating regions during CML progression.
Die wichtigsten Krankheiten und Schädlinge der Edelkastanie

Zusammenfassung: Die Edelkastanie entstammt phylogenetisch aus asiatischen Kastanienarten und hat sich ohne den selektiven Druck durch gewisse spezifische Krankheiten und Schädlinge wie den Kastanienrindenkrebs und der aus Asien stammenden Kastaniengallwespe weiterentwickelt. In diesem Beitrag präsentieren wir den historischen Verlauf und den aktuellen Stand der drei importierten Hauptgegenspieler der Edelkastanie: die Asiatische Edelkastaniengallwespe (erstmals gemeldet in Europa im Jahr 2002), den Kastanienrindenkrebs (Erstmeldung in Europa im Jahr 1938) und die Tintenkrankheit, eine Kastanienkrankheit, deren Ursprung und Erstmeldung für Europa nicht vollständig geklärt ist. Dabei veranschaulichen wir, wie die Edelkastanie bedingt durch ihren Ursprung und aufgrund ihrer Kultivierungsgeschichte sehr anfällig auf diese spezifischen Schädlinge und Krankheiten ist. Für die Zukunft ist es deshalb besonders wichtig, dass diese Baumart möglichst unter idealen Standortund Umweltverhältnissen kultiviert wird. Ideale Wuchsbedingungen minimieren krankheitsbedingte Risiken und leisten ebenfalls einen entscheidenden Beitrag zur Minimierung der Auswirkungen von allfälligen Schädlingsbefällen für diese Baumart.
Near-Term Decrease in Brain Volume following Mild Traumatic Injury Is Detectible in the Context of Preinjury Volumetric Stability: Neurobiologic Insights from Analysis of Historical Imaging Examinations

BACKGROUND AND PURPOSE: Neurodegeneration after mild traumatic brain injury may manifest as decreasing regional brain volume that evolves from months to years following mild traumatic brain injury and is associated with worse clinical outcomes. We hypothesized that quantitative brain volume derived from CT of the head, performed for clinical indications during routine care, would change with time and provide insights into the putative neuroinflammatory response to mild traumatic brain injury. MATERIALS AND METHODS: We searched the electronic medical record of our institution for NCCTs of the head performed in patients with mild traumatic brain injury and included those who also underwent NCCTs of the head 1 month to 1 year before and after mild traumatic brain injury for an indication unrelated to trauma. Controls underwent 3 sequential NCCTs of the head with indications unrelated to trauma. The whole-brain and intracranial volume groups were computed using ITK-SNAP. Brain volumes normalized to intracranial volumes were compared across time points using the Wilcoxon signed-rank test. RESULTS: We identified 48 patients from 2005 to 2015 who underwent NCCTs of the head in the emergency department for mild traumatic brain injury and had NCCTs of the head performed both before and after mild traumatic brain injury. Median normalized brain volumes significantly decreased on the follow-up study post-mild traumatic brain injury (0.86 versus 0.84, P < .001) and were similar compared with pre-mild traumatic brain injury studies (0.87 versus 0.86, P = .927). There was no significant difference between normalized brain volumes in the 48 controls. CONCLUSIONS: A decrease in brain volume following mild traumatic brain injury is detectable on CT and is not seen in similar patients with non-mild traumatic brain injury during a similar timeframe. Given the stability of brain volume before mild traumatic brain injury, CT volume loss may represent the subtle effects of neurodegeneration.
Snail mediates repression of the Dlk1-Dio3 locus in lung tumor-infiltrating immune cells

The epithelial-mesenchymal transition-inducing transcription factor Snail contributes to tumor progression in different malignancies. In the present study, we used a transcriptomics approach to elucidate the mechanism of Snail-mediated tumor growth promotion in a KrasLSL-G12D/+;p53fl/fl mouse model of lung adenocarcinoma. We discovered that Snail mediated the downregulation of the imprinted Dlk1-Dio3 locus, a complex genomic region containing protein-coding genes and non-coding RNAs that has been linked to tumor malignancy in lung cancer patients. The Dlk1-Dio3 locus repression mediated by Snail was found to occur specifically in several populations of tumor-infiltrating immune cells. It could be reproduced in primary splenocytes upon ex vivo culture with conditioned medium from Snail-expressing cancer cell lines, which suggests that a Snail-induced soluble factor secreted by the cancer cells mediates the Dlk1-Dio3 locus repression in immune cells, particularly in lymphocytes. Our findings furthermore point towards the contribution of Snail to an inflammatory tumor microenvironment, which is in line with our previous report of the Snail-mediated recruitment of pro-tumorigenic neutrophils to the lung tumors. This underlines an important role for Snail in influencing the immune compartment of lung tumors and thus contributing to disease progression.
Adversarial Over-Sensitivity and Over-Stability Strategies for Dialogue Models

We present two categories of model-agnostic adversarial strategies that reveal the weaknesses of several generative, task-oriented dialogue models: Should-Not-Change strategies that evaluate over-sensitivity to small and semantics-preserving edits, as well as Should-Change strategies that test if a model is over-stable against subtle yet semantics-changing modifications. We next perform adversarial training with each strategy, employing a max-margin approach for negative generative examples. This not only makes the target dialogue model more robust to the adversarial inputs, but also helps it perform significantly better on the original inputs. Moreover, training on all strategies combined achieves further improvements, achieving a new state-of-the-art performance on the original task (also verified via human evaluation). In addition to adversarial training, we also address the robustness task at the model-level, by feeding it subword units as both inputs and outputs, and show that the resulting model is equally competitive, requires only 1/4 of the original vocabulary size, and is robust to one of the adversarial strategies (to which the original model is vulnerable) even without adversarial training.
Schmerztherapie bei Kindern und Jugendlichen mit Hämophilie Handlungsempfehlungen einer Expertengruppe Zusatzmaterial online

Background. Children and adolescents with severe hemophilia commonly suffer from acute and chronic pain as a consequence of hemophilia-related bleeding. Interventionrelated pain also plays a major role. Despite its high prevalence in this patient group, hemophilia-related pain is not always adequately addressed and sufficiently treated. Objectives. This paper discusses how to improve pain management for children and adolescents (0–18 years) with hemophilia and which specific features in this population should influence decisions in pain management. Materials and methods. An expert panel discussed challenges in pain treatment in children and adolescents with hemophilia. Recommendations are based on evidence and clinical experience. Result. Painmanagement in childrenwith hemophilia needs improvement. Children with hemophilia are at risk of developing chronic pain and of suffering traumatization due to insufficient pain management. Pain therapy can be challenging in these children as both their age and the underlying disease limit the options in particular in pain medication. The expert panel developed recommendations to improve pain management in children with hemophilia.
Infants prefer a trustworthy person: An early sign of social cognition in infants

Recently, various studies have clarified that humans can immediately make social evaluations from facial appearance and that such judgment have an important role in several social contexts. However, the origins and early development of this skill have not been well investigated. To clarify the mechanisms for the acquisition of this skill, we examined whether 6- to 8-month-old infants show a preference for a more trustworthy-looking person. Results showed that infants preferred a trustworthy face to an untrustworthy one when both faces were high in dominance. This difference was not seen when both faces were low in dominance. Moreover, this preference disappeared when the faces were upside down. These findings suggest that the perception of trustworthiness based on facial appearance emerges in early development with little social experience. Further research is needed to verify whether infants also perceive other traits, such as competence.