Miracle-dz/UniFAR-FTUs huggingface dataset:
Informational masking by everyday sounds.

Tone-in-noise detection is severely degraded when only a few spectral components of the noise are presented at random on each trial [Neff and Green, Percept. Psychophys. 41, 409-415 (1987)]. The elevations in threshold are attributed to uncertainty regarding the noise caused by sparse sampling of noise components-informational masking is the term used to describe the result. The present experiment was undertaken to determine how informational masking is affected when sparse sampling is from a set of common everyday sounds instead of noise. On each presentation a different masker waveform of constant total power was synthesized from the magnitude and phase of a fixed number, m, of spectral components (m = 2-921 across blocks of trials). The components were selected at random from 1 of 50 common environmental sounds (e.g., baby crying, door slamming, phone ringing), or 1 of 50 samples of Gaussian noise. Masked thresholds for a 1.0-kHz signal in the presence of both types of maskers were obtained using an adaptive, two-interval, forced-choice procedure. Results with noise replicated earlier, results showing largest elevations in threshold for 10-20 sampled components. Results with everyday sounds showed a similar pattern with thresholds elevated above those for noise by as much as 10 dB at the larger values of m. The differences in masked thresholds were systematically related to differences in the ensemble variance of masker spectra, as predicted by a model previously applied to noise [Lutfi, J. Acoust. Soc. Am. 94, 748-758 (1993)]. Not predicted was the result of a subsequent trial-by-trial analysis in which 9-11 dB less masking was observed for samples from everyday sounds rated as easily recognized by listeners. The results suggest that listeners fail to exploit lawful dependencies among spectral components of everyday sounds to aid detection, unless enough information is available for the sound to be easily recognized.
A systematic review on tobacco use among civilian populations affected by armed conflict

Objective To systematically examine evidence on tobacco use among conflict-affected civilian populations. Data sources Primary quantitative and qualitative studies published in English up to April 2014. Bibliographic databases searched were EMBASE, Global Health, MEDLINE, PsycEXTRA, PsycINFO, Web of Science, Cochrane; with the main terms of: (Smoke*, tobacco*, cigarette*, nicotine, beedi, bidi, papirosi, dip, chew, snuff, snus, smokeless tobacco) AND (armed-conflict, conflict-affected, conflict, war, refugee, internally displaced, forcibly displaced, asylum, humanitarian). Grey literature was searched using humanitarian databases, websites and search engines. Study selection Studies were independently selected by two reviewers, with a study outcome of tobacco use and a population of conflict-affected civilian populations such as internally displaced persons, refugees, residents in conflict-affected areas, residents and returning forcibly displaced populations returning in stabilised and postconflict periods. 2863 studies were initially identified. Data extraction Data were independently extracted. The Quality Assessment Tool for Quantitative Studies and the Critical Appraisal Skills Programme for qualitative studies were used to assess study quality. Data synthesis 39 studies met inclusion criteria and descriptive analysis was used. Findings were equivocal on the effect of conflict on tobacco use. Evidence was clearer on associations between post-traumatic stress and other mental disorders with nicotine dependence. However, there were too few studies for definitive conclusions. No study examined the effectiveness of tobacco-related interventions. The quantitative studies were moderate (N=13) or weak (N=22) quality, and qualitative studies were moderate (N=3) or strong (N=2). Conclusions Some evidence indicates links between conflict and tobacco use but substantially more research is required.
Low Energy Proton Single-Event-Upset Test Results on 65 nm SOI SRAM

Experimental results are presented on proton induced single-event-upsets (SEU) on a 65 nm silicon-on-insulator (SOI) SRAM. The low energy proton SEU results are very different for the 65 nm SRAM as compared with SRAMs fabricated in previous technology generations. Specifically, no upset threshold is observed as the proton energy is decreased down to 1 MeV; and a sharp rise in the upset cross-section is observed below 1 MeV. The increase below 1 MeV is attributed to upsets caused by direct ionization from the low energy protons. The implications of the low energy proton upsets are discussed for space applications of 65 nm SRAMs; and the implications for radiation assurance testing are also discussed.
Identification of hepatoprotective flavonolignans from silymarin

Silymarin, also known as milk thistle extract, inhibits hepatitis C virus (HCV) infection and also displays antioxidant, anti-inflammatory, and immunomodulatory actions that contribute to its hepatoprotective effects. In the current study, we evaluated the hepatoprotective actions of the seven major flavonolignans and one flavonoid that comprise silymarin. Activities tested included inhibition of: HCV cell culture infection, NS5B polymerase activity, TNF-α-induced NF-κB transcription, virus-induced oxidative stress, and T-cell proliferation. All compounds were well tolerated by Huh7 human hepatoma cells up to 80 μM, except for isosilybin B, which was toxic to cells above 10 μM. Select compounds had stronger hepatoprotective functions than silymarin in all assays tested except in T cell proliferation. Pure compounds inhibited JFH-1 NS5B polymerase but only at concentrations above 300 μM. Silymarin suppressed TNF-α activation of NF-κB dependent transcription, which involved partial inhibition of IκB and RelA/p65 serine phosphorylation, and p50 and p65 nuclear translocation, without affecting binding of p50 and p65 to DNA. All compounds blocked JFH-1 virus-induced oxidative stress, including compounds that lacked antiviral activity. The most potent compounds across multiple assays were taxifolin, isosilybin A, silybin A, silybin B, and silibinin, a mixture of silybin A and silybin B. The data suggest that silymarin- and silymarin-derived compounds may influence HCV disease course in some patients. Studies where standardized silymarin is dosed to identify specific clinical endpoints are urgently needed.
Differential expression of a human endogenous retrovirus E transmembrane envelope glycoprotein in normal, psoriatic and atopic dermatitis human skin

Background Psoriasis is a common inflammatory skin disease characterized by uncontrolled proliferation of keratinocytes and recruitment of T lymphocytes into the skin. The possible role of human endogenous retroviruses (HERVs) in the induction of psoriasis has been suggested, based upon the previous observations of retrovirus‐like particles in psoriasis from skin lesional plaques, urine and stimulated lymphocytes.
Integrated Global-Local Metric Learning for Person Re-identification

The task of person re-identification (re-id) is to match images of people observed in different camera views. Recent researches mainly focus on feature representation and metric learning. Many global metric learning approaches have achieved good performance. Since comparing all of the samples with a single global metric is inappropriate to handle heterogeneous data, some local metric learning approaches are proposed. But most of them cannot be used on re-id directly due to some research challenges. Also, they usually need complicated computation to solve the optimization problems with numerous parameters. In order to improve the performance of global metric learning and avoid complex computation, we propose to simultaneously learn local metrics on clusters of samples softly partitioned by Gaussian Mixture Model (GMM) and a global metric on the entire training set. Then the local metrics are combined with the global metric by their posterior probabilities of GMM to obtain an integrated metric for similarity evaluation. Experiments on three challenging datasets (VIPeR, PRID450S and QMUL GRID) verify the effectiveness of the proposed method.
Novel Multilayer Dipoles for Wireless Inter-/Intraconnects

A novel multi-metal-layer dipole antenna, in which some identical dipoles are deployed on different metal layers and effectively connected by the feeding and shorting vias, is proposed for wireless inter-/intraconnects. An accurate equivalent model is also presented for better understanding of its physical fundamentals. Simulations show that a six-layer dipole typically has a size reduction of 13.0% and a bandwidth enhancement of 35.3% compared with the corresponding one-layer dipole. An example chip carrying one- and six-layer dipoles was also fabricated through a 0.18-¿m mixed-mode process and on-wafer characterized with full two-port measurements. The experimental results show that further size reduction and bandwidth enhancement could be obtained due to the loadings of lossy vias in six-layer dipoles, and the transmission coefficients of multilayer dipoles could also be improved for the in-phase additive contributions of dipoles on different layers. The propagation mechanisms of wireless intraconnects were evaluated and discussed with the assistance of path-loss coefficient ¿, and it is revealed that the propagation is mostly through the surface waves when the dipole operate far below its resonant frequency, while the space-wave propagation would dominate when approaching the resonant frequency.
The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2

Interferon resistance of vaccinia virus is mediated by specific inhibition of phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF-2 alpha) by the double-stranded-RNA-activated (DAI) protein kinase. Vaccinia virus encodes a homolog of eIF-2 alpha, K3L, the deletion of which renders the virus sensitive to interferon treatment. We have studied the mechanism by which this protein product elicits interferon resistance in a transient DNA transfection system designed to evaluate regulators of eIF-2 alpha phosphorylation. In this system, translation of a reporter gene mRNA is inefficient because of eIF-2 phosphorylation mediated by the DAI protein kinase. Cotransfection of the K3L gene enhances translation of the reporter mRNA in this system. The K3L protein inhibits eIF-2 alpha phosphorylation and DAI kinase activation, apparently without being phosphorylated itself. Inhibition of protein synthesis, elicited by expression of a mutant Ser-51----Asp eIF-2 alpha designed to mimic a phosphorylated serine, is not relieved by the presence of K3L, suggesting that K3L cannot bypass a block imposed by eIF-2 alpha phosphorylation. The results suggest that K3L acts as a decoy of eIF-2 alpha to inhibit DAI kinase autophosphorylation and activation. Another vaccinia virus gene product, K1L, which is required for growth of vaccinia virus on human cells, does not enhance translation in this assay.
Cell behaviors underlying notochord formation and extension in avian embryos: Quantitative and immunocytochemical studies

Formation and extension of the notochord is one of the earliest and most obvious events of axis development in vertebrate embryos. In birds, prospective notochord cells arise from Hensen's node and come to lie beneath the midline of the neural plate, where they assist in the process of neurulation and initiate the dorsoventral patterning of the neural tube through sequential inductive interactions. In the present study, we examined notochord development in avian embryos with quantitative and immunological procedures. Extension of the notochord occurs principally through accretion, that is, the addition of cells to its caudal end, a process that involves considerable cell rearrangement at the notochord‐Hensen's node interface. In addition, cell division and cell rearrangement within the notochord proper contribute to notochord extension. Thus, extension of the notochord occurs in a manner that is significantly different from that of the adjacent, overlying, midline region of the neural plate (i.e., the median hinge‐point region or future floor plate of the neural tube), which as shown in one of the previous studies from our laboratory (Schoenwolf and Alvarez: Development 106:427–439, 1989), extends caudally as its cells undergo two rounds of mediolateral cell‐cell intercalation and two‐three rounds of cell division. © 1993 Wiley‐Liss, Inc.
Assessment of anxiety in long-term care: examination of the Geriatric Anxiety Inventory (GAI) and its short form

ABSTRACT Background: Accurate assessment of anxiety in later life is critical, as anxiety among older adults is associated with social and functional impairment and poorer quality of life. The Geriatric Anxiety Inventory (GAI) and the GAI–Short Form (GAI-SF) were designed to detect anxiety symptoms among community-dwelling older adults, but the usefulness of the GAI and GAI-SF in long-term care is unknown. The present study examined the psychometric properties of the GAI and GAI-SF among residents at a long-term care facility. Methods: Seventy-five nursing home residents completed the GAI and measures of depression, executive functioning, and adaptive functioning. The mean age of residents was 69.60 years (SD = 10.76). Psychiatric diagnoses included dementia, psychotic disorders, mood disorders, anxiety disorders, substance abuse, sleep disorders, and mental retardation. Results: Internal consistency of the GAI was good (α = 0.92) and the GAI-SF was adequate (α = 0.73). GAI and GAI-SF scores were moderately correlated with depression scores, and weakly correlated with adaptive functioning scores and executive functioning scores, suggesting discriminant validity. Logistic regression analyses were conducted with GAI and GAI-SF scores predicting an anxiety disorders diagnosis. Results provided support for the predictive validity of the GAI and GAI-SF. Sensitivity, specificity, and the percentage of individuals correctly classified at various cut-off scores were also calculated. Conclusions: Both the GAI and GAI-SF appear to be useful tools for assessing anxiety among nursing home residents with psychological disorders. The GAI-SF may be a viable replacement for the GAI as a screener for anxiety in long-term care.
A Structure Design Method for Reduction of MRI Acoustic Noise

The acoustic problem of the split gradient coil is one challenge in a Magnetic Resonance Imaging and Linear Accelerator (MRI-LINAC) system. In this paper, we aimed to develop a scheme to reduce the acoustic noise of the split gradient coil. First, a split gradient assembly with an asymmetric configuration was designed to avoid vibration in same resonant modes for the two assembly cylinders. Next, the outer ends of the split main magnet were constructed using horn structures, which can distribute the acoustic field away from patient region. Finally, a finite element method (FEM) was used to quantitatively evaluate the effectiveness of the above acoustic noise reduction scheme. Simulation results found that the noise could be maximally reduced by 6.9 dB and 5.6 dB inside and outside the central gap of the split MRI system, respectively, by increasing the length of one gradient assembly cylinder by 20 cm. The optimized horn length was observed to be 55 cm, which could reduce noise by up to 7.4 dB and 5.4 dB inside and outside the central gap, respectively. The proposed design could effectively reduce the acoustic noise without any influence on the application of other noise reduction methods.
Identification of the origin of adrenergic and cholinergic nerve fibers within the superior hypogastric plexus of the human fetus

Nerve fibers contributing to the superior hypogastric plexus (SHP) and the hypogastric nerves (HN) are currently considered to comprise an adrenergic part of the autonomic nervous system located between vertebrae (T1 and L2), with cholinergic aspects originating from the second to fourth sacral spinal segments (S2, S3 and S4). The aim of this study was to identify the origin and the nature of the nerve fibers within the SHP and the HN, especially the cholinergic fibers, using computer‐assisted anatomic dissection (CAAD). Serial histological sections were performed at the level of the lumbar spine and pelvis in five human fetuses between 14 and 30 weeks of gestation. Sections were treated with histological staining [hematoxylin‐eosin (HE) and Masson's trichrome (TriM)] and with immunohistochemical methods to detect nerve fibers (anti‐S100), adrenergic fibers (anti‐TH), cholinergic fibers (anti‐VAChT) and nitrergic fibers (anti‐nNOS). The sections were then digitalized using a high‐resolution scanner and the 3D images were reconstructed using winsurf software. These experiments revealed the coexistence of adrenergic and cholinergic fibers within the SHP and the HNs. One‐third of these cholinergic fibers were nitrergic fibers [anti‐VACHT (+)/anti‐NOS (+)] and potentially pro‐erectile, while the others were non‐nitrergic [anti‐VACHT (+)/anti‐NOS (−)]. We found these cholinergic fibers arose from the lumbar nerve roots. This study described the nature of the SHP nerve fibers which gives a better understanding of the urinary and sexual dysfunctions after surgical injuries.
“Pulse” Nasal Mupirocin Maintenance Regimen in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis

Abstract Objective: To determine, among patients undergoing continuous ambulatory peritoneal dialysis (CAPD) who were Staphylococcus aureus nasal carriers, if periodic brief “pulses” of nasal mupirocin calcium ointment 2% after completion of a mupirocin eradication protocol would maintain these patients free of carriage. Design: Noncomparative, nonblinded study with historical controls. Setting: A county medical center. Patients: Patients in a CAPD program during the period April 1996 to May 1998. Methods: All patients in the CAPD program had monthly nasal cultures for S aureus. After informed consent, S aureus nasal carriers were administered mupirocin to the nares twice a day for 5 days followed by nasal mupirocin twice monthly. Peritonitis and exit-site infection rates were monitored independently by CAPD nursing staff. Patients were monitored monthly for adverse effects of mupirocin and compliance with the maintenance regimen. Results: Twenty-four patients in the CAPD program were enrolled in the study and had a median duration of follow-up of 8.5 months. Fifteen (63%) of the 24 patients remained free of nasal carriage on follow-up cultures. Of the 9 patients with positive nasal cultures during the study, 8 had only one positive culture. There was no significant difference in the mean yearly peritonitis rate or S aureus peritonitis rate (January 1995-May 1998). However, there was a significant decrease in the mean yearly exit-site infection rates both overall (from 8.8 episodes per 100 patients dialyzed per month in 1995 to 4.0 in 1998; P=.008) and due to S aureus (from 5.6 in 1995 to 0.9 in 1998; P=.03). Adverse effects of nasal mupirocin were mild overall; 1 patient was removed from the study due to an allergic reaction to mupirocin. Conclusions: Among CAPD patients who were S aureus nasal carriers, periodic brief treatment with nasal mupirocin after an initial eradication regimen kept them free of carriage, for the most part, with few adverse effects. The pulse mupirocin regimen offers simplicity and possibly better compliance, as well as minimizing exposure to this agent, thereby possibly reducing the risk of resistance. Further studies are warranted to compare this regimen to other commonly used mupirocin maintenance regimens in dialysis patients.
Spatiotemporal visualization of deep brain stimulation‐induced effects in the subthalamic nucleus

Deep brain stimulation (DBS) is a successful surgical therapy used to treat the disabling symptoms of movement disorders such as Parkinson’s disease. It involves the chronic stimulation of disorder‐specific nuclei. However, the mechanisms that lead to clinical improvements remain unclear. Consequently, this slows the optimization of present‐day DBS therapy and hinders its future development and application. We used a computational model to calculate the distribution of electric potential induced by DBS and study the effect of stimulation on the spiking activity of a subthalamic nucleus (STN) projection neuron. We previously showed that such a model can reveal detailed spatial effects of stimulation in the vicinity of the electrode. However, this multi‐compartmental STN neuron model can fire in either a burst or tonic mode and, in this study, we hypothesized that the firing mode of the cell will have a major impact on the DBS‐induced effects. Our simulations showed that the bursting model exhibits behaviour observed in studies of high‐frequency stimulation of STN neurons, such as the presence of a silent period at stimulation offset and frequency‐dependent stimulation effects. We validated the model by simulating the clinical parameter settings used for a Parkinsonian patient and showed, in a patient‐specific anatomical model, that the region of affected tissue is consistent with clinical observations of the optimal DBS site. Our results demonstrated a method of quantitatively assessing neuronal changes induced by DBS, to maximize therapeutic benefit and minimize unwanted side effects.
Visualizing jet lag in the mouse suprachiasmatic nucleus and peripheral circadian timing system

Circadian rhythms regulate most physiological processes. Adjustments to circadian time, called phase shifts, are necessary following international travel and on a more frequent basis for individuals who work non‐traditional schedules such as rotating shifts. As the disruption that results from frequent phase shifts is deleterious to both animals and humans, we sought to better understand the kinetics of resynchronization of the mouse circadian system to one of the most disruptive phase shifts, a 6‐h phase advance. Mice bearing a luciferase reporter gene for mPer2 were subjected to a 6‐h advance of the light cycle and molecular rhythms in suprachiasmatic nuclei (SCN), thymus, spleen, lung and esophagus were measured periodically for 2 weeks following the shift. For the SCN, the master pacemaker in the brain, we employed high‐resolution imaging of the brain slice to describe the resynchronization of rhythms in single SCN neurons during adjustment to the new light cycle. We observed significant differences in shifting kinetics among mice, among organs such as the spleen and lung, and importantly among neurons in the SCN. The phase distribution among all Period2‐expressing SCN neurons widened on the day following a shift of the light cycle, which was partially due to cells in the ventral SCN exhibiting a larger initial phase shift than cells in the dorsal SCN. There was no clear delineation of ventral and dorsal regions, however, as the SCN appear to have a population of fast‐shifting cells whose anatomical distribution is organized in a ventral–dorsal gradient. Full resynchronization of the SCN and peripheral timing system, as measured by a circadian reporter gene, did not occur until after 8 days in the advanced light cycle.