Miracle-dz/UniFAR-FTUs huggingface dataset:
An investigation of factors that influence student and team outcomes in entrepreneurship education

This thesis investigates the impact of individual, team and pedagogical factors on individual and team level outcomes in the context of entrepreneurship education. Despite the growth in research focused on entrepreneurship education in recent decades, there are on-going concerns about methodological rigor within the domain. Furthermore, few researchers have explored the student team in entrepreneurship education. Drawing primarily on Social Cognitive Career Theory and the Input-Mediator-Output framework, this study explores the influence of factors such as entrepreneurial self-efficacy, entrepreneurial intentionality, creativity, and entrepreneurial experience on individual and student team outcomes. A series of four quantitative studies were conducted, drawing on 1,004 third-level students and 185 student teams. In synthesising the findings with extant knowledge, a definition and research framework for the student team in entrepreneurship education is presented. The key findings indicate that in entrepreneurship education, students with entrepreneurial experience have higher entrepreneurial intentionality and founding passion, while student teams with entrepreneurship experience are associated with better team processes, higher performance, and more innovative outcomes. Furthermore, entrepreneurial self-efficacy predicts entrepreneurial intentions, subject interest, and reduces social loafing. In addition, perceptions of creativity, creativity training, and supportive climates for innovation (team and institutional) are positive predictors of individual and team outcomes. The study provides a critical review of prominent entrepreneurship theories, and provides a contextual revision of an individual trait-based measure of entrepreneurial tendencies. By using novel operationalisations of key constructs the team-level studies, greater insight into team emergent states and misalignment is provided. It is the first study to examine cognitive team separation variables in context. Pedagogically, the four studies provide actionable insights for the educator in areas such as training, team selection, and mitigation of social loafing, thus enhancing the delivery of entrepreneurship education, and supporting a stronger ecosystem conducive to student entrepreneurial development.
Melioidosis in 6 tsunami survivors in southern Thailand.

BACKGROUND Six cases of melioidosis were identified in survivors of the 26 December 2004 tsunami who were admitted to Takuapa General Hospital in Phangnga, a region in southern Thailand where melioidosis is not endemic. All 6 cases were associated with aspiration, and 4 were also associated with laceration. METHODS We compared the clinical, laboratory, and radiographic findings and the outcomes for these 6 patients with those for 22 patients with aspiration-related melioidosis acquired during 1987-2003 in a melioidosis-endemic region in northeast Thailand. Results of tests for detection of Burkholderia pseudomallei in soil specimens from Phangnga and from northeast Thailand were compared. RESULTS The 6 patients (age range, 25-65 years) presented with signs and symptoms of pneumonia 3-38 days (median duration, 6.5 days) after the tsunami. Chest radiograph findings at the onset of pneumonia were abnormal in all cases; 1 patient developed a lung abscess. B. pseudomallei was grown in blood cultures in 3 cases and in cultures of respiratory secretions in 4 cases. Two patients required ventilation and inotropes; 1 patient died. Compared with tsunami survivors, patients with aspiration-related melioidosis in northeast Thailand had a shorter interval (median duration, 1 day) between aspiration and onset of pneumonia; were more likely to exhibit shock, respiratory failure, renal failure, and/or altered consciousness (P=.03); and had a higher in-hospital mortality (64% [14 of 22 patients]; P=.07). These differences may be related to the severity of the near-drowning episode, the inhalation of sea water versus fresh water, the size of bacterial inoculum, and the possible acquisition (among tsunami survivors) of B. pseudomallei via laceration. Only 3 (0.8%) of 360 soil samples from Phangnga were positive for B. pseudomallei, compared with 26 (20%) of 133 samples from northeast Thailand (P<.0001). CONCLUSIONS Tsunami survivors are at increased risk of melioidosis if they are injured in an environment containing B. pseudomallei.
Politicized CSR: How corporate political activity (mis-)uses political CSR

In this article, we posit that corporate political activities (CPA) such as lobbying make use of corporate social responsibility (CSR) to advance instrumental goals. We juxtapose the theoretical foundations of the normative concept of political CSR and the strategic notion of nonmarket strategy to show that they are in opposition conceptually regarding the role of corporations in public policy. Using a systematic theoretical comparison along seven dimensions, we discuss the juxtapositions and identify the common ground of the two theories. Building on examples from the alcohol industry, we describe how CPA uses instrumental CSR to advance goals in public policy—we call this politicized CSR. Hence, we illustrate the shift from political to politicized CSR, a misuse of CSR for purposes of CPA, and discuss consequences for the theory and practice of public affairs and CSR.
Dynamic performance of triple-active bridge converter rated at 400 V, 10 kW, and 20 kHz

An autonomous DC microgrid system with triple-active bridge (TAB) converters as power-routing units has been proposed. To investigate the next-generation smart grid in which each port has loads, batteries, or energy resources and multiple TAB converters connect to each other, it is necessary to construct a computer simulation model of a TAB converter using a typical power electronics simulator. In this paper, we develop such a computer simulation model equivalent to a prototype TAB converter that is rated at 400 V, 10 kW, and 20 kHz. The computer simulation model will be useful for dynamic performance analysis and control design of TAB converter applications.
Lipid Vesicles for the Skin Delivery of Diclofenac: Cerosomes vs. Other Lipid Suspensions.

PURPOSE Lipid suspensions as drug carriers, including conventional liposomes, ethosomes, transferosomes, proniosomes, niosomes, PEG-PPG-PEG niosomes and stratum corneum liposomes (cerosomes), were formulated and compared. METHODS Lipid vesicles were formulated and assessed with regards to enhancement of skin permeation of diclofenac and stability profiles of the formulations. Formulation-induced changes of the biophysical structure of excised human skin were monitored using the Fourier transform infrared spectroscopy. RESULTS The stability profiles of these suspensions over 12 weeks did not show any significant drug leakage from the vesicles of interest (p > 0.05). FTIR observations indicated that the vesicles increased stratum corneum (SC) lipid fluidization and altered protein conformation. Skin permeability experiments showed that the free unencapsulated drug in the cerosomal formulations caused significant increase in drug permeation across the skin (p < 0.01). Low skin permeability of drug from the other lipid suspensions could be due to the entrapment of diclofenac within these vesicles which decreased the solubility of the hydrophilic drug in the skin lipids and the partition coefficient of the drug from these vesicles into the SC. CONCLUSION Optimal drug entrapment in vesicles or alteration of the skin structure may not necessarily enhance the permeation of hydrophilic drugs across the human skin. These lipid vesicles may be further developed into carriers of both hydrophilic and hydrophobic drugs for topical and transdermal delivery, respectively.
The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation

In the last few years, several genes involved in X-specific mental retardation (MR) have been identified by using genetic analysis. Although it is likely that additional genes responsible for idiopathic MR are also localized on the autosomes, cloning and characterization of such genes have been elusive so far. Here, we report the isolation of a previously uncharacterized gene, MEGAP, which is disrupted and functionally inactivated by a translocation breakpoint in a patient who shares some characteristic clinical features, such as hypotonia and severe MR, with the 3p− syndrome. By fluorescence in situ hybridization and loss of heterozygosity analysis, we demonstrated that this gene resides on chromosome 3p25 and is deleted in 3p− patients that present MR. MEGAP/srGAP3 mRNA is predominantly and highly expressed in fetal and adult brain, specifically in the neurons of the hippocampus and cortex, structures known to play a pivotal role in higher cognitive function, learning, and memory. We describe several MEGAP/srGAP3 transcript isoforms and show that MEGAP/srGAP3a and -b represent functional GTPase-activating proteins (GAP) by an in vitro GAP assay. MEGAP/srGAP3 has recently been shown to be part of the Slit-Robo pathway regulating neuronal migration and axonal branching, highlighting the important role of MEGAP/srGAP3 in mental development. We propose that haploinsufficiency of MEGAP/srGAP3 leads to the abnormal development of neuronal structures that are important for normal cognitive function.
Facing change: forms and foundations of contemporary adaptation to biotic invasions

Ongoing adaptation in native populations to anthropogenic change both facilitates and challenges ecologically appropriate and sustainable management. Human disturbance promotes adaptive responses at the genomic, individual and population levels. Traits vary widely in whether adaptation occurs through plasticity or evolution, and these modes interact within and among traits. For example, plasticity in one trait may be adaptive because it permits homeostasis and lessens the intensity of selection in another. Both opportunity and catastrophe generate adaptive responses. Recently evolved adaptations characterize the responses of many native species to biotic invasions. Several well‐known examples involve native phytophagous insects colonizing introduced plants. For example, our studies of North American and Australian soapberry bugs on nonindigenous plants demonstrate both diversifying and homogenizing contemporary evolution. Modes of adaptation differ among traits and populations and as a function of the host on which they develop. The genetic architecture of the evolving adaptations involves a substantial degree of nonadditive genetic variation. One important consequence of contemporary adaptation may be an enhanced capacity of native communities to provide adaptive biological control of invasive species. Conservation scientists may manipulate adaptation to achieve conservation goals, but must also decide how deeply they wish to attempt to control the phenotypes and genotypes of other species.
Interferon Action: Inhibition of Vesicular Stomatitis Virus RNA Synthesis Induced by Virion-Bound Polymerase

The particle-bound RNA polymerase activity of vesicular stomatitis virus (VSV) can be demonstrated in vivo. Linear synthesis of viral RNA persists for 5 to 6 hours at 34�C in infected monolayers of chick embryo cells treated with cycloheximide and actinomycin D to block synthesis of protein and cell-specific RNA. At least 55 percent of the RNA made under these conditions is complementary to virion RNA. RNA synthesis mediated by VSV polymerase activity is inhibited in cells first treated with chick-derived interferon or polyriboinosinate• polyribocytidylate, but not by mouse interferon. The RNA product of VSV polymerase activity is present throughout the cytoplasm, and its synthesis is inhibited by the interferon system, as judged by autoradiographs that show the physical distribution, in cells, of RNA produced by virion polymerase in the absence of translation—a demonstration of the transcription product of the viral genome.
The impact of monetary strategies on economic growth: an empirical analysis for Pakistan

The present study aims to check the long run relationship between monetary variables and gross domestic product. The study has used the yearly data for the periods of 30 years from 1983 to 2013. It is concluded that GDP is positively associated with M2, government expenditures, and inflation. While it is negatively related with interest rate, growth becomes possible with low interest rate. Investment opportunities are increased in economy. With currency appreciation, it has positive impact on growth. Domestic products are cheaper that compete in international markets and BOP becomes favorable. Due to increase in government borrowing from SBP for development purposes money supply increases. Money supply firstly effects the growth, and then it shows the impact on inflation. Due to the increase in the demand of goods output increases and it generates more employment opportunities. Lower interest rate encourages the investor to invest with the result employment increases. These monetary policies increase output growth through money supply which has short run effect. Most of the developing countries lag behind in attaining the objectives and goals of monetary policy. The main hurdles are to increase internal government borrowing and inflation pressure which destabilize the entire economy.
Elements of a Schumpeterian catalytic research and innovation policy

In this article we take a fresh look at Research and Innovation (R&I hereinafter) policy and define a new notion: Schumpeterian catalytic R&I policy. Such policy style amends and enriches the new mission-oriented framework for innovation policy by assigning more weight to the microeconomic dimension of private actors’ actions and by being more concerned with the temporary nature of interventions. We relate our argument to recent empirical trends in productivity dynamics and innovative activities. These suggest that an innovation slowdown is taking place and, consequently, that a renewed interest in the (re-)direction—rather than on the intensity of innovative activities—is key to the design of R&I policy capable to tackle current challenges. We use the evidence to build a schematic theoretical framework to inform policy design, and we outlined the defining features of our proposed policy style.
Looking east: The European Union's new FTA negotiations in Asia

By Razeen Sally The European Centre for International Political Economy (ECIPE) is an independent and non-profit policy research think tank dedicated to trade policy and other international economic policy issues of importance to Europe. ECIPE is rooted in the classical tradition of free trade and an open world economic order. ECIPE’s intention is to subject international economic policy, particularly in Europe, to rigorous scrutiny of costs and benefits, and to present conclusions in a concise, readily accessible form to the European public. We aim to foster a “culture of evaluation” – largely lacking in Europe – so that better public awareness and understanding of complex issues in concrete situations can lead to intelligent discussion and improved policies. That will be ECIPE’s contribution to a thriving Europe in an open world.
A Fast SVM-Based Tongue's Colour Classification Aided by k-Means Clustering Identifiers and Colour Attributes as Computer-Assisted Tool for Tongue Diagnosis

In tongue diagnosis, colour information of tongue body has kept valuable information regarding the state of disease and its correlation with the internal organs. Qualitatively, practitioners may have difficulty in their judgement due to the instable lighting condition and naked eye's ability to capture the exact colour distribution on the tongue especially the tongue with multicolour substance. To overcome this ambiguity, this paper presents a two-stage tongue's multicolour classification based on a support vector machine (SVM) whose support vectors are reduced by our proposed k-means clustering identifiers and red colour range for precise tongue colour diagnosis. In the first stage, k-means clustering is used to cluster a tongue image into four clusters of image background (black), deep red region, red/light red region, and transitional region. In the second-stage classification, red/light red tongue images are further classified into red tongue or light red tongue based on the red colour range derived in our work. Overall, true rate classification accuracy of the proposed two-stage classification to diagnose red, light red, and deep red tongue colours is 94%. The number of support vectors in SVM is improved by 41.2%, and the execution time for one image is recorded as 48 seconds.
Radiation therapy for intracranial germinoma: results of the German cooperative prospective trials MAKEI 83/86/89.

PURPOSE A multicenter prospective trial was conducted (Maligue Keimzelltümoren [MAKEI] 83/86/89) to assess outcome in intracranial germinoma after treatment with radiotherapy alone at reduced doses. PATIENTS AND METHODS Between 1983 and 1993, 60 patients with histologically (n = 58) or cytologically (n = 2) confirmed germinoma were enrolled onto the study. Patients received radiotherapy alone (craniospinal axis/local boost). In the MAKEI 83/86 study (involving 11 patients), the dose to the craniospinal axis was 36 Gy and the dose to the tumor region was 14 Gy. In the MAKEI 89 study (involving 49 patients), doses were 30 and 15 Gy, respectively. RESULTS Median patient age was 13 years (range, 6 to 31 years). Complete remission was achieved in all patients. The estimated (Kaplan-Meier) 5-year relapse-free survival rate was 91.0% +/- 3.9% at a mean follow-up of 59.5 months (range, 3 to 180 months); the estimated overall survival rate was 93.7% +/- 3.6%. Relapse occurred in five patients 10 to 33 months (mean, 18.4 months) after diagnosis (one patient developed a spinal canal metastasis and underwent salvage radiotherapy and chemotherapy; four patients had metastases outside the CNS and underwent salvage chemotherapy alone). Four patients died: one died from disease, two died from therapy-related complications, and one committed suicide. Acute complications with long-lasting sequelae were tumor or surgery related (three cases of blindness, six of reduced vision, two of hemiparesis). Psychosocial development was normal in the majority of patients. CONCLUSION Radiotherapy directed toward the craniospinal axis or tumor site alone at decreased dose levels is effective. To reduce the risk of late side effects, further attempts to decrease total doses are justified. In cases of recurrent disease, chemotherapy administered outside the CNS is the treatment of choice.
One hundred consecutive hepatic biopsies in the workup of living donors for right lobe liver transplantation

Living donor liver transplantation allows an increasing number of patients with end‐stage liver disease the opportunity for effective treatment in the face of a critical shortage of cadaveric organs. Hepatic steatosis decreases functional graft mass and may contribute to graft dysfunction. Screening liver biopsy allows accurate quantitation of hepatic fat, but is an invasive procedure that is not universally employed in the evaluation of living donors. We studied 100 consecutive prospective right lobe living donors, all evaluated with liver biopsy, imaging studies, and various clinical parameters. The accuracy and predictive value of body mass index (BMI) and imaging were compared with biopsy in determining the amount of hepatic fat. There were no complications to biopsy, with 33% showing some degree of steatosis. BMI correlated only weakly with biopsy, with 73% of overweight (BMI > 25) donors having little or no hepatic fat. Imaging was only 12% sensitive to small amounts (5% to 10%) of fat, with increasing sensitivity to more severe steatosis. Imaging diagnosed steatosis in 2 donors without hepatic fat and failed to identify a candidate denied with biopsy‐proven 30% steatosis. Conversely, 9% of candidates with BMIs of 25 or less had 10% or greater steatosis. Moreover, three candidates were denied surgery because biopsy detected occult liver disease. Accurate quantification of hepatic fat is not afforded by BMI and imaging studies alone. Screening liver biopsy has a low complication rate and may serve to increase donor safety. Biopsy is essential in identifying donor grafts at risk for poor recipient outcome while maximizing the donor pool.
The role of bacterial surface structures in pathogenesis.

Modern research has revealed that the true surfaces of animal cells consist of polysaccharide chains that are linked to proteins hydrophobically anchored in the membrane and protrude to form a dense glycocalyx. It has become increasingly clear that most pathogenic bacteria must position themselves at the surface of their "target" cell in order to exert their toxic or otherwise deleterious effects. The true surface of most pathogenic bacteria has also been recently shown to consist of a protruding mass of polysaccharide chains--the bacterial glycocalyx--that is composed of teichoic acids in many gram-positive species and of acid polysaccharides in many gram-negative organisms. Through this bacterial glycocalyx certain cell surface proteins and organized protein structures (e.g., pili) are known to project, so that the bacterial surface is a mosaic of polysaccharides and proteins; both of these types of molecules have been implicated in instances of specific pathogenic adhesion. Besides their role in specific adhesion to target cells, these surface components interpose a highly charged, and often very extensive, barrier that can prevent the penetration of antibodies and antibiotics to their target sites in the bacterial cell. They may also frustrate mucociliary clearance, phagocytosis, and other clearance mechanisms of the host. We will discuss the chemical and physical nature of these bacterial surface components that mediate pathogenic adhesion and counteract host defense mechanisms sufficiently to allow infections to become established.
Role of coproantibody in clinical protection of children during reinfection with rotavirus

Rotavirus is the major cause of severe, dehydrating infantile gastroenteritis. Infection is limited to the gut, but the relative roles of serum and secretory copro-immunoglobulin A (IgA) in protection are unclear. Specific copro-IgA is predictive of duodenal antirotaviral IgA and correlates with virus-neutralizing coproantibody. Copro-IgA conversion is a more sensitive marker of rotavirus reinfection than seroconversion. We measured rotavirus reinfections by copro-IgA conversion prospectively in 35 children recruited at a time of severe rotavirus illness. The children were followed up longitudinally for 14 to 31 months to determine whether high coproantibody levels correlated with clinical protection against rotavirus disease. Ninety-four percent of the children experienced reinfection, and 38% developed persistent elevations in specific copro-IgA termed plateaus. Plateau children had a higher mean annual rate of rotavirus infection and a lower ratio of symptomatic to total number of rotavirus reinfections than did nonplateau children. The annual rates of rotavirus infection and disease were significantly higher outside the plateau than inside it in children experiencing antirotavirus copro-IgA plateaus. Frequent rotavirus infection of children appears to stimulate production of a specific copro-IgA plateau which correlates with protection against an excess of infection and symptomatic disease.