Miracle-dz/UniFAR-FTUs huggingface dataset:
A Mobile Medical Knowledge Dissemination Platform (HeadToToe): Mixed Methods Study

Background Finding readily accessible, high-quality medical references can be a challenging task. HeadToToe is a mobile platform designed to allow easy and quick access to sound, up-to-date, and validated medical knowledge and guidance. It provides easy access to essential clinical medical content in the form of documents, videos, clinical scores, and other formats for the day-to-day access and use by medical students and physicians during their pre- and postgraduate education. Objective The aim of this paper is to describe the architecture, user interface, and potential strengths and limitations of an innovative knowledge dissemination platform developed at the University of Geneva, Switzerland. We also report preliminary results from a user-experience survey and usage statistics over a selected period. Methods The dissemination platform consists of a smartphone app. Through an administration interface, content is managed by senior university and hospital staff. The app includes the following sections: (1) main section of medical guidance, organized by clinical field; (2) checklists for history-taking and clinical examination, organized by body systems; (3) laboratory section with frequently used lab values; and (4) favorites section. Each content item is programmed to be available for a given duration as defined by the content’s author. Automatic notifications signal the author when the content is about to expire, hence, promoting its timely updating and reducing the risk of using obsolete content. In the background, a third-party statistical collecting tool records anonymous utilization statistics. Results We launched the final version of the platform in March 2019, both at the Faculty of Medicine at the University of Geneva and at the University Hospital of Geneva in Switzerland. A total of 622 students at the university and 613 health professionals at the hospital downloaded the app. Two-thirds of users at both institutions had an iOS device. During the practical examination period (ie, May 2019) there was a significant increase in the number of active users (P=.003), user activity (P<.001), and daily usage time (P<.001) among medical students. In addition, there were 1086 clinical skills video views during this period compared to a total of 484 in the preceding months (ie, a 108% increase). On a 10-point Likert scale, students and physicians rated the app with mean scores of 8.2 (SD 1.9) for user experience, 8.1 (SD 2.0) for usefulness, and 8.5 (SD 1.8) for relevance of content. In parallel, postgraduate trainees viewed more than 6000 documents during the first 3 months after the implementation in the Division of Neurology at our institution. Conclusions HeadToToe is an educator-driven, mobile dissemination platform, which provides rapid and user-friendly access to up-to-date medical content and guidance. The platform was given high ratings for user experience, usefulness, and content quality and was used more often during the exam period. This suggests that the platform could be used as tool for exam preparation.
Malleability of rumination: An exploratory model of CBT-based plasticity and long-term reduced risk for depressive relapse among youth from a pilot randomized clinical trial

Early-onset depression is associated with increased lifespan chronicity, suicidality, and the functional burdens associated with recurrent episodes. Reduction of these negative long-term outcomes requires an understanding of what interventions reduce vulnerabilities or ameliorate their associated neural patterns. Rumination-Focused Cognitive Behavior Therapy (RFCBT), an evidence-based treatment which directly targets a well-known risk for depressive relapse (i.e., ruminative habit), has shown preliminary success for reducing relapse rates among adolescents and adults in remission from Major Depressive Disorder (rMDD). In the current pilot study, clinical outcomes and neuroimaging predictors are explored over two years following a randomized controlled trial of eight weeks of RFCBT (n = 17) or Assessment Only (AO; n = 16) to prevent depressive relapse among adolescents. Baseline neural activation during a rumination induction task, neural change during treatment, and treatment group are examined as predictors of relapse. Regions selected were based upon hyperactivation patterns in rMDD compared to healthy adolescents, and occurred largely in default mode, somatomotor, visual and salience network regions. Twenty-five adolescents successfully completed quality fMRI scans at Baseline and after eight weeks of RFCBT or AO. RFCBT-treated youth maintained lower depression scores over the two-year period, relapsed at slower and less frequent rates, and were hospitalized less often for suicidality than AO. Although both groups reported lower ruminative tendencies after one year, at two-year follow-up, RFCBT maintained reductions whereas AO reported a return of ruminative tendencies. Adolescents who demonstrated higher activation at Baseline in default mode and limbic regions during rumination induction reported reduced depressive symptoms over the follow-up period. These data offer preliminary evidence that targeting rumination can stave off depressive relapse among vulnerable adolescents, and that such targeted treatment may aid a compensation process for disease-related brain functioning reducing risk to further depressive episodes. Clinical trials registration NCT01905267, https://clinicaltrials.gov/ct2/show/NCT01905267
The genus Dirina (Roccellaceae, Arthoniales) revisited

Abstract Dirina (Roccellaceae, Arthoniales) is a monophyletic genus of crustose, saxicolous or corticolous lichenized fungi. Twenty-four species are accepted in the genus, including nine new species: Dirina angolana, D. arabica, D. astridae, D. canariensis, D. indica, D. madagascariensis, D. pacifica, D. pallescens and D. sorocarpa. A phylogenetic hypothesis is presented based on data from four molecular markers, β-tubulin, ITS 1 and 2, nuLSU and RPB2, including all recognized Dirina species worldwide. New combinations proposed include Dirina badia for Roccellina badia, Dirina jamesii for Roccellina jamesii, Dirina candida for Chiodecton candidum and Dirina teichiodes for Lecidea teichiodes. Two species are reinstated: Dirina approximata and D. monothalamia (as a new name of Chiodecton africanum). Asexual morphs described earlier at the rank forma are no longer recognized as taxonomic units viz., Dirina catalinariae f. sorediata, D. insulana f. sorediata, D. massiliensis f. sorediata, D. paradoxa ssp. paradoxa f. sorediata and D. massiliensis f. aponina. One species, Dirina calcicola, is transferred to Fulvophyton and two other species, Dirina insulae-howensis and Dirina neozelandica, are transferred to Schismatomma. Dirina follmannii is not accepted in Dirina and placed as incertae sedis. A key to the species of Dirina is provided. Vicariance through plate tectonics and continental drift versus long distance dispersal to explain biogeographical patterns is discussed.
Research on Path Planning of Mobile Robot based on A* Algorithm

— Path planning is one of the core issues in the field of intelligent robots, and it is also an important aspect in the study of artificial intelligence in robotics. The typical path planning problem refers to how to find the moving path from the starting point to the ending point for the robot in the working environment with obstacles, so that the robot can pass all obstacles safely and without collision during the movement. Firstly, the paper expounds the concept of mobile robot path planning and introduces the current research situation of mobile path planning. Then it introduces the steps of A* algorithm and A* algorithm implementation, and carries out MATLAB simulation experiment. The experiment proves that the A* algorithm can plan the global optimal path and ensure the fastness and accuracy of the path. It has certain reference significance for the future research of path planning.
The prognostic value of platelet-to-lymphocyte ratio on in-hospital mortality in admitted adult traffic accident patients

Background The predictive value of platelet-to-lymphocyte ratio (PLR) in acute illness is well known, but further evaluation is needed in traffic accident patients. Methods This retrospective observational study enrolled consecutive adult patients involved in traffic accidents who were admitted to the study hospital’s emergency department during 1 year. The initial platelet and lymphocyte counts after arrival at the emergency department were the variables of interest. The primary outcome was in-hospital mortality. Data on baseline characteristics, comorbidities, and physiological and laboratory variables were collected. Multivariate Cox proportional hazard modelings were used to identify the variables independently associated with the outcome. Results A total of 1,522 traffic accident patient were screened, and 488 patients were enrolled. In all, 43 (8.8%) patients died in the hospital. The median PLR was 115.3 (interquartile range 71.3;181.8). The in-hospital mortality rate of the 1st tertile of PLR (21.5%) was significantly higher than the rates of the 2nd (2.5%) and 3rd (2.5%) tertiles. The area under the receiver operating characteristic curve of PLR for in-hospital survival was 0.82 (95% confidential interval [CI], 0.74–0.89), which was greater than that of lymphocyte count (0.72; 95% CI 0.63–0.81) and platelet count (0.67; 95% CI 0.57–0.76). The Kaplan-Meier curves showed a significant difference in survival between the tertiles (p<0.001). The Cox regression model showed that the 2nd tertile of PLR was independently associated with lower in-hospital mortality (adjusted hazard ratio 0.30; 95% CI, 0.09–0.98), compared to the 1st tertile. Conclusion PLR was significantly associated with an increased risk of in-hospital mortality in admitted adult traffic accident patients.
of Oxidative Stress in Human Breast Cancer Cells

Epidemiologic evidence suggests that high dietary intake of Brassica vegetables, such as broccoli, cabbage, and Brussels sprouts, protects against tumorigenesis in multiple organs. 3,3V -Diindolylmethane, one of the active products derived from Brassica vegetables, is a promising antitumor agent. Previous studies in our laboratory showed that 3,3V -diindolylmethane induced a G1 cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that included increased expression of p21. In the present study, the upstream events leading to p21 overexpression were further investigated. We show for the first time that 3,3V -diindolylmethane is a strong mitochondrial H + -ATPase inhibitor (IC50f20 Mmol/L). 3,3V -Diindolylmethane treatment induced hyperpolarization of mitochondrial inner membrane, decreased cellular ATP level, and significantly stimulated mitochondrial reactive oxygen species (ROS) production. ROS production, in turn, led to the activation of stress-activated pathways involving p38 and c-Jun NH2terminal kinase. Using specific kinase inhibitors (SB203580 and SP600125), we showed the central role of p38 and c-Jun NH2terminal kinase (JNK) pathways in 3,3V -diindolylmethaneinduced p21mRNA transcription. In addition, antioxidants significantly attenuated 3,3V -diindolylmethane-induced activation of p38 and JNK and induction of p21, indicating that oxidative stress is the major trigger of these events. To further support the role of ROS in 3,3V -diindolylmethane-induced p21overexpression, we showed that 3,3 V -diindolylmethane failed to induce p21overexpression in mitochondrial respiratory chain deficient R 0 MCF-7 cells, in which 3,3V -diindolylmethane did not stimulate ROS production. Thus, we have established the critical role of enhanced mitochondrial ROS release in 3,3V -diindolylmethane-induced p21up-regulation in human breast cancer cells. (Cancer Res 2006; 66(9): 4880-7)
Understanding marine larval dispersal in a broadcast-spawning invertebrate: A dispersal modelling approach for optimising spat collection of the Fijian black-lip pearl oyster Pinctada margaritifera

Fisheries and aquaculture industries worldwide remain reliant on seed supply from wild populations, with their success and sustainability dependent on consistent larval recruitment. Larval dispersal and recruitment in the marine environment are complex processes, influenced by a multitude of physical and biological factors. Biophysical modelling has increasingly been used to investigate dispersal and recruitment dynamics, for optimising management of fisheries and aquaculture resources. In the Fiji Islands, culture of the black-lip pearl oyster (Pinctada margaritifera) is almost exclusively reliant on wild-caught juvenile oysters (spat), through a national spat collection programme. This study used a simple Lagrangian particle dispersal model to investigate current-driven larval dispersal patterns, identify potential larval settlement areas and compare simulated with physical spat-fall, to inform targeted spat collection efforts. Simulations successfully identified country-wide patterns of potential larval dispersal and settlement from 2012–2015, with east-west variations between bi-annual spawning peaks and circulation associated with El Niño Southern Oscillation. Localised regions of larval aggregation were also identified and compared to physical spat-fall recorded at 28 spat collector deployment locations. Significant and positive correlations at these sites across three separate spawning seasons (r(26) = 0.435; r(26) = 0.438; r(26) = 0.428 respectively, p = 0.02), suggest high utility of the model despite its simplicity, for informing future spat collector deployment. Simulation results will further optimise black-lip pearl oyster spat collection activity in Fiji by informing targeted collector deployments, while the model provides a versatile and highly informative toolset for the fishery management and aquaculture of other marine taxa with similar life histories.
Following the Formation of Silver Nanoparticles Using In Situ X-ray Absorption Spectroscopy

The formation of silver and Au@Ag core@shell nanoparticles via reduction of AgNO3 by trisodium citrate was followed using in situ X-ray absorption near-edge structure (XANES) spectroscopy and time-resolved UV–visible (UV–vis) spectroscopy. The XANES data were analyzed through linear combination fitting, and the reaction kinetics were found to be consistent with first-order behavior with respect to silver cations. For the Au@Ag nanoparticles, the UV–vis data of a lab-scale reaction showed a gradual shift in dominance between the gold- and silver-localized surface plasmon absorbance bands. Notably, throughout much of the reaction, distinct gold and silver contributions to the UV–vis spectra were observed; however, in the final product, the contributions were not distinct.
THE SENSITIVITY OF ECHOLOCATION IN BATS

1. The distance at which bats (Myotis lucifugus) react to the presence of a row of small wires has been measured by a photographic determination of the distance at which the pulse repetition rate first increases as the bats fly towards the wires. Distinct changes in this rate were measured in almost every flight towards wires spaced 30 cm. apart and ranging in diameter from 0.18 to 3 mm.2. The interval between successive pulses averaged 60 to 80 msec as the bats flew along the room towards the row of wires, and dropped to 20-40 msec just before the barrier. The intervals decreased less with the smaller sizes of wire.3. All but the largest of these wires are well below one wave-length of the emitted sounds of these bats (50-60 kc, or 6-7 mm., at the peak intensity and 120 kc, or about 3 mm., at the very beginning of some pulses). 4. Clear evidence that the wires had been detected was furnished at the point where the interval between pulses first dropped significantly below the level that prevailed before an.
Effect of antenatal depression on adverse birth outcomes in Gondar town, Ethiopia: A community-based cohort study

Background The impact of antenatal depression on pregnancy outcomes has been well investigated in developed countries, but few studies have been conducted in low-income countries. As depression is significantly affected by socio-economic and cultural factors, it would be difficult to generalize evidence from high-income countries to low-income countries. We conducted a community-based cohort study to estimate the incidence of adverse birth outcomes and the direct and indirect pathways via which depression and other psychosocial risk factors may impact such birth outcomes within Gondar town, Ethiopia. Methods The study followed 916 pregnant women who were screened for antenatal depression using the Edinburgh Postnatal Depression Scale (EPDS). We also assessed the incidence of preterm births, Low Birth Weight (LBW) and stillbirths. Modified Poisson regression was used to estimate the relative risk of predictors on adverse birth outcomes and a Generalized Structural Equation Model (GSEM) was used to estimate the direct and indirect effect of antenatal depression and other psychological risk factors on adverse birth outcomes. Results The cumulative incidence of stillbirth, LBW and preterm was 1.90%, 5.25%, and 16.42%, respectively. The risk of preterm birth was 1.61, 1.46, 1.49, and 1.77 times higher among participants who identified as Muslim, reported being fearful of delivery, were government employee’s, and who had no antenatal care services, respectively. Partner support moderated the association between depression, preterm birth, and LBW. Depression had no direct effect on birth outcomes but indirectly affected preterm birth via partner support. Religion had both direct and indirect effects on preterm birth, while occupation and fear of delivery had direct effects. The risk of LBW was 9.44 and 2.19 times higher among preterm births and those who had exposure to tobacco, respectively. Stress coping was indirectly associated, and preterm birth and tobacco exposure were directly associated with LBW. The risk of stillbirth was 3.22 times higher in women with antenatal depression and 73% lower in women with higher coping abilities. Conclusions There was a high incidence of all adverse birth outcomes in Gondar Town. Depression and psychosocial risk factors had important indirect negative effects on risk, while partner support provided a positive indirect effect on the incidence of adverse birth outcomes. Interventions that focus on increasing partner engagement and participation in antenatal support may help reduce adverse birth outcomes by enhancing maternal resilience.
Fibroblast growth factor receptor 2 (FGFR2) in brain neurons and retinal pigment epithelial cells act via stimulation of neuroendocrine L‐type channels (Cav1.3)

In contrast to the fibroblast growth factor receptor 1 (FGFR1), little is known about intracellular signaling of FGFR2. The signaling cascade of FGFR2 was studied using the perforated patch configuration of the patch‐clamp technique in cultured rat retinal pigment epithelial (RPE) cells that express both FGFR1 and FGFR2. Interaction of signaling proteins was studied using immunoprecipitation techniques with membrane proteins from RPE cells and freshly isolated rat brain. When Ba2+ currents through L‐type channels were studied, extracellular application of bFGF (10 ng/ml) led to a shift of the steady‐state activation to more negative values. In 50% of cells, an additional increase in maximal current amplitude was observed. This effect was blocked by the tyrosine kinase inhibitor lavendustin A (10−5 M) but was not influenced by the FGFR1 blocker SU5402 (2×10−5 M) or by the blocker for src‐kinase herbimycin A (10−5 M). Immunoprecipitation of FGFR2 led to coprecipitation of α1D Ca2+ channel subunits and precipitation of α1D subunits led to coprecipitation of FGFR2. Immunoprecipitation of FGFR1 did not result in the coprecipitation with α1D Ca2+ channel subunits. The coprecipitation results were comparable when using brain tissue and RPE cells. The α1D subunit‐specific band were stained with antiphosphotyrosine antibodies. We conclude that FGFR2 acts via a different signaling cascade than FGFR1. This cascade involves an src‐kinase‐independent, close functional interaction of FGFR2 and the α subunit of neuroendocrine L‐type channels. — Rosenthal, R. , Thieme, H. , Strauss, O. Fibroblast growth factor receptor 2 (FGFR2) in brain neurons and retinal pigment epithelial cells act via stimulation of neuroendocrine L‐type channels (Cav1.3). FASEB J. 15, 970–977 (2001)
Improvement of Endothelial Dysfunction of Berberine in Atherosclerotic Mice and Mechanism Exploring through TMT-Based Proteomics

Atherosclerosis is a multifactorial vascular disease triggered by disordered lipid metabolism, characterized by chronic inflammatory injury, and initiated by endothelial dysfunction. Berberine is the main active alkaloid of the herbal medicine Coptidis Rhizoma (Huanglian). Notably, berberine has been shown to have beneficial effects against atherosclerosis. However, the mechanisms of berberine in preventing atherosclerosis are still unclear. This study is aimed at investigating the effects and mechanisms of berberine in protecting the aorta and ameliorating atherosclerosis in apolipoprotein E-deficient (ApoE−/−) mice. Here, we demonstrated that berberine reduced serum lipid levels, antagonized hepatic lipid accumulation, improved intima-media thickening, and alleviated atherosclerotic lesions in ApoE−/− mice fed a western-type diet for 12 weeks. Meanwhile, berberine reduced aortic reactive oxygen species (ROS) generation and reduced the serum levels of malondialdehyde (MDA), oxidized low-density lipoprotein (ox-LDL), and interleukin-6 (IL-6). In aortic ring assay, berberine restored aortic endothelium-dependent vasodilatation in vivo and in vitro. Furthermore, 4,956 proteins were identified by proteomic analysis, and 199 differentially expressed proteins regulated by berberine were found to be involved in many biological pathways, such as mitochondrial dysfunction, fatty acid β-oxidation I, and FXR/RXR activation. Summarily, these data suggested that berberine ameliorates endothelial dysfunction and protects against atherosclerosis, and thus may be a promising therapeutic candidate for atherosclerosis.
Effect of waterpipe tobacco smoke exposure on the development of metabolic syndrome in adult male rats

The prevalence of metabolic syndrome is increased worldwide. Tobacco smoking increases the risk of developing metabolic syndrome. Waterpipe tobacco smoking has become a global trend of tobacco consumption and is as common as cigarette smoking. In this study, the effect of waterpipe tobacco smoke (WTS) on the development of metabolic syndrome in rats was evaluated. Adult Wistar rats were exposed for 19 weeks to either fresh air (control) or WTS for 1 hour daily/ 5 days per week (WTS). Central obesity, systolic blood pressure, lipid profile, glucose hemostasis and levels of leptin and adiponectin were evaluated. The WTS exposure increased body weight, abdominal circumference, systolic blood pressure and fasting glucose compared to control animals (P<0.05), consistent with inducing metabolic syndrome. The retroperitoneal fat, lipid profile and levels of insulin, leptin and adiponectin were not affected by WTS exposure (P>0.05). In conclusion, exposure to WTS has detrimental health effects leading to the development of metabolic syndrome in experimental animals.
Experimental infection of laying hens with Salmonella enterica serovar Gallinarum

Experimental infections were set up in commercial laying birds, comprising a white relatively resistant line and a red susceptible line infecting with Salmonella enterica serovar Gallinarum. The major findings were that in susceptible birds clinical disease occurred in a dose-dependent manner. Faecal excretion occurred in susceptible birds almost up to death but also occurred in the more resistant line and in birds, which were convalescing. Removal of birds, which had died from the disease, from the environment, reduced the resultant mortality/morbidity and may be regarded as a useful measure for control.