Miracle-dz/UniFAR-FTUs huggingface dataset:
On-line incremental routing for interconnect fault tolerance in FPGAs minus the router

In this paper we present a Fault Tolerant (FT) technique for programmable interconnect on Field Programmable Gate Arrays (FPGAs). Our on-line strategy uses incremental reconfiguration capabilities of FPGAs to avoid faults, and the main advantage of our technique is that it does not require a router at the time FT reconfiguration is performed. Our algorithm generates precompiled FT partial configurations that can be downloaded when faults occur. Since the precompiled partial configurations are stored on a net by net basis, the required storage space and the download time is minimal. We have implemented our technique on the ORCA series FPGAs available from Lucent Technologies, and we demonstrate our technique on a FPGA based, on-line Adaptive Computing System (ACS) implemented with the ORCA FPGAs. Our worst case data indicates we can determine an average of seven alternates per signal net and for most circuits up to ten.
La confianza y el compromiso como determinantes de la lealtad: una aplicación a las relaciones de las agencias de viaje minoristas con sus clientes

RESUMEN: La elevada competencia a la que estan sometidas las empresas en la actualidad, hace necesario que estas dispongan de fuentes diferenciadoras que sean capaces de proporcionarles ventajas competitivas sostenibles en el tiempo. Este trabajo realiza un estudio sobre la estrategia del Marketing de Relaciones en el sector turistico, destacando la importancia de la misma en la contribucion al logro de posiciones ventajosas en los mercados. Concretamente, los intercambios comerciales objeto de analisis son los que se producen entre las agencias de viaje minoristas y los consumidores. De esta forma, a traves del planteamiento y contraste de un modelo conceptual en el que se recogen las variables mas relevantes, se observa que la estrategia mencionada se configura como idonea para el ambito seleccionado, permitiendo establecer asi, las conclusiones e implicaciones empresariales pertinentes. Palabras Clave: Marketing de Relaciones, Lealtad, Confianza, Compromiso, Agencias de Viaje.
District Policy and Teachers’ Social Networks

Policy makers increasingly include provisions aimed at fostering professional community as part of reform initiatives. Yet little is known about the impact of policy on teachers’ professional relations in schools. Drawing theoretically from social capital theory and methodologically from qualitative social network analysis, this article explores how district policies influence teachers’ social networks in eight elementary schools in two districts involved in the scale-up of mathematics curriculum. It is argued that policy affects whom teachers seek out for discussion of mathematics instruction but that differences in policy provisions lead to variations in the nature and quality of interactions. Furthermore, school leaders mediate district policy, thereby influencing these patterns of interaction. By uncovering the dynamics by which policy influences teachers’ social networks, this article contributes to understandings of the factors that foster the development of social capital. It also uncovers opportunities for intervention for those designing policy initiatives to support implementation of instructional innovations.
Myristoylation: An Important Protein Modification in the Immune Response

Protein N-myristoylation is a cotranslational lipidic modification specific to the alpha-amino group of an N-terminal glycine residue of many eukaryotic and viral proteins. The ubiquitous eukaryotic enzyme, N-myristoyltransferase, catalyzes the myristoylation process. Precisely, attachment of a myristoyl group increases specific protein–protein interactions leading to subcellular localization of myristoylated proteins with its signaling partners. The birth of the field of myristoylation, a little over three decades ago, has led to the understanding of the significance of protein myristoylation in regulating cellular signaling pathways in several biological processes especially in carcinogenesis and more recently immune function. This review discusses myristoylation as a prerequisite step in initiating many immune cell signaling cascades. In particular, we discuss the hitherto unappreciated implication of myristoylation during myelopoiesis, innate immune response, lymphopoiesis for T cells, and the formation of the immunological synapse. Furthermore, we discuss the role of myristoylation in inducing the virological synapse during human immunodeficiency virus infection as well as its clinical implication. This review aims to summarize existing knowledge in the field and to highlight gaps in our understanding of the role of myristoylation in immune function so as to further investigate into the dynamics of myristoylation-dependent immune regulation.
160 GHz On-Chip Dipole Antenna Structure in Silicon Technology

This paper presents the electromagnetic modelling and design of a on-chip dipole antenna operating in the 160 GHz frequency range. The antenna is fabricated in the 130 nm SiGe HBT with BiCMOS9 backend technologies. The near field measurements are in good agreement with the electromagnetic simulation results obtain using a appropriate model.
Urban object reconstruction using airborne laser elevation image and aerial image

Creating three-dimensional (3-D) models of real urban objects is an important goal in a wide variety of applications. This paper describes a method that utilizes airborne laser elevation images and aerial images for the 3-D reconstruction of urban objects. Our modeling approach uses the vertical geometric pattern analysis of elevation images. These patterns correspond to object contours and, thus, enable the extraction of the object. In addition, to provide realistic textured details, textures are cut from aerial images and mapped onto 3-D models. Our texture-mapping approach can avoid geometry mismatching and enable the automatic registration to determine the most reliable correspondence between projected outlines of 3-D models and contours of real objects shown in aerial images. Edge pairs, which are matched with projected outlines, are detected from aerial images. In order to minimize mismatching, we apply the voting technique based on the generalized Hough transform. Experimental results show that 3-D reconstruction of urban objects is generally successful.
Fatigue in a population-based cohort of patients with inflammatory bowel disease 20 years after diagnosis: The IBSEN study

Abstract Objective: Fatigue is a major concern for patients with ulcerative colitis (UC) and Crohn’s disease (CD), but evidence from population-based studies regarding fatigue in long-standing inflammatory bowel disease (IBD) patients is scarce. Our aims were to assess fatigue scores and the prevalence of chronic fatigue in IBD patients 20 years after diagnosis and to identify variables associated with fatigue in this cohort. Methods: Twenty years after diagnosis, patients from a cohort with incident IBD were invited to a follow-up visit that included a structured interview, a clinical examination, laboratory tests and the Fatigue Questionnaire (FQ). Fatigue scores were obtained, and factors associated with fatigue were assessed via linear and logistic regression analyses. Results: Of the 599 invited patients, 440 (73.5%) completed the FQ. Among those with active disease, we found significantly higher fatigue scores than among those with quiescent disease (fatigue scores: UC 17.1 versus 12.4, p < .001, and CD 17.5 versus 13.3, p < .001). The fatigue scores of those with quiescent disease were comparable with those of the reference population. Chronic fatigue was more frequent among IBD patients than in the reference population. Factors associated with fatigue included self-perceived disease activity, poor sleep quality, anxiety and depression. Conclusion: At 20 years after IBD diagnosis, fatigue scores were higher and chronic fatigue was more frequent among IBD patients with active disease than in the reference population and among those with quiescent IBD. Subjectively perceived disease activity, sleep quality, anxiety and depression were associated with fatigue in IBD patients.
A new barrier for a class of semidefinite problems

We introduce a new barrier function to solve a class of Semidefinite Optimization Problems (SOP) with bounded variables. That class is motivated by some (SOP) as the minimization of the sum of the first few eigenvalues of symmetric matrices and graph partitioning problems. We study the primal-dual central path defined by the new barrier and we show that this path is analytic, bounded and that all cluster points are optimal solutions of the primal-dual pair of problems. Then, using some ideas from semi-analytic geometry we prove its full convergence. Finally, we introduce a new proximal point algorithm for that class of problems and prove its convergence.
Foodservice Quality: Identifying Perception Indicators of Foodservice Quality for Hospitality Students

This study uses an expert perspective to identify indicators of foodservice quality as perceived by hospitality students. A 3-round modified Delphi method and an expert panel comprising culinary arts instructors, master chefs with >10 years of experience, and senior foodservice industry executive managers were used to define and identify these indicators. The developed foodservice quality framework includes 2 categories, the product and customer, which comprise 57 indicators in 6 dimensions. The results of this study provide a clear direction for further studies and applications for hospitality professionals, educators, and students.
Gpd1 and Gpd2 Fine-Tuning for Sustainable Reduction of Glycerol Formation in Saccharomyces cerevisiae

ABSTRACT Gpd1 and Gpd2 are the two isoforms of glycerol 3-phosphate dehydrogenase (GPDH), which is the rate-controlling enzyme of glycerol formation in Saccharomyces cerevisiae. The two isoenzymes play crucial roles in osmoregulation and redox balancing. Past approaches to increase ethanol yield at the cost of reduced glycerol yield have most often been based on deletion of either one or two isogenes (GPD1 and GPD2). While single deletions of GPD1 or GPD2 reduced glycerol formation only slightly, the gpd1Δ gpd2Δ double deletion strain produced zero glycerol but showed an osmosensitive phenotype and abolished anaerobic growth. Our current approach has sought to generate “intermediate” phenotypes by reducing both isoenzyme activities without abolishing them. To this end, the GPD1 promoter was replaced in a gpd2Δ background by two lower-strength TEF1 promoter mutants. In the same manner, the activity of the GPD2 promoter was reduced in a gpd1Δ background. The resulting strains were crossed to obtain different combinations of residual GPD1 and GPD2 expression levels. Among our engineered strains we identified four candidates showing improved ethanol yields compared to the wild type. In contrast to a gpd1Δ gpd2Δ double-deletion strain, these strains were able to completely ferment the sugars under quasi-anaerobic conditions in both minimal medium and during simultaneous saccharification and fermentation (SSF) of liquefied wheat mash (wheat liquefact). This result implies that our strains can tolerate the ethanol concentration at the end of the wheat liquefact SSF (up to 90 g liter−1). Moreover, a few of these strains showed no significant reduction in osmotic stress tolerance compared to the wild type.
Systematic reviews and meta-analyses of preclinical studies: Publication bias in laboratory animal experiments

In 2006, Peters et al. identified 86 systematic reviews (SRs) of laboratory animal experiments (LAEs). They found 46 LAE meta-analyses (MAs), often of poor quality. Six of these 46 MAs tried to assess publication bias. Publication bias is the phenomenon of an experiment's results determining its likelihood of publication, often over-representing positive findings. As such, publication bias is the Achilles heel of any SR. Since researchers increasingly become aware of the fact that SRs directly support the ‘three Rs’, we expect the number of SRs of LAEs will sharply increase. Therefore, it is useful to see how publication bias is dealt with. Our objective was to identify all SRs and MAs of LAEs where the purpose was to inform human health published between July 2005 and 2010 with special attention to MAs’ quality features and publication bias. We systematically searched Medline, Embase, Toxline and ScienceDirect from July 2005 to 2010, updating Peters’ review. LAEs not directly informing human health or concerning fundamental biology were excluded. We found 2780 references of which 163 met the inclusion criteria: 158 SRs, of which 30 performed an MA, and five MAs without an SR. The number of SRs roughly doubled every three years since 1997. The number of MAs roughly doubled every five years since 1999. Compared with before July 2005, more MAs were preceded by SR and reported on (quality) features of included studies and heterogeneity. A statistically significant proportion of MAs considered publication bias (26/35) and tried to formally assess it (21 /35).
Efficacy of Silybum Marianum Seeds in Ameliorating the Toxic Effects of Aflatoxin B1 in Broilers

Background: This study aims to evaluate the efficacy of silybum marianum seeds (SMSs) on blood biochemical profile of broiler chickens contaminated with Aflatoxin B1 (AFB1). Methods: Combinations of three levels of AFB1 (0, 250 and 500 ppb) with three levels of SMSs (0, 0.5, and 1.0 %) were incorporated into the basal diet (corn and soybean meal). The effect of nine experimental treatments was assessed using 216 One-d-old Ross 308 male broiler chicks in a complete randomized design based on factorial design with 4 replicates of six birds. The individual effects of dietary AFB1 and SMSs on serum biochemistry factors and liver enzymes were evaluated at 35 days of age. Statistical package SAS (9.1) was used to perform the analysis. Results: The main effects of uric acid, glucose, total bilirubin and liver enzymes (such as; aspartate amino-transferase (AST), alanine amino-transaminase (ALT) and γ-glutamyl transferase (GGT)) in groups received different levels of AFB1 significantly increased (P<0.01). In contrast, albumin, direct bilirubin, calcium, and phosphorus significantly decreased (P<0.05). However, the SMSs supplemented diets significantly decreased uric acid, glucose, AST and GGT enzymes compare to control group (P<0.01). Conclusion: SMSs might prevent the adverse effects of AFB1 in contaminated food and improve
Expression of heterologous human apolipoprotein E by J774 macrophages enhances cholesterol efflux to HDL3.

Expression of apolipoprotein (apo) E by macrophages is tightly regulated by cellular cholesterol content. We have investigated a potential modulating role for apoE on macrophage cholesterol homeostasis by stably transfecting the J774 macrophage, which does not express its endogenous apoE gene, with a human apoE cDNA expression vector and comparing cholesterol homeostasis in this cell line with that of a control line transfected with the neomycin resistance construct only. Incubation in serum-free medium after cholesterol loading produced no difference in cellular cholesterol content between apoE secreting and non-secreting J774 cells. Similarly, in serum-free medium there was no difference in the amount of radiolabeled cholesterol effluxed. Addition of cAMP or S58035 to cholesterol-loaded J774 cells did enhance efflux of radiolabeled cholesterol from apoE secreting compared to non-secreting macrophages but did not detectably alter cellular free cholesterol or cholesteryl ester mass. Incubation with HDL3 alone, however, significantly decreased macrophage cholesteryl ester mass compared to a 24-h incubation in serum-free medium from 10.5 +/- 3.9 to 3.2 +/- 2.0 (P < 0.01) in apoE-secreting J774 cells. During a 24-h incubation in HDL3, cholesteryl ester fell from 6.4 +/- 2.4 to 0.8 +/- 0.7 (delta = 5.6 micrograms/mg) in apoE-secreting cells and from 9.3 +/- 2.2 to 7.7 +/- micrograms/mg (delta = 1.6 micrograms/mg) in non-secreting cells (P < 0.005 apoE-secreting vs. non-secreting cells). (ABSTRACT TRUNCATED AT 250 WORDS)
Investigation of the Risk Factors for Leukoaraiosis (LA)

Leukoaraiosis (LA) describes abnormal changes in the cerebral white matter frequently seen on CT and MRI in older adults. Its appearance indicates mild brain injury, and it is often regarded as a mark of senile dementia. Through the analysis of related risk factors of 6000 patients with LA diagnosed by cranial MRI in our department, we found that age, cerebral infarction, lacunar infarction, history of brain hemorrhage, and increased triglycerides were risk factors for LA, and the relative risk odds ratio values were 2.135 (95% confidence interval [CI] = 1.874-2.501), 3.330 (95% CI = 1.922-3.997), 3.412 (95% CI = 2.986-3.512), 3.611 (95% CI = 2.054-9.147), and 1.457 (95% CI = 1.058-1.769), respectively. Through the identification of the risk factors for LA and effective interventions, the occurrence of dementia, stroke, and premature death may be effectively prevented.
T and L slotted patch antenna for future mobile and wireless communication

This paper, design a T and L slotted microstrip patch antenna used for future mobile and wireless communication. The size of antenna is 10×10mm2 with thickness 1.6mm and the dielectric constant of substrate 4.4 with FR-4 epoxy material is used. This antenna is fed by the 50ohms microstrip line feed and T and L slotted radiating patch is used. Simulation of T and L slotted microstrip patch antenna used by the CST software. The design and simulation results are analyzed the return loss, VSWR, surface current distribution, farfield radiation pattern and farfield gain. This antenna obtained the return loss −47.53dB and −35.73dB which cover the26.43GHz to 29.37 GHz and 26.04GHz to 29.94 GHz band. The farfield gain have a 6.4dB and 5.57dB. This antenna operates the 28GHz frequency band for 5G communication is presented.
Going for the Gold

Two studies examined how Olympic performance is explained in American and Japanese contexts. Study 1, an analysis of media coverage of the 2000 and 2002 Olympics, shows that in both Japanese and American contexts, performance is construed mainly in terms of the actions of persons. However, Japanese and American accounts differ in their explanations of the nature and source of intentional agency, that is, in their models of agency. In Japanese contexts, agency is construed as conjoint and simultaneously implicates athletes' personal attributes (both positive and negative), background, and social and emotional experience. In American contexts, agency is construed as disjoint, separate from athletes' background or social and emotional experience; performance is explained primarily through positive personal characteristics and features of the competition. Study 2, in which participants chose information to be included in an athlete's description, confirms these findings. Differences in the construction of agency are reflected in and fostered by common cultural products (e.g., television accounts).
Predominant type‐2 response in infants with respiratory syncytial virus (RSV) infection demonstrated by cytokine flow cytometry

Acute RSV infection in infancy may produce some asthma‐like symptoms and may be followed by a recurrent wheeze later in childhood. It has been proposed that RSV infection stimulates type‐2 cytokine responses, resembling those found in atopy and asthma. Peripheral blood cells were obtained from RSV‐infected infants (n = 30) and healthy controls (n = 10). After in vitro restimulation of the cells, intracellular IL‐4 and interferon‐gamma (IFN‐γ) were measured by flow cytometry. The cells from RSV‐infected infants produced more IL‐4 and less IFN‐γ than those from healthy controls. IL‐4 production was more frequent in CD8 than in CD4 cells, and the bias toward IL‐4 production was greatest in infants with mild infections, whereas IFN‐γ production increased with disease severity. Our conclusions are that RSV infection is associated with IL‐4 production in peripheral T cells, and that peripheral blood in infants with severe disease may be depleted of cytokine‐producing cells.
Using Word Embeddings for Search in Linked Data with Ontodia

Ontodia is an open-source diagramming and visual exploration tool for linked data and ontologies. Here, we present an extension of the Ontodia data query functionalities. We evaluate diﬀerent types and conﬁgurations of word embeddings for improving recall and ﬂexibil-ity of the Ontodia natural language interface. The demonstration will focus especially on the new query functionalities, where Ontodia will be applied to Wikidata as underlying dataset.
An Image Fusion System for Estimating the Therapeutic Effects of Radiofrequency Ablation on Hepatocellular Carcinoma

Abstract Background During ultrasound-guided radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC), high echoic areas due to RFA-induced microbubbles can help calculate the extent of ablation. However, these areas also decrease visualization of target tumors, making it difficult to assess whether they completely cover the tumors. To estimate the effects of RFA more precisely, we used an image fusion system (IFS). Patients and methods We enrolled patients with a single HCC who received RFA with or without the IFS. In the IFS group, we drew a spherical marker along the contour of a target tumor on reference images immediately after administering RFA so that the synchronized spherical marker represented the contour of the target tumor on real-time ultrasound images. When the high echoic area completely covered the marker, we considered the ablation to be complete. We compared outcomes between the IFS and control groups. Results We enrolled 25 patients and 20 controls, and the baseline characteristics were similar between the two groups. The complete ablation rates during the first RFA session were significantly higher in the IFS group compared with those in the control group (88.0% vs. 60.0%, P = 0.041). The number of RFA sessions was significantly smaller in the IFS group compared with that in the control group (1.1 ± 0.3 vs. 1.5 ± 0.7, P = 0.016). Conclusions The study suggested that the IFS enables a more precise estimation of the effects of RFA on HCC, contributing to enhanced treatment efficacy and minimized patient burden.
Slide Seminar-Infectious Lung Diseases Case 1

Case history: A 69 years old patient was readmitted to the hospital after resection of the left upper lobe of the lung 4 months before because of SqCLC (T1 N0 R0 M0 L1 V1). The patient was ex-smoker (50 py). a year before the diagnosis of lung cancer. He had been farmer and locksmith. At readmission the patient suffered from dyspnoe, chest pain and weight loss. He had medication against cardial insufficiency and corticosteroids (Dexamethason, 8 mg). There was candidiasis of the oral mucosa. Vital capacity was reduced. Chest x-ray revealed ground glass opacity of the left residual lung with destroyed areas (abscess) in the upper part and pleural effusion was seen basally. In the bronchial washing ESBL-producing E. coli was found and treated according to resistance test. Bronchoscopy revealed irregularities of the bronchial mucosa of the residual left-upper-lobe bronchus, suspicious for recurrent cancer. Endobronchial biopsies from this area were taken (snap-shots). PET scan showed strong enhancement in the left lung, so 9 days after bronchoscopy a transthoracic biopsy was taken.