Miracle-dz/UniFAR-FTUs huggingface dataset:
Comorbidity of Bipolar and Personality Disorder

Objective: The aims of this study were to determine the prevalence of personality disorder in a sample of patients with well-documented bipolar disorder, and to assess the effects of cormorbidity. Method: The sample (n = 42) was drawn from patients currently case-managed within a community treatment program who fully met DSM-IV criteria for bipolar I disorder. The International Personality Disorder Examination, a structured interview, was used to diagnose personality disorder. The Brief Symptom Inventory assessed overall levels of psychological symptoms. Results: Seven of the 13 men (55%) in the sample had 10 personality disorder diagnoses and 12 of the 29 women (41%) had 28 diagnoses, an overall prevalence of 45%. Hospital admission rates and all measures of psychological symptoms and impairment were significantly elevated in the comorbid group, who found medication significantly less helpful. Conclusions: Comorbid personality disorder was common in the sample studied, which was representative of Australian patients treated in public community psychiatry programs. However, only three (7%) had a personality disorder diagnosis recorded in their case notes, reflecting clinicians' reluctance to apply what is widely viewed as a pejorative and therapeutically nihilistic label. New treatments for personality disorder have proven effective within both public and private psychiatric settings, so that underdiagnosis represents undertreatment. The findings suggest that clinicians should be more vigilant for comorbid personality and bipolar disorder, and less reluctant to diagnose it.
Safety and Efficacy of a New Parenteral Lipid Emulsion (SMOFlipid) in Surgical Patients: A Randomized, Double-Blind, Multicenter Study

Background/Aims: A new lipid emulsion based on soybean oil, medium chain triglycerides, olive oil and fish oil (SMOFlipid) was tested for safety, tolerance, metabolic and clinical efficacy in surgical patients. Methods: In a prospective, double-blind European multicenter study, postoperative patients (elective abdominal or thoracic surgery) were randomized to receive isonitrogenous, isoenergetic (30–35 kcal/kg) total parenteral nutrition over 5 postoperative days including either SMOFlipid® 20% or standard soybean oil emulsion (Lipovenoes® 20%) as lipid source (1.5 g kg–1 day–1). Metabolic efficacy measurements included serum levels of triglycerides (AUC), phospholipids, and total cholesterol. Safety/tolerance parameters were: hematology; clinical chemistry; coagulation profile; clinical course (arterial blood pressure, heart rate, body temperature), and documentation of adverse events. Clinical efficacy was monitored by length of hospital stay and mortality. Results: The 2 groups (per-protocol population: SMOFlipid n = 99, and Lipovenoes n = 100) were similar with respect to demographic characteristics and types of surgical intervention. Concentrations of serum triglycerides, phospholipids, and total cholesterol were comparable in both groups and within the expected ranges. Laboratory and clinical parameters were not different. A trend towards a reduced length of hospital stay was observed with SMOFlipid (15.7 ± 6.3 vs. 17.8 ± 13.2 days). Conclusions: SMOFlipid is clinically safe and well tolerated in postoperative patients. There are indications that SMOFlipid may be associated with a better liver tolerance and a shorter length of hospitalization.
Boundary lubrication of joints: Characterization of surface-active phospholipids found on retrieved implants

Background The identity of the vital active ingredient within synovial fluid (SF)—to which we owe the near frictionless performance of diarthrodial joints—has been the quest of researchers for many years. Initially, hyaluronic acid (HA) was thought to be the lubricant, but it has been shown not to possess the load-bearing ability required within the physiological joint. The glycoprotein fraction of synovial fluid (lubricin) has been shown to have the same lubricating ability as synovial fluid. All or part of this is thought to be due to the sur-face-active phospholipids (SAPLs) present in lubricin. We characterized the SAPLs adsorbed on the surface of retrieved prostheses which have been implicated as the boundary lubricant. Material and methods Rinsing fluids collected from the bearing surfaces of 40 prostheses removed from hip and knee revision operations were analyzed using highperformance liquid chromatography (HPLC). Results SAPLs were detected on all retrieved implants. During the study, 8 different species of phosphatidylcholines were identified. We also determined the relative concentration of each species, which suggested that the unsaturated SAPL species predominate. Interpretation It is of value to know the identity of the lubricating constituents of SF, not only for the future development of artificial joints, but also in developing cures for several disease processes in which lubrication plays a role.
Characterization, Concentration and Utilization of Sweet and Acid Whey

Normal acid and sweet whey samples were collected from six national dairy plants located in Amman city. They were characterized physico-chemically. The whey was concentrated using vacuum scraper concentrator; the concentration process was optimized with regard to several variables. The concentrated whey either acid or sweet were obtained and evaluated organoleptically with regard to color, flavor and consistency. Accordingly, the optimum concentration treatment was chosen, characterized physico- chemically and used for further research work. The obtained results revealed that the Concentrated Acid Whey (CAW) had more dry matter (68.98%), acidity (4.95%) and salt (14.56%) compared with the Concentrated Sweet Whey (CSW). On the other side, CSW had more lactose (36.40%) and protein (8.25%) compared to CAW. CAW had a better stability or shelf life than that of CSW due to its lower water activity (0.35). The concentrated whey was relatively rich in many minerals and trace elements i.e Na, K, Ca and Mg. Consumption of 50 g of CAW when used as a sugar replacer in bakery and confectionery items will contribute 114, 34, 25, 22, 20 and 18% of the recommended daily intakes of Na, Zn, Cu, Ca, Mg and K respectively. The mineral composition data as well as the sensory evaluation results reflected the unlimited benefits that can be achieved by concentrating acid and sweet whey and there incorporating in formulating some bakery and confectionery items. The addition of acid whey solids to the three studied items i.e cookies, spongy cake and bread improved their quality parameters specially flavor, color and texture.
Regulation of RNA degradation in cultured rat hepatocytes: Effects of specific amino acids and insulin

The regulation of RNA degradation by specific amino acids and insulin was investigated in cultured rat hepatocytes from fed rats previously injected in vivo with [6‐14C]orotic acid. The effects of three groups of amino acids were compared to those of a complete amino acid mixture. The first one consisted of the eight amino acids (leucine, proline, glutamine, histidine, phenylalanine, tyrosine, methionine, tryptophan) previously found to be particularly effective in the control of proteolysis. The two other groups were defined from our study with single additions of amino acids, one consisting of proline, asparagine, glutamine, alanine, phenylalanine, and leucine and the other including the latter group with serine, histidine, and tyrosine. The results showed that these three groups were able to strongly inhibit deprivation‐induced RNA breakdown at one and ten times normal plasma concentrations but to a lower extent than the complete amino acid mixture. Six amino acids (proline, asparagine, glutamine, alanine, phenylalanine, leucine) inhibited individually RNA degradation by more than 20%. However, the deletions of proline, asparagine, glutamine, or alanine from the group of these six amino acids were not followed by a loss of inhibitory effect. On the contrary, an important loss of inhibition was observed when leucine and phenylalanine were deleted. Furthermore, only these two amino acids exhibited an additive inhibitory effect. Thus leucine and phenylalanine could be considered as important inhibitors of RNA breakdown in cultured rat hepatocytes. Finally, insulin which had no significant effect on RNA degradation in the absence of amino acids, was able to potentiate the inhibitory effect of different amino acid groups. © 1993 Wiley‐Liss, Inc.
Is it a SmartNIC or a Key-Value Store?: Both!

[1] Sheng Li et al.2015. Architecting to achieve a billion requests per second through-put on a single key-value store server platform. In ACM SIGARCH Comput Architect News. ACM. [2] Michaela Blott et al.2013. Achieving 10Gbps Line-rate Key-value Stores withFPGAs. InHotCloud [3] Giuseppe Bianchi et al.2014. OpenState: programming platform-independent stateful openflow applications inside the switch. ACM SIGCOMM CCR. [4]Masoud Moshref et al.2014. Flow-level state transition as a new switch primitivefor SDN. In ACM SIGCOMM HotSDN. [5]Berk Atikoglu et al.2012. Workload analysis of a large-scale key-value store. In ACM SIGMETRICS Performance Eval. Rev. Motivation PoC Implementation
Évolution de l'acidité et de la disponibilité en azote des sols forestiers français au cours du 20ème siècle

Les activites humaines ont, depuis plus d'une centaine d'annees, influence de plus en plus fortement les cycles geochimiques controlant les niveaux d'acidite et de disponibilite en azote dans la nature. Les depots acides et azotes conduisent a une modification des conditions du milieu et notamment a des changements sensibles de la composition des communautes d'especes vegetales. L'objectif de cette these est de retracer l'evolution spatio-temporelle de l'acidite et de la disponibilite en azote des sols forestiers francais au cours du 20eme siecle a partir du caractere bio-indicateur de la flore, a l'echelle locale ainsi globale. L'utilisation de la flore comme bio-indicateur vise a pallier l'absence de donnees de mesures directes des conditions edaphiques et des depots atmospheriques acides et azotes couvrant une large emprise spatio-temporelle. Premierement, les variations de pH (indicateur d'acidite) et C:N (indicateur de disponibilite en azote) bio-indiquees ont ete calculees a partir d'environ 100 000 releves floristiques temporaires realises dans toute la France de 1910 a 2010. Elles ont ete analysees par une methode novatrice de comparaison spatio-temporelle, en differenciant les zones forestieres sur substrat acide et non-acide ainsi que les forets de coniferes et de feuillus. Dans un second temps, nous avons analyse les changements des conditions edaphiques entre 1972 et 2011 a l'echelle de la foret de Villey-Le-Sec, et ceux de la flore qu'ils induisent en lien avec d'autres evolutions environnementales, toujours a partir du caractere bio-indicateur de la flore.A l'echelle globale, nous avons observe une acidification des forets francaises en milieu acide (-0.34 unites du pH en moyenne) et milieu non-acide (-0.19 unites du pH en moyenne), respectivement, jusqu'en 1984 et 1997. Nous avons ensuite mis en evidence, pour la premiere fois a notre connaissance, un arret dans l'acidification des sols forestiers et meme une diminution de l'acidite sur substrat non-acide ainsi que un decalage temporel entre l'acidification des zones acides et non-acides. Cette evolution apparait tout a fait coherente avec celle connue des depots atmospheriques acidifiants en France depuis le debut du 20eme siecle. Spatialement, nous confirmons la tendance temporelle, montrons une evolution regionalisee de l'acidification principalement sur substrat non-acide et soulignons la grande variabilite spatiale des changements de pH des sols forestiers. Concernant l'evolution de la disponibilite en azote, nous observons une diminution non attendue de celle-ci jusqu'en 1984 et 1997, respectivement, dans les forets de coniferes (+0.79 unites de C:N en moyenne) et de feuillus (+0.74 unites de C:N en moyenne). Une tendance a l'eutrophisation des sols forestiers a ensuite ete observee dans les forets de coniferes et de feuillus a partir de 1997 (-0.10 et -0.16 unites de C:N en moyenne, respectivement). Cette evolution apparait decalee par rapport a celle des depots azotes en France. [. ] Suite et fin du resume dans la these.
Predictors of Older Adults’ Capacity for Medication Management in a Self-Medication Program

Objectives: The aim of this project was to identify variables that predicted older adults’ ability to manage medications. Methods: The study used a retrospective cohort design and was set in a self-medication program within a rehabilitation hospital. A random sample of charts from 301 participants in the self-medication program was reviewed. Results: Logistic regression models accounted for 26.7% and 55.8% of the variance in the probability of making one or more self-medication errors during the initial and final weeks of the program, respectively. The importance of cognition in predicting medication management capacity was seen in bivariate and multivariate analyses and through a number of interactions with other predictors. Statistically significant predictors in one or both analyses included medication regimen complexity, Mini-Mental State Exam (MMSE) score, duration of institutionalization, depression, and interactions between (a) medication regimen complexity and MMSE score and (b) ability to cook and MMSE score. Discussion: The direct effects of cognition and medication regimen complexity were important predictors of medication management capacity.
Decentralized Detection and Mitigation of Sinkhole Attacks in Wireless Sensor Networks based on Network Density Estimation Technique

The modern Wireless Sensor Networks (WSN) has wider perspective implication in various domains but the frequency of network threats also grown with the technology. Apart from other threats, the traffic orient sinkhole attack makes the remarkable difference in quality of service in any service orient architecture. By learning traffic, the sinkhole nodes reduce the scalability and performance of the whole network. Identifying the presence of sinkhole attacking nodes and mitigating them is the great deal of research in wireless sensor network; we motivated with the challenge and propose a novel decentralized sinkhole detection mechanism using Network Estimation Technique (NDE). The NDE technique is performed by every node of the network where every node maintains the neighbor table to store the neighbor details. Also the node monitors and computes the average traffic occurred in its own interface at each time window. The own traffic has been estimated based on number of packets being received at each time domain, whether it belongs to the same or others. With the computed traffic, the node collects the information about the neighbors of neighbor nodes. Using all these NDE techniques estimate the network density and identifies the presence of malicious node in the region. Identified malicious node information is distributed to the neighbor nodes, so that the malicious node will be ignored at next transmissions. This method reduces the overhead of collecting snapshots and routes. This method increases the network throughput by increasing the Best Effort (BE) traffic.
Circadian variation in plasma 5‐hydroxyindoleacetic acid level during and after alcohol withdrawal: phase advances in alcoholic patients compared with normal subjects

Alcohol withdrawal symptoms in 19 male alcoholics were objectively evaluated and classified and circadian variation in their plasma 5‐hydroxyindoleacetic acid (5‐HIAA) concentrations was determined at 3 different intervals after cessation of drinking. Circadian variations in plasma 5‐HIAA level exhibited phase advances in alcoholic patients compared with normal controls and were different depending on the severity of alcohol withdrawal symptoms. Plasma 5‐HIAA in patients with delirium tremens showed significantly higher levels during the abstention period, possibly suggesting peculiarity in their serotonergic metabolism.
Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

ABSTRACT The retinoblastoma protein (pRb) acts to constrain the G1-S transition in mammalian cells. Phosphorylation of pRb in G1 inactivates its growth-inhibitory function, allowing for cell cycle progression. Although several cyclins and associated cyclin-dependent kinases (cdks) have been implicated in pRb phosphorylation, the precise mechanism by which pRb is phosphorylated in vivo remains unclear. By inhibiting selectively either cdk4/6 or cdk2, we show that endogenous D-type cyclins, acting with cdk4/6, are able to phosphorylate pRb only partially, a process that is likely to be completed by cyclin E-cdk2 complexes. Furthermore, cyclin E-cdk2 is unable to phosphorylate pRb in the absence of prior phosphorylation by cyclin D-cdk4/6 complexes. Complete phosphorylation of pRb, inactivation of E2F binding, and activation of E2F transcription occur only after sequential action of at least two distinct G1cyclin kinase complexes.
Risk and reliability worth assessment of power systems under corrective control

This paper focuses on the impact of corrective control on the operating risk of power systems. The risk level is assessed through the Expected Energy Not Served (EENS) and the Expected Interruption Cost (EIC). The goal is to find the most cost effective option for enhancing the ability of the transmission system to deliver projected demand by comparing various corrective control scenarios with traditional reinforcement schemes. This is undertaken for different levels of corrective control and reliability profiles of control devices. In this paper the Static Var Compensator (SVC) is used as the primary corrective control device. A simple method for optimal placement of the SVCs around the network is proposed. Annualized risk indices are calculated through Chronological Monte Carlo Simulation (CMCS). Reliability worth assessment is then carried out based on net present value (NPV) which accounts for the Expected Interruption Cost as well as investment and operating costs. The scenario with the minimum overall cost is selected as the best one. The methodology is tested on the RBTS 6 bus composite system.
A Novel Class of Generative Neural Networks

In this research paper, along the lines of the goal of constructive neural networks, a novel neural network, as an alternative to Multi Layer Perceptron is proposed. Based on the idea of one step associative memories, a novel bidirectional one step associative memory is proposed. Also, an interconnected array of associative memories is proposed. Along the lines of logical basis of Hopfield neural network, two linear/non-linear dynamical systems are proposed.
The Stratus architecture

An overview is given of the architecture of the Stratus fault-tolerant computer systems, which were the first to use hardware alone to provide fault tolerance in the commercial marketplace. The power subsystem, system boards, and off-board I/O interface buses are examined in some detail. Recovery scenarios and the Stratus service approach are described. <<ETX>>
Downregulation of integrin α v β 3 expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense uPAR and sense p 16 genes

Division of Cancer Biology, Departments of Biomedical Therapeutic Sciences (S.S.L., N.C., N.Y., C.S., G S.M., J.S.R), Neuropathology (M.G.), Neurosurgery (D.H.D., W.C.O., J.S.R) University of Illinois College of Medicine at Peoria, Peoria, IL.61656, Department of Bio-immunotherapy, (B.A) M. D. Anderson Cancer Center Houston TX 77030 and Department of Neurological Surgery (YA, T.T. and T.O), Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
Transmembrane signalling by a hybrid protein: communication from the domain of chemoreceptor Trg that recognizes sugar-binding proteins to the kinase/phosphatase domain of osmosensor EnvZ

Chemoreceptor Trg and osmosensor EnvZ of Escherichia coli share a common transmembrane organization but have essentially unrelated primary structures. We created a hybrid gene coding for a protein in which Trg contributed its periplasmic and transmembrane domains as well as a short cytoplasmic segment and EnvZ contributed its cytoplasmic kinase/phosphatase domain. Trz1 transduced recognition of sugar-occupied, ribose-binding protein by its periplasmic domain into activation of its cytoplasmic kinase/phosphatase domain as assessed in vivo by using an ompC-lacZ fusion gene. Functional coupling of sugar-binding protein recognition to kinase/phosphatase activity indicates shared features of intramolecular signalling in the two parent proteins. In combination with previous documentation of transduction of aspartate recognition by an analogous fusion protein created from chemoreceptor Tar and EnvZ, the data indicate a common mechanism of transmembrane signal transduction by chemoreceptors and EnvZ. Signalling through the fusion proteins implies functional interaction between heterologous domains, but the minimal sequence identity among relevant segments of EnvZ, Tar, and Trg indicates that the link does not require extensive, specific interactions among side chains. The few positions of identity in those three sequences cluster in transmembrane segment 1 and the short chemoreceptor sequence in the cytoplasmic part of the hybrid proteins. These regions may be particularly important in physical and functional coupling. The specific cellular conditions necessary to observe ligand-dependent activation of Trz1 can be understood in the context of the importance of phosphatase control in EnvZ signalling and limitations on maximal receptor occupancy in binding protein-mediated recognition.
Observations of a Protistan Disease Similar to QPX in Mercenaria mercenaria (Hard Clams) from the Coast of Massachusetts

During the summer and fall of 1995, in clam aquaculture leases at two locations on the coast of Massachusetts, significant mortalities were observed to occur primarily in 1½- to 2-year old hard clams (Mercenaria mercenaria, quahog) planted in the leases. Examination of hard clams from those leases suggested a parasite similar to QPX (Quahog Parasite Unknown), as described by Whyte, S. K. , Cawthorn, R. J., and McGladdery, S. E. (1994, Can. Dis. Ag. Org. 19, 129-136), was responsible for the poor condition of affected clams and the resulting high mortality. In clam tissues, the QPX-like parasite formed thalli surrounded by a mucofilamentous net. Larger thalli underwent endosporulation producing sporangia that contained approximately 40 endospores. Rupture of the sporangium released the endospores into the surrounding tissue. Inflammatory response by the clam to infection was chronic, active, and granulomatous. The occurrence both of phagocytic multinucleated giant inflammatory cells and inflammatory encapsulation of parasites were commonly identified as part of the response. Moderately to severely infected clams showed significantly reduced growth and a poorer condition index as compared to uninfected or mildly infected clams. Copyright 1998 Academic Press. Copyright 1998 Academic Press
coancestry: a program for simulating, estimating and analysing relatedness and inbreeding coefficients

The software package coancestry implements seven relatedness estimators and three inbreeding estimators to estimate relatedness and inbreeding coefficients from multilocus genotype data. Two likelihood estimators that allow for inbred individuals and account for genotyping errors are for the first time included in this user‐friendly program for PCs running Windows operating system. A simulation module is built in the program to simulate multilocus genotype data of individuals with a predefined relationship, and to compare the estimators and the simulated relatedness values to facilitate the selection of the best estimator in a particular situation. Bootstrapping and permutations are used to obtain the 95% confidence intervals of each relatedness or inbreeding estimate, and to test the difference in averages between groups.