Miracle-dz/UniFAR-FTUs huggingface dataset:
Creating oral squamous cancer cells: A cellular model of oral–esophageal carcinogenesis

Immortalization and malignant transformation are important steps in tumor development. The ability to induce these processes from normal human epithelial cells with genetic alterations frequently found in the corresponding human cancer would significantly enhance our understanding of tumor development. Alterations in several key intracellular regulatory pathways (the pRB, p53, and mitogenic signaling pathways and the telomere maintenance system) appear to be sufficient for the neoplastic transformation of normal human cells. Nevertheless, in vitro transformation models to date depend on viral oncogenes, most prominently the simian virus 40 early region, to induce immortalization and malignant transformation of normal human epithelial cells. Here, we demonstrate a transformation model creating oral–esophageal cancer cells by using a limited set of genetic alterations frequently observed in the corresponding human cancer. In a stepwise model, cyclin D1 overexpression and p53 inactivation led to immortalization of oral keratinocytes. Additional ectopic epithelial growth factor receptor overexpression followed by c-myc overexpression as well as consecutive reactivation of telomerase induced by epithelial growth factor receptor sufficed to transform oral epithelial cells, truly recapitulating the development of the corresponding human disease.
Legislative Gender Diversity and the Resolution of Civil Conflict

Policy makers and scholars have shown increased interest in gendered approaches to peacemaking, even as evidence of women’s impact on peace processes has remained unclear. In this paper, we explore the influence of gender diversity among decision-making elites on the outcome of ongoing civil conflicts. Specifically, we argue that increased female representation within the national legislature increases the likelihood that a conflict terminates in a negotiated settlement. However, the impact of legislative female representation on conflict termination is conditioned by the power of the legislature vis-à-vis the executive, suggesting that gender diversity exerts a greater impact in states with more authoritative legislatures. We evaluate our hypotheses using data on the manner of conflict termination and the proportion of women in national legislatures between 1945 and 2009. Our results show support for the central argument, suggesting that increasing female representation within legislative bodies increases the likelihood of war termination via negotiated settlement.
The role of HLA antigens in the aetiology of psoriasis.

AIM To investigate the association of the HLA-C allele with psoriasis. Methods Twenty five type I psoriasis patients with 25 healthy controls participated in this study. PCR-SSP was preferred for HLA-C typing. The patients were questioned for age at onset and family history and examined for severity and area of involvement of the disease and presence of articular, nail and scalp involvement. PCRSSP method was preferred for HLA-C typing. Statistical analyses were made using the Chi-square test. Relative risk was assessed to determine the association between disease and HLA antigen. RESULTS The increase prevalence of HLA-Cw6 antigen among type I psoriasis vulgaris patients (p=0.0047) compared with healthy controls was noticed, but not in the prevalence of other HLA-C alleles. Among psoriasis patients, 14 (56%) had a positive family history. Among all patients, eight (32%) had articular symptoms, 19 (76%) had nail involvement, and all subjects had scalp involvement. Onset of disease was 6.7 years earlier in patients with positive family history compared with negative family history. No significant association was found between HLA-C alleles and family history, clinical findings or severity of the disease. CONCLUSION Our findings are consistent with previous studies that have shown association between HLA-Cw6 antigen and early onset of the disease. Clarifying the role of HLA-Cw6 antigen in the etiopathogenesis provides important advances in gene therapy for psoriasis.
Acupoint electrical stimulation reduces acute postoperative pain in surgical patients with patient-controlled analgesia: a randomized controlled study.

OBJECTIVES The purpose of this study was to evaluate the effect of acupoint electrical stimulation with patient-controlled analgesia (PCA) on reducing acute pain, nausea, and vomiting after surgery for nontraumatic spinal cord injury. METHODS A randomized, controlled, repeated measures research design was used. Ninety-nine patients undergoing lumbar spinal surgery were randomly assigned to one of three groups. Patients in experimental group 1 (EG1) received true acupoint electrical simulation three times, whereas those in experimental group 2 (EG2) received sham acupoint manually. Patients in the control group (CG) received no acupoint intervention. All patients were measured for pain, initial demand for PCA, demand for opiates, opiate dose, vital signs, and postoperative nausea and vomiting (PONV). RESULTS Significant differences were found in postoperative pain, respiratory rate, blood pressure, and opiate doses across time in the three groups with better outcomes observed in EG1 than in EG2. However, no between-group difference was found in initial demand for PCA or in PONV. CONCLUSIONS The study demonstrates that acupoint electrical stimulation improves acute postoperative pain management without adversely affecting vital signs after surgery for nontraumatic spinal injury. More studies are needed to evaluate the effects ofacupoint electrical stimulation on PONV and postoperative pain following other surgical procedures.
Activation of mitogen-activated protein kinase in porcine carotid arteries.

The thin-filament protein h-caldesmon (the high molecular weight isoform of caldesmon) is phosphorylated in resting and contracted porcine carotid arteries. Phosphorylation of h-caldesmon in intact tissue occurs at sites that are covalently modified by mitogen-activated protein kinase (MAPK) in vitro. In this study, we have evaluated MAPK activation in arteries in response to mechanical load and pharmacological stimulation. MAPK was extracted from resting and stimulated porcine carotid arteries and then partially purified by anion-exchange fast-performance liquid chromatography. MAPK activity was separated into two peaks corresponding to the tyrosine-phosphorylated 42- and 44-kD isoforms of MAPK (p42MAPK and p44MAPK, respectively). Of the total MAPK activity, 42% was associated with p42MAPK, and 58% was associated with p44MAPK, this percentage was not altered by stimulation of the muscles with either KCl (110 mmol/L) or phorbol 12,13-dibutyrate (PDBu, 1 mumol/L). Both p42MAPK and p44MAPK, purified from porcine carotid arteries, phosphorylated h-caldesmon at the same sites and to levels approaching or > 1 mol phosphate per mole protein. In unloaded muscle strips, MAPK activity was 39 pmol.min-1.mg protein-1 when assayed with the peptide substrate APRTPG-GRR. MAPK activity increased in response to incremental mechanical loading to a maximum of 99 pmol.min-1.mg protein-1 at 16 x 10(3) N/m2. MAPK activity could be further increased in loaded muscles by pharmacological stimulation. With KCl stimulation, MAPK activities rose to a peak of 205 pmol.min-1.mg protein-1 at 10 minutes and then declined to basal values at 30 and 60 minutes. (ABSTRACT TRUNCATED AT 250 WORDS)
On implementation of link adaption in OFDM wireless networks

The popularity of wireless networks has soared in recent years. The wireless channel, along with its many benefits, poses a host of challenges for system designers, due to its time-varying and frequency selective behavior. Orthogonal frequency division multiplexing (OFDM) addresses some of these challenges at the physical layer. In this paper, we discuss various issues in a practical implementation of an OFDM based system which supports adaptive modulation. A novel blind scheme for detecting inactive carriers, resulting from water-filling or other adaptive modulation, is proposed and investigated. Extensive simulation of the detection scheme, in an IEEE 802.11a framework, shows it to be robust against changes in code rate, data modulation and water-level. Backward compatibility of the new scheme with existing devices is also discussed and detection of new devices at the system level is suggested and described. Overall, the work in this paper forms the basis for a cross-layer approach to the optimization of wireless networks, in which the physical, link and network layers are adapted to system parameters such as buffer state, traffic statistics, and channel conditions
Correlation between fetal sex and human chorionic gonadotropin in peripheralmaternal blood and amniotic fluid in second and third trimester normal pregnancies

BACKGROUND To study the correlation between fetal sex and human chorionic gonadotropin (hCG) in maternal blood and amniotic fluid. METHOD AND MATERIAL One hundred and thirty uncomplicated pregnancies, 82 of whom were at sixteen and 48 at thirty-five weeks of gestation. RESULTS The hCG levels were significantly higher in maternal serum than in amniotic fluid. At 16 weeks there were no sex-related differences in the hCG levels, either in maternal blood or in amniotic fluid. At 35 weeks the hCG levels in maternal blood were significantly higher in pregnancies with female fetuses than in those carrying male fetuses (p<0.004), while in amniotic fluid the hCG levels tended to be slightly higher in the female group than in the male. In pregnancies with female fetuses the hCG levels in maternal blood were significantly higher at 35 than at 16 weeks (p<0.02), while in pregnancies with male fetuses the levels were highest at 16 weeks. For both sexes the hCG levels in amniotic fluid were significantly higher at 16 than at 35 weeks of pregnancy (p<0.001). Whereas a significant correlation between hCG levels in maternal blood and amniotic fluid was seen at 16 weeks of gestation for both sexes (p<0.01 and R value 0.45 for males and 0.41 for females), no correlation was observed at 35 weeks. CONCLUSION This study shows a significant correlation between hCG and fetal sex at third trimester of gestation only, possibly caused by a gender factor and a shift in synthesis and/or in metabolism of hCG from the second to the third trimester.
Evaluation of survival distribution predictions with discrimination measures

In this paper we consider how to evaluate survival distribution predictions with measures of discrimination. This is a non-trivial problem as discrimination measures are the most commonly used in survival analysis and yet there is no clear method to derive a risk prediction from a distribution prediction. We survey methods proposed in literature and software and consider their respective advantages and disadvantages. Whilst distributions are frequently evaluated by discrimination measures, we find that the method for doing so is rarely described in the literature and often leads to unfair comparisons. We find that the most robust method of reducing a distribution to a risk is to sum over the predicted cumulative hazard. We recommend that machine learning survival analysis software implements clear transformations between distribution and risk predictions in order to allow more transparent and accessible model evaluation. ∗raphaelsonabend@gmail.com 1 ar X iv :2 11 2. 04 82 8v 1 [ st at . M L ] 9 D ec 2 02 1
The role of weak ties in enhancing knowledge work

The purpose of this research paper is to explore the collaboration in knowledge worker's performance from the organizational perspective and decompose most relevant contributing factors. A systematic literature review based on Fink's model [1] was conducted, 22 key journal articles were selected for further analysis. This research sheds light on the use of weak ties in knowledge workers' related tasks, seeking answers towards what context knowledge workers can make use of weak ties in their tasks and for what purposes. A constructive pattern is built to advance some effective measures in knowledge work. Since the focus of the study was on knowledge work-related tasked, there is a possibility that dissimilar evaluations would have arisen if the focus had been on non-knowledge work relevant tasks. This study has gone some way towards enhancing organizations' understanding of the significance of weak ties in knowledge workers' performance. The originality of this paper lies in taking a new look at opportunities of weak ties towards knowledge workers, revisit the significance of weak ties.
Matrix Metalloproteinases as Targets for the Immune System during Experimental Arthritis1

Novel therapies for rheumatoid arthritis aiming at intervention in the inflammatory process by manipulation of autoreactive T and B lymphocytes receive major interest. However, the development of such therapies is largely hampered by the lack of knowledge of self-Ags recognized during the disease process. Recently, we predicted putative T cell self-epitopes based on a computer search profile. In the present study, the predicted self-epitopes were tested for T cell recognition in two experimental arthritis models, and their arthritogenic capacity was analyzed. Fourteen of n = 51 predicted self-epitopes were recognized during experimental arthritis of which six were able to actively induce arthritis. Interestingly, three of these six peptides were derived from matrix metalloproteinases (MMP), and only T cells responsive to MMP-derived epitopes were able to passively transfer arthritis to naive rats. Moreover, we demonstrate the presence of Abs to MMP-3 during the course of adjuvant arthritis. Together these data indicate that MMPs play a pivotal role as target for T and B cells during the development of inflammatory arthritis. This finding sheds new light on the pathophysiological role of MMPs during arthritis and opens novel possibilities for Ag-specific immunotherapy.
Neurotoxic risk caused by stable and variable exposure to methylmercury from seafood.

OBJECTIVES To examine whether the dose-effect relationship for developmental mercury neurotoxicity is affected by variable mercury exposure during pregnancy. METHODS The study was based on a birth cohort of 1022 children born in the Faroe Islands between March 1986 and December 1987. Neurobehavioral performance of 917 children (90%) was assessed at age 7. Intrauterine methylmercury exposure was determined from mercury concentrations in cord blood and 2 sets of maternal hair. Complete exposure information was available for 614 children (67%). RESULTS In children with complete exposure data, 8 of 16 neuropsychological tests showed deficits significantly associated with the cord-blood mercury concentration after confounder adjustment. Variable intrauterine exposure was suggested by disagreement between mercury concentrations in the 2 maternal hair samples. Removal of the 61 children (10%) with the greatest degree of variable exposure had a minimal effect on most exposure-effect relationships. However, the effect of the cord-blood concentration on verbal learning and memory was greater after this exclusion. CONCLUSION The study supports previous findings from this cohort study that maternal mercury exposure during pregnancy is associated with neuropsychological deficits detectable at age 7 years and that this association is evident in women with stable exposures throughout pregnancy. Thus the association is not the result of variable exposures.
Later is better: mobile phone ownership and child academic development, evidence from a longitudinal study

ABSTRACT Digital technologies have become an increasingly prominent feature of children’s lives both within and outside educational environments (McCoy, Quail, and Smyth 2012. Influences on 9-Year-Olds’ Learning: Home, School and Community. Dublin: Department of Children and Youth Affairs). Despite considerable media debate, we have little robust evidence on the impact of technology use on children’s development, both academically and socially. Much of the literature in this area relies on small-scale cross-sectional studies. Using longitudinal data on 8500 9-year-old children in Ireland, we examine the influence of early mobile phone ownership on children’s performance in reading and maths between 9 and 13 years of age. Across both reading and maths domains, children who already report owning a phone by the age of nine fare less well in terms of their academic development as they move into adolescence. The measured effects are sizeable, implying about 4 percentile lower ranking on standardised tests for an average student. Our results are consistent with the idea that there may be significant educational costs arising from early mobile phone use by children. Parents and policymakers should consider whether the benefits of phone availability for children are sufficiently large to justify such costs. We suggest a range of direct and indirect cognitive effects that could help explain these results.
Pareto efficient allocation of an in-motion wireless charging infrastructure for electric vehicles in a multipath network

Abstract Electric vehicles (EV) use an eco-friendly technology that limits the greenhouse gas emissions of the transport sector, but the limited battery capacity and the density of the battery are the major barriers to the widespread adoption of EV. To mitigate this, a good method seems to be the innovative wireless charging technology called ‘On-Line EV (OLEV)’, which is a contactless electric power transfer technology. This EV technology has the potential to charge the vehicle’s battery dynamically while the vehicle is in motion. This system helps to reduce not only the size of the battery but also its cost, and it also contributes to extending the driving range before the EV has to stop. The high cost of this technology requires an optimal location of the infrastructure along the route. For this reason, the objective of this paper is to study the problem of the location of the wireless charging infrastructure in a transport network composed of multiple routes between the origin and the destination. To find a strategic solution to this problem, we first and foremost propose a nonlinear integer programming solution to reach a compromise between the cost of the battery, which is related to its capacity, and the cost of installing the power transmitters, while maintaining the quality of the vehicle’s routing. Second, we adapt the multi-objective particle swarm optimization (MPSO) approach to our problem, as the particles were robust in solving nonlinear optimization problems. Since we have a multi-objective problem with two binary variables, we combine the binary and discrete versions of the particle swarm optimization approach with the multi-objective one. The port of Le Havre is presented as a case study to illustrate the proposed methodology. The results are analyzed and discussed in order to point out the efficiency of our resolution method.
Tremor suppression orthoses for parkinson’s patients: A frequency range perspective

While the majority of tremor-afflicted Parkinso-nian (PD) patients suffer from rest tremors, which is not considered highly disabling, a portion of these PD patients also demonstrate action tremors that interfere with their daily lives. Two main considerations in designing an orthosis that aims at suppressing the tremor, are the frequency bands of the tremor and the joints tremor affects. Nine subjects, which included six healthy people, two PD patients with typical tremor afflictions, and a PD patient with severe tremor of not only in her fingers and wrist, but also in her elbow, participated in this study. The highly afflicted patient displayed the need for tremor suppression in action as well as when in rest. The study focuses on uncommon elbow tremors and demonstrates that, for typically afflicted patients, tremor amplitudes are comparable to healthy subjects, but the frequency distribution of the tremors are different at high levels of elbow torque. For the highly afflicted patient, both tremor amplitude and its frequency distribution are different at all levels of elbow torque. The study further investigates the tremors in two bands of frequency on both hands of the highly troubled patient before, and after medication. The two bands are those of classical Parkinsonian tremor (4-6 Hz) and physiological (or enhanced physiological) tremor (8-12 Hz). Power spectrum and tremor amplitude comparisons reveal that, for part of tremulous PD patients, both tremors coexist and, depending on the level of affliction, the designed orthosis needs to suppress tremors in both bands, even at more proximal joints, such as the elbow.
[Systematic review of studies on the socioeconomic status of men who batter their intimate partners].

BACKGROUND Despite the visibility of intimate partner violence against women in low socioeconomic groups, the association of low socioeconomic status and violent behavior is unclear. We performed a systematic review of the empirical evidence on the causal role of batterers' socioeconomic status in this phenomenon. METHODS We performed a systematic review, using the following databases: Eric (1966-2004), Sociological Abstracts (1963-2005), Science Citation Index (1945-2005), Social Science Citation Index (1956-2005), Medline through Pubmed (1966-2005), Social Service Abstracts (1980-2005), Lilacs (1982-2005) and Psycinfo (1972-2005). We included empirical papers with aims or hypothesis related to the causal relation between low socioeconomic status (employment, education, income) in men and IPV. RESULTS A total of 251 studies were identified, but only 10 met the inclusion criteria. There was one cohort study, one case-control study, one ecological study and one study based on a series of cases. Two studies calculated odds ratio in the analyses. One of these studies reported an odds ratio of 1.4 (95% CI, 1.1-1.9) with unemployment and the other study showed no significant positive associations with this factor or with low income or education. CONCLUSIONS More information and better quality data are required to establish conclusive results on the causal role of the socioeconomic status of men who batter their intimate partners. The empirical evidence on the relationship between violent male behavior against their partners and low socioeconomic status is still insufficient.