Miracle-dz/UniFAR-FTUs huggingface dataset:
Haploidentical Stem Cell Transplantation in Childhood

Abstract: Allogeneic stem cell transplantation has become an important treatment option for many children with malig-nant and non malignant diseases during the past decades. However, this therapy was for a long time restricted to patients having an “HLA identical donor”. In most recent years donor registries all over the world have extended and the numbers of registered volunteers have substantially increased during the last 20 years. In spite of this progress, there is still a sub-stantial number of children lacking a well matched donor. Virtually all little patients have at least one “haploidentical” parent who could potentially serve as a stem cell donor. These donors are immediately available, are highly motivated and could be asked for a further time if the graft would have been rejected. In the post transplant course parents are repeatedly available for additional donor cell transfusions for preemptive immunotherapy. Moreover using haploidentical parents as donors can avoid the inauguration of new registries and banking expenditures in countries whose population is not very much represented in existing large donor registries. For long years, graft rejection, graft versus host disease (GVHD) and delayed recovery of the immune system used to be the limiting factors for haploidentical transplantation. Substantial pro-gress has been made in the clinical application of haploidentical stem cell transplantation in children with leukemia as well as non malignant diseases in the last years. Recurrence of the underlying disease and delayed immune recovery, however, remained major cause for treatment failure yet to overcome to offer this procedure to a wider range of patients. Nevertheless, haploidentical stem cell transplantation has become a valuable alternative procedure for patients lacking an HLA identical donor. The development and recent advance is reviewed in the following.
Ecology and evolution of mutualistic networks

Mutualistische interacties komen overal voor in de natuur en zijn cruciaal voor de overleving en reproductie van veel soorten. Sinds kort wordt pas erkend dat mutualistische interaties belangrijk zijn voor de verbindingen tussen soorten, voor de modulatie van ecosysteemfunctionering en voor het behoud van biodiversiteit. Mutualistische gemeenschappen, zoals plant-bestuiver gemeenschappen, kunnen worden beschreven als netwerken van interacties tussen mutualistiche partners (bijv. planten en dieren). Met behulp van deze aanpak hebben vele studies hun licht kunnen schijnen op de structuur van mutualistische gemeenschappen en hun eco-evolutionaire patronen. De vraag is: welke ecologische en evolutionaire processen liggen ten grondslag aan de opbouw van mutualistische gemeenschappen? We hebben wiskundige modellen en simulaties ontwikkeld en deze gecombineerd met data analyse om deze vragen te kunnen beantwoorden voor een scala aan mutualistische systemen, waarbij we vooral gefocust hebben op mutualistische plant-dier interacties. We hebben gevonden dat spatio-temporele variabiliteit de belangrijkste factor is van de mutualistische netwerk structuur. De combinatie van ruimtelijke structuur en de variabiliteit in de timing van interacties tussen soorten (fenologie) is wat het meest de mutualistische netwerkstructuur bepaald. De stabiliteit en diversiteit van deze gemeenschappen hangt echter af van de balans van deze processen met andere typen ecologische interacties en de life-history van de soort. Bovendien blijkt het dat veel voorkomende evolutionaire patronen in mutualistiche netwerken, zoals evolutionaire convergentie en complementariteit, lijken te ontstaan uit simpele ecologische (bijv. dispersielimitatie en ecologische drift) en evolutionaire (bijv. mutatie, recombinatie en genetische drift) processen. We concluderen dat: 1) neutrale eco-evolutionare processen niet moeten worden genegeerd bij het bestuderen van de evolutie van ecologische netwerken en 2) ruimtelijke processen (dispersielimitatie, immigratie) en fenologie van essentieel belang zijn voor de samenstelling van mutualistische netwerken, en waarschijnlijk voor ecologische netwerken in het algemeen.
A distributed-RCL model for MCM layout

The authors model high-speed VLSI interconnects by using a generic distributed RLC-tree. Through a detailed analysis of the distributed RLC-tree a two-pole approximation system is established to formulate the performance-driven layout in MCM designs. An in-depth study of the formulated performance-driven layout problem reveals the interplay between the interconnector's performance and its geometrical parameters. The study leads to an A-tree topology to optimize the defined performance-driven layout problem. Significant improvement, an average up to 67% reduction on the interconnection delay, is achieved over large sample MCM designs, as compared with the well known Steiner tree topology. <<ETX>>
Modélisation d'Objets 3D en vue de leur reconnaissance et leur manipulation par un robot personnel

Ce papier decrit les fonctions visuelles a integrer sur un robot personnel qui doit manipuler des objets 3D : il est focalise sur l'apprentissage des representations geometriques et photometriques de ces objets. Notre methode est fondee sur l'extraction et la mise en correspondance de points d'interet depuis des images acquises par une seule camera deplacee autour de l'objet en phase d'apprentissage. Tout d'abord, l'objet est segmente dans les images en supposant le fond statique ou uniforme ; puis, a partir de pixels extraits et apparies dans des images acquises depuis plusieurs points de vue, un ensemble de points 3D est reconstruit, d'abord par une simple triangulation, puis par un ajustement de faisceaux ; a chaque point 3D est associe l'ensemble des signatures des points d'interet qui sont ses projections dans les images d'apprentissage ; un maillage est construit a partir de ces points 3D. Ces representations seront ensuite exploitees pour reconnaitre, localiser et manipuler ces objets.
Evaluating User Centered Design of E-Health for Older Adults: Using Subjective Methods

Health care related technology, or E-health, has the potential to lessen the impact of the growing aging population on the health care system and support older adults' preference for aging in place. However, for technologies to be adopted by older users, research is needed to understand older adults' unique health care needs, their preferences for support, and their perceptions of technologies designed for health care. Specifically directed toward older users, this article highlights the need for user-centered design and the implications for technology acceptance, and describes studies that employed systematic subjective methods such as focus groups, interviews, and questionnaires to provide a rich, detailed depiction of older users' interactions with E-health. User-centered design evaluations involving older adults can help designers create products and services that are more likely to be adopted by older adult end users.
Segmentation non supervisée d'images angiographiques de la rétine par le système de Pearson et le reéchantillonnage bootstrap

In this paper, we present a method for fast image segmentation. This method combines the robustness of Bayesian classification, the efficiency of the Expectation Maximization algorithms for identifying mixtures particularly under the Pearson system and the bootstrap resampling. In this context, we propose an experimental criterion of representativity of the sample using the technique of bootstrap in the estimation of generalized mixtures. This method is applied to the problem of segmentation of images in a sequence of retinal angiography which is corrupted by a non-Gaussian noise and where the computation time is a criterion for choosing the method of segmentation. The result of segmentation obtained with the bootstrap resampling is quite the same compared to the one obtained in the classical case but with a significant reduction in time computing.
Haemoptoe, Pneumothorax und chronische respiratorische Insuffizienz bei Mukoviszidose

Pulmonale Komplikationen sowie chronisch progrediente oder akute respiratorische Insuffizienz sind bei Mukoviszidose mit fortgeschrittener Lungenbeteiligung haufig. Als Ursachen akuter pulmonaler Verschlechterung sind insbesondere Infektexacerbation, allergische bronchopulmonale Aspergillose (ABPA), Hamoptoe und Pneumothorax zu nennen. Die Therapie zielt primar auf die Aufrechterhaltung der Vitalparameter und Beseitigung einer begleitenden Hypoxie und gegebenenfalls Hyperkapnie. Uber die weitere Therapie ist aufgrund der interindividuellen hohen Variabilitat des Krankheitsbildes Mukoviszidose in jedem Einzelfall zu entscheiden. Dieser Artikel soll dem Haus- oder Notarzt, der mit den pulmonalen Notfallen bei Mukoviszidose konfrontiert wird, Informationen geben uber die therapeutischen Interventionsmoglichkeiten sowie auf typische bei Mukoviszidose auftretende Probleme hinweisen. Pulmonary complications, as well as chronic progressive or acute respiratory failure are common in mucoviscidosis with advanced pulmonary involvement. Major causes of acute pulmonary exacerbations are due in particular to infections, allergic bronchopulmonary aspergillosis (ABPA), haemoptysis and pneumothorax. Treatment concentrates primarily on the preservation of vital parameters and the elimination of concomitant hypoxia and, where applicable, hypercapnea. In view of the great interindividual variability of mucoviscidosis, the further therapeutic measures must be decided on an individual basis. The present article provides the general practitioner or emergency physician confronted with a pulmonary emergency in a mucoviscidosis patient with information on therapeutic options and typical problems associated with mucoviscidosis.
Reducing Packet loss in Active Queue Management

Random Early Detection (RED) is a network congestion control algorithm which detects incipient congestion according to current length of average queue. It detects congestion only after a packet has been dropped. In the recent, high speed networks, it is important to have some mechanisms that keep throughput high and average queue sizes low without packet loss and it would be undesirable to have large queue because it would significantly increase the average delay in the network.
Mutation Operators for Ada

Mutation analysis is a method for testing software. It provides a method for assessing the adequacy of test data. This report describes the mutation operators de ned for the Ada programming language. The mutation operators are categorized using syntactic criteria, in a form suitable for an implementor of a mutation-based system, or a tester wishing to understand how mutation analysis can be used to test Ada programs. Each mutation operator is carefully de ned, and when appropriate, implementation notes and suggestions are provided. We include operators for all syntactic elements of Ada, including exception handling, generics, and tasking. A summary table listing all operators for Ada, and compared with C and Fortran operators is also provided. The design described here is the result of deliberations among the authors in which all aspects of the Ada language and software development in Ada were considered. These operators can also be viewed as the culmination of previous mutation operator de nitions for other languages. This report is intended to serve as a manual for the Ada mutation operators. 1 MUTATION APPLIED TO ADA Although mutation has been applied to several languages, the Ada programming language presents several new features, both syntactic and semantic. Most of the mutation operators for other languages are still meaningful for Ada, with appropriate changes in the names. In this section, we discuss these new features and make recommendations for handling them. 1.1 Strong Typing in Ada Ada's strong typing requires that mutation operators be applied more strictly than in previous languages. Ada's static semantic restrictions, which enhance program reliability and readability, make brute-force ap-
School libraries 3.0 : principles and practices for the digital age

Preface Chapter 1: The School Library and the School Librarian Chapter 2: Standards and Guidelines Chapter 3: Policies and Procedures Chapter 4: Money Chapter 5: Facilities Chapter 6: Relationships and Personnel Chapter 7: Services Chapter 8: Programming and Collaboration Chapter 9: Ethics, Intellectual Freedom, and Copyright Chapter 10: Advocacy Chapter 11: The "Extra" Things Chapter 12: Evaluation and the Future Appendix 1: Annotated Bibliography of Selected School Library Policies and Procedures Manuals Appendix 2: Annotated Bibliography of Selected School Library Professional Organization Web Sites Appendix 3: Annotated Bibliography of Selected National and State School Library Standards and Guidelines Appendix 4: Annotated Bibliography of Selected School Library Instruction and Collaboration Tools Appendix 5: Annotated Directory of Selected Grant Resources for School Libraries About the Author Index
Neural network analysis of structural damage due to corrosion

We attempt to develop a practical decision support system for the damage assessment of structural corrosion. This system aims to aid inexperienced inspectors to judge whether a certain bridge should be repaired or not. For this purpose, it is attempted to apply the neural network technique for the damage assessment. The learning ability of the neural network is useful to save the working time and load necessary in the inspection and analysis.
ATTITUDES OF TEACHERS TOWARDS IMPLEMENTATION OF INCLUSIVE EDUCATION IN NYAMIRA COUNTY, KENYA

The purpose of the study was to find out the attitudes of teachers towards implementation of inclusive education in Nyamira County, Kenya. The study adopted a descriptive survey design. The study targeted 4000 and 5 education officers in Nyamira County. They are involved in the implementation and delivery of the curriculum. The study used simple random sampling. The study observed that the attitude of teachers towards inclusive education was negative. The negativity of teachers was due to variables such as the teacher’s lack of knowledge and skill of disabilities; the need for special curriculum for learners in inclusive education; low achievement of SNE children and increased indiscipline cases. The study recommended that: Teachers should recommend severe cases of disability to special schools; teachers to recommend to the ministry of education areas of the curriculum that require change to meet needs of all learners in inclusive settings; all teachers be trained.
Modèles de saillance visuelle par fusion d'informations sur la luminance, le mouvement et les visages pour la prédiction de mouvements oculaires lors de l'exploration de vidéos.

Lorsque nous explorons une scene visuelle nous focalisons notre attention et notre regard sur certaines regions de la scene dites saillantes an d'etudier ces regions plus en detail. L'objectif de cette these etait de mieux comprendre les processus attentionnels qui guident le regard lorsque nous regardons une video et de modeliser ces processus. Deux approches complementaires ont ete adoptees : une approche comportementale, a l'aide d'experiences d'oculometrie, pour mieux comprendre comment les personnes regardent une video et une approche de modelisation afin de proposer un modele, inspire du systeme visuel humain, permettant de mettre en evidence les regions saillantes dans des videos. Deux modeles ont ete proposes. Le premier modele de saillance a deux voies, extrait des cartes statiques et dynamiques a partir des informations sur la luminance et le mouvement. Les traitements de ces deux voies, bien que relativement independants, sont realises par des modules communs (filtre "retinien" et filtres "corticaux") a l'instar de ce qui est fait dans le systeme visuel. Un deuxieme modele de saillance, a trois voies, integre au modele precedent une voie dediee a la detection des visages, les visages etant connus pour attirer les regards. Des experiences d'oculometrie ont permis d'etudier et d'evaluer ces modeles de saillance en detail.
APROXIMACIÓN AL LÉXICO DEL TURISMO ACTIVO: CODIFICACIÓN LEXICOGRÁFICA, FORMACIÓN Y VARIACIÓN DENOMINATIVA 1 APPROACH TO THE LEXICON OF ACTIV TOURISM: LEXICAL CODIFICATION, WORD FORMATION AND WORD VARIATION

PALABRAS CLAVE: turismo activo, lexico, Internet, codificacion lexicografica, formacion, variacion. ABSTRACT: This article describes the lexicon that makes up the so-called active tourism of the European Spanish. It is analyzed from three points of view: the encoding in dictionaries, contrasting the dictionary of the Real Academia Espanola with other dictionaries; the formation of the units, which covers the phenomenon of the loan and the different mechanisms of creation of words; and, thirdly, the lexical variation that characterizes this vocabulary. The corpus of voices and signs of use has been extracted from Internet, in particular certain legislative fonts available on the network and different promotional web pages. Similarly, electronic dictionaries have been taken as reference, in connection with the above mentioned project which belongs this study.
Ultrasonic image analysis for liver diagnosis

The authors propose a new ultrasonic image analysis system that can be utilized as an effective tool in classifying liver states as normal, hepatitis, or liver cirrhosis. In this system, the authors first define suitable settings for the ultrasonic device, then remove the inhomogeneous structures from the area of interest in the image, and then, by using the forward sequential search method, look for the useful texture parameters from the co-occurrence matrix, the statistical feature matrix, the texture spectrum, and the fractal dimension descriptors. Finally, the selected parameters are fed into a probabilistic neural network for the classification of liver disease. Experimental results are presented that show the classification rate with and without the inclusion of the inhomogeneous structures.
A New Theoretical Approach to Location Based Power Aware Routing

In MANETs, when information is sent from the source to the destination, these information packets travel through all the nodes which come across the path from the source to the destination. If the battery backup of any node across this path is less than the minimum time required to transmit the information packets from the source to the destination, then this information cannot be sent. In this proposed work, alternate methods are proposed to overcome this problem. One such proposed solution is to utilize Root up time Factor (RUF) for calculating the battery backup of all the nodes and then to use only those nodes which have maximum battery backup.
Characterisation of Methicillin Resistant Staphylococcus aureus Isolates from Hospitalised Patients

The occurrence of Panton Valentin leukocidin in 99 invasive MRSA strains isolated from hospitalized patients was shown to be around 9,1 %. Five of nine PVL positive strains had SCCmec type IV casette. The predominating SCCmec type in PVL negative and SCCmec typable MRSA was II. Such strains were simultaneously resistant to erythromycin, clindamycin and ciprofloxacin. The linezolid resistance in invasive MRSA strains from Slovak hospital was not recorded. The MLVA characterization of 8 PVL positive isolates from various locations has demonstrated three different patterns. Except one hospital, isolates from over the country expressed the same MVLA pattern.
Pulse Wave Velocity: Relevance of Age in Normotensive, Essential Hypertensive and Borderline Hypertensive Patients

Background: Among the various parameters used to describe arterial function, pulse wave velocity (PWV) is the only oneallowing direct measurement of arterial stiffness. Loss of arterial elastic capacity with increasing age, a process known asvascular aging, is enhanced in hypertensive patients.Objectives: The aim of this study was to normalize PWV in normotensive (NT), essential hypertensive (HT) and borderlinehypertensive (BL) patients and differentiate the effects of aging on PWV from those associated to hypertension.Methods: A total of 221 consecutive male and female patients were included in the study. They were classified into threegroups according to their blood pressure (BP) values: NT (n=120, 46±13 years): BP 140/90 mmHg; and BL (n=41, 47±12 years): BP=135-139/85-89 mmHg. They were then stratified into fourgroups according to age: GI 60 years. Mechanographic transducersand computerized calculation were used to measure PWV. Data analysis was performed using ANOVA, Newman-Keuls, andmultivariate linear regression tests.Results: Pulse wave velocity increased with age in all age groups (p<0.05). Mean PWV (m/s) in G1 was: NT (n=42): 8.6±1.1,HT (n=16): 9.5±1.3, BL (n=10): 9.0±0.5; in GII: NT (n=24): 9.5±1.2, HT (n=16): 10.7±1.2, BL (n=14): 9.8±0.8; in GIII:NT (n=30): 10.3±1.5, HT (n=12): 12.1±1.5, BL (n=11): 11.0±1.3; and in GIV: NT (n=24): 11.4±1.8, HT (n=16): 14.1±2.4,BL (n=6): 13.3±1.1. Regression equations were: for NT, PWV=0.08 × age+0.04 × systolic blood pressure (SBP)+1.07 (r=0.71); for HT, PWV=0.12× age+0.06 × SBP-2.51 (r=0.81); and for BL, PWV=0.10 × age+0.02 × SBP+2.90 (r=0.73) (p<0.05). Conclusions: Pulse wave velocity increased with age, and was higher in HT patients for each age group. Borderline hypertensivepatients presented intermediate values between the other two groups. These results suggest additional vascular impairmentinduced by hypertension over that of aging. This surplus effect could be estimated from the regression equation obtainedfor each group.
New ESD protection schemes for BiCMOS processes with application to cellular radio designs

A new electrostatic discharge (ESD) protection network that allows arbitrary combinations of BiCMOS circuit components to be protected is described along with a methodology for designing ESD protection circuitry. The methodology is predictive, and can be simulated on SPICE. Results from 900 MHz cellular radio ICs fabricated in a 1 mu m 13 GHz F/sub T/ BiCMOS process verified the new techniques. A new crowbar power-to-ground clamp capable of nondestructively sinking 5 A of ESD current in 100 ps is described. The clamp voltage was bandgap referenced and therefore stabilized against process variations. All ESD network components were produced with the standard fabrication flow. <<ETX>>
Contextual influences on the comprehension of complex concepts

Abstract Four experiments demonstrated that the comprehension of novel compound nouns involves the recognition of a general relationship between two categories. Experiment 1 found that reading time is not impaired when a story only implicitly gives the relation underlying a compound noun. Experiment 2 demonstrated that comprehension of both explicit and implicit compounds allows swift and accurate verification of their meanings in a delayed recognition teSt Experiment 3 showed that interpreting both explicit and implicit compounds facilitates later comprehension relying on that interpretation. Experiment 4 found that comprehension of a novel compound facilitates processing of a second compound that shares a similar categorical relation, even when there is no lexical overlap.