Miracle-dz/UniFAR-FTUs huggingface dataset:
EPISODE: Efficient Privacy-PreservIng Similar Sequence Queries on Outsourced Genomic DatabasEs

Nowadays, genomic sequencing has become much more affordable for many people and, thus, many people own their genomic data in a digital format. Having paid for genomic sequencing, they want to make use of their data for different tasks that are possible only using genomics, and they share their data with third parties to achieve these tasks, e.g., to find their relatives in a genomic database. As a consequence, more genomic data get collected worldwide. The upside of the data collection is that unique analyses on these data become possible. However, this raises privacy concerns because the genomic data uniquely identify their owner, contain sensitive data about his/her risk for getting particular diseases, and even sensitive information about his/her family members. In this paper, we introduce EPISODE - a highly efficient privacy-preserving protocol for Similar Sequence Queries (SSQs), which can be used for finding genetically similar individuals in an outsourced genomic database, i.e., securely aggregated from data of multiple institutions. Our SSQ protocol is based on the edit distance approximation by Asharov et al. (PETS'18), which we further optimize and extend to the outsourcing scenario. We improve their protocol by using more efficient building blocks and achieve a 5-6x run-time improvement compared to their work in the same two-party scenario. Recently, Cheng et al. (ASIACCS'18) introduced protocols for outsourced SSQs that rely on homomorphic encryption. Our new protocol outperforms theirs by more than factor 24000x in terms of run-time in the same setting and guarantees the same level of security. In addition, we show that our algorithm scales for practical database sizes by querying a database that contains up to a million short sequences within a few minutes, and a database with hundreds of whole-genome sequences containing 75 million alleles each within a few hours.
DETAILED ANALYSIS OF ACCORDING TO THE REC

The paper is concerned with specific problems o meter implementation in class A and class S power quality analyzers according to the most recent IEC standards, for class F1 and F3 respectively as defined in IEC 61000-4-15 ed.2.0. Test results of designed prototypes are included and compared with our previous implementations. We have focused to introduce the fully compliant correct flicker meters and understand the minimal requirements fo implementation. INTRODUCTION Voltage fluctuations are one of the many areas defi ning the complete power quality monitoring. One of the parameters indicating the volt age fluctuation is flicker. Flicker specification comes from observations of a subjective unpleasant sensation of flashing lights by human eye and brain [1]. Evaluation of the flicker as a power quality index focuses on voltage fluctuations of low frequency from 0.5 to about 35 Hz. Flicker became observed and monitored because alrea dy at voltage fluctuation only a few tenths of a perce nt causes unpleasant changes in the perception of the light radiation of different light sources and thus adver sely affect the human body [2]. Because the human eye is extremely sensitive to flicker voltage, change must be kept within very strict limits. Flickering in power systems is caused by transients (large changes in power consumption) or usage of nonlinear arc furnaces, machines etc. (harmonic distortion generally). The paper follows an implementation of class F1 fli cker meter developed on our own modular ARTIQ platform. This device represents a modular PQ common low cost 32-bit ARM microcontrolle quality 16/24bit AD convertor. We compare this implementation with our previous IEC 61000 [3] flicker meter with simpler analog hardware analyzer and with more recent class F3 flicker meters (PQ-S1and PQ-S2). Implementation of flickermeter is performed according to the standard IEC 61000-415 ed. 2.0 [ highlights some pitfalls of calculating flicker in a general power quality analyzer . Some partial development achievements were already published in [ 1/5 CLASS F1 / F3 FLICKER METER IMPLEMENTATI ENT IEC STANDARDS Leoš Kukačka Jan KRAUS TU in Liberec – CZE TU in Liberec Leos.Kukacka@tul.cz Jan.Kraus@tul.cz
P o S ( A P C S 2 0 1 6 ) 0 5 6 Accretion-Outflow Activity in Herbig Ae / Be Stars

Young intermediate mass stars, so-called Herbig Ae/Be stars, demonstrate both accretion and outflow features in their emission spectra. Using non-LTE modeling of the hydrogen lines in the visible and near-infrared spectral regions we investigated a close vicinity of these stars and revealed the most important regions contributing to the line emission. The regions of the disk wind play the most important role in the radiation of the hydrogen lines. The regions with accreting matter contribute less to this radiation but can influence the shape of the line profiles. We conclude that a role of accreting processes may be different for the different stars. A radiation from the hot layers of accretion disks is small for the lines in the visible and negligible for the lines in the infrared spectral regions compared to other components surrounding Herbig Ae/Be stars.
Virtual-grasping influences visual exploration in hemispatial neglect: a preliminary eye-tracking study

The present study aims at investigating dissociations between vision-for-action and vision-for-perception in hemispatial neglect patients through eye-tracking. Three patients and ten controls completed two gap-bisection tasks. While patients showed a rightward bias during the perceptual task, in the virtual-grasping task we have not found evidences for a similar deviation.
TO JHEP IFIC / 1694 Heavy Higgs Boson Production at Colliders in the Singlet-Triplet Scotogenic Dark Matter Model

We consider the possibility that the dark matter particle is a scalar WIMP messenger associated to neutrino mass generation, made stable by the same symmetry responsible for the radiative origin of neutrino mass. We focus on some of the implications of this proposal as realized within the singlet-triplet scotogenic dark matter model. We identify parameter sets consistent both with neutrino mass and the observed dark matter abundance. Finally we characterize the expected phenomenological profile of heavy Higgs boson physics at the LHC as well as at future linear Colliders.
Dissociation of [3H]L-glutamate uptake from L-glutamate-induced [3H]D-aspartate release by 3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid and 3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid, two conformationally constrained aspartate and gluta

We characterized the interaction of two conformationally constrained aspartate and glutamate analogs, 3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid (HIP-A) and 3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid (HIP-B), with excitatory amino acid transporters (EAATs) in rat brain cortex synaptosomes. HIP-A and HIP-B were potent and noncompetitive inhibitors of [(3)H]L-glutamate uptake, with IC(50) values (17-18 microM) very similar to that of the potent EAAT inhibitor dl-threo-beta-benzyloxyaspartic acid (TBOA). The two compounds had little effect in inducing [(3)H]D-aspartate release from superfused synaptosomes but they potently inhibited l-glutamate-induced [(3)H]D-aspartate release, thus behaving as EAAT blockers, not substrates, in a manner similar to those of TBOA and dihydrokainate (DHK). HIP-A and HIP-B, but not TBOA and DHK, unexpectedly inhibited L-glutamate-induced [(3)H]D-aspartate release with IC(50) values (1.2-1.6 microM) 10 times lower than those required to inhibit [(3)H]L-glutamate uptake. There is therefore a concentration window (1-3 microM) in which the two compounds significantly inhibited l-glutamate-induced release with very little effect on L-glutamate uptake. This selective inhibitory effect required quite long preincubation (>5 min) of synaptosomes with the drugs. At these low concentrations, however, HIP-A and HIP-B had no effect on the EAAT-mediated [(3)H]d-aspartate release induced by altering the ion gradients, indicating that they specifically affect some L-glutamate-triggered process(es)--different from L-glutamate translocation itself--responsible for the induction of reverse transport. These data are inconsistent with the classic model of facilitated exchange-diffusion and provide the first evidence that EAAT-mediated substrate uptake and substrate-induced EAAT-mediated reverse transport are independent. Compounds such as HIP-A and HIP-B could be useful to further clarify the mechanisms underlying these operating modes of transporters.
Precipitation Distribution Associated with Landfalling Tropical Cyclones over the Eastern United States

Abstract Tropical cyclones (TCs) making landfall over the United States are examined by separating those associated with precipitation predominantly left of their tracks from those with the same to the right of their tracks. Composites of atmospheric variables for these two TC categories are performed and analyzed using potential vorticity (PV) and quasigeostrophic (QG) frameworks. Dynamical signatures are retrieved from these composites to help understand the evolution of precipitation in these storms. Results indicate that a left of track precipitation distribution (e.g., Floyd 1999) is characteristic of TCs undergoing extratropical transition (ET). In these cases, a positively tilted midlatitude trough approaches the TC from the northwest, shifting precipitation to the north-northwest of the TC. Potential vorticity redistribution through diabatic heating leads to enhanced ridging over and downstream of the TC, resulting in an increase in the cyclonic advection of vorticity by the thermal wind over the .
Child language and parenting antecedents and externalizing outcomes of emotion regulation pathways across early childhood: A person-centered approach

Abstract Decreases in children's anger reactivity because of the onset of their autonomous use of strategies characterizes the prevailing model of the development of emotion regulation in early childhood (Kopp, 1989). There is, however, limited evidence of the varied pathways that mark this development and their proposed antecedents and consequences. This study used a person-centered approach to identify such pathways, antecedents, and outcomes. A sample of 120 children from economically strained rural and semirural households were observed while waiting to open a gift at ages 24, 36, and 48 months. Multitrajectory modeling of children's anger expressions and strategy use yielded three subgroups. As they aged, typically developing children's strategy use (calm bids and focused distraction) increased while anger expressions decreased. Later developing children, though initially elevated in anger expression and low in strategy use, demonstrated marked growth across indicators and did not differ from typically developing children at 48 months. At-risk children, despite developing calm bidding skills, did not display longitudinal self-distraction increases or anger expression declines. Some predicted antecedents (12–24 month child language skills and language-capitalizing parenting practices) and outcomes (age 5 years externalizing behavior) differentiated pathways. Findings illustrate how indicator-specific departures from typical pathways signal risk for behavior problems and point to pathway-specific intervention opportunities.
A Model for Magnetization Transfer in Tissues

Magnetization transfer in several tissues is measured and successfully modeled using a two‐pool model of exchange. The line shape for the semi‐solid pool is characterized by a superLorentzian and the liquid pool by a Lorentzian. The tissues investigated were white and gray matter, optic nerve, muscle, and liver. All tissues the authors studied are characterized by the same model but differ in the parameter values of the model. Blood and cerebral spinal fluid (CSF) were also investigated. The two‐pool model with a Lorentzian line shape for both the semi‐solid and liquid pools modeled the magnetization transfer in blood. In CSF, as expected, there is no measurable exchange of magnetization. The T2B associated with the semi‐solid pool was short (˜10 μ) for all tissues indicating a fairly rigid semi‐solid pool. In addition characterization of the line shape as superLorentzian indicates molecules such as integral membrane proteins or lipids in membranes are likely molecules participating in the exchange. Conversely, in blood large globular proteins are indicated due to the Lorentzian nature of the semi‐solid pool and a T2B ≈ 300 μs.
Chapter 1 SEASONALITY OF INNATE IMMUNITY ; EVOLUTIONARY ASPECTS AND LATEST UPDATES

Innate immunity is the first line defense of all animals against novel pathogens and parasites. Exposure to many parasites and pathogens varies seasonally following the lifecycle of the parasite or due to intra-annual variation in the infectivity of pathogens. At the same time the reproductive cycle of the host co-varies with changes in the environment resulting in a seasonally varying fitness landscape. Organisms face these seasonal challenges by regulating their internal physiology, i.e. by secreting hormones. Melatonin and steroid hormones contribute to the seasonal redistribution of immunological activity including winter-time up-regulation of some immune defenses, and reproduction-related immunosuppression. Whereas ectotherm’s immune functions are directly exposed to seasonal variations in environmental temperature, seasonality drives immunity also in endotherms mainly through photoperiodicity. Further, innate immune functions have been demonstrated to involve condition and stress-dependent components, which link the seasonal fluctuations, for example, in the availability of food to the seasonal variation in immune functions. Therefore, seasonal regulation of the immune defense has likely adapted along evolutionary lines to meet the requirements arising both within and outside individuals. Recently, the importance of seasonal variation in immunity has been increasingly emphasized due to its underlying importance in ecology, behavior and mate choice. In this chapter, we review recent studies of seasonal variation in innate immunity in an evolutionary context among a wide range of animals but concentrating mainly on ectothermic vertebrates and invertebrates. 1 E-mail: raine.kortet@oulu.fi 2 E-mail: anssi.vainikka@fiskeriverket.se No part of this digital document may be reproduced, stored in a retrieval system or transmitted in any form or by any means. The publisher has taken reasonable care in the preparation of this digital document, but makes no expressed or implied warranty of any kind and assumes no responsibility for any errors or omissions. No liability is assumed for incidental or consequential damages in connection with or arising out of information contained herein. This digital document is sold with the clear understanding that the publisher is not engaged in rendering legal, medical or any other professional services. Raine Kortet and Anssi Vainikka 14
CHEMOMODULATORY EFFECT OF DIOSGENIN ON XENOBIOTIC DETOXIFYING ENZYMES AND FREE RADICAL SCAVENGING ACTIVITIES

Considerable attention has been paid to identify potential modulators of free radical scavengers. Diosgenin, a steroidal sapogenin is tested in Swiss albino mice with 50 mg/kg body weight and 30 mg/kg body weight, per oral route based on acute oral toxicity test. Effect on mice serum glutamate-pyruvate transaminase (SGPT) and serum glutamate-oxaloacetate transaminase (SGOT) levels were considered. Hepatic system of mice recorded significant elevation in the specific activity of Cytochrome P450 and Cytochrome b5. Increase in specific activity of GST was evident with augmentation of GSH level. Diosgewnin positively regulated the specific activity of glutathione reductase (GR) and glutathione peroxidase (GPx). Catalase levels recorded an increase with a sharp decline in lipid peroxidation. Our study has established that diosgenin is bifunctional inducers of xenobiotic detoxifying enzymes and possess significant free radical scavenging potential, providing a lead for development novel antioxidant.
EXPLAINING LIQUIDITY DYNAMICS IN THE ORDER DRIVEN

The paper investigates the dynamics of several intraday liquidity measures for the Reuters Dealing 3000 Spot Matching System that constitutes a major order driven interbank spot market for the EUR/ PLN. We derive the time-of-day and the day-of-week effects for different liquidity variables representing the shape of the limit order book. In order to capture the strong persistence exhibited by liquidity, the long memory Autoregressive Conditional Duration (ACD) models are applied. Special attention is paid to the impact of information arrival on liquidity uctuations. We document the signi cant positive impact of probability of informed trading (PIN) on the price impact of trading and the bid-ask spread and the negative impact of the PIN on the liquidity supply on the ask side of the market (orders to sell euro), after controlling for the effects of other covariates such as the trading volume, volatility or previously observed returns.
Searches for Galactic Neutron Sources with the Pierre Auger Observatory

A flux of neutrons from an astrophysical source within our Galaxy would be detected by the Pierre Auger surface detector as an excess of air showers arriving from the direction of the source. In order to reduce the statistical penalty incurred by multiple trials, classes of candidate sources are analyzed collectively as target sets or “stacks”. Individual candidate sources are weighted in proportion to their electromagnetic flux and to their exposure to the Auger Observatory. The results are summarized as a combined p-value for each of the stacks, along with information about the candidate source with the minimum individual p-value in each stack. No significant excess flux is found from the targets considered.
Mitochondria and cell bioenergetics: increasingly recognized components and a possible etiologic cause of Alzheimer's disease.

SIGNIFICANCE Mitochondria and brain bioenergetics are increasingly thought to play an important role in Alzheimer's disease (AD). RECENT ADVANCES Data that support this view are discussed from the perspective of the amyloid cascade hypothesis, which assumes beta-amyloid perturbs mitochondrial function, and from an opposite perspective that assumes mitochondrial dysfunction promotes brain amyloidosis. A detailed review of cytoplasmic hybrid (cybrid) studies, which argue mitochondrial DNA (mtDNA) contributes to sporadic AD, is provided. Recent AD endophenotype data that further suggest an mtDNA contribution are also summarized. CRITICAL ISSUES AND FUTURE DIRECTIONS Biochemical, molecular, cybrid, biomarker, and clinical data pertinent to the mitochondria-bioenergetics-AD nexus are synthesized and the mitochondrial cascade hypothesis, which represents a mitochondria-centric attempt to conceptualize sporadic AD, is discussed.
Weight-based Wear-leveling considering Performance in Phase Change Memory

Phase Change Memory (PCM) is one of the most promising memories which can replace traditional memories. However, PCM requires wear-leveling scheme due to a limited write counts. Although many works study for wear-leveling, there is a lack of consideration for system performance degradation caused by wear-leveling. Therefore, we propose weight-based wear-leveling that minimizes the impact on system performance by considering write count, write locality, and wear-leveling overhead. When PCM is used as storage, the proposed method reduces the write standard deviation by an average of 47.4% and a maximum of 74.8% compared to the baseline. Also, when PCM is used as main memory, the standard deviation decreased by an average of 65% and a maximum of 86.9%, and the read latency was improved by 21.8%. Keywords-component; Phase Change Memory, wear-leveling, write count, write locality, system performance
Extraction and Purification of Phycoerythrin-A Natural Colouring Agent from Spirulina platensis

Phycoerythrin (PE) is a natural colouring agent found in blue green algae, such as Spirulina platensis and is used as natural colour agent in food and beverage industries. In the present study, PE was extracted from Spirulina platensis by freezing and thawing method and purified by ammonium sulphate precipitation followed by anion exchange chromatography using DEAE cellulose and acetate buffer. Recovery of PE after ammonium sulphate precipitation was 80.25% with purity of 2.60 and after chromatography; it was 56.94% with purity of 4.74. Purified PE showed absorption maxima at 565 nm that is the characteristic of C-PI group of phycoerythrins. Electrophoretic analysis revealed that the purified PE has two subunits viz α and β with molecular weight of 17 kDa and 19 kDa respectively.
miR-193a-3p Functions as a Tumor Suppressor in Lung Cancer by Down-regulating ERBB4*

Background: ERBB4 plays an important role in the etiology and progression of lung cancer. Results: miR-193a-3p suppressed proliferation and invasion and promoted apoptosis in lung cancer cells and xenograft mice by negatively regulating ERBB4. Conclusion: miR-193a-3p exerted an anti-tumor effect by negatively regulating ERBB4 in lung cancer. Significance: This study may open new avenues for future lung cancer therapies. ERBB4, one of four ErbB receptor tyrosine kinase family members, plays an important role in the etiology and progression of lung cancer. In this study, we found that the ERBB4 protein levels were consistently up-regulated in lung cancer tissues, whereas the mRNA levels varied randomly, suggesting that a post-transcriptional mechanism was involved in regulating ERBB4 expression. Because microRNAs are powerful post-transcriptional regulators of gene expression, we used bioinformatic analyses to search for microRNAs that can potentially target ERBB4. We identified specific targeting sites for miR-193a-3p in the 3′-UTR of ERBB4. We further identified an inverse correlation between miR-193a-3p levels and ERBB4 protein levels, but not mRNA levels, in lung cancer tissue samples. By overexpressing or knocking down miR-193a-3p in lung cancer cells, we experimentally confirmed that miR-193a-3p directly recognizes the 3′-UTR of the ERBB4 transcript and regulates ERBB4 expression. Furthermore, the biological consequences of the targeting of ERBB4 by miR-193a-3p were examined in vitro via cell proliferation, invasion, and apoptosis assays and in vivo using a mouse xenograft tumor model. We demonstrated that the repression of ERBB4 by miR-193a-3p suppressed proliferation and invasion and promoted apoptosis in lung cancer cells and that miR-193a-3p exerted an anti-tumor effect by negatively regulating ERBB4 in xenograft mice. Taken together, our findings provide the first clues regarding the role of miR-193a-3p as a tumor suppressor in lung cancer through the inhibition of ERBB4 translation.