Miracle-dz/UniFAR-FTUs huggingface dataset:
Virtual Reality and Sex Therapy: Future Directions for Clinical Research

Abstract Rapidly growing new technologies are revolutionizing the field of mental health, in terms of both understanding and treating mental disorders. Among these, virtual reality (VR) is a powerful tool providing clients with new learning experiences benefiting their psychological well-being. This article offers an overview of the current literature on VR in psychotherapy, highlighting its relevance to sexual dysfunction (SD) treatment. A literature review of PubMed and Google Scholar databases was used to provide a description of the theoretical frameworks and clinical indications associated with VR use in psychotherapy and SD treatment. The effectiveness of VR exposure-based therapy has been empirically validated for several mental disorders, notably anxiety disorders. The emerging combined use of VR and mindfulness tends to focus on chronic pain treatment. Experimental research examining the use of immersive technologies in the treatment of SDs is lacking. Given the shortcomings of conventional SD treatments, exploring and developing specialized VR interventions may prove beneficial. VR offers promising avenues in sex therapy, particularly for the treatment of genital pain disorders or SDs in which anxiety plays a significant etiological role.
Differential immunomodulatory effects of human bone marrow-derived mesenchymal stromal cells on natural killer cells.

Mesenchymal stromal cells (MSCs) modulate immune responses via cell contact-dependent or paracrine mechanisms and are themselves known to have low immunogenicity. Given the increasing use of both natural killer (NK) cells and MSCs in cell-based therapies, we investigated the interaction between the two cell types using the NK cell lines, KHYG-1 and NK-92 and human bone marrow-derived MSCs. NK lines were co-cultured with MSCs, either directly or in a transwell system, and the effects on proliferation, interferon-gamma (IFN-) production and cytolytic activity of NK cells were analyzed. Cytotoxicity was measured in a 4 hour chromium release assay. MSCs did not affect the proliferation of NK cell lines but reduced IFN- production by KHYG-1, but not NK-92, when co-cultured directly at 10:1 NK:MSC ratio. MSCs suppressed K562 lysis by both KHYG-1 and NK-92 cells in contact-free transwell co-cultures but only reduced cytotoxicity of KHYG-1 and not NK-92 cells when cells were in direct contact in co-culture. Immunosuppressive effects of MSCs were mediated by indoleamine-2,3-dioxygenase (IDO) and prostaglandin E2 (PGE2) secreted by MSCs and were abrogated in the presence of IDO and PGE2 inhibitors. In the presence of MSCs, granule polarization was suppressed and induced respectively, in KHYG-1 and NK-92. Consistent with this, MSCs were susceptible to lysis by NK-92 but not KHYG-1. These studies indicate the differential crosstalk between MSCs and two highly cytotoxic NK lines and may be important when designing future cell therapy protocols with these two cell types.
Coexpression of IL-5 and Eotaxin-2 in Mice Creates an Eosinophil-Dependent Model of Respiratory Inflammation with Characteristics of Severe Asthma1

Mouse models of allergen provocation and/or transgenic gene expression have provided significant insights regarding the cellular, molecular, and immune responses linked to the pathologies occurring as a result of allergic respiratory inflammation. Nonetheless, the inability to replicate the eosinophil activities occurring in patients with asthma has limited their usefulness to understand the larger role(s) of eosinophils in disease pathologies. These limitations have led us to develop an allergen-naive double transgenic mouse model that expresses IL-5 systemically from mature T cells and eotaxin-2 locally from lung epithelial cells. We show that these mice develop several pulmonary pathologies representative of severe asthma, including structural remodeling events such as epithelial desquamation and mucus hypersecretion leading to airway obstruction, subepithelial fibrosis, airway smooth muscle hyperplasia, and pathophysiological changes exemplified by exacerbated methacholine-induced airway hyperresponsiveness. More importantly, and similar to human patients, the pulmonary pathologies observed are accompanied by extensive eosinophil degranulation. Genetic ablation of all eosinophils from this double transgenic model abolished the induced pulmonary pathologies, demonstrating that these pathologies are a consequence of one or more eosinophil effector functions.
A multi-level strategy for anticipating future glacier lake formation and associated hazard potentials

Abstract. In the course of glacier retreat, new glacier lakes can develop. As such lakes can be a source of natural hazards, strategies for predicting future glacier lake formation are important for an early planning of safety measures. In this article, a multi-level strategy for the identification of overdeepened parts of the glacier beds and, hence, sites with potential future lake formation, is presented. At the first two of the four levels of this strategy, glacier bed overdeepenings are estimated qualitatively and over large regions based on a digital elevation model (DEM) and digital glacier outlines. On level 3, more detailed and laborious models are applied for modeling the glacier bed topography over smaller regions; and on level 4, special situations must be investigated in-situ with detailed measurements such as geophysical soundings. The approaches of the strategy are validated using historical data from Trift Glacier, where a lake formed over the past decade. Scenarios of future glacier lakes are shown for the two test regions Aletsch and Bernina in the Swiss Alps. In the Bernina region, potential future lake outbursts are modeled, using a GIS-based hydrological flow routing model. As shown by a corresponding test, the ASTER GDEM and the SRTM DEM are both suitable to be used within the proposed strategy. Application of this strategy in other mountain regions of the world is therefore possible as well.
Sleep restriction impairs maximal jump performance and joint coordination in elite athletes

ABSTRACT The study objective was to examine the effects of three days of sleep restriction on maximal jump performance and joint coordination. Eleven elite cyclists obtained a one-week baseline of habitual sleep then restricted sleep to 4 h/night (SR) for three nights assessed through self-report and actigraphy. Pre and post-intervention measures were a box drop maximal vertical jump with 3D motion capture to assess physical performance and biomechanical changes, and Psychomotor Vigilance Task (PVT) assessed changes in response time. Associations between biomechanical, physical, and cognitive performance measures were assessed. Participants restricted reported sleep from 7.4 ± 0.5 h/night at baseline to 4.0 ± 0.2 h/night and actigraphy indicated 6.7 ± 0.7 to 3.7 ± 0.2 h/night. Following SR, jump height decreased (0.44 ± 0.09 vs. 0.42 ± 0.10 m, p = 0.02, g = 0.21). Hip sagittal/knee frontal (Δ15.5°, p = 0.04, g = 0.40) and hip frontal/knee frontal (Δ11.0°, p < 0.01, g = 0.44) plane coordination variability increased after SR. Hip sagittal/knee frontal plane coordination variability after SR was associated with increasingly slower PVT response time (r = 0.63, p = 0.03). These findings suggest SR for three days decreased maximal jump performance. SR increased joint coordination variability and was associated with greater impairment in response time. SR leads to deviations from preferred movement patterns, which may have implications for decrements in athlete performance and increased injury risk.
Interaction effects in topological superconducting wires supporting Majorana fermions

Among the broad spectrum of systems predicted to exhibit topological superconductivity and Majorana fermions, one-dimensional wires with strong spin-orbit coupling provide one of the most promising experimental candidates. Here we investigate the fate of the topological superconducting phase in such wires when repulsive interactions are present. Using a combination of density matrix renormalization group, bosonization, and Hartree\char21{}Fock techniques, we demonstrate that while interactions degrade the bulk gap\char22{}consistent with recent results of Gangadharaiah et al.\char22{}they also greatly expand the parameter range over which the topological phase arises. In particular, we show that with interactions this phase can be accessed over a broader chemical potential window, thereby leading to greater immunity against disorder-induced chemical potential fluctuations in the wire. We also suggest that in certain wires strong interactions may allow Majorana fermions to be generated without requiring a magnetic field.
Endoplasmic Reticulum Detergent-Resistant Membranes Accommodate Hepatitis C Virus Proteins for Viral Assembly

During Hepatitis C virus (HCV) morphogenesis, the non-structural protein 2 (NS2) brings the envelope proteins 1 and 2 (E1, E2), NS3, and NS5A together to form a complex at the endoplasmic reticulum (ER) membrane, initiating HCV assembly. The nature of the interactions in this complex is unclear, but replication complex and structural proteins have been shown to be associated with cellular membrane structures called detergent-resistant membranes (DRMs). We investigated the role of DRMs in NS2 complex formation, using a lysis buffer combining Triton and n-octyl glucoside, which solubilized both cell membranes and DRMs. When this lysis buffer was used on HCV-infected cells and the resulting lysates were subjected to flotation gradient centrifugation, all viral proteins and DRM-resident proteins were found in soluble protein fractions. Immunoprecipitation assays demonstrated direct protein–protein interactions between NS2 and E2 and E1 proteins, and an association of NS2 with NS3 through DRMs. The well-folded E1E2 complex and NS5A were not associated, instead interacting separately with the NS2-E1-E2-NS3 complex through less stable DRMs. Core was also associated with NS2 and the E1E2 complex through these unstable DRMs. We suggest that DRMs carrying this NS2-E1-E2-NS3-4A-NS5A-core complex may play a central role in HCV assembly initiation, potentially as an assembly platform.
DISPERSION COMPENSATION USING ALL PASS FILTERS IN OPTICAL FIBERS

All pass filters (APFs) are used in dispersion compensation which is the foremost requirement in an optical fiber link. All pass filters can correct any order of dispersion by the careful design of multistage all pass filters starting from very simple components with the use of N port devices. Multiple channels, as in wavelength division multiplexed (WDM) system, can be compensated with a single device since these filters are periodic in phase response. The design technique and implementation of these filters has been discussed in this paper.
Kinase-Inactivated EGFR Is Required for the Survival of Wild-Type EGFR-Expressing Cancer Cells Treated with Tyrosine Kinase Inhibitors

Inhibiting the tyrosine kinase activity of epidermal growth factor receptor (EGFR) using small molecule tyrosine kinase inhibitors (TKIs) is often ineffective in treating cancers harboring wild-type EGFR (wt-EGFR). TKIs are known to cause dimerization of EGFR without altering its expression level. Given the fact that EGFR possesses kinase-independent pro-survival function, the role of TKI-inactivated EGFR in cancer cell survival needs to be addressed. In this study, using wt-EGFR-expressing cancer cells A549 (lung), DU145 (prostate), PC3 (prostate), and MDA-MB-231 (breast), we characterized the TKI-induced dimerization status of EGFR and determined the dependency of cells on kinase-inactivated EGFR for survival. We report that TKI-induced EGFR dimerization is dependent on palmitoylation and independent of its kinase activity, and that mutations of the cysteine residues known to be critical for EGFR’s palmitoylation abolished TKI-induced EGFR dimerization. Furthermore, TKI-induced EGFR dimerization is persistent in TKI-resistant cells, and inhibition of palmitoylation by 2-bromopalmitate, or targeted reduction of the kinase-inactivated EGFR by siRNA or by an EGFR-downregulating peptide, are lethal to TKI-resistant cancer cells. This study suggests that kinase-inactivated EGFR remains to be a viable therapeutic target for wt-EGFR cancers and that inhibiting palmitoylation or downregulating EGFR may overcome TKI resistance.
Acoustic Indoor Localization System Integrating TDMA+FDMA Transmission Scheme and Positioning Correction Technique

This paper presents a novel audio indoor localization system. In the proposed system, four speakers placed at known positions transmit chirp signals according to the time-division multiple access (TDMA) plus frequency-division multiple access (FDMA) transmission scheme. A smartphone receives the signal via a built-in microphone and calculates the time differences of arrival (TDOAs). Using TDOA measurements, the position is estimated by the shrinking-circle method. In particular, to reduce the positioning error in moving conditions, a TDOA correction method based on Doppler shifts is proposed. The performance of the proposed system was evaluated in real-world experiments using a 10.971 m × 5.684 m positioning area. The results of the static-target positioning experiment showed that the TDMA+FDMA transmission scheme has more advantages in improving the update rate of the positioning system than the TDMA-only transmission scheme. The results of the moving-target positioning experiment under three different speeds demonstrated that the positioning errors were reduced by about 10 cm when the Doppler-shift-based TDOA correction method was adopted. This research provides a possible framework for the realization of a TDOA-chirp-based acoustic indoor positioning system with high positioning accuracy and update rate.
Copy number variations and polymorphisms in HSP90AB1 and risk of systemic lupus erythematosus and efficacy of glucocorticoids

The aim of our study was to assess the associations of HSP90AB1 copy number variations (CNVs) with systemic lupus erythematosus (SLE) risk and glucocorticoids (GCs) efficacy, as well as the relationship between HSP90AB1 single‐nucleotide polymorphisms (SNPs) and GCs efficacy. HSP90AB1 CNVs and SLE risk were analysed in 519 patients and 538 controls. Patients treated with GCs were followed up for 12 weeks and were divided into sensitive and insensitive groups to investigate the effects of CNVs (419 patients) and SNPs (457 patients) on the efficacy of GCs. Health‐related quality of life (HRQoL) was also measured by SF‐36 at baseline and week 12 to explore the relationship between CNVs/SNPs and HRQoL improvements in Chinese SLE patients. Our results indicated a statistically significant association between HSP90AB1 CNVs and SLE (PBH = 0.039), and this association was more pronounced in the female subgroup (PBH = 0.039). However, we did not detect association of HSP90AB1 CNVs/SNPs with efficacy of GCs. But we found a marginal association between SNP rs13296 and improvement in Role‐emotional, while this association was not strong enough to survive in the multiple testing corrections. Collectively, our findings suggest that the copy number of HSP90AB1 is associated with SLE susceptibility. But copy number and polymorphisms of HSP90AB1 may not be associated with efficacy of GCs.
Targeting the Dark Horse of complement: the first generation of functionally selective C5aR2 ligands Strapline: Functionally selective C5aR2 ligands discovery

Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections.
Evaluation of Resistance to Different Insecticides and Metabolic Detoxification Mechanism by Use of Synergist in the Common Bed Bug (Heteroptera: Cimicidae)

Abstract Bed bugs have become a common urban pest with consequences on human health and economic costs to the hotel and tourism sectors. Insecticide resistance is considered an important factor in the current bed bug resurgence, and multiple resistance mechanisms could be working in the resistant bed bug populations. In the present study, we determined the resistance profile to four insecticides with a different mode of action in Cimex lectularius L. (Heteroptera: Cimicidae) field-collected colonies from Argentina. Furthermore, the synergism effect of piperonyl butoxide (PBO) with deltamethrin was investigated to explore the contribution of detoxification metabolism to resistance. Our results showed that most of the field-collected colonies are extremely resistant to deltamethrin and propoxur, much more than to azametiphos and imidacloprid. The differences in resistance ratios among field-collected colonies could be associated with different modes of action of insecticides used in control pest and the mechanisms involved in the resistance. PBO pretreatment led to a significantly decreased RR in pyrethroid-resistant colonies, suggesting an upturn of monooxygenase activity for deltamethrin detoxification. However, the high RR detected could involve other mechanisms as part of the whole resistant phenotype in colonies of C. lectularius resistant to pyrethroids.
EnImpute: imputing dropout events in single-cell RNA-sequencing data via ensemble learning

SUMMARY Imputation of dropout events that may mislead downstream analyses is a key step in analyzing single-cell RNA-sequencing (scRNA-seq) data. We develop EnImpute, an R package that introduces an ensemble learning method for imputing dropout events in scRNA-seq data. EnImpute combines the results obtained from multiple imputation methods to generate a more accurate result. A Shiny application is developed to provide easier implementation and visualization. Experiment results show that EnImpute outperforms the individual state-of-the-art methods in almost all situations. EnImpute is useful for correcting the noisy scRNA-seq data before performing downstream analysis. AVAILABILITY AND IMPLEMENTATION The R package and Shiny application are available through Github at https://github.com/Zhangxf-ccnu/EnImpute. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Estimation of Fingerprint Orientation field by utilizing Prior Knowledge and Self-Organizing Map

This study proposes a new method of estimating fingerprint orientation field by utilizing prior knowle dge of fingerprint images and Self-Organizing Map (SOM). The method is based on the assumption that fingerpri nt images have some common properties that can be systematized to build prior knowledge. In this method, each fingerprint image was divided into 16 regions equal ly and the regions were analyzed separately. To ana lyze the regions, they were divided into blocks of 8x8 pixel s. Feature vector of each block was constructed by summing the pixel intensity values in row and column wise. Furthermore, feature vectors of the blocks were con catenated to form a feature matrix of the region. The matrix was then processed by SOM to find the most dominant orientation field of the region. The experiment res ults showed that the chosen feature gave short epoc hs of SOM training. In addition, the method was able to estim ate the orientation field of most regions. However, the method could not precisely determine the orientation field if the blocks are dominated by background pixels.
The Typology of Voicing and Devoicing

This article provides empirical evidence against the claims that [voice] is a privative feature and that word-internal devoicing can occur in a language without word-final devoicing. The study of voice patterns in a number of languages shows that the feature value [-voice] although it is the unmarked value of the laryngeal feature [voice], can be active phonologically in a fashion parallel to the marked value [+ voice]. Across languages, voice assimilation may occur independently of devoicing and, although it normally affects both [+ voice] and [-voice], it may affect only one value in some languages.
Challenges of emerging memory and memristor based circuits: Nonvolatile logics, IoT security, deep learning and neuromorphic computing

Emerging nonvolatile memory (NVM) devices are not limited to build nonvolatile memory macros. They can also be used in developing nonvolatile logics (nvLogics) for nonvolatile processors, security circuits for the internet of things (IoT), and computing-in-memory (CIM) for artificial intelligence (AI) chips. This paper explores the challenges in circuit designs of emerging memory devices for application in nonvolatile logics, security circuits, and CIM for deep neural networks (DNN). Several silicon-verified examples of these circuits are reviewed in this paper.
Anemia and Transfusion in Critical Care

Objective: The objective of this report is to review the physiology and management of anemia in critical care. Selected publications on physiology and transfusion related to anemia and critical care, including the modern randomized trials of conservative versus liberal transfusion policy, were used. Anemia is compensated and tolerated in most critically ill patients as long as oxygen delivery is at least twice oxygen consumption. There are risks to blood transfusion which can be minimized by blood banking practice. The availability of cultured red cells may allow correction of anemia without significant risk. The benefit of transfusion in anemia must be weighted against the risk in any specific patient. Conclusion and Recommendation: In a criticially ill patient, anemia should be managed to avoid oxygen supply dependency (oxygen delivery less than twice comsumption) and to maintain moderate oxygen delivery reserve (DO2/VO2 > 3).
The rise and spread of mcr plasmid-mediated polymyxin resistance

Abstract Polymyxins are important lipopeptide antibiotics that serve as the last-line defense against multidrug-resistant (MDR) Gram-negative bacterial infections. Worryingly, the clinical utility of polymyxins is currently facing a serious threat with the global dissemination of mcr, plasmid-mediated polymyxin resistance. The first plasmid-mediated polymyxin resistance gene, termed as mcr-1 was identified in China in November 2015. Following its discovery, isolates carrying mcr, mainly mcr-1 and less commonly mcr-2 to -7, have been reported across Asia, Africa, Europe, North America, South America and Oceania. This review covers the epidemiological, microbiological and genomics aspects of this emerging threat to global human health. The mcr has been identified in various species of Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Salmonella enterica, Cronobacter sakazakii, Kluyvera ascorbata, Shigella sonnei, Citrobacter freundii, Citrobacter braakii, Raoultella ornithinolytica, Proteus mirabilis, Aeromonas, Moraxella and Enterobacter species from animal, meat, food product, environment and human sources. More alarmingly is the detection of mcr in extended-spectrum-β-lactamases- and carbapenemases-producing bacteria. The mcr can be carried by different plasmids, demonstrating the high diversity of mcr plasmid reservoirs. Our review analyses the current knowledge on the emergence of mcr-mediated polymyxin resistance.