Miracle-dz/UniFAR-FTUs huggingface dataset:
Previsão de Consumo de Energia Elétrica e do Preço da Eletricidade através de Redes Neuronais de Regressão Generalizada

Um dos principais desafios impostos para o seculo \textit{XXI} passa por realizar uma gestao coordenada e adequada do mercado da eletricidade e a consequente cooperacao com a producao de energia, permitindo integrar ferramentas computacionais que sustentem um setor eletrico viavel, eficaz e oportuno.O preco da eletricidade e o consumo energetico vem cada vez mais a representar dois grandes pilares do setor eletrico, com a sua analise e previsao a ser uma peca de capital importância para a estavel manutencao de um mercado que agora e liberalizado. Com a liberalizacao do mercado da eletricidade, a previsao de precos e consumo torna-se fundamental para desenvolver tomadas de decisao e para estabelecer estrategias por parte dos operadores de mercado. Ainda que, pela analise do preco da eletricidade, se revelem situacoes monetariamente estaveis, sobressaem-se tambem cenarios repletos de irregularidades e dai uma resultante dificuldade em estimar os precos, que podem penalizar o desempenho global da previsao. O consumo de energia, por sua vez, impoe curvas que refletem uma robustez caracteristica, e que permitem realizar previsoes satisfatoriamente elaboradas.No âmbito da presente dissertacao, pretende-se realizar a previsao de preco da eletricidade e do consumo, onde e imperativo o uso de redes neuronais artificiais (ANN). Ora, pretende-se verificar a significância de diversos tipos de ANN, uma rede neuronal \textit{feed-forward} convencional e uma rede neuronal de regressao generalizada (GRNN). Tendo como referencia valores obtidos pela analise classica de series temporais (Box-Jenkins), pretende-se comparar os diferentes tipos de redes neuronais quanto, por exemplo, a sua capacidade de resposta a flutuacoes, desempenho global ou ate tempos de treino.Importa claro, ter em consideracao uma coordenacao fiel das diferentes variaveis a estudar, ate porque a representacao de um modelo final de previsao deve ter em consideracao apenas aquelas que de facto apoiam de uma forma firme a previsao do preco da eletricidade ou do consumo.A abordagem pelas GRNN e uma solucao antiga (1991), mas tem ressurgido recentemente realcando um bom desempenho, rapidez da fase de treino e facilidade de parametrizacao. A integracao deste modelo em estudos comparativos com metodos mais convencionais permite obter solucoes sensatas em areas mais robustas com tempos de treino bastante reduzidos o que, mesmo representando um parâmetro de avaliacao cabal, pode, em diversos cenarios, ser providencial.
The Merit of Alternative Messenger RNA Splicing as a New Mine for the Next Generation Ovarian Cancer Biomarkers

Ovarian cancer is a low incidence cancer with high mortality rate [1]. The asymptomatic na‐ ture of this cancer and the late stage diagnosis of most tumors are the reasons for ineffective surgery and chemotherapy [2]. In this sense, intensive research aim at increasing overall pa‐ tient survival and quality of life by providing biomarkers for 1) early detection and 2) pre‐ diction of chemotherapy response and/or suggestion of alternative strategies. CA-125 is a glycoprotein that is usually expressed in a variety of epithelial cells and its serum level rise up in advance ovarian cancer [3]. However, its use as an early detection marker or as a tool to screen the general population has not been approved so far [4,5]. CA-125 level is helpful in treatment-decision making but do not retain the capacity to improve overall survival and quality of life [6,7]. Clearly, there is still great need for biomarkers or combination of bio‐ markers that could positively identify early ovarian cancer lesions with great certainty or in‐ crease patients’ survival.
Extraskeletal myxoid chondrosarcoma of the external auditory meatus

Extraskeletal myxoid chondrosarcoma (EMC) is an uncommon but distinct entity with clearly different clinicopathological, immunohistochemical, cytogenetical and histogenetical features from conventional skeletal chondrosarcoma. Because of its better prognosis in comparison to conventional skeletal chondrosarcoma, the right diagnosis is essential. A case of EMC occuring in the external auditory meatus, coexistent with in situ squamous carcinoma of the covering epithelium is being presented. This is the first report of this tumor coexistence.
A supercompiler system based on the language REFAL

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Functional correlates of cognitive dysfunction in multiple sclerosis: A multicenter fMRI Study

In this multicenter study, we applied functional magnetic resonance imaging (fMRI) to define the functional correlates of cognitive dysfunction in patients with multiple sclerosis (MS). fMRI scans during the performance of the N‐back task were acquired from 42 right‐handed relapsing remitting (RR) MS patients and 52 sex‐matched right‐handed healthy controls, studied at six European sites using 3.0 Tesla scanners. Patients with at least two abnormal (<2 standard deviations from the normative values) neuropsychological tests at a standardized evaluation were considered cognitively impaired (CI). FMRI data were analyzed using the SPM8 software, modeling regions showing load‐dependent activations/deactivations with increasing task difficulty. Twenty (47%) MS patients were CI. During the N‐back load condition, compared to controls and CI patients, cognitively preserved (CP) patients had increased recruitment of the right dorsolateral prefrontal cortex. As a function of increasing task difficulty, CI MS patients had reduced activations of several areas located in the fronto‐parieto‐temporal lobes as well as reduced deactivations of regions which are part of the default mode network compared to the other two groups. Significant correlations were found between abnormal fMRI patterns of activations and deactivations and behavioral measures, cognitive performance, and brain T2 and T1 lesion volumes. This multicenter study supports the theory that a preserved fMRI activity of the frontal lobe is associated with a better cognitive profile in MS patients. It also indicates the feasibility of fMRI to monitor disease evolution and treatment effects in future studies. Hum Brain Mapp 35:5799–5814, 2014. © 2014 Wiley Periodicals, Inc.
Impact of biomarkers, proteomics, and genomics in cardiovascular disease.

This special issue of Clinical Chemistry provides a comprehensive perspective into the current and future impact of biomarkers, proteomics, and genomics in cardiovascular disease. The growth in both the clinical use and new investigations of biomarkers, whether proteomic or genomic, has been explosive over the past 10 years. Protein biomarkers have been anchored by interdisciplinary guidelines (laboratory medicine, cardiology, emergency medicine, and epidemiology) that have provided international acceptance of cardiac troponin as the standard biomarker for use in the diagnosis and management of patients with acute coronary syndrome. In an additional paradigm shift, natriuretic peptides have come to be accepted for use in the diagnosis, management, and risk assessment of heart failure patients. More recently, the role of genomics has been shown by the introduction of basic-science findings into clinical practice, a trend that will only continue …
Biophysical Characterization of the Stability of the 150-Kilodalton Botulinum Toxin, the Nontoxic Component, and the 900-Kilodalton Botulinum Toxin Complex Species

ABSTRACT Botulinum neurotoxin serotype A is initially released from the bacterium Clostridium botulinum as a stable 900-kDa complex. The serotype A 900-kDa complex is one of the forms of the toxin being used as a therapeutic agent for the treatment of various neuromuscular disorders. Previous experiments have demonstrated that the 900-kDa complex form of the toxin protects the toxin from the harsh conditions of the gastrointestinal tract. To provide molecular level details of the stability and equilibrium of the 900-kDa complex, the nontoxic component, and the toxic (botulinum neurotoxin) component, the three species have been investigated with a series of biophysical techniques at the molecular level (dynamic light scattering, proteolysis, circular dichroism, pH incubations, and agglutination assays). These experiments were conducted under harsh conditions which mimic those found along the gastrointestinal tract. Separately, exposure to denaturing and proteolytic conditions degrades both the botulinum neurotoxin and the nontoxic component. In the 900-kDa complex, the botulinum neurotoxin is protected during exposure to the gastrointestinal environment and the nontoxic component is slightly modified. Surprisingly, the toxin protects the ability of the nontoxic component to agglutinate erythrocytes. Contrary to previous reports, the purified 900-kDa complex did not have agglutination ability until after exposure to the proteolytic conditions. These experiments provide new evidence and detail for the theory that the nontoxic component and the toxic component protect one another during exposure to harsh conditions, and a molecular model is presented for the passage of the toxin through the gastrointestinal tract.
Facial Expression Analysis with Kinect for the Diagnosis of Paralysis Using Nottingham Grading System

Facial palsy is a neuromuscular disorder caused by damage to motor and sensory pathways of the facial nerve, which causes a movement disorder in the facial muscles. In clinical diagnosis of facial nerve palsy, simple and quantitative assessment of facial motion is strongly required. A systematic evaluation of facial nerve paralysis allows the clinician to determine objectively the severity of disability and record this information, in order to evaluate the response to therapy. The proposed method evaluates the degree of facial paralysis by using Kinect as a feature extraction tool and Nottingham grading system. The proposed grading system measure the distance between the eyebrows to infra orbital and the distance between the edges of mouth and lateral canthus. We divided the grading scale into three levels: normal, mild and severe by using the estimated parameters.
Linear Multistep Methods for Impulsive Differential Equations

This paper deals with the convergence and stability of linear multistep methods for impulsive differential equations. Numerical experiments demonstrate that both the mid-point rule and twostep BDF method are of order p � 0 when applied to impulsive differential equations. An improved linear multistep method is proposed. Convergence and stability conditions of the improved methods are given in the paper. Numerical experiments are given in the end to illustrate the conclusion.
Evaluation of Lamination Micro Mixer for Micro Immunomagnetic Cell Sorter

A split-and-recombine lamination mixer for mu-immunomagnetic cell sorting system has been developed for extracting stem cells from peripheral blood. Cell suspension is mixed with antibody-coated magnetic beads, and target cells are labeled with antigen-antibody reaction. In this report, the mixer performance is evaluated quantitatively by using human umbilical vein endothelial cells (HUVEC). The number of magnetic beads attached to the target cell is evaluated in two different arrangements of the mixer units
Question Answering System with Bi-Directional Attention Flow

For the Assignment 4 of CS 224n course, we did a reimplementation of the BiDirectional attention flow model (BiDAF). We built the architecture from scratch, tuned the network and tried different regularization and out-of-vocabulary handling strategies. Eventually, we are able to get F1 score 76.5 and EM 66.3 on test set with our ensemble model of five single models.
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

The expression of activation-induced cytidine deaminase (AID) is prerequisite to a “trifecta” of key molecular events in B cells: class-switch recombination and somatic hypermutation in humans and mice and gene conversion in chickens. Although this critically important enzyme shares common sequence motifs with apolipoprotein B mRNA-editing enzyme, and exhibits deaminase activity on free deoxycytidine in solution, it has not been shown to act on either RNA or DNA. Recent mutagenesis data in Escherichia coli suggest that AID may deaminate dC on DNA, but its putative biochemical activities on either DNA or RNA remained a mystery. Here, we show that AID catalyzes deamination of dC residues on single-stranded DNA in vitro but not on double-stranded DNA, RNA–DNA hybrids, or RNA. Remarkably, it has no measurable deaminase activity on single-stranded DNA unless pretreated with RNase to remove inhibitory RNA bound to AID. AID catalyzes dC → dU deamination activity most avidly on double-stranded DNA substrates containing a small “transcription-like” single-stranded DNA bubble, suggesting a targeting mechanism for this enigmatic enzyme during somatic hypermutation.
Microdialysis perfusion of 5‐HT into hypoglossal motor nucleus differentially modulates genioglossus activity across natural sleep‐wake states in rats

1 Serotonin (5‐hydroxytryptamine, 5‐HT) excites hypoglossal (XII) motoneurons in reduced preparations, and it has been suggested that withdrawal of 5‐HT may underlie reduced genioglossus (GG) muscle activity in sleep. However, systemic administration of 5‐HT agents in humans has limited effects on GG activity. Whether 5‐HT applied directly to the XII motor nucleus increases GG activity in an intact preparation either awake or asleep has not been tested. 2 The aim of this study was to develop a novel freely behaving animal model for in vivo microdialysis of the XII motor nucleus across sleep‐wake states, and test the hypothesis that 5‐HT application will increase GG activity. 3 Eighteen rats were implanted with electroencephalogram and neck muscle electrodes to record sleep‐wake states, and GG and diaphragm electrodes for respiratory muscle recording. Microdialysis probes were implanted into the XII motor nucleus and perfused with artificial cerebrospinal fluid (ACSF) or 10 mm 5‐HT. 4 Normal decreases in GG activity occurred from wakefulness to non‐rapid eye movement (non‐REM) and REM sleep with ACSF (P < 0.01). Compared to ACSF, 5‐HT caused marked GG activation across all sleep‐wake states (increases of 91‐251 %, P < 0.015). Importantly, 5‐HT increased sleeping GG activity to normal waking levels for as long as 5‐HT was applied (3‐5 h). Despite tonic stimulation by 5‐HT, periods of phasic GG suppression and excitation occurred in REM sleep compared with non‐REM. 5 The results show that sleep‐wake states differentially modulate GG responses to 5‐HT at the XII motor nucleus. This animal model using in vivo microdialysis of the caudal medulla will enable the determination of neural mechanisms underlying pharyngeal motor control in natural sleep.
General Source-Channel Matching for Sources with Memory

In this paper we analyze the probabilistic matching of sources to channels so that symbol-by-symbol code transmissions with memory without anticipation are optimal, with respect to an average distortion and excess distortion probability. We show achievability of such a symbol-by-symbol code with memory without anticipation, and we show matching for the Binary Symmetric Markov source (BSMS(p)) over a first-order symmetric channel with a power constraint.
Photosynthetic Pigments of Green Sulfur Bacteria

Bacteriochlorophyll c, the light-harvesting pigment from the green sulfur bacteria Chlorobium limicola, has been resolved into over a dozen chemically similar components by a new high pressure reversed-phase chromatographic procedure based on a stationary phase of polyethylene powder. Detailed spectroscopic characterization of the resolved components has resulted in the identification of four different chlorins and six different esterifying alcohols. The major esterifying alcohol is trcms, trans-farnesol, but smaller amounts of geranylgeraniol, tetrahydrogeranylgeraniol, phytol, cis-9-hexadecen-l-01 and 4-undecyl-2-furanmethanol are also observed. The high information content intrinsic in the compositional analyses of the complex pigment mixtures found in green sulfur bacteria appears to provide a new probe of the mechanisms of pigment biosynthesis in these organisms.
Frequency-dependent Cardiac Electrophysiologic Effects of Tedisamil: Comparison With Quinidine and Sotalol

Background: Tedisamil is a potent bradycardic/antiischemic drug known to lengthen car diac repolarization by blocking various potassium channels. Recent in vivo experiments revealed that it is an antiarrhythmic agent. It was therefore of interest to compare the cellu lar electrophysiologic effects of tedisamil with those of quinidine and sotalol in isolated car diac preparations. Methods and Results: The conventional microelectrode technique was applied in isolated dog cardiac Purkinje and ventricular muscle fibers and in rabbit left atrial muscle. Tedisamil (1 μM) and sotalol (30 μM) lengthened, while quinidine (10 μM) shortened action potential duration in dog Purkinje fibers. The phase 1 repolarization was delayed by tedisamil and quinidine and not changed by sotalol. In dog ventricular muscle and in rabbit atrial muscle, all three drugs studied lengthened repolarization. In dog Purkinje fiber, tedisamil and sotalol lengthened action potential duration more at slow than at high stimulation frequency (reverse use-dependence). In dog ventricular muscle fibers, the effect of the drugs was not clearly fre quency dependent. In rabbit atrial muscle fibers, the quinidine-evoked repolariration length ening was most pronounced at intermediate cycle lengths (500-1000 ms). Tedisamil and quinidine but not sotalol depressed the maximal rate of depolarization (Vmax), which depended on the stimulation frequency (use-dependence). The nature of the use-dependent Vmax block differed between quinidine and tedisamil. Quinidine decreased Vmax at a relatively wide range of stimulation frequencies while tedisamil decreased Vmax largely at high rate of stimulation. Tedisamil and quinidine prevented or decreased the pinacidil-evoked action potential shortening in dog ventricular muscle, suggesting block of the ATP-dependent potas sium channels (IKATP), while with sotalol such effect was not observed. Conclusions: Although tedisamil, quinidine. and sotalol are known to lengthen the QT inter val, their cellular electrophysiologic effects substantially differ. Tedisamil lengthens repolar ization and prevents pinacidil-evoked action potential duration shortening, suggesting IK(ATP) blockade. Its effect on the Vmax is limited mostly to fast heart rate. These electrophysiologic effects of tedisamil resemble those of chronic amiodarone treatment.
Linked file system: Towards exploiting linked data technology in file systems

Most of the file systems today are based on desktop metaphor utilizing hierarchies of folders and sub-folders for information storage and retrieval. A folder is usually assumed to store the semantically related information in the form of files and sub-folders. However, there always exist related files somewhere else in the local file system hierarchy. Users often fail to find these disconnected files or discover the relationship among these. File systems maintain a plain set of metadata items about each file which could be utilized to discover some of the hidden relationships. However, this meta-information is very sparse as most of this metadata is rarely entered by the user. Moreover, files in a file system are mostly private and cannot get the benefit of collaborative tagging. Web of Data, on the other hand also contains information related to the file system objects which could be utilized for linking with information in file systems. The purpose of introducing Linked Data technology was to solve similar issues on the web. This article investigates the exploitation of Linked Data technology in file systems and provides a comprehensive review on the possible use of Linked Data Technology in file systems.
Cellular and molecular mechanisms of asbestos‐induced fibrosis

Pleural and pulmonary fibrosis (asbestosis) are ramifications of occupational exposures to asbestos fibers, a diverse family of ubiquitous, naturally‐occurring minerals. The pathogenesis of asbestos‐associated fibrosis involves the participation of a number of cell types and is characterized by an early and persistent inflammatory response that involves the generation of oxidants, growth factors, chemokines, and cytokines. These mediators may also contribute directly to cell injury, proliferation, and fibrogenesis. After interaction with cells, asbestos fibers trigger a number of signaling cascades involving mitogen‐activated protein kinases (MAPK) and nuclear factor kappa‐B (NF‐κB). Activation of transcription factors such as NF‐κB and activator protein‐1 (AP‐1) may be linked to increases in early response genes (e.g., c‐jun and c‐fos) which govern proliferation, apoptosis, and inflammatory changes in the cells of the lung. The goal of this article is to review the cellular and molecular mechanisms of asbestos‐induced fibrosis that may be critical to the development of effective treatment regimens. J. Cell. Physiol. 180:158–166, 1999. © 1999 Wiley‐Liss, Inc.
Equalization system for serially-connected battery cells based on the wave-trap concept

The use of battery cell equalizers is mandatory in order to assure that all the cells connected in series are charged to its maximum capacity, even when they present small differences in this parameter due to several factors, such as aging, manufacturing or temperature. Active equalizers, with a higher efficiency in comparison to passive ones, have the disadvantage of using a considerable number of components. Moreover, in the case of active equalizers with very high performance, this number can be even higher. In this paper, the use of the wave-trap concept, widely used in telecommunication systems, is studied. This concept allows the battery cell equalizer to use its switching frequency as the control variable that decides which cell is being charged. Hence, it is not necessary to use a complex system based on a high number of controlled switches in order to determine which cell is being charged. In this way, the number of switches (and the corresponding driving signals) can be strongly minimized without reducing the performance of the system. In order to proof the validity of this concept (i.e., wave traps) in the design of battery-cell equalizers, a topology based on a half-bridge structure is also proposed in this paper. It uses only two controlled switches in order to decide which cell is charged. Experimental results are provided for a 4-cell equalizer as a proof of concept.