Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing Child Postural Variability: Development, Feasibility, and Reliability of a Video Coding System

Abstract Aims Postural variability is central to children’s locomotion, motor control, and environmental exploration, and lacks standardized methods for systematic assessment. The purpose of this study was to develop and evaluate the feasibility and interrater reliability of Child Posture Variability Coding (CPVC), a method of quantifying postural variability in young children. Method Videos of parent-child play interactions obtained from a longitudinal study investigating language acquisition in typically developing (TD) children and children with autism spectrum disorder (ASD) were used to develop 33 codes for children’s voluntary changes in static and dynamic postures. Interrater reliability was calculated for three raters who independently coded 10 randomly selected videos of children aged 23 to 48 months (TD: n = 5, median = 35, IQR = 12.5; ASD: n = 5, median = 35, IQR = 6.75). Results Overall, CPVC demonstrated excellent interrater reliability (Krippendorff’s > 0.90). Among all codes developed, five codes (i.e., sit–half, sit–other, crawl, cruise, and supported walk) were not observed by any coders in the sample, but were kept in the coding scheme to reflect normal developmental milestones. Conclusions CPVC is a reliable, feasible method of quantifying postural variability in young children with and without neurodevelopmental disorders in naturalistic contexts.
Trichoplax adhaerens: Discovered as a missing link, forgotten as a hydrozoan, re-discovered as a key to metazoan evolution

L'organisation de Trichoplax adhaerens est plus simple que celle des autres metazoaires vivants. Decrit par F E Schulze en 1883, cet organisme attirait l'attention des scientifiques qui pensaient d'abord que son organisation pourrait representer un etat basal et ancestral pour les metazoaires. Mais par la suite les zoologistes et les biologistes de l'evolution delaisserent ce modele, et durant plus d'un demi-siecle, Trichoplax passa pour une larve planula aberrante d'un Hydrozoaire. Recemment cet organisme a ete redecouvert en tant qu'espece cle pour la comprehension de l'evolution precoce des metazoaires. Les genes Hox et le sequencage complet du genome devraient permettre d'aborder la genetique sous-jacente qui pourrait elucider l'origine et le developpement des grands embranchements de metazoaires. Nous passons en revue l'histoire des recherches consacrees a Trichoplax et proposons une interpretation moderne des caracteres particuliers de Trichoplax places dans un contexte evolutif.
Genetic Analysis Shows that Morphology Alone Cannot Distinguish Asian Carp Eggs from Those of Other Cyprinid Species

AbstractFish eggs and embryos (hereafter collectively referred to as “eggs”) were collected in the upper Mississippi River main stem (~300 km upstream of previously reported spawning by invasive Asian carp) during summer 2013. Based on previously published morphological characteristics, the eggs were identified as belonging to Asian carp. A subsample of the eggs was subsequently analyzed by using molecular methods to determine species identity. Genetic identification using the cytochrome-c oxidase 1 gene was attempted for a total of 41 eggs. Due to the preservation technique used (formalin) and the resulting DNA degradation, sequences were recovered from only 17 individual eggs. In all 17 cases, cyprinids other than Asian carp (usually Notropis sp.) were identified as the most likely species. In previously published reports, a key characteristic that distinguished Asian carp eggs from those of other cyprinids was size: Asian carp eggs exhibited diameters ranging from 4.0 to 6.0 mm and were thought to be m.
Evaluation of ReachOut.com, an Unstructured Digital Youth Mental Health Intervention: Prospective Cohort Study

Background Young people experience a disproportionate burden associated with mental illness that Australia’s mental health care system is ill-equipped to handle. Despite improvements in the provision of mental health services, the rates of service utilization among young people remain suboptimal, and there are still considerable barriers to seeking help. Digital mental health services can overcome a number of barriers and connect young people requiring support; however, the evidence base of digital interventions is limited. Objective The aim of this study is to examine the effectiveness of a brief, self-directed, unstructured digital intervention, ReachOut.com (hereafter ReachOut), in reducing depression, anxiety, stress, and risk of suicide. Methods A cohort of 1982 ReachOut users participated in a 12-week longitudinal study, with a retention rate of 81.18% (1609/1982) across the duration of the study. Participants completed web-based surveys, with outcome measures of mental health status and suicide risk assessed at 3 time points across the study period. Results The results demonstrated that over the 12-week study period, young people using ReachOut experienced modest yet significant reductions in symptoms of depression, anxiety, and stress. Significant, albeit modest, reductions in the proportion of participants at high risk of suicide were also observed. Conclusions The findings of this research provide preliminary evidence of the promise of an unstructured digital mental health intervention, ReachOut, in alleviating symptoms of mental ill-health and promoting well-being in young people. These findings are particularly important given that digital services are not only acceptable and accessible but also have the potential to cater to the diverse mental health needs of young people at scale, in a way that other services cannot.
Persistent Interferon Production by Double Negative T Cells and Collapsing Focal Segmental Glomerulosclerosis

Collapsing glomerulopathy has multiple associations, including viral infections, medications like bisphosphonates and interferon, autoimmune diseases, and genetic predisposition. We report a case of collapsing focal segmental glomerulosclerosis associated with persistently high levels of interferon gamma produced by T-cell receptor αβ (+), CD4− CD8− (double negative) T lymphocytes that progressed despite treatment and improvement of other cytokine levels. Double negative T cells are elevated and activated in autoimmune lymphoproliferative syndrome (ALPS). Production of elevated interferon gamma levels from double negative T cells in ALPS despite treatment provides insight to the pathophysiology of collapsing glomerulopathy, guiding future research for collapsing glomerulopathy.
Does Aluminium Trigger Breast Cancer

Summary. Breast cancer is by far the most common cancer in women in the western world. In 90% of breast cancers, environmental factors are among the causes. The frequency with which the tumour occurs in the outer upper part of the breast has risen with above average rates in recent decades. Aluminium salts as ingredients in deodorants and antiperspirants are being absorbed by the body to a greater extent than hitherto assumed. Their toxicity for healthy and diseased breast tissue cells includes various well-documented pathomechanisms. In the sense of primary and secondary prevention, the cancer-triggering potential of aluminium and its use in anti-perspirant deodorants must be re-evaluated. For the same reason the access to a targeted diagnosis and treatment of aluminium loading must be facilitated.
Adaptive Event-Triggered Synchronization of Reaction–Diffusion Neural Networks

This article focuses on the design of an adaptive event-triggered sampled-data control (ETSDC) mechanism for synchronization of reaction–diffusion neural networks (RDNNs) with random time-varying delays. Different from the existing ETSDC schemes with predetermined constant thresholds, an adaptive ETSDC mechanism is proposed for RDNNs. The adaptive ETSDC mechanism can be promptly adaptively adjusted since the threshold function is based on the current sampled and latest transmitted signals. Thus, the adaptive ETSDC mechanism can effectively save communication resources for RDNNs. By taking the influence of uncertain factors, the random time-varying delays are considered, which belongs to two intervals in a probabilistic way. Then, by constructing an appropriate Lyapunov–Krasovskii functional (LKF), new synchronization criteria are derived for RDNNs. By solving a set of linear matrix inequalities (LMIs), the desired adaptive ETSDC gain is obtained. Finally, the merits of the adaptive ETSDC mechanism and the effectiveness of the proposed results are verified by one numerical example.
Prenatal Assessment of Atypical Adrenal Glands

The aim of this study was to identify specific unusual prenatal ultrasound (US) patterns of the adrenal gland and to propose a systematic approach for diagnosis. Six fetuses with unusual aspects of one or both adrenal glands, detected during routine prenatal US screening, were evaluated. Prenatal and postnatal management are described. A checklist of US features was created to perform a detailed analysis of adrenal lesions and guide prenatal management; this includes the time of appearance, location, growth, vascularization, structure, and presence of findings suggestive of malignancy.
From Plants to Animal Protein: Are Farmed Insects and Aquaculture Fish Less Competitive with Human Food Production than Traditional Livestock?

ix Samenvatting x Chapter 1: Introduction 11 1.1 Problem formulation 12 1.2 Research questions 14 Chapter 2: Development of aquaculture and insect farming 16 2.1 Aquaculture 16 2.1.1 Aquaculture species and production methods 16 2.1.2 Aqua feed 18 2.2 Insects 20 2.2.1 Insect farming 20 2.2.2 Insects as food 21 2.2. 3 Insects as feed 21 2.2. 4 Prospects and constraints 22 Chapter 3: Methodology 24 3.1 Analysed animal production systems and their comparison at the feed-consumption level. 24 3.2 Selection of published LCA studies 27 3.3 Comparison of LCA studies 32 3.3.1 Environmental impact and resource claim indicators 33 3.3.2 Feed-Food competition 34 3.3.3 Allocation in multi-output systems 37 3.4 Definition of alternative production methods in FeedPrint 39 3.5 Datasets on the production of feed ingredients in FeedPrint 40 Chapter 4: Results 46 4.1 Allocation methods 46 4.2 Alternative production methods 49 4.3 Multiple-indicator performance 51 4.4 Feed-food competition 53 Chapter 5: Discussion 58 5.1 Towards a food strategy? 59 5.2 Recommendations 59 5.3 Limitations and uncertainties of present study 61 Chapter 6: Conclusions 62 References xi List of abbreviations xiii Appendix A – Modelled animal production systems xiv Appendix B Animal production systems from published LCA studies xxix Appendix C – Farmed insects and production quantities xxxiv
On day admissions in neurosurgery: a comparative cohort study

Abstract Day of admission neurosurgery is a viable method to reduce health care associated costs, complications and length of stay. Within the national health service in England the picture is very mixed with some neurosurgery centres universally admitting patients the day before and others admitting on the day of surgery. We altered our admissions policy during a 4 month time period from ‘day-before’ surgery to ‘day-of’ surgery for elective neurosurgery. A number of patients still continued to be admitted the day before surgery due to consultant choice. We conducted a comparative cohort study of these two patient groups to see if there were any differences in surgical cancellation rates, the reasons for these cancellations and the implied cost savings. In total 199 patients underwent neurosurgery during this time period, 87 patients were admitted on the ‘day-of’ and 112 patients on the ‘day-before’ surgery. The overall cancellation rate was 18%. The cancellation rate in patients admitted on the ‘day-of’ surgery was 12.6% (11/87). The rate of cancellation in patients admitted the ‘day-before’ surgery was 22.3% (25/112). This difference was not significant (p = 0.1). Day of surgery admission resulted in a cost saving of almost £30,000 in this group of patients over a 4 month period. If extrapolated for all patients over the course of a year it would result in cost savings in the region of £150,000. In summary, admitting elective neurosurgery patients on the day of surgery does not affect cancellation rates, prevents unnecessary overnight hospital admission and results in significant cost saving.
Current update of first trimester preeclampsia screening in Asia

In consideration of high prevalence of preeclampsia, enormous studies attempted to look for strategies in early gestation. Hence, a powerful screening should be built up in first trimester. Then, Aspirin could be administrated for proper prevention. The objective of this article is reviewing the screening for preeclampsia in first trimester recently. To identify the high‐risk group precisely, an effective model should be recommended to Asian population. Articles related to first trimester screening of PE in Asia from databases of PubMed, ScienceDirect and Scopus were searched for this narrative review. The criteria included randomized clinical trials, observational prospective and retrospective cohort studies, case–control studies, systematic review and meta‐analysis and professional review articles. Screening models combining maternal factors, biophysical factors, ultrasound studies and biochemical factors achieved high predictive performance of preeclampsia. In Asia, the detection rate of the Fetal Medicine Foundation is superior to those of the American College of Obstetricians and Gynecologists and the National Institute for Health and Care Excellence . Consequently, this effective model from the Fetal Medicine Foundation should be continuously used for screening in first trimester for the Asian.
A MicroRNA Expression Signature as Prognostic Marker for Oropharyngeal Squamous Cell Carcinoma.

BACKGROUND Robust prognostic stratification of patients with oropharyngeal squamous cell carcinoma (OPSCC) may facilitate individualized patient management. This study was conducted to develop and validate a clinically feasible prognostic classifier based on microRNA sequencing (miRNA-seq) analysis. METHODS Tumor tissues were collected for miRNA-seq analysis from 324 OPSCC patients treated at Washington University in St. Louis and 130 OPSCC patients treated at Vanderbilt University, used for model training and validation, respectively. OPSCC patients (n = 79) from the TCGA were also included for independent validation. Univariate and multivariate Cox regression analyses were performed to identify miRNAs associated with disease outcomes. RESULTS A 26-miRNA signature was identified by miRNA-seq profiling analysis. Based on computed risk scores of the signature, we classified the patients into low- and high-risk groups. In the training cohort, the high-risk group had much shorter overall survival (OS) compared to the low-risk group [hazard ratio (HR) = 3.80, 95% CI = 2.37-6.10, P < . 001]. Subgroup analysis further revealed that the signature was prognostic for HPV-positive OPSCCs (HR = 3.07, 95% CI = 1.65-5.71, P < .001). Multivariate analysis indicated that the signature was independent of common clinicopathologic factors for OPSCCs. Importantly, the miRNA signature was a statistically significant predictor of OS in independent validation cohorts (TCGA cohort: HR = 6.05, 95% CI = 2.10-17.37, P < .001; Vanderbilt cohort: HR = 7.98, 95% CI = 3.99-15.97, P < .001; Vanderbilt HPV-positive cohort: HR = 8.71, 95% CI = 2.70-28.14, P < .001). CONCLUSION The miRNA signature is a robust and independent prognostic tool for risk stratification of OPSCCs including HPV-positive OPSCCs.
A revision of the Leptogium saturninum group in North America

Abstract A revision of the North American members of the Leptogium saturninum group (i.e. species with long lower-surface hairs, isidia, and usually smooth upper surface) is presented based on molecular phylogenetic analyses of mtSSU and nrITS sequence data, together with an extensive morphological study. Three species supported by both molecular and morphological characteristics are recognized: L. acadiense sp. nov. (distinguished by granular saturninum-type isidia, medulla composed of irregularly arranged or perpendicular hyphae), L. cookii sp. nov. (distinguished by cylindrical saturninum-type isidia) and L. hirsutum (distinguished by hirsutum-type isidia and medulla composed of loosely intertwined hyphae). One species supported by morphological characteristics, but for which no molecular data could be generated, is also recognized: L. compactum sp. nov. (distinguished by hirsutum-type isidia and medulla composed of tightly packed hyphae). Finally, L. saturninum (distinguished by granular saturninum-type isidia and medulla composed of perpendicular and parallel hyphae) is supported by morphological characteristics but molecular data from geographically diverse populations, including those near the type locality, indicate that the morphologically defined species is paraphyletic. Leptogium burnetiae is excluded from North American based on morphological study of the type. The species are described and illustrated in detail, and are distinguished morphologically by their isidium development, morphology of mature isidia, and pattern of hyphae in the medulla in transverse sections near lobe margins. A key to the members of the L. saturninum group and related species is also presented.
Pengaruh pemahaman metodologi penelitian terhadap penyelesaian proposal skripsi mahasiswa di Semester VIII Jurusan PAI Fakultas Tarbiyah IAIN Sunan Ampel Surabaya

Telah lulus mata kuliah metodologi penelitian menjadi salah satu syarat wajib bagi mahasiswa untuk menyusun skripsi, kendati demikian tidak sedikit kita jumpai mahasiswa yang kesulitan dan kebingungan dalam menyusun proposal skripsi. Bahkan tidak segan-segan mereka menambah semester hanya semata-mata untuk menyusun sebuah skripsi. Fenomena ini juga terjadi di WN Sunan Ampel Surabaya, khususnya di Fakultas Tarbiyah Jurusan PAL Berangkat dari permasalahan tersebut, maka penulis melakukan penelitian tentang "Pengaruh Pemahaman Metodologi Penelitian Terhadap Penyelesaian Proposal Skripsi Mahasiswa Di Semester VIII Jurusan PAI Fakultas Tarbiyah JAIN Sunan Ampel Surabaya". Dalam menjawab permasalahan tersebut, penulis melakukan penelitian dengan menggunakan metode "korelasional" yang memakai rumus prosentase untuk mengetahiu rumusan masalah pertama dan kedua. Adapun untuk mengetahui ada tidaknya korelasi antara rumusan masalah yang pertama dan kedua adalah menggunakan rumus "r" Product Moment. Sedangkan proses pengumpulan datanya menggunakan metode observasi, angket, dan dokumentasi. Dari penelitian yang telah dilakukan, bahwa pemahaman metodologi penelitian mahasiswa di semester VIII tergolong cukup baik (71,66%), dan penyelesaian proposal skripsinya tergolong cukup baik (64,66%). Hasil angket yang diberikan kepada 30 responden membuktikan tidak ada pengaruh antara pemahaman metodologi penelitian (variabel X) terhadap penyelesaian proposal skripsi (variabel Y). Hal ini terbukti dari hasil perhitungan rxy sebesar 0,224. Yang mana rxy tersebut nilainya lebih rendah baik pada taraf signifikan 5% maupun 1%. Jika dilihat dari tabel interpretasi product moment menunjukkan bahwa nilai rxy terletak diantara rentang 0,20 - 0,40 dengan rnempunyai nilai indeks korelasi yang lemah atau rendah.
Nesfatin-1 and neuronostatin neurons are co-expressed with glucocorticoid receptors in the hypothalamus

ABSTRACT Nesfatin-1 and neuronostatin in the central nervous system participate in regulating stress responses. Glucocorticoid hormones affect the brain through glucocorticoid receptors (GR). We investigated in the rat the possibility of co-localizing nesfatin-1 and neuronostatin neurons in hypothalamic areas with GR. using immunohistochemistry. We counted nesfatin-1 and neuronostatin stained neurons. We counted GR positive nesfatin-1 neurons in the arcuate nucleus (ARC) and paraventricular nucleus (PVN) and GR positive neuronostatin neurons in the periventricular nucleus (PeN). The percentage of nesfatin-1 neurons that expressed GR was 38.4% in female rats and 21.9% in male rats in the ARC, and 33.3% in female rats and 29.2% in male rats in the PVN. The percentage of neuronostatin neurons that expressed GR was 39.1% in female rats and 39.9% in male rats in the PeN. We found that a substantial portion of nesfatin-1 and neuronostatin neurons were stained for GR. We speculate that the pattern of GR might permit secretion of neuropeptides to be stimulated by peripheral glucocorticoid signals. Stress can suppress food intake, in part, through the GR in neurons that express nesfatin-1, which is a satiety molecule, and in neurons that express neuronostatin, which is an anorexigenic peptide.
Expression of Cytokines in Vaginal Secretion of Women with Yeast Colonization

Aim: Comparative analysis of local expression of IL-2, IL-10 and TNF- α was carried out to provide an insight to the extent and type of localized immune response associated with yeast colonization of the urogenital tract. Study Design: Descriptive Observational study. Place and Duration of the Study: University of Port Harcourt Teaching Hospital. January to June 2015. Methodology: Cytokines were assayed using standard ELISA techniques. Cytokine concentrations were compared across multiple groups by use of the Kruskal-Wallis and Dunn's posts’ tests. Results: There was a significantly elevated (p < 00.05) TNF- α concentration in women with yeast colonization (25.6 pg/ml) when compared to women with normal microbiota (22.2 pg/ml). There was also significant elevated level (p < 00.05) of average IL-10 concentrations in women with yeast infection (20.9 pg/ml) when compared to women with normal microbiota (14.8 pg/ml). However, there was no significant difference (p > 00.05) in the average IL-2 concentrations of women with yeast colonization and normal microbiota (10.4 pg/ml and 10.2 pg/ml respectively). Conclusion: The study showed a significant pro-inflammatory immune response to yeast colonization, with a minimal humoral mediated immune response and no hypersensitivity. The local expression of TNF- α and IL-10 increases with the extent of yeast cell colonization.