Miracle-dz/UniFAR-FTUs huggingface dataset:
Examination of Effects of Regular Sports Training on Individual Skills in Trainable Children with Autism.

The aim of this study is to examine the effects of regular sport training implemented at Integrated Disabled Athlete Department on autistic children’s adolescence development of individual abilities as motor proficiencies. The subject group of this study is composed of 12 boys with autism who practiced physical education programs in running speed and agility, balance, coordination, and strength for 13 weeks. They were trained for one hour a day and for three days a week. In order to analyse the result of that training program, both preliminary and post-test techniques and particularly Bruininks-Oseretsky Test of Motor (2nd ed.) (BOT-2) were implemented. The result of preliminary and post-tests showed that there is a significant difference between motor levels (running speed and agility, balance, coordination, and strength). This result was interpreted that physical education has positive effects on the subjects. As a result, regular sports training provided to children with autism were found to promote the development of physical properties.
[Hepatitis B virus X protein induces malignant transformation tendency of Chang liver cells involving p16(INK4a) hypermethylation].

OBJECTIVE To study the relationship between hepatitis B virus X (HBx) protein and DNA methylation of p16(INK4a) and the role of HBx in the carcinogenesis of hepatocellular carcinoma. METHODS Eukaryonic expression vectors pcDNA3.1B-HBx and pcDNA3.1B were transduced into Chang liver cells by using Lipofectamine 2000 to establish the Chang-HBx liver cell line (HBx expression) and Chang-vector liver cell line (non-HBx expression). RT-PCR and Western blot were used to test the expression of p16(INK4a) in the two cell lines. The level of p16(INK4a) promoter methylation was tested by methylation specific PCR (MSP). The proliferation curves were drew by CCK-8, and S-phase in cell cycle and apoptosis were observed by flow cytometry. RESULTS Hypermethylation of p16 can be mediated by HBx, which decreases the expression of mRNA and protein of p16. Chang-HBx cells grow faster. Chang-HBx cells have much higher S-phase population (28.96% vs. 21.53%, P<0.001; 28.96% vs. 21.5%, P<0.001) and lower apoptosis rate (2.71% vs. 3.69%, P<0.001; 2.71% vs. 3.36%, P<0.001) than Chang-vector cells and Chang cells respectively. CONCLUSION p16(INK4a) expression was repressed by HBx protein via DNA methylation of p16(INK4a), which can induce the malignant transformation tendency of Chang cells.
Evaluating Individual and Group Experiential Learning in Scrum and Agile Project Management

This paper examines the application of the Experiential Learning Survey (ELS) to a setting involving students’ use of a computer based agile project management simulation. A total of 242 students completed the simulation either individually or as part of a group and reported their experiential learning perceptions regarding the authenticity, active learning, relevance, and utility of the simulation. Results indicate that students completing the simulation as part of a group perceive higher levels of authenticity, active learning, and relevance than students completing the simulation individually.
Critical (panic) value notification: an established laboratory practice policy (parameter)

A laboratory test begins when a clinician (or patient) asks a question that requires a laboratory result to answer. It ends with an appropriate action being taken on the patient's behalf based on that result. There are at least 11 steps in the performance of that test (Figure). We have called that sequence the "brain-to-brain loop. " 1 A chain is known to be only as strong as its weakest link. Thus, anything that interferes with the complete closing of this loop for every laboratory test requested produces at the least, a waste, and at the most, a tragedy. Historically, most laboratory personnel have concentrated on the analytic portion of the loop. However, modern quality assurance requires that laboratory personnel consider all steps, actively participating in preanalytic and postanalytic components. The critical value reporting system is an early example of this expanded approach. Nearly 20 years ago we organized such a
Spectrum Handoff Schemes and Optimum Utilization of Spectrum Holes in Cognitive Radio Network

Cognitive Radio (CR) was proposed as a brain empowered wireless communication system. It uses the software defined radio (SDR) to use and dynamically share the spectrum in an opportunistic manner. In this paper, we have defined a priority assignment technique (CR+) so that spectrum can be used effectively and dynamically and there would be much heavily reduction in the forced termination of a handoff request.
Unicompartmental Arthritis of the Knee

• Unicompartmental arthritis of the knee is a degenerative condition characterized by abnormal articular cartilage in the medial or lateral part of the tibiofemoral joint, which may be associated with meniscal disruption, ligamentous instability, and limb malalignment. • Nonoperative treatments for unicompartmental degenerative arthritis of the knee include oral and injectable medications, weight loss, exercise, physical therapy, canes, crutches, braces, and orthoses. • Arthroscopy for unicompartmental arthritis of the knee can provide a clinical benefit in terms of reduced pain and improved function for patients with mechanical symptoms, mild degenerative disease, and minimal or no malalignment. Meniscal tears, loose bodies, osteophytic spurs, or chondral flaps can cause mechanical symptoms, which can be treated successfully with arthroscopy. • Proximal tibial valgus osteotomy and distal femoral varus osteotomy for treatment of unicompartmental arthritis of the knee can realign a deformed limb, reduce pain, and improve function for active, high-demand patients with a projected life expectancy of twenty years or more. • As a patient's life expectancy and expectations for activity decrease as a result of age and disease, unicompartmental and total knee arthroplasty provide predictably successful surgical options for the treatment of unicompartmental arthritis of the knee. Arthritis of the knee is a common clinical problem: 2% of the United States population older than seventeen years of age and 10% of Americans over sixty-five years of age have clinically relevant arthritis of the knee 1. Arthritis of the knee causes pain and restricts activity, and patients with arthritis are twice as likely to seek medical care as are their peers without arthritis 2. Unicompartmental arthritis of the knee is defined as a condition characterized by degenerative articular cartilage in the medial or lateral aspect of the tibiofemoral joint, which may be associated with meniscal disruption, ligamentous instability, and malalignment 1 …
When the Medium Illustrates the Content: Exploiting the Unique Features of Online Communication.

A decade's worth of online education literature reveals a great deal of consensus on the pedagogical practices necessary to make online courses at least as effective as the face-toface courses they are replacing. As many authors have pointed out, the principles that govern effective online teaching are similar to those that underlie effective classroom-based teaching. Building from Chickering and Gamson's “Seven Principles of Good Practice in Undergraduate Education” (1987), Chickering and Ehrmann (1996) and Graham et al. (2001) illustrate how these same principles apply to online education, in spite of the fact that online teachers and students rarely meet in person. All three articles argue that effective undergraduate education:
Educating primary care physicians in the management of Alzheimer's disease: using practice guidelines to set quality benchmarks

ABSTRACT This paper presents a strategy for training primary care physicians in the identification, diagnosis and management of Alzheimer's disease and related disorders. The strategy uses evidence-based practice guidelines to establish quality benchmarks and then provides training and other interventions to improve the quality of care received by these patients. The three projects described in this paper assumed that training of primary care physicians alone would not be sufficient to achieve the quality benchmarks derived from guidelines. The projects used creative training strategies supplemented by provider “tool kits”, provider checklists, educational detailing, and endorsement from organizational leadership to reinforce what the primary care providers learned in educational sessions. Each project also implemented a system of dementia care management to “wrap around” traditional primary care to ensure that quality benchmarks would be achieved. Outcomes of two completed studies support the premise that it is possible to improve quality of dementia care through physician education that occurs in association with a coordinated system of dementia care management and in collaboration with community agencies to access guideline-recommended social services.
Performance Analysis of Synchronized Iterative Algorithms on Multiprocessor Systems

A statistical model of parallel processing and a performance evaluation technique are introduced. A task is characterized by the number of atoms and by activity. An atom is the smallest part of computation that cannot be distributed to multiple processors and all atoms of a task are assumed to be equal in computational effort. Furthermore, atoms of the task became active with a fixed probability a called the activity. The task is equally divided among processors and the computation is synchronized at periodic instances when the results can be shared. The amount of computational activity of a processor within the period between synchronizations is assumed to be a binomial random variable. The performance of the multiprocessor system is derived from the maximum order-statistic of these random variables. The theoretical performance predicted by the analysis agrees well with the reported experimental performance of logic simulation of production VLSI chips, and several observed phenomena are explainable. >
Distinct mechanisms control the timing of differentiation of two myeloid populations in Xenopus ventral blood islands

Previous study has suggested that distinct populations of myeloid cells exist in the anterior ventral blood islands (aVBI) and posterior ventral blood islands (pVBI) in Xenopus neurula embryo. However, details for differentiation programs of these two populations have not been elucidated. In the present study, we examined the role of Wnt, vascular endothelial growth factor (VEGF) and fibroblast growth factor signals in the regulation of myeloid cell differentiation in the dorsal marginal zone and ventral marginal zone explants that are the sources of myeloid cells in the aVBI and pVBI. We found that regulation of Wnt activity is essential for the differentiation of myeloid cells in the aVBI but is not required for the differentiation of myeloid cells in the pVBI. Endogenous activity of the VEGF signal is necessary for differentiation of myeloid cells in the pVBI but is not involved in the differentiation of myeloid cells in the aVBI. Overall results reveal that distinct mechanisms are involved in the myeloid, erythroid and endothelial cell differentiation in the aVBI and pVBI.
Comparison between the improved sequence network model of wind turbines and the classical model based on sequence networks for short-circuit studies

Space vector theory is a widely used tool to model synchronous and asynchronous machines. In this paper the induction machine dynamic equations were written in terms of space vectors, employing the stationary reference frame. Also, a general short-circuit current expression was derived and decomposed into positive and negative sequence components. In order to validate and compare the model developed with a simplified model found in literature, short-circuit simulations with balanced and unbalanced sources were performed. The results shown that, for some cases, the mismatches between those approaches are relevant and cause some problems during design, coordination of protection and control stages of machine systems. Discrete Fourier Transform (DFT) and mean squared error (MSE) were used to accomplish this comparison. Finally, a different approach for modeling sequence voltages was proposed and compared with the two methodologies aforementioned.
Mechanism-Based Inactivation of Cytochrome P450 3A4 by Lapatinib

Fatalities stemming from hepatotoxicity associated with the clinical use of lapatinib (Tykerb), an oral dual tyrosine kinase inhibitor (ErbB-1 and ErbB-2) used in the treatment of metastatic breast cancer, have been reported. We investigated the inhibition of CYP3A4 by lapatinib as a possible cause of its idiosyncratic toxicity. Inhibition of CYP3A4 was time-, concentration-, and NADPH-dependent, with kinact = 0.0202 min−1 and Ki = 1.709 μM. The partition ratio was approximately 50.9. Addition of GSH did not affect the rate of inactivation. Testosterone protected CYP3A4 from inactivation by lapatinib. The characteristic Soret peak associated with a metabolite-intermediate complex was not observed for lapatinib during spectral difference scanning. However, reduced carbon monoxide (CO)-difference spectroscopy did reveal a 43% loss of the spectrally detectable CYP3A4-CO complex in the presence of lapatinib. Incubation of either lapatinib or its dealkylated metabolite with human liver microsomes in the presence of GSH resulted in the formation of a reactive metabolite (RM)-GSH adduct derived from the O-dealkylated metabolite of lapatinib. In addition, coincubation of lapatinib with ketoconazole inhibited the formation of the RM-GSH adduct. In conclusion, we demonstrated for the first time that lapatinib is a mechanism-based inactivator of CYP3A4, most likely via the formation and further oxidation of its O-dealkylated metabolite to a quinoneimine that covalently modifies the CYP3A4 apoprotein and/or heme moiety.
The Saudi Initiative for Asthma - 2016 update: Guidelines for the diagnosis and management of asthma in adults and children

This is an updated guideline for the diagnosis and management of asthma, developed by the Saudi Initiative for Asthma (SINA) group, a subsidiary of the Saudi Thoracic Society. The main objective of SINA is to have guidelines that are up to date, simple to understand and easy to use by nonasthma specialists, including primary care and general practice physicians. SINA approach is mainly based on symptom control and assessment of risk as it is the ultimate goal of treatment. The new SINA guidelines include updates of acute and chronic asthma management, with more emphasis on the use of asthma control in the management of asthma in adults and children, inclusion of a new medication appendix, and keeping consistency on the management at different age groups. The section on asthma in children is rewritten and expanded where the approach is stratified based on the age. The guidelines are constructed based on the available evidence, local literature, and the current situation in Saudi Arabia. There is also an emphasis on patient–doctor partnership in the management that also includes a self-management plan.
Association of maspin expression with the high histological grade and lymphocyte‐rich stroma in early‐stage breast cancer

Aims: Maspin is a recently described member of the serpin family or protease inhibitors that is known to be a tumour suppressor gene product. Loss of maspin expression has been found in most breast cancer cases and is correlated with cell motility and tumour invasiveness. However, its precise role in human breast cancer remains to be discovered. We aimed to evaluate the role of maspin in early‐stage breast cancer.
Analytical assessment of wind power generation asset in restructured electricity industry

An analytic approach using real option theory is proposed in this paper for evaluation of wind power generation asset investment in restructured electricity industry. The model for the mean reversion process with long-term periodic mean is employed to describe the special characteristics of electricity price such as fluctuation, uncertainty and periodicity. Analytic expressions for wind power generation output are derived. Based on the established price model and output model, the wind power generation asset to be invested is evaluated by adopting the approach of spark spread real option. Financial tools, such as Value at Risk (VaR) and Conditional Value at Risk (CVaR), are applied for risk assessment. The validity of the proposed method is illustrated by numerical simulation tests.
The Relative Importance of Teenagers' Personal Characteristics on Technology Addiction

As the Internet becomes the major means to conduct business, new types of agenda arise in e-Business arena. One of them is Ethics. Compared to other topics, ethics education for e-services takes long time because of its characteristics. Thus, Cyberethics education is required from childhood. In this paper, we examine the status of the Korean teenagers’ technology addiction, their personal characteristics, and their environmental factors composed of parents, friends, and media to diagnose their behavior and to boost their morality. In order to achieve our research goals, we survey 1,421 primary and secondary school students, and then do factor, regression, and dominance analyses. Also, we examine the relationships between the students’ characteristics and their technology addiction. We focus on the Internet and mobile phone addiction as technology addiction. Based on this study, we summarize a few issues to be solved for our adolescents to do their right actions on e-environment.
Effects of Dietary Vitamins C and E on Egg Shell Quality of Broiler Breeder Hens Exposed to Heat Stress

A feeding trial was conducted to determine whether dietary vitamin C (200 mg/kg) and vitamin E (250 mg/kg) prevent any drops in egg shell quality under heat stress in broiler breeder hens. One hundred and sixty molted Ross broiler breeders were housed randomly in an individual cage at 83 weeks of age. Four dietary treatments with forty hens and four replications per treatment were control (no additional vitamins), vitamin C-, or vitamin E-supplemented and combined supplementation of the two vitamins. After a ten- day-adaptation period at 25°C, the ambient temperature was kept at 32°C for a three-week-testing period. Egg production dropped dramatically over week but it did not show a significant change among treatments (p<0.05). However, egg quality parameters such as egg weight, specific gravity, shell thickness, SWUSA, puncture force and shell breaking strength from the birds fed the diet with the combined vitamins C and E were significantly improved over those of the control group during the heat stress period (p<0.05). The hens fed the vitamin C diet improved tibia breaking strength (37.16 kg), statistically higher than the birds fed the control and the vitamin E diets (p<0.05). The hens fed the control diet showed higher serum corticosterone levels, a mean of 5.97 ng/ml, than those of the other treatments (p<0.05). The heat stress resulted in elevated heterophils and decreased lymphocytes in serum, increasing the H/L ratios for all the treatments. However, the increases in H/L ratios were alleviated by feeding the diets containing vitamin C alone or together with vitamin E, although there were no significant differences in the ratio between the two groups (p<0.05). In conclusion, vitamins C (200 mg/kg) and/or E (250 mg/kg) supplemented to the diets for broiler breeder hens could prevent drops in egg shell quality and tibia bone strength under highly stressful environmental temperatures. (Asian-Aust. J. Anim. Sci. 2005. Vol 18, No. 4 : 545-551)
Fitting Emax models to clinical trial dose–response data when the high dose asymptote is ill defined

We consider fitting the so‐called Emax model to continuous response data from clinical trials designed to investigate the dose–response relationship for an experimental compound. When there is insufficient information in the data to estimate all of the parameters because of the high dose asymptote being ill defined, maximum likelihood estimation fails to converge. We explore the use of either bootstrap resampling or the profile likelihood to make inferences about effects and doses required to give a particular effect, using limits on the parameter values to obtain the value of the maximum likelihood when the high dose asymptote is ill defined. The results obtained show these approaches to be comparable with or better than some others that have been used when maximum likelihood estimation fails to converge and that the profile likelihood method outperforms the method of bootstrap resampling used. Copyright © 2014 John Wiley & Sons, Ltd.
A multicentre single-blind randomized controlled trial comparing bipolar and monopolar transurethral resection of the prostate.

INTRODUCTION Monopolar transurethral resection of the prostate (TURP) is the gold standard surgical therapy for men with lower urinary tract symptoms due to benign prostatic hyperplasia. Although generally considered safer, TURP experience is limited in Canada. METHODS Forty-three patients from 5 Canadian centres were randomized to TURP with either bipolar or monopolar platforms. Patients underwent baseline determinations of American Urological Association (AUA) symptom score, peak urinary flow rate, post-void residual bladder volume and transrectal ultrasound prostate volume. Primary outcome measures were improvement in AUA symptom score, quality of life assessment and bother assessment. Secondary outcomes included procedural times, duration of catheterization, length of hospitalization, complications and the degree of thermal artifact in tissue specimens. Patients were followed for 6 months. RESULTS Twenty-two patients were treated with bipolar and 21 with monopolar TURP. Preoperative demographics were not statistically different between groups. Postoperative data collection times were equivalent in AUA symptom, quality of life, bother and sexual function assessments. No differences were observed in the procedure time (60.7 min, bipolar vs. 47.4, monopolar) or the duration of urethral catheterization (1.5 days, bipolar vs. 1.1, monopolar). More patients in the bipolar group were discharged on the same day of surgery. There were no differences in the degree of tissue thermal artifact or complication rate. CONCLUSION This trial suggests equivalent short-term outcomes for men undergoing monopolar or bipolar TURP.
Expression of TEL-AML1 Fusion Transcripts and Response to Induction Therapy in Standard Risk Acute Lymphoblastic Leukemia

We prospectively examined the frequency of the t(12;21)TEL-AML1 fusion in 504 children with newly diagnosed standard risk ALL using RT-PCR assays. Cells from 95 patients (18.8%) were TEL-AML1+. There was a significantly higher frequency of pseudodiploidy among the TEL-AML1+ cases (39.4% versus 14.1%, P=0.001), primarily because structural abnormalities involving 12p and del(6q) occurred more frequently in the TEL-AML1+ group. TEL-AML1+ ALL was more sensitive to the induction chemotherapy than TEL-AML1- ALL. The percentage of “rapid early responders”, i.e., patients who achieved an M1 (< 5% blasts) or M2 (5–25% blasts) marrow status on day 7 of induction chemotherapy, was significantly higher among TEL-AML1+ cases. The quality of remission of RT-PCR positive cases was excellent, as evidenced by the very low to absent MRD burden of their end-of-induction bone marrow specimens. TEL-AML1+ patients also had an excellent early EFS outcome. The probability of EFS at 30 months from study entry were 98.9×1.0% for the TEL-AML1+ group and 92.1×1.5% for the TEL-AML1- group (P=0.0001). This prospective study significantly expands the knowledge gained from previous studies regarding the prognostic significance of t(12;21)TEL-AML1 fusion in pediatric ALL.