Miracle-dz/UniFAR-FTUs huggingface dataset:
Low-Complexity Hybrid Analog and Digital Precoding for mmWave MIMO Systems

In millimeter-wave (mmWave) massive MIMO systems, to decrease hardware cost and energy consumption, hybrid analog and digital precoding is preferred to pure digital precoding. In this paper, a hybrid precoding method for sub-connected mmWave MIMO systems is developed. To start with, we propose to formulate the hybrid precoding matrix as a Kronecker product of an analog precoding matrix and a digital precoding vector, by enforcing phase shifters connecting to each radio-frequency chain to share the same set of coefficients. Then, the optimal design of the digital and analog precoding matrices is formulated as the nearest Kronecker product (NKP) problem, which is analytically tractable. Finally, a low-complexity algorithm is developed to implement the proposed hybrid precoding method. Simulation results corroborate that the NKP-based hybrid precoding is near-optimal and achieves higher data rates than the successive interference cancellation method. Moreover, the energy efficiency of the proposed design is much higher than the fully-connected architecture.
Dual-Band Single-Layered Modified E-shaped Patch Antenna for RF Energy Harvesting Systems

Radio Frequency Energy Harvesting (RF EH) is an alternative, yet well-promising technique to deliver power in electronic circuits of wireless sensor networks that require small amounts of energy. The design of the receiving module (antenna) in RF EH systems is a demanding and, in most cases, a complex task. As a result, an optimization method is often required. In this paper, we apply The Salp Swarm Algorithm to design and optimize a receiving module (dual-band modified E-shaped antenna) for RF EH systems. The proposed antenna operates in the frequency bands of LTE-2600 and 5G NR mobile communication networks. Numerical results exhibit a satisfactory operation of the optimized antenna as a receiving module in an RF EH system.
Production and characterisation of putative early effector proteins in Chlamydia trachomatis infection

Chlamydia trachomatis is commonly known as the most common bacterial sexually transmitted infection in the world, having affected approximately 3.1% of the global population in 2010, and being a major cause of infertility in men and women. However, what is less well known among the general population is that C. trachomatis also causes the blindness disease trachoma, the leading cause of preventable blindness globally. This project aimed to produce and investigate three proteins known to be involved in the early stages of the infection process: CT694, CT166 and PmpD. CT694 and CT166 are believed to affect actin fibre formation and breakdown, acting in concert with one another to facilitate engulfment of the bacterium by the host. PmpD is a protein which draws significant interest as a vaccination target, as it is present on the outer membrane of C. trachomatis and is conserved very highly among serovars. This project focussed mainly on the breakdown product ΔCT694. Its gene was amplified from Chlamydial genomic DNA and inserted into a plasmid, which was used to transform an expression strain of Escherichia coli. Batches of protein were produced for characterisation and investigation, mainly commercial and customised crystallisation screens. Although no crystals were achieved, a promising microcrystalline precipitate formed, and a “best condition” has been recorded. In addition, the fragment PmpD F2 was produced regularly for vaccine studies by inclusion body preparation, and characterisation experiments were performed upon the protein. Work on PCR and gene cloning of PmpD fragments and CT166 was performed as well. Although the primary goal of producing X-ray diffractable crystals was not met, this project has laid the foundations within the group for development and future work.
A finite element analysis to study the stress distribution on distal implants in an all-on-four situation in atrophic maxilla as affected by the tilt of the implants and varying cantilever lengths

Aim: The aim of this work was to evaluate stress distribution on implants in All-on-Four situation with varying distal implant angulations (30°,40°,45°) and varying cantilever lengths (4 mm, 8 mm, 12 mm, 16 mm) in atrophic maxilla using finite element analysis. Setting and Design: A in vitro study, finite element analysis. Materials and Methodology: Three-dimensional finite element model of an edentulous maxilla restored with a prosthesis supported by four implants was reconstructed to carry out the analysis. Three different configurations, corresponding to 3 tilt degrees of the distal implants (30°, 40°, and 45°) were subjected to 4 loading simulations. Statistical Analysis Used: The results of the simulations obtained were evaluated in terms of Von Mises equivalent stress levels at the bone-implant interface. Result: From a stress-level viewpoint, the 45° model was revealed to be the most critical for peri-implant bone. In all the loading simulations, the maximum stress values were always found at the neck of the distal implants. With increasing distal implant tilt, cantilever length reduces depending on the quality of bone. At 30° angulation of distal implant a maximum cantilever length of 16 mm may be given if the quality of bone is D3 but only 8 mm cantilever may be recommended if bone quality is D4. At 40° angulation, 16 mm in D3 bone and 0 mm in D4 bone whereas at 45° angulation, it reduces to 12 mm in D3 bone and no cantilever is recommended with D4 bone. Conclusion: The 45° tilt induced higher stress values at the bone-implant interface, especially in the distal aspect, than the other 2 tilts analyzed. Stress values increased with increased cantilever length which was further influenced by the distal implant tilt and the quality of the bone.
The Mechanism and Tumorigenesis of Oncogenic DNA Virus Integration

Cancer is one kind of diseases which seriously jeopardized the health of human beings. Oncogenic DNA virus is a leading factor for many kinds of cancer. Virus DNA integration could cause host cell organization inflammation and tumorigenesis. Its integration could induce the host genome instability and rearrangement. It could also cause the alterations of host transcriptome such as viral promoter driven human transcription, viral-human transcription fusion and form new fusion gene,and the host gene expression change. Meanwhile, it's one of the mechanisms for virus replication, escape the host immunological recognition and maintain itself. The review focus on the research and the progress of the oncogenic DNA virus integration regulation and the carcinogenic effect of its integration. We also prospect the oncogenic DNA virus integration research direction and the application on the cancer occurrence, development, diagnose and therapy.
The mitochondrial genome of Coridius chinensis (Hemiptera: Dinidoridae)

The nearly complete mitochondrial genome of Coridius chinensis (Dallas) is reported in this study. The mitogenome is a double-stranded circular molecule of more than 14,648 bp in length with an A+T content of 75.1%. It encoded 37 genes as in other insect mtDNAs, including 13 protein-coding genes (PCGs), 22 tRNA genes, 2 rRNA genes and a control region (unsuccessful sequencing), and the gene order is the same as most other known heteropteran mitogenomes. All of the 22 transfer RNAs can be folded into the typical cloverleaf structure except tRNA, which can only form a simple loop at the site of dihydrouridine (DHU) arm as known in other metazoans. The secondary structures of the large and small ribosomal RNAs of C. chinensis are similar to other presented insects. The rrnL consisted of six structural domains and 40 helices, and the rrnS consisted of three structural domains and 26 helices. Nine PCGs are initiated with the standard initiation codons (ATN), while ND6 and ND1 use GTG, and COI and ATP8 use TTG. All PCGs stopped with TAA/TAG termination codons except the COII terminated with a single T residue. Asymmetry in the nucleotide composition between J-strand and N-strand was observed in this mitogenome.
The Potency of Bioactive Compounds of Coffee as Antidiabetic

Recently, the popularity of coffee is gaining popularity. The researcher found that the benefit of coffee was not refreshing only but also improved the quality of health. These effectsexistdue to the natural bioactive compounds found in the coffee. The bioactive compounds of coffee have activity as an antioxidant, anti-inflammation, anti-microbe, and recently as antidiabetic. The major compounds found in coffee were chlorogenic acid, trigonelline, diterpene, and Maillard reaction product (exp.melanoidin). The objective of this study was to explore the bioactive compounds of coffee and the potency antidiabetic, conducted by in-vitro, in-vivo, clinically, and epidemiology intergrately. The in-vitro analysis shown thatcoffee had activity asan inhibitor -glucosidase, the compounds were chlorogenic acids. In the in-vivo study,coffee brewwas able to reduce blood glucose
Helping Couples Connect during the COVID‐19 Pandemic: A Pilot Randomised Controlled Trial of an Awareness, Courage, and Love Intervention

Background A second pandemic of mental health problems due to COVID‐19 is predicted, suggesting a demand for interventions to mitigate its impacts. This study evaluated the effectiveness of an online psychological intervention based on the Awareness, Courage, and Love (ACL) model from Functional Analytic Psychotherapy to promote closeness between couples during the pandemic. Method Thirty‐one couples were randomised into either the intervention or control group for a 2‐hour online group session. The intervention was designed to increase closeness between couples, whereas control group members watched a movie. In both groups, participants responded to two instruments that assessed the couple's relationship. Generalised linear mixed modeling was used to compare the change scores over time between the groups, with random effects used to control for the correlation within a couple and the correlation within the individual. Results The intervention group’s closeness increased by 23 per cent while the control group’s closeness increased only 2 per cent. A week later, a significant difference between the two groups emerged on closeness. Conclusion Online ACL protocols requiring minimal training offer a promising intervention to quickly buffer against stress for large numbers of individuals during pandemic times.
The Arabidopsis bHLH transcription factor DYT1 is essential for anther development by regulating callose dissolution

Callose formation and dissolution during and after meiotic division is a unique feature of male meiosis and is important for pollen development in plants.Here,we report the identification and characterization of a male-sterile mutant,ms157,which exhibits irregular tapetum differentiation and callose dissolution during anther development in Arabidopsis.Molecular mapping and genetic analysis indicated that MS157 is an allele of bHLH transcription factor DYT1(At4g21330). Thus,the mutant was renamed as dyt1-2.Our trans-activation activity assay showed the activation domain of DYT1 is located in 250bp to 504bp.Yeast two hybrid assay also suggested that two DYT1 entire proteins could form homodimers in vivo.RT-PCR and Real-Time PCR analysis indicated that callase complex related gene A6 was down-regulated in the mutant background.Hence,DYT1 plays an important role in anther development by regulating callose dissolution.
The mRNA derived MalH sRNA contributes to alternative carbon source utilization by tuning maltoporin expression in E. coli

ABSTRACT Previous high-throughput studies in Gram-negative bacteria identified a large number of 3ʹUTR fragments that potentially function as sRNAs. Here we extensively characterize the MalH sRNA. We show that MalH is a stable degradation intermediate derived from the 3ʹ end of malG, which is part of the maltose uptake operon transcript malEFG. Unlike the majority of bacterial sRNAs, MalH is transiently expressed during the transition from the exponential to the stationary growth phase, suggesting that it contributes to adaptation to changes in nutrient availability. Over-expression of MalH reduces expression of general outer membrane porins and MicA, a repressor of the high-affinity maltose/maltodextrin transporter LamB. Disrupting MalH production and function significantly reduces lamB accumulation when maltose is the only available carbon source, presumably due to the accumulation of the MicA repressor. We propose that MalH is part of a regulatory network that, during the transition phase, directly or indirectly promotes accumulation of high-affinity maltose transporters in the outer membrane by dampening competing pathways.
Validity and reliability of the Iranian version of the Yale Food Addiction Scale for obese women

Abstract Objective: The face and construct validity of the Iranian version of the Yale Food Addiction Scale (YFAS) was evaluated, and the convergent validity and test–retest reliability of both Iranian and original versions of YFAS for obese women were assessed. Design: The internal consistency of the YFAS was analysed. Exploratory factor analysis for dichotomous data was performed by varimax rotation, polychoric correlation coefficients and confirmatory factor analysis (CFA). Convergent validity was established by evaluating the correlation between the original and the Iranian versions of YFAS and the Binge Eating Scale (BES). The intraclass correlation coefficient (ICC) was measured between test–retest results. Setting: A weight management clinic in Tehran. Participants: 450 obese women. Results: The single-factor structure indicated that the factor loadings for all the items were > 0·5, except for three items (explained proportion variance = 51 %). Based on CFA, the single factor had a better fit to the data after excluding three items. The Kuder–Richardson-20 coefficient was 0·86 for the total twenty-two items. The symptom count and diagnostic version of both the Iranian (ICC = 0·92 and 0·87, respectively) and original YFAS (ICC = 0·92 and 0·86, respectively) were stable over 2 weeks. Both the symptom count and the diagnostic version of these two scales had significant correlations with the measures of BES (P < 0·001). Conclusions: The initial reliability and validity of the Iranian version of the YFAS among obese women are supported. Further studies should be conducted on men and normal/overweight samples.
Material decomposition for simulated dual-energy breast computed tomography via hybrid optimization method.

BACKGROUND Dual-energy breast CT reconstruction has a potential application that includes separation of microcalcification from healthy breast tissue for assisting early breast cancer detection. OBJECTIVE To investigate and validate the noise suppression algorithm applied in the decomposition of the simulated breast phantom into microcalcification and healthy breast. METHODS The proposed hybrid optimization method (HOM) uses a simultaneous algebraic reconstruction technique (SART) output as a prior image, which is then incorporated into the self-adaptive dictionary learning. This self-adaptive dictionary learning seeks each group of patches to faithfully represent the learned dictionary, and the sparsity and non-local similarity of group patches are used to enforce the image regularization term of the prior image. We simulate a numerical phantom by adding different levels of Gaussian noise to test performance of the proposed method. RESULTS The mean value of peak signal-to-noise ratio (PSNR), structural similarity (SSIM), and root mean square error (RMSE) for the proposed method are (49.043±1.571), (0.997±0.002), (0.003±0.001) and (51.329±1.998), (0.998±0.002), (0.003±0.001) for 35 kVp and 49 kVp, respectively. The PSNR of the proposed method shows greater improvement over TWIST (5.2%), SART (34.6%), FBP (40.4%) and TWIST (3.7%), SART (39.9%), FBP (50.3%) for 35 kVp and 49 kVp energy images, respectively. For the proposed method, the signal-to-noise ratio (SNR) of decomposed normal breast tissue (NBT) is (22.036±1.535), which exceeded that of TWIST, SART, and FBP by 7.5%, 49.6%, and 96.4%, respectively. The results reveal that the proposed algorithm achieves the best performance in both reconstructed and decomposed images under different levels of noise and the performance is due to the high sparsity and good denoising ability of minimization exploited to solve the convex optimization problem. CONCLUSIONS This study demonstrates the potential of applying dual-energy reconstruction in breast CT to detect and separate clustered MCs from healthy breast tissues without noise amplification. Compared to other competing methods, the proposed algorithm achieves the best noise suppression performance for both reconstructed and decomposed images.
Proliferation Culture of Embryonic Callus of Chenshan Red-heart Chinese Fir

The effects of different hormones on the embryogenic callus growth of Chenshan red-heart chinese fir were studied,the results showed that proliferation effects of NAA on callus were very different at the stage of induction and proliferation culture of embryogenic callus of Chenshan red-heart chinese fir.The effect of 2,4-D was much better than that of NAA in the induction stage,while NAA also showed good effect in the proliferation stage,6-BA has apparent inhibition for the growth of embryogenic callus.
Multiple rapid swallows and rapid drink challenge in patients with esophagogastric junction outflow obstruction on high‐resolution manometry

Esophagogastric junction outflow obstruction (EGJOO) as defined by Chicago Classification of esophageal motility disorders (CCv3.0) encompasses a broad range of diagnoses, thus posing clinical challenges. Our aims were to evaluate multiple rapid swallow (MRS) and rapid drink challenge (RDC) during high‐resolution manometry (HRM) to aid identifying clinically relevant EGJOO.
PANK2 p.A170fs：a novel pathogenetic mutation, compound with PANK2 p.R440P, causing pantothenate kinase Associated neurodegeneration in a Chinese family

Abstract Aim Pantothenate kinase associated neurodegeneration (PKAN) is a severe autosomal recessive rare disease and characterized by iron accumulation in the basal ganglia. To investigate the pathogenesis of this disease in two sibling patients with PANK in a Chinese family, whole-exome variant detection and functional analysis were performed. Materials and methods Clinical and radiographic investigations were performed in the two brother patients. Whole exome sequencing (WES) was used in mutation detection, and the mutations were confirmed by Sanger sequencing. A longevity cohort genetic database was applied as Chinese urban controls. Bioinformatic analysis was performed to predict the pathogenicity. Results Compound heterozygous mutations of PANK2 were detected in two sibling brothers with PKAN in a Chinese family: c. 510_522del (p.A170fs) and c.1319G > C (p.R440P) in the transcript NM_153638. PANK2: c. 510_522del (p.A170fs) was absent in public data and the Chinese urban controls. Bioinformatics analysis showed that the above two variants were pathogenicity. Conclusions We identified a rare compound heterozygous combination of PANK2 mutations found in a Chinese family in which two sibling brothers suffered from PKAN. PANK2 c. 510_522del (p.A170fs) was the first reported to be a PKAN pathogenic variant.
Suicide in Spanish Farmers in Two Geographical Areas with Differing Rates of Pesticide Use

ABSTRACT This study assesses whether farmers’ suicides were associated with the pesticide use in Spain. The cohort study followed 9.5 million men aged 20–64 years who were employed in 2001. The mortality among farmers and non-farmers during the period 2001–2011 was estimated in a geographical area with high pesticide use and in an area with low pesticide use. For three major causes of death (suicide, unintentional accidents, and rest of causes of death), we estimated the age-standardized mortality rates with 95% confidence intervals (CI) between farmers and non-farmers in both areas. Farmers in the high pesticide use area showed a lower mortality rate of suicide and unintentional accidents than farmers in the rest of Spain, with mortality rate ratios of 0.74 (95% CI 0.65–0.85) and 0.57 (95% CI 0.52–0.62), respectively. Our findings on pesticide use and farmers’ suicide are different from those observed in several previous investigations.
Application of bioengineering technology to protection of endangered medicinal plant resources

Along with the progress of Chinese pharmaceutical industry, as well as the development of natural products in the world, the need of medicinal plant resources is increasing, which results in the ruinous destruction of endangered medicinal plants. The field cultivation and wild tending cultivation could not solve all the resource problems and the help with bioengineering technolgy will be needed in this field. Micropropagation could quickly supply the shoots with good quality medicinal plants by two ways, the shoot and root induction through callus or the other is shoot development by somatic embryos. The regenerated shoots could be transferred into the field for the base of field cultivation or tending cultivation. In addition, the active compounds could be produced by the cultivated medicinal plant cells, tissues, or organs in bioreactor, which could decrease the cost at industrial level. In China, the bioengineering technology should be developed and applied to the medicinal plants development, because the most resources to support the whole traditiolal Chinese medicine will be utilized, moreover, in China the most amount of extracts from medicinal plants are used and exported all over the world.
Relationships between novel nucleotide variants within the colony-stimulating factor 1 receptor (CSF1R) gene and mastitis indicators in sheep

Abstract Colony-stimulating factor 1 receptor (CSF1R) plays an important role in the process of innate immunity and inflammation, thus it was hypothesized that the CSF1R gene might affect the occurrence of mammalian mastitis. The purpose of this study was to investigate the association between nucleotide variations of CSF1R gene and mastitis in Australian white sheep (AUWs). Two indel variants (Intron5-27 bp and Intron5-22 bp) within the CSF1R gene have been found in AUWs. The Chi-square test for different mastitis symptoms demonstrated that individuals without symptoms of mastitis had higher ‘I’ allele frequencies and ‘II’ genotype frequencies (p < 0.01). We found strong correlation between mastitis and lactation score through Pearson correlation analysis. Therefore, we also analyzed the relationship between the two indel loci and lactation, we found that the lactation ability of individuals with type II was stronger than that of DD genotype at the Intron5-22 bp (p < 0.05). Additionally, we found that the combined genotype of the two loci was significantly associated with mastitis (p < 0.01). These findings indicated that CSF1R mutations were significantly associated with mastitis, and could affect lactation performance, suggesting that two deletion sites could be used as the effective molecular markers against mastitis in sheep breeding.