Miracle-dz/UniFAR-FTUs huggingface dataset:
Chapter 18 CONSTRAINT-BASED DATA MINING

Knowledge Discovery in Databases (KDD) is a complex interactive process. The promising theoretical framework of inductive databases considers this is essen- tially a querying process. It is enabled by a query language which can deal either with raw data or patterns which hold in the data. Mining patterns turns to be the so-called inductive query evaluation process for which constraint-based Data Mining techniques have to be designed. An inductive query specifies declara- tively the desired constraints and algorithms are used to compute the patterns satisfying the constraints in the data. We survey important results of this active research domain. This chapter emphasizes a real breakthrough for hard prob- lems concerning local pattern mining under various constraints and it points out the current directions of research as well.
Flexible manipulation of Omb levels in the endogenous expression region of Drosophila wing by combinational overexpression and suppression strategy

Manipulating an exogenous or endogenous gene of interest at a defined level is critical for a wide variety of experiments. The Gal4/UAS system has been widely used to direct gene expression for studying complex genetic and biological problems in Drosophila melanogaster and other model organisms. Driven by a given tissue‐specific Gal4, expressing UAS‐transgene or UAS‐RNAi (RNA interference) could be used to up‐ or down‐regulate target gene expression, respectively. However, the efficiency of the Gal4/UAS system is roughly predefined by properties of transposon vector constructs and the insertion site in the transgenic stock. Here, we describe a simple way to modulate optomotor blind (omb) expression levels in its endogenous expression region of the wing disc. We co‐expressed UAS‐omb and UAS‐omb‐RNAi together under the control of dpp‐Gal4 driver which is expressed in the omb expression region of the wing pouch. The repression effect is more sensitive to temperature than that of overexpression. At low temperature, overexpression plays a dominant role but the efficiency is attenuated by UAS‐omb‐RNAi. In contrast, at high temperature RNAi predominates in gene expression regulation. By this strategy, we could manipulate omb expression levels at a moderate level. It allows us to manipulate omb expression levels in the same tissue between overexpression and repression at different stages by temperature control.
Impacts of Teaching Test-Driven Development to Novice Programmers

(Abstract) Due to the popularity of Test-Driven Development (TDD) among software professionals, some schools have integrated it into their computing curricula. Through exposure to TDD, students gain practical experience while future employers benefit from their familiarity with the technique. However, it is important to investigate empirically whether the use of TDD in the classroom affects student performance or improves the quality of their code. Our study leverages an extensive data set representing multiple years of teaching TDD in introductory computer science classes.
Antiaging and smoothness‐improving properties of farnesol‐based facial masks on rat skin exposed to ultraviolet B

Farnesol is an acyclic sesquiterpene presents in various natural sources including fruits, vegetables, and herbs. In this study, we successfully prepared a farnesol‐containing gel with ultraviolet B‐screening and skin‐repairing capabilities. Furthermore, the advantageous potential of farnesol‐containing facial masks for UVB‐caused sunburnt skin was evaluated.
Respiratory Illness in a Piggery Associated with the First Identified Outbreak of Swine Influenza in Australia: Assessing the Risk to Human Health and Zoonotic Potential

Australia was previously believed to be free of enzootic swine influenza viruses due strict quarantine practices and use of biosecure breeding facilities. The first proven Australian outbreak of swine influenza occurred in Western Australian in 2012, revealing an unrecognized zoonotic risk, and a potential future pandemic threat. A public health investigation was undertaken to determine whether zoonotic infections had occurred and to reduce the risk of further transmission between humans and swine. A program of monitoring, testing, treatment, and vaccination was commenced, and a serosurvey of workers was also undertaken. No acute infections with the swine influenza viruses were detected. Serosurvey results were difficult to interpret due to previous influenza infections and past and current vaccinations. However, several workers had elevated haemagglutination inhibition (HI) antibody levels to the swine influenza viruses that could not be attributed to vaccination or infection with contemporaneous seasonal influenza A viruses. However, we lacked a suitable control population, so this was inconclusive. The experience was valuable in developing better protocols for managing outbreaks at the human–animal interface. Strict adherence to biosecurity practices, and ongoing monitoring of swine and their human contacts is important to mitigate pandemic risk. Strain specific serological assays would greatly assist in identifying zoonotic transmission.
Physical activity trajectories and mortality: population based cohort study

Abstract Objective To assess the prospective associations of baseline and long term trajectories of physical activity on mortality from all causes, cardiovascular disease, and cancer. Design Population based cohort study. Setting Adults from the general population in the UK. Participants 14 599 men and women (aged 40 to 79) from the European Prospective Investigation into Cancer and Nutrition-Norfolk cohort, assessed at baseline (1993 to 1997) up to 2004 for lifestyle and other risk factors; then followed to 2016 for mortality (median of 12.5 years of follow-up, after the last exposure assessment). Main exposure Physical activity energy expenditure (PAEE) derived from questionnaires, calibrated against combined movement and heart rate monitoring. Main outcome measures Mortality from all causes, cardiovascular disease, and cancer. Multivariable proportional hazards regression models were adjusted for age, sex, sociodemographics, and changes in medical history, overall diet quality, body mass index, blood pressure, triglycerides, and cholesterol levels. Results During 171 277 person years of follow-up, 3148 deaths occurred. Long term increases in PAEE were inversely associated with mortality, independent of baseline PAEE. For each 1 kJ/kg/day per year increase in PAEE (equivalent to a trajectory of being inactive at baseline and gradually, over five years, meeting the World Health Organization minimum physical activity guidelines of 150 minutes/week of moderate-intensity physical activity), hazard ratios were: 0.76 (95% confidence interval 0.71 to 0.82) for all cause mortality, 0.71 (0.62 to 0.82) for cardiovascular disease mortality, and 0.89 (0.79 to 0.99) for cancer mortality, adjusted for baseline PAEE, and established risk factors. Similar results were observed when analyses were stratified by medical history of cardiovascular disease and cancer. Joint analyses with baseline and trajectories of physical activity show that, compared with consistently inactive individuals, those with increasing physical activity trajectories over time experienced lower risks of mortality from all causes, with hazard ratios of 0.76 (0.65 to 0.88), 0.62 (0.53 to 0.72), and 0.58 (0.43 to 0.78) at low, medium, and high baseline physical activity, respectively. At the population level, meeting and maintaining at least the minimum physical activity recommendations would potentially prevent 46% of deaths associated with physical inactivity. Conclusions Middle aged and older adults, including those with cardiovascular disease and cancer, can gain substantial longevity benefits by becoming more physically active, irrespective of past physical activity levels and established risk factors. Considerable population health impacts can be attained with consistent engagement in physical activity during mid to late life.
Metabolic Profiling of Water-Soluble Compounds from the Extracts of Dark Septate Endophytic Fungi (DSE) Isolated from Scots Pine (Pinus sylvestris L.) Seedlings Using UPLC–Orbitrap–MS

Endophytes are microorganisms living inside plant hosts and are known to be beneficial for the host plant vitality. In this study, we isolated three endophytic fungus species from the roots of Scots pine seedlings growing on Finnish drained peatland setting. The isolated fungi belonged to dark septate endophytes (DSE). The metabolic profiles of the hot water extracts of the fungi were investigated using Ultrahigh Performance Liquid Chromatography with Diode Array Detection and Electron Spray Ionization source Mass Spectrometry with Orbitrap analyzer (UPLC–DAD–ESI–MS–Orbitrap). Out of 318 metabolites, we were able to identify 220, of which a majority was amino acids and peptides. Additionally, opine amino acids, amino acid quinones, Amadori compounds, cholines, nucleobases, nucleosides, nucleotides, siderophores, sugars, sugar alcohols and disaccharides were found, as well as other previously reported metabolites from plants or endophytes. Some differences of the metabolic profiles, regarding the amount and identity of the found metabolites, were observed even though the fungi were isolated from the same host. Many of the discovered metabolites have been described possessing biological activities and properties, which may make a favorable contribution to the host plant nutrient availability or abiotic and biotic stress tolerance.
Isolation, semi-synthesis, free-radicals scavenging, and advanced glycation end products formation inhibitory constituents from Parmotrema tinctorum

Abstract Bioassay-guided separation of acetone extract from lichen Parmotrema tinctorum (Delise ex Nyl.) Hale led to the isolation of six major phenolic constituents (1–6). Compounds structures were established using NMR and mass spectral techniques. Further, to develop libraries on these scaffolds, a series of semi-synthetic derivatives were prepared (1a–1f, 2a–2b, 3a, 5a) and investigated for their free-radicals (2,2-diphenyl-1-picrylhydrazyl and 2,2′-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS)) scavenging and advanced glycation end products (AGEs) formation inhibitory activities. Amongst tested derivatives, 1a, 1d, 1e, 2a, and 5a showed strong ABTS scavenging potentials comparable to Trolox. In addition, these derivatives also manifested moderate AGEs formation inhibitory activities.
Retrospective Analysis of Cancer Care Performance and Survival Outcome for Nasopharyngeal Carcinoma at a leading Cancer Treatment Centre in Malaysia 2008-2012

Objective: This report focuses on a private medical centre cancer care performance as measured by patient survival outcome for up to 5 years. Methods: All patients with nasopharyngeal cancer treated at SJMC between 2008 and 2012 were enrolled for this observational cohort study. Mortality outcome was ascertained through record linkage with national death register, linkage with hospital registration system and finally through direct contact by phone. Result: 266 patients treated between 2008 and 2012 were included for survival analysis. 31% of patients were diagnosed with Early NPC Cancer (Stage I or II), another 44% with Locally Advanced Cancer (Stage III) and 25% with late stage IV metastatic cancer. 2%, 27% and 67% had WHO Class I, II and III NPC respectively. The overall survival at 5 years was 100% for patients with Stage I disease, 91% for Stage II disease, 72% for Stage III disease, and decreasing to 44% for Stage IV disease. Overall survival at 5 years for all stages was 73%. Conclusion: SJMC is among the first hospitals in Malaysia to embark on routine measurement of the performance of its cancer care services and its results are comparable to any leading centers in developed countries.
Gerontological social work and cardiac rehabilitation

ABSTRACT Cardiac rehabilitation is a setting in which integrating social work services can benefit older adults. Many cardiac rehabilitation patients endorse symptoms of stress and depression following a cardiac event, impeding their ability to participate fully in cardiac rehabilitation services or recover from a heart attack. Gerontologically trained social workers can improve the care of older adults with heart disease in a variety of ways and this paper discusses the potential roles social workers can play in enhancing care. Two examples demonstrating how community academic partnerships can lead to improved options for older adults following a heart attack are discussed. First, using a microsystems approach, social workers embedded within cardiac rehabilitation may improve patient quality of life, address social service needs, provide mental health treatment, and assist in the completion of standard cardiac rehabilitation assessments. Second, using a macrosystems approach, social workers can help communities by developing partnerships to establish infrastructure for new cardiac rehabilitation clinics that are integrated with mental health services in rural areas. Social workers can serve an important role in addressing the psychological or social service needs of cardiac rehabilitation patients while increasing access to care.
Using Telehealth to Address Pediatric Obesity in Rural Pennsylvania

Abstract Introduction: While for adults in Pennsylvania, obesity rates tripled from less than 10% in 1990 to 30% in 2015, the combined rates of overweight, obese, and severely obese children and adolescents in Pennsylvania are projected to approach 37.11% by the end of 2018. Method: Pediatric obesity rates in rural areas tend to be even higher than those in urban areas. Pediatric obesity needs to be addressed, since it is strongly correlated with several chronic diseases. Given the scarcity of resources to manage this trend, innovative population-based approaches are needed. Web-based telehealth, telemedicine, mobile health (mHealth), and telephone conferences have been proposed as solutions to treat and prevent childhood obesity in rural areas; the most suitable solution is through a family-based telemedicine intervention. The purpose of this study is to explore the feasibility of such a telehealth application especially for rural Pennsylvania. Results: Telehealth use in healthcare organizations in Pennsylvania is scarce; however, 92% of Pennsylvania’s school districts meet the minimum internet connectivity standards. Discussions: This article, while acknowledging barriers to the adoption of the internet-based telemedicine resources, discusses solutions for increasing their availability and dissemination in rural Pennsylvania. Current internet connectivity standards in Pennsylvania schools reflect ability to participate in telehealth programs in terms of technological background, but schools are not engaged in such programs. An appraisal of the real-life challenges to implement this modality is critical and will pave the way for advocacy and implementation of useful telehealth services in low-resource areas.
Checksum Based Centralized Management Framework for Internal Intrusion Detection and Prevention

With the wide usage of internet in many fields, networks are more exposed to attacks such as distributed denial of service (DDoS) attack, IP Spoofing, worm/virus, and so on [2]. Therefore, awareness of net attacks is vital. Intrusion Detection and Prevention Systems (IDPS) are security systems that are used to detect and prevent security threats in the network. IP spoofing is one of the attacks in the network. It is a technique used to gain unauthorized access to computers, whereby the interloper sends messages to a system with associate IP address indicating that the message is returning from a trustworthy host. In proposed system an effective method for defense against IP spoofing is used, which is based on checksum and the cooperation with centralized checksum verification server. The protocol is designed at application layer to detect and prevents the intruder who is spoofing an IP address of another system. The expected result is to demonstrate the method that can effectively and steadily detects and prevents the IP spoofing attack, there by verifying checksum and block. Keywords—Checksum, Router, IP Spoofing
Evaluation of a low-technology system to obtain morphological and mobility trial measurements in dogs and investigation of potential predictors of canine mobility.

OBJECTIVE To develop a low-technology system that can be used by dog owners to obtain morphological and mobility measurements in companion dogs as candidate components of an eventual canine frailty scale. ANIMALS 57 adult (≥ 1-year-old) dogs enrolled by 43 owners. PROCEDURES Morphological measurements of dogs were performed by investigators and dog owners. Dogs participated in timed in-clinic mobility trials across a flat surface (on-leash trial with the owner, on-leash trial with the investigator, and off-leash trial) and on stairs; each trial was repeated 3 times. Owners were asked to conduct a second stair trial at home 2 weeks later. Agreement between owner- and investigator-obtained measurements was assessed with Shrout-Fleiss intraclass correlation coefficients and paired t tests. Age, quartile of projected percentage of mean life span attained (adjusted for body weight), and height were evaluated as predictors of speed and stride length in mobility trials with linear regression and Spearman rank correlation analysis. RESULTS Agreement between owner- and investigator-obtained morphological measurements was strong. Age was a weak but significant predictor of decreased dog speed in mobility trials (adjusted R2, 0.10 to 0.23). Speed decreased significantly with increasing quartile of projected life span attained. A linear regression model that included height and age predicted dog speed better than models with age or height alone. CONCLUSIONS AND CLINICAL RELEVANCE Morphological and mobility trial measurements can be obtained by dog owners with minimal training. Low-technology measurements of mobility trial speed offer potential as components in a future scoring scale for canine frailty.
Development of Physical Computing Curriculum in Elementary Schools for Computational Thinking

Block-based educational programming language(EPL) is commonly used due to its availability at low or no cost. It is also preferred tool of computing education due to its intuitive design, ease-of-use and its effectiveness in increasing algorithmic thinking abilities especially in elementary students. Physical computing is also necessary because it brings students closer to real-world problem solving by connecting the real world with the computing environment. However, due to high-cost and required knowledge in electrical engineering, many schools find the education difficult to access. The study shows significant increase in computational thinking abilities in both groups treated with EPL and additional physical computing education.
Effect of Chitin Whiskers on the Molecular Dynamics of Carrageenan-Based Nanocomposites

Films of carrageenan (KC) and glycerol (g) with different contents of chitin nanowhiskers (CHW) were prepared by a solution casting process. The molecular dynamics of pure carrageenan (KC), carrageenan/glycerol (KCg) and KCg with different quantities of CHWs as a filler was studied using dielectric relaxation spectroscopy. The analysis of the CHW effect on the molecular mobility at the glass transition, Tg, indicates that non-attractive intermolecular interactions between KCg and CHW occur. The fragility index increased upon CHW incorporation, due to a reduction in the polymer chains mobility produced by the CHW confinement of the KCg network. The apparent activation energy associated with the relaxation dynamics of the chains at Tg slightly increased with the CHW content. The filler nature effect, CHW or montmorillonite (MMT), on the dynamic mobility of the composites was analyzed by comparing the dynamic behavior of both carrageenan-based composites (KCg/xCHW, KCg/xMMT).
Modeling of Solid–Liquid Equilibria in Deep Eutectic Solvents: A Parameter Study

Deep eutectic solvents (DESs) are potential alternatives to many conventional solvents in process applications. Knowledge and understanding of solid–liquid equilibria (SLE) are essential to characterize, design, and select a DES for a specific application. The present study highlights the main aspects that should be taken into account to yield better modeling, prediction, and understanding of SLE in DESs. The work is a comprehensive study of the parameters required for thermodynamic modeling of SLE—i.e., the melting properties of pure DES constituents and their activity coefficients in the liquid phase. The study is carried out for a hypothetical binary mixture as well as for selected real DESs. It was found that the deepest eutectic temperature is possible for components with low melting enthalpies and strong negative deviations from ideality in the liquid phase. In fact, changing the melting enthalpy value of a component means a change in the difference between solid and liquid reference state chemical potentials which results in different values of activity coefficients, leading to different interpretations and even misinterpretations of interactions in the liquid phase. Therefore, along with reliable modeling of liquid phase non-ideality in DESs, accurate estimation of the melting properties of their pure constituents is of clear significance in understanding their SLE behavior and for designing new DES systems.
Energy Efficient Open Loop Control of Permanent Magnet Synchronous Motors for Fan Applications

The paper deals with the problem of V/f control of a Permanent Magnet Synchronous Motor without winding dumper for fan applications. Based on stability analysis, an additional stabilizing loop is introduced. Voltage optimization was carried out in order to minimize the input power of PMSM. Simulation results confirmed the validity of the applied solution for fan applications. Keywords— pm motor drive, adjustable speed drive, optimisation
Importance of active layer freeze-thaw cycles on the riverine dissolved carbon export on the Qinghai-Tibet Plateau permafrost region

The Qinghai-Tibet Plateau (QTP) is experiencing severe permafrost degradation, which can affect the hydrological and biogeochemical processes. Yet how the permafrost change affects riverine carbon export remains uncertain. Here, we investigated the seasonal variations of dissolved inorganic and organic carbon (DIC and DOC) during flow seasons in a watershed located in the central QTP permafrost region. The results showed that riverine DIC concentrations (27.81 ± 9.75 mg L−1) were much higher than DOC concentrations (6.57 ± 2.24 mg L−1). DIC and DOC fluxes were 3.95 and 0.94 g C m−2 year−1, respectively. DIC concentrations increased from initial thaw (May) to freeze period (October), while DOC concentrations remained relatively steady. Daily dissolved carbon concentrations were more closely correlated with baseflow than that with total runoff. Spatially, average DIC and DOC concentrations were positively correlated with vegetation coverage but negatively correlated with bare land coverage. DIC concentrations increased with the thawed and frozen depths due to increased soil interflow, more thaw-released carbon, more groundwater contribution, and possibly more carbonate weathering by soil CO2 formed carbonic acid. The DIC and DOC fluxes increased with thawed depth and decreased with frozen layer thickness. The seasonality of riverine dissolved carbon export was highly dependent on active layer thawing and freezing processes, which highlights the importance of changing permafrost for riverine carbon export. Future warming in the QTP permafrost region may alter the quantity and mechanisms of riverine carbon export.