Miracle-dz/UniFAR-FTUs huggingface dataset:
Source Provisioning for Cloud Computing: Challenges, Architecture, and Solutions :Using SLA

Cloud computing systems promise to offer subscription-oriented, enterprise-quality computing services to users worldwide. With the increased demand for delivering services to a large number of users, they need to offer differentiated services to u sers and meet their quality expectations. Existing resource management systems in data centers are yet to support Service Level Agreement (SLA)-oriented resource allocation, and thus need to be enhanced to realize cloud computing and utility computing. In addition, no work has been done to collectively incorporate customer-driven service management, computational risk management, and autonomic resource management into a market-based resource management system to target the rapidly changing enterprise requirements of Cloud computing. This paper presents vision, challenges, and architectural elements of SLA-oriented resource management. The proposed architecture supports integration of market-based provisioning policies and virtualisation technologies for flexible allocation of resources to applications. The performance results obtained from our working prototype system shows the feasibility and effectiveness of SLA-based resource provisioning in Clouds.
DOES CAPITAL STRUCTURE HAVE A MEDIATION EFFECT ON OWNERSHIP STRUCTURE AND FINANCIAL CORPORATE PERFORMANCE? EVIDENCE FROM KENYA

The objective of this paper was to determine the mediating effect of capital structure on the relationship between ownership structure and financial performance of non-financial firms listed on the NSE. The target population was forty-two firms; however, only thirty-five firms had consistency of data for a balanced panel regression for the period 2008-2017. The study adopted longitudinal quantitative research design with random-effects GLS and fixed effects models. The ownership structure was measured using managerial, institutional, government and retail ownerships while capital structure was measured using leverage ratio. In addition, financial performance was proxed by ROCE and Tobin’s Q. The analysis revealed that the capital structure has no significant mediating influence on managerial, government, and retail ownerships and financial performance. However, the study confirmed that there is a significant partial mediating effect of capital structure on the relationship between institutional ownership and quoted firm’s financial performance. The study recommends that the government should introduce initiatives that are aimed at attracting more investors since the current market is dominated by institutional investors. Finally, the study confirms stakeholders, stewardship and pecking order theories and rebuts capital structure irrelevancy and agency theories. JEL: D24, O16, O16 Article visualizations:
Pancreatic Islet Cells Are Involved in Immune Cell Regulation during Inflammation in Type 1 Diabetes

The autoimmune destruction of the pancreatic islet b cells is due to a targeted lymphocyte attack. Different T cell subsets communicate with each other and with the insulin-producing b cells in this process, with evidence not only of damage to the tissue cells but also of lymphocyte regulation. Here we explore the various components of the immune response as well as the cellular interactions that are involved in causing or reducing immune damage to the b cells. We consider these in the light of the possibility that understanding them may help us identify therapeutic targets to reduce the damage and destruction leading to type 1 diabetes. receptors, engagement of which may amplify b cell destruction contributing to their own destruction. Interestingly, damaged and functional islets coexist. Immune regulatory cells and regulatory mechanisms induced by islet cells counterbalance inflammation. Communication between immune cells and resident islet b cells during inflammation is dependent on the pancreatic microenvironment.
Construction of a fusion gene containing hepatitis B virus L gene and Mycobacterium tuberculosis Ag85B gene and its expression in Pichia pastoris

This study aimed at exploring the method of secretory expression of hepatitis B virus L gene and Mycobacterium tuberculosis Ag85B fusion gene in Pichia pastoris GS115, and preliminary tests of LAg85B fusion protein immunoreactivity. The hepatitis B Virus genome extracted from HBsAg positive serum and genome of M. tuberculosis H37Rv was used as template to amplify L and Ag85B gene. LAg85B fusion gene was cloned into vector pPICZαC and the expression plasmid pPICZαC-L-Ag85B was constructed. After linearization, the plasmid was transformed into P. pastoris GS115 by electroporation. SDS-PAGE and Western blot were used to analyze the expression of protein. The purified fusion protein L-Ag85B was respectively assayed with serum containing anti-HBsAg or anti-Ag85B by ELISA. The recombinant vector was confirmed by sequencing and enzyme digestion. The results of SDS-PAGE and Western blot showed that the recombinant protein was induced by methanol and stably expressed in P. pastoris , while it has specific reaction with the serum containing anti-HbsAg or anti-Ag85B. However, the successful construction of a recombinant yeast expression vector containing gene coding L protein and Ag85B gene, and expressed in P. pastoris, lays a foundation for further researches on immunogenicity and immune protection by the new type of Hepatitis B-Tuberculosis combined vaccine. Key words: Hepatitis B virus, mycobacterium tuberculosis, L gene, Ag85B gene, Pichia pastoris, combined vaccine.
Kempson Language as tools for interaction : Grammar and the dynamics of ellipsis resolution 1

In this paper we explore the consequences of defining natural-language syntax as procedures for context-dependent interpretation as argued within Dynamic Syntax. Dynamic Syntax is a formalism where both representations of content and context are defined dynamically and structurally, with time-linear growth across sequences of partial trees as the core notion, presumed to be manipulated by both speaker and hearer alike. The challenge of modelling the notorious heterogeneity of ellipsis effects in conversational dialogue is taken as a case study for establishing the appropriate concept of context. In the light of the success of these assumptions in capturing the diversity of ellipsis within an overall explanation, we argue that foundational assumptions like the competence/ performance distinction as regards the nature of linguistic knowledge need to be reconsidered. We argue that the grammar needs to be defined in action-based terms with incrementality and context-dependence as crucial explanatory notions of syntactic/semantic phenomena. As a consequence of taking this perspective, we argue that success in communication may rest in the ongoing interaction between participants, as underpinned by low-level mechanisms of language use like the grammar, rather than in recognising some intended propositional content.
Bcp 1 is the Nuclear Chaperone of the 60 S ribosomal protein Rpl 23 in Saccharomyces cerevisiae

Eukaryotic ribosomes are composed of rRNAs and ribosomal proteins. Ribosomal proteins are translated in the cytoplasm and imported into the nucleus for assembly with the rRNAs. It has been shown that chaperones or karyopherins responsible for import can maintain the stability of ribosomal proteins by neutralizing unfavorable positive charges and thus facilitate their transports. Among 79 ribosomal proteins in yeast, only few are identified with specific chaperones. Besides the classic role in maintaining protein stability, chaperones have additional roles in transport, chaperoning the assembly site, and dissociation of ribosomal proteins from karyopherins. Bcp1 has been shown necessary for the export of Mss4, a PI4P 5-kinase, and required for ribosome biogenesis. However, its specific function in ribosome biogenesis was not described. Here, we show that Bcp1 dissociates Rpl23 from the karyopherins and associates with Rpl23 afterward. Loss of Bcp1 causes instability of Rpl23 and deficiency of 60S Bcp1 is the Nuclear Chaperone of the 60S ribosomal protein Rpl23 in Saccharomyces cerevisiae Ya-Han Ting 1 , Ting-Jun Lu 1 , Arlen W. Johnson 2 , Jing-Ting Shie, Bo-Ru Chen 1 , Suresh Kumar.S 1,3 , Kai-Yin Lo †1
Algorithm for Computation of Electromagnetic Fields of an Accelerated Short Bunch inside a Rectangular Chamber

We discuss the feasibility of an application of an implicit finite-difference approximation to calculate the fields of a relativistic bunch moving with no restriction inside a vacuum chamber. We assume that a bunch trajectory is not straight but is inside a vacuum chamber or its branch. The bunch can be deflected by the fields of bending magnets. The bunch can be short enough to produce coherent synchrotron radiation (CSR). Accelerator physicists believe that electromagnetic phenomena of charged beams are governed by Maxwell's equations together with Newton's equations for particle dynamics. To understand the behavior of the beams and radiated fields we just need to find a solution to these equations for the case, which can fully describe the real accelerator environment. So, at first we make a model, which contains all the necessary components, but at the same time can be easily 'inserts' into the equations. Sometimes, it is possible to find analytical solutions, but usually they are only work for one-dimensional cases and rarer for two-dimension cases. To find a solution in general we may transform the equations into a equivalent finite-difference form and solve them using computers. We can find a lot of finite-difference schemes, which approximate Maxwell'smore » equations since the first one that was published in 1966. Most of them are so called explicit schemes. That means that the value of the field at the new time step is calculated only by the field values at the previous time step. Stability conditions for these schemes do not allow a time step to be greater than or equal to a space (mesh) step. This limitation brings an additional troublesome effect for short wavelengths compared a mesh step. We state that this effect works like a frequency dispersion media, which is 'hidden' in the finite-difference equation. « less
Intracellular Compartments Harboring GLUT 4 Where Is GLUT 4 Localized Inside Muscle and Fat Cells ?

Glucose transport is rate limiting for dietary glucose utilization by muscle and fat. The glucose transporter GLUT4 is dynamically sorted and retained intracellularly and redistributes to the plasma membrane (PM) by insulin-regulated vesicular traffic[11_TD$DIFF], or ‘GLUT4 translocation’. Here we emphasize recent findings in GLUT4 translocation research. The application of total internal reflection fluorescence microscopy (TIRFM) has increased our understanding of insulin-regulated events beneath the PM, such as vesicle tethering and membrane fusion. We describe recent findings on Akt-targeted Rab GTPase-activating proteins (GAPs) (TBC1D1, TBC1D4, TBC1D13) and downstream Rab GTPases (Rab8a, Rab10, Rab13, Rab14, and their effectors) along with the input of Rac1 and actin filaments, molecular motors [myosinVa (MyoVa), myosin1c (Myo1c), myosinIIA (MyoIIA)], and membrane fusion regulators (syntaxin4, munc18c, Doc2b). Collectively these findings reveal novel events in insulin-regulated GLUT4 traffic[12_TD$DIFF]. remodeling that tethers GLUT4 vesicles beneath the PM. Additional proteins may also fine-tune actin remodeling through tropomyosin3.1 and tropomodulin3 via Akt2 input.
PLANNING AND EVALUATING PARTICIPATORY FLOOD RISK MANAGEMENT

The EU Flood Risk Management Directive aims at an active involvement of interested parties in the setting up flood risk management plans. It is currently being implemented in the EU Member States. Thus, decision makers and authorities have to find appropriate tools for a communication and participation process which is one of the requirements of the directive. Two approaches for risk communication within flood risk management are presented in this paper: • an indicator based model for the assessment of stakeholder cooperation and the institutional framework; • the concept of social milieus to ensure a tailor-made participation campaign. The indicator based model is a benchmarking tool to evaluate the performance of flood risk management systems in regard to risk governance principles. The concept of social milieus was used to gain a picture of people living in the test case regions and to use this knowledge to plan information and participation activities. This paper presents the approach and results of the ERA-Net CRUE project IMRA (Integrative flood risk governance approach for improvement of risk awareness). The conceptual framework of the project was tested in river basins in Germany, Austria and Italy. In all three case studies the elements of the communication strategy that were implemented were the start of an information and communication process which aimed at involving the stakeholders as well as the public. In general, the project activities had some impact, however this shall not be over-estimated and have to be carefully distinguished between the case studies.
Root dynamics and global change : seeking an ecosystem perspective

SUMMARY Changes in the production and turnover of roots in forests and grasslands in response to rising atmospheric CO2 concentrations, elevated temperatures, altered precipitation, or nitrogen deposition could be a key link between plant responses and longer-term changes in soil organic matter and ecosystem carbon balance. Here we summarize the experimental observations, ideas, and new hypotheses developed in this area in the rest of this volume. Three central questions are posed. Do elevated atmospheric C02, nitrogen deposition, and climatic change alter the dynamics of root production and mortality? What are the consequences of root responses to plant physiological processes? What are the implications of root dynamics to soil microbial communities and the fate of carbon in soil? Ecosystem-level observations of root production and mortality in response to global change parameters are just starting to emerge. The challenge to root biologists is to overcome the profound methodological and analytical problems and assemble a more comprehensive data set with sufficient ancillary data that differences between ecosystems can be explained. The assemblage of information reported herein on global patterns of root turnover, basic root biology that controls responses to environmental variables, and new observations of root and associated microbial responses to atmospheric and climatic change helps to sharpen our questions and stimulate new research approaches. - New hypotheses have been developed to explain why responses of root turnover might differ in contrasting systems, how carbon allocation to roots is controlled, and how species differences in root chemistry might explain the ultimate fate of carbon in soil. These hypotheses and the enthusiasm for pursuing them are based on the firm belief that a deeper understanding of root dynamics is critical to describing the integrated response of ecosystems to global change.
Incidences of preterm delivery < 37 weeks in the second pregnancy based on timing of preterm delivery in the first pregnancy

STUDY DESIGN: In a retrospective cohort of consecutive pregnancies among 51,086 women in Utah (2002-2010), binary relative risk regression was performed to examine the risk of preterm delivery (PTD;<37 weeks) in the second observed delivery by PTD in the first, adjusting for maternal age, race/ethnicity, prepregnancy body mass index, insurance, smoking, alcohol and/or drug use, and chronic disease. Analyses were also performed stratified by prior preterm delivery subtype: spontaneous, indicated, or no recorded indication.
Alternative angular variables for suppression of QCD multijet events in new physics searches with missing transverse momentum at the LHC

We introduce three alternative angular variables-denoted by $\tilde{\omega}_\text{min}$, $\hat{\omega}_\text{min}$, and $\chi_\text{min}$-for QCD multijet event suppression in supersymmetry searches in events with large missing transverse momentum in proton-proton collisions at the LHC at CERN. In searches in all-hadronic final states in the CMS and ATLAS experiments, the angle $\Delta\varphi_i$, the azimuthal angle between a jet and the missing transverse momentum, is widely used to reduce QCD multijet background events with large missing transverse momentum, which is primarily caused by a jet momentum mismeasurement or neutrinos in hadron decays-the missing transverse momentum is aligned with a jet. A related angular variable-denoted by $\Delta\varphi^*_\text{min}$, the minimum of the azimuthal angles between a jet and the transverse momentum imbalance of the other jets in the event-is used instead in a series of searches in all-hadronic final states in CMS to suppress QCD multijet background events to a negligible level. In this paper, before introducing the alternative variables, we review the variable $\Delta\varphi^*_\text{min}$ in detail and identify room for improvement, in particular, to maintain good acceptances for signal models with high jet multiplicity final states. Furthermore, we demonstrate with simulated event samples that $\hat{\omega}_\text{min}$ and $\chi_\text{min}$ considerably outperform $\Delta\varphi^*_\text{min}$ and $\Delta\varphi_i$ in rejecting QCD multijet background events and that $\hat{\omega}_\text{min}$ and $\tilde{\omega}_\text{min}$ are also useful for reducing the total standard model background events.
Hydrothermal ageing of glass/epoxy composites for wind turbine blades

In this work, a glass/epoxy material system commonly applied in wind turbine design was used to evaluate damage processes brought by water ingression during service life. Composite short-beams and neat epoxy beams and dog-bones were conditioned by water immersion at 50o until saturation and tested both statically and in fatigue. By comparing results from mechanical tests with those from reference specimens, significant fibre-matrix interface damage was identified, with reductions of up to 34% on the static strength and fatigue life reduction of up to three orders of magnitude. On the other hand, neat epoxy specimens showed a lower degree of damage, with up to 20% lower moduli and strength properties. Microscopic observations of conditioned specimens point out to extensive debonding on composite specimens after immersion, while neat epoxy specimens show signs of colour changes possibly due to hydrolytic attack. Lastly, changes in the glass transition temperature of the resin due to water ingression are assessed through the DMA technique. From the results, apart from a Tg reduction brought by material degradation, additional relaxation peaks brought by phase changes in the absorbed water molecules were identified.
Fractional integral inequalities involving convexity

Here we present general integral inequalitites involving convex and increasing functions applied to products of functions. As specific applications we derive a wide range of fractional inequalities of Hardy type. These involve the left and right: Erdélyi-Kober fractional integrals, mixed Riemann-Liouville fractional multiple integrals. Next we produce multivariate Poincaré type fractional inequalitites involving left fractional radial derivatives of Canavati type, Riemann-Liouville and Caputo types. The exposed inequalities are of Lp type, p ≥ 1, and exponential type.
Cervical Cancer Patients Treated with Radiotherapy in Larger Patient-Load Hospitals 1 Have Better Treatment Outcomes than Those Treated at Smaller Patient-Load Hospitals : 2 Does this Reflect Differences in the Standard of Care ?

5 OBJECTIVE: 6 We investigated the effects of hospital patient-loa d n the standard of care (SOC) and treatment 7 outcomes of cervical cancer patients treated primar ily with radiotherapy (RT) in hospitals of 8 different patient load, and identified factors that may contribute to survival differences between 9 hospitals. 10 11 METHODS: 12 We used the Taiwan Cancer Registry database to extr act data on a total of 2,582 International 13 Federation of Gynecology and Obstetrics (FIGO) stag e IB to IVA patients with uterine cervical 14 cancer diagnosed in 2007–2013 who underwent primari ly curative RT (with or without 15 chemotherapy). We explored associations between hos pital patient-load, clinical parameters, the 16 type of care given, and survival. 17 18 RESULTS: 19 Patients who received treatment at small and medium patient-load hospitals ( ≤5 cases annually) 20 were older and had more advanced-stage disease than ot er patients. Positive associations were 21 evident between the use of chemotherapy and brachyt herapy and hospital patient-load. Patients 22 treated at hospitals with large patient-load (>5 ca ses annually) experienced better overall survival 23 than those treated at small or medium patient-load hospitals (p<0.001). Stepwise addition of 24 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 2 variables to multivariable analyses indicated that greater use of chemotherapy and brachytherapy 1 were major contributors to the better survival of p atients treated at large patient-load hospitals. 2 However, larger hospital patient-load per se (>5 vs . ≤5 cases annually) was also independently 3 prognostic for better survival of patients with bul ky tumors or advanced-stage disease. 4
Study of Aerosol Charging in Electro-Aerosol Generator

Abstract The urgency of the study is conditioned by the necessity of perfection of the methods of electro-aerosol disinfection and disinsection of the air and the surfaces of premises, medical and preventive treatment of animals, and plant protection. The objective of the paper is aimed at revealing the regularities of electro-physical processes when charging an aerosol in electro-aerosol generators, improvement of the methods of electro-aerosol generation. The leading approach to the research of this problem is mathematical modelling of electrotechnical, dynamic and kinetic processes in electro-aerosol generators, allowing revealing the basic regularities of electro-aerosol generation. Experimental studies are aimed at assessment of the main characteristic of the electro-aerosol generator – convection current. As a result of the studies, a mathematical model of electro-aerosol generation with the mechanical method of atomization was obtained. The regularities of charging a fluid thread, arising at the edge of the generator, when applying electric field. The configuration of the electric field of cylindrical electrodes, taking into account the influence of the bulk charge of the electro-aerosol cloud, was considered. Electrostatic pressure of the electric field of the generator on fluid streams was taken into consideration. An equation for determining the average radius of drops of the electro-aerosol during mechanical atomization by the perforated cage was obtained. The mathematical model of electro-aerosol generation is obtained in the form of the equation of convection current, being one of the basic characteristics of the process of electro-aerosol generation, allowing defining the efficiency of electrization of aerosol particles and the degree of their fragmentation. Theoretical calculations are verified experimentally. Materials of the paper can be useful for the researchers, post-graduate students, engineers, engaged in designing, manufacturing and exploiting electro-aerosol equipment.