Miracle-dz/UniFAR-FTUs huggingface dataset:
The Solar Neighborhood. XLV. The Stellar Multiplicity Rate of M Dwarfs Within 25 pc

We present results of the largest, most comprehensive study ever done of the stellar multiplicity of the most common stars in the Galaxy, the red dwarfs. We have conducted an all-sky volume-limited survey for stellar companions to 1120 M dwarf primaries known to lie within 25 pc of the Sun via trigonometric parallaxes. In addition to a comprehensive literature search, stars were explored in new surveys for companions at separations of 2″–300″. A reconnaissance of wide companions to separations of 300″ was done via blinking archival images. I-band images were used to search our sample for companions at separations of 2″–180″. Various astrometric and photometric methods were used to probe the inner 2″ to reveal close companions. We report the discovery of 20 new companions and identify 56 candidate multiple systems. We find a stellar multiplicity rate of 26.8 ± 1.4% and a stellar companion rate of 32.4 ± 1.4% for M dwarfs. There is a broad peak in the separation distribution of the companions at 4–20 au, with a weak trend of smaller projected linear separations for lower mass primaries. A hint that M-dwarf multiplicity may be a function of tangential velocity is found, with faster moving, presumably older, stars found to be multiple somewhat less often. We calculate that stellar companions make up at least 17% of mass attributed to M dwarfs in the solar neighborhood, with roughly 11% of M-dwarf mass hidden as unresolved companions. Finally, when considering all M-dwarf primaries and companions, we find that the mass distribution for M dwarfs increases to the end of the stellar main sequence.
Association between Proinflammatory Markers, Leukocyte–Endothelium Interactions, and Carotid Intima–Media Thickness in Type 2 Diabetes: Role of Glycemic Control

Glycated hemoglobin monitorization could be a tool for maintaining type 2 diabetes (T2D) under control and delaying the appearance of cardiovascular events. This cross-sectional study was designed to assess the role of glycemic control in modulating early-stage markers of cardiovascular complications. One hundred and eight healthy controls and 161 type 2 diabetic patients were recruited and distributed according to their glycemic control, setting the threshold at 6.5% (good control). Biochemical and anthropometrical parameters were registered during the initial visit, and peripheral blood was extracted to obtain polymorphonuclear cells and analyze inflammatory markers, adhesion molecules, leukocyte–endothelium interactions, and carotid intima–media thickness. Correlations between these parameters were explored. We found that inflammatory markers and adhesion molecules were augmented in type 2 diabetic subjects with poor glycemic control. Polymorphonuclear leukocytes interacted more with the endothelium in the diabetic population, and even more significantly in the poorly controlled subjects. In parallel, carotid intima–media thickness was also increased in the diabetic population, and the difference was greater among poorly controlled subjects. Finally, correlation measurement revealed that carotid intima–media thickness was related to glycemic control and lipid metabolism in diabetic patients. Our results suggest that glycemic control delays the onset of cardiovascular comorbidities in diabetic subjects.
Tumor suppressor TSLC 1 inhibits growth , proliferation , invasiveness and angiogenesis in nude mice xenografted tumor of Eca 109 cells

Tumor suppressor in lung cancer 1 (TSLC1) is a novel tumor suppressor gene whose inactivation is implicated in the occurrence, invasion, metastasis and prognosis of esophageal cancer. TSLC1 was studied by comparing the tumor formation of TSLC1 transfectant and control cells in nude mice. Compared with blank group and mock group, tumor size and infiltrating range of transfected group was less, differentiation of tumor tissue was slightly better, and differences of tumor angiogenesis was worse. There was no obvious difference between blank group and mock group. We have shown TSLC1 gene inhibited the growth proliferation, infiltration and angiogenesis of Eca109 cells.
The Therapeutic Alliance in Digital Mental Health Interventions for Serious Mental Illnesses: Narrative Review

Background Digital mental health interventions offer unique advantages, and research indicates that these interventions are effective for a range of mental health concerns. Although these interventions are less established for individuals with serious mental illnesses, they demonstrate significant promise. A central consideration in traditional face-to-face therapies is the therapeutic alliance, whereas the nature of a digital therapeutic alliance and its relationship with outcomes requires further attention, particularly for individuals with serious mental illnesses. Objective This narrative review aims to encourage further consideration and critical evaluation of the therapeutic alliance in digital mental health, specifically for individuals with serious mental illnesses. Methods A narrative review was conducted by combining 3 main areas of the literature: the first examining the evidence for digital mental health interventions for serious mental illnesses, the second illuminating the nature and role of the therapeutic alliance in digital interventions, and the third surrounding practical considerations to enhance a digital therapeutic alliance. Results Results indicated that a therapeutic alliance can be cultivated in digital interventions for those with serious mental illnesses, but that it may have unique, yet-to-be-confirmed characteristics in digital contexts. In addition, a therapeutic alliance appears to be less directly associated with outcomes in digital interventions than with those in face-to-face therapies. One possibility is that the digital therapeutic alliance is associated with increased engagement and adherence to digital interventions, through which it appears to influence outcomes. A number of design and implementation considerations may enhance the digital therapeutic alliance, including human support and technological features. Conclusions More research is required to further understand the nature and specific role of a therapeutic alliance in digital interventions for serious mental illnesses, particularly in informing their design. This review revealed several key research priorities to advance the therapeutic alliance in digital interventions.
Single-feed dual-band circularly polarised microstrip antenna

A novel technique for obtaining dual-band circular polarisation (CP) radiation of a single-feed circular microstrip antenna is proposed and demonstrated. By embedding two pairs of arc-shaped slots of proper lengths close to the boundary of a circular patch, and protruding one of the arc-shaped slots with a narrow slot, the circular microstrip antenna can perform dual-band CP radiation using a single probe feed. Details of the antenna design and experimental results are presented.
Association between GDF15, poverty and mortality in urban middle-aged African American and white adults

Mortality disparities are influenced by race and poverty. There is limited information about whether poverty influences biologic markers of mortality risk. Emerging data suggests that growth differentiation factor 15 (GDF15) is associated with mortality; however, the interplay between GDF15, sociodemographic factors and mortality is not known. We sought to evaluate the interactions between GDF15 and sex, race and poverty status on mortality. Serum GDF15 was measured in 1036 African American and white middle-aged men and women above and below 125% of the Federal poverty status from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. Multivariable adjusted Cox regression models were used to assess the association between log-transformed GDF15 (logGDF15) and 12-year mortality outcomes (all-cause, cardiovascular- and cancer-specific outcomes) and interactions with sex, race and poverty status. Likelihood ratio tests were used to assess significance of the interaction terms. Median GDF15 was 655.2 pg/mL (IQR = 575.1). During 12.2 years of follow-up, 331 died of which 94 cardiovascular- and 87 were cancer-specific deaths. One unit of increase in logGDF15 was associated with a hazard ratio for all-cause mortality, cardiovascular- and cancer-specific mortality of 2.26 (95% confidence interval [CI], 1.94–2.64), 2.74 (95%CI, 2.06–3.63) and 1.41 (95%CI, 1.00–2.00), respectively. There was an interaction between logGDF15 and poverty status on all-cause mortality (p<0.05). The GDF15×poverty status interaction term improved model calibration for all-cause mortality. Our study provides the first evidence that the effect of elevated GDF15 on all-cause mortality is modified by poverty status.
How does health policy affect practice at a sport mega event? A study of policy, food and drink at Euro 2016

ABSTRACT From a public health perspective, there are growing concerns about the commercial arrangements between sports events and companies which sell ultra-processed food and drink. In particular, companies are accused of connecting products that are perceived as unhealthy with sport and physical activity that is perceived as healthy. This study examined the tensions and conflicts between health promotion policy and the marketing and consumption reality at the 2016 European Championship football tournament in France. This study is informed theoretically by a critical, political economy lens. Discourse analysis, semiotic analysis, venue analysis and participant observation were employed to gather data from relevant policy and event management plans, sponsor advertisements, site architecture, food and drink offerings and displays at stadia and fan zones. These sources were assessed for the way they encouraged healthy or unhealthy consumption behaviours. The analysis found that the health advice promoted by the French government and the tournament owners (Union of European Football Associations) differed markedly from the reality at the points of consumption. Unhealthy products dominated inside the stadia and fan zones sampled. In many instances, there were little or no healthy foods on display for customers. Despite a self-proclaimed status as having ‘healthy stadia’, a limited vision of health at Euro 2016 was promoted, which was largely restricted to the attempted provision of smoke-free spaces. This raises questions for sport mega events which are in receipt of public funding and which claim to promote health. This study encourages policy-makers, sports funders and consumers to critically evaluate health claims made by sport events and sponsors.
What are parental condition‐transfer effects and how can they be detected?

While it has been recognized for many years that parental condition can influence offspring performance, recent research on adaptive parental effects has focused primarily on anticipatory effects, whereby parents adjust the phenotype of their offspring for the anticipated environment. Here, we make the case that condition transfer is a widespread and important type of adaptive parental effect, and endeavour to clarify how such effects should be interpreted and studied. Some authors have suggested that condition‐transfer effects result simply from resource limitation constraints (passive condition transfer, or transmissive effects). However, condition transfer can also reflect evolved parental investment strategies (active condition‐transfer effects). In some species, such strategies can involve cryptic mechanisms such as epigenetic inheritance. As recently shown in this journal by Engqvist and Reinhold, condition‐transfer effects can be obscured by anticipatory effects and interactions between the effects of parental and offspring environments. Nonetheless, we argue that these complications can be largely overcome by examining a broad range of ecologically relevant environments in both parental and offspring generations. This can be accomplished by adapting a powerful methodology from the nutritional sciences—the geometric framework—to research on parental effects.
Gastric Microbiota in a Low–Helicobacter pylori Prevalence General Population and Their Associations With Gastric Lesions

INTRODUCTION: Non–Helicobacter pylori microbiota might account for some cases with unexplained chronic gastritis that may in a minority eventually progress to gastric cancer through the Correa cascade. We characterized gastric microbiota by describing the normal stomach, compared it with early precancerous lesions and other disease states, and assessed whether H. pylori status affects bacterial diversity. METHODS: In a population-based study of those with and without gastrointestinal symptoms, cytology brush samples were collected during endoscopy from 316 individuals. Mucosal status was classified as normal mucosa (171), nonatrophic H. pylori gastritis (33), atrophic gastritis (12), or antral chemical gastritis (61). The 16S rRNA gene sequencing and analysis were performed to characterize the microbiota. RESULTS: Microbiota in atrophic gastritis and nonatrophic H. pylori gastritis stomachs were dysbiotic and differed from those in the normal stomach (P = 0.001). The normal stomach had the highest microbial diversity, followed by antral chemical gastritis. The atrophic gastritis and chronic H. pylori gastritis groups had the lowest diversity, a difference that was statistically significant (P = 0.01). Besides H. pylori, non–H. pylori bacteria accounted for group differences. Microbial network analysis showed that the normal group network was most highly connected, whereas the H. pylori gastritis group had the lowest connection. We found an increasing positive co-occurrence of oral bacteria in the stomach because samples deviated from the normal network, some of which were pathogens. The H. pylori–negative group had the highest microbial diversity (Shannon index) compared with the H. pylori–positive group (P = 0.001). DISCUSSION: In this low–H. pylori prevalence general population, the gastric mucosal microbiota of the normal stomach differed significantly from those with nonatrophic or atrophic gastritis. There was an increasing abundance of pathogenic bacteria from the normal state to early precancerous states.
Repository Personality and employee selection

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Increased expression of interleukin‐23A in lesional skin of patients with atopic dermatitis with psoriasiform reaction during dupilumab treatment

Atopic dermatitis (AD) and psoriasis (Pso) are chronic diseases that may be phenotypes at polar ends of the T-cell inflammatory milieu. The two diseases represent two distinct pathogenetic entities, with type 2 T helper (Th2) cytokines interleukin (IL)-4, IL-13, IL-31, and possibly IL-22 mainly implicated in AD, and Th17 cytokines IL-17 and IL-23 in Pso.3 However, a range of phenotypes with overlapping clinical patterns exist, possibly reflecting a variable expression of T-cell axes. Dupilumab is a human monoclonal antibody directed against the alpha subunit of IL-4 receptor, approved for the treatment of moderate-to-severe AD.
Investigating the Relationship between Intellectual Capital and Knowledge Productivity in Iran Insurance Branches in Guilan Province - Iran

Development of information technology and communication networks has increased the share of knowledge and information use at the global level greatly. In this regard, one of the most important resources of company is intellectual capital. Today, intellectual capital is changing to an important source of economic growth. Therefore, managers are required to measure intellectual capital as an important criterion to increase business performance of organizations. The purpose of conducting of the present study is to assess the quality of having meaning of the relationship between intellectual capital and the productivity of knowledge in Iran insurance branches of Guilan Province. In order to achieve the objective, the measurement of the indexes of the intellectual capital dimensions (including human capital, structural capital, social capital) and their relationship with productivity based on the conceptual model of present research was used. Accordingly, in addition to comprehensive review of the literature related to intellectual capital and productivity of 360 people out of a total statistical population of 200 people were randomly sampled. Then by collecting required data and information by the questionnaire in the form of research and field method as well as using SPSS software to carry out statistical tests the measurement of dimensions of intellectual capital, knowledge productivity of Iran insurance branch of Guilan province was conducted. The result of research shows that there is a positive and meaningful relationship between the dimension of human capital and knowledge productivity, and by human capital increasing, knowledge productivity will increase as well. There is a positive relationship between organizational capital and knowledge productivity, and by increasing organizational capital, knowledge productivity will increase. There is a significant relationship between social capital and knowledge productivity, and by increasing social capital, knowledge productivity will increase. Therefore, there is a significant relationship between dimension of intellectual capital and knowledge productivity, and by increasing intellectual capital, knowledge productivity will increase.
A Comparison of the Validity of Very Brief Measures of the Big Five/Five-Factor Model of Personality

Personality is of great lay, clinical, and research interest with important functional implications. The field has largely settled on five- or six-factor models as being largely sufficient for descriptive purposes, at least in W.E. I.R. D settings and, as such, numerous measures have been created of varying length and breadth. For a number of reasons, however, super-short forms have come to be quite popular in research endeavors with a number created in the past 20 years. The goal of the present study was to compare the time with completion and general psychometric properties of these measures, as well as examine their convergence with one another and with longer measures in an online community sample (N = 494). Generally, the psychometric properties of the measures varied considerably in terms of internal consistency and convergence with one another. The brief measures demonstrated mostly adequately convergence with longer measures. Despite this convergence, longer measures were found to contain considerably more variance that was not accounted for by brief measures. We consider the advantages and disadvantages of these measures and suggest that longer measures be prioritized whenever possible.
Automated, Objective Assessment of Pilot Performance in Simulated Environment

Nowadays flight simulators offer tremendous possibilities for safe and cost-effective pilot training, by utilization of powerful, computational tools. Due to technology outpacing methodology, vast majority of training related work is done by human instructors. It makes assessment not efficient, and vulnerable to instructors’ subjectivity. The research presents an Objective Assessment Tool (gOAT) developed at the Warsaw University of Technology, and tested on SW-4 helicopter flight simulator. The tool uses database of the predefined manoeuvres, defined and integrated to the virtual environment. These were implemented, basing on Aeronautical Design Standard Performance Specification Handling Qualities Requirements for Military Rotorcraft (ADS-33), with predefined Mission-Task-Elements (MTEs). The core element of the gOAT enhanced algorithm that provides instructor a new set of information. In details, a set of objective flight parameters fused with report about psychophysical state of the pilot. While the pilot performs the task, the gOAT system automatically calculates performance using the embedded algorithms, data registered by the simulator software (position, orientation, velocity, etc.), as well as measurements of physiological changes of pilot’s psychophysiological state (temperature, sweating, heart rate). Complete set of measurements is presented on-line to instructor’s station and shown in dedicated graphical interface. The presented tool is based on open source solutions, and flexible for editing. Additional manoeuvres can be easily added using guide developed by authors, and MTEs can be changed by instructor even during an exercise. Algorithm and measurements used allow not only to implement basic stress level measurements, but also to reduce instructor’s workload significantly. Tool developed can be used for training purpose, as well as periodical checks of the aircrew. Flexibility and ease of modifications allow the further development to be wide ranged, and the tool to be customized. Depending on simulation purpose, gOAT can be adjusted to support simulator of aircraft, helicopter, or unmanned aerial vehicle (UAV). Keywords—Automated assessment, flight simulator, human factors, pilot training.
Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications

Introduction: Colorectal Cancer (CRC) accounts for 9% of cancer deaths globally. Hormonal pathways play important roles in some cancers. This study investigated the association of CRC expression of neurotensin (NTS), NTS receptors 1 and 3 (NTSR1 and NTSR3) and clinical outcomes. Methods: A prospective cohort study which quantifies the protein expression of NTS, NTSR1 and NTSR3 in human CRCs using immunohistochemistry. Expression levels were then compared with clinico-pathological outcome including histological grade, overall survival (OS) and disease-free survival (DFS). Results: Sixty-four patients were enrolled with median follow-up of 44.0 months. There was significantly higher expression of NTS in cancer tissue in CRC with higher T stages (p < 0.01), N stages (p = 0.03), and AJCC clinical stages (p = 0.04). There was significantly higher expression of NTS, NTSR1 and NTSR3 in cancer tissue compared to surrounding normal epithelium (median H-score 163.5 vs 97.3, p < 0.01). There was significantly shorter DFS in individuals with CRC with high levels of NTS compared to lower levels of NTS (35.8 months 95% CI 28.7–42.8 months vs 46.4 months 95% CI 42.2–50.5 months, respectively, p = 0.02). Above median NTS expression in cancer tissue was a significant risk factor for disease recurrence (HR 4.10, 95% CI 1.14–14.7, p = 0.03). Discussion: The expression of NTS and its receptors has the potential to be utilised as a predictive and prognostic marker in colorectal cancer for postoperative selection for adjuvant therapy and identify individuals for novel therapies targeting the neurotensinergic pathways. Conclusions: High NTS expression appears to be associated with more advanced CRC and worse DFS.