Miracle-dz/UniFAR-FTUs huggingface dataset:
Uma Abordagem para Identificação de Entidades Influentes em Eventos Comentados nas Redes Sociais Online

Online Social Networks (OSN) allow users to share content of any kind. In these networks, users can be considered as social sensors, where their opinions and comments about an event can be studied (e.g., characterizing events, recognizing influential entities). OSN can be modeled as complex networks, where the entities are represented by the vertices and the edges characterize the connection between them. Using this approach, we can determine which are the most influential entities in the studied context through centrality measures (e.g., Betweenness and Pagerank). Based on this, this article presents an analysis of the most influent entities from the perspective of an event in Online Social Networks and an study of the detected communities. As results we realize that the measures of centrality have different influential entities, this shows that although all the entities are part of the same event, some have greater influence depending on the studied aspect. Regarding the community detection we notice that entities that were grouped together, are directly linked to a sub-event within the studied context. Resumo. Redes Sociais Online (RSO) permitem aos usuários compartilhar conteúdo de qualquer tipo. Nestas redes, os usuários podem ser vistos como sensores sociais, onde suas opiniões e comentários a respeito de um evento podem ser utilizados para estudo (e.g., caracterização de eventos, reconhecimento de entidades influentes). RSO podem ser modeladas como redes complexas, onde as entidades são representadas pelos vértices e as arestas caracterizam a conexão entra elas. Utilizando esta abordagem, podemos determinar quais são as entidades mais influentes no contexto estudado através de medidas de centralidade (e.g., Betweenness e Pagerank). Com base nisto, este artigo apresenta uma análise das entidades mais fluentes sob a perspectiva de um evento em Redes Sociais Online e apresenta um estudo das comunidades detectadas. Como resultados percebemos que as medidas de centralidade apresentam diferentes entidades influentes, isto demonstra que embora todas as entidades façam parte do mesmo evento, algumas tem influência maior dependendo do aspecto estudado. Com relação a detecção de comunidades percebemos que entidades que foram agrupadas juntas, estão diretamente ligadas a um sub-evento dentro do contexto estudado. 1. Introdução Com a disseminação da Internet, as Redes Sociais Online (RSO) emergiram possibilitando a conexão de pessoas através de ambientes virtuais, que disponibilizam recursos XXXVII Congresso da Sociedade Brasileira de Computação
Phage display and experimental brain therapeutics

Phage display, a powerful polypeptide display technology, affords the rapid identification of peptides and proteins that interact with a target of interest The aims of the project were the phage display identification of peptides that interact with a druggable target in a brain disorder (glioblastoma multiforme) and the identification of peptides that serve as targeting vectors for brain delivery. Validation studies were undertaken to qualify the use of a cyclic 7-mer peptide phage library against targets including streptavidin and paracetamol chosen as examples of a large complex and small simple molecule, respectively. With the aim of identifying peptide phages that bind to the luminal surface of brain micro vasculature, a primary in-vitro porcine model of the blood-brain barrier (BBB) comprising primary brain capillary endothelial cells was established and characterised. An in-vivo phage display was undertaken in the rat with the aim of identifying peptide sequences that mediated translocation across the BBB into brain grey matter. A 7-mer cyclic peptide was identified with sequence AC-SYTSSTM-CGGGS that enhanced the uptake of phages into brain grey matter by 4-fold compared to control wild-type phages. This peptide may serve as a novel targeting vector for the delivery of a therapeutic cargo to the brain. Caveolin-1 was identified as a potential new therapeutic target in in-vitro models of grade IV astrocytomas (glioblastoma multiforme), with siRNA knockdown of caveolin-1 associated with reduced glioma cell proliferation and invasiveness. With the caveolin-1 scaffolding domain (aa 81-101 in the caveolin-1 protein) as a target, an in-vitro peptide phage selection was undertaken and identified a series of peptides that bind the scaffolding domain with high affinity. These peptides will serve as a template for the development of low molecular weight peptidomimetics that inhibit caveolin-1 function. In conclusion, the studies in this thesis have demonstrated the utility of phage display in experimental therapeutics of brain disorders.
Muffle atmosphere promoted fabrication of graphene oxide nanoparticle by agricultural waste

Abstract Graphene is a radiant star in the field of nanomaterials. It has gained prominent interest since of its very good mechanical, thermal, optical and electronic possessions. The basic chemical reaction elaborate in the Hummer’s method was the oxidation of graphite, during which harmful toxic gases used to emit. Nowadays green chemistry is blossoming in the field of nanomaterial. In present work, we fabricate graphene oxide (GO) through different agricultural wastes i.e., Rice bran (RB), Sugarcane bagasse (SB), Orange peel (OP), and mixture of all these three wastes i.e., tricomposite agro waste (TAW) were mixed with ferrocene which gave electron transfer reaction to synthesized GO and compared it. At last, we concluded that particle size obtained for OPGO (23.99 nm) > graphite (17.17 nm) > SBGO (15.5 nm) > RBGO (2.235 nm) > TAWGO (1.77 nm). These green strategies are biocompatible and cost effective too. Basic information of GO crystal was obtained by X-ray diffraction (XRD) for determination of crystal structure, scanning electron microscopy (SEM) for morphological study, high resolution transmission electron spectroscopy (HRTEM) used for determine particle size, fourier transform infrared (FTIR) spectroscopy for functional group detection, thermogravametric analysis (TGA)/differential thermal analysis (DTA) for determine thermal stability of GO.
Does Monetary Policy Impact International Market Co-Movements?

We investigate the impact of ECB and FED’s monetary announcements on the extent of comovements in the equity and sovereign CDS markets (as measured by the fraction explained by the first principal component) for a large cross-section of countries over 2007 to 2015. The effect of both announcements is strongly positive during the financial crisis of 2007-2009. ECB interventions lead to stronger comovements in the equity market during 2010 to 2012, but dis-integration in the CDS market during the ECB Quantitative Easing period (2013 to 2015), especially for emerging countries. In contrast, FED announcements are perceived as global factors in the CDS emerging market and are accompanied with an increase in commonalities both when the FED implements and unwinds its unconventional measures. The relation between the global factor and the U.S. market increases during FED interventions, while the same does hold for the European market during ECB announcements. The response to outside monetary policy shocks relates to a country’ degree of openness to the trading of goods and capital flows, but not to its currency exposure. JEL classification: E58, G12, G15
Transcriptional Activation by the Group A Streptococcal Mga Regulator

Title of Dissertation: Dissertation Directed by: Transcriptional Activation by the Group A Streptococcal Mga Regulator Lara Louise Hause, Doctor of Philosophy, 2012 Associate Professor Kevin S. McIver Department of Cell Biology and Molecular Genetics Streptococcus pyogenes (Group A Streptococcus, GAS) is a Gram-positive obligate human pathogen that causes a range of diseases at many different tissue sites. The ability of this organism to colonize and persist within these various niches of the body correlates with broad changes in gene expression. Mga, the multiple gene regulator of GAS, is an important global transcriptional regulator of virulence genes that encode factors promoting adhesion, host cell invasion and immune evasion. Mga directly activates these genes by binding to specific promoter sites that range from 45 to 60 nucleotides in size based on DNAseI footprint analysis; however identified Mga binding sites share less than 50% DNA sequence similarity, making the identification of a consensus Mga binding site difficult. We have identified nucleotides necessary for Mga binding in the Mga-regulated Pemm promoter from the clinically relevant M1 MGAS5005 strain of GAS. Random and directed mutations were assessed for effects on transcription in vivo and DNA binding in vitro. This screen identified predominately Gs and Cs, in two clusters at the 3’ and 5’ end that suggest that Mga binds DNA as a dimer and reduced the Pemm binding site to 35 bp. However directed mutagenesis in other binding sites found that these interactions were not necessarily conserved. These experiments also sought to establish a method to study genome-wide DNA binding and can successfully enrich for Mga-regulated genes. Protein-protein interactions with RNA polymerase are another key component to activate transcription. Functional in vitro transcription assays and in vitro co-purification assays were performed to determine if Mga interacts with either the α C terminal domain or domain 4 of σ. While Mga does appear to make protein-protein contacts with the holoenzyme, they do not occur through either domain alone. The dimerization of Mga through its EIIB domain was established by analytical ultracentrifugation. In vitro transcription assays linked phosphorylation by the phosphoenolpyruvate transferase system to the down regulation of Mga activity. By understanding how Mga interacts with essential elements of its promoters, this study seeks to define Mga's role in regulating virulence in this important human pathogen. Transcriptional Activation by the Group A Streptococcal Mga Regulator By Lara Louise Hause Dissertation submitted to the Faculty of the Graduate School of the University of Maryland, College Park, in partial fulfillment of the requirements for the degree of Doctor of Philosophy 2012
Impacts of Chromium and Selenium-E on Cortisol Levels, Reproductive and productive Efficiency of Baladi Female Goats under Subtropical Conditions.

The present study was conducted during estrous cycle and pregnancy period in Baladi female goats to study the effect of chromium and selenium with vitamin E on blood serum cortisol concentration. Seventy-two of mature Baladi does with age ranged from 2 to 3 years old and the mean body weight was 25.1±1.5 kg was used under two conditions of winter and summer seasons (36 animals/season). The animals were randomly divided into three groups, the 1st group was kept as control and the 2nd group was supplemented by chromium (chromium chloridetrivalent), 0.8 mg/head/day. The 3rd group was intramuscularly injected twice a week with 2ml viteselen®, contained 0.5 mg selenium and 10.7 IU vitamin E (Se-E). Serum cortisol levels were assessed in the three experimental goats during the estrous and pregnancy periods. The results demonstrated that Goats supplementation with Cr or Se-E significantly decreased (P<0.05) serum cortisol concentrations than control during estrous cycle. In addition, Cr mostly lowered (P<0.05) cortisol than control, but Se-E thoroughly increased it during pregnancy. However, under mild season at pro-estrus phase Cr treatment increased cortisol significantly (P<0.05) than control. Also, during pregnancy period Cr decreased cortisol at Mid-Pregnancy and Late-Pregnancy periods; however, Se-E increased cortisol at the Late-Pregnancy period than the control group. Under hot season, Cr treatment decreased (P<0.05) cortisol during estrous cycle, pregnancy period. However, injection of Se-E decreased cortisol during estrous cycle and showed a contrary effect during pregnancy period. On the other side, Reproductive traits of female goats showed that, under mild season conditions Cr or Se-E supplementations did not have any effect on goat’s reproductive traits, in terms of conception rate, kidding rate, fertility rate, prolificacy and fecundity compared to control group. Under hot season conditions, Cr and Se-E improved both of fertility and conception rate, as well as, increased fecundity percentage more than control. Cr group had lowest prolificacy, however; Se-E had the highest one compared to control. Chromium group had significantly (P<0.05) higher birth weight of kids than control and Se-E either at mild or hot season. However, injection of Se-E did not affect litter birth weight under mild and hot conditions.So,It can be concluded that Cr and Se-E supplementation can enhanced the reproductive and productive traits of female Baladi goats under hot season.
Infiltrating granulocytes and resident Muller cells are major sources for suppressor of cytokine signaling (SOCS)1 and SOCS3 production during murine cytomegalovirus (MCMV) retinitis in mice with retrovirus-induced immunosuppression (MAIDS)

©2013, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Office at arvo@arvo.org. 106 Posterior Segment Infection/AIDS-Related Ocular Disease Sunday, May 05, 2013 8:30 AM-10:15 AM Exhibit Hall Poster Session Program #/Board # Range: 126-139/C0131-C0144 Organizing Section: Immunology/Microbiology
KNOWLEDGE AND ATTITUDE OF PARENTS AND SCHOOLS STAFF TOWARDS HEAD LICE INFESTATION IN RIYADH

Background: Head lice infestation is a parasitic skin infection that is commonly prevalent globally, especially in areas with poor economic status. This parasite lives in both human and animal body. This parasite feeds on the blood of host and transmits among different individuals by using of claws of the leg. Objective: To investigate the knowledge and attitudes of parents towards head lice in Riyadh. Subjects and Methods: This is a cross sectional study which was conducted on mothers of school girls in schools in Riyadh, Saudi Arabia. The study was performed using self-administrated questionnaire which was distributed among participants. Results: The prevalence of head lice among children of participants was 56.5%. Appearance of lice
The Membrane Interface as a Structured Compartment and a Substrate for Enzyme Action

Our picture of the biological membrane has changed considerably over the last few decades mainly due to the advancements in instrumentation that allow us to image membranes with an increasing resolution in space and time. Whereas the picture of the membrane since the introduction of the celebrated Singer–Nicolson fluid-mosaic model [1] has always been one imparting the membrane assembly with considerable dynamics and disorder, the current picture is more refined, describing the membrane as a structured bimolecular and fluid flexible sheet with a certain degree of local lateral organization [2–4] in terms of differentiated lipid domains, in some cases called rafts [5]. Although the lipid-bilayer component
THE APPLICATION OF SOCIAL ACCOUNTING IN JORDANIAN HOTELS, THE ROLE IN ACCOUNTING DISCLOSURE AND ITS IMPACT ON THE QUALITY OF THE FINANCIAL STATEMENTS

Aim/Purpose: This paper aims to investigate the application of social accounting in Jordanian hotels, the role in accounting disclosure and its impact on the quality of the financial statements. The primary objective of the study is to determine the extent of applied social responsibility accounting on the accounting disclosure, and the role of applied social responsibility accounting on the quality of financial statements. Background: The research focuses on the effect of applied social responsibility on the accounting disclosure in financial statements, through Intermediate variable (accounting disclosure). Materials and Method s : This study adopted the qualitative method and based on the theoretical framework and previous studies. This paper examines the extent of applied social responsibility accounting on the accounting disclosure, and the role of applied social responsibility accounting on the quality of financial statements. Results : The findings showed that Jordanian hotels provide good care for their employees in most areas. This is what distinguishes the hotel sector from other sectors. Conclusion: The social performance of hotel workers shows that Jordanian hotels provide good care for their employees in most areas. This is what distinguishes the hotel sector from other sectors.the role of Jordanian hotels in the scope of social services appear substandard performance, hotels Does not do its duty as required in terms of providing financial and moral support to charities in the area in which it operates, or the construction of health and educational centers, Most of this support goes to conferences and seminars that highlight the role of these hotels in the field of environmental protection or only is to allow university and school students to training and conduct field visits to hotel facilities.
Proximity to rainforest enhances pollination and fruit set in orchards

Summary 1 Tropical rainforests are potential reservoirs of insects that could enhance crop pollination, but only a few instances of the provision of such services by tropical rainforest insects have been reported. Our field study aimed to determine the relative importance of such insects to the pollination of macadamia Macadamia integrifolia and longan Dimocarpus longan crops on the Atherton Tableland, north Queensland, Australia. 2 We quantified initial fruit set, a measure of pollination success, in treatments designed to assess the relative importance of the possible modes of pollination. The treatments were applied in orchards that varied in distance from rainforest, in order to compare the effects of the contrasting pools of available pollen vectors. We also recorded the insect species present and estimated the number of visits each made to flowers in crops near and far from rainforest. 3 For both crops there was an interaction between pollination treatment and distance from rainforest. Maximum fruit set was only achieved when pollen vectors had access to flowers and orchards were close to rainforest. Exclusion of pollinators near rainforest reduced initial fruit set to a greater extent than exclusion of pollinators far from rainforest. 4 We confirmed that pollen transfer in macadamia is by autogamous self-pollination and by pollen vectors, but our design did not distinguish among pollen vectors. The only abundant insects in macadamia orchards were honeybees Apis mellifera. There were more honeybee visits to macadamia flowers in orchards near rainforest than far from rainforest, but we detected no relationship between honeybee visits and initial macadamia fruit set in our sample of observations on a per raceme basis. More detailed studies are needed to identify the pollen vector responsible for enhanced pollination of macadamia near rainforest. 5 We established for the first time that pollen transfer in longan is by a combination of autogamous self-pollination, wind and bees. Longan flowers were visited by stingless bees and honeybees but only stingless bees had a positive relationship with initial longan fruit set and higher visitation rates near rainforest than far from rainforest. This suggests that enhanced pollination in longan near rainforest resulted primarily from a more abundant supply of stingless bees from the rainforest. 6 Synthesis and applications. By demonstrating that tropical rainforest can act as a reservoir of pollen vectors that benefit crops, our study highlights the existence of a largely unrecognized resource available to agriculture. At the same time our results make a significant contribution to the growing database of studies that underscore the importance of tropical rainforest conservation. Policy and management aimed at sustainable use of this resource would satisfy the goals both of agriculturalists, to improve crop yields, and conservationists, to conserve tropical rainforest.
Simultaneous Study of VLF/ULF Anomalies Associated with Earthquakes in Japan

We carried out a simultaneous study of ground-based magnetic field and lower ionospheric anomalies during major earthquakes occurring around Japan in 2010 and 2012. Ultra Low Frequency (ULF) geomagnetic field waveforms of Esashi station and Very Low Frequency (VLF) Japanese transmitter (JJY) electric signal amplitude received in Moshiri station Hokkaido during nighttime (22:00-02:00 LT) were used to minimize the local interference. Twenty earthquakes having magnitude greater than 5.5 were considered for the data analysis for two years. Nighttime amplitude fluctuations and polarization from the received VLF transmitter signal amplitude and ULF magnetic field respectively were calculated to identify anomalous signatures in relation to every earthquake. We found most earthquakes analyzed indicating VLF amplitude anomalies simultaneously occurred with ULF magnetic field anomalies within a week prior to the earthquakes. Stronger anomalies were observed for larger magnitude and shallower earthquakes. Focal mechanism of earthquakes was also examined to identify the effectiveness of generating anomaly. Both VLF and ULF anomalies were observed for reverse fault type earthquakes occurring under the strong pressure in the crust. Obtained results may indicate the common anomaly source both for VLF and ULF in the lithosphere and are consistent with currently proposed Lithosphere-Atmosphere-Ionosphere (LAI) coupling scenarios during the earthquake preparation period.
High-Density Lipoprotein: From Biological Functions to Clinical Perspectives

High-density lipoprotein (HDL) is a heterogeneous particle composed of apolipoproteins, enzymes, and lipids. Besides transporting cholesterol to the liver, HDL also exerts many protections on anti-oxidation, anti-inflammation, and anti-apoptosis. Initial understandings of HDL came from its protective roles against atherosclerosis and the observation that high plasma HDL cholesterol (HDL-C) levels seemed to decrease cardiovascular disease (CVD) attack. However, those patients either with cholesterol ester transfer protein (CETP) deficiency or tak-ing CETP inhibitors substantially elevated HDL-C levels but did not necessarily decrease CVD risk. Thus, some researchers suggested that quantitative measurements of HDL particle (HDL-P) might be more valuable than traditional HDL-C measurements. What is more bewildering is that HDL from patients with systemic inflammation decreased its protective effects and even became a pro-inflammatory factor. Recently, synthesized HDL and apolipoprotein mimetic peptides showed biological functions similar to native ones. Expectedly, lots of novel measurement methods and therapeutic agents about HDL would be established soon. CE-enriched HDL2. CETP mediates the hetero-transfer of TG and CE between
A CGA-Based Study on Translation Characteristics of Chairman Speeches in Company Annual Reports

This paper aims to analyze the features of chairman speeches and their translations with the critical genre analysis method . By processing the annual reports in Hang Seng Mainland China Property Index2017, we found though chairman speeches contain specific move structures and perspicuous communication purposes, industry environment and self-interest contribution has a profound impact on the wording and rhetorical choices of the chairman speeches, and this can be explained as: the interactivity creates an interdiscursive relationship between business genre community and industry practice. For translatorsand translation teachers, this method maybe a good chance to understand the related industry and select adequate translation and teaching strategies for expected results.