Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigating the effects of exercise on initiation of nitrosomethylurea induced mammary tumorigenesis in young rats

It has been suggested by epidemiological studies that exercise during the college years decreases the risk of breast cancer. The susceptibility of the mammary gland to carcinogenic attack depends on many factors including: 1) developmental stage of the mammary gland; 2) proliferation rate of epithelial cells; and 3) DNA damage. The purpose of t h s thesis was to assess the effects of exercise in young female Sprague Dawley rats on mammary gland development, carcinogen distribution, binding and darnage,and subsequent tumor development. Rats were run on motorized treadmills for four weeks (from twenty one to fifty days of age). Exercise had no effect on mammary gland development, although exercise significantly increased the proliferation rate of the mammary gland epithelial cells. The increased proliferation rate did not affect the amount of Nitrosomethylurea (NMU)induced DNA damage as indicated by the nick translation assay. Increasing the amount of NMU injected ( 25, 37.5 or 50 mgkg) resulted in a dose response in terms of NMU in both the liver and serum. This relationship was apparent at the mammary gland DNA level. However, DNA damage did not increase with increasing doses of NMU. When individual glands were examined, abdominal mammary glands had a lower incorporation of NMU than thoracic or inguinal glands for any concentration of NMU. Of particular interest was the finding that DNA damage was also signficantly lower in the abdominal mammary glands. We tested the effects of exercise prior to carcinogen administration on subsequent tumor development at two doses of NMU. At the higher dose (50 mg/kg) exercise significantly lowered the tumor multiplicity. However at the lower dose (37.5 mglkg) this effect was not seen. At either dose there was no effect on incidence or latency. At a dose of 37.5 mgkg, exercise significantly increased the growth rate and final tumor weights. Due to these differences in growth rates and final tumor weights we assessed the amount of insulin-like growth factor I receptor and estrogen receptor proteins in exercised and sedentary tumors as well as in normal mammary gland tissue. There was a significant increase in the content of both receptors in the tumors relative to the normal tissue. There was a significant difference in receptor content between tumors derived from exercised and sedentary rats when expressed per milligram tissue. This difference was lost when the receptor content was expressed per microgram protein. This thesis suggests that exercise prior to carcinogen administration does effect tumor outcome in a somewhat dose dependent manner. Although exercise increases the proliferation rate of mammary epithelial cells there is no effect on DNA damage or final tumor outcome. This suggests that other mechanisms must compensate for the increased proliferation.
ASH, ACTIVISM AND ACCOUNTING: RESISTING BIG TOBACCO

Design/methodology/approach: This paper presents a longitudinal case study of Ac tion on Smoking and Health UK (ASH) and their use of extern al accounting as part of their campaigns during 1999 2010. The paper develops a typology o f external accounting that integrates the tactics and strategies of activists with external accountin g e tities, visibilities and contents. This paper u ses this typology to analyse ASH’s external accounting a d activism that attends to the problematisation and transformation of tobacco control in the UK.
TRAGEDY IN BHOPAL: ANTENARRATIVE ACCOUNTING

The purpose of this paper is to draw the attention of the accounting researcher to the nature of accounting practiced in the context of non-financial disasters, from a narrative standpoint. Using the Bhopal Gas Tragedy in India in 1984 as a case study, the paper introduces the notion of the antenarrative advocated by Boje (2001) to question the grand narratives published in the 1984 Annual Report by Union Carbide India Limited (UCIL) in the immediate aftermath of the tragedy. The paper analyses the narrative disclosures in the Annual Report, particularly the Directors’ Report, using the antenarrative method and shows how accounting representations function politically and ideologically to paint a picture of safety, stability and responsibility and in the process, communicate a distance between the company and the catastrophe, to shareholders.
Antispermatogenic effects of aqueous ethanolic extract of Hymenocardia acida stem bark in Wistar rats

Oral administration of aqueous ethanolic extract of Hymenocardia acida stem bark for eight weeks caused a significant reduction (P < 0.05) in the weights of testes, epididymides, ventral prostrate, seminal vesicles and vasa differentia compared to the control. The treatment related decreases in sperm motility, count, viability and serum testosterone returned to near normal levels on withdrawal of the extract. The groups that received doses of 100, 200 and 400 mg/kg body weight of the extract showed 40, 0 and 0% fertility, respectively. H. acida stem bark extract adversely affected spermatogenesis in Wistar rats.
New generation capsular endoscopy

The paper discusses the outcomes of the European Project VECTOR FP6 concerning image compression and wireless data transmission systems dedicated to a new generation of capsule endoscopy. The overview of the developed system is given in Section 2. The image compressor algorithm, developed within the project, is presented briefly in the first part of Section 3. Next, a new adaptive entropy encoder proposed for it is discussed in detail. The new encoder, in comparison to the previous one, has much lower memory footprint, as it does not use Huffman tables. Simulation results given in Tab. 1 clearly demonstrate that the new encoder, despite its low implementation complexity, outperform the old one. The developed image compressor algorithm was implemented in a single, 65 nm ultra low-power FPGA. It operates with 24 MHz clock and it is able to process a single image frame in 8.2 ms. Its energy consumption amounts to 0.4 mJ per single compressed frame. In Section 4 a wireless transmission system for wireless capsular endoscopy is presented. In this section an improved demodulator for a wireless receiver is also proposed. Section 5 contains the conclusions.
CD157: From Myeloid Cell Differentiation Marker to Therapeutic Target in Acute Myeloid Leukemia

Human CD157/BST-1 and CD38 are dual receptor-enzymes derived by gene duplication that belong to the ADP ribosyl cyclase gene family. First identified over 30 years ago as Mo5 myeloid differentiation antigen and 10 years later as Bone Marrow Stromal Cell Antigen 1 (BST-1), CD157 proved not to be restricted to the myeloid compartment and to have a diversified functional repertoire ranging from immunity to cancer and metabolism. Despite being a NAD+-metabolizing ectoenzyme anchored to the cell surface through a glycosylphosphatidylinositol moiety, the functional significance of human CD157 as an enzyme remains unclear, while its receptor role emerged from its discovery and has been clearly delineated with the identification of its high affinity binding to fibronectin. The aim of this review is to provide an overview of the immunoregulatory functions of human CD157/BST-1 in physiological and pathological conditions. We then focus on CD157 expression in hematological tumors highlighting its emerging role in the interaction between acute myeloid leukemia and extracellular matrix proteins and its potential utility for monoclonal antibody targeted therapy in this disease.
The therapeutic efficacy of CD133/CD44‐NM‐Gef against lung cancer-initiating cells was assessed by evaluating cell proliferation, tumorsphere formation and detection of CD44+ and CD133+ cells using flow cytometry. The results indicated that CD133/CD44‐NM‐Gef targeted CD133+ and CD44+ lung cancer-ini

Lung cancer is an aggressive type of cancer that is associated with a high mortality rate. Lung cancer-initiating cells are populations of self-renewing cancer cells with pluripotent differentiation ability. Cancers typically originate from multiple phenotypically distinct cancer-initiating cells. CD133 and CD44 are specific markers that maybe used to distinguish lung cancer-initiating cells. The ability to target a variety of subsets of cancer-initiating cells instead of targeting only one population of cancer initiating-cells has the potential to increase the cancer therapeutic efficacy. In the present study, CD133 and CD44 aptamer-conjugated nanomicelles loaded with gefitinib (CD133/CD44‐NM‐Gef) were developed to target CD133+ and CD44+ lung cancer-initiating cells. The therapeutic efficacy of CD133/CD44‐NM‐Gef against lung cancer-initiating cells was assessed by evaluating cell proliferation, tumorsphere formation and detection of CD44+ and CD133+ cells using flow cytometry. The results indicated that CD133/CD44‐NM‐Gef targeted CD133+ and CD44+ lung cancer-initiating cells and exhibited greater therapeutic efficacy against lung cancer‐initiating cells than single-target and non-targeted nanomicelles, suggesting that CD133/CD44‐NM‐Gef represents a promising treatment for lung cancer by specifically targeting lung cancer‐initiating cells. To the best of our knowledge, the present study was the first to report on drug delivery via nanomedicines targeted to multiple populations of cancer-initiating cells using aptamers. As cancer is typically derived from phenotypically distinct cancer-initiating cells, the nanomicelle-based multiple targeting strategy provided is promising for targeting multiple subsets of cancer-initiating cell within a tumor.
LINGUISTIC MOTIVATION FOR STATISTICAL TRANSLATION MODELS

В данной статье рассматриваются проблемы выравнивания параллельных текстов для повышения достоверности перевода. Представлены статистическая и лингвистически-мотивированная модели выравнивания параллельных текстов и перевода методом трансфера. Предлагаемые решения основаны на гибридной грамматике, которая включает лингвистические правила и вероятностные характеристики структур языка. Поскольку сходные значения могут быть представлены различными способами, особенно важны описания синонимии языковых структур. Цель наших исследований — установление соответствий между структурами различных языков на уровне смысла.
Characterization of Robotics Parallel Algorithms and Mapping onto a Reconfigurable SIMD Machine

The kinematics, dynamics, Jacobian, and their cotw_ponding inverse computations are six essential problems in the control of robot manipulators. Efficient parallel algorithms for these computations are discussed and analyzed. Their characteristics are identified and a scheme on the mapping of these algorithms to a reconfigurable parallel architecture is presented. Based on the characteristics including type of parallelism, degree of parallelism, uniformity of the operations, fundamental operations, data dependencies, and communication requirement, it is shown that most of the algorithms for robotic computations possess highly regular properties and some common structures, especially the linear recursive structure. Moreover, they are well-suited to be implemented on a singleinstruction-stream multiple-data-stream (SIMD) computer with reconfigurable interconnection network. The model of a reconfigurable dual network SIMD machine with internal direct feedback is introduced. A systematic procedure to map these computations to the proposed machine is presented. A new scheduling problem for SIMD machines is investigated and a heuristic algorithm, called neighborhood scheduling, that reorders the processing sequence of subtasks to reduce the communication time is described. Mapping results of a benchmark algorithm are illustrated and discussed.
Pathogenesis of the metabolic syndrome and the influence of cannabinoids

The increase in the prevalence of obesity is well recognized and has been seen not only in North America but in Europe and Asia as well. Associated with increased adiposity is increased risk for a variety of diseases, including diabetes and associated comorbidities, cardiovascular disease, and cancer. Thus, it is clear that if the rate of increase of adiposity could be reduced, there could be important consequences regarding public health.
Digital disruption and participation in popular media initiatives in Brazil

This article draws on the results of a doctoral research, defended in June of 2018 at Université catholique de Louvain, in Belgium, and discusses the impact of the appropriation of digital resources in the processes of participation in popular media initiatives. One of the main findings suggests that the tendency of individualization, that is likely in the digital context, imposes important challenges to the participation process, a core feature of popular communication practices. The field research, from 2013 to 2016, included interviews with 55 communicators involved in the management and development of 29 popular media outlets in the states of Paraná, São Paulo, Minas Gerais, Rio Grande do Norte, Ceará and Pará, in Brazil. This particular reflection is mainly based on two case studies on the practices of the Landless Rural Workers Movement (MST – Portuguese Acronym) and the network of community communicators Rede Mocoronga, linked to the Projeto Saúde e Alegria, in the Amazon Region.
Two Sequencing Problems: Equivalence, Optimal Solution, and State-of-the-Art Results

We show that the serial SNPV and the LCFDP are equivalent. The serial SNPV is a special case of the SNPV that tries maximize the expected NPV of a project by sequencing activities that have stochastic durations and cash flows that are incurred at the start of an activity. The LCFDP, on the other hand, minimizes the expected cost of the sequential diagnosis of a set of tests that have known execution costs and failure probabilities.
A Self-adaptive EM-HMRF Image Fusion Algorithm Based on Non-homogeneous Class and Direction

Abstact—Aim at classification-oriented feature-level fusion of remote sensing image, MRF is firstly introduced in this paper to build prior probability models for multiple object classes, and EM-HMRF scheme is introduced into image fusion by taking advantage of the equivalence relation between EM-HMRF and fuzzy classification algorithms. Secondly, focusing on how to select model parameter β with self-adaptive character, a new selecting method is dirived. Then a self-adaptive EM-HMRF fusion algorithm is proposed basing non-homogeneous class and direction, which includes 2 centric and distributed-based fusion schemes. Theory analysis and experiment results show that our proposed algorithms with 2 fusion schemes can not only improve the classification accuracy but also enhance the ability to anti-interference, and they have the different advantages in various fusion systems for different applications, and thus improve the effectiveness of classification basing feature-level fusion of remote sensing image.
A 270-GHz Push-Push Transformer-Based Oscillator Adopting Power Leakage Suppression Technique

A push–push transformer-based oscillator (TBO) adopting a power leakage suppression technique has been proposed. The proposed technique reduces the power loss due to unwanted leakage path without additional DC power consumption, hence improving the output power and DC-to-RF efficiency. The measured output power of the proposed single core oscillator is −4.5 dBm at 270 GHz with 2.1% DC-to-RF efficiency.
Big Data Techniques For Supporting Prediction of Renewable Energy Production

Predicting the output power of renewable energy production plants distributed on a wide territory is a valuable goal, both for marketing and for energy management purposes. Vi-POC (Virtual Power Operating Center) project aims at designing and implementing a prototype able to achieve this goal. Due to the heterogeneity and the high volume of data, it is necessary to exploit suitable Big Data techniques to perform quick and secure access to data, which cannot be obtained with traditional approaches for data management. In this paper, we describe Vi-POC – a distributed system for storing huge amounts of data, gathered from energy production plants and weather prediction services. We use HBase over Hadoop framework on a cluster of commodity servers in order to provide a system that can be used as a basis for running machine learning algorithms. In particular, we perform one-day ahead forecast of PV energy production based on Artificial Neural Networks in two learning settings, that is, structured and non-structured output prediction. Preliminary experimental results confirm the validity of the approach.
Paper#: K125 Do Audit Partners’ Market Shares in an Industry Still Capture Audit Partner Industry Expertise in a Mandatory Audit Partner Rotation Regime? Evidence from the Banking Industry in Taiwan

Prior studies commonly use audit partners’ market s hares in an industry as a proxy for audit partner industry expertise and show that audit partners’ market shares are positively associated with audit quality and audit fee premium . However, these studies are conducted in a voluntary audit partner rotation regime where the l ength of the client-partner relationship is not limited. An audit partner’s market share is determi ned by the market force and competition— expert partners attract more clients and keep the c lients longer. Thus, in a voluntary rotation regime, a partner’s market share naturally reflects his industry expertise. However, in a mandatory partner rotation regime, a partner’s mark et share can be increased or decreased due to rotating into or out of an industry. We hypothesize and find that mandatory audit partner rotation weakens the link between a partner’s market share a nd his industry expertise. While we find that an audit partner’s market share is positively assoc iated with audit quality in the voluntary partner rotation regime in Taiwan in the banking industry, such a positive relation disappears in the mandatory partner rotation regime. We conclude that mandatory audit partner rotation decouples the link between an audit partner’s market share in an industry and his industry expertise and thus reduces the usefulness of market share as a pr oxy for industry expertise. We caution researchers against using audit partners’ market sh are as a proxy for audit partner industry expertise in a mandatory audit partner rotation reg im .
Scripting the profession – Professional role scripting as institutional work carried out by members of voluntary professional associations

Professional roles can be understood as normative templates or scripts for the behaviour of professionals. In this sense, a legitimised and institutionalised role of particular professional groups (e.g. the lawyer), on the one hand, encourages and helps the members of the respective professional group to create a distinctive professional identity (Scott, 1994; Chreim, Williams, & Hinings, 2007). On the other hand, roles help outsiders of a profession to interpret and understand what a particular professional group actually does or aspires to do and how its professional nature can be described (e.g.: “what do lawyers do? ”); at least in an abstract way. Consequently, it can be argued that professional roles, as institutionalised elements, structure most parts of organisational and social life see e.g. Scott, 2008b).
Quantification des débits hépatiques artériel et porte à l'aide des produits de contraste ultrasonores : Application au diagnostic précoce des métastases hépatiques des cancers colorectaux

Objectifs. Quantifier le debit sanguin hepatique au moyen des agents de contraste ultrasonores (PCUS) et evaluer les profils de vascularisation arteriel et portal dans les foies normaux et metastatiques. Materiel et methodes. Vingt huit patients ont ete inclus dans cette etude, huit temoins (MO) et vingt porteurs de metastases hepatiques au cours de l'evolution de cancers colorectaux (M +). Les debits hepatiques de l'artere hepatique et de la veine porte sont apprecies en Doppler energie par la quantification du rehaussement analyse apres injection de PCUS. Le quotient des pentes de rehaussement de l'artere et de la veine permettent d'etablir le Contrast Enhanced Doppler Perfusion Index (CEDPI) sur le meme modele que le Doppler Perfusion Index (DPI). Resultats. Il existe une difference significative entre les CEDPI obtenus dans les foies normaux (0,49 ± 0,07) et les foies metastatiques (0,70 ± 0,12). Conclusion. Cette methode d'evaluation fonctionnelle du debit sanguin hepatique de realisation simple doit permettre de detecter de facon precoce les micro metastases occultes avant les methodes d'imagerie conventionnelle et donc de mieux evaluer la maladie metastatique en particulier dans le bilan d'extension des cancers colorectaux.
Fecal NIRS prediction of dietary protein percentage and in vitro dry matter digestibility in diets ingested by goats in Mediterranean scrubland

A method to elucidate the nutritional value of goats’ diets in ligneous environments is needed. Near infrared spectroscopy (NIRS) can be applied to fecal material to establish statistical relationships between the reflectance of fecal samples in the near infrared region and the diets consumed. We tested fecal NIRS for the prediction of dietary crude protein content (CP) and in vitro dry matter digestibility (DMD) in Damascus goats browsing Mediterranean scrubland dominated by Pistacia lentiscusand Phyllirea latifolia. Two datasets consisting of pairs of feces and dietary data were used; for the first ( n= 151), goats were hand-fed dietary grazing in aset 1, the internal d er. Using s distance s) hen oats r d goats Edited by different ratios of legume hay and concentrate ( n= 60), or combinations of three browse species and concentrate ( n= 91), while for the second ( n= 153), data were collected during 10 observation days with grazing goats. On these days, pairs of information and feces were derived from one observed goat but feces were also sampled from 12 to 15 resident goats the same paddock. Each dataset served for the validation of NIRS equations established with the other. For CP, in dat values ofR2 for calibration were 0.98 (all data) and 0.90 (only browse) and the standard error of cross validation (SECV, validation) was 0.50%. When samples from dataset 2 were used for external validation, R2 varied between 0.55 (all goats) an 0.85 (observed goats) and the standard error of prediction (SEP, external validation) was 2.2 and 1.6% in the same ord dataset 1, we determined that the condition for 95% confidence that two goats ate the same diet was a Mahalanobi (H) of less than 0.5 between their fecal spectra. Using dataset 2, the values of R2 for calibration varied between 0.90 (all goat and 0.92 (only observed goats and residents with H< 0.5 from their fecal spectra) and SECV was approximately 0.50%. W samples from dataset 1 were used for external validation, R2 was 0.47 (calibrations with all goats) and 0.50 (only observed g and resident goats with H< 0.5 from the observed goats), and SEP varied between 0.8 and 1.2% in the same order. Lowe R2 and accuracy were found for in vitro DMD than those for CP. A dataset containing feces and dietary information from observe This paper is part of the special issue entitled: Methodology, nutrition and products quality in grazing sheep and goats, Guest P. Morand-Fehr, H. Ben Salem and T.G. Papachristou. ∗ Corresponding author. fax: +972 3 9669642. E-mail address:vclandau@agri.gov. il (S. Landau). 0921-4488/$ – see front matter © 2005 Elsevier B.V. All rights reserved. doi:10.1016/j.smallrumres. 2005.05. 009 252 S. Landau et al. / Small Ruminant Research 59 (2005) 251–263 seems to be accurate and cost-effective to implement fecal NIRS determination of dietary CP and DM digestibility in grazing goats. © 2005 Elsevier B.V. All rights reserved.