Miracle-dz/UniFAR-FTUs huggingface dataset:
La judicialización de la salud pública en la Argentina

En la labor de asesoria legal de la Obra Social de los Empleados Publicos de Catamarca (OSEP), y en particular en la defensa en juicios de amparo iniciados por afiliados, llamo la atencion e impacto el contenido de las sentencias que condenaban a la obra social a brindar cobertura al ciento por ciento de todo medicamento, tratamiento o prestacion que fuera prescripto o indicado por el medico tratante, al margen de su eficacia, seguridad, costo, razonabilidad del pedido o cualquier otra consideracion. Los avances tecnologicos y cientificos en el campo de la medicina y de la salud se relacionan con el notable incremento en las expectativas y calidad de vida de las personas. A su vez, han influido significativamente en la expansion de los contenidos del derecho a la salud. Esto tambien genero un aumento de la judicializacion de los reclamos. Se propuso analizar aspectos relevantes de las sentencias de cinco causas en contra de dos obras sociales provinciales, cuatro en Catamarca hacia la Obra Social de los Empleados Publicos (OSEP); y la restante, que tomo estado publico a nivel nacional, en Cordoba hacia la Administracion Provincial del Seguro de Salud (APROSS). Ante la generalidad y amplitud de los fallos es preciso determinar si los tribunales tienen dificultad para establecer los contenidos y alcance del derecho a la salud y en su caso desentranar sus causas. Estan acaso los tribunales concibiendo el derecho a la salud como absoluto e ilimitado, anteponiendo el interes particular sobre el colectivo? En este contexto, las onerosas condenas que deben hacer frente las obras sociales provinciales estan impactando en su equilibrio financiero y preocupa a futuro, de seguir esta tendencia, el impacto en el sistema de salud y en particular en el sector publico. Asi las cosas, ? deberian los tribunales medir el impacto que pueden tener sus sentencias? Se propuso tambien analizar si existe una vision o posicion (cultura) particular ante la enfermedad y la muerte que atraviesa todo el sistema de salud, y si esto podria condicionar comportamientos y actitudes de los diferentes actores. Se focalizo en las sentencias de los tribunales, sin pretender desligar de responsabilidad al resto de los actores del sistema. Se necesita un fuerte debate entre todos los actores, a los efectos de poder definir cuales deben ser los contenidos esenciales del derecho a la salud y su alcance, en una discusion que aborde la multiplicidad de dimensiones involucradas en el mismo.
APRENDIZAGEM DE PROFESSORES DE INGLÊS SOBRE USO DE TECNOLOGIA

Este estudo[1] investiga como se deu a aprendizagem de uso de ferramentas tecnologicas por professores em um instituto de linguas especializado no ensino da lingua inglesa. A pesquisa surgiu a partir da verificacao da movimentacao espontânea dentre docentes da instituicao que procuraram aprender com colegas sobre algumas ferramentas que poderiam ser utilizadas para o ensino de ingles. A pesquisa procura ainda identificar o que favoreceu e/ou delimitou essa aprendizagem. A geracao de dados se deu por enquete online via Google Forms e pela gravacao e transcricao de entrevistas nao estruturadas com onze professores participantes da pesquisa. A analise indutiva dos dados permitiu compreender padroes de propagacao de conhecimento entre as participantes do estudo, denominado “efeito polinizador”, favorecidos pelas percepcao de afordances e pela mediacao (social, imitacao e demonstracao). [1] Este artigo esta baseado em dados coletados para realizacao do Mestrado Profissional em Letras Estrangeiras Modernas (MEPLEM), conduzido pela primeira autora, no Programa de Pos-Graduacao em Letras Estrangeiras Modernas, defendida na Universidade Estadual de Londrina (UEL), em 07/05/2018.
Comparing Patient-Reported Medical Problems with the Electronic Health Record Problem List

Electronic health record (EHR) problem lists are extremely important, and yet they are often incomplete and out of date. We compared the EHR problem list to a self-reported problem list obtained via a tablet-administered questionnaire to identify potential synergy. We conducted a retrospective review comparing the EHR problem list to the patients’ self-reported problem list during the year of 2011. To confirm the accuracy of patient self-reports, we also analyzed medication lists, and laboratory results for two selected conditions, hypercholesterolemia and diabetes mellitus. Overall, 1472 patients at the Massachusetts General Hospital (MGH) used the tablet questionnaire. Of these, 843 (57.27%) had no problem reported in the EHR and some problem reported on the tablet (“Tablet Only”); 42 patients (2.85%) had no problem reported on the tablet or in the EHR (“None”); 17 patients (1.15%) had some problem reported in the EHR and no problem reported on the tablet (“LMR Only”); and 570 patients (38.72%) had some problem reported both on the tablet and in the LMR (“Both”). Overall, we studied 59 conditions, of which twelve had enough patients to run Chi Square analysis. Of the 12 conditions analyzed, 10 were significant, and 9 out of 10 conditions favored the tablet-administered questionnaire. Medication lists and laboratory results were reviewed to confirm the presence of the selected conditions. We reviewed the EHR problem list one year after the study was initiated to update the conditions under study. The additional data corroborated 107 additional self-reported conditions in 97 patients. In summary, a self-administered tablet questionnaire is an acceptable method for collecting the medical history. When combined with the EHR problem list, self-reported medical history is optimal for obtaining the most accurate problem list possible.
Mecanismos de las arritmias cardíacas

La circulacion sanguinea es el resultado de los latidos del corazon, que proporciona la fuerza mecanica para bombear la sangre oxigenada hacia, y la sangre desoxigenada lejos de, los tejidos perifericos. Esto depende criticamente de la activacion electrica anterior. Las interrupciones en el patron ordenado de esta onda de excitacion cardiaca pueden conducir a arritmias. La comprension de los mecanismos que subyacen a su generacion y mantenimiento requiere el conocimiento de las contribuciones ionicos para el potencial de accion cardiaco, que se discute en esta revision. Un breve resumen de las diferentes clasificaciones, se proporcionan sistemas de cationes para arritmogenesis, seguido de una discusion detallada de cada mecanismo a su vez, destacando los avances recientes en esta area.
The Effect of Individualized Exercise Parameters Applied to Two Patients Recovering from Implanted Left Ventricular Assist Devices in Korea

Left ventricular assist devices (LVADs) are a treatment option for patients with severe chronic heart failure. These patients are referred to an inpatient cardiac rehabilitation after implantation to improve an aerobic capacity and quality of life (QOL). Several studies have reported that an exercise therapy, which is a component of cardiac rehabilitation, improves exercise capacity and QOL. The LVADs were implanted successfully in a destination therapy in two Korean patients, and these patients were enrolled in the cardiac rehabilitation. After an individualized intervention, they were discharged from improved exercise functional capacity and QOL. This is the first report showing a benefit of the individualized exercise therapy using different parameters after LVADs implantation in Korea.
Mémoire de travail, attention et syntaxe complexe : quelles relations chez les enfants avec trouble développemental du langage ?

Les enfants atteints de troubles developpemental du langage (TDL) rencontrent pour la plupart des difficultes au-dela de la sphere purement langagiere, dans des domaines cognitifs associes comme l’attention et/ou la memoire de travail (MT). Or la litterature met en evidence des liens entre les capacites en memoire de travail, l’attention et les competences langagieres, en particulier au niveau syntaxique, chez les enfants au developpement typique (DT) tout comme chez les enfants avec TDL. Ainsi, nous nous interrogeons dans cette etude sur les effets que pourrait avoir un entrainement specifique et intensif en MT sur les competences en syntaxe complexe et les capacites attentionnelles des enfants avec TDL et au DT. Nous investiguons egalement le role que peut jouer l’attention dans le fonctionnement de la MT, et par consequent dans l’acquisition des competences syntaxiques. Nous avons constitue un echantillon de 22 enfants repartis en deux groupes cognitifs (TDL vs DT). Nous leur avons propose soit un entrainement cible en MT, soit un entrainement controle base sur les competences scolaires. Le meme protocole a ete mis en oeuvre pour les deux types d’entrainement. Les enfants ont suivi un programme d’une duree de huit semaines contenant 24 sessions d’entrainement realisees sur une application i-pad ou un ordinateur, a raison de trois seances par semaine. Avant et apres la phase d’entrainement, nous avons pris des mesures a travers 11 tâches experimentales dans les domaines de l’attention, de la MT et de la syntaxe complexe. Ceci nous a permis d’evaluer les progres realises en pre- versus post-tests dans les domaines etudies. Les resultats mettent en evidence un effet direct de l’entrainement en MT sur les capacites en MT. De plus, un effet de transfert de l’entrainement en MT sur les competences en syntaxe complexe apparait clairement. Enfin, un niveau d’attention selective suffisant semble etre une condition necessaire pour une mise en oeuvre fonctionnelle des mecanismes de MT et par consequent pour le traitement de la syntaxe complexe. En retour, un entrainement en MT permettrait egalement d’augmenter les capacites attentionnelles, en particulier la flexibilite attentionnelle.
Neutrophil gelatinase-associated lipocalin as a marker of acute renal failure in cancer patients treated with cisplatin

Cisplatin is a widely used chemotherapeutic agent in the treatment of solid tumours. Its main side effect, limiting the use of higher doses, is nephrotoxicity manifested by acute kidney injury (AKI). Monitoring of kidney function and AKI detection during the treatment with cisplatin requires a serial measurements of serum creatinine, with estimation of glomerular filtration rate. This method allows the detection of AKI with a 24–48 hour delay, when glomerular filtration rate is significantly decreased. Research conducted in recent years has indicated a group of potential so-called morphological markers of kidney damage that allow earlier detection of AKI, also with subclinical manifestation (without a significant increase in serum creatinine). This is following cardiac surgery and after administration of contrast agents. The best characterised of these markers is neutrophil gelatinase-associated lipocalin (NGAL). It is a protein physiologically existing in the granules of neutrophils, bone marrow, lung, stomach, small and large intestines, pancreas and kidney. Its expression increases in the course of renal epithelial damage. Studies have demonstrated the utility of NGAL assessed in both serum and urine in the diagnosis of ischemic AKI. So far, studies of cancer patients treated with cisplatin did not confirm the usefulness of NGAL determination in serum, but demonstrated that its urine measurements enable earlier diagnosis of AKI than the routine serum creatinine assessment. This paper is a systematic review of these studies.
Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab (T) in patients (pts) with HER2-positive metastatic breast cancer (MBC) which has progressed during treatment with T

1004 Background: T and P bind to different epitopes on the extra cellular domain of HER2. Unlike T, P binds to the dimerization domain and blocks homo- and hetero-dimerization of HER2 with other HER kinase family members. Xenograft models support the hypothesis that the complementary mechanisms of action could result in augmented efficacy when T and P are combined. Methods: Two-stage design, criteria to proceed to the 2nd stage were: ≥ 2 partial responses (PR) or 1 PR and 12 stable disease (SDs) or 13 SDs. Eligibility included: measurable, centrally-tested HER2 positive breast cancer; up to 3 lines of prior chemotherapy plus T (including adjuvant chemotherapy plus T); disease progression during T as most recent treatment for metastatic disease; baseline left ventricular ejection fraction (LVEF) ≥ 55% and no decrease of LVEF to below 50% during prior T treatment. Consenting Pts received T i.v. weekly or every 3 weeks at 2 mg/kg or 6 mg/kg respectively (with re-loading dose if required) plus 420mg fixed dos.
CARTESIAN DUALISM AND PLOTINUS’ PHILOSOPHY OF MIND

: In this paper my intention is to tackle a few issues concerning some interpretations of Plotinus’ “philosophy of mind”. Firstly, I will address the validity of the idea that Plotinus was “the first Cartesian”, advocated by John Dillon and E.K. Emilsson. The idea has been mostly defended on the assumption that Plotinus had anticipated the substance dualism. However, the mind-body dualism evident in Plotinus’ philosophy is in no way identical or similar to the Cartesian, since the basic premises of Plotinus’ metaphysics do not make room for such notions. Another argument is the philosophical use of introspection by both Plotinus and Descartes. However, I would argue that it is exactly the way of employing the method of introspection what introduces a big difference between the two philosophers. Secondly, I will address the idea of Plotinus as a herald of post-Cartesian non-reductionist notions on the mind-body relationship. I argue that Plotinus and his theory of consciousness cannot be interpreted as a variation of the non-reductionst theories, since Plotinus’ “philosophy of mind” in a way transcends the scope of the reductionists vs non-reductionists debates. In fact, non-reductionists share more similarities to Cartesian views, than Plotinus’. Hence comparing Plotinus’ philosophy to post-Cartesian non-reductionism does not differ much from comparing it to Cartesian dualism. The conclusion of the paper is that philosophy of mind can find studying Plotinus’ philosophy very rewarding. However, in paying attention to Plotinus and ancient philosophers in general, we should not miss to pay attention to the scientific and philosophical paradigms of our time that condition the way we approach a problem and anticipate a possible solution to it.
Advantages and Limitations of One-Point Laser Doppler Perfusion Monitoring in Clinical Practice

The laser Doppler technique was first used for studies of blood flow in single vessels of living animals by Riva et at. ' in 1972, who recorded a Doppler shift in the backscattered light when the laser beam was focused on a retinal vessel. Three years later, Stern? presented what is now a classic paper, in which the frequency broadening of light backscattered from the skin was interpreted as that produced by the Doppler shifts which occur when the individual photons interact with the moving blood cells. This phenomenon was utilized by Holloway and Watkins;' who in 1977 presented the first fibre-optics-based portable laser Doppler perfusion monitor. In the beginning of the 1980s Bonner and Nossal" and Nilsson et at. s described how to process the Doppler signal in order to attain an instrument output signal that scales linearly with tissue perfusion, defined as the product of the average speed and concentration of moving blood cells within the scattering volume. Laser Doppler perfusion monitors then became commercially available and successively found a widespread use in experimental medicine as well as in clinical practice. The popularity of laser Doppler perfusion
Ensino da lógica de programação através da gamificação nos anos finais do ensino fundamental II na zona rural no município de Capitão Poço (Pará)

Este artigo descreve um relato de experiência de um projeto de intervenção, no qual se utilizou a gamificação para o ensino de algoritmos. As atividades foram desenvolvidas em uma turma de 8o (oitavo) ano do ensino fundamental de uma escola pública, do município de Capitão Poço-PA. Este apresentou a finalidade de auxiliar no desenvolvimento da lógica de programação e raciocínio lógico, além de propiciar aos alunos adaptação em diferentes ambientes educativos e a compreensão e importância do algoritmo no cotidiano para resolução de problemas. Os resultados obtidos mostraram que a maioria dos alunos conseguiu compreender a proposta e construíram conhecimentos a respeito da computação de forma prática, interativa e dinâmica.
Analyse et conception d'un palonnier à six degrés de liberté

Teaching a prescribed trajectory to a robot manually is possible using current technology. However, to accomplish this, the robot needs to have load sensors. This type of sensor is robust and compact but creates a lag time caused by the time to apply the load on the sensor and the processing time. The main goal of this research project is to develop a displacement sensor. This sensor consists of a miniature passive parallel robot and is designed to be mounted on the wrist of a serial robot. The user will be able to move the parallel robot to control the serial one. The sensor will be used as a dynamic interface when manipulated by the user. Since the effector is circular and mounted around the wrist of the robot, the user will have the impression to directly control the robot. The goal of using this type of sensor is to give the user a more intuitive feeling and a minimum lag time. The prototype can be used to teach a prescribed trajectory to a robot or to move a heavy loads along non-repetitive paths.
Manipulation perçue des marques et résistance, une proposition de profils de consommation

This article aims to identify the different consumer profiles that resist to the perceived manipulation of brands. If there is no consensus on a definition of manipulation, it is established that its perception may give rise to resistance on the part of the consumer. The qualitative study conducted with 14 consumers highlights two strategies, combative or resigned, and brings out four profiles of resistant consumers: the experienced, the reserved, the optimizer and the indifferent.
Guided Letter Writing: A Long Brief Therapy Method Whereby Clients Carry Out Their Own Treatment

This paper describes an innovation in psychotherapy that was initiated by the first author in 1979. It draws upon clients' resources in being able to express themselves in writing rather than relying on the spoken word alone. Terpager found that clients were able to carry out much of the therapeutic work on their own through the process of writing letters. Although he has elaborated and refined his method since it was first developed, it still remains largely unknown. The second author became aware of this work in 1988 and began using it occasionally as well. Tomm eventually agreed to help prepare this brief description of Terpager's method so that it could become more widely available. The paper is not intended to review the literature on writing in therapy, but to outline a single systematic approach.
Likelihood Approaches for Detecting Imprinting and Maternal Effects in Family-Based Association Studies

Genomic imprinting and maternal effect are involved in many complex human diseases but have long been neglected in association studies. In this dissertation, we propose two likelihood approaches for detecting imprinting and maternal effects (LIME) simultaneously in family-based association studies. Since these two effects could cause similar parent-of-origin patterns in binary disease traits, it is important to incorporate both of them into the modeling to avoid lurking effects. Statistical methods that are developed to detect one of them while assuming the absence of the other will report false positives when the assumption is violated. Our first LIME approach (LIME-ped) is designed for general pedigrees with missing genotypes from prospective family-based association studies. LIME-ped formulates the probability of familial genotypes by introducing a novel concept called “conditional mating type” between marry-in founders and their non-founder spouses, and models the penetrance using a logit link. To deal with missing genotypes, LIME-ped enumerates possible unobserved genotypes and sums over the likelihoods of all compatible familial genotypes conditional on observed genotypes. Our simulation study demonstrates that: (1) LIME-ped has the correct type I error rate for testing for imprinting when maternal effect is present, or vice versa; (2) applying LIME-ped to pedigrees fully utilizes the data and achieves higher power than trimming down the pedigrees to nuclear families; (3) “filling in” the unobserved genotypes conditional on ii the genotypes of relatives augments the total information, leading to higher power for LIME-ped than simply excluding individuals with missing genotypes. The second LIME approach (LIME-mix) is designed for case-parent/control-parent triads studies. Since biological fathers are often hard to recruit in family-based studies, we also allow for case-mother/control-mother pairs arising from the triads with missing fathers. The approach is referred to as “LIME-mix”, since the real data is a mixed sample of triads and pairs. We assume multiplicative relative risks due to variant allele effect, genomic imprinting, and maternal effect; and analytically derive the partial likelihood of the family counts with particular genotype combinations. LIME-mix can be applied to either rare or common diseases without restriction on the disease prevalence. Since the partial likelihood does not involve any nuisance parameters about mating types, LIME-mix makes no assumptions on the mating type frequencies, such as allelic exchangeability and mating symmetry, the latter of which is a necessary assumption universally made in many existing imprinting and/or maternal effects detection methods. The robustness of the proposed LIME-mix approach compared to two existing methods is demonstrated via simulation. The LIME approaches are applied to nuclear families, general pedigrees and casecontrol families from the Framingham Heart Study data. Several SNPs that have variant allele, imprinting and/or maternal effects are identified.
Trends in birth spacing

MEASURE DHS assists countries worldwide in the collection and use of data to monitor and evaluate population, health, and nutrition programs. Additional information about the MEASURE DHS project can be obtained by contacting Demographic and The main objectives of the MEASURE DHS project are: • to provide decisionmakers in survey countries with information useful for informed policy choices; • to expand the international population and health database; • to advance survey methodology; and • to develop in participating countries the skills and resources necessary to conduct high-quality demographic and health surveys. The views expressed are those of the authors and do not necessarily reflect the views of USAID or the United States Government.