Miracle-dz/UniFAR-FTUs huggingface dataset:
Sustainable government policy as silver bullet to sustainable business incubation performance In Nigeria

Business incubation has variously been described as a support programme that assist the early-stage entrepreneurs to develop and stay on their own. Furthermore, business incubation programme has been acknowledged as an economic development tool most countries globally adopted. The aim of this study is to examine the contribution of government policy on the relationship between the critical success factors (CSFs) and incubator performance in Nigeria. The questionnaire method of data collection was used to gather 113 usable questionnaires from incubatees in Nigeria’s business incubators. Structural Equation Modeling (SEM) was performed to determine the result using the Partial Least Square (PLS) Software. Government policy as a moderator did not show a significant moderation relationship between the CSF and incubator performance.
Diagnosis and management of polymyalgia rheumatica.

Polymyalgia rheumatica (PMR) is the commonest inflammatory rheumatic disorder affecting older people.1 Patients typically present with bilateral shoulder pain, morning stiffness, raised inflammatory markers, and have a rapid response to low-dose corticosteroids. There is no gold standard diagnostic test and despite being first described in 1888, controversies still exist as to its defining characteristics. PMR carries a lifetime risk of 2.4% for females and 1.7% for males.2 The incidence in the UK has been shown to be 8.42 per 10 000 person years.3 In the UK, the majority of patients are managed exclusively in primary care4 with an average full-time GP seeing five new cases of PMR per year.5 Accurate diagnosis can be challenging even for specialists, but is essential as many serious illnesses can mimic PMR. Guidelines for the diagnosis and management of PMR have recently been published by the British Society of Rheumatologists (BSR) and British Health Professionals in Rheumatology (BHPR). 6 Consider PMR in patients over the age of 50 years with: Subsequent clinical assessment and investigations should …
Proton-Induced Transient Charge Collection in GaAs and InAlSb/InAs-Based FETs

The single-event transient (SET) response of two different n-channel III-V field-effect transistor technologies (GaAs MESFET, InAlSb/InAs HEMT) is measured for the first time for MeV proton irradiation. The characteristics and mechanisms of the proton-induced response of these two technologies are presented and discussed in terms of previous heavy-ion and pulsed-laser measurements. The measurements show that the maximum collected charge, event cross section, pulse amplitude, and full width at half-maximum (FWHM) all increase with increasing proton energy, and decrease as the devices are biased more strongly in depletion. The results are consistent with the presence of charge-enhancement processes that are a consequence of ionization-induced hole accumulation in the substrate/buffer regions of the devices. The InAlSb/InAs HEMT measurements reveal at least an order-of-magnitude lower sensitivity to proton-induced transient generation than the GaAs MESFET in terms of both collected charge and cross section.
Improved convergence results for a modified Levenberg–Marquardt method for nonlinear equations and applications in MPCC

In this paper, we first consider a modified Levenberg–Marquardt method for solving nonlinear equations and show that the method converges superlinearly to a solution of the nonlinear equations under suitable conditions. Then, we reformulate the C-/M-/S-stationarity conditions of mathematical program with complementarity constraints as nonlinear equations so that we may employ the modified Levenberg–Marquardt method to solve these stationarity systems. Preliminary numerical experiments show that the new approach is promising.
Cryptanalysis and Countermeasures on Dynamic-Hash-Table Based Public Auditing for Secure Cloud Storage

Cloud storage can provide outsourcing data services for both organizations and individuals. However, cloud storage still faces many challenges, e.g., public integrity auditing, the support of dynamic data, and low computational audit cost. To solve the problems, a number of techniques have been proposed. Recently, Tian et al. proposed a novel public auditing scheme for secure cloud storage based on a new data structure DHT. The authors claimed that their scheme was proven to be secure. Unfortunately, through our security analysis, we find that the scheme suffers from one attack and one security shortage. The attack is that an adversary can forge the data to destroy the correctness of files without being detected. The shortage of the scheme is that the updating operations for data blocks is vulnerable and easy to be modified. Finally, we give our countermeasures to remedy the security problems.
Fluctuations of inhibitory postsynaptic currents in Purkinje cells from rat cerebellar slices.

1. Paired patch‐clamp recordings were performed in cerebellar slices to study IPSCs evoked by interneurones (stellate and basket cells) in Purkinje cells. 2. IPSCs were first examined while keeping the presynaptic cell in the cell‐attached mode. In some of these experiments IPSCs had a remarkably broad amplitude distribution. Large variabilities were associated with large mean IPSC amplitudes and were preferentially obtained with presynaptic basket cells. Action currents recorded from the presynaptic interneurone in the cell‐attached mode were reproducible indicating that the variability occurs downstream of action potential generation. 3. The variability of IPSC amplitudes was observed independently of the instantaneous firing rate of the presynaptic cell, and could therefore not be ascribed to synaptic fatigue. 4. Highly variable IPSC amplitude were also obtained if the presynaptic interneurone was placed in whole‐cell recording with a potassium‐based intracellular solution. 5. If the recording pipette were filled with Cs+ ions a large increase in the mean of the IPSCs was observed within seconds after establishing the whole‐cell recording. In Cs(+)‐dialysed cells it was possible to modulate the mean IPSC amplitudes by altering the characteristics of the presynaptic stimulation. IPSC amplitudes obtained in response to presynaptic voltage pulses to 0 mV were large and had little scatter. IPSCs obtained in response to pulses near +60 mV, close to the reversal potential of presynaptic Ca2+ currents, had a much lower mean amplitude and also had little scatter. Thus presynaptic application of Cs+ ions both increases the mean amplitude and decreases the variability of the postsynaptic response. 6. To test whether interneurones could be coupled by electrical synapses, paired recordings were performed from neighbouring interneurones. No correlation was found between the firing patterns of such paired recordings, indicating that electrical coupling among presynaptic neurones is not responsible for large IPSC fluctuations as recorded in Purkinje cells. 7. Finally, IPSC fluctuations were investigated in paired recordings from two Purkinje cells. IPSCs corresponding to the activity of common interneurones were identified on the basis of temporal correlation. By plotting the amplitudes of such common IPSCs in one cell against those obtained simultaneously in the other cell, the pattern of IPSCs due to a single presynaptic neurone could be identified. These results show that fluctuations of IPSCs due to the same interneurone in one postsynaptic Purkinje cell are independent of those occurring in another Purkinje cell. 8. The results indicate that the major source of fluctuations is localized within the axonal arborization of presynaptic interneurones. The results with presynaptic Cs+ require that the fluctuations involve the concerted release of several presynaptic vesicles. Two possible mechanisms for such multiquantal events are discussed: fluctuations in presynaptic depolarization, and fluctuations in a regenerative Ca2+ amplification mechanism.
Rapamycin blocks the phosphorylation of 4E‐BP1 and inhibits cap‐dependent initiation of translation.

The immunosuppressant drug rapamycin blocks progression of the cell cycle at the G1 phase in mammalian cells and yeast. Here we show that rapamycin inhibits cap‐dependent, but not cap‐independent, translation in NIH 3T3 cells. Cap‐dependent translation is also specifically reduced in extracts from rapamycin‐treated cells, as determined by in vitro translation experiments. This inhibition is causally related to the dephosphorylation and consequent activation of 4E‐BP1, a protein recently identified as a repressor of the cap‐binding protein, eIF‐4E, function. These effects of rapamycin are specific as FK506, a structural analogue of rapamycin, had no effect on either cap‐dependent translation or 4E‐BP1 phosphorylation. The rapamycin‐FK506 binding protein complex is the effector of the inhibition of 4E‐BP1 phosphorylation as excess of FK506 over rapamycin reversed the rapamycin‐mediated inhibition of 4E‐BP1 phosphorylation. Thus, inactivation of eIF‐4E is, at least in part, responsible for inhibition of cap‐dependent translation in rapamycin‐treated cells. Furthermore, these results suggest that 4E‐BP1 phosphorylation is mediated by the FRAP/TOR signalling pathway.
Sport for tall

Eight new events (handball, basketball, and six rowing events) were introduced for women in the Olympic Games at Montreal in 1976. Of 187 women rowers who competed at Montreal, none was shorter than the mean height (162 cm, 64 in) of women aged 18-24 in the United States. In team events only two out of 250 participants were shorter than the reference mean. Even among the tall, it was the taller participants who won medals. What does the slogan "Sport for All" mean in this context? Moreover, the physical size required of champion rowers and basketball players is not to be found in some Asian, African, and Latin American populations. International contests in many such events therefore seem to be at variance with the first charter of the Olympic Games. An independent reviewing body is urgently needed to examine the merits of man made rules in many sporting contests.
A new three-phase AC-DC-AC multilevel onverter based on cascaded three-leg converters

Static power converters are used for many applications, such as either uninterrupted power supply (UPS) or unified power quality conditioner (UPQC) without isolation transformer. Multilevel converter technologies have been widely recognized as a viable solution to overcome current and voltage limits of low power switching converters in high-power medium-voltage applications. This paper proposes and investigates a new three-phase AC-DC-AC multilevel converter obtained from cascaded three-leg converters. The operating principles, the pulse-width modulation (PWM) techniques and the overall control strategy are presented. The operation with different DC-link voltage values and balancing method are discussed and supported by simulation and experimental results. Simulation results are used to compare the proposed configuration with the conventional solution in terms of harmonic distortion and semiconductor losses. Experimental results demonstrate the feasibility of the studied converter and were obtained by using insulated gate bipolar transistors (IGBTs) with dedicated drives and a digital signal processor (DSP) with appropriated plug-in boards and sensors.
Detecting Software Bad Smells from Software Design Patterns using Machine Learning Algorithms

Design patterns and smells are two approaches that assure design quality. Code smells are symptoms of the design issues which can further hinder the maintenance of the software system. Software Design Patterns represent solutions to various design problems. The code having good design patterns is expected to have less bad smells but their inadequate use can lead to more design smells. Therefore, a code having design patterns can have design smells. This study finding some design pattern and smell pairs which co-exist in the code. This study uses J48 supervised machine learning algorithm to detect the desired relation. The model presented in this paper successfully finds the desired results.
Forced Selection of a Human Immunodeficiency Virus Type 1 Variant That Uses a Non-Self tRNA Primer for Reverse Transcription: Involvement of Viral RNA Sequences and the Reverse Transcriptase Enzyme

ABSTRACT Human immunodeficiency virus type 1 uses the tRNA3Lys molecule as a selective primer for reverse transcription. This primer specificity is imposed by sequence complementarity between the tRNA primer and two motifs in the viral RNA genome: the primer-binding site (PBS) and the primer activation signal (PAS). In addition, there may be specific interactions between the tRNA primer and viral proteins, such as the reverse transcriptase (RT) enzyme. We constructed viruses with mutations in the PAS and PBS that were designed to employ the nonself primer tRNAPro or tRNA1,2Lys. These mutants exhibited a severe replication defect, indicating that additional adaptation of the mutant virus is required to accommodate the new tRNA primer. Multiple independent virus evolution experiments were performed to select for fast-replicating variants. Reversion to the wild-type PBS-lys3 sequence was the most frequent escape route. However, we identified one culture in which the virus gained replication capacity without reversion of the PBS. This revertant virus eventually optimized the PAS motif for interaction with the nonself primer. Interestingly, earlier evolution samples revealed a single amino acid change of an otherwise well-conserved residue in the RNase H domain of the RT enzyme, implicating this domain in selective primer usage. We demonstrate that both the PAS and RT mutations improve the replication capacity of the tRNA1,2Lys-using virus.
ID3 Derived Fuzzy Rules for Predicting the Students Acedemic Performance

This paper presents a technique to use ID3 decision rules to produce fuzzy rules to get the optimize prediction of the students academic performance. In this paper, a the student administrative data for a class is used in order to classify the students final year marks in fuzzy logic prediction . This paper is using the machine learning approach to generate the rules so as to overcome the difficulties in a conventional approach like deriving fuzzy rules base from expert experience. This research provides us with: a way to produce meaningful and simple fuzzy rules; a method to fuzzify ID3-derived rules to deal with many inputs variables; and a de-fuzzification system to get the output in human understandable form. The Id3 tree is generated by the WEKA software and is utilized by the Fuzzy Inference System . A Fuzzy inference system was constructed to give the final crisp output. The ID3 was generated on 300 training data to get the better output. The output of our Fuzzy Student Performance Predictor was then tested on 50 test data to check for the accuracy.
Rola ksiąg rachunkowych w ocenie stanu niewypłacalności przedsiębiorstw w świetle nowych regulacji prawa upadłościowego

Streszczenie: W artykule przeanalizowano związki pomiędzy obrazem przedsiębiorstwa wykreowanym przez jego system rachunkowości a zaistnieniem prawnych przesłanek wszczęcia postępowania upadłościowego. W praktyce gospodarczej i sądowej zaistnienie stanu niewypłacalności dłużnika weryfikuje się najczęściej na podstawie danych z ksiąg rachunkowych. Począwszy od 1 stycznia 2016 r. weszło w życie nowe Prawo upadłościowe, które zasadniczo zmienia pojęcie niewypłacalności przedsiębiorstwa. W artykule omówiono zmiany w systemie prawnym i wskazano na możliwe problemy wynikające z odmiennego rozumienia pojęć takich jak: zobowiązania, zobowiązania przyszłe czy wartość majątku dłużnika na gruncie regulacji Prawa upadłościowego i prawa bilansowego. W pracy wykazano, że mimo zbliżenia się pojęć ekonomicznej utraty płynności i prawnej niewypłacalności, nowe regulacje mogą utrudnić realizację celów, jakie ma pełnić instytucja upadłości we współczesnej gospodarce.
An orphaned Mce‐associated membrane protein of Mycobacterium tuberculosis is a virulence factor that stabilizes Mce transporters

Mycobacterium tuberculosis proteins that are exported out of the bacterial cytoplasm are ideally positioned to be virulence factors; however, the functions of individual exported proteins remain largely unknown. Previous studies identified Rv0199 as an exported membrane protein of unknown function. Here, we characterized the role of Rv0199 in M. tuberculosis virulence using an aerosol model of murine infection. Rv0199 appears to be a member of a Mce‐associated membrane (Mam) protein family leading us to rename it OmamA, for orphaned Mam protein A. Consistent with a role in Mce transport, we showed OmamA is required for cholesterol import, which is a Mce4‐dependent process. We further demonstrated a function for OmamA in stabilizing protein components of the Mce1 transporter complex. These results indicate a function of OmamA in multiple Mce transporters and one that may be analogous to the role of VirB8 in stabilizing Type IV secretion systems, as structural similarities between Mam proteins and VirB8 proteins are predicted by the Phyre 2 program. In this study, we provide functional information about OmamA and shed light on the function of Mam family proteins in Mce transporters.
Tunneling and state specificity in unimolecular reactions

as tunneling, state-specific effects, etc. Also, very seldom has one had much quantitative information about the potential energy surfaces (i.e., barrier heights and other properties of the transition state) for these reactions, so that these parameters have traditionally been adjusted to fit the data, and this can also hide specifics of the dynamics. Both of these situations are beginning to change, however, as molecular beam and a variety of laser methods make it possible to study unimolecular processes under near-ideal, collisionless conditions, where the molecule of interest is excited to an extremely well-defined initial state and then reacts without other competing processes.3"5 These studies require more rigorous dynamical descriptions in order to understand the variety of phenomena seen at this new level of detail. Also, one is beginning to have usefully reliable ab initio quantum chemistry calculations for transitionstate properties of the reacting molecules.6,7 The purpose of this paper is to review the role of tunneling in unimolecular reaction rates. (Tunneling in gas-phase species can also manifest itself as splitt ings of spectral lines—particularly so for symmetric isomerizations—and though not explicitly discussed in this review, this phenomena can also be treated by the theoretical methods described herein. The tunneling splitting in malonaldehyde is an excellent example of this.8'9) Since the state-specific character of unimolecular reactions is intimately involved with tunneling effects, this feature of unimolecular reactions is also discussed. Though I will try to keep the discussion as generally applicable as possible, it will be useful to illustrate a number of points with the specific unimolecular reaction for which the significance of tunneling
Inhibitors and enablers of supply chain management: a study of implementation

Supply chain management was investigated using three objectives: identifying how the management of the supply chain had changed, how new ideas had been implemented and primarily the identification of the inhibitors and enablers of supply chain management. In the 1990s and 2000s research had focused on concepts and approaches. When considering supply chain management it cuts across the whole system including: suppliers, internal company functions, managers, employees, customers information and material flow and services. A large proportion of publications were on materials, matrices, techniques and cost benefits. The literature had little written about management support and employee involvement to engage buy in for supply chain management implementation. There was an overall lack of detail into what actually happened during implementation in the supply chain. Very little was published on the inhibitors of supply chain management.
Delta-Sleep-Inducing Peptide Potentiates Anticonvulsive Activity of Valproate against Metaphit-Provoked Audiogenic Seizure in Rats

The effect of delta-sleep-inducing peptide (DSIP) on the anticonvulsive activity of a nonprotective valproate (VPA) dose in a metaphit model of generalized, reflex audiogenic seizures in adult Wistar rats was studied. The animals that received metaphit (10 mg/kg) were exposed to audiogenic stimulation (100 ± 3 dB, 60 s) at hourly intervals. Metaphit-treated rats displaying seizures in 8 previous tests were i.p. injected with VPA (50 mg/kg) or DSIP (1.0 mg/kg) or their combination. Latency to seizure was behaviorally assessed. The EEGs and power spectra were recorded and analyzed. Neurotoxicity was evaluated by the chimney test. DSIP or VPA alone expressed no significant effect on the latency duration, but their combination significantly prolonged latency to seizure during 6 h after injection, while inducing no significant motor impairment. Neither the applied drugs nor their combination abolished metaphit-provoked EEG epileptiform activity. The results show that DSIP potentiated anticonvulsive effects of a nonprotective VPA dose in a metaphit model of audiogenic seizures without influencing its neurotoxicity.
An empirical analysis of the cost - of - carry model and Istanbul stock exchange futures contract

iii ÖZ . iv DEDICATION . v ACKNOWLEDGMENTS . vi LIST OF TABLES . ix LIST OF FIGURES . x LIST OF ILLUSTRATONS . xi LIST OF ABBREVIATIONS . xii
Differential production in vitro of antigen specific IgG1, IgG3 and IgA: a study in Schistosoma haematobium infected individuals

This study has evaluated the individual control of isotype production and the influence of external signals that can be experimentally provided in vitro, in antibody responses to two different recombinant Schistosoma antigens (Sh28GST and TPx‐1). Peripheral blood mononuclear cells or enriched B cell fractions obtained from S. haematobium infected Senegalese adults were induced to terminal differentiation in vitro. The production of antibody to either antigen was donor‐dependent and for each donor it was antigen‐dependent. Differentiation to IgG1 and IgG3 production, and possibly IgA, specific to these conserved parasite antigens could be regulated differentially in vitro. Exogenous IL‐2 and IL‐10 or IL‐10 and TGF‐β led to the production of specific IgG3 or IgG1 and/or IgA, respectively. This is the first report on such experimentally induced differential regulation of antigen‐specific IgG1 and IgG3. This may have implications in designing protocols for protein based‐vaccinations aiming at eliciting antibody responses of certain protective‐type isotypes.
Data Mining in Long-Term Honeypot Data

Criminal activity in the Internet is becoming more sophisticated. Traditional information security techniques hardly cope with recent trends. Honeypots proved to be a valuable source of threat intelligence. In this work several Honeypots are combined into a Honeynet and observed exploitation attempts. The Honeynet consists of six Honeypots and was operated for 222 days. 12 million exploitation attempts were captured. The captured data is examined and evaluated. Several hypotheses are proposed and analyzed. Dependencies and distribution within the data are identified and quantified. Investigated features are: Temporal and spatial distribution, attacked protocols, involved autonomous systems and the employed dictionaries.