Miracle-dz/UniFAR-FTUs huggingface dataset:
High-Risk Anatomic Variables and Plaque Characteristics in Carotid Artery Stenting

Objectives: To determine anatomic and plaque-related risk factors for patients undergoing carotid artery stenting. Methods: A retrospective review of patients from a prospectively maintained database undergoing carotid artery stenting at our institution between 2001 and 2010 was performed. Preoperative imaging studies (ie, ultrasound, computed tomography angiography, magnetic resonance angiography, and angiograms) were reviewed for specific anatomic criteria and plaque characteristics. Primary outcomes included 30-day stroke or transient ischemic attack (TIA). Secondary outcomes included 30-day death and myocardial infarction (MI). Statistical significance was assumed for P = . 05. Results: Imaging was reviewed for 381 carotid arteries in 375 patients. There were 14 (3.7%) perioperative neurologic events, which included 8 TIA and 6 strokes. Thirty-day mortality and MI were 0.5% and 0.75%, respectively. Degree of internal carotid artery stenosis was associated with primary outcomes (P = .03), and the presence of arch calcification trended toward an increase in primary outcomes (P = .07). However, arch type, ostial involvement, tandem lesions, and plaque calcification did not correlate with primary outcomes. Differences were noted between the sexes, with females having more common carotid artery tortuosity than males (34% vs 27%, P = .04). Females also had a trend toward more plaque calcification and more severe arch calcification than males. These differences did not translate to differences in perioperative neurologic events. Conclusion: Our data suggest that degree of internal carotid artery stenosis and aortic arch calcification may be associated with increased perioperative neurologic risk during carotid stenting, but arch type is not.
Adjuvant therapy after curative resection for gastric cancer: meta-analysis of randomized trials.

PURPOSE An overview is presented of reports published since 1980, in which postoperative adjuvant chemotherapy is compared with surgery alone for patients with gastric cancer. A MEDLINE literature review yielded 123 reports, 14 of which were relevant randomized trials; data from 11 of these trials were (or became) available for analysis of crude mortality odds. These 11 trials included 2,096 patients. METHODS Odds ratios were calculated by comparing the adjuvant treatment arm with the observation-only arm. Those odds ratios that could be considered homogeneous yielded an estimated common odds ratio of 0.88 (95% confidence interval [CI], 0.78 to 1.08), which was slightly, but far from significantly, in support of adjuvant treatment. RESULTS The results confirm the common opinion that the adjuvant chemotherapy regimens prescribed in these trials, although effective in phase II studies, do not improve survival. Furthermore they indicate that postoperative chemotherapy in general offers no additional survival benefit for patients with curatively resected gastric cancer. CONCLUSION In conclusion, at present, postoperative chemotherapy cannot be considered as standard adjuvant treatment. New trials of adjuvant therapy for gastric cancer must include a no-treatment control arm.
Feasibility Investigation of Amorphous Silicon as Release Layer in Temporary Bonding for 3-D Integration and FOWLP Scheme

A reliable temporary bonding scheme with both inorganic amorphous silicon release layer and HD-3007 polyimide based on high 355-nm-wavelength laser absorption coefficient in release layer is proposed and investigated. Effects of laser absorption coefficient and laser ablation path are also studied to develop a high throughput laser ablation process. The bonding scheme can be achieved within the optimized temperature of 210 °C under 1 MPa bonding force. In addition, chemical resistance, mechanical strength with reliability assessment, and thermal stability test for bonded structure are inspected. There is no obvious degradation in electrical characterization after laser ablation, indicating that the temporary bonding scheme has high potential to be used for 3-D integration applications.
Y-Chromosome short tandem repeat (STR) haplotypes in a Campania population sample

Abstract Given the lack of information about Y haplotypes for Campania (southern Italy), we analyzed eight Y short tandem repeats in a sample of males from this region with the aim of establishing a Y-haplotype database that can be used for forensic purposes. The eight Y short tandem repeats were amplified by two PCR multiplex reactions: multiplex A for loci DYS19, DYS385, DYS392 and DYS393, and multiplex B for DYS389 I and II, DYS390, DYS391 and DYS385. The proportion of unique haplotypes was 100% (108 Y-chromosome haplotypes in 108 unrelated males) and the haplotype diversity discrimination index was 0.99. These data reflect the high heterogeneity of male lineage in our population and are similar to those obtained in other regions of southern Italy.
Sustainable operation technologies for the mitigation information network in urban area

Metropolitan areas need to be prepared for predicted epicentral earthquakes. During such a disaster, in order to disseminate mitigation information, such as restoration efforts and evacuation procedures, it is important to provide alternative communication systems. In this paper, we discuss the sustainable operation of a mitigation information network. First, we outline use cases and the requirements for a mitigation information network. Next we propose technologies to ensure continuous operation while retaining transmission quality. Using these methods, the system worked for 72 hours with a throughput of more than 2 Mbps. We checked the setup time during a disaster drill and surveyed persons from the disaster countermeasure offices.
Relations between dark accommodation and psychosomatic symptoms

The ciliary muscle is antagonistically innervated by the autonomic nervous system; near-accommodation is primarily mediated by parasympathetic innervation of the ciliary muscle, while sympathetic innervation produces inhibition of near-accommodation that is relatively small, slow and a function of the concurrent level of parasympathetic innervation. Rapid changes in accommodation are under parasympathetic control, whereas sustained visual tasks involving high levels of cognitive demand involve both parasympathetic and sympathetic control'. In the absence of distinct visual stimuli, e.g. in darkness or in a homogeneous bright field (Ganzfeld), the state of accommodation depends on the baseline or resting level of sympathetic and parasympathetic ciliary muscle innervation, and is referred to as dark accommodation when measurements are made in darkness. Other terms in use are dark focus, tonic accommodation, or resting position of accommodation. Subjects with normal vision vary considerably in their dark accommodation, with an interindividual range of about 0-3 D (i.e. infinity to 0.33 m). The large interindividual variability in dark accommodation is a consequence of differences in the extent of parasympathetic innervation ofthe ciliary muscle in different subjects; the sympathetic innervation is rather similar between subjects'. We were looking for possible effects of the autonomic nervous system on the idiosyncratic long-term position of dark accommodation. Wenger and Ellington^ proposed the concept that each subject can be characterized by his or her general autonomic balance between sympathetic and parasympathetic innervation. This can be estimated by a set of physiological measures (i.e. persistence of red dermographia, salivary output, heart rate, standard palmar skin conductance, volar skin conductance, respiration period, pulse pressure). The score deduced from these measures remains relatively constant over time. Instead of investigating these physiological measures, we compared dark accommodation with several psychological variables that may be expected to be influenced by the autonomic balance of the organism.
Psychiatric Symptomatology as a Predictor of Cyberbullying among University Students

Problem Statement: The internet as online technology has become one of the most popular communication channels among university students worldwide. Young adults and university students have become sophisticated users of technology and often lead the way in adapting new technologies for everyday use. Sometimes their technological savvy can become a gateway, exposing them to a host of sordid activities, including pornography, drugs, violence, and cyberbullying. Although online technologies provide numerous benefits (i.e., learning and teaching activities), online technology also has a potentially ‘dark side,’ as it can be used for harm. The current study focuses on the harmful consequences of one type of misuse of online technology: cyberbullying. Purpose of Study: The purpose of the present study was to investigate the relations between cyberbullying and psychiatric symptoms, and to investigate which symptoms predicted cyberbullying. Methods: This study was cross-sectional and correlational research. A demographic information form, questions about cyberbullying, and a Symptom Check List-90-Revised Form were administered to 695 undergraduate university students (247 males and 448 females). Findings and Results: Data revealed that there are significant differences between “non-bully-victims,” “pure-victims,” “pure-bullies,” and “bullyvictims,” according to the self-reported psychiatric symptom scores. The non-bully-victim group reported significantly less psychiatric symptoms than pure-victims and bully-victims. The path analysis revealed that hostility and psychoticism significantly predicted cyberbullying. Additionally, current cyberbullying could predict the possibility of future cyberbullying. Nearly half of the participants in the current study reported that they pretended (at least one time) to be someone else on the internet or cell phone. Additionally, a significant relation between cyberbullying and anonymity was found. Interestingly, although no gender differences were found in relation to victimization, males engaged in cyberbullying and pretended to be someone else in cyberspace significantly more frequently than females. Additionally, males were more likely than females to endorse that they would engage in cyberbullying in the future.
Development of an Improved Isolation Approach and Simple Sequence Repeat Markers To Characterize Phytophthora capsici Populations in Irrigation Ponds in Southern Georgia

ABSTRACT Phytophthora capsici, the causal agent of Phytophthora blight, is a major concern in vegetable production in Georgia and many other states in the United States. Contamination of irrigation water sources by P. capsici may be an important source of inoculum for the pathogen. A simple method was developed in this study to improve the efficiency of recovering P. capsici from fruits used as baits in irrigation ponds. In contrast to direct isolation on agar plates, infected fruit tissues were used to inoculate stems of pepper seedlings, and the infected pepper stems were used for isolation on agar plates. With isolation through inoculation of pepper stems, the frequency of recovering P. capsici from infected eggplant and pear fruits increased from 13.9% to 77.7% and 8.1% to 53.5%, respectively, compared with direct isolation on agar plates. P. capsici was isolated from seven out of nine irrigation ponds evaluated, with most of the ponds containing both A1 and A2 mating types and a 4:5 ratio of A1 to A2 when isolates from all ponds were calculated. All P. capsici isolates were pathogenic on squash plants, and only a small proportion (8.2%) of the isolates were resistant or intermediately sensitive to mefenoxam. Simple sequence repeats (SSRs) were identified through bioinformatics mining of 55,848 publicly available expressed sequence tags of P. capsici in dbEST GenBank. Thirty-one pairs of SSR primers were designed, and SSR analysis indicated that the 61 P. capsici isolates from irrigation ponds were genetically distinct. Cluster analysis separated the isolates into five genetic clusters with no more than two genetic groups in one pond, indicating relatively low P. capsici genetic diversity in each pond. The isolation method and SSR markers developed for P. capsici in this study could contribute to a more comprehensive understanding of the genetic diversity of this important pathogen.
Retrovirus-induced target cell activation in the early phases of infection: the mouse mammary tumor virus model

Mouse mammary tumor virus (MMTV) infects B lymphocytes and expresses a superantigen on the cell surface after integration of its reverse-transcribed genome. Superantigen-dependent B- and T-cell activation becomes detectable 2 to 3 days after infection. We show here that before this event, B cells undergo a polyclonal activation which does not involve massive proliferation. This first phase of B-cell activation is T cell independent. Moreover, during the first phase of activation, when only a small fraction of B cells is infected by MMTV(SW), viral DNA is detected only in activated B cells. Such a B-cell activation is also seen after injection of murine leukemia virus but not after injection of vaccinia virus, despite the very similar kinetics and intensity of the immune response. Since retroviruses require activated target cells to induce efficient infection, these data suggest that the early polyclonal retrovirus-induced target cell activation might play an important role in the establishment of retroviral infections.
血栓性微血管病鉴别诊断与治疗的进展

DOI:10.3760/cma.j.issn.0253-2727.2015. 03.021 基金项目:国家自然科学基金(30770917、81070395);江苏省科 教兴卫工程-临床医学中心(ZX201102);江苏省临床医学科技专项 (BL2012005) 作者单位:215006 苏州大学附属第一医院,江苏省血液研究 所;卫生部血栓与止血重点实验室 通信作者:王兆钺,Email:zwang11@sina.com Advances in differential diagnosis and treatment of thrombotic microangiopathy Wang Zhaoyue Corresponding author: Wang Zhaoyue, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Key Lab of Thrombosis and Hemostasis of Ministry of Health, Suzhou 215006, China. Email: zwang11@sina.com
Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies

Oxidative stress is implicated in the pathogenesis of many diseases; however, currently used antioxidants have a high toxicity that constrains administration to a narrow window of therapeutic dosage. There is a clear need for more effective and safer antioxidants. Diatomic hydrogen (H2) was proposed as a novel antioxidant that selectively reduces levels of toxic reactive-oxygen species. Recently, many studies have reported that H2 (inhaled or orally ingested, typically as approximately 0.8 mM H2-saturated water), can exert beneficial effects in diverse animal models of ischaemia–reperfusion injury, and inflammatory and neurological disease. In the clinic, oral administration of H2-saturated water is reported to improve lipid and glucose metabolism in subjects with diabetes or impaired glucose tolerance; promising results have also been obtained in reducing inflammation in haemodialysis patients and treating metabolic syndrome. These studies suggest H2 has selective antioxidant properties, and can exert antiapoptotic, anti-inflammatory and antiallergy effects. This review summarizes recent research findings and mechanisms concerning the therapeutic potential of H2.
Postpartum Flatal and Fecal Incontinence Quality-of-Life Scale: A Disease- and Population-Specific Measure

Using various recruiting methods, the authors identified 10 women who suffer from flatal and/or fecal incontinence subsequent to one or more previous vaginal deliveries. Each of these women participated in an individual in-depth 1-hour interview assessing symptom frequency, severity, and impact on quality of life. Participants also completed the Fecal Incontinence Quality-of-Life Scale and evaluated how well this scale captured their experiences. The authors used qualitative analyses to generate themes from the interviews and modified the existing scale, adding new items and themes to capture this population's particular symptom experience. This scale is being evaluated in the context of a surgical clinical trial comparing two techniques for repairing anal sphincter lacerations from delivery.
Experimental demonstration of cascaded transmission and all-optical label swapping for a 1.2Tbit/s O-OFDM 16QAM payload and a 12.5Gb/s OOK label

We demonstrate a network node with two-hop transmission and all-optical label swapping for an O-OFDM 16QAM payload at 1.2Tb/s and an OOK label at 12.5Gb/s. The overall OSNR penalty after label swapping and cascaded transmission is less than 2dB.
Global trend of fundamental frequency in emotional speech

In this study – which is part of an extensive investigation of the prosodic features of emotional speech – global trends of fundamental frequency were examined. The primary goal was to test the use of this parameter to characterize a specific set of emotions (happiness, anger, anxiety, sadness, disgust and boredom). Global F0 trend was measured in the form of the gradient of the linear regression in order to avoid the disadvantages associated with the determination of base and top lines commonly used to examine declination. A secondary goal was to bring a new argument into the discussion of causes for declination and its degree of influence on speech production. Results show a significant steeper downward trend for boredom than for neutral speech and a significant smaller falling global trend for all other emotions than for neutral speech. While the global trend seems to be appropriate especially for the description of boredom and sadness and to a slightly lesser extent also for anxiety and disgust, it is almost meaningless for the emotions happiness and anger. In happy and angry utterances the pitch accents are strong enough to hide the global downward trend completely. The results for each emotion are discussed in detail with respect to specific physiological constraints, as well as auditory impression and other prosodic features typical for these emotions.
Mutations of keratinocyte transglutaminase in lamellar ichthyosis

Lamellar ichthyosis is a severe congenital skin disorder characterized by generalized large scales and variable redness. Affected individuals in three families exhibited drastically reduced keratinocyte transglutaminase (TGK) activity. In two of these families, expression of TGK transcripts was diminished or abnormal and no TGK protein was detected. Homozygous or compound heterozygous mutations of the TGK gene were identified in all families. These data suggest that defects in TGK cause lamellar ichthyosis and that intact cross-linkage of cornified cell envelopes is required for epidermal tissue homeostasis.
ULTRA–WIDE-FIELD ANGIOGRAPHY IMPROVES THE DETECTION AND CLASSIFICATION OF DIABETIC RETINOPATHY

Purpose: To evaluate patients with diabetic retinopathy using ultra–wide-field fluorescein angiography and to compare the visualized retinal pathology with that seen on an overly of conventional 7 standard field (7SF) imaging. Methods: Two hundred and eighteen eyes of 118 diabetic patients who underwent diagnostic fluorescein angiography using the Optos Optomap Panoramic 200A imaging system were included. The visualized area of the retina, retinal nonperfusion, retinal neovascularization, and panretinal photocoagulation were quantified by two independent masked graders. The respective areas identified on the ultra–wide-field fluorescein angiography image were compared with an overly of a modified 7SF image as outlined in the Early Treatment Diabetic Retinopathy Study. Results: Ultra–wide-field fluorescein angiograms imaging, on average, demonstrated 3.2 times more total retinal surface area than 7SF. When compared with 7SF, ultra–wide-field fluorescein angiography showed 3.9 times more nonperfusion (P < 0.001), 1.9 times more neovascularization (P = 0.036), and 3.8 times more panretinal photocoagulation (P < 0.001). In 22 eyes (10%), ultra–wide-field fluorescein angiography demonstrated retinal pathology (including nonperfusion and neovascularization) not evident in an 7SF overly. Conclusion: Compared with conventional 7SF imaging, ultra–wide-field fluorescein angiography reveals significantly more retinal vascular pathology in patients with diabetic retinopathy. Improved retinal visualization may alter the classification of diabetic retinopathy and may therefore influence follow-up and treatment of these patients.
In Folio Respiratory Fluxomics Revealed by 13C Isotopic Labeling and H/D Isotope Effects Highlight the Noncyclic Nature of the Tricarboxylic Acid “Cycle” in Illuminated Leaves1[W]

While the possible importance of the tricarboxylic acid (TCA) cycle reactions for leaf photosynthesis operation has been recognized, many uncertainties remain on whether TCA cycle biochemistry is similar in the light compared with the dark. It is widely accepted that leaf day respiration and the metabolic commitment to TCA decarboxylation are down-regulated in illuminated leaves. However, the metabolic basis (i.e. the limiting steps involved in such a down-regulation) is not well known. Here, we investigated the in vivo metabolic fluxes of individual reactions of the TCA cycle by developing two isotopic methods, 13C tracing and fluxomics and the use of H/D isotope effects, with Xanthium strumarium leaves. We provide evidence that the TCA “cycle” does not work in the forward direction like a proper cycle but, rather, operates in both the reverse and forward directions to produce fumarate and glutamate, respectively. Such a functional division of the cycle plausibly reflects the compromise between two contrasted forces: (1) the feedback inhibition by NADH and ATP on TCA enzymes in the light, and (2) the need to provide pH-buffering organic acids and carbon skeletons for nitrate absorption and assimilation.
Research Note - Why Following Friends Can Hurt You: An Exploratory Investigation of the Effects of Envy on Social Networking Sites among College-Age Users

Research findings on how participation in social networking sites SNSs affects users' subjective well-being are equivocal. Some studies suggest a positive impact of SNSs on users' life satisfaction and mood, whereas others report undesirable consequences such as depressive symptoms and anxiety. However, whereas the factors behind the positive effects have received significant scholarly attention, little is known about the mechanisms that underlie the unfavorable consequences. To fill this gap, this study uses social comparison theory and the responses of 1,193 college-age Facebook users to investigate the role of envy in the SNS context as a potential contributor to those undesirable outcomes. Arising in response to social information consumption, envy is shown to be associated with reduced cognitive and affective well-being as well as increased reactive self-enhancement. These preliminary findings contribute to the growing body of information systems research investigating the dysfunctional consequences of information technology adoption in general and social media participation in particular.