Miracle-dz/UniFAR-FTUs huggingface dataset:
Data Mining in Education

Data mining techniques are used to extract useful knowledge from raw data. The extracted knowledge is valuable and significantly affects the decision maker. Educational data mining (EDM) is a method for extracting useful information that could potentially affect an organization. The increase of technology use in educational systems has led to the storage of large amounts of student data, which makes it important to use EDM to improve teaching and learning processes. EDM is useful in many different areas including identifying at-risk students, identifying priority learning needs for different groups of students, increasing graduation rates, effectively assessing institutional performance, maximizing campus resources, and optimizing subject curriculum renewal. This paper surveys the relevant studies in the EDM field and includes the data and methodologies used in those studies
Protein III: structure, function, and genetics

Protein III (PIII) was originally described by McDade and Johnston (14). In their studies of the gonococcal outer membrane, they observed that all gonococcal strains contained a similar protein whose apparent molecular weight in sodium dodecyl sulfate-polyacrylamide gel electrophoresis increased upon treatment with a reducing agent. Furthermore, they and others (14, 17) provided evidence, using bifunctional cross-linking reagents, that PIII was closely associated with the protein I (PI) porin within the gonococcal outer membrane. It was further shown that PIII was structurally and immunologically conserved among several strains of gonococci (11, 12). In studies in which several proteolytic enzymes were used to investigate the surface orientation of gonococcal outer membrane proteins, PIII was found to be resistant to protease treatment (2). However, Shafer and Morse, using lysosomal cathepsin G, showed that PIII in gonococcal outer membranes could be cleaved by this enzyme (20). In addition, the rate at which PIII was degraded by cathepsin G could be correlated to the lipooligosaccharide expressed by a particular strain of gonococcus; i.e., the PIII associated with low-molecular-weight lipooligosaccharide was cleaved more rapidly than was the PIII associated with a higher-molecular-weight lipooligosaccharide. Surface-labeling experiments and the ability of PIII to react in vivo with a monoclonal antibody also indicated that PIII had surface-exposed domains (22). Our interest was piqued by several unanswered questions. We wanted to know (i) how this highly conserved, surface-exposed protein could exist in an organism that expended a great deal of its genome and energy in antigenic variation; (ii) how, if at all, PIII affected the functions of PI; and (iii) how PIII could be eliminated as a contaminant in preparations of PI.
Shooting the moving target: machine learning in cybersecurity

We introduce a platform used to productionize machine learning models for detecting cyberthreats. To keep up with a diverse and ever evolving threat landscape, it is of paramount importance to seamlessly iterate over the two pillars of machine learning: data and models. To satisfy this requirement, the introduced platform is modular, extensible, and automates the continuous improvement of the detection models. The platform counts more than 1000 successful model deployments at over 30 production environments.
Commentary Net Neutrality: Telecom Policy and the Public Interest

What is net neutrality? The debate about the shape of the Internet is being held behind closed doors, led by government and industry with little pub- lic input. This article examines net neutrality and the stakeholders in this emerg- ing national debate. The authors discuss the legislative and policy implications, while at the same time exploring alternative models for achieving broadly acces- sible, affordable high-speed Internet access. Resume : Qu'est-ce que ca veux dire la « net neutrality »? Au moment, le debat sur le futur de l'Internet est controle par le gouvernement et les interets du com- merce, sans des consultations publiques. Cet article examine la neutralite de l'Internet et les participants divers dans cette discussion emergente. Les auteurs discutent le des consequences legislatives et politiques, pendant qu'ils explorent des modeles alternatifs pour atteindre l'acces a l'Internet universele, haute- vitesse, et abordable.
Genome wide decrease of DNA replication eye density at the midblastula transition of Xenopus laevis

ABSTRACT During the first rapid divisions of early development in many species, the DNA:cytoplasm ratio increases until the midblastula transition (MBT) when transcription resumes and cell cycles lengthen. S phase is very rapid in early embryos, about 20–30 times faster than in differentiated cells. Using a combination of DNA fiber studies and a Xenopus laevis embryonic in vitro replication system, we show that S phase slows down shortly after the MBT owing to a genome wide decrease of replication eye density. Increasing the dNTP pool did not accelerate S phase or increase replication eye density implying that dNTPs are not rate limiting for DNA replication at the Xenopus MBT. Increasing the ratio of DNA:cytoplasm in egg extracts faithfully recapitulates changes in the spatial replication program in embryos, supporting the hypothesis that titration of soluble limiting factors could explain the observed changes in the DNA replication program at the MBT in Xenopus laevis.
The Use of Health Information Technology in Saudi Primary Healthcare Centers

The purpose of this exploratory study is to provide an overview of health information technologies (HITs) used in primary healthcare centers (PHCC) in the Kingdom of Saudi Arabia. Data collection methods included key stakeholder interviews and an academic search using a variety of keyword terms. Evidence shows that the use of health information technologies in Saudi PHCCs is growing although is still in its early stages. Despite the numerous steps undertaken in upgrading and operating the Kingdom electronic health information system (EHIS) as a consequence of the national strategic roadmap of alignment with the electronic health (e-Health) Strategic objectives, yet there is still a mounting need to address realistic approaches in implementing e-health services in Saudi PHCCs. Particularly, tackling barriers that hinder the use of EHIS in PHCCs.
Sukuk pricing dynamics - factors influencing yield curve of the Malaysian Sukuk

The greater financial integration particularly over the past decade has led to more synchronized movements of financial markets across the globe. As the domestic debt capital market, particularly the Malaysian Government Securities (MGS) and Government Investment Issue (GII or Government Sukuk), shariah compliant Malaysian sovereign papers deepen, the movements of the domestic yield curve are expected to be increasingly influenced by movements in foreign bond yields as both domestic and foreign investors respond to global developments and sentiments. Based on standard time series techniques, our findings tend to indicate that GII as well as MGS are weakly endogenous subject to changes in US Treasury which are most probably transmitted through changing their investment preference and expectation of liquidity and risk premium that they are willing to pay by holding local currency bonds and sukuk. This may create shifting in yield curve and significant capital outflows or inflows that may destabilize financial condition that requires policy changes. Finally, the findings also reaffirmed that the sukuk is still priced based on the conventional way of pricing bonds.
A cultural competency course for pharmacy students.

OBJECTIVE To design, implement, and evaluate a course on health promotion and literacy. DESIGN Course objectives such as the development of cultural competency skills, awareness of personal biases, and appreciation of differences in health beliefs among sociocultural groups were addressed using a team-based learning instructional strategy. Student learning outcomes were enhanced using readiness assessment tests (RATs), group presentations, portfolio reflections, and panel discussions. ASSESSMENT Comparing precourse and postcourse Inventory for Assessing the Process of Cultural Competence among Healthcare Professionals (IAPCC-R) scores and portfolio responses indicated enhanced progress toward cultural competency. The Student Evaluation of Teaching (SET) provided suggestions for course enhancements. CONCLUSIONS Evidence supporting enhanced cultural competency after completing the course affirms its value as we prepare pharmacy students to provide patient-centered care in a culturally diverse world.
TRPV 4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells

*Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Parc Recerca Biomèdica de Barcelona, Carrer Doctor Aiguader 88, 08003 Barcelona, Spain; †Center for Translational Neuroscience, Duke University Medical Center, Durham, NC 27708; and ‡Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655
Hydroxyproline-Rich Glycoproteins as Markers of Temperature Stress in the Leaves of Brachypodium distachyon

Plants frequently encounter diverse abiotic stresses, one of which is environmental thermal stress. To cope with these stresses, plants have developed a range of mechanisms, including altering the cell wall architecture, which is facilitated by the arabinogalactan proteins (AGP) and extensins (EXT). In order to characterise the localisation of the epitopes of the AGP and EXT, which are induced by the stress connected with a low (4 °C) or a high (40 °C) temperature, in the leaves of Brachypodium distachyon, we performed immunohistochemical analyses using the antibodies that bind to selected AGP (JIM8, JIM13, JIM16, LM2 and MAC207), pectin/AGP (LM6) as well as EXT (JIM11, JIM12 and JIM20). The analyses of the epitopes of the AGP indicated their presence in the phloem and in the inner bundle sheath (JIM8, JIM13, JIM16 and LM2). The JIM16 epitope was less abundant in the leaves from the low or high temperature compared to the control leaves. The LM2 epitope was more abundant in the leaves that had been subjected to the high temperatures. In the case of JIM13 and MAC207, no changes were observed at the different temperatures. The epitopes of the EXT were primarily observed in the mesophyll and xylem cells of the major vascular bundle (JIM11, JIM12 and JIM20) and no correlation was observed between the presence of the epitopes and the temperature stress. We also analysed changes in the level of transcript accumulation of some of the genes encoding EXT, EXT-like receptor kinases and AGP in the response to the temperature stress. In both cases, although we observed the upregulation of the genes encoding AGP in stressed plants, the changes were more pronounced at the high temperature. Similar changes were observed in the expression profiles of the EXT and EXT-like receptor kinase genes. Our findings may be relevant for genetic engineering of plants with increased resistance to the temperature stress.
Oral Pathology unmasking Gastrointestinal Disease

Abstract Different ggastrointestinal disorders, such as Gastroesophageal Reflux Disease (GERD), Celiac Disease (CD) and Cohn’s disease, may manifest with alterations of the oral cavity but are often under and misdiagnosed both by physicians and dentists. GERD can cause dental erosions, which are the main oral manifestation of this disease, or other multiple affections involving both hard and soft tissues such as burning mouth, aphtous oral ulcers, erythema of soft palate and uvula, stomatitis, epithelial atrophy, increased fibroblast number in chorion, xerostomia and drooling. CD may be responsible of recurrent aphthous stomatitis (RAS), dental enamel defects, delayed eruption of teeth, atrophic glossitis and angular chelitis. Crohn's disease can occur with several oral manifestations like indurated tag-like lesions, clobbestoning, mucogingivitis or, less specifically, with RAS, angular cheilitis, reduced salivation, halitosis, dental caries and periodontal involvement, candidiasis, odynophagia, minor salivary gland enlargement, perioral erythema with scaling, recurrent buccal abscesses, glossitis, mucosal discoloration, lichen planus, and metallic dysgeusia. A prompt detection of the oral signs of these systemic diseases allows an early diagnosis and treatment and could prevent related long-term complications.
A Diabetes Management Mentor Program: Outcomes of a Clinical Nurse Specialist Initiative to Empower Staff Nurses

Purpose: The purpose of this project was to enhance the knowledge of the bedside nurse in diabetes management. A forum for ongoing support and exploration of clinical problems, along with the distribution of educational tools were the components of this program. Background: Diabetes accounts for 30% of patients admitted to the hospital. It has become more challenging to manage as the treatment choices have increased. There are a number of researchers who have identified nurse and physician knowledge of diabetes management principles as suboptimal. Description of the Innovation: Staff nurses are educated for a role as a Diabetes Management Mentor and are expected to educate/dialogue with peers monthly, model advocacy and diabetes patient education skills, facilitate referrals for diabetes education, and direct staff to resources for diabetes management. Outcomes: Diabetes Management Mentors feel more confident in their knowledge of diabetes and their ability to resolve clinical issues as they arise. Conclusion: The Diabetes Management Mentor role is another avenue for nurses to refine their clinical knowledge base and acquire skills to share with colleagues while remaining at the bedside. Implications: The clinical nurse specialist is expertly prepared to foster the professional development of bedside nurses while simultaneously making a positive impact on disease management. Opportunity for future investigation includes efficacy of teaching tools on diabetes mastery, the effect of clinical nurse specialist mentoring on a select group of bedside nurses, and the Diabetes Management Mentor’s impact on prevention of near-miss events.
[Topographic classification of glaucomatous visual fields].

PURPOSE To propose a classification of glaucoma visual fields based on affected ganglion cells axons on their way through the optic nerve head. MATERIAL AND METHOD 255 Octopus 1-2-3 visual fields from glaucoma patients and glaucoma suspected patients were analyzed. Determination coefficients (r(2)) between the 10 points closest to the blind spot and the 73 reminding ones were calculated by linear regression. RESULTS Significant correlation was found (r(2)>0.33) with very distant points sensitivity related to the ones closer to the optic disc due to the fibers path. Seven areas could be defined by this method: three of them are not affected or latterly affected by the disease: S1 and I1 corresponding to the upper and lower papillo-macular bundle and T, located on the temporal aspect of the blind spot. Areas S2 and L2 correspond to the nasal and para-central upper and lower sensitivities. Areas S3 and I3 are in the border of upper and lower nasal fields where axons enter the optic disc at the apical portion. CONCLUSIONS There is a relationship between the anatomical arrangement of ganglion cells axons on their way to the optic nerve and topography of glaucoma defects which may justify this proposed classification.
Immune System and DNA Repair Defects in Ovarian Cancer: Implications for Locoregional Approaches

In the last few years, substantial progress has been made in the treatment of ovarian cancer, with increased knowledge about the biology of the disease. Ovarian cancer is a neoplasm strongly linked to defects in DNA repair mechanisms, where deficiency in the homologous recombination (HR) system results in a better response of ovarian cancers to therapy, whether platinum-based chemotherapy, anthracyclines, or poly (ADP-ribose) polymerase (PARP) inhibitors. More recently, it has been demonstrated that different ovarian cancer histotypes may have different immunogenicity. Interestingly, defects in HR systems are associated more frequently with higher tumor infiltrating lymphocytes, providing a rationale for developing combination therapy with immune-modulating agents and PARP inhibitors. Again, locoregional therapies combining heat shock and chemotherapy delivery have been shown to induce an anticancer immune response in vitro. Thus, the potential for locoregional therapeutic approaches that may impact the immune system, perhaps in combination with immune-modulating agents or PARP inhibitors, needs to be further explored. With this premise, we reviewed the main biological and clinical data demonstrating a strict interplay between the immune system, DNA repair mechanisms, and intraperitoneal therapies in ovarian cancer, with a focus on potential future therapeutic implications.
In vitro Analyses of the Dysregulated R206H ALK2 Kinase-FKBP12 Interaction Associated with Heterotopic Ossification in FOP

A single recurrent mutation in the regulatory subdomain of a bone morphogenetic protein type I receptor kinase has been linked to heterotopic ossification in classic fibrodysplasia ossificans progressiva (FOP). As a result of a substitution at 1 residue by only 1 other side chain (Arg206His) in just 1 of the 4 type I BMP receptors (ALK2/ACVR1), soft connective tissues progressively metamorphose through an endochondral process into cartilage that is replaced by bone. The substitution of arginine for histidine, also a basic residue yet with the singular property of ionization/protonation over the physiological pH range, led to the hypothesis of an aberrant, pH-sensitive switch mechanism for the ligand-independent activation of BMP signaling through the mutant receptor kinase in patients presenting with classic FOP. To test a potential aspect of the putative pH-dependent mechanism, i.e. loss of autoinhibition of the kinase mediated by the inhibitory protein FKBP12, in vitrointeraction analyses with purified wild-type and R206H ALK2 kinase and FKBP12 proteins were performed. Interactions between the kinases and inhibitory proteins were analyzed qualitatively and quantitatively by native gel electrophoresis and HPLC size exclusion chromatography and with an optical biosensor (Octet; ForteBio). Binding of inhibitory protein by the R206H mutant was diminished 3-fold relative to the wild type kinase at a physiological pH, yet below this value (<∼7.5) pronounced nonspecific interactions, particularly with the mutant, prevented comparative evaluations. In conclusion, substitution with histidine leads to partial loss of inhibition of the mutant type I receptor through diminished binding of FKBP12, which may act as a gradient reader in morphogenetic contexts.
Comparison between antibiotic therapy of Brucellosis with and without vitamin A

Background: Brucellosis is one of the endemic diseases in our country and it can be in the types of acute, sub-acute or chronic. It estimates that about 20% of Brucellosis may change from acute to chronic. Because cell mediated immunity (CMI) is the main defense of body against Brucella species, it seems that some degree of Immunologic disorders existed in the patients with chronic form of diseases and some supplements such as Vitamin A (Vit A) as an immunomodulator can stimulate CMI and may decrease the rate of chronicity. Materials and Methods: In a single-blind randomized clinical trial 120 patients with the clinical and serological diagnosed Brucellosis were randomized. A total of 60 patients received streptomycin and Doxycycline as standard therapy for 6 weeks and others in addition to this Regimen received Vit A for about 4 weeks. Results: In the case group, only 1 case (1.6%) relapsed and in the control group 8 (13.5%) with significant difference (P < 0.005) between two groups. Morbidity of disease was different between two groups. Conclusion: Vit A therapy in the patients with Brucellosis with may reduce the disease morbidity and rate of chronicity.
Margin Sample Mining Loss: A Deep Learning Based Method for Person Re-identification

Person re-identification (ReID) is an important task in computer vision. Recently, deep learning with a metric learning loss has become a common framework for ReID. In this paper, we also propose a new metric learning loss with hard sample mining called margin smaple mining loss (MSML) which can achieve better accuracy compared with other metric learning losses, such as triplet loss. In experi- ments, our proposed methods outperforms most of the state-of-the-art algorithms on Market1501, MARS, CUHK03 and CUHK-SYSU.
Ustekinumab is effective in biological refractory Crohn’s disease patients–regardless of approval study selection criteria

Background/Aims Ustekinumab is effective in active Crohn’s disease. In a retrospective study, we assessed the clinical outcome in nonresponders to anti-tumor necrosis factor therapy, and/or conventional therapy and/or the α4β7-integrin inhibitor vedolizumab. As approval study populations do not always reflect the average “real world” patient cohort, we assessed weather patients who would not have qualified for approval studies show similar outcomes. Methods Forty-one patients with mild to severe active Crohn’s disease were treated with ustekinumab (intravenous 6 mg per kg/body weight) followed by subcutaneous ustekinumab (90 mg) at week 8. Depending on the clinical response maintenance therapy was chosen every 8 or 12 weeks. Clinical response was defined by Crohn’s Disease Activity Index (CDAI) decline, decline of stool frequency or clinical improvement. Inclusion criteria for approval studies were assessed. Results The 58.5% (24/41) showed clinical response to ustekinumab. The 58.3% of this group (14/24) achieved clinical remission. Clinical response correlated significantly with drop of stool frequency and improvement of CDAI score. The 39 out of 41 patients had no side effects and we observed no serious infections. About a third of our patients would not have met ustekinumab approval study criteria. However, patients who did not meet study criteria showed clinical improvement numerically in the same range compared to patients who would have qualified for approval studies. Conclusions Ustekinumab is effective, safe and well tolerated in a highly therapy refractory patient cohort. Even though a reasonable number of patients did not meet ustekinumab approval study criteria, approval study results seem to be representative to the overall patient cohort.
What are the Wage and Employment Consequences of Leveraged Buyouts, Private Equity and Acquisitions in the UK?

This paper provides the first comparative examination of the consequences of leveraged buyouts (LBOs) and traditional corporate acquisitions on employment and wages using a uniquely constructed panel data set covering the period 1996-2006. Employing propensity score matching combined with difference-in-differences analysis, the key findings are: (1) related and unrelated acquisitions have employment consequences of a similar magnitude, (2) related and unrelated acquisitions have the largest negative impact on employment followed by non-private equity backed LBOs, (3) acquisitions in the same industry cause an increase in wages, and (4) private equity backed LBOs have no significant impact on either employment or wages.