Miracle-dz/UniFAR-FTUs huggingface dataset:
SLEEP DISORDER IN THE PATIENTS WITH PARKINSON'S DISEASE–RELATIONS WITH CLINICAL FACTORS

Introduction: Sleep disorders are widely seen in Parkinson’s disease. This study was planned to evaluate sleep disorder and clinical symptoms related to Parkinson’s disease. Materials and Method: Seventy patients (30 female, 40 male) and a control group of 40 healthy subjects (20 female and 20 male) were included in this study. “Hoehn-Yahr” scale for staging the disease and the “Parkinson’s Disease Sleep Score (PDSS)” scale for the assessment of sleep disorders were used. Results: The average age of patient group is (67.28±9.32), was not different from the control group (64.4±9.42). PDSS was significantly lower in patients (87.23±33.71) than controls (140.32±11.15) (p<0.0001). There was not significant difference for TUS between patients who were treated with dopamine agonists. There was not significant difference in the PDSS-TUS for diskinesia (p=0.079). There was a significant difference for PDSS-TUS for postural disorder and bradymimia (p=0.023 and p=0.005 respectively). In patients with advanced stage Parkinson’s disease, PDSS was found significantly higher (59.31±26.23) than in mild stage patients (95.66±31.23) (p<0.0001). Conclusion: It is neccessary to take a detailed history of sleep and to detect the sleep disorder in patients with advanced stage of Parkinson’s disease. Some symptoms as bradymimia and postural disorders can be warning sign for sleep disorder.
The Action of Bcl-2 Apoptotic Family Proteins and Caspases in Mediating Follicle Atresia in Adult Mouse

Among follicles present on the surface of the ovary only a small part reach ovulation, the majority entering atresia, which is an apoptotic process regulated hormonally in general. Apoptosis (from greek: apo = from, ptosis = falling) - is a normal physiological process, genetically programmed cell death, which carries energy consumption by activating a program of internal suicide. This occurs at each stage of follicular development and is accompanied by a significant reduction in the number of follicles present at birth. Development stage-dependent mechanisms coordinate the evolution of follicles, leading to ovulation of a very small number of them. At follicular level apoptosis involves many morphological and biochemical processes that are based on pro-and anti-apoptotic members of Bcl-2 family of proteins (located on mitochondrial outer membrane) and caspases. These changes aim internucleosomal DNA fragmentation, cell retraction followed by its wrinkling, cytoskeleton disruption, preservation of cytoplasmic organelles structure and function, loss of intercellular ties with the reduced expression of conexine 43 (key protein of communication junctions between granulose cells), progressive fragmentation of nucleus and cytoplasm, and finally the appearance of apoptotic bodies, and their inclusion by phagocytes, without the involvement of any inflammatory response.
An Examination of the Age of Substance Use Onset and Adult Severity of Use Among Offenders Entering Treatment

Early onset of substance use has demonstrated a robust relationship with later severity of use, yet this relationship has been less examined in criminal justice contexts or examined differentially by gender. The present study utilized secondary data from a sample of offenders in one small Midwestern state entering corrections-based substance abuse treatment in prison, jail, or community settings to address these gaps in the literature. Findings indicated that age of regular cigarette use did not uniquely affect severity of illicit drug use in adulthood, defined as the frequency of use or endorsement of substance use disorder criteria. In comparison, ages of onset for alcohol and illicit drug use were significantly associated with multiple severity variables examined. Gender was not found to moderate these relationships. These findings emphasize that age of use onset for alcohol and illicit drugs can be valuable in identifying offenders at risk of severe substance use in adulthood.
Improved Vectors for Selecting Resistance to Hygromycin

Resistance to hygromycin B is an important dominant selectable marker in fungal transformation. Our goal was to improve vectors for hygromycin selection by making the gene more compact, by eliminating sites for commonly used restriction enzymes, and by subcloning the modified gene into convenient vectors. These improvements were made by modifying pCSN43 (Staben et al. 1989 Fungal Genetics Newsl. 36:79-81) through three rounds of megaprimer mutagenesis (Aiyar and Leis, 1993 Biotechniques 14:366-368 ), a technique based on polymerase chain reaction amplification. Plasmid pCSN43 has a 2.4 kb SalI fragment containing the bacterial hph gene (Gritz and Davies, 1983 Gene 25:179-188), encoding hygromycin B phosphotransferase, under control of the Aspergillus nidulans trpC promoter and terminator (Mullaney et al. 1985 MGG 199:37-45) (Fig. 1a).
Soil water infiltration measurements using the double ring and cornell infiltrometer in a Rhodic Hapludox

The value of soil water infiltration is very important in several areas, such as agriculture, water resources, engineering projects. The methods to determinate the water infiltration in general is difficult and produce often unreliable results. The work aimed to evaluate the soil water infiltration rate in a Rhodic Hapludox under three management systems. The results were compared using two methods to determine the water infiltration rate. In the three management systems, the water infiltration rate in the soil was determined using the double ring infiltrometer. Using this method the results showed higher values when compared to the Cornell infiltrometer. For both methods, the native forest presented the highest soil water infiltration rate, followed by the no tillage area and perennial pasture grown. Through the double ring infiltrometer the infiltration rates obtained were 1428.2 mm h-1 (Forest), 46 mm h-1 (no tillage) and 22.6 mm h-1 (perennial pasture). Considering the Cornell infiltration method, the same areas showed infiltration rates of 300, 33.2 and 12.7 mm h-1, respectively. In the native forest the runoff process was not verified, while ingress with no tillage and perennial pasture. In these areas the runoff is started, respectively, at 3.25 and 1.33 minutes after the beginning of the tests.
THE ROLE OF CARCINOEMBRYONIC ANTIGEN IN ASSESSING THE SUCCESS OF SURGICAL TREATMENT IN COLORECTAL CANCER BASED ON STAGING

Colorectal cancer is the third most common cancer in Indonesia. Determination of staging is needed to determine the treatment of colorectal cancer which has four stages. Carcinoembryonic Antigen (CEA) is a serological marker for monitoring colorectal cancer status, prognostic determination, monitoring of treatment success, detecting early recurrence and spreading. The purpose of this study was to determine the evaluation of successful surgical therapy in colorectal cancer by CEA examination at each stage. Descriptive observational studies were conducted using secondary data of pre and post-surgical colorectal cancer patients examined for CEA and treated at the Dr. Soetomo Hospital from January 2015 to December 2016. The samples obtained from this study were 48 patients, with the most of them at the age of 41-60 years as much as 70.83%. Females were more than males (66.67% vs. 37.33%). The most staging stage, stage 4 was as much as 43,75% followed by stage 3 as much 41.67%, the rest were stage 1 as much as 10.42%, and stage 2 as much as 4,17%. The highest decrease in CEA levels was found in stage 4 by 85%, followed by stage 2 of 53.5%, stage 1 of 43.4% and stage 3 of 33.1% but statistically only the decrease in stage 3 was significant. In stage 1, there was a difference in pre-operative CEA with a mean of 3.09 ng/mL (0.17-5.83 ng/mL) vs. post-operative with a mean of 1.75 ng/mL (0.84-3.14 ng/mL), stage 2 levels of pre-operative CEA with a mean of 3.82 ng/mL (0.15-7.48 ng/mL) vs. post-operative with a mean 1.77 ng/mL (1.46-2.08 ng/mL), stage 3 levels of pre-surgical CEA with a median of 13.85 ng/mL (1.09-71.21 ng/mL) vs. post-operative with a median 9.26 ng/mL (<0.5-68.23 ng/mL), stage 4 pre-surgical CEA levels with a median 183.77 ng/mL (0.54-2861 ng/mL) vs. post-operative with a median 27.28 ng/mL (0.51-155.10 ng/mL). There was a decrease in CEA levels from the total number of patients by 67%, whose CEA levels remained at 12% and as much as 21% of their CEA levels increased. Successful evaluation of surgical therapy in the colon and rectal cancer by CEA examination was still varied at each stage where CEA levels decreased significantly in stage 3.
Seamless Mobility Under a Dedicated Distributed Antenna System for High-Speed Rail Networks

High-speed railway (HSR) has demonstrated tremendous growth worldwide, and is currently attaining a maximum velocity of 575 km/h. Such a high speed makes mobile wireless communications extremely challenging for HSR since the handover (HO) rate increases with speed, resulting in a high call dropping probability. By employing a dedicated distributed antenna system (DAS) along with the two-hop network architecture, in this paper, we propose a frequency switch (FSW) scheme to mitigate the persistent HO issue in conventional HSR wireless communication systems. The proposed scheme significantly alleviates interruption time associated with the traditional HO process, providing an effective scheme when the train moves across small cells covered by remote antenna units (RAUs) belonging to the same central unit (CU). In order to further reduce the HO command failure probability, an enhanced fast predictive HO mechanism is proposed by starting the HO process in advance, when the train moves from one RAU to the next one controlled by the adjacent CU. Analytical results show that compared to the traditional HO scheme, the proposed schemes can improve the system performance substantially by delivering ultra-reliable low-latency communications with a reduced HO/FSW rate.
Reliability Enhancement of Modular Smart Transformers by Uneven Loading of Cells

A Smart Transformer (ST) is a power electronics based transformer developed for the electrical distribution grid, where it can provide many advanced grid services. The advanced functionality comes with the concern of lower reliability affected by the complexity and the higher number of components. To overcome the reliability concerns, this work pro-poses to utilize a modular architecture for routing the power in the cells such that cells with shorter remaining lifetimes are less stressed and the time to the next failure in the system is delayed. temperature sensors, National Instruments data acquisition and control system, the three parallel converters assembled on one heat sink and high speed infrared camera for junction temperature measurement.
Enhanced threshold schemes and their applications

Techniques that distribute data across multiple players in such a way that a threshold number of players can reconstruct the data, whilst any fewer than the threshold cannot learn information about the data, are well established. These techniques are called threshold schemes and are important as they allow for increased availability, add redundancy and offer security without the reliance on cryptographic keys. With constrained devices restricted by low computational capabilities becoming more prevalent, it is important to discuss the use of threshold schemes in this setting. We study efficient threshold schemes and their applications in constrained devices and illustrate the compromise between efficiency and security. We begin by using combinatorial techniques to propose an ideal, efficient, perfectly secure threshold scheme, which we analyse and compare to existing efficient threshold schemes. We show our scheme is efficient, with respect to the number of bitwise operations, compared to other schemes. Next, we revisit a computationally secure threshold scheme, called AONT-RS, originally proposed in 2010. We generalise the scheme to allow for greater cryptographic flexibility and prove the scheme to be secure in the random oracle model. When compared to Krawczyk’s scheme, the generalised scheme is more efficient, but requires greater assumptions in order to be proven secure. We then discuss extending AONT-RS to be robust, which prevents the unauthorised alteration of data. Following this, we consider repairable threshold schemes, which enable recovery of a corrupted share without the help of a dealer. We consider and refine existing methods, analysing the storage costs and bandwidth required for each repair. We introduce a new metric to measure the repairability of the scheme, then consider secure regenerating codes and applying these techniques to repairable threshold schemes. We finish by comparing a range of techniques and highlight how they find a compromise between bandwidth and storage. Finally, we propose localised multi-secret sharing schemes, which are multi-secret sharing schemes for an ordered set of players in which a sufficient number of sufficiently close players are able to recover secrets. We define threshold versions of localised multi-secret sharing schemes, provide lower bounds on the share size and give explicit constructions of schemes to show these bounds are tight. We then analyse a range of approaches to relaxing the model that provides a trade-off between the share size and the security provided by the scheme. Finally, we explore applying localised threshold multi-secret sharing schemes to RFID enabled supply chains.
Morphological variations of selected coccolith species in a sediment trap north of the Canary Islands.

Biometrical analyses were performed on nearly 3200 specimens of distinct coccolith species from the time-series station ESTOC (European Station for Time-series in the Ocean, Canary Islands). Originally begun for calculation of modern species-specific carbonate fluxes, this study was further intensified, both to improve our knowledge of the morphological variability for each of the investigated species, and to check the seasonal size-variations of the various species. Besides the dominant taxa Emiliania huxleyi and Florisphaera profunda, intensive measurements of various parameters have been made on Calcidiscus leptoporus, Gephyrocapsa spp. , Helicosphaera carteri, Syracosphaera pulchra, and Umbilicosphaera sibogae. Generally, the species are unimodally distributed, with respect to length/diameter, and show only slight seasonal variation.
Development of a guidance system for tourism by using archived data

In recent years, many tourists use their smartphones to receive tourism information, check a map, and take photos of tourism spots. We consider that it is very effective to use a smartphone application to provide tourism information. The goal of this research is developing a system for guiding people naturally from one spot to another. For that, we developed an Augmented Reality smartphone application using archived old photo data kept in museums, libraries, and local governments’ institutions. In addition, we developed a system to upload photos taken by users and exhibit those photos with old photos at a museum. In this research, we implemented an experiment performed using the application and exhibition, and collected feedback with a questionnaire. After showing the results of the experiment, we consider the possibility of utilizing open data in tourism.
Machine learning driven interpretation of computational fluid dynamics simulations to develop student intuition

Employers need engineers capable of leveraging CFD simulations to make intelligent design decisions, but undergraduate computational fluid dynamics (CFD) courses are not adequately preparing students for this type of work. CFD courses commonly familiarize students with topics, such as method derivation, domain creation, boundary conditions, mesh convergence, turbulence models, numerical convergence, and error analysis. This approach is an effective way to teach novices how CFD software works and how to prepare CFD analyses. However, it neglects development of higher level CFD skills and intuition important to engineering analysis and design, deferring this task to future study and training. This paper introduces the “Machine Learning Driven Interpretation of Fluid Dynamics Simulations to Develop Student Intuition” (MIFoS) software, a program designed to help CFD novices develop the high‐level skills and intuition that employers need in their engineers. A data‐driven approach was used to create the MIFoS software, which allows the submission of arbitrary geometries, automates an external flow simulation, and returns expert‐level graphical interpretation of simulation data. MIFoS's automated CFD simulation and feedback space allows novices to experiment with expert‐level suggestions on their own designs, enabling the skill and intuition development typically gained through years of study, practice, and expert guidance.
Vision-Based Vehicle Detection for VideoSAR Surveillance Using Low-Rank Plus Sparse Three-Term Decomposition

Automatic vehicle detection from a video synthetic aperture radar (VideoSAR) system presents significant potential to enhance the surveillance performance in dynamic region of interest (DROI). In this paper, a novel VideoSAR low-rank plus sparse decomposition (LRSD) perspective for single-channel single-pass configuration is proposed to track the ground defocusing vehicles. Vehicle imaging features with 2-D motion parameters are derived theoretically by exploiting a priori knowledge of polar format algorithm (PFA). In accordance with the revealed characteristics, a vision-based VideoSAR-LRSD algorithm, called three-term decomposition (TTD) with proximal exchange-based alternating directions method of multipliers (PEADMM), is then proposed to improve the performance of vehicle detection. It can be used to break the limitation for the application of emergency response not permitting the acquisition of multi-channel or multi-pass data. We comprehensively demonstrate using extensive VideoSAR DROI experiments that in comparison with the state-of-the-art algorithms, TTD-PEADMM algorithm presents the improved accuracy and is able to offer competitive results.
Performance Analysis of AODV Protocol on MANET’s Model with ViSim

The usage of the MANET network models had increased a lot in the recent years due to various advantages of these networks. The major advantage was the size of the model and the network topology. The network of these models changes from time to time due to the reason that the addition of nodes and separation of nodes to the network model is always possible and very frequent in these network models. Hence, it is very important and required to analyze the performance of these networks with the help of various routing protocols. The performance had analyzed with various performance metrics like the end to end delay of the network model, output of the network etc. The results are displayed and discussed in detail in the results section.
Identification of genes and the signal transduction pathways involved in the regulation of acetic acid-induced programmed cell death

After many years of research, S. cerevisiae was accepted as a powerful model that allows increasing our comprehension about the underlying mechanisms of apoptosis in more complex and less accessible organisms. So, to better understand these apoptotic mechanisms we performed a functional analysis, at whole-genome scale, with the Euroscarf mutants collection. This analysis reveled 2159 resistant mutants and 391 mutants more sensitive to acetic acid induced cell death than the parental strain BY4741. The results obtained contribute to further characterize acetic acid-induced programmed cell death (PCD), and provide information on new putative targets for its control. Most of the studies on apoptosis in yeast have been centered in the identification of apoptotic markers, however less is known about the signal transduction pathways that induce apoptosis. Cells possess a network of signal transduction pathways, which allow them to respond to different stimulus, implying several changes in genetic expression. Sfl1p is a transcription factor (TF) involved in repression of flocculation-related genes, and activation of stress responsive genes. We studied, cell death induced by acetic acid in yeast strains deleted in SFL1 and in genes potentially regulated by Sfl1p (AQY2, FMP42, FMP45, SUC2, HSP30, HSP104, NNF2, FLO1 FLO8, YMR173W-a, YJR11W e YCR006C). The results obtained suggest that Sfl1p and the genes under its regulation, share a role in the mediation of acetic acid-induced apoptosis. Slf1p harbors 3 domains characteristic of the c-myc oncoprotein, a transcription factor with an important role in apoptosis induction and often found mutated in cancer cells. Our results showing that Sfl1p is also involved in the regulation of apoptosis in yeast suggest that these domains can have a conserved function in apoptosis regulation across kingdoms. We also studied the involvement of genes regulated by Rlm1p on cell death induced by acetic acid. This TF coordinates an adaptive transcriptional response to the stress induced in the cell wall. Our results show that the genes that confer stability to the cell wall, confers sensitivity to acetic acid, when mutated. On the other hand, the genes involved in the cell wall formation, confers resistance, when mutated.
El ganado bovino ibérico en las Américas: 500 años después

El bovino criollo americano desciende directamente de los animales que llegaron en el segundo viaje de Colon en 1493. Estos animales, asi como posteriores envios, llegaron a la isla denominada La Espanola, hoy asiento de la Republica Dominicana y Haiti. Las similitudes entre las razas criollas de Brasil y de Hispanoamerica pueden explicarse por la proximidad geografica de sus origenes. Con el objetivo de definir el ganado criollo se describen sus caracteristicas morfologicas y de comportamiento en Latinoamerica.
FATCO syndrome: a new case and review of the literature

Fibular aplasia, Tibial Campomelia, and Oligosyndactyly (FATCO) syndrome is a very rare syndrome. The inheritance pattern of this syndrome and responsible gene or genes are unclear. Until today, only 14 patients have been reported. Herein, we have presented a new male patient with FATCO syndrome. In order to define the clinical features other than the major ones, we had an overview of the phenotypical findings of this rare syndrome by comparing the clinical findings of our case with those of the published cases Pam Med J 2016;9(3):236-239
Acute Kidney Injury and Creatine Kinase Elevation After Beginning Treatment with Levetiracetam

L evetiracetam (LEV) is one of the most common anti-epileptic drugs available. In general, it is tolerated relatively well; the majority of adverse effects are moderate and normally occur during the initial titration. We present a patient who developed two moderately serious adverse effects after an initial LEV dose: a 28-year-old male was admitted to intensive care unit after suffering two generalised seizures, and was given 1000 mg of LEV. Twenty-four hours after admittance, the laboratory tests showed a serum creatinine of 2.84 mg/dL and creatine kinase (CK) of 421 U/L (normal, 0–171 U/L). At all times the diuresis was normal, with a maximum value of creatinine of 4.67 mg/dL 48 hours following admittance, and the CK values ranged between 421–681 U/L with proteinuria of 840 mg/day. On the seventh day, blood tests showed a CK of 1,559 U/L and a creatinine of 1.55 mg/dL. LEV was progressively substituted for lacosamide, after which creatinine, CK and albumin excretion rate were normalised. Thus, CK and renal function during treatment with LEV should be monitored, and acute kidney injury due to LEV should be considered in the differential diagnosis for any unexplained acute renal failure.