Miracle-dz/UniFAR-FTUs huggingface dataset:
Isolated Loco-Regional Recurrence of Breast Cancer – Established andInnovative Therapy Concepts

The incidence of isolated loco-regional recurrence of breast cancer is between 2–20 %. It constitutes the most common type of breast cancer recurrence. In contrast to distant metastasis, a number of curative therapies are available to treat isolated loco-regional recurrence of breast cancer. Screening for early detection and regular examinations as part of a recommended follow-up programme is important. If distant metastasis has been excluded, therapy for recurrence ideally consists of surgery with R0 resection margins. Radiotherapy is indicated after non-curative surgery (R1/R2) for local tumour control to improve the chances of curative surgery and as a palliative therapy for local control of symptoms in inoperable cancer, also in combination with hyperthermia and systemic therapy. There was previously some uncertainty concerning the benefit of systemic therapy after R0 resection and breast-conserving therapy and after previous mastectomy. If the recurrence is hormone-receptor positive, (repeat) endocrine systemic therapy is indicated for both constellations. If the hormone-receptor status is negative, the question whether repeat chemotherapy is indicated as an adjuvant therapy and whether it offers a benefit to patients was still controversially discussed. However, data from the CALOR trial presented at the San Antonio Breast Cancer Symposium in 2012 has now answered this question in favour of chemotherapy. These new findings will not merely have an impact on future therapy recommendations but also on the entire clinical management of isolated loco-regional recurrence.
Effect of a citrus extract (NOR-SPICE AB) on broiler performances.

the diets obtained by GC/MS during this study are presented in the Table. The standard error percentage for the quantification of diets containing solely thymol or carvacrol alone were 12% and 4%, respectively. In the diet containing both thymol and carvacrol, the concentration deviated from the standard by approximately 8%. This study confirms the potential of modern laboratory techniques for the qualitative and quantitative traceability of phytogenic molecules in diets, although further research is needed to establish individual limits of detection of these compounds under different diet formulations. Furthermore, these methods may be used to verify the stability of these active substances when included in a variety of feed premixes and under current pelleting, expander or extruder conditions.
The effect of audibility, signal-to-noise ratio, and temporal speech cues on the benefit from fast-acting compression in modulated noise

The objective of the experiment was to investigate three aspects that might contribute to the benefit of fast-acting compression seen in normal-hearing listeners. Six normal-hearing listeners were tested with speech recognition in a fully modulated noise (FUM) either through a fast-acting compressor or through linear amplification. In the first experiment, three different presentation levels of the FUM noise (15, 30, and 45 dB SL) were tested. The second experiment manipulated the control signal of the compressor independently of the audio input signal at four signal-to-noise ratios (−15, −10, −5, and 0 dB). A signal correlated noise version of the speech signal was tested in the third experiment at three speech-to-noise ratios (−20, −15 and −10 dB). Results showed that performance was better with compression than with linear amplification through all of the tested conditions at least when the signal-to-noise ratio was negative. The results suggest that other aspects of the hearing impairment than those simulated here are involved in the degraded performance seen for some hearing-impaired listeners with fast-acting compression.
Cambodia - Sustaining rapid growth in a challenging environment : country economic memorandum

Many countries succeed in generating high economic growth at some point in their history. But only a very few manage to sustain rapid growth for an extended period. Only such a prolonged period of rapid growth can have a significant impact on income per capita, and such an impact often brings with it many other important changes to people's lives. Cambodia has more than doubled its income per capita over the past decade, from US$285 in 1997 to US$593 in 2007. This doubling has been accompanied by the trappings of a profound structural transformation: integration into the global economy; a shift of jobs from agriculture to manufacturing; a demographic transition; and migration from rural to urban areas. Translating into jobs and better services, these outcomes have led to a significant reduction in poverty, as well as improvements in health and education. This report aims to contribute to policymakers' and citizens' thinking about growth in Cambodia in three ways: (i) it reviews the experience of the past decade and draws the Cambodia-specific lessons of this period; (ii) it sketches the major potential sources of growth with the aim of assessing the barriers to growth; and (iii) it outlines policy options for addressing these barriers.
Reaching for the Stars: Is Matching of High Ability Individuals and High Wage Firms Rent Creating?

Employees in elite firms are well compensated compared to industry standards, and the important questions for strategic management of human capital are whether there is a rent from matching high ability individuals and to high wage firms, and whether firms get a share of this rent. We examine whether firm performance is related to positive assortative matching of high ability managers and workers to high wage firms. We develop a synthesis of human capital and efficiency wage theories and analyze the matching of manager and worker abilities to efficiency wages in a sample of 3,033 Danish small and medium-sized firms. Our findings support an association between financial performance and positive assortative matching of managers with firms while the evidence is not in favor of positive assortative matching of workers and firms.
Effect of Service Quality Dimensions on Customer Satisfaction: A Comparative Analysis of Pakistan Telecom Sector

The purpose of this study is to establish the relationship between service quality and customer satisfaction. Two main dimensions of service quality were taken i.e. reliability and empathy. This is a quantitative analysis and the data was collected in the form of communication-based questionnaires. The sample size was 400 respondents and four main telecom service providers were considered for the study. The results were calculated by analytical software SPSS-20. It was concluded that service reliability and service empathy both have an effect on customer satisfaction. It was also determined that some factors were more satisfactory than the others. The findings of study reveal that percentages of customer satisfaction change with the service quality dimensions of reliability and empathy. Overall, it can be established that there is a significant relationship between customer satisfaction and service quality dimensions of empathy and reliability. Keywords: Service Quality, Empathy, Reliability, Customer satisfaction.
The links between complex coronary disease, cerebrovascular disease, and degenerative brain disease

Our appreciation of the complexity of cardiovascular disease is growing rapidly. Consistent with the fact that the vasculature is an omnipresent system that carries blood to every organ in the body, an expanding number of conditions are now known to be directly associated with disturbed cardiovascular function or vascular pathology. In particular, cardiovascular disease has recently been implicated as playing a major role in dementia and other forms of degenerative brain disease. Here, we explore some of the many emerging relationships between cardiovascular risk factors, complex coronary artery disease, cerebrovascular disease, and degenerative brain disease.
A controlled study of intravenous immunoglobulin in demyelinating neuropathy with IgM gammopathy

Eleven patients with demyelinating polyneuropathy associated with monoclonal IgM antibodies were randomized to receive IVIg or placebo, monthly, for 3 months in a double‐blind study. After a washout period, they crossed over to the alternate therapy. Response was gauged by evaluating muscle strength, sensation, and neuromuscular symptoms at baseline, after 3 months, and at treatment's end. After IVIg therapy, the strenght improved in only 2 of 11 patients, by 28 and 38.5 points from baseline, and declined after placebo. In 1 other patient, the sensory score improved by 13 points. Antibody titers to MAG/SGPG or gangliosides did not appreciably change. We conclude that IVIg has only a modest benefit to not more than 18% of patients with IgM paraproteinemic demyelinating neuropathy.
Supplier‐manufacturer relationships In the Brazilian auto industry: an exploration of distinctive elements

This study aims to identify the presence of commitment, cooperation and interdependence, in the relations established between suppliers and automobile manufacturers as described in the extant relationship marketing theory, Case studies of the three biggest Brazilian automobile manufacturers were carried out, depicting the existing relations, the routines in these relations and the standards governing such relations.
The Role of Marketing Actions with a Social Dimension: Appeals to the Institutional Environment

The interaction between marketing actions with a social dimension and marketing actions with an economic orientation is at the heart of this study. The authors introduce institutional theory as the theoretical lens used to inform this research. Results from an experiment in a retail context show that there is a minimum acceptable level of marketing actions with a social dimension, below which the effectiveness of a firm's economic-oriented actions is hindered significantly.
Effects of a 16-month randomized controlled exercise trial on body weight and composition in young, overweight men and women: the Midwest Exercise Trial.

BACKGROUND In light of the current obesity epidemic, treatment models are needed that can prevent weight gain or provide weight loss. We examined the long-term effects of a supervised program of moderate-intensity exercise on body weight and composition in previously sedentary, overweight and moderately obese men and women. We hypothesized that a 16-month program of verified exercise would prevent weight gain or provide weight loss in the exercise group compared with controls. METHODS This was a randomized controlled efficacy trial. Participants were recruited from 2 midwestern universities and their surrounding communities. One hundred thirty-one participants were randomized to exercise or control groups, and 74 completed the intervention and all laboratory testing. Exercise was supervised, and the level of energy expenditure of exercise was measured. Controls remained sedentary. All participants maintained ad libitum diets. RESULTS Exercise prevented weight gain in women and produced weight loss in men. Men in the exercise group had significant mean +/- SD decreases in weight (5.2 +/- 4.7 kg), body mass index (calculated as weight in kilograms divided by the square of height in meters) (1.6 +/- 1.4), and fat mass (4.9 +/- 4.4 kg) compared with controls. Women in the exercise group maintained baseline weight, body mass index, and fat mass, and controls showed significant mean +/- SD increases in body mass index (1.1 +/- 2.0), weight (2.9 +/- 5.5 kg), and fat mass (2.1 +/- 4.8 kg) at 16 months. No significant changes occurred in fat-free mass in either men or women; however, both had significantly reduced visceral fat. CONCLUSIONS Moderate-intensity exercise sustained for 16 months is effective for weight management in young adults.
Helping various stakeholders to understand a very large component-based software

Nowadays many software products are made up of millions of lines of code. Moreover, they are subject to a continuous evolution. These products are often bused on component technologies such as COM, EJB or Corba. Understanding and controlling the evolution of such complex software products is a difficult task, especially if undertaken at the code level. It is thus necessary to reason at a higher level of abstraction, i.e. the software architecture. This article reports on an industrial experience. The goal was to answer Dassault Systemes' needs by using a software architecture approach. This company maintains and develops a huge software called CATIA. In this article, we show how the architecture of CATIA can be described by the use of multiple, concurrent architectural views. This allows both to separately address the concerns of the various stakeholders of the architecture and to improve the communication between these different stakeholders.
Clinical characteristics of pneumonia in hospitalized patients with novel influenza A (H1N1) in Korea

Abstract In March 2009, a novel influenza H1N1 virus (2009 H1N1) emerged and spread worldwide. We describe the clinical course of pneumonia in patients hospitalized with 2009 H1N1 in Korea from August to mid-October 2009. Of 351 patients with a confirmed 2009 H1N1 infection, a total of 17 patients with pneumonia were admitted to an acute care unit. More than half of the patients were between 7 and 23 y of age, and only 2 patients were 65 y of age or older. Only 6 patients (35.3%) had underlying medical conditions. For 10 of the 17 patients, chest radiographs taken on admission had findings of pneumonia with bilateral infiltrates. Despite intensive resuscitative efforts, 1 adult patient arriving with severe hypoxemia in the emergency department died 3 weeks later. However, we were able to discharge most of the patients without any other complication in 5 days. 2009 H1N1 was the cause of pneumonia with mild hypoxemia at admission in previously healthy school-aged persons in Korea.
The Impact Of Outside Director Equity Holdings On The Mix Of Outside Director Compensation

This study investigates the impact outside director equity holdings have on the determinants of the mix of equity in outside director compensation plans. The analysis, conducted over a 4 year period from 1997-2000, is based on a sample of 89 first time adopters of equity compensation. The use of first time adopters attempts to control for the fact that many of the variables in the study are endogenously determined over time. The results indicate that the mix of equity is negatively associated with outside director holding, positively associated with the market-to-book ratio (a measure of the firms investment opportunities) and negatively associated with return on assets (a measure of CEO bargaining power). These findings suggest that the negotiation that takes place between the CEO and outside directors regarding governance is not only affected by the firms wanting to match the marginal productivity of directors with the opportunities of the firm, but also with the equity holdings of the directors.
Wrong Gallery: A New Paradigm for Art Space

This case gives a depiction of how the founder of Wrong Gallery, Ron, when facing the competition and operational mode of the traditional art gallery industry in Taiwan, capitalizes on the latest trend of emergent social media, and leads his team to break through the shackles or consumers' stereotypical impression. Ron has set up a brand-new age of art space with the brand thinking and innovative approaches, becoming a practical case in regard of the new-pattern art space. In an era where the total value of output from cultural and creative industries worldwide is rapidly increasing, this case's rich materials give readers a better understanding of the operation of an art gallery amongst the cultural and creative industries. This case allows readers to understand how an innovative enterprise's founder starts by analyzing industry situations, incorporates his/her personal strengths, and further determines the strategy application and implementation for the company's market position and business operation model.
Update on daptomycin: the first approved lipopeptide antibiotic

Daptomycin, the first approved member of the lipopeptide antibiotic class, exhibits potent bactericidal in vitro activity against most Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus species and penicillin-resistant Streptococcus species. Since its approval in 2003 for the treatment of complicated skin and skin structure infections, several review articles have summarised daptomycin’s mechanism of action, pharmacokinetics, pharmacodynamics, clinical trials and safety profiles. The objective of this paper is to summarise past information with a focus on the latest susceptibility data of isolates collected worldwide, new pharmacodynamic studies, clinical data regarding bacteraemia/endocarditis and postmarketing surveillance in the treatment of skin and skin-structure infections.
Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma.

HYPOTHESIS A subset of patients with hepatocellular carcinoma (HCC) with a diameter of 10 cm or larger may benefit from hepatic resection. DESIGN Retrospective study of a multi-institutional database. SETTING Five major hepatobiliary centers. PATIENTS We identified 300 patients who underwent hepatic resection for HCC 10 cm or larger. MAIN OUTCOME MEASURES Clinical and pathologic data were collected, and prognostic factors were evaluated by univariate and multivariate analyses. Patient survival was stratified according to a clinical scoring system and pathologic T classification. RESULTS The perioperative mortality rate was 5%. At a median follow-up of 32 months, the median survival was 20.3 months, and the 5-year actuarial survival rate was 27%. Four clinical factors-alpha-fetoprotein of 1000 ng/mL or higher, multiple tumor nodules, the presence of major vascular invasion, and the presence of severe fibrosis-were significant predictors of poor survival (all P<.05). Patients were assigned a clinical score according to the following risk factors: 1, no factor; 2, one or two factors; or 3, three or four factors. On the basis of the clinical score, patients could be stratified into only 2 distinct prognostic groups: no factor (score of 1) vs 1 or more factors (score of 2 or 3) (P<.001). In contrast, when patients were stratified according to pathologic T classification, 3 distinct groups were identified: T1 vs T2 vs T3 and T4 combined (P<.001). Fifty-six percent of the patients with a clinical score of 2 and 20% of patients with a clinical score of 3 actually had T1 or T2 disease on pathologic examination. CONCLUSIONS Patients with large HCCs should be considered for liver resection as this treatment is associated with a 5-year survival rate exceeding 25%. Clinical predictors should not be used to exclude patients from surgical resection because these factors do not reliably predict outcome.
Image Databases for Multimedia Projects

Cet article presente des projets de multimedias images europeens bases sur les musees, les bibliotheques et d'autres organismes documentaires. Apres une presentation de l'European Commission Programms qui a mis en place ces projets, deux programmes britanniques sont plus specialement etudies : le British Library Research et le Development Departement Imaging Programme
Analysis of the Competition of the Express Market in China

Since the all-round open in Chinese express market to the foreign companies,all state-owned and private express companies have experienced a great impact by the competition of foreign express companies such as FedEx and UPS,which results in an ongoing slide in the market share.This paper firstly analyzes the development and the present state of express market in China.Then based on an analysis of the abilities competition situation,the present competitors and relative forces which may influence the competitive of Chinese express companies,this paper proposs key solutions to improve competitive abilities,such as the government's encouragement,self-innovation of the system in the state-owned and private express companies and the brand building.
Prophylaxis with Lamivudine of Hepatitis B Virus Reactivation in Chronic HbsAg Carriers with Hemato-oncological Neoplasias Treated with Chemotherapy

Reactivation of hepatitis B virus (HBV) infection is well documented complication of cytotoxic or immunosuppressive therapy in asymptomatic HBV carriers. Its clinical manifestation include fulminant hepatitis which may result in fatal liver failure. With the more widespread use of chemotherapy and hematopoietic stem cell transplantation, the problem of delivering potentially harmful treatment to HBV carriers is becoming increasingly frequent. Until recently the management of HBV reactivation has been mainly supportive. With the introduction of lamivudine, a highly effective nucleoside analogue against HBV with an excellent toxicity profile has become available. However, in light of the possibility that its prolonged use may foster the emergence of mutant lamivudine-resistant HBV strain, caution is required before recommending its widespread use. The present review briefly addresses the epidemiological, pathogenetic and clinical aspects of HBV reactivation as well the predisposing factors to its development. The results obtained with lamivudine both as treatment and as prophylaxis of hepatic flares are analysed in detail in order to provide a rational basis for clinical decisions before treating HBV carriers with chemotherapy.
Metal artifact reduction in computed tomography using nonequispaced fourier transform

Metal objects in the field of view of a computed tomography (CT) scanner cause several artifacts inside the reconstructed image. By reducing the influence of these metallic objects the image quality can be enhanced. We propose a metal artifact reduction (MAR) method based on interpolation using Nonequispaced Fast Fourier Transforms (NFFT). By damping the transformation additional a priori knowledge may be included during the interpolation step. The results are reconstructed with a weighted maximum likelihood expectation maximization algorithm (¿-MLEM) and finally compared to two common one dimensional polynomial interpolation methods.
Acute Lung Injury and Acute Respiratory Distress Syndrome: Extracorporeal Life Support and Liquid Ventilation for Severe Acute Respiratory Distress Syndrome in Adults

Acute respiratory distress syndrome (ARDS) has many underlying causes and carries an overall mortality of 40 to 60%. For those patients with severe ARDS who have a predicted mortality of 80 to 100%, extracorporeal life support (ECLS) can provide an extraordinary means of support. We recently demonstrated a survival to hospital discharge of 52% in this subset of patients. ECLS is capable of providing full respiratory and cardiac support, allowing time for the patient to recover from the underlying disease process. Additionally, ventilator settings are reduced to "rest" settings, avoiding the consequences of ventilator-induced lung injury that can contribute to a worse outcome. Systemic heparinization is a mainstay of ECLS therapy because of platelet activation in the circuit. Mechanical complications and significant bleeding can occur in up to one quarter of patients, requiring close attention and prompt intervention should they occur. Although not currently in clinical practice, liquid ventilation using perfluorocarbons to provide gas exchange in the lungs is a potentially useful adjunct in the management of severe respiratory failure.