Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety and immunogenicity of an HLA‐based HIV envelope polyvalent synthetic peptide immunogen

Objective:To evaluate the safety and immunogenicity of a polyvalent (PV) HIV envelope synthetic peptide immunogen, C4-V3. The immunogen comprised four peptides containing T-helper epitopes from the fourth constant region (C4) of gp120 of HIV-1MN, and T-helper, cytotoxic T-lymphocyte HLA-B7-restricted, and B-cell neutralizing epitopes from the gp120 third variable region (V3) of four clade B HIV-1 isolates, HIV-1MN, HIV-1RF, HIV-1EV91, and HIV-1Can0A. Design:A pilot, Phase I controlled trial [Division of AIDS Treatment Research Initiative (DATRI) 010] conducted at a single center. Methods:Ten HIV-infected, HLA-B7-positive patients with CD4 cells > 500 × 106/l were enrolled. Eight patients received the C4-V3 PV immunogen emulsified in incomplete Freund's adjuvant in five intramuscular injections over 24 weeks, and two controls received incomplete Freund's adjuvant alone. All subjects were followed for 52 weeks. Results:Four out of eight C4-V3 PV recipients generated at least fourfold rise in serum antibody titers to at least three immunogen peptides in contrast to none of the control subjects. Four out of eight C4-V3 PV recipients and none of the controls had an at least fourfold rise in neutralizing antibodies to either HIV-1MN, HIV-1RF, or HIV-14489-5 laboratory-adapted HIV isolates. 3H-Thymidine incorporation assays of peripheral blood mononuclear cells increased at least fivefold over the baseline stimulation index to at least one of the immunogen peptides in two consecutive post-immunization timepoints in five out of eight C4-V3 PV recipients versus none of the controls. CD4 cell counts and plasma HIV RNA levels did not change in patients who received either C4-V3 PV or adjuvant alone. Adverse events consisted primarily of grade 1 injection site reactions in six subjects (four C4-V3 recipients, two controls). Conclusions:C4-V3 PV synthetic peptides demonstrated both immunogenicity and safety in HIV-infected patients.
The Uses of the University

A definite idea of the university is the product of the times. As university s social being has been changeable, its-idea must be changed as time goes on. Futuristic universities must be re-classified: one is so-called brand-name university, uses of which are to contribute knowledge; another so-called mass-provider university, uses of which are provide trained personnel, namely, to train learned, skilled and numerous workers. It is the key to understand the uses of university when we discuss the ideas of university.
One State’s Systems Change Efforts to Reduce Child Care Expulsion

This article describes the efforts funded by the state of Colorado to address unacceptably high rates of expulsion from child care. Based on the results of a 2006 survey, the state of Colorado launched two complementary policy initiatives in 2009 to impact expulsion rates and to improve the use of evidence-based practices related to challenging behavior. The primary policy initiative involved the funding of a center to develop model sites, a state-level planning team, ongoing practitioner training, and certification of coaches and trainers all built around the Pyramid Model. The secondary initiative involved expanding the number of early childhood mental health consultants and modifying their reimbursement/payment formula such that direct preventative work with adult providers, consistent with the Pyramid Model, was reimbursable. A follow-up survey in 2011 showed a dramatic reduction in expulsion rates and a corollary increase in providers’ teaching of prosocial skills to children with challenging behavior.
Nutritional habits providing optimal calcium and vitamin D3 supply

Prawidłowy sposób żywienia odgrywa istotną rolę w profilaktyce i leczeniu osteoporozy. Wśród czynników żywieniowych wpływających na stan kośćca ważne znaczenie ma nie tylko właściwa podaż wapnia i witaminy D3, lecz także białka, magnezu, potasu, cynku, manganu, miedzi, witaminy K, witaminy B6 oraz kwasu askorbinowego. Przyswajalność wapnia z diety waha się od 10% do 40% i zależy od rozpuszczalności formy chemicznej oraz składu diety. Do czynników zwiększających wchłanianie wapnia należą laktoza, inulina, niektóre fruktooligosacharydy i fosfopeptydy kazeiny, lizyna oraz arginina. Obecność w diecie takich składników, jak kofeina, fityniany, szczawiany, nierozpuszczalne frakcje błonnika, a także nadmierna podaż tłuszczu, fosforu, alkoholu i soli kuchennej wpływa na obniżenie biodostępności i przyswajalności wapnia. Edukacja żywieniowa oraz modyfikacja zachowań żywieniowych u pacjentów z osteoporozą są istotnymi czynnikami profilaktycznymi postępu choroby. Słowa kluczowe: osteoporoza, sposób żywienia, zalecenia żywieniowe.
Tomographie de diffraction et synthèse de Fourier à maximum

In diffraction tomography, the generalized Radon theorem relates the Fourier Transform (FT) of the diffracted field to the two-dimensional FT of the diffracting object. The relation stands on algebraic contours, which are semi-circles in the case of Born or Rytov first order linear approximations. To increase the insufficient resolution of generally used interpolation methods we propose a Maximum Entropy Fourier synthesis method. To do this, we give a new definition for the entropy of an object considered as a function of R2 to C. To take into account the presence of noise, a ~2 statistics is added to the entropy measure. The objective function thus obtained is minimized using variational techniques and a conjugate-gradient iterative method. Some simulated results are given which compare this new method with the classical ones.
U.S. Teenage Pregnancies, Births and Abortions, 2010: National and State Trends by Age, Race and Ethnicity

Rates of teen pregnancy birth and abortion have declined dramatically in the United States since their peak in the early 1990s. In 2010 some 614000 pregnancies occurred among teenage women aged 15-19 for a rate of 57.4 pregnancies per 1000 women that age. This marks a 51% decline from the 1990 peak and a 15% decline in just two years from 67.8 in 2008 according to this new study by the Guttmacher Institute. Similarly the teen birthrate declined 44% from the peak in 1991 (from 61.8 births per 1000 to 34.4 per 1000); and the teen abortion rate declined 66% between its 1988 peak and 2010 (from 43.5 abortions per 1000 to 14.7 per 1000).
Games with informants: an information-theoretical approach towards a game-theoretical problem

The purpose of this paper is to investigate the influenc.e of information in non-coopera- tive games. We shall use methods being provided by information theory. The asymptotic value of a class of two-person zero-sum games is investigated in which one of the players is supplied with some knowledge of the controls chosen by the other. According to this information he then chooses his own controls. Due to this asymmetry a higher payoff arises compared to the outcome of games being played under the usual assumptions. The main result of this chapter is a computable formula for the value of these games.
Effects of Terrestrial Radiation on Integrated Circuits

As the dimensions and operating consumer’s insatiable demand for h tion, their sensitivity to radiation ha are responsible for a plethora of reli 31.1 Background—Motivation and Terminology 31-1 31.2 The Terrestrial Radiation Environment 31-2 Ions in Matter † High-Energy Cosmic Ray Neutrons † Alpha Particles from the Radioactive Decay of Impurities † Low-Energy Cosmic Ray Neutrons and B 31.3 Radiation Effects on Semiconductor Devices 31-10 31.4 Technology Scaling Trends 31-13 Memory SER Sensitivity † Sequential/Combinational Logic SER Sensitivity
Plaintext Simulatability

We propose a new security class, called plaintext simulatability, defined over the public-key encryption schemes. The notion of plaintext simulatability (denoted PS) is similar to the notion of plaintext awareness (denoted PA) defined in [3], but it is "properly" a weaker security class for public-key encryption. It is known that PA implies the class of CCA2-secure encryption (denoted IND-CCA2) but not vice versa. In most cases, PA is "unnecessarily" strong---In such cases, PA is only used to study that the public-key encryption scheme involved meets IND-CCA2, because it looks much easier to treat the membership of PA than to do "directly" the membership of IND-CCA2. We show that PS also implies IND-CCA2, while preserving such a technical advantage as well as PA. We present two novel CCA2-secure public-key encryption schemes, which should have been provided with more complicated security analyses. One is a random-oracle version of Dolev-Dwork-Naor's encryption scheme [9]. Unlike the original scheme, this construction is efficient. The other is a public-key encryption scheme based on a strong pseudo-random permutation family [16] which provides the optimal ciphertext lengths for verifying the validity of ciphertexts, i.e., (ciphertext size) = (message size) + (randomness size). According to [19], such a construction remains open. Both schemes meet PS but not PA.
Complete axiomatisations of weak-, delay- and η-bisimulation for Process algebras with Alternative quantification over data

Groote and Luttik (1998a) proved that the extension of the theory pCRL with the axioms for branching bisimulation of Van Glabbeek and Weijland (1996) yields a ground complete axiomatisation of branching bisimulation algebras with data, and conditionals and alternative quantification over these, provided that the data part has built-in equality and built-in Skolem functions. In this paper we shall use this result to obtain ground complete axiomatisations of η-bisimulation algebras, delay bisimulation algebras and weak bisimulation algebras with data, conditionals and alternative quantification over data, under the same proviso as before. 1991 Mathematics Subject Classification: 03G25; 08A70; 68Q65; 68Q70 1991 Computing Reviews Classification System: D.1. 3; F.1. 1; F.4. 1
Shift and width of the Hα line of hydrogen in dense plasmas

The profile and the shift of the H α line of hydrogen were measured and the shift was calculated at high electron densities in a helium plasma. The plasma has produced in a gas-liner pinch, which was diagnosed by Thomson scattering. Densities were between 1×10 18 cm -3 and 1×10 19 cm -3 and temperatures varied from 4 up to 12.5 eV. The results show a nonlinear behavior of the shift. Corresponding theoretical calculations have been performed, especially taking into account the dynamic screening of the electron-atom interaction. The agreement is very good for densities below 5×10 18 cm 3 ; above that density it is satisfactory
Ethnicity, Communication, and Drugs

This study explored the degree to which different patterns of communication media exposure are associated with attitudes and behaviors related to drug usage, across four main diverse ethnic groups in the U.S.: whites, blacks, Hispanics and Asians. It was expected that members of these different groups would exhibit diverse patterns of correlation between their media habits and their drug attitudes and behaviors. By means of a quota sample, 171 personal interviews were completed with 45 white, 42 Hispanic, 43 Asian, and 41 black respondents in the Bay Area of San Francisco in the Fall of 1986. Of particular importance was that television exposure, Rock exposure, print and interpersonal channels behaved differently across ethnic groups. The most striking differences occurred when examining the associations between exposure to specific television shows and attitudes towards drugs and adventurous experimentation. Black and white respondents exhibited sharp contrasts which deserve careful scrutiny and understanding.
Menopause and skin aging

The skin is one of the organs, which is influenced by sex steroids, especially estrogen and testosterone. Estrogen receptors are found in the whole skin, with the density of receptors being highest on the face, pubic region, genitalia and lower limbs. Pregnancy, menstruation and menopause modulate the skin appearance and properties, especially during menopause the skin undergoes profound changes. Postmenopausal women often complain of dry, atrophic, slack skin with increased wrinkling. The altered biomechanical properties of the skin in climacteric women cause certain disorders, such as atrophic vulvovaginitis, dysaesthetic vulvodynia, vulval lichen sclerosus, facial hirsutism, frontal fibrosing alopecia and recurrent menopausal flushing. Although skin aging is certainly no indication for the hormone replacement therapy the beneficial effect of estrogen supplementation on the skin appearance is a positive side aspect of such treatment.
A deep 38-MHz radio survey of the area delta >+60.

Un survey profond des radiosources a ete realise a une frequence de 38 MHz. Le survey couvre une aire d'environ 1 sr au nord de δ = +60° et contient les flux pour environ 5000 sources. Les methodes de reduction des donnees sont decrites et les traces des contours ainsi qu'une liste des sources pour toute l'aire etudiee sont presentes.
Whole ear allograft transplantation by immunologic induction of donor-specific tolerance by bone marrow transplantation

Objective Previous studies in our laboratory have demonstrated that application of donor bone marrow cells for central immune modulation will be beneficial for allograft tolerance induction in the rabbit model. Methods In this studies, based on the results obtained in the above model, for reducing the severity of the host conditioning, we treated groups in allograft with only intraosseous single injection of donor bone marrow cells. Results In comparison with our previous published data, the similar results as mean allograft survival time of (88.0±6.0) days were obtained. Todetermine whether the above results could be generalized, the ear transplantation was performed using this protocol. Ears allograft survivaltime of (146.0±15.1) days were obtained. One ear transplanted from the donor was accepted for more then 1 year without any clinical signs of rejection. Conclusion The data suggest that administration of only intraosseous injection of donor bone marrow cells without need for immunosuppressive agents was sufficient to allow induction of donor-specific tolerance in rabbit model without loss of effectiveness.
A Diagrammatic Calculus for Algebraic Effects

We introduce a new, diagrammatic notation for representing the result of algebraic effectful computations. Our notation explicitly separates the effects produced during a computation from the possible values returned, this way simplifying the extension of definitions and results on pure computations to an effectful setting. We give a formal foundation for our notation in terms of Lawvere theories and generic effects.
Human papilloma virus vaccines

Genital HPV infections are considered the most common sexually transmitted disease.HPV infection status predicts future progression of human squamous intraepithelial lesions(HSIL),and high-risk types of HPV are associated with precancerous and malignant lesions in anogenital region.Persistent HPV infection is a critical risk factor.The preventive vaccine aims to increase an immune response so as to limit or prevent infection and block clinical progression of the disease.While the therapeutic vaccine is suitable for those individuals in whom HPV infection has already occurred.In the developing countries,the people may benefit from of such safe and effective vaccines to prevent cervical cancer.Maybe,childhood vaccination is a better solution for the disease.
Radar Classification of Contiguous Activities of Daily Living

We consider radar classifications of Activities of Daily Living (ADL) which can prove beneficial in fall detection, analysis of daily routines, and discerning physical and cognitive human conditions. We focus on contiguous motion classifications which follow and commensurate with the human ethogram of possible motion sequences. Contiguous motions can be closely connected with no clear time gap separations. In the proposed motion classification approach, we utilize the Radon transform applied to the radar range-map to detect the translation motion, whereas an energy detector is used to provide the onset and offset times of in-place motions, such as sitting down and standing up. It is shown that motion classifications give different results when performed forward and backward in time. The number of classes, thereby classification rates, considered by a classifier, is made variable depending on the current motion state and the possible transitioning activities in and out of the state. Motion examples are provided to delineate the performance of the proposed approach under typical sequences of human motions.
CNNTOP: a CNN-based Trajectory Owner Prediction Method

Trajectory owner prediction is the basis for many applications such as personalized recommendation, urban planning. Although much effort has been put on this topic, the results archived are still not good enough. Existing methods mainly employ RNNs to model trajectories semantically due to the inherent sequential attribute of trajectories. However, these approaches are weak at Point of Interest (POI) representation learning and trajectory feature detection. Thus, the performance of existing solutions is far from the requirements of practical applications. In this paper, we propose a novel CNN-based Trajectory Owner Prediction (CNNTOP) method. Firstly, we connect all POI according to trajectories from all users. The result is a connected graph that can be used to generate more informative POI sequences than other approaches. Secondly, we employ the Node2Vec algorithm to encode each POI into a low-dimensional real value vector. Then, we transform each trajectory into a fixed-dimensional matrix, which is similar to an image. Finally, a CNN is designed to detect features and predict the owner of a given trajectory. The CNN can extract informative features from the matrix representations of trajectories by convolutional operations, Batch normalization, and $K$-max pooling operations. Extensive experiments on real datasets demonstrate that CNNTOP substantially outperforms existing solutions in terms of macro-Precision, macro-Recall, macro-F1, and accuracy.
THE SYNTACTIC SIGNATURE OF STARBUCKS ’ LOCATIONS Towards a machine-learning approach to location decision-making

The space syntax Theory of Natural Movement postulates that everything else being equal, land use selects their location based on the asymmetry of accessibility created by the configuration of the street network. In this article, I test the hypothesis whether configurational (syntactic) properties of an urban street network are relevant for the location of land use. If syntactic features are relevant, then land use types may have a ‘syntactic signature’. To identify this blueprint, I apply machine-learning techniques to datasets of syntactic measures, for ten business types. The results are ten models, each with the syntactic blueprint of a type of business. The models are used to predict the existence, or not, of such businesses in segments of the map of London. The performance of the models varies, with fifty per cent reaching statistical significance, including one with ‘good’ prediction ability. The models for Starbucks coffee shops and solicitor’s offices have the strongest prediction ability. The exploratory exercise demonstrates the potential of the machine-learning method Random Forests, when supervised and individually applied to a business activity, to identify the syntactic signature of business types. Such models can be used during planning and design and on location studies. The results strengthen the candidacy of syntactic measurements to location-decision-making. Moreover, they reinforce the theory of Natural Movement.
Sublinear Separators in Intersection Graphs of Convex Shapes

We give a natural sufficient condition for an intersection graph of compact convex sets in R^d to have a balanced separator of sublinear size. This condition generalizes several previous results on sublinear separators in intersection graphs. Furthermore, the argument used to prove the existence of sublinear separators is based on a connection with generalized coloring numbers which has not been previously explored in geometric settings.
Effect of Impulsive Noise on Uplink NOMA Systems

Non-orthogonal multiple access (NOMA) was recently proposed as a viable technology that can potentially provide the spectral efficiency, low latency, and massive connectivity requirements of future radio networks. In this context, numerous ultra-high reliability technologies such as the industrial Internet of things, smart grids, and smart homes present environments which are characterized by the presence of impulsive electromagnetic interference, known as impulsive noise. Under such conditions, the power domain multiplexing in NOMA is expected to render the system particularly sensitive to this additional impulsive noise. Therefore, in this article, we quantify the effects of impulsive noise on the outage performance of uplink NOMA systems. Extensive Monte-Carlo simulations as well as offered analytical results demonstrate the vulnerability of the involved NOMA users to this type of noise. This highlights the need for effective modeling of the impulsive noise as well as the design of mitigation techniques that are suitable for the particular demands and challenges of NOMA.
KYChain: user-controlled KYC data sharing and certification

Under Know Your Customer (KYC) regulations, financial institutions are required to verify the identity and assess the trustworthiness of any new client during on-boarding, and maintain up-to-date records for risk management. These processes are time consuming, expensive, typically have sub-par record-keeping steps, and disadvantage clients with nomad lifestyle. In this paper, we introduce KYChain as a privacy-preserving certification mechanism that allows users to share (certified) up-to-date KYC data across multiple financial institutions. We base KYChain on immutable ledgers and show that it offers confidentiality and certification compliance of KYC data.
Wall-modeled large-eddy simulation of non-equilibrium turbulent boundary layers

We conducted WMLES to examine the performance of a simple and widely used ODE-based equilibrium wall model in a spatially-developing 3D TBL inside a bent square duct (Schwarz and Bradshaw 1994) and 3D separated flows behind a skewed bump (Ching et al. 2018a,b; Ching and Eaton 2019). From the square duct simulation, the mean velocity profiles and crossflow angles in the outer region were predicted with high accuracy for all the considered mesh resolutions. Some disagreement was observed in the crossflow angles in the bend region where the non-equilibrium effect is most significant. Also, the simulation for the wall-mounted skewed bump showed that this simple ODE-based equilibrium wall model along with an adequate grid resolution around the 3D separation point resulted in reasonable predictions of 3D separating and reattaching flows, including mean velocity distributions, separation bubbles, and vortex structures in the bump wake.
Lensing efficiency for gravitational wave mergers

We gain insight into the effects of gravitational lensing on the estimated distribution of merging binaries observed through gravitational waves. We quantify the efficiency of magnification for gravitational wave events in the geometric optics limit, and we compare it to the electromagnetic case by making minimal assumptions about the distribution of intrinsic properties for the source population. We show that lensing effects leave a recognizable signature on the observed rates, and that they can be prominent only in the presence of an extremely steep mass function (or redshift evolution) and mainly at low inferred redshifts. We conclude that gravitational magnification does not represent a significant systematic for gravitational wave merger studies in the LIGO–Virgo era.