Miracle-dz/UniFAR-FTUs huggingface dataset:
Distributed Protein Sequence Alignment

Given the explosive growth of biological sequence databases and the computational complexity of aligning large sequences over extremely large databases most researchers have opted for utilizing the BLAST algorithm. While BLAST is completely appropriate for some purposes, the more rigorous and more computationally expensive Smith-Waterman algorithm is preferred for certain purposes. This work presents an implementation of the mathematically optimal SmithWaterman protein sequence alignment algorithm using a collection of distributed computers. We also present the use of the Unicon programming language as an alternative for writing biological search algorithms and other applications in bioinformatics rather than the most commonly found C or Perl approaches. The system has fault tolerant capabilities and can dynamically add and remove nodes to deal with worker node failure. The system currently operates on up to 87 P4 3.0 GHz machines. The system is called UDPS for Unicon Distributed Protein Searcher
Quantifying the importance of guessing, decision noise, and variable precision in explaining behavioral variability in visual perception

When presented with the same sensory stimuli and performing the same task, people do not always make the same response. Such behavioral variability can have different causes, including sensory noise, decision noise, and guessing. In addition, recent work has proposed that the precision of sensory encoding is itself variable, both driven by the stimulus (heteroskedasticity) and independent of the stimulus. We analyzed data of 3 published and 8 new visual decision-making tasks with a single relevant feature, orientation. In modeling each experiment, we considered four factors: guessing (lapses), decision noise, orientation-dependent variable precision (oblique effect), and orientation-independent variable precision (inspired by visual working memory models). Modern computational power allows us to test all combinations of these factors; in a given model, each factor could be present or absent. To quantify the importance of each factor in explaining the data, we introduce three metrics: factor knock-in, factor knock-out and factor posterior probability. Across all experiments, we found strong evidence for guessing and for orientation-dependent variable precision. We found evidence for decision noise in only one experiment, and for orientation-independent variable precision only when distractors are variable across trials. On a methodological note, the factor importance metrics can be applied widely in factorial model comparison.
Health Information Seeking Behaviour among Hypertensive Disorder In Pregnancy ( HDP ) High Risks Antenatal Mothers

Background: Provision of good maternal healthcare should be incorporated with early risks screening, given prompt management based on evidence-based medicine according to acceptable technological standard which is affordable at each appropriate level of care. Health education is delivered with aim to help its management process. Health information seeking behaviour of the antenatal mothers facing with risks should be examined to prevent antecedents for bad outcomes. This study aims to measure the prevalence of health information seeking behaviour among the hypertensive disorder in pregnancy (HDP) risk antenatal mothers and its influencing factors. Methods: A cross sectional study was conducted among antenatal mothers with HDP risks. Multistage random sampling technique was used to select respondents from health centres in one of the district that showed highest maternal death cases reported in Malaysia. Self-administered questionnaire covered the socio-demographic, health information seeking behaviour, health information seeking needs for HDP, barriers in health information seeking, coping style and self-efficacy were used. Results: There were 360 respondents with high risk HDP were screened from 2207 antenatal mothers attended at selected health centres. Result showed that the prevalence of antenatal mothers at risk for HDP was 16.31% (n=360). Prevalence of high risk antenatal for HDP with good health seeking information behaviours was only 51.1%. Higher household income (crude odds ratio 2.38, CI 1.51-3.74), having tertiary education (crude odds ratio 1.84, CI 1.21-2.81), no previous obstetric history, low barrier in health information search (crude odds ratio 2.44, CI 1.60-3.74), good monitoring behaviour (crude odds ratio 1.64, CI 1.052.54) and high self-efficacy (crude odds ratio 2.41, CI 1.58-3.68) have good health information seeking behaviour. However, respondents’ perception on health information needs related to HDP was found not significant. Multiple logistic regression showed that respondents with high income (>RM 2300) (adjusted odds ratio 2.12, CI 1.17-3.86), low health information seeking barrier (adjusted odds ratio 1.83, CI 1.14-2.94) and high self-efficacy (adjusted odds ratio 1.83, CI 1.14-2.92) had good health information seeking behaviour. Conclusion: Concerted effort to deliver relevant health information to HDP risk group should start as early in pre-pregnancy care to all reproductive women.
Escalated Oxidative Stress and Estrogen Level Stimulate Invasion of Tumor Cells in Infiltrating Ductal Carcinoma

Breast cancer (CaBr) accredits one of the highest numbers of deaths due to cancer in women on the planet. Severity of the breast cancer is dreaded, mostly due to its invasiveness and expedition of cancer progression. Since, infiltrating ductal carcinoma (IDC) is the commonest type of breast cancer and alone accounts for more than 80% occurrence as compared to other types of breast cancer which requires more focus. Oxidative stress has been implicated to play a pivotal role in cancer development. MDA is a byproduct of lipid peroxidation, a chain of reaction initiated by reactive oxygen species (ROS) leading to death of cells. Estrogen has been reported to be causative agent of cancers of epithelial origin including IDC, mullerian epithelial ovarian cancer etc. Thus, MDA and estrogen levels have been selected as biomarker for IDC. MDA assessment in serum and tissue was performed according to standard protocol. RBC count and haemoglobin level were measured by standard protocol. Estimation of estrogen was performed by ELISA. MDA level in serum of CaBr patients was found to be higher than normal persons with postmenopausal CaBr patients having highest level (p<0.0001) and similar fashioned graph was established while analyzing MDA in tissue with p<0.0493. RBC count was observed to be lower in both premenopausal and postmenopausal CaBr patients than normal person, Haemoglobin level also shows similar level as RBC. It can be concluded that oxidative stress devastate the cells structure and estrogen enhances proliferation which induces the invasion of epithelial cells into stromal cells of breast and begins the formation of IDC.
Quantification of angiogenic characteristics of Naproxen sodium through chorioallantoic membrane assay

Introduction: The aim of the current study was to determine the angiogenic/anti-angiogenic effect of Naproxen Sodium and to determine the effective dose of NapS for angiogenesis. Method: Fertilized eggs (5days old) of chicken were acquired from a local hatchery. They were incubated at 37oC with humidity of 55-60%. Then, on the 5th day of incubation, a window about 2cm in diameter was created by removing the shell and then the inner shell membrane. It was done under aseptic environment. There were 5 groups designed. Group A was kept as control and was given 0.2ml PBS, group B, C, D, and E were given 0.1ml of 0.086g/100μl, 0.042g/100μl, 0.021g/100μl and 0.011g/100μl of Naproxen Sodium (NapS) respectively. On the sixth day, prepared concentrations of NapS were administered and eggs were again sealed with paraffin film under aseptic conditions. These were placed back in the incubator for next 24 hours. After 24 hours, eggs were taken out from the incubator and images of all groups were made using a DSL camera. The development of blood vessels and other features were observed using Adobe Photoshop version 7.0, then these images were transferred to scan probing image processing (SPIP) software 6.6. 2. The diameters of different blood vessels were measured by using expert design software. The parameters include: the diameter and branching system of blood vessels measured as per mm, and categories of blood vessels; i.e., primary, secondary and tertiary blood vessels. Data were analyzed on SPSS statistical software version 22.0 using ANOVA. Dunnett’s test was applied considering P < 0.05 as significant. Result: Application of Naproxen sodium on chorioallantoic membrane of day six of incubation showed angiogenic effects in high concentration and anti-angiogenic effect in low concentration. Outcomes indicated significant changes in CAM’s design, thinning of primary, secondary and tertiary blood vessels, reduction in surface roughness parameters, and decrease in Abbott curve. Conclusion: The substantial quantities of Naproxen sodium use locally may exhibit anti-angiogenic activity in the same manner those seen in vitro and explain its clinical efficacy.
Etudes sur l'association des mots

Resume Afin d'eprouver la generalite de quelques conclusions etendues sur le role de l'association de mots dans le comportement linguistique, ces conclusions etant tirees d'experiences faites uniquement en anglais, nous avons fait des etudes sur l'association en francais. Nous avons determine d'abord les normes des reponses associatives, utilisant une adaptation francaise du test de Kent et Rosanoff. En general, les reponses se sont montrees assez semblables dans les deux langues. Ensuite, nous avons repete l'experience de Jenkins et Russell sur le groupement associatif dans le rappel. Dans cette experience, les sujets ont ecoute une liste de mots en essayant de se rappeler autant de mots que possible. La liste se composait de vingt-quatre paires de stimuli et reponses primaires, choisies dans le test d'association ; l'ordre des mots etait determine au hasard. La consigne etait de se rappeler autant de mots que possible et de les ecrire dans l'ordre dans lequel ils venaient sans respecter celui dans lequel ils etaient dits. Sur quatre hypotheses sur les influences de l'association sur le rappel, trois ont ete verifiees. Nos resultats sont d'accord avec les resultats des experiences americaines.
A Viewpoint on : Aspiration of Biological Viscoelastic Drops

It is widely accepted by now that the mechanical characteristics of cells and tissues play an important role in numerous biological processes, such as early morphogenesis [1, 2], signal transduction [3], cell adhesion [4], and even stem cell differentiation [5, 6]. In particular, it was suggested and experimentally demonstrated that a number of phenomena in embryonic tissues can be interpreted through their viscoelastic properties [7]. Tissue mechanical properties have often been quantified by measurements using spherical aggregates of cells (as models of tissues) and parallel-plate tensiometry [8]. In this technique the aggregates are exposed to a fixed strain by compression between the plates and the viscoelastic parameters such as surface tension (γ), elastic constant (E), and viscosity (η) are determined from the relaxation of the compressive force (i.e., stress) to equilibrium. In a work published in Physical Review Letters[9], Karine Guevorkian and collaborators from CNRS-Institut Curie and Ecole Polytechnique, both in France, and McMaster University, Canada, use, for the first time, micropipette aspiration—a method normally applied to individual cells—to test the mechanical behavior of multicellular spheroids and to determine γ, E, and η.
Sanitation and Hygiene: Policy, Stated Beliefs and Actual Practice: A Case Study in the Burera District, Rwanda

This case study compares policy and practice on sanitation and hygiene in Rwanda, where these issues are government priorities, and a range of guidelines and standards are prescribed for toilet technologies.The paper looks specifically at the guidelines and standards for urine diversion dry toilets (UDDTs), as well as those on the use of treated human excreta as fertilizer, and on pit latrines (“drop and store”). It then describes how these guidelines and standards are enforced at the community level – specifically in the Rugarama sector, Burera District, one of four Rwandan districts where the United Nations Children’s Fund (UNICEF) is carrying out a water, sanitation and hygiene (WASH) programme.The paper presents the prevailing sanitation and hygiene norms and practices and, using qualitative research methods, evaluates how and why they differ from the prescribed guidelines and standards. In fact, the study shows, health, hygiene, convenience, and safety aspects of sanitation in the study area remain unsatisfactory.Most of the toilets in these communities are neither properly constructed nor properly used. Reasons for the contradictions between prevailing practice and national guidelines and standards include the following: people do not place a high priority on toilets; financial constraints limit household investment in toilets; there is a lack of proper understanding of prescribed sanitation and hygiene guidelines and standards; and there are challenges in carrying out sanitary inspections.For the productive sanitation system in particular, poor understanding of how the system works was identified as the main cause of the mismatch between standards and practice. This study posits that a common understanding of prescribed guidelines and standards at all levels of society is vital to ensure health and safety, improved livelihoods, and to maintain minimum hygiene and sanitation standards.Furthermore, improved understanding of the importance of having properly constructed and well maintained sanitation and hygiene facilities will, undoubtedly, create a demand for such facilities irrespective of the economic hindrances reported by most community members.
8. Estudo complementar: abordagem geoarqueológica ao EP 1035 - Quinta dos Barrais

 Procurássemos clarificar a funcionalidade e a cronologia dos “montículos” de pedras e das estruturas pétreas de planta circular identificados no local;  Verificássemos a relação entre as estruturas circulares e o canal de drenagem que lhes subjaz;  Caracterizássemos o terraço fluvial do ponto de vista morfo-sedimentar;  Avaliássemos o seu potencial arqueológico e mineral;  Estabelecêssemos a natureza da alteração morfológica da plataforma onde se implanta o sítio arqueológico.
Honorários de Auditoria: Análise Comparativa em Empresas Listadas na BM&FBOVESPA

Com a adocao da pratica de governanca corporativa, as empresas conseguem emitir sinais aos usuarios externos com confiabilidade sobre suas informacoes. De acordo com a teoria da sinalizacao, as praticas e mecanismos de governanca corporativa, e a forma de a empresa representar sinais que estao se comunicando com o mercado. Neste contexto, este artigo apresenta o estudo realizado em verificar se ha relacao entre os niveis de governanca corporativa e os honorarios de auditoria contabil das empresas listadas na BM&FBovespa. A pesquisa analisou uma amostra de 169 empresas referente ao ano de 2015 por meio da analise de estatistica descritiva e a tecnica econometrica de regressao linear multipla. A pesquisa e descritiva, documental e com analise quantitativa. Foram utilizadas como hipotese de pesquisa as seguintes variaveis: governanca corporativa (GovCorp), firma de auditoria (Big4), tamanho da empresa (Tam), complexidade (Subs), retorno sobre o ativo (ROA), alavancagem financeira (Alav), contas a receber (CtasRec) e estoque (Est) abordando a relacao a entre a variavel dependente honorarios de auditoria (HonAud). Os resultados demonstraram que apenas as variaveis Big4, Tam e Alav possuem relacao positiva e significativa com os honorarios de auditoria. Portanto, rejeita-se a hipotese principal do estudo, pois nao foi constatada relacao positiva e significativa entre os niveis de Governanca Corporativa e os honorarios de auditoria contabil.
Combined, Minimally Invasive, Thread-based Facelift

Aging is a natural, biological process. Patients want to overcome the aesthetic problems associated with facial aging. Plastic surgeons have tried facelifts to meet patients’ expectations [1,2]. With the development of society and technology, patients prefer simple, less-invasive procedures for rapid recovery. A barbed suture lift can meet the requirement for a minimally invasive facial rejuvenation procedure. Former thread lifts have used either a floating or fixed type thread [1]. But when we consider the functional anatomy of the face in terms of facial expressions and mastication, and a natural looking appearance after surgery, a floating-type thread lift is preferred for the mobile area of the face and a fixed-type thread lift is recom-mended for use in relatively fixed areas. The authors call this meth -od the combined-type thread lift. The authors have performed this type of facelift in 28 patients with satisfactory results.
Orientación al Mercado en las Pequeñas Empresas del Sector Calzado en Cuero de la Ciudad de Bogotá

Considerando las dificultades que tienen las Pequenas Empresas que se dedican a producir calzado en cuero en Bogota, relacionadas con los bajos niveles de productividad y ventas, la falta de innovacion y acciones de mercadeo que hacen que se cierren y desaparezcan del mercado, la presente investigacion se propone analizar los mecanismos por medio de los cuales se implementan las acciones de Orientacion al Mercado en este sector, por cuanto se considera una estrategia que permite garantizar la satisfaccion y gustos del cliente y la sostenibilidad y crecimiento de la empresa
EFEITOS PSICOFISIOLÓGICOS DO EXERCÍCIO FÍSICO EM PACIENTES COM TRANSTORNOS DE ANSIEDADE E DEPRESSÃO

O ser humano esta sujeito desde sua concepcao, a diversas e complicadas transformacoes, amplamente relacionadas aos aspectos fisicos, ambientais, sociais, psicologicos e aos habitos de atividades do dia a dia. Tais transformacoes podem levar a varias doencas, dentre elas, atualmente destacam-se os transtornos de ansiedade e depressao. A pratica da atividade fisica sistematica vem sendo tema de varios trabalhos tendo como foco, a possivel eficacia na melhoria de seus sintomas e causas. O presente artigo teve como objetivo revisar estudos dos ultimos 10 anos sobre o efeito do exercicio fisico no comportamento de pessoas com os transtornos de ansiedade e depressao, bem como, entender os mecanismos neurofisiologicos causadores de tais doencas, seus fatores psicofisiologicos e psicossociais. Com bases nos artigos pesquisados observa-se que a pratica de exercicios fisicos constitui importante via terapeutica no tratamento de transtornos de ansiedade e depressao, alem de propiciar melhoras significativas em outros parâmetros fisiologicos.
Performance comparison of gain-coupled and index-coupled DFB semiconductor lasers

Comprehensive numerical simulations with the transmission-line laser model (TLLM) are used to compare the behavior of gain-coupled DFB lasers with index-coupled DFB lasers fabricated from identical materials. These simulations compare slope efficiency, threshold current, spectra, small-signal modulation bandwidth, maximum-intrinsic modulation bandwidth, large-signal transient response and chirp, relative-intensity-noise (RIN) spectra, and feedback sensitivity for coherence collapse. In most cases gain-coupled lasers with additional index coupling have better performance than index-coupled lasers for a given material. However, high-coupling factor index-coupled lasers do have lower threshold currents, lower RIN levels, and lower sensitivity to external feedback than gain-coupled lasers, although spatial hole burning in these devices can be disadvantageous. >
Lennox Legacy: The History of the CSIRO Laboratory at 343 Royal Parade Parkville

The Lennox Legacy: The history of the CSIRO Laboratory at 343 Royal Parade Parkville records many of the events and incidents associated with the genesis and development of the Division of Protein Chemistry over a period of more than fifty years. This book has been titled in honour of Dr Francis Gordon Lennox, the Laboratory's founder and a man who believed that science has an important part to play in bettering the well-being of all Australians. His vision, over the years, of the critical importance of protein chemistry to Australian science and industry, was central to the Laboratory's national and international achievements. The book has been written three parts: *Part 1 attempts to trace the historical record of appointments and changes in research direction that have occurred in the laboratory from 1940 to the present day. *Part 2 presents a more detailed description of the major scientific activities that have been carried out in the Laboratory. It reveals how fundamental studies went hand-in-hand with applied research and thereby contributed greatly to the understanding of practical problems and their possible solution. *Part 3 provides a complete list of Patents and Publications arranged in decades for easy perusal. As former chief Gordon Crewther states in his foreword: "Of necessity, the story is incomplete, but because it records the stresses, exhilarations, frustrations, rewards, good fellowship, team spirit, irritations and humourous interludes arising from the research objectives of the Division and their accomplishment, there is something of interest for all present and past members of staff of CSIRO. The less technical sections, the occasional insights into/behind the scenes' activities, the glimpses of individual personalities, and the occasional reflections on science management, provides worthwhile reading for a more general audience. "
An Intelligent Diagnostic System for Lung Cancer based on Principle Component Analysis-Wavelet Support Vector Machines Classifiers

D. A. Author is with the Electric and Electronic Engineering, Firat State University, 23119 TURKEY (e-mail:derya2344@hotmail.com). Abstract—in this study, an intelligent diagnosis system for lung cancer on Principle Component Analysis and Wavelet Support Vector Machine Classifier is presented. The structure of this intelligent system for diagnosis of lung cancer is composed by three phases: The attribute extraction and attribute reduction phase by using Principle Component Analysis method, classification phase by using Wavelet Support Vector Machine classifier phase, and the evaluation phase of this intelligent diagnosis system performance by using classification accuracy. In first phase, lung cancer dataset is obtained and dimension of this lung cancer dataset that has 24 attributes, is reduced to 10 attributes using Principle Component Analysis method. Then, in classification stage, these reduced attributes are given to Wavelet Support Vector Machine classifier. Finally, in third phase, the correct diagnosis performance of this intelligent system for diagnosis of lung cancer is calculated by using classification accuracy. The classification accuracy of this system was obtained about 91.66 % from results of these experimental studies.
Hungarian idioms in the predicative adverbial participle construction

The aim of this paper is to investigate the occurrence of Hungarian V+NP idioms in predicative adverbial participle constructions. The study is based on the cognitive treatment of idioms, which claims that only analyzable expressions allow the various syntactic variations. To test this hypothesis, I collected 100 Hungarian idioms and examined them with respect to their analyzability. Then I made a grammaticality judgement test in which the investigated idioms were put into the lett+V+-va/ve construction. The respondents of the test had to decide whether the expressions are grammatical or not in the given contexts. This paper reports the results of this investigation.