Miracle-dz/UniFAR-FTUs huggingface dataset:
Analytical Field Calculation and Analysis of Surface Inset Permanent Magnet Machines With High Saliency Ratio

In this paper, an analytical field calculation model is built for surface inset permanent magnet (SIPM) machines with high saliency ratio. The high saliency ratio of SIPM machine is obtained using unequal d-q axis air-gap length based on the SIPM rotor structure. High saliency ratio can produce large reluctance torque and wide speed range. To get a fast and exact knowledge of flux distribution and operation parameters of the SIPM machine with high saliency ratio, the field solving domain is divided into five subdomains, i.e., stator slots, stator slot openings, air-gap, rotor air slots, and rotor magnets. The vector potential in each subdomain is governed by Maxwell's equation and can be solved using the variable separation method and boundary conditions between adjacent subdomains. In addition, the cogging torque, back electromotive force (EMF), inductance, output torque, and unbalanced magnetic force (UMF) are calculated based on the field model. All the field calculation results are compared with those of finite element analysis (FEA), and it is shown that analytical field calculation model is fast and accurate. Furthermore, the effects of q -axis air-gap length and pole arc ratio on machine parameters, such as cogging torque, back EMF, saliency ratio, output torque, and UMF, are also investigated using the analytical field calculation model.
Comparison of Multiple Weighted Hierarchies: Visual Analytics for Microbe Community Profiling

We propose visual analytics techniques to support concurrent comparison of hundreds of cumulatively weighted instances of a single hierarchy. This includes a node‐link representation of the hierarchy where nodes depict the weights of all instances with high‐density heat maps that are grouped and aligned to ease cross‐referencing. Hierarchy exploration is facilitated by smoothly animated expansion and collapse of its branches. Detailed information about hierarchy structure, weights, and meta‐data is provided by secondary linked visualizations. These techniques have been implemented in a prototype tool, in which the computational analysis concerns have been strictly separated from the visualization concerns. The analysis algorithms are extensible via a script engine. We discuss the effectiveness of our techniques for the visual analytic process of microbe community profiling experts.
Anaphylatoxin-mediated regulation of the immune response. I. C3a- mediated suppression of human and murine humoral immune responses

The C3a fragment of the third component of complement was found to have immunosuppressive properties. C3a is capable of suppressing both specific and polyclonal antibody responses. In contrast, C3a had no effect on antigen- or mitogen-induced B or T cell proliferative responses. The carboxy-terminal arginine is essential for C3a to exhibit its immunosuppressive properties. The serum carboxypeptidase inhibitor 2-mercaptomethyl-5-guanodinopentanoic acid, which prevents cleavage of the terminal arginine that would produce C3ades Arg-77, allowed us to assay the effects of C3a on in vitro immune response systems where serum is required. When the terminal arginine is removed from C3a, the resulting C3ades Arg-77 molecule is nonsuppressive. Helper T lymphocytes are the target of C3a-mediated suppression of the immune response. Substitution of T cells by soluble T cell factors was found to abrogate the C3a suppressive activity.
Sustained Strain Monitor for Air Vehicle Structures

Next generation air vehicles will need thousands of sensors to simplify diagnostics and to detect problems before they cause catastrophic failures. Self-sustained wireless sensors would allow attaching them to hard to reach places, eliminating wiring, and improving the reliability of the system. In this paper, the power generation capability of piezoelectric elements is evaluated to determine how effectively they can provide the necessary electricity for self-sustained sensors. A three-step process is proposed for the selection of location and hardware. The steps include the evaluation of strain variation using ANSYS, the attachment of proper number of piezoelectric elements, and the use of microprocessors with minimal power consumption.
Effects of Chronic Therapy with Cardiac Contractility Modulation Electrical Signals on Cytoskeletal Proteins and Matrix Metalloproteinases in Dogs with Heart Failure

Objectives: Therapy with cardiac contractility modulation (CCM) electrical signals delivered to left ventricular (LV) muscle during the absolute refractory period improves LV systolic and diastolic function in dogs with heart failure (HF). This study examined the effects of CCM therapy on mRNA and protein expression of cytoskeletal proteins, matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) in the LV myocardium of dogs with HF. Methods: HF was produced in 14 dogs by coronary microembolizations. Dogs were randomized to 3 months of CCM therapy (n = 7) or to sham-operated controls (n = 7). LV tissue from 6 normal (NL) dogs was used for comparison. mRNA expression was measured using reverse-transcriptase polymerase chain reaction and protein expression using Western blots. Results: Compared with NL dogs, controls showed upregulation of mRNA and protein expression of the cytoskeletal proteins tubulin and fibronectin and MMP-1, MMP-2 and MMP-9, and downregulation of the cytoskeletal protein titin. Normalized expression of all these genes and proteins was seen after CCM therapy. No differences in expression of TIMP-1 and TIMP-2 were observed among groups. Conclusions: CCM therapy normalizes expression of key cytoskeletal proteins and MMPs and may partly explain the improvement in LV function seen in HF following CCM therapy.
Mode of Safener Action of Dimepiperate, a Thiolcarbamate Herbicide, on Bensulfuron Methyl Activity

Abstract Bensulfuron methyl is a sulfonylurea herbicide controlling a broad spectrum of broadleaf and sedge weeds in paddy rice. Safening effects with certain thiolcarbamate herbicides for grass control have been discovered in the process of combination products development. The results of mode of safening studies revealed that the enhancement of metabolic inactivation rate of bensulfuron methyl in plants was the basis of safening. Among these thiolcarbamates, dimepiperate was unique in exhibiting safening action even in direct water-seeded rice. Further studies on dimepiperate effects on root-applied bensulfuron methyl indicated that rice root elongation, enhanced metabolism in roots and in shoots, were the key to the safening effects. The translocation rate of bensulfuron methyl, from roots to shoots, on the other hand, was not significantly affected by dimepiperate.
Recurrent multiple cranial neuropathies in a diabetic patient.

PURPOSE Multiple cranial neuropathies is one of the neurological complications among diabetic patients. Symptoms of multiple cranial neuropathies may cause great anxiety for these patients and often appear to be a serious problem from a diagnostic and therapeutic point of view. A correct and timely diagnosis of the underlying cause of cranial nerve palsy in these patients is crucial because of the realistic threat of devastating neurologic conditions. CASE REPORT Recurrent cranial neuropathies involving different cranial nerves are unusual. In this case report, we present a diabetic patient with four episodes of recurrent cranial neuropathies including two times of facial neuropathies and two episodes of external ophthalmoplegia within 2 years. CONCLUSION Diabetic cranial neuropathies may appear in a recurrent pattern; spontaneous remission is the rule.
İlişkisel Pazarlamada Güven Unsuru ve Otel İşletmelerinde Uygulama

Bu calismanin birincil amaci musteri guveni ile musteri guvenini etkileyen faktorler arasindaki iliskiyi incelemektir. Ikincil amaclar, otel isletmelerinde musteri guvenini etkileyen boyutlari ortaya cikarmak ve bu boyutlarin musteri guveni uzerindeki etkilerini incelemektir. Bu amacla arastirmada iliskisel pazarlamanin tanimi, iliskisel pazarlamada guvenin tanimi ve yeri, ayrica otel isletmelerinde guvenin onemine yer verilmistir. Ote yandan arastirmada guveni etkileyen faktorler incelenerek model ve hipotezler kurulmus ve otel isletmelerindeki musterilerin otele karsi besledikleri guven ve bu guven uzerinde etkili olan boyutlar arasindaki iliski coklu regresyon modeli kullanilarak ampirik bicimde ele alinmistir. Calismanin baslica bulgusu soyledir; musteri guvenini etkileyen boyutlar somut varliklar, guven asilama, tavsiye edilebilirlik, heveslilik, ambiyans ve empatidir. Bu boyutlarin tumu musteri guvenindeki degisimlerin yaklasik % 71’ini aciklamaktadir. Dolayisiyla bu alti boyutun gelistirilmesi otel isletmeleri icin daha fazla musteri guveni yaratmak anlamina gelebilir
Computer-aided analysis of electronic circuits: Algorithms and computational techniques

Preparing the books to read every day is enjoyable for many people. However, there are still many people who also don't like reading. This is a problem. But, when you can support others to start reading, it will be better. One of the books that can be recommended for new readers is computer aided analysis of electronic circuits algorithms and computational techniques. This book is not kind of difficult book to read. It can be read and understand by the new readers.
Exotoxin‐insensitive G proteins mediate synaptically evoked muscarinic sodium current in rabbit sympathetic neurones.

1. The involvement of G proteins in the transduction pathway that links muscarinic receptors to the low‐threshold voltage‐dependent sodium current (INa,M) was studied in neurones from intact sympathetic prevertebral ganglia using the whole‐cell configuration of the patch‐clamp technique. Experiments were performed in the presence of the nicotinic receptor antagonists hexamethonium (50 microM) and d‐tubocurarine (50 microM). 2. INa,M was activated by either bath‐applying muscarinic agonists or stimulating the preganglionic splanchnic nerves. Synaptically and agonist‐mediated INa,M did not display significant run‐down or changes in their properties in cells tested, irrespective of whether the pipette solutions contained GTP. 3. Dialysis of sympathetic neurones with GDP beta S (500‐750 microM) decreased the amplitude of INa,M by approximately 65% compared with control neurones within 30 min. 4. In the absence of muscarinic receptor stimulation, intracellular dialysis with GTP gamma S (500 microM) for 10 min slowly and slightly (20‐25%) activated INa,M. GTP gamma S dialysis markedly slowed down the decay of INa,M after its transient activation with carbachol pulses (10‐20 s) or nerve stimulation (3‐5 s). The INa,M activation became fully irreversible 2.9 min after the start of GTP gamma S dialysis. Dialysing cells with the G protein activator AIF4‐led to a rapid but transient activation of INa,M. 5. Synaptically and agonist‐evoked INa,M were not affected in ganglia treated with 0.5‐1 microgram ml‐1 pertussis toxin (PTX) for 7‐24 h at 37 degrees C. Control experiments showed that this treatment severely reduced the PTX‐sensitive inhibition of N‐type calcium currents induced by carbachol (CCh) and noradrenaline. Application of NEM (N‐ethylmaleimide) for 2 min depressed the INa,M evoked in response to bath‐applied CCh by only 27%. 6. Incubating ganglia with 5‐10 micrograms ml‐1 of cholera toxin for 7 h had no effect on the carbachol‐induced INa,M but greatly potentiated (approximately 250%) the synaptically evoked INa,M, presumably via a presynaptic mechanism. 7. These results show that the coupling between muscarinic receptors and NaM channels is mediated by pertussis toxin‐ and cholera toxin‐insensitive G proteins, possibly of the Gq/11 or G12 class.
Pulmonary neuroendocrine/carcinoid tumors

Neuroendocrine tumors are a unique malignant neoplasm that can arise from the respiratory tree. Although well‐differentiated bronchial neuroendocrine tumors (also called carcinoid tumors) are reported to account for approximately 25% of all neuroendocrine tumors, they represent only 1% to 2% of all lung cancers. The epidemiology, clinical behavior, and treatment of neuroendocrine carcinoid tumors differ significantly from other lung malignancies. In this article, the recent data regarding these tumors were reviewed with attention to the treatment modalities used. Although conventional cytotoxic therapy has not been reported to demonstrate much promise in this entity over the past 4 decades, newer molecular targeted agents including those that targeted angiogenesis and the mammalian target of rapamycin (mTOR) pathway have shown encouraging results in early phase trials for advanced carcinoid tumors. Cancer 2009. © 2009 American Cancer Society.
Using Conceptual Models in Research Methods Courses: An experience using iStar 2.0

Conceptual modelling languages are typically taught in graduate and postgraduate information systems programs. In the specific case of postgraduate information systems students, the lecturer has the opportunity to exploit conceptual modelling for educational purposes that go beyond learning how to apply the modelling paradigm or specific languages. In this paper, we report on our employment of the recently proposed iStar 2.0 in the master-level course Advanced Research Methods at Utrecht University in the Netherlands. During this course, the students conducted a design science project where iStar 2.0 artefacts are evaluated in an experimental setting. We present the course (intended learning objectives, learning materials, etc.), we explain how we employed iStar 2.0 therein, and we discuss our teaching experience including lessons learnt.
Automatic Test Data Generation using Metaheuristic Cuckoo Search Algorithm

The proposed work emphasizes on the automated process of test data generation for unit testing of structured programs, targeting complete path coverage of the software under test. In recent years, Cuckoo Search CS has been successfully applied in many engineering applications because of its high convergence rate to the global solution. The authors motivated with the performance of Cuckoo search, utilized it to generate test suits for the standard benchmark problems, covering entire search space of the input data in less iterations. The experimental results reveal that the proposed approach covers entire search space generating test data for all feasible paths of the problem in few number of generations. It is observed that proposed approach gives promising results and outperforms other reported algorithms and it can be an alternative approach in the field of test data generation.
Defect detection and recognition of bare PCB based on computer vision

Defect detection and recognition of bare PCB plays a significant role in computer vision applications. An accurate and efficient approach is implemented in this paper. The approach is based on the comparison between the standard PCB image and the target image. Multiple images of the qualified PCBs are acquired at the same position. We take an average of the images and consider it to be an initial standard image. The paper suggests the concept of dynamic updation which means we update the standard image during the detection process. The bilateral filtering method is used in the preprocessing phase. Then the target image is compared with the standard image to get the difference image. And a suitable threshold is obtained by analyzing the histogram of the difference image to distinguish potential defect regions. Using the boundary-length-range method, the authenticity of each potential defect region is preliminarily judged. After that, we can identify the bare PCBs which have no defect. Moreover, an improved region growing method is proposed to obtain the complete ranges of the real defect regions. Finally, a simple but effective method is presented to recognize the type of the defects. Experimental results show that the proposed method in this paper works well.
Survival Analysis of Criminal Recidivism of Boot Camp Graduates Using Elements From General and Developmental Explanatory Models

This is a 5-year follow-up study of recidivism among 601 male graduates of a boot camp for adults in a southern state. Cox’s proportional hazard analysis is used to determine the hazard rate of recidivism (arrest or parole violation) of several elements of general and developmental models. Analyses are conducted according to age of onset of unlawful behavior (10 years old or younger and older than 10 years). Findings indicate that caregiving factors have inverse relations with the hazard of recidivism, whereas low self-control, deficits in social skills, peer association with criminals, gang membership, drug use and sales, and carrying weapons have positive relationships with this hazard. These findings are observed irrespective of the age when persons begin committing offenses. Implications of the findings for theoretical models is discussed.
The Effects of Internal Audit Quality and Earnings Management Option Complexity on Managerial Discretion in Financial Reporting

This study examines the effects of internal audit function (IAF) quality (comprised of competence and independence) and the comparative complexity of earnings management options on managerial discretion. In a 2x2x2 between-subjects experiment, 213 corporate managers assess whether and to what extent they would adjust an accounting estimate, cash-based expenditure, or both to achieve a specific earnings target. I predict and find that higher IAF quality lowers the likelihood of both types of earnings management. I also predict and find, however, that comparative complexity mediates this relationship such that managers tradeoff between the two options when the cash-based expenditure option is comparable in complexity to (more complex than) the accounting estimate option and IAF quality is high. This study contributes to knowledge by helping to further examine factors that explain and link IAF quality and managerial discretion in financial reporting and should be of interest to internal and external firm stakeholders.
Stereoacuity levles and vision problems in children from 7 to 11 years

A longitudinal study of stereoacuity levels of 859 children at 7 years, 811 children at 9 years and 796 children at 11 years was conducted using the TNO random dot stereotest. The prevalence of defective stereoscopic vision was found to be between 2.1 and 3.2 per cent. A further 10–16 per cent of children had only moderate stereoacuity levels when compared with their peers. The stereoacuity levels achieved by most of the children improved with age, but the rand order correlations for the stereoacuity levels between ages 7 and 9, and ages 9 and 11, were small. Defective stereopsis and poor stereoacuity levels were clearly associated with manifest strabismus and problems of visual acuity, and if failure to pass the quantitative plates was a cut‐off point for screening purposes most of the children with visual problems would have been identifies.
Discrimination and identification of voicing and place contrasts in aphasic patients.

Aphasic patients and controls were given discrimination and identification tasks using synthesized stop‐initial CV syllables. Three different seven‐step continua were used as stimuli: voicing (bee‐pea); place (bee‐dee); and vowel (bee‐bow). All subjects were given both tasks for each continuum. The aphasic patients were devided into a good and a moderate comprehension group on the basis of their scores on an auditory language comprehension test. In comparison to the controls, aphasics with moderate comprehension had difficulty perceiving voicing and place contrasts, while aphasics with good comprehension generally had difficulty with place contrasts only. There were no group differences on the vowel tasks. The majority of the subjects either discriminated and identified the stimuli, did not discriminate or identify the stimuli, or discriminated but did not identify the stimuli. A small number of subjects could not discriminate but could identify the stimuli, mainly on the voicing continuum.
Phase II trial of sorafenib in esophageal (E) and gastroesophageal junction (GEJ) cancer: Response observed in adenocarcinoma.

41 Background: Sorafenib is a tyrosine kinase inhibitor targeting VEGFr, PDGFr, Raf and other pathways. Encouraging response and survival were observed in a phase II trial combining sorafenib with chemotherapy in GE cancer (J Clin Oncol 27:2947;2010). We are studying single agent sorafenib in a phase II trial with the primary endpoint to assess progression free survival (PFS). Secondary endpoints include response and therapy tolerance. METHODS Patients (pts) with measurable metastatic E and GEJ cancer with no more than 3 prior chemotherapy regimens were treated with sorafenib 400 mg BID. CT scans were performed monthly for the first 2 months, then every 2 months. RESULTS Sixteen of 35 pts have been accrued and 14 are currently evaluable. 13 male, 3 female, median KPS 80%, age 58, GEJ 7, E 9, squamous 2, adenocarcinoma (AC)14. An ongoing complete response (11+ months) was observed in a pt with biopsy proven metastatic neck lymphadenopathy (E primary AC, recurrence after prior chemoradiotherapy and surgery). A second pt (GEJ AC) had protracted stable disease in bulky celiac node disease (15+ months). Grade 3 toxicity was limited to skin rash (1 pt), hand foot reaction (1 pt), and fatigue (1 pt). Only 3 of 14 pts (21%) had early disease progression at 2 months or less. Median PFS 4 mos, 4 patients (29%) continue on therapy for more than 7 months. The majority of tumors tested positive for phospho-erk by immunohistochemistry (11/14, 79%). CONCLUSIONS The observation of a durable complete response and protracted stable disease to sorafenib in E cancer is remarkable. Further accrual continues to define PFS. Supported by a grant from Bayer. [Table: see text].
Quantitation of bacteria in cerebrospinal fluid and blood of children with meningitis and its diagnostic significance

Cerebrospinal fluid (CSF) specimens from pediatric patients with meningitis were examined for their concentration of microbes and the relationship of this count to the bacteremia levels, microscopy results, and polymorphonuclear leukocyte concentration. A total of 2,031 consecutive CSF specimens were analyzed, of which 63 (3.1%) were positive by culture from the same number of patients. We observed that 85% of the total CSF specimens positive for Haemophilus influenzae type b, Streptococcus agalactiae, Streptococcus pneumoniae, and Neisseria meningitidis had counts in excess of 10(3) CFU/ml, with 56% of the specimens exceeding 10(5) CFU/ml. A correlation existed between the number of organisms present in the CSF and blood. For example, from a total of 22 patients who had counts of H. influenzae greater than 10(3) CFU/ml in the CSF, 16 or 73% had levels of bacteremia greater than 10(3) CFU/ml. It was also noted that the bacterial concentration had a profound effect on the sensitivity of microscopy. The percentage of positive results increased from 25% with less than or equal to 10(3) CFU/ml to 60% in the range of greater than 10(3) to 10(5) CFU/ml and to 97% at concentrations of greater than 10(5) CFU/ml. Furthermore, a significant correlation (P less than 0.01) was noted between the concentration of bacteria in the CSF and the number of polymorphonuclear leukocytes observed on microscopy.