Miracle-dz/UniFAR-FTUs huggingface dataset:
Síntese de superfícies seletivas de frequência para micro-ondas utilizando otimização multiobjetivo bioinspirada

A evolucao da computacao tem possibilitado avancos substanciais em pesquisas relacionadas a engenharia e em projetos industriais. Nestas areas, o emprego de ferramentas computacionais tem se intensificado para simulacao e obtencao de determinados parâmetros do projeto. No entanto, a crescente demanda por precisao e o aumento gradativo da complexidade das estruturas e sistemas, resulta num processo de simulacao cada vez mais demorado, pois a avaliacao de um unico criterio pode consumir varias horas, bem como varios dias ou ate mesmo semanas. Logo, um metodo que minimize o tempo de simulacao e otimizacao, pode, assim, economizar tempo e dinheiro. Nesse contexto, a computacao bioinspirada (bioinspired computing - BIC), se apresenta precisa e eficiente, onde muitos metodos computacionais tradicionais falham e, consiste em novo mecanismo para suprir tais dificuldades. Assim, neste trabalho, e realizado um estudo acerca de alguns dos algoritmos BIC mais utilizados na atualidade para projeto e otimizacao de problemas gerais na engenharia e na industria. Doravante, se vislumbra desenvolver um codigo de otimizacao meta-heuristico multiobjectivo que apresente menor custo computacional e, consequentemente, menor tempo para processamento dos dados. Inicialmente, e realizada uma investigacao eletromagnetica das superficies seletivas de frequencia triangulares estudadas, atraves de simulacoes computacionais. A analise numerica de onda completa e feita pela tecnica das integrais finitas com o auxilio de um software comercial muito utilizado para simulacoes em eletromagnetismo. O processo de sintese consiste em sintonizar a frequencia de ressonância das estruturas e a largura de banda de acordo com os objetivos inseridos na funcao custo dos algoritmos de otimizacao. A modelagem das estruturas e realizada por uma rede neural artificial e o processo de otimizacao e realizado por algoritmos meta-heuristicos. Os resultados obtidos por esses codigos sao comparados aos simulados pelo software comercial e aos medidos. Observou-se boa concordância entre os resultados simulados e medidos, bem como uma substancial reducao no menor tempo de processamento das estruturas. Por fim, sao apresentadas as conclusoes e as propostas para trabalhos futuros.
Metagenomic‐based impact study of transgenic grapevine rootstock on its associated virome and soil bacteriome

Summary For some crops, the only possible approach to gain a specific trait requires genome modification. The development of virus‐resistant transgenic plants based on the pathogen‐derived resistance strategy has been a success story for over three decades. However, potential risks associated with the technology, such as horizontal gene transfer (HGT) of any part of the transgene to an existing gene pool, have been raised. Here, we report no evidence of any undesirable impacts of genetically modified (GM) grapevine rootstock on its biotic environment. Using state of the art metagenomics, we analysed two compartments in depth, the targeted Grapevine fanleaf virus (GFLV) populations and nontargeted root‐associated microbiota. Our results reveal no statistically significant differences in the genetic diversity of bacteria that can be linked to the GM trait. In addition, no novel virus or bacteria recombinants of biosafety concern can be associated with transgenic grapevine rootstocks cultivated in commercial vineyard soil under greenhouse conditions for over 6 years.
Analysis of one step delay in direct torque control of permanent magnet synchronous motor and its remedies

One-step delay in digital implementation of direct torque controlled (DTC) AC motor drives leads to large torque ripple and low switching frequency. Two remedies are proposed in this paper to eliminate the one-step delay. One is based on model-based prediction, which is complex and relies much on the model; the other is based on the multiple sampling of stator current. Different from the model-based method, the stator current prediction in the second method is achieved by using linear extrapolation, which does not require the motor model. By using the one-step compensation, the torque and flux ripples are reduced effectively and the switching frequency is increased, making better use of the power converters. The two remedies are firstly simulated in Simulink, and then experimentally verified in a permanent magnet synchronous motor (PMSM) DTC drive, validating the effectiveness of the proposed methods.
G.T wobble base‐pairing in Z‐DNA at 1.0 A atomic resolution: the crystal structure of d(CGCGTG).

The DNA oligomer d(CGCGTG) crystallizes as a Z‐DNA double helix containing two guanine‐thymine base pair mismatches of the wobble type. The crystal diffracts to 1 A resolution and the structure has been solved and refined. At this resolution, a large amount of information is revealed about the organization of the water molecules in the lattice generally and more specifically around the wobble base pairs. By comparing this structure with the analogous high resolution structure of d(CGCGCG) we can visualize the structural changes as well as the reorganization of the solvent molecules associated with wobble base pairing. There is only a small distortion of the Z‐DNA backbone resulting from introduction of the GT mismatched base pairs. The water molecules cluster around the wobble base pair taking up all of the hydrogen bonding capabilities of the bases due to wobble pairing. These bridging water molecules serve to stabilize the base‐base interaction and, thus, may be generally important for base mispairing either in DNA or in RNA molecules.
Lowest order hadronic contribution to the muon g-2 value with systematic error correlations.

We have performed a new evaluation of the hadronic contribution to {ital a}{sub {mu}}=({ital g}{minus}2)/2 of the muon with explicit correlations of systematic errors among the experimental data on {sigma}({ital e}{sup +}{ital e}{sup {minus}}{r_arrow}hadrons). Our result for the lowest order hadronic vacuum polarization contribution is {ital a}{sub {mu}}{sup had}=702.6(7.8)(14.0){times}10{sup {minus}10} where the first error is statistical and the second is systematic. The total systematic error contributions from below and above {radical}{ital s}=1.4 GeV are (13.1){times}10{sup {minus}10} and (5.1){times}10{sup {minus}10}, respectively, and are hence dominated by the low energy region. Therefore, new measurements on {sigma}({ital e}{sup +}{ital e}{sup {minus}}{r_arrow}hadrons) below 1.4 GeV can significantly reduce the total error on {ital a}{sub {mu}}{sup had}. In particular, the effect on the total errors of new hypothetical data with 3{percent} statistical and 0.5{endash}1.0{percent} systematic errors is presented. {copyright} {ital 1996 The American Physical Society. }
Quantifying the Contribution of Organisms to the Provision of Ecosystem Services

Research on ecosystem services has grown rapidly over the last decade. Two conceptual frameworks have been published to guide ecological assessments of organisms that deliver services—the concepts of service-providing units (SPUs) and ecosystem service providers (ESPs). Here, we unite these frameworks and present an SPU-ESP continuum that offers a coherent conceptual approach for synthesizing the latest developments in ecosystem service research, and can direct future studies at all levels of organization. In particular, we show how the service-provider concept can be applied at the population, functional group, and community levels. We strongly emphasize the need to identify and quantify the organisms and their characteristics (e.g., functional traits) that provide services, and to assess service provision relative to the demands of human beneficiaries. We use key examples from the literature to illustrate the new approach and to highlight gaps in knowledge, particularly in relation to the impact of species interactions and ecosystem dynamics on service provision.
Manufacturing process modeling of Boeing 747 moving line concepts

There are thousands of jobs performed on the Queen of the Sky, the Boeing 747, final assembly line for each airplane. When the decision was made to implement a moving line for the final assembly of the 747 it was absolutely necessary to evaluate many aspects of these jobs. Discrete event simulation models were constructed to analyze numerous 747 final assembly moving line scenarios throughout several phases. These models not only presented a visual understanding of different concepts, but also provided quantitative analysis of suggested scenarios to the moving line team. The results presented highly optimized production flows and processes, reducing cost and flow time from the traditionally 24 days to the targeted possible 18 days. This work outlined some of the moving line concepts, modeling objectives, and simulation analysis. Utilizations of different assembly positions were yielded as the result of discrete simulation modeling of many bundled jobs and stands of the 747 final assembly operation.
Thrombolysis in the 3- to 4.5-hour window: what do ECASSkeptics want?

Our patient has no contraindications for intravenous thrombolysis and meets the eligibility criteria specified in European Cooperative Acute Stroke Study (ECASS) III. Therefore, at first glance it seems that there is no basis for disagreement or controversy. He should be treated immediately with intravenous recombinant tissue-type plasminogen activator (rtPA) in line with the results of ECASS-III, a blinded, randomized, placebo-controlled trial, and professional guidelines including the American Heart Association/American Stroke Association (class I; Level of Evidence B recommendation). This position is strongly articulated by Drs Schellinger and Kohrmann. Is it really true that the 4.5-hour window for intravenous rtPA is so firmly established? Dr Wechsler expresses some doubts, and he is not alone. The United States Food and Drug Administration, the largest agency regulating medical products on planet earth, denied an application to extend the time window for intravenous rtPA treatment to 4.5 hours. The details of the application and the reasons behind the Food and Drug Administration’s denial have not been released to the scientific community, leading to speculations that the evidence from ECASS-III and supporting data were not sufficient in the Food and Drug Administration’s opinion. ECASS-III is a landmark study in …
Autoinhibition of the Kit Receptor Tyrosine Kinase by the Cytosolic Juxtamembrane Region

ABSTRACT Genetic studies have implicated the cytosolic juxtamembrane region of the Kit receptor tyrosine kinase as an autoinhibitory regulatory domain. Mutations in the juxtamembrane domain are associated with cancers, such as gastrointestinal stromal tumors and mastocytosis, and result in constitutive activation of Kit. Here we elucidate the biochemical mechanism of this regulation. A synthetic peptide encompassing the juxtamembrane region demonstrates cooperative thermal denaturation, suggesting that it folds as an autonomous domain. The juxtamembrane peptide directly interacted with the N-terminal ATP-binding lobe of the kinase domain. A mutation in the juxtamembrane region corresponding to an oncogenic form of Kit or a tyrosine-phosphorylated form of the juxtamembrane peptide disrupted the stability of this domain and its interaction with the N-terminal kinase lobe. Kinetic analysis of the Kit kinase harboring oncogenic mutations in the juxtamembrane region displayed faster activation times than the wild-type kinase. Addition of exogenous wild-type juxtamembrane peptide to active forms of Kit inhibited its kinase activity in trans, whereas the mutant peptide and a phosphorylated form of the wild-type peptide were less effective inhibitors. Lastly, expression of the Kit juxtamembrane peptide in cells which harbor an oncogenic form of Kit inhibited cell growth in a Kit-specific manner. Together, these results show the Kit kinase is autoinhibited through an intramolecular interaction with the juxtamembrane domain, and tyrosine phosphorylation and oncogenic mutations relieved the regulatory function of the juxtamembrane domain.
COPROCESSOR DESIGN FOR MATRIX MULTIPLICATION

High performance applications have become extremely popular in modern computer systems, with the rapid development and wide application of computer technology. This requires enhanced computation capabilities at low cost and power consumption. Also, in signal processing and communication applications, a high throughput rate and numerical accuracy is often demanded. One of the important requirements in such applications is to perform a large number of mathematical calculations in a very less time. That is, faster computational methods are vastly claimed for advancement in technology. In order to meet out the above requirements a layout of matrix multiplication is suggested. In this paper RTL and technology schematics, synthesis results, design statistic, macro statistic, timing report summary and general details about matrix addition and multiplication is described. In the present work matrix of order two is taken. Since in matrix multiplication there are two processes: multiplication and addition. So first floating point matrix addition is described and then matrix multiplication is discussed. Keywords— Processor, Multiplication, Floating Point, Vedic
Apidaecin multipeptide precursor structure: a putative mechanism for amplification of the insect antibacterial response.

Apidaecins are the most prominent components of the honeybee humoral defense against microbial invasion. Our analysis of cDNA clones indicated that up to 12 of these short peptides (2 kDa) can be generated by processing of single precursor proteins; different isoforms are hereby linked in one promolecule. Assembly of the multipeptide precursors and the putative three‐step maturation are strongly reminiscent of yeast alpha‐mating factor. Bioactive apidaecins are flanked by the two ‘processing’ sequences, EAEPEAEP (or variants) and RR; joined together, they form a single unit that is repeated numerous times. The number of such repeats is variable and was reflected in the observed diversity of transcript lengths. Each such transcript is likely to be encoded by a different gene, forming a tight gene cluster. While transcriptional activation upon bacterial challenge is not exceptionally fast, the multigene and multipeptide precursor nature of the apidaecin genetic information allows for amplification of the response, resulting in a real overproduction of peptide antibiotic. Enhanced efficiency of the ‘immune’ response to bacterial infection through such a mechanism is, to our knowledge, unique among insects.
Multiple regulators and their interactions in vivo and in vitro with the cbb regulons of Rhodobacter capsulatus.

The cbb(I) and cbb(II) operons encode structural genes which are important for carbon dioxide fixation via the Calvin-Benson-Bassham reductive pentose phosphate pathway in Rhodobacter capsulatus. Each operon is regulated by cognate LysR-type transcriptional activators, CbbR(I) and CbbR(II), with the product of the cbbR(I) gene, CbbR(I), able to control its own transcription under some growth conditions. Furthermore, CbbR(I) may at least partially regulate the cbb(II) operon, with significant, yet regulated transcription of the cbb(II) operon occurring in the absence of any CbbR. These results suggested the importance of additional regulators. Thus, in addition to the rather specific control exerted by CbbR, a more globally significant regulatory system, the RegA-RegB (PrrA-PrrB) two-component system, was found to contribute to transcriptional regulation of each cbb operon. The regA and regB mutant strains were found to contain constitutive levels of form I and form II RubisCO, the major proteins encoded by the cbb(I) and cbb(II) operons, respectively. In addition, DNaseI footprint analyses indicated that RegA*, a constitutively active mutant form of RegA, binds specifically to cbb(I) and cbb(II) promoter-operator regions. CbbR(I), CbbR(II), and RegA binding loci were localized relative to transcription start sites, leading to a coherent picture of how each of these regulators interacts with specific promoter-operator sequences of the cbb operons.
Sir2 deletion prevents lifespan extension in 32 long‐lived mutants

Activation of Sir2 orthologs is proposed to increase lifespan downstream of dietary restriction. Here, we describe an examination of the effect of 32 different lifespan‐extending mutations and four methods of DR on replicative lifespan (RLS) in the short‐lived sir2Δ yeast strain. In every case, deletion of SIR2 prevented RLS extension; however, RLS extension was restored when both SIR2 and FOB1 were deleted in several cases, demonstrating that SIR2 is not directly required for RLS extension. These findings indicate that suppression of the sir2Δ lifespan defect is a rare phenotype among longevity interventions and suggest that sir2Δ cells senesce rapidly by a mechanism distinct from that of wild‐type cells. They also demonstrate that failure to observe lifespan extension in a short‐lived background, such as cells or animals lacking sirtuins, should be interpreted with caution.
A semantically-based approach to the annotation of narrative style

This work describes the annotation of the novel "The Solid Mandala" (Patrick White, 1966), carried out combining sentiment and opinion mining on character level with the Appraisal Theory framework, here used to identify evaluative statements and their contribution to the social dimension of the text. Our approach was inspired by research on the correlation between White’s style and the personality of his main characters. The annotation was manually executed by second author using an XML standard markup system and double-checked by first author. In this paper we comment on the selected features, focusing on the ones acquiring specialized meaning in the context of the novel, and provide results in terms of quantitative data. Comparing them, we are able to extract story units in which special or significant events take place, and to predict the presence or similar units in the narrative by detecting concentrations of features. Eventually collecting all annotations has made available a lexicon where all ambiguities are clearly identifiable and verifiable. The lexicon will be used in the future for the automatic annotation of other novels.
CHANGES IN ACTIVITY AND EXCITABILITY OF CORTICAL AUDITORY RECEPTIVE UNITS OF THE CAT AS A FUNCTION OF DIFFERENT BEHAVIORAL STATES *

The ability of the cortex to process complex information is thought to depend on patterns of interconnection within the cortical neural network and on the efficacy of transmission within plastic neural elements. The former was recognized explicitly by Pavlov in 1927,13 the latter by Hebb in 1949.6 Accordingly, analysis of cortical unit function related to behavior should require some assessment of the state or level of unit excitability, as well as characterization of unit activity with respect to the units’ sensory receptive properties and motor projection. Such studies have been conducted on auditory receptive units in cats in collaboration with J. Engel, Jr., P. Black-Cleworth, T. Crow, and J. KnispeL3, 25. 26 The results indicate that both the excitability and activity of cortical units change as a function of behavioral state. The changes may be either persistent or transient in duration and are mediated by at least two different cellular mechanisms. Auditory receptive units are defined on the basis of their short latency response to acoustic stimuli, such as 60-70 db click or hiss. Units with 8-40 msec latency responses to click and hiss are not confined to “primary” cortical auditory receptive areas (FIGURE 1 A ) , This is not surprising, since previous gross potential studies showed responses to click over widespread cortical
Susceptibility to Heavy Metals and Characterization of Heterotrophic Bacteria Isolated from Two Hydrothermal Vent Polychaete Annelids, Alvinella pompejana and Alvinella caudata

Specimens of alvinellid polychaetes and their tubes were collected in the Parigo hydrothermal vent field on the East Pacific Rise (13°N) in October and November 1987. Heterotrophic bacterial strains were isolated on metal-amended media from the tube and dorsal integument of one specimen of Alvinella pompejana, from the dorsal integument of another from the whole integument of a specimen of Alvinella caudata, and from undetermined alvinellid tubes. The strains were characterized and tested for susceptibility to five heavy metals by using a microdilution method for MIC determinations. All strains were gram-negative rods. Most of them were characterized by the ability to degrade Tween 80 and gelatin and to produce hydrogen sulfide from cysteine. Numerous strains, from all sample origins, displayed resistance to cadmium, zinc, arsenate, and silver and tolerated high amounts of copper. Metal resistance was exhibited by 92.3% of the total isolates. The occurrence of multiply resistant bacteria may demonstrate an adaptation of alvinellid-associated microflora to the general enrichment of metals in the hydrothermal vent environment.
Comparison of different auto-solid angle approximations in BEM for EEG dipole source localization

The solution of the forward problem in electroencephalography requires the computation of the potential distribution on the surface of an isolated conductor, generated by a known source. In order to solve the problem in realistic head-shaped conductors, numerical methods must be used, such as boundary element method (BEM). In the BEM the surface of the volume conductor is subdivided in triangles and the potential is calculated at the centres of gravity, or collocation points, of these triangles. Key to the BEM is the estimation of the solid angle subtended by a triangle at a given collocation point. Particular care must be taken when considering the auto-solid angle, i.e. the solid angle subtended by a triangle at a point which belongs to that triangle. In this work we investigate the effect of the number of collocation points and we compare different approximations of the auto-solid angle commonly used in literature by means of the relative difference measure (RDM). We found that the finer the tessellation the smaller the median RDM and the narrower the distribution of RDM values. Moreover, we found that the use of the "one solid angle" approximation clearly outperforms the other approximations in terms of RDM.