Miracle-dz/UniFAR-FTUs huggingface dataset:
Antispasmodic effect of hydroalcoholic and flavonoids extracts of Dracocephalum kotschyi on rabbit bladder

Introduction: Dracocephalum kotschyi extract has antispasmodic activities on smooth muscle including ileum, uterus and trachea. The objective of this research was to investigate antispasmodic activity of hydroalcoholic and flavonoids extracts of D. kotschyi on rabbit bladder contractions. Methods: Rabbits were euthanized by carbon dioxide asphyxiation and the whole bladder was dissected out and immersed in the Tyrode’s solution. Longitudinal bladder strips were mounted vertically in an organ bath at 37°C and gassed continuously with O2 . Bladder strips were contracted with acetylcholine (ACh), KCl, or electrical field stimulation (EFS). Isotonic tension of the tissue was recorded before and after addition of hydroalcoholic or flavonoids rich extracts of D. kotschyi. Nifedipine and propantheline were used as standard drugs. Results: Standard drug propantheline, prevented bladder phasic contraction induced by ACh (1µM) without affecting KCl response. On the other hand, cumulative addition of nifedipine attenuated the tonic contractions induced by KCl (20mM) on bladder smooth muscle. Hydroalcoholic and flavonoids extracts of D. kotschyi at concentration ranges of 10-320 µg/ mL in a concentration dependent way inhibited bladder tonic contraction induced by KCl (n=6). Both extracts also in a concentration-dependent manner relaxed EFS and ACh-induced contractions (range, 20–1280 µg/mL) of bladder smooth muscle in vitro. Complete inhibition was achieved with the highest used concentrations of the extracts. The inhibitory effect of the extract was reversible following washing the tissues with fresh Tyrode’s solution. Conclusion: This study clearly demonstrated that D. kotschyi extracts were able to prevent contractions induced by ACh, KCl or EFS in isolated rabbit bladder. This means that people consuming this medicinal plant may face urinary retention which could be a problem for patients with prostate hypertrophy. On the other hand, this plant might be useful in patients with urinary incontinence. However, its usefulness must be assessed in the controlled clinical trials.
Evaluation of sulfur and foliar application of Zn and Fe on yield and biochemical factors of cumin (Cuminum cyminum L.) under irrigation regimes

Introduction: Cumin, due to its food and medicinal properties, is one of the important plant species in the world. Moreover, water and nutrition deficiencies are serious abiotic stress factors. So, this experiment was conducted with the aim of investigating the effects of sulfur and foliar application of Fe and Zn on yield and biochemical characteristics of cumin under irrigation regimes. Methods: The experiment was conducted as a split plot on the basis of a completely randomized block design during the 2016-2017 growing seasons with three replications. Experimental factors were arranged in irrigation regimes as main plots at three levels (I1: No stress (control), I2: irrigation based on 40% available water discharge, I3: 80% available water discharge) and foliar application of Zinc (Zn) and Iron (Fe) as subplots [F1: control (water-soluble), F2: Iron, F3: Zinc, F4: Zinc and Iron chelate] and sub-sub plots including sulfur fertilizer [S1: control (no use of sulfur), S2: sulfur fertilizer with Thiobacillus]. Results: Analyzed data showed that total phenol content and flavonoids were enhanced with the increase of drought intensity and the maximum amount was recorded under I3, while I3 caused a substantial reduction in grain yield. Flavonoid and grain yield significantly increased in F4. Total phenol content was the highest in F2 and F3 treatments. Application of sulfur fertilizer resulted in a significant increase in peroxidase, phenol and flavonoids. The highest amount of peroxidase was obtained in I3F4 and I3F3. The largest total soluble sugar (TSS) was resulted by I3S2 and the least by I1S1. Foliar application of Zn and Fe with sulfur fertilizer increased TSS. Conclusion: The present study suggests that foliar application of Fe and Zn and sulfur fertilizer can improve the injurious effects of water deficiency on cumin plant through alteration in yield and biochemical characteristics.
ANG OTENS N-CONVERT NG ENZYME POLYMORPH SM N EL TE TAEKWONDO ATHLETES OF TURK SH AND AZERBA JAN TAEKWONDO TEAMS

A few attempts have been made to shed light upon the influence of genes in making an Olympic champion. The aim of our study is to elucidate the genetic differences among 18 athletes from National Turkish and Azerbaijan taekwondo teams. Athletes were defined as elite. Angiotensin converting enzyme (ACE) genotypes of athletes were analyzed by polymerase chain reaction technique (PCR) in this study. The ACE gene is located on human chromosome 17 expressing three genotypes within the intron 16 of the related gene structure. These genotypes are classified as I and D alleles which are termed as insertion and deletion, respectively. Genomic DNA was isolated from peripheral blood and blood stain samples of control and sportsmen. First of all, the genotyping of ACE gene was performed by site specific ACE primers using PCR. To avoid mistyping, each sample found to have the DD genotype was amplified by inserting specific primers. As a result,18 samples including 2 II genotype, 11 ID genotype and 5 DD genotype were determined by conventional PCR. Allele frequencies were determined by gene counting. Genotype and allele frequencies between groups were compared by Chi-square test. P values of >0.05 were not considered statistically significant. There was no difference in ACE genotype frequencies between sedentary group and elit athletes.
Toxicity of some insecticides against Agrotis spp. infesting cabbage

Toxicity of seven insecticides viz., bifenthrin, chlorantraniliprole, cypermethrin, emamectin benzoate, flubendiamide, novaluron and spinosad was evaluated through leaf dip and topical methods of bioassay against third instar larvae of Agrotisipsilon(Hufnagel) and A. segetum (Denis andSchiffermuller). Based on LC50 values, chlorantraniliprole was found the most effective against third instar larvae of A. ipsilon (0.0298 ppm) as well as A. segetum (0.0321 ppm) while cypermethrin was the least effective, with LC50 values of 31.0706 and 33.4636 ppm, respectively. On the basis of LD50, chlorantraniliprole was observed to be the most effective against third instar larvae of A. ipsilon (0.00086 μga.i./ larva) as well as A. segetum (0.00085 μga.i./ larva) while novaluron being the least effective with LD50 values 0.8382 and 0.7441 μga. i. / larva, respectively.
HUBUNGAN ANEMIA DENGAN KUALITAS HIDUP PASIEN GAGAL JANTUNG KRONIK

Latar Belakang Gagal jantung kronik merupakan sindroma klinik yang kerap dijumpai pada orang dewasa dengan prevalensi 0,13% di Indonesia. Anemia merupakan prediktor independen terhadap mortalitas dan morbiditas pasien gagal jantung kronik. Kualitas hidup merupakan indikator yang penting untuk melihat keberhasilan terapi dari segi perspektif pasien. Tujuan: mengetahui hubungan antara kadar hemoglobin dengan kualitas hidup pasien gagal jantung kronik. Metode Penelitian ini dilakukan dengan desain cross sectional pada pasien gagal jantung kronik yang dirawat di RSUP Dr. Kariadi dengan metode consecutive sampling (n=32). Data yang digunakan adalah data primer berupa kuisioner kualitas hidup MLHFQ dan data sekunder berupa kadar hemoglobin pasien saat awal masuk rawat inap melalui data rekam medis. Hasil Data kadar hemoglobin yang telah diklasifikasikan derajatnya sesuai kriteria WHO dianalisis dengan uji korelasi Spearman dengan skor kualitas hidup MLHFQ yang terbagi menjadi dimensi fisik, emosi, umum, dan keseluruhan dan tidak didapatkan hubungan yang bermakna (p>0,05) dengan kekuatan korelasi lemah untuk dimensi fisik (r : -0,212), dan sangat lemah untuk dimensi lain (r<0,2). Terdapat hubungan yang bermakna (p<0,05), dengan korelasi sedang, antara kelas fungsional dengan kualitas hidup dimensi fisik, umum, (r:0,401) dan keseluruhan (r:0,496). Kesimpulan Kadar hemoglobin tidak memiliki hubungan yang signifikan dengan kualitas hidup pasien gagal jantung kronik.
Efeito de antibiótico vetorizado com nanopartículas magnéticas para tratamento da infecção por Staphylococcus aureus multirresistente

xii LISTA DE FIGURAS E GRÁFICOS . xiii LISTA DE TABELAS . xiv LISTA DE ABREVIATURAS E SIGLAS . xv 1. INTRODUÇÃO . 19 2. JUSTIFICATIVA . 24 3. OBJETIVOS . 25 3.1 Objetivo geral . 25 3.2 – Objetivos específicos . 25 4. MÉTODOS . 26 4.1 Síntese de Magnetita padrão . 26 4.2 Complexação magnetita@Oxacilina . 26 4.3 – Ensaios in vitro . 26 4.3.1 – Ensaios com bactérias . 26 4.3.2 – Ensaios com células eucarióticas . 29 4.4 – Ensaios in vivo . 30 4.4.1 – Estudo de Biodistribuição . 31 4.4.2 – Estudo da atividade antimicrobiana . 32 4.4.3 – Dosagens bioquímicas . 33 4.4.3 – Estudo histopatológico . 34 4.5 – Análise estatística . 34 5 ARTIGOS PRODUZIDOS . 36 6 COMENTÁRIOS, CRÍTICAS E SUGESTÕES . 77 6.1 – Projeto original . 77 6.2 Multidisciplinaridade . 82 6.3 Evolução intelectual . 82 6.4 Metas atingidas e perspectivas . 83 6.5 – Produção Intelectual . 84 6.6 – Considerações finais . 88 7 REFERÊNCIAS . 89 8 – ANEXO . 96 8.1 Parecer da Comissão de Ética no Uso de Animais . 96
TOOL LIFE AND SURFACE ROUGHNESS IN DRY HIGH SPEED MILLING OF ALUMINUM ALLOY 7075-T6 USING BULL NOSE CARBIDE INSERT

The paper reports the findings of the experimental work to study the impact of machining parameters, particularly cutting speed, feed rate, and axial depth of cut towards cutting tool life and machined surface roughness in high-speed milling aluminium alloy 7075-T6 with bullnose cutter under dry environment. Previous studies found that tool life and surface roughness in machining aluminium alloy 7075-T6 using cemented carbide are unfavourable compared to other materials. However, this observation needs further study. Thus, a raw block of aluminium alloy 7075-T6 was proposed in this experiment. An eight-run experiment was designed according to full factorial design based on two levels of cutting speed (500 m/min, 600 m/min), feed rate (0.12 mm/tooth, 0.15 mm/tooth), and axial depth of cut (1.40 mm, 1.70 mm) and then analysed employed ANOVA. Cutting tool life was restricted by tool wear in the milling process. The microscope and portable surface roughness tester were employed to analyse tool wear and average surface roughness value. Cutting speed and feed rate were found to be a significant factor to the tool life and surface roughness. The longest tool lifespan of 16.79 minutes and lowest surface roughness value of 0.595 μm were determined at a speed of 500 and 600 m/min, respectively, with a low combination of the rest of parameter, which are 0.12 mm/tooth and 1.40 mm.
Efficacy of radial artery superficial palmar branch perforator flap in repairing soft tissue defects in the finger

Objective: To observe the efficacy of radial artery superficial palmar branch perforator flap in treating soft tissue defects of the finger. Methods: A total of 74 patients with hand flexor tendon injury admitted to the department of hand surgery were randomly divided into two groups, among which 39 patients treated with flap repair based on the vascular chain of lateral finger cutaneous branches, were assigned to a control group, and the other 35 patients treated with radial artery superficial palmar branch perforator flap were assigned to an observation group. The following aspects of all the patients were assessed and compared: Flap survival rate, total active movement (TAM), pressure pain threshold (PPT), Moorfields motion displacement test (MMDT) results, and complications after surgery. Results: The observation group showed a higher flap survival rate than the control group (P<0.05), and also performed better than the control group in terms of TAM, PPT, and MMDT (all P<0.05). In addition, the observation group showed a significantly lower complication rate than the control group after surgery (P<0.05). Conclusion: Radial artery superficial palmar branch perforator flap is more effective than cutaneous branches-chain flap in treating soft tissue defects of the finger, and contributes to a higher flap survival rate, faster recovery of hand function, and lower complication rate for patients, so it is worthy of popularization and application in clinical practice.
Investigation the Relationship between Spermatogenesis and the Levels of Some Hormones in a Sample of Infertile Iraqi Males with Azoospermia and Oligospermia

The objective of this study was to assess the levels of antiMullerian hormone (AMH), Follicle stimulating hormone (FSH), testosteron, luteinizing hormone (LH), and estradiol (E2) as markers of spermatogenesis between fertile and infertile males. This study was conducted at (AlRamadi Teaching Hospital for maternity and children) and included 136 males partners of infertile couples. Samples were classified according to the WHO criteria of semen analysis into three groups; Azoospermia, Oligospermia, and normal(control). Assay levels of these hormones were made in the serum and the semen of each sample. The results showed that the level of AMH in serum samples was non-significantly decreased ( P >0.05) in both Azoospermia and Oligospermia groups compared to control (6.74±3.21 ng/ml and 6.01±0.25 ng/ml vs. 12.81±7.69 ng/ml). While FSH and LH levels, there were non-significantly(P > 0.05) increased in both azoospermia and Oligospermia compared to control (FSH: 12.11±8.14 mIU/ml and 7.22±6.06 mIU/ml vs. 3.14±1.27 mIU/ml; LH: 10.04±7.23 mIU/ml and 7.62±3.30 mIU/ml vs. 5.57±2.03mIU/ml). In addition, there were non- significant differences ( P > 0.05) of testosterone hormone level among the studied groups. Such, there was a non-significant decreased level of E2 ( P > 0.05) in both Azoospermia and Oligospermiagroups compared to control (170.49±37.57 ng/ml and 137.20±53.92 ng/ml vs. 194.91±41.66 ng/ml). In contrast to semen samples, the results of AMH showed a significant ( P 0.05) increased in Azoospermia and Oligospermia compared to control (3.97±1.91 mIU/ml and 4.09±2.50 mIU/ml vs. 2.47±1.29 mIU/ml). Such, there were non-significant ( P > 0.05) increased levels of LH and testosterone hormones in both Azoospermia and control compared to Oligospermia (9.35±6.02 mIU/ml and 5.99±4.43 mIU/ml vs. 4.06±2.82 mIU/ml), and significant ( P < 0.05) increased level of E2 in both Azoospermia and Oligospermia compared to control (241.36±35.32 ng/ml and 220.86±48.96 ng/ml vs. 170.71±73.52 ng/ml). The study concluded that the AMH, FSH and E2 hormones levels in serum and semen samples may have been associated with the sperm production and may be a good marker for spermatogenesis, as well as Sertoli cell development. In addition, the age played a critical role in the level of the studied hormones.
Prevalence of Toxoplasma gondii and Associated Risk Factors among Pregnant Women Attending Hospital Centers in Penka-Michel, Cameroon

Aims: This study was carried out to investigate the epidemiology of toxoplasmosis and associated predisposing risk factors in a rural setting of Cameroon. Methodology: The survey took place from April to July 2014 at the District Medical Center of Balessing, the District Medical Center of Bansoa chefferie, the District Medical Center of Eglise Evangelique du Cameroun and the District Hopital of Penka-Michel, 4 reference hospitals in Penka-Michel, a sub-division in the west region of Cameroon.Serum samples were collected from 643 pregnant women attending the ante natal clinic after obtaining informed consent. Toxoplasma gondii-specific IgG antibodies were detected by indirect solid-phase enzyme immunoassay (EIA), immunoComb® Toxo lgG. A structured questionnaire was used to collect Original Research Article Kouitcheu et al.; JSRR, 21(2): 1-11, 2018; Article no.JSRR. 33061 2 information on sociodemographic parameters and predisposing risk factors for toxoplamosis from each patient. The data were analyzed using GraphPad prism version 5.03. Results: The age range of the women was 15-50 years with a mean of 27.1 ± 2.51 years. The mean gestational age was 6.22 ±1.93 months with, 9.8%, 39.5% and 50.7% of the women in the first, second and third trimester respectively. The overall IgG seroprevalence was 35.77% (230/643) of our sample population. There was a statistically significant association between Toxo IgG seropositivity status, educational level, professional status, had knowledge on toxoplamosis and frequency of raw meat consumption with a significantly higher risk of being seropositive amongst farmers and housewives (X 2 =13.28; P = .0100), among women with university level of education (X =11.77; P = .0082), among women with knowledge on toxoplamosis (P = .0001) and those who frequently consume raw meat (P = .0426). Conclusion: Our data found out a high risk of toxoplasmosis in pregnant women, and a general screening program for toxoplasmosis in pregnancy in Cameroon should be done.
A kinetic model for qualitative understanding and analysis of the effect of complete lockdown imposed by India for controlling the COVID-19 disease spread by the SARS-CoV-2 virus

The present ongoing global pandemic caused by SARS-CoV-2 virus is creating havoc across the world. The absence of any vaccine as well as any definitive drug to cure, has made the situation very grave. Therefore only few effective tools are available to contain the rapid pace of spread of this disease, named as COVID-19. On 24th March, 2020, the the Union Government of India made an announcement of unprecedented complete lockdown of the entire country effective from the next day. No exercise of similar scale and magnitude has been ever undertaken anywhere on the globe in the history of entire mankind. This study aims to scientifically analyze the implications of this decision using a kinetic model covering more than 96% of Indian territory. This model was further constrained by large sets of realistic parameters pertinent to India in order to capture the ground realities prevailing in India, such as: (i) true state wise population density distribution, (ii) accurate state wise infection distribution for the zeroth day of simulation (20th March, 2020), (iii) realistic movements of average clusters, (iv) rich diversity in movements patterns across different states, (v) migration patterns across different geographies, (vi) different migration patterns for pre- and post-COVID-19 outbreak, (vii) Indian demographic data based on the 2011 census, (viii) World Health Organization (WHO) report on demography wise infection rate and (ix) incubation period as per WHO report. This model does not attempt to make a long-term prediction about the disease spread on a standalone basis; but to compare between two different scenarios (complete lockdown vs. no lockdown). In the framework of model assumptions, our model conclusively shows significant success of the lockdown in containing the disease within a tiny fraction of the population and in the absence of it, it would have led to a very grave situation.
Cosmological dark matter amplification through dark torsion

A cosmological approach based on considering a cosmic background with non-zero torsion is shown in order to give an option of explaining a possible phantom evolution, not ruled out according to the current observational data. We revise some aspects of the formal schemes on torsion and, according them, we develop a formalism which can be an interesting alternative for exploring Cosmology.
Learning to Manipulate Individual Objects in an Image

We describe a method to train a generative model with latent factors that are (approximately) independent and localized. This means that perturbing the latent variables affects only local regions of the synthesized image, corresponding to objects. Unlike other unsupervised generative models, ours enables object-centric manipulation, without requiring object-level annotations, or any form of annotation for that matter. The key to our method is the combination of spatial disentanglement, enforced by a Contextual Information Separation loss, and perceptual cycle-consistency, enforced by a loss that penalizes changes in the image partition in response to perturbations of the latent factors. We test our method's ability to allow independent control of spatial and semantic factors of variability on existing datasets and also introduce two new ones that highlight the limitations of current methods.
High-Accuracy Malware Classiﬁcation with a Malware-Optimized Deep Learning Model

Malware threats are a serious problem for computer security, and the ability to detect and classify malware is critical for maintaining the security level of a computer. Recently, a number of researchers are investigating techniques for classifying malware families using malware visualization, which convert the binary structure of malware into grayscale images. Although there have been many reports that applied CNN to malware visualization image classiﬁcation, it has not been revealed how to pick out a model that ﬁts a given malware dataset and achieves higher classiﬁcation accuracy. We propose a strategy to select a Deep learning model that ﬁts the malware visualization images. Our strategy uses the ﬁne-tuning method for the pre-trained CNN model and a dataset that solves the imbalance problem. We chose the VGG19 model based on the proposed strategy to classify the Malimg dataset. Experimental results show that the classiﬁcation accuracy is 99.72 %, which is higher than other previously proposed malware classiﬁcation methods.
Bioactivity, Biocompatibility and Biomimetic Properties for Dental Materials: Clarifying the Confusion?

Often in the profession of dentistry, a new or novel instrument, material, technique, and/or â€œsystemâ€ is introduced which can incur a â€œstate-of-the-artâ€ status without necessarily being subjected to the rigors of clinical testing or longitudinal patient-based studies prior to receiving the stamp of approval or the moniker of â€œstandard of careâ€ . Recently, provocative terminology surrounding the field of dental materials has been publicized through the literature, promoting exciting claims and possible long-term advancements for patient care. In this â€œnew eraâ€ of evidence-based restorative dentistry, conservative interdiction, i.e. â€œinformedâ€ removal of diseased tissue with concurrent substitution considering form and function, esthetics, and the interaction of the physical and mechanical properties of the replacement materials with living, dynamic structures found in the human tooth, has been of paramount importance.
BLEU Might Be Guilty but References Are Not Innocent

The quality of automatic metrics for machine translation has been increasingly called into question, especially for high-quality systems. This paper demonstrates that, while choice of metric is important, the nature of the references is also critical. We study different methods to collect references and compare their value in automated evaluation by reporting correlation with human evaluation for a variety of systems and metrics. Motivated by the finding that typical references exhibit poor diversity, concentrating around translationese language, we develop a paraphrasing task for linguists to perform on existing reference translations, which counteracts this bias. Our method yields higher correlation with human judgment not only for the submissions of WMT 2019 English to German, but also for Back-translation and APE augmented MT output, which have been shown to have low correlation with automatic metrics using standard references. We demonstrate that our methodology improves correlation with all modern evaluation metrics we look at, including embedding-based methods. To complete this picture, we reveal that multi-reference BLEU does not improve the correlation for high quality output, and present an alternative multi-reference formulation that is more effective.