Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of [3H]mepyramine binding to the longitudinal muscle of guinea pig small intestine.

The antagonist-sensitive binding of [3H]mepyramine to a washed homogenate of the longitudinal muscle from guinea pig small intestine was largely that expected for binding to histamine H1-receptors. However, at pH 8.1 comparison of the extent of the inhibition of 10 nM [3H]mepyramine binding by mepyramine and promethazine revealed the presence of secondary nonreceptor binding sites. These sites were not apparent on making comparison at pH 7.5. Analysis of antagonist inhibition curves showed that for certain antagonists, most notably mepyramine, the Hill coefficient was significantly less than unity. However, the Hill coefficients for some antagonists approximated to unity, and there was in no case any significant difference between the level of antagonist-sensitive binding and that sensitive to inhibition by 2 µM promethazine. Histamine, 2-pyridylethylamine, and 2-thiazolylethylamine gave inhibition curves with Hill coefficients much less than unity. These agonists also inhibited [3H]mepyramine binding to a greater extent than did 2 µM promethazine. There were only small differences in the position of antagonist inhibition curves when measured in 50 mM phosphate buffer and in Krebs-phosphate solution. However, substitution of Krebs-phosphate for phosphate buffer produced an apparent increase in the affinity of the agonists. For histamine and 2-pyridylethylamine this increase in affinity occurred mostly in the high-affinity component of the curves. Omission of Ca2+ and Mg2+ from the Krebs-phosphate had no significant effect on the position of the inhibition curve for histamine.
Investigation of periodic modes in nonlinear systems with fractional order integrator

This paper investigates the effect of fractional order integrator on the nonlinear feedback systems. The effect of fractional order integrator, which is proposed to place in front of relay with dead zone on the second order system, is analysed comparatively using Describing Function method and simulation results. Since the proposed approach provides the opportunity for the selection of a wide phase range, it can be considered as an effective method to select relevant sampling frequency and to investigate limit cycles in modulators and demodulators that are used for signal conversion applications.
Comprehensive modeling, testing, and experimental validation of ultracapacitor open circuit voltage characteristics

Ultracapacitors (UCs) are the significant component of the energy storage systems (ESS) in the electric traction applications. In the field of electric transportation the UCs need to be modeled dynamically in order to capture real-time characteristics. The model should provide precise estimation of UC responses to various charge/discharge conditions and also predict the behavior of UCs under varied load conditions. In order to incorporate the model for testing purposes in various power electronics/drive simulation toolboxes, it is very important for the model to be accurate. This paper aims at the experimental validation of an accurate parameter identification procedure for an UC model using random charging/discharging current pulses of different magnitudes. The UC model can estimate the output voltage without the extraction of the model's branch parameters. The critical parameters have been estimated dynamically from characteristic equations. The estimation technique for an equivalent RC branch model is simulated and the output voltage response, controlled between Vmin (0V) and Vrated (2.7V) of a single UC cell, has been presented. Finally, the simulation results obtained from the identification technique are validated against the actual charging results obtained from applying charging pulses to a 1200F UC.
p38 Mitogen-Activated Protein Kinase: A Novel Modulator of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels and Neuronal Excitability

Hyperpolarization-activated cyclic nucleo-tide-gated (HCN) channels are permeable to Na+/K+ and underlie the inwardly rectifying current termed I h, I (f), or I q ([Santoro and Tibbs, 1999][1]). Regulated by voltage and the binding of ligands, there are four HCN isoforms that vary in their
Impact of Pharmacological Autonomic Blockade on Complex Fractionated Atrial Electrograms

Autonomic Blockade During Atrial Fibrillation. Introduction: The influence of the autonomic nervous system on the pathogenesis of complex fractionated atrial electrograms (CFAE) during atrial fibrillation (AF) is incompletely understood. This study evaluated the impact of pharmacological autonomic blockade on CFAE characteristics.
The wheat and the chaff: or four confusions regarding CHILDES

ABSTRACT Edwards (1992) presents a set of examples from the Child Language Data Exchange System (CHILDES) as prototypes of bad transcription practice. Her discussion is based upon four basic confusions. First, Edwards confuses old and discarded versions of CHAT with current CHAT. Second, she confuses the relation between CHAT standards with the implementation of these standards during the process of reformatting older corpora. Third, she confuses transcription for automatic analysis with transcription for documentation. Fourth, she confuses the CHAT guidelines with the larger CHILDES system. We argue that these confusions have misled Edwards into developing an overly rigid set of principles for data analysis which, if followed literally, could choke off progress in the analysis of spontaneous language samples.
Analysis of Upstream Region of Nicotianamine Synthase Gene from Arabidopsis thaliana: Presence of Putative ERE-like Sequence

Nicotianamine (NA) is present in all plants so far examined, and is thought to chelate transition metal ions. Previously, we isolated three nicotianamine synthase (NAS) genes of Arabidopsis thaliana (AtNAS1, 2, and 3) and showed that each NAS gene is differentially expressed. Deletion analysis of the 5' flanking region of AtNAS3 found a putative ethylene-responsive sequence, ATTTTCAAA.
Yellow Fever

Considering the great Importance of malaria in tropical practice, and the enormous accumulation of recent information on its various aspects, the sections on this disease are wholly Inadequate. The subject of treatment, of which a proper appreciation is at present rendered difficult to practitioners by the amount of published material appearing, is covered in about three pages. A similar deficiency exists In the section on control measures, where the use of pyrethrum and paris green receive the same space as that of DDT. Blackwater fever is dealt with in "a few clinical points" In little over a page. In a work of this size, It Is not enough to be told that blackwater fever Is "not too common", or that a "navy clinician who spent more than a decade in malarial areas saw only three cases in nine years . ". For It is when one of these rare cases suddenly appears that the practitioner, often far from consultative help, will turn to his reference book, and will reasonably expect some guidance In his procedure. Despite the above criticisms, the book contains many excellent sections, and presents much of great interest to tropical clinicians. For the reasons mentioned, however, it is not recommended to Australian students, or to practitioners in the Australian tropical territories.
Actinobacillus actinomycetem-comitans: Fermentative Capabilities of 140 Strains

Fermentative capabilities of 140 strains of Actinobacillus actinomycetem-comitans were studied. Findings correspond closely with those reported previously by Heinrich and Pulverer (12 strains), and by King and Tatum (33 strains). All strains ferment glucose, levulose, and maltose and reduce nitrate to nitrite. Reactions with glycogen and starch are exceedingly diverse. Eight different biotypes have been identified on the basis of their reactions with galactose, mannitol, and xylose.
A novel vascular endothelial growth factor, VEGF‐C, is a ligand for the Flt4 (VEGFR‐3) and KDR (VEGFR‐2) receptor tyrosine kinases.

Angiogenesis, the sprouting of new blood vessels from pre‐existing ones, and the permeability of blood vessels are regulated by vascular endothelial growth factor (VEGF) via its two known receptors Flt1 (VEGFR‐1) and KDR/Flk‐1 (VEGFR‐2). The Flt4 receptor tyrosine kinase is related to the VEGF receptors, but does not bind VEGF and its expression becomes restricted mainly to lymphatic endothelia during development. In this study, we have purified the Flt4 ligand, VEGF‐C, and cloned its cDNA from human prostatic carcinoma cells. While VEGF‐C is homologous to other members of the VEGF/platelet derived growth factor (PDGF) family, its C‐terminal half contains extra cysteine‐rich motifs characteristic of a protein component of silk produced by the larval salivary glands of the midge, Chironomus tentans. VEGF‐C is proteolytically processed, binds Flt4, which we rename as VEGFR‐3 and induces tyrosine autophosphorylation of VEGFR‐3 and VEGFR‐2. In addition, VEGF‐C stimulated the migration of bovine capillary endothelial cells in collagen gel. VEGF‐C is thus a novel regulator of endothelia, and its effects may extend beyond the lymphatic system, where Flt4 is expressed.
Implementation of gamification concept in the health complaint service system to improve the public health services system of Banyuwangi for supporting the health Indonesia program through a family approach

Gamification introduces game design elements into non game application by using competition, points, achievements, rules of play, status to encourage action through positive feedback such as motivating participation and loyalty. Now the Ministry of Health establishes an operational strategy through family approach to increase health services access in each unit. Banyuwangi support this program. The program' name is "pick up the ball, care for residents" for serving public health. This program requires the cooperation of citizens. Designing citizen interaction in providing information to health workers in improving the efficiency of work of officers visiting people can be built through a public health complaint service system. Designing business processes using gamification and adopting a family approach to the flow of the public health complaints service process. This reseach didn’t use statistical analysis but development design business process. The gamification concept implemented easily so increase interaction, participation, motivation and enthusiasm of users using the system so users actively provide respond because this concept is complemented by the challenge and reward through giving of point from collected activities by adopting a family approach can facilitate posyandu cadres in their duties because every family member helping posyandu cadres in controlling the health of family. Design of business process using a combination of gamification concepts and family approach can make it easier to draw up a Health Complaint Service System design so that it can support The Health Indonesia Program through a family Approach.
Predicting neuroleptic response from a combination of multilevel variables in acute schizophrenic patients

A predetermined set of 22 sociodemographic, psychosocial, clinical, neurocognitive and biochemical potential predictor variables was tested in 98 schizophrenic patients admitted for relapse. The patients were treated with neuroleptics, mostly with haloperidol, for 28 d. Ten of the 22 variables correlated significantly with the neuroleptic response. Using stepwise multiple regression analyses, an optimal combination of 5 predictors was found to be in hierarchical order: disturbances of premorbid adjustment, intensity of positive symptoms at admission, family history of schizophrenia, working ability during the year before admission and serum dopamine‐β‐hydroxylase. The 5 best predictors explained 29% of outcome variance, and all 22 variables together explained 35%. Such neurological characteristics as neurological soft signs, handedness, abnormal voluntary movements, spontaneous blink rate and cognitive impairment did not predict the treatment response. Several psychopathological, psychosocial and clinical predictors known from the literature could also be confirmed by cross‐validation.
PENGARUH PARTISIPASI ANGGOTA DAN KEWIRAUSAHAAN SERTA PERAN PEMERINTAH TERHADAP MOTIVASI KERJA DAN KINERJA KOPERASI SERBA USAHA DI PROVINSI KALIMANTAN TIMUR

Cooperative is an activity which is expected to be foundation of Indonesian economy as stated in the 1945 constitution. There were efforts to develop the work motivation in the multipurpose cooperative, which were held either by the government or practitioner. In this case, the government policy of presidential instruction. Furthermore, some expert and observed the cooperative with the aim give an input in order to increase and possess competitive effort with another business activity. However, up to present time, some ways to achieve it is not realized maximally. Based on the empirical observation study done at the multipurpose cooperativers in East Kalimantan Province, it could be conluded that: 1. Member Participation has positive significant influence on manager work; 2. Entrepreneurship character has positive significant influence on manager work motivation; 3. Government’s role has positive significant influence on manager work motivation; 4. Member Participation has positive significant influence on cooperative perpormance; 5. Entrepreneurship character has positive significant influence on cooperativce performance; 6. Government’s role has insingnificant influence on cooperative performance; 7. Work motivation has positive significant influence on cooperative performance. The result of this study can be conluded, that the governemtn’s role, especially to financial aim and loan facilities to multi purpose cooperative in east Kalimantan Province must be done by applying selective and strict requirement.
Multibank Holding Companies and Bank Stability

This paper studies the relationship between bank holding company affiliation and the individual and systemic risk of banks. Using the 2005 hurricane season in the US as an exogenous shock to bank balance sheets, we show that banks that are part of a holding parent company are more resilient than independent banks. Examining the impact of the liquidity of the holding on resiliency shows that banks are more fragile when the liquidity of the holding is lower, consistent with internal capital markets playing a role in stabilizing banks. We also show that banks whose holdings display low liquidity levels rebalance their portfolios towards riskier activities, such as non-traditional banking activities.
Haskell: The Craft of Functional Programming

From the Publisher: The second edition of Haskell: The Craft of Functional Programming is essential reading for beginners to functional programming and newcomers to the Haskell programming language. The emphasis is on the process of crafting programs and the text contains many examples and running case studies, as well as advice an program design, testing, problem solving and how to avoid common pitfalls. Building on the strengths of the first edition, the book includes many new and improved features: Complete coverage of Haskell 98, the standard version of Haskell which will be stable and supported by implementations for years to come. An emphasis on software engineering principles, encouraging a disciplined approach to building reusable libraries of software components. Detailed coverage of the Hugs interpreter with an appendix covering other implementations. A running case study of pictures emphasizes the built-in functions which appear in the standard prelude and libraries. It is also used to give an early preview of some of the more complex language features, such as high-order functions. List comprehensions and the standard functions over lists are covered before recursion. Early coverage of polymorphism supporting the "toolkit" approach and encouraging the resuse of built-in functions and types. Extensive reference material containing details of further reading in books, journals and on the World Wide Web. Accompanying Web Site supporting the book, containing all the program code, further teaching materials and other useful resources.
Consumer adoption of mobile banking in Jordan: Examining the role of usefulness, ease of use, perceived risk and self-efficacy

Purpose – The purpose of this paper is to propose and examine a conceptual model that best explains the key factors influencing Jordanian customers ' intention to adopt mobile banking (MB). Design/methodology/approach – The proposed conceptual model was based on the Technology Acceptance Model (TAM). This was extended by adding perceived risk and self-efficacy as an external factors. Structural equation modelling (SEM) was conducted to analyse the data collected from the field survey questionnaires administered to a convenience sample of Jordanian banking customers. Findings – The results showed that behavioural intention is significantly influenced by perceived usefulness, perceived ease of use, and perceived risk. Research limitations/implications – Practical and theoretical implications for both Jordanian banks and researchers in the MB context are also discussed in the concluding section. Originality/value – MB-related issues are yet to be examined empirically in the Jordanian context. This submission has attempted to fill this gap by empirically examining some of the important factors influencing the adoption of MB from the Jordanian customers’ perspective.
Evaluation of Argatroban as a Potential Anticoagulant for Clinical Laboratory Analysis: Precision, Stability and Interference Study.

BACKGROUND Argatroban is a small, synthetic molecule which is a direct thrombin inhibitor and has been confirmed to be a potent anticoagulant in clinical treatments. However, only a few applications related to laboratory medicine have been reported. The purpose of this study was to understand the performance and value of argatroban as an anticoagulant for clinical laboratory analysis in a single test tube. METHODS We examined 93 blood samples and evaluated the anticoagulation time, precision, stability, and interference of argatroban in routine laboratory tests. RESULTS The anticoagulation time was associated positively with the concentration of argatroban. Chemical and hematological results for argatroban-treated samples were similar to those obtained with serum or ethylenediaminetetraacetic acid treated specimens. Only the white blood cell count was decreased in the first 5 hours after blood collection and the difference was outside clinically acceptable limits; the mean corpuscular hemoglobin concentration was affected slightly by different concentrations of argatroban. CONCLUSIONS Argatroban is an attractive candidate for use as a laboratory anticoagulant that can be used for evaluation of chemical and hematological analytes in a single test tube in routine laboratory work.
Instradamento egoistico in reti multi-salto

Questa tesi discute il problema dell'instradamento egoistico nelle reti di comunicazione. Viene dapprima presentato lo stato dell'arte di tale problema illustrando cos'e stato studiato fino ad ora. Si introducono i concetti di base quali il costo totale, o sociale, gli equilibri di Nash e il prezzo dell'anarchia. Successivamente viene descritta una metodologia di valutazione del prezzo dell'anarchia tramite il software MATLAB. Sono riportati e spiegati passo passo gli algoritmi necessari al calcolo del flusso ottenuto tramite instradamento egoistico e del flusso ottimale. In seguito sono riportati i risultati di simulazioni svolte su diversi esempi significativi ricorrendo ad ampio uso di grafici che verranno discussi qualitativamente. Verra infine discusso il vantaggio o meno della presenza di controllo centralizzato nelle reti
Reduced Klotho is associated with the presence and severity of coronary artery disease

Objective Klotho is involved in vascular health. We aimed to analyse in a cross-sectional study the relationship between Klotho and human coronary artery disease (CAD). Methods The study included 371 subjects who underwent coronary angiography and 70 patients who underwent elective cardiac surgery recruited between May 2008 and June 2009. The presence and severity (stenosis index) of CAD, cardiovascular risk factors, Klotho gene expression in the thoracic aorta, and serum soluble Klotho concentrations were evaluated. Results The soluble Klotho concentration was lower (p<0.001) in patients with significant CAD (n=233). The maximal stenosis observed in every epicardial artery and the stenosis severity index was significantly lower in patients within the higher soluble Klotho concentrations (p<0.0001). Multiple regression analysis showed that serum Klotho concentrations were inverse and significantly associated with CAD (adjusted R2=0.67, p<0.001). Multivariate logistic regression analysis showed that risk factors for significant CAD included age, diabetes, smoking and inflammation, whereas high serum Klotho values were associated with a lower risk for CAD. Lower mRNA expression level of Klotho was observed in 46 patients with significant CAD, as compared with subjects without CAD (p=0.01). Logistic regression analysis showed that high Klotho gene expression was independently associated with lower risk for CAD. Conclusions Patients with significant CAD present lower soluble concentrations of Klotho, as well as reduced levels of Klotho gene expression in the vascular wall. Reduced serum Klotho concentrations and decreased vascular Klotho gene expression were associated with the presence and severity of CAD independently of established cardiovascular risk factors.
Effects of Internal Corporate Social Responsibility Practices On Employee Job Satisfaction: Evidence from Commercial Banks In Kenya

The importance of Internal corporate social responsibility (CSR) has become an important issue for banks to address, however, these issues have been neglected and do not appear to have the desired impact on all employees as expected by the management. Therefore this study intended to determine the effects of internal CSR practices on employee job satisfaction among the commercial Banks in Kenya. The study was to ascertain the effect of workplace health and safety conditions, work life balance, pay and benefits, and equality and diversity, on employee job satisfaction. The study was guided by Social exchange theory, the theory of planned behavior and Stakeholder theory. Explanatory research design was used. The study targeted 283 employees from 17 Commercial Banks in Uasin-Gishu (Kenya Commercial Bank data base, 2013). Stratified and random sampling technique was used to obtain sample size of 165 employees. The study used questionnaires as a tool for data collection. In order to test the reliability of the instrument, Crobanch alpha test was used. The study adopted both descriptive statistics and inferential statistics such as Pearson correlation and multiple regression analysis to estimate the causal relationships between internal CSR and employee job satisfaction, and other chosen variables. Study findings indicate that workplace health and safety, pay and benefit, equality and diversity, and work-life balance has a positive and significant effect on employee job satisfaction. Thus, the study concluded that pay and benefits are motivating factor to employees’ job satisfaction, fair treatment of workers in accordance with their individual needs and circumstances in the workplace contributes to employee job satisfaction. Therefore the study recommends that organizations should include the development of health management policies to implement health practices as a way of improving employee health. There should be diversity training programs with compulsory participation for all employees and offer equal opportunities for employees in terms of promotion and also education scholarships. There is also need for the organization to provide allowances for employees on participation of social responsibility.