Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors contributing to the helpfulness of online hotel reviews

Purpose This paper aims to examine the factors contributing to the helpfulness of online hotel reviews and to measure the impact of manager response on the helpfulness of online hotel reviews. Design/methodology/approach This investigation used a linear regression model that drew upon 56,284 consumer reviews and 10,797 manager responses from 1,405 hotels on TripAdvisor.com for analysis. Findings The helpfulness of online hotel reviews is negatively affected by rating and number of sentences in a review, but positively affected by manager response and reviewer experience in terms of reviewer status, years of membership, and number of cities visited. Manager response moderates the influence of reviewer experience on the helpfulness of online hotel reviews. Research limitations/implications Using the data from hotels in five major cities in Texas, the results may not be necessarily generalized to other markets, but the important role that manager response plays in online reviews is assessed with big data analysis. Practical implications The results suggest hospitality managers should strategically identify opinion leaders among reviewers and proactively influence the helpfulness of the reviews by providing manager response. Additionally, this study makes recommendations to webmasters of social media platforms in terms of advancing the algorithm of featuring the most helpful online reviews. Originality/value This study is at the frontier of research to explain how hotel managers can proactively identify opinion leaders among consumers and use manager response to influence the helpfulness of consumer reviews. Additionally, the results also provide new insights to the influence of reviewer demographic background on the helpfulness of online reviews. Finally, this study analyzed a large data set on a scale that was not available in traditional guest survey studies, responding to the call for big data applications in the hospitality industry.
Whole-genome Linkage Analysis and Sequence Analysis of Candidate Loci in Familial Breast Cancer.

BACKGROUND Known breast cancer-predisposing genes account for fewer than 25% of all familial breast cancer cases and further studies are required to find the remaining high- and moderate-risk genes. We set-out to couple linkage analysis using microsatellite marker data and sequence analysis of linked regions in 13 non-BRCA1/2 families in order to find novel susceptibility loci and high-penetrant genes. MATERIALS AND METHODS Genotyping with 540 fluorescently-labeled microsatellite markers located on the 23 chromosomes at 7.25 cM resolution was used for primary linkage analysis and an additional 40 markers were used for fine-mapping of loci with a logarithm of odds (LOD) or heterogeneity LOD (HLOD) score greater than one. Whole-exome sequencing data of 28 members from all 13 families were used for the bioinformatics sequence analysis on the linked regions of these families. RESULTS Linkage analysis identified three loci on chromosome 18q as a putative region of interest (overall LOD=1, HLOD=1.2). Sequencing analysis of the three linked regions on 18q and mutation prediction algorithms did reveal three probable damaging variants. CONCLUSION Overall, our study identified three weakly linked loci on 18q and three probable damaging variants of interest in the 13 families with breast cancer.
An Age- and State-Dependent Nonlinear Prognostic Model for Degrading Systems

Nonlinearity and stochasticity are two important factors contributing to the degradation processes of complicated systems, and thus have to be taken into account in stochastic degradation modeling based prognostics. However, current studies almost always focus on age-dependent stochastic degradation models, most of which are linear, or can be transformed into linear models. In this paper, we propose a general age- and state-dependent nonlinear degradation model for prognostics. In the presented model, a diffusion process with age- and state-dependent nonlinear drift and volatility coefficients is utilized to characterize the dynamics and nonlinearity of the degradation progression. To derive the estimated remaining useful life distribution, the considered diffusion process is first converted into a diffusion process with age- or state-dependent nonlinear drift but constant volatility through Lamperti transformation. Then, based on a well-known time-space transformation, we obtain an analytical approximated remaining useful life distribution in the concept of the first passage time. Furthermore, a maximum likelihood estimation method for unknown parameters in the concerned model is presented on the basis of closed-form approximated degradation state transition density functions by the Hermite-expansion method. An illustrative example is provided to show how the obtained results can be applied to a specific age- and state-dependent nonlinear degradation model. Finally, the presented model is fitted to bearing degradation data. Comparative results suggest the necessity of age- and state-dependent nonlinear degradation modeling in prognostics.
Distinct (cid:1) 2 Subunit Domains Mediate Clustering and Synaptic Function of Postsynaptic GABA A Receptors and Gephyrin

Modulation of the concentration of postsynaptic GABA A receptors contributes to functional plasticity of inhibitory synapses. The (cid:1) 2 subunitofGABA A receptorisspecificallyrequiredforclusteringofthesereceptors,forrecruitmentofthesubmembranescaffoldprotein gephyrin to postsynaptic sites, and for postsynaptic function of GABAergic inhibitory synapses. To elucidate this mechanism, we here have mapped the (cid:1) 2 subunit domains required for restoration of postsynaptic clustering and function of GABA A receptors in (cid:1) 2 subunit mutant neurons. Transfection of (cid:1) 2 (cid:1) / (cid:1) neurons with the (cid:1) 2 subunit but not the (cid:2) 2 subunit rescues postsynaptic clustering of GABA A receptors, results in recruitment of gephyrin to postsynaptic sites, and restores the amplitude and frequency of miniature inhibitory postsynaptic currents to wild-type levels. Analogous analyses of chimeric (cid:1) 2/ (cid:2) 2 subunit constructs indicate, unexpectedly, that the fourth transmembrane domain of the (cid:1) 2 subunit is required and sufficient for postsynaptic clustering of GABA A receptors, whereas cytoplasmic (cid:1) 2subunitdomainsaredispensable.Incontrast,boththemajorcytoplasmicloopandthefourthtransmembranedomainof the (cid:1) 2 subunit contribute to efficient recruitment of gephyrin to postsynaptic receptor clusters and are essential for restoration of miniature IPSCs. Our study points to a novel mechanism involved in targeting of GABA A receptors and gephyrin to inhibitory synapses.
Sexual differences in reproductive phenology and their consequences for the demography of Baccharis dracunculifolia (Asteraceae), a dioecious tropical shrub.

Patterns of phenological variation and reproductive investment were studied in the dioecious shrub Baccharis dracunculifolia DC (Asteraceae), and possible consequences on survivorship were evaluated. The sex ratio was determined in a natural field population (n = 921) of B. dracunculifolia in Belo Horizonte, Brazil. Fifty-two males and 56 females were sampled at random from this population. During the reproductive season of 1999, inflorescence production, shoot growth and mortality, and xylem water potential were recorded for each individual. The population sex ratio was male-biased (1.27 : 1, P < 0.05), and was associated with a higher mortality of female shoots (38.4 vs. 23.1 %, P < 0.05), and individuals (17.8 vs. 11.5 %, P < 0.1), despite lower water stress in female plants. Flowering phenology also differed between the sexes, with males producing more inflorescences, and earlier, than females. Owing to fruit maturation, the number of inflorescences supported by females was higher than that supported by males later in the reproductive season. This occurred during the dry season, and drought stress may have been responsible for the greater female mortality. Thus, the male-biased sex ratio in this population of B. dracunculifolia is probably due to different reproductive functions of males and females. Intersexual differences in reproductive phenology had consequences for plant demography.
The first 5years of clinical experience with laronidase enzyme replacement therapy for mucopolysaccharidosis I

Mucopolysaccharidosis I (MPS I, McKusick 25280) is caused by the deficiency or absence of the lysosomal enzyme, α-L-iduronidase (EC 3.2.1.76). This inherited disease causes progressive cellular, tissue and organ damage across the entire phenotypic spectrum. Disabling, multi-organ disease is the rule, and generally results in death between the first and fourth decades of life. Recently, laronidase (Aldurazyme® [Genzyme], a specific recombinant human α-L-iduronidase) became commercially available as long-term enzyme replacement therapy. Results from the Phase I/II and III extended clinical studies have shown that laronidase safely and effectively alleviates many systemic signs and symptoms of this progressive multisystemic disease. Clinically meaningful and sustained improvements in pulmonary function and functional capacity have been observed in Phase III study patients. Significant and sustained reductions in urinary glysosaminoglycan (GAG) excretion and hepatomegaly have also been observed. Improvements in sleep apnoea and joint range of motion occurred in patients with the most severe symptoms at baseline. Improvements in Disability Index scores as measured using the CHAQ and HAQ questionnaires were modest, which may have been related to the fact that these disability measuring tools are not disease-specific. Anecdotal reports of improvements in the performance of daily activities further add to the therapeutic benefits, as do case histories pointing at stabilisation or improvement of symptomatology in various organs, such as the eyes, heart, and muscles. With the availability of specific treatment, the importance of early recognition of the disease and appropriate therapeutic intervention has increased. The variability in clinical symptomatology is reviewed in detail and may allow for a better understanding of the diagnostic and therapeutic challenges. Results of the clinical trials and their initial extension periods, as well as the anecdotal experiences of physicians with laronidase in non-study settings, are discussed.
Renal cholesterol granulomas: identification and morphological pattern of development

Sir: In their recent paper in this Journal, Nast & Cohen (1985) suggested that the occurrence of renal cholesterol granulomas might be related to lipid disturbances in nephrotic syndrome. We recently identified cholesterol granulomas in a renal biopsy obtained at the time of percutaneous extraction of a renal calculus. The patient was a 66-year-old male who had been a non-insulin dependent diabetic for 4 years. He presented after routine urinalysis revealed the presence of blood and an intravenous urogram demonstrated a left renal staghorn calculus. Biochemically his diabetes was well controlled, there was no retinopathy, and estimations of serum urea, electrolytes, calcium, phosphate, uric acid and protein were within normal limits. There was no proteinuria. Renal biopsy showed early minor changes of diabetic glomerulosclerosis, early periglomerular fibrosis, focal tubular atrophy, moderate interstitial inflammation and fibrosis, hypertensive vascular changes, and an occasional small, well defined granuloma with clefts containing non-polarizing crystals, presumed to be cholesterol, adjacent to cortical tubules. The formation of cholesterol granulomas in this case was clearly unrelated to renal failure or proteinuria but may be related to the changes in lipid metabolism which occur in diabetes mellitus. However, in pericarditis associated with cholesterol granulomas only a proportion of cases have concomitant hyper-cholesterolaemia, and some have no apparent cause (McAllister & Ferrans 1983). Cholesterol granulomas in the nasal cavity are associated with chronic infection and a granulomatous response to intracellular cholesterol released after a cell breakdown (Perzin 1983), rather than by a fundamental defect in lipid handling. Such a view would be consistent with our case described above, since the presence of the staghorn calculus had caused patchy chronic interstitial inflammation and focal tubular atrophy. Renal cholesterol granulomas may be related to abnormalities in lipid metabolism or by analogy with other sites in the body, they may be a rare manifestation of chronic inflammatory damage to renal tissue.
The Dynamic Relationship between Corruption–Inflation: Evidence from Panel Vector Autoregression

This paper aims to explain the mixed causality nexus between corruption and inflation. For that, we apply a panel vector autoregression model on a large sample of 180 countries over the period 1996–2014. Using two corruption indexes and subsample estimations, results provide evidence that the inflation—corruption nexus is bidirectional. The causal effect is more important from corruption to inflation. Interactions remain significant but heterogeneous across subsamples with different income levels. The corruption effect is persistent only in low—middle income economies and its adverse effect on inflation is weaker in high-income economies. The two-way relationship between inflation and corruption reflects the inability to control inflation and the situation of the poverty trap in some countries.
Simulation Des Effets De La Récession Économique Mondiale En Guinée (Simulation of the Effects of the Global Economic Recession in Guinea)

French Abstract: La crise e�? conomique mondiale est simule�? e à travers une modification des prix des produits importe�? s et exporte�? s, des flux d’investissements e�? trangers, de l’aide publique au de�? veloppement et des transferts prive�? s internationaux. Quoique l’analyse re�? vèle une faible re�? percussion de la crise sur la croissance de l’e�? conomie guine�? enne, ses effets distributifs demeurent importants. En effet, le taux de croissance du PIB projete�? en 2009 est le�? gèrement infe�? rieur à celui de la re�? fe�? rence, tandis que ceux des pe�? riodes de stabilite�? et de reprise restent le�? gèrement supe�? rieurs à la re�? fe�? rence. La re�? duction des prix conse�? cutive à la re�? cession e�? conomique mondiale est favorable au bien-être de la population. Les me�? nages entrepreneurs enregistrent les plus fortes ame�? liorations de bien- être, suivis de ceux dont la principale source de revenu est peu expose�? e à l’e�? conomie mondiale - producteurs agropastoraux et salarie�? s du secteur public et parapublic. En revanche, la reprise e�? conomique est de�? favorable au bien-être de la population, en particulier aux cate�? gories qui profitaient davantage de la crise. English Abstract: The global economic crisis is simulated through changes in the prices of imported and exported products, foreign investment flows, official development assistance and international private transfers. Although the analysis reveals a weak impact of the crisis on the growth of the Guinean economy, its distributive effects remain important. Indeed, the growth rate of projected GDP in 2009 is slightly lower than that of the reference, while those of stability and recovery remain slightly above the reference. The price reduction resulting from the global economic recession is favorable to the well-being of the population. Entrepreneur households register the strongest welfare improvements, followed by those whose main source of income has little exposure to the world economy - agropastoral producers and employees in the public and parapublic sectors. On the other hand, the economic recovery is detrimental to the well-being of the population, especially to those who benefited more from the crisis.
[Expression and clinical significance of telomerase catalytic subunit gene in lung cancer and its correlations with genes related to drug resistance and apoptosis].

OBJECTIVE To investigate mRNA expression and prognostic significance of telomerase catalytic subunit (hTRT/hEST2) and its relations to apoptosis, proliferation and drug resistance in patients with lung cancer. METHODS Telomerase repeat amplification protocol-PCR(TRAP-PCR) and in situ hybridization were used to detect telomerase activity and expression of hTRT/hEST2 mRNA, respectively. The expression of bcl-2, c-myc, MRP, Neu, MDR1 at mRNA and protein levels was measured by means of RT-PCR and immunohistochemisty. In situ end labeling(ISEL) assay was used to evaluate apoptotic cells. RESULTS hTRT/hEST2 mRNA was detected in 41 of 56 NSCLC(73.2%) and 17 of 20 SCLC(85.0%), but it was not expressed in lung tissues adjacent to the tumor. Telomerase activity was postively correlated with the expression of hTRT/hEST2. In NSCLC, hTRT/hEST2 mRNA was positively correlated with bcl-2(r = 0.7327, P = 0.015), c-myc(r = 0.8263, P = 0.001), MRP(r = 0.3971, P = 0.003) and neu(r = 0.3208, P = 0.017), but not with MDR1 (r = 0.2415, P = 0.672). In SCLC, positive correlation was only found between hTRT/hEST2 and bcl-2 (r = 0.5663, P = 0.024). Correlation was positive between hTRT/hEST2 mRNA and Ki-67 expression but negative between hTRT/hEST2 and apoptosis both in NSCLC and SCLC. Multivariate Cox regression analysis showed that telomerase catalytic subunit hTRT/hEST2 and number of apoptotic cells were of prognostic significance in NSCLC. CONCLUSION As telomerase catalytic subunit expression shows correlations with MDR- and apoptosis-related genes and is of prognostic significance, telomerase in relation to multiple drug resistance deserves in-depth study.
Instruction cache aging mitigation through Instruction Set Encoding

The reliability of embedded processors fabricated using nanoscale technology nodes is threatened by accelerated transistor aging particularly, Bias Temperature Instability (BTI). In embedded memories such as instruction caches, BTI degrades the Static Noise Margin (SNM) of the memory cell, which in turn affects the stability of the stored value. Various bit flipping based solutions have been proposed to address BTI-induced aging of memory components. Nevertheless, the state-of-the-art techniques have considerable area and power overheads. In this paper, we propose an aging-aware instruction encoding technique to mitigate BTI-induced aging of instruction caches. Opcode, register and function code fields of an instruction are re-encoded so that the BTI-induced aging of the instruction cache is minimized. Simulation results show that the proposed technique achieves up to 40% SNM degradation improvement (equivalent to 47% MTTF improvement) with a negligible power overhead (0.1%).
Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

Thymic repertoire selection requires the expression of the alpha beta CD3 T-cell receptor (TCR) together with the coreceptors CD4 and CD8. The appearance of CD4 and CD8 on thymocytes is the hallmark of a complex maturation step, accompanied by downregulation of the interleukin 2 receptor (IL-2R) alpha chain, arrest of rearrangement (i.e., allelic exclusion) of the TCR beta-chain locus, a burst of cell divisions, and reduction in cell size. This maturation step is inhibited in TCR beta-chain-deficient mouse strains and may depend on surface expression of an immature TCR complex containing CD3 and TCR beta chains but no TCR alpha chain. Here we show that the CD4+8+ double-positive (DP) stage can be induced by treatment of fetal thymic organ cultures with anti-CD3 epsilon monoclonal antibodies in several TCR beta-chain-deficient mouse strains: severe combined immunodeficient (scid) mice, mice carrying a mutation in the recombination activating gene 1 (Rag-1), or mice carrying a deletion in the TCR beta-chain locus itself. These findings suggest that CD3 epsilon is expressed on the thymocyte surface independent of and prior to the TCR beta chain. The data are consistent with the notion that in wild-type mice the DP stage is induced by transmembrane signaling through an immature CD3-TCR beta-chain complex, which can be bypassed by crosslinking of CD3 epsilon alone.
Spheres of Educational Opportunity: A Mixed Methods Study Examining the Relationship Between Concurrent Enrollment Participation and Students' College Transition, Readiness, and Success

This dissertation examined high school concurrent enrollment participation in relation to the college transition, choice, readiness, and success of underrepresented student groups within the state of Colorado, as well as the implications of such programs on the equality of educational opportunities for this student population. Concurrent enrollment programs allow students an opportunity to engage in actual college classes while still in high school, with the intention of increasing college readiness and college graduation levels. However, while a burgeoning literature has argued for the promise of such programs, more rigorous, empirical studies are needed to understand the underlying effects of concurrent enrollment programs on underrepresented students’ college transition process, choice, readiness, and success outcomes. Incorporating a Policy Theory of Action framework, this dissertation answered the following research questions using both qualitative and quantitative methods. The qualitative portion of the dissertation explored: a) The types, and use, of resource and information networks that underrepresented students gain access to as a result of their participation in concurrent enrollment, b) How concurrent enrollment participation shapes underrepresented students’ attitudes, expectations, values, and their understanding of college and the worth of pursing a college degree and c) How underrepresented students’ concurrent enrollment experiences compare to other college preparation program alternatives found within pre-college settings? In the quantitative portion of the dissertation, a large-scale dataset from the Colorado Department of Higher Education was used to assess the relationship between underrepresented students’ participation in concurrent enrollment and the following: a) What types of institutions students attend for postsecondary education, b) Whether students will need academic remediation during their first year of postsecondary schooling, and 3) Students’ first year cumulative GPA. This research has implications for policymakers, scholars, educators, and practitioners who want to better understand underrepresented students’ experiences with concurrent enrollment programs.
An experimental study on homoharringtonine liposome and glaucoma filtration surgery.

PURPOSE To observe the inhibitory action of homoharringtonine liposome during the healing process of wounds in the filtering sites. METHODS Posterior sclerectomies were performed in 14 rabbits. Postoperatively one eye of each rabbit received subconjunctival injections of HH liposome and fellow eye received saline injection in a randomized masked fashion. RESULTS Fourteen days after operation the IOP of experimental eyes reduced significantly (P < 0.01) as compared with the controlled eyes, and the number of remaining filtering blebs increased noticeably (P < 0.05). Pathohistological examination revealed that the number of fibroblasts per square micron in the filtering sites and the thickness of the scars in the center of the filtering sites of the experimental eyes were less than those of the controlled eyes. No serious ocular toxic and side effects were found. CONCLUSION This experiment suggest that homoharringtonine liposome can markedly inhibit the scar formation of filtering sites after glaucoma filtering surgery, promote the formation of filtering blebs, and provide an experimental evidence for its clinical use in future.