Miracle-dz/UniFAR-FTUs huggingface dataset:
IoT Based Home Security

Internet of Things (IoT) allows real-world objects to be connected and managed through the internet. IoT is used to make any device smart and is thus a booming concept worldwide. Being a part of the era of the internet, it has become easier to experiment and develop new ideas. Many such ideas have been implemented, changing people’s lifestyles in general. Smart home technology is known to bring about more comfort and convenience at our homes. We have decided to stretch this concept out further to implement the concept of IoT into the security of our homes. The proposed model focuses on the security and ease of allowing access to the house. The leverage obtained by choosing this over other forms of home security is the ease of allowing access and monitoring our homes at any time and from anywhere. Our overall system is also focused on being made at a budget so that all sections of the society can experience this convenience and safety. In a world where technology is advancing at such a rapid rate, it is to be seen that everyone plays a part and stays up to date.
Property Data Estimation for Hemiformals, Methylene Glycols and Polyoxymethylene Dimethyl Ethers and Process Optimization in Formaldehyde Synthesis

Polyoxymethylene dimethyl ethers (OMEn) are frequently discussed as alternative diesel fuels, with various synthesis routes considered. OME3–5 syntheses demand significant amounts of thermal energy due to the complex separation processes that they entail. Therefore, innovative process designs are needed. An important tool for the development of new processes is process simulation software. To ensure sound process simulations, reliable physico-chemical models and component property data are necessary. Herein we present the implementation of a state-of-the-art thermodynamic model to describe the component systems of formaldehyde-water and formaldehyde-methanol using Microsoft® Excel (2010, Microsoft Corp, Redmond, WA, USA) and Aspen Plus®, (V8.8, Aspen Tech, Bedford, MA, USA) determine the deviation between the calculated results and experimental literature data, and minimize the deviation by means of parameter fitting. To improve the accuracy of the estimation of the missing property data of hemiformals and methylene glycols formed from formaldehyde using group contribution methods, the normal boiling points were estimated based on molecular analogies. The boiling points of OME6-10 are determined through parameter regression in accordance with the vapor pressure equation. As an application example, an optimization of the product separation of the state-of-the-art formaldehyde synthesis is presented that helps decrease the losses of methanol and formaldehyde in flue gas and wastewater.
Resistance to cancer immunotherapy in metastatic renal cell carcinoma

The prognosis of metastatic clear cell renal cell carcinoma (mccRCC) has changed dramatically over the years with the emergence of immune checkpoint inhibitors (ICI) used alone, or in combination with another ICI, or with vascular endothelial growth factor receptor tyrosine kinase inhibitor. Although major response rates have been observed with ICI, many patients do not respond, reflecting primary resistance, and durable responses remain exceptional, reflecting secondary resistance. Factors contributing to primary and acquired resistance are manifold, including patient-intrinsic factors, tumor cell-intrinsic factors and factors associated with the tumoral microenvironment (TME). While some mechanisms of resistance are common to several tumor types, others are specific to mccRCC. Predictive biomarkers and alternative strategies are needed to overcome this resistance. This review provides an overview of the major ICI resistance mechanisms, highlights the potential of the TME to induce resistance to ICI, and discusses the predictive biomarkers available to guide therapeutic choice.
Identification of ‘stress and Ca ++ metabolism related gene expression’ in wild Peromyscus exposed to environmental lead using combinatorial data from Mus cDNA microarrays and blood metabolites

We studied feasibility of using cDNA microarray to identify the biomarkers for toxicity of environmental lead (Pb) mixed with multiple effectors (mixed toxicants) in Peromyscus maniculatus, a rodent common in the North American continent. We used Mus muculus cDNA microarrays to identify a gene expression profile indicating toxicology of environmental lead, since the Peromyscus cDNA were not widely sequenced. We measured the effect of lead on differential gene expression in a laboratory strain of deer mice, Peromyscus maniculatus, and compared it to gene expression in wild deer mice (P. maniculatus) collected from a field site contaminated with lead, and an uncontaminated control field site. As expected, total blood hemoglobin (Hb) dropped with an increase in blood lead concentrations. The cDNA microarrays demonstrated similar differential expression of genes in livers of lead contaminated mice in the laboratory and mice in the field. Genes affected included nuclear subunits of mitochondrial cytochrome oxidases and NADH dehydrogenases, transcripts of Hsp 90aa1, protein phosphatase 2, calmodulin 1, Annexin A7 and Sparc. Identification of ‘putative stress related biomarker genes’ of liver proIdentification of ‘stress and Ca metabolism related gene expression’ in wild Peromyscus exposed to environmental lead using combinatorial data from Mus cDNA microarrays and blood metabolites SDRP Journal of Earth Sciences & Environmental Studies (ISSN: 2472-6397) DOI: 10.25177/JESES.4. 1.RA. 438 Research
Novel Approaches For The Identification And Targeted Clearance Of Senescent Cells, As A Therapeutic Strategy For Senescence-Related And Age-Related Diseases

Cellular senescence is a state of permanent cell cycle arrest in which cells remain metabolically active, adopting characteristic phenotypic changes. Although senescence is a potent tumour suppressor mechanism, the accumulation of senescent cells in tissues over time has been shown to contribute to several pathophysiological conditions, including fibrosis, diabetes, cancer, Alzheimer’s disease and ageing, making the targeting of these cells a potentially relevant therapeutic strategy for fighting these pathologies. Clearing senescent cells has been reported to protect against cancer and the onset of age-related pathologies. Furthermore, preventing the accumulation of senescent cells in tissues also prolonged healthspan and lifespan in mouse models. Currently available markers of senescence, however, lack specificity and selectivity, limiting their therapeutic use. This underscores the need for senescence-specific markers that could be targeted and translated into clinical use. Here, we describe the application of molecularly imprinted polymer nanoparticles (nanoMIPs) designed to target an extracellular epitope of B2MG, a membrane protein recently characterized as a novel marker of senescence, and propose this as a novel tool for the specific detection of senescent cells both in vitro and in vivo. We further show that B2MG nanoMIPs laden with a toxic payload selectively kill senescent cells in culture. Consistent with this, we show that antibody-drug conjugates (ADCs) against B2MG selectively kill senescent cells in culture. We also demonstrate that Ibrutinib, a clinically approved chemical inhibitor of BTK, reduced the accumulation of senescent cells in vivo, prolonging lifespan and healthspan in a mouse model of progeria. Zmpste24-/- mice treated with Ibrutinib showed an increase in maximum lifespan and a reduction in age-related fitness decline, evidenced by their increased physical strength, reduced anxiety and better long-term memory, with no evidence of spontaneous tumour formation. The results from this research altogether highlight new strategies for reducing the accumulation of senescent cells in vivo, which could find translational application in the clinical management of senescence-related and age-related ailments.
Medium of instruction in Hong Kong secondary schools: integrating L1 in English-medium classrooms

ABSTRACT Content and language integrated learning (CLIL) has become popular in bilingual educational contexts around the world. In Hong Kong, medium of instruction (MOI) in secondary schools has received great attention among teachers, students and parents over the years. After the handover of Hong Kong to China, the local government launched the mother-tongue language policy. However, many parents believe that English as a medium of instruction (EMI) secondary schools are better than Chinese (Cantonese) as a medium of instruction (CMI) schools. After years of discussion, the government implemented a ‘fine-tuning’ language policy which allows more schools to offer EMI curriculum. These development of language policy have prompted policy makers and educators to rethink whether monolingual instructional approach benefits students the most in CLIL classrooms. Reviewing the language policy in Hong Kong, this paper suggests that English-medium CLIL programmes, with purposeful use of Cantonese, should be promoted in Hong Kong secondary schools.
Screening and selection: Applications for vitamin biosynthesis in Escherichia coli

Microbial cell factories offer new and sustainable production routes for high-value chemicals. However, identification of high producers within a library of clones remains a challenge. When product formation is coupled to growth, millions of metabolic variants can be effectively interrogated by growth selection, dramatically increasing the throughput of strain evaluation. While growth-coupled selections for cell factories have a long history of success based on metabolite auxotrophies and toxic antimetabolites, such methods are generally restricted to molecules native to their host metabolism. New synthetic biology tools offer the opportunity to rewire cellular metabolism to depend on specific and non-native products for growth. Graphical abstract A diverse library of producers is characterized for production variants. Suitable selection systems allow growth only above the threshold, reducing the original library to the top producers.
The influence of organic matter on the strength development of cement-stabilized marine soft clay

Abstract The organic matter within clay soil is one of the important factors affecting its engineering characteristics. In this study, the influence of organic matter on the strength evolution of cement-stabilized marine soft clay is evaluated by scanning electron microscopy (SEM) and unconfined compressive strength (UCS) testing. The experimental results show that the after-curing clay water content of the specimens increased with the organic matter content. However, the after-curing unit weight decreased with the organic matter content. The strength decreased with the increase in the amount of organic matter. The strength loss (SL) increased with the organic matter content. A new mathematical model was determined and then used to quantitatively analyze the strength of the investigated samples. A relationship between the strength and organic matter content was established. The evaluation of the accuracy of this new strength model was carried out by comparing the predicted values and measured values, and the results indicated that the deviation was mostly within 10%. Finally, the microscopic changes of the sample surface and influencing mechanism of the organic matter were revealed through SEM. A high soil strength is mainly due to a relatively low porosity, a dense microstructure and the formation of hydration products.
Direct Electrochemical Oxidation of Dihydronicotiamide AdenineDinucleotide （NADH） at An Ordered Carbon Nanotubes Electrode

An ordered carbon nanotubes (CNTs) film, which was template-synthesized within the porous of an alumina template, modified glassy carbon electrode is fabricated. The electrode exhibits potent electrocatalysis for NADH oxidation in PBS (pH 6.8) with a diminution of the overpotential of more than 600 mV. The anodic peak current increases linearly with NADH concentration from 2×10-5 mol/L to 1×10-3 mol/L with the detection limit of about 5×10-7 mol/L.
Trophic interaction between striped marlin and swordfish using different timescales in waters around Baja California Sur, Mexico

ABSTRACT Isotopic niche and resource partitioning were examined between striped marlin (Kajikia audax) and swordfish (Xiphias gladius) using stable isotope ratios from spine bone and muscle samples. The δ13C (13C/12C) and δ15N (15N/14N) values were measured in annual growth bands from fin spines and muscle collected from striped marlin and swordfish off Baja California Sur to evaluate the trophic interaction between these two species, the relative contribution of the main prey and the isotopic niche within two different timescales. Mean trophic level (TL) values were different when tissues were compared with the highest value found in muscle samples from K. audax. When TL was analysed in all growth bands for both species, no changes were detected throughout time, suggesting only minor differences in feeding habits between these species. We determined that Dosidicus gigas, Sthenoteuthis oualaniensis, and Ancistrocheirus lesueurii were the most important prey for both species, but the relative contribution of each of them to the diet differed. There is likely no trophic overlap between K. audax and X. gladius off Baja California Sur, as K. audax occupied a larger isotopic niche with more diverse prey than X. gladius.
Study on the patterns of semen analysis in infertile males at a tertiary setup in Devanahalli

Background: Infertility is a stigma in our social environment where 40-50% is due to male infertility. Aim: To evaluate the different patterns of semen abnormalities seen with associated factors. Methods: A prospective study was carried out at the Pathology Laboratory on seminal fluid with male factor as the cause for infertility. Semen samples were analyzed by manual method, using WHO guidelines. Result: Out of 110 samples studied, 74 were Normozoospermia with normal semen parameters and 36 had abnormal semen parameters. Oligoasthenozoospermia was more evident (23), followed by Oligozoospermia (7), Asthenozoospermia (3), Azoospermia (2) and Teratozoospermia (1). Conclusion: Semen analysis remains the cornerstone for evaluating infertility in males. More than the seminal volume given importance; the count, motility and morphology are the most valuable factors of male infertility. Negative lifestyle has a significant impact on semen parameters especially with cigarette smoking and to some extent alcohol consumption.
Overview and Applications of RNA Silencing in Fruit Crops

RNA silencing has recently gain momentum in the scientific world mainly due to its sequencing-specific gene inactivation that is conserved in among various organism including animals and plants. In fruit crops, various mechanism such as virus-induced gene silencing (VIGS), DNA methylation, Ribonucleic acid interference (RNAi) and Anti-sense mediated gene silencing has been reported. These epigenetic regulatory mechanisms are highly useful in fruit crops as it suppresses or silences gene responsible for undesirable morpho-agronomic characters.
Determination of Total Phenolic Content in Almonds After Lipid Removal or After Deproteinization

The classical method for polyphenols extraction requires long time and large amounts of reagents used. Our objective was to compare the results obtained using this method with results obtained using a direct method. The research was made on almonds cultivated in Palma de Mallorca, Spain. The polyphenol content of almond kernels were examined in two different ways: polyphenols extraction after lipid removal or after sample deproteinization. Commune and selected kernels were provided from Spain. One gram of almonds with 10 mL water were homogenized. In the first case,10 mL were colected and extracted two times with hexane to remove lipids,first extraction all night long, and second extraction, 4-5 h. Polyphenols were extracted from aqueous phase with HCl:H2O:methanol during 16 h at 4 °Ϲ. The methanolic extract was retained and evaporated under nitrogen and the residue was reconstituted in 10 mM phosphate buffer. In the second case, the homogenate was deproteinized with acetone. Total phenols were assayed colorimetrically with the Folin-Ciocalteu. The calibration curve was made using pyrogallol. The results showed an effect for obtaining method, but not for almond varieties. Using extraction to remove lipids may cause losses in total polyphenols content while deproteinization avoides these polyphenol losses and reduces time and reagents.
Photochemistry of the uranyl ion in colloidal silica solution

Uranyl acetate, once adsorbed onto a silica particle, exhibits an extremely long excited-state lifetime with t/sub 1/2/ approx. 440 . mu.s as compared to 11 . mu.s in water. The fluorescence spectrum is slightly blue shifted, and the transient absorption spectrum is quite different, consisting of only one peak on the silica but two peaks in water. The rate constants for several quenchers are determined and used to probe the nature of the silica surface. The interactions of the uranyl ion with various surfactants are also discussed, which further illustrate the uniqueness of the uranyl-silica system. A revised energy diagram is presented to account for the various spectral features encountered.
Variable Definition and Independent Components

In the causal modelling literature, it is well known that “ill-defined” variables may give rise to “ambiguous manipulations” (Spirtes and Scheines, 2004). Here, we illustrate how ill-defined variables may also induce mistakes in causal inference when standard causal search methods are applied (Spirtes et al., 2000; Pearl, 2009). To address the problem, we introduce a representation framework, which exploits an independent component representation of the data, and demonstrate its potential for detecting ill-defined variables and avoiding mistaken causal inferences.
Behavioral Ecology of the Yucatan Jay

Prominent among bird groups possessing highly developed cooperative social systems are the New World jays (Brown 1974). Recent studies by Brown (1972) of Aphelocoma ultramarina and Woolfenden (1973, 1975) of Aphelocoma coerulescens coerulescens have revealed a high degree of sociality in those forms. Cooperative breeding also occurs among the blackand-blue jays of the subgenus Cissilopha (genus Cyanocorax, fide Hardy 1969), as recently shown by Hardy (1976) for the northern form of the San Blas Jay, Cyanocorax sanblasiana nelsoni, of western Mexico and Bushycrested Jay, C. melanocyanea, of Central American highlands. As our results presented here will demonstrate, the Yucatan Jay, C. yucatanica, is also highly social and a cooperative breeder.
Performance of Existing Predictor of SubCellular Localization of Long Non-Coding RNA on the New Database

Long non-coding RNAs (lncRNAs) have important functions in the regulation of life activities at multiple levels, such as chromatin remodeling, transcriptional and posttranscriptional regulation. They have different functions according to the different locations in the cell. Therefore, it is important to obtain the sub-cellular location information to understand the functions of lncRNAs. However, the biochemical experimental way of sub-cellular localization requires a long period and high cost. Currently, many methods of predicting sub-cellular location based on the machine learning and deep learning have been developed to ease the difficulty in detecting the sub-cellular location. We fetched the latest version RNA database to evaluate the performance of existing predictors, lncLocator and iLoc-lncRNA.
Development of nanoemulsions containing penciclovir for herpes simplex treatment and a liquid chromatographic method to drug assessment in porcine skin layers

A successful formulation (penciclovir hydrogel nanoemulsion - HN) to be used in transdermal drug delivery route to treat herpes simplex virus was developed and an analytical method to quantify penciclovir (PCV) in porcine ear skin was stablished and validated. PCV nanoemulsions were prepared by high pressure homogenization and presented spherical mean droplet size 180 nm. The association efficiency and zeta potential were 87% and– 27 mV, respectively. The bioanalytical method developed showed specificity for the interferences from the skin matrixes (epidermis and dermis) and the linearity was in the range 0.1 – 25 μg/mL of drug, The mean recovery data for the three levels tested were 95.2% for the epidermis and 97.3% for the dermis and adequate results were obtained for repeatability and inter-day precision. In vitro percutaneous absorption studies with the PCV nanoemulsion and a market cream were conducted employing the porcine skin.The cumulative amounts of PCV permeated from cream and HN, 8 h after dosing, were 2.60 and 4.15 μg/cm², respectively, representing a quite higher flux and a much higher permeability coefficient for the developed formulation. It can be concluded that HN provide a good skin targeting effect and may be a promising carrier for topical delivery of penciclovir.
Hierarchical temporal prediction captures motion processing from retina to higher visual cortex

Visual neurons respond selectively to specific features that become increasingly complex in their form and dynamics from the eyes to the cortex. Retinal neurons prefer localized flashing spots of light, primary visual cortical (V1) neurons moving bars, and those in higher cortical areas, such as middle temporal (MT) cortex, favor complex features like moving textures. Whether there are general computational principles behind this diversity of response properties remains unclear. To date, no single normative model has been able to account for the hierarchy of tuning to dynamic inputs along the visual pathway. Here we show that hierarchical application of temporal prediction - representing features that efficiently predict future sensory input from past sensory input - can explain how neuronal tuning properties, particularly those relating to motion, change from retina to higher visual cortex. This suggests that the brain may not have evolved to efficiently represent all incoming information, as implied by some leading theories. Instead, the selective representation of sensory inputs that help in predicting the future may be a general neural coding principle, which when applied hierarchically extracts temporally-structured features that depend on increasingly high-level statistics of the sensory input.
Fate of Abstracts Presented at the Korean College of Rheumatology Annual Scientific Meetings

Yong-Gil Kim, Chan-Bum Choi, Seong Wook Kang, Jinseok Kim, Young Dae Kim, Jaejoon Lee, Myeung Su Lee, Young-Ho Lee, Jun-Ki Min, Min-Chan Park, Sung Hoon Park, Yong-Wook Park, Seung Wook Lee, Jae-Bum Jun Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Department of Internal Medicine, Jeju National University Hospital, Jeju, Department of Pediatrics, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Division of Rheumatology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Division of Rheumatology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Division of Rheumatology, Department of Internal Medicine, Arthritis and Autoimmunity Research Center, Catholic University of Daegu School of Medicine, Daegu, Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Department of Urology, Hanyang University Guri Hospital, Guri, Korea