Miracle-dz/UniFAR-FTUs huggingface dataset:
Strategy as evolutionary path. Five higher education institutions on the move

Strategy in universities has been a controversial issue in the last decades of scholarly debate, at least in relation to continental European models. On one side higher education institutions have been considered specific organizations whose essential nature hinders strategy and the coordination and control functions thereby entailed. On the other side, new public management reforms requiring strategic capability to be developed have been the object of critical scrutiny with respect to their underlying ideology and their implications for the functioning of academia. Against this backdrop, little empirical research has been conducted in order to understand how universities develop their strategy and what this consists of at the organizational level. This research aims at contributing to this discussion by providing an analytical framework in order to observe strategy and its dimensions and, accordingly, by presenting the analysis of five higher education institutions. Strategy is conceived as a coherent pattern of actions at the organizational level, which must be recognized as such by relevant actors. This definition allows us to look retrospectively at the combination of deliberate and emergent strategies that produce organizational undertaking as a continuous stream of actions that are consistent over time. Two central dimensions of strategy are considered: actors’ interactions in producing strategic organizational actions and the impact of strategy on university positioning. Strategy is the result of several actors’ interests and endeavors which eventually converge: in fact, deliberate strategies may be modified, integrated or substituted by emergent strategies, continuously developed by central administrators, academics and public authorities advocating their interests and responding to new environmental conditions. Furthermore, strategy impacts the position of universities within their national higher education system, influencing its trajectory, its linkages and resource acquisition in relation to other higher education institutions and public authorities.
Dynamics of organic and inorganic carbon across contiguous mangrove and seagrass systems (Gazi Bay, Kenya)

forest and the dense seagrass beds. The latter is consistent with the reported export of mangrove-derived material, which is efficiently trapped in the adjacent seagrass beds. There were significant net inputs of POC and dissolved organic carbon (DOC) along the Kidogoweni salinity gradient, for which the d 13 CPOC signatures were consistent with those of mangroves. DOC was the dominant form of organic carbon in both mangrove and seagrass beds, with DOC/POC ratios typically between 3 and 15. Dynamics of dissolved inorganic carbon in the creeks were strongly influenced by diagenetic C degradation in the intertidal mangrove areas, resulting in significant CO2 emission from the water column to the atmosphere. Although highest partial pressure of CO2 (pCO2) values and areal CO2 flux rates were observed in the mangrove creeks, and the water column above the seagrass beds was in some locations a net sink of CO2, most of the ecosystems’ emission of CO2 to the atmosphere occurred in the seagrass beds adjacent to the mangrove forest. The presence of dense seagrass beds thus had a strong effect on the aquatic biogeochemistry, and resulted in trapping and further mineralization of mangrove-derived POC, intense O2 production and CO2 uptake. The adjacent seagrass beds provide a large area with conditions favorable to exchange of CO2 with the atmosphere, thereby limiting export of mangrove-derived organic and inorganic carbon toward the coastal ocean.
6-Phosphogluconolactonase Mutants of Escherichia coli and a Maltose Blue Gene

Mutants lacking an enzyme of the oxidative branch of the hexose monophosphate shunt, 6-phosphogluconolactonase (pgl), have been selected as a new class of glucose-negative derivatives of a phosphoglucose isomerase (pgi) mutant. Glucose negativity is not as complete as in mutants lacking phosphoglucose isomerase and glucose-6-phosphate dehydrogenase. Pgi+, pgl− strains have been constructed by transduction and grow almost normally on glucose. Genetic mapping shows that pgl lies between chlD and att-λ, in the same position as and identical with a blu gene described by Adhya and Schwartz. These blu mutants grown on maltose were recognized by their property to turn blue after treatment with iodine. It is not known how phosphogluconolactonase deficiency causes this reaction; it might be related to accumulation of 6-phosphogluconolactone.
What the white goods sector should understand in order to join the Internet of Things ecosystem in the connected home

— The implications of the Internet of Things (IoT) regarding business can be observed under multiple perspectives. Some of these perspectives involve the development of new products, innovation, inter-firm collaboration or competition. However, in this research, the problem is analysed from the perspective of the IoT ecosystems in the connected home, which tries to identify the element structure in order to maximize the information value creation for the white goods sector. This document explores the evolution of the Internet of Things in the home with a business focus point in terms of information value. This is based on an extensive review of literature while analysing the phenomena incidence of industry and organizations. Likewise the challenges and opportunities that the household appliance companies represent are visualized, the business model framework is used in order to contextualize the problem, find a knowledge gap and integrate the stakeholders conceptions about the Internet of Things.
Internet-only Banks: An Introductory Overview

금융과 정보통신기술(ICT)의 융합을 의미하는 핀테크의 등장과 함께, 국내 최초의 인터넷전문은행인 케이뱅크와 카카오뱅크가 출범하였다. 대표적인 ICT 기업이 설립하여 운영하는 인터넷전문은행은 자사의 모바일 플랫폼을 통해 시공간의 제약이 없는 완전한 비대면 거래를 지향한다. 또한, 파격적인 금리 혜택을 제공하고 다양한 고객 서비스를 제시하며 기존 은행의 전통적 영업방식을 변화시키고, 핀테크와 인공지능기술 및 로보어드바이저를 활용한 차세대 금융서비스를 구상하고 있다. 그러나, 산업자본의 은행 소유지분을 제한하는 은산분리의 규제, 지원정책과 관련 제도의 미비, 혁신성의 부재등으로 인하여 인터넷전문은행의 발전은 정체될 수도 있다. 본 논문은 국내 인터넷전문은행의 현황을 조사하고, 해외 인터넷전문은행의 사례와 제도를 분석하여, 인터넷전문은행 산업의 방향을 개괄적으로 제시한다. 해외의 주요 인터넷전문은행은 적절한 규제와 지원정책 및 제도하에서, 계열사와의 협업을 통해 시너지를 창출하거나 ICT 기업이 보유한 자본과 기술력으로 핀테크를 적극적으로 활용하여 해당 산업의 발전을 주도하며, 전통적 은행과는 차별화된 새로운 금융서비스를 제공한다. 인터넷전문은행 산업의 지속적 발전과 금융산업 전반에 요구되는 혁신과제에 대응하기 위해서는, 적절한 규제는 필요하되, 잠재적 기술력을 보유한 기업들에 의해 핀테크와 신기술의 활용이 적극적으로 논의될 수 있는 제도와 환경이 조성되어야 한다.
Avaliação da microinfiltração bacteriana nas interfaces entre pilares e implantes

The aim of this study was to evaluate, in vitro, the bacterial leakage between implant and abutment comparing three kinds of implantabutments connections: extern hexagon (EH), indexed intern hexagon (IIH) and morse-taper (MT). Under sterile controlled conditions, the tip of the abutment screw was inoculated with Escherichia coli culture and then the abutment was placed in position and tightened (20N/cm). The specimen was discarded if an external contamination of the outer surface was observed. Each specimen was incubated in a glass tube containing 2mL of sterile TSB medium at 37C. The growth of E. Coli in the medium was registered every 24h. Once the sample showed cloudy broth, it was individually plated on TSA plates and incubated in an anaerobic chamber at 37C for 24h, in order to observe the bacterial growth. Gram test was performed both in the medium and in the culture to certify the presence of E. Coli (Gram negative). After 7 days, each test specimen was sampled using a sterile paper point which was incubated in TSA plates and incubated in anaerobic chamber at 37C for 24h, to verify bacterial viability. Samples that did not show bacterial viability in the end of the study were eliminated from the final results. After that, there were 38 EH samples, 40 IIH samples and 41 CM samples. The results, in %, of bacterial leakage, were statistically evaluated by multiple comparisons for proportion. The survival curves were analyzed by Kaplan-Meyer method and compared by statistical test of Log-Rank. There was no statistical difference among EH (10,53%), IIH (4,88%) e MT (7,50%). The three survival curves did not differ (p>0.005). It was conclude that the bacterial leakage occurred in a similar way for the three kinds of implant-abutment interface, no matter the assembly configuration.
Public Reporting of Hospital-Specific Breastfeeding Measures

Background: Establishing breastfeeding in the first days of an infant’s life is important for longer term success in breastfeeding. In 2009, New York State (NYS) was the second state to require maternity care facilities to collect infant feeding information and to publicly disseminate hospital-specific infant feeding statistics. Public reporting of these statistics as performance measures is a strategy to prompt hospitals to improve breastfeeding support. Objective: This qualitative study sought to explore how maternity care administrators and clinical staff responded to the mandate for publicly reported performance measures and whether they used this information to improve maternity care practices. Methods: This study used a stratified random sample of NYS hospitals with maternity care units. Participants were recruited by email and telephone calls. A total of 25 hospitals participated in the study, and 37 hospital administrators and staff completed in-depth interviews by telephone. The interviews were analyzed using an explanatory framework in NVivo 8. Results: Publicly reported hospital-specific breastfeeding measures increased attention to breastfeeding performance. Hospital administrators and staff reported comparing their relative rankings to other hospitals in the state. Some hospitals used publicly reported breastfeeding measures to monitor performance, whereas others were prompted to generate additional measures for more frequent monitoring. Hospitals with relatively low breastfeeding statistics took certain actions to improve their maternity care practices to support breastfeeding. Limitations of the usefulness of publicly reported measures were reported by interview participants. Conclusion: Publicly reported, hospital-specific breastfeeding measures may prompt hospitals to monitor and improve maternity care practices related to supporting breastfeeding.
Computational Modelling of Poetry Generation

Poems are particular well-crafted formulations of certain messages that satisfy constraints on their form as well on their content. From an engineering point of view, the ability to optimize the combination of form and content is a very desireable feature to be able to model. The present paper reviews a number of efforts at modelling poetry generation computationally, and it brings together insights from these efforts into a computational model that allows integration of a number of AI technologies combined together according to control structures compatible with observed human behaviour. The relation of this computational model with existing cognitive models of the writing task, and with models of computational creativity is discussed.
Effect of Palatal Implants on Continuous Positive Airway Pressure and Compliance

Objective. Determine if the Pillar palatal implant system reduces continuous positive airway pressure (CPAP) pressure and improves patient compliance with CPAP therapy. Study Design. Randomized, double-blind, placebo-controlled study. Setting. Four geographically dispersed tertiary sleep disorder referral centers. Methods. Subjects with mild to moderate sleep apnea dissatisfied with CPAP because of pressure-related complaints were randomized to receive Pillar implants or a sham procedure performed in double-blind fashion. Active and sham groups were compared for changes in therapeutic CPAP pressures (primary outcome) with a 90-day follow-up sleep study and CPAP compliance (secondary outcome) with a 90-day smart card report. Results. Twenty-six subjects were randomized to Pillar implants and 25 to a sham implant procedure. There were no differences between groups with regard to demographics and baseline parameters. Both sham and active groups had reduced mean CPAP pressure (−1.1 vs −0.5 cm H2O) with no difference between groups (P = .32) at 90-day follow-up. In addition, there was no difference in average daily CPAP use between groups (P = .80). Both groups experienced improvements in Epworth sleepiness scores and Functional Outcome of Sleep Questionnaire scores at 90 days with no differences between groups. The active group reported significantly higher CPAP satisfaction scores than the sham group (P = .04). Conclusion. Pillar implants do not significantly reduce CPAP pressure or increase CPAP compliance compared to sham controls but may subjectively improve CPAP satisfaction. These findings do not presently support the use of Pillar implants as an adjunctive treatment to improve CPAP compliance.
Recent advances in nanofabrication techniques for SERS substrates and their applications in food safety analysis

ABSTRACT The ability to analyze food safety and quality in a quick, sensitive, and reliable manner is of high importance in food industry. Surface-enhanced Raman scattering (SERS), which is popular for its significant enhancement, excellent sensitivity, and the fingerprinting ability to identify special molecules, has shown vast potential for rapid detection of chemical constitutes, chemical contaminants, and pathogens in food sample. For SERS, the enhancement of Raman signals is related to not only the SERS-active substrates, but also the interactions between sample and substrates. In the current review, colloidal and solid surface-based substrates are briefly described, fabrication techniques for SERS substrates are presented, and applications of SERS for food matrixes, correlation between substrates and food samples are also introduced. Finally, some outlook on further developments is presented. The current review is therefore intended to provide a comprehensive overview on the nanofabrication of SERS substrates, and the potential of applying SERS as an important food analysis platform.
Hipertrofia cardíaca: mecanismos moleculares

A hipertrofia cardiaca e, na maioria dos casos, um processo adaptativo do miocardio a sobrecargas hemodinâmicas cronicas e, paradoxalmente, constitui-se em fator de risco de morbi-mortalidade cardiovascular. Basicamente a hipertrofia cardiaca decorre do aumento das dimensoes do cardiomiocitos, no entanto, proliferacao de tecido conjuntivo intersticial tambem e observada, dependendo da intensidade do processo hipertrofico. O crescimento hipertrofico dos cardiomiocitos decorre de aumento quantitativo das proteinas estruturais e contrateis, mas durante o estabelecimento da hipertrofia sao tambem re-expressos genes caracteristicos da vida fetal como algumas isoformas de proteinas contrateis, o fator natriuretico atrial e a enzima conversora da angiotensina I, o que confere caracteristicas fenotipicas de imaturidade a celula hipertrofica. Multiplos mecanismos podem contribuir para o desenvolvimento da hipertrofia, mas sua estreita relacao com a carga hemodinâmica imposta ao coracao indica a predominância de fatores mecânicos, como tensao de deformacao, como os principais estimulos para o desenvolvimento e a manutencao da hipertrofia dos cardiomiocitos. Mecanismos associados ao citoesqueleto e canais ionicos sensiveis ao estiramento sao propostos como responsaveis pela transducao mecano-bioquimica em miocitos cardiacos. Multiplas vias intracelulares que envolcem GTPases, quinases ativadas por mitogenos e fatores de transcricao como o MEF2, NFAT3 e GATA4 estao envolvidadas no desenvolvimento da hipertrofia cardiaca. Portanto, a hipertrofia cardiaca e um fenomeno adaptativo complexo do miocardio que depende, para sua instalacao, da mobilizacao de multiplos mecanismos de sinalizacao envolvidos no crescimento celular. (AU)
Editorial: The intertwined play of governance, regulation, financial information and disclosure – Suggestions for further research

We are pleased to present the first issue of the Journal in 2019. The current issue of the Journal focuses on some key topics that spread from the description of the forthcoming globalization scenario, to the investigation of banks’ and financial institutions’ governance mechanisms within specific countries, and finally to the analysis of the interlocking network phenomenon in a specific country’s stock market.
Effect of sinapic acid on 1,2 dimethylhydrazine induced aberrant crypt foci, biotransforming bacterial enzymes and circulatory oxidative stress status in experimental rat colon carcinogenesis.

AIM This study was aimed to investigate the effect of sinapic acid (SA) on 1,2-dimethylhydrazine (DMH) induced experimental rat colon carcinogenesis. MATERIALS AND METHODS Rats were assorted into six groups, group 1 served as control, group 2 received SA (80 mg/kg b.w.) post orally every day until the end of the experimental period of 16 weeks, groups 3-6 rats were injected DMH (20 mg/kg b.w.) subcutaneously once a week for first four weeks. In addition, groups 4-6 rats received different doses of SA (20, 40 and 80 mg/kg b.w.). RESULTS Our results showed that DMH induced rats revealed significantly increased ACF development and multiplicity, which were significantly inhibited on supplementation with SA. Moreover, elevated levels/activities of circulatory oxidative stress markers, faecal and colonic mucosal bacterial enzymes were observed in DMH exposed rats, which were diminished on supplementation with SA. CONCLUSION Overall, our findings revealed that supplementation with SA offers significant protection against DMH induced rat colon carcinogenesis and the effect of SA at the dose of 40 mg/kg b.w. was more pronounced as compared to the other two doses. (Tab.5, Fig. 3, Ref. 46)
Rising Cost of Cancer Pharmaceuticals: Cost Issues and Interventions to Control Costs

The rising cost of pharmaceuticals and, in particular, cancer drugs has made headline news in recent years. Several factors contribute to increasing costs and the burden this places on the health care system and patients. Some of these factors include costly cancer pharmaceutical research and development, longer clinical trials required to achieve drug approval, manufacturing costs for complex compounds, and the economic principles surrounding oncology drug pricing. Strategies to control costs have been proposed, and some have already been implemented to mitigate cancer drug costs such as the use of clinical treatment pathways and tools to facilitate cost discussions with patients. In this article, we briefly review some of the potential factors contributing to increasing cancer pharmaceutical costs and interventions to mitigate costs, and touch on the role of health care providers in addressing this important issue.
North Atlantic Climate Response to Lake Agassiz Drainage at Coarse and Ocean Eddy-Permitting Resolutions

AbstractThe North Atlantic climate response to the catastrophic drainage of proglacial Lake Agassiz into the Labrador Sea is analyzed with coarse and ocean eddy-permitting versions of a global coupled climate model. The North Atlantic climate response is qualitatively consistent in that a large-scale cooling is simulated regardless of the model resolution or region of freshwater discharge. However, the magnitude and duration of the North Atlantic climate response is found to be sensitive to model resolution and the location of freshwater forcing. In particular, the long-term entrainment of freshwater along the boundary at higher resolution and its gradual, partially eddy-driven escape into the interior leads to low-salinity anomalies persisting in the subpolar Atlantic for decades longer. As a result, the maximum decline of the Atlantic meridional overturning circulation (AMOC) and the ocean meridional heat transport (MHT) is amplified by about a factor of 2 at ocean eddy-permitting resolution, and the re.
The modulating effects of proinflammatory cytokines interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha), and immunoregulating cytokines IL-10 and transforming growth factor-beta (TGF-beta), on anti-microbial activity of murine peritoneal macrophages against Mycobacterium avium-

We assessed the roles of proinflammatory cytokines IFN-gamma and TNF-alpha, and immunoregulatory cytokines IL-10 and TGF-beta in the modulation of the anti-microbial activity of murine peritoneal macrophages against Mycobacterium avium-intracellulare complex (MAIC). First, both IFN-gamma and TNF-alpha significantly reduced the bacterial growth in macrophages, indicating that these cytokines participate in up-regulation of macrophage anti-MAIC function. Second, although MAIC-infected macrophages produced substantial amounts of IL-10 and TGF-beta, neutralization of endogenous IL-10 and TGF-beta with anti-IL-10 and anti-TGF-beta antibodies, respectively, did not affect the intracellular growth of MAIC in macrophages from mice with BcgS (MAIC-susceptible) or BcgI (MAIC-resistant) genotype, regardless of the virulence of test MAIC strains. The same result was also obtained for macrophages stimulated with IFN-gamma or TNF-alpha. Third, in MAIC-infected mice, the growth of organisms at the sites of infection (lungs and spleens) was not affected by administration of anti-IL-10 or anti-TGF-beta antibodies. These findings indicate that, in the case of mice, endogenous IL-10 and TGF-beta are essentially ineffective in down-regulating macrophage anti-MAIC functions not only in vitro but also in vivo.
Vaccines Against Francisella Tularensis

Abstract: Francisella tularensis is one of the most pathogenic pathogens known, especially when disseminated as a small particle aerosol. Because of this, it was developed into a biological warfare agent by several states during the 20th century. Nowadays, concerns remain about the potential of this pathogen to cause widespread disease, tularemia, in the hands of terrorists. This has resurrected interest in methods to combat it. This article reviews the current status of vaccine development efforts against tularemia. To date most of our understanding of tularemia vaccine efficacy has been derived from the clinical and experimental use of a pragmatically attenuated live vaccine strain of F. tularensis subspecies holarctica. However, this vaccine which has been in existence for more than 50 years is still beset by regulatory issues that continue to hamper its licensure. These issues and possible solutions are highlighted, along with more modern molecular approaches to vaccine development against this highly virulent pathogen.