Miracle-dz/UniFAR-FTUs huggingface dataset:
210Pb and 210Po activities in French foodstuffs

The data on 210 Pb and 210 Po activities in French foodstuffs acquired during the last 15 years are numerous enough to derive reference values which will be usable to assess the dose to the French population due to the intake of these two natural radionuclides. The means and ranges are close to those observed in various countries and are most often higher than the reference values proposed by UNSCEAR. Mussels and oysters exhibit the highest 210 Po activities of all kinds of foodstuffs, with a mean value of 27 Bq.kg -1 fresh weight , followed by crustaceans and small fish species (anchovies, mullets, sardines, etc.) with 210 Po activities in the order of 3 to 10 Bq.k -1 fresh weight; cephalopods and other fish species presenting activities around 1 to 3 Bq.kg -1 fresh, close to the UNSCEAR reference value. Below these highest 210 Po activities are those of 210 Po and 210 Pb in terrestrial kinds of foodstuffs, by decreasing order: meats (around 1 Bq.kg -1 fresh), cereals (0.4 Bq.kg -1 ), leafy vegetables (0.3 Bq.kg -1 ), other vegetables and fruits (0.1 Bq.kg -1 ), and milk (from 0.03 to 0.1 Bq.L -1 ).
New alternatives for erythropoietin therapy in chronic renal failure

Erythropoietin (EPO) is one of the main cytokines involved in the regulation of erythropoiesis. The main site of EPO production are the kidneys. An altered EPO production leads to pathological conditions such as anemia and polycythaemia. Due to the progressive loss of renal peritubular cells, patients with chronic kidney disease (CKD) have low EPO plasma levels. This decreases erythron stimulation with the direct consequence of developing anemia. Before the introduction in the clinical practice of rHuEpo, in the late 1980s, the only solution for treating this type of anemia were blood transfusions and anabolic steroids. Even rHuEpo has proven to be safe and effective for treatment of anemias, there are some concerns about its cost, the need for frequent parenteral administration, and development of anti-EPO antibodies. These inconveniences prompted the search for novel erythropoiesis stimulating agents. Different strategies lead to isolation or chemical synthesis of such agents as darbepoetin alfa and EPO mimetics. In this review, we present some general aspects of EPO biology, with emphasis on chronic renal failure, and expose some of the alternatives to EPO used for anemia correction.
A review of the imaging and clinical management of solitary pulmonary nodules

•. A solitary pulmonary nodule is a common occurrence and there may be an overlap between benign and malignant features. •. CT assessment of morphology, density, size, growth rate and enhancement is useful. •. Positron emission tomography imaging is highly sensitive for lesions greater than 7 mm. •. New advances in dynamic MRI, computer aided detection and four-dimensional CT appear promising. The management of solitary pulmonary nodules (SPNs) often causes a clinical dilemma; the clinical challenge is to determine whether lesions are more likely to be benign or malignant. This article examines the imaging characteristics which can help to determine the probability of malignancy or benignity in an SPN, e.g. nodule contour, location, density, cavitation, attenuation, size, enhancement on CT, enhancement on MRI and metabolic characteristics on positron emission tomography. Computerised assessment of nodules is also examined in this article, including both the detection and analysis of morphology.
New improvements of the extended minimum cost flow phase unwrapping for processing multitemporal full resolution interferograms

We present an efficient space-time phase unwrapping (PhU) algorithm allowing us to analyze sequences of multitemporal full resolution differential Synthetic Aperture Radar (SAR) interferograms for the generation of deformation time-series. The core of the proposed technique is represented by the extended minimum cost flow (EMCF) PhU algorithm. Our method is based on a joint analysis of the spatial and temporal relationships among a set of properly selected multitemporal differential interferograms. More specifically, the key idea is to split the complex MCF network problem into that of simpler sub-networks. Accordingly, we start by identifying and solving a primary network that involves a proper selection of coherent pixels of the computed interferograms, representing the backbone structure of the overall network. Subsequently, this result is applied for constraining the solution of the sub-networks connected to the primary one, involving the entire set of analyzed pixels. This task is achieved by solving a constrained optimization problem based on the computation of a Constrained Delaunay Triangulation in the Azimuth/Range domain. The experimental results, achieved by applying the proposed approach to a dataset consisting of European Remote Sensing (ERS) SAR data acquired, from June 1992 to August 2007 over the Napoli (Italy) bay area, confirm the effectiveness of the proposed PhU approach.
The Synthesis of Trees in Chinese Landscape Painting Using Silhouette and Texture Strokes

d for more than three thousand years, Chinese painting emphasizes "implicit meaning", and painters’ using a minimal number of brush strokes to express their deepest feelings. Landscapes of the most important themes in Chinese painting. Trees are the essential painting objects. This resents a set of novel methods to automatically draw trees in Chinese ink painting from 3D al models. Outline rendering and texture generation uses the information of the silhouette, shade ntation of three-dimensional model’s surface to draw a particular tree. Four reference maps are ed to analyze the information for the bark texture. These methods can draw various styles of bark y defining the texture patterns. Finally, this paper demonstrates some results obtained with our ds: Non-Photorealistic Rendering (NPR), Chinese Landscape Painting, TS’UN, Texture Strokes, te, Curvature Map, Brush, and Texture Generation.
Gene expression, molecular docking, and molecular dynamics studies to identify potential antifungal compounds targeting virulence proteins/genes VelB and THR as possible drug targets against Curvularia lunata

Curvuluria lunata is a melanized fungus pathogenic to both plants and animals including humans, causing from mild, febrile to life-threatening illness if not well treated. In humans, it is an etiological agent of keratomycosis, sinusitis, and onychomycosis in immunocompromised and immunocompetent patients. The development of multiple-drug-resistant strains poses a critical treatment issue as well as public health problem. Natural products are attractive prototypes for drug discovery due to their broad-spectrum efficacy and lower side effects. The present study explores possible targets of natural antifungal compounds (α-pinene, eugenol, berberine, and curcumin) against C. lunata via gene expression analysis, molecular docking interaction, and molecular dynamics (MD) studies. Curcumin, berberine, eugenol, and α-pinene exhibited in vitro antifungal activity at 78 μg/ml, 156 μg/ml, 156 μg/ml, and 1250 μg/ml, respectively. In addition, treatment by these compounds led to the complete inhibition of conidial germination and hindered the adherence when observed on onion epidermis. Several pathogenic factors of fungi are crucial for their survival inside the host including those involved in melanin biosynthesis, hyphal growth, sporulation, and mitogen-activated protein kinase (MAPK) signalling. Relative gene expression of velB, brn1, clm1, and pks18 responsible for conidiation, melanin, and cell wall integrity was down-regulated significantly. Results of molecular docking possessed good binding affinity of compounds and have confirmed their potential targets as THR and VelB proteins. The docked structures, having good binding affinity among all, were further refined, and rescored from their docked poses through 100-ns long MD simulations. The MDS study revealed that curcumin formed a stable and energetically stabilized complex with the target protein. Therefore, the study concludes that the antifungal compounds possess significant efficacy to inhibit C. lunata growth targeting virulence proteins/genes involved in spore formation and melanin biosynthesis.
Bioinspired Surfaces with Superwettability: New Insight on Theory, Design, and Applications.

Design, and Applications Shutao Wang,†,‡ Kesong Liu, Xi Yao, and Lei Jiang*,†,‡,§ †Laboratory of Bio-inspired Smart Interface Science, Technical Institute of Physics and Chemistry, and ‡Beijing National Laboratory for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry and Environment, BeiHang University, Beijing 100191, People’s Republic of China Department of Biomedical Sciences, City University of Hong Kong, Hong Kong P6903, People’s Republic of China
Analysis of conversational discourse in head-injured adults

In the study discussed In this article, appropriateness In conversations with a research assistant was examined in closed head Injured (CHI) adults and compared with normal subjects. Utterances of a speakerinitiator were designated as obliges (those that clearly summon or demand a response) or comments (those that do not). A differential response to these initiatives described whether the speaker was appropriately extending the conversation. Utterances of a speaker-responder were evaluated on a scale of appropriateness (adequate plus, adequate, inadequate, ambiguous). Results indicated that the two subject groups could be distinguished on the basis of (1) the CHI subjects' greater number of turns per conversation, (2) the research assistant's higher percentage of obliges in conversations with the CHI subjects, and (3) the quality of speaker responses.
Should electronic cigarettes be as freely available as tobacco cigarettes? No

The Medicines and Healthcare Products Regulatory Agency has decided to license electronic cigarettes as medicines from 2016. Simon Chapman agrees with regulation, seeing e-cigarettes as another way for big tobacco to try to make nicotine addiction socially acceptable again, but Jean-François Etter (doi:10.1136/bmj.f3845) says restrictions will result in more harm to smokers
Trust the People! Populism and the Two Faces of Democracy

Populism, understood as an appeal to ‘the people’ against both the established structure of power and the dominant ideas and values, should not be dismissed as a pathological form of politics of no interest to the political theorist, for its democratic pretensions raise important issues. Adapting Michael Oakeshott's distinction between ‘the politics of faith’ and ‘the politics of scepticism’, the paper offers an analysis of democracy in terms of two opposing faces, one ‘pragmatic’ and the other ‘redemptive’, and argues that it is the inescapable tension between them that makes populism a perennial possibility.
Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients.

Thirteen patients with acute myeloid leukemia, 5 with active disease, 2 in molecular relapse, and 6 in morphologic complete remission (CR; median age, 62 years; range, 53-73 years) received highly purified CD56(+)CD3(-) natural killer (NK) cells from haploidentical killer immunoglobulin-like receptor-ligand mismatched donors after fludarabine/cyclophosphamide immunosuppressive chemotherapy, followed by IL-2. The median number of infused NK cells was 2.74 × 10(6)/Kg. T cells were < 10(5)/Kg. No NK cell-related toxicity, including GVHD, was observed. One of the 5 patients with active disease achieved transient CR, whereas 4 of 5 patients had no clinical benefit. Both patients in molecular relapse achieved CR that lasted for 9 and 4 months, respectively. Three of 6 patients in CR are disease free after 34, 32, and 18 months. After infusion, donor NK cells were found in the peripheral blood of all evaluable patients (peak value on day 10). They were also detected in BM in some cases. Donor-versus-recipient alloreactive NK cells were shown in vivo by the detection of donor-derived NK clones that killed recipient's targets. Adoptively transferred NK cells were alloreactive against recipient's cells, including leukemia. In conclusion, infusion of purified NK cells is feasible in elderly patients with high-risk acute myeloid leukemia. This trial was registered at www.clinicaltrial. gov as NCT00799799.
Foods may modify responsiveness to cancer immune checkpoint blockers by altering both the gut microbiota and activation of estrogen receptors in immune cells

Estrogen receptor alpha positive (ERα+) breast cancers are refractory to immune checkpoint blocker (ICB) monotherapy, while ICBs are part of a standard of care for triple negative breast cancers (TNBCs). Besides tumor ERα expression, another difference between the two types of breast cancers is that only ERα+ patients exhibit elevated tumor estradiol (E2) levels, compared with surrounding normal tissue. Recent evidence suggests that inhibition of ERα or activation of ERβ or G protein-coupled estrogen receptor (GPER) in immune cells in the tumor microenvironment (TME) increases tumor CD8+ T cell infiltration and boosts cancer ICB response. Ovarian and adipose-produced estrogens activate all three ERs equally, but plant estrogens (phytochemicals) preferentially activate ERβ or GPER. The gut microbiota is a key player in determining response to ICBs, and high abundance of Firmicutes and high fecal levels of short chain fatty acids (SCFAs) that are mainly produced by Firmicutes, are linked to improved effectiveness of ICB therapy. Interestingly, the gut microbiota of ERα+ breast cancer patients contain significantly lower abundance of Firmicutes species than the gut microbiota of TNBC patients. Many factors modify the gut microbiota, especially diet. The gut microbiota altering diets include (i) foods high in ERβ and GPER activating plant phytochemicals or (ii) SCFAs producing fiber that also reduces circulating estrogen levels, (iii) estrogen levels reducing fasting/caloric restriction, or (iv) ketogenic diet which reduces fecal SCFA levels but increases hepatic production of SCFA receptor activating ketone bodies. It is thus possible that certain foods or dietary patterns can modify both the gut microbiota and activation of the estrogen receptors in the tumor immune cells, and consequently regulate the effectiveness of ICB therapy against cancers.
Evolution of the donor T-cell repertoire in recipients in the second decade after allogeneic stem cell transplantation.

After allogeneic stem cell transplantation (SCT), T lymphocyte function is reestablished from the donor's postthymic T cells and through thymic T-cell neogenesis. The immune repertoire and its relation to that of the donor have not been characterized in detail in long-term adult SCT survivors. We studied 21 healthy patients in their second decade after a myeloablative SCT for hematologic malignancy (median follow-up, 12 years). Immune profiles were compared with donor samples cryopreserved at transplant and beyond 10 years from SCT. Only one recipient was on continuing immunosuppression. Compared with the donor at transplant, there was no significant difference in CD4, CD8, natural killer, and B-cell blood counts. However, compared with donors, recipients had significantly fewer naive T cells, lower T-cell receptor excision circle levels, fewer CD4 central memory cells, more effector CD8(+) cells, and more regulatory T cells. TCR repertoire analysis showed no significant difference in complexity of TCRVβ spectratype between recipients and donors, although spectratype profiles had diverged with both gain and loss of donor repertoire peaks in the recipient. In conclusion, long-term allogeneic SCT survivors have subtle defects in their immune profile consistent with defective thymic function but compatible with normal health. This study is registered at http://www.clinicaltrials. gov as NCT00106925.
Ionic liquids at electrified interfaces.

Until recently, “room-temperature” (<100–150 °C) liquid-state electrochemistry was mostly electrochemistry of diluted electrolytes(1)–(4) where dissolved salt ions were surrounded by a considerable amount of solvent molecules. Highly concentrated liquid electrolytes were mostly considered in the narrow (albeit important) niche of high-temperature electrochemistry of molten inorganic salts(5-9) and in the even narrower niche of “first-generation” room temperature ionic liquids, RTILs (such as chloro-aluminates and alkylammonium nitrates). (10-14) The situation has changed dramatically in the 2000s after the discovery of new moisture- and temperature-stable RTILs. (15, 16) These days, the “later generation” RTILs attracted wide attention within the electrochemical community. (17-31) Indeed, RTILs, as a class of compounds, possess a unique combination of properties (high charge density, electrochemical stability, low/negligible volatility, tunable polarity, etc.) that make them very attractive substances from fundamental and application points of view. (32-38) Most importantly, they can mix with each other in “cocktails” of one’s choice to acquire the desired properties (e.g., wider temperature range of the liquid phase(39, 40)) and can serve as almost “universal” solvents. (37, 41, 42) It is worth noting here one of the advantages of RTILs as compared to their high-temperature molten salt (HTMS)(43) “sister-systems”. (44) In RTILs the dissolved molecules are not imbedded in a harsh high temperature environment which could be destructive for many classes of fragile (organic) molecules.
Research on tipping calibration and exponent calibration based on LN2 for ground-based multi-channel microwave radiometer

Respect to ground-based microwave radiometer, the paper presents exponent calibration based on blackbody cooled by liquid nitrogen. In order to correct the calibration coefficients, this paper also presents tipping method at low optical depth (K band), which is different from common tipping method. It observes the clear-sky and clear-sky with noise injection to correct nonlinear factor and stability of noise. The calibration results show that using tipping method can achieve high resolution.
The Glasgow Coma Scale: History and current practice

The Glasgow Coma Scale (GCS) was devised to assess injury severity in a multi-centre study of outcome after severe brain damage. It uses unambiguous terms that are readily understood by a wide range of observers. Giving numbers to responses makes communication and display of responsiveness easy and the overall score allows classifi cation of overall severity of brain injury for triage and for epidemiological studies. The total score involves some loss of predictive information. Outcome correlates well with the early GCS both in head injuries and other intensive care patients. When early sedation and ventilation after head injury makes GCS assessment difficult, the motor score is often available and is a useful index of injury severity. The GCS also facilitates monitoring in the early stages after injury, allowing rapid detection of complications. Even among mild injuries (GCS 13- 15) the scale can discriminate between those more or less likely to have detectable brain damage and to be at risk of complications.
Quantitative Phase Imaging of Cells and Tissues

That's it, a book to wait for in this month. Even you have wanted for long time for releasing this book quantitative phase imaging of cells and tissues; you may not be able to get in some stress. Should you go around and seek fro the book until you really get it? Are you sure? Are you that free? This condition will force you to always end up to get a book. But now, we are coming to give you excellent solution.
Management of autism in children and young people: summary of NICE and SCIE guidance

Autism occurs in approximately 1% of children and young people,1 though the diagnosis is made less commonly in girls2 and anyone with severe intellectual disability.1 It is one of the most important causes of lifelong disability, with support and lost productivity costs estimated at more than £28bn (€32bn, $43bn) annually in the UK.3 Individual presentations vary widely, as do associated functional impairments, but the core features of autism are persistent impairment in reciprocal social interaction and social communication and restricted, repetitive patterns of behaviour, interests, or activities. These features occur whether or not the individual has an intellectual disability and are typically present in early childhood, though they may be masked by parental support or compensations. Intellectual disability, language impairment, academic deficits, and movement disorders are common,4 and mental and behavioural disorders are found in up to 70%. 5 The presence of all these factors, as well as sensory sensitivities, constipation, sleep and eating problems, and behaviour that challenges, add considerably to the impact on the child or young person, their family, and professionals in health and social care and education. This article summarises the most recent joint recommendations from the National Institute for Health and Care Excellence (NICE) and the Social Care Institute for Excellence (SCIE) on managing autism in children and young people.6 NICE recommendations are based on systematic reviews of the best available evidence and explicit consideration of cost effectiveness. When minimal evidence is available, recommendations are based on the Guideline Development Group’s experience and opinion of what constitutes good practice. Evidence levels for the recommendations are given in italic in square brackets. ### Access to health and social care services
Detection of ground moving targets in COSMO-SkyMed SAR images

The aim of this work is the development of processing techniques in order to provide the Cosmo-SkyMed (CSK) single-channel SAR system of Ground Moving Target Indication (GMTI) capabilities. To this purpose a two step processing chain is proposed: the first step performs stationary clutter suppression while the second step performs moving targets detection. For the last step two different detection schemes are proposed based respectively on a Bank of Chirp Scaling Algorithms (BCSA-MTD) and on a Change Detection approach (CD-MTD). The effectiveness of the proposed techniques is demonstrated against CSK data.
Pathophysiologie von koronarer Herzkrankheit und Herzinsuffizienz

Comorbid cardiovascular diseases can significantly increase the risk for perioperative morbidity and mortality. Increasing age of surgical populations and increasing invasiveness of surgical procedures further contribute to a significantly increased perioperative cardiovascular complication rate. Treatment of cardiovascular comorbidities and prevention of cardiovascular complications can decrease the perioperative risk. For detection and treatment of cardiovascular risk patients a thorough understanding of the underlying pathophysiology is of utmost importance. This article therefore reviews clinically relevant features of cardiovascular diseases with an emphasis on coronary artery disease and heart failure.