Miracle-dz/UniFAR-FTUs huggingface dataset:
PROTEIN KINASE C IN T CELL ACTIVATION

The novel protein kinase C (PKC) isoform, PKC theta, is selectively expressed in T lymphocytes and is a sine qua non for T cell antigen receptor (TCR)-triggered activation of mature T cells. Productive engagement of T cells by antigen-presenting cells (APCs) results in recruitment of PKC theta to the T cell-APC contact area--the immunological synapse--where it interacts with several signaling molecules to induce activation signals essential for productive T cell activation and IL-2 production. The transcription factors NF-kappa B and AP-1 are the primary physiological targets of PKC theta, and efficient activation of these transcription factors by PKC theta requires integration of TCR and CD28 costimulatory signals. PKC theta cooperates with the protein Ser/Thr phosphatase, calcineurin, in transducing signals leading to activation of JNK, NFAT, and the IL-2 gene. PKC theta also promotes T cell cycle progression and regulates programmed T cell death. The exact mode of regulation and immediate downstream substrates of PKC theta are still largely unknown. Identification of these molecules and determination of their mode of operation with respect to the function of PKC theta will provide essential information on the mechanism of T cell activation. The selective expression of PKC theta in T cells and its essential role in mature T cell activation establish it as an attractive drug target for immunosuppression in transplantation and autoimmune diseases.
Le globule gras du lait : sécrétion, composition, fonctions et facteurs de variation

Les proprietes nutritionnelles et technologiques de la matiere grasse laitiere dependent de sa composition et de la taille des globules gras qui la composent. Ces composantes sont maitrisables des l'elevage, les principaux leviers d'action etant lies a l'animal lui-meme ou a son alimentation. Cette revue bibliographique a pour objectif de decrire les mecanismes biochimiques et physiologiques a l'origine de la synthese et de la secretion de la matiere grasse laitiere, ainsi que les facteurs d'elevage permettant de les moduler et donc de modifier la composition et la taille des globules gras. Apres avoir resume les principales voies de synthese de la matiere grasse laitiere, les mecanismes supposes de sa secretion par le lactocyte sont explicites et les caracteristiques des globules gras (diametre, structure et composition de la membrane et du centre des globules gras) sont definies. Ensuite, leurs fonctionnalites technologiques, sensorielles et nutritionnelles sont presentees. Enfin, les facteurs d'elevage permettant de moduler ces caracteristiques sont detailles. Les globules gras sont probablement secretes par un melange d'exocytose et de secretion apocrine. Cette revue met en evidence le manque de connaissances actuelles concernant la co-regulation de la synthese et de la secretion de la matiere grasse laitiere et des autres constituants du lait. Les proprietes technologiques des globules gras sont sous la dependance de leur taille et leurs proprietes nutritionnelles sont liees en grande partie a la composition de leur membrane. La taille des globules gras, comme leur composition, est peu influencee par la race, le stade et le rang de lactation. Par contre, elle est sujette a de fortes variations individuelles, repetables et donc probablement heritables, laissant supposer une selection genetique efficace a long terme. La taille des globules gras est egalement influencee par l'alimentation, a savoir la nature, la forme d'apport et la quantite de fourrage.
Building Employee Performance: Analysis Discipline and Commitment (A Case Study at UPI Convention Center Padang)

This study aims to determine the effect of labor discipline and commitment to employee performance UPI convention center of Padang. This research was conducted in the environment UPI Padang convention center. The population in this study were all employees of the environment UPI Padang convention center. Samples were 30 people with porposional techniques. The type and source of research data consist of primary data is data obtained from the opinions of the respondents through the questionnaire research and secondary data is data obtained from UPI convention center Padang Data analysis techniques used in the research hypothesis testing is a multiple linear regression analysis using SPSS version 25.0.
The Chromatic Lagrangian: Wavefunctions and Open Gromov-Witten Conjectures

Inside a symplectic leaf of the cluster Poisson variety of Borel-decorated $PGL_2$ local systems on a punctured surface is an isotropic subvariety we will call the chromatic Lagrangian. Local charts for the quantized cluster variety are quantum tori defined by cubic planar graphs, and can be put in standard form after some additional markings giving the notion of a framed seed. The mutation structure is encoded as a groupoid. The local description of the chromatic Lagrangian defines a wavefunction which, we conjecture, encodes open Gromov-Witten invariants of a Lagrangian threefold in threespace defined by the cubic graph and the other data of the framed seed. We also find a relationship we call framing duality: for a family of"canoe"graphs, wavefunctions for different framings encode DT invariants of symmetric quivers.
Diamond Export and Economic Growth in Angola

This study is an attempt to examine the relationship between diamond export and economic growth in Angola during the period of 2001-2018. Based on the estimation of the autoregressive model of distributed lags, the study concludes that diamond exports and economic growth are cointegrated. In addition, there is a positive one-way causality in diamond exports for long-term economic growth, which supports energy infrastructure investment policies. On the other hand, the absence of some reverse causality of economic growth for diamond production and exports, highlights due to Angola's heavy reliance on foreign demand for its oil to drive economic growth. Thus, in turn, policymakers must also consider diversifying the economy into other growing sectors in order to mitigate the impact of global economic shocks. The diamond is the second most important resource in Angola, so the government has been using it as a means of diversifying the economy in order to balance the less good economic situation that the country lives.
Deciphering the biosynthetic pathway of carbon monoxide dehydrogenase, a key enzyme of the watergas shift reaction

CO dehydrogenase (CODH) is a key enzyme of the water gas shift reaction (WGSR) in hydrogenogenic carboxydotrophs such as Rhodospirillum rubrum, able to use CO as carbon and energy source. A remarkable feature of CODH is the presence of a unique active site, the C-cluster composed of a [NiFe4S4] center, of which very little is known about its biogenesis. Nickel insertion is essential for the enzyme activation and it requires the intervention of the accessory proteins CooC, CooJ and CooT, able to supply the nickel into the CODH. Here, I report the results obtained from the characterization of CooT and CooJ. From the CooT family, two CooT were studies: RrCooT and ChCooT. Concerning RrCooT, the peculiarity of its nickel-binding site was unveiled. Ni(II) is coordinated by bis-amidate/bis-thiolate ligands provided by both solvent-exposed Cys2, unprecedented in biology. The X-ray structure of ChCooT, as well as its biophysical characterization, revealed the identification of a “Cys2-His55” nickel-binding motif, highlighting the existence of two distinct Ni-binding modes in the same protein family. RrCooJ is a histidine-rich protein: the structural characterization of a truncated version lacking the His-tail enabled us to identify the presence of two nickel binding sites: a “high-affinity site” in the N-terminal part and a second one in the histidine-rich region, suggesting a double function for this protein in both nickel storage and CODH maturation. Further, RrCooJ undergoes a dynamical and reversible oligomerization process upon nickel exposure. Overall, these results bring the scientific knowledge a step forward towards the understanding of the CODH maturation pathway.
Internal Control Analysis towards the Accounts Receivable Accounting System at STIAMI Institute

This research aims to reveal how internal control of the accounts receivable system, obstacles faced on the internal control applied, and the endeavors made to reduce it at STIAMI Institute. This research use descriptive-analytical methods to determine the implementation of internal control and account receivable system. Based on the result of the research, internal control towards the account receivable accounting system implemented on STIAMI is quite efficient, indicated by the independence of the audit committee or the internal supervisory unit (ISU) in which are right under the head of STIAMI auspices. In addition, STIAMI's management has applied basic concepts and principles of internal control. In STIAMI internal control activities, it is better to enforce the functions and centralization of the online system so that the operations and financial statement presentation can run effectively and efficiently.
Autoimmune Polyglandular Syndrome Type 2 (APS-2) in a 70-Year-Old Woman: A Case Report

10.30699/jambs.27. 124.41 Type 2 autoimmune polyglandular (Schmidt) syndrome (APS-2) is defined by the occurrence of at least 2 out of 3 of the following manifestations, Addison's disease, Hypothyroidism and Type 1 diabetes mellitus. APS-2 is a rare condition with an incidence of 1–2/100 000 per year. Prevalence of APS-2 is most happening in the range of 20-40 years of age. Here we present a patient who complained about loss of appetite with significant weight loss also having trouble with her skin saying she had experienced progressively darkening of the skin all over her body and manifestations of Addison's disease at the age of 70. The patient was treated with oral Prednisolone, Fludrocortisone and Levothyroxine and evaluated after one month which showed the hormonal panel within the normal range.
Perancangan Tata Letak Fasilitas Produksi UKM Eko Bubut Menggunakan Metode Automated Layout Design Program (ALDEP)

Perancangan tata letak fasilitas produksi merupakan faktor yang mempengaruhi kinerja dari suatu perusahaan. UKM Eko Bubut merupakan sebuah UKM yang memproduksi kerajinan kayu seperti piring kayu. UKM telah beroperasi sejak tahun 2012 hingga saat ini dengan jumlah permintaan yang banyak, namun jumlah pesanan belum dapat dipenuhi. UKM menambahkan departemen kerja dalam kegiatan produksi untuk dapat memenuhi permintaan. Penambahan departemen kerja UKM harus lebih memperhatikan tata letak fasilitas yang baik, karena tata letak fasilitas UKM saat ini terdapat kegiatan back tracking yang jauh dari departemen kerja pengovenan ke departemen kerja pengecatan. UKM saat ini memiliki 12 departemen kerja. Tujuan dari penelitian adalah merancang ulang tata letak untuk menghindari kegiatan back tracking yang tinggi. Metode yang digunakan adalah metode ALDEP. Metode ALDEP merupakan metode yang menghasilkan lebih dari satu layout yang mempertimbangkan tingkat hubungan antar departemen. Setelah dilakukan perancangan tata letak dengan ALDEP, maka didapatkan 7 alternatif layout dengan jarak perpindahan material dan OMH yang berbeda. Layout alternatif yang dipilih berdasarkan score terbesar yaitu layout alternatif 6 yaitu 513 dengan jarak perpindahan material 104,43 meter dan OMH Rp. 7.632,82.
Biodiversity co‐benefits of reducing emissions from deforestation under alternative reference levels and levels of finance

The extent to which an international mechanism to reduce emissions from deforestation and degradation (REDD+) can also provide biodiversity co‐benefits will depend on whether the mechanism results in the retention of forest in countries harboring substantial biodiversity. Countries’ decisions whether or not to participate in REDD+ will be influenced by their national reference level of emissions from deforestation, below which their verified emissions can be credited as reductions. In this article, we explore the reduction in extinctions of forest species achieved under four alternative national reference level designs and three alternative levels of finance for REDD+. We use an 85‐country partial equilibrium model and species‐area relationships to estimate extinction rates for 2,472 nationally endemic forest‐dependent amphibian, bird and mammal species if a REDD+ mechanism had been in place during 2005–2010. Our results indicate that elements of REDD+ that are most effective for climate change mitigation—greater finance combined with reference levels which reduce leakage by promoting broad participation across countries with both high and low historical deforestation rates—also offer the greatest benefits for biodiversity conservation.
Etude de la voie de biosynthèse des phlorotannins chez les algues brunes, de la caractérisation biochimique d'enzymes recombinantes à l'étude des réponses écophysiologiques

Les phlorotannins, polymeres du phloroglucinol, sont des composes phenoliques (CP) uniquement retrouves chez les algues brunes (Pheophycees). Ces metabolites presentant des activites anti-oxydantes, interviendraient dans la formation de la paroi, mais a ce jour leur voie de biosynthese reste non elucidee. L'annotation du genome de l'algue brune Ectocarpus, a permis d'identifier des genes homologues codant pour des enzymes de la biosynthese des CP chez les plantes terrestres. Une polyketide synthase de type III (PKSIII), a ete caracterisee: elle synthetise le phloroglucinol. La recherche d'autres cibles a ete poursuivie sur des genes codant pour des chalcone-isomerases-like (CHIL), ainsi que pour des phenol-sulfotransferases homologues d'enzymes de sulfatation des flavonoides. Les CHIL se sont revelees etre des fatty acid binding protein (FAP) impliquees dans le metabolisme des acides gras. L'interet pour cette nouvelle famille a justifie leur caracterisation biochimique puis fonctionnelle par complementation de mutants FAP d'Arabidopsis thaliana. L'elucidation progressive des voies de biosynthese des phlorotannins a servi de base pour etudier les mecanismes de regulation de ce metabolisme chez les Phaeophycees. En combinant des approches integrees d'expression de genes cibles, de dosages et de profilages de phlorotannins solubles, nous avons pu montrer que ces composes assurent une protection constitutive chez Fucus vesiculosus en reponse aux UV-B, et que leur metabolisme serait induit tres precocement au cours de l'herbivorie. Le developpement d'outils moleculaires specifiques de ces voies metaboliques, ouvre de nouvelles perspectives en ecophysiologie et en ecologie.
Energy turnover and aerobic fitness in endurance athletes and in the general population

The impact of energy turnover on mechanisms relating to energy balance and energy metabolism in humans is still not fully understood. The objective of the present thesis is to partially clarify these mechanisms by identifying specific problems going along in individuals with high (e.g. endurance athletes) and low energy turnovers. In a first step, a systematic review assessing the energy expenditure, energy intake, and body composition in endurance athletes across the training season was conducted. We found that men and women endurance athletes showed important fluctuations in energy turnover across the training season. Secondly, the extent to which the physical activity levels (PAL) are associated with compliance to dietary micronutrient intake recommendations was explored. Results of the present thesis indicate that individuals with low energy turnover have a higher risk for the development of insufficient micronutrient intake, as those with higher PAL. We further showed by using a linear model that an increase in PAL up to levels of 2.0 and a concomitant linear increase in energy intake in order to cover for increased energy demands would reduce the prevalence of micronutrient deficiencies. Finally, our work demonstrated that for the valid assessment of maximum metabolic equivalent of task and energy expenditure the resting oxygen consumption should be measured or, if not possible, estimated by use of published validated equations. To conclude, the energy and nutrient requirements of individuals with high energy turnover (viz. endurance athletes) are not static over the training year and strongly dependent on daily PAL. In addition, promotion of physical activity is important not only for weight management but also for adequate energy and micronutrient intake. In general, caution must be taken when interpreting energy expenditure data, where the calculation is based on an estimated or a standard resting oxygen consumption value.
Understanding the mechanisms behind onion bulb dormancy in relation to the potential for improved onion storage

i ACKNOWLEDGEMENTS . iii LIST OF CONTENTS . iv LIST OF FIGURES . x LIST OF TABLES . xviii NOTATION . xx 1.0 CHAPTER ONE: INTRODUCTION . 1 1.1 Project background . 1 1.2 Aim and objectives . 1 1.2.1 Aim . 1 1.2.2 Objectives . 2 1.3 Thesis structure . 2 2.0 CHAPTER TWO: LITERATURE REVIEW . 6 2.1 Allium cepa L. 6 2.2 Economic importance of the onion crop in the UK . 6 2.3 The onion lifecycle . 8 2.3. 1 Bulb initiation and formation . 9 2.3. 2 Onion bulb dormancy . 10 2.4 Quality attributes of marketable onions . 11 2.5 Strategies to delay sprouting . 12 2.6 Pre-harvest factors that affect storage life . 12 2.6. 1 Pre-harvest nutrition . 12 2.6. 2 Growing season temperature . 13 2.6. 3 Maleic hydrazide . 14 2.6. 4 Crop maturity at harvest . 15 2.6. 5 Harvesting process . 15
Saliva - An Efficient Tool in the Estimation of Glucose Level - A Comparative Study

Diabetes mellitus necessitate a repeated observation of serum glucose levels in the body. The commonly used diagnostic fluid for finding the glucose levels in the blood, but it is an invasive and unpleasant custom. Methods: Twenty diabetic and non-diabetic subjects were randomly selected. The perceptible assessment of blood and salivary glucose levels were performed by the glucose oxidase enzyme method using glucose oxidase-peroxidase kit. Results: A correlation was observed between HbA1c and salivary glucose of diabetic as well as non-diabetic subjects. The result showed a highly convinced positive correlation between salivary glucose and serum glucose in both diabetic patients and controls. Conclusion: From this study, it was achieved that salivary glucose level was a nearly new noninvasive indicative technique, and used as a survey tool to estimate the glycemic state of Type II diabetes mellitus patients.
Activation of Transcription by Estrogen Receptor α and β Is Cell Type- and Promoter-dependent*

Tamoxifen acts as a strong estrogen antagonist in human breast but as an estrogen agonist in the uterus. The action of tamoxifen is mediated through estrogen receptors (ERα and ERβ), which bind to a variety of responsive elements, to activate transcription. To examine the role of these varied elements in the response to antiestrogens, we studied the activation of a panel of differing promoters, by these compounds, in human breast, bone, and endometrial derived cell lines. No agonistic activity was observed in breast cells, whereas all antiestrogens, particularly tamoxifen, exhibited agonistic effects in uterine cell lines. All antiestrogens studied were agonistic in co-transfections of a collagenase reporter gene and ERβ, but tamoxifen alone was agonistic with ERα in (uterine) HEC-1-A cells. The ERα mediated, agonism of tamoxifen was not observed in primary cultures of human uterine stromal cells, whereas the ERβ-mediated agonism of all selective estrogen receptor modulators was present. This suggests that the two receptors operate by distinct pathways and that the response of cells to antiestrogens is dependent on the ER subtypes expressed.
ENZYMATIC BASIS FOR ASSIMILATORY AND DISSIMILATORY SULFATE REDUCTION

Peck, H. D. , Jr. (Oak Ridge National Laboratory, Oak Ridge, Tenn.). Enzymatic basis for assimilatory and dissimilatory sulfate reduction. J. Bacteriol. 82: 933–939. 1961. —Two pathways for the reduction of sulfate to sulfite in bacteria have been previously described. The substrate for sulfate reduction by extracts of yeast is 3′-phosphoadenosine-5′-phosphosulfate (PAPS) and, in contrast, the substrate for sulfate reduction in extracts of Desulfovibrio desulfuricans is adenosine-5′-phosphosulfate (APS). The enzymes catalyzing these reductions have been termed PAPS-reductase and APS-reductase, respectively. Since yeasts are “assimilatory sulfate reducers”, i.e., reduce only enough sulfate to satisfy nutritional requirements for sulfur, and D. desulfuricans is a “dissimilatory sulfate reducer”, i.e., utilizes sulfate as its terminal electron acceptor in anaerobic respiration, the pathway of sulfate reduction was determined in 25 microorganisms to ascertain whether there is a correlation between the pathway of sulfate reduction and the physiological role of sulfate in the metabolism of bacteria. Assimilatory sulfate reducers reduced sulfate in the form of PAPS, and, with one exception, APS-reductase was found only in dissimilatory sulfate reducers. APS-reductase was also found in the Thiobacilli in high specific activity and is involved in the oxidation of reduced sulfur compounds to sulfate.
From Learning Ecologies to Ecologies for Creative Practice

To perform any role requiring complex thinking and action involves being able to assess a situation, decide what action needs to be taken, and then pursue it using appropriate behaviours, tools, and methodologies; monitoring the effects and results of one’s actions; and responding to the feedback received (Eraut and Hirsh, 2007, p. 18). This process is at the core of what I am calling an ecology of practice that enables a person to create and achieve something of value within particular fields of knowledge and skill, contexts, situations, and circumstances. The core proposition underlying this chapter is that performing a complex role involves the creation of an ecology of practice that enables people to engage and interact with their environment and the things in it that matter to them and to solve domain-specific problems and communicate their learning through making and sharing new disciplinary artefacts. Their ecology of practice connects and immerses them—as whole sensing, thinking, and dynamic organisms—with their environment, and through skilled interactions, they take in the reaction of the environment and they are then changed (Dewey, 1916). I am using Ingold’s concept of environment, namely ‘the world as it exists and takes on meaning in relation to [the person], and in that sense it came into existence and undergoes development with [the person]’ (Ingold, 2000, p. 20). A second and related proposition is that creativity emerges while an ecology of practice is being enacted, through the ongoing purposeful interactions of a unique person with his or her unique environment as he or she strives to create value. When viewed from this perspective, our ecologies for achieving something of value constitute one of our most significant and fundamental acts of creativity. 12