Miracle-dz/UniFAR-FTUs huggingface dataset:
IMMUNOLOGICAL STUDIES OF TOXOPLASMOSIS IN THE SHEEP MODEL IN BAGHDAD /IRAQ

A total of 102 Iraqi breeds mature ewes and rams (6 rams and 96 ewes') examined whether Toxoplasma gondiassociated abortion occur in successive lambing, submitted from different points of north and central Baghdad/Iraq, were analyzed to determine the role of T.gondiiin abortion and to study advanced techniques in diagnosis of the Toxoplasmosis i nfection (serologyserum electrophoresis -latex agglutination -Eliza and phagocytic activity). We identified 96 ewes that gave birth to lambs on at least 1 successive year over and 6 males our study period, 2010 �2011.Blood samples from these animals wereanalyzed by latex agglutination to determine infection status with T.gondi. PhagocyticactivitiesbyELIZA assayandserumelectrophoresisduring study period, 2010 �2011.Results revealed that animals were highly infected with toxoplasmosis the infectivit y percentage was 38% for total animals (4% males and 34% while the infectivity percentage for ewes with toxoplasmosis was 41% ( 11.59 rams and 29.41 % ewes) highly titer of toxoplasmosis antibodies at the level of 512 were recorded 20% of ewes. While the bru cella antibodies titers in other ewes were at the level of 128. Present study results reported highly infectivity percentage with toxoplasmosis in sloutring rams and ewes submitted from different points of north and central Baghdad/Iraq.
[Pulmonary tuberculosis (in adults)].

The World Health Organization (WHO) defines pulmonary tuber culosis (TB) as tuberculous disease that involves the lung paren chyma. Tuberculosis involving the trachea is often also included in the definition. Extrapulmonary TB is disease involving any part of the body other than lung parenchyma including other structures within the thorax such as the pleura, pericardium and perihilar lymph nodes. This distinction is most important from a public health per spective because patients with untreated pulmonary TB pose an infectious risk to the rest of the community, whereas the risk to the community from extrapulmonary TB is minimal. Thus patients with pulmonary TB who also have extrapulmonary involvement are clas sified as cases of pulmonary TB by the WHO. In addition to classification by location, TB has traditionally been classified as primary or postprimary disease. Primary infection includes the symptoms and complications arising from the first con tact between host and the bacillus and is most clearly defined by conversion from a negative to a positive tuberculin skin test (TST). In the minority, the primary complex results in local progression or distant disease; in the majority, the complex resolves. Postprimary TB disease usually follows the primary infection by years, occurring through reactivation or reinfection. Other nearly synonymous terms with postprimary TB include reactivation TB, recrudescent TB, endogenous reinfection and adult type progressive TB. In years past, primary TB was considered a disease of children and post primary TB a disease of adults. In the era of human immunodefi ciency virus (HIV) distinctions between primary and postprimary TB have become increasingly blurred as primary TB is often seen in HIV infected adults. This chapter focuses on the clinical presentation of pulmonary TB and its complications. The classic presentation of primary and postprimary pulmonary TB among HIV uninfected adults and the atypical presentations of pulmonary TB associated with HIV and other immunosuppressive diseases and drugs are described along with the differential diagnoses. The impact of active TB case finding on clinical presentation and its public health impor tance is also included.
Novel Causes of Generalized Glucocorticoid Resistance

Glucocorticoid resistance is a rare condition characterized by generalized, partial, target-tissue insensitivity to glucocorticoids. Compensatory elevations in circulating adrenocorticotropic hormone (ACTH) concentrations lead to increased secretion of cortisol and adrenal steroids with mineralocorticoid and/or androgenic activity, but no clinical evidence of hypercortisolism. The clinical spectrum of the condition is broad, ranging from asymptomatic to severe cases of hyperandrogenism, fatigue and/or mineralocorticoid excess. The molecular basis of glucocorticoid resistance has been ascribed to mutations in the human glucocorticoid receptor (hGR) gene, which impair glucocorticoid signal transduction, thereby altering tissue sensitivity to glucocorticoids. The study of functional defects of natural hGR mutants enhances our understanding of the molecular mechanisms of hGR action and highlights the importance of integrated cellular and molecular signaling mechanisms for maintaining homeostasis and preserving normal physiology.
ANÁLISE DA HEURÍSTICA DA ANCORAGEM NA PRECIFICAÇÃO DE AUTOMÓVEIS SEMINOVOS EM UBERLÂNDIA-MG

Das decisoes mais simples as mais complexas, o processo de tomada de decisao e uma constante na rotina diaria das pessoas e organizacoes. As Financas Comportamentais surgem para complementar as Financas Classicas, esclarecendo que o ser humano nao e tao racional como se imaginava ao decidir entre diversas alternativas. Neste cenario, as heuristicas vem para reduzir as exigencias do processamento de informacoes e para lidar com as limitadas habilidades cognitivas que as pessoas e empresas possuem na tomada de decisoes. A Heuristica da Ancoragem ocorre quando o individuo se utiliza de um valor de referencia (ou âncora) para definir quais acoes ira tomar frente a um problema ou oportunidade. Sob esta perspectiva, o objetivo deste trabalho foi avaliar a influencia da Heuristica da Ancoragem no processo de precificacao de veiculos seminovos de Uberlândia-MG. O estudo dos vieses cognitivos, em especial o estudo da Heuristica da Ancoragem, surge em um contexto de questionamento das Teorias Classicas de Financas, que pressupoem a racionalidade ilimitada do ser humano. O arcabouco teorico da pesquisa envolveu principalmente os estudos de Jacowitz e Kahneman (1995) e Oliveira, Peixoto e Fagundes (2015). Esta investigacao se classifica como descritiva e quantitativa e foi delineada como um quase-experimento, isto e, um metodo de pesquisa em que o pesquisador nao controla as variaveis de entrada do sistema e ha um tratamento nao randomico dos experimentos. Utilizaram-se questionarios com perguntas quantitativas e qualitativas que foram aplicados a 45 (quarenta e cinco) vendedores de automoveis usados de Uberlândia-MG no ano de 2015. Sabe-se que a frota de veiculos uberlandense (mais de 425.000 veiculos em 2015) corresponde a segunda maior frota do estado de Minas Gerais e a vigesima do Brasil, segundo dados do DENATRAN, o que justifica a escolha deste mercado para analise. Procedeu-se, entao, ao calculo de um Indice de Ancoragem e da segmentacao da amostra entre os seguintes grupos: grupo de calibragem e dois grupos experimentais (grupo de âncora alta e grupo de âncora baixa). Como principais resultados, observou-se que o indice de ancoragem quando avaliado para o grupo de âncora alta foi de 0,66, indicando que as avaliacoes dos vendedores moveram-se mais de 66% em direcao a âncora estabelecida. Por sua vez, para o grupo de âncora baixa, o indice de ancoragem foi igual a 0, significando inexistencia do vies neste sentido. No caso do grupo de âncora baixa, supoe-se que os vendedores tinham uma nocao precisa de que o preco de venda poderia ser mais alto, provavelmente em funcao de um certo “agio” decorrente da relacao oferta versus demanda. Em suma, constatou-se que a utilizacao de âncoras tem influencia no processo decisorio de precificacao de veiculos seminovos de Uberlândia para o periodo e amostra considerados.
Cloning and primary structure of the chiA gene from Aeromonas caviae

The chiA gene from Aeromonas caviae encodes an extracellular chitinase, 865 amino acids long, that shows a high degree of similarity to chitinase A of Serratia marcescens. Expression in Escherichia coli yielded an enzymatically active protein from which a leader sequence was removed, presumably during transport of the enzyme across the cell membrane.
Are Diet Quality Scores After Breast Cancer Diagnosis Associated with Improved Breast Cancer Survival?

Previous studies have found that diets rich in fruits and vegetables are associated with reduced breast cancer mortality. However, these eating patterns do not necessarily reflect overall diet quality. The association of breast cancer mortality with a priori defined dietary scores, which are based on recommended dietary guidelines and reflect diet quality, has not been evaluated. We hypothesized that diet quality indices based on recommended guidelines are associated with decreased risk of breast cancer and nonbreast cancer mortality in breast cancer survivors. We examined the association between the Dietary Approaches to Stop Hypertension (DASH) score, and the Alternative Healthy Eating Index (AHEI)-2010, and the risk of breast cancer mortality and total mortality among women from the Nurses’ Health Study diagnosed with breast cancer. Adherence to DASH-style and AHEI-2010 diets were associated with reduced risk of nonbreast cancer mortality (comparing the fifth quintile with the first quintile, relative risk (RR) = 0.72, 95% confidence interval (CI): 0.53–0.99, P trend = 0.03 for DASH, and RR = 0.57, 95% CI: 0.42–0.77, P trend <0.0001 for AHEI-2010). Diet scores were not significantly associated with breast cancer mortality. Our findings suggest that adherence to a higher quality diet after breast cancer diagnosis does not considerably change the risk of breast cancer death and recurrence. However, healthy dietary choices after breast cancer were associated with reduced risk of nonbreast cancer mortality in women with breast cancer.
Variability and repeatability of quantitative, Fourier-domain optical coherence tomography Doppler blood flow in young and elderly healthy subjects.

PURPOSE The purpose of this study was to determine the within-session variability and between-session repeatability of spectral Fourier-domain optical coherence tomography (Doppler FD-OCT) Doppler retinal blood flow measurements in young and elderly subjects. METHODS Doppler FD-OCT blood flow was measured using the RTVue system. One eye of each of 20 healthy young (24.7 ± 2.7 years) and 16 healthy elderly (64.6 ± 5.1 years) subjects was randomly selected, and the pupil was dilated. The double circular scanning pattern of the RTVue was employed. Six Doppler FD-OCT measurements (i.e., each separate measurement comprising an upper and a lower nasal pupil scan) were acquired at each session. Measurements were repeated approximately 2 weeks later. Total retinal blood flow was calculated by summing flow from all detectable venules surrounding the optic nerve head. The coefficient of variation (COV) and coefficient of repeatability (COR) were calculated for each individual. RESULTS The individual COVs for retinal blood flow for young subjects ranged from 0.4% to 20.4% (median 7.5%) and for the elderly subjects ranged from 0.6% to 34.6% (median 9.2%). The group mean CORs for retinal blood flow for young participants were 6.4 μL/min (median 5.91 μL/min, relative to a mean effect 39.8 μL/min) and for elderly subjects were 10.5 μL/min (median 9.2 μL/min, relative to a mean effect 46.4 μL/min). CONCLUSIONS Doppler FD-OCT gave consistent and repeatable blood flow measurements within retinal venules in normal subjects. Considering the individual variation in blood flow measurements, confidence limits for retinal hemodynamics need to be determined on an individual basis.
Single-section counting error when distinguishing between primordial and early primary follicles in sections of rat ovary of different thickness.

UNLABELLED The number of primordial follicles within an ovary is frequently determined by counting 5, 7 or 10 microns thick sections and multiplying by the fraction of sections counted and a correction factor to adjust for duplicate counts. The objectives of the present study were: (i) to evaluate the accuracy of the correction factor developed by Abercrombie (1946); (ii) to evaluate the accuracy of the classification of primordial follicles from single tissue sections; and (iii) to determine the incorporation rate of 5-bromo-2-deoxyuridine into primordial follicles. In Expt 1, rat ovaries were sectioned at a thickness of 5, 7 or 10 microns. Primordial follicles were counted and classified across ten adjacent ovarian sections. The percentage of primordial follicles from single sections that were counted twice was 10, 9 and 2% in 5, 7 and 10 microns sections, respectively. This was lower than predicted by Abercrombie's method. The major error in counting from single sections was classification of early primary follicles as primordial follicles (55, 33 and 3% in 5, 7 and 10 microns sections, respectively). In Expt 2, a mean of 12 +/- 7% of primordial follicles incorporated 5-bromo-2-deoxyuridine after infusion for 7 days (four of seven rats had no labelled primordial follicles). IN CONCLUSION (i) Abercrombie's correction factor should not be used for adjusting counts of follicles; (ii) evaluation of primordial follicles from single sections gives inaccurate counts and incorrect classification is of greater importance than duplicate counting, particularly in thinner sections; (iii) for evaluation of the number of follicles, 10 microns is the optimal thickness; and (iv) primordial follicles incorporated 5-bromo-2-deoxyuridine infrequently.
Attribution style and psychosis: evidence for an externalizing bias in patients but not in individuals at high risk

Background. The aims of the study were to investigate whether (i) patients with lifetime presence of non-affective psychosis show an external-personal attribution bias for negative events, (ii) this attribution style can also be detected in first-degree relatives of patients with psychosis and subjects with subclinical psychotic experiences, and (iii) this attribution style is related to the presence of psychotic symptoms, in particular delusions. Method. Participants were 23 patients with lifetime presence of non-affective psychosis, a high- risk group of 36 first-degree relatives of patients with non-affective psychosis, a high-risk group of 31 subjects with subclinical psychotic experiences and 46 normal controls. Attribution style was measured by the Internal, Personal and Situational Attribution Questionnaire. Positive symptoms were assessed with the Present State Examination (PSE) and the Scale for the Assessment of Positive Symptoms (SAPS). Results. Relative to the controls, an externalizing bias was apparent in the patient group (β=0·20, p=0·03) but not in the two high-risk groups. There was a dose–response association between externalizing bias and the delusions subscale of the PSE (relative to lowest level: highest level of delusions: β=0·53, p=0·04; intermediate levels of delusions: β=0·23, p=0·35). No significant differences were found in personalizing bias between the four groups. Conclusions. Patients with psychosis tend to use an externalizing bias in their explanations of negative social events, and this bias is associated with the presence of positive psychotic symptoms, in particular delusions. A deviant attribution style is not part of the vulnerability to psychosis.
Changes induced by physical activity and weight loss in the morphology of intermyofibrillar mitochondria in obese men and women.

CONTEXT In obesity, skeletal muscle insulin resistance may be associated with smaller mitochondria. OBJECTIVE Our objective was to examine the effect of a lifestyle-modification intervention on the content and morphology of skeletal muscle mitochondria and its relationship to insulin sensitivity in obese, insulin-resistant subjects. DESIGN In this prospective interventional study, intermyofibrillar mitochondrial content and size were quantified by transmission electron microscopy with quantitative morphometric analysis of biopsy samples from vastus lateralis muscle. Systemic insulin sensitivity was measured with euglycemic hyperinsulinemic clamps. SETTING The study took place at a university-based clinical research center. PARTICIPANTS Eleven sedentary, overweight/obese volunteers without diabetes participated in the study. INTERVENTION Intervention included 16 wk of aerobic training with dietary restriction of 500-1000 kcal/d. MAIN OUTCOME MEASURES We assessed changes in mitochondrial content and size and changes in insulin sensitivity. RESULTS The percentage of myofiber volume occupied by mitochondria significantly increased from 3.70 +/- 0.31 to 4.87 +/- 0.33% after intervention (P = 0.01). The mean individual increase was 42.5 +/- 18.1%. There was also a change in the mean cross-sectional mitochondrial area, increasing from a baseline of 0.078 +/- 0.007 to 0.091 +/- 0.007 microm(2) (P < 0.01), a mean increase of 19.2 +/- 6.1% per subject. These changes in mitochondrial size and content highly correlated with improvements in insulin resistance (r = 0.68 and 0.72, respectively; P = 0.01). CONCLUSIONS A combined intervention of weight loss and physical activity in previously sedentary obese adults is associated with enlargement of mitochondria and an increase in the mitochondrial content in skeletal muscle. These findings indicate that in obesity with insulin resistance, ultrastructural mitochondrial plasticity is substantially retained and, importantly, that changes in the morphology of mitochondria are associated with improvements in insulin resistance.
Mercury Exposure in Children With Autistic Spectrum Disorder: Case-Control Study

Although mercury has been proven to be a neurotoxicant, there is a lack of data to evaluate the causal relationship between mercury and autism. We aim to see if there is increased mercury exposure in children with autistic spectrum disorder. We performed a cross-sectional cohort study over a 5-month period in 2000 to compare the hair and blood mercury levels of children with autistic spectrum disorder (n = 82; mean age 7.2 years) and a control group of normal children (n = 55; mean age 7.8 years). There was no difference in the mean mercury levels. The mean blood mercury levels of the autistic and control groups were 19.53 and 17.68 nmol/L, respectively (P = .15), and the mean hair mercury levels of the autistic and control groups were 2.26 and 2.07 ppm, respectively (P = .79). Thus, the results from our cohort study with similar environmental mercury exposure indicate that there is no causal relationship between mercury as an environmental neurotoxin and autism. (J Child Neurol 2004;19:431-434).
Spam Detection Proposal in Regular and Text-based Image Emails

Spam, Emails are invading users without their consent and filling their mail boxes with Email trash. Priceless effort and time of the users and organizations are wasted in handling them. To circumvent anti-spam solutions, many spammers are sending spam Email with image-only content. In this paper we propose a spam detection approach in Emails with text and image contents. In the first part, a novel framework for extracting intelligent information from Emails with image content is presented and a prototype implementation is shown. In the second part, a proposal for multi-layered spam detection algorithm is presented, which enhances existing approaches
Caractérisation de l'hyperexcitabilité cérébrale dans des modèles murins d'épilepsies génétiques et développement d'une nouvelle stratégie pour la réduire

Mes travaux de these ont porte sur l’etude de deux modeles murins d’epilepsies genetiques de l’enfance liees a des mutations des canaux Nav1.1 (impliques dans l’excitabilite des neurones inhibiteurs) : le Syndrome de Dravet (SD), une epilepsie pharmaco-resistante severe, et l’Epilepsie Genetique avec Convulsions Febriles Plus (EGCF+), presentant un phenotype plus modere.Ils se sont decomposes en 3 axes : - La premiere partie mettant en evidence un phenomene d’epileptogenese dans ces modeles murins. - La seconde permettant d’identifier des conditions experimentales d’induction d'activites epileptiformes specifiques du modele murin du SD sur des tranches de cerveau. - La derniere consistant a mettre au point une strategie pour reduire l’hyperexcitabilite cerebrale
Advanced fuzzy control of a trailer type mobile robot-stability analysis and model-based fuzzy control

In a previous paper (see "A Robust Stabilization Problem of Fuzzy Controller Systems and Its Applications to Backing up Control of a Truck-Trailer", IEEE Trans. on Fuzzy Systems, Vo1.2, no.2, p.119-34, 1994), we designed a control system for backing up a computer simulated trailer type mobile robot, which is non-linear and unstable, by applying a robust stabilization technique for fuzzy systems. Furthermore, we have shown that the designed fuzzy controller smoothly achieves backing up control of the computer simulated trailer type mobile robot from all initial positions. We control a real trailer type mobile robot by applying the design method proposed previously. The experimental results show that the designed fuzzy controller effectively realize backing up control of the real trailer type mobile robot. <<ETX>>
Addition of the neurokinin 1 receptor antagonist aprepitant to standard antiemetic therapy improves control of chemotherapy‐induced nausea and vomiting

Aprepitant is a novel neurokinin 1 (NK1) antagonist that has been shown to improve control of chemotherapy‐induced nausea and vomiting (CINV) when added to a standard antiemetic regimen of a 5‐hydroxytriptamine‐3 antagonist plus a corticosteroid. The authors sought to evaluate further the efficacy and tolerability of aprepitant plus standard therapy in a large clinical trial.
Complement Activation in Very Early Alzheimer Disease

The activation of the classical complement (C)-system in early-stage Alzheimer disease (AD) and nondemented aging was examined with immunohistochemistry in subjects assessed by the Clinical Dementia Rating (CDR). Activation (staining for C3 and C4 fragments) was found in all brains with amyloid deposits, including all nondemented (CDR 0) cases, with either small numbers of diffuse plaques or with sufficient plaques and tangles to indicate preclinical AD. Staining for C3 and C4 increased in parallel with plaque density in very mild to severe clinical AD. A subset of very mild AD (CDR 0.5) cases also showed C1q (on plaques) and C5b-9 (on neuritic plaques and tangles), whereas these C-fragments were consistently found in severe AD (CDR 3). Mirror section (split-face) analysis showed that C1q, C3, and apoJ (clusterin) occurred on the same plaques. However, C-system regulators CD59, CR1, DAF, and MCP were not detected on plaques or tangles at any stage, indicating that C-activation related to AD is incompletely controlled.
Student Achievement in a Blended-Learning Environment : Lessons From the Cisco Networking Academy

This paper examines the student, program delivery and school factors that influenced student achievement in the Cisco Networking Academy. The Academy uses the Internet to distribute a centrally developed curriculum and standards-based online testing, and combines that with local instructors who teach classes to students. This study, conducted with 10,371 students at 1,651 schools, found that individual student ability, gender, age, and motivation were the most important influences on student achievement. Instruction quality was also important, but unlike prior studies, the impact of school level factors was small. We conclude that this combination of centralized curriculum, standards-based testing, and local instruction worked equally well in a variety of environments and enabled students to reach their own potential.