Miracle-dz/UniFAR-FTUs huggingface dataset:
Measuring individual corrective reaction time using the intermittent illumination model

The corrective reaction time (tcr) is an essential motor property when modelling hand control movements. Many studies designed experiments to estimate tcr, but reported only group means with inconsistent definitions. This study proposes an alternative methodology using Drury's (1994) intermittent illumination model. A total of 24 participants performed circular tracking movements under five levels of visual information delay using a modified monitor in a darkened room. Measured movement speeds and the manipulated delays were used with the model to estimate tcr of individuals and test effects of gender and path width. The results showed excellent model fits and demonstrated individual differences of tcr, which was 273 ms on average and ranged from 87 to 441 ms. The wide range of tcr values was due to significant effects of gender and path width. Male participants required shorter tcr compared to female participants, especially for narrow path widths. Practitioner Summary: This study reports the corrective reaction time (tcr) of individuals using a novel methodology. The estimated tcr ranged from 87 to 441 ms, helping model hand control movements, such as aiming and tracking. The methodology can be continuously applied to study tcr under conditions with various performers and movements.
Diagnosis of asthma – a new approach

Current definition of asthma involves four cornerstones: inflammation, hyperresponsiveness, bronchoconstriction, and symptoms. In research, the symptoms have had the slightest attention. According to international guidelines, the asthma symptoms are episodic breathlessness, wheeze, cough, tightness of the chest, and shortness of breath. As there are several symptoms, a primary question is how they are related to bronchoconstriction, the main clinical feature of asthma. Symptoms and lung function tests are regularly used for the evaluation of clinical health status and effect of treatment. However, there is no or poor correlation between these two variables, which means that they represent different mechanisms. Reduced lung function, such as a low FEV1, represents bronchial constriction, what do the symptoms represent? Some symptoms such as breathlessness and shortness of breath seem not to be evidence‐based asthma symptoms. Focusing on bronchial obstruction is important in view of the potential risk of asthma attacks, but nonobstructive symptoms occur frequently and may also cause severe discomfort and poor quality of life. Interpreting all symptoms as signs of bronchoconstriction (asthma) may lead to misinterpretation when assessing health status and effect of treatment. Although a ‘soft’ variable, the strength of symptoms is that they are representing various mechanisms. The physiological preconditions for control and defense of respiration must be considered in the diagnostic process, regardless of inflammation, allergy, psychology, or other etiological factors. Based on studies on dyspnea in cardiopulmonary diseases, including asthma and asthma‐like disorders, there seems to be a continuous spectrum of symptoms and mechanisms integrated in a single asthma syndrome.
Testing usability and trainability of indirect touch interaction: perspective for the next generation of air traffic control systems

This study aims to determine whether indirect touch device can be used to interact with graphical objects displayed on another screen in an air traffic control (ATC) context. The introduction of such a device likely requires an adaptation of the sensory-motor system. The operator has to simultaneously perform movements on the horizontal plane while assessing them on the vertical plane. Thirty-six right-handed participants performed movement training with either constant or variable practice and with or without visual feedback of the displacement of their actions. Participants then performed a test phase without visual feedback. Performance improved in both practice conditions, but accuracy was higher with visual feedback. During the test phase, movement time was longer for those who had practiced with feedback, suggesting an element of dependency. However, this ‘cost’ of feedback did not extend to movement accuracy. Finally, participants who had received variable training performed better in the test phase, but accuracy was still unsatisfactory. We conclude that continuous visual feedback on the stylus position is necessary if tablets are to be introduced in ATC. Practitioner Summary: We investigated the possibility of integrating a tablet computer as an input device in air traffic control. While we found that practice globally improved pointing performance, we concluded that the presence of continuous visual feedback on the stylus position is necessary to guarantee selection efficiency.
Psychophysiological responses in experienced firefighters undertaking repeated self-contained breathing apparatus tasks

In order to safely and effectively extinguish fires and rescue life, firefighters are required to routinely wear self-contained breathing apparatus (SCBA), yet little is known about the specific physiological and psychological demands associated with repeated exposure to tasks that require SCBA. A total of 12 experienced firefighters took part in a series of commonly encountered SCBA activities: free search, guideline search and live firefighting tasks under room temperature (∼20°C) and extreme heat (∼180°C) conditions to assess changes in heart rate, blood pressure, mood, perceived workload and air usage. Findings demonstrate that live firefighting is associated with greater perceived exhaustion than free search or guideline exercises; however, all tasks lead to high cardiovascular demand regardless of the presence of heat. No significant impact of task upon mood and no significant differences between the perceived demands of guideline, free search and live firefighting exercises were found. Practitioner Summary: This study considered the physiological and psychological responses of firefighters undertaking SCBA exercises. Although live firefighting is associated with greater perceived exertion, the absence of differences in psychological domains between exercises demonstrates that task demands are not always dependent upon the presence of fire and that all tasks are mentally challenging.
Hearing: Its Physiology and Pathophysiology

Preface. Introduction. The Ear: A. Anatomy: Anatomy of the Ear. B. Physiology: Sound Conduction to the Cochlea. Physiology of the Cochlea. Electrical Potentials in the Cochlea. The Auditory Nervous System: A. Anatomy: Anatomy of the Auditory Nervous System. B. Physiology: Representation of Frequency in the Auditory System. Temporal or Place Code for Discrimination of Complex Sounds? Coding of Complex Sounds. Hearing with Two Ears. Electrical Potentials in the Auditory Nervous System. Far-field Auditory Evoked Potentials. Acoustic Reflexes: The Acoustic Middle Ear Reflex. Disorders of the Auditory System and their Pathophysiology: A. Conductive Hearing Loss: The Sound Conducting Apparatus. B. Sensorineural Hearing Loss: The Cochlea. The Auditory Nervous System. C. Other Disorders of the Auditory System: Tinnitus and Hyperacusis. Chapter References.
Toward a better understanding of amyotrophic lateral sclerosis.

Ray was a very active child— riding horses, driving go-carts, and playing sports. It was not uncommon for him to come to school with bruises, cuts, and scrapes from his many adventures. He was a standout on the local high school football team. After high school, he served in the Armed Services, then returned to his small hometown. He remained a very active young man in his local community, so it was difficult for all when at the age of 35 years he was diagnosed with amyotrophic lateral sclerosis. To many, the diagnosis was not very meaningful until its more common name—Lou Gehrig’s disease—was linked with Ray’s illness. Avid baseball enthusiasts are familiar with the name Lou Gehrig, The Iron Horse. In the movie, “The Pride of the Yankees,” Gary Cooper took on the role of Gehrig and demonstrated the insidious onset of this devastating neurologic disease. This article presents an overview of amyotrophic lateral sclerosis (ALS), including its etiology, diagnosis, pathophysiology and clinical presentation, and medical and nursing management.
Ion-Solvent Complexes Promote Gas Evolution from Electrolytes on a Sodium Metal Anode.

Lithium and sodium metal batteries are considered as promising next-generation energy storage devices due to their ultrahigh energy densities. The high reactivity of alkali metal toward organic solvents and salts results in side reactions, which further lead to undesirable electrolyte depletion, cell failure, and evolution of flammable gas. Herein, first-principles calculations and in situ optical microscopy are used to study the mechanism of organic electrolyte decomposition and gas evolution on a sodium metal anode. Once complexed with sodium ions, solvent molecules show a reduced LUMO, which facilitates the electrolyte decomposition and gas evolution. Such a general mechanism is also applicable to lithium and other metal anodes. We uncover the critical role of ion-solvent complexation for the stability of alkali metal anodes, reveal the mechanism of electrolyte gassing, and provide a mechanistic guidance to electrolyte and lithium/sodium anode design for safe rechargeable batteries.
Dynamic vibrotactile warning signals for frontal collision avoidance: towards the torso versus towards the head

Three experiments were conducted to assess the effectiveness of dynamic vibrotactile warning signals with different spatial patterns and to compare dynamic towards-torso and towards-head vibrotactile warnings in a simulated driving task. The results revealed that embedding additional stimuli between the participant's hands and waist in the towards-torso cues (Experiment 1) and increasing the spatial distance between adjacent stimuli in the towards-head cues (Experiment 2) did not result in any further benefits in braking response times (BRTs). The triple towards-head cues resulting from the sequential operation of three pairs of stimuli on the torso gave rise to a significant advantage over the static cues; however, it did not outperform the dynamic towards-torso cues with just two pairs of stimuli. Taken together, these results demonstrated the promise of dynamic vibrotactile warnings (especially, the towards-torso warnings) in terms of the future design of more effective rear-end collision warnings. Practitioner Summary: Three experiments assessed the effectiveness of dynamic towards-torso and towards-head vibrotactile warning signals in a simulated driving task. The results demonstrated the promise of dynamic vibrotactile warnings (especially, the towards-torso vibrotactile warnings) in terms of the future design of more effective frontal collision warnings.
Processes and outcomes for acute myocardial infarction patients

Purpose – The purpose of this paper is to determine whether process quality indicators for acute myocardial infarction (AMI) one associated with outcome indicators (hospital mortality and early readmission). Design/methodology/approach – A retrospective cohort study was conducted among patients discharged from three Swiss university hospitals with a primary or secondary International Classification of Diseases, 10th revision (ICD‐10) AMI code in 1999. A total of 1,129 patients' records were abstructed. Demographic characteristics and risk factors at admission were recorded. The main ECG and laboratory findings were further abstracted as well as hospital and discharge management and treatment. The main outcome measure was process quality indicators derived from evidence‐based guidelines, and hospital mortality and early readmissions.Findings – After exclusions, 577 patients with AMI were eligible for this study. The mean (SD) age was 68.2 (13.9). In the assessment of quality indicators patients with potenti.
A decision ladder analysis of eco-driving: the first step towards fuel-efficient driving behaviour

This paper provides a decision ladder analysis of eco-driving, and a discussion of the resultant models in terms of the skills, rules and knowledge taxonomy of human behaviour and how this can inform the design of an in-vehicle, eco-driving support system. In order to understand the types of behaviours that characterise fuel-efficient driving, a review was conducted of the academic literature and of more publicly available resources, such as governmental, car manufacturers' and specific eco-driving organisations' websites. The review identified four largely distinct driving activities that play a central role in the use of fuel in the private road vehicle. A focus group involving four researchers in the transport ergonomics field, followed by a series of five interviews with eco-driving experts, served to validate, supplement and further specify the models. Practitioner Summary: This paper presents a decision ladder analysis of eco-driving. A four-member focus group and five interviews with eco-driving experts were conducted; the resultant models are discussed in terms of supporting fuel-efficient driving behaviours in the novice eco-driver through their potential to inform the design of an in-vehicle eco-driving support system.
Prognosis of Children with Malignant Pheochromocytoma

Malignant pheochromocytomas are rare in childhood and the prognosis of children with this tumor is not well known. We present 2 pediatric observations of malignant pelvic pheochromocytoma. Symptoms in both cases were headache and hypertension. The tumor invaded the sacral bone. Angiogram helped to localize the tumor and metastases, and allowed preoperative embolization of the tumor in 1 case. The first child underwent incomplete surgical resection, 131I-MIBG therapy and radiotherapy, and is still alive 2 years after diagnosis. The second child died from metastatic invasion a few weeks after discovery of the tumor. We reviewed previous reports of children with malignant pheochromocytomas (30 cases). Primary tumor was extraadrenal in 50% of cases. The 3-year survival rate was 73 ± 9% (mean ± SD). Apart from surgical resection, no particular treatment appeared to be more effective than others in reducing mortality.
Importance of gene–environment interactions in the etiology of selected birth defects

It is generally understood that both genetic and environmental factors contribute to the highly complex etiology of structural birth defects, including neural tube defects, oral clefts and congenital heart defects, by disrupting highly regulated embryonic developmental processes. The intrauterine environment of the developing embryo/fetus is determined by maternal factors such as health/disease status, lifestyle, medication, exposure to environmental teratogens, as well as the maternal genotype. Certain genetic characteristics of the embryo/fetus also predispose it to developmental abnormalities. Epidemiologic and animal studies conducted over the last few decades have suggested that the interplay between genes and environmental factors underlies the etiological heterogeneity of these defects. It is now widely believed that the study of gene–environment interactions will lead to better understanding of the biological mechanisms and pathological processes that contribute to the development of complex birth defects. It is only through such an understanding that more efficient measures will be developed to prevent these severe, costly and often deadly defects. In this review, we attempt to summarize the complex clinical and experimental literature on current hypotheses of interactions between several select environmental factors and those genetic pathways in which they are most likely to have significant modifying effects. These include maternal folate nutritional status, maternal diabetes/obesity‐related conditions, and maternal exposure to selected medications and environmental contaminants. Our goal is to highlight the potential gene–environment interactions affecting early embryogenesis that deserve comprehensive study.
Psychometric Properties of the Early Trauma Inventory–Self Report

Childhood trauma is an important public health problem, but there are limitations in our ability to measure childhood abuse. The purpose of this study was to develop a self-report instrument for the assessment of childhood trauma that is valid but simple to administer. A total of 288 subjects with and without trauma and psychiatric disorders were assessed with the Early Trauma Inventory–Self Report (ETI-SR), an instrument for the assessment of physical, emotional, and sexual abuse, as well as general traumas, which measures frequency, onset, emotional impact, and other variables. Validity and consistency of the ETI-SR using different methods of scoring was assessed. The ETI-SR was found to have good validity and internal consistency. No method was found to be superior to the simple method of counting the number of items endorsed as having ever occurred in terms of validity. Some items were found to be redundant or not necessary for the accurate measurement of trauma severity within specific domains. Subsequent analyses with a shortened checklist of items showed acceptable validity and internal consistency. These findings suggest that the ETI-SR is a valid measure of early trauma, and suggest future directions for a shortened version of the ETI-SR that could be more easily incorporated into clinical research studies and practice settings.
Job and Industry Turnover for Registered and Licensed Vocational Nurses

Most studies of nurse turnover focus on job turnover, which could reflect nurse advancement and thus not be detrimental to the workforce. The authors discuss findings from a study that involved 2 cohorts of graduates from registered nursing and licensed vocational nursing community college programs in California. The duration of employment in the healthcare industry, as well as with specific employers, is tracked, lending a more thorough analysis of nursing job and industry turnover than found in other studies.
Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A.

Natural products have historically been a major source of antibiotics and therefore novel scaffolds are constantly of interest. The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogues to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.
A method for predicting the risk of virtual crashes in a simulated driving task using behavioural and subjective drowsiness measures

Abstract This study proposed a procedure for predicting the point in time with high risk of virtual crash using a control chart methodology for behavioural measures during a simulated driving task. Tracking error, human back pressure, sitting pressure and horizontal and vertical neck bending angles were measured during the simulated driving task. The time with a high risk of a virtual crash occurred in 9 out of 10 participants. The time interval between the successfully detected point in time with high risk of virtual crash and the point in time of virtual crash ranged from 80 to 324 s. The proposed procedure for predicting the point in time with a high risk of a crash is promising for warning drivers of the state of high risk of crash. Practitioner Summary: Many fatal crashes occur due to drowsy driving. We proposed a method to predict the point in time with high risk of virtual crash before such a virtual crash occurs. This is done using behavioural measures during a simulated driving task. The effectiveness of the method is also demonstrated.
What do people know about eco-driving?

Abstract An online survey of 321 respondents revealed that the majority of people are aware of eco-driving and have a positive attitude towards it. Although the types of eco-driving tips offered by respondents, and their potential effect on fuel consumption, were in line with those found in the popular and academic literature, knowledge of specific fuel saving behaviours was generally low. Relationships were found between environmental attitudes and knowledge of, and propensity to perform eco-driving behaviours; however, these relationships were weak, indicating that neither pro-environmental attitudes nor knowledge of eco-driving behaviours is strongly indicative of actual eco-driving performance. Males were found to be more knowledgeable of the means for driving in a fuel-efficient manner than females; however, no effect was found for either age or level of general education. Results are discussed in terms of the challenges and opportunities for encouraging eco-driving, and the necessity for both governmental and industry involvement. Practitioner Summary: To successfully encourage the uptake of eco-driving (e.g. through policy, training and feedback) it is first necessary to understand how the general public perceives it, and what they already know of it. This survey study addresses this by looking at relationships between environmental attitudes and knowledge, and specific eco-driving measures.
Procedure and information displays in advanced nuclear control rooms: experimental evaluation of an integrated design

Abstract In the main control rooms of nuclear power plants, operators frequently have to switch between procedure displays and system information displays. In this study, we proposed an operation-unit-based integrated design, which combines the two displays to facilitate the synthesis of information. We grouped actions that complete a single goal into operation units and showed these operation units on the displays of system states. In addition, we used different levels of visual salience to highlight the current unit and provided a list of execution history records. A laboratory experiment, with 42 students performing a simulated procedure to deal with unexpected high pressuriser level, was conducted to compare this design against an action-based integrated design and the existing separated-displays design. The results indicate that our operation-unit-based integrated design yields the best performance in terms of time and completion rate and helped more participants to detect unexpected system failures. Practitioner Summary: In current nuclear control rooms, operators frequently have to switch between procedure and system information displays. We developed an integrated design that incorporates procedure information into system displays. A laboratory study showed that the proposed design significantly improved participants’ performance and increased the probability of detecting unexpected system failures.