Miracle-dz/UniFAR-FTUs huggingface dataset:
Fluorescent analogues of Human -Calcitonin Gene-Related Peptide with vasodilator potency

: Human α -calcitonin gene-related peptide (h- α -CGRP) is a highly potent vasodilator peptide that belongs to the family of calcitonin peptides. There are two forms of CGRP receptors in humans and rodents: α -CGRP receptor predominately found in the cardiovascular system and β -CGRP receptor predominating in the gastrointestinal tract. The CGRP receptors are primarily localized to C and A δ sensory ﬁbers, where they are involved in nociceptive transmission and migraine pathophysiology. These ﬁbers are found both peripherally and centrally, with extensive perivascular location. The CGRP receptors belong to the class B G-protein-coupled receptors, and they are primarily associated to signaling via G α proteins. The objectives of the present work were: (i) synthesis of three single-labelled ﬂuorescent analogues of h- α -CGRP by 9-ﬂuorenylmethyloxycarbonyl (Fmoc)-based solid-phase peptide synthesis, and (ii) testing of their biological activity in isolated human, mouse, and rat arteries by using a small-vessel myograph setup. The three analogues were labelled with 5(6)-carboxyﬂuorescein via the spacer 6-aminohexanoic acid at the chain of Lys 24 or Lys 35 . Circular dichroism (CD) experiments were performed to obtain information on the secondary structure of these ﬂuorescently labelled peptides. The CD spectra indicated that the folding of all three analogues was similar to that of native α -CGRP. The three ﬂuorescent analogues of α -CGRP were successfully prepared with a purity of > 95%. In comparison to α -CGRP, the three analogues exhibited similar e ﬃ cacy, but di ﬀ erent potency in producing a vasodilator e ﬀ ect. The analogue labelled at the N-terminus proved to be the most readily synthesized, but it was found to possess the lowest vasodilator potency. The analogues labelled at Lys 35 or Lys 24 exhibited an acceptable reduction in potency (i.e., 3–5 times and 5–10 times less potent, respectively), and thus they have potential for use in further investigations of receptor internalization and neuronal reuptake. cient [M]),
1.21 The Lateral Geniculate Nucleus and Pulvinar

1.21. 1 Abstract 369 1.21. 2 Introduction 369 1.21. 3 Thalamic Cell Types 370 1.21. 4 Cell Properties 370 1.21. 4.1 Properties of Naþ and Kþ channels Underlying the Action Potential 371 1.21. 4.2 Properties of T-type Ca2þ Channels 373 1.21. 4.3 Properties of Burst and Tonic Firing 373 1.21. 4.4 Hypothesis for Burst and Tonic Firing 375 1.21. 5 Lateral Geniculate Nucleus 375 1.21. 5.1 Anatomical Features 375 1.21. 5.2 Functional Features 376 1.21. 5.2. 1 Ionotropic and Metabotropic Receptors 377 1.21. 5.2. 2 Role of Inputs From Brainstem Reticular Formation and Layer 6 of Cortex 378 1.21. 5.3 Parallel Processing 379 1.21. 5.3. 1 X and Y Cells 379 1.21. 5.3. 2 W Cells 379 1.21. 5.4 The Monkey Lateral Geniculate Nucleus 379 1.21. 5.4.1 P and M Cells 379 1.21. 5.4.2 K Cells 380 1.21. 5.5 Laminar Relationships of the Lateral Geniculate Nucleus 380 1.21. 6 Visual Cortex 381 1.21. 7 Glutamatergic Drivers and Modulators 381 1.21. 7.1 Glutamatergic Drivers and Modulators in Thalamus 381 1.21. 7.2 Glutamatergic Drivers and Modulators in Cortex 382 1.21. 7.3 Purpose of Glutamatergic Modulators 383 1.21. 8 First and Higher Order Relays: The Lateral Geniculate Nucleus and Pulvinar 384 1.21. 9 Branching of Driver Afferents to Thalamus 385 1.21. 10 Role of Higher Order Thalamic Relays in Corticocortical Processing 385 1.21. 11 Overview 387 1.21. 12 Conclusions 388 Acknowledgments 388 References 388
Development and Ultrastructure of Cotesia plutellae (Kurdjumov) teratocytes.

The endoparasitic parasitoid Cotesia plutellae (Kurdjumov) develops in the hemocoele of larval stages of the diamondback moth Plutella xylostella (Linnaeus) Teratocytes were released from the serosal membrane during hatching of the first instar parasitoid at 3336 h after oviposition when held at (25±1)℃; An average of 192 cells were released per embryo,the cells increased in diameter from about (1531±306)μm to (6325±1265)μm, but some of the teratocytes attained a size of the biggest 11875 μm. The number of teratocytes,however, declined during the course of parasitoid developmentScanning electron microscope(SEM) revealed that the surface of the teratocytes was covered with microvilli,which on the 4th day was much denser and longer than on the 1st day. This implied that they were actively involved in functions of absorption and secretionTransmission electron microscope(TEM) revealed that mature teratocyte nucleus developed extensive dentritic ramification, and was endowed with the extensive endoplasmic reticulum, abundant mitochondria and increasing number of lysosome, also observed were the accumulation of glycogen granules and lipid droplets, especially, in older teratocytes, thus providing circumstantial evidence for the occurrence of protein synthesis and secretion
The macroeconomic factors affecting government bond yield in Indonesia, Malaysia, Thailand, and the Philippines

The government bond (GB) has become the most attractive investment portfolio option, even though many macroeconomic factors affect the bond yield. This paper aims to investigate the determining factor of local currency government bond yield by considering the inflation rate, credit default swap, stock market index, exchange rate, and volatility index. This study used 240 data panel from the Bloomberg stock market in the form of data panel covering Southeast developing countries, namely Indonesia, Thailand, Malaysia, and the Philippines, for five years or sixty months from January 2015 to December 2019. Data analysis used recursive models and multivariate regression techniques using EViews software. The random effect model results revealed that change in the foreign exchange rate and volatility indexes affected, partially and simultaneously, the changes in the stock market index. The result also showed that changes in the stock market index, inflation rate, and credit default swap affected, partially and simultaneously, government bond yield changes. These results suggest that the government bond yield could be managed by controlling volatility index, foreign exchange rate, stock market index, inflation rates, and credit default swaps. This finding could provide an insight into the policymaker and fiscal authority on managing the risk of government bonds under control during high volatility or even making it reasonably lower. This result could contribute to the current research in the field of financial management. Acknowledgment It is the author’s pleasure to thank Muhammad Aulia SE MSc CSA® from the Ministry of Finance of Republic Indonesia, for his invaluable contribution to encourage this study and also to share the data required for this paper. He also delivers essential insights into improving the quality of this work. This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
Matrix completion for matrices with low-rank displacement

The matrix completion problem consists in the recovery of a low-rank or approximately low-rank matrix from a sampling of its entries. The solution rank is typically unknown, and this makes the problem even more challenging. However, for a broad class of interesting matrices with so-called displacement structure, the originally ill-posed completion problem can find an acceptable solution by exploiting the knowledge of the associated displacement rank. The goal of this paper is to propose a variational non-convex formulation for the low-rank matrix completion problem with low-rank displacement and to apply it to important classes of medium-large scale structured matrices. Experimental results show the effectiveness and efficiency of the proposed approach for Toeplitz and Hankel matrix completion problems.
DO BUSINESS STUDENTS HAVE MORE EFFECTIVE LEARNING STRATEGIES THAN STUDENTS FROM OTHER ACADEMIC FIELDS ?

The aim of this paper is to compare the learning strategies of students in different academic fields in higher education. Previous research has limited its focus to comparing students on topics such as the degree of social responsibility, personal values, academic dishonesty/integrity, and emotional intelligence. In contrast, this study addresses the issue of whether the learning strategies of business students are better than those of students from other academic fields. To date, our knowledge and understanding of this issue are limited even though the topic of learning strategies has gained considerable attention in educational research. This research applied the Learning and Study Strategies Inventory (LASSI) to elucidate the differences in study strategies between groups of students. Findings from the statistical analysis indicate that business students have more effective learning strategies than the non-business students included in this study. Potential reasons for these findings are discussed and based on these findings theoretical and practical implications are viewed.
Peer Support to Reduce Vicarious Trauma in Mental Health Providers

Background and Review of Literature: Mental health providers working with individuals with trauma and stress are at increased risk for vicarious trauma (VT) and compassion fatigue. Purpose: To institute a peer support group for mental health providers with the goal of preventing the negative sequelae associated with vicarious trauma. Methods: A quality improvement project was implemented with six mental health providers engaged in weekly peer support group sessions lead by the DNP student over a six week timeframe. Topics discussed included education on vicarious trauma, client case vignettes, and mindfulness around the treatment of vicarious trauma. Professional quality of life (ProQOL) and secondary traumatic stress (STSS) assessments were completed prior to the start of the peer group and at the completion of the sixth group. Results: Analysis of post group assessment results demonstrated a strong agreement by 67% that peer support is necessary. Additional findings from the peer support groups concluded that connection and the sense of feeling less alone was beneficial, resulting in more clinic camaraderie and individual confidence with patient care. The mental health providers also felt supported by their leadership as a result of their participation. Conclusion: The results of this quality improvement project demonstrate that peer support groups may reduce provider burnout and vicarious trauma and increase compassion satisfaction.
HYBRIDIZATION, HOMOGAMY, AND SYMPATRIC SPECIATION

Mayr (1947) has presented a strong case against the hypothesis of sympatric speciation in the course of supporting the universal hypothesis of geographic (or at least microgeographic) speciation. In the summary (p. 286) of that paper he made the following statement: "It is unproven and unlikely that reproductive isolation can develop between contiguous populations. " Later, Grant (1949), in a discussion of pollination systems as isolating mechanisms, presented a model for sympatric speciation in angiosperms dependent on the known flower constancy of bees. This model indicated the means by which an important mutation in flower color or form might become established within a population, thus resulting in time in a new and well isolated species to which internal isolating mechanisms are unnecessary. In passing, the latter author suggested that hybridization might also provide an example of sympatric speciation. It is the purpose of the present paper to further develop this last hypothesis on the basis of a realistic model suggested by recent studies of hybridization and floral isolation in a group of Penstemon species. It is not the purpose of this paper to refute the general conclusions reached by Mayr (I.c.) on the importance of geographic speciation, but merely to indicate that sympatric speciation may be less unlikely than previously considered. The word, species, is here used in its biological sense.
Total Body Electrical Conductivity (TOBEC): A Tool to Estimate Lean Mass and Nonpolar Lipids of an Aquatic Organism?

of the alarm responses of Bufo boreas and Rana cascadae tadpoles. Behav. Neural Biol. 43:47-57. KATS, L. B. 1988. The detection of certain predators via olfaction by smallmouthed salamander larvae (Ambystoma texanum). Behav. Ibid. 50:126-131. 1, J. W. PETRANKA, AND A. SIH. 1988. Antipredator defenses and the persistence of amphibian larvae with fishes. Ecology 69:1865-1870. LAWLER, S. P. 1989. Behavioral responses to predation risk in four species of larval amphibians. Anim. Behav. 38:1039-1047.
MICROWAVE PHOTONICS APPROACHES FOR 5G STANDARD

The aim of this Final Degree Thesis is to present diverse systems for the generation of microwave signals through the utilization of microwave photonic techniques with the intention of being employed in the new standard 5G. For the simulation work, VPI photonics simulation platform software has been utilized. All the designs are based on the use of a Mach-Zehnder modulator biased at the minimum transmission point to generate the signal. A design based on this method is employed to transmit NRZ OOK data at 10 Gbps over a 30 GHz signal by an oscillator which beams a 15 GHz signal. The system is compared with one which does not make use of microwave photonic techniques giving a satisfactory result both in the behavior and the cost. Additionally, other alternatives that utilize the Stimulated Brillouin Scattering (SBS) to increment the carrier frequency without increasing the oscillator frequency are presented. Lastly, a scheme that also make use of SBS is demonstrated to be able to generate triangularshaped pulses at 5,8 and 10 GHz; and a design with two lasers is also demonstrated, achieving an enhanced flexibility in the tunability.
invited review Renal Na 1 -glucose cotransporters

Na -glucose cotransporters. Am J Physiol Renal Physiol 280: F10–F18, 2001. —In humans, the kidneys ﬁlter ; 180 g of D -glucose from plasma each day, and this is normally reabsorbed in the proximal tubules. Although the mechanism of reabsorption is well understood, Na 1 -glucose cotransport across the brush-border membrane and facilitated diffusion across the basolateral membrane, questions remain about the identity of the genes responsible for cotransport across the brush border. Genetic studies suggest that two different genes regulate Na 1 -glucose cotransport, and there is evidence from animal studies to suggest that the major bulk of sugar is reabsorbed in the convoluted proximal tubule by a low-afﬁnity, high-capacity transporter and that the remainder is absorbed in the straight proximal tubule by a high-afﬁnity, low-capacity transporter. There are at least three different candidates for these human renal Na 1 -glucose cotransporters. This review will focus on the structure-function relationships of these three transporters, SGLT1, SGLT2, and SGLT3.
Improvement of Photocatalytic Performance for the g-C3N4/MoS2 Composite Used for Hypophosphite Oxidation

The synthesized g-C3N4/MoS2 composite was a high-efficiency photocatalytic for hypophosphite oxidation. In this work, a stable and cheap g-C3N4 worked as the chelating agent and combined with the MoS2 materials. The structures of the fabricated g-C3N4/MoS2 photocatalyst were characterized by some methods including X-ray diffraction (XRD), scanning electron microscopy (SEM), and X-ray photoelectron spectra (XPS). Moreover, the photocatalytic performances of various photocatalysts were measured by analyzing the oxidation efficiency of hypophosphite under visible light irradiation and the oxidation efficiency of hypophosphite using the g-C3N4/MoS2 photocatalyst which was 93.45%. According to the results, the g-C3N4/MoS2 composite showed a promising photocatalytic performance for hypophosphite oxidation. The improved photocatalytic performance for hypophosphite oxidation was due to the effective charge separation analyzed by the photoluminescence (PL) emission spectra. The transient photocurrent response measurement indicated that the g-C3N4/MoS2 composites (2.5 μA cm–2) were 10 times improved photocurrent intensity and 2 times improved photocurrent intensity comparing with the pure g-C3N4 (0.25 μA cm–2) and MoS2 (1.25 μA cm–2), respectively. The photocatalytic mechanism of hypophosphite oxidation was analyzed by adding some scavengers, and the recycle experiments indicated that the g-C3N4/MoS2 composite had a good stability.
Management of proximal tibial fractures by posteromedial locking compression plate

Management of tibial plateau fractures aims to restore normal knee functionality by near normal anatomical restoration of the articulating surfaces, thereby maintaining the mechanical axis and restoring ligamentous stability. Plate fixation is important when a medial plateau is involved in proximal tibial fractures. The present study was designed to assess the management of medial condylar fractures of proximal tibia treated by posteromedial locking compression plate. A total of 30 cases with Schatzker type IV-VI fractures to the proximal tibia, who followed up for clinic radiological evaluation, between age group 20-60 years were recruited. Clinical examination and radiological investigations were performed to review the fractures. The fractures to the medial condyle of tibia were treated by posteromedial approach. Post-operative care has been initiated with physical therapy in the form of quadriceps exercises. The postoperative follow up was continued at the end of one month, three months and six months and outcomes were recorded by using Lysholm knee score. According to Schatzker type of fractures 46.6% had type IV, 33.3% had type V and 20% had type VI fractures. Majority cases had fractures due to road traffic accidents (70%). Postoperative fracture outcome showed excellent outcome in 78% cases, good results in 16%, fair results in 6% and none of the case had a poor outcome. In postoperative complications, 80% cases were recovered without complications, 10% cases had superficial infection, 7% cases had knee pain, and 3% cases had knee stiffness. The posteromedial approach of tibial fracture management is safe with minimal complications. Fixation of posteromedial tibia permits quick reformation of the patient with outstanding functional outcome with minimal incidence of complication.
Proactive Risk Mitigation and Reactive Control for Safe and Smooth Automated Driving

In addition to predictable static and dynamic objects on public roads, automated driving systems must also handle unpredictable hazards such as parked car doors opening, cyclists falling, or pedestrians stepping off curbs. One extreme approach would be to plan such that all hazards would come to pass, though this results in an uncomfortably conservative system. Another extreme approach would be to perform aggressive reactive maneuvers when hazards materialize, though this results in an uncomfortably reactive system. This paper proposes a robust approach that handles hazards through proactive planning and reactive control to achieve a smooth and safe automated driving (AD) while enabling the use of lower cost sensors.
Establishment of AIRS climate-level radiometric stability using radiance anomaly retrievals of minor gases and sea surface temperature

Abstract. Temperature, H2O , and O3 profiles, as well as CO2 , N2O , CH4 , chlorofluorocarbon-12 (CFC-12), and sea surface temperature (SST) scalar anomalies are computed using a clear subset of AIRS observations over ocean for the first 16 years of NASA's Earth-Observing Satellite (EOS) Aqua Atmospheric Infrared Sounder (AIRS) operation. The AIRS Level-1c radiances are averaged over 16 d and 40 equal-area zonal bins and then converted to brightness temperature anomalies. Geophysical anomalies are retrieved from the brightness temperature anomalies using a relatively standard optimal estimation approach. The CO2 , N2O , CH4 , and CFC-12 anomalies are derived by applying a vertically uniform multiplicative shift to each gas in order to obtain an estimate for the gas mixing ratio. The minor-gas anomalies are compared to the National Oceanic and Atmospheric Administration (NOAA) Earth System Research Laboratory (ESRL) in situ values and used to estimate the radiometric stability of the AIRS radiances. Similarly, the retrieved SST anomalies are compared to the SST values used in the ERA-Interim reanalysis and to NOAA's Optimum Interpolation SST (OISST) product. These intercomparisons strongly suggest that many AIRS channels are stable to better than 0.02 to 0.03 K per decade, well below climate trend levels, indicating that the AIRS blackbody is not drifting. However, detailed examination of the anomaly retrieval residuals (observed – computed) shows various small unphysical shifts that correspond to AIRS hardware events (shutdowns, etc.). Some examples are given highlighting how the AIRS radiance stability could be improved, especially for channels sensitive to N2O and CH4 . The AIRS shortwave channels exhibit larger drifts that make them unsuitable for climate trending, and they are avoided in this work. The AIRS Level 2 surface temperature retrievals only use shortwave channels. We summarize how these shortwave drifts impacts recently published comparisons of AIRS surface temperature trends to other surface climatologies.
On a Truncated Erlangian Queueing System with State – Dependent Service Rate, Balking and Reneging

The aim of this paper is to derive the analytical solution of the truncated Erlangian service queue with state-dependent rate, balking and reneging (M/ER/I/N ( β α , )) . We obtain s n P , , the probabilities that there are "n" units in the system and the unit in the service occupces stage "s" (s = 1, 2,., r ) . We treat this queue for general values of r , k and N.
The Arabidopsis thaliana Heat Shock Transcription Factor A1b Transcriptional Regulatory Network

Plants as sessile organisms have adapted highly sophisticated cellular processes to cope with environmental stress conditions, which include the initiation of complex transcriptional regulatory circuits. The heat shock transcription factors (HSFs) have been shown to be central regulators of plant responses to abiotic and biotic stress conditions. However, the extremely high multiplicity in plant HSF families compared to those of other kingdoms and their unique expression patterns and structures suggest that some of them might have evolved to become major regulators of other non-stress related processes. Arabidopsis thaliana HSFA1b (AtHSFA1b) has been shown to be a major regulator of various forms of plant responses to abiotic and biotic stresses. However, it has also been suggested that overexpression of AtHSFA1b results in a subtle developmental effect in Arabidopsis thaliana and Brassica napus in the form of increased seed yield and harvest index. Through genome-wide mapping of the AtHSFA1b binding profile in the Arabidopsis thaliana genome, monitoring changes in the AtHSFA1b-regulated-transcriptome, and functional analysis of AtHSFA1b in Saccharomyces cerevisiae under non-stress and heat stress conditions, this study provides evidence of the association of AtHSFA1b with plant general developmental processes. Furthermore, the outcome of this research shows that AtHSFA1b controls a transcriptional regulatory network operating in a hierarchical manner. However, in an agreement with a previously suggested model, the results from this study demonstrate that the involvement of AtHSFA1b in the regulation of heat stress response in Arabidopsis thaliana is possibly limited to the immediate and very early phases of heat stress response which also results in a collapse in its transcriptional network which seems to be accompanied by a general shutdown in plant growth and development.