Miracle-dz/UniFAR-FTUs huggingface dataset:
Update on pediatric systemic lupus erythematosus

Purpose of review The purpose of this review is to provide an update on the clinical manifestations of SLE in children. Emerging clues on the pathogenesis of the disease based on recent human studies conducted both in children and adults, will also be summarized. Recent findings Pediatric Rheumatologists caring for children with SLE face many challenges. As the life expectancy of these patients improves, new recognized complications such as accelerated atherosclerosis and hypertension emerge as major causes of morbidity. However, few longitudinal studies describing the long term outcome of these children, including the impact of disease and treatment on their physical and psychological development are available. Few prospective interventional studies have been carried out to assess the efficacy of established and novel treatments in the pediatric population. Recently, basic studies aimed at understanding the immune alterations underlying this disease have been performed in children. These studies indicate an important role for interferon-alpha (IFN-α) in the pathogenesis of this disease and reveal an overall striking homogeneity of leukocyte gene expression profiles in children and adults with SLE. The contribution of novel gene polymorphisms to disease susceptibility and the sequential breakdown of tolerance to nuclear antigens that precedes clinical manifestations in patients with SLE are among the recent studies that are helping us understand the complex SLE puzzle. Summary SLE continues to cause significant morbidity in the pediatric age group. A better recognition of the age-specific manifestations and long-term complications of this disease is required to improve its outcome. Understanding its unique pathogenesis will hopefully lead to the development of better, more targeted and less toxic therapies.
Effects of the correlation model, the trend model, and the number of training points on the accuracy of Kriging metamodels

This paper explores the effects of the correlation model, the trend model, and the number of training points on the accuracy of Kriging metamodels. Gaussian correlation models are found to be superior to exponential and linear correlation models. No particular trend model is found to be better than the other models. The number of training points used in constructing the Kriging metamodels is observed to change the relative performances of the trend and the correlation functions. The leave‐one‐out cross‐validation error is found to become a better surrogate for the actual error, as the number of training points is increased. Finally, the use of an ensemble of metamodels is discussed and it is found that using an ensemble may improve the accuracy.
The transition from maternal to zygotic control of development occurs during the 4-cell stage in the domestic pig, Sus scrofa: quantitative and qualitative aspects of protein synthesis.

A study was conducted to identify the embryonic stage when the zygotic genome begins to direct development and to characterize protein synthesis in pig oocytes and embryos. Reproductive tracts of gilts were flushed to obtain unfertilized oocytes (UFO), zygotes (Z), 2-, 4-, and 8-cell embryos, compact morulae (M), initial blastocysts (IB), blastocysts (B), and hatched blastocysts (HB). Pig eggs and embryos were cultured in medium containing 1 microM L-[35S]methionine and evaluated for amino acid uptake, incorporation of the radiolabel into protein, and qualitative changes in protein profiles specific to each cleavage stage. Unfertilized oocytes sequestered 65.7 fmol methionine/4 h/embryo. Uptake of methionine decreased (p less than 0.05) from the Z (49.4), 2-cell (41.8), and 4-cell (37.6) embryonic stages to the M (8.97 fmol/4 h/embryo) stage. This downward trend was reversed at the IB, B, and HB stages when uptake increased to 37.3, 50.3, and 84.2 fmol/4 h/embryo, respectively. Incorporation of methionine into protein followed a similar pattern, being relatively higher in the UFO (21.0), Z (20.5), and 2-cell stages (16.0); decreased (p less than 0.05) at the 4-cell (6.67), 8-cell (6.84), and M (6.16) stages; and increased (p less than 0.05) at the IB (28.0), B (41.5), and HB (69.6 fmol/4 h/embryo) stages. Differences in protein profiles were observed for UFO, Z, 4-cell, and M stages using lysates of single embryos, one-dimensional SDS-PAGE, and fluorography. (ABSTRACT TRUNCATED AT 250 WORDS)
Melon sensitivity shares allergens with Plantago and grass pollens

Possible associations between allergy to pollen and that to food allergens were studied in 262 patients sensitized to pollen. Forty‐four patients (16.7%) showed some allergic symptoms after testing with fruits and vegetables, melon being the food most frequently involved (24 patients), followed by sunflower seed (12 patients). Skin testing was done by the prick method with natural fruit or vegetable, and also with commercial food extracts. We found in our region that the distribution of sensitivity to pollens in the group of patients with allergy to fruits or vegetables does not coincide with the prevalence in pollen‐allergic subjects in general, since in the first group ‐subjects allergic to food ‐ there was a major prevalence of allergy to Plantago (P < 0.01). In particular, in the group of subjects allergic to melon, the prevalence of sensitivity to grass and especially to Plantago was larger than in pollen‐allergic subjects in general (P < 0.05 and P 0.001, respectively). The use of fresh food produced better results than commercial extracts. A positive skin test to fresh melon closely correlated with positive CAP results. CAP inhibition experiments were carried out, and we found that Dactylis and Plantago extracts inhibited the binding of the melon‐positive pool to solid‐phase melon. The results suggest the existence of common antigenic epitopes in melon and Plantago pollen, and in melon and grass pollen.
Title Self make-up : the influence of self-referential processing onattention orienting

Right This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ Type Journal Article
Reading Abilities in Deaf Children: Respective and/or Combined Contribution of Early Age of Cochlear Implantation and Exposition to Cued Speech

Background Deaf children typically exhibit literacy difficulties (Chamberlain & Mayberry, 2000; Dyer et al., 2003). The main reason is that phonological processing is critical in reading (for reviews, see Castles & Coltheart, 2004), even for deaf individuals. Nevertheless, deaf persons can have access to phonological information via different modalities (Campbell & Dodd, 1980; Campbell et al., 1998; McGurk & Mac Donald, 1976) such as auditory modality (hearing aid, cochlear implant) and visual modality (speechreading, cued speech1). There is now a substantial body of evidence showing that different new aids such as Cochlear Implantation (‘CI’/ auditory modality) and
Heritability and clinical features of multigenerational families with obsessive‐compulsive disorder and hoarding

To date, only one complete genome screen for obsessive‐compulsive disorder (OCD) has been published. That study identified a region of suggestive linkage (maximum lod score of 2.25) with a relatively small sample size (N = 56; 27 with OCD). Additional complete genome screens are needed to confirm this finding and identify other regions of linkage. We present the clinical characteristics and power to detect linkage of 11 multigenerational families with OCD and hoarding (N = 92; 44 with OCD), as well as heritability estimates for several quantitative traits. Families with at least two individuals with OCD were identified through probands with childhood‐onset OCD. Expected lod scores were calculated for simulated genetic marker data under an additive and two dominant models assuming a dense SNP marker map. All affected individuals had an early age of onset (18 or younger). Hoarding was present in 46% of subjects. Obsessive‐compulsive symptoms and hoarding were highly heritable. The maximum mean expected lod score was 3.31 for OCD and 1.39 for hoarding. We found reasonable power to detect regions of interest (lod = 2) for OCD in these families, but will need to expand our family collection to have adequate power to detect regions of interest for hoarding. © 2007 Wiley‐Liss, Inc.
ISOLATION AND PRELIMINARY CHARACTERISTICS OF THREE BACTERIOPHAGES ASSOCIATED WITH A LYSOGENIC STRAIN OF PSEUDOMONAS AERUGINOSA,

Feary, Thomas W. (Tulane University School of Medicine, New Orleans, La.), Earl Fisher, Jr., and Thelma N. Fisher. Isolation and preliminary characteristics of three bacteriophages associated with a lysogenic strain of Pseudomonas aeruginosa. J. Bacteriol. 87:196–208. 1964. —Three bacteriophages designated 7v, 7m, and 7s were isolated from a lysogenic strain of Pseudomonas aeruginosa designated Ps-7. The three viruses were found to be completely unrelated on the basis of plaque morphology, host range, serology, ultraviolet induction, sensitivity to heat, and particle morphology as revealed by electron microscopy. In addition, it was shown that the three phages were incapable of plaque formation on bacteria other than various strains of P. aeruginosa. Of the three phages, only phage 7v was capable of plaque formation on strain Ps-7. The growth of phage 7v on strain Ps-7 exhibited properties which suggest that this virus arises as the result of mutation in a temperate phage for which strain Ps-7 is lysogenic. Phages 7m and 7s are incapable of plaque formation on strain Ps-7, but are adsorbed at characteristic rates to cell suspensions of strain Ps-7. The relationship between phage 7m and strain Ps-7 was shown to meet the classical criteria for lysogeny. Because phage 7s contains ribonucleic acid as its nucleic acid component, it was concluded that its production by strain Ps-7 and the demonstration of immunity of strain Ps-7 to infection by phage 7s were not sufficient evidence to define the nature of the relationship between phage 7s and P. aeruginosa strain Ps-7. It was observed that under certain conditions the infectious titer of phage 7s preparations are markedly reduced in the presence of ribonuclease.
Is determination of the hepatic iron index of diagnostic value in patients with thalassemia minor and chronic alcoholic liver disease?

We read with interest the article by Hasan et al. (1) describing the prevalence of hepatitis C antibody (anti-HCV) as detected by the first-generation ELISA test in American patients with HCC. Among 59 patients with HCC who were HBsAg negative and had no evidence of known causes of liver damage, 20 (34%) were anti-HCV-positive. The authors suggested that a more sensitive second-generation test could detect hepatitis C antibodies in some more patients. This appears, in fact, to be the case, according to our recent findings. We have evaluated the profile of anti-HCV positivity by ELISA and RIBA in 40 consecutive cases of HCC (all linked to cirrhosis) using the firstand secondgeneration assays (Ortho Diagnostics Systems, Raritan NJ; and Chiron Corp., Emeryville, CAI. Using the second-generation recombinant immunoblot assay, our patients were analyzed for reactivity with newly identified HCV epitopes, which are different from those (C-100; 5-1-1) used in first-generation assays and correspond to a structural nucleocapsid antigen (C22-3) and to a nonstructural antigen (C33-c). On the basis of the results obtained, patients could be classified in the following groups: (a) anti-HCV-negative cases (14 cases, 35%), without reactivity on firstor second-generation assay; (b) anti-HCV-positive but reactive only with C33c and C22-3 by RIBA (14 cases, 35%) (these cases were negative or only borderline positive on first-generation anti-HCV ELISA assay); and (c) anti-HCV-positive and
Design of a 3.1–10.6-GHz low-power CMOS low-noise amplifier for ultra-wideband receivers using standard 0.13 µm CMOS technology

In this paper, we present an ultra-wideband 3.1–10.6 GHz low-noise amplifier employing an input three-section Elliptic filter to achieve broadband input matching. The flat gain of the LNA is achieved by the inductor peaking load. The LNA is designed in the standard 0. 13µm CMOS technology. It achieved forward gain (S21) around 10 dB, input return loss (S11) of −9.8 dB, noise figure (NF) of 3.5 dB, input third-order-intercept point (IIP3) of 0.6 dBm, 1-dB compression point (P1dB) of −7.9 dBm, good phase linearity property (group-delay-variation is only ±9.4 ps), operates from 1.2 V power supply and consuming 5.4 mW.
Plasmonen in einzelnen oxidgetragenen Edelmetallpartikeln

Plasmon excitations in nanoscopic metal particles lead to an element specific resonant behaviour in their optical properties, in particular for noble metals. This behaviour is used here to gain information on the alloying process of silver and gold. Optical properties of single supported clusters are obtained from scanning tunneling microscopy (STM) combined with optical emission spectroscopy. In the experiments, the STM tip is placed above a chosen cluster, which is excited by electron injection followed by photon emission. The emitted light is analysed using a spectrograph and detected by a CCD chip. The 5-10 nm sized clusters are deposited on an ultrathin, ordered alumina film on a NiAl(110) single crystal. The optical spectra are compared to model calculations based on Mie theory. From this comparison, the observed light emission can be attributed to the radiative decay of the perpendicular (1,0)-mode of a Mie plasmon resonance. It was further shown that simultaneous deposition of the two noble metals, silver and gold, leads to a complete mixing of both materials in the single particles. By successive deposition, clusters grow in a shell-core structure, whereby the metal deposited first forms the core. For gold-shell/silver-core clusters a strong intermixing of core and shell materials is found, explained by a higher mobility of the silver atoms. The relaxation dynamics of plasmons in single noble metal particles is analysed employing time-resolved two-photon photoemission by means of femtosecond laser pulses and photoemission electron microscopy. With this newly implemented approach, 500 nm sized silver particles on a silicon wafer are analysed. Plasmon modes oriented perpendicular (1,0) and parallel (1,1) to the sample surface can be excited by varying the polarisation direction of the laser pulses. Excitation of the (1,0)-mode results in a much stronger photoemission yield due to the resonant excitation of this plasmon mode. Furthermore, the photoemission signal varies in intensity and line width for the different particles, which is due to their size and shape distributions leading to different resonance properties. The experiments presented here demonstrate the possibility to perform optical emission spectroscopy on individual supported metal clusters and to characterise their optical properties regarding size, shape and chemical composition. Furthermore, the implemented time-resolved photoemission electron microscopy allows an investigation of plasmon excitations in single metal particles in space and time.
Early Genes Required for Salivary Gland Fate Determination and Morphogenesis in Drosophila melanogaster

Studies of Drosophila salivary gland formation have elucidated the regulatory pathway by which the salivary gland fate is determined and the morphogenetic processes by which the primordial cells are internalized to form the tubular glands. Both the position of the salivary primordia and the number of cells recruited to a salivary gland fate are established through a combination of the localized expression of the transcription factors SEX COMBS REDUCED (SCR), TEASHIRT (TSH) and ABDOMINAL-B (ABD-B), and localized DPP-signaling. Similarly, the distinction between the two major cell types, duct and secretory, is determined by spatially limited EGF-signaling. Salivary gland formation also requires the function of two transcription factors expressed in nearly all cells of the developing embryo, EXTRADENTICLE (EXD) and HOMOTHORAX (HTH). Once the salivary gland fate is determined, cells of the secretory primordia are internalized by an apical constriction mode of invagination. We have characterized three genes encoding transcription factors, trachealess (trh), hückebein (hkb), and fork head (fkh), that are downstream targets of the salivary gland regulators. Mutations in these transcription factors profoundly affect salivary gland morphogenesis. trh is required for the formation of the salivary duct tubes. hkb determines the order of secretory cell invagination, a regulated process critical for determining the final shape of the salivary gland. fkh has two early roles in salivary gland formation. fkh both promotes secretory cell survival and facilitates secretory cell internalization. trh, hkb, and fkh are involved in the formation of not only the salivary duct and secretory tubes, but also of other tubular structures, such as the trachea and the gut endoderm. We propose that trh, hkb, and fkh may serve as "morphogenetic cassettes" responsible for forming tubular structures in a variety of tissues.
Interior Permanent Magnet Synchronous Motor Linear Field-Weakening Control

At nonlinear field-weakening control of interior permanent magnet synchronous motor (IPMSM), the working point is difficult to calculate and the saturation of current regulators may lead to losing control. Linear field-weakening control (LFC) of IPMSM is proposed to control both torque and current in wide speed range applications and LFC can prevent loosing current control in IPMSM. IPMSM operation range is divided into three areas, namely constant torque linear area, constant power transition linear area, and constant direct axis current area. Current, speed, and torque of the three areas are obtained while maintaining the current and voltage constraints. Currents are controllable and the system can operate in deep field-weakening. Results are used to calculate the IPMSM working points. The validity of this study is verified by experiments.
Immunohistochemical Analysis of hSNF5/INI1 in Pediatric CNS Neoplasms

Atypical teratoid/rhabdoid tumor (AT/RT) may be misdiagnosed as primitive neuroectodermal tumor/medulloblastoma (PNET) and occasionally as other tumors. Molecular genetic analysis of AT/RT demonstrates deletion and mutation of the hSNF5/INI1 gene in most cases, with decreased or absent expression at the RNA or protein level. Immunohistochemistry with an antibody to INI1 was performed to determine whether this would be a sensitive and specific means of assessing INI1 loss in pediatric brain tumors. Fifty-three tumors consisting of 20 AT/RTs, 10 PNETs, and 23 other central nervous system tumors were examined. No nuclear staining was found in all 20 AT/RTs. Most other central nervous system tumors demonstrated nuclear staining. Eight cases in which classification as AT/RT or PNET was difficult were also examined. Seven cases had no chromosome 22 deletion or INI1 mutation; INI1 antibody showed nuclear staining in these cases. One case was a recurrent tumor with features consistent with an AT/RT. INI1 immunostaining was negative in this case, and a mutation in INI1 was subsequently identified. Immunohistochemical staining with an INI1 antibody correlates with molecular findings in AT/RT and may be useful in confirming the histologic diagnosis. INI1 immunostaining may have particular utility in the analysis of tumors with indeterminate histologic features or atypical immunophenotypic profiles.
Interference between two simple tones.

For various frequencies, 20 subjects adjusted the Δf value of two simple tones after two criteria: (1) maximal roughness and (2) absence of interference and hearing the tones separately. The average results agree rather well with some old data published by Cross and Goodwin (1893) and by Mayer (1894). Over a restricted frequency range, the results obtained for Criterion 2 agree with critical bandwidth.
A comparison of quality satisfaction between transactional and relational customers in e-commerce

Purpose – The purpose of this paper is to examine quality satisfaction between transactional and relational customers in e-commerce, and it also explores the moderating effect of perceived control and perceived enjoyment on quality satisfaction. Design/methodology/approach – Multivariate analysis of variance and two-way ANOVA were conducted to test the study hypotheses. The samples include 470 university students in the northeastern USA to whom an online survey was administered. Findings – Results show that system quality satisfaction is more significant for transactional customers, but information quality and service quality satisfactions are more important for relational customers. Moreover, perceived control and perceived enjoyment partially moderate quality satisfaction between transactional and relational customers. Research limitations/implications – One limitation is that a student cohort is selected as the sample. This study verifies the understanding of quality satisfaction between transactional .
Effects of Saddle Height on Economy and Anaerobic Power in Well-Trained Cyclists

Peveler, WW and Green, JM. Effects of saddle height on economy and anaerobic power in well-trained cyclists. J Strength Cond Res 25(3): 629-633, 2011-In cycling, saddle height adjustment is critical for optimal performance and injury prevention. A 25-35° knee angle is recommended for injury prevention, whereas 109% of inseam, measured from floor to ischium, is recommended for optimal performance. Previous research has demonstrated that these 2 methods produce significantly different saddle heights and may influence cycling performance. This study compared performance between these 2 methods for determining saddle height. Subjects consisted of 11 well-trained (&OV0312;o2max = 61.55 ± 4.72 ml·kg−1·min−1) male cyclists. Subjects completed a total of 8 performance trials consisting of a graded maximal protocol, three 15-minute economy trials, and 4 anaerobic power trials. Dependent measures for economy (&OV0312;o2, heart rate, and rating of perceived exertion) and anaerobic power (peak power and mean power) were compared using repeated measures analysis of variance (α = 0.05). &OV0312;o2 was significantly lower (reflecting greater economy) at a 25° knee angle (44.77 ± 6.40 ml·kg−1·min−1) in comparison to a 35° knee angle (45.22 ± 6.79 ml·kg−1·min−1) and 109% of inseam (45.98 ± 5.33 ml·kg−1·min−1). Peak power at a 25° knee angle (1,041.55 ± 168.72 W) was significantly higher in relation to 109% of inseam (1,002.05 ± 147.65 W). Mean power at a 25° knee angle (672.37 ± 90.21 W) was significantly higher in relation to a 35° knee angle (654.71 ± 80.67 W). Mean power was significantly higher at 109% of inseam (662.86 ± 79.72 W) in relation to a 35° knee angle (654.71 ± 80.67 W). Use of 109% of inseam fell outside the recommended 25-35° range 73% of the time. Use of 25° knee angle appears to provide optimal performance while keeping knee angle within the recommended range for injury prevention.