Miracle-dz/UniFAR-FTUs huggingface dataset:
A Practical Evaluation on RSA and ECC-Based Cipher Suites for IoT High-Security Energy-Efficient Fog and Mist Computing Devices

The latest Internet of Things (IoT) edge-centric architectures allow for unburdening higher layers from part of their computational and data processing requirements. In the specific case of fog computing systems, they reduce greatly the requirements of cloud-centric systems by processing in fog gateways part of the data generated by end devices, thus providing services that were previously offered by a remote cloud. Thanks to recent advances in System-on-Chip (SoC) energy efficiency, it is currently possible to create IoT end devices with enough computational power to process the data generated by their sensors and actuators while providing complex services, which in recent years derived into the development of the mist computing paradigm. To allow mist computing nodes to provide the previously mentioned benefits and guarantee the same level of security as in other architectures, end-to-end standard security mechanisms need to be implemented. In this paper, a high-security energy-efficient fog and mist computing architecture and a testbed are presented and evaluated. The testbed makes use of Transport Layer Security (TLS) 1.2 Elliptic Curve Cryptography (ECC) and Rivest-Shamir-Adleman (RSA) cipher suites (that comply with the yet to come TLS 1.3 standard requirements), which are evaluated and compared in terms of energy consumption and data throughput for a fog gateway and two mist end devices. The obtained results allow a conclusion that ECC outperforms RSA in both energy consumption and data throughput for all the tested security levels. Moreover, the importance of selecting a proper ECC curve is demonstrated, showing that, for the tested devices, some curves present worse energy consumption and data throughput than other curves that provide a higher security level. As a result, this article not only presents a novel mist computing testbed, but also provides guidelines for future researchers to find out efficient and secure implementations for advanced IoT devices.
Characterization of microbes and denitrifiers attached to two species of floating plants in the wetlands of Lake Taihu

Biofilms are often observed at the solid-water interface. The leaves of many floating macrophytes have characteristics of both terrestrial plants and submerged macrophytes, because, in general, their upper and lower surfaces are exposed to air and water, respectively. However, little is known about the biofilms attached to floating plants. We investigated biofilms attached to the leaves, stems and roots of the floating plants Nymphoides peltata (in summer and winter) and Trapa natans (in summer) in the Gonghu Bay of Lake Taihu. Bacteria and algae were major components of the biofilm on the leaves of the two species of plants. In addition, 454 pyrosequencing analysis of bacterial 16S rRNA genes revealed that Proteobacteria was the dominant phylum, followed by Bacteroidetes, Firmicutes, Chloroflexi, Acidobacteria, and Verrucomicrobia. Cluster analysis showed that bacterial communities from the same plant source were clustered into the same group. A total of 677 genera were detected, and 47 genera were shared by all samples. Nitrifiers, including Nitrosomonas, Nitrosococcus and Nitrospira were detected in this study. Seven denitrifying genes (napA, napG, nirS, nirK, cnorB, qnorB and nosZ) were used to detect the abundance of denitrifiers. Genes nirK, nirS cnorB and nosZ were the four most abundant genes in all samples. Our results demonstrated that cultivation of floating plants in water column could enlarge the area for biofilm growth, and biofilms might play an important role in denitrification in eutrophic water.
The influence of knowledge of performance endpoint on pacing strategies, perception of effort, and neural activity during 30‐km cycling time trials

It is understood that withholding information during exercise can alter performance during self‐paced exercise, though less is known about neural activity during such exercise. The aim of this study was to compare the effects of withholding versus providing distance feedback on perception, muscular activation, and cerebral activity during cycling time trials (TT). Nine well‐trained male cyclists randomly completed 2 x 30‐km TT, with provision of performance information and distance feedback (known; KTT), and without performance information and remaining distance (unknown; UTT). Prefrontal cortex (PFC) hemoglobin concentration, electroencephalogy (EEG) responses of the parietal lobe (PL) and motor cortex (MC), and surface electromyogram (EMG) of the right thigh were monitored throughout the TTs, in addition to heart rate (HR), rating of perceived exertion (RPE), and power output (PO). Time to completion was shorter for the KTT compared to UTT (51.04 ± 3.26 vs. 49.25 ± 3.57 min, P = 0.01). There were no differences evident for RPE between conditions (P > 0.50). However, during the final 2 km, the KTT presented higher PO (P ≤ 0.05), HR (P = 0.03) and MC, and PL EEG activity (d = 0.51–0.71) in addition to increased tissue hemoglobin index (nTHI) and oxygen extraction (HHb) (d = 0.55‐0.65) compared to the UTT. In conclusion, when withholding information pertaining to remaining distance, performance was reduced due to the application of a conservative pacing strategy. In addition, the increase in HHb across the PFC was strongly correlated with PO (r = 0.790; P < 0.001) suggesting knowledge about remaining distance may increase activation across the PFC. Further, it appears that changes within the PFC may play a role in the regulation of cycling performance.
Towards An Architecture for Representation, Reasoning and Learning in Human-Robot Collaboration

Robots collaborating with humans need to represent knowledge, reason, and learn, at the sensorimotor level and the cognitive level. This paper summarizes the capabilities of an architecture that combines the comple- mentary strengths of declarative programming, proba- bilistic graphical models, and reinforcement learning, to represent, reason with, and learn from, qualitative and quantitative descriptions of incomplete domain knowledge and uncertainty. Representation and reasoning is based on two tightly-coupled domain representations at different resolutions. For any given task, the coarse- resolution symbolic domain representation is translated to an Answer Set Prolog program, which is solved to provide a tentative plan of abstract actions, and to explain unexpected outcomes. Each abstract action is implemented by translating the relevant subset of the corresponding fine-resolution probabilistic representation to a partially observable Markov decision process (POMDP). Any high probability beliefs, obtained by the execution of actions based on the POMDP policy, update the coarse-resolution representation. When incomplete knowledge of the rules governing the domain dynamics results in plan execution not achieving the desired goal, the coarse-resolution and fine-resolution representations are used to formulate the task of incrementally and interactively discovering these rules as a reinforcement learning problem. These capabilities are illustrated in the context of a mobile robot deployed in an indoor office domain.
Introduction to the Special Issue: Learning to Listen from Sounds to Words

The eight articles in this special issue ‘Learning to listen from sounds to words’ were presented at the conference Sound to Word in Bilingual and Second Language Speech Perception held at the University of Iowa in spring 2016. The selected contributions focus on how second language speech perception interacts with orthography, how phonology interacts with speech perception and how listeners use the cues in the input to segment and create the word forms for lexical processing. This collection of papers expands the field of speech perception and production by granting a central role to the lexicon and exploring how listeners and speakers activate representations, from sounds to words.
Methanolic extract of Tamarix Gallica attenuates hyperhomocysteinemia induced AD-like pathology and cognitive impairments in rats

Although few drugs are available today for the management of Alzheimer’s disease (AD) and many plants and their extracts are extensively employed in animals’ studies and AD patients, yet no drug or plant extract is able to reverse AD symptoms adequately. In the present study, Tamarix gallica (TG), a naturally occurring plant known for its strong antioxidative, anti-inflammatory and anti-amyloidogenic properties, was evaluated on homocysteine (Hcy) induced AD-like pathology and cognitive impairments in rats. We found that TG attenuated Hcy-induced oxidative stress and memory deficits. TG also improved neurodegeneration and neuroinflammation by upregulating synaptic proteins such as PSD95 and synapsin 1 and downregulating inflammatory markers including CD68 and GFAP with concomitant decrease in proinflammatory mediators interlukin-1β (IL1β) and tumor necrosis factor α (TNFα). TG attenuated tau hyperphosphorylation at multiple AD-related sites through decreasing some kinases and increasing phosphatase activities. Moreover, TG rescued amyloid-β (Aβ) pathology through downregulating BACE1. Our data for the first time provide evidence that TG attenuates Hcy-induced AD-like pathological changes and cognitive impairments, making TG a promising candidate for the treatment of AD-associated pathological changes.
The Two-Faced Cytokine IL-6 in Host Defense and Diseases

Interleukein-6 (IL-6), is produced locally from infectious or injured lesions and is delivered to the whole body via the blood stream, promptly activating the host defense system to perform diverse functions. However, excessive or sustained production of IL-6 is involved in various diseases. In diseases, the IL-6 inhibitory strategy begins with the development of the anti-IL-6 receptor antibody, tocilizumab (TCZ). This antibody has shown remarkable effects on Castleman disease, rheumatoid arthritis and juvenile idiopathic arthritis. In 2017, TCZ was proven to work effectively against giant cell arteritis, Takayasu arteritis and cytokine releasing syndrome, initiating a new era for the treatment of these diseases. In this study, the defensive functions of IL-6 and various pathological conditions are compared. Further, the diseases of which TCZ has been approved for treatment are summarized, the updated results of increasing off-label use of TCZ for various diseases are reviewed and the conditions for which IL-6 inhibition might have a beneficial role are discussed. Given the involvement of IL-6 in many pathologies, the diseases that can be improved by IL-6 inhibition will expand. However, the important role of IL-6 in host defense should always be kept in mind in clinical practice.
Cognitive Assistance to Meal Preparation: Design, Implementation, and Assessment in a Living Lab

This paper first sketches a living lab infrastructure installed in an alternative housing unit built to host 10 people with traumatic brain injury. It then presents the first research project in progress within this living lab. This interdisciplinary project aims at designing, implementing, deploying, and assessing a personalized assistive technology (PAT). Based on the needs and expectations expressed by the residents, their caregivers and their families, a cooking assistant appeared as one of the best suited PAT to foster residents autonomy and social participation. The resulting PAT will rely on pervasive computing and ambient intelligence. It will then be personalized according to each participant's capacities and specific cognitive impairments. The impact of the assistant on autonomy and quality of life will then be measured. The overall organizational impact of such assistive technology will be also documented and evaluated.
Holobiont suture zones: Parasite evidence across the European house mouse hybrid zone

Parasite hybrid zones resulting from host secondary contact have never been described in nature although parasite hybridization is well known and secondary contact should affect them similarly to free‐living organisms. When host populations are isolated, diverge and recontact, intimate parasites (host specific, direct life cycle) carried during isolation will also meet and so may form parasite hybrid zones. If so, we hypothesize these should be narrower than the host’s hybrid zone as shorter parasite generation time allows potentially higher divergence. We investigate multilocus genetics of two parasites across the European house mouse hybrid zone. We find each host taxon harbours its own parasite taxa. These also hybridize: Parasite hybrid zones are significantly narrower than the host’s. Here, we show a host hybrid zone is a suture zone for a subset of its parasite community and highlight the potential of such systems as windows on the evolutionary processes of host–parasite interactions and recombinant pathogen emergence.
The Dilemma of Cure and Damage in Oligodendroglioma: Ways to Tip the Balance Away from the Damage

Current treatments for oligodendrogliomas are powerful but have a negative impact on the rest of the body. The bone marrow is damaged by the chemotherapeutics, but other parts of the body are also affected. In this paper, the current treatment method and its collateral damage is described. Therefore, therapies are needed that are more effective against the tumor while having less negative effects on the patient’s quality of life. Some potential therapies include optimal removal of the tumor by fluorescent-guided surgery (FGS), intraoperative desorption electrospray ionization-mass spectrometry (DESI-MS), better monitoring of the effects of therapy by pseudo-coloring shades of gray of MRI pictures, and using recent data from RNA sequencing of single cells and immunotherapy. These are all open new ways of treating this tumor. The RNA sequencing of single tumor cells unravels specific tumor antigens present in the differentiation status of the cancer cell. Stem cell antigens were expressed in dividing cells, while hypoxia inducible factor-α (HIF-1α) is expressed in all tumor cells. Cancer stem cell antigens can be loaded on dendritic cells to induce cytotoxic T-cells directed to cancer stem cells. These recent discoveries suggest a better quality of life with the same overall survival.
High prevalence of carriage of mcr-1-positive enteric bacteria among healthy children from rural communities in the Chaco region, Bolivia, September to October 2016

Background The mcr-1 gene is a transferable resistance determinant against colistin, a last-resort antimicrobial for infections caused by multi-resistant Gram-negatives. Aim To study carriage of antibiotic-resistant bacteria in healthy school children as part of a helminth control and antimicrobial resistance survey in the Bolivian Chaco region. Methods From September to October 2016 we collected faecal samples from healthy children in eight rural villages. Samples were screened for mcr-1- and mcr-2 genes. Antimicrobial susceptibility testing was performed, and a subset of 18 isolates representative of individuals from different villages was analysed by whole genome sequencing (WGS). Results We included 337 children (mean age: 9.2 years, range: 7–11; 53% females). The proportion of mcr-1 carriers was high (38.3%) and present in all villages; only four children had previous antibiotic exposure. One or more mcr-1-positive isolates were recovered from 129 positive samples, yielding a total of 173 isolates (171 Escherichia coli, 1 Citrobacter europaeus, 1 Enterobacter hormaechei). No mcr-2 was detected. Co-resistance to other antimicrobials varied in mcr-positive E. coli. All 171 isolates were susceptible to carbapenems and tigecycline; 41 (24.0%) were extended-spectrum β-lactamase producers and most of them (37/41) carried bla CTX-M-type genes. WGS revealed heterogeneity of clonal lineages and mcr-genetic supports. Conclusion This high prevalence of mcr-1-like carriage, in absence of professional exposure, is unexpected. Its extent at the national level should be investigated with priority. Possible causes should be studied; they may include unrestricted use of colistin in veterinary medicine and animal breeding, and importation of mcr-1-positive bacteria via food and animals.
Reduction of the State Observation Problem to an Identifiability Problem

Data integrity is a property which a world state interpreted with a world model is consistent with the real operating environment. Even a formally veriﬁed safety claim of an autonomous system is prone to a malfunction caused by loss of data integrity. From a ﬁrst-person viewpoint in a congested environment, some components of measurable part of the world state may become transiently deﬁcient or unavailable because of the limited capability of sensor devices. If the system could get into a situation where the world state becomes suddenly unobservable, existing estimation methods may get unstable. These methods can hardly detect the loss of data integrity and produce an incorrect estimate without any notice. Our insight is that we can merge the original concept of observer theory with that of automated reasoning. Firstly, we propose a new way of unifying them into a problem of checking satisﬁability of a formula that consists of predicates regarding the world model and decision variables regarding unmeasurable part of the world state. We can detect a loss of data integrity by checking if the problem is unsatisﬁable. Secondly, we replace the idea of observability in control theory with identiﬁability with respect to a measure of tolerance and a world model. We show a procedure of estimating the world state with a bounded uncertainty speciﬁed by the measure of tolerance. Third, we show that a problem of sensor fusion, a problem of reasoning a world state of discrete and enumerated type, and a decision problem under uncertainty in the world state are formulated as an identiﬁability problem. The proposal presents a constructive basis for supporting the degree of conﬁdence in the estimated world state.
Dynamic thiol/disulphide homeostasis in vitiligo patients

Introduction Vitiligo is an acquired depigmentation disorder with melanocyte destruction. Aim To examine the thiol/disulphide balance in vitiligo patients and to compare the results with a healthy control group. Material and methods Thirty-two patients with vitiligo and 35 healthy individuals were included in the study. Native thiol, disulfide and total thiol levels in plasma were evaluated using a new and automated spectrophotometric method. Disulphide/total thiol, disulphide/native thiol and native thiol/total thiol levels were measured. Results There was no statistically significant difference between the two groups when the patient and control groups were compared in terms of thiol/disulphide balance (p > 0.05). There was no statistically significant difference in native thiol, disulphide and total thiol levels for vitiligo when compared with the control group (p > 0.005). Conclusions In recent years, there have been numerous studies on the role of oxidative stress in the etiopathogenesis of vitiligo. In this study, we investigated in vitiligo patients whether thiol/disulphide balance is a new oxidative stress marker. The results were compared with a healthy control group. We measured the thiol/disulphide balance by a new method developed by Erel and Neselioglu. The serum thiol/disulphide levels were similar in the vitiligo patients and the control subjects, which indicated that the thiol/disulphide balance was not affected by vitiligo. We are of the opinion that new investigations to determine serum levels of thiol/disulphide may shed light on the possible roles of these molecules in vitiligo.
Long noncoding RNA uc.4 inhibits cell differentiation in heart development by altering DNA methylation

In previous studies, we have demonstrated that long noncoding RNA uc.4 may influence the cell differentiation through the TGF‐β signaling pathway, suppressed the heart development of zebrafish and resulting cardiac malformation. DNA methylation plays a significant role in the heart development and disordered of DNA methylation may cause disruption of control of gene promoter. In this study, methylated DNA immunoprecipitation was performed to identify the different expression levels of methylation regions. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were also performed to identify the possible biological process and pathway that uc.4 may join, associated with Rap1 signaling pathway, gonadotropin‐releasing hormone signaling pathway, and Calcium signaling pathway. We found that the distribution of differentially methylated regions peaks was mainly located in intergenic and intron regions. Altogether, our result showed that differentially methylated genes are significantly expressed in uc.4‐overexpression cells, providing valuable data for further exploration of the role of uc.4 in heart development.
A note on a naive regression‐based test on the validity of an instrumental variable

Instrumental variable (IV) methods have been commonly used to address the bias from unmeasured confounding in observational studies. As depicted in Figure 1, a valid IV needs to satisfy three assumptions1,2: (i) IV has a nonzero effect on treatment, (ii) IV is independent of unmeasured confounders, and (iii) IV cannot have a direct effect on outcome and all of its effects on outcome has to go through treatment. This assumption is also known as exclusion restriction. That is, IV is excluded from any causal relationship with the outcome. The regression of the outcome on a treatment variable and IV along with observed confounders is often considered by some researchers to examine the validity of IV,1 even in prominent medical journals.3 The thinking behind this approach is that, since treatment completely mediates the path from IV to the outcome and IV has no direct and other indirect relationships with the outcome under the assumptions (ii) and (iii), the coefficient of IV is zero after controlling the treatment in the regression model. However, this approach is not a valid test because the coefficient is typically nonzero even if the IV assumptions hold.1 Baiocchi et al1 gave a proof in the context of the principal stratification framework and under the heterogeneous treatment effect. In this note, we present another explanation under the regression model framework and the homogeneous or constant treatment effect. For this purpose, we derive a closed-form expression of the regression coefficients through the least squares projections and show that the coefficient for IV is nonzero in typical scenarios.
canSAR: updated cancer research and drug discovery knowledgebase

canSAR (http://cansar.icr.ac.uk) is a public integrative cancer-focused knowledgebase for the support of cancer translational research and drug discovery. Through the integration of biological, pharmacological, chemical, structural biology and protein network data, it provides a single information portal to answer complex multidisciplinary questions including—among many others—what is known about a protein, in which cancers is it expressed or mutated, and what chemical tools and cell line models can be used to experimentally probe its activity? What is known about a drug, its cellular sensitivity profile and what proteins is it known to bind that may explain unusual bioactivity? Here we describe major enhancements to canSAR including new data, improved search and browsing capabilities and new target, cancer cell line, protein family and 3D structure summaries and tools.