Miracle-dz/UniFAR-FTUs huggingface dataset:
The productivity improvement effect of surrounding firms in the Japanese manufacturing industry ― industrial agglomeration and international trade ―

This paper aims to show that the productivity improvement effect of industrial agglomeration in the manufacturing industry in Japan is decreasing, while industrial infrastructure is maintained and international trade continues to advance. Industrial mesh data from 1990 to 2010 were used for the analysis. Because mesh data were used, it was possible to analyze the data by latitude and longitude. We found that the productivity improvement effect of industrial agglomeration was not clear in every case during the period studied and the effect of the agglomeration of firms was found to be decreasing in the manufacturing industry year by year. It is thought that increases in importing and exporting that result from the formation of the global value chain have influenced the gradual decrease in the effect of agglomeration. This decreasing productivity improvement effect associated with industrial agglomeration affects the creation of industrial clusters in Japan. 要旨:産業インフラが整備され,産業の国際分業が進む中で,製造業事業所が集積することによる生 産性向上効果を分析した。 分析には1990年から2010年までの工業メッシュデータを用いた。 メッシュ ごとのデータを用いたので市区町村の行政単位の再編の問題を避け,緯度経度での区割りで分析を行 うことができた。 その結果,製造業においては事業所が集中することの効果は明確ではなく,周辺事 業所の生産性に対する効果は年々減少していることが明らかとなった。 周辺事業所効果の減少には, 国際分業による輸出入の増加が影響していると考えられる。
Role of Her-2 Neu As Prognostic Indicator in Surface Epithelial Tumors of Ovary

Introduction : Ovarian cancer is major cause of mortality in women . Now a days so many biomarkers like P53,EGFR, Ki67,CK are used for early detection to predict the prognosis and planning for better treatment. Aims Of Study : To know the role of HER-2/neu expression in surface epithelial tumors of ovary in assessing the prognosis and to know its relation with age of patient, tumor size and grade of tumor. Materials & Methods : Present study conducted for a period of 2 yrs (July 2012 to June 2014) in Government General Hospital, Rangaraya Medical College,Kakinada. During this period we selected total 50 cases of surface epithelial tumors in that we did immunohistochemistry (IHC) with HER 2 neu marker for 32 cases. Conclusion : HER 2 neu expression is not significantly associated with grade of the tumor, type of tumor and age of the patient, but expression somewhat significantly observed in large tumor size (> 10 cm dia).
A 1.6GHz 16×16-bit low-latency pipelined booth multiplier

This paper presents a high-speed 16×16-bit CMOS pipelined booth multiplier. By using new partial product generation and booth encoder circuits and a novel adder, speed of pipelined multipliers is improved. By these new architectures, final adder performs 25 bit addition in only two cycles with high speed (1.6 GHz). Due to lower number of cycles (5 clock cycles), delay of the overall circuit is only 3.1ns and besides power consumption is decreased so that at a data rate of 1 GHz and under the supply voltage of 3.3V, power consumption is 176mW. This multiplier is implemented in TSMC 0. 35μm CMOS technology.
Increased T-Cell Sinusoidal Lymphocytosis in Liver Biopsies in Patients With Chronic Hepatitis C and Mixed Cryoglobulinemia

Mixed cryoglobulinemia (MC) has a strong association with hepatitis C virus (HCV) infection and is associated with a higher degree of fibrosis and poor response to therapy. Currently, there are no known histological findings on liver biopsy that correlate with the presence of MC in HCV-infected patients, although we have occasionally noted prominent sinusoidal lymphocytosis in MC patients. The goal of this study is to determine whether sinusoidal lymphocytosis is a histological marker of MC in liver biopsies from patients with chronic hepatitis C. The liver clinic database at our institution was searched for chronic hepatitis C patients with MC who underwent liver biopsy during 1999–2005. Ten such cases were identified and were included in the study. Ten chronic hepatitis C MC-negative cases were matched for age and stage of fibrosis to serve as controls. Histological features (sinusoidal lymphocytes, inflammatory activity, acidophil bodies, and fibrosis stage) were evaluated in each biopsy. Clinical and laboratory data (serum protein electrophoresis, liver enzymes, hepatitis C viral load, treatment status, comorbidities, etc.) were also recorded. Formalin-fixed, paraffin-embedded sections were submitted for immunohistochemical analysis using antibodies against CD3, CD20, CD4, CD8, and CD68. Sinusoidal lymphocytes were counted in 5 hpf (40×) on hematoxylin and eosin (H&E) stain, and on CD3 and CD20 immunostains. The number of CD68+ Kupffer cells was also counted in a similar fashion. In the MC-positive versus MC-negative cases, mean fibrosis stage (2.4 vs. 2.4), inflammatory grade (1.7 vs. 2.1), lymphocyte count (359 vs. 128/5 hpf), and Kupffer cell count (239 vs. 220/5 HPF) were assessed. There was a significant increase in sinusoidal T-cell lymphocytes (P < 0.05) in MC-positive cases as compared to MC-negative cases. Nearly all sinusoidal lymphocytes were CD8-positive cells in both groups. Other histological parameters did not differ in the two groups. MC-positive cases tended to have a lower viral load as compared to controls (P = 0.059). The role of sinusoidal T cells in the pathogenesis of MC is currently unknown. It is unclear if the presence of these cells implies ongoing antigenic stimulation that may lead to increased risk of lymphoma. This feature may be an important clue to predict the presence of MC, an HCV-associated phenomenon that has important implications for response to treatment and disease progression.
Quantitative indicators for social sustainability assessment of society and product responsibility aspects in supply chains

Increased pressures from stakeholders have been forcing companies to integrate social sustainability into their businesses. However, lack of information leads to gaps in social sustainability, some of them being also related to difficulties in social sustainability assessment of supply chains often caused by lack of appropriate quantitative indicators to be used. The aim of this paper is, thus, to fill this gap by proposing a set of quantitative social sustainability indicators applicable to various types of supply chains. The indicators proposed here address the most frequently encountered issues of social sustainability. The research resulted in the identification of 24 generic quantitative indicators suitable for the assessment of a supply chain, particularly related to society and product Received: August, 2017 1st Revision: September, 2017 Accepted: November, 2017 DOI: 10.14254/20718330.2017/10-4/1 Journal of International Studies S ci en ti fi c P a pe rs © Foundation of International Studies, 2017 © CSR, 2017 Journal of International Studies Vol.10, No.4, 2017 10 responsibility issues. The indicators are validated through content analysis of 141 sustainability reports from all echelons (upstream, midstream, downstream) of a supply chain. Beyond that, one-way statistical analysis (ANOVA) is performed in order to analyse how echelon levels affect the relevance of these indicators. Content analysis results confirm that issues covered by the indicators are addressed by the companies in their sustainability reports, while ANOVA analysis shows that supply chain echelon level does not influence the relevance of the indicators, making this set of indicators generic and applicable to any supply chain. Therefore, these indicators can be considered as generic and used for the holistic assessment of supply chains.
Rescue the Competitor: Acceptance of Sports Clubs' Expenditures to Avoid a Sports Club's Closure

Faced with an increasingly challenging environment, including cutbacks in subsidies as well as growing competition for customers and resources, nonprofit sports clubs are seeking ways to survive, to remain viable, and to grow. As early as in 1998, Weisbrod brought up the subject that “competition, the pursuit of the same objective by two or more firms, creates rivalry among nonprofits for capital, labor, customers, and/or revenues. ” In line with this idea, professional management has received growing attention in organizations operating in a competitive environment. In contrast to the view of nonprofit sports clubs as harsh competitors, the importance of collaborations has also been stressed. There is empirical evidence that organizations, in particular nonprofit sports clubs, which act in the same sector and pursue the same mission, collaborate and have an interest that their competitor survives (e.g., to secure league operations). Therefore it might seem reasonable for them to rescue their competitor. However, rescuing another organization might counteract the interests of an organization’s members, especially if the main (sport) competitor is saved. Against this backdrop, this paper seeks to explore the following research question:
Preliminary biochemical characterization of faeces from uninfected rats and rats infected with the tapeworm, Hymenolepis diminuta

Abstract Faecal pellets were collected from uninfected rats and rats infected with Hymenolepis diminuta, and analysed for caloric value, lipids, carbohydrates, glucose, amino acids, and proteins. Faeces from infected rats contained significantly more lipid and less carbohydrate and glucose than faeces from control rats. The total free amino acid content of faeces from infected and control rats did not differ, but there were significant differences in the amounts of individual free amino acids. The data support the hypothesis that the nutrient composition of faeces from infected and control hosts differ. Beetles that serve as the intermediate host for H. diminuta may be able to detect these differences, and this may explain why beetles preferentially ingest faeces containing the tapeworm's eggs.
Cruciate Retaining compared with Posterior Stabilised Nexgen total knee arthroplasty: results at 10 years in a matched cohort

INTRODUCTION Debate has persisted for many years about whether to sacrifice or replace the posterior cruciate ligament when performing total knee arthroplasty. A paucity of long‐term follow‐up studies comparing outcomes between cruciate‐retaining and posterior‐stabilised knees exist. We aimed to compare results at ten‐year follow‐up. METHODS A matched paired study comparing a cohort of 107 Zimmer Nexgen® Cruciate Retaining (CR) patients with a cohort of 107 Nexgen Posterior‐Stabilised (PS) knees matched for age, sex, body mass index and preoperative American Knee Society score was undertaken. All patients underwent independent clinical assessment and knee society scoring preoperatively and at 1, 3, 5, 7 and 10 years postoperatively. RESULTS Fifty‐three patients (49.5%) in the CR group and 44 patients (41.1%) in the PS group were alive at 10‐year follow‐up. There were no significant differences between the CR and PS groups with regards to functional assessment (P = 0.95), overall range of movement (P = 0.46) or patient satisfaction (P = 1.0) at 10 years. However, there was a significantly better score improvement in range of movement in PS knees compared with CR knees (P = 0.027). There were six revisions (5.6%) in the PS group and 1 (0.93%) in the CR group (P = 0.12). Both CR and PS knees showed excellent survivorship with no significant difference at 10 years (P = 0.068). CONCLUSIONS There were no significant differences in functional score, overall range of motion or patient satisfaction between the Nexgen cruciate retaining and posterior stabilised total knee arthroplasty at 10‐year follow‐up. However, PS knees had a greater score improvement in range of motion compared with CR knees.
Issues of care for hospitalized youth.

Knowledge of normal adolescent development and which issues most impact morbidity and mortality in this age group are critical when planning health care delivery for youth in the hospital setting. Comprehensive health care also requires a clear understanding of the legal and ethical issues that affect the adolescent population. This statement reviews the concepts of providing developmentally appropriate care for youth when they are admitted into a hospital setting. In accordance with the World Health Organization and the Canadian Paediatric Society, an adolescent is roughly defined as an individual between 10 and 19 years of age [1].
The Alternative Sigma Factor SigH Regulates Major Components of Oxidative and Heat Stress Responses in Mycobacterium tuberculosis

ABSTRACT Mycobacterium tuberculosis is a specialized intracellular pathogen that must regulate gene expression to overcome stresses produced by host defenses during infection. SigH is an alternative sigma factor that we have previously shown plays a role in the response to stress of the saprophyte Mycobacterium smegmatis. In this work we investigated the role ofsigH in the M.tuberculosis response to heat and oxidative stress. We determined that a M. tuberculosis sigHmutant is more susceptible to oxidative stresses and that the inducible expression of the thioredoxin reductase/thioredoxin genestrxB2/trxC and a gene of unknown function, Rv2466c, is regulated by sigH via expression from promoters directly recognized by SigH. We also determined that thesigH mutant is more susceptible to heat stress and that inducible expression of the heat shock genes dnaK andclpB is positively regulated by sigH. The induction of these heat shock gene promoters but not of other SigH-dependent promoters was markedly greater in response to heat versus oxidative stress, consistent with their additional regulation by a heat-labile repressor. To further understand the role ofsigH in the M.tuberculosis stress response, we investigated the regulation of the stress-responsive sigma factor genessigE and sigB. We determined that inducible expression of sigE is regulated bysigH and that basal and inducible expression ofsigB is dependent on sigE andsigH. These data indicate that sigH plays a central role in a network that regulates heat and oxidative-stress responses that are likely to be important in M.tuberculosis pathogenesis.
β2‐adrenergic receptors expressed on murine chondrocytes stimulate cellular growth and inhibit the expression of Indian hedgehog and collagen type X

The sympathetic nervous system has been demonstrated to have a role in regulating bone remodeling through β‐adrenergic receptors (β‐AR) expressed on osteoblasts. Studies using β2‐adrenergic receptor agonists in vivo have also suggested an effect on endochondral bone development; however, it was not clear if this effect was mediated through osteoblasts or chondrocytes. To more thoroughly examine the role of β‐AR in chondrocytes we characterized the expression and signal transduction systems activated by β‐AR in growth plate chondrocytes prepared from ribs of embryonic E18.5 mice. Using RT‐PCR and immunohistochemistry we found that the chondrocytes expressed only β2‐AR. The receptors were coupled to stimulation of adenylyl cyclase, phosphorylation of the cyclic AMP response element binding protein (CREB) and extracellular signal‐regulated kinase (ERK1/2). Stimulation of ERK1/2 was transient and limited by the concomitant stimulation of the mitogen‐activated protein kinase phosphatase (MKP‐1). Isoproterenol stimulated the growth of chondrocytes as assessed by increased incorporation of [3H]‐thymidine into the cells. The cellular expression of two markers of chondrocyte differentiation, Indian hedgehog, expressed in pre‐hypertrophic cells and collagen type X, expressed in hypertrophic chondrocytes, were both significantly inhibited after incubation with isoproterenol. Collectively, these findings demonstrate regulation of chondrocytes through β2‐AR expressed on the cells that stimulate their growth and inhibit their differentiation, indicating that the sympathetic nervous system may be an important regulator of embryonic cartilage development. J. Cell. Biochem. 104: 545–553, 2008. © 2007 Wiley‐Liss, Inc.
Detection of Insufficient Effort Using the Advanced Clinical Solutions for the Wechsler Memory Scale, Fourth Edition

This study investigated the ability of the Wechsler Memory Scale-4th Edition (WMS-IV) and the Advanced Clinical Solutions (ACS) package including the new Word Choice test (WCT) to distinguish poor performance due to intentional response bias among simulators of traumatic brain injury (TBI) from poor performance due to actual TBI. Participants were 45 survivors of moderate to severe TBI and 39 healthy adult coached to simulate TBI. Logistic regression indicated that a five-variable model containing all the ACS variables and a single-variable model using only the WCT were statistically reliable. Comparing predictive accuracy of each model found that adding the WCT to the ACS increased predictive accuracy. Diagnostic efficiency for the full ACS model was considered “excellent” according to interpretive guidelines.
Design and implementation of one redundancy function in wireless tree networks

Communication reliability has always been the bottleneck problem for wireless networks. Combining with the development of wireless networks for emergency application, a new approach is proposed to implement the redundancy function in wireless tree network. The necessity of this approach is analyzed, the whole system includes software and hardware is designed, the significative experiment is completed that shows this approach effectively ensures the communication reliability of wireless tree network and the whole network possesses the functions of redundancy and self-healing.
Vision-based autonomous hovering for a miniature quad-rotor

SUMMARY In this paper, a vision-based scheme for the autonomous hovering of a miniature quad-rotor is developed. Cameras are used to estimate the position and the translational velocity of the vehicle. The dynamic model of the miniature quad-rotor is developed using the Newton–Euler approach. A nonlinear controller based on a separated saturation control strategy for a miniature quad-rotor is presented. To validate the theoretical results, an embedded control system for the miniature quad-rotor has been developed. Thus, the analytic results are supported by experimental tests. Experimental results have validated the proposed control strategy.
MORTGAGE LOANS AND FINANCIAL SECURITY AMONG MIDDLE-AGED AND OLDER AMERICANS

OF DISSERTATION MORTGAGE LOANSAND FINANCIAL SECURITYAMONG MIDDLE-AGEDAND OLDERAMERICANS Mortgage loan debt is prevalent among middle-aged and older Americans. With higher average outstanding balances, many people are unlikely to pay off their mortgage debt by retirement. Meanwhile, as people age, health shocks are more likely to occur. Medical expensesmay competewithmortgage payments and relate to financial insecurity in later years. In order to alleviate financial strain during times of financial hardship, senior homeowners may find reverse mortgage the solution they are looking for. TargetingAmerican adults age 50 and older, this dissertation investigates mortgage loan debt and financial security using panel data from the Health and Retirement Study. Chapter 1 provides an overview of this dissertation and three studies. Chapter 2 investigates whether retirement preparedness plays a role in mortgage status at retirement, shown here as whether a person has mortgage debt and how much the remaining balance is (Waves 2004-2014). Chapter 3 examines health impact on likelihood of paying off mortgage loans under different health conditions, with estimates on expected time to mortgage payoff (Waves 2004-2014). Chapter 4 focuses on reverse mortgages and their impact on senior borrowers’ financial satisfaction and liquidity constraint (Waves 2010-2016). Chapter 5 summarizes major findings in three studies and highlights the contribution of this dissertation toward middle-aged and older Americans’ financial security. Limitations of three studies are discussed in Chapter 6. Three studies provide evidence on 1) the importance of preparedness on reduced mortgage burden; 2) adverse impact of health shock on likelihood of mortgage payoff; and 3) using reverse mortgages to reduce financial strain and increase financial satisfaction. Implications are addressed in each study.
Études préliminaires de sûreté du réacteur à sels fondus MSFR.

Les reacteurs nucleaires de 4eme generation devront permettre une utilisation optimisee desressources naturelles. Les travaux realises durant cette these se placent ainsi dans le cadre del’etude du potentiel de deploiement d’un tel reacteur : le MSFR (Molten Salt Fast Reactor), reacteura sels fondus a spectre neutronique rapide dans une configuration innovante et encore peuetudiee. Comme un excellent niveau de surete est une condition necessaire pour le deploiementde l’energie nucleaire, il est important de soulever la question de la surete de ce type de reacteurdes les premieres phases de sa conception.Le MSFR a fait l’objet d’etudes comparatives des outils de simulations numeriques dans lecadre d’un benchmark neutronique au sein du projet europeen EVOL. La definition et l’analysedu benchmark neutronique statique et en evolution ont ete realisees pendant cette these. Lescomparaisons des differentes grandeurs physiques ont permis de conclure a un bon accord entreles differents codes et methodes utilises par les partenaires du projet, et ont mis en avant l’influencedu choix des bases de donnees nucleaires. Dans l’objectif de l’etude de surete du MSFR,la puissance residuelle a aussi ete etudiee en details. Un outil de calcul de chaleur residuellea ete developpe et valide, permettant ainsi d’evaluer la puissance residuelle precise du MSFR.Les sources de chaleur de chaque localisation contenant des produits radioactifs ont alors etequantifiees. Ceci a permis de conclure que le sel combustible et l’unite de bullage constituent lessources majeures de puissance residuelle.Nous avons initie un travail sur la methodologie de l’etude de surete. Les principes fondamentauxde surete sont directement transposables au MSFR, mais leurs applications concretes nele sont pas. En effet, la specificite du design, due a l’etat liquide du combustible et aux systemesde retraitement associes au reacteur, ainsi que l’etat embryonnaire du design, font qu’un travailpreliminaire de transposition des elements de surete a du etre realise. Ce travail a conduit entreautres a dresser une liste d’accidents propres au MSFR. Enfin, nous avons pu mener des etudesphysiques preliminaires sur les consequences possibles de certains de ces accidents, qui serontutilisees comme base pour des etudes plus approfondies avec des outils plus sophistiques.
Buspirone in the Treatment of Posttraumatic Stress Disorder

Three patients with a DSM‐III‐R diagnosis of posttraumatic stress disorder were successfully treated with buspirone in final maximum dosages ranging from 35–60 mg daily. The onset of clinical efficacy ranged from 5–29 days. Symptoms that improved included anxiety, insomnia, flashbacks, and depressed mood. Patients experienced no side effects. Serotonin partial agonist effects are a possible mechanism underlying buspirone's efficacy.