Miracle-dz/UniFAR-FTUs huggingface dataset:
Heterogeneous nuclear ribonucleoproteins (hnRNPs) and human transformer-2-beta1 (hTra2-beta1)-regulated estrogen receptor-alpha improves prognosis of endometrial cancer.

PURPOSE OF INVESTIGATION Heterogeneous nuclear ribonucleoprotein (hnRNP) family possesses decreasing effect towards endometrial cancer (EC) and human transformer-2-betal (hTra2-betal) performs an intimate relationship with EC, either. Recent study shows that hnRNPs and hTra2-betal regulate the genetic expression, which is concerned with estrogen receptor (ER). MATERIALS AND METHODS The present study was designed to investigate the link between ER and hnRNPs or hTra2-betal in the prognosis of EC patients by Real-time PCR and immunohistochemisty (IHC). RESULTS Results showed that ER protein expression presented a significant change in the recurrence and outcome of EC patients, and the nucleus hTra2-betal protein expression was also increased in the recurrent patients, indicating that the three might be important in ER expression in the prognosis therapy of EC patients. CONCLUSION The present findings provide an insight of pharmaceutical targeting therapy and prognosis of EC.
Gastrointestinal stromal tumor of the pancreas: A case report and review of the literature

Context: Primary stromal tumors of the pancreas are extremely rare. Only four cases have been reported in the literature. We describe a new case and analyze, through a review of the literature, the clinical and pathological data, and the outcome of the previously reported cases. Case report: We report the case of a 52-year-old-woman who presented with epigastric pain. Preoperatively, abdominal pelvic computed tomography revealed a pancreatic head mass. The surgery confirmed the presence of a large tumor of the pancreatic head. Pathologic results revealed a malignant gastrointestinal stromal tumor of the pancreatic head, completely removed. There is no recurrence or metastases 10 months after surgery. Conclusion: The current case consolidates the possibility that this rare tumor can involve the pancreas as a primary site and that GIST of primary pancreatic localization are usually of high risk of malignancy.
Production of lesions in gnotobiotic mice by inoculation with Treponema hyodysenteriae

Treponema hyodysenteriae was established in the ceca of gnotobiotic mice in the absence of other organisms. Superficial mucosal lesions characteristic of swine dysentery were present in the ceca of mice inoculated with T. hyodysenteriae in combination with viable Bacteroides vulgatus. Deep crypt necrosis was detected in the ceca of mice inoculated with T. hyodysenteriae alone.
Have expert guidelines made a difference in asthma outcomes?

Purpose of reviewTo analyze and summarize research from 2011 to 2012 that examines the relationship of guideline implementation and asthma outcomes. Recent findingsEvidence of an unmet need for better asthma management was reported in two large survey studies from the US and Europe. Interventional studies of guideline implementation were often limited by lack of uptake of the intervention (i.e. educational program, computer-assisted assessment). Even studies in which there was uptake to the intervention, asthma outcomes often did not improve. Certain interventions (specific electronic asthma management tools, provider education workshops, community-wide interventional programs, and parental educational programs) were associated with improved asthma outcomes. Observational studies, likewise, revealed that evidence of guideline implementation did not necessarily translate into improved asthma outcomes. SummaryAsthma guideline implementation studies are frequently associated with a limited impact on asthma outcomes. Understanding the gaps between guideline recommendations and translation to clinical practice remains an important opportunity to improve asthma outcomes.
10-Formyltetrahydrofolate synthetase activity in normal and brugia pahangi-infected Aedes aegypti.

The activity of 10-formyltetrahydrofolate synthetase (f1oFHS) in crude extracts of 4- to 5-day-old adult male and uninfected female Aedes aegypti was higher than that of other folate-related enzymes studied so far. L-Cysteine, Mg2? , and NH4? were required for optimal activity of this enzyme in the forward direction (forming f1oFH4, ADP and P1). The apparent Km values of the substrates and cofactors for the forward reaction showed correspondence between ATP and Mg2' (both 0.07 mM) and formate and NH? (13 mM and 7 mM); the apparent Km value of FH, (0.26 mM) corresponded closely to the Ki value of the 4-amino analog of folate methotrexate (0.24 mM), the latter being a competitive inhibitor of the enzyme. The estimated molecular weight of A. aegypti PfoFHS was 260,000. Two compounds were relatively strong inhibitors of the enzyme, as indicated by their IDo50 value: metho- trexate (2 CM) and suramin (8 /tM). The activity of PoFHS was approximately 40% lower in unin- fected female mosquitoes more than a week old than in those only 5 days old. The activity of this enzyme in female mosquitoes 7 days after they fed upon Brugia pahangi-infected jirds was approximately the same as that in age-matched uninfected females. However, the activity of fpoFHS in female mos- quitoes 12 days after infection with B. pahangi was 50% lower than that in age-matched uninfected fe- males. The significance of this latter finding is discussed.
Mycobacterial protein antigens: a compilation

In response to recommendations from the Steering Committees responsible for co‐ordination of World Health Organization programmes for research on the immunology of leprosy (IMMLEP) and tuberculosis (IMMTUB), a list was prepared summarizing the properties of mycobacterial proteins currently under investigation with respect to their immunological activities. After consultation with more than 40 laboratories world‐wide this list was extended to form the compilation shown below and is intended to provide a comprehensive and convenient reference for future studies in this field.
A normalized residual energy clustering for wireless sensor networks

This paper contributes to recent improvements in energy-efficient clustering algorithms for static and homogeneous wireless sensor networks. We propose a modified algorithm, called NREC, which considers information on the locally normalized residual energy of sensor nodes. This information is weighted with the probabilistic threshold used in standard algorithms for periodic election of cluster heads. The performance of our solution is compared with that of previously proposed variants by detailed simulation. Reduction of energy consumed per bit of useful data is shown.
Preparation and medical follow-up for a single-handed transatlantic rowing race.

BACKGROUND A single-handed transatlantic rowing race was organised between Senegal and French Guyana (2600 nautical miles). During the race, rowers adjust their lifestyle to maintain an optimal level of performance. Nutrition, circadian rhythm disturbance, psychological state, pain and other medical problems impact on physical abilities and increase the occurrence of accidents. We surveyed the prevalence of medical complications during this race and the preparation that we could suggest for this kind of activity. MATERIALS AND METHODS This is a descriptive, retrospective case series study. Follow-up consisted of sending out a questionnaire and performing individual interviews. RESULTS A total of 23 participants including 1 woman and 22 men; mean age of 46.5 years (range: 35-59) entered the race. The race lasted for 39 to 52 days with participants rowing between 10 and 12 h/day. Nine participants dropped out. Energy intake was 4500 to 6000 kcal/day and fluid intake was 4 to 5.5 L/day. Mean weight loss was 13.3 kg. The resting period was 6 ± 1 h/24 h divided into 1.5 to 2 h periods essentially during darkness. A total of 92% of the racers required medical care for dermatological problems; other conditions requiring medical care were: tendinitis in 10 cases, diarrhoea in 4, moderate to severe seasickness in 4, hallucinations in 3, panic attacks in 2, burns in 2, and disembarkation syndrome ("land sickness") lasting from 45 min to 6 h in 13. CONCLUSIONS Physiological and psychological impact of this type of event is still unclear. The most common medical problems are dermatological, rheumatological complications and minor trauma. Medical and psychological preparation should be offered to candidates for these competitions.
Complex BPF for Low-IF Receivers with an Automatic Digital Tuning Circuit

We explore an architecture and implementation of automatic digital tuning circuit for complex BPF in low-power and low-cost transceivers. Active RC filter realization presents an area advantage of 2.35 over gm-C filter. The principle of simultaneous tuning on center frequency and bandwidth through the calibration of a capacitor array is illustrated, and a scalable automatic digital tuning circuit with only 835 gates is presented. The developed capacitor tuning technique can achieve a tuning error below plusmn3.5%, and reduce a peaking in the passband of filter characteristics. An experimental tunable complex BPF is designed using a 0.18 mum CMOS, and can successfully reduce the tuning error from -20% before the tuning to below plusmn2.5%.
The titration constants of some amides and dipeptides in relation to alcohol and formaldehyde titrations of amino-N.

MEASUREMENT of the titration constants of simple peptides is of biochemical interest for two reasons. Firstly, it provides information necessary for careful titrimetric estimation of amino-N in biological fluids or enzymic proteolysates [Richardson, 1934, 1, 2]. Secondly, it facilitates interpretation of protein titration curves by helping to define the change of titration constant which results from peptide formation [Cohn, 1931]. For gelatin hydrolysates and various synthetic dipeptides, suitable data are already available [Cannan and Muntwyler, 1930; Greenstein, 1933; and others]. There is therefore no difficulty in deducing the extent of error due to these substances in alkalimetric formaldehyde or alcohol titrations ofamino-N [Richardson, 1934, 2]. Yet there exists an important group of substances containing amino-N about which there has been insufficient information hitherto. These, the aminoacid amides, may be quite plentiful in certain plant extracts and probably of enzymic proteolysates [cf. Melville, 1935]. Titration constants for certain typical derivatives have therefore been examined, together with data for some peptides of possibly distinctive behaviour. In addition, the usefulness of isoglutamine as a readily synthesised buffer of value in peptidase experiments is described. EXPERIMENTAL.
Elevated maternal hemoglobin A1c in early pregnancy and major congenital anomalies in infants of diabetic mothers.

PERINATAL mortality has decreased in pregnancies complicated by diabetes mellitus.1 As losses from stillbirths, intrapartum asphyxia, and hyaline-membrane disease diminish, major congenital anomalies emerge as the most important causes of mortality in infants of diabetic mothers.1 , 2 The overall incidence of major anomalies was 6 to 9 per cent in several large studies of such infants1 2 3 — three to four times that found in a general neonatal population.4 Fetal malformations occur before eight weeks of gestation (postmenstrual dates), when most diabetic pregnant women have not yet come to medical attention.5 Until recently, there has been no objective method to assess control .
Lipopeptide biosurfactants from Paenibacillus polymyxa inhibit single and mixed species biofilms

Although biofilms are recognised as important in microbial colonisation, solutions to their inhibition are predominantly based on planktonic assays. These solutions have limited efficacy against biofilms. Here, a series of biofilm-orientated tests were used to identify anti-biofilm compounds from marine micro-flora. This led to the isolation of a complex of anti-biofilm compounds from an extract of Paenibacillus polymyxa (PPE). A combination of rpHPLC and mass spectrometry identified the principle components of PPE as fusaricidin B (LI-FO4b) and polymyxin D1, with minor contributions from surfactins. This complex (PPE) reduced the biofilm biomass of Bacillus subtilis, Micrococcus luteus, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus bovis. In contrast, ampicillin was only effective against S. aureus. PPE also inhibited a self-assembling marine biofilm (SAMB) in co-incubation assays by 99.3% ± 1.9 and disrupted established SAMB by 72.4% ± 4.4, while ampicillin showed no significant reduction. The effectiveness of this complex of lipopeptides against single and multispecies biofilms suggests a future role in biofilm prevention strategies.
Discontinuous carbon dioxide release in the Eastern lubber grasshopper Romalea guttata and its effect on respiratory transpiration

Ventilatory patterns were examined in the Eastern lubber grasshopper Romalea guttata and correlated with respiratory transpiration. Discontinuous release of CO2 was only observed in quiescent individuals during their scotophase. Interburst periods (spiracles closed) alternated with bouts of CO2 emission and O2 consumption (burst phase); no true ‘flutter’ phase was observed. Cycle duration decreased with increasing temperature in both hydrated and dehydrated individuals. Metabolic rates for this large, sluggish species are lower than those reported for smaller and/or more active grasshoppers. Water loss rates fell within an expected range of values for arthropods from mesic environments. Respiratory transpiration accounted for only 1.9-3.9 % of the total water loss between 15 and 30 sC and for only 7 % of the water loss during the burst phase of the cycle. These data indicate that the cyclic release of CO2 in this adult insect does not result in substantial savings of water.
Absence of Left Pulmonary Artery in Tetralogy of Fallot with Absent Pulmonary Valve Syndrome

The rare combination of tetralogy of Fallot (TOF), absent pulmonary valve syndrome (APVS), and absent left pulmonary artery (ALPA) is reviewed herein. Children with TOF with APVS and ALPA should be closely monitored, even if they are asymptomatic or mildly symptomatic, and should undergo elective surgery at the end of infancy. doi: 10.1111/jocs.12461 (J Card Surg 2015;30:104–107)
Human identification using facial curves with extensions to joint shape-texture analysis

Recognition of human beings using shapes of their full facial surfaces is a difficult problem. Our approach is to approximate a facial surface using a collection of (closed) facial curves, and to compare surfaces by comparing their corresponding curves. The method is further strengthened by the use of texture maps (video images) associated with these faces. Using the commonly used spectral representation of a texture image, i.e. filter images using Gabor filters and compute histograms as image representations, we can compare texture images by comparing their corresponding histograms using the chi-squared distance. A combination of shape and texture metrics provides a method to compare textured, facial surfaces, and we demonstrate its application in face recognition using 240 facial scans of 40 subjects.
Comparison of methods to determine the centre of resistance of teeth

In orthodontic treatment, the locations of the centre of resistance (CR) of individual teeth and the applied load system are the major determinants for the type of tooth movement achieved. Currently, CR locations have only been specified for a relatively small number of tooth specimen for research purposes. Analysing cone beam computed tomography data samples from three upper central incisors, this study explores whether the effort to establish accurate CR estimates can be reduced by (i) morphing a pre-existing simplified finite element (FE) mesh to fit to the segmented 3D tooth-bone model, and (ii) individualizing a mean CR location according to a small parameter set characterising the morphology of the tooth and its embedding. The FE morphing approach and the semi-analytical approach led to CR estimates that differ in average only 0.04 and 0.12 mm respectively from those determined by very time-consuming individual FE modelling (standard method). Both approaches may help to estimate the movement of individual teeth during orthodontic treatment and, thus, increase the therapeutic efficacy.
Crystal structure of the motor domain of a class‐I myosin

The crystal structure of the motor domain of Dictyostelium discoideum myosin‐IE, a monomeric unconventional myosin, was determined. The crystallographic asymmetric unit contains four independently resolved molecules, highlighting regions that undergo large conformational changes. Differences are particularly pronounced in the actin binding region and the converter domain. The changes in position of the converter domain reflect movements both parallel to and perpendicular to the actin axis. The orientation of the converter domain is ∼30° further up than in other myosin structures, indicating that MyoE can produce a larger power stroke by rotating its lever arm through a larger angle. The role of extended loops near the actin‐binding site is discussed in the context of cellular localization. The core regions of the motor domain are similar, and the structure reveals how that core is stabilized in the absence of an N‐terminal SH3‐like domain.
DIRECTIONAL POSITIVE FEEDBACK AND PATTERN AT AN ALPINE TREELINE

DIRECTIONAL POSITIVE FEEDBACK AND PATTERN AT AN ALPINE TREELINE KATHRYN J. ALFTINE Earth Systems Science and Policy California State University at Monterey Bay, Seaside,CA The spatial pattern at alpine treeline may be part of a feedback process in which wind plays a central role. The basic aspects of such a feedback are embedded in a cellular automaton. Spatial metrics of the patterns generated by this simulation and those of observed at a windy treeline site are ordinated using PCA. Only the simulations that include a directionally weighted feedback fall close to the observed sites in ordination space. MANOVA indicates that the directionally weighted feedback is most important in structuring the treeline pattern, but that random hotspots for establishment and the overall steepness of the environmental gradient from forest to tundra in
Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex.

The initiation of anaphase and exit from mitosis depend on the activation of the anaphase-promoting complex/cyclosome (APC/C), a multicomponent, ubiquitin-protein ligase. The WD-repeat protein called p55(CDC)(Cdc20) directly binds to and activates APC/C. By using yeast two-hybrid screening, we found that cyclin A, a critical cell cycle regulator in the S and G2/M phases, specifically interacts with p55(CDC). Ectopically expressed p55(CDC) and cyclin A form a stable protein complex in mammalian cells. The p55(CDC)-cyclin A interaction occurs through the region containing the WD repeats of p55(CDC) and the region between the destruction box and the cyclin box of cyclin A. In addition to the physical interaction, p55(CDC) is phosphorylated by cyclin A-associated kinase. These findings suggest that the function of p55(CDC) is mediated or regulated by its complex formation with cyclin A.
Differentiation of Resistance Phenotypes among Erythromycin-Resistant Pneumococci

ABSTRACT Laboratory differentiation of erythromycin resistance phenotypes is poorly standardized for pneumococci. In this study, 85 clinical isolates of erythromycin-resistant (MIC ≥ 1 μg/ml)Streptococcus pneumoniae were tested for the resistance phenotype by the erythromycin-clindamycin double-disk test (previously used to determine the macrolide resistance phenotype inStreptococcus pyogenes strains) and by MIC induction tests, i.e., by determining the MICs of macrolide antibiotics without and with pre-exposure to 0.05 μg of erythromycin per ml. By the double-disk test, 65 strains, all carrying the erm(AM) determinant, were assigned to the constitutive macrolide, lincosamide, and streptogramin B resistance (cMLS) phenotype, and the remaining 20, all carrying the mef(E) gene, were assigned to the recently described M phenotype; an inducible MLS resistance (iMLS) phenotype was not found. The lack of inducible resistance to clindamycin was confirmed by determining clindamycin MICs without and with pre-exposure to subinhibitory concentrations of erythromycin. In macrolide MIC and MIC-induction tests, whereas homogeneous susceptibility patterns were observed among the 20 strains assigned to the M phenotype by the double-disk test, two distinct patterns were recognized among the 65 strains assigned to the cMLS phenotype by the same test; one pattern (n = 10; probably that of the true cMLS isolates) was characterized by resistance to rokitamycin also without induction, and the other pattern (n = 55; designated the iMcLS phenotype) was characterized by full or intermediate susceptibility to rokitamycin without induction turning to resistance after induction, with an MIC increase by more than three dilutions. A triple-disk test, set up by adding a rokitamycin disk to the erythromycin and clindamycin disks of the double-disk test, allowed the easy differentiation not only of pneumococci with the M phenotype from those with MLS resistance but also, among the latter, of those of the true cMLS phenotype from those of the iMcLS phenotype. While distinguishing MLS from M resistance in pneumococci is easily and reliably achieved, the differentiation of constitutive from inducible MLS resistance is far more uncertain and is strongly affected by the antibiotic used to test inducibility.
The viewing graph

The problem we study is: given N views and a subset of the (/sub 2//sup N/) interview fundamental matrices, which of the other fundamental matrices can we compute using only the pre-computed fundamental matrices. This has applications in 3D (three-dimensional) reconstruction and when we want to reproject an area of one view on another, or to compute epipolar lines when the correspondence problem is too difficult to compute between every two views. A complete solution using linear algorithms to compute the missing fundamental matrices are given for up to six views. In many cases problems with more than six views can also be handled.
Outcome Measures for Evaluating Intimate Partner Violence Programs Within Clinical Settings: A Systematic Review of the Literature

Background: Multiple intimate partner violence (IPV) identification and assistance programs have been implemented across clinical settings. The results of these studies are inconclusive and frequently conflicting, resulting in clinical uncertainty and controversy regarding the merits of IPV identification and assistance programs. We aimed to describe the choice of outcome measures used in previously published randomized trials of IPV identification and assistance programs. Method: A comprehensive literature search was conducted in the Medline, Embase, PyscInfo, and CENTRAL databases. The outcomes assessed in each included study were extracted and categorized, and the methodological quality of each eligible study was assessed using the Cochrane Risk of Bias tool. Results: Of 20 eligible studies, 6 evaluated IPV identification programs and 14 studies examined IPV assistance programs. The included studies used 48 different outcomes that we classified into 10 categories. For identification studies, the most commonly used outcome categories were IPV disclosure (66.7%) and resource use (66.7%). The most commonly used outcome categories for the IPV assistance studies included IPV recurrence and severity (64.3%) and health outcomes (50%). The included studies demonstrated a number of methodological limitations as identified by the Cochrane Risk of Bias instrument. Conclusions: IPV identification and assistance programs are evaluated using many different outcome measures. Although this diversity enriches the IPV literature, it makes it challenging to compare studies. The results of this review highlight the challenges of conducting research in the field of IPV and the complexity of selecting, measuring, and interpreting outcomes.