Miracle-dz/UniFAR-FTUs huggingface dataset:
Bridging the gap between rodents and humans: The role of non‐human primates in oxytocin research

Oxytocin (OT), a neuropeptide that acts in the brain as a neuromodulator, has been long known to shape maternal physiology and behavior in mammals, however its role in regulating social cognition and behavior in primates has come to the forefront only in the recent decade. Many of the current perspectives on the role of OT in modulating social behavior emerged first from studies in rodents, where invasive techniques with a high degree of precision have permitted the mechanistic dissection of OT‐related behaviors, as well as their underlying neural circuits in exquisite detail. In parallel, behavioral and imaging studies in humans have suggested that brain OT may similarly influence human social behavior and neural activity. These studies in rodents and humans have spurred interest in the therapeutic potential of targeting the OT system to remedy deficits in social cognition and behavior that are present across numerous psychiatric disorders. Yet there remains a tremendous gap in our mechanistic understanding of the influence of brain OT on social neural circuitry between rodents and man. In fact, very little is known regarding the neural mechanisms by which exogenous or endogenous OT influences human social cognition, limiting its therapeutic potential. Here we discuss how non‐human primates (NHPs) are uniquely positioned to now bridge the gaps in knowledge provided by the precise circuit‐level approaches widely used in rodent models and the behavioral, imaging, and clinical studies in humans. This review provides a perspective on what has been achieved, and what can be expected from exploring the role of OT in shaping social behaviors in NHPs in the coming years.
Species-Specific Auditory Forebrain Responses to Non-Learned Vocalizations in Juvenile Blackbirds

Species recognition mediates the association of individuals with conspecifics. Learned cues often facilitate species recognition via early social experience with parents and siblings. Yet, in some songbirds, the production of species-typical vocalizations develops in the absence of early social experiences. Here, we investigate the auditory-evoked neural responses of juvenile red-winged blackbirds (Agelaius phoeniceus), a nonparasitic (parental) species within the Icterid family and contrast these results with a closely related Icterid parasitic species that lacks parental care, the brown-headed cowbird (Molothrus ater). We demonstrate that immediate early gene (IEG) activity in the caudomedial mesopallium (CMM) is selectively evoked in response to conspecific non-learned vocalizations in comparison to 2 types of heterospecific non-learned vocalizations, independent of the acoustic similarity patterns between the playback stimuli. This pattern, however, was not detected in the caudomedial nidopallium (NCM). Because the red-winged blackbird is a parental species, the conspecific non-learned vocalization is presumably a familiar sound to the juvenile red-winged blackbird, whereas the heterospecific non-learned vocalizations are novel. We contrast results reported here with our recent demonstration of selective IEG induction in response to non-learned conspecific vocalizations in juvenile parasitic brown-headed cowbirds, in which conspecific non-learned vocalizations are presumably novel. In this case, selective IEG induction from conspecific non-learned vocalization occurred within NCM but not within CMM. By comparing closely related species with stark differences in the early exposure to conspecifics, we demonstrate that CMM and NCM respond to familiar vs. novel non-learned vocalizations in a manner that parallel previously reported regional responses to learned vocalizations such as conspecific songs.
Expression and clinical significance of autophagic protein LC3B and EMT markers in gastric cancer

Background and aim Gastric cancer (GC) is a fatal malignancy with high rate of recurrence and metastasis. Here, we investigated the correlations between the expression of autophagic protein LC3B and 2 epithelial–mesenchymal transition-related proteins (E-cadherin and Vimentin) and the clinicopathological factors and prognosis of patients with GC. Materials and methods The expression of LC3B, E-cadherin, and Vimentin in GC samples (110 cases) and paracarcinoma tissues (40 cases) was analyzed using the Oncomine databases and further detected by immunohistochemistry. The correlations among these markers expression and clinicopathological features in GC were analyzed. The patients were followed for survival analysis. Results Compared to the nontumor tissues, the expression of LC3B and Vimentin proteins were significantly elevated in GC tissues, but the E-cadherin expression was decreased (all p<0.05). Interestingly, LCB expression was positively correlated with Vimentin (r=0.320, p=0.001) and negatively associated with E-cadherin expression (r= −0.484, p<0.001) in GC. The expression of these markers was closely related to tumor differentiation, T classification, TNM stage, and lymph node metastasis (all p<0.05). Furthermore, survival analyses and screening Kaplan–Meier plotter database revealed that GC patients with high LC3B and Vimentin expression levels had a poorer clinical outcome than those with low expression. Conversely, high E-cadherin expression was linked with favorable overall survival (all p<0.05, log-rank test). Multivariate survival analysis demonstrated that LC3B, E-cadherin, and Vimentin expression were independent prognostic factors of GC patients. Conclusion LC3B, E-cadherin, and Vimentin may play an important role in the tumorigenesis of GC, and these marker expressions may serve as additional prognostic indicators for overall survival of patients. The interactions of autophagy and epithelial–mesenchymal transition in GC merits further investigation.
The Role of T Lymphocytes in Skeletal Muscle Repair From Traumatic and Contraction-Induced Injury

Skeletal muscle is prone to damage from a range of stimuli, and initiates a robust repair process that requires the participation of immune cells. Among the more well characterized immune cells involved in muscle repair are those of the myeloid lineage, including neutrophils, macrophages, monocytes, and eosinophils. More recently, studies have begun to elucidate the role of the lymphoid-derived immune cells, most notably T lymphocytes (T-cells), in the complex processes of muscle repair. Though T-cells have been traditionally been associated with pathological degeneration of skeletal muscle in disease, recent studies show that T-cells are instrumental in the repair/regeneration process following severe muscle damage in mice. Furthermore, a few studies using basic immunohistochemical assays have shown that T-cells accumulate in human skeletal muscle in the days following contraction-induced muscle damage. The functional significance of T-cells in the repair and adaptation process following contraction-induce muscle damage remains uncertain, and is an active area of intense investigation. This mini-review summarizes recent findings on the involvement of T-cells in skeletal muscle repair.
A Novel Mobile Data Contract Design with Time Flexibility

In conventional mobile data plans, the data is associated with a fixed period (e.g., one month) and the unused data will be cleared at the end of each period. To take advantage of consumers’ heterogeneous demands across different periods and meanwhile to provide more time flexibility, some mobile data service providers (SP) have offered data plans with different lengths of period. In this paper, we consider the data plan design problem for a single SP, who provides data plans with different lengths of period for consumers with different characteristics of data demands. We propose a contract-theoretic approach, wherein the SP offers a period-price data plan contract which consists of a set of period and price combinations, indicating the prices for data with different periods. We study the optimal data plan contract designs under two different models: discrete and continuous consumer-type models, depending on whether the consumer type is discrete or continuous. In the former model, each type of consumers are assigned with a specific period-price combination. In the latter model, the consumers are first categorized into a finite number of groups, and each group of consumers (possibly with different types) are assigned with a specific period-price combination. We systematically analyze the incentive compatibility (IC) constraint and individual rationality (IR) constraint, which ensure each consumer to choose the data plan with the period-price combination intended for his type. We further derive the optimal contract that maximizes the SP’s expected profit, meanwhile satisfying the IC and IR constraints of consumers. Our numerical results show that our proposed optimal contract can increase the SP’s profit over 35% comparing with the conventional monthly-period data plan.
Statistisch basierte Sprachmodelle und maschinelle Übersetzung

Statistische Methoden finden derzeit in der Sprachtechnologie vielfache Verwendung. Ein Grundgedanke dabei ist das Trainieren von Programmen auf großen Mengen von Daten. Für das Trainieren von statistischen Sprachmodellen gilt zur Zeit das Motto „Je mehr Daten desto besser“. In unserem System zur maschinellen Übersetzung sehen wir eine fast konstante qualitative Verbesserung (gemessen als BLEU-Score) mit jeder Verdoppelung der monolingualen Trainingsdatenmenge. Selbst bei Mengen von ca. 20 Milliarden Wörtern aus Nachrichtentexten und ca. 200 Milliarden Wörtern aus Webseiten ist kein Abflachen der Lernkurve in Sicht. Dieser Artikel gibt kurze Einführungen in statistische maschinelle Übersetzung, die Evaluation von Übersetzungen mit dem BLEU-Score, und in statistische Sprachmodelle. Wir zeigen, welch starken Einfluß die Größe der Trainingsdaten des Sprachmodells auf die Übersetzungsqualität hat. Danach wird die Speicherung großer Datenmengen, das Trainieren in einer parallelen Architektur und die effiziente Verwendung der bis zu 1 Terabyte großen Modelle in der maschinellen Übersetzung beschrieben. Statistische m aschinelle Übersetzung Dieses Feld findet in den letzten Jahren mehr und mehr Interesse in der Forschung. Aufgrund der weltweit steigenden Verbreitung des Internets besteht auch ein steigender Bedarf an Übersetzungen von Texten, um Webseiten auch denjenigen Benutzern zugänglich zu machen, die die Originalsprache des Dokuments nicht verstehen. Leider lässt die Übersetzungsqualität der existierenden Systeme oft noch sehr viel zu wünschen übrig. Im Folgenden ein Beispiel für eine Übersetzung aus dem Arabischen ins Englische, bei dem die geringe Qualität ein Verstehen fast unmöglich macht: The Bradi: The inspectors need to “a few months” for end important their Paris 13 1 (aa so in in) the general manager for agency announced international for energy atomic Mohammed the Bradi today Monday that inspectors of international nze’ the weapons need to “a few months” for end important their in Iraq. Joumalistic Conference in end of meeting with French Extemal Minister of Dominique de Villepin that the inspectors said during “a few their need to important months for
T-Cell Responses in Adults During Natural Respiratory Syncytial Virus Infection

Background The pathogenesis of respiratory syncytial virus (RSV) in older adults may be due to age-related T-cell immunosenescence. Thus, we evaluated CD4 and CD8 T-cell responses during RSV infection in adults across the age spectrum. Methods Peripheral blood mononuclear cells collected during RSV infection in adults, age 26-96 years, were stimulated with live RSV and peptide pools representing F, M, NP, and G proteins and analyzed by flow cytometry. Results There were no significant age-related differences in frequency of CD4+ T cells synthesizing interferon (IFN)γ, interleukin (IL)2, IL4, IL10, or tumor necrosis factor (TNF)α or in CD8+IFNγ+ T cells. IL4+CD4+ T-cell numbers were low, as were IL13 and IL17 responses. However, in univariate analysis, CD4 T-cell IFNγ, IL2, IL4, IL10, and TNFα responses and CD8+IFNγ+ T cells were significantly increased with more severe illness requiring hospitalization. In multivariate analysis, viral load was also associated with increased T-cell responses. Conclusions We found no evidence of diminished RSV-specific CD4 or CD8 T-cell responses in adults infected with RSV. However, adults with severe disease seemed to have more robust CD4 and CD8 T-cell responses during infection, suggesting that disease severity may have a greater association with T-cell responses than age.
Preliminary Validation of Japanese Version of the Parental Burnout Inventory and Its Relationship With Perfectionism

Parenting is a precious experience and also a very hard task, which could result in parental burnout for some parents. The present study sought to validate a Japanese version of the Parental Burnout Inventory (PBI-J) by replicating and extending the pioneering work of Roskam et al. (2017). We conducted a web survey (N = 1200) to first validate the PBI-J and second to investigate the association between the PBI-J and perfectionism as a new interrelation. Similar to the prior study of Roskam et al. (2017), confirmatory factor analysis supported a model of three-factor structure of the PBI-J: emotional exhaustion, lack of personal accomplishment, and emotional distancing. In addition, we found low to moderate correlations of parental burnout with job burnout, parental stress, and depression. These findings provided initial evidence for validity of the PBI-J and suggested that parental burnout appeared to be different from job burnout. Our further evaluation of perfectionism confirmed such a difference between parental and job burnout by showing that parental perfectionism [i.e., combination of parental personal standards (PS) and parental concern over mistakes (CM)] has a unique contribution to parental burnout than does job perfectionism (i.e., combination of job PS and job CM). In addition, CM was positively correlated with burnout in both domains whereas the associations between PS and burnout were more complex. Finally, the proportion of parents experiencing burnout was estimated to lie somewhere between 4.2 and 17.3% in Japan. Overall, the present study confirmed preliminary validity of the PBI-J and found that parental perfectionism is one of the vulnerability factors in parental burnout.
Supplementation with polyunsaturated fatty acids (PUFAs) in the management of attention deficit hyperactivity disorder (ADHD)

While pharmacotherapy and psychosocial interventions are recommended as the primary frontline treatment for attention deficit hyperactivity disorder (ADHD), alternative approaches to managing ADHD are becoming increasingly popular among patients and their families. Supplementation with polyunsaturated fatty acids (PUFAs) is an example of this. PUFA supplementation is not recommended by guidelines for managing ADHD; however, patients may still decide to use it. To provide direction to healthcare professionals (HCPs) managing ADHD, eight international experts in the field of adult and child ADHD came together for the Continuum Education Board: Omega Supplements in ADHD meeting. This commentary summarises the panel's consensus that current evidence suggests PUFA supplementation has a small beneficial effect on behaviour in children with ADHD, and that further high-quality research is needed to clearly evaluate and define its role in the management of ADHD of children, adolescents and adults. The panel concluded that in cases where patients use PUFA supplementation, HCPs should be comfortable explaining the potential gains that they may have and their possible side effects. The panel also concluded HCPs should not reinforce the idea that PUFA supplementation should replace treatment approaches with a more robust evidence base for managing ADHD.
Bone Turnover Markers Are Not Associated With Hip Fracture Risk: A Case‐Control Study in the Women's Health Initiative

Current guidelines recommend that serum C‐terminal telopeptide of type I collagen (CTX) and serum procollagen type 1 aminoterminal propeptide (PINP), measured by standardized assays, be used as reference markers in observational and interventional studies. However, there are limited data to determine whether serum CTX and PINP are associated with hip fracture risk among postmenopausal women. We determined the associations of serum CTX and serum PINP with hip fracture risk among postmenopausal women aged 50 to 79 years at baseline. We performed a prospective case‐control study (400 cases, 400 controls) nested in the Women's Health Initiative Observational Study, which enrolled participants at 40 US clinical centers. Cases were women with incident hip fracture not taking osteoporosis medication; hip fractures were confirmed using medical records. Untreated controls were matched by age, race/ethnicity, and date of blood sampling. Serum CTX and serum PINP were analyzed on 12‐hour fasting blood samples. The main outcome measure was incident hip fracture risk (mean follow‐up 7.13 years). After adjustment for body mass index, smoking, frequency of falls, history of fracture, calcium and vitamin D intake, and other relevant covariates, neither serum CTX level nor serum PINP level was statistically significantly associated with hip fracture risk (CTX ptrend = 0.22, PINP ptrend = 0.53). Our results do not support the utility of serum CTX level or PINP level to predict hip fracture risk in women in this age group. These results will inform future guidelines regarding the potential utility of these markers in fracture prediction. © 2018 American Society for Bone and Mineral Research.
Facing Multiple Attacks in Adversarial Patrolling Games with Alarmed Targets

We focus on adversarial patrolling games on arbitrary graphs, where the Defender can control a mobile resource, the targets are alarmed by an alarm system, and the Attacker can observe the actions of the mobile resource of the Defender and perform different attacks exploiting multiple resources. This scenario can be modeled as a zero-sum extensive-form game in which each player can play multiple times. The game tree is exponentially large both in the size of the graph and in the number of attacking resources. We show that when the number of the Attacker's resources is free, the problem of computing the equilibrium path is NP-hard, while when the number of resources is fixed, the equilibrium path can be computed in poly-time. We provide a dynamic-programming algorithm that, given the number of the Attacker's resources, computes the equilibrium path requiring poly-time in the size of the graph and exponential time in the number of the resources. Furthermore, since in real-world scenarios it is implausible that the Defender knows the number of attacking resources, we study the robustness of the Defender's strategy when she makes a wrong guess about that number. We show that even the error of just a single resource can lead to an arbitrary inefficiency, when the inefficiency is defined as the ratio of the Defender's utilities obtained with a wrong guess and a correct guess. However, a more suitable definition of inefficiency is given by the difference of the Defender's utilities: this way, we observe that the higher the error in the estimation, the higher the loss for the Defender. Then, we investigate the performance of online algorithms when no information about the Attacker's resources is available. Finally, we resort to randomized online algorithms showing that we can obtain a competitive factor that is twice better than the one that can be achieved by any deterministic online algorithm.
Analysing ecological networks of species interactions

Network approaches to ecological questions have been increasingly used, particularly in recent decades. The abstraction of ecological systems – such as communities – through networks of interactions between their components indeed provides a way to summarize this information with single objects. The methodological framework derived from graph theory also provides numerous approaches and measures to analyze these objects and can offer new perspectives on established ecological theories as well as tools to address new challenges. However, prior to using these methods to test ecological hypotheses, it is necessary that we understand, adapt, and use them in ways that both allow us to deliver their full potential and account for their limitations. Here, we attempt to increase the accessibility of network approaches by providing a review of the tools that have been developed so far, with – what we believe to be – their appropriate uses and potential limitations. This is not an exhaustive review of all methods and metrics, but rather, an overview of tools that are robust, informative, and ecologically sound. After providing a brief presentation of species interaction networks and how to build them in order to summarize ecological information of different types, we then classify methods and metrics by the types of ecological questions that they can be used to answer from global to local scales, including methods for hypothesis testing and future perspectives. Specifically, we show how the organization of species interactions in a community yields different network structures (e.g., more or less dense, modular or nested), how different measures can be used to describe and quantify these emerging structures, and how to compare communities based on these differences in structures. Within networks, we illustrate metrics that can be used to describe and compare the functional and dynamic roles of species based on their position in the network and the organization of their interactions as well as associated new methods to test the significance of these results. Lastly, we describe potential fruitful avenues for new methodological developments to address novel ecological questions.
Mechanisms and Drug Development in Atrial Fibrillation

Atrial fibrillation is a highly prevalent cardiac arrhythmia and the most important cause of embolic stroke. Although genetic studies have identified an increasing assembly of AF-related genes, the impact of these genetic discoveries is yet to be realized. In addition, despite more than a century of research and speculation, the molecular and cellular mechanisms underlying AF have not been established, and therapy for AF, particularly persistent AF, remains suboptimal. Current antiarrhythmic drugs are associated with a significant rate of adverse events, particularly proarrhythmia, which may explain why many highly symptomatic AF patients are not receiving any rhythm control therapy. This review focuses on recent advances in AF research, including its epidemiology, genetics, and pathophysiological mechanisms. We then discuss the status of antiarrhythmic drug therapy for AF today, reviewing molecular mechanisms, and the possible clinical use of some of the new atrial-selective antifibrillatory agents, as well as drugs that target atrial remodeling, inflammation and fibrosis, which are being tested as upstream therapies to prevent AF perpetuation. Altogether, the objective is to highlight the magnitude and endemic dimension of AF, which requires a significant effort to develop new and effective antiarrhythmic drugs, but also improve AF prevention and treatment of risk factors that are associated with AF complications.