Miracle-dz/UniFAR-FTUs huggingface dataset:
Contribution a l'etude du phenotype chez le scottish fold

La mutation genetique, « folded ear », responsable de la pliure des oreilles vers l'avant chez les chats de race Scottish Fold, est autosomique dominante. Les sujets porteurs de ce gene developpent a des degres divers des anomalies osteo-articulaires sur les extremites distales des membres et sur la queue. Elles correspondent a une osteochondrodysplasie et sont decelables aux examens clinique et radiographique. Dans les annees soixante-dix, des scientifiques ont montre que ces anomalies osseuses sont toujours presentes chez les individus homozygotes pour le gene « folded ear » ce qui a conduit a interdire les mariages entre deux chats a oreilles pliees. Recemment, ces lesions ont egalement ete suspectees sur des individus heterozygotes. Notre etude, destinee a dresser un bilan dans les elevages francais de race Scottish Fold, est basee sur une etude parallele de pedigrees et de cliches radiographiques sur des chats Scottish Fold, « Scottish Straight » et British Shorthair. Elle confirme que les chats de race Scottish Fold heterozygotes ont des anomalies osteo-articulaires de gravite variable et decelables a l'examen radiographique. Aucun des seize chats Scottish Fold examines n'etait indemne d'anomalie radiographique osteo-articulaires. Le gene « folded ear » semble determinant dans la presence de l'osteochondrodysplasie chez les chats Scottish Fold. La presence de polygenes et ou de QTLs deleteres aggravants n'a pu etre clairement demontree dans cette etude. Ainsi, la cause de la variabilite des lesions et des troubles locomoteurs observee chez les Scottish Fold heterozygotes reste a expliquer.
Risk assessment of stability loss: Experimental investigations of weak bus bars

The objective of this paper is to estimate the risk of experiencing stability loss at a voltage-controlled bus bar of an electrical power grid. Methods used for estimating and predicting imminent stability losses are presented together with underlying concepts. The approach is based on observing the current power flow at the node of the observed grid. The method uses no a priori knowledge of specific metadata nor does it need detailed models. A voltage control is not required; however, this does not restrict the applicability of the current method, provided the reactive power used for control is included in the observed load flow at the node under observation. Findings from both numerical simulations and experiments in a real power system are presented. For the experimental environment, the test facility for energy systems and wind power plants at the Jade University in Wilhelmshaven has been used. This environment offers the possibility of investigations in reproducible scenarios for energy systems. Here it is possible and also permissible to provoke system states which, in the field, is feasible only in extremely exceptional cases, if at all. So, in the first step evidence for an impending collapse due to stability loss is identified and subsequently the collapse is observed.
Test In the Era of "What You see Is NOT What You Get"

Increasing design complexities conspire to threaten long held assumptions about the predictability of design closure. Yield may no longer be dominated by process issues, but equally by unexpected and unpredicted design weaknesses. Structural test has been developed on the presumption that the main purpose of test is to detect localized manufacturing process defects. The unpredictability of design closure, by contrast, mainly affects parametric performance. One interesting question, hence, is to what extent structural test methods are capable of or can be extended to validate the parametric performance. We also explore how manufacturing test can evolve from being a simple pass/fail screen to becoming a capable contributor to continuous design-process characterization.
Haematopoietic cell transplantation in patients with Fanconi anaemia using alternate donors: results of a total body irradiation dose escalation trial

Allogeneic haematopoietic cell transplantation (HCT) is the only therapeutic modality capable of correcting the haematologic manifestations of Fanconi anaemia (FA). However, HCT from alternative donors has been associated with poor survival. Between June 1993 and July 1998, 29 FA patients (median age 12·1 years; range 3·7–48·5 years) were enrolled in a prospective phase I–II dose escalation study. All patients were treated with cyclophosphamide 40 mg/kg, total body irradiation (TBI) 450 cGy or 600 cGy and antithymocyte globulin (ATG), followed by HCT from an alternative donor. Graft‐versus‐host disease (GVHD) prophylaxis consisted of cyclosporin A for 6 months, short course methylprednisolone (2 mg/kg/day) between days +5 and +19 and marrow T‐cell depletion by counterflow elutriation. The probability of developing grade III–IV toxicity was 17% (95% CI 3–31%). For the 25 marrow recipients, the probability of neutrophil engraftment (ANC̊ 0·5 × 109/l by day 45) was 63% (95% CI 42–82%). Probabilities of grade II–IV acute GVHD and chronic GVHD were 32% (95%CI 10–54%) and 0% respectively. With a median follow‐up of 18 months, the probability of survival for the entire cohort at 1 year was 34% (95% CI 17–51%). The presence of lymphocyte somatic mosaicism [i.e. the presence of diepoxybutane (DEB)‐insensitive cells] was associated with a significantly increased risk of graft failure. Disappointingly, the use of higher dose TBI and post‐transplant ATG did not improve engraftment. More effective peritransplant immunosuppression, especially in FA patients with somatic mosaicism, was required to overcome the barrier of graft rejection. New conditioning regimens adapted to each individual's alkylator sensitivity are needed to improve the outcome of alternative donor HCT for FA.
A Multidimensional Measure of Pain Interference: Reliability and Validity of the Pain Disability Assessment Scale

ObjectiveMeasuring outcomes across multiple domains is essential for an adequate understanding of chronic pain and the effects of pain treatment. Pain interference reflects the negative effects of pain on functioning, and is recognized as a critical outcome domain. The Pain Disability Assessment Scale (PDAS) contains items that assess the negative effects of pain on broad spectrum pain interference domains. The purpose of this study was to examine the factor structure, reliability, and validity of the PDAS. MethodsOne hundred sixty-four Japanese patients with chronic pain were administered the PDAS, the Brief Pain Inventory, and the Hospital Anxiety and Depression Scale. ResultsThe findings support a 3 factor structure of the PDAS items, as well as a high level of internal consistency of the scales created from these factors (Cronbach &agr;'s range: 0.87 to 0.95). Validity of the 3 scales was supported through their significant associations, in hypothesized directions, with measures of pain intensity, anxiety, depression, and another established measure of pain interference, as well as differences in PDAS scores between patients with versus without back pain. ConclusionsThe PDAS may be useful when researchers or clinicians require a multidimensional measure of the effects of pain on a patient's life.
Electrodermal Presentiments of Future Emotions

In previously reported double-blind experiments, electrodermal activity (EDA) monitored during display of randomly selected photographs showed that EDA was higher before emotional photos than before calm photos (p ¼ 0.002). This differential effect, suggestive of precognition, was dubbed ''presentiment. '' Three new double-blind experiments were conducted in an attempt to replicate the original studies using the same basic design, but with new physiological monitoring hardware, software, stimulus photos, subject populations, and testing environments. The three replications involved 109 participants who together contributed 3,709 trials. The new studies again showed higher EDA before emotional photos than before calm photos (p ¼ 0.001). All four experiments combined involved 133 participants and 4,569 trials; the associated weighted mean effect size (per trial) was e ¼ 0.064 6 0.015, over 4 standard errors from a null effect. As a more general test, presentiment predicts a positive correlation between pre-stimulus EDA and independently assessed emotionality ratings of the photo targets. The observed correlation across all four experiments was significantly positive (p ¼ 0.008). Consideration of alternative explanations, including expectation, sensory cues, hardware or software artifacts, inappropriate analyses, and anticipatory strategies, revealed no suitable candidates that could systematically generate the observed results. This series of four experiments, supported by successful replications conducted by other investigators, appears to demonstrate a small magnitude but statistically robust form of precognition in the human autonomic nervous system.
Mouse models of frontotemporal dementia

The pace of discovery in frontotemporal dementia (FTD) has accelerated dramatically with the discovery of new genetic causes and pathological substrates of the disease. MAPT/tau, GRN/progranulin, and C9ORF72 have emerged as common FTD genes, and TARDBP/TDP‐43, VCP, FUS, and CHMP2B have been identified as less common genetic causes. TDP‐43 and FUS have joined tau as common neuropathological substrates of the disease. Mouse models provide an important tool for understanding the role of these molecules in FTD pathogenesis. Here, we review recent progress with mouse models based on tau, TDP‐43, progranulin, VCP, and CHMP2B. We also consider future prospects for FTD models, including developing new models to address unanswered questions. There are also opportunities for capitalizing on conservation of the salience network, which is selectively vulnerable in FTD, and the availability of FTD‐related behavioral paradigms to analyze mouse models of the disease. Ann Neurol ANN NEUROL 2012;72:837–849
Formulation and Pharmacokinetics of HSA-core and PLGA-shell Nanoparticles for Delivering Gemcitabine

Gemcitabine-loaded core-shell nanoparticles (CSNPs), comprised of a cross-linked HSA-core and PLGA-shell, were prepared through a modified double emulsification method, and the processing parameters were systematically investigated. The optimized CSNPs had a particle size of 241 ± 36.2 nm and an encapsulation efficiency of 41.52%. The core-shell structure was characterized by optical microscope (OM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The amorphous nature of the encapsulated drug was confirmed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). An in vitro release study demonstrated that the CSNPs had an improved sustained release profile controlled by erosion of materials in combination with drug diffusion. In vivo pharmacokinetics of CSNPs obtained a bigger area under concentration-time curve (AUC), t1/2, and Cmax compared to free drug solution. The results suggest that HSA-PLGA-based CSNPs can be a promising carrier for the sustained release of gemcitabine.
Ten-year prospective study of public health problems associated with early drinking.

OBJECTIVE To compare early nondrinkers, experimenters, and drinkers on the prevalence of problem behaviors at grades 7 and 12 and at age 23 (N = 6338, 4265, and 3369, respectively). METHODS Results are based on longitudinal self-report data from individuals who were originally recruited from 30 California and Oregon schools at grade 7 (1985) and assessed again at grade 12 (1990) and at age 23 (1995). Logistic regression was used to develop weighted estimates of the prevalence of academic difficulties, employment problems, substance use, and delinquent and violent behaviors within the 3 drinking status groups at grades 7, 12, and/or at age 23. Huber variance estimates, which adjust for weighting and clustering of observations, were used to assess the statistical significance of differences across groups. RESULTS Early drinkers and experimenters were more likely than nondrinkers to report academic problems, substance use, and delinquent behavior in both middle school and high school. By young adulthood, early alcohol use was associated with employment problems, other substance abuse, and criminal and violent behavior. CONCLUSIONS Early drinkers do not necessarily mature out of a problematic lifestyle as young adults. Interventions for these high-risk youth should start early and address their other public health problems, particularly their tendency to smoke and use other illicit drugs.
miR-382 inhibits tumor growth and enhance chemosensitivity in osteosarcoma

Dysregulation of miRNAs is involved in osteosarcoma (OS). Here, we demonstrate that miR-382 is decreased in specimens of OS patients with a poor chemoresponse compared to those with a good chemoresponse. In addition, our clinical data show that decreased miR-382 was associated with poor survival in OS patients. Overexpression of miR-382 inhibited cell growth and chemoresistance by targeting KLF12 and HIPK3, respectively. In contrast, inhibition of miR-382 or overexpression of target genes stimulated OS cell growth and chemoresistance both in vitro and in vivo. Taken together, these findings suggest that miR-382 is a tumor suppressor miRNA and induction of miR-382 is a potential strategy to inhibit OS progression.
L'arganeraie dans l'économie rurale du sud-ouest marocain

L etude de la place occupee par l utilisation des peuplements d Arganier dans la dynamique des systemes agraires du sud-ouest marocain donne un exemple du niveau d imbrication qui peut exister dans certaines regions arides entre activites agricoles et forestieres, mais aussi dans la particuliere instabilite des equilibres biologiques et sociaux correspondants.
Time‐course and extent of retinal ganglion cell death following ablation of the superior colliculus in neonatal rats

This study has examined the deleterious effect of superior colliculus (SC) ablation on the viability of identified retinotectally projecting ganglion cells in the neonatal rat retina. The time‐course and extent of lesion‐induced retinal ganglion cell (rgc) death has been determined and an estimate obtained for the rate of clearance of individual dying neurons. In order to demonstrate the projection of rgcs to the SC and the subsequent death of these same neurons after SC lesions, the fluorescent dye diamidino yellow (DY) was injected into the left SC of anesthetized 2 day old Wistar rats (P2: day of birth = P0). DY retrogradely labels the nuclei of tectally projecting rgcs; if these identified rgcs subsequently die, their DY‐labelled nuclei become pyknotic and can be visualized in retinal wholemounts. At P4 the rats were again anesthetized and the injected area, seen as a yellow patch in the SC, was removed by aspiration. Rats were perfused 2 to 336 hours after the lesion and retinal wholemounts of the right eye were prepared. Control rats received only DY injections and were perfused at times corresponding to the lesioned animals. In three sham‐operated rats; the injected SC was reexposed at P4 but the tectal tissue was not removed. In each of the 42 rats that were analyzed, about 10% of the retina containing retrogradely labelled rgcs was counted; the number of pyknotic versus normally labelled rgcs was determined and changes in normal cell density were also assessed. Pyknotic rates in control and sham‐operated rats were similar (average O.8%, n = 11). In SC‐lesioned rats, the proportion of pyknotic DY‐labelled rgcs increased to about 2.5% 4 to 8 hours postlesion (PL); the peak period of death occurred at 23 hours PL (8.0%). The amount of pyknosis decreased thereafter and most dying cells had been eliminated by 50 hours PL. Phagocytosis of dying cells was a common feature of retinae in SC lesioned rats. In the long‐term (336 hours) rats, counts of normal DY‐labelled rgcs in corresponding regions of control and lesioned rats revealed an average decrease in rgc density of 47.3% after P4 tectal ablation. Calculations suggest a clearance time of about 3 hours for dying neonatal rgcs. © 1992 Wiley‐Liss, Inc.
Temperature and concentration calibration of aqueous polyvinylpyrrolidone (PVP) solutions for isotropic diffusion MRI phantoms

To use the “apparent diffusion coefficient” (Dapp) as a quantitative imaging parameter, well-suited test fluids are essential. In this study, the previously proposed aqueous solutions of polyvinylpyrrolidone (PVP) were examined and temperature calibrations were obtained. For example, at a temperature of 20°C, Dapp ranged from 1.594 (95% CI: 1.593, 1.595) μm2/ms to 0.3326 (95% CI: 0. 3304, 0.3348) μm2/ms for PVP-concentrations ranging from 10% (w/w) to 50% (w/w) using K30 polymer lengths. The temperature dependence of Dapp was found to be so strong that a negligence seems not advisable. The temperature dependence is descriptively modelled by an exponential function exp(c2 (T − 20°C)) and the determined c2 values are reported, which can be used for temperature calibration. For example, we find the value 0.02952 K-1 for 30% (w/w) PVP-concentration and K30 polymer length. In general, aqueous PVP solutions were found to be suitable to produce easily applicable and reliable Dapp-phantoms.
FlowIdentity: Software-defined network access control

Software-Defined Networking (SDN) is a new paradigm for building computer networks through the decoupling of the control and forwarding functions of network devices. This has provided not only an exciting opportunity for the industry and researchers to solve some of the most persistent networking problems, but also an environment where creative network applications and services are more easily developed and deployed to solve specific business needs. In this paper, we present FlowIdentity - a virtualized network access control function using OpenFlow protocol. FlowIdentity implements 802.1X framework in SDN architecture, combined with a novel authorization method through a stateful role-based firewall. Policy definition is based on high-level endpoints' role which can be dynamically updated and enforced directly on the centralized 802.1X authenticator. Our solution solves some outlined persistent challenges facing the traditional port-based access control method to provide an effective enterprise network access control solution, and also provides a platform that encourages network operators, equipment vendors and researchers to develop innovative alternatives to the current solutions.
Incentivos para la divulgación voluntaria de información: evidencia empírica sobre la información segmentada

Este estudio analiza los incentivos de las empresas espanolas para proporcionar informacion segmentada en sus cuentas anuales. El trabajo se centra en la teoria de los costes propietarios, que sostiene que los incentivos para publicar informacion son una funcion decreciente de estos costes potenciales; tambien considera la teoria de la senal, que proporciona una explicacion para la divulgacion completa de informacion; asi como los argumentos de la teoria de la agencia, que justifica la divulgacion para reducir los costes de las relaciones de agencia. En el analisis se consideran las cuentas anuales de una muestra de 76 empresas espanolas cotizadas durante el periodo 1993-1997. Se estiman modelos de regresion multivariante logit para analizar los incentivos para publicar informacion segmentada en un entorno en el que la regulacion es escasa. Nuestros resultados sugieren que los costes de agencia y los costes propietarios, medidos a traves del endeudamiento y el tamano, son potencialmente las mejores razones para explicar su divulgacion. Ademas, el trabajo revela la necesidad de clarificar la normativa respecto a lo que debe entenderse por segmentos de actividad
Low-Calorie Sweeteners and Weight Control — What the Science Tells Us Mechanisms for Sweetness 1 – 3

A remarkable amount of information has emerged in the past decade regarding sweet taste physiology. This article reviews these data,with a particular focus on the elucidation of the sweet taste receptor, its location and actions in taste transduction in themouth, its nontaste functions in the gastrointestinal tract (e.g., in enteroendocrine cells), and the brain circuitry involved in the sensory processing of sweet taste. Complications in the use of rodents to model human sweet taste perception and responses are also considered. In addition, information relating to low-calorie sweeteners (LCS) is discussed in the context of these issues. Particular consideration is given to the known effects of LCS on enteroendocrine cell function. J. Nutr. doi: 10.3945/jn.111. 149567.
Use fingerprint technology in developing country security

For over a century, fingerprints (FP) have been considered one of the most highly used methods for human recognition; automated biometric systems have only been available in recent years. FP recognition is becoming indispensable part of many identification systems in the world. This research present a proposed authentication system based on FP as biometric type and some of static credential personal information such as name and address date. The system generates a Unique Identification Number (ID) by combining FP features with user's personal information for accessing the system. One-to-one and one to more verification is used to verify user's identity for the application with high security level. The design model has been trained and tested using DB consisting of 100 images with selected FP's images for 30 persons. Result of FPs Matching rate is (100%) for end point by using SVM algorithm. The experimental work of the proposed system in this paper is that implementing a fingerprint-based investigation system for the Iraq country. The software was designed using Visual Studio 2013, ASP.net with C#, SQL server 2012, Windows Server 2012, and Microsoft Access 2010 programming language.
Dynamical Heterogeneity in Supported Lipid Bilayers

Planar-supported phospholipid bilayers are responsive surfaces that reconstruct when macromolecules adsorb. This review outlines the phenomenon of lipid diffusion “slaved” to or significantly controlled by that of macromolecular adsorbates. To elucidate such systems, we discuss the value of spatially resolved experiments at the few-molecule level, lipid diffusion compared in outer and inner leaflets of the supported bilayer, and a simple method to minimize defects by the strategy of “electrostatic stitching. ”
Dietary lipid level affects growth performance and nutrient utilisation of Senegalese sole (Solea senegalensis) juveniles

Over the last few years, several aspects of Senegalese sole (Solea senegalensis) culture have been developed and optimised but the dietary lipid level for optimal growth has never been determined. Hence, five isonitrogenous diets (56 % dietary protein) with increasing dietary lipid levels (4, 8, 12, 16 and 20 % DM) were fed to satiation to triplicate groups of twenty fish (mean initial weight 10 g). Fifteen tanks were randomly assigned one of the five diets. Feed was distributed using automatic feeders, and fish were fed over a 16-week period. At the end of the experiment the fish fed on diets containing the two lowest dietary lipid levels (4 and 8 %) showed a 3-fold body-weight increase with a significantly higher daily growth index than fish fed higher lipid levels (1·2 v. 0·8). Moreover, these fish displayed a significantly lower dry feed intake (12 g/kg per d) and feed conversion ratio (1·0) compared with fish fed higher lipids levels (16–19 g/kg per d; feed conversion ratio 2·0). Low dietary lipid levels ( < 12 %) significantly improved nutrient retention and gain and hence growth, without major effects on whole-body composition. Despite the slight alteration in n-3 PUFA muscle content in the fish fed low-fat-diets, this fish fed low dietary lipid still remains a rich n-3 PUFA product and generally maintained its nutritional value. These results evidenced a low lipid tolerance of Senegalese sole juveniles and suggest a maximal dietary inclusion level of 8 % lipids for both optimal growth and nutrient utilisation without compromising flesh quality.