Miracle-dz/UniFAR-FTUs huggingface dataset:
Community assembly processes restrict the capacity for genetic adaptation under climate change

Given the magnitude and rate of ongoing climate change, the physiological capacity of species to tolerate extreme conditions will play a key role in influencing outcomes for biodiversity. It is also possible that species will respond to changes in climate by shifting their physiological tolerances, through genetic adaptation. How these processes influence biodiversity outcomes will be crucial in determining the most suitable management responses to retain diversity into the future. Here we assess how accounting for physiological tolerances, genetic adaptation and community assembly processes such as species replacement, influence projected climate change outcomes for the flora of Tasmania (all 2051 plant species). We incorporate these processes into the M‐SET metacommunity model and compare four different assumptions of species niches: realized niches, broader physiological tolerances and low or high capacity for genetic adaptation. Accounting for physiological tolerances rather than realized niches had the largest impact on projected outcomes, with 358 fewer species extinctions in the hottest climate scenario (mean = 30 extinctions). In contrast, adding the capacity for species physiological tolerances to shift through genetic adaptation resulted in little additional benefits for biodiversity outcomes, even under an optimistic level of adaptive capacity. We find that this is due largely to community assembly processes such as species replacement restricting the ability of species to persist and adapt in situ, as has been suggested from theoretical metacommunity models applied in simple artificial settings. Our results highlight the importance of accounting for species physiological tolerances and community‐level processes in biodiversity projections, while the potential role for genetic adaptation may be small, requiring further exploration in alternative contexts.
Evaluation of the nutritive value of soluble coffee.

The European Union is considering to making nutritive labeling mandatory for all food, including coffee. Food legislation has defined methodologies to evaluate nutritive values, which are not adapted to roasted products such as coffee. The evaluation of the energy value and dietary fibers were revisited for soluble coffee. The energy value of soluble coffee should be determined from its detailed composition. Applying this approach, soluble coffee provides 67 kCal/100 g powder compared to the 350 kCal/100 g established with the official method. This difference is due to a systematic over-evaluation of the protein and carbohydrate contents in soluble coffee with the official method. The nutritive value is fairly independent of the blend characteristics but increases for soluble coffee obtained from severe extraction processes (e.g. 98 kCal/100 g). The contribution of soluble coffee to the energy balance of a diet is minute, i.e. ~1 kCal/cup brought by 0.1 g of proteins and < 0.2 g of carbohydrates. However, soluble coffee is an important source of soluble dietary fibers (mannans, arabinogalactans), i.e. ~30%, which correspond to 0.6 g/cup of fibers. The possible contribution of melanoidins to dietary fibers needs further clarification.
Advances in gene therapy for hemophilia

Hemophilia gene therapy is the process that vectors transfer normal FⅧ and FⅨ gene into patients with hemophilia, in order to correct genetic defects and produce normal FⅧ and FⅨ protein, which can meet the hemostatic requirements and bring new hope for treatment of hemophilia.The transformation of the target gene, as well as how to choose vectors and target cells are important parts of this process. The core technology of hemophilia gene therapy is gene transfer vector technology, and vectors for gene therapy can be divided into non-viral vectors and viral vectors.At present, many researches of gene therapy for hemophilia have made a breakthrough progress. However, hemophilia gene therapy still have some problems, such as the application of the vectors, the selection of target cells, the immune response to the vectors and the expression products, and the like, so further researchs are still needed. Therefore, this article summarizes the gene therapy process and clinical research progress of hemophilia. Key words: Hemophilia; Gene therapy; Genetic vectors; Targeted gene repair
3D Point Cloud Descriptors in Hand-crafted and Deep Learning Age: State-of-the-Art.

The introduction of inexpensive 3D data acquisition devices has promisingly facilitated the wide availability and popularity of 3D point cloud, which attracts more attention to the effective extraction of novel 3D point cloud descriptors for accuracy of the efficiency of 3D computer vision tasks in recent years. However, how to develop discriminative and robust feature descriptors from 3D point cloud remains a challenging task due to their intrinsic characteristics. In this paper, we give a comprehensively insightful investigation of the existing 3D point cloud descriptors. These methods can principally be divided into two categories according to the advancement of descriptors: hand-crafted based and deep learning-based apporaches, which will be further discussed from the perspective of elaborate classification, their advantages, and limitations. Finally, we present the future research direction of the extraction of 3D point cloud descriptors.
Support Vector Machine for Classifying the Quality of the Egg based on the Color

: Egg quality is an indicator to determine the freshness of an egg. One of a method to determine the egg quality is through an analysis of eggshell condition. Color intensity of the eggshell comprises of three classes, i.e. dark-brown, brown, and light-brown colors. This classification is based on the pigment concentration and the structure of eggshell. Dark brown egg stronger and thicker than the light brown one. The quality of an egg decreases faster for bright eggshell’s color. This research classified the quality of broiler eggs based on the eggshell color using the support vector machine. This research used color red-green-blue (RGB) image of ninety eggs sample. Feature extraction was used to calculate the RGB of each egg. Normalization was used to get normalize RGB parameters (rgb) before classification through the use of support vector machine. Classification result showed the accuracy of 80 percent.
Psychological vulnerability as an integral component of comprehensive vulnerability assessment: informing policy and practice in disaster risk reduction

Science can be utilised to mitigate risk and vulnerability throughout the disaster management cycle. The risk of a disaster depends not only on the hazard but also on the psychological, social and environmental vulnerability of exposed communities. Through a review of existing knowledge on evidence-based methods for assessing vulnerability in communities, it was found that psychological vulnerability is seldom considered in such assessments. We argue that psychological aspects play a key role in how people and communities perceive and respond to disaster events. Building infrastructure to assess vulnerability in a comprehensive manner is essential to inform policy and practice in disaster risk reduction. Better understanding of these complex relationships and the role of psychological vulnerability in reducing risk and building the resilience of nations and communities to disasters requires interdisciplinary approaches cutting across fields such as science, psychology, health, environment, economics, engineering and technology.
Caractérisation cellulaire et moléculaire de l'activité de dérivés de 2-aryl-3-quinolone, une famille de petites molécules antagonistes de la queue cytoplasmique des intégrines

Les flavonoides sont etudies depuis des annees pour leurs proprietes preventives et leur potentiel comme agents therapeutiques. Plusieurs mecanismes pourraient intervenir dans leur activite anti-cancereuse dont une inhibition de l'adherence et de l'etalement cellulaire et une inhibition des proprietes invasives des cellules cancereuses. Les derives de 3-aryl-2-quinolones sont structurellement proches des flavonoides et ont ete caracterises comme etant des composes anti-migratoires (Joseph et Al., J.Med.Chem, 2002). Comme la migration cellulaire est hautement dependante des structures adhesives assemblees par la cellule, nous avons etudie l'activite de ces composes sur les adherences focales et fibrillaires. Ces larges complexes proteiques impliquent notamment les integrines et leurs partenaires cytoplasmiques les liant au cytosquelette. Les integrines permettent a la cellule de percevoir son microenvironnement et de s'y adapter. Les structures d'adherence contenant les integrines sont en retour capables de controler cet environnement (degradation matricielle, fibrillogenese…). Nos travaux montrent que les derives de 3-aryl-2-quinolone sont capables d'inhiber l'etalement cellulaire et de provoquer le desassemblage de structures adhesives prealablement etablies de facon dose-dependante et independamment de la composition de la matrice extracellulaire. L'activite des composes est finement liee a leur structure et de legeres modifications de la composition chimique de leur chaine laterale peuvent inhiber leur activite. Nous avons pu etablir une relation structure-activite pour cette famille de composes et avons etudie les mecanismes moleculaires menant au desassemblage des structures d'adherences quand les cellules sont traitees par ces molecules. Des etudes par RMN ont montre une interaction directe entre le chef de file de cette famille de composes et le domaine cytoplasmique des integrines a chaine beta 3 et nous avons pu montrer que cette interaction inhibait la liaison sur l'integrine de l'un de ces activateurs, la kindline. L'agregation plaquettaire est dependante de l'activation des integrines et constitue un excellent systeme d'etude physiologique pour les inhibiteurs de ces recepteurs. Le chef de file des derives de 3-aryl-2-quinolone est capable d'inhiber l'agregation plaquettaire et la formation du thrombus, ce qui en fait un bon candidat medicament comme anti-thrombotique.
Examine the Role of Family Environment to the Development of Psychological Resilience among Urban and Rural Adolescents

The present study examined the role of family environment to the development of psychological resilience among urban and rural adolescents. The sample consisted of 120 adolescents were selected for the study which includes 60 urban and 60 rural from Kolhapur districts. Random sampling method was used for the data collection. Resilience was measured by Adolescent Resilience Questionnaire (Deirdre Gartland, 2006) and family environment was measured by Family Environment Scale (Bhatia and Chadha, 1993). The Method of central tendency was used for data analysis and computes the Mean, SD and calculated ‘r’ and ‘t’ values. The results indicated that the there is a positive correlation between resilience and family environment among urban and rural adolescents. Whereas the mean score of rural adolescents is more than urban adolescent with respect to resilience and family environment, it’s showed that the level of resilience and family environment among rural living adolescents is higher than that of urban living adolescents. The findings also indicated that there is no significant difference found between resilience and family environment among urban and rural living adolescents.
Automatic Summary System for Patients Hematological Examination Result in Textual Representation Form

: Results of hematological examination from a laboratory are presented in the form of medical abbreviations and numbers alongside their units, which are represented in tabular form. The result of laboratory examination is not provided with explanation text on whether the blood components of the hematologic examination results are normal, abnormal or critical. In order to analyze the blood components of a hematological examination, a physician should manually compare each blood component value with the known normal range of values available. In this research Natural Language Generation (NLG) with a template-based method is employed to interpret the results of the patient’s hematology laboratory examination. The result of interpretation is written into a summary text in Bahasa Indonesia. Evaluation of the naturalness of the summary text obtained from the system performed by general practitioners and young doctors reported higher percentage interval of 93.1% to 97.5%.
High Central Venous Pressure Associated with Mortality in ICU

: Background : For decades Central venous pressure (CVP) has often been used as a measurement of hemodynamics, medication and nutrition for critical patients. In Intensive care unit (ICU) we use APACHE or SOFA score for prediction of mortality. We need a lot of time and procedure to get the prediction. Not every hospital can apply this APACHE and SOFA in their hospital. Since CVP is widely use in ICU for monitoring, we can use the value of CVP as predictor mortality. Method : A retrospective study conducted at H Adam Malik Hospital in Medan. Samples are taken by recording CVP in ICU patients. Patients who have a high CVP (> 8 mmHg) are recorded and seen whether the patient dies or can leave the ICU. Result : During the study period, 100 patients were admitted. 52% were male with mean age 48.5±16.5 years old. The overall mortality of 100 patients was 38%. There was association between high central venous pressure with mortality in ICU (p=0.004). There is a significant relationship between high CVP and mortality. Conclusion : High CVP is associated with mortality rates.
Handbook of Microwave Technology for Food Application

Part 1 Fundamental physical aspects of microwave absorption and heating: electromagnetics - fundamental aspects and numerical modelling electromagnetics of microwave heating - magnitude and uniformity of energy absorption in an oven dielectric properties of food materials and electric field interactions fundamentals of heat and moisture transport for microwavable food product and process development. Part 2 Chemical and biological changes due to heating: generation and release of food aromas under microwave heating bacterial destruction and enzyme inactivation during microwave heating. Part 3 Processing systems and instrumentation: consumer, commercial and industrial microwave ovens and heating systems measurement and instrumentation. Part 4 Processes at industry and home: microwave processes for the food industry basic principles for using a home microwave oven. Part 5 Product and process development: ingredient interactions in microwave heating packaging techniques for microwavable foods. Part 6 Safety: safety in microwave processing.
Rôle de Scribble1 dans la formation des synapses glutamatergiques et le trafic des récepteurs NMDA

Les neurones etablissent entre eux de nombreux contacts synaptiques, et l'on estime qu’en moyenne un neurone peut avoir dix mille contacts avec les neurones de son voisinage. L'une des synapses les plus importantes et les plus etudiees, dont les dysfonctionnements conduisent a des pathologies du cerveau, est la synapse excitatrice glutamatergique. Dans l’hippocampe, les synapses excitatrices presentent une structure postsynaptique particuliere, sous la forme d’un renflement de la dendrite appele epine dendritique. Cette epine possede un domaine particulier, la densite postsynaptique, concentrant de nombreux recepteurs aux glutamates, des proteines d’adhesion ainsi que des proteines d’echafaudage faisant le lien avec les cascades moleculaires intracellulaires et le cytosquelette d’actine. La morphologie de l’epine dendritique ainsi que le nombre de recepteurs presents dans la PSD sont des elements cles dans la transmission synaptique et les phenomenes de potentiation et de depression a long terme (LTP & LTD). Lors de ma these, j’ai identifie Scribble1 comme une nouvelle proteine regulant le trafic des recepteurs NMDA. Scribble1 est surtout connue pour son implication dans des processus de polarite, division et migration cellulaire. En modulant le taux de Scribble1, j’ai montre que je pouvais affecter le nombre et la morphologie des epines des neurones hippocampaux, ainsi que la polymerisation de l’actine. Ensuite, j’ai demontre que Scribble1 interagissait directement avec les recepteurs NMDA et permettait leur recyclage a la membrane. Enfin, chez le neurone immature, Scribble1 est implique dans la migration du cone axonal. Chez un animal mutant, qui n’exprime que 50% de la proteine (circletail) les performances mnesiques et sociales de l’animal sont perturbees, validant le role de la proteine au niveau du systeme nerveux.
HPV Meets APOBEC: New Players in Head and Neck Cancer

Besides smoking and alcohol, human papillomavirus (HPV) is a factor promoting head and neck squamous cell carcinoma (HNSCC). In some human tumors, including HNSCC, a number of mutations are caused by aberrantly activated DNA-modifying enzymes, such as the apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) family of cytidine deaminases. As the enzymatic activity of APOBEC proteins contributes to the innate immune response to viruses, including HPV, the role of APOBEC proteins in HPV-driven head and neck carcinogenesis has recently gained increasing attention. Ongoing research efforts take the cue from two key observations: (1) APOBEC expression depends on HPV infection status in HNSCC; and (2) APOBEC activity plays a major role in HPV-positive HNSCC mutagenesis. This review focuses on recent advances on the role of APOBEC proteins in HPV-positive vs. HPV-negative HNSCC.
BENEFICIARIES’ ATTITUDE TOWARDS PRODUCTIVE SAFETY NET PROGRAM IN SELECTED RURAL KEBELES OF EBINAT WOREDA, NORTHWEST ETHIOPIA

The Ethiopian Productive Safety Net Program (PSNP) is the biggest social protection schema in Sub-Saharan Africa as Ethiopia has remained the largest recipient of food aid. This paper examined the attitude of beneficiary households towards PSNP in selected kebeles of Ebinat woreda by using mixed research methods. In-depth interview, focus group discussions and questionnaire survey were used to collect the data while Likert Rating Scale and thematic analysis were employed to analyze and interpret the data. The result shows that the majorities of respondents have a strong feeling of dependency about the program itself and are keenly aware of how PSNP is important to them. However, they have a negative attitude towards the services they are gaining from PSNP and its implementation process. Specifically, the amount of cash, working time, school access to children, livestock accumulation and availability of food were found to be the lowest. Although the beneficiary households are extremely dependent on PSNP’s aid, the majority of them still complain about its services. Therefore, awareness has to be created to break their strong dependency and attachment towards aid by empowering them to search for sustainable and alternative livelihood strategies.
Ecological niche modeling of invasive alien plant species in a protected landscape

Non-native plants that can cause adverse effects are otherwise known as invasive alien plant species which pose a major threat to plant biodiversity conservation and sustainability. This study is dedicated to determine the plant diversity and to assess the vulnerability of Quezon Protected Landscape, Southern Luzon, the Philippines to invasive alien plant species. Data from 90 10x10 m randomly established plots using the quadrat method showed that there are 318 plant species wherein 208 are native, 100 are non-native, and 10 are invasive. Results from the association of the physicochemical factors and the presence of invasive alien plant species through Spearman rho test revealed that most of the physicochemical factors have significant association except percent slope and hill shade. Soil pH, aspect and number of non-native plants show positive association while soil moisture, leaf litter thickness, elevation, species richness, species evenness, plot species diversity index, and the number of native plants signify negative association. Differences between the plots of with and without invasive alien plant species in physicochemical factors indicate that most of the physicochemical factors have a significant difference between plots of with and without invasive alien plant species except percent slope, hill shade, and aspect. Lastly, the MaxEnt model exemplifies that the most suitable predicted conditions for invasive alien plant species are at the edges of boundary and buffer zones. This study implies that most of the physicochemical factors are linked to the presence of invasive alien plant species and Quezon Protected Landscape has a low vulnerability to invasive alien plant species invasion.
Incentive or obstacle? The use of parental leave of immigrant mothers

Introduction Like in in many other countries the labour market situation of the foreign-born population in Sweden is worse than for the native-born population. The employment rates are about 10 per cent lower for immigrant men and about 20 per cent lower for immigrant women as compared to their Swedish-born counterparts with a considerably variation by country of origin and time since immigration (Statistics Sweden 2008). At the same time Sweden is a universalistic welfare state with social policies directed towards parents without any distinction by citizenship. The parental-leave insurance consists of benefits based on prior earnings or a flat rate for parents who were not active in the labour market before becoming parents. It is 16 months long per child and it can be used flexibly up to the child is 8 years old (Duvander 2010). The parental leave benefits, like family benefits, are based on residency. As the leave can be used up until the child is 8 years old, this means that newly arrived immigrant parents can get access to leave benefit when they register with the Swedish Social Insurance Agency. Thus, leave benefits may in these cases be used more often for somewhat older children, implying that the children do not go to day care and the parent (most often the mother) stay out of the labour market. With this paper we want contribute to the debate on the effects of a generous parental leave as well as the welfare state’s strategy to speed up the integration process for newly arrived immigrants. Several studies have already shown the positive correlation between parental leave policies and fertility (Lalive and Zweimuller 2009) and between family policies (job protection, parental leave benefits) and women’s labour market returns after childbearing (Ruhm, 1998). However, the same policies may create incentives to stay out of the labour force for specific groups (Olli Segendorf and Telijosuo 2011, Vikman 2013). Researchers focusing on immigrant assimilation in United States (Chiswick 1978, Borjas 1985, 1989) or in Europe (Clark and Drinkwater 2002, Helgertz 2010) already concluded that during the first years in a host country, immigrants have lower employment rates and lower earnings, and also few reach the participation or occupational position of native-born. According
The Symmetry of My Life: An Autobiographical Visualization

I present an autobiographical visualization of the past 18 months of my life that shows work and personal activities, steps, floors, emails, SVN commits, and contextual annotations. The spiral layout makes both cyclical and symmetrical patterns emerge. The resulting autobiographical visualization makes it possible to both reminisce and share personal stories.