Miracle-dz/UniFAR-FTUs huggingface dataset:
How to win the ovarian cancer stem cell battle: destroying the roots

Ovarian cancer has the highest mortality rate among gynecologic malignancies. The combination of cytoreductive surgery and chemotherapy is the standard regimen for the treatment of ovarian cancer. The initial treatment is usually effective, but many patients with ovarian cancer experience recurrence, and treatment options for recurrent disease remain challenging. Cancer stem cells (CSCs) are suggested to play an essential role in cancer recurrence after initial chemotherapy. Furthermore, they are of great interest as CSCs may also be involved in chemotherapy susceptibility. Thus, understanding the characteristics and mechanisms by which CSCs display resistance to therapeutic agents is important to design effective cancer treatments. In this review, we describe and discuss current therapeutic regimens for ovarian cancer, as well as the various CSC markers, association between CSCs and disease progression, correlation of CSCs with poor prognosis, enrichment of CSCs in tumor tissues following repeated chemotherapy cycles, activation of major signaling pathways following chemotherapy, and potential inhibitors that suppress these signaling cascades. In addition, clinical trials evaluating novel targeted therapies to overcome chemotherapy resistance will be reviewed. The combination of traditional chemotherapy and CSC-targeted therapy could be an effective and promising anticancer treatment for ovarian cancer. Understanding the biological properties of CSCs and the mechanism of chemotherapy resistance are critical to design and develop new therapeutic strategies to overcome CSC-associated chemotherapy resistance.
A community based study on type 2 diabetes mellitus in a rural field practice area of katuri medical college, Guntur

Background & Objectives: India is on its march towards having the most number of diabetics worldwide and is aptly called the „diabetic capital‟ of the world. Limited information on the problem of diabetes in rural area has necessitated the need for this study to find the prevalence of type 2 diabetes mellitus and the risk factors associated with it along with the compliance in known diabetics. Methods: A cross sectional study was conducted was conducted in Guntur, a rural field practice area of Katuri Medical College, Guntur during 1 st January 2017 to 31 st October 2018. A quick enumeration survey was done to identify the 6,992 participants aged 20 years and above of whom a sample of 1364 respondents were selected by systematic random sampling and were evaluated for diabetes, its risk factors and compliance. Results: Present study revealed the prevalence of diabetes as 6.52%. Diabetes was found to be significantly associated with increasing age in both the genders, in employed respondents, vegetarians, smokers, positive family history of diabetes, higher BMI, central obesity and among hypertensives. Only 39.76% diabetics knew their diabetic status and the overall compliance of diabetes were found to be 13.48%. Interpretation & Conclusion: Higher prevalence of diabetes similar to Indian average found in this village along with very poor compliance of diabetes is a matter of concern and has to be addressed in this economically backward villages of rural area by regular screening and motivation to modify the risk factors responsible and improve the compliance to reduce the possible complications of the disease.
Cuáles son los significados de la sexualidad en jóvenes universitarios

El objetivo del presente trabajo fue describir el significado que atribuyen los universitarios a diferentes frases relacionadas con la sexualidad, ya que los jovenes atraviesan por cambios psicologicos y sociales propios de la etapa de desarrollo, lo que puede derivar en conductas sexuales riesgosas, las cuales son solapadas por el contexto universitario. El muestreo fue no probabilistico y participaron 171 estudiantes de nivel superior. Se utilizo la tecnica de Redes Semanticas Naturales Modificadas con los siguientes estimulos: “metodos anticonceptivos”, “abstinencia”, “primera relacion sexual”, “condon” y “beneficios del sexo”. Los resultados muestran significados con connotacion positiva y orientados hacia la prevencion en los diferentes estimulos; pero tambien, atribuyen significados con valoracion negativa, los cuales se encuentran matizados por las creencias de genero.
Work In Progress: Control-Flow Migration for Data-Locality Optimisation in Multi-Core Real-Time Systems

Multi-core real-time systems face the challenge of efficiently maintaining consistency of shared data despite concurrent operations. Existing synchronisation techniques ignore data locality, resulting in cache-related execution time overheads. This paper proposes Migration-Based Synchronisation (MBS), a transparent replacement for locks. In MBS, control flows are migrated to data, instead of moving data to control flows. The consequence is an improvement of data locality that reduces the worst-case execution time of critical sections, and indirectly, worst-case blocking bounds.
Weed composition and control in apple orchards under intensive and extensive floor management

Weed control in apple tree (Malus domestica [Suckow] Borkh.) orchards continues to be a major problem. Weeds compete with fruit trees, which is manifested in production quality and quantity. The aim of this study was to determine the weed flora of apple orchards with different floor management practices and to investigate the efficacy of the diquat, oxyfluorfen, glyphosate, and fluazifop-P-butyl herbicides. Experiments were conducted during 2015 and 2016 in orchards under intensive (Ruski Krstur) and extensive (Sombor) floor management. Annual, perennial broad-leaf, and grass weeds were identified. Dominant weed species in both apple orchards were Poa annua, Hordeum murinum, Conyza canadensis, Portulaca oleracea, Cynodon dactylon, Sorghum halepense, Carduus acanthoides, Amaranthus retroflexus, Cirsium arvense, Chenopodium album, and Solanum nigrum. After the first and second assessments, the best results occurred with glyphosate in both orchards and total efficacy ranged from 88.42% to 98.32% in the orchard under intensive floor management and 90.32% to 95.55% in the orchard under extensive floor management. Diquat and oxyfluorfen have shown good results, but their efficacy was lower than for glyphosate. Fluazifop-P-butyl, as a selective herbicide, showed low efficacy at both sites; it had high efficacy on grass weeds, but no effects on broad-leaf weeds.
Contraceptive usage among undergraduate female students: A survey sampling approach

In this paper, a survey sampling on contraceptive usage among the female undergraduates of Federal University of Technology, Akure using the randomized response technique proposed by Warner was extensively carried out. The data for the study was obtained from the administration of well-structured survey questionnaires on respondents from three different schools in the University. Consequently, the estimated Warner’s proportions of female undergraduate students who used contraceptives and their resulting variances were evaluated at varying sample sizes and predetermined probabilities 𝑃 respectively. The results as presented in the summary table 10 revealed that contraceptive usage was at maximum level for School of Agriculture and Agricultural Technology as sample sizes varied.
The Politics of Indigeneity and Heritage

This article contributes to comparative museology by examining curation practices and politics in several “museum-like” heritage spaces and locally run museums. I argue that, in this era of heritage consciousness, these spaces serve as creative stages for advancing potentially empowering narratives of indigeneity and ethnic authority. Understanding practices in ancestral spaces as “heritage management” both enriches our conception of museums and fosters nuanced understandings of clashes unfolding in these spaces as they become entwined with tourism, heritage commodification, illicit antiquities markets, and UNESCO. Drawing on ethnographic research in Indonesia, I update my earlier work on Toraja (Sulawesi) museum-mindedness and family-run museums, and analyze the cultural politics underlying the founding of a new regional Toraja museum. I also examine the complex cultural, religious, and political challenges entailed in efforts to repatriate stolen effigies (tau-tau) and grave materials, suggesting that these materials be envisioned as “homeless heritage” rather than “orphan art.”
Energy Harvesting from Machineries for Industries: Vibration as a source of energy

Arising the value of new technologies each day and raising the human population, demands more power to use appliances in day to day life. Internet of Things (IoT) application is a modernized innovative technology that connects objects and embedded devices for instance smart devices with sensors and actuators. In several IoT applications longer lifespan, scalability, maintenance free and mobility support of the devices is of prominent need. A feasible solution is to scavenge and harvest energy from vibrations present in the environment. Therefore, focusing on Piezo Energy Harvesting (PEH) from vibrations will be a promising solution to power IoT devices. To support new technologies with power it requires very less energy and it can be harvested from scavenging energy present in our environment. The best means of scavenging energy can be from vibrations. Power generation can be done in a number of ways using different techniques. We are proposing a new renewable way of generating electrical energy from the unused vibrations present in the environment. Moreover, piezoelectric energy harvesting technique has become favored among researchers because of the simplicity of converting mechanical energy into electric energy using piezoelectric transducers. Thus focusing on the piezoelectric energy harvesting, we provide a promising solution to power the sensor nodes present in the industries. Therefore without any consumption of fuel or any usage of non-renewable resources, electrical power can be viably generated from unused vibrations.
Towards Accuracy: A Model for the Analysis of Typographical Errors in Specialised Bilingual Dictionaries. Two Case Studies

This paper presents the results of research on typographical error analysis in two specialised bilingual paper dictionaries: Diccionario de terminos economicos, financieros y comerciales/ A Dictionary of Economic, Financial and Commercial Terms ( Ariel, 2012), and Diccionario de terminos juri dicos/A Dictionary of Legal Terms ( Ariel, 2012). A model of errors is described, including similar errors and errors that are repeated both intratextually and intertextually. The error frequency in A Dictionary of Economic, Financial and Commercial Terms is higher than the average error frequency in a reference corpus of fourteen dictionaries (mainly first editions). This indicates that repeated editions do not always guarantee a higher level of formal correctness. Our results also show that a high frequency of errors does not necessarily entail a high intratextual error repetition rate. On the other hand, we establish a relationship between typographical errors and the access function in dictionaries, as that kind of error can interfere with access to accurate lexicographical information and data retrieval (especially when they occur in lemmas or sublemmas).
Optimization of a Mobile Phase for Monitoring Strontium in Seawater Using Non‐suppressed Ion Chromatography

Abstract A non‐suppressed ion chromatographic (IC) method has been developed for the monitoring of strontium in the presence of a large excess of alkali and alkaline earths. The mobile phase consisting of ethylenediamine (EDA) and organic acid as a complexing agent has been optimized in combination with a high‐speed cationic column. The reported method has been tested, successfully, to monitor strontium in coastal Arabian seawater with a coefficient of variation 2 (n = 5). The reported results have been compared with ICP‐OES analysis and are in agreement.
Economic Well-Being of Low-Income Single-Mother Families: A Review Paper

This study is to explore the changes in net disposable income for low-income single-mother families before and after the 1996 welfare reform in the USA. Even though there are many studies have made on welfare reform but it all have focused on employment or the total family income as a way to measure low-income single-mother families’ economic well-being little is known about their net income after expenses related to entering the workforce. Participation conducted by the US Census Bureau. The results revealed that while low-income single mothers were working more after welfare reform, their net disposable income decreased during this time because their earnings were low and offset by an increase in childcare costs and a decline in means-tested benefits, including Temporary Assistance for Needy Families benefits.
COVID-19 Online Teaching and its Impact on Psychological Health in Higher Education: A Cross Sectional Study on Medical Students of 1st 2nd and 3rd Year MBBS

Background: Covid-19 emerged from Wuhan; China in December 2019 took the whole world in its grip in mere few months the cases were found in almost every part of the globe. Pakistan too, was severely impacted tolling 233,500 cases of the coronavirus and 6,035 deaths to date. Most of the schools and colleges resorted to an online educational platform in order to resume work and discipline in life during such chaos, perhaps the most affected were the professionals of healthcare setup including medical students who reported to have far higher rates of depression than the average person. Objectives: To examine the association of COVID-19 to the prevalence of depression, anxiety, or stress amongst medical students of 1st, 2nd, and 3rd year MBBS in this quarantine period and their attitude towards online classes. Methodology: It was a cross sectional study conducted in Clifton campus of Ziauddin University Karachi in the month of May 2020. Medical students studying in 1st, 2nd, and 3rd year MBBS were included in the study. The total calculated sample size was n=105, Non-probability Consecutive sampling technique was used to recruit the participants. Depression, anxiety, and stress scale (DASS) was used to assess psychological health among study participants. Results: DASS score showed that Stress and anxiety were significantly (p=0.001) prevalent in students however there are no significant findings observed related to depression, many responded that their life routine is altered and their attitude towards online session was significantly positive. Conclusion: Stress and anxiety was found to be prevalent in in Medical students predominantly in students studying in 1st year MBBS, their life routine is disturbed and their attitude towards online classes was welcoming.
Characterization of Used and Fresh Hydraulic Oils of Heavy Machinery Plants. Simple Treatment Methodology and Characterization of Treated Oil

Fresh and used hydraulic oil samples were characterized. Density, kinematic viscosity, pour point, flash point, rust prevention, total acid number, oxidation stability, thermal stability, foam characteristics, foaming tendency, water content, and particle count were assessed for both fresh and used oil samples. Results show that water content has considerably affected most of the oil properties. The used oil sample failed the appearance, thermal stability, oxidation stability, foaming tendency, water content, and particle count. Simple treatment methodology was adopted, involving settling, dry-air bubbling, and vacuum filtration. Treated oil sample passed the tests of appearance, water content, particle count, and thermal stability.
Effects of meteorological parameters on RSPM concentration in urban Delhi

The adverse effect of Respirable Suspended Particulate Matter (RSPM) has become a well-recognised problem in environmental science. Dispersion and dilution of air pollutants are strongly influenced by meteorological parameters, namely wind, turbulence, and atmospheric stability. The analysis of Delhi's air quality data shows that winter is the most critical season with respect to the concentrations of particulates matter and monsoon is the cleanest. In the present work a stepwise regression technique has been used for predicting the concentration of RSPM in urban Delhi. The models' performance has been further improved by taking a new independent variable i.e., the previous day's concentration, in addition to the meteorological parameters.
DISTURBANCE INFLUENCES ON PINE TRAITS IN THE SOUTHEASTERN UNITED STATES

Traits of southeastern pines (Pinus spp.) were analyzed in relation to presetdement disturbance regimes infer:red from the literature. Inferred regimes suggest minimal fire influence in the mesic class plus a trend of increasing frequency/decreasing intensity in the order of xeric hill, low shrubland, transition, and savannah pine classes. Changes among species in wood density and taproot development imply greater wind resistance with greater forest openness due to the relative influence of fire. As burn frequency increases there also is greater needle length, resin content and bark insulation, in contrast to less reproductive output, persistence of foliage, and crown density. Tree height and longevity may have been modified directly by disturbances, or indirectly as a consequence of emphasis on other energy-demanding traits. Combinations of traits suggest five primary adaptive modes: (1) persistence of savannah pines through spread of frequent fires (via longer needles, more resin) which repel competing species, plus conservative investment in robust seedlings with delayed height growth and protection from fire; (2) compromise (between defense and growth) within transitions where both fire regime and hardwood competition are moderate-periodic; (3) resilience within shrublands of sparse trees through sprouting between occasional intense fires, aided by early sexual maturity; (4) saturation of dry hills through episodic regeneration and vertical fuel accumulation which leads to stand-replacing fires; and (5) preemption of space through lateral (root-limb) and height growth on hardwood-dominated sites where pine success hinges upon various disturbances to open sites. Disturbance influences seem not to be limited to selection for defenses, but may include selection of traits that actually promote disturbance, thereby improving fitness of pines . Climatic periods with frequent lightning under warm-moist conditions likely favored many firedependent plants with traits that tend to increase the probability of appropriate fire regimes.
MULTIFACETED POTENTIAL OF EICHHORNIA CRASSIPES (WATER HYACINTH) LADENED WITH NUMEROUS VALUE AIDED AND THERAPEUTIC PROPERTIES

Being an aquatic weed which is growing dense and widespread across many lakes and water bodies, it is of paramount importance to utilize Eichhornia crassipes (commonly known as water hyacinth) for the benefit of the mankind, especially for its value added and medical properties, such as bio-fuel, biogas, bioremediation and therapeutics. Many of the bird sanctuaries and water-bodies have been drastically invaded by this aquatic weed which is really affecting ecological niche and bird migrations. Several researchers have successfully demonstrated the use of water hyacinth in the bio-remediation and as a potential source of renewable energy. Different heavy and toxic metals showing biomagnifications and therefore creating health hazards, could be remediated by using water hyacinth. The process of decontaminating agro-industrial waste polluted with heavy metals, organic and inorganic pollutants could possibly be done using water hyacinth. Current review focuses towards the efforts to utilize this weed for different value added and therapeutic properties. Furthermore the article emphasizes upon the need to gain more insight into the mechanism with concrete randomized controlled studies to find out the effects of this weed on human health and a sustainable solution to exploit and manage this invasive otherwise harmful weed into a beneficial entity for the mankind.
A Hybrid Travel Recommender System for Group Tourists

Travel recommender systems (TRSs) are developed as information filtering tools to provide travel decision-making support. They make personalised recommendations based on the user’s preferences. People tend to make group travel decisions based on trip-specific motivations. The current Group Travel Recommender Systems (GTRSs) exploit individual user’s preferences and make group recommendations by aggregating profiles or aggregating recommendations. Although aggregation is a straightforward way to combine the preferences of different group members, it has been critiqued on overlooking of the group dynamics. Interaction needs among tourists’ have a great influence on group travel preference. This proposed study explores a conceptual framework for a hybrid group travel recommender system based on this consideration
Bioinformatic Analysis Linking Genomic Defects to Chemosensitivity and Mechanism of Action

A joint analysis of NCI60 small molecule screening data, their genetically defective genes and mechanisms of action (MOA) of FDA approved cancer drugs screened in the NCI60 is proposed for identifying links between chemosensitivity, genomic defects and MOA. Self-organizing-maps (SOMs) are used to organize the chemosensitivity data. Student’s t-tests are used to identify SOM clusters with chemosensitivity for tumor cells harboring genetically defective genes. Fisher’s exact tests are used to reveal instances where defective gene to chemosensitivity associations have enriched MOAs. The results of this analysis find a relatively small set of defective genes, inclusive of ABL1, AXL, BRAF, CDC25A, CDKN2A, IGF1R, KRAS, MECOM, MMP1, MYC, NOTCH1, NRAS, PIK3CG, PTK2, RPTOR, SPTBN1, STAT2, TNKS and ZHX2, as possible candidates for roles in chemosensitivity for compound MOAs that target primarily, but not exclusively, kinases, nucleic acid synthesis, protein synthesis, apoptosis and tubulin. This analysis may contribute towards the goals of cancer drug discovery, development decision making, and explanation of mechanisms.
Bell-shaped dose response for a system with no IFFLs

It is well known that the presence of an incoherent feedforward loop (IFFL) in a network may give rise to a steady state non-monotonic dose response. This note shows that the converse implication does not hold. It gives an example of a three-dimensional system that has no minmail-paths IFFLs, yet its dose response is bell-shaped. It also studies under what conditions the result is true for two-dimensional systems, in the process recovering, in far more generality, a result given in the T-cell activation literature.