Miracle-dz/UniFAR-FTUs huggingface dataset:
An exploratory study about meaningful work in acute care nursing.

OBJECTIVE To develop deeper understandings about nurses' perceptions of meaningful work and the contextual factors that impact finding meaning in work. BACKGROUND Much has been written about nurses' job satisfaction and the impact on quality of health care. However, scant qualitative evidence exists regarding nurses' perceptions of meaningful work and how factors in the work environment influence their perceptions. The literature reveals links among work satisfaction, retention, quality of care, and meaningfulness in work. METHODS Using a narrative design, researchers interviewed 13 public health nurses and 13 acute care nurses. Categorical-content analysis with Atlas.ti data management software was conducted separately for each group of nurses. This article reports results for acute care nurses. RESULTS Twenty-four stories of meaningful moments were analyzed and categorized. Three primary themes of meaningful work emerged: connections, contributions, and recognition. Participants described learning-focused environment, teamwork, constructive management, and time with patients as facilitators of meaningfulness and task-focused environment, stressful relationships, and divisive management as barriers. Meaningful nursing roles were advocate, catalyst and guide, and caring presence. CONCLUSIONS Nurse administrators are the key to improving quality of care by nurturing opportunities for nurses to find meaning and satisfaction in their work. Study findings provide nurse leaders with new avenues for improving work environments and job satisfaction to potentially enhance healthcare outcomes.
Rifaximin has no effect on hemodynamics in decompensated cirrhosis: A randomized, double‐blind, placebo‐controlled trial

Decompensated cirrhosis is characterized by disturbed systemic and splanchnic hemodynamics. Bacterial translocation from the gut is considered the key driver in this process. Intestinal decontamination with rifaximin may improve hemodynamics. This double‐blind, randomized, controlled trial (clinicaltrials.gov, NCT01769040) investigates the effects of rifaximin on hemodynamics, renal function, and vasoactive hormones. We randomized 54 stable outpatients with cirrhosis and ascites to rifaximin 550 mg twice a day (n = 36) or placebo twice a day (n = 18). Forty‐five patients were male, mean age 56 years (±8.4), average Child score 8.3 (±1.3), and Model for End‐Stage Liver Disease score 11.7 (±3.9). Measurements of hepatic venous pressure gradient, cardiac output, and systemic vascular resistance were made at baseline and after 4 weeks. The glomerular filtration rate and plasma renin, noradrenaline, lipopolysaccharide binding protein, troponin T, and brain natriuretic peptide levels were measured. Rifaximin had no effect on hepatic venous pressure gradient, mean 16.8 ± 3.8 mm Hg at baseline versus 16.6 ± 5.3 mm Hg at follow‐up, compared to the placebo, mean 16.4 ± 4 mm Hg at baseline versus 16.3 ± 4.4 mm Hg at follow‐up, P = 0.94. No effect was found on cardiac output, mean 6.9 ± 1.7 L/min at baseline versus 6.9 ± 2.3 L/min at follow‐up, compared to placebo, mean 6.6 ± 1.9 L/min at baseline compared to 6.5 ±2.1 L/min at follow‐up, P = 0.66. No effects on the glomerular filtration rate, P = 0.14, or vasoactive hormones were found. Subgroup analyses on patients with increased lipopolysaccharide binding protein and systemic vascular resistance below the mean (1,011 dynes × s/cm5) revealed no effect of rifaximin. Conclusion: Four weeks of treatment with rifaximin did not reduce the hepatic venous pressure gradient or improve systemic hemodynamics in patients with cirrhosis and ascites; rifaximin did not affect glomerular filtration rate or levels of vasoactive hormones. (Hepatology 2017;65:592‐603).
Capnography in the Intensive Care Unit

Recent technical innovations have made portable cap nographic monitoring systems available for intensive care unit use. Some of these systems require little tech nical expertise to operate. Capnography has several clin ically relevant applications. It may be used as a monitor of respiration (apnea monitor), of wasted ventilation, or as a reflection of arterial carbon dioxide tension. In some clinical settings, it may provide information about changes in lung perfusion or carbon dioxide produc tion. Because this technique is noninvasive and con tinuous, it offers certain advantages over intermittent arterial blood gas monitoring. The advantages and limi tations of this technique are discussed.
Dementia and driving : A survey of clinical practice in aged care assessment teams

Current clinical practice in Aged Care Assessment Teams (ACATs) in NSW and ACT regarding assessment of fitness to drive in clients with a diagnosis of dementia was examined. Of 42 ACATs with a geriatrician on staff, 38 (90.5%) responded to a telephone survey. Results showed that assessment of driver fitness is largely a medically based procedure, with functional on-road assessment of driver competence occurring in 42.1% of ACATs. Use of the Mini Mental Status Examination in determining the severity of dementia and impact on driving was common (94.7%), although such predictive ability has not been demonstrated Few ACATs (36.8%) systematically review drivers despite likely disease progression. 73.7% of ACATs reported experience of clients continuing to drive against advice. Approaches to assessment in city and rural ACATs are compared.
Good Performance of Rapid Prostate-Specific Antigen Test for Detection of Semen Exposure in Women: Implications for Qualitative Research

Background: Prostate-specific antigen (PSA) is a valid biomarker of semen exposure in women and has been used to assess reliability of self-reported sexual behavior as well as serve as a proxy measure for condom efficacy. Quantitative PSA tests are expensive and require specialized equipment. A simple, rapid, and inexpensive test for PSA would facilitate semen biomarker evaluation in a variety of research settings. This study evaluated the performance of a rapid PSA test compared with a quantitative assay to identify semen in vaginal swab specimens. Methods: We tested 581 vaginal swabs collected from 492 women participating in 2 separate research studies in Bangladesh and Zimbabwe. PSA in vaginal secretions was detected using the quantitative IMx (Abbott Laboratories) assay and the ABAcard p30 (Abacus Diagnostics) rapid immunochromatographic strip test. Results: The ABAcard test was 100% sensitive (95% confidence interval [CI], 98%–100%) and 96% specific (95% CI, 93%–97%) compared with the quantitative test in detecting >1.0 ng PSA/mL vaginal swab eluate. Rapid PSA results were semiquantitative and correlated well with PSA concentrations (&kgr; = 0.88; 95% CI, 0.85–0.90). Conclusion: Rapid PSA detection requires no instrumentation and can be performed easily and economically. Having rapid PSA results available immediately following interview provides opportunities to explore discrepancies between the objective marker of recent semen exposure and self-reported behaviors.
Ocena wyników leczenia nagłej głuchoty idiopatycznej z zastosowaniem terapii tlenem hiperbarycznym Evaluation of hyperbaric oxygen and pharmacological therapy in sudden hearing loss

Summary Treatment of idiopathic sudden hearing loss (SHL) is still a big problem for the otolaryngologists, due to the still unexplained etiopathogenesis of the illness. The aim of this study was to evaluate effectiveness of pharmacotherapy combined with the hyperbaric oxygen (HBO) in idiopathic sudden sensorineural hearing loss treatment. Patients who received HBO and medical treatment in the Department of Otolaryngology of Military Institute of Health Service and Warsaw Center for Hyperbaric Therapy and Wounds Treatment were studied. Material and methods. Nine patients, with idiopathic sudden hearing loss – patients treated in 2007 year were studied. There were 5 women and 4 men involved in our study – mean age: 41 years old. Patients with sensorineural hearing loss of minimum 15 dB at 0,25–8 kHz and tinnitus were included in the treatment group. Improvement of hearing of minimum 10 dB at 0,25–8 kHz in pure tone audiometry and decrease in the intensity of tinnitus was considered as an improvement. Results. Statistically significant difference in Pure Tone Audiometry results obtained before and after the treatment was noted in 500 Hz, 1 kHz, 2 kHz, 3 kHz, 4 kHz and 8 kHz. Statistically significant difference was noted in 500 Hz, 2 kHz, 3 kHz when treatment was started within 6 days since the acoustic trauma. No side effects of therapy were observed. Conclusions. Hyperbaric oxygen therapy is the unique method of increasing concentration of oxygen in the inner ear fluids thus facilitates the regeneration process. Hyperbaric oxygen therapy combined with steroids is an effective method of sensorineural hearing loss treatment. Important is to start the therapy quickly after hearing loss.
Abnormal tuning of the hepatic circadian metabolic rhythms in lung cancer

and elucidating the therapeutic role of pioglitazone in nondiabetic NASH patients will be essential for an effective, individualized, patient-centered approach in the near future. In the meantime, pharmacological research is developing compounds that keep the therapeutic effectiveness of pioglitazone, but are devoid of its unwanted effects, including selective peroxisome proliferatoractivated receptors (PPAR) c modulators, mitochondrial target of thiazolidinediones modulators, stabilized R-enantiomer of pioglitazone DRX-065, and dual PPAR-a/c agonists, some of which yielded promising results in preclinical/phase I-II clinical studies.
The Median Split: Robust, Refined, and Revived

In this rebuttal, we discuss the comments of Rucker, McShane, and Preacher (2015) and McClelland, Lynch, Irwin, Spiller, and Fitzsimons (2015). Both commentaries raise interesting points, and although both teams clearly put a lot of work into their papers, the bottom line is this: our research sets the record straight that median splits are perfectly acceptable to use when independent variables are uncorrelated. The commentaries do a good job of furthering the discussion to help readers better develop their own preferences, which was the purpose of our paper. In the final analysis, neither of the commentaries pose any threat to our findings of the statistical robustness and valid use of median splits, and accordingly we can reassure researchers (and reviewers and journal editors) that they can be confident that when independent variables are uncorrelated, it is totally acceptable to conduct median split analyses.
The E3 ubiquitin ligase HOS1 is involved in ethylene regulation of leaf expansion in Arabidopsis

Ethylene regulates a variety of physiological processes, such as flowering, senescence, abscission, and fruit ripening. In particular, leaf expansion is also controlled by ethylene in Arabidopsis. Exogenous treatment with ethylene inhibits leaf expansion, and consistently, ethylene insensitive mutants show increased leaf area. Here, we report that the RING finger-containing E3 ubiquitin ligase HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1 (HOS1) regulates leaf expansion in an ethylene signaling pathway. The HOS1-deficient mutant showed reduced leaf area and was insensitive to ethylene perception inhibitor, silver thiosulfate (STS). Accordingly, genes encoding ethylene signaling components were significantly up-regulated in hos1-3. This study demonstrates that the HOS1 protein is involved in ethylene signal transduction for the proper regulation of leaf expansion possibly under environmentally stressful conditions.
Membrane-associated virus replication complexes locate to plant conducting tubes

It is generally accepted that in order to establish a systemic infection in a plant, viruses move from the initially infected cell to the vascular tissues by cell-to-cell movement through plasmodesmata (PD), and load into the vascular conducting tubes (i.e. phloem sieve elements and xylem vessel elements) for long-distance movement. The viral unit in these movements can be a virion or a yet-to-be-defined ribonucleic protein (RNP) complex. Using live-cell imaging, our laboratory has previously demonstrated that membrane-bound replication complexes move cell-to-cell during turnip mosaic virus (TuMV) infection. Our recent study shows that these membrane-bound replication complexes end up in the vascular conducting tubes, which is likely the case for potato virus X (PVX) also. The presence of TuMV-induced membrane complexes in xylem vessels suggests that viral components could also be found in other apoplastic regions of the plant, such as the intercellular space. This possibility may have implications regarding how we approach the study of plant innate immune responses against viruses.
Effects of Bacterial Vaginosis-Associated Bacteria and Sexual Intercourse on Vaginal Colonization With the Probiotic Lactobacillus crispatus CTV-05

Objective: Several fastidious bacteria have been associated with bacterial vaginosis (BV), but their role in lactobacilli recolonization failure is unknown. We studied the effect of 7 BV-associated bacterial species and 2 Lactobacillus species on vaginal colonization with Lactobacillus crispatus CTV-05 (LACTIN-V). Methods: Twenty-four women with BV were given a 5-day course of metronidazole vaginal gel and then randomized 3:1 to receive either LACTIN-V or placebo applied vaginally once daily for 5 initial consecutive days, followed by a weekly application over 2 weeks. Vaginal swabs for L. crispatus CTV-05 culture and 9 bacterium-specific 16S rRNA gene quantitative polymerase chain reaction assays were analyzed on several study visits for the 18 women receiving LACTIN-V. Results: Vaginal colonization with CTV-05 was achieved in 61% of the participants receiving LACTIN-V at either day 10 or day 28 visit and 44% at day 28. Participants not colonized with CTV-05 had generally higher median concentrations of BV-associated bacteria compared to those who colonized. Between enrollment and day 28, the median concentration of Gardnerella vaginalis minimally reduced from 104.5 to 104.3 16S rRNA gene copies per swab in women who colonized with CTV-05 but increased from 105.7 to 107.3 in those who failed to colonize (P = 0.19). Similarly, the median concentration of Atopobium spp. reduced from 102.7 16S rRNA gene copies per swab to below limit of detection in women who colonized with CTV-05, but increased from 102.7 to 106.6 in those who failed to colonize (P = 0.04). The presence of endogenous L. crispatus at enrollment was found to be significantly associated with a reduced odds of colonization with CTV-05 on day 28 (P = 0.003), and vaginal intercourse during the study significantly impaired successful CTV-05 colonization (P = 0.018). Conclusion: Vaginal concentration of certain BV-associated bacteria, vaginal intercourse during treatment, and the presence of endogenous L. crispatus at enrollment predict colonization with probiotic lactobacilli.
iv. Follow-up Record and Outcome

Between 14.4. 60 and 30.9. 60 a follow-up enquiry was carried out, combined with the genetical investigation which has been reported in previous pages. The informants for the genetical enquiry were also the ones who gave information about the patient's recent history. The period covered by follow-up was therefore from one to three years after the time at which hospital investigations had been carried out; and if related to the onset of the schizophrenia-like psychosis was at a mean period of 7.8 years later (range from 2 to 25 years). In addition to this the National Hospital patients have continued to be followed up from that time to the present date, as they and their relatives are asked to attend regularly at a follow-up clinic at the hospital. What is reported here relates to the findings in the special enquiry; but the data that have come in since do not suggest any modification of the conclusions that will be based on the survey of 1960. A synoptic view of these findings is given in Table I.
Inflammation is independent of steatosis in a murine model of steatohepatitis

Obesity and alcohol consumption synergistically promote steatohepatitis, and neutrophil infiltration is believed to be associated with steatosis. However, the underlying mechanisms remain obscure. Peroxisome proliferator–activated receptor gamma (PPARγ) plays a complex role in lipid metabolism and inflammation; therefore, the purpose of this study was to dissect its role in regulating steatosis and neutrophil infiltration in a clinically relevant mouse steatohepatitis model of 3‐month high‐fat diet (HFD) feeding plus a binge of ethanol (HFD‐plus‐binge ethanol). Hepatocyte‐specific Pparg disruption reduced liver steatosis but surprisingly increased hepatic neutrophil infiltration after HFD‐plus‐binge ethanol. Knockout or knockdown of the PPARγ target gene, fat‐specific protein 27, reduced steatosis without affecting neutrophil infiltration in this model. Moreover, hepatocyte‐specific deletion of the Pparg gene, but not the fat‐specific protein 27 gene, markedly up‐regulated hepatic levels of the gene for chemokine (C‐X‐C motif) ligand 1 (Cxcl1, a chemokine for neutrophil infiltration) in HFD‐plus‐binge ethanol‐fed mice. In vitro, deletion of the Pparg gene also highly augmented palmitic acid or tumor necrosis factor alpha induction of Cxcl1 in mouse hepatocytes. In contrast, activation of PPARγ with a PPARγ agonist attenuated Cxcl1 expression in hepatocytes. Palmitic acid also up‐regulated interleukin‐8 (a key chemokine for human neutrophil recruitment) expression in human hepatocytes, which was attenuated and enhanced by cotreatment with a PPARγ agonist and antagonist, respectively. Finally, acute ethanol binge markedly attenuated HFD‐induced hepatic PPARγ activation, which contributed to the up‐regulation of hepatic Cxcl1 expression post–HFD‐plus‐binge ethanol. Conclusion: Hepatic PPARγ plays an opposing role in controlling steatosis and neutrophil infiltration, leading to dissociation between steatosis and inflammation; acute ethanol gavage attenuates hepatic PPARγ activation and subsequently up‐regulates hepatic CXCL1/interleukin‐8 expression, thereby exacerbating hepatic neutrophil infiltration. (Hepatology 2017;66:108–123).
Dating Anxiety in Adolescents and Young Adults With Food Allergies: A Comparison to Healthy Peers

The present study sought to examine dating anxiety and problems in social relationships and health-related quality of life in adolescents and young adults with food allergies compared with their healthy peers. It was hypothesized that individuals with food allergies would experience greater dating anxiety and poorer social functioning and physical and mental health–related quality of life than their healthy peers. Participants with food allergies were age, gender, and ethnicity matched to young adults without a history of allergies or any other chronic illness for analyses. The majority of adolescents and young adults with food allergies reported that their allergies interfere with physical intimacy with their current partner. Results further revealed that adolescents and young adults with food allergies reported greater dating anxiety and fear of negative evaluation than healthy peers. No differences were observed between the groups on physical or mental health–related quality of life or social functioni.
New perspective of the bHLH-MYB complex in jasmonate-regulated plant fertility in arabidopsis

ABSTRACT Jasmonates (JAs) are a class of plant hormones, essential in plant development and defense. JA induces the interaction of the JA receptor Coronatine Insensitive 1 with jasmonate ZIM-domain (JAZ) proteins, and promotes subsequent JAZs degradation, leading to the release of downstream factors and activation of diverse plant development and defense processes. We recently revealed that the IIIe bHLH transcription factors MYC2, MYC3, MYC4 and MYC5 interact with the MYB transcription factors MYB21 and MYB24 to form the bHLH-MYB complex, and JAZs repress the bHLH-MYB complex to regulate JA-mediated stamen development. Here, we further discuss the different properties of the components of the bHLH-MYB complex in expression pattern and stamen regulation.
Treatment of patients waitlisted for liver transplant with all‐oral direct‐acting antivirals is a cost‐effective treatment strategy in the United States

All‐oral direct acting antivirals (DAAs) have been shown to have high safety and efficacy in treating patients with hepatitis C virus (HCV) awaiting liver transplant (LT). However, there is limited empirical evidence comparing the health and economic outcomes associated with treating patients pre‐LT versus post‐LT. The objective of this study was to analyze the cost‐effectiveness of pre‐LT versus post‐LT treatment with an all‐oral DAA regimen among HCV patients with hepatocellular carcinoma (HCC) or decompensated cirrhosis (DCC). We constructed decision‐analytic Markov models of the natural disease progression of HCV in HCC patients and DCC patients waitlisted for LT. The model followed hypothetical cohorts of 1,000 patients with a mean age of 50 over a 30‐year time horizon from a third‐party US payer perspective and estimated their health and cost outcomes based on pre‐LT versus post‐LT treatment with an all‐oral DAA regimen. Transition probabilities and utilities were based on the literature and hepatologist consensus. Sustained virological response rates were sourced from ASTRAL‐4, SOLAR‐1, and SOLAR‐2. Costs were sourced from RedBook, Medicare fee schedules, and published literature. In the HCC analysis, the pre‐LT treatment strategy resulted in 11.48 per‐patient quality‐adjusted life years and $365,948 per patient lifetime costs versus 10.39 and $283,696, respectively, in the post‐LT arm. In the DCC analysis, the pre‐LT treatment strategy resulted in 9.27 per‐patient quality‐adjusted life years and $304,800 per patient lifetime costs versus 8.7 and $283,789, respectively, in the post‐LT arm. As such, the pre‐LT treatment strategy was found to be the most cost‐effective in both populations with an incremental cost‐effectiveness ratio of $74,255 (HCC) and $36,583 (DCC). Sensitivity and scenario analyses showed that results were most sensitive to the utility of patients post‐LT, treatment sustained virological response rates, LT costs, and baseline Model for End‐Stage Liver Disease score (DCC analysis only). Conclusion: The timing of initiation of antiviral treatment for HCV patients with HCC or DCC relative to LT is an important area of clinical and policy research; our results indicate that pre‐LT treatment with a highly effective, all‐oral DAA regimen provides the best health outcomes and is the most cost‐effective strategy for the treatment of HCV patients with HCC or DCC waitlisted for LT. (Hepatology 2017;66:46–56).
Delivery of dsRNA for RNAi in insects: an overview and future directions

Abstract RNA interference (RNAi) refers to the process of exogenous double‐stranded RNA (dsRNA) silencing the complementary endogenous messenger RNA. RNAi has been widely used in entomological research for functional genomics in a variety of insects and its potential for RNAi‐based pest control has been increasingly emphasized mainly because of its high specificity. This review focuses on the approaches of introducing dsRNA into insect cells or insect bodies to induce effective RNAi. The three most common delivery methods, namely, microinjection, ingestion, and soaking, are illustrated in details and their advantages and limitations are summarized for purpose of feasible RNAi research. In this review, we also briefly introduce the two possible dsRNA uptake machineries, other dsRNA delivery methods and the history of RNAi in entomology. Factors that influence the specificity and efficiency of RNAi such as transfection reagents, selection of dsRNA region, length, and stability of dsRNA in RNAi research are discussed for further studies.