Miracle-dz/UniFAR-FTUs huggingface dataset:
A Putative Prophylactic Solution for COVID-19: Development of Novel Multiepitope Vaccine Candidate against SARS-COV-2 by Comprehensive Immunoinformatic and Molecular Modelling Approach

Simple Summary COVID-19, caused by a novel coronavirus, SARS-CoV-2, first emerged in China in December 2019, and then spread around the globe with more than 29 million confirmed infections. Immunoinformatics and molecular modelling techniques are time-efficient methods that are used to accelerate the discovery and design of the candidate peptides for vaccine development against SARS-COV-2. Recently, the use of multiepitope vaccines has proved to be a promising immunization strategy against different viruses and other pathogens. In the current study a comprehensive in silico strategy was used to design stable multiepitope vaccine construct (MVC) from B-cell and T-cell epitopes of essential SARS-CoV-2 proteins which include, spike, main protease, non-structural protein 12 (polymerase), and Nsp13 (helicase) with the help of adjuvants and linkers. Molecular dynamics studies revealed that the MVC displayed favourable molecular interactions with human Toll-like receptors (TLRs), which are known in triggering an innate and adaptive immune response. Furthermore, the MVC was checked for its recombinant production in Escherichia coli using a well-known expression system. The MVC showed a stable three-dimensional structure and could serve as a potential candidate for vaccine production, which warrant further experimental research for validation. Abstract The outbreak of 2019-novel coronavirus (SARS-CoV-2) that causes severe respiratory infection (COVID-19) has spread in China, and the World Health Organization has declared it a pandemic. However, no approved drug or vaccines are available, and treatment is mainly supportive and through a few repurposed drugs. The urgency of the situation requires the development of SARS-CoV-2-based vaccines. Immunoinformatic and molecular modelling are time-efficient methods that are generally used to accelerate the discovery and design of the candidate peptides for vaccine development. In recent years, the use of multiepitope vaccines has proved to be a promising immunization strategy against viruses and pathogens, thus inducing more comprehensive protective immunity. The current study demonstrated a comprehensive in silico strategy to design stable multiepitope vaccine construct (MVC) from B-cell and T-cell epitopes of essential SARS-CoV-2 proteins with the help of adjuvants and linkers. The integrated molecular dynamics simulations analysis revealed the stability of MVC and its interaction with human Toll-like receptors (TLRs), which trigger an innate and adaptive immune response. Later, the in silico cloning in a known pET28a vector system also estimated the possibility of MVC expression in Escherichia coli. Despite that this study lacks validation of this vaccine construct in terms of its efficacy, the current integrated strategy encompasses the initial multiple epitope vaccine design concepts. After validation, this MVC can be present as a better prophylactic solution against COVID-19.
Differences in Biomass Production and Water Use Efficiency among Seven Different Cover Crops in the Wet Winter Seasons of 2016/17 and 2018 in South Carolina

Cover crops can protect soil health and increase climate resilience of crop production systems. Agronomic crop producers in the southern USA often demand information on the best cover crops for their locality and cropping system and on the potential impacts of cover crops on stored soil water. The present research evaluated biomass production and water use efficiency (WUE) of single species and multispecies winter cover crops in South Carolina. Overall, a five-species mixture of Austrian winter pea, rye, crimson clover, hairy vetch, and oats and a single species of rye had the greatest biomass production (4600–6480 kg ha−1) at the end of the season (19 April 2017 in season-1 and 10 May 2018 in season-2). The five-species mixture also had the greatest WUE (2184–2232 g m−3). None of the cover crops depleted soil water (in 60 cm depth) greater than a weed-free fallow maintained through herbicide application and a weedy fallow (no herbicide application). Since both the seasons, in which the present study was conducted, received greater than normal rainfall, further studies should verify the applicability of the results in dry years.
Investigation of High-Sensitivity Piezoresistive Pressure Sensors at Ultra-Low Differential Pressures

The investigation of the pressure sensor chip’s design developed for operation in ultralow differential pressure ranges has been conducted. The optimum geometry of a diaphragm has been defined using available technological resources. The pressure sensor chip with an area of <inline-formula> <tex-math notation="LaTeX">$6.15\times6.15$ </tex-math></inline-formula> mm has an average sensitivity S of 34.5 mV/<inline-formula> <tex-math notation="LaTeX">$\kappa $ </tex-math></inline-formula>Pa/V at nonlinearity 2K<inline-formula> <tex-math notation="LaTeX">$_{NL} =0.81$ </tex-math></inline-formula> %FS and thermal hysteresis up to 0.6 %FS was created. Owing to the chip connection with stop elements, the burst pressure reaches <inline-formula> <tex-math notation="LaTeX">$450~\kappa $ </tex-math></inline-formula>Pa. The developed pressure sensor can be used in medicine, automotive industry and highly specialized scientific developments.
Flies and Disease, Vol. 1: Ecology, Classification and Biotic Associations

Abstract : The volume, providing basic information on the ecology, classification, and biotic associations of synanthropic flies, deals, on a worldwide basis, with more than 350 species of flies in 28 families. It includes original surveys in a thorough treatment of the habits and distribution of many Palearctic and cosmopolitan species. The author discards the earlier view that fly-borne diseases involve only approximately one dozen flies; he shows, instead, how diverse habitats and living patterns produce diverse transmission cycles. The work summarizes the breeding, anthropophilic, and similar relevant habits of about 100 medically important flies in various regions of the world. It includes tabular keys to 200 species of adults and 78 species of larvae, as well as additional keys to important Musca species and to the synanthropic Drosophila. Over 200 original, diagnostic drawings and 15 full-color plates aid the author's explication. Extensive lists of biotic associations, associate more than 340 flies are associated with over 750 other organisms, ranging from viruses through bacteria, fungi, and protozoa to helminths, arthropods, birds, and mammals.
Diyarbakır İlinde Yetişen Badem Ağaçlarından Endofit ve Epifit Bakteri Türlerinin İzolasyonu ve Bitki Gelişimini Teşvik Eden Mekanizmalarının Karakterizasyonu

Bu calismanin amaci, saglikli badem agaclarindan izole edilen bitki gelisimini tesvik eden endofit ve epifit bakteri (PGPB) turlerin tanilanmasi ve bitki gelisimini tesvik eden mekanizmalarinin belirlemektir. MALDI-TOF tanilama analizleri sonucu, 19 izolat Gram-negatif Serratia, Pseudomonas, Ochrobactrum ve Enterobacter, 26 izolat ise Gram-pozitif Bacillus ve Arthrobacter cinsine dahil turler olarak teshis edilmistir. Test edilen izolatlardan, 46 izolat siderofor, 45 izolat amonyak uretiminde pozitif, 35 izolat ise fosforu degisen oranlarda cozebilme yeteneginde olurken, bakterilerin tamami 5.48-127.81 µg/ml konsantrasyon araliginda IAA uretmislerdir. Pseudomonas spp and Enterobacter cloacae izolatlari siderofor, Serratia marcescens izolatlari fosforu cozme, Enterobacter cloacae izolatlari IAA uretme, Bacillus spp ise amonyak uretme etkinliginin yuksek duzeylerde oldugu gorulmustur. Ayni ture bagli endofit bakteri izolatlari epifit bakteri izolatlarina kiyasla bu mekanizmalari daha dusuk duzeyde tesvik ettigi belirlenmistir. Elde edilen sonuclar yuksek duzeyde siderofor, amonyak, IAA uretimi ile fosfor cozme gibi bitki gelisimini tesvik edici ozellikleri sahip PGPB izolatlarinin ekonomik oneme sahip kultur bitkilerin yetistiriciliginde biyolojik gubre olarak kullanilmada potansiyeline sahip oldugunu gostermistir.
Joint Model of Application-Based Ride Hailing Adoption, Intensity of Use, and Intermediate Public Transport Consideration among Workers in Chennai City

The introduction of mobile application-based ride hailing services represents a convergence between technologies, supply of vehicles, and demand in near real time. There is growing interest in quantifying the demand for such services from regulatory, operational, and system evaluation perspectives. Several studies model the decision to adopt ride hailing and the extent of the use of ride hailing, either separately or by bundling them into a single choice dimension, disregarding potential endogeneity between these decisions. Unlike developed countries, the literature is sparser for ride hailing in developing countries, where the demand may differ considerably because of differences in vehicle ownership, and availability and patronage of many transit and intermediate public transport (IPT) modes (the shared modes carrying 40% shares in some cases). This study aims to bridge these gaps in the literature by investigating three interrelated choice dimensions among workers in Chennai city: consideration of IPT modes, the adoption of ride hailing services and the subsequent usage intensity of ride hailing services. The main factors influencing these decisions are identified by estimating a trivariate probit model. The results indicate that sociodemographic and locational characteristics and the availability of IPT modes influence ride hailing adoption, whereas work-related constraints and perception of other modes affect its frequency. Work and non-work characteristics affect both the dimensions of ride hailing. Further, endogeneity is observed between ride hailing and IPT adoption after controlling for these variables, whereas evidence of endogeneity is absent among other dimensions. Mainly, the model separates the effect of the exogenous influences on the usage frequency level from their effect on the adoption of ride hailing services.
The Manufacture and Service Companies Differ Leverage Impact to Financial Performance

The purpose of this research is to examine the leverage from firm. The firm s use leverage to expand their source of fund by using external fund such as debt. By using debt, financial performance of the firm will develop . Beside the leverage, the use of size and inflation are also considered to be the factors that influence the financial performance while the firms are using leverage. As an independent variable, size is reflected by the assets and the leverage or debt by using the debt ratio to the total of assets . Then, the financial performance is reflected by using the return on the measured assets. Inflation as a control variable is included in this research to know the effect towards the financial performance. In this research, firms are divided into two sectors, there are manufacture and service sector. By u sing the manufacture and service sectors in order to know each effect of leverage toward the financial performance, this research focuses to the unique characteristic of these two sectors. Knowing which sector is influenced more by the leverage than the other s, will guide the urgency of this research. This research used the pooled data regression method, 468 data entries of 156 listed firms in Indonesian Stock Exchange . T his research was conducted from 2015 until 2017. The result shows that leverage significantly has a negative effect toward the financial performance and the size positively influences financial performance . Manufacture sector is influenced more in leverage towards the financial performance, and the service sector is influenced more on size towards the financial performance.
Psychosis and psychotic functioning in adolescence

ABSTRACT This paper presents an overview of the main issues that underlie the outbreak of a psychosis in adolescence. The author addresses significant questions that arise in connection with the use of the terms psychosis, psychotic functioning, and adolescent breakdown, examining different theoretical and clinical approaches to psychosis in adolescence. One of the main areas to be explored is the use of the specific diagnosis of psychosis in adolescence when we witness fluctuating mental states, variability, and changeable behaviour. A central point in the development of a psychotic process is the relationship to external reality. This break with reality was characterized by M. and M.E. Laufer as specifically lived out in relation to the reality of the adolescent's changing body. This paper will look at these authors' understanding of psychotic episodes, psychotic functioning, and psychosis, as well as other theoretical perspectives. The paper will address the economic aspects linked to drive increase, the complex interplay of early anxieties, unconscious phantasies and internal object relations, along with the role of identity, the superego and trauma. The paper also discusses different modalities of treatment and stresses the benefit of psychoanalytic treatment for disturbed adolescents.
The Influence of Social Media Usage on the Perceived Business Value and Its Impact on Business Performance of Silver Craft Smes in Celuk Village, Gianyar - Bali

This research aims to determine the role of perceived business value in mediating the influence of social media usage on the performance of Silver Craft SMEs in Celuk Village, Gianyar Regency. The sample in this research is determined using the purposive sampling method and the total sample is 100 respondents. The data analysis techniques used in this research are the confirmatory factor analysis, the Path Analysis technique, and the Sobel test to test the hypothesis regarding the mediation role. The result of this research shows that the usage of social media and perceived business value has a significant and positive influence on business performance. Additionally, perceived business value is also able to significantly mediate the influence of social media usage on business performance. This result affirms that a good usage of social media can increase the perceived business value felt by the silver craft SMEs, which will also have an effect on the increase in business performance.
Comparative Study of Ripening Related Gene Expression and Postharvest Physiological Changes between Astringent and Nonastringent Persimmon Cultivars

‘Mopan’ persimmon (Diospyros kaki Thunb.) is a traditional astringent cultivar of persimmon and ‘Yoho’ persimmon (D. kaki) is a newly introduced Japanese nonastringent type of cultivar in northern China. Studies were conducted to investigate the physiological changes and expression of ripening-related genes in the postharvest process at different periods under the effects of endogenous ethylene in both cultivars. Persimmons were harvested and stored under room temperature for 20 days. An analysis of physiological changes showed significant differences between the two cultivars. Total soluble solids declined in ‘Mopan’ fruit, whereas those in ‘Yoho’ fruit increased during storage. Firmness, color, index of absorbance difference, total and soluble tannin contents, ethylene production, and respiration rates showed the same trend, but these values vary by cultivar. ‘Mopan’ fruit softened rapidly after harvest and attained edible quality in 20 days, with an increased rate of softening accompanied by increased expression of ripening-related genes. In contract, ‘Yoho’ fruit softening occurred slowly and did not soften even after 20 days, with minimal accumulation of the ripening-related genes. The information obtained from this study demonstrates that cell wall-hydrolyzing enzymes, the de-astringent process, and endogenous ethylene have critical roles in postharvest ripening, gene expression, and physiological property changes of ‘Mopan’ and ‘Yoho’ persimmon fruit during storage.
ANALISIS PREDIKSI MAHASISWA MENGUNDURKAN DIRI DARI UNIVERSITAS XYZ DENGAN METODE SUPPORT VECTOR MACHINE

The phenomenon of students resigning is a common thing in private and public universities. The reasons for students resigning are also very diverse, including feeling wrong entering the department, unable to pay tuition, parents who move to work and others. There are even students who resign for no apparent reason. The case of resignation can affect the image of the department and the university concerned. The XYZ University, which is a private university, did not escape the incident. One way to overcome this problem is to predict students who resign from that University. Thus, students who are indicated as having the potential to resign will be given direction and motivation to continue their studies. Prediction is done by the Support Vector Machine (SVM) method which is considered capable of performing predictive analysis well. Implementation of the imbalance sampling method is also applied to unbalanced classes between students who resign and not resign. The imbalance sampling method is the undersampling method, oversampling and a combination of the two methods. The results of the analysis show that the model resulting from the implementation of the SVM method with the kernel Radial Basis Function (RBF) and undersampling is able to predict with 84.47% accuracy, 79.67% sensitivity, 84.80% specificity and AUC 82.23%.
Experimental Validation of High-Performance HIL-Based Real-Time PMU Model for WAMS

This article presents a novel real-time hardware-in-loop-based model for synchronized phasor measurement unit (PMU) which incorporates an adaptive observer to estimate the phasor quantities of the actual hardware-based PMU model. The proposed model is feasible for a wide-area monitoring system (WAMS) in modern power grids. The performance of the proposed model is compared to the conventional algorithms of the performance (P)-class and measurement (M)-class PMU models in terms of total vector error and rate of change of frequency under different scenarios (frequency ramp, unbalance with interharmonics, and out-of-bound offnominal frequency). The main advantages of the proposed model compared to existing models are as follows: (1) combining the advantages of both P and M classes in terms of achieving required standard steady-state performance (IEEE C37.118-2005) while capturing the dynamic system performance, (2) improving the redundancy due to PMU loss, (3) allowing faster implementations and advanced visualization tools, and (4) enhancing WAMS accuracy performance. Despite the advantageous introduced utilizing the proposed model, there is still a tradeoff gap between the investment cost of the installed hardware-based PMUs and system redundancy. Moreover, a laboratory-scale six-bus setup is built and tested to demonstrate the practical validity of the proposed model.
EVALUATING THE EFFECTS OF MATERNAL AND PROGENY DIETARY SUPPLEMENTATION OF SELENIUM YEAST AND VITAMIN E ON THE PERFORMANCE OF BROILER-BREEDER HENS AND PERFORMANCE AND MEAT QUALITY OF PROGENY

OF DISSERTATION EVALUATING THE EFFECTS OF MATERNAL AND PROGENY DIETARY SUPPLEMENTATION OF SELENIUM YEAST AND VITAMIN E ON THE PERFORMANCE OF BROILER-BREEDER HENS AND PERFORMANCE AND MEAT QUALITY OF PROGENY The objectives of these experiments were to evaluate the effects of selenium (Se) and vitamin E (Vit.E) supplementation in maternal and progeny diets on the performance of breeder hens and the performance and meat quality characteristics of progeny. Inclusion of Se, as Se yeast, in the diets of developing broiler breeder pullets resulted in greater Se accumulation of Se (P<0.01) in liver, pancreas, and breast tissues than when Se yeast was not provided. Improving the overall Se status of breeder pullets in the early stages may help maintain adequate tissue Se concentrations during egg production. Maternal supplementation of Se yeast and Vit.E increased the liver and breast Se concentration (P<0.05) of newly hatched chicks compared to the chicks originating from hens not receiving dietary Se. At 7d of age, Se yeast supplementation in either the chick or maternal diet increased breast and liver Se concentrations (P<0.01). At 14d of age, breast and liver Se concentrations remained the highest for chicks supplemented with Se yeast (P<0.01), however there was no effect of maternal Se supplementation. Vitamin E supplementation in either the chick or maternal diets did not affect the liver Vit.E concentrations of chicks at 7 or 14d of age. Supplementing broiler diets with Se yeast and Vit.E improved the meat quality characteristics of raw and marinated breast fillets. The Se content of breast meat from broilers fed Se yeast was higher (P<0.01) than those from broilers that were not fed Se yeast. Antioxidant supplementation improved the drip loss (P<0.05) and oxidative stability (P<0.10) of raw breast fillets after 7d of refrigerated storage. Marination appeared to increase the susceptibility for lipid oxidation of the marinated breast fillets. Dietary supplementation of Se yeast and Vit.E reduced lipid oxidation (P<0.01) of marinated breast fillets after prolonged refrigerated storage, thus improving oxidative stability. Overall, dietary supplementation of Se yeast can increase the accumulation of Se in the tissues of broiler breeder hens and their subsequent progeny. Improvements in the avian antioxidant system may have beneficial effects on the performance of broiler breeder hens, broilers, and the meat quality characteristics of broiler breast fillets.
Señalización y el éxito de las campañas de crowdfunding latinoamericano

Funding opportunities for entrepreneurships in Latin America are few. Commonly being limited to the use of traditional platforms such as public and private banking, or even informal forms of recollecting recourses, none of this particularly fitted to support early stage entrepreneurship. Because of this, new collection mechanisms have emerged, such as reward-based crowdfunding. However, this mechanism presents large percentages of failure and diminished growth rates in comparison to other regions. This empirical research aims to contribute to the understanding of the factors that make a successful campaign from the perspective of signaling theory. Based on the information collected from 21 804 Latin American campaigns, extracted from eight different countries, of the Catarse, Kickstarter and Idea.me platforms. The results indicate that the use of social networks, number of rewards, multimedia material such as images, videos and gifs, as well as efforts of communication with clients, it being during or after the funding phase; have a positive influence in the success of a campaign. Furthermore, all of these are seldom used by the majority of evaluated campaigns, independent of their country of origin or the nature of the campaign itself. The lessened growth of crowdfunding on the region is understood, is at least in part affected due to the inherent quality of the projects, where’s a lot of room for improvement to be made. Palabras clave | keywords Crowdfunding, recompensa, señalización, extracción de datos, comercio en línea, asimetrías, financiamiento, empren-