Miracle-dz/UniFAR-FTUs huggingface dataset:
Green Buildings: Lease Structure, Productivity, and Regional Economic Impacts

In an effort to apply the sustainability movement to the built environment, sustainable construction has gained substantial strength and momentum in global society. A growing body of literature reveals the positive effects of sustainable, or green, buildings in terms of real estate market premiums, energy cost savings, employee productivity, and regional economic growth. In this context, my dissertation examines three research topics pertaining to sustainable buildings, and does so in three separate chapters. The first study discusses the effect of lease structure on the tenant’s willingness to pay for energy-efficient building features, and compares the tenant’s stated willingness to pay with the revealed rental value of those building features. According to the statistical outputs from various regression models, the effect of Triple Net (NNN) lease on the tenant’s willingness to pay for energy-efficient building attributes is positive and statistically significant. Specifically, the NNN tenants were 1.6 times more likely to have greater than or equal to the 2 percent willingness to pay than the Full Service Gross (FSG) tenant group. The second study examines the relationship between sustainable building features and employee productivity. The findings indicate that 58 percent of the tenant respondents recognize that a building’s environment influences their productivity. When it comes to individual features, the analysis reveals that those who are willing to pay more for better
Association of 12 polymorphic variants conferring genetic risk to lung cancer in Indian population: An extensive meta‐analysis

Candidate gene as well as genome‐wide association studies identified several polymorphic variants to be associated with lung cancer worldwide including in India. However, contradictory results have failed to estimate the overall effect of the polymorphic variants on the disease. Textmining was conducted on PubMed following specific search strings to gather all the publications related to genetic association with lung cancer in India. Out of 211 PubMed hits only 30 studies were selected for meta‐analysis following specific inclusion criteria. Heterogeneity between studies was calculated by Cochran's Q‐test (P < 0.05) and heterogeneity index (I2). Publication bias was visualized by funnel plots and Egger's regression test. For each variant, following a fixed‐effect model, summary odds ratio (OR) along with 95% confidence interval (CI) was estimated. The meta‐analysis revealed three polymorphic variants viz. ‘deletion polymorphism (del1) (OR = 1.39, 95% CI = 1.03–1.87, P = 0.027) in GSTT1’, ‘deletion polymorphism (del2) (OR = 1.30, 95% CI = 1.01–1.67, P = 0.038) in GSTM1’ and ‘rs1048943 (OR = 1.98, 95% CI = 1.27–3.10, P = 0.002) in CYP1A1’ to be associated with lung cancer. However, after multiple testing correction, only rs1048943 was found to be significantly associated (P value = 0.0321) with lung cancer. None of the polymorphic variants showed any evidence of heterogeneity between studies or of publication bias. Our meta‐analysis revealed strong association of rs1048943 in CYP1A1, but a suggestive association of deletion polymorphisms in GSTT1 and GSTM1 with lung cancer, which provides a comprehensive insight on the overall effect of the polymorphic variants, reported in various case–control studies on Indian population, on the risk of lung cancer development. Environ. Mol. Mutagen. 58:688–700, 2017. © 2017 Wiley Periodicals, Inc.
State rationale, leveraging strategies and legacies: Rugby World Cup 2011

ABSTRACT This article addresses the following questions: 1) What was the New Zealand government’s rationale behind hosting the Rugby World Cup 2011? 2) What leveraging strategies did the New Zealand government employ? 3) What were the legacies of Rugby World Cup 2011? and 4) To what extent were the legacies evenly distributed throughout the com- munity? Two stages of data collection were conducted. First, a two-phase literature review was conducted. The first phase reviewed literature on state rationale, leveraging strategies and legacies. The second phase reviewed literature examining state rationale, leveraging strategies and legacies of Rugby World Cup 2011. Second, organisational documents such as evaluation reports, strategic plans, ministerial briefing papers and media releases were examined. Economic arguments dominated the government’s rationale, which became clearer over time, and was most clearly articulated after the event. Improved legitimacy was an unstated rationale for the event. To leverage the event, the government created an internal and external network of organisations, event-specific organisations and legislation. The claimed legacies included increased major event capability, a stimulus to the New Zealand economy in 2010 and 2011, and promotion of Brand New Zealand. These benefits were not equally distributed across sectors or geographic communities.
Developmental modification of lipophosphoglycan during the differentiation of Leishmania major promastigotes to an infectious stage.

Protozoan parasites of the genus Leishmania produce the novel surface glycoconjugate, lipophosphoglycan (LPG), which is required for parasite infectivity. In this study we show that LPG structure is modified during the differentiation of L. major promastigotes from a less infectious form in logarithmic growth phase to a highly infectious ‘metacyclic’ form during stationary growth phase. In both stages, the LPGs comprise linear chains of phosphorylated oligosaccharide repeat units which are anchored to the membrane via a glycosyl‐phosphatidylinositol glycolipid anchor. During metacyclogenesis there is (i) an approximate doubling in the average number of repeat units per molecule from 14 to 30, (ii) a pronounced decrease in the relative abundance of repeat units with side chains of beta Gal or Gal beta 1–3Gal beta 1‐, and a corresponding increase in repeat units with either no side chains or with side chains of Arap alpha 1–2 Gal beta 1‐ and (iii) a decrease in the frequency with which the glycolipid anchor is substituted with a single glucose alpha 1‐phosphate residue. While the majority of the LPG phosphoglycan chains are capped with the neutral disaccharide, Man alpha 1–2Man, a significant minority of the chains appeared to terminate in non‐phosphorylated repeat units and may represent incompletely capped species. We suggest that the developmental modification of LPG may be important in modulating the binding of promastigotes to receptors in the sandfly midgut and on human macrophages and in increasing the resistance of metacyclic promastigotes to complement‐mediated lysis.
Estrogen receptor beta gene variant is associated with vascular dementia in elderly women.

OBJECTIVE Alzheimer's disease (AD) and vascular dementia (VaD) are the main causes of dementia. Postmenopausal estrogen deficiency was suggested as a contributor to cognitive decline; however, replacement therapy failed to prove beneficial in its prevention or therapy. Sequence variants in the estrogen receptor alpha gene (ESR1) and beta gene (ESR2) may alter the effects of estrogen. METHODS This is a case-control association study of sporadic AD, VaD, and single-nucleotide polymorphisms in ESR1 (rs2234693 and rs9340799), the TA dinucleotide repeat in the ESR1 promoter, and the rs4986938 single-nucleotide polymorphism in ESR2. Two hundred forty-six women (118 AD, age 83 +/- 7; 60 VaD, age 82 +/- 6; and 68 cognitively intact, age 81 +/- 7) residing in nursing homes were studied. The association of genotypes and AD or VaD was determined by logistic regression analysis adjusted for age and ethnic origin. RESULTS An association of VaD and ESR2 rs4986938 was found. Carriers of each A allele had a 1.7 increased risk compared to carriers of the G allele (odds ratio 1.71, 95% confidence interval 1-2.95). The ApoE epsilon 4 allele was associated with AD (odds ratio 3.35, confidence interval 1.44-7.82), but not with VaD. No association of AD or VaD with ESR1 genotypes or haplotypes was detected. CONCLUSIONS The ESR2 rs4986938 polymorphism is associated with susceptibility for VaD in elderly Jewish women. These results need to be confirmed in replicate studies in other populations.
The Economics, Regulation, and Systemic Risk of Insurance Markets

Despite the importance of insurance in enabling individual and collective social, economic, and financial activities, discussions about the macro-economic role and risks of insurance markets are surprisingly limited. The core motivation for publishing this book is to bring together academics, regulators, and industry experts to provide a multifaceted array of research and perspectives on insurance, its role and functioning, and the potential systemic risk it could create. The first part discusses the macro-economic role of insurance and how insurance is different from banking and general finance. Understanding the differences between the balance sheets of insurers and other financial intermediaries is essential to understand the potential differences in risk nature and differences in optimal regulation. The second part of the book focuses on the risks of the insurance sector and the potential for systemic risk. The various chapters discuss the risks both on the asset and liability sides of insurers' balance sheets. The third part of the book covers the impact of regulation on insurance companies. Existing regulation is often complex and has a large impact on insurance companies' decision-making and functioning. The chapters also illustrate the unintended consequences of various forms of regulation. The book concludes with a summary of a survey that has been conducted in collaboration with McKinsey, where insurance executives have been asked about the risks and regulation in the insurance sector. The survey provides guidance for future research on insurance markets. Contributors to this volume - Viral Acharya, Stern School of Business, New York University Bo Becker, Stockholm School of Economics Denis Duverne, AXA Group Andrew Ellul, Kelley School of Business, Indiana University John Hele, MetLife Inc. Felix Hufeld, German Federal Financial Supervisory Authority Pab Jotikasthira, Kenan-Flagler Business School, University of North Carolina Denis Kessler, SCOR Ralph S. J. Koijen, London Business School Christian Lundblad, Kenan-Flagler Business School, University of North Carolina Amelie de Montchalin, AXA Group Anna Paulson, Federal Reserve Bank of Chicago Thomas Philippon, Stern School of Business, New York University Matthew Richardson, Stern School of Business, New York University Richard Rosen, Federal Reserve Bank of Chicago Christian Thimann, AXA Group Motohiro Yogo, Princeton University
Optimal Contract Design for Joint User Association and Intercell Interference Mitigation in Heterogeneous LTE-A Networks With Asymmetric Information

We study the problem of joint user association and intercell interference (ICI) mitigation in heterogeneous long-term evolution advanced (LTE-A) networks, presuming the absence of the precise global channel state information (CSI). We confront this problem from a contract-theoretic perspective and model the considered network as a labor market where the LTE evolved NodeBs (eNBs) are regarded as the employers offering a contract to the employees (cellular users). We explore a scenario where the wireless channels are ordered into different types according to their link gains and the cost of power consumption. It is assumed that each user knows the type of its channel but is not aware of the types of the channels belonging to other users. Hence, the channel type is regarded as the private information which is known only by the corresponding user. Under the presence of such asymmetric information, the eNBs formulate the optimal contract given by a set of the contract items (the combinations of user association, allocated spectrum, and power) and pass these items to the users, who then select the best contract items according to their channel types. The performance of a proposed contract-based resource allocation mechanism has been evaluated using the OPNET-based simulations. It has been demonstrated that the efficiency of a contract-based mechanism with asymmetric information is close to the optimal method (where the network resources are allocated based on the precise CSI). It has also been shown that the contract-based method outperforms the other relevant resource allocation techniques in terms of the total network service rate and signal-to-noise ratio.
Sensitization trends after renal allograft failure: the role of DQ eplet mismatches in becoming highly sensitized

Sensitization following renal allograft failure (AF) is highly variable. Some patients remain non‐sensitized (NS), while others become highly sensitized (HS). We studied 66 NS patients who experienced AF after initial kidney transplantation. Post‐failure, two main groups of NS panel reactive antibody (PRA) class I and II <10% and HS patients (PRA class I or II ≥80%) were identified. The impact of acute rejection (AR), immunosuppression withdrawal (ISW) at AF, allograft nephrectomy, graft intolerance syndrome (GIS), and both standard serologic and eplet‐based mismatches (MM) in inducing HS status after failure was examined. Late PRA testing post‐failure revealed 18 patients remained NS and 34 patients became HS. African American recipients, ISW at AF, DQB1 eplet MM, and presence of GIS were associated with becoming HS. Presence of total zero eplet MM, zero DQA1/B1 eplet MM, continuation of immunosuppression after failure, and a hyporesponsive immune status characterized by recurrent infections were features of NS patients. DQ eplet MM represents a significant risk for becoming HS after AF. Studies comparing ISW vs. continuation in re‐transplant candidates with high baseline DQ eplet MM burden should be performed. This may provide insights if sensitization post‐AF can be lessened.
[Executive dysfunctions in adults with attention deficit hyperactivity disorder].

INTRODUCTION Several different follow-up studies have shown that attention deficit hyperactivity disorder (ADHD) can persist into adulthood. AIM To review the findings in adults with ADHD related to alterations in the executive functions. DEVELOPMENT Research conducted among children with ADHD has revealed the existence of alterations in different tasks that evaluate the executive functions, such as the planning test, sustained attention tasks, cognitive flexibility, verbal fluency and working memory tasks, as well as several inhibition response tasks. In adults with ADHD, despite the lower number of reports in the literature and the methodological shortcomings that exist in some studies, analogous results have also been described with respect to executive functioning, namely, disorders affecting inhibition response, the capacity for planning, difficulties in cognitive flexibility and verbal fluency, and problems with working memory, which include aspects of spatial working memory, logical or visual memory. CONCLUSIONS The findings we have available at present enable us to confirm the persistence of executive dysfunctions in adult patients with ADHD that are similar to those observed in children with ADHD.
Predictive value of karyotype on outcome of autotransplants for acute myeloid leukemia in second remission

The impact of karyotype on the outcome of patients who undergo autotransplant for acute myeloid leukemia (AML) in second remission (CR2) has not been explored. We evaluated the outcomes of 40 patients who proceeded to autotransplant for AML in CR2 at 2 centers. The median age at autotransplant was 50 years (18-64 years) and the median duration of first remission was 15 months (0.8-51 months). High-dose therapy was melphalan 140-160 mg/m2 plus etoposide 60 mg/kg with or without total body irradiation (22), a busulfan-based regimen (17), and cyclophosphamide alone (1). Six patients (15%) died of treatment-related causes within the first 100 days. Event-free and overall survival at 3 years were both 38% (95% confidence interval 23-53%). At a median follow-up of 76 months (2? -? 170) in surviving patients, 13 (32.5%) are alive and disease free. Graft purging did not significantly influence survival outcome (P=0.94), although platelet engraftment was significantly delayed (P=0.02). The relative risk of an event (relapse or death) for the karyotype risk groups was favorable 1.0; intermediate 4.2 (1.2-14.7); adverse 9.9 (1.5-63.9); unknown 2.3 (0.6-8.8) (P=0.028). We conclude that patients with AML in CR2 who undergo autotransplant can have durable remissions and those with a good risk karyotype are the most likely to obtain long-term disease-free survival.
Interaction of c-Jun Amino-terminal Kinase Interacting Protein-1 with p190 rhoGEF and Its Localization in Differentiated Neurons*

c-Jun amino-terminal kinase (JNK) interacting protein-1 (JIP-1) was originally identified as a cytoplasmic inhibitor of JNK. More recently, JIP-1 was proposed to function as a scaffold protein by complexing specific components of the JNK signaling pathway, namely JNK, mitogen-activated protein kinase kinase 7, and mixed lineage kinase 3. We have identified the human homologue of JIP-1 that contains a phosphotyrosine binding (PTB) domain in addition to a JNK binding domain and an Src homology 3 domain. To identify binding targets for the hJIP-1 PTB domain, a mouse embryo cDNA library was screened using the yeast two-hybrid system. One clone encoded a 191-amino acid region of the neuronal protein rhoGEF, an exchange factor for rhoA. Overexpression of rhoGEF promotes cytoskeletal rearrangement and cell rounding in NIE-115 neuronal cells. The interaction of JIP-1 with rhoGEF was confirmed by coimmunoprecipitation of these proteins from lysates of transiently transfected HEK 293 cells. Using glutathione S-transferase rhoGEF fusion proteins containing deletion or point mutations, we identified a putative PTB binding site within rhoGEF. This binding site does not contain tyrosine, indicating that the JIP PTB domain, like that of Xll α and Numb, binds independently of phosphotyrosine. Several forms of endogenous JIP-1 protein can be detected in neuronal cell lines. Indirect immunofluorescence analysis localized endogenous JIP-1 to the tip of the neurites in differentiated NIE-115 and PC12 cells. The interaction of JIP-1 with rhoGEF and its subcellular localization suggests that JIP-1 may function to specifically localize a signaling complex in neuronal cells.
Discomfort during double-contrast barium enema examination: a placebo-controlled double-blind evaluation of the effect of glucagon and diazepam.

PURPOSE To evaluate the effectiveness of glucagon and diazepam as compared with placebo in decreasing abdominal discomfort in patients during double-contrast barium enema examination. MATERIALS AND METHODS Thirty-six men (n = 9) and women (n = 27) aged 21-62 years with "a lot or terrible discomfort" during double-contrast barium enema examination were randomized into double-blind groups of 12 patients each at the onset of examination. Each group received a placebo, glucagon (1 mg), or diazepam (5 mg) intravenously. Discomfort was scored on a four-point scale by the patients. RESULTS Repeated measures analysis of variance findings indicated that those who received an active drug reported significantly (P = .001) greater relief of discomfort. Discomfort scores improved, on average, 2.2 in the glucagon, 2.0 in the diazepam, and 1.2 in the placebo groups. Colonic spasm did not correlate with abdominal discomfort. CONCLUSION Discomfort during double-contrast barium enema examination can be statistically significantly diminished with a hypotonic agent or a sedative.
Maternal depression and infant cortisol: influences of timing, comorbidity and treatment.

BACKGROUND The current study examines the relationship between maternal depression and infant cortisol concentrations. The potential roles of comorbid maternal anxiety disorders, timing of maternal depression, and maternal treatment with psychotropic medications during pregnancy are addressed. METHODS Women with 6-month-old infants (105 boys and 84 girls) participated in a laboratory paradigm that included infant saliva collection at six points, noise burst and arm restraint stressor tasks, and a diagnostic interview of the mother. RESULTS Lifetime history of maternal depression was associated with increased baseline and mean (average) infant cortisol levels. Comorbidity with anxiety disorder was related to infant cortisol reactivity. Peripartum (prepartum and/or postpartum) maternal depression, rather than a pre-pregnancy history of disorder, was associated with higher infant cortisol reactivity. Prenatal and postnatal exposure to maternal disorder had similar effects, but prenatal maternal psychotropic medication treatment appeared to attenuate infant cortisol increases associated with prenatal maternal disorder exposure. CONCLUSIONS These data suggest that exposure to maternal depression and anxiety during pregnancy and the postpartum period may increase infant salivary cortisol. This maternal depression-infant cortisol association is independent of the effects of delivery complications, and appears to be modulated by prenatal maternal psychotropic treatment.
Type 1 pulmonary epithelial cells: a new compartment involved in the slow phase of particle clearance from alveoli

Abstract Whilst alveolar macrophages normally clear micron-sized particles from the respiratory units, nanoparticles might by-pass this mechanism and interact with alveolar epithelium. This letter discusses the possible role of alveolar epithelial type 1 cells in uptake and retention of nanoparticles within the alveolar septum. Accelerated apoptosis of nanoparticle-laden type 1 cells might trigger pro-inflammatory responses during apoptotic cell removal by macrophages. In the absence of clearance of apoptotic type 1 cells by this route, release of nanoparticles by dead type 1 cells and continued retention within the alveolar septum could lead to a slow process of nanoparticle removel from within the alveolar septum, rather than surface-only clearance. We suggest that this hypothesis warrants further research.
Combined trust model based on evidence theory in iterated prisoner's dilemma game

In the iterated prisoner's dilemma game, agents often play defection based on mutual distrust for the sake of their own benefits. However, most game strategies and mechanisms are limited for strengthening cooperative behaviour in the current literature, especially in noisy environments. In this article, we construct a combined trust model by combining the locally owned information and the recommending information from other agents and develop a combined trust strategy in the iterated prisoner's dilemma game. The proposed game strategy can provide not only a higher payoff for agents, but also a trust mechanism for the system. Furthermore, agents can form their own reputation evaluations upon their opponents and make more rational and precise decisions under our framework. Simulations of application are performed to show the performance of the proposed strategy in noise-free and noisy environments.