Miracle-dz/UniFAR-FTUs huggingface dataset:
Common Mode Noise Reduction of Three-Level Active Neutral Point Clamped Inverters With Uncertain Parasitic Capacitance of Photovoltaic Panels

SiC devices can upgrade the inverter performance to a new level by its potentially more than ten times higher switching speed compared to its Si counterpart. However, the high switching frequency and dv/dt, di/dt worsen the electromagnetic interference. Reduction of the common mode (CM) noise of the non-isolated photovoltaic (PV) inverters is addressed by many researchers through adding filters or balancing the circuit. However, most methods rely on the certainty of the parasitics in the system in advance. It is usually not practical for a PV inverter because the parasitic capacitance of PV panels that are to be installed in plants varies from case to case and further can be seriously affected by the damp environment. This article proposes a practical way to reduce the CM noise of the three-level active neutral point clamped (ANPC) inverters with uncertain parasitic capacitance of PV panels. First, the CM model of ANPC inverters with all parasitic capacitances is established. Next, most existing hardware-based reduction methods of the CM noise are summarized based on a unified mathematical model and further compared with each other. After the comparison, a practical method is proposed to reduce the CM noise of the ANPC inverter with uncertain parasitic capacitances, which just adds little volume and cost to the whole system. Finally, the simulation and experiments are conducted to validate the proposed method.
Resilience and Mental Health: Military mental health training: building resilience

For learning to take place with any kind of efficiency students must be motivated. To be motivated, they must become interested. And they become interested when they are actively working on projects which they can relate to their values and goals in life. Gus Tuberville, President, Penn College Introduction There is no debate that combat places tremendous psychological and physical demands on those involved. And as we learn more about how combat affects the psychological well-being of those involved, a set of central questions emerge. What can we do to prepare service members for the psychological demands of combat? What can we do to sustain the mental health and well-being of those deployed in a combat environment? What can we do to facilitate the return of these service members from the combat environment to home? In short, what do service members need to know about how combat can affect them? In response to these questions, the US Army developed the Battlemind Training System, a mental health resilience building program (US Army Medical Command, 2007). This system established several fundamental principles of mental health training, identified key implementation principles, and defined several important terms. Throughout this chapter, the Battlemind Training System will be used as an exemplar to highlight how a military mental health training program can be created that employs theses principles of mental health training and implementation.
Development of a high-throughput radial migration device

By combining the radial migration assay with injection molded gaskets and a rigid fixture, we have developed a more reliable and sensitive method for measuring radial cell migration. This method is well adapted for use on high throughput automated imaging systems. The use of injection molded gaskets enables low cost replacement of cell-wetted components. Furthermore, the design enables secondary placement of attractants and co-cultures. This device and high-throughput application permit the use of therapeutic screening to evaluate phenotypic responses e.g. cancer cell migration. This approach is orthogonal to other 2D cell migration applications such as scratch wound assays, although here we offer a non-invasive, high-throughput device which is currently not commercially available. Collectively, we have designed a systematic, reliable, high-throughput application to monitor phenotypic responses to chemotherapeutic screens, genetic alterations (e.g. RNAi; CRISPR; others), supplemental regiments, and other approaches offering a reliable methodology to survey unbiased and non-invasive cell migration.
Indicators of Societal Adaptations to Ageing Well

A universal aim for ageing societies is that older people may remain healthy, be functionally independent, and be engaged in society. Various indicators with summary scores have been proposed, which may be used for international comparison or within country monitoring to guide ageing policy development and evaluate effectiveness of such policies. However, it is uncertain whether these indicators may be adapted to countries with different cultures and political systems. Simple indicators such as the Human Development Index may be misleading when compared to more detailed multi domain indices in reflecting the performance of ageing policies in a particular country, such as the Hong Kong Elder Quality of Life Index (EQOLHK). Construction of country specific indicators may be more relevant to shaping ageing policies rather than using indicators just for the sake of international ranking.
The role of proprotein convertase subtilisin/kexin type 9 in atherosclerosis

Dyslipidemia is one of the predominant causes of atherosclerosis and cardiovascular disease (CVD) development. Accordingly, lifestyles approaches and therapeutic targeting of low-density lipoprotein (LDL)-cholesterol remain the main strategies for CVD prevention and treatment. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory serin-protease with important roles in lipoprotein metabolism. In particular, PCSK9 promotes degradation of hepatic LDL-receptors, leading to reduced clearance of LDL particles and increased plasma LDL-cholesterol levels. To date, a large body of evidence from experimental, genetic and clinical studies indicates that PCSK9 is implicated in the development of atherosclerosis. As this research is moving forward, additional roles of PCSK9 beyond cholesterol metabolism and atherosclerosis are being discovered. In the present paper, we will discuss our current knowledge of the role of PCSK9 in atherosclerosis and its associations with cardiometabolic risk factors, and provide a brief overview of the recent achievements in pharmacological inhibition of PCSK9-mediated LDL-receptor degradation toward LDL-cholesterol reduction and prevention of CVD development.
Data Mining of SILC Data: Turkey Case

Official data produced by the National Statistical Institutes (NSIs) have an essential place in the governmental economic and social decision-making process. Addressing official data with data mining methods rather than traditional statistical approaches is crucial to extract new information and hidden patterns. However, the usefulness of data mining methods for official statistics remains unexplored. In the present study, SILC (Survey of Income and Living Conditions) data for the year 2015 conducted by the Turkish Statistical Institute (TurkStat) are examined with data mining methods. Cross-sectional data of 36036 individuals were handled, and the variables affecting the individual income were determined, also the welfare status of the individuals was examined. To determine the socio-economic profiles of individuals, latent class analysis (LCA) and k-modes clustering analysis were used. The socio-economic status of individuals was classified using clustering and random forest (RF) algorithm models. In the LCA model with ten classes, it was obtained which probability of a newly selected individual would belong to which class. The latent class profile definitions of the individuals were obtained according to the variable values obtained from the latent classes with the highest probability. Ten clusters obtained as a result of k-modes were defined according to cluster modes, and cluster profile definitions of individuals were obtained, and also their results were compared with LCA results. In this study, in which categorical variables were considered, it was seen that LCA method provided more consistent results than k-modes method. In the RF model, where individual income is selected as a function of all nine input variables, the importance of the variables was determined. It is observed that education, occupation, and age variables were more important and made the most contribution to the RF model, respectively. In the SILC data, which is an extensive and detailed data, methods such as LCA and RF seem to be appropriate for the application of data mining and obtaining meaningful results from the data. Similar data mining processes can be used to obtain meaningful results for different official data.
Preoperative needed and received information in patients undergoing thoracic surgery in Bangladesh

Thoracic surgical patients often perceive their operation as threatening and experience anxiety, particularly those who are in lack of information. Providing appropriate information enables patients to reduce negative consequences and increase participation in postoperative care. This study aimed to describe the level of preoperative needed and received information among patients undergoing thoracic surgery, and to compare their needed and received information. The descriptive study was conducted in four surgical wards of a national, specialized hospital in Dhaka. Seventy surgical patients were recruited purposively. The Needed Information Questionnaire (NIQ), and the Received Information Questionnaire (RIQ) developed by the researcher were used for data collection. The instruments were validated by three experts and tested for reliability of the NIQ and the RIQ yielding the Cronbach’s alpha coefficients of . 88 and . 87, respectively. Data were analyzed by descriptive statistics and Wilcoxon Signed Ranks test. Overall the average scores of preoperative needed information and received information were at a high level (M = 205, SD = 9.23 and M = 193, SD = 6.73, respectively). The mean scores of preoperative needed information in each dimension
Interaction of Zn(II) and Cu(II) with ε-poly-L-lysine and properties of the complexes

ε-Poly-L-lysine (ε-PL) is a natural food preservative with high safety to humans and a wide antimicrobial spectra. It was found that ε-PL could form precipitates when it contacted to Cu(II) and Zn(II). Thus in this study, two complexes of ZnCl2 and CuCl2 with ε-poly-L-lysine having molecular weights between 2 and 5 kDa were prepared and characterized by elemental analysis (EA), atom absorption spectrometry (AAS), chlorine assay, etc. The results show that the compositions of two complexes can be expressed as [ NH-(CH2)5-CO ] 2n•(ZnCl2)n•2nH2O and [ NH-(CH2)5-CO ] 2n•(CuCl2)n•2nH2O (n=6-18), respectively. The results of FT-IR reveal that the formation of Zn-N and Cu-N coordination bonds. X-RD patterns indicat that the two complexes are new phases different from the raw ε-PL material. On the basis of TG-DTA curves, the complexes have a coordination reaction. From the results of the bacteriostatic test, ε-PL-Zn(II) and ε-PL-Cu(II) have similar antibacterial activity to ligand ε-PL.
Phenotyping in bronchiectasis: Are we moving toward a personalized medicine?

Bronchiectasis (BE) is a heterogeneous disease. Similarly, to other chronic airway diseases, such as asthma and chronic obstructive pulmonary disease, management of BE patients requires a specific and personalized treatment that depends on many clinical, functional, and microbiological variables. Therefore, developing phenotyping methods that can help clinical and therapeutic choices is of paramount importance. Various methodological approaches have been used to personalize patients' management. In this review, we explore the main tools identified so far to classify and phenotype BE patients, including the approaches based on BE etiologies, disease severity, cluster analysis, and endotyping. We also discuss the strengths and limitations of every approach and highlight the similarities and differences between these studies. Finally, we review the therapeutic implications and clinical management connected with each approach.
Free electron laser ablation of soft tissue : the effects of chromophore and pulse characteristics on ablation mechanics.

Background and Objective: Previous studies involving soft tissue ablation with a free electron laser (FEL) have arrived at somewhat conflicting results. Our goal is to investigate the mechanism of soft tissue ablation with the FEL, in order to gain a better understanding of how the numerous laser parameters may impact the clinical outcome of a given laser surgical procedure. Materials and Methods: The ablation depth and threshold radiant exposure were measured in rat skin dermis using the FEL over a broad range of infrared wavelengths (λ = 2.65 − 6.7 μm). The results of the measurements were compared to theoretical models for both the steady-state ablation depth and the ablation threshold. Results: The ablation threshold follows the trend predicted by a basic photothermal model and the ablation depth follows the trend predicted by a steady-state ablation depth model that includes the effect of ablation plume screening. Conclusions: It appears that over a very broad range of midinfrared wavelengths, the results of soft tissue ablation with the FEL are well described by a steady-state ablation model that incorporates the effect of plume screening, and the fundamental mechanism appears to be a water absorption dominated process.
The Role of Methodological Choices in the Effects of Experimental Exposure to Simulated Natural Landscapes on Human Health and Cognitive Performance: A Systematic Review

We review the methods and findings of experiments that have examined the effects of exposure to simulated natural landscapes on human health and cognitive performance. Keyword searches of PubMed, Scopus, and Web of Science resulted in the inclusion of 175 experiments in 148 research articles. that were published/in press by December 31, 2018. We report how often landscape features and human factors are controlled for within these experiments, thereby—for the first time—recording specifically what elements of “nature” and the built/social environment are used when testing the benefits of green space and blue space exposure. We also document all the simulation methods that are used (e.g., duration, number of exposures, senses engaged, and devices used). Next, to determine what methodological decisions influence study findings, we compare positive versus mixed/null or negative findings across 14 potential moderators. Only study quality and outcome measure influence findings; experiments without control groups or randomized treatments reported more positive findings than expected. Experiments studying perceived restoration also reported more positive findings than expected—remarkably, 95% of such experiments reported simulated nature was indeed restorative. We discuss the possibility that these findings may indicate publication bias in favor of overreporting the salutory impacts of natural landscapes. We conclude our review with a synthesis of best practices for future research studies.
Therapeutic Options in Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is one of the more common hereditary cardiac conditions. Several hundreds of mutations in genes coding for sarcomeric or energy metabolism proteins have been found to be associated with the phenotype. Myocardial disarray and fibrosis are the prominent histological findings of the disease. A more common (70%) obstructive (HOCM) has to be distinguished from the less common (30%) non-obstructive phenotype (HNCM). Symptoms include exercise limitation due to dyspnea or angina pectoris, palpitations, or dizziness. Occasionally syncope or sudden cardiac death occurs. Correct diagnosis and risk stratification with respect to prophylactic ICD implantation are essential issues of patient management. Drug therapy in symptomatic patients can be characterized as treatment of heart failure with preserved ejection fraction (HFpEF) in HNCM, while symptoms and the obstructive gradient in HOCM can be addressed with beta-blocking agents or Verapamil. For drug-refractory HOCM, surgical myectomy and percutaneous septal ablation are standard therapies today. The following review summarizes recent developments the management of patients with HCM.
A Mobile Secure Bluetooth-Enabled Cryptographic Provider

The use of digital X509v3 public key certificates, together with different standards for secure digital signatures are commonly adopted to establish authentication proofs between principals, applications and services. One of the robustness characteristics commonly associated with such mechanisms is the need of hardware-sealed cryptographic devices, such as Hardware-Security Modules (or HSMs), smart cards or hardware-enabled tokens or dongles. These devices support internal functions for management and storage of cryptographic keys, allowing the isolated execution of cryptographic operations, with the keys or related sensitive parameters never exposed. The portable devices most widely used are USB-tokens (or security dongles) and internal ships of smart cards (as it is also the case of citizen cards, banking cards or ticketing cards). More recently, a new generation of Bluetooth-enabled smart USB dongles appeared, also suitable to protect cryptographic operations and digital signatures for secure identity and payment applications. The common characteristic of such devices is to offer the required support to be used as secure cryptographic providers. Among the advantages of those portable cryptographic devices is also their portability and ubiquitous use, but, in consequence, they are also frequently forgotten or even lost. USB-enabled devices imply the need of readers, not always and not commonly available for generic smartphones or users working with computing devices. Also, wireless-devices can be specialized or require a development effort to be used as standard cryptographic providers. An alternative to mitigate such problems is the possible adoption of conventional Bluetooth-enabled smartphones, as ubiquitous cryptographic providers to be used, remotely, by client-side applications running in users’ devices, such as desktop or laptop computers. However, the use of smartphones for safe storage and management of private keys and sensitive parameters requires a careful analysis on the adversary model assumptions. The design options to implement a practical and secure smartphone-enabled cryptographic solution as a product, also requires the approach and the better use of the more interesting facilities provided by frameworks, programming environments and mobile operating systems services. In this dissertation we addressed the design, development and experimental evaluation of a secure mobile cryptographic provider, designed as a mobile service provided in
Modular Battery Charger for Light Electric Vehicles

Rapid developments in energy storage and conversion technologies have led to the proliferation of low- and medium-power electric vehicles. Their regular operation typically requires an on-board battery charger that features small dimensions, high efficiency and power quality. This paper analyses an interleaved step-down single-ended primary-inductor converter (SEPIC) operating in the discontinuous conduction mode (DCM) for charging of battery-powered light electric vehicles such as an electric wheelchair. The required characteristics are achieved thanks to favourable arrangement of the inductors in the circuit: the input inductor is used for power factor correction (PFC) without additional elements, while the other inductor is used to provide galvanic isolation and required voltage conversion ratio. A modular interleaved structure of the converter helps to implement low-profile converter design with standard components, distribute the power losses and improve the performance. An optimal number of converter cells was estimated. The converter uses a simple control algorithm for constant current and constant voltage charging modes. To reduce the energy losses, synchronous rectification along with a common regenerative snubber circuit was implemented. The proposed charger concept was verified with a developed 230 VAC to 29.4 VDC experimental prototype that has proved its effectiveness.
Effects of Oprozomib in Combination with Pomalidomide and/or Dexamethasone on Human Multiple Myeloma Tumors Growing in SCID Mice

Introduction: Oprozomib (OPZ) is an irreversible, orally administered proteasome inhibitor (PI). It decreases tumor burden and prevents tumor-related bone loss in preclinical multiple myeloma (MM) studies. In recently published clinical trials, the combination of the PI carfilzomib with the immunomodulatory agent (IMiD) lenalidomide and dexamethasone (Dex) has shown high response rates with durable responses for previously treated and untreated MM patients. Carfilzomib with the IMiD pomalidomide (Pom) and Dex for the treatment of RRMM patients shows promising results (Shah et al, 2013). We evaluated OPZ in combination with Pom and Dex using two of our human MM xenograft models in severe combined immunodeficient (SCID) mice. Methods: Each SCID mouse (n=10/group) was surgically implanted with a 20 - 40 mm3 MM tumor piece into the hind limb. Seven days post-implantation mice were randomized into treatment groups based on human immunoglobulin (Ig) G levels. OPZ stock solution (4 mg/ml) was diluted to 40 mg/kg using 1% carboxymethylcellulose (CMC) and administered twice weekly on two consecutive days via oral gavage.Dex stock solution (10 mg/ml) was diluted to 1 mg/kg using NaCl and administered daily via intraperitoneal injection.Pom stock solution (1 mg/ml) was diluted to 10 mg/kg using 1% CMC and administered daily via oral gavage. Tumor size was measured using calipers and IgG levels by ELISA. Results: Using our human MM model LAGk-1A, treatment with single agent OPZ or Pom produced a minimal reduction in tumor volume when compared with vehicle-treated mice, whereas Dex alone or OPZ + Pom produced more anti-MM effects, and no differences were observed between these two groups. Mice treated with OPZ + Dex or Pom + Dex also showed greater anti-MM activity than OPZ + Pom or Dex alone but the differences were not significant. All three agents together resulted in much smaller tumors when compared to OPZ + Pom on days 35, 42, 49 and 56 (P = 0.0006, P = 0.0001, P = 0.0002 and P Conclusions: These in vivo human MM xenograft studies show that the combination of OPZ + Pom + Dex shows greater anti-MM activity than doublets (Pom + Dex, OPZ + Dex or OPZ + Pom) or single agents, and provides further support for this three drug combination to treat MM. Disclosures Tang:Onyx: Research Funding. Berenson@imbcr.org:Onyx: Consultancy, Honoraria, Research Funding, Speakers Bureau.