Miracle-dz/UniFAR-FTUs huggingface dataset:
Accountable Communities of Health, Health and Social Service Systems Alignment, and Population Health: Eastern Washington State, 2017-2019.

Objectives. To assess health system transformation and alignment in the Better Health Together (BHT) accountable community of health (ACH) region of Eastern Washington.Methods. This trend study leveraged cross-sectional data collected in 2017 and 2019 in Eastern Washington. A total of 165 responses from individuals representing 112 organizations were collected in 2017, and 211 responses from individuals representing 92 organizations were collected in 2019. More than one third (38%; n = 35 organizations) of cases overlapped between the 2 samples. Implementation of the ACH model is the exposure. Outcomes of interest included indicators of system transformation and alignment.Results. Organizations throughout BHT's region became more engaged, less siloed, and better connected from 2017 to 2019. At least some of the increased connectivity observed was directly attributable to the role BHT played in facilitating the creation or maintenance of interorganizational relationships across Eastern Washington.Conclusions. The ACH model is a promising approach to aligning health and social service systems for population health improvement. Evidence shows that ACH organizations can serve as trusted conveners able to facilitate interorganizational relationships across sectors.
Switching the Conformation of 3,2′:6′,3″-tpy Domains in 4′-(4-n-Alkyloxyphenyl)-3,2′:6′,3″-Terpyridines

The preparation and characterization of 4′-(4-n-octyloxyphenyl)-3,2′:6′,3″-terpyridine (8) and 4′-(4-n-nonyloxyphenyl)-3,2′:6′,3″-terpyridine (9) are reported. The single crystal structures of 4′-(4-n-hexyloxyphenyl)-3,2′:6′,3″-terpyridine (6), 4′-(4-n-heptyloxyphenyl)-3,2′:6′,3″-terpyridine (7), and compounds 8 and 9 have been determined. The conformation of the 3,2′:6′,3″-tpy unit is trans,trans in 6 and 7, but switches to cis,trans in 8 and 9. This is associated with significant changes in the packing interactions with a more dominant role for van der Waals interactions between adjacent n-alkyloxy chains and C–Hmethylene. π interactions in 8 and 9. The solid-state structures of 6 and 7 with the n-hexyloxy and n-heptyloxy chains feature interwoven sheets of supramolecular assemblies of molecules, with pairs of n-alkyloxy chains threaded through cavities in an adjacent sheet.
Consideration of Cultural Practices When Characterizing the Vaginal Microbiota Among African and African American Women

This manuscript considers intravaginal practices prevalent among African and African-American women, with the aim of providing a framework for how these practices may affect vaginal health and the vaginal microbiota, and consequently, impact pregnancy outcomes. Intravaginal practices are influenced by traditional socio-cultural beliefs and gender norms, with prominent practices including intravaginal insertion of substances (herbs and traditional medicines), intravaginal cleansing (douching), and anatomical modification of the female organs (labia elongation and female genital mutilation). Common motivations for such practices included hygiene, prevention of infection, enhancement of sexual pleasure, and compliance with societal or cultural norms. The use of soaps and other chemicals for vaginal douching has been reported to reduce diversity of the vaginal microbiota and lower pH, thus increasing the chances of bacterial vaginosis, but the evidence is minimal. The practice of vaginal insertion of natural or other substances is associated with physical abrasions, disruption of the vaginal flora, bacterial vaginosis, and HIV and other infections, but effects on pregnancy outcomes and the vaginal microbiota are unclear. Finally, female genital mutation has been reported to have immediate and prolonged physiological and psychological effects, including frequent infections and chronic inflammation, but similar to most other practices, consequences for preterm birth remain understudied and for the vaginal microbiota, unknown. Overall, findings identify the need for additional research, focusing on how these common practices influence both birth outcomes and the vaginal microbiota, so that nurses, midwives, physicians, and other providers worldwide are better equipped to assess and care for pregnant women.
Quasiconformal-Matrix-Based Multikernels Learning for Sensory Data Classification

Sensory data classiﬁcation is a crucial task in many information processing. The vector data or matrix data are the most common data format, especially matrix data, for example, image data. We propose Gaussian kernel constructing method adaptive to the distribution of the input data for classiﬁcation. In the current matrix based feature extraction, the matrix image is transformed to the vector, and the procedure of transforming will increase the ability of a large saving space and computing. And secondly the diﬀerent geometrical structures under the diﬀerent kernel function will bring the diﬀerent class discrimination of the input data in the feature space. The performance of kernel will be increased under the adaptive choosing the parameters of kernel. We present the matrix Gaussian kernel, Quasiconformal matrix Gaussian kernel, and Quasiconformal matrix multikernels, and we implement the three kinds of kernels on diﬀerent classiﬁers on ORL and Yale image databases. The experimental results show that the proposed kernels perform better than the traditional kernel functions.
Glutamine- and Asparagine-Dependent Protein Synthesis in Maturing Legume Cotyledons Cultured in vitro

Legume cotyledons have been grown in sterile culture and shown to synthesize up to 16 mg protein in 5 d when supplied with either asparagine or glutamine as sole nitrogen sources. Glutamate, nitrate, and ureides also served as nitrogen sources for protein synthesis but to a lesser extent. Methionine sulphoximine and azaserine inhibited asparagine-dependent protein synthesis suggest ing that ammonia is liberated from asparagine which is reassimilated via glutamine synthetase and glutamate synthase.
TECHNICAL REPORT IDI 4th version (2013-08-14)

The IDI instrument The IDI is an instrument that measures and evaluates the impression you make on other persons. The origin of the instrument can be traced back to Zackrison’s (1977) work and PhD dissertation at the University of Michigan, USA. He saw several draw-backs of the instruments used at that time and thus proposed a new instrument. Primarily, Zackrison’s work was focused on the behavior of managerial persons but the present version of the IDI is broader in scope. Actually, Zackrison moved to Sweden in 1981 and worked there as a consultant and continued to revise and develop the instrument for a Swedish context as well as translating the inventory to Swedish. Several statistical analyses were carried out as well as grammatical modifications of the inventory (see Larsson, 2013). The present IDI is the result of this work.
Mental Disorders, Musculoskeletal Disorders and Income-Driven Patterns: Evidence from the Global Burden of Disease Study 2017

Background: The aim of the present study was to use the extensive Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) database from 1990–2017 to evaluate the levels and temporal correlation trends between disability adjusted life years (DALYs) attributed to musculoskeletal (MSK) disorders, all mental disorders collectively and by mental disorder sub-category. Methods: We utilized results of the GBD 2017 to describe the correlation patterns between DALYs due to MSK disorders, mental disorders and other diseases among 195 countries. Mixed model analysis was also applied. Results: A consistent relation was reported between age-adjusted DALYs attributed to MSK and mental disorders (in total) among the 195 countries, in both sexes, for 1990 to 2017 (1990 Rho = 0.487; 2017 Rho = 0.439 p < 0.05). Distinct regional and gender correlation patterns between age-adjusted DALYs due to MSK and mental disorders were reported. No correlation was reported between DALYs due to MSK and all mental disorders collectively, among Low- or Middle-income countries. However, in High-income countries (HICs), the correlation was strong and consistent between 1990 and 2017 (1990 Rho = 0.735; 2017 Rho = 0.727, p < 0.05). Conclusions: The reported correlation patterns call for targeted preventive strategies and intervention policies for mental and MSK disorders internationally. Special attention is needed among HICs.
Effects of Kinect exergames on balance training among community older adults

Abstract Background: Recent years have witnessed wide applications of exergames to balance training among the older adults. However, research concerning balance training with the use of Kinect for Xbox has remained scarce. While previous studies have shown the positive effects of exergames on improving balance and preventing falling among the older adults, there has been a paucity of empirical evidence supporting the superiority of Kinect exercise to conventional exercise over balance training among the older adults. Therefore, this study aimed to compare the feasibility, safety, and effectiveness of Kinect exercise against conventional exercise over balance training among the community older adults. Method: A total of 20 participants were randomly assigned to the Kinect Exercise Group (N = 10) or the Conventional Exercise Group (N = 10) for a 5-week balance training (45 minutes a time, 2 times a week). Assessor blinding was employed to assess the participants’ performance before and after the treatment, including 30-Second Chair Stand Test (30-sec CST), Timed Up and Go (TUG), Functional Reach Test (FRT), and One-Leg Stance Test (OLST) respectively with eyes open and closed. Subjective feeling of the intensity of pain and side effects were recorded throughout the investigation period. Nonparametric statistics was used for data analysis. Results: Within-group comparison between the pre-test and post-test indicated that significant differences existed in all of the 5 tests (30-sec CST, TUG, FRT, OLST with eyes open, and OLST with eyes closed) in the Kinect exercise group. To the Conventional exercise group, however, significant differences were only observed in 30-sec CST, FRT and OLST with eyes open. With regard to between-group comparison, significant differences were only found in FRT. Conclusion: Such results indicated that both treatments were helpful in improving the participants’ balance performance, that Kinect exercise was more effective in terms of overall balance ability, and that Kinect exercise was particularly beneficial to functional reach enhancement in comparison with traditional exercise. Kinect exercise could be a feasible, safe, and effective alternative for dynamic balance training among older adults.
Simultaneous Analysis of Paracetamol and Diclofenac Using MWCNTs-COOH Modified Screen-Printed Carbon Electrode and Pulsed Potential Accumulation

A differential-pulse adsorptive stripping voltammetric (DPAdSV) procedure with the use of pulsed potential accumulation and carboxyl functionalized multiwalled carbon nanotubes modified screen-printed carbon electrode (SPCE/MWCNTs-COOH) was delineated for simultaneous analysis of paracetamol (PA) and diclofenac (DF). The use of carboxyl functionalized MWCNTs and pulsed potential accumulation improves the analytical signals of PA and DF, and minimizes interferences from surfactants. After optimization of analytical conditions for this sensor, the peak currents of the two compounds were found to increase linearly with the increase in their concentration (5.0 × 10−9–5.0 × 10−6 mol L−1 with a detection limit of 1.4 × 10−9 mol L−1 for PA, and 1.0 × 10−10–2.0 × 10−8 mol L−1 with a detection limit of 3.0 × 10−11 mol L−1 for DF). For the first time, the electrochemical sensor allows simultaneous determination of PA and DF at concentrations of 24.3 ± 0.5 nmol L−1 and 3.7 ± 0.7 nmol L−1, respectively, in wastewater samples purified in a sewage treatment plant.
Distribution of fish in tributaries of the lower Taieri/Waipori rivers, South Island, New Zealand

Abstract The distribution of fish within eight small streams feeding into the lower Taieri and Waipori Rivers on the east coast of New Zealand's South Island was examined. A total of eight native and two introduced species were recorded. Eels (Anguilla spp.) and giant kokopu (Galaxias argenteus Gmelin) were the most widely distributed species being located in all streams surveyed. Common bullies (Gobiomorphus cotidianus McDowall) and brown trout (Salmo trutta Linnaeus) were also widely distributed being detected in seven and six of the streams respectively. Three streams of potential conservation significance were identified. These were Picnic Gully Creek which contained a significant population of banded kokopu (Galaxias fasciatus Gray), a Category C threatened species, and Cullens and Alex Creeks which contained significant populations of giant kokopu, a Category B threatened species. The population of giant kokopu in Cullens and Alex Creeks currently represents the largest known population of this species on the east coast of New Zealand (excluding Southland). It has been suggested that brown trout may influence the distribution of native galaxiids. The longitudinal distribution of giant kokopu and brown trout in streams was examined at night using a continuous spotlight sampling approach. Distributions of these two species rarely overlapped at a local scale. Coarse habitat use data indicated that brown trout regularly occupied a variety of habitat types including modified agricultural channels. In contrast, giant kokopu rarely used agricultural channels being predominantly located in pool habitats.
Mice Lacking Connective Tissue Growth Factor in the Forebrain Exhibit Delayed Seizure Response, Reduced C-Fos Expression and Different Microglial Phenotype Following Acute PTZ Injection

Connective tissue growth factor (CTGF) plays important roles in the development and regeneration of the connective tissue, yet its function in the nervous system is still not clear. CTGF is expressed in some distinct regions of the brain, including the dorsal endopiriform nucleus (DEPN) which has been recognized as an epileptogenic zone. We generated a forebrain-specific Ctgf knockout (FbCtgf KO) mouse line in which the expression of Ctgf in the DEPN is eliminated. In this study, we adopted a pentylenetetrazole (PTZ)-induced seizure model and found similar severity and latencies to death between FbCtgf KO and WT mice. Interestingly, there was a delay in the seizure reactions in the mutant mice. We further observed reduced c-fos expression subsequent to PTZ treatment in the KO mice, especially in the hippocampus. While the densities of astrocytes and microglia in the hippocampus were kept constant after acute PTZ treatment, microglial morphology was different between genotypes. Our present study demonstrated that in the FbCtgf KO mice, PTZ failed to increase neuronal activity and microglial response in the hippocampus. Our results suggested that inhibition of Ctgf function may have a therapeutic potential in preventing the pathophysiology of epilepsy.
Inhibition of survivin and its anti-apoptotic splice variant sur-∆Ex3 genes expression followed by apoptosis through carbenoxolone in K562 cells

Background: Leukemia is a malignant and progressive disease. Over-expression of inhibitors of apoptosis proteins (IAPs), such as survivin and its anti-apoptotic variants, including sur-ΔEx3, is the main cause of resistance to apoptotic effects of chemotherapy drugs. In the present study, the effects of CBX on apoptosis and expression level of survivin and sur-ΔEx3 and K562 cells (experimental model of chronic myeloid leukemia) were investigated. Materials and Methods: In this experimental study, human K562 cells were cultured and exposed to CBX. Trypan blue exclusion test was used to evaluate growth inhibitory and viability effects of the drug. Fluorescent microscopy (acridine orange/ ethidium bromide double staining) and DNA electrophoresis were applied to the study of apoptosis. The expression level of survivin and sur-ΔEx3 was studied by semiquantative RTPCR. Results: The results showed that after the 48 h treatment of K562 cells with 150 μM CBX, significant growth inhibitory and apoptotic effects (up to 50%) were induced. In addition, after 2-4 h of treatment with CBX (150 μM), down-regulation of survivin and sur-∆Ex3 were observed. However, the expression level of survivin and sur-ΔEx3 increased to the level of control cells with longer treatment times (6-12 h). Conclusion: Noticing the apoptotic and down-regulatory effects of CBX on survivin and sur-∆Ex3 expression, this drug can be used as a potential candidate for further studies on CML treatment, especially for inhibition of drug resistance in leukemia cells.
Spatial and Temporal Dynamics of Predator-Prey Interactions in Winter Wheat

OF DISSERTATION SPATIAL AND TEMPORAL DYNAMICS OF PREDATOR-PREY INTERACTIONS IN WINTER WHEAT Aphids (Hemiptera: Aphididae) are pests of multiple cropping systems, primarily due to the viruses they vector and direct crop damage that is exacerbated by their rapid population growth. In Kentucky, grain aphids (Rhopalosiphum padi and Sitobion avenae) cause significant yield loss to winter wheat as vectors of Barley Yellow Dwarf virus (BYDV), prompting the routine application of insecticides. Coupled with growing human populations and decreasing arable land, it is increasingly evident that biological control services provided by natural enemies represent a viable long-term management option. Aphids are preyed upon by a diverse array of predators that can be exploited in conservation biological control. I designed a field experiment to monitor dispersal into and out of wheat fields, and how these movements were affected by the surrounding habitat. Analysis revealed there are significant movements of R. padi into the wheat in the fall, and S. avenae in spring, and that these movements are slowed down by forested edges. Natural, field-bordering weed strips were used as a conservation biological technique to enhance predator populations. Results showed that while weed strips did not affect the yield of the crop, aphid abundance, or BYDV incidence, it did significantly increase the abundance of natural enemies. Dominant predators included Coccinellidae, Anthocoridae, Chrysopidae larvae, and Braconidae. Using molecular gut-content analysis, I screened multiple species of predators and found strong trophic linkages between aphids and Orius insidiosus and multiple species of coccinellids, namely Coccinella septempunctata and Coleomegilla maculata. In aphidophagous systems, intraguild predation (IGP) can interfere with the biological control potential so I also screened coccinellids for IGP using newly designed primers. To identify intraguild prey DNA in coccinellids, I designed species-specific primers for C. maculata and C. septempunctata to use in PCR-based molecular gut-content analysis. Results revealed high frequencies of IGP between coccinellids that are significantly higher in weed strip plots. However, I observed no detectable impact on aphid predation during these increased times of IGP, suggesting it does not interfere with biological control of aphids in this system. I discuss the role of weed strips in winter wheat as part of an integrative pest management strategy.
Time Series Analysis and Forecasting with Automated Machine Learning on a National ICD-10 Database

The application of machine learning (ML) for use in generating insights and making predictions on new records continues to expand within the medical community. Despite this progress to date, the application of time series analysis has remained underexplored due to complexity of the underlying techniques. In this study, we have deployed a novel ML, called automated time series (AutoTS) machine learning, to automate data processing and the application of a multitude of models to assess which best forecasts future values. This rapid experimentation allows for and enables the selection of the most accurate model in order to perform time series predictions. By using the nation-wide ICD-10 (International Classification of Diseases, Tenth Revision) dataset of hospitalized patients of Romania, we have generated time series datasets over the period of 2008–2018 and performed highly accurate AutoTS predictions for the ten deadliest diseases. Forecast results for the years 2019 and 2020 were generated on a NUTS 2 (Nomenclature of Territorial Units for Statistics) regional level. This is the first study to our knowledge to perform time series forecasting of multiple diseases at a regional level using automated time series machine learning on a national ICD-10 dataset. The deployment of AutoTS technology can help decision makers in implementing targeted national health policies more efficiently.
Effect of Dietary Olive Cake Supplementation on Performance, Carcass Characteristics, and Meat Quality of Beef Cattle

Simple Summary The consumer’s liking of meat is measured in relation to color, intramuscular fat content, healthy composition of fatty acids, tenderness, juiciness, flavor, and aroma; these qualitative characteristics, influencing the consumer’s choice, guide the market whose objective is to provide safe beef with high food characteristics. The use of agro-industrial co-products, containing appreciable amounts of vegetable oils, could be a feasible strategy to influence the quality of meat. In this study, the effect of the partially destoned olive cake supplementation on the performance, carcass characteristics, and meat quality of beef cattle was evaluated. The experiment was carried out on 45 Limousin bulls divided into three homogenous groups, fed with a diet containing 0%, 7.5%, and 15.0% of the olive cake. Results show that the olive cake supplementation influenced the animal performance, increased the tenderness of meat, the intramuscular fat content and unsaturated fatty acids (oleic acid and essential fatty acids), affecting the meat quality indices and suggesting olive cake as a strategy for the sustainability of the animal food chain, rural economies, and environment, providing healthy animal products. Abstract Dietary partially destoned olive cake supplementation on performance, carcass traits and meat quality of intensively finished bulls was evaluated. Forty-five Limousin bulls, divided into three homogenous groups, received a diet with no supplementation (Control-CTR), 7.5% (Low Olive Cake-LOC), and 15.0% of olive cake supplementation (High Olive Cake-HOC). The trial was realized for 150 days; all bulls were individually weighed at the beginning, middle, and end of the trial, to calculate the individual average daily gain (ADG). At slaughtering, on each carcass, hot weight was recorded and, after 7 days, the pH and temperature were measured. On Longissimus lumborum muscle, color, cooking loss, and shear force of the cooked sample were determined. The chemical composition and the fatty acid content of muscle were determined. Olive cake inclusions (7.5% and 15.0%) increased (p < 0.05) the body weight, ADG, slaughter traits and intramuscular fat content and influenced (p < 0.05) the quality indices. The 15.0% of the inclusion reduced (p < 0.05) the cooking loss and shear force, and increased the unsaturated fatty acid content. The olive cake can be considered as a functional component in beef production and, in substitution to a quote of cereals into the diet of bulls, could be an opportunity to improve agriculture sustainability.