Miracle-dz/UniFAR-FTUs huggingface dataset:
Adaptive Trajectory Tracking for a Planar Two-Wheeled Vehicle with Positive Trail

This paper proposes an adaptive trajectory tracking control for an autonomous planar two-wheeled vehicle subject to nonholonomic constraints. Furthermore, the vehicle model considers a so-called positive trail that provides self-alignment of the steering in many vehicle types, including bicycles. The dynamics of the system is described in a port-Hamiltonian form that is suitable for systematic synthesis of passivity-based controllers. This also enables an explicit description of the system dynamics including the nonholonomic constraints by an ODE. By a generalized canonical transformation, an error system is determined preserving the port-Hamiltonian structure. This reduces the tracking problem to a stabilization problem that is solved by a further transformation. The controller is designed for a structure preserving simplified model and applied to the original model handling the omitted effects due to the simplification as disturbance. Finally, an adaptive controller is applied that, in the port-Hamiltonian framework, guarantees the asymptotic tracking of a given trajectory despite large parameter uncertainties.
Generalized Lower Limb Joint Angular Phase Space Analysis of Subject Specific Normal and Modified Gait

This study presents and applies generalized angular phase space analysis to lower limb joint angles of specific subject during normal and modified gait for discrimination of gait and joint angular movements. Case study of an adult healthy male in-vivo and noninvasive kinematic assessment of skin surface adhesive markers at lower limb was performed at human movement lab during normal gait, stiff knee gait and slow running. Musculoskeletal modeling was performed using AnyGait v.0. 92 morphing Twente Lower Extremity Model (TLEM) to match the size and joint morphology of the stick-figure model. Inverse kinematics was performed obtaining hip, knee and ankle joint flexion-extension angular displacements, velocities and accelerations. Generalized phase space analysis was applied to lower limb joint angular displacements, velocities and accelerations. Directional statistics was applied to generalized phase planes with mean direction, resultant length and circular standard deviation assessment. Rayleigh test was employed for directional concentration and coordination assessment, and Watson’s $\mathrm{U^{2$ goodness of fit test applied to the von Mises distribution. Results point for the importance of subject specific study, generalized joint angular phase space analysis, comparing results with other normalization methods and validation of applied methods with qualitative clinical analysis.
Percutaneous Radiofrequency Ablation of Spinal Osteoid Osteomas Using a Targeted Navigational Bipolar Electrode System

SUMMARY: Safe and effective percutaneous CT-guided radiofrequency ablation of spinal osteoid osteomas can be performed using a targeted navigational bipolar electrode system. Articulating bipolar electrodes with built-in thermocouples along an electrode shaft and variable generator wattage settings allow optimal nidus access, particularly in challenging locations; provide precise real-time monitoring of ablation zone volume and geometry; and minimize the risk of undesired thermal injury.
Crosstalk Reduction in Epimysial EMG Recordings from Transhumeral Amputees with Principal Component Analysis

Electromyographic (EMG) recordings of muscle activity using monopolar electrodes suffer from poor spatial resolution due to the crosstalk from neighbouring muscles. This effect has mainly been studied on surface EMG recordings. Here, we use Principal Component Analysis (PCA) to reduce the crosstalk in recordings from unipolar epimysial electrodes implanted in three transhumeral amputees. We show that the PCA-transformed signals have, on average, a better signal-tonoise ratio than the original unipolar recordings. Preliminary investigations show that this transformation is stable over long periods of time. If the latter is confirmed, our results show that the combination of PCA with unipolar electrodes allows for a higher number of muscles to be targeted in an implant (compared with bipolar electrodes), thus facilitating 1-to-1 proportional control of prosthetic hands.
Interactive Sleep Stage Labelling Tool For Diagnosing Sleep Disorder Using Deep Learning

Traditional manual scoring of the entire sleep for diagnosis of sleep disorders is highly time-consuming and dependent to experts experience. Thus, automatic methods based on electrooculography (EOG) analysis have been increasingly attracted attentions to lower the cost of scoring. Such computeraided diagnosis of sleep disorders are usually based on the 6 scores, wake (W), sleep status (S1–S4) and REM by labelling every 30-second long EOG records. This paper presents an automatic scoring method of sleep stages by using the recent advancements in deep learning. We also suggest an interactive scoring scheme to enable the doctors of practitioners to give feedback by correcting errors and improve the accuracy of scoring as well as diagnosis of sleep disorders.
Mining Effective Patterns of Chinese Medicinal Formulae Using Top-k Weighted Association Rules for the Internet of Medical Things

In China, people have been using traditional Chinese medicine (TCM) to treat diseases for thousands of years. Doctors combine patient symptoms with TCM theory to devise formulae composed of several traditional medicines. With the rapid development of the Internet of Things (IoT), the Internet of Medical Things (IoMT) is gaining popularity in the TCM domain. Consequently, a large number of TCM formulae with different therapeutic effects have been accumulated in IoMT. Therefore, we presented PWFP, which is an efficient methodology for extracting the top-K weighted frequent patterns for IoMT. PWFP guarantees efficient mining performance by estimating the minimum weighted support threshold value. Furthermore, PWFP can be applied in the efficacy-based analysis of these TCM formulae. This study conducted several experiments on both general datasets and TCM formulae for glomerulonephritis stored in IoMT. The rankings of the patterns mined from the prescriptions displayed a good rise in clinical efficacy. Doctors can use these top-k effective patterns as new drug and medicine combination candidates when they conduct drug discovery research and perform clinical medicine selection.
Investigation of the effect of telomerase inhibitor BIBR1532 on breast cancer and breast cancer stem cells

It is emphasized that cancer stem cells (CSCs) forming the subpopulation of tumour cells are responsible for tumour growth, metastasis, and cancer drug resistance. Inadequate response to conventional therapy in breast cancer leads researchers to find new treatment methods and literature surveys that support CSC studies. A selective anticancer agent BIBR1532 inhibits the telomerase enzyme. Many of the chemotherapeutic drugs used in clinical trials have harmful effects, but the advantage of telomerase‐based inhibitors is that they are less toxic to healthy tissues. The phosphoinositide 3‐kinase (PI3K)/serine/threonine kinase (Akt)/mammalian target of rapamycin (mTOR) pathway is common in breast cancer, and the interaction between the mTOR pathway and human telomerase reverse transcriptase (hTERT) is essential for the survival of cancer cells. In our study, we treated MCF‐7, breast cancer stem cell (BCSC) and normal breast epithelial cell MCF10A with the BIBR1532 inhibitor. The IC 50 doses for the 48th hour of BIBR1532 treatment were detected as 34.59 μM in MCF‐7, 29.91 μM in BCSCs, and 29.07 μM in MCF10A. It has been observed that this agent induces apoptosis in the BCSC and MCF‐7 cell lines. According to the results of cell cycle analysis, G 2/M phase accumulation was observed in BCSC and MCF‐7 cell lines. It has also been shown that BIBR1532 suppresses telomerase activity in BCSC and MCF‐7. The effect of BIBR1532 on the mTOR signalling pathway has been investigated for the first time in this study. It is thought that the telomerase inhibitor may bring a new approach to the treatment and it may be useful in the treatment of CSCs.
Gamma‐glutamyltranspeptidase expression by Helicobacter saguini, an enterohepatic Helicobacter species isolated from cotton top tamarins with chronic colitis

Helicobacter saguini is a novel enterohepatic Helicobacter species isolated from captive cotton top tamarins with chronic colitis and colon cancer. Monoassociated H. saguini infection in gnotobiotic IL‐10−/− mice causes typhlocolitis and dysplasia; however, the virulent mechanisms of this species are unknown. Gamma‐glutamyltranspeptidase (GGT) is an enzymatic virulence factor expressed by pathogenic Helicobacter and Campylobacter species that inhibits host cellular proliferation and promotes inflammatory‐mediated gastrointestinal pathology. The aim of this study was to determine if H. saguini expresses an enzymatically active GGT homologue with virulence properties.
Surveillance of Maternal Syphilis in China: Pregnancy Outcomes and Determinants of Congenital Syphilis

Background We sought to describe the epidemiological characteristics of pregnant women with syphilis in Beijing, China, and to investigate the determinants of adverse pregnancy outcomes, including congenital syphilis. Material/Methods We used data from laboratory-confirmed syphilis-infected women who delivered between 2013 and 2015 and were registered in China’s Information Management System for Prevention of Mother-to-Child Transmission of Syphilis. Sociodemographic, clinical, and prevention predictors of adverse pregnancy outcomes (i.e., congenital syphilis, neonatal death, and neonatal asphyxia) were assessed using multivariable regression analyses. Results Among 807 eligible pregnant women with syphilis in Beijing, the maternal syphilis ratios increased from 1.1 (in 2013) to 1.4 (in 2015) per 1000 live births, while adverse pregnancy outcomes decreased, including congenital syphilis (1.3% to 0.4%), neonatal deaths (1.3% to 0%), and neonatal asphyxia (0.9% to 0%). Both prevention and treatment interventions increased, including antenatal testing (93.5% to 93.9%), any treatment (76.6% to 85.2%), adequate treatment (51.1% to 65.1%), and treatment initiated in the first trimester (30.7% to 42.8%). In the logistic regression analysis, higher maternal rapid plasma reagin antibody titers (aOR=1.1 95%CI=1.0–1.1) and third-trimester syphilis diagnosis (aOR=1.7 95%CI=1.1–2.6) were independent risk factors for adverse pregnancy outcomes. Protective factors included being married (aOR=0.4; 95%CI=0.2–0.6) and adequate prenatal treatment (aOR=0.3; 95%CI=0.1–0.7). Conclusions Integrated strategies for maternal syphilis control were associated with improved outcomes but must be strengthened. Future efforts should include education and outreach for antenatal care for at-risk women, syphilis screening at first antenatal care visit, immediate initiation of treatment, and syphilis screening extended to women presenting with miscarriage or stillbirth.
VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters

Overexpression of ATP-binding cassette (ABC) transporters is one of the most important mechanisms responsible for multi-drug resistance (MDR). VS-4718, a tyrosine kinase inhibitor targeting focal adhesion kinase (FAK) with a potential anticancer effect, is currently evaluated in clinical trials. In this study, we investigated whether VS-4718 could reverse MDR mediated by ABC transporters, including ABCB1, ABCG2, and ABCC1. The results showed that VS-4718 significantly reversed ABCB1- and ABCG2-mediated MDR, but not MDR mediated by ABCC1. Treatment of VS-4718 did not alter the protein level and subcellular localization of ABCB1 or ABCG2. Mechanism studies indicated that the reversal effects of VS-4718 were related to attenuation of the efflux activity of ABCB1 and ABCG2 transporters. ATPase analysis indicated that VS-4718 stimulated the ATPase activity of ABCB1 and ABCG2. Docking study showed that VS-4718 interacted with the substrate-binding sites of both ABCB1 and ABCG2, suggesting that VS-4718 may affect the activity of ABCB1 and ABCG2 competitively. This study provided a novel insight for MDR cancer treatment. It indicated that combination of VS-4718 with antineoplastic drugs could attenuate MDR mediated by ABCB1 or ABCG2 in ABCB1- or ABCG2-overexpressing cancer cells.
Demo: Taking Advantage of the Shock Hazard: How to Use an Electric Fence for Data Transfers

The deployment of embedded sensing devices on croplands and pastures is an enabling element for precision agriculture applications. Changing conditions (e.g., different crops being grown), however, may require the occasional reconfiguration of the resulting networks of wireless sensors, e.g., to modify data reporting rates or synchronize internal clocks. In this demo we showcase an opportunistic broadcast channel to forward such configuration messages to embedded systems. The transmitting station is realized by means of an electric fence energizer, a device frequently utilized in agricultural settings. On the receiver side, only little hardware efforts are required to capture the highvoltage pulses and decode transmitted configuration messages.
Diagnostic yield of magnetically assisted capsule endoscopy versus gastroscopy in recurrent and refractory iron deficiency anemia

Abstract Background Small-bowel capsule endoscopy is advocated and repeat upper gastrointestinal (GI) endoscopy should be considered for evaluation of recurrent or refractory iron deficiency anemia (IDA). A new device that allows magnetic steering of the capsule around the stomach (magnetically assisted capsule endoscopy [MACE]), followed by passive small-bowel examination might satisfy both requirements in a single procedure. Methods In this prospective cohort study, MACE and esophagogastroduodenoscopy (EGD) were performed in patients with recurrent or refractory IDA. Comparisons of total (upper GI and small bowel) and upper GI diagnostic yields, gastric mucosal visibility, and patient comfort scores were the primary end points. Results 49 patients were recruited (median age 64 years; 39 % male). Combined upper and small-bowel examination using the new capsule yielded more pathology than EGD alone (113 vs. 52; P < 0.001). In upper GI examination (proximal to the second part of the duodenum, D2), MACE identified more total lesions than EGD (88 vs. 52; P < 0.001). There was also a difference if only IDA-associated lesions (esophagitis, altered/fresh blood, angioectasia, ulcers, and villous atrophy) were included (20 vs. 10; P = 0.04). Pathology distal to D2 was identified in 17 patients (34.7 %). Median scores (0 – 10 for none – extreme) for pain (0 vs. 2), discomfort (0 vs. 3), and distress (0 vs. 4) were lower for MACE than for EGD (P < 0.001). Conclusion Combined examination of the upper GI tract and small bowel using the MACE capsule detected more pathology than EGD alone in patients with recurrent or refractory IDA. MACE also had a higher diagnostic yield than EGD in the upper GI tract and was better tolerated by patients.
Soil pH rather than elevation determines bacterial phylogenetic community assembly on Mt. Norikura

&NA; There is considerable interest in the factors which may explain variation in microbial community assembly processes. In this study, we investigated bacterial community assembly, phylogenetic diversity and the relative role of deterministic and stochastic processes along environmental gradients on Mt. Norikura, Japan. DNA extracted from soil samples collected at a range of elevations was PCR‐amplified targeting the V3 and V4 regions of the bacterial 16S rRNA gene, and sequenced using Illumina MiSeq. We hypothesized that elevation would be a strong predictor of phylogenetic community assembly, with communities being more phylogenetically clustered towards higher elevations, due to more extreme physiological conditions. We also hypothesized a greater role of stochasticity at the highest elevations, due to more frequent soil disturbance. Contrary to our hypotheses, we found that the strength of phylogenetic clustering and the role of stochasticity were strongly related to soil pH, with phylogenetic clustering and deterministic processes being strongest at lower soil pH values. Moreover, there was no trend towards stronger influence of phylogenetic clustering and stochasticity in the upper elevations of Mt. Norikura. These results reveal an overwhelming influence of soil pH on phylogenetic community assembly of soil bacteria, even when a range of other environmental gradients are present. &NA; Graphical Abstract Figure. Soil pH plays a strong role in phylogenetic structuring and mediating the balance between stochastic and deterministic assembly of bacteria.
Influence of the Box Dimensions on the Reliability and Validity of the Sit and Reach in Preschoolers.

Ayán Pérez, C, Martínez de Quel, Ó, Álvarez Pérez, S, and González Baamonde, S. Influence of the box dimensions on the reliability and validity of the sit and reach in preschoolers. J Strength Cond Res XX(X): 000-000, 2018-This study aimed at analyzing the reliability and validity of the sit and reach (SR) test, when it was performed with a standard SR (SSR) or an adapted SR (ASR) box in preschoolers. To accomplish this, both tests were administered 3 times (familiarization, test, and retest) to a group of 148 children (mean age, 4.99 ± 0.94 years; 49.3% girls), with a week interval between each assessment. The obtained results in each test were compared with those obtained in the passive straight leg raise (PSLR) test with the aim of identifying their construct validity. The internal consistency was found to be between good and excellent for the SSR (α: 0.83-0.92) and excellent for the ASR (α: 0.92-0.96). The SSR showed a good and a fair reliability (intraclass correlation coefficient [ICC], 0.71-0.86), whereas the ASR showed an excellent reliability (ICC, 0.90-0.94) except for the 3-year-old children group (ICC, 0.84). Absolute reliability was excellent for the ASR, whereas the SSR yielded higher SEM and minimum detectable change percentage values. Regarding the criterion-related validity, statistically significant fair correlations were observed between both SR tests and the PSLR test. The ASR yielded higher levels of statistical significance as well as greater correlation coefficients than the SSR. This finding indicates that when it comes to assess flexibility through a low cost and easy-to-implement lineal test in preschoolers, it is advisable to use the SR with a box of reduced dimensions.
NoC-Based Support of Heterogeneous Cache-Coherence Models for Accelerators

On-chip shared memory is the primary paradigm for multi-core SoC designs and poses the most critical challenges to their scalability. Choosing the appropriate coherence model for accelerators not only can improve the overall system performance, but can also decrease energy consumption by reducing the accesses to DRAM. We propose an extension of a standard directory-based cache-coherence protocol and present its design as part of a scalable memory hierarchy implemented over a NoC. To evaluate our contribution we designed a many-accelerator SoC architecture that can support three main cache-coherence models for accelerators: non-coherent, last-level-cache-coherent, and fully-coherent. This SoC can run Linux SMP with split last-level cache and multiple DRAM controllers. Our FPGA-based experiments show that the optimal cache-coherence selection varies at run-time, based on the running accelerators and the memory footprint of the applications. Therefore, we support runtime selection of the cache-coherence model for each accelerator, as an alternative to a design-time decision.
Variability of Burnout and Stress Measures in Pediatric Residents: An Exploratory Single-Center Study From the Pediatric Resident Burnout–Resilience Study Consortium

Residency is a high-risk period for physician burnout. We aimed to determine the short-term stability of factors associated with burnout, application of these data to previous conceptual models, and the relationship of these factors over 3 months. Physician wellness questionnaire results were analyzed at 2 time points 3 months apart. Associations among variables within and across time points were analyzed. Logistic regression was used to predict burnout and compassionate care. A total of 74% of residents completed surveys. Over 3 months, burnout (P = .005) and empathy (P = .04) worsened. The most significant cross-sectional relationship was between stress and emotional exhaustion (time 1 r = 0.61, time 2 r = 0.68). Resilience was predictive of increased compassionate care and decreased burnout (P < .05). Mindfulness was predictive of decreased burnout (P < .05). Mitigating stress and fostering mindfulness and resilience longitudinally may be key areas of focus for improved wellness in pediatric residents. Larger studies are needed to better develop targeted wellness interventions.
Comparative gastrointestinal morphology of seven golden mole species (Mammalia: Chrysochloridae) from South Africa

Golden moles are small, fossorial, and primarily insectivorous mammals mostly endemic to South Africa. They belong to an ancient African clade of placental mammals (Afrotheria) that likely radiated from an herbivorous ancestor. Nearly half of the 21 golden mole species are listed as threatened; but remarkably little is known about their basic biology and gastrointestinal tract (GIT) morphology. This study provides a morphometric and histochemical analysis of the GIT of seven chrysochloridae species, including three threatened taxa. Macroscopically, all species examined had simple GITs with simple, wholly glandular stomachs and no cecum. Histologically, the pylorus was dominated by parietal cells. Neutral mucin cells were found on the luminal surface and in the gastric pits, while mixed acid and neutral mucin cells were found in the proximal parts of the gastric glands. The proximal intestine had typical small intestinal histological features such as villi. Typical colonic mucosal features were absent as villi were present throughout the intestinal tract. Goblet cells were abundant and increased toward the distal intestine. These intestinal goblet cells contained mostly mixed mucins. Stomach and intestinal content analysis confirmed the presence of arthropod exoskeleton material and possible small vertebrate remnants, commensurate with a low‐fibre, protein‐rich diet. This may account for their simple GIT morphology, as seen convergently in other unrelated insectivorous mammals. This study provides better representation of variation in GIT morphology among chrysochloridae and within the enigmatic Afrotheria clade. Additionally, it provides a better understanding of the mucin distribution in relation to diet and phylogeny of golden moles.