Miracle-dz/UniFAR-FTUs huggingface dataset:
Portfolio Selection and Performance Evaluation Through Benjamin Graham’s Value Investing

Purpose: The objective of this study is to validate the value investing concerning filtering valued stock in the Indian stock market (Nifty 50) & United States (Dow Jones) during the period 2014 -20. Design /Methodologies/Approach: We have selected the data of the National Stock Exchange and Dow Jones to apply the value investing technique for choosing the stocks and building a significant portfolio. Further, we compare the mean returns of B & H passive strategy. The empirical analysis includes the selected portfolio from Jan 2014 to May 2020. Results & Practical Implication: The mean return of portfolio selected by Value investing outperform as comparative to passive strategy, i.e. Buy & Hold strategy. The successful application of value investing will encourage the practitioners & academicians of financial markets to research & explore further uses & practical impact of the present study.
Efficiency of Single Phage Suspensions and Phage Cocktail in the Inactivation of Escherichia coli and Salmonella Typhimurium: An In Vitro Preliminary Study

Enterobacteriaceae Escherichia coli and Salmonella enterica serovar Typhimurium strains are among the main pathogens responsible for moderate and serious infections at hospital and community environments, in part because they frequently present resistance to antibiotics. As the treatment of Enterobacteriaceae infections is empiric, using the same antibiotics to treat E. coli and Salmonella infections, the same concept can be applied with phages. The use of different phages combined in cocktails, frequently used to circumvent the development of phage-resistant mutants, also allows for the treatment of multiple pathogens, broadening the phages’ action spectrum. As such, the aim of this study was to evaluate the efficiency of a cocktail of two phages (ELY-1, produced on E. coli and phSE-5, produced on S. Typhimurium) to control E. coli and S. Typhimurium. Phages ELY-1 and phSE-5 were effective against E. coli (maximum reductions of 4.5 and 3.8 log CFU/mL, respectively), S. Typhimurium (maximum reductions of 2.2 and 2.6 log CFU/mL, respectively), and the mixture of both bacteria (maximum reductions of 2.2 and 2.0 log CFU/mL, respectively). The cocktail ELY-1/phSE-5 was more effective against S. Typhimurium and the mixture of both bacteria (maximum reduction of 3.2 log CFU/mL for both) than the single phage suspensions and as effective against E. coli as its specific phage ELY-1 (maximum reductions of 4.5 log CFU/mL). The use of both the phage cocktails, as well as the single-phage suspensions, however, did not prevent the occurrence of phage-resistant mutants. Overall, the results indicate that the application of the phages in the form of a cocktail show their potential to be used presumptively, that is, prior to the identification of the pathogens, paving its use to control E. coli or S. Typhimurium.
Variation in sexual brain size dimorphism over the breeding cycle in the three-spined stickleback

ABSTRACT Snapshot analyses have demonstrated dramatic intraspecific variation in the degree of brain sexual size dimorphism (SSD). Although brain SSD is believed to be generated by the sex-specific cognitive demands of reproduction, the relative roles of developmental and population-specific contributions to variation in brain SSD remain little studied. Using a common garden experiment, we tested for sex-specific changes in brain anatomy over the breeding cycle in three-spined stickleback (Gasterosteus aculeatus) sampled from four locations in northern Europe. We found that the male brain increased in size (ca. 24%) significantly more than the female brain towards breeding, and that the resulting brain SSD was similar (ca. 20%) for all populations over the breeding cycle. Our findings support the notion that the stickleback brain is highly plastic and changes over the breeding cycle, especially in males, likely as an adaptive response to the cognitive demands of reproduction (e.g. nest construction and parental care). The results also provide evidence to suggest that breeding-related changes in brain size may be the reason for the widely varying estimates of brain SSD across studies of this species, cautioning against interpreting brain size measurements from a single time point as fixed/static. Summary: Sex-specific changes in brain size over the breeding cycle in the three-spined stickleback may be the reason for varying estimates of sexual brain size dimorphism across studies of this species.
Glutamatergic Innervation onto Striatal Neurons Potentiates GABAergic Synaptic Output

Striatal output pathways are known to play a crucial role in the control of movement. One possible component for shaping the synaptic output of striatal neuron is the glutamatergic input that originates from cortex and thalamus. Although reports focusing on quantifying glutamatergic-induced morphological changes in striatum exist, the role of glutamatergic input in regulating striatal function remains poorly understood. Using primary neurons from newborn mice of either sex in a reduced two-neuron microcircuit culture system, we examined whether glutamatergic input modulates the output of striatal neurons. We found that glutamatergic input enhanced striatal inhibition in vitro. With a glutamatergic partner from either cortex or thalamus, we attributed this potentiation to an increase in the size of quantal IPSC, suggesting a strengthening of the postsynaptic response to GABAergic signaling. Additionally, a differential effect of cortical and thalamic innervation onto striatal GABAergic neurons output was revealed. We observed that cortical, but not thalamic input, enhanced the number of releasable GABAergic synaptic vesicles and morphological synapses. Importantly, these alterations were reverted by blockade of neuronal activity and glutamate receptors, as well as disruption of BDNF-TrkB signaling. Together, our data indicate, for first time, that GABAergic synapse formation in corticostriatal pairs depends on two parallel, but potentially intersecting, signaling pathways that involve glutamate receptor activation in striatal neurons, as well as BDNF signaling. Understanding how cortical and thalamic inputs refine striatal output will pave the way toward dissecting basal ganglia activity in both physiological and pathological conditions. SIGNIFICANCE STATEMENT Striatal GABAergic microcircuits are critical for motor function. However, the mechanisms controlling striatal output, particularly at the level of synaptic strength, are unclear. Using two-neuron culture system, we quantified the synaptic output of individual striatal GABAergic neurons paired with a glutamatergic partner and studied the influence of the excitatory connections that are known to be interregionally formed in vivo. We found that glutamatergic input potentiated striatal inhibitory output, potentially involving an increased feedback and/or feedforward inhibition. Moreover, distinct components of glutamatergic innervation, such as firing activity or release of neurotrophic factors were shown to be required for the glutamatergic-induced phenotype. Investigation, therefore, of two-neuron in vitro microcircuits could be a powerful tool to explore synaptic mechanisms or disease pathophysiology.
Masculinities and Biomedical Governmentality in the Contexts of HIV Prevention and Treatment for Latinx Immigrants

In this article, we discuss notions of masculinities from an understudied group in the United States: Latinx immigrants in regards to medical services regarding HIV and AIDS. We understand this group from the result of the intersection between migration policies and binational discourses, the idea of “vulnerability” and “risk” produced by an acute biomedicalization of bodies and human groups, and gender-particularly masculinity as a discourse that governs sex. Notions were obtained from focalized individual interviews with Latinx immigrants and medical services providers in rural areas of California. Results show that notions on masculinity deploy different forms of sexual behaviors and relationships that diminish men’s responsibility around sexual health and stigmatize femininity and homosexuality. We conclude that reformulating health policies in order to recognize Latino’s vulnerability from cojuntural and intersectional conditions is of most importance.
Lifetime Acts of Violence Assessment (LAVA) predictors of laboratory aggression.

While self-report data warrants interpretive caution in applied settings, these indices serve an important role in exploratory research. The Lifetime Assessment of Violent Acts (LAVA) inventory is a brief, reliable, face-valid questionnaire for estimating the frequency, triggers, and consequences (including injuries to others) of prior acts of aggression. The LAVA also identifies the situational contexts in which prior violence was triggered and provides a basis for risk classifications based on past reactive, intimate partner, alcohol-related, and/or weapon-related violence. Scores on the LAVA indices have been linked to a range of developmental and maladjustment indicators. Associations were found between lab-provoked (Taylor Aggression Paradigm) responding and both dimensional and risk classification scores in this sample (N = 92) of college men. Participants "competed" with a fictional opponent using electric shock as a retaliatory measure for perceived provocation. The total LAVA dimensional score predicted mean shock intensity ( d = .87), baseline responding ( d = 0.90), and past sexual aggression ( d = 1.01). Shock intensities in response to high provocation were predicted ( M d = 0.57) by all but one LAVA index. Participants who reported inflicting one or more injuries on another showed more intense escalations of aggression ( d = 0.46) in response to provocation than normative counterparts. Prior injuries to another ( RR = 2.71), reactive acts of aggression ( RR = 3.73), or intimate-partner violence ( RR = 4.19) elevated the risk of one or more prior acts of self-reported sexual aggression. The limitations and potential value of self-report data were discussed in regard to aggression research.
Approaches to Enhancing Gas Sensing Properties: A Review

A gas nanosensor is an instrument that converts the information of an unknown gas (species, concentration, etc.) into other signals (for example, an electrical signal) according to certain principles, combining detection principles, material science, and processing technology. As an effective application for detecting a large number of dangerous gases, gas nanosensors have attracted extensive interest. However, their development and application are restricted because of issues such as a low response, poor selectivity, and high operation temperature, etc. To tackle these issues, various measures have been studied and will be introduced in this review, mainly including controlling the nanostructure, doping with 2D nanomaterials, decorating with noble metal nanoparticles, and forming the heterojunction. In every section, recent advances and typical research, as well mechanisms, will also be demonstrated.
Stable transgenesis in Astyanax mexicanus using the Tol2 transposase system

Astyanax mexicanus is a well-established and widely used fish model system for evolutionary and developmental biology research. These fish exist as surface forms that inhabit rivers and 30 different populations of cavefish. The establishment of A. mexicanus as an emergent model organism for understanding the evolutionary basis of development and behavior has been accelerated by an increasing availability of genomic approaches to identify genotype-phenotype associations. Despite important progress in the deployment of new technologies, deep mechanistic insights into A. mexicanus evolution and development have been limited by a lack of transgenic lines commonly used in genetic model systems. Here, we expand the toolkit of transgenesis by characterizing two novel stable transgenic lines that were generated using the highly efficient Tol2 system, commonly used to generate transgenic zebrafish. A stable transgenic line consisting of the zebrafish ubiquitin promoter fused to eGFP expressed eGFP ubiquitously throughout development in a surface population of Astyanax. To define specific cell-types, we injected fish with a Cntnap2-mCherry construct that labels lateral line mechanosensory neurons in zebrafish. Strikingly, both constructs appear to label the predicted cell types, suggesting many genetic tools and defined promoter regions in zebrafish are directly transferrable to cavefish. The lines provide proof-of-principle for the application of Tol2 transgenic technology in A. mexicanus. Expansion on these initial transgenic lines will provide a platform to address broadly important problems in the quest to bridge the genotype to phenotype gap.
Desiccation and cracking behaviour of clay loam subjected to different irrigation methods during wetting–drying cycles

Desiccation cracking is a common phenomenon of soil, which potentially affects irrigation and crop growth in farmland. Understanding cracking behaviour aids in developing an effective means of crack prevention or utilization. In the present paper, we report on a phenomenological investigation aimed at exploring the effects of irrigation methods on the cracking behaviour of soil during wetting–drying cycles. Nine identical specimens were prepared and subjected to three irrigation methods (surface irrigation, sprinkling irrigation and drip irrigation) and three wetting–drying cycles. Specimen cracking was monitored by a digital camera and crack patterns were delineated by geometric parameters calculated using image processing techniques. The results showed that the evaporation process of specimens could be roughly divided into three stages according to the variation of evaporation rate. Most cracks were generated during the constant rate stage, although the soil matrix zone was nearly saturated. Surface irrigation increased the cracking water content and cracking degree, in contrast to sprinkling irrigation and drip irrigation. The contribution of crack length propagation and crack width broadening to crack area growth was nearly the same when the soil water content decreased to low values. Stabilized crack networks varied from fractal regimes to uniform distribution regimes with the increasing‐length scale, and the crossover length was independent of irrigation methods and wetting–drying cycles. Under sprinkling irrigation and drip irrigation, cracks formed in the first drying remained as failure zones and most of them reappeared during subsequent drying. However, after surface irrigation most cracks did not propagate in previously cracked zones during subsequent drying, giving rise to shifting crack networks between wetting–drying cycles. Our results provide new insights regarding crack development and evolution in agricultural soil, which will be useful in crack management and irrigation arrangement during crop production.
Activity, not submergence, explains diving heart rates of captive loggerhead sea turtles

ABSTRACT Marine turtles spend their life at sea and can rest on the seafloor for hours. As air-breathers, the breath-hold capacity of marine turtles is a function of oxygen (O2) stores, O2 consumption during dives and hypoxia tolerance. However, some physiological adaptations to diving observed in mammals are absent in marine turtles. This study examined cardiovascular responses in loggerhead sea turtles, which have even fewer adaptations to diving than other marine turtles, but can dive for extended durations. Heart rates (fH) of eight undisturbed loggerhead turtles in shallow tanks were measured using self-contained ECG data loggers under five conditions: spontaneous dives, resting motionless on the tank bottom, resting in shallow water with their head out of water, feeding on squid, and swimming at the surface between dives. There was no significant difference between resting fH while resting on the bottom of the tank, diving or resting in shallow water with their head out of water. fH rose as soon as turtles began to move and was highest between dives when turtles were swimming at the surface. These results suggest cardiovascular responses in captive loggerhead turtles are driven by activity and apneic fH is not reduced by submergence under these conditions. Highlighted Article: Heart rates of undisturbed loggerhead sea turtles were not different whether turtles were submerged or out of water. Rather, heart rates changes were driven by turtles' activity level.
Surgical management of inverted papilloma involving the frontal sinus: a practical algorithm for treatment planning

SUMMARY Inverted papilloma of the frontal sinus is a challenging disease. Given its rarity, only small case series are present in the literature. The objectives of the present study are to review our experience in the surgical management of inverted papillomas involving the frontal sinus and to propose a practical algorithm for selecting the most appropriate approach. Data on patients affected by inverted papilloma involving the frontal sinus and surgically treated between 2002 and 2016 were collected. The type of involvement of frontal sinus and extent of surgery performed (endoscopic endonasal, external or combined approaches) were analysed. A brief review of consistent literature was also carried out. Forty-seven consecutive patients were treated using an exclusive endoscopic endonasal approach (EEA) in 18 cases, while a combined endonasal with external osteoplastic approach was required in 29 cases. Most patients (29/47, 62%) had been treated previously, mainly by an endoscopic approach. A single intraoperative complication occurred (1/47, 2%), i.e. cerebrospinal fluid (CSF) leak, that was successfully repaired intraoperatively without any consequences. Recurrences were observed in only 2/47 cases (4%) after a mean follow-up of 43 months (range, 12-137). The management of inverted papilloma involving the frontal sinus requires great expertise and the surgical technique should be tailored to the site of attachment of the tumour, its extension and the anatomical conformation of each frontal sinus. The encouraging results obtained in this case series support the use of this practical treatment algorithm.
Ultrastructural morphology of goblet cells of the conjunctiva of dogs.

OBJECTIVE To describe the morphology of goblet cells of the eyelid conjunctiva in dogs using transmission and scanning electron microscopy. ANIMAL STUDIED Ten dogs, both male and female of different breeds, with no ocular changes were examined (20 eyes). PROCEDURES Ten samples of conjunctiva were collected and processed for scanning and transmission electron microscopy (SEM and TEM), while another 10 samples were stained with Schiff's periodic stain (SPA) and alcian blue, pH 2.5, and analyzed using light microscopy. RESULTS Scanning electron microscopy revealed several points of mucus extrusion in the free apical portion of the goblet cells as well as a wide distribution of lymphoid follicles and macrophages intermingling with the microvilli of palpebral epithelium cells. TEM revealed normal goblet cells that were predominantly oval with wide cytoplasm of different diameters, and large vesicles with heterogeneous granules and free edges, suggesting the release of mucus content onto the conjunctival surface. Cytoplasmic organelles, such as the Golgi apparatus, endoplasmic reticulum, and a high number of mitochondria were also observed. All the samples were positive for SPA and alcian blue staining. CONCLUSION This is the first study to evaluate the goblet cells of the eyelid conjunctiva in healthy dogs using electron microscopy techniques. These results are useful for comparing the palpebral conjunctiva of dogs without ocular changes to palpebral conjunctiva of dogs and other species with ocular changes.
Group A Streptococcus T Antigens Have a Highly Conserved Structure Concealed under a Heterogeneous Surface That Has Implications for Vaccine Design

Group A Streptococcus (GAS) (Streptococcus pyogenes) is an important human pathogen associated with significant global morbidity and mortality for which there is no safe and efficacious vaccine. The T antigen, a protein that polymerizes to form the backbone of the GAS pilus structure, is a potential vaccine candidate. ABSTRACT Group A Streptococcus (GAS) (Streptococcus pyogenes) is an important human pathogen associated with significant global morbidity and mortality for which there is no safe and efficacious vaccine. The T antigen, a protein that polymerizes to form the backbone of the GAS pilus structure, is a potential vaccine candidate. Previous surveys of the tee gene, which encodes the T antigen, have identified 21 different tee types and subtypes such that any T antigen-based vaccine must be multivalent and carefully designed to provide broad strain coverage. In this study, the crystal structures of three two-domain T antigens (T3.2, T13, and T18.1) were determined and found to have remarkable structural similarity to the previously reported T1 antigen, despite moderate overall sequence similarity. This has enabled reliable modeling of all major two-domain T antigens to reveal that T antigen sequence variation is distributed along the full length of the protein and shields a highly conserved core. Immunoassays performed with sera from immunized animals and commercial T-typing sera identified a significant cross-reactive antibody response between T18.1, T18.2, T3.2, and T13. The existence of shared epitopes between T antigens, combined with the remarkably conserved structure and high level of surface sequence divergence, has important implications for the design of multivalent T antigen-based vaccines.
Insights into the Link between the Organization of DNA Replication and the Mutational Landscape

The generation of a complete and accurate copy of the genetic material during each cell cycle is integral to cell growth and proliferation. However, genetic diversity is essential for adaptation and evolution, and the process of DNA replication is a fundamental source of mutations. Genome alterations do not accumulate randomly, with variations in the types and frequencies of mutations that arise in different genomic regions. Intriguingly, recent studies revealed a striking link between the mutational landscape of a genome and the spatial and temporal organization of DNA replication, referred to as the replication program. In our review, we discuss how this program may contribute to shaping the profile and spectrum of genetic alterations, with implications for genome dynamics and organismal evolution in natural and pathological contexts.