Miracle-dz/UniFAR-FTUs huggingface dataset:
[Study on the liver-protective and choleretic effect of zhizi baipi soup and its disassembled prescription].

OBJECTIVE To investigate the effect of Zhizi Baipi soup and its disassembled prescription on protecting liver and improving choleresis and explore the regularity of Zhizi Baipi soup composition. METHODS The model of mouse liver injury induced by carbon tetraehlofide (CCl4) was used to observe the effects of Zhizi Baipi soup and its disassembled prescription by oral adminstration, the bile volume was determinied by common bile duct drainage. RESULTS Zhizi Baipi soup and each treatment group with gardenia could significantly inhibit the increased serum ATL and AST activities, reduce liver MDA level, and significantly promote the bile flow and bilirubin in bile in normal rats. CONCLUSION Zhizi Baipi soup has effects on protecting liver and increasing bile secretion, its monarch drug, gardenia plays an important role in the decoction, the effect of eliminating dampness and heat are mainly ascribed to the synergic effect of gardenia and phellodendron.
Evolution of secondary software product businesses: Momentum of concurrent enterprising

A growing part of commercial software production is provided by the so-called secondary software industry, involving both software products and services offered by other industries than the actual software industry, i.e. the primary industry. We have been investigating the evolution of businesses in the secondary software industry in two phases, first by developing a framework to analyse the change of host industries from closed and vertical to open and horizontal especially in terms of software products. Secondly, we have studied a set of selected industries in a pivotal era called the momentum of concurrent enterprising in this paper. The key finding is: the value creation is moving towards service offerings - which are product-based, but so that products are designed and built by the other network parties. For the OEM company it is thus essential to estimate how the market opening process will affect the success of its emerging service businesses, including the role of software products in this process.
Complete Genome Sequence of Lymphocystis Disease Virus Isolated from China

ABSTRACT Lymphocystis diseases in fish throughout the world have been extensively described. Here we report the complete genome sequence of lymphocystis disease virus isolated in China (LCDV-C), an LCDV isolated from cultured flounder (Paralichthys olivaceus) with lymphocystis disease in China. The LCDV-C genome is 186,250 bp, with a base composition of 27.25% G+C. Computer-assisted analysis revealed 240 potential open reading frames (ORFs) and 176 nonoverlapping putative viral genes, which encode polypeptides ranging from 40 to 1,193 amino acids. The percent coding density is 67%, and the average length of each ORF is 702 bp. A search of the GenBank database using the 176 individual putative genes revealed 103 homologues to the corresponding ORFs of LCDV-1 and 73 potential genes that were not found in LCDV-1 and other iridoviruses. Among the 73 genes, there are 8 genes that contain conserved domains of cellular genes and 65 novel genes that do not show any significant homology with the sequences in public databases. Although a certain extent of similarity between putative gene products of LCDV-C and corresponding proteins of LCDV-1 was revealed, no colinearity was detected when their ORF arrangements and coding strategies were compared to each other, suggesting that a high degree of genetic rearrangements between them has occurred. And a large number of tandem and overlapping repeated sequences were observed in the LCDV-C genome. The deduced amino acid sequence of the major capsid protein (MCP) presents the highest identity to those of LCDV-1 and other iridoviruses among the LCDV-C gene products. Furthermore, a phylogenetic tree was constructed based on the multiple alignments of nine MCP amino acid sequences. Interestingly, LCDV-C and LCDV-1 were clustered together, but their amino acid identity is much less than that in other clusters. The unexpected levels of divergence between their genomes in size, gene organization, and gene product identity suggest that LCDV-C and LCDV-1 shouldn't belong to a same species and that LCDV-C should be considered a species different from LCDV-1.
Pectoral fin and girdle development in the basal actinopterygians Polyodon spathula and Acipenser transmontanus

The pectoral fins of Acipenseriformes possess endoskeletons with elements homologous to both the fin radials of teleosts and the limb bones of tetrapods. Here we present a study of pectoral fin development in the North American paddlefish, Polyodon spathula, and the white sturgeon, Acipenser transmontanus, which reveals that aspects of both teleost and tetrapod endoskeletal patterning mechanisms are present in Acipenseriformes. Those elements considered homologous to teleost radials, the propterygium and the mesopterygial radials, form via subdivision of an initially chondrogenic plate of mesenchymal cells called the endoskeletal disc. In Acipenseriformes, elements homologous to the sarcopterygian metapterygium develop separately from the endoskeletal disc as an outgrowth of the endoskeletal shoulder girdle that extends into the posterior margin of the finbud. As in tetrapods, the elongating metapterygium and the metapterygial radials form in a proximal to distal order as discrete condensations from initially nonchondrogenic mesenchyme. Patterns of variation seen in the Acipenseriform fin also correlate with putative homology: all variants from the “normal” fin bauplan involved the metapterygium and the metapterygial radials alone. The primary factor distinguishing Polyodon and Acipenser fin development from each other is the composition of the endoskeletal extracellular matrix. Proteoglycans (visualized with Alcian Blue) and Type II collagen (visualized by immunohistochemistry) are secreted in different places within the mesenchymal anlage of the fin elements and girdle and at different developmental times. Acipenseriform pectoral fins differ from the fins of teleosts in the relative contribution of the endoskeleton and dermal rays. The fins of Polyodon and Acipenser possess elaborate endoskeletons overlapped along their distal margins by dermal lepidotrichia. In contrast, teleost fins generally possess relatively small endoskeletal radials that articulate with the dermal fin skeleton terminally, with little or no proximodistal overlap. J. Morphol. 262:608–628, 2004. © 2004 Wiley‐Liss, Inc.
The Biases Influencing an Investor's Behavior in India

This study aims to investigate the impact of behavioral biases on the investor’s financial decision making with special focus on three biases, namely confirmation bias, loss aversion and endowment bias. Investors are always assumed to be rational thinkers as per the traditional economic theories but the volatile market behavior has challenged the efficient market hypothesis. Behavioral finance is a newly developed approach in response to the difficulties faced by the traditional investors. Investment markets are becoming increasingly risky making the investors behave differently upon different market dynamic forces. Recent researches on individual investor’s behavior have shown that people do not act rationally while making decisions, rather several factors influence their decisions whether it is related to stock market or personal financial investments. It is necessary to understand the major cause of irrationality in the markets. Empirical data has been collected through administrating a questionnaire and this data is used to investigate whether investors’ decision making is affected by the three biases. The study with the help of graphical representation of the data and proportionality Chi square analysis (goodness of fit) using SPSS software concludes that the biases have a direct impact on the decisions taken by the investors. This paper attempts to have an insight about the key factors influencing the behavior of the investors with respect to the demographics in relation to the investments and their personal financial decision making process. The findings of this study will be useful for investors to understand the common behaviors, identify their reactions while taking decisions for better returns and take corrective measures to not fall into the trap of the behavioral bias. It is also helpful for the financial planners to device suitable asset allocation strategies for their clients.
Turnip Mosaic Virus RNA Replication Complex Vesicles Are Mobile, Align with Microfilaments, and Are Each Derived from a Single Viral Genome

ABSTRACT Nicotiana benthamiana plants were agroinoculated with an infectious cDNA clone of Turnip mosaic virus (TuMV) that was engineered to express a fluorescent protein (green fluorescent protein [GFP] or mCherry) fused to the viral 6K2 protein known to induce vesicle formation. Cytoplasmic fluorescent discrete protein structures were observed in infected cells, corresponding to the vesicles containing the viral RNA replication complex. The vesicles were motile and aligned with microfilaments. Intracellular movement of the vesicles was inhibited when cells were infiltrated with latrunculin B, an inhibitor of microfilament polymerization. It was also observed that viral accumulation in the presence of this drug was reduced. These data indicate that microfilaments are used for vesicle movement and are necessary for virus production. Biogenesis of the vesicles was further investigated by infecting cells with two recombinant TuMV strains: one expressed 6K2GFP and the other expressed 6K2mCherry. Green- and red-only vesicles were observed within the same cell, suggesting that each vesicle originated from a single viral genome. There were also vesicles that exhibited sectors of green, red, or yellow fluorescence, an indication that fusion among individual vesicles is possible. Protoplasts derived from TuMV-infected N. benthamiana leaves were isolated. Using immunofluorescence staining and confocal microscopy, viral RNA synthesis sites were visualized as punctate structures distributed throughout the cytoplasm. The viral proteins VPg-Pro, RNA-dependent RNA polymerase, and cytoplasmic inclusion protein (helicase) and host translation factors were found to be associated with these structures. A single-genome origin and presence of protein synthetic machinery components suggest that translation of viral RNA is taking place within the vesicle.
A cell adhesion molecule mimetic, FGL peptide, induces alterations in synapse and dendritic spine structure in the dentate gyrus of aged rats: a three‐dimensional ultrastructural study

The FGL peptide is a neural cell adhesion molecule (NCAM) mimetic comprising a 15‐amino‐acid‐long sequence of the FG loop region of the second fibronectin type III module of NCAM. It corresponds to the binding site of NCAM for the fibroblast growth factor receptor 1. FGL improves cognitive function through enhancement of synaptic function. We examined the effect of FGL on synaptic and dendritic structure in the brains of aged (22‐month‐old) rats that were injected subcutaneously (8 mg/kg) at 2‐day intervals until 19 days after the start of the experiment. Animals were perfused with fixative, brains removed and coronal sections cut at 50 µm. The hippocampal volume was measured, tissue embedded and ultrathin sections viewed in a JEOL 1010 electron microscope. Analyses were made of synaptic and dendritic parameters following three‐dimensional reconstruction via images from a series of ∼100 serial ultrathin sections. FGL affected neither hippocampal volume nor spine or synaptic density in the middle molecular layer of the dentate gyrus. However, it increased the ratio of mushroom to thin spines, number of multivesicular bodies and also increased the frequency of appearance of coated pits. Three‐dimensional analysis showed a significant decrease in both post‐synaptic density and apposition zone curvature of mushroom spines following FGL treatment, whereas for thin spines the convexity of the apposition zone increased. These data indicate that FGL induces large changes in the fine structure of synapses and dendritic spines in hippocampus of aged rats, complementing data showing its effect on cognitive processes.
Pain Detection and Amelioration in Animals on the Farm: Issues and Options

Pain in nonhuman animals is a difficult concept to identify and measure. This article briefly describes the consequences of pain in animals on the farm and explains the reasons for the minimal use of analgesics in farmed animals. Pain can have implications for both animal welfare and economics. The reasons for a low use of analgesics in farmed animals include the lack of recognition of animal pain owing to the apparent lack of anthropomorphically identifiable behavioral changes, concern over human food safety, and lack of research efforts to develop safe analgesics for farm use. Treatment cost relative to the benefits expected is another hindering factor. Interventions to minimize pain must begin with developing objective and practical measures for pain identification and measurement at the farm level. A suggested use of a combination of different behavioral and physiological indicators would help to identify pain in animals. To facilitate continued usage of the methodologies on the farm it also is necessary to evaluate the economic implication of the pain alleviation intervention.
Effectiveness of hip protectors for preventing hip fractures in elderly people: systematic review

Abstract Objectives To present the updated results of systematic review of the current evidence for the effectiveness of hip protectors from reports of completed randomised trials, and to explore the evolution of that evidence. Design Systematic review with meta-analysis. Data sources Cochrane Bone, Joint, and Muscle Trauma Group trials register (January 2005), Cochrane central register of controlled trials (Cochrane Library Issue 1, 2005), Medline (1966 to January 2005), Embase (1988 to January 2005), and CINAHL (1982 to December 2004). Other databases and reference lists of relevant articles were searched and some trialists were contacted. Review methods Randomised or quasirandomised controlled trials reporting the incidence of hip fractures, pelvic fractures, and other fractures in elderly people offered hip protectors compared with a control group that was not. Results Outcomes for fracture were available from 14 randomised and quasirandomised trials. Pooling of data from 11 trials carried out in nursing or residential care settings, including six cluster randomised studies, showed evidence of a marginally statistically significant reduction in incidence of hip fracture (relative risk 0.77, 95% confidence interval 0.62 to 0.97). Pooling of data from three individually randomised trials of 5135 community dwelling participants showed no reduction in hip fracture incidence with provision of hip protectors (1.16, 0.85 to 1.59). No evidence was found of any significant effect of hip protectors on incidence of pelvic or other fractures. No important adverse effects of hip protectors were reported, but compliance, particularly in the long term, was poor. Conclusions On the basis of early reports of randomised trials, hip protectors were advocated. Accumulating evidence indicates that hip protectors are an ineffective intervention for those living at home and that their effectiveness in an institutional setting is uncertain.
Black Scholes Option Pricing Model – Brownian Motion Approach

Brownian motion has become one of the fundamental building blocks of modern quantitative finance. The mathematical theory of Brownian motion has been applied in contexts ranging far beyond the movement of particles in fluids. Until recently, stock market researchers have confronted the same problem. While they can chart the path of the market on a minute by minute basis it is very hard for them to observe who buys, who sells and how demand and supply affects price fluctuations. There exist many researchers about how the behavior of different investors makes the option price movement in a stock market. The purpose of this paper is to construct the black Scholes option pricing model in the stock markets by using of Brownian motion approach. The main ambition of this study is fourfold: 1) First we begin our approach to construction of Brownian motion from the simple symmetric random walk. 2) Next we introduce the Black – Scholes option pricing model with stock price movement by using of Geometric Brownian motion. 3) Then we extent this Brownian motion approach in the stock market and 4) Finally we construct the model for the generalization based on the deformation of the standard Brownian motion and Black Scholes pricing formula. And this paper will end with conclusion.
Population Biology of Antigen Presentation by MHC Class I Molecules

In principle, the function of major histocompatibility complex (MHC) molecules is simple: to bind a peptide and engage a T cell. In practice, placing this function within the context of the immune response begs questions of population biology: How does the immune response emerge from the interactions among populations of peptides, T cells, and MHC molecules? Within a population of vertebrates, how does MHC polymorphism stamp individuality on the response? Does polymorphism confer differential advantages in responding to parasites? How are the pressures on the MHC reflected in turnover of alleles? The role of mutation, recombination, selection, and drift in the generation and maintenance of MHC class I polymorphism are considered.
Space-Vector Modulated Multilevel Matrix Converter

A matrix converter is an ac-ac power converter topology that has received extensive research attention as an alternative to traditional ac-dc-ac converter. A matrix converter is able to convert energy from an ac source to an ac load without the need of a bulky and limited-lifetime energy-storage elements. The indirect three-level sparse matrix converter (I3SMC) is a new topology from this family that can synthesize three-level voltage in order to improve the output performance in terms of reduced harmonic content. This paper discusses the operating principles and a space-vector-modulation scheme for this topology. Simulation and experimental results are shown to prove the ability of this topology to generate multilevel output voltages as well as to maintain a set of sinusoidal balanced input currents. The performance of the converter is compared with the conventional matrix converter and an alternative multilevel matrix-converter topology in order to demonstrate the advantages and disadvantages of the I3SMC.
Machine learning algorithms for real time arrhythmias detection in portable cardiac devices: microcontroller implementation and comparative analysis

This paper presents the development of two machine learning algorithms on a 32-bit ARM® Cortex® M4 microcontroller core from Freescale Semiconductors. A neural network (ANN) and a support vector machine (SVM) were implemented for real time detection of ventricular tachycardia (VT) and ventricular fibrillation (VF), and they were compared in terms of accuracy. In the feature extraction step a Fast Wavelet Transform (FWT) was used; which was analyzed using the time-frequency characteristics of energy in each sub-band frequency. For the training and validation algorithms, signals from MIT-BIH database with normal sinus rhythm, VF and VT in a time window of 2 seconds were used. Validation results achieve test accuracy of 99.46% by ANN and SVM in VT/VF detection.
Cancer risk in mutation carriers of DNA‐mismatch‐repair genes

Excessive incidence of various cancers is a challenging feature of the hereditary‐non‐polyposis‐colorectal‐cancer (HNPCC) syndrome. This study estimated the cancer incidences in HNPCC compared with the general population. Individuals in a cohort of 1763 members of 50 genetically diagnosed families were categorized according to their genetic status as mutation carriers, non‐carriers, or individuals at 50 or 25% risk of being a carrier. Incidences of cancers in these groups were compared with those in the Finnish population overall. In 360 mutation carriers, standardized incidence ratios (SIR) were significantly increased for colorectal [68; 95% confidence intervals (CI), 56 to 81], endometrial (62; 95% CI, 44 to 86), ovarian (13; 95% CI, 5.3 to 25), gastric (6.9; 95% CI, 3.6 to 12), biliary tract (9.1; 95% CI, 1.1 to 33), uro‐epithelial (7.6; 95% CI, 2.5 to 18) and kidney (4.7; 95% CI, 1 to 14) cancers and for central‐nervous‐system tumours (4.5; 95% CI, 1.2 to 12). The SIR increased with increasing likelihood of being a mutation carrier. The cumulative cancer incidences were 82, 60, 13 and 12% for colorectal, endometrial, gastric and ovarian cancers respectively. For other tumours associated with increased risk, corresponding incidences were below 4%. Interestingly, the incidence of endometrial cancer (60%) exceeded that for colorectal cancer in women (54%). The tumour spectrum associated with germline mutations of DNA‐mismatch‐repair genes involves 8 or more organ sites, suggesting a need to develop methods to screen for extra‐colonic cancer also. Int. J. Cancer 81:214–218, 1999. © 1999 Wiley‐Liss, Inc.
Comparison of wind turbine/generator configurations for future offshore wind farms

This paper presents the use of induction generator turbine machines with a voltage/frequency (V/Hz) control method to maximise available power from the wind. An offshore wind farm system is proposed and system performance is verified with both step and variable wind. The study will explore the concept of lower than rated frequency performance for the V/Hz design and compare this to conventional wind turbines with real Irish offshore wind data. The paper also discusses the potential for low frequency power loss reduction for both cables and transformers in the wind farm.
mcrA-Targeted Real-Time Quantitative PCR Method To Examine Methanogen Communities

ABSTRACT Methanogens are of great importance in carbon cycling and alternative energy production, but quantitation with culture-based methods is time-consuming and biased against methanogen groups that are difficult to cultivate in a laboratory. For these reasons, methanogens are typically studied through culture-independent molecular techniques. We developed a SYBR green I quantitative PCR (qPCR) assay to quantify total numbers of methyl coenzyme M reductase α-subunit (mcrA) genes. TaqMan probes were also designed to target nine different phylogenetic groups of methanogens in qPCR assays. Total mcrA and mcrA levels of different methanogen phylogenetic groups were determined from six samples: four samples from anaerobic digesters used to treat either primarily cow or pig manure and two aliquots from an acidic peat sample stored at 4°C or 20°C. Only members of the Methanosaetaceae, Methanosarcina, Methanobacteriaceae, and Methanocorpusculaceae and Fen cluster were detected in the environmental samples. The three samples obtained from cow manure digesters were dominated by members of the genus Methanosarcina, whereas the sample from the pig manure digester contained detectable levels of only members of the Methanobacteriaceae. The acidic peat samples were dominated by both Methanosarcina spp. and members of the Fen cluster. In two of the manure digester samples only one methanogen group was detected, but in both of the acidic peat samples and two of the manure digester samples, multiple methanogen groups were detected. The TaqMan qPCR assays were successfully able to determine the environmental abundance of different phylogenetic groups of methanogens, including several groups with few or no cultivated members.