Miracle-dz/UniFAR-FTUs huggingface dataset:
Some Recent Work on the Investigation and Treatment of “Ménière's” Disease

IN a certain proportion of patients in whom vertigo occurs in association with deafness, the signs and symptoms are readily recognizable as being due to inflammatory or neoplastic processes involving the labyrinth, the VlIIth nerve or its connexions within the brain-stem. When these have been excluded there still remains a considerable group long recognized, at any rate in this country, as a well-defined clinical entity and variously referred to as Meniere's syndrome, Meni&re's disease, aural vertigo, &c. In these, the vertigo is characteristioallv paroxysmal, is often associated with nausea, vomiting, deafness and tinnitus, and occurs in the absence of any other neurological abnormalities. The histological changes in the labyrinth in two cases clinically characteristic of this group were described in 1938 (Hallpike and Cairns). Similar findings were revealed in a third case (Hallpike and Wright, 1939). Since then changes almost identical in character have been described in the affected temporal bones of all of six subjects examined in Witmaack's laboratory by Rollin (1940). Although certain differences of opinion are likdly to continue as to the precise mechanism which underlies the essential feature common to these findings, namely the endolymphatic distension, and relates it to the clinical manifestations, it seems justifiable to regard this work as establishing the morphological basis of this disorder. The clarification of existing views effected thereby takes two forms: In the first place, it has been shown that gross organic changes occur within the labyrinth and not in the VlIIth nerve, and that in type they conform with startling exactness to the state of endolvmphatic hypertension, which had been postulated by Jenkins, Portmann and others. In the second place, the remarkable uniformity in all of the cases examined of histological changes so peculiar in character suggests that they are due to a specific disease process of the labyrinth, and in this way contradicts a not uncommon but quite opposite view that the disorder could be regarded as a symptom-complex due to a wide variety of pathogenic agents acting within the labvrinth upon the sensory elements, their vascular supply or the labyrinth fluids. The present paper deals with certain results of investigations of the clinical features of this disorder which have been in progress at the National Hospital for the last two years. For the greater part the clinical material has been provided from the Out-patients' Department. All the patients suffered from paroxysmal attacks of vertigo, usually associated with deafness and tinnitus. No other neurological abnormalities were present. A blood Wassermann test was carried out in the majority and was negative in all.
Clinical and genetic heterogeneity in Omenn syndrome and severe combined immune deficiency

Abstract: OS has been described as a clinical phenotype in infants characterized by SCID, diffuse erythroderma, and other distinct features. The pathogenesis is secondary to autologous, auto‐reactive T cells produced as rare escapees from the SCID blockade. Mutations in either the RAG1 or RAG2 gene that lead to partial recombinase activity are responsible for many of the patients with these clinical features. We report on two patients, one with an atypical phenotype of OS (absence of rash but presence of other typical features) who harbored a previously undescribed mutation in RAG1, and a second who had many of the classic features of OS but was found to have a mutation in the common gamma chain (γc) cytokine receptor gene. These cases highlight the clinical and genetic heterogeneity of OS.
Prevalence of somatic alterations in the colorectal cancer cell genome

Although a small fraction of human cancers have increased rates of somatic mutation because of known deficiencies in DNA repair, little is known about the prevalence of somatic alterations in the vast majority of human cancers. To systematically assess nonsynonymous somatic alterations in colorectal neoplasia, we used DNA sequencing to analyze ≈3.2 Mb of coding tumor DNA comprising 1,811 exons from 470 genes. In total, we identified only three distinct somatic mutations, comprising two missense changes and one 14-bp deletion, each in a different gene. The accumulation of approximately one nonsynonymous somatic change per Mb of tumor DNA is consistent with a rate of mutation in tumor cells that is similar to that of normal cells. These data suggest that most sporadic colorectal cancers do not display a mutator phenotype at the nucleotide level. They also have significant implications for the interpretation of somatic mutations in candidate tumor-suppressor genes.
The Painful External Costs of Bargaining - Evidence from a Railway Strike

Evidence is presented that the number of traffic deaths and traffic injuries increased significantly due to a railway strike in Germany. While the number of slightly and seriously injured people increased on all road types, the number of fatally injured people increased only on roads out of town. The data suggest that the timing of a strike plays a crucial role in the effect on traffic injuries. Effects are stronger on weekends (Friday to Sunday) than on weekdays.
"Getting by (or getting high) with a little help from my friends": an examination of adult alcoholics' friendships.

OBJECTIVE Researchers have devoted much attention to the influence of social support on positive health outcomes, including efficacy of alcoholism treatment. Yet relatively little research has examined the structure (e.g., quantity or frequency of interactions) and quality (e.g., subjective appraisals of value or adequacy) of alcoholics' relationships. In addition, few studies have explored adult alcoholics' friendships, despite research suggesting that friendships influence treatment outcomes. The current study examined friendship characteristics of Project MATCH participants. METHOD Participants (1,183 men, 380 women) described the structure and quality of their friendships at baseline and posttreatment. Friendships with drinkers and nondrinkers were examined in relation to baseline and follow-up drinking levels, as well as participant gender, age and parental history of alcohol problems. RESULTS Significant changes were found in all aspects of friendships with both drinkers and nondrinkers from baseline to the 6-month posttreatment interview. For example, although approximately half of alcoholics friendships were with drinkers at baseline, that proportion decreased following treatment, whereas the proportion of friendships with nondrinkers increased. There was support for the hypothesis that changes in both friendship quality and structure would predict follow-up drinking levels. CONCLUSIONS This study offers persuasive evidence for the importance of quality and, especially, structure of friendships to adult alcoholics' drinking behavior. Results also suggest differences in friendships depending on gender and across the lifespan. Such individual differences may have implications for prevention and treatment.
Human molecular pathology.

Considering that it is less than 10 years since the first human genes were cloned and sequenced an enormous amount of progress has been made in unravelling the molecular pathology of genetic diseases. Reports of the isolation of human genes or linkage markers continue to pour out, and are expected to settle down to a modest 1000 a year within the next few years [1]. What is all this activity telling us about the kind of things that can go wrong with our genes? Two groups of genetic diseases, the thalassaemias and the familial hypercholesterolaemias, have already provided a mine of information about the molecular pathology of single gene disorders [2-4]. Since the globin genes were the first human genes to be cloned and sequenced, and so much was known about the genetics of thalassaemia before the availability of the new techniques of molecular biology, it is not surprising that the thalassaemias have been the subject of intensive study over the last few years. These disorders are all characterised by a reduced output of either the a or fi chains of human globin. Analysis of the structure of the genes that regulate these chains has provided us with some remarkable insights into the heterogeneity and diversity of molecular pathology. Some of the mutations that have turned up will not have surprised our colleagues in microbial genetics. Gene deletions and rearrangements are well known to them, and single base changes that scramble the genetic code, nonsense and frameshift mutations, were also to be expected. Again, we might have guessed that mutations in the promotor regions of genes, that is DNA sequences that control their rates of transcription, would also turn up in Man. But what has been surprising is the number of mutations that interfere with the processing of messenger RNA before it leaves the nucleus to become the cytoplasmic template for protein synthesis. Most mammalian genes are split into coding regions or exons, and non-coding regions called introns. When a gene is expressed the primary transcript is a large molecular weight messenger RNA precursor that contains both intron and exon sequences. While in the nucleus this molecule has to be processed so that the introns are excised and the exons spliced together. This is an extremely complex process, the molecular basis of which is only just being worked out. But what has become clear from studies of the thalassaemias is that there is an awful lot that can go wrong with it. It turns out that sequences at the junctions between exons and introns are highly conserved throughout all mammalian species and that point mutations in these regions are not compatible with any normal messenger RNA production. And some extremely novel types of mutations that involve splicing are turning up. Mutations within introns can produce alternative splicing sites and, even more subtle, mutations can occur within exons that activate cryptic splicing sites. The result of all these mutations is the production of a messenger RNA that contains intron sequences and which are therefore useless as templates for protein synthesis.
Emotional Intelligence & Job Satisfaction in IT Industry Employee

Emotional intelligence is the potential for identifying our own feelings and those of the others feeling for encouraging ourselves and in our relationships. Intelligence can be defined as abilities distinct from but modern to academic intelligence or the completely cognitive potential measured by IQ (Intelligence Quotient) as per Daniel Goleman, 1998. In reference to the above lines this paper focuses on emotional intelligence impact on performance and job satisfaction of employee in IT industry. Emotional Intelligence refers to ability to perceive, explain, evaluate and control emotion. Existing research depicts emotional intelligence can be learned and strengthened while alternate research emphasize it to be an innate feature. Keeping in view of the lags in the review of literature the authors have analyzed that impact of emotional intelligence on employee performance and job satisfaction in IT industry employee. A pilot study was done by a questionnaire with 30 variables in employees of IT Industry to see performance vis a vis the job satisfaction. Through the Model implemented a direct relation between performance and Emotional intelligence is prevalent in the IT Industry. Undoubtedly the result showed that the emotional intelligence is the positive predictor of Firm Performance.
Algorithms for scheduling hard aperiodic tasks in fixed-priority systems using slack stealing

This paper discusses the problem of jointly scheduling hard deadline periodic tasks and hard deadline aperiodic tasks using fixed priority methods. The approach is based on the slack stealing algorithm developed by the authors, and it assumes that the periodic deadlines must all be met. The paper develops a hard aperiodic acceptance test algorithm for guaranteeing tasks at any priority level, and it corrects an error in the original guarantee algorithm presented in Ramos-Thuel and Lehoczky (1993). It is shown that there is no optimal priority assignment for hard aperiodic task, but guidelines are given for choosing a good priority assignment. <<ETX>>
Cultural Sensitivity and Health Promotion: Assessing Breast Cancer Education Pamphlets Designed for African American Women

This study discusses the implications for cultural sensitivity of the rhetorical choices in breast cancer education materials developed specifically for African American audiences by national organizations. Using the PEN–3 model of cultural sensitivity as an analytic framework for a generative rhetorical criticism, this study revealed that adaptations have been made in some pamphlets to acknowledge African American cultural values related to community, self-reliance, spirituality, and distrust of the Western medical establishment, but many messages could be revised to achieve a more comprehensive, balanced, accurate, and audience-specific discussion of the breast cancer issue. Achieving cultural sensitivity in health promotion materials necessitates attention to nuanced meanings in messages, revision of questionable arguments and evidence, and avoidance of ambiguity.
New Approaches on Stability Analysis for Neural Networks with Time-Varying Delay

—Utilizing the Lyapunov functional method and combining linear matrix inequality (LMI) techniques and integral inequality approach (IIA) to analyze the global asymptotic stability for delayed neural networks (DNNs),a new sufﬁcient criterion ensuring the global stability of DNNs is obtained.The criteria are formulated in terms of a set of linear matrix inequalities,which can be checked efﬁciently by use of some standard numercial packages.In order to show the stability condition in this paper gives much less conservative results than those in the literature,numerical examples are considered.
Illustrating ontogenetic change in the dentition of the Nile monitor lizard, Varanus niloticus: a case study in the application of geometric morphometric methods for the quantification of shape–size heterodonty

Many recent attempts have been made to quantify heterodonty in non‐mammalian vertebrates, but the majority of these are limited to Euclidian measurements. One taxon frequently investigated is Varanus niloticus, the Nile monitor. Juveniles possess elongate, pointed teeth (caniniform) along the entirety of the dental arcade, whereas adults develop large, bulbous distal teeth (molariform). The purpose of this study was to present a geometric morphometric method to quantify V. niloticus heterodonty through ontogeny that may be applied to other non‐mammalian taxa. Data were collected from the entire tooth row of 19 dry skull specimens. A semilandmark analysis was conducted on the outline of the photographed teeth, and size and shape were derived. Width was also measured with calipers. From these measures, sample ranges and allometric functions were created using multivariate statistical analyses for each tooth position separately, as well as overall measures of heterodonty for each specimen based on morphological disparity. The results confirm and expand upon previous studies, showing measurable shape–size heterodonty in the species with significant differences at each tooth position. Tooth size increases with body size at most positions, and the allometric coefficient increases at more distal positions. Width shows a dramatic increase at the distal positions with ontogeny, often displaying pronounced positive allometry. Dental shape varied in two noticeable ways, with the first composing the vast majority of shape variance: (i) caniniformy vs. molariformy and (ii) mesially leaning, ‘rounded’ apices vs. distally leaning, ‘pointed’ apices. The latter was twice as influential in the mandible, a consequence of host bone shape. Mesial teeth show no significant shape change with growth, whereas distal teeth change significantly due primarily to an increase in molariformy. Overall, heterodonty increases with body size concerning both tooth size and shape, but shape heterodonty changes in the mandible are much less pronounced. Although it is unclear to what degree V. niloticus specializes in hard prey items (durophagy), previous studies of varanid feeding behavior, along with research on analogous durophagous vertebrates, indicate a division of labor along the tooth row in adults, due to a possible transition to at least a partial durophagous niche. The geometric morphometric method proposed here, although not without its own limitations, may be ideal for use with a number of dental morphotypes in the future.
Glycosaminoglycans and arterial disease.

Spend your few moment to read a book even only few pages. Reading book is not obligation and force for everybody. When you don't want to read, you can get punishment from the publisher. Read a book becomes a choice of your different characteristics. Many people with reading habit will always be enjoyable to read, or on the contrary. For some reasons, this glycosaminoglycans and arterial disease tends to be the representative book in this website.
Adaptation to use lactose in Escherichia coli.

SUMMARY: The adaptation of a genetically deficient strain of Escherichia coli (Bacterium coli) to the utilization of lactose was shown to involve overgrowth of the population by a small number of mutants. The rate of mutation to lactose utilization is about 2 x 10-7 per bacterium per generation. This rate is not influenced by lactose or a series of substances related to that sugar. The distribution of these mutants among different cultures is in agreement with that expected on the basis of random mutation. These results are discussed in connexion with the theories of Hinshelwood on bacterial adaptation, and in relation to the problem of specifically induced mutation.
Digitalization and Work Organization in New Urban Food Delivery Systems

The implementation of food distribution in general and especially within urban areas requires a state-of-the-art logistics system. One decision therein is the level of centralization, with shifting optima due to emerging digitalization and peer-to-peer concepts. This study presents insights regarding the effects of innovative food logistics solutions with digitalized logistics. Findings are based on two case studies from (1) new urban distribution systems (Foodora, Lieferando and Deliveroo) and (2) Foodsharing in Germany. Results focus on the digitalized fast and short-term coordination between suppliers, transporters and customers – with interesting influences on work organization and management of workers in food distribution.
Pay transparency

On average, women still earn less money than men in most developed countries around the world according to the OECD. In the US and UK, for example, women are paid between 82 and 85 cents for every dollar a man earns. As a potential remedy to this issue, many legislators and organisations have begun to adopt pay transparency policies. A new UK law taking effect in April 2018 requires companies with at least 250 employees to publicly disclose gender wage gap information. Going a step further toward pay transparency, Germany now allows individuals in companies with at least 200 employees to obtain median salaries for at least six comparable coworkers.
Aromatic-dependent Salmonella typhimurium as modified live vaccines for calves.

Strains of Salmonella sp with complete nonreverting aromatic biosynthesis (aro) defects are expected to be nonvirulent, in respect to invasive infection, because they need the aromatic metabolites paraaminobenzoate (for making folate) and dihydroxybenzoate (for making enterochelin) which are not available in host tissues. Derivatives with transposon-generated complete nonreverting aro-defects were prepared from 3 mouse-virulent strains of S typhimurium, namely, FIRN, WRAY, and UCD. The latter 2 parent strains originally were isolated from calves and are known to be calf-virulent. The resultant aromatic-dependent (aro-) strains were used to vaccinate 27 calves (2 to 3 weeks old), usually giving 2 doses by the IM route (10(9) bacteria) or orally (1.5 X 10(11)). Vaccination did not cause severe ill effects in any calf. Thus aro- defects cause loss of virulence for calves, as previously shown for mice. Vaccinated and control calves were challenge exposed, usually at 5 weeks of age, by feeding 1.5 X 10(11) cells of 1 of 2 calf-virulent S typhimurium strains, either UCD 108-11 or SL1323. Of the 16 challenge-exposed control calves, all became anorectic and depressed (CNS), and 15 had diarrhea. Fourteen of the 16 died; all tested tissues were bacteriologically culture-positive for Salmonella at necropsy. Vaccination with the live UCD aro- vaccine strain, SL1479 by either of 2 schedules (IM or orally) appeared effective. (ABSTRACT TRUNCATED AT 250 WORDS)
Teratogenicity of anticonvulsive medications.

The report by Feldman et al in this issue of theJournal(see p 1389) further indicts trimethadione, of the oxazolidinedione class of drugs, as one of the most potent teratogenic agents yet recognized in man. More than 80% of reported conceptuses exposed to trimethadione in utero have either been spontaneously aborted or malformed at birth. The phenotype has been similar in affected individuals and has been noted in the offspring of women who received trimethadione as the only anticonvulsant medication during pregnancy; hence the fetal trimethadione syndrome designation seems appropriate. The dysmorphic facies with a Mephistophelian upward slant to the eyebrows and the aberrant auricles appear to be the most consistent and unusual features along with mild to moderate growth deficiency. The most serious consequence is mental deficiency and the most frequent major malformations are cleft lip and/or cleft palate and cardiac defects. The concern about the teratogenic impact
Elaboration et validation d'approches en verification du locuteur

Les progres des outils de traitement du signal conjugues a une meilleure connaissance des proprietes de la parole ont recemment permis de rendre plus fiable la modelisation de ce signal et d'esperer un developpement d'applications commerciales dans ce domaine. Prealablement, il s'agit d'adapter les outils communement utilises en traitement de la parole au contexte du produit que l'on souhaite creer. Et finalement evaluer la qualite des resultats obtenus pour cet environnement d'utilisation particulier. On effectue ici une demarche de ce type pour la verification automatique de l'identite du locuteur a partir de son signal de parole. Dans ce document, on s'interesse aux aspects theoriques de notre systeme et des parametres qui entrent en jeu dans sa constitution. De l'edification de ce fond theorique on elaborera un protocole d'evaluation de nos procedes. Puis, nous abordons les aspects pratiques de sa creation. Pour finir sur deux aspects primordiaux dans l'amelioration des resultats en s'interessant aux aspects de la parametrisation du signal de parole et de l'estimation des seuils de decision.