Miracle-dz/UniFAR-FTUs huggingface dataset:
Arginine-induced insulin release in relation to the cyclic AMP system in man.

The insulin-releasing action of the amino acid arginine in man is inhibited by hypoglycemia. Furthermore, arginine potentiates glucose-induced insulin release, probably by amplifying the insulinogenic signal evoked by glucose in the beta-cell. The beta-adrenergic blocking agent propranolol, in doses known to suppress glucose-induced insulin release, did not alter insulin response to arginine infusion. Arginine markedly augments insulin release secondary to glucose whereas, under the same experimental conditions, it has no effect on insulin release secondary to glucagon. Finally, pretreatment with aminophylline potentiated the insulinogenic potency of the amino acid. We have previously postulated that glucose elicits insulin release by acting directly on a specific cell membrane receptor. The signal thus evoked is probably mediated through the adenyl cyclase-cyclic AMP system. In the light of this hypothesis and the above results we suggest that arginine acts on the beta-cell by amplifying the transmission.
Naproxen-Induced Anemia and Hypoalbuminemia in a 16-Month-Old Child

The effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the stomach and duodenum are widely recognized. However, the gastrointestinal toxicity is not restricted to these sites; it is now understood to extend to the small intestine, colon, and rectum. Cases involving anemia and hypoalbuminemia secondary to NSAIDs have been described in adults, but to the best of our knowledge not in children. We present a case of a 16-month-old child with oligoarticular juvenile idiopathic arthritis (JIA) receiving naproxen for more than 3 months, who presented to our tertiary care pediatric hospital with hypoalbuminemia, generalized edema, and iron deficiency anemia (IDA).
PTEN (MMAC1) Mutations Are Frequent in Primary Glioblastomas (de novo) but not in Secondary Glioblastomas

Loss of heterozygosity (LOH) on chromosome 10 is the most frequent genetic alteration associated with the evolution of malignant astrocytic tumors and it may involve several loci. The tumor suppressor gene PTEN (MMAC1) on chromosome 10q23 is mutated in approximately 30% of glioblastomas (WHO Grade IV). In this study, we assessed the frequency of PTEN mutations in primary glioblastomas, which developed clinically de novo, and in secondary glioblastomas, which evolved from low-grade (WHO Grade II) or anaplastic astrocytomas (WHO Grade III). Nine of 28 (32%) primary glioblastomas contained a PTEN mutation and an additional case showed a homozygous PTEN deletion. This indicates that after overexpression/ amplification of the EGF receptor, loss of PTEN function is the most common alteration in primary glioblastomas. In this series, 5 of 28 (18%) primary glioblastomas showed both a PTEN mutation and EGFR amplification. In contrast, only 1 of 25 (4%) secondary glioblastomas contained a PTEN mutation, and none of them showed a homozygous PTEN deletion. The secondary glioblastoma with a PTEN mutation developed from an anaplastic astrocytoma that already carried the mutation. The observation that secondary glioblastomas have a p53 mutation as a genetic hallmark but rarely contain a PTEN mutation supports the concept that primary and secondary glioblastomas develop differently on a genetic level.
Criteria for physical dimensions of MIMO OTA multi-probe test setup

This paper discusses requirements for physical dimensions of an anechoic chamber and fading emulator based MIMO over the air (OTA) test set-up. The purpose is to find an answer to the question of how large devices can be measured with certain accuracy for given dimensions of a ring of OTA antennas and a given range of frequencies. Criteria for physical dimensions are developed based on field strength stability across the test zone and phase stability across the test zone. As a reference also the CTIA minimum measurement distance criteria are presented. It is found that the ratio of the radius of a test area and the radius of a ring of OTA antennas has to be 0.1 or lower on a frequency range of 0.5 to 6 GHz.
Cartoon and Texture Decomposition-Based Color Transfer for Fabric Images

A color design process for fabric images can resort to a solution of a color transfer problem based on given color themes. Usually, the color transfer process contains an image segmentation phase and an image construction phase. In this paper, a novel color transfer method for fabric images is proposed. Compared with classical color transfer methods, the new method has the following three main innovations. First, the new method, in its image segmentation phase, follows an assumption that a fabric image can be decomposed into cartoon and texture components, which means the new color transfer method, in its image segmentation, phase incorporates an image decomposition process. The advantage of the innovation is that the cartoon component is more suitable than the original image to be used to partition the fabric image. Second, the new color transfer method can generate more vivid color transfer results since the above texture component is used to describe yarn texture details in the image construction phase. Third, the total generalized variation (TGV) regularizer is used to further improve the performance of image decomposition. Here, the TGV regularizer is good at estimating the weak lightness variation of the cartoon component with the CIELab color scheme. In addition, by using the augmented Lagrange multiplier method, we derive an efficient algorithm to search for the solutions to the proposed color transfer problem. Numerical results demonstrate that the proposed color transfer method can generate better results for fabric images.
Building Functional Connectivity Neuromarkers of Behavioral Self-Regulation in Children with and without Autism Spectrum Disorder

Children with Autism Spectrum Disorder (ASD) are known to struggle with behavioral self-regulation, which associates with greater daily-life challenges and an increased risk for psychiatric comorbidities. Despite these negative outcomes, little is known about the neural expression of behavioral regulation in children with and without ASD. Here, we examined whole-brain linear associations between brain functional correlations (FC) and behavioral regulation through connectome predictive modelling (CPM), a data-driven protocol for developing predictive models of brain–behavior relationships from data, assessing ‘neuromarkers’ using cross-validation. Using data from two sites of the ABIDE II dataset comprising 276 children with and without ASD (8-13 years), we identified functional brain networks whose FC predicted individual differences in two, of three, behavioral regulation subdomains. These distributed network models predicted novel individuals’ inhibition and shifting from resting-state FC data both in a leave-one-out, as well as split halves, cross-validation. We observed commonalities and differences in the functional networks associating with these subdomains, with inhibition relying on more posterior networks, shifting relying on more anterior networks, and both involving regions of the DMN. Our findings present a substantial addition to our knowledge on the neural expressions of inhibition and shifting across the spectrum of children with and without ASD, demonstrating the utility of this trans-diagnostic modelling approach. Given the numerous cognitive and behavioral issues that can be quantified dimensionally in neurodevelopmental disorders, further refinement of whole-brain neuromarker techniques may thus pave a way for functional neuroimaging to meaningfully contribute to individualized medicine.
Which constructs can predict emotional exhaustion in a working population? A study into its determinants

The main objective of this study was to examine the psychosocial stress model developed by Taylor and Aspinwall with emotional exhaustion as the outcome variable. Respondents, 409 men and 346 women, who had a paid job for at least 20 hours per week, completed questionnaires concerning demographic variables, personality, temperament, work pressure, workload, perceived social support, appraisal, coping, and emotional exhaustion. Structural equation analyses provided only partial support for the validity of the model. First, on theoretical and statistical grounds, one more path linking external resources to social support was added. Second, contrary to expectations, coping styles did not predict emotional exhaustion. To conclude, when coping is measured retrospectively, it does not add to our understanding of emotional exhaustion. It is suggested that future studies should be longitudinal and include objective measures of stressors and psychosocial health outcomes in addition to self-reports. Copyright © 2007 John Wiley & Sons, Ltd.
Immunmodulation durch IPSE/alpha-1, ein exkretorisch-/sekretorisches Protein aus Schistosoma mansoni-Eiern

Infektionen mit Helminthen konnen den Wirt vor der Entwicklung chronisch-entzundlicher Erkrankungen schutzen. So ist bei S. mansoni das Ei-Stadium immunregulatorisch wirksam. Die zahlreich in den Mesenterialvenen des Wirts abgelegten Eier wandern durch das Darmepithel in das Darmlumen und induzieren Granulome. Sie schadigen die Blutgefas- und Darmwand und eroffnen damit Eintrittspforten fur intestinale Mikrobiota. Hier scheint IL-4 essentiell fur die Entzundungskontrolle zu sein: IL-4- und IL-4Rα-defiziente Mause versterben bei einer Schistosomen-Infektion rasch an einer exzessiven Darmentzundung. Beachtlich ist, dass die Eier ein Glykoprotein, IPSE/alpha-1, sezernieren, welches Basophile zur Freisetzung von IL-4 stimuliert. Die Frage war: Ist IPSE/alpha-1 uber die Induktion von basophilem IL-4 an der Suppression einer uberschiesenden intestinalen Entzundung im Zuge einer Infektion mit S. mansoni beteiligt? In der Kokultur hemmten IPSE/alpha-1-aktivierte humane Basophile IL-4-vermittelt und zellkontaktunabhangig die Freisetzung proinflammatorischer Zytokine (IL-1β, IL-6 und TNF) aus LPS-aktivierten Monozyten – auch im Kontext mit PBMC. Die simultane Stimulation der Basophilen uber FceRI-gebundenes IgE (via IPSE/alpha-1) und uber TLR4 (via LPS) fuhrte zu einer synergistisch erhohten IL-4-Freisetzung. Ferner entwickelten die inflammatorischen Monozyten in Gegenwart der aktivierten Basophilen einen M2-typischen antiinflammatorischen Phanotyp mit erhohter Expression von CD206 und CD209. Mittels immunhistologischer Untersuchungen an Geweben S. mansoni-infizierter Mause konnten zudem Basophile in Ei-Granulomen in Darm und Leber nachgewiesen werden, womit von den Schistosomen-Eiern sezerniertes IPSE/alpha-1 unmittelbar auf die Basophilen wirken konnte. Insgesamt unterstutzen diese Daten die Hypothese, dass IPSE/alpha-1 und Basophile zusammen mit LPS substantiell an der durch S. mansoni-Eier vermittelten intestinalen Entzundungskontrolle beteiligt sein konnten.
Rat models in peritoneal dialysis.

BACKGROUND It is widely accepted that the currently used dialysis solutions are not biocompatible with the peritoneal membrane. Therefore, animal studies have been performed to study different aspects of peritoneal dialysis. However, representative models mimicking the human situation are not yet available. METHODS The effect of a single injection of peritoneal dialysis (PD) fluid on the cellular composition was studied. Thereafter, the effect of a single injection of PD fluid on bacterial clearing was tested over time. Finally, an in vivo rat model was established to study the effects of long-term exposure to PD fluid on the peritoneal membrane and the local host defence (peritoneal cells). RESULTS In the rat model, long-term daily exposure is possible. The 'drop-out' after 9-10 weeks on the most commonly used PD fluid Dianeal 3.86%, however, is approximately 50% due to omental wrapping. In the remaining study group, large differences were observed (as compared with controls), especially with respect to morphological parameters. CONCLUSIONS The rat peritoneal continuous exposure model seems to have potential for intervention studies, since it uses no additions, no antibiotics and no omentomectomy, and gives continuous long-term exposure to PD fluid. However, problems still remain: 'drop-out' is quite often seen and this non-uraemic exposure model does not totally mimic the situation present in continuous ambulatory PD patients.
Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin

Conformational changes are thought to underlie the activation of heterotrimeric GTP-binding protein (G protein)—coupled receptors. Such changes in rhodopsin were explored by construction of double cysteine mutants, each containing one cysteine at the cytoplasmic end of helix C and one cysteine at various positions in the cytoplasmic end of helix F. Magnetic dipolar interactions between spin labels attached to these residues revealed their proximity, and changes in their interaction upon rhodopsin light activation suggested a rigid body movement of helices relative to one another. Disulfide cross-linking of the helices prevented activation of transducin, which suggests the importance of this movement for activation of rhodopsin.
Modelling of body temperature in rats : circadian rhythm , chemically induced hypothermia and tolerance development Master ’ s degree project

A mechanism-based pharmacokinetic/pharmacodynamic (PK/PD) model was developed to describe body temperature in untreated and CmpX-treated rats. The model included CmpX exposure levels, normal circadian rhythm, CmpX-induced hypothermia, tolerance development and temperature increases during animal handling. Model fitting and validation was performed with data from two experiments with different routes of administration.
Adolescent females' strategic behavior within romantic relationships

Three romantic strategies are inferred from an evolutionary life-history model of adolescence, in which girls must choose between beginning reproduction and acquiring skills. These strategies differ in the level of commitment sought and in the type of information gathered during relationships. I surveyed 158 heterosexual high school girls in New Mexico. The three strategies, as well as age, sexual maturity, parents' education, and father absence, were used as predictors of romantic relationship duration. Three significant results were obtained using the Cox Proportional Hazards Model. First, girls scoring high in the “committer” scale were less likely to have relationships end than were girls scoring higher on “information-gatherer” scales. Also, Anglo girls and Anglo-Hispanic multi-racial girls were more likely to have a relationship end than were Hispanic girls. Third, girls from a higher socioeconomic background were likely to have longer relationships. The implications of these results are discussed.
The application of wavelet theory with denoising to estimate the parameters of earthquake

In this paper, strong ground mot (SGM) parameters are calculated using discrete wavelet transform (DWT) in different kinds of soils with different magnitudes. The main earthquake record (MER) is divided into approximation and detailed signals using wavelet transform with denoising. The high and low frequencies of MER are separated from each other. Previous studies showed that the approximation signal has the greatest effect on dynamic response and it is very similar to the main signal. Then SGM parameters of the new signal are calculated by DWT decomposition. This process continues over five levels and, in each level, SGM parameters are calculated and compared with the MER and its error percentage is presented. In DWT with the denoising method, the curve becomes softer such that the calculation time reduces. Results show that the error percentage in the first two levels is less than 1% and for the third level, this index is less than 3%. In addition, the reduction percentage of calculation time is 1%, 4%, and 8%, respectively, in the first to third levels. The best result is relative to the third decomposition level in which error value as well as computational time reduction is nearly 3% and 8%.
Cross‐bridge detachment and sarcomere 'give' during stretch of active frog's muscle.

1. A study has been made of the tension responses and sarcomere length changes produced by servo‐controlled stretches applied to isometrically contracting frog muscle. Sarcomere lengths were monitored by cine‐photography of diffiraction spectra obtained by illuminating a small area of muscle with a laser. 2. The tension increment produced by a ramp‐and‐hold stretch of approximately 1 mm (ca. 4% of the muscle length) comprises three phases whose limits are defined by two points, S1 and S2, where the slope of the response decreases abruptly. S1 and S2 correspond to extensions of 0.13 and 1.2% of the muscle length. 3. Movements of the first order spectra relative to the zero order recorded during stretch reveal that S2 coincides with an abrupt elongation of the sarcomeres. This is termed sarcomere 'give' and it occurs when the filaments are displaced by 11‐12 nm from their steady‐state (isometric) position. 4. The stiffness of the sarcomeres, Es, up to S2 decreases with increasing sarcomere length. The maximum force sustained by the muscle at S2, PS2, also shows an inverse dependence on sarcomere length. Both Es and PS2 fall to zero at an extrapolated sarcomere spacing of 3.6‐3.7 micrometer, coinciding with the length at which the actin and myosin filaments no longer overlap. 5. The ratio PS2/P0 (where P0 = maximum isometric tension) varies with temperature and speed of stretch. It increases with increasing speeds of stretch until a certain critical velocity, Vc, is reached, beyond which it is almost independent of any further increase. Vc has a positive temperature coefficient, increasing 5‐6 in the range 0‐30 degrees C (Q10 = 1.8). There is a positive correlation between the maximum speed of isotonic shortening (Vmax.) and Vc in different muscles. 6. Sarcomere 'give' during stretch is considered to be due to forcible detachment of cross‐bridges between the actin and myosin filaments. This results in recoil of the extended series elastic elements in the muscle at the expense of the sarcomers. The amount of filament displacement required to induce sarcomere 'give' (11‐12 nm) is thought to represent the range of movement over which a cross‐bridge can remain attached to actin during a stretch.
The clinical study of secondary cytoreductive surgery in the treatment of low grade serous ovarian cancer

Objective: To investigate the therapeutic effect of secondary cytoreductive surgery in the patients with low grade serous ovarian cancer and to analyze the influence of the postoperative quality of life. Method: We collected the clinical data of patients with low grade serous carcinoma who underwent secondary cytoreductive surgery in our hospital from January 2003 to January 2015, and performed a retrospective analysis. We collected the basic data of patients, survival information, chemotherapy and disease related characteristics. We recorded the patient’s postoperative treatment, overall survival (OS), disease-free survival (DFS) and death situation, and evaluated the quality of life of patients before and after the secondary cytoreductive surgery according to European organization for research and treatment of cancer quality of life questionair (EORTC QLQ-C30). Results: A total of 50 patients with low grade ovarian cancer were enrolled in this study. There were 39 patients (78%) with grogs residual disease (GRD) among the 50 patients. The median DFS was 57.4 months and 14.9 months respectively for patients without and with GRD. The median OS was 92.9 months and 70.4 months respectively for patients without and with GRD. The Cox multivariate regression analysis showed that the risks of survival with disease and death in patients with GRD were 3.27 and 2.04 times greater than who without GRD. The results were applied comparative t-test and showed that the postoperative quality of life was better than that preoperative in patients (P<0.05). Conclusion: Whether the secondary cytoreductive surgery is performed thoroughly or not is closely related to the disease-free survival and overall survival of patients with low grade serous ovarian cancer. The implementation of secondary cytoreductive surgery is helpful to improve the quality of life of patients.
XTV: a framework for sharing X Window clients in remote synchronous collaboration

XTV is a distributed system for sharing X Window applications synchronously among a group of remotely located users at workstations running X and interconnected by the Internet. The major components of the system are designed and implemented in such a way that make them reusable in other collaborative systems and applications. A description is presented of the fine technical details and knowledge required to understand and replicate the work which went into developing XTV. The following concepts are discussed: interception, distribution and translation of traffic between X clients and display servers; regulation of access to tools using a token passing mechanism and reverse-translation of server traffic; and accommodation of systems with different architectures which may have different byte orders for integer representation. <<ETX>>
Damage engineered Se implant for NMOS TiSix contact resistivity reduction

Low specific contact resistivity (7E-9 Ohm.cm2) was achieved for contacts with TiSix to in-situ epitaxially doped Si:P n-SD regions by use of Se implantation prior to Ti deposition. The key to this achievement is the optimization of implant energy and dose, and use of millisecond laser anneal to heal the implant damage, while allowing sufficient inter-mixing of Ti, Si, Se and P atoms across a smooth TiSix/Si:P interface, to realize the SBH-lowering benefits of Se.
The effects of virtual and augmented learning environments on the learning process in secondary school

Pedagogy is in a dire need of shift since students are under motivated. Virtual and augmented reality offer great solutions given the fact that the majority of high school students have heard of those. Augmented reality based applications such as the Pokémon Go 3D has proven that smartphone applications are capable of exciting and moving people therefore these can be used effectively in education.
Nitrogen Oxide Reactions in the Urban Plume of Boston

The rate of removal or conversion of nitrogen oxides has been determined from airborne measurements in the urban plume of Boston. The average pseudo-first-order rate constant for removal was 0.18 per hour, with a range of 0.14 to 0.24 per hour under daylight conditions for four study days. The removal process is dominated by chemical conversion to nitric acid and organic nitrates. The removal rate suggests an atmospheric lifetime for nitrogen oxides of about 5 to 6 hours in urban air.
A Novel Recommendation System for Dental Services Based on Online Word-of-Mouth

Electronic word of mouth eWoM is one of the most valuable resources available to consumers in the search for products and services. This paper presents a novel recommendation system in which eWoM citations compiled using search engines are filtered according to the preferences and requirements of users. The proposed mechanism uses descriptive term creation to formalize the language used in searches, which is then classified according to the Rational Decision Making model to facilitate the analysis of eWoM. The proposed system was evaluated by applying it to the search for dental services in Chungli, Taiwan. Experiment results show that the proposed system reduces the time and effort required to sift through search results. Participants reported that the proposed system excels in quality and effectiveness and had a positive effect on their satisfaction and behavioral intentions. From a managerial perspective, the proposed system provides a valuable tool with which to improve service quality by identifying areas in which previous users have provided negative commentary via eWoM.