Miracle-dz/UniFAR-FTUs huggingface dataset:
Health-related quality of life one month after thrombolysis or primary PCI in patients with ST-elevation infarction. A DANAMI-2 sub-study.

Objectives. To evaluate the health-related quality of life (HRQoL) following Primary percutaneous coronary intervention (PCI) or thrombolytic treatment for ST-elevation myocardial infarction (STEMI). Design. A questionnaire based study on patients randomised in the DANAMI-2 study to Primary PCI or thrombolysis for STEMI. A total of 1 351 patients (93.2% response rate) randomised in the DANAMI-2 study completed the HRQoL questionnaire one month after the infarction. Results. With respect to the primary end-points (SF-36 physical component score, angina pectoris, and dyspnoea), patients randomised to primary PCI scored better on the SF-36 physical component score (PCS) (p = 0.007), and reported significantly less angina pectoris (p = 0.010) and dyspnoea (p = 0.010). Higher scores among PCI patients were also found on the SF-36 scales physical functioning (p = 0.015), role-physical (p = 0.017), and general health (p = 0.009). Conclusion. The results in this study support the hypothesis that primary PCI is superior to thrombolysis in treating STEMI, not only in clinical outcome, but also in quality of life outcome.
CMOS-compatible micromachined edge-suspended spiral inductors with high Q-factors and self-resonance frequencies

This paper reports a new category of high-Q edge-suspended inductors (ESI) that are fabricated using CMOS-compatible micromachining techniques. This structure was designed based on the concept that the current was crowded at the edges of the conducting metal wires at high frequencies due to the proximity effect. The substrate coupling and loss can be effectively suppressed by removing the silicon around and underneath the edges of the signal lines. Different from the conventional air-suspended inductors that have the inductors built on membranes or totally suspended in the air, the edge-suspended structures have the silicon underneath the center of the metal lines as the strong mechanical supports. The ESIs are fabricated using a combination of deep dry etching and anisotropic wet etching techniques that are compatible with CMOS process. For a three-turn 4.5-nH inductor, a 70% increase (from 6.8 to 11.7) in maximum Q-factor and a 57% increase (from 9.1 to 14.3 GHz) in self-resonance frequency were obtained with a 11-/spl mu/m suspended edge in 25-/spl mu/m-wide lines.
The microanatomy of T‐cell responses

Summary: The priming of a T cell results from its physical interaction with a dendritic cell (DC) that presents the cognate antigenic peptide. The success rate of such interactions is extremely low, because the precursor frequency of a naive T cell recognizing a specific antigen is in the range of 1:105–106. To make this principle practicable, encounter frequencies between DCs and T cells are maximized within lymph nodes (LNs) that are compact immunological projections of the peripheral tissue they drain. But LNs are more than passive meeting places for DCs that immigrated from the tissue and lymphocytes that recirculated via the blood. The microanatomy of the LN stroma actively organizes the cellular encounters by providing preformed migration tracks that create dynamic but highly ordered movement patterns. LN architecture further acts as a sophisticated filtration system that sieves the incoming interstitial fluid at different levels and guarantees that immunologically relevant antigens are loaded on DCs or B cells while inert substances are channeled back into the blood circulation. This review focuses on the non‐hematopoietic infrastructure of the lymph node. We describe the association between fibroblastic reticular cell, conduit, DC, and T cell as the essential functional unit of the T‐cell cortex.
Role of interleukin-6 in cachexia: therapeutic implications

Purpose of reviewInterleukin-6 (IL-6) has emerged as a cytokine involved in cachexia progression with some cancers. This review will present the recent breakthroughs in animal models and humans related to targeting IL-6 as a cancer cachexia therapy. Recent findingsIL-6 can target adipose, skeletal muscle, gut, and liver tissue, which can all affect cachectic patient recovery. IL-6 trans-signaling through the soluble IL-6R has the potential to amplify IL-6 signaling in the cachectic patient. In the skeletal muscle, chronic IL-6 exposure induces proteasome and autophagy protein degradation pathways that lead to wasting. IL-6 is also indirectly associated with AMP-activated kinase (AMPK) and nuclear factor kappa B (NF-&kgr;B) activation. Several mouse cancer models have clearly demonstrated that blocking IL-6 and associated signaling can attenuate cachexia progression. Additionally, pharmaceuticals targeting IL-6 and associated signaling can relieve some cachectic symptoms in cancer patients. Research with cachectic mice has demonstrated that exercise and nutraceutical administration can interact with chronic IL-6 signaling during cachexia progression. SummaryIL-6 remains a promising therapeutic strategy for attenuating cachexia progression with many types of cancer. However, improvement of this treatment will require a better understanding of the indirect and direct effects of IL-6 as well as its tissue-specific actions in the cancer patient.
Modulation of mitochondrial respiration by nitric oxide: investigation by single cell fluorescence microscopy

With the electro‐driven import of rhodamine 123, we used single cell fluorescence microscopy to single out the contribution of nitric oxide (NO) in controlling mitochondrial membrane potential expressed by (stationary growing) rhabdomyosarcoma and neuroblastoma cells in culture. The experimental design and the computer‐aided image analysis detected and quantitated variations of fluorescence signals specific to mitochondria. We observed that 1) the two cell lines display changes of fluorescence dependent on mitochondrial energization states; 2) mitochondrial fluorescence decreases after exposure of the cells to a NO releaser; 4) the different fluorescence intensity measured under stationary growing conditions, or after activation and inhibition of constitutive NO synthase, is consistent with a steady‐state production of NO. Direct comparison of single cell fluorescence with bulk cytofluorimetry proved that the results obtained by the latter method may be misleading because of the intrinsic‐to‐measure lack of information about distribution of fluorescence within different cell compartments. The kinetic parameters describing the reactions between cytochrome oxidase, NO, and O2 may account for the puzzling (20‐fold) increase of the KM for O2 reported for cells and tissues as compared to purified cytochrome c oxidase, allowing an estimate of in vivo NO flux. —Sarti, P., Lendaro, E. , Ippoliti, R. , Bellelli, A. , Benedetti, P. A. , Brunori, M. Modulation of mitochondrial respiration by nitric oxide: investigation by single cell fluorescence microscopy. FASEB J. 13, 191–197 (1999)
GIS Approach for Collaborative Monitoring and Prediction of Environmental Noise in Urban areas

Environmental noise, as well as being a form of environmental pollution that affects mainly urban areas, it is a problem that involves people's quality of life. This paper presents a methodology that takes advantage of the Volunteered Geographic Information (VGI) in obtaining georeferenced environmental noise maps and the corresponding statistics for a particular area of interest. The methodology herein presented considers the phases of Data acquisition, Analysis and data processing, and Visualization of the information. The design and development of a Geographic Information System is presented, which consists of a web mapping application, an application for mobile devices, called NoiseMonitor, Geospatial Analysis and Machine Learning methods (Support Vector Machines and Artificial Neural Networks) for acoustic noise prediction using contextual information, that is, some factors around the measurements. A study case is based on Mexico City.
The litter size in chromosomally polymorphic blue foxes.

Makinen, A. and Lohi, O. 1987. The litter size in chromosomally polymorphic blue foxes. —Hereditas 107:115–119. Lund, Sweden. ISSN 0018–0661. Received December 10, 1986 About 50 % of the Finnish farm bred blue foxes have a Robertsonian translocation in a heterozygous form, whereas the distributions of the homozygous form 2n = 48 and the 2 n = 50 karyotype with two acrocentric autosome pairs seem to be nearly equal. The effect on fertility exerted by the heterozygous Robertsonian translocation was studied on the material from a blue fox farm in Finland during four years. It is concluded that there is a tendency to litter size reduction in mating groups 2n = 49 compared to the 2n = 48 and 2n = 50 mating groups. In this investigation, the 2n = 48 chromosome constitution in parental blue fox groups has every year had a slight tendency to increase the litter size. In addition, the segregation of the karyotypes within the litters of the parental 2n = 49 mating groups is in favour of the 2n = 48 karyotype. Hence, an evolutional tendency towards lower chromosome number without any acrocentric autosomes seems to be indicated.
Proposal of Burkholderia gen. nov. and Transfer of Seven Species of the Genus Pseudomonas Homology Group II to the New Genus, with the Type Species Burkholderia cepacia (Palleroni and Holmes 1981) comb. nov.

Based on the 16S rRNA sequences, DNA‐DNA homology values, cellular lipid and fatty acid composition, and phenotypic characteristics, a new genus Burkholderia is proposed for the RNA homology group II of genus Pseudomonas. Seven species in this group were transfered to the new genus. Thus seven new combinations, Burkholderia cepacia (Palleroni and Holmes 1981), Burkholderia mallei (Zopf 1885), Burkholderia pseudomallei (Whitmore 1913), Burkholderia caryophylli (Burkholder 1942), Burkholderia gladioli (Severini 1913), Burkholderia pickettii (Ralston et al 1973) and Burkholderia solanacearum (Smith 1896) were proposed.
Overeducation in the Labour Market

This paper presents a review of the literature on overeducation. The paper assesses the consistency of overeducation within the context of a number of theoretical frameworks including Human Capital Theory "HCT" and Assignment Theory. The analysis goes on to discuss the various measurement controversies associated with the study of overeducation in order to provide an assessment of the extent to which the impacts of the phenomenon represent an economic reality as opposed to a statistical artefact. After reviewing the literature, it is concluded that the impacts of overeducation are likely to be non-trivial and that the phenomenon may potentially be costly to individuals and firms, as well as the economy more generally. The existence of overeducation also raises some doubts with respect to the validity of some of the central assumptions and predictions of HCT that are unlikely to be fully explained by gaps in the standard wage equation framework. Copyright Blackwell Publishers Ltd, 2006.
DNA replication timing: Coordinating genome stability with genome regulation on the X chromosome and beyond

Recent studies based on next‐generation DNA sequencing have revealed that the female inactive X chromosome is replicated in a rapid, unorganized manner, and undergoes increased rates of mutation. These observations link the organization of DNA replication timing to gene regulation on one hand, and to the generation of mutations on the other hand. More generally, the exceptional biology of the inactive X chromosome highlights general principles of genome replication. Cells may control replication timing by a combination of intrinsic replication origin properties, local chromatin states and global levels of replication factors, leading to a functional separation between the activity of genes and their mutation.
BER performance of CC-OFDM system with NNLMS equalization technique

This work investigates a technique of high data transmission rate over wireless communication system. Now a day's higher bandwidth demand has been increased and with the minimum tolerance of error. To enhance available bandwidth and improve the quality of transmission convolution codes are used on the OFDM (Orthogonal frequency division multiplexing) wireless communication system over AWGN channel. The main objective is to transmit the data with low bit error rate in the noisy environment. Convolution coding based OFDM systems with channel equalization (CC-OFDM-CE) is used to reduce bit error rate & to overcome the distortions caused by phenomena like fading, delay spread and multipath effect. This work investigated the OFDM system performance for uncoded channel equalization using quadrature amplitude modulation (QAM) and BPSK. To further enhance the system, convolutional coding employed to OFDM system with channel equalization.
A renaissance for cardio‐metabolic surgery: better outcomes and lower costs?

Not too long ago surgeons routinely treated metabolic problems including hypertension, hyperlipidaemia and obesity. However, these areas declined as drug therapies became available and surgical approaches lost favour due to high rates of perceived complications. Surgery survived in specialist metabolic oncological applications for treatment of endocrine adenomas or carcinomas. Metabolic endocrine surgery has grown ever more sophisticated with better imaging, more sensitive sampling techniques, intra-operative endocrine monitoring using point-of-care assay technologies and the increasing use of minimal access and eventually robotic surgery techniques (1-3). The diagnosis of primary hyperparathyroidism (PHPT) is more frequently made at a significantly earlier stage than in the past. Surgery is performed for both prognostic benefit and symptom relief. Surgical approaches have evolved rapidly in recent years with an evolution in minimally invasive procedures aided by improvements in pre-operative localisation (4). Day surgery procedures are common and intra-operative assays of parathyroid hormone can be used to confirm surgical success in minutes. Type II calcimimetic drugs that enhance the sensitivity of the calcium-sensing receptor to calcium resuting in a decrease in PTH secretion are used in secondary hyperparathyroidism reducing the need for surgery in some patients (5), and may also have a selective role in complicated patients with PHPT and malignancy. In other areas surgery disappeared such as when initially H2 antagonists and later proton pump inhibitors (PPIs) replaced the need for gastric acid reduction by vagotomy.
Physical Attractiveness, Attitudes toward Career, and Mate Preferences among Young Chinese Women

We examined young Chinese women's mate preferences as a function of their self-perceived attractiveness and career attitudes. A total of 264 young Chinese women rated their own attractiveness, reported their attitudes toward career, and rated the importance of 20 mate characteristics. The characteristics encompassed four facets that individuals typically consider when seeking a long-term mate: good-genes indicators, good investment ability indicators, good parenting indicators, and good partner indicators. We found that both self-perceived attractiveness and attitudes toward career were positively associated with the importance attached to several of the characteristics. Moreover, women who had high career focus but low self-perceived attractiveness attached more value to intelligence, ambition, and industriousness than women who had low career focus but high self-perceived attractiveness; women with low career focus but high self-perceived attractiveness attached more value to physical attractiveness in a mate than women with high career focus but low self-perceived attractiveness. We discussed the limitations of our research and directions for future research.
The increase in plasma progesterone levels in the pregnant guinea-pig and its possible significance.

Plasma progesterone concentrations in the pregnant guinea-pig are greater than in many species and far higher than those found in the normal cycle The present experiments were intended to compare the effects of subcutaneous progesterone tablets on plasma progesterone levels after ovariectomy with those in normal, non-pregnant and pregnant females. The ovaries are essential for pregnancy in most guinea-pigs between about Days 14 and 28 but from about Day 28 pregnancy will continue normally without exogenous hormones owing to the production of placental progesterone. In this study it was decided to use females in the 1st month of pregnancy when the actual production of progesterone by the placenta is far less than that of the ovary and is well below that reached in later stages (Heap & Deanesly, 1966).
Quantitative minimization for liftoff distance variation using radial basis function network on eddy current nondestructive testing

This paper presents a technique to evaluate liftoff characteristics on zirconium weld metal using the impedance signals collected by ferrite pot core probe. The inspection system uses sine waveform as the excitation source of a multi-line coil and captures the transient fields associated with the induced eddy currents via a sensor. The collected signals by 1mm increment of distance can be divided into training and testing data in radial basis function network that was developed to estimate the accuracy for liftoff distance effect. The proposed approach of radial basis function network has been successfully developed to evaluate liftoff distance effect on test samples. Keyword-Eddy current probe, zirconium weld metal, ferrite pot core, liftoff, RBF network
Comparison of some dietary habits on corrosion behavior of stainless steel brackets: an in vitro study.

BACKGROUND AND OBJECTIVE Resistance to corrosion is an advantageous property of orthodontic brackets; however, due to low levels of pH found in the mouth of a patient, localized corrosion may occur This can affect tooth movement by increasing friction between the arch wire and bracket slot and initiate enamel discoloration. Additionally, corrosion causes the release of elements that may lead to cytotoxic and biological side effects. The aim of this study was to compare the amount of corrosion caused by lemon juice, vinegar and Coca-Cola on orthodontic brackets in vitro and then to recommend the most suitable diet during orthodontic treatment. METHOD Sixty orthodontic brackets in three groups of twenty were immersed in a test solution (Fusamaya-Meyer artificial saliva plus lemon juice, vinegar or Coca-Cola) at a temperature of 37 degrees C +/- 1. Moreover, a negative control consisting of twenty brackets were put in pure artificial saliva. After 6 weeks the amount of corrosion was determined by measuring delta W of mean weights of brackets and the results were analyzed by general linear models (repeated measurement). RESULTS Significant differences were seen during different weeks of the study (P < 0.001) and different solutions (P < 0.001). This study showed the amount of corrosion in orthodontic brackets was the most for cola followed by vinegar and then lemon juice. In addition, mean differences for cola versus lemon juice was -0.010 (sig. <0.001), vinegar versus lemon juice was -0.006 (sig. = 0.001) and cola versus vinegar was -0.004 (sig. = 0.013). CONCLUSION Acidic effervescent soft drinks such as cola have to be eliminated or minimized in the nutritional diet of orthodontic patients because of their harmful effects on their brackets.
Gene expression and gene associations during the development of heart failure with preserved ejection fraction in the Dahl salt sensitive model of hypertension

ABSTRACT Gene expression and associations were examined in a model of heart failure with preserved ejection fraction (HFpEF), a condition with minimal effective treatment. Genes with at least two studies showing significant changes in Dahl rat with heart failure were examined by meta-analysis. Significantly increased in expression were iNOS, p47phox, ADM, ANP, OPN, ACE, MCP-1, GP91PHOX, ICAM-1, TGF-β1, CTGF, ET-1, p22phox, ETB, BNP, ETA, MMP13, Col1a1, MMP2, TIMP1, Col3a1, Il-1β, β-MHC, ECE1, MMP14, AGT, and MMP9. In contrast, GLUT4, VEGF, eNOS, HIF-1α, and PGC1-α were significantly decreased in expression. The top biological process clusters identified in Database for Annotation, Visualization and Integrated Discovery, ToppGene, and PANTHER were collagen metabolic process, cellular ion homeostasis, regulation of cell migration, and response to decreased oxygen levels. These data suggest refocusing understanding of the pathophysiology of HFpEF to pathways involved in collagen metabolism, cell migration likely for inflammatory cells, and responses to decreased oxygen levels. Abbreviations Inducible nitric oxide synthase (INOS), neutrophil cytosolic factor 1 (p47phox), adrenomedullin (ADM), atrial natriuretic peptide (ANP), osteopontin (OPN/SPP1), angiotensin converting enzyme (ACE), monocyte chemotactic protein 1 (MCP-1), cytochrome b-245 beta polypeptide (gp91phox), intercellular adhesion molecule 1 (ICAM-1), transforming growth factor beta 1 (TGF-β1), connective tissue growth factor (CTGF), endothelin-1 (ET-1), cytochrome B-245, alpha polypeptide (p22phox), endothelin receptor type B (ETB/EDNRB), brain natriuretic peptide (BNP), endothelin receptor type A (ETA/EDNRA), matrix metallopeptidase 13 (MMP13), type I collagen (Col1a1), matrix metallopeptidase 2 (MMP2), TIMP metallopeptidase inhibitor 1 (TIMP1), Type III collagen (Col3a1), interleukin 1 beta (IL-1β), beta myocin heavy chain (β-MHC), endothelin converting enzyme 1 (ECE1) matrix metallopeptidase 14 (MMP14), angiotensinogen (AGT), angiotensin II receptor Type 1 (AT1R), cytochrome C oxidase I (COX1), fms-like tyrosine kinase 1 (FLT1), TIMP metallopeptidase inhibitor 2 (TIMP2), phospholamban (PLN), vascular cell adhesion molecule 1 (VCAM1), extracellular matrix (ECM).
Abnormal thalamocortical pathfinding and terminal arbors lead to enlarged barrels in neonatal GAP‐43 heterozygous mice

GAP‐43 has been implicated in axonal pathfinding and sprouting, synaptic plasticity, and neurotransmitter release. However, its effect on cortical development in vivo is poorly understood. We have previously shown that GAP‐43 knockout (−/−) mice fail to develop whisker‐related barrels or an ordered whisker map in the cortex. Here we used cytochrome oxidase (CO) histochemistry to demonstrate that GAP‐43 heterozygous (+/−) mice develop larger than normal barrels at postnatal day 7 (P7), despite normal body and brain weight. Using serotonin transporter (5HT‐T) histochemistry to label thalamocortical afferents (TCAs), we found no obvious abnormalities in other somatosensory areas or primary visual cortex of GAP‐43 (+/−) mice. However, TCA projections to (+/−) primary auditory cortex were not as clearly defined. To clarify the mechanism underlying the large‐barrel phenotype, we used lipophilic (DiI) axon labeling. We found evidence for multiple pathfinding abnormalities among GAP‐43 (+/−) TCAs. These axons show increased fasciculation within the internal capsule, as well as abnormal turning and branching in the subcortical white matter. These pathfinding errors most likely reflect failures of signal recognition and/or transduction by ingrowing TCAs. In addition, many DiI‐labeled (+/−) TCAs exhibit widespread, sparsely branched terminal arbors in layer IV, reflecting the large‐barrel phenotype. They also resemble those found in rat barrel cortex deprived of whisker inputs from birth, suggesting a failure of activity‐dependent synaptogenesis and/or synaptic stabilization in (+/−) cortex. Our findings suggest that reduced GAP‐43 expression can alter the fine‐tuning of a cortical map through a combination of pathfinding and synaptic plasticity mechanisms. J. Comp. Neurol. 462:252–264, 2003. © 2003 Wiley‐Liss, Inc.