Miracle-dz/UniFAR-FTUs huggingface dataset:
A Home-Based Exercise Program Improves Heart Rate Variability and Functional Capacity Among Postmenopausal Women With Coronary Artery Disease

Aims: To determine whether a home-based exercise program is able to increase functional capacity (FC) and reduce heart rate variability (HRV) in postmenopausal women with coronary heart disease. Background: Regular exercise training has been shown to improve both FC and HRV. However, those studies were conducted within institutional training programs, and few have included women. Methods: Thirty-two postmenopausal women were randomly assigned to either an experimental or control group with 16 participants in each group. Those in the experimental group underwent home-based exercise training, 3 times a week for 8 weeks. On the first and final week, each participant's HRV was measured, and their FC was evaluated using a 6-minute walking test. Findings: After 8 weeks, the FC of those who had undergone the home-based exercise program showed a significant improvement compared with subjects in the control group (P = .001). The total power (ms2), high-frequency (ms2), and low-frequency (ms2) indexes of HRV were also significantly improved over control values. Conclusion: In postmenopausal women with coronary heart disease, a home-based exercise program appears able to improve FC and HRV.
Model predictive control based home energy management system in smart grid

Involving end-users in Demand Side Management (DSM) programs with home energy management systems (HEMS) is an important requirement in realizing the smart grid. In smart grids, advanced communication technologies provide an opportunity to communicate with customers expeditiously. Optimizing the demand side consumption yields economical benefits to both the utility and customer. The HEMS helps the customers to optimize their household appliances' operation. This paper presents the application of model predictive control (MPC) on the HEMS model in order to arrive at the optimal operational decisions when the inputs are subject to variations. Reduction in the total customer's energy cost is achieved. Additionally, the results show increase in customers' revenue from selling the generated and stored energy to the utility.
Racionalismo e empirismo: o papel da imaginação no processo de conceptualização

Este artigo tem o objetivo de problematizar, do ponto de vista filosofico, o papel da imaginacao na formacao de conceitos abstratos nas linguas. Partindo da proposta experiencialista de Lakoff e Johnson ([1980]2002), propoe-se, num primeiro momento, verificar como os filosofos de orientacao racionalista e empirista enxergam o lugar do corpo-materia, da razao e da imaginacao na possibilidade de conhecimento e nomeacao das coisas do mundo. Num segundo momento, tomando por base teorica principal o livro The body in the mind: the bodily bases of meaning, imagination, and reason, de Mark Johnson (1987), a nocao de imaginacao em Kant e abordada com o objetivo de encontrar em tal nocao a explicacao filosofica para a genese dos conceitos metaforicos abstratos.
Characterization of the promoter region of the human PARG gene and its response to PU.1 during differentiation of HL‐60 cells

The metabolism of poly(ADP‐ribose) plays important roles in the nuclear function of mammalian cells. Previously, we analyzed expression of the poly(ADP‐ribose) glycohydrolase (PARG) gene during HL‐60 cell differentiation and found that expression was greatly reduced by 4 h after 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA) treatment and returned to the initial level within 20 h. In the present study, a 2.1‐kb fragment of the 5′‐flanking (promoter) region of the human PARG gene was isolated from the HL‐60 genome by polymerase chain reaction and ligated into a luciferase‐expression vector, pGL3, to generate the pPARG‐Luc#2 reporter plasmid. Deletion analysis revealed that a 75‐nt sequence is required for basal promoter activity and TPA responsiveness. Mutations in this 75‐nt sequence reduced promoter activity and the TPA response of HL‐60 cells. TFSEARCH analysis revealed that Ets family binding motifs are located in the 75‐nt sequence. Chromatin immunoprecipitation assay, electrophoretic mobility shift assay and competition analysis indicated that PU.1 (Spi‐1) binds to the 75‐nt sequence. Moreover, co‐transfection of HL‐60 cells with a PU.1 expression plasmid and pPARG‐Luc indicated that PU.1 down‐regulate the PARG promoter. These results suggest that PARG gene expression is modulated by PU.1 during TPA‐induced differentiation of HL‐60 cells.
Review: Sporadic Parkinson's disease: development and distribution of α‐synuclein pathology

The development of α‐synuclein immunoreactive aggregates in selectively vulnerable neuronal types of the human central, peripheral, and enteric nervous systems is crucial for the pathogenesis of sporadic Parkinson's disease. The presence of these lesions persists into the end phase of the disease, a process that is not subject to remission. The initial induction of α‐synuclein misfolding and subsequent aggregation probably occurs in the olfactory bulb and/or the enteric nervous system. Each of these sites is exposed to potentially hostile environmental factors. Once formed, the aggregates appear to be capable of propagating trans‐synaptically from nerve cell to nerve cell in a virtually self‐promoting pathological process. A regional distribution pattern of aggregated α‐synuclein emerges that entails the involvement of only a few types of susceptible and axonally interconnected projection neurons within the human nervous system. One major route of disease progression may originate in the enteric nervous system and retrogradely reach the dorsal motor nucleus of the vagal nerve in the lower brainstem. From there, the disease process proceeds chiefly in a caudo‐rostral direction through visceromotor and somatomotor brainstem centres to the midbrain, forebrain, and cerebral cortex. Spinal cord centres may become involved by means of descending projections from involved lower brainstem nuclei as well as by sympathetic projections connecting the enteric nervous system with postganglionic peripheral ganglia and preganglionic nuclei of the spinal cord. The development of experimental cellular and animal models is helping to explain the mechanisms of how abnormal α‐synuclein can undergo aggregation and how transmission along axonal connectivities can occur, thereby encouraging the initiation of potential disease‐modifying therapeutic strategies for sporadic Parkinson's disease.
Knockdown and Mortality Comparisons Among Spinosad-, Imidacloprid-, and Methomyl-Containing Baits Against Susceptible Musca domestica (Diptera: Muscidae) Under Laboratory Conditions

Abstract The activity of spinosad, imidacloprid, and methomyl baits and technical actives were assessed against susceptible house flies, Musca domestica L. (Diptera: Muscidae). In a feeding assay, imidacloprid affected flies more rapidly than methomyl or spinosad, but spinosad was 2.7 times more potent than methomyl and 8 times more potent than imidacloprid. The profile of technical actives correlated with their respective fly bait formulations in laboratory assays. Although having the most rapid onset of activity in laboratory tests, up to 50% of flies remained alive after exposure to imidacloprid bait. In contrast, <5% of flies survived 24-h exposure to spinosad or methomyl baits. High temperature reduced the knockdown activity of imidacloprid bait and slowed the speed of kill for spinosad and methomyl baits over a 24-h exposure period. Spinosad and methomyl baits were also superior to imidacloprid when applied to the floors of environmentally controlled rooms at label recommended rates, providing good fly control for up to 21 d. The fact that a significant percentage of flies exposed to imidacloprid were rapidly knocked down but subsequently remained alive in all of the assays suggested that flies were recovering from initial exposure to this compound. Given its favorable safety profile, a high degree of initial and residual activity comparable with methomyl and lack of cross-resistance to other chemistries, spinosad bait may be a valuable component of house fly control programs to help control or delay the emergence of resistant populations.
Hypoxia-reoxygenation affects whole-genome expression in the newborn eye.

PURPOSE Resuscitation of newborns is one of the most frequent procedures in neonatal medicine. The use of supplementary oxygen during resuscitation of the asphyxiated newborn has been shown to be detrimental to vulnerable tissues. We wanted to assess transcriptional changes in ocular tissue after the acute use of oxygen in the delivery room in a hypoxia-reoxygenation model of the newborn mouse. METHODS C57BL/6 mice (n = 57), postnatal day 7, were randomized to receive either 120 minutes of hypoxia, at 8% O2, followed by 30 minutes of reoxygenation with 21, 40, 60, or 100% O2 or to normoxia followed by 30 minutes of 21% or 100% O2. Whole ocular homogenates were analyzed by Affymetrix 750k expression array, and RT-PCR was performed for validation. Bayesian analysis of variance for microarray data (BAMarray) was used to identify single significant genes, and Gene Set Enrichment Analysis (GSEA) was applied to reveal significant pathway systems. RESULTS In total, ∼ 92% of the gene expression changes were altered in response to reoxygenation with 60% or 100% O2 compared to expression at the lower percentages of 21% and 40%. After 100% O2 treatment, genes involved in inflammation (Ccl12), angiogenesis (Igfr1, Stat3), and metabolism (Hk2) were upregulated. Pathway analyses after hypoxia-reoxygenation revealed significant alterations of six pathways which included apoptosis, TGF-beta signaling, oxidative phosphorylation, voltage-gated calcium channel complex, mitochondrion, and regulation of RAS protein signal transduction. CONCLUSIONS Hypoxia-reoxygenation can induce immediate transcriptional responses in ocular tissue involving inflammation, angiogenesis, energy failure, and Ras signaling.
Bringing Quantitative Risk Assessment Closer to the Patient and Surgeon: A Novel Approach to Improve Outcomes

Two recently published studies raise serious questions about the effectiveness of the current use of risk-adjusted outcomes comparisons between hospitals in reducing perioperative mortality, morbidity, and costs. In this Perspectives article, we provide historical background, discuss the limitations, and offer a new paradigm for the application of quantitative risk assessment to the care of the surgical patient.
Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer.

AIM The aim of the present study was to investigate expression patterns of transcription factor NF-κB (p50 and p65), ER, PR, Her2/neu, Ki-67 and p53 in tumor tissue of patients with breast cancer (BC) and analyze correlation between these markers. PATIENTS AND METHODS 62 BC patients previously not treated with chemo- or radiotherapy were included in the study. All tumors belong to invasive ductal carcinoma of different grade. Expression of molecular markers was determined by immunohistochemical analysis on paraffin-embedded tissue sections. RESULTS The correlation between tumor grade and expression of ER, PR, Ki-67 and p53 was defined. NF-κB expression was found to be changed dependent on expression of ER, PR and p53 and also on molecular subtype (luminal, Her2-positive, hybrid, basal-like). The highest levels of NF-κB, Ki-67 and p53 were found in Her2/neu+ and basal-like tumor subtypes. CONCLUSION The increase of nuclear expression of NF-κB correlates with a decrease of expression of steroid hormone receptors (ER and PR), increase of p53 accumulation, and is associated with Her2-positive and basal-like tumor types.
Análise do comportamento de ferramentas de corte com diferentes revestimentos e seu efeito sobre a geração de calor no osso

Com o desenvolvimento de novas tecnologias nas areas da bioengenharia, a ampliacao dos conhecimentos voltados para novos materiais e novos processos tem sido bastante necessaria. Para qualquer aplicacao de determinado biomaterial, seja ele implantado ou tenha simplesmente servido como ferramenta para algum caso clinico, este deve ser cuidadosamente avaliado quanto as suas propriedades quimicas, mecânicas e caracteristicas especificas para cada aplicacao. Para a utilizacao em instrumentais cirurgicos cortantes como as brocas, os acos inoxidaveis vem sendo cada vez mais estudados e aprimorados para que permitam compatibilidade adequada com o corpo humano. Na implantodontia, o processo de osseointegracao depende de diversos fatores que envolvem caracteristicas mecânicas e biologicas relacionadas diretamente aos procedimentos realizados durante a preparacao da cavidade ossea que recebera o implante dentario. Dentre esses fatores pode ser citada a densidade ossea, a rotacao da broca durante a perfuracao, a estabilidade primaria do implante ja instalado, o calor gerado durante a osteotomia, entre outros. O calor gerado durante a osteotomia deve ser adequadamente controlado para que nao ocorram temperaturas superiores a 47C [13], que podem comprometer todo o processo de osseointegracao. A analise da geracao de calor internamente no osso e o comportamento de brocas utilizadas na implantodontia sao, portanto, fatores de grande importância para que se identifiquem pontos relacionados ao sucesso da osseointegracao na instalacao de implantes dentarios. Realizaram-se analises comparativas entre tres diferentes grupos de brocas como segue: I brocas sem revestimento; II brocas com revestimento TiN e III - brocas com revestimento WC/C. Avaliaram-se os indices de desgaste em massa, o aumento da rugosidade e as caracteristicas de afiacao, sendo que todas as avaliacoes foram realizadas antes de qualquer solicitacao mecânica e tambem, ao final de 20 perfuracoes executadas por cada broca simulando osteotomias cirurgicas. Como propriedades mecânicas, foram avaliadas as espessuras dos revestimentos aplicados em dois grupos de brocas, analisadas as composicoes quimicas dos filmes e do substrato e tambem, caracterizacao microestrutural do substrato das amostras. %%%%With the development of new technologies in the areas of bioengineering, the magnifying of the knowledge directed toward new materials and new processes have been sufficiently necessary. For any determined application of biomaterial, either implanted it or simply served as tool for some clinical case, it must be carefully evaluated with chemical and mechanical properties and specific characteristic for each application. To be used in cutting surgical instruments like drills, the stainless steel is been studied and improved to allow the adjustment and compatibility with the human body. In the implantology, the osseointegration process depends on factors that are involved with biological and mechanical characteristics. They are related directly to the procedures carried through…
Mutations in yeast proliferating cell nuclear antigen define distinct sites for interaction with DNA polymerase delta and DNA polymerase epsilon

The importance of the interdomain connector loop and of the carboxy-terminal domain of Saccharomyces cerevisiae proliferating cell nuclear antigen (PCNA) for functional interaction with DNA polymerases delta (Poldelta) and epsilon (Pol epsilon) was investigated by site-directed mutagenesis. Two alleles, pol30-79 (IL126,128AA) in the interdomain connector loop and pol30-90 (PK252,253AA) near the carboxy terminus, caused growth defects and elevated sensitivity to DNA-damaging agents. These two mutants also had elevated rates of spontaneous mutations. The mutator phenotype of pol30-90 was due to partially defective mismatch repair in the mutant. In vitro, the mutant PCNAs showed defects in DNA synthesis. Interestingly, the pol30-79 mutant PCNA (pcna-79) was most defective in replication with Poldelta, whereas pcna-90 was defective in replication with Pol epsilon. Protein-protein interaction studies showed that pcna-79 and pcna-90 failed to interact with Pol delta and Pol epsilon, respectively. In addition, pcna-90 was defective in interaction with the FEN-1 endo-exonuclease (RTH1 product). A loss of interaction between pcna-79 and the smallest subunit of Poldelta, the POL32 gene product, implicates this interaction in the observed defect with the polymerase. Neither PCNA mutant showed a defect in the interaction with replication factor C or in loading by this complex. Processivity of DNA synthesis by the mutant holoenzyme containing pcna-79 was unaffected on poly(dA) x oligo(dT) but was dramatically reduced on a natural template with secondary structure. A stem-loop structure with a 20-bp stem formed a virtually complete block for the holoenzyme containing pcna-79 but posed only a minor pause site for wild-type holoenzyme, indicating a function of the POL32 gene product in allowing replication past structural blocks.
Sophistication about Symmetries

Suppose that one thinks that certain symmetries of a theory reveal ‘surplus structure’. What would a formalism without that surplus structure look like? The conventional answer is that it would be a reduced theory: a theory that traffics only in structures invariant under the relevant symmetry. In this article, I argue that there is a neglected alternative: one can work with a sophisticated version of the theory, in which the symmetries act as isomorphisms. 1. Introduction2. Symmetry3. Reduction4. Sophistication5. Equivalence6. Conclusion Appendix Introduction Symmetry Reduction Sophistication Equivalence Conclusion Appendix
Stroke and Potentially Preventable Dementias Proclamation: Updated World Stroke Day Proclamation.

### The growing epidemic Stroke1 and some dementias may be preventable2 but are rising globally. ### Join forces to prevent stroke and potentially preventable dementias The same few risk factors account for the leading health problems of the world, but research about the common threat occurs in isolation from other major chronic diseases. The common risk factors, tobacco use, alcohol misuse, physical inactivity, and diets high in salt, fats, and sugar, contribute to stroke, heart disease, diabetes mellitus, chronic lung disease, and cancer6 and pose a risk of dementia. Therefore, we need to:
Observation des situations didactiques et pratique réflexive en formation initiale

L'article presente et discute un dispositif de formation initiale developpe a l'IUFM de Toulouse en direction des professeurs stagiaires d'education physique et sportive (EPS). Cette formation a pour objectif d'initier une pratique reflexive a partir de l'observation de l'activite didactique d'un enseignant d'experience. La particularite du dispositif est de transposer a des fins de formation une methode d'observation des interactions didactiques utilisee lors d'une recherche descriptive. L'interet d'une formation reflexive dans le domaine didactique est brievement discute en introduction. Trois points sont ensuite successivement abordes : 1. la presentation des recherches a l'origine de la formation ; 2. la description du dispositif de formation ; 3. la discussion de sa pertinence dans une optique de professionnalisation. Le propos est de situer les enjeux de la formation didactique vis-a-vis de l'experience professionnelle, sa reflexivite et son rapport aux discours et recherches dont elle est l'objet.
Increase of rat alcohol drinking behavior depends on the age of drinking onset.

BACKGROUND Although alcohol drinking onset in younger people is associated with an increased risk of alcohol-related injuries, other factors, such as habituation and susceptibility to alcohol, in the process of aging have not been adequately examined in animal models. In the present study, we determined whether age of drinking onset affected alcohol drinking behavior and led to alcohol tolerance in experimental animals, and extrapolated some of the findings to human alcohol drinking patterns. METHODS In the first experiment, 18 rats that were naive to alcohol were tested at the age of 1, 4, and 10 months with 4 hr of access to 10% (v/v) alcohol. After the time access tests, these animals (1, 4, and 10 months of age) were housed individually and given free access to 10% alcohol solution and tap water. At 3 and 6 months later, all rats that had experienced alcohol drinking were studied for the voluntary consumption of the alcohol solution, alcohol preference, under the two-bottle method in a second experiment. RESULTS In the 4-hr alcohol-access test, alcohol intake (g/kg/hr) was significantly increased at 0.5 and 1 hr in 1- and 4-month-old naive rats compared with 10-month-old naive rats. The daily alcohol intake (g/kg/day) of rats with drinking onset at 1 month of age was significantly increased at 3 and 6 months after the voluntary alcohol consumption. The daily alcohol intake in the rats with drinking onset at 4 months of age was significantly increased at 6 months only. However, the daily alcohol intake did not change in the rats with drinking onset at 10 months of age through the alcohol preference test. CONCLUSIONS Alcohol drinking behavior in experimental animals depends on the age of alcohol drinking onset.
Pattern recognition on a quantum computer

By means of a simple example it is demonstrated that the task of ﬁnding and identifying certain patterns in an otherwise (macroscopically) unstructured picture (data set) can be accomplished eﬃciently by a quantum computer. Employing the powerful tool of the quantum Fourier transform the proposed quantum algorithm exhibits an exponential speed-up in comparison with its classical counterpart. The digital representation also results in a signiﬁcantly higher accuracy than the method of optical ﬁltering.
Socio-economic determinants of drugged driving--a register-based study.

AIMS To examine the associations between socio-economic characteristics and driving under the influence of drugs (DUID), and to elaborate determinants of drugged driving. DESIGN A register-based case-control study. SETTING Finland. PARTICIPANTS Cases (n = 5859) apprehended by the police and suspected of DUID during 1993-2006 and controls (n = 74 809) drawn from the general Finnish population. MEASUREMENTS The effects of parents' and own education, urbanization of municipality, socio-economic position (SEP), main activity, income, marital status and living arrangements on DUID were estimated using logistic regression analysis. The analyses were conducted separately for men and women, age groups of under 45 years and aged 45 or over, and for substance groups of benzodiazepines only, benzodiazepines with alcohol, amphetamines and cannabinoids. FINDINGS Low education, unemployment, disability pension, being divorced and living alone were the strongest individual predictors of DUID in all substance groups. Illicit drug users were more disadvantaged compared to those in the benzodiazepines groups. Contrary to other substance and age groups, higher educational level and higher SEP were associated with DUID among benzodiazepine users aged 45 or over. CONCLUSIONS A disadvantaged social background is a significant predictor of driving while under the influence of drugs for all substance use groups in Finland. The gradient is greater for amphetamines and cannabinoids than benzodiazepines.
Software para auxílio ao diagnóstico de autismo

A deteccao precoce do Autismo em criancas e crucial para o inicio do tratamento e, consequentemente, para a melhora da qualidade de vida destes individuos. Entretanto, estudos apontam que, em geral, apenas a partir dos tres anos de idade e possivel ter um diagnostico preciso. Aliado a isto, ha uma quantidade insuficiente de profissionais capacitados para detectar este tipo de transtorno. Assim, baseado em trabalhos recentes, este trabalho tem o objetivo de desenvolver uma ferramenta computacional nao invasiva para o auxilio ao diagnostico do Autismo, a partir de videos de sessoes diagnosticas e atraves de tecnicas de Visao Computacional. Com isto, espera-se que este software venha a ser utilizado no futuro por em entidades competentes no Brasil, para um diagnostico precoce nas criancas.