Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel L5-S1 interbody fusion technique for root anomalies or abnormal root configurations of L5-S1 foramens

Purpose: We show in this study that if a root anomaly does not permit access to the disc space in the usual way, the technique we define here can be used. If the patient has a root anomaly or an abnormal root configuration at this level, inevitably, an anterior approach is preferred. Materials and Methods: The patient's previous skin incision was used; the L5-S1 space was reached laterally without entering the midline. The dura in the midline and the L5 and S1 roots on both sides were exposed. They were reached through the adjacent points of both S1 pedicles by going around the upper edge of the sacrum, allowing the disc space to be evacuated. An autologous bone graft was placed on both sides of the space. T10-S1 pedicle screws were placed. An L1 pedicle osteotomy was performed and joined using two rods. Results: The patient's back and leg pain disappeared after the surgery. The plain X-rays showed that the sagittal balance was restored. In this case, it is impossible to see the disc space because the nerve root blocks its view. Conclusions: The classic approach in such cases is to perform a fusion by either a transperitoneal or retroperitoneal approach or by performing a posterior intertransverse fusion. However, it is very challenging to execute an anterior L5-S1 fusion on a patient with pelvic retroversion. When the spinopelvic junction is included in the fusion, one common problem observed is pseudarthrosis. The surgical technique defined in this article makes it possible to drill the bone tissue through the disc space and the upper surface of the sacrum, accessing the pedicle bone. Then, a discectomy is performed at the disc space, a bone graft is placed, and a posterior lumbar interbody fusion is performed.
Comparative study on the donor site aesthetic outcome between epidermal graft and split‐thickness skin graft

Donor site aesthetic outcomes of epidermal graft (EG) vs split‐thickness skin graft (SSG) have yet to be objectively compared. Here, we evaluate donor site healing using a validated scar assessment tool and digital colorimetric technique, which compares colour in a consistent and objective manner. Ten patients (SSG (n = 5) and EG (n = 5)) were included. Donor site scarring was evaluated using the Vancouver Scar Scale (VSS) at Week 6 and Month 3. Colorimetric measurement was performed at Weeks 3 and 6 and Month 3. The mean donor site healing time for EG was significantly shorter (EG: 4.6 days (95% c.i. 3.8‐5.3), SSG: 16.8 days (95% c.i. 13.3‐20.1) (P = 0.003)). The VSS scores of the EG donor site were lower at Week 6 and Month 3(P < 0.001). The colour match between the donor site and surrounding skin for EG was better compared with SSG at all time points and was almost identical to their surrounding healthy skin at Month 3. This study is the first to objectively measure the clinical appearance of the EG donor site against SSG. EG donor site has faster healing with excellent scarring and good colour match with its surrounding normal skin at all time points compared with SSG.
Pharmacological modulation of mitochondrial ion channels

The field of mitochondrial ion channels has undergone a rapid development during the last three decades, due to the molecular identification of some of the channels residing in the outer and inner membranes. Relevant information about the function of these channels in physiological and pathological settings was gained thanks to genetic models for a few, mitochondria‐specific channels. However, many ion channels have multiple localizations within the cell, hampering a clear‐cut determination of their function by pharmacological means. The present review summarizes our current knowledge about the ins and outs of mitochondrial ion channels, with special focus on the channels that have received much attention in recent years, namely, the voltage‐dependent anion channels, the permeability transition pore (also called mitochondrial megachannel), the mitochondrial calcium uniporter and some of the inner membrane‐located potassium channels. In addition, possible strategies to overcome the difficulties of specifically targeting mitochondrial channels versus their counterparts active in other membranes are discussed, as well as the possibilities of modulating channel function by small peptides that compete for binding with protein interacting partners. Altogether, these promising tools along with large‐scale chemical screenings set up to identify new, specific channel modulators will hopefully allow us to pinpoint the actual function of most mitochondrial ion channels in the near future and to pharmacologically affect important pathologies in which they are involved, such as neurodegeneration, ischaemic damage and cancer.
Repeated-sprints exercise in daylight fasting: carbohydrate mouth rinsing does not affect sprint and reaction time performance

To determine the effect of carbohydrate mouth rinsing (CHO-MR) on physical and cognitive performance during repeated-sprints (RS) after 3 days of intermittent fasting (abstaining from food and fluid 14 h per day). In a randomized and counter-balanced manner 15 active healthy males in a fasted state performed a RS-protocol [RSP; 2 sets (SET1 and SET2) of 5×5 s maximal sprints, with each sprint interspersed with 25 s rest and 3 min of recovery between SET1 and SET2] on an instrumented non-motorized treadmill with embedded force sensors under three conditions: i) Control (CON; no-MR), ii) Placebo-MR (PLA-MR; 0% maltodextrin) and iii) CHO-MR (10% maltodextrin). Participants rinsed their mouth with either 10 mL of PLA-MR or CHO-MR solution for 5 s before each sprint. Sprint kinetics were measured for each sprint and reaction time (RTI) tasks (simple and complex) were assessed pre-, during- and post-RSP. There was no statistical main effect of CHO-MR on mean power, mean speed, and vertical stiffness during the sprints between the PLA-MR and CON condition. Additionally, no statistical main effect for CHO-MR on accuracy, movement time and reaction time during the RTI tasks was seen. CHO-MR did not affect physical (RSP) or cognitive (RTI) performance in participants who had observed 3 days of intermittent fasting (abstaining from food and fluid 14 h per day).
Pirin: a potential novel therapeutic target for castration‐resistant prostate cancer regulated by miR‐455‐5p

Androgen deprivation therapy is frequently used to treat prostate cancer (PCa), but resistance can occur, a condition known as castration‐resistant prostate cancer (CRPC). Thus, novel approaches for identification of CRPC are important for designing effective PCa treatments. Analysis of microRNA (miRNA) expression signatures by RNA sequencing showed that both passenger and guide strands of the miR‐455‐duplex (miR‐455‐5p and miR‐455‐3p, respectively) acted as antitumor miRNAs in PCa cells. The involvement of miRNA passenger strands in cancer pathogenesis is a novel concept for miRNA functionality. Based on a large patient cohort in The Cancer Genome Atlas, expression of eight miR‐455‐5p/‐3p target genes (PIR: P = 0.0137, LRP8: P = 0.0495, IGFBP3: P = 0.0172, DMBX1: P = 0.0175, CCDC64: P = 0.0446, TUBB1: P = 0.0149, KIF21B: P = 0.0336, and NFAM1: P = 0.0013) was significantly associated with poor prognosis of PCa patients. Here, we focused on PIR (pirin), a highly conserved member of the cupin superfamily. PIR expression was directly regulated by miR‐455‐5p, and PIR overexpression was detected in hormone‐sensitive prostate cancer (HSPC) surgical specimens and CRPC autopsy specimens. Loss‐of‐function assays using siRNA or an inhibitor (bisamide) showed that downregulation of PIR expression blocked cancer cell migration and invasion. Moreover, the miR‐455‐5p/PIR axis contributed to cancer cell aggressiveness. These results suggest that PIR might be a promising diagnostic marker for HSPC and CRPC. Furthermore, CRPC treatment strategies targeting PIR may be possible in the future. Identification of antitumor miRNAs, including miRNA passenger strands, may contribute to the development of new diagnostic markers and therapeutic strategies for CRPC.
Elite football teams that do not have a winter break lose on average 303 player-days more per season to injuries than those teams that do: a comparison among 35 professional European teams

Objective To compare injury rates among professional men’s football teams that have a winter break in their league season schedule with corresponding rates in teams that do not. Methods 56 football teams from 15 European countries were prospectively followed for seven seasons (2010/2011–2016/2017)—a total of 155 team-seasons. Individual training, match exposure and time-loss injuries were registered. Four different injury rates were analysed over four periods within the season, and linear regression was performed on team-level data to analyse the effect of winter break on each of the injury rates. Crude analyses and analyses adjusted for climatic region were performed. Results 9660 injuries were reported during 1 447 011 exposure hours. English teams had no winter break scheduled in the season calendar: the other European teams had a mean winter break scheduled for 10.0 days. Teams without a winter break lost on average 303 days more per season due to injuries than teams with a winter break during the whole season (p<0.001). The results were similar across the three periods August–December (p=0.013), January–March (p<0.001) and April–May (p=0.050). Teams without a winter break also had a higher incidence of severe injuries than teams with a winter break during the whole season (2.1 severe injuries more per season for teams without a winter break, p=0.002), as well as during the period January–March (p=0.003). A winter break was not associated with higher team training attendance or team match availability. Climatic region was also associated with injury rates. Conclusions The absence of a scheduled winter break was associated with a higher injury burden, both before and during the two periods following the time that many European teams take a winter break. Teams without a winter break (English clubs) had a higher incidence of severe injuries following the time of the year that other teams (other European clubs) had their scheduled break.
Contagious sets in a degree‐proportional bootstrap percolation process

We study the following bootstrap percolation process: given a connected graph G, a constant ρ ∈ [0,1] and an initial set A⊆V(G) of infected vertices, at each step a vertex v becomes infected if at least a ρ‐proportion of its neighbors are already infected (once infected, a vertex remains infected forever). Our focus is on the size hρ(G) of a smallest initial set which is contagious, meaning that this process results in the infection of every vertex of G. Our main result states that every connected graph G on n vertices has hρ(G) < 2ρn or hρ(G) = 1 (note that allowing the latter possibility is necessary because of the case ρ≤12n , as every contagious set has size at least one). This is the best‐possible bound of this form, and improves on previous results of Chang and Lyuu and of Gentner and Rautenbach. We also provide a stronger bound for graphs of girth at least five and sufficiently small ρ, which is asymptotically best‐possible.
Passing experiences on to future generations: endocrine disruptors and transgenerational inheritance of epimutations in brain and sperm

ABSTRACT All animals have body burdens of polychlorinated biphenyls (PCBs) despite their ban decades ago. These and modern endocrine-disrupting chemicals (EDCs) such as the fungicide vinclozolin (VIN) perturb hormone signaling and lead to dysfunctions following prenatal exposures. Beyond direct exposures, transgenerational disease phenotypes can persist for multiple generations without subsequent exposure. The mechanisms of action of these EDCs differ: VIN is anti-androgenic while the PCB mixture Aroclor 1221 (A1221) is weakly estrogenic. Based on limited evidence for the inheritance of epimutations in germline, we measured DNA methylation in brain and sperm of rats. Pregnant dams were exposed from day 8–18 of gestation to low dosages of VIN, A1221, or the vehicle. To produce paternal lineages, exposed F1 males were bred with untreated females, creating the F2 and subsequently F3 generations. In adult F1 and F3 males, mature sperm was collected, and brain nuclei involved in anxiety and social behaviors (CA3 of the hippocampus; central amygdala) were selected for assays of epimutations in CpG islands using reduced representation bisulfite sequencing. In F1 sperm, VIN and PCBs induced differential methylation in 215 and 284 CpG islands, respectively, compared to vehicle. The majority of effects were associated with hypermethylation. Fewer epimutations were detected in the brain. A subset of differentially methylated regions were retained from the F1 to the F3 generation, suggesting a common mechanism of EDC and germline epigenome interaction. Thus, EDCs can cause heritable epimutations in the sperm that may embody the future phenotype of brain-behavior disorders caused by direct or transgenerational exposures.
Automatic Musculoskeletal and Neurological Disorder Diagnosis With Relative Joint Displacement From Human Gait

Musculoskeletal and neurological disorders are common devastating companions of ageing, leading to a reduction in quality of life and increased mortality. Gait analysis is a popular method for diagnosing these disorders. However, manually analyzing the motion data is a labor-intensive task, and the quality of the results depends on the experience of the doctors. In this paper, we propose an automatic framework for classifying musculoskeletal and neurological disorders among older people based on 3D motion data. We also propose two new features to capture the relationship between joints across frames, known as 3D Relative Joint Displacement (3DRJDP) and 6D Symmetric Relative Joint Displacement (6DSymRJDP), such that the relative movement between joints can be analyzed. To optimize the classification performance, we adapt feature selection methods to choose an optimal feature set from the raw feature input. Experimental results show that we achieve a classification accuracy of 84.29% using the proposed relative joint features, outperforming existing features that focus on the movement of individual joints. Considering the limited open motion database for gait analysis focusing on such disorders, we construct a comprehensive, openly accessible 3D full-body motion database from 45 subjects.
Player experiences in a massively multiplayer online game: A diary study of performance, motivation, and social interaction

Video game researchers have struggled to capture players’ personal experiences in natural gaming contexts. We used longitudinal diary methods to examine the everyday experiences of new and experienced players within a massively multiplayer online game, Team Fortress 2. Participants (N = 38) completed diaries about gameplay and negative social interactions such as trash-talking and harassment. Themes included frustrating play and performance as motivator, as well as six themes regarding social interaction: skill disparagement, fairweather friends, toxic masculinity, vicious cycles, “kicking” players, and reporting differences. Some findings supported existing research; others challenge previous research using other methods. We discuss the advantages and disadvantages of using diary methods in video game research.
Local resilience of an almost spanning k‐cycle in random graphs

The famous Pósa‐Seymour conjecture, confirmed in 1998 by Komlós, Sárközy, and Szemerédi, states that for any k ≥ 2, every graph on n vertices with minimum degree kn/(k + 1) contains the kth power of a Hamilton cycle. We extend this result to a sparse random setting. We show that for every k ≥ 2 there exists C > 0 such that if p≥C(logn/n)1/k then w.h. p. every subgraph of a random graph Gn,p with minimum degree at least (k/(k + 1) + o(1))np, contains the kth power of a cycle on at least (1 − o(1))n vertices, improving upon the recent results of Noever and Steger for k = 2, as well as Allen, Böttcher, Ehrenmüller, and Taraz for k ≥ 3. Our result is almost best possible in three ways: for p ≪ n−1/k the random graph Gn,p w.h. p. does not contain the kth power of any long cycle; there exist subgraphs of Gn,p with minimum degree (k/(k + 1) + o(1))np and Ω(p−2) vertices not belonging to triangles; there exist subgraphs of Gn,p with minimum degree (k/(k + 1) − o(1))np which do not contain the kth power of a cycle on (1 − o(1))n vertices.
Beyond viral suppression: the quality of life of people living with HIV in Sweden

ABSTRACT Sweden has one of the best HIV treatment outcomes in the world and an estimated 95% of all diagnosed people living with HIV are virally suppressed, but the quality of life (QoL) is understudied. The aim of this study was to examine the associations between variables within sociodemographic, behavioural, clinical, psychological, sexual life, social support and personal resource component and the QoL of people living with HIV in Sweden. Data were derived from a cross-sectional, nation-wide survey completed by 15% (n = 1096) of all people living with HIV and collected at 15 infectious disease clinics and 2 needle exchange sites during 2014. Ordinal univariate and multivariate logistic regression analyses were used to examine associations between potential contributors and QoL. Respondents reported high QoL: 63% rated their QoL 7 or higher on a scale ranging from 0 to 10. QoL was independent of gender, age, mode of HIV transmission and country of origin. Lower QoL was associated with recent homelessness, hazardous alcohol consumption, comorbidities, treatment side-effects, HIV-related physical symptoms, hopelessness, negative self-image, sexual dissatisfaction, and negative changes in sex life after HIV. The QoL of people living with HIV in Sweden was high overall, but still significantly influenced by HIV.
Probabilistic Random Forest: A Machine Learning Algorithm for Noisy Data Sets

Machine learning (ML) algorithms have become increasingly important in the analysis of astronomical data. However, because most ML algorithms are not designed to take data uncertainties into account, ML-based studies are mostly restricted to data with high signal-to-noise ratios. Astronomical data sets of such high quality are uncommon. In this work, we modify the long-established Random Forest (RF) algorithm to take into account uncertainties in measurements (i.e., features) as well as in assigned classes (i.e., labels). To do so, the Probabilistic Random Forest (PRF) algorithm treats the features and labels as probability distribution functions, rather than deterministic quantities. We perform a variety of experiments where we inject different types of noise into a data set and compare the accuracy of the PRF to that of RF. The PRF outperforms RF in all cases, with a moderate increase in running time. We find an improvement in classification accuracy of up to 10% in the case of noisy features, and up to 30% in the case of noisy labels. The PRF accuracy decreased by less then 5% for a data set with as many as 45% misclassified objects, compared to a clean data set. Apart from improving the prediction accuracy in noisy data sets, the PRF naturally copes with missing values in the data, and outperforms RF when applied to a data set with different noise characteristics in the training and test sets, suggesting that it can be used for transfer learning.
Contribution of Bipolar Cells of Cone ON and OFF Pathways to Electroretinograms Elicited by Ultraviolet and Middle Wavelength Stimuli

ABSTRACT Purpose: To determine the contribution of the ON and OFF cone bipolar cell pathways to the electroretinograms (ERGs) elicited by ultraviolet (UV) and middle wavelength light in mice. Materials and Methods: The experiments were performed on 8- to 10-week-old C57BL/6J mice. The ERGs elicited by single-flash and flickering UV light stimuli were compared to those elicited by green light stimuli under photopic conditions. Pharmacological agents were used to selectively block the ON and OFF pathways contributing to the ERGs. Saline was used as a control. The flicker ERGs elicited by UV light were compared to the ERGs elicited by green light after the injection of the pharmacological agents to determine the contribution of the cone ON and OFF pathways to the ERGs. Results: The photopic single-flash and flicker ERGs were more sensitive to the UV light stimuli than to those elicited by green light stimuli. The flicker ERG responses elicited by both UV and green light stimuli at stimulus frequencies lower than 15-Hz decreased after L-2-amino-4-phosphobutyric acid was injected. The ERGs elicited by UV light at 30-Hz and by green light at frequencies lower than 15-Hz decreased significantly after the intravitreal injection of cis-2, 3-piperidine-dicarboxylic acid. An analysis of the ON and OFF components of the flicker ERGs showed that there might be pharmacological differences between the UV light-sensitive responses and the green light-sensitive responses. Conclusions: These results suggest that the UV light-sensitive cones connect to both the ON and OFF bipolar cells differently than that of the green light-sensitive cones.
Clinical decisions and stigmatizing attitudes towards mental health problems in primary care physicians from Latin American countries

Objective The aim of this paper is to investigate how doctors working in primary health care in Latin American address patients with common mental disorders and to investigate how stigma can affect their clinical decisions. Methods Using a cross-sectional design, we applied an online self-administered questionnaire to a sample of 550 Primary Care Physicians (PCPs) from Bolivia, Brazil, Cuba and Chile. The questionnaire collected information about sociodemographic variables, training and experience with mental health care. Clinicians’ stigmatizing attitudes towards mental health were measured using the Mental Illness Clinicians' Attitudes Scale (MICA v4). The clinical decisions of PCPs were assessed through three clinical vignettes representing typical cases of depression, anxiety and somatization. Results A total of 387 professionals completed the questionnaires (70.3% response rate). The 63.7% of the PCPs felt qualified to diagnose and treat people with common mental disorders. More than 90% of the PCPs from Bolivia, Cuba and Chile agreed to treat the patients presented in the three vignettes. We did not find significant differences between the four countries in the scores of the MICA v4 stigma levels, with a mean = 36.3 and SD = 8.3 for all four countries. Gender (p = .672), age (p = .171), training (p = .673) and years of experience (p = .28) were unrelated to stigma. In the two multivariate regression models, PCPs with high levels of stigma were more likely to refer them to a psychiatrist the patients with depression (OR = 1.03, 95% CI, 0.99 to 1.07 p<0.05) and somatoform symptoms somatoform (OR = 1.03, 95% CI, 1.00 to 1.07, p<0.05) to a psychiatrist. Discussion The majority of PCPs in the four countries were inclined to treat patients with depression, anxiety and somatoform symptoms. PCPs with more levels of stigma were more likely to refer the patients with depression and somatoform symptoms to a psychiatrist. Stigmatizing attitudes towards mental disorders by PCPs might be important barriers for people with mental health problems to receive the treatment they need in primary care.
A Bibliometric Analysis of Glottometrics

Glottometrics, one of the most authoritative journals in quantitative linguistics, has celebrated its 17 th anniversary in 2017. In this paper, we conduct a bibliometric study of this journal. By statistical analysis of the basic data in all the 37 volumes published so far (2001-2017), we explore the publication profile, contributors, research content, and citations based on the self-built library and corpora. Results provide a glimpse of development and research status of quantitative linguistics. Suggestions of further improvements for this journal are also proposed.