Miracle-dz/UniFAR-FTUs huggingface dataset:
Hesperidin, a natural citrus flavanone, alleviates hyperglycaemic state and attenuates embryopathies in pregnant diabetic mice

In this study, we attempted to investigate the effect of hesperidin, a natural antioxidant citrus flavanone, on diabetes-induced embryopathies in mice. Streptozotocin (STZ) was injected intraperitoneally in 60 mg/kg bw/day for 3 consecutive days to induce diabetes in virgin females. 72 h later, mating was applied and hesperidin was orally given to pregnant diabetic mice in 20 ppm from the 1 st to the 18 th day of approximately 19 days-gestational length. Maternal body weight and glycaemia were measured throughout pregnancy. Mice were euthanized on day 18 in order to evaluate the teratological parameters. The results showed a considerable decrease of maternal body weight at the last week of pregnancy in hesperidin-treated diabetic mice. Maternal glycaemia was slowly attenuated by hesperidin with a significantly manifest effect on days 11 and 18. This flavanone enhanced the number of implantations per litter, the overall number of foetuses and the absolute and relative foetal weights while reducing malformations and resorptions rates. The red alizarin-staining procedure for foetal skeleton demonstrated a full protective role of hesperidin since, as in controls, no skeletal defects were found in treated diabetic group. These findings suggest that hesperidin may have a prophylactic effect against diabetic embryopathies in mice.
A Community Partnership Approach to Building and Empowering a Palliative Care Resource Nurse Team

Although mandates issued by the World Health Organization and the International Council of Nurses call for increased healthcare provider knowledge of palliative care, current education does not adequately prepare clinicians to provide comprehensive care to the seriously ill and dying. Despite the rising acuity of hospitalized patients with increasingly complex care needs, the majority of nurses working today have had no formal palliative care education. This is particularly unfortunate, as nurses are in a unique and powerful position to influence the quality of palliative care delivered at the bedside. Our intervention attempts to shrink the "palliative care education gap" by designing, implementing, and evaluating a program of advanced training of a palliative care resource nurse team at a tertiary-care university medical center. Quantitative and qualitative data collected suggest that palliative care resource nurse teams can help improve the frontline delivery of palliative care in the acute care setting and that hospital-based nurses are eager for this information and recognize its relevance to their clinical practice. This article details an experience of palliative care nursing curriculum development, implementation, and evaluation that may be applicable to other institutions who wish to enhance nursing knowledge and delivery of palliative care.
Les actions grises dans la théorie des ressources : une compétence cardinale pour la PME ?

Les actions grises constituent une pratique d’influence qui permet d’attenuer les conditions theoriques et legales de la concurrence. Elles se distinguent du concept de veille strategique en liant information et action et demandent des ressources specifiques. Toutefois, leur maitrise permet-elle de fonder un avantage concurrentiel soutenable ? Nous referant au modele des ressources et competences, nous mettons le concept d’actions grises a l’epreuve des criteres de l’avantage concurrentiel. L’etude de cinq PME, selectionnees pour leur maitrise des actions grises et l’impact decisif engendre, nous amene a conclure que cette competence confere un avantage concurrentiel soutenable. Notre resultat doit cependant etre nuance. En effet, l’analyse du critere de la longevite amene a preconiser le maintien d’un systeme de veille traditionnel comme mode d’observation et de surveillance de l’environnement.
Design und Betrieb von Cross Docks

Die hohen Anforderungen an heutige Wertschopfungsnetzwerke in Bezug auf Flexibilitat und Lieferbereitschaft stellen die Distribution vor die Aufgabe, Guter immer haufiger und in immer kleineren Mengen ausliefern zu mussen. Ein Ansatz, diesen Forderungen auf moglichst wirtschaftliche Art und Weise gerecht zu werden, besteht darin, bestehende Distributionsnetze um sogenannte Cross Docks zu erweitern. In solchen lagerlosen Umschlagzentren konnen dann kleine Warensendungen mit ahnlicher Destination zu vollstandig ausgelasteten Lkw-Transporten konsolidiert werden, um sogenannte "economies in transportation" realisieren zu konnen. Neben den strategischen Uberlegungen fur und wider die Einfuhrung von Cross Docks stehen in diesem Aufsatz insbesondere die Planungsprobleme im Mittelpunkt, die es im Rahmen der Errichtung und der taglichen Prozessablaufe in einem Cross Docking Terminal zu losen gilt.
Homocystinuria, a metabolic disease of late diagnosis in Peru

PALABRAS CLAVE: Enfermedades metabolicas, habito marfanoide, homocistinuria, Peru, diagnostico tardio. SUMMARY Homocystinuria is an autosomal-recessive metabolic disorder whose classical phenotype is caused by a deficiency of cystathionine β-synthase, due to mutations within the CBS gene (Cr21q22.3). Herein we report a 17 year old man with hypopigmented skin and hair, mental retardation, marfanoid habitus, severe myopia, bilateral lens subluxation, psychotic episodes, and left-sided hemiparesis secondary to a lacunar brain infarction. Laboratory tests showed increased levels of homocysteine (>9.9mg/dl) in plasma and high levels of urinary sodium nitroprusside (4+), consistent with the clinical diagnosis of classical homocystinuria. This systemic disorder includes dermal, ophthalmic, cognitive, osteoarticular and psychiatric alterations, all of which could be potentially prevented with early diagnosis and therapy as part of newborn screening, which is still unavailable in Peru.
55 the recognition of paediatric sports related concussion (5–16 year olds), initial management and advice among london based emergency medicine trainees

Objective This study aimed to investigate knowledge of paediatric concussion amongst emergency medicine trainees, testing the hypothesis that emergency medicine trainees lack sufficient knowledge to competently assess, diagnose and manage sports-related paediatric concussion. Design cross-sectional questionnaire survey. Setting Secondary care emergency medicine departments. Participants All emergency medicine trainees in one geographical training region in the UK were invited to participate. Outcome measures occupational grade, years of experience, history of specific concussion training, awareness of head injury guidelines, perceived knowledge and confidence in concussion diagnosis and management. Main results Sixty questionnaires were returned. Across all training grades, the mean correct response score on questions of diagnosis, assessment and management of concussion was 73.4%. Nearly 70% of trainees were not aware of any concussion guidelines, and only 10% had attended a course or received training regarding concussion. There was a negative correlation between awareness of guidelines and perceived confidence (r=−0.50 p<0.001), and knowledge in diagnosis and management of concussion (r=−0.51, p<0.001). The majority (91.7%) of the participants would like further education on concussion management, with an online learning module being the preferred format (71.7%). Conclusions The study revealed insufficient level of knowledge and confidence in the assessment, diagnosis and management of paediatric concussion among emergency medicine trainees. None of the variables studied statistically predicted knowledge score. Additional concussion-specific education would be beneficial to optimise trainees’ knowledge of paediatric concussion. Competing interests None.
Theatre Dictionaries: A View from Inside

The theatre has an elaborate terminology of its own, completely adequate to its manifold necessities, and as precise in its meaning and as accurate in its application as the vocabulary of any of the sciences. To the outsider the technicalities of the stage are likely to be as mysterious as those of any other department of human activity,—as mysterious and as misleading. A star-trap, for example, is not intended for the sole use of a star; on the contrary it is a mechanical device the obvious dangers of which no star would ever be called upon to risk. A baby-spot carries with it no suggestion that a stage infant is about to break out with the measles;. Nor has a raking-piece anything whatever to do with gardening (1919:252).
The Attitudes of the Physical Education Students Towards Internet.

Internet is a part of our life today. It offers educators alternative teaching methods. It provides us to get efficient and fast information, establishing contact with everyone and to have a chance for searching all types of data with its globalization effect. Internet facilities help physical education teachers to search lonely in order to get information in a sTable: and comforTable: way. In addition to this, at educational areas, physical education students get various capacities and properties for their future life. In that sense, technology makes people to have self-differentiated features in order to get wide range of knowledge and about all issues and everyone has same opportunities for gathering this knowledge. The study is that attitudes of students about internet by considering their tendencies emerging with described statements to realize new generation perspectives whose are graduate and post graduate students. At this research study, questionnaire examined the consciousness of students towards internet to the sample of students whose are a hundred fifty nine in Sakarya University.
Term recognition using combined knowledge sources

Electric high-voltage equipment such as a circuit breaker, includes a chamber in which high voltage parts may be positioned and containing electrically insulating compressed-gas capable of condensation to a liquid under increased pressure and/or lowered temperature. A condensate-collecting container is connected to the chamber to receive the condensed liquid. The chamber operates at high pressure and the container at a lower pressure, causing the condensate to vaporize therein to a gas. This gas is pumped, with increased pressure, from the container back into the chamber where the higher pressure is to be maintained. A float valve controls the discharge of condensate from the high pressure chamber into the low pressure container.
Screw-semantic content analysis for repair and evaluation of web accessibility

The Internet has continuously found its way into our everyday lives, both in a professional setting as well as in entertainment. It has become an important resource for our daily activities, from work to recreation. This means that increasingly more people are browsing the WWW. There are many types of users and some of them suffer from impairments, constraining their user experience. This leads to the pursuit of an accessible Web for all types of users. This process is aided with a set of guidelines (e.g. WCAG) established by a organization, W3C. These guidelines aside from being a useful guide for Web developers, they are also used by Web accessibility tools that evaluate Web pages in order to check issues. However most of these tools cannot resort to a page’s semantics and can only make syntactic evaluations. Also, they are not capable to repairing them. Therefore, this two subjects are the main objectives covered in this study: semantic evaluation and repair for web accessibility. For this purpose a tool called Screw is presented, which performs semantic evaluations to verify the relation between Web content (text and images) and their descriptions, applying an algorithm. For the repair mechanism, it generates new descriptions when the originals are considered bad by the tool. To support this development, two studies were carried, one for the algorithm’s optimization and the other one to verify the quality of Screw’s assessments, after the algorithm has been adjusted. For Web accessibility, Screw is integrated in Qualweb, a Web accessibility evaluator, in order to improve its evaluations to a new stage with semantic evaluation. Additionally, a plugin for Google Chrome browser was developed to repair Web pages in real time, according to Qualweb and Screw’s results.
Rôles de l'implication et des émotions dans le traitement et la diffusion d'un message : une approche expérimentale des rumeurs

Les deux experiences presentees ici s’interessent au role de l’implication et des emotions dans le traitement et la diffusion d’un message. La premiere recherche qui manipulait le degre d’implication des sujets (Forte vs Faible Implication) indique qu’une forte implication limite la reduction du message et accroit l’assimilation et l’accentuation dont son contenu fait l’objet. Au niveau comportement, il en decoule des intentions de reaction ainsi qu’une mobilisation effective plus marquees sous forte implication. La seconde experience qui manipulait en outre l’emotion induite (Induction de la colere vs d’aucune emotion specifique) confirme ces resultats et met egalement en evidence des effets plus limites de l’emotion qui se traduisent essentiellement par une limitation de la reduction et une augmentation de l’assimilation, sans repercussion au niveau comportemental. Ces resultats sont discutes sur la base du modele de traitement heuristique vs systematique de l’information, et notamment des motivations epistemique vs defensive qu’il suppose, ainsi que des modeles elabores a propos des effets cognitifs et comportementaux des emotions.
Une invitation au tourisme : l’affiche ferroviaire française (1880-1936)

Partant du postulat que l’image participe a part entiere de la connaissance des faits historiques, nous nous sommes appliques, dans le cadre d’une contribution a l’histoire du marketing touristique, a decrire la creation et la reception de l’affiche ferroviaire francaise de 1880 a 1936. A travers ce cas particulier, il s’agissait d’approfondir l’histoire des facteurs de production de la promotion touristique des stations, des comportements qu’ils conditionnent, des couts qu’ils determinent. C.
BGP／MPLS VPN的实现技术

MPLS VPN技术是未来构建VPN的发展方向,越来越受到客户和运营商的青睐. BGP/MPLS VPN是第三层MPLS VPN技术. 本文在对VRF、RD、RT几个重要概念进行解释之后,对BGP/MPLS VPN的数据转发过程和路由信息分发过程进行了较为详细的叙述. 最后通过分析BGP/MPLS VPN的特点,分析了其市场前景.
Abstract 474: Efficacy and Safety of LCZ696 Compared with Olmesartan in Japanese Patients with Systolic Hypertension

Objective: To evaluate the efficacy and safety of LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor (ARNI) vs olmesartan in Japanese patients with systolic hypertension (SH). Methods: Patients aged ≥20 yrs with mean sitting (ms) SBP ≥150- Results: A total of 1161 patients (LCZ696 200 mg, n=387; LCZ696 400 mg, n=385; olmesartan, n=389) were randomized. Demographic and baseline characteristics were generally comparable across the treatment groups with mean age of 58.7 yrs ( Conclusion: Treatment with LCZ696 is effective and generally well-tolerated in Japanese patients with SH regardless of age and LCZ696 200 mg showed superior BP lowering effect than olmesartan 20 mg.
Construction of Enriched Resource for Primary Therapeutic Targets of Approved and Clinical Trial Drugs

An assessment of the efficacy targets of drugs that represent an opportunity for targeted therapy is fundamental to the development of post-genomic research strategies within the pharmaceutical industry. Identification and validation of efficacy target is an important process in drug discovery and development. Extensive drug discovery efforts have yielded many approved and candidate drugs. Although sever drug databases provide the drug and their corresponding targets, there is an insufficient coverage of the clinical trial drugs over the past decades. Here, we conduct a comprehensive survey for current clinical trial drugs, therapeutic targets. The analysis contents include: 1) collect clinical trial drugs from different sources, 2) By analysis of the literature, we summarize the criteria for assign therapeutic targets for each drug based on its indication. The knowledge of these drugs and their targets is useful not only for drug discovery and development of targeted therapy, but also for facilitating the discovery of systems pharmacology.
Bringing paintings to life

In the 21 century, the century of robotics and technological development, in general, school should become more competitive and appealing by moving away from the traditional and, in some cases, sterile learning process and by adopting innovative and modern practices, which eliminate the barriers between different areas of knowledge. These practices can, also, create a link between school knowledge and the world beyond the narrow boundaries of school classrooms, thus meeting students' needs and interests. Our experiential cultural programme, inspired by the Foreign Language and Art course curricula and based on the principles of interdisciplinarity, encourages students, through an experiential approach to foreign language (FL), to acquaint themselves with the artworks of great painters and various art movement proponents, and helps them to use French in speaking and writing tasks. It is intended for pupils aged 12-15 whose level of language proficiency is A2-B1, according to the Common European Framework of Reference for Languages (CEFR). What is more, it highlights the importance of the teacher's role, who by using appropriate and innovative educational and pedagogical tools, can become a fellow traveller in the journey towards knowledge acquisition.
Targeting angiogenesis in non-small cell lung cancer: Agents in practice and clinical development

AB S TRA C T Molecularly targeted therapies are becoming increasingly important in clinical oncology practice. Several critical molecular pathways have been identified, and novel therapeutic agents targeting these pathways are now approved and administered routinely in different solid malignancies. Angiogenesis, and in particular the vascular endothelial growth factor (VEGF) pathway, plays a central role in the development and progression of solid malignancies including non-small cell lung cancer (NSCLC). Agents designed to target this pathway include both antibodies targeting VEGF and small molecule tyrosine kinase inhibitors that can inhibit signaling through the VEGF receptors. A number of agents targeting the VEGF pathway have shown promising results in the treatment of NSCLC, and some, such as bevacizumab, have even been approved and are available for routine administration in combination with chemotherapy for patients with NSCLC. This is a concise review of the major angiogenic pathways and the targeted agents designed to block these pathways. The review will focus on the benefits of antiangiogenic agents that are in advanced clinical development in NSCLC, as well as the future direction of this field.
Filme com cenas de violência: efeito sobre o comportamento agressivo de crianças expresso no enredo de uma redação

A violencia na midia e seus efeitos sobre o comportamento agressivo tem recebido grande atencao de diversos segmentos da sociedade. Os efeitos de um filme com cenas de violencia sobre o comportamento agressivo de criancas foi investigado por meio da diferenca no grau de agressividade expresso em redacoes feitas antes e apos o filme. Vinte e cinco meninas e trinta e um meninos de 4a serie do Ensino Fundamental, de uma escola publica, participaram de um experimento com um delineamento intra-grupo. Primeiro, as criancas redigiram uma redacao, a partir de um enredo que iniciava uma estoria. Apos 24 h, elas assistiram ao filme Mortal Kombat exibido em sala de aula; e finalmente elas redigiram uma outra estoria, a partir de um enredo diferente. As redacoes foram julgadas por tres estudantes universitarios que nao conheciam o objetivo do estudo. Eles atribuiram notas de 0 a 10 para o grau de agressividade dos personagens das estorias, com base em criterios pessoais. A analise dos dados indica que a agressividade expressa nas redacoes pelas meninas e pelos meninos aumentou apos eles terem assistido ao filme. Estes resultados indicam que assistir filmes com cenas de violencia afeta o comportamento de criancas de ambos os sexos, quando avaliado por meio de redacoes. Palavras-chave: filme com violencia; comportamento agressivo; violencia na midia.
Effects of GLP-1 receptor agonists on arrhythmias and its subtypes in patients with type 2 diabetes: A systematic review and meta-analysis

Purpose An update of a systematic review and meta-analysis of the risk of arrhythmias and their subtypes in type 2 diabetic patients receiving glucagon-like peptide 1 receptor agonist (GLP-1RA) medication according to data from the Cardiovascular Outcome Trial(CVOT). Methods Randomized controlled trials (RCT) on GLP-1RA therapy and cardiovascular outcomes in type 2 diabetes mellitus patients published in full-text journal databases such as MEDLINE (via PubMed), Embase, Clinical Trials.gov, and the Cochrane Library from establishment to March 1, 2022 were searched. We assessed the quality of individual studies by the Cochrane risk-of-bias algorithm. RevMan 5.4. 1 software was use for calculating meta-analysis. Results A total of 60,081 randomized participants were included in the data of these 8 GLP-1RA cardiovascular outcomes trials. Pooled analysis reported no significant effect on total arrhythmia [RR=0.96, 95% CI (0.96, 1.05), p =0.36], and its subtypes such as atrial fibrillation [RR=0.96, 95% CI (0.86, 1.07), p =0.43], atrial flutter [RR= 0.82, 95% CI (0.57, 1.19), p =0.30], atrial tachycardia [RR=0.64, 95% CI (0.20, 2.01), p =0.44)], sinoatrial node dysfunction [RR=0.74, 95% CI (0.44, 1.25), p =0.26], ventricular preterm systole [RR=1.42, 95% CI (0.62, 3.26), p =0.41], second degree AV block [RR=0.96, 95% CI (0.53, 1.72), p =0.88], complete AV block [RR=0.75, 95% CI (0.49, 1.17), p =0.21], ventricular fibrillation [RR=1.00, 95% CI (0.50, 2.02), p =1.00], ventricular tachycardia [RR=1.37, 95% CI (0.91, 2.08), p =0.13] from treatment with GLP-1RA versus placebo. However, the risk of hypoglycemia was reduced by about 30% [RR=0.70, 95% CI (0.57, 0.87), p=0.001] and the risk of pneumonia by about 25% [RR=0.85, 95% CI (0.75, 0.97), p=0.01], both statistically significant differences. Conclusion In type 2 diabetic patients, treatment with GLP-1RA has no significant effect on the risk of major arrhythmias but significantly reduces the risk of hypoglycemia and pneumonia.