Miracle-dz/UniFAR-FTUs huggingface dataset:
elationship between changes in heart rate recovery after ardiac rehabilitation on cardiovascular mortality in patients ith myocardial infarction

547-5271/$ -see front matter © 2010 Published by Elsevier Inc. on behalf of H 65 bpm (HR 5.37, 95% CI 1.33–21.61, P .018), post-training RR 12 bpm (HR 2.49, 95% CI 1.10–5.63, P .028), left entricular ejection fraction 30% (HR 4.70, 95% CI 1.34–16.46, .016), and exercise capacity 4 metabolic equivalents (HR .63, 95% CI 1.17–11.28, P .026) were independent predictors f cardiac death. Patients who failed to improve HRR from 12 pm to 12 bpm after exercise training had significantly higher ortality (HR 6.2, 95% CI 1.3–29.2, P .022).
A simple technology for superjunction device fabrication: polyflanked VDMOSFET

The charge compensation based novel superjunction (SJ) MOSFET outperforms its conventional counterparts. However, the production of SJ devices is limited by a complicated and costly fabrication process. In this letter, a feasible technology for polyflanked vertical double-diffused MOS SJ structure, as in Gan et al. (2001), is introduced and demonstrated to have greatly reduced fabrication costs, simplified processes, and overcome the interdiffusion problem of SJ columns. This brings forth the new milestone that SJ MOS devices can now be fabricated by standard cleanroom facilities.
Coexistence in competing species models , I : the Neuhauser-Pacala model

This is a concise version of the lecture note for the first part of the learning session “Competing species models” held on 3rd August 2017 at the National University of Singapore1. This part is centered around the Neuhauser-Pacala model [3] in terms of methods of “Bernoulli subsystems” in [1, 4]. The second part of the session is led by Matthias Hammer and discusses related models of interacting diffusions2.
Everolimus-eluting bioresorbable vascular scaffold (BVS) implantation in patients with ST-segment elevation myocardial infarction (STEMI).

AIMS Recent studies have demonstrated favourable clinical outcomes for the everolimus-eluting bioresorbable vascular scaffold (BVS) ABSORB™ in patients with stable coronary artery disease. There are currently no data on its use in patients with ST-segment elevation myocardial infarction (STEMI). We assessed the safety and impact of BVS in the setting of primary percutaneous coronary intervention (PCI) in patients presenting with STEMI to our institution. METHODS AND RESULTS A total of 11 patients who underwent primary PCI with intent for BVS implantation between October 2012 and April 2013 at our institution were included. Median follow-up period was 53.0 ± 45.9 days. One patient presented to the hospital with cardiogenic shock and subsequently died. The other 10 patients did not have any major adverse cardiac events (MACE). There were no acute or subacute stent thromboses at short-term follow-up. CONCLUSIONS These are the first real-world data using BVS in patients with STEMI. The ABSORB™ BVS may be safely used in patients with STEMI undergoing primary PCI with favourable short-term outcome.
Evaluating an Inspection Technique for Use Case Specifications - Quantitative and Qualitative Analysis

Usability inspections in early stages of the development process help revealing problems that can be corrected at a lower cost than at advanced stages of the development. The MIT 1 (Model Inspection Technique for Usability Evaluation) is a usability inspection technique, which aims to anticipate usability problems through the evaluation of use cases. This technique was evaluated using a controlled experiment aimed at measuring its efficiency and effectiveness, when compared to the Heuristic Evaluation (HEV) method. According to quantitative results, the MIT 1 exceeded the HEV in terms of effectiveness and obtained a similar performance in terms of efficiency. In other words, the MIT 1 allows finding more problems than the HEV. On the other hand, the subjects spent more time finding these problems using MIT 1. Moreover, the MIT 1 was considered easy to use and useful by the subjects of the study. We analysed the qualitative data using the procedures from the Grounded Theory (GT) method and results indicate improvement opportunities.
Alliance and technology networks: an empirical study on technology learning

Patterns of alliance ties and patent citations, between firms in the chemical-pharmaceutical sector over a 13-year period, were mapped to draw alliance and technology networks in the industry. We then investigated how technology learning takes place in the networks. Learning was particularly high when the allies have had direct interorganisational ties, and when both allies have accessed the common pool of external or third-party knowledge. The results emphasise the importance of developing trust around direct alliance ties. There appears to be a tension however, concerning the extent to which firms should have similar or different technology profiles, in order to learn most effectively from each other. The results suggest that learning is most likely when partners are similar in their technology base at the network level, but still remain distinctive in their dyadic technology profiles.
Shielded capacitive electrode with high noise immunity

This study proposed the use of an innovative shielded capacitive sensing electrode in noncontact electrocardiograms (ECG) with high noise immunity. Capacitive ECGs are sensitive to external noise and interference such as mains power and environmental changes. Therefore, a shielded capacitive electrode designed with capacitance feedback was proposed to prevent such interference.
Molecular recognition and binding of thermal hysteresis proteins to ice

Molecular recognition and binding are two very important processes in virtually all biological and chemical processes. An extremely interesting system involving recognition and binding is that of thermal hysteresis proteins at the ice–water interface. These proteins are of great scientific interest because of their antifreeze activity. Certain fish, insects and plants living in cold weather regions are known to generate these proteins for survival. A detailed molecular understanding of how these proteins work could assist in developing synthetic analogs for use in industry. Although the shapes of these proteins vary from completely α‐helical to globular, they perform the same function. It is the shapes of these proteins that control their recognition and binding to a specific face of ice. Thermal hysteresis proteins modify the morphology of the ice crystal, thereby depressing the freezing point.
Bad-deficient mice develop diffuse large B cell lymphoma

The proapoptotic activity of the “BH3-only” molecule BAD can be differentially regulated by survival factor signaling. Bad-deficient mice lacking both BAD long and BAD short proteins proved viable, and most cell types appeared to develop normally. BAD did not exclusively account for cell death after withdrawal of survival factors, but it was an intermediate for epidermal growth factor- or insulin-like growth factor I-countered apoptosis, consistent with a “sensitizing” BH3-only molecule. Lymphocytes developed normally with no premalignant hyperplasia, but they displayed subtle abnormalities in proliferation and IgG production. Despite the minimal phenotype, Bad-deficient mice progressed, with aging, to diffuse large B cell lymphoma of germinal center origin. Exposure of Bad-null mice to sublethal γ-irradiation resulted in an increased incidence of pre-T cell and pro-/pre-B cell lymphoblastic leukemia/lymphoma. Thus, proapoptotic BAD suppresses tumorigenesis in the lymphocyte lineage.
The effect of immediate access to a computerized medical record on physician test ordering: a controlled clinical trial in the emergency room.

We performed a randomized clinical trial of the effect of immediately printed summaries of a computerized medical record on physician test ordering rates in an Emergency Room setting. The computerized medical record contained medication history, the results of most diagnostic studies, an outpatient problem list, and inpatient and emergency room diagnoses. Physicians were presented with a printed summary of the patient's computerized record for study but not for control encounters. All other patient information was equally available to both kinds of encounters. All results were provided for one period of the study, designated T1. Due to a program error, summaries were printed without recent data during a period of the study, designated T2. Two-thirds of the visits were cared for by internists, one-third by surgeons. During T1, internists ordered an average of 3.2 tests, costing $34.91 for control visits, and 2.7 tests, costing $29.94 for study control visits (p less than .026). Surgeons also ordered fewer tests during study visits as compared to controls (1.32 vs 1.54) but the differences were not statistically significant. There was no significant effect on either medical or surgical test ordering during time period T2.
Statistical analysis of the SNR loss due to imperfect time reversal

Prefiltering that is, linear processing at the transmitter side of a link, is often used in communication in order to simplify receivers, or to improve performance. Prefiltering requires at least a knowledge of the channel state. When this information is estimated, imperfect estimations impact achievable performance. Time reversal, that is a special kind of prefiltering, where channel is estimated at transmitter side during a training phase, is analyzed, in particular regarding the pattern of channel estimation errors. Results show that a loss in SNR is incurred, and a symbol error probability floor appears, depending on the variance of estimation errors. Exact theoretical expressions were derived for the SNR loss as well as symbol error probability.
RNA-dependent RNA polymerase activity in coronavirus- infected cells

An enzymatic activity which incorporates [3H]UMP into acid-precipitable material in the presence of endogenous template was found in the cytoplasm of porcine cells infected with the transmissible gastroenteritis virus of swine. This activity was not found in uninfected control cells, nor was it found in purified virus. The activity was associated with the mitochondrial fraction of infected cells, suggesting that the enzyme is membrane bound. The activity required the presence of all three ribonucleoside triphosphates in addition to [3H]UTP, and it was not inhibited by actinomycin D. The heated product was digested by RNase but not by DNase. Mg2+ was required for enzymatic activity, and its optimal concentration was approximately 5 mM. The size of the in vitro products was compared by electrophoresis with that of in vivo-synthesized virus-specified RNA to confirm the viral specificity of the polymerase activity. Virus-specified RNA from infected cells consisted of 10 species of single-stranded, polyadenylated RNA with molecular weights of 6.8 X 10(6), 6.2 X 10(6), 3.15 X 10(6), 1.40 X 10(6), 1.05 X 10(6), 0.94 X 10(6), 0.66 X 10(6), 0.39 X 10(6), 0.34 X 10(6), and 0.24 X 10(6). In vitro synthesized RNA consisted of a high-molecular-weight species, of apparently higher molecular weight than genomic RNA, and two single-stranded species that electrophoretically comigrated with the species of 1.40 X 10(6) and 0.66 X 10(6) molecular weight made in vivo.
Identifying the Relationship between Work and Nonwork Stress among Bank Managers

The purpose of this study was to (1) test the effects of various demographic and socioeconomic variables on perceived stress among bank managers in both work and nonwork environments and (2) to ascertain whether the correlation is significant between perceived stress in the work and nonwork environments among the same bank managers. Significant differences were found between genders, among management levels, and among age groups. A multiple linear regression test showed a positive relationship between perceived stress at work and away from work.
Paclitaxel and recombinant human granulocyte colony-stimulating factor as initial chemotherapy for metastatic breast cancer.

PURPOSE A phase II study of Taxol (paclitaxel; Bristol-Myers Squibb Co, Princeton, NJ) as initial chemotherapy for metastatic breast cancer was conducted. Recombinant human granulocyte colony-stimulating factor (rhG-CSF) was used to ameliorate myelosuppression, the anticipated dose-limiting toxicity. PATIENTS AND METHODS Twenty-eight patients with bidimensionally measurable breast cancer who had not received prior chemotherapy for metastatic disease were treated. Taxol was administered at 250 mg/m2 as a continuous 24-hour intravenous (i.v.) infusion every 21 days. rhG-CSF was administered at 5 micrograms/kg/d subcutaneously on days 3 through 10. RESULTS Objective responses were observed in 16 of 26 assessable patients (62%; 95% confidence interval, 41% to 80%). There were three (12%) complete responses (CRs) and 13 (50%) partial responses (PRs). Ten of 16 patients (63%) who had received prior adjuvant chemotherapy responded, which included one CR and four PRs among eight patients who had received prior doxorubicin-containing therapy. Responses were observed in all sites of metastatic disease. The median time to first objective response was 5 weeks (range, 1 to 14). Administration of rhG-CSF was associated with a short duration of neutropenia (median, 2 days with absolute neutrophil count < 500 cells/microL). Eight of 26 patients (31%) who received more than one course received subsequent therapy without dose reduction. One hundred seventy-eight cycles of treatment were administered, with a median of six cycles per patient (range, one to 19). Eight courses (4.5%) were associated with admissions for neutropenic fever. Twenty-two patients (79%) did not require admission for neutropenic fever. Treatment was well tolerated. Adverse effects included generalized alopecia in all patients. Myalgias, arthralgias, and peripheral neuropathy were mild. No hypersensitivity reactions and no cardiac toxicity were observed. CONCLUSION Taxol is highly active as initial chemotherapy for metastatic breast cancer. Administration of rhG-CSF reduced the incidence, depth, and duration of neutropenia, compared with published prior experience. Further studies of Taxol in breast cancer, including combinations with other active agents, are clearly warranted.
Thermodynamics of Abiotic Stress and Stress Tolerance of Cultivated Plants

Plants, as living systems, depend simultaneously on their internal status and their surroundings. Changes in plants’ surroundings, generated by different environmen‐ tal factors (abiotic stress), could perturb existing homeostasis, thus imposing stress. Abiotic stress includes heat, cold, freezing, flooding, drought (refers to water deficit), weak or strong light, oxygen deficiency or sufficiency, increased UV or other ionising rays, high salinity or acidity of the soil, deficiency or sufficiency of mineral elements, and presence of pollutants (xenobiotics). The effect of each abiotic factor depends on its severity, duration, developmental stage of the plant and its susceptibility to stress. During stress, requirements for energy increase (with increased intensity of respiration —domination of exergonic processes) as well as entropy. Variations in environmen‐ tal factors could push the plant’s metabolism out of homeostasis. In order to reestab‐ lish it, smaller or higher amounts of energy are required. The intention to increase the yield (grain or biomass production) of cultivated plants requires additional energy for successful completion of their life cycle, which makes them especially susceptible to stressful environments. From this point, the necessity to develop tolerant genotypes, which require less energy for maintaining homeostasis, arises.
Antimicrobial peptides in Echinoderms

Antimicrobial peptides (AMPs) are important immune effector molecules for invertebrates, including echinoderms, which lack a vertebrate-type adaptive immune system. Here we summarize the knowledge of such peptides in echinoderms. Strongylocins are a novel family of cysteine-rich AMPs, recently identified in the sea urchins, Strongylocentrotus droebachiensis and S. purpuratus. Although these molecules present diverse amino acid sequences, they share an identical cysteine arrangement pattern, dissimilar to other known AMPs. A family of heterodimeric AMPs, named centrocins, are also present in S. droebachiensis. Lysozymes and fragments of larger proteins, such as beta-thymocins, actin, histone 2A and filamin A have also been shown to display antimicrobial activities in echinoderms. Future studies on AMPs should be aimed in revealing how echinoderms use these AMPs in the immune response against microbial pathogens.
Synergy of β-Lactams with Vancomycin against Methicillin-Resistant Staphylococcus aureus: Correlation of Disk Diffusion and Checkerboard Methods

ABSTRACT Modified disk diffusion (MDD) and checkerboard tests were employed to assess the synergy of combinations of vancomycin and β-lactam antibiotics for 59 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and Mu50 (ATCC 700699). Bacterial inocula equivalent to 0.5 and 2.0 McFarland standard were inoculated on agar plates containing 0, 0.5, 1, and 2 μg/ml of vancomycin. Oxacillin-, cefazolin-, and cefoxitin-impregnated disks were applied to the surface, and the zones of inhibition were measured at 24 h. The CLSI-recommended checkerboard method was used as a reference to detect synergy. The MICs for vancomycin were determined using the Etest method, broth microdilution, and the Vitek 2 automated system. Synergy was observed with the checkerboard method in 51% to 60% of the isolates when vancomycin was combined with any β-lactam. The fractional inhibitory concentration indices were significantly lower in MRSA isolates with higher vancomycin MIC combinations (P < 0.05). The overall agreement between the MDD and checkerboard methods to detect synergy in MRSA isolates with bacterial inocula equivalent to McFarland standard 0.5 were 33.0% and 62.5% for oxacillin, 45.1% and 52.4% for cefazolin, and 43.1% and 52.4% for cefoxitin when combined with 0.5 and 2 μg/ml of vancomycin, respectively. Based on our study, the simple MDD method is not recommended as a replacement for the checkerboard method to detect synergy. However, it may serve as an initial screening method for the detection of potential synergy when it is not feasible to perform other labor-intensive synergy tests.
Rvs161p and Rvs167p, the Two Yeast Amphiphysin Homologs, Function Together in Vivo *

Mutations in RVS161 andRVS167, the two yeast amphiphysin homologs, cause very similar growth phenotypes, a depolarized actin cytoskeleton, and a defect in the internalization step of endocytosis. Rvs161p and Rvs167p have been shown to interact in the two-hybrid system, but their localization in the cell may be different thus raising the question whether the interaction is physiologically relevant. Here we demonstrate that the two proteins function together in vivo. We find that the steady state level of Rvs167p is strongly reduced in an rvs161Δ strain. Similarly, the level of Rvs161p is strongly reduced in an rvs167Δ strain. We demonstrate that these reduced protein levels at steady state are due to a decreased stability of either Rvs protein in the absence of the other protein. Furthermore, we find that the amount and ratio of Rvs161p and Rvs167p are critical parameters for receptor-mediated endocytosis. In addition, by using the two-hybrid system we show that the interaction of Rvs167p with actin is not abolished in anabp1Δ strain suggesting that Abp1p is not essential for this interaction.
Vasodilatory effect of pulsatile pressure on coronary resistance vessels.

Intramyocardial pressure becomes high in systole and decreases in diastole. Therefore, the transmural pressure of the intramyocardial vessels is pulsatile, resulting in the cyclic distension of these vessels. However, the effect of pulsatility on the behavior of the coronary resistance vessels has not been evaluated. To assess the influence of pulsatile pressure on the behavior of the coronary arterioles, we measured the luminal cross-sectional area (CSA) of coronary arterioles under cyclically changing transmural pressure. Isolated porcine coronary arterioles (internal diameter, 100 to 150 microns) were cannulated with two micropipettes and pressurized with square waves (1 Hz) through both pipettes so as not to induce flow-dependent vasodilation. During the presence (active, induced by acetylcholine; n = 7) or absence (passive, abolished by bradykinin; n = 7) of vascular tone, the CSA was measured under the following conditions: (1) The amplitude of the pressure pulse was changed at a fixed mean pressure. (2) The mean pressure was changed at a fixed pressure pulse. With increasing pulse pressure, the mean CSA at steady state increased under active conditions, whereas it decreased under passive conditions (P < .0001). This vasodilatory effect of pulse pressure remained present after endothelial denudation (P < .0001; n = 6 vessels with basal tone, n = 9 vessels with U46619-induced tone). The mean steady state CSA under passive conditions increased with the mean pressure (P < .05), whereas under active conditions it remained constant in the range of mean pressures between 50 and 100 mm Hg, reflecting myogenic responsiveness. These results indicate that an increase in amplitude of the pressure pulse dilates coronary arterioles. The vasodilating effect of the pulsation may compensate partly for the extra compressing effect of cardiac contraction on the intramyocardial vessels.
A behaviour coordination manager for a mobile manipulator

In this paper a behaviour coordination manager for a mobile manipulator is proposed. The manager activates and coordinates purposive perception-action units, so-called behaviours, of a mobile manipulator based on a task provided by a deliberative planning system. As a decision making mechanism for the behaviour coordination Bayesian belief networks are applied. The Bayesian belief networks are trained to learn the influence of the behaviours on the manipulators movement in each situation. After development, training, and testing in a virtual environment, the implemented module is transferred to a real mobile manipulator and evaluated there. Finally, experimental results are presented.
ISPAD Clinical Practice Consensus Guidelines 2014 Compendium Psychological care of children and adolescents with type 1 diabetes

Alan M Delamatera, Maartje de Witb, Vincent McDarbyc, Jamil Malikd and Carlo L Acerinie aDepartment of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA; bDepartment of Medical Psychology, EMGO Institute for Health & Care Research, VU University Medical Center, Amsterdam, Netherlands; cDepartment of Psychology, National Children’s Research Centre and Our Lady’s Children’s Hospital, Dublin, UK; dNational Institute of Psychology, Center of Excellence, Quaid-i-Azam University, Islamabad, Pakistan; and eDepartment of Paediatrics, University of Cambridge, Cambridge, UK
A compact Vivaldi antenna with microstrip feed line for the 2–18GHz ultra-wideband applications

Design of a microstrip fed double exponentially tapered Vivaldi antenna is presented for the 2-18 GHz ultra-wideband applications. Wideband operation is obtained by integrating a compact ultra-wideband balun with the antenna through an impedance transformer. Rectangular dimension of the feeding network including the balun and the matching section fabricated on a 0.813 mm thick RO4003C substrate is 100.2 mm × 82.75 mm. Measured results show that the overall input reflection loss is below 10 dB over 2-18 GHz. The antenna also maintains good gain characteristics over this band.