Miracle-dz/UniFAR-FTUs huggingface dataset:
Deformidades angulares de la rodilla tratadas con hemiepifisiodesis con animales

Objetivo: Conocer el número de casos buenos y malos al corregir deformidades angulares de rodilla con hemiepifisiodesis. Conocer si la hemiepifisiodesis es adecuada para corregir deformidades angulares. Material y métodos: Se revisaron retrospectivamente 18 deformidades angulares en 14 pacientes en el Hospital Shriners para Niños, México tratados con hemiepifisiodesis tibial proximal, en el periodo comprendido entre enero de 1995 a diciembre de 2003 que tengan un seguimiento clínico y radiológico mínimo de 24 meses. Se realizó la medición y comparación radiológica del ángulo femorotibial, al momento de la cirugía y al final del seguimiento. Se clasificaron los resultados como excelentes si llegaron a la normalidad, buenos a 5o de la normalidad y malos a más de 5o de la normalidad. Se considera normal de 6o a 12o. Resultados: El 56% (10) son del sexo masculino y 44% (8) femenino, 67% (12) con genuvalgo y 33% (6) genuvaro, no se presentaron cambios con respecto a los arcos de movilidad antes de la cirugía y al final del seguimiento. Infección 0%, todos los procedimientos se llevaron a cabo en la fisis tibial proximal, todos fueron realizados con técnica percutánea con broca. La corrección promedio fue de 11 grados (2 a 20 grados), la edad promedio fue de 11.5 años (10 a 13 años). Se obtuvo resultado excelente en 11 (61%), bueno en 4 (22%) y malo en 3 (17%). Discusión: La hemiepifisiodesis es un procedimiento con menor morbilidad que una osteotomía alineadora y ofrece una rehabilitación precoz posoperatoria al no requerir inmovilización. El número de complicaciones es menor con la hemiepifisiodesis. La hemiepifisiodesis requiere cálculo de la edad a la que se realizará la cirugía. Conclusión: Se obtuvo 61% de resultados excelentes con la hemiepifisiodesis. La hemiepifisiodesis es una alternativa para el tratamiento de las deformidades angulares de rodilla.
Marco, Timbo, and Chaco, newly recognized arboviruses from lizards of Brazil.

Summary Marco, Timbo and Chaco are three newly recognized arboviruses isolated from pools of heart and liver of lizards captured near Belem, Para, Brazil. Four strains of Marco virus, six of Timbo and three of Chaco were detected in Ameiva ameiva ameiva. A fourth strain of Chaco virus was isolated from Kentropyx calcaratus. No serological relationship of Marco virus to other arboviruses has so far been demonstrated. Timbo and Chaco cross-react in complement-fixation testing but have not been shown to be related to any other arbovirus. These viruses have not been recovered from birds, amphibians, rodents, marsupials, primates, bats, edentates, carnivores, horses, cattle or arthropods in the Amazon region, and it is proposed that the lizard is their principal vertebrate host.
5‐HT3 receptor channels in dissociated rat superior cervical ganglion neurons.

1. Whole‐cell and single‐channel voltage‐clamp techniques were used to record the 5‐HT3 receptor‐mediated currents in neurons freshly dissociated from rat superior cervical ganglia. 2. Whole‐cell currents elicited by brief pressure ejection of 5‐HT (10 microM) reversed at ‐4.5 mV when extracellular and intracellular solutions mainly contained NaCl and CsCl. The peak current‐voltage relation showed modest inward rectification that was fully developed within less than 2 ms of the applied voltage step. 3. With prolonged application of 5‐HT (10 microM) using a fast perfusion system, the response desensitized in two phases with fast and slow time constants of 0.57 and 6.0 s at ‐74 mV. The time constants showed little voltage dependence; however, the relative amplitude of the two components was significantly dependent on voltage. The time course of desensitization was not affected by agents that increase the levels of intracellular cyclic AMP. 4. The relative permeability of the channel was determined from reversal potential changes. The channel passed small cations non‐selectively, with permeability ratios (PX/PNa) of 0.93 and 1.24 for Cs+ and K+. The organic cations Tris and glucosamine were measurably permeant with permeability ratios of 0.19 and 0.06. Ca2+ was fairly permeant with a relative permeability of 0.55 in 20 mM solution and of 0.16 when the concentration of CaCl2 was increased to 115 mM. No permeability was detected for Cl‐. 5. Fluctuation analysis of the whole‐cell current revealed an apparent single‐channel current of approximately 0.18 pA at ‐74 mV. 6. 5‐HT‐activated single‐channel currents were recorded in excised outside‐out patches. When 5‐HT (10 microM) was delivered by pressure ejection, channel openings appeared rapidly with a delay of 28 ms. The unitary current was about approximately 0.80 pA at ‐74 mV. The channel activity induced by bath perfusion of 5‐HT (0.8 microM) was significantly reduced by 100 nM of the 5‐HT3 receptor‐specific antagonists 3‐tropanyl‐3,5‐dichlorobenzoate (MDL 72222) or 3‐tropanyl‐indole‐3‐carboxylate (ICS 205‐930). 7. The single‐channel current‐voltage relation was non‐linear, with moderate inward rectification similar to that of the whole‐cell current. The chord conductance of the channel decreased with membrane depolarization from 14.6 pS at ‐104 mV to only 9.9 pS at ‐54 mV. Open‐time distributions consisted of two components with mean time constants of 0.45 and 2.8 ms at ‐104 mV. Burst‐length distributions were also made up of two components with time constants of 0.45 and 4.6 ms.(ABSTRACT TRUNCATED AT 400 WORDS)
Multipath routing algorithm for application‐specific wormhole NoCs

Adaptive routing designing for network‐on‐chip architecture is complicated to guarantee deadlock‐free. In this paper, we present methodology to design efficient multi‐path routing algorithms for specific application wormhole network‐on‐chip system to guarantee deadlock‐free. The methodology presents an analytical model for overall average delay of wormhole network‐on‐chip by queueing theory and uses a linear programming–based methodology to minimize overall average delay. The methodology guarantees deadlock freedom by efficient branch‐and‐bound algorithm. Compared to other adaptive deadlock‐free algorithms, results obtained through simulation show that the algorithms can potentially achieve better throughput and latency.
Nitrate‐induced coronary vasodilation by stress‐magnetic resonance imaging: A novel noninvasive test of coronary vasomotion

To evaluate the feasibility of assessing coronary vasodilation following exogenous nitrates, using magnetic resonance angiography (MRA). The assessment of coronary response to exogenous nitrovasodilators may have a diagnostic and prognostic impact in patients with coronary artery disease. To date, stress imaging of coronary artery vasomotion has been confined to the catheterization laboratory. MRA is emerging as a noninvasive tool for coronary artery imaging.
Promoter methylation patterns in Richter syndrome affect stem‐cell maintenance and cell cycle regulation and differ from de novo diffuse large B‐cell lymphoma

In a fraction of patients, chronic lymphocytic leukaemia (CLL) can transform to Richter syndrome (RS), usually a diffuse large B–cell lymphoma (DLBCL). We studied genome‐wide promoter DNA methylation in RS and clonally related CLL‐phases of transformed patients, alongside de novo DLBCL (of non‐germinal centre B type), untransformed‐CLL and normal B‐cells. The greatest differences in global DNA methylation levels were observed between RS and DLBCL, indicating that these two diseases, although histologically similar, are epigenetically distinct. RS was more highly methylated for genes involved in cell cycle regulation. When RS was compared to the preceding CLL‐phase and with untransformed‐CLL, RS presented a higher degree of methylation for genes possessing the H3K27me3 mark and PRC2 targets, as well as for gene targets of TP53 and RB1. Comparison of the methylation levels of individual genes revealed that OSM, a stem cell regulatory gene, exhibited significantly higher methylation levels in RS compared to CLL‐phases. Its transcriptional repression by DNA methylation was confirmed by 5‐aza‐2′deoxycytidine treatment of DLBCL cells, determining an increased OSM expression.
Anxiety, depression, and quality of life in caregivers of patients with cancer in late palliative phase.

BACKGROUND Limited research has been done on mental health and health-related quality of life (QOL) of primary caregivers (PCs) to patients staying at home with advanced cancer. This study examines anxiety, depression, and QOL in PCs of patients with cancer in the late palliative phase. PATIENTS AND METHODS The sample consisted of 49 PCs of women with breast cancer and 47 PCs of men with prostate cancer. QOL was rated with the Medical Outcome Study Short Form (SF-36), and mental health with the Hospital Anxiety and Depression Scale (HADS). The findings were compared with age-adjusted norm data (norm). RESULTS Physical QOL was significantly higher than norm in both genders, while mental QOL was significantly lower in male PCs. The level of anxiety was significantly higher than norm in both genders. No significant difference for level of depression was found in either gender, while caseness of HADS-defined depression was significantly more prevalent in female PCs compared with norm. CONCLUSION PCs of both genders had significantly more anxiety than norm samples. Health care personnel in contact with PCs should consider screening them for mental symptoms and QOL and, if necessary, recommend further evaluation by their doctors.
New way for functional analyzing of Deflation Detection System in a Hardware-In-the-Loop environment

The article presents an automated verification method of the Continental indirect tire pressure monitoring system in a Hardware-In-the-Loop (HIL) environment. For the test procedure a precise real-time system is necessary, which allows the evaluation of the outputs as the respond of the generated inputs by the test-engineer, and ensures the continuous observation. The prescribed test cases are separated into logically built groups, and these together produced a so called general test package. This method gives a possibility to indicate software deviations before it will be implemented in a vehicle. Deflation Detection System (DDS) [1], [2] and the applied HIL test environment have been developed, respectively used by Continental — they are not part of the results of this work. The article depicts the results of how the latter one could be applied to analyze DDS behavior.
Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity

Adenovirus E1A transforming function requires two distinct regions of the protein. Transforming activity is closely linked with the presence of a region designated conserved domain 2 and the ability of this region to bind the product of the cellular retinoblastoma tumor suppressor gene. We have investigated the biological properties of the second transforming region of E1A, which is located near the N terminus. Transformation-defective mutants containing deletions in the N terminus (deletion of residues between amino acids 2 and 36) were deficient in the ability to induce DNA synthesis and repress insulin enhancer-stimulated activity. The function of the N-terminal region correlated closely with binding of the 300-kilodalton E1A-associated protein and not with binding of the retinoblastoma protein. These results indicate that transformation by E1A is mediated by two functionally independent regions of the protein which interact with different specific cellular proteins and suggest that the 300-kilodalton E1A-associated protein plays a major role in E1A-mediated cell growth control mechanisms.
Burrow-centric distance-estimation methods inspired by surveillance behavior of fiddler crabs

There are several ways to estimate the distance to an object based on visual information. Many robotic systems compute object distances based on disparity values or motion information. In addition to a disparity cue or image motion, research has shown that animals can possibly estimate the distance using the image size as well as the azimuth and elevation angles in their visual field. In this paper, inspired by the vigilance behavior of fiddler crabs, we suggest distance-estimation methods with several visual cues for engineering applications. A foraging fiddler crab can estimate the distance of an intruder from the burrow entrance. If the intruder is close to the burrow, the crab rushes back home to maintain possession of the burrow. In this study, we investigated burrow-centered distance-estimation methods based on visual information such as the retinal position, that is, the azimuth and elevation angles in an omnidirectional view as well as the image size and retinal speed of a target object. The methods show potential for engineering applications to the surveillance problem.
[Development of resistance to beta-lactams and other antibiotics of pneumococci isolated from acute otitis media in France: statement of the National Reference Center 1995-1996].

POPULATION AND METHODS During 1995 and 1996, 393 and 566 strains of Streptococcus pneumoniae, isolated from acute otitis media, were respectively sent to the National Reference Center for Pneumococci by its corresponding centers. RESULTS The resistance rates for 1995 and 1996 were respectively: for penicillin: 65.4 and 70.3% (18.6 and 24.9% of intermediately resistant strains, 46.8 and 45.4% of fully resistant strains), for erythromycin: 57.5 and 68.5%, for tetracycline: 43.2 and 42.6%, for trimethoprim-sulfamethoxazole: 47.5 and 50.9%. Minimal inhibitory concentrations (MICs) of various betalactams were determined against a representative sample of strains (n = 99). CONCLUSION Amoxicillin, cefpodoxime and cefuroxime MICs remained low against numerous penicillin resistant strains, indicating that these three oral antibiotics (in combination with clavulanate for amoxicillin) have a useful potential for the treatment of acute otitis media when risk factors for pneumococcal penicillin-resistant infections are detected.
Psychosocial Impact of the Implantable Cardioverter Defibrillator: Nursing Implications

Sudden cardiac death (SCD) remains a significant problem despite an overall reduction in other cardiac related deaths in recent years. Research supports the use of the implantable cardioverter defibrillator (ICD) as an effective means of treating dangerous ventricular tachydysrhythmias to prevent SCD. The issue that demands increasing attention is the psychologic experience of ICD recipients. Although the ICD is clearly a technological success, there is evidence that recipients experience strong physical and emotional reactions to the device. Such quality of life issues are worthy of a multidisciplinary effort directed at facilitating patient acceptance and adaptation to technology that although potentially life-saving, may also be unpredictable and anxiety provoking.
Photochemical Regulation of Restriction Endonuclease Activity

Removal by the light: The photochemical regulation of restriction endonucleases, which are important enzymes in molecular biology, has been investigated. Photolabile protecting groups have been installed on DNA substrates and have been demonstrated to inhibit restriction endonuclease activity until removed by UV light irradiation. Interestingly, these groups do not appear to dramatically affect initial binding of the enzyme to the DNA substrate, but rather prevent recognition of the specific cleavage site.
Model Adaptation for Dialog Act Tagging

In this paper, we analyze the effect of model adaptation for dialog act tagging. The goal of adaptation is to improve the performance of the tagger using out-of-domain data or models. Dialog act tagging aims to provide a basis for further discourse analysis and understanding in conversational speech. In this study we used the ICSI meeting corpus with high-level meeting recognition dialog act (MRDA) tags, that is, question, statement, backchannel, disruptions, and floor grabbers/holders. We performed controlled adaptation experiments using the Switchboard (SWBD) corpus with SWBD-DAMSL tags as the out-of-domain corpus. Our results indicate that we can achieve significantly better dialog act tagging by automatically selecting a subset of the Switchboard corpus and combining the confidences obtained by both in-domain and out-of-domain models via logistic regression, especially when the in-domain data is limited.
OSTEOCHONDRITIS IN CONGENITAL DISLOCATION AND SUBLUXATION OF THE HIP.

In this review of 106 cases it appears that immobilisation of a contracted, dislocated or subluxated hip in an extreme position in plaster as the initial treatment caused vascular damage to the femoral epiphysis in approximately 50 per cent of cases. Preliminary frame reduction in the dislocated hips slowly stretches the soft tissues and allows adaptation of the vessels to the position required for reduction. Open reduction would seem to reduce the incidence of osteochondritic changes. When a hip is immobilised in plaster the extreme of any position, particularly with regard to rotation, should be avoided.
Legal control of computer crime in Hong Kong

One of the main aims of information systems security (ISS) is to prevent unauthorized access to and tampering with information systems resources. In April 1993 the first ever computer crime legislation came into existence in Hong Kong. Issues relating to computer fraud, hacking, and other types of threats to ISS are addressed by the legislation. As a legislative tool used in the control of computer crime, the Hong Kong experience is worth examining because it is the first major effort of this kind in the important and fast growing Far East region. In critically examining this legislation and its implications on ISS management, contributes towards a better understanding of the regulatory control of computer crime and its policy implications. Makes comparisons with countries which have a longer history of computer crime control.
Morning report: an Australian experience

In January 2001, a daily morning handover meeting (“morning report”), involving medical staff and students, began at the Launceston General Hospital, Tasmania. Periodic questionnaire surveys have been conducted to assess whether the morning report is fulfilling the quality improvement and educational needs of medical staff. The format of meetings has been successively modified in response to feedback. Participants have expressed a preference for patient‐focused meetings, with less emphasis on formal teaching. A 12‐month pilot study beginning in January 2004 has assessed the impact of adding a bed‐management focus to the morning report. Over the period of the pilot study, there has been reduced bed access block, reduced average length of stay and increased bed availability. This suggests that a longer, more formal study may be warranted.
Postoperative statin use and risk of biochemical recurrence following radical prostatectomy: Results from the SEARCH database

Objective— • To investigate the effect of postoperative statin use on biochemical recurrence (BCR) in PC patients treated with radical prostatectomy (RP) who never used statins before surgery. Patients and Methods— • We conducted a retrospective analysis of 1,146 RP patients within the Shared Equal Access Regional Cancer Hospital (SEARCH) database. models stratified the association of postoperative statin use with BCR and non-black Results— • After adjusting for clinical and pathological characteristics, postoperative statin use was significantly associated with 36% reduced risk of BCR (HR 0.64; 95%CI 0.47-0.87; p=0.004). • Postoperative statin use remained associated with reduced risk of BCR after adjusting for preoperative serum cholesterol levels. • In secondary analysis, following stratification by race, this protective association was significant in non-black (HR 0.49; 95%CI 0.32-0.75; p=0.001) but not black men (HR 0.82; 95%CI 0.53-1.28; p=0.384). Conclusion— • In this retrospective cohort of men undergoing RP, postoperative statin use was significantly associated with reduced risk of controlled
Advances in information technology for Smart Grids

This article discusses recent trends in Smart Grid technology. Three selected aspects are (1) distributed information technology (IT), used for smart metering and multi-agent based controls, (2) big-data, resulting out of metering, sensors and other IT-enabled sources of information, and (3) an intelligent demand side, where demand response serves as contribution to grid services. New elements in the grid, most notably large numbers of fluctuating renewable energy sources, and new functionality like markets make it necessary to introduce methods and technologies from other domains that already faced such changes.
Antimicrobial and Mechanical Properties of Dental Resin Composite Containing Bioactive Glass

Background The aim of this study was to evaluate the antimicrobial efficacy and mechanical properties of dental resin composites containing different amounts of microparticulate bioactive glass (BAG). Methods Experimental resin composites were prepared by mixing resin matrix (70% BisGMA and 30% TEGDMA) and inorganic filler with various fractions of BAG to achieve final BAG concentrations of 5, 10 and 30 wt%. Antimicrobial efficacy was assessed in aqueous suspension against Escherichia coli, Staphylococcus aureus and Streptococcus mutans and in biofilm against S. mutans. The effect of incorporation of BAG on the mechanical properties of resin composite was evaluated by measuring the surface roughness, compressive strength and flexural strength. Results Under the dynamic contact condition, viable counts of E. coli, S. aureus and S. mutans in suspensions were reduced up to 78%, 57% and 50%, respectively, after 90 minutes of exposure to disc-shaped composite specimens, depending on the BAG contents. In 2-day-old S. mutans biofilm, incorporation of BAG into composite at ratios of 10% and 30% resulted in 0.8 and 1.4 log reductions in the viable cell counts compared with the BAG-free composite, respectively. The surface roughness values of composite specimens did not show any significant difference (p>0.05) at any concentration of BAG. However, compressive and flexural strengths of composite were decreased significantly with addition of 30% BAG (p<0.05). Conclusions The results demonstrated the successful utilization of BAG as a promising biomaterial in resin composites to provide antimicrobial function.
Rapid Fabrication of Living Tissue Models by Collagen Plastic Compression: Understanding Three-Dimensional Cell Matrix Repair In Vitro.

OBJECTIVE To produce biomimetic collagen scaffolds for tissue modeling and as tissue-engineered implants. APPROACH Control of collagen fibril material parameters in collagen hydrogel scaffolds by using plastic compression (PC), resulting in direct control of cell proliferation, cell migration, and cell-cell interaction. RESULTS We were able to control the density of collagen in such scaffolds from between 0.2% and 30%, and controllably layer the fibrils in the Z-plane. Cell migration was observed in gels where a gradient of collagen density was present. In these gels, cells preferentially migrated toward the collagen-dense areas. Cell proliferation rates were measurably higher in dense collagen gels. INNOVATION The use of PC to control material properties of collagen hydrogels results in collagen scaffolds that are biomimetic. These collagen gels reproduce the relevant matrix-mechanical environment in which behavior is more representative of that found in vivo. CONCLUSION The material properties of native collagen type I gels can be engineered to match those found in tissues in vivo to elicit more biomimetic cell behavior.