Miracle-dz/UniFAR-FTUs huggingface dataset:
Eosinophil Chemotactic Factor‐L (ECF‐L) Enhances Osteoclast Formation by Increasing ICAM‐1 Expression

Abstract: Eosinophil chemotactic factor‐L (ECF‐L) is a novel stimulator of osteoclast (OCL) formation that acts at the differentiation/fusion stage of OCL formation, and is a cofactor for RANK ligand (RANKL). We examined the effects of ECF‐L on the intracellular signaling pathways utilized by RANKL, and on the expression of ICAM‐1/LFA‐1 to determine its mechanism of action. RAW 264.7 and bone marrow cells were treated with RANKL and/or ECF‐L Fc protein to determine their effect on NF‐κB and AP‐1 activity. ECF‐L by itself only modestly increased NF‐κB binding and JNK activity in RAW 264.7 cells, which were further enhanced by RANKL. In contrast, ECF‐L Fc increased LFA‐1α and ICAM‐1 mRNA levels 1.8‐fold in mouse marrow cultures, and anti‐ICAM‐1 almost completely inhibited OCL formation induced by 10−10 M 1,25‐(OH)2D3, and ECF‐L Fc. Furthermore, ECF‐L Fc did not enhance OCL formation by ICAM‐1 knockout (KO) cells. Increased expression of ICAM‐1 by ECF‐L appears to be critical for its effects on OCL formation.
A study of the role of nature conservation law enforcement officers as facilitators of environmental education

This study explores the potential roles of a sample of 18 nature conservation law enforcement officers, as facilitators of environmental education. More specifically it examines their attitudes towards their dual duties of enforcing laws and providing extension services. Attitudes were examined by means of qualitative data analysis from semi-structured interviews. Officers' environmental attitudes, as well the relative emphasis placed on law enforcement and extension, and their own perspectives of working with communities, are explored. The historical and cultural context of officers' work, as well as worldviews and personality traits are also discussed. Certain recommendations regarding officers' roles as facilitors of environmental education are made. ii
A Highly Efficient Quantitative Transaction Data Mining Model

This paper focused on discrete time Geo/G/1 queue with Bernoulli gated service. We proposed a new algorithm to calculate stock's money flow by the probability generating function (P.G.F.) of stationary waiting time and stationary queue length. We did program by data mining of a variety of stock trading. The new algorithm could get any stock's money flow. We have established a series of quantitative trading strategies based on the new money flow model. These strategies could guide investors to grasp an upward trend or avoid a down trend. The quantitative investment trading strategies can be automated trading. It could reduce investors' subjective operability and increase return rate. The new algorithm was suitable for index trading, futures trading, stock trading, and ETF trading.
Role of CD36 in membrane transport of long-chain fatty acids

CD36 is a multispecific membrane glycoprotein that has been postulated to have a variety of functions. Evidence generated in isolated cells and in mice and rat models of altered CD36 expression has indicated an important role for CD36 in membrane transport of long-chain fatty acids. The cumulative data indicate that CD36 facilitates a major fraction of fatty acid uptake by muscle and fat, and that CD36 deficiency is associated with a large (60-80%) defect in fatty acid uptake by those tissues. In humans, polymorphisms in the CD36 gene may underlie defective fatty acid metabolism and some forms of heart disease. Herein we review our current understanding of the transport function and regulation of CD36. The realization that the transport step rate limits cellular fatty acid utilization suggests that abnormalities in CD36 expression or function may impact on susceptibility to certain metabolic diseases such as obesity and insulin resistance.
Correlates of medical and legal help seeking among women reporting intimate partner violence.

OBJECTIVE To examine the relationship between intimate partner violence (IPV) type, severity, and duration and abused women's use of medical and legal services. METHODS Participants were 1509 randomly sampled women from a large health plan who were interviewed by telephone to assess (1) self-reported lifetime exposure to IPV type (physical, sexual, and psychological), severity, and duration and (2) women's use of medical and legal services (civil protection orders). RESULTS Compared with women who experienced psychological abuse only, sexually abused women were 1.3 times as likely to seek medical care, and women exposed to physical IPV or sexual IPV were 3.2 times and 1.6 times as likely, respectively, to seek legal services. Rates of medical and legal help seeking increased with increasing abuse severity among physically abused women, and rates of legal help seeking increased with abuse severity among sexually and psychologically abused women. Longer duration of physical and sexual IPV was also found to be associated with increased legal help seeking. CONCLUSIONS Abused women who sought formal help were more likely to be exposed to physical or sexual IPV, severe psychological IPV, and severe and long-lasting physical and sexual IPV. Efforts should be considered to improve the healthcare and legal system's response to IPV.
Factors affecting the absorption of iron from cereals

1. Non-haem-iron absorption from a variety of cereal and fibre meals was measured in parous Indian women, using the erythrocyte utilization of radioactive Fe method. 2. The present study was undertaken to establish whether alteration of the phytate and polyphenol contents of sorghum (Sorghum vulgare) affected Fe absorption from sorghum meals, and to assess the influence of fibre on Fe absorption. 3. Removing the outer layers of sorghum grain by pearling reduced the polyphenol and phytate contents by 96 and 92% respectively. This treatment significantly increased the geometric mean Fe absorption from 0.017 to 0.035 (t 3.9, p < 0.005). 4. The geometric mean Fe absorption from a sorghum cultivar that lacked polyphenols (albino sorghum) was 0.043, which was significantly greater than the 0.019 absorbed from bird-proof sorghum, a cultivar with a high polyphenol content (t 2.83, p < 0.05). 5. Fe was less well absorbed from the phytate-rich pearlings of the albino sorghum than from the pearled albino sorghum (0.015 v. 0.035 (t 8.4, P < 0.0005)). Addition of sodium phytate to a highly Fe-bioavailable broccoli (Brassica oleracea) meal reduced Fe absorption from 0.185 to 0.037. 6. The geometric mean Fe absorption from malted sorghum porridge was 0.024 when 9.5 mg ascorbic acid were added and 0.094 when the ascorbic acid was increased to 50 mg (t 3.33, P < 0.005). This enhancing effect of 50 mg ascorbic acid was significantly depressed to 0.04 by tea (t 38.1, P < 0.0005). 7. Wheat bran significantly decreased the geometric mean Fe absorption from white flour from 0.116 to 0.043 (t 7.2, P < 0.0005). 8. Some of the constituents of the dietary fibre complex, such as apple pectin, guar gum, gum tragacanth and microcrystalline cellulose did not inhibit Fe absorption. On the other hand, hemicellulose and lignin decreased absorption. The geometric mean absorption of Fe given with hemicellulose was 0.079 v. 0.269 with microcrystalline cellulose (t 2.95, P < 0.05). Addition of cocoa, which contains approximately 280 g lignin/kg, reduced the geometric mean Fe absorption from milk from 0.075 to 0.035 (t 2.7, P < 0.05).
Determining prevalence and correlates of psychiatric treatment with Andersen's behavioral model of health services use.

OBJECTIVE This study examined the prevalence and correlates of use of health professional services for the treatment of mental or emotional problems by using Andersen's Behavioral Model of Health Services Use. METHODS In the 2007 Behavioral Risk Factor Surveillance System 169,546 community-dwelling respondents from 35 states, the District of Columbia, and Puerto Rico answered questions about their sociodemographic characteristics; perceived need; nonspecific psychological distress, as measured with the Kessler-6 scale; and use of professional treatment of mental or emotional problems. RESULTS Evaluated need (psychological distress) was significantly associated with receipt of treatment for mental or emotional problems, as were predisposing factors (age, gender, race or ethnicity, marital status, and education), enabling and impeding factors (income, health insurance, and emotional support), and perceived need (number of mentally and physically unhealthy days and self-rated health). CONCLUSION Constituents in the public mental health system should seriously consider that health services utilization is socially patterned and not just an individual behavior.
Using social media to forecast electoral results: a review of the state of the art

The paper discusses the advantages of using Supervised Aggregated Sentiment Analysis (SASA) of social media to forecast electoral results and presents an extension of the ReadMe method (Hopkins and King, 2010), which is particularly suitable to addressing a large number of categories (e.g. parties) providing lower standard errors. We analyze the voting intention of social media users in several elections held between 2011 and 2013 in France, Italy, and the United States. We then compare 80 electoral forecasts made using these or other techniques of data-mining and sentiment analysis. The comparison shows that the choice of the method is crucial. Electoral forecasts are also more accurate in countries with higher Internet penetration and given the presence of electoral systems based on proportional representation.
Sagittal alignment and the Bryan cervical artificial disc.

OBJECT The authors evaluated cervical spine radiographs to determine sagittal alignment in patients who underwent one- or two-level arthroplasty with the Bryan cervical artificial disc prosthesis. METHODS The curvature of the surgically treated spinal segments and the overall curvature of the cervical spine were evaluated in 13 patients who underwent 16 cervical arthroplasty device placements. Preoperative and postoperative lateral radiographs were reviewed and compared using standardized techniques for measuring spinal curvature. Patients who underwent a single-level cervical arthroplasty had a 4.7 degrees mean reduction (p < 0.05) in lordosis after cervical artificial disc replacement. The three patients who underwent two-level cervical arthroplasty had no significant changes in the sagittal alignment. CONCLUSIONS Patients who underwent arthroplasty with a Bryan cervical artificial disc had a focal loss of lordosis (that is, kyphosis) at the treated levels after single-level procedures. Nevertheless, there was no significant change in the overall sagittal curvature of the cervical spine after single-level artificial disc replacements. The patients who underwent two-level artificial disc placement had no significant changes in lordosis at the treated levels or in the overall curvature. The likely source of this outcome appears to be the endplate milling procedures that reorient the vertebral endplates.
Is quality of life poorer for older adults with HIV/AIDS? International evidence using the WHOQOL-HIV

Abstract Increasingly older adults are being diagnosed with HIV/AIDS. In 2002, UNAIDS indicated that 13 aspects of quality of life (QoL) were poorer for older adults, but only sparse, inconsistent cross-cultural evidence is available. This statement was investigated using a reliable, valid measure (the WHOQOL-HIV) distributed in nine cultures (eight countries). HIV positive and well adults (n = 2089) were assessed across 30 QoL facets; 403 were 40+ years. It was confirmed that sleep, fatigue and sex-life were poorer areas of QoL for older HIV adults than younger. Furthermore, they could be misinterpreted as normal ageing signs. Moreover, older people reported greater dependency on medication. However, older HIV adults had better QoL than expected on 11 dimensions; negative feelings, social inclusion, and several environmental and spiritual facets. This highlights the extent of poor QoL in younger adults. After accounting for culture and gender, overall QoL and health in older HIV adults was explained by eight facets comprising 61.3% of the variance. Social relationships were paramount, especially personal relationships (41%), but support and sex-life also. Energy, negative feelings, cognitions, financial resources and HIV symptoms also contributed. Social interventions for ageing communities would improve well-being. This evidence could support global ageing and HIV policy.
Recurrence of bacterial vaginosis is significantly associated with posttreatment sexual activities and hormonal contraceptive use.

BACKGROUND Bacterial vaginosis (BV) recurrence posttreatment is common. Our aim was to determine if behaviors were associated with BV recurrence in women in a randomized controlled trial (RCT). METHODS Symptomatic 18- to 50-year-old females with BV (≥3 Amsel criteria and Nugent score [NS] = 4-10) were enrolled in a 3-arm randomized double-blind RCT Melbourne Sexual Health Centre, Australia, in 2009-2010. All 450 participants received oral metronidazole (7 days) and were equally randomized to vaginal clindamycin, lactobacillus-vaginal probiotic or vaginal placebo. At 1, 2, 3, and 6 months, participants self-collected vaginal smears and completed questionnaires. Primary endpoint was NS = 7-10. Cox regression was used to estimate hazard ratios (HRs) for risk of BV recurrence associated with baseline and longitudinal characteristics. RESULTS Four hundred four (90%) women with postrandomization data contributed to analyses. Cumulative 6-month BV recurrence was 28% (95% confidence interval [CI], 24%-33%) and not associated with treatment. After stratifying for treatment and adjusting for age and sex frequency, recurrence was associated with having the same pre-/posttreatment sexual partner (adjusted HR [AHR] = 1.9; 95% CI, 1.2-3.0), inconsistent condom use (AHR = 1.9; 95% CI, 1.0-3.3), and being non-Australian (AHR = 1.5; 95% CI, 1.0-2.1), and halved with use of an estrogen-containing contraceptive (AHR = 0.5; 95% CI, .3-.8). CONCLUSIONS Risk of BV recurrence was increased with the same pre-/posttreatment sexual partner and inconsistent condom use, and halved with use of estrogen-containing contraceptives. Behavioral and contraceptive practices may modify the effectiveness of BV treatment. CLINICAL TRIALS REGISTRATION ACTRN12607000350426.
Tumor above the spinal accessory nerve in papillary thyroid cancer that involves lateral neck nodes: a common occurrence.

OBJECTIVE To describe the nature and extent of lateral neck node metastases from papillary thyroid cancer in relation to presenting physical examination and staging radiologic studies. DESIGN Retrospective study. SETTING Tertiary referral cancer center. PATIENTS Consecutive patients who underwent comprehensive neck dissection with or without concurrent thyroidectomy for well-differentiated thyroid cancer between 1991 and 2001. Excluded were patients with well-differentiated thyroid cancer diagnosed incidentally at the time of treatment of other primary head and neck cancer, those with previous neck dissection for nonthyroid malignancies, and those undergoing surgery for medullary thyroid cancer. INTERVENTIONS All pathology and operative and preoperative radiology reports for patients undergoing comprehensive neck dissection for well-differentiated thyroid malignancy were reviewed. Data were collected on previous procedures, preoperative evaluation, operative details, and pathologic findings. MAIN OUTCOME MEASURE Identification of metastatic thyroid cancer in one or more nodes in anatomically defined drainage basins of the central and lateral neck. RESULTS A total of 51 neck dissections were performed. All patients had preoperative evidence of metastatic disease. In addition to the usual comprehensive node dissection encompassing all lymphatic tissue in levels II through V, level I nodes and level II nodes above the spinal accessory nerve were labeled as distinct regions in 16 (31%) and 34 (67%) specimens, respectively. Disease was confined to a single nodal level in 20 (39%) of 51 specimens and was present in 4 or more levels in 7 (14%) of 50 neck dissections. There was cancer at 2 or 3 levels in 16 (31%) and 15 (29%) cases, respectively. Seven (21%) of the 34 patients undergoing separate analysis of nodes from above the spinal accessory nerve had cancer there. In 3 of the 34 it was the sole disease in level II. CONCLUSIONS Tumor involvement at multiple nodal levels occurs in most cases when patients have lateral cervical node metastases. "Skip" metastases and cancer above the spinal accessory nerve are common. Neck dissections should include all node stations likely to be involved because selective node excision is likely to leave metastatic disease in situ.
Use of corticosteroids and the outcome of infants with bronchopulmonary dysplasia.

UNLABELLED Ventilator-dependent premature infants are often treated with dexamethasone. Several trials showed that steroids while improve pulmonary compliance and facilitate extubation, some treated infants may have adverse effects, such as alterations of growth curves. We conducted this retrospective study to evaluate the effects of steroids on mechanical ventilation, oxygen therapy, hospital length stay and mortality, in ventilator-dependent infants with bronchopulmonary dysplasia (BPD) (defined as the need of oxygen supplementation at 28 days of life). Twenty-six newborns with BPD were evaluated during 9 - 42 days postpartum (mean = 31 days) and were divided into two groups: Group I - 14 newborns that did not receive dexamethasone, and Group II - 12 newborns that received dexamethasone at 14 - 21 days of life. Dexamethasone was given at a dose of 0.25 mg per kilogram of body weight twice daily intravenously for 3 days, after which the dose was tapered. RESULTS There were no statistically significant differences in the mean length of mechanical ventilation (Group I - 37 days, Group II - 35 days); oxygen supplementation (Group I - 16 days, Group II - 29 days); hospital stay (Group I - 72 days, Group II - 113 days); mortality (Group I - 35.7%, Group II - 41.6%). At birth, Group II was lighter (BW: Group I - 1154 grams +/- 302, Group II - 791 grams +/- 165; p < 0.05) and smaller (height: Group I - 37.22 cm +/- 3.3, Group II - 33.5 +/- 2.4; p< 0.05) than Group I. At 40 weeks, there were no statistically significant differences between groups in relation to anthropometric measurements. CONCLUSIONS The use of corticosteroids in bronchopulmonary dysplasic infants may influence the somatic growth during its use. However, after its suspension, a recovery seems to occur, suggesting that its influence could be transitory.
Evidence for Adhesive Activity of the Ventrolateral Flange in Giardia lamblia

Abstract Giardia lamblia is an intestinal protozoan that inhabits the intestinal tract of man and other mammals by attaching to the mucosal surface via the contractile activity of an attachment organelle called the ventral adhesive disk. We have investigated the presence of other attachment mechanisms in G. lamblia trophozoites by using microfabricated substrates that sterically interfere with formation of the hypothesized “negative pressure” under the ventral adhesive disk that would mediate attachment to a substratum. Pillars measuring 1 μm high and 2 μm in diam. were constructed in microarrays with spacings smaller than the diameter of the ventral adhesive disk. Using high resolution field emission scanning electron microscopy, the attachment of trophozoites to the tops of pillars in the microfabricated substrates was investigated. Firm adhesion of trophozoites was observed to be mediated by direct attachment of the ventrolateral flange membrane to the tops of microfabricated pillars. Attachment to microfabricated surfaces was 16% of that observed for attachment mediated by the ventral adhesive disk (4.4 ± 1.5 cells/100 μ2 micropillar surface vs. 25.9 ± 3.1 cells/100 μ2 flat substrate, p < 0.0001) This is the first report of trophozoite adhesion to a substratum by a mechanism other than the direct attachment of the ventral adhesive disk, and provides experimental evidence that the ventrolateral flange may play a role in trophozoite adhesion. A hypothesis is presented describing how the adhesive nature of the ventrolateral flange might be involved in normal attachment of G. lamblia trophozoites to a substratum.
Explaining the differences in massive star models from various simulations

The evolution of massive stars is the basis of several astrophysical investigations, from predicting gravitational-wave event rates to studying star-formation and stellar populations in clusters. However, uncertainties in massive star evolution present a significant challenge when accounting for these models’ behaviour in stellar population studies. In this work, we present a comparison between five published sets of stellar models from the BPASS, BoOST, Geneva, MIST and PARSEC simulations at near-solar metallicity. The different sets of stellar models have been computed using slightly different physical inputs in terms of mass-loss rates and internal mixing properties. Moreover, these models also employ various pragmatic methods to overcome the numerical difficulties that arise due to the presence of density inversions in the outer layers of stars more massive than 40 M⊙. These density inversions result from the combination of inefficient convection in the low-density envelopes of massive stars and the excess of radiative luminosity to the Eddington luminosity. We find that the ionizing radiation released by the stellar populations can change by up to 18 per cent, the maximum radial expansion of a star can differ between 100–1600 R⊙, and the mass of the stellar remnant can vary up to 20 M⊙ between the five sets of simulations. We conclude that any attempts to explain observations that rely on the use of models of stars more massive than 40 M⊙ should be made with caution.
The Mortality Penalty of Incarceration

There is a growing body of research on the effects of incarceration on health, though there are few studies in the sociological literature of the association between incarceration and premature mortality. This study examined the risk of male premature mortality associated with incarceration. Data came from the Izhevsk (Russia) Family Study, a large-scale population-based case-control design. Cases (n = 1,750) were male deaths aged 25 to 54 in Izhevsk between October 2003 and October 2005. Controls (n = 1,750) were selected at random from a city population register. The key independent variable was lifetime prevalence of incarceration. I used logistic regression to estimate mortality odds ratios, controlling for age, hazardous drinking, smoking status, marital status, and education. Seventeen percent of cases and 5 percent of controls had been incarcerated. Men who had been incarcerated were more than twice as likely as those who had not to experience premature mortality (odds ratio = 2.2, 95 percent confidence interval: 1.6–3.0). Relative to cases with no prior incarceration, cases who had been incarcerated were more likely to die from infectious diseases, respiratory diseases, non–alcohol-related accidental poisonings, and homicide. Taken together with other recent research, these results from a rigorous case-control design reveal not only that incarceration has durable effects on illness, but that its consequences extend to a greater risk of early death. I draw on the sociology of health literature on exposure, stress, and social integration to speculate about the reasons for this mortality penalty of incarceration.