Miracle-dz/UniFAR-FTUs huggingface dataset:
Endoscopic resection of adenoma‐like mass in chronic ulcerative colitis using a combined endoscopic mucosal resection and cap assisted submucosal dissection technique

Background: Resection of an adenoma‐like mass (ALM) in chronic ulcerative colitis (CUC) complicated by mucosal fibrosis has historically not been technically feasible. Endoscopic submucosal dissection techniques may now provide a therapeutic tool enabling the division of submucosal fibrotic scarring, hence enabling endoluminal resection for the first time in this select patient group. The aim was prospective evaluation of endoscopic submucosal dissection‐assisted (ESD) resection of flat, sessile, and lateral spreading tumors in CUC complicated by submucosal desmoplasis. Clinical endpoints were postresection recurrence rates, R0 resection status, and complications. Methods: ESD‐assisted endoscopic mucosal resection (EMR) using the Olympus KD‐630L insulation‐tipped knife was performed on selected lesions. Results: Sixty‐nine patients met inclusion criteria, of which 2 were excluded due to follow‐up default. En bloc resection was performed in 52/67 (78%) cases with 15/67 (7%) requiring a piecemeal approach. R0 resection was achieved in 49/52 (94%) of lesions undergoing en bloc resection (perforation rate 2/67 [3%]). Bleeding complications occurred in 7/67 (10%) of cases. No metachronous circumscribed intraepithelial neoplastic lesions or cancer was detected at follow‐up. At a median of 18 months follow‐up, overall cure rates for the ESD‐assisted EMR cohort was 66/67 (98%). Conclusions: We have shown for the first time that endoscopic resection of ALM even in the presence of complicating mucosal fibrosis is technically achievable using a combined ESD‐assisted EMR technique. In an appropriately selected cohort, this technique may provide a technically feasible and clinically acceptable therapy where otherwise colectomy would be required.
A 0dB crossover based on novel composite right/left handed transmission line

In this paper, a novel OdB crossover centering at 1.8GHz is proposed based on the initially proposed composite right/left handed transmission line (CRLH TL). The CRLH TL synthesized by Wunderlich-shaped dentiform capacitor and meandered-line short-circuited stub inductor (SSI) can be considered as a complete alternative to its conventional counterpart formed by interdigital capacitor and SSI. Extracted circuit parameters based on the constitutive electromagnetic parameters indicate that the left handed (LH) capacitor has increased obviously by using fractal concept. The enhanced LH capacitor is the key factor of the resultant lower resonance of CRLH cell which enables the design of an electrically smaller particle. The particular merit of the novel CRLH TL suggests potential application in compact microwave devices design. To illustrate possible application, a crossover is designed. Numerical results indicate that the crossover has received 46.2% size reduction and simultaneously exhibits comparable performance relative to its conventional counterpart.
End-to-End Anastomosis Using Improved Stent Graft

In order to overcome the problems of suture method in vessel anastomosis, many non-suture methods have been designed; however, they still have their limits and drawbacks in limited in smaller vascular and destruction on vessel wall. The purpose of this study is to investigate the direct sutureless end-to-end anastomosis by using stent graft. An ex-vivo experiment was conducted to evaluate the oversizing effect on water leakage.
Regulation of Lysosomal Degradation by CA2+And CA2+-Binding Proteins

La macroautofagia y la endocitosis son dos procesos catabolicos conservados evolutivamente en los que, mediante un trafico vesicular, se degrada el material secuestrado, cuyo origen es intra- y extracelular, respectivamente. Ambos procesos comienzan de manera diferente: mediante la formacion de un nuevo organulo, el autofagosoma, que secuestra material citoplasmico (macroautofagia), o mediante la internalizacion de material extracelular y de algunos componentes de la membrana plasmatica a traves de vesiculas endociticas (endocitosis). Sin embargo, los dos terminan en el mismo compartimiento: el lisosoma. En un analisis proteomico de membranas lisosomales, purificadas a partir de fibroblastos de raton, identificamos tres proteinas, que se unen a fosfolipidos de una manera dependiente de calcio, y cuyos niveles en la membrana lisosomal aumentaban en ausencia de aminoacidos, una condicion que activa la macroautofagia. Basandonos en esos resultados iniciales, y teniendo en cuenta que el calcio es un segundo mensajero muy importante, decidimos: en primer lugar, abordar el papel del calcio en la activacion de la autofagia producida por el ayuno de aminoacidos, y, en segundo lugar, investigar el papel de esas tres proteinas en el mecanismo autofagico. Como resultado de estos estudios, describimos en primer lugar una nueva via de senalizacion dependiente de calcio que activa la formacion de autofagosomas por los aminoacidos. Concretamente, hemos encontrado que el ayuno de aminoacidos esenciales produce un aumento en el calcio citosolico, procedente tanto del medio extracelular como de almacenes intracelulares. Como consecuencia de esto, la calmodulina quinasa quinasa- s activa a AMPK y a mTORC1. En la ultima etapa de esta via, ULK1, una quinasa responsable de la iniciacion de la autofagia, se activa para contribuir a la formacion de los autofagosomas. Las tres proteinas identificadas en el estudio proteomico y cuyos niveles en las membranas lisosomales aumentan en ausencia de aminoacidos son la anexina A1, la anexina A5 y la copina 1. Empleando metodos bioquimicos y de inmunofluorescencia observamos que el ayuno de aminoacidos causa la translocacion de la anexina A5 desde el complejo de Golgi hasta las membranas lisosomales, donde tambien se acumulan la anexina A1 y la copina 1. Asimismo, demostramos por sobre-expresion y silenciamiento de esas tres proteinas, que las tres inducen la fusion de autofagosomas con lisosomas y que la copina 1, y en menor medida la anexina A1, aumentan el efecto individual de la anexina A5. Finalmente, la anexina A5 inhibe la endocitosis mientras que copina 1 la induce. En resumen, nuestros resultados ponen de manifiesto que la activacion de la formacion de autofagosomas por el ayuno de aminoacidos es debida, al menos en parte, a una via de senalizacion dependiente de Ca2+ y que esta condicion tambien conlleva la aceleracion de la maduracion de los autofagosomas a autolisosomas a traves de proteinas que unen el Ca2+ como las anexinas A1 y A5 y la copina 1.
Precision electrical measurements to characterize electrostatic MEMS based energy harvesters

This paper presents results of work undertaken for exploring the use of precision electrical measurements to characterize the mechanical properties of Micro-Electro-Mechanical Systems (MEMS) based energy harvesters. Indeed, it is possible to determine the mechanical resonant frequency and the damping factor of MEMS structures by using the mechanical-electrical coupling in MEMS variable capacitor. An electrical low-pass filter can be used to model the mechanical system whose properties are then measured by determining the filter parameters as the cut-off frequency. Resonant frequencies ranging from 0.8 kHz to 5 kHz of electrostatic MEMS-based harvesters have been measured by this technique with an uncertainty as low as one part in 103 in a good agreement with measurements carried out by using Deep Level Transient Spectroscopy system.
O USO DE MODELOS BASEADOS EM VALOR NO BRASIL

O uso de modelos baseados em valor para fins de avaliacao de desempenho gerencial tende a crescer cada vez mais no Brasil, haja vista o que vem acontecendo nos paises mais desenvolvidos. Neste trabalho, desenvolvemos uma pesquisa sobre o uso efetivo ou intencao de uso desses modelos junto a uma amostra de executivos financeiros de empresas predominantemente de grande porte. Os resultados sugerem que ja ha um bom conhecimento de tais modelos por parte dos executivos financeiros das empresas, sendo grande o potencial de uso, embora sejam reconhecidas algumas dificuldades operacionais para uma bem sucedida implantacao como, por exemplo, a falta de um bom sistema de informacoes contabeis e financeiras. Os principais beneficios advindos do uso desses modelos sao: adocao de uma visao de longo prazo e a consideracao explicita do custo do capital empregado.
ACEII, a Novel Transcriptional Activator Involved in Regulation of Cellulase and Xylanase Genes of Trichoderma reesei *

A novel yeast-based method to isolate transcriptional activators was applied to clone regulators binding to the cellulase promoter cbh1 of the filamentous fungusTrichoderma reesei (Hypocrea jecorina). This led to the isolation of the cellulase activator ace2encoding for a protein belonging to the class of zinc binuclear cluster proteins found exclusively in fungi. The DNA-binding domain of ACEII was expressed as a glutathione S-transferase fusion protein in Escherichia coli, and ACEII was shown to bindin vitro to the 5′-GGCTAATAA site present in thecbh1 promoter. This site also contains the proposed binding sequence of the xylanase activator XlnR of Aspergillus niger. Mutation of the GGC triplet abolished ACEII binding. The function of ACEII was studied by analyzing the effects oface2 deletion in the hypercellulolytic T. reesei strain ALKO2221. Deletion of the ace2 gene led to lowered induction kinetics of mRNAs encoding the major cellulases cellobiohydrolases I and II and endoglucanases I and II and to 30–70% reduced cellulase activity when the fungus was grown on medium containing Solka floc cellulose. The expression level of the gene encoding xylanase was also affected. ace2 deletion led to lowered xyn2 expression in cellulose-induced cultivation. Cellulase induction by sophorose was not affected byace2 deletion.
Short-Sighted Routing, or When Less is More

Due to the high costs of wide area links, traffic engineering is frequently used to optimize wide area networks' performance. In recent years, architectures based on software defined networking approaches are being proposed as better ways of implementing network control and management. However, network optimization requires timely acquisition of statistics on network traffic demands by SDN controllers, as well as timely reconfiguration of network paths. Both goals may only be achieved with a scalable control plane. In this article, we present an approach meant to trade complexity and scalability of the control plane for routing optimality. Our experiments suggest that the performance of provider networks is nearly optimal, even when load balancing parameters have been computed using a slightly outdated vision of traffic demands. We named this approach short-sighted routing (SSR). Our results also show that performance optimality in many provider networks that use load balancing over several paths is not affected in a significant way by relaxing the timeliness of network traffic demands acquisition and the corresponding load balancing reconfiguration. This has allowed us to conclude that dynamic centralized network optimization and management, in accordance with an SDN approach, is also quite realistic in service provider networks.
Angle-Tree: a new index structure for high-dimensional point data

Many multi-dimensional index structures, such as R-Tree, R*-Tree, X-Tree, SS-Tree, VA-File, etc. have been proposed to support similarity search with l1, l2 or l(infinity ) distance as similarity measure. But they can not support such similarity search with cosine as the similarity measure. In this paper, an index structure Angle-Tree is introduced to resolve the problem. It first projects all the high dimensional points onto the unit hyper-spherical surface, i.e. normalize each original vector in the database into a unit one. Then an index structure similar to R-Tree is built for those projected points. The experimental results show that the Angle-Tree can decrease the cost of disk I/O and support fast similarity search.
Depth Inpainting with Tensor Voting using Local Geometry

Range images captured from range scanning devices or reconstructed form optical cameras often suffer from missing regions due to occlusions, reflectivity, limited scanning area, sensor imperfections etc. In this paper, we propose a fast and simple algorithm for range map inpainting using Tensor Voting (TV) framework. From a single range image, we gather and analyze geometric information so as to estimate missing depth values. To deal with large missing regions, TV-based segmentation is initially employed as a cue for a region filling. Subsequently, we use 3D tensor voting for estimating different plane equations and pass depth estimates from all possible local planes that pass through a missing region. A final pass of tensor voting is performed to choose the best depth estimate for each point in the missing region. We demonstrate the effectiveness of our approach on synthetic as well as real data.
Ideas for a Study "On the Imagination of Tone"

A guiding principle that extends throughout my music-theoretic and music-aesthetic work from the time of my dissertation (Musikalische Logik, Leipzig, C. F. Kahnt, 1873)1 is that music listening is not merely a passive processing of sound effects in the ear but, on the contrary, a highly developed manifestation of the logical functions of the human intellect. Without being absolutely clear myself of that which I really sought and to which I aspired, I have gradually developed a kind of musical grammar in my new system of notation for harmony ("Skizze einer neuen Methode der Harmonielehre," [Leipzig] 1880) in its various stages of development up to the formulation of the "Lehre von den tonalen Funktionen der Harmonie" ("Vereinfachte Harmonielehre," 1893), and likewise in the labelling of rhythmic elements in music (phrase markings) from the very first articles to raise the question in "Musikalisches Wochenblatt" (1882)2 up to the formulation of a "System der musikalischen Rhythmik und Metrik" (1904). 3 In the harmonic concepts tonic, dominant, subdominant, and the rhythmic concepts "heavy and light beats," "heavy and light measures," "antecedent, consequent," etc., this grammar points to the
Plasma Malondialdehyde Levels in Children on 12-Hour Cyclic Parenteral Nutrition: Are There Health Risks?

In children undergoing total parenteral nutrition (PN), lipids provide a key source of calories preventing or correcting energy deficits and improving outcomes. However, some of these lipids may undergo oxidation leading to the formation of malondialdehyde (MDA), a cytotoxic byproduct found in these patients. This paper aims to describe a sensitive method for detecting MDA and discuss its role in certain diseases commonly found in children on regular PN. To quantify MDA levels in children benefitting from long-term cyclic PN, a reliable and sensitive high-performance liquid chromatographic method based on a 1-step derivatization/extraction procedure analysis with ultraviolet determination at 305 nm wavelength was achieved. In control children without PN, MDA levels were on average 3.30 ± 0.08 μM. However, in children nourished intravenously by fat emulsion for a long time, in which liver problems have been identified, the circulating concentrations of MDA ranged widely at both the start and the end of a session, 3- to 10-fold, respectively, in comparison with the levels measured in controls. This finding indicates that PN administrated long term raises plasma MDA levels, indicating chronic exposure and therefore a possible health risk, particularly liver damage. This preliminary study using a limited number of patients and controls showed that children undergoing long-term PN are strongly exposed to MDA, which must be considered as a potent toxic compound rather than a simple marker of lipid peroxidation.
What is Burkitt's lymphoma and when is it endemic?

To the Editor: Denis Burkitt first published an account of the tumor that bears his name in 1958. [1][1] In the following years, there was considerable confusion concerning the nature of the tumor, its relationship to other lymphomas, and whether it occurred outside Africa. To clarify this matter,
Mutational Analysis of the Ricinus Lectin B-chains

Ricin B-chain (RTB) is a galactose-specific lectin that folds into two globular domains, each of which binds a single galactoside. The two binding sites are structurally similar and both contain a conserved tripeptide kink and an aromatic residue that comprises a sugar-binding platform. Whereas the critical RTB residues implicated in lectin activity are conserved in domain 1 of Ricinus communis agglutinin (RCA) B-chain, the sugar platform aromatic residue Tyr-248 present in domain 2 of RTB is replaced by His in RCA B-chain. In this study, key residues in the vicinity of the binding sites of the Ricinus lectin B-chains were altered by site-directed mutagenesis. The recombinant B-chains were produced in Xenopus oocytes in soluble, stable, and core-glycosylated forms. Both sites of RCA B-chain must be simultaneously modified in order to abolish lectin activity, indicating the presence of two independent, functional binding sites/molecule. Activity associated with the domain 2 site of RCA B-chain is abrogated by the conversion of Trp-258 to Ser. Moreover, the domain 2 site appears responsible for a weak binding interaction of recombinant RCA B-chain with GalNAc, not observed with native tetrameric RCA. Finally, the introduction of His at position 248 of RTB severely disrupts but does not abolish GalNAc binding.
Underwater 3-D Scene Reconstruction Using Kinect v2 Based on Physical Models for Refraction and Time of Flight Correction

Commercial RGB-D cameras provide the possibility of fast, accurate, and cost-effective 3-D scanning solution in a single package. These economical depth cameras provide several advantages over conventional depth sensors, such as sonars and lidars, in specific usage scenarios. In this paper, we analyze the performance of Kinect v2 time-of-flight camera while operating fully submerged underwater in a customized waterproof housing. Camera calibration has been performed for Kinect’s RGB and NIR cameras, and the effect of calibration on the generated 3-D mesh is discussed in detail. To overcome the effect of refraction of light due to the sensor housing and water, we propose a time-of-flight correction method and a fast, accurate and intuitive refraction correction method that can be applied to the acquired depth images, during 3-D mesh generation. Experimental results show that the Kinect v2 can acquire point cloud data up to 650 mm. The reconstruction results have been analyzed qualitatively and quantitatively, and confirm that the 3-D reconstruction of submerged objects at small distances is possible without the requirement of any external NIR light source. The proposed algorithms successfully generated 3-D mesh with a mean error of ±6 mm at a frame rate of nearly 10 fps. We acquired a large data set of RGB, IR and depth data from a submerged Kinect v2. The data set covers a large variety of objects scanned underwater and is publicly available for further use, along with the Kinect waterproof housing design and correction filter codes. The research is aimed toward small-scale research activities and economical solution for 3-D scanning underwater. Applications such as coral reef mapping and underwater SLAM in shallow waters for ROV’s can be a viable application area that can benefit from results achieved.
Guidance on Management of Asymptomatic Neonates Born to Women With Active Genital Herpes Lesions

Herpes simplex virus (HSV) infection of the neonate is uncommon, but genital herpes infections in adults are very common. Thus, although treating an infant with neonatal herpes is a relatively rare occurrence, managing infants potentially exposed to HSV at the time of delivery occurs more frequently. The risk of transmitting HSV to an infant during delivery is determined in part by the mother’s previous immunity to HSV. Women with primary genital HSV infections who are shedding HSV at delivery are 10 to 30 times more likely to transmit the virus to their newborn infants than are women with recurrent HSV infection who are shedding virus at delivery. With the availability of commercial serological tests that reliably can distinguish type-specific HSV antibodies, it is now possible to determine the type of maternal infection and, thus, further refine management of infants delivered to women who have active genital HSV lesions. The management algorithm presented herein uses both serological and virological studies to determine the risk of HSV transmission to the neonate who is delivered to a mother with active herpetic genital lesions and tailors management accordingly. The algorithm does not address the approach to asymptomatic neonates delivered to women with a history of genital herpes but no active lesions at delivery.
Predictors of Polypharmacy and Off-Label Prescribing of Psychotropic Medications: A National Survey of Child and Adolescent Psychiatrists

We employed a national survey of child psychiatrists to examine typical prescribing practices for children with anxiety, depression, and disruptive behavior disorders. We examined the extent to which polypharmacy and off-label prescribing occur in routine practice and the degree to which child characteristics, child psychiatrist characteristics, and medication availability may influence these prescribing practices. We found that child psychiatrists most often prescribed medications that were on-label according to U.S. Food and Drug Administration (FDA) guidelines, and that they were progressively less likely to choose medications with partial approval (i.e., medications having pediatric approval but not for the patient’s age or problem type), and then medications with no pediatric approval. We also found that prescribing multiple concomitant medications was the norm. We employed best subsets regression to determine the best theoretically relevant predictors to explain polypharmacy and off-label prescribing and found that the best fitting model only included number of child diagnoses. These findings suggest that comorbidity is an important issue in the pharmacotherapy of children with mental health disorders and one that must be addressed in future clinical trials. (Journal of Psychiatric Practice 2014;20:438–447)
Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: histochemical, autoradiographic, in vivo, and in vitro studies.

A high density of galanin binding sites was found by using 125I-labeled galanin, iodinated by chloramine-T, followed by autoradiography in the ventral, but not in the dorsal, hippocampus of the rat. Lesions of the fimbria and of the septum caused disappearance of a major population of these binding sites, suggesting that a large proportion of them is localized on cholinergic nerve terminals of septal afferents. As a functional correlate to these putative galanin receptor sites, it was shown, both in vivo and in vitro, that galanin, in a concentration-dependent manner, inhibited the evoked release of acetylcholine in the ventral, but not in the dorsal, hippocampus. Intracerebroventricularly applied galanin (10 micrograms/15 microliters) fully inhibited the scopolamine (0.5 mg/kg, s.c.)-stimulated release of acetylcholine in the ventral, but not in the dorsal, hippocampus, as measured by microdialysis technique. In vitro, galanin inhibited the 25 mM K+-evoked release of [3H]acetylcholine from slices of the ventral hippocampus, with an IC50 value of approximately 50 nM. These results are discussed with respect to the colocalization of galanin- and choline acetyltransferase-like immunoreactivity in septal somata projecting to the hippocampus.