Miracle-dz/UniFAR-FTUs huggingface dataset:
Mapping geological structures in bedrock via large-scale direct current resistivity and time-domain induced polarization tomography

An investigation of geological conditions is always a key point for planning infrastructure constructions. Bedrock surface and rock quality must be estimated carefully in the designing process of infrastructures. A large direct-current resistivity and time-domain induced-polarization survey has been performed in Dalby, Lund Municipality, southern Sweden, with the aim of mapping lithological variations in bedrock. The geology at the site is characterised by Precambrian granitic gneisses and amphibolites, which are intensely deformed, fractured, and partly weathered. In addition, there are northwest-trending Permian dolerite dykes that are less deformed. Four 2D direct-current resistivity and time-domain induced-polarization profiles of about 1-km length have been carefully pre-processed to retrieve time-domain induced polarization responses and inverted to obtain the direct-current resistivity distribution of the subsoil and the phase of the complex conductivity using a constant-phase angle model. The joint interpretation of electrical resistivity and induced-polarization models leads to a better understanding of complex three-dimensional subsoil geometries. The results have been validated by lithological descriptions from several drillings. In addition, direct-current resistivity and time-domain induced-polarization logging has been carried out in two different boreholes, showing a good match with the results of the surface direct-current resistivity and time-domain induced-polarization profiles. The direct-current resistivity and time-domain induced-polarization methodology proved to be a suitable technique for extensively mapping weathered zones with poor geotechnical characteristics and tectonic structures, which can lead to severe problems for infrastructure construction and/or constitute risk zones for aquifer contamination.
CURCUMIN AND ITS NANOFORMULATIONS: A COMPREHENSIVE OVERVIEW FOR THE MANAGEMENT OF DIABETES COMPLICATIONS

Diabetes is a chronic metabolic disorder that has reached pandemic proportions, and which is a major cause of morbidity and mortality worldwide. Type 1 diabetes is an autoimmune disorder resulting in almost complete destruction (98%) of insulin secreting beta cells in the pancreas, while type 2 diabetes is considered to be a disease of protein misfolding where, in addition to the average 65% loss of beta cell mass, insulin resistance occurs in target organs. Diabetic complications, such as retinopathy, nephropathy, neuropathy and cardiovascular disease, are common and majorly impact a patient’s quality of life. Curcumin is the yellowish polyphenolic component of the dietary spice turmeric, which is the rhizomes of Curcuma longa, a herb in the ginger family (Zingiberaceae). Curcumin effectively reduces glycemia and hyperlipidemia but also has beneficial effects on diabetic complications due to its anti-inflammatory and antioxidant properties, in a relatively inexpensive and safe manner. New improved methods of delivering curcumin are being developed including nanoparticles and lipid/liposome formulations that increases its absorption and bioavailability as curcumin is poorly absorbed by the digestive system and undergoes glucuronidation and excretion rather than being released into the serum and systemically distributed. Development and refinement of these technologies will enable cell-directed targeting of curcumin and improved therapeutic outcome. The current review focuses on the antidiabetic efficacy of curcumin and nano-drug delivery approaches in attenuating diabetes and its complications.
Performance Analysis and Comparison Between Robust Adaptive Beamforming

With the ever-growing needs of a high quality of wireless communication services, the field of multiple-antenna systems, which is often called Multiple-Input Multiple-Output (MIMO) systems, has evolved rapidly. In principle, multiple-antenna techniques can fully exploit the spatial domain information to enhance wireless communication quality, so have constituted the key technologies for modern wireless communications. Adaptive beamforming, which can be interpreted as a processor in conjunction with an array of antennas to provide an adaptive form of spatial filtering, is effectively utilized to improve the Signal Interference Noise Ratio (SINR) or suppress spatial noise and interference in a multiuser scenario. However, due to the array steering vector errors, small-sample errors and so on, its performance will suffer from a substantial degradation in practical engineering applications. In this paper, Norm Constraint Robust Capon Beamforming (NCRB) and Worst-Case Performance Optimization Robust Beamforming (WCRB) are respectively formulated as a standard SOCP form, and their performances are compared and analyzed in detail. Finally, computer simulations show the algorithms’ excellent performance for Signal Of Interest (SOI) power estimation and output SINR (Signal Interference Noise Ratio) as compared with the standard adaptive beamforming via a number of numerical examples.
Types behind the mirror : a proposal for partial ML type reconstruction at run-time.

Polymorphic parametric languages, statically typed, a la ML, do not need to keep types inside their values during runtime to have a safe execution. Nevertheless this type information gives new possibilities for debugging, allows to extend the language to manipulate types as values. It can be stored either in stack or in heap. To manage the additional type information, we propose in this paper to divide the heap in a value space and a mirror space. The first space is used to store values, the second one is used to store type information and garbage collecting. We describe a new Stop & Copy GC algorithm handling the divided heap with low memory cost. We finally give proposals for partially rebuilding types from informations stored in the mirror space.
Advances in understanding the genetics of syndromes involving congenital upper limb anomalies

Congenital upper limb anomalies (CULA) are a common birth defect and a significant portion of complicated syndromic anomalies have upper limb involvement. Mostly the mortality of babies with CULA can be attributed to associated anomalies. The cause of the majority of syndromic CULA was unknown until recently. Advances in genetic and genomic technologies have unraveled the genetic basis of many syndromes-associated CULA, while at the same time highlighting the extreme heterogeneity in CULA genetics. Discoveries regarding biological pathways and syndromic CULA provide insights into the limb development and bring a better understanding of the pathogenesis of CULA. The aim of this review is to provide an overview of the genetic basis of syndromic CULA and discuss the role of biological pathways in syndromic CULA.
TECHNOLOGICAL FORECASTING: LIPOSOMES AS DRUG DELIVERY VEHICLES WITH THERAPEUTIC POTENTIAL

A aplicacao de lipossomas para a administracao controlada de farmacos tem tido um grande impacto em muitas areas biomedicas. Verificou-se que eles sao beneficos para a estabilizacao de compostos terapeuticos, superacao de obstaculos a absorcao celular e de tecidos e melhoria da biodistribuicao de compostos para locais-alvo in vivo. Essa prospeccao teve como objetivo analisar as patentes que tratam da utilizacao de lipossomas como veiculos de drug delivery . A busca foi realizada nos bancos de dados do INPI e do EPO. As patentes encontradas foram analisadas quanto a quantidade, datas de publicacao, pais de origem dos depositantes e dos inventores, pais onde foram depositadas e Classificacao Internacional de Patentes (IPC). Apesar de ser uma area em ascensao e despontar com uma tendencia, nao ha depositos nesta area no Brasil, que sofre de problemas sistematicos relacionado a producao de patentes.
Transforaminal Nerve Roots Steroid Injections Versus Pulsed Radiofrequency Application For Treatment of Chronic Low Back Pain

Objectives: This study aims to Compare the Effectivenesses of transforaminal epidural steroid injection (TFESI) for the Nerve Roots Steroid Injections Versus Pulsed Radiofrequency Application For Treatment of Chronic Low Back Pain Patients and methods: The study, which was conducted between September 2013 and September 2016, included 40 patients with low back pain (13 males, 27 females; median age 45 years; [min. 22 max. 88 years]). All injections were applied under Carm fluoroscopy guidance, using a mix of methyprdnisone and macain. The valuation parameters are pain evaluation pre and post the procedure (2hrs after the procedure , 1st week ,after one month and after 3 months from the procedure) . the pain evaluation by visual analoge scale (0-10) and low back pain questionare also consumption of analgesic drugs is compared pre and post procedure. Reporting of possible complications Results: As regard pain scores for both groups group there was significant decrease in VAS score in both groups from the preprocedure score (P-value<0.001). Patients in group 1 had less VAS scores in comparison for group 2 (P-value=0.005). also There was significant decrease in LBP score in both groups from the preprocedure score (Pvalue<0.001). Patients in group 1 had less LBP score in comparison for group 2 (Pvalue<0.001). Conclusion: In this study, we aimed to present the effectiveness 0f Transforaminal Nerve Roots Steroid Injections Versus Pulsed Radiofrequency Application For Treatment of Chronic Low Back Pain. We found that there was significant decrease in VAS score in both groups from the pre procedure score. Patients in TFESI group had less VAS and low back pain scores in comparison for PRF group , and application of PRF is more safe than steroid injection
Massively multilingual accessible audioguides via cell phones

Bidaide1 is a web service that allows the visitors of a museum, route or building to read or listen to explanations relative to the visited place on their own mobile and in their own language. The visitor can access the explanations in various ways: by scanning some QR codes located in the place, by GPS positioning (in outdoor routes), or by automatic Bluetooth proximity activation. This makes it accessible for people with reduced or null vision. On the other hand, this platform also offers to the manager of the visited site the most advanced language resources to create the texts and audios of the explanations in many languages.
Meridian Acupuncture in Stroke Rehabilitation: A literature review

Abstract Rehabilitation therapy has an important role in restoring bodily functions comprehensively due to stroke which aims to restore function so as to reduce disability. One therapy that nurses can do is to use acupuncture meridian points. Acupuncture is considered to play a leading role in the treatment of symptoms related to stroke. This literature review aims to analyze the benefits of the acupuncture points in stroke rehabilitation. The research method used by the author is a literature review using several databases namely Pubmed, Cochrane Library, EbscoHost, Proquest and Google Scholar from 2008 to 2018. An article that discusses rehabilitation of stroke patients using acupuncture meridian points is used as a medium of rehabilitation. The literature search results show that the rehabilitation of acupuncture meridian points provides the benefits of recovery of stroke symptoms such as hemiparese, dyspagia, dementia, and reduced volume and infarction including neurological deficits so as to improve the quality of life for stroke patients. Keywords: stroke, rehabilitation, quality of life, acupuncture, meridians
Management and cause analysis of platelet transfusion refractoriness

Platelet transfusion refractoriness (PTR) can be defined as the less increment of platelet count than expected after platelets transfusion, which is a challenging and expensive problem often observed in platelet-transfusiondependent patients. Although PTR occurs most frequently due to non-immune causes, a significant minority is still caused by immune factors. The most important factor in immune dependent PTR is alloimmunization against Class I human leukocyte antigens (HLAs) or human platelet antigens (HPAs). The compatible platelets can be provided to immune-mediated patients using platelet crossmatching, HLA matching, and antibody specificity testing. These measures-aimed to eliminate donor-specific HLA antibodies will lead to the improved clinical management of PTR patients, caused by severe alloimmunization.
Change in Australian Vitamin A Intakes over Time

ABSTRACT Background The mean intake of vitamin A of Australians aged 2 y and older was 300 µg retinol equivalents lower in the 2011–2012 national nutrition survey than in 1995 and decreases preponderated in adults rather than young children. Objective This aim of this study was to identify the foods associated with this change and to examine how the method used to adjust for within-person variability affects the estimated prevalence of inadequate intakes in both surveys. Methods Foods contributing to vitamin A intake were calculated from the first day of data. The prevalence of inadequate intakes was calculated using a 2-d average, the Iowa State University method, and the National Cancer Institute (NCI) method and either taken from the published reports or calculated using Food Standards Australia New Zealand's in-house software. Results In adults, lower consumption of liver, yellow fat spreads, milk products, and carrots and similar root vegetables accounted for most of the change in intake. Vitamin A intake data were less right-skewed in 2011–2012 than in 1995. The prevalence of inadequate vitamin A intake depended on the adjustment method chosen: for example, in 2011–2012 it ranged between 3% and 55% in men aged 19–30 y. The NCI method prevalence (21% for this group) is taken as the preferred estimate of inadequacy because the method adjusts around the mean and accounts for several other sources of variance. However, the NCI method could not be used to analyze the 1995 survey. Conclusions The lower vitamin A intake in Australia was related to changes in retinol intake rather than carotenoid intake and to lower consumption of several different types of food. The estimated prevalence of inadequate intake depends on the statistical method chosen for analysis. A direct measure of vitamin A status is needed to allow conclusions about the implications of the decreasing intake of this vitamin.
Treatment of diaphyseal fractures of tibia with intramedullary interlocking nail

<p class="abstract"><strong>Background:</strong> The tibia, or shinbone, is the most commonly fractured long bone in the body. A tibial shaft fracture occurs along the length of the bone, below the knee and above the ankle. It typically takes a major force to cause this type of broken leg. Motor vehicle collisions, for example, are a common cause of tibial shaft fractures. In many tibia fractures, the smaller bone in the lower leg (fibula) is broken as well. The objective was to study fracture healing and union rates with closed intra-medullary interlocking nailing. </p><p class="abstract"><strong>Methods:</strong> Patients of both sexes belonging to adult age group presenting with fracture tibia to Orthopedic Department, Vydehi Institute of Medical Sciences, of are admitted from January 2015 to December 2015. <strong></strong></p><p class="abstract"><strong>Results:</strong> In the present study maximum number of patients belongs to 18 to 27 years age group (18 cases) followed by 28 to 37 years age group (15 cases), maximum number of patients sustained tibia fracture due to RTA (38 cases) followed by fall (12 cases), maximum number of patients sustained simple tibia fracture (32 cases), followed by type 2 compound tibia fracture (13 cases) and 36 patients had excellent functional results and 8 patients had good functional outcome, while only 4 patients had fair functional outcome. </p><p class="abstract"><strong>Conclusions:</strong> IM rods are secured within the bone by screws both above and below the fracture. The metal screws and the rod can be removed if they cause problems, but can also be left in place for life. Tibial rodding provides excellent fixation and alignment of the bones. </p>
Effect of ‘lifestyle stigma’ on public support for NHS-provisioned pre-exposure prophylaxis (PrEP) and preventative interventions for HPV and type 2 diabetes: a nationwide UK survey

Objectives This study examines how the perceived role of poor lifestyle and irresponsible behaviour in contracting HIV, human papilloma virus (HPV) and diabetes affects public support for government-provisioned prevention efforts in Britain. It assesses whether public attitudes on healthcare spending are broadly sensitive to ‘lifestyle stigmas’. Methods We conducted an online survey of 738 respondents in Britain and embedded three separate survey experiments to measure support for government-provisioned interventions for HIV, HPV and type 2 diabetes. In each experiment, we manipulated language used to describe the extent to which the diseases are caused by lifestyle choices. Most respondents participated in all three experiments, but assignment was randomised within each condition. Analysis compared support among respondents exposed to ‘lifestyle’ treatment (information emphasising the disease’s lifestyle causes) versus control treatment. We estimated three separate t-tests in which support for government provision of interventions is the dependent variable. Results Support for government-provisioned prevention was high for all three diseases. There was no statistical difference between treatment and control conditions for HIV (treatment mean=3.73, control mean=3.86, p=0.38). But in both HPV (treatment mean=3.96, control mean=4.43, p<0.01) and type 2 diabetes (treatment mean=3.53, control mean=4.03, p<0.01) experiments, support for government-provisioned interventions was significantly lower under lifestyle treatment conditions. Conclusions Public opinion on healthcare expenditures in Britain is unexpected and uneven. Consistent participant support for pre-exposure prophylaxis (PrEP) shows public attitudes are not always sensitive to lifestyle stigmas—but for other diseases, perceived relationships between individual behaviour and poor health can still shape public opinion about health expenditures. Policymakers and practitioners should remain attentive to how health problems are framed and discussed to ensure broad public support, and take advantage of policy windows like with PrEP as they may close.
A Binary-Feature-Based Object Recognition Accelerator With 22 M-Vector/s Throughput and 0.68 G-Vector/J Energy-Efficiency for Full-HD Resolution

Considering that the binary-feature-based approximate nearest neighbor (ANN) search technique has not been fully exploited to date, a multisegment binary feature-based hierarchical clustering tree model is proposed to achieve fast binary feature matching (FM). In addition, the multisegment vocabulary forest, is developed for the ease of hardware-oriented implementation. During the ANN searching process, the corresponding leaf nodes of each segment of the query feature are returned simultaneously to improve processing speed and accuracy. Furthermore, a hierarchical decomposition based on the term frequency-inverse document frequency is used to reduce the run-time search space and total memory footprint for object database storage. Finally, a fine-grained feature-level fully pipelined object recognition accelerator is implemented based on a dedicated design between FM and object scoring. The performance of the proposed object recognition accelerator is evaluated based on TSMC 65 nm CMOS technology. The accelerator achieves 22 M-vec/s and <inline-formula> <tex-math notation="LaTeX">$6.8 \boldsymbol \times 10^{\mathbf {8}}$ </tex-math></inline-formula> vec/J in throughput and energy efficiency for full-HD resolution, respectively; these results represent a <inline-formula> <tex-math notation="LaTeX">$10.6\boldsymbol \times $ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$9\boldsymbol \times $ </tex-math></inline-formula> improvement, respectively, relative to current state-of-the-art solutions. The average power consumption is 32.6 mW when operating at 200 MHz.
Clinical appearance of vascular compromise after filler injection

Background: Although filler injections are established as safe and effective for facial rejuvenation, they have been associated with adverse outcomes. Vascular compromise is one of the most severe complications arising from facial filler injections, either as inadvertent intra-arterial embolization or vascular compression, which leads to localized skin necrosis or vision loss. Objective: This study aimed to estimate the clinical course and causes of vascular compromise after filler injections by conducting a retrospective analysis. Methods: We retrospectively analyzed 30 patients (28 females; mean age, 35.1 years; age range, 24-45 years) with vascular compromise in the nose after receiving filler injections between June 1, 2010 and June 30, 2015. All the patients began treatment of vascular compromise within 5 days after receiving filler injection. We retrospectively analyzed the patterns of filler necrosis by using medical photographs and records. Results: The pattern of vascular compromise followed the blood vessel distribution. As the vessels are connected to each other, they are difficult to classify clearly. However, they can be divided into lesions on the nasal bridge, nasal tip, nasal ala; lesions including more than 2 subunits; and lesions accompanied by surrounding structures such as the lips. In addition, the pattern and outcome of the lesions differed according to the cause, either arterial embolization or vascular compression. Conclusion: Vascular compromise resulting from filler injection can have serious consequences. As necrosis causes serious problems for both the patient and the physician, the possibility of necrosis must be recognized and prevented in advance, and immediate treatment should be performed when symptoms develop.
In Vivo Ultrasound Molecular Imaging of SDF-1 Expression in a Swine Model of Acute Myocardial Infarction

Background: Stem cell therapy of acute myocardial infarction (AMI) is proving to be a promising approach to repair the injured myocardia. The time window for stem cell transplantation is crucial yet difficult to determine since it produces different therapeutic effects at different times after myocardial infarction. Stromal cell-derived factor-1 (SDF- 1) plays a pivotal role in the mobilization, homing, proliferation, and differentiation of transplanted stem cells. Here, by using ultrasound molecular imaging via targeted microbubbles, we determined the dynamic expression of SDF-1 in a swine model of AMI in vivo. Methods: Twenty-four miniswine were randomly selected for the control group and the AMI model group, which underwent ligation of the left anterior descending coronary artery (LAD). The AMI animals were randomly divided into six experimental groups according to the duration of the myocardial infarction. All animals were subjected to ultrasound molecular imaging through injections with targeted microbubbles (T + T group) or nontargeted control microbubbles (T + C group). The values of the myocardial perfusion parameters (A, β, and A × β) were determined using Q-Lab (Philips ultrasound, version 9.0), and the expression level of SDF-1 was analyzed by real-time polymerase chain reaction (RT-PCR). Results: Our results showed that the expression of SDF-1 gradually increased and peaked at 1 week after AMI. The trend is well reflected by ultrasound molecular imaging in the myocardial perfusion parameters. The A, β, and A × β values correlated with SDF-1 in the T + T group (r = 0.887, 0.892, and 0.942; P < 0.05). Regression equations were established for the relationships of the A, β, and A × β values (X) with SDF-1 (Y): Y = 0.699X − 0.6048, Y = 0.4698X + 0.3282, and Y = 0.0945X + 0.6685, respectively (R 2 = 0.772, 0.7957, and 0.8871; P < 0.05). Conclusions: Our finding demonstrated that ultrasound molecular imaging could be used to evaluate the expression dynamics of SDF-1 after AMI.