Miracle-dz/UniFAR-FTUs huggingface dataset:
A high-stability clock generator for 13.56MHz passive RFID tags

This paper presents a clock generator immune with variation of power supply and temperature. This scheme is implemented in a standard 0.18um CMOS technology. Simulation results show that the deviation of the frequency is less than 0.45% with supply variation of 1V; and the temperature drift is 10ppm/°C in the range of -40C - 120°C. The core area of this design is 0.4 × 0.25 mm2.
Direct vascular effects of HR780, a novel 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitor

1. We have examined the effects of HR780, a novel 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase inhibitor, on porcine endothelial cell (EC) injury induced by xanthine (X)/xanthine oxidase (XO), a source of superoxide anion. Furthermore, the effects of HR780 on platelet‐derived growth factor (PDGF)‐induced migration and fetal calf serum (FCS)‐induced proliferation of rabbit smooth muscle cells (SMC) were investigated.
Fast approach to the design of planar devices and antennas based on elliptical patch metasurfaces

This paper presents an efficient and accurate approach for the analysis of anisotropic metasurfaces (MTSs) consisting of elliptical patches printed over a grounded slab. The formulation resorts to an analytical expression of the currents excited on the elements of the periodic texture to define a reduced spectral MoM procedure with only two basis functions. This procedure can be used to effectively characterize the surface waves supported by the MTS, as needed in the design of planar antennas and transformation optics devices based on modulated MTS.
Advancing foundry technology with scaling and innovations

Being the dedicated IC foundry, TSMC provides a complete portfolio of technologies covering leading-edge technology, specialty technology, and 3D IC system integration technology to fulfill customer product needs in various market segments. While the leading-edge CMOS technology continues to extend Moore's law as a driver for business growth, More-than-Moore specialty technology leverages the logic technology platform with value-added components to enable various functionalities for a wide range of applications. In this paper, the evolution of advanced CMOS technology is reviewed. Challenges in scaling transistor, SRAM and interconnect are discussed. Examples of specialty technology will also be illustrated.
Anti-adhesive strategies in the prevention of infectious disease at mucosal surfaces

Binding of microbial cell surface adhesins to host receptor molecules is a critical early step in microbial infection and pathogenesis. Anti-adhesive strategies aimed at blocking this interaction offer an attractive means of preventing infection at an early stage. The strategy should reduce the likelihood of resistant strains of microorganisms emerging, since those that do not bind will not be subjected to sustained selective pressure, as may occur with antibiotic therapy. Three classes of adhesion-blocking agent have been investigated, namely anti-adhesin antibodies, adhesin analogues and receptor analogues. The effectiveness of a number of these adhesion-blocking compounds has been demonstrated in human and animal models of infection. Direct application to the tooth surface of anti-adhesin monoclonal antibody, or a synthetic peptide adhesion epitope, prevented infection with the oral pathogen, Streptococcus mutans in humans. Intranasal administration of a soluble receptor analogue significantly reduced virus production and symptoms following experimental infection with rhinovirus. Similarly, all three types of anti-adhesion agent protected against a variety of infections at other mucosal surfaces in animal models. A common finding from these studies is the long duration of protection, which cannot be due to persistence of the anti-adhesion agent, but may be the result of competitive exclusion by members of the normal flora at specific mucosal surfaces. Development of these novel antimicrobial agents is particularly timely in view of the increasing concern over the spread of antibiotic resistance.
Quantitative structure‐activity relationship for the photoinduced toxicity of polycyclic aromatic hydrocarbons to the luminescent bacteria Vibrio fischeri

Sunlight can greatly enhance the toxicity of polycyclic aromatic hydrocarbons (PAHs). Photosensitization reactions (e.g., generation of singlet‐state oxygen) and photomodification reactions (e.g., photooxidation of PAHs to more toxic species) are both pathways of photoinduced toxicity of PAHs. Previously, a quantitative structure‐activity relationship (QSAR) was developed for PAHs showing that a photosensitization factor (PSF) and photomodification factor (PMF) can be additively combined to describe photoinduced toxicity. That QSAR model was developed for the photoinduced toxicity of 16 PAHs to the higher plant Lemna gibba. The objective of this study was to apply the QSAR model developed for L. gibba to another organism. The organism chosen was the luminescent marine bacteria Vibrio fischeri. Toxicity data used for the QSAR model were inhibition of luminescence and inhibition of growth of V. fischeri. Both short‐term (15 min) and long‐term (18 h) assays of toxicity were used. Light did not impact on PAH toxicity in the short‐term assay, and thus the QSAR model did not correlate well with these data. Conversely, light greatly enhanced toxicity when the long‐term assay was employed. The PMFs for the PAHs from the L. gibba QSAR showed a moderate correlation to bacterial toxicity in the long‐term assay, whereas the PSFs showed only a weak correlation to toxicity. As was the case for L. gibba, summing the PMF and the PSF resulted in a strong correlation to toxicity that had predictive value. Thus, a QSAR model derived for plants accurately described the toxicity of PAHs to a bacterial species. This indicates that the bipartite mechanism of PAH‐photoinduced toxicity may be applicable to other organisms.
Biological interactions of CYP 2 C 19 genotypes with CYP 3 A 4 * 18 , CYP 3 A 5 * 3 , and MDR 1-3435 in living donor liver transplantation recipients

Background: Polymorphisms in CYP2C19 are related to the metabolic oxidation of drugs to varying degrees. The CYP3A4*18, CYP3A5*3, and MDR1-3435 variant alleles are very important, particularly in tacrolimus metabolism in organ transplant rejection. Aim: The aim of this study is o explore possible interactions among different CYP2C19 genotypes, namely, between homozygous extensive metabolizers (HomEM), heterozygous extensive metabolizers (HetEM), and poor metabolizers (PM), and the CYP3A4*18, CYP3A5*3, and MDR1-3435 variants in living donors and patients who received a living donor liver transplant (LDLT). Methods: This prospective study enrolled 133 living donors and 133 corresponding recipients. On the basis of the HomEM, HetEM, and PM CYP2C19 genotypes, the distributions of CYP3A4*18 (exon 10; T878C), CYP3A5*3 (intron 3; A6986G), and MDR1-3435 (exon 26; C3435T) genotypes were analyzed for single nucleotide polymorphisms among donors and recipients. Results: Among 102 HomEM genotypes, including 56 donors and 46 recipients, 91.2% of individuals harbored the T/T genotype of CYP3A4*18; 53.9% possessed G/G, and 34.3% had A/G genotypes of CYP3A5*3; and 38.2% had C/C and 50.0% had C/T genotypes at MDR1-3435. Among 130 HetEM genotypes, including 58 donors and 72 recipients, 97.7% of individuals possessed T/T genotype at CYP3A4*18; 50.0% harbored G/G and 41.5% had A/G genotypes at CYP3A5*3; and 40.0% had C/C and 49.2% had C/T genotypes at MDR1-3435. In 34 PMs, including 19 donors and 15 recipients, 88.2% had T/T genotypes at CYP3A4*18; 41.2% had G/G and 58.8% had A/G genotypes at CYP3A5*3; and 47.1% possessed C/C and 47.1% had C/T genotypes at MDR1-3435. On the basis of the CYP2C19 genotypes, no statistically significant distribution of genotypes were observed between donors and recipients for all genotypes of CYP3A4*18, CYP3A5*3, and MDR1-3435 (P >0.05). Conclusions: In conclusion, the CYP2C19 genotypes do not affect the expression of CYP3A4*18, CYP3A5*3, or MDR13435 variants, which are independently distributed among donors and recipients during LDLT.
Significance of Neuropeptides for Coexistence of Disturbances in Central Cardiovascular Control in Heart Failure, Stress and Depression

There are solid grounds for the recognition of the involvement of multiple neuronal/neurotransmitter networks in the regulation of the cardiovascular system. Clinical and preclinical studies provide evidence that heart failure is associated with significant changes in the central control of some of these systems. In addition, it has been shown that some of the brain's neurochemical pathways, which are involved in the central control of blood pressure, play a role in the regulation of emotions and cognitive functions. Stress and depression are regarded as potential challenges for the cardiovascular system, causing inappropriate regulation of cardiovascular parameters and worsening the prognosis of heart failure. There is also evidence that heart failure increases sensitivity to stress and depression. Recently, knowledge of the neurochemical background of comorbidity of stress, depression and heart failure has increased markedly. Our studies and those of other authors provided evidence for significant role of the improper function of neuropeptides, and in particular of the angiotensinergic, vasopressinergic and oxytocinergic systems in the exaggerated responsiveness of the cardiovascular system to stress in heart failure and depression. Current evidence indicates that the inappropriate regulation of the release of these neuropeptides and/or expression of their receptors play a particularly important role in long-term changes of central cardiovascular control during post-infarct heart failure.
Cilium-generated signaling: a cellular GPS?

Purpose of reviewThe discovery of the importance of proteins localized to cilia and basal bodies has provided novel insights into the pathogenesis of various human disorders including cystic kidney disease. The physiological role of cilium-generated signaling in most tissues including the kidney has remained elusive, however. This review focuses on the most recent advance in understanding a role for signaling through cilia for kidney biology. Recent findingsRecent work has tied the function of several developmental master regulators to cilium-generated signaling in vertebrates. Hedgehog signaling requires ciliary proteins and loss of targeting of its receptors and effectors to cilia abrogates Hedgehog function. Moreover, the ciliary protein inversin has been shown to act as a molecular switch for the regulation of Wnt signaling cascades. SummaryTogether with recent data on a function of cilia and basal body proteins in planar cell polarity in mice, a novel concept and testable hypothesis for the function of cilia in vertebrates is emerging: cilia may act as a cellular positioning device to allow subcellular asymmetry and polarization of the cells within the plane of the epithelium to develop and maintain regular arrays of cells such as kidney tubes.
Real-time Integration of Energy Storage

Increasing dynamics in power systems on account of renewable integration, electric vehicle penetration and rising demands have resulted in the exploration of energy storage for potential solutions. Recent technologyand industry-driven developments have led to a drastic decrease in costs of these storages, further advocating their usage. This thesis compiles the author’s research on optimal integration of energy storage. Unpredictability is modelled using random variables favouring the need of stochastic optimization algorithms such as Lyapunov optimization and stochastic approximation. Moreover, consumer interactions in a competitive environment implore the need of topics from game theory. The concept of Nash equilibrium is introduced and methods to identify such equilibrium points are laid down. Utilizing these notions, two research contributions are made. Firstly, a strategy for controlling heterogeneous energy storage units operating at different timescales is put forth. They strategy is consequently employed optimally for arbitrage in an electricity market consisting of day-ahead and real-time pricing. Secondly, energy storages owned by consumers connected to different nodes of a power distribution grid are coordinated in a competitive market. A generalized Nash equilibrium problem is formulated for their participation in arbitrage and energy balancing, which is then solved using a novel weighted Lyapunov approach. In both cases, we design real-time algorithms with provable suboptimality guarantees in terms of the original centralized and equilibrium problems. The algorithms are tested on realistic scenarios comprising of actual data from electricity markets corroborating the analytical findings. Real-time Integration of Energy Storage Sarthak Gupta General Audience Abstract Modern power system, which is responsible for generation and transport of electricity, is witnessing a lot of changes such as the increased adoption of wind and solar energy, promotion of electric vehicles, and ever increasing consumer demands. Amidst such developments, energy storage devices like batteries are being propagated as a necessary addition to the power system for its safe operation. This has been further supported by the decrease in prices of these devices over time. An effective assimilation of energy storage however, requires extensive mathematical studies on account of unpredictable renewable generation and consumer demands.This thesis focuses upon the preceding concern. To this note, two novel research contributions are made. In the first, an individual consumer is modeled who wishes to reduce his/her energy costs by simultaneously employing energy storages belonging to different technologies. In the latter, a more challenging multi-consumer interaction is reviewed where multiple end consumers wish to reduce costs while competing against each other over limited resources. In either of the cases, efficient algorithms are designed that are shown to produce desirable results over real-life data and have mathematically provable performance guarantees.
Hemorrhage and anticoagulation after nonseptic embolic brain infarction

Among 54 consecutive patients with acute nonseptic embolic brain infarction, there was CT evidence of hemorrhagic infarction in 1 patient (2%). None had clinical or CT evidence of massive brain hemorrhage even when anticoagulation therapy was used immediately. Seven patients (13%) had recurrent brain emboli, all within 7 days of the initial stroke. None of these patients was adequately anticoagulated at the time of recurrence. Immediate anticoagulation therapy should be employed after nonseptic embolic brain infarction if CT does not show hemorrhage and there is a persistent cardiac source of emboli.
Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids

LFA-1 expression allows liver-resident CD8+ T cells to patrol hepatic sinusoids yet remain in the liver. LFA-1 helps T cells feel at home in the liver Liver-resident T cells are critical to defense against infections such as malaria and hepatitis B virus. To protect the hepatic sinusoids, these cells must enter circulation yet still remain in the liver. McNamara et al. now report that liver-resident CD8+ T cells up-regulate LFA-1 and that LFA-1–ICAM-1 (intercellular adhesion molecule–1) interactions are critical for T cell patrolling of the hepatic sinusoids. Moreover, in the absence of LFA-1, CD8 T cells do not form liver-resident memory populations, even after infection with either Plasmodium or lymphocytic choriomeningitis virus. Thus, LFA-1 expression acts as a sort of invisible fence, allowing the liver-resident memory T cells free reign within the boundaries of the liver. Liver-resident CD8+ T cells are highly motile cells that patrol the vasculature and provide protection against liver pathogens. A key question is: How can these liver CD8+ T cells be simultaneously present in the circulation and tissue-resident? Because liver-resident T cells do not express CD103—a key integrin for T cell residence in epithelial tissues—we investigated other candidate adhesion molecules. Using intravital imaging, we found that CD8+ T cell patrolling in the hepatic sinusoids is dependent on LFA-1–ICAM-1 (intercellular adhesion molecule–1) interactions. Liver-resident CD8+ T cells up-regulate LFA-1 compared with effector memory cells, presumably to facilitate this behavior. Last, we found that LFA-1–deficient CD8+ T cells failed to form substantial liver-resident memory populations after Plasmodium immunization or lymphocytic choriomeningitis virus infection. Collectively, our results demonstrate that it is adhesion through LFA-1 that allows liver-resident memory CD8+ T cells to patrol and remain in the hepatic sinusoids.
Astrocyte Regulation of Endothelial Tissue Plasminogen Activator in a Blood-Brain Barrier Model

Expression of tissue plasminogen activator (tPA) substantially determines endothelial-dependent fibrinolysis. We used a blood-brain barrier (BBB) model to analyze regulation of brain capillary endothelial tPA and its inhibitor, plasminogen activator inhibitor-1 (PAI-1). This model consists of coculture of murine astrocytes with bovine brain capillary endothelial cells grown as capillary-like structures (CS); after 1 week, astrocytes become extensively associated with CS, and the BBB-associated enzyme γ-glutamyl transpeptidase is present. We measured tPA and PAI-1 mRNA and tPA activity in this model. Reverse transcription-polymerase chain reaction (RT-PCR) studies showed similar tPA and PAI-1 mRNA levels after 1 day mono-culture (endothelial cells only) versus astrocyte-endothelial coculture preparations. After 7 days (i.e., when elements of the BBB are present), astrocyte-endothelial cocultures (compared with endothelial mono-cultures) showed a 50.7% ± 27.1% (mean ± SD) reduction in tPA mRNA (P < 0.03) and a 183.3% ± 86.9% increase in PAI-1 mRNA expression (P < 0.02). Moreover, 7-day cocultures demonstrated reduced tPA activity compared with mono-cultures (14.6 ± 2.9 IU/mL versus 30.2 ± 7.7 IU/mL, P < 0.01); 1-day cocultures and mono-cultures had similar tPA activity. These findings demonstrate that astrocytes regulate brain capillary endothelial expression of tPA when elements of the BBB phenotype are present in this model. These data suggest an important role for astrocytes in the regulation of brain capillary endothelial fibrinolysis.
Virtualization and virtual router migration: Application and experimental validation

Virtualization and migration techniques have been largely investigated in Data Center applications to reduce the power consumption and to better utilize the physical resources. In this paper we studied the adoption of such techniques in an IP network and validate our approach in a real testbed based on the use of Software Routers. The contribution is organized in two parts. The first one is devoted to study and to evaluate a power saving solution for IP networks based on the virtualization and migration techniques. We also consider the integration of such techniques with a power saving solution available on network devices, i.e. adaptive link rate, able to adapt line cards power consumption to incoming traffic. The main results show that the effectiveness of the virtualization and migration techniques depends on the fixed power consumption of the routers and increases for high values of this component. The second part of the paper is devoted to evaluate the impact of router migration on the network performance; we consider two different virtualization environments, Linux Container (LXC) and Kernel-based Virtual Machine (KVM). The experimental results highlights that the impact of router migration, expressed by means of the downtime index, on network performance is negligible.
Building Accountability into the Internet of Things

Privacy is a matter of widespread societal concern, which will be further exacerbated by the ongoing effort to connect billions of data-generating devices to the Internet. The promise of large-scale social and economic benefits motivates the development of the Internet of Things. As a primary engine of personal data production in the near future it also carries with it real threats to privacy. Proposed legislation seeks to tackle these threats head-on. This paper seeks to explore principled ways in which systems design might engage with and respond to legal requirements to enable effective data protection and the projected utility of personal data in the digital economy. Key to this is the need to build accountability into the IoT to ensure compliance.
Reflectance of human skin using colour photometric stereo: with particular application to pigmented lesion analysis

Background/purpose: The optical appearance of human skin is highly dependent on the interaction between the illumination (type and position), observer position and the skin surface structure. Different currently available photographic techniques record different aspects of this appearance, each providing its own incomplete description. This limits their usefulness, especially for pigmented skin lesion diagnosis. In this paper a new, easy to use, low‐cost photographic method is described,which aims to generate an efficiently encoded yet reasonably complete representation of skin appearance.
the Role of Marketing Intelligence and Marketing Architecture Based Technology Assist in the Development of Business on the Msmes Maount Bromo Probolinggo in East Java

This research aims to provide a paradigm change business players in order to develop business in the manage with the help of a smart marketing and design technology sophisticated pengolaan governance and business can be developed with good, and can increase community economic welfare levels in the vicinity of micro and small and medium enterprises Mount Bromo Probolinggo East Java, empirically the economy in and around micro and small and medium enterprises probolinggo is still not optimal and the support of the government also has not been maximum attempts to help businesses on micro and small and medium enterprises around Gunung Bromo Probolinggo. Researchers attempting to help to resolve the problems of the economy in and around Mount Bromo by trying to examine the variables related to the smartphone technology-based marketing and technology based marketing design also in order to help the micro and small and medium enterprises can solve problems usahannya that there are still many obstacles. Researchers took samples around 100 people merchants who have micro and small and medium enterprises Business around Mount Bromo and using the methods of quantitative analysis and using the appliance AMOUS SAM analysis and location already determined around Mount Bromo, from a ) is expected to found a positive result against the business development of micro and small and medium enterprises and can help the sales profit level and can improve the level of technology used by entrepreneurs and increase the level of community welfare micro and small and medium enterprises Mount Bromo Probolinggo in East Java.
On the Limitations of Silicon for I-MOS Integration

This paper discusses the scalability of the supply voltage with the device length in silicon impact ionization MOS (I-MOS) transistors, by presenting results from both experiments and simulations. It is first shown that the supply voltage of silicon I-MOS devices saturates at low device lengths and does not fall under about 4.5 V. Second, it is shown from 2-D simulations and measurements on sub-100-nm devices that the transistor effect is lost also at low device lengths. We then propose an explanation for this phenomenon, based once again on the saturation of the supply voltage. Based on our findings, we conclude that silicon may be an inadequate material for I-MOS devices, and we envision germanium as a more promising replacement.