Miracle-dz/UniFAR-FTUs huggingface dataset:
A systematic review of methodological quality of model development studies predicting prognostic outcome for resectable pancreatic cancer

Objectives To assess the methodological quality of prognostic model development studies pertaining to post resection prognosis of pancreatic ductal adenocarcinoma (PDAC). Design/setting A narrative systematic review of international peer reviewed journals Data source Searches were conducted of: MEDLINE, Embase, PubMed, Cochrane database and Google Scholar for predictive modelling studies applied to the outcome of prognosis for patients with PDAC post resection. Predictive modelling studies in this context included prediction model development studies with and without external validation and external validation studies with model updating. Data was extracted following the Checklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies (CHARMS) checklist. Primary and secondary outcome measures Primary outcomes were all components of the CHARMS checklist. Secondary outcomes included frequency of variables included across predictive models. Results 263 studies underwent full text review. 15 studies met the inclusion criteria. 3 studies underwent external validation. Multivariable Cox proportional hazard regression was the most commonly employed modelling method (n=13). 10 studies were based on single centre databases. Five used prospective databases, seven used retrospective databases and three used cancer data registry. The mean number of candidate predictors was 19.47 (range 7 to 50). The most commonly included variables were tumour grade (n=9), age (n=8), tumour stage (n=7) and tumour size (n=5). Mean sample size was 1367 (range 50 to 6400). 5 studies reached statistical power. None of the studies reported blinding of outcome measurement for predictor values. The most common form of presentation was nomograms (n=5) and prognostic scores (n=5) followed by prognostic calculators (n=3) and prognostic index (n=2). Conclusions Areas for improvement in future predictive model development have been highlighted relating to: general aspects of model development and reporting, applicability of models and sources of bias. Trial registration number CRD42018105942
Relationship Between Very Cold Outside Weather and Surgical Outcome: Integrating Shallow and Deep Artificial Neural Nets

Patients' hospital length of stay (LOS) as a surgical outcome is important indicator of quality of care. We used EMR data to build artificial neural network models to better understand the impact of cold weather on outcome of first surgeries in a day in comparison to a matched cohort receiving surgical treatment in warm days. We found that LOS for first-in-a-day cardiac and orthopedic surgical cases are longer in very cold days.
INSTRUMENT ASSISTED SOFT-TISSUE MOBILIZATION: A COMMENTARY ON CLINICAL PRACTICE GUIDELINES FOR REHABILITATION PROFESSIONALS.

Instrument assisted soft-tissue mobilization (IASTM) has become a popular myofascial intervention for sports medicine professionals. Despite the widespread use and emerging research, a consensus on clinical standards, such as a describing the intervention, indications, precautions, contraindications, tool hygiene, safe treatment, and assessment, does not exist. There is a need to develop best practice standards for IASTM through a universal consensus on these variables. The purpose of this commentary is to discuss proposed clinical standards and to encourage other sports medicine professionals and researchers to contribute their expertise to the development of such guidelines. Level of Evidence 5.
Temporal and spatial variation in bacterial communities of “Jonagold” apple (Malus x domestica Borkh.) and “Conference” pear (Pyrus communis L.) floral nectar

Production of many agricultural crops and fruits strongly depends on pollinators. For instance, pome fruits such as apple and pear are highly dependent on pollination for fruit set, fruit quality, and yield. Nectar is often inhabited by microbes, most often yeasts and bacteria, which may change nectar quality and therefore also affect plant–pollinator interactions. Here, we used high‐throughput 16S ribosomal RNA gene amplicon sequencing to investigate the temporal and spatial variation in bacterial communities in floral nectar of apple and pear. We sampled 15 apple (Malus x domestica Borkh.) and 15 pear (Pyrus communis L.) orchards distributed over the eastern part of Belgium over a timespan of seven days. Nectar bacterial community composition differed strongly among fruit species. Nectar of pear was dominated by Actinobacteria, followed by Proteobacteria and Firmicutes. Apple nectar was strongly enriched in Bacteroidetes, a phylum which until now has been found to be rarely associated with floral nectar. Nectar was dominated by only a few bacterial species, with Brevibacterium (Actinobacteria) and Undibacterium (Proteobacteria) as the most abundant bacteria in pear and apple nectar, respectively. Bacterial richness and diversity were found to fluctuate during flowering, likely due to changing environmental conditions. Additionally, spatial structure in nectar bacterial community composition was found in apple orchards, while this was not the case for pear. Differences in nectar bacterial communities between apple and pear nectar may differently affect the chemical and nutritional composition of the nectar, influencing pollinator attraction and visitation, and thus pollination efficacy in general.
User data spectrum theory: Collecting, interpreting, and implementing user data in organizations

Organizations interested in increasing their user experience (UX) capacity lack the tools they need to know how to do so. This dissertation addresses this challenge via three major research efforts: 1) the creation of User Data Spectrum theory and a User Data Spectrum survey for helping organizations better invest resources to grow their UX capacity, 2) a new UX method and model for organizations that want to capitalize on spoken words from end users called Rapid Meaningful Scenarios (RMS), and 3) a recommendation for UX education in response to the current ACM SIGCHI education Living Curriculum initiative. The User Data Spectrum work is based on 30 interviews and 110 survey responses from UX stakeholders across 120 companies. These data informed the theory as well as a factor analysis performed to identify the most relevant items in the User Data Spectrum survey. The Rapid Meaningful Scenarios methodology was developed based on iterative UX experience with a real-world organization and refined to aid UX professionals in creating structured results based on end users' words. The UX education recommendation integrates experience with the HCI curriculum at Iowa State University and curriculum discussions within the SIGCHI community over the past 5 years. The overall contribution of this research is a set of tools that will enable UX professionals and organizations to better strategize how to increase their UX capacity.
Application of Process Metrics to Compare Children's Asthma Diagnostic Pathways in 30 EU/EEA Countries

The paper presents the results of the application of the business process approach to analyse and compare healthcare pathways performed in 30 EU/EEA countries focusing on children's asthma care. The adoption of process metrics allows the identification of different levels of fragmentation across countries resulting from the interactions among primary and secondary healthcare professionals as well as from parents' involvement in the process.
Component Based Regression Testing Approaches Without Source Code

Various regression testing techniques have been developed, but most of the techniques are based on the source code for change identification. So, the testers are facing different challenges in performing effective testing. The goal of this research is to find out the different approaches that are used to identify changes in modified COTS component, analyze the main characteristics of those approaches and investigate how these characteristics can be used in selection and development of CBRT approach. To fulfill the aims of the research, we have conducted systematic literature review of different CBRT approaches from the year 1993-2010. From systematic literature we found out 32 papers relevant to our study. Data related to our research are extracted from those papers and conclusion is made.
Using an Artificial Intelligence-Based Argument Theory to Generate Automated Patient Education Dialogues for Families of Children with Juvenile Idiopathic Arthritis

Juvenile Idiopathic Arthritis (JIA) is the most common chronic rheumatic disease of childhood, with outcomes including pain, prolonged dependence on medications, and disability. Parents of children with JIA report being overwhelmed by the volume of information in the patient education materials that are available to them. This paper addresses this educational gap by applying an artificial intelligence method, based on an extended model of argument, to design and implement a dialogue system that allows users get the educational material they need, when they need it. In the developed system, the studied model of argument was leveraged as part of the system's dialogue manager. A qualitative evaluation of the system, using cognitive walkthroughs and semi-structured interviews with JIA domain experts, suggests that these methods show great promise for providing quality information to families of children with JIA when they need it.
National, Regional, State, and Selected Local Area Vaccination Coverage Among Adolescents Aged 13–17 Years — United States, 2018

The Advisory Committee on Immunization Practices (ACIP) recommends routine vaccination of persons aged 11-12 years to protect against certain diseases, including human papillomavirus (HPV)-associated cancers, meningococcal disease, and pertussis (1). A booster dose of quadrivalent meningococcal conjugate vaccine (MenACWY) is recommended at age 16 years, and serogroup B meningococcal vaccine (MenB) may be administered to persons aged 16-23 years (1). To estimate vaccination coverage among adolescents in the United States, CDC analyzed data from the 2018 National Immunization Survey-Teen (NIS-Teen) which included 18,700 adolescents aged 13-17 years. * During 2017-2018, coverage with ≥1 dose of HPV vaccine increased from 65.5% to 68.1%, and the percentage of adolescents up-to-date† with the HPV vaccine series increased from 48.6% to 51.1%, although the increases were only observed among males. Vaccination coverage increases were also observed for ≥1 MenACWY dose (from 85.1% to 86.6%) and ≥2 MenACWY doses (from 44.3% to 50.8%). Coverage with tetanus and reduced diphtheria toxoids and acellular pertussis vaccine (Tdap) remained stable at 89%. Disparities in coverage by metropolitan statistical area (MSA)§ and health insurance status identified in previous years persisted (2). Coverage with ≥1 dose of HPV vaccine was higher among adolescents whose parents reported receiving a provider recommendation; however, prevalence of parents reporting receiving a recommendation for adolescent HPV vaccination varied by state (range = 60%-91%). Supporting providers to give strong recommendations and effectively address parental concerns remains a priority, especially in states and rural areas where provider recommendations were less commonly reported.
ACUTE EFFECTS OF NEURAL GLIDING ON ATHLETIC PERFORMANCE.

Background Neural mobilization has been used to treat individuals with musculoskeletal and neuromuscular pathologies, but research on neural mobilization in sports rehabilitation is scarce. Furthermore, there have been no studies investigating the effects of neural gliding on sport performance. Purpose/Hypothesis The purpose of this study was to examine the differences between the acute effects of sciatic nerve gliding and lower extremity dynamic stretching exercises on hamstring flexibility and athletic performance. Study Design A cross-sectional, quasi-experimental design with block assignment was used. Methods Twenty-seven (16 males, 11 females, age: 23.6 ± 2.65, height (m): 1.74 ± 0.12, weight (kg): 73.73 ± 16.09) healthy college students volunteered for the study. The neural gliding group had 14 subjects and the dynamic stretching group had 13 subjects. Participants performed a jogging or walking up stairs warm up at a self-selected pace prior to testing. Baseline data was obtained for each of the following measurements: bilateral hamstring flexibility using the active straight leg raise test measured by a digital inclinometer, vertical jump height, 20-yard shuttle run and 10 and 20-yard dash sprint. The participants then performed one of the assigned five-minute stretching protocol, bilateral sciatic neural gliding or dynamic stretching of the lower extremities, followed by the post-test data collection of the same measures. Results There were no significant group by time interaction for any of the six measurements (2 x 2 repeated measures ANOVA). However, significant time differences, pre-test vs post-test for all participants as one group, for right hamstring length (p = .001), left hamstring length (p = .002) and vertical jump (p = .028) were observed. Post hoc paired t-tests found a significant increase between the pre and post-tests in right hamstring flexibility, (p = .011) in the dynamic stretching group and left hamstring flexibility of participants in the neural gliding condition, (p = .004). When analyzing the groups individually, pre-test vs post-test, a significant difference in vertical jump was not observed in either group. Conclusion Similar improvement in hamstring flexibility with both dynamic stretching and neural gliding exercises without a negative effect on three sports performance tests was demonstrated. Therefore, athletic performance will not be negatively affected by a pre-participation warm-up which includes neural gliding, but more research is needed. Level Of Evidence Level 3.
Platelet activation in diabetic mice models: the role of vascular endothelial cell-derived protein disulfide isomerase-mediated GP IIb/IIIa receptor activation

GP IIb/IIIa receptor activation plays an important role in thrombosis. The mechanism of early activation of GP IIb/IIIa receptors in diabetic conditions remains unknown. The purpose of this study was to investigate the release of Endothelial microparticle (EMP)-associated protein disulfide isomerase (PDI) after endothelial cell injury induced in diabetes and the changes in platelet activation. We produced an animal model of type 2 diabetes mellitus using ApoE−/− mice. Normal ApoE−/− and diabetic mice were allocated to four groups (n = 15): normal diet, normal diet plus rutin, diabetic, and diabetes plus rutin. The EMP-PDI content and GP IIb/IIIa expression of mice platelets were determined. In addition, EMPs obtained from the four groups were pretreated with the PDI inhibitor rutin; then, their effects on the platelets of normal C57 mice were characterized. Compared with the normal diet group, the diabetic group had significantly increased plasma EMP-PDI content and accelerated platelet activation by increased GP IIb/IIIa expression. In conclusion, EMP-PDI promotes early platelet activation through glycoprotein (GP) IIb/IIIa receptors present on platelet surface in the diabetic state. However, this process could be partially suppressed by the administration of rutin.
Implantable Cardioverter Defibrillator Shocks and Psychological Distress: Examining the Mediating Roles of Implantable Cardioverter Defibrillator-Related Concerns and Perceived Control.

BACKGROUND Although the implantable cardioverter defibrillator (ICD) has a survival benefit for the prevention of sudden cardiac death, ICD recipients commonly experience emotional distress as a consequence of ICD shocks. OBJECTIVE The aim of this study was to examine whether the association between ICD shocks and psychological distress (anxiety and depressive symptoms) is mediated by ICD-related concerns and perceived control among ICD recipients. METHODS This was a multinational cross-sectional observational study of 334 ICD recipients. Patients reported the number of shocks received since ICD implantation and completed questionnaires to assess anxiety, depressive symptoms, ICD-related concerns, and perceived control. A path analysis was conducted to explore the relationship of receiving ICD shocks with anxiety and depressive symptoms and the mediating effects of ICD-related concerns and perceived control. RESULTS Of the 334 ICD recipients, 39.2% experienced ICD shocks at least once since implantation. There was no direct effect of ICD shocks on anxiety and depressive symptoms. Experiencing ICD shocks was indirectly associated with an increased likelihood of anxiety and depressive symptoms via the pathways of ICD-related concerns and perceived control (indirect effects on anxiety = 0.060, 0.043; indirect effect on depressive symptoms = 0.025, 0.073). CONCLUSION Experiencing defibrillator shocks was associated with psychological distress in ICD recipients; the relationship was fully mediated by ICD-related concerns and perceived control. These results suggest that clinicians should routinely assess ICD-related concerns and perceived control in patients with ICD. Research is needed to develop and test interventions to decrease emotional distress related to the ICD shock experience.
Finite element analysis of spiral plate and Herbert screw fixation for treatment of midshaft clavicle fractures

Abstract Both spiral plate and Herbert screw fixations have been clinically adopted for treating midshaft displaced clavicle fractures. However, the biomechanical properties of the 2 implant fixations have not yet been thoroughly evaluated. Here we report the results of a finite element analysis of the biomechanical properties of midshaft clavicle fractures treated with Herbert screw and spiral plate fixation. Hebert screw fixation showed stress distribution similar to intact clavicle under all loading conditions, but provided less stability than did spiral plate fixation. Postoperatively, excessive shoulder activities and weight-bearing should be avoided. Spiral plate fixation provides greater stability, but is associated with stress shielding. These results demonstrate that Herbert screw fixation is suitable for the treatment of simple displaced clavicluar fractures, but excessive shoulder activity and weight-bearing should be avoided after the operation. Therefore, spiral plate fixation may be preferred for patients requiring an early return to activity.
Mechanisms of Energy Metabolism in Skeletal Muscle Mitochondria Following Radiation Exposure

An understanding of cellular processes that determine the response to ionizing radiation exposure is essential for improving radiotherapy and assessing risks to human health after accidental radiation exposure. Radiation exposure leads to many biological effects, but the mechanisms underlying the metabolic effects of radiation are not well known. Here, we investigated the effects of radiation exposure on the metabolic rate and mitochondrial bioenergetics in skeletal muscle. We show that ionizing radiation increased mitochondrial protein and mass and enhanced proton leak and mitochondrial maximal respiratory capacity, causing an increase in the fraction of mitochondrial respiration devoted to uncoupling reactions. Thus, mice and cells treated with radiation became energetically efficient and displayed increased fatty acid and amino acid oxidation metabolism through the citric acid cycle. Finally, we demonstrate that radiation-induced alterations in mitochondrial energy metabolism involved adenosine monophosphate-activated kinase signaling in skeletal muscle. Together, these results demonstrate that alterations in mitochondrial mass and function are important adaptive responses of skeletal muscle to radiation.
ROR1 and ROR2—novel targets for neuroblastoma

Abstract Background: Despite advances in immunotherapeutic strategies for neuroblastoma (NBL), relapse remains a significant cause of mortality for high risk patients. The discovery of novel tumor associated antigens to improve efficacy and minimize the toxicities of immunotherapy is therefore warranted. Receptor Tyrosine Kinase-like Orphan Receptor-1 and 2 (ROR1 and ROR2) have been found to be expressed in several malignancies with limited expression in healthy tissues. Objectives: Given their role in tumor migration and proliferation and the fact that they were originally cloned from a NBL cell line, we hypothesized that ROR1 and ROR2 could serve as potential targets for anti-ROR1 and anti-ROR2 based immunotherapies in NBL. Methods: We characterized the mRNA and protein expression of ROR1 and ROR2 in NBL cell lines and tissue microarrays of patient samples. To explore the potential of ROR1 targeting, we performed in vitro cytotoxicity assays against NBL using NK92 cells as effector cells. Results: Both ROR1 and ROR2 are expressed across all stages of NBL. In patients with non-MYC amplified tumors, expression of ROR1/ROR2 correlated with survival and prognosis. Moreover, in a proof-of-concept experiment, pretreatment of NBL cell line with anti-ROR1 antibody showed additive cytotoxicity with NK92 cells. Conclusions: ROR1 and ROR2 could serve as novel targets for immunotherapy in NBL. The additive effect of anti-ROR1 antibodies with NK cells needs to be explored further to evaluate the possibility of combining anti-ROR1 antibodies with immune effectors such as NK92 cells as a potential off-the shelf immunotherapy for NBL and other ROR1 expressing malignancies.
Antagonistic Effects of IL-4 on IL-17A-Mediated Enhancement of Epidermal Tight Junction Function

Atopic dermatitis (AD) is the most common chronic and relapsing inflammatory skin disease. AD is typically characterized by skewed T helper (Th) 2 inflammation, yet other inflammatory profiles (Th1, Th17, Th22) have been observed in human patients. How cytokines from these different Th subsets impact barrier function in this disease is not well understood. As such, we investigated the impact of the canonical Th17 cytokine, IL-17A, on barrier function and protein composition in primary human keratinocytes and human skin explants. These studies demonstrated that IL-17A enhanced tight junction formation and function in both systems, with a dependence on STAT3 signaling. Importantly, the Th2 cytokine, IL-4 inhibited the barrier-enhancing effect of IL-17A treatment. These observations propose that IL-17A helps to restore skin barrier function, but this action is antagonized by Th2 cytokines. This suggests that restoration of IL-17/IL-4 ratio in the skin of AD patients may improve barrier function and in so doing improve disease severity.