Miracle-dz/UniFAR-FTUs huggingface dataset:
Trans-arterial chemoembolization (TACE) in treatment of non-resectable hepatocellular carcinoma: comparative study between conventional TACE and drug eluting bead TACE

To compare tumour response and complications of conventional TACE with lipidol versus DEB-TACE in the treatment of non-resectable HCC.Prospective non randomized comparative clinical trial was performed for patients receiving TACE at interventional radiology unit in Radiodiagnosis department in Zagazig university hospitals. Forty patients were included in this study, 16 patients were treated with drug eluting beads TACE and 24 patients were treated with conventional TACE.Follow up triphasic CT was performed 1 month after the procedure, we found that complete response was 6 cases (25 %) in c TACE group, and 4 cases (25%) in drug eluting bead TACE group, Partial response was achieved in 11 cases (45.8%) in c TACE group, and in 8 cases (50 %) in DEBs-TACE group, Cases with stable disease were 5 cases (20.8%) in c TACE group, and it was 3 cases (18.7%) in DEBs-TACE group, progressive disease is noted in two cases (8.3 %) in c TACE group, and one case (6.2 %) in drug eluting TACE group. Complications were as follow: 18 cases (75%) with abdominal pain in c TACE group, and 6 cases (37.5%) with abdominal pain in DEBs-TACE group, Nausea and vomiting were noted in 13 cases (54.17%) in c TACE group and in 3 cases (18.75%)in DEBs TACE group, Alopecia was noted in 8 cases (33.3 %) in c TACE group and in one case (6.25%) in DEBs TACE group.There were no significant differences between two groups regarding tumour response after 1 month. Almost all complications were significantly lower in DEBs-TACE group than in c TACE group, especially with abdominal pain, nausea, vomiting and alopecia. Abbreviations: c TACE: conventional trans-arterial chemoembolization, DEB TACE: drug eluting beads trans-arterial chemoembolization, HCC: hepatocellular carcinoma, CR: complete response, PR: partial response, SD: stable disease, PD: progressive disease.
Natural Enemies and the Maintenance of Tropical Tree Diversity: Recent Insights and Implications for the Future of Biodiversity in a Changing World1

Abstract Over the past five decades, many studies have examined the Janzen-Connell hypothesis, which posits that host-specific natural enemies, such as insect herbivores and fungal pathogens, promote plant species coexistence by providing a recruitment advantage to rare plant species. Recently, researchers have been exploring new and exciting angles on plant-enemy interactions that have yielded novel insights into this long-standing hypothesis. Here, we highlight some empirical advances in our understanding of plant-enemy interactions in tropical forests, including improved understanding of variation in plant species' susceptibility to enemy effects, as well as insect and pathogen host ranges. We then review recent advances in related ecological theory. These theoretical studies have confirmed that specialist natural enemies can promote tree diversity. However, they have also shown that the impact of natural enemies may be weakened, or that natural enemies could even cause species exclusion, depending on enemy host range, the spatial extent of enemy effects, and variation among plant species in seed dispersal or enemy susceptibility. Finally, we end by discussing how human impacts on tropical forests, such as fragmentation, hunting, and climate change, may alter the plant-enemy interactions that contribute to tropical forest diversity.
Multi-Dimensional Fraud Detection Metrics in Business Processes and their Application

Occupational fraud is defined as the deliberate misuse of one’s occupation for personal enrichment. It poses a significant challenge for organizations and governments. Estimates indicate that the funds involved in occupational fraud cases investigated across 125 countries between 2018 and 2019 exceeded US$3.6 billion. Process-based fraud (PBF) is a form of occupational fraud that is perpetrated inside business processes. Business processes underlie the logic of the work that organizations undertake, and they are used to execute an organization’s strategies to achieve organizational goals. Business processes should be examined for potential fraud risks to ensure that businesses achieve their objectives. While it is impossible to prevent fraud entirely, it must be detected. However, PBF detection metrics are not well developed at present. They are scattered, unstandardized, not validated, and, in some cases, absent. This study aimed to develop a comprehensive PBF detection metric by leveraging and operationalizing a taxonomy of fraud detection metrics for business processes as an underlying theory. 41 PBF detection metrics were deduced from the taxonomy using design science research. To evaluate their utility, the application of the metrics was undertaken using illustrative scenarios, and a real example of the implementation of the metrics was provided. The developed metrics form a complete, classified, validated, and standardized list of PBF detection metrics, which include all the necessary PBF detection dimensions. It is expected that the stakeholders involved in PBF detection will use the metrics established in this work in their practice to increase the effectiveness of the PBF detection process.
The investigation of Orthoptera from Huagaoxi Nature Reserve of Sichuan, China

We conducted a survey for Orthoptera in the Huagaoxi Nature Reserve of Sichuan for the first time during the summer of 2013. The result deals with 22 genera 35 species of superfamily Tettigonioidea, 10 genera 11 species of superfamily Acridoidea, and 14 genera 20 species of family Gryllidae, 1 genus 1 species of family Gryllotalpidae. In addition, Gampsocleis sinensis (Walker, 1871) is one newly recorded species of Sichuan.
Actual Problems of the Hotel and Restaurant Business Development

consumers’ needs. The modelling method helped to determine how communications could be formed in the process of implementation of foresight sessions for the restaurant business development. To assess the prospects for the development of the restaurant business, aspects of the pre-crisis (pre-quarantine and pre-war) as well as expectations (customers’, investors’ and subjects’ of the restaurant business) of the post-war periods were compared. Results. The key term “foresight” and its main predictors were defined. The components of the complex monitoring and prognostication mechanism were worked out: political, economic, technological and market foresight. An overview of the most important tendencies and trends in the national and global business environment was presented in order to identify and detail the problems and challenges facing restaurant establishments in future. Prospects for further research base on the elaboration of alternative scenarios for the restaurant business development through the foresight methodology. Conclusions and discussion. Restaurant business foresight studies use sophisticated methods, still, they rarely involve all stakeholders, including consumers. The authors pay special attention to the monitoring of political, economic, technological and market environment, as well as to digital technologies, which are already significantly changing approaches to business development. The analysis of Ukrainian subjects of the restaurant business makes it possible to evaluate strategic maps as a foresight tool, which is complemented by active prognostic methods. Based on the peculiarities of the restaurant business and market tendencies, four scenarios are defined: crisis experience (“freezing and adaptation”); anti-crisis benchmarking (“global expectations”); breakthrough innovations (“motivational attack”); resuscitation scenarios (“struggle and recovery”). All these scenarios describe oriented principles for the development of the restaurant business. They are practical for scientists and practitioners, as they provide a basis for elaborating and evaluating development strategies for both individual business entities and the restaurant industry in total.
Wehrlites from continental mantle monitor the passage and degassing of carbonated melts

doi: 10.7185/geochemlet.2031 Continental rifting has been linked to the thinning and destruction of cratonic lithosphere and to the release of enough CO2 to impact the global climate. This fundamental plate tectonic process facilitates the infiltration and mobilisation of smallvolume carbonatedmelts, whichmay interact withmantle peridotite to formwehrlite through the reaction: enstatiteþ dolomite (melt)= forsteriteþ diopsideþCO2 (vapour). Application to mantle xenolith suites from various rifts and basins shows that 2.9 to 10.2 kg CO2 are released per 100 kg of wehrlite formed. For the Eastern Rift (Africa), this results in estimatedCO2 fluxes of 6.5 ± 4.1Mt yr−1, similar to estimates of mantle contributions based on surficial CO2 surveys. Thus, wehrlite-bearing xenolith suites can be used to monitor present and past CO2 mobility through the continental lithosphere, ultimately with diffuse degassing to the atmosphere. They may also reveal the CO2 flux in lithospheric provinces where carbonated melts or continent-scale rifts are not observed at the surface. Received 2 May 2020 | Accepted 17 August 2020 | Published 25 September 2020
Epithelial-mesenchymal transition: a hallmark in pancreatic cancer stem cell migration, metastasis formation, and drug resistance

Metastasis, tumor progression, and chemoresistance are the major causes of death in patients with pancreatic ductal adenocarcinoma (PDAC). Tumor dissemination is associated with the activation of an epithelial-to-mesenchymal transition (EMT) process, a program by which epithelial cells lose their cell polarity and cell-to-cell adhesion, and acquire migratory and invasive abilities to become mesenchymal stem cells (MSC). These MSCs are multipotent stromal cells capable of differentiating into various cell types and trigger the phenotypic transition from an epithelial to a mesenchymal state. Therefore, EMT promotes migration and survival during cancer metastasis and confers stemness features to particular subsets of cells. Furthermore, a major problem limiting our ability to treat PDAC is the existence of rare populations of pancreatic cancer stem cells (PCSCs) or cancer-initiating cells in pancreatic tumors. PCSCs may represent sub-populations of tumor cells resistant to therapy which are most crucial for driving invasive tumor growth. These cells are capable of regenerating the cellular heterogeneity associated with the primary tumor when xenografted into mice. Therefore, the presence of PCSCs has prognostic relevance and influences the therapeutic response of tumors. PCSCs express markers of cancer stem cells (CSCs) including CD24, CD133, CD44, and epithelial specific antigen as well as the drug transporter ABCG2 grow as spheroids in a defined growth medium. A major difficulty in studying tumor cell dissemination and metastasis has been the identification of markers that distinguish metastatic cancer cells from cells that are normally circulating in the bloodstream or at sites where these cells metastasize. Evidence highlights a linkage between CSC and EMT. In this review, The current understanding of the PCSCs, signaling pathways regulating these cells, PDAC heterogeneity, EMT mechanism, and links between EMT and metastasis in PCSCs are summarised. This information may provide potential therapeutic strategies to prevent EMT and trigger CSC growth inhibition and cell death.
Protective Effects of Silymarin on Gentamicin-Induced Nephrotoxicity in Infectious Patients: A Randomized Double Blinded Placebo-Controlled Clinical Trial

Background: Nephrotoxicity is one of the most important side effects of gentamicin (GEN). Accumulating evidence demonstrated the crucial roles of antioxidant compounds in the reduction of GEN-induced renal injuries. Silymarin (SM),an antioxidant agent,was demonstrated toimprove GEN-induced kidney damage. The aim of this clinical trial was to investigate the effect of SMon GEN-induced nephrotoxicity. Methods: This randomized, double-blinded, placebo-controlled clinical trial was conducted from April 2017 to October 2019 on patients diagnosed with infectious diseases receiving GEN at least for 7 days. After approving the study and obtaining informed consents, 60 patients were included in this study. Patients in the treatment (30) and control (30) groups were given injectable GEN along with 140 mg of SM tablets or placebo orally three times a day, respectively. Demographic, laboratory, and therapeutic profilesof the patients were recorded. Urine and blood samples were collected before and on days 1, 2, 3, 5 and 7 after GEN administration and intervention. Results: Sex, age, GEN indication and baseline glomerular filtration rateswere found to haveno effect on GEN nephrotoxicity. SM- and placebo-treated groups exhibited no significant differencesbetweenthe indications and intervals of GEN administration. The overall rate of GEN nephrotoxicity in the SM group was significantly lower than that in the placebo group (16.7% and 53.3%, respectively; p: 0.003). In addition, the risk of GEN nephrotoxicity in patients receiving placebowas significantly higher than those receivingSM(OR:12.69, 95%, CI: 1.38-116.74; p:0.03). Serum creatininewasfound to be significantly higher in the placebo-treated group than that in theSM-treatedgroup (p<0.05). However, the frequency of acute tubular necrosis on days 2, 3, 5, and 7 after GEN administration exhibited no significant differences between SM- and placebo-treated patients. Conclusion: This study demonstratedthat SM could attenuate renal injury in GEN-treated patients.
Efficacy of some selected botanicals and broad spectrum pesticides against foliage insect pests of cultivars of potato (Solanum tuberosum L.) in Zoba Anseba, Eritrea

Potato is one of the major vegetable crops after tomato and onion in Eritrea. This crop is highly attacked by many insect pests mainly Whiteflies, Aphids and Jassids. In Eritrea, limited research is done before on insect pest of potato hence this study aimed to know the most serious foliar insect pests and to determine the relative efficacy and performance of the common potato cultivars and the selected insecticides respectively. The experiment was conducted at Hamelmalo Agricultural College farm station, Eritrea using three potato cultivars (Picasso, Ajiba and Zafira). The design of the experiment was randomized complete block in triplicate. Besides two broad spectrum pesticides (deltamethrin, dimethoate) and two botanicals; neem seed kernel and tobacco leaf extracts were used. Data on the population count of insect pests before and after each spray were recorded. Whiteflies, aphids, jassids and red spider mites were identified and the result showed the highest aphid population reduction during tobacco leaf extracts spray followed by deltamethrin and neem seed extracts sprays respectively. Nevertheless, there was no significant difference between deltamethrin and neem seed extracts sprays in whitefly reduction and tobacco leaf and neem seed extracts sprays in reducing jassids population. The results further indicated maximum insect pest count in Ajiba and Zafira cultivars while Picasso showed minimum counts which indicate relative tolerance of the cultivar. The correlation analysis indicated, there was no significant association among insect pests and yield ha-1. However, the growth parameters showed significant correlations with yield ha-1 at 0.01% level of significance.
Automatic Discrimination of Apraxia of Speech and Dysarthria Using a Minimalistic Set of Handcrafted Features

To assist clinicians in the differential diagnosis and treatment of motor speech disorders, it is imperative to establish objec-tive tools which can reliably characterize different subtypes of disorders such as apraxia of speech (AoS) and dysarthria. Ob-jective tools in the context of speech disorders typically rely on thousands of acoustic features, which raises the risk of difﬁcul-ties in the interpretation of the underlying mechanisms, over-adaptation to training data, and weak generalization capabilities to test data. Seeking to use a small number of acoustic features and motivated by the clinical-perceptual signs used for the differential diagnosis of AoS and dysarthria, we propose to characterize differences between AoS and dysarthria using only six handcrafted acoustic features, with three features reﬂecting segmental distortions, two features reﬂecting loudness and hyper-nasality, and one feature reﬂecting syllabiﬁcation. These three different sets of features are used to separately train three classi-ﬁers. At test time, the decisions of the three classiﬁers are combined through a simple majority voting scheme. Preliminary re-sults show that the proposed approach achieves a discrimination accuracy of 90 %, outperforming using state-of-the-art features such as openSMILE which yield a discrimination accuracy of 65 %.
Bloodstream infections in intensive care unit: retrospective study in a teaching hospital

The objective of this study was to verify the risk factors and epidemiological profile of the patients diagnosed with bloodstream infection, as well as the microorganisms responsible for the infection. A cross-sectional study was carried out in which blood cultures were collected and data were collected from patients admitted to an adult intensive care unit with a diagnosis of bloodstream infection during the year 2016. Information about the patient and hospitalization was collected, as well as the agent responsible for the infection ‘and its resistance profile. 24 blood cultures positive for bacterial growth were included. The mean age of the patients was 53.9±21.1 years and 54.5% of the patients affected by the infection were men. Of the patients, 59.1% had a history of heart disease, of which 63.6% died. Gram positive bacteria were more related to infection, in which 54.2% were coagulase negative Staphylococcus and of these, 76.9% were resistant to methicillin. It was identified that the male sex, elderly individuals and with history of some previous comorbidities, especially heart diseases, were the most affected with bacteremia. As for the bacterial agent responsible for the infection, Coagulase negative Staphylococcus was the most related to the diagnosed cases, as well as its high resistance profile of this microorganism against methicillin.
Importance of activation energy and heat source on nanoliquid flow with gyrotactic microorganisms

This article addresses salient features of gyrotactic microorganism and activation energy in flow of nanofluid by rotating disk. An exponential space dependent heat source (ESHS) process is implemented to examine the thermal transport characteristics. Additionally nanoparticles mass flux condition is considered. The solutions are numerically computed. Impacts of various physical variables appearing in the solutions of non-linear systems are carefully analyzed. The current work identifies that temperature distribution of nanoliquid enhances for higher values of thermophoresis and Brownian motion variables. Moreover activation energy and temperature difference parameters diminish the nanoparticles concentration. Comparative study is provided in order to validate our outcomes.
Catalase Activity and Hydrophobicity Test of Bacteria Susceptible to Extracts of Cleistopholis Patens and Piliostigma Reticulatum

Antibacterial effect of the ethanol, methanol and ethyl acetate extracts of Piliostigma reticulatum and Cleistopholis patens on ten pathogenic bacteria including Pseudomonas aeruginosa, Salmonella typhi, Escherichia coli, Proteus vulgaris, Streptococcus pyogenes, Klebsiella aerogenes, Staphylococcus aureus, Serratia marscences, Yersinia enterocolitica and Shigella dysenteriae was investigated. Survival rate after treatment was investigated. Cell surface hydrophobicity after treatment was tested and the catalase activities of the plant extracts were determined. The results revealed that at 100mg/ml of extracts, the ethanol extracts of C. patens showed antibacterial activities against S. typhi, P. vulgaris, Str. pyogenes, K. aerogenes, Saureus and Yersinia enterocolitica with zones of inhibition of 18mm, 14mm, 18mm, 24mm, 14mm and 18mm respectively and the ethyl acetate extract was active against Sal. typhi, P. vulgaris, Str. pyogenes, K. aerogenes, S. aureus Ser. marscences and Y. enterocolitica with zones of inhibition of 14mm, 22mm, 18mm, 18mm, 14mm, 16mm and 16mm respectively while ethanol extract of P. reticulatum showed activity against P. aeruginosa, Sal. typhi, E.coli, Str. pyogenes, K. aerogenes, S. aureus, and Sh. dysenteriae with zones of inhibition of 13mm, 12mm, 10mm, 10mm, 8mm, 10mm and 14mm respectively. The ethyl acetate was active against E.coli, Str. pyogenes, K. aerogenes, S. aureus and Sh. dysenteriae respectively. The methanol extract had no activity against the test organisms. The kill- time curve showed that susceptible cells die after 10 and 20minutes after contact with the extracts of C. patens for most of the test bacteria while cell death occurred at 10, 20, 40, 50 and 60 min after contact. The hydrophobicity test showed that test organisms had hydrophobicity of between 47% and 99% in the extracts. Catalase production reduced considerably in some bacteria after treatment with plant extracts. The results obtained presupposes that the plant extracts are effective against some of the test organisms and their mode of activity are is that they interfere with the ability of bacteria to produce catalase, inducing cell death by the production of hydroxyl radical and also by to the enhancement of non-opsonic phagocytosis of bacteria by macrophages.
IONISE: An Ionospheric Observational Network for Irregularity and Scintillation in East and Southeast Asia

An Ionospheric Observational Network for Irregularity and Scintillation in East and Southeast Asia (IONISE) is developed to identify and study the short‐term and fine‐scale ionospheric variations over China. The IONISE network mainly includes three crossed chains of Beidou geostationary satellite total electron content (TEC)/scintillation receivers along 110°E, 23°N, and 40°N respectively, multistatic portable digital ionosondes and bistatic very high‐frequency radars. Based on the IONISE observations, we report some preliminary results of ionospheric disturbances and irregularities, including (1) initially generated and zonally drifting equatorial plasma bubbles and related scintillations, (2) traveling ionospheric disturbances from middle to low latitudes, (3) drift of strong sporadic E structures over a wide area of more than 1,000 km, (4) fine‐scale ionospheric perturbation and regional TEC gradient, and (5) general features of ionospheric response to geomagnetic storms. Possible mechanisms responsible for these ionospheric phenomena are discussed. The IONISE provides new data set for investigation on ionospheric disturbances of various scales in a broad region with dense observations along specific latitude/longitude.
Artificial Intelligence Using DBS-QOS In Banking Organizations

– Quality of service, that is, the waiting time that customers must endure in order to receive a service, is a critical performance aspect in private and public service organizations. P1 voiding good service quality is particularly important in highly competitive sectors where similar services exist. In this paper, focusing on banking sector, we propose an artificial intelligence system for building a model for the prediction of service quality. While the traditional approach used for building analytical models relies on theories and assumptions about the problem at hand, we propose a novel approach for learning models from actual data. Thus, the proposed approach is not biased by the knowledge that experts may have about the problem, but it is completely based on the available data. The system is based on a recently defined variant of genetic programming that allows practitioners to include the concept of semantics in the search process. This will have beneficial effects on the search process and will produce analytical models that are based only on the data and not on domain-dependent knowledge.