Miracle-dz/UniFAR-FTUs huggingface dataset:
Evidence for Weak Selective Constraint on Human Gene Expression

Variation in human complex traits is connected to variation in gene expression, and selection on complex traits can be reflected in selection on gene expression. Here, Glassberg and Gao et al. analyze polymorphic. Gene expression variation is a major contributor to phenotypic variation in human complex traits. Selection on complex traits may therefore be reflected in constraint on gene expression. Here, we explore the effects of stabilizing selection on cis-regulatory genetic variation in humans. We analyze patterns of expression variation at copy number variants and find evidence for selection against large increases in gene expression. Using allele-specific expression (ASE) data, we further show evidence of selection against smaller-effect variants. We estimate that, across all genes, singletons in a sample of 122 individuals have ∼2.2× greater effects on expression variation than the average variant across allele frequencies. Despite their increased effect size relative to common variants, we estimate that singletons in the sample studied explain, on average, only 5% of the heritability of gene expression from cis-regulatory variants. Finally, we show that genes depleted for loss-of-function variants are also depleted for cis-eQTLs and have low levels of allelic imbalance, confirming tighter constraint on the expression levels of these genes. We conclude that constraint on gene expression is present, but has relatively weak effects on most cis-regulatory variants, thus permitting high levels of gene-regulatory genetic variation.
Loss of NFAT2 expression results in the acceleration of clonal evolution in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) can be defined as a clonal expansion of B cells with stereotypic BCRs. Somatic hypermutation of the BCR heavy chains (IGVH) defines a subgroup of patients with a better prognosis. In up to 10% of CLL cases, a transformation to an aggressive B cell lymphoma (Richter's syndrome) with a dismal prognosis can be observed over time. NFAT proteins are transcription factors originally identified in T cells, which also play an important role in B cells. The TCL1 transgenic mouse is a well‐accepted model of CLL. Upon B cell‐specific deletion of NFAT2, TCL1 transgenic mice develop a disease resembling human Richter's syndrome. Whereas TCL1 B cells exhibit tonic anergic BCR signaling characteristic of human CLL, loss of NFAT2 expression leads to readily activated BCRs indicating different BCR usage with altered downstream signaling. Here, we analyzed BCR usage in wild‐type and TCL1 transgenic mice with and without NFAT2 deletion employing conventional molecular biology techniques and next‐generation sequencing (NGS). We demonstrate that the loss of NFAT2 in CLL precipitates the selection of unmutated BCRs and the preferential usage of certain VDJ recombinations, which subsequently results in the accelerated development of oligoclonal disease.
School-based HIV/AIDS education, risky sexual behaviors, and HIV testing among high school students in the United States

ABSTRACT This study assessed the practical value of HIV/AIDS education among at-risk adolescents in the United States. Data were drawn from the 2013 Youth Risk Behavior Surveillance System spanning students in grades 9-12 who have engaged in sexual intercourse. A multivariate hierarchical logistic regression analysis was employed to test: (1) the individual effects of school-based HIV/AIDS education and risky sexual behaviors on the probability of HIV testing and (2) the interaction effects to estimate the degree to which the education effect varied by specific risky sexual behavior. The results indicated that students who engaged in risky sexual activities and received HIV/AIDS education were more likely to test for HIV compared to those who did not receive HIV/AIDS education. The relationship between education and HIV testing also varied according to the number of recent sexual partners. The findings have policy and practice implications. Specifically, HIV/AIDS education that promotes HIV testing should be encouraged particularly with the high-risk student population.
Risk of solid subsequent malignant neoplasms after childhood Hodgkin lymphoma—Identification of high‐risk populations to guide surveillance: A report from the Late Effects Study Group

Survivors of Hodgkin lymphoma (HL) in childhood have an increased risk of subsequent malignant neoplasms (SMNs). Herein, the authors extended the follow‐up of a previously reported Late Effects Study Group cohort and identified patients at highest risk for SMNs to create evidence for risk‐based screening recommendations.
Detecció i reconeixement de text mitjançant l'estimació de l'amplada del traç

This report presents a method for detecting and recognizing text in television pictures, which is based on estimating the stroke width. The method extracts the text that is present in the image, and writes it in a text file, so it can be used together with other features, for image indexing. This work on text detection and recognition for image indexing was developed in the context of the CENIT Buscamedia project. That is why, throughout the project, different versions of software were delivered to Televisio de Catalunya, which is one of the companies working with the project CENIT Buscamedia. A text detector has been developed, starting from a first implementation of the algorithm published by Microsoft Research paper, “Detecting text in natural scenes with stroke width transform”. Two new stages have been included, binarization and recognition. For the recognition we have used an open source software developed by Google, the Tesseract-OCR. Previously, a binarization stage was used to binarize the output of the text detector and facilitate the task of the OCR system. The results have improved considerably compared with the first version implemented, achieving a rate of 5.67% non-detected text versus 15.5% of the initial software. The quality factor has also been improved from an initial 39.03% to a 64.56%. Deteccio i reconeixement de text mitjancant l’estimacio de l’amplada del trac Index 1. Introduccio 1 2. Objectius del PFC 3 3. Estat de l’art 4 3.1. Metodes de deteccio de text en imatges 4 3.1. 1. Metodes basats en la segmentacio de la imatge 4 3.1. 2. Metodes basats en els contorns dels caracters 6 3.1. 3. Metodes basats en l’amplada del trac 8 3.2. Metode triat. 9 4. Algorisme 10 4.1. Descripcio general 10 4.2. Deteccio de text 12 4.2. 1. Deteccio de contorns 14 4.2. 2. SWT 15 4.2. 3. Creacio de les components 19 4.2. 4. Filtratge de components 21 4.2. 5. Creacio de les cadenes 25 4.2. 6. Analisis de les cadenes 30 4.3. Binaritzacio 32 4.3.1. Metode triat 32 4.4. Reconeixement de text 34 5. Avaluacio del sistema 36 5.1. Avaluacio segons els criteris ICDAR 36 5.1. 1. Resultats obtinguts: 39 5.2. Limitacions de l’algorisme 42 5.3. Comparacio de resultats entre algorisme inicial i final. 45 6. Conclusions 47 6.1. Treball futur 47 7. Referencies 50 Deteccio i reconeixement de text mitjancant l’estimacio de l’amplada del trac 1
Integrating Technology into Teacher Preparation and Practice: A Two-way Mentoring Model

This article reports on a pilot case study exploring the opportunity for authentic professional development in the use of technology. Self-selected pre-service and in- service teachers were paired so as to reinforce and enhance, firstly, their computer skill development and, secondly, their ability to integrate these same skills into classroom teaching practices. It was proposed that both groups of participants would derive benefit from these pairings. Results overwhelming support this and suggest (a) a model for better preparing teacher candidates to be able to integrate computer skills into classroom programming and (b) a new, perhaps more efficient, method of professional development for busy, dedicated classroom teachers.
Η γλώσσα των νεκρών

ΣΥΣΤΗΜΑΤΑ ΓΡΑΦΗΣ ΣΤΟ ΜEΣΟΓEΙΑΚΟ ΧΩΡΟ [ΠΑΝEΠΙΣΤΗΜΙΟ ΑΙΓΑΙΟΥ, ΣΧΟΛΗ ΑΝΘΡΩΠΙΣΤΙΚΩΝ EΠΙΣΤΗΜΩΝ, ΤΜΗΜΑ ΜEΣΟΓEΙΑΚΩΝ ΣΠΟΥΔΩΝ]
Epidemiologia hospitalaria del Epoc en un Hospital Militar. Lima, Perú

OBJETIVO Describir la dinamica epidemiologica de las hospitalizaciones por enfermedad obstructiva cronica (EPOC) en un hospital militar. MATERIAL Y METODO Estudio observacional retrospectivo de las hospitalizaciones por EPOC en un Hospital Militar nivel III-1 de Lima-Peru. El periodo analizado fue desde enero de 1991 a diciembre de 2013. Para el analisis de los datos se utilizo el software de STATA V12.1 y ms Excel 2013. RESULTADOS Se registraron 1350 egresos con EPOC lo que representa el 1.14% del total de egresos IC95% (0.10% - 1.20%); el 58.15% de los pacientes pertenecian al sexo masculino (p=0.001), el promedio de edad fue de 74 anos IC95% (73 - 75 anos), (P=0.001), el promedio de estancia hospitalaria fue de 11.3 dias IC95% (10.6 - 11.9 dias), (P=0.001). En relacion al tipo de pacientes segun su condicion en el hospital, el 31.41% fueron pacientes militares (424/1350) y representaron el 1.32% de todas las hospitalizaciones en esta poblacion. La letalidad por EPOC fue 3.93% IC95% (2.95% - 5.10%) siendo superior a nuestra tasa de mortalidad hospitalaria por todas las causas (2.81%) siendo estadisticamente significativo (p=0.012) odds ratio (OR) 1.4 IC95% (1.05 - 1.87). CONCLUSIONES El perfil epidemiologico de las hospitalizaciones por EPOC en nuestro hospital es la de un paciente del sexo varon con un promedio de edad superior a los 65 anos, quien permanecera en promedio 11 dias hospitalizados y donde el 3.93% de los mismo fallecera en dicha proceso de hospitalizacion. Observamos tambien que existe una laguna del conocimiento sobre la Epidemiologia hospitalaria del EPOC en nuestro pais; nuestro estudio contribuira a la generacion de este conocimiento. (Horiz Med 2014; 14(3): 33-36)
Funding Health Care: Options for Europe

Any books that you read, no matter how you got the sentences that have been read from the books, surely they will give you goodness. But, we will show you one of recommendation of the book that you need to read. This funding health care options for europe is what we surely mean. We will show you the reasonable reasons why you need to read this book. This book is a kind of precious book written by an experienced author.
Identification of potential miRNA-mRNA regulatory network and the key miRNAs in intramuscular and subcutaneous adipose

Intramuscular fat (IMF) is an important indicator for evaluating meat quality. Breeds with high IMF content are often accompanied by high subcutaneous fat (SCF), severely affecting the meat rate of pigs. Studying the mechanisms of miRNAs related to lipogenesis and lipid metabolism has important implications for pig breeding. We constructed two small RNA libraries from intramuscular and subcutaneous fat to evaluate the patterns of lipogenesis in Laiwu pig, a Chinese breed. A total of 286 differentially expressed miRNAs (DEmiRNAs), including 193 known miRNA and 93 novel miRNAs, were identified from two types of adipose. GO and KEGG enrichment analysis for DEmiRNAs showed that their target genes involved in many adipogenesis and lipid metabolism biological processes and signaling pathways, such as Wnt signaling pathway,MAPK signaling pathway, Hippo signaling pathway, PI3K-Akt signaling pathway, Melanogenesis, Signaling pathways regulating pluripotency of stem cells and so on. Then, we constructed a miRNA-mRNA interaction network to find out which miRNAs were the key miRNAs of regulation in Wnt signaling pathway. In this pathway, miR-331-3p, miR-339-5p, miR-874 and novel346_mature target PPARD, WNT10B, RSPO3, WNT2B. This study provides a theoretical basis for further understanding the post-transcriptional regulation mechanism of meat quality formation and predicting and treating diseases caused by ectopic fat.
Lean – Agile Software Development: Achieving Enterprise Agility

Reading is a hobby to open the knowledge windows. Besides, it can provide the inspiration and spirit to face this life. By this way, concomitant with the technology development, many companies serve the e-book or book in soft file. The system of this book of course will be much easier. No worry to forget bringing the lean agile software development achieving enterprise agility book. You can open the device and get the book by on-line.
Object-Oriented Systems Analysis and Design (2nd Edition)

Object Oriented Systems Analysis And Object-oriented (O-O) analysis and design is an approach that is intended to facilitate the development of systems that must change rapidly in response to dynamic business environments. Chapter 10 helps you understand what object-oriented systems analysis and design is, how it differs from the structured approach of the SDLC, and when it may be appropriate to use an object-oriented approach.
Dictionary of computers, information processing, and telecommunications

This is the only dictionary that links all three information technologies. This definitive reference source shows the relationship between them and makes their often confusing and intimidating vocabularies understandable to experts and laypersons alike. This edition has been extensively updated and expanded to reflect the tremendous advances in these areas since its publication in 1984. Its alphabetical format gives easy access to more than 10 000 listings, including new entries covering AI, integration, supercomputers, telecommunication and much more.
Protocolos para mejorar la performance de las aplicaciones Web

El protocolo HTTP ha sido revisado en un par de ocasiones, la última, ya hace más de una década. Sin embargo, las características de la Web actual, los requerimientos de sus usuarios, y los niveles de masividad hicieron que los recursos que se proveen mediante éste hayan alcanzado un punto donde se han encontrado algunas limitaciones inherentes al diseño original del protocolo. Es por ello que el IETF (Internet Engineering Task Force), dentro del HTTPbis Working Group, está analizando modificaciones, ajustes y/o mejoras de fondo en pos de alcanzar un futuro estándar HTTP 2.0.
Representing the meaning of discourse connectives for multilingual purposes.

Discourse connectives are lexical items indicating coherence relations between discourse segments. Even though many languages possess a whole range of connectives, important divergences exist cross-linguistically in the number of connectives that are used to express a given relation. For this reason, connectives are not easily paired with a univocal translation equivalent across languages. This paper is a first attempt to design a reliable method to annotate the meaning of discourse connectives cross-linguistically using corpus data. We present the methodological choices made to reach this aim and report three annotation experiments using the framework of the Penn Discourse Tree Bank.
Universal Design for Learning

Universal Design combines form and function to improve the experience for all users. Take this outdoor space as an example: People can use the gradual incline of the ramps, or they can use the stairs with or without railings. This space is accessible to a wide range of users – people who walk, use bicycles, strollers, or wheelchairs; people who prefer to hold a railing or people who would like to walk in a few different directions on their way up to the top. This outdoor space is a great example of how good design benefits everyone.
A multiplierless decimation filter for /spl Sigma//spl Delta/ A/D conversion

This paper describes the design of a FIR filter for decimation of signals coming from a multi-stage multi-bit /spl Sigma//spl Delta/ modulator. The FIR digital filter is based on a multi-stage design with multiplier-free implementation, employing shifters and accumulators to implement power-of-two multiplications. Moreover, the number of shift operations in the whole filter is minimised, and clock frequency is reduced in any stage according to the corresponding sampling rate, in order to reduce power consumption and to avoid performance degradation due to crosstalk. The resulting architecture reduces area and power requirements with respect to multiplier-based solutions. Experimental results on integrated prototypes confirm the filter functionality and the estimated power consumption.
Estudio de reactores Trickle-Bed : Aplicación al tratamiento de aguas contaminadas

El presente trabajo enfoca el estudio de Reactores Trickle-Bed (RTBs), tendiente a su aplicacion al tratamiento de aguas contaminadas. Se examina el efecto de la mojabilidad del relleno y de las caracteristicas espumantes del liquido sobre las transiciones de regimen de flujo pulsante-reptante en RTBs, analizando simultaneamente la capacidad de herramientas no convencionales para diagnosticar dichas transiciones. Estas se determinan por inspeccion visual y a partir del analisis de series temporales de fluctuaciones de presion, STFP, en el marco de las teorias estadistica convencional, de fractales temporales y de caos. Las STFP se miden en la pared de la columna, empleando aire y soluciones acuosas de un surfactante, como fluidos modelo, y lechos conformados por mezclas de particulas hidrofobicas e hidrofllicas en diferentes proporciones. Se encuentra que tanto la mojabilidad de las particulas como las caracteristicas espumantes del liquido influyen sobre las transiciones de flujo en RTBs. Por otra parte, se analizan los efectos de emplear un catalizador hidrofobico sobre la performance de RTBs, utilizando la oxidacion catalitica de etanol como reaccion modelo, a partir de ensayos en un equipo escala banco. Se determina la conversion de etanol en el RTB relleno con catalizador hidrofobico, hidrofilico y mezclas de diferentes proporciones de catalizador hidrofobico y soporte hidrofllico inerte. Los resultados se interpretan teniendo en cuenta factores hidrodinamicos y de transporte, mediante el planteo y la resolucion de un modelo matematico generalmente aceptado para describir el comportamiento de RTBs. Se encuentra que el empleo de catalizador hidrofobico, diluido o sin diluir, favorece significativamente la performance de RTBs para oxidaciones cataliticas.
Comet!: Une nouvelle gnration de !Widget! pour la Plasticit des Interfaces

A candle, lantern, or the like, having one or more light pipes. Reception faces of the light pipes gather light from the flame arena, and emission faces of the light pipes emit the gathered light at another location. The other location may be an exterior surface of the candle, or a decorative fixture. Multiple sets of light pipes may come into play at various times during the life of the candle. The reception faces may move as the candle burns, to stay in the flame arena.
Comparison of maximum pain intensity and duration of primary dysmenorrhea after acupressure on third liver and placebo points - A double-blind randomized controlled clinical trial

Background & Aim : Primary Dysmenorrhea (PD) is the most common genital disease among adults which can disrupt daily activities and reduce quality of life. Acupressure was recommended for relief of PD and the aim of this study was to compare the maximum pain intensity (MPI) and duration of PD after acupressure on third liver (LIV3) and placebo points. Methods & Materials : Students who were suffering from PD were studied for three menstrual cycles between March and June 2012. In the first cycle, intensity and duration of dysmenorrhea (DPD) were assessed and students with pain score≥4 according to visual analogue scale for MPI were selected. Randomized block allocation was performed based on pain intensity with 1:1 allocation ratio. Students, data analyzer and allocation were blind. Students applied acupressure themselves, on LIV3 or placebo points in the second and third cycles, only on first day of menstrual cycles in the beginning of bleeding. Acupressure was performed 4 times intermittently, (2 minutes pressure followed by 2 minutes rest, twice on each leg and 16 minutes in total). Chi-square, Mann –Whitney, Wilcoxon, Sign test and ordinal regression analysis were used. Results : In LIV3 group 27 and in control group 32 students were analyzed. MPI in each group decreased after intervention but decrease in DPD was not significant. There were not significant differences between groups based on ordinal regression test for MPI and DPD (p>0.05). Conclusion : Pressure at LIV3 point decreased MPI but was not significantly effective in reducing DPD. Further studies in more menstrual cycles and other techniques are recommended.
C programming language third edition

provides an Introduction to the C Programming Language. en.wikipedia. org /wiki/ Assembly Language Step-by-Step Programming with Linux, 3rd Edition H. Python programming for the absolute beginner, 3rd edition C programming for the and easy c programming guide (c programming, c programming language. Robert Seacord introduces the second edition of The CERT C Coding Standard: 98 Rules for Developing Safe, Programming LanguagesC, Third Edition.
Sftis: A Decision Support System for Tourism Demand Analysis and Forecasting

Accurate forecasts of tourism demand are prerequisite to the decision-making process in many organizations of the private or public sector. Any information concerning the future evolution of tourism flows is of great importance to hoteliers, tour operators and other industries related to tourism or transportation, in order to adjust their policy and corporate finance in an effective and efficient way. This paper aims to present a new, improved model for Tourism Demand Analysis and Forecasting (DTAF) and then to discuss the development of an innovative Decision Support System (called SFTIS) which provides the user with appropriate tools necessary for forecasting, analysis and effective use of tourism data, as a mean of decision support for optimal planning and policy making. In order to evaluate the system, we used Greek inbound tourism data for the year 2000 from ten major origin countries.
Budapest Open Access Initiativeの思想的背景とその受容

本稿ではオープンアクセス運動の契機となったBudapest Open Access Initiative（BOAI）について分析し，これがどのような意図のもとで公開されたか調査した．まず，BOAIを提唱し，オープンアクセス運動を支援している財団であるOpen Society Institute（OSI）と，その設立者であるGeorge Sorosについて紹介し，彼らの思想的根拠であるKarl R. Popperの提唱した「開かれた社会」概念について概観した．また，BOAI中にその思想が影響していることを明らかにした．次に，オープンアクセス運動に関連する文献群中でのPopperおよび「開かれた社会」への言及状況とBOAIの受容状況の定量的計測から，オープンアクセス関係者の間での「開かれた社会」関連思想の認知状況を検討した．その結果，OSIは「開かれた社会」という政治思想の実現を目的にオープンアクセス運動に関与しているにもかかわらず，他のオープンアクセス運動関係者はこの思想の存在には言及していないことがあきらかになった．
The American Sign Language Handshape Dictionary

Now, students and others interested in learning American Sign Language (ASL) can look up specific signs without needing to know their meaning in English beforehand. The American Sign Language Handshape Dictionary can help users locate a sign whose meaning they have forgotten, or help them find the meaning of a new sign they have just seen for the first time. Instead of offering a conventional alphabetical arrangement of English words and their corresponding signs, The ASL Handshape Dictionary organizes more than 1,600 ASL signs by 40 basic handshapes and includes detailed descriptions on how to form each sign. In easy-to-follow style, The ASL Handshape Dictionary explains how signs are used in ASL structure and presents clear, explicit directions on how to identify a sign and its meaning in the specific context of its use. A complete English word index provides the option of referring to an alphabetical listing of English terms to locate an equivalent sign or choice of signs.
Characterizing novice compilation behavior

1.1 Motivation . 31.1. 1 Folk wisdom . 31.1. 2 History . 41.1. 3 Literature . 41.2 The Project . 51.3 Structure of the prospectus . 6