Miracle-dz/UniFAR-FTUs huggingface dataset:
Analyzing Consumer Attitude Toward Mobile Payment Technology and Its Role in Booming the E-Commerce Business

This study analyses factors which affect consumer attitudes and their decision to use the m-payment “mobile payment” technology. A total of 670 respondents were featured in the survey, which analyzed “mobile payment” technology in the Saudi Arabia, and the partial least squares structural equation model was used to analyze the data. The findings indicated that the ease of use and usefulness of m-payment technology in terms of influencing attitude for consumers. Security was viewed to have less effect on attitude and the usage of m-technology. On the other hand, social influences did not have a significant effect on the users of m-technology.
Reconnoitering the association between body mass index and oral health among elementary school children in Hyderabad, Telangana, India

Objective: To evaluate the association between body mass index (BMI) and oral health status among elementary school children in Hyderabad, Telangana, India. Materials and Methods: This cross-sectional study was conducted among elementary school children selected from government, private-aided and private-unaided schools in Hyderabad. A stratified cluster random sampling technique was used to select study participants. All parents were requested to be personally present on the day of examination. All eligible children were assembled in a hall and their height in inches and weight in kilograms were recorded by two calibrated investigators. The oral health status of children was assessed using a predesigned oral health assessment proforma. Plaque status was assessed using Sillness and Loe plaque Index and caries using decayed and filled teeth (dft) by a trained and calibrated investigator. Results: One hundred and seventy-one children (89 males and 82 females) were included in the present study. Mean plaque score was 1.4 ± 0.6 with no significant difference in the mean plaque score between children in three different categories of nutritional status (P = 0.07). Mean dft among primary teeth was 1.1 ± 1.1 with a significantly higher score among children who were malnourished (2.4 ± 0.9) compared to children who were overweight (0.9 ± 0.9) and normal (0.4 ± 0.6) (P < 0.001). Conclusion: BMI was negatively associated with caries experience in primary dentition with no association with plaque scores. Overweight children with malnutrition had significantly higher caries experience compared to children with normal BMI.
HIV Testing and Sexual Health Among Black African Men and Women in London, United Kingdom

Key Points Question What proportion of black African adults attending social and commercial venues in London, United Kingdom, have been tested for HIV in the past 5 years and what proportion are living with HIV—both diagnosed and undiagnosed? Findings In this cross-sectional study of 604 respondents, 51.0% of men and 52.7% of women had undergone HIV testing in the past 5 years. Of respondents who provided an oral fluid sample for anonymized HIV testing, 93.2% of women and 90.4% of men were HIV negative; among those testing positive, 56.3% of women and 40.9% of men self-reported as HIV negative or untested, indicating they were living with undiagnosed HIV. Meaning Despite ongoing campaigns to increase HIV testing in African communities in London, the fraction living with undiagnosed HIV remains unacceptably high; therefore, testing coverage must be enhanced to meet the HIV prevention needs of this group.
Beyond the Flavour: The Potential Druggability of Chemosensory G Protein-Coupled Receptors

G protein-coupled receptors (GPCRs) belong to the largest class of drug targets. Approximately half of the members of the human GPCR superfamily are chemosensory receptors, including odorant receptors (ORs), trace amine-associated receptors (TAARs), bitter taste receptors (TAS2Rs), sweet and umami taste receptors (TAS1Rs). Interestingly, these chemosensory GPCRs (csGPCRs) are expressed in several tissues of the body where they are supposed to play a role in biological functions other than chemosensation. Despite their abundance and physiological/pathological relevance, the druggability of csGPCRs has been suggested but not fully characterized. Here, we aim to explore the potential of targeting csGPCRs to treat diseases by reviewing the current knowledge of csGPCRs expressed throughout the body and by analysing the chemical space and the drug-likeness of flavour molecules.
Establishment of a zebrafish hematological disease model induced by 1,4-benzoquinone

ABSTRACT Benzene exposure is associated with various hematological disorders, in particular leukemia. The reactive metabolite of benzene, 1,4-benzoquinone (BQ), generated in bone marrow, is suggested to be a key molecule in mediating benzene-induced hematotoxicity and carcinogenicity. However, its pathogenic role remains largely unknown due to a lack of suitable vertebrate whole-organism models. Here, we present an in vivo study to reveal the effect of BQ exposure on hematotoxicity in zebrafish. From embryonic stages to adulthood, BQ exposure suppressed erythroid and lymphoid hematopoiesis but led to abnormal accumulation of myeloid cells and precursors, which resembles benzene-induced cytopenia and myeloid dysplasia in humans. This myeloid expansion is caused by granulocyte, but not macrophage, lineage, emphasizing the significant role of lineage specificity in BQ-mediated hematopoietic toxicity. Analysis of the c-myb (also known as myb)-deficient mutant cmybhkz3 revealed that BQ induced neutrophilia in a c-myb-dependent manner, demonstrating that c-myb is a key intrinsic mediator of BQ hematotoxicity. Our study reveals that BQ causes lineage-specific hematotoxicity in zebrafish from embryonic stages to adulthood. Since c-myb is indispensable for BQ to induce neutrophilia, c-myb could serve as a potential drug target for reversing BQ hematotoxicity. Summary: Acute exposure to 1,4-benzoquinone leads to lineage-specific hematotoxicity in zebrafish from embryonic stages to adulthood, resembling benzene-induced cytopenia and myeloid dysplasia in humans.
Suppression of ILC2 differentiation from committed T cell precursors by E protein transcription factors

Current models propose that group 2 innate lymphoid cells (ILC2s) are generated in the bone marrow. Here, we demonstrate that subsets of these cells can differentiate from multipotent progenitors and committed T cell precursors in the thymus, both in vivo and in vitro. These thymic ILC2s exit the thymus, circulate in the blood, and home to peripheral tissues. Ablation of E protein transcription factors greatly promotes the ILC fate while impairing B and T cell development. Consistently, a transcriptional network centered on the ZBTB16 transcription factor and IL-4 signaling pathway is highly up-regulated due to E protein deficiency. Our results show that ILC2 can still arise from what are normally considered to be committed T cell precursors, and that this alternative cell fate is restrained by high levels of E protein activity in these cells. Thymus-derived lung ILC2s of E protein–deficient mice show different transcriptomes, proliferative properties, and cytokine responses from wild-type counterparts, suggesting potentially distinct functions.
Metabolic Profiling of Pitaya (Hylocereus polyrhizus) during Fruit Development and Maturation

Pitaya (Hylocereus polyrhizus) has attracted much interest from consumers as it is a novelty fruit with high nutrient content and a tolerance to drought stress. As a group of attractive pigment- and health-promoting natural compounds, betalains represent a visual feature for pitaya fruit quality. However, little information on the correlation between betalains and relevant metabolites exists so far. Currently, color (Commission International del’Eclairage, CIE) parameters, betalain contents, and untargeted metabolic profiling (gas chromatography-time-of-flight-mass spectrometry, GC–MS and liquid chromatography tandem mass spectrometry, LC–MS) have been examined on ‘Zihonglong’ fruits at nine different developmental stages, and the variation character of the metabolite contents was simultaneously investigated between peel and pulp. Furthermore, principal component analysis (PCA) and partial least-squares discriminant analysis (PLS-DA) were used to explore metabolite profiles from the fruit samples. Our results demonstrated that the decrease of amino acid, accompanied by the increase of sugars and organic acid, might contribute to the formation of betalains. Notably, as one of four potential biomarker metabolites, citramalic acid might be related to betalain formation.
Direct cell imprint lithography in superconductive carbon black polymer composites: process optimization, characterization and in vitro toxicity analysis

Cell imprint lithography (CIL) or cell replication plays a vital role in fields like biomimetic smart culture substrates, bone tissue engineering, cell guiding, cell adhesion, tissue engineering, cell microenvironments, tissue microenvironments, cell research, drug delivery, diagnostics, therapeutics and many other applications. Herein we report a new formulation of superconductive carbon black photopolymer composite and its characterization towards a CIL process technique. In this article, we demonstrated an approach of using a carbon nanoparticle-polymer composite (CPC) for patterning cells. It is observed that a 0.3 wt % load of carbon nanoparticles (CNPs) in a carbon polymer mixture (CPM) was optimal for cell-imprint replica fabrication. The electrical resistance of the 3-CPC (0.3 wt %) was reduced by 68% when compared to N-CPC (0 wt %). This method successfully replicated the single cell with sub-organelle scale. The shape of microvesicles, grooves, pores, blebs or microvilli on the cellular surface was patterned clearly. This technique delivers a free-standing cell feature substrate. In vitro evaluation of the polymer demonstrated it as an ideal candidate for biomimetic biomaterial applications. This approach also finds its application in study based on morphology, especially for drug delivery applications and for investigations based on molecular pathways.
Prediction of Inbound & Domestic Takeover Candidates from Indian Market - Pre and Post Global Crisis

M&As are the key drivers for economic growth in developing countries, specifically with respect to India. In the view of proliferating inbound acquisitions and thereby enhancing the FDI of the country, many governmental policies are also implemented. Though a substantial literature is available towards various aspects of M&As in developed countries, only a very few works deal with respect to developing countries and further only a very minimal research is done with special attention to India. Again, there has been very limited amount of work in the context of predicting inbound target determinants, separately from that of the domestic target determinants. Further, models built and inferences drawn for developed countries vary with that of India, thereby adding more emphasis on studying M&A with specific attention to India. Moreover, the global financial crisis has had a great impact on all the nations with India being no exception. The global crisis has taught many financial lessons to firms of all sectors. Hence, there is a necessity to analyse if there is any change in the determinants of targets pre- and post-crisis. This work focuses on predicting the inbound takeover targets in India through logistic regression models on 527 Indian target firms over the period of 2005-2015. The time frame chosen for the groundwork also comprises Global Financial Crisis, which is one of the most significant financial events in the history of world economics. Thus, this work also provides an analysis of impact of this event considering an emerging market like India. The outcomes reveal that firms dealing with feasible products, excellent networking and distribution, huge assets with low cash in hand have the high probability of being predicted as inbound targets. On the contrary, firms with high public shareholdings and that involve in the production of superior products when compared to that of their peers yet find it difficult to make profit are preferred as targets by the domestic acquirers. It has been interesting to note that the financial crisis did not have any significant impact with respect to the determinants of the inbound and domestic targets in Indian context. The outcomes provide significant insights to various stakeholders such as acquirers, the targets themselves, investment bankers and the policy makers involved in M&A. Keywords: Logistic Regression, Inbound Acquisition, Domestic Acquisition, Target firms, M&A in India, Non-Target firms.
Golimumab for Rheumatoid Arthritis

Since the advent of infliximab for the treatment of rheumatoid arthritis (RA), new genetically-engineered molecules have appeared. This review aims to present the current data and body of evidence for golimumab (GLM). Safety, efficacy, tolerability and immunogenicity are all being investigated, not only through phase III trials (GO-BEFORE, GO-FORWARD, GO-AFTER, GO-MORE, GO-FURTHER, GO-NICE), but also through studies of real-world data. It seems that GLM in the subcutaneous form is an efficacious molecule with a good safety profile at the standard dosage scheme, but a 100 mg subcutaneous dose is associated with a higher risk of opportunistic infections, lymphoma and demyelination. Furthermore, when compared to other tumor necrosis factor-α molecules, it is non-inferior, and, at some points, such as when it comes to immunogenicity and persistence of the drug, it has a better profile. In summary, GLM is an effective, well-tolerated option for the treatment of RA, for both the clinician and patients who are seeking a convenient dosage scheme.
Sexuality in premature ovarian insufficiency

Abstract Sexuality in women with spontaneous premature ovarian insufficiency (POI) deserves attention because of the young age and the distressing impact of such a life-changing diagnosis. Biomedical and psychosocial factors work in concert to determine significant changes of sexual function. Early hormonal deprivation gives origin to symptomatic vulvovaginal atrophy and contributes to hypoactive sexual desire disorder modulating central and peripheral circuitries, which regulate sexual response. Emotional and cognitive adjustment to the short-term and long-term consequences of POI may further determine negative attitudes toward sexuality. It is essential to counsel POI women on every aspect of their life, from menopausal symptoms to fertility concerns, from health risks to potential therapeutic solutions. The biopsychosocial perspective is the best approach to manage sexual symptoms, including tailored hormone therapy and focused counseling. Pharmacotherapies specifically investigated in spontaneous POI conditions are lacking and clinical judgment has to guide the choice of treatment, which must be continued at least until the average age at natural menopause according to the most recent guidelines. Further studies are needed to better characterize POI women and to understand the effective role of novel therapeutic strategies, including androgens and cognitive-behavioral and sexual interventions.
Syllable Structure of Pakistani English in Phonological Theory

This article describes the syllable of Pakistani English (PE. It compares the syllable of PE with British English, in the light of concepts of syllabic (Chomsky and Halle, 1968), syllabification, template, syllable pattern, model of syllable structure, phonotactics and syllable weight. In the end, the following differences in syllabic phonology of PE and British English are summarized: In phonotactic constraints, one difference is found that is in the syllable of PE cluster of three consonants i.e. /s/, /p or t or k/, /l or r/ is allowed only in monosyllabic words, whereas word internally this cluster is not permissible. So, [ek.sklIUd] becomes [eks.klIUd] in PE; the weight of the syllable in PE is not only based on the quality of vowel but also the quality of consonant; in PE every syllable must contain vowel as a nucleus.
THE EFFECT OF OSSEODENSIFICATION TECHNIQUE ON IMPLANT STABILITY (CLINICAL TRIAL)

Introduction: Dental implants primary or initial stability originates from the engagement with the cortical bone mechanically, whereas the secondary stability signifies the stability biologically by means of osseointegration through the bone formation and remodeling from the cancellous bone. Osseodensification is an innovative biomechanical technique to prepare the site. It uses Densifying Burs to produce low plastic deformation owing to its non-removal densifying method of site preparation, which preserves the bone enhancing the host site. Objectives: To evaluate the osseodensification (OD) technique used in implant site preparation by using the newly designed burs (Densah burs), and its effect on enhancing implant primary and secondary stability. Material and Methods: Twenty dental implants were placed in ten patients; each patient received one implant using the new Osseodensification drilling technique and one implant using the conventional drilling technique in the posterior maxillary ridge. Osstell was used in measuring resonance frequency (ISQ-scale) which is used to determine the amount of implant stability. Results: The results showed a significant improvement in both primary and secondary stability using densah burs. Conclusions: Densah burs produce better bone quality around the implant than conventional drills, and therefore, there is an improvement in the primary and secondary stability.
Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study

Background Cardiovascular disease and chronic kidney disease share several common risk factors. The Framingham risk score is hypothesized to predict chronic kidney disease development. We determined if the Framingham risk scoring system can correctly predict incident chronic kidney disease in the general population. Methods This study included 9,080 subjects who participated in the Korean Genome and Epidemiology Study between 2001 and 2014 and had normal renal function. The subjects were classified into low- (< 10%), intermediate- (10–20%), and high- (> 20%) risk groups based on baseline Framingham risk scores. The primary endpoint was de novo chronic kidney disease development (estimated glomerular filtration rate [eGFR], < 60 mL/min/1.73 m2). Results During a mean follow-up duration of 8.9 ± 4.3 years, 312 (5.3%), 217 (10.8%), and 205 (16.9%) subjects developed chronic kidney disease in the low, intermediate, and high risk groups, respectively (P < 0.001). Multivariable analysis after adjustment for confounding factors showed the hazard ratios for the high- and intermediate risk groups were 2.674 (95% confidence interval [CI], 2.197–3.255) and 1.734 (95% CI, 1.447–2.078), respectively. This association was consistently observed irrespective of proteinuria, age, sex, obesity, or hypertension. The predictive power of this scoring system was lower than that of renal parameters, such as eGFR and proteinuria, but increased when both were included in the prediction model. Conclusion The Framingham risk score predicted incident chronic kidney disease and enhanced risk stratification in conjunction with traditional renal parameters in the general population with normal renal function.
The antagonistic effect of UV radiation on warming or nitrate enrichment depends on ecotypes of freshwater macroalgae (Charophytes)

Increases in ultraviolet radiation (UVR), a negative global change factor, affect aquatic primary producers. This effect is expected to be modulated by other global change factors, and to be different for populations adapted to different environments. A common garden experimental approach using freshwater green macroalgae, the cosmopolitan charophyte species Chara hispida and C. vulgaris, allowed us to test whether the beneficial increases in water temperature (T) and nitrate concentration (N) mitigate negative UVR effects. Also, whether these interactions would be not only species–specific but also according to the origin of the population; therefore, two populations of each species were used: one from a coastal wetland and the other from a mountain lake. Two factorial‐design experiments were performed: (i) the presence and absence of UVR × lower and higher T × four populations, and (ii) the presence and absence of UVR × lower and higher N × four populations. Response variables were: growth, morphometry, UVR‐protective compounds, photosynthetic pigments, and stoichiometric composition. There were consistent response patterns in the key variables that represent different organization levels. Our main results showed that both warming and, to a lesser extent, the increase in nutrients ameliorated the negative effects of UVR on the molecular processes involved in acclimation to UVR, and that such a mitigating effect depended on the different phenotypic plasticity of each species and each ecotype. The coastal populations, being from a more variable environment, were more resilient than the mountain populations, mainly because of changes in growth and morphology.
Toward an Ethically Founded Framework for the Use of Mobile Phone Call Detail Records in Health Research

Data derived from the plethora of networked digital devices hold great potential for public benefit. Among these, mobile phone call detail records (CDRs) present novel opportunities for research and are being used in a variety of health geography studies. Research suggests that the public is amenable to the use of anonymized CDRs for research; however, further work is needed to show that such data can be used appropriately. This study works toward an ethically founded data governance framework with social acceptability. Using a multifaceted approach, this study draws upon data governance arrangements in published health research using CDRs, with a consideration of public views and the public’s information expectations from mobile network operators, and data use scenarios of CDRs in health research. The findings were considered against a backdrop of legislative and regulatory requirements. CDRs can be used at various levels of data and geographic granularity and may be integrated with additional, publicly available or restricted datasets. As such, there may be a significant risk of identity disclosure, which must be mitigated with proportionate control measures. An indicative relative risk of the disclosure model is proposed to aid this process. Subsequently, a set of recommendations is presented, including the need for greater transparency, accountability, and incorporation of public views for social acceptability. This study addresses the need for greater clarity and consistency in data governance for CDRs in health research. While recognizing the need to protect commercial interests, we propose that these recommendations be used to contribute toward an ethically founded practical framework to promote the safe, socially acceptable use of CDR data for public benefit. This pattern needs to be repeated for the appropriate use of new and emerging data types from other networking devices and the wider internet of things.