Miracle-dz/UniFAR-FTUs huggingface dataset:
Determination of proximity to static voltage collapse using CPF-GMRES method

Voltage collapse is an event that causes major concern to the power system utility nowadays. The effect can be catastrophic to the power system where it can cause total collapse to the operation of the system. The study of the voltage collapse phenomenon can provide a way to prevent this event from happening. There have been many methods developed to study the criteria of voltage collapse phenomenon but static analysis probably provide the best way to study this phenomenon. Conventional Newton Raphson method has the singularity problem on its Jacobian matrix and thus could not give the solution. To overcome this problem, one of the solutions is the continuation power flow (CPF) method. CPF method is a very powerful method that can give the solution without having the singularity problem. The key to the CPF method is through the predictor and corrector technique used. This paper focuses on improvement of the time taken by the CPF method by enforcing the general minimal residual (GMRES) method at the initial point at the start up. The robustness of the standard CPF method is also improved using the new CPF-GMRES method. The convergence properties of this new method will be analysed and compared with the standard CPF method.
Tubulo-squamous polyp with mucinous and goblet cell differentiation: a unique morphologic variant.

To the Editor: We read with great interest the report by Chaturevedi and Padel (1) of a case of tubulo-squamous polyp (TSP) of the vagina with sebaceous glands. Recently, we diagnosed a TSP that was unique because of the presence of prominent mucinous and goblet cell differentiation, a variant not previously described. A 36-year-old woman undergoing tubal ligation was found to have a vaginal polyp on examination, which was excised. The polyp measured 1.3 cm in its
Natural Fatal Sarcocystis Falcatula Infections in Free-Ranging Eagles in North America

Three bald eagles (Haliaeetus leucocephalus) and 1 golden eagle (Aquila chrysaetos) were admitted to rehabilitation facilities with emaciation, lethargy, and an inability to fly. Intravascular schizonts and merozoites were present in 2 bald eagles, mainly in the lung tissue, whereas the third bald eagle and the golden eagle had lymphohistiocytic encephalitis with intralesional schizonts and merozoites. In all eagles, protozoal tissue cysts were present in skeletal musculature or heart. The protozoal organisms were morphologically compatible with a Sarcocystis sp. By immunohistochemistry, the protozoal merozoites were positive for Sarcocystis falcatula antigen in all cases when using polyclonal antisera. Furthermore, the protozoa were confirmed to be most similar to S. falcatula by polymerase chain reaction in 3 of the 4 cases. To the authors' knowledge, this report presents the first cases of natural infection in eagles with S. falcatula as a cause of mortality.
n vivo diabetic wound healing effect and HPLC – DAD – ESI – MS / MS rofiling of the methanol extracts of eight Aloe species beer

Genus Aloe, Xanthorrhoeaceae, is well distributed all over Egypt, and many species have been used as medicinal plants; mainly reported to prevent cardiovascular diseases, cancer and diabetes. This study attempts to analyze the secondary metabolites in the methanol extract of the leaves of eight Aloe species; A. vera (L.) Burm. f. , A. arborescens Mill. , A. eru A. Berger, A. grandidentata Salm-Dyck, A. perfoliata L. , A. brevifolia Mill. , A. saponaria Haw. and A. ferox Mill. growing in Egypt. For this aim HPLC–DAD–MS/MS in negative ion mode was used. Although belonging to the same genus, the composition of each species presented different particularities. Seventy one compounds were identified in the investigated Aloe species, of which cis-p-coumaric acid derivaties, 3,4-O-(E) caffeoylferuloylquinic acid and caffeoyl quinic acid hexoside were the most common phenolic acids identified. Aloeresin E and isoaloeresin D, 2′-O-feruloylaloesin were the common anthraquinones identified. Lucenin II, vicenin II, and orientin were the common identified flavonoids in the investigated Aloe species. 6′-Malonylnataloin, aloe-emodin-8-O-glucoside, flavone-6,8-di-C-glucosides could be considered as chemotaxonomic markers for the investigated Aloe species. The eight Aloe species had significant anti-inflammatory activity, in addition to the significant acceleration of diabetic wound healing in rats following topical application of the methanol extracts of their leaves. This is the first simultaneous characterization and qualitative determination of multiple phenolic compounds in Aloe species from locally grown cultivars in Egypt using HPLC–DAD–MS/MS, which can be applied to standardize the quality of different Aloe species and the future design of nutraceuticals and cosmetic preparations. rasil he CC © 2016 Sociedade B access article under t
Enhanced phenacetin metabolism in human subjects fed charcoal‐broiled beef

There were marked individual differences in the plasma levels of phenacetin after oral administration of a 900‐mg dose to 9 normal volunteers eating their customary home diet. Feeding a diet that contained charcoal‐broiled beeffor 4 days prior to the administration of phenacetin markedly decreased the plasma levels of this drug without appreciably influencing the plasma concentrations of phenacetin's metabolite, N‐acetyl‐p‐aminophenol (APAP), or the plasma half‐life of phenacetin. The average peak concentration of phenacetin in plasma, after a 900‐mg oral dose, fell from 1,628 ng/ml, when the subjects were fed a control diet for 7 days, to 352 ng/ml after they were fed the same diet which contained charcoal‐broiled beeffor 4 days. The average peak concentration of phenacetin rose to 1,885 ng Iml after the subjects were subsequently fed the control diet for 7 days. The ratios of the average concentrations of APAP in plasma to those of phenacetin markedly increased after the charcoal‐broiled beef diet. The results suggest that a diet containing charcoal‐broiled beef enhances the metabolism of phenacetin in the gastrointestinal tract and/or during its first pass through the liver. This effect greatly decreases the bioavailability of phenacetin.
Microwave-Induced Synthesis of Schiff Bases of Aminothiazolyl Bromocoumarins as Antibacterials

A fast and highly efficient method for the synthesis of some of the schiff bases of aminothiazolylbromocoumarin (4a-m) has been performed by microwave irradiation of 2′-amino-4′-(6-bromo-3-coumarinyl) thiazole (3) and substituted aromatic aldehydes (a-m). Microwave assisted reactions have resulted in better yields of the desired products than when prepared under conventional conditions. The resulting products were evaluated for their qualitative and quantitative antibacterial activity.
A prospective examination of Axis I psychiatric disorders in the first 5 years following moderate to severe traumatic brain injury

Background Psychiatric disorders commonly emerge during the first year following traumatic brain injury (TBI). However, it is not clear whether these disorders soon remit or persist for long periods post-injury. This study aimed to examine, prospectively: (1) the frequency, (2) patterns of co-morbidity, (3) trajectory, and (4) risk factors for psychiatric disorders during the first 5 years following TBI. Method Participants were 161 individuals (78.3% male) with moderate (31.2%) or severe (68.8%) TBI. Psychiatric disorders were diagnosed using the Structured Clinical Interview for DSM-IV, administered soon after injury and 3, 6 and 12 months, and 2, 3, 4 and 5 years post-injury. Disorder frequencies and generalized estimating equations were used to identify temporal relationships and risk factors. Results In the first 5 years post-injury, 75.2% received a psychiatric diagnosis, commonly emerging within the first year (77.7%). Anxiety, mood and substance-use disorders were the most common diagnostic classes, often presenting co-morbidly. Many (56.5%) experienced a novel diagnostic class not present prior to injury. Disorder frequency ranged between 61.8 and 35.6% over time, decreasing by 27% [odds ratio (OR) 0.73, 95% confidence interval (CI) 0.65–0.83] with each year post-injury. Anxiety disorders declined significantly over time (OR 0.73, 95% CI 0.63–0.84), whilst mood and substance-use disorder rates remained stable. The strongest predictors of post-injury disorder were pre-injury disorder (OR 2.44, 95% CI 1.41–4.25) and accident-related limb injury (OR 1.78, 95% CI 1.03–3.07). Conclusions Findings suggest the first year post-injury is a critical period for the emergence of psychiatric disorders. Disorder frequency declines thereafter, with anxiety disorders showing greater resolution than mood and substance-use disorders.
Contrast sensitivity loss is coupled with capillary dropout in patients with diabetes.

PURPOSE To assess the relationship of foveal microcirculation to contrast sensitivity function in early diabetes mellitus. METHODS Twenty patients with diabetes with visual acuity of 20/25 or better without clinically significant macular edema were evaluated. Measurements of contrast sensitivity at four spatial frequencies (3, 6, 12, and 18 cycles/degree [c/deg]), macular capillary blood velocity (CBV), capillary density (PIA: perifoveal intercapillary area), foveal avascular zone (FAZ), and microaneurysm count were performed. Contrast sensitivity data collected from age-matched normal subjects and previously published normal angiographic data were used for comparison with our cohort with diabetes. RESULTS The CBV was significantly reduced (P < 0.0001) and PIA and FAZ were significantly enlarged (P < 0.0001) when compared with healthy subjects. Contrast sensitivity was significantly lower in the group with diabetes at 6 (P = 0.01) and 12 (P = 0.002) c/deg as compared with healthy control values. FAZ and PIA correlated significantly (FAZ; r = -0.60, P = 0.005; PIA; r = -0.54, P = 0.02) with contrast sensitivity at 12 c/deg. CONCLUSIONS The alterations of the perifoveal network are related to selective disturbances of central visual function as measured by contrast sensitivity. In patients with diabetes measurement of contrast sensitivity may provide a clinical adjunct in further identifying early ischemic diabetic maculopathy.
Parkinson's disease: Levodopa‐induced dyskinesia and signal transduction

l‐3,4‐Dihydroxyphenylalanine (l‐dopa) remains the most effective pharmacological treatment for relief of the severe motor impairments of Parkinson’s disease. It is very effective in controlling parkinsonian symptoms in the initial phase of the disease, but its action wanes with time. Such ‘wearing‐off’ imposes an escalation in the dosage of the drug, which ultimately fails to provide stable control of motor symptoms and results in the appearance of abnormal involuntary movements or dyskinesia. ‘Peak‐dose’l‐dopa‐induced dyskinesia (LID) currently represents one of the major challenges in the treatment of Parkinson’s disease. Accumulating evidence suggests that LID derives from overstimulation of dopamine receptors located on the GABAergic medium spiny neurons (MSNs) of the dorsal striatum. These neurons form two distinct projection pathways, which exert opposite effects on motor activity: the direct, striatonigral pathway promotes locomotion, whereas the indirect, striatopallidal pathway depresses locomotion. In order to understand the mechanisms underlying LID, it is important to identify molecular adaptations produced by chronic administration of l‐dopa, at the level of one or the other of these two neuronal populations. This review summarizes the results of recent studies indicating that LID is associated with abnormal dopamine D1 receptor signaling affecting the MSNs of the direct pathway. The role of this pathological adaptation and of the consequent changes in signaling in the development and expression of LID are discussed.
Draft Genome Sequences of Four Nosocomial Methicillin-Resistant Staphylococcus aureus (MRSA) Strains (PPUKM-261-2009, PPUKM-332-2009, PPUKM-377-2009, and PPUKM-775-2009) Representative of Dominant MRSA Pulsotypes Circulating in a Malaysian University Teaching Hospital

ABSTRACT Here, we report the draft genome sequences of four nosocomial methicillin-resistant Staphylococcus aureus strains (PPUKM-261-2009, PPUKM-332-2009, PPUKM-377-2009, and PPUKM-775-2009) isolated from a university teaching hospital in Malaysia. Three of the strains belong to sequence type 239 (ST239), which has been associated with sustained hospital epidemics worldwide.
Decision Support Under Uncertainty Using Exploratory Multisimulation with Multiresolution Multistage Models

Abstract : In most realistic simulation-supported decision making situations, the nature of the problem changes as the simulation unfolds. Initial parameters, as well as models, can be irrelevant under emergent conditions. Furthermore, our knowledge about the problem being study may not be captured by any single model or experiment. Therefore, adaptively in simulations and scenarios is necessary to deal with emergent conditions and for evolving systems in a flexible manner. Dealing with uncertainty is paramount to analyzing complex evolving phenomena. This effort involved (1) a new advanced simulation methodology, called exploratory multisimulation to promote problem space exploration, as opposed to traditional solution space exploration concept to deal with challenges pertaining to irregular and asymmetric warfare and (2) a symbiotic multisimulation-based decision support system based on the Naturalistic Decision Making paradigm. The decision support system illustrates how situational awareness can be enhanced by intelligent agents with perception, understanding, and anticipation capabilities to support multisimulation-based exploration of this problem area.
Avicenna Aspect of Cardiac Risk Factors

Dear Editor-in-ChiefDuring the last decade, the term " Acute risk factors" was used commonly to describe some activities and events which increase the risk of acute cardiac diseases (1) include: meteorologi- cal stress (2, 3), emotional stress (1, 3), overeat- ing (1, 3), nicotine abuse (2), different tensity of physical activity (3), especially heavy physical activity(l,3), sexual activity (1,3), during sleep (2), cold or heat exposure (1), coffee or alcohol consumption (1), and cocaine or marijuana use (1). There are some studies which have directly or indirectly studied cardiac risk factors accord- ing to gender (4-6), blood group (7) and even among unhealthy people such as patients with metabolic syndrome (8,9). Avicenna, ancient Iranian scientist (980 - 1037 AD) in third book of his masterpiece, the Ca- non of Medicine, has described heart diseases. According to his teaching, heart is the source of innate heat and is considered as a chief or- gan in body; factors which destroy innate heat may result in heart weakness and then heart diseases (10). In the first book of Canon, Avicenna said that there are some causes which may make innate heat weak through different mechanisms in- clude: Overindulgence in exercise, sleepless- ness, emotional stress, prolonged persistence in bath specially too warm bath, excessive defeca- tion of humors and fluids from body through severe diarrhea and/or bleeding, overeating and drinking, overindulgence in sexual activity, puffy body morphology, emotional states such as too preoccupation, too sadness, too exhilaration, and too pleasure, everything change body temperament such as some drugs, warm weath- er, inhaling rotten air or poisonous air, pain specially in stomach, fever, excessive perspi- ration, severe starvation. The weakness of the heart, sometimes other organs play a role; for example, diseases in some organs such as pleura, meninge, lung, liver, and specially stomach, may result in heart weakness (9). Of course, four factors are more important than others include: exercise overdoing, emotional stress, overdoing of sexual activity and sleeplessness (11, 12). As a conclusion, Avicenna never used the term "Acute risk factors" or "External triggers" but he explained nearly twenty factors that may change normal status of heart some of which are very similar to external triggers of acute myocardial infarction. More studies about heart enfeebler factors according to Avicenna's view, is recommended. [Reference]References1. Culic Y (2007). Acute risk factors for myocar- dial infarction. …
Development of a P300 Brain–Machine Interface and Design of an Elastic Mechanism for a Rehabilitation Robot

This paper focuses on the development of a P300 speller and the design of a rehabilitation robot using a brain-machine interface. The combined feature set provides a norm that can be used to assess trends of the user’s increased or decreased independence. The combined feature set is found to maintain a 90% sorting rate; it can also reduce the relationship of individual independence for each subject. Among the results, the highest P300 classification accuracy can be increased by 36.04%. A novel adaptive coupled elastic actuator (ACEA) is proposed that uses adjustable characteristics to adapt to the applied output and input forces, thus ensuring safe human-machine interaction without the use of complex control strategies. The proposed robotic system uses variable impedance to achieve adaptability and safety in dynamic unstructured environments. This paper discusses the design, model, control, and performance of the ACEA.
Decoupling Structures for Millimeter Wave Integrated Circuits in Digital CMOS Processes

This brief studies the effect of nonideal decoupling structures on the performance of single-ended circuits operating at the millimeter wave frequency range. Based on a first-order approximation, an upper limit on the impedance of decoupling structures is derived, given a prespecified accepted degradation in insertion loss. To verify the analysis, a 110-GHz single-ended amplifier with a compact decoupling structure based on distributed interdigitized metal-oxide-metal capacitor is implemented. The full-wave electromagnetic simulations of the decoupling structure show an input impedance of (0.47 – j0.12) <inline-formula> <tex-math notation="LaTeX">$\Omega $ </tex-math></inline-formula> at 110 GHz, and the magnitude is less than <inline-formula> <tex-math notation="LaTeX">$1~\Omega $ </tex-math></inline-formula> from 82 to 144 GHz. The degradation in the insertion loss of the matching network is simulated to be less than 0.5-dB compared with the use of ideal decoupling capacitors at 110 GHz. The area of the decoupling structure is <inline-formula> <tex-math notation="LaTeX">$18\times 100 ~\mu \text{m}^{2}$ </tex-math></inline-formula> when implemented in 65-nm digital CMOS process.
Neurokinin B levels in maternal circulation during early pregnancy

Abstract Neurokinin B levels were measured between the 10th–20th weeks of pregnancy, i.e., prior to the development of clinical symptoms, in women who developed preeclampsia or delivered a growth-restricted baby. No difference was found in plasma neurokinin B levels, although neurokinin B levels increased slightly towards term.
Conditional discrimination learning in Aplysia californica

Two experiments examined whether the relation between a conditioned stimulus (CS) and an unconditioned stimulus (US) might be brought under the control of contextual stimuli in the invertebrate Aplysia californica. Subjects received exposure to 2 different contexts. In both experiments, a tactile CS was paired with a shock US in one of those contexts. In the other context, that tactile CS was either nonreinforced (Experiment 1) or explicitly unpaired with the shock US (Experiment 2). Responding to the CS during a subsequent test was greater in the context in which that CS had been paired with the US compared with the context in which it had been nonreinforced or unpaired. These findings are discussed in terms of theories of conditional discrimination learning.
Finite element analysis of the effect of medullary contact on fracture healing and remodeling in the intramedullary interlocking nail‐fixed tibia fracture

Intramedullary interlocking nail is an effective treatment for tibial diaphyseal fracture. The contact between medullary rod and diaphyseal cortex is able to enhance fracture stability. However, how and to what degree the contact affects fracture healing and subsequent bone remodeling is still unclear. To investigate this, fracture healing and remodeling algorithms were combined, improved, and used to simulate the healing and remodeling processes in a transverse tibial diaphyseal fracture fixed with an intramedullary interlocking nail device. Two different diaphyseal fracture statuses, three different initial loading levels, and two nail materials were considered. The results showed that the medullary contact could significantly enhance the fixation stability; the strain reduction was up to 80% in the initial granulation callus. However, low initial loading level was found to be a more potential risk factor for the insufficient loading‐induced nonunion other than medullary contact and stiffer nail material. Furthermore, the stabilizing effect of medullary contact diminished when stiff bone tissue formed in the callus; thus, the remodeling in the long‐term was not affected by medullary contact. Copyright © 2016 John Wiley & Sons, Ltd.
Temporal dynamics of inducible anti‐herbivory defenses in the brown seaweed Ascophyllum nodosum (Phaeophyceae)1

Anti‐herbivory defenses support persistence of seaweeds. Little is known, however, about temporal dynamics in the induction of grazer‐deterrent seaweed traits. In two induction experiments, consumption rates of the periwinkle Littorina obtusata (L.) on the brown seaweed Ascophyllum nodosum (L.) Le Jolis were measured in 3‐d intervals. Changes in palatability of directly grazed A. nodosum were tested every 3 d with feeding assays using fresh and reconstituted seaweed pieces. Likewise, assays with fresh A. nodosum assessed changes in seaweed palatability in response to water‐borne cues from nearby grazed conspecifics. Consumption rates of L. obtusata varied significantly during the 27‐d induction phase of each experiment. Direct grazing by L. obtusata lowered palatability of fresh and reconstituted A. nodosum pieces to conspecific grazers after 15 d as well as after 6 and 12 d, respectively. After 12, 18, and 24 d, fresh A. nodosum located downstream of L. obtusata‐grazed conspecifics was significantly less palatable than A. nodosum located downstream of ungrazed conspecifics. Changes in L. obtusata consumption rates and A. nodosum palatability during both induction experiments suggest temporal variation of grazer‐deterrent responses, which may complicate experimental detection of inducible anti‐herbivory defenses.