Miracle-dz/UniFAR-FTUs huggingface dataset:
The relationship between isokinetic knee extension and flexion strength with soccer kick kinematics: an electromyographic evaluation.

AIM The purpose of this study was to investigate the relationship between isokinetic strength knee testing and soccer kick kinematics using electromyography (EMG). METHODS Thirteen pubertal soccer players (age: 14.3+/-0.4 years) performed maximum instep soccer kicks, while knee angular position of the swinging leg was recorded using a twin-axis electrogoniometer. Bipolar surface EMG activity of the vastus medialis, vastus lateralis and biceps femoris (BF) muscles was recorded. The subjects also performed maximum knee extension and flexion efforts at concentric angular velocities of 1.04, 3.14 and 5.23 rad x s(-1) and eccentric angular velocities of 1.04 and 3.14 rad x s(-1). RESULTS The correlation coefficients between isokinetic moments and knee angular velocity values during the kick ranged from 0.609 to 0.898 for concentric moments and from 0.431 to 0.612 for eccentric moments. Agonist EMG values during isokinetic tests ranged from 63.17+/-19.9% to 128.7+/-34.9% maximum voluntary contraction (MVC). Antagonist EMG levels ranged from 9.76+/-6.12% to 36.91+/-22.81% MVC. The corresponding EMG values during the soccer kick ranged from 12.78+/-6.8% to 122.34+/-61.5% MVC and increased as the foot approached the ball. CONCLUSION Isokinetic tests at intermediate and fast angular velocities are adequate for monitoring strength training programs in soccer. However, muscle activation patterns differ between the two movements, especially those of the BF muscle.
Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium

ABSTRACT Host cell proteases that cleave the hemagglutinin (HA) of influenza viruses in the human respiratory tract are still not identified. Here we cloned two human type II transmembrane serine proteases with known airway localization, TMPRSS2 and HAT, into mammalian expression vector. Cotransfection of mammalian cells with plasmids encoding HA and either protease resulted in HA cleavage in situ. Transient expression of either protease in MDCK cells enabled multicycle replication of influenza viruses in these cells in the absence of exogenous trypsin. These data suggest that TMPRSS2 and HAT are candidates for proteolytic activation of influenza viruses in vivo.
Calibration of interconnect corners using on-chip ring oscillators

Interconnect corners should accurately reflect actual interconnect in silicon to ensure proper design signoff. On-chip ring oscillator (ROSC) based calibration of interconnect corners is proposed. It comprises extraction of ROSC delay as a function of interconnect resistance and capacitance, projection of measured delay on that function, and identifying how existing corners should be adjusted. Simulation using a new calibrated corner demonstrates an excellent match with measurement in 14-nm test chips.
molecular markers and phylogenetic lationship of rice genotypes resistant to tungro virus

Multivariate analyses were performed using 13 morphological traits and 13 molecular markers (10 SSRs and three ISSRs) to assess the phylogenetic relationship among tungro resistant genotypes. For morphological traits, the genotypes were grouped into six clusters, according to D statistic and Canonical vector analysis. Plant height, days to flowering, days to maturity, panicle length, number of spikelet per panicle, number of unfilled grain per panicle and yield were important contributors to genetic divergence in 14 rice genotypes. Based on Nei’s genetic distance for molecular studies, seven clusters were formed among the tungro resistant and susceptible genotypes. Mantel’s test revealed a significant correlation (r = 0.834*) between the morphological and molecular data. To develop high yielding tungro resistant varieties based on both morphological and molecular analyses, crosses could be made with susceptible (BR10 and BR11) genotypes with low yielding but highly resistant genotypes, Sonahidemota, Kumragoir, Nakuchimota, Khaiyamota, Khairymota and Kachamota. The chi-square analysis for seven alleles (RM11, RM17, RM20, RM23, RM80, RM108 and RM531) of SSR and five loci (RY1, MR1, MR2, MR4 and GF5) of three ISSR markers in F2 population of cross, BR11 Sonahidemota, showed a good fit to the expected segregation ratio (1:2:1) for a single gene model. 2013 Académie des sciences. Published by Elsevier Masson SAS. All rights reserved. Corresponding author. E-mail address: alatif1965@yahoo.com (M.A. Latif).
Berberine therapy of hypertyraminemia in patients with liver cirrhosis.

plasma tyramine concentrations ewre abnormally high in cirrhotic patients with hepatic encephalopathy. Oral administration of berberine hydrochloride corrected hyperyraminemia in cirrhotics and also prevented the elevation of plasma tyramine levels following the oral tyrosine load, probably because of berberine-inhibition of bacterial tyrosine decarboxylase in the intestine. This is a new approach as Anti-amine therapy for cirrhotic patients
Identification of two KH domain proteins in the alpha‐globin mRNP stability complex.

Accumulation of globin mRNAs during erythroid differentiation is dependent on their extraordinary stability. The longevity of human alpha‐globin mRNA is associated with a ribonucleoprotein complex (alpha‐complex) formed on the 3′ untranslated region (3′UTR). One or more of the proteins within this alpha‐complex contain strong polycytosine [poly(C)] binding (alpha PCB) activity. In the present report we purify alpha PCB activity from human erythroid K562 cells. Although not able to bind the alpha‐globin 3′UTR directly, alpha PCB activity is sufficient to complement alpha‐complex formation in a cytosolic extract depleted of poly(C) binding activity. Peptide microsequencing demonstrates that alpha PCB activity contains two structurally related poly(C) binding proteins. These two proteins, alpha‐complex protein (alpha CP)‐1 and −2, have an overall structural identity of 80% and contain three repeats of the K homology (KH) domain which is found in a subset of RNA binding proteins. Epitope‐tagged recombinant alpha CP‐1 and alpha CP‐2 expressed in cells are each incorporated into the alpha‐complex. We conclude that alpha CP‐1 and alpha CP‐2, members of the KH domain RNA binding protein family, are involved in formation of a sequence‐specific alpha‐globin mRNP complex associated with alpha‐globin mRNA stability. As such this represents the first example of a specific function for this class of proteins and suggests potential roles for other members of this protein family.
Clinical course of spontaneous subarachnoid hemorrhage

Over 2 years, we identified 171 patients in King County, Washington, experiencing an incident subarachnoid hemorrhage and characterized their clinical course and outcome. Most (65%) were women and most (68%) were under age sixty-five. Only five died without medical attention. The remaining 166 patients were hospitalized and had CTs of the head. Of these, 103 underwent aneurysm surgery, 40 developed acute hydrocephalus, 32 had symptomatic vasospasm, and 30 re-bled. Sixty-eight percent (68%) survived to 1 month after the bleed and 62% to 1 year. Independent predictors of good recovery by 1 month after the bleed included youth, a high score on the admission Glasgow Coma Scale, and absence of blood on the first CT. In this population-based series, at 1 month after the bleed, approximately one-third of patients were dead, one-third had neurologic deficits, and one-third were doing well.
Online High-Power P-i-N Diode Chip Temperature Extraction and Prediction Method With Maximum Recovery Current di/dt

P-i-N diode chip temperature is a significant indicator when evaluating the reliability of high-power converters. The feasibility of state-of-the-art thermosensitive electrical parameter (TSEP) extraction strategies for a high-power module is investigated and the limitations of using forward voltage drop for high-power P-i-N diode TSEP are explored. In the widely employed half-bridge topology, by detailed analysis of the upper antiparallel diode reverse recovery process due to lower nonideal insulated-gate bipolar transistor switching behavior, the inherent monotonic relationship between the maximum recovery current rate did/dt and chip temperature is disclosed. The maximum did/dt during the recovery period is chosen as the better TSEP, which can accurately reflect P-i-N diode chip temperature variation. Fortunately, by monitoring the negative peak voltage on the parasitic inductor between the Kelvin and power emitters under different temperatures, the maximum recovery rate did/dt can be readily determined. Consequently, additional passive components are not required for P-i-N diode chip temperature extraction, which is practical and cost-effective for high-power applications. Finally, a dynamic switching characteristics test platform based on a half-bridge topology is designed and adopted to experimentally verify the theoretical analysis. The experimental results show that the dependence between P-i-N diode chip temperature and the maximum recovery did/dt is approximately linear. This leads to a 3-D lookup table that can be used to estimate online P-i-N diode chip temperature.
The application of cassette dosing for pharmacokinetic screening in small-molecule cancer drug discovery

Pharmacokinetic evaluation is an essential component of drug discovery and should be conducted early in the process so that those compounds with the best chance of success are prioritized and progressed. However, pharmacokinetic analysis has become a serious bottleneck during the ‘hit-to-lead’ and lead optimization phases due to the availability of new targets and the large numbers of compounds resulting from advances in synthesis and screening technologies. Cassette dosing, which involves the simultaneous administration of several compounds to a single animal followed by rapid sample analysis by liquid chromatography/tandem mass spectrometry, was developed to increase the throughput of in vivo pharmacokinetic screening. Although cassette dosing is advantageous in terms of resources and throughput, there are possible complications associated with this approach, such as the potential for compound interactions. Following an overview of the cassette dosing literature, this article focuses on the application of the technique in anticancer drug discovery. Specific examples are discussed, including the evaluation of cassette dosing to assess pharmacokinetic properties in the development of cyclin-dependent kinase and heat shock protein 90 inhibitors. Subject to critical analysis and validation in each case, the use of cassette dosing is recommended in appropriate chemical series to enhance the efficiency of drug discovery and reduce animal usage. [Mol Cancer Ther 2007;6(2):428–40]
Inhaled mannitol identifies methacholine‐responsive children with active asthma

Inhaled mannitol has been developed for bronchial challenge testing in adults. This study determined if mannitol could identify children with active asthma and responsive to methacholine, and whether mannitol challenge was faster to complete than methacholine challenge. Twenty‐five children (aged 6–13 years) responsive to methacholine and 10 nonasthmatic children unresponsive to methacholine were studied. The methacholine challenge (Cockcroft protocol) was followed by a mannitol challenge on separate days.
Performance Analysis of Singhal-Kshemkalyani ’ s Implementation of Vector Clock

Implementation of vector clock is a fundamental problem in distributed system algorithms. Vector clock is strongly consistent, thus gives a total ordering of processes in terms of causality. But, state forward implementation of vector clock is not scalable. This paper studies Singhal-Kshemkalyani’s implementation of vector clock. Our analysis dictates that Singhal-Kshemkalyani’s implementation reduces the message size significantly over the naïve vector clock implementation.
Electron microscopic identification of three classes of oligodendrocytes and a preliminary study of their proliferative activity in the corpus callosum of young rats

In recent electron microscope studies of the corpus callosum in 60–80 gm male rats, some of the cells were identified as microglia by staining with the weak silver carbonate method of del Rio‐Hortega, and others as astrocytes by staining with the gold chloride sublimate method of Ramón y Cajal. In the present work, the cells which did not belong in one of these two groups were examined in the light microscope using semithin sections stained with toluidine blue and in the electron microscope using thin sections stained with uranyl‐lead.
Electrophysiological source analysis of passive self-motion

The neural processes underlying perception of motion are relatively unknown. In this study Electroencephalography (EEG) is used to investigate the neural responses to passive self-motion. A Stewart platform was employed to translate subjects forwards and backwards while high-density EEG data was recorded. Modern source modeling methods were combined with classical waveform and topographic analyses to determine the electrophysiological correlates of motion processing.
Title Page Molecular Pathways: Current Role and Future Directions of the Retinoic Acid Pathway In Cancer Prevention and Treatment Authors:

Retinoids and their naturally metabolized and synthetic products (e.g. all-trans retinoic acid, 13cis retinoic acid, bexarotene) induce differentiation in various cell types. Retinoids exert their actions mainly through binding to the nuclear retinoic acid receptors (α, β, γ), which are transcriptional and homeostatic regulators whose functions are often compromised early in neoplastic transformation. The retinoids have been investigated extensively for their utility in cancer prevention and treatment. Success has been achieved with their use in the treatment of subtypes of leukemia harboring chromosomal translocations. Promising results have been observed in the breast cancer prevention setting, where fenretinide prevention trials have provided a strong rationale for further investigation in young women at high-risk for breast cancer. Ongoing phase 3 randomized trials investigating retinoids in combination with chemotherapy in non-small cell lung cancer aim to definitively characterize the role of retinoids in this tumor type. The limited treatment success observed to date in the prevention and treatment of solid tumors may relate to the frequent epigenetic silencing of RARβ. Robust evaluation of RARβ and downstream genes may permit optimized use of retinoids in the solid tumor arena. Research. on January 21, 2018. © 2013 American Association for Cancer clincancerres.aacrjournals. org Downloaded from Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on January 15, 2013; DOI: 10.1158/1078-0432.CCR-12-3175
Commentary - Major Cholesky Would Feel Proud

Probably more than any other group, authors Lustig, Marsten, and Shanno have led the way in demonstrating the effectiveness of interior methods for solving large, real-world linear programs. For several years they have written at length about things they have actually done. There are no pies in the sky, no secrets. They have explored a multitude of algorithmic ideas and implementation strategies, and they have done more than could be asked to share their experience with the rest of the world. Here, the authors look back on a decade's events that revived barrier methods for constrained optimization and eventually led to their production LP solver OB1. The results reported are indeed impressive. In this commentary, we focus mostly on the “engine”—the Cholesky factorizer—that has made OB1 such a practical success. INFORMS Journal on Computing, ISSN 1091-9856, was published as ORSA Journal on Computing from 1989 to 1995 under ISSN 0899-1499.
Discharge Analysis of EAST H-Mode for Designing Compressed Plasma

Some electric parameters of Experimental Advanced Superconducting Tokamak shot #41195 are analyzed out for compressed plasma at its flat-top phase—the phase has 32-s stationary H-mode plasma discharge and the pulse is long enough for accommodating the compression process. A good knowledge of the total plasma inductance is benefit to map the discharging evolution of vertical magnetic field judged by Maxwell equations, whose nonlinear component is to analyze the effect of noninductive current drive, including the effect of bootstrap current. Furthermore, the relationship of vertical magnetic field and line-averaged density is derived and validated during flat-top phase for given plasma current. An increase in magnetic strength of vertical field will allow high temperature, high density, high beta, and high bootstrap current fraction to be achieved, offering an attractive regime for compressed plasma to approach the Lawson parameter.
Does mindfulness mediate the association between attachment dimensions and Borderline Personality Disorder features? A study of Italian non-clinical adolescents

The aim of this study was to assess whether mindfulness mediates the association between attachment dimensions and features of Borderline Personality Disorder (BPD) in a sample of 501 Italian high-school students. Low scores on Confidence and high scores on Need for Approval and Preoccupation with Relationships attachment scales was significantly related to the number of BPD features (adjusted R 2 = .21, p < .001). Further, mindfulness scores were negatively associated with Need for Approval and Relationships as Secondary attachment scales (adjusted R 2 = .14, p < .001). Finally, mindfulness scores were negatively associated with the number of BPD features (adjusted R 2 = .15, p < .001). Mediation analyses showed that the relationship between Need for Approval and BPD was completely mediated by the mindfulness effects. Our results in non-clinical adolescents are consistent with Bateman and Fonagy's (2004) hypothesis that the link between attachment disturbances and BPD features may be mediated by deficits in mentalization, at least as these are operationalized by low mindfulness.
IL28B genotype is associated with differential expression of intrahepatic interferon‐stimulated genes in patients with chronic hepatitis C

Genetic variation in the IL28B (interleukin 28B; interferon lambda 3) region has been associated with sustained virological response (SVR) rates in patients with chronic hepatitis C (CHC) who were treated with peginterferon‐α and ribavirin. We hypothesized that IL28B polymorphism is associated with intrahepatic expression of interferon‐stimulated genes (ISGs), known to influence treatment outcome. IL28B genotyping (rs12979860) and whole‐genome RNA expression were performed using liver biopsies from 61 North American patients with CHC. After correction for multiple testing (false discovery rate < 0.10), 164 transcripts were found to be differentially expressed by IL28B‐type. The interferon signaling pathway was the most enriched canonical pathway differentially expressed by IL28B‐type (P < 10−5), with most genes showing higher expression in livers of individuals carrying the poor‐response IL28B‐type. In 25 patients for which treatment response data were available, IL28B‐type was associated with SVR (P = 0.0054). ISG expression was also associated with SVR; however, this was not independent of IL28B‐type. Analysis of miR‐122 expression in liver biopsies showed reduced miR‐122 levels associated with poorer treatment outcome, independently of IL28B‐type. No association was observed between IL28B‐type and levels of liver IL28B or IL28A messenger RNA expression. IL28B protein sequence variants associated with rs12979860 were therefore investigated in vitro: no differences in ISG induction or inhibition of HCV replication were observed in Huh7.5 cells. Conclusion: The good response IL28B variant was strongly associated with lower level ISG expression. The results suggest that IL28B genotype may explain the relationship between hepatic ISG expression and HCV treatment outcome, and this is independent of miR‐122 expression. IL28B‐type was not associated with intrahepatic IL28B messenger RNA expression in vivo. Further investigation of the precise molecular mechanism(s) by which IL28B genetic variation influences HCV outcomes is warranted. (HEPATOLOGY 2010)
Immunomodulation by Bordetella pertussis: antiviral effects.

Treatment of mice by intraperitoneal inoculation of pertussis vaccine or lipopolysaccharide extracted from B. pertussis will effect resistance to rabies virus, encephalomyocarditis virus, Semliki Forest virus, and Herpes simplex virus. Our previous observations indicated that treatment of C3H/HeN (+/nu) and BDF1 mice with pertussis vaccine injected i.p. five days prior to a mouse adenovirus lethal dose i.p. challenge elicited resistance to clinical disease and death. Susceptibility returned to a portion of the test population 35 days after pertussis vaccine treatment. The pertussis vaccine induced resistance developed in athymic (nude) mice also; however, the population succumbed to infection 35 days later. Titration of pertussis vaccine with respect to induction of resistance indicated the median effective dose (ED50) was approximately 25 micrograms dry weight. This report describes the antiviral activity of acellular components extracted from pertussis vaccine. Extraction of B. pertussis cells with 1.0M NaCl and ammonium sulfate fractionation (20-40% saturation) of the extract resulted in an acellular preparation that induced resistance to lethal dose mouse adenovirus infection. The resistance inducing activity was retained after treatment of the extract with detergent (GAF Emulphogene BC 720) to remove lipopolysaccharide and adsorption to alum gel. Comparison of endotoxin content of pertussis vaccine acellular fractions, polysaccharide fraction and purified lipopolysaccharide suggested that endotoxin probably plays a role in the induction of resistance. The endotoxin content of a Emulphogene-treated preparation that protected 80% of a test population was 39 ng. The lipopolysaccharide extracted from Escherichia coli, Vibrio cholerae, Salmonella typhimurium, and Salmonella minnesota did not induce a resistant state seven days after administration; however, lipopolysaccharide extracted from B. pertussis induced a resistant state. (ABSTRACT TRUNCATED AT 250 WORDS)
Longitudinal deformation bench testing using a coronary artery model: a new standard?

Objectives To compare susceptibility of five different stent platforms with longitudinal stent deformation (LSD) using a clinically relevant bench testing model simulating both short and long malapposed lengths. Background Recent data suggest that design modifications to the Promus Element stent which led to the Promus Premier stent has reduced susceptibility to LSD. However, susceptibility to LSD at long malapposed lengths has not been tested. Furthermore, the mechanisms behind susceptibility to LSD are as yet unclear. Methods The Omega, Integrity, Multilink 8, Biomatrixand Promus Premier stent platforms were tested. The Omega, Integrity and Multilink 8 platforms were used in place of their drug-eluting equivalents. 3.5 mm stents were deployed in a stepped tube with the distal portion fixed and the proximal test section exposed. The force required to compress stents by a fixed distance at different exposed lengths was compared. Symmetrical and point loading were used. Results The Promus Premier was longitudinally as strong as Multilink and Integrity at a short exposed length (4 mm) but weaker, in between Omega and the other platforms, at longer exposed lengths (12 mm). As previously noted, the Omega (Promus Element) platform was significantly weaker than the other stents and Biomatrix was the strongest stent. Conclusion Susceptibility to LSD varies depending on length of malapposed segment when tested using a clinically relevant model as in this study. The mechanisms behind the susceptibility are likely multifactorial, including connector number, strut thickness, connector alignment and ring orientation but remain to be elucidated.