Miracle-dz/UniFAR-FTUs huggingface dataset:
Anti-edema and antioxidant combination therapy for ischemic stroke via glyburide-loaded betulinic acid nanoparticles

Stroke is a deadly disease without effective pharmacotherapies, which is due to two major reasons. First, most therapeutics cannot efficiently penetrate the brain. Second, single agent pharmacotherapy may be insufficient and effective treatment of stroke requires targeting multiple complementary targets. Here, we set to develop single component, multifunctional nanoparticles (NPs) for targeted delivery of glyburide to the brain for stroke treatment. Methods: To characterize the brain penetrability, we radiolabeled glyburide, intravenously administered it to stroke- bearing mice, and determined its accumulation in the brain using positron emission tomography-computed tomography (PET/CT). To identify functional nanomaterials to improve drug delivery to the brain, we developed a chemical extraction approach and tested it for isolation of nanomaterials from E. ulmoides, a medicinal herb. To assess the therapeutic benefits, we synthesized glyburide-loaded NPs and evaluated them in stroke- bearing mice. Results: We found that glyburide has a limited ability to penetrate the ischemic brain. We identified betulinic acid (BA) capable of forming NPs, which, after intravenous administration, efficiently penetrate the brain and significantly reduce ischemia-induced infarction as an antioxidant agent. We demonstrated that BA NPs enhance delivery of glyburide, leading to therapeutic benefits significantly greater than those achieved by either glyburide or BA NPs. Conclusion: This study suggests a new direction to identify functional nanomaterials and a simple approach to achieving anti-edema and antioxidant combination therapy. The resulting glyburide- loaded BA NPs may be translated into clinical applications to improve clinical management of stroke.
AN INTRODUCTION TO ASSET ALLOCATION OF PROPERTY IN A MIXED ASSET PORTFOLIO

Although it is widely accepted that property is an important asset class in an investment portfolio, the role and significance of property is still debated (Lekander, 2015; Reddy, 2016b). There is also a gap between empirical evidence and the practices of portfolio managers, with a few studies finding that the asset allocation for property in mixed asset portfolios (comprising a few asset classes) are lower than optimal recommendations (Reddy, 2016a). Real estate is a unique asset, especially when compared to financial investment assets such as stocks or bonds. Hence, the inclusion of property in mixed asset portfolios requires some alteration to the asset allocation framework (Lekander, 2015; Lee and Stevenson, 2006; Reddy, 2016b). The objective of this paper is to further understand the role of property as an asset class in mixed asset portfolios. The first section discusses the strengths and weaknesses of property as an asset class. The following section looks at the framework used to determine optimal property allocation in mixed asset portfolios, i.e. the constrained Markowitz efficient frontier. Finally, empirical evidence regarding the performance of property and relevant asset classes in mixed asset portfolios is summarized. This serves to provide a brief overview of methodology used to investigate the performance of property in mixed asset portfolios as well as general findings and implications. Despite its disadvantages, property is still able to provide attractive returns and diversification benefits to a mixed asset portfolio. Property investments are also found to be more return enhancing than risk reducing (Olaleye, 2011; Oyedele et al., 2013; Oyedele, 2014) as well as resilient in periods of financial crisis due to its lower correlation with other asset classes. (Newell et al., 2013; Oyedele, 2014; Newell et al., 2015).
EPOCH Network of Expertise Centres as a mechanism for bridging the knowledge gap between Cultural Institutions and Information and Communication Technologies professionals

In order to overcome the major challenges and gain from the opportunities phased by the Cultural Heritage (CH) institutions as they enter into the digital world, EPOCH developed the Network of Expertise Centers in CH. This paper presents the main methodological elements, and the roadmap behind the creation of the Network of Expertise in CH. The main objective of this network is to support the understanding of both worlds, provide training and facilitate knowledge acquisition of the CH+ICT domain, improve methodologies and techniques to fit better with the needs of the users and debate new ways to introduce and use technology in the CH institutions. The methodology known as Learning Network integrates action learning techniques with the network approach, producing a very powerful mechanism for sharing knowledge between different organisations. The vision is to create a network of centres, organised in a Europe-wide network, integrating a number of local CH and ICT institutions, policymakers, companies, research institutions and other stakeholders with a regional mission to improve the sector. The paper will further discuss the lessons learned and the successes and challenges encountered during the implementation of the network.
1 Experimental Settings 1 . 1 Weight Initialization

For all models, 300D 840B GloVe pretrained vectors [6] are used as word embedding and not updated during training. Adam optimizer [4] is used for training, and the learning rate is annealed according to cosine schedule [5] with the initial learning rate of 0.001. For all models, we added the L2 norm of the parameters to the classification loss with the factor of 0.002. The dimensions of encoder states and MLP hidden layers are set to 300 and 1024 respectively. Batch normalization [3] and dropout [8] is applied to the input and each layer output of the MLP. Dropout is also applied to
Research-based principles of early intervention explode the myth that nothing works for economically disadvantaged children

decades. On one hand, the neurobiological, behavioral, and social sciences have seen an explosion of research on childrens development (Shonkoff & Phillips, 2000). These scientific advances have dramatically increased our capacity to intervene and support highly vulnerable children. On the other hand, it is astonishing how little this growing body of research has improved the prospects for children growing up most at risk. With social and economic circumstances placing more and more families at high risk (Wertheimer & Croan, 2003), no one would question the urgency of finding new ways to break the cycle of disadvantage. Yet despite nearly half a century of considerable research, we have rarely used the findings of these studies constructively to improve policy and practice for disadvantaged children and their families.
Title Use of a promiscuous , constitutively-active bacterial enhancer-binding protein to define the Ï� 54 ( RpoN ) regulon of Salmonella Typhimurium LT 2 Permalink

Background: Sigma54, or RpoN, is an alternative σ factor found widely in eubacteria. A significant complication in analysis of the global σ regulon in a bacterium is that the σ RNA polymerase holoenzyme requires interaction with an active bacterial enhancer-binding protein (bEBP) to initiate transcription at a σ-dependent promoter. Many bacteria possess multiple bEBPs, which are activated by diverse environmental stimuli. In this work, we assess the ability of a promiscuous, constitutively-active bEBP—the AAA+ ATPase domain of DctD from Sinorhizobium meliloti—to activate transcription from all σ-dependent promoters for the characterization of the σ regulon of Salmonella Typhimurium LT2. Results: The AAA+ ATPase domain of DctD was able to drive transcription from nearly all previously characterized or predicted σ-dependent promoters in Salmonella under a single condition. These promoters are controlled by a variety of native activators and, under the condition tested, are not transcribed in the absence of the DctD AAA+ ATPase domain. We also identified a novel σ-dependent promoter upstream of STM2939, a homolog of the cas1 component of a CRISPR system. ChIP-chip analysis revealed at least 70 σ binding sites in the chromosome, of which 58% are located within coding sequences. Promoter-lacZ fusions with selected intragenic σ binding sites suggest that many of these sites are capable of functioning as σ-dependent promoters. Conclusion: Since the DctD AAA+ ATPase domain proved effective in activating transcription from the diverse σdependent promoters of the S. Typhimurium LT2 σ regulon under a single growth condition, this approach is likely to be valuable for examining σ regulons in other bacterial species. The S. Typhimurium σ regulon included a high number of intragenic σ binding sites/promoters, suggesting that σ may have multiple regulatory roles beyond the initiation of transcription at the start of an operon.
THE ROLE OF MEDIATED LEARNING AND METACOGNITION IN THE IMPROVEMENT OF SCHOOL PERFORMANCE ON DISTANCE LEARNING BY MEANS OF IMPLEMENTING INFORMATION AND COMMUNICATION TECHNOLOGIES (ICT) – RESEARCH-ACTION PROJECT –

This paper is an outline of an on-going project we are implementing in Romania. This is the first of its kind nationwide, given the systemic integrative approach of the role played by mediation pedagogy, cooperative learning and metacognition in the betterment of school performance by implementing information and communication technology. These all have so far been treated only separately. This project is based on an interdisciplinary approach, and is motivated by the ever increasing interest manifested, in the last decades, in the development of new learning strategies meant to improve school performance of both pupils and students. These strategies should be based on the paradigm set by cognitive psychology and on the research results obtained in developmental psychology, educational psychology, the psychology of learning, modern didactics, the sociology of education, information technology, educational communications and technology, etc. Below is the synthesis of our research, pointing to the interdisciplinary theoretical support on which our project is based.
pregnant Neanderthal women

Models of Neanderthal energetics and energy requirements suggest they required an average daily caloric intake well above the average for anatomically modern human foragers. The reasons stated for this include higher basic metabolic rates, less efficiency at thermoregulation, less efficiency at hunting, greater degrees of mobility, and reduced sexual division of labor in Neanderthal populations. These models suggest that Neanderthal Daily Energy Expenditure may have reached or exceeded 5500 calories per day. Given that most subsistence and isotope studies also suggest that Neanderthals focused their diet on large, terrestrial herbivores, this paper asks: what would be the nutritional consequences of such a diet on pregnant Neanderthal women? Applying a nutritional ecology perspective to the issue, a modeled diet consisting of 5500 calories per day derived exclusively from large, terrestrial herbivores indicates that such a diet would kill a pregnant Neanderthal woman and her developing fetus. This suggests that much remains to be learned about Neanderthal subsistence, mobility, and social relations, and that there is a long way to go before explaining the causes of Neanderthal extinction and modern human success in Europe and the Mediterranean region between 30,000 and 50,000 years ago. 2011 Elsevier Ltd and INQUA. All rights reserved.
Coordination of Mobile Agents for Wireless Sensor Network Maintenance

In this paper, we study the problem of wireless sensor network (WSN) maintenance using a team of collaborative autonomous mobile agents. The agents are deployed in the area of the WSN in such a way that would minimize the time it takes them to reach a failed sensor and repair it. The team must constantly optimize its collective deployment to account for occupied agents. The objective is to define the optimal deployment and task allocation strategy, that minimize the solution cost. The solution cost is a linear combination of the weighted sensors’ downtime, the agents’ traveling distance and penalties incurred due to unrepaired sensors within a certain time limit. A constrained variation of the problem where agents are subject to capacity constraints is also considered. Our solutions are inspired by research in the field of computational geometry and the design of our algorithms is based on state of the art approximation algorithms for the classical problem of facility location. We empirically compare and analyze the performance of several proposed algorithms. The sensitivity of the algorithms’ performance to the following parameters is analyzed: agents to sensors ratio, sensors’ sparsity, frequency of failures and repair duration.
IMPACT OF INSAT-OBSERVED KELVIN WAVE-TYPE DISTRUBAN CES DURING SUMMER MONSOON

In this study, role of equatorial wave disturbances over the tropical Indian Ocean and their linkage in the genesis and intensification of monsoon systems over north Indian Ocean have been investigated. For this purpose, unique features of major cloud clusters of the size extending around 1000-2000 km longitudinally and about 500-700 km latitudinally were examined from satellite observed cloud imagery and CMVs obtained from INSAT satellites during different monsoon seasons for the period 1988 to 2007. NCMRWF, ECMWF and NOAA data have been utilized for monitoring the dynamical changes during the eastward propagation of super cloud clusters over the equatorial Indian Ocean. Influence of these wave disturbances in the form of rhythmic eastward propagation of cloud clusters without loosing their identity have been further investigated for the genesis/intensification of monsoon systems over the north Indian Ocean, particularly over the Bay of Bengal. It is inferred from the results of our study that in rare cases super cloud clusters are formed over the equatorial Indian Ocean and propagate eastward. They look like Kelvin wave-type disturbances and in INSAT imagery they resemble fairly well with those imageries for super cloud clusters observed by GMS and GOES satellites over the equatorial Pacific Ocean. But over the Indian Ocean they are little bit less in convection and confined to 10° N and 10° S with less pr opagation speed of the order of 5°~7°/ day. It is further revealed that super cloud cluster developed off Somali coast propagates along the equator and when it passes below Indian peninsula on third and fourth day then there is sudden excitation of strong southwesterly winds at 850 hPa in the domain equator to 10° N and 80° E 90° E. This 850 hPa wind analysis of ECMWF is modified with inputs of INSAT CMVs resulting in better vorticity and moisture advection over the Bay of Bengal thus supporting for the genesis/ intensification of monsoon systems over the north Indian Ocean.
Nudging healthcare professionals towards evidence-based medicine: A systematic scoping review

Translating medical evidence into practice is difficult. Key challenges in applying evidence-based medicine are information overload and that evidence needs to be used in context by healthcare professionals. Nudging (i.e. softly steering) healthcare professionals towards utilizing evidence-based medicine may be a feasible possibility. This systematic scoping review is the first overview of nudging healthcare professionals in relation to evidence-based medicine. We have investigated a) the distribution of studies on nudging healthcare professionals, b) the nudges tested and behaviors targeted, c) the methodological quality of studies and d) whether the success of nudges is related to context. In terms of distribution, we found a large but scattered field: 100 articles in over 60 different journals, including various types of nudges targeting different behaviors such as hand hygiene or prescribing drugs. Some nudges – especially reminders to deal with information overload – are often applied, while others - such as providing social reference points – are seldom used. The methodological quality is moderate. Success appears to vary in terms of three contextual characteristics: the task, organizational, and occupational contexts. Based on this review, we propose future research directions, particularly related to methods (preregistered research designs to reduce publication bias), nudges (using less-often applied nudges on less studied outcomes), and context (moving beyond one-size-fits-all approaches).
ANALYSING SECONDARY VORTEX STRUCTURES IN AN HP TURBINE STAGE USING THE REALISABLE K-Ω SST MODEL

The article analyses the effect of turbulence model selection on the pattern of development and interaction of secondary vortex structures in an HP turbine stage. The basic tool used in the analysis is FlowER, a specialised code developed for studying flow through fluid-flow machine stages and stage sections. The flow calculations performed using a standard k-ω SST turbulence model presented highly unstable behaviour of the rotor passage vortex, which periodically built up, moved up along rotor blade suction side and broke down. On the other hand, the use of the modified version, taking into account realisability constraints, has made it possible to stabilise the rotor passage vortex behaviour.
1 6 RULE BASED EXPERT SYSTEM APPROACH TOWARDS THE RESOLUTION OF THE TOWER OF HANOI

DR KINGSLEY OBAHIAGBON Benson Idahosa University, Benin City. Abstract The tower of Hanoi has been a topic every computer scientist has had to grapple with. Its implementation cuts across a fair range of options. One of the most popular is the use of an effective but non-intuitive method: The Recursion. Although the Recursive method has gained popularity, this paper presents an intuitive approach. By keeping the towers constant and maintaining focus on the disks, a ‘Rule Based Expert System’ poses as an excellent alternative for the resolution of the tower of Hanoi. A usability test on novice users shows significant advantage of the expert system approach over the traditional recursive approach.
RDFe – expression-based mapping of XML documents to RDF triples

RDFe is an XML language for mapping XML documents to RDF triples. The name suffix “e” stands for expression and hints at the key concept, which is the use of XPath expressions mapping semantic relationships between RDF subjects and objects to structural relationships between XML nodes. More precisely, RDF properties are represented by XPath expressions evaluated in the context of an XML node which represents the triple subject and yielding XDM value items which represent the triple object. The expressiveness of XPath version 3.1 enables the semantic interpretation of XML resources of any structure and content. Required XPath expressions can be simplified by the definition of a dynamic context whose variables and functions are referenced by the expressions. Semantic relationships can be across document boundaries, and new XML document URIs can be discovered in the content of input documents, so that RDFe is capable of gleaning linked data. As XPath extension functions may support the parsing of non-XML resources (JSON, CSV, HTML), RDFe can also be used for mapping mixtures of XML and non-XML resources to RDF graphs. Table of
Interaction between Muscle and Bone

Bone densitometric data are often difficult to interpret in children and adolescents because of large inter- and intraindividual variations in bone size. Here, we propose a functional approach to bone densitometry that addresses two questions. Is bone strength normally adapted to the largest physiological loads, that is muscle force? Is muscle force adequate for body size? The theoretical background for this approach is provided by the mechanostat theory, which proposes that bones adapt their strength to keep the strain caused by physiological loads close to a set point. Because the largest physiological loads are caused by muscle contractions, there should be a close relationship between bone strength and muscle force or size. The proposed two-step diagnostic algorithm requires a measure of muscle force or size and a measure of bone mineral content at a corresponding location. The results can be combined into four diagnostic groups. In the first situation, muscle force or size is adequate for height. If the skeleton is adapted normally to the muscle system, the result is interpreted as ‘normal’. If it is lower than expected for muscle force or size, a ‘primary bone defect’ is diagnosed. In the second situation, muscle force or size is too low for height. Even if the skeleton is adapted adequately to the decreased mechanical challenge, this means that bone mass, and presumably strength, are still too low for body height. Therefore, a ‘secondary bone defect’ is diagnosed. Finally, if both muscle force or size and the skeleton are inadequately adapted, a ‘mixed bone defect’ is diagnosed. It is hoped that the more detailed insights thus gained could help to devise targeted strategies for the prevention and treatment of paediatric bone diseases.
Tanzania – Why a Potential Food Exporter is Still Importing Food

Agribusiness is still in its infancy in Tanzania and commercial ventures are found mostly in traditional export crops such as coffee, tea, cotton, cashews, tobacco and, on a much smaller scale, cloves and sisal. Due to declining world market prices for agricultural commodities and rising mineral exports, traditional agricultural exports accounted for only 20 per cent of total merchandise exports in 2006, down from over 55 per cent in 1995/96. Tanzania’s horticultural sector (vegetables, fruits and cut flowers) is still very small and contributes little more than 1 per cent to total merchandise exports. Recently Tanzania’s most important non-traditional agricultural export has become fish and fish products which earned half as much as all traditional agricultural exports in 2006 (USD 138.6 million).
Lethal and Sublethal Effects of Clothianidin on the Development and Reproduction of Bemisia tabaci ( Hemiptera : Aleyrodidae ) MED and MEAM 1

The Bemisia tabaci (Gennadius) cryptic species complex includes important crop pests, and among them, the cryptic species Mediterranean (MED) and Middle East-Asia Minor 1 (MEAM1) cause substantial crop losses in China. The second-generation neonicotinoid clothianidin acts as an agonist of the nicotinic acetylcholine receptor in the insect nervous system and has both stomach and contact activity. In this study, the toxicity of clothianidin and five other insecticides to MED and MEAM1 was examined. The sublethal effects of clothianidin on the development and reproduction of MED and MEAM1 were also investigated. Among the six insecticides tested, clothianidin showed toxicities to both MED and MEAM1 adults with LC50 values of 5.23 and 5.18 mg/liter, respectively. The sublethal effects of clothianidin were assessed by treating MED and MEAM1 adults with the LC25 of 1.58 and 1.13 mg/liter, respectively. The LC25 treatments accelerated the development of the F1 generation but reduced survival and fecundity of both species. Our results indicate that clothianidin could be useful for the management of B. tabaci MED and MEAM1.