Miracle-dz/UniFAR-FTUs huggingface dataset:
Atypical presentation of bronchogenic carcinoma with humeral metastasis

Bronchogenic carcinoma often manifests with some atypical symptoms which delay the diagnosis of malignancy. The primary manifestation of lung cancer with pathological fracture of humerus due to skeletal metastasis is very rare. We hereby report such a case in an elderly nonsmoker male who initially presented with nontraumatic painful swelling of right arm which was found to be due to humeral fracture. However, initial management by the orthopedic surgeon over 3 months did not provide adequate relief. On subsequent evaluation, chest X-ray showed a right hilar mass. Further radiologic imaging and a guided biopsy from lung mass confirmed an adenocarcinoma. Fine needle aspiration from humeral osteolytic lesion also confirmed metastatic deposit. This case highlights the importance of suspecting pathological fracture while dealing with nontraumatic fracture, especially in elderly patients, which avoids the diagnostic delay.
Stark broadening of spectral lines of multicharged ions of astrophysical interest. I - C IV lines. II - SI IV lines

Results are presented on calculations of the electron-, proton-, and ionized helium-impact line widths and shifts for 31 C IV multiplets and 40 Si IV multiplets. These data are compared with observations and are used to investigate the Stark broadening parameter regularities within the spectral series. For both the C IV and Si IV multiplets, a gradual change of the Stark widths was obtained. The reason for this is discussed.
Anti-parasitic and anti-bacterial agents: Studies on 1,4-dihydropyridines and 2,4-diaminoquinazolines

xix Chapter 1: Introduction to Anti-microbials.1 1.1 Overview . 1 1.2 Protozoa . 2 1.2.1 Genus Plasmodium . 2 1.2.1.1 Anti-Malarials . 5 1.2.2 Genus Leishmania . 8 1.2.2.1 Anti-leishmanials . 11 1.3 ESKAPE Pathogens . 12 1.3. 1 Staphylococcus aureus . 14 1.3. 1.1 Staphylococcal Toxins . 15 1.3. 1.2 Antibiotics for Staphylococcus aureus . 17 1.3. 2 Acinetobacter baumannii . 25 1.3. 2.1 Antibiotics for Acinetobacter baumannii.26 Chapter 2: 1,4-Dihydropyridines as Anti-Malarials . 29 2.1 Hantzsch Pyridine Synthesis . 29 2.1.1 Enantioselective Syntheses of 1,4-Dihydropyridines . 30 2.1.2 Biological Activity of 1,4-Dihydropyridine Derivatives . 36 2.2 1,4-Dihydropyridine Syntheses.38 2.2.1 Synthetic Plan . 39 2.2.1.1 Comparison of Methylene and Oxygen Derivatives . 40
The analysis of L-selectin expression intensity (CD62L) on B-lymphocytes in B-cell chronic lymphocytic leukemia cells (B-CLL)

Decreased percentage of B cells expressing L-selectin in B-cell chronic lymphocytic leukemia (B-CLL) is known from literature. The purpose of our studies was to compare the intensity of L-selectin expression on subpopulation of L-selectin positive B-lymphocytes in untreated and treated patients with B-CLL. The lymphocytes were obtained from peripheral blood of 70 patients suffering from B-CLL (40 untreated and 30 after the treatment) and 20 healthy blood donors. The percentage of positive cells and intensity of CD62 L-selectin expression (RFI) were measured on CD19+ B lymphocytes using tri-color fluorochrom labeled monoclonal antibodies and flow cytometric analysis. The lower percentage of L-selectin positive B-cells paralleled with considerable decrease of this selectin intensity was observed in patients with B-CLL in comparison to healthy subjects. Both these changes may contribute to the impaired adhesion and migration of B-cells in B-CLL resulting in the accumulation of these cells in the peripheral blood. In a group of patients entirely responding to the treatment the tendency toward normalization of both measured parameters has been observed.
Progesterone regulation of endometrial factors supporting conceptus growth and development in the ovine uterus

Progesterone Regulation of Endometrial Factors Supporting Conceptus Growth and Development in the Ovine Uterus. (May 2008) Michael Carey Satterfield, B.S., Texas A&M University; M.S., Texas A&M University Co-Chairs of Advisory Committee: Dr. Thomas E. Spencer Dr. Fuller W. Bazer Progesterone is unequivocally required for the establishment and maintenance of pregnancy in all mammals studied. Its known functions are complex and encompass global changes in gene expression. Therefore, studies were conducted to characterize the effects of progesterone on expression of genes for endometrial factors having roles in conceptus growth, implantation and establishment of pregnancy. The first study characterized the effect of an artificially induced early increase in circulating progesterone on conceptus growth and development and regulation of expression of galectin-15 (LGALS15), a recently identified protein secreted by the ovine uterine luminal epithelium (LE). Exogenous progesterone beginning on Day 1.5 postmating accelerated conceptus development on Days 9 and 12. On Day 12 the conceptus was functionally and morphologically advanced to produce greater quantities of interferon tau (IFNT) than blastocysts from control ewes. Further, the endometrium responded to early progesterone and IFNT with early expression of cathepsin L (CTSL), radical S-adenosyl methionine domain containing 2 (RSAD2), and LGALS15 within the endometrium. The second study identifed structural changes within the luminal epithelium which could alter the flux of factors into and out of the uterine lumen to maintain
RESPIRATORY EXERCISES AND THE QUALITY OF LIVES OF ASTHMATIC PATIENTS

Asthma is the most common type of chronic pulmonary diseases, with a high prevalence and incidence. But, despite availability of new drugs, morbidity and mortality rates of the disease is already high all over the world. Considering that the preventive measures and management of the disease have not been enough so far, devising other ways and procedures seems to be of great necessity. To do so, planning self-care practices and pulmonary rehabilitations consequently, will improve quality of lives of those suffering Asthma. Determining the effects of respiratory exercises on the quality of lives of these patients, a trial study was conducted with 92 patients, selected consecutively, and in order to gather the data Asthma Quality of Life Questionnaires (AQLQ) were used. In this research, patients were assigned to contribute in a 3 divided stages of exercise (warm up-exercise-cool down) and then complete the questionnaires after a four weeks period. Findings revealed that self-care programs were effective on the quality of lives of patients. Moreover, significant relations were found in improvement of mood (P=0.0001), physical activity (P=0.0001) and social functions (P=0.0001). To conclude, preventing asthmatic symptoms and promoting quality of patient's lives, it is necessary to recommend such patients to do continuous respiratory exercises.
THE CORRECTION OF CONSTRUCTIVE APRAXIA IN PATIENTS WITH SEQUELS OF BRAIN-VASCULAR ILLNESS.

Autores: Lic Maydané Torres Aguilar , Dr. Hansel Oliva Rodríguez , Lic Jenny Nodarse Ravelo , Lic Mercedes Crespo Moinelo , Lic Tania Francia González , Lic Estela Quesada Rodríguez , MSc Elizabeth Fernández Martínez . CENTRO: Centro Internacional de Restauración Neurológica CIREN. 1 Licenciada en Defectología, Especialista en Neurorrehabilitación, Clínica de Lesiones Estáticas Encefálicas. 2 Médico Especialista de 1er. Grado en Fisiología Normal y Patológica, Departamento de Desarrollo Tecnológico, Escuela Latinoamericana de Medicina (ELAM). 3 Licenciada en Defectología, Especialista en Neurorehabilitación, Clínica de Lesiones Estáticas Encefálicas. 4 Licenciada en Defectología, Especialista en Neurorehabilitación, Clínica de Lesiones Estáticas Encefálicas. 5 Licenciada en Defectología, Especialista en Neurorehabilitación, Clínica de Lesiones Estáticas Encefálicas. 6 Licenciada en Defectología, Especialista en Neurorehabilitación, Clínica de Lesiones Estáticas Encefálicas. 7 MSc Psicología de la salud, Clínica de Lesiones Estáticas Encefálicas. Introducción
TOPICAL REVIEW: Jamming of soft particles: geometry, mechanics, scaling and isostaticity

Amorphous materials as diverse as foams, emulsions, colloidal suspensions and granular media can jam into a rigid, disordered state where they withstand finite shear stresses before yielding. Here we review the current understanding of the transition to jamming and the nature of the jammed state for disordered packings of particles that act through repulsive contact interactions and are at zero temperature and zero shear stress. We first discuss the breakdown of affine assumptions that underlies the rich mechanics near jamming. We then extensively discuss jamming of frictionless soft spheres. At the jamming point, these systems are marginally stable (isostatic) in the sense of constraint counting, and many geometric and mechanical properties scale with distance to this jamming point. Finally, we discuss current explorations of jamming of frictional and non-spherical (ellipsoidal) particles. Both friction and asphericity tune the contact number at jamming away from the isostatic limit, but in opposite directions. This allows one to disentangle the distance to jamming and the distance to isostaticity. The picture that emerges is that most quantities are governed by the contact number and scale with the distance to isostaticity, while the contact number itself scales with the distance to jamming.
EVALUATION OF MEDICATION FOR THE PALLIATIVE CARE PATIENTS-ADVERSE DRUG MONITORING - A PHARMACOVIGILANCE AWARENESS FOR THE PALLIATIVE CANCER PATIENTS RESIDING AT HOME CARE IN AND AROUND VELLORE DISTRICT HOSPITAL - VELLORE MEDICAL COLLEGE HOSPITAL AND CMC HOSPITAL PATIENTS

Palliative care research and treatment is one of the most essential program me for the cancer patients our object is to study the different types of cancer patients-palliative care patients and the drugs they are consuming both the pain killers and other poly pharmacy they are consumed. The main aim of the study is to evaluation of medication – benefit v/s risk factor of the individual drug or combination of drug therapy- the management of medication for the safety of individual patients in order to prolong the safety and span of life.
Anxiety Before and after Coronary Artery Bypass Grafting Surgery: Relationship to QOL

This study aimed to examine the presence of anxiety in patients before and after coronary artery bypass grafting surgery (CABG). Additionally, its relationship to patient's quality of life (QOL), because of effects of psychological factors such as anxiety on CABGs outcomes. Comprehensive data on 187 patients who underwent CABGs were prospectively collected in Fatemeh Zahra university hospital in Sari/Iran preoperative and 18 months follow-up anxiety and QOL in functional status were measured using the state portion of the Spielberger State-Trait anxiety inventory (STAI) and Short Form Health Survey (SF-36) questionnaire respectively. State anxiety scores ranged from 23-67 with a mean of 38±-9.95 before and 20-65 with a mean of 32±-9.40 in 18 months after CABGs. This study demonstrated that most patients (N=108, 57.8 and N=115, 61.5) had low levels of anxiety at both time, respectively. The present study showed significant positive association between pre and postoperative state anxiety (P=0.000) and pre and post operative mental health (P=0.000). Results showed negative correlations between preoperative mental health and preoperative state anxiety (p=0.000), postoperative physical functioning and postoperative state anxiety (p=0.000). It was concluded that identifying patients likely to experience anxiety before CABGs and to highlight risk group will enable us to design specific interventions that predominantly focus on reduce patient's anxiety and improving their QOL.
Mathematical Vistas: From a Room with Many Windows

* Paradoxes in Mathematics * Not the Last of Fermat * Fibonacci and Lucas Numbers: Their Connections and Divisibility Properties * Paper-Folding, Polyhedra-Building and Number Theory * Are Four Colors Enough? * From Binomial to Trinomial Coefficients and Beyond * Catalan Numbers * Symmetry * Parties
Fundamental stellar properties : the interaction between observation and theory : proceedings of the 189th Symposium of the International Astronomical Union, held at the Women's College, University of Sydney, Australia, 13-17 January 1997

Preface. 1. Introduction. 2. Stellar Distances. 3. Stellar Angular Diameters and Radii. 4. Stellar Flux Distributions. 5. Stellar Masses and Surface Gravities. 6. The Stellar Effective Temperature Scale. 7. Stellar Abundances. 8. Stellar Atmospheres. 9. Stellar Oscillations and Pulsations. 10. Stellar Models Versus Observations. 11. Stellar Interiors. 12. Evolved Stars. 13. Stellar Chemical Evolution. 14. Stellar Ages. 15. Conclusion. Discussion. Indexes: Author Index. Subject Index. Object Index.
Characteristic Classes and Integrable Systems. General Construction

We consider topologically non-trivial Higgs bundles over elliptic curves with marked points and construct corresponding integrable systems. In the case of one marked point we call them the modified Calogero-Moser systems (MCM systems). Their phase space has the same dimension as the phase space of the standard CM systems with spin, but less number of particles and greater number of spin variables. Topology of the holomorphic bundles are defined by their characteristic classes. Such bundles occur if G has a non-trivial center, i.e. classical simply-connected groups, $E_6$ and $E_7$. We define the conformal version CG of G - an analog of GL(N) for SL(N), and relate the characteristic classes with degrees of CG-bundles. Starting with these bundles we construct Lax operators, quadratic Hamiltonians, define the phase spaces and the Poisson structure using dynamical r-matrices. To describe the systems we use a special basis in the Lie algebras that generalizes the basis of t'Hooft matrices for sl(N). We find that the MCM systems contain the standard CM systems related to some (unbroken) subalgebras. The configuration space of the CM particles is the moduli space of the holomorphic bundles with non-trivial characteristic classes.
Mechanisms of angiogenesis and lymphangiogenesis in calcific aortic valve stenosis

Aortic valve stenosis (AVS) is the most common valvular disease in Western countries. Pharmacological prevention of AVS having proved unsuccessful, its current treatment is still valve replacement. The etiology of AVS is multifactorial, both genetic and external risk factors predisposing to the active pathological process eventually leading to clinically manifest stenosis. Histological features of the disease resemble those of atherosclerosis, including the accumulation and modification of lipoproteins, inflammation, extracellular matrix remodeling, and calcification. Furthermore, valvular interstitial cells undergo phenotypic differentiation into actively proliferating myofibroblasts, which contribute to the local inflammatory response as well as extracellular matrix remodeling in stenotic aortic valves. Blood vessels also grow into the normally avascular valve leaflets already in the early stages of the disease. This thesis aimed at elucidating the mechanisms behind the pathological neovascularization of the stenotic aortic valves. Furthermore, we characterized valvular lymphangiogenesis and investigated potential factors contributing to the balance between valvular angiogenesis and lymphangiogenesis, focusing on the role of valvular myofibroblasts and mast cells. For this purpose, we studied a total of 117 stenotic valves obtained at valve replacement surgery, and 49 control valves obtained at cardiac transplantations, at valve replacement surgery due to aortic valve regurgitation, or from deceased organ donors whose hearts were unsuitable for use as grafts. The valve leaflets were either used freshly for myofibroblast cell culture or frozen for e.g. PCR and immunohistochemical analyses. First, we assessed the adverse extracellular matrix remodeling of stenotic aortic valves, a process necessary for angiogenic sprouting to occur. We found that the mRNA expression levels of cathepsins S, K, and V, and their inhibitor cystatin C were higher in stenotic aortic valves than in control valves. Furthermore, the total activity of such cathepsins was increased in AVS. In immunohistochemical stainings, the expressions of cathepsin S, cathepsin V, and cystatin C localized to valvular macrophages, chondroblast-like cells, and endothelial cells lining both the valvular surface and the neovessels in the stenotic valves. Next, we characterized the neovessels and lymphatic vessels in stenotic aortic valves and control valves using immunohistochemistry. We found that in addition to immature microvessels, the stenotic aortic valves contained organized arterioles, indicating an advanced stage of angiogenesis. Lymphatic vessels correlated with valvular blood vessels, but were present in much fewer numbers. Valvular mast cells resided close to neovessels and secreted the angiogenic Vascular endothelial growth factor A (VEGF-A). Furthermore, we showed that the lymphangiogenic growth factors VEGF-C and VEGF-D are locally produced in the aortic valves, and that the receptors
Complications of thyroid surgery

This article discusses complications of thyroid surgery which cause persistent morbidity pre- and postoperatively. The factors that promote these complications depend on the experience of the practitioner the type of procedure the lesional character of the pathology being aware that for thyroid cancers the tumor volume the invasive nature and the existence of adenopathy have a very high influence on the occurrence of complications. Risks of preoperative morbidity are determined by factors related to hemorrhages and to tracheo-esophageal fistulas; pleural breaches with penumothorax are observed very rarely. Postoperative complications are dependent on the causal condition the extent of surgical exeresis and the performance of or refrain from lumpectomy. This type of risk includes complications jeopardizing the vital prognosis notably recurring paralyses from those of the superior laryngeal nerve and hypoparathyroidism. Other complications have been reported but are rare and exceptional these are postoperative infection and quadriplegia. The authors mention actions to take in order to reduce these complications to a minimum and state that any subject operated on for the thyroid should be rigorous monitored for immediate complications to set forth a vital prognosis.
Estudio clínico para evaluar el efecto de dos cremas humectantes con protector solar en la piel de pacientes que utilizan tretinoína 0,025% para el tratamiento del fotodaño

Introduccion: La exposicion a la radiacion ultravioleta (RUV) produce un deterioro en la piel denominado fotodano, que puede mejorarse con la aplicacion de tretinoina. Este tratamiento, sin embargo, puede causar efectos colaterales. El objetivo es comparar las diferencias en la eficacia, tolerancia y preferencias al utilizar tretinoina al 0,025%, junto con dos productos hidratantes diferentes. Materiales y metodos: Estudio abierto, prospectivo, doble ciego, randomizado. Cincuenta y siete mujeres de 35 a 55 anos, con dano solar, se aplicaron en el periodo de pre-condicionamiento, una crema humectante en cada hemicara: una con niacinamida y otra solo con componentes hidratantes. Luego, se agrego tretinoina topica al 0,025%. Se evaluo fotodano, tolerancia y preferencias. Resultados: En el periodo de precondicionamiento no se hallaron diferencias significativas en la tolerancia. La perdida trans epidermica de agua (PTEA) fue significativamente peor para el humectante B. La textura de la piel mejoro significativamente para ambos humectantes. En el periodo de tratamiento la tolerancia disminuyo mas para el humectante B en las semanas 2 y 4, mejorando al final del estudio. Los parametros relacionados con foto dano mejoraron, mas para el humectante A. La PTEA aumento en las semanas 2 y 4, mas para el humectante B; para luego disminuir. Comentario: La tretinoina topica es bien tolerada, cuando se la utiliza en combinacion con cremas humectantes. La niacinamida agrega beneficios a la accion hidratante de un producto, ya que cumple un rol en la prevencion de efectos adversos y en la potenciacion de los efectos beneficiosos del retinoide.
Evaluation of CD4+ and CD8+ T Cell Count in Colonic Mucosa of Patients with IBD and IBS

Background: Ulcerative colitis (UC) and Crohn’s disease (CD) are of bowel immune-mediated disorders. Irritable bowel syndrome (IBS) is a multi-factorial functional disease. The aim of study was evaluating of T cells infiltration and counting of two important phenotypes (CD4+,CD8+) between IBS and IBD (Inflammatory Bowel Disease)subtype of Ulcerative colitis patients. Methods: In this analytical-descriptive study, 83 patients including 35 patients with ulcerative colitis and 48 patients with IBS were compared with 37 healthy volunteers. Tissue samples were obtained by colonic biopsy during colonoscopy and evaluated by histological and Immunohistochemistry (IHC) techniques. Results: The study compared 37 healthy volunteers, 35 patients with ulcerative colitis, and 48 patients with IBS. Statistically, there was not any significant difference between these groups and they were matched considering age and gender. There was similarity between IBS patients and healthy volunteers considering CD4 and CD8 T cells count and their ratio. However, CD4 T cells count and CD4/CD8 ratio were significantly higher in ulcerative colitis than healthy volunteers (p<0.001) while CD8 count was lower in comparison with IBS patients and healthy volunteers (p<0.001). Conclusion: CD4 and CD8 T cells infiltrations do not play an important role in mucosal immunity disorder of IBS patients. Further studies are required to evaluate others T cells phenotypes or immune mediators in future. [Ghavidel A, Somi MH, Ebrahimzadeh Z, Halimi M, Tabrizi A. CD4+ and CD8+ T Cell Count in Colonic mucosa of patients with IBD and IBS. J Am Sci 2013;9(9s):79-83]. (ISSN: 1545-1003). http://www.jofamericanscience. org. 11
Drowning and Near-Drowning in Children in the Southeast of Turkey

Aim: This study aimed to analyze and describe the epidemiology, risk factors, and prognosis of pediatric drowning and near-drowning incidents. Materials and Methods: Forty-four children were included in to the study. Data on social demographics, the location of drowning, clinical and laboratory results, and progress as well as outcome of patients were retrospectively investigated. Results: The median age of patients was 4.2±2.9 years. Most of drownings (65.9%) occurred during the summer, in swimming pools (47.7%), and mostly on weekends (70.4%). Sixteen patients (47%) were not supervised by their caregivers. None of the children had received resuscitation before arriving at the emergency department. Clinical outcomes included 10 (22.7%) deaths, 7 (15.9%) discharges with neurologic sequelae, and 27 (61.3%) successful discharges. Conclusion: Public education, safety regulations, lifeguards at swimming pools, restrictions on access to swimming in ponds, canals, and rivers, supervision of children, and increased awareness of this problem are necessary to reduce the rate of pediatric drowning. (JAEM 2015; 14: 16-8)
COMPARISON BETWEEN PLYOMETRIC AND ISOKINETIC TRAINING DURING THREE WEEKS ON ISOKINETIC STRENGTH IN SPORT SCIENCES STUDENTS

The purpose of the present study was to compare the effects of 3 weeks of isokinetic training vs plyometric training of the knee flexors and extensors on isokinetic strength. Twenty four students volunteered to participate, divided into 3 groups: one group performed the isokinetic exercises; a second group performed consecutive jumps, and a third was a control group. The knee extensor and flexor muscle peak torque, total work and average power of each leg were concentrically measured at 300o·s-1 using a Biodex System 3 isokinetic dynamometer. The results indicated that the concentric isokinetic training resulted in increase peak torque. ANOVA analysis between the three groups revealed statistical differences for peak torque (p<0.05) and average power (p<0.05) knee extension right leg and peak torque knee extension left leg (p<0.05).