Miracle-dz/UniFAR-FTUs huggingface dataset:
Spray-Drying Formulation + Process Development Advances Expand Opportunities for Formulations Via Intranasal and Pulmonary Delivery

INTRODUCTION Dry powder inhalers (DPIs) are a leading drug-delivery platform for the treatment of respiratory diseases and have been used successfully to deliver intranasal and pulmonary formulations for a wide range of active pharmaceutical ingredients (APIs) and medical conditions. Increasingly, DPIs are also being considered for systemic drug delivery due to the rapid onset of action of inhaled drug products and exposure to the pulmonary vasculature.
The Role of Hypoxia in the Limbal Vascular Response to Soft Contact Lens Wear

Purpose. Increases in limbal vascular blood flow frequently occur as an accompaniment to conventional soft contact lens wear. This study attempted to discover whether these changes can be induced by the direct influence of oxygen alone in the absence of contact lenses. Methods. Nine people were subjected to monocular anoxia by bathing one randomly chosen eye with 100% nitrogen using gas-tight goggles. Their other eyes served as controls and were exposed to normal air throughout the study. Vascular changes were quantified by image capture and subsequent analysis, with the change in the proportion of the image corresponding to blood vessels (per area) being used as the measure of hyperemia. Results. Nitrogen-exposed eyes showed significantly greater hyperemia (mean perarea change ± 95% confidence interval, 0.023 ± 0.016 compared with control eyes, −0.013 ± 0.013;P =0.004, paired t test). Conclusion. Reduced oxygen concentration at the ocular surface induces more blood flow in limbal vessels. This result provides further evidence that similar changes occurring during soft contact lens wear are caused by lens-induced hypoxia.
Herpes simplex virus VP22–human papillomavirus E2 fusion proteins produced in mammalian or bacterial cells enter mammalian cells and induce apoptotic cell death

Infection by high‐risk HPV (human papillomavirus) is supposed to be the primary cause of cervical cancer. The HPV E2 protein (E2) is a DNA‐binding protein that regulates viral gene expression and is required for efficient viral replication. Overexpression of the E2 protein in cervical cancer cells can induce growth arrest and/or apoptotic cell death, suggesting that E2 might be useful in the treatment of this disease. In the present study, we show that VP22 (herpes simplex virus VP22 protein) can be used to deliver E2 to target cells. VP22–E2 fusion proteins induce apoptosis in transiently transfected HPV‐transformed cervical carcinoma cell lines. However, VP22–E2 fusion proteins do not kill COS‐7 cells, probably because these cells constitutively express the simian‐virus‐40 T antigen and this protein sequesters the tumour suppressor protein p53. When COS‐7 cells producing VP22–E2 are seeded into cultures of HPV‐transformed cells, VP22–E2 enters the non‐producing cells and induces apoptosis. VP22–E2 proteins produced in bacterial cells can also enter cervical cancer cells and induce apoptosis in a dose‐dependent manner. Our results suggest that local delivery of VP22–E2 fusion proteins could be used to treat cervical cancer and other HPV‐associated diseases.
Consumer experience with and attitudes toward health information technology: a nationwide survey

Electronic health records (EHR) are becoming more common because of the federal EHR incentive programme, which is also promoting electronic health information exchange (HIE). To determine whether consumers' attitudes toward EHR and HIE are associated with experience with doctors using EHR, a nationwide random-digit-dial survey was conducted in December 2011. Of 1603 eligible people contacted, 1000 (63%) participated. Most believed EHR and HIE would improve healthcare quality (66% and 79%, respectively). Respondents whose doctor had an EHR were more likely to believe that these technologies would improve quality (for EHR, OR 2.3; for HIE, OR 1.7). However, experience with physicians using EHR was not associated with privacy concerns. Consumers whose physicians use EHR were more likely to believe that EHR and HIE will improve healthcare when compared to others. However, experience with a physician using an EHR had no relationship with privacy concerns.
Possible involvement of stress hormones and hyperglycaemia in chronic mild stress-induced impairment of immune functions in diabetic mice

Stress, an important aspect of modern life, has long been associated with an altered homeostatic state. Little is known about the effect of the life stress on the outcome of diabetes mellitus, especially related to the higher risk of infections. Here, we evaluate the effects of chronic mild stress (CMS) exposure on the evolution of type I diabetes induced by streptozotocin administration in BALB/c mice. Exposure of diabetic mice to CMS resulted in a significant reduction of survival and a sustained increase in blood glucose values. Concerning the immune response, chronic stress had a differential effect in mice with diabetes with respect to controls, showing a marked decrease in both T- and B-cell proliferation. No correlation was found between splenic catecholamine or circulating corticosterone levels and the proliferative response. However, a significant negative correlation was found between glucose levels and concanavalin A- and lipopolysaccharide-stimulated proliferative responses of T and B cells. A positive correlation between blood glucose and splenic catecholamine concentrations was found in diabetic mice but not in controls subjected to CMS. Hence, the present report shows that diabetic mice show a worse performance in immune function after stress exposure, pointing to the importance of considering life stress as a risk factor for patients with diabetes.
Constraint-programming Approach for Multiset and Sequence Mining

Constraint-based data mining is a field that recently has started to receive more attention. Describing a problem through a declarative model enables very descriptive and easy to extend implementations. Our work uses a previous itemset mining model in order to extend it with the capabilities to discover different and interesting patterns that have not been explored yet: multisets and sequences. The classic example domain is the retailer organizations, trying to mine the most common combinations of items bought together. Multisets would allow mining not only this itemsets but also the quantities of each item and sequences the order in with the items are retrieved. In this paper, we provide the background of the original work and we describe the modifications done to the model to extend it and support these new patterns. We also test the new models using real world data to prove their feasibility.
Memory-Logic Hybrid Gate With 3-D Stackable Complementary Latches

In this article, a single-layer complementary latch (CL) and one multilayer CL which are fully compatible with standard FinFET CMOS processes are characterized and their applications are extensively discussed. Through the complementary pair with the 3-D stackable twin-bit resistive random-access memory (RRAM) which consists of a TaON-based resistive film, the CLs feature great area efficiency and stable output responses. By measurement, the characteristics of the 3-D stackable twin-bit RRAM are discussed. Besides, the power, output voltage distribution, and data restoration time of the CLs are analyzed and compared.
Estimation à l'échelle du mouvement d'un réseau multi-caméras non synchronisées

Nous proposons une nouvelle methode d'estimation a l'echelle du mouvement d'un vehicule en utilisant un systeme multi-cameras non synchronisees que nous appelons la methode des triangles. L'algorithme propose utilise les informations issues du calibrage hors ligne des cameras. Nous supposons que la trajectoire entre deux poses de la meme camera en deux instants differents est approximee par un segment lineaire. Les poses relatives des cameras sont estimees par l'algorithme des 5-points [5]. Ensuite, les facteurs d'echelle metrique absolus sont calcules par une resolution lineaire d'un systeme d'equations qui tient compte de la connaissance du calibrage extrinseque et de la linearite du deplacement. Nous verifions la validite de notre methode sur des images simulees et des images reelles de la base de donnees KITTI.
Interaction of the Srb10 Kinase with Sip4, a Transcriptional Activator of Gluconeogenic Genes in Saccharomyces cerevisiae

ABSTRACT Sip4 is a Zn2Cys6 transcriptional activator that binds to the carbon source-responsive elements of gluconeogenic genes in Saccharomyces cerevisiae. The Snf1 protein kinase interacts with Sip4 and regulates its phosphorylation and activator function in response to glucose limitation; however, evidence suggested that another kinase also regulates Sip4. Here we examine the role of the Srb10 kinase, a component of the RNA polymerase II holoenzyme that has been primarily implicated in transcriptional repression but also positively regulates Gal4. We show that Srb10 is required for phosphorylation of Sip4 during growth in nonfermentable carbon sources and that the catalytic activity of Srb10 stimulates the ability of LexA-Sip4 to activate transcription of a reporter. Srb10 and Sip4 coimmunoprecipitate from cell extracts and interact in two-hybrid assays, suggesting that Srb10 regulates Sip4 directly. We also present evidence that the Srb10 and Snf1 kinases interact with different regions of Sip4. These findings support the view that the Srb10 kinase not only plays negative roles in transcriptional control but also has broad positive roles during growth in carbon sources other than glucose.
Later emotional and behavioral problems associated with sleep problems in toddlers: a longitudinal study.

IMPORTANCE Childhood sleep problems have been linked to a range of adverse health outcomes, but there is limited knowledge as to the temporal association between sleep problems and subsequent emotional and behavioral problems in young children. OBJECTIVE To examine whether sleep problems in toddlers aged 18 months are related to both concurrent and subsequent emotional and behavioral problems in preschool children aged 5 years. DESIGN, SETTING, AND PARTICIPANTS A large population-based longitudinal study was conducted in September 2014 using data from the Norwegian Mother and Child Cohort Study conducted at the Norwegian Institute of Public Health from June 1, 1999, to December 31, 2008. A total of 32 662 children or pregnancies were included. EXPOSURES Sleep was assessed by mother-reported child sleep duration and nocturnal awakenings. MAIN OUTCOMES AND MEASURES Emotional and behavioral problems were measured with items from the Child Behavior Checklist and operationalized according to recommended clinical cutoffs, corresponding to T scores of greater than 65 (93rd percentile). Risk ratios (RRs) were calculated using negative binomial regression, controlling for emotional and behavioral problems at 18 months and other relevant covariates. RESULTS Short sleep duration (≤10 hours) in 556 children (1.7%) and frequent nocturnal awakenings (≥3 times) in 1033 children (3.2%) at 18 months significantly predicted both concurrent and later incidence of emotional and behavioral problems at 5 years. The longitudinal RRs were generally larger for internalizing problems, with adjusted RRs of 1.59 (95% CI, 1.23-2.08) for both short sleep duration and 1.57 (95% CI, 1.28-1.93) for nocturnal awakenings; RRs for externalizing problems were 1.77 (95% CI, 1.37-2.30) and 1.25 (95% CI, 1.00-1.58), respectively. Additional adjustment for emotional and behavioral problems at 18 months slightly reduced the strength of these associations, and all RRs remained significant in the fully adjusted models. CONCLUSIONS AND RELEVANCE Early sleep problems predict later development of emotional and behavioral problems. Intervention studies are needed to examine whether sleep programs targeting early childhood may avert the onset of later adverse outcomes.
The Amalgamation of SVR and ANFIS Models with Synchronized Phasor Measurements for On-Line Voltage Stability Assessment

This paper presents the application of support vector regression (SVR) and adaptive neuro-fuzzy inference system (ANFIS) models that are amalgamated with synchronized phasor measurements for on-line voltage stability assessment. As the performance of SVR model extremely depends on the good selection of its parameters, the recently developed ant lion optimizer (ALO) is adapted to seek for the SVR’s optimal parameters. In particular, the input vector of ALO-SVR and ANFIS soft computing models is provided in the form of voltage magnitudes provided by the phasor measurement units (PMUs). In order to investigate the effectiveness of ALO-SVR and ANFIS models towards performing the on-line voltage stability assessment, in-depth analyses on the results have been carried out on the IEEE 30-bus and IEEE 118-bus test systems considering different topologies and operating conditions. Two statistical performance criteria of root mean square error (RMSE) and correlation coefficient (R) were considered as metrics to further assess both of the modeling performances in contrast with the power flow equations. The results have demonstrated that the ALO-SVR model is able to predict the voltage stability margin with greater accuracy compared to the ANFIS model.
The changing role of ICT competitiveness: the case of the Slovenian hotel sector

The purpose of the article is to survey the role of information and communication technology (ICT) for hotel firm’s competitiveness. Based on competitive advantage factor (CAF) and resource theory, this article empirically tests ICT as one of several possible competitiveness factors. The research is focused on analyse of ICT competitiveness position over time, with special attention to different generations of ICT technologies. An electronic survey instrument has been used to collect Slovenian hotel manager’s opinion on competitiveness resources in 2000 and 2010. Hypothesis testing and cluster analyses has been applied, SPSS was also used. The article's findings indicate that hotels need time to recognise the competitiveness potential of every new resource, and once they start to implement it its importance may change over time. Some firms might be slower in implementing new ICT resources, yet, over time, the resource use converges among the firms. The process is repeated with every new ICT generation. The study informs firms and researchers on practical and research issues forthcoming with ICT progression. Research results directly benefits hotel managers by providing actual information on how to employ different generations of ICT. This contribution is a novel way of connecting a firm’s competitiveness with different web generations over time.
Walking speed adaptation ability of Myzus persicae to different temperature conditions

Abstract Walking speeds were calculated for nine clones of the peach potato aphid Myzus persicae collected from three countries along a latitudinal cline of its European distribution from Sweden to Spain (Sweden, UK and Spain), and the effects of collection origin and intra and intergenerational acclimation were investigated. Walking speeds declined with decreasing temperature, with maximum performance at temperatures closest to acclimation temperature (fastest median walking speed of 5.8 cm min–1 was recorded for clone UK 3, collected from the UK, at 25°C after acclimating to 25°C for one generation). Following acclimation at both 20°C and 25°C, walking ceased (as indicated by median walking speeds of 0.0 cm min–1) at temperatures as high as 7.5°C and 12.5°C. However, acclimation at 10°C enabled mobility to occur to temperatures as low as 0°C. There was no relationship between mobility and latitude of collection, suggesting that large scale mixing of aphids may occur across Europe. However, clonal variation was suggested, with clone UK 3 outperforming the majority of other clones across all temperatures at which mobility was maintained following acclimation at 10°C for one and three generations and at 25°C for one generation. The Scandinavian clones consistently outperformed their temperate and Mediterranean counterparts at the majority of temperatures following acclimation for three generations at 25°C.
A Low-Power Asynchronous Step-Down DC–DC Converter for Implantable Devices

In this paper, we present a fully integrated asynchronous step-down switched capacitor dc-dc conversion structure suitable for supporting ultra-low-power circuits commonly found in biomedical implants. The proposed converter uses a fully digital asynchronous state machine as the heart of the control circuitry to generate the drive signals. To minimize the switching losses, the asynchronous controller scales the switching frequency of the drive signals according to the loading conditions. It also turns on additional parallel switches when needed and has a backup synchronous drive mode. This circuit regulates load voltages from 300 mV to 1.1 V derived from a 1.2-V input voltage. A total of 350 pF on-chip capacitance was implemented to support a maximum of 230-μ W load power, while providing efficiency up to 80%. The circuit validating the proposed concepts was fabricated in 0.13- μm complementary metal-oxide semiconductor technology. Experimental test results confirm the expected functionality and performance of the proposed circuit.
Geometrical Shapes Impact on the Performance of ABS-Based Coreless Inductive Sensors for PD Measurement in HV Power Cables

In this paper, a series of investigations on sensitivity and bandwidth for four types of Rogowski coil (RC) sensors was demonstrated. The proposed RC sensor design using acrylonitrile butadiene styrene material carries the advantages, such as lighter weight, robust, and higher temperature resistance. The prototype development first was carried out with the assistance of Solidwork 3D computer aided design software and MakerBot 2X 3D printer. Subsequently, the sensors were modeled and simulated using electromagnetic transient program-alternative transient program software environment based on the lumped parameter identification. A single-end measuring technique was used to locate the PD signal on the three-phase medium voltage underground cross-link polyethylene insulated power cable with a 240-mm2 nominal area copper conductor. In order to verify the results achieved from the simulation, an experiment was carried out. This experiment was repeated concurrently for each design of the RC sensors. In order to achieve the best PD detection, the precise selection for the best sensor is paramount. In this case, the results indicated that certain geometrical shape performed better with regard to the detection of the PD signal.
Doppler images of heterogeneous gel dosimeter phantom by multi-frequency vibration

Vibrating biological tissue by external forces and investing of the induced micro-displacements of internal structures is a powerful technique to map relative mechanical properties within the medium. In general, pathological tissue has the stiffness modified. It implies that the range of resonance frequencies and the amplitudes of vibration of pathological tissues may differ from that of normal tissue. In this work, we propose a new apparatus to apply mechanical vibrations to the internal structure of soft tissue. It consists of a permanent magnet disc placed on the sample and a magnetized coil placed close to the magnet. Appling an alternating current in this coil, the oscillating magnetic field will vibrate the magnet. The vibration profile distribution of the internal structures is detected by ultrasound Doppler images. The contrast in the images of tissue-mimicking phantoms is strongly related with the frequency of vibration. The measurements were performed in a gel phantom containing a cylindrical inclusion two times stiffer than the background and in a dosimeter gel phantom containing a stiff inclusion created by ionizing radiation.
Physical inactivity is associated with earlier mortality--the evidence is incontrovertible.

We commend BJGP for publishing and bringing much needed attention to the opinions of Mike Fitzpatrick on the perceptions of physical activity promotion within the healthcare sector in this country.1 There is, however, nothing virtuous, propagandist, patronising, and infantile about physical inactivity being the fourth leading risk factor for global mortality responsible for 6% of worldwide deaths and a major contributing factor to 60% of global non-communicable diseases.2 There is a clear causal relationship between the amount of movement people do and all-cause mortality. …
Color Constant Color Indexing

Objects can be recognized on the basis of their color alone by color indexing, a technique developed by Swain-Ballard (1991) which involves matching color-space histograms. Color indexing fails, however, when the incident illumination varies either spatially or spectrally. Although this limitation might be overcome by preprocessing with a color constancy algorithm, we instead propose histogramming color ratios. Since the ratios of color RGB triples from neighboring locations are relatively insensitive to changes in the incident illumination, this circumvents the need for color constancy preprocessing. Results of tests with the new color-constant-color-indexing algorithm on synthetic and real images show that it works very well even when the illumination varies spatially in its intensity and color. >
Congenital Podocytopathy with Podocyte Loss and Glomerular Crescents: A Case Report in a Preterm Newborn

Podocytes, also known as glomerular visceral epithelial cells, are highly renal specialized cells leaving between them slit diaphragms that ensure the integrity of the renal basement membrane, playing a major role in establishing a size-selective barrier to protein loss. The reduction in podocyte number represents an important determinant of progressive impairment of the glomerular function that leads to the development of massive proteinuria and ultimately to renal scarring. Podocytopathies are generally considered typical of childhood and adulthood. Here we report a case of podocyte loss presenting in a newborn, prospecting the hypothesis that podocytopathies could start in the perinatal period or, putatively, in the intrauterine life.
Tcl-DP Name Server

This paper describes a general purpose name server for Tcl-DP. This name server maintains host addresses and port numbers of services running in a distributed environment and allows clients to query about them. It starts services on demand so services are guaranteed to be available, and it provides a simple authentication protocol for better security. The Tcl-DP name server is also designed to be fault-tolerant. Multiple backup servers can be started on different hosts, and a failover occurs when the main server goes down. In addition, the name server provides mechanisms to interface with external modules for extending its functionality.
Analysis and design of ultra-low power subthreshold MCML gates

In this paper, ultra-low power current-mode subthreshold MOS Current-mode Logic (MCML) gates are discussed from a modeling and design perspective. A detailed analysis of the DC characteristics is presented, and the effect of process variations is analyzed in depth. Analysis allows for understanding the main limits of sub-threshold MCML gates in terms of delay/power variability. In particular, it is shown that process variations strongly affect the DC characteristics, and moderately impact delay and power consumption. Interestingly, delay and power variations are shown to be significantly reduced compared to typical values encountered in standard subthreshold CMOS logic. Criteria to size transistors to keep variations within assigned bounds are also derived. Results of Monte Carlo simulations with a 65-nm CMOS technology are reported to validate theoretical results.