Miracle-dz/UniFAR-FTUs huggingface dataset:
Measurement of spiritual well-being: a hospice caregiver sample.

This is a methodological study designed to assess the reliability and validity of Paloutzian and Ellison's (1982) Spiritual Well-being Scale. The scale was administered to 70 family members caring for a terminally ill relative. The 20 item measure yields three scores: spiritual well-being (overall score), existential well-being and religious well-being (overall score), existential well-being and religious well-being. The Cronbach's alpha coefficients were . 95, . 94, and . 84 respectively. Construct validity of the measure is discussed in relation to Bradburn's Affect Balance Scale, qualitative data obtained during the interviews and a review of relevant literature related to spiritual well-being. Evidence in support of construct validity of the Spiritual Well-being Scale is lacking.
Pathological study of visceral leishmaniasis in a jackal (Canis aureus)

platelet antibodies were detected. These results strongly suggest that these antibodies play a role in causing platelet dysfunction in the acute stage of canine ehrlichiosis, probably by interaction with platelet membrane glycoprotein. However, the fact that significant inhibition of aggregation was recorded in serum samples taken four days after infection from dog 51 in response to ADP and thrombin, and from dog 56 in response to thrombin, at a stage when no anti-platelet antibodies had been detected in their sera (Harrus and others 1996), suggests that an additional aggregationinhibition factor, other than anti-platelet antibodies may also be present in the sera of acutely infected animals. Collagen induces secondary platelet aggregation. Aggregation occurs after a lag period during which platelet stimulation, morphological changes and agonist secretion are taking place (Troy 1988, Zucker 1989). The delay observed in platelet aggregation after the addition of collagen/epinephrine most probably indicates
Modeling and Engineering Constrained Shortest Path Algorithms for Battery Electric Vehicles

We study the problem of computing constrained shortest paths for battery electric vehicles. Because battery capacities are limited, fastest routes are often infeasible. Instead, users are interested in fast routes on which the energy consumption does not exceed the battery capacity. For that, drivers can deliberately reduce speed to save energy. Hence, route planning should provide both path and speed recommendations. To tackle the resulting [Formula: see text]-hard optimization problem, previous work trades correctness or accuracy of the underlying model for practical running times. We present a novel framework to compute optimal constrained shortest paths (without charging stops) for electric vehicles that uses more realistic physical models, while taking speed adaptation into account. Careful algorithm engineering makes the approach practical even on large, realistic road networks: We compute optimal solutions in less than a second for typical battery capacities, matching the performance of previous inexact methods. For even faster query times, the approach can easily be extended with heuristics that provide high quality solutions within milliseconds.
Tropical Ocean Temperatures Over the Past 3.5 Million Years

Birth of the Cool Over the past 4 million years or so, tropical sea surface temperatures have experienced a cooling trend (see the Perspective by Philander). Herbert et al. (p. 1530) analyzed sea surface temperature records of the past 3.5 million years from low-latitude sites spanning the world's major ocean basins in order to determine the timing and magnitude of the cooling that has accompanied the intensification of Northern Hemisphere ice ages since the Pliocene. Martínez-Garcia et al. (p. 1550) found that the enigmatic eastern equatorial Pacific cold tongue, a feature one might not expect to find in such a warm region receiving so much sunlight, first appeared between 1.8 and 1.2 million years ago. Its appearance was probably in response to a general shrinking of the tropical warm water pool caused by general climate cooling driven by changes in Earth's orbit. Tropical sea surface temperatures were controlled more by atmospheric connections to glaciation cycles than by ocean circulation. Determining the timing and amplitude of tropical sea surface temperature (SST) change is an important part of solving the puzzle of the Plio-Pleistocene ice ages. Alkenone-based tropical SST records from the major ocean basins show coherent glacial-interglacial temperature changes of 1° to 3°C that align with (but slightly lead) global changes in ice volume and deep ocean temperature over the past 3.5 million years. Tropical temperatures became tightly coupled with benthic δ18O and orbital forcing after 2.7 million years. We interpret the similarity of tropical SST changes, in dynamically dissimilar regions, to reflect “top-down” forcing through the atmosphere. The inception of a strong carbon dioxide–greenhouse gas feedback and amplification of orbital forcing at ~2.7 million years ago connected the fate of Northern Hemisphere ice sheets with global ocean temperatures since that time.
Accelerating Tooth Movement With Corticotomies: Is It Possible and Desirable?

Accelerating the rate of tooth movement is desirable to patients because it shortens treatment time and also to orthodontists because treatment duration has been linked to an increased risk of gingival inflammation, decalcification, dental caries, and root resorption. Corticotomies, which some orthodontists are currently using to speed up tooth movements, induce a regional acceleratory phenomenon, which provides the biological basis for accelerated tooth movement. Case reports and limited clinical studies show that corticotomies increase rates of tooth movement and decrease treatment duration. The experimental evidence indicates that corticotomies approximately double the amount of tooth movement produced with orthodontic forces. However, the experimental effects are limited to a maximum of 1-2 months in the canine model, suggesting that the effects of corticotomies in humans may be limited to 2-3 months, during which 4-6 mm of tooth movement might be expected to occur. Based on the available literature, performing corticotomies on a routine basis in private practices may not be justified. Controlled clinical studies are required to better understand the treatment and potential iatrogenic effect(s) of corticotomies.
A miniature steerable end-effector for application in an integrated system for computer-assisted arthroscopy

Arthroscopic techniques are very popular in orthopaedic surgery for intervention on articular joints, especially on the knee. From an engineering viewpoint, current arthroscopic techniques can be improved in two ways: a) by augmenting visual information for the surgeon; b) by improving existing instrumentation. In our laboratory we are addressing both problems by developing an integrated system for computer-assisted arthroscopy. In this paper the procedures and instrumentation currently adopted for arthroscopy, and the limitations of both, are described first. Then the main characteristics of the integrated system we are developing are presented. The design requirements for new and better instruments for arthroscopy are discussed in detail and the fabrication and testing of a prototype of shape memory alloy-based actuator developed for steering the distal part of an arthroscope are discussed. The prototype steerable end-effector can rotate of /spl plusmn/90/spl deg/ and exert a maximum force at the tip of about 1N.
Development of a two-sided relativistic jet in Cygnus X-3

We present multi-epoch radio maps of the microquasar Cygnus X-3 obtained with the Very Large Array (VLA). The observations were carried out as a Target-of-Opportunity (ToO) project triggered by a series of strong (>5 Jy) radio outbursts in September 2000. We nd that Cygnus X-3 was well resolved and clearly elongated in the North-South direction at the VLA resolution in the weeks after the triggering events. In particular, the VLA map from our nal epoch of observation perfectly shows the development of a two-sided radio jet extending over 0.05 pc scales. We interpret both the proper motion and the brightness asymmetry between the jet components in the framework of special relativity eects. Assuming a distance of 10 kpc, the true jet velocity that we derive is close to 0:5c with a large angle with the line of sight. The possible connection between the VLA bipolar jets and the elongated one-sided structures observed at milli-arcsecond angular scales is also discussed.
[Ultrasound of stress cholecystitis--diagnosis and differential diagnosis].

A review of the current literature was performed. Many sonomorphologic features are described in literature, but none of these is pathognomonic for AAC. They also can be found in various nonbiliary disorders. For the diagnosis of the acute acalculous cholecystitis it is recommended to combine the findings wall-thickening, hydrops and sludge. The different sonographic features of the wall-thickening as well as anamnestic and clinical datas should be regarded. Computed tomography with i.v. contrast medium offers the highest sensitivity and specificity, but these datas should be proofed by further studies.
Epidemiology and Pathogenesis of Nasal NK/T-Cell Lymphoma: A Mini-Review

Nasal NK/T-cell lymphoma (NKTCL) frequently presents with necrotic, granulomatous lesions in the upper respiratory tract, and usually shows a highly aggressive clinical course. Thus, it was initially included in the clinical condition of lethal midline granuloma. Recently, the disease has been recognized as a neoplastic proliferation of NK/T cells. The disease is much more frequent in Asian and Latin American countries than in Western countries, and is universally associated with Epstein-Barr virus (EBV) infection. Analyses of gene mutations, especially p53 and c-kit, revealed the different frequencies by district. Abnormalities of other genes have also been reported. Case-control studies showed that the exposure to pesticides and chemical solvents could be causative of NKTCL. Further studies including HLA antigen typing of patients is necessary to further clarify the disease mechanism.
Profiling Heparan Sulfate Proteoglycans in Ovarian Carcinoma

: heparan sulfate, proteoglycans, syndecan, glypican, perlecan, ovarian carcinoma, angiogenesis, prognostic factors Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed cell surface and extracellular matrix (ECM) molecules consisting of a core protein covalently attached to the structurally complex glycosaminoglycan, heparan sulfate (HS). While different HSPG family members synthesized by the same cell are likely to contain similar HS sequences[1], the HSPG core protein is critical in determining the localization within membrane microdomains or the ECM, and consequently the physiological role for HS[2]. There are two major classes of cell surface HSPGs: the syndecans and glypicans. The four syndecans are type I transmembrane proteins that carry three to five HS chains at their amino terminus. The family of six glypicans, however, are globular proteins attached to the cell by a glycosylphosphatidylinositol lipid anchor and contain two to four glycanation sites near their C-terminus resulting in close proximity of the decorating HS chains to the plasma membrane[3]. HSPGs are important coreceptors required for signaling by heparin-binding growth factors such as FGF-2 and VEGF, which recognize specific patterns of sulfation within the HS chains. The binding of cytokines to HSPGs regulates the response of cells/tissues to these growth factors and HSPGs, therefore, play key roles in many aspects of tumor biology including invasion, metastasis, and angiogenesis[4,5]. Several studies have examined the expression of single HSPG family members in cancer (summarized in 4,5). Until recently, the only HSPG to have been studied in detail in ovarian cancer was glypican-3, which may act as a negative regulator of growth in the ovary
The regulation of allergy and asthma

Summary: Allergic diseases and asthma are caused by exaggerated T‐helper 2 (Th2)‐biased immune responses in genetically susceptible individuals. Tolerance to allergens is a mechanism that normally prevents such responses, but the specific immunological events that mediate tolerance in this setting are poorly understood. A number of recent studies indicate that regulatory T cells (Tregs) play an important role in controlling such Th2‐biased responses. Tregs involved in regulating allergy and asthma consist of a family of related types of T cells, including natural CD25+ Tregs as well as inducible forms of antigen‐specific adaptive Tregs. Impaired expansion of natural and/or adaptive Tregs is hypothesized to lead to the development of allergy and asthma, and treatment to induce allergen‐specific Tregs could provide curative therapies for these problems.
DNA barcodes from century‐old type specimens using next‐generation sequencing

Type specimens have high scientific importance because they provide the only certain connection between the application of a Linnean name and a physical specimen. Many other individuals may have been identified as a particular species, but their linkage to the taxon concept is inferential. Because type specimens are often more than a century old and have experienced conditions unfavourable for DNA preservation, success in sequence recovery has been uncertain. This study addresses this challenge by employing next‐generation sequencing (NGS) to recover sequences for the barcode region of the cytochrome c oxidase 1 gene from small amounts of template DNA. DNA quality was first screened in more than 1800 century‐old type specimens of Lepidoptera by attempting to recover 164‐bp and 94‐bp reads via Sanger sequencing. This analysis permitted the assignment of each specimen to one of three DNA quality categories – high (164‐bp sequence), medium (94‐bp sequence) or low (no sequence). Ten specimens from each category were subsequently analysed via a PCR‐based NGS protocol requiring very little template DNA. It recovered sequence information from all specimens with average read lengths ranging from 458 bp to 610 bp for the three DNA categories. By sequencing ten specimens in each NGS run, costs were similar to Sanger analysis. Future increases in the number of specimens processed in each run promise substantial reductions in cost, making it possible to anticipate a future where barcode sequences are available from most type specimens.
Place de l’autogreffe de cellules souches hématopoïétiques périphériques dans le traitement de la leucémie lymphoïde chronique

Auteur(s) : Laurent Sutton Service hematologie, Centre hospitalier Victor-Dupouy, 69 rue du Lieutenant-Colonel Prudhon, 95107 Argenteuil Le principe de l’autogreffe, developpe initialement dans le traitement des lymphomes, etait de permettre un traitement potentiellement eradicateur de la maladie, en obtenant une reponse tumorale majeure grâce a l’intensite de la dose de chimiotherapie administree pour depasser une resistance intrinseque de la cellule tumorale [1]. Les resultats [. ]
Interaction of SPIN90 with the Arp2/3 Complex Mediates Lamellipodia and Actin Comet Tail Formation*

The appropriate regulation of the actin cytoskeleton is essential for cell movement, changes in cell shape, and formation of membrane protrusions like lamellipodia and filopodia. Moreover, several regulatory proteins affecting actin dynamics have been identified in the motile regions of cells. Here, we provide evidence for the involvement of SPIN90 in the regulation of actin cytoskeleton and actin comet tail formation. SPIN90 was distributed throughout the cytoplasm in COS-7 cells, but exposing the cells to platelet-derived growth factor (PDGF) caused a redistribution of SPIN90 to the cell cortex and the formation of lamellipodia (or membrane ruffles), both of which were dramatically inhibited in SPIN90-knockdown cells. In addition, the binding of the C terminus of SPIN90 with both the Arp2/3 complex (actin-related proteins Arp 2 and Arp 3) and G-actin activates the former, leading to actin polymerization in vitro. And when coexpressed with phosphatidylinositol 4-phosphate 5 kinase, SPIN90 was observed within actin comet tails. Taken these findings suggest that SPIN90 participates in reorganization of the actin cytoskeleton and in actin-based cell motility.
Effect of Chlorine Dioxide on Lignin Content and Cellulose Digestibility of Forages

Continuous, accurate recording in circulating fluids from a sodium and a potassium electrode is described. The Na electrode is capable of discriminating Δ[Na+] of less than 1 meq/lit. in 140 meq/lit. , and the K electrode is capable of discriminating Δ[K+] of less than 1 meq/lit. in the range of 1 to 10 meq/lit. with good reproducibility. The electrodes may be used singly or in pairs with a common reference calomel electrode for simultaneous monitoring of A [Na+ 1 and Δ[K+] in mixed solutions. Problems of streaming potential dependent on flow rate and electrode shape, as well as transient K+ response by the Na electrode, are discussed.
A tutorial introduction to research on analog and mixed-signal circuit testing

Traditionally, work on analog testing has focused on diagnosing faults in board designs. Recently, with increasing levels of integration, not just diagnosing faults, but distinguishing between faulty and good circuits has become a problem. Analog blocks embedded in digital systems may not easily be separately testable. Consequently, many papers have been recently written proposing techniques to reduce the burden of testing analog and mined-signal circuits. This survey attempts to outline some of this recent work, ranging from tools for simulation-based test set development and optimization to built-in self-test (BIST) circuitry.
Management and Outcome of Fetomaternal Rh Alloimmunization in Twin Pregnancies

Between 1987 and 1996, nine twin pregnancies with fetomaternal Rh alloimmunization were delivered at our institution. Eight pregnancies were dizygotic, and the fetal blood groups were different in 3 cases. The remaining pregnancy was monozygotic and monochorionic-diamniotic. Intravenous fetal exchange transfusion was performed in five pregnancies, up to five times in each twin in one pregnancy. No fetal death occurred. The average gestational age at birth was 35 (range 33–37) weeks. The hemoglobin level was 13.2 (range 9.2–16.5) g/dl. Fetomaternal Rh alloimmunization in twin pregnancy is according to zygosity; each fetus has to be treated separately, except in case of transplacental communication.
Early fruiting in Synsepalum dulcificum (Schumach. & Thonn.) Daniell juveniles induced by water and inorganic nutrient management

Background. The miracle plant, Synsepalum dulcificum (Schumach. & Thonn.) Daniell is a native African orphan crop species that has recently received increased attention due to its promise as a sweetener and source of antioxidants in both the food and pharmaceutical industries. However, a major obstacle to the species’ widespread utilization is its relatively slow growth rate and prolonged juvenile period. Method. In this study, we tested twelve treatments made up of various watering regimes and exogenous nutrient application (nitrogen, phosphorus and potassium, at varying dosages) on the relative survival, growth, and reproductive development of 15-months-old S. dulcificum juveniles. Results. While the plants survived under most tested growing conditions, nitrogen application at doses higher than 1.5 g [seedling] -1 was found to be highly detrimental, reducing survival to 0%. The treatment was found to affect all growth traits, and juveniles that received a combination of nitrogen, phosphorus, and potassium (each at a rate of 1.5 g [seedling] -1), in addition to daily watering, exhibited the most vegetative growth. The simple daily provision of adequate water was found to greatly accelerate the transition to reproductive maturity in the species (from >36 months to an average of 23 months), whereas nutrient application affected the length of the reproductive phase within a season, as well as the fruiting intensity. Conclusions. This study highlights the beneficial effect of water supply and fertilization on both vegetative and reproductive growth in S. dulcificum. Water supply appeared to be the most important factor unlocking flowering in the species, while the combination of nitrogen, phosphorus and potassium at the dose of 1.5 g (for all) consistently exhibited the highest performance for all growth and yield traits. These findings will help intensify S. dulcificum’s breeding and horticultural development.
La calidad de la amistad en alumnado rechazado de 7 y 8 años de edad

La realizacion de esta comunicacion ha sido posible gracias a las ayudas de investigacion concedidas al segundo autor como Investigador principal del Grupo gr ei (Grupo interuniversitario de investigacion del Rechazo entre Iguales en el contexto escolar) por el Ministerio de Economia y Competitividad (Proyecto: Estudio longitudinal multicomponente y multiagente para optimizar la inclusion del alumnado rechazado por sus companeros en los cursos superiores de la educacion primaria; Referencia edu2012-35930), por la Fundacion Bancaja-Universitat Jaume I (Proyecto: Programa longitudinal, multicomponente y multiagente para el aprendizaje de la amistad de ninos y ninas rechazados de 8-11 anos en un contexto interpersonal positivo; Referencia p1-1a2012-04) y por la Fundacion Davalos-Fletcher de Castellon (Proyecto: El Rechazo entre Iguales en su Contexto Interpersonal: Una Investigacion con ninos y ninas de Primer Ciclo de Primaria; convocatoria de 2009).
Essentials of the Theory of Fiction

What accounts for the power of stories to both entertain and illuminate? This question has long compelled the attention of storytellers and students of literature alike, and over the past several decades it has opened up broader dialogues about the nature of culture and interpretation. This third edition of the bestselling Essentials of the Theory of Fiction provides a comprehensive view of the theory of fiction from the nineteenth century through modernism and postmodernism to the present. It offers a sample of major theories of fictional technique while emphasizing recent developments in literary criticism. The essays cover a variety of topics, including voice, point of view, narration, sequencing, gender, and race. Ten new selections address issues such as oral memory in African American fiction, temporality, queer theory, magical realism, interactive narratives, and the effect of virtual technologies on literature. For students and generalists alike, Essentials of the Theory of Fiction is an invaluable resource for understanding how fiction works. Contributors. M. M. Bakhtin, John Barth, Roland Barthes, Wayne Booth, John Brenkman, Peter Brooks, Catherine Burgass, Seymour Chatman, J. Yellowlees Douglas, Rachel Blau DuPlessis, Wendy B. Faris, Barbara Foley, E. M. Forster, Joseph Frank, Joanne S. Frye, William H. Gass, Henry Louis Gates Jr., Gerard Genette, Ursula K. Heise, Michael J. Hoffman, Linda Hutcheon, Henry James, Susan S. Lanser, Helen Lock, Georg Lukacs, Patrick D. Murphy, Ruth Ronen, Joseph Tabbi, Jon Thiem, Tzvetan Todorov, Virginia Woolf