Miracle-dz/UniFAR-FTUs huggingface dataset:
Massive MIMO With Ternary ADCs

Massive multiple-input-multiple-output (MIMO) system inevitably faces the hardware cost and energy efficiency problem due to its large number of antennas at the base station (BS). The use of low-resolution analog-to-digital converters (ADCs), e.g., typical 1-bit ADCs, can effectively reduce the system cost. In this paper, we consider a massive MIMO uplink with ternary/three level ADCs. The design of typical linear combiner based detectors is given along with their analytical symbol-error-rate (SER) performance results. Analytical and simulation results show that 1) ternary ADCs can effectively compensate the SER performance gap between 1-bit and full-resolution ADCs; 2) optimal design of ternary ADCs for SER minimization can be referred to the existing design for quantization error minimization; 3) ternary ADCs perform better than 2-bit ADCs in energy efficiency. Thus, for some low-cost scenarios where implementing 2-bit ADCs for each antenna in massive MIMO may be even unaffordable, ternary ADC can be a good choice.
HyDetect: A Hybrid CPU-GPU Algorithm for Community Detection

Community detection is an important problem that is widely applied for finding cluster patterns in brain, social, biological and many other kinds of networks. In this work, we propose a divide-and-conquer community detection algorithm for hybrid CPU-GPU systems. The graph representing a network is partitioned among the CPU and GPU devices of a node, and independent community detection using Louvain's algorithm is carried out in both the parts. The communities are iteratively refined by a novel strategy for identifying and moving "doubtful" vertices between the devices. The resulting accuracy is found comparable with the single device parallel Louvain algorithms. Our hybrid algorithm helped to explore large graphs that cannot be accommodated in a single device. By harnessing the power of GPUs, our hybrid algorithm is able to provide 42-73% smaller execution times over state-of-art CPU-only algorithms.
SIPSA: Secure IoT Protocol-Based Smart Adapter for Communicating and Optimizing Building Energy Management with Smart Grid

Old buildings often suffer from poor energy management and lacking of good internal communication, which leads to suboptimal operation efficiency and reliability. This paper describes a system named SIPSA (Secure IoT Protocol-Based Smart Adapter) for communicating and optimizing building energy management with smart grid. SIPSA works in parallel with the building systems to continuously conduct communication and optimization at the multiple stages in the system workflow and provide real-time actions for efficiency improvement.
A General Methodology for Beached Oil Spill Hazard Mapping

The current lack of a standardized approach to compute the coastal oil spill hazard due to maritime traffic accidental releases has hindered an accurate estimate of its global impact, which is paramount to manage and intercompare the associated risks. We propose here a hazard estimation approach that is based on ensemble simulations and the extraction of the relevant distributions. We demonstrate that both open ocean and beached oil concentration distributions fit a Weibull curve, a two-parameter fat-tail probability distribution function. The simulation experiments are carried out in three different areas of the northern Atlantic. An indicator that quantify the coastal oil spill hazard is proposed and applied to the study areas.
Modeling the Impact of Microgravity at the Cellular Level: Implications for Human Disease

A lack of gravity experienced during space flight has been shown to have profound effects on human physiology including muscle atrophy, reductions in bone density and immune function, and endocrine disorders. At present, these physiological changes present major obstacles to long-term space missions. What is not clear is which pathophysiological disruptions reflect changes at the cellular level versus changes that occur due to the impact of weightlessness on the entire body. This review focuses on current research investigating the impact of microgravity at the cellular level including cellular morphology, proliferation, and adhesion. As direct research in space is currently cost prohibitive, we describe here the use of microgravity simulators for studies at the cellular level. Such instruments provide valuable tools for cost-effective research to better discern the impact of weightlessness on cellular function. Despite recent advances in understanding the relationship between extracellular forces and cell behavior, very little is understood about cellular biology and mechanotransduction under microgravity conditions. This review will examine recent insights into the impact of simulated microgravity on cell biology and how this technology may provide new insight into advancing our understanding of mechanically driven biology and disease.
Implementation of an Early Childhood Healthy Eating and Physical Activity Program in New South Wales, Australia: Munch & Move

Background: Childhood obesity is an important public health issue. Approximately 20% of 2–4 year olds are overweight or obese, meaning 1 in 5 Australian children start school above a healthy weight. In the state of New South Wales (NSW) the combined prevalence of childhood overweight and obesity is significantly higher among children from low socioeconomic status backgrounds and children from regional, rural and remote areas. This paper describes implementation of a healthy eating and active play program (Munch & Move) for center-based early childhood education and care (ECEC) services aimed at influencing healthy behaviors in young children in NSW, Australia. It shows changes over time including a focus on disadvantaged, Aboriginal and remote communities. It also discusses the challenges and future opportunities for the program. Methods: Routine data in relation to service delivery (reach) and implementation indicators are collected by Local Health District staff. Fifteen implementation indicators (known as practices) were introduced to monitor the implementation of Munch & Move (six related to promoting and encouraging healthy eating, four related to improving physical activity, two related to small screen recreation; and three related to quality of service delivery). Results: As of 30 June 2017, 88.4% of ECEC services have staff trained in Munch & Move. Of the 15 practices related to promoting and encouraging healthy eating, increasing physical activity and improving the quality of service delivery 13 practices saw significant improvements between 2012 and 2017. This was consistent for services with a high proportion of Aboriginal children and for services in disadvantaged and remote communities. There has been a statistically significant increase in the proportion (37.6–81.0%, p < 0.0001) and type of ECEC services (preschools 36.1–81.3%, p < 0.0001, long day care 38.6–81.0%, p < 0.0001, and occasional care 34.0–74.6%, p < 0.0001) that have implemented the program since 2012 as well as in services with a high proportion of Aboriginal children (33.6–85.2% p < 0.0001), services in disadvantaged communities (37.4–83.3% p < 0.001), and services in remote communities (27.8–59.4% p < 0.0139). Discussion: This paper demonstrates that Munch & Move has seen large improvements in the delivery of training, practice achievements and program adoption in ECEC services across NSW including services in disadvantaged and remote communities and that have a higher proportion of Aboriginal children.
Unleashing Natural Killer Cells in the Tumor Microenvironment–The Next Generation of Immunotherapy?

The emergence of immunotherapy for cancer treatment bears considerable clinical promise. Nevertheless, many patients remain unresponsive, acquire resistance, or suffer dose-limiting toxicities. Immune-editing of tumors assists their escape from the immune system, and the tumor microenvironment (TME) induces immune suppression through multiple mechanisms. Immunotherapy aims to bolster the activity of immune cells against cancer by targeting these suppressive immunomodulatory processes. Natural Killer (NK) cells are a heterogeneous subset of immune cells, which express a diverse array of activating and inhibitory germline-encoded receptors, and are thus capable of directly targeting and killing cancer cells without the need for MHC specificity. Furthermore, they play a critical role in triggering the adaptive immune response. Enhancing the function of NK cells in the context of cancer is therefore a promising avenue for immunotherapy. Different NK-based therapies have been evaluated in clinical trials, and some have demonstrated clinical benefits, especially in the context of hematological malignancies. Solid tumors remain much more difficult to treat, and the time point and means of intervention of current NK-based treatments still require optimization to achieve long term effects. Here, we review recently described mechanisms of cancer evasion from NK cell immune surveillance, and the therapeutic approaches that aim to potentiate NK function. Specific focus is placed on the use of specialized monoclonal antibodies against moieties on the cancer cell, or on both the tumor and the NK cell. In addition, we highlight newly identified mechanisms that inhibit NK cell activity in the TME, and describe how biochemical modifications of the TME can synergize with current treatments and increase susceptibility to NK cell activity.
Mucosal Heterologous Prime/Boost Vaccination Induces Polyfunctional Systemic Immunity, Improving Protection Against Trypanosoma cruzi

There are several unmet needs in modern immunology. Among them, vaccines against parasitic diseases and chronic infections lead. Trypanosoma cruzi, the causative agent of Chagas disease, is an excellent example of a silent parasitic invasion that affects millions of people worldwide due to its progression into the symptomatic chronic phase of infection. In search for novel vaccine candidates, we have previously introduced Traspain, an engineered trivalent immunogen that was designed to address some of the known mechanisms of T. cruzi immune evasion. Here, we analyzed its performance in different DNA prime/protein boost protocols and characterized the systemic immune response associated with diverse levels of protection. Formulations that include a STING agonist, like c-di-AMP in the boost doses, were able to prime a Th1/Th17 immune response. Moreover, comparison between them showed that vaccines that were able to prime polyfunctional cell-mediated immunity at the CD4 and CD8 compartment enhanced protection levels in the murine model. These findings contribute to a better knowledge of the desired vaccine-elicited immunity against T. cruzi and promote the definition of a vaccine correlate of protection against the infection.
Post-Transcriptional Dysregulation of microRNA and Alternative Polyadenylation in Colorectal Cancer

Background Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. microRNAs (miRNAs) repress gene expression by binding to complementary sequences in the 3' untranslated region (3'UTR) of target mRNAs. Alternative polyadenylation (APA) are relevant to the variability of the 3'UTR of mRNA. However, the posttranscriptional dysregulation of miRNAs and APA in CRC are poorly understood. Method In this study, we conducted small RNA sequencing to identify differentially expressed miRNAs (DERs) and their target genes. Function analysis on DER-target genes can explain the regulation roles of miRNAs in CRC. The mutual regulation of miRNAs and APA was analyzed by combining miRNA data to 3'UTR alteration using 3' termini of polyadenylated RNAs sequencing (3T-seq) technique, and this was validated using TCGA gene expression data. Results Our results showed 64 significant differentially expressed miRNAs (DERs) in CRC patients. Their target genes were related to cell adhesion and transcription regulation and were prevailingly involved in the CRC-related pathway. Integrative analysis of the miRNA and APA profile revealed 16 DERs were correlated with 12 polyadenylation factors, and six of them were significantly differently expressed in CRC. We also found four DERs that lost binding sites due to APA and showed a positive correlation between the miRNA and gene expression. Conclusion Our study found that miRNAs regulated APA by modulating key polyadenylation factors, and several miRNAs lost their suppression on mRNA due to APA. Associating this with gene expression may provide some important clues for a deeper study of posttranscriptional cellular regulation and biomarker research in CRC. Our data provided the first evidence that the interaction between miRNAs and APA associated with gene expression could serve as biomarkers for CRC, suggesting that hsa-miR-133a-3p and MLEC, hsa-miR-145-5p and SET, hsa-miR-1-3p and PPIA, and hsa-miR-378d and YY1 might be novel and potential biomarkers in improving the diagnosis of CRC.
Epicardial Fibrosis Explains Increased Endo–Epicardial Dissociation and Epicardial Breakthroughs in Human Atrial Fibrillation

Background Atrial fibrillation (AF) is accompanied by progressive epicardial fibrosis, dissociation of electrical activity between the epicardial layer and the endocardial bundle network, and transmural conduction (breakthroughs). However, causal relationships between these phenomena have not been demonstrated yet. Our goal was to test the hypothesis that epicardial fibrosis suffices to increase endo–epicardial dissociation (EED) and breakthroughs (BT) during AF. Methods We simulated the effect of fibrosis in the epicardial layer on EED and BT in a detailed, high-resolution, three-dimensional model of the human atria with realistic electrophysiology. The model results were compared with simultaneous endo–epicardial mapping in human atria. The model geometry, specifically built for this study, was based on MR images and histo-anatomical studies. Clinical data were obtained in four patients with longstanding persistent AF (persAF) and three patients without a history of AF. Results The AF cycle length (AFCL), conduction velocity (CV), and EED were comparable in the mapping studies and the simulations. EED increased from 24.1 ± 3.4 to 56.58 ± 6.2% (p < 0.05), and number of BTs per cycle from 0.89 ± 0.55 to 6.74 ± 2.11% (p < 0.05), in different degrees of fibrosis in the epicardial layer. In both mapping data and simulations, EED correlated with prevalence of BTs. Fibrosis also increased the number of fibrillation waves per cycle in the model. Conclusion A realistic 3D computer model of AF in which epicardial fibrosis was increased, in the absence of other pathological changes, showed increases in EED and epicardial BT comparable to those in longstanding persAF. Thus, epicardial fibrosis can explain both phenomena.
Potential Roles of Exosomes in Parkinson’s Disease: From Pathogenesis, Diagnosis, and Treatment to Prognosis

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease in the world, after Alzheimer’s disease (AD), affecting approximately 1% of people over 65 years of age. Exosomes were once considered to be cellular waste and functionless. However, our understanding about exosome function has increased, and exosomes have been found to carry specific proteins, lipids, functional messenger RNAs (mRNAs), high amounts of non-coding RNAs (including microRNAs, lncRNAs, and circRNAs) and other bioactive substances. Exosomes have been shown to be involved in many physiological processes in vivo, including intercellular communication, cell migration, angiogenesis, and anti-tumor immunity. Moreover, exosomes may be pivotal in the occurrence and progression of various diseases. Therefore, exosomes have several diverse potential applications due to their unique structure and function. For instance, exosomes may be used as biological markers for the diagnosis and prognosis of various diseases, or as a natural carrier of drugs for clinical treatment. Here, we review the potential roles of exosomes in the pathogenesis, diagnosis, treatment, and prognosis of PD.
Lithiophilic Silver Coating on Lithium Metal Surface for Inhibiting Lithium Dendrites

Li metal batteries (LMBs) are known as the ideal energy storage candidates for the future rechargeable batteries due to the high energy density. However, uncontrolled Li dendrites growing during charge/discharge process causes extremely low coulombic efficiency and short lifespan. In this work, a thin lithiophilic layer of Ag was coated on the bare Li surface via a thermal evaporation method, which alleviated volume variations and suppressed Li dendrites growth during cycling. As a result, a long lifespan of 250 h at a current density of 1 mA cm−2 was achieved in the symmetric cell when using the Ag-modified Li foil (Ag@Li). The LiFePO4|Li full cell demonstrated an excellent cycling performance with a high specific capacity of 131 mAh g−1 even after 300 cycles at 0.5 C. This study offers a suitable method for stabilizing Li metal anodes in LMBs.
Do Brand Competence and Warmth Always Influence Purchase Intention? The Moderating Role of Gender

Consumers’ perceptions of a brand (e.g., competence or warmth) may directly affect their brand trust, purchase intention, and ability to achieving corporate goals of sustainability. However, gender acts as a moderator in the influence of brand perception on purchase intention. This study examined the main effects of brand perception on purchase intention, the moderating effect of gender, and the mediating effect of brand trust by conducting two experiments and a path analysis. Findings from experiment 1 show that perceived warmth and perceived competence exert significant positive effects on purchase intention with brand trust as a mediator. Findings from experiment 2 indicate that perceived warmth is influential only for female customers, not for male customers, that is, gender moderates the relationship between perceived warmth and purchase intention. However, gender does not moderate the influence of perceived competence on purchase intention. The results of the path analysis are consistent with the experimental results, indicating that the conclusions of the study are robust and reliable. Finally, theoretical contributions and managerial implications are discussed.
Social Networks Use Disorder and Associations With Depression and Anxiety Symptoms: A Systematic Review of Recent Research in China

Background: An increasing number of studies have investigated Social Networks Use Disorder (SNUD) among Western samples. In this context, the investigation of SNUD in Asia and especially in China has been much neglected. This poses a gap in the literature; it has been estimated that more than one billion Chinese people are using Chinese social networking sites (SNSs). Of note, many of these Chinese SNSs are rather unknown to researchers in Western countries. Aims: The primary objective of the present systematic review was to identify and evaluate studies that investigated Chinese SNS use and associations between SNUD and depression and anxiety symptoms. Method: A comprehensive search strategy identified relevant studies in PsycINFO, PsycARTICLES, Psychology and Behavioral Sciences Collection, MEDLINE, ProQuest, Web of Science, PubMed, Google Scholar, and the Chinese National Knowledge Infrastructure database (CNKI). Results: The search strategy identified 35 potential studies, 13 studies were identified after shortlisting and full-text reviews of the studies, and finally 10 studies were included in the full review. Associations between SNUD, depression, and anxiety were reported in 10 studies. In eight (of the 10) studies, symptom severity of SNUD was associated with depression. Four studies reported associations between SNUD and anxiety. Most studies had utilized cross-sectional survey designs. Conclusions: Most associations were found between SNUD and depression symptoms, but effect sizes were higher between SNUD and anxiety symptoms. The results have the potential to inform prevention and interventions on SNUD in Eastern cultures, although we explicitly state that our work focuses on China, the transfer of the present observations to other Asian countries (and their cultures) still needs to be established.
Splicing Characterization of CLCNKB Variants in Four Patients With Type III Bartter Syndrome

Objective Type III Bartter syndrome (BS) is caused by loss-of-function mutations in the gene encoding basolateral chloride channel ClC-Kb (CLCNKB), and is characterized by hypokalemic metabolic alkalosis and hyperreninemic hyperaldosteronism. Here, we investigated the molecular defects in four Chinese children with clinical manifestations of Bartter syndrome. Methods The genomic DNA of the four patients was screened for gene variations using whole-exome sequencing (WES). The candidate variants were validated by direct Sanger sequencing. Quantitative PCR (qPCR) was subsequently performed to confirm the whole CLCNK gene deletion mutation. A minigene assay and reverse transcription PCR (RT-PCR) were performed to analyze the effect of splice variants in vitro. Results Our patients showed early onset age with hyponatremia, hypokalemia, hypochloremia, repeated vomiting and growth retardation, suggesting Bartter syndrome. Genetic analysis revealed that all patients carried compound heterozygous or homozygous truncating variants in the CLCNKB gene. In particular, we identified a novel nonsense variant c.239G > A (p.(Trp80*)), two splice site variants (c.1053-1 G > A and c.1228-2A > G), a whole gene deletion, and a novel synonymous variant c.228A > C (p.(Arg76Arg)) which located -2 bp from the 5′ splice donor site in exon 3. Furthermore, our in vitro minigene analysis revealed c.228A > C, c.1053-1G > A, and c.1228-2A > G cause the skipping of exon 3, exon 12, and exon 13, respectively. Conclusion Our results support that the whole CLCNKB gene deletion is the most common mutation in Chinese patients with type III BS, and truncating and whole gene deletion variants may account for a more severe phenotype of patients. We verified the pathogenic effect of three splicing variants (c.228A > C, c.1053-1G > A, and c.1228-2A > G) which disturbed the normal mRNA splicing, suggesting that splice variants play an important role in the molecular basis of type III BS, and careful molecular profiling of these patients will be essential for future effective personalized treatment options.
Fusobacterium nucleatum Activates Endoplasmic Reticulum Stress to Promote Crohn’s Disease Development via the Upregulation of CARD3 Expression

There is increasing evidence that members of the gut microbiota, especially Fusobacterium nucleatum (F. nucleatum), are associated with Crohn’s disease (CD), but the specific mechanism by which F. nucleatum promotes CD development is unclear. Here, we first examined the abundance of F. nucleatum and its effects on CD disease activity and explored whether F. nucleatum aggravated intestinal inflammation and promoted intestinal mucosal barrier damage in vitro and in vivo. Our data showed that F. nucleatum was enriched in 41.21% of CD tissues from patients and was correlated with the clinical course, clinical activity, and refractory behavior of CD (P < 0.05). In addition, we found that F. nucleatum infection is involved in activating the endoplasmic reticulum stress (ERS) pathway during CD development to promote intestinal mucosal barrier destruction. Mechanistically, F. nucleatum targeted caspase activation and recruitment domain 3 (CARD3) to activate the ERS pathway and promote F. nucleatum-mediated mucosal barrier damage in vivo and in vitro. Thus, F. nucleatum coordinates a molecular network involving CARD3 and ERS to control the CD process. Measuring and targeting F. nucleatum and its associated pathways will provide valuable insight into the prevention and treatment of CD.