Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical phenotypes and outcomes of pulmonary hypertension due to left heart disease: Role of the pre-capillary component

Background In pulmonary hypertension (PH), both wedge pressure elevation (PAWP) and a precapillary component may affect right ventricular (RV) afterload. These changes may contribute to RV failure and prognosis. We aimed at describing the different haemodynamic phenotypes of patients with PH due to left heart disease (LHD) and at characterizing the impact of pulmonary haemodynamics on RV function and outcome PH-LHD. Methods Patients with PH-LHD were compared with treatment-naïve idiopathic/heritable pulmonary arterial hypertension (PAH, n = 35). PH-LHD patients were subdivided in Isolated post-capillary PH (IpcPH: diastolic pressure gradient, DPG<7 mmHg and pulmonary vascular resistance, PVR≤3 WU, n = 37), Combined post- and pre-capillary PH (CpcPH: DPG≥7 mmHg and PVR>3 WU, n = 27), and “intermediate” PH-LHD (either DPG <7 mmHg or PVR ≤3 WU, n = 29). Results Despite similar PAWP and cardiac index, haemodynamic severity and prevalence of RV dysfunction increased from IpcPH, to “intermediate” and CpcPH. PVR and DPG (but not compliance, Ca) were linearly correlated with RV dysfunction. CpcPH had worse prognosis (p<0.05) than IpcPH and PAH, but similar to “intermediate” patients. Only NTproBNP and Ca independently predicted survival in PH-LHD. Conclusions In PH-LHD, haemodynamic characterization according to DPG and PVR provides important information on disease severity, predisposition to RV failure and prognosis. Patients presenting the CpcPH phenotype appear to have haemodynamic profile closer to PAH but with worse prognosis. In PH-LHD, Ca and NTproBNP were independent predictors of survival.
Non-Intrusive Energy Use Monitoring for a Group of Electrical Appliances

Energy use monitoring techniques are useful to home and facility owners, enabling them to save energy and reduce costs. The monitoring methods published so far are focused on detecting individual appliances and determining their respective energy consumption. This paper proposes a method for estimating the energy use of a group of appliances with similar electrical characteristics and operation patterns. The proposed method consists of two steps. The first step is to determine the probability that a given electrical event is caused by a member of the appliance group of interest. The second step analytically estimates the mean value and standard deviation of the total energy use of the appliance group based on the combination of Bernoulli distributions. Case studies using both simulations and field measurements have shown that the proposed method is able to accurately detect power and energy for a given group of appliances. It fills an important gap in non-intrusive energy use monitoring research for homes and facilities.
Secondary School Students' Socio Economic Status, Mathematics Self-Concept and Achievement Goal Orientations: A Correlational Investigation.

This study was aimed at finding relationship among students’ mathematics Self-concept, Socio Economic Status (SES) and Achievement Goal Orientations (AGOs) at secondary level in Punjab. The population of study included secondary school students in the Punjab province. The sample was selected through multi-stage random sampling technique. An adapted questionnaire was used to get responses about achievement goal orientation of students. Mathematics Self-concept scale by Marsh (1948) was used to know students’ academic selfconcept. "Socio Economic" Status was assessed through different demographic variables. Through SPSS, Pearson correlation coefficient was run to calculate correlation among students' self-concept in mathematics, SES, and their AGOs. Results showed significant correlation between students’ self concept in mathematics and their AGOs. Correlation between SES and AGOs of students was not significant. On the basis of findings, it was recommended that teachers should use instructional strategies which tend to improve students' mathematics "self concept" to make them mastery goal oriented.
Number 206 Sodium and Potassium Intake : Effects on Chronic Disease Outcomes and Risk s Evidence Summary

Cardiovascular disease (CVD) and kidney disease are responsible for the majority of deaths worldwide. A primary risk factor for CVD (cardiovascular disease), stroke, and other circulatory diseases is hypertension (HTN). In November 2017, the American Heart Association and the American College of Cardiology modified the definition of hypertension to a systolic blood pressure of 130 or higher and a diastolic blood pressure of 80 or higher. Before issue of the 2017 report on which these changes were based, health organizations worldwide defined hypertension as a systolic blood pressure (BP) of 140 or higher or a diastolic BP of 90 or higher; however, for the purpose of this review, the definition of HTN is that used by the individual included studies.
Treatment of Lymphatic Malformations with the mTOR Inhibitor Sirolimus: A Systematic Review.

BACKGROUND Extensive lymphatic malformations are low-flow vascular malformations that can cause devastating complications. Treatment of these malformations is challenging. This systematic review presents current use of sirolimus in patients with extensive lymphatic malformations. METHODS MEDLINE and Google scholar search was conducted for studies on sirolimus treatment of lymphatic malformations up to July 2017. Search items included "lymphatic malformation," "lymphangioma," "cystic hygroma," "vascular malformation," "low-flow malformation," "sirolimus," "rapamycin," and "mTOR inhibitor. " RESULTS Twenty studies, including 71 patients receiving sirolimus, were included into this review. Forty-five patients had lymphatic malformations, eight patients venolymphatic malformations, and 19 patients capillary-lymphatico-venous malformations. Sirolimus led to a partial remission of disease in 60 patients, three patients had a progressive disease, and the outcome of eight patients was not reported. Dosing, target trough level, and duration of treatment differed between the studies. Common adverse effects were hyperlipidemia and neutropenia. CONCLUSIONS Available literature indicated that sirolimus therapy might be effective for lymphatic malformations. However, further randomized controlled studies are required to analyze the efficacy and long-term adverse events and to clarify the potential role for sirolimus in the management of lymphatic malformations.
Primary Immunodeficiencies Unravel the Role of IL-2/CD25/STAT5b in Human Natural Killer Cell Maturation

Natural killer (NK) cells play a pivotal role during immunity against viruses and circumstantial evidence also indicates that they can protect the host against developing tumors. Peripheral blood NK cells comprise CD56brightCD16lo/− cells that constitutively express CD25 (IL-2Rα) and CD56dimCD16hi cells that express CD25 upon activation. Using NK cells from two patients, one with a primary immunodeficiency characterized by a homozygous mutation in CD25 (born in year 2007 and studied since she was 3 years old) and one with a homozygous mutation in STAT5b (born in year 1992 and studied since she was 10 years old), we observed that the absence of IL-2 signaling through CD25 promotes the accumulation of CD56brightCD16high NK cells, and that CD56brightCD16lo, CD56brightCD16high, and CD56dimCD16high NK cells of this patient exhibited higher content of perforin and granzyme B, and proliferation capacity, compared to healthy donors. Also, CD56bright and CD56dim NK cells of this patient exhibited a reduced IFN-γ production in response to cytokine stimulation and increased degranulation against K562 cells. Also, the CD25-deficient patient presented a lower frequency of terminally differentiated NK cells in the CD56dimCD16hi NK subpopulation compared to the HD (assessed by CD57 and CD94 expression). Remarkably, CD56dimCD16high NK cells from both patients exhibited notoriously higher expression of CD62L compared to HD, suggesting that in the absence of IL-2 signaling through CD25 and STAT5b, NK cells fail to properly downregulate CD62L during their transition from CD56brightCD16lo/− to CD56dimCD16hi cells. Thus, we provide the first demonstration about the in vivo requirement of the integrity of the IL-2/CD25/STAT5b axis for proper human NK cell maturation.
Efficient Partial-Sum Network Architectures for List Successive-Cancellation Decoding of Polar Codes

List successive cancellation decoder (LSCD) architectures have been recently proposed for the decoding of polar codes to achieve high decoding performance. However, the existing architectures for updating the partial sums of all the list candidate paths scale linearly with the code length and hence have significant area and delay overhead for polar codes with long code length or list size. In this paper, a list high-performance partial-sum network (LHPPSN) is proposed based on a folded partial-sum network (PSN) architecture of which the complexity does not scale with the code length. A design based on replicating units of high-performance PSN and lazy copying is first presented. To improve the area and performance, a new method based on indices copying is proposed next. In addition, by exploiting the properties of PSN, the complexity is further reduced by sharing the path copying logic. Experimental results show that using the proposed LHPPSN results in more than 70% and 40% reduction in area and delay, respectively, for polar codes with large code length or list size, when compared with the state-of-the-art LSCD PSN architectures.
The Relationship Between Growth and Economic Complexity: Evidence from Southeastern and Central Europe

The index of economic complexity is created by analyzing the relations between countries and the products they export. Constructed in such way, it defines the basis for the theory of economic complexity, which reflects the knowledge embedded in the productive structure of an economy. Exactly this knowledge is at the core of the endogenous theory of economic growth. Until now, all econometric analyses for the relationship between economic complexity and growth were done by implementing methods in which each country is valued equally. However, the countries are heterogeneous – they exhibit individual characteristics that directly encourage the complexity, and are in tight relation with growth. Therefore, in this paper the analysis is faced towards one region - Southeastern and Central Europe, and, in the spirit of the endogenous theory, a model is created which adequately captures the long run, as well as the short run relationship between the two variables. The results show that the economic complexity is a statistically significant explanatory variable of growth on the long run, and thus, it creates enormous economic implications. Contrarily, on the short run the productive knowledge has no effect on the income changes in Southeastern and Central Europe. All of this implies that the economic complexity reveals a structure which promotes development of long run strategies in the countries for inventing products. These strategies serve for the purpose of accumulating new capabilities that will help in creating and maintaining long term prosperity and economic growth.
Economic and Geographic Access to Food Retailers and Emergency Food Pantries

This study describes the environment in which low-income households acquire and purchase food by examining the local population characteristics of areas with and without emergency food pantries and by examining the locations of food pantries in relation to the retail food environment. We found that emergency pantries are located in areas (census tracts) in which individuals have low socioeconomic status and where there is high demand for services that pantries offer. About 25 percent of high-poverty areas without a retail food store have at least one pantry compared with 15 percent in all areas. Among high-poverty areas without supermarkets or superstores, 41 percent have at least one pantry. The study also finds that areas with one or more retail stores are more likely to have one or more pantries. Among retail store types, the relationship is strongest for convenience stores. The percentage of areas with at least one pantry increases from 22 percent in areas with no convenience stores to 44 percent in areas with more than one convenience store—a 22 percentage point increase. For supermarkets and superstores, this increase is about 12 percentage points—from 28 percent in areas with no supermarkets or superstores to 40 percent in areas with more than one store. Among areas with no stores, however, the percentage with at least one pantry is substantially higher in higher-poverty areas. Thus, while pantries and food retailers are located in similar areas, a sizable percentage of high-poverty areas with no stores have at least one pantry.
Sinusoidal current control strategy for 3-phase shunt active filter in grid-tied PV system

This paper describes about mitigation of power quality issues using Shunt active filter in a Grid connected hybrid energy system consisting of PV-Battery. The Shunt active filter control is based on Sinusoidal Current Control Strategy. Shunt Active Power Filters (ShAPF) is implemented in the hybrid systems to mitigate the harmonic current component as well as to recompense the imaginary or reactive power owing to their exact and reckless operation. Sinusoidal current based controller used in a ShAPF has been focused over here. Sinusoidal current control strategy is utilized to extricate sinusoidal current commencing from the source. The sinusoidal Currents in addition with a stout synchronizing circuit (Phase Locked Loop or PLL circuit), custom a brief controller meant for ShAPF which is precise by a sinusoidal current control based controller in order to perform like a harmonic isolator amid supply and load. Action of the ShAPF under passive load conditions using non-linear load, the performance of the sinusoidal current control technique is evaluated using MATLAB R2016a. MATLAB simulation results validate the efficiency of the power filter system to mitigate harmonic, it also offered to validate the control strategy. Total Harmonic Distortion (THD) of voltage as well as of current determines the practical feasibility of controller designed for ShAPF to deliver a harmonic separation of passive loads.
The MRX complex regulates Exo1 resection activity by altering DNA end structure

Homologous recombination is triggered by nucleolytic degradation (resection) of DNA double‐strand breaks (DSBs). DSB resection requires the Mre11‐Rad50‐Xrs2 (MRX) complex, which promotes the activity of Exo1 nuclease through a poorly understood mechanism. Here, we describe the Mre11‐R10T mutant variant that accelerates DSB resection compared to wild‐type Mre11 by potentiating Exo1‐mediated processing. This increased Exo1 resection activity leads to a decreased association of the Ku complex to DSBs and an enhanced DSB resection in G1, indicating that Exo1 has a direct function in preventing Ku association with DSBs. Molecular dynamics simulations show that rotation of the Mre11 capping domains is able to induce unwinding of double‐strand DNA (dsDNA). The R10T substitution causes altered orientation of the Mre11 capping domain that leads to persistent melting of the dsDNA end. We propose that MRX creates a specific DNA end structure that promotes Exo1 resection activity by facilitating the persistence of this nuclease on the DSB ends, uncovering a novel MRX function in DSB resection.
ROBUST HOLISTIC ARCHITECTURE FOR SMART POWER SYSTEMS

This paper describes a new robust architecture, which is based on a holistic approach. It is an architecture of power systems in which all relevant components like electricity producer and storage (both regardless of the technology and size), grid (regardless of voltage level), customer and market, are merged into one single structure. It unifies all interactions within the power system itself and between it and market thus creating the possibility to harmonize them.
Internal model startup control for VSC-LCC based hybrid pseudo bipolar HVDC system

The startup procedures of VSC-LCC hybrid HVDC system involves the cooperative control between the converter stations, which put forward higher request for the closed-loop dynamic performance and robustness of the converter control system. The structure and parameters of the internal model controller are deduced based on the internal model of the converter station, then the cooperative startup control strategy is established. Finally, the electromagnetic transient simulation model is built. The results confirm that the internal model startup control designed could avoid the overvoltage and over current effectively during the startup procedures.
Remotely sensed canopy nitrogen correlates with nitrous oxide emissions in a lowland tropical rainforest.

Tropical forests exhibit significant heterogeneity in plant functional and chemical traits that may contribute to spatial patterns of key soil biogeochemical processes, such as carbon storage and greenhouse gas emissions. Although tropical forests are the largest ecosystem source of nitrous oxide (N2 O), drivers of spatial patterns within forests are poorly resolved. Here, we show that local variation in canopy foliar N, mapped by remote-sensing image spectroscopy, correlates with patterns of soil N2 O emission from a lowland tropical rainforest. We identified ten 0.25 ha plots (assemblages of 40-70 individual trees) in which average remotely-sensed canopy N fell above or below the regional mean. The plots were located on a single minimally-dissected terrace (<1 km2 ) where soil type, vegetation structure and climatic conditions were relatively constant. We measured N2 O fluxes monthly for 1 yr and found that high canopy N species assemblages had on average three-fold higher total mean N2 O fluxes than nearby lower canopy N areas. These differences are consistent with strong differences in litter stoichiometry, nitrification rates and soil nitrate concentrations. Canopy N status was also associated with microbial community characteristics: lower canopy N plots had two-fold greater soil fungal to bacterial ratios and a significantly lower abundance of ammonia-oxidizing archaea, although genes associated with denitrification (nirS, nirK, nosZ) showed no relationship with N2 O flux. Overall, landscape emissions from this ecosystem are at the lowest end of the spectrum reported for tropical forests, consist with multiple metrics indicating that these highly productive forests retain N tightly and have low plant-available losses. These data point to connections between canopy and soil processes that have largely been overlooked as a driver of denitrification. Defining relationships between remotely-sensed plant traits and soil processes offers the chance to map these processes at large scales, potentially increasing our ability to predict N2 O emissions in heterogeneous landscapes.
The Interplay between Glucose-Regulated Protein 78 (GRP78) and Steroids in the Reproductive System

The glucose-regulated protein 78 (GRP78) is a molecular chaperone that is responsible for protein folding, which belongs to the heat shock protein 70 kDa (HSPA/HSP70). Because of the conjunction of GRP78 transcription with endoplasmic reticulum stress, the chaperone plays an important role in the unfolded protein response (UPR), which is induced after the accumulation of misfolded proteins. In the last years, a significant body of research concentrated on interplay between GRP78 and sexual steroid hormones. Throughout this review, we describe the mechanisms by which GRP78 regulates steroidogenesis at multiple levels and how steroids modulate GRP78 expression in different mammalian reproductive organs. Finally, we discuss the cooperation between GRP78 and steroids for cell survival and proliferation in the context of reproduction and tumorigenesis. This new paradigm offers significant opportunities for future exploration.
What is Sexual Harassment? An Empirical Study of Perceptions of Ordinary People and Judges

In the movie “Horrible Bosses,” Jennifer Aniston plays a dentist, Dr. Julia Harris, who harasses her dental assistant, Dale, played by Charlie Day. She sprays water on his crotch, grabs his penis, accosts him while wearing nothing but a lab coat and underwear, and threatens to tell his fiancé that they had sexual relations unless he actually has sex with her. The other protagonists in the film mock Dale, saying her sexual advances are not bad, and that he should be thrilled his attractive boss shows interest in him. Movie-goers find these scenes humorous: they laugh at Dale’s high-pitched voice, his awkwardness when he is harassed, and his demands for a “rape-free environment. ” The movie’s humor relies on shared social knowledge that there are “legitimate” and “illegitimate” victims of workplace harassment. Public perceptions of sexual harassment map onto cultural scripts of who can be a legitimate victim. Put another way, if the roles were reversed – a male superior harassing a female subordinate – our interpretation of the events featured in the film would change. A male boss acting in that manner would be viewed as exerting his power to coerce his employee to have sex with him, and the employee’s friends would be encouraging her to find an attorney or a new job, at the very least. The scenes would no longer be humorous, and any attempt to make comedic humor of a male harassing a female would be deemed inappropriate, insensitive, and deplorable.
Searching related scientific articles using formal concept analysis

An important aspect of research is literature survey. Availability of large amount of literature across different domains trigger the need for optimized systems which provide relevant literature to researchers. We propose a search system based on keywords for text documents. This experimental approach provides a hierarchical structure to the document corpus. The documents are labelled with keywords using KEA (Keyword Extraction Algorithm) and are automatically organized in a lattice structure using Formal Concept Analysis (FCA). This groups the semantically related documents together. The hierarchical structure, based on keywords gives out only those documents which precisely contain them. This approach open doors for multi-domain research. The documents across multiple domains which are indexed by similar keywords are grouped together. A hierarchical relationship between keywords is obtained. To signify the effectiveness of the approach, we have carried out the experiment on Semeval-2010 Dataset. Results depict that the presented method is considerably successful in indexing of scientific papers.