Miracle-dz/UniFAR-FTUs huggingface dataset:
Generación de modelos matemáticos correlacionales entre afinidad y descriptores topológicos moleculares de antagonistas de glicina en receptores de glutamato

Introduction. Mathematical models that correlate chemical structure with biological activity have been useful in the design of new drugs and can be used to predict biological behavior of new, chemically related molecules. Objectives. A mathematical model was generated to correlate the substrate affinities with variations in the molecular topology of glycine antagonists in NMDA sub-class glutamate receptor and, subsequently, to propose new molecules with antagonist activity. Materials and methods. By use of molecular connectivity indexes, the electronic structure and atomic bonding patterns of 45 glycine antagonists were coded. Correlation between connectivity indexes and antagonist affinity was determined by regression analysis. Results. The connectivity index that best described affinity behavior was 4Xvpc, which indicates the relative importance of heteroatoms, the vicinity of aromatic ring substitutes, and valency gradient. The equations generated predicted new antagonist affinities, and the model was able to suggest structural requirements for designating compounds with increased affinity. Twelve new molecules were proposed, from which three appeared promising-based of the affinities previously calculated by means of the new equations. Energetic interaction analysis was developed as a control for the mathematical methodology. Conclusion. Glycine antagonists' structure were analyzed mathematically by means of connectivity indexes. The equations modeled receptor behavior and contributed useful information for new antagonist design.
Seroepidemiología de la toxoplasmosis en una comunidad marginal del Municipio Maracaibo, Estado Zulia, Venezuela.

The goal of this study was to determine the prevalence of anti-Toxoplasma gondii antibodies in a marginal community of the Municipality of Maracaibo, Zulia State, Venezuela and if there was a relationship between risk factors and infection. An epidemiological survey of personal data, living sanitary conditions and contact with cats was performed. A collection of 254 blood samples from male and female individuals, with ages ranging from 8 months to 76 years, was studied. Anti-Toxoplasma gondii reaction was determined by indirect hemaglutination using a commercial kit. A positive reaction at a dilution 1:64 was considered positive. Statistical analysis was performed using the Chi-squared test. The prevalence of infection was found to be 36.6%. It was observed that 21.5 % of the seropositive presented titers not considered significant ( 1:64), 51.6 % had intermediate titers (1:128 to 1:512), 24.8 % high titers (1:1024 to 1:4096) and 2.1 % very high titers ( 1:8192). The highest percentage of positivity (50%) was observed in the group 46 years of age. No statistically significant association was observed between prevalence and risk factors (living together with cats and poor sanitary conditions of living) or infection when the chisquare test was used. Toxoplasma gondii infection was often found in the community of Puerto Caballo and probably cats and poor living conditions have a role in the transmission of infection. Recibido: 28-09-2000. Aceptado: 16-05-2001.
The effect of orientation tour with angiography procedure on anxiety and satisfaction of patients undergoing coronary angiography

Introduction: Recently, coronary angiography has become the largest interventional diagnostic test in cardiac patients worldwide having large effects on anxiety and satisfaction of patients in treatment and care. This study aimed to study the effect of orientation tour on anxiety and satisfaction of patient candidates for coronary angiography procedures. Method: In this randomized control trial study, 148 patients were recruited by random allocation. Patients were divided into two groups with block randomization. Patients in Intervention group, in addition to routine training, orientation tour in the angiography unit was taken too. Anxiety was measured in all patients during admission, before surgery and discharge time; the satisfaction was measured in discharge time too. Collection instruments were according to demographic data, Spielberger state trait anxiety inventory and the Visual Analogue Scale. The Information was obtained by t-test, chi-square and repeated measured were analyzed by SPSS. Results: After the orientation tour, anxiety scores significantly in the intervention group (39.5) compared with the control group (48.26) which decreased (P<0.001). Anxiety scores at discharge decreased in the intervention group (33.24) compared with the control group (41.22) which was significant (P<0.001). The mean patient satisfaction score at discharge in the intervention group (9.77) compared to control group (6.11) was statistically significance (P<0.001). Conclusion: Orientation tour in patient candidates to angiography, reduces anxiety and increases satisfaction, therefore, use of this educational approach in patients undergoing coronary angiography is recommended.
Editorial Peer Review: Its Strengths and Weaknesses.

Health sciences librarians study and teach the principles of evidence-based medicine (EBM), search evidence-based health care (EBHC) resources, and strive to practice evidence-based librarianship (EBL) [1]. In this work, Weller extends “EB” awareness to evidence-based scientific publishing. By providing a systematic review of empirical studies on the editorial peer review process from 1945 to 1997, the author assembles the available evidence on the value and validity of that process and its effect on the quality of the published literature. The author presents the strengths and weaknesses of peer review, analyzes the benefits and shortcomings, makes recommendations for further research, and provides information for improving future studies. With perhaps 6,000 to 7,000 scientific articles written every day [2] and with the review process for just one journal estimated to cost about $1 million a year [3], questioning the worth of this process is appropriate.
El rol de la jerarquía remática en la comprensión de oraciones con distinta configuración sintáctico-semántica

El procesamiento del lenguaje involucra fenómenos de índole enteramente distinta que, sin embargo, se integran necesariamente para constituir una unidad de sentido. Propiedades fonológicas, sintácticas, semánticas y pragmáticas se acoplan sistemáticamente para dar lugar a una oración, la unidad de comunicación humana que es el punto de partida y centro de la gramática. Es precisamente el rol de la gramática dar lugar a esa integración que se centra alrededor de dos funciones. Caracterizadas muy sucintamente, una es estática y consiste en almacenar símbolos y patrones o esquemas. La otra es dinámica y remite a integrar esa información en una secuencia quizás enteramente inédita y, además, adecuada a un contexto posiblemente único. El procesador de lenguaje se encuentra así frente a la tarea de construir una representación ―quizás totalmente novedosa― recuperando categorías y esquemas ya almacenados (efecto ‘pinza’; París en prensa). La gramática es de una ayuda esencial. Por un lado, el diseño de las unidades y esquemas almacenados es tal que está abierto a combinaciones nóveles. Por otro lado, la misma gramática incorpora nociones pragmáticas específicamente diseñadas para adecuar ciertos aspectos de las representaciones a las demandas de un contexto individual. En este trabajo analizamos, precisamente, la interacción entre un fenómeno altamente estructural y otro pragmático específicamente diseñado para la adecuación al contexto. Esa interacción está mediada por una misma marca lingüística: el orden de palabras. El fenómeno estructural en cuestión es el enlace sintaxis-semántica. Durante las últimas décadas, se le ha prestado especial atención al estudio de la interfaz sintaxis-semántica ya que es a través del proceso de enlace entre
DOĞUM EYLEMİNDE GEBELERİN ANKSİYETE DÜZEYLERİNİN İNCELENMESİ

Investigation of Anxiety Levels of Pregnant Women in Labor Aim: This study was conducted with the aim of determining the factors affecting their anxiety levels of the pregnants in the act of birth. Method: This study which has sectional quality was carried on 130 pregnant women selected from those who apply to the hospital for labor between the dates 25th June 2011 and 15th August 2011. The data were collected by using Situational Anxiety Scale of Spielberg and a survey in the evaluation of the data, percentage, variance analysis and t-test were used. Findings: In the study, it was found out that 38.5% of the pregnants was in 20-24 age group, that 63.1% were primary school graduate and that 58.5% of the pregnants lived in city- center and that 48.5% of the pregnants became the first time pregnant. In addition, total score average of Situational Anxiety Scale of the pregnants was 40.88±6.25. there was a significant relationship between living place, educational situation and the number of pregnancies of the pregnants (p <0.05). In conclusion: It can be said that score averages of the pregnants obtained from Situational Anxiety Scale became moderate level, but those of living in villages and having low-educational level became high level.
How and why consciousness arises: Some considerations from physics and physiology

We offer a scientific approach to the philosophical ‘hard problem’ of consciousness, as formulated by David Chalmers in this journal. Our treatment is based upon two recent insights concerning (1) the endogenous nature of consciousness and (2) the minimal thermodynamic conditions for being alive. We suggest that a combination of these insights specifies sufficient conditions for attributing feeling to being.
Protein kinase signaling : Intracellular messengers as potential targets for intervention in renal disease

Het aantal patienten met nierfalen is in de afgelopen decennia gestegen. Om nieuwe therapieen mogelijk te maken is het nodig om schadelijke mechanismen in de nier te ontdekken. Promovendus Martin de Borst onderzocht welke rol proteine kinases spelen, de boodschappermoleculen binnen in cellen. Hij gebruikte een nieuwe technologie. Deze maakt het mogelijk de activiteit van duizenden proteine kinases tegelijkertijd te bestuderen. Eerder werd de technologie alleen toegepast in gekweekte cellen en bloedcellen. De Borst toont aan dat deze nieuwe techniek ook bruikbaar is om beschadigde weefsels, in dit geval nierweef­sel, te onderzoeken.
Patientenregister als epidemiologische Werkzeuge

Zusammenfassung Mit der Zunahme der Inzidenz chronisch entzündlicher Darmerkrankungen (CED), insbesondere des Morbus Crohn im Kindes- und Jugendalter, richtete sich die Aufmerksamkeit der Wissenschaft auf die Merkmale der pädiatrischen CED. V. a. längere Krankheitszeiten, Schmerzen und Untergewicht behindern die körperliche, seelische und schulische Entwick-lung. Kinder- und Jugendärzte sollten mit den Besonderheiten des Krankheitsverlaufs und den Komplikationen der CED in der Pädiatrie vertraut sein, um den Betroffenen zu helfen, ihr Entwicklungspotenzial voll auszuschöpfen. In westlichen Ländern entstanden Patientenregister, die aufgrund institutioneller Bindungen meist nur einen Teil der Population erfassen. Mit dem sächsischen Kinder-CED-Register wurde 2000 ein flächendeckendes Dokumentationssystem für den Verlauf der CED im Kindesalter etabliert. Auf dieser Erfahrung aufbauend wurde 2004 von der Gesellschaft für pädiatrische Gastroenterologie und Ernährung (GPGE) das deutschsprachige Register CEDATA ins Leben gerufen, das mittlerweile die weltweit größte Zahl von Kindern und Jugendlichen mit CED in einer Kohorte vereint.
A Deviation Revealing Approach for Data Cleaning

: Information superiority is significant to organizations with the use of data mining; Anomalous data values detection is a most important step in many data related applications. Anomalous data make the performance of data analysis difficult. The presence of anomalous data value can also pose serious problems for researchers. In fact, in appropriate handling of the Anomalous data values in the analysis may introduce bias and can result in misleading conclusions being drawn from a research study and can also limit the generalize ability of the research findings. There are numerous techniques for Anomalous data detection, while using Inliers and Outlier techniques and their different measures in data mining. This article introduces anomalous data detection algorithm that should be used in data mining systems. Basic approaches currently used for solving this Anomalous data values finding, problem are considered, and their results are discussed using table.
La combinación de inhibidores de la enzima convertidora y bloqueantes cálcicos es el tratamiento de elección para reducir el riesgo cardiovascular en pacientes hipertensos

El 5 de mayo de 2008 fue tapa de todos los diarios del mundo que en el país de Myanmar hubo 10.000 muertos como consecuencia de un ciclón. Dos días antes, la revista The Lancet (1) publicó un artículo de la OMS en el que se planteaba que la hipertensión arterial y sus complicaciones son la principal causa de muerte en el mundo, con 20.821 víctimas por día. Llamativamente, eso no fue noticia.
Differential vascular α1‐adrenoceptor antagonism by tamsulosin and terazosin

Aims In patients with lower urinary tract symptoms suggestive of benign prostatic obstruction the α1-adrenoceptor antagonist terazosin lowers blood pressure whereas only very small if any alterations were reported with the α1-adrenoceptor antagonist tamsulosin. Therefore, we have compared the vascular α1-adrenoceptor antagonism of tamsulosin and terazosin directly. Methods Ten healthy subjects were investigated in a randomized, single-blind, three-way cross-over design and received a single dose of 0.4 mg tamsulosin, 5 mg terazosin or placebo on 3 study days at least 1 week apart. Before and 1, 3, 5, 7, 10 and 23.5 h after drug intake, alterations of diastolic blood pressure and other haemodynamic parameters in response to a graded infusion of the α1-adrenoceptor agonist phenylephrine were determined non-invasively. Results At most time points tamsulosin inhibited phenylephrine-induced diastolic blood pressure elevations significantly less than terazosin (5 h time point: median difference in inhibition 35%, 95% CI: 18.7–50.3%). On the other hand, phenylephrine-induced changes of cardiac output, heart rate and stroke volume were similar during both active treatments. Conclusions In doses equi-effective for treatment of lower urinary tract symptoms tamsulosin causes less inhibition of vasoconstriction than terazosin.
Parasitic disease in the pediatric intensive care unit - A review of severe manifestations of pediatric parasitic disease

Abstract Parasitic diseases, previously thought to be the domain of developing nations only, are being increasingly recognized as a significant source of morbidity/mortality in developed and developing nations alike. While many parasites cause long-term low-level disease, some parasitic diseases can have severe manifestations necessitating intensive care unit admission. In this review, we focus on severe malaria (including cerebral malaria), neurocysticercosis, Strongyloides hyperinfection syndrome, American trypanosomiasis (Chagas disease), baylisascariasis and amoebic meningoencephalitis.
Implementation of Plastic Fusing Method to Upcycle Products of Plastic Waste

Plastic waste is one of the most numerous in number, approximately 10 % of the total waste in the world. Plastic packaging, grocery bags, and home furnishings are the types that often found. There have been many efforts to reduce the amount of waste and the impact it causes, one of them is the up-cycling method. Up-cycling is the utilization method of waste products that have more value or new. By using this method, in addition to being able to reduce the plastic waste amount while creating new products with new value and functionality, namely small wallets, shopping bags, backpacks, gadgets sleeve etc. One method of upcycling plastic is plastic fusing methods that uses heat and plastic waste to create new materials with thickness and strength. The current utilization of plastic waste has been undertaken by communities to produce a product, namely craftsman group named Kunarti but less variety of processing methods, limited to knitting method only. Based on the phenomenon, this research was conducted to find out how the application of the plastic fusing method so that it can be easily done, and into alternative methods of upcycling which is can be applied by the craftsmen community in Bandung.
Low frequency noise in SIMOX MOSFETs

An extensive study has been made of low-frequency noise in MOSFETs built in a variety of SIMOX (separation by implanted oxygen) processes. Most of the devices studied showed very high noise levels dominated by generation-recombination noise. Among the devices measured were NMOS and PMOS FETs with superficial Si layers ranging in thickness from 0.3 mu m (no epi layer) to 2.5 mu m (with epi). SIMOX implant doses ranged from 1.4*10/sup 18/ cm/sup -2/ to 1.8*10/sup 18/ cm/sup -2/. Anneal times varied from 3 to 16 hours, and anneal temperatures varied from 1150 degrees C to 1275 degrees C. The shape and level of the measured noise spectra varied strongly as a function of back or front surface potential. Classic 1/f noise was not observed and was probably masked by other processes. Over the measured frequency range (10 Hz to 10 kHz) the noise was dominated by fluctuations in the channel carrier concentration due to trapping. From the shape of the noise spectra and their strong dependence on surface potential, it is concluded that the traps are not located in either the top or bottom oxide layers but in the bulk. A few distinct trap levels, each with an associated time constant, interact most strongly with channel carriers when the Fermi level aligns with the trap level, which accounts for the strong dependence on surface potential. It appears likely that these traps are associated with the dislocations typically generated in the SIMOX process. <<ETX>>
Prevalence and predictors of carotid artery atherosclerosis and its association with coronary artery disease in north Indian population

Background: The reported prevalence of concomitant coronary and carotid atherosclerotic disease has varied among studies due to differences in study populations and methodologies used. Objectives: The purpose of the study was to know the prevalence of carotid atherosclerotic disease and to evaluate the relationship between coronary and carotid atherosclerotic disease. Materials and Methods: We performed a prospective study from December 2010 to November 2012 to determine the association of carotid artery stenosis (CAS) with documented coronary artery disease on Angiography in Kashmiri population. Continuous variables were expressed as mean ± SD. Two-sided unpaired "t"- test was performed for continuous variables and x 2 test for discrete variables. Multivariate stepwise logistic regression analysis was performed to detect independent predictors of CAS using factors that had significant relation in univariate analysis. A value of P ≤ 0.05 was considered statistically significant. Results: The study included 100 patients among whom 19.0% had significant carotid atherosclerotic stenosis (stenosis > 50%). The severity of carotid atherosclerotic stenosis and the carotid artery disease were significantly correlated (P = 0.001). The percentage of patients with three vessel involvements (42.1%) and significant carotid stenosis were more as compared with two vessels (31.6%) and one vessel involvement (21.1%). Independent predictors of significant CAS were the presence of left main descending carotid artery disease (31.3%), triple vessel carotid artery disease (17.8%), increasing age, a history of stroke or myocardial infarction (21.05%), smoking status (78.9%), diabetes mellitus (78.94%), and hypertension (78.94%). We did not find any significant correlation between carotid atherosclerotic stenosis and gender or degree of dyslipidemia. Conclusions: The degree of carotid atherosclerotic disease is related to the extent of coronary artery disease and important risk factors.
Veterans Education: Coming Home to the Community College Classroom.

The purpose of this study was to identify the needs of veterans who are community college students and to examine community college programs and services essential to meeting their needs. A qualitative case study design using interviews, observations, field notes, document reviews, a focus group, and a preinterview demographic questionnaire provides a holistic account of the community college experience for veterans of the Iraq and Afghanistan Wars. This research study gives a voice to veterans who are community college students, and provides community colleges with insights that may enable them to improve their services for this population. Five major themes relating to the veterans’ perspectives of their needs at the case institution emerged from the data: (a) credit streamlining; (b) streamlining of programs and services; (c) faculty, advisor, and counselor training; (d) difficulties encountered by veterans, and (e) factors that constitute a veteran friendly campus. These five themes are linked and presented in an integrated way in order to holistically address the study’s three research questions. What do veterans perceive their needs to be at the community college? What programs and services are currently in place at the community college to address the needs of veterans? What recommendations can be made for improving the veterans’ community college experience? This study adds to the body of knowledge and potentially contributes to a future blueprint for the successful education of veterans who are community college students.
HUBUNGAN INFEKSI KECACINGAN DENGAN STATUS HEMOGLOBIN PADA ANAK SEKOLAH DASAR DIWILAYAH PESISIR KOTA MAKASSAR PROPINSI SULAWESI SELATAN TAHUN 2013

Worm infection are major public health problem and cause of under nutrition and cognitive disorder, with school children usually suffer the heaviest disease burden. The main prupose of this study was to know associated of helminthiasis infection with hemoglobin status in primary child school. This study needed prevalence rate of anemia and worm infection, this study needed of the type of worm infected most. Design of this study was cross sectional study. The sample was selected using purposive sampling. The setting of this study was in coastal area of Makassar, South Sulawesi. A total of sample in this study are 100 sample. This study showed were prevalence of anemia was 38%, prevalence of worm infection was 57% and the type of worm was infected most was Ascaris lumbricoides was 34%. In this study, there is not associated between worm infection (p=0,57) and severity of Ascaris lumbricoides(p=0,52) with hemoglobin status. The counsultation, the data showed that the prevalention of worm infection was high in primary child school and there was not associated between worm infection and hemoglobin status. The recommended of this study, warm infection have a high prevalence in coastal area of Makassar. To remember that the impact of worm infection, the primary child school in coastal area of Makassar, South Sulawesi needed prevention and treatement of helminth infection. The weakness of this study was not talking into a count wheather women correspondent menstruating.
Survivorship in Hodgkin Lymphoma

Hodgkin lymphoma (HL), formerly called Hodgkin’s disease, is a malignancy of mature Bcell lineage (germinal or post-germinal center), with over 8,000 new cases diagnosed annually in the United States. [1] HL has historically been characterized by many histologic subtypes with the finding of Reed-Sternberg cells unify the diagnosis. HL is well known to have a bimodal distribution of incidence, occurring most frequently in two distinct age groups: young adults (age 15-35) and those ages greater than 55 years old. For the purpose of this chapter, we will focus on the young adults treated for and cured of HL with radiation therapy (RT), chemotherapy, or combined modality therapy (CMT).