Miracle-dz/UniFAR-FTUs huggingface dataset:
Changing Trends in Nutritional Behavior among University Students in Greece, between 2006 and 2016

The objective of the present survey was to study the dietary behavior of university students residing away from the family home. In this context, we (a) compared their dietary habits in two time periods, namely 2006 and 2016; and (b) explored the possible impact of gender on the behavioral changes in nutritional choices. A total of four hundred and five university students (2006, n = 242; 2016, n = 163) participated in the study. Dietary assessment was carried out using a qualitative Food Frequency Questionnaire, while data about demographic and lifestyle factors were also collected. Students’ dietary habits have been modified in a generally desirable direction, as reflected, e.g., in the elevated consumption of several plant-based foods. Gender was also significantly associated with Body Mass Index (BMI) and changes in dietary attitudes. Possible reasons for the transition towards healthier and more balanced dietary habits could involve the budgetary constraints facing Greece in the last decade, as well as increasing nutritional awareness and other socio-cultural factors characterizing this target group. A deeper understanding of these relations would be crucial to foster nutritional education and further enhance the effectiveness of health promotion campaigns.
Mensch-Maschine-Systeme - Das Wesen der Technik im arbeitswissenschaftlichen Milieu

Die vorliegende Untersuchung will auf zweierlei Weise mit dem Wissen und den Praktiken rund um den Begriff der "Anthropotechnik" umgehen. Im ersten Schritt wird versucht, konzis auf historisch-diskursive Weise Parameter des Begriffes einer Anthropotechnik und seiner Entstehung um 1960 im ergonomischen Kontext aufzuzeigen. Im zweiten Schritt wird von diesem Terminus ausgehend die Frage nach Mensch und Maschine im arbeitswissenschaftlichem Kontext gestellt. "Anthropotechnik" ist im arbeitswissenschaftlichen Feld ein wichtiger und gelaufiger Terminus, seine lange Geschichte scheint jedoch meist unbekannt zu sein. Als prothetischer Begriff verweist "Anthropotechnik" auf eine eindrucksvolle Pluralitat verschiedener Wissenszusammenhange, die sich durch eine Begriffsgenealogie aufzeigen und auf verschiedene diskursive Netzwerke hin genauer untersuchen lassen. Die vorliegende Ausfuhrung will in diesem Sinne versuchen zu zeigen, wie sich in der Position gleichwertiger Mensch-Maschine-Aktanten eine Moglichkeit der Konstitution von Systemen als menschlichmaschinelle Konstrukte aufdeckt, und wie man sich dem essentiellen Problem der Positionierung des Menschen in diesem technischen Milieu annahert. Die Frage nach einem sozialen Status der Maschine im System stellt sich auf diese Weise mit der Anthropotechnik in all ihrer systematischen und diskursiven Veranderung verscharft.
Predicting Ash Deposit Tendency in Thermal Utilization of Biomass

In thermochemical utilization of biomass, ash produced during the process is a major problem that can result in decreased performance and increased in difficulty during operation. Preliminary assessment of potential ash related troubles prior to the use of a specific biomass is valuable, even if it is only a general guideline. In this work, tendency of ash slagging, fouling and agglomeration in thermal processing of biomass was evaluated. Reference peered reviewed data including mineral content and fusion temperature of selected biomass ash were used to calculate multiple indicators (base to acid ratio, slagging index, fouling index, agglomeration index, slag viscosity index, and ternary diagram of main biomass ash composition) adopted from coal research. Major ash forming elements (Fe, Ca, Mg, K, Na, Al, Si) were found to be of relevance to ash melting and deposit behavior. For conventional biomass available locally, woody biomass (wood and wood sawdust) may be combusted without slagging or fouling problem, while non-woody biomasses (bark, husk, straw) are highly probable to experience some of these problems. The ash fusibility predictive models for woody and non-woody biomass were found to be effective. Mitigation can then be designed possibly via fuel blending to avoid or minimize the impact of biomass ash related trouble.
The Relationship Between Structural and Functional Brain Changes and Altered Emotion and Cognition in Chronic Low Back Pain Brain Changes: A Systematic Review of MRI and fMRI Studies

Objectives:Chronic low back pain (CLBP) is a major health issue, yet its underlying mechanisms remain unknown. Studies have demonstrated the importance of emotion and cognition in chronic pain; however, the relevant brain physiology in magnetic resonance imaging (MRI) studies are unclear in CLBP populations. Therefore, this review aimed to identify MRI brain changes and examine their potential relationship with emotional and cognitive processes in CLBP. Methods:A systematic search was conducted in 5 databases. Studies that recruited adult, CLBP populations, and used brain MRI protocols were included. Results:In total, 55 studies met the inclusion criteria. Of the structural MRI studies, 10 of 15 studies found decreased gray matter and 7 of 8 studies found white matter changes in CLBP groups compared with controls. Fourteen resting-state functional MRI studies all reported differences between CLBP and control groups in the default mode network. Interestingly, only 3 of 10 functional MRI studies observed significant differences during noxious stimulation between CLBP and control groups, whereas 13 of 16 studies observed significant brain activation differences in CLBP groups during various external tasks. Finally, there were 3 studies that observed a degree of recovery in functional connectivity following intervention. Discussion:The brain changes in CLBP groups were mainly observed in areas and networks important in emotion and cognition, rather than those typically associated with nociception. This supports the understanding that emotional and cognitive processes may be the core contributor to the CLBP experience; however, future studies need to explore these processes further.
Mechanisms of action of Rab proteins, key regulators of intracellular vesicular transport

Abstract Our understanding of the manner in which Rab proteins regulate intracellular vesicular transport has progressed remarkably in the last one or two decades by application of a wide spectrum of biochemical, biophysical and cell biological methods, augmented by the methods of chemical biology. Important additional insights have arisen from examination of the manner in which certain bacteria can manipulate vesicular transport mechanisms. The progress in these areas is summarized here.
Information-Theoretic Representation Learning for Positive-Unlabeled Classification

Recent advances in weakly supervised classification allow us to train a classifier from only positive and unlabeled (PU) data. However, existing PU classification methods typically require an accurate estimate of the class-prior probability, a critical bottleneck particularly for high-dimensional data. This problem has been commonly addressed by applying principal component analysis in advance, but such unsupervised dimension reduction can collapse the underlying class structure. In this letter, we propose a novel representation learning method from PU data based on the information-maximization principle. Our method does not require class-prior estimation and thus can be used as a preprocessing method for PU classification. Through experiments, we demonstrate that our method, combined with deep neural networks, highly improves the accuracy of PU class-prior estimation, leading to state-of-the-art PU classification performance.
Lowering dynamic power in stream-based harris corner detection architecture

Stream-based image processing architectures are extremely attractive as they can achieve high throughput and do not require external memories for storing input video frames. However, a major challenge in designing stream-based architectures lies in lowering the dynamic power consumption since all the processing elements are typically in continuous operation to keep up with the rate of incoming pixel streams. In this work, we show that the dynamic power of the stream-based Harris corner detector (HCD) can be reduced by inhibiting redundant signal activity in the complex calculations of the corner scores. Specifically, we perform simple approximations to detect non-likely corners at the early stages of the pipeline for putting the subsequent pipeline stages into a dormant state. Synthesis results on the Altera Cyclone V FPGA show that the proposed strategy leads to an average dynamic power reduction of over 10% compared to the conventional implementation with similar performance and negligible increase in resources. In addition, we performed repeatability tests to show that the proposed stream-based HCD architecture achieves comparable accuracy with the conventional implementation.
Design of gilbert-double balanced mixer for WBAN

Paper presents design of an active RF CMOS Double balanced Gilbert mixer to be used in WBAN (Wireless Body Area Network). The present Mixer is designed for RF frequency of 2.4GHz, LO frequency of 2GHz and IF frequency of 400MHz with a supply voltage of 1.8V and achieved parameter 16.2dB, input intercept point (IIIP3) of 5.3 and 1 dB compression point of − 29.57dBm. This design is implemented using 180nm CMOS-VLSI technology, Cadence Virtuoso
The prevalence and factors associated with ever perpetrating intimate partner violence by men receiving substance use treatment in Brazil and England: A cross‐cultural comparison

INTRODUCTION AND AIMS Intimate partner violence (IPV) perpetration is common among men who use substances. Substance use is a contributing factor for IPV perpetration. This cross-sectional study determined lifetime prevalence and factors associated with ever perpetrating IPV by men receiving substance use treatment in Brazil (n = 281) and England (n = 223). DESIGN AND METHODS IPV, adverse childhood experiences, attitudes towards gender relations and roles, current health state, substance use, depressive symptoms and anger expression were assessed. Logistic regression determined factors associated with ever perpetrating any (emotional, physical and/or sexual) IPV. Multinomial logistic regression determined factors associated with ever perpetrating different types of IPV. RESULTS 74.6% (373/500) reported ever perpetrating IPV: 16.5% (82/498) emotional IPV only, 46.4% (231/498) physical IPV (with/without emotional IPV) and 11.6% (58/498) sexual IPV (with/without emotional and/or physical IPV). Higher anger expression, higher depressive symptoms, fighting physically with another man in the past year (Brazil only), experiencing a greater number of adverse childhood experiences and a higher hazardous drinking score (England only) predicted ever perpetrating IPV. Compared to never perpetrating any IPV, anger expression was associated with emotional and physical IPV perpetration; fighting physically with another man in the past year was associated with physical IPV perpetration and experiencing a greater number of adverse childhood experiences and a higher hazardous drinking score were associated with both physical and sexual IPV perpetration. DISCUSSION AND CONCLUSIONS Integrated interventions that address IPV and substance use delivered in substance use treatment could improve outcomes for perpetrators and victims. [Gilchrist G, Radcliffe P, Noto AR, d'Oliveira AFPL. The prevalence and factors associated with ever perpetrating intimate partner violence by men receiving substance use treatment in Brazil and England: A cross-cultural comparison. Drug Alcohol Rev 2017;36:34-51].
Physicians' Views of Programs Incorporating Stages of Change to Reduce Smoking and Excessive Alcohol Consumption

Family medical practice is an ideal context for the early detection and delivery of programs to reduce tobacco and excessive alcohol use. Family doctors have a high contact rate with the general public and are readily accessible. L2 A study conducted among more than 13,000 patients served by 119 family physicians in Sydney reported that 35% of men and 29% of women were smokers 3 and 12 and 10%, respectively, were drinking alcohol at levels considered hazardous or harmful. 4 Indeed, a majority of these patients felt their doctor should be interested in their smoking and drinking. -~
Genomic data integration in chronic lymphocytic leukemia

B‐cell chronic lymphocytic leukemia (CLL) is a heterogeneous disease and the most common adult leukemia in western countries. IgVH mutational status distinguishes two major types of CLL, each associated with a different prognosis and survival. Sequencing identified NOTCH1 and SF3B1 as the two main recurrent mutations. We described a novel method to clarify how these mutations affect gene expression by finding small‐scale signatures that predict the IgVH, NOTCH1 and SF3B1 mutations. We subsequently defined the biological pathways and correlation networks involved in disease development, with the potential goal of identifying new drugable targets.
Ethanol produces corticotropin-releasing factor receptor-dependent enhancement of spontaneous glutamatergic transmission in the mouse central amygdala.

BACKGROUND Ethanol (EtOH) modulation of central amygdala (CeA) neurocircuitry plays a key role in the development of alcoholism via activation of the corticotropin-releasing factor (CRF) receptor (CRFR) system. Previous work has predominantly focused on EtOH × CRF interactions on the CeA GABA circuitry; however, our laboratory recently showed that CRF enhances CeA glutamatergic transmission. Therefore, this study sought to determine whether EtOH modulates CeA glutamate transmission via activation of CRF signaling. METHODS The effects of EtOH on spontaneous excitatory postsynaptic currents (sEPSCs) and basal resting membrane potentials were examined via standard electrophysiology methods in adult male C57BL/6J mice. Local ablation of CeA CRF neurons (CRF(CeAhDTR) ) was achieved by targeting the human diphtheria toxin receptor (hDTR) to CeA CRF neurons with an adeno-associated virus. Ablation was quantified post hoc with confocal microscopy. Genetic targeting of the diphtheria toxin active subunit to CRF neurons (CRF(DTA) mice) ablated CRF neurons throughout the central nervous system, as assessed by quantitative reverse transcriptase polymerase chain reaction quantification of CRF mRNA. RESULTS Acute bath application of EtOH significantly increased sEPSC frequency in a concentration-dependent manner in CeA neurons, and this effect was blocked by pretreatment of co-applied CRFR1 and CRFR2 antagonists. In experiments utilizing a CRF-tomato reporter mouse, EtOH did not significantly alter the basal membrane potential of CeA CRF neurons. The ability of EtOH to enhance CeA sEPSC frequency was not altered in CRF(CeAhDTR) mice despite a ~78% reduction in CeA CRF cell counts. The ability of EtOH to enhance CeA sEPSC frequency was also not altered in the CRF(DTA) mice despite a 3-fold reduction in CRF mRNA levels. CONCLUSIONS These findings demonstrate that EtOH enhances spontaneous glutamatergic transmission in the CeA via a CRFR-dependent mechanism. Surprisingly, our data suggest that this action may not require endogenous CRF.
Implementing Dynamic Assessments in Psychotherapy

In this article, we organize multimethod, multitimescale data around the interpersonal situation, a conceptual framework that can be used to integrate personality, psychopathology, and psychotherapy constructs in order to guide the assessment of clinical dynamics. We first describe the key variables of the interpersonal situation model and articulate methods for assessing those variables as they manifest (a) across different levels of personality, (b) across situations, and (c) within situations. We next use a case to demonstrate how to assess aspects of the interpersonal situation in a manner that enhances case conceptualization and facilitates the evaluation of clinical hypotheses. We also use this case to highlight challenges and decisions involved in implementing dynamic assessment in psychotherapy. We conclude by outlining areas in need of further exploration toward a more sophisticated approach to clinical practice that involves the routine assessment of dynamic processes.
Can gamma irradiation during radiotherapy influence the metal release process for biomedical CoCrMo and 316L alloys?

Abstract The extent of metal release from implant materials that are irradiated during radiotherapy may be influenced by irradiation‐formed radicals. The influence of gamma irradiation, with a total dose of relevance for radiotherapy (e.g., for cancer treatments) on the extent of metal release from biomedical stainless steel AISI 316L and a cobalt‐chromium alloy (CoCrMo) was investigated in physiological relevant solutions (phosphate buffered saline with and without 10 g/L bovine serum albumin) at pH 7.3. Directly after irradiation, the released amounts of metals were significantly higher for irradiated CoCrMo as compared to nonirradiated CoCrMo, resulting in an increased surface passivation (enhanced passive conditions) that hindered further release. A similar effect was observed for 316L showing lower nickel release after 1 h of initially irradiated samples as compared to nonirradiated samples. However, the effect of irradiation (total dose of 16.5 Gy) on metal release and surface oxide composition and thickness was generally small. Most metals were released initially (within seconds) upon immersion from CoCrMo but not from 316L. Albumin induced an increased amount of released metals from AISI 316L but not from CoCrMo. Albumin was not found to aggregate to any greater extent either upon gamma irradiation or in the presence of trace metal ions, as determined using different light scattering techniques. Further studies should elucidate the effect of repeated friction and fractionated low irradiation doses on the short‐ and long term metal release process of biomedical materials. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2673–2680, 2018.
Bioengineered keratocyte spheroids fabricated on chitosan coatings enhance tissue repair in a rabbit corneal stromal defect model

Cultivated cell spheroid transplantation is widely studied as a means of facilitating tissue regeneration. Chitosan biomaterial has been shown to promote keratocyte aggregation and multicellular spheroid formation. This study provides further evidence on application of bioengineered keratocyte spheroids for corneal stromal tissue engineering. In an allogeneic rabbit model of stromal destruction caused by bacterial keratitis, the corneas were intrastromally injected with isolated keratocyte suspensions or aggregated spheroid grafts at same cell number. Results of clinical observations and histological examinations on postoperative day 14 showed that when an antibiotic eye drop is only medication for inhibiting bacterial growth, permanent damage to stroma occurs, leading to disorganization of collagen lamellae and tissue structure as well as loss of corneal transparency and visual function. Intrastromal grafting of keratocytes provided additional benefits to overcome drawbacks of limited disease treatment performance associated with topically applied antibiotics. In particular, as compared to their cell suspension counterparts, bioengineered keratocyte spheroids had higher ability to preserve cellular phenotype, secrete collagen matrix, and enhance graft retention, suggesting excellent repair capability for managing stromal tissue defect and alleviating corneal haze/oedema. In summary, the findings emphasize the role of keratocyte configuration (i.e., two‐dimensional monolayer or three‐dimensional spheroid) in determining therapeutic potency of cellular allografts for stromal tissue reconstruction. Transplantation of keratocyte spheroids cultured on chitosan substrates may represent a promising strategy for corneal stromal repair.
Chlamydia trachomatis regulates growth and development in response to host cell fatty acid availability in the absence of lipid droplets

Chlamydia trachomatis (Ct) is a Gram‐negative obligate intracellular pathogen of humans that causes significant morbidity from sexually transmitted and ocular diseases globally. Ct acquires host fatty acids (FA) to meet the metabolic and growth requirements of the organism. Lipid droplets (LDs) are storehouses of FAs in host cells and have been proposed to be a source of FAs for the parasitophorous vacuole, termed inclusion, in which Ct replicates. Previously, cells devoid of LDs were shown to produce reduced infectious progeny at 24 hr postinfection (hpi). Here, although we also found reduced progeny at 24 hpi, there were significantly more progeny at 48 hpi in the absence of LDs compared to the control wild‐type (WT) cells. These findings were confirmed using transmission electron microscopy where cells without LDs were shown to have significantly more metabolically active reticulate bodies at 24 hpi and significantly more infectious but metabolically inert elementary bodies at 48 hpi than WT cells. Furthermore, by measuring basal oxygen consumption rates (OCR) using extracellular flux analysis, Ct infected cells without LDs had higher OCRs at 24 hpi than cells with LDs, confirming ongoing metabolic activity in the absence of LDs. Although the FA oleic acid is a major source of phospholipids for Ct and stimulates LD synthesis, treatment with oleic acid, but not other FAs, enhanced growth and led to an increase in basal OCR in both LD depleted and WT cells, indicating that FA transport to the inclusion is not affected by the loss of LDs. Our results show that Ct regulates inclusion metabolic activity and growth in response to host FA availability in the absence of LDs.
Aberrant Cerebellar Development in Mice Lacking Dual Oxidase Maturation Factors.

BACKGROUND Thyroid hormone (TH) plays a key role in the developing brain, including the cerebellum. TH deficiency induces organizational changes of the cerebellum, causing cerebellar ataxia. However, the mechanisms causing these abnormalities are poorly understood. Various animal models have been used to study the mechanism. Lacking dual oxidase (DUOX) and its maturation factor (DUOXA) are major inducers of congenital hypothyroidism. Thus, this study examined the organizational changes of the cerebellum using knockout mice of the Duoxa gene (Duoxa-/-). METHODS The morphological, behavioral, and electrophysiological changes were analyzed in wild type (Wt) and Duoxa-deficient (Duoxa-/-) mice from postnatal day (P) 10 to P30. To detect the changes in the expression levels of presynaptic proteins, Western blot analysis was performed. RESULTS The proliferation and migration of granule cells was delayed after P15 in Duoxa-/- mice. However, these changes disappeared by P25. Although the cerebellar structure of Duoxa-/- mice was not significantly different from that of Wt mice at P25, motor coordination was impaired. It was also found that the amplitude of paired-pulse facilitation at parallel fiber-Purkinje cell synapses decreased in Duoxa-/- mice, particularly at P15. There were no differences between expression levels of presynaptic proteins regulating neurotransmitter release at P25. CONCLUSIONS These results indicate that the anatomical catch-up growth of the cerebellum did not normalize its function because of the disturbance of neuronal circuits by the combined effect of hypothyroidism and functional disruption of the DUOX/DUOXA complex.