Miracle-dz/UniFAR-FTUs huggingface dataset:
Atherogenic Lipoproteins in Subclinical Hypothyroidism and Their Relationship with Hepatic Lipase Activity: Response to Replacement Treatment with Levothyroxine.

BACKGROUND Qualitative lipoprotein changes, such as an increase in fasting remnants, are reported in subclinical hypothyroidism (SCH). It was hypothesized that such changes are due to reduced hepatic lipase (HL) activity in SCH: HL is an enzyme regulated by thyroid hormones, and is involved in the degradation of triglyceride (TG)-rich remnants. This study aimed to quantify remnant-like lipoproteins (RLP), small dense LDL (sdLDL), and HL activity in women with SCH, and to assess these parameters after levothyroxine replacement therapy. METHODS This was an observational cross-sectional study with a subsequent longitudinal follow-up. Findings in women with thyrotropin levels >4.5 mIU/L (SH group) were compared with age- and body mass index (BMI)-matched euthyroid women (control group). In addition, a subgroup analysis was undertaken in SCH women who chose to receive levothyroxine treatment (0.9 μg/kg/day) for 6 months. RLP was quantified by measuring cholesterol (RLP-C) and triglycerides (RLP-TG) after immunoaffinity chromatography, and sdLDL by automated standardized methods; HL activity was measured in post-heparin plasma. RESULTS The SCH group included 37 women; 29 women were included in the control group. In addition, 22 women with SCH were included in the subgroup analysis (levothyroxine treatment). Significantly higher RLP values were observed in the SCH group than in the control group: RLP-C (median [range], mg/dL): 20.3 (5.8-66.8) versus 10.2 (2.7-36.3), p = 0.005; RLP-TG (mg/dL): 26.3 (3.2-123.3) versus 12.1 (2.5-61.6), p = 0.033. HL activity (mean ± standard deviation [SD], μmol free fatty acid/mL post-heparin plasma.h)-9.83 ± 4.25 versus 9.92 ± 5.20, p = 0.707-and sdLDL levels (mg/dL)-23.1 ± 10.7 versus 22.6 ± 8.4, p = 0.83-were similar. After levothyroxine, RLP-C decreased-21.5 (5.8-66.8) versus 17.2 (4.1-45.6), p = 0.023-and HL increased-9.75 ± 4.04 versus 11.86 ± 4.58, p = 0.012-in the subgroup of SCH women. No changes in sdLDL were observed. CONCLUSIONS Women with SCH have higher RLP levels than matched controls do, but their RLP-C levels decrease significantly following levothyroxine therapy. Furthermore, HL activity also increases after levothyroxine therapy and can be interpreted as a possible explanation for the decrease in RLP-C.
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The potential of pulse-based ultra-wideband (UWB) technology has been demonstrated for high-data-rate short-distance wireless personal area networks (e.g., wireless USB) [1-3]. With the allocation of the spectrum from 3.1 to 10.6GHz by the Federal Communications Commission (FCC), transmitter architectures based on using a mixer to upconvert a baseband pulse have emerged [1, 2]. In these systems, the carrier frequency is inherently in the middle of the transmission bandwidth. Hence, transmitter local oscillator leakage to the output may call for a reduction in transmit power to be FCC compliant.
Morphogenesis of bulboventricular malformations. II. Observations on malformed hearts.

The results are described of an investigation of specimens with bulboventricular malformations. The hearts examined had been previously classified as Fallot's tetralogy, double outlet right ventricle, or variousforms of transposition. After re-examination of the specimens, it was concluded that they represented a spectrum of malformations. While some were typical of the 'classical' description of known anomalies, others hadfeatures intermediate between two 'classical' anomalies. Yet others were considered to be examples ofrecently described anomalies such as 'posterior' transposition or double outlet left ventricle. We believe that the spectrum of anomalies can be directly interpreted in terms of variation in position of the embryological components of the bulboventricular loop. These components were described in detail in the first part of this study which was devoted to development in the normal heart, and are defined as the conoventricular flange, the conus septum, the trabecula septomarginalis, and the anterior and posterior segnients of the muscular ventricular septum. Our findings support the recent hypothesis that the spectrum can be explained in terms of conal rotation and conal absorption, but additionally suggest that reorientation of the anterior part of the muscular septum is a vitalpart of the process. The conclusions are discussed with regard to controversies concerning bulboventricular morphogenesis and nomenclature of supraventricular muscle bands of the right ventricle.
Parkinson's disease: 10 years of progress, 1997–2007

Many people with Parkinson's disease (PD) and their family members ask their physicians “What is happening in research on Parkinson's disease? Is there anything new? ” As the initial speaker at the symposium organized by the Parkinson's Disease Foundation in celebration of its 50th anniversary, I sought to address these questions, focusing on research published between the years 1997 and 2007. I cataloged the advances I considered most important in the field, recognizing my viewpoint is a subjective one and most likely differs from similar listings that others would put together. Space limitation allows me to discuss only a tiny fraction of the remarkable new findings that have been discovered during this 10‐year span. Nevertheless, I expect the readers of this summation of advances in the field to be as impressed as I am on the wealth, breadth, and excitement stirring in the field of PD research. Included in this overview are highlights in both laboratory science and clinical science of PD research. In the former category are advances in knowledge on the genetics of PD; potential etiologic and pathogenic causes, especially the better understanding of endogenous factors within dopaminergic neurons; pathologic changes including deposition of alpha‐synuclein aggregates; and the consequences of altered alpha‐synuclein on the degradation of proteins by both the ubiquitin‐proteasomal pathway and the lysosome. Clinical science has also been very active and impressively productive with important clinical advances. In this category are new information on the epidemiology of PD, including awareness of additional factors (besides smoking) that might slow the onset and worsening of PD, such as caffeine and urate; neuroimaging with positron emission tomography and single photon emission tomography; keener awareness of nonmotor features of PD and their impact on quality of life for the persons with PD and their family; recognition of behavioral complications of medications utilized to treat PD, such as impulse control problems; appreciation of the natural history of PD with the increasing impairments as the disease relentlessly worsens over time; the many controlled clinical trials attempting to slow the progression of the disease and to provide new symptomatic therapies; and surgical approaches to alleviate symptoms and progression, including cellular and gene therapy as well as deep brain stimulation. © 2010 Movement Disorder Society
Channel Equalizer Design Based on Wiener Filter and Least Mean Square Algorithms

This paper investigates the Wiener and least mean square (LMS) algorithms in the design of traversal tap delay line filters for the purpose of compensating the effect of the communication channel. The designed equalizers remove the distortion caused by the channel from the transmitted signal without requiring any specific model or state-space information. The first approach is based on the a recursive Wiener filtering procedure and is designed using the WienerHopf equation. On the other hand, the second approach uses the LMS algorithm and investigates the effect of different step sizes on the speed of the conversion and the accuracy of the overall algorithm. Simulation results are presented and both schemes are compared under different distortion levels and signal to noise ratio(SNR) values via impulse response, frequency response and ABER simulations.
iver Diseases in the Hemochromatosis and Iron Overload creening Study

AUL C. ADAMS,* LEAH PASSMORE, SUBRATA CHAKRABARTI,* DAVID M. REBOUSSIN, ONALD T. ACTON, JAMES C. BARTON, GORDON D. MCLAREN, JOHN H. ECKFELDT, ITZROY W. DAWKINS,** VICTOR R. GORDEUK,** EMILY L. HARRIS, ATHERINE LEIENDECKER–FOSTER, ELAINE GOSSMAN, and PHYLISS SHOLINSKY, FOR THE EMOCHROMATOSIS AND IRON OVERLOAD SCREENING STUDY RESEARCH INVESTIGATORS Department of Medicine and Pathology, London Health Sciences Center, London, Ontario, Canada; Department of Public Health Sciences, ake Forest University School of Medicine, Winston-Salem, North Carolina; Departments of Microbiology, Medicine, and Epidemiology and nternational Health, University of Alabama at Birmingham, Birmingham, Alabama; Southern Iron Disorders Center, Birmingham, Alabama; Veterans Affairs Long Beach Healthcare System, Long Beach, and Division of Hematology/Oncology, Department of Medicine, University of alifornia, Irvine, California; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota; *Department of Medicine, Howard University, Washington, District of Columbia; Kaiser Permanente Center for Health Research, Portland, regon; Department of Gastroenterology, Kaiser Permanente, Portland, Oregon; Epidemiology and Biometry Program, National Heart Lung nd Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland
Design of UWB printed monopole antenna with dual band notch filter

In this paper the design of UWB Printed monopole antenna with dual band frequency notch function is proposed. Dual band frequency notch is achieved by using only two ground slots, instead of four slots as usual, that by inserting four lumped capacitors into the model. The two ground slots are formed on the ground plate to achieve the first notch at frequency band (5.15–5.825 GHz) which is WLAN band for IEEE802.11, four lumped capacitors are inserted into these ground slots; the first two lumped capacitors are inserted to miniaturize the size of the slots which is decreased by 49% of their conventional size without lumped capacitors, the second two lumped capacitors are inserted to obtain the second notch at frequency band (3.3–3.9GHz) which is WiMax band. The effect of the positions of the slots with respect to the patch on the value of return loss is investigated, also simulation results of S11 for different states and radiation patterns at different frequencies are presented.
Performance evaluation of adaptive H8 space-time equalizers for wireless communication systems with asynchronous interference

Packet-switched multi-access communication systems may have difficulties on detecting a user signal due to a momentary interference, which is caused by packet transmissions of a co-channel interferer user. Asynchronous co-channel interference impacts directly the performance of the reception process, specially in the uplink (mobile to base station transmission). In this work, the Hinfin filter is configured as an adaptive space-time equalizer and its performance is compared to that of the RLS- based space-time equalizer, in the presence of asynchronous interference. Computational simulations are performed for single- input multiple-output (SIMO) channels with spatial diversity.
Quantitative analysis of peristalsis in the guinea‐pig small intestine using spatio‐temporal maps

1 Peristalsis was evoked in guinea‐pig small intestine by slow fluid infusion and recorded onto video and digitized. Spatio‐temporal maps of diameter and longitudinal movement were constructed and parameters of motion were calculated. 2 During the filling of the isolated segments of intestine, rhythmic local longitudinal movements were observed at several points along the preparation. These phasic longitudinal muscle contractions were associated with small but significant local increases in diameter and probably reflect a passive mechanical coupling by connective tissue in the gut wall. In addition, occasional synchronized longitudinal muscle contractions caused net shortening of the preparation and always preceded the onset of peristaltic emptying. 3 Peristaltic emptying was characterized by a contraction of the circular muscle which usually started at the oral end of the preparation, that propagated aborally, propelling the contents. However, in 19% of trials, the first circular muscle contraction occurred in the aboral half of the preparation. 4 The propagation of peristalsis consisted of separate sequential circular muscle contractions several centimetres long, particularly in the oral half of the preparation, giving a ‘step‐like’ appearance to the spatio‐temporal map. The gut was transiently distended aboral to the propagating circular muscle contraction due to the propulsion of contents. 5 At each point in the preparation, the longitudinal muscle remained contracted during the propulsive part of the circular muscle contraction. Only when the circular muscle contraction became lumen occlusive did lengthening of the longitudinal muscle take place. 6 Spatio‐temporal maps are a powerful tool to visualize and analyse the complexity of gastrointestinal motility patterns.
Coordinating Social Media Management Interfaces Across the Organization

To establish a holistic framework for approaching social media management that offers a way to approach new, amplified and emerging interfaces affecting organizations. We apply Porter's historic value chain model as a scaffold to approach a holistic understanding of social media management and organize highly cited concepts related to social media management from the fields of IT and Corporate Communication. We find that classifying current studies in relation to secondary and primary activities from an historic value chain scaffold enables researchers to define and classify interfaces that can inform our understanding of social media management in a holistic manner. From an activity perspective, both primary and secondary activities related to social media can be argued to have interfaces with social media platforms, participants and audiences. In addition, interfaces enabled by social media technology affordances can be classified as new, amplified or emergent. Using a historic approach to organizationa.
SUSTAINABLE DEVELOPMENT OF FUTURE FIRM REPUTATION

Purpose – The purpose of this paper is to explain whether sustainability development of firm reputation dimensions will enhance to perform and to reach firm reputation. Design/methodology/approach - The role of accounting research that is considered and supported accounting practice may help to provide accounting information related the investor decision making. This research is preliminary study and this research approaches based on explanatory with meta-analysis. In theory, the environment of accounting is both very complex and very challenging. The complex is because the product of accounting is information. The firm reputation dimensions seem important in terms of increasing the future firm reputation that could bring result of competition advantages. Finding – The principal finding of sustainable development of firm reputation adoption is to perform the expected firm growth. Original/value–The results of this study make contribution to quick response for investor to make investment decision on the outcomes of firm reputation should be the value to investor who wants the data accuracy and reliable accounting information. Keywords: sustainability development, sustainability development offirm reputation dimensions, accounting information.
Performance Evaluation of Distributed Mobility Management Protocols: Limitations and Solutions for Future Mobile Networks

Mobile Internet data traffic has experienced an exponential growth over the last few years due to the rise of demanding multimedia content and the increasing number of mobile devices. Seamless mobility support at the IP level is envisioned as a key architectural requirement in order to deal with the ever-increasing demand for data and to efficiently utilize a plethora of different wireless access networks. Current efforts from both industry and academia aim to evolve the mobility management protocols towards a more distributed operation to tackle shortcomings of fully centralized approaches. However, distributed solutions face several challenges that can result in lower performance which might affect real-time and multimedia applications. In this paper, we conduct an analytical and simulated evaluation of the main centralized and proposed Distributed Mobility Management (DMM) solutions. Our results show that, in some scenarios, when users move at high speed and/or when the mobile node is running long-lasting applications, the DMM approaches incur high signaling cost and long handover latency.
Security threats for Big Data

The world is advancing towards technological evolution day by day resulting in an exponential rise in Data. This massive volume of Data has introduced the idea of Big Data, which has captured the attention of business and IT scholars as a blessing and a source of immense opportunities for large organizations. Securing this huge amount of data has become a great concern in the field of information and communication technology. In this paper, we have conducted two studies to observe the security threats for big data: (a) first study was carried out on Enron email dataset (that contains about half a million of emails) to investigate the security challenges of big data in the field of email communication; and (b) second study was carried out on 35 undergraduate students to observe how phishing email generation based on users' intention or behavior may break the security system. The study results showed that big data analysis helps phishers to understand the behavior or interest of email users that can help them (phisher or hackers) to generate the phishing sites/emails to create big data security threats.
Matching Multifrequency Clinical Time Series

In this article we consider the problem of matching time sequences in the MIMIC II[1] database. Unlike other time series similarity matching problems, our task is to match time sequences of observations made at different frequencies that have been obtained from the same subject. For each time series in high-frequency, our goal is to find its low-frequency counterpart. Heart rate of each patient in the ICU is recorded by both the patient monitor automatically and by nurses manually. Series of heart rate recorded by nurses(low-frequcency clinical data) is widely applied to analysis and detection of diseases, while the high-frequency numerical data monitored by bedside monitors do not have the information needed to link it directly with clinical data. We want to match those anonymous numerical data with clinical data for future research. We studied various metrics of time series similarity and proposed two efficient metrics with high accuracies. To evaluate the performance of various metrics, synthesized unmatched pairs, along with provided matched pairs of clinical and numerical datasets, compose the training and testing set. Cross-validation is conducted to evaluate the metrics. Experiments of matching multifrequency series are conducted on the testing set. According to our experimental results, accuracy of detecting true matching is 58.80%. Higher accuracy is expected when a more efficient matching algorithm is implemented.
Living With Liver Cirrhosis: A Vulnerable Life

Liver cirrhosis is a chronic liver disease. Patients with liver cirrhosis need to manage the symptoms of the disease and possible complications. Symptoms due to ascites, encephalopathy, and/or varices are hard to manage and live with. Self-care is necessary for coping with the symptoms and for improving the patient's life situation. The aim of this study was to explore the areas of life situation and self-care among patients suffering from liver cirrhosis with complications. Interviews with patients with liver cirrhosis (n = 13), seven women and six men (46–70 years), were performed. Data were analyzed using inductive content analysis. The experience of the patient's life situation was described from two aspects: vulnerability and reflection on life. Vulnerability was expressed as symptom experience, feelings of loneliness, preconceptions, and limits in daily life. In reflection on life, the patients expressed acceptance and sadness. Self-care dealt with (a) being responsible by observing symptoms and signs; (b) adhering to treatment, prescription, and advice; and (c) the need for more understanding of and information about the disease. When caring for patients with liver cirrhosis, it is important to identify symptoms and feelings and help patients individually to maintain health through self-care.
Performance Analysis of Multi-Hop Amplify-and-Forward Relaying Systems in Rayleigh Fading Channels with a Poisson Interference Field

In this paper, we analyze the performance of multi-hop transmission systems that employ amplify-and-forward relays over a Rayleigh fading environment in the presence of a Poisson field of interferers. The interference model considers the effect of spatial distribution of co-channel interferers in the vicinity of the relays and the destination node. Using a tight upper bound on the end-to-end signal-to-interference ratio, a closed-form expression for the system outage probability is derived. Moreover, a lower bound for the average symbol error rate of general modulations, the exact average bit error rate (BER) of binary modulations and the average channel capacity are presented in the form of single-fold integrals that can be reliably evaluated numerically, whereas closed-form results are obtained for a special case of the dual-hop relaying system. Finally, asymptotic expressions for the system outage probability and the end-to-end BER are derived which provide useful insights regarding the factors affecting the performance of the considered system. The novel expressions can be used to show the impact of interference model parameters such as the transmit power, path loss exponent, and spatial density of interferers on the performance of multi-hop wireless systems. Simulation results are further provided to demonstrate the accuracy of the analytical expressions.
Waste Management Towards A Clean Environment: A Comparative Study Between Davao City-Philippines And Malang-Indonesia

This research compares the community's involvement in waste management in two cities found in the ASEAN region. The goal of this research is to find out the models that regulate waste management in Malang City in Indonesia; and Davao City in the Philippines. The aforementioned cities were chosen as locale of the study due to their similarities: both are tourism cities with functioning waste management practices. Documentation, interviews, and observations were the techniques employed in this study. It used a Constant Comparative Method to analyse the data. Findings of this research are as follows: Malang has a waste management model through a concept called Bank Sampah Malang (BSM) which is centred on community participation, while in Davao City, the model is mainly executed by the city government based on a city ordinance that outlaws littering while encouraging stakeholders to maintain a clean environment. There is a moderately significant difference in terms of budget allocation for waste management, where Davao City spends a relatively bigger budget to manage its wastes and maintain the city's cleanliness.