Miracle-dz/UniFAR-FTUs huggingface dataset:
Quadriceps Function and Patient-Reported Outcomes After Anterior Cruciate Ligament Reconstruction in Patients With or Without Knee Osteoarthritis.

CONTEXT Relationships between quadriceps function and patient-reported outcomes after anterior cruciate ligament reconstruction (ACLR) are variable and may be confounded by including patients at widely different time points after surgery. Understanding these relationships during the clinically relevant phases of recovery may improve our knowledge of specific factors that influence clinical outcomes. OBJECTIVE To identify the relationships between quadriceps function and patient-reported outcomes in patients <2 years (early) and >2 years (late) after ACLR, including those with posttraumatic knee osteoarthritis. DESIGN Cross-sectional study. SETTING Laboratory. PATIENTS OR OTHER PARTICIPANTS A total of 72 patients after ACLR: early (n = 34, time from surgery = 9.0 ± 4.3 months), late (n = 30, time from surgery = 70.5 ± 41.6 months), or osteoarthritis (n = 8, time from surgery = 115.9 ± 110.0 months). MAIN OUTCOME MEASURE(S) The total Knee Injury and Osteoarthritis Outcome Score (KOOS) and Veterans RAND 12-Item Health Survey (VR-12) were used to quantify knee function and global health. Predictors of patient-reported outcomes were involved-limb and symmetry indices of quadriceps function (isokinetic strength [peak torque, total work, average power], maximum voluntary isometric contraction torque, fatigue index, central activation ratio, Hoffmann reflex, active motor threshold) and demographics (age, activity level, pain, kinesiophobia, time since surgery). Multiple linear regression analyses were used to predict KOOS and VR-12 scores in each group. RESULTS In the early patients, knee-extensor work, active motor threshold symmetry, pain, and activity level explained 67.8% of the variance in the KOOS score ( P < .001); knee-extensor work, activity level, and pain explained 53.0% of the variance in the VR-12 score ( P < .001). In the late patients, age and isokinetic torque symmetry explained 28.9% of the variance in the KOOS score ( P = .004). In the osteoarthritis patients, kinesiophobia and isokinetic torque explained 77.8% of the variance in the KOOS score ( P = .010); activity level explained 86.4% of the variance in the VR-12 score ( P = .001). CONCLUSIONS Factors of muscle function and demographics that explain patient-reported outcomes were different in patients early and late after ACLR and in those with knee osteoarthritis.
Genetic determinants of activity and antigen levels of contact system factors

Essentials Genetic variation may provide valuable insight into the role of the contact system in thrombosis. Explored associations of genetic variants with activity, antigen, and disease in RATIO study. Two novel loci were identified: KLKB1 rs4253243 for prekallikrein; KNG1 rs5029980 for HMWK levels. Contact system variants and haplotypes were not associated with myocardial infarction or stroke.
Proximal External Aortic Compression for Life-Threatening Abdominal-Pelvic and Junctional Hemorrhage: An Ultrasonographic Study in Adult Volunteers

Abstract Introduction: Following life-threatening junctional trauma, the goal is to limit blood loss while expediting transfer to operative rescue. Unfortunately, life-threatening abdominal-pelvic or junctional hemorrhage is often not amenable to direct compression and few temporizing strategies are available beyond hemostatic dressings, hypotensive resuscitation, and balanced transfusion. Objectives: In this study, we evaluated proximal external aortic compression to arrest blood flow in healthy adult men. Methods: This was a simulation trial of proximal external aortic compression, for life-threatening abdominal-pelvic and junctional hemorrhage, in a convenience sample of healthy adult male volunteers. The primary end points were cessation of femoral blood flow as assessed by pulse wave Doppler ultrasound at the right femoral artery, caudal to the inguinal ligament. Secondary end points were discomfort and negative sequelae. Results: Aortic blood flow was arrested in 12 volunteers. Median time to blood flow cessation was 12.5 seconds. Median reported discomfort was 5 out of 10. No complications or negative sequelae were reported. Conclusion: This trial suggests that it may be reasonable to attempt temporization of major abdominal-pelvic and junctional hemorrhage using bimanual proximal external aortic compression. In the absence of immediate alternatives for this dangerous and vexing injury pattern, there appear to be few downsides to prehospital proximal external aortic compression while concomitantly expediting definite care.
DNA phosphorothioate modification—a new multi-functional epigenetic system in bacteria

Abstract Synthetic phosphorothioate (PT) internucleotide linkages, in which a nonbridging oxygen is replaced by a sulphur atom, share similar physical and chemical properties with phosphodiesters but confer enhanced nuclease tolerance on DNA/RNA, making PTs a valuable biochemical and pharmacological tool. Interestingly, PT modification was recently found to occur naturally in bacteria in a sequence-selective and RP configuration-specific manner. This oxygen–sulphur swap is catalysed by the gene products of dndABCDE, which constitute a defence barrier with DndFGH in some bacterial strains that can distinguish and attack non-PT-modified foreign DNA, resembling DNA methylation-based restriction-modification (R-M) systems. Despite their similar defensive mechanisms, PT- and methylation-based R-M systems have evolved to target different consensus contexts in the host cell because when they share the same recognition sequences, the protective function of each can be impeded. The redox and nucleophilic properties of PT sulphur render PT modification a versatile player in the maintenance of cellular redox homeostasis, epigenetic regulation and environmental fitness. The widespread presence of dnd systems is considered a consequence of extensive horizontal gene transfer, whereas the lability of PT during oxidative stress and the susceptibility of PT to PT-dependent endonucleases provide possible explanations for the ubiquitous but sporadic distribution of PT modification in the bacterial world.
Auto-Keras: Efficient Neural Architecture Search with Network Morphism

Neural architecture search (NAS) has been proposed to automatically tune deep neural networks, but existing search algorithms usually suffer from expensive computational cost. Network morphism, which keeps the functionality of a neural network while changing its neural architecture, could be helpful for NAS by enabling a more efficient training during the search. In this paper, we propose a novel framework enabling Bayesian optimization to guide the network morphism for efficient neural architecture search by introducing a neural network kernel and a tree-structured acquisition function optimization algorithm, which more efficiently explores the search space. Intensive experiments have been done to demonstrate the superior performance of the developed framework over the state-of-the-art methods. Moreover, we build an open-source AutoML system on our method, namely Auto-Keras2. The system runs in parallel on CPU and GPU, with an adaptive search strategy for different GPU memory limits.
Relevance, pathogenesis and clinical implications of thyroid disorders in children with celiac disease

Celiac disease is a frequent chronic inflammatory small bowel disease which may present itself with associated autoimmune comorbidities. Among these comorbidities, thyroid disorders show a significant prevalence; even in the pediatric population. However, the exact epidemiology and clinical significance of such alterations are yet to be fully elucidated. The most updated guidelines do not currently offer any specific support. Focusing on the pediatric population, we will review the recent available literature that we believe might be helpful in advancing the clinician’s knowledge-base regarding this issue. We also discuss which, to our knowledge, are the key pathophysiologic concepts behind the association between these two entities. Finally, we offer our own clinical perspective, recommending routine laboratory thyroid screening, possibly followed by an echographic thyroid evaluation as we believe such an approach to be appropriate when caring for children with celiac disease.
Social network properties predict chronic aggression in commercial pig systems

Post-mixing aggression in pigs is a harmful and costly behaviour which negatively impacts both animal welfare and farm efficiency. There is vast unexplained variation in the amount of acute and chronic aggression that dyadic behaviours do not fully explain. This study hypothesised that certain pen-level network properties may improve prediction of lesion outcomes due to the incorporation of indirect social interactions that are not captured by dyadic traits. Utilising current SNA theory, we investigate whether pen-level network properties affect the number of aggression-related injuries at 24 hours and 3 weeks post-mixing (24hr-PM and 3wk-PM). Furthermore we compare the predictive value of network properties to conventional dyadic traits. A total of 78 pens were video recorded for 24hr post-mixing. Each aggressive interaction that occurred during this time period was used to construct the pen-level networks. The relationships between network properties at 24hr and the pen level injuries at 24hr-PM and 3wk-PM were analysed using mixed models and verified using permutation tests. The results revealed that network properties at 24hr could predict long term aggression (3wk-PM) better than dyadic traits. Specifically, large clique formation in the first 24hr-PM predicted fewer injuries at 3wk-PM and high betweenness centralisation at 24hr-PM predicted increased rates of injury at 3wk-PM. This study demonstrates that network properties present during the first 24hr-PM have predictive value for chronic aggression, and have potential to allow identification and intervention for at risk groups.
Prokaryotic communities of Indo-Pacific giant barrel sponges are more strongly influenced by geography than host phylogeny

ABSTRACT Sponges harbor complex communities of microorganisms that carry out essential roles for the functioning and survival of their hosts. In some cases, genetically related sponges from different geographic regions share microbes, while in other cases microbial communities are more similar in unrelated sponges collected from the same location. To better understand how geography and host phylogeny cause variation in the prokaryotic community of sponges, we compared the prokaryotic community of 44 giant barrel sponges (Xestospongia spp.). These sponges belonged to six reproductively isolated genetic groups from eight areas throughout the Indo-Pacific region. Using Illumina sequencing, we obtained 440 000 sequences of the 16S rRNA gene V3V4 variable region that were assigned to 3795 operational taxonomic units (OTUs). The prokaryotic community of giant barrel sponges was characterized by 71 core OTUs (i.e. OTUs present in each specimen) that represented 57.5% of the total number of sequences. The relative abundance of these core OTUs varied significantly among samples, and this variation was predominantly related to the geographic origin of the sample. These results show that in giant barrel sponges, the variation in the prokaryotic community is primarily associated with geography as opposed to phylogenetic relatedness.
A Comparison of I/O-Efficient Algorithms for Visibility Computation on Massive Grid Terrains

Given a grid terrain T and a viewpoint v, the viewshed of v is the set of grid points of T that are visible from v. To decide whether a point p is visible one needs to interpolate the elevation of the terrain along the line-of-sight vp. Existing viewshed algorithms differ widely in what points they chose to interpolate and how they interpolate the terrain. These choices crucially affect the running time and accuracy of the algorithms. This paper describes I/O-efficient algorithms for computing visibility maps in a couple of different models. First, we describe two algorithms that sweep the terrain by rotating a ray around the viewpoint while maintaining the terrain profile along the ray. Second, we describe an algorithm which sweeps the terrain centrifugally, growing a star-shaped region around the viewpoint while maintaining the approximate visible horizon of the terrain within the swept region. Our last two algorithms are based on computing and merging horizons. All algorithms are I/O-efficient in the I/O-model of Aggarwal and Vitter. We present an experimental analysis on large terrains obtained from NASA SRTM data. All our algorithms are scalable to volumes of data that are over 50 times larger than main memory. Our main finding is that, in practice, horizons are significantly smaller than their theoretical worst case bound, which makes horizon-based approaches very fast. Our last two algorithms, which compute the most accurate viewshed, turn out to be very fast in practice, although their worst-case bound is inferior.
Hand Factors in Cardiac Development

Congenital heart defects account for 1% of infant mortality and 10% of in utero deaths. As the vertebrate embryo develops, multiple tissue types develop in tandem to morphologically pattern the functional heart. Underlying cardiac development is a network of transcription factors known to tightly control these morphological events. Members of the Twist family of basic helix–loop–helix transcription factors, Hand1 and Hand2, are essential to this process. The expression patterns and functional role of Hand factors in neural crest cells, endocardium, myocardium, and epicardium is indicative of their importance during cardiogenesis; however, to date, an extensive understanding of the transcriptional targets of Hand proteins and their overall mechanism of action remain unclear. In this review, we summarize the recent findings that further outline the crucial functions of Hand factors during heart development and in post‐natal heart function. Anat Rec, 302:101–107, 2019. © 2018 Wiley Periodicals, Inc.
Distributed Reconfiguration of Maximal Independent Sets

In this paper, we investigate a distributed maximal independent set (MIS) reconfiguration problem, in which there are two maximal independent sets for which every node is given its membership status, and the nodes need to communicate with their neighbors in order to find a reconfiguration schedule that switches from the first MIS to the second. Such a schedule is a list of independent sets that is restricted by forbidding two neighbors to change their membership status at the same step. In addition, these independent sets should provide some covering guarantee. We show that obtaining an actual MIS (and even a 3-dominating set) in each intermediate step is impossible. However, we provide efficient solutions when the intermediate sets are only required to be independent and 4-dominating, which is almost always possible, as we fully characterize. Consequently, our goal is to pin down the tradeoff between the possible length of the schedule and the number of communication rounds. We prove that a constant length schedule can be found in $O(\texttt{MIS}+\texttt{R32})$ rounds, where $\texttt{MIS}$ is the complexity of finding an MIS in a worst-case graph and $\texttt{R32}$ is the complexity of finding a $(3,2)$-ruling set. For bounded degree graphs, this is $O(\log^*n)$ rounds and we show that it is necessary. On the other extreme, we show that with a constant number of rounds we can find a linear length schedule.
Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals

Death associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine kinase; its main function is to regulate cell death. DAPK family proteins consist of DAPK1, DAPK2, DAPK3, DAPK-related apoptosis-inducing protein kinases (DRAK)-1 and DRAK-2. In this review, we discuss the roles and regulatory mechanisms of DAPK family members and their relevance to diseases. Furthermore, a special focus is given to several reports describing cross-talks between DAPKs and mitogen-activated protein kinases (MAPK) family members in various pathologies. We also discuss small molecule inhibitors of DAPKs and their potential as therapeutic targets against human diseases.
Thermal Energy Storage and Mechanical Performance of Crude Glycerol Polyurethane Composite Foams Containing Phase Change Materials and Expandable Graphite

The aim of this study was to enhance the thermal comfort properties of crude glycerol (CG) derived polyurethane foams (PUFs) using phase change materials (PCMs) (2.5–10.0% (wt/wt)) to contribute to the reduction of the use of non-renewable resources and increase energy savings. The main challenge when adding PCM to PUFs is to combine the low conductivity of PUFs whilst taking advantage of the heat released/absorbed by PCMs to achieve efficient thermal regulation. The solution considered to overcome this limitation was to use expandable graphite (EG) (0.50–1.50% (wt/wt)). The results obtained show that the use of PCMs increased the heterogeneity of the foams cellular structure and that the incorporation of PCMs and EG increased the stiffness of the ensuing composite PUFs acting as filler-reinforcing materials. However, these fillers also caused a substantial increase of the thermal conductivity and density of the ensuing foams which limited their thermal energy storage. Therefore, numerical simulations were carried using a single layer panel and the thermal and physical properties measured to evaluate the behavior of a composite PUF panel with different compositions, and guide future formulations to attain more effective results in respect to temperature buffering and temperature peak delay.
Effect of ultrasonic activation on calcium ion quantification, smear layer removal, and canal cleaning efficacy of demineralizing irrigants

Background: Effective removal of smear layer ensures better penetration of irrigants ensuring root canal disinfection and has the potential of sealing dentinal tubules during obturation. Aim: The aim of this study is to evaluate the canal cleaning efficacy and calcium ion liberation with the use of demineralizing irrigants, namely, 17% ethylenediaminetetraacetic acid (EDTA), 7% maleic acid, and 10% citric acid with or without ultrasonic (US) activation. Materials and Methods: Crowns of 62 extracted maxillary central incisors were decoronated and root canals prepared. Based on the final irrigant teeth were divided into following groups (n = 10), namely, 10% citric acid, 7% maleic acid, 17% EDTA, and 10% citric acid with US activation, 7% maleic acid with US activation, and 17% EDTA with US activation. Irrigants were subjected to inductively coupled plasma–atomic emission spectroscopy followed by debris scoring and scanning electron microscope analysis. Statistical Analysis: One-way analysis of variance with the Bonferroni's correction for multiple testing was employed. Results: About 10% citric acid with US activation liberated the highest calcium ions and removed the maximum smear layer. Conclusions: Citric acid with US activation is a potentially effective irrigation regimen with sodium hypochlorite.
Neurostimulation for the treatment of chronic migraine and cluster headache

Small subsets of patients who fail to respond to pharmacological treatment may benefit from alternative treatment methods. In the last decade, neurostimulation is being explored as a potential treatment option for the patients with chronic, severely disabling refractory primary headaches. To alleviate pain, specific nerves and brain areas have been stimulated, and various methods have been explored: deep brain stimulation, occipital nerve stimulation, and sphenopalatine ganglion stimulation are among the more invasive ones, whereas transcranial magnetic stimulation and supraorbital nerve stimulation are noninvasive. Vagal nerve stimulation can be invasive or noninvasive, though this review included only data for noninvasive VNS. Most of these methods have been tested in small open‐label patient series; recently, more data from randomized, controlled, and blinded studies are available. Although neurostimulation treatments have demonstrated good efficacy in many studies, it still has not been established as a standard treatment in refractory patients. This review analyzes the available evidence regarding efficacy and safety of different neurostimulation modalities for the treatment of chronic migraine and cluster headache.
Astrocyte dysfunction and compulsive behavior

Molecular, cellular, and circuit physiology studies identify a potential new therapeutic target for compulsive behavior disorders, involving dysfunctional neuron-astrocyte interactions within striatal microcircuits. Molecular, cellular, and circuit physiology studies identify a potential new therapeutic target for compulsive behavior disorders, involving dysfunctional neuron-astrocyte interactions within striatal microcircuits.
Airway brush cells: Not as “tuft” as you might think

CysLT3R regulates expansion of chemosensory brush cells and production of IL-25 in the airways. See related Research Article by Bankova et al. The leukotriene E4 receptor CysLT3R regulates expansion of chemosensory brush cells and production of interleukin-25 in the airways.
Cerebrospinal fluid drainage and blood pressure elevation to treat acute spinal cord infarct

Background: Current management of acute spinal cord infarction (SCI) is limited. Lumbar cerebrospinal fluid drainage (CSFD) with blood pressure augmentation is utilized in the thoracic/thoracoabdominal aortic repair and thoracic endovascular aortic repair (TEVAR) populations to increase spinal perfusion pressure. Case description: We identified 3 patients who sustained acute SCI and underwent CSFD and maintenance of elevated mean arterial pressure (MAP) within 24 hours of injury. The first patient exhibited delayed-onset ischemia after a TEVAR. The second patient presented with an acute type B aortic intramural hematoma. The third patient developed spinal cord ischemia following bronchial artery embolization. There was significant improvement in the motor examination (e.g., ASIA impairment scale grade B or C) to grade D utilizing both blood pressure augmentation and CSFD. Conclusions: Lumbar CSFD with MAP elevation benefited 3 patients with acute SCI of varying etiologies.