Miracle-dz/UniFAR-FTUs huggingface dataset:
University of Dundee Value of hospital antimicrobial stewardship programs [ ASPs ]

Background: Hospital antimicrobial stewardship programs (ASPs) aim to promote judicious use of antimicrobials to combat antimicrobial resistance. For ASPs to be developed, adopted, and implemented, an economic value assessment is essential. Few studies demonstrate the cost-effectiveness of ASPs. This systematic review aimed to evaluate the economic and clinical impact of ASPs. Methods: An update to the Dik et al. systematic review (2000–2014) was conducted on EMBASE and Medline using PRISMA guidelines. The updated search was limited to primary research studies in English (30 September 2014–31 December 2017) that evaluated patient and/or economic outcomes after implementation of hospital ASPs including length of stay (LOS), antimicrobial use, and total (including operational and implementation) costs. Results: One hundred forty-six studies meeting inclusion criteria were included. The majority of these studies were conducted within the last 5 years in North America (49%), Europe (25%), and Asia (14%), with few studies conducted in Africa (3%), South America (3%), and Australia (3%). Most studies were conducted in hospitals with 500– 1000 beds and evaluated LOS and change in antibiotic expenditure, the majority of which showed a decrease in LOS (85%) and antibiotic expenditure (92%). The mean cost-savings varied by hospital size and region after implementation of ASPs. Average cost savings in US studies were $732 per patient (range: $2.50 to $2640), with similar trends exhibited in European studies. The key driver of cost savings was from reduction in LOS. Savings were higher among hospitals with comprehensive ASPs which included therapy review and antibiotic restrictions. Conclusions: Our data indicates that hospital ASPs have significant value with beneficial clinical and economic impacts. More robust published data is required in terms of implementation, LOS, and overall costs so that decision-makers can make a stronger case for investing in ASPs, considering competing priorities. Such data on ASPs in lowerand middle-income countries is limited and requires urgent attention.
A Functional Variant of IC 53 Correlates with the Late Onset of Colorectal Cancer

Colorectal cancer (CRC) is one of the most common cancers in industrialized countries. In the United States, approximately 145,000 people are diagnosed with CRC annually, and the global figure is >875,000 (1). The genesis of CRC involves a series of steps, starting with environmental and/or endogenous carcinogens inducing or promoting cancer development via the activation of oncogenes, such as ras, and the inactivation of tumor suppressor genes, such as APC, Tp53 and DCC, and genes involved in DNA mismatch repair (2–5). Genetic factors have been reported to play a key role in the predisposition to CRC as well as in the initiation and progression of the disease. High-penetrance mutations in several genes, such as APC; and DNA mismatch repair genes, LKB1 and SMAD4, confer predispositions to familial cases of CRC (that is, familial adenomatous polyposis, Lynch syndromes and hamartomatous polyposis), which account for <5% of all CRC cases (6). However, low-penetrance variants of these and other genes, such as common alleles at single nucleotide polymorphisms (6,7), account for much of the predisposition, resulting in sporadic cases of CRC and are likely responsible for much of the uncharacterized influence of inherited genetic changes on the development of CRC. In the field of medical genetics, it has become increasingly apparent that few, if any, human diseases are homogeneous and solely the result of one mutation in a single gene. Even when a Mendelian disorder has one obvious predisposing genetic cause, the phenotype may still be subject to wide variation. The lack of a clear observed genotype/phenotype association, even in such single-gene disorders, suggests that additional modifier factors, including both environmental
Chapter 4 Gender in poli cs . Prospects and recommenda ons

Th is study focuses on the issue of participation of women in politics, particularly in the area of gender equality in governance and access to the resources associated with it. Th e results available show an increase in women’s participation in political life. Th ere are defi nitely more women applying for offi ces and many of them achieve success. Indubitably, the easily discernible progress is overshadowed by the continuing gender gap, manifested in persistent, lower participation of women. In this chapter, it is primarily quantitative data and reports that have been considered, and analysis of the results available enables us to present the changes in the representation of women in political decision-making circles both at the national and supra-national levels. We have analysed the data describing the situation in Poland, the Nordic countries, and the European Union. In the context of initiatives for equal representation of women in representative bodies exercising functions and decision-making, it is worth noting that, even in countries which have achieved a satisfactory level in terms of numbers, this is not fully refl ected in the implementation of gender equality in the area of politics. Th is is because the practice, oft en used, is to limit access to certain areas of political activism. Th ere is still a well-established social, stereotypical division into areas traditionally “reserved” for representatives of both sexes, such as social aff airs or education.
Sveučilište u Zagrebu Prehrambeno-biotehnološki fakultet Preddiplomski studij Prehrambena tehnologija Andrea Buratović 6817/PT SPEKTROFOTOMETRIJSKO ODREĐIVANJE POLIFENOLA U ACETONSKIM EKSTRAKTIMA RUŽMARINA (Rosmarinus officinalis) ZAVRŠNI RAD Predmet: Analitička kemija Mentor: Doc. dr.sc. Ant

Due to the fact that few scientific papers have shown that plant extracts could be used as potential corrosion inhibitor, the object of this work was preparation of acetone rosemary extracts, which will be used in further process of anticorrosion testing. Therefore, in this work was prepared acetone (30 and 70 %, v/v) extracts of rosemary by ultrasound extraction, at time of 3,6 and 9 min and amplitude of 60, 80 and 100 %. The extraction by refluxing, at time of 1,5 and 3 h was applied, too. Mass fraction of total phenols and flavonoids in prepared extracts was determined by UV/Vis spectrophotometry. On the basis of obtained results, the optimal conditions of ultrasound extraction (70 % acetone, 100 % amplitude and time of 9 min) was determined, and will be used in further preparation of extracts for examination of theirs anticorrosion action.
Knowledge Diversity , Coherence and Out-licensing of Knowledge : An Innovation Process Perspective

During the last decades outward knowledge licensing (OKL) has become considerably important in business practice. In the biotech industry, OKL has evolved to a sustainable business model. Despite this development OKL has received less academic attention. This paper addresses an extensive research gap by analyzing the impact firm? s knowledge diversity and coherence on OKL from a dynamic innovation process perspective. Hypothesizes are developed by combining knowledge based view with the new product development framework and arguments form licensing literature. We employ a unique project based dataset from the pharmaceutical industry, comprising the innovation project portfolio of 280 pharmaceutical firms. Applying zero inflated negative regression models, our results suggest a positive relationship between knowledge diversity and OKL at the firm level as well as at the level of single innovation phases. For knowledge coherence a negative effect is proven also at the firm and the phase level.
uinolone-related Achilles Tendinopathy in Heart Transplant atients : Incidence and Risk Factors

ackground: A high incidence of Achilles tendinopathy—tendinitis or rupture—has been observed after quinolone treatment in lung and kidney transplant patients. In the absence of relevant published data, we aimed to determine its incidence, clinical features, risk factors and outcome among heart graft recipients. ethods: We studied the clinical records of all adult heart transplant patients who were prescribed quinolones at our center between August 1995 and September 2006. Achilles tendinopathy had been diagnosed clinically, with ultrasound assessment when necessary. In all cases, quinolone treatment had been terminated upon diagnosis of tendinopathy. esults: During this period, quinolones had been given on 242 occasions to 149 heart transplant patients (33 women, 116 men). Achilles tendinopathy developed on 14 occasions (5.8%; 95% confidence interval: 2.8% to 8.7%), affecting 13 men and 1 woman (mean age: 62 years). Three cases involved tendon rupture, and bilateral tendinopathy was present in 8 cases. The median time between the start of treatment and onset of symptoms was 2.5 days, with 12 patients being asymptomatic 2 months after drug withdrawal. Independent risk factors for tendinopathy were renal dysfunction (p 0.03) and increased time between transplantation and treatment (p 0.005). Incidence was not influenced by the type, dose or previous administration of quinolones, or by the immunosuppressive regimen. onclusions: Quinolone-related Achilles tendinopathy is frequent among heart transplant patients, especially in the presence of renal dysfunction or lengthy post-transplantation survival. If no alternative anti-bacterial therapy is available for high-risk patients, close clinical surveillance should be warranted. J Heart Lung Transplant 2008;27:46–51. Copyright © 2008 by the International Society for Heart and Lung Transplantation.
Recurrent Neural Network Architectures for Sub-Optimal Motion Generation : A Recue Robot Case Study

Recurrent Neural Network Architectures for Sub-Optimal Motion Generation: A Recue Robot Case Study by Seonggyun Park Department of Mechanical and Aerospace Engineering Seoul National University Rescue robots typically consist of one or more manipulators mounted on a mobile platform,and must operate in complex and unstructured environments with limited power. As such, motion planning for such high-dimensional systems must be done in close to real-time, producing motions that are efficient and meet all
Marmara Üniversitesi

We have been witnessing two profound transformations since the late 1970’s ; one in the academy particularly in social sciences, and the other in the world economic system. The transformation within the academy involves a paradigm shift in social sciences, as the neoclassical economic theory constitutes the dominant paradigm in social theory. The transformation within the world economic system involves the globalization of capitalism. In this article the question I would like to address is whether or not the 1 EGE University, Faculty of Economics and Administrative Siences, Dept. of Economics, Bornova/Izmir, Turkey. E.mail: menevis.uzbay@ege.edu. tr Yrd. Doç. Dr. Meneviş UZBAY PİRİLİ 72 transformations at the economic level – capitalism becoming a global system, on the one hand, and the absorption of academic discourses in social sciences into the neoclassical economical paradigm on the other, is a mere coincidence? And if not, what are the implications of the parallels between the academy and material life. Section 1 involves explanation of neoclassical paradigm. Section 2 examines the new subdisciplines in social sciences. Section 3 addresses globalization of capitalism. The Conclusion is a discussion about the possible ways of looking at the similarities between what is happening within the academy and in the world.
A PRELIMINARY BIM IMPLEMENTATION FRAMEWORK FOR CONSULTANT QUANTITY SURVEYOR FIRMS IN A DEVELOPING COUNTRY

The benefits of Building Information Modelling (BIM) have been widely promoted but the implementation of BIM in developing country such as Malaysia is still at its infant stage. Quantity take-off or Measurement remained as one of the major consultant Quantity Surveyors’ tasks in Malaysia as most of construction projects are still implementing traditional procurement and contract with quantities. With the implementation of BIM, most of the quantities can be easily abstracted from 3D models and several parties believed that Quantity Surveyors’ profession in Malaysia will have to face challenges in future. Therefore, this paper aims to create a BIM implementation framework for consultant quantity surveyor firms based on identified BIM constraints via questionnaire survey. Online questionnaires were distributed to registered Quantity Surveyors in Malaysia based on the Board of Quantity Surveyors Malaysia (BQSM) official website company list to collect professional feedbacks from Quantity Surveyors in order to strengthen the research findings. Based on the questionnaire, it was found out that the software constraints, communication constraints and lack of standard & rules are significantly affecting the BIM implementation in Malaysia. Based on the questionnaire findings, a preliminary BIM implementation framework for consultant QS firms has been created to improve the current BIM implementation in Malaysia. Additionally, a semi-structure interview was conducted in purposing a preliminary framework for quantity surveyors in implementing BIM in Malaysia. This framework serves as a guidance for consultant Quantity Surveyors to enhance their BIM knowledge and business strategy in implementing BIM in future.
Induction of Apoptosis and Autophagy Using Ectopic D SCR 1 Expression in Breast Cancer Cells

Down syndrome critical region 1 gene (DSCR1) is an anti-angiogenesis gene that inhibits the growth of tumor cells. In this study, the role of autophagy and apoptosis in DSCR1-induced cytotoxicity were investigated in MDA-MB-468 breast cancer cells. Lentivirus vector harboring DSCR1 (LV-DSCR1) was constructed in HEK 293 cells and the optimal dosage of lentivirus vector for infection was determined by the MTT assay. After infection of cells using LV-DSCR1, acridine orange and ethidium bromide staining was performed to investigation of apoptosis and autophagy. Expression of DSCR1 and marker genes for angiogenesis (VEGF), apoptosis (Bax and Bcl2) and autophagy (LC3 and Beclin) were determined by Real time PCR. The cellular morphological changes related to apoptosis and autophagy was happened after 48 hours of viral infection. Fragmented bright orange nucleuses and vacuoles were observed due to the cell apoptosis and autophagy after acridine orange and ethidium bromide staining. Upregulation of Bax, Lc3, DSCR1 and Beclin1 and downregulation of Bcl2 and VEGF was detected due to treatment with LV-DSCR1. These results demonstrated that LVDSCR1 can induce apoptosis and autophagy, therefore suggesting that it may serves as an efficient tool to breast cancer treatment.
ControLLing the diStribution oF eLePhAntS 7

The general impression left on my mind was that, with civilization closing in on all sides, ultimately something must be done to segregate the game areas from those used for farming; otherwise sooner or later some excuse for liquidation of the wild animals will be found . North of the Letaba River the country West of the Park consists mainly of native locations and areas. Here the Park itself might be fenced off.
Acute-Toxicity , Anti-Inflammatory and Bronchial Smooth Muscles Investigation of Sisymbrium Irio Linn ( Seeds ) in Experimental Animal Models

Sisymbriumirio Linn (Seeds) are used in folk medicine for a treatment of inflammation, arthritis, expectorant, stimulant and asthma. ,externally used as stimulating poultice.Acute toxicity study of Sisymbriumirio Linn seeds was performed on mice (Swiss) and albino rats (Wistar strain),given single doses 10,100,200,500 and 1000mg/kg,po. showed normal behavior and no mortality up to 14 days. Sisymbriumirio Linn seeds (100-200x7days or 100-200x3days or 50-200mg/kg,po single dose ),pretreatment time , 60 min showed significant sub-acute anti-inflammatoryprotection against Cotton pellet induced granuloma formation, no analgesic activity,decreased swim stress immobility in mice indicating some degree of antidepressant activity.Sisymbriumirio Linn seeds protected guinea-pigs against bronchospasm induced by histamine aerosol. The steroids, glycosides , alkaloids, and flavonoids present in the plant appear to be of chemotherapeutic interest.
Circulating miR-200 c and miR-141 and outcomes in patients with breast cancer

Background: The deregulation of microRNAs in both tumours and blood has led to the search for microRNAs to indicate the presence of cancer and predict prognosis. We hypothesize the deregulation of miR-200c/miR-141 in the whole blood can identify breast cancer (BC), and could be developed into a prognostic signature. Methods: The expression of miR-200c and miR-141 were examined in bloods (57 stage I-IV BC patients and 20 age-matched controls) by quantitative reverse-transcription PCR. The associations of circulating microRNAs with clinic and pathological characteristics were analysed. Their effects on survival were analysed by the Kaplan-Meier method and Cox regressions. Results: MiR-200c was down regulated (P < 0.0001) in the blood of BC patients, yielded an area under the ROC curve of 0.79 (90% sensitivity, 70.2% specificity) in discriminating BC from controls. Circulating miR-141 was not discriminating. MiR-200c and miR-141 in the blood of BC patients were inversely correlated (P = 0.019). The miR-200c levels were numerically higher in stage IV and tumours with lower MIB-1. MiR-141 was significantly higher in the blood of patients with stage I-III, lymph node metastasis, and HER2 negative tumours. High blood expression of miR-200c and/or low expression of miR-141 was associated with unfavourable overall survival (hazard ratio, 3.89; [95% CI: 1.28-11.85]) and progression-free survival (3.79 [1.41–10.16]) independent of age, stage and hormonal receptors. Conclusions: Circulating miR-200c and miR-141 were deregulated in BC comparing with controls. Furthermore, miR-200c and miR-141 were independent prognostic factors and associated with distinct outcomes of BC patients.
Design of feedback insensitive InP ring laser

The optical isolators used to protect semiconductor lasers against optical feedback cannot be integrated. Therefore we propose to fabricate a laser that has a strongly reduced sensitivity to feedback. Simulations show that such a device can be realized by employing a ring laser in which the clockwise and counter-clockwise modes are not coupled. To achieve unidirectional lasing, this work proposes to use an intra cavity weak optical isolator based on two phase modulators that are driven 90 degrees out of phase. Simulations show up to 3% of intensity feedback can be tolerated without any distinguishable effect on the laser light.
A Retrofitted Palm Oil Mill Effluent Treatment System for Tapping Biogas

Malaysia being one of largest oil palm producing and exporting country. On average, a palm oil mill produces 0.65m 3 of palm oil mill effluent (POME) for every ton of fresh fruit bunch (FFB) processed. Knowing that treatment of POME would release biogas containing mainly methane and carbon diode, POME becomes one of the best agricultural renewable sources for biogas production as compared with other feedstock produced in Malaysia. The conventional POME treatment system has no capability to tap the released biogas. A revised treatment process is suggested that is retrofitting the conventional POME treatment system for tapping the biogas emission resulting from POME treatment and subsequently used it as green sustainable energy source for achieving zero green effect. From the study, tapping 97% purity of methane gas from 50% biogas released from approximately 0.65m 3 of POME produced from every ton of fresh fruit bunch (FFB) with the retrofitted POME treatment system is achievable.
Developing Effective Top Management Team at Vietnamese SMEs

Despite an increasing number of studies focusing on leadership at Vietnamese small and medium sized enteprises (SMEs), there is a lack of empirical research on collective leadership and development of effective top management team (TMT). The purpose of this paper is to review the literature with a view of characteristics forming an effective TMT. Taking the team effectiveness theory, upper echelons theory and behavioral theory of the firm, theoretical characteristics of effective TMT was created, and then an empirical research was conducted on a sample of 141 SMEs. The common characteristics of an effective TMT are identified, including shared vision, optimal team size, role clarity, age diversity, functional background diversity, regular communication, solidarity and collective decision making. The study makes several contributions to the existing literature on effective TMT development at SMEs.
ANALISIS AUDIO WATERMARKING BERBASIS STATIONARY WAVELET TRANSFORMATION

Abstrak Kita telah memasuki era dimana informasi bisa disebarluaskan dalam bentuk digital. Berbagai macam informasi entah itu dalam bentuk teks, audio, citra, maupun audio kini dapat dengan mudah diunggah dan diakses oleh berbagai kalangan dengan cepat dan mudah. Namun juga tidak sedikit oknum yang menyalahgunakan kelebihan ini untuk kepentingannya sendiri, tidak terkecuali file dalam bentuk audio yang akan dibahas pada jurnal ini. Audio menjadi salah satu bentuk file yang paling banyak dilanggar hak ciptanya, seperti proses pengambilan sebagian (resampling) sebagai contoh yang paling umum. Karena itu, jurnal ini memberikan solusi agar dapat mencegah terjadinya pelanggaran tersebut, dengan menggunakan metode watermarking. Watermarking adalah proses penyisipan file sebagai tanda atau copyright tanpa merusak file aslinya. File yang disisipkan pada jurnal ini berupa citra dengan audio sebagai file host. Metode yang akan digunakan pada tugas akhir ini antara lain Stationary Wavelet Transformation (SWT), dengan metode penyisipan Spread Spectrum (SS), dan dioptimasi menggunakan algoritma genetika. Spread Spectrum adalah metode penyisipan dengan hasil dimana watermark akan disisipkan pada frekuensi rendah sehingga lebih sulit untuk dideteksi. Algoritma genetika digunakan untuk menentukan parameter evaluasi kualitas yang akan dimodifikasi sehingga data watermark masih memiliki imperceptibility dan robustness yang baik. Diimplementasikan menggunakan MATLAB, audio akan diuji dengan dua macam serangan yaitu resampling, dan kompresi MP3. Setalah dilakukan pengujian akan dilanjutkan dengan optimasi menggunakan Algen. Dari pengujian tersebut akan didapatkan parameter keluaran dari masing-masing lima jenis audio dengan diberikan dua macam serangan tersebut. Dari proses tersebut akan didapatkan parameter keluaran, yaitu ODG, SNR, BER dan C.
Tilburg University Connection Situations under Uncertainty

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