Miracle-dz/UniFAR-FTUs huggingface dataset:
Toward the Development of Iteration Procedures for the Interval-Based Simulation of Fractional-Order Systems

In recent years, numerous interval-based simulation techniques have been developed which allow for a verified computation of outer interval enclosures for the sets of reachable states of dynamic systems represented by finitedimensional sets of ordinary differential equations (ODEs). Here, especially the evaluation of IVPs is of interest, when both the systems’ initial conditions and parameters can only be defined by finitely large domains, often represented by interval boxes. Suitable simulation techniques make use of series expansions of the solutions of IVPs with respect to time and (possibly) the uncertain initial conditions as well as of verified Runge-Kutta techniques. Solution sets are then typically represented by means of multi-dimensional intervals, zonotopes, ellipsoids, or Taylor models, cf. [5]. In most of these approaches, variants of the Picard iteration [1] are involved, which either determine the sets of possible solutions or at least worst-case outer enclosures with which time discretization errors are quantified. An example for a solution routine based entirely on this iteration is the exponential enclosure technique published in [9] and the references therein. It is applicable to systems with nonoscillatory and oscillatory behavior if the solution of the IVP of interest shows an asymptotically stable behavior. For non-oscillatory
IV Ketamine Infusions for the Treatment of Depression: An Evidence Based Practice Analysis

According to the World Health Organization, major depressive disorder (MDD) is a mental health condition which affects a significant portion of the worldwide population and is projected to become the leading cause of disability by 2020.1 There are several treatment options for the diagnosis of depression, with the most popular being antidepressant drugs such as the selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs); and electroconvulsive therapy (ECT). The significant drawbacks to the current treatments are the extended timeframe required for drugs to reach therapeutic efficacy and resistance to ECT over time. These disadvantages can lead to increased risk of self-harm and suicidal tendencies. A drug with fast onset and efficacy in treating depression can improve patient’s quality of life.
Expression of CD24 in prostate cancer tissues and its clinical significance

[摘 要] 目的:探讨CD24在前列腺癌组织中的表达及其与前列腺癌患者临床病理特征的关系。 方法 选取 2016年 2月至 2019年3月福建医科大学附属泉州第一医院泌尿外科手术切除的40例新鲜前列腺癌组织及相应的36例癌旁组织,46例前列腺 增生组织标本取自TURP手术患者。 通过流式细胞术检测 40例前列腺癌、36例癌旁前列腺组织、46例前列腺增生组织标本中 CD24的表达水平;运用单因素方差分析CD24的表达量与前列腺癌患者的年龄、肿瘤分布情况、术前血清PSA含量、术后Gleason 评分、临床分期和是否远处转移之间的关系。 结果: 前列腺癌中CD24的阳性表达率及平均荧光强度(MFI)值均明显高于癌旁 前列腺组织和良性前列腺增生组织(均P<0.05);术前血清PSA≥10 ng/ml、术后Gleason评分≥8分(低分化)、临床分期T4期和远处 转移的前列腺癌组织中CD24的阳性细胞率及MFI值均明显高于对应组(均P<0.05);且CD24的表达随着术后Gleason评分及临 床分期的进展而逐渐增加(P<0.05)。 结论:CD24在前列腺癌组织中的表达增加,检测CD24的表达水平可协助判断前列腺癌的 发生、发展及侵袭转移等情况,具有潜在的临床应用价值。 [关键词] 前列腺癌;CD24;侵袭;转移 [中图分类号] R730.45; R737.25 [文献标识码] A [文章编号] 1007-385X(2019)12-1383-04
GENEALOGICAL PERSPECTIVE OF THE LULUHYIA DIALECTS’ LEXICOSYNTACTIC SIMILARITIES

The syntactic similarity of given languages may be used as evidence of their genealogical relatedness. This paper focuses on the lexicosyntactic similarities inherent across the Luluhyia dialects as evidence of their common origin. Despite the principle of language universals as advanced by Naom Chomsky leading to universal grammar (UG), not all languages of the world ascribe to the same syntactic structure. The findings of the study presented in this paper show that the Luluhyia dialects have the same syntactic structure as a result of the similarities of their lexical items. Such syntactic similarities across the Luluhyia dialects are an indicator of a once linguistically and anthropologically unified community whose origin was undisputedly one. The Luluhyia dialects use basically the same words only differing in pronunciation, stress placement and vowel length. In most cases, the distinction between the Luluhyia dialects cannot be detected by non-native speakers of the dialects. The variations are mostly suprasegmental in nature. However, the relatedness of the Luluhyia dialects is overtly displayed prompting a genealogical connection.
Forbs of coffee plantations: taxonomically identify, chemical evaluation and evaluate the behavior of free range lambs

The goal of this work was to taxonomically identify di erent species of forbs that grow in co ee plantations, analyze their chemical composition and evaluate the behavior of free range lambs compared to animals grazing in pasture. The taxonomic classi cation was done in both the rain and dry season. The whole plantation was studied while the animals grazed. All the existing plant species were registered, observed and separated between those ones eaten by the animals, which were called selected forbs, and the no eaten ones, called rejected ones. Chemical composition and in vitro and in situ digestibility were studied as well as the grazing ovine behavior, which was closely observed. 58 di erent plant species were found, belonging mainly to the Fabaceae, Mimosaceae, Caesalpinaseae, Gramineae and Asteraceae families. The selected forbs and grass fodder showed: 14 and 7.8 % CP; 45.9 and 47.7 % NDF(p < 0.05); 3.2 and 2.3 Mcal GE(p < 0.05); a=9.3 and 8.8, b= 74.3 and 74.6 c= 61.1a and 60.4 respectively. The feed intake frequency of the animals grazing in the co ee plantation was higher and produced no damage to the leaves, branches, stems nor beans. In conclusion, there is more feed diversity in co ee plantations than in pastures and animals are capable to select those fodders of better nutritional quality without producing any damage to the co ee
A novel endosymbiont-containing trypanosomatid Phytomonas borealis sp. n. from the predatory bug Picromerus bidens (Heteroptera: Pentatomidae).

Here we describe the new trypanosomatid, Phytomonas borealis sp. n. , from the midgut of the spiked shieldbugs, Picromerus bidens (Linnaeus), collected in two locations, Novgorod and Pskov Oblasts of Russia. The phylogenetic analyses, based on the 18S rRNA gene, demonstrated that this flagellate is a sister species to the secondary monoxenous Phytomonas nordicus Frolov et Malysheva, 1993, which was concurrently documented in the same host species in Pskov Oblast. Unlike P. nordicus, which can complete its development (including exit to haemolymph and penetration into salivary glands) in Picromerus bidens, the new species did not form any extraintestinal stages in the host. It also did not produce endomastigotes, indispensable for transmission in other Phytomonas spp. These observations, along with the fact that P. bidens overwinters at the egg stage, led us to the conclusion that the examined infections with P. borealis were non-specific. Strikingly, the flagellates from the Novgorod population contained prokaryotic endosymbionts, whereas the parasites from the second locality were endosymbiont-free. This is a first case documenting presence of intracellular symbiotic bacteria in Phytomonas spp. We suggest that this novel endosymbiotic association arose very recently and did not become obligate yet. Further investigation of P. borealis and its intracellular bacteria may shed light on the origin and early evolution of endosymbiosis in trypanosomatids.
Effects of Social Media Usage on Social Integration of University Students

Social media is important for college students to expand social capital. This study examines how different uses of social media contribute to students’ social capital and social integration. The findings show that communicative use, academic collaboration, and self-disclosure on social media significantly predict bridging capital, but they are not positively related to bonding capital. Both bridging and bonding social capital are significant predictors of social integration. This study provides insights about how to use social media to promote students’ social integration during their transition to college.
Cation−π Interaction in Model α-Helical Peptides

Cation−π interactions are increasingly recognized as important in chemistry and biology. Here we investigate the cation−π interaction by determining its effect on the helicity of model peptides using a combination of CD and NMR spectroscopy. The data show that a single Trp/Arg interaction on the surface of a peptide can make a significant net favorable free energy contribution to helix stability if the two residues are positioned with appropriate spacing and orientation. The solvent-exposed Trp→Arg (i, i + 4) interaction in helices can contribute −0.4 kcal/mol to the helix stability, while no free energy gain is detected if the two residues have the reversed orientation, Arg→Trp (i, i + 4). The derived free energy is consistent with other experimental results studied in proteins or model peptides on cation−π interactions. However in the same system the postulated Phe/Arg (i, i + 4) cation−π interaction provides no net free energy to helix stability. Thus the Trp→Arg interaction is stronger than Phe→Arg. T.
Gene Expression and Proteomic Profiling of Lp (a)-Induced Signalling Pathways in Human Aortic Valve Interstitial Cells

Aortic valve stenosis is one of the most common valve diseases in the world for which there is currently no pharmacological treatment to prevent or halt disease progression. Recent genetic research has demonstrated a causal association between elevated blood levels of lipoprotein (a) (Lp (a)) and aortic valve calcification, however, the mechanisms by which Lp (a) contributes to aortic valve calcification and stenosis, is unknown. In the present study, we aimed at determining Lp (a)-induced changes in human aortic valve interstitial cells using an integrated bioinformatics approach. The Lp (a)-induced cellular pathways were analysed using microarray gene expression and proteomic data from non-stenotic human aortic valve interstitial cells. Lp (a) treatment induced osteogenic differentiation, extracellular remodeling, extracellular vesicles biogenesis, and apoptosis of human aortic valve interstitial cells. In particular, the Wnt/ β-catenin signalling pathway, a known calcification pathway contributing to aortic valve stenosis, was differentially expressed compared to non-treated cells. Lp (a) also induced the expression of 14-3-3 proteins known to regulate various signalling pathway relevant to aortic valve disease. Elucidating the mechanisms and molecular players that Lp (a) induces in the early stages of the disease to initiate aortic valve calcification could provide insight into potential pharmacological targets for the treatment of this debilitating disease.
Cyclosporine in Stevens–Johnson syndrome and toxic epidermal necrolysis: Current scenario

S syndrome (SJS) and toxic epidermal necrolysis (TEN) represent the acute, severe, and life‐threatening forms of adverse cutaneous drug reactions clinically presenting as “acute skin failure. ”[1] The cornerstone in the management of these conditions is the supportive treatment promptly addressing the various cutaneous and systemic consequences of acute skin failure by a multidisciplinary approach. In addition, specific treatment modalities also need to be considered to halt the disease progression. Many specific treatment modalities have been employed in SJS/TEN including systemic steroids, intravenous immunoglobulins (IVIG), thalidomide, and cyclosporine. The main issue is the lack of objective validation for the use of any of these modalities due to the lack of blinded randomized controlled trials for various practical and ethical reasons. Hence, currently, the use of any specific treatment modality in SJS/TEN is at the discretion of the treating physician.
Anticonvulsive effects of nifedipine and flunarizine on maximal electroshock seizures induced seizures

Background: Epilepsy is a common neurological disorder but the mechanism of seizure generation has been only partially unraveled. Currently available antiepileptics have a low therapeutic index and furthermore, provide satisfactory seizures control in only 6070% of patients. Therefore, the present study was done to review the basic mechanism of seizures with special attention on voltage gated calcium channels and search for new antiepileptic in order to improve the efficacy of current therapies. Aims and Objective: The current study aimed to evaluate the anticonvulsant activity of calcium channel blockers. Materials and Methods: The animals were treated with Nifedipine (100 μg/100 g ip and 200 μg/100 g ip) and Flunarizine (5mg ⁄ kg ip and 10 mg⁄kg ip) and maximal electroshock seizures (MES) was induced by technoelectro convulsometer, 2 hrs after the administration of drugs, and duration of various phases were noted. Duration of tonic hind limb extension (THLE) was taken as index for antiepileptic activity. Result: Nifedipine and Flunarizine when administered in dose of 100 μg/100 g ip and 5 mg/kg respectively did not produce any changes in any phases of the MES induced seizure. But in dose of 200 μg/100 g ip and 10 mg/kg ip respectively, it significantly reduced the duration of THLE. Conclusion: Nifedipine and Flunarizine have a significant action against MES induced seizures suggesting an important role of CCBs as future, promising antiepileptic drug.
Prolonged western equine encephalitis viremia in the Texas tortoise (Gopherus berlandieri).

: Subcutaneous inoculation of 34 Texas tortoises (Gopherus berlandieri) with either of two strains of Western Equine Encephalitis (WEE) virus resulted in prolonged viremia of up to 105 days' duration. Peak viremia titers exceeded 10(6) suckling mouse intracranial lethal doses per milliliter. The length of the previremic period, the maximum viremia level attained, and the duration of viremia were markedly affected by environmental temperature. Higher temperatures (30 degrees C) shortened the previremic period and the duration of viremia and elevated the maximum viremia level. Lower temperatures had the opposite effect. Mechanisms are suggested whereby Texas tortoises could serve as an overwintering reservoir for WEE virus at any temperature. Neutralizing antibody was detectable following viremia in only 11 of 16 (69%) of surviving tortoises.
Pesticide Side Effects in an Agricultural Soil Ecosystem as Measured by amoA Expression Quantification and Bacterial Diversity Changes

Background and Methods Assessing the effects of pesticide hazards on microbiological processes in the soil is currently based on analyses that provide limited insight into the ongoing processes. This study proposes a more comprehensive approach. The side effects of pesticides may appear as changes in the expression of specific microbial genes or as changes in diversity. To assess the impact of pesticides on gene expression, we focused on the amoA gene, which is involved in ammonia oxidation. We prepared soil microcosms and exposed them to dazomet, mancozeb or no pesticide. We hypothesized that the amount of amoA transcript decreases upon pesticide application, and to test this hypothesis, we used reverse-transcription qPCR. We also hypothesized that bacterial diversity is affected by pesticides. This hypothesis was investigated via 454 sequencing and diversity analysis of the 16S ribosomal RNA and RNA genes, representing the active and total soil bacterial communities, respectively. Results and Conclusion Treatment with dazomet reduced both the bacterial and archaeal amoA transcript numbers by more than two log units and produced long-term effects for more than 28 days. Mancozeb also inhibited the numbers of amoA transcripts, but only transiently. The bacterial and archaeal amoA transcripts were both sensitive bioindicators of pesticide side effects. Additionally, the numbers of bacterial amoA transcripts correlated with nitrate production in N-amended microcosms. Dazomet reduced the total bacterial numbers by one log unit, but the population size was restored after twelve days. The diversity of the active soil bacteria also seemed to be re-established after twelve days. However, the total bacterial diversity as reflected in the 16S ribosomal RNA gene sequences was largely dominated by Firmicutes and Proteobacteria at day twelve, likely reflecting a halt in the growth of early opportunists and the re-establishment of a more diverse population. We observed no effects of mancozeb on diversity.
Carotid Intima Media Thickness Measurements in Nigerian Pre-dialysis CKD Patients

1 Nephrology unit, Federal Teaching Hospital, Abakaliki, Nigeria 2 Radiation Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria 3 Nephrology Unit, University Of Nigeria Teaching Hospital, Enugu, Nigeria Corresponding Author Afolabi OF. Nephrology Unit, Federal Teaching Hospital, Abakaliki, Nigeria Email: olaronke.afolabi@yahoo.com, Phone +2348136494979 Abstract Background: Cardiovascular disease complications are the commonest causes of mortality in patients with Chronic Kidney Disease (CKD). Carotid intima-media thickness (CIMT) measurements provide information on arterial wall thickness. This study explores CIMT in CKD patients. Methods: one hundred and seven pre-dialysis CKD patients were consecutively recruited. Eighty one healthy subjects served as control. A pre-tested questionnaire was administered and physical examination done. Fasting blood samples were collected. CIMT was measured using high resolution B mode ultrasonography at 3 sites the distal common carotid artery, the internal carotid artery and the carotid bulb. The mean value was calculated. Results: CIMT was significantly increased in CKD patients. Mean CIMT among CKD patients was 0.120 ± 0.015mm and 0.092 ± 0.034mm in controls, p<0.001. CIMT correlated significantly with age, eGFR, creatinine level, triglyceride level, and history of diabetes. Serum creatinine however best predicted CIMT. There was no correlation between CIMT and total cholesterol, HDL, LDL, calcium phosphate product and blood pressure in the CKD patients. Conclusion: CIMT is increased in CKD patients suggesting that carotid atherosclerosis is more prevalent in them. It is recommended that CIMT measurements be done in our CKD patients to identify patients at high risk of cardiovascular episodes for possible intervention.
Tracking Human Mobility Using WiFi Signals

We study six months of human mobility data, including WiFi and GPS traces recorded with high temporal resolution, and find that time series of WiFi scans contain a strong latent location signal. In fact, due to inherent stability and low entropy of human mobility, it is possible to assign location to WiFi access points based on a very small number of GPS samples and then use these access points as location beacons. Using just one GPS observation per day per person allows us to estimate the location of, and subsequently use, WiFi access points to account for 80% of mobility across a population. These results reveal a great opportunity for using ubiquitous WiFi routers for high-resolution outdoor positioning, but also significant privacy implications of such side-channel location tracking.
Some effects of patch food environments on copepods

Laboratory determinations of the time taken for copepods to starve to death and of the effects of discontinuous food availability on egg production are used to demonstrate that different species are adapted to different scales of patchiness in their food environment. Acartia tonsa and Centropages typicus depend on constant food availability and are therefore sensitive to small scales of patchiness, whereas Pseudocalanus minutus and Calanus finmarchicus can physiologically remove themselves from such small-scale variability. The success of these organisms in the natural environment may be related to the length of time that layers of food exist in the water column.
Atherothrombosis as a Leading Cause of Acute Coronary Syndromes and Stroke: The Main Killers in Developed Countries

Worldwide, cardiovascular incidents are estimated to cause 17.5 million deaths, 80% of which are ischemic strokes or acute coronary syndromes. Cardiovascular disease results in a significant financial burden for healthcare system—namely, in 2009, it was 9% of the gross health service expenditure in the European Union. Therefore, the development of the knowledge about atherosclerosis—initially thought to be solely degenerative disor - der but now considered a multifactorial inflammatory state—is essential. Acute coronary syndrome (ACS) is usually a manifestation of severe reduction in coronary blood flow caused by atherosclerotic plaque and thrombus. The pathology of the atherosclerotic plaque is complex. Essentially, it is disease of the arterial intima that, through subse - quent stages, results to luminal narrowing. Over the years, various theories regarding the genesis growth and vulnerability of atherosclerotic lesions have been promoted, usually focusing on endothelial injury, smooth muscle cell proliferation, lipid accumulation, and, more recently, inflammatory reactions. in relation to the platelets which by releasing granulation substances (IL-1β) activate the endothelial cells creating a mutual feedback. Reactive oxygen species (ROS) and circulating lipoprotein (oxy-LDL) also express endothelial surface adhesion proteins as selectins (P-sel) and von Willebrand factor (VWF), which supports the mutual relationships between them and platelets. Platelet CD40 ligand (CD40L) binds CD40 on endothelial cells, resulting in upregulation of adhesive molecules (ICAM-1, VCAM-1, P-sel), cytokines, and TF release, leading to reduction in NO synthesis. Surface platelets glycoprotein-1 receptors for P-selectin (PSGL-1) allow for adhesive bond and rolling platelets but not strict binding to the endothelium. Glycoprotein surface receptor GPVI and αvβ3 bind vascular walls collagen causing the activation of receptors αIIbβ3 and release of ADP and thromboxane A2 (TxA2). The combination of glycoprotein platelet receptors αIIbβ3 with VWF and fibrinogen stabilizes the platelet clot. This initiates a platelet thrombus protruding into artery lumen and is essential for the later stages of thrombus formation.
Recurrent Thromboembolism in Infants and Children Suffering From Symptomatic Neonatal Arterial Stroke

Background and Purpose— The present study was performed to evaluate the rate of recurrent symptomatic thromboembolism with respect to prothrombotic risk factors and underlying clinical conditions. Methods— In a series of 215 consecutively enrolled neonates with arterial ischemic stroke (AIS), the factor V G1691A mutation, factor II G20210A variant, methylenetetrahydrofolate reductase (MTHFR) T677T genotype, lipoprotein (Lp) (a), antithrombin, protein C, protein S, and anticardiolipin antibodies (ACA) were investigated. Patient median follow-up was 3.5 years (range, 1 to 8 years). Results— During follow-up, 7 infants and children (3.3%) showed recurrent symptomatic thromboembolism (AIS, n=4; venous sinus thrombosis, n=2; deep vein thrombosis of the leg, n=1). The factor V mutation, factor II variant, elevated Lp(a) >30 mg/dL, protein C deficiency, and protein S or antithrombin deficiency were associated with first stroke onset. In 5 of 7 cases (71.4%), prothrombotic risk factors [MTHFR T677T, elevated Lp(a.