Miracle-dz/UniFAR-FTUs huggingface dataset:
Acceptance in the Domestic Environment: The Experience of Senior Housing for Lesbian, Gay, Bisexual, and Transgender Seniors

The social environment impacts the ability of older adults to interact successfully with their community and age-in-place. This study asked, for the first time, residents of existing Lesbian, Gay, Bisexual, and Transgender (LGBT) senior living communities to explain why they chose to live in those communities and what, if any, benefit the community afforded them. Focus groups were conducted at 3 retirement communities. Analysis found common categories across focus groups that explain the phenomenon of LGBT senior housing. Acceptance is paramount for LGBT seniors and social networks expanded, contrary to socioemotional selectivity theory. Providers are encouraged to develop safe spaces for LGBT seniors.
Bayamon SVC project in Puerto Rico

The Puerto Rico Electric Power Authority (PREPA) suffered a major power plant failure in Palo Seco in late 2006, this necessitated import of power from the south of the Island. System studies indicated that to import reasonable amount of power from South, during the peak load conditions (during the summer), the transmission system would need dynamic reactive power support. The network planners were facing a severe problem with potential voltage stability in the area, and decided that the most expedient solution to the problem while the power plant was being refurbished was an SVC rated at 0/+90 Mvar. The Bayamon SVC was designed, delivered and installed in record time, and this paper presents the design of the SVC, which had very challenging requirements for the control system.
A Pyrosequencing assay for the detection of EZH2Y641 mutations in diffuse large B cell lymphoma and follicular lymphoma

Aims: Enhancer of Zeste Homolog 2 (EZH2) is a critical enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), which provides inhibitory regulation of gene transcription through trimethylation of histone H3 on lysine 27 (H3K27me3). The somatic mutation EZH2 Y641 in its highly conserved catalytic SET domain has been reported in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) by methods of Sanger sequencing and whole exome sequencing. To develop a clinically applicable assay uses pyrosequencing method for accurate detection of EZH2Y641 mutations in formalin- fixed-paraffin-embedded (FFPE) tissue. Methods: We validated the pyrosequencing method for the detection of EZH2 Y641 mutation in DLBCL cell lines. We also screened a cohort of 43 DLBCL and 12 FL cases by pyrosequencing, and correlated with the results of Sanger sequencing of EZH2 exon 15. Results: We detected EZH2 Y641 mutations in 3/22 (13.6%) germinal center B cell-like DLBCL, 2/12 (16.7%) FL and none of the 21 activated B cell-like DLBCL. The mutations detected by pyrosequencing were in complete agreement with Sanger sequencing. We have identified the most common 4 types of mutations of EZH2 Y641. Conclusion: The rapid and accurate detection of the EZH2 mutation fromFFPE tissue sections in the clinical laboratory will facilitate screening patients with DLBCL and FL for enrollment of clinical trials using EZH2 inhibitors.
On state-dependent channels with non-memoryless state information at the transmitter

We consider a state dependent channel with a state sequence which is a stationary and ergodic process known non-causally to the transmitter. We first establish a multi-letter formula for the capacity of this single-user channel. We show that among all the stationary-ergodic state sequences having the same single symbol distribution, the i.i. d. one is the worst. We present an example in which the capacity of the channel controlled by a Markov chain state sequence is strictly higher than that of the same channel with an i.i. d. state sequence having the same stationary distribution. We conclude by demonstrating that in the setup of a cognitive channel with an interférer, one can benefit in terms of reliably transmitted rates if the interférer uses random coding schemes with memory rather than i.i. d. ones.
Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia.

CONTEXT Convergent data make 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) a candidate gene for schizophrenia. Reduced expression has been reported in the schizophrenic brain. The CNP gene maps to a region to which we have reported linkage to schizophrenia. Mice in which the CNP gene has been knocked out display central nervous system pathological characteristics reminiscent of some features observed in schizophrenia. 2',3'-Cyclic nucleotide 3'-phosphodiesterase is used as a marker of myelin-forming cells and is detectable in cells of oligodendrocyte lineage throughout life. Because CNP is thought to be important for oligodendrocyte function, altered expression has been interpreted as supportive of the hypothesis that altered oligodendrocyte function may be an etiological factor in schizophrenia. However, it is unclear whether the observed changes in the schizophrenic brain are primary or secondary. OBJECTIVES To determine if CNP expression is influenced by DNA polymorphisms and to verify if these polymorphisms are associated with schizophrenia. DESIGN Allele-specific messenger RNA expression assay and genetic association studies. SETTING Unrelated subjects were ascertained from secondary psychiatric inpatient and outpatient services. PARTICIPANTS We used brain tissue from 60 anonymous individuals with no known psychiatric disorder; a case-control sample of 708 white individuals from the United Kingdom meeting DSM-IV criteria for schizophrenia matched for age, sex, and ethnicity to 711 blood donor controls; and a pedigree with DNA from 6 affected siblings and 1 parent, showing evidence for linkage to CNP. MAIN OUTCOME MEASURES Association between allele and gene expression. Association between allele and schizophrenia. RESULTS The exonic single nucleotide polymorphism rs2070106 was associated with CNP expression (P<.001). Compatible with underexpression of CNP messenger RNA in schizophrenia, the lower-expressing A allele was significantly associated with schizophrenia (P = .04) in the case-control sample. All affected individuals in the linked pedigree were homozygous for the lower-expression allele, providing independent support for the association (P = .03). CONCLUSIONS Our data support the hypothesis that reduced CNP expression in the schizophrenic brain is relevant to disease etiology and therefore provide support for the general hypothesis that altered oligodendrocyte function is an etiological factor in schizophrenia.
Broadband dual-polarized planar antenna and array for mobile communication base station

A broadband dual-polarized planar antenna element for mobile communication base station is presented in this paper. It is formed by two crossed modified dipoles printed on a substrate and supported upon a reflector by four nylon posts. Simulated and measured bandwidth with VSWR<;1.4 are 49% (1.68-2.77 GHz) and 57% (1.63-2.93 GHz), respectively, within which the polarized isolation is better than 28 dB. It is simple and easy to be fabricated. A 9-element dual-polarized electrical downtilt array is designed. It can realize 2° to 13° electrical downtilt with sidelobe reduced below -16 dB.
Wideband Four-Way Filtering Power Divider With Sharp Selectivity and Wide Stopband Using Looped Coupled-Line Structures

A compact wideband four-way filtering PD is presented. The structure of the proposed device includes a pair of looped coupled-line structures to provide the needed power division to four output ports. Moreover, a pair of short-ended coupled-line stubs is used to introduce multiple transmission poles and transmission zeros for a sharp cut-off of the passband and high upper-stopband rejection. A detailed design procedure is shown to determine the initial design parameters. A prototype is designed, simulated and measured experimentally. The measured results show 56.5% bandwidth centered at 1.5 GHz with more than 15 dB upper-stopband rejection up to 4.15 GHz, more than 13 dB in-band isolation, and 15 dB return loss at all output ports.
Practical implementation of adaptive gain and variable gain super-twisting algorithms on the magnetic levitation system: A comparative study

This paper describes the practical implementation of two well known robust control strategies over a non-linear magnetic levitation system for controlling the coil current so as to achieve the desired position. In order to make the controller robust and practically implementable, higher order sliding modes (HOSM) technique is used. Two second order sliding modes (SOSM) schemes are applied on the actual setup, based on adaptive gain super-twisting algorithm (AGSTA) and variable gain super-twisting algorithm (VGSTA). The sliding surface proposed is a linear combination of the error in coil current and its derivative. An extensive performance comparison study for both the proposed controllers on magnetic levitation system is carried out keeping the desired objective same for both the controllers. The robustness of the proposed controllers is validated in presence of disturbances and parametric uncertainties. The required control efforts to achieve the desired performance are tabulated.
Comparison of Neurocognition Between Drug-Free Patients With Schizophrenia and Bipolar Disorder

It is often difficult to make a differential diagnosis between schizophrenia and bipolar disorder because of the overlapping symptoms. The patients of both disorders have been shown to have neurocognitive deficits. In this study, a computerized battery of neurocognitive tasks, COGLAB, was administered to four participant groups: 30 patients with positive schizophrenia, 22 patients with negative schizophrenia, 27 patients with bipolar disorder, and 28 normal controls. All the patients were drug-free for at least 1 month. The tasks included Mueller-Lyer illusion, reaction time, size estimation, a variant of the Wisconsin Card Sorting Test, backward masking, and Asarnow continuous performance. Discriminant analyses were used to investigate the differences among the four groups. Results indicated that COGLAB correctly classified 73.5% of the cases of negative schizophrenia and bipolar disorder. The best discriminative tasks were card sort, Asarnow continuous performance, and backward masking. The results of this study were also compared with results of a previous study with medicated patients. Neurocognitive tasks had better discriminative power for medicated patients with schizophrenia and bipolar disorder than for drug-free patients. Moreover, medication effects did not seem to significantly change the pattern of the neurocognitive task responses of patients with schizophrenia.
Sexual dimorphism of hepatic gene expression: novel biological role of KRAB zinc finger repressors revealed.

Significant physiological differences between the sexes exist, and underlying these differences are sex-dependent genetic regulatory events that are ultimately dictated by the sex chromosome genotype of the organism. For example, it has been known for many decades that the mammalian liver is a sexually dimorphic organ, exhibiting major sex differences in the profile of steroid and drug metabolism (Yates et al. 1958; Colby 1980). The physiological requirements for steroid hydroxylation differ between the sexes, and accordingly, many enzymes involved in steroid metabolism, most notably steroid hydroxylases belonging to the cytochrome P450 superfamily (Nelson 1999, 2003), are expressed in the liver in unique, sex-dependent patterns during postnatal and pubertal development (Waxman 1988; Shapiro et al. 1995). These sex differences are most dramatic in rodents, but may occur in humans as well, where they have an impact on cytochrome P450-catalyzed drug metabolism and pharmacokinetics (Jaffe et al. 2002; Meibohm et al. 2002). Early studies established that growth hormone (GH), acting via its sex-dependent patterns of pituitary hormone secretion, is a major player in establishing and maintaining the sexual dimorphism of hepatic gene transcription that emerges in rodents at puberty (Gustafsson et al. 1983; Norstedt and Palmiter 1984). These patterns are ultimately determined by neonatal exposure to testosterone, which imprints on the hypothalamus the male program of neuroendocrine control of pulsatile pituitary GH secretion that is first seen at puberty and continues through adulthood (Jansson et al. 1985). The underlying molecular mechanisms that govern the sexdependent expression of hepatic cytochromes P450 and other enzymes, and their regulation by plasma GH profiles, are proposed to involve the stimulatory action of the signal transducer and transcriptional activator STAT5b, but are only partially understood (Waxman 2000; Schwartz 2001). Major new insight is provided by the discovery, reported in this issue of Genes & Development, of a pair of KRAB (Kruppel-associated box) zinc finger genes, termed Rsl1 and Rsl2, that can exert strong repression of male-specific hepatic gene expression in both males and females (Krebs et al. 2003). This repression is partially relieved in males at puberty in response to pulsatile GH signaling, greatly accentuating adult sex differences in gene expression.
Detection and interaural time discrimination of a sinusoid masked by interaurally delayed white noise.

Masking‐level differences and masked interaural time jnds were measured for a 560‐ and a 1000‐Hz tone‐burst signal. The masker, a diotic white noise, was interaurally time delayed by amounts ranging from no delay to one full period of the signal frequency. Results show that the size of the jnd varies systematically with the masking‐level difference. Those masker delays which most benefit detection cause poorer signal interaural time discrimination.
Serum inflammatory proteins and cognitive decline in older persons

Objective: To assess whether serum levels of the inflammatory proteins α1-antichymotrypsin (ACT), C-reactive protein (CRP), interleukin-6 (IL-6), and albumin are associated with cognitive decline in older persons. Methods: The study sample consisted of 1,284 participants in the Longitudinal Aging Study Amsterdam, aged 62 to 85 years. Cognition was assessed on general cognition (Mini-Mental State Examination [MMSE]), memory (Auditory Verbal Learning Test), fluid intelligence (Raven’s Colored Progressive Matrices), and information-processing speed (Coding Task) at baseline and at 3-year follow-up. Results: The highest tertile of ACT was associated with an increased risk of decline on the MMSE (age-, sex-, education-adjusted odds ratio [OR] 1.60; 95% CI: 1.05 to 2.43) but not on any other cognitive test score. CRP, IL-6, and albumin were not associated with cognitive decline on any cognitive test in our study. Conclusions: This population-based study showed that the serum inflammatory protein α1-antichymotrypsin is associated with cognitive decline in older persons, whereas C-reactive protein, interleukin-6, and albumin are not.
Netrin Stimulates Tyrosine Phosphorylation of the UNC-5 Family of Netrin Receptors and Induces Shp2 Binding to the RCM Cytodomain*

Caenorhabditis elegans UNC-5 and its mammalian homologues such as RCM are receptors for the secreted axon guidance cue UNC-6/netrin and are required to mediate the repulsive effects of UNC-6/netrin on growth cones. We find that C. elegans UNC-5 and mouse RCM are phosphorylated on tyrosinein vivo. C. elegans UNC-5 tyrosine phosphorylation is reduced in unc-6 null mutants, and RCM tyrosine phosphorylation is induced by netrin-1 in transfected HEK-293 cells, demonstrating that phosphorylation of UNC-5 proteins is enhanced by UNC-6/netrin stimulation in both worms and mammalian cells. An activated Src tyrosine kinase induces phosphorylation of RCM at multiple cytoplasmic tyrosine residues creating potential binding sites for cytoplasmic signaling proteins. Indeed, the NH2-terminal SH2 domain of the Shp2 tyrosine phosphatase bound specifically to a Tyr568 RCM phosphopeptide. Furthermore, Shp2 associated with RCM in a netrin-dependent manner in transfected cells, and co-immunoprecipitated with RCM from an embryonic mouse brain lysate. A Y568F mutant RCM receptor failed to bind Shp2 and was more highly phosphorylated on tyrosine than the wild type receptor. These results suggest that netrin-stimulated phosphorylation of RCM Tyr568 recruits Shp2 to the cell membrane where it can potentially modify RCM phosphorylation and function.
Hospital discharge rates for suspected acute coronary syndromes between 1990 and 2000: population based analysis

Although hospital discharge rates for acute myocardial infarction are falling,1–4 no contemporary studies compare temporal trends in these rates for angina and other types of chest pain. We examined recent trends in population discharge rates for myocardial infarction, angina, and chest pain (“suspected acute coronary syndromes”) between 1990 and 2000. We got data from the Scottish morbidity record for Scottish residents aged at least 18 years with a “first” emergency hospitalisation for myocardial infarction (codes ICD-9 (international classification of diseases, ninth revision) 410, ICD-10 I21 or I22), angina (ICD-9 411 or 413; ICD-10 I20 or I24.9) or “other chest pain” (ICD-9 786.5; ICD-10 R07), between 1990 and 2000.5 We analysed discharges coded only in the principal position. A “first” hospitalisation was one with no discharge diagnosis of coronary heart disease or chest pain in the previous 10 years. We calculated rates using annual official age and sex specific population estimates for 1990-2000 and tested the significance of …
Bacterial repopulation of drinking water pipe walls after chlorination

Abstract The short-term kinetics of bacterial repopulation were evaluated after chlorination of high-density polyethylene (HDPE) colonized with drinking water biofilms and compared with bare HDPE surfaces. The effect of chlorination was partial as a residual biofilm persisted and was time-limited as repopulation occurred immediately after water resupply. The total number of bacteria reached the same levels on both the bare and chlorinated biofilm-fouled HDPE after a seven-day exposure to drinking water. Due to the presence of a residual biofilm, the hydrophobicity of chlorinated biofilm-fouled surface exhibited much lower adhesion forces (2.1 nN) compared to bare surfaces (8.9 nN). This could explain the rapid repopulation after chlorination, with a twofold faster bacterial accumulation rate on the bare HDPE surface. γ-Proteobacteria dominated the early stages of repopulation of both surfaces and a shift in the dominance occurred over the colonization time. Such observations define a timescale for cleaning frequency in industrial environments and guidelines for a rinsing procedure using drinking water.
Screening for musculoskeletal causes of pelvic pain.

The Musculoskeletal System As A Source of Pelvic Dysfunction Chronic pelvic pain has long frustrated both a wide range of medical specialists and countless patients. In the past, research consistently demonstrated three general themes: the high numbers of women affected; the high percentage of misdiagnoses; and the extreme failure rates of medical intervention. Recent work, however, has begun to show more successful results, reflecting a broader understanding of the multifaceted nature of chronic pelvic pain. This improvement appears to be related to a changed approach (ie, a multidisciplinary model of patient care in contrast to earlier compartmentalized treatment). As women with complaints of pelvic pain often present with urologic, gynecologic, gastrointestinal, neurologic, or musculoskeletal symptoms, the first step is to establish an accurate diagnosis. It may not be within the purview of the examiner to treat all the possible causes; however, all examiners can possess the knowledge to recognize many types of dysfunction, even those in areas outside their specialty, and to assist in recommending appropriate treatment. Research has shown that the musculoskeletal system is involved in disorders such as vulvodynia, coccygodynia, levator ani syndrome, fibromyalgia, endometriosis, vulvar vestibulitis syndrome, dyspareunia, vaginismus, pelvic floor tension myalgia, urgency–frequency syndrome, interstitial cystitis, urethral syndrome, irritable bowel syndrome, and pudendal nerve entrapment/pudendal neuralgia. Whether musculoskeletal dysfunction is a primary cause of symptoms or an effect of pathology elsewhere, it is crucial that it be addressed to achieve a successful outcome. Therefore, the purpose of this report is to broaden clinicians’ perspective of chronic pelvic pain to include the musculoskeletal system; to provide them with tools to perform a preliminary musculoskeletal examination; and to enable them to educate the patient about Correspondence: Stephanie A. Prendergast, MPT, Pacific Center for Pelvic Pain and Dysfunction, 1199 Bush Street, Suite 650 San Francisco, CA 94109. E-mail: stephanie@jmweissmd.com CLINICAL OBSTETRICS AND GYNECOLOGY Volume 46, Number 4, 773–782 © 2003, Lippincott Williams & Wilkins, Inc.
Cartografar a identidade corporal Diálogo entre arte, pedagogia e ciência Ferramentas audiovisuais (primeiro passo)

O projeto em desenvolvimento que aqui se apresenta – identificar e analisar a acao perceptiva-motora utilizando instrumentos digitais de imagem (captacao e tratamento) – operacionaliza um dialogo interdisciplinar entre formacao teatral e neurociencias, mais propriamente, entre a pedagogia do Corpo e do Movimento Cenico como os conhecimentos da Ciencia Cognitiva - area da percepcao visual do movimento humano.
FEM Model of Wraparound CNTFET With Multi-CNT and Its Capacitance Modeling

The wraparound gate carbon nanotube field-effect transistor (CNTFET) has the advantage of more accurately controlled channel than the top-gate CNTFET. A 3-D simulation is performed using the finite-element method (FEM) to model the wraparound CNTFET with multi-CNT channels. Analytical expressions to model various capacitances of the same device are also derived from capacitances for the 1-D FET with multiple cylindrical conducting channels incorporating screening effect due to multiple CNT. Various capacitances thus obtained exhibit remarkable improvement over the planar top-gate device with multiple conducting channels. This is attributed to the charge enhancement and the better charge confinement in the channel of the wraparound CNTFET with multi-CNT channels. Capacitances are also extracted from the proposed FEM model. The extracted capacitances are in excellent agreement with the capacitances obtained from the analytical model presented in this study.
Assessment of the cost associated with wind generation prediction errors in a liberalized electricity market

In this paper, a probabilistic methodology for estimating the energy costs in the market for wind generators associated with wind prediction errors is proposed. Generators must buy or sell energy production deviations due to prediction errors when they bid in day-ahead or hour-ahead energy markets. The prediction error is modeled through a probability density function that represents the accuracy of the prediction model. Production hourly energy deviations and their associated trading costs are then calculated. Three study cases based on real wind power installations in Spain are analyzed. The three study cases show that the error prediction costs can reach as much as 10% of the total generator energy incomes.