Miracle-dz/UniFAR-FTUs huggingface dataset:
The correlation between spontaneous contractions and postjunctional supersensitivity of the smooth muscle of the rat vas deferens.

Chronic postganglionic denervation of the rate vas deferens produces an increase in the sensitivity of the in vitro smooth muscle to norepinephrine, methoxamine, acetylcholine, potassium and electrical stimulation. The maximal contractile response to norepinephrine and acetylcholine is increased but the maximal response to potassium or electrical stimulation is not affected. In addition, the vas deferens becomes spontaneously active after denervation. The spontaneous contractions are not prevented by tetrodotoxin, phentolamine or atropine. The appearance and magnitude of the spontaneous contractions are temporally correlated with the development of postjunctional supersensitivity. At a given time after denervation there is a significant correlation between the magnitude of the spontaneous contractions and the sensitivity to norepinephrine, i.e., the sensitivity to norepinephrine being greatest in those tissues with the largest spontaneous contractions. There is an inverse relationship between the magnitude of the spontaneous contractions and the endogenous norepinephrine concentration. Pretreatment of rats with reserpine (1. 0 mg/kg/day for 5-7 days) results in supersensitivity of the vas deferens ,o norepinephrine and acetylcholine. Those tissues obtained from reserpine-pretreated rats which are supersensitive are also spontaneously active. It is concluded that the -ppearance of spontaneous contractions in the rat vas deferens is an index of postjunctional supersensitivity.
Competitive recovery of the small business sector through understanding its role and essence: regional aspects

The article considers some problems concerned with efficiency of state regulation and small business (SB) support in Russia taking into account the change of its essence and role, including the issues at the regional level. Currently in Russia and abroad, theoretical insights devoted to SB essence have a certain specificity aimed mainly at underlining some positive aspects of small business. But modern realities prove the need to review the theoretical insights in the aftermath of the radical transformation of Russian economy, which occurred in recent years and caused an increase in shadow economic activity of small enterprises. At the same time, the domestic economy ceased to be closed one and gradually became an integral part of the global economy. The fact predetermines the further development of Russian economy based on digital technologies, being an important factor for regional economy. It is also necessary to emphasize that, despite the variety of the theoretical problems raised within the study of SB theory, there is a lack of attention paid to its essence transformation in the context of shadow activity of small enterprises. Also, speaking about applied researches, inadequate share of attention is paid to the methods of state influence on shadow activity of small businesses that is connected directly with delegation of authorities and responsibilities to regional and municipal levels during state support implementation.
Analyse de la stabilité des ouvrages souterrains par une méthode cinématique régularisée

Cette these traite le probleme de la stabilite des ouvrages souterrains creuses en terrain meuble a faible profondeur. La stabilite de ce type d'ouvrages est normalement etudiee en utilisant des methodes justifiees par l'experience mais dont les hypotheses ne sont pas toutes coherentes au plan mecanique. L'application systematique du calcul a la rupture et de l'analyse limite fournit des encadrements pour les chargements conduisant a la rupture d'un systeme donne. Le memoire decrit la mise en oeuvre numerique d'une forme regularisee de l'approche cinematique de l'analyse limite pour l'etude de la stabilite des ouvrages souterrains. La resistance des sols est modelisee par des criteres de Tresca, de Tresca tronque en traction et de Mohr-Coulomb en conditions bidimensionnelles, et par des criteres de Tresca et de Mohr-Coulomb pour les calculs tridimensionnels. Les calculs reproduisent les modes de rupture observes dans les travaux souterrains et sur modeles. Les charges limites calculees sont voisines des valeurs experimentales.
Thread tension control of permanent magnet synchronous motor based on load torque observer

Thread tension control is a highly challenging issue that has not been well resolved so far in embroidery industry. In this paper, a novel closed-loop controller was proposed for control of thread tension for embroider systems. First, the mathematical model was constructed by load observers was designed to estimate the thread tension in real-time. Secondly, a classical PI controller was developed to implement speed tracking control, where load torque provided by a torque-observer was employed as a feed-forward disturbance compensation to improve the robustness of the controller. Finally, the closed-loop controller for control of thread tension was derived. Simulation results demonstrated the effectiveness of the proposed observers and the control scheme.
Impact of CYP2D6 Poor Metabolizer Phenotype on Propranolol Pharmacokinetics and Response

We conducted an open‐label study to determine the impact of cytochrome P‐4502D6 (CYP2D6) on propranolol pharmacokinetics and response in 12 healthy men with CYP2D6 extensive metabolizer (EM) phenotype and 3 healthy men with CYP2D6 poor metabolizer (PM) phenotype. Subjects received R,S‐propranolol hydrochloride 80 mg every 8 hours for 16 doses. After the sixteenth dose, blood and urine samples were collected for 24 hours, and serum propranolol and urine metabolite concentrations were determined by chiral high‐performance liquid chromatography. Heart rate response to treadmill exercise was measured serially over 24 hours. Apparent oral clearance of propranolol and partial metabolic clearance values of propranolol to 4‐hydroxypropranolol (HOP), propranolol glucuronide, and naphloxylactic acid (NLA) were estimated. Apparent oral clearance and elimination half‐life of propranolol were not different between EMs and PMs. Partial metabolic clearance of propranolol to HOP was significantly higher and to NLA was significantly lower in EMs than in PMs. No differences in percentage reductions in exercise heart rate were observed between EMs and PMs. The CYP2D6 PM phenotype has no effect on propranolol blood concentrations and does not alter response to propranolol. Our data also suggest that CYP2D6 mediates approximately 65% and 70% of S‐ and R‐propranolol's 4‐hydroxylation, respectively.
Aspirin plus clopidogrel and risk of infection after coronary artery bypass surgery.

BACKGROUND The risks associated with the use of the combination of aspirin and clopidogrel before surgery are incompletely understood. Pharmacologic suppression of platelet function may increase the risk of postoperative infection by inhibiting hemostasis, immunity, or both. METHODS We performed a retrospective cohort study of 1677 patients undergoing coronary artery bypass surgery to determine the relationship of the preoperative use of aspirin plus clopidogrel vs aspirin alone to the 30-day incidence of postoperative surgical site infection and bacteremia. RESULTS The cumulative incidence of infection at 30 days was 23.1% and 16.1% in patients who were receiving dual antiplatelet therapy and aspirin monotherapy, respectively (unadjusted hazard ratio [HR], 1.51; 95% confidence interval [CI], 1.09-2.08). The risk of infection remained higher among patients who were receiving dual antiplatelet therapy after adjustment for demographic, socioeconomic, preoperative, and intraoperative risk factors (HR, 1.42; 95% CI, 1.01-2.00) and propensity score (HR, 1.43; 95% CI, 1.01-2.01]). Transfusion rates were also higher among patients who were receiving dual antiplatelet therapy than among patients who were receiving aspirin monotherapy (68.4% vs 60.4%, P = .04), but transfusion played a modest role in mediating the risk of infection (adjusted HR, 1.37; 95% CI, 0.96-1.93]). Mortality rates at 30 days were 5.2% and 3.1% in patients who were receiving dual antiplatelet and aspirin monotherapy, respectively (adjusted HR, 1.44; 95% CI, 0.70-2.99]). CONCLUSIONS Preoperative use of aspirin plus clopidogrel is associated with an increased risk of infection after coronary artery bypass surgery. These findings merit additional work to clarify the risks and benefits of uninterrupted dual antiplatelet therapy in surgical patients and the impact of platelet inhibition on infectious outcomes in populations that are at heightened infectious risk.
Dystrophic Fat Lipoplasty in HIV Patients . Focus on lower Limb Lipodystrophy and Introduction of Fat Assisted Body Sculpturing ( FABS )

Background: With increasing prevalence of acquired immune deficiency syndrome (AIDS) and improved prognosis of patients due to chronic use of highly active antiretroviral therapy (HAART), multiple adverse effects have been also reported, especially lipodystrophy. This study was done to check the effectiveness of fat assisted body sculpturing for lipodystrophy in HIV positive patients. Methods: Between October 2010 and October 2013, 125 patients (85 females and 40 males) who presented with lipodystrophy of lower limbs, underwent liposuction with fat assisted body sculpturing (FABS). Mean age and seropositivity history were of 44 and 17 years, respectively. Results: A questionnaire was given to all 125 patients, to asses patient’s satisfaction for the results obtained at the end of the follow-up period a 1 to 5 scale was allocated to each parameter. For persistence of volumetric correction at 1 year, the score 3, 4 and 5 was given by 25, 76 and 24 patients, respectively. For overall surgical experience, the score 3, 4 and 5 was given by 32, 75 and 18 patients, respectively. The majority of patients expressed satisfaction for the management of lipodystrophy. The great majority of the patients scored 4 (good result). Conclusions: Patients demanding volume adjustments found that FABS is an effective method for adipose tissue manipulation and further studies in the future will clarify the findings of the present study.
ACID EFFECT ON GROWTH AND FLOWERING OF A JANIA PACIFICA / N AKAI / B REMER

The research addressed the effect of gibberellic acid (GA3) on growth and flowering of Ajania pacifica /Nakai/ Bremer et Humphries ‘Bea’. The vegetative growth lasted for 8 weeks in glasshouse, under natural long day and from August 15 under natural short day. The plants were divided into four groups: 1 the plants sprayed with distilled water (control combination); 2, 3 and 4 the plants sprayed with GA3 ones, twice and thrice, respectively, starting from the 5 th week of growth, and then in the 6 th and 7 th week, successively. Each of the group was divided into two subgroups: the first one treated with GA3 at concentration of 250 mg·dm -3 and the second with 500 mg·dm -3 . It was observed that double spraying with GA3 accelerated the buds development of Ajania pacifica, thus shortened the cultivation time by about two days. Treatment with GA3 at concentration 500 mg·dm -3 stimulated the elongation of shoots more than treatment with GA3 at 250 mg·dm -3 . The plants sprayed twice were longer than the control and then those sprayed one time. However, elongation of shoots was not remarkable; corymbs were shorter, narrower, and contained lesser number of inflorescences. The present study indicates the specificity of the response of Ajania pacifica to GA3 treatment, which appears to be different from other ornamental species.
Big Data in Health Care System

---The healthcare sectors have grown rapidly in the last few decades. The healthcare industry provides facilities to the patients with medicinal, precautionary, reassuring care, etc. Thus, a huge volume of data is generated. A long time ago when the computers were not in use, this data was stored in the hard copy form. But now the current trend is rapid digitalization. Big data consists of a large amount of data which cannot be stored and processed using the traditional approach. This paper basically studies the implementation techniques of the big data in the healthcare sector. This paper also implies the challenges and tools to implement big data in the healthcare sector. It also discusses different machine learning algorithms that are useful for maintaining the trade-off between accuracy and efficiency. [1]
CORD: Contention Resolution by Delay Lines

The implementation of optical packet-switched networks requires that the problems of resource contention, signalling and local and global synchronization be resolved. A possible optical solution to resource contention is based on the use of switching matrices suitably connected with optical delay lines. Signalling could be dealt with using subcarrier multiplexing of packet headers. Synchronization could take advantage of clock tone multiplexing techniques, digital processing for ultra-fast clock recovery, and new distributed techniques for global packet-slot alignment. To explore the practical feasibility and effectiveness of these key techniques, a consortium was formed among the University of Massachusetts, Stanford University, and GTE Laboratories. The consortium, funded by ARPA, has three main goals: investigating networking issues involved in optical contention resolution (University of Massachusetts), constructing an experimental contention-resolution optical (CRO) device (GTE Laboratories), and building a packet-switched optical network prototype employing a CRO and novel signaling/synchronization techniques (Stanford University). This paper describes the details of the project and provides an overview of the main results obtained so far.
Universal Approximation Using Radial-Basis-Function Networks

There have been several recent studies concerning feedforward networks and the problem of approximating arbitrary functionals of a finite number of real variables. Some of these studies deal with cases in which the hidden-layer nonlinearity is not a sigmoid. This was motivated by successful applications of feedforward networks with nonsigmoidal hidden-layer units. This paper reports on a related study of radial-basis-function (RBF) networks, and it is proved that RBF networks having one hidden layer are capable of universal approximation. Here the emphasis is on the case of typical RBF networks, and the results show that a certain class of RBF networks with the same smoothing factor in each kernel node is broad enough for universal approximation.
Design of a reference model based approach to support business-IT alignment improvement in co-creation value networks

review was based on the defined inclusion criteria, respectively: published in a peerreviewed journal or conference proceedings; included all types of studies (embracing empirical research, conceptual papers, and literature reviews); a study had sufficient quality i.e., it is at the least based on expert opinions [212], the context of VN is clearly mentioned in the abstract; and contained indications of VN-CKM processes. The abstract review process resulted in the selection of the final set of 23 articles to be used for data analysis. Step 2) Data analysis Here, data analysis in relation to SLR 1 is explained. The same process was followed for SLR 2 (it can be found in [20]). The objective of this data analysis was a text analysis of each selected article to identify and extract relevant information (quotes). Given this objective, the selected articles were analyzed using content analysis approach [249]. Content analysis is a structured method for analyzing and organizing descriptive data into a structured format [249]. This data analysis was done in a two-step process: identification and extraction. In the identification step, relevant quotes were identified by text analysis of each article. A quote was retrieved from the articles if it was the main result of scientific research and if it was relevant. The quote was considered as relevant if it described explicitly VN-CKM process with sufficient-detailed information. Following this process, out of 23 sources, nine articles contained relevant quotes. From these articles a total of 33 quotes were identified. In the extraction step, the identified quotes were extracted in structured way. For doing this, a data extraction form was designed which was based on the designed structure of a KM process model (Table 4.5). Whenever a quote was relevant to VN-CKM process characteristics, the form was completed. The quote was extracted literally from the original article (e.g., part 2 in Table 4.5). To develop the content (e.g., part 3 in Table 4.5), first, a type of process and sub-process should be identified and filled in the form. For this, a decision was made based on the context of the quote. Subsequently, kernel aspects of the quote were used to provide content to the characteristics (part 3 in Table 4.5). It should be noted that for each sub-process, first, the outcome of the sub-process was considered. If the type of activity, control and resource, required for fulfilling such an outcome, were available, then the kernel aspects of a quote were positioned into the structure. If information was missing in the quote, sometimes a characteristic was left open (e.g., formal control in Table 4.5), while at other times a kernel aspect of a quote at a higher abstraction level was added to the characteristic in the table (e.g., network actors as a resource in Table 4.5).
Identification of Clinically Significant Tumor Antigens by Selecting Phage Antibody Library on Tumor Cells in Situ Using Laser Capture Microdissection*S

Much work has been done to develop tumor-targeting antibodies by selecting a phage antibody library on cancer cell lines. However, when tumor cells are removed from their natural environment, they may undergo genetic and epigenetic changes yielding different surface antigens than those seen in actual cases of cancer. We developed a strategy that allows selection of phage antibodies against tumor cells in situ on both fresh frozen and paraffin-embedded tissues using laser capture microdissection. By restricting antibody selection to binders of internalizing epitopes, we generated a panel of phage antibodies that target clinically represented prostate cancer antigens. We identified ALCAM/MEMD/CD166, a newly discovered prostate cancer marker, as the target for one of the selected antibodies, demonstrating the effectiveness of our approach. We further conjugated two single chain Fv fragments to liposomes and demonstrated that these nanotargeting devices were efficiently delivered to the interior of prostate cancer cells. The ability to deliver payload intracellularly and to recognize tumor cells in situ makes these antibodies attractive candidates for the development of targeted cancer therapeutics.
A simpler solution of the non-uniqueness problem of the covariant Dirac theory

Although the standard generally-covariant Dirac equation is unique in a topologically simple spacetime, it has been shown that it leads to non-uniqueness problems for the Hamiltonian and energy operators, including the non-uniqueness of the energy spectrum. These problems should be solved by restricting the choice of the Dirac gamma field in a consistent way. Recently, we proposed to impose the value of the rotation rate of the tetrad field. This is not necessarily easy to implement and works only in a given reference frame. Here, we propose that the gamma field should change only by constant gauge transformations. To get that situation, we are naturally led to assume that the metric can be put in a space-isotropic diagonal form. When this is the case, it distinguishes a preferred reference frame. We show that by defining the gamma field from the "diagonal tetrad" in a chart in which the metric has that form, the uniqueness problems are solved at once for all reference frames. We discuss the physical relevance of the metric considered and our restriction to first-quantized theory.
Pregnancy outcome following frozen embryo transfer after artificial cycle or treatment by clomiphene citrate

Abstract The optimal method to prepare endometrium before frozen embryo transfer (FET) is not yet established. We retrospectively studied 4496 FET and detailed pregnancy and miscarriage rates in three groups of patients according to the endometrium preparation they have followed before their successive FET: clomifene citrate (CC, group 1), artificial cycle (AC, group 2) or switch between CC and AC (group 3). The overall pregnancy rates per transfer were 24.3, 20.8 and 17.3% while the miscarriage rates reached 23.2, 29.8 and 42.5%, respectively. Group 1 experienced the highest ongoing pregnancy rate (18.6%), the lowest being observed in group 3 (10.0%, p < 0.001). Here we propose several alternatives to improve our AC protocol (group 2) that seemed less effective than CC (group 1) and we consider the use of a gonadotrophin-stimulated treatment for patients with the lowest reproductive outcomes (group 3).
Inhibition of Endoplasmic Reticulum-Resident Glucosidases Impairs Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63 Spike Protein-Mediated Entry by Altering the Glycan Processing of Angiotensin I-Converting Enzyme 2

ABSTRACT Endoplasmic reticulum (ER)-resident glucosidases I and II sequentially trim the three terminal glucose moieties on the N-linked glycans attached to nascent glycoproteins. These reactions are the first steps of N-linked glycan processing and are essential for proper folding and function of many glycoproteins. Because most of the viral envelope glycoproteins contain N-linked glycans, inhibition of ER glucosidases with derivatives of 1-deoxynojirimycin, i.e., iminosugars, efficiently disrupts the morphogenesis of a broad spectrum of enveloped viruses. However, like viral envelope proteins, the cellular receptors of many viruses are also glycoproteins. It is therefore possible that inhibition of ER glucosidases not only compromises virion production but also disrupts expression and function of viral receptors and thus inhibits virus entry into host cells. Indeed, we demonstrate here that iminosugar treatment altered the N-linked glycan structure of angiotensin I-converting enzyme 2 (ACE2), which did not affect its expression on the cell surface or its binding of the severe acute respiratory syndrome coronavirus (SARS-CoV) spike glycoprotein. However, alteration of N-linked glycans of ACE2 impaired its ability to support the transduction of SARS-CoV and human coronavirus NL63 (HCoV-NL63) spike glycoprotein-pseudotyped lentiviral particles by disruption of the viral envelope protein-triggered membrane fusion. Hence, in addition to reducing the production of infectious virions, inhibition of ER glucosidases also impairs the entry of selected viruses via a post-receptor-binding mechanism.