Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Antenatal Care On Fetal, Neonatal And Maternal Outcomes: A Retrospective Cohort Study

This retrospective cohort study was conducted in the department of Obstetrics and Gynecology at King Abdulaziz Medical City, Saudi Arabia, between 2011 and 2013. Four hundred mothers were divided into two groups, whereas Group 1 had antenatal booking and group 2 didn’t. Participants were classified based on their antenatal risks into high, intermediate or low risk. The chi-squared test or Fisher exact test was used to compare differences in categorical variables.
Clinical efficacy & safety of oral Polypodium leucotomos extract for photoprotection: A systematic review

Background: Polypodium leucotomos extract (PLE) is a naturally derived compound from a fern native to South America. PLE has been shown to have antioxidant and photoprotective properties. Several different preparations of PLE are commercially available.Objective: To review the efficacy and safety of PLE for photoprotection in humans.Methods: A systematic review was conducted in 3 databases (Medline, Embase, and Cochrane) for studies that reported on the clinical efficacy and safety of PLE in humans. A data collection form was created for collecting study variables and risk of bias was assessed.Results: Eighteen studies with sample sizes ranging from n=5 to n-61 were included. The most common formulation of PLE studied was Fernblock® (Heliocare, Ferndale Healthcare, Ferndale, MI) in 18 studies. Most studies reported beneficial photoprotective effects of PLE as evidenced by increased MED. No serious adverse effects were reported.Conclusions: Multiple studies have shown the beneficial photoprotective effects and safety of the Fernblock® PLE formulation, but there is minimal evidence to support the safety and efficacy of other formulations. Given that the extraction methodology varies for herbal nutraceuticals and can affect its efficacy, these findings cannot be extrapolated to other formulations of PLE.
Differences in Clinical Evaluation of Dialyzed Patients with or Without Congestive Heart Failure

Objectives. To look for clinical and laboratory parameters which might be different in dialysis patients with con− gestive heart failure (CHF) from those without CHF. Material and Methods. The CHF group (NYHA I–III) included 13 patients (mean ± SD age: 63.9 ± 13.5 years, medi− an dialysis vintage: 15.2, range: 7.0–59.6 months). The group without CHF consisted of 17 persons (age: 50.3 ± 18.7 years, dialysis vintage: 24.7, range: 6.3–45.5 months). Clinical and laboratory parameters were compared in both groups. Results. The CHF patients were older (p = 0.035) and had higher white blood cell counts (8.05±1.87 vs. 6.50 ± 1.89 × 109/l, p = 0.034), serum glucose (141 ± 61 vs. 95.1 ± 14.6 mg/dl, p = 0.022), total body mass (TBM: 77.7 ± 13.8 vs. 68.0 ± 8.8 kg, p = 0.035), body mass index (BMI: 29.5 ± 8.2 vs. 24.5 ± 3.1 kg/m2, p = 0.035), and extracellular water (ECW) as the percentage of total body water (TBW) (46.5 ± 5.9 vs. 42.7 ± 2.8, p = 0.026). Serum albumin was lower in the CHF patients (3.38 ± 0.44 vs. 3.69 ± 0.45 g/dl, p = 0.045) and negatively correlated with ECW in all patients (r = –0.485, p = 0.007). After adjustment for gender and age, only differences in serum glucose, TBM, and BMI remained significant. There were no significant differences in the other examined parameters. Conclusions. CHF in dialysis patients is associated with advanced age, glucose intolerance/diabetes, and over− weight/obesity. Severity of uremic toxicity, hyperlidemia, hyperparathyroidism, inflammation, hypertension, and cig− arette smoking may not be more evident in this group than in that without CHF (Adv Clin Exp Med 2008, 17, 1, 5–14).
Respuesta agregativa de adultos de Coleomegilla maculata a la densidad y distribución de los huevos del cogollero de maíz

Aggregative response of Coleomegilla maculata (Coleoptera: Coccinellidae) adults to density and distribution of eggs of the fall armyworm. The attraction and predation of adults of Coleomegilla maculata De Geer to density and distribution of eggs of the fall armyworm, Spodoptera frugiperda (J. E. Smith) in corn plants, was studied in Beltsville, Maryland, U.S.A. Field and laboratory 2 x 2 factorials were conducted as completely randomized blocks, replicated five times. Two levels of egg density, 100 and 500 eggs, and two levels of egg distribution on corn plants were used. One and six hours after the experiment was initiated in the field, plants with high density of eggs distributed on ten masses, showed three times more adults of C. maculata than plants with high density concentrated in one egg mass. This pattern changed with egg low density, where more adults of the predator were observed on plants with eggs concentrated in one mass. Three times as many adults of the predator were observed on plants with high density egg masses than on plants with low density egg masses. Egg consumption by this predator was different with the densities studied; however, this pattern changed with prey distribution. Eggs consummed on plants with 100 and 500 eggs concentrated on a single mass were 50 and 100 eggs compared to 60 and 250 eggs on plants offering ten randomly distributed egg mass of each density in field studies. Similar results were obtained in laboratory studies where consumption was 80 and 50 eggs, and 70 and 230 eggs for plants with eggs concentrated in one mass of 100 and 500 eggs each and plants with ten randomly distributed egg masses of each density, respectively.
Trends in Low-Calorie Sweetener Consumption Among Pregnant Women in the United States

ABSTRACT Background Minimizing consumption of added sugars is recommended to prevent excessive weight gain among pregnant women. A common approach to lowering sugar intake is the use of low-calorie sweeteners (LCSs), yet little is known about LCS use during pregnancy or its effects on infant weight and health. Objective The aim of the study was to investigate temporal trends in LCS consumption by source (foods, beverages, or packets) among pregnant women in the United States from 1999 to 2014 and to compare recent LCS consumption patterns across sociodemographic subgroups and product categories. Methods Data were collected from pregnant women aged 20–39 y (n = 1,265) who participated in the NHANES from 1999–2000 through 2013–2014. Prevalence of LCS consumption was assessed using two 24-h dietary recalls. Analytical procedures for complex survey design were used, and sampling weights were applied to estimate national prevalence of LCS use. Rao–Scott modified chi-square tests were used to compare consumption prevalence across sociodemographic subgroups, and logistic regression was used to examine trends in LCS use over time. Results The prevalence of LCS consumption among pregnant women increased by approximately 50% rising from 16.2% in 1999–2004 to 24.0% in 2007–2014, P = 0.04, with the highest prevalence observed in 2005–2006 (38.4%). This trend was driven predominantly by increases in LCS beverage use (9.9% in 1999–2004 compared with 18.3% in 2007–2014, P = 0.02). Prevalence of LCS consumption was highest among non-Hispanic white women and increased with education and income. No differences were observed based on prepregnancy weight status or trimester of pregnancy. Conclusions Approximately one-quarter of pregnant women in the United States reported consumption of LCS during at least 1 of 2 dietary recalls. Given the widespread LCS consumption during pregnancy, research to elucidate potential effects of early life LCS exposure on taste preferences, weight trajectory, and risk of later metabolic disease is needed.
Health Benefits of Physical Exercise as a Lifestyle Habit in Asian Men and Women

• Page 1 of 9 • Citation: Goh VHH (2018) Health Benefits of Physical Exercise as a Lifestyle Habit in Asian Men and Women. Int Arch Public Health Community Med 2:011 Accepted: September 29, 2018; Published: October 01, 2018 Copyright: © 2018 Goh VHH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Error analysis for satellite gravity field determination based on two-dimensional Fourier methods

 The time-wise and space-wise approaches are generally applied to data processing and error analysis for satellite gravimetry missions. But both the approaches, which are based on least-squares collocation, address the whole effect of measurement errors and estimate the resolution of gravity field models mainly from a numerical point of indirect view. Moreover, requirement for higher accuracy and resolution gravity field models could make the computation more difficult, and serious numerical instabilities arise. In order to overcome the problems, this study focuses on constructing a direct relationship between power spectral density of the satellite gravimetry measurements and coefficients of the Earth's gravity potential. Based on two-dimensional Fourier transform, the relationship is analytically concluded. By taking advantage of the analytical expression, it is efficient and distinct for parameter estimation and error analysis of missions. From the relationship and the simulations, it is analytically confirmed that the low-frequency noise affects the gravity field recovery in all degrees for the instance of satellite gradiometer recovery mission. Furthermore, some other results and suggestions are also described. Correspondence to: Zebing Zhou
Angiotensin-Converting Enzyme Inhibitor Ramiprilat Interferes With the Sequestration of the B2 Kinin Receptor Within the Plasma Membrane of Native Endothelial Cells

Background—ACE (kininase II) inhibitors have been shown to exert their beneficial cardiovascular effects via the inhibition of both angiotensin II formation and bradykinin breakdown. Because recent evidence suggests that ACE inhibitors may also interfere with B2 kinin receptor signaling and thus enhance the vascular response to bradykinin, we examined whether the distribution of B2 kinin receptors within the plasma membrane of native endothelial cells is affected by an ACE inhibitor. Methods and Results—Localization of the B2 kinin receptor in membranes prepared from native porcine aortic endothelial cells was evaluated by means of specific [3H]bradykinin binding and immunoprecipitation of the B2 receptor from isolated membranes. Effects of bradykinin and ramiprilat on intracellular signaling were determined by monitoring the activation of the extracellularly regulated kinases Erk1 and Erk2 as well as [Ca2+]i increases in fura 2–loaded endothelial cells. Stimulation of native endothelial cells with bradyk.
Meeting report: Advances in minimal residual disease testing in multiple myeloma 2018

This report summarizes the 5th annual symposium on minimal residual disease (MRD) testing in multiple myeloma gathered experts from academia, industry and the FDA in New York City on 14 September 2018. Three recommendations were made: (a) MRD testing should be performed in patients who achieve a very good partial response (VGPR) in addition to complete response (CR); (b) MRD negativity at one tumor cell in 1 000 000 bone marrow cells (10−6) should be considered as a response category alongside the current definition of MRD negativity at 10−5; and (c) clinical trials reports should specify the sensitivity of MRD testing as well as the applied threshold for MRD negativity (ie, 10−5 or 10−6), and if possible report outcome data for both MRD thresholds. Overall, as discussed at the meeting, there is already solid evidence that bone marrow based MRD assessment is one of the strongest prognostic factors in multiple myeloma, and deeper responses correlate with increasingly favorable outcomes. Indeed, achieving MRD negativity appears to be more important than what treatment was used to get there. Going forward, there is a need for clinical trials focusing on MRD‐directed therapy to determine the role of MRD testing in everyday clinical decision‐making. Standardization of MRD testing and harmonization across centers will make it easier to learn from common experiences. Ongoing efforts are anticipated to establish MRD status as a regulatory endpoint for accelerated drug approval in multiple myeloma in the near future.
Detection of distributed denial of service attacks at source

From year to year new records of the amount of traffic in an attack are established, which demonstrate not only the constant presence of distributed denialof-service attacks, but also its evolution, demarcating itself from the other network threats. The increasing importance of resource availability alongside the security debate on network devices and infrastructures is continuous, given the preponderant role in both the home and corporate domains. In the face of the constant threat, the latest network security systems have been applying pattern recognition techniques to infer, detect, and react more quickly and assertively. This dissertation proposes methodologies to infer network activities patterns, based on their traffic: follows a behavior previously defined as normal, or if there are deviations that raise suspicions about the normality of the action in the network. It seems that the future of network defense systems continues in this direction, not only by increasing amount of traffic, but also by the diversity of actions, services and entities that reflect different patterns, thus contributing to the detection of anomalous activities on the network. The methodologies propose the collection of metadata, up to the transport layer of the osi model, which will then be processed by the machien learning algorithms in order to classify the underlying action. Intending to contribute beyond denial-of-service attacks and the network domain, the methodologies were described in a generic way, in order to be applied in other scenarios of greater or less complexity. The third chapter presents a proof of concept with attack vectors that marked the history and a few evaluation metrics that allows to compare the different classifiers as to their success rate, given the various activities in the network and inherent dynamics. The various tests show flexibility, speed and accuracy of the various classification algorithms, setting the bar between 90 and 99 percent.
Effect of Aging on Glycemic Status during Pregnancy

Background: Pregnancy is associated with profound alteration in maternal metabolism. But this altered glucose homeostasis during pregnancy causes significant increase in feto-maternal abnormalities. This risk may increase due to maternal ageing.Objective: To assess the effect of ageing during pregnancy on fasting and postprandial glucose and glycated hemoglobin level in order to find out the risk of gestational diabetes.Methods: This cross sectional study was carried out in the department of Physiology, Rajshahi medical college, between the periods of January 2010 to December 2010. Three hundred pregnant woman aged 15 to 39 years were enrolled in the study and were divided into 5 different age groups, fasting and postprandial blood glucose and glycated hemoglobin levels were estimated by standard laboratory procedure. Data were analyzed by using SPSS computer software program and the test for significance was done by Chi-square test.Result: About 43% of pregnant women belonging to age group 35-39 years were detected as gestational diabetes mellitus, whereas less than 1% pregnant women among 20-24 years age group was detected as GDM. Blood sugar level both FBS and PPBS of all the pregnant women of age group 15-19 years are within normal limit.Conclusion: Results of the study indicates that the incidence of GDM was proportionate to increasing maternal age. So close monitoring of older pregnant women should be done to avoid feto-maternal complications.TAJ 2017; 30(2): 60-64
Bone Marrow–Derived Cells Contribute to Vascular Inflammation but Do Not Differentiate Into Smooth Muscle Cell Lineages

Background—It has been proposed that bone marrow–derived cells infiltrate the neointima, where they differentiate into smooth muscle (SM) cells; however, technical limitations have hindered clear identification of the lineages of bone marrow–derived “SM cell–like” cells. Methods and Results—Using a specific antibody against the definitive SM cell lineage marker SM myosin heavy chain (SM-MHC) and mouse lines in which reporter genes were driven by regulatory programs for either SM-MHC or SM α-actin, we demonstrated that although some bone marrow–derived cells express SM α-actin in the wire injury–induced neointima, those cells did not express SM-MHC, even 30 weeks after injury. Likewise, no SM-MHC+ bone marrow–derived cells were found in vascular lesions in apolipoprotein E−/−mice or in a heart transplantation vasculopathy model. Instead, the majority of bone marrow–derived SM α-actin+ cells were also CD115+CD11b+F4/80+Ly-6C+, which is the surface phenotype of inflammatory monocytes. Moreover, adoptively tr.
Multivariate genetic divergence among sugarcane clones by multivariate analysis associated with mixed models

Este trabalho teve como objetivo avaliar a divergencia genetica em clones da cana-de-acucar usando a metodologia de dispersao grafica por componentes principais associada aos modelos lineares mistos, identificando quais os genotipos mais divergentes e os mais produtivos de forma mais precisa, para posterior combinacao. Foram avaliados 138 clones de cana-de-acucar da Serie RB97 do Programa de Melhoramento Genetico de Cana-de-Acucar da Universidade Federal do Parana, mais duas variedades padroes, em tres ambientes, com duas repeticoes. Os dois primeiros componentes explicaram 96% da variacao total, sendo suficientes para explicar a divergencia encontrada. A caracteristica que mais contribuiu para a divergencia genetica foi quilograma de brix por parcela (KBP), seguida por brix, massa de 10 colmos (M10) e numero de colmos por parcela (NCP). Os clones mais divergentes foram RB975008, RB975112, RB975019, RB975153 e RB975067 e os clones mais produtivos foram RB975269, RB977533, RB975102, RB975317 e RB975038.
Adaptive Positioning Systems Based on Multiple Wireless Interfaces for Industrial IoT in Harsh Manufacturing Environments

As the industrial sector is becoming ever more flexible in order to improve productivity, legacy interfaces for industrial applications must evolve to enhance efficiency and must adapt to achieve higher elasticity and reliability in harsh manufacturing environments. The localization of machines, sensors and workers inside the industrial premises is one of such interfaces used by many applications. Current localization-based systems are unable to deal with highly variable conditions, meaning that the solutions working well in stationary systems suffer from considerable difficulties in harsh environments, such as factories. As a result, the precision of localization techniques is not satisfactory in most industrial applications. This paper fills in the existing gap between static approaches and dynamic indoor positioning systems, by presenting a solution adapting the system to highly changeable conditions. The proposed solution makes use of a Machine Learning-based feedback loop that learns the variability of the environment. This feedback makes continuous fingerprint calibration feasible even in the presence of different machines and Industrial Internet of Things sensors that introduce variations to the electromagnetic environment. This paper also presents a comprehensive indoor positioning system solution that reduces complexity of hardware, meaning that a multi-standard-transceiver infrastructure may be adopted with reduced capital and operational expenditures. We have developed the system from scratch and have conducted an extensive range of testbed experiments showing that the multi-technology transceiver feature is capable of increasing positioning accuracy, as well as of introducing permanent fingerprints calibration at harsh industrial premises.
Real-time Online Probabilistic Medical Computation using Bayesian Networks

Advances in both computing power and novel Bayesian inference algorithms have enabled Bayesian Networks (BN) to be applied for decision-support in healthcare and other domains. This work presents CardiPro, a flexible, online application for interfacing with non-trivial causal BN models. Designed specifically to make BN use easy for less-technical users like patients and clinicians, CardiPro provides near real-time probabilistic computation. CardiPro was developed as part of the PamBayesian research project (www.pambayesian.org) and represents the first of a new generation of online BN-based applications that may benefit adoption of AI-based clinical decision-support.
The role of CC-chemokine receptor-like 2 in the B cell response

CCRL2 is a member of the atypical chemattractant family. It has been proposed to bind the chemokines CCL19 and CCL5, as well as the adipokine chemerin. Unlike typical chemokine receptors, atypical chemoattractant receptors do not undergo conventional G protein signalling upon binding, but instead degrade, transcytose or present their ligands on the cell surface. This study aims to characterise the role of CCRL2 in B cells upon their activation and differentiation into either extrafollicular plasmablasts or germinal centre B cells. CCRL2 mRNA is upregulated upon plasmablast differentiation. Upon immunisation with NP-Ficoll, CCRL2 deficient mice produce more NP-specific antibody and larger numbers of NP-specific plasmablasts. Further assessment show this phenotype is due to B cell intrinsic effects. CCRL2 deficient plasmablasts tend to proliferate more and undergo less apoptosis than CCRL2 expressing plasmablasts. The role of CCRL2 in the germinal centre was also assessed. Germinal centres formed normally, including polarisation into light and dark zones in CCRL2 deficient mice. However, FDCs within the germinal centre appeared to extend further into the follicular mantle in CCRL2 deficient mice. This may be the cause of an increased proportion of germinal centres over the whole spleen in CCRL2 deficient mice. These differences did not result in significant changes in affinity maturation. Together, this shows a novel role for CCRL2 in the regulation of the extrafollicular plasmablast response to NP-Ficoll. However, minor differences in CCRL2 deficient germinal centres do not affect high affinity plasma cell output, suggesting a minimal role of CCRL2 in GC function.