Miracle-dz/UniFAR-FTUs huggingface dataset:
Enseñar E/LE a la primera generación de nativos digitales

Resumen: Este articulo trata de la primera generacion de verdaderos nativos digitales en Europa, nacidos en torno al ano 2000 y que en la actualidad asisten a los institutos de secundaria. Son diferentes a los de generaciones anteriores debido sobre todo al impacto que la tecnologia ha tenido en sus vidas, pero la mayoria sigue sistemas educativos desfasados, disenados para alumnos del siglo pasado. Muchos profesores intentan adaptarse a la nueva situacion incorporando las TIC en sus cursos. La autora analiza el proceso de creacion de un telediario, actividad realizada en el marco de un proyecto piloto de uso de los Ipad en los cursos de E/LE. Este proyecto obtuvo el Primer Premio del concurso a la Mejor practica docente de E/LE basada en las TIC convocado por la Editorial Difusion/Prolinter en 2017, con la colaboracion del Instituto Cervantes y el patrocinio de SIELE y FEDELE. Palabras clave : E/LE con Ipads, nativos digitales, enfoque por proyectos, tarea final. Abstract : This article concerns the first generation of true digital natives in Europe, children born in 2000, who, today, attend colleges or secondary schools. They are different to the previous generations due to the important impact of technology on their lives. However, they are compelled to attend schools with an outdated educational system designed for the older generations. Some teachers try to adapt themselves to the new situation by incorporating the ICT. The Spanish teacher at the LFZ therefore analyzes in this article the elaboration process of a newscast, whilst using the school iPads with her students of second year of Spanish. This video was presented at a well-known contest amongst language teachers, where the best teaching practice of Spanish as a foreign language based on the use of ICT is selected, and won the first prize in March 2017. Keywords: S/FL, digital natives, S/FL with Ipads, Task-based language learning.
Very early-onset psychosis/schizophrenia: Case studies of spectrum of presentation and management issues

Schizophrenia occurs very uncommonly in children younger than 13 years. The disease is preceded by premorbid difficulties, familial vulnerability, and a prodromal phase. The occurrence of positive psychotic symptoms such as delusions and hallucinations depends on the level of cognitive development of child. Furthermore, at times it is very difficult to differentiate the psychopathology and sustain a diagnosis of schizophrenia in view of similarities with disorders such as autism, mood disorders, and obsessive compulsive disorders. Here, we present three case studies with varying presentation of childhood-onset psychosis/schizophrenia and associated management issues.
Design, Implementation and Validation of a GNSS Measurement Exclusion and Weighting Function with a Dual Polarized Antenna †

Global Navigation Satellite Systems (GNSSs) have become a ubiquitous tool for our modern society to carry out vital tasks such as transportation, civil engineering or precision agriculture. This breath has reached the realm of safety-critical applications such as time management of critical infrastructures or autonomous vehicles, in which GNSS is an essential tool nowadays. Unfortunately, current GNSS performance is not enough to fulfill the requirements of these professional and critical applications. For this reason, the FANTASTIC project was launched to boost the adoption of these applications. The project was funded by the European GNSS agency (GSA) in order to enhance the robustness and accuracy of GNSS in harsh environments. This paper presents the part related to the development of a weighting and exclusion function with a dual circularly polarized antenna. The idea is to reduce the effects of multipath by weighting and/or excluding those measurements affected by multipath. The observables and other metrics obtained from a dual polarized antenna will be exploited to define an exclusion threshold and to provide the weights. Real-world experiments will show the improvement in the positioning solution, using all available constellations, obtained with the developed technique.
Cardiac remodelling and haemodynamic characteristics in primary mitral valve regurgitation

Objective To assess the association between cardiac morphology and function assessed with cardiac MRI (CMRI) and haemodynamics at rest and during exercise in patients with primary mitral regurgitation (MR). Methods In an observational study, subjects with significant primary MR (N = 46) with effective regurgitant orifice ≥ 0.30 cm2 and left ventricular (LV) ejection fraction > 60% were examined with right heart catheterisation during rest and exercise and CMRI at rest. End-diastolic pressure volume relationship (EDPVR) was assessed using a single beat method using pulmonary capillary wedge pressure (PCWP) and end-diastolic volume. Patients were divided according to normal PCWP at rest (> 12 mm Hg) and with exercise (> 28 mm Hg). Results: Resting regurgitant volume correlated positively with resting PCWP, (r = 0.42, p = 0.002). However, with exercise no association between PCWP and regurgitant volume was seen (r = 0.09, p = 0.55). At rest left atrial (LA) maximal, minimal and volume index at atrial contraction correlated positively with PCWP (r = 0.60; r = 0.55; r = 0.58, all p < 0.001); in contrast none of these correlated with exercise PCWP (all p > 0.2). EDPVR in patients with high PCWP at rest was shifted towards higher volumes for the same pressures. The opposite was seen for patients with high PCWP during exercise where estimated volumes were smaller for the same pressure than patients with normal exercise PCWP. Conclusion In patients with significant MR the degree of regurgitation and LA dilatation is associated with resting PCWP. However, with exercise this association disappears. Estimation of EDPVR suggests lower LV compliance in patients where PCWP is increased with exercise. Clinical trial registration URL: https://clinicaltrials.gov/ct2/show/NCT02961647? term=HEMI&rank=1. ID: NCT02961647
Association between CD14 rs2569190 C>T polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects

Introduction Previous epidemiological studies have suggested that CD14 rs2569190 C>T polymorphism plays an important role in ischemic stroke (IS) risk, but the results were inconsistent. Therefore, we conducted a meta-analysis to determine the association between CD14 rs2569190 C>T polymorphism and IS susceptibility. Methods Online databases were searched from inception up to July 1, 2018, for studies concerning CD14 rs2569190 C>T polymorphism and its association with IS susceptibility. ORs and corresponding 95% CIs were calculated in the genetic models of each polymorphism locus with Stata Version 14.0. Furthermore, heterogeneity, meta-regression, accumulative analyses, sensitivity analyses, and publication bias were examined. Results Overall, 10 observed studies involving 5,277 subjects were included in this meta-analysis on CD14 rs2569190 C>T polymorphism. Generally, no significant associations were found between CD14 rs2569190 C>T polymorphism and IS risk (allele contrast of T vs C: OR =1.03, 95% CI =0.96–1.12, P=0.41, I2=27.8%; co-dominant models of CT vs CC: OR =1.01, 95% CI =0.81–1.25, P=0.95, I2=51.9%; co-dominant models of TT vs CC: OR =1.04, 95% CI =0.89–1.22, P=0.62, I2=25.1%; dominant model of CT + TT vs CC: OR =1.02, 95% CI =0.84–1.25, P=0.82, I2=51.4%; recessive model of TT vs CC + CT: OR =1.07, 95% CI =0.95–1.22, P=0.28, I2=0%), similar to the results in the subgroup analysis. Conclusion The current evidence indicated that CD14 rs2569190 C>T polymorphism was not a critical risk factor for IS development.
Clinical, neurocognitive and demographic factors associated with functional impairment in the Australian Brain and Mind Youth Cohort Study (2008–2016)

Objectives We sought to determine the unique and shared contributions of clinical, neurocognitive and demographic factors to functional impairment in a large, transdiagnostic, clinical cohort of adolescents and young adults. Design Cross-sectional baseline data from a prospective, cohort study. Setting Help-seeking youth referred from outpatient services were recruited to the Brain and Mind Youth Cohort (2008–2016) in Sydney, Australia. Participants In total, 1003 outpatients were recruited, aged between 12 and 36 years (mean= 20.4 years, 54% female), with baseline diagnoses of affective, psychotic, developmental or behavioural disorders. Interventions Treatment as usual. Primary outcome measures Social and occupational functioning was used to index level of functional impairment. Structural equation modelling was used to examine associations between neurocognition, core clinical symptoms and alcohol and substance use, and clinician-rated and researcher-rated functional impairment. Moderator analyses were conducted to determine the potential influence of demographic and clinical factors (eg, medication exposure). Results Independent of diagnosis, we found that neurocognitive impairments, and depressive, anxiety and negative symptoms, were significantly associated with functioning. The association of neurocognition with social and occupational functioning remained significant even when constraining for age (15–25-year-olds only) or diagnosis (affective disorders only) in the final model. Conclusions This study demonstrated that, in a clinically representative sample of youth, the key determinants of functioning may not be disorder specific. Further, evidence of neurocognitive dysfunction suggests that interventions that target cognition and functioning should not necessarily be reserved just for older adults with established illness.
Effect of ranolazine on glycaemia in adults with and without diabetes: a meta-analysis of randomised controlled trials

Background Ranolazine is an antianginal drug reported to have hypoglycaemic effects. Objectives To assess the effect of ranolazine versus placebo on glycaemic control for adults with and without diabetes. Methods A systematic search of seven databases was conducted to identify all randomised controlled trials that compared the effect of ranolazine versus placebo on haemoglobin A1c (HbA1c) and/or fasting plasma glucose (FPG) and/or incidence of hypoglycaemia. We used mean differences in HbA1c and FPG to express intervention effect estimates and analysed the data with random-effects model for meta-analyses using Revman 5.3. Results We identified seven trials including 6543 subjects to assess the effect of ranolazine on HbA1c and/or FPG. A separate trial that included 944 subjects was included to assess the effect of ranolazine on hypoglycaemia. The change in HbA1c for all patients was −0.36% (95% CI −0.57% to −0.15%; p=0.0004, I2=78%). In patients with diabetes, the change in HbA1c was −0.41% (95% CI −0.58% to −0.25%; p<0.00001, I2=65%). There was no significant difference in FPG between ranolazine and placebo groups (−2.58 mmol/L, 95% CI −7.02 to 1.85; p=0.25; I2=49%) or incidence of hypoglycaemia between ranolazine and placebo groups (OR 1.70, 95% CI 0.89 to 3.26; p=0.61, I2=0%). Conclusions Our meta-analytic findings support the fact that ranolazine improves HbA1c without increasing the risk of hypoglycaemia. It therefore has a potential of having an additional benefit of improving glycaemic control in patients with chronic stable angina and diabetes.
Overexpression of lncRNA PTENP1 suppresses glioma cell proliferation and metastasis in vitro

Background Glioma is one of the most common malignancies of the central nervous system in adults. The lncRNA PTEN pseudogene-1 (PTENP1) has been reported to play an important role in the development and progression of various cancers. However, the molecular mechanism by which lncRNA PTENP1 affects the development and progression of gliomas remains unclear. Materials and methods The levels of PTENP1 expression in glioma tissues and normal brain tissues were detected by quantitative real-time PCR. Cell Counting Kit-8 and 5-ethynyl-2′-deoxyuridine staining assays were performed to detect cell proliferation. Flow cytometry was used to analyze cell cycle progression. Transwell assay and scratch test were used to detect cell migration and invasion, and Western blot studies were performed to detect protein expression. Results Our results showed that expression of lncRNA PTENP1 was decreased in glioma tissues when compared with normal brain tissues. Overexpression of PTENP1 suppressed SHG44 and U251 cell proliferation and significantly decreased the numbers of S-phase cells. Furthermore, the invasion and migration abilities of SHG44 and U251 cells were reduced after being transfected with a PTENP1 overexpression plasmid. Overexpression of PTENP1 induced the expression of p21 protein and suppressed the p38 signaling pathway. Conclusion Our study investigated the function of PTENP1 in glioma and provided new insights for treating that malignancy.
Liver segment imaging using monocyte sequestration: a potential tool for fluorescence-guided liver surgery

Background: The accurate determination of liver segment anatomy is essential to perform liver resection without complications and to ensure long-term outcomes after this operation. There are several perioperative methods for segment identification and surgical navigation, such as intraoperative ultrasound, indigo carmine and near-infrared imaging with indocyanine green. The present study experimentally analyzed the usefulness of monocyte sequestration for liver segment labeling and imaging. Methods: Human monocytes were isolated from peripheral blood and directly or indirectly labeled with calcein or IRDye 800CW. Potential toxicity, labeling stability, and adhesion to ICAM-1 were analyzed in vitro. Monocyte sequestration in the liver microvasculature and liver segment labeling and boundary demarcation were studied using isolated mouse and pig liver perfusion and via intraportal injection in mouse liver tumor models. Results: The highest monocyte labeling efficiency was achieved using direct labeling with IRDye 800CW. Labeling was stable and did not influence cell viability. The labeled monocytes were highly sequestrated in the liver microvasculature, both after ex vivo perfusion and after injection in vivo , resulting in excellent labeling of selected liver segments and strong segment boundary demarcation. In contrast to results to a normal liver, monocyte sequestration was very low in tumor-associated blood vessels. Conclusions: The present experimental study shows that sequestration of labeled monocytes after superselective application demarcates the selected liver segment. These results illustrate potential of this technique for surgical navigation during liver surgery.
Filaments of galaxies as a clue to the origin of ultrahigh-energy cosmic rays

Filaments of galaxies, connected to the Virgo Cluster, around the TA hotspot, may be a clue for the origin of hotspot UHECRs. Ultrahigh-energy cosmic rays (UHECRs) are known to come from outside of our Galaxy, but their origin still remains unknown. The Telescope Array (TA) experiment recently identified a hotspot, that is, a high concentration of anisotropic arrival directions of UHECRs with energies above 5.7 × 1019 eV. We report here the presence of filaments of galaxies, connected to the Virgo Cluster, in the sky around the hotspot and a statistically significant correlation between hotspot events and the filaments. With 5-year TA data, the maximum significance of binomial statistics for the correlation is estimated to be 6. 1σ at correlation angle 3.4°. The probability that the above significance appears by chance is ~2.0 × 10−8 (5.6σ). On the basis of this finding, we suggest a model for the origin of TA hotspot UHECRs; they are produced at sources in the Virgo Cluster, and escape to and propagate along filaments, before they are scattered toward us. This picture requires the filament magnetic fields of strength ≳ 20 nG, which need to be confirmed in future observations.
Body composition and physical activity as mediators in the relationship between socioeconomic status and blood pressure in young South African women: a structural equation model analysis

Objectives Varying hypertension prevalence across different socioeconomic strata within a population has been well reported. However, the causal factors and pathways across different settings are less clear, especially in sub-Saharan Africa. Therefore, this study aimed to compare blood pressure (BP) levels and investigate the extent to which socioeconomic status (SES) is associated with BP, in rural and urban South Africa women. Setting Rural and urban South Africa. Design Cross-sectional. Participants Cross-sectional data on SES, total moderate and vigorous physical activity (MVPA), anthropometric and BP were collected on rural (n=509) and urban (n=510) young black women (18–23 years age). Pregnant and mentally or physically disabled women were excluded from the study. Results The prevalence of combined overweight and obesity (46.5% vs 38.8%) and elevated BP (27.0% vs 9.3%) was higher in urban than rural women, respectively. Results from the structural equation modelling showed significant direct positive effects of body mass index (BMI) on systolic BP (SBP) in rural, urban and pooled datasets. Negative direct effects of SES on SBP and positive total effects of SES on SBP were observed in the rural and pooled datasets, respectively. In rural young women, SES had direct positive effects on BMI and was negatively associated with MVPA in urban and pooled analyses. BMI mediated the positive total effects association between SES and SBP in pooled analyses (ß 0.46; 95% CI 0.15 to 0.76). Conclusions Though South Africa is undergoing nutritional and epidemiological transitions, the prevalence of elevated BP still varies between rural and urban young women. The association between SES and SBP varies considerably in economically diverse populations with BMI being the most significant mediator. There is a need to tailor prevention strategies to take into account optimising BMI when designing strategies to reduce future risk of hypertension in young women.
Current Trends in the Consumption of Fats and Foods

One of the major changes in the way Americans have consumed foods over the past 30 years has been an appreciable increase in the number of meals eaten outside the home and in the total per capita calories ingested. Factors such as convenience, increase in the number of two-earner households, and higher incomes have contributed to this phenomenon (Stewart et al., 2004). The convenience of eating out and use of already prepared home meal replacements has also resulted in taking away control over what food ingredients will go into a meal, including types of fats, carbohydrates, and proteins. This trend appears to be being followed by the rest of the developed countries. Consumer spending continued to grow by 18% at full-service restaurants and by 6% for fast food in the 2000s. The total food expenditure away from the home amounted to US $641 billion in 2011, as opposed to $263 billion spent in 1992 (USDA-ERS, 2013a), with the average American household spending approximately 10% of its income on food and about 43% of the food dollar was spent on food away from the home. Fast-food restaurants, restaurant take-out, and supermarkets are playing an important role in the increased use of home meal replacements by American households. These foods are designed to be easy to eat, simple to prepare or reheat for consumption at home. It is estimated that eight out of ten meals eaten at home were not necessarily homemade. As previously mentioned, this convenience and novelty of products that eating out and home meal replacements brings to the consumer has also taken away control over what ingredients are being consumed, especially with regards to critical ingredients such as the fats that are used. The US consumer, on the other hand, is becoming increasingly aware of healthier food options, especially when it comes to fats and oils. For example, the consumer is starting to focus more on foods that are made with whole grains, are rich in fiber,
Renaissance Concepts of Shame and Pocaterra's Dialoghi Delia Vergogna

Persons of authority in early modern Europe—whether parents, preachers or princes—knew well that among the resources available to them for controlling behavior and maintaining hierarchies, there was always shame. Humankind, to its woe, had experienced shame in the Garden of Eden. Noah had been shamed by his nakedness, Sarah by her barrenness, Jacob by his effeminate body, Potiphar's wife through her brazen advances. Hesiod had introduced two sorts of shame: the right kind, derived from modesty; and the wrong kind, produced by poverty. These instances, and many others from ancient and medieval sources, lay at hand for easy use by Renaissance moralists, and who is not a moralist? Applying their own imaginative skills to techniques and rituals of humiliation, medieval and early modern people devised such innovations as the pitture infamanti, the dunce cap, the stocks, the charivari, the yellow badge.
Popular Microblogging Quality Prediction Model using Potential Fusion Characteristics

In this paper, we put forward a potential fusion feature model to deal with the popularity prediction problem for Sina Microblogging. We analyze the characteristics of microblog forwarding number, number of views and comments. By combining the implicit relation between features, we fuse the n-gram model to establish a quality prediction model for microblogging. The characteristics of the model are combined with the regression model to predict the popularity of a microblog text. Our experiment results show that the model is effective.
Making Chinese Cuisine Artistic: Fad or Trend?

The Chinese cuisine has been known for its variety of flavors, cooking methods, ingredients, etc., but its aesthetic pursuit is comparatively less manifested. However, recent years have seen fast development in this respect. For example, Da Dong Artistic Conception Chinese Cuisine, a gastronomy brand in China, boasts artistic presentation of Chinese cuisine. The presentation of many dishes in Da Dong resembles Chinese traditional paintings, paired with Chinese poems, enhancing its artistic conception, which has gone far beyond utilization of the visual effects. While the Chinese dining market is still pursuing standardization, the creation of Chinese cuisine with artistic conception at this time point has attracted much attention and debate. Therefore, this study tries to understand the rationales behind the creation of Da Dong Artistic Conception food from the restaurants’ perspectives, as well as the acceptance and perceptions of this type of cuisine from the eyes of the consumers.