Miracle-dz/UniFAR-FTUs huggingface dataset:
El papel del status léxico y de la frecuencia del estímulo-señal en la condición no relacionada con la técnica de presentación enmascarada del estímulo-señal

Se efectuo un experimento para analizar el papel del status lexico y la frecuencia de uso de los estimulos-senal no relacionados en la tecnica de presentacion enmascarada del estimulo-senal con la tarea de decision lexica. La asincronia estimular senal-test era de 66 ms. Hasta ahora, los diferentes estudios han empleado estimulos-senal no relacionados de la misma frecuencia que los estimulos-senal relacionados, con el supuesto de que podria haber un efecto de la frecuencia (o del status lexico) de los estimulos-senal no relacionados, pero sin efectuar estudios sistematicos sobre el tema. Los resultados del experimento muestran que los tiempos de reaccion para los estimulos-test (tanto palabras-test como pseudopalabrastest) no se ven modulados por el status lexico o la frecuencia de uso de los estimulos-senal no relacionados. Se analizan las implicaciones de tales resultados para futuros estudios con la tecnica de presentacion enmascarada del estimulo-senal.
An Indoor Planning Tool with Both Antennas Placement and Wiring Optimization

As the wireless communications systems become more and more popular, the subscribers want to use their phone in all the places they live. In these conditions, an indoor planning tool may be very useful for the operators to offer their subscribers the best coverage with the lowest costs. The indoor planning tool that is presented here is a combination of a prediction and an optimization tool. The prediction tool is based on a UTD (Uniform Theory of Diffraction) - Ray Launching. The optimization tool is based on both placement and wiring optimization. This is probably the main originality of this work as the question of the wiring between the BTS and the antennas is rarely studied although it is a very important one.
Interrelaciones entre hospedadores, vectores y parásitos sanguíneos en poblaciones de aves silvestres

El parasitismo es una de las relaciones simbioticas mas importantes en la naturaleza. Las aves, como la mayoria de los organismos silvestres, se encuentran con frecuencia afectadas por una enorme diversidad de parasitos, tanto endoparasitos como ectoparasitos. El estudio del parasitismo bajo un prisma ecologico-evolutivo es una de las principales vias de investigacion mundial en el campo de la biologia evolutiva por la importancia de estos organismos parasitos en la evolucion de sus hospedadores. Bajo este prisma, en este estudio, primero se investigo la diversidad de parasitos sanguineos que afectan a una poblacion silvestre de un pequeno ave forestal, el herrerillo comun Cyanistes caeruleus. Por otro lado, se investigo la ocurrencia de invasiones multiples de eritrocitos por parasitos del genero Haemoproteus, un parasito emparentado con los parasitos de la malaria. Este estudio permitio concluir que las invasiones multiples podrian ser un mecanismo mediado por el hospedador para reducir la transmision del parasito y los costes asociados a la infeccion o bien, un mecanismo azaroso debido a altas intensidades de infeccion. Por otro lado, se investigo la diversidad de insectos vectores de estos parasitos sanguineos que afectan a las aves silvestres, identificando los factores que determinan su abundancia en los nidales de diferentes especies de aves. Asi, se comprobo que factores bioticos, como el numero de polluelos presentes en el nido, o abioticos, como la temperatura ambiental o la velocidad del viento, son importantes determinantes afectando la abundancia de estos insectos en los nidales de las aves silvestres. Por ultimo, se investigo los efectos de estos parasitos en las aves, para ello, se medico un grupo de aves silvestres con un farmaco antimalarico reduciendo a carga de parasitos sanguineos. Este experimento puso de manifiesto que los parasitos son un importante factor determinando la supervivencia de las aves bajo condiciones naturales. En resumen, este estudio supone un avance en el conocimiento en los parasitos que afectan a las aves silvestres, los mecanismos que afectan a la transmision de estos parasitos y los efectos que tienen en sus hospedadores en condiciones naturales.
InteractiveROSETTA: a graphical user interface for the PyRosetta protein modeling suite

UNLABELLED Modern biotechnical research is becoming increasingly reliant on computational structural modeling programs to develop novel solutions to scientific questions. Rosetta is one such protein modeling suite that has already demonstrated wide applicability to a number of diverse research projects. Unfortunately, Rosetta is largely a command-line-driven software package which restricts its use among non-computational researchers. Some graphical interfaces for Rosetta exist, but typically are not as sophisticated as commercial software. Here, we present InteractiveROSETTA, a graphical interface for the PyRosetta framework that presents easy-to-use controls for several of the most widely used Rosetta protocols alongside a sophisticated selection system utilizing PyMOL as a visualizer. InteractiveROSETTA is also capable of interacting with remote Rosetta servers, facilitating sophisticated protocols that are not accessible in PyRosetta or which require greater computational resources. AVAILABILITY AND IMPLEMENTATION InteractiveROSETTA is freely available at https://github.com/schenc3/InteractiveROSETTA/releases and relies upon a separate download of PyRosetta which is available at http://www.pyrosetta. org after obtaining a license (free for academic use).
Windrush: The Irresistible Rise of Multi-Racial Britain

Broadcaster Trevor Phillips and his novelist brother Mike retell the very human story of Britain's first West Indian immigrants and their descendants from the first wave of immigration in 1948 to the present day. Windrush: The Irresistible Rise of Multi-Racial Britain opens with the memories and impressions of the survivors of the voyage of the Windrush, the troop ship which brought the first West Indian immigrants to Great Britain in 1948. Fifty years on, the migrants tell an epic tale of British life in the twentieth century, through the witness of their descendants, friends, neighbours and colleagues and the testimonies of politicians who made the key decisions alongside those who were then opposed to the presence of the black settlers. Windrush moves through the crucial events of British social history in the second half of the twentieth century: the great riots of the late fifties and early sixties, the hysteria of Powellism, the remodelling of England's inner cities and the current passionate debates about the meaning of Englishness. Concluding with a portrait of multi-racial Britain in the present day, Windrush is a celebration of the black British and of the new heritage Britain will carry forward into the twenty-first century.
Tentative de suicide et suicide, les tragédies de l'adolescence.

Pour certaines familles, l’autonomie est assimilee a une menace ; la tentative de suicide exprime la difficulte adaptative du systeme familial au moment du depart de l’un de ses membres. Le suicide, par contre, revele l’inaptitude et l’incapacite de la famille a evoluer et a s’adapter a l’ecosysteme environnant, dynamique et en constante mutation. L’autonomie equivaut a la mort.
Utility of the Germ Tube Test for Direct Identification of Candida albicans from Positive Blood Culture Bottles

ABSTRACT We compared the germ tube test for the direct identification of Candida albicans from positive blood culture bottles, with results obtained from subcultured colonies. The direct germ tube test was 87.1% sensitive and 100% specific for the identification of C. albicans when the results obtained from fungal colonies were compared.
Quantitative aspects of phosphorus absorption in ruminants

Phosphorus absorption in ruminants was analysed from a database described in a previous article. For common values of ingested phosphorus (2.5–5.0 g·kg –1 of DM), 0.73 of dietary phosphorus is absorbed. The remaining variability is probably due to phosphorus quality. Phosphorus absorbed from silage, cereal, cereal by-products and hay differs greatly. The current true absorption coefficient used to calculate daily phosphorus supply is a constant value in the current systems and often it underestimates the true absorption resulting in an excess of phosphorus being supplied in the diets. Adjusting the true absorption coefficient values requires better characterisation of the phosphorus supplied by each feedstuff. Dietary influences (phytate phosphorus, crude fibre, etc.) were investigated but trials assessing the ration effect on phosphorus absorption are lacking. Since rumen microbes have specific phosphorus requirements, particularly for cell-wall degradation, the feedstuff phosphorus availability for the rumen ecosystem is discussed. absorption / availability / phosphorus / quantitative aspect
Regression tree analysis of ecological momentary assessment data

ABSTRACT An increasingly popular form of data collection in health psychology research is Ecological Momentary Assessment (EMA); that is, using diaries or smartphones to collect intensive longitudinal data. This method is increasingly applied to the study of relationships between state-based aspects of individuals’ functioning and health outcomes (e.g., binge eating, alcohol use). Analysis of such data is challenging and regression tree modelling (RTM) may be a useful alternative to multilevel modelling for investigating the association between a set of explanatory variables and a continuous outcome. Furthermore, RTM outputs ‘decision trees’ that could be used by health practitioners to guide assessment and tailor intervention. In contrast to regression, RTM is able to easily accommodate many complex, higher-order interactions between predictor variables (without the need to create explicit interaction terms). These benefits make the technique useful for those interested in monitoring and intervening upon health and psychological outcomes (e.g., mood, eating behaviour, risky alcohol use, and treatment adherence). Using real data, this paper demonstrates both the benefits and limitations of RTM and how to extend these models to accommodate analysis of nested data; that is, data that arise from EMA where repeated observations are nested within individuals.
Measuring both procalcitonin and C-reactive protein for a diagnosis of sepsis in critically ill patients

Background The usefulness of procalcitonin (PCT) and C-reactive protein (CRP) as individual biomarkers, and in combination, for the identification of infections in a critically ill patient cohort was evaluated retrospectively. Methods Best cut-off values for PCT and CRP for a diagnosis of sepsis in critically ill patients were determined using receiver operator characteristic (ROC) curve analysis. Both combined tests and individual tests were performed for PCT and CRP, with positive and negative results recorded, and accuracy evaluated using odds ratios (OR). Results In the 55 critically ill patients studied, the best cut-off value for PCT for a diagnosis of sepsis was 1.1 ng/ml (sensitivity, specificity and negative predictive values [NPV] were 82%, 68% and 71%, respectively). In addition, the best cut-off value for CRP was 50.7 mg/l ( sensitivity, specificity and NPV of 90%, 68% and 83%, respectively). Measuring PCT and CRP in combination provided a sensitivity of 79%, a specificity of 86%, and a positive predictive value (PPV) of 90%. Diagnostic OR for the combination of biomarkers versus CRP alone (19 and 18, respectively) were greater than that for PCT (9). Conclusion For critically ill patients, CRP and CRP in combination with PCT were found to be suitable biomarkers for diagnosing sepsis, based on their NPV and PPV.
The Role of the Knee Brace in the Prevention of Anterior Knee Pain Syndrome

Our prospective study evaluates the use of a knee brace with a silicon patellar support ring as a method of preventing anterior knee pain from developing in young persons undergoing strenuous physical exercise. We studied 60 young athletes, who qualified for a strenu ous physical training course and who had not suffered from anterior knee pain previously. Twenty-seven sub jects were in the brace group and 33 were in the nonbrace control group. The incidence of anterior knee pain syndrome increased with the intensity of exertion as the study progressed; i.e., subjects ran 6 km in the 1 st week, gradually increasing each week up to 42 km/week at the 8th week. Yet, there was a significant reduction in the incidence of the syndrome at the end of the study in male athletes who had applied the braces before exercise sessions and in the brace group as a whole, compared with the control group. Prophylactic use of the brace, as described, did not reduce the ability of the athletes who wore braces to improve their physical fitness parameters in response to exercise. These data indicate that the use of a brace may be an effective way to prevent the development of anterior knee pain syndromes in persons participating in strenuous and intensive physical exercise.
Histologic Grading of Prostatic Adenocarcinoma Can Be Further Optimized: Analysis of the Relative Prognostic Strength of Individual Architectural Patterns in 1275 Patients From the Canary Retrospective Cohort

Histologic grading remains the gold standard for prognosis in prostate cancer, and assessment of Gleason score plays a critical role in active surveillance management. We sought to optimize the prognostic stratification of grading and developed a method of recording and studying individual architectural patterns by light microscopic evaluation that is independent of standard Gleason grade. Some of the evaluated patterns are not assessed by current Gleason grading (eg, reactive stromal response). Individual histologic patterns were correlated with recurrence-free survival in a retrospective postradical prostatectomy cohort of 1275 patients represented by the highest-grade foci of carcinoma in tissue microarrays. In univariable analysis, fibromucinous rupture with varied epithelial complexity had a significantly lower relative risk of recurrence-free survival in cases graded as 3+4=7. Cases having focal “poorly formed glands,” which could be designated as pattern 3+4=7, had lower risk than cribriform patterns with either small cribriform glands or expansile cribriform growth. In separate multivariable Cox proportional hazard analyses of both Gleason score 3+3=6 and 3+4=7 carcinomas, reactive stromal patterns were associated with worse recurrence-free survival. Decision tree models demonstrate potential regrouping of architectural patterns into categories with similar risk. In summary, we argue that Gleason score assignment by current consensus guidelines are not entirely optimized for clinical use, including active surveillance. Our data suggest that focal poorly formed gland and cribriform patterns, currently classified as Gleason pattern 4, should be in separate prognostic groups, as the latter is associated with worse outcome. Patterns with extravasated mucin are likely overgraded in a subset of cases with more complex epithelial bridges, whereas stromogenic cancers have a worse outcome than conveyed by Gleason grade alone. These findings serve as a foundation to facilitate optimization of histologic grading and strongly support incorporating reactive stroma into routine assessment.
Intraspecific divergence and evolution of a life‐history trade‐off along a successional gradient in Hawaii's Metrosideros polymorpha

The importance of environmental gradients in the diversification of long‐lived tree species is poorly understood. Two morphologically distinct varieties of the endemic Hawaiian tree, 'ōhi'a lehua (Metrosideros polymorpha), are the canopy dominants at alternate extremes of a successional gradient formed by the recurring disturbance of lava flows on east Hawai'i Island. The maintenance of these varieties despite hybridization may be due to disruptive selection at either end of the successional gradient. To test this hypothesis, seeds from three, replicate monotypic stands of each variety on east Hawai'i Island were germinated and the resulting seedlings grown under four combinations of light and nitrogen levels in a greenhouse, and at early‐ and late‐successional field sites. Growth and survivorship measures revealed differential fitness of these varieties in high‐ and low‐light environments in the greenhouse with corresponding differential fitness in early‐ and late‐successional field sites. Unique light‐by‐nitrogen interaction effects on growth were observed in each variety, and only the late‐successional variety appeared to be nitrogen limited. These two varieties exhibit the classic plant life‐history trade‐off between fast growth in high light and high survivorship in shade, but notably within a single tree species. These findings strongly implicate a role for Hawaii's striking environmental heterogeneity in the emergence of at least two endemic forms of this woody genus.
Interrelations between Sympathoadrenal System andHypothalamo‐Pituitary‐Adrenocortical/Thyroid Systemsin Rats Exposed to Cold Stress

The interrelations between sympathoadrenal (SA) system and hypothalamo‐pituitary‐adrenocortical (HPA) or hypothalamo‐pituitary‐thyroid (HPT) system during cold stress were examined by measuring plasma levels of dihydroxyphenylalanine (DOPA), catecholamine and their metabolites in adrenalectomized (ADX) and thyroidectomized (TX) rats exposed to cold stress (−3 °C). Plasma levels of adrenocorticotropic hormone (ACTH), corticosterone (CORT), thyroid‐stimulating hormone (TSH) and thyroid hormones in cold‐stressed rats were measured also. Plasma ACTH levels were increased transiently after 1 h of cold exposure, after which the circadian rhythm and plasma levels of ACTH were similar to those of normal rats. Plasma CORT levels were also elevated after 1 h of cold exposure; the increased levels of CORT tended to return to normal levels after 9 h of cold, but remained higher than those of normal rats during at least 24 h of cold exposure. Plasma ACTH levels of 5 day cold‐stressed rats were no longer elevated above those of control rats and plasma CORT levels were only slightly higher than in control animals. However, plasma levels of TSH and free thyroid hormones were elevated after 1 day and remained elevated after 5 days of cold exposure. Thus, cold stress appears to activate chronically the HPT system, but only transiently activates the HPA system. ADX rats had higher basal plasma levels of dihydroxyphenylglycol (DHPG), methoxyhydroxyphenylglycol (MHPG), DOPA and homovanillic acid (HVA) than those of sham‐operated (SHAM) rats, but norepinephrine (NE) levels were not significantly greater than in SHAM animals. TX rats had higher basal plasma levels of NE, epinephrine (EPI) and dopamine (DA), as well as much higher plasma levels of the metabolites. Exposure to cold increased plasma NE levels in both ADX and TX rats, but the increments in TX rats were much greater than in SHAM and ADX groups. Plasma EPI levels were not significantly elevated during cold exposure in SHAM rats, but were highly elevated in TX rats exposed to cold. TX rats had much larger increments in plasma levels of DHPG, MHPG, DA, dihydroxyphenylacetic acid (DOPAC) and HVA during cold exposure than those of SHAM and ADX rats. These results are consistent with the view that endogenous glucocorticoids restrain responses of catecholamine synthesis, release, reuptake, and metabolism in sympathetic nervous system of cold‐stressed animals, but that in the absence of an effective HPT system, there is enhanced sympathoadrenal medullary function and augmentation of their responses to cold as a means for maintaining body temperature when the HPT thermogenesis system is impaired.
Integrating Lesbian, Gay, Bisexual, and Transgender (LGBT) Content Into Undergraduate Medical School Curricula: A Qualitative Study.

BACKGROUND The lesbian, gay, bisexual, and transgender (LGBT) community is a diverse, underserved, and often stigmatized group that faces many barriers to accessing quality healthcare. Not only are few practicing physicians knowledgeable about and sensitive to the needs of LGBT patients, but medical school curricula include limited LGBT-related content. Our goals were to use LGBT-related educational sessions to gauge undergraduate medical students' interest and their perceptions of relevance and to eventually incorporate this topic into the curriculum. METHODS We provided 4 educational sessions to preclinical medical students at the Tulane University School of Medicine: 3 optional, 1-hour didactic sessions and 1 standardized patient encounter. Following sessions 1-3, students completed electronic feedback forms; we then analyzed their responses thematically. RESULTS THE THEMATIC ANALYSIS OF STUDENT RESPONSES IDENTIFIED KEY THEMES: a current lack of exposure to LGBT content, agreement that LGBT material is applicable to students' work as future physicians, and the relevance of including such information in the medical school curriculum. CONCLUSION The study validated the underlying assumption that LGBT educational sessions are meaningful to and valued by medical students.
The antioxidant activity of a triterpenoid glycoside isolated from the berries of Hedera colchica: 3‐O‐(β‐d‐glucopyranosyl)‐hederagenin

The antioxidant activity of a triterpenoid glycoside [3‐O‐(β‐D‐glucopyranosyl)‐hederagenin; OGH] isolated from the berries of Hedera colchica, an ivy species endemic in Georgia, was investigated. The antioxidant properties of OGH were evaluated using different antioxidant assays: 1,1‐diphenyl‐2‐picryl‐hydrazyl free radical (DPPH·) scavenging, total antioxidant activity, reducing power, superoxide anion radical (O2·−) scavenging, hydrogen peroxide (H2O2) scavenging and metal chelating activities. The total antioxidant activity was measured according to the ferric thiocyanate method. α‐Tocopherol and trolox, a water‐soluble analogue of tocopherol, were used as reference antioxidant compounds. At a 30 µg/mL concentration, the inhibitory effects of OGH on the peroxidation of linoleic acid emulsion was found to be 95.3%, whereas α‐tocopherol and trolox exhibited 88.8% and 86.2% inhibition of peroxidation in the system, respectively. In addition, OGH had effective DPPH· scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, total reducing power and metal chelation of ferrous ions activities. These various antioxidant activities were compared with α‐tocopherol and trolox. Copyright © 2006 John Wiley & Sons, Ltd.