Miracle-dz/UniFAR-FTUs huggingface dataset:
Rodent Model of Muscular Atrophy for Sarcopenia Study

The hallmark symptom of sarcopenia is the loss of muscle mass and strength without the loss of overall body weight. Sarcopenia patients are likely to have worse clinical outcomes and higher mortality than do healthy individuals. The sarcopenia population shows an annual increase of ~0.8% in the population after age 50, and the prevalence rate is rapidly increasing with the recent worldwide aging trend. Based on International Classification of Diseases, Tenth Revision, a global classification of disease published by the World Health Organization, issued the disease code (M62.84) given to sarcopenia in 2016. Therefore, it is expected that the study of sarcopenia will be further activated based on the classification of disease codes in the aging society. Several epidemiological studies and meta-analyses have looked at the correlation between the prevalence of sarcopenia and several environmental factors. In addition, studies using cell lines and rodents have been done to understand the biological mechanism of sarcopenia. Laboratory rodent models are widely applicable in sarcopenia studies because of the advantages of time savings, cost saving, and various analytical applications that could not be used for human subjects. The rodent models that can be applied to the sarcopenia research are diverse, but a simple and fast method that can cause atrophy or aging is preferred. Therefore, we will introduce various methods of inducing muscular atrophy in rodent models to be applied to the study of sarcopenia.
Software Application for Organizational Sustainability Performance Assessment

Sustainability performance assessment is a challenge for many companies due to the heterogeneity of indicators and the lack of a standardized reporting framework. This paper describes a software solution that simplifies the sustainability reporting process and is useful for decisions concerning sustainable management. We analyzed various indicators from public sustainability reports of five companies and obtained some relevant results using the tool that we developed based on mathematic algorithms and an aggregation model of different indicators. The software application calculates a Global Sustainability Index based on the proposed model of the sustainable organization described in this paper. An optimal solution is very rare in the transition towards the sustainable organization and compromises are required most frequently between environmental, economic and social aspects on the one hand and the expectations of the stakeholders on the other hand. The proposed tool helps users to cope with these challenges and takes into consideration that information is not always available and precise. Another feature offered by the tool is that besides simplifying sustainability performance assessment, it highlights low performance indicators and offers suggestions for improvement based on a genetic algorithm.
Inkjet 3D Printed MEMS Vibrational Electromagnetic Energy Harvester

Three-dimensional (3D) printing is a powerful tool that enables the printing of almost unlimited geometry in a few hours, from a virtual design to a real structure. In this paper, we present a micro-electromechanical energy harvester that utilized a 3D printed micromechanical structure combined with a miniature permanent magnet and a microelectronic coil towards a hybrid electromagnetic vibrational hybrid energy harvester. Various micromechanical structure geometries were designed, printed, and tested. The characteristic dimensions of the springs were from 200 μm to 400 μm and the total volume of the devices was below 1 cm3. The resonant frequencies (95–340 Hz range), as well as bandwidths (6–23 Hz range), for the developed prototypes were determined. The maximal generated output power was almost 24 μW with a power density up to almost 600 μW/cm3.
Population Trends of Monarchs at a Northern Monitoring Site: Analyses of 19 Years of Fall Migration Counts at Peninsula Point, MI

ABSTRACT Annual estimates of population size are important for tracking long-term population trajectories. There is concern that monarch butterflies (Danaus plexippus L.) in eastern North America are declining because the Mexican overwintering colonies have been shrinking over the past 20 yr. We examined a 19-yr data set of fall monarch censuses at a site in northern Michigan (Peninsula Point) to determine if the number of monarchs counted here has changed over time. At this site, volunteers walk a standardized transect daily during the fall to record migratory monarchs. Our secondary goal was to evaluate the relationship between the annual numbers at Peninsula Point and the size of the subsequent overwintering colonies. A statistical model that included multiple predictors of 1,793 census counts revealed a small but significant positive effect of year on counts, but the mean annual count number was not significantly correlated with year. In either case, we found no evidence for declines in monarch abundance. We also found no relationship between annual estimates of abundance at Peninsula Point and annual estimates of overwintering colony size. We interpret the disparity between long-term patterns here versus those in Mexico to be the result of mortality during migration or other factors that reduce migration success. Given this conclusion, we argue that preserving migratory habitats and resources, as well as reducing anthropogenic activities that hinder migration, should be the highest priorities for conserving monarchs in eastern North America.
Genetic diversity among natural populations of Mandevilla velutina

A batata-infalivel (Mandevilla velutina (Mart. Ex Stadelm) Woodson, Apocynaceae) e uma especie endemica do Cerrado, amplamente utilizada na medicina popular na forma de extrato alcoolico ou infusoes do sistema subterrâneo. A planta e utilizada no tratamento de processos inflamatorios e em acidentes com serpentes. Atualmente, esta especie e considerada prioritaria em programas de conservacao e, por isso, estudos de diversidade genetica e metodos de conservacao in vitro em bancos de germoplasma sao relevantes para evitar sua extincao. O objetivo deste trabalho foi estudar a variabilidade genetica em diferentes populacoes de batata infalivel por meio de marcador molecular RAPD visando fornecer subsidios para a conservacao da especie em bancos de germoplasma. A analise molecular de variância (AMOVA) revelou que a variabilidade dentro das populacoes (81,25%) foi maior que entre populacoes (18,75%). Esses resultados foram confirmados pelo Indice de diversidade de Nei. As estimativas de variacao de PHIST (0,188) e qP (0,1586) indicaram alta estruturacao populacional. Nao foi observada uma relacao direta entre as distâncias geneticas e geograficas das tres populacoes estudadas.
Outage Analysis of Heterogeneous mmWave Cellular Networks Employing JSDM

In this paper, the outage performance of a two-tier heterogeneous mmWave cellular networks employing joint spatial division and multiplexing (JSDM) is investigated. It is assumed that macro base stations (BSs) equipped with a large number of antennas and pico BSs equipped with single antenna serve users simultaneously. The two-tier BSs and users are distributed according to independent Poisson point processes (PPPs). Theoretical analysis of the signal-to-interference-plus-noise ratio (SINR) outage probability of the typical user is first provided. The all SINR outage probability of the two tiers is then derived. Simulation results in accordance with theoretical analysis demonstrating the performance improvement of two-tier networks compare with the single-tier network are provided. By using the noise-limited assumption for mmWave networks, a simpler expression to analyze the outage performance is obtained.
Antimicrobial resistance: the role of aquatic environments

Antimicrobial resistance is a major concern worldwide. Antibiotics are one of the most used drugs in humans and animals. The intensive use of antimicrobial agents is one of the main factors for the generation of resistant bacteria. Infections with resistant organisms and the emergence of multi-drug resistant pathogenic and non-pathogenic bacteria, represents an urgent global challenge since increases the incidence of morbidity and mortality and decreases the effectiveness of infectious diseases treatments. Many of the encoding antimicrobial resistant genes from human pathogens have originated in natural environments. Anthropogenic activities on aquatic environments, sediments and soils, such as hospital, pharmaceuticals and municipals discharges into rivers and lakes increase the generation of new resistance genes and the spread of resistant bacteria in the environment as well as in public health. This highlights the importance of the environment as a reservoir of resistance genes and dispersal vector. It is necessary to take measures to reduce the introduction and spread of resistant bacteria and its determinants in the environment, which could contain diverse chemicals, antibiotic residues or quaternary ammonium compounds. These measures include the management of wastewater treatment.
Low-Profile Omnidirectional WIFI Antennas With Pattern Reconfigurability Inspired by Meta-Resonators

A family of low-profile, omnidirectional antennas inspired by metamaterial resonators (meta-resonators) for WIFI applications is proposed. Two novel meta-resonators with an inductive feeding are presented. They can be considered as an LC resonant tank. Arbitrary size miniaturization could be obtained. Three rotated metamaterial unit cells constitute a ring-shaped structure, which generates a horizontally polarized, omnidirectional radiation. A direct microstrip power divider is used to excite them in-phase, achieving a small and low-profile magnetic dipole-like antenna. Their working principles are illustrated in detail by equivalent circuit and current distribution. Two omnidirectional antennas based on different meta-resonators and one pattern-reconfigurable antenna are fabricated and measured, respectively. Their measured −10 dB frequency bandwidth, peak gain, and radiation efficiency are greater than 2.4–2.48 GHz, 1.17 dBi, and 80%, respectively. They demonstrate superior advantages in terms of a miniaturized/low-profile size, simple structure, good bandwidth, and omnidirectional radiation performance, which are well positioned for 2.40 GHz WIFI router or indoor communications.
Plasma-induced catalysis: towards a numerical approach

A lattice Boltzmann (LB) model is developed, validated and used to study simplified plasma/flow problems in complex geometries. This approach solves a combined set of equations, namely the Navier–Stokes equations for the momentum field, the advection–diffusion and the Nernst–Planck equations for electrokinetic and the Poisson equation for the electric field. This model allows us to study the dynamical interaction of the fluid/plasma density, velocity, concentration and electric field. In this work, we discuss several test cases for our numerical model and use it to study a simplified plasma fluid flowing and reacting inside a packed bed reactor. Inside the packed bed, electric breakdown reactions take place due to the electric field, making neutral species ionize. The presence of the packed beads can help enhance the reaction efficiency by locally increasing the electric field, and the size of packed beads and the pressure drop of the packed bed do influence the outflux. Hence trade-offs exist between reaction efficiency and packing porosity, the size of packing beads and the pressure drop of the packed bed. Our model may be used as a guidance to achieve higher reaction efficiencies by optimizing the relevant parameters. This article is part of the theme issue ‘Fluid dynamics, soft matter and complex systems: recent results and new methods’.
The Influence of Palm Oil and Extracted Fishmeal on Growth Performance and Tissue Fatty Acid Composition of Heterobranchus Longifilis Fingerlings

Little is known about the effects of the dietary intake of palm o il and extracted fishmeal on growth performance and tissue fatty acid composition of Heterobranchus longifilis. Twenty H. Longifilis fingerlings were allotted for each treatment tanks in triplicate groups at random and were fed ten isonitrogenous and isoenergetic diets during a 12-week feeding trial. Diets were prepared by replacing fish oil with palm oil (PO) at 0, 25, 50, 75 or 100% (of fish oil) in ext racted and un-ext racted fishmeal-based diets in a 2 x 5 factorial design. Feeding H. longifilis fingerling with various levels of PO did not result in differences in fish growth and feed utilizat ion parameters (P > 0.05). This suggests that complete replacement of FO with PO can support growth comparable to a FO based diet. Ho wever, reduced growth and feed utilization parameter values were observed in H. longifilis fingerling fed un-extracted fishmeal-based diets (P < 0.05). Extract ion of lipids fro m fishmeal resulted in lower concentration of tissue eicosapentaenoic acid, docosahexaenoic acid and total n-3 PUFA (p < 0.05). While the tissue concentration of saturated, monounsaturated, n-9, n-6 and 18:2n-6 fatty acids increased in the extracted than the un-ext racted groups (P < 0.05). PO and ext racted fishmeal resulted in increased index of atherogenicity and index of thrombogenicity of the fillet (P < 0.05), but the value was less than 1.00 considered to be healthy for human consumer. Fro m the results of this study we conclude that H. longifilis fingerling be fed diets containing PO and extracted fishmeal, to enhance fish growth, survival and feed efficiency.
Maternal Role Attainment in Mothers with Term Neonate: A Hybrid Concept Analysis

Background: A review of the literature shows that there is little consensus on the practical definition of maternal role attainment in the field of neonatal nursing care. The initial interaction between mother and neonate most often begins in the hospital and can be influenced by neonatal nurses, so it is necessary to clarify this concept in nursing. The purpose of this study was to show the basic characteristics and practical definition of maternal role attainment in mothers with term neonate in a new context. Materials and Methods: This study used a hybrid model three-step concept analysis: theoretical, fieldwork, and final analysis phases. At theoretical phase, articles indexed in credential databases were searched using keywords. Totally, 33 articles were analyzed. At fieldwork phase, 12 participants were interviewed. At final phase, the findings of the two earlier phases were analyzed. The study lasted from August to November 2018. After determining the attributes, antecedents, and consequences, a final definition of maternal role attainment was introduced. Results: The concept of maternal role attainment was defined as “a developmentally, interactive, adaptive, and committed multi-dimensional process based on the discovery of pregnancy, characteristics of the mother, receiving social support, which leads to maternal identity, formation of maternal skills, resiliency, development of newborn, improvement of mother-newborn interactions and increased well-being of the mother”. Conclusions: This study identifies the concept of maternal role attainment in nursing, providng a good basis for evaluating and applying this concept.
Heterologous Expression of Novel Cytochrome P450 Hydroxylase Genes from Sebekia benihana

Actinomycetes are ubiquitous Gram-positive soil bacteria and a group of the most important industrial microorganisms for the biosynthesis of many valuable secondary metabolites as well as the source of various bioconversion enzymes. Cytochrome P450 hydroxylase (CYP), a heme-binding protein, is known to be involved in the modification of various natural compounds, including polyketides, fatty acids, steroids, and some aromatic compounds. Previously, six different novel CYP genes were isolated from a rare actinomycetes called Sebekia benihana, and they were completely sequenced, revealing significant amino acid similarities to previously known CYP genes involved in Streptomyces secondary metabolism. In the present study, these six CYP genes were functionally expressed in Streptomyces lividans, using an ermE* promoter-containing Streptomyces expression vector. Among six CYP genes, two S. benihana CYP genes (CYP503 and CYP504) showed strong hydroxylation activities toward 7-ethoxycoumarin. Furthermore, the recombinant S. lividans containing both the S. benihana CYP506-ferredoxin genes as well as the S. coelicolor feredoxin reductase gene also demonstrated cyclosporin A hydroxylation activity, suggesting potential application of actinomycetes CYPs for the biocatalysts of natural product bioconversion.
Effects of Algal Excreted Substances on the Respiration Activities of Epiphytic Bacteria on the Brown Alga, Eisenia bicyclis Kjellman

The respiration activity of epiphytic bacteria on Eisenia bicyclis Kjellman was determined by using 2-(p-iodophenyl)-3-(p-nitrophenyl)-5-phenyl tetrazolium chloride (INT). In June and August, the per centage of active bacteria on the surface of new blades were 59.6% and 51.6% respectively and that on old blades was almost 100%. The bacterial respiration activity became low when the blades were incu bated in the light. The phenol excretion rate from algal blades was high in new blades and in the light. These results suggested that epiphytic bacterial activity on E. bicyclis is suppressed by excreted algal phenols.
Epidemiology of Atrial Fibrillation in the 21st Century

Supplemental Digital Content is available in the text. Accompanying the aging of populations worldwide, and increased survival with chronic diseases, the incidence and prevalence of atrial fibrillation (AF) are rising, justifying the term global epidemic. This multifactorial arrhythmia is intertwined with common concomitant cardiovascular diseases, which share classical cardiovascular risk factors. Targeted prevention programs are largely missing. Prevention needs to start at an early age with primordial interventions at the population level. The public health dimension of AF motivates research in modifiable AF risk factors and improved precision in AF prediction and management. In this review, we summarize current knowledge in an attempt to untangle these multifaceted associations from an epidemiological perspective. We discuss disease trends, preventive opportunities offered by underlying risk factors and concomitant disorders, current developments in diagnosis and risk prediction, and prognostic implications of AF and its complications. Finally, we review current technological (eg, eHealth) and methodological (artificial intelligence) advances and their relevance for future prevention and disease management.
Sensory Quality of Shrikhand Prepared by Using Cardamom and Saffron

Shrikhand was prepared by adopting standard procedure. Freeze dried Dahi culture LF – 40, was used, which was obtained from NDRI Karnal. The product was served to a panel of semi trained judges to know its acceptability. The data so obtained was pooled and overall acceptability was worked out. The Shrikhand prepared by 0.020 per cent saffron and 0.50 per cent cardamom and 40 per cent sugar was superior in the colour and appearance, body and texture, flavour and overall acceptability of treatment T 4 secured maximum score than treatments T 0 , T 1 , T 2 , T 3 , respectively. But treatments Twhich prepared by addition of 0.020 per cent saffron and 0.25 per cent cardamom which secured highest score for acidity and similar score for body and texture was 8.31 and 8.36, respectively.
Design of a FOSS system for flood disaster management

In this paper we study how information technology solutions can be used when disasters strike. This research in progress focuses on flood disasters and it proposes the design for flood disaster management. To increase the utility of the disaster management information system, we follow the free and open source system (FOSS) concept. Informed by the management tasks of flood response, we elaborate the system requirements and key functionalities. The system has received preliminary evaluation by the domain experts and is currently under further development.
The Relative Effect of Two High Levels of an Antibiotic on Laying Chickens During Hot Weather

ABSTRACT HEYWANG (1956) reported that the egg production of White Leghorns was increased during hot weather when chlortetracycline was in their diet at the level of either 50 or 100 grams per ton, but the data obtained were not considered extensive enough to show whether the lower level was as effective as the higher. The results indicated that the increase in egg production was greater among the poor than among the good layers. Although it was believed that insufficient data were obtained to warrant definite statements, the trends toward greater egg production during cooler weather appeared similar to those during hot weather. Since that report was prepared an experiment designed to obtain information on whether chlortetracycline is as effective at the 50 as at the 100 gram per ton of diet level in increasing the egg production of White Leghorns during hot weather was conducted at the Southwest Poultry Experiment Station, .
A New Therapeutic Framework for Atrial Fibrillation Drug Development

Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia and cause of significant morbidity and mortality. Its increasing prevalence in aging societies constitutes a growing challenge to global healthcare systems. Despite substantial unmet needs in AF prevention and treatment, drug developments hitherto have been challenging, and the current pharmaceutical pipeline is nearly empty. In this review, we argue that current drugs for AF are inadequate because of an oversimplified system for patient classification and the development of drugs that do not interdict underlying disease mechanisms. We posit that an improved understanding of AF molecular pathophysiology related to the continuous identification of novel disease-modifying drug targets and an increased appreciation of patient heterogeneity provide a new framework to personalize AF drug development. Together with recent innovations in diagnostics, remote rhythm monitoring, and big data capabilities, we anticipate that adoption of a new framework for patient subsegmentation based on pathophysiological, genetic, and molecular subsets will improve success rates of clinical trials and advance drugs that reduce the individual patient and public health burden of AF.
Nutritive Value of the Water Fern Azolla pinnata for Chicks

Abstract The water fern Azolla pinnata, capable of assimilating atmospheric N2 due to the presence of algal symbiont in its leaves, was found to be rich in protein, minerals, chlorophylls, and carotenoids. Feeding studies with chickens revealed that inclusion of fresh Azolla in the diet can replace about 20% of commercial feed.