Miracle-dz/UniFAR-FTUs huggingface dataset:
Differential Rheology Among ABO Blood Group System In Nigerians

Background : ABO blood groups have been reported to have rheological significance and association with different disease conditions. The non-O blood groups (A, B, and AB) have shown more susceptibility to arterial and venous thrombotic diseases with no rheological delineation. The determinants of these blood groups are based on the presence or absence of the inherited antigenic substances on the erythrocyte membrane which are responsible for the alterations in membrane and cytoskeletal properties that could affect the rheology of blood. This study was therefore aimed at ascertaining how the varying membrane biochemical antigenic architecture affects the erythrocyte’s rheological properties and that of the whole blood. Methods : A total of 138 young healthy subjects were studied; they comprised 40, 38, 50 and 10 subjects divided into blood groups (A, B, and O and AB) respectively. Hemorheological parameters such as Relative plasma viscosity (RPV), Hematocrit (HCT), Plasma Fibrinogen concentration (PFC), White blood cell count (WBC), Red blood cell count (RBC), Platelet count, Hemoglobin concentration (Hb) and Erythrocyte deformability (ED) were analyzed. The transit time model (the higher the transit time, the lesser the deformability) was used in analyzing RBC deformability. Results : We observed that blood group AB had significantly higher values of PFC, RPV and Platelet counts but significantly lower transit time (p A>O>AB (p<0.05, respectively). Conclusion : In conclusion, blood group AB seems to have a positive advantage of better RBC deformability despite its comparatively high RPV. This shows that hemorheological variations exists amongst the ABO blood groups and the red cell antigenic biochemistry may be a determinant of their membrane mechanical properties. Also, a slight increase in Plasma Fibrinogen Concentration seems to have a significantly profound effect on plasma viscosity and indeed RBC deformability via transit times. Keywords : Hemorheology, Deformability, Plasma Viscosity, Transit time, antigenic biochemistry
Polarimetric characteristics of specular and dense multipath components in an industrial hall

This contribution analyzes the cross-polarization discrimination and the co-polar ratio of channel sounding data in a large industrial hall. The polarimetric parameters are calculated for the complete channels including measurement antennas, and for the specular and dense multipath components estimated with the RiMAX algorithm. The main observation is that horizontally polarized waves in the specular and dense part of the channel undergo an equal amount of depolarization while the depolarization of vertically polarized waves seems to be more pronounced in the dense part. A physical explanation for this observation based on the hall’s high ceiling is given.
Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT 3 ( ITD )-positive leukemia cells to PARP 1 inhibitors Short title : FLT 3 and PARP 1 inhibitors against AMLs

Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le, Martyna Solecka, Zhaorui Lian, Elizaveta A. Belyaeva, Alina Nersesyan, Marcin M. Machnicki, Monika Toma, Nicolas Chatain, Malgorzata Rydzanicz, Huaqing Zhao, Jaroslav Jelinek, Katarzyna Piwocka, Tomasz Sliwinski, Tomasz Stoklosa, Rafal Ploski, Thomas Fischer, Stephen M. Sykes, Steffen Koschmieder, Lars Bullinger, Peter Valent, Mariusz Wasik, Jian Huang, and Tomasz Skorski
Model for Integrating Home–Work Tour Scheduling with Time-Varying Network Congestion and Marginal Utility Profiles for Home and Work Activities

The existing literature on activity-based modeling emphasizes that individuals schedule their activities by keeping the whole-day activity pattern in mind. Several attempts have been made to integrate this with network congestion; however, for explicit explanation of travel behavior of individuals, further improvements are required. The proposed model is a combined model that addresses the scheduling of the home–work tour with time-varied network congestion in a fixed-point problem framework. Marginal utility profiles that represent individual time-of-day preferences and satiation effect of the activities are incorporated for the measurement of the utility of activity engagement along with the disutility of travel. Consideration of only time-of-day dependent marginal utility profiles of activities in the utility function does not appropriately integrate activities and travel within the tour. The proof is shown analytically and numerically. This finding contradicts earlier research into integration of morning and evening commutes with network congestion. Additionally, the results of two numerical experiments are presented. In the first experiment, an arbitrary dynamic tolling strategy is assumed, and then a detailed analysis is performed to show variation in the balance of trade-offs involved in the process. The second experiment assesses the sensitivity of the combined model through incorporation of different dynamic traffic loading models. Some meaningful observations are drawn from these experiments and are discussed with the identification of avenues for future research.
THE FACTORS INFLUENCING AUDITOR INDEPENDENCE: THE PERCEPTIONS OF AUDITORS IN BAHRAIN

The aim of this research is to assess the relationship between the presumed AI influencing factors and AI from the standpoint of auditors in Bahrain. Researchers have continuously identified and assessed several factors that are expected to safeguard AI and objectivity to mitigate the potential threats faced by the audit profession worldwide. As a result of the promising Bahrain Economic Vision 2030 that emphasizes on ‘fairness’ as a one of major principle, the regulators in Bahrain are expected to adopt new measures that enhance the role of auditors in maintaining fairness and transparency. This research hence investigated the subject matter in a way that intended to assess the AI influencing factors in a Bahraini context. The research is quantitative in nature, whereby questionnaires were distributed to a range of auditors representing the audit firms in the Kingdom of Bahrain. Following reliability and validity tests, the responses were analyzed descriptively, along with empirical analysis through using the Multiple Regression Model. The findings signified the substantial role of the audit regulations and related provisions in enhancing AI and impartiality, when compared to other presumed factors. The research recommendations focused on the importance of overseeing the audit firms and accounting professionals through the formation of an independent audit quality board as well as considering the adoption of a joint-audit practice for the listed companies.
Runing title:Virulence-related quasispecies detection by UDPS

5 Chunchun Meng, Xusheng Qiu, Shengqing Yu, Chuanfeng Li, Yingjie Sun, Zongyan 6 Chen, Kaichun Liu, Xiangle Zhang, Lei Tan, Cuiping Song, Guangqing Liu, Chan 7 Ding* 8 9 Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 10 518 Ziyue Road, Shanghai, P. R. China 200241 11 12 *Corresponding Author 13 Address: 518 Ziyue Road, Shanghai, P. R. China 200241 14 Phone: 086-21-34293441 15 Fax: 086-21-54081818 16 E-mail address: shoveldeen@shvri.ac. cn 17 18
Patient report

Objectives: Camurati-Engelmann disease (CED) is a rare form of progressive diaphyseal dysplasia as a result of mutations in the transforming growth factor gene TGFbeta1 on chromosome 19q13.1-q13.3. Endocrine complications such as osteoporosis, vitamin D deficiency, delayed puberty, and hypogonadotrophic hypogonadism may be present. Methods: Genetic analysis of the TGFbeta1 gene revealed a heterozygous missense mutation p.R218C in exon 4 of chromosome 19q13.1-q13.3 in a 14-year-old girl who presented with typical symptoms of CED, hyperprolactinaemia, and menstrual irregularity. Results: The patient responded well to prednisone 5 mg/kg/day, as well as calcium and vitamin D supplements. Conclusions: The role of p.R218C in TGFbeta1 on the mechanism of the disease, and the complications of it in bones and endocrine glands, remains unclear. Early recognition as well as a detailed understanding of the pathogenesis of the disease are important for future treatment options and a better quality of life of such patients.
Evolution of nonlinear ion-acoustic solitary wave propagation in rotating plasma

A simple unmagnetized plasma rotating around an axis at an angle θ with the propagation direction of the acoustic mode has been taken. The nonlinear wave mode has been derived as an equivalent Sagdeev potential equation. A special procedure, known as the tanh method, has been developed to study the nonlinear wave propagation in plasma dynamics. Further, under small amplitude approximation, the nonlinear plasma acoustic mode has been exploited to study the evolution of soliton propagation in the plasma. The main emphasis has been given to the interaction of Coriolis force on the changes of coherent structure of the soliton. The solitary wave solution finds the different nature of solitons called compressive and rarefactive solitons as well as its explosions or collapses along with soliton dynamics and these have been showing exciting observations in exhibiting a narrow wave packet with the generation of high electric pressure and the growth of high energy which, in turn, yields the phenomena of radiating s.
aphy to compare creative Using linkogr methods for group ideation

This paper compares a new creative design method, based on the principles of drama improvisation, with brainstorming. The evolution and development of the Design Improv method is reviewed, and the results of an evaluation of both methods in controlled team ideation sessions are documented. The creative characteristics relevant to their quantitative and visual interpretation are analysed using linkography, identifying the most prominent variations in performance with respect to inter-connectedness, parallel thinking and idea diversity. We describe an adapted and expanded process for robust linkograph development and reflect on the value, challenges and limitations of both the linkograph creation and the perceptive insights they can provide. 2018 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Binge Drinking and Military Setting

Background: The aim of the present study was to examine patterns of binge drinking at military service.Method: 612 paired soldiers serving in the Israeli Defense Forces. Data consisted of self-report questionnaires demographic variables.Findings: Higher rates of binge drinking were found among males, lower education, and lower intellectual scores. Among the 67 soldiers in combat units a significant correlation of 0.32, between those who reported binge drinking at recruitment and those who reported binge drinking at discharge, was found.Conclusion: Rereported binge drinking among combat soldiers did not increase over the course of their military service.
Control Design for an Industrial Boiler

In the control of an industrial boiler system, multi-loop (decentralized) PI control is used because of its simplicity and the existence of simple on-line tuning rules. We show that such control schemes sacrifices robustness and performance of the overall system. In particular, under normal boiler operating conditions, we design a robust multivariable controller using the Hoo loop-shaping technique. For reason of implementation, we then reduce this controller to a multivariable PI structure. Both the Hoo controller and its PI approximation are tested extensively in the frequency domain as well as in the time domain, using a complex nonlinear simulation software; the results show that the designed controllers are superior in robustness and performance compared to the existing multi-loop controller.
Trial ( NASCET ) and the other according to the European Carotid Surgery

Carotid stenoses of 50% account for about 15–20% of strokes. Their degree may be moderate (50–69%) or severe (70–99%). Current diagnostic methods include ultrasound, MRor CT-angiography. Stenosis severity, irregular plaque surface, and presence of microembolic signals detected by transcranial Doppler predict the early recurrence risk, which may be as high as 20%. Initial therapy comprises antiplatelets and statins. Benefit of revascularization is greater in men, in older patients, and in severe stenosis; patients with moderate stenoses may also profit particularly if the plaque has an irregular aspect. An intervention should be performed within <2 weeks. In large randomized studies comparing endarterectomy and stenting, endovascular therapy was associated with a higher risk of periprocedural stroke, yet in some studies, with a lower risk of myocardial infarction and of cranial neuropathy. These trials support endarterectomy as the first choice treatment. Risk factors for each of the two therapies have been indentified: coronary artery disease, neck radiation, contralateral laryngeal nerve palsy for endarterectomy, and, elderly patients (>70 years), arch vessel tortuosity and plaques with low echogenicity on ultrasound for carotid stenting. Lastly, in direct comparisons, a contralateral occlusion increases the risk of periprocedural complications in both types of treatment. I. Momjian-Mayor, P. Burkhard, N. Murith, D. Mugnai, H. Yilmaz, A. -P. Narata, K. Lovblad, V. Pereira, M. Righini, H. Bounameaux, R. F. Sztajzel Neurology Department, Faculty of Medicine, Geneva University Hospitals, University of Geneva, Geneva, Switzerland; Cardio-Vascular Surgery Department, Faculty of Medicine, Geneva University Hospitals, University of Geneva, Geneva, Switzerland; Neuroradiology Department, Faculty of Medicine, Geneva University Hospitals, University of Geneva, Geneva, Switzerland; Angiology and Haemostasis Department, Faculty of Medicine, Geneva University Hospitals, University of Geneva, Geneva, Switzerland
Repellents with potential to protect kea and other native birds from aerial poisoning for possum and rat control

Concern about non-target risks to native birds, particularly kea (Nestor notabilis), from aerial poisoning has prompted the evaluation of potential repellent compounds that could be incorporated into the cereal pellet bait used for possum (Trichosurus vulpecula) and rat (Rattus spp.) control. Initial trials of d-pulegone and anthraquinone were not wholly successful, with the former having poor stability in bait and the latter reducing bait uptake by rats. While research to stabilise d-pulegone in bait remains an option, a review of alternative compounds was undertaken to assist with decision-making about future directions for research, including consideration of possible formulation issues and cost. Most of the information reviewed related to use of repellents for crop protection where the aim is to reduce economic loss rather than prevent feeding on the crop, whereas preventing feeding is the primary aim for native bird protection. A further constraint was the lack of information for many compounds on response of rodents and possums. Cinnamamide, tannic acid, caffeine, garlic oil, ortho-aminoacetophenone, and thiram were identified as possible candidates and evaluated in relation to their potential to repel native birds from eating cereal baits without affecting efficacy for possums and rats. Cinnamamide, caffeine, and thiram, while effective as bird repellents, are likely to be repellent to rats at concentrations suitable for use with native birds, including kea. The little information found suggested that garlic oil was repellent to birds; it has not been formally tested on possums and rats, but anecdotal evidence did not suggest strong aversion. Ortho-aminoacetophenone appears effective as a bird repellent, but its repellency for possums and rats requires clarification. Tannic acid has some efficacy as a bird repellent, and is not repellent to possums and rats at lower concentrations. It is not clear if tannic acid exerts its effect solely as a primary repellent or whether it also has secondary repellent effects. In order from most to least promising, tannic acid, ortho-aminoacetophenone, and garlic oil are worthy of further investigation. Because each compound has demonstrated some efficacy as a bird repellent, initial testing should focus on screening against possums and rats.
médicales ost-transfusional iron overload in the haemoglobinopathies rcharge en fer post-transfusionnelle dans les hémoglobinopathies abelle Thuret

In this report, we review the recent advances in evaluation and treatment of transfusional iron overload (IO). Results of the French thalassaemia registry are described. According to the disease, thalassaemia major or sickle cell anaemia, mechanisms and toxicity of iron overload, knowledge about IO long-term outcome and chelation treatment results, respective value of IO markers, differ. The recent tools evaluating organ specific IO and the diversification of iron chelator agents make possible to individualize chelation therapy in clinical practice. The severity of IO and the level of transfusional iron intake, the preferential localization of IO (heart/liver) as well as the tolerance and adherence profiles of the patient can now be taken into account. Introduction of cardiac magnetic resonance imaging for the quantification of myocardial iron and use of oral chelators have already been reported as decreasing the cardiac mortality rate related to IO in thalassaemia major patients. Long-term observation of patients under oral chelators will show if morbidity is also improving via a more continuous control of toxic iron and/or a better accessibility to cellular iron pools. 2012 Académie des sciences. Published by Elsevier Masson SAS. All rights reserved.
Contributes to Tumorigenesis in Thyroid Carcinoma-Catenin Signaling Pathway β − A Novel RET Kinase

The RET receptor tyrosine kinase has essential roles in cell survival, differentiation, and proliferation. Oncogenic activation of RET causes the cancer syndrome multiple endocrine neoplasia type 2 (MEN 2) and is a frequent event in sporadic thyroid carcinomas. However, the molecular mechanisms underlying RET’s potent transforming and mitogenic signals are still not clear. Here, we show that nuclear localization of Bcatenin is frequent in both thyroid tumors and their metastases from MEN 2 patients, suggesting a novel mechanism of RET-mediated function through the B-catenin signaling pathway. We show that RET binds to, and tyrosine phosphorylates, B-catenin and show that the interaction between RET and B-catenin can be direct and independent of cytoplasmic kinases, such as SRC. As a result of RETmediated tyrosine phosphorylation, B-catenin escapes cytosolic down-regulation by the adenomatous polyposis coli/ Axin/glycogen synthase kinase-3 complex and accumulates in the nucleus, where it can stimulate B-catenin–specific transcriptional programs in a RET-dependent fashion. We show that down-regulation of B-catenin activity decreases RET-mediated cell proliferation, colony formation, and tumor growth in nude mice. Together, our data show that a Bcatenin–RET kinase pathway is a critical contributor to the development and metastasis of human thyroid carcinoma. [Cancer Res 2008;68(5):1338–46]
On the Performance of Neural Networks for Face Recognition: Linear or Nonlinear Classifiers?

The main goal of this study is to empirically evaluate linear and nonlinear neural network based classifiers to be embedded in mobile devices. For this purpose, this paper reports a comprehensive performance comparison study involving 10 neural network models for human face recognition. All the classifiers are evaluated on two benchmarking face databases. For the linear classifiers we evaluate eight variants of the LMS and perceptron learning rules, while for the nonlinear ones we evaluate two state-of-the-art classifiers. In addition, we also evaluate empirically the robustness of all classifiers to the presence of gaussian and impulsive noise in test images. The results of the experiments indicate that the linear classifiers perform as good as nonlinear ones, with the advantage of demanding much lower computational resources.
CHD 4 is a dynamic component of the NuRD complex 1 CHD 4 is a Peripheral Component of the Nucleosome Remodeling and Deacetylase Complex

Chromatin remodeling enzymes act to dynamically regulate gene accessibility. In many cases, these enzymes function as large multicomponent complexes that, in general, comprise a central ATP-dependent Snf2-family helicase that is decorated with a variable number of regulatory subunits. The Nucleosome Remodeling and Deacetylase complex (NuRD), which is essential for normal development in higher organisms, is one such macromolecular machine. The NuRD complex comprises approximately 10 subunits, including the histone deacetylases 1 and 2 (HDAC1 and HDAC2), and is defined by the presence of a CHD-family remodeling enzyme – most commonly Chromodomain Helicase DNAbinding protein 4 (CHD4). The existing paradigm holds that CHD4 acts as the central hub upon which the complex is built. We show here that this paradigm does not, in fact, hold and that CHD4 is only a peripheral and dynamic component of the NuRD complex. A complex lacking CHD4 that has HDAC activity can exist as a stable species in cells. The addition of recombinant CHD4 to this Nucleosome Deacetylase (NuDe) complex reconstitutes a NuRD complex with nucleosome remodeling activity. These data are an important step towards understanding the architecture of the NuRD complex. Nucleosomes effectively act as a roadblock to all aspects of genome biology. ATPdependent chromatin remodeling enzymes solve this problem by using ATP-derived energy to alter the positions, occupancy and composition of nucleosomes. All remodelers possess a highlyrelated ATPase motor domain from the helicase family and are classified into four subfamilies (INO80, ISWI, SWR1 and CHD) based on sequence similarity (1). Each subfamily is represented in nearly all eukaryotes, suggesting that they catalyse different remodeling events. For example, ISWI proteins reposition (or slide) nucleosomes to create regularly spaced arrays; this periodic organisation is a key characteristic of DNA at the start of genes (2). SWR1 and INO80 enzymes have opposing roles in histone variant dynamics; the former incorporates these histone variants (e.g., H2A.Z) while the latter removes them. These variants set up specific chromatin structures that modulate transcription and replication, although the roles of many variants are http://www.jbc. org/cgi/doi/10.1074/jbc.M115.707018 The latest version is at JBC Papers in Press. Published on May 27, 2016 as Manuscript M115.707018 Copyright 2016 by The American Society for Biochemistry and Molecular Biology, Inc. by gest on M ay 1, 2016 hp://w w w . jb.org/ D ow nladed from CHD4 is a dynamic component of the NuRD complex