Miracle-dz/UniFAR-FTUs huggingface dataset:
Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief Review

Human papillomaviruses (HPVs) and the Epstein–Barr virus (EBV) are the most common oncoviruses, contributing to approximately 10%–15% of all malignancies. Oncoproteins of high-risk HPVs (E5 and E6/E7), as well as EBV (LMP1, LMP2A and EBNA1), play a principal role in the onset and progression of several human carcinomas, including head and neck, cervical and colorectal. Oncoproteins of high-risk HPVs and EBV can cooperate to initiate and/or enhance epithelial-mesenchymal transition (EMT) events, which represents one of the hallmarks of cancer progression and metastasis. Although the role of these oncoviruses in several cancers is well established, their role in the pathogenesis of colorectal cancer is still nascent. This review presents an overview of the most recent advances related to the presence and role of high-risk HPVs and EBV in colorectal cancer, with an emphasis on their cooperation in colorectal carcinogenesis.
Covid-19: Keep essential malaria services going during pandemic, urges WHO

Deaths from malaria in sub-Saharan Africa could return to levels last seen 20 years ago because of severe disruptions in access to nets and medicines during the covid-19 pandemic, a new modelling analysis has shown. The World Health Organization is urging countries to do their utmost to safely maintain essential malaria control services, especially during a “critical window of opportunity” before the peak season, which follows the rainy season. Otherwise, WHO warns, deaths could double from 380 000 in 2018 to 769 000 in 2020.1 Speaking ahead of World Malaria Day on 25 April, WHO’s regional director for Africa, Matshidiso Moeti, said, “We haven’t seen mortality levels like that in 20 years. We must …
One ventilator for two patients: feasibility and considerations of a last resort solution in case of equipment shortage

The present emergency caused by the spread of the Covid-19 infection is putting enormous pressure on the healthcare systems worldwide and especially on intensive care units (ICUs). One of the main fears in this regard is that we may run out of ventilators, a possibility which is getting more and more likely as the pandemic spreads throughout the world and the ICUs are overloaded with ventilated patients. Many authors have already investigated the possibility of manipulating a ventilator circuit in order to ventilate up to four patients with a single machine. Neyman and Ervin first performed a bench study demonstrating the technical feasibility of ventilating four patients with one ventilator and one modified circuit.1 The same circuit configuration was used in 2008 by Paladino et al in an animal model, resulting in substantial differences in oxygenation and decarboxylation between subjects during the ventilation period.2 In 2012 Branson et al tested in vitro the Neyman and Ervin system simulating different conditions of compliance and resistance between the simultaneously ventilated test lungs. They observed wide variability in measured tidal volume (Vt) and end-expiratory lung volume, so they concluded that the technique should be avoided because of potential danger.3 Accordingly, the authors argued that the stockpiling of ventilators should be the first-line solution when massive emergencies are forecast; only after their depletion, strategies such as the ‘double circuit’ should be implemented for the shortest possible duration.4 5 On 20 February 2020, the first case of Covid-19 emerged in the Lombardy region, northern Italy. As of 17 March, a total of 1069 patients had been admitted …
Systematic Review of Important Viral Diseases in Africa in Light of the ‘One Health’ Concept

Emerging and re-emerging viral diseases are of great public health concern. The recent emergence of Severe Acute Respiratory Syndrome (SARS) related coronavirus (SARS-CoV-2) in December 2019 in China, which causes COVID-19 disease in humans, and its current spread to several countries, leading to the first pandemic in history to be caused by a coronavirus, highlights the significance of zoonotic viral diseases. Rift Valley fever, rabies, West Nile, chikungunya, dengue, yellow fever, Crimean-Congo hemorrhagic fever, Ebola, and influenza viruses among many other viruses have been reported from different African countries. The paucity of information, lack of knowledge, limited resources, and climate change, coupled with cultural traditions make the African continent a hotspot for vector-borne and zoonotic viral diseases, which may spread globally. Currently, there is no information available on the status of virus diseases in Africa. This systematic review highlights the available information about viral diseases, including zoonotic and vector-borne diseases, reported in Africa. The findings will help us understand the trend of emerging and re-emerging virus diseases within the African continent. The findings recommend active surveillance of viral diseases and strict implementation of One Health measures in Africa to improve human public health and reduce the possibility of potential pandemics due to zoonotic viruses.
Bacterial analysis of semen and their antibiogram

The bacterial load in neat semen, diluted semen and frozen semen was assessed. Various organisms were isolated and identified up to their species level. Escherichia coli was the predominant organism isolated. Brucella abortus was isolated from semen samples. Antibiogram revealed that amikacin, chloramphenfcol and gentamicin were effective against isolated organisms. Pseudomonas species showed the highest resistance while Staphylococcus species were the most sensitive to the antibiotics tested. Most of the organisms were resistant to penicillin and streptomycin used in semen diluent.
Interfirm Arrangements in Different Institutional Environments

Abstract This paper aims to investigate the effect of the institutional environment variables on the organizational choice by franchise chains that share a business format. Inasmuch as this type of franchising requires strict standardization, a comparative analysis of the same franchise chain operating in different institutional environments allows for the control of several variables, such as product and firm strategies, so that the observed organizational differences may be attributed to institutional variables. Different rules of the game may explain different governance structures in the transaction between franchisor and franchisees and their procurement contracts. In this paper, we did case studies based on semi-structured interviews with procurement and franchising managers of McDonald's in France and Brazil. The main finding is that McDonald's uses in Brazil governance structures that provide more control on transactions, both in the transactions with their outlets and their suppliers. In accordance with our results, institutional environment features explains differences in the organizational choice in each country. Results suggest the need for further research in two directions: a larger sample of countries and the investigation of other franchise chains.
Psychoanalytic Treatment of an Asymptomatic HIV-Positive Gay Man

Abstract This paper describes the psychoanalytic treatment of an asymptomatic HIV-positive gay man. At present, the analysis is in its fifth year, and termination themes are apparent and central to the analysis, although a termination date has not yet been set. This patient presented a formidable challenge to psychoanalytic treatment, independently of his serological status. The patient's history of alcoholism, suicide attempts, depression requiring pharmacological maintenance, and his general proclivity to acting out, coupled with the restricted nature of his object relations, made the decision of whether to treat him with psychoanalysis versus psychoanalytic psychotherapy a very difficult one.
Uncomplicated Malaria in Children under 6 Months or Less than 5 Kg; How Prescribers in Ghana Manage it in the Absence of a National Policy

• Page 1 of 9 • Citation: Ameade EPK, Tee CG, Dakurah HC, Opata HM (2018) Uncomplicated Malaria in Children under 6 Months or Less than 5 Kg; How Prescribers in Ghana Manage it in the Absence of a National Policy. Int J Trop Dis 1:002. Accepted: July 18, 2018; Published: July 20, 2018 Copyright: © 2018 Ameade EPK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The In Situ Function of a Microbial Community Profiled by FT-IR: A Snapshot in Time

Photographs of an ecosystem are an important tool in macro-community ecology. The photograph is a permanent record of species phenotype. In microbiology, biochemical activity provides the most descriptive information of an organism " s phenotype. A method for fingerprinting all biochemical activities occurring within a microbial community is analogous to a photograph. Infrared spectroscopy in the region between wavelengths 2500 to 20,000 nm (mid-IR) is a well established instrumental method for fingerprinting the total biochemical profile of axenic cultures. Spectra are complex and sensitive as demonstrated by the ability to discriminate between strains of bacteria, fungi, and algae. This thesis develops the method to apply mid-IR spectroscopy in order to attain a biochemical fingerprint by attenuated total reflectance. Chapter 2 establishes methods for obtaining mid-IR spectra by prefiltering and concentrating lake water onto a 0.2 µm filter membrane. In order to optimize signal, a combined spectrum from PVDF and nylon membranes is used following a 20-25 µm prefilter. Chapter 3 verifies that the established method is capable of discriminating the biochemical fingerprints of six interdunal lakes from Western Nebraska with differing chemistries and community structures. Mid-IR spectra provide functional data, but do not mirror structure, based on 16S rRNA data, identically. Now, a record of biochemical activity within a microbial community can be captured for future comparison. This technique is culture-independent and provides functional, in situ information. In the future, more information can be deduced by comparing different functional communities to one another, assigning spectral information to particular biochemical activities in a community. ii Acknowledgments I would like to thank Dr. Kenneth Nickerson and Dr. Bradley Plantz for accepting me into their lab. Dr. Nickerson " s fascination in military history has always kept my interest and reminds me of where I came from and how I found myself in a biochemistry/biological sciences lab at the University of Nebraska-Lincoln. His knowledge in biochemistry and biological sciences has been the bedrock from which all of our studies have extended. Dr. Plantz " commitment to seeing our work come to fruition, and teaching me along the way, has been the key to my development. Without it, I never would have arrived at this point. Chairperson when I arrived and walked me through the entire application process to achieve acceptance from the University of Nebraska – Lincoln graduate studies. I am grateful to Dr. Julie Shaffer and Betty Jo Jacques for their assistance …
Inflammatory Cells and Mediators in CNS Disease

1. Unique Aspects of Inflammation in the Central Nervous System 2. Apoptosis in Neurodegenerative Diseases: New Therapeutic Opportunities 3. Stroke Studies with Anti-Inflammatory Agents 4. Cytokine Mechanisms in Induced Brain Tolerance to Injury 5. Selectins, ICAMs, and Integrins in CNS Injury 6. Cytokines in Acute Brain Injury and Stroke 7. Osteopontin in Oxidative Stress Responses 8. Gene Expression in Stroke 9. Neurogenomics and the Discovery of Novel Inflammatory Mediators in the
BOOK REVIEW ESSAYS

defy efforts to be classified into types, reduced to essential characteristics, y boundaries (intellectual or otherwise). Faced with these unruly realities, rists struggle to make sense of evolving urban forms. Speaking broadly, ongoing tension in the scholarly literature between viewing cities as physiwith varying morphological characteristics, on one hand, or seeing cities as t are experienced, imagined, and lived, on the other. The first approach lays stress on qualities that can be directly observed, measured, and quantified typical case, views cities through the lens of grids and zones, areas and concles. In contrast, the second approach focuses attention on those who city and the meanings that they give to the experience of living in urban e tensions between these alternative approaches to understanding
Symmetric sculpture

The extended face planes of symmetric polyhedra form a set of interconnected canvases that can be used as the framework for sculpture. Examples constructed from metal, wood, or acrylic plastic demonstrate the versatility of the approach. A special-purpose software tool is described which allows the artist to select families of such planes, to draw within them, to maintain constraints concerning points lying on their intersections, to view and modify the results interactively in real time, and to output the result for production either as 3D solid freeform fabrication or 2D laser-cutting or plasma cutting.
Editorial

In his book, How We Age: A doctor’s Journey into the Heart of Growing Old, Marc E. Agronin (2011) commented about the critical lesson of aging, saying that: “Even in the context of age-related intellectual decline and other losses, the enhanced capacity to love, create, and renew relationships is a gift of growing old not to be overlooked or trivialized” (p. 202). Similar sentiment is expressed by Nuland (2007), who argued that the most critical elements to successful aging include mutual caring and connectedness, as well as the maintenance of physical capacity and creativity. Building on the work of Erikson, Vaillant (2002) maintained, with his longitudinal data, that the key personal qualities that highlight good relationships in older age include forgiveness, gratitude, and loving kindness. The Jewish theologian Abraham Heschel taught us about spiritual wisdom in old age, suggesting that:
Long-Term Effectiveness, Safety and Mortality Associated with the Use of TC-325 for Malignancy-Related Upper Gastrointestinal Bleeds: A Multicentre Retrospective Study

Abstract Background and Study Aims Malignant-related upper gastrointestinal bleeding (MRUGIB) is difficult to treat by conventional endoscopic methods. We sought to determine the efficacy, safety and mortality associated with the use of TC-325 for the treatment of MUGIB. Patients and Methods This is a multicentre, retrospective study at the University of Calgary and University of Ottawa performed between January 1, 2010, and July 30, 2016. TC-325 use was identified via staff polling, product order forms and endoscopic records review. Once identified, patient charts and online records were examined to identify MRUGIB cases and to assess our primary and secondary endpoints. Outcomes The primary outcome was hemostasis at seven days. Secondary outcomes include immediate hemostasis, early hemostasis, hemostasis at 14 days, 30-day mortality, adverse events related to TC-325 therapy and the need for repeat endoscopic intervention, surgery or transarterial embolization. Results Twenty-five patients were identified. The median age was 62 years (interquartile range [IQR] 52.5–76), and most were male (64%). TC-325 was the primary treatment modality in 20 patients (80%). Hemostasis was 88%, 89%, 58% and 50% at 24 hours, 72 hours, 7 days and 14 days, respectively. Five patients underwent repeat endoscopy, two patients required surgical intervention, and transarterial embolization was not required. Twelve patients died by 30 days (48%). There were no complications directly attributed to the use of TC-325. Conclusions TC-325 is effective for achieving and maintaining hemostasis in patients with malignancy-related upper gastrointestinal bleeding, and most patients do not require additional interventions. The 30-day mortality risk in this group of patients is high.
BOOK AND MEDIA REVIEWS

Over the last 10 years, there has been a conspicuous increase in the number of educational texts that purport to address the conditions that characterize the experiences of ethnic students of color in America’s schools (Darder, Torres, & Gutirrez, 1997; Delpit, 1996; Ladson-Billings, 1994; Nakanishi & Nishida, 1995; Valencia, 1991, 2002; Wille, Garibaldi, & Reed, 1991). Significant demographic transitions, rather than subtle movements, continue to take place in urban and, most recently, in rural locales. Associated changes in student profiles have collectively evoked an equally significant response by the national educational apparatus. Educational workers from across the invested spectrum of potential stakeholders—that is, from teacher preparation professionals, classroom teachers, parents, students, through community leaders—are having to consider how they will begin the process of retooling education to best address the concerns of the nation’s students and its increasingly diverse complexion. The process of reconceptualizing the notion of “education as usual” in light of uncontestable demographic changes in America’s student population has necessitated the intensification of the development of resource materials that speak equally to the challenges and potential of the current generation of students in America’s schools and classrooms. Indeed, the recent proliferation of “ethnic” specific texts—including those that are offered under coded designations such as urban school students, inner-city students, disadvantaged students, ethnic and linguistically diverse students, and the like—purport to focus on the general theme of students of color. This body of work represents the realization throughout the most influential segments of the education community as to the immutable centrality that these once peripheral student JOURNAL OF LATINOS AND EDUCATION, 2(3), 183–186 Copyright © 2003, Lawrence Erlbaum Associates, Inc.
Physical and Mental Health Consequences of Obesity in Women

Obesity and overweight are major health concerns and the leading preventable cause of death in developed and developing countries. Obesity affects men and women dif - ferently due to biological, socioeconomic, cultural and country-specific gender-related disparities. This book chapter outlines obesity as a risk factor for physical diseases and mental health disorders in women. Obesity has been shown to contribute to the risk of certain types of cancer, including breast, endometrial, gallbladder, oesophageal and renal cancer. In terms of reproductive health, obesity negatively affects both fertility and contraception. In addition, obesity is associated with early miscarriage, higher rates of caesarean section and high-risk obstetrical conditions, in addition to higher maternal and neonatal mortality rates, and congenital malformations. In terms of mental health, obesity is closely linked to depression, anxiety disorders, neurodegenerative diseases and sleep disorders. Socioeconomic, psychosocial and behavioural factors, factors associated with ageing, mechanisms related to the microbiome, gastrointestinal and vascular system, intracellular pathophysiology and metabolism in the body, hormones, adipocy- tokines and problems associated with medical treatment are important factors linking obesity with its negative consequences on physical and mental health.
Lesbian, Gay, Bisexual, and Transgender People Receiving Services in the Public Mental Health System: Raising Issues

SUMMARY The growing literature about psychotherapy with LGBT clients rarely addresses serious mental illnesses or mental health care settings such as inpatient, psychosocial rehabilitation, day programs, or residential care. Nor does much of existing literature address the public mental health system. In 1997, the federal Center for Mental Health Services (part of Substance Abuse and Mental Health Services Administration and the federal Department of Health and Human Services) commissioned a review of current knowledge regarding the experiences, needs, and recommendations of LGBT people with serious mental illnesses. This article offers a summary of that multi-year project. Using qualitative methods and analysis, this study combines information from archival sources, published and unpublished literature, and key informant interviews to highlight questions and themes important to the welfare of lesbian, gay, bisexual and transgender (LGBT) people receiving public/community mental health services. This paper raises issues about the experiences and needs of these populations that would benefit from further investigation, to help pique further inquiry, and to suggest constructive interim steps.
Healing Images and Narratives: Undocumented Chicana/Latina Pedagogies of Resistance

ABSTRACT This article draws from a longitudinal study of 38 in-depth testimonio interviews with 10 undocumented Chicanas/Latinas from 2008 to 2014, first as college students and then as professionals. A Chicana feminist theoretical perspective in education was utilized to explore how undocumented Chicana/Latina ways of knowing emerged in the ways they worked with and for immigrant communities as professionals. The study found that participants drew from their multiple identities, social locations, and life experiences as undocumented Chicana/Latina women to engage in pedagogies of resistance—everyday forms of teaching and learning that challenge the subjugation of undocumented communities, and are shaped by personal and collective experiences, knowledge, and identities. The study found that participants utilized mestiza consciousness, convivencia, and bodymindspirit to employ these pedagogies of resistance in their professional work with and for immigrant communities.
An Intervention to Increase Fruit and Vegetable Consumption Using Audio Communications: In-Store Public Service Announcements and AudioTapes

Consumers make an estimated 70% of their food purchase decisions as they shop . Effective presentation of information about healthier food selections at the point - of purchase should have an impact on their decisions. This study was designed to evaluate the effectiveness of two audio formats on knowledge, attitudes, and beliefs about fruits and vegetables and on intake of these foods . Participants identified as "regular shoppers" (n = 374) in three intervention stores were recruited as they entered. They provided baseline demographic data, answered questions about their knowledge and beliefs about fruits and vegetables, and completed a checklist to assess fruit and vegetable intake. They were given two one - hour audiotapes and asked to play them within the next four weeks. In - store public service announce ments (PSAs) with information about fruits and vegetables were rotated every 30 minutes for four weeks. A control group (n = 378), recruited in three other stores matched by demographic characteristics , provided the same information. They received an audiotape with stress reduction information . At posttest, the original series of questionnaires were readministered in telephone interviews with 87.7% of the original intervention group and 93.7 % of the original control group. Knowledge scores in the intervention group increased significantly over baseline and as compared with the control group. Self-reported fruit and vegetable intake increased significantly in both groups, perhaps in part because of a seasonal effect. The increase from baseline was significantly higher in the intervention group and com pared with controls. These findings support the further exploration of the use of audiotapes in nutrition education interventions.