Miracle-dz/UniFAR-FTUs huggingface dataset:
Modified bagging of maximal information coefficient for genome-wide identification

A new method, modified Bagging mBagging of Maximal Information Coefficient mBoMIC, was developed for genome-wide identification. Traditional Bagging is inadequate to meet some requirements of genome-wide identification, in terms of statistical performance and time cost. To improve statistical performance and reduce time cost, an mBagging was developed to introduce Maximal Information Coefficient MIC into genome-wide identification. The mBoMIC overcame the weakness of original MIC, i.e., the statistical power is inadequate and MIC values are volatile. The three incompatible measures of Bagging, i.e. time cost, statistical power and false positive rate, were significantly improved simultaneously. Compared with traditional Bagging, mBagging reduced time cost by 80%, improved statistical power by 15%, and decreased false positive rate by 31%. The mBoMIC has sensitivity and university in genome-wide identification. The SNPs identified only by mBoMIC have been reported as SNPs associated with cardiac disease.
Circulating miRNAs: Potential Biomarkers for Diagnosis and Prognosis Prediction of Hematological Malignancies

MicroRNAs (miRNAs) are small non-coding, single-stranded, endogenous RNAs of 19-25nt in length. They are readily detected in body fluids including serum, plasma, urine, saliva, even circulating cancer cells. With the salient features as high stability, low cost, repeatability of sampling and minimal invasiveness, circulating miRNAs are ideal for development into diagnostic tests. Emerging evidences indicated that circulating miRNAs exert a role as noninvasive biomarkers for cancer diagnostic and prognostic indexes with prospective. In this mini review, emphasis will be given to the application of plasma or serum miRNAs as biomarkers for hematological malignancies focusing on the usefulness for diagnosis and prognosis.
The Framingham study and the constitution of a restrictive concept of risk factor

One of the first American epidemiological studies of cardiovascular disease, the Framingham Heart Study, is considered to have played a central role in identifying the major risk factors for heart disease and in introducing and diffusing a risk factor approach. Today, a risk factor is usually presented as an individual and biological parameter rather than as a social characteristic, and it is most commonly used as a predictive rather than a causal notion. This paper examines the specific contribution of this prospective study to framing what I call a 'restrictive' concept of risk factor. I show that these characteristics owe much to some peculiarities of this study when compared to other contemporary cohort studies carried out in the USA and in the UK: in particular its conception as a large clinical study, its relationship to American constitutional medicine and the division of work between clinicians and statisticians.
An overview of information goods pricing

Although information economy has been the focus of considerable research, no unified and exhaustive classification model for current pricing methods exists. This work presents a novel unifying pricing framework. Each category in the framework is defined by the structural elements that accounts for its behaviour and particular aims. This work also identifies the implicit joints among categories as the basis for optimising prices (only in terms of different perspectives). The benefits of the unifying framework are that it provides a conceptual abstract model that differentiates between different pricing methods, and positions the future effectual pricing methods.
Medical Center Clinical Rotation for Pharmaceutical Drug Information Professionals

Drug information practitioners can be at a disadvantage in that they do not work directly in patient-care environments. This article describes a clinical rotation program developed to enable Parke-Davis drug information colleagues to experience a contemporary patient care environment at a local medical center. In March 2000, 13 Parke-Davis drug information professionals completed one-day rotations at Morristown Memorial Hospital. The general medicine clinical rotation provided meaningful experience in observing state-of-the-art health care, helped drug information colleagues better relate to the situations that health professional customers face, fostered more effective communication with health care professionals and patients, and provided a better appreciation of patient-care literature and in preparing drug information-medical communications that refer to and discuss patient care situations. Morristown Memorial Hospital has been invited to participate in a rotation program at Parke-Davis.
What value do Smartphones offer business adopters?

This paper explores the value that Smartphones bring to business adopters in Australia, particularly in terms of managing knowledge, and what changes in behaviour they then create. It examines how the level of mobility and flexibility these devices offer can change the way users communicate, do business, interact, plan and manage. A preliminary survey was conducted amongst Australian business adopters of Smartphones, aimed at identifying the type of user they were, what role and industry they were from, and what value Smartphones brought to their working lives. To then validate the results from the survey, and to test any arising theories, a programme of industry interviews were conducted that ventured beyond the opinions of merely the individual user, leveraging the opinions of a number of Australian network carriers, technology providers, application developers, and user organisations.
The use of mobile devices for information sharing in a technology-supported model of care in A&E

Using a case study as an example, this paper illustrates the current model of care in Accident and Emergency (A & E); in particular, the 'cells' in which data/information is stored and how explicit and accessible it is (or is not) to healthcare professionals. It is a model of care which may be summed up as static information/dynamic clinicians. This paper then describes how mobile devices may be used to track patients through an A&E department. From there, a model of care is proposed that has at its core the notion of dynamic information/static clinicians which takes into account the potential and likelihood of such mobile technology being used to support healthcare professionals in the future. It is argued, however, that such 'disruptive technologies' are merely tools at our disposal and that it is human activity which must be foremost when considering how we might work differently ('better') in treating and/or dealing with patients.
Incidental Findings During Routine Antepartum Obstetrical Sonography

The standard for performing an antepartum obstetrical sonogram primarily involves the examination of the fetus; however, both the American Institute of Ultrasound in Medicine (AIUM) and American College of Radiology (ACR) guidelines suggest the evaluation of maternal structures as well. The authors present 35 incidental findings that were discovered on routine antepartum obstetrical sonography. These include abdominal wall, gastrointestinal, reproductive, urinary, and vascular anomalies in the maternal structures. A review of the literature demonstrates that many of these findings have clinical significance, which highlights the wisdom of the AIUM and ACR guidelines, and it also stresses the importance of seeking and reporting them.
Prosthetic rehabilitation of upper limb amputees: a five year review

A review of 55 upper limb amputees, acquired and congenital, referred to a subregional centre for amputee rehabilitation in a five year period is presented. Ninety-six per cent of the amputees were provided with prostheses. Seventy-three per cent of these patients have successfully accepted their prostheses with a minimum follow-up period of two years. The importance of a multidisciplinary approach in providing a comprehensive rehabilitation programme cannot be overemphasized. Patient's views and needs must be at the forefront in formulating the rehabilitation programme. Success of the prostheses should not be determined only on the grounds of active use, as cosmetic replacement may also play a major role in the total rehabilitation of upper limb amputees.
Medication alliance: development and implementation of a mental health staff training program for the enhancement of patient medication adherence

Patient nonadherence to prescribed medications remains a major hurdle in the effective delivery of health care services for people experiencing chronic illnesses. Nonadherence rates are particularly high among those with major mental health problems and account for a significant proportion of hospitalisations due to relapse in conditions previously well-managed by medications. Therefore, interventions to enhance the adherence of patients with mental health disorders should be an essential part of mental health services; however this is not always the case. This thesis involved a series of studies which investigated barriers to the implementation of adherence interventions, in particular, clinician skills, attitudes and knowledge, as well as describing a potential strategy to overcome these barriers. The first study investigated the relationship between the beliefs and knowledge mental health nurses hold about medications and how this influences their self-reported use of strategies to enhance patient adherence to treatment. Participants comprised a convenience sample of 64 mental health nurses who completed questionnaires on their beliefs about medicines, their knowledge of neuroleptic medications and their self-reported difficulties in using commonly cited strategies for enhancing patient adherence. The results indicated that both poorer knowledge and more negative attitudes were associated with greater perceived difficulty in implementing standard adherence strategies. item,
Phytochemistry, pharmacology and medicinal properties of Coriandrum sativum L.

Coriandrum sativum L. commonly known as “Coriander” is an annual herb, indicated for a number of medical properties in traditional medicine. For a long time, C. sativum has been used in traditional medicines as an anti-inflammatory, analgesic, and antibacterial agent. Its essential oil is also used as a natural fragrance with some medicinal properties. C. sativum has recently been shown to have antioxidant, antidiabetic, hepatoprotective, antibacterial, and antifungal activities. Volatile components, flavonoids, and isocoumarins are the main constituents of C. sativum. 2-decenoic acid, E-11-tetradecenoic acid, and capric acid were identified as the major components for C. sativum leaves essential oil. The seed oil contained linalool and geranyl acetate. Due to the easy collection of the plant and being widespread and also remarkable biological activities, this plant has become both food and medicine in many parts of the world. This review presents comprehensive analyzed information on the botanical, chemical, and pharmacological aspects of C. sativum. Key words: Coriandrum sativum, apiaceae, phytochemistry, pharmacology.
A system for assessing cow cleanliness

THE repercussions of modern farming methods and the trend towards intensification are coming under increasing public scrutiny. Following the outbreaks of Escherichia coli 0157 infection in the mid-1990s, abattoirs have imposed standards for the cleanliness of animals submitted for slaughter. It would seem prudent for the dairy industry to remain free from reproach. A high standard of cow cleanliness indicates limited exposure to environmental mastitis pathogens and is elementary to food safety, hygiene and quality assurance schemes. This article describes a numerical scoring system for assessing both cow cleanliness and nutritional status as defined by faecal consistency (which appears to be a dominant factor in determining cow cleanliness). It also suggests a number of practical ways of improving the standard of cow cleanliness.
LOINC®: a universal catalogue of individual clinical observations and uniform representation of enumerated collections

In many areas of practice and research, clinical observations are recorded on data collection forms by asking and answering questions, yet without being represented in accepted terminology standards these results cannot be easily shared among clinical care and research systems. LOINC contains a well-developed model for representing variables, answer lists, and the collections that contain them. We have successfully added many assessments and other collections of variables to LOINC in this model. By creating a uniform representation and distributing it worldwide at no cost, LOINC aims to lower the barriers to interoperability among systems and make this valuable data available across settings when and where it is needed.
Selective sampling-based training schemes for core vector machines

Support vector machines (SVMs) are hyperplane classifiers defined in a kernel induced feature space. The high computational and space requirements for solving the conventional SVM problem prohibit its use in applications involving large datasets. Core vector machine (CVM) is a suitable technique for scaling an SVM for large-scale pattern classification problems. But in applications where the datasets are unbalanced, the performance of CVM is observed to be poor both in terms of generalisation and training time. In such scenarios, the CVM performance highly depends on the orderings of data points belonging to the two classes within the dataset. In this paper, we propose two training schemes which improve the performance of CVM irrespective of the orderings of patterns belonging to different classes within the dataset. These methods employ a selective sampling-based training of CVM using novel kernel-based clustering algorithms. Empirical studies made on several synthetic and real world datasets show that the proposed strategies improve the performance of CVM on large datasets.
A flexible processor for the characteristic 3 ηT pairing

The η T pairing is an efficient method for the calculation of the Tate pairing. In this paper, we describe the hardware implementation of the η T pairing on a supersingular elliptic curve of characteristic 3. All characteristic 3 operations required for the computation of the pairing are outlined in detail. We describe how the required extension field operations can be performed in terms of subfield operations, many of which can be computed in parallel in hardware. The hardware architectures required for pairing computation are also described. An efficient and reconfigurable processor utilising these hardware architectures is presented and discussed. The processor is highly reconfigurable and can easily be tailored for a low area implementation, or for a high throughput implementation or for a desired balance between the two. Results are provided for various configurations of the processor when implemented over the field F397 on an FPGA.
Thermal-aware multifrequency network-on-chip testing using particle swarm optimisation

This paper presents a thermal-aware test scheduling strategy for cores in a network-on-chip NoC design. NoC infrastructure has been utilised to transport test data, thus, avoiding hardware overhead for testing. The scheme is capable of exploiting the capabilities of cores to operate at different frequencies to leverage in testtime and power. Thermal behaviour of the NoC has been modelled using a simple strategy based on core powers and floorplan, thus, avoiding the necessity to perform costly thermal simulations in the schedule generation process. The model has been integrated with a particle swarm optimiser to identify a set of solutions with trade-off in testtime, peak temperature and temperature variance of the NoC. Experimental results show that the testtime results are comparable to the existing power-constrained multifrequency approaches. While the existing approaches produce single result, the proposed approach can produce a range of results. It shows significant improvements in terms of testtime compared to the other reported approaches taking either power or peak temperature as a constraint.
Fast-decodable MIDO codes from non-associative algebras

By defining a multiplication on a direct sum of n copies of a given cyclic division algebra, we obtain new unital non-associative algebras. We employ their left multiplication to construct rate-n and rate-2 fully diverse fast ML-decodable space-time block codes for a Multiple-Input-Double-Output MIDO system. We give examples of fully diverse rate-2 4 × 2, 6 × 2, 8 × 2 and 12 × 2 space-time block codes and of a rate-3 6 × 2 code. All are fast ML-decodable. Our approach generalises the iterated codes in Markin and Oggier.
Coma and Impaired Consciousness: A Clinical Perspective

Part 1 Consciousness, major syndromes and approach: consciousness - definition and context major syndromes of impaired consciousness clinical assessment, investigation and initial management. Part 2 Physical insults and structural lesions causing coma: herniations intracranial hemorrhage trauma neoplasia hypothermia and hyperthermia electrical injuries burn encephalopathy. Part 3 Impaired consciousness and inflammatory conditions: CNS infections other inflammatory diseases affecting CNS - sepsis-associated encephalopathy, collagen-vascular diseases, acute disseminated encephalomyelitis, "toxic encephalopathy" and Reye's syndrome. Part 4 Metabolic, nutritional, ischaemic and toxic encephalopathies: metabolic encephalopathies, mineral and electrolyte disturbances, endocrinopathies, organ failure nutritional disorders ischaemia and anoxia - focal and generalized drugs - poisoning, pharmacologic considerations in impaired consciousness. Part 5 Episodic impairment of consciousness: seizures other causes of episodic loss of consciousness - syncope, transient vascular events, concussion, metabolic and toxic causes, sleep-related disorders, idiopathic recurring stupor, transient globale amnesia, transiently raised intracranial pressure, psychiatric disorders, uncertain aetiologies. Part 6 Impaired consciousness in clinical contexts: the emergency room medical and surgical ICUs the transplant ward the maternity ward neuro-degenerative disorders ethics.
Presidential symposium : Individualized diagnosis for tailored treatment of breast cancer Molecular prediction of the therapeutic response to neoadjuvant chemotherapy in breast cancer

Breast cancer is considered to be relatively sensitive to chemotherapy, and multiple combinations of cytotoxic agents are used as standard therapy. Chemotherapy is applied empirically despite the observation that not all regimens are equally effective across the population of patients. Up to date clinical tests for predicting cancer chemotherapy response are not available, and individual markers have shown little predictive value. A number of microarray studies have demonstrated the use of genomic data, particularly gene expression signatures, as clinical prognostic factors in breast cancer. The identification of patient subpopulations most likely to respond to therapy is a central goal of recent personalized medicine. We have designed experiments to identify gene sets that will predict treatment-specific response in breast cancer. Taken together with our recent trial about the construction of a highthroughput functional screening system for chemo-sensitivity related genes, studies for drug sensitivity will provide rational strategies for establishment of the prediction system with high accuracy, and identification of ideal targets for drug intervention.
Características nutricionales de niños con parálisis cerebral: ARIE - Villa El Salvador, 2004

Objetivos: Determinar la prevalencia y tipos de desnutricion en ninos con paralisis cerebral (PC) e identificar problemas que conducen a ella. Diseno: Estudio clinico descriptivo. Lugar: Centro de Medicina y Rehabilitacion Infantil ARIE, en el distrito de Villa El Salvador. Pacientes: Cincuenta y tres ninos con PC que asistian para su rehabilitacion. Intervenciones: La informacion clinica fue obtenida por entrevista con la madre y para el diagnostico nutricional se utilizo la clasificacion de Waterlow. Para el diagnostico de anemia, se evaluo los valores de hemoglobina y hematocrito. La enteroparasitosis fue diagnosticada por examen directo de heces y examen de Graham, en forma seriada. El procesamiento de informacion y analisis estadistico se realizo utilizando el programa SPSS 11.0. Principales medidas de resultados: Presencia de desnutricion, dificultades para alimentacion, reflujo gastroesofagico, anemia y enteroparasitosis. Resultados: Se encontro desnutricion en 81,1% de ninos, siendo la desnutricion cronica el diagnostico mas frecuente, en 43,5%. Entre los problemas asociados a malnutricion, las dificultades para la alimentacion estuvieron presentes en 94,3% de los ninos y sintomas de reflujo gastroesofagico, en 81,1%. La prevalencia de anemia fue 32,4% y de enteroparasitosis, 54,1%. Conclusiones: Los ninos con paralisis cerebral evaluados presentan una elevada prevalencia de desnutricion, relacionada al hallazgo frecuente de dificultades para la alimentacion, reflujo gastroesofagico y enteroparasitosis. Este grupo de ninos constituye una poblacion de riesgo alto de morbilidad y mortalidad.
HIV/AIDS, the erosion of social capital and the collapse of rural livelihoods in the Nkomazi district of South Africa

HIV/AIDS is a major driver of livelihood insecurity. The AIDS epidemic, through the death or disability of economically productive adults, destabilises and erodes the social networks which sustain the livelihoods of vulnerable households. This paper draws upon research with home-based care workers and family members of 14 households directly affected by HIV/AIDS in the rural district of Nkomazi, South Africa. Through a social capital framework this study reveals the fragile linkages between households and broader kin networks demonstrating the (in)ability of the households to adapt and manage the economic and social impact of the epidemic. The chronic financial burden of the epidemic on poor households compounded by HIV/AIDS-related stigma undermines kinship ties resulting in the extended family becoming more conditional, temporary and at times destructive. The extended family cannot be romanticised as a ‘safety net’ and instead needs to be problematised for its complexities, limitations and constraints while ensuring sufficient external support is provided to sustain the care and support provided by the family and local community.