Miracle-dz/UniFAR-FTUs huggingface dataset:
Experiencias de mujeres frente al cuidado de hijos diagnosticados con hemofilia

Objetivo: describir las experiencias de las mujeres frente al cuidado de sus hijos diagnosticados con hemofilia severa y/o moderada sintomatica que han recibido atencion en el Servicio de Hematologia del Hospital de San Jose (HSJ), Bogota, Colombia. Metodologia: estudio cualitativo de tipo fenomenologico-hermeneutico. La tecnica de recoleccion de datos fue la entrevista a profundidad. La muestra se determino por saturacion de los datos, para la inclusion de los participantes se utilizo muestreo intencional. La informacion se analizo a partir de la propuesta de Strauss y Corbin quienes consideran la codificacion abierta, axial y selectiva. Resultados: participaron en total nueve mujeres cuidadoras de hijos con hemofilia. La informacion fue reducida y analizada para establecer dos categorias: Experiencia de atencion con un hijo hemofilico: desconocimiento, cambios y dificultades, y Trayectoria de la hemofilia en la vida de la mujer: implicaciones derivadas del cuidado. Conclusiones: existe un desconocimiento del sector salud y de la sociedad por ser una enfermedad huerfana dificultando el diagnostico, se evidencia situaciones que incrementan la desigualdad de genero y repercuten negativamente en el desarrollo de la mujer fisica y socialmente.
Aetiology of Depression: Insights from epidemiological and genetic research

markdownabstractThis thesis includes several population-based studies that explore the aetiology of depression, with a specific interest on biological factors, genetics and epigenetics, and physical health factors for depression. Unravelling the aetiology of depression could potentially answer some remaining questions about depression, and finally may explain why we consistently fail to develop effective management and treatment tools for depression. Therefore, this thesis aims to apply advanced epidemiological studies and to extend the existing knowledge on the aetiology of depression. Using population- based data, the studies described in this thesis examine several risk factors and predictors that may enlighten the pathophysiological mechanism that underlie the development of depression. Specifically, Chapter 2 of this thesis presents longitudinal studies that examine the impact of potential biomarkers, such as vitamin D (Chapter 2.1), and inflammatory markers (Chapter 2.2) on the occurrence of depression. Chapter 3 of this thesis presents two studies which apply advanced genetic epidemiological methods to study the genetics of depression. Chapter 4 focuses on the epigenetics of depression and presents the largest epigenome wide association population-based study so far. Moreover, we dedicated a chapter to the impact of physical health conditions such as myocardial infarct on depression (Chapter 5.1) as well as one to the physical consequences of depression such as cognitive decline (Chapter 5.2). Finally, Chapter 6 provides a more general discussion of the main findings in this thesis and addresses several methodological considerations of the studies. Clinical implications of the results in this thesis, and future directions are also presented.
Cystic fibrosis: a model for precision medicine

ABSTRACT Introduction: Cystic Fibrosis is a recessive monogenetic disease caused by mutations in the gene encoding the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), a chloride ion channel expressed by epithelial cells throughout the body. Although it is a multisystem disease, for most patients the pulmonary manifestations of CF account for the major incidences of morbidity and mortality. Areas covered: In this review, the authors discuss new and emerging therapies that target CFTR and describe ex vivo models that have been developed to evaluate the efficacy of precision medicines for people with CF. Expert commentary: Pharmacological and genetic medical technologies to overcome CF have been developed. These treatments are expensive but for people with CF, and especially those with rare CFTR mutations, strategies exist to test appropriate drug doses and combinations thereof ex vivo. The current challenges are to identify the correct CFTR therapy for each patient and make a clinical decision about when that therapy should begin. Notwithstanding the potential effectiveness of these medications, adjunct therapies may also be necessary to treat the infective and inflammatory manifestations of CF lung disease.
MEASURING DISEASE ACTIVITY IN PSORIATIC ARTHRITIS

Psoriatic Arthritis (PsA) is an infl ammatory rheumatic disease predominantly aff ecting joints and skin as well as other organ systems. Th e “treat to target“ concept and the attempt to achieve strict disease control implies the usage of a measuring instruments for the evaluation of disease activity and assessment of treatment eff ectiveness in routine clinical practice as well as in clinical studies. Initially, measuring instruments designed for other diseases, primarily for rheumatoid arthritis (RA) and spondylarthritis (SpA), were used. During the past decade, initiated by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and the Outcome Measures in Rheumatology Clinical Trials (OMERACT), specifi c composite measures of disease activity which include diff erent domains of PsA, have been introduced. Th ere is a tendency to evaluate and categorize disease activity as high, moderate, low, and minimal, while remission is still not well defi ned in respect of the highly heterogeneous clinical presentation and course of the disease. Th e application of specifi c disease activity measures and indexes in routine clinical practice is desirable and necessary, but is diffi cult to achieve due to their complexity and the time required for implementation. Further eff orts by expert groups are focused on a better validation and standardization of instruments for measuring and monitoring PsA activity as well as treatment eff ectiveness in reaching the treatment goal, which is minimal disease activity, with the ultimate goal of achieving and defi ning remission.
On improving the energy efficiency of electric mining excavators

The main directions of increasing the efficiency of using energy resources in mechatronic systems of mining excavators are considered. The main factors affecting the energy efficiency of excavators in quarries are the characteristics of the rock, the quality of the explosive preparation, the organization of the mining and transport complex, the characteristics and condition of the equipment, the geological conditions, the qualifications of the driver, etc. Improving circuit solutions and components allows to change ideological principles of the construction of mechatronic systems and provides the possibility of a significant increase in energy characteristics. The highest energy efficiency is achieved when using AC drives with asynchronous motors for excavators. The current issues of improving the power supply system and reducing the loss of electrical energy in the supply networks are considered.
Double peak emission in lead halide perovskites by self-absorption

Despite the rapidly increasing efficiencies of perovskite solar cells, the optoelectronic properties of this material class are not completely understood. Especially when measured photoluminescence (PL) spectra consist of multiple peaks, their origin is still debated. In this work, we investigate in detail double peak PL spectra of halide perovskite thin films and single crystals with different material compositions. By different optical spectroscopic approaches and quantitative models, we demonstrate that the additional PL peak results from an extensive self-absorption effect, whose impact is intensified by strong internal reflections. This self-absorption accounts for the unusual temperature dependence of the additional PL peak and it implies that absorption until far into the perovskite's Urbach tail is important. The internal reflections entail that even for thin films self-absorption can have a significant contribution to the PL spectrum. Our results allow for a clear assignment of the PL peaks by differentiating between optical effects and electronic transitions, which is a necessary requirement for understanding the optoelectronic properties of halide perovskites.
Linear and nonlinear quantum algorithms made explicit

The promise of technological revolution drives the race to implement quantum algorithms on a real-world quantum computer, but the literature is vast and often-times unwieldy. Where there was little thought before, we concern ourselves with the explicit physical cost of implementing quantum algorithms. Linear quantum algorithms are the standard quantum algorithms that use qubits obeying the linear Schrödinger equation, and comprise optimisation routines faster than their classical counterparts. Nonlinear quantum algorithms are a speculative branch of quantum computing, and assume control of a qubit undergoing nonlinear quantum dynamics. In our analyses of linear quantum algorithms, we introduce a quantum search rubric that standardises quantum circuit notation and makes fundamental gate costs transparent. We give a thorough breakdown of common quantum algorithms into their component parts, and give the explicit cost of each component in terms of fundamental quantum gates. We discuss various methods for producing a quantum superposition state representing all elements of the permutation group on n elements, Sn. Our first method involves amplitude amplification. Combining features of two other methods, by Abrams and Lloyd [1] and Berry et al. [2], we devise six di↵erent algorithms for preparing the quantum superposition state and contrast their resource requirements in terms of qubits and fundamental quantum gates. Through this comparison we determine a new state-of-the-art algorithm for producing a superposition of all permutations. Throughout, we derive explicit gate counts and total qubit count in anticipation that real-world quantum computers might implement some of these methods in the near future. Despite their power, linear quantum algorithms are still insu cient for solving NP–complete and harder problems. Abrams and Lloyd’s nonlinear quantum algorithm purports to solve NP– complete decision problems, but it is not explicit [3]. We expand on their comments and use subsequent work by Childs and Young [4] to design a nonlinear quantum algorithm that solves NP–complete decision problems, exploiting the nonlinearity of the Gross-Pitaevskii equation. Our algorithm is a non-trivial extension of both algorithms, and requires a prolonged mathematical proof of correctness. We describe the explicit gate cost and nonlinear evolution time of each step of the algorithm. Finally, we use our algorithm to solve the NP–complete problem of graph comparison.
Cannabinoids in the Treatment of Parkinson’s Disease

Abstract Due to the changing legal status of medical cannabis and derivatives in numerous countries, this therapeutic option has moved into the field of public debate. Neurologists treating patients with idiopathic Parkinson’s disease are increasingly confronted with questions regarding cannabis as a treatment alternative, especially for levodopa-resistant Parkinson’s symptoms. A number of single case reports and case series suggested improvement of Parkinsonian symptoms after cannabinoid intake, but the small number of available randomized clinical trials failed to reproduce the extent of these findings. Only one trial found a reduction of levodopa-induced dyskinesia with cannabinoid treatment, the remaining three trials showed no effect on Parkinsonian symptoms. This article gives an overview on the effects of cannabis, and reviews experimental and clinical trials studying the effects of cannabinoids in idiopathic Parkinson’s disease.
Reward timing and its expression by inhibitory interneurons in the mouse primary visual cortex

Primary sensory cortex has historically been studied as a low-level feature detector, but has more recently been implicated in many higher-level cognitive functions. For instance, after an animal learns that a light predicts water at a fixed delay, neurons in primary visual cortex (V1) can produce “reward timing activity” (i.e., spike modulation of various forms that relate the interval between the visual stimulus and expected reward). The manner by which V1 produces these representations is unknown. Here, we combine behavior, in vivo electrophysiology, and optogenetics to investigate the characteristics of and circuit mechanisms underlying V1 reward timing in the head-fixed mouse. We find that reward timing activity is present in mouse V1, that inhibitory interneurons participate in reward timing, and that these representations are consistent with a theorized network architecture. Together, these results deepen our understanding of V1 reward timing and the manner by which it is produced.
Costs of internal fixation and arthroplasty for displaced femoral neck fractures

We included in a prospective, randomized study 68 patients aged 70 years or older, with displaced cervical hip fractures. The patients were randomized to internal fixation with hook-pins (36) or primary arthroplasty (32) (total or hemiarthroplasty due to their prefracture status) and followed for 2 years. Patients with rheumatoid arthritis, mental confusion and/or residence in an institution were excluded. The postoperative stay in hospital, rehabilitation wards or nursing homes were recorded as well as complications and the costs of surgery. The aim of this study was to compare the accumulated costs of each method, during the first 2 years after the fracture. In the internal fixation group, 15/36 were considered failures, as compared to 1/32 in the arthroplasty group. As regards primary treatment of the fracture, the durations of surgery and hospital stay were shorter after internal fixation, but the total need for hospitalization/ institutionalizaion was somewhat longer in these patients. The mean 2-year cost for a patient with internal fixation was USD 21,000 and of one with primary arthroplasty USD 15,000. We conclude that primary arthroplasty is a cost-efficient treatment. Considering the very much higher failure rate after internal fixation—leading to increased suffering for these patients—primary arthroplasty stands out as the best method for displaced fractures of the femoral neck.
REKAMAN STASIUN GPS SEBAGAI PENDETEKSI PERGERAKAN TEKTONIK, STUDI KASUS: BENCANA TSUNAMI ACEH 26 DESEMBER 2004

Geographic Position System (GPS) is an electronic instrument that is used to determine the position of coordinates, with the help of the triangulation of satellite signals it can be accurately determined the coordinates of the position. An embedded GPS station is built to track changes in station positions over a period of time. Changes in position over a period of time are calculated using the GPS kinematic method and summed up simply using the GPS velocity method. International GNSS Service (IGS) is a global GPS data provider service with time-per-second densities and millimeter accuracy. During the Aceh tsunami tragedy 26 December 2004 00.58'. 53 "UTC there were 3 GPS stations, each located on a different tectonic plate, the JOGJ station located in Yogyakarta representing the Micro-Sunda plate, the ISSC station located in India representing the Indian plate, and the DGAR station located in the Maldives represents the Eurasian plate as a stable site. The results of data analysis showed that there were 4 phases of tectonic movements during the Aceh tsunami tragedy, anomalous movement phases, pressuring phases, release phases, and stabilization phases. The tectonism study using the GPS station data approach can be used as a parameter to detect plate movement data, especially a great hope for the development of earthquake detection studies. Keywords: GNSS, GPS Kinematic, GPS Velocity, Plate movement, Tsunami trigger Geographic Position System (GPS) adalah suatu intrumen elektronik yang digunakan untuk mengetahui posisi kordinat, dengan bantuan triangulasi sinyal satelit maka dapat ditentukan posisi kordinat secara akurat. Stasiun GPS tertanam dibangun untuk mengetahui perubahan posisi stasiun dalam kurun waktu tertentu. Perubahan posisi dalam kurun waktu tertentu dihitung menggunakan metode GPS kinematic dan disimpulkan secara sederhana menggunakan metode GPS velocity. International GNSS Service (IGS) adalah layanan penyedia data GPS seluruh dunia dengan kerapatan waktu per-detik dan akurasi dalam milimeter. Pada tragedi bencana tsunami Aceh 26 Desember 2004 00.58’. 53” UTC terdapat 3 stasiun GPS yang masing-masing berlokasi pada lempeng tektonik yang berbeda, stasiun JOGJ berlokasi di Yogyakarta mewakili lempeng Micro-Sunda, stasiun ISSC berlokasi di India mewakili lempeng Hindia - Australia, dan stasiun DGAR berlokasi di Maldives mewakili lempeng Eurasia sebagai stable site. Hasil analisa data menunjukan terdapat 4 fase gerakan tektonik selama tragedi tsunami Aceh, fase gerakan anomali, fase penekanan, fase pelepasan dari tekanan, dan fase penstabilan. Studi tektonisme menggunakan pendekatan data stasiun GPS bisa dijadikan parameter data pendeteksi pergerakan lempeng, terutama sebuah harapan besar pengembangan studi pendeteksi gempa bumi. Kata kunci: GNSS, GPS Kinematik, GPS Velocity, Pergerakan lempeng, Pemicu Tsunami
The Association Between Index of Nutritional Quality (INQ) and Gastric Cancer and Evaluation of Nutrient Intakes of Gastric Cancer Patients: A Case-Control Study

Background: Gastric cancer (GC) is the fourth major malignancy and the second leading cause of cancer-related deaths worldwide. Northern and northwestern areas of Iran are among the high risk areas for GC. Studies have shown that dietary components are implicated in the etiology of GC. The index of nutritional quality (INQ) is a method of quantitative and qualitative analysis of single foods, meals, and diets. We aimed to assess the association of INQ with GC, and to evaluate the nutrient intake of GC patients. Methods: The present case-control study included 82 cases and 95 healthy controls attending specialized centers in Tabriz, Iran, from December 2014 to May 2016. INQ scores were computed based on dietary intake assessed using a validated 168-item food frequency questionnaire (FFQ). Logistic regression models were used to estimate multivariable ORs adjusted age, gender, Body Mass Index (BMI), smoking, residency, education, and regular physical activity. Results: After controlling for several covariates, inverse associations were observed between GC risk and INQs of vitamins A, B6, and D (ORvitA = 0.25 (0.06 - 0.98); ORvitB6 = 0.10 (0.04 - 0.28); and ORvitD = 0.14 (0.02 - 0.84)). Cases had higher intake of total fat, saturated fatty acids, beef, lamb meat, salt, and paprika compared to controls. On the other hand, controls had higher intake of vitamin A, vitamin, vitamin B6, copper, poultry, low fat milk, tea, coffee, turmeric, and saffron compared to cases. Conclusions: Subjects who follow a more healthy and nutrient-rich diet, especially in terms of vitamins A, B6, and D, are at lower risk of having GC, compared to those who consume a more unhealthy, nutrient-poor diet.
Effectiveness of an Educational Program on Nurses Knowledge about Chemotherapy Hazards at Al-Habbobi Teaching Hospital in Al-Nasiriyah City

A quasi experimental study design (One-group Pretest-Posttest) study has been carried out at Oncology Center at Al-Habbobi Teaching Hospital in Al-Nasiriyah City from the 26 th of Des. 2018 to 14 th of March 2019 to implement the Effectiveness of an Educational Program on Nurse`s Knowledge about Chemotherapy Hazards, who are working in Oncology Center and to find out the relationship between the nurses’ knowledge towards chemotherapy hazards and their demographic characteristics. To achieve the objectives of the present study, non- random (purposive) sample consists of 47 nurses working in Oncology Center have participated in this study. The data are collected through using constructed questionnaire designed for the purpose of the study, which consists of three parts: The first part is related to the demographic characteristics like nurses’ age, level of education, marital status, years of experience in oncology ward, and years of employment. The questionnaire is used in pretest before conduction of the program, after the application of the program post test which is done after one month and half from first post-test repeated doing of participants of this study.
Psychological Aspects of Obese Primary School Children Pre- and Post-MyBFF@school Intervention Programme: A Pilot Study

Childhood obesity has been seen as a public health challenge in most of the developed and 9 developing countries including Malaysia. This is due to the fact that childhood obesity can 10 result in long term negative effect during adulthood. Thus, early intervention at the primary 11 school stage is essential to prevent obese children from growing up into obese adults. The 12 objective of this study was to analyse the psychological aspects of the obese students during 13 preand post-intervention of the MyBFF@school, a school-based intervention program to 14 combat obesity among children. The respondents comprised of 67 apparently healthy 15 overweight and obese students aged 9-11 years old with BMI above the 85 th percentile 16 according to the WHO BMI chart. Stirling Children’s Wellbeing was used to measure the 17 constructs of positive outlook, positive emotional state and social desirability. Correlation 18 between positive outlook, positive emotional state and social desirability was significantly 19 higher during post-intervention compared to pre-intervention. This finding is crucial as 20 strengthening the wellbeing of the respondents can sustain their involvement in the program. 21 The findings further strengthened the evidence of positive impact of a school-based 22 intervention program which incorporated physical, nutrition and psychological components. 23
Role of C - Reactive protein In Carcinoma Esophagus In Terms Of Survival And Disease Free Progression

Background: Cancer esophagus carries very poor prognosis. Patients usually present at an advanced stage, when curative options are very limited. There is no independent predictive marker, currently available which may indicate the general status of the patient prior to treatment. Keeping in view the poor outcome and great load of this diseases in this part of country, we conducted this study to find out the significance of C - reactive protein levels in our set of patients. Material and methods: A total of 153 patients with histologically confirmed carcinoma esophagus, were enrolled in the study between November 2013 to May 2015.Patient’s eligibility included Squamous cell carcinoma histology, No prior treatment in the form of surgery, chemotherapy or radiotherapy. History of the patient was thoroughly taken to rule out any chronic illness. Besides CBC, biochemistry, imaging modalities used for staging workup, serum C-reactive protein levels were determined in all patients prior to treatment.
Perceptions of Accessibility and Knowledge in Small and Medium Enterprises based on Interest Using e-Banking

- This study was conducted to determine the effect of perceptions of the ease of use of e-banking and knowledge of micro small and medium businesses on the interests of transactions using e-banking. The population in this study were micro small and medium enterprises in Buleleng Regency, Bali and the sample of this study were 120 micro and small enterprises using purposive sampling methods. Data collection techniques by distributing questionnaires directly to respondents. The analysis technique used is descriptive analysis and multiple linear regression analysis. Based on the results of the analysis of research data shows that (1) perceived ease of use has a positive effect on interest in using e-banking, (2) knowledge influences interest in using e-banking, and (3) perception of ease of use and knowledge simultaneously influences interest in using e -banking.