Miracle-dz/UniFAR-FTUs huggingface dataset:
The success of primary angioplasty: Beyond TIMI flow Summary of a presentation held at acute cardiac care meeting in Paris, October 2008

Primary angioplasty is now the preferred reperfusion strategy in patients with acute ST elevation myocardial infarction (STEMI), provided it can be performed within 120 min after first medical contact, according to the most recent version of the ESC guidelines (1). This new guideline, by extending the time window from 90 to 120 min, makes primary angioplasty a serious option for the majority of patients with STEMI in the Western World. Registries have shown that by implementing primary angioplasty as first line therapy, short-term mortality rates declined by 15 to 30% (2).
A distributed control law with guaranteed LQR cost for identical dynamically coupled linear systems

This paper considers a collection of agents per forming a shared task making use of relative information communicated over an information network. A two step design procedure for distributed state feedback control of such systems is proposed. The control law is guaranteed to provide a certain level of performance in terms of an LQR cost at a network level. An analysis of the proposed control law in the presence of delays in the relative information is carried out to obtain a bound on the maximum delay that can be accommodated.
Low-Frequency Noise in Advanced SiGe:C HBTs—Part I: Analysis

In this paper, we present extensive characterization of low-frequency noise in advanced silicon germanium heterojunction bipolar transistors. We demonstrate the extraction methodology of base and collector noise spectral densities for a wide range of transistor geometries. In addition to 1/f noise, generation-recombination (G-R) mechanisms are observed at low bias in the base current noise. Their existence is confirmed by Random Telegraph Signal (RTS) noise measurements. 1/f and G-R components are extracted from the base current noise spectra and their bias dependencies are studied. Finally, base current noise spectral densities measured at the same base current density in different geometries are compared to study the individual contribution of 1/f noise from the periphery as well as the intrinsic device. Part II of this paper will discuss the modeling aspects and noise correlation.
Multicenter Phase II Study of Brequinar Sodium in Patients with Advanced Breast Cancer

In this study, 34 patients with advanced breast cancer were treated with brequinar sodium: 75% of the patients were postmenopausal, and 94% had received chemotherapy previously; 50% had previously received an anthracycline-containing regimen. Brequinar was administered intravenously at a median weekly dose of 1,200 mg/m2. The toxicity was moderate, with 17 patients (50%) experiencing grade 3 or 4 toxicity. There were 33 patients evaluable for response: 4 patients (12%; 95% confidence interval, 3.4–28.2%) achieved partial responses, 10 patients (30%) were stable, and 19 patients (58%) had progressive disease. We conclude that, at this dose and schedule, brequinar has only modest activity in patients with advanced breast cancer.
Proinflammatory cytokines promote glial heme oxygenase‐1 expression and mitochondrial iron deposition: implications for multiple sclerosis

Proinflammatory cytokines, pathological iron deposition, and oxidative stress have been implicated in the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). HO‐1 mRNA levels and mitochondrial uptake of [55Fe]Cl3‐derived iron were measured in rat astroglial cultures exposed to interleukin‐1β (IL‐1β) or tumor necrosis factor‐α (TNF‐α) alone or in combination with the heme oxygenase‐1 (HO‐1) inhibitors, tin mesoporphyrin (SnMP) or dexamthasone (DEX), or interferon β1b (INF‐β). HO‐1 expression in astrocytes was evaluated by immunohistochemical staining of spinal cord tissue derived from MS and control subjects. IL‐1β or TNF‐α promoted sequestration of non‐transferrin‐derived 55Fe by astroglial mitochondria. HO‐1 inhibitors, mitochondrial permeability transition pore (MTP) blockers and antioxidants significantly attenuated cytokine‐related mitochondrial iron sequestration in these cells. IFN‐β decreased HO‐1 expression and mitochondrial iron sequestration in IL‐1β‐ and TNF‐α‐challenged astroglia. The percentage of astrocytes coexpressing HO‐1 in affected spinal cord from MS patients (57.3% ± 12.8%) was significantly greater (p < 0.05) than in normal spinal cord derived from controls subjects (15.4% ± 8.4%). HO‐1 is over‐expressed in MS spinal cord astroglia and may promote mitochondrial iron deposition in MS plaques. In MS, IFN‐β may attenuate glial HO‐1 gene induction and aberrant mitochondrial iron deposition accruing from exposure to proinflammatory cytokines.
Th17 and non-Th17 interleukin-17-expressing cells in chronic lymphocytic leukemia: delineation, distribution, and clinical relevance

Background The levels and clinical relevance of Th17 cells and other interleukin-17-producing cells have not been analyzed in chronic lymphocytic leukemia. The objective of this study was to quantify blood and tissue levels of Th17 and other interleukin-17-producing cells in patients with this disease and correlate blood levels with clinical outcome. Design and Methods Intracellular interleukin-17A was assessed in blood and splenic mononuclear cells from patients with chronic lymphocytic leukemia and healthy subjects using flow cytometry. Interleukin-17A-producing cells were analyzed in formalin-fixed, paraffin-embedded spleen and lymph node sections using immunohistochemistry and immunofluorescence. Results The absolute numbers of Th17 cells in peripheral blood mononuclear cells and the percentages of Th17 cells in spleen cell suspensions were higher in patients with chronic lymphocytic leukemia than in healthy subjects; in six out of eight paired chronic lymphocytic leukemia blood and spleen sample comparisons, Th17 cells were enriched in spleen suspensions. Circulating Th17 levels correlated with better prognostic markers and longer overall survival of the patients. Two “non-Th17” interleukin-17-expressing cells were identified in chronic lymphocytic leukemia spleens: proliferating cells of the granulocytic lineage and mature mast cells. Granulocytes and mast cells in normal spleens did not express interleukin-17. Conversely, both chronic lymphocytic leukemia and healthy lymph nodes contained similar numbers of interleukin-17+ mast cells as well as Th17 cells. Conclusions Th17 cells are elevated in chronic lymphocytic leukemia patients with better prognostic markers and correlate with longer survival. Furthermore, non-Th17 interleukin-17A-expressing cells exist in chronic lymphocytic leukemia spleens as maturing granulocytes and mature mast cells, suggesting that the microenvironmental milieu in leukemic spleens promotes the recruitment and/or expansion of Th17 and other IL-17-expressing cells. The pathophysiology of Th17 and non-Th17-interleukin-producing cells in chronic lymphocytic leukemia and their distributions and roles in this disease merit further study.
Research on Chengdu Vegetables Marketing Based on STP Model

In this paper, we take the consumers in Chengdu vegetables market as samples, in the form of questionnaires and interviews, to study the consumer motivations and psychology, and make market segmentation of consumers. Results show that the consumers in Chengdu vegetables market can be divided into four types: the safety-pursuing type, the convenient and economical type, the family healthy type, and the fashionable type, among which the safety-pursuing type is the largest. Finally, authors put forward some suggestions for Chengdu vegetables market based on current conditions.
Projections to the inferior colliculus from the anteroventral cochlear nucleus in the cat: Possible substrates for binaural interaction

The projections to the inferior colliculus of the cat are shown in autoradiographs after injections of 3H‐amino acids into the anteroventral cochlear nucleus and anterograde axonal transport. Labeled bands of axons are seen in the central nucleus of the inferior colliculus, parallel to the fibrodendritic laminae, and in layers 3 and 4 of the dorsal cortex. A bilateral projection to the lateral, low‐frequency part of the inferior colliculus is observed. In contrast, the more ventromedial, mid‐ and high‐frequency parts receive only a contralateral input. The projections from the cochlear nucleus to both the contralateral midbrain and bilaterally to the superior olivary complex appear to be tonotopically organized. After HRP injections in the inferior colliculus, small numbers of stellate neurons are labeled in the lateral and ventral low‐frequency parts of the anteroventral cochlear nucleus on the ipsilateral side. EM autoradiographs show labeled axonal endings from both sides of the anteroventral cochlear nuclei are present in the same proportion in pars lateralis. Axonal endings from either cochlear nucleus have small, round synaptic vesicles and make asymmetric synaptic contacts on dendrites. Axons from the contralateral side also make axosomatic contacts on large disc‐shaped or stellate cells. Neurons from the ipsilateral anteroventral cochlear nucleus apparently make more synaptic endings per cell as compared to neurons from the contralateral side. Together, bilateral inputs from the anteroventral cochlear nucleus can account for a third of the endings with round synaptic vesicles in pars lateralis of the central nucleus.
Analysis of image-based navigation system for rotorcraft low-altitude flight

Some of the issues in the location of objects using a sequence of images from a passive sensor are examined. Image-object differential equations for a rotorcraft executing an arbitrary maneuver are developed. Assuming an onboard inertial navigation system for rotorcraft and state estimation, this study considers how object location is affected by the choice of Kalman filter estimation technique, the rotorcraft, and the object. Simulation results are presented. >
Protection system studies and tests in point of common coupling of a microgrid to the distribution system

This paper addresses the topic of distributed generation with a focus point of common coupling protection of a microgrid to the distribution system. It describes the regulatory and normative aspects of access to Brazilian distribution system, as well as effects caused by the connection of distributed generation on the network. It also proposes the necessary settings to the protection relay to the point of common coupling and performs tests using a testing equipment of protection relays.
Investigating the Origin of Bright Materials on Vesta: Synthesis, Conclusions, and Implications

The Dawn spacecraft started orbiting the second largest asteroid (4) Vesta in August 2011, revealing the details of its surface at an unprecedented pixel scale as small as approx.70 m in Framing Camera (FC) clear and color filter images and approx.180 m in the Visible and Infrared Spectrometer (VIR) data in its first two science orbits, the Survey Orbit and the High Altitude Mapping Orbit (HAMO) [1]. The surface of Vesta displays the greatest diversity in terms of geology and mineralogy of all asteroids studied in detail [2, 3]. While the albedo of Vesta of approx.0. 38 in the visible wavelengths [4, 5] is one of the highest among all asteroids, the surface of Vesta shows the largest variation of albedos found on a single asteroid, with geometric albedos ranging at least from approx.0. 10 to approx.0. 67 in HAMO images [5]. There are many distinctively bright and dark areas observed on Vesta, associated with various geological features and showing remarkably different forms. Here we report our initial attempt to understand the origin of the areas that are distinctively brighter than their surroundings. The dark materials on Vesta clearly are different in origin from bright materials and are reported in a companion paper [6].
An Improved k-Nearest Neighbor Classification Algorithm Using Shared Nearest Neighbor Similarity

k-Nearest Neighbor (KNN) is one of the most popular algorithms for pattern recognition. Many researchers have found that the KNN classifier may decrease the precision of classification because of the uneven density of t raining samples . In view of the defect, an improved k-nearest neighbor algorithm is presented using shared nearest neighbor similarity which can compute similarity between test samples with nearest neighbor samples. The experiment shows that this method can enhance classification precision compare to the traditional KNN.
Shaping Large Adaptive Reflector Cassegrain configuration using feed-reflector

Three shaping processes were conducted on the LAR system based on a diffraction synthesis technique, using Jacobi-Fourier series to represent the reflector surface. An efficiency of 78.5% was obtained by shaping all three reflectors. The final radiation patterns of each case were compared to those of Grasp8w, and showed an excellent agreement.
Detection of Critical Illness–Related Corticosteroid Insufficiency Using 1 &mgr;g Adrenocorticotropic Hormone Test

ABSTRACT Our objectives were to determine the incidence of critical illness–related corticosteroid insufficiency (CIRCI) in patients with septic shock using a 1 &mgr;g corticotropin (ACTH) test and to describe their clinical outcomes. We retrospectively identified 219 consecutive patients with septic shock assessed for CIRCI with a 1 &mgr;g ACTH test. Standardized testing involved plasma cortisol measurements at baseline (T0) and at 30 min (T30) and 60 min (T60) after ACTH administration. The maximal increase in cortisol (&Dgr; max) was calculated as the difference between T0 and the highest cortisol value at T30 or T60. Critical illness–related corticosteroid insufficiency was defined as &Dgr; max less than 9 &mgr;g/dL after ACTH administration. The mean age of the cohort was 63.0 ± 15.8 years, mean Acute Physiology and Chronic Health Evaluation II score was 26.3 ± 8.1, 85.6% were mechanically ventilated, and the mean number of organ failures was 3.0 ± 1.2. Critical illness–related corticosteroid insufficiency was diagnosed in 70.8% of patients. Twenty-eight-day mortality was highest in patients with baseline cortisol greater than 65 &mgr;g/dL (62.5%) and in those with baseline cortisol 34 &mgr;g/dL or greater and &Dgr; max less than 9 &mgr;g/dL (50.0%). There was no difference in mortality in patients with and without CIRCI (53.9% vs. 36.4%, P = 0.08). Corticosteroids were administered to 69.4% of patients for 5.3 ± 3.6 days. For patients with CIRCI, intensive care unit mortality was similar for those who received corticosteroids compared with those who did not (46.0% vs. 25.0%, P = 0.166). The incidence of CIRCI based on 1 &mgr;g ACTH was high in this septic shock cohort. The highest mortality rates were observed in patients with high baseline cortisol and in those who failed to respond appropriately to ACTH. The administration of corticosteroids was not associated with a reduction in mortality.
Influences of gender on postoperative morphine consumption.

BACKGROUND Gender related differences on morphine consumption during postoperative period following abdominal surgeries. MATERIALS AND METHODS Four hundred and fifty ASA I & II patients of either sex (male =231, female = 219), between the age group of 18-65 y undergoing elective intra abdominal surgeries under general anaesthesia were included for the study. Patients with preexisting pain either acute or chronic preoperatively were excluded from the study. Anaesthesia and analgesia protocol during surgery was standardized. Postoperatively, a loading dose was given to achieve the visual analogue scale (VAS) of ≤30 and subjects were connected to patient control analgesia (PCA) pump containing 0.4 mg/ml of morphine configured to deliver a bolus dose (1 mg) with a 5 min lock-out period. The total analgesic requirements along with VAS (visual analog scale) score were analysed between males and females in the first 24 h postoperatively. All demographic data and between group comparisons were analysed with student t-test. Within group comparisons were done by using one-way-ANOVA test and Tukey's Honestly significant Difference test. RESULTS During the first 24 h, males consumed significantly higher amount of morphine (34.35 ± 6.68 mg) when compared to females (26.78 ± 7.14 mg), p < 0.001. CONCLUSION We conclude that men require more morphine in the postoperative period than women.
Identifying Subjects Who Benefit from Additional Information for Better Prediction of the Outcome Variables

Summary Suppose that we are interested in using new bio‐ or clinical markers, in addition to the conventional markers, to improve prediction or diagnosis of the patient's clinical outcome. The incremental value from the new markers is typically assessed by averaging across patients in the entire study population. However, when measuring the new markers is costly or invasive, an overall improvement does not justify measuring the new markers in all patients. A more practical strategy is to utilize the patient's conventional markers to decide whether the new markers are needed for improving prediction of his/her health outcomes. In this article, we propose inference procedures for the incremental values of new markers across various subgroups of patients classified by the conventional markers. The resulting point and interval estimates can be quite useful for medical decision makers seeking to balance the predictive or diagnostic value of new markers against their associated cost and risk. Our proposals are theoretically justified and illustrated empirically with two real examples.
Pure Red‐Cell Aplasia in Patients with Chronic Lymphocytic Leukemia

Four cases of pure red-cell aplasia (PRCA) in association with chronic lymphocytic leukemia (CLL) are summarized. In addition, all reported cases of CLL-PRCA (27, including our 4 cases) are reviewed to consolidate their clinical features and compare them with those of 26 patients with CLL who were anemic (Stage III) and 52 who were not anemic (Stages O-II). The incidence of PRCA in our patients with CLL is about 6%. Eighty-seven percent of patients with PRCA had B-lymphocyte (B-cell) CLL and 13% had T-lymphocyte (T-cell) CLL. In 4 of 17 patients PRCA was the presenting feature, and in 13 of 17 it developed in patients previously diagnosed as having CLL. In the latter group, the average time from the diagnosis of CLL to the development of PRCA was 50.2 months (range, 1 to 96). The average age at presentation with PRCA was 61.6 years (range, 37 to 79), and the male to female ratio was 1.6 to 3:1. Eighty-one percent had splenomegaly and 65% had lymphadenopathy. The average hematocrit was 17 +/- 3.6% with zero reticulocyte count, and the lymphocyte count was 134 X 10(3)/microliter. Normoblasts were absent in the marrow and lymphocytes constituted 50 to 100% of the marrow cells. In patients with B-cell CLL and those with T-cell CLL, the T cells were found to inhibit the growth of the marrow erythroid progenitors in in vitro cultures. These abnormal T cells (Tr cells) possessed IgG Fc receptors on their surface, which may be responsible for induction of PRCA in these patients. Continued administration of cyclophosphamide and prednisone in moderate doses appears to induce remission from PRCA, but not until the leukemic mass and abnormal Tr cells are markedly reduced. Daily or alternate-day cyclophosphamide administration in small to moderate doses seems to be essential to maintain remission.
Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial

Abstract: HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index–partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.
Implementation of an indoor localization system based on an analysis of the movement of an embedded device. (Mise en oeuvre d'un système de localisation indoor s'appuyant sur une analyse du mouvement d'un terminal embarqué)

Ubiquitous computing refers to providing a global computing service where the user access seamlessly resources. User tracking is one of the most important location-aware applications for maintaining the service even with the users' mobility.Unlike outdoor localization technologies like GPS, indoor localization systems have to encounter many problems such as interferences from external sources, low cost and low latency infrastructure requirements, and high accuracy in a limited space.Our localization approaches associate with technologies that are currently equipped in mobile devices, including NFC technology and inertial sensors and Wireless LAN. The aim of this thesis is to design simple and effective architecture ensuring two requirements: a high accuracy and an adaptation to the multiple scenarios. Therefore, our proposed system does not address to the fingerprint technique and learning machine algorithms. In this thesis, we propose three approaches as follows:- The NFC-tagging approach is an instant on-the-spot localization with almost zero-latency- A combination of accelerometer and magnetometer in the sensors-based approach permits to characterize the user's movement- The signal-strength-based approach using the similarity of radio conditions between the neighbors can update in real time the radio map for long period localization.We analyze the performance of the proposed approaches based on rigorous simulation and experimentation tests. We then implement the proposed approaches in a wireless testbed with Android smartphone. Although the implementation is not a final product, the current application can be used to evaluate the feasibility and the performance of the proposed approaches.
Epstein-Barr Virus Latent Membrane Protein 1 Induces Cellular MicroRNA miR-146a, a Modulator of Lymphocyte Signaling Pathways

ABSTRACT The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is a functional homologue of the tumor necrosis factor receptor family and contributes substantially to the oncogenic potential of EBV through activation of nuclear factor κB (NF-κB). MicroRNAs (miRNAs) are a class of small RNA molecules that are involved in the regulation of cellular processes such as growth, development, and apoptosis and have recently been linked to cancer phenotypes. Through miRNA microarray analysis, we demonstrate that LMP1 dysregulates the expression of several cellular miRNAs, including the most highly regulated of these, miR-146a. Quantitative reverse transcription-PCR analysis confirmed induced expression of miR-146a by LMP1. Analysis of miR-146a expression in EBV latency type III and type I cell lines revealed substantial expression of miR-146a in type III (which express LMP1) but not in type I cell lines. Reporter studies demonstrated that LMP1 induces miR-146a predominantly through two NF-κB binding sites in the miR-146a promoter and identified a role for an Oct-1 site in conferring basal and induced expression. Array analysis of cellular mRNAs expressed in Akata cells transduced with an miR-146a-expressing retrovirus identified genes that are directly or indirectly regulated by miR-146a, including a group of interferon-responsive genes that are inhibited by miR-146a. Since miR-146a is known to be induced by agents that activate the interferon response pathway (including LMP1), these results suggest that miR-146a functions in a negative feedback loop to modulate the intensity and/or duration of the interferon response.