Miracle-dz/UniFAR-FTUs huggingface dataset:
Enamel matrix derivative in intrabony defects: prognostic parameters of clinical and radiographic treatment outcomes.

BACKGROUND The purpose of this retrospective case series study is to identify possible preoperative parameters that could predict postoperative probing depth (PD), clinical attachment level (CAL) gain, or radiographic defect resolution in intrabony defects treated with enamel matrix derivative (EMD). METHODS Sixty-one chronic periodontitis patients, each contributing a 2- or 3-wall intrabony defect treated with EMD, were included. Clinical parameters recorded included the following: PD; CAL; gingival margin position; supracrestal soft tissue (SST); surgical distances of cemento-enamel junction (CEJ) to bone crest (CEJ-BC), CEJ to base of the defect (CEJ-BD), and BC to BD (BC-BD); and depth of 2- and 3-wall components. Radiographic parameters recorded included the following: CEJ-BC, CEJ-BD, BC-BD distances, and radiographic defect angle. Postoperative assessments were performed at 12 months. RESULTS The probability of postoperative PD >4 mm increased 1.6-fold (odds ratio [OR] = 1.6; 95% confidence interval [CI] = 1.2 to 2.3) with each 1-mm baseline PD increase. Baseline PD and surgical CEJ-BD were statistically significant predictors of CAL gain; the greater the baseline PD (OR = 0.5; 95% CI = 0.3 to 0.8) and bone loss (OR = 0.6; 95% CI = 0.3 to 0.9), the less likely that postoperative CAL gain was ≤3 mm. Smoking and SST were significantly associated with defect resolution; failure to achieve ≥65% defect resolution was six-fold greater for smokers (OR = 6.5; 95% CI = 1.7 to 24.5) and almost double (OR = 1.7; 95% CI = 1.1 to 2.8) for each millimeter of SST increase. CONCLUSION In EMD-treated intrabony defects, baseline PD predicts both CAL gain and postoperative PD. Smoking and SST are predictors of defect resolution.
Catálogo de Fraudes da RNP: 7 Anos de Experiência no Tratamento de Fraudes Eletrônicas Brasileiras

The electronic frauds all over the Internet have become a recurring threat to all the people. Everyday, newer and more sophisticated fraud techniques are deployed, causing the less prepared or the less alerted users to be victims of those attacks. The RNP Frauds Catalog of Brazilian Academic and Research Network, created in 2008, consolidates itself as an important repository of brazilian electronic frauds disseminated through e-mail. This paper presents RNP Frauds Catalog, how it works, observed statistics and trends, and future work opportunities that can improve the security of brazilian Internet users. Keywords— Frauds, frauds catalog, eletronic fraud, e-mail, ICCyber.
Drosophila Hox complex downstream targets and the function of homeotic genes

Hox complex genes are key developmental regulators highly conserved throughout evolution. The encoded proteins share a 60‐amino‐acid DNA‐binding motif, the homeodomain, and function as transcription factors to control axial patterning. An important question concerns the nature and function of genes acting downstream of Hox proteins. This review focuses on Drosophila, as little is known about this question in other organisms. The noticeable progress gained in the field during the past few years has significantly improved our current understanding of how Hox genes control diversified morphogenesis. Here we summarise the strategies deployed to identify Hox target genes and discuss how their function contributes to pattern formation and morphogenesis. The regulation of target genes is also considered with special emphasis on the mechanisms underlying the specificity of action of Hox proteins in the whole animal.
Prevention and treatment of thrombotic complications in essential thrombocythaemia: efficacy and safety of aspirin

The efficacy and safety of aspirin in the prevention and treatment of thrombosis in essential thrombocythaemia (ET) was retrospectively analysed in a cohort of 68 ET patients. 41 patients presented with thrombosis, five patients with bleeding; two patients had a paradoxical combination of bleeding and thrombosis at presentation. At presentation, patients with bleeding had significantly higher platelet and leucocyte counts than patients with thrombosis. During long‐term follow‐up the incidence of thrombosis was significantly reduced in patients receiving aspirin, either as monotherapy or in combination with cytoreduction. However, treatment with aspirin (500 mg/d) was associated with an increase in (minor) bleeding complications. In patients receiving aspirin, bleeding occurred particularly at platelet counts exceeding 1000×109/l. The overall 5‐ and 10‐years survival probability was 93% and 84% respectively, indicating that life expectancy in ET is close to normal. Although our data need confirmation in prospective clinical trials, they suggest that aspirin, particularly in lower doses (100 mg/d), may be a safe antithrombotic agent in ET with an acceptable risk for bleeding, if applied to patients with a platelet count <1000×109/l and/or absence of a bleeding history.
Isolation and Posttranscriptional Modification Analysis of Native BC1 RNA from Mouse Brain

We present a simple and general affinity method, based on size fractionation and nucleic acid complementarity, to isolate sufficient amounts of native RNA molecules for further physicochemical studies, such as modification state of nucleotides. In the case presented here, we purified four micrograms of dendritic neuronal BC1 RNA from 130 grams of mouse brain (initially yielding a total of 200 mg RNA). Directly combined liquid chromatography-electrospray ionization mass spectrometry (LC/MS) analysis revealed no base or sugar backbone modifications in native BC1 RNA, despite earlier indications that C-54 could be methylated in vitro (Cm5, position 54).
Pallister–Killian syndrome: tetrasomy of 12pter→12p11.22 in a boy with an analphoid, inverted duplicated marker chromosome

Supernumerary marker chromosomes (SMCs) without detectable alphoid DNA are predicted to have a neocentromere and have been referred to as mitotically stable neocentromere marker chromosomes (NMCs). Here we report the molecular cytogenetic characterization of a new case of Pallister–Killian syndrome (PKS) in a boy with an analphoid, inverted duplicated NMC derived from 12pter→12p11.22 in his fibroblasts by using high‐resolution comparative genetic hybridization (HR‐CGH), multiplex fluorescent in situ hybridization (FISH) and bacterial artificial chromosome (BAC)‐FISH mapping analyses with various alpha‐satellite DNA probes, subtelomere probes and BAC‐DNA probes. Precise identification of SMCs and NMCs is of essential importance in genetic counseling. HR‐CGH is a more informative and often a faster way of precisely identifying the origin of SMCs. This case is the third report of PKS with an NMC containing an inverted duplication of partial 12p with available clinical data. These observations may help to determine the critical region for PKS and the mechanisms leading to the origin of the NMC derived from 12pter→12p11.22 – a region that appears to be susceptible to the formation of neocentromeres. The use of subtelomeric probe PCP12p in buccal cells appears superior to the use of the centromere probe D12Z3 for the diagnosis of the PKS.
Spectra of nilflows

Recently L. Auslander, F. Hahn, and L. Markus [ l ] have examined an important class of dynamical systems, proving the existence of minimal, distal, nonequicontinuous flows on compact nilmanifolds. Their proof is nonconstructive, and gives no information on the measure-theoretic behavior of these flows. Since these flows are defined by the action of one parameter subgroups of the universal covering group of the nilmanifold, it is natural to ask whether the group representation approach of Gelfand-Fomin [3] and Mautner [4] can give more detailed information. The author has shown that this is the case. In fact, a complete qualitative description of the spectra of these flows can now be given, and one can tell precisely which one parameter subgroups give rise to minimal, ergodic flows. Let N be a connected, simply connected, nilpotent Lie group with discrete uniform subgroup D and one parameter subgroup {y t} , •— °° <t< 00. The flow on the nilmanifold M — N/D is defined by <j>t(Dn) — Dnyt. N itself acts transitively on M in the same way, inducing a unitary representation 7—» V(y) of N in the Hubert space of functions on M, square summable with respect to the natural invariant measure. This representation must be expressible as a direct integral of irreducible unitary representations of N. Not all of these have been computed explicitly, but the following qualitative description is sufficient :
Satisfactory Analysis for Cosmetic Product Review Comments

Nowadays, there are various types of cosmetic products and brands. Searching and studying information about cosmetic products from reviews are more important because most people use comments from others to help make purchase decisions. They will have trouble with a lot of cosmetic product reviews. Moreover, it takes a long time to search and read all, and it is difficult to make decisions. Therefore, this paper proposed satisfactory conclusion for cosmetic product review comments to analyze the positive and negative information about various cosmetic products by sentiment analysis. The implemented methods use Naïve Bay Classifier as a machine learning to automatically classify positive or negative comments on cosmetic products. The testing results show that the classification application has high accuracy and precision on both positive and negative comments. However, it is necessary to use positive and negative data in a similar proportion to train the classification application for efficiency result.
Function of p53 in Regulation of TSC Mutant Cell Apoptosis

Abstract : TSC1 and TSC2 are tumor suppressor genes that are mutated in tuberous sclerosis complex (TSC). Mutation in either TSC1 or TSC2 results in a constitutively activation of mammalian target of rapamycin (mTOR) therefore promoting cell growth. mTOR activity is regulated by intracellular signals including growth factors and cellular energy level. Energy starvation such as glucose deprivation inhibits mTOR activity via the activation of TSC2. We have observed that TSC cells are very sensitive to cellular energy starvation. This is because TSC cells fail to stop growth even in the absence of glucose while normal cells will stop grow under glucose starvation. The energy starvation induced cell death is due to apoptosis. P53 is the most frequently mutated human tumor suppressor. It has been reported that p53 is stabilized by AMPK which is activated by energy starvation. The major goal of this proposal is to investigate the functional importance of p53 in energy starvation induced apoptosis in TSC tumor cells. We will test whether p53 phosphorylation and protein levels are accumulated in TSC tumor cells. Furthermore we will investigate the function of TSC1 and TSC2 in p53 regulation. Completion of this proposal will establish a functional relationship between TSC1/TSC2 and p53 tumor suppressors.
Individual differences in response to novelty and the conditioned locomotor effects of nicotine

Rats' locomotor reactivity to an inescapable novel environment has been shown to be correlated with the psychomotor response to many stimulant drugs. However, the effects of nicotine on rats categorized as high responder (HR) or low responder (LR) has yielded inconclusive results. This study examined the effects of nicotine ditartrate in HR and LR rats using both a high (0.8 mg/kg; freebase) and a low dose (0.2 mg/kg; freebase). Male Sprague–Dawley rats were trained for the acquisition of nicotine-induced conditioned hyperactivity. After conditioned-hyperactivity testing, rats underwent extinction training to decrease hyperactivity by administering saline as a substitution for nicotine. Hyperactivity was then reinstated with a nicotine challenge (0.8 or 0.2 mg/kg). Pretreatment with nicotine during acquisition training significantly increased locomotor activity. Similarly, rats that had nicotine repeatedly paired with a distinct environment displayed significant conditioned hyperactivity and reinstatement of nicotine-induced hyperactivity. However, nicotine treatment was not found to differentially affect HR and LR rats. These data suggest that individual differences in response to an inescapable novel environment do not predict nicotine-induced locomotor sensitivity or sensitivity to nicotine-associated drug cues.
Prognostic implication of creatine kinase elevation following elective coronary artery interventions.

OBJECTIVE To determine the prognostic significance of creatine kinase (CK) elevation following elective percutaneous transluminal coronary angioplasty (PTCA). DESIGN Retrospective cohort study. SETTING Tertiary care referral center. SUBJECTS A total of 253 consecutive patients with total CK and CK-MB fraction (CK-MB) elevation (case patients) and 120 patients without CK elevation (controls). Control patients had undergone interventions during the same month and year using the same devices. MAIN OUTCOME MEASURES In-hospital and late cardiac mortality, subsequent myocardial infarction, and the combined end point of cardiac mortality or myocardial infarction. RESULTS Patient groups were similar with respect to age, sex, extent of coronary artery disease, left ventricular function, number of lesions treated by PTCA, and mean duration of follow-up (>3.5 years). Cardiac mortality was significantly greater (P=.02) for patients with CK elevation after PTCA. When patients were categorized according to peak CK elevation, cardiac mortality differed significantly among patient groups (P=.007), with increased cardiac mortality observed for patients with high (>3.0 times normal) and intermediate (1.5 to 3.0 times normal) CK elevations. In multivariate analyses, higher peak CK and lower ejection fraction were the most important predictors of increased cardiac mortality (both, P<.001); the relative risk for cardiac mortality was 1.05 (95% confidence interval, 1.03-1.08) per 100-U/L increment increase in CK. CONCLUSIONS Creatine kinase elevation following elective PTCA is associated with increased late cardiac mortality. This increase in cardiac mortality is independent of clinical variables, severity of heart disease, coronary artery lesion characteristics, interventional devices, and procedural outcomes. Even patients with lesser degrees of CK elevation are at significantly increased risk for late cardiac death.
Evaluation of Matrix9 silicon photomultiplier array for small-animal PET.

PURPOSE The MatrixSL-9-30035-OEM (Matrix9) from SensL is a large-area silicon photomultiplier (SiPM) photodetector module consisting of a 3 × 3 array of 4 × 4 element SiPM arrays (total of 144 SiPM pixels) and incorporates SensL's front-end electronics board and coincidence board. Each SiPM pixel measures 3.16 × 3.16 mm(2) and the total size of the detector head is 47.8 × 46.3 mm(2). Using 8 × 8 polished LSO/LYSO arrays (pitch 1.5 mm) the performance of this detector system (SiPM array and readout electronics) was evaluated with a view for its eventual use in small-animal positron emission tomography (PET). METHODS Measurements of noise, signal, signal-to-noise ratio, energy resolution, flood histogram quality, timing resolution, and array trigger error were obtained at different bias voltages (28.0-32.5 V in 0.5 V intervals) and at different temperatures (5 °C-25 °C in 5 °C degree steps) to find the optimal operating conditions. RESULTS The best measured signal-to-noise ratio and flood histogram quality for 511 keV gamma photons were obtained at a bias voltage of 30.0 V and a temperature of 5 °C. The energy resolution and timing resolution under these conditions were 14.2% ± 0.1% and 4.2 ± 0.1 ns, respectively. The flood histograms show that all the crystals in the 1.5 mm pitch LSO array can be clearly identified and that smaller crystal pitches can also be resolved. Flood histogram quality was also calculated using different center of gravity based positioning algorithms. Improved and more robust results were achieved using the local 9 pixels for positioning along with an energy offset calibration. To evaluate the front-end detector readout, and multiplexing efficiency, an array trigger error metric is introduced and measured at different lower energy thresholds. Using a lower energy threshold greater than 150 keV effectively eliminates any mispositioning between SiPM arrays. CONCLUSIONS In summary, the Matrix9 detector system can resolve high-resolution scintillator arrays common in small-animal PET with adequate energy resolution and timing resolution over a large detector area. The modular design of the Matrix9 detector allows it to be used as a building block for simple, low channel-count, yet high performance, small animal PET or PET/MRI systems.
Klebsiella pneumoniae in Breast Milk-A Cause of Sepsis in Neonate

Objective: The aim of the analysis was to present two cases of a late onset sepsis (LOS) caused by Klebsiella pneumoniae (KLE) recognized in prematurely delivered siblings, born within the interval of one year. Study Design and Result: It was a retrospective study. The first child was born after 32 weeks of pregnancy and the gestational age of the second infant was 29 weeks of pregnancy and died in the course of sepsis without positive blood culture examination. In the second child, sepsis with the same clinical signs was diagnosed, the strains of KLE were isolated from the blood and from the mother's breast milk: the strains were identical, confirmed with PFGE. Conclusion: Presented results suggest that the source of infections in both siblings was contaminated breast milk. The targeted therapy used in the mother allowed breastfeeding the child.
The Swedish Knee Arthroplasty Register. Validity and Outcome.

The Swedish Knee Arthroplasty Register (SKAR) was initiated in 1975 to prospectively follow patients operated on with knee arthroplasty. With revisions utilized as the end-point in survival analyses, it is of importance that all revisions of included patients are reported. To validate if revision status was correctly recorded, a postal survey was made among all living patients, registered as operated during 1975-1995. 1.7% of the responding knees were found to have been revised but not reported to the register, or about one fifth of all revisions. We further investigated if the missing revisions could have been localized by comparison of the SKAR and a database run by the health authorities (PAS), and found that 84% would have been revealed by this method. The SKAR was subsequently uptated with respect to the missing revisions. The survey also included a short inquiry regarding patient satisfaction. 81% were satisfied or very satisfied, 11% uncertain and 8% unsatisfied. The satisfaction rate was relatively constant regardless of the time passed since the primary operation. In revised cases 22% of patients were unsatisfied. To evaluate the economical effect of using a total knee (TKA) instead of a unicompartmental knee (UKA), for uni- compartmental arthrosis, we compared the length of hospital stay, cost of implants and rate of revision. The TKA was more expensive and had a lower rate of revisions. However, the UKA saved more money than the cost generated by the increased number of revisions and it had a lower rate of serious complications. Investigating if the volume of surgery affected the risk of revision after UKA, we found that performing few operations was associated with an increased risk. By combining data from the national census register and the SKAR we determined the age specific incidence of knee arthroplasty. We found that the past changes in the age profile of the population only explained a small part of the observed increase in surgery while future changes could be expected to increase the demand for knee arthroplasty by at least 1%/ year. While 5 years have passed since the last major report from the SKAR regarding general outcome, the number of operations has almost doubled. With the register validated and updated with respect to revisions, we report on general demographic and epidemiological outcome with special emphasis on for the most recent 10-year period. The update of the register had led to a general increase in revision rate but otherwise the conclusions did not differ from those drawn from the register in recent years, the results after knee arthroplasty being affected by factors related to patients, material, methods and time of operation. (Less)
The Potential Effects of Caffeinated Beverages on Insulin Sensitivity

ABSTRACT Caffeinated beverages, most commonly tea and coffee, may have important effects on insulin regulation that may give their consumption an important role among nutritional factors in the development of diseases of glucose and insulin metabolism, such as diabetes and atherosclerotic vascular diseases. These beverages include compounds that may have contradictory effects on insulin and glucose: Caffeine impairs insulin sensitivity, but polyphenolic molecules within tea, coffee, and cocoa augment the effects of insulin. In addition, epidemiologic associations exist between greater consumption of such beverages and lower risk of diabetes. The beneficial effects of such beverages might be enhanced by changing the process of their preparation and substitution of other substances commonly added to caffeinated beverages that impair the effect of insulin, such as sugar or milk.
[Treatment of choleriform diarrhea during pregnancy].

A retrospective review was conducted of the clinical histories of 43 pregnant women treated for acute diarrheal disease in the emergency ward of the María Auxiliadora Departmental Hospital (HADMA) in Lima, Peru, and 32 of the histories were selected for this study. These 32 patients had been admitted to the cholera treatment unit (CTU) of the HADMA for acute choleraic diarrhea with moderate or severe dehydration. The objective was to analyze the clinical evolution of the patients, their response to isotonic rehydration therapy (0.9% saline solution), and the consequences for their pregnancies. The following variables were examined: age; trimester of pregnancy; heart rate and mean blood pressure (MBP) at admission; number of hours since last normal urination; duration of diarrhea; degree of dehydration; volume of diarrhea and vomiting; volume of saline solution administered in the first 2 hours and in total; volume of multi-electrolyte solution (MES) or oral rehydration salts (ORS) administered from the second to the sixth hour and in total; and hours between admission to the emergency ward and transfer to the cholera treatment unit (EME/CTU). Logistic regression analysis revealed a direct and statistically significant correlation between the time of recovery of diuresis and the EME/CTU (P = 0.001; r = 0.65), as well as between time of recovery of diuresis and the volume of diarrhea in the first 4 hours. (ABSTRACT TRUNCATED AT 250 WORDS)
On noise and the performance benefit of nonblocking collectives

Relaxed synchronization offers the potential for maintaining application scalability, by allowing many processes to make independent progress when some processes suffer delays. Yet the benefits of this approach for important parallel workloads have not been investigated in detail. In this paper, we use a validated simulation approach to explore the noise-mitigation effects of idealized nonblocking collectives, in workloads where these collectives are a major contributor to total execution time. Although nonblocking collectives are unlikely to provide significant noise mitigation to applications in the low operating system noise environments expected in next-generation high-performance computing systems, we show that they can potentially improve application runtime with respect to other noise types.