Miracle-dz/UniFAR-FTUs huggingface dataset:
Leadership as the effective tool in the organizational management system

There are constant complications in the structure of the organization and activity of people during historical developments of society. The similar movement is carried out in the form which represents the formation of new kinds of activity and their allocation as a result of division of the social activities accompanied with growth of its productive force. The history of all human societies was subordinated to the purposes of survival of the certain individual and social community. People live and work in common, therefore their activity due to its public character needs to be managed for giving purposeful implementation and to achieve a final result. The management mechanism of primitive community consisting of the elders, the leader, council and some other institutes of management and influence (divine laws, customs, traditions, rituals) is much simpler than the management mechanism of a modern society. The structure and functions of the modern state are incomparable on complexity with management mechanisms of primitive tribes. The most widespread interactions – between the heads and their subordinates assume hierarchy of the official statuses and promote formation of leadership in the administrative relations. Nowadays the heads have to possess not only professional characteristics but also many personal qualities which promote an effective management. One of such qualities is leadership. This paper contemplates on the leadership as the effective tool of in managing complex organizational systems.
Accuracy of intraocular lens power calculation in pediatric cataracts with less than a 20 mm axial length of the eye.

INTRODUCTION Selection of an appropriately-powered IOL is a complex issue, especially in eyes with an axial length of less than 20 mm in pediatric cataract. OBJECTIVE To assess the accuracy of IOL power calculation formulae in pediatric cataracts in eyes with an axial length of less than 20 mm. MATERIALS AND METHODS The records of children less than 15 years old with congenital cataract who had undergone primary IOL implantation were analyzed. MAIN OUTCOME MEASURES The variables studied were axial length, keratometric values and the prediction error. The data were analyzed for prediction error determination using the SRK II, SRK T, Holladay 1 and Hoffer Q IOL power calculation formulae. The formula that gave the best prediction error was identified. RESULTS Twenty-eight eyes of 19 children were included in the study. The absolute prediction error was found to be 1.84 ± 2.09 diopters (D) with SRK II, 2.93±3.55D with SRK T, 3.63±4.06D with Holladay 1, and 4.83±5.02D with Hoffer Q. The number of eyes with the absolute prediction error within 0.5 D was 6 (21.42%) with SRK II, 4 (14.28%) with SRK T, 1 (3.57%) with Holladay 1, and 3 (10.71%) with Hoffer Q. The absolute prediction error with SRK II formula was significantly better than that with other formulae (P less than .001). The axial length influenced the absolute prediction error with Hoffer Q formula (P = 0.04). The mean keratometry influenced the prediction error with SRK T formula (P = 0.02), Holladay 1 formula (P = 0.02) and Hoffer Q formula (P = 0.02). CONCLUSION Although the absolute prediction error tends to remain high with all the present IOL power calculation formulae, SRK II was the most predictable formula in this study.
INVITED COMMENTARIES Death in Pediatric Intensive Care Unit: Not for Children With Acute Pancreatitis

I n this issue of the Journal of Pediatric Gastroenterology and Nutrition, Goday et al (1) report on the outcomes of children with acute pancreatitis discharged from the pediatric intensive care units (PICUs) using a multicenter database (Virtual PICU Systems [VPS]). They found that mortality from acute pancreatitis was rare compared with the adult series. Studies estimate the annual incidence of pediatric acute pancreatitis similar to the rates reported in adults (2). Most children with acute pancreatitis have a mild course (3,4). In a subset of patients, the disease becomes severe with the emergence of local and systemic complications (ie, peripancreatic fluid collections and single or multiple organ failure) (5). Adults who develop persistent organ failure and/or infected pancreatic necrosis are at increased risk of death from acute pancreatitis (35%–50%) (6). The overall outcomes are better in children compared with adults: the death rate from acute pancreatitis is <10% in children and associated with severe disease and presence of systemic complications (3,4,7). In children, the etiologies of acute pancreatitis are diverse. Biliary/obstructive factors, medications, and multisystem diseases are the main causes of acute pancreatitis in the pediatric age group (3,4,8). Goday et al (1) focused their questions on the outcome of children admitted to PICU with acute pancreatitis, utilizing VPS. VPS is a clinical database with>110 hospital members who collect information from all PICU admissions, including demographics, discharge diagnoses (primary and secondary), interventions, severity of illness scores, and mortality data. The authors used 2 severity of illness scores: Pediatric Index of Mortality-2 (PIM2, based on data obtained at the time of PICU admission) and PRISM III scores (based on data obtained during the first 24 hours of PICU admission). Other outcome measures included PICU length of stay, incidence and duration of mechanical ventilation, and mortality rate. Of the 360,612 PICU discharges over a 4 year-period, they
Construction of Refined Protein Interaction Network for Predicting Essential Proteins

Identification of essential proteins based on protein interaction network (PIN) is a very important and hot topic in the post genome era. Up to now, a number of network-based essential protein discovery methods have been proposed. Generally, a static protein interaction network was constructed by using the protein-protein interactions obtained from different experiments or databases. Unfortunately, most of the network-based essential protein discovery methods are sensitive to the reliability of the constructed PIN. In this paper, we propose a new method for constructing refined PIN by using gene expression profiles and subcellular location information. The basic idea behind refining the PIN is that two proteins should have higher possibility to physically interact with each other if they appear together at the same subcellular location and are active together at least at a time point in the cell cycle. The original static PIN is denoted by S-PIN while the final PIN refined by our method is denoted by TS-PIN. To evaluate whether the constructed TS-PIN is more suitable to be used in the identification of essential proteins, 10 network-based essential protein discovery methods (DC, EC, SC, BC, CC, IC, LAC, NC, BN, and DMNC) are applied on it to identify essential proteins. A comparison of TS-PIN and two other networks: S-PIN and NF-APIN (a noise-filtered active PIN constructed by using gene expression data and S-PIN) is implemented on the prediction of essential proteins by using these ten network-based methods. The comparison results show that all of the 10 network-based methods achieve better results when being applied on TS-PIN than that being applied on S-PIN and NF-APIN.
Étude expérimentale de l'origine du bruit émis par les flammes de chalumeaux

Le bruit emis par les flammes de chalumeaux depasse couramment 85 dBa. Son origine et les moyens a mettre en oeuvre pour le reduire sont etudies dans cette these. La flamme d'un chalumeau alimente en propane-oxygene est caracterisee par une analyse quantitative de sa chimiluminescence, sa pression acoustique en champ libre, les vitesses d'ecoulement et un traitement d'images numeriques. La turbulence de l'ecoulement est beaucoup trop faible pour expliquer l'intensite du bruit. Deux mecanismes d'emission sonore originaux sont identifies : les variations de surface de flamme liees a l'instabilite de darrieus-landau et la combustion quasi-homogene de petits volumes de gaz frais formes lors du detachement de poches en bout de flamme. L'instabilite de darrieus-landau dans cette configuration de flamme accrochee est etudiee sur un bruleur modele. Une flamme laminaire est stabilisee sur un bruleur a fente et un champ electrique cree des perturbations d'amplitude et de longueur d'onde controlees a sa base. Ces perturbations sont convectees a la vitesse de l'ecoulement et leur amplitude croit exponentiellement. La dependance du taux de croissance temporel en fonction du nombre d'onde est correctement predite par l'etude de stabilite lineaire des flammes planes libres. Les nombres de Markstein fournis indirectement par cette analyse diminuent avec la richesse et augmentent avec la concentration en oxygene. Le seuil d'apparition des poches et la variation du bruit associent leur formation en fonction de l'amplitude des structures sont correctement predits par un modele geometrique simple. Au terme de cette etude, nous avons obtenu une reduction de 20 db du bruit du chalumeau en retardant le declenchement de l'instabilite de darrieus-landau (brevete).
Error-prediction analyses in 1X, 2X and 3Xnm NAND flash memories for system-level reliability improvement of solid-state drives (SSDs)

The system-level reliability of solid-state drives (SSDs) is investigated with 1X, 2X and 3Xnm NAND flash memories. The reliability degradation of NAND with scaling is an serious issue. Advanced ECC with signal processing such as error-prediction low-density parity-check (EP-LDPC) and error recovery (ER) scheme will be needed in the future SSDs. In this paper, the NAND reliability information used for EP-LDPC and ER is examined. System-level reliability with conventional ECC and EP-LDPC is measured.
Vitamin Para-Aminobenzoic Acid (PABA) Controls Generation of Nitric Oxide (NO) In Vitro and its Biological Functions in the Bacterial Cells

Nitric oxide (NO) serves either a universal signaling molecule or extremely toxic agent, depending on the dose. Up to date there have been a very limited number of natural compounds serving as effective regulators of NO signaling and toxic potencies. NO acts in concert with H2S to coordinate cell responses; however, how exactly this interaction is achieved is not known. Both agents have an effect on the accumulation of both reactive chemical species, ROS and RNS and can give rise to other reactive species. Para-aminobenzoic acid (PABA) is an essential metabolite for certain organisms. Once considered a vitamin, PABA, functions as an effective inhibitor of inducible SOS DNA repair processes in E. coli. In the present study we focus on the genetic and physiological evidence in favor of interference of NO-donors and PABA in bacterial cells with DNA repair gene expression and biofilm formation, depending on the rate of NOdonating in vitro and intracellular ROS/RNS accumulation in the cells. The crystalline dinitrosyl iron complexes (NO- 29 and NO-33) with thiourea as the ligands and 3 crystalline tetranitrosyl iron complexes with thiosulfate (TNICthio) - and with sulfur-containing aliphatic ligands – cysteamine and penicillamine were studied first as the NO-donors in pure solutions and in the combination with PABA. In E. coli cells with the combined action of PABA (0.01-5 mM) with nitric oxide donors we observed an inhibition of NO-signaling potency in the SOS (sfiA gene)- and the SoxRS (soxS gene) DNA repair pathway up to 3.5 fold, depending on the dose of PABA. PABA tested at 0.5 mM afforded 24% protection against the level of biofilm formation induced by TNICthio. Using the antioxidant-capacity assay, we observed a many-fold decrease in the ROS/RNS level production in the samples of E. coli cells with PABA and NO-donor-TNICthio.
Factors Affecting Constraints and Oppportunities for Women Entrepreneurs in UAE - An Overview.

Women entrepreneurs increasingly contribute to the economic growth and creation of job opportunities today. Despite the opportunities that are present in countries such as the UAE, some women are still unable to pursue their entrepreneurial motives, due to the constraints that they face. The aim of the paper is to provide an overview of various factors affecting the constraints and opportunities for women entrepreneurs in UAE. While existing literature describes some studies unfolding the wave of entrepreneurship among women, the ones focusing specifically on UAE cluster are even fewer. The paper acknowledges the various efforts made the governments to promote and encourage women entrepreneurship, and highlights some of the barriers for women entrepreneurship as well as giving recommendation to address those gaps. The article makes use previous research conducted on the topic and acts as a spring board for further empirical research.
Linear time computable problems and first-order descriptions

It is well known that every algorithmic problem definable by a formula of first-order logic can be solved in polynomial time, since all these problems are in L (see Aho and Ullman (1979) and Immerman (1987)). Using an old technique of Hanf (Hanf 1965) and other techniques developed to prove the decidability of formal theories in mathematical logic, it is shown that an arbitrary FO-problem over relational structures of bounded degree can be solved in linear time.
Age Prediction in the Adult Based on the Pulp-to-Tooth Ratio in Lower Third Molars: A Cone-beam CT Study

Estimation of age-at-death is an integral part of the identification process of individuals in many forensic odontology cases where their identity cannot be determined by visualization or other ways. Dental age estimation in the adult is more chal lenging as most of the dentition is completely developed by 18 years of age. This study employs a mesio-distal (MD) pulp-to-tooth ratio ta ken the neck of lower third molars (LM3) to provide an estimation of age at the time of radiographic imaging based on the well-known fa ct that pulp volume tends to decrease with advancing age due to continued apposition of secondary dentine throughout adulthood. A total of 1 55 C nebeam computed tomography (CBCT) radiographs of LM3s for a random sample of 155 Jordanian Arabs (80 females, 75 males; age range = 18-58 years, mean age= 28.2 years, SD =10.0 years) were used. Both pulp and tooth MD diameters were measured at the neck. MD pu lp-totooth ratios for LM3s were linearly regressed against age. Statistically significant negative association was found between an individual’s age at the time of imaging and the MD pulp-to-tooth ratio taken at the neck. Specifically, the strength of the association is r = -0.361, which means only 13.0 % of the variation in age can be explained by the MD pulp-to-tooth ratio taken at the neck. Therefore, it was c oncluded that MD pulp-to-tooth ratio taken at the neck of LM3s is not a reliable predictor of chronological age in adults, possibly due to th e large variation in the timing of LM3 development.
Editorial : Innovation in Living Labs

Ratatie 22, 01300 Vantaa, Finland Phone +358 (0)9 8868 7150 Fax +358 (0)9 8868 7200 firstname.surname@laurea.fi www.laurea.fi Business ID 1046216-1 Domicile Vantaa PLEASE NOTE! THIS IS SELF‐ARCHIVED VERSION OF THE ORIGINAL ARTICLE To cite this Article: McPhee, C. , Leminen, S. , Westerlund, M. , Schuurman, D. , & Ballon, P. (2017) Editorial: Innovation in Living Labs (February 2017). Technology Innovation Management Review, 7(2): 3‐6. URL: http://timreview.ca/article/1052 CC BY 3.0
GReMLIN: A Graph Mining Strategy to Infer Protein-Ligand Interaction Patterns

Interactions between proteins and ligands are relevant in many biological processes. In the last years, such interactions have gained even more attention as the comprehension of protein-ligand molecular recognition is an important step to ligand prediction, target identificantion, and drug design, among others. This article presents GReMLIN (Graph Mining strategy to infer protein-Ligand INteraction patterns), a strategy to search for conserved protein-ligand interactions in a set of related proteins, based on frequent subgraph mining, that is able to perceive structural arrangements relevant for protein-ligand interaction. When compared to experimentally determined interactions, our in silico strategy was able to find many of relevant binding site residues/atoms for CDK2 and active site residues/atoms for Ricin.
Demonstration of KIOSK data downloading system at 300 GHz based on InP MMICs

In this report, we briefly presented the concept of the KIOSK data downloading system at 300-GHz and MMICs for the transmitter based on the state-of-art InP HEMTs technology. Recently, we have achieved the 20-Gbps error free data transmission (BER <; 10 -9) over 1-meter distance with the MMICs in well controlled experimental environment. Those results will be presented in future. In addition, concept and consideration for the small package for receiver modules was presented. Based on the standard LTCC technologies, we experimentally demonstrated the broadband high gain antenna with the volume less than 0.1 cc. This work was supported in part by the research and development program on Multi-tens gigabit wireless communication technology at sub-terahertz frequencies of the Ministry of Internal Affairs and Communications, Japan.
Recent developments and the future of health planning in African countries

The health status in the African Region has increased in the past 15 years, though still faced with many challenges and threats. To move forward, improvements in the health planning process are needed as part of the effort to strengthen health governance. The history of health planning is rich in effort, and shows evolution with the prevailing paradigm of health management at each point in time. As a result, with the advent of SDGs as health security preparedness needs, it is imperative that the heath planning process be realigned with the governance needs and expectations of countries. Recognizing persisting planning challenges relating to poor policy dialogues, uneven prioritization capacity, rigid processes, poor linkages of planning tools and with inter-sectoral actions and implementation guidance, the WHO regional office is proposing adoption of a comprehensive planning framework and process that takes cognizance of these challenges. It defines the respective tools and processes needed for effective health planning, including their relationships and linkages. Adoption of a comprehensive planning process will support attainment of health objectives, and guide movement towards SDGs in countries. Appropriate tools, and procedures will be developed in line with the comprehensive planning process to facilitate its application in countries.
Phospholipase-induced modulation of dolichyl-phosphomannose synthase activity.

Rat liver dolichyl-phosphomannose synthase is optimally active when the enzyme is reconstituted with lipids that prefer a nonlamellar macroscopic organization in isolation, such as phosphatidylethanolamine (PE), but the enzyme is only negligibly active in the presence of lipids that normally form stable bilayers, such as phosphatidylcholine (PC) [Jensen, J.W. , & Schutzbach, J.S. (1985) Eur. J. Biochem. 153, 41-48]. We now report that the activity of the synthase can be modulated by incorporating diacylglycerol and lysophosphatidylcholine into the lipid matrix. Enzyme activity in PC bilayers was stimulated by the presence of diacylglycerol, a lipid that has a conical dynamic molecular shape and disrupts bilayer stability. In PC/diacylglycerol mixtures the apparent Km for dolichyl-P was 30-fold lower than the apparent Km for the polyprenol acceptor in PC membranes. Enzyme activity was also stimulated when diacylglycerol was generated in situ by incubation of PC vesicles with phospholipase C. In contrast, the activity of enzyme reconstituted in PE dispersions, or in PE/PC bilayers, was markedly inhibited by the presence of lysophospholipids. Enzyme activity was also reduced by the in situ generation of lysophospholipids in PE/PC vesicles by incubation with phospholipase A2. Since lysophospholipids and diacylglycerols arise in vivo as products of phospholipid metabolism, modulation of enzyme activity by these compounds may represent a potential regulatory mechanism for the synthesis of oligosaccharide lipids.
Value Creation: An Integrative Strategy for Performance Improvement

48 KOKKUVÕTE (ESTONIAN TRANSLATION OF ABSTRACT) . 49 ELULOOKIRJELDUS . 50 CURRICULUM VITAE . 58 APPENDIX 1 . 69 APPENDIX 2 . 79 APPENDIX 3 . 101
PUVA therapy.

PUVA is an acronym for psoralen plus ultraviolet-A radiation. This form of photochemical therapy is commonly used in the treatment of psoriasis and vitiligo, but it is also beneficial in other dermatologic diseases. An understanding of psoralen's mechanism of action and the unique properties of the various psoralen preparations is important in ensuring optimal results with this therapy.
ISOLATION AND CHARACTERIZATION OF PSEUDOMONAS FLUORESCENS FROM RICE FIELDS

In the recent times, there has been a reversed interest in the search of plant growth promoting rhizobacteria (PGPR) for sustainable crop production. Rice is an economically important food crop, which is subjected to infection by a host of fungal, viral and bacterial pathogens. Thirty five (Pf1.Pf35) isolates of Pseudomonas fluorescens were isolated from the rizosphere of rice fields. These were tested against S. oryzae in dual culture method. Among these, seven (Pf4, Pf6, Pf8, Pf11, Pf13, Pf15 and Pf20) isolates were showed bright fluorescence under UV light were further tested. All the cultural and biochemical studies confirmed them to be P. fluorescens. The isolates also showed positive response for siderophore production and plant growth promoting activity on rice cultivar ADT 36. Among these isolates Pf 13 and Pf 04 showing on par root length and shoot length. Both the Pf13 and Pf04 isolates were found significantly superior than other isolates in increasing the shoot length and root length over control. The isolates Pf13 was recorded high vigor index (3830) followed by Pf04 (3648). The least vigor index was recorded by Pf08 (2631).
Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer.

RATIONALE The development of lung cancer (LC) is accompanied by field changes in the airway mucosa that may have prognostic importance. OBJECTIVES To compare patients with prevalent LC to control subjects regarding their histologic dysplasia scores and chromosomal aneusomy as measured by fluorescence in situ hybridization (FISH). METHODS The most advanced bronchial histology lesion was assessed from each of 44 LC cases and 90 cancer-free control subjects using a four-color FISH probe set encompassing the chromosome 6 centromere, 5p15.2, 7p12 (epidermal growth factor receptor), and 8q24 v-myc myelocytomatosis viral oncogene homolog (MYC) sequences. Histology grades were coded as dysplasia (moderate or severe) or carcinoma in situ (CIS). MEASUREMENTS AND MAIN RESULTS CIS was the highest histologic grade for 32 subjects, and dysplasia was the highest grade for 102 subjects (54 moderate, 48 severe). Chromosomal aneusomy was seen in 64% of the LC cases, but in only 31% of the control subjects (odds ratio [OR], 4.68; 95% confidence interval [CI]. 1.97-11.04). Among those with any level of dysplasia, the OR for positive FISH and LC was 2.28 (95% CI, 0.75-6.86). Among those with CIS, the OR for positive FISH and LC was 5.84 (95% CI, 1.31-26.01). CONCLUSIONS Chromosomal aneusomy is associated with LC. Prospective examination of aneusomy as a precursor lesion that predicts LC is needed.