Miracle-dz/UniFAR-FTUs huggingface dataset:
Modulation of amyloid‐β‐induced and age‐associated changes in rat hippocampus by eicosapentaenoic acid

The age‐related deficit in long‐term potentiation (LTP) in the dentate gyrus is positively correlated with hippocampal concentration of the pro‐inflammatory cytokine, interleukin‐1β (IL‐1β). Previous evidence also indicates that the inhibition of LTP induced by intracerebroventricular injection of amyloid‐β1–40 (Aβ) is accompanied by increased hippocampal IL‐1β concentration and IL‐1β‐stimulated signalling, specifically activation of the stress‐activated protein kinase, c‐jun N‐terminal kinase (JNK). We considered that the underlying age‐related neuroinflammation may render older rats more susceptible to Aβ administration and, to investigate this, young, middle‐aged and aged rats were injected intracerebroventricularly with Aβ or vehicle. Hippocampal IL‐1β concentration, JNK phosphorylation, expression of the putative Aβ receptor, Receptor for advanced glycation end products (RAGE) and the microglial cell surface marker, CD40 were assessed. We report that Aβ inhibited LTP in a concentration‐dependent manner in young rats and that this was accompanied by concentration‐dependent increases in hippocampal IL‐1β and expression of phosphorylated JNK, RAGE and CD40. While 20 μmol/L Aβ exerted no significant effect on LTP in young rats, it inhibited LTP in middle‐aged and aged rats and the increased vulnerability of aged rats was associated with increased IL‐1β concentration. Treatment of rats with eicosapentaenoic acid attenuated the inhibitory effect of 60 μmol/L Aβ on LTP in young rats and the effect of 20 μmol/L Aβ in middle‐aged and aged rats. We present evidence which indicates that the effect of eicosapentaenoic acid may be linked with its ability to stimulate activation of peroxisome proliferator‐activated receptor gamma.
Society already achieves economic benefits from generic substitution but fails to do the same for therapeutic substitution.

AIMS To assess the potential annual savings due to generic and therapeutic substitution of statin therapy for the general Dutch population, taking the patients medical history into account. METHODS We conducted a population-based costing study using the PHARMO Record Linkage System (RLS). PHARMO RLS contains drug dispensing records from a representative sample of pharmacies located in more than 50 regions in the Netherlands. We selected all statin users in the database since 2003. The cost-savings of generic substitution of statin therapy for all simvastatin and pravastatin users, and of therapeutic substitution of statin therapy for other statin users were calculated. Substituting current users and new users of statins were considered separately. Therapeutic substitution was based on the medical history of the individual patient. Patients were only substituted if there was an appropriate substitute available. The appropriateness of substitution was based on drug-drug interactions between statins and possible comedication and the availability of an equipotent alternative. RESULTS Substituting (generic and therapeutic) statin therapy for all current users would lead to potential annual savings of approximately 87 million euros. Substituting (generic and therapeutic) all starters on statin therapy would lead to potential annual savings of around 51 million euros. In the case of generic substitution only, the potential annual savings for all current simvastatin and pravastatin users would be 2.4 million euros and for the new users about 1.8 million euros. CONCLUSIONS From an economic point of view, society could gain a lot from substituting statin therapy, especially from therapeutic substitution.
Ameliorating health informatics based on postulates proclaimed by efficacious users in online forums

Extraction of knowledge from online communities through user forums and discussion portals hold primary significance in health informatics. The posts which includes reviews, suggestions, feedbacks etc. in online forums is voluminous Big Data from which the information regarding a particular health issue is mined for the betterment of patient, pharmaceutical industry and medical society. These information should be trustworthy i.e. posted by trusted user. There is need to ascertain the user's credibility who posts the information. In the existing works the user participation with respect to number of posts and their membership tenure is used as metrics for measuring their trust. However these metrics are not sufficient to determine the efficacious user which does not completely yield trustworthy result. Thus we propose a strengthened methodology to classify the efficacious users thereby increasing the probability of trustworthy posts. In addition to the existing metrics, the efficacious users are chosen based on a selective set of criteria: User intents, Credibility and their expertise. These findings can open new avenues of research into rapid data collection and provides up-to-date information for the pharmaceutical industry, hospitals and medical staffs on the effectiveness of future treatments.
Robust vehicles extraction in a video-based intelligent transportation systems

With the increase of vehicle possession, video-based intelligent transportation systems have been of major importance for enforcing traffic management policies. We propose a real-time and robust method for detecting vehicles from a sequence of traffic images taken by a single roadside mounted camera. The proposed algorithm includes three stages: first, extract moving object region from the current input image by the background subtraction method, second, eliminate moving cast shadow which is caused by moving vehicle, and finally, detect the vehicle so that there can be a unique object associated with each vehicle. The proposed method has been tested on a number of monocular traffic-image sequences and the experimental results on the real-world videos show that the algorithm is effective and real-time. The correct rate of vehicle detection is higher than 93 percent, independent of environmental conditions.
An outbreak of Pseudomonas mastitis.

Abstract Extract Pseudomonas aeruginosa infection has been reported in association with an outbreak of mastitis following intramam-mary infusion of cows with dry cow therapy (1) . The mastitis in that case was clinically severe and the reported mortality rate was 17%. The contaminated material was infused at drying off and the cows became affected soon after calving (2–3 months later). We report a similar outbreak of mastitis in a Thames Valley dairy herd.
Direct buck-type AC/AC converter based on switched-capacitor

Switched-capacitor (SC) converters - mainly non-isolated DC-DC converters - have been a very important research topic for many years. Recently, switched capactitors have also been applied in direct AC-AC conversion, and studies have presented two different bidirectional SC ac-ac converters, which intended to replace the conventional auto-transformer in commercial and residential applications. The analysis of one of the presented converters shows that, by sacrificing the bidirectionality, the circuit can be shortened, resulting in a reduction of its overall cost and size. The proposed change modifies the behavior of the converter in each operational stage, thus a new analysis is needed. Therefore, this paper studies, describes, analyzes, designs and tests the proposed new topology. The paper also compares the new converter with the previous topology and presents its advantages, disadvantages and applications. In order to demonstrate the performance of that converter, the design example and experimental results of a prototype of 1 kW, 220/110 V input/output voltages, and switching frequency of 100 kHz, are reported herein. The maximum and nominal efficiencies shown by the prototype were 97.6% and 96.1%, respectively.
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma.

PURPOSE Renal cell carcinoma (RCC) is characterized by loss of von Hippel Lindau tumor suppressor gene activity, resulting in high expression of pro-angiogenic growth factors: vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF). SU11248 (sunitinib malate), a small molecule inhibitor with high binding affinity for VEGF and PDGF receptors, was tested for clinical activity in patients with metastatic RCC. PATIENTS AND METHODS Patients with metastatic RCC and progression on first-line cytokine therapy were enrolled onto a multicenter phase II trial. SU11248 monotherapy was administered in repeated 6-week cycles of daily oral therapy for 4 weeks, followed by 2 weeks off. Overall response rate was the primary end point, and time to progression and safety were secondary end points. Results Twenty-five (40%) of 63 patients treated with SU11248 achieved partial responses; 17 additional patients (27%) demonstrated stable disease lasting > or = 3 months. Median time to progression in the 63 patients was 8.7 months. Dosing was generally tolerated with manageable toxicities. CONCLUSION SU11248, a multitargeted receptor tyrosine kinase inhibitor of VEGF and PDGF receptors, demonstrates antitumor activity in metastatic RCC as second-line therapy, a setting where no effective systemic therapy is presently recognized. The genetics of RCC and these promising clinical results support the hypothesis that VEGF and PDGF receptor-mediated signaling is an effective therapeutic target in RCC.
TANGENTS TO SUBSOLUTIONS EXISTENCE AND UNIQUENESS

There is an interesting potential theory associated to each degenerate elliptic, fully nonlinear equation f(Du) = 0. These include all the potential theories attached to calibrated geometries. This paper begins the study of tangents to the subsolutions in these theories, a topic inspired by the results of Kiselman in the classical plurisubharmonic case. Fundamental to this study is a new invariant of the equation, called the Riesz characteristic, which governs asymptotic structures. The existence of tangents to subsolutions is established in general, as is the existence of an upper semi-continuous density function. Two theorems establishing the strong uniqueness of tangents (which means every tangent is a Riesz kernel) are proved. They cover all O(n)-invariant convex cone equations and their complex and quaternionic analogues, with the exception of the homogeneous Monge-Ampère equations, where uniqueness fails. They also cover a large class of geometrically defined subequations which includes those coming from calibrations. A discreteness result for the sets where the density is≥ c > 0 is also established in any case where strong uniqueness holds. A further result (which is sharp) asserts the Hölder continuity of subsolutions when the Riesz characteristic p satisfies 1 ≤ p < 2. Many explicit examples are examined. The second part of this paper is devoted to the “geometric cases”. A Homogeneity Theorem and a Second Strong Uniqueness Theorem are proved, and the tangents in the Monge-Ampère cases are completely classified. ∗Partially supported by the N.S. F.
Attribute reduction in fuzzy decision formal contexts

The classical concept lattices express the precise relation between object sets and attribute sets, but fuzzy concept lattices express the uncertain relation between object sets and attribute sets. Therefore, it is important to study hierarchy fuzzy knowledge from a fuzzy formal context. In this paper, a kind of fuzzy decision formal context is proposed and (α, β) reduct based on this fuzzy decision formal context is defined. Furthermore, we propose a method to judge attribute consistent sets and reducts in fuzzy decision formal contexts. Finally, a Boolean method is also formulated to attribute reduction in fuzzy decision formal context from the view of the discernibility matrix.
LIVING IN THE ONGOING ERA OF HIV / AIDS

This study analyzed empowerment profiles of a diverse online convenience sample of young adults for engaging in HIV risk reduction behaviors. The Condom Use and Sexual Behavioral Empowerment Scale (CUSBES-4, Cronbach’s Alpha .847) proved reliable in capturing empowerment profiles. The CUSBES-4 is grounded in four theories (self-efficacy, stages of change, social support, role models) and assesses four HIV risk reduction behaviors. The research diffused the innovation of an online survey associated with a website providing e-health, including an invitation to co-create website content with the researcher.The study sample (N=201) of heterosexually active young adults (18-25 years) were mostly students (63.2%), white (40.8%), Asian (20.9%), Latino (18.4%), and Black (10.4%)—while using the Internet to access health information (53.2%). Most had steady sexual partners (71.6%), yet reported main partner sexual concurrency (30.3%); other partner sexual concurrency (28.4%); and personal sexual concurrency (24.4%). Backward stepwise regression analysis found not having a main sex partner (B = -.504, SE = .162, p <.01), having more access to devices for the Internet (B = .150, SE = .162, p < .05), a higher score for Empowerment Self-Efficacy (B = .425, SE = .071, p < .001), a higher score for Empowerment Social Support (B = .360, SE = .130, p < .01), and a higher score for Empowerment Role Models (B = .221, SE = .084, p < .01) predicted being in a higher stage of change for engaging in the four HIV risk reduction behaviors; this model accounted for 32.6% of the dependent variable’s variance. Qualitative data highlighted the selection of steady partners and condom use as ways of coping in the era of HIV, as noteworthy emergent themes. Further, findings demonstrated that the ways of coping in the era of HIV and sexual behavior of diverse young adults are influenced by various contextual factors that merit consideration when developing HIV sexual risk reduction e-health interventions.
Serratus plane block: do we need to learn another technique for thoracic wall blockade?

Britain and Ireland. Checking Anaesthetic Equipment 2012. Anaesthesia 2012; 67: 660–8. 31. Mellin-Olsen J, Staender S, Whitaker DK, Smith AF. The Helsinki declaration for patient safety in anaesthesiology. European Journal of Anaesthesiology 2010; 27: 592–7. 32. Wilson IH, Walker IA. Theatre checklists and patient safety. Anaesthesia 2008; 63: 921–3. 33. De Hert S, Imberger G, Carlisle J, et al. Preoperative evaluation of the adult patient undergoing non-cardiac surgery: guidelines from the European Society of Anaesthesiology. European Journal of Anaesthesiology 2011; 28: 684–722.
Data Processing Spheres of Control

There has long been a need for better definition of the audit and control aspects of data processing applications. This paper attempts to satisbt hat need and thereby provide a framework for improving communication between systems analysts and computer scientists. It introduces the concept of spheres of control, which are logical boundaries that exist in all data processing systems, whether manual or automated. The paper describes their essential properties and portrays them as they relate to each other in the batch, on-line, and in-line processing environments. Included are spheres of control that define process bounding for such purposes as recovery, auditing, process commitment, and algorithm (procedure) replacement.
The Relationship Between Public Causal Beliefs and Social Distance Toward Mentally Ill People

Objective: The aim of this study is to investigate the nature of the relationship between public causal beliefs and social distance toward people with mental disorders, particularly schizophrenia and depression. Method: In total, three representative surveys were carried out in Germany, Russia and Mongolia using personal, fully structured interviews. Results: Despite the subjects' different cultural backgrounds, their responses show similar trends with regard to attributing depression and schizophrenia to psychosocial causes: ‘acute stress’ (life event) was most frequently endorsed as the cause for these two disorders. The biological causes (‘brain disease’ and ‘heredity’) were less frequently selected for depression than for schizophrenia. Irrespective of place and type of mental disorder, endorsing biological factors as the cause of schizophrenia was associated with a greater desire for social distance, the same relationship applies to depression in half the instances. Conclusions: It would be premature to draw conclusions with regard to interventions aimed at reducing discrimination based on stigma. However, our study provides stimulus for re-considering the assumptions underlying antistigma interventions: that promulgating biological concepts among the public might not contribute to a desired reduction in social distance toward people with mental disorders.
QoS Aware Scheduling with Optimization of Base Station Power Allocation in Downlink Cooperative OFDMA Systems

Quality-of-Service (QoS) aware scheduling in cooperative orthogonal frequency division multiple access (OFDMA) systems has long been a critical yet challenging research topic for achieving full system utilization. The optimal performance of such systems can only be achieved by joint optimization of various resources (power, bandwidth and etc). In this paper, we investigate the optimization of base station power allocation with QoS requirements in cooperative OFDMA systems. We formulate the QoS aware resource allocation problem and exploit its structure to derive an efficient solution. By employing Lagrangian relaxation, the problem decouples on each subcarrier into a hierarchy of subproblems. Combined with an iterative procedure, some separable and parallel structures could be exploited to obtain an efficient solution. Simulation results demonstrate that our proposed method outperforms previous works in terms of spectrum efficiency and QoS satisfaction.
Complement‐induced activation of MAPKs and Akt during sepsis: role in cardiac dysfunction

Polymicrobial sepsis in mice causes myocardial dysfunction after generation of the complement anaphylatoxin, complement component 5a (C5a). C5a interacts with its receptors on cardiomyocytes (CMs), resulting in redox imbalance and cardiac dysfunction that can be functionally measured and quantitated using Doppler echocardiography. In this report we have evaluated activation of MAPKs and Akt in CMs exposed to C5a in vitro and after cecal ligation and puncture (CLP) in vivo. In both cases, C5a in vitro caused activation (phosphorylation) of MAPKs and Akt in CMs, which required availability of both C5a receptors. Using immunofluorescence technology, activation of MAPKs and Akt occurred in left ventricular (LV) CMs, requiring both C5a receptors, C5aR1 and ‐2. Use of a water‐soluble p38 inhibitor curtailed activation in vivo of MAPKs and Akt in LV CMs as well as the appearance of cytokines and histones in plasma from CLP mice. When mouse macrophages were exposed in vitro to LPS, activation of MAPKs and Akt also occurred. The copresence of the p38 inhibitor blocked these activation responses. Finally, the presence of the p38 inhibitor in CLP mice reduced the development of cardiac dysfunction. These data suggest that polymicrobial sepsis causes cardiac dysfunction that appears to be linked to activation of MAPKs and Akt in heart. —Fattahi, F. , Kalbitz, M. , Malan, E. A. , Abe, E. , Jajou, L. , Huber‐Lang, M. S. , Bosmann, M. , Russell, M. W. , Zetoune, F. S. , Ward, P. A. Complement‐induced activation of MAPKs and Akt during sepsis: role in cardiac dysfunction. FASEB J. 31, 4129–4139 (2017). www.fasebj. org—Fattahi, Fatemeh, Kalbitz, Miriam, Malan, Elizabeth A. , Abe, Elizabeth, Jajou, Lawrence, Huber‐Lang, Markus S. , Bosmann, Markus, Russell, Mark W. , Zetoune, Firas S. , Ward, Peter A. , Complement‐induced activation of MAPKs and Akt during sepsis: role in cardiac dysfunction. FASEB J. 31, 4129–4139 (2017)
Bir Hastanede Ev İdaresi Hizmetlerinde Çalışan Personelin İş Yaparken Sağlığını Korumaya Yönelik Aldıkları Önlemlerin ve Karşılaştıkları Sağlık Problemlerinin İncelenmesi

Arastirma bir hastanede ev idaresi hizmetlerinde calisan personelin karsilastigi saglik problemlerini belirlemek amaciyla planlanmis ve yurutulmustur. Bu kesitsel ve tanimlayici arastirmaya Ankara Ili Buyuksehir Belediye sinirlari icinde yer alan bir hastanede gunduz vardiyasinda calisan temizlik isini fiilen yuruten ve gorusmeyi kabul eden tum ev idaresi personeli (n=243) alinmistir. Arastirma kapsamina alinan personelin tamaminin sagligini korumaya yonelik hizmet ici egitim aldigi, egitim alinan konular arasinda temizlik maddeleri (%100.0) ve arac-gerec kullanimi (%99.2) konularini belirtenlerin onde geldigi saptanmistir. Personelin tamami saglik problemi karsilasmamak icin onlem aldigini ve onlem olarak da atiklari hijyen kurallarina uygun olarak topladiklarini, temizlik maddelerinin kullaniminda cilde ve vucuda verecegi zararlardan korunduklarini, is elbisesini is bitiminde degistirdiklerini belirtmislerdir. Ancak tum personelin hizmet ici egitim ve sagligini korumaya yonelik onlem almasina ragmen, 19 personelin (7.8) yaptigi ise bagli olarak saglik problemiyle karsilastigi, karsilasilan saglik problemleri arasinda ellerde alerji olmasini (%36.8), bel agrisini (%31.6) ve enfeksiyon gecirmeyi (%15.7) belirtenlerin ilk sirada yer aldigi belirlenmistir. Bu saglik problemlerinin nedeni olarak da en fazla araclarin agir olmasi (%36.9), kullanilan deterjanin zarar vermesi (%26.3), copleri eldivensiz toplama (%26.3) belirtilmistir. Tum personel hizmet ici egitim ve onlem aldigini belirttigi halde, hala bazi saglik problemleri ile karsilasilmasi egitimde surekliligin saglanmasi gerektigini ortaya koymaktadir
3 × ONU No-Guard-Band Coherent OFDMA-PON Uplink Demonstration Using a Real-Time Transmitter With a Free-Running 100-kHz-Linewidth ECL

In this study, we demonstrate coherent OFDMA-PON uplink transmission experimentally using three optical network units including a 3-Gbaud real-time transmitter prototype. Cooperative digital signal processing at the ONUs and an optical line terminal enable no-guard-band subcarrier-based multiple access with free-running up to 100-kHz-linewidth external cavity lasers over a 40-km fiber link. In addition, we demonstrate the OFDMA-PON uplink with multiformatted and unequally-allocated subcarriers over up to 65-km link to verify the bandwidth flexibility of the proposed uplink. We then extend the experimental results to cases with >3 ONUs via numerical simulation.