Miracle-dz/UniFAR-FTUs huggingface dataset:
CD 164 identifies CD 4 + T cells highly expressing genes associated with malignancy in Sézary syndrome : the Sézary signature genes

Sézary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma (CTCL), is associated with a significantly shorter life expectancy compared to skin-restricted mycosis fungoides. Early diagnosis of SS is, therefore, key to achieving enhanced therapeutic responses. However, the lack of a biomarker(s) highly specific for malignant CD4 T cells in SS patients has been a serious obstacle in making an early diagnosis. We recently demonstrated the high expression of CD164 on CD4 T cells from Sézary syndrome patients with a wide range of circulating tumor burdens. To further characterize CD164 as a potential biomarker for malignant CD4 T cells, CD164 and CD164CD4 T cells isolated from patients with high-circulating tumor burden, B2 stage, and medium/ low tumor burden, B1–B0 stage, were assessed for the expression of genes reported to differentiate SS from normal controls, and associated with malignancy and poor prognosis. The expression of Sézary signature genes: T plastin, GATA-3, along with FCRL3, Tox, and miR-214, was significantly higher, whereas STAT-4 was lower, in CD164 compared with CD164CD4 T cells. While Tox was highly expressed in both B2 and B1–B0 patients, the expression of Sézary signature genes, FCRL3, and miR214 was associated predominantly with advanced B2 disease. High expression of CD164 mRNA and protein was also detected in skin from CTCL patients. CD164 was co-expressed with KIR3DL2 on circulating CD4 T cells from high tumor burden SS patients, further providing strong support for CD164 as a disease relevant surface biomarker.
Mechanistic insights derived from re-establishment of desiccation tolerance in germinating xerophytic seeds: Caragana korshinskii as an example

Germplasm conservation strongly depends on the desiccation tolerance (DT) of seeds. Xerophytic seeds have strong desiccation resistance, which makes them excellent models to study DT. Although some experimental strategies have been applied previously, most methods are difficult to apply to xerophytic seeds. In this review, we attempted to synthesize current strategies for the study of seed DT and provide an in-depth look at Caragana korshinskii as an example. First, we analyze congenital advantages of xerophytes in the study of seed DT. Second, we summarize several strategies used to study DT and illustrate a suitable strategy for xerophytic species. Then, based on our previous studies work with C. korshinskii, a feasible technical strategy for DT re-establishment is provided and we provide illustrate some special molecular mechanisms seen in xerophytic seeds. Finally, several steps to unveil the DT mechanism of xerophytic seeds are suggested, and three scientific questions that the field should consider are listed. We hope to optimize and utilize this strategy for more xerophytic species to more systematically decipher the physiological and molecular processes of seed DT and provide more candidate genes for molecular breeding.
IDENTIFICATION AND CHARACTERIZATION OF HEAT SHOCK PROTEINS IN FOUR EGYPTIAN MAIZE INBRED LINES ( Zea mays L . ) [ 90 ]

The heat shock protein (HSP) family is one of the proteins universally accumulated under heat stress condition. Four Egyptian maize inbred lines (Zea mays L.) were studied to identify heat shock proteins under heat stress at 45°C as protein markers for detecting the thermo-tolerance inbreds. The protein fingerprints of four inbred lines were performed by grain total-soluble protein electcophoretic analysis. The protein electrophoretic analysis showed 18 bands in a distinct pattern of K1 and K7 inbred lines, while 17 bands were present in G342 and Rg59 inbred lines as another distinct pattern indicating different genotypes. The high temperature effect on four maize inbred lines exposed to 45°C for 2 and 4 hours at 14-days old seedlings besides control (25°C) was studied. Several protein bands varied between low and intermediate molecular weights were induced after exposing to heat stress at 45°C. Four bands of heat shock proteins with molecular weights of 82, 22, 17 and 10 kDa appeared in the inbred line K1 after exposing to 45°C for 2 and 4 hours which may be indication of thermo-tolerance. Four and seven bands were enhanced after exposing to high temperature for 4 hours at 45°C which appeared more concentrated in the patterns of K7 and G342 inbred lines, respectively.
Neuromuscular responses to hydration and exercise heat stress

Objective: This study examined the neuromuscular responses to 60 min of self-paced high intensity exercise punctuated with 6 x 1 min -all-outsprints at 10 min intervals in moderate (19.8 -± 0.3-° C) and warm (33.2 -± 0.1-°C), humid (~ 64% relative humidity) conditions with either complete hydration (CF) or without hydration (NF). Design: Seven subjects (mean -± SE; age 20.6 -± 1.1 yr, mass 73.8 -± 4.5 kg, peak power 288 -± 11.3 W) performed the time trial on four separate occasions which were differentiated by ambient temperature and fluid ingestion. For each sprint interval, distance, power output and electromyographic (EMG) data from the rectus femoris and vastus lateralis muscles were recorded. Results: The NF trials resulted in a reduction in body mass for the moderate and warm conditions of 1.7% and 2.1%, respectively. Final rectal temperatures were not different among conditions (~ 38.7 -°C). Total body sweating was higher in the warm condition (19.1 -€“ 21.3 mL/kg/h) compared with the moderate condition (16.1 -€“ 16.5 mL/kg/h; P < 0.05). Neither fluid ingestion nor ambient temperature altered total distance cycled for any of the trials (range 30.1 -€“ 32.6 km). The normalised iEMG (as % maximal voluntary contraction) when compared with the first sprint increased from sprint three for the rectus femoris muscle in both NF and CF but decreased for vastus lateralis muscle. However, the mean percentile frequency shift increased for both vastus lateralis and rectus femoris muscles in both NF and CF.Conclusions: These results suggest that the integrity of the neuromuscular system is adjusted according to hydration status and ambient temperatures during intense self-paced cycling. Author Address: fmarino@csu.edu.au jcannon@csu.edu.au dkay01@postoffice.csu.edu.au URL: http://dx.doi. org/10.1136/bjsm.2008. 054973 http://www.ncbi. nlm.nih. gov/pubmed/19329441 http://bjsm.bmj. com/ http://researchoutput.csu.edu.au/R/-? func=dbin-jumpfull&object_id=12263&local_base=GEN01-CSU01 http://unilinc20.unilinc. edu.au:80/F/? func=direct&doc_number=000099809&local_base=L25 XX
WP / 19 / 47 Struggling to Make the Grade : A Review of the Causes and Consequences of the Weak Outcomes of South Africa ’ s Education System

While South Africa has made significant improvements in basic and tertiary education enrollment, the country still suffers from significant challenges in the quality of educational achievement by almost any international metric. The paper finds that money is clearly not the main issue since the South Africa’s education budget is comparable to OECD countries as a percent of GDP and exceeds that of most peer sub-Saharan African countries in per capita terms. The main explanatory factors are complex and multifaceted, and are associated with insufficient subject knowledge of some teachers, history, race, language, geographic location, and socio-economic status. Low educational achievement contributes to low productivity growth, and high levels of poverty, unemployment, and inequality. Drawing on the literature, the paper sketches some policy considerations to guide the debate on what works and what does not. JEL Classification Numbers: I21, I24, I25, I28
Community-Spanning , Network-Spanning , and Scientist Innovativeness

This is an exploratory study on the innovativeness of intra-organizational community-spanning and network-spanning scientists. While a large body of the boundary-spanning literature deals with the role of employees crossing organizational, divisional or team boundaries, little is known regarding the effects of spanning communities and networks revolving around different scientific fields. In this study we focus on the medical devices industry where R&D is located at the intersection of medical and technical knowledge. We posit that scientists involved in both communities come across more recombinant opportunities, which increases their innovativeness. This effect will be stronger if they have strong professional connections in both communities, but knowledge diversity makes it questionable if they could successfully take advantage of brokering opportunities. Results from a longitudinal dataset of scientists indicate that community-spanning and network-spanning scientists are indeed more innovative, but that effect reduces with the size of their professional network. The findings of this study contribute to the research on boundary spanners, intra-organizational communities and networks, and recombinant innovation.
1 Under the Influence : using Natural Language in Interactive Storytelling

Interacting in natural language with virtual actors is an important aspect of the development of future Interactive Storytelling systems. We describe a paradigm for speech interfaces in interactive storytelling based on the notion of influence. In this paradigm, the user is mainly a spectator who is however able to interfere with the course of action by issuing advice to the characters. This is achieved by recognising corresponding speech acts and mapping them to the plans which implement characters’ behaviours in the story. We discuss some examples based on a preliminary, yet fully implemented, prototype.
CORRELATION BETWEEN CENTRAL OBESITY AND ADIPONECTIN IN GERIATRIC CORONARY HEART DISEASE PATIENTS

CORRELATION BETWEEN CENTRAL OBESITY AND ADIPONECTIN IN GERIATRIC CORONARY HEART DISEASE PATIENTS Obesity is rapidly becoming a global problem not only in developed countries but also in developing countries such as Indonesia. Visceral obesity (central obesity) is an importance risk for cardiovascular disease and recognition that adipose tissue can be regarded as a large endocrine organ that secreted inflammatory and anti inflammatory molecules (adiponectin). This study aims to know the correlation between central obesity and adiponectin in geriatric coronary heart disease (CHD) patients. This study was cross sectional analytic study of geriatric CHD at out and in patients in Sanglah hospital. Data are presented as group mean ± SD and analyzed by t-test, chi-square, and Pearson correlation with SPSS 12 software. Forty five patients (35 males and 10 females), 23 patient unstable angina pectoris, 14 patient acute myocardial infarction, and 8 patient stable angina pectoris were recruited and examined. There was high prevalence of central obesity 51.1% (23 patients). Mean of log adiponectin were significantly difference between central obese and non central obese (1.80 ± 0.61 vs 1.09 ± 0.41 with p). Central obesity increased risk of hypoadiponectinemia 5 times than non central obesity (p=0.011, CI 95% 1.4-17.8). Waist circumference has negative correlation with log plasma adiponectin (R=-0.663, p<0.001). There was high prevalence of central obesity in geriatric coronary heart disease patients. Central obesity increased risk of hypoadiponectinemia 5 times than non central obesity. Waist circumference has negative correlation with plasma adiponectin. Increased of waist circumference will decrease of adiponectin (cardioprotective protein) and will increase risk of acute coronary syndrome in geriatric patients.
Understanding the requirements for a blindspot monitoring system on tractors from the operator ’ s perspective

Unintentional run-overs occur because the operator of a tractor is unable to physically see all around the machine. Therefore, there is a need to devise an effective blind-spot monitoring system for tractors to prevent unintentional run-overs. The purpose of the study was to identify the locations of blind spots around two types of tractors (i.e., with and without a front-end loader), with the ultimate goal of conceptualizing a blind-spot monitoring system capable of eliminating all existing blind spots. Grids were constructed around all four sides of the tractors to determine the presence of blind spots for drivers of varying sitting height (i.e., 5th, 50th and 95th percentile male for erect and slumped postures) at four horizontal planes representing people of varying stature who might be in the vicinity of the tractor (i.e., standing male, standing female, standing child, kneeling adult). Generally, the proportion of markers not visible decreased as the sitting height increased. Differences between erect and slumped sitting postures were not statistically different suggesting this variable could be ignored in the assessment of blind spots around tractors. The proportion of the markers not visible to the operator varied from 0 to 34%, with higher values observed for the tractor with the frontend loader installed. Values were as high as 42% of the markers not visible for the condition where a passenger was present in the passenger/trainer seat. Use of the existing rear-view mirrors eliminated only a small fraction of the blind spot area around the tractors. Through trial and error, it was determined that five and eight cameras would be required to fully detect the entire blind spot area around the two tractors selected for this study. A blindspot monitoring system composed of five or eight cameras would create substantial additional monitoring burden for the tractor operator and, therefore, is not a feasible solution. A hybrid blindspot monitoring system consisting of cameras and proximity sensors warrants further investigation. CITATION Chen, X. , and D.D. Mann. 2018. Understanding the requirements for a blind-spot monitoring system on tractors from the operator’s perspective. Canadian Biosystems Engineering/Le génie des biosystèmes au Canada 60: 2.33-2.42. https://doi.org/10.7451/CBE.2018. 60.2.33
Fruit and Vegetable Intake and Bone Mineral Density in Residents of Villages Surrounding Tehran

Osteoporosis is a major health problem because of the large health care costs associated with its clinical consequences. It is therefore of great importance to identify modifiable risk factors. We investigated association between fruit and vegetables intake and bone mineral density in rural population of Tehran surroundings. Subjects were a subgroup of a large study on prevalence and causes of vitamin D deficiency in rural population surrounding Tehran, capital of Iran. Fruit and vegetable intake of 82 subjects whose bone mineral density (BMD) was measured and had a 24 hour food recall, was assessed. Weight and height were measured by standard methods. BMD was measured by Dual X-Ray (DXL) (Calscan) method at the heels. Osteopenia and osteoporosis rate in women older than 50 years were 55.5% and 33.3% and in men were 69.2% and 7.7%, respectively. Fruit intake was not correlated with BMD. Vegetable intake was positively associated with BMD just in women. According to interquartile range of vegetable intake women were grouped as those consuming less than 1.5 servings of vegetables per day and those consuming more. The women reported consuming more than 1.5 serving of vegetables had significantly higher T-score (-1.1±0.8 compared with -1.9±1.0, P<0.01). Those consumed more vegetables had high intake of some nutrients such as vitamin C, vitamin A, potassium, magnesium, zinc, folate, iron, sodium, calcium and phosphorus but none of them except for vitamin A (r= 0.03, P<0.05) was correlated with BMD. High consumption of vegetables positively affected bone mineral density in rural women and daily intake of at least 1.5 servings of vegetables could positively affect osteoporosis prevention.
Which values motivate consumers to innovate ?

Consumer innovation is valuable not only to the innovator, but to society as a whole, and therefore modern societies generally aim to support and facilitate consumer innovation. For this purpose, it is helpful that research on the extent of consumer innovation is emerging, but there is still a lack of research on what motivates consumer innovators. In this paper, we report the first study of the value basis of consumer innovation based on a survey study with representative samples in ten European countries (N ? 10000). We find that personal value priorities are significantly related to whether consumers innovate or not, providing additional detailed knowledge of what motivates consumers to innovate. First, we find that on average 7% of participants report that are engaged in innovation activities in their leisure time, which is in line with earlier, single country studies. Second, the value priorities of consumer innovators across all ten countries reflect a stronger openness to change than non-innovators. Third, we find that consumer innovators are less motivated by hedonistic goals and more by concern for other people and society (i.e., Universalism values) than non-innovators, which adds an important dimension to existing knowledge about consumer innovators. With our results, we dig deeper into understanding what motivates and drives consumer innovation, finding that consumer innovators are more concerned with the welfare of others (universalism) than with their own pleasure and gratification (hedonism). With this, we add to the conceptualization of consumer innovation, clearly differentiating consumer innovators from early adopters of innovation, with knowledge of the underlying value priorities that motivate consumers to innovate.
Association between a Tetranucleotide Repeat Polymorphism of SPAG 16 Gene and Cataract inMale

1 School of Public Health and Psychiatry Institute, University of Illinois, 1601 West Taylor Street, 306N Chicago, IL 60612, USA 2 Biological Sciences Department, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Jawahar Nagar, Shameerpet Mandal, R. R. District, Hyderabad 500078, India Department of Paediatric Ophthalmology and Strabismus, Dr. Shroff ’s Charity Eye Hospital, 5027 Kedar Nath Road, Daryaganj, New Delhi 110 002, India
Paper : Effect of Gonal-F on the Rate of Endometrial Wall Thickness Changes in Ovary-Removed Rat in Presence and Absence of Human Chorionic Gonadotropin

Introduction: In implantation, endometrial epithelium is affected by the release of steroid hormones secreted from the ovary and allows the blastocyst to bind. This course is called the “implantation window” and occurs about 4-10 days after the onset of progesterone secretion. Therefore, the endometrium undergoes changes in the configuration of microvilli in the apical membrane, as well as the number and depth of different types of connections between the epithelial cells in the lateral membrane. It also changes in the base membrane in the form of an increase in the thickness of the base laminate, and in membrane folding and cellular skeleton. Ultimately, these changes lead to implantation. Embryo implantation involves different receptors and genes at each stage.
University of Groningen Matlab Software for Spatial Panels

Elhorst (2003, 2010a) provides Matlab routines to estimate spatial panel data models at his Web site. This paper extends these routines to include the bias correction procedure proposed by Lee and Yu (2010a) if the spatial panel data model contains spatial and/or time-period fixed effects, the direct and indirect effects estimates of the explanatory variables proposed by LeSage and Pace (2009), and a selection framework to determine which spatial panel data model best describes the data. To demonstrate these routines in an empirical setting, a demand model for cigarettes is estimated based on panel data from 46 U.S. states over the period 1963 to 1992.
ohun , ohùn : an experimental study of / h / in Yoruba

This article reports the results of an experimental study of the realisation of /h/ in Yoruba. The aim was to determine whether the 1974 orthography convention requiring that òun “3rd Sg” be written without “h” while ohun “thing” be written with the letter between the two words had any empirical basis. The results show that “h” is rather more frequently realised in òun than in ohun. It is then argued that òun has a V-CV structure in harmony with other Yoruba pronouns, and that the dichotomy introduced in the 1974 orthography convention both lacks empirical support and breaks the pattern of Yoruba pronouns.
The Valuation of Technology Strategies : Examining the short and long-term financial returns of licensing

This paper empirically evaluates the short-term and long-term implications of inward licensing, patenting activity and a combined strategy on firm performance. The short-term effects relate to abnormal stock market returns and long-term effects relate to continuous changes in market share. Drawing on a dataset of 104 companies that belong to the energy, materials and consumer staples sectors from the Standard & Poors 500 index, we conduct our empirical analysis using an event study and a fixed effects model for the period 2006-2012. Results show that, in the short-term, companies capitalize on both developing and acquiring technologies. However, companies capture higher cumulative abnormal returns when purchasing intellectual property than when developing and protecting technologies per se. The announcement of licensing agreements in the consumer staples and energy sector yields the highest returns, while the impact is not significant in the materials sector. In the long-term, we find that patenting influences negatively the growth of a company? s market share and this effect is stronger when patenting and in-licensing are performed simultaneously.
Educational Leadership at Municipality Level : Defined Roles and Responsibilities in Legislation

The purpose of this study is to explore the roles and responsibilities that national education legislation in Iceland imposes on municipalities in terms of leadership. A qualitative content analysis was applied to explore the relevant national legislation—that is, education acts, regulations, and curriculum guides—and identify themes by looking for specific words that are characteristic in leadership practices. The findings reveal that policy ends concerning educational leadership of municipalities are somewhat tacit in current national legislation. Yet, the roles and responsibilities that the state delegates to municipalities comprise leadership functions that are distributed in nature and, to a large extent, harmonize with desired leadership practices as emphasized in the literature. Legislation emphasizes comprehensive education, but also includes signs of technocratic homogenization. In the discussion of our findings, we argue that the educational system is quite dependent on the political emphasis at each given time, making it difficult for both municipalities and the state to facilitate a cohesive leadership emphasis. We suggest that closer attention to the local level, and a recognition of it as an important unit and agency for educational development, is of significant importance. These observations will be followed by a further investigation into the actual practice of leadership at the local level.