Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluating an Adjunctive Mobile App to Enhance Psychological Flexibility in Acceptance and Commitment Therapy

The primary aims of this study were to evaluate the feasibility and potential efficacy of a novel adjunctive mobile app designed to enhance the acquisition, strengthening, and generalization of acceptance and commitment therapy (ACT) skills being taught in therapy. A sample of 14 depressed/anxious clients receiving ACT used the ACT Daily app for 2 weeks in a pre–post, open trial design. Participants reported a high degree of program satisfaction. Clients significantly improved over the 2-week period on depression and anxiety symptoms as well as a range of psychological inflexibility measures. Analyses of mobile app data indicated effects of ACT Daily skill coaching on in-the-moment measures of inflexibility and symptoms, with unique effects found for acceptance and mindfulness. Adjunctive ACT mobile apps appear promising in enhancing therapy effects on psychological inflexibility and outcomes. A tailored skill coaching approach like ACT Daily based on randomly prompted assessments may be especially promising.
Effect of body position on skin perfusion pressure in patients with severe peripheral arterial disease.

BACKGROUND Skin perfusion pressure (SPP) has been shown to be useful in the assessment of the severity of peripheral arterial disease (PAD), and ulcers can be cured when the SPP is ≥30-40 mmHg. The purpose of this study was to determine the best body position for measuring SPP in patients with severe PAD. METHODS AND RESULTS We studied 24 limbs of 18 patients with PAD whose SPP was ≤40 mmHg. After patients had been resting supine for 10 min (Position I), their SPP was measured at the dorsum of the foot with a laser Doppler probe. Following measurement in the supine position, SPP was measured in the sitting position after the foot had been extended horizontally for 10 min (Position II), and in the sitting position after the foot had been lowered vertically for 10 min (Position III). SPP increased significantly from Position I to Positions II and III (25.3±10.9 mmHg, 40.6±12.7 mmHg, and 73.4±17.7 mmHg, respectively; P<0.0001). In all patients, SPP values exceeding 30 mmHg were obtained in Position III. CONCLUSIONS The best SPP values were obtained in Position III, which is the ideal position for peripheral arterial circulation in patients with severe PAD.
Prescription Pattern of Antidepressants for Children and Adolescents in Korea Based on Nationwide Data

Antidepressant prescription for youths has recently been on the increase. There is a growing concern over the increasing off-label usage of antidepressants. Current data on off-label antidepressant usage vary across countries and healthcare systems. Therefore, we examined the extent and pattern of antidepressant prescription for Korean children and adolescents using population-based data. Our data was retrieved from the Korean National Health Insurance Service National Sample Cohort of the year 2013. Among 0.2 million children and adolescents aged 6–18 years from the cohort, subjects who had received any antidepressant medication in the year 2013 were investigated for the prescribed medication, concomitant psychotropic medication, and the associated diagnosis. A total of 2,190 children and adolescents (boys, 55.4%) received antidepressant medication. The most common diagnosis was depressive disorders (n = 469, 21.4%), followed by attention-deficit/hyperactivity disorder (n = 442, 20.2%). Among the prescriptions (n = 3,370), escitalopram (n = 650, 24.1%) and fluoxetine (n = 553, 20.5%) were the two most frequently prescribed drugs. A majority of prescriptions (n = 2,039, 60.5%) included concomitant psychotropic agents, consisting of antipsychotics (n = 901, 26.7%), sedatives (n = 263, 26.3%), medication for attention-deficit/hyperactivity disorder (n = 822, 24.4%), and some others. Our study shows the prescription pattern of antidepressants for children and adolescents in Korea, of which a large proportion is off-label. The results call for close monitoring by clinicians treating this population.
Edge state in graphene ribbons: Nanometer size effect and edge shape dependence.

Finite graphite systems having a zigzag edge exhibit a special edge state. The corresponding energy bands are almost flat at the Fermi level and thereby give a sharp peak in the density of states. The charge density in the edge state is strongly localized on the zigzag edge sites. No such localized state appears in graphite systems having an armchair edge. By utilizing the graphene ribbon model, we discuss the effect of the system size and edge shape on the special edge state. By varying the width of the graphene ribbons, we find that the nanometer size effect is crucial for determining the relative importance of the edge state. We also have extended the graphene ribbon to have edges of a general shape, which is defined as a mixture of zigzag and armchair sites. Examining the relative importance of the edge state for graphene ribbons with general edges, we find that a non-negligible edge state survives even in graphene ribbons with less developed zigzag edges. We demonstrate that such an edge shape with three or four zigzag sites per sequence is sufficient to show an edge state, when the system size is on a nanometer scale. The special characteristics of the edge state play a large role in determining the density of states near the Fermi level for graphite networks on a nanometer scale.
Genetic immunization against herpes simplex virus. Protection is mediated by CD4+ T lymphocytes.

Plasmid DNA encoding proteins represent a convenient novel approach to vaccination. We have investigated this "genetic immunization" approach as a means to protect against herpes simplex virus (HSV) infection using a mouse zosteriform model that mimics several aspects of reactivated HSV infection of humans. After i.m. immunization with plasmid DNA-encoding glycoprotein B (gB), (pc-gB), 80% of BALB/c mice were completely protected and lesions were delayed in the remaining animals. Upon pc-gB vaccination, the animals developed both gB- and HSV-specific IgG Ab response and the isotype examination revealed a predominance of IgG2a. These mice also have low levels (1/16) of HSV-neutralizing Abs. Immune splenocytes obtained from pc-gB-immunized mice, when restimulated in vitro with HSV resulted in production of type 1 cytokines. Evidence for CD(8+)-mediated cytotoxic T lymphocyte response was equivocal. Protection could be adoptively transferred to nude mice recipients by CD4+ T cells from pc-gB-immunized mice but not by CD8+ T cells. Our results demonstrate that genetic immunization is a potent means of inducing protection against HSV and that the mechanism of immunity responsible for clearing virus from cutaneous sites is principally by CD4+ T cells. It is likely that these cells are Th1 cells because type 1 cytokines were the major cytokines detected upon in vitro Ag stimulation.
Ireland and its Referendums: Why We Have Them, What We Do with Them, How We Conduct Them

The referendum is a phenomenon which is on the rise in modern political life in many countries - evolving “from a highly exotic constitutional option to one that is increasingly normalized within constitutional practice” - even as some controversy persists about the merits of its use. For its opponents, the referendum has always been objectionable as the most majoritarian of policy-making devices, violating the principle that laws ought to be a result of compromises between different groups, and indeed imperilling democracy, “which can only be properly effected through exclusively representative institutions”. Referendums have frequently been considered to be mechanisms of repression: the point has not been lost that they were effectively introduced to modern political life by their use on three occasions by Napoleon Bonaparte and been made considerable use of by various autocrats ever since.
Cat Bond Spreads: A New Model with an Empirical Validation Using Nonparametric Tests

Previous empirical studies on catastrophe (CAT) bond premium calculations rely almost exclusively on actuarial models, and usually compare their accuracy strictly in terms of in-sample t and predictive power. We contribute to this literature by deriving a utility-based specification for pricing CAT bonds under Hyperbolic Absolute Risk Aversion (HARA), and by proposing two specification tests that use nonparametric estimation techniques to test simultaneously for all possible mis-specifications. Various pricing models are then estimated and tested with data from the primary market for CAT bonds. Our results suggest that the utility-based model we propose not only is well-suited for explaining the risk-return relationship observed in the CAT bond market but also delivers the best performance among the tested models. We also provide new empirical evidence that the aggregate utility function of CAT investors exhibits decreasing absolute risk aversion.
Alterations in the 5' untranslated region of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene influence EPSPS overexpression in glyphosate-resistant Eleusine indica.

BACKGROUND The herbicide glyphosate inhibits the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). Overexpression of the EPSPS gene is one of the molecular mechanisms conferring glyphosate resistance in weeds, but the transcriptional regulation of this gene is poorly understood. The EPSPS gene was found to be significantly up-regulated following glyphosate treatment in a glyphosate-resistant Eleusine indica population from southern China. To further investigate the regulation of EPSPS overexpression, the promoter of the EPSPS gene from this E. indica population was cloned and analyzed. RESULTS Two upstream regulatory sequences, Epro-S (862 bp) and Epro-R (877 bp), of EPSPS were obtained from glyphosate-susceptible (S) and -resistant (R) E. indica plants, respectively, by high-efficiency thermal asymmetric interlaced polymerase chain reaction (HiTAIL-PCR). The Epro-S and Epro-R sequences were 99% homologous, except for two insertions (3 and12 bp) in the R sequence. The 12-base insertion in the Epro-R sequence was located in the 5' untranslated region (UTR) pyrimidine nucleotide-rich (Py-rich) stretch element. Promoter activity tests showed that the 12-base insertion resulted in significant enhancement of Epro-R promoter activity, whereas the 3-base insertion had little effect on Epro-R promoter activity. CONCLUSION Alterations in the 5' UTR Py-rich stretch element of EPSPS are responsible for glyphosate-induced EPSPS overexpression. Thus, EPSPS transcriptional regulation confers glyphosate resistance in this E. indica population. © 2018 Society of Chemical Industry.
Image segmentation using joint spatial-intensity-shape features: application to CT lung nodule segmentation

Automatic segmentation of medical images is a challenging problem due to the complexity and variability of human anatomy, poor contrast of the object being segmented, and noise resulting from the image acquisition process. This paper presents a novel feature-guided method for the segmentation of 3D medical lesions. The proposed algorithm combines 1) a volumetric shape feature (shape index) based on high-order partial derivatives; 2) mean shift clustering in a joint spatial-intensity-shape (JSIS) feature space; and 3) a modified expectation-maximization (MEM) algorithm on the mean shift mode map to merge the neighboring regions (modes). In such a scenario, the volumetric shape feature is integrated into the process of the segmentation algorithm. The joint spatial-intensity-shape features provide rich information for the segmentation of the anatomic structures or lesions (tumors). The proposed method has been evaluated on a clinical dataset of thoracic CT scans that contains 68 nodules. A volume overlap ratio between each segmented nodule and the ground truth annotation is calculated. Using the proposed method, the mean overlap ratio over all the nodules is 0.80. On visual inspection and using a quantitative evaluation, the experimental results demonstrate the potential of the proposed method. It can properly segment a variety of nodules including juxta-vascular and juxta-pleural nodules, which are challenging for conventional methods due to the high similarity of intensities between the nodules and their adjacent tissues. This approach could also be applied to lesion segmentation in other anatomies, such as polyps in the colon.
Reducing use of indwelling urinary catheters and associated urinary tract infections.

BACKGROUND Use of indwelling urinary catheters can lead to complications, most commonly catheter-associated urinary tract infections. Duration of catheterization is the major risk factor. These infections can result in sepsis, prolonged hospitalization, additional hospital costs, and mortality. OBJECTIVES To implement and evaluate the efficacy of an intervention to reduce catheter-associated urinary tract infections in a medical intensive care unit by decreasing use of urinary catheters. METHODS Indications for continuing urinary catheterization with indwelling devices were developed by unit clinicians. For a 6-month intervention period, patients in a medical intensive care unit who had indwelling urinary catheters were evaluated daily by using criteria for appropriate catheter continuance. Recommendations were made to discontinue indwelling urinary catheters in patients who did not meet the criteria. Days of use of a urinary catheter and rates of catheter-associated urinary tract infections during the intervention were compared with those of the preceding 11 months. RESULTS During the study period, 337 patients had a total of 1432 days of urinary catheterization. With use of guidelines, duration of use was significantly reduced to a mean of 238.6 d/mo from the previous rate of 311.7 d/mo. The number of catheter-associated urinary tract infections per 1000 days of use was a mean of 4.7/mo before the intervention and zero during the 6-month intervention period. CONCLUSIONS Implementation of an intervention to judge appropriateness of indwelling urinary catheters may result in significant reductions in duration of catheterization and occurrences of catheter-associated urinary tract infections.
A review of recently published qualitative research in general practice. More methodological questions than answers?

OBJECTIVE This study aimed to review published papers which use qualitative interviewing in general practice as their methodology. To look specifically at the detail of how the methodology is presented to the reader, with particular emphasis on the clarity of detail about recruitment, the relationship of the interviewer to the respondents, the setting and how the research was presented to the respondents. METHODS AND RESULTS A systematic search using Medline and hand searching the British Journal of General Practice, Family Practice and Social Science and Medicine identified 29 recent papers using qualitative interviewing techniques in general practice. The papers were analysed for eight methodological criteria by the author. A second analysis, blind to the results of the first analysis was performed by the author 6 weeks later. An independent assessor analysed 12 randomly selected papers. There was 98.3% intra-assessor agreement and 89.6% inter-assessor agreement about whether the eight criteria were met. Overall 140 of a possible 232 criteria were met (60.3%). CONCLUSION Published papers using qualitative interviewing in general practice often lack explicit methodological detail about the relationship between the interviewer and the respondents, the setting, who did the recruiting and how the research was explained to the respondents. This methodological detail is important for the critical appraisal of qualitative research, where the context of the research can influence the data.
Design of circularly polarized loop tag antenna for UHF band RFID application

A novel circularly polarized (CP) loop tag antenna for a UHF band (902-928 MHz) RFID tag is proposed. The structure of the proposed tag antenna is a square loop type loaded with an open gap, two feeding strips, and a matching stub. Besides achieving satisfactory 3-dB axial ratio bandwidth of 5.45% and 10-dB impedance bandwidths of approximately 5.5%, good antenna gain and reading range of more than 2.8 dBic and 16.3 m, respectively, were also demonstrated.
A Phase I study of AMGN‐0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases

Osteoprotegerin (OPG) is a decoy receptor for OPG ligand (OPGL), or receptor activator of NF‐κB ligand (RANKL). RANKL/RANK interaction is important in terminal differentiation and activation of osteoclasts. In binding to RANKL, OPG blocks differentiation and activation of osteoclasts. AMGN‐0007 is a recombinant OPG construct developed as a potential therapeutic agent in the treatment of bone disease.
Adaptive protocol for differentially modulated cooperative communications

In this paper, an adaptive protocol is proposed for differentially encoded cooperative communications achieving full rate with an amplify-and-forward protocol.The proposed protocol achieves the maximum achievable diversity gain available in such system based on minimizing a tight approximate bound on bit error rate (BER), and is able to optimally choose the best cooperation partners under the slowly-varying fading channels. A sub-optimum power allocation for such systems is also studied, based on a guideline of an optimum power allocation for coherent systems. Simulation results show that the proposed adaptive protocol yields a remarkably lower BER in comparison with existing protocols. Furthermore, the proposed adaptive protocol with sub-optimum power allocation yields significant performance improvement in comparison with the equal power allocation scheme.
Toxicity, Binding, and Permeability Analyses of FourBacillus thuringiensis Cry1 δ-Endotoxins Using Brush Border Membrane Vesicles of Spodoptera exigua and Spodoptera frugiperda

ABSTRACT The binding and pore formation properties of four Bacillus thuringiensis Cry1 toxins were analyzed by using brush border membrane vesicles from Spodoptera exigua andSpodoptera frugiperda, and the results were compared to the results of toxicity bioassays. Cry1Fa was highly toxic and Cry1Ac was nontoxic to S. exigua and S. frugiperda larvae, while Cry1Ca was highly toxic to S. exigua and weakly toxic to S. frugiperda. In contrast, Cry1Bb was active against S. frugiperda but only marginally active against S. exigua. Bioassays performed with iodinated Cry1Bb, Cry1Fa, and Cry1Ca showed that the effects of iodination on toxin activity were different. The toxicities of I-labeled Cry1Bb and Cry1Fa against Spodoptera species were significantly less than the toxicities of the unlabeled toxins, while Cry1Ca retained its insecticidal activity when it was labeled with 125I. Binding assays showed that iodination prevented Cry1Fa from binding to Spodoptera brush border membrane vesicles. 125I-labeled Cry1Ac, Cry1Bb, and Cry1Ca bound with high-affinities to brush border membrane vesicles fromS. exigua and S. frugiperda. Competition binding experiments performed with heterologous toxins revealed two major binding sites. Cry1Ac and Cry1Fa have a common binding site, and Cry1Bb, Cry1C, and Cry1Fa have a second common binding site. No obvious relationship between dissociation of bound toxins from brush border membrane vesicles and toxicity was detected. Cry1 toxins were also tested for the ability to alter the permeability of membrane vesicles, as measured by a light scattering assay. Cry1 proteins toxic to Spodoptera larvae permeabilized brush border membrane vesicles, but the extent of permeabilization did not necessarily correlate with in vivo toxicity.
Population structure over a broad spatial scale driven by nonanthropogenic factors in a wide‐ranging migratory mammal, Alaskan caribou

Wide‐ranging mammals face significant conservation threats, and knowledge of the spatial scale of population structure and its drivers is needed to understand processes that maintain diversity in these species. We analysed DNA from 655 Alaskan caribou (Rangifer tarandus granti) from 20 herds that vary in population size, used 19 microsatellite loci to document genetic diversity and differentiation in Alaskan caribou, and examined the extent to which genetic differentiation was associated with hypothesized drivers of population subdivision including landscape features, population size and ecotype. We found that Alaskan caribou are subdivided into two hierarchically structured clusters: one group on the Alaska Peninsula containing discrete herds and one large group on the Mainland lacking differentiation between many herds. Population size, geographic distance, migratory ecotype and the Kvichak River at the nexus of the Alaska Peninsula were associated with genetic differentiation. Contrary to previous hypotheses, small Mainland herds were often differentiated genetically from large interconnected herds nearby, and genetic drift coupled with reduced gene flow may explain this pattern. Our results raise the possibility that behaviour helps to maintain genetic differentiation between some herds of different ecotypes. Alaskan caribou show remarkably high diversity and low differentiation over a broad geographic scale. These results increase information for the conservation of caribou and other migratory mammals threatened by population reductions and landscape barriers and may be broadly applicable to understanding the spatial scale and ecological drivers of population structure in widespread species.
Hybrid Neural-Network / HMM Approach for Out-Of-Vocabulary Words Rejection in Mandarin Place Name Recognition

In this paper we address the problem of rejecting Out-Of-Vocabulary words in speaker-independent Mandarin place name recognition. We integrate neural network and Hidden Markov Models in an attempt to utilize the strength of both. HMM based acoustic models including keyword models, filler models, and an anti-keyword model were trained to meet our needs. Statistical features are fed to a neural network for further verification. Feed-forward backpropagation network, Elman backpropagation network, and trainable cascadeforward backpropagation network were compared. A baseline models based on conventional N-Best normalization methods was built. Experiment results showed that feed-forward backpropagation network achieved the best performance, which reduced average error rate by 54.4%.
Use of Leishmania donovani Field Isolates Expressing the Luciferase Reporter Gene in In Vitro Drug Screening

ABSTRACT Currently available primary screens for the selection of candidate antileishmanial compounds are not ideal. These techniques are time-consuming, laborious, and difficult to scale and require macrophages, which limit their use for high-throughput screening. We have developed Leishmania donovani field isolates that constitutively express the firefly luciferase reporter gene (luc) as a part of an episomal vector. An excellent correlation between parasite number and luciferase activity was observed. luc expression was stable, even in the absence of drug selection, for 4 weeks. The transfectants were infective to macrophages, and intracellular amastigotes exhibited luciferase activity. The suitability of these recombinant field isolates for in vitro screening of antileishmanial drugs was established. The luciferase-expressing sodium stibogluconate-resistant cell lines offer a model for the screening of compounds for resistance. The system is in routine use at the Central Drug Research Institute, Lucknow, India, for high-throughput screening of newly synthesized compounds.