Miracle-dz/UniFAR-FTUs huggingface dataset:
Tea With Milk? A Hierarchical Generative Framework of Sequential Event Comprehension

To make sense of the world around us, we must be able to segment a continual stream of sensory inputs into discrete events. In this review, I propose that in order to comprehend events, we engage hierarchical generative models that "reverse engineer" the intentions of other agents as they produce sequential action in real time. By generating probabilistic predictions for upcoming events, generative models ensure that we are able to keep up with the rapid pace at which perceptual inputs unfold. By tracking our certainty about other agents' goals and the magnitude of prediction errors at multiple temporal scales, generative models enable us to detect event boundaries by inferring when a goal has changed. Moreover, by adapting flexibly to the broader dynamics of the environment and our own comprehension goals, generative models allow us to optimally allocate limited resources. Finally, I argue that we use generative models not only to comprehend events but also to produce events (carry out goal-relevant sequential action) and to continually learn about new events from our surroundings. Taken together, this hierarchical generative framework provides new insights into how the human brain processes events so effortlessly while highlighting the fundamental links between event comprehension, production, and learning.
Seed Preferences and Digestive Efficiency of Cardinals and Song Sparrows

Laboratory experiments on seed preferences of several species of North American finches have indicated that a major determinant of seed preferences is ease of handling, and that the number of calories per seed, and the potential caloric intake per unit time from each seed type, are less important in determining seed preferences (Willson 1971). In the present study, we used seed gathered from wild plants rather than commercial seed. Metabolic tests permitted the estimate of actual rather than potential caloric intake from each seed type.
Neoadjuvant Therapy in High-Risk Prostate Cancer

High-risk prostate cancer (PCa) is associated with higher rates of biochemical recurrence, clinical recurrence, metastasis, and PCa-specific death, compared to low-and intermediate-risk disease. Herein, we review the various definitions of high-risk PCa, describe the rationale for neoadjuvant therapy prior to radical prostatectomy, and summarize the contemporary data on neoadjuvant therapies. Since the 1990s, several randomized trials of neoadjuvant androgen deprivation therapy (ADT) have consistently demonstrated improved pathological parameters, specifically tumor downstaging and reduced extraprostatic extension, seminal vesicle invasion, and positive surgical margins without improvements in cancer-specific or overall survival. These studies, however, were not exclusive to high-risk patients and were limited by suboptimal follow-up periods. Newer studies of neoadjuvant ADT in high-risk PCa show promising pathological and oncological outcomes. Recent level 1 data suggests neoadjuvant chemohormonal therapy (CHT) may improve longer-term survival in high-risk PCa. Immunologic neoadjuvant trials are in their infancy, and further study is required. Neoadjuvant therapies may be promising additions to the multimodal therapeutic landscape of high-risk and locally advanced PCa in the near future.
Nomophobia among medical residents

Objective To assess the prevalence and severity of nomophobia among medical residents in Menoufia University Hospitals and to assess its relation with anxiety, doctor–patient relationship, and residents' specialty/subspecialty. Background Nomophobia is an abbreviation for 'no-mobile-phone phobia,' which describes anxiety experienced by mobile phone users in its absence; it is the fear of becoming technologically incommunicable. This fear is characterized by physical, psychological, and cognitive symptoms in the context of stress or danger. Patients and methods A descriptive cross-sectional study was conducted on 221 medical residents in Menoufia University Hospitals in the frame of 13 months. They were assessed through predesigned questionnaires to determine the prevalence and severity of nomophobia and anxiety. Doctor–patient relationship was observed through Kalamazoo checklist. Results Prevalence of both nomophobia and anxiety was 100% among the studied group. More than half of the participants had moderate nomophobia and ~ 73% of the participants had mild anxiety. There was a positive moderate correlation between anxiety and nomophobia (r = 0.51), as increasing the severity of anxiety was associated with increasing in severity of nomophobia. Relation between nomophobia and anxiety was significant positive regarding doctor–patient relationship (P < 0.001), whereas a strong negative correlation regarding good doctor–patient relationship (r=−0.37) was detected. There was a highly statistically significant relationship between nomophobia severity and the residents' specialty, as 40% severely nomophobic residents were surgeons and 58.3% of them were gynecologists and obstetricians. Conclusion Prevalence of nomophobia was 100% among medical residents in Menoufia University Hospitals. Approximately half of the studied residents who had a poor doctor–patient relationships had severe nomophobia. Specialty of medical residents had effect on nomophobia severity.
Noise during bone drilling – An unaddressed patient concern during awake craniotomy

Awake craniotomy offers the benefit of preserving postoperative neurologic function in lesions of eloquent cortex in patients presenting for neurosurgery. [1] Gliomas (low grade and high grade), arteriovenous malformations, and mapping extratemporal seizure foci close to eloquent areas in epilepsy surgery are the well‐established indications for this procedure. The reported incidence of complications in this procedure is up to 20% with seizures and respiratory distress being the most common ones. [2] Other challenges such as hypertension, somnolence, agitation, shivering, tight brain, oxygen desaturation, and coughing can also be frequently encountered. The contraindications to awake craniotomy include patient refusal, claustrophobia, morbid obesity, obstructive sleep apnea syndrome, long‐term cognitive disorders, and lack of patient co‐operation. Clinical assessment of speech and lateralized motor functions, a standard of practice in awake craniotomy, have been supplemented by intraoperative motor cortex mapping using direct cortical stimulation motor evoked potentials (MEP). [3] Despite a strict inclusion criteria for patient selection to this procedure, there are multiple hurdles involved in the conduct of awake craniotomy. We describe here the successful mitigation of noise perceived by a patient during awake craniotomy and present our technique as a novel method to tide over similar crossroads.
A review of the efficacy of mycotoxin detoxifying agents used in feed in light of changing global environment and legislation

In the recent years, mycotoxins have undoubtedly gained a keen interest of the scientific community studying food safety. The main reason is their profound impact on both human and animal health. International surveys reveal a low percentage of feed samples being contaminated above permitted/guideline levels, developed to protect consumers of animal derived products. However, the deleterious impact of feed co-contaminated at low levels with numerous both known and regulated as well as novel mycotoxins on producing animals has been described. Associated effects on agro-economics world-wide include substantial pecuniary losses which are borne by the society as a whole. Even though good agronomic practice is thought to be the most effective way of preventing animal feed contamination, the EC have recognised the need to introduce an additional means of management of feed already contaminated with low-levels of mycotoxins to alleviate detrimental effects on agricultural production efficiency. This review discu.
Comparative Efficacy and Safety of Clonazepam versus Nortrptilline on Menopausal Symptom among Forty Plus Women: A Prospective, Open-Label Randomized Study

Aims and Objectives: The aim of this study is to compare the effect of clonazepam and nortryptiline on menopausal symptoms in above 40 years women. Materials and Methods: A prospective, randomized, open-label comparative study was conducted in a tertiary care teaching hospital for 1 year. Patients were randomized into two groups. Both the groups had 60 patients, out of which Group A had 39 menopausal patients and Group B had 31 menopausal patients, respectively. Group 1 received tablet clonazepam 0.5 mg bed time orally daily. Group 2 received tablet nortryptiline 25 mg bed time orally daily. The primary efficacy end points were effect on menopausal symptoms evaluated by at 0, 4, and 8 weeks. Results: Mean age since menopause was 45 ± 4.06 years, and the mean number of years since menopause was 9.18 ± 7.59 years clonazepam and nortryptiline recorded statistically comparable effect with numerical superiority of nortryptiline both at 4 and 8 weeks on mean Menopausal Symptom Score, thereby indicating that both the drugs may have directly/indirectly improved the mean menopausal symptoms equally. Improvement in the clonazepam group was numerically and statistically more than nortryptiline group at 4 and 8 weeks on mean Vasomotor Symptom Score withP < 0.01 in clonazepam group andP < 0.05 in nortryptiline group both at 4 and 8 weeks. Both the drugs showed comparable results on psychosocial symptom score both at 4 and 8 weeks with numerical superiority in nortryptiline group. Clonazepam group showed more improvement on mean physical score than nortryptiline group numerically and statistically. Both the drugs showed comparable results on mean sexual symptom score at 4 weeks, but nortryptiline proved to be statistically better at 8 weeksP < 0.01 versusP < 0.05 in clonazepam group. Conclusion: Clonazepam and nortryptiline recorded statistically comparable effect at 4 and 8 weeks on mean menopausal symptom. Both the drugs were equally safe and did not recorded any serious Adverse Drug Reaction (ADRs).
Associations between Plasma Branched Chain Amino Acids and Health Biomarkers in Response to Resistance Exercise Training Across Age

Leucine, isoleucine and valine (i.e., the branched chain amino acids, BCAA) play a key role in the support of tissue protein regulation and can be mobilized as energy substrates during times of starvation. However, positive relationships exist between elevated levels of BCAA and insulin resistance (IR). Thus, we sought to investigate the links between fasting plasma BCAA following a progressive resistance exercise training (RET) programme, an intervention known to improve metabolic health. Fasting plasma BCAA were quantified in adults (young: 18–28 y, n = 8; middle-aged: 45–55 y, n = 9; older: 65–75 y, n = 15; BMI: 23–28 kg/m2, both males and females (~50:50), in a cross-sectional, intervention study. Participants underwent 20-weeks whole-body RET. Measurements of body composition, muscle strength (1-RM) and metabolic health biomarkers (e.g., HOMA-IR) were made at baseline and post-RET. BCAA concentrations were determined by gas-chromatography mass spectrometry (GC-MS). No associations were observed across age with BCAA; however, RET elicited (p < 0.05) increases in plasma BCAA (all age-groups), while HOMA-IR scores reduced (p < 0.05) following RET. After RET, positive correlations in lean body mass (p = 0.007) and strength gains (p = 0.001) with fasting BCAA levels were observed. Elevated BCAA are not a robust marker of ageing nor IR in those with a healthy BMI; rather, despite decreasing IR, RET was associated with increased BCAA.
Selection for ancient periodic motifs that do not impart DNA bending

A ~10–11 bp periodicity in dinucleotides imparting DNA bending, with shorter periods found in organisms with positively-supercoiled DNA and longer periods found in organisms with negatively-supercoiled DNA, was previously suggested to assist in DNA compaction. However, when measured with more robust methods, variation in the observed periods between organisms with different growth temperatures is not consistent with that hypothesis. We demonstrate that dinucleotide periodicity does not arise solely by mutational biases but is under selection. We found variation between genomes in both the period and the suite of dinucleotides that are periodic. Whereas organisms with similar growth temperatures have highly variable periods, differences in periods increase with phylogenetic distance between organisms. In addition, while the suites of dinucleotides under selection for periodicity become more dissimilar among more distantly-related organisms, there is a core set of dinucleotides that are strongly periodic among genomes in all domains of life. Notably, this core set of periodic motifs are not involved in DNA bending. These data indicate that dinucleotide periodicity is an ancient genomic architecture which may play a role in shaping the evolution of genes and genomes.
Impact of Menthol on Growth and Photosynthetic Function of Breviolum Minutum (Dinoflagellata, Dinophyceae, Symbiodiniaceae) and Interactions with its Aiptasia Host

Environmental change, including global warming and chemical pollution, can compromise cnidarian‐(e.g., coral‐) dinoflagellate symbioses and cause coral bleaching. Understanding the mechanisms that regulate these symbioses will inform strategies for sustaining healthy coral–reef communities. A model system for corals is the symbiosis between the sea anemone Exaiptasia pallida (common name Aiptasia) and its dinoflagellate partners (family Symbiodiniaceae). To complement existing studies of the interactions between these organisms, we examined the impact of menthol, a reagent often used to render cnidarians aposymbiotic, on the dinoflagellate Breviolum minutum, both in culture and in hospite. In both environments, the growth and photosynthesis of this alga were compromised at either 100 or 300 µM menthol. We observed reduction in PSII and PSI functions, the abundances of reaction‐center proteins, and, at 300 µM menthol, of total cellular proteins. Interestingly, for free‐living algae exposed to 100 µM menthol, an initial decline in growth, photosynthetic activities, pigmentation, and protein abundances reversed after 5–15 d, eventually approaching control levels. This behavior was observed in cells maintained in continuous light, but not in cells experiencing a light–dark regimen, suggesting that B. minutum can detoxify menthol or acclimate and repair damaged photosynthetic complexes in a light‐ and/or energy‐dependent manner. Extended exposures of cultured algae to 300 µM menthol ultimately resulted in algal death. Most symbiotic anemones were also unable to survive this menthol concentration for 30 d. Additionally, cells impaired for photosynthesis by pre‐treatment with 300 µM menthol exhibited reduced efficiency in re‐populating the anemone host.
Dopamine effects on memory load and distraction during visuospatial working memory in cognitively normal Parkinson’s disease

ABSTRACT Visuospatial working memory (WM) impairments in Parkinson’s disease (PD) are more prominent and evolve earlier than verbal WM deficits, suggesting some differences in underlying pathology. WM is regulated by dopaminergic neurotransmission in the prefrontal cortex, but the effect of dopamine on specific processes supporting visuospatial WM are not well understood. Dopamine therapeutic effects on different WM processes may also differ given the heterogeneity of cognitive changes in PD. The present study examined the effect of dopamine therapy on memory load and distraction during visuospatial WM. Exploratory analyses evaluated whether individual differences in medication effects were associated with a gene, catechol-O-methyltransferase (COMT), which regulates prefrontal cortex dopamine levels. Cognitively normal PD participants (n = 28) and controls (n = 25) performed a visuospatial WM task, which manipulated memory load and the presence/absence of distractors. PD participants performed the task on and off medication. PD COMT groups were comprised of Met homozygote (lower COMT activity) and heterozygote and Val homozygote carriers (higher COMT activity, Het/Val). The results showed that handling higher memory loads and suppressing distraction were impaired in PD off, but not on medication. Medication improved distraction resistance in Met, but not Het/Val group. COMT did not modulate medication effects on memory load. These findings demonstrate that dopaminergic therapy restores visuospatial WM processes in patients without cognitive impairment and suggest that COMT variants may partly explain the mixed effects of medication on specific processes governed by distinct brain systems. Future investigations into gene-modulated effects of medication could lead to individualized strategies for treating cognitive decline.
Moving from trends to benchmarks by using regression tree analysis to find inbreeding thresholds in a critically endangered bird

Understanding how inbreeding affects endangered species in conservation breeding programs is essential for their recovery. The Hawaiian Crow (‘Alalā) (Corvus hawaiiensis) is one of the world's most endangered birds. It went extinct in the wild in 2002, and, until recent release efforts starting in 2016, nearly all of the population remained under human care for conservation breeding. Using pedigree inbreeding coefficients (F), we evaluated the effects of inbreeding on Hawaiian Crow offspring survival and reproductive success. We used regression tree analysis to identify the level of inbreeding (i.e., inbreeding threshold) that explains a substantial decrease in ‘Alalā offspring survival to recruitment. Similar to a previous study of inbreeding in ‘Alalā, we found that inbreeding had a negative impact on offspring survival but that parental (vs. artificial) egg incubation improved offspring survival to recruitment. Furthermore, we found that inbreeding did not substantially affect offspring reproductive success, based on the assumption that offspring that survive to adulthood breed with distantly related mates. Our novel application of regression tree analysis showed that offspring with inbreeding levels exceeding F = 0.098 were 69% less likely to survive to recruitment than more outbred offspring, providing a specific threshold value for ongoing population management. Our results emphasize the importance of assessing inbreeding depression across all life history stages, confirm the importance of prioritizing parental over artificial egg incubation in avian conservation breeding programs, and demonstrate the utility of regression tree analysis as a tool for identifying inbreeding thresholds, if present, in any pedigree‐managed population.
Identification of Hub Genes in Anaplastic Thyroid Carcinoma: Evidence From Bioinformatics Analysis

Anaplastic thyroid carcinoma (ATC) is a rare type of thyroid cancer that results in fatal clinical outcomes; the pathogenesis of this life-threatening disease has yet to be fully elucidated. This study aims to identify the hub genes of ATC that may play key roles in ATC development and could serve as prognostic biomarkers or therapeutic targets. Two microarray datasets (GSE33630 and GSE53072) were obtained from the Gene Expression Omnibus database; these sets included 16 ATC and 49 normal thyroid samples. Differential expression analyses were performed for each dataset, and 420 genes were screened as common differentially expressed genes using the robust rank aggregation method. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential bio-functions of these differentially expressed genes (DEGs). The terms and enriched pathways were primarily associated with cell cycle, cell adhesion, and cancer-related signaling pathways. Furthermore, a protein-protein interaction network of DEG expression products was constructed using Cytoscape. Based on the whole network, we identified 7 hub genes that included CDK1, TOP2A, CDC20, KIF11, CCNA2, NUSAP1, and KIF2C. The expression levels of these hub genes were validated using quantitative polymerase chain reaction analyses of clinical specimens. In conclusion, the present study identified several key genes that are involved in ATC development and provides novel insights into the understanding of the molecular mechanisms of ATC development.
Promising Antibiofilm Agents: Recent Breakthrough against Biofilm Producing Methicillin-Resistant Staphylococcus aureus

Multidrug resistant (MDR) methicillin-resistant Staphylococcus aureus (MRSA) is a superbug pathogen that causes serious diseases. One of the main reasons for the lack of the effectiveness of antibiotic therapy against infections caused by this resistant pathogen is the recalcitrant nature of MRSA biofilms, which results in an increasingly serious situation worldwide. Consequently, the development of innovative biofilm inhibitors is urgently needed to control the biofilm formation by this pathogen. In this work, we thus sought to evaluate the biofilm inhibiting ability of some promising antibiofilm agents such as zinc oxide nanoparticles (Zno NPs), proteinase K, and hamamelitannin (HAM) in managing the MRSA biofilms. Different phenotypic and genotypic methods were used to identify the biofilm producing MDR MRSA isolates and the antibiofilm/antimicrobial activities of the used promising agents. Our study demonstrated strong antibiofilm activities of ZnO NPs, proteinase K, and HAM against MRSA biofilms along with their transcriptional modulation of biofilm (intercellular adhesion A, icaA) and quorum sensing (QS) (agr) genes. Interestingly, only ZnO NPs showed a powerful antimicrobial activity against this pathogen. Collectively, we observed overall positive correlations between the biofilm production and the antimicrobial resistance/agr genotypes II and IV. Meanwhile, there was no significant correlation between the toxin genes and the biofilm production. The ZnO NPs were recommended to be used alone as potent antimicrobial and antibiofilm agents against MDR MRSA and their biofilm-associated diseases. On the other hand, proteinase-K and HAM can be co-administrated with other antimicrobial agents to manage such types of infections.
Rationale Therapieentscheidungen bei Intensivpatienten

Was ist neu? Zeitlich begrenzter Therapieversuch (Time-limited Trial, TLT) Kann die Entscheidung für oder gegen eine Intensivtherapie nicht unmittelbar getroffen werden, ist die zeitlich begrenzte Behandlung auf einer Intensivstation eine gute Strategie, um im Verlauf die erforderlichen prognostischen Informationen für die Entscheidung zu gewinnen. Prognosefaktoren im Rahmen einer Intensivbehandlung Die Kenntnis von Prognosefaktoren ist für ein informiertes Patientengespräch relevant. Während das kurzfristige Überleben maßgeblich vom Schweregrad der akuten Erkrankung bestimmt wird, haben Alter und Komorbiditäten einen großen Einfluss auf das langfristige Überleben. Die aus diesen Faktoren resultierende Gebrechlichkeit (Frailty) beeinflusst ebenfalls wesentlich die langfristige Prognose. Konzept für die Entscheidungshilfe bei knappen Ressourcen Stehen nicht ausreichend Ressourcen zur Versorgung aller Patienten zur Verfügung, muss unter dem ärztlichen Handlungsprinzip der Gerechtigkeit eine Priorisierung der Patienten erfolgen. Die aktuellen Leitlinien schlagen in solchen Situationen (z. B. im Rahmen der COVID-19-Pandemie) vor, sich hierbei primär am Kriterium der klinischen Erfolgsaussicht zu orientieren.