Miracle-dz/UniFAR-FTUs huggingface dataset:
Reduction of RANTES expression in lesional psoriatic skin after narrow band ultraviolet therapy: a possible marker of therapeutic efficacy.

BACKGROUND The regulated upon activation, normal T cell expressed and secreted (RANTES) production in psoriatic lesions may amplify the inflammation in these lesions. Narrow band ultraviolet B (NB-UVB), a therapeutic modality for psoriasis, affects the expression of inflammatory cytokines and chemokines. OBJECTIVE Our aim was to evaluate RANTES mRNA expression in skin lesions of psoriasis before and after NB-UVB phototherapy. METHODS This study included 25 psoriatic patients who received 24 sessions of NB-UVB. Skin biopsies were taken before and after phototherapy for real time PCR evaluation of RANTES mRNA. RESULTS The relative quantitation values (RQ) of RANTES mRNA expression was significantly reduced after treatment. A significant negative correlation was found between pre-treatment RQ RANTES mRNA expression and post-treatment PASI score. We found a significant negative correlation between dRQ RANTES mRNA expression (difference between RQ RANTES mRNA expression before and after phototherapy) and PASI score after phototherapy. We found significant negative correlations between pre-treatment RQ RANTES mRNA expression and both initial response session number and total NB-UVB dose at the end of phototherapy. CONCLUSION NB-UVB reduces RANTES mRNA expression in psoriatic lesions. Pre-treatment RQ RANTES mRNA expression could be considered as a marker for clinical improvement and NB-UVB phototherapy efficacy.
A Pilot Study of Individualized Maximum Repeatable Dose (iMRD), a New Dose Finding System, of Weekly Gemcitabine for Patients With Metastatic Pancreas Cancer

Objectives: We developed and established a new dose-finding system, the individualized maximum repeatable dose (iMRD), suitable to induce prolonged TTP rather than tumor shrinkage. Methods: We applied this system in weekly gemcitabine therapy for 18 metastatic pancreas cancer patients. We determined the iMRD at the 5th week, after weekly dose adjustments. We started at 500 mg/m2 (1/2 maximum tolerated dose) of gemcitabine and repeated the treatment with an increase or a decrease of 100 mg/m2 each week, if toxicity was 0 or more than grade 1, respectively. Results: The iMRD of weekly gemcitabine was 300 mg/m2 in 2 patients, 400 mg/m2 in 3 patients, 500 mg/m2 in 5 patients, 600 mg/m2 in 6 patients, and 700 mg/m2 in 2 patients, demonstrating significant differences among individual patients. Grade 3 marrow depression occurred in only 1 patient (5.6%). Of these 18 patients, 3 (16.7%), 13 (72.2%) and 2 (11.1%) patients showed partial response, stable disease, and progressive disease, respectively. The median of times to progressive disease and survival were 4.5 and 9.5 months, respectively. There were no significant differences in 1-year survival time and more than 50% reduction rate of serum CA19-9, a tumor marker for pancreatic cancer, between patients with lower (500 mg/m2 or less) and higher (600 mg/m2 or more) iMRD. Conclusion: These results suggest that iMRD is a simple method to determine an individual's tailored dose for chemotherapy and could be the optimal dose for patients with noncurable cancers such as metastatic pancreas cancer.
Recurrence of hepatocellular carcinoma after surgery

A total of 386 patients who underwent complete resection of hepatocellular carcinoma over an 8‐year period were assessed retrospectively for tumour recurrence. Some 219 (56.7 per cent) of the patients developed recurrence. Patients with a greater degree of cirrhosis showed a longer interval to recurrence; the median (range) interval until recurrence was 7.9 (1.8–84.2) months in patients with a normal liver, 13.4 (2.0–79.5) months in those with chronic hepatitis and 16.7 (1.5–73.1) months in those with cirrhosis. Intrahepatic recurrence was observed more frequently in either the same (26‐4 per cent) or the adjacent (24.8 per cent) Healey segment than in the lobe contralateral to the primary tumour (17.8 per cent). The presence of portal venous invasion and/or intrahepatic metastasis, underlying liver cirrhosis and perioperative blood transfusion were determined to be independent predictors of recurrence by multivariate analysis. Because intrahepatic spread of hepatocellular carcinoma occurs in a segment‐by‐segment manner, surgeons should use an anatomically wide resection within the hepatic functional reserve.
Standard of Living and Disability in Cambodia

Abstract Little is known about the extra costs faced by households with disabled members in low resource settings and the impact of these costs on living standards. In this paper we estimate the direct cost associated with disability for households in Cambodia. Using the Standard of Living approach, the direct cost associated with having a member with disabilities is estimated to be 19 per cent of monthly household consumption expenditure. Accounting for the direct cost of disability doubles the poverty rate amongst households with disabled members from 18 per cent to 37 per cent, and increases the poverty gap from 3 to 8 per cent. A comparison of the direct cost associated with disability and income support received from government and family sources reveals that only 7 per cent of the costs of disability are met. Our findings suggest that, in the absence of increased coverage of public income support, households with disabled members will continue to experience a lower standard of living compared to households without disability in Cambodia.
Development of dynamic EV load model for power system oscillatory stability studies

The interest on electric vehicles growing as a sustainable alternative to fossil fuel driven vehicles. Even though there are a number of grid impact studies, only a scant attention has been paid to study the impact of EV charging on system stability. Electrification of transportation brings significant load integration to the grid. This could profoundly influence stability of the grid. Hence, it is important to understand the EV charging impact on power system stability. The extant literature is largely based on conventional load characteristics rather than actual EV load behaviour, due to the unavailability of proper load models. Hence, this study develops a dynamic EV load model, considering the dynamics of the EV charger and the battery, as an essential basis for system oscillatory stability studies. Dynamic behavior of a power electronically controlled EV load is described by an eleventh order model. The preliminary results suggest that EV load can cause considerable influence on damping performance of electromechanical modes.
Gefitinib in patients with brain metastases from non-small-cell lung cancer: a prospective trial.

BACKGROUND Brain metastases are a common occurrence in patients with non-small-cell lung cancer (NSCLC). Whole-brain radiotherapy (WBRT) is the standard therapy; more aggressive approaches such as surgery or radiosurgery are indicated in a subset of patients only. The role of systemic treatments remains controversial. Gefitinib is an oral, highly tolerable, specific inhibitor of epidermal growth factor receptor-associated tyrosine kinase, which has shown activity in chemotherapy pre-treated NSCLC. The aim of this study was to evaluate the activity and safety of gefitinib in NSCLC patients with brain metastases. PATIENTS AND METHODS From January 2001 to May 2003, 41 consecutive NSCLC patients with measurable brain metastases were treated with gefitinib, given orally at daily dose of 250 mg. Thirty-seven patients had received previous chemotherapy and 18 patients had been treated previously with WBRT, completed at least 3 months before entering the trial. RESULTS A partial response (PR) was observed in four patients (10%), with stable disease (SD) in seven cases, for an overall disease control (DC) rate (DC=PR+SD) of 27% (95% confidence interval 13% to 40%). Median duration of PR was 13.5 months. Median progression-free survival (PFS) of the whole population was 3 months. DC rate was higher in patients pre-treated with WBRT (P=0.05) and with adenocarcinoma histological type (P=0.08); adenocarcinoma patients had also a longer PFS (P=0.04). Toxicity was mild and consisted of grade 1/2 skin toxicity and diarrhoea, occurring in 24% and 10% of patients, respectively. CONCLUSIONS Gefitinib can be active on brain disease in NSCLC patients. Since the results of standard therapy for brain metastases in this clinical setting are particularly disappointing, gefitinib appears to be a possible new treatment option.
Une approche éducative novatrice pour outiller les enfants souffrant d’embonpoint ou d’obésité

L’obésité infantile est d’actualité et très préoccupante à l’échelle planétaire. En 2013, un enfant québécois sur quatre présentait un surplus de poids. Jusqu’à maintenant, la grande majorité des interventions luttant contre cette épidémie demeure centrée sur la nutrition et l’activité physique. Peu d’interventions éducatives touchent directement les mécanismes psychologiques à l’origine de la suralimentation ou de l’inactivité. Cet article a pour but de présenter l’état de la situation et de proposer une nouvelle approche éducative pour intervenir auprès des enfants souffrant d’embonpoint ou d’obésité.
Multiple banking relationships and exposure at default: Evidence from the Italian market

Purpose This paper aims to analyse the exposure at default (EAD) in the event of multiple banking relationships to understand the differences with respect to solo banking relationships and forecast the banks risk exposure. Design/methodology/approach The paper uses a unique database provided by the Italian public credit register representative of the full Italian market before the financial crisis. The analysis compares different EAD risk proxies for debtors with unique and multiple banking relationships to underline the main differences among the two groups. Findings Results show that EAD forecast could be improved considering the existence of exposures with other lenders and banks that consider such type of information can reduce the risk of underestimating the risk exposure of a debtor. Originality/value The paper is the first attempt to model the EAD on the basis of the existence of multiple lending exposures. Results demonstrate a different lender’s risk exposure for debtors with multiple credit risk exposure and show the usefulness of the information about the overall system exposure in evaluating the risk exposure related to this type of customers.
Responses of spinothalamic tract cells in the superficial dorsal horn of the primate lumbar spinal cord.

1. The responses of thirty‐five spinothalamic tract (s.t.t.) cells in or near lamina I of the dorsal horn were examined in chloralose‐ and barbiturate‐anaesthetized monkeys (Macaca fascicularis). Many of the cells could be classified on the basis of receptive field properties as either wide dynamic range (w.d.r.) cells or as high‐threshold (h.t.) cells. 2. Thalamic stimulation sites for antidromic activation of the s.t. t. cells were in or around the ventral posterior lateral nucleus. Axons of the s.t. t. cells had a mean conduction velocity of 17 m/s (33 and 14 m/s for w.d.r. and h.t. cells, respectively). Mean minimum afferent conduction velocity averaged 37 m/s (52 and 23 m/s for w.d.r. and h.t. cells, respectively). Background activity was low (mean of 2.3 impulses/s). 3. An alternative classification of the cells was based on a kappa means cluster analysis of the responses to a series of mechanical stimuli. The response profiles for a given cell were normalized, and those of the s.t. t. cells in or near lamina I were analysed along with the responses of a population of s.t. t. cells, largely in laminae IV‐VI, that had been described previously. S.t. t. cells in or near lamina I were distributed amongst three of the four groups of cells determined by the cluster analysis (types 2‐4). 4. Vibratory stimuli excited most of the w.d. r. but none of the h.t. cells tested. Best frequencies were 5‐10 Hz (at 100 and 500 microns indentations). 5. Most w.d. r. but few h.t. cells responded to cutaneous cooling. All of the cells responded to noxious heating, but w.d. r. cells had steeper stimulus‐response curves. 6. After a series of noxious heat stimuli, the thresholds for noxious heat were lowered and responses to lower‐intensity noxious heat stimuli were enhanced (sensitization). However, responses to more intense stimuli were reduced (inactivation). Similar changes were seen in the responses to graded mechanical stimuli. 7. It is concluded that s.t. t. cells in or near lamina I can signal noxious cutaneous stimuli but have poor coding abilities for innocuous mechanical stimuli. Some of these cells respond to innocuous thermal stimuli, but their role in thermoreception is unclear. The small receptive fields suggest that these cells could contribute to stimulus localization.
Sudden Sensorineural Hearing Loss

Sudden sensorineural hearing loss (SSNHL) is commonly encountered in audiologic and otolaryngologic practice. SSNHL is most commonly defined as sensorineural hearing loss of 30dB or greater over at least three contiguous audiometric frequencies occurring within a 72-hr period. Although the differential for SSNHL is vast, for the majority of patients an etiologic factor is not identified. Treatment for SSNHL of known etiology is directed toward that agent, with poor hearing outcomes characteristic for discoverable etiologies that cause inner ear hair cell loss. Steroid therapy is the current mainstay of treatment of idiopathic SSNHL in the United States. The prognosis for hearing recovery for idiopathic SSNHL is dependent on a number of factors including the severity of hearing loss, age, presence of vertigo, and shape of the audiogram.
ADVANCED NURSING PRACTICE: ON THE FRONT LINES Formerly Incarcerated Women Create Healthy Lives through Participatory Action Research

The specific purpose of the participatory action research study was to facilitate formerly incarcerated women who participate in Welcome Home Ministries (WHM) to develop their own plans and specific strategies, and to take action to build their own healthy futures. The research had a duel purpose of joint generation of knowledge and intervention relative to women’s capacity building. The research intervention was the creation, implementation, and follow-up of a future search conference. The outcomes, conclusions, and implications for practice are discussed.
Harmonic phase angle as a concentration-independent measure of nanoparticle dynamics.

PURPOSE The harmonic spectrum of magnetic nanoparticles contains valuable information about the quantity and environment of the particles. Harmonic amplitudes have been used to produce quantitative images and ratios of these amplitudes have been used to monitor changes in the particle environment. Harmonic phase angles have not yet been utilized in these pursuits. The authors explore harmonic phase angle as a concentration-independent means of remotely monitoring the dynamic magnetization of nanoparticles. METHODS A magnetic nanoparticle spectrometer was used to explore the impacts of viscosity and excitation frequency and amplitude on the phase angle of magnetization harmonics. A dynamic model, which accounts for particle relaxation times, was used to model some results. RESULTS Harmonic phase angle can undergo large changes when a nanoparticle's Brownian motion is altered. Excitation parameters and particle characteristics have a profound effect on the extent of these changes. CONCLUSIONS Phase angle can allow for monitoring of various impacts on a nanoparticle's Brownian motion. When combined with other concentration-independent metrics, such as ratios of harmonic amplitudes, valuable information about the particle's environment can be gathered.
Materials, Devices, and Circuits of Transparent Amorphous-Oxide Semiconductor

This paper presents the following recent investigations of transparent amorphous-oxide semiconductors (TAOS) from materials to devices and circuits. 1) Composition of metals in TAOS are widely explored with the aim of seeking semiconductors suitable for the channel layers of thin-film transistors (TFTs) composing backplanes for flat-panel displays. It is found in combinatorial approaches to the materials exploration that indium-based ternary TAOS (In-X-O) and their TFTs show the properties and the performance as good as those of the most popular material of amorphous In-Ga-Zn-O (alpha-IGZO) when X = Zn or Ge. 2) Defects and impurities in TAOS are investigated by theoretical approaches. The first-principle calculation of the electron states reveals that charge-neutral oxygen vacancy or interstitial forms the density of states around mid-gap level and does not generate carriers directly, while hydrogen impurity raises the Fermi level beyond the conduction-band minimum and acts as a donor in TAOS. 3) Device structures of TAOS-TFTs are also investigated extensively for better performance and stability. It is found in channel-etch type TFTs with bottom-gate inverse-stagger structures that the TFT characteristics and stability are significantly improved by chemically removing the back-channel layer in a wet-etching process. Coplanar homojunction (CH) structure is proposed as a novel device structure where conductive alpha-IGZO regions work as the source and drain electrodes to the channel region of semiconductor alpha-IGZO. The CH TFTs show excellent characteristics and stability, with low series resistance without any difficulty in making good electrical contact between metals and TAOS. 4) Circuits using TAOS-TFTs are demonstrated. A ring oscillator composed of fifteen-stage inverters with a buffer circuit operates as designed by circuit simulation with a TFT model for hydrogenated amorphous Si TFTs. Pixel circuits composed of three TFTs and one transparent capacitor successfully drive organic light-emission diode cells without a planarization layer on a 2-in diagonal panel having 176 times144 times 3 pixels.
Neurotoxicity of Glucocorticoids in the Primate Brain

Severe and prolonged physical and psychological stress is known to cause brain damage; long-term torture victims in prison have later developed psychiatric disorders and cerebral cortical atrophy observed in CT scans (Jensen, Genefke, Hyldebrandt, Pedersen, Petersen, and Weile, 1982). In nonhuman primates, we observed degeneration and depletion of the hippocampal neurons in African green monkeys that had been severely abused by cagemates and died with complications of multiple gastric ulcers and adrenal cortical hyperplasia (Uno, Tarara, Else, Suleman and Sapolsky, 1989). In our previous studies the administration of dexamethasone (DEX) (5 mg/kg) to pregnant rhesus monkeys at 132 to 133 days of gestation induced degeneration and depletion of the hippocampal pyramidal and dentate granular neurons in the brains of 135-gestation-day fetuses, and these changes were retained in the brains of fetuses at near term, 165 days of gestation (Uno, Lohmiller, Thieme, Kemnitz, Engle, Roecker, and Farrell, 1990). We also found that implantation of a cortisol pellet in the vicinity of the hippocampus in adult vervet monkeys induced degeneration of the CA3 pyramidal neurons and their dendritic branches (Sapolsky, Uno, Rebert, and Finch, 1990). Thus, hippocampal pyramidal neurons containing a high concentration of glucocorticoid receptors appear to be highly vulnerable to either hypercortisolemia caused by severe stress or to exposure to exogenous glucocorticoids. To study the long-term postnatal sequelae of prenatal brain damage, eight rhesus monkeys were treated with either DEX (5 mg/kg), 5 animals, or vehicle, 3 animals, at 132 to 133 days of gestation. After natural birth, all animals lived with their mothers for 1 year. At 9 months of age, we found that DEX-treated animals had significantly high plasma cortisol at both base and post-stress (isolation) levels compared to age-matched vehicle-treated animals. Magnetic resonance images (MRI) of the brain at 20 months of age showed an approximately 30% reduction in size and segmental volumes of the hippocampus in DEX-treated compared to vehicle-treated animals. Measurements of whole brain volume by MRI showed no significant differences between DEX and vehicle groups. Prenatal administration of a potent glucocorticoid (DEX) induced an irreversible deficiency of the hippocampal neurons and high plasma cortisol at the circadian baseline and post-stress levels in juvenile rhesus monkeys. These results suggest that the hippocampus mediates negative feedback of cortisol release; a lack or deficiency of the hippocampal neurons attenuates this feedback resulting in hypercortisolemia. (ABSTRACT TRUNCATED AT 400 WORDS)
Does social capital help communities to cope with long-distance commuting?

ABSTRACT Long-distance commuting (LDC) is a common occurrence in rural/remote regions. The literature shows that the impacts of LDC on residents in host regions can be diverse. To understand this diversity, this paper explores the potential mediating role of social capital between LDC impacts in a host region and the well-being of its residents. Using detailed information on residents’ social capital in a remote region, this paper confirms the negative relationship between LDC impacts and resident well-being, but it finds no evidence of social capital’s mediating role. It is hypothesized that lack of access to appropriate linking social capital may explain the findings.
Pulmonary artery smooth muscle cells from chronically hypoxic neonatal calves retain fetal-like and acquire new growth properties.

Growth properties retained and acquired by immature pulmonary artery (PA) smooth muscle cells (SMC) in vivo after chronic exposure to hypoxia and the mechanisms that regulate hypoxia-induced change in proliferative phenotype are not known. We tested the hypothesis that PA SMC from neonatal calves exposed to hypoxia after birth would both retain fetal-like and acquire new growth characteristics and that these changes would be at least partially dependent on protein kinase C (PKC), a key proproliferative signal transduction pathway. Like fetal cells, PA SMC from hypoxic calves grew faster in the presence and absence of serum and were more responsive to insulin-like growth factor I and platelet-derived growth factor-BB than control neonatal and adult cells. PA SMC from hypoxic calves also acquired other growth properties (i.e., including increased hypoxic growth after PKC activation) that were new compared with those observed for fetal cells. The proliferative response to hypoxia was first detectable in the neonatal period and was further increased in cells from hypoxic calves. SMC from fetuses and hypoxic calves were more susceptible to the growth-inhibiting effects of PKC antagonists (dihydrosphingosine and calphostin C) than control neonatal and adult cells. To test if the Ca(2+)-dependent isozymes of PKC were uniquely important in the developmental and acquired growth changes observed, the antagonistic effect of the specific, but isozyme nonselective, PKC inhibitor Ro-81-8220 was then compared with GF-109203X, a structural analog with relative specificity for the Ca(2+)-dependent isozymes of PKC (alpha and beta in PA SMC). The faster growing PA SMC from bovine fetuses and hypoxia-exposed calves again demonstrated greater growth inhibition in response to both inhibitors. GF-109203X was equipotent to Ro-31-8220, and its antiproliferative effects were shown to not be due to an increase in apoptosis. Phorbol ester-induced PKC downregulation, another inhibitor strategy that selectively depletes bovine PA SMC of PKC-alpha, but not -beta, mimicked the antiproliferative effects of GF-109203X. Whole cellular PKC catalytic activity paralleled the pattern of peptide-induced growth and susceptibility to PKC inhibition. These results suggest that PA SMC from hypoxia-exposed neonatal calves retain enhanced fetal-like proliferative capacity and acquire new growth properties that are at least partially dependent on the Ca(2+)-regulated isozymes of PKC and in particular PKC-alpha.