Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of nutrient-sensing taste 1 receptor (T1R) family members in gastrointestinal chemosensing

Luminal nutrient sensing by G-protein-coupled receptors (GPCR) expressed on the apical domain of enteroendocrine cells activates intracellular pathways leading to secretion of gut hormones that control vital physiological processes such as digestion, absorption, food intake and glucose homeostasis. The taste 1 receptor (T1R) family of GPCR consists of three members: T1R1; T1R2; T1R3. Expression of T1R1, T1R2 and T1R3 at mRNA and protein levels has been demonstrated in the intestinal tissue of various species. It has been shown that T1R2–T1R3, in association with G-protein gustducin, is expressed in intestinal K and L endocrine cells, where it acts as the intestinal glucose (sweet) sensor. A number of studies have demonstrated that activation of T1R2–T1R3 by natural sugars and artificial sweeteners leads to secretion of glucagon-like peptides 1&2 (GLP-1 and GLP-2) and glucose dependent insulinotropic peptide (GIP). GLP-1 and GIP enhance insulin secretion; GLP-2 increases intestinal growth and glucose absorption. T1R1–T1R3 combination co-expressed on the apical domain of cholecystokinin (CCK) expressing cells is a luminal sensor for a number of l-amino acids; with amino acid-activation of the receptor eliciting CCK secretion. This article focuses on the role of the gut-expressed T1R1, T1R2 and T1R3 in intestinal sweet and l-amino acid sensing. The impact of exploiting T1R2–T1R3 as a nutritional target for enhancing intestinal glucose absorption and gut structural maturity in young animals is also highlighted.
Risk-Managed 52-Week High Industry Momentum, Momentum Crashes, and Hedging Macroeconomic Risk

This is the first study to investigate the profitability of Barroso and Santa-Clara’s (2015) risk-managing approach for George and Hwang’s (2004) 52-week high momentum strategy in an industrial portfolio setting. The findings indicate that risk-managing adds value as the Sharpe ratio increases, and the downside risk decreases notably. Even after controlling for the spread of the traditional 52-week high industry momentum strategy in association with standard risk factors, the risk-managed version generates economically and statistically significant payoffs. Notably, the risk-managed strategy is partially explained by changes in cross-sectional return dispersion, whereas the traditional strategy does not appear to be exposed to such economic risks.
Application of arduino based platform for wearable health monitoring system

World's ageing population and predominance of obstinate diseases have led to a high demand of ambulatory healthcare system, which can monitor vital-signs. Our aim is to develop a generic clothing technology which successfully integrates biosensors woven into a shirt. We have therefore developed an ambulatory device which enables the measurement of heart rate, electro dermal activity, and skin temperature with non-invasive sensors. Since we are combining parameters such as body temperature and galvanic skin resistance, we get to know about the patient's integral condition. One of the key features of our system is fall detection, which mainly arises from the complication of heart attack during which body's vitals-sign changes and patient tends to collapse. This system gives warning to prevent such complications. Our research is mainly orientated towards two complementary directions: Improving the relevancy of each sensor and increasing the number of sensors for having a more synthetic and robust information.
Literacy and numeracy demands and usage in the workplace

This research focuses on the demand for and use of literacy and numeracy skills in low paid work. The motivation for the research is to examine the assumption, widely espoused by policy makers, that literacy and numeracy skills are vital at all levels of the labour market and that deficiencies in these skills are the source of widespread economic problems. The primary aim of this study is to understand the extent to which employees in low paid occupations use literacy and numeracy skills in their work. Alongside this, the research considers the extent of mismatch between the skills of employees and the demands of their job, the extent of change in the demand for literacy and numeracy skills and the sources of demand for literacy and numeracy skill. Methodologically the research focuses on qualitative case studies of frontline work in two major low paying sectors, retail and residential care. Research took place in three Nursing Homes in England and three retail outlets in South Wales. This qualitative analysis is supplemented by a quantitative analysis of the Skills and Employment Surveys from 1997 to 2012, which provides a broader picture of the extent of and changes in the use of literacy and numeracy skills in low paid work. The research raises doubts about the extent of demand for literacy and numeracy skills in occupations at the lower end of the labour market and the incidence of deficiencies in the skills of employees. This in turn leads to questions about the viability of approaches to literacy and numeracy policy predicated on these assumptions.
Preferences regarding external information sources: a conjoint analysis of visitors to Sardinia, Italy

ABSTRACT Utilizing a conjoint analysis approach, this study aims to examine the relative importance of external information sources for female and male international and domestic travelers utilizing data collected from 719 tourists traveling to Sardinia (Italy). Overall, findings reveal that traditional word-of-mouth (i.e. family and friends), online review sites (e.g. TripAdvisor), and the online search engines are the most important external information sources for both domestic and international travelers. However, differences in importance tourists assign to each external source exist based on type of travel (domestic versus international) and gender (male versus female). For example, while traditional word-of-mouth, online review sites, and search engines are the three most important sources for domestic male travelers, the third most important information source for domestic female travelers is found to be printed tour guides. Contributions to the current body of knowledge and managerial implications are discussed, and suggestions for further research are provided.
Breast Cancer Epidemiology and Risk Factors

Between the years 2010 and 2012, the lifetime probability of developing female breast cancer was 12.3%, or approximately 1 in 8. Worldwide, breast cancer is the most common cancer in women. Survival is increasing. Between 2005 and 2011, the 5-year relative survival was found to be 89%. This is thought to be due to both the increase in utilization of population-wide screening, as well as advances in treatment. Less than 10% of breast cancers can be attributed to an inherited genetic mutation. Breast cancer is more commonly associated with environmental, reproductive, and lifestyle factors, some of which are potentially modifiable.
Internationalization of academic journal in UIN Maulana Malik Ibrahim Malang: Accessability, credibility, prestige

Internationalization can be one of strategic ways to construct a World Class University (WCU) by implementing the global standards in educational boundaries. Although it is controversial, most of universities are in the process on how to accomplish the international recognition, particularly in global dissemination. Responding to that, this research is aimed at investigating the internationalization of academic journals at UIN Maulana Malik Ibrahim Malang dealing with accessibility, credibility and prestige in the process to elevate the quality of academic journals that are published online or printed version. By employing the descriptive qualitative research, focusing on case study, this research collected the data through focused group discussions and spreading a number of questions from google form to gain data about the reasons and the expectations on the enhancement of academic journals. In so doing, this research found several aspects harnessed by the academic journal managers and the academics. The main issues are centered on enlarging the accessibility of journal publication to accentuate the criteria of accessibility and credibility. The last topic concentrates on the intention of the writers to purposively choose journal at UIN Maulana Malik Ibrahim Malang as a media for publication. The findings exemplify that the internationalization in the part of accessibility is done by registering the journals on index machines and using international language to widely attract readers not restricted from Indonesian. Those can influence the number of visitors that can be detected from flag counter application. In addition, the performance of the website that can be analyzed by using the tools such as GTMetrix, ALEXA, THAT Web, and STAT Show shows the enhancement on the performance of academic journal websites. The results present that the journals with the natural science scopes have better performance than other journals with the more specific research areas. The credibility of journals was investigated through the number of citations on each journal. In this case, some of natural science journals show larger citations that those of social science journals. The diversification of the journal editors and reviewers on the natural science and social study remain less-heterogeneous. Based on the research findings, this research concludes that the academic journals at UIN Maulana Malik Ibrahim Malang need an improvement and more strategic ways to be indexed at the internationally indexed machines, such as Scopus and Thomson Reuters. By fulfilling the requirements that are obliged by those two index and citation brands, the academic journals at UIN Maulana Malik Ibrahim Malang can be internationally accredited. Therefore, there should be a good cooperation from the policy makers on the institutions with the academics, educational staffs and students to widely published their research articles. The next researchers can focus on the content consistency of academic writing that has less deep portion on this research.
Service-oriented architectures for devices - the SIRENA view

This paper outlines the perspectives opened by the application of the service-orientation paradigm for realizing high-level communications between next-generation, increasingly intelligent embedded devices - it indicates how this approach can benefit the manufacturing industry - it describes the approach adopted by the SIRENA project, as well as the business advantages it is expected to provide - and outlines early experimental results.
Blockchain for good

The blockchain innovation appears to represent viable catalysts for achieving global sustainable development targets. Projects and initiatives seeking to extend the reach of distributed ledger technologies (DLTs) seem mostly intended for the benefit of for-profit businesses, governments, and consumers. DLT projects devised for the public good could aim, in theory, to fulfill the United Nation’s current sustainable development goals. Blockchain technology is being applied in ways that could transform this ambition for good into a practical reality.
PRONOUNCIATION QUALITY OF JAVANESE OF ESL STUDENTS IN PRODUCING THE ENGSLSH SOUND: A CASE STUDY OF JAVANESE ESL STUDENTS IN TERITARY LEVEL

The quality of pronouncing English sounds by Javanese ESL students is much influenced by their way of speaking of their native language. The study aims to examine how Javanese ESL students shift their articulation in producing the English sounds. The data are Javanese ESL students’ speech of English in the forms of words, phrases, and sentences which are collected by means of recording, testing and participant interview. The data analysis applies techniques of comparison and contrast _between RP and Javanese ESL sounds_ in the domain of impressionistic articulatory phonetics which is assisted by using Audio Edit Magic (AEM). The result shows that Javanese ESL students produce consonant sounds by the lack of maximal force and tend to be lenis; while in pronouncing vowel sounds, they tend to produce some as its phonemes. This shifts the NSE/ FSE have perceived intelligibly is 53,8 %. This implies that Javanese ESL students’ shift in pronouncing the English sounds represented in words is still perceived and understood properly by the NSE/ FSE.
A boundary-value-free method for reconstructing electrical properties using MRI based on the Neumann-type integral formula

Recently, magnetic resonance electrical properties tomography (MREPT) has been actively studied as a method that reconstructs the electrical properties of biological tissues from internal magnetic field data measured by using MRI. We previously proposed an explicit reconstruction method for MREPT based on a D-bar equation of the electric field. In this method, as in some other conventional methods, EP values on the boundary of the region of interest (ROI) must be given as a Dirichlet boundary condition of the D-bar equation, which is not accessible in practical situations. Therefore, in this paper, we propose a novel method for reconstructing EPs in a circular region without boundary EP values. Starting from the integral solution of the D-bar equation in a circular region with the Neumann boundary condition, we show that the PDE is solved based only on magnetic field data measured by using MRI. Numerical simulations and a phantom experiment show that the proposed method yields a good reconstruction results without giving any boundary EP values.
Agriculture, land reform and development in South Africa : public policy for social upliftment

ABSTRAO The dislocation (within national borders) of indi~enous Africans from their land, represents one of the most tra~ic and explosive remnants of colonialism to befall the African continent. In recent times, the ~overnments of Zimbabwe, Namibia and South Africa (amon~ others) have been under immense pressure from their majority black population ~roups to address the 'land question' in an attempt to reverse the ne~ative outcomes of colonial exploitation.
The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity

Muscle LIM protein (MLP) is a cytoskeletal LIM-only protein expressed in striated muscle. Mutations in human MLP are associated with cardiomyopathy; however, the molecular mechanism by which MLP functions is not established. A Drosophila MLP homolog, mlp84B, displays many of the same features as the vertebrate protein, illustrating the utility of the fly for the study of MLP function. Animals lacking Mlp84B develop into larvae with a morphologically intact musculature, but the mutants arrest during pupation with impaired muscle function. Mlp84B displays muscle-specific expression and is a component of the Z-disc and nucleus. Preventing nuclear retention of Mlp84B does not affect its function, indicating that Mlp84B site of action is likely to be at the Z-disc. Within the Z-disc, Mlp84B is colocalized with the N-terminus of D-titin, a protein crucial for sarcomere organization and stretch mechanics. The mlp84B mutants phenotypically resemble weak D-titin mutants. Furthermore, reducing D-titin activity in the mlp84B background leads to pronounced enhancement of the mlp84B muscle defects and loss of muscle structural integrity. The genetic interactions between mlp84B and D-titin reveal a role for Mlp84B in maintaining muscle structural integrity that was not obvious from analysis of the mlp84B mutants themselves, and suggest Mlp84B and D-titin cooperate to stabilize muscle sarcomeres.
Increased Phagocytosis of Escherichia coli Pretreated with Subinhibitory Concentrations of Cyclacillin or Ampicillin

Abstract When incubated with subinhibitory concentrations of cyclacillin or ampicillin E. coli became more susceptible to subsequent phagocytosis by normal mouse monocytes (peritoneal exudate cells). Incubation for as little as 1 hr markedly increased the phagocytosis, which in turn was associated with increased intracellular killing of antibiotic-treated bacteria. Regardless of the length of time of incubation of the penicillin-resistant E. coli with potassium penicillin G there was no significant increase in phagocytosis.
Problems of Trajectory Building During Laser CNC Processing

The paper deals with the problems of trajectory building during laser computer numerical control (CNC) processing and presents a new approach to the optimization of the CNC tool trajectory during laser treatment of irregular shapes. The development of the firmware of the CNC machines encounters a number of problems, the most important of which is minimization of the processing time. Two main methods of time reduction are provided—by increasing speed of the treatment using smooth aliasing of acceleration/deceleration curves and reducing the number of auxiliary moves. The processing is represented as nodes, forming a terminating device trajectory. The CNC controller defines trajectory between the nodes, and the terminator is moved from node to node step-by-step. Decreasing the processing time is possible when the CNC tool is scanning paths to be processed and combine acceleration/deceleration curves to reach a maximum speed is considered. A genetic algorithm with crossover similar to the crossover used to solve the travelling salesman problem to reduce the number of auxiliary paths is proposed. The chromosomes formed by building blocks, each of them defining trajectory segments sequence and their orientation are compiling the used algorithm. To change the adjacent segments, heuristics is used so the path between ends of segment, hence the length of the auxiliary part, will be as short as possible.
Causative pathogens of severe diarrhea in children.

OBJECTIVES To investigate the enteropathogens in children with diarrhea attending Salmaniya Medical Complex, Bahrain. METHODS Fecal samples from 805 children up to 15 years were examined for parasites, ova and cysts by direct wet preparation, formol-ether concentration and modified Ziehl-Neelsen stain, during the period November 1998 through to June 2000. Samples were cultured for Salmonella, Shigella, Campylobacter and Enteropathogenic Escherichia coli. Antibiotic sensitivity tests were performed on the relevant clinical isolates by agar disk diffusion method. All stools from children below 3 years of age (653 samples) were processed for adenovirus and rotavirus using a commercially available latex agglutination test (Diarlex). In addition, reverse transcription-polymerase chain reaction was performed on 200 randomly selected samples using oligonucleotide primers for Rotavirus A, B and C. RESULTS Four subjects were found positive for parasites. Eighty-three (10.3%) samples were found positive for Salmonella (46 isolates), Shigella (26 isolates), Campylobacter jejuni (7 isolates), and Enteropathogenic Escherichia coli (4 isolates). Rotavirus was found in 91 (13.9%) samples and 4 samples (0.6%) were found positive for adenovirus. Out of 200 samples examined by reverse transcription-polymerase chain reaction, 73 (36.5%) were positive for group A rotavirus. CONCLUSIONS Rotavirus type A appeared to be the most common single agent in our pediatric population, followed by the classical bacterial pathogens. Adenovirus and parasites appeared to play a very minor role in diarrhea. Thus, we suggest the introduction of rotavirus diagnostic tests in microbiological examination of diarrheic stools of children below 3 years of age.
Investigations on antimycobacterial activity of some Ethiopian medicinal plants

Fifteen crude extracts prepared from seven Ethiopian medicinal plants used to treat various infectious diseases were assessed for their ability to inhibit the growth of Mycobacterium tuberculosis. A preliminary screening of the crude extracts against M. tuberculosis typus humanus (ATCC 27294) was done by dilution assay using Löwenstein–Jensen medium. None of the tested extracts except the acetone fraction obtained from the stem bark of Combretum molle (R. Br. ex G. Don.) Engl & Diels (Combretaceae) showed significant inhibitory action against this strain. The acetone fraction of the stem bark of C. molle caused complete inhibition at concentrations higher than 1 mg/mL. Phytochemical analysis of the bioactive fraction led to the isolation of a major tannin and two oleanane‐type pentacyclic triterpene glycosides. The tannin was identified as the ellagitannin, punicalagin, whilst the saponins were characterized as arjunglucoside (also called 4‐epi‐sericoside) and sericoside. All the pure compounds were further tested against the ATCC strain. Punicalagin was found to inhibit totally growth of the ATCC and also of a patient strain, which was fully sensitive to the standard antituberculosis drugs, at concentrations higher than 600 µg/mL and 1.2 mg/mL, respectively. On the other hand, the saponins failed to show any action on the ATCC strain. It appears that our findings are the first report of tannins exhibiting antimycobacterial activity. Copyright © 2001 John Wiley & Sons, Ltd.
U.S. wildfire governance as social-ecological problem

There are fundamental spatial and temporal disconnects between the specific policies that have been crafted to address our wildfire challenges. The biophysical changes in fuels, wildfire behavior, and climate have created a new set of conditions for which our wildfire governance system is poorly suited to address. To address these challenges, a reorientation of goals is needed to focus on creating an anticipatory wildfire governance system focused on social and ecological resilience. Key characteristics of this system could include the following: (1) not taking historical patterns as givens; (2) identifying future social and ecological thresholds of concern; (3) embracing diversity/heterogeneity as principles in ecological and social responses; and (4) incorporating learning among different scales of actors to create a scaffolded learning system.
A background subtraction based column-parallel analog-to-information converter for motion-triggered vision sensor

An analog-to-information converter (AIC) enables information quantization instead of signal quantization, which can reduce both quantization efforts and data bandwidth. Therefore, an AIC will relax data processing and transmission burden and improve overall power efficiency, making it attractive for wireless vision sensor networks. In this paper, we propose a background subtraction based column-parallel AIC for motion-triggered vision sensors. It features low-power and robust background subtraction for motion extraction as well as efficient information quantization. The AIC is implemented by integrating background subtraction with a successive-approximation-register and single-lope (SAR-SS) hybrid ADC using a new architecture. Targeting at scene interpretation applications, 6-bit background and 8-bit foreground are adopted. Simulation results show that vision data bandwidth and ADC power are reduced by 85.23% and 95.88% respectively when full-bit-depth motion images are required. The bandwidth reduction and the ADC power reduction can be further improved to 87.50% and 98.48% respectively if only binary motion images are needed.