Miracle-dz/UniFAR-FTUs huggingface dataset:
Measuring Implementation Fidelity

Over the past two decades, researchers and policy makers have increasingly emphasized the need to develop comprehensive evaluations to understand not only the outcomes produced by a program, but also the mechanisms and elements of a program that influence their outcomes. The assessment of implementation fidelity has been highlighted as critical to understanding how programs are implemented in efficacy studies as well as how programs are implemented as they transition from research settings into “real world” settings (Domitrovich & Greenberg, 2000; Durlak & DuPre, 2008; Dusenbury, Branningan, Falco, & Hansen, 2003; Harachi, Abbott, Catalano, Haggerty, & Felming, 1999). As such, procedures for documenting fidelity should be incorporated into program designs and fidelity measurement should be part of evaluation plans.
SoSharP: Recommending Sharing Policies in Multiuser Privacy Scenarios

Users often share information about others; sometimes this inadvertently violates others’ privacy. Thus, here the authors propose SoSharP, an agent-based approach to help users maintain their own and others’ privacy by guiding a selection of sharing policies in multiuser scenarios. SoSharP learns incrementally and asks for users’ input only when required, reducing users’ effort.
Censorship is f̶u̶t̶i̶l̶e̶ possible but difficult: A study in algorithmic ethnography

Discourse around censorship tends to be sensationalised in many quarters. Nabi (2014), for example, recently sought to “prove . the futility” of governments engaged in censorship programmes through the Streisand Effect (Greenberg, 2007). While most countries have an imperfect censorship regime, the sovereign rights of nations to make their own laws must be recognised, including (but not limited to) the protection of children, and the victims of child exploitation, gambling addicts, and Internet banking users, whose systems may be infected by malicious software, resulting in financial losses. The broader question to be posed seems to be, under what circumstances is censorship justified, and how can it best be achieved? In this paper, we present the results of a study that illustrates the overwhelming harms to users that emerge from an unregulated Internet regime: 89 percent of ads delivered to Canadian users on 5,000 rogue sites for the most complained-about movies and TV shows were classified as “high risk”. We conclude that more granular policies on what should be censored and better tools to enforce those policies are needed, rather than accepting that censorship is impossible.
Fra-1 et Fra-2 dans les cancers du sein triple négatifs : mécanismes transcriptionnels et identification de cibles thérapeutiques potentielles

Les cancers du sein triple negatifs (TNBC) ne beneficient d’aucune therapie ciblee et restent incurables. L’identification de nouvelles cibles moleculaires diagnostiques et surtout, therapeutiques constitue donc un enjeu majeur pour le traitement de ces cancers. Fra-1 et Fra-2, deux constituants du complexe transcriptionnel AP-1, sont surexprimes dans les TNBC ou ils participent a l’agressivite tumorale et/ou la metastatisation. Les genes cibles de Fra-1 et Fra-2, ainsi que les mecanismes moleculaires via lesquels ils gouvernent la transcription de leurs genes cibles sont tres peu caracterises. Dans ce contexte, l’objectif general de ma these a ete d’identifier les genes codants sous controle de Fra-1 et/ou Fra-2 et de caracteriser les sites de fixation de Fra-1 et Fra-2 sur la chromatine pour identifier des cibles directes, en combinant des approches transcriptomiques et genomiques combinees a l’interference a l’ARN dans la lignee modele MDA-MB231. Les resultats obtenus, associes a l’analyse de banques de donnees humaines, ont permis la selection de genes cibles pour les etudes mecanistiques et fonctionnelles. Le gene HMGA1, choisi en raison de son role maintenant bien etabli dans l’agressivite des tumeurs epitheliales, a fait l’objet d’une etude portant sur les mecanismes transcriptionnels gouvernes par Fra-1 et/ou Fra-2 pour sa regulation. L’etude fonctionnelle a ete focalisee sur CD68 dont l’expression est fortement induite par Fra-1 et Fra-2. CD68 code pour une proteine transmembranaire dont la fonction n’est pas clairement etablie et dont l’implication dans le phenotype tumoral n’a jamais ete etudiee.
Effects of a medicine review and education programme for older people in general practice.

AIMS To determine whether a medicine review and education programme influences the compliance and knowledge of older people in general practice. METHODS Older people taking at least three medicines were randomly allocated to a control or intervention group. Both groups received three visits from a clinical pharmacist: Visit 1: Assessment and patients' medicines rationalized in intervention group. Visit 2: Intervention group given medicines education. Visit 3: Knowledge and compliance in both groups assessed by structured questionnaire RESULTS Compliance in the intervention group was 91.3%, compared with 79.5% in the control group (P < 0.0001). The number of intervention group patients correctly understanding the purpose of their medicines increased from 58% to 88% on the second visit, compared with 67% to 70% in the control group (P < 0.0005). CONCLUSIONS A general practice based medication review and education programme improved medicine compliance and knowledge of older people in the short term.
Long-Term Effects of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Surgery on Type 2 Diabetes Mellitus in Morbidly Obese Subjects

Objective:To identify the rates and the predictors of long-term remission and the recurrence of type 2 diabetes mellitus (T2DM) after Roux-en-Y gastric bypass (RYGBP) or sleeve gastrectomy (SG). Background:The durability of the improvement of T2DM after bariatric surgery is not well characterized. Methods:One hundred fifty-three subjects with T2DM (RYGBP: n = 98; SG: n = 55) were evaluated for remission and recurrence of the disease throughout 35.4 ± 13.5 months' follow-up. The type of surgery, demographic, anthropometric, and biochemical parameters were ascertained as predictors of T2DM outcomes. Glucagon-like peptide 1 (GLP-1) responses after a standard mixed liquid meal were compared between patients presenting with T2DM remission after RYGBP or SG. Results:75.2% of subjects presented with remission of T2DM lasting at least 12 months. However, in 12.1% of subjects, T2DM recurred. Regression analysis showed a longer duration of T2DM (P = 0.006), a higher presurgical glycated hemoglobin level (P = 0.019), insulin treatment at baseline (P = 0.001), and a lower excess weight loss at last follow-up visit (P < 0.001) as independent predictors for the lack of T2DM remission. Insulin use before surgery (P = 0.005), an older age (P = 0.05), and weight regain after remission (P = 0.021) predicted recurrence of the disease. Long-term remission of T2DM after SG or RYGBP was associated with a comparably enlarged GLP-1 response to a standard mixed liquid meal challenge. Conclusions:Roux-en-Y gastric bypass and SG are associated with comparable remission rates of T2DM. However, insufficient weight loss or weight regain in those with a more advanced disease may hamper the benefits of these surgical techniques on T2DM.
A cross-layer scheme for multi-channel single-transceiver WiMax mesh networks

WiMax mesh network provides a mechanism for creating multi-hop mesh, which can be deployed as high speed wide area wireless network. The routing and scheduling are two key factors that influence the performance of the WiMax mesh networks. In this paper, we introduce cross-layer design scheme and take both routing and scheduling into account in order to improve the performance. A centralized scheduling and channel assignment algorithm, called Layered Critical Path (LCP), and a related routing construction algorithm based on cross-layer design are proposed for multi-channel single-transceiver WiMax mesh networks. The simulation result shows the cross-layer scheme can improve efficiently system performance.
Newspaper page decomposition using a split and merge approach

Indexing large newspaper archives requires automatic page decomposition algorithms with high accuracy. In this paper, we present our approach to an automatic page decomposition algorithm developed for the First International Newspaper Segmentation Contest. Our approach decomposes the newspaper image into image regions, horizontal and vertical lines, text regions and title areas. Experimental results are obtained from the data set of the contest.
Performance Improvement of Neural Network Based RLS Channel Estimators in MIMO-OFDM Systems

The objective of this study was tointroduce a recursive least squares (RLS) parameter estimatorenhanced by using a neural network (NN) to facilitate the computing of a bit error rate (BER) (error reduction) during channels estimation of a multiple input-multiple output orthogonal frequency division multiplexing (MIMO-OFDM) system over a Rayleigh multipath fading channel.Recursive least square is an efficient approach to neural network training:first, the neural network estimator learns to adapt to the channel variations then it estimates the channel frequency response. Simulation results show that the proposed method has better performance compared to the conventional methods least square (LS) and the original RLS and it is more robust at high speed mobility.
Setting the Stage for Social Change: Using Live Theater to Dispel Myths About Intimate Partner Violence

Research has demonstrated the ability of fictional narratives to educate about social and health issues. Although some entertainment-education efforts have used live theater as a mechanism for social change, very few use social science methods to demonstrate exposure effects. This project used live theater to increase understanding and knowledge about intimate partner violence, a pervasive and costly social and health problem. Audiences watched either a play about abusive relationships—emphasizing psychological abuse and the role of coercion and control—or a control play. Compared with controls, those who watched the abuse play were more knowledgeable and less accepting of myths about abusive relationships in a way that mirrored play content. Although both plays were highly transporting, transportation did not explain a significant amount of variance in the attitudes toward intimate partner violence. These results provide rare evidence for theater as a tool for social change.
COMPASS: a program for generating serial samples under an infinite sites model

SUMMARY The program COMPASS can generate samples that have been collected at various points in time from a population that is evolving according to a Wright-Fisher model. The samples are generated using coalescence simulations permitting various demographic scenarios and the program uses an infinite sites model to generate polymorphism data for the samples. By generating serially sampled population-genetic data, COMPASS allows investigating properties of polymorphism data that has been collected at different time points, and aid in making inference from ancient polymorphism data. AVAILABILITY The program and the manual are available at: http://www.egs. uu.se/evbiol/Research/JakobssonLab/compass.html CONTACT mattias.jakobsson@ebc.uu.se.
Fault-tolerant control of nonlinear system

The design strategies of fault-tolerant control system (FTCS) are developed. In the paper, the online fault-tolerant control (FTC) scheme is developed based on the fuzzy logic system. The closed-loop stability is established based on Lyapunovs sense. The resulting closed-loop system is stable by using the corrective control law. Compared with the existing results, the fault is accommodated by the fault compensator. The updating control law is so derived that all the parameters of the closed-loop system are bounded. The advantage of fault compensation is the dynamics caused by faults that can be accommodated online. Examples of the proposed design indicate that the approaches are effective.
Lutein: A Valuable Ingredient of Fruit and Vegetables

Lutein is a human serum carotenoid which is not synthesized by humans and thus must be obtained by the ingestion of food containing it such as fruits and vegetables. Lutein is present in different forms in those foods as all-trans-lutein, cis-lutein, epoxi-lutein, and lutein linked to proteins. It discusses if the intake of lutein or diets supplemented with lutein or diets rich in fruits and vegetables are important in the prevention of diseases like some cancers, cardiovascular diseases, etc., that may be affected by the antioxidant effect of lutein; or in the prevention of age-related macular degeneration and other eye diseases. The concentration of lutein in fruits and vegetables depends on the species. We've included the concentration of lutein in 74 species reported by different authors since 1990. Currently the quantification of lutein is mainly performed by HPLC, but more investigations into a quantification method for lutein, lutein isomers, and epoxi-lutein are necessary. Improvement of lutein extraction methods is important as well. Methods commonly used in the vegetable and fruit industry like heat treatment, storage conditions, etc. can change lutein concentrations; other factors depend on the plant, for instance the variety, the stage of maturity, etc.
Prevention of beta-lactam-associated diarrhea by Saccharomyces boulardii compared with placebo.

OBJECTIVES To determine the safety and efficacy of a new preventive agent for antibiotic-associated diarrhea (AAD) in patients receiving at least one beta-lactam antibiotic. METHODS A double-blinded, placebo-controlled, parallel group study was performed in a high-risk group of hospitalized patients receiving a new prescription for a beta-lactam antibiotic and having no acute diarrhea on enrollment. Lyophilized Saccharomyces boulardii or placebo (1 g/day) was given within 72 h of the start of the antibiotic(s) and continued until 3 days after the antibiotic was discontinued, after which the patients were followed for 7 wk. RESULTS Of the 193 eligible patients, significantly fewer, 7/97 (7.2%), patients receiving S. boulardii developed AAD compared with 14/96 (14.6%) on placebo (p = 0.02). The efficacy of S. boulardii for the prevention of AAD was 51%. Using a multivariate model to adjust for two independent risk factors for AAD (age and days of cephalosporin use), the adjusted relative risk was significantly protective for S. boulardii (RR = 0.29, 95% CI = 0.08, 0.98). CONCLUSION The prophylactic use of S. boulardii given with a beta-lactam antibiotic resulted in a significant reduction of AAD with no serious adverse reactions.
More “mapping” in brain mapping: Statistical comparison of effects

The term “mapping” in the context of brain imaging conveys to most the concept of localization; that is, a brain map is meant to reveal a relationship between some condition or parameter and specific sites within the brain. However, in reality, conventional voxel‐based maps of brain function, or for that matter of brain structure, are generally constructed using analyses that yield no basis for inferences regarding the spatial nonuniformity of the effects. In the normal analysis path for functional images, for example, there is nowhere a statistical comparison of the observed effect in any voxel relative to that in any other voxel. Under these circumstances, strictly speaking, the presence of significant activation serves as a legitimate basis only for inferences about the brain as a unit. In their discussion of results, investigators rarely are content to confirm the brain's role, and instead generally prefer to interpret the spatial patterns they have observed. Since “pattern” implies nonuniform effects over the map, this is equivalent to interpreting results without bothering to test their significance, a practice most of the experimentally‐trained would eschew in other contexts. In this review, we appeal to investigators to adopt a new standard of data presentation that facilitates comparison of effects across the map. Evidence for sufficient effect size difference between the effects in structures of interest should be a prerequisite to the interpretation of spatial patterns of activation. Hum. Brain Mapping 19:90–95, 2003. © 2003 Wiley‐Liss, Inc.
On-chip fabrication of well-aligned and contact-barrier-free GaN nanobridge devices with ultrahigh photocurrent responsivity.

In the last two decades, a wide range of semiconductor nanowires have been synthesized and used as building blocks for the development of a new generation of electronic and optoelectronic devices. [1–8] The integration of these nanowires into the thin-film-based microchip has become a critical problem in the practical application of the nanomaterial properties and for industrial manufacture. Single-wire-based devices have been shown to possess novel properties and provide a major platform for fundamental research. [9–13] However, the conventional fabrication of single-wire devices by the ‘‘pick and place’’ method is rather complicated and uneconomic, which is unsuitable for large-scale manufacturing. In contrast, devices based on an ensemble of nanowires are much easier to fabricate, thus reducing the barriers to practical applications. A method based on the bridging concept and showing the potential to directly integrate an ensemble of nanowires onchip was first demonstrated by Haraguchi et al. [14] Different from the traditional ‘‘bottom-up growth and then top-down processing’’, the nanowires are laterally grown across a trench and suspended between two film posts as nanobridges (NBs). [14–26] As the main device architecture and electrodes can be designed and prepared prior to NB growth, nanomaterial deterioration due to the post treatment in the
Obesity and Type 2 Diabetes Mellitus

The global obesity epidemic is showing no signs of abating, and is fuelling an explosion in numbers of Type 2 Diabetes Mellitus (T2D) worldwide. Despite clear epidemiological and pathophysiological links between obesity and T2D, the actual mechanisms are complex given that some people with obesity appear to be protected in some way from developing T2D, and T2D can develop in a minority of lean people. Obesity and T2D form part of the metabolic syndrome, which combined with hypertension and dyslipidaemia result in premature mortality from cardiovascular disease in millions of people globally each year. Long-term microvascular sequelae from T2D and multiple co-morbidities associated with obesity (including psychological, musculoskeletal, respiratory and reproductive) also have a major adverse impact on quality of life and pose an enormous fiscal burden on global health authorities. Major factors contributing towards ‘diabesity’ include chronic overconsumption of energy-dense foods and lack of physical activity. Recently, it was recognized that T2D is characterized by impaired fat metabolism in addition to glucotoxicity. Overconsumption of energy-dense foods results in excessive fat deposition and enhanced insulin resistance. Free fatty acids (FFAs) delivered to the liver via the portal vein result in fatty liver. FFAs spill into the systemic circulation resulting in lipotoxicity of organs such as pancreas, heart and muscles initiating a viscous cycle of fat damage, inflammation, worsening insulin resistance and beta cell insulin secretion, and ultimately manifestation of T2D. Visceral fat content is an independent predictor of insulin resistance, whilst adipokines such as adiponectin protect against obesity-induced T2D. Further study of the precise mechanisms of lipotoxicity in the development of T2D will enable development of novel strategies to manage and eventually prevent onset of T2D in the context of obesity. In this brief review article, we discuss the currently-understood intricate associations between obesity and T2D and options for management.
Complex percutaneous extraction of a 15-year-old atrial lead dislodged into the subclavian vein

We present a case of a 50-year-old patient with DDD pacing failure who underwent atrial lead extraction. The lead was implanted 15 years ago, and 4 months ago it dislodged into the subclavian vein following a fracture. The lead was removed via the femoral vein approach using a Cook Medical device (Byrd Femoral Workstation, Dotter basket) and pigtail catheter.
Design and Simulation of a Radio over Fiber System with Chromatic Dispersion and Polarisation Mode Dispersion Compensation

Radio over Fiber (ROF) is an innovating technology that provides provision for the flourishment of broadband wireless service which combines robust transport technologies and flexible optical routing. ROF is an integration of wireless and fiber optic networks, which has a range of applications including last mile solutions, extension of existing radio coverage and capacity, etc. A Nematic type LCPCF (Liquid Crystal Photonic Crystal Fiber) is used, which has low loss, light weight, large bandwidth characteristics, small size and low cable cost which makes it ideal and most flexible solution for efficiently transporting radio signals to remotely located antenna sites in a wireless network. Equalization techniques are considered for electronic compensation of Chromatic Dispersion (CD) and Polarization Mode Dispersion (PMD) in a dually polarized coherent ROF communication system.
Customizing anticancer strategies to local needs.

W orldwide, the number of cancer cases each year could reach 27 million by 2030, and more than half of those will most likely occur in lowand middle-income countries, according to the World Health Organization’s World Cancer Report 2008 . Until recently, national cancer control efforts tended to focus on isolated goals: tobacco cessation programs, more radiotherapy machines, or extending the availability of Pap and other screening tests. But in the last several years, the focus has shifted to integrating such efforts into larger national cancer plans that build policy, infrastructure, and resources on the basis of an individual nation’s needs. “Probably the best weapon we have to deal with the world cancer crisis is to have a national cancer plan developed in each country,” said Franco Cavalli, M.D. , medical director of the Oncology Institute of Southern Switzerland and immediate past president of the International Union Against Cancer. Such a document provides a framework for each country to assess its cancer needs and look for solutions. But even with growing recognition of the global cancer problem, few developing countries have national cancer control plans. And when they do, they typically have large gaps in information, resources, and infrastructure. The key to success, experts say, will be to help individual countries build cancer control programs that are self-supporting and based on their individual needs and resources.