Miracle-dz/UniFAR-FTUs huggingface dataset:
Universal translational velocity of vortex rings behind conical objects

Ring vortices are efficient at transporting fluid. They are often produced by ejecting a volume of fluid through a circular orifice. The impulse given to the vortex rings results in a propulsive force on the generator. Propulsive vortex rings have been widely studied and characterised. After four convective times, the vortex moves faster than the shear layer it originates from, and separates. This separation corresponds to a maximum in circulation and a maximal spread of the vorticity, quantified by the non-dimensional energy. The simultaneity of these three events obfuscates the causality between them. To analyse the temporal evolution of the non-dimensional energy of ring vortices independent of their separation, we analyse the development of vortices generated in the wake of cones. Cones with different apertures and diameters were accelerated from rest to produce a wide variety of vortex rings and their energy, circulation, and velocity were extracted based on time-resolved velocity field measurements. The rings that form behind the cones have a self-induced velocity that causes them to follow the cone and they continue to grow as the cone travels well beyond the limiting vortex formation times scales observed for propulsive vortices. The non-dimensional circulation, based on the vortex diameter, and the non-dimensional energy of the drag vortex rings converge after three convective times to values comparable to their propulsive counterparts. This result proves that vortex pinch-off does not cause the non-dimensional energy to reach a minimum value. The limiting values of the non-dimensional circulation and energy are mostly independent of the cone geometry and translational velocity and fall within an interval of 10% around the mean value. With only 6% of variation, the velocity of the vortex is the most unifying quantity that governs the formation of vortex rings behind cones.
Exploring the Hierarchy in Relation Labels for Scene Graph Generation

By assigning each relationship a single label, current approaches formulate the relationship detection as a classification problem. Under this formulation, predicate categories are treated as completely different classes. However, different from the object labels where different classes have explicit boundaries, predicates usually have overlaps in their semantic meanings. For example, sit\_on and stand\_on have common meanings in vertical relationships but different details of how these two objects are vertically placed. In order to leverage the inherent structures of the predicate categories, we propose to first build the language hierarchy and then utilize the Hierarchy Guided Feature Learning (HGFL) strategy to learn better region features of both the coarse-grained level and the fine-grained level. Besides, we also propose the Hierarchy Guided Module (HGM) to utilize the coarse-grained level to guide the learning of fine-grained level features. Experiments show that the proposed simple yet effective method can improve several state-of-the-art baselines by a large margin (up to $33\%$ relative gain) in terms of Recall@50 on the task of Scene Graph Generation in different datasets.
Interactive Focus+Context Rendering for Hexahedral Mesh Inspection

The visual inspection of a hexahedral mesh with respect to element quality is difficult due to clutter and occlusions that are produced when rendering all element faces or their edges simultaneously. Current approaches overcome this problem by using focus on specific elements that are then rendered opaque, and carving away all elements occluding their view. In this work, we make use of advanced GPU shader functionality to generate a focus+context rendering that highlights the elements in a selected region and simultaneously conveys the global mesh structure and deformation field. To achieve this, we propose a gradual transition from edge-based focus rendering to volumetric context rendering, by combining fragment shader-based edge and face rendering with per-pixel fragment lists. A fragment shader smoothly transitions between wireframe and face-based rendering, including focus-dependent rendering style and depth-dependent edge thickness and halos, and per-pixel fragment lists are used to blend fragments in correct visibility order. To maintain the global mesh structure in the context regions, we propose a new method to construct a sheet-based level-of-detail hierarchy and smoothly blend it with volumetric information. The user guides the exploration process by moving a lens-like hotspot. Since all operations are performed on the GPU, interactive frame rates are achieved even for large meshes.
Robust Design for Intelligent Reflecting Surface Assisted MIMO-OFDMA Terahertz Communications

Recently, terahertz (THz) communication has drawn considerable attention as one of the promising technologies for the future wireless communications owning to its ultra-wide bandwidth. Nonetheless, one major obstacle that prevents the actual deployment of THz lies in its inherent huge attenuation. Intelligent reflecting surface (IRS) and multiple-input multiple-output (MIMO) represent two effective solutions for compensating the large pathloss in THz systems. In this paper, we consider an IRS-aided multi-user THz MIMO system with orthogonal frequency division multiple access, where the sparse radio frequency chain antenna structure is adopted for reducing the power consumption. The objective is to maximize the weighted sum rate via jointly optimizing the hybrid analog/digital beamforming at the base station and reflection matrix at the IRS. {Since the analog beamforming and reflection matrix need to cater all users and subcarriers, it is difficult to directly solve the formulated problem, and thus, an alternatively iterative optimization algorithm is proposed. } Specifically, the analog beamforming is designed by solving a MIMO capacity maximization problem, while the digital beamforming and reflection matrix optimization are both tackled using semidefinite relaxation technique. Considering that obtaining perfect channel state information (CSI) is a challenging task in IRS-based systems, we further explore the case with the imperfect CSI for the channels from the IRS to users. Under this setup, we propose a robust beamforming and reflection matrix design scheme for the originally formulated non-convex optimization problem. Finally, simulation results are presented to demonstrate the effectiveness of the proposed algorithms.
Dynamic analysis of tapping-mode AFM with sidewall probe subjected to effects of probe mass and sidewall extension

Atomic Force Microscopy with SideWall (AFM SW) is widely used for nano-scale surface measurements at side surfaces. In the current study, by taking into consideration the effects of sidewall beam and its probe, an analytical method is developed to explore the dynamics of AFM-SW. The effect of probe mass, sidewall extension length, and tip sample interactions on the resonance frequencies and amplitude of Micro-Cantilever is widely investigated. The obtained results of the analytical model demonstrate the significant effect of these parameters on the dynamics of AFM-SW. To verify the accuracy of the analytical model, the obtained results are compared against the simulation data of previously published works and a good agreement is observed. Resonance Frequency (RF) of cantilever clearly declines when the mass of probe is taken to account, especially in higher RFs. Besides, probe effect on RF is higher when sidewall beam is longer. Resonance frequency decreases when tip-sample interaction or probe mass is high, yet the amount of reduction is intensified when probe mass and interaction together are at higher point. An analytical method is developed to explore the dynamics of Atomic Force Microscopy with considering SideWall beam effects (AFM-SW). The effect of probe mass, sidewall extension length, and tip sample interactions on vibration of micro-cantilever is investigated. The obtained results are compared with previous literatures. The results show that Resonance Frequency (RF) of cantilever declines when the mass of probe is taken to account. Besides, probe effect on RF is higher when sidewall beam is longer. Resonance frequency decreases when tip-sample interaction or probe mass is high, yet the amount of reduction is intensified when they are at higher point.
Fast high-fidelity multiqubit state transfer with long-range interactions

We describe an efficient protocol to perform quantum state transfer using Hamiltonian dynamics with long-range interactions. The time to transfer $n$ qubits a sufficiently large distance is proportional to $\sqrt{n}$. Even without error correction, the fidelity of this multi-qubit state transfer process remains finite for arbitrarily well-separated qubits in the presence of uncorrelated random errors in coupling constants.
Carousel Personalization in Music Streaming Apps with Contextual Bandits

Media services providers, such as music streaming platforms, frequently leverage swipeable carousels to recommend personalized content to their users. However, selecting the most relevant items (albums, artists, playlists.) to display in these carousels is a challenging task, as items are numerous and as users have different preferences. In this paper, we model carousel personalization as a contextual multi-armed bandit problem with multiple plays, stochastic arm display and delayed batch feedback. We empirically show the effectiveness of our framework at capturing characteristics of real-world carousels by addressing a large-scale playlist recommendation task on a global music streaming mobile app. Along with this paper, we publicly release industrial data from our experiments, as well as an open-source environment to simulate comparable carousel personalization learning problems.
Galaxy and Mass Assembly (GAMA): A WISE Study of the Activity of Emission-line Systems in G23

We present a detailed study of emission-line systems in the Galaxy And Mass Assembly (GAMA) G23 region, making use of Wide-field Infrared Survey Explorer (WISE) photometry that includes carefully measured resolved sources. After applying several cuts to the initial catalog of ∼41,000 galaxies, we extract a sample of 9809 galaxies. We then compare the spectral diagnostic Baldwin, Philips & Terlevich (BPT) classification of 1154 emission-line galaxies (38% resolved in W1) to their location in the WISE color–color diagram, leading to the creation of a new zone for mid-infrared “warm” galaxies located 2σ above the star-forming sequence, below the standard WISE active galactic nucleus (AGN) region. We find that the BPT and WISE diagrams agree on the classification for 85% and 8% of the galaxies as non-AGN (star-forming = SF) and AGN, respectively, and disagree on ∼7% of the entire classified sample. Thirty-nine percent of the AGNs (all types) are broad-line systems for which the [N ii] and [Hα] fluxes can barely be disentangled, giving in most cases spurious [N ii]/[Hα] flux ratios. However, several optical AGNs appear to be completely consistent with SF in WISE. We argue that these could be low-power AGNs, or systems whose hosts dominate the IR emission. Alternatively, given the sometimes high [O iii] luminosity in these galaxies, the emission lines may be generated by shocks coming from super-winds associated with SF rather than AGN activity. Based on our findings, we have created a new diagnostic: [W1 – W2] versus [N ii]/[Hα], which has the virtue of separating SF from AGNs and high-excitation sources. It classifies 3 to ∼5 times more galaxies than the classic BPT.
Long noncoding RNA TTN-AS1 promotes breast cancer cell migration and invasion via sponging miR-140-5p

Objectives Breast cancer (BC) is one of the most ordinary fatal cancers. Recent studies have identified the vital role of long noncoding RNAs (lncRNAs) in the development and progression of BC. In this research, lncRNA TTN-AS1 was studied to identify how it functioned in the metastasis of BC.Methods TTN-AS1 expression of tissues was detected by RT-qPCR in 56 BC patients. Wound healing assay and transwell assay were used to observe the biological behavior changes of BC cells through gain or loss of TTN-AS1. In addition, luciferase assays and RNA immunoprecipitation (RIP) assay were performed to discover the potential targets of TTN-AS1 in BC cells.Results TTN-AS1 expression level in BC samples was higher than that of adjacent ones. Besides, cell migrated ability and cell invaded ability of BC cells were inhibited after TTN-AS1 was silenced. Cell migrated ability and cell invaded ability of BC cells were promoted after TTN-AS1 was overexpressed. In addition, miR-140-5p was upregulated after silence of TTN-AS1 in BC cells, while miR-140-5p was downregulated after overexpression of TTN-AS1 in BC cells. Furthermore, luciferase assays and RNA immunoprecipitation assay (RIP) showed that miR-140-5p was a direct target of TTN-AS1 in BC.Conclusion Our study uncovers a new oncogene in BC and suggests that TTN-AS1 could enhance BC cell migration and invasion via sponging miR-140-5p, which provides a novel therapeutic target for BC patients.
Reduced Attentional Control in Older Adults Leads to Deficits in Flexible Prioritization of Visual Working Memory

Visual working memory (VWM) resources have been shown to be flexibly distributed according to item priority. This flexible allocation of resources may depend on attentional control, an executive function known to decline with age. In this study, we sought to determine how age differences in attentional control affect VWM performance when attention is flexibly allocated amongst targets of varying priority. Participants performed a delayed-recall task wherein item priority was varied. Error was modelled using a three-component mixture model to probe different aspects of performance (precision, guess-rate, and non-target errors). The flexible resource model offered a good fit to the data from both age groups, but older adults showed consistently lower precision and higher guess rates. Importantly, when demands on flexible resource allocation were highest, older adults showed more non-target errors, often swapping in the item that had a higher priority at encoding. Taken together, these results suggest that the ability to flexibly allocate attention in VWM is largely maintained with age, but older adults are less precise overall and sometimes swap in salient, but no longer relevant, items possibly due to their lessened ability to inhibit previously attended information.
The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Directly Enhances the Contractile Recovery of Mouse Hearts at a Concentration Equivalent to that Achieved with Standard Dosing in Humans

Despite a similar mechanism of action underlying their glucose-lowering effects in type 2 diabetes, dipeptidyl peptidase-4 (DPP-4) inhibitors have diverse molecular structures, raising the prospect of agent-specific, glucose-independent actions. To explore the issue of possible DPP-4 inhibitor cardiac heterogeneity, we perfused different DPP-4 inhibitors to beating mouse hearts ex vivo, at concentrations equivalent to peak plasma levels achieved in humans with standard dosing. We studied male and female mice, young non-diabetic mice, and aged diabetic high fat diet-fed mice and observed that linagliptin enhanced recovery after ischemia-reperfusion, whereas sitagliptin, alogliptin, and saxagliptin did not. DPP-4 transcripts were not detected in adult mouse cardiomyocytes by RNA sequencing and the addition of linagliptin caused ≤0.2% of cardiomyocyte genes to be differentially expressed. In contrast, incubation of C166 endothelial cells with linagliptin induced cell signaling characterized by phosphorylation of Akt and endothelial nitric oxide synthase, whereas the nitric oxide (NO) donor, S-nitroso-N-acetylpenicillamine increased serine 16 phosphorylation of the calcium regulatory protein, phospholamban in cardiomyocytes. Furthermore, linagliptin increased cardiomyocyte cGMP when cells were co-cultured with C166 endothelial cells, but not when cardiomyocytes were cultured alone. Thus, at a concentration comparable to that achieved in patients, linagliptin has direct effects on mouse hearts. The effects of linagliptin on cardiomyocytes are likely to be either off-target or indirect, mediated through NO generation by the adjacent cardiac endothelium.
The Importance of Breast Adipose Tissue in Breast Cancer

Adipose tissue is a complex endocrine organ, with a role in obesity and cancer. Adipose tissue is generally linked to excessive body fat, and it is well known that the female breast is rich in adipose tissue. Hence, one can wonder: what is the role of adipose tissue in the breast and why is it required? Adipose tissue as an organ consists of adipocytes, an extracellular matrix (ECM) and immune cells, with a significant role in the dynamics of breast changes throughout the life span of a female breast from puberty, pregnancy, lactation and involution. In this review, we will discuss the importance of breast adipose tissue in breast development and its involvement in breast changes happening during pregnancy, lactation and involution. We will focus on understanding the biology of breast adipose tissue, with an overview on its involvement in the various steps of breast cancer development and progression. The interaction between the breast adipose tissue surrounding cancer cells and vice-versa modifies the tumor microenvironment in favor of cancer. Understanding this mutual interaction and the role of breast adipose tissue in the tumor microenvironment could potentially raise the possibility of overcoming breast adipose tissue mediated resistance to therapies and finding novel candidates to target breast cancer.
Putting the Spring back into the Hare (Pedetes capensis): Meat Chemical Composition of an Underutilized Protein Source

Alternative protein sources are gaining increasing global attention as a solution to address future protein demands. Determining the chemical composition of meat alternatives is vital to confirm that it is nutritious, but also to increase product value and promote its utilization. The carcass characteristics and chemical composition of springhare, an underutilized protein source, was found to be comparable to that of commercially reared rabbits. Hence, its introduction into the commercial supply chain would likely not offset consumers accustomed to purchasing rabbit/hare meat. Springhare meat had a high protein content (~22.5 g/100 g meat) and low lipid (<1.3 g/100 g meat) content. The meat’s fatty acids mainly comprised C18:2n6c (γ-linoleic acid; 24%), C18:0 (stearic acid; 20%), C16:0 (palmitic acid; 19%), C20:4n6 (arachidonic acid; 15%) and C18:1n9c (oleic acid; 13%). Although sex did not significantly influence the carcass characteristics and meat composition, season did have an effect (p < 0.05) on the fatty acid profile. The meat harvested in summer had higher (p < 0.05) concentrations of favorable unsaturated fatty acids, C18:2n6c, C18:3n6, C18:3n3 (α-linolenic acid), C20:2n6 (eicosadienoic acid), C20:3n3 (eicosatrienoic acid), compared to the meat obtained in winter, which contained more (p < 0.05) saturated fatty acids. The results verify that springhare can be utilized as a viable alternative protein source.
Genomic Islands in Mycoplasmas

Bacteria of the Mycoplasma genus are characterized by the lack of a cell-wall, the use of UGA as tryptophan codon instead of a universal stop, and their simplified metabolic pathways. Most of these features are due to the small-size and limited-content of their genomes (580–1840 Kbp; 482–2050 CDS). Yet, the Mycoplasma genus encompasses over 200 species living in close contact with a wide range of animal hosts and man. These include pathogens, pathobionts, or commensals that have retained the full capacity to synthesize DNA, RNA, and all proteins required to sustain a parasitic life-style, with most being able to grow under laboratory conditions without host cells. Over the last 10 years, comparative genome analyses of multiple species and strains unveiled some of the dynamics of mycoplasma genomes. This review summarizes our current knowledge of genomic islands (GIs) found in mycoplasmas, with a focus on pathogenicity islands, integrative and conjugative elements (ICEs), and prophages. Here, we discuss how GIs contribute to the dynamics of mycoplasma genomes and how they participate in the evolution of these minimal organisms.
Standing up against office sitting: A study protocol

Background Sedentary behaviour is associated with cardiometabolic diseases amongst office-bound workers, mostly through extended sitting and engaging in low-energy-demanding activities during work hours. The aim of this study is to assess the effectiveness of standing desks and healthy messages on cardiovascular parameters in a cohort of office-based workers and to explore the perceptions of these workers about the suitability of this intervention to lower occupation-related sedentariness. Methods/design The protocol will use a mixed-methods study design. Phase 1 of this study is a 12-month, single blinded, randomised controlled trial, which will include baseline, 3-month, 6-month and 12-month post-intervention assessments of plausible cardiometabolic risk biomarkers in office-bound workers at a South African credit and information management company. These biomarkers include anthropometry, sedentary behaviour and physical activity, sleep duration, blood pressure, glucose, glycated haemoglobin (HbA1c), lipid profile and cardiorespiratory fitness. Participants will be randomised into an intervention or control group. The intervention group will be provided with an adjustable sit–stand desk and receive weekly health-promoting messages for the intervention period. Phase 2 will use focus group discussions conducted post-intervention to explore the study participants’ perceptions of the effectiveness of the intervention. Cardiometabolic risk biomarkers and changes in these variables will be compared between the intervention group and the control group at the four time points using descriptive and inferential statistics. Discussion Regression analysis will be undertaken to determine the association of cardiometabolic risk biomarkers with cardiometabolic diseases. A thematic content analysis approach will be used to explore emerging themes from focus group discussions. Protocol identification Pan African Clinical Trial Registry, PACTR201911656014962.