Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects on Fatty Acid Metabolism of a New Powdered Human Milk Fortifier Containing Medium-Chain Triacylglycerols and Docosahexaenoic Acid in Preterm Infants

Preterm infants require fortification of human milk (HM) with essential fatty acids (FA) to ensure adequate post-natal development. As part of a larger randomized controlled study, we investigated FA metabolism in a subset of 47 clinically stable preterm infants (birth weight ≤1500 g or gestational age ≤32 weeks). Infants were randomized to receive HM supplemented with either a new HM fortifier (nHMF; n = 26) containing 12.5 g medium-chain FA (MCFA), 958 mg linoleic acid (LA), 417 mg α-linolenic acid (ALA), and 157 mg docosahexaenoic acid (DHA) per 100 g of powder (in compliance with the latest guidelines) or a fat-free HMF (cHMF; n = 21). Plasma phospholipid (PL) and triacylglycerol (TAG), and red blood cell phosphatidylcholine (RBC-PC) and phosphatidylethanolamine (RBC-PE) FA profiles were assessed before and after 21 days of feeding. In the nHMF group, significantly increased levels of n-9 monounsaturated fatty acids were observed, formed most likely by elongation and desaturation of dietary saturated fatty acids present in HM. ALA fortification increased ALA assimilation into plasma TAG. Similarly, DHA fortification enriched the DHA content in RBC-PE, which, in this compartment, was not associated with lower arachidonic acid levels as observed in plasma TAG and phospholipids. RBC-PE, a reliable indicator of FA metabolism and accretion, was the most sensitive compartment in this study.
Is prenatal sex selection associated with lower female child mortality?

I examine whether prenatal sex selection has substituted postnatal excess female mortality by analysing the dynamics of child sex ratios between 1980 and 2015 using country-level life table data. I decompose changes in child sex ratios into a ‘fertility’ component attributable to prenatal sex selection and a ‘mortality’ component attributable to sex differentials in postnatal survival. Although reductions in numbers of excess female deaths have accompanied increases in missing female births in all countries experiencing the emergence of prenatal sex selection, relative excess female mortality has persisted in some countries but not others. In South Korea, Armenia, and Azerbaijan, mortality reductions favouring girls accompanied increases in prenatal sex selection. In India, excess female mortality was much higher and largely stable as prenatal sex selection emerged, but slight reductions were seen in the 2000s. In China, although absolute measures showed reductions, relative excess female mortality persisted as prenatal sex selection increased.
LDA Based Feature Selection for Document Clustering

In this paper, we propose a novel model for text document clustering. Usually, Text documents consist of a vast number of features. We selected important features through four methods term variance, document frequency, Latent Dirichlet Allocation, and Significance methods. We demonstrated the effectiveness of proposed model on 20NG and WebKB datasets which are publicly available. We evaluated the model with F-Score value. Results indicate that LDA performed best in capturing the discriminate features.
Analysis of descriptors relevant to image search by content

This article investigates the relevance of visual descriptors in content based search. We propose an approach of indexing and searching of images by content based on the extraction of different vectors characteristic of remote sensing images decomposed into wavelets [6]. It is shown that the Coiflets-3 have better performances in terms of results and computation time for images with a strong directional predominance. It is shown that the Daubechies-3 and Symmlet-3 wavelets show better results on asymmetric or random images. The results of this work are compared with previous work and show a clear improvement.
The Importance of Sex Stratification in Autoimmune Disease Biomarker Research: A Systematic Review

The immune system is highly dynamic and regulated by many baseline characteristic factors. As such, significant variability may exist among different patient groups suffering from the same autoimmune disease (AD). However, contemporary research practices tend to take the reductionist aggregate approach: they do not segment AD patients before embarking on biomarker discovery. This approach has been productive: many novel AD biomarkers have recently been discovered. Yet, subsequent validation studies of these biomarkers tend to suffer from a lack of specificity, sensitivity, and reproducibility which hamper their translation for clinical use. To enhance reproducibility in validation studies, an optimal discovery-phase study design is paramount: one which takes into account different parameters affecting the immune system biology. In this systematic review, we highlight need for stratification in one such parameter, i.e., sex stratification. We will first explore sex differences in immune system biology and AD prevalence, followed by reported sex-bias in the clinical phenotypes of two ADs—one which more commonly affects females: systemic lupus erythematosus, and one which more commonly affects males: ankylosing spondylitis. The practice of sex stratification in biomarker research may not only advance the discovery of sex-specific AD biomarkers but more importantly, promote reproducibility in subsequent validation studies, thus easing the translation of these novel biomarkers from bench to bedside to improve AD diagnosis. In addition, such practice will also promote deeper understanding for differential AD pathophysiology in males and females, which will be useful for the development of more effective interventions for each sex type.
Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer

Abstract Adenosine-to-inosine (A-to-I) RNA editing entails the enzymatic deamination of adenosines to inosines by adenosine deaminases acting on RNA (ADARs). Dysregulated A-to-I editing has been implicated in various diseases, including cancers. However, the precise factors governing the A-to-I editing and their physiopathological implications remain as a long-standing question. Herein, we unravel that DEAH box helicase 9 (DHX9), at least partially dependent of its helicase activity, functions as a bidirectional regulator of A-to-I editing in cancer cells. Intriguingly, the ADAR substrate specificity determines the opposing effects of DHX9 on editing as DHX9 silencing preferentially represses editing of ADAR1-specific substrates, whereas augments ADAR2-specific substrate editing. Analysis of 11 cancer types from The Cancer Genome Atlas (TCGA) reveals a striking overexpression of DHX9 in tumors. Further, tumorigenicity studies demonstrate a helicase-dependent oncogenic role of DHX9 in cancer development. In sum, DHX9 constitutes a bidirectional regulatory mode in A-to-I editing, which is in part responsible for the dysregulated editome profile in cancer.
The Ridesharing Revolution : Economic Survey and Synthesis

Digital ridesharing platforms, such as Uber and Lyft, are part of a broader suite of innovations that constitute what is sometimes referred to as the sharing economy. In this essay, we provide an overview of current research on the economic efficiency and equity characteristics of ridesharing platforms, and provide a research agenda that includes an examination of the natural evolution toward driverless cars. We have three main findings: first, relatively little is known about either the equity and efficiency properties of ridesharing platforms, but this is likely to change as companies and researchers focus on these issues. Second, we may be able to learn something about the likely diffusion and benefits of these technologies from experience with other policies and technologies. Third, while we believe these platforms will do substantially more good than harm, the measurement, distribution, and size of the gains from these technologies requires further research. * Robert Hahn is professor and director of economics at the Smith School at the University of Oxford, a non-resident senior fellow at Brookings, and a senior fellow at the Georgetown Center for Business and Public Policy. Robert Metcalfe is Postdoctoral Research Scholar in Economics at the University of Chicago. We would like to thank Ted Gayer, Jonathan Hall, Scott Kominers, Jonathan Meer, Alex Teytelboym, Scott Wallsten, and Cliff Winston for helpful comments and Julia Schmitz, Brian Campbell and Samantha van Urk for excellent research assistance. The usual caveat applies. The Ridesharing Revolution: Economic Survey and Synthesis Robert Hahn and Robert Metcalfe
Host and Symbionts in Pocillopora damicornis Larvae Display Different Transcriptomic Responses to Ocean Acidification and Warming

As global ocean change progresses, reef-building corals and their early life history stages will rely on physiological plasticity to tolerate new environmental conditions. Larvae from brooding coral species contain algal symbionts upon release, which assist with the energy requirements of dispersal and metamorphosis. Global ocean change threatens the success of larval dispersal and settlement by challenging the performance of the larvae and of the symbiosis. In this study, larvae of the reef-building coral Pocillopora damicornis were exposed to elevated pCO2 and temperature to examine the performance of the coral and its symbionts in situ and better understand the mechanisms of physiological plasticity and stress tolerance in response to multiple stressors. We generated a de novo holobiont transcriptome containing coral host and algal symbiont transcripts and bioinformatically filtered the assembly into host and symbiont components for downstream analyses. Seventeen coral genes were differentially expressed in response to the combined effects of pCO2 and temperature. In the symbiont, 89 genes were differentially expressed in response to pCO2. Our results indicate that many of the whole-organism (holobiont) responses previously observed for P. damicornis larvae in scenarios of ocean acidification and warming may reflect the physiological capacity of larvae to cope with the environmental changes without expressing additional protective mechanisms. At the holobiont level, the results suggest that the responses of symbionts to future ocean conditions could play a large role in shaping success of coral larval stages.
A New Subspecies of Hawkmoth from Lanyu, Taiwan, with a Revised and Annotated Checklist of the Taiwanese Sphingidae (Lepidoptera)

Shen-Horn Yen, Ian J. Kitching and Chao-Shian Tzen (2003) A new subspecies of hawkmoth from Lanyu, Taiwan, with a revised and annotated checklist of the Taiwanese Sphingidae (Lepidoptera). Zoological Studies 42(2): 292-306. “Macroglossum lanyuana Chen” was first recorded from Lanyu (Orchid Island), Taiwan, in 1994, but this manuscript name has not been made available under the International Code of Zoological Nomenclature. We herein describe this taxon as Macroglossum ungues cheni ssp. nov. The relationships and biogeography of M. ungues Rothschild and Jordan, 1903 are discussed. The occurrence of M. ungues cheni on Lanyu corroborates geological evidence for the origin of the island. We also present an annotated checklist of the Taiwanese Sphingidae as an update to the Lepidoptera of Taiwan published in 1992. http://www.sinica. edu.tw/zool/zoolstud/42.2/292.pdf
Two controls of cell proliferation underlie cancer relapse

Much progress has been made in understanding the basis of cancer. Current therapies can effectively shrink tumors. But they frequently relapse, metastasize to other locations, and are lethal. Effective therapies are very much needed for preventing this relapse. Creation of a eukaryotic organism commences with one original stem cell, a fertilized egg, which multiplies and differentiates. Mutations of normal stem cells can produce cancer stem cells (CSC). These cells may resist chemotherapy, proliferate, and produce new tumors. Human chorionic gonadotrophin (hCG) is composed of two proteins (alpha and beta) that bind to the cell membrane and activate a number of intracellular pathways. hCG has been shown to activate the proliferation of cancer stem cells. Cyclin dependent regulation of the adult cells is created in normal differentiation and replaces the hCG regulation of stem cells. To selectively kill the cancer stem cells conventional cancer therapies could be followed with a therapy based on inactivating human chronic gonadotrophin (HCG). For example chemically modified prostaglandins like RU486 prevent binding of the unmodified steroid to hCG and inactivate hCG.
The relative value relevance of earnings and book value across industries

Many studies evaluate the impact of accounting information on price. This study, based on Collins, Maydew, and Weiss (1997), examines the disparity in the impact of book value and earnings on price over a twenty-year time period and for many industries. This paper extends Collins et al. (1997) by looking at changes in value relevance over a more recent time period. Also, this paper examines the differences in the value relevance of earnings and book values across industries. The results of this study suggest that the joint value relevance of earnings and book values has not decreased over the sample period. This study also demonstrates that the incremental value relevance of earnings (book value) has increased (stayed constant) for the sample period. Finally, this study demonstrates that there is no significant variation in the incremental value relevance of earnings and book values across industries.
Cold PSM, but not TRAIL, triggers autophagic cell death: A therapeutic advantage of PSM over TRAIL

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and cold plasma-stimulated medium (PSM) are promising novel anticancer tools due to their strong anticancer activities and high tumor-selectivity. The present study demonstrated that PSM and TRAIL may trigger autophagy in human malignant melanoma and osteosarcoma cells. Live-cell imaging revealed that even under nutritional and stress-free conditions, these cells possessed a substantial level of autophagosomes, which were localized in the cytoplasm separately from tubular mitochondria. In response to cytotoxic levels of PSM, the mitochondria became highly fragmented, and aggregated and colocalized with the autophagosomes. The cytotoxic effects of PSM were suppressed in response to various pharmacological autophagy inhibitors, including 3-methyladenine (3-MA) and bafilomycin A1, thus indicating the induction of autophagic cell death (ACD). Lethal levels of PSM also resulted in non-apoptotic, non-autophagic cell death in a reactive oxygen species-dependent manner under certain circumstances. Furthermore, TRAIL exhibited only a modest cytotoxicity toward these tumor cells, and did not induce ACD and mitochondrial aberration. The combined use of TRAIL and subtoxic concentrations of 3-MA resulted in decreased basal autophagy, increased mitochondrial aberration, colocalization with autophagosomes and apoptosis. These results indicated that PSM may induce ACD, whereas TRAIL may trigger cytoprotective autophagy that compromises apoptosis. To the best of our knowledge, the present study is the first to demonstrate that PSM can induce ACD in human cancer cells. These findings provide a rationale for the advantage of PSM over TRAIL in the destruction of apoptosis-resistant melanoma and osteosarcoma cells.
Flecainide-Induced Brugada Syndrome in a Patient With Skeletal Muscle Sodium Channelopathy: A Case Report With Critical Therapeutical Implications and Review of the Literature

Skeletal muscle sodium channelopathies are a group of neuromuscular disorders associated with mutations in the SCN4A gene. Because principal sodium channel isoforms expressed in the skeletal muscles and the heart are distinct one from the other, this condition usually spares cardiac functioning. Nonetheless, evidence on a possible link between skeletal muscle and cardiac sodium channelopathies has emerged in recent years. To date, eight patients bearing pathogenetic mutations in the SCN4A gene and manifesting cardiac electrophysiological alterations have been reported in literature. Among these patients, three presented a phenotype compatible with Brugada syndrome. We report the case of a 29-year-old patient affected by non-dystrophic myotonia associated with a p.G1306E mutation in the SCN4A gene, who presented symptoms of syncope and palpitation after the introduction of flecainide as an anti-myotonic agent. ECG and ajmaline challenge were consistent with the diagnosis of Brugada syndrome, leading to the implantation of a cardioverter defibrillator. No mutation in causative genes for Brugada syndrome was detected. Mexiletine treatment reduced myotonia without any cardiac adverse events. This case report highlights the clinical relevance of the recognition of cardiac electrophysiological alterations in skeletal muscle sodium channelopathies. The discovery of a possible pathogenetic linkage between skeletal muscle and cardiac sodium channelopathies may have significant implications in patients' management, also in light of the fact that class 1C anti-arrhythmics are potential triggers for life-threatening arrhythmias in patients with Brugada syndrome.
A 4 by 10 series 60 GHz microstrip array antenna fed by butler matrix for 5G applications

This paper presents a low-cost, beam-steerable 4 × 10 antenna array system operating at 60 GHz. The proposed antenna system is fed by a 4 × 10 Butler Matrix network designed using microstrip line (ML) structure. Chebyshev tapered microstrip antenna arrays with 10 series-fed elements are connected to four output ports of the feed network. Four steerable beams with maximum 16.5 dBi system gain and 1GHz bandwidth(BW) satisfy the requirements of millimeter wave propagation study and handset application for 5G communication.
Focused ultrasound brain stimulation to anesthetized rats induces long‐term changes in somatosensory evoked potentials

Low‐intensity transcranial focused ultrasound (FUS) has emerged as a noninvasive brain stimulation modality that can reach deep brain areas with high spatial specificity. Previous studies have identified transient effects of FUS on the brain excitability and accompanying physiological responses. Yet the presence of long‐lasting effects of FUS, which extend on the order of half an hour or more, has not been probed. We transcranially applied FUS to the somatosensory areas of the anesthetized rats for 10 min at a low duty cycle (5%) and intensity, far below the level that could alter the tissue temperature. Concurrently, we measured electroencephalographic somatosensory evoked potentials (SEP) induced by the unilateral electrical stimulation of the hind limb before and after the sonication. Compared with the control sham condition that did not involve sonication, differential SEP features were evident and persisted beyond 35 min after the administration of FUS. The presence of this nontransient neuromodulatory effect may provide early evidence that FUS‐mediated brain stimulation has the potential to induce neuroplasticity.
Activity recognition using accelerometer sensor and machine learning classifiers

Activity recognition is considered as an important task in many applications, particularly in healthcare services. Among these applications include medical diagnostic, monitoring of users' daily routine and detection of abnormal cases. This paper presents an approach for the activity recognition using an accelerometer sensor embedded in a smartphone. This approach uses a publicly available accelerometer dataset as the raw input signal. The features of the signal are selected based on the time and frequency domain. Then, Principal Component Analysis (PCA) is used to reduce the dimensionality of the features and extract the most significant ones that can classify human activities. A comparison process is performed between the original raw data and PCA-based features and additionally, time and frequency-domain features are also compared using several machine learning classifiers. The obtained results show that the PCA-based features obtain higher recognition rate while frequency-domain features have higher accuracy, with the rate of 96.11% and 92.10% respectively.
UMD at SemEval-2018 Task 10: Can Word Embeddings Capture Discriminative Attributes?

We describe the University of Maryland’s submission to SemEval-018 Task 10, “Capturing Discriminative Attributes”: given word triples (w1, w2, d), the goal is to determine whether d is a discriminating attribute belonging to w1 but not w2. Our study aims to determine whether word embeddings can address this challenging task. Our submission casts this problem as supervised binary classification using only word embedding features. Using a gaussian SVM model trained only on validation data results in an F-score of 60%. We also show that cosine similarity features are more effective, both in unsupervised systems (F-score of 65%) and supervised systems (F-score of 67%).
Virus survey in populations of two subspecies of bent-winged bats (Miniopterus orianae bassanii and oceanensis) in south-eastern Australia reveals a high prevalence of diverse herpesviruses

While bats are often viewed as carriers of infectious disease agents, little research has been conducted on the effects these potential pathogens may have on the bat populations themselves. The southern bent-winged bat (Miniopterus orianae bassanii) is a critically endangered subspecies endemic to south-eastern Australia. Population numbers of this bat have been declining for the past 50 years, but the reasons for this are unclear. As part of a larger study to determine if disease could be a contributing factor to this decline, 351 southern bent-winged bats from four locations were captured, and oral swabs were collected and tested for the presence of potentially pathogenic viruses. Results were compared with those obtained from 116 eastern bent-winged bats (Miniopterus orianae oceanensis) from three different locations. The eastern bent-winged bat is a related but more common and widespread subspecies whose geographical range overlaps partly with southern bent-winged bats. Herpesviruses were detected in bent-winged bats from all seven locations. At least six novel herpesviruses (five betaherpesviruses and one gammaherpesvirus) were identified. The prevalence of herpesvirus infection was higher in eastern bent-winged bats (44%, 51/116), compared to southern bent-winged bats (27%, 95/351), although this varied across the locations and sampling periods. Adenoviruses and a range of different RNA viruses (lyssaviruses, filoviruses, coronaviruses and henipaviruses) were also tested for but not detected. The detected herpesviruses did not appear to be associated with obvious ill health, and may thus not be playing a role in the population decline of the southern bent-winged bat. The detection of multiple novel herpesviruses at a high prevalence of infection is consistent with our understanding of bats as hosts to a rich diversity of viruses.