Miracle-dz/UniFAR-FTUs huggingface dataset:
IMMUNOLOGICAL CONTROL OF EPSTEIN‐BARR VIRUS INFECTION: POSSIBLE LESSONS FOR AIDS

Epstein-Barr (EB) virus' is spread by horizontal transmission and is ubiquitous in all human populations. ' Only human and certain subhuman primate B lymphocytes have been found to have receptors for the virus:-6 but although the receptor is associated with the C3d receptor,' it is distinct from Yet without virus receptors the malignant squamous epithelial cells of undifferentiated nasopharyngeal carcinoma (NPC) always carry copies of the viral genome,1o811 and the agent's mode of entry into the original cell giving rise to this monoclonal tumor'' remains obscure despite recent indications that human epithelial cells can be infected in v i t r ~ . ' ~ * ' ~ Even in B lymphocytes the replicative functions of the virus genome are not readily expressed in vitro. There is thus no fully permissive cell system, and the virus is difficult to work with in the laboratory. The usual techniques for ordinary "lytic" viruses cannot be employed, and EB virus must be obtained from those lymphoid cell lines in which some of the cells spontaneously enter the virus productive cycle ('producer' lines). Biological activity must be quantified on the basis of the transforming functions of the virus genome that confer on normal target B lymphocytes the ability to grow into continuous lines in culture. "
On the detectability of internal waves by an imaging lidar

The first results of a multisensor airborne survey conducted off the western Iberian Coast are presented (including visible, lidar, and infrared imagery) and reveal the presence of internal solitary waves (ISWs) propagating into the nearshore region. For the first time, two‐dimensional lidar imagery is shown to detect the presence of ISWs, and the results are interpreted in a more comprehensive framework provided by the remaining instrumentation. Sea surface roughness patterns, resulting from the ISWs, are found to be imaged in the lidar data, where specular reflection causes slicks to appear as areas of significantly reduced backscatter. Moreover, the lidar data reveal an unprecedented view into the ISW surface and subsurface structures. Possible interpretations are discussed based on the accumulation of surfactants and air bubble entrainment at the leading edge of the ISWs (where maximum convergence occurs).
Wideband low-noise optical beam deflection sensor with photothermal excitation for liquid-environment atomic force microscopy.

I developed a wideband low-noise optical beam deflection sensor with a photothermal cantilever excitation system for liquid-environment atomic force microscopy. The developed sensor has a 10 MHz bandwidth and 4.7 fm/sq.rt. Hz deflection noise density in water. The theoretically limited noise performance (i.e., the noise level limited only by the photodiode shot noise) has been achieved in liquid for the first time. Owing to the wide bandwidth and the replaceable focus lens design, the sensor is applicable to cantilevers with various dimensions. The deflection noise densities of less than 7.8 fm/sq.rt. Hz have been achieved in water for cantilevers with lengths from 35 to 125 microm. The ideal amplitude and phase versus frequency curves without distortion are obtained with the developed photothermal excitation system. The excitation system is applicable to relatively stiff cantilevers (>20 N/m) in liquid, making it possible to obtain true atomic-resolution images in liquid. True atomic-resolution imaging of mica in water is demonstrated using the developed deflection sensor and the photothermal excitation system.
Ethnic differences in the link between physical discipline and later adolescent externalizing behaviors.

BACKGROUND Parents' use of physical discipline has generated controversy related to concerns that its use is associated with adjustment problems such as aggression and delinquency in children. However, recent evidence suggests that there are ethnic differences in associations between physical discipline and children's adjustment. This study examined race as a moderator of the link between physical discipline and adolescent externalizing behavior problems, extending previous research beyond childhood into adolescence and considering physical discipline at multiple points in time. METHODS A representative community sample of 585 children was followed from pre-kindergarten (age 5) through grade 11 (age 16). Mothers reported on their use of physical discipline in the child's first five years of life and again during grades 6 (age 11) and 8 (age 13). Mothers and adolescents reported on a variety of externalizing behaviors in grade 11 including aggression, violence, and trouble at school and with the police. RESULTS A series of hierarchical linear regressions controlling for parents' marital status, socioeconomic status, and child temperament revealed significant interactions between physical discipline during the child's first five years of life and race in the prediction of 3 of the 7 adolescent externalizing outcomes assessed and significant interactions between physical discipline during grades 6 and 8 and race in the prediction of all 7 adolescent externalizing outcomes. Regression slopes showed that the experience of physical discipline at each time point was related to higher levels of subsequent externalizing behaviors for European American adolescents but lower levels of externalizing behaviors for African American adolescents. CONCLUSIONS There are race differences in long-term effects of physical discipline on externalizing behaviors problems. Different ecological niches may affect the manner in which parents use physical discipline, the meaning that children attach to the experience of physical discipline, and its effects on the adjustment of children and adolescents.
Digital simulation of voltage dip characteristics of wind turbine systems

Wind turbine electrical generation systems (WTGSs) with doubly-fed induction generators and variable speed capabilities have become popular because of its wide operation range and quality power output compared to the old fixed-speed squirrel-cage generators. The growing WTGS implantation have also increased the grid incidenses due to the wind parks and thus the study of the design of the control to improve the response to disturbances of these systems has become more important. The present work describes accurately a model for the wind-wheel, the transmition chain, the induction generator, the back to back converter (including the crow bar) and the electrical network. Also the simulation results of a voltage-dip response obtained from the implementation of the model are presented.
Mercury(II) Ion-Selective Polymeric Membrane Sensors for Analysis of Mercury in Hazardous Wastes

Two novel potentiometric sensors that are highly selective to Hg^2+ ions are described. These are based on the use of 5,5’- dithio-bis(2-nitrobenzoic acid) (DTNB) and tricyclazole (TCZ) as neutral carriers in plasticized poly(vinyl chloride) membranes. Fast Nernstian responses are obtained for Hg^2+ ions over the concentration ranges 7.0 × 10^−6 – 1.0 × 10^−2 and 7.7 × 10-^6 – 1.0 × 10^−2 mol 1^−1 at pH 1.8–3.3 with lower detection limits of 5.0 × 10^−6 and 5.6 × 10^−6 mol 1^−1 (~1 µg ml^−1) and calibration slopes of 30.0 and 29.7 mV decade^-1 with DTNB- and TCZ-based membrane sensors, respectively. Validation of the assay method reveals good performance characteristics, including long life span, good selectivity for Hg^2+ ions over a wide variety of other metal ions, long term response stability, and high reproducibility. Applications for direct determination of mercury in hazardous wastes including dental amalgam, mercury bulbs, and fluorescent lamps give results with good correlation with data obtained using cold vapor atomic absorption spectrometry.
Are sertraline, paroxetine and duloxetine the most effective antidepressants for use in depressed adults over 60 years?

ABSTRACT FROM: Thorlund K, Druyts E, Wu P, et al . Comparative efficacy and safety of selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors in older adults: a network meta-analysis. J Am Geriatr Soc 2015; 63 :1002–9. Although major depressive disorder (MDD) is less prevalent in older adults compared to in younger individuals, its somatic and psychological effects differ in these age groups.1 As such, it is important to evaluate the efficacy, safety and relative risk (RR) of antidepressants in patients with MDD, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs), as they are widely prescribed.2 The findings of this research are crucial to the field, as it will aid in determining treatment regimens for this population. The authors searched Medline, EMBASE, Cochrane Central Register of Controlled Trials, PsycINFO, Web of Science, clinicaltrials.gov and conference proceedings of major psychiatric conferences of the …
Indicators of hidden neuron functionality: the weight matrix versus neuron behaviour

Pruning of redundant or less important hidden neurons from the popular backpropagation trained neural networks is useful for a host of reasons, ranging from improvements of generalisation performance, to use as a precursor for rule extraction. For pruning it is necessary to identify hidden neurons with similar functionality. We have previously used a pruning process based on the behaviour of the hidden neurons in an image processing application to produce a quality driven compression by eliminating the least different hidden neurons. We consider the computationally cheaper alternative using only the trained weight matrix of the neural networks at each stage of the compression process. We conclude that the weight matrix is not sufficient for differentiating the functionality of the hidden neurons for this task, being essentially the functional equivalence problem which is computationally intractable.
A sequential antenna-hopping scheme for high mobility MIMO communications

In high mobility wireless communication scenarios, the most challenging issue is to cope with the extremely fast fading channel. Compared with its static counterpart, channel estimation in high mobility scenarios consumes excessive energy and spectrum to achieve similar performance. To address this issue, we exploit delay correlation with sequential antenna-hopping (AH) to convert the rapid fading channels to a virtual slow-fading channel. As a result, robust communication can be achieved with much less channel estimation overhead even under high mobility. Finally, two important performance metrics, namely, channel estimation mean square error (MSE) and transmission symbol error rate (SER), are re-examined for this virtual slow-fading channel. Numerical results verify the good performance of the proposed scheme and elucidate its effectiveness in high mobility communication scenarios.
A robust hand tracking for gesture-based interaction of wearable computers

Hand gesture-based interface is one of the most promising modes of natural and fluid human-computer interaction that substitutes for the mouse and keyboard in wearable computing systems. In wearable computing scenarios, hand positioning and tracking is particularly difficult due to complex background, lighting variation and image dithering caused by head movement. This paper proposes a robust hand tracking method for gesture-based interaction of a wearable computer with a visual helmet. The method is an extension of the basic CONDENSATION algorithm, which is able to track hand in dynamic and complex background. Furthermore, the algorithm can recognize the current hand gesture and automatically switch between multiple well-defined gesture templates in the tracking loop. The experimental results show that the proposed algorithm worked well in dynamic and complex background in real time.
Knockdown of nucleostemin can inhibit the proliferation of esophageal carcinoma cells in vitro through upregulating p21.

BACKGROUND/AIMS Esophageal squamous cell carcinoma is a common digestive tract cancer with poor prognosis. Nucleostemin is a nucleolar protein expressed in stem and cancer cells, involved in the regulation of cell proliferation. p21 plays an important role in negative regulation of the cell-cycle. We investigated the role of nucleostemin through regulating p21 expression in the occurrence and progression of human esophageal carcinoma. METHODOLOGY The expression of nucleostemin and p21 protein and of nucleostemin was knocked-down by means of RNA interference (RNAi) in Eca109 cells. Then, mRNA and protein expressions of nucleostemin and p21 were determined by reverse transcriptase polymerase chain reaction and Western blotting, respectively. In addition, the effect of nucleostemin RNAi on cell proliferation and cell cycle distribution of Eca109 cells were observed. RESULTS Nucleostemin was high expressed, but p21 was low expressed in esophageal carcinoma tissues while increased level of nucleostemin protein was associated with reduced p21. inhibition of nucleostemin resulted in an increased expression of p21 and inhibition of cell proliferation, cause G1/G0 phase cells increased and S-phase cells reduced greatly in Eca109 cells. CONCLUSION Silence of nucleostemin inhibit cell proliferation through up-regulating p21 expression and nucleostemin may be involved in the pathogenesis of esophageal squamous cell carcinoma.
Radiographic examination of the facial, nasal and paranasal sinus regions of the horse: I. Indications and procedures in 235 cases.

The radiographic procedures used for examination of the facial area and paranasal sinuses of 235 horses are reported. Clinical indications for these examinations and the diagnoses made are reviewed. Unilateral nasal discharge was the commonest reason for radiography, accounting for about one third of cases, most of which had radiological signs of paranasal sinus disease recognisable on erect lateral films. Oblique projections were required to obtain further information about the maxillary dental arcades and ventro-dorsal views demonstrated sinus expansion and extension of disease into the nasal cavity. In 24 horses with bilateral nasal discharge, the origin was usually shown to be in the lower respiratory tract and radiographic abnormalities were found in only 20 per cent of cases. Facial swelling was a feature of 25 per cent of cases; the commonest causes were premolar periapical disease, best shown on oblique views with the patient recumbent, and suture periostitis, easily demonstrated on erect lateral films. Other causes of facial swelling, which required multiple radiographic projections for evaluation, were sinus cysts and tumours and peripheral soft tissue masses. Epistaxis for which no cause could be found in the lower respiratory tract was the indication for radiography in a further 10 per cent of cases. In almost half of these a radiopaque shadow representing an ethmoid haematoma could be seen on an erect lateral film. A sinus cyst and a tumour were also recorded but most other causes of epistaxis failed to produce radiographic signs. (ABSTRACT TRUNCATED AT 250 WORDS)
Roll Controlfor aMicro Air Vehicle UsingActiveWing Morphing

TheUniversity of Florida hasbeenextremely active in thefield of MAV design andtesting. The teamled by Dr. PeterIfju is especially accomplishedin that they have won various aspects of the Micro Aerial Vehicle Competition, sponsoredby the International Society of Structural and Multidi sciplinary Optimization, each yearfrom 1999to 2002.His teamhasdesigned,built, andflown many unique designs ranging from 2 ft to 4 in wing spanthatareremotelypiloted usingvision feedbackto a ground station.
ATR Pathway Is the Primary Pathway for Activating G2/M Checkpoint Induction After Re-replication*

DNA replication is tightly controlled to ensure accurate chromosome duplication and segregation in each cell cycle. Inactivation of Geminin, an inhibitor of origin licensing, leads to re-replication in human tumor cells within the same cell cycle and triggers a G2/M checkpoint. We find that the primary pathway to signal that re-replication has been detected is the ATR kinase and the Rad9-Rad1-Hus1 (9-1-1) clamp complex together with Rad17-RFC clamp loader. ATM kinase and the Mre11-Rad50-Nbs1 complex do not appear to play significant roles in the checkpoint. Chk1 activation occurs at early stages, whereas Chk2 activation occurs much later. Overall we conclude that ATR/Chk1 pathway is activated at an early time point after the loss of Geminin and contributes to checkpoint arrest essential for the accumulation of re-replicated cells, whereas activation of the ATM/Chk2 pathway is a by-product of DNA re-replication at a later period.
Laser Microdissection–Mediated Isolation and In Vitro Transcriptional Amplification of Plant RNA

Laser microdissection of cells allows for isolation of specific cells of interest for downstream analyses including transcriptional profiling. Plant cells present unique challenges for laser microdissection due to their cellulosic cell walls and large vacuoles. Here we present protocols for plant tissue preparation, laser microdissection of select plant cells, and linear amplification of RNA from dissected cells. Linear amplification of RNA from dissected cells allows sufficient RNA for subsequent quantitative analysis by RT‐PCR, microarray, or RNA sequencing. © 2015 by John Wiley & Sons, Inc.
Event detection with vector similarity based on fourier transformation

Event detection through sensors data recording human activities is an aspect to learn human behaviors. In this paper, counted numbers from a sensor installed on a building entrance recording the number of people entering the building, will be processed to find the anomaly time interval when there are more people going through the entrance, which is viewed as event. An approach is adopted having two steps: first, the counted numbers over time is processed by Fourier Transformation and we get the parameter of a vector (ReX[k], ImX[k]) representing kth point in the data set; second, the vectors of (ReX[k], ImX[k]) are classified by KNN algorithm in two dimensions, categorizing the data in the same time interval in 70 days and the data in 48 intervals in one day. The results show that the proposed method works well.
Role of myoglobin in the antioxidant defense of the heart

Although the primary function of myoglobin (Mb) has been considered to be cellular O2 storage and supply, recent studies have shown that Mb in addition can act as NO oxidase. Here we report that Mb also significantly contributes to the attenuation of oxidative stress in cardiac muscle. In support of this hypothesis, we found that in isolated perfused hearts of Mb‐deficient (myo‒/‒) mice oxidative challenge by intracoronary infused H2O2 (1‐300 µM) or superoxide formed by 2,3‐dimethoxy‐1,4‐naphtoquinone (0.1‐30 µM), respectively, depressed cardiac contractility to a greater extent than in wild‐type (WT) hearts, e.g., up to [H2O2] = 10 µM there was a significant left ventricular developed pressure (LVDP) decrease in myo‒/‒ hearts only (90.4±4.2 vs. 98.1±0.7% of control, n=6, P<0.05). Likewise in an ischemia/reperfusion protocol, myo‒/‒ hearts showed a delayed recovery of postischemic function as compared with WT controls (e.g., LVDP was 35.6±7.5 vs. 22.4±5.3 mmHg, respectively, after 10 min of reperfusion, P<0.05, n=8), which correlated well with an enhanced release of reactive oxygen species in myo‒/‒ hearts as measured by online lucigenin‐enhanced chemiluminescence [e.g. 465±87 relative light units (RLU) in myo‒/‒ vs. 287±73 RLU in WT after 2.5 min of reperfusion, P<0.05, n=8]. 31P NMR spectroscopy revealed concomitantly a more pronounced phosphocreatine overshoot during reperfusion in the knockout but only minute alterations in ATP and pHi. Our data show that lack of Mb leads to increased vulnerability of cardiac function to oxidative challenge either pharmacologically induced or endogenously generated. We propose that Mb is a key element influencing redox pathways in cardiac muscle to functionally and metabolically protect the heart from oxidative damage.
Non-reciprocal beam behavior in two-dimensional photonic crystal slab

We simulate Gaussian beam propagation in two-dimensional photonic crystal slab (PCS). The found results show that character of beam propagation depends on the refractive index modulation on PCS boundaries. We observe a non-reciprocal beam behavior for PCS with different modulations on the boundaries. The non-reciprocity reaches its maximum at maximum of the refractive index modulation on the one boundary and minimum one on another boundary.
Leukocytosis in an Infant With Down Syndrome

A newborn female with Down syndrome initially presented to the neonatal intensive care unit with difficulty feeding, failure to thrive, and respiratory difficulty that required oxygen supplementation. She also had atrioventricular canal defect that was diagnosed prenatally. On physical examination, she had hepatosplenomegaly, as well as dysmorphic features typical of Down syndrome phenotype. Hemoglobin was 16.9, platelet count was 276 000, and white blood cells (WBC) count was 62 400 with the smear showing myelocytes, promyelocytes, and myeloblasts. WBC went as high as 80 000 with blast count as high as 44% and platelets as high as 771 000. Subsequent peripheral smear showed blasts, promyelocytes, metamyelocytes, and macrocytosis of red blood cells with normal platelets. The patient’s liver enzymes, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase were mildly elevated. Abdominal ultrasound revealed mild hepatosplenomegaly, minimal ascites, and gallbladder wall thickening. Further investigation with genetic and molecular biologic workup confirmed trisomy 21 as a somatic mutation and revealed GATA-1 mutation. The patient was negative for JAK2 V617 mutation. On flow cytometry, blasts were positive for CD34, CD117, HLADR, CD4, CD71, and CD9. Markers for megakaryocytic differentiation, CD41 and CD61, were partially expressed. Fluorescence in situ hybridization studies were inconclusive and attempts at obtaining additional genetic markers, specifically RUNX1, were unsuccessful.
The effect of mismatched filtering on the BER performance of /spl pi//4 shift DQPSK

The BER perfonnance of the /spl pi//4 shift DQPSK modulation with mismatched filtering is evaluated. It is shown that the loss due to the mismatched filtering in the /spl pi//4 shift DQPSK modulation of the APCO Project 25 standard can be kept within 0.3dB at BER of 10/sup -5/ with a deliberately designed FIR receive filter employed.
Stochastic Data Analysis and Modeling of a Telephone Call Center

In this paper, stochastic data models for the arrival process of a call center are investigated. Comprehensive analysis of real-life call center data revealed several problems with modeling arrival processes. The high uncertainty in the arrival counts during different time intervals and the strong correlation between arrivals counts in consecutive time periods show that using popular models are rather insufficient. A stochastic model is thus developed, for the arrival process, which successfully handles the above-mentioned difficulties. Arguments are provided for the suitability of the proposed model to characterize the arrival counts to model real-data obtained from large call center.