Miracle-dz/UniFAR-FTUs huggingface dataset:
Infants' Reactions to Visual Movement of the Environment

It has been demonstrated many times that the posture of infants is affected by movement of the visual environment. However, in previous studies, measurements taken with infants less than 10 to 12 months of age have always been recorded with the infants in a sitting position. An experiment is reported in which the postural reactions to a sinusoidal movement of the visual environment were recorded in infants 7 months of age and older standing with support. Fifty subjects divided into five groups (mean age 7.15 to 48.6 months) participated in the experiment. The groups differed in age and motor ability. Movement of the visual environment was achieved by means of a floorless room that could be moved sinusoidally in the anteroposterior axis. The subjects had to stand holding a horizontal bar fixed to a force-measurement platform. For each subject, measurements were made during four 60 s intervals: two with movement of the room and two with the room stationary. For all groups, reactions in the anteroposterior axis were stronger than in the lateral axis and this was true for both stimulus conditions. Comparison of the differences between the movement and stationary conditions in the anteroposterior axis, as a function of age, shows that the youngest infants seemed paradoxically to give stronger reactions when the room was stationary than when it was moving; the inverse was true for older infants and this difference increased with age. An analysis of the data with fast Fourier transforms reveals that the majority of subjects showed a pattern of postural reactions where the dominant (peak) frequency was identical to the peak frequency of room movement. The results of the present experiment lead to the conclusion that young infants react posturally to movements of their visual environment as soon as they are able to stand without help. Also, the best synchronization is found in infants that have just learned to stand without help. These results confirm that ‘visual proprioception’ assumes a leading role in the learning of a new stance.
Cultivation and Laboratory Maintenance of Chlamydia pneumoniae

Chlamydiae are Gram‐negative obligate intracellular parasites. Chlamydia pneumoniae is a human respiratory pathogen that causes pneumonia, bronchitis, sinusitis, and pharyngitis. C. pneumoniae has also been associated with cardiovascular disease. C. pneumoniae can only be grown in cell culture and is more difficult to isolate from specimens than Chlamydia trachomatis. Commonly used cell lines for isolation of C. trachomatis are not sensitive for C. pneumoniae. The most sensitive cell lines for isolation of C. pneumoniae are HL and HEp‐2. Centrifugation of the inoculum onto the monolayer and inclusion of cycloheximide in the medium enhance isolation. Inclusions are smaller than those of other chlamydiae and are visualized by staining with FITC‐conjugated genus‐ or C. pneumoniae–specific monoclonal antibodies. Slow expansion and use of a small inoculum are key to successful culture. Infectious organisms can be purified by use of Hypaque‐76 gradients to titers >1 × 108/ml. Curr. Protoc. Microbiol. 12:11B.1. 1‐11B.1. 23. © 2009 by John Wiley & Sons, Inc.
Occult nipple involvement in breast cancer: clinicopathologic findings in 316 consecutive mastectomy specimens.

PURPOSE Although breast-conserving surgery is a standard approach for patients with breast cancer, mastectomy often becomes necessary. Surgical options now include nipple-sparing mastectomy but its oncological safety is still controversial. This study evaluates frequency and patterns of occult nipple involvement in a large contemporary cohort of patients with the retroareolar margin as possible indicator of nipple involvement. PATIENTS AND METHODS Three hundred sixteen consecutive mastectomy specimens (232 therapeutic, 84 prophylactic) with grossly unremarkable nipples were evaluated by coronal sections through the entire nipple and subareolar tissue. Extent and location of nipple involvement by carcinoma was assessed with the tissue deep to the skin as potential retroareolar en-face resection margin. RESULTS Seventy-one percent of nipples from therapeutic mastectomies showed no pathologic abnormality, 21% had ductal carcinoma in situ (DCIS), invasive carcinoma (IC), or lymphovascular invasion (LVI), and 8% lobular neoplasia (lobular carcinoma in situ). Human epidermal growth factor receptor 2 amplification, tumor size, and tumor-nipple distance were associated with nipple involvement by multivariate analysis (P = .0047, .0126, and .0176); histologic grade of both DCIS (P = .002) and IC (P = .03), LVI (P = .03), and lymph node involvement (P = .02) by univariate analysis. Nipple involvement by IC or DCIS was identified in the retroareolar margin with a sensitivity of 0.8 and a negative predictive value of 0.96. None of the 84 prophylactic mastectomies showed nipple involvement by IC or DCIS. CONCLUSION Nipple-sparing mastectomy may be suitable for selected cases of breast carcinoma with low probability of nipple involvement by carcinoma and prophylactic procedures. A retroareolar en-face margin may be used to test for occult involvement in patients undergoing nipple-sparing mastectomy.
Presence of mouse mammary tumor virus specifically alters the body odor of mice

It has long been recognized that various genetic and metabolic human disorders alter body odor, which is not surprising because they may alter body chemistry. Thus, it has been suggested that some human diseases may be diagnosed by odor alone. In that regard, the mouse mammary tumor virus (MMTV) and its tumors of mice, which may have human counterparts, are of special interest because of the need for basic research possible only in inbred and genetically defined animals. Accordingly, we now show that the mouse MMTV, whether obtained environmentally or genetically transmitted, alters the body odor of mice in both males and females, and regardless of the presence or absence of tumors. These observations, together with the prospect of artificial human odor discrimination, may aid in the search for early human diagnostics.
Basic fibroblast growth factor inhibits cell proliferation in cultured avian inner ear sensory epithelia

Postembryonic production of inner ear hair cells occurs after insult in nonmammalian vertebrates. Recent studies suggest that the fibroblast family of growth factors may play a role in stimulating cell proliferation in mature inner ear sensory epithelium. Effects of acidic fibroblast growth factor (FGF‐1) and basic fibroblast growth factor (FGF‐2) were tested on progenitor cell division in cultured auditory and vestibular sensory epithelia taken from posthatch chickens. The effects of heparin, a glycosaminoglycan that often potentiates the effects of the FGFs, were also assessed. Tritiated‐thymidine autoradiographic techniques and 5‐bromo‐2`‐deoxyuridine (BrdU) immunocytochemistry were used to identify cells synthesizing DNA. The terminal deoxynucleotidyl transferase (TdT)‐mediated deoxyuridine triphosphate (dUTP)‐biotin nick‐end‐label (TUNEL) method was used to identify apoptotic cells. TUNEL and overall counts of sensory epithelial cell density were used to assess possible cytotoxic effects of the growth factors . FGF‐2 inhibited DNA synthesis in vestibular and auditory sensory epithelia and was not cytotoxic at the concentrations employed. FGF‐1 did not significantly alter sensory epithelial cell proliferation. Heparin by itself inhibited DNA synthesis in the vestibular sensory epithelia and failed to potentiate the effects of FGF‐1 or FGF‐2. Heparin was not cytotoxic at the concentrations employed. Results presented here suggest that FGF‐2 may be involved in inhibiting cell proliferation or stimulating precursor cell differentiation in avian inner ear sensory epithelia. J. Comp. Neurol. 424:307–326, 2000. © 2000 Wiley‐Liss, Inc.
Epidural Analgesia and Postoperative Outcome-Clinical Recommendations?

To the Editor: P öpping et al 1 have made an updated systematic review and meta-analysis of randomized controlled trials on the effect of epidural analgesia on postoperative mortality and morbidity. They conclude that epidural analgesia reduces postoperative mortality and that ‘‘the analysis adds to the evidence base of rational decision-making to ensure the most beneficial use of epidural analgesia in surgical patients. ’’ At first glance, this message is mostly welcome for one who has been involved in the pathophysiological perioperative benefits of epidural analgesia for 3 decades. However, their rather vague conclusion may leave clinicians in doubt, especially when looking at this updated analysis where about 75% of studies are from before 2004 and that 3 studies report mortality rates in the control group between 15% and 25%. Furthermore, the review has a complete lack of discussion of developments made within perioperative care principles during the last 10 years, not only in the included articles but also in the systematic review, and therefore may question the results and clinical relevance. Thus, in the rather few studies after 2004, the mortality was 12 versus 17 patients with about 600 patients in each group and from different types of surgical procedures and patients, thereby hindering sufficient interpretation and clinical recommendations. Over the last decade, it has repeatedly been documented that the concept of ‘‘fasttrack surgery’’ or ‘‘enhanced recovery programs’’ with implementation of procedurespecific evidence-based care principles (including epidural analgesia where appropriate) leads to enhanced recovery with reduced length of stay and morbidity. This may question the continuous reuse of old postoperative outcome studies for systematic reviews on single interventions from different surgical procedures. Instead, what is needed now are more procedure-specific studies on the effect of epidural analgesic regimens on postoperative recovery and morbidity when combined with a fully implemented evidence-based fast-track program. Importantly, such studies will be limited to a few procedures, because continuous epidural analgesia is now not evidence-based compared with other analgesic regimens in elective major orthopedic procedures, smaller to medium size gynecological and urological operations, laparoscopic colonic resection, or video-assisted thoracic surgery. Unfortunately, the review by Pöpping et al also fails to discuss these aspects, thereby leaving the clinicians in doubt about the relevance of their analysis. Nevertheless, continuous epidural postoperative analgesia may provide unique pathophysiological benefits (analgesia, ileus, pulmonary function, catabolism, etc) but needs to be addressed in a new way in appropriate and relevant specific surgical procedures to strengthen their conclusions and recommendations.
Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE‐MODEL randomized trial

Background: Oral anticoagulants, such as dabigatran etexilate, an oral, direct thrombin inhibitor, that do not require monitoring or dose adjustment offer potential for prophylaxis against venous thromboembolism (VTE) after total knee replacement surgery. Methods: In this randomized, double‐blind study, 2076 patients undergoing total knee replacement received dabigatran etexilate, 150 mg or 220 mg once‐daily, starting with a half‐dose 1–4 h after surgery, or subcutaneous enoxaparin 40 mg once‐daily, starting the evening before surgery, for 6–10 days. Patients were followed up for 3 months. The primary efficacy outcome was a composite of total VTE (venographic or symptomatic) and mortality during treatment, and the primary safety outcome was the incidence of bleeding events. Results: The primary efficacy outcome occurred in 37.7% (193 of 512) of the enoxaparin group vs. 36.4% (183 of 503) of the dabigatran etexilate 220‐mg group (absolute difference, −1.3%; 95% CI, −7.3 to 4.6) and 40.5% (213 of 526) of the 150‐mg group (2.8%; 95% CI,−3.1 to 8.7). Both doses were non‐inferior to enoxaparin on the basis of the prespecified non‐inferiority criterion. The incidence of major bleeding did not differ significantly between the three groups (1.3% vs. 1.5% and 1.3% respectively). No significant differences in the incidences of liver enzyme elevation and acute coronary events were observed during treatment or follow‐up. Conclusions: Dabigatran etexilate (220 mg or 150 mg) was at least as effective as enoxaparin and had a similar safety profile for prevention of VTE after total knee replacement surgery.
Exploring latent semantic information for textual emotion recognition in blog articles

Understanding people U+02BC s emotions through natural language is a challenging task for intelligent systems based on Internet of Things U+0028 IoT U+0029. The major difficulty is caused by the lack of basic knowledge in emotion expressions with respect to a variety of real world contexts. In this paper, we propose a Bayesian inference method to explore the latent semantic dimensions as contextual information in natural language and to learn the knowledge of emotion expressions based on these semantic dimensions. Our method synchronously infers the latent semantic dimensions as topics in words and predicts the emotion labels in both word-level and document-level texts. The Bayesian inference results enable us to visualize the connection between words and emotions with respect to different semantic dimensions. And by further incorporating a corpus-level hierarchy in the document emotion distribution assumption, we could balance the document emotion recognition results and achieve even better word and document emotion predictions. Our experiment of the wordlevel and the document-level emotion predictions, based on a well-developed Chinese emotion corpus Ren-CECps, renders both higher accuracy and better robustness in the word-level and the document-level emotion predictions compared to the state-of-theart emotion prediction algorithms.
Outpatient diabetes clinical decision support: current status and future directions

Outpatient clinical decision support systems have had an inconsistent impact on key aspects of diabetes care. A principal barrier to success has been low use rates in many settings. Here, we identify key aspects of clinical decision support system design, content and implementation that are related to sustained high use rates and positive impacts on glucose, blood pressure and lipid management. Current diabetes clinical decision support systems may be improved by prioritizing care recommendations, improving communication of treatment‐relevant information to patients, using such systems for care coordination and case management and integrating patient‐reported information and data from remote devices into clinical decision algorithms and interfaces.
A benchmark for quality indicators in multi-objective optimization.

Comparing the performance of different evolutive Multi-Objective algorithms is an open problem. With time, many performance measures have been proposed. Unfortunately, the evaluations of many of these performance measures disagree with the common sense of when a non-dominated set is better than another. In this work we present a benchmark that is helpful to check if a performance measure actually has a good behavior. Some of the most popular performance measures in literature are tested. The results are valuable for a better understanding of what performance measures are better.
To Stress or Not to Stress: A Question of Models

Stress research is a rapidly evolving field that encompasses numerous disciplines ranging from neuroscience to metabolism. With many new researchers migrating into the field, navigating the hows and whys of specific research questions can sometimes be enigmatic given the availability of so many models in the stress field. Additionally, as with every field, there are many seemingly minor experimental details that can have dramatic influences on data interpretation, although many of these are unknown to those not familiar with the field. The aim of this overview is to provide some suggestions and points to guide researchers moving into the stress field and highlight relevant methodological points that they should consider when choosing a model for stress and deciding how to structure a study. We briefly provide a primer on the basics of endpoint measurements in the stress field, factors to consider when choosing a model for acute stress, the difference between repeated and chronic stress, and importantly, influencing variables that modulate endpoints of analysis in stress work. © 2015 by John Wiley & Sons, Inc.
Flexion-Extension Cervical Spine MRI in Children With Skeletal Dysplasia: Is It Safe and Effective?

Background: Skeletal dysplasias may be associated with cervical spinal instability or stenosis. Cervical spine flexion-extension plain radiographs in children with skeletal dysplasia are difficult to interpret. The purpose of this study was to review the indications, efficacy, and safety of performing flexion-extension magnetic resonance imaging (MRI) under sedation/anesthesia in these children. Methods: Retrospective, Institutional Review Board–approved review of 31 children with skeletal dysplasia who underwent 38 cervical spine flexion-extension MRI studies under sedation/anesthesia. Indications included abnormal neurological examination, suspected instability, stenosis, or inconclusive findings on flexion-extension radiographs. Studies were performed by the radiology technologist as directed by the radiologist with an anesthesiologist present. MRI was evaluated for odontoid hypoplasia, os odontoideum, cerebrospinal fluid effacement, cord compression, spinal cord changes, cervical canal narrowing in the neutral, flexion, and extension positions. Neurological examinations were recorded before and after MRI to assess safety. Results: The average age at MRI was 3 years, 2 months. In 6 patients whose plain radiographs showed C1-C2 or subaxial instability, flexion-extension MRI showed no cord compression. Nine patients with inconclusive plain radiographs had abnormal MRI findings. An os odontoideum not seen on plain radiographs was diagnosed in 3 patients on flexion-extension MRI. On the basis of the MRI findings, 14 patients underwent surgery, 9/14 had increased cord compression in flexion or extension compared with neutral, and observation was continued in 17 others. Patients who underwent surgery had significant cord compression on MRI. There were no significant changes in the neurological examinations after MRI. Conclusions: Cervical spine flexion-extension MRI under sedation/anesthesia in children with skeletal dysplasia is safe under adequate supervision and is necessary to guide accurate medical and surgical decision making. Flexion-extension MRI is useful for identifying dynamic changes in canal diameter resulting in cord compression not seen on plain radiographs, and it is also useful for identifying patients with suspected plain film instability who may not have stenosis or cord compression on MRI. Study Design: Level IV—retrospective case series.
Sarcoidosis in an Italian province. Prevalence and environmental risk factors

Background and aim Sarcoidosis is a systemic granulomatous inflammatory disease whose causes are still unknown and for which epidemiological data are often discordant. The aim of our study is to investigate prevalence and spatial distribution of cases, and identify environmental exposures associated with sarcoidosis in an Italian province. Methods After georeferentiation of cases, the area under study was subdivided with respect to Municipality and Health Districts and to the altitude in order to identify zonal differences in prevalence. The bioaccumulation levels of 12 metals in lichen tissues were analyzed, in order to determine sources of air pollution. Finally, the analysis of the correlation between metals and between pickup stations was performed. Results 223 patients were identified (58.3% female and 41.7% male of total) and the mean age was 50.6±15.4 years (53.5±15.5 years for the females and 46.5±14.4 for the males). The mean prevalence was 49 per 100.000 individuals. However, we observed very heterogeneous prevalence in the area under study. The correlations among metals revealed different deposition patterns in lowland area respect to hilly and mountain areas. Conclusions The study highlights a high prevalence of sarcoidosis cases, characterized by a very inhomogeneous and patchy distribution with phenomena of local aggregation. Moreover, the bioaccumulation analysis was an effective method to identify the mineral particles that mostly contribute to air pollution in the different areas, but it was not sufficient to establish a clear correlation between the onset of sarcoidosis and environmental risk factors.
Context-sensitive cognitive-behavioural supports for young children with TBI: A replication study

Objective: To replicate an investigation of the effects of a multi-component cognitive-behavioural intervention on the challenging behaviour of two young children with growing behavioural concerns after TBI. Experimental design: Single-subject reversal designs used to document the effects of the combined behavioural, cognitive and executive function intervention on the following dependent variables: frequency and intensity of aggressive behaviours, amount of work accomplished. Participants: Two young children with escalating behaviour problems after TBI. Intervention: Integrated components of positive behaviour supports, cognitive supports (e.g. graphic organizers) and an executive function routine (goal-plan-do-review). Results: Reduced frequency and intensity of challenging behaviours; increased quantity of work completed. Conclusions: Positive replication of previous single-subject experiments demonstrating the potential for successfully treating behaviour disorders in young children with TBI using a support-oriented intervention that combines behavioural, cognitive and executive function components.
Effect of Low Versus High-Heeled Footwear on Spinopelvic Alignment at Different Phases of Menstrual Cycle in Young Adult Women: A Biopsychosocial Perspective

High-heeled shoes adversely affect spinal curvature, increase the risk of low back pain, and disturb the normal gait pattern. The purpose of this study was to examine, from a biopsychosocial point of view, the combined effect of wearing two different heel heights and of hormonal oscillation throughout different phases of the menstrual cycle on spinopelvic alignment. Notably, 70 females with an average age of 20.42 ± 1.51 years participated in this study, wearing each female two different heel heights as follows: low (2.5 cm) and high (7 cm). Spinopelvic alignment was evaluated by rasterstereography formetric 3D analysis during early follicular, ovulatory, and mid-luteal phases of the menstrual cycle. Statistical analysis showed that there was no significant difference (p > 0.05) on spinopelvic alignment [kyphotic angle (KA), trunk inclination (TI), and pelvic inclination] between wearing low- or high-heeled shoes during early follicular, ovulatory, and mid-luteal phases of the menstrual cycle. Considering that high-heeled shoes are traditionally associated with femininity, body image, beauty, and charm, this research has important biopsychosocial implications that should be explored in detail in future studies.