Miracle-dz/UniFAR-FTUs huggingface dataset:
The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal

Objective: Non-radiographic axial spondyloarthritis (SpA) is characterised by a lack of definitive radiographic sacroiliitis and is considered an early stage of ankylosing spondylitis. The objective of this study was to develop candidate classification criteria for axial SpA that include patients with but also without radiographic sacroiliitis. Methods: Seventy-one patients with possible axial SpA, most of whom were lacking definite radiographic sacroiliitis, were reviewed as “paper patients” by 20 experts from the Assessment of SpondyloArthritis international Society (ASAS). Unequivocally classifiable patients were identified based on the aggregate expert opinion in conjunction with the expert-reported level of certainty of their judgement. Draft criteria for axial SpA were formulated and tested using classifiable patients. Results: Active sacroiliitis on magnetic resonance imaging (MRI) (odds ratio 45, 95% CI 5.3 to 383; p<0.001) was strongly associated with the classification of axial SpA. The knowledge of MRI findings led to a change in the classification of 21.1% of patients. According to the first set of candidate criteria (sensitivity 97.1%; specificity 94.7%) a patient with chronic back pain is classified as axial SpA in the presence of sacroiliitis by MRI or x rays in conjunction with one SpA feature or, if sacroilitiis is absent, in the presence of at least three SpA features. In a second set of candidate criteria, inflammatory back pain is obligatory in the clinical arm (sensitivity 86.1%; specificity 94.7%). Conclusion: The ASAS group has developed candidate criteria for the classification of axial SpA that include patients without radiographic sacroiliitis. The candidate criteria need to be validated in an independent international study.
Hemangiopericytoma of the breast: mammographic and sonographic findings.

Hemangiopericytoma is a rare vascular tumor that can occur, anywhere in the body [1]. Involvement of the breast, however, is extremely unusual. The few reported cases of primary hemangiopericytoma in the breast mainly focus on the cytologic, histologic, and immunochemical features of the tumor [2-6]. To our knowledge, this is the first report in a radiologic publication to describe the mammographic and sonographic findings in primary hemangiopericytoma
Bcl-2 Prevents Bax Oligomerization in the Mitochondrial Outer Membrane*

ATP depletion results in Bax translocation from cytosol to mitochondria and release of cytochrome c from mitochondria into cytosol in cultured kidney cells. Overexpression of Bcl-2 prevents cytochrome c release, without ameliorating ATP depletion or Bax translocation, with little or no association between Bcl-2 and Bax as demonstrated by immunoprecipitation (Saikumar, P., Dong, Z., Patel, Y., Hall, K., Hopfer, U., Weinberg, J. M., and Venkatachalam, M. A. (1998) Oncogene 17, 3401–3415). Now we show that translocated Bax forms homo-oligomeric structures, stabilized as chemical adducts by bifunctional cross-linkers in ATP-depleted wild type cells, but remains monomeric in Bcl-2-overexpressing cells. The protective effects of Bcl-2 did not require Bcl-2/Bax association, at least to a degree of proximity or affinity that was stable to conditions of immunoprecipitation or adduct formation by eight cross-linkers of diverse spacer lengths and chemical reactivities. On the other hand, nonionic detergents readily induced homodimers and heterodimers of Bax and Bcl-2. Moreover, associations between translocated Bax and the voltage-dependent anion channel protein or the adenine nucleotide translocator protein could not be demonstrated by immunoprecipitation of Bax, or by using bifunctional cross-linkers. Our data suggest that the in vivo actions of Bax are at least in part dependent on the formation of homo-oligomers without requiring associations with other molecules and that Bcl-2 cytoprotection involves mechanisms that prevent Bax oligomerization.
Genetic diversity among maize (Zea mays L.) landraces assessed by RAPD markers

The genetic relationships among 81 maize accessions consisting 79 landraces and two improved varieties, maintained by farmers in southern Brazil were investigated using Random Amplified Polymorphic DNA (RAPD). Thirty-two highly informative primers amplified 255 markers of which 184 (72.2%) were polymorphics. Based on the RAPD markers, a dendrogram was constructed using the UPGMA method. The range of genetic similarity was from 0.78 to 0.91. The molecular data grouped the accessions into two main clusters, which were correlated according to kernel colors. Small clusters were seen associated to characteristics, such as kernel morphology. The analysis of the molecular data revealed that maize management adopted by small-scale farmers has contributed to the maintenance of genetic variability and since field isolation is a regular practice, variety identities have been preserved. These results will be useful to establish and maintain a germplasm collection of landrace maize and may guide us in designing strategies that maximize the utility of maize genetic resources.
An Overview of the Consequences of Distal Coronary Microembolization on Left Ventricular Function, Perfusion and Viability

Annually, an estimated 1,285,000 in-patient angioplasty procedures, 1,471,000 inpatient diagnostic cardiac catheteri-zations and 68,000 inpatient defibrillator implantations are performed. The direct and indirect cost of cardiovascular diseases for 2007 is approximately $431.8 billion. The occurrence of plaque rupture with subsequent microemboli of atherosclerotic and thrombolytic debris into small coronary vessels has been confirmed. Microinfarction results from microemboli that are shed following coronary interventions. The aims of this review are to: 1) detect heterogeneous microinfarction using viability imaging, 2) characterize the consequences of distal coronary microembolization on left ventricle function and perfusion and 3) illustrate the progress of non-invasive imaging modalities in assessing distal coronary microembolization.
The Convention on Biological Diversity's 2010 Target

Governments are often accused of responding only to short-term and parochial considerations. It is therefore remarkable that representatives of 190 countries recently committed themselves at the Convention on Biological Diversity to reducing biodiversity loss. This presents conservation biologists with perhaps their greatest challenge of the decade. The authors of this Policy Forum describe approaches to identifying more of the earth’s biological diversity; understanding how biological, geophysical, and geochemical processes interact; and presenting scientific knowledge in time to contribute to and achieve the 2010 target. Himalayan Journal of Sciences 3(5) 2005 p.43-45
Detection of the enteroaggregative Escherichia coli heat-stable enterotoxin 1 gene sequences in enterotoxigenic E. coli strains pathogenic for humans

The sequence of the enteroaggregative Escherichia coli enterotoxin 1 ( EAST1) gene was present in most (or all) strains of human-colonizing enterotoxigenic E. coli (ETEC) with colonization factor antigen II (CFA/II) or CFA/IV (CS6). The EAST1 gene was also strongly associated with PCF09+ ETEC or CFA/I+ ETEC elaborating heat-liable enterotoxin (and heat-stable enterotoxin I). In contrast, CFA/I+ ETEC elaborating heat-stable enterotoxin I, CFA/III+ ETEC, or CS17+ ETEC exhibited very weak or no associated. E. coli from healthy volunteers had no EAST1 gene sequence. A CFA/I+ ETEC strain (H10407) possessed multiple copies of the EAST1 gene on the CFA/I-encoding plasmid and chromosome. In one CFA/II+ ETEC strain, the EAST1 gene was present on the CFA/II-encoding plasmid. The EAST1 gene sequences of the CFA/I+ and CFA/II+ ETEC strains were identical to each other and 99.1% homologous to the reported gene sequence of enteroaggregative E. coli. The data indicate that the EAST1 gene is distributed among ETEC strains with a case of the presence of multiple copies in a single cell and that this distribution is associated with the adherence factor type.
Deep Triphone Embedding Improves Phoneme Recognition

In this paper, we present a novel Deep Triphone Embedding (DTE) representation derived from Deep Neural Network (DNN) to encapsulate the discriminative information present in the adjoining speech frames. DTEs are generated using a four hidden layer DNN with 3000 nodes in each hidden layer at the first-stage. This DNN is trained with the tied-triphone classification accuracy as an optimization criterion. Thereafter, we retain the activation vectors (3000) of the last hidden layer, for each speech MFCC frame, and perform dimension reduction to further obtain a 300 dimensional representation, which we termed as DTE. DTEs along with MFCC features are fed into a second-stage four hidden layer DNN, which is subsequently trained for the task of tied-triphone classification. Both DNNs are trained using tri-phone labels generated from a tied-state triphone HMM-GMM system, by performing a forced-alignment between the transcriptions and MFCC feature frames. We conduct the experiments on publicly available TED-LIUM speech corpus. The results show that the proposed DTE method provides an improvement of absolute 2.11% in phoneme recognition, when compared with a competitive hybrid tied-state triphone HMM-DNN system.
Voltage‐gated calcium currents in cultured embryonic Xenopus spinal neurones.

1. Voltage‐gated Ca2+ currents were studied in cultured embryonic Xenopus spinal neurones using whole‐cell gigaohm seal techniques. Cultures of neural plate cells were established from stage 15‐17 embryos (see Methods), and were studied for up to 80 h in vitro. During this period neural precursor cells morphologically differentiate and commence expression of multiple types of voltage‐ and ligand‐gated ion channels. 2. Embryonic Xenopus neurones studied during the first 20‐40 h in culture display Ca2+ currents that correspond to the low‐voltage‐activated (T‐type) and high‐voltage‐activated forms described in other neurones and excitable cells. These Ca2+ current types could be separated based on voltage dependencies and pharmacological sensitivities. 3. T‐type Ca2+ current was activated at voltages positive to ‐50 mV, and was selectively blocked by 200 microM‐Ni2+. Curves describing the voltage dependencies of activation and steady‐state inactivation overlapped in a region centred on ‐40 mV. A small sustained Ca2+ current could be recorded within this voltage region. 4. High‐voltage‐activated (HVA) Ca2+ currents were observed at voltages positive to ‐10 mV, and could be separated into relaxing and sustained components (denoted as HVA‐relaxing and HVA‐sustained). HVA‐relaxing current was selectively reduced by Met‐enkephalin (17.5 microM). Both components of HVA current were sensitive to verapamil (100 microM), were almost completely blocked by omega‐conotoxin (3 microM) and were insensitive to nifedipine (20 microM). 5. The data indicate that T‐type Ca2+ current is present in the membrane during the initial period of channel and receptor expression, process outgrowth, and synaptogenesis, and is the dominant influence on voltage‐gated Ca2+ influx during subthreshold voltage excursions. Further, at more positive voltages, T‐type Ca2+ current contributes to inward Ca2+ current during the first 5‐10 ms after depolarizing voltage steps, and thus to inward Ca2+ current during the rising phase of the long‐lasting Ca(2+)‐dependent embryonic action potential. HVA Ca2+ currents (particularly the relaxing component) influence the plateau phase.
Atypical manifestations of dengue

As the spread of dengue and dengue haemorrhagic fever is increasing, atypical manifestations are also on the rise, although they may be under reported because of lack of awareness. This review compiles descriptions of atypical manifestations of dengue, such as dengue encephalitis, dengue myocarditis, dengue hepatitis and dengue cholecystitis.
Impact of knowledge management on organizational performance: a case study of Grain Marketing Board (GMB)

This research sought to find the impact of knowledge management on organizational performance. The research used a case study approach in which a sample of 60 employees out of a population of 100 employees was used. The targeted population was stratified into departments from which a simple random sampling procedure was employed to come up with departmental representatives who were then summed to make the final 60 sample elements. Questionnaires and interviews were used in triangulation to collect data on the sample. An analysis of the collected data revealed that knowledge management had positively impacted on the performance of the organization through improvements in design time, costs reduction, employee flexibility and reduced employee frustration and confusion. However, the research also found that knowledge management can be negatively affected once a culture that embraces learning and sharing knowledge is minimum.
Organizational learning through corporate venture capital investments

Disclaimer This document contains a student thesis (bachelor's or master's), as authored by a student at Eindhoven University of Technology. Student theses are made available in the TU/e repository upon obtaining the required degree. The grade received is not published on the document as presented in the repository. The required complexity or quality of research of student theses may vary by program, and the required minimum study period may vary in duration.
Working Paper

We extend a framework of monopolistically competitive firms heterogeneous in productivity and with endogenous markups (as in Melitz and Ottaviano, 2008) to incorporate the presence of financial frictions. Before producing, firms need to obtain a loan necessary to cover part of production costs, for which they have to pledge collateral in the form of tangible assets. In addition to productivity, firms are also heterogeneous in their financial capability: some firms have access to collateral at lower costs. As a result, financial capability and collateral requirements enter together with productivity in the expression of the equilibrium firm-level markup. At the aggregate level, the model shows that tighter credit constraints in the form of higher collateral requirements mitigate the pro-competitive effect of trade. We validate our theoretical results capitalizing on a representative sample of manufacturing firms surveyed across a subset of European countries during the financial crisis. Guided by theory, we estimate for each firm financial capability, TFP and markups. We then employ those estimates to structurally retrieve from the model a firm-specific measure of collateral requirements (a proxy of credit constraint), and test our main propositions.
Workforce Analytics Approach: An Emerging Trend of Workforce Management

Workforce management is always a challenge for organizations of all sizes. Proper workforce planning to evaluate ability and utilization of workforce provides strategic intent of organizations using workforce analytics. Workforce analytics can measure the efficiency of workforce, provide correct information for decision making and improve the productivity of firms through identification of the loopholes of the workforce management processes. This paper discusses workforce analytics tools as the best of the breed practices of workforce management. The paper also discusses the scope and benefits of using Workforce analytics tools as an aid to workforce planning.
Strategies and Tools for Deployment of Web Services

— Web services are self-contained, self-describing, modular applications that can be published, located, and invoked across the web.A number of approaches have been proposed to deploy web services. This paper gives an overview of recent research effort of Web service deployment. Web services are being developed and deployed through various tools some of which are discussed in this paper. So, we present in this paper emerging technologies that we believe may play an important role in developing and deploying the next generation Web Services. The full deployment of Web services requires dealing with additional issues including Quality of Web Services (QoWS), Web service management, and security/privacy. As multiple Web services are expected to deliver similar functionalities, QoWS is considered as a key concept in distinguishing between competing Web services This paper describes an alternative approach towards service deployment capable of delivering on demand services in a workflow using cloud infrastructure capabilities
Cardiovascular health and physical activity in older adults: an integrative review of research methodology and results.

UNLABELLED PURPOSE OF THE PAPER: The purpose of this article is to review the literature on physical activity and its relationship to cardiovascular risk factors and mortality in older adults, in an effort to clarify the specific benefits and optimal level of physical activity for cardiovascular health in the older adult population. BACKGROUND/RATIONALE Despite physical activity being recognized as an important factor in the quality of life of older adults, there is a lack of clarity about the optimal level of physical activity that results in positive cardiovascular health benefits. DESIGN/METHODS An integrative review of the literature using the MEDLINE and CINAHL databases from 1990 through August 2000 was conducted identifying articles related to physical activity and cardiac risk factors, cardiovascular health, or mortality in the older adult. RESULTS/FINDINGS Forty-four research articles were reviewed. The intervention studies generally provided support for positive cardiovascular changes with exercise, but the results were inconsistent, sample sizes were small, and the outcomes, interventions, and measures of physical activity differed between studies. There was wide variation in the method of measurement of physical activity in the studies. Studies showed an increase in mortality in those who had a sedentary lifestyle compared to those who were more physically active. Results were mixed related to plasma lipids levels. Three studies showed a positive effect of physical activity on blood pressure (BP), while three studies showed no relationship. Each of the studies that evaluated the relationship between physical activity and pulse rate showed a decreased rate with increased physical activity. CONCLUSIONS The quantity and type of physical activity that should be recommended to bring about positive effects on cardiovascular health and mortality is unclear. There is support, however, that an active lifestyle decreases mortality. There is conflicting evidence to support positive effects of physical activity on cardiac risk factors. Further research is needed with larger sample sizes, better control of extraneous variables, and using measurements of physical activity that have undergone adequate psychometric testing.
Hydrogen in beryllium: solubility, transport and trapping

Rights: © 2009 American Physical Society (APS). This is the accepted version of the following article: Ganchenkova, M. G. & Borodin, V. A. & Nieminen, Risto M. 2009. Hydrogen in beryllium: Solubility, transport, and trapping. Physical Review B. Volume 79, Issue 13. 134101/1-11. ISSN 1550-235X (electronic). DOI: 10.1103/physrevb.79. 134101, which has been published in final form at http://journals.aps. org/prb/abstract/10.1103/PhysRevB.79. 134101.
SECURING WIRELESS SENSOR NETWORK USING GSTEB PROTOCOL

The Sleep/Wake up scheduling for Wireless Sensor Networks has become an essential part for its working. In this work, the Low Energy Adaptive Clustering Hierarchy (LEACH) which introduced the concept of clustering in sensor networks, EnergyEfficient Clustering routing algorithm based on Distance and Residual Energy for Wireless Sensor Networks (DECSA) which describes about scheduling based on distance and energy and the Energy efficient clustering algorithm for data aggregation (EECA) are going to be studied in detail. The LECSA (Load and Energy Consumption based Scheduling Algorithm) which gives a simplified method for scheduling using a node weighting parameter has been previously introduced perform Scheduling and Data Transmission in an efficient manner Every cluster head has to send the data collected from its child node directly to the sink, the cluster head should have a radio with high transmission range. So in this proposed work, the cluster head will find the nearest active node in the neighbor cluster and then it forwards its data to it. This can be achieved by General Self Organized Tree-Based Energy-Balance (GSTEB) using this protocols load balancing energy consumption has been introduced and detailed Keywords— Energy-balance, network lifetime, routing protocol, self-organized, wireless sensor network.
Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Science in Public Health in Biostatistics The

Interval censored survival data, where the exact event time is only known to lie in an observed time interval, is commonly encountered in practice. Such data analysis may be conducted under the setting where a fraction of patients can be considered as fully recovered and will not experience the event of interest in the future; while the other patients who did not recover totally will have the outcome of interest. We proposed a semiparametric estimation method for the proportional hazard mixture cure model, which is easy to implement and computationally efficient. A multiple imputation approach based on the asymptotic normal data augmentation (ANDA) is used to obtain parameter and variance estimates for both the cure probability and survival probability for uncured patients. A simulation study is performed to evaluate the proposed method and the results are compared with a fully parametric approach. The proposed method is applied to 2000-2010 Greater Georgia breast cancer dataset from the Surveillance, Epidemiology, and End Results (SEER) Program.
Optical waveguide materials with high thermal reliability and their applications for high-density optical interconnections

This paper describes newly-developed optical waveguide materials and their future applications in optoelectronic circuit boards. The materials achieved low optical loss and high thermal reliability, as well as good flexibility. We fabricated both flexible and rigid optoelectronic circuit board prototypes using these newly-developed materials, and successfully demonstrated light signal transmission faster than 10 Gbps/ch.