Miracle-dz/UniFAR-FTUs huggingface dataset:
Predictors of clozapine discontinuation in patients with schizophrenia

Clozapine has superior efficacy for treating patients with schizophrenia. Its discontinuation could have detrimental consequences. We attempted to identify the clinical parameters that could predict clozapine discontinuation in patients diagnosed as having schizophrenia by conducting a retrospective analysis of all of those who started on clozapine treatment during their hospitalization in our institution between 2002 and 2008 (n=100). Demographic and clinical parameters were analyzed and compared between the 58 patients who continued and the 42 who discontinued clozapine treatment during a follow-up period of 8.1 years. Twenty of the latter patients (47.6%) discontinued clozapine because of nonadherence and 11 (26.2%) because of side effects. Thirty-three of them (78.6%) stopped taking clozapine during the first year of treatment. The duration of clozapine use correlated significantly with the time to readmission (P<0.001). The decrease in number of suicide attempts was higher in those who continued clozapine treatment compared with those who discontinued it (P=0.02). Predictors for drug discontinuation were old age at clozapine initiation and comorbid substance abuse. These findings indicate that patients with schizophrenia with those risk factors need special incentives to be compliant during the first year of clozapine treatment to minimize the negative sequelae of clozapine discontinuation.
First-principles study of thermal transport in nitrogenated holey graphene

Nitrogenated holey graphene (NHG), a new two-dimensional graphene variant with a large fundamental direct band gap, has recently been successfully synthesized via a simple wet-chemical reaction. Motivated by its unique geometry and novel properties, we investigated the phonon transport properties of the material by combining first-principle calculations and the phonon Boltzmann transport equation. The lattice thermal conductivity of NHG at room temperature is predicted to be about 82.22 W mK−1, which is almost two orders of magnitude lower than that of graphene (about 3500 W mK−1). Deviating from the traditional understanding that thermal transport is usually largely contributed by the acoustic phonon modes for most suspended 2D materials, both out-of-plane flexural acoustic (ZA) and optical phonon modes make a more or less equal contribution, and their combination abnormally dominates the overall thermal transport in NHG. The major three-phonon process in NHG is further analyzed and the scattering between the acoustic and optical phonon modes like ZA / TA / LA + O ↔ O is the main phonon process channel. Meanwhile, the mean free path distribution of different phonon modes is calculated for the purpose of the thermal management of NHG-based devices. Our results elucidate the unusual thermal transport properties of NHG as compared with the representative case of graphene, and underpin its potential application for use by the thermal management community.
Sensor selection for target tracking in binary sensor networks using particle filter

In this paper, a new sensor selection scheme for target tracking in binary sensor networks using auxiliary particle filter is proposed that leads to computation complexity reduction. Binary sensor networks provide a set of binary signals based on presence or absence of target in detection region of sensors. Computation complexity of the particle filtering can be a major problem for its practical use in this application. We introduce a criterion for selecting neighbors for each sensor, and computation for target tracking is limited to one neighborhood of sensors, which is identified as the most important and effective neighborhood. Number of Floating-point Operations (FLOP) is considered as complexity measure in simulations, and accuracy of algorithms is investigated through Root Mean Square Error (RMSE). Simulation results show that our new method is less computationally complex in compare with an algorithm that is based on common auxiliary particle filter, and preserves the same accuracy.
Na+,K+-ATPase Functionally Interacts with the Plasma Membrane Na+,Ca2+ Exchanger to Prevent Ca2+ Overload and Neuronal Apoptosis in Excitotoxic Stress

Using a fluorescent viability assay, immunocytochemistry, patch-clamp recordings, and Ca2+ imaging analysis, we report that ouabain, a specific ligand of the Na+,K+-ATPase cardiac glycoside binding site, can prevent glutamate receptor agonist-induced apoptosis in cultured rat cortical neurons. In our model of excitotoxicity, a 240-min exposure to 30 μM N-methyl-d-aspartate (NMDA) or kainate caused apoptosis in ∼50% of neurons. These effects were accompanied by a significant decrease in the number of neurons that were immunopositive for the antiapoptotic peptide Bcl-2. Apoptotic injury was completely prevented when the agonists were applied together with 0.1 or 1 nM ouabain, resulting in a greater survival of neurons, and the percentage of neurons expressing Bcl-2 remained similar to those obtained without agonist treatments. In addition, subnanomolar concentrations of ouabain prevented the increase of spontaneous excitatory postsynaptic current's frequency and the intracellular Ca2+ overload induced by excitotoxic insults. Loading neurons with 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid or inhibition of the plasma membrane Na+,Ca2+-exchanger by 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) eliminated ouabain's effects on NMDA- or kainite-evoked enhancement of spontaneous synaptic activity. Our data suggest that during excitotoxic insults ouabain accelerates Ca2+ extrusion from neurons via the Na+,Ca2+ exchanger. Because intracellular Ca2+ accumulation caused by the activation of glutamate receptors and boosted synaptic activity represents a key factor in triggering neuronal apoptosis, up-regulation of Ca2+ extrusion abolishes its development. These antiapoptotic effects are independent of Na+,K+-ATPase ion transport function and are initiated by concentrations of ouabain that are within the range of an endogenous analog, suggesting a novel functional role for Na+,K+-ATPase in neuroprotection.
Detection and Significance of Blood Neutrophil CD 64 Expression as a Diagnostic Marker in Bacterial Meningitis in Children

Appropriate, rapid and reliable laboratory tests are essential for the diagnosis and therapy of acute bacterial meningitis especially in children. The purpose of this study was to evaluate the diagnostic value of flowcytometric detection of CD64 surface marker on blood neutrophils in diagnosis of acute bacterial meningitis. Our work included 132 (74 males and 58 females) patients with suspected meningitis, whose ages ranged from 2 months to 11 year. Patients were subjected to full clinical examination, complete blood count (CBC), cerebrospinal fluid (CSF) chemical and bacteriological analysis and detection of CD64 surface marker on blood neutrophils (CD64+ leucocytes). Based on the microbial culture results, patients were classified into bacterial meningitis group I (44) and non bacterial meningitis group II (88). The most prevalent isolates were Streptococcus pneumoniae (23) followed by H. influenzae (9) and N. meningitidis (6). Flowcytometry results indicated that the mean percentage of neutrophil CD64+ expression in bacterial meningitis (71.38±7.11) was significantly higher compared to culture negative meningitis (48.63±14.55) and controls (4.37 ±3.5). Flowcytometric assessment of neutrophil CD64 expression could serve as a reliable laboratory tool for detection of bacterial meningitis and may be a useful adjunct in differentiating bacterial and non bacterial meningitis
Impact of Helicobacter pylori Infection on the Humoral Immune Response to MUC1 Peptide in Patients with Chronic Gastric Diseases and Gastric Cancer

Many investigators have demonstrated alteration of gastric mucins in H. pylori infected individuals. The inflammatory environment induced by H. pylori leading to aberrant glycosylation of MUC1 and demasking of core peptide MUC1 epitope could enhance immune responses to MUC1. IgG and IgM immune response to MUC1 in patients with gastric cancer (n = 214) chronic gastroduodenal diseases (n = 160) and healthy blood donors (n = 91) was studied with ELISA using bovine serum albumin-MUC1 60-mer peptide as antigen. H. pylori serologic status was evaluated with ELISA and CagA status by immunoblotting. Gastric mucosa histology was scored according to the Sydney system. Compared to H. pylori seronegative individuals, higher levels of IgG antibody to MUC1 were found in H. pylori seropositive patients with benign gastric diseases (p < 0.01) and blood donors (p < 0.03). Higher MUC1 IgG antibody levels were associated with a higher degree of gastric corpus mucosa inflammation in patients with chronic gastroduodenal diseases (p < 0.0025). There was a positive correlation between the levels of anti-H. pylori IgG and MUC1 IgG antibody levels in blood donors (p = 0.03), and in patients with benign diseases (p < 0.0001). In patients with gastric cancer (n = 214) a significantly higher level of anti-MUC1 IgG than in blood donors was observed (p < 0.001) irrespective of H. pylori status or stage of cancer. MUC1 IgM antibody levels were not related to the H. pylori serology. IgG immune response to tumor-associated MUC1 is up regulated in H. pylori infected individuals. This increase is associated with a higher IgG immune response to H. pylori and with a higher degree of gastric mucosa inflammation. High levels of MUC1 IgG antibody irrespective of H. pylori serologic status characterized patients with gastric cancer. The findings suggest that, in some individuals, the H. pylori infection may stimulate immune response to tumor-associated MUC1 peptide antigen thus modulating tumor immunity.
A direct down-conversion receiver for coherent extraction of digital baseband signals using the injection locked oscillators

In today's digital wireless communications direct down-conversion receiver is becoming a favorite choice due to its overall simplicity and low cost. However, carrier recovery of the received digitally modulated RF signal for clear IQ signal extraction at high symbol rates is not so simple. Until now, phase-locked loop (PLL) and/or direct-digital synthesizers (DDS) or combination of both have been used for better performance but at the expense of high complexity or cost. In this paper for the first time we propose a direct down- conversion receiver that uses an injection-locked oscillator (ILO) for carrier recovery and frequency synthesizing. The results are shown for carrier recovery of a 2.1 GHz 20 Msps 8 PSK signal and coherent demodulation of a 2.78 GHz 160 Msps QPSK signal. The receiver presented is of low-cost and low-complexity and applicable to any kind of digitally modulated signals reception. It can be used in many wireless applications as WiMax, RFID and sensor networks.
The Parental Dental Concerns Scale (PDCS): its development and initial psychometric properties.

OBJECTIVES To assess the validity and reliability of a Parental Dental Concerns Scale (PDCS) to identify parents unable to access preventive dental care for their children. METHODS Two studies were conducted. In Study One, a purposive convenience sample of 399 Scottish parents answered questions on going to the dentist, family life and demographics. Parents were retested eight weeks later. In Study Two, 574 Scottish parents participating in a preventive oral health programme were posted the same questionnaire. Information on child dental attendance was gained from dental records. Data were analysed using exploratory (EFA) and confirmatory (CFA) factor analysis. Internal consistency and test-retest correlations provided reliability estimates. Validity was assessed with confirmatory factor analysis, correlations and independent t-tests. RESULTS EFA indicated that the PDCS had a four factor structure, supported by a subsequent CFA. The PDCS and its four subscales had good internal consistency, concurrent validity and test-retest reliability. Further work is required to confirm the scale's predictive validity in discriminating between children and parents who did and did not attend the dental practice. CONCLUSIONS The PDCS is a reliable scale, which demonstrates good construct validity. Further testing is required to confirm its predictive validity.
GMP-level adipose stem cells combined with computer-aided manufacturing to reconstruct mandibular ameloblastoma resection defects: Experience with three cases

Background: The current management of large mandibular resection defects involves harvesting of autogenous bone grafts and repeated bending of generic reconstruction plates. However, the major disadvantage of harvesting large autogenous bone grafts is donor site morbidity and the major drawback of repeated reconstruction plate bending is plate fracture and difficulty in reproducing complex facial contours. The aim of this study was to describe reconstruction of three mandibular ameloblastoma resection defects using tissue engineered constructs of beta-tricalcium phosphate (β-TCP) granules, recombinant human bone morphogenetic protein-2 (rhBMP-2), and Good Manufacturing Practice (GMP) level autologous adipose stem cells (ASCs) with progressively increasing usage of computer-aided manufacturing (CAM) technology. Materials and Methods: Patients’ three-dimensional (3D) images were used in three consecutive patients to plan and reverse-engineer patient-specific saw guides and reconstruction plates using computer-aided additive manufacturing. Adipose tissue was harvested from the anterior abdominal walls of three patients before resection. ASCs were expanded ex vivo over 3 weeks and seeded onto a β-TCP scaffold with rhBMP-2. Constructs were implanted into patient resection defects together with rapid prototyped reconstruction plates. Results: All three cases used one step in situ bone formation without the need for an ectopic bone formation step or vascularized flaps. In two of the three patients, dental implants were placed 10 and 14 months following reconstruction, allowing harvesting of bone cores from the regenerated mandibular defects. Histological examination and in vitro analysis of cell viability and cell surface markers were performed and prosthodontic rehabilitation was completed. Discussion: Constructs with ASCs, β-TCP scaffolds, and rhBMP-2 can be used to reconstruct a variety of large mandibular defects, together with rapid prototyped reconstruction hardware which supports placement of dental implants.
A Deep Learning Scheme for Motor Imagery Classification based on Restricted Boltzmann Machines

Motor imagery classification is an important topic in brain–computer interface (BCI) research that enables the recognition of a subject’s intension to, e.g., implement prosthesis control. The brain dynamics of motor imagery are usually measured by electroencephalography (EEG) as nonstationary time series of low signal-to-noise ratio. Although a variety of methods have been previously developed to learn EEG signal features, the deep learning idea has rarely been explored to generate new representation of EEG features and achieve further performance improvement for motor imagery classification. In this study, a novel deep learning scheme based on restricted Boltzmann machine (RBM) is proposed. Specifically, frequency domain representations of EEG signals obtained via fast Fourier transform (FFT) and wavelet package decomposition (WPD) are obtained to train three RBMs. These RBMs are then stacked up with an extra output layer to form a four-layer neural network, which is named the frequential deep belief network (FDBN). The output layer employs the softmax regression to accomplish the classification task. Also, the conjugate gradient method and backpropagation are used to fine tune the FDBN. Extensive and systematic experiments have been performed on public benchmark datasets, and the results show that the performance improvement of FDBN over other selected state-of-the-art methods is statistically significant. Also, several findings that may be of significant interest to the BCI community are presented in this article.
Andrographis paniculata Family : Acanthaceae Since ancient times

According to one of the ancient proverbs in India,” there is no plant on earth which has no medicinal property. ” More than 90% of the compounds used in modern medicine have their origin from plant sources. A large number of plants have been used by man from ancient times as medicine for curing various ailments. In recent times there is an upsurge of interest and focus on the importance of medicinal plants and traditional health systems in solving the health care problems of the world. This article gives an over view and a brief account of the important ethno-medicinal plants used in treating neoplastic diseases.
Using Particle Swarm Optimisation for Elastic Bunch Graph Matching to Recognise Faces

A new approach to face recognition, where elastic bunch graph matching technique optimised with particle swarm optimisation is proposed in this paper. It is a fully automatic algorithm and can be used for databases where only one image per person is available. A face is represented by a face graph. A face bunch graph is created as a generalised representation of faces of various individuals. The face graph similarity between the face bunch graph and the deformable graph that has to be fitted to the face in the image is maximised by particle swarm optimisation, to locate the landmarks and thereby to find the optimal graph to represent a face. Improved results were obtained by this method as apposed to elastic bunch graph matching without optimisation. Results were further improved by hybridising it with principal component analysis.
Reproducibility of hepatic fat fraction measurement by magnetic resonance imaging

To evaluate the reproducibility of magnetic resonance imaging (MRI)‐determined hepatic fat fraction (%) across imaging sites with different magnet types and field strength. Reproducibility among MRI platforms is unclear, even though evaluating hepatic fat fractions (FFs) using MRI‐based methods is accurate against MR spectroscopy.
Mandibular rotation and angular remodeling during childhood and adolescence

Using the structural method of superimposition, childhood and adolescent rates of mandibular rotation and remodeling are described. The results pertain to a longitudinal sample of French‐Canadian children, including 42 females with records at 6, 10, and 14 years of age and 39 males with records at 7, 11, and 15 years of age. There are no sex differences in rates of mandibular rotation and remodeling. Childhood rates of true rotation and angular remodeling are significantly greater than adolescent rates. Children whose first permanent molars had not erupted at the time of the first observation showed significantly greater rates of angular remodeling than children whose molars had already erupted. Over the eight year period, there were approximately 4.8 degrees of forward true rotation, between 5.2 and 6.4 degrees forward angular remodeling, and less than 1 degree of backward apparent rotation. During adolescence and the primary dentition stage, associations are strongest between true and apparent rotation. During the mixed dentition stage, true rotation is most closely correlated with angular remodeling. © 1992 Wiley‐Liss, Inc.
Cognitive biases and auditory verbal hallucinations in healthy and clinical individuals

Background Several cognitive biases are related to psychotic symptoms, including auditory verbal hallucinations (AVH). It remains unclear whether these biases differ in voice-hearers with and without a ‘need-for-care’. Method A total of 72 healthy controls, 72 healthy voice-hearers and 72 clinical voice-hearers were compared on the Cognitive Biases Questionnaire for psychosis (CBQp), which assesses ‘intentionalizing’, ‘jumping to conclusions’, ‘catastrophizing’, ‘dichotomous thinking’ and ‘emotional reasoning’ in vignettes characterized by two themes, ‘threatening events’ and ‘anomalous perceptions’. Results Healthy voice-hearers scored intermediately on total CBQp between the control and clinical groups, differing significantly from both. However, on four out of five biases the scores of the healthy voice-hearers were comparable with those of the healthy controls. The only exception was ‘emotional reasoning’, on which their scores were comparable with the clinical group. Healthy voice-hearers demonstrated fewer biases than the psychotic patients on the ‘threatening events’, but not the ‘anomalous perceptions’, vignettes. CBQp scores were related to both cognitive and emotional, but not physical, characteristics of voices. Conclusions Most cognitive biases prevalent in clinical voice-hearers, particularly with threatening events themes, are absent in healthy voice-hearers, apart from emotional reasoning which may be specifically related to the vulnerability to develop AVH. The association between biases and both beliefs about voices and distress/emotional valence is consistent with the close links between emotions and psychotic phenomena identified by cognitive models of psychosis. The absence of reasoning biases might prevent the formation of threatening appraisals about anomalous experiences, thereby reducing the likelihood of distress and ‘need for care’.
Low power consumption , low phase noise ring oscillator in 0 . 18 μm CMOS process

In this work, a new ring voltage controlled oscillator with a two cross coupled load PMOS transistors is proposed. The proposed method preserves the maximum frequency of the VCO unaffected which leads to improvement in phase noise and the power consumption of VCO oscillators. The proposed ring oscillator implemented in 0. 18μm CMOS shows the worse phase noise of -108 dBc/Hz at 10MHz offset, tuning range of 140.7%, while dissipating a maximum power consumption of 9 mW from 1.8 V supply. Keywords— Ring oscillators, VCO, tuning range, phase noise, cross coupled PMOS transistors.
Consumer trends and prefences in the demand for food

In this article we will analyse the major tastes and preferences of consumers in food consumption, as well as expected changes in these over time, and the impact that consumers have in establishing these trends. Five important consumer trends and purchase drivers are identified: food safety and health benefits, corporate social responsibility, production systems and innovations, sustainability and food origin. For each of these trends we will consider the actions that are being implemented by governments, NGOs and the private sector. In the final section, we will summarise the findings and discuss their implications for future food demand.
Using sustainability as a collaboration magnet to encourage multi-sector collaborations for health

The World Health Organization Commission on Social Determinants of Health (SDH) places great emphasis on the role of multi-sector collaboration in addressing SDH. Despite this emphasis on this need, there is surprisingly little evidence for this to advance health equity goals. One way to encourage more successful multi-sector collaborations is anchoring SDH discourse around ‘sustainability’, subordinating within it the ethical and empirical importance of ‘levelling up’. Sustainability, in contrast to health equity, has recently proved to be an effective collaboration magnet. The recent adoption of the Sustainable Development Goals (SDGs) provides an opportunity for novel ways of ideationally re-framing SDH discussions through the notion of sustainability. The 2030 Agenda for the SDGs calls for greater policy coherence across sectors to advance on the goals and targets. The expectation is that diverse sectors are more likely and willing to collaborate with each other around the SDGs, the core idea of which is ‘sustainability’.