Miracle-dz/UniFAR-FTUs huggingface dataset:
Theoretical Agile Process Framework for Mobile Application Development, Success Factors, and Evaluation

Mobile computing has now emerged as one of the main platform for advertising, e-commerce and integration to enterprise information system. Understanding this, A comprehensive model as an established software engineering methodology was proposed for mobile application, critical success factors and evaluation through theoretical agile process framework. It consist of four major parts namely: (A) Agile Methodology appropriate for mobile application, (B) Phases of Agile Software Process, (C) Critical Success Factors for Mobile Applications Development using Agile Methodology, and (D) Evaluation Criteria for Agile Mobile Application Development. For the development of the model, a Design Science Research (DSR) was adopted which is extensively used in information systems research to solve complex problems. DSR is not only appropriate to solve organizational problems in specific domains but also adequate to produce artifacts as it is the case of our model. It can be concluded that as Agile Methodology and approach has been becoming increasingly adoption in enterprise application development, the propose model illustrate the integration of the important components, attributes and factors for a successful mobile application development and deployment. Keywords—Agile, Mobile Application Development, CSF in Agile Methodology, SCRUM, Mobile Evaluation Criteria
Theory and Practice of Cryptography Solutions for Secure Information Systems

Information Systems (IS) are a nearly omnipresent aspect of the modern world, playing crucial roles in the fields of science and engineering, business and law, art and culture, politics and government, and many others. As such, identity theft and unauthorized access to these systems are serious concerns.Theory and Practice of Cryptography Solutions for Secure Information Systems explores current trends in IS security technologies, techniques, and concerns, primarily through the use of cryptographic tools to safeguard valuable information resources. This reference book serves the needs of professionals, academics, and students requiring dedicated information systems free from outside interference, as well as developers of secure IS applications. This book is part of the Advances in Information Security, Privacy, and Ethics series collection.
HWR for Indian Languages: A Comprehensive Survey

Few major Research works are going in the field of Handwriting Word Recognition (HWR) of Indian languages. This paper surveys the major works of offline/online handwritten word recognition. Techniques involved in word recognition are also discussed. Major works carried out in Bangla, Urdu, Tamil and Hindi are mentioned in this paper. Advancement towards HWR in other Indian languages are also discussed. Application of offline HWR is also discussed.
Concept Indexing of News Articles with Neural Systems

Preface For a long time self learning systems have caught my interest. A graduation in the area of Neural Networks would be only a logical step. As Alexandra Cristea put me on the idea of document searching with neural networks the following work is the result. There are two reasons for writing this article in English. First I want all members of the Information Systems group to be able to read and possibly comment on this article. Second it might be useful for future work (a student or an ilse employee) not to exclude people who are not familiar with the Dutch language. The first part of this report is a literature study, from chapter 7 on analyses on the input data are turned into design features, from chapter 14 on the realization of the code and the results are presented. In appendix A you will find an exercise to determine the data complexity growth with each new word occurrence (postings). In appendix B the design of a SOM neural network library is described. Appendix C is an exercise in creating a language detector. I wish to thank my colleagues at ilsemedia for their support and enthusiasm during the process of this report. Gratitude goes out to all authors who have published their papers on-line, this has made my task a lot easier. I wish to include the people at Citeseer for making it possible to find these articles. In all cases where the authors did not publish their work on-line my regards goes out to the university library. I wish to thank the following software developers who have provided (free) software for development , benchmarking or provision of my ideas: A final thank you I wish to address to all the people at the Eindhoven University. First of all the woman who talked me into this subject and provided me with (hopefully) enough wisdom for obtaining my master degree, dr. Alexandra Cristea. Of course this gratitude includes the rest of my graduation committee (Lora Aroyo, Rudolf Mak and Nils Rooijmans). Further I note Jaap vd Woude and Henny van Keulen who made it possible to start my graduation.
When vision is not an option: Development of haptic–auditory integration

To perform everyday tasks, such as crossing a road, we greatly rely on our sight. However, certain situations (e.g., an extremely dark environment) as well as visual impairments can either reduce the reliability of or completely remove this sensory information. In these cases, the use of other information is vital. Here we seek to examine the development of haptic and auditory integration. Three different groups of adults and 5- to 12-year-old children were asked to judge which of a standard sized and a variably sized ball was the largest. One group performed the task with auditory information only, haptic only or both. Auditory information about object size came from the loudness of a naturalistic sound played when observers knocked the ball against a touch-pad. A second group performed the same conditions, while wearing a thick glove to reduce the reliability of the haptic information. Finally, a third group performed the task with either congruent or incongruent information. Psychometric functions were fitted to responses in order to measure observers’ sensitivities to object size under these different conditions. Integration of haptic and auditory information predicts greater sensitivity in the bimodal condition than in either single-modality condition. Initial results show that young children do not integrate information from haptic and auditory modalities, with some children aged below 8 years performing worse in the bimodal condition than in the auditory-only condition. Older children and adults seem able to integrate auditory and haptic information, especially when the reliability of the haptic information is reduced.
Die Polypill – Ein praktikables Konzept?

Was ist neu? Vor- und Nachteile des Polypill-Konzepts Polypills können die Therapieadhärenz erhöhen, während insbesondere die Aspekte aus ärztlicher Sicht Therapiesicherheit und -flexibilität das Thema aktueller Diskussionen sind. Die Polypill in der Primärprävention Aufgrund der Nichtberücksichtigung individueller Risikofaktoren durch ihren „Massenmedikations“-Ansatz sollte die Polypill zur Primärprävention nur einem ausgewählten Hochrisikopatientengut vorbehalten bleiben. Sekundärprävention bei bereits optimal eingestellten Patienten sowie Primärprävention bei Hochrisikopatienten Zukünftige Studien müssen zeigen, dass die Anwendung von Polypills nicht nur einen positiven Einfluss auf Adhärenz und Surrogatparameter hat, sondern auch zu einer Reduktion kardiovaskulärer Ereignisse und letztendlich der Letalität führt.
Computational study of endothelial-mediated vascular responses at Y-bifurcation: when occlusion does not reduce the total flow

While vasoreactivity of an individual blood vessel is quite well studied, much less in known about stimulustriggered behavior of microcirculatory networks in situ . the available experimental data on topic suggest that the response pattern of the network, being the coordinated change of flow through the group of vessel, asa well as adjusment of their diameters, ofthen can be found inconsistent with what is expected from ”system of elastic tubes”. Physiologically, this is because of autoregulation of vascular tone by means of number of pathways, mediated by cells that form two main cellular layers - the endothelial cells and the vascular smooth muscle cells. Since it is still not easy to measure simulteneously bothe the flow/ diameter and the degree of activation of smooth muscle cells, the mathematical modeling study on topic is very suitable. In this work we present the results of modeling study performed on the set of 20 different variants of 14-vessels vascular tree. Our results show three distinctive stages of vascular response to the abrupt change of conditions (occlusion of one of vessels).
248-LB: Deficiency of APPL1 in Macrophages Triggers Adipose Tissue Inflammation and Insulin Resistance by Potentiating NLRP3 Inflammasome Activation

Adipose tissue inflammation participates in the pathogenesis of type 2 diabetes in obesity. While the activation of the multiprotein complex known as NLRP3 inflammasome and subsequent release of IL-1β contribute to the development of adipose tissue inflammation and insulin resistance, the mechanisms of its regulation remain unclear. Here we revealed that APPL1, an adaptor protein essential for adiponectin and insulin signaling, is upregulated in the stromal vascular fraction of visceral fat of db/db diabetic mice. Also, lack of APPL1 in bone marrow-derived macrophages specifically enhanced inflammatory response mediated by NLRP3 inflammasome. Mice with hematopoietic cells-specific APPL1 deficiency (APPL1-BMT-KO) were then generated using bone marrow transplantation approach and subjected to high-fat diet (HFD) feeding. After 36 weeks of HFD feeding, APPL1-BMT-KO mice exhibited increased insulin resistance and glucose intolerance, accompanied with elevated IL-1β in serum, liver and epididymal adipose tissue and impaired Akt phosphorylation in the subcutaneous adipose tissue and liver. In vitro experiments suggest that ablation of APPL1 in bone marrow-derived macrophages promotes IL-1β secretion by enhancing ROS generation, which is an important intracellular signal for NLRP3 inflammasome activation. Pharmacological inhibition of intracellular and mitochondrial ROS successfully abrogated the upregulation of IL-1β secretion in APPL1 deficient macrophages. In this study, we demonstrated the novel role of APPL1 in alleviating macrophage-mediated adipose tissue inflammation and insulin resistance. Lack of APPL1 in macrophages promotes ROS generation and NLRP3 inflammasome activation, which causes enhanced IL-1β secretion in adipose tissue and the development of insulin resistance. Disclosure K.K. L. Wu: None. A. Xu: None. K.K. Cheng: None. Funding Research Grants Council of Hong Kong (171018/15M)
Reflections on documenting the lexicon

The lexicon presents unique challenges in language documentation. This reflection reviews some of those challenges, focusing on two major areas, what I have learned over time about what is important to document and the creation of dictionaries. Throughout I stress the value of considering the lexicon broadly, and, in the situation that linguists are involved, of working closely with speakers and community members in all stages of decision making, from what to document to how to spell, to how to represent meanings. N. Scott Momaday writes of words as medicine, and this is important to keep in mind in lexical documentation—one is engaging with worldview. The responsibility then of documenting the lexicon is large, and the stakes are high, given how words give deep insight into ways of being.
Sensors fusion for head tracking using Particle filter in a context of falls detection

In the context of ageing societies, assessing risk factors and detecting falls for the elderly is becoming a crucial issue. In this paper, we propose an iterative head tracking method based on particle filtering using the fusion of low cost thermal and depth sensors for home environments whilst preserving privacy. The iteration process begins by segmenting the head in the depth image to calculate the depth coefficients and the thermal coefficients used for updating the particle weights. The method was tested on several sequences, with or without depth-thermal fusion: results show its robustness and accuracy , and also demonstrate that fusion improves tracking, namely when fast motion occurs (in case of a fall for instance) or when segmentation is erroneous.
Uncovering Social Spammers -Evaluation And Detection

For cyber criminals compromising social network accounts has turned into a beneficial strategy. Across the globe well known sites have millions of users and they suffer from a lot of security privacy and threats like profile cloning viral marketing rupture of security etc. By hijacking the control of a particular account, attackers or hackers can disperse their malicious information to an extensive client. It may affect the reputation of different organizations and leads to losses in financial markets. In this work, we show how we can utilize similar procedures to distinguish compromises of individual high profile accounts and they have one trademark that make this detection reliable. Behavioural analysis of each account has taken in order to get the normal behaviour of an account.
Impact of 5G Waveforms on Energy Harvesting Rectifier Performance

In this paper, an evaluation of impact of 5 MHz 5G FBMC waveforms on energy harvesting rectifier performance is presented. The 5 MHz 5G FBMC signals are used in Matlab. The simulated CCDFs of the rectifier for 5 MHz 5G signals at different input powers at 1.5 GHz are illustrated
Blueberry pomace, valorization of an industry by-product source of fibre with antioxidant capacity

Blueberries, apart from being rich in fibre, minerals and vitamins, are a relevant source of antioxidants, which have documented health promoting effects (Šarić et al., 2016). They have a particularly high content of polyphenols, anthocyanins, phenolic acids, flavanols, flavonols and tannins (Szajdek & Borowska, 2008). Ognat et al. (2011) and Šarić et al. (2016) observed that one of the richest sources of phenolic compounds is the blueberry pomace with an important antioxidant capacity.
Improving software maintenance using system-level reverse engineering

A FORTRAN reverse engineering software package is described which programmatically analyzes existing Fortran source code and generates complete structure charts and module specifications in a CASE environment. The user can also select options to create software trees and a variety of cross-reference tables. The use of these objects can increase programmer productivity by providing system-level details in a manner that can be easily understood. They also aid in the software maintenance process by providing the design baseline for future software modifications and added documentation of the software set. It is pointed out that integrating a system-level reverse engineering utility tool into a CASE environment is just one step toward improving programmer productivity and increasing success in the software maintenance process. <<ETX>>
Coast to coast: High genomic connectivity in North American scoters

Abstract Dispersal shapes demographic processes and therefore is fundamental to understanding biological, ecological, and evolutionary processes acting within populations. However, assessing population connectivity in scoters (Melanitta sp.) is challenging as these species have large spatial distributions that span remote landscapes, have varying nesting distributions (disjunct vs. continuous), exhibit unknown levels of dispersal, and vary in the timing of the formation of pair bonds (winter vs. fall/spring migration) that may influence the distribution of genetic diversity. Here, we used double‐digest restriction‐associated DNA sequence (ddRAD) and microsatellite genotype data to assess population structure within the three North American species of scoter (black scoter, M. americana; white‐winged scoter, M. deglandi; surf scoter, M. perspicillata), and between their European congeners (common scoter, M. nigra; velvet scoter, M. fusca). We uncovered no or weak genomic structure (ddRAD Φ ST < 0.019; microsatellite F ST < 0.004) within North America but high levels of structure among European congeners (ddRAD Φ ST > 0.155, microsatellite F ST > 0.086). The pattern of limited genomic structure within North America is shared with other sea duck species and is often attributed to male‐biased dispersal. Further, migratory tendencies (east vs. west) of female surf and white‐winged scoters in central Canada are known to vary across years, providing additional opportunities for intracontinental dispersal and a mechanism for the maintenance of genomic connectivity across North America. In contrast, the black scoter had relatively elevated levels of divergence between Alaska and Atlantic sites and a second genetic cluster found in Alaska at ddRAD loci was concordant with its disjunct breeding distribution suggestive of a dispersal barrier (behavioral or physical). Although scoter populations appear to be connected through a dispersal network, a small percentage (<4%) of ddRAD loci had elevated divergence which may be useful in linking areas (nesting, molting, staging, and wintering) throughout the annual cycle.
New mechanism-based inhibitors of aspartate transcarbamoylase for anticancer drug development

Aspartate transcarbamoylase (ATCase) is a key enzyme which regulates and catalyzes the second step of de novo pyrimidine synthesis in all organisms. E. coli ATCase is a prototypic enzyme regulated by both product feedback and substrate cooperativity, whereas human ATCase is a potential anticancer target. Through structural and biochemical analyses, we revealed that R167/130’s loop region in ATCase serves as a gatekeeper for the active site, playing a new and unappreciated role in feedback regulation. Based on virtual compound screening simultaneously targeting the new regulatory region and active site of human ATCase, two compounds were identified to exhibit strong inhibition of ATCase activity, proliferation of multiple cancer cell lines, and growth of xenograft tumors. Our work has not only revealed a previously unknown regulatory region of ATCase that helps explain feedback regulation, but also successfully guided the identification of new ATCase inhibitors for anticancer drug development using a dual-targeting strategy.
SENTIMENTS ANALYSIS IN ONE GO

Propose system tend to concentrate on modeling user-generated review and overall rating pairs and aim to spot linguistics aspects and aspect-level sentiments from review knowledge similarly on predict overall sentiments of reviews. we tend to propose a completely unique probabilistic supervised joint side and sentiment model (SJASM) to upset the issues in one go underneath a unified framework. SJASM represents every review document within the style of opinion pairs, and might at the same time model side terms and corresponding opinion words of the review for hidden side and sentiment detection. It conjointly leverages sentimental overall ratings, which regularly comes with on-line reviews, as superintendence knowledge, and might infer the linguistics aspects and aspect-level sentiments that aren't solely purposeful however conjointly prognosticative of overall sentiments of reviews. Moreover, we tend to conjointly develop economical illation methodology for parameter estimation of SJASM supported folded Gibbs sampling. We tend to judge SJASM extensively on real-world review knowledge, and experimental results demonstrate that the planned model outperforms seven well-established baseline strategies for sentiment analysis tasks. We build social network web site on that user post with attaching files, thereon file topic name match with product name then suggest to user on e-commerce web site.
Effects of Gentian Violet and Boric Acid on Growth of The Fungi: Aspergillus flavus, Penicillium chrysogenum and P. expansum

The maximum Percentage inhibition of growth of Aspergillus flavus (which can cause a wide spectrum of diseases ranging from allergic to a life-threatening invasive disease Aspergillosis). P. chrysogenum and P. expansum whose mycotoxins can cause significant health risks ranging from the infections of fruits, vegetables and milk products to immune compromised individuals), by an organic dye (Gentian Violet) were 78.8, 77.7 and 76.6% respectively. While that of inorganic boric acid of (2%) maximum concentrations inhibition were (44.4, 52.2 and 61.1 %) respectively. This results was attributed to the amphiphilic properties of this dye i.e. its high solubility in both aqueous (hyrophilic) and organic (lipophilic) phases and became effective at site in the body (the cell membrane) and it must also be able to reach that sites. ــــــــــــــــــــــــــــــــــــــــــــــــ تايرطف ومن ىلع كيروبلا ضماحو ةيجسفنبلا نشنجلا ةغبص ريثأت و Penicillium chrysogenum و Aspergillus flavus Penicillium expansum
Identification of novel targets for the treatment of type 2 diabetes

Introduction: With the worldwide prevalence of diabetes continuing to increase, and current treatments aimed at increasing insulin secretion often losing effectiveness over time, it is imperative to develop new therapeutic strategies that function through independent mechanisms to those already developed. Methods and aims: Isolated CD1 mouse islets, INS-1 β-cells and C2C12 skeletal muscle cells were cultured in control or glucolipotoxic environments as a model of type 2 diabetes. Using a combined approach of transcriptomics, PCR analysis, protein expression, fluorescent probes, in silico modelling, and cellular function assays, new therapeutic targets and treatments to augment insulin secretion in type 2 diabetes have been identified. Results: Carnosine and β-alanine supplementation was shown to inhibit reactive species generation and to increase stimulated insulin secretion. Importantly it was also able to reverse glucolipotoxicity-associated inhibition of insulin secretion typically seen in type 2 diabetes. However, due to rapid hydrolysis of carnosine by carnosinase enzymes in the body, these treatment strategies are likely to be of only modest benefit to patients. In silico derived compounds designed to inhibit carnosinase-2 activity had surprisingly little effect on reactive species scavenging or cellular function in β-cells however. Nevertheless, carnosinase inhibitors may still offer a III realistic treatment strategy in patients, as β-cells are limited by carnosine concentrations ~1,000 fold lower than those observed in tissues linked to insulin resistance, such as skeletal muscle. Illumina HiSeq gene expression analysis identified trace amine associated receptor (TAAR) expression as being significantly downregulated by glucolipotoxicity. Furthermore, TAARs were shown to regulate insulin secretion through adenylyl cyclase activation and cAMP mediated enhanced insulin secretion. Addition of physiological TAAR ligands was also shown to be able to amplify secretagogue-stimulated insulin release. Conclusion: This body of work will pave the way for future studies seeking to develop and further characterise carnosine and novel carnosine derived analogs as potential therapeutic agents to reverse glucolipotoxic cellular dysfunction. Modulation of heterotrimeric G-protein coupled receptor signalling through TAAR agonists may also represent a new therapeutic strategy to combat type 2 diabetes.
Word Sense Disambiguation

Word sense disambiguation (WSD) is the task of selecting the appropriate senses of a word in a given context. It is essence of communication in a natural language. It is motivated by its use in many crucial applications such as Information retrieval, Information extraction, Machine Translation, Partof-Speech tagging, etc. Various issues like scalability, ambiguity, diversity (of languages) and evaluation pose challenges to WSD solutions. The aim of this project is to develop a WSD technique which can handle all these issues with better accuracy and performance. This report presents our preliminary work towards solving the problem.