Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantitative Proteomics Analysis of Ischemia/Reperfusion Injury-Modulated Proteins in Cardiac Microvascular Endothelial Cells and the Protective Role of Tongxinluo

Background: The protection of endothelial cells (ECs) against reperfusion injury has received little attention. In this study, we used Tandem Mass Tag (TMT) labeling proteomics to investigate the modulated proteins in an in vitro model of cardiac microvascular endothelial cells (CMECs) subjected to ischemia/reperfusion (I/R) injury and their alteration by traditional Chinese medicine Tongxinluo (TXL). Methods: Human CMECs were subjected to 2 h of hypoxia followed by 2 h of reoxygenation with different concentrations of TXL Protein expression profiles of CMECs were determined using tandem mass spectrometry. We evaluated several proteins with altered expression in I/R injury and summarized some reported proteins related to I/R injury. Results: TXL dose-dependently decreased CMEC apoptosis, and the optimal concentration was 800 µg/mL. I/R significantly altered proteins in CMECs, and 30 different proteins were detected between a normal group and a hypoxia and serum deprivation group. In I/R injury, TXL treatment up-regulated 6 types of proteins including acyl-coenzyme A synthetase ACSM2B mitochondrial (ACSM2B), cyclin-dependent kinase inhibitor 1B (CDKN1B), heme oxygenase 1 (HMOX1), transcription factor SOX-17 (SOX17), sequestosome-1 isoform 1 (SQSTM1), and TBC1 domain family member 10B (TBC1D10B). Also, TXL down-regulated 5 proteins including angiopoietin-2 isoform c precursor (ANGPT2), cytochrome c oxidase assembly factor 5 (COA5), connective tissue growth factor precursor (CTGF), cathepsin L1 isoform 2 (CTSL), and eukaryotic elongation factor 2 kinase (LOC101930123). These types of proteins mainly had vital functions, including cell proliferation, stress response, and regulation of metabolic process. Conclusions: The study presented differential proteins upon I/R injury through a proteomic analysis. TXL modulated the expression of proteins in CMECs and has a protective role in response to I/R.
Toponyme in der Literatur: Ein kognitivistischer Ansatz

­frontiert wird? Beginnt man sich diesen Fragen zuzuwenden, fallt zunachst einmal auf, dass sich die literarische Onomastik bislang nur verhaltnismasig wenig mit Ortsnamen befasst hat: Literarische Onomastik ist vorwiegend literarische Anthroponomastik. Ein statistischer Vergleich, etwa in einer Zeitschrift fur literarische Onomastik, kann diese Behauptung leicht erharten. Da es im deutschen Sprachraum keine derartige Zeitschrift gibt, soll dafur die italie­ nische Zeitschrift il Nome nel testo herangezogen werden. Jeder Jahresband dieser Zeitschrift ist am Ende mit einem Verzeichnis der erwahnten Eigenna
From PID to Nonlinear State Error Feedback Controller

In this paper an improved nonlinear state error feedback controller (INLSEF) has been proposed for perfect reference tracking and minimum control energy. It consists of a nonlinear tracking differentiator together with nonlinear combinations of the error signal. The tracking differentiator generates a set of reference profile for the input signal, which is the signal itself in addition to its derivatives. On the other hand, the 12-parameters nonlinear combinations of the error signal make the INLSEF controller can handles with time-varying and system’s nonlinearity. Digital simulation studies have been conducted for the proposed controller and compared with several works from literature survey on two case studies, mass-spring-damper which is a very nonlinear system and nonlinear ball and beam systems. The parameters of the nonlinear combination of the error signal are tuned to satisfy the optimality condition by minimizing the OPI performance index defined in this work. From the simulations results one can conclude that the proposed INLSEF controller performance is better than that of its counterpart in terms of speed and control energy and minimum error. Also, the results showed that the proposed controller is effectively enhancing the stability and performance of the closed loop system.
Survival of Spoilage and Pathogenic Microorganisms on Cardboard and Plastic Packaging Materials

The aim of this work was to study the interaction of corrugated and plastic materials with pathogenic and spoiling microorganisms frequently associated to fresh produce. The effect of the two packaging materials on the survival during the storage of microorganisms belonging to the species Escherichia coli, Listeria monocytogenes, Salmonella enteritidis, Saccharomyces cerevisiae, Lactobacillus plantarum, Pseudomonas fluorescens, and Aspergillus flavus was studied through traditional plate counting and scanning electron microscopy (SEM). The results obtained showed that cardboard materials, if correctly stored, reduced the potential of packaging to cross-contaminate food due to a faster viability loss by spoilage and pathogenic microorganisms compared to the plastic ones. In fact, the cell loads of the pathogenic species considered decreased over time independently on the inoculation level and packaging material used. However, the superficial viability losses were significantly faster in cardboard compared to plastic materials. The same behavior was observed for the spoilage microorganisms considered. The SEM microphotographs indicate that the reduction of superficial contamination on cardboard surfaces was due to the entrapping of the microbial cells within the fibers and the pores of this material. In addition, SEM data showed that the entrapped cells were subjected to more or less rapid lyses, depending on the species, due to the absence of water and nutrients, with the exception of molds. The latter spoilers were able to proliferate inside the cardboard fibers only when the absorption of water was not prevented during the storage. In conclusion, the findings of this work showed the reduction of cross-contamination potential of corrugated compared to plastic packaging materials used in fruit and vegetable sector. However, the findings outlined the importance of hygiene and low humidity during cardboard storage to prevent the mold growth on packaging.
Adapting Multiple-Choice Item-writing Guidelines to an Industrial Context

This paper proposes a guideline for writing MCQ items for our domain which promotes the use of Multiple Alternative Choice (MAC) items. This guideline is derived from one of the guidelines from the Taxonomy of item-writing guidelines reviewed by Haladyna et al, 2002. The new guideline is tested by delivering two sets of MCQ test items to a representative sample of candidates from the domain. One set of items complies with the proposed guideline and the other set of items does not. Evaluation of the relative effectiveness of the items in the experiment is achieved using established methods of item response analysis. The experiment shows that the new guideline is more applicable to the featured domain than the original
Markov-Tree model of intrinsic transport in Hamiltonian systems.

A particle in a chaotic region of phase space can spend a long time near the boundary of a regular region since transport there is slow. This "stickiness" of regular regions is thought to be responsible for previous observations in numerical experiments of a long-time algebraic decay of the particle survivial probability, i.e., survival probability $\ensuremath{\sim}{t}^{\ensuremath{-}z}$ for large $t$. This paper presents a global model for transport in such systems and demonstrates the essential role of the infinite hierarchy of small islands interspersed in the chaotic region. Results for $z$ are discussed.
Making metals in East Africa and beyond: archaeometallurgy in Azania, 1966–2015

Over the course of the last 50 years, the field of archaeometallurgy has grown dramatically, becoming firmly established within the realm of archaeological science. The archaeology and ethnography of African metallurgy have made a major contribution to this field, providing valuable information on the impressive range of raw materials and techniques that past metal producers and metalworkers used, as well as providing important insights into the socio-cultural settings within which these technologies operated. This paper summarises the role that Azania has played in communicating some of this research, and charts the development of African archaeometallurgy through Azania’s pages.
Comparison of analgesic effect of interferential therapy and transcutaneous electrical nerve stimulation on pressure pain threshold on young healthy individuals

Objectives: The purpose of this study is to compare the analgesic effect of interferential therapy (IFT) and transcutaneous electrical nerve stimulation (TENS) on pain pressure threshold (PPT) in young healthy subjects. Materials and Methods: A comparative, crossover study involving 30 volunteers was conducted at Physiotherapy College. Inclusion criteria were healthy subjects, aged 18-25 years, taking no analgesic medication. Exclusion criteria were any painful musculoskeletal conditions, any contraindications to electrotherapy. IFT (Base-100 HZ, Sweep-0 HZ, 4PV90) and TENS (Frequency-100 HZ, Pulse duration50microsecond) were given to the subjects using four electrodes placed covering the L1 to S2 areas for 15 minutes. PPT was taken from right erector spine muscle targeted as the central area of stimulation via mechanical algometer. Results: Data of 20 subjects were analyzed using SPSS 16 version. Paired t-test applied to see difference within the group and unpaired t-test applied to see difference between the groups. Mean difference is PPT scores in kgf were IFT (baseline=2.77±0.43, 15min=3.53±0.43, 60min=3.29±042), TENS (baseline=2.72±0.43.15min=3.53±0.41, 60min=2.96±0.42). Difference between baseline and 15min (IFT=0.76±0.27, TENS=0.62±0.28, p=0.13). Difference between baseline and 60min (IFT=0.51±0.22, TENS=0.24±0.19, p<0.05). There was no significant difference found between IFT and TENS PPT score after 15 min. But there is significant difference found IFT and TENS PPT score after 60 min. Conclusion: Both TENS and IFT increased the pressure pain threshold to a similar extent immediately after stimulation. However, the poststimulation effect of interferential current lasted longer than that of transcutaneous electrical nerve stimulation at 60 minute.
Subunits and substrates of the anaphase-promoting complex.

The initiation of anaphase and exit from mitosis depend on a ubiquitination complex called the anaphase-promoting complex (APC) or cyclosome. The APC is composed of more than 10 constitutive subunits and associates with additional regulatory factors in mitosis and during the G1 phase of the cell cycle. At the metaphase-anaphase transition the APC ubiquitinates proteins such as Pds1 in budding yeast and Cut2 in fission yeast whose subsequent degradation by the 26S proteasome is essential for the initiation of sister chromatid separation. Later in anaphase and telophase the APC promotes the inactivation of the mitotic cyclin-dependent protein kinase 1 by ubiquitinating its activating subunit cyclin B. The APC also mediates the ubiquitin-dependent proteolysis of several other mitotic regulators, including other protein kinases, APC activators, spindle-associated proteins, and inhibitors of DNA replication.
The dynamic structure of everyday life

Computational theories of action have generally understood the organized nature of human activity through the construction and execution of plans. By consigning the phenomena of contingency and improvisation to peripheral roles, this view has led to impractical technical proposals. As an alternative, I suggest that contingency is a central feature of everyday activity and that improvisation is the central kind of human activity. I also offer a computational model of certain aspects of everyday routine activity based on an account of improvised activity called {\it running arguments} and an account of representation for situated agents called {\it deictic representation}.
Wind power-aware vehicle-to-grid algorithms for sustainable EV energy management systems

Renewable energy carriers such as wind or solar radiation turn out to be serious alternatives to fossil and nuclear energy production. However, due to its fluctuating characteristics its application within power grids leads to new challenges for system operators. That includes the intermediate storage of the energy which necessitates the installation of new systems or approaches. One of them is the usage of electric vehicle batteries which can be aggregated to virtual power plants. In this paper we propose an energy management algorithm which schedules the optimal charging and discharging times of an electric vehicle battery according to the expected fraction of regenerative energy within the power grid. At the same time the constraints of other stakeholders (driver, charging station infrastructure provider) are taken into account, enabling the algorithm to support the user in his charging decisions upon his daily mobility requirements. In the course of the paper we provide a detailed description of the algorithm, simulation results based on this approach and discuss its application in a field test we have performed, recently.
A Handwritten French Dataset for Word Spotting: CFRAMUZ

We present a new and freely available dataset, CFRAMUZ, for segmentation-free word spotting research. The dataset consists of seven novels with a total number of 64 pages and 18000 words written in french by the Swiss writer C.F. Ramuz. The novels cover the writer's whole period of life, therefore they show changes in the handwriting style. Together with the complete ground-truth of the dataset we provide an annotation tool. We provide evaluations of state-of-the-art word spotting approaches on this dataset. For completeness we also compare all the approaches on other commonly used datasets to demonstrate the new difficulties and challenges our new dataset introduces.
Documenter le jugement des enseignants en langue seconde au 3e cycle du primaire au Québec dans le cadre du bilan des apprentissages de fin de cycle

Cette etude vise a decrire les pratiques evaluatives d’enseignantes en langue seconde en fin de scolarite a l’ecole primaire au Quebec. Elle a pour but de cerner la prise en compte des resultats a l’epreuve ministerielle et des resultats obtenus tout au cours du cycle lors du jugement porte au bilan des apprentissages. Deux etudes de cas serviront a documenter leur jugement professionnel face a la tension lors de la confrontation de resultats divergents.
The self-grounded Bow-Tie antenna

The self-grounded Bow-Tie is a new type ultra-wide band (UWB) small antenna. It is compact, simple and has low profile and directional UWB radiation characteristics. Simulations and measurements have shown its ultra-wideband performance, such as about −10 dB reflection coefficient and stable radiation patterns over a frequency range of 2 – 15 GHz, and good time-domain impulse response. Penetration ability of the antenna through a concrete wall has been also tested. Compared to a Vivaldi antenna, the test shows the superiority of the self-grounded Bow-Tie to the Vivaldi.
Interplay of cell proliferation and cell death in Drosophila tissue regeneration

Regeneration is a fascinating process that allows some organisms to reconstruct damaged tissues. In addition to the classical regeneration model of the Drosophila larval imaginal discs, the genetically induced tissue ablation model has promoted the understanding of molecular mechanisms underlying cell death, proliferation, and remodeling for tissue regeneration. Recent studies have also revealed that tissue injury responses occur not only locally but also systemically, even in the uninjured region. Genetic studies in Drosophila have demonstrated the dynamic role of the cell death‐induced tissue response in the reconstruction of damaged tissues.
Deferoxamine Improves Early Postresuscitation Reperfusion after Prolonged Cardiac Arrest in Rats

The no-reflow phenomenon and delayed hypoperfusion after transient cardiac arrest (CA) impede postischemic recovery. Activation of lipid peroxidation (LPO) after ischemia and reperfusion is considered one of the mechanisms responsible for such abnormalities. The present study investigates the influence of iron-dependent LPO inhibitor deferoxamine (DFO) on the cerebral perfusion after prolonged CA and resuscitation. Fourteen male Sprague-Dawley rats were subjected to 17 minutes of CA, induced by esmolol (an ultrashort-acting β-blocker) and apnea, followed by resuscitation by retrograde intraaortic infusion of oxygenated donor blood mixed with a resuscitation cocktail inside a vertical-bore 9.4-T magnetic resonance imaging (MRI) magnet. Animals were randomized double-blindly into two groups to receive DFO or saline, respectively. Cerebral perfusion was measured by MRI continuously using the arterial spin-labeling method before, during, and after CA. All animals were successfully resuscitated in 1.36 ± 0.04 minutes with well-controlled arrest time (17.99 ± 0.03 minutes) in both groups. Deferoxamine significantly increased cerebral perfusion in hippocampus, thalamus, hypothalamus, and amygdala, but not in cortex, during the first 20 minutes of reperfusion. In the DFO-treated group, the neurologic deficit score was significantly better (400 ± 30 vs. 250 ± 47, out of 500 as the best, P < 0.05) and weight loss was significantly less (33 ± 6 vs. 71 ± 19 g, P < 0.05) 5 d after arrest. The finding supports the notion that early reperfusion immediately after resuscitation is important for long-term outcome and that LPO may be involved in microvascular disorders during the reperfusion, particularly in the brain after prolonged cardiac arrest and resuscitation.
The maximal error capacity of arbitrarily varying channels for constant list sizes

The capacity of an arbitrarily varying channel (AVC) for list codes of arbitrarily small list rate under the maximal error criterion has previously been determined. The authors prove that for an AVC A, any rate R below the list code capacity C/sub 1/(A) is achievable with a particular list size dependent on A, R and Y, where Y is the output alphabet. >
Comparison of the Effects of Telmisartan and Olmesartan on Home Blood Pressure, Glucose, and Lipid Profiles in Patients with Hypertension, Chronic Heart Failure, and Metabolic Syndrome

We compared the effects of telmisartan and olmesartan in 20 patients with chronic heart failure and metabolic syndrome. The subjects underwent once-daily 40 mg telmisartan for at least 3 months before switching to once-daily 20 mg olmesartan for the next 3 months (post 1). They were then treated with 3 months of once-daily 40 mg telmisartan (post 2). Systolic and diastolic blood pressure in the early morning, plasma B-type natriuretic peptide, serum total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels were increased at post 1 (p<0.005, p<0.05, p<0.05, p<0.05, p<0.05, and p<0.005 vs. baseline, respectively) before returning to their baseline values at post 2. The changes in plasma B-type natriuretic peptide levels correlated significantly with the shifts in systolic and diastolic blood pressure in the early morning at posts 1 and 2. Meanwhile, there were no fluctuations in either blood pressure in the late evening or in the outpatient room; nor were there fluctuations in heart rate. Simultaneously, neither serum high-density lipoprotein cholesterol nor fasting blood sugar levels differed significantly between posts. Moreover, telmisartan had more beneficial effects on glucose and lipid profiles in patients with relatively high HbA1c, serum total and low-density lipoprotein cholesterol, and triglyceride levels. Therefore, we concluded that telmisartan was more beneficial than olmesartan for controlling blood pressure in the early morning, as well as for improving glucose and lipid profiles in patients with hypertension, chronic heart failure, and metabolic syndrome.
In vivo cellular tropism of human T-cell leukemia virus type 1

To establish the phenotype of human T-cell leukemia virus type 1 (HTLV-1)-infected cells in peripheral blood, the polymerase chain reaction was used to detect and quantitate viral DNA in subpopulations of leukocytes obtained from patients with tropical spastic paraparesis and asymptomatic carriers. HTLV-1 could not be detected in peripheral blood mononuclear cells thoroughly depleted of T lymphocytes (E- CD3-), nor could it be detected in highly enriched populations of B lymphocytes (E- CD19+), monocytes (E- CD14+), or natural killer cells (E- CD16+). T lymphocytes were strongly positive for HTLV-1, and fractionation of this population revealed that 90 to 99% of the HTLV-1 DNA segregated with the CD4+ CD8- and CD45RO+ subsets. No difference between the cell type distribution of HTLV-1 in the asymptomatic carrier and the subjects with tropical spastic paraparesis was evident. Southern hybridization of genomic DNA prepared from the peripheral blood of HTLV-1 carriers indicated that up to 10% of circulating leukocytes may carry the HTLV-1 provirus.
Symlnfer: Inferring program invariants using symbolic states

We introduce a new technique for inferring program invariants that uses symbolic states generated by symbolic execution. Symbolic states, which consist of path conditions and constraints on local variables, are a compact description of sets of concrete program states and they can be used for both invariant inference and invariant verification. Our technique uses a counterexample-based algorithm that creates concrete states from symbolic states, infers candidate invariants from concrete states, and then verifies or refutes candidate invariants using symbolic states. The refutation case produces concrete counterexamples that prevent spurious results and allow the technique to obtain more precise invariants. This process stops when the algorithm reaches a stable set of invariants. We present Symlnfer, a tool that implements these ideas to automatically generate invariants at arbitrary locations in a Java program. The tool obtains symbolic states from Symbolic PathFinder and uses existing algorithms to infer complex (potentially nonlinear) numerical invariants. Our preliminary results show that Symlnfer is effective in using symbolic states to generate precise and useful invariants for proving program safety and analyzing program runtime complexity. We also show that Symlnfer outperforms existing invariant generation systems.