Miracle-dz/UniFAR-FTUs huggingface dataset:
Rôle de l'évaluation formative dans le cadre du soutien à l’apprentissage autorégulé en classe de français

The aim of this collaborative action research was to understand and support self-regulated learning when reading texts in L1 classes (French). Learning Through Reading (LTR) is a process that requires from students to self-regulate his / her learning while processing the information read in order to appropriate disciplinary knowledge and to carry out the learning activity (Cartier, 2006). In the context of the diversification of information media, LTR is increasingly using various semiotic modes (Lebrun, Lacelle & Boutin, 2012). In order to promote support for LTR in a multimodal context, a collaborative problemsolving approach developed with school personnel has been implemented (Cartier, 2016). Its initial phase is the analysis of the situation. The latter mobilizes the formative evaluation of the LTR process in a given activity. However, how do teachers in the French class assess the LTR process of students interacting with the specificities of the activity, as an initial phase in the adjustment of their teaching? A case study in an elementary class shows that this analysis suggests elements of concordance and discordance between the points of view of the students and the teacher on the LTR process. The adjustments to be made to teaching, as identified by the teacher, attempt to remove the points of discrepancy. This result is important because it shows that the coherence observed in the teacher is in the sense of sharing a common point of view with her students, the main actors of their learning.
Évaluation du NGAL (Neutrophil Gelatinase-Associated Lipocalin) plasmatique comme facteur prédictif précoce d’insuffisance rénale aiguë en post-opératoire de chirurgie aortique

L’insuffisance renale aigue (IRA) est une complication frequente et potentiellement grave en post-operatoire d’une chirurgie aortique juxta et supra-renale. Le biomarqueur de reference, la creatinine plasmatique est d’apparition tardive et son augmentation traduit une dysfonction renale avec des lesions nephroniques deja constituees. Le NGAL plasmatique (Neutrophil Gelatinase-Associated Lipocalin) est un temoin direct de l’agression renale per-operatoire. Depister precocement les lesions renales, permettrait de limiter les facteurs d’agression conduisant a l’IRA post-operatoire. L’objectif de notre etude etait d’evaluer le NGAL comme facteur predictif precoce d’IRA en post-operatoire de chirurgie aortique avec clampage supra-renal. Methodes : Nous avons realise une etude mono-centrique prospective observationnelle sur 25 patients operes d’un anevrisme de l’aorte juxta ou supra-renal entre Fevrier 2015 et Mars 2017. Le NGAL plasmatique etait dose 3 heures apres le declampage aortique total. L’IRA etait definie par les criteres AKIN (Acute Kidney Injury Network) a 48h de la chirurgie. Le taux de NGAL plasmatique etait compare entre les patients avec et sans IRA. Resultats : L’âge moyen etait de 66,1 ± 6,4 annees. Nous avons inclu 14 anevrismes juxtarenaux (AJR) et 11 anevrismes supra-renaux (ASR). Onze patients (44%) ont presente une IRA a 48h de la chirurgie. Aucun patient de notre cohorte n’a eu recours a l’epuration extra-renale. Il n’y a eu aucun deces a 30 jours post-operatoire. Les temps d’ischemies renales bilaterales etaient similaires dans les deux groupes (30,2 ± 12 minutes vs 22,3 ± 5,9 minutes ; p=0,10). Quinze patients ont beneficie d’une perfusion froide sur au moins une artere renale. Les taux pre-operatoires (T0) de NGAL etaient identiques dans les groupes IRA et sans IRA (87,4 ± 39,2 ng/ml vs 71,3 ± 36,9 ng/ml ; p=0,28). L’augmentation des taux de NGAL entre T0 et H3 etait significative pour l’ensemble de la cohorte (p Conclusion : Dans notre etude, l’elevation du taux de NGAL plasmatique n’etait pas associee au developpement d’une IRA a 48h d’une chirurgie aortique. Les comorbidites associees a la pathologie anevrismale peuvent en partie expliquer ce manque de performance. Cependant le caractere precoce de l’augmentation de ce biomarqueur en cas d’agression renale ischemique a ete valide.
Wavelength‐Dependent Stiffening of Hydrogel Matrices via Redshifted [2+2] Photocycloadditions

Hydrogels with on‐demand tunable mechanical properties within sensitive biological environments are of critical importance for examining cellular responses to cell culture platforms. Herein, the first bio‐orthogonal hydrogel that can be formed and subsequently tuned in its mechanical properties by simply switching different wavelengths of visible light (i.e., 455 and 420 nm) is reported. Specifically, both the initial hydrogelation and the tuning of the mechanical properties can be fully decoupled and selectively initiated by different colors of light. Sparing the need for any catalysts, the development of such a dual wavelength selective hydrogel for biological applications spans four levels: First, the development of the until today most redshifted photocycloaddition to allow for the selective initiation of only one photoreaction; second, the investigation of its wavelength‐dependent ligation efficiency; third, translation of the ligation chemistry into a hydrogelator, and fourth, establishing a biocompatible hydrogel platform for applications in biomaterials engineering including detachment of fibroblasts from 2D culture areas or primary 3D culture of human mesenchymal stem cells. The introduced platform technology enables the fabrication of a hydrogel of predefined mechanical properties exclusively with visible light.
Validity Test of Implicit Capital Cost Valuation Model—Based on China’s A-Share Market

Equity capital cost plays an important role in investment strategies and asset valuation, but there is no recognized valuation model and unified model validity test method in academia so far. This paper measures the cost of equity capital of A-share listed companies in China by using five kinds of implicit capital cost valuation models widely used by domestic scholars, and tests the validity of the model from the economic and statistical perspectives. It is found that the estimated values of the five models are significantly positively correlated with the realized returns one to three years in advance. Statistical tests show that OJ, PEG and MPEG models are more effective in explaining the time series of expected returns, while OJ models are more effective in explaining the cross-sectional changes of expected returns. Therefore, OJ model can be used as an effective model to measure the cost of equity capital of A-share listed companies in China.
The development of a one day preceptorship workshop for registered nurses in the emergency department

Background: Every year health care organizations conduct orientation sessions for nurses who are entering or transitioning into a new or unfamiliar area of practice. The Emergency Department (ED) is an area where there is a high turnover rate of nurses. Research has shown that preceptorship programs can decrease costs associated with high nurse turnover rates and ongoing nursing orientations, improve patient health care outcomes, support nurse’s transition into the new areas of practice, and foster the retention of highly qualified nurses in the ED. The Scarborough Hospital (TSH) ED provides emergency services to 110,000 numbers of people annually and would benefit from the implementation of a structured preceptorship program. Purpose: The purpose of this practicum is to develop a one-day preceptorship program that would prepare nurses to be effective preceptors in the emergency room at TSH. Methods: A literature review and consultations with key stakeholders guided the development of the preceptor workshop. Benner’s Novice to Expert Theory (1984), Knowles Theory of Andragogy (1984) and Morrison, Ross, Kalman, and Kemp’s (2013) Model of Instructional Design were used to guide the development of the preceptorship workshop. Results: ED preceptors need a structured preceptorship workshop that addressed their learning needs. A one- day preceptorship workshop comprised of six key sessions was developed that included an overview of preceptorship, teaching and learning strategies, conflict resolution techniques, methods to provide effective feedback, how to develop critical thinking and foster socialization to the ED. The advanced nursing competencies: clinical practice, research, leadership, consultation and collaboration were achieved throughout the process.
ICONS II: Identifying Continence OptioNs after Stroke randomised controlled trial

Lois Thomas, Christine Roffe, Joanne Booth, Christopher Chapple, Caroline Watkins, Brenda Roe, Christopher Sutton, Bruce Hollingsworth, Ceu Mateus, David Britt, Cliff Panton and Kina Bennett; for the MRC Continence Programme and R&D Stroke and Incontinence Study
The criteria of the identification of metabolic obesity among people with normal body weight and their use in everyday practice

Obesity and the metabolic syndrome caused by it constitute one of the biggest health issues of the 21st century. However, a problem of “a concealed form of obesity” — metabolic obesity with a normal body weight, which manifests clinically through the occurrence of metabolism disorders related to obesity among people with a normal body mass index — was pointed out in the 1980s. This affliction entails similar health consequences and causes many more problems in diagnosis and early treatment because a lack of obesity does not make doctors search for the traits of metabolic syndrome among seemingly healthy patients. The aim of this study is to present a proposition of diagnostic criteria for this disease in the historical perspective and to consider the possibilities of their use in everyday clinic practice.
Linguistic features in writing quality and development: An overview

: This paper provides an overview of how analyses of linguistic features in writing samples provide a greater understanding of predictions of both text quality and writer development and links between language features within texts. Specifically, this paper provides an overview of how language features found in text can predict human judgements of writing proficiency and changes in writing levels in both cross-sectional and longitudinal studies. The goal is to provide a better understanding of how language features in text produced by writers may influence writing quality and growth. The overview will focus on three main linguistic construct (lexical sophistication, syntactic complexity, and text cohesion) and their interactions with quality and growth in general. The paper will also problematize previous research in terms of context, individual differences, and reproducibility.
Raman characterization of the simulated control blade debris to understand the boric compounds transformations during severe accidents

(i) the direct oxidation of B 4 C by hot steam and (ii) the dissolution of B 4 C in stainless steel melt. Which process is dominant and which special features the degradation of B 4 C control blade in case of Japanese BWRs would have in oxidative or steam-starved environment is not easy to predict. Recently, debris analysis after control blade degradation tests uncovered effects, which were difficult to explain in the framework of present understanding (Pshenichnikov et al., 2019b), (Pshenichnikov et al., 2019c). In particular, SS-melt stratified after reaction with B 4 C with a formation of Cr-rich metallic layer surrounding an agglomerate of Abstract In order to address the challenge of the future Fukushima Dai-Ichi Nuclear Power Station (1F) debris characterization a new Raman spectroscopy investigation of simulated debris obtained after two control blade degradation tests CLADS-MADE-01 and CLADS-MADE-02 has been performed. A mechanism of the B 4 C degradation during the beginning phase of a severe accident until approximately 1873 K is described. A sequence of material interactions of B 4 C with stainless steel resulted in partial transformation of B 4 C granules into pure graphite, that later experienced oxidation with formation of CO x gas. Especially this mechanism is active during melting phase in oxidative environment. At the same time boron was associated with formation of new Cr-B-containing solid phases in liquid melt, that continued relocation depleted by Cr and B, which resulted in redistribution of elements within the degrading reactor core. This knowledge would provide new insights for understanding of the absorber blade degradation mechanism under specific accident conditions close to Fukushima Daiichi Unit 2 and Unit 3 reactors and especially would be helpful during potential characterization of metallic debris of 1F.
Various Aspects of Sentiment Analysis: A Review

Sentiment Analysis (SA) is the utmost progressive research field in natural language processing that focuses on identifying the emotions of a writer behind the series of words and classifies public attitude, opinion from visuals, audios and texts. This paper categorizes and presents a refined study of recently published articles related with sentiment analysis research. It demonstrates an outline of the prime issues and challenges, explores sentiment resources and discusses practical techniques and tools practiced in this context. It also provides an insight of various sentiment analysis applications in several different scenarios, current enhancements and describes the possible future directions for deeper understanding of human emotions.
The relationship between serum myeloperoxidase levels and major cardiovascular events in patients with acute coronary syndrome

Study design: Serum MPO levels were measured by ELISA on admission of 243 consecutive patients with acute coronary syndrome (153 acute myocardial infarction, 90 unstable angina). Major cardiac events that occurred during hospitalization and 30-day follow-up period included recurrent angina, reinfarction, ventricular (ventricular tachycardia, ventricular fibrillation) and supraventricular (atrial fibrillation, supraventricular tachycardia) arrhythmias, complete atrioventricular block, clinical heart failure, and death. Correlations were sought between high (n=70, >350 μg/l) and low (n=173, ≤350 μg/l) MPO levels and major events. Relative risks were estimated using the Cox proportional hazards regression model.
VP26 Comparing Statistical Methods For Meta-Analysis Of Rare Event Data

INTRODUCTION: We aimed to identify the validity and robustness of effect estimates for serious rare adverse events in clinical study reports of antidepressant trials, across different meta-analysis methods for rare binary events data (1,2). METHODS: Four serious rare adverse events (all-cause mortality, suicidality, aggressive behaviour and akathisia) were meta-analyzed using different methods (3). The Yusuf-Peto odds ratio (OR), which ignores studies with no events in the treatment arms, was compared with the alternative approaches of generalized linear mixed models (GLMM), conditional logistic regression, a Bayesian approach using Markov Chain Monte Carlo (MCMC) and a beta-binomial regression model. RESULTS: Though the estimates for the four outcomes did not change substantially across the different analysis methods, the Yusuf-Peto method underestimated the treatment harm and overstimated its precision, especially when the estimated odds ratio (OR) deviated greatly from 1. For example the OR for suicidality for children and adolescents was 2.39 (95 percent Confidence Interval, CI 1.32 to 4.33, using the Yusuf-Peto method), but increased to 2.64 (95 percent CI 1.33 to 5.26) using conditional logistic regression, to 2.69 (95 percent CI 1.19 to 6.09) using beta-binomial, to 2.73 (95 percent CI 1.37 to 5.42) using the GLMM and finally to 2.87 (95 percent CI 1.42 to 5.98) using the MCMC approach. CONCLUSIONS: The method used for meta-analysis of rare events data influences the estimates obtained and the exclusion of double zero-event studies can give misleading results. To ensure reduction of bias and erroneous inferences, sensitivity analyses should be performed using different methods and we recommend that the Yusuf-Peto approach should no longer be used. Other methods, in particular the beta-binomial method that was shown to be superior, should be considered instead.
Holocene vegetation and climate change on the Colorado Plateau in southern Utah, USA

Abstract Pollen, plant macrofossils, and sedimentary analyses from archaeological deposits at North Creek Shelter (NCS) on the Colorado Plateau provide data on vegetation and climate change during the Holocene. From 11,300–10,200 cal yr BP, NCS was embedded in a mixed conifer forest of cool-adapted species (e.g., Abies, Pseudotsuga menziesii, and Pinus ponderosa) with an Artemisia understory. During this interval, NCS pollen corresponds to modern pollen from Picea–Abies forests that reside 950 m higher in elevation. Rapid deposition rates of NCS sediments indicate that climatic conditions during the Early Holocene were more mesic than today, with increased precipitation. The onset of warmer conditions at NCS began at 10,200 cal yr BP, and pollen and plant macrofossils indicate that a semiarid woodland and scrub mosaic dominated by Pinus edulis, Juniperus osteosperma, and Amaranthaceae surrounded NCS by 9300 cal yr BP. This is corroborated by fossil pollen that is similar to modern pollen from P. edulis–J. osteosperma woodlands and Amaranthaceae scrub that currently surround NCS. Sedimentary analyses suggest that during this time, accumulation rates were very low due to low precipitation and a drier climate overall. Migration of P. edulis into southern Utah is directly dated to 8100 cal yr BP, thus confirming recently proposed patterns of northward expansion.
Nonclinical pharmacological characterization of a focal adhesion kinase inhibitor, PF-562,271

5430 Cancer cells are characterized by the ability to grow in an anchorage-independent manner. This characteristic phenotype is due, in large part, to the activity of the non-receptor tyrosine kinase, focal adhesion kinase. FAK localizes in focal adhesion plaques and has a role as a scaffolding and signaling protein for other adhesion molecules. As such, FAK acts as a signaling molecule for many integrins which do not have intrinsic kinase activity, as well as, complimenting signal transduction through other RTKs (e.g. EGFR, VEGFR). Recent studies demonstrate a strong correlation between increased FAK expression and the invasive phenotype of aggressive human tumors. There has been some controversy regarding the importance of the kinase activity relative to the scaffolding functions of FAK. PF-562,271 is a potent ATP competitive, reversible inhibitor of FAK and Pyk2 kinase with IC 50 of 1.5 and 14 nM, respectively. PF-562,271 is potent in an inducible cell based assay* measuring phospho-FAK with an IC 50 of 5 nM. PF-562,271 was evaluated against a multiple kinases and displays >100x selectivity against a long list of non-target kinases. PF-562,271 inhibits FAK phosphorylation in vivo in a dose dependent fashion (calculated EC 50 35 ng/mL, free, 0.5-4 hrs post dose) following oral administration to tumor bearing (nu/nu) mice. In vivo inhibition of FAK phosphorylation was sustained (56%) for over 4 hours with a single oral dose of 33 mg/kg. Antitumor efficacy was evaluated in the following human s.c. xenograft models: PC-3M (prostate), BT474 (breast), BxPc3 (pancreatic), LoVo (colon), U87MG (glioblastoma), and H460 (lung). Regressions were observed in PC-3M, BT474, BxPc3, and LoVo models at doses of 25-50 mg/kg, BID corresponding to Cmax (free) ranges of 77-885 ng/ml, Cave (free) of 14-40 ng/ml, and inhibition of phospho-FAK of 31-76% for >4 hours. Maximum tumor growth inhibition in the U87MG tumor was 51% using an osmotic mini-pump corresponding to a Css of 0.7 ng/mL (free) with a concomitant decrease in phospho-FAK of 45%. No weight loss, morbidity, or mortality were observed in any TGI experiment (up to 50 mg/kg BID x 28 days or 100 mg/kg QD x 25 days). Tumor growth inhibition was dose and drug exposure dependent. BID dosing and mini-pump experiments (Css) resulted in greater tumor growth inhibition in multiple models compared to QD dosing (equivalent total daily dose) suggesting Cave and the time above the Cave are more relevant to efficacy than Cmax. Based on the Cave from TGI and PD experiments (at 50% of inhibition), the efficacious concentration (free) ranges from 4-14 ng/ml. Taken together, these data demonstrate that kinase inhibition with an ATP competitive small molecule inhibitor of FAK results in robust anti-tumor activity. This compound is presently in Phase I clinical trials (clinical data to be presented at 2007 ASCO). * Patent WO04027018 Inducible Focal Adhesion Kinase Cell Assay published 04/01/04
Effectiveness of Electronic Government in the Citizen-Centric Approach in Bandung City

This paper aims to exploit e-government effectiveness from the perspective of users by focusing on online-based business licensing services in Bandung City. This paper also aims to develop the E-government Citizen Satisfaction Framework proposed by Sigwejo and Pather (2016). The method used is a qualitative method in e-government research. The results show that there is a gap between the services provided and community expectations. Online-based business licensing services in Bandung City have not been fully effective and also have not fully given the benefits since licensing is still one of the obstacles in conducting business in Bandung City. The main findings in this paper are the three themes as a development of the e-government effectiveness model, namely users’ e-readiness, multi-channel delivery of e-government services, and the net impact. The implication of the main findings is that the integration of online services and offline services is required in accordance with the mapping of users’ e-readiness.
High Incidence of Hepatitis B Virus Infection in Hemodialysis Patients at Sanglah General Hospital and It’s Risk Factors

Background : Patients receiving maintenance hemodialysis (HD) are at higher risk for Hepatitis B Virus (HBV) infections than in general population. Strict infection control is essential to prevent nosocomial transmission. We aimed to investigate the incidence of HBV infection in the HD population in Sanglah General Hospital as well as risk factors acquired HBV infection. Method : All adult patients receiving maintenance HD (n=267) in 3 dialysis units at Sanglah Hospital were studied between March to June 2016. In this study, medical record of patients on maintenance hemodialysis were reviewed and the patients were interviewed by the researchers to collect data regarding the serology status of these patients before and during HD, and potential risk factors which could be associated with HBV acquisition. Results : Participant mean age was 54.07 ± 0.80 years and 154 (57.7%) were male.We found 21 patients (7.8%) were sero-positive for HBV (HBsAg positive) with mean titer was 9.26±1.85. Of the sero-positive patients,1 patient (4.8%) were known to be infected before the initiation of HD and 20 patients (95.2%) were infected during HD. Incidence of HBV infection during HD was 7.5% (20/266). Sero-positive patients were younger with mean age was 51.81±2.76 years, had longer time on dialysis and had previous blood transfusions. Risk factors, which significant associated with hepatitis B infection were history of transfusion (p<0.01; OR: 2.49; 95%CI: 1.29-8.18) and duration of hemodialysis (p < 0.01; OR: 1.07; 95% CI: 1.03-3.74). Conclusion : Patients on maintenance HD in Sanglah General Hospital have a high incidence of HBV infection. The factors associated with HBV infection are highly suggestive of nosocomial transmission within HD units. History of transfusion and duration of hemodialysis were significant risk factors for HBV infection in patients receiving maintenance HD.