Miracle-dz/UniFAR-FTUs huggingface dataset:
Vers une meilleure exploitation du potentiel enzymatique et métabolique de Metschnikowia pulcherrima et Torulaspora delbrueckii pour la production d’arômes en fermentation oenologique

Au cours de fermentations spontanees, de nombreuses levures indigenes de la flore du mout de raisin sont impliquees dans les premieres etapes du procede de vinification. Ces levures, peu adaptees aux fortes concentrations en ethanol et aux limitations en oxygene, sont par la suite remplacees par S. cerevisiae dont la presence est necessaire au bon deroulement de la fermentation. Neanmoins, les levures non-Saccharomyces peuvent contribuer de facon positive a la qualite organoleptique des vins. L'objectif general de cette these est d’apporter de nouvelles connaissances sur la physiologie de Torulaspora delbrueckii et Metschnikowia pulcherrima, deux levures non-Saccharomyces distribuees par la societe Lallemand, afin de mieux exploiter leurs potentialites en fermentation oenologique, notamment pour la production d'aromes. Une premiere partie du projet a ete dediee a l’etude du metabolisme de T. delbreuckii et M. pulcherrima, tout d’abord en determinant leurs performances fermentaires et leur production d’aromes en utilisant differentes sources d’azote. Des proprietes specifiques a T. delbreuckii et M. pulcherrima ont ete identifiees au niveau de la capacite de consommation des composes azotees et du profil de formation des aromes, meme si de facon globale, l’incidence de la nature de la source d’azote est similaire a celle de S. cerevisiae. Le devenir de certains acides amines dans le reseau metabolique a ensuite ete elucide par des approches de tracage isotopique, montrant une gestion differente des acides amines par les deux levures non-Saccharomyces : vers la biosynthese des proteines pour T. delbreuckii et vers la formation d’alcools superieurs pour M. pulcherrima. La deuxieme partie du projet a porte sur l’etude des levures non-Saccharomyces en fermentation sequentielle avec S. cerevisiae, en fonction de la disponibilite en nutriments. Des variations dans la reponse de la production des aromes fermentaires et varietaux (thiols) aux teneurs en sucre, azote et lipides ont ete mises en evidence entre les deux modalites d’inoculation sequentielle et des fermentations de S. cerevisiae en souche pure, qui s’expliquent par des interactions entre S. cerevisiae et les levures non-Saccharomyces et leurs particularites metaboliques. Enfin, l’interet de l’utilisation de levures non-Saccharomyces a ete evalue en mout naturel, montrant la contribution positive de ces levures sur le profil aromatique des vins. Les connaissances apportees dans ce projet permettront de definir des strategies de gestion de la fermentation utilisant au mieux les proprietes de T. delbreuckii et M. pulcherrima pour produire des vins presentant une typicite aromatique marquee.
Thinking about the future of farming through different facets of “work in agriculture”. Textual analysis of papers from the first Symposium on Work in Agriculture

Thinking about the future of farming systems requires connecting multiple facets of changes in work in agriculture. The first International Symposium on Work in Agriculture was held in 2016 to discuss a variety of themes, from employment and health to gender and work organization. Textual analysis of the symposium’s proceedings was performed, identifying four research domains: the influences of 1) demographic and rural dynamics and changes on family involvement, 2) technical aspects of work on farm and work organization, 3) changes on work and new skills of agricultural advisors and 4) socio-technical changes on work in agriculture and agricultural models. Among these main domains, agroecological transition emerged as a key entry to study overall changes in farming and food systems. These elements will help to consolidate a vision of current hotspots of changes in work in agriculture and of major figures in research communities.
The Effects of Mutations are Modified by Genetic Background in Mice

Background: Commonly used genetic models of phenotype assume that alleles have similar effects in all individuals. Mounting evidence suggests that higher-order interactions, which may vary between populations, profoundly affect phenotypic variation. The effect of genetic and environmental perturbations may therefore differ across genetic backgrounds. In this manuscript, we develop a statistical test that determines whether the effect of a mutation on a complex phenotype changes as a function of ancestral background. Results: We apply our test to two large cohorts of mice and observe 49 significant gene by ancestry interaction associations across 14 phenotypes as well as over 1,400 Bonferroni-corrected gene by ancestry interaction associations in gene expression data. We also observe evidence of rapid selection pressure on individual polymorphisms within one of the cohorts. Conclusions: Unlike our prior work in human populations, we observe widespread evidence of ancestryspecific SNP effects, perhaps reflecting the greater divergence present in crosses among laboratory mice.
Evaluations of the antibacterial effect of chitosan edible film contain ajwain essential oil on some foodborne pathogenic bacteria

Biodegradable active packaging containing natural extracts derived from plants with antimicrobial properties is one alternative strategy that can be considered by the food packing industry to reduce the use of environmentally harmful synthetic polymers. Chitosan is a safe, natural, no allergen and biocompatible polymer with health benefits. The aim of this study was to investigate the effects of chitosan film containing different concentrations of ajwain essential oil on some foodborne pathogenic bacteria, including Listeria monocytogenes ATCC 19118, Bacillus cereus ATCC 11778, Staphylococcus aureus ATCC 65138 and Escherichia coli O157:H7 ATCC 25922, and Vibrio parahaemolyticus ATCC 43996 with disk diffusion method was evaluated. The results showed that by increasing the concentration of essential oil, the inhibition zone’s diameters were significantly expanded (p<0.05). The maximum and minimum antimicrobial effects of essential oil were observed against S. aureus (26.73mm) and E. coli O157:H7 (11.25 mm). The results of this study confirmed that the use of chitosan-based antimicrobial films incorporated with ajwain essential oil has a remarkable antibacterial effect and therefore it can be practical in active packaging in the food industry.
Life Skills to deal with Mental Health Issues in Women

Mental health plays a vital role in leading healthy and happy life in individuals. It refers to an overall psychological well-being, or an absence of a mental disorder. From the perspective of “positive psychology”, mental health may include an individual’s ability to enjoy life and create a balance between life activities and efforts to achieve psychological resilience. Women experience various mental health issues due to digitalization, interpersonal relationship issues and failure in daily activities such as difficulty in problem solving and decision making. In this paper, the author has attempted to shed light on the various mental health issues found in women in current scenario. Life skills training can be effective to tackle these issues. Life skills refer to the abilities that help to promote mental health and well-being. It includes abilities like decision making, problem solving and interpersonal relationship skills etc. These are found to be effective in dealing with the difficult situations which may lead to mental illness. Life skills training particularly to deal with these issues would help women to promote mental health and balance in their life. Moreover author has also attempted to establish that life skills intervention program cultivate the necessary skills that help in maintenance of mental health in women. Development of these abilities would help women to adjust with the changes in environment occurring due to digitalization, establish positive relationships and show efficiency in problem solving and decision making.
PERFORMANCE ANALYSIS OF A REAL-TIME ADAPTIVE PREDICTION ALGORITHM FOR TRAFFIC CONGESTION

Traffic congestion is a major factor to consider in the development of a sustainable urban road network. In the past, several mechanisms have been developed to predict congestion, but few have considered an adaptive real-time congestion prediction. This paper proposes two congestion prediction approaches are created. The approaches choose between five different prediction algorithms using the Root Mean Square Error model selection criterion. The implementation consisted of a Global Positioning System based transmitter connected to an Arduino board with a Global System for Mobile/General Packet Radio Service shield that relays the vehicle’s position to a cloud server. A control station then accesses the vehicle’s position in real-time, computes its speed. Based on the calculated speed, it estimates the congestion level and it applies the prediction algorithms to the congestion level to predict the congestion for future time intervals. The performance of the prediction algorithms was analysed, and it was observed that the proposed schemes provide the best prediction results with a lower Mean Square Error than all other prediction algorithms when compared with the actual traffic congestion states.
Public awareness of zoonotic diseases and public health implications in Makurdi Metropolis, Benue State, Nigeria.

This study was conducted with the objectives of assessing the level of awareness on zoonotic diseases among residents of Makurdi Metropolis. Questionnaire was structured into 3 sections namely, socio- demographic characteristics of residents, Awareness on domestic animals, and wild animals transmission of zoonotic diseases. Simple and systematic random sampling was used to select sample locations in which a total of 250 questionnaires were administered; Descriptive statistics, Students t-test and chi-square analysis were used to analyzed data. Field result showed that 144 respondents male were interviewed while 106 respondents were female. Residents of Makurdi Metropolis were quite aware of zoonotic diseases in both domestic and wild animals. The commonest domestic animal zoonotic diseases known to residents were: the Mad Dog disease, Bird Flu and Swain Flu. While the commonest wild animal zoonotic diseases known to residents were: Monkey Pox disease, Ebola disease, and Lassa fever, the awareness of residents on these zoonotic diseases could be associated with the recent outbreak of these diseases and in the area . It was therefore recommended that more awareness campaigns on other types of zoonotic diseases and they preventive measures should be given to residents of Makurdi metropolis to forestall future public health hazards.Keywords: Makurdi metropolis, zoonotic diseases transmission, Awareness, domestic and wild animals.
The Impact of Pemberdayaan Ekonomi Umat (PPEU) YBM PLN Program in Merapi Merbabu Complex: Working Capital Loan based on Lariba Operates

People who do not have capital and assets really expect a loan without interest. However, it is almost impossible for financial institutions to disburse loans without interest. They eventually became entangled in loan sharks to get a capital loan which caused them to live in riba for years. This is the background of the Yayasan Baitul Maal (YBM) PLN present in the midst of the community through the Pesantren Merapi Merbabu Community by launching the Program Pemberdayaan Ekonomi Umat (PPEU) in the form of farm capital loans without riba. The purpose of this study was to determine the impact assessment of Program Pemberdayaan Ekonomi Umat. This research uses quantitative methods through filling out questionnaires by 83 beneficiaries and the qualitative method was carried out by interviews and Focuss Group Discusions. Program impact evaluation is measured using SLIA (Sustainable Livelihood Impact Assessment) and MSC (Most Significant Change). The results of the study showed that beneficiaries were very satisfied with the “Farm Capital Loan without riba" program they received with an average score of 86%. Meanwhile the results of the evaluation from 5 aspects SLIA are as follows: the economic aspect increases by 0.5, the social aspect rises by 0.6, the da'wah aspect rises by 2.0, the spiritual aspect rises by 1.4, and the human resource aspect rises by 0.8. The results of this study are expected to recommendation for relevant stakeholders in order to optimize the community's economic improvement program.
Variation of kerogen assemblages and δ13CKerogen in Lower Toarcian successions of the southern Tethyan margin

The early Toarcian Oceanic Anoxic Event (T-OAE) is associated with an “excess” of C12 in the atmospheric and ocean carbon reservoirs and widespread occurrence of organic-rich facies around the globe. The T-OAE is recorded as a pronounced negative carbon isotopic excursion (CIE) in carbonates, fossil wood, and kerogens at the base of the Serpentinum (=Falciferum=Levisoni) Chronozone, positioned within a broad δ13C positive trend initiated at the base of the Lower Toarcian. Contrasts in deposition and preservation of OM between the northern and southern Tethyan margins are observed during the T-OAE. Several sections of the northern Tethyan margin are enriched in OM, whereas in the southern Tethyan margin, organic-rich facies are spatially and temporally restricted and have lower TOC. This dichotomy reflects differentiated depositional and environmental conditions between the two margins, controlled by the interplay of local, regional, and global constraints (distinct palaeogeographical location, OM type and source, palaeoceanography, climate, tectonics, etc.). This study investigates the variation of kerogen assemblages and δ13CKerogen in the Upper Pliensbachian–Lower Toarcian interval along the southern Tethyan margin, i.e. Lusitanian Basin (Portugal), Betic Cordillera (Spain), and Middle Atlas (Morocco). The objective is to contribute to the understanding of the paleoenvironmental variables and dynamics that influenced deposition and preservation of OM during the Late Pliensbachian–Early Toarcian in the Tethyan region. Preliminary analysis revealed that Upper Pliensbachian–Lower Toarcian kerogen assemblages from the Betic Cordillera, Lusitanian, and Middle Atlas basins are dominated by terrestrial particles (phytoclasts and sporomorphs) and have relatively more positive δ13C values when compared with correlative North-European sections. In the Lusitanian Basin and Betic Cordillera, the T-OAE negative CIE is observed in the δ13CKerogen record and is accompanied by an increase in terrestrial palynomorphs, non-opaque phytoclasts (NOP), and cuticle fragments. These increases are in line with the posited intensification of continental weathering, acceleration of the hydrological cycle, and increased export of terrestrial OM into marine environments during the T-OAE.
Relationship between Academic Stress and Internet Addiction among College Students

The present study assesses the relationship between the academic stress and internet addiction among college students studying in Mysuru city. Academic stress inventory (Lin & Chen, 2009) and Internet addiction test-IAT (Young, 1998) were administered to a sample of 120 college students. Academic stress of students was measured in 7 domains and internet addiction in 6 domains. Data were subjected to product moment correlation and stepwise multiple regression to find out the relationship between stress and addiction, including the domains of internet addiction which predict stress. Results revealed that a large majority of the students had moderate to high levels of internet addiction and academic stress. Almost all the domains of internet addiction were significantly and positively correlated with the domains of stress. Further, stepwise multiple regression revealed that out of the seven domains of stress, only Peer stress was the major predictor of stress. Strategies for decreasing the extent of stress and addiction among students have been delineated.
Thermal stimulation temperature is encoded as a firing rate in a Hydra nerve ring

Nervous systems are remarkable for supporting stable animal behavior despite dramatic changes to neurons’ number and connectivity. An ideal model organism to study this phenomenon would have: 1) dynamic neural architecture 2) transgenic reporters of neural activity, 3) a small, transparent body, and 4) well-defined sensory-motor behaviors. While Hydra vulgaris possesses the first three advantages, it currently lacks well-characterized sensory-motor responses. Here, we show the first quantitative measurements of Hydra’s behavioral responses to thermal stimulation and associated neural activity. Specifically, we find that Hydra elongate and then contract when heated. This behavior is accompanied by synchronous, periodic activity of neurons in the animal’s peduncle. We find that the frequency of these neural oscillations is nearly the same even if the number of neurons change by a factor of two. These observations suggest that Hydra provides a rich model for studying how animals maintain stable sensory-motor responses within dynamic neural circuit architectures. One sentence summary Here we show that Hydra have a group of thermally responsive neurons that encodes the absolute temperature of a thermal stimulus and that this encoding is independent of the number of neurons in the animal.
Application of Genetically Modified Mosquitoes (Anopheles Species) in the Control of Malaria Transmission

Mosquito species of the Anopheles gambiae complex represent the major vectors of human malaria and they pose an enormous burden on global health and economies. Every year 300–500 million people are infected by malaria and over a million people die as consequence of Plasmodium parasite infections. Disease endemic countries often do not have the economic resources and the logistics to sustain control efforts like the massive and prolonged use of insecticides, the use of Long Lasting Insecticide Treated Nets (LLITN), Indoor Residual Sprays (IRS), Larviciding (abortion of metamorphosis) and adequate environmental sanitation. New control strategies that have Review Article Joseph et al.; AJBGE, 1(1): 1-16, 2018; Article no.AJBGE. 40646 2 sustainable effects are desperately needed. This article, therefore, considered the unprecedented effort aimed at generating new molecular tools and a comprehensive knowledge of biology and the genetics of Anopheline mosquitoes which has culminated in the sequencing of the A. gambiae genome and development of gene transfer technology for a series of vectors species. The article also looked into the molecular advances that have been made to express genes that can block the transmission of Plasmodium in model systems or express traits facilitating the implementation of sterile insect techniques for vector control.
Status and progress of apatinib in treatment of malignant tumors

In recent years, anti-angiogenic drugs influencing vascular endothelial growth factor receptor (VEGFR) and vascular endothelial growth factor (VEGF) signaling have been widely used in the treatment of malignant tumors. Apatinib is an orally bioavailable small molecule antiangiogenic agent. The CSCO Guide to Gastro-Oncology, published in 2017, lists apatinib as the only targeted drug targeted for third-line treatment of gastric cancer. This review summarizes the recent advances in the structure, mechanisms of action, reversing drug resistance, clinical efficacy, adverse reactions, and biomarkers in various types of malignancies. Key words: Neoplasms; Apatinib; Resistance; Angiogenesis; Vascular endothelial growth factor receptor-2
Transformational Leadership and Job Satisfaction: A Confirmatory Study in the Banking Sector of Pakistan

The main purpose of the study was to identify TL `s effect on employees` JS Crosssectional research design was selected for the study. Study participants were 177 employees from forty-one (41) private banks of district Swat. The instrument used for the study were Multifactor Leadership Questionnaire (MQL) Form 6 developed by (Avolio & Bass, 1990), TL scale developed by Hartog, De Hoogh, and Kalshoven (2013) and JS scale developed by Spector (1994). A convenience sampling method was applied for data collection. Results of the study revealed a significant positive association between TL `s components (IM, IC, II, IS), and JS IM and IS were the best predictors of JS.
PROTECTIVE EFFECTS OF POMEGRANATE (PUNICA GRANATUM) PEELS ON THE PITUITARY GONADAL HORMONAL AXIS OF STREPTOZOTOCIN-INDUCED DIABETES IN ADULT MALE ALBINO RATS

Background: Type 1- diabetes mellitus more likely induces changes in the male reproductive system and alters the hormonal synthesis. Oxidative stress plays a crucial role in the pathophysiology of diabetic testicular dysfunction. Pomegranate (PG) is believed to have a variety of biologically active components with antioxidant properties. Objectives: Evaluating the effects of PG peels on the hypogonadism and steroidogenesis in streptozotocin (STZ)-induced diabetes in adult male rats. Materials and Methods: Forty adult male albino rats were divided into four equal experimental groups, i.e. control, non-diabetic-treated, diabetic and diabetic-treated. Diabetes was induced by a single dose of STZ injection. The treated rats received 100 mg/kg PG peels via oral gavages once daily for 10 weeks. At the end of the experimental period, blood samples were prepared for estimating fasting serum glucose (FSG), serum luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone (T) levels. Catalase (CAT), superoxide dismutase (SOD), glutathione (GSH) and steroidogenic enzymes (3β-HSD and 17β-HSD) activities were measured in the testicular homogenate. In addition, percentages of body weight (BW) gain and relative testicular weight were recorded. Results: STZ- induced diabetic rats exhibited decreases in BW gain, testis weight, LH, FSH, T, CAT, SOD, GSH, 3β-HSD and 17β-HSD levels. However, PG peels administration improved the hyperglycemia, increased the LH, FSH and T levels. Also, the antioxidant enzyme activities and steroidogenic enzymes increased. Conclusion: Diabetes had induced oxidative testicular dysfunction in adult rats and adversely affected the pituitary gonadal hormonal axis. Pomegranate peels has effectively reversed the diabetes- related testicular disturbances and improved gonadal steroidogenesis due to its antioxidant and antidiabetic effects.