Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect Of Strain On The Minerlization Of Individual Collagen Fibrils

1 Acknowledgements.2 Chapter 1 – Introduction . 5 Chapter 1.1 Clinical Relevance of Bone Scaffolds . 5 Chapter 1.2 Collagen . 7 Chapter 2 – Review of Literature . 9 Chapter 2.1 Collagen in Bone . 9 Chapter 2.2 Mechanical Properties of Tendon and Bone . 10 Chapter 2.3 in vitro methods of collagen mineralization . 13 Chapter 2.4 Collagen Fibril Mechanical Studies . 15 Chapter 2.4. 1 Nanoindentation via AFM . 15 Chapter 2.4. 2. Small-Angle X-Ray Scattering . 16 Chapter 2.4. 3 AFM-based force spectroscopy . 17 Chapter 3 – Experimental methods . 20 Chapter 3.1 Materials . 20 Chapter 3.2 Single Fibril Extraction and Mounting.22 Chapter 3.3 Microneedle Force Detection.26 Chapter 3.4 Mineralization Protocol.29 Chapter 3.5 Mechanical Testing.30 Chapter 3.6 Diameter Measurements via SEM imaging.31 Chapter 3.7 Analysis.32 Chapter 4 – Experimental Groups and Results.33 Chapter 5 – Discussion of Results.37 Chapter 5.1 Discussion.37 Chapter 5.2 Summary.38 References . 40
Screening for Depression in Adults: US Preventive Services Task Force Recommendation Statement.

DESCRIPTION Update of the 2009 US Preventive Services Task Force (USPSTF) recommendation on screening for depression in adults. METHODS The USPSTF reviewed the evidence on the benefits and harms of screening for depression in adult populations, including older adults and pregnant and postpartum women; the accuracy of depression screening instruments; and the benefits and harms of depression treatment in these populations. POPULATION This recommendation applies to adults 18 years and older. RECOMMENDATION The USPSTF recommends screening for depression in the general adult population, including pregnant and postpartum women. Screening should be implemented with adequate systems in place to ensure accurate diagnosis, effective treatment, and appropriate follow-up. (B recommendation).
The role of Codex Alimentarius Commission in controversy over genetically modified food

The Codex Alimentarius Commission (Codex) is the main international body responsible for adopting food safety rules. A particular problem is the issue of genetically-modified food since this topic has been in the public attention from the first instances of sowing genetically-modified crops in the mid-1990s. Because of the importance of the recommendations in the Codex, corporations are particularly interested in adopting the recommendations which cannot affect their profits – this is particularly evident in their effort to prevent the mandatory labelling of genetically-modified foods. In this chapter, through a brief historical overview of the process of labelling genetically-modified food, we will point to the complexity of this issue, which is manifested within a twentyyear process of issuing rules on labelling genetically-modified food.
Loyalty status of consumers to cigarettes brands and influencing factors in Bangalore City: A descriptive study

Background :Brand loyalty has been studied in many industries and countless product categories. Despite the fact, very few research here been conducted on the tobacco product category in India. The aim of this study was to determine the loyalty status of consumers to cigarettes brands and factors that influence the loyalty status groups. Design and methods:A descriptive study was conducted during the period of March 2017April 2017 among the smokers visiting VS Dental College & Hospital , Bangalore Karnataka. A total of 340 smokers participated in the study. Data was collected using a self administered questionnaire. Descriptive statistics with frequency and percentage was used to describe the data. Results :It was observed that, four main loyalty levels exist i.e. hardcore, softcore, shifters and switchers and have differe nt demographic characteristics and reasons for their loyalty status. The hardcore loyal gave their main reasons as high satisfaction derived quickly, affordable price and strong smell. The softcore reasons were; strength of the kick, similar menthol and same price. Conclusion:The study concluded that the loyalty status groups of smokers exist i.e. hardcore loyal, softcore loyal, shifters loyal and switchers. The reason behind the loyalty status groups is due to the nature of cigarettes and unique characteristics among the group of smokers.
Production of Amylase by Aspergillus niger Using Ziziphus as Substrates Employing Liquid Fermentation

International Journal of Pharmaceutical Sciences Review and Research Available online at www.globalresearchonline. net © Copyright protected. Unauthorised republication, reproduction, distribution, dissemination and copying of this document in whole or in part is strictly prohibited. 26 Mudiganti Ram Krishna Rao, Sathish Kumar M, Saranya Y, Divya D Department of Industrial Biotechnology, Bharath University, Selaiyur, Chennai, Tamil Nadu, India. *Corresponding author’s E-mail: mrkrao1455@gmail.com
Anesthetic Management of an Obese Child with Charcot-Marie-ToothDisease: A Case Study

Charcot-Marie-Tooth (CMT) disease is an inherited motor and sensory neuropathy predominantly affecting the feet and legs, with an estimated prevalence of one per 2500 (1). Some of anesthetic medications present varying degrees of potential risk for worsening CMT neuropathy. This is a case study of a 14-year-old, obese (body mass index= 36.5), male child known to have CMT disease and listed for urgent laparoscopic appendectomy. Obesity as a co-morbidity was an additional burden affecting the anesthetic management along with calculating the doses of anesthetic drugs.
Opening the black box of high resolution fish tracking using yaps

The R package yaps was introduced in 2017 as a transparent open source alternative to closed source manufacturer-provided solutions to estimate positions of fish (and other aquatic animals) tagged with acoustic transmitters. Although yaps is open source and transparent, the process from raw detections to final tracks has proved to be challenging for many potential users, effectively preventing most users from accessing the benefits of using yaps. Especially, the very important process of synchronizing the hydrophone arrays have proven to be an obstacle for many potential users. To make yaps more approachable to the wider fish tracking community, we have developed and added user-friendly functions assisting users in the complex process of synchronizing the data. Here, we introduce these functions and a six-step protocol intended to provide users with an example workflow that can be used as a template enabling users to apply yaps to their own data. Using example data collected by an array of Vemco VR2 hydrophones, the protocol walks the user through the entire process from raw data to final tracks. Example data sets and complete code for reproducing results are provided.
MODELING POST-KALA-AZAR DERMAL LEISHMANIASIS AS AN INFECTION RESERVOIR FOR VISCERAL LEISHMANIASIS

espanolLa leishmaniasis visceral (VL) es una enfermedad potencialmente mortal causada por el parasito protozoario Leishmania donovani. Esta enfermedad es un problema de salud para los muy pobres porque da lugar a miles de muertes e infecciones cada ano. Algunos paises, como la India y Bangladesh, han comenzado programas para reducir las ocurrencias de VL centrandose en el diagnostico precoz y el tratamiento completo de la VL. La leishmaniasis dermica post-kala-azar (PKDL) es una manifestacion cutanea de la leishmaniasis que puede ocurrir despues del tratamiento incompleto de la VL. El diagnostico y el tratamiento de PKDL son limitados en las regiones afectadas, y PKDL se ha identificado como un posible reservorio para la infeccion. Este estudio desarrolla un modelo matematico de la relacion entre el nivel de tratamiento de PKDL y las incidencias de VL durante un periodo determinado. Los resultados indican una relacion casi lineal entre las tasas de tratamiento de PKDL y la reduccion porcentual de incidencias de VL. Con los tratamientos actualmente disponibles y teniendo en cuenta los niveles alcanzables de tratamiento, el modelo predice que hasta 20% de los casos de VL podrian prevenirse mediante el tratamiento de nuevos casos PKDL. Tambien se tienen en cuenta iniciativas de tratamiento combinadas hipoteticas, como mosquiteros y pulverizacion de insecticidas. Los resultados sugieren que la poblacion de individuos con PKDL es sin duda un factor importante en la transmision de L. donovani, con el tratamiento de nuevos casos particularmente importantes. EnglishVisceral Leishmaniasis (VL) is a potentially fatal disease caused by the protozoan parasite Leishmania donovani. This disease is a health problem for the very poor because it results in thousands of deaths and illnesses every year. Some countries, such as India and Bangladesh, have started programs to reduce the occurrences of VL by focusing on early diagnosis and complete treatment of VL. Post-Kala-azar Dermal Leishmaniasis (PKDL) is a cutaneous manifestation of Leishmaniasis that can occur following the incomplete treatment of VL. Diagnosis and treatment of PKDL are limited in affected regions, and PKDL has been identified as a possible reservoir for infection. This study develops a mathematical model of the relationship between the level of PKDL treatment and the incidences of VL during a given period. The results indicate a nearly linear relationship between PKDL treatment rates and the percent reduction of VL incidences. With the current treatments available and considering achievable levels of treatment, the model predicts that up to 20% of VL cases could be prevented by treating new PKDL cases. Hypothetical combined treatment initiatives including bed nets and insecticide spraying are also considered. Results suggest that the population of individuals with PKDL is certainly a significant factor in the transmission of L. donovani infection, with treatment of new cases particularly important.
O C ] 6 J an 2 02 0 Stochastic Maximum Principle with Default

In this paper, we derive sufficient and necessary maximum principles for a stochastic optimal control problem where the system state is given by a controlled stochastic differential equation with default. We prove existence of a unique solution to the controlled default stochastic differential equation. Furthermore, we prove existence and uniqueness of solution to the adjoint backward stochastic differential equation which appears in connection to the maximum principles. Finally, we apply the maximum principles to solve a utility maximisation problem with logarithmic utility functions.
Development of a Method for Choosing Cloud Computing on the Platform of Paas for Servicing the State Agencies

In the scientific work is presented the development of a method of selecting cloud computing platforms for servicing government agencies, which in future will form the Digital Government according to the Message of the President of the Republic of Qazaqstan N. Nazarbayev to the people of Qazaqstan «Qazaqstan way 2050: Unified goal, common interests, common future». And also in the article are considered forecasts of growth and the development of cloud services in various countries, including Qazaqstan. Based on the results of research of company «Boston Consulting Group» (BCG), reflected in the article «Qazaqstan on the way to the digital economy», according to the level of digitalization the economy of Qazaqstan occupies the 50-th ranking of 85 governments and is in a group with emerging digital economy. The digital divide between the leading governments and the lagging countries is increasing from year to year; therefore, the article reflects one of the ways to develop the digitalization of Qazaqstan's economy. Descriptions and characteristics of various companies included in the international rating of Cloud100 are described as the most successful and competitive companies in the world on cloud technologies. All companies from this list are distributed as the top 20 companies for PaaS services. A criterion for selecting companies of cloud services is proposed, taking into account international and national ICT requirements. The web-portal (www.cloud.kz) was developed to assess the quality of cloud services from various companies of the world, which are working on cloud-based services. The analysis of the introduction of cloud services in Qazaqstan, and their advantages, and benefits for the public sector was made. For the cloud-based service of the module PaaS are selected the most optimal and suitable companies from the Cloud100 list. Ccs Concepts—Cloud computing → Programmable systems; Redundancy; Cloud • Services → Platform as a Service (PaaS)
Learning and memorisation amongst advanced piano students: a questionnaire survey

Professional musicians are often advised to use mental rehearsal techniques, including musical imagery, but to date there is little evidence regarding the extent to which these techniques are actually used, or indeed their relative efficacy. We conducted an online questionnaire with piano students at six UK conservatoires, designed to examine their conceptions and experiences of the process of learning and memorisation, and to identify which strategies were most commonly recommended and implemented. Results from 37 respondents showed that statements about conceptions of learning and memorisation did not always fit with self-reports of actual practice, and that although widely recommended, mental techniques were less likely to be implemented than physical rehearsal techniques. These findings suggest that while students may know about certain approaches and strategies they may not know how to implement them. Future research should investigate the relative efficacy of specific mental learning techniques involving deliberate uses of musical imagery and examine ways of teaching these techniques
OVERFUNDING IN CROWDFUNDING ON STARTNEXT AND KICKSTARTER PLATFORMS – ARE PRODUCT OFFERINGS MORE SUCCESSFUL THAN OTHER PROJECTS?

This study provides a first overview of the impact of offering a product besides other characteristics on project overfunding on two large platforms Startnext and Kickstarter based on 4,303 successfully overfunded European projects in the time between 2013 and 2015. In general, the level of overfunding in median equals to 10% on Startnext and 22% on Kickstarter, but varies to a high degree, depending on the industry category, as indicated by the mean of 55% on Startnext and 257% on Kickstarter. Results from regression analysis show that launching a product is significantly increasing the level of overfunding only for some categories of campaigns and in different ways on the two platforms. For Startnext and Kickstarter a comparably strong and medium effect of product offerings on the level of overfunding is only observable for projects from the Technology and Fashion category, respectively. Thus, the comparison reveals important differences which might be potentially interesting for investors, SMEs, founders and their advisors. Future research should focus on larger samples of successful and unsuccessful projects in order to provide more precise results.
Educational Video Game Design Based on Educational Playability: A Comprehensive and Integrated Literature Review

Design techniques can have an important effect on how video games teach and players learn. The abilit y to harness these techniques in the design of education al video game can impact the motivation and engagement of pl aying and learning by creating more options for players t o connect with game content as well as to other players. This article focuses on the design phase of the game development process and highlights the role of some techniques that can be used to design a successful educational video game (guideli n s and design patterns). These techniques provide informat ion on good practice and form a basis for evaluating the e ducational video game quality, acting as useful tools for deve lopers to enhance video game playability. To this end, we hav e presented a set of guidelines and design patterns in order to provide an acceptable level of playability and, in this way, a better player experiences and learning achievement. KeywordsPlayability; Player Experience PX; Educational Video Game EVG; Guidelines; Design Pattern.
Searching for heterogeneous treatment effects using generalized random forest

One approach to estimate the treatment effect is the generalized random forest method of Athey et al. (2019). I apply this method on the dataset of Borcan et al. (2017) to investigate the possibility of additional heterogeneous effects. Borcan et al. (2017) estimated the effect of the anticorruption campaign on education in Romania. In the aftermath of an anticorruption campaign, mostly poor students were negatively impacted by the policy. In my research I take all available variables into account to access which variable has been mostly affected by the anticorruption campaign. I find that in addition to a significant heterogeneous effect for poor students there is also heterogeneous effects for the (expected) number of students taking the Baccalaureate exam, county’s trust score for justice and unemployment rate. Due to the additional heterogeneous findings, both policy makers and researchers should be cautious when using parametric estimation methods for policy inference as it might not capture the heterogeneous effects well enough. Erasmus University Rotterdam Erasmus School of Economics Author Jon Hao Liu 409933 Supervisor Dr. (Andrea) A. A. Naghi Second accessor Dr. (Andreas) A. Pick
Front Page News: The Effect of News Consumption on Financial Markets

This paper estimates the effect of attention to news on financial markets, using quasi-random variation in positioning of news articles on the Bloomberg terminal. I focus on a category of news articles, some of which are pinned to the prominent “front page” positions at the top of the news screen in a process independent of their content. This offers a natural experiment in positioning between the articles that are pinned and those that are not. The front page and non-front page articles are indistinguishable by either algorithmic analysis, or by the target audience of active finance professionals. I find that pinning a news article to the front page leads to 280% higher trading volumes and 180% larger price changes within the first ten minutes after publication. These articles also see a much stronger short-term price drift, with 21% higher continuation in returns at the five-minute level. The effect is strongest during the first 30-45 minutes after the news, and partially reverses over subsequent hours. A comparison against differential reactions following news articles of varying editorial importance indicates that news positioning plays an even stronger role in driving market activity than news importance.
Design and Implementation of IR System for Tigrigna Textual Documents

Nowadays, various amount of information’s are available on the internet. To search relevant documents from the internet development of information retrieval system or search engines is necessary. Therefore, this paper deals with development of Information Retrieval system for Tigrigna textual documents. It helps to find relevant documents from the internet, which are stored in Tigrigna language for the Tigrigna language users to satisfy their information need. The system includes two sub systems those are indexing and searching part. The indexing part is the process of organizing filtered Tigrigna documents using keywords extracted from the entire Tigrigna collection or corpus. It is an offline process carried out by the producers or authors world to speed up searching of information from the entire document as per users query. Searching is the process of scanning documents to find relevant documents that matches to the users query or information need. It is an online process mostly carried out by the users or readers world. Vector space model techniques was applied to implement this system. Vector space model is the most core information retrieval technique used to calculate similarity measure between the query and the documents finally it ranks the most relevant documents to the given query according their similarity score in descending order. According to this, the retrieval system was tested and the experimental results of the system in Tigrinya documents returned an encouraging and promising result. The system has registered, 70% precision and 84% Recall.
Static Sign Language Recognition Using Deep Learning

—A system was developed that will serve as a learning tool for starters in sign language that involves hand detection. This system is based on a skin-color modeling technique, i.e., explicit skin-color space thresholding. The skin-color range is predetermined that will extract pixels (hand) from non–pixels (background). The images were fed into the model called the Convolutional Neural Network (CNN) for classification of images. Keras was used for training of images. Provided with proper lighting condition and a uniform background, the system acquired an average testing accuracy of 93.67%, of which 90.04% was attributed to ASL alphabet recognition, 93.44% for number recognition and 97.52% for static word recognition, thus surpassing that of other related studies. The approach is used for fast computation and is done in real time.
Systemic Review: Sexual Dysfunction in Women with type 2 Diabetes Mellitus

Diabetes would not just have a high blood glucose level in the individual body, yet these days diabetes likewise goes with numerous other organic issues like hypertension, feeble the myocardial layer working, sexual broke, and so on. These are some real issue which is these days joined by diabetes to a person’s body. Guys are for the most part being determined to have the sexual broke issue, guys, as well as experience a sexual broke issue. As similarly we may see less clinical examinations, including sexual broke issues looked for the sort two diabetic ladies. The primary goal of this article is to illuminate the situation that females proceed with much trouble with regards to the sexual broke Complication that might be physiological or neurotic if there should arise an occurrence of sorting two diabetes in ladies. It chiefly involves the useful extent of females like sexual drive, excitement, vaginal grease, Orgasm and general fulfilment space. Talking about the treatmentaccess of the ailment in the analyti way for it, Diabetes essentially hinders the sexual execution of Diabetic Women. Determinants of sexual ability incorporate age and extent of diabetes.
Effect of khat on ovarian oxidative stress in female rats

Oxidative stress (OS) greatly influences the reproductive health in female mammalian animals. The study used femaleWistar rats weighing 200  10 g grouped and administered orally as, control groups (1ml CMC), (0.5 g/100ml carboxy methyl cellulose)) and Khat groups (1ml khat extract) (150mg/kg) each for 3 and 6 weeks. Ovaries from each group at the two experimental periods used for the determination of ovarian OS markers. Results showed significant decrease in superoxide dismutase (SOD) enzyme activities and nitric oxide (NO) levels and reduced glutathione/oxidized glutathione (GSH/GSSG) levels as well as significant increase in malondialdehyde (MDA) contents in khat groups after 3 and 6weeks of treatment as compared to their corresponding control values. Results overt that ovaries from rats subjected to khat extract were under OS due to the imbalance between ROS production and anti-oxidants.