Miracle-dz/UniFAR-FTUs huggingface dataset:
Patient Characteristics and Outcomes of Gastrointestinal Stromal Tumor Patients Undergoing Imatinib Plasma Level Testing

v List of Figures . ix List of Tables . xi List of Abbreviations . xii Chapter 1. Introduction and Background . 1 1.1 Overview of GIST . 1 1.2 KIT and KIT Receptor Activation . 3 1.3 Molecular Genetic Aberrations of KIT and PDGFRA in GIST.7 1.4 Prognostic Value of KIT Mutations in GIST . 12 1.5 Imatinib Mesylate.17 1.6 Imatinib in CML . 21 1.7 Imatinib in GIST.22 1.8 Therapeutic Drug Monitoring of Imatinib in GIST . 29 1.9 Pharmacokinetics of Imatinib . 35 1.10 Response Evaluation of GIST by CT.40 1.11 Specific Aims of the Study . 45
Policy recommendations for current relationship between electronic commerce and Mexican SMEs: Theoretical analysis under the vision based on the industry

The objective of this essay is to present a different approach on the Porter’s five forces model and to make the reader aware of the topic of industrial competence and e-commerce in Mexico. In this essay, the method used is the analytic descriptive. First, the current situation in which SMEs in Mexico are related to e-commerce is exposed, since this last one provides a significant opportunity for the improvement of business results for this class of companies. In addition, a review of the empirical literature is provided in which models that allow measuring the degree of adoption of e-commerce by SMEs are exposed, as well as to understand the behavior of these economic agents with the e-commerce worldwide as in territory Mexican. Finally, as a result, an analysis is carried out under the model of the Porter pyramid in relation to Mexican SMEs and e-commerce.
A high resolution multiple-receiver SS-BSAR system

A multiple-receiver space-surface synthetic aperture radar (MRSS-BSAR) system is brought forward to improve azimuth resolution in SS-BSAR. The system is composed of one moving spaceborne illuminator and multiple static receivers. The receivers are arranged along the transmitter's moving direction with equal intervals. The profile in azimuth resolution(AR) direction of the point spread function(PSF) of the MRSS-BSAR is derived and the performance is simulated by back-projection processor(BPP). The MRSS-BSAR is proved to be able to achieve high azimuth resolution and not sensitive to targets' positions.
Global Efforts of Tax Authorities and Tax Evasion Challenge

Individuals or entreprising entities have been levied taxes over centuries by a sovereign power. The resources were always necessary to fill in the state treasury, even deeply back to the era where they were not called taxes yet. Citizens require high quality of public services financed by the capital obtained from tax collection. Governments provide public services which companies in the market do not provide, because they are not economical for them, such as building Abstract
Software Obfuscation on a Theoretical Basis and Its Implementation

SUMMARY Software obfuscation is a promising approach to protect intellectual property rights and secret information of software in untrusted environments. Unfortunately previous software obfuscation techniques share a major drawback that they do not have a theoretical basis and thus it is unclear how eﬀective they are. Therefore we propose new software obfuscation techniques in this paper. The techniques are based on the diﬃculty of interprocedural analysis of software programs. The essence of our obfuscation techniques is a new complexity problem to precisely determine the address a function pointer points to in the presence of arrays of function pointers. We show that the problem is NP-hard and the fact provides a theoretical basis for our obfuscation techniques. Furthermore, we have already implemented a prototype tool that obfuscates C programs according to our proposed techniques and in this paper we describe the implementation and discuss the experiments results.
Maximizing Networking Capacity in Multi-Channel Multi-Radio Wireless Networks

向每个节点提供至少一台多信道的收音机为由同时通过不同收音机接口利用多重非重叠的隧道并且通过合适的隧道赋值减轻干扰提高网络能力提供一条有希望的大街。 然而，它相当正在质问有效地利用多重隧道或多重收音机最大化产量能力。 中国(NSFC ) 工程 61128005 的国家自然科学基础进行了在在协议干扰模型下面并且根本上的无线网络预付现状的多信道的多收音机(MC 先生) 最大化无线联网能力的全面算法理论上、队列理论上的研究。 在非常难的物理干扰模型下面，另外，这个工程在最大化网络能力上拿了起始的算法的研究，与或没有力量控制。 我们期望在这个工程开发的新技术和工具将在能力计划有宽应用程序，资源分配并且分享，并且为无线网络的协议设计，和愿望与先进特征在无线网络用作未来算法开发的基础，例如多输入多产量( MIMO )无线网络。
Communication, language and education: a look from the theories of complexity

This work presents a conceptual model on the relationship communication – education from the perspective of complexity theories, using communicative interaction as analysis unit. In the birth of complexity explanations, the concept of system is explained, and is understood as a set of elements and relationships among them that tend to stay organized and to generate new elements. From this point of view, the basic concepts in complexity theories –self-organization, non-linearity, and the relationships among the system and other subordinate and superordinate systems –emerge as an explanation to communicative interaction. These concepts explain three communicative interaction aspects in education: knowledge structures, teacher– student relationship and knowledge environments. The new findings on the framework given by the relationship complexity-education-communication shows that a perspective on development and integration in causal dynamics about communicative interaction is needed to explain the complexity inherent to educative reality. This new language should focus on a natural science-social science new synthesis.
Frequency dispersion in partially depleted SOI MOSFET output resistance

Floating body effect (FBE) in partially depleted SOI MOSFET has become the focus of research recently. So far, most researcher concentrated their study on switching type circuit operation. However, in order to quantify the impact of floating body on analog circuit, small signal characteristic in frequency domain should be investigated. This paper reports an enhancement of output resistance (R/sub out/) at high frequency in partially depleted devices. The effect is explained by the floating body potential fluctuation under the influence of hole accumulation in the neutral body and gate coupling. At high current level, self heating effect overrides FBE and decreases R/sub out/ at high frequency.
Removing physiological artifacts from the EEG data by algorithms based on differential entropy

A new form of the nonlinearity implemented in the ICA approach is presented in the paper. The proposed independent component analysis based on differential entropy can be used for elimination of physiological artifacts from electroencephalographic signals. For verification of the quality of separation of the EEG data, the PI index is proposed. The second measure of accuracy is the normalized kurtosis which can be used in analysis of the simulated EEG data. As it has been proved, the new sigmoid function used in the ICA approach can effectively separate the EEG data.
Discrete Differential Geometry of Thin Materials for Computational Mechanics

Instead of applying numerical methods directly to governing equations, another approach to computation is to discretize the geometric structure specific to the problem first, and then compute with the discrete geometry. This structure-respecting discrete-differential-geometric (DDG) approach often leads to new algorithms that more accurately track the physically behavior of the system with less computational effort. Thin objects, such as pieces of cloth, paper, sheet metal, freeform masonry, and steel-glass structures are particularly rich in geometric structure and so are well-suited for DDG. I show how understanding the geometry of time integration and contact leads to new algorithms, with strong correctness guarantees, for simulating thin elastic objects in contact; how the performance of these algorithms can be dramatically improved without harming the geometric structure, and thus the guarantees, of the original formulation; how the geometry of static equilibrium can be used to efficiently solve design problems related to masonry or glass buildings; and how discrete developable surfaces can be used to model thin sheets undergoing isometric deformation.
Diferencias en el ritmo circadiano del infarto de miocardio según su extensión electrocardiográfica

Fundamento y objetivo: Determinar la existencia de ritmo circadiano en la hora de inicio del infarto de miocardio (IM) segun su extension electrocardiografica Q/no Q. Pacientes y metodo: Estudio retrospectivo de una cohorte de pacientes del proyecto ARIAM que incluyo 54.249 IM. Se analizan variables generales del infarto (edad, sexo, cardiopatia isquemica previa, extension del infarto, localizacion, supervivencia al alta de la unidad de cuidados intensivos), factores de riesgo cardiovascular y tratamientos farmacologicos previos al episodio estudiado. Para verificar la presencia de ritmo circadiano se ha desarrollado un test simple de igualdad de series basado en el analisis cosinor de multiples sinusoides, utilizando 3 sinusoides de periodos de 24, 12 y 8 h. Resultados: La hora de inicio de los sintomas del infarto mostro ritmo circadiano (p < 0,0000) tanto en el IM Q como en el IM no Q. Los IM Q presentan un patron con un unico maximo de incidencia matinal y los no Q, un patron bimodal con doble pico de incidencia. La comparacion entre dichos patrones muestra diferencias significativas en su ajuste (p < 0,0000). Conclusiones: La hora de inicio del IM sigue un patron circadiano, que tambien se observa en los subgrupos analizados. Las diferencias entre los ritmos circadianos segun el tipo de IM (Q frente a no Q) podrian explicarse por el distinto mecanismo fisiopatologico de ambos subtipos de infarto. El modelo de analisis de cosinor ajustado con 3 componentes (periodos de 24, 12 y 8 h) muestra buena sensibilidad para la deteccion de ritmo circadiano.
Road traffic accidents and mortality in Russia: 1956-2014

This article presents for the first time an analysis of the continuous statistical data series on deaths from road accidents in Russia since 1956. The total number of deaths for 1956-2012 exceeded 1.4 million. The increase in mortality from traffic accidents started in the 1970s; since the beginning of the 1990s, the lag behind most developed countries has been growing. At 2012 mortality levels, about 85-95% of Russia’s deaths from road accidents were excessive compared with the number of deaths that would have occurred at age-specific mortality rates from this cause in selected European countries. Both the current characteristics of the general level of motorisation and the main indicators of traffic injuries, such as the number of deaths per 100 thousand persons, per 10 thousand vehicles or per number of kilometres traveled, show that in terms of transport development Russia lags 40-50 years behind Western countries. The article also examines the history of the inclusion of mortality from road accidents in the International Classification of Causes of Death (ICD) and the problems of reflecting this mortality in Russian mortality statistics. Age and sex-specific patterns and trends in Russian mortality from traffic accidents are analysed, as well as the differences in mortality for different categories of road users (e.g. drivers, passengers and pedestrians) for the longest period possible. International comparisons that allow for understanding the extent of Russian backwardness and seeing the long-term unsustainable trends in mortality from road accidents are presented. The author points out the necessity of further scientific research into road and transport safety problems and the development of effective safety improvement programmes in Russia aimed to overcome the lag.
Transient Receptor Potential Vanilloid 1 in animal tissues: An overview to highlight similarities and differences with human species

The purpose of this review is to give an overview of the identification and the characterization of Transient Receptor Potential Vanilloid 1 (TRPV1) in animal tissues. TRPV1 is a receptor belonging to the superfamily of Transient Receptor potential (TRP) and it was first identified in dorsal root ganglion in 1997. After, the scientific interest on this receptor increased, and nowadays it is possible to read a huge bibliography dealing with this receptor that is considered ubiquitarian. Actually, it was identified in the majority of animal and human tissues in physiological and pathological conditions. The involvement of TRPV1 receptor is considered as a key to understand aetiopathogenic mechanisms and to try to find a therapeutic treatment. In spite of the deep knowledge on TRPV1 molecular structure, more studies are required to better understand the cascade following its activation. For all the previous mentioned reasons, TRPV1 was investigated in species of interest of Veterinary Medicine and some of them are important animal models for human medicine, especially for oncology and analgesic therapeutic strategies.
氟罗沙星对禽败血霉形体（Mycoplasma gallisepticum）病的药效研究

体外抑菌试验测得氟罗沙星（Ｆｌｅｒｏｘａｃｉｎ）对禽败血霉形体（Ｍｙｃｏｐｌａｓｍａｇａｌｉｓｅｐｔｉｃｕｍ）的最小抑菌浓度（ＭＩＣ）为０．０１５ｍｇ／Ｌ。 体内药效试验表明，氟罗沙星以２５、５０、１００ｍｇ／Ｌ饮水给药和以５、１０、１５ｍｇ／ｋｇ肌注给药（１次／ｄ），连续用药５ｄ，对人工气囊接种禽败血霉形体培养液（０．２ｍＬ，约含１０８ｃｆｕ）的雏鸡，保护率均为１００％（３０／３０），而感染不给药组雏鸡存活率为９３．３％（２８／３０）；相对增重率分别为９０．８％、９１．５％、９２．３％和９１．５％、９１．８％、９２．９％，显著高于感染不给药组（７３．２％）；气囊损伤分分别为２．９３、２．６２、０．９３和１．８、１．１、１．０，而感染不给药组为６．５７，差异显著（Ｐ＜０．０５）；血清玻板凝集试验阳性率分别为２０％（２／１０）、１０％（１／１０）、０（０／１０）和３０％（３／１０）、１０％（１／１０）、１０％（１／１０），均极显著低于感染不给药组１００％（１０／１０）（Ｐ＜０．０１）。 氟罗沙星不同给药途径及不同剂量间药效差异不显著。
Free Movement, Equal Treatment and Workers' Rights: Can the European Union Solve its Trilemma of Fundamental Principles?

This article analyses the trilemma the EU is facing concerning three fundamental principles on which the Community rests: free movement of services and labour; non-discrimination and equal treatment, and the rights of association and industrial action. With rising cross-border flows of services and (posted) labour after the Eastward enlargement, the conflict between these rights has triggered industrial disputes and judicial strife. In the view of the European Court of Justice (ECJ), highlighted in the Laval Quartet, some principles are more fundamental than others. Tracing the ‘dual track’ along which European integration has evolved, whereby supranational market integration has been combined with national semi-sovereignty in industrial relations and social policies, our claim is that the supremacy of free movement over basic social rights implied by the ECJ judgments is leading Europe in a politically and socially unsustainable direction. To prevent erosion of the European Social Models and of popular support for European integration, the politicians have to reinsert themselves into the governance of the European project. A pertinent start would be to ensure that the rising mass of cross-border service workers in Europe become subject to the same rights and standards as their fellow workers in the emerging pan-European labour market.
Un exemple de médiaplanning multimédia

Comment allouer un budget media entre les grands medias et la Publicite Non Adressee (PNA ou ISA), telle est la question a laquelle tente de repondre cet article. Au-dela de la problematique de la PNA, il a egalement pour but de montrer que l'allocation des depenses medias peut se realiser sur des bases tangibles de performance pour les medias du hors media. Cet article redefinit, dans un premier temps, les concepts du media-planning a cette allocation : couverture, repetition, accumulation des contacts, CPM, beta. Ensuite, a partir de modelisations concretes sur des donnees media de Home*Scan de ACNielsen, l'analyse montre les apports de la PNA dans un mix media, apport en couverture, en memorisation, efficience de ce media en terme de cout.
tunA: Synchronised Music-Sharing on Handheld Devices

tunA is a mobile peer-to-peer application that allows users to share their music locally with others who happen to be in their physical proximity. Playback is synchronized on all tunA devices that are “tuned into” the same source. These handheld devices are connected via ad-hoc 802.11 wireless networks formed as they come into and out of range with each other. With tunA, music constitutes the primary focus around which new social connections can be made and existing ones maintained. The localised dimension of the application aims to enable the creation of links between the virtual world of digital communication and file exchange and the physical reality in which users are immersed every day. In this paper, we briefly describe the tunA technology and a user study that we undertook to analyze its potential impact within a specific target group.
Biological Pacemaker – Main Ideas and Optimization

Electronic pacemaker, since its invention over five decades ago, has saved numerous lives and improved the life quality of patients suffering from cardiac arrhythmias. However, it has its own limitations. Over the past decade, rapid progress in the molecular studies of cardiac ion channels and stem cell biology has led to efforts for creating a biological pacemaker to supplement the widely used electronic pacemaker. We focus on the development of the ideas for creating a working biological pacemaker. The gene-based and cell-based approaches to meet the requirements of a working biological pacemaker will be reviewed. The important roles of the hyperpolarization-activated cyclic, nucleotidemodulated (HCN) channels, the inward rectifier Kir2.1 potassium channels, and the gap junctions in the biological pacemaker system will be discussed. Finally, recent development of cell-based strategy and precautions for creation of an effective biological pacemaker superior to the electronic counterpart will also be discussed.
The Relative Effectiveness of Input and Output-oriented Tasks with Different Involvement Loads on the Receptive and Productive Vocabulary Knowledge of Iranian EFL Learners

Framed in a cognitive approach to task-supported L2 vocabulary learning, the present study used a pedagogical approach to investigate the relative effectiveness of tasks with different involvement loads on the vocabulary knowledge of Iranian EFL learners. The goal was to investigate the way that the construct of involvement load is related to the Input Hypothesis (Krashen, 1985) and the Output Hypothesis (Swain, 1996) to see whether the involvement load or input/output-orientation of tasks is the determining factor in task effectiveness. The participants were 127 university students from four General English classes at the Islamic Azad University, Mobarakeh Branch, who were assigned to four instructional groups. Contrary to the predictions of the Involvement Load Hypothesis (Laufer & Hulstijn, 2001), the results of the study indicated that involvement load is not the only determining factor in task effectiveness, but input/output-orientation of tasks is also a decisive parameter in task effectiveness. While Laufer and Hulstijn’s proposal is the first valuable step towards building a theory of vocabulary learning, the results of the study indicated that involvement index may well not function independently of the task type, i.e., input or output orientation of a word-focused task.
Marcação semântica de páginas web apoiada por parsers de dependências gramaticais

With the exponential growth of the information in the Web, it becomes increasingly necessary that access to information be not only fast, but efficient. The search for information by means of the occurrences of keywords is the method used by Web search engines. However, the search for information on the Web can be optimized using a semantic representation of the information that is being sought. The present work presents a tool for semantic annotation of Web pages written in Portuguese, supported by Dependency Parsers. This tool, named Marcador Semântico, has the ability to provide a semantic representation for a number of sentences ocurring in a text, and encode the semantic representation of these sentences in the markup language RDF/XML. This work also presents a web tool, added to the repository of online tools of the NLX group, the Faculty of Sciences, University of Lisbon. This tool, called LX Dep Parser, is a Grammatical Dependency Parser and aims at returning to the user a representation of grammatical dependencies among the words of the input sentence.
Los aneurismas de la aorta torácica y su enfoque terapéutico

SummaryT HE AORTIC ANEURYSMS AND THERAPEUTICMANAGEMENT The aorta was saw has a tube who transportblood from the heart to all the human economy,today we see the aorta like an specific organwho not only is design to transport the bloodand it is elements, the aorta also produce hor-mones and elements of the inflammatory re-sponds and control the systemic pressure. That’swhy the aorta has it specific illness. In the entireworld the pathology of the aorta is quite frequentwith the appearance of a lot of new cases andoccupies a predominant place in the generalmortality of countries like United States of Amer-ica, Japan or Brazil. This pathology needs theutilization of large amounts of economics, hu-man and structural resources. In Mexico do nothave the statistical information of the aortic ill-ness because it is few diagnosed, and wheninduce death it confusing to another diseases.In the present time with the new no invasive di-agnostic methods more approachable to thegeneral population this disease is easier to di-agnose. That is why he need to develop a multi-disciplinary specialize group who can make thediagnosed and do the specific treatment forthese disease. (Arch Cardiol Mex 2006; 76: S2, 124-133)
Template-based keyword spotting for user generated videos

i Thesis Certification . iii Acknowledgements . iv Table Of Contents . v List Of Figures . x List Of Tables . xv Chapter 1 Introduction . 1 1.1 Overview . 1 1.2 Thesis Outline . 3 1.3 Contributions . 4 1.4 Publications . 5 2 Chapter 2 Literature Review . 7 2.1 Introduction . 7 2.2 Definition of User Video Blog . 8 2.3 Analyzing User Tags . 8 2.4 Traditional Video Classification . 9 2.5 Analysing the Audio Track . 11 2.5. 1 Automatic Speech Recognition . 12 2.5. 2 Keyword Spotting . 13 2.5. 3 Template-based Systems . 16 2.6 Principles of Hidden Markov Model (HMM) . 17 2.6. 1 Definition of the Recognition problem in HMM . 18 2.6. 2 HMM Baum-Welch Training . 21 2.6. 3 Recognition using Viterbi Algorithm . 24 2.7 Template based Recognition using Dynamic Time Warping . 25 2.7. 1 The Problem of Scaling Variability in Template based Recognition . 25 2.7. 2 Principles of Dynamic Time Warping . 26 2.7. 3 Finding the Optimal Path in Dynamic Time Warping Algorithm . 27 2.7. 4 Speaker-Independent Template-based Recognition . 29 2.7. 5 Building Templates using DTW . 31
Using Spatial Analysis for Non-spatial Data

A method is disclosed for accurately and readily forming a continuous band of rubberized fabric having transversal reinforcing metal elements by butt-splicing wherein a first and second piece of rubberized fabric having transversal reinforcing metal elements are positioned such that the initial end of the second piece is a predetermined distance from the terminal end of the first piece on a common plane with the reinforcing metal cords running parallel to the ends of the pieces, butt-splicing the pieces, without overlapping, by mutually approaching the pieces, obtaining a uniform accumulation of the rubber of the rubberized fabric about the reinforcing cords as well as a local thickening of the latter at a zone symmetrically situated with respect to the contact surface of the ends and whose width is proportional to the pre-established distance wherein the pieces are bound by the operating parts of the splicing apparatus, releasing the pieces from the operating parts of the splicing apparatus and winding up the continuous band on a collecting drum. An apparatus for producing the continuous band is also disclosed where the operating parts have a base element and a movable ledger capable of locking the pieces of rubberized fabric on a common plane by a series of fingers.