Miracle-dz/UniFAR-FTUs huggingface dataset:
‘The debatable territory where geology and archaeology meet’: reassessing the early archaeobotanical work of Clement Reid and Arthur Lyell at Roman Silchester

The first large-scale archaeobotanical study in Britain, conducted from 1899 to 1909 by Clement Reid and Arthur Lyell at Silchester, provided the first evidence for the introduction of Roman plant foods to Britain, yet the findings have thus far remained unverified. This paper presents a reassessment of these archaeobotanical remains, now stored as part of the Silchester Collection in Reading Museum. The documentary evidence for the Silchester study is summarised, before the results are presented for over a 1000 plant remains including an assessment of preservation, identification and modern contamination. The dataset includes both evidence for the presence of nationally rare plant foods, such as medlar, and several archaeophytes. The methodologies and original interpretations of Reid and Lyell's study are reassessed in light of current archaeobotanical knowledge. Spatial and contextual patterns in the distribution of plant foods and ornamental taxa are also explored. Finally, the legacy of the study for the development of archaeobotany in the 20th century is evaluated.
Experiences of stigmatization play a role in mediating the impact of disease severity on quality of life in psoriasis patients

Summary Background Psoriasis may have a severe impact on patients' quality of life (QOL) in several ways, an impact mediated by the mental or physical difficulties they have to deal with during the course of the disease and the various treatment regimens. In addition, psoriatic patients often suffer from experiences of stigmatization (EOS) related to the disease.
Património e regeneração: transformações urbanas da área envolvente aos canais aquáticos da cidade de Aveiro

Os canais que atravessam o centro urbano de Aveiro são património, imagem de marca da cidade e únicos em Portugal. São identificados como elementos estruturais que condicionaram a forma urbana e a sua evolução. A presente pesquisa visa verificar: (a) se a evolução urbana suportada pela análise dicotómica entre morfologia e transformações urbanas considera os canais aquáticos ao longo dos dois últimos séculos como cenários relevantes para a sustentabilidade económico-social da cidade de Aveiro; (b) se a partir da forma urbana existente, as estratégias identificadas na cidade de Aveiro - a expansão, a densificação e a centralidade -, contribuem para a regeneração do espaço urbano. Para cumprir os objetivos traçados, a investigação pretende estruturar uma matriz de critérios de intervenção como principal ferramenta de análise de dados quantitativos e qualitativos, segundo um fio condutor que tem como foco principal desta investigação, a regeneração das áreas urbanas contíguas aos canais. The canals that run through the urban center are the heritage of this city, being the market image of the latter and they are absolutely unique in Portugal. They are identified as structural instruments that had conditioned the urban shape and its evolution. Based on these firstlings, the research aims to check: a) if the urban development supported by the dichotomous analysis between morphology and urban transformations, considers the aquatic canals relevant sceneries, through the last two centuries, relevant sceneries for the social support of the Aveiro city; b) if from the existing urban form, the strategies that identify the city of Aveiro – expansion, density and the main center -, they contribute for the regeneration of the urban space. In order to achieve the already stated objectives, the research pretends to structure a range of intervention perceptions as an analysis tool for a connecting junction for quantitative and qualitative datas, being the main focus of this research, the regeneration of urban areas adjacent to the canals.
Relationship between intraseasonal variations of air pollution and meteorological variables in Hong Kong

Intraseasonal variation is an important component in monsoon regions to which Hong Kong belongs. This study investigates the relationship between intraseasonal variations of air quality and precipitation, wind direction and wind speed in Hong Kong. The intraseasonal variations are depicted by fluctuations with period of 3–90 days. Air quality is represented using the air pollution index of 14 air quality monitoring stations. Meteorological variables, including precipitation, wind speed and wind direction, are measured at the Hong Kong Observatory. It is found that the relationship between intraseasonal variations of air pollution and meteorological factors displays a strong seasonal dependence. Comparison between 2010 and 2011 indicates that the intraseasonal relationship varies largely from year to year. While more precipitation tends to favour better air quality, the statistical relationship between intraseasonal precipitation and air quality variations is not necessarily robust. Although wind speed increase usually enhances the dispersion of air pollutants, leading to an improvement in air quality, the statistical relationship on intraseasonal variations is not robust in some seasons. While northerly is the dominant wind direction for air quality worsening in Hong Kong, severe air pollution can occur under other wind directions in some unusual situations. The complexity of the intraseasonal relationship indicates that the relative importance of different factors in Hong Kong air quality change varies from season to season and from year to year, and that the large-scale background change may modulate the roles of factors in air quality change.
LPS-induced IL-6, IL-8, VCAM-1, and ICAM-1 Expression in Human Lymphatic Endothelium

We have previously reported the TLR4 expression inhuman intestinal lymphatic vessels. In the study here, microarray analysis showed the expression of the TLR4, MD-2, CD14, MyD88, TIRAP, TRAM, IRAK1, and TRAF6 genes in cultured human neonatal dermal lymphatic microvascular endothelial cells (LEC). The microarray analysis also showed that LEC expressed genes of IL-6, IL-8, VCAM-1, and ICAM-1, and the real-time quantitative PCR analysis showed that mRNA production was increased by lipopolysaccharide (LPS). The LPS-induced IL-6, IL-8, VCAM-1, and ICAM-1 production in LEC was suppressed by the introduction of TLR4-specific small interfering RNA, and also by anti-TLR4, nobiletin, and CAPE pretreatment. These findings suggest that LEC has TLR4-mediated LPS recognition mechanisms that involve at least activation of NF-κB, resulting in increased expression of IL-6, IL-8, VCAM-1, and ICAM-1. Both the LPS effect on the gene expression and also the suppression by nobiletin and CAPE pre-treatment on the protein production were larger in IL-6 and in VCAM-1 than in IL-8 and in ICAM-1 in LEC. The signal transduction of NF-κB and AP-1-dependent pathway may be more critical for the expression of IL-6 and VCAM-1 than that of IL-8 and ICAM-1 in LEC.
Sexual abuse and psychiatric disorder in England: results from the 2007 Adult Psychiatric Morbidity Survey

Background Evidence is accumulating that child sexual abuse (CSA) is associated with many psychiatric disorders in adulthood. This paper uses the detailed information available from the 2007 Adult Psychiatric Morbidity Survey of England (APMS 2007) to quantify links between CSA and a range of psychiatric conditions. Method The prevalence of psychiatric disorder was established in a random sample of the English household population (n=7403), which also provided sociodemographic and experiential information. Results We analyzed six types of common mental disorder, alcohol abuse and drug abuse, and people who screened positively for post-traumatic stress disorder (PTSD) and eating disorders. All were strongly and highly significantly associated with CSA, particularly if non-consensual sexual intercourse was involved, for which odds ratios (ORs) ranged from 3.7 to 12.1. These disorders were also related to adult sexual abuse (ASA), although the likelihood of reverse causality is then increased. Revictimization in adulthood was common, and increased the association of CSA with disorder. For several disorders, the relative odds were higher in females but formal tests for moderation by gender were significant only for common mental disorders and only in relation to non-consensual sexual intercourse. The population attributable fraction (PAF) was higher in females in all cases. Conclusions The detailed and high-quality data in APMS 2007 provided important confirmation both of the strength of association of CSA with psychiatric disorder and of its relative non-specificity. Our results have major implications at the public health level and the individual level, in particular the need for better recognition and treatment of the sequelae of CSA.
COMMENTS ON “CLINICAL AND EEG CLASSIFICATION OF EPILEPSY”

Comments on ”Assessment of a clinical and electroencephalographic classification of epileptic patients in everyday neurological practice. A survey of 450 cases” by S. Lavy, A. Carmon and I. Yahr. The critical study of Dr. Lavy, Dr. Carmon and Dr. Yahr is excellent, and it is gratifying to me personally to the extent that it confirms the validity of the classification of the epilepsies which I proposed in 1968. If I nonetheless exercise my privilege as editor of Efiilefisia to publish these comments, it is because this classification is no longer mine. A year after the publication of the classification in Efiilefisia (Gastaut 1969, supplement volume 10, 14-22) it was amended by the 15 members of an International Commision appointed by the World Federation of Neurology, the World Society of Neurosurgery, the International Federation of Societies for Electroencephalography and Clinical Neurophysiology and the International League against Epilepsy. After this amendment the Classification was officially adopted and republished in Efiilefisia (1970, 11: 117-119). In the meantime it was adopted by the World Health Organization for its Classification of Diseases and for the Glossary of the Epilepsies, which is in press. It is because of the international nature of this Classification and of its ever wider application that I would like not only heartily to endorse certain of the conclusions of 1,avy and his collaborators, but also to enlarge on certain other aspects. I am of course entirely in agreement that the International Classification of the Epilepsies is the more useful and permits classification of more patients when the information on each patient is full, detailed and precise. I would however like to point out that Lavy and his colleagues include in their study only two of the six factors utilized in the classification: the clinical type of the seizure and the interictal EEG. It is true that these factors are those most ~
An Efficient Dynamic Data Replication for HDFS using Erasure Coding

The Hadoop Distributed File System (HDFS) component of Apache Hadoop helps in distributed storage of big data with a cluster of commodity hardware. HDFS ensures availability of data by replicating data to different nodes. However, the replication policy of HDFS does not consider the popularity of data. The popularity of the files tend to change over time. Hence, maintaining a fixed replication factor will affect the storage efficiency of HDFS. In this paper we propose an efficient dynamic data replication management system, which consider the popularity of files stored in HDFS before replication. This strategy dynamically classifies the files to hot data or cold data based on its popularity and increases the replica of hot data by applying erasure coding for cold data. The experiment results show that the proposed method effectively reduces the storage utilization up to 40% without affecting the availability and fault tolerance in HDFS. Keywords— Big Data, Hadoop Distributed File System, Dynamic data replication.
Ambient air pollution exposure and incident adult asthma in a nationwide cohort of U.S. women.

RATIONALE Limited prior data suggest an association between traffic-related air pollution and incident asthma in adults. No published studies assess the effect of long-term exposures to particulate matter less than 2.5 μm in diameter (PM2.5) on adult incident asthma. OBJECTIVES To estimate the association between ambient air pollution exposures (PM2.5 and nitrogen dioxide, NO2) and development of asthma and incident respiratory symptoms. METHODS The Sister Study is a U.S. cohort study of risk factors for breast cancer and other health outcomes (n = 50,884) in sisters of women with breast cancer (enrollment, 2003-2009). Annual average (2006) ambient PM2.5 and NO2 concentrations were estimated at participants' addresses, using a national land-use/kriging model incorporating roadway information. Outcomes at follow-up (2008-2012) included incident self-reported wheeze, chronic cough, and doctor-diagnosed asthma in women without baseline symptoms. MEASUREMENTS AND MAIN RESULTS Adjusted analyses included 254 incident cases of asthma, 1,023 of wheeze, and 1,559 of chronic cough. For an interquartile range (IQR) difference (3.6 μg/m(3)) in estimated PM2.5 exposure, the adjusted odds ratio (aOR) was 1.20 (95% confidence interval [CI] = 0.99-1.46, P = 0.063) for incident asthma and 1.14 (95% CI = 1.04-1.26, P = 0.008) for incident wheeze. For NO2, there was evidence for an association with incident wheeze (aOR = 1.08, 95% CI = 1.00-1.17, P = 0.048 per IQR of 5.8 ppb). Neither pollutant was significantly associated with incident cough (PM2.5: aOR = 0.95, 95% CI = 0.88-1.03, P = 0.194; NO2: aOR = 1.00, 95% CI = 0.93-1.07, P = 0.939). CONCLUSIONS Results suggest that PM2.5 exposure increases the risk of developing asthma and that PM2.5 and NO2 increase the risk of developing wheeze, the cardinal symptom of asthma, in adult women.
Preoperative Gabapentin for Acute Post‐thoracotomy Analgesia: A Randomized, Double‐Blinded, Active Placebo‐Controlled Study

Background: The role of preoperative gabapentin in postoperative pain management is not clear, particularly in patients receiving regional blockade. Patients undergoing thoracotomy benefit from epidural analgesia but still may experience significant postoperative pain. We examined the effect of preoperative gabapentin in thoracotomy patients.
Comorbidities and short-term prognosis in patients hospitalized for acute exacerbation of COPD: the EPOC en Servicios de medicina interna (ESMI) study.

BACKGROUND Comorbidities are frequent in patients hospitalized for COPD exacerbation, but little is known about their relation with short-term mortality and hospital readmissions. Our hypothesis is that the frequency and type of comorbidities impair the prognosis within 12 weeks after discharge. METHODS A longitudinal, observational, multicenter study of patients hospitalized for a COPD exacerbation with spirometric confirmation was performed. Comorbidity information was collected using the Charlson index and a questionnaire that included other common conditions not included in this index. Dyspnea, functional status, and previous hospitalization for COPD or other reasons among other variables were investigated. Information on mortality and readmissions for COPD or other causes was collected up to 3 months after discharge. RESULTS We studied 606 patients, 594 men (89.9%), with a mean (SD) age of 72.6 (9.9) years and a postbronchodilator FEV1 of 43.2% (21.2). The mean Charlson index score was 3.1 (2.0). On admission, 63.4% of patients had arterial hypertension, 35.8% diabetes mellitus, 32.8% chronic heart failure, 20.8% ischemic heart disease, 19.3% anemia, and 34% dyslipemia. Twenty-seven patients (4.5%) died within 3 months. The Charlson index was an independent predictor of mortality (P < .003; OR,1.23; 95% CI, 1.07-1.40), even after adjustment for age, FEV1, and functional status measured with the Katz index. Comorbidity was also related with the need for hospitalization from the ED, length of stay, and hospital readmissions for COPD or other causes. CONCLUSIONS Comorbidities are common in patients hospitalized for a COPD exacerbation, and they are related to short-term prognosis.
Haemolytic‐uraemic syndrome outbreak caused by Escherichia coli O111:H–: clinical outcomes

In South Australia in 1995, we treated 20 children with haemolytic‐uraemic syndrome associated with Escherichia coli 0111:H‐. The source of the outbreak was contaminated locally produced semi‐dry fermented sausage (mettwurst). One child died of multiple haemorrhagic cerebral infarcts. Eighteen children required renal dialysis (for a median of 14 days); 12 months after discharge five still had significant impairment of renal function. Other major complications included colonic necrosis (3), cerebral haemorrhage/infarction (3), convulsions (4), and glucose intolerance (2). Although E.coli 0111:H‐ has been associated with sporadic cases of haemolytic‐uraemic syndrome, this was the first large outbreak reported in Australia.
Improved Approximation Algorithms for Tree Alignment

Multiple sequence alignment is a task at the heart of much of current computational biology [4]. Several different objective functions have been proposed to formalize the task of multiple sequence alignment, but efficient algorithms are lacking in each case. Thus multiple sequence alignment is one of the most critical, essentially unsolved problems in computational biology. In this paper we consider one of the more compelling objective functions for multiple sequence alignment, formalized as the tree alignment problem. Previously in [15], a factor-of-two approximation method was developed for tree alignment, which ran in cubic time (as a function of the number of fixed length strings to be aligned), along with a polynomial time approximation scheme (PTAS) for the problem. However, the PTAS in [15] had a running time which made it impractical to reduce the error bound much below two for small size biological sequences (100 characters long).
Open Randomized Trial Comparing the Immunogenicity and Safety of a New Measles-Mumps-Rubella Vaccine and a Licensed Vaccine in 12- to 24-Month-Old Children

Background: A trivalent measles-mumps-rubella (MMR) vaccine (MMR Berna) has been developed with a new mumps component, BBM-18, to replace a previously licensed MMR vaccine containing the Rubini mumps strain. Previous studies showed Rubini to confer insufficient long term protection against mumps infection. This study compared the immunogenicity and safety of MMR Berna, which is produced entirely in human diploid cells, with those of the licensed vaccine M-M-RVax (Merck & Co.). Methods: We vaccinated 467 subjects, 12-24 months of age, in an open, randomized (1:1), phase II, multicenter study. Antibody titers were determined for each vaccine component with a plaque neutralization test (PNT) and a commercial enzyme-linked immunosorbent assay. Solicited local and systemic reactions were recorded in subject diaries for 6 weeks after vaccination. Results: Seroconversion rates 6 to 8 weeks after vaccination for measles and rubella were statistically comparable for the 2 vaccines. However, mumps seroconversion rates were highly assay dependent, with significant differences being measured with the enzyme-linked immunosorbent assay (Berna, 77.4%; Merck, 91.3%; P < 0.001) but not the PNT (Berna, 84.8%; Merck, 87.6%; P = 0.42). The overall rate of systemic reactions was lower in the MMR Berna group (36.8% versus 45.9%; P < 0.05), including a significantly lower rate of fever of >38°C (37.2% versus 51.8%; P < 0.01). Conclusions: MMR Berna was statistically noninferior to M-M-RVax with respect to seroconversion rates, and the BBM-18 strain elicited a level of functional antimumps antibodies comparable to the Jeryl Lynn strain, as measured with the PNT. Overall, MMR Berna was better tolerated than the comparison vaccine, particularly with respect to the frequency of fever.
Analysis of equine humoral immune responses to the transmembrane envelope glycoprotein (gp45) of equine infectious anemia virus

Defined segments of the transmembrane envelope glycoprotein (gp45) of equine infectious anemia virus were expressed as TrpLE fusion proteins and examined for their reactivity in Western immunoblots against a diverse panel of equine immune sera. The most immunogenic region of gp45 was localized to its amino terminus, positioned between the hydrophobic fusion and the transmembrane domains. A series of overlapping synthetic peptides were used in enzyme-linked immunosorbent assays to define an immunodominant epitope within this region. In contrast, the carboxy-terminal half of gp45 displayed both weak and variable immunoreactivity with equine immune sera.
Rigid Tree Automata With Isolation

Rigid Tree Automata (RTAs) are a strict super-class of Regular Tree Automata (TAs), additionally capable of recognizing certain nonlinear patterns such as { f ⟨ x,x ⟩ ∣ x ∈ X } . RTAs were developed for use in tree-automata-based model checking; we hope to use them as part of a static analysis system for a logic programming language. In developing that system, we noted that RTAs are not closed under Kleene-star or pre-concatenation with a regular language. We now introduce a strict super-class of RTA, called Isolating Rigid Tree Automata, which can accept rigid structures with arbitrarily many isolated rigid substructures, such as “lists of equal pairs,” by allowing rigidity to be conﬁned within subtrees. This class is Kleene-star and concatenation closed and retains many features of RTAs, including linear-time emptiness testing and NP-complete membership testing. However, it gives up closure under intersection.
Avaliação andrológica por pontos e teste da libido em curral de touros jovens da raça Braford

O objetivo do presente estudo foi realizar a avaliacao andrologica por pontos e determinar a eficiencia do teste da libido em curral, de touros jovens da raca Braford, criados no norte do estado do Parana. Trinta e seis touros, com media de 21 meses de idade, foram submetidos ao exame andrologico, a classificacao andrologica por pontos (CAP) e o teste da libido em curral por 15 minutos. Os touros foram classificados de forma individual, no final de cada cinco minutos de observacao e, depois, de forma acumulativa, considerando todos os eventos fisiologicos observados. Com relacao a CAP, os touros foram avaliados como muito bons. O escore da libido variou em funcao do tempo de observacao (P <0,05), porem, durante os tres periodos de observacao, os touros se mantiveram classificados como bons. Quando a classificacao foi atribuida aos touros de forma acumulativa, foi verificado aumento do escore da libido, sendo classificados ao final do periodo como muito bons. Durante o periodo de teste, as classes de comportamentos de pre copula e identificacao foram as que apresentaram maior frequencia, seguida das classes de outros comportamentos e comportamento de copula. Quando comparado a frequencia das classes de comportamentos entre os tres periodos de observacao, foi verificado diferenca (P <0,05) das classes de comportamentos nos primeiros cinco minutos, em relacao ao restante do periodo de observacao. Palavras-chave : Andrologia. CAP. Libido. Braford.