Miracle-dz/UniFAR-FTUs huggingface dataset:
Hybrid Cell Membrane-Camouflaged Nanoparticle: A Novel Multifunctional Biomimetic Drug Delivery Carrier for Cancer Therapy

Biomimetic nanotechnology through camouflaging synthetic nanoparticles with natural cell membranes, which bestows with immune evasion and superior targeting capacity, has been extensively applied in drug delivery systems (DDS) over the last decades. Theses biomimetic nanoparticles (NPs) not only reserve the physicochemical features of the synthetic vehicles but also inherit the cell membranes' intrinsic functionalities. Combined with these benefits, optimized nano-biomimetic DDS allow maximum delivery efficacy. Compared to erythrocyte/cancer single cell membrane, the hybrid cell membranes expressing CD47 membrane protein and self-recognition molecules, from erythrocytes and cancer cells, provides incredible features to the synthetic vehicles, such as immune evasion, long-term circulation, and homotypic targeting. In this review, we described the preparation strategies, the camouflaging mechanism, and the antitumor applications of hybrid cell membrane-camouflaged nanoparticles. Moreover, we discussed further modification of the hybrid cell membranes and the surface properties of fusion cellular membranes. Finally, we summarized the primary challenges and opportunities associated with these nanoparticles.
Continuous Spherical Crystallization of Albuterol Sulfate with Solvent Recycle System

Spherical crystallization enables the direct preparation of crystal agglomerates of active pharmaceutical ingredients (APIs) with improved crystal handling properties. The continuous spherical crystallization of albuterol sulfate as a model API was developed using a mixed-suspension, mixed-product removal (MSMPR) crystallizer. The application of a solvent recycling system for reuse of the antisolvent in the single-stage MSMPR crystallizer was also demonstrated. Spherical agglomerates of albuterol sulfate were obtained via antisolvent crystallization using the MSMPR crystallizer with water as the solvent and an ethyl acetate/emulsifier (Pluronic L-121) mixture as the antisolvent. Steady-state continuous spherical crystallization was rapidly achieved after 30 min, and a yield of >95% was obtained. The influence of process parameters such as the solvent/antisolvent ratio, emulsifier concentration, residence time, and reactor scale on the properties of the agglomerates formed during the crystallization proces.
A 21-to-41-GHz High-Gain Low Noise Amplifier With Triple-Coupled Technique for Multiband Wireless Applications

This brief presents a wideband millimeter-wave (mm-Wave) low noise amplifier (LNA) with a triple-coupled technique for multiband wireless applications. To enlarge the gain and reduce the supply voltage, a modified cascode topology exploiting a triple-coupled transformer is developed. Thanks to the transformer, the transconductance of the common-gate (CG) transistor of the cascode topology is also effectively boosted, and hence the gain is further increased. Furthermore, high-order networks, which are realized by combinations of <inline-formula> <tex-math notation="LaTeX">$\pi $ </tex-math></inline-formula>- and <italic>T/L</italic>-type structures or transformers, are employed to implement the input, inter-stage, and output impedance matchings. They significantly broaden the bandwidth of the circuit. The LNA is demonstrated using a commercial 65-nm CMOS process. The measurement results show that the circuit achieves a maximum gain of 28.5 dB and a 3-dB gain bandwidth of 20 GHz with 32-mW dc power consumption (<inline-formula> <tex-math notation="LaTeX">$P_{dc}$ </tex-math></inline-formula>). The measured noise figure (NF) and input 1-dB gain compression point (<inline-formula> <tex-math notation="LaTeX">$IP_{1dB}$ </tex-math></inline-formula>) are 2.7~3.2 dB and −24.6~−20.4 dBm, respectively, over the entire operating bandwidth.
EFL Readers’ Understanding of Protagonist, Temporal, and Spatial Links in Narrative: Evidence From Eye Tracking

There are 5 types (dimensions) of information links between sentences in narrative texts: protagonist, intentionality, causality, temporality, and spatiality. Unlike the first 3 dimensions, little is known about how students of English as a foreign language (EFL) understand temporality and spatiality during reading. This eye-tracking study explored whether and how Japanese EFL readers understand these intersentential links by differentiating their initial and late processes during reading. In the experiment, 39 Japanese university students read short narrative texts. The texts contained a target sentence (e.g., Patricia ordered a cup of coffee) that was either consistent or inconsistent with a preceding context sentence (e.g., She was a coffee lover or She did not like bitter drinks) in terms of the protagonist, temporality, and spatiality. Students’ eye movements during reading were recorded and analyzed. The results showed that the students did not understand the intersentential links of any dimensions in their initial processes but did understand protagonist links in their later processes (lookbacks). These findings suggest that EFL students’ intersentential comprehension of multiple dimensions is limited compared to that of first-language readers both in terms of the number of dimensions understood and in terms of the processes during reading. This paper discusses the implications of these findings for education and research.
SYNERGIC EFFECT OF ADDING OR COMBINING EITHER RAW OR EXTRACTED PHYTOGENIC FEED ADDITIVES WITH PREBIOTIC ON PRODUCTIVE AND PHYSIOLOGICAL TREATS OF GROWING NEW ZEALAND WHITE RABBITS

A total number of ninety mixed sex growing New Zealand White (NZW) rabbits at age of 5 weeks and weighting 532 g were assigned randomly into six treatment groups, three replicates per treatment and 5 rabbits/replicate to study the synergic effects of combining either turmeric (as raw single phytogenic source) or Biostrong®510 (as purified extracted mixed phytogenic source) with mannan oligosaccharides; MOS (as prebiotic) on rabbit productive and physiological performance. The experimental period lasted for 8 weeks. The treatments were fed basal diet as control (C), basal diet plus 0.3 % turmeric (TU), basal diet plus 0.05 % Bio-mos® (BM), basal diet plus 0.015 % Biostrong® 510 (BS), basal diet plus 0.05 % Bio-mos +0.3 % turmeric (BM+ TU) and basal diet plus 0.05% Bio-mos +0.015 % Biostrong (BM+ BS). The study included the evaluation of growth performance, carcass traits, microbial examination, haematological indices, blood constituents, meat quality, histopathological and economical efficiency. The results revealed thatincrease body weight and body weight gain among all supplementation. The groups fed diets supplemented with either BM+TU or BM+BS recorded significantly higher body weight and body weight gain compared with control. The body weight gain increased significantly for groups fed BM+TU or BM+BS by 12.90 and 12.23%, respectively over control. The feed conversion ratio (FCR) improved significantly among all feed additives compared to control. Combining BM+TU or BM+BS improve FCR by 20.26 and 17.10 %, respectively compared to control. Also, dressing and total edible part percentage significantly increased for rabbits fed BM+TU or BM+BSmore than control by 11.11 and 8.52 % for dressing % and 6.95 and 6.76 % for total edible part %, respectively. Significant decreased observed in malondialdehyde value in meat for treatments TU and BM+TU compared to control and significant increase in glutathione peroxidase activity in treatmentsBM and BM+TU compared to control. Significantly increment in meat protein and significant reduction in meat cholesterolwere observed among all treatments compared to control. The lowest meat cholesterol value recorded by BM+BS and TU treatments. All feed additives recorded significantly reduction in pathogenic bacteria and significantly increased in beneficial bacteria. The economic evaluation showed improvement in relative economic efficiency by combining BM with TU or BS and achieved 138% and 131%, respectively. Conclusively, all feed additives were significantly improvement the productive and physiological treats for growing New Zealand white rabbits. Adding BM+ TU or BM + BS to growing rabbit diets recorded significantly the best value of productive and physiological treats and the higher economic efficiency compared to control.
Curtailing Fake News Propagation with Psychographics

Fake news is a widespread and concerning phenomenon. The goal of this article is twofold. First, we argue that curtailing fake news is better pursued by identifying its propagators than by classifying its content. Second, to validate our conceptual argument, we develop a system for curtailing the propagation of fake news on social media by identifying users who are susceptible to believing and propagating it. We anchor our approach in the debate about the ontological nature of truth, the empirical challenges of classifying fake news content, as well as the psychological and social origins of believing fake news. Through interpreting our model using modern explainable machine learning, we deepen our theoretical understanding of why people believe and share fake news, extend the applicability of our system beyond its original context, and provide guidelines for mitigating fake news propagation.
Comparing Acute Aerobic vs. Resistance Exercise (CAARE) in young and older adults: Design and methods of a randomized acute exercise trial on the immune system

Background: It is well accepted that exercise has numerous health benefits, including reducing the risk of developing cardiometabolic diseases and supporting a healthy immune system. Although these benefits are widely recognized, variations in the exercise response still exist. The aim of this study is to explore the variations that may be partially explained by participant age, physical activity status, and/or mode of exercise. Methods: The CAARE (Comparing Acute Aerobic vs. Resistance Exercise) study is a randomized cross-over design trial. Participants are young (18-30 years) or older (55-75 years), and within each age group are either physically active or inactive. All participants complete two acute exercise sessions of similar intensity and duration: a resistance training bout and a treadmill exercise bout. Blood is collected before exercise (PRE), immediately after exercise (POST), and after one hour of recovery (RECOV). Fresh blood is used for flow cytometry analyses to phenotype immune cells. Serum is stored for future analyses. The primary outcome variables are monocyte and T-cell phenotype. Discussion: CAARE is the first study to compare the immune cell response to acute exercise when including age, physical activity status, and mode of exercise. Clinical trial registration: This research study was registered at clinicaltrials.gov NCT03794050 in January 4, 2019. https://clinicaltrials.gov/ct2/show/NCT03794050
RESONANCE IN THERMAL FLUXES THROUGH CANCER MEMBRANE

A BSTRACT . Cancer represents one of the most important issues of the biomedical re- searches, which involve also other sciences, such as mathematics, physics, chemistry, biology, and engineering. In particular, a new thermophysical approach has been suggested and experimentally proved in the analysis of the growth behaviour of cancer cells. In this communication we introduce a theoretical evidence of the resonant behaviour of the heat exchange of the living cell. Last we summarise also the experimental results in support to this theoretical approach.
The Curious Case Of “Lesch-Nyhan” Syndrome

The Curious Case Of “Lesch-Nyhan” Syndrome. ABSTRACT Lesch-Nyhan is a rare disorder related to X-linked recessive genes, which occurs exclusively in males. This happens due to mutation of Xq26 chromosome and deficiency of hypoxanthine guanine phosphoribosyl transferase (HGPRT) enzyme. LNS is characterised by classical triad of symptoms Hyperuricemia, Spectrum of neurological dysfunctions, cognitive and behavioural disturbances including self mutilation. The symptoms occurs due to increase accumulation of uric acid in the body fluids to dangerous levels. Here we present a case of 2-year old child admitted in department of paediatrics with self mutilation, increased uric acid levels, delayed milestones, renal failure. After investigations diagnosis of LNS was established through various examinations.
WIDEBAND LOW-PROFILE SIW CAVITY-BACKED BILATERAL SLOTS ANTENNA FOR X-BAND APPLICATION

In this article, a new approach has been demonstrated for the bandwidth enlargement of a substrate integrated waveguide (SIW) cavity-backed antenna. The proposed structure employs bilateral slots, instead of unilateral slots, which is a distinct approach, in contrast to traditional cavity antennas. The proposed antenna embodies SIW cavity with a height less than 0. 017λ0 and thus holds a low-profile planar geometry, while retaining lower losses and light weight. The non-resonant slot, at the bottom plate, produces two-hybrid modes (odd TE210 and even TE210). The quality factor (Q) of these hybrid modes is greatly reduced by loading the resonant slot cut at the top metallic plate of the SIW cavity which leads to achieving a wideband response. A sample is fabricated and investigated at X-band. It is shown that the experimental results are well-matched with the simulated ones. The measured impedance bandwidth of the proposed antenna is 860 MHz, (8.6%). Moreover, it renders a maximum gain of 6.56 dBi at 9.78 GHz and 6.75 dBi at 10.35 GHz, within the operating bandwidth. The cross-polarization radiation levels of maximum −26 dB and −28 dB are obtained at the corresponding resonant frequencies, respectively.
Research of Ferr-Resonance Oscillations at the Frequency of Subharmonics in Three-Phase Non-Linear Electric Circuits and Systems

It is known that the occurrence and existence of ferroresonant oscillations at the subharmonic frequency (SHC) in power transmission lines (TL) and in power supply systems is extremely undesirable, since they cause ferroresonant overvoltages at different frequencies. At the same time, there is a wide class of nonlinear electrical circuits, in which the excitation of autoparametric oscillations (AIC) at the frequency of the SHC forms the basis of frequency converting devices serving as secondary power sources. It is shown that three-phase nonlinear systems are in one way or another equivalent circuits for power transmission lines, the main elements of which are: longitudinal compensation capacitors, transverse compensation reactors, and transformers with a nonlinear characteristic. To study the regularities of the excitation and maintenance of SHC at a frequency in three-phase electro-ferromagnetic circuits (EFMC), theoretical and experimental studies of an equivalent model of a three-phase circuit with nonlinear inductance were carried out. For the analysis of the steady-state mode of the SHC at the frequency, the method of a small parameter (averaging) was applied. A shortened differential equation of motion for a three-phase nonlinear circuit is obtained. By solving them, the regions of existence of the SHC and the critical parameters of the chain were determined. The obtained results of theoretical research are confirmed by experimental studies.
Mortality Prediction Model for COVID-19, Pneumonia, and Mechanically Ventilated ICU Patients: A Retrospective Study

Background: The objective of this study was to develop and evaluate a machine learning-based algorithm which accurately predicts mortality in COVID-19, pneumonia, and mechanically ventilated patients. Methods: A retrospective study of 53,001 total ICU patients, including 9,166 patients with pneumonia and 25,895 mechanically ventilated patients, was performed on the MIMIC dataset. An additional retrospective analysis was performed on a community hospital dataset containing 114 patients positive for SARS-COV-2 by PCR test. The outcome of interest was in-hospital patient mortality. Findings: W hen trained and tested on the MIMIC dataset, the XGBoost predictor obtained AUROCs of 0.88, 0.86, 0.81, and 0.78 for mortality prediction on mechanically ventilated patients at 12-, 24-, 48-, and 72- hour windows, respectively, and AUROCs of 0.86, 0.82, 0.79, and 0.75 for mortality prediction on pneumonia patients at 12-, 24-, 48-, and 72- hour windows, respectively. The predictor outperformed the qSOFA risk score at all prediction windows. When tested on the community hospital dataset, the predictor obtained AUROCs of 0.934, 0.927, 0.916, and 0.916 for mortality prediction on COVID-19 PCR positive patients at 12-, 24-, 48-, and 72- hour windows, respectively, outperforming the qSOFA risk score at all prediction windows. Interpretation: This machine learning-based algorithm is a useful predictive tool for anticipating patient mortality at clinically useful windows of 12, 24, 48, and 72 hours in advance, and is capable of accurate mortality prediction for mechanically ventilated patients as well as those diagnosed with pneumonia and COVID-19. Trial Registration : This study has been registered on ClinicalTrials.gov under study number NCT 04358510. Funding Statement: N/A Declaration of Interests: All authors who have affiliations listed with Dascena (Oakland, California, USA) are employees or contractors of Dascena. All other authors declare no conflicts of interest Ethics Approval Statement: Studies performed on the de-identified data constitute non-human subject studies, and therefore, our study did not require Institutional Review Board approval.
Effect of Adding Flue Gas Desulphurization Gypsum on the Transformation and Fate of Nitrogen during Composting

ABSTRACT The objective of this study was to investigate the effect of adding flue gas desulphurization gypsum (FGDG) on the transformation and fate of nitrogen during co-composting of dairy manure and pressmud of a sugar refinery. The ammonia absorption of FGDG was investigated. The changes in compost temperature, pH, electrical conductivity (EC), moisture, organic matter, the C/N ratio, Kjeldahl N, NH4+-N, NO2−-N, NO3−-N were assessed. The addition of FGDG did not significantly affect compost temperature, pH, EC, moisture, and organic matter degradation. However, the addition of FGDG significantly increased the NH4+-N content in the compost during the thermophilic phase, and the NH4+-N maximal content in the compost with FGDG (CP+G) was 59.9% more than that in the compost without FGDG (CP–G). FGDG was thought to create the formation of (NH4)2SO4 and the cation exchange between NH4+ and Ca2+. The NO2−-N content in the CP+G peaked on day 15, and was not observed in the CP–G. In the final compost products, the NO3−-N concentration in the CP–G was more than that in the CP+G, which was 1451 (CP–G) and 1109 mg·kg−1 (CP+G) dry material. This might be due to the NO2− accumulation in the CP+G, which accelerated N loss in the form of N2O. There is a strong correlation between N2O emission and NO2−-N accumulation in the composting process. Compared with the original N content in the compost mixture, the N loss in CP–G and CP+G were 15.0 and 10.8%, respectively. These results revealed that NH4+-N conservation effect was improved during the thermophilic phase and the total N loss was mitigated by adding FGDG into composting materials. FGDG could be utilized as a potential amendment to conserve nitrogen during composting.
Clinical, Molecular and Epidemiological Characterization of the SARS-CoV2 Virus and the Coronavirus Disease 2019 (COVID-19): A Comprehensive Literature Review

Coronaviruses are an extensive family of viruses that can cause disease in both animals and humans. The current classification of coronaviruses recognizes 39 species in 27 subgenera that belong to the family Coronaviridae. From those, at least seven coronaviruses are known to cause respiratory infections in humans. Four of these viruses can cause common cold-like symptoms, while others that infect animals can evolve and become infectious to humans. Three recent examples of this viral jumps include SARS CoV, MERS-CoV and SARS CoV-2 virus. They are responsible for causing severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and the most recently discovered coronavirus disease during 2019 (COVID-19). COVID-19, a respiratory disease caused by the SARS-CoV-2 virus, was declared a pandemic by the World Health Organization (WHO) on 11 March 2020. The rapid spread of the disease has taken the scientific and medical community by surprise. Latest figures from 14 April 2020 show more than 2 million people had been infected with the virus, causing more than 120,000 deaths in over 210 countries worldwide. The large amount of information we receive every day concerning this new disease is so abundant and dynamic that medical staff, health authorities, academics and the media are not able to keep up with this new pandemic. In order to offer a clear insight of the extensive literature available, we have conducted a comprehensive literature review of the SARS CoV-2 Virus and the Coronavirus Diseases 2019 (COVID-19).
Synthesis and Gas Separation of Chabazite Zeolite Membranes

: Chabazite (CHA) zeolite membranes exhibit superior performances in light gas separations owing to the eight-membered ring channel structure with small pore size (0.38 nm), adjustable surface characteristics, and high material stability and preparation reproducibility, and have gradually become one of the hot spots of zeolite membrane research in recent years. This review article first introduces the basic characteristics, the two typical CHA zeolite membranes (SAPO-34 and SSZ-13 membranes), then compares the synthesis and preparation methods of CHA zeolite membranes ( in-situ synthesis, secondary growth synthesis, microwave heating methods) and analyzes their advantages and disadvantages in application status. The influences of their key synthesis conditions of the secondary growth as the mainstream synthesis method on the qualities of SSZ-13 and SAPO-34 membranes have been elaborated in detail, mainly including 1) the seeding conditions, such as carrier type, seeding crystal and seeding approach; 2) the hydrothermal synthesis conditions, such as crystallization time and temperature, water content, silica-to-alumina ratio, structure directing agent, and cation type; 3) the calcination approaches, such as conventional calcination, staged calcination, and rapid heating treatments. After comparative analysis, the preferred synthesis conditions of the above two typical CHA zeolite membranes are proposed. Furthermore, the modulation of membrane surface chemistry is discussed for the enhancement in gas separation, such as silica-to-alumina ratio adjustment, ion exchange, heteroatom substitution, amino-group functionalization, and surface modification. The detailed characteristics of gas separation in various gas mixture systems and the permeation properties of different single gases on CHA zeolite membranes are analyzed and summarized as well. Finally, the future development of CHA zeolite membranes is prospected.
An Overview of the Properties and Biomedical Applications of Multi-Walled Carbon Nanotubes

The unique combination of electrical, mechanical and electrochemical properties offered by multi-walled carbon nanotubes (MWCNTs) has emerged as a potential element for their use in many kinds of applications including biomedical fields. In this article, the crystallographic structural and electrical properties of multi-walled carbon nanotubes (MWCNTs) have been discussed briefly. Finally the article concludes by focusing the key properties of MWCNTs which fostered their use in various biomedical applications, such as drug delivery, cancer treatment, gene therapy and diagnostics.