Miracle-dz/UniFAR-FTUs huggingface dataset:
A Study on Function-Expansion-Based Topology Optimization without Gray Area for Optimal Design of Photonic Devices

SUMMARY In this paper, we reformulate a sensitivity analysis method for function-expansion-based topology optimization method without using gray area. In the conventional approach based on function expan- sion method, permittivity distribution contains gray materials, which are intermediate materials between core and cladding ones, so as to let the permittivity di ﬀ erentiable with respect to design variables. Since this approach using gray area dose not express material boundary exactly, it is not desirable to apply this approach to design problems of strongly guiding waveguide devices, especially for plasmonic waveguides. In this study, we present function-expansion-method-based topology optimization without gray area. In this approach, use of gray area can be avoided by replacing the area integral of the derivative of the matrix with the line integral taking into acount the rate of boundary deviation with respect to design variables. We verify the validity of our approach through applying it to design problems of a T-branching power splitter and a mode order converter.
Stephanoprora uruguayense Holcman-Spector et Olague, 1989 [Digenea, Echinostomatidae] from Argentina, and comments on species of Stephanoprora from birds of the Neotropical Region

Abstract Adult specimens of Stephanoprora uruguayense Holcman-Spector et Olague, 1989 were obtained experimentally by infect-ing chicks with cysts from the gills of Galaxias maculatus (Jenyns, 1842) from Andean Patagonian lakes. Specimens of thisspecies were found in nature parasitising Larus dominicanus (Lichtenstein, 1823) in the same area. The species is redescribedand the validity of Stephanoprora spp. from birds of South America as well as the status of Stephanoprora manei Holcman-Spector et Olague, 1986 are discussed. Beaverostomum Gupta, 1963 is considered synonymous with Stephanoprora Odhner,1902. Stephanoprora dogieli Holcman-Spector et Olague, 1989, S. podicipei Etchegoin et Martorelli, 1997 and S. denticulata described by Torres et al . 1983, are synonymised with S. uruguayense . Acta Parasitologica, 2004, 49(4), 292–299; ISSN 1230-2821 Copyright © 2004 W. Stefanski Institute of Parasitology, PAS Key words Digenea, Echinostomatidae, Stephanoprora uruguayense , birds, Galaxias maculatus
Evaluation of acute colitis induced by dextran sulfate sodium in C57BL/6

Dextran sulfate sodium (DDS)-induced acute colitis in C57BL/6 mice is essential for several research aspects, but the inducing condition should be optimized with the purpose of different study. In this study, C57BL/6 mice drank water with 5 (w/v) % DSS dissolved for 7 days to induce acute colitis, which were evaluated from three aspects, including body weight change, colon length and histopathological changes. On day 8, the inflammation response to DSS treatment showed in the colon of C57BL/6 mouse. Compared with the control group, 5% DSS treatment decreased the weight of mice after drinking for 3 days, with Disease activity index (DAI) score corresponding to the pathological manifestations (p < 0.001). The colons were shorter significantly (p < 0.001) compared with control group. Partial colon of DSS-treated mice under H&E staining displayed severe inflammatory manifestations. In conclusion, this study constructed a successful acute colitis model, which can be a reference for others to do some studies related.
New pathway in rheumatic mitral valve disease: cytochrome P450 and glutathione S transferase isozyme expression

Abstract Objective Cytochrome P450 (CYP)1A1, glutathione S-transferase pi (GSTP1) and omega (GSTO1) isozymes were evaluated and compared in patients with the diagnosis of rheumatic mitral valve disease and ischemic mitral valve insufficiency to find out the relationship of the oxidative stress with rheumatic mitral valve disease. Materials and methods The control group consisted of patients operated on due to ischemic mitral valve insufficiency (group I, n:14) while study group consisted of the patients operated on with the diagnosis of rheumatic mitral valve disease (group II, n:29). Mitral valve materials were stained with hematoxylin and eosin. CYP1A1, GSTP1, and GSTO1 immunohistochemical markers were studied. Results 20.7% of GSTP1 isozyme protein expression was seen in the study group; however, no expression was detected in the control group. This finding was statistically significant in terms of GSTP1 isozyme. No statistically significant differences in the level of GSTO1 and CYP1A1 protein expression between the study and control groups were observed. Conclusion In this study, we found out that GSTP1 isozyme may be related to rheumatic mitral valve disease. A strategy that would help prevent oxidative stress in patients with rheumatic mitral valve disease can be a so valuable means to affect disease progression.
Comparing the Most Demanding Passages of Official Matches and Training Drills in Elite Roller Hockey

The aim of this research was to identify and compare the most demanding passages (MDP) in elite roller hockey in competition and in different training situations. Data were collected using WIMU PRO™ sensors with inertial micro-technology and ultra-wide band positioning. Eight professional roller hockey players from the Spanish First Division League (Ok Liga) were analysed during the 2017-2018 season. The MDP were studied using a rolling average method in which maximal values were calculated for three different time windows (1’, 2’ and 5’) in official matches and in four different training drills commonly used in the weekly team-training schedule: practice match (TRAINING MATCH), 4 vs. 4 in half court and one transition (4vs4+1T), 4 vs. 4 in half court and two transitions (4vs4+2T) and 3 vs. 2 wave transition drill (3vs2). The variable used for the comparison was the distance covered in high speed skating (HSS: >18 km · h–1; m · min–1) and only the maximum value of each player, drill and time window were stored for the study. The results show that training drills could not reproduce the maximum conditional effort that occurs in an official match in any time window. Moreover, all the situations and games analysed had higher levels of effort as the time of the window studied decreased. The analysis of shorter time windows could be a topic for future research. In conclusion, the findings of this study pave the way for future research into the identification and comparison of the most demanding scenarios in elite roller hockey that may help coaches to design training situations.
BRX modulates root growth sensitivity to ABA

Instituto de Biologia Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas-Universidad Politecnica de Valencia. Avd de los Naranjos, ES-46022 Valencia, Spain Phone: 34 963877860 Fax: 34 963877859 E-mail: prodriguez@ibmcp.upv. es Journal research area: signal transduction and hormone action Plant Physiology Preview. Published on February 6, 2009, as DOI:10.1104/pp.108. 133819
Processes of metastable-mineral formation in oxidation zones and mine waste

Abstract Oxidation zones and mine wastes are metal-rich, near-surface environments, natural and man-made critical zones of ore deposits, respectively. They contain a number of minerals which, despite their metastability, occur consistently and in abundance. Field studies, presented as examples in this work, show that metastable minerals form not only directly from aqueous solutions, but also from more complex precursors, such as nanoparticles, gels, X-ray amorphous solids, or clusters. Initial precipitation of metastable phases and their conversion to stable phases is described by the Ostwald's step rule. Thermodynamic data show that there is a tendency, but no rule, that structurally more complex phases are also thermodynamically more stable. The Ostwald's step rule could then state that the initial metastable phases are structurally simple and easily assembled from aqueous solutions, nanoparticles, gels, disordered solids, or clusters. The structural similarity of the precursor and the forming phase is a kinetic factor favouring the crystallisation of the new phase. Calculation of saturation indices for mine drainage solutions show that they are mostly supersaturated with respect to the stable phases and the aqueous concentrations are sufficient to precipitate metastable minerals. In our fieldwork, we often encounter gelatinous substances with copper, manganese or tungsten that slowly convert to metastable oxysalt minerals. Another possibility is the crystallisation of various metastable minerals from solid, homogeneous ‘resins’ that are X-ray amorphous. Minerals typical for near-surface environments may be stabilised by their surface energy at high specific surface areas. For example, ferrihydrite is often described as a metastable phase but can be shown to be stable with respect to nanosised hematite.
Oxidative Stress, Exercise and Aging

* Chemistry of Reactive Oxygen Species and Antioxidants (D Close & A E Hagerman) * Oxidative Stress in Plants and Animals (D Close & A E Hagerman) * The Exercise Continuum (R L Wiley) * Oxidative Stress and Muscle Size, Type, and Action (H M Alessio) * Oxidative Stress Across the Exercise Continuum (H M Alessio) * Oxidative Stress and Antioxidant Defense: Effects of Aging and Exercise (L L Ji) * Muscle, Oxidative Stress and Aging (J S Moylan et al.) * Age, Exercise, Antioxidants, and Cardioprotection (J Quindry & S Powers) * Genetic Expressions: Oxidative Stress, Exercise, and Aging (N B Schweitzer & H M Alessio)
Reconciling Carbon Pricing and Energy Policies in Developing Countries

The focus of the Report Reconciling Carbon pricing and Energy Policies in Developing Countries is how the objective of reducing emissions can be pursued alongside the priorities reflected in the energy policies of developing countries. The Report for Practitioners summarizes the Report’s main findings 4 and is split into three parts: part one examines interactions between climate and energy policies and related challenges and opportunities; some interactions are positive, some are negative. Part two focuses on the potential conflicts between carbon pricing on existing energy policy instruments, and the way to reconcile them through adjustments to either carbon pricing or energy policy instruments; part three outlines the options for ensuring the full integration of carbon and energy policies and instruments to accelerate low-carbon development; and Finally, the conclusion includes a practical Roadmap for climate and energy practitioners, which translates the Report’s main findings into to a set of actionable guiding principles. By providing a practical guidance to the practitioners, the Roadmap is expected to further facilitate the reconciliation of carbon pricing and energy policy and ultimately ensure their effective implementation.
A Review on Solid Lipid Nanoparticle of Artesunate And Mefloquine HCl For Malaria Treatment: A Novel Approach

Malaria may be quite common disease. Malaria may be a disease caused by a parasite. People suffering altogather age. In India around 2 Million of individuals suffer from Malaria. Sesquiterpine and Quinoline-methanol lactones are use to treat the malaria cause by the plasmodium falciparum parasite . Artesunate and Mefloquine HCl is highly effective and utilized in treatment of Malaria.Artesunate and Mefloquine HCl used for the great therapeutic effect and improve bio availability got to be prolong drug release. Solid Lipid Nanoparticles are solid colloidal particles starting from 1 to 100 nm in size, they contains micro molecular materials during which the active ingredients(drug or biologically active material) is dissolved, entrapped or encapsulated, or adsorbed, or attached.release of drug form nanoparticle are without dose dumping. Keyword: Malaria, Artesunate, Mefloquine HCl, Solid Lipid Nanoparticle drug delivery, Hot Homoginization technique.  INTRODUCTION INTRODUCTION TO MALARIA  Malaria may be a disease of the blood which will be fatal. It’s caused by the eukaryotic protists Plasmodium spp. The protists are spread to humans most ordinary through mosquitoes of the Anopheles  Malaria mainly caused by the one among protozoan parasites and it have mainly 4 types: 1. Plasmodium Falciparum 2. Plasmodium Vivax 3. Plasmodium Ovale 4. Plasmodium Malaria  Malaria Affect Over 40% population of the planet.  WHO Estimate That There Are 350-500 Million Cases Of Malaria World Wide.  In India 2 million Cases And 1000 Deaths in a year.
Dark triad and political cynicism as intermediate variables in the relationship between news frames and increased suicides

The research focuses on the main reasons of the increasing rates for youth suicide. The problem of the research underpins to identify the indirect effects of news frames in increasing the rates of suicide through the increasing of political cynicism and triad of darkness for youth which considers a supporting factors in suicide increasing and figure out the kind of the effect to the news frames on suicide; this research aims to find objective treatments for this problem and identify the negative effect of news frames in the increasing of political cynicism and the triad of darkness. The most important research findings are that the satellite stations and social media which owned by partisan sides are shaping the news negatively for certain quarters, therefore it has a destructive behavioral impact on the individual psychological; it is incumbent to be a psychological awareness for youth and developing a quick solution for the deteriorating situation.
An overview of ongoing point cloud compression standardization activities: video-based (V-PCC) and geometry-based (G-PCC)

Abstract This article presents an overview of the recent standardization activities for point cloud compression (PCC). A point cloud is a 3D data representation used in diverse applications associated with immersive media including virtual/augmented reality, immersive telepresence, autonomous driving and cultural heritage archival. The international standard body for media compression, also known as the Motion Picture Experts Group (MPEG), is planning to release in 2020 two PCC standard specifications: video-based PCC (V-CC) and geometry-based PCC (G-PCC). V-PCC and G-PCC will be part of the ISO/IEC 23090 series on the coded representation of immersive media content. In this paper, we provide a detailed description of both codec algorithms and their coding performances. Moreover, we will also discuss certain unique aspects of point cloud compression.
CHOROBA VON WILLEBRANDA U PSOW

supe-rior over clinical research methods. The essential re-sult of the low level of vWF is an increasing tenden-cy to spontaneous, prolonged bleeding from mucous membranes during teeth replacement, acute trauma or surgery. The key point is not to eliminate carriers of vWD when breeding, but conscious crossing the individuals after detailed genetic testing by foremost identifying the potential risk of this disease in dogs. The article is the comprehensive study about vWD in dogs with regard to genetic factors and clinical symp-toms, diagnostic methods and the treatment options.
Reflexivity and the use of the in-depth interview as a research method for family practices -based on research of socioeconomic strategies of action of families in Serbia

The paper has been conceived in the form of considerations on the process of research preparation and realization based on the in-depth interview as a research method. In the broader context of criticism levelled at qualitative research methods, all the phases related to data compilation and the phases of work done on the compiled material have been described and explained. An attempt has been made to use a specific example to point out all the principles which guide research and analysis, how researchers uses reflective research and the arguments in favor of certain choices, how systematicity is achieved, and to provide illustrations of the complexity and scientific relevance of research procedures in the creation of a highquality database. In addition, a discussion has been provided on the scientific basis of the entire process of database creation and the analytical procedures involved in working on it.
Mechanical Design in Organisms

This book deals with an interface between mechanical engineering and biology. Available for the first time in paperback, it reviews biological structural materials and systems and their mechanically important features and demonstrates that function at any particular level of biological integration is permitted and controlled by structure at lower levels of integration. Five chapters discuss the properties of materials in general and those of biomaterials in particular. The authors examine the design of skeletal elements and discuss animal and plant systems in terms of mechanical design. In a concluding chapter they investigate organisms in their environments and the insights gained from study of the mechanical aspects of their lives.
Collective/Abstract in Morphology

In morphology, the two labels ‘collective’ and ‘abstract’ have been used to refer to properties and categories relevant at different levels. The term collective is normally used in connection with number and plurality in reference to a plurality presented as a homogeneous group of entities. This can be relevant for inflectional morphology where it can be shown to flank markers for coding number in some languages. Moreover, a plurality intended as a homogeneous group of individuals can also be relevant for word-formation patterns where it usually expresses concrete or abstract sets of objects relating to the derivational base. The term abstract makes general reference to processes of nominalization from different source classes, especially verbs and adjectives. In the passage to the nominal domain, verbal properties like tense and argument structure are partially lost while new nominal properties are acquired. In particular, a number of semantic shifts are observed which turn the abstract noun into a concrete noun referring to the result, the place, etc. relating to the derivational base. Although the morphological processes covered by the two labels apparently depict different conceptual domains, there is in fact an area where they systematically overlap, namely with deverbal nouns denoting an abstract or concrete, iterated or habitual instantiation of the action referred to by the verbal base, which can be conceptualized as a collective noun.
Label-Free Identification of Early Stages of Breast Ductal Carcinoma via Multiphoton Microscopy

Breast cancer can be cured by early diagnosis. Appropriate and effective clinical treatment benefits from accurate pathological diagnosis. However, due to the lack of effective screening and diagnostic imaging methods, early stages of breast cancer often progress to malignant breast cancer. In this study, multiphoton microscopy (MPM) via two-photon excited fluorescence combined with second-harmonic generation was used for identifying the early stages of breast ductal carcinoma. The results showed differences in both cytological features and collagen distribution among normal breast tissue, atypical ductal hyperplasia, low-grade ductal carcinoma in situ, and high-grade ductal carcinoma in situ with microinvasion. Furthermore, three features extracted from the MPM images were used to describe differences in cytological features, collagen density, and basement membrane circumference in the early stages of breast ductal carcinoma. They revealed that MPM has the ability to identify early stages of breast ductal carcinoma label-free, which would contribute to the early diagnosis and treatment of breast cancer. This study may provide the groundwork for the further application of MPM in the clinic.
Sustainable provision of raw water based on the management of ecosystem services in small watersheds

The differentiated effects of the provision of environmental services in a watershed are due to the capacity of regularization of outflows in its mouth. In impacted areas, this environmental function is affected, and in some situations, it ceases to exist completely. This study characterized the soil and the production of sediments in anthropic watersheds, with the purpose of describing and evaluating the environmental services offered by a watershed undergoing anthropic transformation. The analyses show that the water flow in the remaining watersheds was preferably horizontal in the transmission zone, and these areas represent almost all areas. The values of hydraulic conductivity suggest that the infiltration decreases with soil depth; this fact is corroborated by the values of bulk density. The natural regions of water accumulation, the floodplains or outcrops zones, are small and do not have direct contact with the main floodplain present in the Guandu River Basin, making it impossible to recharge through other areas. Even so, water balance shows that the set of measures implemented ensured that the deficit water demand was supplied during the years of operation, even in times of water deficit. Likewise, the retention of solids in the settling tanks and in the drainage system prevented some 29,000 t of sediment from being carried between the years of 2012 and 2015.
Analysis of promoter hypermethylation of Runx3 gene in non-small cell lung carcinoma

Objective:To analyze the aberrant promoter hypermethylation of Runx3 gene in human non-small cell lung carcinoma(NSCLC). Methods: Methylation-specific PCR was performed to detect the promoter hypermethylation of Runx3 gene in 62 NSCLC tissue samples and 62 corresponding normal lung tissue samples.The effect of the aberrant methylation of Runx3 gene on the expression of Runx3 mRNA and protein was evaluated.The correlation between the aberrant methylation of Runx3 gene and the clinicopathological factors of NSCLC patients was also analyzed.Results: The promoter hypermethylation ratio of Runx3 gene in NSCLC tissues(48.4%) was significantly higher than that of the corresponding normal lung tissues(17.7%,P=0.000). The levels of p16 mRNA and protein expression in NSCLC tissues or normal lung tissues with complete or incomplete methylation were significantly lower than those with unmethylation.The aberrant methylation of Runx3 promoter was significantly correlated with tumor differentiation(P=0.041) and clinical stage(P=0.009),but not correlated with sex,age,smoking condition and tumor types of NSCLC patients(P=0.400,0.301,0.290 and 0.96,respectively). Conclusion: The aberrant methylation of Runx3 gene was associated with Runx3 downregulation,and detection of the aberrant methylation of Runx3 gene promoter in NSCLC would offer an effective method for the earlier auxiliary diagnosis of NSCLC.
The Physicality of Music Production: Investigating the Roles of Mindful Practice and Kinesthetic Learning

Music production and muscle movement are so interconnected that to begin the process of creating music, it is essential to consider the physicality behind the auditory perceptions. Playing-related injuries can arise from improper practice and failure to understand the physical movements underlying the music, and students and professional musicians alike can struggle with the failure of automatic muscle memory, particularly during a performance. This article outlines approaches to not only harnessing various aspects of kinesthetic learning for more effective playing but also to remaining attentive and actively in control of bodily movements during music-making. Encouraging students to maintain an awareness of their bodies and movements can be key to developing a healthier and more effective use of muscular systems in the production of music.