Miracle-dz/UniFAR-FTUs huggingface dataset:
Administration of testosterone results in reversible deterioration in Kennedy’s disease

Kennedy’s disease, or spinal and bulbar muscular atrophy (SBMA), is an X-linked neurodegenerative disease characterised by slowly progressive muscle weakness and atrophy of bulbar, facial and limb muscles accompanied by partial androgen insensitivity. The disease is caused by the expansion of a trinucleotide CAG repeat in the gene encoding the androgen receptor (AR). 1 There is no known treatment, although animal studies suggest that androgen deprivation may be of benefit.2 3 In this report, we describe a patient with SBMA who experienced significant worsening of his symptoms during treatment with testosterone, followed by complete reversal to pretreatment functioning on cessation of therapy. A now 67-year-old male first presented in 1995 with a 10 year history of difficulty walking. Examination revealed bilateral gynaecomastia and testicular atrophy. Cognitive examination was within normal limits. Examination of cranial nerves revealed fasciculation of the mentalis muscle and fasciculation and mild atrophy of the tongue. In the upper limbs, there was slight wasting of the abductor policis brevis, and absent brachioradialis and triceps reflexes bilaterally, while examination of the lower limbs revealed weakness of the illiopsoas and gastrocnemius muscles bilaterally (grade 4+ out of 5, and 4 out of 5, respectively), absent reflexes throughout and mild sensory loss in a stocking distribution. Nerve conduction studies were consistent with a predominantly motor axonal neuropathy, and electromyography showed widespread denervation. The clinical …
Advanced adaptability and profile management framework for the support of flexible mobile service provision

The long-term vision of beyond 3G wireless communications describes a mobile service provision environment dramatically different from that of today. Users are expected to raise their demands to a significantly higher level, towards the situation-aware provision of ubiquitous personalized multimedia services. From this perspective, the need is emerging to apply, in a systematic way, adaptability and reconfigurability concepts for service delivery in largely diverse contexts. Generic dynamically extensible adaptation mechanisms that can be employed in a wide variety of situations and are independent of the subject and criteria of adaptation is a significant step in this direction. Moreover, effective profile representation and management becomes an increasingly important issue. In the present article we introduce an advanced adaptability and profile management framework aiming to fulfill these requirements. The proposed system has been designed, implemented, and incorporated in a distributed middleware platform for next-generation mobile service provision.
Alterations of FOXO 1 protein expression during orthodontic tooth movement in rats

Objective: To study alternations in forkhead box, class O1 (FOXO1) protein expression in the periodontal tissue of rats during orthodontic tooth movement (OTM). Methods: A total of 60 Sprague-Dawley (SD) rats were randomly and evenly divided into six groups: an untreated control group and 5 groups treated with applied orthodontic force for 1, 3, 7, 10, and 14 days. The left maxillary first molar was used for experimental treatment, whereas the right side remained untreated as an internal control. OTM was established and tissue samples were collected. Hematoxylin-eosin (HE) staining was used to observe cell morphology; tartrate resistant acid phosphatase (TRAP) staining, to determine the number of osteoclasts on the alveolar pressure side; and immunohistochemical analysis, to analyze the expression of FOXO1. Results: The movement of the maxillary first molar initially increased with 1-3 days of orthodontic force, followed by a flattening between 3 and 7 days and then a continuous, rapid increase between 7 and 14 days. The number of osteoclasts initially increased, peaking at the 7th day after the start of orthodontic force, and then slowly decreased. The average optical density of FOXO1-positive immunostaining was significantly different in the pressure zone at 1, 3 and 7 days, and in the tension zone at 1, 3, 7, 10 and 14 days from that of the internal control (all P < 0.05). Conclusion: The alternations of FOXO1expression might participant in the periodontal tissue remodeling during the OTM.
Fault classification for power distribution systems via a combined wavelet-neural approach

This paper presents an integrated design of a fault classifier which uses a hybrid wavelet-artificial neural network (ANN) based approach. The data for the fault classifier is produced by PSCAD/EMTDC simulation program for 34.5 kV Sagmalcilar-Maltepe distribution system in Istanbul, Turkey. It is aimed to design a classifier capable of recognizing ten classes of three-phase distribution system faults. A database of line currents and line-to-ground voltages is built up including system faults at different fault inception angles and fault locations. The characteristic information over six-channel of current and voltage samples is extracted by the wavelet multiresolution analysis technique. Then, an ANN-based tool was employed for classification task. The main idea of this approach is to solve the complex fault (three-phase short-circuit) classification problem under various system and fault conditions. A self-organizing map, with Kohonen's learning algorithm and type-one learning vector quantization technique is implemented into this study. The performance of the wavelet-neural fault classifier is presented and the results are analyzed in the paper. It is shown that the technique correctly recognizes and discriminates the fault types and faulted phases with a high degree of accuracy in the simulated model distribution system.
Place de la colite microscopique parmi les colites chroniques non spécifiques diagnostiquées à Yaoundé, Cameroun

La colite microscopique est une atteinte inflammatoire de la muqueuse colique traduite cliniquement par une diarrhee chronique non sanguinolente et une coloscopie normale. C’est une affection encore mal connue dans notre milieu ou le diagnostic le plus pose en anatomo-pathologie est celui de colite chronique non specifique. Ce diagnostic embarrasse parfois les cliniciens quant au choix de la modalite de prise en charge la plus adaptee. Objectifs : L’objectif general de ce travail etait de rechercher la colite microscopique parmi les colites chroniques non specifiques diagnostiquees au Centre Pasteur du Cameroun (CPC). Les objectifs specifiques etaient les suivants: etudier les lesions elementaires des colites chroniques non specifiques; recenser parmi ces lesions elementaires celles qui sont conformes a la definition de colite microscopique ; discerner le type colite collagene du type colite lymphocytaire apres utilisation des colorations histopathologiques speciales sur le materiel biopsique de colite chronique non specifique; etablir le profil epidemiologique et morphologique de cette affection. Methodologie : L’etude est retrospective et analytique et s’est deroulee du 1 er janvier au 31 mars 2008. Elle portait sur les biopsies et les comptes rendus correspondants obtenus pendant 5 ans, du 1 er janvier 2003 au 31 decembre 2007 et pour lesquelles le diagnostic anatomopathologique de colite chronique non specifique a ete pose au CPC. Les blocs de paraffine correspondants ont ete recoupes . Pour chaque bloc 2 lames ont ete confectionnees : une coloree a l’hemateine-eosine (HE) et l’autre au Trichrome de Masson. Les lames ont ete reexaminees par un college de 3 pathologistes dont un exercant au CPC et les deux autres dans les hopitaux universitaires de Yaounde. Resultats : A partir des comptes rendus archives au laboratoire du CPC, 253 cas de biopsies coliques diagnostiques comme colites chroniques non specifiques ont ete repertories, dont 150 repondaient a la definition clinique de la colite microscopique (diarrhee chronique et coloscopie normale). 37 cas de colite microscopique ont ete diagnostiques dont 26 de type lymphocytaire et 11 de type collagene. Les femmes etaient les plus atteintes (23 cas) avec un sexe ratio de 1.6. L’âge des patients variait entre 11 et 79 ans. 8 avaient des antecedents medicamenteux (anti-inflammatoires non-steroidien – AINS: 5 cas ; ranitidine : 2 cas ; fer : 1 cas) et 4 une maladie auto immune associee (diabete 2 cas, rhumatisme 1 cas, hypothyroidie 1 cas). Conclusion: La colite microscopique est une entite a part entiere qui existe bien dans notre milieu Les pathologistes doivent porter une attention particuliere a la reconnaissance et la recherche de cette lesion. Les biopsies coliques doivent etre effectuees malgre une colonoscopie normale devant une presentation clinique de diarrhee chronique. Cette affection ne s’aurait donc se ranger dans le groupe de colites chroniques non specifiques.
SUPERNOVA CONSTRAINTS AND SYSTEMATIC UNCERTAINTIES FROM THE FIRST THREE YEARS OF THE SUPERNOVA LEGACY SURVEY

We combine high-redshift Type Ia supernovae from the first three years of the Supernova Legacy Survey (SNLS) with other supernova (SN) samples, primarily at lower redshifts, to form a high-quality joint sample of 472 SNe (123 low-z, 93 SDSS, 242 SNLS, and 14 Hubble Space Telescope). SN data alone require cosmic acceleration at >99.999% confidence, including systematic effects. For the dark energy equation of state parameter (assumed constant out to at least z = 1.4) in a flat universe, we find w = −0.91+0.16−0.20(stat)+0.07−0.14(sys) from SNe only, consistent with a cosmological constant. Our fits include a correction for the recently discovered relationship between host-galaxy mass and SN absolute brightness. We pay particular attention to systematic uncertainties, characterizing them using a systematic covariance matrix that incorporates the redshift dependence of these effects, as well as the shape–luminosity and color–luminosity relationships. Unlike previous work, we include the effects of systematic terms on the empirical light-curve models. The total systematic uncertainty is dominated by calibration terms. We describe how the systematic uncertainties can be reduced with soon to be available improved nearby and intermediate-redshift samples, particularly those calibrated onto USNO/SDSS-like systems.
Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination

SUMMARY Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium falciparum responsible for the majority of the disease burden and P. vivax being the geographically most widely distributed cause of malaria. Gametocytes are the sexual-stage parasites that infect Anopheles mosquitoes and mediate the onward transmission of the disease. Gametocytes are poorly studied despite this crucial role, but with a recent resurgence of interest in malaria elimination, the study of gametocytes is in vogue. This review highlights the current state of knowledge with regard to the development and longevity of P. falciparum and P. vivax gametocytes in the human host and the factors influencing their distribution within endemic populations. The evidence for immune responses, antimalarial drugs, and drug resistance influencing infectiousness to mosquitoes is reviewed. We discuss how the application of molecular techniques has led to the identification of submicroscopic gametocyte carriage and to a reassessment of the human infectious reservoir. These components are drawn together to show how control measures that aim to reduce malaria transmission, such as mass drug administration and a transmission-blocking vaccine, might better be deployed.
Venue Based Language Modeling for Expert Finding

Expert finding is hot topic discussed in co-author networks. Traditional language models only compares query terms with the documents of candidate for expert finding and ignores venues (conferences or journals) in which the paper is published. In this paper we propose novel influence language models which consider the importance of venues in which the papers of candidates are published. If the paper is published in a high level venue and another is published in a low level venue then these two papers should not have same weight-age for finding experts. The paper which is published in high level venue is more valuable than the paper which is published in low level venue. Experimental results show that our proposed models outperform the existing models.
Effect of stress and environmental temperature on adrenal function in Rana esculenta.

The effect of immobilization for 60 min on the adrenal activity of frogs (Rana esculenta) was studied by measuring corticosterone in plasma and corticosterone and catecholamines in adrenorenal homogenates. An increase in plasma corticosterone and in noradrenaline in the adrenorenal homogenate was observed after immobilization for 5 min and there was further increase after prolonged immobilization. However, there was no change throughout the period of immobilization in the corticosterone and adrenaline content of the adrenorenal homogenates. When frogs were exposed to various environmental temperatures the resting plasma corticosterone level did not change at temperatures below 20 \s=deg\C,but rose significantly at temperatures above 20 \s=deg\C.No increase in plasma corticosterone concentration occurred at 1 \s=deg\Cafter corticotrophin (ACTH) administration. At higher temperatures (up to 30 \s=deg\C)a significant correlation was found between plasma corticosterone levels after ACTH administration and environmental temperature. No further increase in plasma corticosterone took place at temperatures up to 40 \s=deg\C.The results indicate a rapid activation of both the interrenal and chromaffin components ofthe adrenal gland in Rana esculenta when subjected to this type of stress. Changes in plasma corticosterone levels resulting from changes in environmental temperature may be either an expression of specific changes in steroidogenesis of the adrenals, or of the entire metabolic activity of the organism.
The Language Experience Approach: Its Use with Young Hearing-Impaired Students

Language experience has proven to be an effective approach to reading for young children. The present three-month study describes the observed effects of using this method of instruction with kindergarten and first grade hearing-impaired students. The language experience approach encouraged growth in vocabulary, reading and writing skills as well as in self confidence and self esteem.
Mitochondrial ATP synthase is a target for TNBS‐induced protein carbonylation in XS‐106 dendritic cells

ROS are produced in dendritic cells (DCs) during antigen presentation in contact hypersensitivity (CHS). As a result, ROS cause a number of nonenzymatic protein modifications, including carbonylation, which is the most widely used marker of oxidative stress. 2,4,6‐Trinitrobenzene sulfonic acid (TNBS) is a well‐characterized contact allergen that results in the formation of ROS. However, proteins that are carbonylated in DCs in response to TNBS have not been identified. To study ROS‐dependent protein carbonylation in response to TNBS, we used the well‐established mouse DC line, XS‐106. We focused on the effects of TNBS on oxidation by examining selected oxidative markers. We identified TNBS‐induced ROS and myeloperoxidase (MPO) proteins and demonstrated that the increase in ROS resulted in IL‐12 production. The increase in oxidation was further confirmed by an oxidation‐dependent increase in protein modifications, such as carbonylation. In fact, TNBS strongly induced carbonylation of mitochondrial adenosine triphosphate (ATP) synthase in XS‐106 DCs, as determined by MALDI‐TOF analysis and 2‐D Western blotting. ROS production and protein carbonylation were confirmed in human monocyte‐derived DCs (Mo‐DCs). Furthermore, glutathione (GSH) decreased ROS and protein carbonylation in Mo‐DCs. Carbonylation of ATP synthase in DCs may contribute to the pathophysiology of CHS.
LEFT VENTRICLE ENDOCARDIUM SEGMENTATION FROM ULTRASOUND IMAGES USING PDAF WITH CANNY EDGE DETECTION

To characterize heart functionality automatic segmentation of the Left Ventricle endocardium from ultrasound (US) images is a essential step. There are several advantages involved in solving this problem in echocardiography. To access cardiac function of the heart in ultrasound images segmentation of the left ventricle (LV) is an important task. This paper presents a methodology for the segmentation of the LV in three-dimensional echo cardiographic images based on the probabilistic data association filter with canny edge detection. The proposed methodology begins with user input and it comprises the following feature hierarchical approaches such as edge detection in the vicinity of the surface, edge grouping to obtain potential LV surface patches, patch filtering using a shapePDAF framework (high-level features) and Canny edge detection. This method provides good performance accuracy than the state-of-the-art segmentation methodologies
A feature detector based on compressed sensing and wavelet transform for wideband cognitive radio

Detection of wideband communication signals is critical for cognitive radio (CR) as it enables secondary users to dynamically access the unoccupied bands. However, accurate and fast spectrum sensing is still a challenge in low signal to noise ratio (SNR) environment. To encounter this problem, a feature detector based on compressed sensing (CS) and wavelet transform (WT) (CS-WT feature detector) is proposed. Feature detector is chosen for its accuracy under low SNR, and CS is introduced to alleviate the sampling bottleneck of wideband sensing. Moreover, noise caused by the CS process is analyzed, and a traditional noise reduction method-two dimensional wavelet transform is utilized to cope with it by treating the spectral correlation function (SCF) as a grey image. It is verified by simulation that WT can effectively reduce the noise introduced by CS, and the proposed detector can achieve 90% detection probability under -10dB, making cyclostationary detection based on CS applicable.
A survey of Internet of Things in fire detection and fire industries

Internet of Things (IoT) provide a good chance to build powerful system in fire industry. The growing ubiquity of radio-frequency identification (RFID), wireless sensor network and mobile give fire area related applications by high leveraging level. This paper review about the current research, technologies and applications of IoT in flre related industries. This paper done a survey of identifying research trends and challenges in fire industries and summarizes systematically. The fire IoT aims to connect different things over the networks related with fire. Service Oriented Architecture is applied to support fire IoT. In that layers interact each other for monitoring fire and products. This paper functionally realizes some of the layer required for fire monitoring and industry. Sensing layer is functionally realized with WSN node with sensors, RFID tagged device and Video node for fire and product monitoring. All things such as sensor network, mobile network are connected together in the network layer. Service layer and interface layer are used to realize Mobile node data, WSN node data display and graph display for the fire related parameters.
Removal of Plaque and Stent Artifacts in Subtraction CT Angiography Using Nonrigid Registration and a Volume Penalty

Computed tomography angiography (CTA) is an established tool for vascular imaging. However, high-intense structures in the contrast image can seriously hamper luminal visualisation. This can be solved by subtraction CTA, where a native image is subtracted from the contrast image. However, patient and organ motion limit the application of this technique. Within this paper, a fully automated intensity-based nonrigid 3D registration algorithm for subtraction CT angiography is presented, using a penalty term to avoid volume change during registration. Visual and automated validation on four clinical datasets clearly show that the algorithm strongly reduces motion artifacts in subtraction CTA. Most artifacts disappear, also artifacts caused by minimal displacement of stents or calcified plaques, allowing a 2D and 3D artifact-free visualisation of the vessel lumen. This enables a quick overview of the whole vascular structure and opens the possibility to the visualisation of smaller vessels
Das mitochondriale Proteom von Rattus norvegicus in Abhängigkeit von Alter und Kalorienrestriktion

Die molekularen Mechanismen des Alternsprozesses eines jeden Organismus sind trotz jahrzehntelanger Forschung bis heute noch nicht erklarbar. Nach wie vor sind eher die Folgen des Alterns, wie Abnutzungs¬erscheinungen von Gelenken, Abbau von Muskel- und Knochensubstanz und das Auftreten von alterns-assozierten Erkrankungen wie Krebs, Diabetes und Demenz, bekannter als dessen Ursachen. Der Alternsprozess stellt einen langsam fortschreitenden nicht-reversiblen Vorgang dar, der auf zellularer Ebene eine Verminderung der Reaktionsfahigkeit auf zugefugten Stress bedingt und physiologisch einen Funktionsverlust von Geweben und Organen bis hin zum Tod nach sich zieht. Als erfolgversprechendste Intervention gegen das Altern und die damit assoziierten Erkrankungen wird derzeit die Kalorien¬restriktion (CR) diskutiert. Dabei handelt es sich um eine Diat, die unter Vermeidung einer Mangelernahrung die tagliche Kalorienzufuhr auf bis zu 50% des Normalwertes senkt. Fur zahlreiche Modellorganismen konnten ein lebensverlangernder Effekt sowie eine Verminderung des Auftretens von alterns-assoziierten Erkrankungen nachgewiesen werden. Das Ziel der vorliegenden Arbeit war es, die Auswirkungen des Alterns und der Kalorienrestriktion auf das mitochondriale Proteom und die Aktivitat von Proteinkomplexen der oxidativen Phosphorylierung (OxPhos) in den Geweben Herz, Hirn und Leber von Fischer-Ratten (Rattus norvegicus) zu untersuchen und damit Gemeinsamkeiten und gewebespezifische Unterschiede aufzudecken. Der Focus lag auf alterns- und CR-bedingten Veranderungen der OxPhos-Komplexe und deren Superkomplexe, die in der inneren Mitochondrienmembran lokalisiert sind. Durch Solubilisierung der mitochondrialen Membranproteine mit dem milden Detergens Digitonin konnten diese in einer blau-nativen Polyacrylamid-Gelelektrophorese (BN-PAGE) unter Beibehaltung der nativen Konformation und der Aktivitat aufgetrennt werden. Neben In-Gel-Aktivitatsmessungen der OxPhos-Komplexe I und IV in den angefertigten BN-Gelen wurde eine detaillierte Quantifizierung der Menge von einigen Untereinheiten der OxPhos-Komplexe I bis IV und der ATP-Synthase sowie anderen mitochondrialen Proteinen durch 2D-BN/SDS-Gelelektrophorese und anschliesender Farbung mit einem Fluoreszenzfarbstoff durchgefuhrt. Es wurden Ubereinstimmungen der alterns- und CR-bedingten Anderungen fur Herzmuskel, Hirn und Leber gefunden, allerdings konnten ebenso gewebe¬spezifische Unterschiede aufgedeckt werden. Fur das Herzgewebe wurden teils deutliche Unterschiede zwischen den beiden analysierten Mito¬chon¬drien¬spezies (subsarcolemmal und interfibrillar) bezuglich Proteinmengen und Aktivitaten detektiert.