Miracle-dz/UniFAR-FTUs huggingface dataset:
Regulation of growth–defense balance by the JASMONATE ZIM‐DOMAIN (JAZ)‐MYC transcriptional module

Summary The plant hormone jasmonate (JA) promotes the degradation of JASMONATE ZIM‐DOMAIN (JAZ) proteins to relieve repression on diverse transcription factors (TFs) that execute JA responses. However, little is known about how combinatorial complexity among JAZ–TF interactions maintains control over myriad aspects of growth, development, reproduction, and immunity. We used loss‐of‐function mutations to define epistatic interactions within the core JA signaling pathway and to investigate the contribution of MYC TFs to JA responses in Arabidopsis thaliana. Constitutive JA signaling in a jaz quintuple mutant (jazQ) was largely eliminated by mutations that block JA synthesis or perception. Comparison of jazQ and a jazQ myc2 myc3 myc4 octuple mutant validated known functions of MYC2/3/4 in root growth, chlorophyll degradation, and susceptibility to the pathogen Pseudomonas syringae. We found that MYC TFs also control both the enhanced resistance of jazQ leaves to insect herbivory and restricted leaf growth of jazQ. Epistatic transcriptional profiles mirrored these phenotypes and further showed that triterpenoid biosynthetic and glucosinolate catabolic genes are up‐regulated in jazQ independently of MYC TFs. Our study highlights the utility of genetic epistasis to unravel the complexities of JAZ–TF interactions and demonstrates that MYC TFs exert master control over a JAZ‐repressible transcriptional hierarchy that governs growth–defense balance.
Routing Mechanism for Secure, Distributed Discovery Services for Global Auto-ID Networks

Enterprises capture immense amounts of data in Auto-ID repositories as items travel along the supply chain. For collaboration among partners individual repositories need to be discoverable when they are not explicitly linked. At the same time confidential information including supply relationships needs to be protected. The task of identifying repositories by keeping the secrets of a supply chain is done by a Discovery Service. The discovery information can be spread over multiple nodes. The routing mechanism ensures that queries sent to any node within the Discovery Service hierarchy will be forwarded to all responsible nodes. By anonymizing the request and response propagation, the repositories and Discovery Service data nodes remain hidden as long as the request did not produce an authorized result set.
Amyloid‐Related Serum Protein (SAA) in Patients with Inherited Amyloidosis and Certain Viral Conditions

Amyloid‐related serum protein (SAA) was studied with a double immunodiffusion method. Only 2 of 21 patients with inherited systemic amyloidosis and lattice corneal dystrophy had elevated SAA levels in their sera. Several pseudo‐exfoliation patients had elevated levels of SAA, but it was not possible to differentiate an age‐related elevation of SAA from that associated with this disease. In addition, SAA was found in the sera of many groups of patients with acute viral infections, including 10 of 11 patients with measles and 7 of 11 persons vaccinated against rubella. Elevation of SAA protein appeared in the serum before the 6th day after the vaccination, had its peak value between days 6 and 12, but was absent already on the 20th day. In this relation the SAA protein appears to behave as an acute‐phase reactant.
Quality of life among female breast cancer patients in a university hospital in Malaysia.

Aims: To assess the Quality of Life (QOL) among female breast cancer patients in a university hospital in Malaysia. Study Design: The study was designed as a cross-sectional study. Place and Duration of Study: The study was conducted at the Surgery and Oncology Clinic in University Kebangsaan Malaysia Medical Centre (UKMMC) between 22nd May 2014 and 27th June 2014. Methodology: A total of 133 female breast cancer patients were selected by universal sampling, out of which 117 patients responded. The QOL was measured both by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) and breast cancer specific supplementary module (QLQ-BR23). Results: The global health status/QOL mean score was 67.81 (SD±18.92). Mean age of the respondent was 54 years (SD±18.39). Nearly half of the Malay breast cancer patients (45.6%) diagnosed at the stage of III & IV. In the functional scales, the highest mean score was observed for cognitive functioning 83.19 (SD±22.26); whereas emotional functioning had the lowest mean score 62.96 (SD±26.39). The respondents were satisfied with their body image with a mean score Original Research Article Edib and Kumarasamy; BJMMR, 6(5): 453-462, 2015; Article no.BJMMR. 2015.221 454 of 81.34 (SD±24.26) but greatly affected by sexual functioning with a mean score of 31.48 (SD±26.96). Most prevalent general symptoms reported in this study were fatigue, insomnia, pain, appetite loss and financial difficulties; and most prevalent breast cancer specific symptom was found upset by hair loss. Conclusion: Specific measures should be taken for the routine breast cancer screening, awareness and education programmes to promote early detection and diagnosis of the breast cancer. The planned rehabilitation protocol should be addressed by health care professionals to further improve the QOL among breast cancer patients.
Pilot study describing the use of pravastatin in pediatric renal transplant recipients

Abstract: Renal transplant (Tx) recipients frequently develop hypercholesterolemia. Pravastatin (P) has been shown to be effective in adult renal Tx recipients, not only in reducing serum cholesterol, but possibly also in decreasing graft rejection. However, there are no data on the use of P in children following renal transplantation. We conducted a retrospective case–control study evaluating the safety and efficacy of P (10–20 mg/day) in reducing hypercholesterolemia, when used pre‐emptively in the post‐Tx period in seven children, compared with an historical control (C) group of nine children who had not received P. The two groups were comparable with respect to their demographics and in their pretransplant serum cholesterol. Compared with the C group, the mean serum cholesterol in the P group was lower at 3 months (159 mg/dL vs. 225 mg/dL), 6 months (134 mg/dL vs. 200 mg/dL), 9 months (134 mg/dL vs. 209 mg/dL), and 12 months (125 mg/dL vs. 195 mg/dL) (p < 0.005 for all, Student's two‐tailed t‐test). At 1 month only 43% of the P group had hypercholesterolemia compared with 67% of the controls; by 12 months this difference was even more significant (0% in the P group vs. 45% in the C group). None of the treated patients developed any adverse reactions. This study demonstrates that the pre‐emptive use of P in pediatric renal Tx recipients appears to be effective in significantly reducing serum cholesterol. Whether this effect will translate into improved allograft and patient survival in the long term cannot be predicted at present and will require additional studies to evaluate.
Prosodic stress and topic detection in spoken sentences

The relationship between acoustic stress and the information content of words is investigated. On the one hand, the average acoustic stress is measured for each word throughout each utterance. On the other hand, an information retrieval (IR) index is calculated, based on the word frequency throughout the particular spoken sentence and throughout the collection of analysed spoken sentences. The scatter plots of the two measures (average acoustic stress on the y-axis and IR index on the x-axis) show higher values of average acoustic stress with increasing IR index of the word in the majority of the analysed utterances. A statistically more valid proof of such a relationship is derived from a histogram of the words with high average acoustic stress vs. the IR index. This confirms that a word with high average acoustic stress also has a high value of the IR index and, if we trust IR indexes, also a high information content.
Doxycycline hyclate: a review of properties, applications and analytical methods

The doxycycline hyclate is a broad-spectrum antibiotic oxytetracycline synthetic derivative used in several countries. It has been used to treat infectious diseases and as an additive in animal nutrition to facilitate growth. This drug is part of the list of medicines to the SUS (Unified Health System), a model of health care in Brazil, and it is free delivery in the public with a medical prescription. Thus, it is extremely important quality control of this medicine to be able to ensure their effectiveness and safety. Several existing analytical techniques, which offer flexible and broad-based methods of analysis and in some cases detection, have been discussed in this manuscript, focusing on bioanalytical and pharmaceutical quality control applications. This review will examine the published analytical methods reported for determination of doxycycline hyclate, discussing (a) separation methods such as thin layer chromatography and high performance liquid chromatography (HPLC) and (b) others such as, spectrophotometry and microbiological assay, from which it can be seen that HPLC methods have been used most extensively.
Intensity correction of phased‐array surface coil images

Phased‐array coils distribute the high signal‐to‐noise ratio (SNR) performance of their small component surface coils over the larger area covered by the entire array. The inhomogeneous sensitivity profiles of the component surface coils result in images with very high signal near the phased‐array and decreased signal far from the array. This paper presents a postprocessing algorithm for correcting these coil‐related intensity variations. The algorithm's performance was evaluated by correcting images of volunteers acquired with several different receive‐only phased‐array surface coils.
Bacterial leakage in coronally unsealed root canals obturated with 3 different techniques.

OBJECTIVE The purpose of this in vitro study was to evaluate the coronal leakage of microorganisms from saliva into root canals filled by 3 obturation techniques. STUDY DESIGN Obturated canals were mounted in an apparatus and then exposed to human saliva. The number of days required for the entire contamination of the root canal was recorded. Evaluation was carried out for 60 days. RESULTS Regardless of the technique used, a significant number of specimens were contaminated after 30 and 60 days. No significant differences were detected among the techniques (P >.05). CONCLUSIONS Results indicated that none of the techniques tested could predictably produce a coronal bacteria-tight seal of the root canal after direct saliva challenge.
Changes in Chad: the results of a KAP survey.

This, the 1st KAP survey to be conducted in Chad, surveyed 1222 women aged 12-49 at 6 health or social centers in N'Djamena in 1988, and summarized the information obtained from 21 focus groups. The sujbects were 25 years old on average; 94% were in union; 33% were in polygamous marriages, usually older women. 8% of Muslims and 17% of Christians were in a consensual union. Educational achievement was higher among younger women and Christians. 49% had income from the informal economy. Most valued the economic advantages of large families, which they believed resided in ancestors. Some noted the poulation pressures of urban living. 27% stated they were pregnant. Fertility was lower among Christians and those in monogamous marriages. Women of higher socioeconomic status had more children. Average age of 1st pregnancy was 16 years, lower in Muslims and uneducated women. Average weaning age was 17.8 months; average postpartum abstinence was 4.6 months, longer among Christians. The mean desired birth spacing interval was 26 months. 89% desired more children. The average ideal family size was 7.25, 8.6 for those 29 years old. The concept of birth planning was new to most, and ocnsidered a European idea contrary to African traditions. 31% could name a modern birth control method, increased to 58% with prompting, but only 3.2% had used one, and 1.3% were currently using. The cost of modern contraceptives is prohibitive for Chadians whose average GNP is $129. 56% expressed an interest on modern contraception for spacing, indicating a large unmet need.
Medical Center Farmers Markets: A Strategic Partner in the Patient-Centered Medical Home

Background The number of medical center–based farmers markets has increased in the past decade, but little is known about how such organizations contribute to the preventive health goals of the patient-centered medical home. Community Context In 2010, we started a seasonal farmers market at Penn State Hershey Medical Center to help support the institution’s commitment to the medical home. Methods We obtained descriptive data on the farmers market from hospital and market records and tracking information on the market’s Facebook and Twitter sites. We computed summary measures to characterize how the market has begun to meet the 6 standards of the 2011 National Committee for Quality Assurance’s report on the medical home. Outcome During the 2010 and 2011 seasons, 146 medical center volunteers from 40 departments formed 23 interprofessional teams that spent an average of 551 volunteer hours per season at the market, providing health screenings (n = 695) and speaking to customers (n = 636) about preventive health. Fifty-five nonmedical community health partners provided 208 hours of service at the market alongside medical center staff. Market programming contributed to 5 regional preventive health partnerships and created opportunities for interprofessional mentoring, student leadership, data management, development of social media skills, and grant-writing experience. The market contributed to all 6 medical home standards outlined by the National Committee for Quality Assurance. Interpretation Medical center markets can support medical home standards. With systematic tracking of the health effects and integration with electronic medical health records, markets hold potential to contribute to comprehensive patient-centered care.
Inhibition of class I histone deacetylases by romidepsin potently induces Epstein‐Barr virus lytic cycle and mediates enhanced cell death with ganciclovir

Pan‐histone deacetylase (HDAC) inhibitors, which inhibit 11 HDAC isoforms, are widely used to induce Epstein‐Barr virus (EBV) lytic cycle in EBV‐associated cancers in vitro and in clinical trials. Here, we hypothesized that inhibition of one or several specific HDAC isoforms by selective HDAC inhibitors could potently induce EBV lytic cycle in EBV‐associated malignancies such as nasopharyngeal carcinoma (NPC) and gastric carcinoma (GC). We found that inhibition of class I HDACs, particularly HDAC‐1, ‐2 and ‐3, was sufficient to induce EBV lytic cycle in NPC and GC cells in vitro and in vivo. Among a panel of selective HDAC inhibitors, the FDA‐approved HDAC inhibitor romidepsin was found to be the most potent lytic inducer, which could activate EBV lytic cycle at ∼0.5 to 5 nM (versus ∼800 nM achievable concentration in patients' plasma) in more than 75% of cells. Upregulation of p21WAF1, which is negatively regulated by class I HDACs, was observed before the induction of EBV lytic cycle. The upregulation of p21WAF1 and induction of lytic cycle were abrogated by a specific inhibitor of PKC‐δ but not the inhibitors of PI3K, MEK, p38 MAPK, JNK or ATM pathways. Interestingly, inhibition of HDAC‐1, −2 and −3 by romidepsin or shRNA knockdown could confer susceptibility of EBV‐positive epithelial cells to the treatment with ganciclovir (GCV). In conclusion, we demonstrated that inhibition of class I HDACs by romidepsin could potently induce EBV lytic cycle and mediate enhanced cell death with GCV, suggesting potential application of romidepsin for the treatment of EBV‐associated cancers.
A contactless power transfer system with capacitively coupled matrix pad

Capacitively Coupled Power Transfer (CCPT) technology has been proposed recently as an alternate contactless power transfer solution. This paper proposes a CCPT system with a matrix type of primary charging pad to maintain desired output voltage regardless of the positioning and alignment of the pickup. The capacitive coupling and system performance are analyzed in details, and a new algorithm is developed to control the proposed system. A prototype CCPT system using readily available aluminium sheets as the capacitive coupling pad is developed to prove the concept design. The system demonstrates that 0.7–2.5W output power can be obtained under coupling variation.
Identification of a sensitive period of prenatal cocaine exposure that alters the development of the anterior cingulate cortex.

Administration of cocaine to pregnant rabbits produces robust and long-lasting anatomical, neurochemical and behavioral alterations in their offspring. For example, exposure to cocaine following implantation [embryonic day (E) 8] through gestation (E29) produces increased length and decreased bundling of layer III and V pyramidal neuron dendrites, increased parvalbumin expression in the dendrites of interneurons, and increased GABA levels in the anterior cingulate cortex (ACC) and other dopamine-rich cortical areas. We have investigated the presence of a sensitive period of in utero exposure during specific developmental epochs prior to and during the onset of cortical development that might be capable of producing such effects. Cocaine (3 mg/kg i.v., twice daily) or saline was administered during embryonic days E16-E25 (onset and peak of corticogenesis), E8-E15 (prior to cortical plate formation), E8-E25 or E8-E29 as in earlier studies. Examination of the ACC in offspring exposed from E8 to E25 and from E16 to E25 were found to induce alterations in the development of pyramidal neurons and interneurons that are nearly identical to those induced by the complete exposure (E8-E29) paradigm. No alterations were observed following the E8-E15 cocaine exposure. These data suggest that exposure to cocaine during E16-E25, the time of peak corticogenesis, appearance of cortical monoamines and onset of D(1) dopamine receptor expression, is necessary and sufficient to produce long-term effects on the organization of excitatory pyramidal neurons and inhibitory interneurons in the ACC.
Bluefin Tuna (Thunnus thynnus) in Atlantic Canadian Waters: Biology, Status, Recovery Potential, and Measures for Mitigation Thon rouge (Thunnus thynnus) dans les eaux canadiennes de l'Atlantique : biologie, situation, potentiel de rétablissement et mesures aux fins d'atténuation

In May 2011, the Committee on the Status of Endangered Wildlife in Canada (COSEWIC) determined that Atlantic bluefin tuna (Thunnus thynnus) in the western Atlantic was Endangered. The reason for the designation is that the current abundance of spawning individuals is the lowest observed and the abundance of spawning fish has declined by 69% over the past 2.7 generations. COSEWIC concluded that the cause of the decline, overfishing, has not ceased and that it is not clearly reversible. A Recovery Potential Assessment (RPA) was held 13-15 July 2011 at the St. Andrews Biological Station, St. Andrews, NB. The purpose of the RPA was to provide information and scientific advice required to meet various requirements of the Species at Risk Act (SARA), including public consultations, decisions regarding the listing of western Atlantic bluefin tuna in Canadian waters under the Act, and developing a recovery strategy should the species be legally listed. In Canadian waters there is no evidence that range has been reduced and the proposed distribution target for recovery is to maintain habitat conditions allowing for a broad distribution in Canadian waters. Spawning stock biomass (SSB) shows an initial steep and steady decline from 1970 to the mid-1980s and relative stability since then, with indications of a possible slight increase in recent years. The proposed recovery target for abundance is to increase spawning stock biomass compared to 2012. The International Commission for the Conservation of Atlantic Tunas (ICCAT) estimated that the 2025 SSB would be equal to or larger than the 2012 SSB for catches of 2,250 mt or less. Maximum allowable harm was agreed to be the maximum removals by the fishery that would still result in the SSB in 2025 being greater than the SSB in 2012. The only documented human induced mortality to Atlantic bluefin tuna in Canadian waters is fishing; feasible mitigation measures to minimize the threat posed include a reduction or elimination of landings of western Atlantic bluefin tuna in directed fisheries or as a bycatch in other fisheries, and measures to increase the post-release survival of any Atlantic bluefin tuna released. Maritimes Region Bluefin Tuna in Atlantic Canadian Waters
Digital subtraction dark-lumen MR colonography for lesion detection - Initial experience

C. U. Herborn, W. M. Ajaj, T. C. Lauenstein, S. Massing, S. G. Ruehm Dept. of Diagnostic and Interventional Radiology, University Hospital Essen, Essen, Germany, University Hospital Essen, Essen, Germany INTRODUCTION Dark-lumen MR colonography combining a water enema with intravenous contrast administration is a rapidly evolving, minimally invasive method of evaluating the entire colon (1-2). Results of several preliminary series indicate that this technique has a high sensitivity for detection of colorectal cancer and significant polyp lesions as well as inflammatory disease of the bowel (3). Since bowel movements are depressed during the examination a digital subtraction technique comparable to vascular studies might be applicable and facilitate detection of regions with increased contrast uptake.
Resolution of severe psychogenic dysphagia with ECT in an elderly patient

ABSTRACT In this report we describe an 82-year female with a longstanding anxiety disorder who developed severe psychogenic dysphagia, leading to hospitalization due to failure to thrive. We describe for the first time the use of electroconvulsive therapy (ECT) to successfully manage a patient with pharmacological treatment resistant psychogenic dysphagia.