Miracle-dz/UniFAR-FTUs huggingface dataset:
The Epidemiology of Enteroviruses

International and local Scottish data illustrate the epidemiology of enteroviruses in recent years. Polioviruses still predominate as causes of serious paralytic disease, except where controlled by vaccination and require continuing surveillance. Aseptic meningitis is the commonest reported illness due to enterovirus infection, but notable clinical manifestations of certain types (particularly coxsackie group A) involve the skin and mucous membranes and the respiratory tract. Gastrointestinal disturbance has been reported in some echovirus infections, and cardiac disease is particularly associated with group B coxsackie virus infections. Although most enterovirus infections are silent or trivial in severity, the trend towards periodic epidemicity of different enteroviruses involving older age-groups may entail the emergence of new disease problems of which heart disease may be one example.
Face Distortion Aftereffects Evoked by Featureless First-Order Stimulus Configurations

After prolonged exposure to a distorted face with expanded or contracted inner features, a subsequently presented normal face appears distorted toward the opposite direction. This phenomenon, termed as face distortion aftereffect (FDAE), is thought to occur as a result of changes in the mechanisms involved in higher order visual processing. However, the extent to which FDAE is mediated by face-specific configural processing is less known. In the present study, we investigated whether similar aftereffects can be induced by stimuli lacking all the typical characteristics of a human face except for its first-order configural properties. We found a significant FDAE after adaptation to a stimulus consisting of three white dots arranged in a triangular fashion and placed in a gray oval. FDAEs occurred also when the adapting and test stimuli differed in size or when the contrast polarity of the adaptor image was changed. However, the inversion of the adapting image as well as the reduction of its contrast abolished the aftereffect entirely. Taken together, our results suggest that higher-level visual areas, which are involved in the processing of facial configurations, mediate the FDAE. Further, while adaptation seems to be largely invariant to contrast polarity, it appears sensitive to orientation and to lower level manipulations that affect the saliency of the inner features.
Substituição do uso da lenha e carvão vegetal por biocombustíveis sólidos no Baixo-Açu potiguar.

No Brasil, a falta de padronizacao nos metodos de coletas de dados e no uso de diferentes parâmetros de mensuracao visando a estimativa do consumo de energeticos madeireiros, dificulta o diagnostico mais preciso dessa demanda energetica regional e/ou especifica por setor demandante e consequentemente a comparacao de dados com outros levantamentos no tempo e no espaco geografico. Neste estudo procurou-se conciliar os dados oficiais do Balanco Energetico Nacional a pesquisa de campo empreendida no Baixo-Acu para tornar possivel uma estimativa bastante realista da dependencia da lenha e carvao vegetal dos consumidores desses combustiveis, em especial as fabricas de cerâmica vermelha da regiao. A conclusao e que, mesmo com a retirada insustentavel da mata nativa, a oferta de lenha comeca a dar sinais de esgotamento, deixando as empresas vulneraveis a precos cada vez mais elevados e ao risco de desabastecimento do combustivel - sem falar no agravamento da desertificacao na regiao. Uma das alternativas para mitigar este quadro, seria a instalacao de um cluster energetico na regiao que possui condicoes de oferta de varias materias primas, como a palha de carnauba, que sozinha pode ser ofertada para a producao de briquetes em aproximadamente 30.310 toneladas/ano.
Studies in the Childhood Psychoses I. Diagnostic Criteria and Classification

Until the last decade there was considerable confusion about the nosology of childhood psychoses. As Kanner (1958) has pointed out, certain psychodynamically orientated writers (Szurek, 1956; Beres, 1956) have eschewed the important operation of differential diagnosis. This has led to the notion of ‘equality of schizophrenias' (Darr and Worden, 1951) and thus to the idea of a single psychosis of childhood. The controversy over this approach has now waned in the face of empirical evidence from aetiological, phenomenological and follow-up studies, and many authors have stressed the importance of age of onset in their typologies or in their attempts at a more comprehensive classification (Kanner and Lesser, 1958; Mahler et al., 1949, 1952; Bender, 1947, 1959; Anthony, 1958, 1962, and Eisenberg, 1967). As this is also central to the present study it merits examination in greater detail.
Costimulation Blockade-Induced Cardiac Allograft Tolerance: Inhibition of T Cell Expansion and Accumulation of Intragraft cD4+Foxp3+ T Cells

Background. Previous studies have demonstrated that anti-CD40L or anti-B7 requires the presence of CD4+CD25+ regulatory T cells (Treg) to induce antigen specific hyporesponsiveness. Other tolerance strategies involving Treg have shown a dependency on interleukin (IL)-10. The objective of this study was to investigate the role of CD4+CD25+ Treg and IL-10 when treating transplant recipients with cytotoxic T lymphocyte-associated antigen (CTLA)-4 immunoglobulin (Ig), anti-CD40L, and anti-lymphocyte function-associated antigen (LFA)-1. Methods. Recombinase activating gene-deficient (Rag1−/−) mice were transplanted with BALB/c hearts and adoptively transferred with IL-10−/− CD4+ T cells, CD4+CD25− T cells or CD4+CD25−CD103− T cells and treated with costimulation blockade. Intragraft T cells from C57BL/6 recipients were analyzed for the expression of the Foxp3 protein after tolerance induction. Results. Mice reconstituted with IL-10−/− CD4+ T cells, CD4+CD25− T cells or CD4+CD25− CD103− T cells and treated with costimulation blockade accepted allografts permanently. Analysis of cells from recipient mice adoptively transferred with CD4+CD25− T cells contained a population of CD4lowCD25+ T cells 100 days after transplantation. Costimulation blockade partially prevented the homeostatic proliferation of CD4+CD25−CD103− T cells in Rag-1−/− recipients. Accepted allografts contained an elevated number of CD4+Foxp3+ T cells. Conclusions. These results indicate that T-cell derived IL-10 is not essential for induction of graft acceptance in mice treated with costimulation blockade, but that treatment limits T-cell expansion in the recipients. The results further indicate that tolerance is maintained by intragraft CD4+Foxp3+ T cells.
A nuclear circularity-based classifier for diagnostic distinction of desmoplastic from spindle cell melanoma in digitized histological images

Context: Distinction of spindle cell melanoma (SM) and desmoplastic melanoma (DM) is clinically important due to differences in metastatic rate and prognosis; however, histological distinction is not always straightforward. During a routine review of cases, we noted differences in nuclear circularity between SM and DM. Aim: The primary aim in our study was to determine whether these differences in nuclear circularity, when assessed using a basic ImageJ-based threshold extraction, can serve as a diagnostic classifier to distinguish DM from SM. Settings and Design: Our retrospective analysis of an established patient cohort (SM n = 9, DM n = 9) was employed to determine discriminatory power. Subjects and Methods: Regions of interest (total n = 108; 6 images per case) were selected from scanned H and E-stained histological sections, and nuclear circularity was extracted and quantified by computational image analysis using open source tools (plugins for ImageJ). Statistical Analysis: Using analysis of variance, t-tests, and Fisher′s exact tests, we compared extracted quantitative shape measures; statistical significance was defined as P < 0.05. Results: Classifying circularity values into four shape categories (spindled, elongated, oval, round) demonstrated significant differences in the spindled and round categories. Paradoxically, DM contained more spindled nuclei than SM (P = 0.011) and SM contained more round nuclei than DM (P = 0.026). Performance assessment using a combined shape-classification of the round and spindled fractions showed 88.9% accuracy and a Youden index of 0.77. Conclusions: Spindle cell melanoma and DM differ significantly in their nuclear morphology with respect to fractions of round and spindled nuclei. Our study demonstrates that quantifying nuclear circularity can be used as an adjunct diagnostic tool for distinction of DM and SM.
Behavioral Syndromes in Alzheimer's Disease

The Behavioral Syndromes Scale for Dementia (BSSD) is a new instrument that showed strong internal consistency and interrater reliability in an outpatient sample of 106 patients with probable Alzheimer's disease. Factor analysis provided support for a priori symptom groupings, particularly the syndromes of disinhibition and apathy-indifference. Dependency (87%), denial of illness (63%), and motor agitation (55%) were common, while sexual disinhibition (2.9%) and self-destructive behaviors (2.9%) were rare. Virtually all symptoms were predominantly minimal to mild in severity. Patients with longer illness duration were more apathetic. Disinhibited behaviors and apathy-indifference increased with greater severity of dementia. Catastrophic reactions, aggression, and agitation were associated with greater functional impairment. There was great heterogeneity in symptom presentation. In Alzheimer's disease, several behavioral changes might be direct manifestations of underlying brain pathology, rather than being solely secondary to cognitive impairment.
Cytochrome oxidase deficiency presenting as birth asphyxia

Hypoxic‐ischaemic encephalopathy (HIE) was diagnosed in an infant with acidosis. At 7 weeks of age further investigations revealed abnormal neuroimaging (CT and MRI scans) and a raised plasma and CSF lactate. A skeletal‐muscle biopsy at 2 months of age confirmed the diagnosis of cytochrome oxidase deficiency. The course of the patient's disorder has taken that of a static encephalopathy (cerebral palsy). Inborn disorders of the respiratory chain should be considered in the differential diagnosis of HIE.
Flooding Influences Ovipositional and Feeding Behavior of the Rice Water Weevil (Coleoptera: Curculionidae)

Abstract The rice water weevil, Lissorhoptrus oryzophilus Kuschel, is the most destructive insect pest of rice in the United States. As part of an effort to develop strategies to manage this pest, the ovipositional and feeding habits of L. oryzophilus on rice plants subjected to different flooding treatments were characterized in greenhouse studies. Presence and depth of flood had a direct influence on the ovipositional behavior of weevils in no-choice studies. More eggs were found in flooded plants than in unflooded plants. Moreover, plants flooded to a depth of 5.1 cm received more eggs than plants flooded to depths of 1.3 or 10.2 cm. Presence and depth of flood influenced both the proportion of females that oviposited in plants and the number of eggs laid by those females that did oviposit. In choice studies, female weevils showed a marked ovipositional preference for plants flooded to a depth of 10.2 cm over unflooded plants and plants flooded to a depth of 1.3 cm. In separate choice experiments, adult rice water weevils fed more on flooded plants than on unflooded plants. In a third set of experiments, flooded plants were taller and had higher concentrations of 10 of 13 plant nutrients than unflooded plants. Thus, flooding may influence rice water weevil behavior both directly, by acting as a stimulus for feeding or oviposition, and indirectly, by inducing changes in the suitability of rice plants for feeding or oviposition. These data suggest that it may be possible to manipulate populations of weevils in rice by changing water management practices.
Identification of a Novel Syntaxin- and Synaptobrevin/VAMP-binding Protein, SNAP-23, Expressed in Non-neuronal Tissues*

The specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP-25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are ubiquitously expressed proteins and are believed to be involved in vesicular transport in most (if not all) cells. However, SNAP-25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP-25 exists to facilitate transport vesicle/target membrane fusion in other tissues. Using the yeast two-hybrid system, we have identified a 23-kDa protein from human B lymphocytes (termed SNAP-23) that binds tightly to multiple syntaxins and synaptobrevins/VAMPs in vitro. SNAP-23 is 59% identical with SNAP-25. Unlike SNAP-25, SNAP-23 was expressed in all tissues examined. These findings suggest that SNAP-23 is an essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion in all mammalian cells.
Rennes (Ille-et-Vilaine). Les Portes Mordelaises

Installee il y a 2000 ans au confluent de l’Ille et de la Vilaine, Condate, devenue Civitas Riedonum au Bas-Empire, a ete dotee de murailles a partir de la fin du iiie s. La fortification antique a ete regulierement entretenue et reparee jusqu’au xve s. , periode a laquelle la ville prend un nouvel essor en devenant le lieu du sacre des ducs. C’est a cette periode que le duc Jean V fait edifier une nouvelle enceinte qui protege desormais la Ville Neuve a l’est de la Vieille Cite. Parallelement.
Molecular Regulation of MHC Class I Chain-Related Protein A Expression after HDAC-Inhibitor Treatment of Jurkat T Cells1

In this study, we characterize the molecular signal pathways that lead to MHC class I chain-related protein A (MICA) expression after histone deacetylase (HDAC)-inhibitor (HDAC-i) treatment of Jurkat T cells. Chelating calcium with BAPTA-AM or EGTA potently inhibited HDAC- and CMV-mediated MICA/B expression. It was further observed that endoplasmic reticulum calcium stores were depleted after HDAC treatment. NF-κB activity can be induced by HDAC treatment. However, nuclear translocation of NF-κB p65 was not observed after HDAC treatment of Jurkat T cells and even though we could effectively inhibit p65 expression by siRNA, it did not modify MICA/B expression. To identify important elements in MICA regulation, we made a promoter construct consisting of ∼3 kb of the proximal MICA promoter in front of GFP. Deletion analysis showed that a germinal center-box containing a putative Sp1 site from position −113 to −93 relative to the mRNA start site was important for HDAC and CMV-induced promoter activity. Sp1 was subsequently shown to be important, as targeted mutation of the Sp1 binding sequence or siRNA mediated down modulation of Sp1-inhibited MICA promoter activity and surface-expression.
Glycaemic control in hospitalised diabetic patients at the University Hospital Basel in 2002 and in 2005.

INTRODUCTION Hyperglycaemia has been shown to be detrimental in severely ill patients. Prospective randomized controlled trials in ICU patients demonstrated the benefit of near-normoglycaemia in reducing morbidity and mortality. Recommendations of professional societies (e.g., the American Diabetes Association) on glycaemic control in hospitalised patients have recently been published. It was therefore of interest to assess whether glycaemic control of diabetic subjects in our hospital adhered to these guidelines. No recent data are available on the glycaemic control of hospitalised diabetic patients in Switzerland. METHODS Medical records of 580 hospitalised patients with type 1 and type 2 diabetes (290 from 2002, 290 from 2005) were extracted from the internal data base of the University Hospital Basel. The selection was based on the charts of successive admissions each month of the year. From these 290 records, 100 records were from the medical and surgical wards, respectively, and 30 from the medical ICU (MICU), 30 from the surgical ICU (SICU) and 30 from the coronary care unit (CCU), respectively. Thereby, the quality of glycaemic control was assessed within and between the wards. RESULTS HbA1c of all diabetic patients with available measurements was 7.6 +/- 1.8% (mean +/- SD). HbA1c in medical wards was higher in 2005 than in 2002 (8.5 +/- 1.9% vs 7.5 +/- 2.8%; p = 0.014), and higher compared to surgical wards (8.5 +/- 1.9 % vs 6.7 +/- 1.1%; p <0.0001). On admission 60% of the plasma glucose concentrations (PGC) in medical and surgical wards were above the recommended limit of 8 mmol/l (10.8 +/- 7.5 mmol/l); in 63% of the measurements in the MICU, SICU and CCU the values were above 6.8 mmol/l. In 2005, PGC in medical wards on admission was higher than in surgical wards (13.5 +/- 9.9 vs 9.4 +/- 9.9 mmol/l, p <0.0001); in the MICU PGC was lower than in the SICU (9.7 +/- 1.5 vs 19.5 +/- 13.9 mmol/l; p <0.0001) and in the CCU (9.7 +/- 1.5 vs 14.1 +/- 12.1 mmol/l; p = 0.038). PGC decreased on day 4 compared to admission in the medical wards in 2005 (p = 0.024). In the other wards PGC in 2005 failed to decrease during hospitalisation. CONC:LUSION: Most diabetic patients admitted to the hospital remained distinctly hyperglycaemic during hospitalisation. This was the case even in intensive care units, where equipment and staff for improved glycaemic control were available and where strict glycaemic control has recently been demonstrated to result in decreased complications, mortality and length of stay.
The potential of sunitinib as a therapy in ovarian cancer

Introduction: Sunitinib malate (SU11248; Sutent®; Pfizer, Inc., New York) is a multi-kinase inhibitor currently approved for use in advanced renal cell carcinoma (RCC), imatinib-resistant/-intolerant gastrointestinal stromal tumours and progressive, well-differentiated pancreatic neuroendocrine tumours in patients with unresectable, locally advanced or metastatic disease. Areas covered: This article describes the mechanism of action and of the pharmacokinetics of sunitinib; further, it summarizes Phase I and II trials on the clinical efficacy, tolerability and safety of this agent in the setting of ovarian cancer (OC) treatment. Expert opinion: On the basis of the current literature, sunitinib has shown modest antitumour activity and acceptable toxicity. Studies investigating the impact of horizontal and vertical combinations should represent a priority of future research. Although clinical Phase II trials on the use of sunitinib in the treatment of OC demonstrated an acceptable profile of AEs, a greater comprehension of the toxicity of this compound is recommended.
Management of Diabetes-related Hypoglycemia

Iatrogenic hypoglycemia is the main factor limiting aggressive and optimal diabetes management. Rather than being an inevitable consequence of optimal glycemic control, however, hypoglycemia is avoidable and generally straightforward to manage when it occurs. Professional caregivers, patients, and their families are often fearful of hypoglycemia, even though most episodes are minor and easily self-treated. Understanding the factors contributing to hypoglycemia risk and how to minimize its occurrence is an essential part of diabetes care. Building on the physiologic fundamentals presented in the accompanying review, the incidence, mortality/morbidity, clinical symptoms, severity classification, and psychosocial impact of hypoglycemia are described here. Appropriate selection and titration of therapeutic agents, including insulin analogs with more predictable time-action profiles than human insulin formulations, can reduce hypoglycemia risk. Patient education about hypoglycemia prevention, including symptom recognition and necessity of rapid treatment, behavioral modification, and the importance of frequent blood glucose monitoring should accompany all therapeutic interventions.
Evidence for thin oceanic crust on the extinct Aegir Ridge, Norwegian Basin, NE Atlantic derived from satellite gravity inversion

Satellite gravity inversion incorporating a lithosphere thermal gravity correction has been used to map crustal thickness and lithosphere thinning factor for the NE Atlantic. Predicted oceanic crustal thicknesses in the Norwegian Basin are between 4 and 7 km on the extinct Aegir Ridge, increasing to 9 – 14 km at the margins, consistent with volcanic margin continental breakup at the end of the Paleocene. The observation (from gravity inversion and seismic refraction studies) of thin oceanic crust produced by the Aegir Ridge in the Oligocene may have implications for the temporal evolution of asthenosphere temperature under the NE Atlantic during the Tertiary. Thin Oligocene oceanic crust may imply cool (normal) asthenosphere temperatures during the Oligocene in contrast to elevated asthenosphere temperatures in the Paleocene and Miocene‐Recent as indicated by the formation of volcanic margins and Iceland respectively.
A NOVEL FINGERPRINT VERIFICATION USING RIDGE EDGE DETECTION TECHNIQUE

This paper proposes a method to verify the finger print of any individual based on ridge edge detection. MATLAB is used as the programming tool. The method detects the ridge endings and bifurcations of an individual finger print. The quality of the finger print image is enhanced by preprocessing for better performance. The verification, takes into account of the relative positions and alignment of the ridges. This results in a low false detection rate.
Examining User Technology Interaction: Toward a Sociotechnical Theory for Understanding User Adjustment to Mobile Technologies

Researchers from organization, management, and information systems areas have studied the impact of information technology (IT) on users in organizations for several decades. As a form of emerging technology, mobile computing has raised new research directions, as well as challenges for both computer scientists and social scientists. In this paper, we explore the issues of how well the emerging mobile computing technologies conform to past models and predictions that have been offered for explaining the impacts of IT. In particular, this paper identifies the general lack of attention to individual-level differences that may interact with contextual factors to shape organizational users’ reactions to this new computing paradigm. We thus propose that IS researchers consider a specific sociotechnical theory – Theory of Work Adjustment (TWA) – to investigate how individual users adjust to technology-initiated changes in work practices resulting from mobile technologies. By highlighting the insights offered by TWA, we believe that this model is useful for analyzing individual responses to the adoption of mobile computing technologies.
The Reasons for Wage Rigidity: Evidence From a Survey of Firms

A survey of 184 firms was conducted to investigate the reasons for wage rigidity. The strongest support was found for explanations based on adverse selection in quits and on the effect of wages on effort. In addition, survey respondents indicated that reducing turnover is an important explanation of wage rigidity for white-collar workers, and that implicit contracts are an important explanation for other workers. Respondents also believed that effort responds more strongly to wage decreases than to wage increases and that wage decreases have a greater impact on the effort of low-skilled workers than of high-skilled workers.