Miracle-dz/UniFAR-FTUs huggingface dataset:
Individualized Novel Therapies for Patients with Tumor Suppressor Genes BRCA1 and BRCA2 Mutated Epithelial Ovarian Cancer

Ovarian cancer is the leading cause of death in women with gynecological cancer, since a large proportion of patients are diagnosed at later stages of the disease. The incidence of ovarian cancer in the general population is 2%, but patients with germline mutations in the BRCA genes have a risk of developing ovarian cancer of up to 2050% with a cumula‐ tive risk of ovarian cancer at 70 years of age of 40% in BRCA1 and 18% in BRCA2 muta‐ tion carriers. Although it is a chemosensitive tumor, most of the patients after surgery and chemotherapy based on taxanes and platinum will relapse later in life. Due to the high risk of developing ovarian cancer in patients with BRCA germline mutations, new treatments rely increasingly on histological and molecular characteristics of the primary tumor, achieving greater selectivity and lower toxicity compared with standard cytotoxic agents. Poly (ADP-ribose) polymerase (PARPS) inhibitors are the first biologically active agents for patients with ovarian cancer with alterations in the DNA repair pathway, par‐ ticularly in the high-grade serous subtype of ovarian cancer. The results of clinical trials published so far mean that olaparib has been approved, pend‐ ing the results of the Phase III trials. The European Medicines Agency (EMA) adopted olaparib (lynparza ®) on the December 18, 2014, as a maintenance therapy after response to platinum-based chemotherapy in relapsed platinum-sensitive ovarian cancer patients with a BRCA mutation. By contrast, the Food and Drug Administration (FDA) approved olaparib on December 19, 2014, in patients with high-grade ovarian epithelial serous tu‐ mors and a BRCA mutation who have progressed during three or more lines of chemo‐ therapy. Olaparib is also used in primary fallopian tube and peritoneal cancers with BRCA mutations.
Germination response of Apocynum venetum seeds to temperature and water potential

Apocynum venetum (commonly known as luobuma or rafuma) is a shrub that is nature to Eurasia. It is economically important for sand fixation, forage production, honey production, medicine, fiber and fuel. Rapid and uniform seed germination is critical for successful crop establishment and vegetation restoration. The purpose of this study was to determine the germination responses of A. venetum seeds to temperature and water availability using hydrotime, thermal time and hydrothermal model analysis. S eed germination was relatively high for A. venetum from 25 °C to 30 °C. The base (T b ) , optimum (T o ) and ceiling temperatures (T c (50)) of A. venetum seed germination were 16.6, 27.0 and 45.9 °C, respectively. Values of base water potential (Ψ b (g) ) shifted to zero with increasing temperature, which was reflected in the greater effect of low Ψ on germination for temperatures above 30 °C. Hydrotime analysis suggested that T b may not be independent of Ψ, and Ψ b (g) may change as a function of temperature at temperatures below 30 °C. The interaction effects of Ψ and temperature reduced the ability of the hydrothermal time model to predict germination performance across temperature and Ψ conditions.
Testing Weak Exogeneity in Cointegrated System

This paper develops a limiting theory for Wald tests of weak exogeneity in error correction models (ECMs). It is well known that Wald statistics on cointegrated systems may involve nonstandard distribution and nuisance parameters, if $I(1)$ variables are not negligible in the statistics. To overcome this problem we construct a new statistic that takes only the $I(0)$ components of a Wald statistic into account and thus results in a valid $\chi^2$ criterion. Applying this procedure to test weak exogeneity in ECMs we obtain a simple and direct $\chi^2$ test
CLARIFICATIONS ABOUT NATURAL PHONOLOGY

This contribution argues that crucial as formalism is in computational linguistics and speech technology, Natural Phonology, with less rigid and less formalized claims, has important applications in the areas where language and not totally predictable human factors are involved. The paper discusses approaches to autonomy in language, explanation in Natural Phonology and applications of Natural Phonology.
Performance and Security Evaluation of Biometric-Based Web Application

Biometric recognition is the use of individual biometric physical or behavioural characteristics such as iris, retina, and fingerprint to uniquely identify the person. This technology offers a reliable and convenient solution to the problem of personal recognition. Fingerprint identification and verification system is the most widely used today due to ease of implementation and high performance. With the increase in the use of biometric systems in various sectors and organisations, there is increasing concern about the security and privacy of persons involved. Deploying a biometric system on the web makes it accessible by everybody thus preventing hackers and imposters that might exploit the system for their own gain. This paper evaluates the performance and security of biometric based web application, narrating the importance and challenges of using biometric to identify individuals in the web. To evaluate the system, Student Attendance Monitoring System was developed using java technology and MYSQL as the backend. The system involves scanning of student fingerprint using fingerprint scanner. Fifty (50) students were enrolled into the system and success rate of above 93% was recorded. The template is also secured due to the encrypted nature of the extracted template of the students fingerprint during enrolment and identification processes. Keywords : Web Application, Security, Performance, Biometrics
Structure of singly terminated polar dysco3 (110) surfaces

We have studied the polar surface of singly terminated DyScO3 (110) crystals by reflective high-energy electron diffraction, surface x-ray diffraction and angle-resolved mass spectroscopy of recoiled ions. These techniques show that the surfaces are (1 × 1) reconstructed, which points to the absence of ordered cation vacancies at the surface. The best surfaces were obtained after a selective chemical wet etch. We suggest that for ScO2 terminated surfaces, adsorbates, or oxygen vacancies are most likely to occur in order to overcome the polarity difference between stoichiometric bulk crystal and vacuum.
A PRELIMINARY STUDY ON THE SAFETY AND EFFICACY OF HD- 03/ES THERAPY IN PATIENTS WITH CHRONIC HEPATITIS B: A PROSPECTIVE CLINICAL STUDY

In-vitro studies indicated that HD-03 has surface antigen suppression and Hepatitis B (HBV) virus elimination activities. Acute and sub-acute toxicity studies indicated that HD 03/ES is devoid of significant toxicity following acute and repeated administration in rats. This study was undertaken to evaluate the safety and efficacy of the formulation HD-03/ES capsules in the management of patients with chronic hepatitis-B infection. An open clinical study was carried out in one hundred and six patients with chronic hepatitis-B infection and was treated with HD-03/ES capsules twice daily in the morning and evening for a period of six months. Clinical, biochemical and HBV markers were monitored before and after initiation of therapy . S tatistically significant improvements were observed in clinical, biochemical and HBV markers after administration of HD-03/ES capsules. Adverse effects were mild and never warranted withdrawal of the drug. The results of this preliminary study indicate that HD- 03/ES might be a safe and effective treatment for the treatment of chronic hepatitis-B.
Strike Activity Under Enterprise Bargaining: Economics or Politics?

Australia has moved rapidly from a centralised Award based wage determination system to decentralised enterprise bargaining. This move has been associated with a substantial drop in strike activity. The relationship between working days lost and a series of macroeconomic variables is tested for the period 1985 to 2003, incorporating dummy variables for the different pieces of industrial legislation and four major periods of political strike activity in that period. The economic variables proved mostly insignificant with only the CPI and business inventories having any association with changes in strike activity. Working days lost fell significantly with the introduction of enterprise bargaining. Both the Reform Act 1993 and the Workplace Relations Act 1996 were associated with below trend strike activity. Overall, these results indicate that institutional factors now influence strike volumes, rather than economic.
EVALUATING END-USER SATISFACTION WITH AN E-GOVERNMENT SERVICE ELECTRONIC LABOR EXCHANGE (ELX)

A major domain of e-government research has been the examination of information delivery to citizens. These services involve communications and transactions between government, at various levels, and citizens. The rise of these services has led to a concurrent need to develop models of citizen satisfaction with e-governmental services. This research aims to contribute to this need by devising an ELX Consumer Satisfaction Index (ELXCSI) model and using it to evaluate citizen satisfaction. This model includes various performance and emotional measures. To explore its applicability, the model is applied to electronic labor exchange (ELX), a form of government-to-citizen service delivery. This paper presents results of a statistical analysis of an end-user survey conducted in 2009 to evaluate user satisfaction with ELX. Using structural equation modeling, a highly statistically significant goodness-of-fit was found for the model, which included 15 measures capturing three constructs of performance dimensions (utility, efficiency, customization) as affecting three emotional dimension variables (confidence, pleasantness, satisfaction). The calculated ELXSCI of 66 indicates that more effort should be carried out to improve performance measurements in order to increase satisfaction among end-users of ELX in Malaysia.
ORGANIZATIONAL CITIZENSHIP BEHAVIOR (OCB), SERVICE QUALITY, AND PATIENT SATISFACTION: A CASE STUDY OF THE NURSES IN PRIVATE HOSPITALS OF SURABAYA

As a distinctive employee behavior, organizational citizenship behavior(OCB) plays an important role in shaping the quality of service provided by nurses tofurther enhance the feeling of satisfaction experienced by customers. This researchaims to explain the relationship between OCB, service quality, and patient satisfactionin hospital setting. We use the perception of costumers in explaining the threeconstructs used in this research. The respondents are 30 full time nurses and 100hospital inpatients of private hospitals (63.29% response rate) in private hospitals inSurabaya. SEM-PLS is used for the data analysis, yielding results that OCB haspositive and significant relationship towards service quality, and service quality haspositive and significant relationship towards customer satisfaction. Thus, the resultsconfirm previous researchers' findings. Future research direction is advised as therelationship between service quality and customer satisfaction is found to besignificantly weaker than previous researchers' results.
Fast Atomic Charge Calculation for Implementation into a Polarizable Force Field and Application to an Ion Channel Protein

Polarization of atoms plays a substantial role in molecular interactions. Class I and II force fields mostly calculate with fixed atomic charges which can cause inadequate descriptions for highly charged molecules, for example, ion channels or metalloproteins. Changes in charge distributions can be included into molecular mechanics calculations by various methods. Here, we present a very fast computational quantum mechanical method, the Bond Polarization Theory (BPT). Atomic charges are obtained via a charge calculation method that depend on the 3D structure of the system in a similar way as atomic charges of ab initio calculations. Different methods of population analysis and charge calculation methods and their dependence on the basis set were investigated. A refined parameterization yielded excellent correlation of . The method was implemented in the force field COSMOS-NMR and applied to the histidine-tryptophan-complex of the transmembrane domain of the M2 protein channel of influenza A virus. Our calculations show that moderate changes of side chain torsion angle and small variations of of Trp-41 are necessary to switch from the inactivated into the activated state; and a rough two-side jump model of His-37 is supported for proton gating in accordance with a flipping mechanism.
Google Scholar as a source for scholarly evaluation: A bibliographic review of database errors

Google Scholar (GS) is an academic search engine and discovery tool launched by Google (now Alphabet) in November 2004. The fact that GS provides the number of citations received by each article from all other indexed articles (regardless of their source) has led to its use in bibliometric analysis and academic assessment tasks, especially in social sciences and humanities. However, the existence of errors, sometimes of great magnitude, has provoked criticism from the academic community. The aim of this article is to carry out an exhaustive bibliographical review of all studies that provide either specific or incidental empirical evidence of the errors found in Google Scholar. The results indicate that the bibliographic corpus dedicated to errors in Google Scholar is still very limited (n= 49), excessively fragmented, and diffuse; the findings have not been based on any systematic methodology or on units that are comparable to each other, so they cannot be quantified, or their impact analysed, with any precision. Certain limitations of the search engine itself (time required for data cleaning, limit on citations per search result and hits per query) may be the cause of this absence of empirical studies.
Modeling Dependence in the Design of Whole Farm Insurance Contract |A Copula-Based Model Approach

Selected Paper prepared for presentation at the American Agricultural Economics AssociationAnnual Meeting, Orlando, Florida, July 27 - 29, 2008Copryright 2008 by Ying Zhu, Sujit K. Ghosh and Barry K. Goodwin. All rights reserved.Readers may make verbatim copies of this document for non-commercial purposes by anymeans, provided that this copyright notice appears on all such copies.
Some Recent Approaches in the Design of Synthetic Antitubercular Agents Containing Five‐Membered Heterocyclic Rings

The valuable treatment of tuberculosis is difficult, due to the complicated or unusual structure and chemical composition of the mycobacterial cell wall. These complex properties of cellwallmake many antibiotics and currently used drugs ineffective and hinder the entry of drugs in to the mycobacterium cells. Tuberculosis is still the one of the most crucial infectious disease worldwide. The most important complication in the treatment of tuberculosis is drug resistant multidrug (MDR-TB) and extensive drug resistant tuberculosis (XDR-TB), persistent infection or latent-TB and synergismof TBwith Human Immuno deficiencyVirus (HIV). Newchemical entities are required for the MDR-TB and XDR-TB. Furthermore not any newchemical entity has come in last 40 years for pontent and effective antitubercular drug against resistant strain. Currently available data from the recently doveloped antitubercular drugs which containing five membered heterocyclic ring system. The modern drug design promises to bring significant development for effectiveness against tuberclosis. In present review we discussed brief introduction of recently doveloped antitubercular agents containing five membered heterocylic rings in their structures.
Radical Technological Innovation: Case Study of the P1.18 Bicycle Transmission by Pinion

To shed some light on the concrete factors that determine success of radical technological innovations a concrete case of such an innovation will be studied. In 2008, two engineers founded the Pinion GmbH to develop and exploit a new bicycle transmission concept as competitive shifting system for bicycles to overcome the existent disadvantages of traditional derailleur systems and internal gear hubs.
Primordial Non-Gaussianities from Inflation Models

This is a pedagogical review on primordial non-Gaussianities from inflation models. We introduce formalisms and techniques that are used to compute such quantities. We review different mechanisms which can generate observable large non-Gaussianities during inflation, and distinctive signatures they leave on the non-Gaussian profiles. They are potentially powerful probes to the dynamics of inflation. We also provide a nontechnical and qualitative summary of the main results and underlying physics.
MicroRNA Upregultion in MKN-45 Gastric Cancer Cell Line by Ibuprofen Treatment: Highlighting the Importance of miR-22

Nonstroidal anti-inflammatory drugs (NSAIDs) including ibuprofen have been shown to decrease the growth of cancer cells. Owning to the involvement of microRNAs in development of cancer, the aim of this study was to evaluate the effect of ibuprofen on the expression level of some microRNAs including hsa-miR-4290, hsa-miR-22 and hsa-Let-7b in MKN-45 cells. First, the growth inhibitory effect of ibuprofen on MKN-45 was evaluated using MTT and trypan blue exclusion assays. Second, the gene expression level of micoRNAs was evaluated using real-time PCR. Timeand dose-dependent proliferation reduction was seen in MKN-45 gastric cancer cells treated with ibuprofen. Results showed that ibuprofen treatment increased the expression level of miR-4290, miR-22 and Let-7 by 2.14, 57.8 and 1.58 folds, respectively, relative to control MKN-45 cells. Results clearly highlighted the fact that miR-22 plays a critical role in growth inhibition of ibuprofen treated MKN-45 gastric cancer cells. Therefore, we concluded that overexpression of these microRNAs in ibuprofen-treated MKN-45 clearly indicated the tumor suppressor role of them in gastric cancer prevention.
A New Approach to Wide Bandwidth Energy Harvesting for Piezoelectric Cantilever Based Harvesters

This thesis proposes a control system to widen the bandwidth of piezoelectric transducers (PZTs) for vibration energy harvesting while extracting maximum power. A straightforward complex conjugate match achieves maximum power transfer only at a single frequency while requiring an impractically large inductance. The proposed system intends to address these problems. It incorporates a bi-directional DC/DC converter with feed-forward control to achieve a complex conjugate match over a wide range of frequencies. Analysis of the proposed system and simulation results are presented to verify validity of the proposed method.
EFFECTS OF VARYING LEVELS OF DCAD WITH TWO LEVELS OF MG AND K ON ACID BASE STATUS, MG METABOLISM AND PRODUCTIVE PERFORMANCE OF BEETAL GOATS

Thirty-six Beetal goats in early lactation were used in a 6-wk experiment with a 3 x 2 x 2 factorial arrangement of treatments. The objective was to reveal the effects of three levels of DCAD ( -15, 2.5 and 20mEq/100g of feed DM) with two levels of K (1.35 and 2.0% of feed DM) and two levels of Mg (0. 37 and 0.74%) in diets on productive performance. Increasing DCAD levels in diets significantly increased DMI, milk yield and milk fat percentage. Moreover, increasing K levels in diets increased milk yield of goats. However, increasing Mg levels in diets from 0.37% to 0.74% of feed DM negatively influenced the DMI intake, DM digestibility, milk yield and milk protein contents, as all the traits were reduced by increasing Mg levels. A linear increase in pH and HCO 3 − contents of blood and urine by increasing DCAD levels in diets evidenced a positive alteration in acid base status of the animals. However, K and Mg l evels of diets showed no effect on same traits. Moreover, increasing K levels of diets reduced the Mg absorption. Similarly, higher Mg absorption, retention and balance were observed when added Mg was increased in diets. Overall, increasing DCAD levels in diets improved DMI and milk yield (3.5 and 11.1%, respectively), however, increasing Mg levels in diets showed negative effects on productive performance of Beetal goats.
Locality-constrained Linear Coding for Vehicle Color Recognition

Automobile information recognition is a key component of intelligent transportation system which gains its popularity on the basis of a rapidly developing society. Color plays an important role in vehicle identification. Given that every vehicle has its own inner structure, and the outer natural environment deforms its main color to some extend in images, the toughest problem of vehicle color recognition is to pick out the region of interest (ROI), which means vehicle body, for identifying its main color. In this paper, we propose a method which combines Bag-of-Word (BoW) and Locality-constrained Linear Coding (LLC) for color recognition whilst preprocessing is introduced to offset the impact made by image degradation. Then, we train the classifier by support vector machine. The experiments are validated on the data set, which are gathering on express ways. The proposed method achieves good effect.
Routing Method to Extend Network Lifetimein Wireless Sensor Network

The application of wireless sensor network consists of a wide variety of circumstances such as environmental observation, intrusion detection, and battlefield surveillance. The network is composed of a significant number of nodes distributed in a different area in which not all nodes are directly connected. These nodes are equipped with limited with battery power and capable of wireless communication. Resource limitation has to be taken care while designing wireless sensor network infrastructure. In wireless sensor network how to conserve the limited power source to extend the network lifetime.In this paper we proposed a EASR(energy aware sink relocation) to extend the network life time which deals with the residual battery energy of each sensor nodes to adjust the transmission range and relocate the sink.
COMPARISON OF SEMI-AUTOMATIC AND AUTOMATIC SLICK DETECTION ALGORITHMS FOR JIYEH POWER STATION OIL SPILL, LEBANON

After air strikes on July 14 and 15, 2006 the Jiyeh Power Station started leaking oil into the eastern Mediterranean Sea. The power station is located about 30 km south of Beirut and the slick covered about 170 km of coastline threatening the neighboring countries Turkey and Cyprus. Due to the ongoing conflict between Israel and Lebanon, cleaning efforts could not start immediately resulting in 12 000 to 15 000 tons of fuel oil leaking into the sea. In this paper we compare results from automatic and semi-automatic slick detection algorithms. The automatic detection method combines the probabilities calculated for each pixel from each image to obtain a joint probability, minimizing the adverse effects of atmosphere on oil spill detection. The method can readily utilize X-, C- and L-band data where available. Furthermore wind and wave speed observations can be used for a more accurate analysis. For this study, we utilize Envisat ASAR ScanSAR data. A probability map is generated based on the radar backscatter, effect of wind and dampening value. The semi-automatic algorithm is based on supervised classification. As a classifier, Artificial Neural Network Multilayer Perceptron (ANN MLP) classifier is used since it is more flexible and efficient than conventional maximum likelihood classifier for multisource and multi-temporal data. The learning algorithm for ANN MLP is chosen as the Levenberg-Marquardt (LM). Training and test data for supervised classification are composed from the textural information created from SAR images. This approach is semiautomatic because tuning the parameters of classifier and composing training data need a human interaction. We point out the similarities and differences between the two methods and their results as well as underlining their advantages and disadvantages. Due to the lack of ground truth data, we compare obtained results to each other, as well as other published oil slick area assessments.