Miracle-dz/UniFAR-FTUs huggingface dataset:
Dose- and age-dependent effects of prenatal ethanol exposure on hippocampal metabotropic-glutamate receptor-stimulated phosphoinositide hydrolysis.

Prenatal ethanol exposure reduces the density of the N-methyl-D-aspartate (NMDA) receptor agonist binding sites and decreases the capacity to elicit long-term potentiation (LTP) in hippocampal formation of 45-day-old rat offspring. We hypothesized that prenatal ethanol exposure would reduce metabotropic-glutamate receptor (mGluR)-activated phosphoinositide hydrolysis also. Sprague-Dawley rat dams were fed a liquid diet containing either 3.35% (v/v) ethanol or 5.0% ethanol throughout gestation. Control groups were pair-fed either isocalorically matched 0% ethanol liquid diets or lab chow ad libitum. (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (trans-ACPD) stimulated inositol-1-phosphate (IP1) accumulation via activation of the mGluR in offspring whose mothers consumed the 3.35% ethanol liquid diet was not different compared with the control groups. Furthermore, trans-ACPD stimulated IP1 accumulation in 10- to 13-day-old offspring of the 5.0% ethanol diet group was not different compared with the control groups. However, trans-ACPD stimulated IP1 accumulation was reduced significantly in 56- to 82-day-old offspring of dams fed the 5.0% ethanol liquid diet compared with the control groups. In contrast, bethanechol stimulated IP1 accumulation, mediated via activation of muscarinic cholinergic receptors, was not affected by maternal consumption of either ethanol liquid diet. These results suggest both dose- and age-dependent effects of prenatal ethanol exposure on hippocampal responsiveness to trans-ACPD-activated phosphoinositide hydrolysis. Furthermore, the ability of the 3.35% ethanol diet to alter hippocampal NMDA receptors without altering the mGluR response suggests a differential sensitivity to the effects of ethanol exposure in utero among hippocampal glutamate receptor subtypes. (ABSTRACT TRUNCATED AT 250 WORDS)
Frequency performances of reflectarray element with varactor-loaded radial phasing line

A simplified circuit-model approach is presented in this work to analyze the behavior of a novel broadband varactor loaded phasing line, specifically designed to improve the frequency performances of aperture-coupled reflectarray cell, and able to offer a useful degree of frequency agility. The proposed approach provides a simple but effective demonstration of the enhanced frequency performances of the adopted radial line geometry with respect to standard linear phasing line configurations.
Virologic and Immunologic Response, Clinical Progression, and Highly Active Antiretroviral Therapy Adherence

Summary: A growing body of evidence suggests that a high degree of adherence is required to achieve and maintain a successful virologic response both in the short and long term. This holds true despite the definition of adherence or how it is measured. Reported differences in the degree of adherence required are likely due to differences in study design, difficulty measuring patient adherence, patient population studied, and the antiretroviral regimen studied. Virologic suppression and immunologic response often go hand in hand, but the impact of adherence on change in CD4 count tends to be delayed and, therefore, less apparent than the impact on HIV viral load. Degree of adherence has also been shown to be associated with AIDS‐related morbidity, mortality, and hospitalizations.
Myocardial Infarction in the Young *

We reviewed the records of 2,400 consecutive patients undergoing cardiac catheterization at USAF Medical Center Keesler between 1978 and 1984 and found 35 patients (1.5 percent of all cardiac catheterizations) aged 35 years or less (mean age, 32 years) who underwent cardiac catheterization after myocardial infarction. These 35 patients (group 1) were compared to a randomly selected group of 100 patients (group 2) aged 55 years or greater who underwent cardiac catheterization for evaluation of coronary artery disease during the same period. The two groups were compared in terms of angiographic features and risk factors for coronary artery disease. The patients in group 1 had a higher proportion of normal coronary arteries (14 percent [5 patients] vs 0; p<O.Ol) and singlevessel disease compared to group 2, while the incidence of
Clinical Applications of Otoacoustic Emissions in Sudden Hearing Loss

Sudden hearing loss (SHL) is a controversial topic for which no definitive practical guidelines exist. Studies employing vasodilators, plasma expanders, anticoagulants, and carbogen inhalations have shown no improvement over the rate of spontaneous recovery. At present, there is insufficient evidence to support medical treatment for SHL, except steroid therapy in selected patients. Distortion product otoacoustic emissions (DPOAEs) are sensitive to cochlear disorders and are absent in ischemic injury to the cochlea, but can persist in cochlear neuritis. In a prospective study of 10 patients who presented to Albany Medical Center from 1995 to 1996, three patients with intact DPOAEs at presentation had an average improvement of 33 dB in the pure‐tone average (PTA) of 0.5, 1.0, and 2.0 kHz with steroid therapy, whereas five of seven patients with absent DPOAEs had no improvement in hearing despite steroid therapy in six patients. The presence of DPOAEs may be a useful prognostic factor that positively correlates with recovery from SHL.
Analyse et modélisation du mouvement de préhension

Les objectifs de cette these sont de developper un modele cinematique de la main, integre dans le mannequin numerique MAN3D, capable de reproduire et de simuler de la maniere la plus realiste possible, des postures de prehension et d’exploiter ce modele pour realiser une base de donnees de postures de prehension. La demarche mise en œuvre a tout d’abord ete experimentale, pour le choix des objets et des postures a reproduire mais aussi pour determiner les axes de mouvement au niveau de l’articulation trapezo-metacarpienne du pouce. Puis, un nouveau modele cinematique de la main a ete developpe, plus proche de l’anatomie fonctionnelle que les modeles existants, avec comme principale amelioration la possibilite de deformer la paume en realisant l’arche metacarpienne. Suite au developpement de ce nouveau modele, celui-ci a ete integre dans l’environnement du mannequin numerique MAN3D. Ce modele a enfin ete exploite pour la realisation d’une base de donnees des postures de la main, a partir de donnees experimentales. Des validations qualitatives et quantitatives du modele ont ensuite ete effectuees
A 16b 250MS/s IF-sampling pipelined A/D converter with background calibration

Wireless communication applications have driven the development of high-resolution A/D converters (ADCs) with high sample rates, good AC performance and IF sampling capability to enable wider cellular coverage, more carriers, and to simplify the system design. We describe a 16b ADC with a sample rate up to 250MS/s that employs background calibration of the residue amplifier (RA) gain errors. The ADC has an integrated input buffer and is fabricated on a 0. 18µm BiCMOS process. When the input buffer is bypassed, the SNR is 77.5dB and the SFDR is 90dB at 10MHz input frequency. With the input buffer, the SNR is 76dB and the SFDR is 95dB. The ADC consumes 850mW from a 1.8V supply, and the input buffer consumes 150mW from a 3V supply. The input span is 2.6Vp-p and the jitter is 60fs.
Browsing Multidimensional Molecular Networks with the Generic Network Browser (N‐Browse)

N‐Browse is a graphical network browser for the visualization and navigation of heterogeneous molecular interaction data. N‐Browse runs as a Java applet in a Web browser, providing highly dynamic and interactive on‐demand access to network data available from a remote server. The N‐Browse interface is easy to use and accommodates multiple types of functional linkages with associated information, allowing the exploration of many layers of functional information simultaneously. Although created for applications in biology, N‐Browse uses a generic database schema that can be adapted to network representations in any knowledge domain. The N‐Browse client‐server package is freely available for distribution, providing a convenient way for data producers and providers to distribute and offer interactive visualization of network‐based data. Curr. Protoc. Bioinform. 23:9.11. 1‐9.11. 21. © 2008 by John Wiley & Sons, Inc.
Effect of the neutral CLOTS 1 trial on the use of graduated compression stockings in the Efficacy of Nitric Oxide Stroke (ENOS) trial

Background and purpose Current evidence suggests that the time lag from the publication of randomised clinical trial results to changes in prescribing behaviour for drugs is gradually reducing. However, the effect of results of clinical trials of devices and non-pharmacological interventions on clinical practice is less clear. Methods Prospective data from the ongoing international ‘Efficacy of Nitric Oxide Stroke’ (ENOS) trial were analysed to assess the use of graduated compression stockings (GCS) for deep vein thrombus (DVT) prophylaxis in acute stroke patients before and after publication of the large ‘Clots in Legs Or sTockings after Stroke’ (CLOTS-1) trial. Results Data on GCS use were available for 1971 patients with acute stroke enrolled into ENOS from February 2003 to April 2011; of these, 498 (25.3%) wore GCS. Prior to publication of CLOTS-1, GCS use was common (>50%) in the UK, Australasia and Canada but infrequent in Asia and the rest of Europe. After publication of CLOTS-1, use of GCS in the UK declined from 398/656 (61%) to 20/567 (4%) (p<0.001) but not elsewhere (eg, in Australasia (57% before publication vs 70% after publication, p=0.24, but based on small numbers). Practice change was apparent within 3 months of the study publication and was sustained thereafter. There was no change in DVT rates before and after CLOTS-1 (0.8% vs 1.0%). Conclusions GCS use declined dramatically following the reporting of the CLOTS-1 trial. The results support the notion that a neutral trial of a device can influence clinical practice rapidly, which is important with a widely used and moderately expensive (time and finance) intervention.
Attitudes towards collaboration and servant leadership among nurses, physicians and residents

A descriptive, comparative study was conducted to examine the attitudes of nurses, physicians and residents towards collaboration and to assess their self-perception of servant leadership characteristics. The Jefferson Scale of Attitudes toward Physician-Nurse Collaboration and the Barbuto-Wheeler Servant Leadership Questionnaire were utilized for data collection. Registered nurses (RNs) (n = 2,660), physicians (n = 447) and residents (n = 171) in a Southeastern United States health system were surveyed via the intranet; there were 497 responses for analysis. The response rate should be considered and generalizations made with caution regarding the study results. RN scores were higher for both total scores and subscales as compared to physician/resident groups for collaboration and servant leadership. There was a weak positive correlation between collaboration and servant leadership in the RN group and no significant correlation between the variables in the physician/resident group. Findings from this study have implications for nursing and physician education and practice and may serve as a framework for future studies. Representative samples are needed to gain further insight and to guide future research.
The role of gender in family-business research : A systematic review of the literature

Despite several calls for more systematic research on the role of gender aspects for entrepreneurial family businesses, rather little research on such topics has been published in the leading family business journals. More research has been published in niched or lower-ranked journals as well as books. The aim of this chapter is to provide a systematic literature review of the intersection between gender and family business research published in different kinds of outlets, outlining the status quo of the discussion along different themes as well as a research agenda to help move the field forward.
Estimation of Magnetization Transition Width and Shape by Inverse Reciprocity

Very narrow transition width must be attained to achieve areal densities greater than 1 Tbit/inch2. Not only the grain size, but also the grain switching behavior of the recording medium should be considered. In this paper, the magnetization distribution is calculated by an inverse reciprocity operation on the measured readback waveform obtained from a spin-stand. The calculated magnetization distribution at the transitions between bits was less steep than the error function, which suggested the presence of island-like switched grains away from the transition line due to the finite head field gradient and switching field distribution.
QoS-aware dynamic resource management in heterogeneous mobile cloud computing networks

In mobile cloud computing (MCC) systems, both the mobile access network and the cloud computing network are heterogeneous, implying the diverse configurations of hardware, software, architecture, resource, etc. In such heterogeneous mobile cloud (HMC) networks, both radio and cloud resources could become the system bottleneck, thus designing the schemes that separately and independently manage the resources may severely hinder the system performance. In this paper, we aim to design the network as the integration of the mobile access part and the cloud computing part, utilizing the inherent heterogeneity to meet the diverse quality of service (QoS) requirements of tenants. Furthermore, we propose a novel cross-network radio and cloud resource management scheme for HMC networks, which is QoS-aware, with the objective of maximizing the tenant revenue while satisfying the QoS requirements. The proposed scheme is formulated as a restless bandits problem, whose “indexability” feature guarantees the low complexity with scalable and distributed characteristics. Extensive simulation results are presented to demonstrate the significant performance improvement of the proposed scheme compared to the existing ones.
Some Reflexions on the Selfunderstanding of the Kazakh People: A Way of Building Identity in the Modern World

This article explores the self-identity of the Kazakh people by way of identifying the roots of self-understanding in Kazakh culture. Unfortunately, Western methods of ethno psychology cannot fully capture what is unique about identity in Kazakh culture. Although Kazakhstan is the ninth largest country in terms of geographical space, Kazakh cultural identity is not wellknown in the West. In this article we offer an account of the national psychological features of the Kazakh people, in order to reveal the spiritual, mental, ethical dimensions of modern Kazakhs. These factors play a central role in the revival of forms of identity that are central to the Kazakh people. Keywords—self-understanding, ethno psychology, stereotypes, nomadic culture, cultural identity
Diversity Management in Czech Republic as an Answer to Demographic Changes

Purpose – The main objective of the following article is to present issues associated with managing diversity in the context of demographic changes. The aim of this paper is to offer concrete suggestions on how organizations can overcome demographic changes and tap the business potential of diversity management. Design/Methodology/Approach – The authors’ approach is based on the literature, statistic data and authors’ own research. The empirical part was developed on the basis of survey research titled “Diversity Management in the V4 Countries as an Answer to Demographic Changes”. The research was quantitative, implemented through the computer-assisted personal interviewing (CAPI) technique on a group of 101 respondents. The research study was conducted in 2016–2017. Findings – According to the research, knowledge and practice of diversity management is not very widespread in the Czech Republic. The research has shown that according to the opinion of the respondents from organisations, they recognize differences in motivation factors for specific groups of employees. The majority of respondents see the values and benefits of different groups of employees, as well as their specific needs. The majority of respondents know that specific groups can be the objects of various types of discrimination. Practical implications – Changes taking place on the labour market and globalization – and in particular the demographic changes in the Czech Republic – have evoked a necessity of searching for new strategies of management. Contemporary human resources management strategies should take into account social and demographic changes and the influence of those changes on customer purchase behaviour and requirement. Therefore, knowledge of diversity management and practical applications should be reflected in strategies of organizations. Results of the study provide general guidelines for determining the direction of how important diversity management should be in organizations. Originality/value – The research concerns diversity management in the Czech Republic with respect to demographic changes.
Nefazodone for social phobia: A clinical case series

A number of pharmacological agents, including the monoamine oxidase inhibitors, benzodiazepines, selective serotonin reuptake inhibitors, and beta blockers, have proven effective for the treatment of social phobia. Nefazodone, a relatively novel antidepressant, has demonstrated potential efficacy for the treatment of panic disorder but has not been formally studied in patients with social phobia. The authors conducted a clinical case study in which five consecutive patients meeting DSM‐IV criteria for generalized social phobia were treated with nefazodone (dose range: 200–600 mg/day) for 3 months. Three of the patients completed all 3 months of the treatment, one discontinued after 2½ months due to adverse gastrointestinal effects and one discontinued after 2 months due to lack of efficacy. The patients completed the Liebowitz Social Phobia Scale and the Sheehan Disability Scale at every clinic visit, and were evaluated by the clinicians with the Brief Social Phobia Scale and CGI‐Severity and CGI‐Improvement scales. Analysis of endpoint data demonstrated significant improvement on most measures of outcome. Results from this case series suggest that nefazodone may be an effective treatment for social phobia and that formal randomized trials are warranted. Depression and Anxiety 8:131–133, 1998. © 1998 Wiley‐Liss, Inc.
An Adaptive and Real-Time Fraud Detection Algorithm in Online Transactions

While the Internet has made it possible to transact electronically and ubiquitously, some unscrupulous internet users have devised ways of defrauding e-commerce users. Several solutions have been designed and deployed to try and curb fraud in electronic transactions, but the news of fraud in e-commerce continues making the headlines globally. It is against this background that the researcher was motivated to design an adaptive algorithm that can detect credit card fraud as it occurs (real-time). The solution is based on the use of an Artificial Neural Network, Hidden Markov Model and a One-Time Password. The researcher used a synthesised dataset since a real dataset could not be found. The researcher tested the algorithm, which produced 100 per cent fraud detection rate and 98 per cent accuracy. The proposed solution can be made a plugin to e-commerce sites for the purposes of detecting and preventing fraud. The researcher was motivated to undertake this study after realising that while Zimbabwe is calling for the adoption of e-commerce due to the prevailing cash crisis, some people still have reservations due to security concerns. Despite, even in those countries where electronic commerce was adopted a long time ago, security is still a concern among e-commerce participants. The designed algorithm has a learning ability so that it can detect new fraud variations as they occur (real-time) and thus terminate the transaction should it be considered a fraudulent one. The author seeks to restore and instill confidence in people who transact online using credit cards.
Entrepreneurial Storytelling, Future Expectations, and the Paradox of Legitimacy

Prior research highlights storytelling as a means for entrepreneurs to establish venture legitimacy and gain stakeholder support. We extend this line of research by examining the role that projective stories play in setting expectations and the dynamics that ensue. Such attention highlights a paradox-the very expectations that are set through projective stories to gain venture legitimacy can also serve as the source of future disappointments. Because of inherent uncertainties that projective stories mask, ventures will likely deviate from their early projections, thereby disappointing stakeholders. This, in turn, can result in a loss of legitimacy. Recognizing that entrepreneurship is an ongoing process, we examine the constraints and possibilities of maintaining or regaining legitimacy through revised storytelling. We conclude the paper with implications for research on entrepreneurial storytelling as an ongoing process.
Induced Preterm Birth in Sheep: A Suitable Model for Studying the Developmental Effects of Moderately Preterm Birth

Our aim was to characterize an ovine model of preterm birth that allows analysis of the developmental effects of preterm birth in the absence of postnatal confounding factors. Preterm birth was induced at 131 days of gestation in 82 lambs; controls (n = 31) were born at term (145 days). Overall survival of preterm lambs was 60%; males had significantly lower survival than females (44% vs 76%); 94% of term lambs survived. Although the birth weight of preterm lambs was ∼0.9 kg lower than in term lambs, the crown-to-rump and forelimb lengths were similar. At 9 weeks after term-equivalent age, there were no differences in body weight or dimensions between preterm and term lambs; when adjusted for body weight, the heart was 21% heavier in preterm than term lambs. We conclude that moderately preterm birth in sheep is characterized by a greater survival of female lambs than males and has significant effects on organ development.
The care management institute: harvesting innovation, maximizing transfer.

With the goal of “making the right thing easier,” the Care Management Institute (CMI) is a central hub where evidence-based guidelines, innovative population care management programs, and rigorous common measurement systems are created for an identified set of priority conditions. Implementation of guidelines and programs is local, allowing regions to maximize impact by leveraging products, tools, services, and new technologies in ways that best suit their operational structures. CMI harvests the experiences of regions to refine and extend programs, cycling the next level of innovation back to clinicians in the field. This model of distributed learning underlies all Kaiser Permanente (KP) population care management activities, maximizing innovation efficiency, supporting “grassroots” program improvements, and empowering clinicians in population care management strategies. CMI also champions efficiency. “In the past, one quality improvement approach was to solve every problem by innovating a new solution. However, innovation has a time cost, and responsible resource stewardship demands that we focus innovation on cutting edge issues that have yet to be addressed,” says Paul Wallace, MD, CMI Executive Director. From its inception, CMI recognized the importance of collaborating with clinicians in all aspects of program development, implementation, and measurement, building structured relationships between CMI at the national level and regional teams of clinicians, implementation specialists, and analysts. The following programs are illustrative of CMI's approach to innovation and transfer.