Miracle-dz/UniFAR-FTUs huggingface dataset:
Emerging mechanisms in morphogen‐mediated axon guidance

Early in animal development, gradients of secreted morphogenic molecules, such as Sonic hedgehog (Shh), Wnt and TGFβ/Bmp family members, regulate cell proliferation and determine the fate and phenotype of the target cells by activating well‐characterized signalling pathways, which ultimately control gene transcription. Shh, Wnt and TGFβ/Bmp signalling also play an important and evolutionary conserved role in neural circuit assembly. They regulate neuronal polarization, axon and dendrite development and synaptogenesis, processes that require rapid and local changes in cytoskeletal organization and plasma membrane components. A key question then is whether morphogen signalling at the growth cone uses similar mechanisms and intracellular pathway components to those described for morphogen‐mediated cell specification. This review discusses recent advances towards the understanding of this problem, showing how Shh, Wnt and TGFβ/Bmp have adapted their ‘classical’ signalling pathways or adopted alternative and novel molecular mechanisms to influence different aspects of neuronal circuit formation.
Response of Epiphytic Algae to Heavy Pollution of Water Bodies

The objective of the present work was to study the structure of epiphyton in water bodies significantly differing in the degree of their contamination. In the studied water bodies, the concentration of ammonia () accounted for 0.04–74.00 mg/L; nitrite (), 0.002–1.750 mg/L; nitrate (), 0.13–58.00 mg/L; inorganic compounds of phosphorus (Pinorg), 0.041–0.272 mg/L; chloride (Cl−), 34.5–560.5 mg/L; whereas the content of organic matter (DO) was 18.0–81.0 mg O/L. The numbers of algae were determined by a direct count. Biomass was calculated by the count cell volume method. The Generic Diatom Index, the Pantle‐Buck saprobic index, and the Shannon index of species diversity were used to analyze algal community structure. This study found that epiphyton responded to heavy pollution with changes in its species richness, taxonomic structure, species composition, quantitative indices, numbers and biomass structure, dominant complex, and ecological spectrum.
Early cardiac dysfunction is rescued by upregulation of SERCA2a pump activity in a rat model of metabolic syndrome

Various components of metabolic syndrome associate with cardiac intracellular calcium ( Cai 2+ ) mishandling, a precipitating factor in the development of heart failure. We aimed to provide a thorough description of early stage Cai 2+ ‐cycling alterations in the fructose‐fed rat, an experimental model of the disorder, where insulin resistance, hypertension and dyslipidaemia act cooperatively on the heart.
Modelo de capital intelectual de la Consejería de Educación de la Junta de Andalucía. Indicadores de capital humano y gestión del conocimiento

La identificacion, valoracion y gestion de los activos intangibles basados en el conocimiento es un tema de maxima actualidad, aunque algunas de las ideas claves del Capital Intelectual son antiguas y se remontan a los anos finales del siglo XVIII y primeros del XIX. A finales del siglo XX y principios del siglo XXI surgieron en el ambito privado muchos y variados modelos que tratan sobre la medicion y gestion de estos activos intangibles basados en elconocimiento. Sin embargo, en el Sector Publico, el interes demostradopor estos temas ha sido mucho menor, y sobre todo, han sido muy escasos los intentos que se han hecho de implantacion o adaptacion de estos modelos, a pesar de que la intangibilidad esta incluso mas presente en el Sector Publico que en el privado. Con esta Tesis doctoral se pretende contribuir a despertar el interes por la Gestion del Conocimiento y el Capital Intelectual en el ambito publico, aportando un modelo de medicion y gestion de activos intangibles basados en el conocimiento referido a la Consejeria de Educacion de la Junta de Andalucia.
Rapid three-dimensional surface mesh segmentation based on region dilation

Three-dimensional laser scanned surface segmen- tation is an important step for computer-aided broken objec- tion patching. Current methods still have high time consuming problem in practical applications. In order to solve this pro- blem, we propose the rapid three-dimensional (3-D) surface segmentation based on region dilation. The procedure includes three steps of point cloud meshing, candidate region generating, and insignificant region eliminating. Some experi- ments are implemented on the 3-D surface with a Roland LPX-250 3-D laser scanner to testify the feasibility and perfor- mance of the proposed algorithm compared with other methods. © 2012 Society of Photo-Optical Instrumentation Engineers
Functional Endothelin Receptors Are Present on Nuclei in Cardiac Ventricular Myocytes*

Endothelins are thought to act through two specific, plasmalemmal G protein-coupled receptor subtypes, ETAR and ETBR. However, in subfractionated cardiac membranes, ETAR immunoreactivity was detected only in the plasma membrane whereas ETBR immunoreactivity was detected predominantly in membranes of intracellular origin. Confocal microscopy demonstrated the presence of intracellular ETAR and ETBR in ventricular myocytes. ETAR were primarily on plasma membrane (surface membranes and transverse-tubules) and to a lesser extent on the nucleus while ETBR localized primarily to the nuclei. Western blot analysis of nuclei isolated from the heart indicated the presence of endothelin receptors: both ETAR and ETBR copurified with nucleoporin 62, whereas markers of endoplasmic reticulum and Golgi membranes were depleted. Radioligand binding studies revealed that isolated nuclei contain specific [125I]ET-1 binding sites. Specific [125I]ET-1 binding was reduced by 70–80% using the ETAR-selective antagonist BQ610 and 20–30% using the ETBR-specific antagonist BQ788. IRL-1620, an ETBR-specific agonist, also reduced [125I]ET-1 binding. Furthermore, ET-1 and IRL-1620 altered the incorporation of 32P into nuclear proteins and caused a transient increase in nuclear Ca2+ concentration. Hence, cardiac nuclei possess both ETAR and ETBR subtypes, which are functional with respect to ligand binding and are coupled to signaling mechanisms within the nuclear membrane.
Vulpes Ferrilata (Carnivora: Canidae)

Abstract The canid Vulpes ferrilata Hodgson, 1842, is commonly called the Tibetan sand fox, or sand fox. It is widely distributed in the steppes and semideserts of the Tibetan Plateau north through central China. V. ferrilata has thick fur adapted for cold climate, and it occurs in semiarid to arid upland plains, on barren slopes and hills at elevations of 2,500–5,200 m, most typically above 3,500 m in China. It is hunted for pelts, which are manufactured into hats in Tibet, and hunting and habitat destruction are the main threats to populations of V. ferrilata in Sichuan Province, China. The International Union for the Conservation of Nature and Natural Resources (World Conservation Union) lists V. ferrilata as a species of “Least Concern. ”
Optimal functional split selection and scheduling policies in 5G Radio Access Networks

We theoretically study the joint functional split selection and scheduling problem that arises in a Centralized Radio-Access-Network (C-RAN) architecture with a central location connected to a set of Remote Radio Heads (RRHs) through fronthaul links. We consider a static scenario where a set of LTE frames at the central location need to be transported to RRHs through the fronthaul topology. One frame is destined towards one RRH and contains data to be transmitted to users in that RRH. For each frame, a functional split needs to be selected out of a discrete set of available options, where each option corresponds to a different split of the baseband processing load between the server at the central location and the one residing at the RRH. A functional split also requires that a certain amount of data traverses the fronthaul link to the RRH. Prior to transmission, frames need to be scheduled for processing at the central location server. The total latency experienced by the frame is the sum of computation, data communication and scheduling delays, and it depends on both the schedule and the functional split selection. We seek to characterise the complexity of the joint functional split selection and scheduling policy that minimizes total latency or the maximum latency over all RRHs. The former objective becomes equivalent to a constrained shortest-path problem which is NP-Hard, although the scheduling problem for given functional splits and the functional split selection problem for given scheduling policy are polynomially solvable. The latter objective is also NP-Hard, while the problem of scheduling for given functional splits is optimally solvable through its equivalence to single-machine scheduling for maximizing lateness, and the functional split selection problem for fixed schedule is a mixed-integer linear program.
Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus

Micro-RNAs constitute a family of small noncoding ribonucleic acids that are posttranscriptional regulators of messenger RNA activity. Although micro-RNAs are known to be dynamically regulated during neural development, the role of micro-RNAs in brain aging and neurodegeneration is not known. This study examined micro-RNA abundance in the hippocampal region of fetal, adult and Alzheimer's disease brain. The data indicate that micro-RNAs encoding miR-9, miR-124a, miR-125b, miR-128, miR-132 and miR-219 are abundantly represented in fetal hippocampus, are differentially regulated in aged brain, and an alteration in specific micro-RNA complexity occurs in Alzheimer hippocampus. These data are consistent with the idea that altered micro-RNA-mediated processing of messenger RNA populations may contribute to atypical mRNA abundance and neural dysfunction in Alzheimer's disease brain.
The US Navy enterprise resource planning architecture

This paper presents the design of the US Navy's enterprise resource planning (ERP) architecture, which takes the as-configured baseline across multiple ERP projects, and transforms it into a converged to-be integrated solution. The result is an architecture-based instance consolidation that is unique; for the Navy solution is the first architecture-driven instance consolidation.
Toward Practical Verification of Outsourced Computations Using Probabilistically Checkable Proofs (PCPs)

This paper describes preliminary results and outlines the plan of attack for an on-going project to develop a practical system for verifying outsourced computations. We want a client to be able to describe a computation to a server, get back a purported output and some auxiliary information, and use that auxiliary information to verify that the output is correct. For outsourcing to be worthwhile, the verification process should be substantially more efficient than simply executing the computation. Our approach to this problem is to exploit the theory of probabilistically checkable proofs (PCPs). Specifically, our project seeks to build a bridge between the theory and an implementable system. We describe a protocol for outsourced computation that includes algorithmic refinements of the PCP protocol and end-to-end instantiation of the necessary steps (e.g., compilation to a form suitable for application of the PCP theorem). Although we are in the process of implementing the protocol and do not have experimental results, we present a detailed analysis that provides cause for optimism: our cycle and memory usage costs strongly suggest that our system will be useful. We focus on the example of matrix multiplication, where we show that for large matrices, our method achieves enormous savings for the client and requires feasible amounts of bandwidth.
Downlink channel covariance matrix (DCCM) estimation and its applications in wireless DS-CDMA systems

The downlink channel covariance matrix (DCCM) is of vital importance in determining downlink beamforming weights for base station (BS) antenna array systems. For the frequency-division-duplex (FDD) mode, DCCM is difficult to obtain due to a lack of direct measurement of downlink channel responses. In this paper, a novel technique is proposed for estimating DCCM using uplink channel responses only, which does not need direction-of-arrival (DOA) estimation and its association. The downlink beamforming scheme is then proposed for wireless DS-CDMA systems, using the obtained DCCM information together with the so-called virtual uplink beamforming and power control technique. Computer simulations show that using the BS antenna array together with this new beamforming technique can provide larger system capacity than traditional DOA-based approaches, which just direct the main beam toward the desired user.
Numerical 2D methodology for synchronous reluctance motor rotor design

In this work a design methodology for synchronous reluctance motors (SynRM) is presented. The methodology is focused on maximizing the average torque but also takes into account the torque ripple. The presented methodology parameterizes the rotor in function of certain design variables which define the arrangement of the iron segments and flux barriers. The change in one of these design variables involves a change in the rotor geometry, resulting in a new machine design. The methodology is based in the systematically change of the design variables. The machine electromagnetic behavior and the performance of the motor is evaluated with finite elements models (FEM).
Levels of processing: the evolution of a framework

Although the levels of processing framework have evolved over its nearly 40 years of existence, the essence of the idea has not changed from the original. The original article published in 1972 suggests that in the encoding stage of a stimulus, there is a series of processing hierarchies ranging from the shallowest level (perceptual processing-the subject initially perceives the physical and sensory characteristics of the stimulus) to the deepest level (semantic processing-related to pattern recognition and extraction of meaning). The depth processing is associated with high levels of retention and long-term memory traces. After extensive research and criticism, the authors added several concepts that aided in a better understanding of levels of processing framework and the items that subjects can recall such as transfer-appropriate processing and robust encoding. However, there are still some gaps in this framework that call for new scientific investigations, ranging from experimental paradigms with lists of words with healthy or pathological conditions subject to neuroimaging studies to confirm, refute or improve the framework. The aim of this article is to review the publications (articles and book chapters) dating from the original article to the present day to better understand the mnemonic process in terms of levels of processing and to highlight some of its contributions.
A New Efficient E-Lottery Scheme Using Multi-Level Hash Chain

In this paper, a new fair and efficient electronic lottery (e-lottery) scheme is proposed. It utilizes a delaying function based on hash collision to generate the winning result of lottery, and to assure anonymity of lottery purchasers and to enable purchasers to participate in the generation of the winning result and verify the result. Meanwhile, a multi-level hash chain is used in the design of the scheme to reduce the computation for verifying the winning result. Only secure oneway hash functions are used in purchaser side, the computation and communication cost is low. The scheme proposed is suitable for lottery systems with many mobile users.
An Insight into Vowel Perception and Production by Children with Cochlear Implants and Children with Normal Hearing.

Speech perception and speech production are two related complex processes. The success of cochlear implant can be evaluated only by studying both the perception and production. The present study compares the perception and production of the phonologically significant contrasts (vowels) of the children with cochlear implants with those of age matched normal hearing children. The vowel perception scores are slightly poorer in children with cochlear implants when compared to normal hearing group. Vowel back ness (bell/ ball) was easy to be perceived than vowel height (pin/ pen and put/pot) fetching better scores. Significant difference was seen in formant values of vowels between both the groups. Significant difference in vowel duration between both the groups can be due to lack of adequate auditory feedback for rapid and smooth production of complex motoric sequences of speech. Significant difference in word duration between both the groups can be due to prolongation of vowel segments and insertion of several inter syllabic pauses.
Microbiota‐dependent metabolite trimethylamine‐N‐oxide is associated with disease severity and survival of patients with chronic heart failure

Recent metabolomic, experimental and clinical studies have demonstrated that trimethylamine‐N‐oxide (TMAO), a microbiota‐dependent metabolite from dietary phosphatidylcholine and carnitine, is a strong predictor of coronary artery disease (CAD). This finding suggests a link between the gut microbiota and atherosclerosis. The potential impact of TMAO in chronic heart failure (HF) is unknown. We hypothesized that TMAO levels would provide prognostic information about adverse outcomes in chronic HF.
Identifying the concepts contained in outcome measures of clinical trials on stroke using the International Classification of Functioning, Disability and Health as a reference.

OBJECTIVES To systematically identify and quantify the concepts contained in outcome measures in stroke trials using the International Classification of Functioning, Disability and Health (ICF) as a reference. METHODS Randomized controlled trials between 1992 and 2001 were located in MEDLINE and selected according to predefined criteria. Outcome measures were extracted and concepts contained in the outcome measures were linked to the ICF. RESULTS A random sample of 160 (50%) of 320 eligible studies was included. A total of 148 standardized health status measures were identified. Of 11,283 extracted concepts, 91% could be linked to the ICF. The most used ICF categories for each component were d450 walking (70%) for activities and participation, b525 defecation functions (62%) for body functions, and e399 support and relationships, unspecified (30%) for environmental factors. CONCLUSION The ICF provides a useful reference to identify and quantify the concepts contained in outcome measures used in stroke trials. Outcome measurement in stroke refers to an enormous variety of concepts; for comparability of research findings agreement on what should be measured is needed.
Separation and properties of the cytoplasmic and outer membranes of vegetative cells of Myxococcus xanthus

We have developed methods for separating the cytoplasmic and outer membranes of vegetative cells of Myxococcus xanthus. The total membrane fraction from ethylenediaminetetraacetic acid-lysozyme-treated cells was resolved into three major fractions by isopycnic density centrifugation. Between 85 and 90% of the succinate dehydrogenase and cyanide-sensitive reduced nicotinamide adenine dinucleotide oxidase activity was found in the first (I) fraction (rho = 1.221 g/ml) and 80% of the membrane-associated 2-keto-3-deoxyoctonate was found in the third (III) fraction (rho = 1.166 g/ml). The middle (II) fraction (rho = 1.185 g/ml) appeared to be a hybrid membrane fraction and contained roughly 10 to 20% of the activity of the enzyme markers and 2-keto-3-deoxyoctonate. No significant amounts of deoxyribonucleic acid or ribonucleic acid were present in the three isolated fractions, although 26% of the total cellular deoxyribonucleic acid and 3% of the total ribonucleic acid were recovered with the total membrane fraction. Phosphatidylethanolamine made up the bulk (60 to 70%) of the phospholipids in the membrane fractions. However, virtually all of the phosphatidylserine and cardiolipin were found in fraction I. Fraction III appeared to contain elevated amounts of lysophospholipids and contained almost three times the amount of total phospholipid as compared with fraction I. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis resolved approximately 40 polypeptides in the total membrane fraction. Two-thirds of these polypeptides were enriched in fraction I, and the remainder was enriched in fraction III. Fraction II contained a banding pattern similar to the total membrane fraction. Electron microscopy revealed that vegetative cells of M. xanthus possessed an envelope similar to that of other gram-negative bacteria; however, the vesicular appearance of the isolated membranes was somewhat different from those reported for Escherichia coli and Salmonella typhimurium. The atypically low bouyant density of the outer membrane of M. xanthus is discussed with regard to the high phospholipid content of the outer membrane.
Outcomes of Acid Suppressive Therapy in Patients with Posterior Laryngitis

OBJECTIVE: To evaluate the results of acid suppressive therapy (AST) in posterior laryngitis (PL) patients with and without documented pharyngeal acid reflux (PAR). METHODS: The charts of all patients with PL who received AST and who had undergone pharyngeal pH monitoring were reviewed. Results of AST in patients with PL with and without documented PAR were evaluated by laryngeal examination, symptom scores, and self-reported overall benefit. RESULTS: Thirty-nine patients with PL had received AST and undergone pharyngeal pH monitoring. Follow-up ranged from 2 to 27 months. Laryngeal findings were improved in patients with and without PAR. Pretreatment total symptom scores were significantly greater than that of posttreatment in patients with and without documented PAR. Overall benefit from AST was reported by the majority of PL patients with and without documented PAR. CONCLUSION: These findings support the use of AST to reduce or eliminate signs and symptoms in PL regardless of documentation of PAR. (Otolaryngol Head Neck Surg 2001;124:16-22.)
DRAM architecture for efficient data lifetime management

Many applications compute on sensitive data, such as confidential user information. Even if these applications are terminated, sensitive data often persist in the main memory indefinitely until the deallocated pages are overwritten by OS. The conventional software-only solution of zeroing pages at deallocation generates a significant amount of bursty memory traffic to slow down other processes running concurrently. To address this, we propose Secure DRAM, a novel DRAM architecture that enables low-cost, secure deallocation of physical page frames. By preventing access to unallocated DRAM pages and not refreshing them, Secure DRAM effectively closes the window of vulnerability with minimal performance overhead.
Comportamiento de los precios de las acciones en el mercado bursátil argentino (Un estudio comparativo)

Se estudio el comportamiento de los activos del mercado argentino en relacion al mercado estadounidense (probablemente el mas desarrollado del mundo en cuanto a legislacion, volumen y liquidez). Se llega a la conclusion de que los retornos de los activos no se distribuyen normamente. Para testear la presuncion de independencia se ha analizado la correlacion serial y se ha efectuado un test estadistico de corridas. Se concluye que los activos locales presentan cierta dependencia estadistica, la cual podria abrir cierta posibilidad de una renta extraordinaria. Para estudiar dicha posibilidad se ha implementado una estrategia teorica de “trading” que implica el uso de filtros. Para los activos nacionales efectivamente es posible obtener dicha renta, pero esta es eliminada cuando se incluyen comisiones. Por otro lado se testeo el modelo teorico conocido como “random walk”(RW) a traves de un test de cociente de varianzas. Finalmente se testea la existencia de memoria a largo plazo en las series a traves de un test R/S modificado.