Miracle-dz/UniFAR-FTUs huggingface dataset:
Microbiome Datasets Are Compositional: And This Is Not Optional

Datasets collected by high-throughput sequencing (HTS) of 16S rRNA gene amplimers, metagenomes or metatranscriptomes are commonplace and being used to study human disease states, ecological differences between sites, and the built environment. There is increasing awareness that microbiome datasets generated by HTS are compositional because they have an arbitrary total imposed by the instrument. However, many investigators are either unaware of this or assume specific properties of the compositional data. The purpose of this review is to alert investigators to the dangers inherent in ignoring the compositional nature of the data, and point out that HTS datasets derived from microbiome studies can and should be treated as compositions at all stages of analysis. We briefly introduce compositional data, illustrate the pathologies that occur when compositional data are analyzed inappropriately, and finally give guidance and point to resources and examples for the analysis of microbiome datasets using compositional data analysis.
Performance Investigation of a UWB Relay System using Multiple Relays with Multiple Antennas in IEEE 802.15.3a Channel

In order to coexist with existing legacy wireless systems, the transmit power spectral density (PSD) of ultra-wideband (UWB) impulse radio systems is limited. The coverage range of the UWB systems is then confined within a few meters. One possible way to achieve a greater coverage is a short-range multihop relaying strategy. This paper proposes a two-hop UWB relay system using multiple detect-and-forward relays, each of which is equipped with multiple antennas. Each multiple-antenna relay performs spatial diversity reception with partial-Rake scheme in the first hop, and decides whether or not to perform spatial transmit diversity with partial-pre-Rake scheme in the second hop. This leads not only to low complexity at the receiver, but also to reduced error propagation. Moreover, we derive the outage probability of the proposed relay system based on the IEEE 802.15. 3a channel model. The effects of using multiple relay antennas, relays, and Rake/pre-Rake fingers on the outage performance are demonstrated. The tradeoffs among the numbers of relay antennas, relays, and Rake/pre-Rake fingers are also investigated. Numerical results show that it is best to use multiple relay antennas to improve the outage performance of the proposed system. Furthermore, in general, increasing the number of relays is more beneficial than increasing the number of Rake/pre-Rake fingers.
Hypertension among 1000 patients with type 2 diabetes attending a national diabetes center in Jordan

BACKGROUND AND OBJECTIVES In Jordan, there is a paucity of research on hypertension and its risk factors among patients with type 2 diabetes mellitus. This study was designed to assess the prevalence of hypertension, risk factors, and the level of awareness and control of hypertension among outpatients with type 2 diabetes. SUBJECTS AND METHODS A cross-sectional study was carried out on a sample of 1000 patients with type 2 diabetes who were attending the National Center for Diabetes, Endocrine and Genetic Diseases for follow-up during the period of June to December 2006. Data were collected from medical records and through a structured interview questionnaire. Logistic regression analysis was used to assess the independent effect of variables on hypertension. RESULTS The prevalence of hypertension (BP >130/80 or on medication for high blood pressure) was 72.4% (70.9% of males and 73.9% of females). The logistic regression indicated that hypertension was positively associated with age (P=.001), body mass index (P=.001), and duration of diabetes (P=.001). About one-half of patients who were aware of having hypertension failed to keep their blood pressure under control. CONCLUSION Hypertension is a common co-morbidity among diabetic patients. Despite a high rate of awareness of hypertension among study subjects (93%), hypertension was not controlled to the recommended levels of blood pressure in about one-half (50.4%) of patients.
Epithelial damage and response.

Epithelial damage is a characteristic feature of asthma. The epithelium is not merely a passive barrier but can generate a range of mediators that may play a role in the inflammatory and remodelling responses that occur in the lungs in asthma. For example, the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF), whose principal source is the epithelium, can prolong eosinophil survival while transforming growth factor is a potent profibrogenic cytokine. Deposition of collagen in the epithelial subbasement membrane is a characteristic feature of the remodelling response in asthma. This may be due to abnormal associations between myofibroblasts and epithelium, both of which are involved in early lung development (epithelial-mesenchymal trophic unit). In asthma, there may be a primary defect in the epithelium such that it responds abnormally to various stimuli and cannot undergo the normal repair response. Epidermal growth factor (EGF) appears to be a key factor in bronchial epithelial repair; it stimulates epithelial cell proliferation and migration. The 3v isoform of the adhesion molecule CD44 is overexpressed in damaged epithelium and seems to regulate the repair response by presenting EGF more efficiently to its receptor. Although EGF receptor expression is increased in asthma, it does not lead to an appropriate proliferative response and restitution of normal epithelium. Other factors such as transforming growth factor (TGF)beta which are generated by inflammatory cells and epithelium are also upregulated in asthma. An epithelial/fibroblast co-culture system has shown that following epithelial damage various growth factors are released from the underlying myofibroblasts and are responsible for the proliferative response. The TGFbeta family are most likely responsible for collagen production. In an in vitro study, an EGF receptor inhibitor slowed epithelial repair but enhanced TGFbeta production by the slowly repairing epithelial cells. In conclusion, the interaction between epithelial cells and myofibroblasts, i.e. reactivation of the epithelial-mesenchymal trophic unit appears to be central to the airway wall remodelling response.
Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial

Transcranial Doppler (TCD) With Transfusions Changing to Hydroxyurea (TWiTCH) trial is a randomized, open‐label comparison of hydroxycarbamide (also termed hydroxyurea) versus continued chronic transfusion therapy for primary stroke prevention in patients with sickle cell anaemia (SCA) and abnormal TCD. Severity and location of iron overload is an important secondary outcome measure. We report the baseline findings of abdominal organ iron burden in 121 participants. At enrollment, patients were young (9·8 ± 2·9 years), predominantly female (60:40), and previously treated with transfusions (4·1 ± 2·4 years) and iron chelation (3·1 ± 2·1 years). Liver iron concentration (LIC; 9·0 ± 6·6 mg/g dry weight) and serum ferritin were moderately elevated (2696 ± 1678 μg/l), but transferrin was incompletely saturated (47·2 ± 23·6%). Spleen R2* was 509 ± 399 Hz (splenic iron ~13·9 mg/g) and correlated with LIC (r2 = 0·14, P = 0·0008). Pancreas R2* was increased in 38·3% of patients but not to levels associated with endocrine toxicity. Kidney R2* was increased in 80·7% of patients; renal iron correlated with markers of intravascular haemolysis and was elevated in patients with increased urine albumin‐creatinine ratios. Extra‐hepatic iron deposition is common among children with SCA who receive chronic transfusions, and could potentiate oxidative stress caused by reperfusion injury and decellularized haemoglobin.
Patient Perception , Preference and Participation Psychiatric patients ’ preferences and experiences in clinical decision-making : Examining concordance and correlates of patients ’ preferences

Objective: To assess the concordance between patients’ preferred role in clinical decision-making and the role they usually experience in their psychiatric consultations and to analyze the influence of sociodemographic, clinical and personality characteristics on patients’ preferences. Methods: 677 consecutive psychiatric outpatients were invited to participate in a cross-sectional survey and 507 accepted. Patients completed Control Preference Scale twice consecutively before consultation, one for their preferences of participation and another for the style they usually experienced until then, and locus of control and self-efficacy scales. Results: Sixty-three percent of psychiatric outpatients preferred a collaborative role in decision-making, 35% preferred a passive role and only a 2% an active one. A low concordance for preferred and experienced participation in medical decision-making was registered, with more than a half of patients wanting a more active role than they actually had. Age and doctors’ health locus of control orientation were found to be the best correlates for participation preferences, while age and gender were for experienced. Psychiatric diagnoses registered significant differences in patients’ preferences of participation but no concerning experiences. Conclusion: The limited concordance between preferred and experienced roles in psychiatric patients is indicative that clinicians need to raise their sensitivity regarding patient’s participation. Practice Implications: The assessment of patient’s attribution style should be useful for psychiatrist to set objectives and priority in the communication with their patients. 2014 Elsevier Ireland Ltd. All rights reserved.
LncRNA DANCR promotes migration and invasion through suppression of lncRNA-LET in gastric cancer cells

Gastric cancer (GC) is one of the most prevalent gastrointestinal malignancies. Long noncoding RNA (lncRNA) DANCR is a newly identified oncogenic lncRNA. However, the functional role and underlying molecular mechanisms of DANCR involved in GC progress remain unclear. In the present study, we investigated the biological function and underlying mechanisms of DANCR in GC cell migration and invasion. The results showed that knockdown of DANCR inhibited migration and invasion of GC cells, whereas overexpression of DANCR showed the opposite effect. Further investigation demonstrated that lncRNA-LET was a bona fide target gene of DANCR. In addition, high DANCR and low lncRNA-LET were significantly correlated with lymph node metastasis and late clinical stage. DANCR associated with EZH2 and HDAC3 to epigenetically silence lncRNA-LET and then regulated GC migration and invasion. Taken together, these findings indicate an important role for DANCR–lncRNA-LET axis in GC cell migration and invasion, and reveal a novel epigenetic mechanism for lncRNA-LET silencing.
Appropriate Delivery of Advice and Guidance on Method Adaptation

One can find enough evidence in the IS development (ISD) literature supporting the significance of method adaptation for the realization of an effective ISD. Method adaptation involves a decision making process through which the agent(s) modifies the project situation, including the method and the project context, at hand. This paper aims at exploring how a better delivery of guidance and advice (decision support) on method adaptation, i.e. the degree of which the decision support to be provided is employed successfully, can be achieved. To do this we study several stages in which a set of advice and guidance with some decision support tools on method adaptation realized in a large-scale IT department. Each stage is distinguished with respect to the underlying discourses proposed in the decision support literature and elaborated in terms of the method used, the involved parties concerning method adaptation, and the means used in a ten-year timeline in the department. This study shows that agility of the method used, the degree of sharedness of the meaning of method adaptation held by involved parties, the decision support approach (top-down, bottom-up, or middle-out approaches reflecting the degree of dominations of involved parties) to method adaptation, and the combination of humanand technology-driven guidance are essential to an appropriate delivery of decision support for method adaptation.
The Increasing Financialization of China’s Urbanization

This paper provides a heuristic framework to address issues about China’s ongoing urbanization in relation to the role of land and built environment as triggers for economic growth and to the increasing financialization of urban production. While a dominant field of literature highlights the interrelation between land and capital within a specific institutional setting between Central and local governments, it argues to include other key linkages between infrastructures, property development and finance to understand China’s recent exponential urban growth. It first places the current consequent local governments’ debt into perspective along with the evolution of financial circuits for urban infrastructures resulting from Central Government policy and regulation changes. Next, and in line with the real estate literature that highlights the key role of demand, it develops an original understanding of the financialization of urban production from the perspective of China’s property industry. Besides the role of homeownership policies since 1998 which boosted urban production based on use value, various ways of the transformation of property into financial assets have occurred. Chinese households as the main investors have not only been able to directly invest in housing and in non-housing by purchasing flats or commercial property but indirectly by increasing investments in special purpose vehicles such as trust-bank and funds finance and new kinds of investment platforms. In both cases, Central Government macropolicies, both stimulating and restricting from 2008–2016, have gone in hand with increasing financialization processes for local governments’ debt, urban infrastructure financing and real estate.
Human Leukocyte Antigen-G (HLA-G) Expression in Cancers: Roles in Immune Evasion, Metastasis and Target for Therapy

Aberrant induction of human leukocyte antigen-G (HLA-G) expression has been observed in various malignancies and is strongly associated with tumor immune escape, metastasis and poor prognosis. To date, great achievements have been made in understanding the underlying mechanisms of HLA-G involved in tumor progression. HLA-G could lead to tumor evasion by inhibition of immune cell cytolysis, differentiation and proliferation and inhibition of cytokine production, induction of immune cell apoptosis, generation of regulatory cells and expansion of myeloid-derived suppressive cells and by impairment of chemotaxis. Moreover, HLA-G could arm tumor cells with a higher invasive and metastatic potential with the upregulation of tumor-promoting factor expression such as matrix metalloproteinases (MMPs), indicating that ectopic HLA-G expression could render multiple effects during the progression of malignancies. In this review, we summarized the mechanisms of HLA-G involved in promoting tumor cell immune escaping, metastasis and disease progression. Special attention will be paid to its significance as an attractive therapeutic target in cancers.
A Hybrid Current-Limiting Circuit for DC Line Fault in Multiterminal VSC-HVDC System

The high fault current of dc line is a major threat to multiterminal voltage-source-converter-based HVDC (VSC-HVDC) system. However, dc circuit breaker (DCCB) with large capacity and fast breaking speed is still under development. Therefore, fault current limitation is vital for the multiterminal VSC-HV DC system. This paper proposes a simple and easily applied hybrid current-limiting circuit (HCLC) at dc side, which consists of a current-limiting inductor (CLI) and an energy dissipation circuit (EDC) in parallel with the CLI. The CLI is designed to reduce the requirement for the DCCB's capacity and breaking speed. The EDC, which consists of thyristor-controlled resistors, is proposed to reduce the stress on energy absorption element (metal oxide arrester) in DCCB and to accelerate the fault current interruption. The design and discussion about the HCLC parameters are performed in detail. By employing the proposed HCLC, dc line fault in the multiterminal system can be isolated effectively with existing DCCB technology, and fast system restoration without power interruption of healthy part can be achieved. Numerous simulations with real-time digital simulator and comparisons with traditional schemes have demonstrated the promising performance of the proposed HCLC. The effectiveness of the HCLC's topology has also been verified by a simplified and scaled test circuit.
Safety reporting in randomized trials of mental health interventions.

OBJECTIVE The authors aimed to evaluate the adequacy of the reporting of safety information in publications of randomized trials of mental-health-related interventions. METHOD The authors randomly selected 200 entries from the PsiTri registry of mental-health-related controlled trials. This yielded 142 randomized trials that were analyzed for adequacy and relative emphasis of their content on safety issues. They examined drug trials as well as trials of other types of interventions. RESULTS Across the 142 eligible trials, 103 involved drugs. Twenty-five of the 142 trials had at least 100 randomly chosen subjects and at least 50 subjects in a study arm. Among drug trials, only 21.4% had adequate reporting of clinical adverse events, and only 16.5% had adequate reporting of laboratory-determined toxicity, while 32.0% reported both the numbers and the reasons for withdrawals due to toxicity in each arm. On average, drug trials devoted 1/10 of a page in their results sections to safety, and 58.3% devoted more space to the names and affiliations of authors than to safety. None of the trials of nondrug interventions had adequate or even partially adequate reporting of either clinical adverse events or laboratory-determined toxicity. In multivariate modeling, long-term trials and trials conducted in the United States devoted even less space to safety, while schizophrenia trials devoted more space to safety than did trials in other areas. CONCLUSIONS Safety reporting is largely neglected across trials of mental-health-related interventions, thus hindering the assessment of risk-benefit ratios for rational decision making in mental health care.
Ultra thin low profile U band folded meta-material wideband dipole antenna for multi-Gb/s data transmission using 65 nm CMOS technology

A 60 GHz ultra thin low profile folded wideband dipole antenna on a metamaterial structured surface cavity for multi-Gb/s data transmission was proposed. To increase the radiation efficiency, meta-material resonant cavity was constructed to act as a reflector. Full wave electromagnetic simulation results reveal that a 4.6 dB gain and 7 GHz bandwidth were obtained at the center frequency of 60 GHz. The antenna substrate is only 10 μm thick, which is 98% reduction in substrate thickness in comparison with conventional conducting metal cavity antenna having the same gain and bandwidth. The significance of this work is that such low profile antenna can be fully integrated with standard silicon CMOS technology to make low cost wireless data transmission at U band.
What Makes Party Systems Different? A Principal Component Analysis of 17 Advanced Democracies 1970–2013

Abstract Party systems, that is, the number and the size of all the parties within a country, can vary greatly across countries. I conduct a principal component analysis on a party seat share dataset of 17 advanced democracies from 1970 to 2013 to reduce the dimensionality of the data. I find that the most important dimensions that differentiate party systems are: “the size of the biggest two parties” and the level of “competition between the two biggest parties. ” I use the results to compare the changes in electoral and legislative party systems. I also juxtapose the results to previous party system typologies and party system size measures. I find that typologies sort countries into categories based on variation along both dimensions. On the other hand, most of the current political science literature use measures (e.g., the effective number of parties) that are correlated with the first dimension. I suggest that instead of these, indices that measure the opposition structure and competition could be used to explore problems pertaining to the competitiveness of the party systems.
The Impact of Removing Selective Migration Restrictions on Education

An open question in migration research is how the removal of selective migration restrictions affects migrants’ education decisions. I analyze this question in the Chinese context, in which the household registration system imposes selective rural–urban migration restrictions. The identification derives from a policy change that grants urban residency to a group of rural individuals based on their dates of birth. Using a regression discontinuity approach, I find that educational attainments for barely eligible rural residents decreased sharply after the reform. These effects are larger for males and for those able to permanently migrate to relatively rich areas.
The Power of a Bad Example - A Field Experiment in Household Garbage Disposal

Field-experimental studies have shown that people litter more in more littered environments. Inspired by these findings, many cities around the world have adopted policies to quickly remove litter. While such policies may prevent people from following the bad example of litterers, they may also invite free-riding on public cleaning services. We are the first to show that both forces are at play. We conduct a natural field experiment where, in a randomly assigned part of a residential area, the frequency of cleaning was drastically reduced during a three-month period. We find evidence that some people start to clean up after themselves when public cleaning services are diminished. However, the tendency to litter more dominates. We also find that these responses continue to exist for some time after the treatment has ended.
The 9p21 coronary artery disease locus and kidney dysfunction in patients with Type 2 diabetes mellitus.

BACKGROUND We investigated whether the coronary artery disease (CAD) locus on chromosome 9p21 (as represented by single nucleotide polymorphism rs2383206) is associated with low estimated glomerular filtration rate (eGFR) or increased urinary albumin excretion in patients with Type 2 diabetes mellitus (T2DM). METHODS Four samples, including a total of 3167 patients, were studied. The presence of low eGFR (<60 mL/min/1.73m(2)) was estimated from serum creatinine by means of the Modification of Diet in Renal Disease Study equation. Increased urinary albumin excretion was defined as an albumin-creatinine ratio (ACR) ≥2.5 mg/mmol in men and ≥3.5 mg/mmol in women. RESULTS No association was found between rs2383206 and low eGFR or increased ACR in each sample as well as in a pooled analysis (overall odds ratio = 1.07, 95% confidence interval 0.94-1.22, P = 0.31 and overall odds ratio = 1.00, 95% confidence interval 0.90-1.12, P = 0.95, respectively). No interaction was observed between rs2383206 and poor glycemic control [HbA1c was above the median in the pooled sample (7.7%) in modulating eGFR or ACR (P for interaction = 0.42 and 0.90, respectively)]. CONCLUSION Variability at the 9p21 CAD locus is unlikely to play a role in modulating susceptibility to kidney dysfunction in patients with T2DM.