Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling kinetic partitioning of secondary organic aerosol and size distribution dynamics: representing effects of volatility, phase state, and particle-phase reaction

This paper describes and evaluates a new framework for modeling kinetic gas-particle partitioning of secondary organic aerosol (SOA) that takes into account diffusion and chemical reaction within the particle phase. The framework uses a combination of (a) an analytical quasi-steady-state treatment for the diffusion–reaction process within the particle phase for fast-reacting organic solutes, and (b) a two-film theory approach for slow- and nonreacting solutes. The framework is amenable for use in regional and global atmospheric models, although it currently awaits specification of the various gas- and particle-phase chemistries and the related physicochemical properties that are important for SOA formation. Here, the new framework is implemented in the computationally efficient Model for Simulating Aerosol Interactions and Chemistry (MOSAIC) to investigate the competitive growth dynamics of the Aitken and accumulation mode particles. Results show that the timescale of SOA partitioning and the associated size distribution dynamics depend on the complex interplay between organic solute volatility, particle-phase bulk diffusivity, and particle-phase reactivity (as exemplified by a pseudo-first-order reaction rate constant), each of which can vary over several orders of magnitude. In general, the timescale of SOA partitioning increases with increase in volatility and decrease in bulk diffusivity and rate constant. At the same time, the shape of the aerosol size distribution displays appreciable narrowing with decrease in volatility and bulk diffusivity and increase in rate constant. A proper representation of these physicochemical processes and parameters is needed in the next generation models to reliably predict not only the total SOA mass, but also its composition- and number-diameter distributions, all of which together determine the overall optical and cloud-nucleating properties.
Effects of Active Immunization with a Pneumococcal Surface Protein (PspA) and of Locally Applied Antibodies in Experimental Otitis media

An experimental rat model for Streptococcus pneumoniae otitis media was used to investigate passive protection by anti-type 3 capsular antibodies and effects of immunization with pneumococcal surface protein A (PspA). Anti-type 3 antibodies instilled into the middle ear reduced purulent otitis media as compared to control animals (p = 0.015). Secondly, after immunization with PspA, the right middle ear was inoculated with S. pneumoniae type 6A in a dose calibrated to induce purulent otitis media. There was an anti-PspA antibody response in all rats immunized and a reduction in signs of purulent otitis media as compared to control animals (p = 0.026). Thus, purulent (acute) otitis media can be reduced by local application of antibodies in the middle ear and also by immunization with a non-type-specific pneumococcal protein, PspA.
Cultured porcine trabecular meshwork cells display altered lysosomal function when subjected to chronic oxidative stress.

PURPOSE To investigate the effects of chronic oxidative stress on lysosomal function in trabecular meshwork (TM) cells. METHODS Confluent cultures of porcine TM cells were grown for 2 weeks in physiological (5% O(2)) or hyperoxic conditions (40% O(2)) in the presence or absence of the protease inhibitor leupeptin (10 microM). The following parameters were quantified using the fluorogenic probes indicated within parentheses: autofluorescence, intracellular reactive oxygen species (ROS; H(2)DCFDA), mitochondrial membrane potential (JC-1), mitochondrial content (Mitotracker Red; Invitrogen-Molecular Probes, Eugene, OR), lysosomal content (acridine orange and Lysotracker Red [Invitrogen-Molecular Probes]), autophagic vacuole content (MDC), SA-beta-galactosidase (FDG), and cathepsin activities (z-FR-AMC). Cathepsin levels were quantified by qPCR and Western blot analysis. Ultrastructural analysis was performed by transmission electron microscopy. RESULTS Prolonged exposure of porcine TM cells to a hyperoxic environment led to an increase in ROS production and oxidized material. Electron micrographs revealed the cytoplasmic accumulation of lipofuscin-loaded lysosomes. Augmented lysosomal and autophagic vacuole content was confirmed with specific fluorophores. The mRNA and protein levels of several cathepsins were upregulated with oxidative stress. This upregulated expression did not correlate with increased lysosomal activity. CONCLUSIONS The results indicate that chronic exposure of TM cells to oxidative stress causes the accumulation of nondegradable material within the lysosomal compartment, leading to diminished lysosomal activity. Since the lysosomal system is responsible for the continuous turnover of cellular organelles, impaired lysosomal activity may lead to progressive failure of cellular TM function with age.
Variación genética y patogénica de Fusarium oxysporum f. sp. dianthi en España

Con el fin de profundizar en el conocimiento de la variabilidad de Fusarium oxysporum f. sp. dianthi en Espana, se realizo un estudio de un total de 53 aislados de este hongo, colectados en Galicia y el Sureste, junto con un grupo de ocho cepas de referencia. Se caracterizo la raza de cada aislado mediante la reaccion de patogeneicidad en hospedantes diferenciales, y se determinaron sus grupos de compatibilidad vegetativa y sus pautas de amplificacion mediante RAPD-PCR. De los 53 aislados, 49 fueron patogenicos, perteneciendo 46 a la raza 2, dos a la raza 4 y uno a la raza 1. Este gran predominio de la raza 2 es similar al observado en otros paises. Todos los aislados de la misma raza, pertenecieron al mismo VCG y presentaron una pauta RAPD-PCR muy similar. Tres aislados no patogenicos del Sureste, presentaron cada uno un VCG y una pauta RAPD-PCR especifica. La gran consistencia de los datos de VCGs y RAPD-PCR con la reaccion de patogeneicidad de F. o. dianthi, pone de manifiesto el interes de estos metodos para una determinacion rapida de determinadas razas de este hongo.
Contagion of deliberate self-harm among adolescent inpatients.

OBJECTIVE To explore the quantitative importance and clinical features of deliberate self-harm (DSH) contagion in a closed adolescent psychiatric unit. METHOD The authors investigated with statistical methods and a sociogram whether acts of DSH were clustered during a 12-month study period. Twelve subjects were involved in acts of DSH, and their mean length of hospitalization during the study period was about 90 days. Six adolescents with four or more contagion incidents were interviewed. RESULTS DSH incidents were clustered during the study period (p < .05). Most DSH incidents were skin cutting committed by depressed female subjects with borderline personality disorder. The majority of DSH contagion can be understood in terms of small-group rites for feelings of togetherness. CONCLUSIONS Even a majority of DSH events in closed adolescent units may be triggered by contagion, and DSH can spread to previously DSH-naive adolescents.
High School Dropout Determinants: The Effect of Socioeconomic Status and Learning Disabilities

Considering the growing importance ofhigher education due to increased global competition, one might wonder why some students still opt to drop out ofhigh school. Previous literature has focused on a number of determinants ofhigh school dropouts, such as socioeconomic status and learning disabilities. However, this literature has not systematically explored the interaction between these two variables. Therefore, my research extends past literature by focusing on this interaction. A logit model is used to predict the dichotomous variable, high school dropouts, and to run simulations with varying values of the independent variables. The results show that low socioeconomic status, learning disabilities, and most importantly the interaction between these two variables increase the likelihood of dropping out ofhigh school for students facing these challenges.
Compact InGaAsP/InP Asymmetric Mach–Zehnder Coupled Square Ring Modulator

We propose a compact InGaAsP/InP electro-optic ring modulator operated with coupling modulation that can circumvent the bandwidth limitation and large minimum bend radius of a ring. This device consists of frustrated total internal reflection (TIR) couplers and TIR mirrors serving as 90° waveguide bends, forming the configuration of an asymmetric rectangular Mach–Zehnder interferometer coupled to a square ring resonator (SRR). A discrete-time dynamic model and finite-difference time-domain method are used to evaluate the device performances, and the theoretical results show an operating frequency up to 60 GHz, the maximum extinction ratio of ~12 dB, the low electrical energy of ~60 fJ/bit, and a compact chip size of $\sim 18~\mu \text{m} \,\, \times 29~\mu \text{m}$ , respectively. The enabling component of the SRR represents >100-fold footprint reduction on a chip. This compact device can be potentially applied in large-scale InP-based photonic integrated circuits.
Randomized trial of valganciclovir versus valacyclovir prophylaxis for prevention of cytomegalovirus in renal transplantation.

BACKGROUND AND OBJECTIVES Both valganciclovir and high-dose valacyclovir are recommended for cytomegalovirus prophylaxis after renal transplantation. A head-to-head comparison of both regimens is lacking. The objective of the study was to compare valacyclovir prophylaxis with valganciclovir, which constituted the control group. DESIGN, SETTINGS, PARTICIPANTS, & MEASUREMENTS In a randomized, open-label, single-center trial, recipients of renal transplants (recipient or donor cytomegalovirus-seropositive) were randomly allocated (1:1) to 3-month prophylaxis with valacyclovir (2 g four times daily) or valganciclovir (900 mg daily). Enrollment occurred from November of 2007 to April of 2012. The primary end points were cytomegalovirus DNAemia and biopsy-proven acute rejection at 12 months. Analysis was by intention to treat. RESULTS In total, 119 patients were assigned to valacyclovir (n=59) or valganciclovir prophylaxis (n=60). Cytomegalovirus DNAemia developed in 24 (43%) of 59 patients in the valacyclovir group and 18 (31%) of 60 patients in the valganciclovir group (adjusted hazard ratio, 1.35; 95% confidence interval, 0.71 to 2.54; P=0.36). The incidence of cytomegalovirus disease was 2% with valacyclovir and 5% with valganciclovir prophylaxis (adjusted hazard ratio, 0.21; 95% confidence interval, 0.01 to 5.90; P=0.36). Significantly more patients with valacyclovir prophylaxis developed biopsy-proven acute rejection (18 of 59 [31%] versus 10 of 60 [17%]; adjusted hazard ratio, 2.49; 95% confidence interval, 1.09 to 5.65; P=0.03). The incidence of polyomavirus viremia was higher in the valganciclovir group (18% versus 36%; adjusted hazard ratio, 0.43; 95% confidence interval, 0.19 to 0.96; P=0.04). CONCLUSIONS Valganciclovir shows no superior efficacy in cytomegalovirus DNAemia prevention compared with valacyclovir prophylaxis. However, the risk of biopsy-proven acute rejection is higher with valacyclovir.
A Fuzzy-Neural Fluctuation Smoothing Rule for Scheduling Jobs with Various Priorities in a semiconductor Manufacturing Factory

A fuzzy-neural fluctuation smoothing rule is proposed in this study to improve the performance of scheduling jobs with various priorities in a semiconductor manufacturing factory. The fuzzy-neural fluctuation smoothing rule is modified from the well-known fluctuation smoothing rule by improving the accuracy of estimating the remaining cycle time of a job, which is done by applying Chen's fuzzy-neural approach with multiple buckets. To evaluate the effectiveness of the proposed methodology, production simulation is also applied in this study. According to experimental results, incorporating a more accurate remaining cycle time estimation mechanism did improve the scheduling performance especially in reducing the average cycle times. Besides, the fuzzy-neural fluctuation smoothing rule was also shown to be a Pareto optimal solution for scheduling jobs with various priorities in a semiconductor manufacturing factory.
Environment Determines Fidelity for an RNA Virus Replicase

ABSTRACT The rate of insertion and deletion mutations of the replicase of Cucumber mosaic virus (CMV) was determined in planta by using a parasitic satellite RNA (satRNA) as a reporter. We found that the CMV replicase had different fidelity in different environments, with important implications in viral disease evolution. Insertions were very rare events, irrespective of the region of the satRNA genome assayed and independent of the hosts tested. On the other hand, deletion events were more frequent but were restricted to a highly structured region of the reporter. Deletion mutation rates were different for the two hosts tested, although the mutation distribution was not influenced by the hosts. Moreover, hot spots with high mutation rates were identified on the satRNA genome.
Perceptions of hypertension and contributing personal and environmental factors among rural Southern African American women.

OBJECTIVE This study aimed to describe the perceptions of Southern, rural, African American women regarding personal and environmental factors that affect their hypertension. DESIGN A purposive sample of 25 African American women aged 40-74 years, who lived in rural Alabama, participated in seven Talking Circles for 60 minutes. RESULTS Most felt that hypertension was a "common occurrence" and that it was "typical in the African American community. " They associated hypertension with stroke and heart attacks and referred to hypertension as the "silent killer. " Barriers to following the treatment plan were low income, high medical expenses, and lack of insurance. Barriers to medication were cost, dislike for taking medication, running out of medication, side effects, forgetting, and being tired; and barriers to exercise were being tired, busy schedule, and safety. Walking paths, fitness centers, or malls to walk around were not available in all communities, and not all sidewalks were well-lit, limiting their walking exercise opportunities after work hours. Healthcare facilities were accessible, but it was easier to get an appointment and receive respect from healthcare providers if the women had money or insurance. Blood pressure monitors were available in their homes, at grocery stores and at Wal-Mart. No church health programs were available, but some churches had nurses on duty who offered blood pressure and cholesterol screening; however, no medication was provided. Grocery stores were accessible, and they had a flea market with fresh fruits and vegetables. Social environment/support by families and friends for persons with hypertension was not always positive. CONCLUSION The findings of this study indicate that personal and environmental factors play important roles in hypertensive status. The modified ecological framework used in this study may help us explore perspectives of family members and friends regarding their support for persons with hypertension. More serious efforts and resources need to be made available for preventive measures of hypertension in this population.
Gender-specific association of perceived stress and inhibited breathing pattern

Stress can potentiate the development of hypertension via inhibition of renal excretory function. One potential mediating mechanism is an inhibited breathing pattern, because hypoventilation can decrease renal sodium excretion acutely via effects on pCO2 and acid-base balance. Large individual differences in resting breathing patterns have beenwell-documented, with some individuals maintaining slow frequency and high pCO2. Whether this breathing pattern is related to chronic stress has not been investigated. This study reports that high perceived stress over the past month was associated with significantly lower frequency breathing at rest, independently of age, race, or body mass index. This finding was more marked in women thaninmen. Inaddition, slow breathing frequency was independently associated with higher resting end tidal CO2 in both men and women. This is the first known reportofan association of sustained stress with an inhibited breathing pattern in humans, and points to a pathway by which chronic stress might contribute to the development of hypertension, especially in women.
GeneAnalytics Pathway Analysis and Genetic Overlap among Autism Spectrum Disorder, Bipolar Disorder and Schizophrenia

Bipolar disorder (BPD) and schizophrenia (SCH) show similar neuropsychiatric behavioral disturbances, including impaired social interaction and communication, seen in autism spectrum disorder (ASD) with multiple overlapping genetic and environmental influences implicated in risk and course of illness. GeneAnalytics software was used for pathway analysis and genetic profiling to characterize common susceptibility genes obtained from published lists for ASD (792 genes), BPD (290 genes) and SCH (560 genes). Rank scores were derived from the number and nature of overlapping genes, gene-disease association, tissue specificity and gene functions subdivided into categories (e.g., diseases, tissues or functional pathways). Twenty-three genes were common to all three disorders and mapped to nine biological Superpathways including Circadian entrainment (10 genes, score = 37.0), Amphetamine addiction (five genes, score = 24.2), and Sudden infant death syndrome (six genes, score = 24.1). Brain tissues included the medulla oblongata (11 genes, score = 2.1), thalamus (10 genes, score = 2.0) and hypothalamus (nine genes, score = 2.0) with six common genes (BDNF, DRD2, CHRNA7, HTR2A, SLC6A3, and TPH2). Overlapping genes impacted dopamine and serotonin homeostasis and signal transduction pathways, impacting mood, behavior and physical activity level. Converging effects on pathways governing circadian rhythms support a core etiological relationship between neuropsychiatric illnesses and sleep disruption with hypoxia and central brain stem dysfunction.
A simultaneous confidence corridor for varying coefficient regression with sparse functional data

We consider a varying coefficient regression model for sparse functional data, with time varying response variable depending linearly on some time-independent covariates with coefficients as functions of time-dependent covariates. Based on spline smoothing, we propose data-driven simultaneous confidence corridors for the coefficient functions with asymptotically correct confidence level. Such confidence corridors are useful benchmarks for statistical inference on the global shapes of coefficient functions under any hypotheses. Simulation experiments corroborate with the theoretical results. An example in CD4/HIV study is used to illustrate how inference is made with computable p values on the effects of smoking, pre-infection CD4 cell percentage and age on the CD4 cell percentage of HIV infected patients under treatment.
Inflammatory ringworm with unusual features

Zoophilic dermatophyte infections are often inflammatory but severe widespread inflammatory lesions of glabrous skin, as in the female patient described, are unusual. Most cases of M. canis ringworm can be traced to an infected animal. This dermatophyte is associated with a variety of clinical presentations on glabrous skin and is being isolated with increasing frequency in some countries.
Trace Mineral Nutrition in Poultry and Swine

Trace minerals such as zinc, copper, and manganese are essential cofactors for hundreds of cellular enzymes and transcription factors in all animal species, and thus participate in a wide variety of biochemical processes. Immune development and transcription factors in all animal species, and thus participate in a wide variety of biochemical processes. Immune development and response, tissue and bone development and integrity, protection against oxidative stress, and cellular growth and division are just a few examples. Deficiencies in trace minerals can lead to deficits in any of these processes, as well as reductions in growth performance. As such, most animal diets are supplemented with inorganic and/or organic forms of trace minerals. Inorganic trace minerals (ITM) such as sulfates and oxides form the bulk of trace mineral supplementation, but these forms of minerals are well known to be prone to dietary antagonisms. Feeding high-quality chelated trace minerals or other classes of organic trace minerals (OTM) can provide the animal with more bioavailable forms of the minerals. Interestingly, many, if not most, published experiments show little or no difference in the bioavailability of OTMs versus ITMs. In some cases, it appears that there truly is no difference. However, real differences in bioavailability can be masked if source comparisons are not made on the linear portion of the dose-response curve. When highly bioavailable chelated minerals are fed, they will better supply the biochemical systems of the cells of the animal, leading to a wide variety of benefits in both poultry and swine. Indeed, the use of certain chelated trace minerals has been shown to enhance mineral uptake, and improve the immune response, oxidative stress management, and tissue and bone development and strength. Furthermore, the higher bioavailability of these trace minerals allows the producer to achieve similar or improved performance, at reduced levels of trace mineral inclusion.
The relationship between the pubo‐urethral ligaments and the urogenital diaphragm in the human female

The connective tissue supports of the human female urethra have been investigated in 14 cadavers and 20 fetuses. In all cases the urethra was found to be suspended from the pubic bone by bilaterally symmetrical anterior, posterior and intermediate pubo‐urethral ligaments. The anterior and posterior ligaments were formed by reflections of the inferior and superior fascial layers of the urogenital diaphragm. The intermediate ligament represented a fusion of these fascial layers and no transverse perineal ligament was found.
Conformational Changes Required in the Human Growth Hormone Receptor for Growth Hormone Signaling*

Growth hormone (GH) plays a significant role in normal growth and development. Signaling to the cell is believed to require growth hormone receptor (GHR) dimerization, which occurs following binding of a single growth hormone molecule to each of two receptors. We have developed human growth hormone receptor-specific monoclonal antibodies, one of which was used here to characterize hormone/receptor interactions. This antibody, GHR05, is directed against the hinge spanning subdomains I and II of the receptor's extracellular region. Antibody binding to the cell surface receptor increases upon receptor binding to growth hormone, but not when it binds a mutant form, hGHG120R, which does not trigger receptor activation. Growth hormone binding thus appears to lead to a conformational change in the receptor epitope recognized by GHR05, giving rise to the active dimer configuration, necessary for signal transduction. Using a chimeric receptor-expressing, growth hormone-dependent murine cell line, we find that GHR05 binds to the receptor in the absence of human GH and delivers a signal leading to cell proliferation. Finally, GHR05 treatment of IM-9 cells, a human cell line expressing a functional human GHR, leads to cell proliferation mediated by the generation of GH-specific signals, including phosphorylation of the JAK2 tyrosine kinase and activation of STAT5.