Miracle-dz/UniFAR-FTUs huggingface dataset:
Synthesizing Non Photo-Realistic Rendering Effects of Volumetric Strokes

NPR (Non Photo-Realistic Rendering) is an important issue in Computer Graphics. It presents a totally different style from those using realistic methods. In this paper we take advantage of a 3D NPR system in color presentation, and apply stroke merging and sketch-based modeling to synthesize NPR images with volumetric effects, such as oil painting, bas-relief sculpture, and clay relief. To represent these volumetric visual effects on canvas we adopt a mesh generation method which generates the thickness of strokes. By controlling the ratio of height and width to the base area, the surface curvature is adjusted to reflect the shape differences between impasto oil painting and clay relief. Then a mesh smoothing method is applied to each group of strokes. In addition, users can personalize their own color palette by using keywords such as the name of the artist, or by choosing color sets through our GUI which categorizes color space into an emotional map. Users choose by using keywords, then related images are gathered from online resources using web-mining technology, and the appropriate colors are extracted to construct a color chart by analyzing the images. Then, the color chart is used to control the distribution of colors on the canvas. As shown in the experiment results, our 3D NPR system creates interesting and vivid images of oil painting and clay relief works. Finally, we integrate our volumetric NPR image with a relief mapping technique to provide real-time interaction.
Variation in use of high-cost diabetes mellitus medications in the VA healthcare system.

1. Iglehart JK. Health insurers and medical-imaging policy—a work in progress. N Engl J Med. 2009;360(10):1030-1037. 2. Redberg RF. Cancer risks and radiation exposure from computed tomographic scans: how can we be sure that the benefits outweigh the risks? Arch Intern Med. 2009;169(22):2049-2050. 3. Stern RG. Diagnostic imaging: powerful, indispensable, and out of control. Am J Med. 2012;125(2):113-114. 4. Brook RH. Do physicians need a “shopping cart” for health care services? JAMA. 2012;307(8):791-792. 5. Cooke M. Cost consciousness in patient care—what is medical education’s responsibility? N Engl J Med. 2010;362(14):1253-1255. 6. Weinberger SE. Educating trainees about appropriate and cost-conscious diagnostic testing. Acad Med. 2011;86(11):1352. 7. American Board of Internal Medicine. Choosing Wisely Initiative. http://www . abimfoundation.org/Initiatives/Choosing-Wisely.aspx. Accessed July 22, 2012. 8. Porter ME. What is value in health care? N Engl J Med. 2010;363(26):2477-2481. 9. McMahon LF Jr, Chopra V. Health care cost and value: the way forward. JAMA. 2012;307(7):671-672.
Reducing risk by raising HDL-cholesterol: the evidence

Low HDL-cholesterol is common among patients with cardiovascular disease. Well-designed epidemiological studies carried out over the previous three decades have defined the prognostic significance of low HDL-cholesterol. Indeed, a recent evaluation of patients undergoing coronary angiography showed that factors related to HDL-cholesterol, but not to LDL-cholesterol, were primarily responsible for driving the elevated risk of atherosclerosis and cardiovascular events associated with dysglycaemia within this population. Randomized intervention studies have demonstrated significant inhibition of atherosclerosis and/or improvement in cardiovascular event rates with treatments that increase HDL-cholesterol (nicotinic acid or a fibrate). Nicotinic acid is the most powerful HDL-cholesterol raising agent currently available, and a combination of this agent with a statin facilitates simultaneous control of both HDL-cholesterol and LDL-cholesterol. Indeed, the HDL Atherosclerosis Treatment Study demonstrated a reduction in major cardiovascular events of 90% vs. placebo in patients randomized to nicotinic acid + simvastatin. In addition, patients randomized to nicotinic acid in the Coronary Drug Project benefited from a significant reduction in mortality after 15 years, 9 years after the trial ended. A new prolonged-release formulation of nicotinic acid, Niaspan®, has superior tolerability compared with immediate-release nicotinic acid and facilitates the delivery of this therapy. The evidence base supporting intervention to correct low HDL-cholesterol in addition to reducing LDL-cholesterol is now sufficiently strong to support the introduction of this strategy into routine clinical practice.
Continuity of Care Document for Hospital Management Systems: an Implementation Perspective

Implementation of Electronic Health Record (EHR) has become essential towards delivery of standardized healthcare services, particularly in developing nations. Legacy hospital management systems developed earlier lack compliance to EHR guidelines and required standards. In this paper, we focus on a specific aspect of EHR, the Continuity of Care Document (CCD), which is a standard format used for ubiquitous migration of patient information and medical records across hospital management systems. We discuss the challenges involved in implementation of CCD for legacy systems and present case studies on such a system with a view to understand the gap and effort required in such an endeavour. We also introduce an SDK and web API for assisting organizations to easily extending the existing Hospital Information Systems to generate CCD. This would be useful for developers of healthcare solutions in understanding and practically implementing the same.
Radiation efficient unidirectional low-profile slot antenna elements for X-band application

Slot apertures in metallic ground planes are very attractive candidates for conformal antenna applications. However, a low-profile unidirectional antenna requires a backreflector close to the slot aperture and the resulting stripline feed causes strong excitation of parallel-plate modes. In this paper, we investigate unidirectional reflector-backed slot configurations with parallel-plate mode suppression by shorting pins. Starting from a parametric study with respect to shorting pin location and backreflector distance, we present a stripline-fed rectangular slot element with radiation efficiency of more than 80%, a bandwidth of about 5% at a center frequency of 10 GHz. For increased bandwidth applications, a bow-tie slot element with about 8% bandwidth and radiation efficiency of close to 80% is proposed.
Estratégia de Operações Internacionais: Evolução e Tendências. DOI: 10.15600/1679-5350/rau.v10n2p1-27

O presente trabalho tem por objetivo investigar como evoluiram os estudos de estrategia de operacoes internacionais e como o campo esta estruturado atualmente para atender a crescente competitividade global. O surgimento de novos atores e de novas tecnologias tem desafiado empresas a repensar sua estrategia de operacoes, levando-as a estruturar tanto a gestao de suas cadeias de fornecimento quanto as suas manufaturas em um contexto internacional. Adicionalmente, o fato de o Brasil ter tido mais recentemente um destaque internacional ao possuir tres entre as 100 maiores empresas transnacionais (UNCTAD, 2010), esta abordagem parece ser relevante e oportuna para os estudos brasileiros. Para atingir o objetivo proposto pelo presente trabalho, conduziu-se um estudo exploratorio com uma abordagem qualitativa baseado em um conjunto de artigos de gestao de operacoes internacionais. 94 artigos foram analisados, levantados a partir da revisao de literatura de 1959 a fevereiro de 2011. Com base na analise dos artigos, foi possivel estruturar uma evolucao historica dos estudos de operacoes internacionais, desde os incipientes exercicios de internacionalizacao ate os estudos contemporâneos. As principais contribuicoes do presente estudo sao: (i) oferecer uma analise evolutiva da estrategia de operacoes internacionais; (ii) apresentar um quadro referencial dos estudos integrados da internacionalizacao de operacoes a partir das areas de decisao estrategica, e; (iii) desenvolver proposicoes que poderao direcionar estudos futuros.
Gate driving of high power IGBT by wireless transmission

In high power high voltage conversion, the technology of IGBT's drivers is a very sensitive point due to the need of a high reliability and a high degree of insulation to transmit driving information and energy to the gate driver. Many techniques exist that allow an insulated transmission of the driving signal. Some, like the level-shifter or the optocoupler are commonly used in medium voltage range but are totally unsuited to high voltage. In this last case, a classical solution leads to use, for each IGBT, a DC supply with a high insulation transformer for energy transmission and an optic fiber for the transmission of information. This solution is reliable, fast, and not sensitive to disturbances. However, in the case of numerous switches to drive, this solution becomes costly and bulky. Thus, in this paper, we propose a driving system well suited to high voltage, which can be insensitive to high-level disturbances. A wireless solution coupled to an energy supply loop is proposed, in order to reduce the cost and bulkiness of high power converters. The advantage of this solution lies in a very low propagation time, a strong immunity to noise if signal coding is well studied and a simplified supply system to drivers
Characterization of a corrinoid protein involved in the C1 metabolism of strict anaerobic bacterium Moorella thermoacetica

The strict anaerobic, thermophilic bacterium Moorella thermoacetica metabolizes C1 compounds for example CO2/H2, CO, formate, and methanol into acetate via the Wood/Ljungdahl pathway. Some of the key steps in this pathway include the metabolism of the C1 compounds into the methyl group of methylenetetrahydrofolate (MTHF) and the transfer of the methyl group from MTHF to the methyl group of acetyl‐CoA catalyzed by methyltransferase, corrinoid protein and CO dehydrogenase/acetyl CoA synthase. Recently, we reported the crystallization of a 25 kDa methanol‐induced corrinoid protein from M. thermoacetica (Zhou et al., Acta Crystallogr F 2005; 61:537–540). In this study we analyzed the crystal structure of the 25 kDa protein and provide genetic and biochemical evidences supporting its role in the methanol metabolism of M. thermoacetia. The 25 kDa protein was encoded by orf1948 of contig 303 in the M. thermoacetica genome. It resembles similarity to MtaC the corrinoid protein of the methanol:CoM methyltransferase system of methane producing archaea. The latter enzyme system also contains two additional enzymes MtaA and MtaB. Homologs of MtaA and MtaB were found to be encoded by orf2632 of contig 303 and orf1949 of contig 309, respectively, in the M. thermoacetica genome. The orf1948 and orf1949 were co‐transcribed from a single polycistronic operon. Metal analysis and spectroscopic data confirmed the presence of cobalt and the corrinoid in the purified 25 kDa protein. High resolution X‐ray crystal structure of the purified 25 kDa protein revealed corrinoid as methylcobalamin with the imidazole of histidine as the α‐axial ligand replacing benziimidazole, suggesting base‐off configuration for the corrinoid. Methanol significantly activated the expression of the 25 kDa protein. Cyanide and nitrate inhibited methanol metabolism and suppressed the level of the 25 kDa protein. The results suggest a role of the 25 kDa protein in the methanol metabolism of M. thermoacetica. Proteins 2007. © 2007 Wiley‐Liss, Inc.
Immunohistochemical survey of the gut endocrine cells in the common tree shrew (Tupaia belangeri).

Regional distribution and relative frequency of endocrine cells in the gastrointestinal tract of the common tree shrew (Tupaia belangeri) were studied immunohistochemically. Ten types of immunoreactive endocrine cells were localized in the gastric mucosa, i.e., chromogranin-, serotonin-, gastrin-, somatostatin-, bovine pancreatic polypeptide (BPP)-, enteroglucagon-, pancreatic glucagon-, peptide tyrosine tyrosine (PYY)-, motilin-, and substance P (SP)-immunoreactive (IR) cells. In the intestine, 13 types of immunoreactive cells were observed, i.e., chromogranin-, serotonin-, somatostatin-, gastrin-, BPP-, enteroglucagon-, PYY-, secretin-, cholecystokinin (CCK)-, gastric inhibitory peptide (GIP)-, motilin-, neurotensin-, and SP-IR cells. The regional distribution and relative frequency of the cell types varied along the gastrointestinal tract. Basically, the types, distribution, and relative frequency of the gut endocrine cells were similar to those reported in other mammalian species. However, some characteristic findings were noted in the present study: (1) the considerably large number of gastrin-IR cells in the pyloric region; (2) numerous serotonin-IR cells in the stomach; (3) appreciable number of BPP-IR cells in the transitional region of the stomach; and (4) wide distribution of PYY- and motilin-IR cells in the gut.
Il crollo delle compensazioni IVA: efficace politica di contrasto all'evasione o effetto congiunturale?

L'obiettivo del paper e quello di fornire un contributo per la valutazione dei piu recenti interventi di contrasto all'elusione e all'evasione adottati dal Governo in materia di controllo preventivo all'utilizzo dei crediti IVA in compensazione a partire dal 1° gennaio 2010 (decreto legge 78/2009). Le compensazioni IVA avevano evidenziato un trend crescente a partire dalla loro introduzione. Nel 2010, invece, la riduzione signi cativa delle compensazioni IVA, pari a circa 5,7 miliardi di euro, ha sostenuto la dinamica del gettito IVA. Questo lavoro rappresenta una prima valutazione della tendenza in atto di riduzione delle compensazioni IVA e di aumento della tax compliance, anche alla luce della profonda contrazione dell'economia registrata nel corso del 2009. Nello speci co, si propone di valutare quanta parte della riduzione delle compensazioni IVA sia dovuta all'e etto della norma e quanta sia da attribuire alla essione del ciclo economico. Utilizzando un panel di imprese soggette agli studi di settore nel quadriennio d'imposta 2007-2010 e diverse metodologie di causal inference, si stimano gli e etti medi dell'introduzione della norma. Le imprese con ampi crediti IVA mostrano una migliore gestione del magazzino e il miglioramento del grado di compliance risulta spiegato dall'e etto dell'introduzione della norma. In particolare, la stima dell'e etto dell'introduzione della norma sulla contrazione dei crediti IVA varia dal 30% al 51,6%, a seconda degli approcci empirici utilizzati, mentre l'e etto dovuto al ciclo risulta al massimo pari all'11,4%. Tale e etto potrebbe essere ricondotto ad un meccanismo di dissuasione sul comportamento dei contribuenti, a seguito dalle modi che introdotte alla normativa nel luglio 2009.
Knowledge management for the analysis of complex experimentation

Government agencies carry out many events each year designed to determine future requirements and capabilities. These events include field experiments, surveys, interviews, simulations and workshops. Similar themes are evident across many of these events. Unfortunately, mechanisms for passing information from one event to the next, or for developing bodies of knowledge in the topical areas they address, have yet to be fully developed. The task is difficult on two fronts. In response to this need a knowledge management capability was developed to help provide structure for dynamic and static data and thereby, aid in the analysis of complex experimentation. The system warehouses qualitative and quantitative data and supports mining operations through a number of traditional and artificial intelligence‐based techniques. Described are the information architecture of the system, the knowledge processing methodologies, and the structure of the thematic data sets that form the knowledge ontologies.
BRCA 1 R 1699 Q variant displaying ambiguous functional abrogation confers intermediate breast and ovarian cancer risk

BRCA1 R1699Q variant displaying ambiguous functional abrogation confers intermediate breast and ovarian cancer risk Amanda B Spurdle, Phillip J Whiley, Bryony Thompson, Bingjian Feng, Sue Healey, Melissa A Brown, Christopher Pettigrew, kConFab, Christi J Van Asperen, Margreet G E M Ausems, Anna A Kattentidt-Mouravieva, Ans M W van den Ouweland, Dutch Belgium UV Consortium, Annika Lindblom, Maritta H Pigg, Rita K Schmutzler, Christoph Engel, Alfons Meindl, German Consortium of Hereditary Breast and Ovarian Cancer, Sandrine Caputo, Olga M Sinilnikova, Rosette Lidereau, French COVAR group collaborators, Fergus J Couch, Lucia Guidugli, Thomas van Overeem Hansen, Mads Thomassen, Diana M Eccles, Kathy Tucker, Javier Benitez, Susan M Domchek, Amanda E Toland, Elizabeth J Van Rensburg, Barbara Wappenschmidt, Åke Borg, Maaike P G Vreeswijk, David E Goldgar, on behalf of the ENIGMA Consortium
Learning brain connectivity with the false-discovery-rate-controlled PC-algorithm

Discovering the connectivity networks in the brain, i.e. the neural influence that brain regions exert over one another, has attracted increasing research attention in studies on brain functions. An important error rate criterion on the discovered network is the false discovery rate (FDR), that is the expected ratio of the falsely “discovered” connections to all those “discovered”. Very recently, we have developed an algorithm that is able to control the FDR under a given level q at the limit of large sample size, and its modification that controlled the FDR accurately in simulations with moderate sample sizes [1]. However, the algorithms do not consider prior knowledge on the network structure, and can not be applied to models such as dynamic Bayesian networks. In this paper, we extend the algorithms to incorporate prior knowledge, and demonstrate how to apply the extended algorithm to learning the structure of dynamic Bayesian networks from continuous data. Its application to a real functional-Magnetic-Resonance-Imaging (fMRI) data set revealed that Parkinson's disease patients' brain connectivities are normalized by L-dopa medication. This result is consistent with the fact that L-dopa has dramatic effects against bradykinesia and rigidity.
Non-Participative Policy Development: The Genesis of “A New Perspective on the Health of Canadians”

r D HE Green Paper, A New Perspective on the Health of , _: Canadians, was tabled in the House of Commons in g | 2 Ottawa in April, 1974. In the words of Sir George Godber, former Chief Medical Officer of Britain's Department of Health and Social Services: "The Lalonde &e ? Report from Canada (I9 74) has had a worldwide effect in making governments as well as the health professions realize that the promotion of health in future depends more on the pattern of living adopted by the individual than on technical or allied procedures. " (Milbank Memorial Fund Quarterly, Summer, 1977, p. 373). Reviews and citations in professional journals were myriad and enthusiastic, including Lancet, The New England Journal of Medicine, Preventive Medicine, The Journal of the American Hospital Association, and Health Education. Further, the Honourable Marc Lalonde (i), under whose aegis the Paper was written, received international awards for it, including the prestigious Dana Award from the American Health Foundation. What was unusual about the writing of the Paper was that it was done without the elaborate process of external and internal consultation usually followed in the production of a major government position paper. There was no departmental or interdepartmental task force, no editorial committee, no federal-provincial consultation, no discussion with outside interest groups in the field of health, and no preliminary circulation of drafts to other federal departments. Other federal departments became aware of the Paper only when it was presented to Cabinet in January, I974. Outside interest groups did not learn of the Paper until it was tabled in the House of Commons in April, I974.
irect influence of recovery behaviour on echanical properties in oxygen-free copper rocessed using different SPD techniques : PT and ECAP

Oxygen-free copper of 99.95 wt. % purity was severely deformed at room temperature by two modes of severe plastic deformation, equal-channel angular pressing (ECAP) and highpressure torsion (HPT). ECAP was performed using 4, 16 and 24 passes, and HPT was performed using 1/2, 1 and 10 turns. The results show that while recovery occurs during both ECAP and HPT processing, copper shows a faster recovery rate with HPT processing than ECAP. The occurrence of recovery was observed at an equivalent strain exceeding ∼12 that led to an enhancement in the uniform plastic deformation. The influence of recovery behaviour on the mechanical properties was investigated using X-ray diffraction, microhardness and tensile testing. ecovery train rate sensitivity ork hardening © 2017 Brazilian Metallurgical, Materials and Mining Association. Published by Elsevier Editora Ltda. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). strength in comparison to their coarse grain counterparts . Introduction igh-pressure torsion (HPT) [1–4] and equal-channel angular ressing (ECAP) [2,5–7] are the most commonly used severe lastic deformation (SPD) techniques. The HPT procedure is idely used because it has the ability to produce exceptional Please cite this article in press as: Alawadhi MY, et al. Direct influence of processed using different SPD techniques: HPT and ECAP. J Mater Res Tech rain refinement [4,8] and a large fraction of high-angle grain oundaries [9], while ECAP is popular because it is a simle process that has the ability to deform larger samples Paper was a contribution part of the 3rd Pan American Materials Con ∗ Corresponding author. E-mails: mya1c12@soton.ac. uk (M.Y. Alawadhi), y.huang@soton.ac. u ttp://dx.doi. org/10.1016/j.jmrt. 2017.05. 005 238-7854/© 2017 Brazilian Metallurgical, Materials and Mining Assoc rticle under the CC BY-NC-ND license (http://creativecommons.org/lic which makes it a better candidate for structural applications [10–12]. It is well established that bulk ultrafine-grained (UFG) materials are successfully produced by SPD with very small grain sizes in the range between 1 m and 100 nm [2,13–16]. UFG materials normally exhibit an extraordinary increase in recovery behaviour on mechanical properties in oxygen-free copper nol. 2017. http://dx.doi. org/10.1016/j.jmrt. 2017.05. 005 gress, February 26th to March 2nd, 2017. k (Y. Huang). [17,18]. The inverse relationship between the yield stress ( y) and the square root of the grain size (d) is described by the Hall–Petch relationship [19,20]: iation. Published by Elsevier Editora Ltda. This is an open access enses/by-nc-nd/4.0/). ARTICLE IN PRESS JMRTEC-256; No. of Pages 9 o l . 2 2 j m a t e r r e s t e c h n
Periodontitis and Rheumatoid arthritis - A Review

The periodontal disease is an inflammatory condition of the supporting structres of the teeth. The presence of rheumatoid arthritis or other systemic inflammatory disease may increase the severity of the periodontal disease. The studies published in the past reveals that the oral bacterial infections and inflammation seemed to be linked directly to the etiopathogenesis of rheumatoid arthritis. There are findings support the impact of periodontal pathogens, such as Porpyromonas gingivalis on citrullination, and the association of periodontitis in rheumatoid arthritis patients with serospecificity toward rheumatoid factor and the anti-cyclic citrullinated peptide antibody 1 . In this review the common etiology, pathogenesis and immunogenetics of two