Miracle-dz/UniFAR-FTUs huggingface dataset:
Flickr: a case study of Web2.0

Purpose – The “photosharing” site Flickr is one of the most commonly cited examples used to define Web2.0. This paper aims to explore where Flickr's real novelty lies, examining its functionality and its place in the world of amateur photography. Several optimistic views of the impact of Flickr such as its facilitation of citizen journalism, “vernacular creativity” and in learning as an “affinity space” are evaluated.Design/methodology/approach – The paper draws on a wide range of sources including published interviews with its developers, user opinions expressed in forums, telephone interviews and content analysis of user profiles and activity.Findings – Flickr's development path passes from an innovative social game to a relatively familiar model of a web site, itself developed through intense user participation but later stabilising with the reassertion of a commercial relationship to the membership. The broader context of the impact of Flickr is examined by looking at the institutions of amateur photo.
Les fondements neurophysiologiques de la latéralisation motrice : le paradigme des mouvements en miroir

Le syndrome des mouvements en miroir congenitaux (MMC) est une maladie genetique caracterisee par l’existence de mouvements involontaires symetriques d’une main qui reproduisent a l’identique les mouvements volontaires de l’autre main. Deux structures sont impliquees dans la physiopathologie de cette maladie : le corps calleux (CC) et le faisceau corticospinal (FCS). Deux genes ont ete lies aux MMC a ce jour : DCC et RAD51. Tandis que DCC joue un role crucial dans le guidage des axones commissuraux, RAD51 intervient dans la reparation de l’ADN, et son role dans le developpement du systeme moteur etait inattendu.Chez la souris, nous avons etudie le role de RAD51 et DCC dans le developpement du FCS et du CC, ainsi que l’implication de ces deux structures dans la lateralisation du controle moteur. Nous avons prouve que DCC controle le guidage du FCS a la ligne mediane de facon indirecte. RAD51 intervient dans le developpement du neocortex, mais son role precis dans le developpement du systeme moteur demeure inconnu. Nous avons par ailleurs compare un groupe de patients MMC a des volontaires sains afin d’etudier la lateralisation de l’activite corticale lors de la preparation motrice. L’activation et les interactions inter-hemispheriques des aires motrices sont anormales des la preparation du mouvement chez les patients MMC. L’inhibition de l’aire motrice supplementaire (AMS) chez les volontaires sains reproduit les defauts d’interactions inter-hemispheriques observes chez les patients. Ces resultats suggerent que l’AMS est impliquee dans la preparation des mouvements lateralises, potentiellement en modulant les interactions entre les deux hemispheres via le CC.
Novel murine B‐cell lymphoma/leukemia model to study BCL2‐driven oncogenesis

The BCL‐2 family has been implicated in the pathogenesis of various hematopoietic malignancies, including follicular non‐Hodgkin lymphoma and B‐cell chronic lymphocytic leukemia. To identify genes that act synergistically in BCL2‐enforced leukemogenesis, we developed a murine B‐cell lymphoma/leukemia model based on the IL‐3‐dependent Balb/C pro‐B line (FL5.12). FL5.12 cells were stably transfected with antiapoptotic BCL‐2 alone or in combination with proapoptotic BAX or nonfunctional mutant BAX, thereby creating various levels of imbalance within the BCL‐2 family. Transfectants were intravenously injected into normal Balb/C mice. Whereas FL5.12 cells did not provoke leukemia, mice injected with stable transfectants died of leukemia over time. Disease incidence and latency time depended on the degree of imbalance in the BCL‐2 family, supporting a model whereby BCL2 drives tumorigenesis. All mice presented with hepatosplenomegaly and leukemic FL5.12 cells in peripheral blood and bone marrow compartments. Leukemic conversion was accompanied by secondary genetic aberrations leading to clonal IL‐3‐responsive leukemia. Cellular transformation was independent of alterations in c‐Myc or downstream apoptotic pathway. Leukemic clones retained a normal DNA damage response leading to elevated P53 and P21 levels and cell cycle arrest upon irradiation. In conclusion, our mouse model may prove a valuable tool to identify genes that cooperate in BCL2‐enforced lymphoma/leukemogenesis. © 2004 Wiley‐Liss, Inc.
Adaptive training instance selection for cross-domain emotion identification

This paper exploits a large number of self-labeled emotion tweets as the training data from the source domain to improve emotion identification in target domains (i.e., blogs and fairy tales), where there is a short supply of labeled data. Due to the noisy and ambiguous nature of self-labeled emotion training data, the existing domain adaptation methods that typically depend on high-quality labeled source-domain data do not work satisfactorily. This paper describes an adaptive source-domain training instance selection method to address the problem of noisy source-domain training data. The proposed approach can effectively identify the most informative training examples based on three carefully designed measures: consistency, diversity, and similarity. It uses an iterative method that consists of the following steps in each iteration: selecting informative samples from the source domain with the informativeness measures, merging with the target-domain training data, evaluating the performance of learned classifier for the target domain, and updating the informativeness measures for the next iteration. It stops until no new training instance is selected or in a designated number of iterations. Experiments show that our approach performs effectively for cross-domain emotion identification and consistently outperforms baseline approaches across four domains.
Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi

Epsin is a ubiquitin-binding endocytic adaptor, which is highly concentrated at clathrin-coated pits and coordinates acquisition of bilayer curvature with coat recruitment and cargo selection. Epsin is encoded by three distinct genes in mammals. Epsin 1 and 2 have broad tissue distribution with high-level expression in the brain. In contrast, epsin 3 was reported to be expressed primarily in immature keratinocytes. Here, we show that epsin 3 is selectively expressed at high levels in the stomach (including the majority of gastric cancers), where it is concentrated in parietal cells. In these cells, epsin 3 is enriched and colocalized with clathrin around apical canaliculi, the sites that control acidification of the stomach lumen via the exo-endocytosis of vesicles containing the H/K ATPase. Deletion of the epsin 3 gene in mice did not result in obvious pathological phenotypes in either the stomach or other organs, possibly because of overlapping functions of the other two epsins. However, levels of EHD1 and EHD2, two membrane tubulating proteins with a role in endocytic recycling, were elevated in epsin 3 knock-out stomachs, pointing to a functional interplay of epsin 3 with EHD proteins in the endocytic pathway of parietal cells. We suggest that epsin 3 cooperates with other bilayer binding proteins with curvature sensing/generating properties in the specialized traffic and membrane remodeling processes typical of gastric parietal cells.
Using SOAP to clean up configuration management

Software products have become increasingly complicated over the past decade. For example, software is no longer restricted to a single binary file constructed from a small number of source files residing at a single location. Products today are frequently split across client and server architectures with further complications arising through the need for the client and the server to be built and run on different platforms, developed and deployed in multiple physical locations and by workers spanning several different time zones. These factors contribute to making modern software configuration management (CM) a vital but extremely complex process. In this paper we describe a new method for managing the configuration management of evolving modern day distributed systems based on the use of emerging web technologies, specifically XML (Extended Markup Language) XML-RPC (XML-Remote Procedure Call) and SOAP (Simple Object Access Protocol).
Regeneration and resurrection in Matthew - Peasants in campo hearing time signals from scribes

The article aimed to describe the distinctive element in the use of the motif of the resurrection in the Gospel of Matthew in comparison with Mark, Luke and the Sayings Gospel Q. It argued that the distinctive element occurs where parallel texts in Luke 22:24–30, Matthew 19:27–29 and Mark 10:28–31 converge. The distinctive element pertains particularly to the meaning of the Greek expression ‘en tē palingenesia’ in Matthew 19:28. By elaborating on time as a social construct, the article showed how Matthew deals with the conception of time differently than both Mark and Luke. It illustrated that the Gospel of Matthew represents a storyline consisting of a circular movement between ‘genesis’ (Mt 1:1) and ‘palingenesia’ (Mt 19:28), where the word ‘palingenesia’ denotes the meaning ‘regeneration’ rather than ‘resurrection’. Matthew does not narrate an abrupt transition from linear time to clock time. Both co-existed in a world where illiterate peasants and literate scribes scheduled their lives in terms of motifs pertaining to a linear and a punctual conception of time.
Preparation and properties of poly (lactic acid) (PLA) suture loaded with PLA microspheres enclosed drugs (PM-Ds)

Abstract Drug loaded PLA suture has been one most potential surgery material to help wounds healing. The loaded drug amounts and sustained drug release effect were a vital part for PLA suture. In this research drug-loaded microspheres and finishing bath were prepared to ensure more drug particles loaded on PLA suture. Moreover, sustained drug release effect and mechanical properties of PLA suture were also observed. The results suggested that PLA concentration and emulsifier amounts had more effect on the size of PLA drug-loaded microspheres and the optimal technology was: 0.03 g/mL of PLA concentration, 0.3 g of amount of emulsifier and the total amount of drug and emulsifier was 3 g. Moreover, drug release test showed a significant sustained release effect of the drug-loaded PLA suture. Mechanical measurements indicated the flexibility and strength were not impaired by such drug-loaded method. This research is expected to benefit the surgery fields further. Graphical Abstract
Zirconia versus metal: a preliminary comparative analysis of ceramic veneer behavior.

PURPOSE Clinical studies have revealed a high rate of fracture for porcelain-veneered zirconia-based restorations that varies between 6% and 15% over a 3- to 5-year period. These are high values compared to the 4% fracture rate shown by conventional metal-ceramic restorations over 10 years. To date, little in vitro research has been carried out on the fracture resistance of the new generation of ceramic crowns. The aims of this study were to develop preliminary research on the mechanical failure behavior of three types of porcelain-veneered crowns with zirconia cores when subjected to static compressive loading and to analyze fracture characteristics using scanning electron microscopy (SEM). MATERIALS AND METHODS Eighty individual full-coverage crowns were studied: 60 crowns with a zirconia core and 20 with a metal core (control). RESULTS Values obtained in compressive testing were as follows: ZirPress: 1,818.01 N, ZirCAD: 1,773.92 N, Lava: 2,210.95 N, and metal-ceramic (control): 2,310.49 N. SEM analysis revealed that 71.66% of zirconia-based restoration mechanical failures were cohesive, while 100% of mechanical failures for metal-ceramic restorations were adhesive. CONCLUSIONS The mechanical behavior of the porcelain veneering on a zirconia core is more fragile than that on metal-ceramic crowns, and when load forces exerted on these restorations lead to mechanical failure, this will occur in the interior of the porcelain veneering.
Deletion of PDE2, the gene encoding the high‐affinity cAMP phosphodiesterase, results in changes of the cell wall and membrane in Candida albicans

A role for the cAMP‐dependent pathway in regulation of the cell wall in the model yeast Saccharomyces cerevisiae has recently been demonstrated. In this study we report the results of a phenotypic analysis of a Candida albicans mutant, characterized by a constitutive activation of the cAMP pathway due to deletion of PDE2, the gene encoding the high cAMP‐affinity phosphodiesterase. Unlike wild‐type strains, this mutant has an increased sensitivity to cell wall and membrane perturbing agents such as SDS and CFW, and antifungals such as amphotericin B and flucytosine. Moreover, the mutant is characterized by an altered sensitivity and a significantly reduced tolerance to fluconazole. The mutant's membrane has around 30% higher ergosterol content and the cell wall glucan was 22% lower than in the wild‐type. These cell wall and membrane changes are manifested by a considerable reduction in the thickness of the cell wall, which in the mutant is on average 60–65 nm, compared to 80–85 nm in the wild‐type strains as revealed by electron microscopy. These results suggest that constitutive activation of the cAMP pathway affects cell wall and membrane structure, and biosynthesis, not only in the model yeast S. cerevisiae but also in the human fungal pathogen C. albicans. Copyright © 2005 John Wiley & Sons, Ltd.
A novel hyperspectral image clustering method based on spectral unmixing

In this paper, a novel hyperspectral image clustering procedure, which is based upon the Fully Constrained Least Squares (FCLS) spectral unmixing method, is proposed. The proposed clustering method consists of three major steps: endmember extraction, unmixing procedure and hardening process via the winner-takes-all approach. To estimate the optimal number of endmembers, instead of using the background signal subspace identification methods, the number of endmembers is varied in a predefined interval and the commonly accepted VCA (Vertex Component Analysis) algorithm is employed to extract the endmembers' spectra. At each iteration, the bandwise Root Mean Square Error (RMSE) between the reconstructed image, obtained from estimated fractions. and the original image is computed and the mean of all bandwise RMSEs is regarded as a measure to choose the optimum number of endmembers. Experiments conducted on the Indian Pines challenging dataset proved the superiority of proposed method over the K-Means and Fuzzy c-Means methods in terms of the widely used Adjusted Rand Index measure.
Evaluation of the adverse effect of premature discontinuation of pegylated interferon α‐2b and ribavirin treatment for chronic hepatitis C virus infection: Results from Kyushu University Liver Disease Study

Background and Aims: Pegylated interferon (PEG‐IFN) α‐2b and ribavirin (RBV) treatment of chronic hepatitis C virus (HCV) infection is associated with a substantially elevated risk of discontinuation. The aim of this study is to evaluate the reason for premature discontinuation during PEG‐IFN α‐2b and RBV treatment due to adverse effects in patients with chronic HCV infection.
Effects of Diluents , Cryoprotectants , Equilibration Time and Thawing Temperature on Cryopreservation of Duck Semen

A series of sequential experiments were carried out to determine optimum diluents, cryoprotectants, equilibration time, and thawing temperature for frozen duck semen in order to set up the commercial semen cryopreservating techniques which could be applied to the conservation of genetic resources, breeding, and commercial production in domestic ducks. In experiment 1, the seven semen extenders were studied to determine efficacy of the diluent on cryopreservation of duck Semen. The result showed that the diluent which contains 0.14% potassium citrate, 1.40% sodium glutamate, 0.98% disodium hydrogen phosphate, 0.21% sodium dihydrogen phosphate, 0.7% glucose, and 0.7% inositol was better than other six semen diluents. In experiment 2, the effects of various concentrations of cryoprotectants including glycerol, dimethyl sulphoxide (DMSO), dimethyl acetamide (DMA), and dimethyl formamide (DMF) on cryopreservation of bird semen were evaluated. The results showed that the cryoprotectant containing 10% DMSO was better than others. The experiment 3 was conducted to determine the effect of equilibration time and thawing temperature on cryopreservation of bird semen. The optimum equilibration time was 15 min and the optimum thawing temperature was 40 C o
ReClaim: a Privacy-Preserving Decentralized Social Network

The privacy concerns associated with the popularity of online social networks have given rise to numerous research papers which focus on either storing the data in encrypted form, or decentralizing the network. However, without the incentive of being able to read private data, a centralized system cannot be sustained. A decentralized network does not rely on such incentives and can continue to operate based solely on user contributed resources. Unfortunately, current proposals either still rely on centralized components, a pre-existing friend-tofriend network, or incur substantial bandwidth overhead. This renders them useless for actual deployment. ReClaim employs an existing technique to the PSI problem to build a semantic network wherein peers have connections to friends and friends-of-friends. This is achieved by a handshake which uses homomorphic encryption to privately determine which friends are shared amongst two peers. Afterwards, peers synchronize messages destined for friends, providing them with easy access to replicas. Moreover, storing those messages allows ReClaim to handle excessive churn (peers joining and leaving the network at a high rate), overcome NATfirewalls (by allowing for indirect communication), and allow friends to communicate without being online at the same time. After describing the design of ReClaim, we implement a proof-of-concept application and show during extensive emulation that peers can connect to more than 60% of their friends within 10 minutes in a network consisting of 4000 peers. Moreover, within 10 minutes, peers using ReClaim can establish an indirect connection to 95% of their friends.
Proyecciones financieras y de bienestar del sistema español de pensiones: modelización en equilibrio general

Este documento presenta los detalles de formulacion y calibracion de un modelo de equilibrio general dinamico de generaciones solapadas de gran escala de la economia espanola. El modelo esta disenado para generar proyecciones coherentes del comportamiento de los agregados macroeconomicos y de pensiones, asi como del bienestar de las distintas generaciones, sobre un horizonte temporal muy dilatado (hasta 2070). Se revisan los cambios introducidos respecto de la ultima version existente del modelo (Sanchez-Martin (2014)) y se discuten posibles mejoras futuras.
Lane Surface Identification Based on Reflectance using Laser Range Finder

In striving to achieve autonomous navigation the problem of guidance is a major difficulty faced by fully autonomous vehicle. In this paper, the authors focus on unconventional methods of identifying lane markings on a road surface through Laser Measurement System (LMS). This was achieved by taking advantage of the reflection of the laser beam. This method was executed in three steps, firstly to detect lane markings we employed the spatial clustering of applications with noise (DBSCAN) method. Secondly, in order to determine the surface course a distance clustering analysis was implemented and lastly, the road geometry design was estimated with preliminary results being gathered and tested on a group of consecutive frames to prove its effectiveness.
Serotonin‐ and substance P‐containing projections to the nucleus tractus solitarii of the rat

The objective of the present study was to determine the location of the neurons that give rise to serotonin‐ and substance P‐containing terminals in the nucleus tractus solitarii. This was done by injecting rhodamine‐filled latex microspheres into the nucleus tractus solitarii of rats to retrogradely label neuronal cell bodies and by processing sections from the brains of these animals to determine whether the labelled neurons contained serotonin or substance P immunoreactivity. Serotonin‐immunoreactive neurons that projected to the nucleus tractus solitarii were found in the nucleus raphe magnus, nucleus raphe obscurus, nucleus raphe pallidus, and in the ventral medulla, lateral to the pyramidal tract. Substance P‐immunoreactive neurons that projected to the nucleus tractus solitarii were found in similar areas but were proportionately less numerous in the nucleus raphe magnus and proportionately more numerous in the nucleus raphe pallidus. It is concluded that neurons in the medullary raphe nuclei, some of which presumably utilize serotonin or substance P as a neurotransmitter, could regulate autonomic function via direct projections to the nucleus tractus solitarii.
Yerli ve Yabancı Yatırımcılara Ait Risk İştahlarının İncelenmesi: Türkiye Örneği

Bu calismada Turkiye’de Merkezi Kayit Kurulusu (MKK) tarafindan haftalik bazda yayinlanan ve finansal istikrar olcusu olarak kabul edilen, yerli ve yabanci yatirimcilara ait risk istahi verilerinin tahmin edilebilirligi incelenmistir. 2008 - 2013 donemlerindeki verilerin incelendigi calismada ADF, KPSS gibi birinci nesil birim kok testlerinin yaninda yapisal kirilmayi dikkate alan Lee ve Strazicich (2003) testi ile Caner ve Hansen (2001) esikli birim kok testi gerceklestirilmistir. Calismadan elde edilen sonuclar yerli yatirimcilara ait risk istahi verilerinin dogrusal oldugunu ve esik etkisinin olmadigini ortaya koymaktadir. Yabanci yatirimcilara ait risk istahi serisinin ise dogrusal olmadigini ve esik etkisinin var oldugu tespit edilmistir. Ayrica yabanci yatirimcilara ait risk istahinin dusme egiliminde oldugu donemlerde tahmin edilebildigi, artma donemlerinde ise tahmin edilemedigi ortaya konulmaktadir.
Proteins recognize a histone code at histone H 3 and are required for transcriptional activation

Stefan Winter, Elisabeth Simboeck, Wolfgang Fischle, Gordin Zupkovitz, Ilse Dohnal, Karl Mechtler, Gustav Ammerer and Christian Seiser* Max F Perutz Laboratories, Vienna Biocenter, Medical University of Vienna, Vienna, Austria, Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany, Christian Doppler Laboratory for Proteome Analysis, Vienna, Austria and Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria