Miracle-dz/UniFAR-FTUs huggingface dataset:
The Physiopathological Crossroads of Aging

Stress, inflammation and Plasminogen activator inhibitor 1 (PAI-1) are key mechanisms throughout the development of aging, constituting a crossroad in the most frequent pathologies that accompany it. Among metabolic processes, obesity, metabolic syndrome and type 2 diabetes mellitus are included and Alzheimer’s disease among the neurodegenerative processes. Stress is a mechanism of defense of the organism against exogenous and endogenous actions called stressors. In the case of low intensity stimuli, the organism responds with actions aimed at a physiological adaptation (Homeostasis). On the other hand, when a high intensity (experimental level) or chronic stimulus (oxidative stress) is repeated, structural and functional changes are observed in different organs with activation of the hypothalamus-pituitary-adrenal axis, the renin angiotensin system and the sympathetic nervous system, stimulating the production of hormones that release cytokines with proin-flammatory/antiinflammatory properties that play an important role in the previously mentioned pathologies, as well as a marked increase in PAI-1, a gene regulated by stress and by cytokines, with manifest action at the origin of thromboembolic disease, so frequent in aging. The objective of this review is to highlight the importance of the binomial stress and PAI-1 in aging and in the pathologies that accompany it. Because PAI-1 is part of the pathology and complications in aging, some authors suggest the study of PAI-1 inhibitors to achieve its physiological levels, as part of the treatment of these diseases.
Epidemiology of micronutrient deficiencies in agricultural reproductive-aged female workers in Southeastern Anatolia, Turkey

Abstract Deficiencies of micronutrients, especially iron, folate, and vitamin B 12 , among women of reproductive age are known causes of serious maternal and child health problems. The purpose of this study was to find out the prevalence of anemia, and vitamin B 12 and folate deficiencies and risk factors among reproductive-aged married women in an agricultural population . A cross-sectional study was conducted on the random sample of 749 reproductive age women in nine provinces of the southeastern Anatolia region of Turkey in 2013. Chi-square test and logistic regression were applied for the data analysis. The results indicated that 36%, 24.3%, and 1.6% of the women had anemia, vitamin B 12 and folate deficiencies, respectively. Seasonal agricultural workers, illiterate women, and those living in rural areas had a higher prevalence of anemia, and micronutrient deficiencies after analysis of the confounders. These data indicated the necessity of a public health program for the prevention and early diagnosis of micronutrients including enhanced biological surveillance systems, developed B 12 monitoring program, and community empowerment programs to decrease micronutrients deficiencies in agricultural reproductive age women. Keywords: Anemia, B12 and folate deficiencies, Agricultural reproductive aged women
Assessing Limb Symmetry using the Clinically Accessible loadsol

Background: The assessment of loading during walking and running has historically been limited to data collection in laboratory settings or with devices that require a computer connection. This study aims to determine if the loadsol®, a single sensor wireless insole, is a valid and reliable method of assessing force. Methods: Thirty (17 male, 13 female) recreationally active individuals were recruited for a two visit study where they walked (1.3 m/s) and ran (3.0 and 3.5 m/s) at a 0%, 10% incline and 10% decline, with the visits about 1 week apart. Ground reaction force data was collected on an instrumented treadmill (1440 Hz) and with the loadsol® (100 Hz). Ten individuals completed the day 1 protocol with a newer 200 Hz loadsol®. Intraclass correlation coefficients (ICC3,k) were used to assess validity and reliability, and Bland-Altman plots were generated to better understand loadsol® validity. Results: Across conditions, the peak force ICCs ranged from 0.78-0.97, which increased to 0.840. 99 with the 200 Hz insoles. Similarly, the loading rate ICCs improved from 0.61-0.97 to 0.800. 96 and impulse improved from 0.61-0.97 to 0.90-0.97. Discussion: The 200 Hz insoles may be needed for loading rate and impulse in running. For both walking and running, the loadsol® has excellent between day reliability (>0.76).
Comparison of ad hoc and centralized multihop routing

In order to improve coverage and alleviate traffic congestion in single-hop cellular networks (SCN), such as GSM, a new radio network architecture, multihop cellular networks (MCN), was proposed and analyzed (see Lin, Y.D. et al., IEEE INFOCOM, 2000). MCN architecture can improve the coverage and system capacity of SCNs by up to 40%. A detailed concept for realizing the MCN architecture was suggested by R. Ananthapadmanabha, et al. (see Proc. PIMRC, 2001), where a cellular based multihop routing protocol was developed and investigated. Their results indicate that MCN with the cellular based routing protocol provides much higher system throughput than SCN. However the paper gave no reasons for using cellular based routing instead of the ad hoc multihop routing protocols specified by IETF (see www.ietf.org). This paper is intended to fill that gap with the help of an analysis of routing protocol efficiency. We compare a cellular based routing protocol with three ad hoc routing protocols, DSR, AODV and DSDV. Based on analytical results, it can be concluded that the overhead of the cellular based routing protocol is not heavily influenced by network size and mobility. This translates to excellent scalability for large and dynamic MCNs, while AODV, DSR and DSDV are suitable for MCNs with a small number of hops and low mobility.
INSTRUCTION SET ARCHITECTURE OF MAMBA, A NEW VIRTUAL MACHINE FORPYTHON

Python programs are implemented by compiling them into code for a virtual machine. Mamba is a new virtual machine for Python whose design is minimalist and register−based. In contrast, the current Python virtual machine is stack−based and contains almost six times as many instructions as Mamba. We anticipate that our smaller instruction set will greatly simplify optimization implementation. In this paper we detail Mamba’s instruction set and execution model.
A Novel Self-healing Control Method for Distributed Generating System

In order to fully utilize DG and improve system reliability, the author puts forward the rash recovery strategy for distribution network with DG. It adopts the heuristic method by taking DG as the source point of research for distribution network power recovery. Based on simplifying the network through improving branch method with the consideration of purposes of network damage to minimum extent and switch action time, it conducts reconstruction after the crash. It optimizes the power supply recovery strategy according to the load transfer condition after the crash in order to minimize the damage to distribution network caused by blackout. It conducts example test at IEEE33 node and IEEE69 node to verify the validity of this scheme.
System competence – Are elementary students able to deal with a biological system?

The objective of this study was to elucidate elementary school students’ (9-11 years of age) system competence. Starting from systems theory, a framework for system competence assessment was developed to analyse the relevant abilities. This framework describes the skills for system modelling and the ability to deal with system properties. In a pre/post-test-design 363 elementary school students were tested. Questionnaires and concept maps were applied to answer the research questions whether they are capable of creating a model of a given biological system and of recognizing specific system properties. The results indicate that elementary school students already show system competence in the tested domain “system stork”. Their system organisation abilities were higher than their abilities to deal with system properties, such as predicting the consequences of changes or assessing complex effects in a system.
An improved frequency offset estimator for OFDM applications

An efficient algorithm has been proposed by Schmidl and Cox (see IEEE Trans. Commun., p.1613-21, 1997) for carrier frequency estimation in orthogonal frequency division multiplexing systems. The scheme is based on the transmission of a training symbol composed of two identical halves in the time domain. Its accuracy is close to the Cramer-Rao bound and its estimation range, which is originally limited to the distance between two adjacent subcarriers, can be widened by exploiting a second training symbol containing some suitable pseudonoise sequence. In this paper we extend this algorithm by considering a training symbol composed of L>2 identical parts. This makes it possible to achieve a better accuracy at the cost of some increase in computational load. Furthermore, the estimation range can be widened in proportion to L without the need of a second training symbol.
Application of OLGA (Operative link on gastritis assessment) staging system for gastritis in alcoholics- a cross sectional study

Introduction: Gastritis is an inflammatory condition of the gastric mucosa. Atrophy of the gastric mucosa is the endpoint of chronic processes, such as chronic gastritis associated with H. pylori infection. Currently, no reporting scheme/terminology for chronic gastritis is available that is both easily understood by clinicians and patients and also provides prognostic and therapeutic information in unequivocal terms. An international group Operative Link on Gastritis Assessment (OLGA) proposed a staging system for reporting gastric histology. This gastritis staging integrates the atrophy score (obtained by biopsy) and the atrophy topography (achieved through directed biopsy mapping). This prospective cross‐sectional study aimed to apply the OLGA staging system for reporting gastric histology in alcoholic patients with gastritis, thus validate the OLGA gastritis staging system as a routine histology reporting system. Materials and Methods: A prospective study was conducted from October 2013 to June 2015 in the Department of Gastroenterology, M.S. Ramaiah Hospitals (M.S. Ramaiah Teaching Hospital and M.S. Ramaiah Memorial Hospital), Bangalore. 150 alcoholic patients were involved in the study. Age, sex, presenting complaints and detailed history regarding alcohol intake was taken followed by investigations like Complete Blood Count, Liver Function Tests, Renal Function Tests and ultrasound abdomen. Patients were categorised clinically into 4 groups as Alcohol Dependence Syndrome (ADS), fatty liver, Compensated Liver Disease (CLD) and Decompensated Liver Disease (DCLD). Rapid urease test was done for all the patients and 5 biopsy samples (2 from antral mucosa, 2 from oxyntic area and one from the mucosa of the incisura angularis.) were obtained and sent to the pathology department. Sections made from these gastric biopsies were stained with H and E and Giemsa stain. Sections were then evaluated for the presence of H. pylori. Severity of atrophic gastritis was noted and finally OLGA scoring was given for each patient. Results: In the 150 alcoholic patients included in the study, prevalence of H. pylori was 76%. The age and the gender did not play a role in the H. pylori infection. ADS constituted 53 patients (35.3%), Fatty liver 21 (14%), CLD 39 (26%), DCLD 37 (24.7%). H. pylori prevalence was 60.4%, 71.4%, 82.1% and 94.6% respectively. With the increase in OLGA staging, number of H. pylori positive patients increased, which is statistically significant (p value is <0.001). Majority of the patients with ADS belonged to OLGA stage 0 (37 cases, 69.8%) and majority of the patients with DCLD belonged to OLGA stage II (26 cases, 70.3%). The current study revealed that the OLGA staging increased with worsening of the ALD. Conclusion: The OLGA staging increases as the clinical presentation of ALD worsens. With the increase in OLGA staging, number of H. pylori positive patients increased. The new OLGA staging system proved easy to use and provides clear prognostic information.
The features of insulin pump therapy for treatment of diabetes mellitus

Diabetes mellitus is a world-wide problem that causes incessant search for new areas of treatment of this disease. The incidence of diabetes mellitus is rising and expected to rise further, because of an ageing population and an increasing prevalence of obesity. Continuous subcutaneous insulin infusion or insulin pump therapy is recommended as a possible treatment of type 1 diabetes mellitus in children and adults, as well as type 2 diabetes mellitus if the multiple daily injections of insulin or its analogs are not effective, and also in patients with frequent hypoglycemic states. For continuous subcutaneous insulin used external pump that provides a continuous supply of insulin from the reservoir via subcutaneously administered cannula. There are an insulin dose calculator, programmable basal and bolus insulin infusion, different types of infusion sets among options of most insulin pumps. Insulin pump operates using insulin analogues ultrashort action. Insulin pump therapy should only be started by a qualified specialist team, which should provide patient education on the use of insulin pumps, provide advice on lifestyle and physical activities that are appropriate for these patients. Amid continuous subcutaneous insulin infusion the variability of blood glucose significantly was reduced, the glycosylated hemoglobin rate was decreased, the control of the «dawn phenomenon» improved. Insulin pump therapy in patients with the both type of diabetes mellitus improves quality of life.
A Lifelong Learning Approach for Improving Accurate Face Recognition

With the popularity of artificial intelligence and computer vision, an increasing number of software engineers attempt to make their systems be able to recognize the user, through the way of face recognition, e.g., Characteristic Points (i.e., CP)-based face recognition. Generally, the traditional CP- based face recognition only work when the user's face is not much different from the one that stores in the system. However, users' faces can change a lot intentionally or unintentionally, which brings a great challenge for correct face recognition. In view of this challenge, a novel face recognition approach LL-FR (Lifelong Learning-based Face Recognition) is put forward in this paper. Concretely, the system stores not only the face image that the user registered, but also the images every time when it recognizes the user's face. Afterwards, the system makes the future recognition of the user based on all the previous faces of him/her. Finally, through a set of experiments, we demonstrate the feasibility of our approach.
Analysis of Twitter Lists as a Potential Source for Discovering Latent Characteristics of Users

We discuss our findings from a study using Twitter lists to infer the characteristics and interests of users. Gathering and structuring user interest has been challenging because it often requires expensive and/or proprietary data such as users' clickthrough logs or desktop histories. We show that by using the tweets of all the users in a Twitter list, we can discover characteristics and interests of the users in that list, even if the users as individuals do not tweet about those interests. We conducted an experiment in which we compared the user interests as found by our system using Twitter lists with those that are perceived by the human subjects in the user survey. The survey confirmed that Twitter lists reflect well the perceived characteristics and interests of the users in those lists. The user survey also confirmed that the words extracted from each set of lists are representative of all the members in the list even if the words are not used by those members.
City Metaphor based Visualisation of Collaborative Work Spaces in Tower

This paper describes the application of space syntax techniques (Hillier & Hanson, 1984; Hillier, 1996) for the development of virtual environments presenting TOWER, the The-atre of Work, which allows project members to be aware of project relevant activities as well as to establish social relationships to intensify team coherence (Prinz, et al. 2003). Diﬀerent prototypes illustrate the evolution of the use of various rules for the creation of the Theatre of Work “stage”. Although the city metaphor has previously been applied in some approaches for data visualisation (Flavia, 1997), very little attention has so far of awareness and co-presence of users associated with thematically related groups of objects. Here we report on the implementation of space syntax derived conceptual models and illustrate associated implementation issues of dynamic information mapping in Theatre of Work stage visualisations. We further review user experiences of the system and discuss some of the limits in applying urban metaphors and space syntax techniques to data visualisation. We then point at issues raised by this approach that need to be resolved in future.
Communication evaluation in international organisations: methodology, influence and use

International organisations (IOs) wield considerable influence in today’s world. Distinguishing them from other actors are the new ideas they produce and communicate that can reframe global debates. However, there is little research about how these organisations evaluate their communication activities. This thesis sets out to fill this gap by providing the first in-depth study of communication evaluation within IOs. The central question of this thesis is to assess the extent to which communication evaluation is possible within IOs with three specific questions: 1) the appropriateness and feasibility of communication evaluation methodology for IOs; 2) the influence of internal and external factors; and 3) the use of communication evaluation findings in IOs. These questions are addressed in three distinct but interlinked empirical studies framed by a conceptual framework. Article 1 provides a 15 year review of communication evaluation within IOs through analysing systematically evaluation reports. Article 2 provides an analysis and reflection on the evaluation by this author of two communication campaigns of IOs. Article 3 provides a comprehensive study on the use of evaluation findings of these two communication campaigns. This thesis found that a process of conceptualisation is needed to match the given communication activities to an appropriate evaluation methodology, implemented with a pragmatic, adaptive and participatory approach rather than imposing a standard set of methods. Evaluation was found only in a minority of IOs and there are challenges in matching evaluation methods to the range and complexity of their communication activities. Internal factors of organisational context and communication goals were found to be important and to equally impede and enable the evaluation process. Improving the efficiency of communication activities was the main use seen of evaluation findings, occurring in unexpected and often opportunistic ways, but nevertheless an indication of a specific contribution of evaluation for communication professionals.
Evaluation of the effect of combined traditional Chinese and western medicine on cervical erosion

Purposeevaluate the effect of integrated Chinese and Western medicine on cervical erosion.methodSelect cervical erosion patient197Example, divided byrandomly selectedasResearch Group$Example vs control groupexample.All patients are given ice boron scatter,ornidazoletablets for conventional Western medicine treatment;Research group adds a customHeat-and-dampness Herbal decoction treatment.Comparison observation two methods of treatmentIdegree,IIdegree,IIIdegree of cure for cervical erosion,Two groups of related symptoms after medicationvanishing rate.resultself-clearing herbs decoction combined with conventional WesternmedicineIdegree,IIdegree,IIIThe recovery rate of the degree of cervical erosion is higher than that of the pureWestern medicine,and the difference is statistically significantCP<0.05;self-clearing and moistening herbs decoction combined with conventional Western medicine to treat cervical erosion patientsleucorrhea increase,Waist acid,The rate of disappearance of abdominal pain and other symptoms is higher than that of pure Western medicine,and the difference is statistically significant(Corpse<0.05. conclusionOur houseSelf-prepared qingre decoction combined with Western medicine treatmentIdegree,IIdegree,IIIdegrees of cervical erosion,has a high cure rate,effect is significant,worth a clinicalpromote.
Matrix Methods: Applied Linear Algebra

Matrix Methods: Applied Linear Algebra, 3e, as a textbook, provides a unique and comprehensive balance between the theory and computation of matrices. The application of matrices is not just for mathematicians. The use by other disciplines has grown dramatically over the years in response to the rapid changes in technology. Matrix methods is the essence of linear algebra and is what is used to help physical scientists; chemists, physicists, engineers, statisticians, and economists solve real world problems. * Applications like Markov chains, graph theory and Leontief Models are placed in early chapters * Readability- The prerequisite for most of the material is a firm understanding of algebra * New chapters on Linear Programming and Markov Chains * Appendix referencing the use of technology, with special emphasis on computer algebra systems (CAS) MATLAB
Multiresolution model generation with geometry and texture

We propose a multiresolution structure for rendering complex objects. The proposed method simplifies complex objects with various color or texture images. We propose a method to make a texture map for the multiresolution model. Our method generates a texture map that can be mapped to the whole level-of-detail in the multiresolution model. The texture map minimizes distortion in the images and it also helps to minimize errors caused by geometric simplification. Furthermore we also propose a multiresolution texture structure to manage texture distortion and texture resolution in a multiresolution manner. The proposed multiresolution structure can manipulate different details for geometry and textures. It can be used in real-time rendering for limited texture and geometric rendering power.
Bacterial vaginosis – a risk factor for preterm labour: a case-control study

Aim: To estimate the prevalence of bacterial vaginosis in preterm labour patients when compared to term labour patients. Materials and Method: It was a hospital based prospective case-control study conducted over a period of two years. Study population was selected as per our study criteria. Speculum examination was done for both control and cases and evaluated for any abnormal vaginal discharge and vaginal pH. Smear from posterior fornix was taken using sterile cotton swabs for wet mount and KOH test (Whiff test). Diagnosis of bacterial vaginosis was made if three of the four signs of Amsel criteria were found. The data were analysed using SPSS software 20 and results were derived. Results: Among the patients bacterial vaginosis was present in 24 of the preterm labour (26.7%) patients and 5 of the term labour (5.6%) patients (Table 1). It was statistically significant (p < 0.001) by Chi-square test. Considering the relative risk(RR), women with bacterial vaginosis has increased risk of preterm labour when compared to patients without bacterial vaginosis(Odds ratio -6.182;RR-4.800). Conclusion: Our study concluded that bacterial vaginosis is one of the most important causes of preterm labour. Routine screening and treatment of bacterial vaginosis for women at high risk for preterm labour will help in reduction of preterm birth related perinatal morbidity and mortality. Keywords: Bacterial vaginosis, Amsel criteria, Preterm labour, Preterm birth, Perinatal morbidity