Miracle-dz/UniFAR-FTUs huggingface dataset:
Muscle imaging analogies in a cohort of patients with different clinical phenotypes caused by LMNA gene mutations

Laminopathies are a heterogeneous group of LMNA‐gene‐mutation–related clinical disorders associated with alterations of cardiac and skeletal muscle and peripheral nerves, metabolic defects, and premature aging. Leg muscle imaging investigations were performed in a cohort of patients with LMNA gene alterations who were suffering from Emery–Dreifuss muscular dystrophy, limb‐girdle muscular dystrophy type 1B, isolated cardiac disorders or a phenotype of cardiac disorders, and lipodystrophy, including one individual with peripheral neuropathy. Leg muscle imaging revealed varying degrees of alteration in the soleus and medial head of gastrocnemius in each subject. This study demonstrates that LMNA‐gene‐mutated patients devoid of any clinically detectable skeletal muscle involvement have the same pattern of leg muscle involvement as patients with overt skeletal muscle compromise. This finding suggests the presence of a continuum of skeletal muscle involvement among phenotypes of LMNA‐gene‐mutation–related skeletalmyopathy and cardiomyopathy. Muscle Nerve, 2010
An Ant Colony Optimization Approach for Maximizing the Lifetime of Heterogeneous Wireless Sensor Networks

Maximizing the lifetime of wireless sensor networks (WSNs) is a challenging problem. Although some methods exist to address the problem in homogeneous WSNs, research on this problem in heterogeneous WSNs have progressed at a slow pace. Inspired by the promising performance of ant colony optimization (ACO) to solve combinatorial problems, this paper proposes an ACO-based approach that can maximize the lifetime of heterogeneous WSNs. The methodology is based on finding the maximum number of disjoint connected covers that satisfy both sensing coverage and network connectivity. A construction graph is designed with each vertex denoting the assignment of a device in a subset. Based on pheromone and heuristic information, the ants seek an optimal path on the construction graph to maximize the number of connected covers. The pheromone serves as a metaphor for the search experiences in building connected covers. The heuristic information is used to reflect the desirability of device assignments. A local search procedure is designed to further improve the search efficiency. The proposed approach has been applied to a variety of heterogeneous WSNs. The results show that the approach is effective and efficient in finding high-quality solutions for maximizing the lifetime of heterogeneous WSNs.
All four-dimensional static , spherically symmetric , two-charge Abelian Kaluza – Klein black holes and their CFT duals

We derive the dual conformal field theory Virasoro algebras from the algebra of conserved diffeomorphism charges for a large class of Abelian Kaluza–Klein black holes. Under certain conditions, such as non-vanishing electric and magnetic monopole charges, the Kaluza–Klein black holes have a Reissner– Nordstrom spacetime structure. For the non-extremal charged Kaluza–Klein black holes, we use the uplifted 6D pure gravity solutions to construct a set of Killing horizon preserving diffeomorphisms. For the (non-supersymmetric) extremal black holes, we take the near-extremal near-horizon (NENH) limit and construct a one-parameter family of diffeomorphisms which preserve the Hamiltonian constraints at spatial infinity. In each case we evaluate the algebra of conserved diffeomorphism charges following Barnich, Brandt and Compère, who used a cohomological approach, and Silva, who employed a covariantLagrangian formalism. At the Killing horizon, it is only Silva’s algebra which acquires a central charge extension and which enables us to recover the Bekenstein–Hawking black hole entropy from the Cardy formula. For the NENH geometry, the extremal black hole entropy is obtained only when the free parameter of the diffeomorphism-generating vector fields is chosen such that the central terms of the two algebras are in agreement. PACS numbers: 04.50. Cd, 04.50. Gh, 04.70. Bw, 11.25. Tq, 11.25. Hf
Analysis of a new type islanding detection method for micro-grid based on the calculation of variance

UL1741 rules that to realize the islanding detection, the inverter must stop running within 2s after the main grid failure occurs. However, with the increasing of the capacity of distributed generation system, in order to guarantee the stability and reliability of power supply simultaneously, IEEE Std.1547 proposed the concept that DG runs off-grid after islanding occurs. The concepts of the traditional islanding protection were attacked, the original islanding detection methods are no longer suitable for the flexible micro power grid operation system. This paper presents a new active islanding detection method which could suitable for micro-grid operation and control. The method, which under the premise of without destroying islanding operation conditions, fine-tunes the PWM modulation wave, real-time acquisition the voltage of point of common coupling, using the mathematical statistics method to extract the quadratic differential of the output voltage, according to the changes of the mathematical characteristic value in the grid connected mode and the islanding mode to judge if there was islanding occurred, and the theory basis of quantitative analysis of the disturbance quantity selection. Simulation and experiment results verify the correctness and feasibility of the proposed method.
Spoken arabic digits recognition based on wavelet neural networks

The paper describes a novel method for discrete speech recognition based on spoken Arabic digit recognition by means of wavelet neural network in which Morlet wavelet is introduced to the hidden layer. The speech signal is extracted by means of Mel Frequency Cepstral Coefficients (MFCCs) and followed by vector quantization (VQ). The experimental results obtained on a spoken Arabic digit dataset proved that it could achieve better accuracy and need less learning time than the proposed method.
Optimization of UHF voltage multiplier circuit for RFID application

This paper presents study and optimization of diode multiplier including antenna matching problems. Results on a voltage multiplier designed in 0.18/spl mu/m CMOS process have been shown. It can power a chip at a distance of 10 m with an efficiency of 30%. In this paper, we present a simple analytical model of the complete tag: antenna and chip. This model allows us to explain many results on crucial points of voltage multiplier design. We also present limitations of this kind of structure.
Factors affecting the voluntary intake of food by cows

The time taken for particles of roughage to be reduced to a size suitable for transfer from the reticulo-rumen to the omasum may be the major factor determining the retention time of roughage residues in the rumen and thereby may partly regulate the voluntary intake of roughage by the cow (Campling, Freer & Balch, 1961, 1962). The size of particles of hay can readily be reduced by grinding. An experiment was conducted, therefore, to examine the effect, on the voluntary intake of hay by cows, of grinding and pelleting the hay, and throughout this report the term ‘ground hay’ will be used to describe the ground, pelleted hay. The cost of grinding and pelleting roughages is high, but there has been some practical interest in the convenience with which the product can be handled. In evaluating this method of preparation, the voluntary intake and utilization of the product must be considered. Several studies have been made of the effects of grinding roughage on the digestibility of the roughage, the time of retention of food residues in the alimentary tract, energy metabolism and animal production (e.g. by Blaxter, Graham & Wainman, 1956; Blaxter & Graham, 1956; Meyer, Gaskill, Stoewsand & Weir, 1959 ; Rodrigue & Allen, 1960). Under certain conditions, grinding roughage appears to exert profound effects on the utilization of diets in which it is included and definition of the critical features in these changes will be an important stage in the understanding of ruminant digestion.
Family behavior therapy for antisocial and narcissistic personality disorders in China: An open study

Background and Objectives: In China, most patients with mental problems are treated outside hospital, and family therapy is a reasonable choice for them. Using variety of skills trainings, it successfully manages Axis I symptoms of the borderline personality disorder sufferers. We therefore conducted an open study by applying this therapy to the patients with antisocial and narcissistic personality disorders and their family members. Methods: Twenty-two out of 50 patients with antisocial, and 14 out of 30 with narcissistic personality disorders completed an eight-session family behavior therapy program. Patients’ Axis I symptoms were measured with a self-reported visual analogue scale, the depressive mood was measured with the Plutchik-van Praag Depression Inventory (PVP), and Axis II personality dysfunctions were measured with the Parker Personality Measure (PERM). Their results before and after the therapy were compared to those obtained in 30 healthy volunteers. Results: After treatment, most self-reported symptoms and PVP scores were significantly lowered in both patient groups. The PERM antisocial T-score in the antisocial group and the PERM narcissistic T-score in the narcissistic group were also significantly decreased. The PERM scale scores were not significantly modified by the treatment in the antisocial group, but some of them were significantly normalized in the narcissistic group. Conclusion: Short-session family behavior therapy could significantly reduce Axis I symptoms in the two groups, and normalize some Axis II dysfunctions in the narcissistic rather than in the antisocial group (German J Psychiatry 2008; 11: 91-97).
Pharmacokinetic and Safety Assessments of Concurrent Administration of Risperidone and Donepezil

Treatment of Alzheimer's disease sometimes uses combinations of drugs because dementia is frequently associated with behavioral symptoms. Risperidone and donepezil are both metabolized through cytochrome P450 2D6 and 3A4, raising the possibility of drug interactions with combination therapy. The objective of this study was to determine whether significant drug interactions occur with concomitant administration of donepezil and risperidone. In an open‐label, three‐way crossover study, 24 healthy men were randomly assigned to receive 0.5 mg of risperidone twice daily, 5 mg of donepezil once daily, or both drugs for 14 consecutive days, followed by a 21‐day washout period. The treatment ratios of AUC and associated 90% confidence intervals (CIs) for risperidone active moiety, defined as risperidone plus 9‐hydroxyrisperidone (ratio = 110.2%; 90% CI = 103.7–117.2), and for donepezil (ratio = 97.1%; 90% CI = 90.0–103.6) were within the 80% to 125% of bioequivalence range. The treatment ratios of Cmax and associated 90% CIs for risperidone active moiety (ratio = 114.6%; 90% CI = 107.0–122.8) and for donepezil (ratio = 96.1%; 90% CI = 90.0–102.6) were also within the bioequivalence range. Therefore, no significant pharmacokinetic differences occurred in either risperidone active moiety or donepezil when given alone or in combination. Adverse events (predominantly headache, nervousness, and somnolence) were minor and comparable for all treatment groups. The results indicate that no clinically meaningful drug interactions occurred between risperidone 1 mg daily and donepezil 5 mg daily at steady state, and therefore no dosage adjustment is required when both drugs are combined with the dosage regimen studied. Additional investigations are warranted to determine the potential for interactions in elderly patients with dementia who may eliminate risperidone and donepezil more slowly and thus be more vulnerable to clinical drug interactions than the young healthy subjects examined in this study.
Protective Effect Of Resveratrol On Oxidative Damage In Male And Female Stroke‐Prone Spontaneously Hypertensive Rats

1. In the present study, we examined the effect of resveratrol (3,4′,5‐trihydroxystilbene), a phytoestrogen found in the skins of most grapes, on oxidative DNA damage in male and female stroke‐prone spontaneously hypertensive rats (SHRSP).
NOVEL THERMAL MICROSENSOR METHOD FOR ONLINE MONITORING OF IN-VITRO BIOFILM FORMATION

A novel sensor principle for continuous monitoring of biofilms is presented. A small heater generates a steady sinusoidal heat signal. The resulting temperature oscillations are measured through a temperature sensor. The amplitude and phase shift of the oscillations are used as sensing parameters. The sensor system successfully detects surface attached bacterial growth within 30 minutes of inoculation. We also show that the sensor enables continuous evaluation of the effect of antibiotics on early stages of biofilm development. Furthermore, the evolution pattern of the signals over time may be useful to differentiate biofilm-forming organisms.
Role of Carcinoma Associated Fibroblasts in Anoikis Resistance in Oral Squamous Cell Carcinoma –need of the hour

Anoikis resistance (AR) is a favorable attribute exhibited by cancer cells for metastasis. Carcinoma associated Fibroblasts (CAFs) plays a crucial role in AR in various cancers. It was proved in array of studies in different cancers that there was defi nite interrelationship between CAFs and AR. But its role in OSCC is ambiguous. It is the need of the time to reveal the correlation of CAF and oral squamous cell carcinoma (OSCC) in relation with anoikis. Molecular pathways which affects the AR via CAFs in various cancers has been highlighted in this communication. Divulging the importance of CAF in cancer will aid in designing customized novel chemoprevention therapy and thus will help in enhancing the prognosis of patient in OSCC. Short Communication
K 2 Router : A Low-Power and High-Performance Router Design for Networks-On-Chip

This paper proposes a new methodology to design of coarse-grained routers in order to improve performance of Networks-on-Chip (NOC). In this approach, several cluster routers in region area of K×K are grouped into one new router called K2Router with similar cost of area and power, however, the performance of whole network is improved. The proposed routers are general in terms of constructions and can be designed and implemented to associate 2×2, 3×3 and 4×4 PEs in a traditional mesh called D2Router, T2Router, and Q2Router, respectively. Based on connections available of such routers, several topologies can be configured. Some of these topologies called DLMesh, DMesh, TLMesh, and QLMesh. Several set of experiments were done on D2Router (k=2), Q2Router (k =4) and O2Router (k=8) with several topologies. The results show that as number of grouped PEs in a K2Router increases, network performance increase dramatically. However, as K increases in K2Router, implementation of the router becomes more complex to use in the network. This is because of wire length in two-dimensional circuit layout, and that would be solved in 3D circuit implementations. Moreover, in the case of using D2Router, the performance, cost and power overhead of DMesh with help of congestion-aware routing algorithm, would be better than those in traditional
Personality and Academic Motivation: Replication, Extension, and Replication.

Previous work examines the relationships between personality traits and intrinsic/extrinsic motivation. We replicate and extend previous work to examine how personality may relate to achievement goals, efficacious beliefs, and mindset about intelligence. Approximately 200 undergraduates responded to the survey with a 150 participants replicating the study two weeks later. When comparing data from the first and second collections, three of the five pathways for personality and achievement goals were replicated: neuroticism, openness, and agreeableness. For personality and efficacy three of the eight pathways remained significant from the first collection to the second. Openness was the only personality factor that significantly predicted participants’ mindset about their intelligence. Results suggest certain personality traits may correspond with different motivational self-beliefs, but these results were neither reliable nor consistent.
An Approach to Photonic Generation of High-Frequency Phase-Coded RF Pulses

A novel method to generate high-frequency phase-coded RF pulses using all-fiber components is proposed. The system consists of a mode-locked fiber laser (MLFL), a dispersive element, an unbalanced Mach-Zehnder interferometer (UMZI), an optical phase modulator (PM), and a photodetector (PD). The PM is incorporated in one arm of the UMZI. In the system, an ultrashort pulse generated by the MLFL is broadened and chirped after passing through the dispersive element, which is then sent to the UMZI, to get two time-delayed chirped pulses. By beating the time-delayed chirped pulses at the PD, an RF pulse with its frequency dependent on the time delay difference is obtained. The generated RF pulse can be phase coded if an encoding signal is applied to the PM. A theoretical model is presented which is verified by experiments. The generation of RF pulses with binary phase coding is also experimented
Environmental impacts of cement production

Будівельна промисловість є одним з лідерів щодо забруднення довкілля внаслідок вичерпування ресурсів і затрат енергії або утворення відходів. Крім того, спостерігається значна емісія від парників, кислотних газів від будівельної промисловості. Цемент належить до одного із найвикористовуваніших будівельних матеріалів у світі, а його виробництво невпинно зростає. А цементна індустрія є дуже енергомісткою. А також продукує велику кількість викидів, отруйних запахів і є дуже шумною. Пил, вуглекислота CO2, оксиди (NOx) азоту і двоокис (SO2) є основними складовими викидів від цементних заводів, що створює великі проблеми. Представлено огляд стану екологічних проблем, пов’язаних з виробництвом цементу в Європі. Building industry is one of the leaders in deterioration of environment by depleting resources and consuming energy or creation of waste. Also a considerable amount of emissions of greenhouse and acidifying gasses has the origin in building industry. Cement belongs to the most often used building materials and its production is increasing over the world. But the cement industry is an energy enormous intensive and products many emissions, odors and noise. The emissions from cement plants which cause greatest concern and which need to be dealt with are dust, carbon dioxide CO2, nitrogen oxides (NOx) and sulphur dioxide (SO2). This paper deals with the review of the main environmental issues related to the cement production in Europe.
Developmental Expression of the Glycine Transporters GLYT1 and GLYT2 in Mouse Brain

Abstract: Using immunocytochemical localization, the distribution of the glycine transporters GLYT1 and GLYT2 in the developing mouse brain was studied. GLYT1 and GLYT2 immunoreactivity begins during the period of fiber outgrow and synaptogenesis. GLYT2 is first expressed in spinal and spinothalamic white matter and is followed by the expression of synaptophysin. In the postnatal stages, GLYT2 staining in the white matter disappears, and a punctuated pattern in the gray matter emerges. In contrast, in the fetal brain GLYT1 immunoreactivity coincides with gray matter neuropil and processes of radial glia. GLYT1 is distributed over a much wider area of the brain than GLYT2. However, the distribution of these two GLYTs implies that GLYT1 and GLYT2 operate in concert within the area where both are present. At the day 12 embryo stage, GLYT1 antibodies stain the liver, and later they also react with the pancreas and the gastroduodenal junction. No other organs exhibit significant GLYT1 immunoreactivity. We additionally observed the presence of GLYT1 in rat fetal cerebral cortex and hippocampus, which was not detected in fetal mouse brain. Moreover, GLYT1 immunoreactivity was found in the mouse floor plate and the ventral commissure but was not present in the same regions in rats. These findings suggest possible differences in the expression of GLYT1 between these two species.
An intelligent agent-mediated Web trading environment

We propose an intelligent agent-mediated trading environment for business-to-consumer transactions. The generic architecture of the system enables it to be used with semistructured product ontologies. The buying behavior model consists of the following fundamental trading agent-mediated stages: product brokering, merchant brokering and negotiation brokering. The product and merchant brokering stages involve three agents: the indexing agent and the retrieval agent, that collaborate through machine learning, text classification techniques and fuzzy logic to match potential buyers with products and merchants, and the profile agent that creates the buyer's profile using his/her relevance feedback. Finally, the negotiation stage includes two transaction agents: the buyer negotiator agent and the merchant negotiator agent, that participate in an auction between the buyers and the "suggested" merchant acting according to the transaction strategies of the buyers and merchant respectively.
Isolation and culture of microvascular endothelial cells from the primate corpus luteum.

Endothelial cells have common as well as specialized roles in different tissues and organs; as such, the abundant endothelial cells in the corpus luteum (> 50% of total cell population) could have unique activities necessary for luteal function. Our objective was to establish a method for isolating a pure population of endothelial cells from the primate corpus luteum and to determine the basic conditions for in vitro culture. Corpora lutea collected from rhesus monkeys throughout the luteal phase of the menstrual cycle were minced and enzymatically dispersed into single cell suspensions. Endothelial cells were isolated from the remaining cells (i.e., steroidogenic, fibroblastic, etc.) utilizing magnetic beads labeled with a lectin, Ulex europaeus agglutinin-1 (UEA-1), which binds a sugar found only on primate endothelial cells. After exposure to a magnetic field, UEA-1-negative (-) cells were decanted from the pelleted UEA-1-positive (+) cells; to remove beads from the UEA-1 (+) cells, excess sugar was applied. After optimization of the bead-to-cell ratio, the UEA-1 (+) group contained a population of cells 8-12 microns in diameter (typical endothelial cell size) and < 1% steroidogenic cells. UEA-1 (-) cells were larger (15-35 microns) and stained histochemically for the steroidogenic marker, 3 beta-hydroxysteroid dehydrogenase. Immunocytochemical analysis demonstrated that > 93% of all cells in the UEA-1 (+) group stained positive for the specific endothelial cell marker, platelet/endothelial cell adhesion molecule-1. Cultured UEA-1 (+) cells produced low levels of progesterone and were unresponsive to hCG (100 ng/ml). In contrast, cultured UEA-1 (-) and mixed (unsorted) cells produced high basal levels of progesterone and exhibited a > 3-fold increase in response to hCG treatment. Preliminary experiments comparing different culture media and matrices demonstrated that 1) cell proliferation was unaffected by type of medium (i.e., Dulbecco's Modified Eagle Medium [DMEM]/ F12 or McCoy's 5A); 2) the presence of serum was essential in the absence of added growth factors, and 3) extracellular matrix had a profound effect on proliferation. UEA-1 (+) cells exhibited a dose-dependent increase in cell proliferation in response to vascular endothelial growth factor (VEGF) in the presence and absence of fetal calf serum. In the absence of serum, VEGF stimulated proliferation of UEA-1 (+) cells plated on fibronectin but not collagen I, whereas in the presence of 10% fetal calf serum, both matrices supported VEGF-induced mitogenesis. These studies provide for the first time an efficient, reliable method for isolating primate luteal endothelial cells and describe in vitro culture conditions for subsequent studies examining luteal endothelial cell function and regulation.