Miracle-dz/UniFAR-FTUs huggingface dataset:
Prototyping of an Individualized Multi-Material Wrist Orthosis using Fused Deposition Modelling

The paper presents the design and manufacturing process of an individualized wrist orthosis. The patient’s upper limb was 3D scanned and the orthosis was designed using a CAD system. Each part of the orthosis consists of two different materials that fulfill different functions. By using the double-head Fused Deposition Modelling machine it was possible to produce these parts in a single process without the need for additional assembly operations. The orthosis has been tested for mutual fit of parts, strength and comfort of use.
Unmet need for chronic mental ill health: A population-based record linkage study

Abstract Introduction Many people with chronic mental ill health do not receive the treatment they require, though the true extent of the associated socio-demographic and socio-economic factors is unknown. Objectives This unique record linkage study quantifies the characteristics of those reporting chronic poor mental health and the likelihood of being in receipt of pharmacological treatment for those who report chronic mental ill health. Methods The Northern Ireland Longitudinal Study (NILS), a random 28% of the 2011 Census returns (aged 25-74), was linked to a population-wide electronic database of prescribed medications. All cohort attributes, including presence of chronic poor mental health were derived from the Census. Logistic regression was used to test the likelihood of people with poor mental health being prescribed psychotropic medication. These findings were compared against similarly derived characteristics of those with respiratory illness on treatment. Results Overall, 23,803 (8.3%) of the enumerated 286,717 reported poor mental health and, while 81.5% received pharmacological treatment, those of non-white background (OR=0.38: 95%CI=0.26-0.54), never married (OR=0.67: 95%CI=061-0.73), unemployed (OR=0.65: 95%CI=0.53-0.81) or living in a rural area (OR=0.88: 95%CI=0.79-0.98) were less likely than their respective peers to receive medication for poor mental health. Non-treatment of respiratory illness was less socially patterned. Conclusions Some but not all of the observed variation in receipt of psychotropic medicines may represent unmet need. Further studies are required to clarify the patterning of and possible reasons for underuse, including understanding of and attitudes towards healthcare services of groups who are identified as being less likely to receive treatment (for example ethnic minorities and unemployed). Highlights Self-reported chronic mental ill health varied by socio-demographic and socio-economic characteristics. Although a high proportion of people received psychotropic medication for their mental ill health, there were evident social patterns among those who do not receive treatment. Ethnic minorities, those whose were not married or unemployed were considerably more likely to experience unmet need.
A simulation-based method to determine the coefficient of hyperbolic decline curve for tight oil production

Tight oil reservoirs are characterized by the ultra low porosity and permeability, making it a great challenge to enhance oil production. Owing to the fast development in hydraulic fracturing technology of horizontal wells, tight oil has been widely explored in North America. Individual wells have a long term of low production after a rapid production decline. This causes low cumulative production in tight oil reservoirs. A rate decline curve is the most common method to forecast their production rates. The forecast can provide useful information during decision making on future development of production wells. In this paper, a relationship is developed between the parameters of a hyperbolic decline curve and the reservoir/fracture properties when a reservoir simulation model is used based on the data from a real field. Understanding of this relationship improves the application of the hyperbolic decline curve and provides a useful reference to forecast production performance in a more convenient and efficient way. Cited as : Yu, Y. , Chen, Z. , Xu, J. A simulation-based method to determine the coefficient of hyperbolic decline curve for tight oil production. Advances in Geo-Energy Research, 2019, 3(4): 375-380, doi: 10.26804/ager.2019. 04.04.
Location-Aware Query Reformulation for Search Engine

Query reformulation, including query recommendation and query auto-completion, is a popular add-on feature of search engines, which provide related and helpful reformulations of a keyword query. Due to the dropping prices of smartphones and the increasing coverage and bandwidth of mobile networks, a large percentage of search engine queries are issued from mobile devices. This makes it possible to improve the quality of query recommendation and auto-copmpletion by considering the physical locations of the query issuers. However, limited research has been done on location-aware query reformulation for search engines. In this paper, we propose an effective spatial proximity measure between a query issuer and a query with a location distribution obtained from its clicked URLs in the query history. Based on this, we extend popular query recommendation and auto-completion approaches to our location-aware setting, which suggest query reformulations that are semantically relevant to the original query and give results that are spatially close to the query issuer. In addition, we extend the bookmark coloring algorithm for graph proximity search to support our proposed query recommendation approaches online, and we adapt an A* search algorithm to support our query auto-completion approach. We also propose a spatial partitioning based approximation that accelerates the computation of our proposed spatial proximity. We conduct experiments using a real query log, which show that our proposed approaches significantly outperform previous work in terms of quality, and they can be efficiently applied online. †The University of Hong Kong E-mail: {zphuang, yqqian}@cs.hku. hk ‡University of Ioannina E-mail: nikos@cs.uoi. gr 2 Zhipeng Huang† et al.
Glomerular Filtration Evaluation Employing Serum Cystatin C Measurement

An accurate evaluation of renal function with glomerular filtration rate (GFR) measurement is essential in clinical practice, as it defines diagnostic and therapeutic decisions. Serum creatinine is the most utilized method. However, it has several limitations, such as the influence of drugs and endogenous substances on its measurement, and a low sensitivity for detecting less advanced degrees of renal dysfunction. Other well-known methods, such as the clearances of insulin, iohexol, 125I-iothalamate, and 51Cr-EDTA have also been employed with the same purpose; however, these methods can be complex and expensive. Therefore, investigators are still searching for simpler markers to analyze renal function. Cystatin C, an endogenous substance, has been described as a reliable and easy-to-perform indicator of GFR. Cystatin C is a member of the family of cystein protease inhibitors and is constantly produced by nucleated cells. Its measurement, when compared to creatinine, suffers less interference and is more accurate for the detection of incipient decreases of renal function. The aim of this review is to analyze the details of cystatin C measurement, such as reference values and clinical application. (J Bras Nefrol
S0033291719003155jra 1..10

Background. The Green et al., Paranoid Thoughts Scale (GPTS) – comprising two 16-item scales assessing ideas of reference (Part A) and ideas of persecution (Part B) – was developed over a decade ago. Our aim was to conduct the first large-scale psychometric evaluation. Methods. In total, 10 551 individuals provided GPTS data. Four hundred and twenty-two patients with psychosis and 805 non-clinical individuals completed GPTS Parts A and B. An additional 1743 patients with psychosis and 7581 non-clinical individuals completed GPTS Part B. Factor analysis, item response theory, and receiver operating characteristic analyses were conducted. Results. The original two-factor structure of the GPTS had an inadequate model fit: Part A did not form a unidimensional scale and multiple items were locally dependant. A Revised-GPTS (R-GPTS) was formed, comprising eight-item ideas of reference and 10-item ideas of persecution subscales, which had an excellent model fit. All items in the new Reference (a = 2.09–3.67) and Persecution (a = 2.37–4.38) scales were strongly discriminative of shifts in paranoia and had high reliability across the spectrum of severity (a > 0.90). The R-GPTS score ranges are: average (Reference: 0–9; Persecution: 0–4); elevated (Reference: 10–15; Persecution: 5–10); moderately severe (Reference: 16–20; Persecution:11–17); severe (Reference: 21–24; Persecution: 18–27); and very severe (Reference: 25+; Persecution: 28+). Recommended cut-offs on the persecution scale are 11 to discriminate clinical levels of persecutory ideation and 18 for a likely persecutory delusion. Conclusions. The psychometric evaluation indicated a need to improve the GPTS. The R-GPTS is a more precise measure, has excellent psychometric properties, and is recommended for future studies of paranoia.
Filtragem Automática de Spam nos Comentários do YouTube

Resumo—A exploração de um nicho inédito e a rentabilidade promovida pelo Google vêm atraindo um enorme e crescente número de usuários para sua plataforma de compartilhamento de vı́deos, chamada YouTube. Contudo, esse sucesso também vem despertando a atenção de usuários mal-intencionados, que buscam autopromoção através de comentários e vı́deos indesejados, muitas vezes disseminando links maliciosos que podem propagar vı́rus e malwares. Uma vez que o YouTube atualmente oferece recursos limitados para bloquear spam, o volume dessas mensagens está aumentando de forma desenfreada e muitos usuários e donos de canais já estão sentindo e reportando o impacto negativo gerado por esse conteúdo indesejado. Filtrar spam nos comentários do YouTube é uma tarefa que difere-se bastante da tradicional filtragem de spam em e-mails, pois as mensagens costumam ser muito mais curtas e repletas de gı́rias, sı́mbolos e abreviações que dificultam a tarefa de classificação. Neste trabalho, são analisados os desempenhos de métodos tradicionais de classificação quando aplicados na filtragem automática de comentários indesejados no YouTube. Com grau de confiança de 99%, a análise dos resultados indica que os métodos SVM Linear, SVM RBF, Naı̈ve Bayes Bernoulli e Regressão Logı́stica obtiveram desempenhos estatisticamente equivalentes.
Progress in managing the transition from the RS92 to the Vaisala RS41 as the operational radiosonde within the GCOS Reference Upper-Air Network

Abstract. This paper describes the GRUAN-wide approach to manage the transition from the Vaisala RS92 to the Vaisala RS41 as the operational radiosonde. The goal of the GCOS Reference Upper-Air Network (GRUAN) is to provide long-term high-quality reference observations of upper air Essential Climate Variables (ECVs) such as temperature and water vapor. With GRUAN data being used for climate monitoring, it is vital that the change of measurement system does not introduce inhomogeneities in to the data record. The majority of the 27 GRUAN sites were launching the RS92 as their operational radiosonde, and following the end of production of the RS92 in the last quarter of 2017, most of these sites have now switched to the RS41. Such a large-scale change in instrumentation is unprecedented in the history of GRUAN and poses a challenge for the network. Several measurement programmes have been initiated to characterize differences in biases, uncertainties and noise between the two radiosonde types. These include laboratory characterization of measurement errors, extensive twin sounding studies with RS92 and RS41 on the same balloon, and comparison with ancillary data. This integrated approach is commensurate with the GRUAN principles of traceability and deliberate redundancy. A two-year period of regular twin soundings is recommended, and for sites that are not able to implement this burden sharing is employed, such that measurements at a certain site are considered representative of other sites with similar climatological characteristics. All data relevant to the RS92-RS41 transition are archived in a database that will be accessible to the scientific community for external scrutiny. Furthermore, the knowledge and experience gained about GRUAN's RS92-RS41 transition will be extensively documented to ensure traceability of the process. This documentation will benefit other networks in managing changes in their operational radiosonde systems. Preliminary analysis of the laboratory experiments indicates that the manufacturer's calibration of the RS41's temperature and humidity sensors is more accurate than for the RS92; with uncertainties of
Effect of Substitution of Urea With Different Type and Levels of Ruminant Manure on Nutritive Value of Rice Straw Silage

This study was conducted in Nutrition Lab. to investigate the effect of the type and level of substitution of urea with ruminant manure, M (sheep, cow and buffalo) on basis of nitrogen (N) content on the nutritive value of rice straw silage (RSS). Accordingly silages were nominated as, S-RSS, C-RSS and B-RSS. Urea (U) was substituted with dried manure at 6 combinations, 100:0, 90:10, 80:20, 70:30, 60:40 and 50:50 of U:M. Silage samples were prepared by treating chopped straw with pre-treated solution contained 10% low quality debis and 2% urea. Results showed that lower (P˂0.01) DM loss (11.4%) was observed in S-RSS, and with addition of urea only (3.6%). Samples of S-RSS and C-RSS recorded higher (P˂0.01) Fleig points (Fp) as compared with those prepared by the addition of B-RSS, 60.42, 55.58 and 49.59 respectively. Reduction (P˂0.01) in this parameter was noticed in samples prepared with a combination of 100:0. Aerobic stability (AS) was a reduced (P˂0.01) in samples prepared by addition of S-RSS by 15 and 13 hours in comparison with samples of C-RSS and B-RSS respectively. Samples prepared with combination of 100:0 were prior (P˂0.01) as compared with other samples. Results also showed an increase (P˂0.01) in in vitro digestibility of organic matter (IVOMD) in samples of S-RSS in comparison with samples prepared by addition of C-RSS and B-RSS, 49.99, 44.59 and 42.77% respectively. Samples prepared with combination of 100:0 recorded lower (P˂0.05) in vitro digestibility of dry matter (IVDMD) as compared with combinations of 70:30 and 60:40 of U: M, 40.52, 45.36 and 45.94% respectively.
A silent outbreak due to Klebsiella pneumoniae that co-produced NDM-1 and OXA-48 carbapenemases, and infection control measures

Objective(s): Infections due to carbapenemase-producing Klebsiella pneumoniae are associated with high morbidity and mortality. In this study, we report a hospital outbreak due to co-producing OXA-48 and NDM-1 K. pneumoniae clone. The aim of the study is to investigate the clonal relationship of strains, risk factors of outbreak and infection control measures. Materials and Methods: Once an outbreak was suspected at the end of December 2017 in our intensive care unit (ICU), carbapenem resistance K. pneumoniae identified in patients’ specimens. An outbreak analysis was begun to determine the risk factors and dissemination of the cases. A case-control study was conducted to determine the risk factors. To control the outbreak; tight contact prevention, good clean-up the medical devices and hospital environment, were done. Staff training programs such as hand hygiene, disinfection, wearing aprons, good cleaning were created. Carbapenem resistance genes determined by PCR. Clonal relationships of strains investigated by PFGE. Results: We investigate 21 carbapenem-resistant K. pneumonia strains. Nine of them were found co-produced NDM-1 and OXA-48, 11 strains produced OXA-48, and one strain produced NDM-1. Seven strains of co-producing NDM-1 and OXA-48 were found clonally related with PFGE. We could not determine any risk factor except rectal colonization in the case-control study. Conclusion: The interventions that successfully controlled this outbreak were hand hygiene, tight contact prevention, good clean-up of the hospital environment and medical devices. As a result, we believe that it would be beneficial to take infection control measures to prevent the spread of these strains to the community and hospital settings.
The Topo-Speech Algorithm: An intuitive Sensory Substitution for Spatial Information

Is it possible to quickly and reliably understand the position of objects in space without vision? This is one of the biggest challenge blind people face daily. We developed a novel algorithm called the Topo-Speech which conveys the spatial position of objects via speech manipulations. We ran a pilot study on blindfolded sighted adults (n=5) to test the extent to which users can locate objects’ spatial positions after short training with the Topo-Speech, as well as their ability to locate untrained spatial positions. Participants were trained for ~30 minutes on the detection of objects’ positions on a 3×3 grid. Then they were tested on the same spatial locations (though using different stimuli). Finally, participants were tested on identifying the positions of objects on a 5×5 grid (i.e. additional spatial locations) without any specific training. Our results showed that participants performed significantly above chance for both trained and untrained spatial positions. This in turn suggests the feasibility of the Topo-Speech to convey spatial related information via a non-visual channel and prompt to quickly test such approach with people who are visually impaired.
ADVANCED JOURNAL OF EMERGENCY MEDICINE. 2020;*(*): e*

Having an extremely toxic compound for humans and most animals, paraquat (PQ) is known as one of the most frequently used herbicides. Accordingly, PQ poisoning has been recognized as a serious medical problem across the world, with a severe case fatality rate (CFR) (1, 2). In this respect; accidental or intentional ingestion of PQ, even in a small amount, can be significantly associated with poor clinical prognosis and increased mortality. Moreover; inherent toxicity of PQ, absence of specific antidotes, as well as lack of effective treatments have been principally attributed to high fatality of PQ poisoning. Once PQ is ingested, it can be absorbed through skin and the digestive and respiratory system and often progresses to multiorgan failure, particularly the lungs as the main target. In this respect, PQ accumulates predominantly in the lungs and can lead to lung fibrosis, pneumonitis, and consequently respiratory failure and death (2, 3). Given the nonexistence of specific and widely accepted guidelines for treatment of PQ poisoning, a range of conservative therapeutic modalities have been proposed and administered by clinicians to moderate PQ absorption and to prevent organ failure in these patients. In spite of this, PQ-induced mortality rate is high and disappointing (1, 3).
ComboDroid: Generating High-Quality Test Inputs for Android Apps via Use Case Combinations

Android apps demand high-quality test inputs, whose generation remains an open challenge. Existing techniques fall short on exploring complex app functionalities reachable only by a long, meaningful, and effective test input. Observing that such test inputs can usually be decomposed into relatively independent short use cases, this paper presents ComboDroid, a fundamentally different Android app testing framework. ComboDroid obtains use cases for manifesting a specific app functionality (either manually provided or automatically extracted), and systematically enumerates the combinations of use cases, yielding high-quality test inputs. The evaluation results of ComboDroid on real-world apps are encouraging. Our fully automatic variant outperformed the best existing technique APE by covering 4.6% more code (APE only outperformed Monkey by 2.1%), and revealed four previously unknown bugs in extensively tested subjects. Our semi-automatic variant boosts the manual use cases obtained with little manual labor, achieving a comparable coverage (only 3.2% less) with a white-box human testing expert.
A System Dynamics model to explore Strategy Renewal Process in Family Firms

The aim of the paper is to investigate strategy renewal process inside family firms characterised by a top management team that includes family members belonging to two different generations. In particular we are interested in understanding how the strategy renewal process can be affected by dynamic tensions that emerge between representatives of different generations: young and senior members of the top management team. To address our topic we built, grounding on relevant literature, a System Dynamic process model. The elaboration of our theory was supported by System Dynamics logical-analytical tools [Forrester, 1961, 1968]: the use of the feedback concept and the distinction between stock and flow variables [Sterman, 2000]. We think that the use of SD will contribute to enhance internal consistency in theoretical models as well as it allows to analyse the temporal evolution of strategic choices and the dynamic links between organization, resources and strategic positioning. Long-term effects coming from decision-making process dynamics are particularly relevant for family businesses as these organisation forms tend to be more longterm oriented than non-family firms having their raison-d’être in the family-firm continuity across generations. The paper is structured as follow: the first session is dedicated to the definition of the strategy renewal process and to describe the model. The second part is dedicated to the analysis of critical resources and organizational attributes that determine the strategy renewal process. In the third part we discuss main feedback loop structure of the model.