Miracle-dz/UniFAR-FTUs huggingface dataset:
On the relationship of anthranilic derivatives structure and the FXR (Farnesoid X receptor) agonist activity

Farnesoid X receptor (FXR) is a nuclear receptor related to lipid and glucose homeostasis and is considered an important molecular target to treatment of metabolic diseases as diabetes, dyslipidemia, and liver cancer. Nowadays, there are several FXR agonists reported in the literature and some of it in clinical trials for liver disorders. Herein, a compound series was employed to generate QSAR models to better understand the structural basis for FXR activation by anthranilic acid derivatives (AADs). Furthermore, here we evaluate the inclusion of the standard deviation (SD) of EC50 values in QSAR models quality. Comparison between the use of experimental variance plus average values in model construction with the standard method of model generation that considers only the average values was performed. 2D and 3D QSAR models based on the AAD data set including SD values showed similar molecular interpretation maps and quality (Q2LOO, Q2(F2), and Q2(F3)), when compared to models based only on average values. SD-based models revealed more accurate predictions for the set of test compounds, with lower mean absolute error indices as well as more residuals near zero. Additionally, the visual interpretation of different QSAR approaches agrees with experimental data, highlighting key elements for understanding the biological activity of AADs. The approach using standard deviation values may offer new possibilities for generating more accurate QSAR models based on available experimental data.
Barriers to Women's Cardiovascular Risk Knowledge

Cardiovascular disease (CVD) is the leading cause of death for women in the United States, resulting in a greater emphasis on research and methods for addressing issues relating to this health problem both nationally and worldwide. The authors’ purpose was to identify barriers to women's cardiovascular risk knowledge, both personal and organizational, through key informant interviews of health leaders at 10 community health organizations. Analysis showed an overall lack of awareness of CVD risk for women. Culture, finance, and lack of awareness and easily accessible programs implicated the importance of physicians as health care providers and educators for women patients.
“Can It Be That God Does Not Remember Me”: A Qualitative Study on the Psychological Distress, Suffering, and Coping of Dominican Women With Chronic Filarial Lymphedema and Elephantiasis of the Leg

The psychological states of Dominican women with chronic lymphedema and elephantiasis of the leg and the coping strategies they used to ameliorate the negative psychological effects of this condition were explored using modified precepts of grounded theory method. Qualitative data were gathered through in-depth interviewing and focus group discussions held in the Dominican Republic. Thematic results found that compounding their physical disfigurement, functional limitations, and social losses were feelings of depression, embarrassment, social isolation, and despair. Adaptive problem solving and emotion-focused coping strategies that emerged during analysis also are discussed. It is recommended that management of psychological distress should be a significant component of lymphedema management programs in developing countries.
Identifying Children with Developmental Disabilities Receiving Child Protection Services: A National Survey of Child Welfare Administrators

The purpose of this study was to examine the ability of U.S. state child protection service (CPS) agencies to identify children with developmental disabilities who have been maltreated and provide them with services to meet their unique needs. The subjects were 50 state-level child welfare administrators (including the District of Columbia) who were knowledgeable about the data collections requirements in their states. The findings of this study are presented and compared with data collected from two previous studies. Findings indicate that less than one-half of state child welfare agencies identify children with developmental disabilities. The implications of the findings highlight the need for improved data collection procedures, staff and foster care family training regarding disabilities, and improved collaboration with traditional developmental disability-related providers.
Deep Pelvic Anatomy Revisited for a Description of Crucial Steps in Extralevator Abdominoperineal Excision for Rectal Cancer

BACKGROUND: Extralevator abdominoperineal excision results in superior oncologic outcome for advanced low rectal cancer. The exact definition of surgical resection planes is pivotal to achieving negative circumferential resection margins. OBJECTIVE: This study aims to describe the surrounding anatomical structures that are at risk for inadvertent damage during extralevator abdominoperineal excision. DESIGN AND SETTING: Joint surgical and macroanatomical dissection was performed in a university laboratory of clinical anatomy. METHODS: A stepwise dissection study was conducted according to the technique of extralevator abdominoperineal excision by abdominal and perineal approaches in 4 human cadaveric pelvises. Muscular, fascial, tendinous, and neural structures were carefully exposed and related to the corresponding surgical resection planes. RESULTS: In addition to the autonomic nerves to be identified and preserved during total mesorectal excision, further structures endangered during extralevator abdominoperineal excision can be clearly identified. Terminal pudendal nerve branches come close to the surgical resection plane at the outer surface of the puborectal sling. Likewise, the pelvic plexus and its neurovascular bundles embedded within the parietal pelvic fascia extend close to the apex of the prostate where the parietal pelvic fascia has to be divided. These neural structures converge in the region of the perineal body, an area that provides no “self-opening” planes for surgical dissection. Thus, the necessity to sharply detach the anorectal specimen anteriorly from the perineal body and the superficial transverse perineal muscle bears the risk of both inadvertent damage of the aforementioned anatomical structures and perforation of the specimen. LIMITATIONS: The study focused primarily on the macroscopic topography relevant to the surgical procedure, so that previously published histologic examinations were not performed. CONCLUSION: The present anatomical dissection study highlights those anatomical landmarks that require clear identification for the successful achievement of both negative circumferential resection margins and preservation of urogenital functions during extralevator abdominoperineal excision.
Experiences Accompanying Postpartum Weight Loss: Benefits, Successes, and Well-Being

Obesity is a growing problem in the United States, and research has supported the theory that pregnancy contributes to long-term weight gain. This phenomenological study investigated the postpartum weight loss experiences of 24 women. Women ranged in age from 25 to 35 years, were mostly Caucasian with adequate resources, and about half worked either full or part time. Women described both positive and negative experiences associated with weight loss. Themes included issues related to exercise, weight struggles, pregnancy contributions to weight gain, eating, breastfeeding, motivation for weight loss, time issues, miscellaneous struggles, realizing benefits, social support, quick weight loss, personal well-being, and successes. The overarching theme that represents these women's experiences was the need to balance weight loss activity with other responsibilities, which resulted in challenges and triumphs in women's pursuit of returning to their prepregnancy weights. Realizing benefits, successes, and personal well-being are addressed in this article.
Assumed infectiousness, treatment adherence and sexual behaviours: applying the Swiss Statement on infectiousness to HIV‐positive alcohol drinkers

The success of antiretroviral therapy (ART) for treating HIV infection is now being turned towards HIV prevention. The Swiss Federal Commission for HIV/AIDS has declared that HIV‐positive persons who are treated with ART, have an undetectable viral load, and are free of co‐occurring sexually transmitted infections (STIs) should be considered noninfectious for sexual transmission of HIV. This study examined the implications of these assumptions in a sample of HIV‐positive individuals who drink alcohol.
Changing Bodies, Changing Habits: Women's Experiences of Interval Training Following Gastric Bypass Surgery

Patients undergoing weight-loss surgery are increasingly encouraged to change their lifestyles. Dietary interventions combined with physical exercise interventions are regarded as the most effective way to ensure that they do not regain the weight they have lost. Little research however, has been done on how patients who have had the surgery actually experience the process of changing their exercise habits. To help fill this gap, we investigated the experiences of women participating in a group-based rehabilitation program designed to radically transform these habits. Based on participant observation, and our interviews with 11 women in the program, we were able to identify a variety of potential benefits and negative consequences in group training, organized according to the interval principle. We also found that the experiences of these women were closely related to their views on how significantly the surgery had changed their lifestyle. Based on the experiences related by these women, we believe that the “effectiveness” of standardized group-based interventions for patients undergoing weight-loss surgery should be reconsidered. Some of the women in our study viewed the group-based standardized training intervention positively; others resisted it. Our research leads us to conclude that this type of program could be more successful if the forms of activity and their intensity were customized to meet the needs and desires of each participant.
Knowledge, Attitudes, and Practices Associated With Menopause: A Multi-ethnic, Qualitative Study in Singapore

We explored knowledge, attitudes, and practices associated with the menopause transition particular to women in the multi-ethnic cultural context of Singapore. Fifty-eight Chinese, Malay, and Indian Singaporean women participated in interviews that were audiorecorded, transcribed verbatim, and analyzed using thematic analysis. Women from all three ethnicities described an attitude of acceptance surrounding menopause and the changes associated with it. While they thought it was important to be informed, they did not seek out information about menopause and did not view health professionals as useful sources of information. Management practices were diverse and rarely involved accessing health professionals.
Orthovoltage Intraoperative Radiotherapy for Locally Advanced and Recurrent Colorectal Cancer

BACKGROUND: Locally advanced and recurrent colorectal cancers pose a significant therapeutic challenge. Orthovoltage intraoperative radiotherapy provides one potential means of improving disease control at the time of surgery. OBJECTIVE: This study sought to analyze outcomes and identify prognostic factors of patients treated with orthovoltage intraoperative radiotherapy for locally advanced or recurrent colorectal cancer. DESIGN AND SETTING: This study is a retrospective chart review conducted at a tertiary medical center. PATIENTS: Between January 1990 and July 2009, 55 patients underwent intraoperative radiotherapy to a total of 61 sites for locally advanced (n = 14) or recurrent (n = 41) cancers of colon (n = 18) or rectum/rectosigmoid junction (n = 37). INTERVENTIONS: Median dose was 12 Gy (range, 7.5–20 Gy). Among locally advanced rectal/rectosigmoid cases, surgery included abdominoperineal resection (n = 3) or low anterior resection (n = 9). Seven treated sites had gross residual (R2) disease, 28 had pathologic or clinical microscopic residual disease (R1), and 15 were complete resections (R0). Treated sites included sacrum (n = 22), anterior pelvis/pelvic sidewall (19), sacrum and sidewall (n = 1), aortic bifurcation (n = 2), vaginal cuff (n = 2), psoas (n = 3), perivesicular region (n = 2), and other (n = 10). MAIN OUTCOMES MEASURES: Outcomes measures included in-field local control, locoregional control, overall survival, and grade ≥3 toxicity. RESULTS: At a median follow-up of 27 months (range, 4–237) among living patients, 2-year Kaplan-Meier estimates of in-field local control, locoregional control, and overall survival were 69%, 51%, and 59%. Margin status predicted for improved locoregional control (p = 0.01) and overall survival (p = 0.01). Seventeen patients (31%) developed a grade 3 to 5 toxicity following surgery with intraoperative radiotherapy. LIMITATIONS: This study was limited by its retrospective nature and relatively small sample size. CONCLUSIONS: Local control with intraoperative radiotherapy for locally advanced and recurrent colorectal cancers is good despite the high risk of residual disease. Among carefully selected patients, multimodality regimens including intraoperative radiotherapy may permit long-term survival.
Pletismografia respiratória por indutância: estudo comparativo entre calibração por manobra de isovolume e calibração qualitativa diagnóstica em voluntários saudáveis avaliados em diferentes posturas

OBJECTIVE: To compare two methods of respiratory inductive plethysmography (RIP) calibration in three different positions. METHODS: We evaluated 28 healthy subjects (18 women and 10 men), with a mean age of 25.4 ± 3.9 years. For all of the subjects, isovolume maneuver calibration (ISOCAL) and qualitative diagnostic calibration (QDC) were used in the orthostatic, sitting, and supine positions. In order to evaluate the concordance between the two calibration methods, we used ANOVA and Bland-Altman plots. RESULTS: The values of the constant of proportionality (K) were significantly different between ISOCAL and QDC in the three positions evaluated: 1.6 ± 0.5 vs. 2.0 ± 1.2, in the supine position, 2.5 ± 0.8 vs. 0.6 ± 0.3 in the sitting position, and 2.0 ± 0.8 vs. 0.6 ± 0.3 in the orthostatic position (p < 0.05 for all). CONCLUSIONS: Our results suggest that QDC is an inaccurate method for the calibration of RIP. The K values obtained with ISOCAL reveal that RIP should be calibrated for each position evaluated.
Paraneoplastic myasthenia gravis: immunological and clinical aspects

Paraneoplastic myasthenia gravis (MG) is accompanied by a neoplasm, usually thymoma. In patients with thymoma and a specific genetic make‐up, the paraneoplastic immune response develops further in thymic remnant or peripheral lymphatic tissue. Paraneoplastic MG and late‐onset MG (age ≥ 50 years) share a similar immunological profile with high titin and ryanodine receptor (RyR) antibody prevalence. This profile is the most important predictor of clinical outcome in paraneoplastic MG. The presence of a thymoma per se does not cause more severe MG. MG severity is linked to the patient’s immunological profile. Paraneoplastic MG causes a distinctive non‐limb symptom profile at MG onset, characterized by bulbar, ocular, neck, and respiratory symptoms. When the diagnosis of paraneoplastic MG is established, the neoplasm should be removed surgically. Pre‐thymectomy plasmapheresis or iv‐IgG should be considered in these patients to minimize post‐thymectomy MG exacerbation risk. Paraneoplastic MG usually continues after thymectomy. The pharmacological treatment of paraneoplastic MG does not differ from non‐paraneoplastic MG, except for tacrolimus that should be considered in difficult cases. Tacrolimus is an immunosuppressant acting specifically in RyR antibody positive patients through enhancing RyR‐related sarcoplasmic calcium release that in theory might be blocked by RyR antibodies, causing symptomatic relief in paraneoplastic MG.
Sociocultural and structural perpetuators of domestic violence in pregnancy: A qualitative look at what South Indian women believe needs to change

ABSTRACT In India, reported rates of domestic violence rise as high as 31%. Abuse against pregnant women in India is associated with depressive and PTSD symptoms, and poor birth outcomes, yet no evidence-based interventions have been tested on this population. In this cross-sectional qualitative study, we sought perspective on South Indian women's concerns about abuse during pregnancy and what they believed would help. Participants cited economic dependence on husbands and sociocultural structures as factors perpetuating domestic violence. Women also described resilience factors that can protect against abuse. Our participants highlighted a requisite for interventions within health and social systems.
Quantitative evaluation of functional limitation of upper limb movements in subjects affected by ataxia

Background and purpose: The design of useful and effective treatment strategies for movement disorders largely depends on the ability to objectively quantify changes in performances, providing reliable outcome measures. Evaluation of ataxia remains mainly assigned to different clinical scales, providing a semi‐quantitative assessment. The aim of this study was to quantitatively characterize functional changes in upper limb movements in ataxic patients, using an optoelectronic system for objective measurements.
Introduction: Aging and the Multifaceted Influences on Adaptation to Working Time

This special issue of Chronobiology International presents a selection of papers originally delivered at the 18th International Symposium on Shift Work and Working Time, held at Yeppoon, Australia, in August 2007. The key theme of the symposium was “Aging and Working Time: Creating Safe Environments. ” Older workers are widely believed to experience greater difficulty than younger workers adapting to shift work and irregular work schedules. However, while the three reviews of age effects published here (Costa & Di Milia, ; Folkard, ; Gander & Signal, ) identify evidence that older workers do indeed adapt less well, they also demonstrate that much more research is urgently required. The remaining papers address various aspects of the impact of work schedules on health, safety, sleep, and performance. They can be divided into three broad categories: circadian and other periodic factors; sleep, sleepiness, and fatigue; and other aspects of health and adjustment. This collection of papers showcases the best of contemporary research on the safety and health effects of working hours, continuing the tradition established by the two previous issues of the journal devoted to earlier symposia on shift work and working time.
Diurnal Variation of Plasma Brain‐Derived Neurotrophic Factor (BDNF) in Humans: An Analysis of Sex Differences

Scant information is available on the diurnal variation of peripheral neurotrophic factors, including brain‐derived neurotrophic factor (BDNF), in human beings. We explored plasma and serum BDNF levels at three different clock times in a study of 28 healthy subjects of both sexes. Statistically significant diurnal variation in plasma BDNF level was detected in men, with the peak at 08:00 h and nadir at 22:00 h. At this time, the plasma BDNF concentration of men was significantly lower than that of women (p=.02). However, no diurnal variation was found either in plasma BDNF of women, in either the follicular or luteal phases of the menstrual cycle, or in serum BDNF level in both men and women. These findings support the concept of rhythmic variation in plasma BDNF regulation that seems to be sex‐related. (Author correspondence: dmarazzi@psico.med.unipi.it)
60 A comparison of HFrEF vs HFpEF’s clinical workload and cost in the first year following hospitalisation and enrollment in a disease management program

Background Admission with heart failure (HF) is a milestone in the progression of the disease, often resulting in higher intensity medical care and ensuing readmissions. Whilst there is evidence supporting enrolling patients in a heart failure disease management program (HF-DMP), not all reported HF-DMPs have systematically enrolled patients with HF with preserved ejection fraction (HFpEF) and there is a scarcity of literature differentiating costs based on HF-phenotype. Methods 1292 consenting, consecutive patients admitted with a primary diagnosis of HF were enrolled in a hospital based HF-DMP and categorised as HFpEF (EF ≥ 45%) or HFrEF (EF < 45%). Hospitalizations, primary care, medications, and DMP workload with associated costs were evaluated assessing DMP clinic visits, telephonic contact, medication changes over 1 year using a mixture of casemix and micro-costing techniques. Results The total average annual cost per patient was marginally higher in patients with HFrEF €13,011 (12011, 14078) than HFpEF, €12206 (11009, 13518). However, emergency non-cardiovascular admission rates and average cost per patient were higher in the HFpEF vs HFrEF group (0.46 vs 0.31 per patient/12 months). In the first 3 months of the outpatient HF-DMP the HFrEF population cost more on average €791(764,819) vs €693(660,728). Conclusion There are greater short-term (3 month) costs of HFrEF versus HFpEF as part of a HF-DMP following an admission. However, long-term (3–9 month) costs of HFpEF are greater because of higher non-cardiovascular rehospitalisations. As HFpEF becomes the dominant form of HF, more work is required in HF-DMPs to address non-cardiovascular rehospitalisations and to integrate hospital based HF-DMPs into primary healthcare structures.
Pregnancy Increases Median Nerve Susceptibility to Lidocaine

To determine whether pregnancy renders women more sensitive to local anesthetics, nine nonpregnant and nine pregnant (third trimester) women underwent median nerve block at the wrist using 1% lidocaine HCl. Inhibition of median nerve A alpha sensory and motor fibers was assessed using measurements of sensory nerve action potential (SNAP) amplitude and compound motor action potential (CMAP) amplitude, respectively. Inhibition of median nerve C fibers was assessed by the increase in skin temperature and by the decrease in median (relative to ulnar) galvanic skin potential (GSP) amplitude. Lidocaine inhibited SNAP to a greater extent in pregnant than nonpregnant women at all time points (P = 0.019). CMAP declined differently in the pregnant and nonpregnant groups (P = 0.01): the pregnant subjects achieved steady state inhibition before the nonpregnant subjects. The two groups developed comparable steady state inhibition. Skin temperature was higher in pregnant women at all time points (P less than 0.0001); moreover, the increased skin temperature of pregnant women differed from that of the nonpregnant women (P = 0.037), reflecting a more rapid temperature increase in the pregnant women. GSP amplitude declined to 50% of control more rapidly in pregnant (mean = 4 min) than nonpregnant women (mean = 11.5 min), but these differences did not achieve statistical significance. It is concluded that pregnancy increases median nerve susceptibility to lidocaine.