Miracle-dz/UniFAR-FTUs huggingface dataset:
Der Einfluss unterschiedlicher Mikroskope auf die Applikationsgenauigkeit bei elekromagnetischer Navigation an der Schädelbasis

Bei der intraoperativen Navigation finden hauptsächlich optische und elektromagnetische Ortungssysteme Anwendung. Besonders bei komplexen Eingriffen mit erheblichem Einsatz von Personal und Equipment bieten elektromagnetische Ortungssysteme Vorteile bei der Integration von Navigation in den klinischen Ablauf, da diese Systeme keinen direkten Sichtkontakt zwischen den Komponenten benötigen. Ferromagnetische Störsignale können die Anwendungsgenauigkeit beeinträchtigen. Wir haben in einem experimentellen OP Genauigkeitsmessungen bei elektromagnetischem tracking und Verwendung von verschiedenen Mikroskopmodellen durchgeführt und dabei signifikante Unterschiede bei dem total target error (TTE) festgestellt. Es wurde der TTE bei Titanschrauben an chirurgisch relevanten Strukturen der Frontobasis und Laterobasis gemessen. Die modernen „grossen“ Mikroskope führen zu schlechteren Ergebnissen. Für den Einsatz von elektromagnetischem Tracking bei mikroskopischen Schädelbasiseingriffen sind Verbesserung im Bereich Hardals auch Software nötig. Schlüsselworte: Navigation, Schädelbasis, tracking
Pharmacological and functional characterization of novel EP and DP receptor agonists: DP1 receptor mediates penile erection in multiple species.

INTRODUCTION Despite the widespread use of prostaglandin E(1) as an efficacious treatment for male erectile dysfunction for more than two decades, research on prostanoid function in penile physiology has been limited. AIM To characterize the pharmacological and physiological activity of novel subtype-selective EP and DP receptor agonists. METHODS Radioligand binding and second messenger assays were used to define receptor subtype specificity of the EP and DP agonists. Functional activity was further characterized using isolated human and rabbit penile cavernosal tissue in organ baths. In vivo activity was assessed in rabbits and rats by measuring changes in cavernous pressure after intracavernosal injection of receptor agonists. MAIN OUTCOME MEASURES Receptor binding and signal transduction, smooth muscle contractile activity, erectile function. RESULTS In organ bath preparations of human cavernosal tissue contracted with phenylephrine, EP2- and EP4-selective agonists exhibited variable potency in causing relaxation. One of the compounds caused mild contraction, and none of the compounds was as effective as PGE(1) (EC(50) = 0.23 microM). There was no consistent correlation between the pharmacological profile (receptor binding and second messenger assays) of the EP agonists and their effect on cavernosal tissue tone. In contrast, the DP1-selective agonist AS702224 (EC(50) =29 nM) was more effective in relaxing human cavernosal tissue than either PGE(1), PGD(2) (EC(50) = 58 nM), or the DP agonist BW245C (EC(50) =59 nM). In rabbit cavernosal tissue, PGE(1) and PGD(2) caused only contraction, while AS702224 and BW245C caused relaxation. Intracavernosal administration of AS702224 and BW245C also caused penile tumescence in rabbits and rats. For each compound, the erectile response improved with increasing dose and was significantly higher than vehicle alone. CONCLUSIONS These data suggest that AS702224 is a potent DP1-selective agonist that causes penile erection. The DP1 receptor mediates relaxation in human cavernosal tissue, and stimulates pro-erectile responses in rat and rabbit. Thus, rabbits and rats can be useful models for investigating the physiological function of DP1 receptors.
Regulation of Amphetamine-stimulated Dopamine Efflux by Protein Kinase C β*

Evidence suggests that protein kinase C (PKC) and intracellular calcium are important for amphetamine-stimulated outward transport of dopamine in rat striatum. In this study, we examined the effect of select PKC isoforms on amphetamine-stimulated dopamine efflux, focusing on Ca2+-dependent forms of PKC. Efflux of endogenous dopamine was measured in superfused rat striatal slices; dopamine was measured by high performance liquid chromatography. The non-selective classical PKC inhibitor Gö6976 inhibited amphetamine-stimulated dopamine efflux, whereas rottlerin, a specific inhibitor of PKCδ, had no effect. A highly specific PKCβ inhibitor, LY379196, blocked dopamine efflux that was stimulated by either amphetamine or the PKC activator, 12-O-tetradecanoylphorbol-13-acetate. None of the PKC inhibitors significantly altered [3H]dopamine uptake. PKCβI and PKCβII, but not PKCα or PKCγ, were co-immunoprecipitated from rat striatal membranes with the dopamine transporter (DAT). Conversely, antisera to PKCβI and PKCβII but not PKCα or PKCγ were able to co-immunoprecipitate DAT. Amphetamine-stimulated dopamine efflux was significantly enhanced in hDAT-HEK 293 cells transfected with PKCβII as compared with hDAT-HEK 293 cells alone, or hDAT-HEK 293 cells transfected with PKCα or PKCβI. These results suggest that classical PKCβII is physically associated with DAT and is important in maintaining the amphetamine-stimulated outward transport of dopamine in rat striatum.
Topologies Adaptatives dans un système NN/SOM

Resume: Dans cet article, nous proposons un modele combinant d’une part un reseau de neurones a couches de convolution permettant la classification, et d’autre part une carte auto-organisatrice adaptee a la classification de neurones permettant de normaliser le classifieur en adaptant sa topologie suivant des criteres de rejet. Ce modele permet d’ameliorer le nombre d’echantillons reconnus par un processus iteratif ou la topologie du classifieur est modifiee a chaque etape selon ses propres resultats. L’objectif est de recuperer les echantillons reconnus mais ne respectant pas les criteres de rejet a travers une adaptation de la topologie du classifieur dictee par une carte auto-organisatrice specifique. Mots cles: carte auto-organisatrice, reseau de neurones a convolution, reconnaissance de caracteres, topologies adaptatives.
Mechanisms of Resistance to Bacteriocins Targeting the Mannose Phosphotransferase System

ABSTRACT The membrane proteins IIC and IID of the mannose phosphotransferase system (Man-PTS) together form a membrane-located complex that serves as a receptor for several different bacteriocins, including the pediocin-like class IIa bacteriocins and the class IIc bacteriocin lactococcin A. Bacterial strains sensitive to class IIa bacteriocins readily give rise to resistant mutants upon bacteriocin exposure. In the present study, we have therefore investigated lactococcin A-resistant mutants of Lactococcus lactis as well as natural food isolates of Listeria monocytogenes with different susceptibilities to class IIa bacteriocins. We found two major mechanisms of resistance. The first involves downregulation of Man-PTS gene expression, which takes place both in spontaneous resistant mutants and in natural resistant isolates. The second involves normal expression of the Man-PTS system, but the underlying mechanism of resistance for these cells is unknown. In some cases, the resistant phenotype was linked to a shift in the metabolism; i.e., reduced growth on glucose due to reduction in Man-PTS expression was accompanied by enhanced growth on another sugar, such as galactose. The implications of these findings in terms of metabolic heterogeneity are discussed.
Second Skin: An Exploration of eTextile Stretch Circuits on the Body

Second Skin is a stretch electronic textile (eTextile) garment that adapts to the shape of the body. It is designed as both a provocative outer shell and a functioning undergarment, or foundation garment. Using elastic materials and building on techniques from cutting edge sportswear manufacturing, it facilitates wearable electronics which can recede from the users attention. We consider Second Skin as a platform that other researchers can use to add functionality of their own. In our exhibit, people can interact with a prototype version of Second Skin as well as with material samples to gain a better understanding of its look, feel and material capabilities.
Genetics of schizophrenia from a clinicial perspective

Abstract Schizophrenia (SZ) is a common disorder that runs in families. It has a relatively high heritability, i.e. inherited factors account for the major proportion of its etiology. The high heritability has motivated gene mapping studies that have improved in sophistication through the past two decades. Belying earlier expectations, it is now becoming increasingly clear that the cause of SZ does not reside in a single mutation, or even in a single gene. Rather, there are multiple DNA variants, not all of which have been identified. Additional risk may be conferred by interactions between individual DNA variants, as well as ‘gene-environment’ interactions. We review studies that have accounted for a fraction of the heritability. Their relevance to the practising clinician is discussed. We propose that continuing research in DNA variation, in conjunction with rapid ongoing advances in allied fields, will yield dividends from the perspective of diagnosis, treatment prediction through pharmacogenetics, and rational treatment through discoveries in pathogenesis.
Model of Consumer Decision Making: An Empirical Study at Credit Card Customer In Jakarta

There is an increasing development of credit card products within the banking industry. This rapid pace of development has sparked fierce competition in the race to acquire shares in this business market. The methods used for this research are description and explanatory survey. This paper tests the hypothesis that sales competency and brand image are associated with consumer decision making by using the method analysis of multiple regression or path analysis. Information was collected from 100 credit card customers at Airport Executive Lounge in Terminal 3 Jakarta to support this hypothesis. This suggests that sales competence and brand image should be rationalized to increase customer decision making in choosing a credit card, but sales competence seems to be more dominant. The contribution this research can make to bank sales competence is very important in order for customers to be able to select a credit card, aside from making a selection based on credit card brand image only, because credit card sales competence can give clear information to customers about credit card products.
NVMLearn: A simulation platform for non-volatile-memory-based deep learning hardware

Hardware implementation of deep machine learning using the convolutional neural network has been successfully demonstrated using array architecture with non-volatile storage elements such as floating-gate MOS transistor, resistive memory, phase change memory, etc. We present a new simulation platform, NVMLearn, to aid the design, verification, and system-level power and performance estimation for such architecture. Physical characteristics of memory devices are modeled using Verilog-A compact models, which can be easily simulated in SPICE to obtain the device programming, erasure, and read behavior. On the system level, NVMLearn simulates the training of the entire convolutional network based on any non-volatile memory device type.
Examining Stakeholder Participation in Social Stability Risk Assessment for Mega Projects Using Network Analysis

The paper examines stakeholder participation of social stability risk assessment for mega projects in China from a network perspective, with participatory decision-making in a political system discussed. From this analysis, we developed and tested hypotheses on stakeholder participation in social stability risk assessment. Using data obtained through content analysis, we established network on each compulsory procedure in social stability risk assessment to test the hypotheses. Additional impactful factors were discussed using singular value decomposition method in the study. We also provided practical implications and suggestions for policy and practice in the article.
Effect of substituted mercaptopurines on the rat litter in utero.

6-Amyl, 6-propyl, and 6-benzyl, 2-amino-6-benzyl and 6-(2'4' dinitrophenyl)-mercaptopurine (mp) were examined for the effect on the rat litter in utero. The toxicity of the LD50 for the mother rat varied from 300 to more than 500 mg/kg. Complete litter destruction with the compounds was possible on the 7th day ofgestation with doses tolerated by the mothers. The best ratios between LD50 to the mother and the lethal dose to the litter of 1 : 12 were obtained with 6-(2'4' dinitrophenyl) and of 1 : 10 with 2-amino-6-benzyl-mp. This was followed by 6-propyl and 6-benzyl-mp with a ratio of 1 : 5, followed by 6-amyl\x=req-\
The Distal Short Consensus Repeats 1 and 2 of the Membrane Cofactor Protein CD46 and Their Distance from the Cell Membrane Determine Productive Entry of Species B Adenovirus Serotype 35

ABSTRACT The human regulator of complement activation membrane cofactor protein (CD46) has recently been identified as an attachment receptor for most species B adenoviruses (Ads), including Ad type 3 (Ad3), Ad11, and Ad35, as well as species D Ad37. To characterize the interaction between Ad35 and CD46, hybrid receptors composed of different CD46 short consensus repeat (SCR) domains fused to immunoglobulin-like domains of CD4 and a set of 36 CD46 mutants containing semiconservative changes of single amino acids within SCR domains I and II were tested in binding and in Ad35-mediated luciferase transduction assays. In addition, anti-CD46 antibodies and soluble polypeptides constituting various CD46 domains were used in binding inhibition studies. Our data indicate that (i) CD46 SCR I or SCR II alone confers low but significant Ad35 binding; (ii) the presence of SCR I and II is required for optimal binding and transgene expression; (iii) transduction efficiencies equivalent to that of full-length CD46 are obtained if SCR I and II are at an appropriate distance from the cell membrane; (iv) ablation of the N-glycan attached to SCR I has no influence on receptor function, whereas ablation of the SCR II N-glycan results in about a two- to threefold reduction of binding and transgene expression; (v) most putative Ad35 binding residues are located on the same solvent-exposed face of the SCR I or SCR II domain, which are twisted by about 90°; and (vi) the putative Ad35 binding sites partly overlap with the measles virus binding surface.
Massive pleural effusion and marked increase of CA-125

The tumour associated CA-125 antigen is widely used in monitoring ovarian carcinoma. In women with a massive pleural effusion and ascites, markedly increased CA-125 levels may lead to an erroneous diagnosis of ovarian cancer. Very high levels of tumour markers may be present in patients with benign pleural effusion, ascites, and chronic liver disease. Raised levels of tumour markers in serum or pleural fluid, in the absence of positive cytology, should be interpreted with caution.
Relational Reinforcement Learning for Planning with Exogenous Effects

Probabilistic planners have improved recently to the point that they can solve difficult tasks with complex and expressive models. In contrast, learners cannot tackle yet the expressive models that planners do, which forces complex models to be mostly handcrafted. We propose a new learning approach that can learn relational probabilistic models with both action effects and exogenous effects. The proposed learning approach combines a multivalued variant of inductive logic programming for the generation of candidate models, with an optimization method to select the best set of planning operators to model a problem. We also show how to combine this learner with reinforcement learning algorithms to solve complete problems. Finally, experimental validation is provided that shows improvements over previous work in both simulation and a robotic task. The robotic task involves a dynamic scenario with several agents where a manipulator robot has to clear the tableware on a table. We show that the exogenous effects learned by our approach allowed the robot to clear the table in a more efficient way.
Pengaruh Kegiatan Wisata terhadap Perubahan Penggunaan Lahan di Kecamatan Tawangmangu, Kabupaten Karanganyar

Karanganyar is one of regency in Central Java province which it ’ s potential tourist destinations are quite diverse. Nature destinations is one of the tourism assets which commonly found in Karanganyar, facts shown that the existing landscape conditions vary widely from highland terrain to the landscape of coastal lowland forest. Tourism se c tor contributes in a significance economic scale towards local incomes of Karanganyar Regency. One district which became the center of tourism activities development is Tawangmangu. Tawangmangu district has an integrated tourism destination named Kawasan Wisata Tawangmangu, which consist of several tourism place option like Grojogan Sewu Waterfall , Sapta Tirta, Campgrounds Sekipan, and Taman Ria Balekambang. Because it is the main area of tourism destination in Karanganyar, adequate infrastructure is available and regularly upgraded in the annual basis , because those improvements is needed to support massive tourism activities which might occurred . With the tourism activities development such as newly constructed infrastructure or addition of a few supporting facilities will certainly give effect to the land use transformation of those aforementioned surroundings . This study aimed to analyze the effects of tourism activities towards land use transformation and analyze the causes of changes regarding land use in the Tawangmangu District . In the process of answering these objectives, this study used descriptive qualitative approach. Research on the effects of tourism activities is based on four main analysis, which is tourism characteristic activities , land use transformation, effects of tourism activities towards land use transformation, and the causes of effect of land use transformation. From those four baseline analysis, result shows that tourism activities which has been occurred so far only affects certain areas of Kalisoro, Tawangmangu, and Blumbang. As for the case of land use transformation, in other villages they are not affected by the exi s tence of tourism activities. Besides tourism , land use transformation in the Tawangmangu District also caused by environmental quality, land values, accessibility, also availability of basic decent facilities and infrastructure.
Quality, patient safety and the implementation of best evidence: provinces in the country of knowledge translation.

ong a world model, Canada’s healthcare system faces many challenges to ensure its sustainability. Research evidence, generated at an exponential rate, is not readily available to clinicians. When available, it is often infrequently or incorrectly applied in clinical practice (Davenport and Glaser 2002; Covell et al. 1985; Ramos et al. 2003). This failure of rapid evidence adoption leads to sizable gaps between high-quality evidence and practice, significant practice variation, and in many cases lapses in patient safety (Chassin and Galvin 1998; Buchan 2004). This gap is deleterious to the health of Canadians, increasing morbidity and mortality and generating serious and detrimental cost implication (Olson et al. 2001; Villar et al. 2001; Boissel et al. 2004; Tsuyuki et al. 2005). This finding, that providing evidence from research or from quality assessments is a necessary but not sufficient condition for the provision of care, has created the field of knowledge translation, the scientific study of the methods for closing the knowledge-to-practice gap and the analysis of barriers and facilitators inherent in the process. As defined by the Cambridge Conference, KT is “the iterative, timely and effective process of integrating best evidence into the routine practices of patients, practitioners, health care teams and systems, in order to effect optimal health care outcomes and to maximize the potential of the health care system” (11th Cambridge Conference 2003). For our purposes, KT is intended to subsume issues of patient safety, continuing education and guideline implementation, in order to achieve, in the words of CIHR, the “optimization of health care and health care systems” (CIHR 2005); they are, in this view, “provinces in the country of KT. ” Patient safety and quality improvement provide compelling examples of both process (how to improve care) and content innovation (what to do to improve it). The significant gap in care and the quest for patient safety and in the Canadian context call for a programmatic approach to the testing and implementation of evidence-based health knowledge translation strategies.
Porin-Mediated Antibiotic Resistance in Neisseria gonorrhoeae: Ion, Solute, and Antibiotic Permeation through PIB Proteins with penB Mutations

ABSTRACT Neisseria gonorrhoeae has two porins, PIA and PIB, whose genes (porA and porB, respectively) are alleles of a single por locus. We recently demonstrated that penB mutations at positions 120 and 121 in PIB, which are presumed to reside in loop 3 that forms the pore constriction zone, confer intermediate-level resistance to penicillin and tetracycline (M. Olesky, M. Hobbs, and R. A. Nicholas, Antimicrob. Agents Chemother. 46:2811-2820, 2002). In the present study, we investigated the electrophysiological properties as well as solute and antibiotic permeation rates of recombinant PIB proteins containing penB mutations (G120K, G120D/A121D, G120P/A121P, and G120R/A121H). In planar lipid bilayers, the predominant conducting state of each porin variant was 30 to 40% of the wild type, even though the anion selectivity and maximum channel conductance of each PIB variant was similar to that of the wild type. Liposome-swelling experiments revealed no significant differences in the permeation of sugars or β-lactam antibiotics through the wild type or PIB variants. Although these results are seemingly contradictory with the ability of these variants to increase antibiotic resistance, they are consistent with MIC data showing that these porin mutations confer resistance only in strains containing an mtrR mutation, which increases expression of the MtrC-MtrD-MtrE efflux pump. Moreover, both the mtrR and penB mutations were required to decrease in vivo permeation rates below those observed in the parental strain containing either mtrR or porin mutations alone. Thus, these data demonstrate a novel mechanism of porin-mediated resistance in which mutations in PIB have no affect on antibiotic permeation alone but instead act synergistically with the MtrC-MtrD-MtrE efflux pump in the development of antibiotic resistance in gonococci.
The Mediating Role of Environmental Attitude on the Impact of Environmental Concern on Green Product Purchasing Intention

Environmental pollution, increasing damages in the nature and deformation of ecosytem have started to worry consumers and the environemental concern has formed in time. Consumers who have environmental concern and wish to lend a healthy and clean environment to next generations, then started to consider the damages of their products to the nature in a higher degree. Thus, consumers with environmental concern have placed more importance to green products, which do not pollute the nature, use natural resources less, enable recycling, but are environmental friendly. The aim of this study is to investigate the impact of environmental concern on green product purchase intention, and to also investigate the mediating role of environmental attitude on the mentioned impact. Research data were gathered from 410 individuals residing in İzmir city using the face-to-face questionnaire method. Then, the data were tested with Crobach Alpha Method, Test of Normality, Exploratory Factor Analysis, Confirmatory Factor Analysis, Structural Equation Modeling and Sobel test. Based on research findings, it is observed that environmental attitude has a mediating role on the impact of environmental concern on green product purchasing intention. It is also determined that, environmental concern has a meaningful impact on environmental attitude and green product purchasing intention, and environmental attitude has a meaningful impact on green product purchasing intention.