Miracle-dz/UniFAR-FTUs huggingface dataset:
Interactive Optimization of Generative Image Modelling using Sequential Subspace Search and Content‐based Guidance

Generative image modeling techniques such as GAN demonstrate highly convincing image generation result. However, user interaction is often necessary to obtain desired results. Existing attempts add interactivity but require either tailored architectures or extra data. We present a human‐in‐the‐optimization method that allows users to directly explore and search the latent vector space of generative image modelling. Our system provides multiple candidates by sampling the latent vector space, and the user selects the best blending weights within the subspace using multiple sliders. In addition, the user can express their intention through image editing tools. The system samples latent vectors based on inputs and presents new candidates to the user iteratively. An advantage of our formulation is that one can apply our method to arbitrary pre‐trained model without developing specialized architecture or data. We demonstrate our method with various generative image modelling applications, and show superior performance in a comparative user study with prior art iGAN [ZKSE16].
Assigning tasks to agents under time conflicts: a parameterized complexity approach

We consider the problem of assigning tasks to agents under time conflicts, with applications also to frequency allocations in point-to-point wireless networks. In particular, we are given a set $V$ of $n$ agents, a set $E$ of $m$ tasks, and $k$ different time slots. Each task can be carried out in one of the $k$ predefined time slots, and can be represented by the subset $e\subseteq E$ of the involved agents. Since each agent cannot participate to more than one task simultaneously, we must find an allocation that assigns non-overlapping tasks to each time slot. Being the number of slots limited by $k$, in general it is not possible to executed all the possible tasks, and our aim is to determine a solution maximizing the overall social welfare, that is the number of executed tasks. We focus on the restriction of this problem in which the number of time slots is fixed to be $k=2$, and each task is performed by exactly two agents, that is $|e|=2$. In fact, even under this assumptions, the problem is still challenging, as it remains computationally difficult. We provide parameterized complexity results with respect to several reasonable parameters, showing for the different cases that the problem is fixed-parameter tractable or it is paraNP-hard.
A note on suprema of infinitely divisible processes

In this note we extend the result concerning suprema of infinitely divisible processes established by M. Talagrand to the processes for which we relax technical requirement called the H(C0, δ) condition. 1 Overview of the result It is a long-term program to investigate properties of general Lévy-type processes. It is unexpectedly hard to provide some unified approach to this matter and what is usually done in practice is to explore the behaviour of specific examples separately. Initial attempt to deal with this task was done by M. Talagrand in 1993 [7], where the regularity of infinitely divisible processes was proved under additional technical assumption on the Lévy measure. It was conjectured that the result holds without it, however little progress on this problem has been done since then. The main difficulty was related to the fact that the Bernoulli Conjecture (see [1]) was still open then. Our goal is to prove that the Talagrand’s conjecture holds true. The essential technical tool in the study of infinitely divisible processes is its’ series representation due to J. Rosiński [3]. Consider a σ-finite measure space (Ω, ν) and a Poisson point process of intensity ν on Ω (see e.g. [2] for the introduction to the subject of such processes). Recall it is a random subset Π of Ω such that for any measurable subset A of finite intensity measure a cardinality of Ω ∩ Π denoted by |Ω ∩ Π| is a Poisson random variable of expectation ν(A) < ∞ and for disjoint measurable subsets A1, . , Ak random variables (|Ai ∩Π|)16i6k are independent. We denote elements of Π by (Zi)i>1. By (εi)i≥1 we denote a sequence of random signs (Bernoulli sequence) i.e. P(εi = ±1) = 1/2 independent of (Zi)i>1. It is a delicate matter whether the construction of elements of the random set is well-defined. However, we just refer to [3] for details since what is crucial for our work is the existence of the series representation of infinitely divisible processes. For this reason and the fact that we want to work with such processes in full generality we use the following definition. It is different from a classical terminology used in this area as might be found for example in [4]. Definition 1 An infinitely divisible (symmetric, without Gaussian component) process is a collection (Xt)t∈T where T is a set of functions on Ω satisfying ∫ Ω t 2 ∧ 1dν < ∞ for t ∈ T and where Xt =
Lingual lymph nodes: Anatomy, clinical considerations, and oncological significance

Lingual lymph nodes are an inconstant group of in-transit nodes, which are located on the route of lymph drainage from the tongue mucosa to the regional nodes in neck levels I and II. There is growing academic data on the metastatic spread of oral cancer, particularly regarding the spreading of oral tongue squamous cell carcinoma to lingual nodes. These nodes are not currently included in diagnostic and treatment protocols for oral tongue cancer. Combined information on surgical anatomy, clinical observations, means of detection, and prognostic value is presented. Anatomically obtained incidence of lingual nodes ranges from 8.6% to 30.2%. Incidence of lingual lymph node metastasis ranges from 1.3% to 17.1%. It is clear that lymph nodes that bear intervening tissues from the floor of the mouth should be removed to improve loco-regional control. Extended resection volume, which is required for the surgical treatment of lingual node metastasis, cannot be implied to every tongue cancer patient. As these lesions significantly influence prognosis, special efforts of their detection must be made. Reasonably, every tongue cancer patient must be investigated for the existence of lingual lymph node metastasis. Lymphographic tracing methods, which are currently implied for sentinel lymph node biopsies, may improve the detection of lingual lymph nodes.
Genetic Theory of the Rh Blood Types.∗

Summary Three varieties of anti-Rh agglutinins have been encountered, designated as anti-Rh (standard), anti-Rh1, and anti-Rh2, and agglutinating, respectively, approximately 85%, 70%, and 35% of bloods from white individuals in New York City. Human sera containing agglutinins anti-Rh and anti-Rh1 together are designated anti-Rh' sera containing the two agglutinins anti-Rh and anti-Rh2 are designated anti-Rh”. By means of the 3 sorts of Rh agglutinins, 5 varieties of Rh agglutinogens are demonstrable, designated as Rh1, Rh2, Rh, Rh′, and Rh”. These in combination give rise to 8 Rh blood types (including the Rh-negative type), of which all but one, the rarest, have actually been encountered. A theory to explain the heredity of the Rh blood types is proposed in which the existence of 6 allelic genes is postulated. Evidence in support of the theory is presented and some of the implications of the theory are mentioned.
Traumatic thoracolumbar fracture–dislocation in an infant: surgical management using posterior thoracolumbar instrumentation

Abstract Spinal fracture–dislocation in the infantile population is a rare phenomenon, and its surgical management remains poorly discussed in the literature. This article reports a case of traumatic fracture–dislocation in an infant by outlining the surgical management and extensively reviewing the literature. An 8-month-old girl was involved in a motor vehicle accident and was ejected from the car through the windshield. Radiological imaging demonstrated a complete spinal cord injury at the level of T10 and a three-column fracture of T12-L1, with an evidence of kyphosis measuring 47° at the fracture site. Posterior thoracolumbar instrumentation, using the posterior cervical fixation set, was successfully performed. In experienced neurosurgical centers, posterior thoracolumbar instrumentation can be safely performed in infants with traumatic thoracolumbar fracture–dislocation. This allows for the correction of the kyphotic deformity, facilitation of the rehabilitation course and improvement in the health-related quality of life.
Inhibition of lncRNA TMPO-AS1 suppresses proliferation, migration and invasion of colorectal cancer cells by targeting miR-143-3p

Long non-coding RNAs (lncRNAs) are widely studied in cancer pathogenesis. Accumulating evidence has demonstrated that lncRNAs are involved in the cellular progression of colorectal cancer (CRC). However, the regulatory mechanism of lncRNA TMPO-antisense (AS)1 in CRC has not been fully elucidated. The present study aimed to elucidate the role and regulatory mechanisms of lncRNA TMPO-AS1 in CRC. In the present study, the expression levels of TMPO-AS1 and microRNA-143-3p (miR-143-3p) were detected using reverse transcription-quantitative PCR assay. The relative protein expression levels were measured via western blot analysis. MTT and Transwell assays were used to determine cell proliferation, migration and invasion, while a luciferase reporter assay was performed to assess the relationship between TMPO-AS1 and miR-143-3p. In addition, a tumor animal model was used to investigate the effect of TMPO-AS1 on tumor growth in CRC in vivo. TMPO-AS1 expression was increased and miR-143-3p expression was decreased in CRC cells. TMPO-AS1 knockdown and miR-143-3p overexpression significantly inhibited cell proliferation, migration and invasion of CRC cells. Luciferase reporter assay results demonstrated that miR-143-3p was a direct target of TMPO-AS1. Inhibition of miR-143-3p could alleviate the suppressive effects of TMPO-AS1 deletion on cell proliferation, migration and invasion of CRC cells. Furthermore, TMPO-AS1 deletion could inhibit tumor growth in CRC in vivo. It was concluded that TMPO-AS1 regulated cell proliferation, migration and invasion of CRC cells by targeting miR-143-3p. These findings provided a new regulatory network and therapeutic target for the treatment of CRC.
Density of Musashi-1-positive stem cells in the stomach of patients with irritable bowel syndrome

Irritable bowel syndrome (IBS) affects ~12% of the global population. Although the etiology of IBS is not completely understood, several factors are known to serve a pivotal role in its pathophysiology, including genetic factors, diet, the intestinal microbiota, gastrointestinal endocrine cells and low-grade inflammation. Musashi-1 is expressed by stem cells and their early progeny, and is used as a stem cell marker. The low density of intestinal endocrine cells in patients with IBS is thought to be caused by decreased numbers of intestinal stem cells and their differentiation into enteroendocrine cells. The present study employed Musashi-1 as a marker to detect stem cells in the stomach of 54 patients with IBS and 51 healthy subjects. The patients and controls underwent standard gastroscopy, and biopsy samples were taken from the corpus and antrum. Immunohistochemical staining of gastrin, somatostatin and Mushasi-1 was carried out and semi-quantified by computerized image analysis. The density (number of positive cells/mm2 epithelium) of gastrin-positive cells in the controls and patients with IBS were 337.9±560 and 531.0±908 (median ± range; P<0.0001), respectively. For somatostatin-positive cells, the density reached 364.4±526.0 in the healthy controls and 150.7±514.0 in patients with IBS (P<0.0001). The density of Musashi-1-positive cells was defined as the number of cells per gastric or pyloric gland neck. In the corpus, Musashi-1-positive cells density reached 3.0±7.0 in the corpus of the healthy controls and 3.8±7.7 in the patients with IBS. Moreover, the corresponding values in the antrum were 6.0±6.0 and 6.0±6.0, respectively. The Musashi-1-positive cell density did not differ significantly between the controls and patients with IBS in the corpus or antrum (P=0.4 and 0.3, respectively). These findings indicated that changes in the stomach endocrine cells observed in patients with IBS may not be explained by an abnormality in stem cells like those found in the small and large intestines of these patients.
A Novel RFXANK Mutation in a Chinese Child With MHC II Deficiency: Case Report and Literature Review

Abstract Major histocompatibility complex (MHC) II deficiency is a rare primary immunodeficiency disorder that is characterized by the deficiency of MHC class II molecules. The disease is caused by transcription factor mutations including class II transactivator (CIITA), regulatory factor X-5 (RFX5), RFX-associated protein (RFXAP), and RFXAP-containing ankyrin repeat (RFXANK), respectively. Mutations in the RFXANK gene account for >70% of all known patients worldwide. Herein, we reported a 10-month-old boy with MHC II deficiency caused by a novel mutation in the RFXANK gene (c.337 + 1G>C). The boy was admitted to the hospital due to pneumonia and diarrhea at 4 months of age. Genetic analysis revealed a novel homozygous mutation in the RFXANK gene, which derived from the c.337 + 1G>C heterozygous mutations in the RFXANK gene of his parents. The boy died 3 months after diagnosis. More than 200 cases have been reported, and a review of the literature revealed different mutation rates of 4 transcription factors in different countries or regions. This is the first case report of MHC II deficiency from East Asia. We also describe all gene mutations that cause MHC II deficiency and the epidemiology of MHC II deficiency with gene mutations in this paper.
“Looking for Deviations”: Nurses’ Observations of Older Patients With COPD in Home Nursing Care

Nurses working in home care play a significant role in observing and identifying changes in the health status of patient with chronic obstructive pulmonary disease (COPD). The aim of this study was to explore and describe nurses’ observations of older patients with COPD when providing home nursing care. In this qualitative explorative study, data were collected through observations of 17 home care visits using the think-aloud technique, followed up with individual interviews with the nurses. Qualitative content analysis was used to analyze the data. The findings showed that the nurses’ observations (focus, methods, and interpretation) were characterized by their search for deviations from what they judged to be the patient’s habitual state. The nurses did not use any tool or guidelines, nor did they follow a standard procedure. Instead, when observing and interpreting, they performed a complex process guided by their experience and knowledge of the patient, and the patient’s individual and contextual circumstances. This knowledge contributes to warranted reflection on nurses’ practice in this context to secure COPD patients’ safety and quality of life.
Association between pre-chemotherapy serum levels of vitamin D and clinicopathologic findings in gastric cancer

Background: To examine the serum levels of vitamin D in newly diagnosed gastric cancer (GC) patients compared with normal subjects and any possible association with prognostic variables. Methods: One-hundred subjects (50 GC and 50 controls) were enrolled and serum vitamin D levels were assessed using ELISA. Based on two definitions, vitamin D was classified as a sufficient level (≥30 ng/dL) and optimal level (25-80 ng/dL). The χ2and unpaired t-test was used for data analysis with a significance level of 0.05. Results: The mean serum levels of vitamin D in patients and controls were 26.86 (±14.6) and 31.72 (±13.4), respectively (P=0.09). The prevalence of vitamin D insufficiency and deficiency was higher in GC cases than controls (P=0.045 if sufficient level ≥30 and P=0.065 if sufficient level ≥25). According to histological grade analysis, grade 3 patients (poorly differentiated) were found with significantly lower vitamin D concentrations in serum than grade 1 and 2 subjects (22.25 vs 33.29 ng/dL, P=0.021). No significant differences were observed between the two groups in pathological tumor-node-metastasis (pTNM) stages, distant metastasis, and location of the tumor. Conclusion: Higher prevalence of vitamin D insufficiency and deficiency in GC patients may reflect its role in malignancy; however, further studies are needed to confirm this relationship and any possible benefits to the patients.
Machine Learning Model for Risk Prediction of Community-Acquired Acute Kidney Injury Hospitalization From Electronic Health Records: Development and Validation Study

Background Community-acquired acute kidney injury (CA-AKI)-associated hospitalizations impose significant health care needs and contribute to in-hospital mortality. However, most risk prediction models developed to date have focused on AKI in a specific group of patients during hospitalization, and there is limited knowledge on the baseline risk in the general population for preventing CA-AKI-associated hospitalization. Objective To gain further insight into risk exploration, the aim of this study was to develop, validate, and establish a scoring system to facilitate health professionals in enabling early recognition and intervention of CA-AKI to prevent permanent kidney damage using different machine-learning techniques. Methods A nested case-control study design was employed using electronic health records derived from a group of Chang Gung Memorial Hospitals in Taiwan from 2010 to 2017 to identify 234,867 adults with at least two measures of serum creatinine at hospital admission. Patients were classified into a derivation cohort (2010-2016) and a temporal validation cohort (2017). Patients with the first episode of CA-AKI at hospital admission were classified into the case group and those without CA-AKI were classified in the control group. A total of 47 potential candidate variables, including age, gender, prior use of nephrotoxic medications, Charlson comorbid conditions, commonly measured laboratory results, and recent use of health services, were tested to develop a CA-AKI hospitalization risk model. Permutation-based selection with both the extreme gradient boost (XGBoost) and least absolute shrinkage and selection operator (LASSO) algorithms was performed to determine the top 10 important features for scoring function development. Results The discriminative ability of the risk model was assessed by the area under the receiver operating characteristic curve (AUC), and the predictive CA-AKI risk model derived by the logistic regression algorithm achieved an AUC of 0.767 (95% CI 0.764-0.770) on derivation and 0.761 on validation for any stage of AKI, with positive and negative predictive values of 19.2% and 96.1%, respectively. The risk model for prediction of CA-AKI stages 2 and 3 had an AUC value of 0.818 for the validation cohort with positive and negative predictive values of 13.3% and 98.4%, respectively. These metrics were evaluated at a cut-off value of 7.993, which was determined as the threshold to discriminate the risk of AKI. Conclusions A machine learning–generated risk score model can identify patients at risk of developing CA-AKI-related hospitalization through a routine care data-driven approach. The validated multivariate risk assessment tool could help clinicians to stratify patients in primary care, and to provide monitoring and early intervention for preventing AKI while improving the quality of AKI care in the general population.
Prevalence of Diabetes and Hypertension and Their Associated Risks for Poor Outcomes in Covid-19 Patients

Abstract Coronavirus disease 2019 (Covid-19) has affected millions of people and may disproportionately affect those with hypertension and diabetes. Because of inadequate methods in published systematic reviews, the prevalence of diabetes and hypertension and associated risks of poor outcomes in Covid-19 patients are unknown. We searched databases from December 1, 2019, to April 6, 2020, and selected observational peer-reviewed studies in English of patients with Covid-19. Independent reviewers extracted data on study participants, interventions, and outcomes and assessed risk of bias, and the certainty of evidence. We included 65 (15 794 participants) observational studies at moderate to high risk of bias. Overall prevalence of diabetes and hypertension was 12% (95% confidence interval [CI], 10-15; n = 12 870; I2: 89%), and 17% (95% CI, 13-22; n = 12 709; I2: 95%), respectively. In severe Covid-19, the prevalence of diabetes and hypertension were 18% (95% CI, 16-20; n = 1099; I2: 0%) and 32% (95% CI, 16-54; n = 1078; I2: 63%), respectively. Unadjusted relative risk for intensive care unit admission and mortality were 1.96 (95% CI, 1.19-3.22; n = 8890; I2: 80%; P = .008) and 2.78 (95% CI, 1.39-5.58; n = 2058; I2: 75%; P = .0004) for diabetics; and 2.95 (95% CI, 2.18-3.99; n = 1737; I2: 0%; P < .001) and 2.39 (95% CI, 1.54-3.73; n = 3107; I2: 66%; P < .001) for hypertensives. Neither diabetes (1.50; 95% CI, 0.90-2.50; n = 1991; I2: 74%; P = .119) nor hypertension (1.48; 95% CI, 0.99-2.23; n = 2023; I2: 69%; P = .058) was associated with severe Covid-19. In conclusion, the risk of intensive care unit admission and mortality for patients with diabetes or hypertension who developed Covid-19 is increased compared with those without these comorbidities. PROSPERO registration number CRD42020176582.
Phosphorylation of STAT3 and ERBB2 mediates hypoxia-induced VEGF release in ARPE-19 cells

Neovascularization in the retina can cause loss of vision. Vascular endothelial growth factor (VEGF) serves an important role in the pathogenesis of retinal vascular diseases. Hypoxia is a notable cause of VEGF release and both STAT3 and ERBB2 are known to be associated with VEGF. In addition, STAT3 and ERBB2 interact with each other. In the present study, it was hypothesized that signal transducer and activator of transcription 3 (STAT3) and erbB-2 receptor tyrosine kinase 2 (ERBB2) may be involved in the regulation of hypoxia-induced VEGF in the retina. Cells of the retinal pigment epithelium (RPE) are an important source of VEGF. Therefore, the RPE-derived human cell line ARPE-19 was exposed to hypoxia. Hypoxia-induced phosphorylation of STAT3 and ERBB2 in ARPE-19 cells was decreased by AG490, an inhibitor of Janus kinase 2, as were hypoxia-induced VEGF release and tube formation in human umbilical vein endothelial cells. Thus, phosphorylation of ERBB2 and STAT3 regulates hypoxia-induced VEGF release in ARPE-19 cells. The results of the present study suggested that inhibition of ERBB2 and STAT3-mediated pathways under hypoxia may represent a new strategy for treating retinal vascular disease.