Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigating noncoding RNA biogenesis and function during mitosis

Mitosis is one of the most dramatic and complex processes in the life of a cell. Although first observed over 100 years ago, there are still many gaps in our understanding of this crucial process. Years of research into the mechanisms of cell division have uncovered many of the protein players required for the faithful execution of this essential process. However, very little is known about the roles of RNAs during mitosis. In my thesis work, I established several biological functions and regulatory modes employed by RNAs and the RNA biogenesis machinery that are essential for cell division. Using a variety of techniques, I showed that RNA biogenesis during mitosis is an essential step in the assembly of the mitotic spindle and mitotic chromatin. I also provided evidence that RNAs are required for microtubule generation, microtubule organization, and chromatin assembly. In addition, I developed automated image analysis tools to systematically assess mitotic spindle morphology for Xenopus egg extract spindle assembly reactions, a very challenging image analysis application. My work suggests that RNAs should be included as a broad class of regulatory molecules that are essential for the execution of eukaryotic cell division.
Ecological niches and present and historical geographic distributions of species: a 15-year review of frameworks, results, pitfalls, and promises

Abstract. We present an overview of the emerging field of species-level distributional ecology, particularly as it relates to phylogeographic studies of birds in Eurasia. This field centers around distributional inferences and predictions deriving from the use of ecological niche modeling. We provide a brief historical review, and then proceed to outline a number of crucial methodological considerations, if models are to have biological meaning and reality. We then proceed to provide a worked example, as well as some thinking about directions in which the field should be moving in terms of questions and approaches.
The Selection Problem for Constitutive Panpsychism

ABSTRACT Constitutive panpsychism is the doctrine that macro-level consciousness—that is, consciousness of the sort possessed by certain composite things such as humans—is built out of irreducibly mental (or proto-mental) features had by some or all of the basic physical constituents of reality. On constitutive panpsychism, changes in macro-level consciousness amount to changes in either the way that micro-conscious entities ‘bond’ or the way that micro-conscious qualities ‘blend’ (or both). I pose the ‘Selection Problem’ for constitutive panpsychism—the problem of explaining how high-level functional states of the brain ‘select’ micro-conscious qualities for bonding or blending. I argue that there are no empirically plausible solutions to this problem.
LDO Optimization with Evolutionary Neural Network

In this paper, a low voltage low dropout (LDO) regulator is designed and simulated in 0. 18µm CMOS technology, which converts an input voltage of 1.4V into a stable regulated output voltage of 1.2 V using H-Spice circuit simulator. The proposed LDO structure is based on Output Voltage Spike Reduction (OVSR) circuits and capacitance compensation circuits to enable a fast-transient response with ultra-low power dissipation and to make the LDO stable for a wide range of output load currents (0–50 mA). Here, the Artificial Neural network (ANN) algorithm is demonstrated for solving the problem of the device sizing and optimization. This approach for designing handles non-linear effects of sub-micron devices very effectively. The Simulation results verify that the transient times are less than 2.8 µs and the maximum undershoot and overshoot are 20 mV while consuming only 26 µA quiescent current. The proposed LDO is stable with an on-chip capacitor at the output node within the wide range of 1-100 PF.
Caractérisation de biomarqueurs cellulaires pour étudier la plasticité mammaire au cours de la lactation chez la vache laitière

La recherche sur la fonction de lactation est indispensable pour la filiere laitiere. La glande mammaire est un organe compose de cellules epitheliales, de cellules myoepitheliales, de fibroblastes, d’adipocytes et de cellules endotheliales. L’identification et l’evolution en dynamique des populations cellulaires dans la glande mammaire bovine au cours la lactation reste encore a ce jour meconnues. Les objectifs de cette these ont ete 1) l’obtention d’un panel des biomarqueurs pour identifier les differentes cellules dans la glande mammaire bovine et 2) le suivi de leur evolution au cours d’un cycle de lactation. Les biomarqueurs de surface (CD49f, EpCAM, CD24 et CD10) ont permis de phenotyper deux lignees mammaires bovines. Nous avons egalement utilise ces biomarqueurs pour phenotyper les cellules dans la glande mammaire bovine au cours d’un cycle de lactation.Dans cet objectif, des biopsies ont ete prelevees sur 5 vaches laitieres primipares a quatre etapes durant la lactation. Apres la digestion des biopsies, les cellules obtenues ont ete marquees et phenotypees par cytometrie en flux. L’analyse des resultats montre des correlations positives entre les populations cellulaires CD49f+ et CD49f+/CD24- avec la production laitiere. Nous avons mis en evidence une population cellulaire CD49f-/EpCAM- qui augmente au cours de la lactation. Ces resultats suggerent qu’a partir de l’utilisation de biomarqueurs il est possible d’identifier et phenotyper l’evolution de differentes cellules pendant la lactation dans la glande mammaire bovine.
Dialogic Communication and Thought Leadership: Twitter Use by Public Relations Agencies in the United States

Abstract This study examined how the 117 Twitter profiles maintained by U.S. headquartered agencies appearing in the 2017 Global Top 250 PR Agencies list from the Holmes Report are using this platform to communicate with their publics. Guided by the dialogic communication theory, a content analysis of 1,120 tweets (from the 112 agencies identified as having public active accounts) published between January and October 2017 were analyzed to better understand the content strategies implemented by these agencies as well as the relationship between levels of public engagement and the implementation of dialogic principles. Additionally, this study placed a special emphasis on thought leadership and the means being employed by agencies to introduce and promote their ideas. The study’s results suggest that while media vividness increases the public’s levels of engagement, interactivity has an inverse effect. At the same time, the findings indicate that agencies are not fully employing the dialogic capacity of Twitter. From a strategic point of view, this study provides significant implications for social media communication practices by public relations agencies.
Passion Project Journaling in the EFL Classroom

Judith Kambara Reference Data: Kambara, J. (2020). Passion project journaling in the EFL classroom. In P. Clements, A. Krause, & R. Gentry (Eds.), Teacher efficacy, learner agency. Tokyo: JALT. https://doi.org/10.37546/JALTPCP2019-45 Journaling activities in EFL classrooms, often based on prescribed journal prompts, are designed to elicit targeted grammar and vocabulary; however, prescribed prompts can be problematic because they lack a basis in reality and limit language structures available for use. After observing lackluster results with student journals based on prescribed topics, I introduced what I have termed passion project journaling in my 1st-year university English classes for general listening and speaking. Students were asked to journal extensively about topics in which they had a deep interest for the second of two 8-week terms in a semester-long course. Results showed marked increases in the average number of words per journal entry, range of language structures used, and topic engagement. Based on these results, I propose utilizing passion project journaling to increase students’ sense of self-efficacy and to grant learners the agency to acquire new vocabulary and language structures in meaningful contexts. 英語学習コースにおけるジャーナル活動は，通常、教員が決めたジャーナル・トピックに基づき，学習目標である文法や語彙を引き出すように設計されている。 しかし，このようなジャーナル活動は，現実性を欠き，使用される言語構造も制限してしまう問題がある。 筆者は，精彩を欠いたジャーナル活動を鑑み，筆者が担当している大学1年次のリスニング・スピーキングクラスに『パッション・プロジェクト・ジャーナリング』を導入した。 これは，学生各々が強く興味をもつトピックで，学期の後半8週間，各自のジャーナルをまとめていく活動である。 その結果，１ジャーナル当たりの使用語数，言語構造の幅が増加し，トピックについて積極的に関与する姿勢を示すように改善された。 筆者は，『パッション・プロジェクト・ジャーナリング』を，学生達の目標達成意欲向上や、有意義な文脈で新しい語彙や文の構造を学ぶ主体的学習者とするために活用することを提唱する。
A Green Demand-Responsive Airport Shuttle Service Problem with Time-Varying Speeds

This study proposes a multiobjective mixed integer linear programming (MOMILP) model for a demand-responsive airport shuttle service. The approach aims to assign a set of alternative fuel vehicles (AFVs) located at different depots to visit each demand point within the specified time and transport all of them to the airport. The proposed model effectively captures the interactions between path selection and environmental protection. Moreover, users with flexible pick-up time windows, the time-varying speed of vehicles on the road network, and the limited fuel for the route duration are also fully considered in this model. The work aims at simultaneously minimizing the operating cost, vehicle fuel consumption, and CO2 emissions. Since this task is an NP-hard problem, a heuristic-based nondominated sorting genetic algorithm (NSGA-II) is also presented to find Pareto optimal solutions in a reasonable amount of time. Finally, a real-world example is provided to illustrate the proposed methodology. The results demonstrate that the model not only selects an optimal depot for each AFV but also determines its route and timetable plan. A sensitivity analysis is also given to assess the effect of early/late arrival penalty weights and the number of AFVs on the model performance, and the difference in quality between the proposed and traditional models is compared.
Mandibular wear in Camponotus chromaoides workers (Hymenoptera: Formicidae).

Camponotus colonies have a worker subcaste, consisting of major and minor workers. This designation is based on the width and height of the head (cephalic index, CI). Performance of tasks by workers results in wear of the mandibular teeth. A sample of workers was taken from a laboratory colony of Camponotus chromaoides. The CI was calculated to determine the major (CI 106.9) and minor (CI 83.6) workers. The objective of the study was to document the characteristics and extent of mandibular wear, and to divide the wear into distinct categories. Grade 1: little or no wear, Grades 3 and 5: moderate wear of the teeth, and Grade 7: absence of mandibular teeth. The absence of incisor and molar teeth may benefit rather than diminish foraging tasks of workers.
Community structure extraction in directed network using triads

Community detection in directed networks appears as one of the most relevant topics in the field of network analysis. One of the common themes in its formalizations is information flow clustering in a network. Such clusters can be extracted by using triads, expected to play an important role in the detection of that type of communities since communities could be centered round core nodes called kernels. Triads in directed graphs are directed sub-graphs of three nodes involving at least two links between them. To identify communities in directed networks, this paper proposes an in-seed-centric scheme based on directed triads. We also propose a new metric of the communities' quality based on the triad density of communities. To validate our approach, an experiment was conducted on some networks showing it has better performance on triad-based density over some state-of-the-art methods.
Climate-change impacts and fisheries management challenges in the North Atlantic Ocean

Climate-induced changes in the world’s oceans will have implications for fisheries productivity and management. Using a model ensemble from the Fisheries and Marine Ecosystem Model Intercomparison Project (Fish-MIP), we analyzed future trajectories of climate-change impacts on marine animal biomass and associated environmental drivers across the North Atlantic Ocean and within the North west Atlantic Fisheries Organization (NAFO) convention area and evaluated potential consequences for fisheries productivity and management. Our ensemble results showed that the magnitude of projected biomass changes increased over time and from a low (RCP2.6) to high (RCP8.5) emissions scenario. Within individual NAFO divisions, however, projected biomass changes differed in the magnitude and sometimes direction of change between near (the 2030s) and far future (the 2090s) and contrasting emissions scenarios. By the 2090s, most NAFO divisions with historically (1990−1999) high fisheries landings were projected to experience biomass de creases of 5−40%, while Arctic and subarctic divisions with lower historical landings were projected to experience biomass increases between 20 and 70% under RCP8.5. Future trajectories of sea surface temperature and primary production corroborated that the far-future, high-emissions scenario poses the greatest risk to marine ecosystems and the greatest challenges to fisheries management. Our study summarizes future trends of marine animal biomass and underlying uncertainties related to model projections under contrasting climate-change scenarios. Understanding such climate-change impacts on marine ecosystems is imperative for ensuring that marine fisheries remain productive and sustainable in a changing ocean. OPEN ACCESS Projected changes in harvestable marine animal biomass under 21st century climate change in the NAFO convention area (high emissions scenario). Image: A. Bryndum-Buchholz
SoFIA: From a Content-based to Competency-based Educational Paradigm

This paper is an attempt to show that in the educational system of the 21st century, four conditions must be met for its successful present and future: an educational philosophy that can provide an operating pedagogical framework to address the issues of educational experience and the appropriate principles and values in teaching and learning; a path to excellence in order to create innovative practices in the teaching and learning environment within which all pedagogical operations can take place; a technology integration instrument with which the fundamental educational needs and their attendant changes can be attained; and a leading in action process, which can allow new concepts and ideas to be able to be realized. But most importantly these requirements force upon the education system the need to work within an educational paradigm which is a susceptible to such necessities. This paper presents and describes such a paradigm, named SoFIA which seeks to satisfy the conditions mentioned above. It suggests an educational philosophy offering an operating pedagogical framework to address the issues of educational experience and the appropriate principles and values in teaching and learning. The SoFia paradigm defines a path to excellence by creating innovative practices in the teaching and learning environment within which all pedagogical operations can take place. It outlines, moreover, a technology integration instrument with which the fundamental educational needs and their attendant changes can be attained; and a leading in action process whereby new concepts and ideas can be transformed into reality.
Mechanism of resistance to bactericidal fatty acids in Staphylococcus aureus

2. When an image on the film is obliterated w ith a round black mark, it is an indication o f either blurred copy because o f movement during exposure, duplicate copy, o r copyrighted materials that should not have been filmed. For blurred pages, a good image o f the page can be found in the adjacent frame. I f copyrighted materials were deleted, a target note w ill appear listing the pages in the adjacent frame.
ASCORBIC ACID CONTENT ON Hibiscus sabdariffa L. CALLUS AT VARIOUS CONSENTRATION OF SUCROSE IN MS MEDIA

Ascorbic acid is an antioxidant which is found in rosella flower. Its production through conventional method needs long time and wide field, so an alternative method through development of callus invitro is conducted. Sucrose is a main carbon source in MS medium and this sugar plays role as precursor for the formation of ascorbic acid. This study was conducted to determine the effect of sucrose concentration on callus formation and production of ascorbic acid. Sucrose was added to the media at the concentration of 20 g/L, 30 g/L, 40 g/L and 50 g/L. The culture was incubated for 42 days with twice subculture every 10 days. Analysis of ascorbic acid was perfomed using iodometry. The results showed that the callus was grow better in sucrose of 20 g/L while the ascorbic acid production was better in sucrose 50 g/L.
Process development of water-based polyurethane with acrylate terminal group under water vapor permeability and water repellency for nylon fabric

This study synthesized water-based polyurethane with acrylate terminal group (WPUA) using the long carbon chain of stearyl acrylate to synthesize hydrophobic poly-stearyl acrylate (PSA). The proposed process could minimize environmental pollution caused by fluorine-containing monomers. As a water-based polyurethane (WPU) end-capping agent, the hydrophobic PSA and the hydrophilic and water vapor permeable WPU are copolymerized to form a WPUA functional resin with simultaneous water vapor permeability (WVP) and water repellency. Here, 2-mercaptoethanol was used to control the molecular weight of PSA to prepare the acrylate end-capping agent. PSA was then employed in WPU to form WPUA, which is characterized by the moisture permeability of WPU and water repellency of acrylic resin simultaneously. During the WPUA process, dimethylacetamide was used as a neutralizer to replace the traditional toxic chemical control drug triethylamine. This study set up the material and chemical structure to replace the toxic chemical-controlled drugs and organofluoride in the traditional preparation of moisture permeable and water repellent materials. The proposed process was proven to reduce the consumption of organic solvent, achieve WPUA copolymer stability, and provided moisture permeable and water repellent functions. In addition, Fourier transform infrared spectroscopy was used to determine the structure of WPUA, while thermogravimetry analysis and differential scanning calorimetry were performed to establish the thermal properties of WPUA. After the WPUA was padded on nylon fabric, its water drop contact angle was observed through a scanning electron microscope. The results showed that the contact angle of nylon fabric increased significantly, water repellency was reached, and WVP rises by 23.75%.
Value Relevance of IFRS Adoption in ASEAN-5 Countries: Does Presentation Matters?

Research aims: This study discusses a recent development in the adoption of International Financial Reporting Standard (IFRS) in ASEAN. The objective of this study is to examine the value relevance of the Other Comprehensive Income (OCI) after the revision of the International Accounting Standard (IAS 1) about the presentation of financial statements. Primarily, this study will examine whether the relocation of the OCI from the Statement of Changes in Owners' Equity to the Statement of Comprehensive Income will increase the value relevance. Design/Methodology/Approach: This study compares the value relevance of other comprehensive income (OCI) one year before and after the adoption of IAS 1 in each country. The study focuses on ASEAN 5 countries, namely Indonesia, Malaysia, Philippine, Singapore, and Thailand. Research findings: The result of the study found that the OCI has higher value relevance after the adoption of IAS 1. Theoretical contribution/ Originality: . This study extends previous studies around IFRS adoption, which mostly focused on European countries. The study about IFRS adoption in ASEAN countries is limited. This study presents a unique setting since most of the Countries in ASEAN adopted IAS 1 not in the same year as the year enacted by the IASB. This study will contribute to the recent development in accounting standard, which shows the adoption of IAS No. 1 as part of the IFRS adoption in ASEAN will increase the value relevance of the financial statement. Practitioner/Policy implication: This study will imply for the Practitioner and Policymakers that the benefits of IFRS adoption aimed to improve the quality of financial reports, so users can more easily and readily process that information about company performance. Research limitation/Implication: This study only focuses on total OCI. This study does not analyze the impact of the adoption of revised IAS 1 for each items of OCI, such as available for sale component, revaluation surplus or translation component. The result is consistent with the proponent of the IFRS adoption that the revision of IAS 1 will increase the usefulness of the financial statement.
A Green Nutraceutical Study of Antioxidants Extraction in Cleome brachycarpa ­ An Ethnomedicinal Plant

In the present study, an indigenous medical plant ‘Cleome brachycarpa’ was comparatively investigated for its antioxidant extraction for first time; using the soxhlet (traditional), microwave-assisted, and ultrasound-assisted (green) extraction methods with seven different solvents. The microwave-assisted extraction with methanol as solvent recovered the phytochemicals two-folds higher than the other methods with extraction efficiency of 370.57 ± 0.49 μg/ mg and correspondingly extracted the polyphenols: Phenolics (74.17 ± 0.61 μg GAE/mg DW), Flavonoids (65.46 ± 0.40 μg QE/mg DW), and Tannins (55.97 ± 0.85 μg CE/mg DW). The antioxidant capacity in relation with polyphenols was determined for Free radical scavenging activity and total antioxidant potential. The DPPH radical scavenging percentage of methanolic green extract of Cleome brachycarpa was found to be 81.37 ± 0.28 with IC50 of 0.30 mg/mL that matched up to the DPPH scavenging potential of Trolox. Furthermore, the ferric reducing potential was high up to 15.30 ± 0.30 μg GAE/mg DW. The correlation of antioxidant capacity with polyphenols was highly significant (p < 0.05). The green nutraceutical study has validated the ethnomedicinal importance of Cleome brachycarpa which is related to its high polyphenolic content. The findings highlight Cleome brachycarpa as a potential candidate for research and isolation of medicinal polyphenols.