Miracle-dz/UniFAR-FTUs huggingface dataset:
Impacto económico del tratamiento anticoagulante con antagonistas de la vitamina K en pacientes portadores de prótesis valvular metálica en posición mitral

Los resultados de esta tesis ponen de manifiesto que el grupo de pacientes anticoagulados por una protesis mitral metalica suponen una carga asistencial y economica importante. El manejo clinico de este grupo de pacientes es muy complejo, debido a su edad avanzada y a sus multiples comorbilidades y tratamientos concomitantes. Esto hace que el control terapeutico sea mas dificil por el impacto que tienen sobre la farmacocinetica de los antagonistas de la vitamina K. Una gran parte de esta carga lo representan las visitas de monitorizacion del tratamiento anticoagulante. Por otro lado, a pesar del numero importante de visitas que generan estos pacientes, en este trabajo se demuestra que solo en un 40,16% de las visitas los pacientes estaban bien anticoagulados. Estos resultados han mostrado un peor control de este grupo de pacientes comprado con los resultados de otros estudios realizados en grupos de pacientes con fibrilacion auricular no valvular, lo que supone que los pacientes portadores de protesis mitral metalica representan un grupo de dificil control terapeutico. Todo esto genera unos costes directos elevados en este grupo de pacientes.
Applicability of modified condition/decision coverage to software testing

Modified condition/decision coverage is a structural coverage criterion requiring that each condition within a decision is shown by execution to independently and correctly affect the outcome of the decision. This criterion was developed to help meet the need for extensive testing of complex Boolean expressions in safety-critical applications. The paper describes the modified condition/decision coverage criterion, its properties and areas for further work.
Design of a wide band slot antenna for GPS & dual band of WiMAX technology

In this paper, the design of a tri band slot antenna for L1 band of Global Positioning System (GPS), and two bands i.e. 3.5 GHz and 5.4 GHz of Worldwide interoperability for Microwave access (WiMAX) is proposed. The antenna consists of a rectangular slot with an area of 48 × 18 mm2. To provide different band of frequency, a T-shaped feed patch and an inverted T-shaped stub is used. The tri band is studied and designed using computer simulation with the aid of Ansoft HFSS design. The simulated result show that the antenna can be designed to cover the frequency band 1.52 to 1.6 GHz for the GPS System, and wide band of 3.06 - 3.99 GHz and 4.9 - 5.7 GHz for the dual band of WiMAX application. The proposed antenna is fabricated on a 0.8 mm thick substrate with a relative permittivity of 4.4. The paper includes the simulated results of return loss, VSWR and radiation patterns at all resonant frequencies.
Membrane lipids in plant-associated bacteria: their biosyntheses and possible functions.

Membrane lipids in most bacteria generally consist of the glycerophospholipids phosphatidylglycerol, cardiolipin, and phosphatidylethanolamine (PE). A subset of bacteria also possesses the methylated derivatives of PE, monomethylphosphatidylethanolamine, dimethylphosphatidylethanolamine, and phosphatidylcholine (PC). In Sinorhizobium meliloti, which can form a nitrogen-fixing root nodule symbiosis with Medicago spp. , PC can be formed by two entirely different biosynthetic pathways, either the PE methylation pathway or the recently discovered PC synthase pathway. In the latter pathway, one of the building blocks for PC formation, choline, is obtained from the eukaryotic host. Under phosphorus-limiting conditions of growth, S. meliloti replaces its membrane phospholipids by membrane-forming lipids that do not contain phosphorus; namely, the sulfolipid sulfoquinovosyl diacylglycerol, ornithine-derived lipids, and diacylglyceryl-N,N,N-trimethylhomoserine. Although none of these phosphorus-free lipids is essential for growth in culture media rich in phosphorus or for the symbiotic interaction with the legume host, they are expected to have major roles under free-living conditions in environments poor in accessible phosphorus. In contrast, sinorhizobial mutants deficient in PC show severe growth defects and are completely unable to form nodules on their host plants. Even bradyrhizobial mutants with reduced PC biosynthesis can form only root nodules displaying reduced rates of nitrogen fixation. Therefore, in the cases of these microsymbionts, the ability to form sufficient bacterial PC is crucial for a successful interplay with their host plants.
VITALISERINGSPSYKOLOGISK TILGANG TIL GENOPRETTENDE RET I ARBEJDET MED UNGE, DER BEGÅR KRIMINALITET

Med afsæt i en klarlægning af principperne i genoprettende ret og en diskussion af disse sat op imod den traditionelle strafferet vil artiklen vise, hvordan en vitaliseringspsykologisk tilgang kan bidrage til at kvalificere indholdsdelen af det konkrete arbejde med genoprettende ret i forhold til kriminelle unge og deres ofre. Artiklen er første skridt i retning af at skabe en fælles forståelsesramme for offer og gerningspersons forskellige situationer, der kan anvise en ny helhedsorienteret tilgang til arbejdet med unge kriminelles livsbaneudvikling. Med den foreslåede tilgang lægges der vægt på den læring, som kan finde sted i mødet mellem offer og gerningsperson, og der lægges vægt på den positive forandringsskabende betydning, man som professionel kan få gennem et realitetskorrigerende arbejde, der skaber psykologisk iltende betingelser for, at de unge kan opleve sig set, hørt og mødt ligeværdigt på det, som ligger bag deres kriminelle handlinger. Der lægges op til, at man i det kriminalpræventive arbejde med unge kriminelle fokuserer på de fællesmenneskelige psykologiske grundbehov – som eksisterer både for offer og gerningsperson – og på de professionelles kapacitet til at skabe medspillende modspil for de unges fremadrettede livsbaneudvikling.
Closed loop control system modeling of Permanent Magnet Brushless DC Motor

In this paper the more precise mathematical modeling of Permanent Magnet Brushless DC Motor (PMBLDC) has been presented. This is required for accurate real time applications of PMBDLC drive. The electronic and communication system of this motor drive is a power processing unit (PPU). The technological growth of the 21st century in microelectronics and control has resulted in powerful linear integrated circuits, microcontrollers and digital signal processors. In addition, the development in semiconductor technology also made it possible to significantly handle the voltage and current capabilities and the switching speeds of semiconductor devices which are the integral part of the Power Processing Unit (PPU). The Digital Signal Processors (DSPs) are used for real-time control. This requires efficient performance of the control for which steady state and transient model of the PMBLDC motor are necessary. The developed model is simulated using Matlab/ Simulink to confer the operating behavior of the drive prior to the implementation.
Piecewise H/sub /spl infin// controller design of discrete time fuzzy systems

This paper presents a new H/sub /spl infin// controller design method for the discrete time fuzzy systems based on the piecewise Lyapunov functions. The basic idea of the proposed approach is to construct the controller for the fuzzy systems in such a way that a discrete time piecewise Lyapunov function can be used to establish the global stability with H/sub /spl infin//- disturbance attenuation performance of the resulting close loop fuzzy control systems. It is shown that the control laws can be obtained by solving a set of linear matrix inequalities (LMIs) that is numerically tractable with commercially available software. Numerical example is given to demonstrate the advantage of the proposed method.
Facial performance capture and expressive translation for King Kong

Expression space has several benefits. It provides a transcription of the communicative content of the performance, and is ideal to map in an art-directable way to a topologically different character. It provides an intuitive format for motion editing and making performance changes. Because the face is constrained in its motion, fitting to an expression space significantly reduces noise and allows for intelligent filtering.
Caractérisation épigénétique du lymphome du manteau

Les lymphomes du manteau (MCL) sont des lymphomes B a petites cellules, rares et particuliers de par leur pronostic sombre et leur evolution rapide (mediane de survie de 3-4 ans). Les objectifs cles autour de cette maladie sont : l'identification de marqueurs moleculaires predictifs de l'evolution et le developpement de therapies innovantes. De nombreuses etudes ont etaye le role preponderant d'anomalies epigenetiques dans l'initiation et la progression des cancers. L'interet de ce projet est d'etablir le profil epigenetique du lymphome du manteau, d'identifier les localisations des anomalies observees et d'etudier les genes modificateurs de la methylation des histones. De facon tout a fait remarquable, les observations faites en immunohistochimie sur ganglions lymphatiques reactionnels pointent le role important de la dynamique du remodelage de la chromatine, en particulier pour H4K20me3, au cours de la proliferation / differentiation lymphoide B antigene-dependante. Nous avons identifie des cas de MCL pour lesquels le patron observe dans les hyperplasies ganglionnaires est largement perturbe. En effet, sur une serie de 19 patients, il coexiste deux profils distincts pour la marque d'heterochromatine constitutive H4K20me3, des cas negatifs et des cas fortement positifs. L'hypothese d'une deregulation de l'expression des enzymes mettant en place ou effacant ces marques ne semble pas evidente. Les alterations de l'heterochromatine constitutive apparaissent desormais comme une perturbation epigenetique recurrente dans le MCL. Ces profils epigenetiques pourraient permettre de degager des marqueurs pronostiques pertinents et de developper de nouvelles strategies therapeutiques ciblees.
Contrôle de la conformité de l'information financière des sociétés cotées aux normes comptables par l'AMF en France : Analyse comparative avec deux modèles anglo-américains (la SEC et le FRRP)

L'objectif de cet article est d'analyser les methodes de controle de l'information financiere des societes cotees par les autorites de surveillance dans le contexte europeen ou les normes IFRS sont devenues obligatoires pour la preparation des etats financiers consolides. Le systeme de controle de l'AMF est developpe de maniere approfondie, dans une perspective comparative avec deux modeles anglo-americains (la SEC et le FRRP). La methodologie suivie est qualitative s'appuyant sur l'observation empirique a l'AMF completee par les entretiens avec les controleurs impliques dans la verification des etats financiers d'emetteurs. Si les recherches recentes discutent de la surveillance de l'application des normes IFRS par les regulateurs, a notre connaissance, peu de travaux cherchent a mettre en avant la valeur technique de cette ligne de controle. Notre etude interesse particulierement les differents participants sur les marches financiers, tels que les regulateurs, les auditeurs, les preparateurs et les utilisateurs de l'information financiere.
Rapid non‐genomic effects of glucocorticoids on oxidative stress in a guinea pig model of asthma

Background and objective: Glucocorticoids (GC) may exert therapeutic effects in asthma by a rapid non‐genomic mechanism. The lungs of asthmatic patients are exposed to oxidative stress, which is believed to be critical in the pathogenesis of asthma. The aim of this study was to investigate whether GC exert a rapid non‐genomic effect on oxidative stress in asthmatic guinea pigs.
A survey on helminthic infection in mice (Mus musculus) and rats (Rattus norvegicus and Rattus rattus) in Kermanshah, Iran

Parasitic infections of rodents can compromise scientific research as well as the health of the animals and humans. Based on previous studies, infection rate of parasitic helminths is different in various regions of Iran. The current survey was aimed to determine endoparasitic helminths infection in 138 trapped rodents of Kermanshah county, Iran. Mice and rats were trapped using metal snares from January to October 2011 and euthanized. Rodents included 110 Mus musculus (79.00%), 23 Rattus norvegicus (17.00%), and five Rattus rattus (4.00%). The gastrointestinal and respiratory tracts were removed and examined to identify parasitic helminths. The results indicated that 42.02% of examined rodents were infected with eight helminths species, i.e. Trichuris muris (14.49%), Syphacia obvelata (13.76%), Syphacia muris (2.89%), Aspicularis tetrapetra (5.07%), Heterakis spumosa (5.07%), Capillaria hepatica eggs (3.62%), Hyminolepis diminuta (12.30%), and Cystisercus fasciolaris, the larva of Taenia teanieformis (4.34%). Given the results of this study, we concluded that examined rodents were more infected with nematodes than other helminths. As rodents are usually infected with a number of zoonotic parasites, hence control of these animals has an important role in safeguarding public health.
Poverty Point Sites in Southeastern Louisiana

Abstract Two small shell middens, containing numerous Poverty Point objects and associated with a 4000-year-old subdelta of the Mississippi River, have been located in the Pontchartrain Basin. Dated by the radiocarbon method at approximately 1740 B.C., the sites have been established as a separate phase of the Poverty Point horizon. A third site, characterized by abundant imported stone and a well-developed microflint industry, is believed to be contemporaneous with the Poverty Point and Jaketown sites.
Experimental observation of a generalized Gibbs ensemble

Detecting multiple temperatures Most people have an intuitive understanding of temperature. In the context of statistical mechanics, the higher the temperature, the more a system is removed from its lowest energy state. Things become more complicated in a nonequilibrium system governed by quantum mechanics and constrained by several conserved quantities. Langen et al. showed that as many as 10 temperature-like parameters are necessary to describe the steady state of a one-dimensional gas of Rb atoms that was split into two in a particular way (see the Perspective by Spielman). Science, this issue p. 207; see also p. 185 Interferometry suggests that as many as 10 parameters are needed to describe the steady state of an integrable system. [Also see Perspective by Spielman] The description of the non-equilibrium dynamics of isolated quantum many-body systems within the framework of statistical mechanics is a fundamental open question. Conventional thermodynamical ensembles fail to describe the large class of systems that exhibit nontrivial conserved quantities, and generalized ensembles have been predicted to maximize entropy in these systems. We show experimentally that a degenerate one-dimensional Bose gas relaxes to a state that can be described by such a generalized ensemble. This is verified through a detailed study of correlation functions up to 10th order. The applicability of the generalized ensemble description for isolated quantum many-body systems points to a natural emergence of classical statistical properties from the microscopic unitary quantum evolution.
Self-Care Behaviors of African Americans with Heart Failure: A Photovoice Project

SELF-CARE BEHAVIORS OF AFRICAN AMERICANS WITH HEART FAILURE: A PHOTOVOICE PROJECT Aimee Woda PhD (c), RN BC Marquette University 2012 The purpose of this dissertation study was to gain a better understanding of the subjective experience of low-income, urban dwelling, African Americans with heart failure. Outlining both the perceived facilitators and barriers related to engaging in heart failure self-care behaviors. The theoretical framework for this study was founded on the principles of education for critical consciousness. This study utilized a mixed methods descriptive research design and the photovoice methodology. Ten low-income African Americans with heart failure were recruited from three public housing buildings. The participants’ mean age was 67.5. Their average annual income was $13,537. Participants were provided with digital cameras and instructed to take photographs of what they do to take care of themselves, what makes it easy, and what makes it difficult. The participants and the researcher met for two hours per week for six weeks to discuss the photographs that were taken each week. Additionally, participants completed the Personal Health Questionnaire (PHQ-9) depression severity screening tool and the Self-Care of Heart Failure Index (SCHFI) on week 1 and week 6. Commonly reported maintenance behaviors included adhering to medications, following dietary restrictions, and participating in daily physical activity. Three themes emerged concerning the facilitators: family support gives me the push I need, social interaction lifts me up, and support in my environment has allowed me to better my condition. An additional subtheme—personal benefits of the environment—was identified within the third theme. Four themes emerged as the barriers: depression slows my heart down, interruption in health care provider, neglected environment, and dietary challenges. The findings from this study provide a deep understanding of the importance of social support from family, friends, and health care providers in improving self-care maintenance behaviors. Additionally, inescapable environmental constraints were identified as interfering with engagement. These findings may assist nurses in understanding the complexity of heart failure self-care among low-income African Americans living in urban settings. Understanding individual self-care behaviors, facilitators, and barriers of those with heart failure can lead to the development of appropriate patient-centered assessments and interventions.
Molecular Imaging of MDM2 Messenger RNA with 99mTc-Labeled Antisense Oligonucleotides in Experimental Human Breast Cancer Xenografts

The mouse double-minute 2 (MDM2) oncogene, amplified or overexpressed in many human cancers, has been suggested to be a novel target for cancer therapy. Visualization of MDM2 expression using radionuclide targeting can provide important diagnostic information in malignant tumors. The overall aim of this study was to evaluate whether liposome-coated 99mTc-radiolabeled antisense oligonucleotides (ASONs) targeting MDM2 messenger RNA (mRNA) could be used for imaging of MDM2 expression in vivo. Methods: ASON and mismatch oligonucleotide (ASONM) targeted to MDM2 mRNA were synthesized and radiolabeled with 99mTc using the bifunctional chelator hydrazinonicotinamide (HYNIC). Then the radiolabeled probe was characterized in vitro. Reverse-transcriptase polymerase chain reaction and Western blotting were performed to assay the MDM2 mRNA and protein level after MCF-7 (human breast adenocarcinoma cell line) cells were incubated with liposome-coated 99mTc-HYNIC-ASON/ASONM at various concentrations for 24 h. Following established MCF-7–bearing nude mice models, the biodistribution of liposome-coated 99mTc-HYNIC-ASON/ASONM was investigated, and in vivo tumor scintigraphic images were acquired for these animal models. All data were analyzed by statistical software. Results: The labeling efficiencies of 99mTc-HYNIC-ASON and 99mTc-HYNIC-ASONM were 57.2% ± 2.98% and 56.3% ± 3.01%, respectively; the specific activities were 1,450 ± 60.2 and 1,370 ± 55.4 kBq/μg, respectively; and the radiochemical purity for both was above 95%. The radiolabeled ASON still had the ability to hybridize to the sense oligonucleotide. In comparison with the mismatch probe, the antisense probe had an obvious effect on the levels of MDM2 mRNA and protein. The levels of mRNA and protein were significantly different for different concentration antisense probe groups (P < 0.01). The excretion of the antisense and mismatch probe was mainly through the liver and kidneys. The tumor radioactivity uptake of the antisense probe was significantly higher than that of the mismatch probe (P < 0.01). At 1–10 h after injection of the antisense probe, the tumor could be clearly visualized, whereas the tumors were not imaged at any time after injection of the mismatch probe. Conclusion: The accumulation of liposome-coated 99mTc-labeled ASONs in breast cancer tissue is specific. The antisense imaging with liposome-coated 99mTc-HYNIC-ASON may be a promising method for visualization of MDM2 expression in human breast cancer.
Optimal Auditing for Insurance Fraud

This article makes a bridge between the theory of optimal auditing and the scoring methodology in an asymmetric information setting. Our application is meant for insurance claims fraud, but it can be applied to many other activities that use the scoring approach. Fraud signals are classified based on the degree to which they reveal an increasing probability of fraud. We show that the optimal auditing strategy takes the form of a "red flags strategy," which consists in referring claims to a special investigative unit (SIU) when certain fraud indicators are observed. The auditing policy acts as a deterrence device, and we explain why it requires the commitment of the insurer and how it should affect the incentives of SIU staffs. The characterization of the optimal auditing strategy is robust to some degree of signal manipulation by defrauders as well as to the imperfect information of defrauders about the audit frequency. The model is calibrated with data from a large European insurance company. We show that it is possible to improve our results by separating different groups of insureds with different moral costs of fraud. Finally, our results indicate how the deterrence effect of the audit scheme can be taken into account and how it affects the optimal auditing strategy.
The green economy and post‐growth regimes: opportunities and challenges for economic geography

Abstract While mainstream economic geography is doing increasing research on green manufacturing and services, with a few notable exceptions, its predominant conceptual approaches to emerging modes of economic orientation continue to examine economic transitions somewhat unreflexively within the context of traditional growth paradigms. The aim of this article is to explore and critically examine neoliberal discourses on the green economy and smart growth by exploring contributions to debates on green economics proposed by ideas linked to post‐growth economies. Based on studies by scholars such as Tim Jackson and Serge Latouche, the article examines the contours of debates on post‐growth, décroissance (de‐growth) and prosperity without growth. We begin by examining growth debates and existing contributions by economic and other geographers to the exploration of alternatives to conventional growth‐centred economics. We then identify some emergent spatial facets of post‐growth transitions and utilize these to explore potential research topics and opportunities for empirical and conceptual contributions by economic geographers to academic and societal debates on economic transitions and post‐growth paradigms. Particular attention is paid to approaches currently discussed in economic geography, such as socio‐technical transition studies.