Miracle-dz/UniFAR-FTUs huggingface dataset:
Mastoid Fossa Temperature Imbalances in the Presence of Interference Patterns: A Retrospective Analysis of 253 Cases

Objective: To determine how bilateral mastoid fossa asymmetry relates with other patterns of interference associated with vertebral subluxation analysis, employing state of the art thermography detection instrumentation. Design: Bilateral thermographic mastoid fossa data for this study was compiled retrospectively by paraprofessio nals from randomly selected ≥active patient files. ¥ A paraprofessio nal trained in paraspinal thermographic scanning randomly selected patient files making note of case numbers to preclude the possibility of duplication of patients. ≥Active patient files¥ are case records of patients receiving care on a scheduled basis in accordance with the established plan of care. The active patient files consisted of 552 case files. Mastoid fossa data were extracted from 139 randomly selected patient visits from among those wherein the doctor had identified the presence of patterns of interference and receiving atlas adjustments; and 114 randomly selected patient visits without patterns of interference. Methods: On all prior visits the following four criteria were used to determine the presence of a pattern of interference: cervical paraspinal thermographic scan; mastoid fossa temperature differential; spinal balance (Thompson-Derifield) leg length and cervical syndrome leg length tests. The TyTron® scanner, model C-3000 was used to compile all paraspinal thermographic data. The data was randomly collected from a population of 552 active patient files. 139 patient visits were selected that displayed patterns of interference and received atlas adjustments; and 114 patient visits without patterns of interference. Results: In the absence of patterns of interference a tendency toward bilateral mastoid fossa temperature symmetry (55.26% of cases) was observed. In the presence of patterns of interference there was less of a tendency for bilateral mastoid fossa Temperature symmetry (32.0% of cases). When asymmetry was found the average difference in fossa temperatures exceeded those observed using conventional tools. In patients displaying the presence of patterns of interference the fossa temperature tended to be cooler on the side of atlas vertebra laterality (SOL). It was also observed that the pre-adjustment balanced temperatures were fewer than the number of post -adjustment balanced temperatures. Conclusions: The data suggests that there is a tendency toward bilateral mastoid fossa thermographic symmetry, especially in the absence of patterns of interf erence. However, bilateral symmetry is less likely in the presence of interference patterns. Additionally, the magnitude of the temperature differential was found to be greater than experienced with earlier instrumentation. It was also noted that in the presence of interference patterns associated with atlas listings the mastoid fossa tends to be more frequently cooler on the side of atlas laterality.
2015 American Heart Association/American Stroke Association Focused Update of the 2013 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Regarding Endovascular Treatment: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

Purpose— The aim of this guideline is to provide a focused update of the current recommendations for the endovascular treatment of acute ischemic stroke. When there is overlap, the recommendations made here supersede those of previous guidelines. Methods— This focused update analyzes results from 8 randomized, clinical trials of endovascular treatment and other relevant data published since 2013. It is not intended to be a complete literature review from the date of the previous guideline publication but rather to include pivotal new evidence that justifies changes in current recommendations. Members of the writing committee were appointed by the American Heart Association/American Stroke Association Stroke Council’s Scientific Statement Oversight Committee and the American Heart Association/American Stroke Association Manuscript Oversight Committee. Strict adherence to the American Heart Association conflict of interest policy was maintained throughout the consensus process. Recommendations follow the American Heart Association/American Stroke Association methods of classifying the level of certainty of the treatment effect and the class of evidence. Prerelease review of the draft guideline was performed by 6 expert peer reviewers and by the members of the Stroke Council Scientific Statement Oversight Committee and Stroke Council Leadership Committee. Results— Evidence-based guidelines are presented for the selection of patients with acute ischemic stroke for endovascular treatment, for the endovascular procedure, and for systems of care to facilitate endovascular treatment. Conclusions— Certain endovascular procedures have been demonstrated to provide clinical benefit in selected patients with acute ischemic stroke. Systems of care should be organized to facilitate the delivery of this care.
Primary Thyroid Carcinoma with Low-Risk Histology and Distant Metastases: Clinicopathologic and Molecular Characteristics.

BACKGROUND Distant metastases (DM) are a rare occurrence in well-differentiated thyroid carcinoma. The aim of this study was to analyze the clinical, pathologic, and molecular features of primary thyroid carcinoma with low-risk histology that develop DM. METHODS A detailed clinicopathologic review and targeted next-generation sequencing were performed on a cohort of well-differentiated thyroid carcinoma lacking gross extrathyroidal extension, extensive vascular invasion, or significant lymph node metastases but exhibiting DM. RESULTS Primary well-differentiated thyroid carcinoma with low-risk histologic features and DM was a rare occurrence, accounting for only 3% of metastatic non-anaplastic thyroid carcinoma. All 15 cases meeting the inclusion criteria harbored DM at presentation. The majority (11/15) of these tumors were follicular variant of papillary thyroid carcinoma (PTC), especially the encapsulated form (n = 8). The remaining patients harbored encapsulated Hürthle cell carcinoma (n = 2), encapsulated follicular carcinoma (n = 1), and an encapsulated papillary carcinoma classical variant (n = 1). Of the 12 encapsulated carcinomas, 10 had capsular invasion only and no vascular invasion. Ninety-two percent of the tumors exhibited extensive intra-tumoral fibrosis. Among the eight tumors that were subjected to next-generation sequencing analysis, a RAS mutation was the main driver (5/8), and TERT promoter mutation was highly prevalent (6/8). In four cases, TERT promoter mutations were associated with RAS or BRAF mutations. BRAF-mutated classical variant of papillary carcinoma also presented with DM but was less common (1/8). In 11/15 cases, the clinician was able to diagnose distant disease based on the clinical presentation. In 3/4 incidental cases that were genotyped, TERT promoter mutations were found. CONCLUSIONS When DM occur in primary thyroid carcinoma with low-risk histology, they are almost always found at presentation. The majority are encapsulated follicular variant of PTC with capsular invasion only. TERT promoter mutations occur at a higher rate than that seen in PTC in general and may help explain the aggressive behavior of these histologically deceptive primary carcinomas.
Researchn effects of picroside 2 in cerebral ischemic injury rats

Background: Excitatory amino acid toxicity, oxidative stress, intracellular calcium overload, as well as inflammation and apoptosis are involved in the pathological process after cerebral ischemic reperfusion injury. Picrodide 2 could inhibit neuronal apoptosis and play anti-oxidant and anti-inflammation role in cerebral ischemia/reperfusion injuries, but the exact mechanism is not very clear. This study aims to explore the anti-inflammation mechanism of picroside 2 in cerebral ischemic reperfusion injury in rats. Methods: The middle cerebral artery occlusion reperfusion models were established with intraluminal thread methods in 90 adult healthy female Wistar rats. Picroside 2 and salvianic acid A sodium were respectively injected from tail vein at the dosage of 10 mg/kg for treatment. The neurobehavioral function was evaluated with Bederson's test and the cerebral infarction volume was observed with tetrazolium chloride (TTC) staining. The apoptotic cells were counted by in situ terminal deoxynucleotidyl transferase-mediated biotinylated deoxyuridine triphosphate nick end labeling (TUNEL) assay. The immunohistochemistry stain was used to determine the expressions of toll-like receptor 4 (TLR4), nuclear transcription factor κB (NFκB) and tumor necrosis factor α (TNFα). The concentrations of TLR4, NFκB and TNFα in brain tissue were determined by enzyme linked immunosorbent assay (ELISA). Results: After cerebral ischemic reperfusion, the rats showed neurobehavioral function deficit and cerebral infarction in the ischemic hemisphere. The number of apoptotic cells, the expressions and the concentrations in brain tissue of TLR4, NFκB and TNFα in ischemia control group increased significantly than those in the sham operative group (P 0.05).
AVALIAÇÃO DA DENSIDADE MINERAL ÓSSEA EM CRIANÇAS E ADOLESCENTES COM DOENÇA CELÍACA

During the past few years, growing evidence demonstrate that celiac disease (CD) leads to bone abnormalities and consequently to pathological fractures. A lot of studies on bone metabolism performed on adult patients with celiac disease demonstrate that a gluten free diet is not the only variable responsible for bone mineral density recovery. There are only a few studies published in the pediatric population and the results are controversial. The aim of this study was to compare bone mineral density in children and adolescents with celiac disease with a control group and to determine the possible factors involved in bone mineral density reduction, like non-adherence to diet, late diagnosis, presence of comorbidities and low intake of calcium and vitamin D. This study also correlates bone mineral density results with bone metabolism biochemistry in celiacs. Forty celiac patients followed at Hospital de Clínicas UFPR were evaluated, independent of gender, aged between 4 and 21 years and with a diagnosis of CD for at least one year. Twenty one healthy patient's siblings, aged between 4.3 and 20.2 years were used as controls. The tests realized included DXA, bone age RX, bone metabolism biochemistry, nutrition evaluation and calcium and vitamin D intake by a 24-hour recall as well as food frequency questionnaire in celiacs and controls. In the nutrition evaluation a significant difference in agefor-height Z score was observed, -1.1 for celiacs vs. -0.48 for controls. A significant difference in lumbar spine and whole body Z scores between celiacs and controls was also observed, and this difference persisted after correcting for bone age. In the celiac group low bone mineral density for chronological age in lumbar spine and whole body (Z score < -2) was seen in 6 patients. On analyzing the possible variables that could explain these differences in bone mineral density between the groups, was demonstrated that late diagnosis exerted a negative influence in bone mass. Non-adherence to gluten free diet and low calcium intake also worsened bone mass in these patients.
Urinary Hepcidin Excretion in Patients with Myelodysplastic Syndrome (MDS) and Myelofibrosis (MF).

One of the main features of patients with Myelodysplastic Syndrome (MDS) is severe anemia which requires multiple blood transfusions with consequent iron overload. Moreover, iron metabolism is impaired particularly in refractory anemia with ring sideroblasts (RARS). Hepcidin is a small, cysteine-rich cationic peptide produced by hepatocytes, secreted into plasma and excreted in the urine. Hepcidin control iron absorption in the gut, release of iron from macrophages and is a key regulator of iron metabolism. Patients with iron overload have elevated urinary hepcidin levels but patients with anemia or increased erythropoietic precursors have suppressed hepcidin. The purpose of this study was to measure hepcidin excretion in the urine of patients with MDS and Myelofibrosis (MF). The assay of urinary Hepcidin was performed by the method of Nemeth et al (J. Clin.Invest113:1271–1276, 2004) and expressed per mg urinary creatinine. The samples were obtained from 20 patients, 16 with MDS and 4 with MF. Their subtypes and age, ranging from 54 to 87 years, are shown in the table. Nine MDS patients received less than 10 units of blood and the rest, between 13 and 147 units. Seven MDS patients had ferritin levels above 1000 ng/ml and their transferrin saturation in most of them was more than 50%. The urinary excretion of hepcidin was low (less then 1 ng/mg creatinine) in 3 MDS and 3 MF patients, while in the rest, with the exception of 2 patients, the levels were less than 50 ng/mg creatinine. Although the degree of iron overload was not related directly to the subtype and to the number of blood units, in some patients mainly with RARS it was quite severe. More importantly, the urinary hepcidin excretion had a more consistent pattern of low levels in all the patients even in those with high ferritin or high transferrin saturation levels. Hepcidin concentrations correlated well with serum ferritin (r2 = 0.62 on a log-log plot) but the slope of the correlation was only 0.05 (normal ~ 1) indicating marked suppression of hepcidin relative to ferritin. Suppression of hepcidin in MDS and MF suggests that hepcidin deficiency could worsen the maldistribution of iron from the nontoxic form in macrophages to toxic forms in parenchymal cells, and that intestinal iron absorption as well as transfusional iron could contribute to their iron overload.
A Phase I/II Study with CP-4055 in Patients with Haematologic Malignancies.

Background: CP-4055 (ELACYT™, cytarabine 5′-elaidic acid ester) is a novel cytotoxic nucleoside analogue. While CP-4055 has similar mechanisms of action to cytarabine, it is, unlike cytarabine independent of nucleoside transporters for cellular uptake. This is the first study in patients with haematologic malignancies. CP-4055 is currently in Phase II studies in patients with solid tumors. Aims: Determination of the maximum tolerated dose and the preferred infusion time in patients with haematologic malignancies. Methods: The study was initiated in May 2006. Patients (pts) received IV CP-4055 over 2 hours (2 hr IV, Arm A) or 24 hours (CIV, Arm B) in a day 1–5 q3w schedule. The starting dose in Arm A was 300 mg/m²/day and in Arm B 200 mg/m²/day, with standard definitions of DLT for haematologic malignancies. Dosing increments were by 50% until non-haematologic toxicities, and thereafter increments were by 30%. Results: In the ongoing study, 40 pts [25 male, median age 60.5 yrs (range 25–77); ECOG PS 0–1: 32 pts, ECOG PS 2: 8 pts; AML 35 pts, BAL 1 pt, MDS 1 pt, ALL 2 pts, CML-BP 1pt, average 2–3 lines prior chemotherapy (range 0–7)] have been treated at 2 US and 1 European centres. Five patients are ongoing. Two treatment-related serious adverse events (SAE) have been observed. One patient experienced fever and one patient had transaminase increase. Both patients recovered from their SAE while still on the study. No DLT has been observed and dose escalation is ongoing at 1950 mg/m²/day in Arm A and at 1500 mg/m²/day in Arm B. Nausea, anemia, diarrhea and thrombocytopenia were the most common possibly related AEs. One patient (875 mg/m²/day Arm B) with CRp received one course of consolidation therapy. Five patients with stable disease/mild myelosuppression received more than 2 cycles of CP-4055: one pt (AML) received 4 cycles and four patients (3 AML, 1 CML-BP) received three cycles. One of these patients was referred to stem cell transplantation. Fifteen patients received 2 cycles of therapy. Summary/Conclusion: Patients with haematologic malignancies tolerated CP-4055 well up to a dose of 1500 mg/m²/day (2 hr IV) and 1150 mg/m2/day (CIV) in a d1–5 q3w schedule. Myelosuppression has been observed with minimal toxicity. Accrual is ongoing.
[Adverse outcome screening in hospitalizations of the Brazilian Unified Health System].

OBJECTIVE To assess the frequency of screening for potential adverse outcomes in hospitalizations of the Brazilian Unified Health System. METHODS A retrospective study, including all hospital admissions of adults in medical clinics (n = 3,565,811) and surgical clinics (n = 2,614,048) in Brazil in 2007. The Hospital Information System was used as a source of information. The measurement of adverse events was based on screening for eleven clinical conditions, as defined by previous international studies, recorded in the secondary diagnosis field. We performed bivariate and multivariate analysis to investigate associations between adverse events, death (dependent variable) and other variables such as age, use of the intensive care unit and performance of surgery. RESULTS The frequency obtained for both clinic types was 3.6 potential adverse events per 1,000 admissions, with a greater frequency in medical clinics (5.3 per 1,000) than in surgery clinics (1.3 per 1,000). There were differences in the profile of hospital admissions between the two clinics: medical clinics were characterized by a predominance of older adults, longer average length of stay, higher mortality rate and lower total cost of hospitalization. The most common potential adverse outcome was hospital-acquired pneumonia. Cardiac arrest had a higher risk of death (OR= 5.76) compared to other potential adverse outcomes. Increased cost for hospitalizations was associated with sepsis. The conditions used as the screening criteria were associated with greater odds of death even after the introduction of variables such as use of intensive care and surgery. CONCLUSIONS The high frequency of adverse outcomes in hospital admissions indicates a need to develop monitoring strategies and to improve quality of care for improved patient safety.
ROLE OF ALPHA TOCOPHEROL AS AN ADJUVANT THERAPY IN PREGNANCY INDUCED HYPERTENSION

Hypertension is the most common medical problem encountered in pregnancy and remains an important cause of maternal and fetal morbidity and mortality. To conduct a clinical study to evaluate the adjuvant effect of alpha-tocopherol along with routine hypertensive measures in patients with pregnancy induced hypertension. A total of 25 pregnancy induced hypertensive patients with single fetus were prospectively followed up from 24 to 28 weeks of pregnancy till the end of pregnancy. The patients were given capsule alpha-tocopherol 400mg/day as adjuvant therapy. The base line readings and then at 4 weekly intervals of maternal blood pressure and platelets count and evaluated statistically till the end of pregnancy. The mean systolic blood pressure and diastolic blood pressure decreased by 3.5% and 4.36% respectively with significant p value <0.01. The platelet count increased by 5.98% though statistically non significant. Maternal blood pressure decreased and platelet count increased by oral supplementation of alpha tocopherol. Therefore the effect of alpha-tocopherol on these parameters should be considered in future for longer duration and larger scale studies.
Relation Extraction among Multiple Entities Using a Dual Pointer Network with a Multi-Head Attention Mechanism

Many previous studies on relation extrac-tion have been focused on finding only one relation between two entities in a single sentence. However, we can easily find the fact that multiple entities exist in a single sentence and the entities form multiple relations. To resolve this prob-lem, we propose a relation extraction model based on a dual pointer network with a multi-head attention mechanism. The proposed model finds n-to-1 subject-object relations by using a forward de-coder called an object decoder. Then, it finds 1-to-n subject-object relations by using a backward decoder called a sub-ject decoder. In the experiments with the ACE-05 dataset and the NYT dataset, the proposed model achieved the state-of-the-art performances (F1-score of 80.5% in the ACE-05 dataset, F1-score of 78.3% in the NYT dataset)
A Survey on Reconstructing Precise Sound Wave for Speechless Video

This paper deals with generating/reconstructing an intelligible audio for speechless recorded video by a person. There are many artificial intelligent techniques available for Automatic Speech Recognition (ASR) development. As the speech recognition technologies is improving the new sound wave is a hybrid, created from different types of sound waves. With further development, this new class of sound wave could be revolutionary in mapping audio for speechless video of a person to form a correct visual speech. Speech based applications are getting enormous popularity by incorporating Natural Language Processing (NLP) techniques. This paper discusses brief survey to the speech reconstruction techniques and provides a brief description about the different stages where the speech reconstruction techniques can be employed.
Application Service Provider LMS: an economic approach to ensure interoperability between learning management systems and the sharing of learning services and resources

In this paper, we propose an innovative concept of "Application Service Provider LMS (ASP LMS)" which promotes the opening and the interoperability of the learning management systems (LMS) and the sharing of learning services and resources. The goal of this opening is to make the interaction between systems easier, to facilitate the sharing of resources and services between systems. With the introduction of this economic model this system widens the market of the Open and Distance Learning (ODL).
A review of the seabirds of Phillip Island in the Norfolk Island Group

Few places have been as ecologically devastated by the introduction of exotic mammals as Phillip Island in the Norfolk Island Group. Pigs (Sus scrofa), goats (Capra hircus) and rabbits (Oryctolagus cuniculus) denuded the island so severely that massive amounts of soil and underlying substrate were lost through erosion. Rabbits, the last of these exotic animals to be removed, were eradicated during the 1980’s. Since then the extent of vegetation on the island has been increasing by natural revegetation and through plantings and seeding. Fourteen species of seabird currently breed on Phillip Island. Five species—Providence petrel (Pterodroma solandri), Kermadec petrel (P. neglecta), white-naped petrel (P. cervicalis), flesh-footed shearwater (Puffinus carneipes) and red-tailed tropicbird (Phaethon rubricauda)—all have ecologically significant populations. In this paper, we review the current status of the seabird populations breeding on Phillip Island, and suggest how vegetation restoration is likely to affect each species. We update previously published notes and present unpublished material collected by us over more than 3 decades. We document when each species was first discovered, reveal the location of nesting sites, describe breeding phenology and nesting habitat, report on any banding activities and returns, and discuss potential threats. Priddel, D. ; Carlile, N. ; Evans, O. ; Evans, B. ; McCoy, H. 2010. A review of the seabirds of Phillip Island in the Norfolk Island Group. Notornis 57(3): 113-127.