Miracle-dz/UniFAR-FTUs huggingface dataset:
Feasibility of group intervention for bereaved siblings after pediatric cancer death

ABSTRACT This study evaluated the feasibility (acceptability, recruitment, retention rates, treatment fidelity, and outcome measures) of implementing a manualized group intervention for bereaved siblings after pediatric cancer death. A convenience sample of 10 siblings participated. The intervention consisted of eight 2-hour sessions that focused on strategies for coping with grief, relationships, and emotional growth. Positive outcomes were obtained with respect to acceptability, recruitment, retention rates, and treatment fidelity. Preliminary outcomes were mixed. Parent pre- and post-intervention outcomes suggested improvements in siblings' overall emotional and social quality of life. Siblings' self-reports reflected no improvements. These data support the feasibility of conducting this intervention and suggest beneficial outcomes based on parental reports. Further research is recommended to evaluate the group intervention efficacy with a large sample using a randomized controlled trial to address the needs of bereaved siblings.
Feed-Forwardness of Spinal Networks in Posture and Locomotion

We present a new perspective on the concept of feed-forward compared to feedback mechanisms for motor control. We propose that conceptually all sensory information in real time provided to the brain and spinal cord can be viewed as a feed-forward phenomenon. We also propose that the spinal cord continually adapts to a broad array of ongoing sensory information that is used to adjust the probability of making timely and predictable decisions of selected networks that will execute a given response. One interpretation of the term feedback historically entails responses with short delays. We propose that feed-forward mechanisms, however, range in timeframes of milliseconds to an evolutionary perspective, that is, “evolutionary learning. ” Continuously adapting events enable a high level of automaticity within the sensorimotor networks that mediate “planned” motor tasks. We emphasize that either a very small or a very large proportion of motor responses can be under some level of conscious vs automatic control. Furthermore, we make a case that a major component of automaticity of the neural control of movement in vertebrates is located within spinal cord networks. Even without brain input, the spinal cord routinely uses feed-forward processing of sensory information, particularly proprioceptive and cutaneous, to continuously make fundamental decisions that define motor responses. In effect, these spinal networks may be largely responsible for executing coordinated sensorimotor tasks, even those under normal “conscious” control.
The Effect of Caffeine on Postprandial Hypotension in the Elderly

In a double‐blind, randomized trial the effects of caffeinated and decaffeinated drinks on postprandial hemodynamic and neurohumoral changes were studied in seven fit, elderly subjects after a standard 2.4MJ meal. There was a significant difference in supine postprandial systolic blood pressure between the placebo and caffeine phases (P < 0.01); at 60 minutes, supine systolic blood pressure had fallen 14 mmHg [95% confidence interval (CI) −7 to −11 mmHg, p < 0.01) after placebo, but was unchanged after caffeine (+9 mmHg, CI 0 to 18 mmHg, NS]. Similar differences between placebo and caffeine were seen in erect systolic and diastolic blood pressure (P < 0.01), although orthostatic tolerance was maintained throughout each study period. Postprandial plasma noradrenaline levels were higher (P < 0.02) and the increase greater (P < 0.02) after caffeine than after placebo. Caffeine administered at the end of a standard test meal prevents the postprandial fall in blood pressure in fit, elderly subjects. The clinical relevance of this finding has yet to be determined, but it may offer a simple remedy for patients with symptomatic postprandial hypotension.
Action recognition with temporal scale-invariant deep learning framework

Recognizing actions according to video features is an important problem in a wide scope of applications. In this paper, we propose a temporal scale-invariant deep learning framework for action recognition, which is robust to the change of action speed. Speciﬁcally, a video is firstly split into several sub-action clips and a keyframe is selected from each sub-action clip. The spatial and motion features of the keyframe are extracted separately by two Convolutional Neural Networks (CNN) and combined in the convolutional fusion layer for learning the relationship between the features. Then, Long Short Term Memory (LSTM) networks are applied to the fused features to formulate long-term temporal clues. Finally, the action prediction scores of the LSTM network are combined by linear weighted summation. Extensive experiments are conducted on two popular and challenging benchmarks, namely, the UCF-101 and the HMDB51 Human Actions. On both benchmarks, our framework achieves superior results over the state-of-the-art methods by 93.7% on UCF-101 and 69.5% on HMDB51, respectively.
An evaluation of the diagnostic value of different skin tests with egg in clinically egg‐allergic children having atopic dermatitis

Skin testing is a common diagnostic procedure in food allergy, but the final diagnosis of food allergy is based on the clinical response to food challenge. We studied the value of the skin prick‐prick test (SPT), skin application food test (SAFT) and atopy patch test (APT) with fresh egg extract in diagnosing egg allergy. Ten clinically egg‐allergic children with atopic dermatitis (AD; age 10 months to 8.4 yr, mean 3.4 yr) and 10 egg‐tolerant children with and 10 without AD (age 2.4–11 yr, mean 5.5 yr) participated. In SAFT several false‐negative reactions were seen, whereas all clinically egg‐allergic children were positive in SPT and 40–60% in APT. In APT and in SPT false‐positive reactions to egg were observed. In this study comprising a small number of patients including control subjects, neither SAFT nor APT with fresh whole egg extract were able to increase the diagnostic accuracy in detecting egg‐allergic children with AD compared with SPT.
A Life Course Approach to Understanding Poverty among Older American Adults

A relatively new strategy for studying the prevalence of poverty in America is to analyze it as a potential life course event. This approach is used in order to examine the likelihood of both income and asset poverty for individuals between the ages of 60 and 90. Nearly half of all elderly Americans will encounter at least 1 year of poverty or near poverty across these ages. In addition, 58% of those between the ages of 60 and 84 will at some point fail to have enough liquid assets to allow them to weather an unanticipated expense or downturn in income. The policy and practice implications of these findings are discussed.
Bone marrow cells from myelodysplastic syndromes show altered immunophenotypic profiles that may contribute to the diagnosis and prognostic stratification of the disease: A pilot study on a series of 56 patients

A heterogeneous spectrum of immunophenotypic abnormalities have been reported in myelodysplastic syndromes (MDS). However, most studies are restricted to the analysis of CD34+ cells and/or other major subsets of CD34− cells, frequently not exploring the diagnostic and prognostic impact of immunophenotyping.
Plataforma de recomendación de contenidos para libros electrónicos inteligentes basadas en el comportamiento de los usuarios.

Un sistema de recomendacion de contenidos basado en las relaciones colectivas de sus usuarios asociados en comunidades de lectores de una red social, permite construir un conocimiento colectivo que ayudan a recomendar de forma automatica listas de contenidos a los usuarios de la plataforma social, de acuerdo a su comportamiento, preferencias y antecedentes de lectura. En este trabajo, proponemos un modelo para una plataforma de recomendacion de contenidos basado en las acciones y comportamiento de los usuarios de libros electronicos en una comunidad de lectores en la web que ayude a los usuarios a descubrir contenidos de su interes de forma automatica y con un minimo esfuerzo.
Genome Sequences of Two Klebsiella pneumoniae Isolates from Different Geographical Regions, Argentina (Strain JHCK1) and the United States (Strain VA360)

ABSTRACT We report the sequences of two Klebsiella pneumoniae clinical isolates, strains JHCK1 and VA360, from a newborn with meningitis in Buenos Aires, Argentina, and from a tertiary care medical center in Cleveland, OH, respectively. Both isolates contain one chromosome and at least five plasmids; isolate VA360 contains the Klebsiella pneumoniae carbapenemase (KPC) gene.
Replacement of N-glycosylation sites on the MHC class II E alpha chain. Effect on thymic selection and peripheral T cell activation.

MHC class II molecules play a central role in thymic selection of developing T cells, Ag presentation to immunocompetent CD4+ T cells, and T cell activation by superantigens. We have established transgenic A.CA mice expressing either the wild-type E alpha d molecule (E alpha/E beta), or an E alpha d molecule altered at an N-glycosylation site on the E alpha chain (residue 78, 78E alpha/E beta or residue 118, 118E alpha/E beta) to identify a possible role for carbohydrates in thymic selection and peripheral T cell activation. Striking differences were found among these transgenic mice. Although V beta 10+ T cells were selected positively in all three transgenic strains, positive selection of V beta 7+ T cells was impaired in 118E alpha/E beta transgenic mice. Spleen cells from both strains with mutant E alpha chains showed selective defects in presentation of peptides to particular T cell hybridomas. In contrast, neither mutation affected presentation of the superantigen Mycoplasma arthriditis mitogen. These results demonstrate that alterations in the glycosylation of class II E alpha chains might affect both central and peripheral T cell regulation.
Increased pain threshold following electroacupuncture: analgesia is induced mainly in meridian acupuncture points.

UNLABELLED Pain thresholds were determined before and after electroacupuncture of the dorsal aspect acupuncture points (AP) of the hand and non acupuncture points (NAP) located 15 mm from the traditional acupuncture points to assess changes in pain threshold thus provoked. METHODS In eight volunteers the pain threshold of specific points was determined before and after acupuncture in the Hegu point (L.I. 4), at the back of the hand. A pressure dolorimeter was used to evaluate pain threshold at the Yangxi (L.I. 5) and Quchi (L.I. 11) points and at sites 15 mm from them. The effects on pain threshold were also measured at Yingxiang (L.I. 20) on both sides. RESULTS Before electrostimulation there were no significant differences among the pain thresholds in both AP and NAP. After electrostimulation of the Yangxi point, pain threshold raised from 5.20 kg/sq.cm to 9.20 kg/sq.cm (p < 0.01); acupuncture at Quchi caused the threshold to increase from 5.36 kg/sq.cm to 9.20 kg/sq.cm (p < 0.01) and Yingxiang stimulation changed threshold from 2.63 kg/sq.cm to 3.83 kg/sq.cm (p < 0.051) at the point on the same side and from 2.26 kg/sq.cm to 3.90 kg/sq.cm (p < 0.05) in the opposite side. Before electroacupuncture the pain thresholds at all the tested sites were not statistically different (p > 0.1). After electrostimulation the pain threshold increased 77% at L.I. 5 but went up just 9% and 6% 15 mm from L.I. 5 (p < 0.01); threshold increased by 70% at L.I. 11 but only by 6% and 7% (p < 0.01) 15 mm from L.I. 11. CONCLUSIONS The pain threshold increased significantly in all tested sites after electroacupuncture but the analgesic effect was predominant in those points lying along the acupuncture meridians.
Atheists and Agnostics Are More Reflective than Religious Believers: Four Empirical Studies and a Meta-Analysis

Individual differences in the mere willingness to think analytically has been shown to predict religious disbelief. Recently, however, it has been argued that analytic thinkers are not actually less religious; rather, the putative association may be a result of religiosity typically being measured after analytic thinking (an order effect). In light of this possibility, we report four studies in which a negative correlation between religious belief and performance on analytic thinking measures is found when religious belief is measured in a separate session. We also performed a meta-analysis on all previously published studies on the topic along with our four new studies (N = 15,078, k = 31), focusing specifically on the association between performance on the Cognitive Reflection Test (the most widely used individual difference measure of analytic thinking) and religious belief. This meta-analysis revealed an overall negative correlation (r) of -. 18, 95% CI [-. 21, -. 16]. Although this correlation is modest, self-identified atheists (N = 133) scored 18.7% higher than religiously affiliated individuals (N = 597) on a composite measure of analytic thinking administered across our four new studies (d = .72). Our results indicate that the association between analytic thinking and religious disbelief is not caused by a simple order effect. There is good evidence that atheists and agnostics are more reflective than religious believers.
Auger recombination in heavily doped shallow-emitter silicon p-n-junction solar cells, diodes, and transistors

A rigorous analytic evaluation of an emitter model that includes Auger recombination but excludes bandgap narrowing is presented. It is shown that such a model cannot explain the experimentally observed values of the open-circuit voltage VOCin p-n-junction silicon solar cells. Thus physical mechanisms in addition to Auger recombination are responsible for the experimentally observed values of VOCin silicon solar cells and the common-emitter current gain in bipolar transistors.
Adaptive acid tolerance response in Salmonella enterica serovar Typhimurium and Salmonella enterica serovar Typhi

The survival of bacteria in various environments depends on a number of protective responses including acid tolerance response (ATR). In this study, ATR phenomenon was compared in Salmonella enterica serovar Typhi 6 and Salmonella enterica serovar Typhimurium 98 under different culture conditions. Survival of the adapted culture (pre‐acid shocked to pH 5.5) was significantly better (p < 0.05) as compared to control, unadapted culture after acid shock at pH 3.3. However, the ATR varied with the serovar, incubation temperature and the growth medium used (all p‐values < 0.05). S. Typhi 6 failed to grow in pH 3.3 at 45 °C. The addition of tetracycline or chloramphenicol (1.0 μg ml−1) to adapted cultures during or after acid shock (pH 3.3) had no effect on ATR expression. In S. Typhimurium 98, growth was increased by 10% or greater in adapted culture (when grown at pH 3.3) as compared to growth observed with an unadapted culture (when grown at pH 7.3) on transfer to fresh growth medium at pH 7.3. A poor ATR observed in non‐growing S. Typhimurium 98 suspensions clearly showed that ATR is an energy‐consuming process. Storage of S. Typhimurium 98 cultures in pH 4.5 nutrient broth at 4 °C demonstrated that prolonged exposure to acidic conditions is more detrimental in comparison to the cultures stored at pH 7.3 at this temperature. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Augmented very low frequency component of heart rate variability during obstructive sleep apnea.

After documenting the presence of obstructive sleep apnea syndrome (OSAS) through polysomnographic monitoring, we performed simultaneous ambulatory recordings of electrocardiogram, oronasal airflow, and pulse oximetry on 12 OSAS patients with normal autonomic nervous function for a period of 24 hours. The power spectrum of heart rate variability was investigated before and during treatments using dental appliances. Freuquency domain analysis showed that the very low frequency component of heart rate (0.008-0.04 Hz) was increased in OSAS patients and that a very low frequency peak appeared during episodes of obstructive sleep apnea. The increase in very low frequency identification was synchronized with episodes of absence of air exchange or hypoxemia (decreased arterial oxygen saturation) that occurred repeatedly at a cycle length of 25-120 seconds in our subjects. Frequency domain analysis of heart rate variability before and during prosthetic mandibular advancement treatment showed that only the very low frequency was significantly decreased during prosthetic mandibular advancement treatment, whereas the other frequencies, i.e. high, low, and ultralow frequency component values, showed no significant changes. Time domain analysis of heart rate variability before and during prosthetic mandibular advancement treatment showed no significant changes in any of these parameters. Frequency domain analysis of heart rate variability during nocturnal sleep, especially investigation of very low frequency and very low frequency peak, can be a noninvasive low-cost approach to diagnose and even better monitor subjects undergoing treatment at home, particularly considering that R-R intervals can be extracted from pulse oximetry and that analysis software programs are already commercially available.
A vital role of tubulin-tyrosine-ligase for neuronal organization

Tubulin is subject to a special cycle of detyrosination/tyrosination in which the C-terminal tyrosine of α-tubulin is cyclically removed by a carboxypeptidase and readded by a tubulin-tyrosine-ligase (TTL). This tyrosination cycle is conserved in evolution, yet its physiological importance is unknown. Here, we find that TTL suppression in mice causes perinatal death. A minor pool of tyrosinated (Tyr-)tubulin persists in TTL null tissues, being present mainly in dividing TTL null cells where it originates from tubulin synthesis, but it is lacking in postmitotic TTL null cells such as neurons, which is apparently deleterious because early death in TTL null mice is, at least in part, accounted for by a disorganization of neuronal networks, including a disruption of the cortico-thalamic loop. Correlatively, cultured TTL null neurons display morphogenetic anomalies including an accelerated and erratic time course of neurite outgrowth and a premature axonal differentiation. These anomalies may involve a mislocalization of CLIP170, which we find lacking in neurite extensions and growth cones of TTL null neurons. Our results demonstrate a vital role of TTL for neuronal organization and suggest a requirement of Tyr-tubulin for proper control of neurite extensions.
Induction of plasma protein secretion in a newly established human hepatoma cell line

To study the expression and the regulation of hepatocyte markers, we have undertaken to establish human hepatoma cell lines of various phenotypes. We now report the establishment of a new human hepatoma cell line, HA22T/VGH. This cell line has many of the properties of human hepatocellular carcinoma. Only 5 of 15 plasma proteins investigated were detected in the medium of a 10-day-old HA22T/VGH culture. However, when the HA22T/VGH cells and a clonal derivative, C5, were cultured in an aggregated form, all 15 plasma proteins were found in the culture medium. These results indicate that hepatoma cell lines with different phenotypes can be established, and they provide a good experimental framework to investigate differentiation of human hepatocytes.
Positive and Negative Symptoms and the Thematic Organisation of Schizophrenic Speech

Summary This study questions the prevailing view that schizophrenic delusions, hallucinations and incoherence of speech (positive symptoms) reflect loss of cognitive control and that flattening of affect and poverty of speech (negative symptoms) reflect restriction of cognitive processing. The prevailing view was examined by analysing the thematic organisation of speech produced by 18 patients describing pictures. Results showed that (a) positive and negative symptom schizophrenics did not differ in the control and restriction of thematic speech organisation; (b) speech disordered schizophrenics, positive as well as negative, showed cognitive restriction, by producing fewer inferential ideas than non-speech disordered schizophrenics. The wider implications of these results are discussed, particularly the implications of (b) for the notion of concreteness in schizophrenia.
The Role of Interpersonal Conflict as a Determinant of Firearm-Related Homicide–Suicides at Different Ages

Although firearm-related homicide–suicides and firearm-related suicides are tragic and catastrophic events, there is increasing evidence that the two events have different precipitants and that understanding these precipitants may help prevention efforts. We aimed to assess the role of interpersonal conflict (IPC) and recent crises in firearm-related homicide–suicides as compared with firearm-related suicides alone. We also assessed whether these differences were consistent across young and old perpetrators. Using an unmatched case-control study, we compared firearm-related homicide–suicides andsuicides alone from 2003 to 2011 in the National Violent Death Registry data to assess the risk associated with IPC and crisis. Survival analysis was performed to compare time-to-incident of homicide–suicide versus suicide only. We derived odds ratios (ORs) and 95% confidence intervals (95%CI) due to IPC and recent crisis from mixed logistic regression models. Stratified analysis by age on the effect of IPC and recent crisis, and type of incident was also performed. After adjusting for relevant covariates, homicide–suicides were more likely than suicide alone following IPC (OR = 20.6, 95%CI = [16.6, 25.7]) and recent crisis (OR = 14.5, 95%CI = [12.4, 16.9]). The risk of firearm homicide–suicide compared with suicide associated with IPC was twice greater among those >30 years compared with those ≤30 years (p-interaction = .033), and no differential by age associated with recent crisis (p-interaction = .64). IPC and recent crisis are risk factors for committing homicide–suicides compared with suicides alone, with the risk doubly greater among older than younger perpetrators.
Impact of prepregnant body mass index and maternal weight gain on the risk of pregnancy complications in Japanese women

Background. To analyze the association of pregnancy complications with prepregnant body mass index and weight gain during pregnancy in Japanese women. Methods. A retrospective cohort study was conducted with 21,718 Japanese women with a singleton pregnancy. Pregnant women were grouped by prepregnant body mass index and evaluated for association with pregnancy complications using multivariate logistic regression analysis. The women in each body mass index group were then divided into groups by weight gain during pregnancy using intervals of 0.05 kg/week to analyze the relationship between the weight gain and pregnancy complications by multivariate logistic regression association analysis. Results. In both nulliparous and parous women, the least pregnancy complications were found among women with medium prepregnant body mass indexes (18–23.9). Significant risks of pregnancy complications were associated with low (<18) and high (≥24) prepregnant body mass indexes, particularly high prepregnant body mass indexes. In nulliparous women, the optimal weight gain was 0.25–0.4 kg/week for low (<18) prepregnant body mass index, 0.20–0.30 kg/week for medium (18–23.9) prepregnant body mass index, and ≥0.05 kg/week for high (≥24) prepregnant body mass index. In parous women, the corresponding values were ≥0.20, 0.20–0.30, and 0.05–0.30 kg/week. Conclusions. Japanese women with prepregnant body mass indexes from 18 to 23.9 are least associated with pregnancy complications, although there is a broad range of prepregnant body mass indexes associated with few pregnancy complications. Optimal weight gain is roughly inversely related to prepregnant body mass index.