Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Inflammatory Cytokines and Interleukin-6 Expression /Gene Polymorphism in Chronic Periodontitis: Review of the Literature

Periodontitis is a chronic inflammatory condition of the periodontal tissues involving interactions between bacterial products, inflammatory mediators, and various cell populations. It is accepted that periodontitis is initiated by the dental plaque formation on the teeth surfaces. Dental plaque ingredients such as antigens, lipopolysaccharides, and other factors, initiate an inflammatory and immune response, leading to the activation of host cells which results in the release of inflammatory mediators such as cytokines, chemokines, arachidonic acid metabolites and proteolytic enzymes which contribute to tissue destruction and bone resorption. Recent research regarding the pathogenesis of periodontal diseases has clarified the involvement of various cytokines in the biological activities that are implicated in its pathogenesis. Cytokines play crucial roles in the maintenance of tissue homeostasis, whereas excessive or continuous cytokines production in inflammatory periodontal tissues is responsible for the progress of periodontitis and periodontal tissue destruction. Inflammatory cytokines-such as IL-6, IL-13, and IL-8 are present in the damaged periodontal tissues, and their production is involved in chronic leukocyte recruitment, tissue and bone destruction. It is possible that cytokine production and expression may result to diagnose an individual's periodontal disease status or susceptibility to the disease. Moreover, despite the contradictory suggestions, it has been proposed that T-cell subsets Thl and Th2 with different cytokine profiles play crucial roles in the immunopathogenesis of periodontal disease. Chronic periodontitis is suggested to be related to gene variations whereas; genetic variations which are observed in cytokines may affect periodontitis susceptibility. The aim of the current review was to present the role of inflammatory cytokines and Interleukin-6 expression and its gene polymorphism in chronic periodontitis pathogenesis. * Corresponding author: Dr. Nikolaos Andreas Chrysanthakopoulos, University of Athens, 35, Zaimi Street, PC 26 223, Patra, Greece, Tel. /Fax: 0030-2610-225288; E-mail: nikolaos_c@hotmail.com, nchrysant@med.uoa. gr Received: 12 June 2020 Accepted: 04 July 2020 Published: 08 July 2020 Citation: Chrysanthakopoulos NA. The Role of Inflammatory Cytokines and Interleukin-6 Expression /Gene Polymorphism in Chronic Periodontitis: Review of the Literature. J Clin Case Rep Med Res 2020;1:04 Copyright: Chrysanthakopoulos NA. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license Journal of Clinical Case Reports and Medical Research Review Article Article Id: JCCRMR-20-04
A Study On The Relationship Between Corporate Reputation And Customer Loyalty In Hotels

In recent years, the concept of reputation has proven to be one of the major innovative trends in corporate management. Both scholars and the popular press have become increasingly interested in the management of corporate reputation. Corporate reputation is the result of a signaling activity based on available information about a firm’s actions. Reputation is also a yardstick of the firm’s relative standing routinely used by both internal and external stakeholders when making firm-related decisions (Dentchev and Heene, 2004: 56). Several empirical studies also confirm the positive relationship between good reputation and competitive advantage. The purpose of this study is to determine the relationship between the corporate reputation and customer loyalty to the company in tourism industry. In this context, this study conducted in an active tourism firm’s customers in Turkey, finds that there are significant relations between the five dimensions of the corporate reputation and the loyalty of the customers.
ANALYSIS OF CONSUMER PREFERENCE AND USAGE PATTERN OF BRANDED FRESH MILK IN NIZWA, SULTANATE OF OMAN

Dr. Renjith Kumar. R Lecturer, Business Studies Department, Nizwa College of Technology, Sultanate of Oman Email: cvrrkachu@gmail.com Aisha Hamood Ali Al-Shukaili Email: 26J1325@nct.edu. om Hajar Masoud Ali Almanyia Email: 21J1363@nct.edu. om Noof Saleh Ghareb Al-Shariqi Email: 21J13237@nct.edu. om Zahra Mohammed Abdullah Al-Khatri Email: 21J13108@nct.edu. om B.Tech in Marketing, Nizwa College of Technology, Sultanate of Oman
Indicate and Analyze the Reviews for Efficient Product Marketing on E-Commerce

: Until making an educated buying decision online reviews have become a significant source of information for consumers. Early evaluation of a product appears to have a major effect on subsequent sales of the product. In this paper, through their posted reviews on two real-world major E-commerce sites, we take the initiative to research the behavioral characteristics of early reviewers. In particular, we divide the lifetime of the commodity into three consecutive phases, namely early, majority and laggards. A user who initially posted a review is considered an early reviewer. Based on their rating habits, the helpfulness ratings earned from others and the association of their feedback with product popularity, we quantitatively classify early reviewers. We proposed here, the product review content is taken into account in terms of a contribution isn’t merely a sales message to promote a product you love; instead, a balanced product review will indicate the execs and cons of a given product or service, serving your readers to find out whether or not it's the right one for them.
Detection of metastable He2* molecules in helium plasma

Metastable He2* molecules, ubiquitous in helium systems, consist of a metastable He* (2^3S1) and a ground-state He atoms. Their detection through the optical transition a^3Σu^+(ν=0) has been performed in He plasma (P=8-267 mbar) with a tunable cw laser at 465 nm, based on the sum frequency generation of 923 and 937 nm in the PP-KTP crystal. The laser has been characterized for its wavelength tuning and efficiency of nonlinear conversion. Absorption rates provide direct access to He2* number densities, based on quantitative spectroscopic data obtained for the probed rotational branches. Studies mainly involve 3He2* but its isotopologues are also studied in isotopic mixtures and pure 4He gas. He2*absorption spectra yield rotational temperatures close to the gas temperatures. In addition to the spin-statistics-driven line intensities alternation, an alternation of 3He2* line shapes occurs indicative of the underlying structure of the rotational states. Time evolution of absorption signals has been recorded in discharge afterglow providing quantitative information about dynamics and relative abundances of the metastable species. The He∗ density varies for strong laser excitation of He* at 1083 nm, as formation rate from the 23P state is 100-times higher. Simultaneous absorption measurements on atoms and molecules during the metastability exchange optical pumping (MEOP) experiments has been performed to study the potential contribution of He2* to the laser-enhanced 3He nuclear relaxation observed in MEOP. Preliminary results have shown expected increase in molecular density that is so far mild in comparison with the spectacular enhancement of 3He nuclear relaxation rate.
2-Cl-C.OXT-A stimulates contraction through the suppression of phosphodiesterase activity in human induced pluripotent stem cell-derived cardiac organoids

Background 2-Cl-C.OXT-A (COA-Cl) is a novel synthesized adenosine analog that activates S1P1 receptor (S1P1R) and combines with adenosine A1 receptor (A1R) in G proteins and was shown to enhance angiogenesis and improve the brain function in rat stroke models. However, the role of COA-Cl in hearts remains unclear. COA-Cl, which has a similar structure to xanthine derivatives, has the potential to suppress phosphodiesterase (PDE), which is an important factor involved in the beating of heart muscle. Methods and results Cardiac organoids with fibroblasts, human induced pluripotent stem cell-derived cardiac myocytes (hiPSC-CMs), and hiPSC-derived endothelial cells (hiPSC-ECs) were cultured until they started beating. The beating and contraction of organoids were observed before and after the application of COA-Cl. COA-Cl significantly increased the beating rate and fractional area change in organoids. To elucidate the mechanism underlying these effects of COA-Cl on cardiac myocytes, pure hiPSC-CM spheroids were evaluated in the presence/absence of Suramin (antagonist of A1R). The effects of COA-Cl, SEW2871 (direct stimulator of S1P1R), two positive inotropes (Isoproterenol [ISO] and Forskolin [FSK]), and negative inotrope (Propranolol [PRP]) on spheroids were assessed based on the beating rates and cAMP levels. COA-Cl stimulated the beating rates about 1.5-fold compared with ISO and FSK, while PRP suppressed the beating rate. However, no marked changes were observed with SEW2871. COA-Cl, ISO, and FSK increased the cAMP level. In contrast, the level of cAMP did not change with PRP or SEW2871 treatment. The results were the same in the presence of Suramin as absence. Furthermore, an enzyme analysis showed that COA-Cl suppressed the PDE activity by half. Conclusions COA-Cl, which has neovascularization effects, suppressed PDE and increased the contraction of cardiac organoids, independent of S1P1R and A1R. These findings suggest that COA-Cl may be useful as an inotropic agent for promoting angiogenesis in the future.
Logistics service quality impact on customer satisfaction and loyalty

Today, logistics research is focused on examining of logistics companies’ abilities to give service of high quality and, according to the service given, make and retain satisfied customers. Customer loyalty development is often seen as unavoidable problem in management of every company that is looking for sustainable and long-lasting presence on desired market. It is the analysis of quality, customer degree of satisfaction and loyalty in the context of logistics service this paper is focused on. It’s assumed that there is a positive relation between the logistics service quality, satisfaction and loyalty of customer. Having analyzed different approaches that can be found in literature, conceptual model is developed with an aim to identify factors that have an impact on loyalty of logistics services customer. Special attention is given to attributes of logistics service quality. On the basis of the developed model, empirical researches are conducted on Serbia’s market the results of which are, together with critical analysis, presented in this paper.
Proline, A Peculiar Amino Acid with Astucious Functions in Development and Salt Tolerance Process in Plants

Proline is known to play diverse functions in plants. Some aspects of its biological functions are still unclear. This review highlights some cases in the proline, structure, metabolism, functions in development and also its involvement in salt tolerance process in planta. Indeed, we report the clever roles of proline in cellular homeostasis, including redox balance and their implication as effector during some causal enzymological and physiological processes. Furthermore, the proline functions under abiotic stresses are not yet completely understood. The engineering of proline metabolism could lead to new opportunities to improve plant tolerance against environmental stresses, especially salinity. Eventually, we note that the purpose through this review is to provide a rich, concise and mostly cohesive source on proline, considered as a platform and an anchor between several disciplines and biological functions. We also provide insight on some important research gaps that need to be filled to advance our scientific understanding in this area of research on proline in soil-plant systems.
Antibacterial activity of fosetyl‐Al, ethyl‐phosphite and phosphite against Pseudomonas syringae on plant surfaces and in vitro

Fosetyl-Al (the aluminium salt of ethyl-phosphite) is an acid product used to fight oomycete diseases and sometimes used against bacterial diseases, but its antibacterial mode of action is largely unknown. Therefore, the direct effects of fosetylAl and neutralized fosetyl-Al on the colonization of leaf surfaces by Pseudomonas syringae were compared. Control of colonization was highest and almost complete in acidic conditions (99.7%), showing the importance of acidity for maximal antibacterial efficacy on plant surfaces. However, the high inhibition obtained with neutralized fosetyl-Al (88.9%) suggested another direct effect. Therefore, it was investigated in vitro whether ethyl-phosphite has antibacterial activity, possibly related to its phosphite content. Inhibition of P. syringae growth by ethyl-phosphite was observed and influenced by the carbon source and by phosphate. Growth inhibition reached 83.1% in unshaken conditions in a phosphatedepleted glucose medium. Phosphite drastically increased the effects and induced up to 99.7% growth inhibition. Mass spectrometric analysis indicated that P. syringae hydrolysed ethyl-phosphite to phosphite using a cell-linked phosphatase activity. Specific phosphite toxicity was observed in phosphate-sufficient succinate media and phosphite-induced phosphorus starvation was observed in phosphate-depleted glucose media, indicating that ethyl-phosphite and phosphite have direct environmental impacts on bacteria. Phosphite toxicity for P. syringae probably occurred in the phyllosphere. The study indicates the potential and limitations of fosetyl-Al as a direct antibacterial product and helps in understanding the fosetyl-Al control of flower bud blast in pear. It raises the prospect of using phosphite in plant bacterial disease control.
The Effect of Corporate Social Responsibility Disclosure and Intellectual Capital Elements toward Corporate Value

The purpose of this study is to determine the effect of corporate social responsibility disclosure and intellectual capital elements toward corporate value, with the financial performance as intervening variable. The populations of this study are manufacturing companies listed by the Indonesia Stock Exchange (IDX) within the period of 2015-2017. Data were collected by using purposive sampling method. Based on the mentioned criteria, 53 companies were selected as the samples of this study with 159 data. The analysis data method was using descriptive statistics and multiple regression analysis with Eviews software 9 versions. The finding shows that that (1) corporate social responsibility disclosure has a negative effect to financial performance; (2) Intellectual capital elements (VACA, VAHU and STVA) have positive significant effect to financial performance. (3) Corporate social responsibility disclosure has positive significant effect to corporate value. (4) Intellectual capital element (VACA, VAHU) has no effect to corporate value while intellectual capital element (STVA) has negative effect to corporate value. (5) Financial performance has positive significant to corporate value. (6) The financial performance has mediated the relationship between corporate social responsibility disclosure and corporate value. (7) The financial performance has mediated the relationship between intellectual capital elements (VACA, STVA) and corporate value but VAHU has not mediated.
The Generalized Composite Commodity Theorem: Aggregation of Grocery Items at Firm Level Preliminary and Incomplete: Please Do Not Quote or Cite

The large number of products and prices in multi-product rms causes great di¢ culty in analyzing consumers choice among them. Prices of all products in each rm play some roles in consumersdecision-making process. However, accounting for all of them would be very di¢ cult of not impossible. According to the Generalized Composite Commodity Theorem (GCCT) developed by Lewbel (1996), it is possible to obtain valid aggregation of commodities if some certain conditions are satis ed. A valid aggregation would maintain the four conditions of rational demand systeme.g. adding up, homogeneity, slutsky symmetry and negative semi-de niteness. Using data from the UK supermarket industry, this paper shows that it is valid to aggregate grocery items by their supermarket rms.                     I am grateful to Howard Smith and Takamitsu Kurita for their guidance and support. I am also grateful to Arthur Lewbel for very useful discussions and suggestions. For nancial support, I am grateful to the UKs Milk Development Council who made obtaining this data set possible. Any remaining errors are my own. y Department of Economics, University of Oxford. Email: wanwiphang.manachotphong @economics.ox. ac.uk.
Graph Convolutional Network

: In aspect-based sentiment classification, the attention mechanism is often combined in recurrent neural network or convolutional neural network to obtain the importance of different words. However, such kind of methods fail to capture long-range syntactic relations that are obscure from the surface form, which would be beneficial to identify sentiment features directly related to the aspect target. In this paper, we propose a novel model named MemGCN to explicitly utilize the dependency relationship among words. Firstly, we employ the memory network to obtain the context-aware memory representation. After that, we apply graph convolutional network over the dependency tree to propagate sentiment features directly from the syntactic context of an aspect target. Finally, attention mechanism is used to fuse memory and syntactic information. We conduct extensive experiments on the SemEval 2014 and Twitter dataset, and results demonstrate that our model outperforms baseline methods.
The extrinsic plural marker in Korean

This paper presents a series of experiments designed to shed light on some aspects of the use and interpretation of so-called ‘extrinsic -tul’ by child and adult native speakers of Korean. Our findings indicate that this morpheme occurs far less frequently than the intrinsic plural marker in both speech and writing, and that it is most likely to appear on an adverb. An experiment designed to confirm its oft-claimed status as a distributive marker reveals that whereas adults systematically interpret it in this way, children under the age of 8 rarely do, even when appropriate contextual support is provided.
Towards High Performance Mobility Simulations

E ﬃ cient public transportation plays a key role in addressing crucial societal challenges such as urban planning, pollution, or energy consumption. To understand how transportation systems might evolve and determine the impact of new technologies and planning decisions, tra ﬃ c simulations are used to explore di ﬀ erent scenarios and help with the planning process. Existing tools, however, su ﬀ er from scalability and performance problems when it comes to simulating country-wide scenarios with millions of moving agents, scenarios that are needed to understand how complex transportation networks behave. In collaboration with the Swiss Railway Services (SBB) and IVT (ETH), the Systems Group at ETH is developing a high performance and scalable tra ﬃ c simulation platform capable of, initially, covering the entire population and transportation network of Switzerland. With current tools, such scenarios are projected to take months of computing time when running on a powerful multi-core server. By redesigning MATSim’s simulation engine for the use of highly e ﬃ cient data structures and algorithms, we have been improving its performance, allowing us to pursue our end goal of simulating a Swiss-scale scenario. Further performance gains are expected as we include improvements on convergence rates, the replanning stages of the simulation, and enable scalability across clusters of machines.
Annotation and Sentiment Analysis for Myanmar News

This paper presents a corpus of Myanmar News and its metadata, annotated with sentiment polarity. It contains 100 news from Myanmar media websites such as news-eleven.com, 7daydaily.com and popularmyanmar.com. This news dataset is of at most value as all the annotation is done manually and this makes it a very rich dataset for training purposes. In this work, we describe the creation and annotation process, content, and the possible uses of the dataset. As an experiment, we have built a basic classification system to identify the emotion polarity of the news. N-gram feature selection algorithm is used in this system to select the most relevant features from training dataset. In Experiment, we classify the News by using well-known Naïve Bayes classifier.
Solution Of Order Batching Problem With Association Rules And Genetic Algorithm: A Case Study In Pharmacy Warehouse

Bu calismada, bir ecza deposunun gunluk siparis toplama stratejisi incelenmis ve uygun bir yaklasim gelistirilmistir. Urunlerin ve siparislerin hacimsel olarak kucuk oldugu, toplayici kapasitesinin goreceli olarak buyuk oldugu depolar icin uygun olan, siparis yiginlama stratejisi kullanilmistir. Gunluk siparisler, siparisler arasi iliskiyi en buyukleyen bir matematiksel modelin yardimiyla siparis yiginlarina ayrilmis. Birden cok siparisin bir araya gelmesiyle olusan yiginlar icerisinde benzer urunleri iceren siparisler bulundugu icin toplama sirasinda ki kayip zaman ve mesafeden tasarruf saglanacaktir. Matematiksel modelin kesin cozumunun zaman almasi nedeniyle genetik algoritma kullanilarak sonuc uretilmistir. Farkli toplama stratejileri sonucunda kat edilen toplam mesafe benzetim yardimiyla hesaplanarak, istatistiki olarak sonuclarin guvenilirligi ve performanslari sonuc bolumunde tartisilmistir.
PKS2: A link between phototropin signalling and auxin transport - a study on how plants sense and respond to light.

The blue light photoreceptors phototropins (phot1 and phot2 in Arabidopsis thaliana (L.)) carry out various light responses of great adaptive value that optimize plant growth. These processes include phototropism (the bending of an organ induced by unequal light distribution), chloroplast movements, stomatal opening, leaf flattening and solar tracking. The biochemical pathways controlling these important blue light responses are just starting to be elucidated. The PHYTOCHROME KINASE SUBSTRATE (PKS1-4) proteins - the subject of this research - have recently been identified as novel phototropism signalling components. PKS1 (the founding member of this family) interacts in a same complex in vivo with phot1 and the important phot1 signalling element NON-PHOTOTROPIC HYPOCOTYL 3 (NPH3). This suggested that the PKS may act as early components of phot signalling. This work further investigates the role of this protein family during phototropin signalling Genetic experiments clearly showed that the PKS do not control chloroplast movements or stomatal opening. However, PKS2 plays a critical role with NPH3 during leaf flattening and solar tracking. Epistasis data indicated that both proteins act in phot1 and phot2 pathways, which is consistent with their in vivo interaction with both phototropins. Because phototropism, leaf flattening and solar tracking are developmental processes regulated by the hormone auxin, the role of PKS2 and NPH3 during auxin homeostasis was also investigated. Interestingly, PKS2 loss-of-function restores leaf flattening in the auxin transporter mutant aux1. Moreover, PKS2 and NPH3 are found in a same complex with AUX1 in vivo. Taken together, these results suggest that PKS2 may act with NPH3 as a connecting point between phot signalling and auxin transport. Further experiments were performed to explore the molecular mode of action of PKS2 and NPH3 in this process. The significance of these results is discussed.