Miracle-dz/UniFAR-FTUs huggingface dataset:
Adverse Events in the Netherlands Vaccination Programme : Reports in 2010 and Review 1994-2010

In 2010, 800,000 children received one or more vaccines on 1.3 million dates, with more than 7 million vaccine components. There is always some chance of adverse reactions but these are usually not severe, though sometimes frightening. This year, RIVM received 1380 reports of adverse events following immunisation (AEFI). This is 16% less than in 2009 when 2 vaccination campaigns raised considerable adverse publicity with subsequent increase in reports. Data show that the benefit of the vaccination programme outweighs the risk of adverse reactions by far. Safety surveillance: necessary part of the vaccination programme. Enhanced safety surveillance has been an integral part of the vaccination programme since 1962. Annual reports have been published since 1983, following independent reevaluation. The surveillance system of the Netherlands enjoys very high reporting rates and is highly sensitive for signals. It allows individual follow-up because of name-based reporting. In this last year of safety surveillance in this setting, we present an overview of results since 1994. This brings some new insights. Careful reporting and validation system. All reports were validated and complemented, preferably also with eyewitness accounts (92%). Final assessment followed according to case definitions and causality criteria. The embedding of the safety surveillance in the telephone consultation service has contributed to the quality of the reports. Reported adverse events. In 2010, 78% of reports (1082) had possible causal relation with the vaccination. These concerned major adverse reactions in 48% (523), including very high fever (>40.5 °C), persistent screaming, collapse, discoloured legs, febrile convulsions or atypical attacks with chills, myoclonics or hyper/hypo-tonicity. Altogether 22% (296) of reports were chance occurrences. Reported severe infections and epilepsy had no causal relation with the vaccinations. In addition, none of the 5 reports on death was related to vaccination. An independent expert committee has reassessed these severe adverse events.
Heparins: A Shift of Paradigm

Heparins inhibit the thrombin forming capacity of plasma, i. e. , the endogenous thrombin potential (ETP), by their anti-thrombin (aIIa) activity, the anti-factor Xa (aXa) activity is of minimal importance. This holds for both unfractionated heparin (UFH) and low molecular weight heparin (LMWH) at aXa/aIIa ratios < 25. Clinical experience and epidemiological evidence show a direct relationship between the ETP and the risk of thrombosis and bleeding. Consequently, the therapeutic potency of a heparin is determined by its aIIa activity, i.e., the concentration of a domain in which 12 sugar flank the high affinity antithrombin-binding pentasaccharide (HA5) at one side. The response of individual plasmas to a fixed dose of any heparin is highly variable. This suggests that individualization of heparin dosage, on basis of the ETP, might reduce bleeding or re-thrombosis. There exist simple laboratory methods for both the ETP and the concentration of the active domain. These methods can be used both for unequivocally characterization of a heparin preparation and for controlling heparin therapy and allow arbitrary units relative to a standard to be abandoned. These tests are as robust as any hematological routine test but not yet routinely available, which severely encumbers progress in the field.
SS-31 Peptide Reverses the Mitochondrial Fragmentation Present in Fibroblasts From Patients With DCMA, a Mitochondrial Cardiomyopathy

We used patient dermal fibroblasts to characterize the mitochondrial abnormalities associated with the dilated cardiomyopathy with ataxia syndrome (DCMA) and to study the effect of the mitochondrially-targeted peptide SS-31 as a potential novel therapeutic. DCMA is a rare and understudied autosomal recessive disorder thought to be related to Barth syndrome but caused by mutations in DNAJC19, a protein of unknown function localized to the mitochondria. The clinical disease is characterized by 3-methylglutaconic aciduria, dilated cardiomyopathy, abnormal neurological development, and other heterogeneous features. Until recently no effective therapies had been identified and affected patients frequently died in early childhood from intractable heart failure. Skin fibroblasts from four pediatric patients with DCMA were used to establish parameters of mitochondrial dysfunction. Mitochondrial structure, reactive oxygen species (ROS) production, cardiolipin composition, and gene expression were evaluated. Immunocytochemistry with semi-automated quantification of mitochondrial structural metrics and transmission electron microscopy demonstrated mitochondria to be highly fragmented in DCMA fibroblasts compared to healthy control cells. Live-cell imaging demonstrated significantly increased ROS production in patient cells. These abnormalities were reversed by treating DCMA fibroblasts with SS-31, a synthetic peptide that localizes to the inner mitochondrial membrane. Levels of cardiolipin were not significantly different between control and DCMA cells and were unaffected by SS-31 treatment. Our results demonstrate the abnormal mitochondria in fibroblasts from patients with DCMA and suggest that SS-31 may represent a potential therapy for this devastating disease.
Brain Connectivity Based Prediction of Alzheimer’s Disease in Patients With Mild Cognitive Impairment Based on Multi-Modal Images

Structural and metabolic connectivity are advanced features that facilitate the diagnosis of patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Connectivity from a single imaging modality, however, did not show evident discriminative value in predicting MCI-to-AD conversion, possibly because the inter-modal information was not considered when quantifying the relationship between brain regions. Here we introduce a novel approach that extracts connectivity based on both structural and metabolic information to improve AD early diagnosis. Principal component analysis was performed on each imaging modality to extract the key discriminative patterns of each brain region in an independent auxiliary domain composed of AD and normal control (NC) subjects, which were then used to project the two subtypes of MCI to the low-dimensional space. The connectivity between each target brain region and all other regions was quantified via a multi-task regression model using the projected data. The prediction performance was evaluated in 75 stable MCI (sMCI) patients and 51 progressive MCI (pMCI) patients who converted to AD within 3 years. We achieved 79.37% accuracy, with 74.51% sensitivity and 82.67% specificity, in predicting MCI-to-AD progression, superior to other existing algorithms using either structural and metabolic connectivities alone or a combination thereof. Our results demonstrate the effectiveness of multi-modal connectivity, serving as robust biomarker for early AD diagnosis.
Interactive Space Creation through Play

In this paper we report on recent developments in the use of simulation as an aspect of design decision support for architecture and planning. This research is based on ARTHUR (Augmented Round Table for Architecture and Urban Planning). Although real time simulation has been incorporated in design support systems, little attention has been given to the simulation of pedestrian movement in collaborative AR based systems. Here we report on user evaluation tests of the ARTHUR system, which are focused on the effect of real time pedestrian simulation on the way pairs of designers work together. These tests suggest that the integration of simulated pedestrian movement on the design table plays a critical role in exploring possible design solutions and encourages different and new ways of thinking about design problems. Donald Schon’s concept of the reflection-in-action provide a useful framework for interpreting these results.
A New Uncertainty Budgeting-Based Method for Robust Analog/Mixed-Signal Design

This article proposes a novel methodology for robust analog/mixed-signal IC design by introducing a notion of budget of uncertainty. This method employs a new conic uncertainty model to capture process variability and describes variability-affected circuit design as a set-based robust optimization problem. For a prespecified yield requirement, the proposed method conducts uncertainty budgeting by associating performance yield with the size of uncertainty set for process variations. Hence the uncertainty budgeting problem can be further translated into a tractable robust optimization problem. Compared with the existing robust design flow based on ellipsoid model, this method is able to produce more reliable design solutions by allowing varying size of conic uncertainty set at different design points. In addition, the proposed method addresses the limitation that the size of the ellipsoid model is calculated solely relying on the distribution of process parameters, while neglecting the dependence of circuit performance upon these design parameters. The proposed robust design framework has been verified on various analog/mixed-signal circuits to demonstrate its efficiency against the ellipsoid model. Up to 24% reduction of design cost has been achieved by using the uncertainty budgeting-based method.
Ranula in the Arab Medical Heritage

Ibn Sina said in his book The Canunn “the frog is like a semi solid gland beneath the tongue with a color similar to that formed by the tongue surface and the veins which is similar to frog shape and its cause is a dense viscose humidity (5). Ranula Treatment The treatment for Thabet is by medicaments, which is to massage it with Banoshader (which is a kind of salt which gets out a solid metal) (6), and Gall oak (a tree similar to cypress from the Coniferae). If it is cooked with vinegar and drunk it will tighten the gingiva and prevent its wearing (7), If this was sufficient then it’s ok otherwise the hot drug prescribed for bloody gingival should be taken as rinse with vinegar and salt (8).
Entwicklung einer physiotherapeutischen Klassifikation von Schulterschmerzen

Zusammenfassung Ärztliche Diagnosen für Schulterschmerzen basieren auf einer pathoanatomischen Terminologie und können nur beschränkt physiotherapeutische Interventionen leiten. Diagnostische Bezeichnungen sollen zu einer spezifischen Behandlung führen. Wird der Fokus auf die Beschreibung der menschlichen Bewegung geändert, ergibt sich ein pathokinesiologisches Modell. Die Identifikation charakteristischer Bewegungsbeeinträchtigungen könnte sich als physiotherapeutisches Klassifikationsschema eignen. Das Ziel der Studie bestand darin, ein spezifisch physiotherapeutisches Klassifikationsschema zu entwickeln, das den Bedürfnissen und Kompetenzrahmen von Physiotherapeuten gerecht wird. Dazu wurden in einem 4-Runden-Delphi-Design deutschsprachige Physiotherapeuten mit Expertise bei der Behandlung von Schulterschmerzen zu einem entsprechenden möglichen Klassifizierungsmodell befragt. Basierend auf den Ergebnissen wurde ein physiotherapeutisches Klassifikationsmodell entwickelt. Diese Klassifizierung führt weg von der alleinigen Identifizierung einer schmerzhaften Struktur hin zu einer bewegungsbezogenen Diagnostik und leitet somit direkt die Behandlung.
The influence of first language on referential expressions of Japanese language learners: A focus on narrative story by native Chinese and Korean speakers

Abstract The present study examines how Japanese language learners use referential expressions in discourse, especially topicalized or non-topicalized subjects, in addition to whether the first language of a Japanese language learner influences the choice of referential expressions. The text of narrative stories, written in both the subject’s first language and second language (i.e. Japanese) by native Chinese speakers and native Korean speakers, as well as text written by Japanese native speakers, were analyzed. As a result, the first language influence and common difficulties were observed in the use of referential expressions by Japanese language learners. Using referential expressions is not simply a matter of negative or positive transfer.
Effect of Donor Selection on the Early Outcome of Heart Transplant Recipients

for excluding potential organ donors. Early criteria were fairly strict, but with the increasing demand for organs, donation from an expanded donor pool has loosened restrictions considerably. With several years of data, it is clear that the total number of heart transplants is declining. The average donor age appears to have reached a plateau and may even be declining. In 1994, the number of heart transplants peaked at 4466, and in 1999 this number had dropped to 2733. Optimal management of multiorgan donors is critical to the successful outcome of transplantation. The optimal management of hemodynamic and respiratory status is essential to maximize the yield of suitable thoracic donor organs. The aim of this study was to evaluate how the expansion of the donor pool has affected heart transplant outcomes and to identify possible risks associated with donor variables. We further attempted to evaluate the significant role donor selection plays in heart transplant outcomes.
Immunosuppressant Strategies for Intestinal Transplantation: A Review of a Tolerogenic Regimen

According to the International Intestinal Registry, 989 intestinal transplantations have been performed in 923 patients from 1986 through May 2003 at 61 centers around the world. The number of intestinal transplantations had steadily increased each year since 1986, but has recently plateaued to about 100 cases per year. The majority of recipients are pediatric patients (61%) and male (54%). The vast majority of grafts (97%) are from cadaveric donors, with living donor grafts accounting for only 3% (n=32). Children more commonly require a composite liver-intestine graft because of liver failure from total parenteral nutrition (TPN), their primary source of nutrition. The most common indications for intestinal transplantation in children are gastroschisis (21%), volvulus (17%), dysmotility (16%), necrotizing enterocolitis (12%), intestinal atresia (8%), and microvillus inclusion disease (6%). In adults, ischemia (23%), Crohn disease (14%), gastrointestinal neoplasm (16%), and trauma (10%) are the leading indications for intestinal transplantation. Retransplantation has been performed in 8% of pediatric recipients and 6% of adult recipients. As of May 2003, there were 484 recipients (52%) worldwide surviving intestinal transplantation. Sepsis has been the most common cause of death (49%), followed by rejection (11%), technical complications (9%), lymphoma (6%), and respiratory failure (6%). Survival has steadily improved since 1990 and is reported to be influenced by several factors. The era in which the patient received an intestinal transplant is important because graft survival has improved significantly over time (Figure 1A). The size of the transplant center significantly contributes to survival, with improved patient and graft survival reported at centers performing more than 10 intestinal transplantations (Figure 1B), reflecting the importance of the learning curve for this complex procedure. Other factors influencing surImmunosuppressant strategies for intestinal transplantation: a review of a tolerogenic regimen
Cryptanalysis of An Improved Predicate Encryption Scheme from LWE

Predicate encryption scheme is a paradigm which provides ﬁne-grained access control and has attractive applications. In 2017, Brakerski, Tsabary, Vaikuntanathan, and Wee (TCC 2017) proposed a new LWE based predicate encryption scheme in order to overcome drawbacks in the scheme proposed by Gorbunov, Vaikuntanathan and Wee (CRYPTO 2015). In this paper, We analyze this scheme and provide two practical attacks to show that the scheme (TCC 2017) is insecure under the full attribute hiding security model. These two attacks mainly exploit several homomorphic and linear properties in the construction. This illustrates that in order to construct full attribute hiding secure predicate encryption scheme these weak properties must be bypassed.
Influence of Specimen Molding Technique on Fatigue Properties of a Bone Cement

Fatigue failure of the acrylic cement mantle is one of the most common causes of aseptic loosening in cemented femoral prostheses. Cement fatigue properties can be assessed by mechanical in vitro tests, usually performed on properly shaped specimens from standard molds, following a controlled procedure. On the contrary, in the operating theatre the cement mantle is produced in the medullary channel after stem insertion by the surgeon. It is arguable whether the cement properties obtained from the in vitro tests reflect the actual fatigue properties of the cement mantle, as a less controlled procedure can create more defects in the cement. To evaluate the influence of cement preparation, molded specimens for fatigue tests were produced by three different methods. Specimens were molded, using hand-mixed cement, into a standard mold or into a purposely designed device, simulating stem insertion in the medullary channel. Two different specimens were molded with this device, the cement manually or syringe inserted. Fatigue tests were carried out with a sinusoidal uniaxial zero-tension load (15 MPa) and cycle numbers at failure recorded for the three different groups of specimens. The results showed that, in the case of specimens properly manufactured (using a syringe) the fatigue strength reaches values similar to those of standard molded specimens, but it significantly decreases if cement is not inserted according to proper surgical procedures. Therefore, in the operating theatre it is recommended that the correct and complete procedure is followed to limit the risk of early fatigue failure of the mantle.
ZebraTutor: Explaining How to Solve Logic Grid Puzzles

In this demonstration, we present ZebraTutor, an end-to-end solution for solving logic grid puzzles (also known as Zebra puzzles) and for explaining, in a humanunderstandable way, how this solution can be obtained from the clues. ZebraTutor3 starts from a plain English language representation of the clues and a list of all the entities present in the puzzle. It then applies NLP techniques to build a puzzle-specific lexicon. This lexicon is fed into a type-aware variant of the semantical framework of Blackburn and Bos ([1, 2]), which translates the clues into discourse representation theory. This logic is further transformed to a specification in the IDP language [4], an extension of first-order logic. It then uses this formal representation of the clues both to solve the puzzle and to explain how to a user can find this solution. The focus of our explanation is on simplicity: in generating explanations and choosing the order in which the reasoning steps are explained, we chose to order by an estimate of mental effort required to follow the reasoning step. Each reasoning step is visualised as the clue(s) involved and the resulting changes on the grid. When solving such puzzles, it can either be used for explaining how to obtain an entire solution, or for providing help to users who are stuck during the solving process. Indeed, our explanation method will, given a partial solution, find the easiest next derivation to make.
Organ Scarcity and the Psychological Pre—Heart Transplant Evaluation: A Simulation Study Using Community Residents

empirically proven treatment for end-stage heart disease. According to the International Registry for Heart and Lung Transplantation, more than 60000 heart transplants have been performed worldwide. Medical improvements in heart transplantation have yielded approximate 1-year survival rates of 80%, a 3-year survival rate of 78%, and a 10-year rate of 50%, making it a desirable treatment option for end-stage heart disease. Transplant data provided by the United Network for Organ Sharing reported that 3517 individuals were actively waiting for a donor heart in 2004. Of greater concern, in 2003, only 1978 donor hearts became available for transplantation, resulting in a significant organ shortage. Although research examining medical outcomes in heart transplantation has progressed, there are few studies examining the impact of organ scarcity on the transplant candidate evaluation process. The psychological pretransplant assessment is an integral component of the candidate evaluation process, assisting healthcare teams with forecasting the potential benefit of transplantation for a particular individual. Although pretransplant assessments vary across transplant centers, mental health professionals have been reported to use multiple sources of information to perform a comprehensive psychological pretransplant evaluation. According to Levenson and Olbrisch, clinical interviews and psychological testing were used at 67.9% and 24% of transplant centers, respectively. With regard to the administration of psychological testing, Organ scarcity and the psychological pre–heart transplant evaluation: a simulation study using community residents
Overhead Reduction of NR type II CSI for NR Release 16

In Release 15, new radio (NR) type II channel state information (CSI) feedback is promising significant performance gain over legacy long term evolution (LTE) codebooks, with more than 30% throughput enhancement in some cases. However, this gain comes at the expense of a significant increase in uplink (UL) overhead. That is why in Release 16 overhead reduction of existing Type II CSI is studied. In this work, we present results for overhead reduction of type II CSI using frequency domain compression. We also compare the performance against a simple extension of type II CSI that uses frequency domain interpolation.
Energy scheduling mechanism for intelligent terminal with simultaneous wireless information and power transfer

Wireless energy harvesting not only can extend the battery life of the device but also can solve the problem of energy shortage. In this paper, we first consider a point-to-point wireless transmission of low-power intelligent terminal equipment by the base station (BS) and model the problem as maximizing the total energy received by the user in a random fading channel over a period of time. Then, we comprehensively investigate how to control the transmit power for energy scheduling with Simultaneous Wireless Information and Power Transfer (SWIPT). Meanwhile, we describe the problem as a Markov Decision Process (MDP) and propose an optimal power allocation strategy. At last, we verify the simulation of the energy transmission efficiency with the optimal power transmission strategy. The simulation results show that the proposed optimal power transmission strategy outperforms the existing scheme in terms of energy transmission efficiency.