Miracle-dz/UniFAR-FTUs huggingface dataset:
Accuracy of finite element model-based multi-organ deformable image registration.

As more pretreatment imaging becomes integrated into the treatment planning process and full three-dimensional image-guidance becomes part of the treatment delivery the need for a deformable image registration technique becomes more apparent. A novel finite element model-based multi-organ deformable image registration method, MORFEUS, has been developed. The basis of this method is twofold: first, individual organ deformation can be accurately modeled by deforming the surface of the organ at one instance into the surface of the organ at another instance and assigning the material properties that allow the internal structures to be accurately deformed into the secondary position and second, multi-organ deformable alignment can be achieved by explicitly defining the deformation of a subset of organs and assigning surface interfaces between organs. The feasibility and accuracy of the method was tested on MR thoracic and abdominal images of healthy volunteers at inhale and exhale. For the thoracic cases, the lungs and external surface were explicitly deformed and the breasts were implicitly deformed based on its relation to the lung and external surface. For the abdominal cases, the liver, spleen, and external surface were explicitly deformed and the stomach and kidneys were implicitly deformed. The average accuracy (average absolute error) of the lung and liver deformation, determined by tracking visible bifurcations, was 0.19 (s.d.: 0.09), 0.28 (s.d.: 0.12) and 0.17(s.d.:0.07)cm, in the LR, AP, and IS directions, respectively. The average accuracy of implicitly deformed organs was 0.11 (s.d.: 0.11), 0.13 (s.d.: 0.12), and 0.08(s.d.:0.09)cm, in the LR, AP, and IS directions, respectively. The average vector magnitude of the accuracy was 0.44(s.d.:0.20)cm for the lung and liver deformation and 0.24(s.d.:0.18)cm for the implicitly deformed organs. The two main processes, explicit deformation of the selected organs and finite element analysis calculations, require less than 120 and 495s, respectively. This platform can facilitate the integration of deformable image registration into online image guidance procedures, dose calculations, and tissue response monitoring as well as performing multi-modality image registration for purposes of treatment planning.
Cadherin switching

The cadherin molecules at adherens junctions have multiple isoforms. Cadherin isoform switching (cadherin switching) occurs during normal developmental processes to allow cell types to segregate from one another. Tumor cells often recapitulate this activity and the result is an aggressive tumor cell that gains the ability to leave the site of the tumor and metastasize. At present, we understand some of the mechanisms that promote cadherin switching and some of the pathways downstream of this process that influence cell behavior. Specific cadherin family members influence growth-factor-receptor signaling and Rho GTPases to promote cell motility and invasion. In addition, p120-catenin probably plays multiple roles in cadherin switching, regulating Rho GTPases and stabilizing cadherins.
A Model of Lean Management for Organizational Innovation: Cases in Visegrád and AFTA

Abstract Originated as a production management philosophy, Lean Manufacturing has successfully transferred and implemented globally. Lean genealogy studies have been conducted, indicating the essential concept now evolves to Lean Management (LM), which is applicable to many branches of production and services management, viz quality and productivity, human resources, knowledge and technology, etc. Innovation has been made to ensure a smooth customization of knowledge and principles, tailored to each organization who is eager to implement this state-of-the-art management system. However, failures are becoming commonplace due to the lack of understanding the core values, and insufficient intensification of compensation for cultural differences. In this paper, cases of implementing LM across the Visegrád group (V4) and the ASEAN Free Trade Area (AFTA) from previous literature are taken into consideration. Factors that differentiate the characteristic of LM are brought to discussion. Therefore, the discovered gap between the two trade blocs urges the in-depth amendment and modification of employed concepts, tools, etc. A model is consequently elaborated, which aims at facilitate the managerial decision-making process regarding knowledge transfer of LM between V4 and AFTA, based on critical factors related to human, technology and culture, i.e. Labor cost, Manual requirement, Awareness, Continuous Improvement culture. This model can be used to predict the change should be made, or the criterion should be fulfilled to transfer the implementation and knowledge of LM effectively.
Case Management for People with Dementia and its Translations: A Discussion Paper

Case management is generally seen as a way to provide efficient, cost-saving person-centred care for people with dementia by connecting together fragmented services, but the available evidence in favour of its merits is often considered inconclusive, unclear and sketchy. This discussion paper investigates the evidence of the benefit of case management for people with dementia and explores the complexity of the concept and the experiences of its implementation. It offers a comprehensive framework for conceptualising various types of case management and asks the question: who can be a case manager? Building on examples from three European countries it addresses the problem of the expansion and adoption of the case management method. It compares the conventional model of diffusion of innovation with the ideas of interessement and co-constitution and envisions a successful model of case management as a fluid technology that is both friendly and flexible, allowing it to adapt to different settings and systems.
AAODV Routing Protocol: The Impact of the Routing Metric on the Performance of Wireless Mesh Networks

In this paper, a new routing protocol, named Adaptive Ad hoc On-Demand Distance Vector (AAODV) is presented. AAODV is based on Ad hoc On-Demand Distance Vector (AODV) protocol. Unlike AODV, this protocol is able to establish routes using any of the routing metrics calculated per link, due to its ability to separate paths quality monitoring from routing. In the paper AAODV uses, but it is not limited to, the following per link calculated metrics: hop count, delay, jitter and Expected Transmission Count. We analyze their influence on the overall performance of the Wireless Mesh Network, considering the triplet: packet loss ratio, delay and jitter. The simulations are realized using ns-3 simulator on eight randomly generated topologies with different traffic patterns. The results obtained have shown that in case of random topologies none of the routing metrics used provides significantly better results than the other ones. In order to increase the network performance, the transition to a multi-path routing protocol based on traffic aware metrics may be necessary.
[Expression and effects of nuclear distribution C (NUDC) protein in nasopharyngeal carcinoma cell lines].

BACKGROUND & OBJECTIVE Nuclear migration is essential for growth, development, and cellular function of eukaryotes. Nuclear distribution C (NUDC) protein plays an important role in nuclear migration. This study was to detect the expression of NUDC protein in nasopharyngeal carcinoma (NPC) cell lines CNE-2 and HNE-2, and to investigate the effect of anti-NUDC antibody on the growth of both cell lines. METHODS Soluble fusion protein GST-NUDC was expressed in the cytoplasm of Escherichia coli, and its poly-antibody was prepared. The subcellular localization of NUDC protein in CNE-2 and HNE-2 cells was detected with indirect immunofluorescent staining, the expression of NUDC protein in CNE-2 and HNE-2 cells was detected by Western blot, the effect of anti-NUDC antibody on the growth of CNE-2 and HNE-2 cells was detected by MTT assay. RESULTS NUDC protein was expressed in both nasopharyngeal non-cancerous tissues and CNE-2 and HNE-2 cells, and its expression was higher in CNE-2 and HNE-2 cells than in nasopharyngeal non-cancerous tissues. NUDC protein in CNE-2 and HNE-2 cells was distributed mainly in the karyolemma of cytoplasm, and in nuclei asymmetrically. Anti-NUDC antibody inhibited the growth of CNE-2 and HNE-2 cells in a dose-dependent manner. CONCLUSIONS NUDC protein is expressed highly in CNE-2 and HNE-2 cells. Anti-NUDC antibody could inhibit the growth of CNE-2 and HNE-2 cells.
CARMA: Contention-aware Auction-based Resource Management in Architecture

As the number of resources on chip multiprocessors (CMPs) increases, the complexity of how to best allocate these resources increases drastically. Because the higher number of applications makes the interaction and impacts of various memory levels more complex. Also, the selection of the objective function to define what \enquote{best} means for all applications is challenging. Memory-level parallelism (MLP) aware replacement algorithms in CMPs try to maximize the overall system performance or equalize each application's performance degradation due to sharing. However, depending on the selected \enquote{performance} metric, these algorithms are not efficiently implemented, because these centralized approaches mostly need some further information regarding about applications' need. In this paper, we propose a contention-aware game-theoretic resource management approach (CARMA) using market auction mechanism to find an optimal strategy for each application in a resource competition game. The applications learn through repeated interactions to choose their action on choosing the shared resources. Specifically, we consider two cases: (i) cache competition game, and (ii) main processor and co-processor congestion game. We enforce costs for each resource and derive bidding strategy. Accurate evaluation of the proposed approach show that our distributed allocation is scalable and outperforms the static and traditional approaches.
Gender Differences of Enzymatic Activity and Distribution of 17β-Hydroxysteroid Dehydrogenase in Human Skin in vitro

The interconversion of estrone (E1) and 17β-estradiol (E2) is catalyzed by 17β-hydroxysteroid dehydrogenase (17β-HSD) in peripheral steroidogenic organs such as the skin. To investigate gender differences of activity and skin distribution of 17β-HSD in human skin, enzymatic activity was measured in skin homogenates and skin horizontally sliced by 10 µm thickness in vitro. Reductive 17β-HSD (E2 formation from E1) in female skin has a lower substrate affinity than in male skin; Km (Michaelis-Menten constant) of female and male skin is 11.8 ± 6.5 and 2.0 ± 2.0 µM, respectively. Female skin had a tendency to activate estrogen; Vmax (maximum rate) for E2 formation, 5.8 ± 4.0 pmol/min/mg protein, is 1.7 times larger than E1 formation, 3.5 ± 1.5 pmol/min/mg protein, and, on the other hand, male skin tends to deactivate estrogen; Vmax for E1 and E2 is 10.5 ± 6.1 and 4.2 ± 3.7 pmol/min/mg protein, respectively. The concentration of metabolite had a peak value at 80–120 µm from the skin surface. Therefore, these in vitro results suggest that the enzymatic activities of 17β-HSDs have a gender difference in estrogen formation/metabolism and are distributed around the basement layer of the epidermis irrespective of sex. 17β-HSDs distributed around the basement epidermis may be effectively supplied with circulating estrogen from the papillary plexus to maintain the estrogen level in skin. This distribution pattern having a peak surrounding 100 µm from the skin surface indicates the importance for defense from noxae (e.g. detoxication) and maintenance of the internal environment (e.g. biosynthesis of hormones). Future studies should increase sample size and confirm these results by stricter statistical analysis.
The Impact of Different Organizational Cultures on IT Outsourcing Relationship Management

Globalization has affected the organizations in many aspects such as structure, architecture, internal/external strategies and sourcing management. Outsourcing is one of the recent business strategies used to provide IT needs via external agents. The relationship between the service buyer and provider companies is a constituent playing a significant role in IT outsourcing success or failure. This research has a focus on the influence of organizational culture of buyer companies on the specific factors of trust, cooperation, communication and commitment in their relationship with the IT service provider. Two explorative case studies are done in global companies using ITO which revealed the presence of organizational culture effect. Particularly, being innovative, having open discussion as an organizational culture and looking for extending contracts with providers as a strategy, appeared as the major difference between the two cases organizational culture; which influences the studied factors of ITO relationship in this research.
L'activité métalinguistique de lecteurs francophones débutants en espagnol

Cette etude s'inscrit dans le cadre d'un programme de recherche sur l'intercomprehension entre locuteurs de langues romanes (programme galatea). On s'y interesse aux processus et strategies utilises pour la construction du sens par des francophones confrontes a la lecture de textes en espagnol alors que cette langue est inconnue d'eux. A travers le recueil des discours produits par les sujets pendant cette activite, et immediatement apres au cours d'un entretien semi-structure avec le chercheur, il s'agit de reperer, recenser et classer les differents aspects de leur reflexion verbalisee. L'analyse porte plus specifiquement sur les aspects metalinguistiques, a savoir sur la mise en oeuvre consciente et deliberee des savoir-faire, representations et connaissances linguistiques. Une prise en compte du degre de sollicitation (variable au fil de l'entretien), et du degre de formalisation des discours selectionnes, permet d'en proposer une typologie. Les aspects les plus saillants de cette activite metalinguistique (role de la langue maternelle et des autres langues connues, conscience de la proximite typolinguistique, metalangue utilisee. . . ) sont abordes a travers la discussion des criteres de classement utilises (obje t linguistique concerne, degre de generalisation, transfert ou conceptualisation. . . ). Suite a la consideration des potentialites metalinguistiques recensees, des indications pour une elaboration didactique ulterieure faisant largement appel a l'activite "meta", sont suggerees.
Growth kinetics of Lactobacillus acidophilus under ohmic heating

Lactobacillus acidophilus OSU133 was inoculated into MRS broth in a fermenter vessel and incubated at 30, 35, or 45°C with agitation. Incubation temperatures were attained by conventional or ohmic heating. An electrical current at low (15 V) or high (40 V) voltage was used to heat the culture directly during fermentations under ohmic heating. The growth parameters (lag period, minimum generation time, and maximum growth) and changes in pH were determined during fermentation. Metabolic activities (consumption of glucose and production of lactic acid and bacteriocin) were determined during fermentation at 35°C under both heating methods. Lag period for L. acidophilus was affected appreciably by the method of heating, but the magnitude of these changes depended on the fermentation temperature. When fermentation was done at 30°C, lag period decreased by 94% under low‐voltage ohmic, compared with conventional, heating methods. Ohmic heating did not change the generation time significantly and caused slight, but significant (p < 0.01) decrease in maximum growth. Therefore, the electric current enhances the early stages, but it inhibits the late stages of growth. Ohmic, compared with conventional, heating resulted in higher final pH and lower bacteriocin activity in the fermented medium. However, ohmic heating at 35°C had minimal effect on glucose utilization and lactic acid production by L. acidophilus. Results show that measurement of the electric current when ohmic heating is done at a constant voltage may be used in monitoring such fermentations. In conclusion, ohmic heating is potentially useful in certain applications related to fermented foods. © 1996 John Wiley & Sons, Inc.
SIFT FEATURE BASED DETECTION OF GLAUCOMA

The normal and glaucomatous fundus images are classified using Support Vector Machines (SVM) and Naïve Bayes in this paper. The features of both classes of images are extracted using the Scale Invariant Feature Transform (SIFT). Two optimal features are then utilized by the SVM Classifier to classify the images into the two respective categories and its performance is compared with that of the Naive Bayes classifier. Keywords— Glaucoma, Naïve Bayes, Scale Invariant Feature Transform, Support Vector Machine.
Real-Time Predictive Analytics for Sepsis Level and Therapeutic Plans in Intensive Care Medicine

Optimal treatments for patients with microbiological problems depend significantly on the ability of the attending physicians to predict sepsis level. A set of Data Mining (DM) models has been developed using forecasting techniques and classification models to aid decision making by physicians about the appropriate, and most effective, therapeutic plan to adopt in specific situations. A combination of Decision Trees, Support Vector Machines and Naive Bayes classifier were being used to generate the DM models. Confusion Matrix, including associated metrics, and Cross-validation were used to evaluate the models. Associated metrics used to identify the most relevant measures to predict sepsis level and treatment procedures include the analysis of the total error rate, sensitivity, specificity, and accuracy measures. The data used in DM models were collected at the Intensive Care Unit of the Centro Hospitalar do Porto, in Oporto, Portugal. Encapsulated within a supervised learning context, classification models were applied to predict sepsis level and direct the therapeutic plan for patients with sepsis. This work concludes that it was possible to predict sepsis level (2nd and 3rd) with great accuracy (accuracy: 100%), but not for the therapeutic plan (best accuracy level: 62.8%).
Role of HR in Change Management – A Comparative Analysis of Indian and Foreign Companies

HR has moved away from its traditional role and the need of the business is that HR should become a more Strategic player. Today Change is seen as the new norm in the present business environment, rightly described by the term VUCA, volatile, uncertain, complex and Ambiguous, HR should be proactive in sensing the changes that the business could face and adopting policies and practices to address them. This research aims at finding the Role of HR in managing Change and also critically analyses the HR Readiness to Change management between Indian(domestic) and foreign firms. There is a paradigm shift in HR competences required for handling the present and upcoming challenges. Firm Ownership is viewed as a determinant in the design of HR strategy, policy and practices formation. This research finds that there are significant differences between Indian and Foreign Companies in the areas of HR Involvement in Change Management, Pre-implementation, Training for Change, Post-implementation and HR Competency Development. However it was found that there are no significant differences only in the Transition Stage. It can be concluded that though there are differences, the variance lies basically in the extent of implementation of these practices. Further research could be carried out extending it to include other sectors, region wise segregation of foreign companies, different structures of firm ownership, like public sector, Joint ventures, familyowned businesses etc.
Arthrose des membres inférieurs : aspects épidémiologiques, cliniques et fondamentaux

L’arthrose est une pathologie frequente et responsable d’une morbidite majeure. En France, cette pathologie est devenue une priorite de sante publique et jusqu’a recemment il n’existait aucune donnee epidemiologique en population generale. Mon travail a permis d’apporter les premiers chiffres de prevalence en population generale et a constitue une etape preliminaire essentielle a la realisation d’une etude de prevalence nationale et a la constitution d’une cohorte de cas prevalents d’arthrose symptomatique des membres inferieurs. Ces travaux m’ont amene a m’interesser a l’apport diagnostique des cliches en Schuss et ainsi mettre en evidence que ces cliches seuls sont aussi contributifs que l’association cliches en extension et cliches en Schuss classiquement realises pour le diagnostic de gonarthrose. L'ocytocine est une hormone exprimee dans un grand nombre de cellules dont les osteoblastes et les adipocytes. Son role dans l'osteoporose a ete demontre. A ce jour aucune donnee sur son eventuel role dans l’arthrose n’a ete publiee. J’ai donc recherche un eventuel role direct et/ou indirect de l'ocytocine. Pour cela, nous avons utilise un modele cellulaire: ’’Multipotent Adipose-Derived Stem’’ (hMADS) developpe dans notre laboratoire de recherche. Nous avons, dans un premier temps, montre les capacites chondrogeniques de ces cellules ainsi que leur interet comme potentiel outil de tests pharmacologiques dans l’arthrose. La deuxieme etape a consiste a demontrer un role de l’ocytocine dans la chondrogenese. Nous avons montre que l’ocytocine a une action benefique sur l’expression des genes chondrocytaire. De plus, le traitement des cellules par l'ocytocine attenue l'effet negatif de l'IL-1β sur ADAMTS-4 qui est responsable de la degradation de l'aggrecane. L’ensemble de ces resultats indique que l'ocytocine represente un modulateur positif de la formation des chondrocytes et prometteur comme traitement potentiel pour l'arthrose.
Reactions of healthy persons and persons suffering from allergic rhinitis when exposed to office dust.

OBJECTIVES Reactions to airborne office dust among healthy subjects and subjects suffering from allergic rhinitis were investigated. METHODS Twelve healthy and 11 subjects suffering from allergic rhinitis were exposed to clean air [17 (SD 2) microg/m3] and office dust [439 (SD 68) microg/m3] for 245 minutes. The effect measurements included subjective sensations (questionnaire and potentiometer ratings), mood scale, peak flow, bronchial provocation with histamine using forced expiratory volume in 1 second as the effect measure, nasal mucosal swelling, tear film stability, epithelial damage, foam formation in the eye canthus, threshold for eye irritation with carbon dioxide, eye redness, cellular content of conjunctival fluid, and an addition test for distraction. As many investigations were made and as many statistical analyses (including subgroup analyses) were carried out, the risk of mass significance appeared. This problem was dealt with using the Bonferroni correction for multiple significance tests. RESULTS The mean ratings of the potentiometer were higher (the subjects showed more irritation) during the dust exposure. The objective investigations showed only indications of effects of dust exposure, and some of the indications were in biologically unexplainable directions. No difference in the reactions to dust was observed between the healthy subjects and the subjects suffering from allergic rhinitis. CONCLUSIONS Dust does not seem to have objective or subjective effects on humans, as only indications of dust effects were found. Subjects suffering from allergic rhinitis do not appear to be a risk group in relation to dust exposure.