Miracle-dz/UniFAR-FTUs huggingface dataset:
A pilot study of sentinel lymph nodes identification in patients with endometrial cancer.

PURPOSE The purpose of this study was to investigate the feasibility of sentinel lymph node (SLN) identification in patients with endometrial cancer. METHODS Twenty patients with endometrial cancer undergoing hysterectomy and lymphadenectomy were included in the study. At laparotomy, methylene blue dye was injected into the subserosal myometrium of corpus uteri at multiple sites. Dye uptake into lymphatic channels was observed and blue nodes were identified as SLNs. The SLNs were biopsied before lymphadenectomy performed. The samples of SLNs and non-SLNs were recorded separately and correlated with the final pathological results. RESULTS Dye uptake into lymphatic channels was seen in all 20 cases. Among them, SLN was identified in 15 (75%) cases. A total of 71 SLNs with a mean number of 4.7 SLN (range, 1-10) were identified from all pelvic sites. The most frequent locations of SLNs included obturator in 29 (41%), interiliac in 16 (26%). No dye-containing paraaortic nodes were found. Two patients (10%) had nodal metastases, and they all had at least one SLN found to be positive. No adverse reactions or injures were attributed to the study. CONCLUSIONS This study shows the feasibility and safety of SLN identification with blue dye in patients with endometrial cancer undergoing staging surgery. The approach might provide an alternative to limit the extent of nodal sampling.
Effectiveness and safety of warfarin initiation in older hemodialysis patients with incident atrial fibrillation.

BACKGROUND AND OBJECTIVES Although generally recommended in atrial fibrillation (AF) patients, the effectiveness and safety of oral anticoagulation in dialysis patients with AF is unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS We assembled a cohort of older hemodialysis patients who initiated dialysis without prior record of AF and who had prescription drug benefits through three state-administered programs. The index event was a first hospitalization with diagnosed AF; patients with any recorded prior warfarin use were excluded. Eligible patients survived ≥30 days from discharge, and new warfarin use was recorded from prescription records during that 30-day window. Propensity-matched warfarin users and nonusers were compared using Cox regression. Outcomes included ischemic stroke, hemorrhagic stroke, and mortality. RESULTS Among 2313 patients with new AF who survived 30 days from discharge, 249 (10.8%) filled a prescription for warfarin. Comparing 237 warfarin users and 948 propensity-matched nonusers over 2287 person-years of follow-up, the occurrence of ischemic stroke was similar (HR = 0.92; 95% CI, 0.61 to 1.37), whereas warfarin users experienced twice the risk of hemorrhagic stroke (HR = 2.38; 95% CI, 1.15 to 4.96). The risks of stroke, gastrointestinal hemorrhage, and mortality did not differ between groups. As-treated analyses yielded similar findings, as did analyses restricted to patients with CHADS(2) scores ≥2. CONCLUSIONS Although we confirmed association between warfarin use and hemorrhagic stroke in dialysis patients with AF, we found no association between warfarin use and ischemic stroke. Adequately powered randomized trials are required to conclusively determine the risks and benefits of the studied warfarin indication in hemodialysis patients.
HSV-UL18 DNA vaccine construction and immunodetection.

Herpes simplex virus (HSV-1) is a common pathogen that causes skin and venereal diseases. To date, a cure for this pathogen does not exist. Therefore, the development of a vaccine to prevent infection with the virus seems to be the best solution. DNA vaccines represent a novel vaccine formulation, which is able to induce an immune response. In the present study, we used genetic engineering technologies to ligate the HSV-1 protein Vp23 into the pcDNA3.1 plasmid, resulting in the constructed plasmid pcDNA3.1-UL18, the potential DNA vaccine against HSV- 1.The pcDNA3.1-UL18 (p-Vp23) was used for mice immunization. Determination of serum IgG levels, serum neutralization antibody titers, proliferation of spleen lymphocytes, Delayed Hypersensitivity Test reaction, as well as detection of the inflammatory factors IFN-, IL-2, IL-4 and IL-10 in spleen cells revealed that the constructed p-Vp23, to a certain extent, was able to induce immune response in mice.
Plasminogen activator inhibitor-1 aids survival of neurites on neurons derived from pheochromocytoma (PC-12) cells

Plasminogen activator inhibitor-1 is a serpin that regulates the activities of plasminogen activators. However, its physiological roles in the CNS are incompletely understood. We have found that plasminogen activator inhibitor-1 has a novel biological function in the CNS: the contribution to survival of neurites on neurons. PC-12 cells treated with nerve growth factor differentiated into neurons and formed a network of neurites. In a serum-free culture medium, these neurites disappeared within 24 h. The addition of plasminogen activator inhibitor-1 prevented the disintegration of the neuronal networks, while the addition of the serpin inhibitors aprotinin and antipain did not. The plasminogen activator inhibitor-1 maintained or promoted the phosphorylated state of extracellular signal-regulated kinase (ERK), but not of protein kinase B (Akt). These results are the first evidence that plasminogen activator inhibitor-1 in the CNS acts to maintain the morphology of neurites via activation of the ERK-related pathway in the neurons.
The Impact of Obesity on the Association between Obstructive Sleep Apnea and Glucose Metabolism.

1. Bakker JP, Weng J, Wang R, Redline S, Punjabi NM, Patel SR; The MultiEthnic Study of Atherosclerosis. Associations between obstructive sleep apnea, sleep duration, and abnormal fasting glucose. Am J Respir Crit Care Med 2015;192:745–753. 2. Twedt R, Bradley M, Deiseroth D, Althouse A, Facco F. Sleep duration and blood glucose control in women with gestational diabetes mellitus. Obstet Gynecol 2015;126:326–331. 3. Chen X, Wang R, Zee P, Lutsey PL, Javaheri S, Alcántara C, Jackson CL, Williams MA, Redline S. Racial/ethnic differences in sleep disturbances: the multi-ethnic study of atherosclerosis (MESA). Sleep 2015;38:877–888. 4. Peterson BT, Chiao P, Pickering E, Freeman J, Zammit GK, Ding Y, Badura LL. Comparison of actigraphy and polysomnography to assess effects of zolpidem in a clinical research unit. Sleep Med 2012; 13:419–424. 5. Grandner MA, Hale L, Moore M, Patel NP. Mortality associated with short sleep duration: the evidence, the possible mechanisms, and the future. Sleep Med Rev 2010;14:191–203. 6. Jackson CL, Redline S, Kawachi I, Williams MA, Hu FB. Racial disparities in short sleep duration by occupation and industry. Am J Epidemiol 2013;178:1442–1451. 7. Eastwood PR, Malhotra A, Palmer LJ, Kezirian EJ, Horner RL, Ip MS, Thurnheer R, Antic NA, Hillman DR. Obstructive sleep apnoea: from pathogenesis to treatment. Current controversies and future directions. Respirology 2010;15:587–595.
Patient Flow in Hospitals: Understanding and Controlling It Better

Summary • Because waits, delays, and cancellations are so common in healthcare, patients and providers assume that waiting is an inevitable, but regrettable, part of the care process. For years, hospitals responded to delays by adding resources—more beds and buildings or more staff— as the only way to deal with an increasingly needy population. Furthermore, as long as payment for services covered the costs, more construction and more staff allowed for continued inefficiencies in the system. Today, few organizations can afford this solution. Moreover, recent work on assessing the reasons for delays suggests that adding resources is not the answer. In many cases, delays are not a resource problem; they are a flow problem. The Institute for Healthcare Improvement has worked with more than 60 hospitals in the United States and the United Kingdom to evaluate what influences the smooth and timely flow of patients through hospital departments and to develop and implement methods for improving flow. Specific areas of focus include smoothing the flow of elective surgery, reducing waits for inpatient admission through emergency departments, achieving timely and efficient transfer of patients from the intensive care unit to medical/surgical units, and improving flow from the inpatient setting to long‐term‐care facilities.
Potential benefits of Pet-Facilitated-Therapy (PFT) in children with Autism Spectrum Disorder (ASD)

Abstract: Autism Spectrum Disorder (ASD) is a wide range of social, mental, and developmental disorder seen among the young children. It is commonly used to describe individuals who have autism or autistic type features. And it is mentioned as a spectrum since different individuals with autism shows different symptoms rather than one single disorder. However, they have some basic features to mention them generally as having autism such as deficits in social interaction, communication and the presence of restricted or repetitive behaviors. Autism seems to be related with genetic, non-genetic or environmental factors. Since the causes of ASD are not clear, the specific treatments of it are still lacking. Alternative and complementary therapies such as diet, exercise, medications, acupuncture are utilized for improving the conditions of the children with ASD. Pet facilitated therapy (PFT) has been increasingly popular in recent years and it is counted as one form of alternative therapies in human medical field in some countries. The purpose of this study is to examine the potential benefits of PFT that would offer to the children with ASD. The findings revealed that pet therapy is considered as highly beneficial and recommended as one of the alternative therapies. The findings are categorized into different themes such as potential benefits of PFT in physical movement; communication, social and language skills; improving positive behaviors and reducing negative behaviors; and stress in children with ASD. This study is hoped to give insight to public, health care professions so that they can make use of PFT in providing effective care to the children with ASD.
Design of a thrust-vectoring tailcone based on 3-RRRR parallel manipulator for small-size autonomous underwater vehicles

A vectored thruster based on 3-RRRR parallel manipulator for small-size AUVs is designed to solve some drawbacks of conventional AUVs, which the control surfaces become ineffective at zero or slow forward speeds. Though this method, the thrust from duck propeller is controlled by the parallel manipulator. This approach has advantages of high stiffness, high mobile and large payload capacity. The parallel manipulator is analyzed in kinematics and is emulated in MATLAB to verify the performance of the vectored thrust control system. The vectored thrust control system designed in this paper with high rapid response capabilities is an effective method to expand the application range of small-size AUVs.
The Role of Body Mass Index in the Relative Risk of Developing Premenopausal versus Postmenopausal Breast Cancer

Abstract Many women in industrialized countries are overweight. Excess body fat is associated with excess morbidity and mortality from atherosclerosis and diabetes. In some cases, overweight/obesity also is implicated with increased incidence of breast cancer, but the results of these studies are not consistent. Human breast cancer is usually distinguished as either premenopausal or postmenopausal. In this review, we focus on literature that presents body mass index (BMI, weight/height2) ranges and identifies menstrual status. The majority of the relevant prospective studies support an inverse relationship between BMI and the relative risk (RR) of developing premenopausal breast cancer. In contrast, a positive relationship between BMI and the RR of developing postmenopausal breast cancer is reported in only half of all prospective studies on this topic. Those studies that do not show a positive RR, in general, have used younger postmenopausal women, and their body weights were obtained prior to menopause. Many case-control studies also report an inverse association between BMI and the RR of developing premenopausal breast cancer, and a positive association between BMI and the RR of developing postmenopausal breast cancer. Other studies do not find these associations, but a number of these studies have used small sample sizes and, for the postmenopausal subjects, have represented populations with low obesity and/or breast cancer rates. Other factors that might play a role in breast cancer development, such as body fat distribution, weight at earlier ages, and weight gain, are also addressed, as well as the effect of obesity in breast cancer prognosis. In addition, limited data available for animal studies related to this topic, as well as potential mechanisms by which body fat may play a role in breast cancer development, are discussed. Finally, the need for better animal models in which to perform controlled dietary and/or drug intervention studies to test rigorously the proposed mechanisms by which body fat may contribute to breast cancer development is addressed.
Polymorphic Worms Detection Using A Supervised Machine Learning Technique

Polymorphic worms are considered as the most dangerous threats to the Internet security, and the danger lies in changing their payloads in every infection attempt to avoid the security systems. We have designed a novel doublehoneynet system, which is able to detect new worms that have not been seen before. To generate signatures for polymorphic worms we have two steps. The first step is the polymorphic worms sample collection which is done by a Double-honeynet system. The second step is the signature generation for the collected samples which is done by using a Support Vector Machines (SVMs) technique. The system is able to generate accurate signatures for single and multiple worms. Keywords-honeynet; worms; machine learning algorithm.
Designing directional antenna with magnetic artificial materials

We introduce the application of magnetic artificial materials in the design of directional antenna. Two ways to use magnetic materials to enhance the directional radiation of sources are demonstrated. One way is the left-handed materials (LHMs) and the other is electromagnetic bandgap (EBG) structures. In both cases, the radiation of the antenna exhibits good radiation performance but the underlying mechanisms are different. The special advantage of the antenna designed by LHM is its lower radar cross section, whereas the one by magnetic EBG structures is the frequency tunability.
Colon straightening based on elastic mechanics model

Early detection and removal of polyps can reduce mortality due to colon cancers. In CT colonography, colon straightening can facilitate visualization and detection of polyps. We presented a new method to straighten the colon based on an elastic deformation model with specially designated boundary conditions and centerline constraints. With a digitally generated phantom it was demonstrated that the elastic deformation model can straighten the colon in a consistent manner (i.e., to preserve the relative spatial relationships of points on the colon surface, such as left vs. right, up vs. down) and can handle large-angle bendings in colon geometry. It was observed that the proposed model may impose relatively small distortion effects on structures on the colon surface after straightening. Further research was mentioned.
Automatic face-based image grouping for albuming

In this paper, a system for automatic albuming of consumer photographs is described, that uses face-based information extracted from images. The target image sets for this work are snapshots from family photo collections. The aim is to automatically provide the user with the option of selecting image groups based on the people present in them. The core components of age/gender classification and clustering based on facial similarity for this domain are discussed. Age and gender classification based on individual facial feature measurements combined to produce a single classifier using the AdaBoost algorithm. Face-based information is used both in locating suitable images and layout/design phases of the albuming process. Face-based information is combined with earlier work on event segmentation and layout design to provide a more effective system. Performance is tested on two family photo databases covering a 5 year time-span.
Le parcours du downstep; ou l'évolution d'une notion

Cet article retrace l'histoire du « downstep » (ou abaissement de registre tonal) qui a debute il y a plus d'un siecle. Cette notion, importante dans les etudes prosodiques actuelles, s'est developpee dans un aller et retour constant entre etudes de terrain et modeles theoriques. Son evolution a egalement ete liee a celle des modeles phonologiques, en particulier au developpement des conceptions multilineaires actuelles. De fait, le parcours du «downstep» nous conduit au cœur meme de l'histoire de la phonologie, de la conception unilineaire des sons du langage qui a prevalu jusqu'a la fin des annees soixante-dix, de l'evolution du traitement des faits suprasegmentaux, de la formation de modeles a plusieurs lignes, etc. Son histoire a ete fondamentalement determinee par sa nature non segmentale, c'est-a-dire non reductible a la taille d'une consonne, d'une voyelle ou d'un ton. «Le parcours du downstep» s'entend egalement du point de vue geographique: sa naissance a ete africaine mais il a connu une large diffusion, favorisee par certains modeles theoriques et il est maintenant utilise dans l'analyse d'un grand nombre de langues de familles diverses (somali, anglais, neerlandais, francais, japonais .). Son long periple, son identification dans des systemes prosodiques tres divers ont evidemment modifie le contenu meme de la notion de downstep. Depuis la reconnaissance initiale de Christaller (1875) d'un ton haut « abaisse », qui reste un ton haut et ne devient pas un ton moyen, la notion de downstep s'est progressivement - et difficilement - detachee de celle de ton moyen. Elle a ete mise en rapport, dans certaines langues, avec des tons dits «flottants» (notion qui a ete formee dans les annees soixante). Ulterieurement, le role demarcatif et hierarchisant du downstep a ete mis en evidence dans des systemes divers. Sa nature phonetique a ete precisee et il apparait de plus en plus qu'il ne consiste pas uniquement en un abaissement de registre mais qu'il met aussi en jeu des anticipations et des relevements de registres (au point que certains auteurs se demandent actuellement s'il y a meme rabaissement). Des emboitements de downsteps - a valeur hierarchique - ont egalement ete degages. L'histoire de cette notion n'est pas close et la notion de downstep peut encore evoluer, surtout, du fait de l'accroissement actuel des etudes portant sur les registres (leur translation, leur expansion, leur role ) dans la modelisation de la prosodie.
The UAE wind turbine performance prediction using wind tunnel airfoil data

It's vitally important for wind turbine aerodynamic performance predictions to design and optimize wind turbines. In view of the BEM method's fast speed and widespread use, this paper applies WT_Perf software of NREL to predict the performance on a NREL Phase VI upwind wind turbine. Measurements from the Phase VI of the NREL/NASA Ames wind tunnel test were used for validating the predictions. Performance predictions will vary greatly when data selection changes. Also three-dimensional rotational stall delay should be accounted for in the predictions. The final obtained prediction methods show good agreement with the experiments. Because of their accuracy and straightforward manufacturing, derived methods can be widely used in wind turbine optimization and design of the future research.
Challenging conventional wisdom: The etiologic role of dopamine oxidative stress in Parkinson's disease

Oxidative stress is well documented in Parkinson's disease (PD) and has been attributed to dopamine oxidative metabolism. However, evidence of oxidative stress is found in a variety of neurodegenerative disorders, suggesting that more general factors are responsible or that cytodestructive processes secondarily generate oxyradical products. Increasing evidence points away from dopamine metabolism as an important contributor to PD neurodegeneration. Predictions from the dopamine oxidative stress hypothesis of PD reveal multiple inconsistencies. Although the clinical and therapeutic importance of the nigrostriatal dopaminergic system is undeniable, PD neuropathology is much more widespread. © 2004 Movement Disorder Society
Detection methods for locating obstructions in blown optical fiber ducts

Currently obstructions in blown optical fiber (BOF) tubing (microducts) are found using the ball bearing test (BB test) as described in test method 6H1 of MIL-STD-2042. A 4.5 millimeter (.17 inch) BB is launched down the entire length of the tubing (6 mm ID) with air pressure ranging from 50 to 100 psig. The BOF tubing is considered obstruction free if the BB can traverse the entire length of the tube. If the BB does not pass through the BOF tubing, there is an obstruction at an unknown location. Determining the position of this obstruction is time consuming, and if unsuccessful the entire BOF tube has to be scrapped. There would be a cost saving benefit if an accurate way of determining the location of the obstruction was found.
[Treatment of advanced gastric cancer with oxaliplatin plus 5-fluorouracil/ leucovorin (FOLFOX-4 chemotherapy)].

BACKGROUND Chemotherapy improves survival in advanced gastric cancer. However the most active combinations have a high level of toxicity that limits their use. AIM To assess the response, toxicity and survival of patients with advanced gastric cancer, treated with oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX-4 chemotherapy). MATERIAL AND METHODS Patients with stage IV gastric cancer, according to the American Joint Committee on Cancer or with relapsed disease and functional capacity 0-2 of the South West Oncology Group, were included. FOLFOX-4 chemotherapy was used as first or second line treatment. The response to treatment and survival were assessed. RESULTS Between 2003 and 2006, 29 patients (median age 52.5 years, 69% males) were treated. FOLFOX-4 was given as first line treatment in 65% patients and as second line in 35%. There was a complete response in 4.6%, partial response in 68%, stable disease in 20.6% and progression in 6.8%. Toxicity was observed in 51% of patients, that was hematological and non hematological grade 3/4 in 14%. Median survival was 12.5 months. CONCLUSIONS FOLFOX-4 chemotherapy was active in advanced gastric cancer and had a low level of toxicity.
Glimpses of Unsurveyable Maps

That Ludwig Wittgenstein was interested in maps and map-making comes as no surprise. After all, he compares the form of a philosophical question to our common experience of disorientation – “ I don’t know my way about. ” (PI § 123) – and likens his Philosophical Investigations (PI) to an album containing sketches of a landscape which has been explored in a criss-cross manner. In this paper I present metaphors of perfect maps provided by Jorge Luis Borges, Lewis Carroll and Josiah Royce, and set these against remarks by Wittgenstein and Charles Sanders Peirce.
Online parameter identification method for IPMSM drive with MTPA

This paper presents the online identification method for interior permanent-magnet synchronous motor (IPMSM) drive system with the maximum torque per ampere (MTPA). The inductances of the motor are identified by recursive least square (RLS) method based on mathematical model, considering the flux saturation state. Using this technique, the improvement of the MTPA trajectory for IPMSM can be implemented along with the effect of magnetic flux. This final paper presents an idea and a procedure of the proposed algorithm. The simulation results are carried out and presented.