Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Eating Attitudes, Anger and Impulsivity in Atypical and Non-Atypical Depression and Assessment of Comorbidity of Binge Eating.

BACKGROUND Although there have been studies investigating emotional eating, impulsivity and anger, the relationship between differentiated eating attitudes, impulsivity and anger in atypical depression has not yet been studied. Therefore, the aim of this study was to evaluate eating attitudes, impulsivity and anger in participants with atypical and non-atypical depression and to compare their behaviours with those of the control group. Binge eating comorbidity was also investigated. The relationship between eating attitudes, impulsivity and anger was explored and the factors contributing to disordered eating attitudes were analysed. SUBJECTS AND METHODS The participants were divided into three groups; 56 with atypical depression, 36 with non-atypical depression and 32 healthy controls for comparison. Clinical assessment was carried out using the Structured Clinical Interview for DSM-IV Axis I Disorders, Barratt Impulsiveness Scale, Multidimensional Anger Scale, Eating Attitude Test, and Hamilton Depression Scale. RESULTS Deteriorated eating attitudes, increased anger symptoms and motor impulsivity were observed more in participants with atypical depression compared with participants with non-atypical depression. The frequency of binge eating was statistically significantly higher in participants with atypical depression (50%) than in participants with non-atypical depression (8%). A positive relationship was identified between deteriorated eating attitude, anger, and impulsivity. Behaving anxiously as a reaction to anger was found to be the significant predictor of disordered eating attitudes in participants with depression. The percentage of the variance explained by anxious behavior in disordered eating attitudes was 7%. CONCLUSION Participants in the atypical and non-atypical depression groups can be differentiated from each other based on their eating attitudes, anger symptoms, motor impulsivity and binge eating frequency.
Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation

Eosinophils are key effector cells in allergic diseases. Here we investigated Mcl-1 (an anti-apoptotic protein) in experimental allergic airway inflammation using transgenic overexpressing human Mcl-1 mice (hMcl-1) and reducing Mcl-1 by a cyclin-dependent kinase inhibitor. Overexpression of Mcl-1 exacerbated allergic airway inflammation, with increased bronchoalveolar lavage fluid cellularity, eosinophil numbers and total protein, and an increase in airway mucus production. Eosinophil apoptosis was suppressed by Mcl-1 overexpression, with this resistance to apoptosis attenuated by cyclin-dependent kinase inhibition which also rescued Mcl-1-exacerbated allergic airway inflammation. We propose that targeting Mcl-1 may be beneficial in treatment of allergic airway disease.
Histone acetyltransferase inhibition rescues differentiation of emerin‐deficient myogenic progenitors

Emery‐Dreifuss muscular dystrophy (EDMD) is a disease characterized by skeletal muscle wasting, major tendon contractures, and cardiac conduction defects. Mutations in the gene encoding emerin cause EDMD1. Our previous studies suggested that emerin activation of histone deacetylase 3 (HDAC3) to reduce histone 4‐lysine 5 (H4K5) acetylation (ac) is important for myogenic differentiation.
Prevalence of depressive symptoms among Italian medical students: The multicentre cross-sectional “PRIMES” study

Background Four percent of the world’s population suffers from depression, which is a major public health issue. Medical students are at risk, as their depressive symptoms (DS) prevalence is reported to be approximately 27% worldwide. Since few data on Italian medical students exist, this study aimed to estimate their DS prevalence and assess risk and protective factors. Methods The PRIMES was a multicentre cross-sectional study performed in 12 Italian medical schools. Questionnaires were self-reported and included 30 sociodemographic items and the Beck Depression Inventory-II (BDI-II). The primary outcome was the presence of DS (BDI-II score≥14). The main analyses were chi-squared tests and multivariable logistic regressions with a p-value<0.05 considered significant. Results The number of collected questionnaires was 2,513 (117 BDI-II incomplete). Females accounted for 61.3% of the respondents, and the median age was 22 years (IQR = 4). The prevalence of DS was 29.5%. Specifically, 14.0% had mild depression, 11.1% had moderate depression, and 4.5% had severe depression. The main risk factors for DS were age, being female, bisexual/asexual orientation, living with partner/housemates, poor economic status (worsened by living far from home), less than 90 min of weekly exercise, relatives with psychiatric disorders, personal chronic disease, judging medical school choice negatively, unsatisfying friendships with classmates, competitive and hostile climate among classmates, thinking that medical school hinders specific activities and being worried about not measuring up to the profession. Protective factors included family cohesion, hobbies, intellectual curiosity as a career motivation and no worries about the future. Conclusion Italian medical students are at high risk of reporting DS, similar to the global population of medical students’. Medical schools must make efforts to implement preventive and treatment interventions by offering counselling and working on modifiable factors, such as lifestyle and learning climate.
Atrial fibrillation fingerprinting; spotting bio‐electrical markers to early recognize atrial fibrillation by the use of a bottom‐up approach (AFFIP): Rationale and design

The exact pathophysiology of atrial fibrillation (AF) remains incompletely understood and treatment of AF is associated with high recurrence rates. Persistence of AF is rooted in the presence of electropathology, defined as complex electrical conduction disorders caused by structural damage of atrial tissue. The atrial fibrillation fingerprinting (AFFIP) study aims to characterize electropathology, enabling development of a novel diagnostic instrument to predict AF onset and early progression.
Is aspirin a substrate of MDR1/P-glycoprotein?

Abstract Aspirin (acetyl salicylic acid) is widely used co-medication in patients with cardiovascular and cerebrovascular diseases. Given the prevalence of acetyl salicylic acid’s use as a co-medication and conflicting reports in the literature on it being a substrate of P-glycoprotein (P-gp). There is a potential risk for its interaction with compounds with P-gp liability, therefore, we have conducted a detailed investigation to determine substrate potential of acetyl salicylic acid towards P-gp. We observed significantly lower cellular uptake of acetyl salicylic acid in MDR1 transfected LLC-PK1 cells compared to LLC-PK1 wild-type (WT) cells, however, the in vitro efflux of acetyl salicylic acid in MDR1 transfected LLC-PK1 cells was not inhibited by known inhibitors under various conditions. Acetyl salicylic acid did not show active asymmetrical transport across MDR1 transfected LLC-PK1 cells compared to LLC-PK1-WT cells in transwell assay. Moreover, no difference in plasma and brain exposure of acetyl salicylic acid and its metabolite salicylic acid was observed between FVB-WT and Mdr1a/b knockout (KO) mice. Taken together, our findings indicate that acetyl salicylic acid is not a substrate of P-gp.
Neovascularization in carotid atherosclerotic plaques can be effectively evaluated by superb microvascular imaging (SMI): Initial experience

The objective of this study was to investigate the correlation between the amount of blood flow in the area of neovascularization within a carotid atherosclerotic plaque by superb microvascular imaging (SMI) and the microvessel density (MVD) determined by histopathological staining. Twenty-eight carotid atherosclerotic plaques were detected by SMI in 28 patients who underwent carotid endarterectomy. SMI was graded according to the visual methods as follows: grade I: no appearance of neovascularization within the plaque; grade II: punctate neovascularization; grade III: one or two linear neovascularizations within the plaque; and grade IV: multiple (> 2) linear neovascularizations throughout the plaque. The neovascularization density was determined by the CD31 complex staining method. There was a significant correlation between the density of neovascularization in histopathologic plaques and the blood flow grade found by SMI (r = 0.788, p < 0.001). A significant difference was observed in SMI blood flow grade between the symptomatic and asymptomatic groups (χ2 = 2.634, p = 0.036). The MVD of plaques in the symptomatic group was significantly higher than that in the asymptomatic group (t = 2.530, p = 0.018). The SMI-based classification was positively correlated with plaque thickness. SMI, which is a new nonultrasound contrast-enhanced imaging method, can effectively evaluate neovascularization in carotid atherosclerotic plaques and can be used as a novel method for the clinical prediction of stroke risk.
The impact of disuse and high-fat overfeeding on forearm muscle amino acid metabolism in humans.

CONTEXT Anabolic resistance is mechanistically implicated in muscle disuse atrophy. OBJECTIVE Assess whether anabolic resistance is associated with reduced postprandial amino acid uptake or exacerbated by excess lipid availability. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS Twenty men underwent 7 days of forearm immobilization while consuming a eucaloric (CON; n=11) or high-fat overfeeding (HFD; n=9; 50% excess energy as fat) diet (parallel design) within our Nutritional Physiology Research Unit. MAIN OUTCOME MEASURES Pre- and post- immobilization we measured forearm muscle cross sectional area (aCSA), and postabsorptive and postprandial (3 h post ingestion of a liquid, protein rich, mixed meal) forearm amino acid metabolism using the arterialised venous-deep venous balance method and infusions of L-[ring-2H5]phenylalanine and L-[1-13C]leucine. RESULTS Immobilization did not affect forearm muscle aCSA in either group, but tended to reduce postabsorptive phenylalanine (P=0.07) and leucine (P=0.05) net balances equivalently in CON and HFD. Mixed meal ingestion switched phenylalanine and leucine net balances from negative to positive (P<0.05), an effect blunted by immobilization (P<0.05) and to a greater extent in HFD than CON (P<0.05). Pre-immobilization, meal ingestion increased leucine rates of disappearance (Rd; P<0.05), with values peaking at 191% (from 87±38 to 254±60 µmol.min-1.100 mL forearm volume-1) and 183% (from 141±24 to 339±51 µmol.min-1.100 mL-1) above postabsorptive rates in CON and HFD, respectively, with meal induced increases not evident post-immobilization in either group (P>0.05). CONCLUSIONS Disuse impairs the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply. Moreover, disuse reduced postprandial forearm amino acid uptake; however, this is not worsened under high-fat conditions.
DAMAGE ANALYSIS METHOD FOR MULTIPLE DAMAGED ELEMENTS USING FRREQUENCY RESPONSES

This paper develops the ‘Damage Analysis Method’ to detect, locate and quantify multiple damages in civil structures. Damage extent coefficients are proposed to be used to locate and quantify damaged elements in structures altogether in one stage. They are obtained by solving a series of equations simultaneously. These equations are related to the degrees-offreedom and to the summation of the product of the changes in frequency responses and stiffness of each element. A numerical truss structure is used to test and compare the proposed method with the ‘Two-Stage Method’ presented by Guo and Li [17] for different damage cases ranging from single damage to multiple damages. The results demonstrate that the proposed method locates and quantifies damages accurately. It also allows structures with multiple damages to be analyzed with high accuracy while the Two-Stage Method cannot be performed for all multiple damages scenarios. Moreover, the method works in one stage which removes the need for manual analysis and knowledge of the geometry of the structure, which are required for the Two-Stage Method.
On Stability of Aggregation Procedures

We consider the problem of aggregation of several rankings of the same objects. For example, different decisions can be ranked by their economic influence, safety, social impact and so on. Or program committee members individually rank the papers. In all these cases we need to come to the final decision taking into account individual rankings. There are some well-known aggregation procedures that come from social choice literature like Plurality, Approval or Borda rules. While it is obvious that each ranking should influence the final decision, a high sensitivity of the rules for small changes is not a good property, for example when those changes are made by mistakes in individual rankings or by attempts of individual members to pursue more preferable result for them. We study 20 aggregation procedures and compare them according to their stability. We found that Threshold rule is the most stable one in most cases. The results can be used in developing decision support systems.
Vitamin B12 Deficiency in Metformin Treated type 2 Diabetic Patients and Factors Associated with it: A Cross-Sectional Study

Objectives: The objectives of the present study were to assess frequency of vitamin B12 deficiency in metformin treated diabetic patients and to evaluate various factors associated with B12 deficiency. Materials and Methods: This cross-sectional study involved 82 adult patients of type 2 diabetes treated with metformin for at least one year in a tertiary care government hospital. Absolute vitamin B12 deficiency was defined as ≤ 203 pg/ml, values of 203 -298 pg/ml were considered as borderline deficiency and values above >298 pg/ml as normal. Results: The mean age of study population was 60.23 ± 9.20 years. The mean daily dose of metformin was 984.7 ± 185.7 mg. About 41% patients received combination therapy with metformin and glimepiride. Multivitamin supplements were used by 37.8% patients. Absolute vitamin B12 deficiency was found in 7.31% and combined absolute plus borderline deficiency was found 34.1% patients. Age, gender, duration of diabetes, duration of metformin therapy, total daily dose of metformin, HbA1c value, use of sulfonylurea and use of H2 antihistaminics was not significantly associated with vitamin B12 deficiency. Use of multivitamin led to significant decrease in frequency of vitamin B12 deficiency (16.1% vs. 45.1%, p=0.007). Conclusion: Substantial proportion of patients receiving long term metformin show biochemical deficiency of Vitamin B12.Use of multivitamin significantly reduces likelihood of vitamin B12 deficiency.
Cooking Procedures and Storage Practices at Home on Consumer Exposure to Listeria Monocytogenes and Salmonella Due to the Consumption of Pork

The objective of this research was to analyse the impact of different cooking procedures (i.e., gas hob and traditional static oven) and levels of cooking (i.e., rare, medium and well done) on inactivation of Listeria monocytogenes and Salmonella in pork loin chops. Moreover, the consumer’s exposure to both microorganisms after simulation of meat leftover storage at home was assessed. The results showed that well-done cooking on static oven was the only treatment able to inactivate the tested pathogens. The other cooking combinations allowed to reach in the surface product temperatures always ≥ 73.6°C, decreasing both pathogens between 6 and 7 log10 cfu/g. However, according to simulation results, the few cells surviving cooking treatments can multiply during storage by consumers up to 1 log10 cfu/g, with probabilities of 0.059 (gas hob) and 0.035 (static oven) for L. monocytogenes and 0.049 (gas hob) and 0.031 (static oven) for Salmonella. The key factors affecting consumer exposure in relation to storage practices were probability of pathogens occurrence after cooking, doneness degree, time of storage and time of storage at room temperature. The results of this study can be combined with prevalence data and dose response models in risk assessment models and included in guidelines for consumers on practices to be followed to manage cooking of pork meat at home.
Unsupervised Feature Selection Based on Low-Rank Regularized Self-Representation

Feature selection aims to find a set of features that are concise and have good generalization capabilities by removing redundant, uncorrelated, and noisy features. Recently, the regularized self-representation (RSR) method was proposed for unsupervised feature selection by minimizing the L2,1 norm of residual matrix and self-representation coefficient matrix. In this paper, we find that minimizing the L2,1 norm of the self-representation coefficient matrix cannot effectively extract the features with strong correlation. Therefore, by adding the minimum constraint on the kernel norm of the self-representation coefficient matrix, a new unsupervised feature selection method named low-rank regularized self-representation (LRRSR) is proposed, which can effectively discover the overall structure of the data. Experiments show that the proposed algorithm has better performance on clustering tasks than RSR and other related algorithms.
Metabolic Syndrome in People Living with HIV in Lome (Togo): Epidemiological Aspects and Associated Factors

Introduction: People living with HIV (PLWHIV) are exposed to Metabolic Syndrome (MS), which increases their risk of having cardiovascular events and type 2 diabetes. No data on this subject is available in Togo. Objective: The objective of our study was to make an inventory of the metabolic syndrome among PLWHIV in Togo. Method: This was a prospective cross-sectional descriptive and analytical study on PLWHIV received at the day hospital of the Infectious Diseases Department of the Sylvanus Olympio University Hospital for a period of six months. Results: A total of 279 PLWHIV patients were enrolled, of which 237 (84.9%) were on Highly Active Antiretroviral Treatment (HAART) and 42 (15.1%) were naive. Metabolic syndrome has been demonstrated in 28.7% of the study population. Abdominal obesity was the most represented component of MS with a proportion of 57.7%. Risk factors associated with MS were female sex (OR = 3.01; CI: 1.52 - 5.93; p 2 (OR = 3.29; CI: 1.92 - 5.64; p 3 (OR = 1.85; CI: 1.06 - 3.20; p < 0.029), high blood pressure (OR = 13.04; CI: 6.16 - 27.62; p < 0.001). Conclusion: There is a need to screen MS for PLWHIV so that risk factors associated with it can be addressed early.
Aloe Vera: Its Uses in the Field Of Medicine and Dentistry

Use of herbal products in preventing and treating the oral and general health conditions is gaining its significance in western countries. It is attributed to its minimal side effects, highly effective treatment. It could be of benefit to low socio-economic level in urban and rural communities. Aloe vera is one of the oldest plants known to be used from thousands of years for medicinal purpose. More than 300 varieties of aloe vera exist, among them Aloe barbadensis variety exhibits excellent medicinal property. Aloe vera is called as universal panacea in Greek. In this article Aloe vera plant, its composition, properties, its clinical uses in field of Medicine and Dentistry are reviewed.
Hybrid Approach of Scheduling Using BAT&CUCKO Algorithm in Parallel System

: These days, Grid computing has increased huge consideration because of its innovative progression, cost lessening and accessibility. In the Grid situations, the appropriate scheduling of the got tasks over service gives has turned into a vital and essential issue. The scheduling issue in Grid situations is a NP-hard issue. Hence, numerous heuristics have been proposed to take care of this issue up to now. In this paper, we propose another bee colony calculation to plan the tasks on service providers in the Grid conditions. The comes about exhibited that the proposed calculation has a superior operation as far as task execution time, holding up time and missed tasks. ---------------------------------------------------------------------------------------------------------------------------------------
A Critical Appraisal of a Harm Study: Being Children of Immigrant Parents and Acquiring Attention-Deficit/Hyperactivity Disorder

Background and aims: Mental health problems are not uncommon among children of the immigrants. Recently, the immigrants' toll has increased in most developed nations. The children of immigrant parents are frequently susceptible to mental illnesses like attention-deficit/hyperactivity disorder (ADHD). The association between being diagnosed with ADHD and being children of immigrant parents is poorly understood. A study by Lehti et al. (2016) has researched such association using data from a population-based register, the Finnish Hospital Discharge Register (FHDR). This study attempts to critically appraise and evaluate the validity of the evidence of Lehti et al. (2016) study. The validity of FHDR has also been discussed since multiple psychiatric research are based on FHDR. Methods and Material: This critical appraisal was done using critical appraisal tool (CAT) mentioned in Glynn (2006) study which calculates overall and section validity of a research paper (by calculating validity scores). Statistical analysis: Percentage calculation for validity was done. Results and Conclusions: The study appraised here couldn’t attain overall validity, therefore according to this appraisal, future studies are required to address the knowledge gap in this pertinent area of child psychiatry. In addition, to make FHDR a better tool for psychiatric research, incorporation of codes of Diagnostic and Statistical Manual of Mental Disorders along with codes of International Classification of Diseases is highly recommended.
EFFECTS OF THE YUFUTSU BASIN ON STRUCTURAL RESPONSE DURING SUBDUCTION EARTHQUAKES

Sedimentary basins tend to increase the intensity of ground-motions and the resulting damage to structures. Although current U.S. seismic hazard maps do not account for the effects of basins, most ground-motion prediction equations for crustal earthquakes include basin amplification terms, which amplify spectral acceleration at long periods. For most subduction earthquake GMPEs, these basin terms have not yet been developed. In addition, none of the available GMPEs account for the effects of basins on ground-motion duration and spectral shape. These omissions are particularly important in the Pacific Northwest of the United States, because this region has several deep basins, and even without considering basin effects, subduction earthquakes contribute a large portion of the overall seismic hazard, particularly at long periods. This paper quantifies the effects of the Yufutsu basin in Japan, which is similar to the deep basin underlying the Seattle region. For several subduction earthquakes of varying magnitude, the effects of basins are evaluated by comparing ground-motion recordings from stations located inside and near the Yufutsu basin. Basin effects are quantified using spectral acceleration, significant duration, and a new ductility dependent spectral shape intensity measure, SSa. The results of collapse analyses are reported for a set of well-studied archetypical building frame models, for which the ground-motion intensity at collapse is explained in terms of the three intensity measures. Finally, design strength amplification factors are developed with the aim of achieving collapse margin ratio for structures located inside basins during subduction earthquakes that are similar to those achieved by conventional structural designs.