Miracle-dz/UniFAR-FTUs huggingface dataset:
PENGARUH AGRESIVITAS PAJAK TERHADAP PENGUNGKAPAN CORPORATE SOCIAL RESPONSIBILITY( Studi Empiris pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia Tahun 2013–2016 )

This study aims to examine the effect of tax aggressiveness on corporate social responsibility disclosure. The dependent variable used in this study is the disclosure of social responsibility. While the independent variable in this study is the tax aggressiveness measured using the proxy Effective Tax Rates (ETR). This study uses four control variable; include capiral intensity, market to book ratio, return on asset (ROA), dan size. This study is a replication of the study by Lanis and Richardson (2013) and using 192 manufacturing companies that listed on the Indonesia Stock Exchange in the perioed 2013-2016 as the sample. The sample is chosen by purposive sampling method and there are 24 data outlier. The company that meet the criteria of this research are 168 companies. Data were analyzed using ordinary least square regression analysis model. The study indicate that tax aggressiveness has a positive and significant impact on the disclosure of Corporate Social Responsibility. The study indicate that the higher the level of tax aggressiveness of a company, the greater the disclosure of Corporate Social Responsibility. So this study justify the theory of legitimacy.
Akt-Dependent Phosphorylation Specifically Regulates Cot Induction of NF-κB-Dependent Transcription

ABSTRACT The Akt (or protein kinase B) and Cot (or Tpl-2) serine/threonine kinases are associated with cellular transformation. These kinases have also been implicated in the induction of NF-κB-dependent transcription. As a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, Cot can also activate MAP kinase signaling pathways that target AP-1 and NFAT family transcription factors. Here we show that Akt and Cot physically associate and functionally cooperate. Akt appears to function upstream of Cot, as Akt can enhance Cot induction of NF-κB-dependent transcription, and dominant-negative Cot blocks the activation of this element by Akt. Furthermore, deletion analysis shows that binding to Akt is critical for Cot function. The regulation of NF-κB-dependent transcription by Cot requires Akt-dependent phosphorylation of serine 400 (S400), near the carboxy terminus of Cot. However, phosphorylation at this site is not required for Cot kinase activity or AP-1 induction, suggesting it specifically regulates Cot effector function at the level of the NF-κB pathway. Mutation of S400 in Cot does indeed abolish its ability to activate IκB-kinase (IKK) complexes, but paradoxically it allows for increased Cot association with the IKK complex. This mutated form of Cot also acts as a dominant negative for T-cell antigen receptor/CD28- or Akt/phorbol myristate acetate-induced NF-κB induction, while having relatively little effect on tumor necrosis factor induction of NF-κB. These findings suggest that the activation of different signaling pathways by MAP3Ks may be regulated separately and may provide evidence for how such discrimination by one member of this kinase family occurs.
Improving the Operation of Text Categorization Systems with Selecting Proper Features Based on PSO-LA

With the explosive growth in amount of information, it is highly required to utilize tools and methods in order to search, filter and manage resources. One of the major problems in text classification relates to the high dimensional feature spaces. Therefore, the main goal of text classification is to reduce the dimensionality of features space. There are many feature selection methods. However, only a few methods are utilized for huge text classification problems. In this paper, we propose a new wrapper method based on Particle Swarm Optimization (PSO) algorithm and Support Vector Machine (SVM). We combine it with Learning Automata in order to make it more efficient. This helps to select better features using the reward and penalty system of automata. To evaluate the efficiency of the proposed method, we compare it with a method which selects features based on Genetic Algorithm over the Reuters-21578 dataset. The simulation results show that our proposed algorithm works more efficiently.
Novel parallel join algorithms for grid files

The present advances in parallel and distributed processing and its application to database operations such as join resulted in investigating parallel algorithms. Hash based join algorithms involve a costly data partitioning phase prior to the join operation. This paper presents new parallel join algorithms for relations based on grid files where no costly partitioning phase is involved, hence the performance can improve.
Multilocus sequence typing of Neisseria meningitidis directly from cerebrospinal fluid

MLST typing of Neisseria meningitidis directly from clinical material was introduced in the National Reference Laboratory for Meningococcal Infections in Prague. Four cerebrospinal fluid samples were obtained from patients with suspected meningococcal invasive disease. In all samples, all classical laboratory methods gave negative results and the only positive method was PCR, which revealed Neisseria meningitidis group C (two specimens) and group B (two specimens), respectively. MLST performed directly from cerebrospinal fluid revealed that the strains causing the two group C infections were of sequence type (ST) 11, while the two group B infections were characterized as ST-32 and ST-33 respectively. Multi-locus sequence typing of meningococci directly from clinical material offers the opportunity to improve further the surveillance of meningococcal disease and has now been introduced into the routine portfolio of tests employed at the national reference laboratory of the Czech Republic.
Tumorigenesis and Neoplastic Progression Expression of CD 74 , the Receptor for Macrophage Migration Inhibitory Factor , in Non-Small Cell Lung Cancer

Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine that is overexpressed in lung cancer. The MIF receptor was recently discovered and found to be the invariant chain of the HLA class II molecule, CD74. We hypothesized that the expression of this receptor-ligand pair in lung cancer is associated with the angiogenic activity and level of CXC chemokine expression in human specimens of non-small cell lung cancer. We, therefore, performed immunolocalization of CD74 and compared it with the localization of MIF in non-small cell lung cancer to determine their respective locations, as well as the relationship between the co-expression of MIF-CD74 and angiogenic CXC chemokines with tumor angiogenesis. We found intense CD74 expression by immunohistochemistry in 57 of 70 tumors with minimal to no staining in the remaining 13 tumors. Comparing the localization of CD74 with its putative ligand, MIF, we found that CD74 and MIF were co-expressed in tumors in close proximity, and that co-expression of the MIF-CD74 pair was associated with both higher levels of tumor-associated angiogenic CXC chemokines (ie, the ELR score) and greater vascularity compared with tumors in which MIF-CD74 co-expression was not present. We also found that MIF induced angiogenic CXC chemokine expression in an autocrine manner in vitro , a function that was specifically inhibited by antibodies to CD74. (Am J Pathol 2009, 174:638–646; DOI: 10.2353/ajpath.2009.080463)
Temporal Relation Between Myocardial Fibrosis and Heart Failure With Preserved Ejection Fraction: Association With Baseline Disease Severity and Subsequent Outcome

Importance Among myriad changes occurring during the evolution of heart failure with preserved ejection fraction (HFpEF), cardiomyocyte–extracellular matrix interactions from excess collagen may affect microvascular, mechanical, and electrical function. Objective To investigate whether myocardial fibrosis (MF) is similarly prevalent both in those with HFpEF and those at risk for HFpEF, similarly associating with disease severity and outcomes. Design, Setting, and Participants Observational cohort study from June 1, 2010, to September 17, 2015, with follow-up until December 14, 2015, at a cardiovascular magnetic resonance (CMR) center serving an integrated health system. Consecutive patients with preserved systolic function referred for CMR were eligible. Cardiovascular magnetic resonance was used to exclude patients with cardiac amyloidosis (n = 19). Exposures Myocardial fibrosis quantified by extracellular volume (ECV) CMR measures. Main Outcome and Measures Baseline BNP; subsequent hospitalization for heart failure or death. Results Of 1174 patients identified (537 [46%] female; median [interquartile range {IQR}] age, 56 [44-66] years), 250 were “at risk” for HFpEF given elevated brain-type natriuretic peptide (BNP) level; 160 had HFpEF by documented clinical diagnosis, and 745 did not have HFpEF. Patients either at risk for HFpEF or with HFpEF demonstrated similarly higher prevalence/extent of MF and worse prognosis compared with patients with no HFpEF. Among those at risk for HFpEF or with HFpEF, the actual diagnosis of HFpEF was not associated with significant differences in MF (median ECV, 28.2%; IQR, 26.2%-30.7% vs 28.3%; IQR, 25.5%-31.4%; P = .60) or prognosis (log-rank 0.8; P = .38). Over a median of 1.9 years, 61 patients at risk for HFpEF or with HFpEF experienced adverse events (19 hospitalization for heart failure, 48 deaths, 6 with both). In those with HFpEF, ECV was associated with baseline log BNP (disease severity surrogate) in multivariable linear regression models, and was associated with outcomes in multivariable Cox regression models (eg, hazard ratio 1.75 per 5% increase in ECV, 95% CI, 1.25-2.45; P = .001 in stepwise model) whether grouped with patients at risk for HFpEF or not. Conclusions and Relevance Among myriad changes occurring during the apparent evolution of HFpEF where elevated BNP is prevalent, MF was similarly prevalent in those with or at risk for HFpEF. Conceivably, MF might precede clinical HFpEF diagnosis. Regardless, MF was associated with disease severity (ie, BNP) and outcomes. Whether cells and secretomes mediating MF represent therapeutic targets in HFpEF warrants further evaluation.
Studies of vitamin A metabolism in mouse model systems

Over the past several years, discoveries from mouse genetics have had direct impact on our understanding of vitamin A metabolism. Although the metabolism of vitamin A in the mouse does have some special features (for example very large stores of liver and pulmonary retinyl esters), the ability to construct knockout and transgenic mouse models has yielded an impressive amount of information directly relevant to understanding the general principles of vitamin A transport, storage and degradation. We discuss below the metabolism of vitamin A through a number of genetically engineered mouse strains with alterations in genes that affect this metabolism. The novelty of this experimental approach is evidenced by the fact that the oldest of these strains was first reported only eight years ago. 1 ) BioEssays 23:409–419, 2001. © 2001 John Wiley & Sons, Inc.
Smart backhauling subsystem for 5G heterogeneous network

Backhaul is one of the most important part of mobile network that cause a lot of limitations in terms of performance. In this paper, we propose new backhauling subsystem basic on MIMO technology that provides intelligent resource reallocation according to current load conditions. We provide a deep study of the network performance on the physical layer. Our results show that our backhaul subsystem can provide up to 30 times higher throughput while maintaining reasonable BER and transmission power.
Assay of coenzyme Q(10) in plasma by a single dilution step.

A new method is described for determining coenzyme Q(10) (CoQ(10)) in plasma. The method is based on oxidation of CoQ(10) in the sample by treating it with para-benzoquinone followed by extraction with 1-propanol and direct injection into the HPLC apparatus. This method achieves a linear detector response for peak area measurements over the concentration range of 0.05-3.47 microM. Diode array analysis of the peak was consistent with CoQ(10) spectrum. Supplementation of the samples with known amounts of CoQ(10) yielded a quantitative recovery of 96-98.5%; the method showed a level of quantitation of 1.23 nmol per HPLC injection (200 microl of propanol extract containing 33.3 microl of plasma). A correlation of r = 0.99 (P < 0.0001) was found with a reference electrochemical detection method. Within run precision showed a CV% of 1.6 for samples approaching normal values (1.02 microM). Day-to-day precision was also close to 2%.
Protein Synthesis during Endogenous Rhythmic Leaflet Movement in Albizzia

A rhythm was found in protein synthesis accompanying rhythmic leaflet opening and closing in the dark in the plant Albizzia. More protein was synthesized during the opening of the leaflets than during the closing. Furthermore, an inhibitor of protein synthesis, cycloheximide, prevented rhythmic opening of leaflets but had no effect on rhythmic closing. It is suggested that protein synthesis is involved in the movement across membranes of K+ ions that cause turgor changes and leaflet movement.
Stability and stabilisation of active ladder circuits modeled in the form of two-dimensional (2D) systems

Electrical ladder circuits can be considered as spatially interconnected systems of regular structure and can be viewed in the form of two dimensional (2D) systems, where one of the indeterminates is time and another is the number of subsystem in the overall structure. In this paper we develop a new 2D system based method of its stability analysis and stabilizing controller design with the use of Linear Matrix Inequalities (LMI) techniques.
FACTORS AFFECTING ADOPTION OF INNOVATIONS BY DAIRY PRODUCERS IN INDIA

A study was conducted in Bangalore rural district of Karnataka, India with the objective to analyze the various factors affecting adoption of innovations by dairy farmers as well as their relation with the rate of adoption. Primary data were collected from 180 farmers using random sampling method. A semi structured interview schedule was used to collect the data, by personal interviews. Herd size, occupation, and social participation are positively correlated with the adoption; family education level of the respondent is highly positively correlated with adoption, whereas farm size is negatively correlated. The results show that the majority of livestock owners had a medium level of adoption behavior with respect to dairy farming innovations. Information, farmer to farmer communication, farmer-researcher communication, farmer-extension agent communication, availability of inputs and overall knowledge level about dairy technologies have a positive and highly significant relationship with the overall adoption of dairy innovations by livestock owners. The communication among farmers, scientists, extension agents and other stakeholders has to be strengthened, for favoring a faster adoption of appropriate technologies.
Vocational rehabilitation policies and programmes: what can we learn from other countries?

This paper attempts to address the issue of what, if anything, can be learnt by comparing the vocational rehabilitation outcomes achieved by different countries. We shall focus on just two European countries – the United Kingdom and Germany – but, before doing so, we shall briefly examine work carried out by some American and European researchers and by the International Social Security Association.
Entrepreneurial Crowdfunding without Private Claims

For a wide class of crowdfunding approaches, we argue that the reward structure (for funders) is closer to that of charitable donations to public goods than it is to traditional entrepreneurial finance. Many features of the design of crowdfunding platforms can therefore be understood as attempts to deal with attendant “free-rider” problems in motivating contributions. Reviewing institutional features of today’s crowdfunding, we clarify that there are often limits in the extent to which tangible rewards can be used to motivate contributions. Drawing on analogies with charitable donations, we theorize that intangible sources of motivation — (i) direct psychological rewards, (ii) reciprocity and (iii) social interactions — can play a role in entrepreneurial crowdfunding. In our detailed empirical analysis of a representative project we find abundant evidence consistent with this characterization and we proceed to discuss implications for platform design and entrepreneurial funding and unique and defining characteristics of crowdfunding.
Organic Marketing Features Fresh Foods and Direct Exchange

A fter struggling to build market recognition and supply capacity for many years, the organic farming industry is now one of the fastest growing segments of U.S. agriculture. USDA estimates that certified organic cropland more than doubled in the United States between 1992 and 1997, and two organic livestock sectors-eggs and dairy-grew even faster. Recent data suggest that this momentum continued or accelerated in 1998 and 1999. While processed foods made with organic ingredients and sold through national distributors account for much of this growth, fresh vegetables, milk, and other perishables marketed directly to consumers, chefs, and retailers are still a major focus of this sector. Sales of organic products through natural food stores, direct markets, conventional grocery stores, and exports more than doubled between 1992 and 1996, to $3.5 billion, according to industry data, mirroring the growth in acreage during this period. Exports accounted for about 5 percent of sales during this period and are currently under 5 percent. More recent industry data on organic sales through natural food stores, the largest outlet for
Solution against BGP vulnerabilities

: The Border Gateway Protocol (BGP) is the only inter-domain routing protocol.Routing information among Autonomous Systems (AS) is exchanged using BGP. BGP protocol does not provide any security mechanism, so it is weak to provide security for AS path, verification of AS number ownership as well as network prefix. Due to lack of security measures, BGP remains vulnerable to various types of misconfiguration and attacks. The objective of this paper is to introduce BGP, to present its current vulnerabilities of inter-domain routing system, to survey some proposed solution for securing BGP and also propose a solution that will overcome almost all vulnerabilities regarding BGP. We use x.509 certificates for authentication of address space and BGP speaker. IPsec is also applied for creating secure communication between BGP speakers.In our proposal, we first authenticate BGP speaker after verifying its certificate, if the certificate is valid then only BGP session is established. In our analysis we found that our proposed solution has very low computational cost, reduction of memory requirement at BGP speaker in comparison to other proposals.
Anticipated Ethics and Regulatory Challenges in PCORnet: The National Patient-Centered Clinical Research Network

ABSTRACT PCORnet, the National Patient-Centered Clinical Research Network, seeks to establish a robust national health data network for patient-centered comparative effectiveness research. This article reports the results of a PCORnet survey designed to identify the ethics and regulatory challenges anticipated in network implementation. A 12-item online survey was developed by leadership of the PCORnet Ethics and Regulatory Task Force; responses were collected from the 29 PCORnet networks. The most pressing ethics issues identified related to informed consent, patient engagement, privacy and confidentiality, and data sharing. High priority regulatory issues included IRB coordination, privacy and confidentiality, informed consent, and data sharing. Over 150 IRBs and five different approaches to managing multisite IRB review were identified within PCORnet. Further empirical and scholarly work, as well as practical and policy guidance, is essential if important initiatives that rely on comparative effectiveness research are to move forward.
Can the neuropsychological case-study approach be applied to schizophrenia?

SYNOPSIS Neuropsychological studies of schizophrenia typically apply a small number of tests to a large group of patients. This approach has at least two drawbacks. First, the heterogeneity of the condition will lead to group means which may not reflect the behaviour of any individual. Secondly, it is difficult to infer the nature of the underlying cognitive impairments from a small number of tests, since good performance on a particular test depends on many different cognitive processes. In these circumstances it is more appropriate to apply the methods of cognitive neuropsychology where a large number of tests are used on a single case. This approach has proved fruitful in the study of neurological patients. We have intensively studied 5 chronic schizophrenic patients. These patients varied greatly in terms of overall ability. However, all patients, whatever their overall ability, performed badly on tests sensitive to frontal lobe lesions. This result suggests impairment of the supervisory attentional system in these patients. In addition, one patient suffered from a visual agnosia.
Mechanisms of dyspnea in chronic lung disease

Purpose of reviewTo discuss three emerging areas of research triggering new hypotheses for mechanisms of dyspnea. Recent findingsThere has been an emphasis on the importance of lung volumes in evaluating symptoms and lung function in patients with chronic obstructive pulmonary disease. Dyspnea intensity seems to more closely correlate with measures of hyperinflation than airflow limitation, highlighting the importance of neuromechanical dissociation in the development of dyspnea. Inhaled furosemide has demonstrated a beneficial effect in laboratory-induced dyspnea, and the sensation of air hunger has been ameliorated by this therapy, possibly via activation of pulmonary stretch receptors. There appear to be distinct affective and sensory components of dyspnea, and the affective dimension may be modifiable, although this has not been fully studied. SummaryDyspnea in chronic obstructive pulmonary disease is clearly related to hyperinflation, and lung volumes are valuable for characterizing disease. It remains unclear whether a limitation in tidal volume due to dynamic hyperinflation is the key factor in exertional dyspnea in this disease. Research of inhaled furosemide demonstrates the importance of afferent sensory input in modifying dyspnea, and deserves further study. The contributions of the affective and sensory components of dyspnea remain unclear, but should be studied further.