Miracle-dz/UniFAR-FTUs huggingface dataset:
Neurons in human epileptic cortex: Correlation between unit and EEG activity

A total of 90 neurons were recorded extracellularly from 17 awake patients undergoing craniotomy for excision of epileptogenic cortex. Relationships between single‐unit activity and gross epileptiform spikes recorded locally by the microelectrode or from the immediate overlying cortical surface by electrocorticography (ECoG) were examined. Similar relationships were also sought between interictal bursts from nearby cells when action potentials from several neurons had been recorded simultaneously by the tungsten electrodes. Although 40 single units fired action potentials in some relation to ECoG spikes, the relationships were variable between units and, often, for the same unit. For many units, action potentials were more consistently related to one phase of the local field potential recorded through tungsten microelectrodes than to the ECoG recorded from the overlying cortical surface. Synchronous firing between single units recorded simultaneously by the same microelectrode was rarely seen except at the onset of an ictal event. In addition, a high degree of synchrony between unit firing and local ECoG spikes was recorded in a few patients, but these patients had frequent focal spontaneous seizures. The data imply that in human epilepsy, unlike some animal models of the disorder, relationships between surface epileptiform events and single‐unit burst firing are not easily found in interictal recordings. The data also suggest that synchrony between unit and surface events requires a high degree of synchrony among neurons within the epileptogenic focus.
Systemic Gene Delivery Expands the Repertoire of Effective Antiangiogenic Agents*

Cationic liposome-DNA complex (CLDC)-based intravenous gene delivery targets gene expression to vascular endothelial cells, macrophages and tumor cells. We used systemic gene delivery to identify anti-angiogenic gene products effective against metastatic spread in tumor-bearing mice. Specifically, CLDC-based intravenous delivery of the p53 and GM-CSF genes were each as effective as the potent antiangiogenic gene, angiostatin, in reducing both tumor metastasis and tumor angiogenesis. Combined delivery of these genes did not increase anti-tumor activity, further suggesting that each gene appeared to produce its antimetastatic activity through a common antiangiogenic pathway. CLDC-based intravenous delivery of the human wild type p53 gene transfected up to 80% of tumor cells metastatic to lung. Furthermore, it specifically induced the expression of the potent antiangiogenic gene, thrombospondin-1, indicating that p53 gene delivery in vivo may inhibit angiogenesis by inducing endogenous thrombospondin-1 expression. CLDC-based delivery also identified a novel anti-tumor activity for the metastasis suppressor gene CC3. Thus, CLDC-based intravenous gene delivery can produce systemic antiangiogenic gene therapy using a variety of different genes and may be used to assess potential synergy of combined anti-tumor gene delivery and to identify novel activities for existing anti-tumor genes.
Environnement informé sémantiquement enrichi pour la simulation multi-agents : application à la simulation en environnement virtuel 3D. (Semantically enriched informed environment for multi-agent simulation : application to simulation in 3D virtual environment)

La these defendue dans ce manuscrit s'interesse a la simulation multi-agents appliquee a la simulation d'individus dans des bâtiments 3D virtuels.Pour ce faire, nos travaux proposent de capitaliser l'experience acquise dans le domaine du web semantique sur les ontologies et les moteurs d'inference associes pour faciliter la conception et le developpement de comportements intelligents pour des agents evoluant dans des univers virtuels.L'objectif est de fournir aux agents une approche generique pour gerer leur representation du monde et raisonner sur cette representation.Pour cela, la problematique centrale repose sur la definition d'une ontologie decidable modelisant l'ensemble des connaissances contenues dans l'environnement virtuel 3D pour enrichir semantiquement l'environnement d'une simulation multi-agents.Cette ontologie decidable a pour but d'offrir la possibilite d'integrer les moteurs d'inference semantique au c\oe{}ur de la modelisation de comportements d'agents mobiles dans un environnement virtuel.
Construction for antimagic generalized web graphs

An antimagic labeling of a graph with q edges is a bijection from the set of edges to the set of integers {1, 2, . , q} such that all vertex weights are pairwise distinct, where the vertex weight is the sum of labels of all edges incident with the vertex. Let [n] = {1, 2, . , n}. A completely separating system on [n] is a collection C of subsets of [n] in which, for each pair a = b ∈ [n], there exist A, B ∈ C such that a ∈ A, b / ∈ A and b ∈ B, a / ∈ B. Recently, a relationship between completely separating systems and labeling of graphs has been shown to exist. Based on this relationship, antimagic labelings of various graphs have been constructed. In this paper, we extend our method to produce more general results for generalized web graphs.
State feedback control of T-shaped pedestrian channel

Pedestrians evacuation is key to improve the traffic efficiency and guarantee the safety of pedestrians in high density area, which have been widely concerned by scholars. This paper establishes a macroscopic model for T-shaped channel consisting of some corridors and nodes, which is very common in real traffic system. Then, with the goal of avoiding congestion and maximizing the pedestrian flow of the whole model, a feedback controller is designed and the stability of the system is analyzed. Finally, the stability range is obtained and the simulation result is given to show the efficiency of the controller.
Técnicas para la mejora del join paralelo y del procesamiento de secuencias temporales de datos.

A continuacion se presenta la Tesis doctoral que lleva por titulo Tecnicas para la mejora del join paralelo y del procesamiento de secuencias temporales de datos, llevada a cabo por Josep Aguilar Saborit y dirigida por el profesor Josep.L Larriba-Pey. Los Sistemas Gestores de Bases de Datos (SGBDs) son las herramientas con las que se gestiona la informacion almacenada en una Base de Datos, ya sea para realizar consultas, actualizaciones o modificaciones. Los SGBDs se han convertido en una importante fuente de investigacion y desarrollo encaminada a encontrar nuevas tecnicas que hagan de los mismos unas herramientas lo mas eficientes posible. Dentro del algebra relacional, la operacion mas compleja y costosa de llevar a cabo por un SGBD, es la operacion de join. Los metodos mas conocidos y extendidos en la literatura para una ejecucion rapida y eficaz de esta operacion, son: Merge Sort Join, Nested Loop Join, Hash Join. Las dos primeras, para una ejecucion eficiente, requieren de un cierto orden en los datos de sus relaciones fuente. Esto implica una ordenacion previa o bien el soporte de una estructura auxiliar que de por si mantenga el orden de dichos datos. Por el contrario, la operacion Hash Join no precisa de ningun orden sobre las relaciones fuente y utiliza hashing sobre los datos para resolver el join. Hash Join es una de las operaciones mas utilizadas por los SGBDs y ha sido un importante foco de investigacion con el fin de explotar al maximo sus posibilidades. Esta Tesis presenta cinco tenicas. Cuatro de ellas estan destinadas a mejorar el rendimiento de la operacion de join en SGBDs paralelos, tanto en configuraciones paralelas con recursos compartidos, como en configuraciones paralelas sin recursos compartidos. La ultima tecnica, y que abarca un denso capitulo de la Tesis, presenta nuevas estructuras para representar de forma eficiente en espacio y tiempo secuencias temporales de datos. Todas las tecnicas presentadas han sido publicadas. Los respectivos articulos tambien se adjuntan al final de esta documentacion. Las referencias a dichos articulos se pueden consultar en el ultimo apendice de la Tesis.
Mortality, cardiac vagal control and physical training — what's the link?

There is little doubt that regular exercise results in increases in life expectancy and protects against adverse cardiac events in both healthy subjects and patients with cardiovascular disease. The mechanism of action of physical training remains unclear but a variety of evidence points towards an enhancement in cardiac vagal activity protecting against lethal arrhythmias. Just how physical training increases cardiac vagal activity is an area that is ill understood but plausible mechanisms include mediation via angiotensin II or NO. Further research is needed in this area. Exercise training is demanding and difficult, particularly for patients with cardiac disease. If the mechanism of increase in cardiac vagal activity with training can be determined it may be possible to use pharmacological approaches to mimic the effects of exercise with potentially beneficial effects.
Histologic evidence of new collagen formation using a Q‐switched Nd:YAG laser in periorbital rhytids

Objectives: Non‐ablative laser treatment has been used for improving dermal toning. Laser application to dermis causes new collagen formation in terms of wound healing. We aimed to study mainly histological changes in skin after the use of a Q‐switched Nd:YAG laser in non‐ablative treatment of wrinkles. Methods: The laser was adjusted to a fluency of 7 J/cm2 with a spot size of 3 mm and a pulse rate of 10 Hz to treat periorbital wrinkled areas. None of the patients had received filling materials, botulinum toxin injections or any dermabrasion procedures. All laser sessions were held every 15 days for a total of six sessions and all patients were photographed before treatment and then 2 months after the last treatment. Histological examinations were performed before laser treatment and 1 month after the final treatment. Results: Four of eight individuals showed clinical improvement. The histological proportion of collagen fibers was measured by using the Samba method. An increase in the mean optical densities (MOD) of collagen fibers compared with baselines was statistically significant in all patients (p<0.05). Conclusion: The 1064‐nm Q‐switched Nd:YAG lasers appear to be safe and efficient for non‐ablative remodeling of periorbital wrinkles.
The CDC Traumatic Brain Injury Surveillance System: Characteristics of Persons Aged 65 Years and Older Hospitalized With a TBI

ObjectiveTo examine the epidemiologic and clinical characteristics of older persons (ie, those aged 65–74, 75–84, and ≥ 85 years) hospitalized with traumatic brain injury (TBI). MethodsData from the 1999 CDC 15-state TBI surveillance system were analyzed. ResultsIn 1999, there were 17,657 persons 65 years and older hospitalized with TBI in the 15 states for an age-adjusted rate of 155.9 per 100,000 population. Rates among persons aged 65 years or older increased with age and were higher for males. Most TBIs resulted from fall- or motor vehicle (MV)-traffic-related incidents. Most older persons with TBI had an initial TBI severity of mild (73.4%); however, the proportions of both moderate and severe disability for those discharged alive and of in-hospital mortality were relatively high (23.5%, 9.7%, and 12%, respectively). Persons who fell were also more likely to have had 3 or more comorbid conditions than were those who sustained a TBI from an MV-traffic incident. ConclusionsTBI is a substantial public health problem among older persons. As the population of older persons continues to increase in the United States, the need to design and implement proven and cost-effective prevention measures that focus on the leading causes of TBI (unintentional falls and MV-traffic incidents) becomes more urgent.
Evolutionary persistence of spongy myocardium in humans.

A15-year-old boy underwent successful cardiac transplantation for severe congestive heart failure. His sister had died at the age of 9 years of undefined congenital heart disease. At the age of 10 years, during a school medical screening, the patient was diagnosed with a cardiomyopathy. At cardiac catheterization, the right ventricle disclosed an increased trabecular pattern, …
Algorithms for the Detection of Defects in GUI Applications

Problem statement: Developing software using graphical interfaces has grown rapidly in recent years. Products developed by, using GUI have to be tested for the reliability and quality of the software. The objective of software testing is to reveal all the errors in the desired software with minimum cost. GUI application comprises of several controls for user interaction and each control has several properties assigned to it. Even though default attributes and actions are available for the controls, some performance problems exist, which are undetected. Approach: The VBCT tool is developed to extract the incorrect statements in the code and various algorithms are written for detecting the logical errors in the GUI Applications. Results: This study addresses the errors in the visual applications and alerts the developer to modify the source code. This study performs structural and behavioral testing for GUI based applications. Conclusion: Identifying and removing the undetected logical errors in GUI based applications has been developed. Both white box and black box testing is attempted. The written test scripts, work in a robust manner to detect the faults.
Analysis of Lung Microbiota in Bronchoalveolar Lavage, Protected Brush and Sputum Samples from Subjects with Mild-To-Moderate Cystic Fibrosis Lung Disease

Individuals with cystic fibrosis (CF) often acquire chronic lung infections that lead to irreversible damage. We sought to examine regional variation in the microbial communities in the lungs of individuals with mild-to-moderate CF lung disease, to examine the relationship between the local microbiota and local damage, and to determine the relationships between microbiota in samples taken directly from the lung and the microbiota in spontaneously expectorated sputum. In this initial study, nine stable, adult CF patients with an FEV1>50% underwent regional sampling of different lobes of the right lung by bronchoalveolar lavage (BAL) and protected brush (PB) sampling of mucus plugs. Sputum samples were obtained from six of the nine subjects immediately prior to the procedure. Microbial community analysis was performed on DNA extracted from these samples and the extent of damage in each lobe was quantified from a recent CT scan. The extent of damage observed in regions of the right lung did not correlate with specific microbial genera, levels of community diversity or composition, or bacterial genome copies per ml of BAL fluid. In all subjects, BAL fluid from different regions of the lung contained similar microbial communities. In eight out of nine subjects, PB samples from different regions of the lung were also similar in microbial community composition, and were similar to microbial communities in BAL fluid from the same lobe. Microbial communities in PB samples were more diverse than those in BAL samples, suggesting enrichment of some taxa in mucus plugs. To our knowledge, this study is the first to examine the microbiota in different regions of the CF lung in clinically stable individuals with mild-to-moderate CF-related lung disease.
Skin repair and scar formation: the central role of TGF-β

Wound healing is a complex process that we have only recently begun to understand. Central to wound repair is transforming growth factor β (TGF-β), a cytokine secreted by several different cell types involved in healing. TGF-β has diverse effects, depending upon the tissue studied. This review focuses on healing in skin, particularly the phases of cutaneous wound repair and the role of TGF-β in normal and impaired wound-healing models. It also explores TGF-β activity in scarless foetal wound healing. Knowledge of TGF-β function in scarless repair is critical to improving healing in clinical scenarios, such as diabetic wounds and hypertrophic scars.
Living organ donation: the effect of message frame on an altruistic behaviour

Objective: This experimental study investigates the impact of message frame and risk perceptions upon willingness to consider living organ donation. Design: A 2 (gain vs. loss) by 2 (liver vs. kidney) by 2 (involved vs. not involved) between-group study was conducted. Method: Eighty-seven participants completed a questionnaire after reading a vignette designed to invite participants to consider living kidney or liver donation. Results: Within a gain frame scenario, willingness to donate was significantly higher when the risk of donating was lower. Conclusion: The results have important implications for the generalizability of framing theories and the promotion of living organ donation.
Aqueous Humor Concentrations of Topically Administered Caspofungin in Rabbits

Background: The echinocandin caspofungin (CAS) is a novel antifungal drug with fungicidal in vitro activity against all Candida spp. , which are the most frequent cause of fungal keratitis. Penetration of CAS through the cornea into the aqueous humor after topical administration was investigated. Methods: A CAS solution with a concentration of 7 mg/ml was applied onto each rabbit’s cornea. Drug application after corneal epithelium abrasion was processed in different time intervals: single application with aqueous humor sampling after 1 and 2 h. In addition, after continuous application of CAS every 30 min, aqueous humor concentrations of CAS after 1, 2 and 5 h were analyzed by liquid-chromatography tandem mass spectrometry. Results: Topical administration of CAS without corneal epithelium abrasion resulted in no detectable amounts of the drug in the aqueous humor. However, with corneal abrasion, after a single application, levels of 2.16 ± 1.57 μg/ml (n = 6) were reached after 1 h and then decreased to 1.76 ± 0.88 μg/ml (n = 2) after 2 h. After serial application every 30 min, the following intracameral levels of CAS were detected: after 1 h, 2.11 ± 1.09 μg/ml (n = 6); after 2 h, 4.94 ± 1.80 μg/ml (n = 5), and after 5 h, 3.45 ± 2.11 μg/ml (n = 6). Conclusion: In the aqueous humor, therapeutic drug levels can be reached that cover the MICs of most fungi after epithelial abrasion. To achieve a sustained high level of CAS as an effective antifungal therapy for corneal keratitis, CAS should be administered topically every 30 min after removal of the corneal epithelium.
STATIC: A Problem-Space Compiler for PRODIGY

Explanation-Based Learning (EBL) can be used to significantly speed up problem solving. Is there sufficient structure in the definition of a problem space to enable a static analyzer, using EBL-style optimizations, to speed up problem solving without utilizing training examples? If so, will such an analyzer run in reasonable time? This paper demonstrates that for a wide range of problem spaces the answer to both questions is "yes. " The STATIC program speeds up problem solving for the PRODIGY problem solver without utilizing training examples. In Minton's problem spaces [1988], STATIC acquires control knowledge from twenty six to seventy seven times faster, and speeds up PRODIGY up to three times as much as PRODIGY/EBL. This paper presents STATIC's algorithms, derives a condition under which STATIC is guaranteed to achieve polynomial-time problem solving, and contrasts STATIC with PRODIGY/EBL.
Effectiveness of biologic DMARDs in monotherapy versus in combination with synthetic DMARDs in rheumatoid arthritis: data from the Swiss Clinical Quality Management Registry.

OBJECTIVES To determine the frequency of use of biologic DMARDs (bDMARDs) in monotherapy, to describe the baseline characteristics of patients treated with bDMARDs in monotherapy and to compare the effectiveness of bDMARDs in monotherapy with that of bDMARDs in combination with synthetic DMARDs (sDMARDs). METHODS Using data from the Swiss RA (SCQM-RA) registry, bDMARD treatment courses (TCs) were classified either as monotherapy or as combination therapy, depending on the presence of concomitant sDMARDs. Prescription of bDMARD monotherapy was analysed using logistic regression. bDMARD retention was analysed using Kaplan-Meier and Cox models with the addition of time-varying covariate effects. Evolution of the DAS28 over time was analysed with mixed-effects models for longitudinal data. RESULTS A total of 4218 TCs on bDMARDs from 3111 patients were included, of which 1136 TCs (27%) were initiated as monotherapy. bDMARD monotherapy was preferentially prescribed to older, co-morbid patients with longer disease duration, lower BMI, more active disease and more previous bDMARDs. After adjusting for potential confounding factors, drug retention was significantly lower in monotherapy [hazard ratio 1.15 (95% CI: 1.03, 1.30)]. Other factors such as type of bDMARD and calendar year of prescription were associated with a stronger effect on drug retention. Response to treatment in terms of DAS28 evolution was also slightly but significantly less favourable in monotherapy (P = 0.04). CONCLUSION Our data suggest that bDMARD monotherapy is prescribed to more complex cases and is significantly less effective than bDMARD therapy in combination with sDMARDs, but to an extent that is clinically only marginally relevant.
Trombocitopenia: más importante que encontrarla es saber porqué se presenta

111 C on la incorporación de los autoanalizadores de hematología o contadores electrónicos de células a la mayoría de los laboratorios clínicos, que incluyen de rutina en el hemograma el recuento de plaquetas y los nuevos parámetros relacionados con ellas, el hallazgo de trombocitopenia cada vez es más frecuente [1-4]. Frente a esta situación, en todos los casos de trombocitopenia, el laboratorio clínico, antes de informar el hemograma, debe verificar el hallazgo mediante la aplicación de un protocolo interno de trabajo, y el médico, antes de tomar una conducta terapéutica, debe confirmar la veracidad del hallazgo e identificar la causa de la trombocitopenia, siempre teniendo en cuenta que similar a la anemia, la fiebre o el dolor, la trombocitopenia no es un diagnóstico sino un signo, que se expresa más en el laboratorio que en la clínica.
Uma análise dos pressupostos teóricos de três diretoras de um município do Noroeste do Paraná sobre o ensino-aprendizagem de Língua Inglesa para crianças

Neste trabalho, abordamos o processo de aquisicao do ensino de linguas de acordo com a concepcao socio-interacionista de Vygotsky, a partir de Basso (2001), Lightbown & Spada (1999), Vygotsky (1987) e Krashen (1988). Alguns topicos teoricos, tais como desenvolvimento cognitivo, desenvolvimento psicologico, dentre outros, mostram a capacidade intelectual da crianca (05 a 10 anos) para aquisicao de uma lingua estrangeira. Portanto, o objetivo deste trabalho e analisar, a partir dos saberes professorais de tres Diretoras de escolas primarias de um municipio do Noroeste do Parana, a concepcao sobre o processo de ensino-aprendizagem da Lingua Inglesa nas series iniciais do Ensino Fundamental.