Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhancement of electrical engineering education by a mentoring scheme

A mentoring scheme is carried out in our school to bring professional electrical engineers and university electrical engineering students together that takes advantage of resource of electrical engineers to mentor senior design projects. Electrical engineering design projects rely heavily on engineering experience and teamwork. Professional engineer involvement in this process can bring valuable experience to the students. Streamlining this collaborative development and introducing practical experience, is an essential training subject in electrical engineering education. Depending on the source of the design project, engineers are assigned to assist the students in concentrating on the important aspects of the project as well as in guidance on testing, development, implementation, technologies, and methodologies. This paper addresses the procedure of implementing this mentoring scheme. The positive effects of this mentoring scheme are examined and assessed through assessment and evaluation between engineers and students. The results reveal that this scheme significantly enhances design project in terms of student communication and coordination as well as project implementation with guidance and mentoring by professional electrical engineers.
Phase I Study of the Pan-PI3K Inhibitor Buparlisib in Adult Chinese Patients with Advanced Solid Tumors.

BACKGROUND/AIM The phosphatidylinositol-3-kinase (PI3K) signaling pathway is frequently activated in cancer. Buparlisib (BKM120), an oral pan-PI3K inhibitor, inhibits proliferation of human cancer in preclinical models. Studies of buparlisib in Western and Japanese adults with advanced solid tumors established a recommended dose of 100 mg/day and showed an acceptable safety profile and evidence of efficacy. This phase I dose-escalation/expansion study aimed to establish the maximum tolerated dose (MTD) of single-agent, once daily oral buparlisib in Chinese patients with advanced solid tumors. MATERIALS AND METHODS Patients (n=32; primary tumor site: lung (n=15), breast (n=10) or head and neck (n=7); ≥2 prior lines of antineoplastic therapy (n=26)) received 80 mg (n=15) or 100 mg (n=17) daily buparlisib. RESULTS Five patients experienced dose-limiting toxicities: grade (G)3 depression (n=1), G2 hyperglycemia (n=3) and G3 hyperglycemia (n=1). Most frequent buparlisib-related adverse events were hyperglycemia (n=18; 56%), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) increase (n=9; 28%), as well as anxiety (n=6; 19%); most common buparlisib-related G3/4 adverse events: hyperglycemia (n=3; 9%), ALT and AST increase (n=2; 6%), as well as gamma-glutamyltransferase increase (n=2; 6%). Best response was stable disease (SD) in 10 patients (31%). CONCLUSION The MTD of buparlisib was declared as 100 mg/day. Safety, efficacy and pharmacokinetic data from this study were similar to those previously reported in Western and Japanese populations.
Ellipsometric Measurement of Bacterial Films at Metal-Electrolyte Interfaces

ABSTRACT Ellipsometric measurements were used to monitor the formation of a bacterial cell film on polarized metal surfaces (Al-brass and Ti). Under cathodic polarization bacterial attachment was measured from changes in the ellipsometric angles. These were fitted to an effective medium model for a nonabsorbing bacterial film with an effective refractive index (nf) of 1.38 and a thickness (df) of 160 ± 10 nm. From the optical measurements a surface coverage of 17% was estimated, in agreement with direct microscopic observations. The influence of bacteria on the formation of oxide films was monitored by ellipsometry following the film growth in situ. A strong inhibition of metal oxide film formation was observed, which was assigned to the decrease in oxygen concentration due to the presence of bacteria. It is shown that the irreversible adhesion of bacteria to the surface can be monitored ellipsometrically. Electrophoretic mobility is proposed as one of the factors determining bacterial attachment. The high sensitivity of ellipsometry and its usefulness for the determination of growth of interfacial bacterial films is demonstrated.
The ArcA/ArcB two‐component regulatory system of Escherichia coli is essential for Xer site‐specific recombination at psi

Two recombinases, XerC and XerD, act at the recombination sites psi and cer in plasmids pSC101 and ColE1 respectively. Recombination at these sites maintains the plasmids in a monomeric state and helps to promote stable plasmid inheritance. The accessory protein PepA acts at both psi and cer to ensure that only intramolecular recombination takes place. An additional accessory protein, ArgR, is required for recombination at cer but not at psi. Here, we demonstrate that the ArcA/ArcB two‐component regulatory system of Escherichia coli, which mediates adaptation to anaerobic growth conditions, is required for efficient recombination in vivo at psi. Phosphorylated ArcA binds to psi in vitro and increases the efficiency of recombination at this site. Binding of ArcA to psi may contribute to the formation of a higher order synaptic complex between a pair of psi sites, thus helping to ensure that recombination is intramolecular.
Socio-political view of smart grid implementation — A survey

This paper deals with smart grids and social acceptance of them and based on various studies from this field attempts to answer questions such as how the society perceives this new technology, what are the sources of an influence, and what should be done in order to achieve a smooth implementation of smart grids with as few obstacles as possible. Rather new technologies are necessary for implementation of the smart grids. These must also focus on households, since these can be considered as a part of the complete system executives. So it is important that costumers understand their role and feel their involvement as an advantage for them. The base of the success lays on better relation between all business partners with particular respect to customers. The public opinion, probably one of the most important aspects in this transition to smart grids, can be influenced by not only media and marketing strategies of the energy providers, but also by a community as a whole. Since the economy and technology as well are still the priorities, consumers and communities should also be seen as one of the most crucial parts for successful implementation of smart grids.
Women and Addiction: The Importance of Gender Issues in Substance Abuse Research

ABSTRACT Substance use was considered to be primarily a male problem, and many substance abuse studies are conducted with a predominance of male participants. However, recent substance abuse research indicates significant gender differences in the substance-related epidemiology, social factors and characteristics, biological responses, progressions to dependence, medical consequences, co-occurring psychiatric disorders, and barriers to treatment entry, retention, and completion. The epidemiology of women's drug use presents challenges separate from those raised by men's drug use. A convergence of evidence suggests that women with substance use disorders are more likely than men to face multiple barriers affecting access and entry to substance abuse treatment. Gender-specific medical problems as a result of the interplay of gender-specific drug use patterns and sex-related risk behaviors create an environment in which women are more vulnerable than men to human immunodeficiency virus. Individual characteristics and treatment approaches can differentially affect outcomes by gender. All of these differences have important clinical, treatment, and research implications.
The orchestration in 5G exchange — A multi-provider NFV framework for 5G services

The goal of the 5G Exchange project is to enable cross-domain orchestration of services over multiple administrations. The system we build allows the end-to-end integration of heterogeneous resource and service elements of a multi-vendor technology environment from multiple operators by sharing their network and compute infrastructures via NFV orchestration. We will run an industry control 5G use-case, where one of the VNFs is offered by a 3rd party solution provider as a VNFaaS. We will show i) full automation for end-to-end network service orchestration over multi-provider NFV and VNFaaS offerings with latency and high availability constraints; ii) actor-role models and business interactions and iii) how — with a feedback loop to lifecycle management — the system can adapt to changes.
ANTICATABOLIC AND ANABOLIC STRATEGIES IN CRITICAL ILLNESS: A REVIEW OF CURRENT TREATMENT MODALITIES

ABSTRACT Critically ill patients characteristically exhibit a pronounced catabolism in addition to a down-regulation of normal anabolic activity, leading to major complications from loss of body protein stores. The marked decrease in lean body mass and protein stores leads to the loss of essential structural and functional proteins required for restoring and maintaining homeostasis. The standard management of the catabolic response to injury and illness has centered on optimizing nutrient intake that modulates but does not reverse the process. Complications of ongoing catabolism therefore remain a major cause of morbidity. Addition of anticatabolic and anabolic agents that may counteract “the stress response to injury or illness” may be of significant clinical benefit. Agents currently available for clinical use, which will be described, can be divided into two groups. The first group are nutrients and nutrient metabolites, namely protein and the specific amino acids, glutamine, arginine, and branched chain amino acids, especially leucine. The second group are anabolic hormones, namely growth hormone, testosterone, and the testosterone analog oxandrolone. The pros and cons of these agents, as to their anabolic and anticatabolic value, are described.
Sphingosine 1-phosphate receptor agonists: a patent review (2010 – 2012)

Introduction: The sphingosine-1-phosphate (S1P)-driven signaling regulates fundamental biological functions, including cell proliferation, angiogenesis, endothelial cell chemotaxis, immune cell trafficking and mitogenesis. A large body of research has been focusing on the development of immunosuppressive S1P1 receptor (S1P1-R) agonist molecules. The S1P1,3 – 5-R pan-agonist fingolimod (FTY720) has been approved by the FDA for the treatment of relapsing–remitting multiple sclerosis. However, FTY720 is now contraindicated in patients with compromised cardiac function. Although the main adverse effect bradycardia has been linked to the S1P3-R activation, cardiovascular liabilities persist with more selective S1P1-R agonists that have entered clinical trials. In contrast to the S1P1-R, the therapeutic application of the S1P2 – 5-Rs remains poorly explored. Areas covered: This review provides the patent literature from 2010 to date on S1P-R agonist molecules and their relevant biological properties. Expert opinion: Limited progress has been made on agonists at S1P4,5-R subtypes, with some families of S1P5-R agonists showing promising results in animal models of age-related cognitive disorders. A discrete number of reviewed molecules are S1P1-R agonists with a promising clinical outlook in transplantation, inflammation, cancer and autoimmune settings. Further preclinical and clinical studies will determine whether the new developed S1P1-R agonists do indeed improve the safety profile of FTY720.
Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway

A key goal of developmental biology is to understand the mechanisms that coordinate organ growth. It has long been recognized that the genes that control apico-basal cell polarity also regulate tissue growth. How loss of cell polarity contributes to tissue overgrowth has been the subject of much speculation. Do loss-of-function mutations in cell polarity regulators result in secondary effects that globally deregulate cell proliferation, or do these genes specifically control growth pathways? Three recent papers have shown that the apico-basal polarity determinants Lgl/aPKC and Crb regulate tissue growth independently of their roles in cell polarity and coordinately regulate cell proliferation and cell death via the Salvador/Warts/Hippo (SWH) pathway. Lgl/aPKC are required for the correct localization of Hippo (Hpo)/Ras associated factor (RASSF), whilst Crb regulates the levels and localization of Expanded (Ex), indicating that cell polarity determinants modify SWH pathway activity by distinct mechanisms. Here, we review the key data that support these conclusions, highlight remaining questions and speculate on the underlying mechanisms by which the cell polarity complexes interact with the SWH pathway. Understanding the interactions between cell polarity regulators and the SWH pathway will improve our knowledge of how epithelial organization and tissue growth are coordinated during development and perturbed in disease states such as cancer.
The European Investment Bank: Development, Integration, Investment?

The European Investment Bank (EIB) constitutes one of the main institutional pillars upon which the European Union (EU) was built. Despite this, the institution has attracted surprisingly little research. The EIB Statutes can be boiled down to three overarching objectives that its lending would prioritize â€“ development, integration and investment â€“ but little is known about the extent to which EIB loans fulfil each objective in practice. This article breaks new ground by providing the first comprehensive qualitative and quantitative analysis of EIB loans from its origins to the end of the Cold War. To do so, lending patterns were reconstructed drawing on extensive archival work. Results show that the EIB was the first International Financial Institution to place integration and development above the alleviation of capital constraints.
Interplay between Candida albicans and the Antimicrobial Peptide Armory

ABSTRACT Antimicrobial peptides (AMPs) are key elements of innate immunity, which can directly kill multiple bacterial, viral, and fungal pathogens. The medically important fungus Candida albicans colonizes different host niches as part of the normal human microbiota. Proliferation of C. albicans is regulated through a complex balance of host immune defense mechanisms and fungal responses. Expression of AMPs against pathogenic fungi is differentially regulated and initiated by interactions of a variety of fungal pathogen-associated molecular patterns (PAMPs) with pattern recognition receptors (PRRs) on human cells. Inflammatory signaling and other environmental stimuli are also essential to control fungal proliferation and to prevent parasitism. To persist in the host, C. albicans has developed a three-phase AMP evasion strategy, including secretion of peptide effectors, AMP efflux pumps, and regulation of signaling pathways. These mechanisms prevent C. albicans from the antifungal activity of the major AMP classes, including cathelicidins, histatins, and defensins leading to a basal resistance. This minireview summarizes human AMP attack and C. albicans resistance mechanisms and current developments in the use of AMPs as antifungal agents.
Haemolysis and abnormal haemorheology in sickle cell anaemia

Although pulmonary hypertension, leg ulcers, priapism, stroke and glomerulopathy in sickle cell anaemia (SCA) result from the adverse effects of chronic haemolysis on vascular function (haemolytic phenotype), osteoneocrosis, acute chest syndrome and painful vaso‐occlusive crises are caused by abnormal vascular cell adhesion and increased blood viscosity (viscosity‐vaso‐occlusion phenotype). However, this model with two sub‐phenotypes does not take into account the haemorheological dimension. We tested the relationships between the biological parameters reflecting the haemolytic rate (haemolytic component) and red blood cell (RBC) rheological characteristics in 97 adults with SCA. No significant difference in the proportion of patients with low or high haemolytic component in the low and high blood viscosity groups was observed. The RBC elongation index (i.e. deformability) was negatively correlated with the haemolytic component. The RBC aggregates strength (i.e. RBC aggregates robustness) was negatively correlated with RBC elongation index. Sickle RBCs with high density had lower elongation index and higher aggregates strength. In conclusion, (i) the ‘haemolytic’ phenotype is characterized by decreased RBC deformability and increased RBC aggregates strength and (ii) the viscosity‐vaso‐occlusive phenotype is characterized by increased RBC deformability but not always by increased blood viscosity. α‐thalassaemia modulates the haemorheological properties but other factors seem to be involved.
Improving productivity in New Zealand's economy

New Zealand ranks highly on most indicators of well-being, but incomes are below the OECD average due to low labour productivity. Low labour productivity is only partly explained by the industry composition of the NZ economy and is primarily a consequence of sustained low multi-factor productivity growth within industries, as well as weak investment. Economic geography is an important factor in New Zealand’s poor productivity performance, as the small size and remoteness of the economy diminish its access to global markets, the scale and efficiency of domestic businesses, the level of competition, and the ability to benefit from innovation at the global frontier. Policy and institutions are generally supportive of productivity growth, but there are a number of areas where there is scope for reforms that would help offset the country’s geographical disadvantages and improve the welfare of New Zealanders over the coming decades. This includes promoting international connections, removing barriers to fixed capital investment (including taxation), accessing benefits from agglomeration by improving urban planning and infrastructure provision, enhancing competition and increasing investment in innovation and intangibles. This Working Paper relates to the 2017 OECD Economic Survey of New Zealand (www.oecd.org/eco/surveys/economic-survey-new-zealand.htm).
Stroke Mortality in Andalusia (Spain) from 1975 to 1999: Effect of Age, Birth Cohort and Period of Death

The aim of this study was to analyze stroke mortality rates in Andalusia during the period from 1975 to 1999 by studying age, cohort and period effects. Deaths due to stroke along with the corresponding population figures were divided into 11 age groups and five 5-year periods. From this, age-specific mortality rates for 15 birth cohorts were then computed. These were plotted and fitted to Poisson regression models to assess age, period and cohort effects. An exponential age effect was present for both sexes regardless of cohort or period. The rates of stroke mortality decreased significantly among both sexes in Andalusia during the study period, although in recent years, this declining trend has started to slow down, primarily in males. Age- and period-adjusted stroke mortality was greater for earlier cohorts and lower for generations born at the beginning of the 20th century.
Joint optimization of frequency allocation and user association with differentiated service in hyper-cellular networks

The existing architecture of heterogeneous networks is not energy and spectrum efficient as many lightly loaded base stations (BS) can not be turned off for coverage guarantee. To further improve energy and spectrum efficiency, a new architecture called “hyper-cellular” network has been proposed in our previous work. Under this architecture, the function of different types of BSs may not be the same, and the mechanism of user association should consider many factors, such as user mobility, traffic load distribution, and differentiated service demands, which are usually ignored in the existing studies. In addition, the spectrum allocation strategy also has great influence on the network performance. As a starting point, we explore the user association mechanism based on the differentiated service demands of the network users, and jointly optimize it with spectrum allocation, in order to maximize the network capacity with quality of service constraints. Although closed-form expression of the optimal solution can not be derived, numerical results are obtained. Our approach is shown to improve the network capacity more than four times over the baseline strategy, where the conventional user association method is adopted and all BSs use all available spectrum.
The diversity of nutritional status in cancer: new insights.

OBJECTIVE Nutritional status in cancer has been mostly biased toward undernutrition, an issue now in dispute. We aimed to characterize nutrition status, to analyze associations between nutritional and clinical/cancer-related variables, and to quantify the relative weights of nutritional and cancer-related features. METHODS The cross-sectional study included 450 nonselected cancer patients (ages 18-95 years) at referral for radiotherapy. Nutritional status assessment included recent weight changes, body mass index (BMI) categorized by World Health Organization's age/sex criteria, and Patient-Generated Subjective Global Assessment (PG-SGA; validated/specific for oncology). RESULTS BMI identified 63% as >or=25 kg/m(2) (43% overweight, 20% obese) and 4% as undernourished. PG-SGA identified 29% as undernourished and 71% as well nourished. Crossing both methods, among the 319 (71%) well-nourished patients according to PG-SGA, 75% were overweight/obese and only 25% were well nourished according to BMI. Concordance between BMI and PG-SGA was evaluated and consistency was confirmed. More aggressive/advanced stage cancers were more prevalent in deficient and excessive nutritional status: in 83% (n = 235/282) of overweight/obese patients by BMI and in 85% (n = 111/131) of undernourished patients by PG-SGA. Results required adjustment for diagnoses: greater histological aggressiveness was found in overweight/obese prostate and breast cancer; undernutrition was associated with aggressive lung, colorectal, head-neck, stomach, and esophageal cancers (p < .005). Estimates of effect size revealed that overweight/obesity was associated with advanced stage (24%), aggressive breast (10%), and prostate (9%) cancers, whereas undernutrition was associated with more aggressive lung (6%), colorectal (6%), and head-neck (6%) cancers; in both instances, age and longer disease duration were of significance. CONCLUSION Undernutrition and overweight/obesity have distinct implications and bear a negative prognosis in cancer. This study provides novel data on the prevalence of overweight/obesity and undernutrition in cancer patients and their potential role in cancer histological behavior.