Miracle-dz/UniFAR-FTUs huggingface dataset:
Defining Semantics for Data Element with Semantic Tree

Without explicit and formal semantic approach, data element is restricted in automatic data modeling and other application. The precise semantics for data element is supplied with ontology. Semantics factors of data element are analyzed at first. The concepts from domain ontology are considered as atomic concepts and are considered as semantic element concepts of data element. A structure called semantic tree was presented that the relationships among the concepts of data element, such as properties, object classes and representations, are expressed explicitly, formally and intuitionally. Supplied with constrains to semantic tree, the application data elements can be defined simply. For searching data element and mapping data model with data element automatically, the paper presents an arithmetic based on semantic tree to measure the semantic similarity between data elements is presented. Compared with others, the semantic tree has some obvious strongpoint.
Moduli space of logarithmic connections singular over a finite subset of a compact Riemann surface

Let $S$ be a finite subset of a compact connected Riemann surface $X$ of genus $g \geq 2$. Let $\cat{M}_{lc}(n,d)$ denote the moduli space of pairs $(E,D)$, where $E$ is a holomorphic vector bundle over $X$ and $D$ is a logarithmic connection on $E$ singular over $S$, with fixed residues in the centre of $\mathfrak{gl}(n,\C)$, where $n$ and $d$ are mutually corpime. Let $L$ denote a fixed line bundle with a logarithmic connection $D_L$ singular over $S$. Let $\cat{M}'_{lc}(n,d)$ and $\cat{M}_{lc}(n,L)$ be the moduli spaces parametrising all pairs $(E,D)$ such that underlying vector bundle $E$ is stable and $(\bigwedge^nE, \tilde{D}) \cong (L,D_L)$ respectively. Let $\cat{M}'_{lc}(n,L) \subset \cat{M}_{lc}(n,L)$ be the Zariski open dense subset such that the underlying vector bundle is stable. We show that there is a natural compactification of $\cat{M}'_{lc}(n,d)$ and $\cat{M}'_{lc}(n,L)$ and compute their Picard groups. We also show that $\cat{M}'_{lc}(n,L)$ and hence $\cat{M}_{lc}(n,L)$ do not have any non-constant algebraic functions but they admit non-constant holomorhic functions. We also study the Picard group and algebraic functions on the moduli space of logarithmic connections singular over $S$, with arbitrary residues.
A Globally Optimal Energy-Efficient Power Control Framework and Its Efficient Implementation in Wireless Interference Networks

This work develops a novel power control framework for energy-efficient power control in wireless networks. The proposed method is a new branch-and-bound procedure based on problem-specific bounds for energy-efficiency maximization that allow for faster convergence. This enables to find the global solution for all of the most common energy-efficient power control problems with a complexity that, although still exponential in the number of variables, is much lower than other available global optimization frameworks. Moreover, the reduced complexity of the proposed framework allows its practical implementation through the use of deep neural networks. Specifically, thanks to its reduced complexity, the proposed method can be used to train an artificial neural network to predict the optimal resource allocation. This is in contrast with other power control methods based on deep learning, which train the neural network based on suboptimal power allocations due to the large complexity that generating large training sets of optimal power allocations would have with available global optimization methods. As a benchmark, we also develop a novel first-order optimal power allocation algorithm. Numerical results show that a neural network can be trained to predict the optimal power allocation policy.
Characteristics of Thyroid Hormones in Hypertensive Hispanic Population

The aim was to characterize thyroid function in Hispanic hypertensive population. Retrospective study of 1,023 individuals was performed, in which 68.23% had hypertension (74.21% women) and 37.25% had thyroid pathology. Age, weight, blood pressure, biochemical measurements were recorded, mean age: 53.02 ± 14.80 yr, mean weight: 83.05 ± 16.95 kg, thyrotropin-stimulating hormone (TSH) hypertensive patients: 5.55 ± 1.63 µUI/mL and without hypertension: 3.72 ± 1.60 µUI/mL. TSH range concentration distributed by sex indicates: 1.50-2.49 µUI/mL men, 2.50-5.01 µUI/mL women. TSH categories vs. age were positively associated (r = + 0.114, P = 0.044) and hypertension by age was also correlated (r = + 0.178, P = 0.0001). Significant positive association we found between TSH and diastolic blood pressure (r = + 0.197, P = 0.008). Systolic and diastolic blood pressure vs. age were positively increasing (r = + 0.410, p = 0.0001; r = +0.285, P = 0.0001, respectively). Prevalence of thyroid pathology in hypertensive subjects are hyperthyroidism 5.87%; hypothyroidism 20.34% (5.73% subclinic) and autoimmune disease 6.25%. High percentage of hypertensive population has concomitant thyroid diseases, more common in women (50-70 years). Systematic surveillance for occult thyroid dysfunction in patients with hypertension could prevent future cardiovascular disease.
SEQUENCING IN PARKINSON'S DISEASE

Central programming deficits in Parkinson's disease (PD) were studied in two reaction time (RT) experiments. In Experiment 1, PD patients and controls performed sequences of hand postures that varied in length, the number of different postures (repetitive vs heterogeneous), and the delay interval before movement. Before movement, the PD group planned repetitive movements like controls whereas for heterogeneous sequences RT increased less with sequence length for the PD group, implying less preprogramming. The interresponse time (IRT) data from repetitive sequences showed that the PD group had difficulty controlling movement such that IRTs were faster when sequences were longer, thus allowing more time to schedule the termination of the sequence during the course of movement. For heterogeneous sequences, the PD group made more errors and were slower than controls when changing hand postures, suggesting a deficit in switching between different responses. While RT decreased with a longer delay similarly for both groups, IRT1, continued to improve only for the PD group but similarly for both types of sequences, suggesting a deficit specific to programming the first response. In Experiment 2, subjects made decisions about the number of different hand postures contained within a sequence. PD patients' decision times improved more with a longer delay only for heterogeneous sequences, suggesting a problem in identifying the number of different hand postures. The results have implications for levels of motor dysfunction in PD which emphasize the influence of sequence length and complexity.
Producing Hfq/Sm Proteins and sRNAs for Structural and Biophysical Studies of Ribonucleoprotein Assembly

Hfq is a bacterial RNA-binding protein that plays key roles in the post–transcriptional regulation of gene expression. Like other Sm proteins, Hfq assembles into toroidal discs that bind RNAs with varying affinities and degrees of sequence specificity. By simultaneously binding to a regulatory small RNA (sRNA) and an mRNA target, Hfq hexamers facilitate productive RNA⋯RNA interactions; the generic nature of this chaperone-like functionality makes Hfq a hub in many sRNA-based regulatory networks. That Hfq is crucial in diverse cellular pathways—including stress response, quorum sensing and biofilm formation— has motivated genetic and ‘RNAomic’ studies of its function and physiology (in vivo), as well as biochemical and structural analyses of Hfq⋯RNA interactions (in vitro). Indeed, crystallographic and bio-physical studies first established Hfq as a member of the phylogenetically-conserved Sm superfamily. Crystallography and other biophysical methodologies enable the RNA-binding properties of Hfq to be elucidated in atomic detail, but such approaches have stringent sample requirements, viz.: reconstituting and characterizing an Hfq•RNA complex requires ample quantities of well-behaved (sufficient purity, homogeneity) specimens of Hfq and RNA (sRNA, mRNA fragments, short oligoribonucleotides, or even single nucleotides). The production of such materials is covered in this Chapter, with a particular focus on recombinant Hfq proteins for crystallization experiments. Abbreviations 3D three-dimensional AU asymmetric unit CV column volume DEPC diethyl pyrocarbonate HDV hepatitis δ virus HDVD hanging-drop vapor diffusion IMAC immobilized metal affinity chromatography MW molecular weight MWCO molecular weight cut-off nt nucleotide PDB Protein Data Bank RNP ribonucleoprotein RT room temperature SDVD sitting-drop vapor diffusion Journal format Methods in Molecular Biology (Springer Protocols series); this volume is entitled “Bacterial Regulatory RNA: Methods and Protocols”; an author guide is linked at http://www.springer. com/series/7651
A Comparison of Blood Lipid Levels in Athletes in Various Branches and Sedentary University Students

This study was conducted in order to compare blood lipid levels in athletes who have been doing sports in various branches for five years or more and sedentary university students. The study covered 20 athletes, at age of 21 in average, doing sports in university teams in various branches and 20 sedentary university students - 40 in total. Having received a briefing about the tests, volunteers were measured for their physical measurements such as body height and body weight as well as their blood lipid levels. Volunteers were lectured not to take in any food or drink after 10:00 PM before the day when their blood samples would be taken. Blood samples were taken at 8:00-9:00 AM in the laboratory. Blood samples of the participating volunteers that were taken from the forearm antecubital area into 5 ml EDTA tubes in line with the hygiene rules were analyzed by means of an auto-analyzer in the central laboratory for blood lipid levels such as triglyceride, cholesterol, LDL and HDL cholesterol. The independent t-test was applied to define the differences between the groups. Level of significance was taken as 0.05. The study revealed that there was not a significant difference between the groups in terms of body height, body weight and body mass index (p>0.05) whereas the difference in cholesterol, LDL cholesterol and HDL cholesterol levels was significant (p<0.05). As a conclusion; an analysis of blood lipid levels of the participating volunteers revealed that sedentary students had higher triglyceride, cholesterol and LDL cholesterol levels whereas HDL cholesterol was higher in athletes. The study suggests that such a change in the blood lipid level relies on an exercise program that athletes regularly attend, which is supported by the findings of this study.
Evaluation of a primary care research network in rural Scotland

Primary care research networks were established in Scotland to encourage research in primary care and build capacity. The aim of this descriptive study was to evaluate the primary care research network in Dumfries and Galloway, a rural area of Scotland, by describing the methods used and the outcomes in terms of research training and completed projects. All primary care professionals working in the region were offered an initial grant to buy time for research training to develop their own research ideas. Those attending the two day research training course were encouraged to submit a protocol for funding and Local Research Ethics Committee approval. Of the 605 and 717 primary care professionals circulated in the first and second years, 23 (4%) and 11 (2%), respectively applied for a research training grant. Of these, eight completed a research project together with a further six who had previous research training. Eleven (79%) of the 14 completed projects were the subject of oral presentations and 11 were submitted for publication in peer-reviewed journals. Only a small minority of professionals working in primary care will want to develop their own research, and this requires support, protected time and long-term mentoring. Building research capacity in primary care involves a number of activities ranging from funding academic units, to giving opportunities for non-academics to undertake research. These distinctions are important for decisions about appropriate funding and support.
Mécanismes d'action et de résistance des Adénovirus C au Brincidofovir

Les adenovirus humains (HAdV) sont responsables d’une importante morbidite et mortalite chez les patients receveurs de cellules souches hematopoietiques (CSH), en particulier chez les enfants. Le brincidofovir (BCV) prodrogue du cidofovir est un analogue de la cytosine. Il inhibe l’activite de l’ADN polymerase (ADN pol) des HAdV par arret de l’elongation et competition avec les nucleotides naturels. Les objectifs de ce travail sont d’etudier la diversite genetique de l’ADN pol des HAdV et de mettre en place des outils pour l’analyse de la sensibilite des HAdV C et de resistance aux BCV. Dans une premiere partie, nous avons realise le sequencage complet du gene ADN pol de 60 souches virales cliniques. Les resultats montrent une variabilite nucleotidique de 9,9% et peptidique de 8,7%, variable en fonction du type. La region la plus variable est la region NH2 terminale avec 44,2% des mutations d’acides amines. Aucune des mutations decrites comme associees a la resistance au CDV ou au BCV n’a ete detectee. L’analyse du polymorphisme a aussi montre que les sequences ADN pol permettent d’identifier les sources de transmission au cours d’une epidemie. Enfin nos observations suggerent la faible probabilite d’evenements de recombinaison comme facteur d’evolution du gene codant pour l’ADN pol. Dans une seconde partie, nous avons developpe une strategie de genetique inverse a partir de deux plasmides, un codant pour le genome entier delete de l’ADN pol (Adv-deltaPol) et un codant uniquement pour l’ADN pol (Pol) (3 kilobase) dans lequel les mutations sont introduites par mutagenese dirigee (Pol-mute). Apres une etape de recombinaison bacterienne en un seul plasmide (Adv-deltaPol-Pol-mute), des cellules 293T sont transfectees afin de produire les virus recombinants. La susceptibilite au BCV des virus mutes sera analysee sur des cellules A549. Au total de 12 plasmides Pol-mute ont ete produits, le virus recombinant L677F a ete obtenu. Les productions des autres virus recombinants sont en cours.
Preventing CLABSIs Through a Multidisciplinary Team Effort

organization must work toward a common goal. Whether it is manning a space flight or optimizing care for patients in the intensive care unit (ICU), a strategic approach that starts with goal setting and engages the whole team in the process of achieving these goals is likely to result in success. In health care, eliminating central line–associated bloodstream infections (CLABSIs) is one such objective that will significantly affect patient care in the ICU. CLABSIs cause significant morbidity and mortality, with increased health care costs. Fortunately, the recent trend in health care has been that of near-zero tolerance toward health care–associated infections (HAIs), including CLABSIs. Regardless of whether this trend resulted from or was caused by increased vigilance by various governing agencies in health care toward these infections, evidence —“I’m helping put a man on the moon, Mr. President. ”
ROLES OF EMBLICA OFFICINALIS (AMLA) IN MEDICINE

Medicinal plants are natural gift to human lives to promote disease free healthy life. This article discuses and summarizes important medicinal values of Emblica officinalis (EO). Earlier it becomes a notable fruit for its rich amount of vitamin C, polyphenols such as tannins, gallic acid, ellagic acid, flavonoids like quercetin and rutin. Emblica officinalis (Amla) are widely distributed in tropical and subtropical areas and has therapeutic potential against deleterious diseases such as in cancer, diabetis, liver treatment, heart disease, ulcer, anemia and various other diseases. The use of EO as antioxidant, immunomodulatory, antipyretic, analgesic, cytoprotective, antitussive and gastroprotective are also reviewed. Its applications for memory enhancing, ophthalmic disorders, lowering cholesterol level are focused. The effects of EO in neutralizing snake venom and as an antimicrobial are also included.
ANTIDIABETIC EFFECT OF DIASANSAR IN STREPTOZOTOCIN AND FRUCTOSE INDUCED TYPE-2 DIABETES IN RATS

Summary Diasansar, a polyherbal formulation, was tested for its anti-diabetic activity against neonatal Streptozotocin (STZ) and fructose induced type 2 diabetes in Wistar rats. Diasansar was tested at two dose levels of 400 and 800 mg/kg, p.o. Glibenclamide (500 µg/kg, p.o.) was used as the standard. Serum glucose, lipid profile, creatinine, liver glycogen and liver weight were measured. Diasansar shows a significant antidiabetic effect at both the dose levels employed in both streptozotocin and fructose induced type 2 diabetes models. It significantly reduces the serum glucose, cholesterol, triglyceride and creatinine and significantly increases the serum HDLcholesterol, liver glycogen and absolute liver weight when compared to the untreated diabetic control (p<0.01). The results are comparable to the standard glibenclimide. In normal rats, diasansar significantly prevents the glucose load induced elevation of serum glucose levels in oral glucose tolerance test (p<0.01). The results of the present study indicate that diasansar has significant beneficial effects against streptozotocin and fructose induced hyperglycemia and hyperlipidemia in diabetic rats and on glucose tolerance in normal animals.
Control glucémico y nuevas perspectivas en la insulinoterapia en la diabetes mellitus de tipo 1

Actualmente, salvo contraindicaciones, el tratamiento de la diabetes mellitus tipo 1 (DM1) se basa en lo que conocemos por tratamiento intensivo con insulina. Esta modalidad incluye la utilizacion de insulinas de accion rapida con el fin de controlar los picos hiperglucemicos posprandiales e insulinas de accion intermedia o lenta con el objetivo de aportar unos niveles basales de insulina (terapia tipo bolo/basal). Aunque el tratamiento intensivo no evita la aparicion ni la progresion de las complicaciones microvasculares por completo, la mejora del control glucemico reduce el riesgo de desarrollar las mismas entre el 35% y el 75% aproximadamente y disminuye el riesgo su empeoramiento en un 50% y un 75%. Son muchas y obvias las ventajas que a priori presentan los nuevos analogos de insulina. Estos suponen una alternativa potencialmente eficaz en el tratamiento intensivo de los pacientes con DM1 y representan la mejor manera de implementar un esquema tipo «bolus-basal». Su aplicacion sopesada e individualizada puede contribuir a la mejora del control metabolico, incluyendo una disminucion del numero de hipoglucemias.
Synchronous Lesions in Colorectal Cancer

Purpose: The detection and removal of synchronous cancer and polyps in colorectal surgery is important to prevent the future development of metachronous cancer. However, it is occasionally impossible to evaluate the entire colon with colonoscopy preoperatively due to luminal obstruction by tumors. The aim of this study is to evaluate the incidence of synchronous colorectal tumors and to emphasize the importance of their peri-operative detection through vigorous application of colonoscopy. Methods: Three hundreds two patients underwent a potentially curative resection for colorectal cancer in Ilsan Paik Hospital from January 2000 to March 2005. Colonoscopy was performed preoperatively or intraoperatively. All the synchronous polyps detected by colonoscopy and contained in the surgical specimen were included in the analysis. The data on synchronous cancer and polyps were collected through medical records and colonoscopic databases. The incidence, the risk factors, and the effects of synchronous polyps on surgery were analyzed. Results: A total of 268 polyps were detected in 112 patients (37%) when all types of polyp were included whereas true adenomatous polyps were present in 78 patients (26%) among 302 patients. Synchronous cancers were found in 14 patients (4.6%). The detection of polyps on preoperative colonoscopy changed the surgical strategy in 30 out of the 223 patients (13.5%) who had completed preoperative colonoscopy. Neither the age and the gender of the patient, the location and the stage of the tumor, nor the family history were related with increased risk of synchronous polyps. Seventeen among 46 intraoperative colonoscopy cases had synchronous lesions which were not known on preoperative evaluation. Another bowel resection was needed to remove the lesions in nine of them. Conclusions: Synchronous colorectal polyps or cancer is frequent, and preoperative detection is important. Intraoperative colonoscopy can provide valid information if a preoperative colonoscopic evaluation is not available.
The medial temporal lobe organizes memory across time and space: Causal evidence from brain stimulation

The medial temporal lobe (MTL) is widely implicated in supporting episodic memory and navigation, but its precise functional role in organizing memory across time and space remains elusive. Here we examine the specific cognitive processes implemented by MTL structures (hippocampus and entorhinal cortex) to organize memory by using electrical brain stimulation, leveraging its ability to establish causal links between brain regions and features of behavior. We studied neurosurgical patients who performed spatial-navigation and verbal-episodic memory tasks while brain stimulation was applied in various regions during learning. During the verbal memory task, stimulation in the MTL disrupted the temporal organization of encoded memories such that items learned with stimulation tended to be recalled in a more randomized order. During the spatial task, MTL stimulation impaired subjects’ abilities to remember items using view-independent (allocentric) navigation strategies. These stimulation effects were specific to the MTL. Our findings thus provide the first causal demonstration in humans of the specific memory processes that are performed by the MTL to encode when and where events occurred. Significance Statement Numerous studies have implicated the medial temporal lobe (MTL) in encoding spatial and temporal memories, but they have not been able to causally demonstrate the nature of the cognitive processes by which this occurs in real-time. Electrical brain stimulation is able to demonstrate causal links between a brain region and a given function with high temporal precision. By examining behavior in a memory task as subjects received MTL stimulation, we provide the first causal evidence demonstrating the role of the MTL in organizing the spatial and temporal aspects of episodic memory.
Especie nueva de sanguijuela del género Semiscolex (Arhynchobdellida: Semiscolecidae) del lago de Catemaco, Veracruz, México

Semiscolex lamothei sp. nov. from Catemaco lake, Veracruz, Mexico, is described based on the examination of 18 specimens. The new species differs from other species of the genus by the presence of 1/2 + 5 + 1/2 annuli between gonopores. The new species has morphological features previously not described for any other member of the genus, such as well-developed ejaculatory bulbs and postcaeca in the posterior part of the crop. This is the fi rst record of the genus and the family in the northern hemisphere of the Americas.