Miracle-dz/UniFAR-FTUs huggingface dataset:
Ischemic Preconditioning in 18- to 20-Month-Old Gerbils

Background and Purpose—In young animals, ischemic preconditioning protects CA1 hippocampal neurons against global ischemia. However, cerebral ischemia occurs most frequently in individuals aged ≥65 years. This study examined the protection provided by ischemic preconditioning in a population of aged (18- to 20-month-old) gerbils. Methods—One group of animals was exposed to two 1.5-minute episodes of global ischemia separated by 24 hours and followed 72 hours later by a 5-minute occlusion of both carotid arteries. A second group was given 2 episodes of preconditioning only. Two other groups were exposed to 5 minutes of ischemia or sham surgery. The animals survived 10, 30, or 60 days. Functional and histological assessments were used to determine the extent of protection. Results—Ten days after ischemia there was >80% protection of CA1 neurons in ischemic preconditioned animals compared with 6% in ischemic gerbils. Nevertheless, these preconditioned animals were impaired in open-field tests of habituation.
Acute coronary syndrome in patients with cancer

ABSTRACT Introduction Improvement in cancer survival has led to an increased focus on cardiovascular disease as the other major determinant of survivorship. As a result, there has been an increasing interest in managing cardiovascular disease during and post cancer treatment. Areas covered This article reviews the current literature on the pathogenesis, risk factors, presentation, treatment and clinical outcomes of acute coronary syndrome (ACS) in patients with cancer. Expert opinion There is growing evidence that both medical therapy and invasive management of ACS improve outcomes in patients with cancer. Appropriate patient selection, risk stratification and tailored therapy represents the cornerstone of management in these patients.
Costal facet variations on the eighth, ninth and tenth thoracic vertebrae: association with sex and shifts in the cranio-caudal pattern of the human axial skeleton

Different variants of the ninth and tenth thoracic vertebrae are described in the literature with little information on their prevalence in human populations. To review this question, 5 osteological samples from different geographical areas were studied for the presence of costal facets on the eighth (T8), ninth (T9) and tenth (T10) thoracic vertebrae. We found that inferior costal facets on vertebral centrum were absent bilaterally in 1.5% of T8 and in 46% of T9; costal facets on both T10 transverse processes were absent in 39% of cases. Absence of inferior costal facets on the T8 and T9 centrum and costal facets on the T10 transverse processes was positively associated with cranial shifts at regional borders of the spine. However, additional analysis revealed that the position of the costo-central articulation at the level of T8 and T9 as well as the position of the most inferior “typical” thoracic vertebra significantly depended on sex (p<0.001). Sex differences were most pronounced at the level of T9 where females showed very frequent absence of inferior costal facets (76% of cases compared to 47% in males). This suggests a difference in an average 10th rib position in relation to the spine in females. Significant sex differences in the position of the most inferior “typical” thoracic vertebra may be partially explained by the fact that females in general are more likely to develop some forms of cranial shifts. However, according to the literature, the female axial skeleton possesses a complex of morphological features that is seen as an adaptation to pregnancy. In this view, the different position of the female 10th rib may be one component of the complex.
The effect of FIFA-11 movements on the prevention of injuries to hearing-impaired football players

The efficacy of the FIFA-11 program for preventing injuries was examined with the purpose of decreasing the injuries of hearing-impaired football players. Two teams which play in the 1 st League for the Turkish hearing-impaired, both in same group and from same geographical region, were chosen. The FIFA-11 program for the prevention of football injuries was applied on one of these teams. The second team was chosen as the control group. The control group continued its routine training throughout season. Their injury level was assessed using the Fysion Blesreg questionnaire form before and after the season. The injury incidence for the education group for 1000 hours of play was found to be 51.66, and it was found to be 92.98 for the control group. It was determined to be 17.22 for the education group and 30.99 for control group in training. Nine point four percent of the injuries received by the control group had appeared as a result of fights they had with their rivals after match. There are percentage differences between injury variations of the education group and the control group. The present study proves that regular applications such as FIFA-11 on hearingimpaired sportsmen can decrease the rate of injuries.
RESTLESS LEGS SYNDROME IN THE ELDERLY WITH OSTEOARTHRITIS

Introduction: Restless legs syndrome (RLS) is a chronic disorder characterized by abnormal sensations in the legs; seen in 10-35% of the elderly. Our objective was to determine the incidence of RLS in the elderly, and to analyze its relationship with clinical and laboratory findings. Materials and Method: Eighty-eight patients with osteoarhritis aged 65 and higher were included in this study. Patients were evaluated according to the International Restless Legs Syndrome Study Group criteria and the disease severity was rated by using the International Restless Legs Syndrome Study Group rating scale. The clinical and laboratory findings were evaluated in all patients and a detailed history was obtained. Results: The incidence of RLS was 18.2%. No significant relationship was found between RLS and the clinical and laboratory parameters evaluated. The incidence of RLS was higher in women (75% of the patients were female). Conclusion: We conclude that RLS is a prevalent condition in the elderly and is often under diagnosed.
AKCİĞER ADENOKARSİNOMUNDA TÜMÖR BOYUTU VE HİSTOPATOLOJİK ALT TİPİN SAĞKALIM ÜZERİNE ETKİLERİ

Giris: Akciger kanserinde, bronkoalveoler karsinom ve miks tip adenokarsinom terminolojisi terk edilmistir. Invazif adenokarsinomlar lepidik, asiner, papiller ve solid olarak siniflandirilmaktadir. Bu siniflandirma ile adenokarsinom histopatolojik alt tip tanimlamasina standartizasyon getirilmesi hedeflenmistir. Bu calismanin amaci akciger adenokarsinom alt tiplerinde uzun sureli sagkalimi degerlendirmektir. Gerec ve yontem: Kucuk hucreli disi akciger kanseri nedeni ile opere edilen ve patolojik sonuclari adenokarsinom olan toplam 128 hasta calismaya dahil edildi. Hastalarin demografik ozellikleri, rezeksiyon tipi, tumor boyutu, histolojik alt tipleri ve sag kalimlari degerlendirildi. Bulgular : Calismamizda 109 (% 85.1) erkek ve 19 (% 14.9) kadin olmak uzere toplam 128 hasta vardi. Histopatolojik olarak, asiner paternde 48 olgu (% 37.5), lepidik paternde 32 olgu (% 25), solid paternte 34 olgu (% 26.5) ve 14 olgu (% 10,9) in-situ paternde idi. Histopatolojik tip ve ortalama sagkalim suresi arasinda istatistiksel olarak anlamli bir fark yoktu. Sonuc: Histolojik alt tip hayatta kalma suresi acisindan etkili degildir ancak gelecekte spesifik hedefe yonelik tedaviler ile oldukca onemli hale gelecektir.
The Effect of Camellia Sinensis Ointment on Perineal Wound Healing in Primiparous Women

BACKGROUND AND OBJECTIVE: Delay in recovery of episiotomy can lead to infection and persistence of perineal pain. Perineal pain is a stressful problem for primiparous women and has a negative effect on their function.The present study was conducted to determine the effect of Green tea ointment on the healing process of episiotomy. METHODS: This three-blind clinical trial was conducted on 60 primiparous participated in this research, were divided in two groups: Green tea ointment and placebo ointment. According to the routine of the hospital, 500 mg capsule cephalexin was given to all mothers every six hours for seven days. Mothers used an ointments every 12 hours for a period of ten days in the area of sutures. Wound healing was measured on the fifth and tenth day after delivery using REEDA scale. FINDINGS: There was no significant difference in demographic features and obstetric variables (for example age and weight newborn). Before the intervention, two groups did not have a significant difference in score of the perineal evaluation scale (p=0.475). The average of this scale on the fifth day in the green tea group was (1.83±1.147) and in placebo group it was (3.33±1.155) on the 10th day, the average of the perineal evaluation scale was (1.2±0.805) for the green tea group and (2.63±1.066) for the placebo group. The average of REEDA scores on the 5th and 10th day after delivery was significantly different between the two groups(p<0.00001) CONCLUSION: Green tea can improve episiotomy wound healing, due to its healing properties.
Dual Effect of Ceramide on Human Endothelial Cells

Background— Generation of the second-messenger molecule ceramide by stimulated sphingomyelinase activity has been implicated in the inflammatory processes contributing to the pathogenesis of atherosclerosis. However, reports of stimulatory effects of ceramide on endothelial NO production in animal models suggest antiatherosclerotic effects of the molecule. Therefore, we investigated long-term effects of ceramide on NO generation in human endothelial cells. Methods and Results— In human umbilical vein endothelial cells (HUVECs) and in HUVEC-derived EA.hy 926 endothelial cells, C6-ceramide (N-hexanoyl-d-erythro-sphingosine) reduced the generation of bioactive NO (RFL-6 reporter-cell assay). At the same time, the signaling molecule increased endothelial NO synthase (eNOS) mRNA (RNase protection assay) and protein expression (Western blot). C6-ceramide stimulated eNOS transcription by a signaling mechanism involving protein phosphatase PP2A but did not modify the stability of the eNOS mRNA. Endothelial genera.
Cone-beam computed tomography evaluation of bifid mandibular canal in a Turkish population

Aim: The aim of the study was to examine the prevalence of bifid mandibular canals (BMC) in a Turkish population, using cone-beam computed tomography (CBCT). Methodology: The CBCT images of 350 untreated patients (178 male, 172 female ranging in age between 18 and 65,) were included in this study. The presence or absence of BMC was determined in axial, sagittal, and coronal planes by considering gender and side. For statistical evaluation, a chi‑square test was used to determine any differences in the prevalence of BMC with significance set at 5%. Results: BMCs were observed in 129 out of 700 sides (18.42%) and 97 out of 350 patients (27.71%), of which, 55 were in males and 42 in females. Regardless of gender, the right side was more frequently affected (73%). Male patients showed higher prevalence (15.71%) than the female patients (12%). Conclusion: BMC was observed in 27.71% of examined Turkish subjects and detected more frequently in males and on the right side.
End-systolic volume index at 90 to 180 minutes into reperfusion therapy for acute myocardial infarction is a strong predictor of early and late mortality. The Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO)-I Angiographic Investigators

BACKGROUND: Left ventricular remodeling is an important sequela of myocardial infarction (MI). Although remodeling occurs soon after MI, the effect of early left ventricular dilatation on outcome is not established and may be useful for early risk stratification. We assessed whether end-systolic volume index (ESVI) at 90 to 180 minutes into thrombolytic therapy for MI is associated with adverse outcomes. METHODS AND RESULTS: In the Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO)-I study, 41021 patients with evolving MI received one of four thrombolytic regimens. At 90 or 180 minutes into reperfusion therapy, 1300 patients underwent left ventriculography. ESVI was measured and correlated with adverse outcomes: 30-day and 1-year mortality and in-hospital congestive heart failure, shock, and reinfarction. Clinical variables were also tested in a stepwise logistic regression analysis to determine predictors of left ventricular dilatation. ESVI was directly related to all ad.
Patients' Perceptions of Atrial Fibrillation, Stroke Risk, and Oral Anticoagulation Treatment: An International Survey

Abstract Background Global differences exist in the management of atrial fibrillation (AF), and cultural differences may influence patients' expectations and perceptions of healthcare. This survey investigated whether country-specific differences in patients' perceptions of AF and oral anticoagulation (OAC) exist and if recent stroke influences these perceptions. Methods Cross-sectional survey of 937 adults with nonvalvular AF receiving OAC for stroke prevention was conducted across United States, Canada, Germany, France, and Japan. Thirty-minute online interviews conducted between April and November 2015 included AF patients with recent stroke, and newly diagnosed AF and established AF, both without recent stroke. Results U.S. patients and those with recent stroke perceived AF as more serious (54.0 and 55.2%, respectively) and were more concerned about stroke (50.0 and 68.0%, respectively). Japanese patients were more likely to perceive AF as not serious (41.0%), but 50.4% were frequently concerned about stroke. Patients in the United States, Canada, and Germany and those without recent stroke preferred to be involved in OAC treatment decisions (either shared decision making or patient's choice), while French and Japanese patients and those with recent stroke preferred their doctor to choose. For all country groups, stroke prevention was the most important factor when choosing OAC. Conclusion In this international cohort of AF patients, country-specific differences exist in patients' perceptions of AF, concerns about stroke, and preference for involvement in OAC treatment decisions; recent experience of stroke significantly influenced patients' values and preferences regarding AF and treatment. Stroke prevention was rated as the most important factor when choosing OAC treatment.
Tumor Cell Dormancy: How It Performs in Drug Resistance and Relapse

Despite progresses achieved in the therapy of tumors, the prognosis of patients is still limited by reccurence of residual tumor cells. Cancer cell dormancy plays a pivotal role in cancer relapse and drug resistance. In recent years, tumor cells undergoing EMT (epithelial-mesenchymal transition), CSCs (cancer stem cells) and CTCs (circulating tumor cells) are proved to share some common characteristics and show a cell cycle arrest phenotype. Thus, understanding the dormant stage of tumor cells could facilitate us in discovering ways to accelerate the development of tumor therapy and prevent its reccurence. In this review, we summarize the specific process of tumor cell dormancy induced by pharmacotherapy, and consider that dormancy is an initiative response rather than a passive defense to cytotoxicity. Besides, we probe into the mechanisms of tumor cell dormancy-mediated drug resistance, anticipating paving a way to target dormant tumor cells and result in better clinical outcomes.
Perceived causes of infertility among Women of child bearing age in Ilorin West Local Government Area, Kwara State

This study investigated the Perceived causes of infertility among women of child bearing age in Ilorin West Local Government, Kwara State. Infertility is a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected regular sexual intercourse. This study investigated (i) Smoking and (ii) STI as a cause of Infertility among Women of Child bearing age. A descriptive research design of survey method was employed for this study. The population consists of all women of child bearing age in Ilorin West Local Government. A multistage sampling technique was used to select 241 respondents. Researcher’s structured questionnaire which was validated by three experts from the Department of Health Promotion and Environmental Health Education, Faculty of Education, University of Ilorin was used for data collection. A correlation co-efficient of . 78 ‘r’ was obtained through test re-test method using Pearson Product Moment Correlation. Data collection was conducted by the research and three trained research assistants. The postulated null hypotheses were tested using inferential statistics of chi-square at 0.05 alpha level. The findings from this study showed that: Smoking will significantly be perceived as a cause of infertility among women of child bearing age with the calculated chi-square (χ2) value of 172.66 is greater than the table chi-square (χ2) value of 16.92 at the degree freedom (df) 9 Sexually Transmitted infections will significantly be perceived as a cause of infertility among women of child bearing age with the calculated chi-square (χ2) value of 192.49 is greater than the table chi-square (χ2) value of 16.92 at the degree freedom (df) 9 Based on the findings of the study, it was concluded that smoking and sexually transmitted infections were significantly perceived as causes of infertility among women of child bearing age in Ilorin West Local Government, Kwara State. Therefore, it was recommended that Health workshops should be organized to enlighten women in Ilorin West Local Government about the dangers involve in smoking and its effect on fertility and the knowledge of causes and prevention of STIs should be spread among women in order to curb the problem of infertility.
Research the relationship between obesity and depression ın outpatient clinics

2018 © Yayın hakları Türkiye Aile Hekimleri Uzmanlık Derneği’ne (TAHUD) aittir. Medikal Akademi tarafından yayımlanmaktadır. Bu makalenin koşullu kullanım hakları Medikal Akademi ve TAHUD tarafından Creative Commons Attribution-NoCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND3.0) lisansı aracılığıyla bedelsiz sunulmaktadır. Copyright © 2018 Turkish Association of Family Physicians (TAHUD). Published by Medikal Akademi, Istanbul. This article is licensed by Medikal Akademi and TAHUD under the terms of Creative Commons Attribution-NoCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND3.0) License. Poliklinik başvurularında obezite ve depresyon ilişkisinin incelenmesi
Pathophysiology, treatment and experimental models of rheumatoid arthritis

The rheumatoid arthritis, is the inflammatory polyarthritis commonest in adults affecting about the 1 % of world population, more predominant in women than men and more frequent in those aged 30 and 50 and entails a high level of inability of patient. It is characterized by a symmetrical erosive synovitis with proliferation of conjunctival tissue (pannus), invading and eroding the cartilage and joint bones, and sometimes, by a multisystem affection. In most patients the disease follows a fluctuating chronic course, which it is not treated, provoke a progressive destruction, deformity and inability of involved joints. The disease evolves with high figures of rheumatoid factor and/or anticitrulline antibodies. These are essential features of an optimal treatment of this entity include: early differential diagnosis, initial treatment with non-steroidal anti-inflammatory drugs (NSAIDs), the use of disease course modifying drugs, the potential use of oral low-dose glucocorticoid agents or intraarticular injections, and a periodical assessment of treatment fitting (radiological serum and functional monitoring of disease progression and of treatment-associated toxicity) and the educational and rehabilitations interventions of patient. To assess the new therapies for treatment of rheumatoid arthritis, the more uses models are: that of the arthritis induced by adjuvant drugs in rats and the arthritis induced by collagen in rats and mice. Other new models show limited data. Effectiveness of several compounds reveals that its therapeutic effect is more predictive of the clinical effect in the human being when models of arthritis due to adjuvant drugs and collagen than data from an only one model.
Appeals

On Friday this week Mr. C. Gulliver is giving a matinee at the London Palladium in aid of the Seamen's Hospital. Greenwich. The programme will be contributed to by about a dozen of the best known vaudeville performers of the day. The King has sent a cheque to Mr. E. Gray, hon. organiser of the matinee, with instructions to invite a number of sailors to the performance. Others are invited to follow His Majesty's example. All are interested
A case report: Acute neuromyelitis in pregnancy

Neuromyelitis optica spectrum disorder (NMOSD) is a demyleinating disease of the central nervous system. NMOSD is characterized by severe relapse of optic neuritis, longitudinal extensive myelitis and the presence of anti aquaporin-4 IgG (AQP4-IgG) in serum. Female factors like genetic, epi-genetic, or hormonal, may play an important role in pathogenesis. Female gonadal hormones, estrogen and progesterone, rise significantly during pregnancy, and decrease during the postpartum period. We are reporting a case of Gravida 2 Para1 Living1 Abortion 0 with full term with known case of acute neuromyelitis (on treatment for 3 years). Patient delivered vaginally, post natal period was uneventful.
Perspectives On Care And Caring: An Innovative Model Of Holistic Nursing

102 Homeless individuals have complex lives. To offset the chaos of their personal lives and histories, clinical interactions that foster helping-trusting relationships are important because they enhance opportunities for creative problem solving and sustainable health outcomes in this population. Stout Street Clinic provides unique, holistic caring for homeless persons through a model that conjoins medical, mental health, and housing services within a single clinic setting. This creative model affords homeless patients seamless access to services designed to meet multiple and related human needs. Within the context of this model, patient needs provide a focus for provider collaboration and action, and clinicians engage with each other and patients in ways that embody both the dimensions and spirit of the theory of human caring. The purpose of this paper is to illustrate successful practices and relationships through which we reduce barriers to caring and enhance both patient and clinician experiences in the clinic. One family nurse practitioner and one psychiatric-mental health clinical nurse specialist initiated a model in which each periodically shadows the other in clinical interactions with patients. In these interactions, there is a synergy of clinical knowledge and caring as mental and physical health are integrated. Perspectives On Care And Caring: An Innovative Model Of Holistic Nursing
Infection prevention and control in paediatric office settings

Abstract Transmission of infection in the paediatric office is an issue of increasing concern. This document discusses routes of transmission of infection and the principles of current infection control measures. Prevention includes appropriate office design and administrative policies, triage, routine practices for the care of all patients (e.g., hand hygiene; use of gloves, masks, eye protection, and gowns for specific procedures; adequate cleaning, disinfection, and sterilization of surfaces and equipment, including toys; and aseptic technique for invasive procedures), and additional precautions for specific infections. Personnel should be adequately immunized, and those infected should follow work-restriction policies.