Miracle-dz/UniFAR-FTUs huggingface dataset:
Young Children and Adults’ Sensitivity to Contexts for Social Conventions in Make-Believe Play

Abstract The author focused on how young children understand the nature of social conventions relating to pretend play. Twenty 4-year-olds, fifteen 6-year-olds, and 20 adults (undergraduate students) listened to vignettes in which a new child in each vignette violated a convention used by other children while playing. Participants indicated whether the violations would be corrected and whether someone needed to teach the conventions to the new children. The scope of a convention (wide versus narrow) in combination with how long the convention has been used affected 6-year-olds’ responses but not the responses of younger children or adults. In addition, there were age-related differences in participants’ beliefs about who could teach characters about the conventions and why characters might not need to be taught by others. These results demonstrate that children at the start of middle childhood can be sensitive to contextual differences in the conventions that shape everyday activities more so than adults and younger children.
Contextual Assesments and Biomarker in Agitation Prediction for ADHD Patients

ADHD has an estimated worldwide prevalence of 2-3% and is one of the most frequent neurodevelopmental disorders. The disease starts in childhood and persists in up to 50% into adulthood. Many problems in an ADHD-patient's life arise from the lack of self-management abilities. Technologies may be able to support adolescents and adults with ADHD by strengthening self-awareness of their symptoms, monitoring treatment and helping to develop responsibility, emotional self-regulation and self-management. In our work, we develop a modular on-body system which supports self-management of psychological disorders for young adults unobtrusively in everyday life. We present insights into the future concept of an assessment system based on contextual experience sampling and biomarkers, to predict agitated situations and enable patients to reflect on their own behaviors.
Transfer RNA Modification Enzymes from Thermophiles and Their Modified Nucleosides in tRNA

To date, numerous modified nucleosides in tRNA as well as tRNA modification enzymes have been identified not only in thermophiles but also in mesophiles. Because most modified nucleosides in tRNA from thermophiles are common to those in tRNA from mesophiles, they are considered to work essentially in steps of protein synthesis at high temperatures. At high temperatures, the structure of unmodified tRNA will be disrupted. Therefore, thermophiles must possess strategies to stabilize tRNA structures. To this end, several thermophile-specific modified nucleosides in tRNA have been identified. Other factors such as RNA-binding proteins and polyamines contribute to the stability of tRNA at high temperatures. Thermus thermophilus, which is an extreme-thermophilic eubacterium, can adapt its protein synthesis system in response to temperature changes via the network of modified nucleosides in tRNA and tRNA modification enzymes. Notably, tRNA modification enzymes from thermophiles are very stable. Therefore, they have been utilized for biochemical and structural studies. In the future, thermostable tRNA modification enzymes may be useful as biotechnology tools and may be utilized for medical science.
Nonpharmacological management of sleep disturbances after traumatic brain injury.

BACKGROUND Sleep plays an integral role in several physiologic functions such as cognition and functional ability. Sleep disturbances are common after brain injury and can interfere with rehabilitation and recovery. There are several pathways by which sleep is initiated, and thus various ways to target common complaints as well. OBJECTIVES To review alternative and non-pharmacological treatment approaches to sleep disorders following TBI. METHODS The authors present a review of the literature on various alternative treatment methods for treating sleep disorders, and discuss evidence for safety and efficacy. CONCLUSIONS Typical management include conservative measures and pharmacologic treatment. This article provides a review of the available nonpharmacologic treatment options for sleep disorders in patients with traumatic brain injury. There are a number of non-pharmacological treatment methods available for treatment of sleep disorders in this population.
Calcipotriol/betamethasone dipropionate aerosol foam for the treatment of psoriasis vulgaris: case series and review of the literature

An aerosol foam formulation of a once-daily, fixed-dose combination of a synthetic vitamin D3 analog/synthetic corticosteroid (calcipotriol [Cal] 50 µg/g and betamethasone dipropionate [BD] 0.5 mg/g) has recently been introduced for the topical treatment of plaque psoriasis in adults. Data from several sources – randomized controlled trials, case reports (as highlighted in this review), and real-world evidence (RWE) – underscore the considerable and rapid clinical response, effectiveness, and favorable safety and tolerability of Cal/BD aerosol foam in mild-to-moderate psoriatic patients previously treated with class 3 or 4 topical corticosteroids, in patients unsatisfied with ongoing phototherapy in combination with topical therapy and in patients with moderate-to-severe psoriasis. In addition, our case series, considered together with other RWE, highlights that Cal/BD aerosol foam is more effective and with greater levels of patient preference and acceptability than comparator preparations. Thus, Cal/BD aerosol foam offers several treatment advantages, including relief of itch, and is an appropriate first-line topical therapy for consideration in patients with psoriasis of any severity.
Acute Effects of Music Therapy in Subjects With Psychosis During Inpatient Treatment

Objective: Previous studies have proposed music therapy (MT) as a useful rehabilitation approach for patients with psychosis, but few studies have focused on acute settings. The aim of the study was to evaluate the effects of a structured MT program on clinical and social functioning indices of patients with psychosis while hospitalized in an emergency psychiatric ward. Method: The intervention followed a modified approach to Benenzon’s MT model and was delivered biweekly to 61 patients with psychosis consecutively admitted to our ward. Before and after the MT program, all subjects were administered the Brief Psychiatric Rating Scale (BPRS) for assessment of general psychopathology, the Hospital Anxiety and Depression Scale (HADS) for affective symptomatology, the Clinical Global Impression (CGI) scale for severity of symptoms, and the Global Assessment of Functioning (GAF) scale for psychosocial functioning. Results: A repeated-measures analysis of variance revealed that patients who underwent the MT intervention had a statistically significant reduction of BPRS and CGI scores, compared to the control group; furthermore, the BPRS anxiety/depression factor and the HADS scores for affective symptomatology significantly decreased after the observation period compared to controls. Conclusion: Our results are in line with previous studies showing favorable effects of MT in patients with psychosis, in particular on affective symptomatology, but extend this observation to an emergency setting with short periods of hospital stay.
Overexpression of Arabidopsis ubiquitin ligase AtPUB46 enhances tolerance to drought and oxidative stress

The U-Box E3 ubiquitin ligase, AtPUB46, functions in the drought response: T-DNA insertion mutants of this single paralogous gene are hypersensitive to water- and oxidative stress (Adler et al. BMC Plant Biology 17:8, 2017). Here we analyze the phenotype of AtPUB46 overexpressing (OE) plants. AtPUB46-OE show increased tolerance to water stress and have smaller leaf blades and reduced stomatal pore area and stomatal index compared with wild type (WT). Despite this, the rate of water loss from detached rosettes is similar in AtPUB46-OE and WT plants. Germination of AtPUB46-OE seeds was less sensitive to salt than WT whereas seedling greening was more sensitive. We observed a complex response to oxidative stress applied by different agents: AtPUB46-OE plants were hypersensitive to H2O2 but hyposensitive to methyl viologen. AtPUB46-GFP fusion protein is cytoplasmic, however, in response to H2O2 a considerable proportion translocates to the nucleus. We conclude that the differential stress phenotype of the AtPUB46-OE does not result from its smaller leaf size but from a change in the activity of a stress pathway(s) regulated by a degradation substrate of the AtPUB46 E3 and also from a reduction in stomatal pore size and index. Accession Numbers Sequence data for this article can be found in: The Arabidopsis Information Resource database (http://www.arabidopsis.org) under accession numbers At5G18320 (PUB46).
miRNA-Mediated Interactions in and between Plants and Insects

Our understanding of microRNA (miRNA) regulation of gene expression and protein translation, as a critical area of cellular regulation, has blossomed in the last two decades. Recently, it has become apparent that in plant-insect interactions, both plants and insects use miRNAs to regulate their biological processes, as well as co-opting each others’ miRNA systems. In this review article, we discuss the current paradigms of miRNA-mediated cellular regulation and provide examples of plant-insect interactions that utilize this regulation. Lastly, we discuss the potential biotechnological applications of utilizing miRNAs in agriculture.
Validation and Investigation of the Operating Characteristics of the Ulcerative Colitis Endoscopic Index of Severity.

BACKGROUND The Ulcerative Colitis Endoscopic Index of Severity (UCEIS) is a novel instrument to evaluate endoscopic disease activity. It has been demonstrated to outperform the more widely used Mayo endoscopic score (MES) in predicting long-term prognosis, including the need for colectomy. Despite its potential benefits, many clinicians still prefer to use MES because its operating characteristics are better defined and its grades are more readily applicable to clinical decision-making. The aims of our study were to quantify the UCEIS cutoff most closely associated with the need for treatment escalation and to perform a validation exercise using MES and clinical, biochemical, and histological measures of disease activity. METHODS Endoscopies performed in UC patients between November 2016 and January 2018 were retrospectively reviewed. Agreement between the UCEIS and MES was quantified using Kappa (κ) statistics. A UCEIS cutoff for treatment escalation was calculated using chi-square, receiver operating characteristic curve, and area under the curve (AUC) analyses. The Pearson correlation coefficient was used to compare linear relationships between UCEIS and clinical (Simple Clinical Colitis Activity Index [SCCAI]), biochemical (C-reactive protein [CRP]), and histological (Nancy Histological Index [NHI]) activity. RESULTS Two hundred one (56%) procedures documented both UCEIS and MES, demonstrating substantial agreement (κ = 0.713; P < 0.001). Treatment was escalated after 199 (56%) procedures. Receiver operating characteristic curve analysis of need for treatment escalation showed the highest sensitivity and specificity for UCEIS ≥4 (0.80 and 0.93, respectively; AUC, 0.93). Of 170 patients with a UCEIS ≥4, treatment was escalated in 159 (94%), but not for 11 (6%). Of 185 patients with a UCEIS ≤3, 40 (22%) were escalated, whereas 145 (78%) were not (P < 0.001). UCEIS correlated strongly with NHI (0.723; P < 0.001), moderately with SCCAI (0.671; P < 0.001), and weakly with CRP (0.279; P < 0.001). CONCLUSIONS A UCEIS ≥4 was significantly associated with treatment escalation. This cutoff could therefore be used to support clinical decision-making based on endoscopic findings. Strong and moderate correlations were found between UCEIS and histological and clinical disease activity, respectively, whereas a weak correlation was found with CRP. 10.1093/ibd/izy325_Video_1 izy325.video1 5849933952001.
Challenges of Multileaved Comparison in Practice: Lessons from NTCIR-13 OpenLiveQ Task

This paper discusses challenges of an online evaluation technique, multileaved comparison, based on the analysis of evaluation results in a community question-answering (cQA) search service. NTCIR-13 OpenLiveQ task offered a shared task in which participants addressed an ad-hoc retrieval task in a cQA service, and evaluated their rankers by multileaved comparison, which combines multiple rankings to generate a single search result page, and simultaneously evaluates the different rankings based on users' clicks on the search result page. Since the number of search result impressions during the evaluation period might not suffice to evaluate a hundred of rankers, we conducted the online evaluation only for rankers that achieved high performance in offline evaluation. The analysis of evaluation results showed that offline and online evaluation results did not fully agree, and a large number of users' clicks were necessary to find a statistically significant difference for every ranker pair. To cope with these problems in large-scale multileaved comparison, we propose a new experimental design that evaluates all the rankers online but intensively tests only the top-k rankers. Simulation-based experiments demonstrated that Copeland counting algorithm could achieve high top-k recall in the top-k identification problem for multileaved comparison.
Predicting Personal Life Events from Streaming Social Content

Researchers have shown that it is possible to identify reported instances of personal life events from users' social content, e.g., tweets. This is known as personal life event detection. In this paper, we take a step forward and explore the possibility of predicting users' next personal life event based solely on the their historically reported personal life events, a task which we refer to as personal life event prediction. We present a framework for modeling streaming social content for the purpose of personal life event prediction and describe how various instantiations of the framework can be developed to build a life event prediction model. In our extensive experiments, we find that (i) historical personal life events of a user have strong predictive power for determining the user's future life event; (ii) the consideration of sequence in historically reported personal life events shows inferior performance compared to models that do not consider sequence, and (iii) the number of historical life events and the length of the past time intervals that are taken into account for making life event predictions can impact prediction performance whereby more recent life events show more relevance for the prediction of future life events.
CONTROLE DE IRRIGAÇÃO E AVALIAÇÃO DE PRODUTIVIDADE DE TRÊS CULTIVARES DE RÚCULAS IRRIGADAS POR FITAS POROSAS

The aim of the experiment was to evaluate the biomass of three cultivars of irrigated arugula using the RDI system. The experiment was conducted in a protected environment in scheme of subsplit plot , with the plots three certain irrigation water according to the operation of the RDI in (6, 12 and 24 hours / day ) , the subplots rocket cultivars (Folha Larga Feltrin , Cultivada Feltrin and Antonnela ISLA ) , with three replications. Biomass fresh and dry was assessed as fresh weight of shoot. There that, to cultivate Folha Larga was expressed that increased biomass when subjected to the operation of the system for 12 hours providing water in the plant, was higher than other 1 Eng. Agrônomo. Mestrado, Departamento de Engenharia Agrícola/UFV, CEP 36570-000, Viçosa, MG. Fone (83) 9 9803-6402. Email: cassioalvino@hotmail.com 2 Doutora, Professora DEA/UFV, Viçosa Minas Gerais. E-mail: catariny@ufv.br 3 Professor Titular DEA/UFV, Viçosa – Minas Gerais. E-mail:everardo@ufv.br 4 Acadêmico de Agronomia, Viçosa Minas Gerais. E-mail: rodrigodalsasso@hotmail.com 5 Acadêmico de Agronomia, Viçosa Minas Gerais. E-mail: rgomesmartins1@gmail.com F. C. G. Alvino et al. biomass, operation of the system for 12 hours providing water in the plant, was higher than other biomass.
Ubiquitin‐independent, Proteasome‐mediated targeted degradation of KRAS in pancreatic adenocarcinoma cells using an engineered ornithine decarboxylase/antizyme system

The oncogene KRAS not only promotes the tumorigenesis of pancreatic cancers but also is required for the malignant progression and metastasis of these cancers. Many methods have been explored to influence the malignant biological behavior of these cancers by targeting mutant KRAS. The ornithine decarboxylase/antizyme (ODC/AZ) system is another protein degradation pathway that exists in nature. The formation of an ODC and protein substrate complex through direct combination can promote its degradation by the 26S proteasome without ubiquitination, and this process can be catalyzed by AZ. In this study, we designed and reconstructed a chimeric fusion protein (named RC‐ODC). The engineered fusion protein RC‐ODC was confirmed to interact with the mutant KRAS oncoprotein in a co‐immunoprecipitation assay, and the introduction of both RC‐ODC and AZ resulted in degradation of the exogenous and endogenous mutant KRAS oncoprotein at the post‐translational level independent of ubiquitination in vitro. Along with a decreased KRAS level, suppression of PANC‐1 cell proliferation was detected in vitro and in vivo, and meanwhile downregulation of phosphorylated extracellular signal‐regulated kinase 1/2 (ERK1/2) was also observed. Targeted degradation of the KRAS oncoprotein through the ODC/AZ pathway at the post‐translational level may reflect a more effective future therapeutic strategy for pancreatic cancer patients. © 2018 The Authors. IUBMB Life published by Wiley Periodicals,Inc. on behalf of International Union of Biochemistry and Molecular Biology, 71(1):57–65, 2019
Exploring Video Game Design and Player Retention- a Longitudinal Case Study

Lasting player engagement is essential for pushing a video game beyond a successful release. While previous research on retention and engagement in games exists, this has mainly focused on general models and factors. Furthermore, we notice a lack of published studies using longitudinal methods to investigate when and why player interest drops off. In this paper we present a longitudinal case study of players' attitude on specific game elements which enabled us to in more detail determine why and how the appeal of a game changes. For the case study we selected a AAA game just before release and approached eager participants who wanted to play the game. The seven participants were selected based on interviews and then played freely for 20 hours over five weeks during which they were instructed to fill in player diaries at specified times. At the end of this period, the participants were again interviewed about their experience. The results show that all participants felt less excited about the game, less inclined to play more, and more bored at the end of the period than at the start. No single satisfactory explanation for this development could be deduced from the data. Instead, this article suggests a list of retention breakdown mechanics that were central in this case to maintain player retention. The method to find retention inhibiting factors can be applied as part of the later stages of the development of games to prevent early drop-off.
A Privacy Risk Assessment Model Based on TAPE Framework

With1 the development of online social media platform, people are gaining more opportunities to show themselves, meanwhile, more personal information will be exposed to the public. This paper proposes a user's privacy risk assessment model based on the Trust-Aware framework, which introduces two parameters --- privacy awareness and trust- awareness. And the model also integrates the needs of users in the actual application situation, quantitatively assessing the risk of privacy leakage that may be caused by users' online social behavior in three aspects: user's privacy awareness, social risk and content risk. The assessment model also generates a visual assessment report in forms of charts to help users fully and objectively recognize the potential privacy leakage in the OSNs, and establish the right sense of privacy. Tests result shows that the assessment model can accurately and comprehensively summarizes the full online social behavior of users, and assesses the probability of privacy leakage. Practical operation shows that the system has good stability. The assessment model provides a new idea for online social platform service providers to protect their users' data, which has practical and promotional value.
Comparative Analysis of Color Edge Detection for Image Segmentation

Nowadays understanding of image processing and pattern recognition is the great focus to develop an application of image segmentation. Edge detection is the fundamental technique that can provide information of the boundaries in different objects in an image. Selecting a suitable edge detection algorithm is important to obtain the best performance of segmentation. This paper presents an analysis of implementation for various edge detection techniques on color spaces. We implement Sobel, Prewitt, Robert, and Laplacian edge detection on Hue, Saturation, Value (HSV) and YUV color space by using threshold = 65. We calculated the mean square error (MSE), root mean square error (RMSE), peak signal to noise ratio (PSNR) and execution time as a comparison. This paper tested images from Berkeley Segmentation Dataset (BSDS). The results showed that Robert edge detection in HSV color space especially hue channel can be utilized to obtain more precise boundaries in different objects and it is also quick to compute.
Clinical Implications of Real-time and Intermittently Scanned Continuous Glucose Monitoring

Two types of continuous glucose monitoring (CGM) systems are now available: real-time CGM (rtCGM) and intermittently scanned (isCGM). Current rtCGM systems automatically transmit a continuous stream of glucose data to the user, provide alerts and active alarms, and transmit glucose data (trend and numerical) in real time to a receiver, smart watch, or smartphone. The current isCGM system provides the same type of glucose data but requires the user to purposely scan the sensor to obtain information, and it does not have alerts and alarms. Both CGM technologies have significant advantages over self-monitoring of blood glucose; however, differences in the features and capabilities of the two approaches must be considered when guiding patient selection of the system that meets their individual needs.