Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel Findings in Familial Nonmedullary Thyroid Cancer Genetics

Thyroid cancer (TC) is the most common endocrine malignancy and its incidence has been increasing sharply since the mid-1990s [1]. TC is a general term that comprises two main groups of neoplasias, depending on the cell type affected by the malignant transformation. 1) Carcinomas originating from the follicular epithelium, referred to as nonmedullary thyroid cancer (NMTC) representing more than 95% of all TC; and 2) carcinomas originating from the parafollicular thyroid C cells, referred to as medullary thyroid cancer (MTC) accounting less than 5% of all TC.
Miniaturized implantable power transmission system for biomedical wireless applications

In this paper, a complete wireless power transmission scenario is presented, including an external transmission antenna, an in-body embedded antenna, a rectifying circuit, and a powered sensor. This system operates at the Industrial, Scientific, and Medical bands (902.8–928 MHz). For the antenna design, important parameters including reflection coefficient, radiation pattern, and specific absorption rate are presented. As for the rectifying circuit, a precise model is created utilizing off-the-shelf components. Several circuit models and components are examined in order to obtain optimum results. Finally, this work is evaluated against various sensors' power needs found in literature.
Retrieval of Aerosol Optical Thickness in the Arctic Snow-Covered Regions Using Passive Remote Sensing: Impact of Aerosol Typing and Surface Reflection Model

Currently, no aerosol optical thickness (AOT) data set over the Arctic snow/ice-covered regions derived from space-borne passive remote sensing is available. The challenge is to develop an accurate and robust technique to derive AOT above highly variable and bright snow/ice surfaces. To extend data coverage of the eXtensible Bremen Aerosol/cloud and surfacE Retrieval (XBAER) AOT data product in the future, we propose a new algorithm for the retrieval of AOT and surface properties over snow/ice simultaneously. The algorithm utilizes the linear perturbation theory and does not use any simplified atmospheric correction techniques. Key issues like the selection of a proper aerosol type and optimal surface parameterization method for the retrieval of AOT over the Arctic have been investigated. The aerosol type is investigated using the aerosol climatology microphysical properties derived from four Aerosol Robotic Network (AERONET) sites (Barrow, Hornsund, Kangerlussuaq, and Tiksi). The three-parametric Ross-Li linear kernel model is used to describe the snow bidirectional reflectance distribution function (BRDF). The a priori knowledge of wavelength-dependent features of the coefficients in the Ross-Li linear kernel model is derived from Polarization and Directionality of the Earth’s Reflectances (POLDER) measurements over the Arctic and utilized as constraints in the retrieval. The studies show that the combination of Ross-Li surface model and weakly absorbing aerosol parameterization provides an optimal way to derive AOT over the Arctic snow/ice-covered regions from passive remote sensing observations. The retrieved AOTs using POLDER show good agreement with AERONET observations.
Effect of Obesity on Serum Vitamin D Metabolites Using Obese Zucker RatModel

The obesity epidemic in the US has continued for over two decades as the proportion of overweight and obese adults in the population continues to rise. Also, obesity has been linked with the risk of development of various diseases such as diabetes, cardiovascular disease and certain types of cancers. There are conflicting reports about the effects of obesity on serum vitamin D levels in human and animal models. We hypothesize that obesity will affect the serum levels of vitamin D metabolites. Therefore, the objective of this study was to investigate the influence of obesity on the serum concentrations of two metabolites of vitamin D [25-(OH)-D and 1,25-(OH)2-D] in rats. Sixteen 5-week-old female Zucker rats (8 obese fa/fa and 8 lean) were acclimated for one week, and at the age of 42 days, the rats were housed 2 per cage with ad libitum access to water and AIN-93G diet. Rats were weighed twice weekly. At the end of the experiment (8 weeks), all rats were sacrificed and serum was collected and stored at −20°C. Serum concentrations of 25-OH-D and 1,25-(OH)2-D were measured using HPLC-UV. Data were analyzed using Excel software and presented as mean ± SD. Obese rats had significant weight gain (P<0.001). Serum concentration of 25-(OH)-D metabolite in obese rats was significantly (P<0.05) lower compared to lean rats. At the same time, serum concentration of 1,25-(OH)2-D metabolite in obese rats was only 8% lower and did not significantly (P<0.3) change compared to the lean group. The serum ratio of 1,25-(OH)2-D:25-(OH)-D was approximately 10% higher (P<0.3) in obese rats compared to the lean group. In summary, lower serum concentration of 25-OH-D (hormonally inactive form of vitamin D) metabolite is consistent with higher body mass in rats, but obesity did not affect the serum concentration of 1,25-(OH)2-D. Our results show that the obese Zucker rat can be a good model for assessing vitamin D status.
The effect of aerobic continuous training and detraining on left ventricular structure and function in male students

Цель: Регулярные занятия физическими упражнениями вызывают сердечную физиологическую гипертрофию. Цель данного исследования состояла в том, чтобы определить влияние аэробной непрерывной тренировки и периода отдыха на структуру левого желудочка и функции сердца у не спортсменов здоровых мужчин. Материал : Десять неподготовленные здоровых студентов мужского пола (в возрасте 18-22 лет) добровольно участвовали программе непрерывного бега трусцой (3 дня/неделю, на 70% от максимальной частоты сердечных сокращений в течение 45 мин, 8 недель) в сельской местности и четыре недели после период отдыха. Использовали: M-режим, 2-мерная, цвет и доплеровская трансторакальная эхокардиография в условиях покоя, а также до и после тренировки и после периода отдыха. Результаты : Использование t-теста позволило обнаружить существенную разницу в диаметре конечного систолического давления и толщины задней стенки, процентное укорочения и фракцию выброса после восемь недель тренировки. Не было обнаружено существенных различий в конечном диастолическом диаметре, толщине межжелудочковой перегородки, диаметре левого предсердия, диаметра аорты, частота сердечных сокращений, систолического и диастолического артериального давления. После четырех недель периода отдыха после тренировки по сравнению с 8 неделями занятий обнаружена значительная разница конечного диастолического диаметра, процента укорочения и фракции выброса. Не обнаружено существенной разницы в диаметре конечного систолического, толщине задней стенки, межжелудочковой толщине перегородки, диаметре левого предсердия, диаметре аорты, частоте сердечных сокращений, систолическом и диастолическом давление крови. Выводы . В общем, восемь недель аэробной непрерывной тренировки и периода отдыха могут оказывать неблагоприятное воздействие на структуру левого желудочка и функции сердца.
Impact of the Passive Component Structure for High Efficiency and Fast Response POL Using Power Supply on Chip

Power-SoC, which integrates MCU, power device, control circuits and passive devices on the same chip has been attracted attention. In this paper, we discuss the design consideration of high efficiency and fast response POL using 3D Power-SoC (Supply on Chip). We propose the optimal structure according to the switching frequency based on simulations.
Foreign Trade in Special Economic Zones in Poland

The book covers unique approach to the analysis of foreign trade. It presents a macroeconomic, mesoeconomic and microeconomic perspective on the effects of special economic zones operation with regard to foreign trade to provide a better understanding of consequences of SEZs’ establishment (for country, region or a firm). To the knowledge of the authors, this is the first (so comprehensive) evaluation of SEZs functioning thereof. The monograph summarizes a significant part of the results of the research project entitled “Foreign Trade in Special Economic Zones in Poland”, financed by the National Science Centre in Poland (project no. DEC-2013/11/D/HS4/04007). The project aimed at identifying the real impact of SEZs on Poland’s trade turnover. Its implementation focused on expanding the available scope of knowledge on the impact of the SEZs on the Poland’s trade and has enabled to join in the ongoing national and international academic debate on further functioning of various types of areas of special preference. Moreover, the research permitted for identification of microeconomic determinants of the impact of the SEZs on business entities in terms of their export activities contributing to a widening of scientific achievements in the field of economics.
Spanish validation and cultural adaptation of the Five-Word Test for the detection of the neurocognitive disorder in older adults

Introduction. “Episodic” memory problems are common in people with cognitive impairment due to Alzheimer’s disease and related disorders. Dubois et al. developed the Five-Word Test (5WT) to evaluate episodic memory, which has proved to be an easy and valid test for identifying cognitive disorders. However, its validation and cultural adaptation from French to Spanish has not been undertaken and its usefulness in Mexican population is unknown. Objective. Validation and cultural adaptation of the 5WT for screening minor and major neurocognitive disorder (ND) in Mexican older adults with probable Alzheimer’s disease. Method. Two hundred and fifteen participants (70 cognitively healthy subjects, 73 with minor ND and 72 with major ND were included). The cognitive status (gold standard) was determined using current clinical criteria and neuropsychological evaluation. The Spearman coefficient, ROC curve, and multinomial logistic regression models were used to determine the concurrent validity of the 5WT. Results. The correlation between the 5WT and the Mini-Mental State Exam (MMSE) was . 58, whereas for the clock face test it was -. 37 ( p < .001). The area under the 5WT curve was . 97 (95% CI [.94, .99]), with a cut-off point of ≤ 16/20 for the diagnosis of major ND (89% sensitivity, 98% specificity) and . 77 (95% CI [.70, .85]) for minor ND with a cut-off point of ≤ 18/20 (66% sensitivity, 77% specificity). Discussion and conclusion. Since the 5WT is a simple, valid instrument for the identification of neurocognitive disorders like Alzheimer’s disease, it could be a practical screening test.
The function of Extract Curcuma (Curcuma xanthorrhiza Roxb) In Restoring Hemoglobin, erythrocyte and hematocrit 1 On Soccer Athlete

The purpose of this study is to determine the effect of giving temulawak (Curcuma Xanthorrhiza Roxb) in athletes after having running activity 5000 meters toward hemoglobin, erythrocyte and hematocri level. The research design is double blind randomized controlled trial. The subjects were 35 male football athletes from PPLP (Centre for Education and Training Student) Salatiga, Central Java. The subjects were divided into 5 group with different treatments; group I giving temulawak extract capsule containing curcumin (ETKK) 250 mg / day, group II ETKK 500 mg / day, group III ETKK750 mg / day, group IV were given multivitamin and mineral (MVM) capsules per day (beta carotene 5000 UI, Vitamin E 200 UI, Vitamin C 500 mg, 15 mg zinc, selenium 50 mcg) and group V were given placebo while the capsule were given for 21 days. The giving of temulawak extract (Curcuma xanthorrhiza Roxb) gave no effect on the improvement of hemoglobin levels, eritrsit and hematocrit in athletes after having 5000 meters running test.
…so little time, and …

One recurring criticism of evidence based medicine is that no one has sufficient time to practice it (the irony should not be lost when this criticism is juxtaposed with the counter-claim that “everyone is already doing it”). How much time do we have for practising evidence-based medicine? Readers of this EBM note will not be surprised to discover that data on this important issue are thin, highly variable, and more than a bit suspect, even for so circumscribed a step in the evidence-based medicine process as tracking down and examining the evidence.
INJECTION BOTULINUM IN PARALYTIC STRABISMUS

AIM: To assess the effectiveness of botulinum toxin injection to the antagonist muscle in paralytic strabismus. OBJECTIVE: To study the effect of botulinum toxin a injection into the antagonist muscle in cases of paralytic strabismus to alleviate diplopia. MATERIAL AND METHODS: This was a tertiary eye care hospital based prospective interventional study in the department of Orthoptics over a period from October 2011 to October 2013. 36 patients with paralytic strabismus of recent onset within 3 months, with chief complaint of double vision were included. RESULTS: The study data analysis of 36 patients of paralytic strabismus of recent onset (within 3 months) with chief complaints of double vision showed age wise distribution as 3(8.33%) in 0-20 years, 16(44.44%) in 21-40 years, 16(44.44%) in 41-60 years, 1(2.78%) > 60 years. gender wise 26(72.22%) males, 10 (27.28%) females, aetiology wise 15(41.67%) were diabetic, 4(11.11%) were traumatic, 11(30.56%) were Idiopathic, 2(5.56%) were due to CSOM and 4(11.11%) due to Diabetes and Hypertension. All patients were treated with botulinum toxin injection to the antagonist nonoperatic muscle and were followed at an interval of 1 week, 1 month and 3 months. Thorough clinical examination and Diplopia charting were done before and after treatment. CONCLUSION: Injection botulinum into the antagonist muscle during the first three months after the onset allows the patients to enjoy and appreciate fusion in primary gaze without necessity for head turn, Prevents contracture of antagonist muscle. Thus botulinum toxin is useful in the treatment of acute paretic loss of ocular muscle function when surgical treatment of the ocular muscles is not yet possible but the patient is obviously disturbed by diplopia or forced head posture. The procedure is simple, safe and effective method.
E-Commerce in Saudi Arabia: Characteristics of a Trustworthy Usable E-commerce Websites

The aim of this paper is to improve the performance of e-commerce in Saudi Arabia through assisting Saudi retailers to reinforce their presence through a usable and trustworthy e-commerce website especially after the Saudi E-commerce Law been into effect. The advantage is that the Saudi stores will be more convenient to customers, gain their trust and contribute to the Saudi vision 2030. A questionnaire survey has been conducted to know the e-commerce websites mostly used by Saudis and why they have been chosen. 280 university students representing different regions and cultures of Saudi Arabia have been chosen to participate. Studies of website usability and usability inspection methods have been visited by this paper to identify the technical factors that contribute to improving website usability and to assist the Saudi e-commerce organizations overcome usability issues. This paper also talks about the vulnerability of cloud technology and social media when used for storing business and personal data for e-commerce purposes. Plus, it encapsulates the legal requirements such as data privacy as trust enhancing factors. Hence, this study is beneficial for Saudi law makers as it illustrates the requirements that should be part of the Saudi Data Privacy law which is not yet finalized. Although this study focuses on Saudi e-commerce, it is beneficial to the Saudi e-government as website usability and usability inspection methods are applicable to all websites. As a result, the online performance of the Saudi stores is week and need to be strengthened. Strong e-commerce activity make Saudi stores not only reach more customers and gain their trust but also contribute to achieving the Saudi government goals illustrated in the Saudi vision 2030.
P-130 Implementation of electronic patient records – a hospice journey

Background Electronic patient records were successfully implemented at all sites of St Ann’s Hospice in September 2016. A scoping exercise selected EMIS Web, and an implementation group was formed in December 2015. Method The implementation group consisted of 16 individuals including a project lead, multi-disciplinary healthcare professionals and administrative staff. The project lead was accountable to a board; compromising service managers and executive directors. Implementation group meetings occurred fortnightly in the planning stages, then weekly at the configuration stages until the ”go live” date. A medical representative participated in greater than 98% of all meetings. Results The project was summarised into three phases leading to clinical use as described here. As doctors within the group we draw on our reflections of the process. Planning - This was regularly revised to provide realistic timeframes whilst incorporating the views of participants. The importance of clinical leadership became clear at the infancy to support the project lead, who had a non-clinical background. Collaboration between professionals was essential to create a working list of documents requiring transition to an electronic format. Software configuration - We learnt that sound knowledge of software is essential when designing a system, to identify its limitations and identify its potential. Having a clinical leader present with software expertise is crucial to guide non-clinicians through the process of translating documents to an electronic format. Experience of coding is important, given the complexities of data extraction. Staff training - This created challenges, but the completion of standardised learning objectives was well received alongside role-specific objectives. These are currently utilised for staff induction across all professional groups. Conclusion The process highlighted strong collaborative working practices and recognised the importance of clinical leadership. We identified areas for development, resulting in improved training programmes. A robust and innovative platform has been created for developing future electronic patient records.
A Two Stage Intrusion Detection System for Industrial Control Networks Based on Ethernet/IP

Standard Ethernet (IEEE 802.3 and the TCP/IP protocol suite) is gradually applied in industrial control system (ICS) with the development of information technology. It breaks the natural isolation of ICS, but contains no security mechanisms. An improved intrusion detection system (IDS), which is strongly correlated to specific industrial scenarios, is necessary for modern ICS. On one hand, this paper outlines three kinds of attack models, including infiltration attacks, creative forging attacks, and false data injection attacks. On the other hand, a two stage IDS is proposed, which contains a traffic prediction model and an anomaly detection model. The traffic prediction model, which is based on the autoregressive integrated moving average (ARIMA), can forecast the traffic of the ICS network in the short term and detect infiltration attacks precisely according to the abnormal changes in traffic patterns. Furthermore, the anomaly detection model, using a one class support vector machine (OCSVM), is able to detect malicious control instructions by analyzing the key field in Ethernet/IP packets. The confusion matrix is selected to testify to the effectiveness of the proposed method, and two other innovative IDSs are used for comparison. The experiment results show that the proposed two stage IDS in this paper has an outstanding performance in detecting infiltration attacks, forging attacks, and false data injection attacks compared with other IDSs.
Selective Machine Learning of the Average Treatment Effect with an Invalid Instrumental Variable

Instrumental variable methods have been widely used to identify causal effects in the presence of unmeasured confounding. A key identification condition known as the exclusion restriction states that the instrument cannot have a direct effect on the outcome which is not mediated by the exposure in view. In the health and social sciences, such an assumption is often not credible. To address this concern, we consider identification conditions of the population average treatment effect with an invalid instrumental variable which does not satisfy the exclusion restriction, and derive the efficient influence function targeting the identifying functional under a nonparametric observed data model. We propose a novel multiply robust locally efficient estimator of the average treatment effect that is consistent in the union of multiple parametric nuisance models, as well as a multiply debiased machine learning estimator for which the nuisance parameters are estimated using generic machine learning methods, that effectively exploit various forms of linear or nonlinear structured sparsity in the nuisance parameter space. When one cannot be confident that any of these machine learners is consistent at sufficiently fast rates to ensure $\surd{n}$-consistency for the average treatment effect, we introduce a new criteria for selective machine learning which leverages the multiple robustness property in order to ensure small bias. The proposed methods are illustrated through extensive simulations and a data analysis evaluating the causal effect of 401(k) participation on savings.
Single-Machine Parallel-Batch Scheduling with Nonidentical Job Sizes and Rejection

We investigate the single-machine parallel-batch scheduling problem with nonidentical job sizes and rejection. In this problem, a set of jobs with different processing times and nonidentical sizes is given to be possibly processed on a parallel-batch processing machine. Each job is either accepted and then processed on the machine or rejected by paying its rejection penalty. Preemption is not allowed. Our task is to choose the accepted jobs and schedule them as batches on the machine to minimize the makespan of the accepted jobs plus the total rejection penalty of the rejected jobs. We provide an integer programming formulation to exactly solve our problem. Then, we propose three fast heuristic algorithms to solve the problem and evaluate their performances by using a small numerical example.
Silver cauterization: An office procedure for repair of small tympanic membrane perforation

Introduction: Patients with small tympanic membrane (TM) perforations often suffer from repeated infections rather than hearing loss. Repair of TM perforations is required regardless of its size, as without closure, morbidity may include hearing loss, chronic otorrhea, and cholesteatoma formation. Objective: To assess the effectiveness of the topical silver cauterization to refresh and close small TM perforation as an office-based procedure. Materials and Methods: Thirteen patients with small TM perforations were enrolled in the study. The margin of the perforation was cauterized using silver nitrate 10% that was repeated up to six times. The procedure was considered successful if there was no residual perforation within the follow-up period. Postoperative audiometry was performed before cauterization then at 3 months after. Results: Successful perforation repair was achieved in ten ears (76.9%). Mean hearing gain was 11.5 ± 8 for all cases and 15 ± 5.27 for succeeded cases. None of the patients developed infection, hearing impairment, tinnitus, vertigo, bleeding, taste disturbance, or hyperkeratosis. Conclusion: Office-based silver cautery is a safe, effective, and minimally invasive procedure. It is suitable for repairing small TM perforations with comparable success rate to conventional myringoplasty.