Miracle-dz/UniFAR-FTUs huggingface dataset:
Model-Based Compensation of Topographic Effects for Improved Stem-Volume Retrieval From CARABAS-II VHF-Band SAR Images

A limiting factor that has been identified for stem-volume retrieval in coniferous forests using VHF synthetic aperture radar is that the backscatter varies depending on ground topography. On sloping ground, the backscatter from a forest is reduced, since the dominant ground-trunk double-bounce scattering mechanism is changed. This leads to underestimation of stem volume, and the variations caused by topography can obscure real variations in stem volume. By using multiple images acquired with different flight headings and combining the image information with ground-topography data in a model-based inversion method, we are able to compensate for the ground-topography influence on the backscatter. The inversion method is based on image segmentation and the optimal estimation method. Using four or more images from the CARABAS-II system and a coarse digital elevation model with 50-m horizontal grid, the stem volume can be retrieved with an average root-mean-square error (rmse) of less than 60 m3 ha-1 for stem volumes in range of 80-700 m3 ha-1 (in terms of above-ground biomass, this is equivalent to an rmse of less than 40 ton ldr ha-1 over the range of 50-400 ton ldr ha-1). The retrieval accuracy is similar to that previously obtained for similar forests standing on flat and horizontal ground.
The value of online learning and MRI: Finding a niche for expensive technologies

Abstract Background: The benefits of online learning come at a price. How can we optimize the overall value? Aims: Critically appraise the value of online learning. Methods: Narrative review. Results: Several prevalent myths overinflate the value of online learning. These include that online learning is cheap and easy (it is usually more expensive), that it is more efficient (efficiency depends on the instructional design, not the modality), that it will transform education (fundamental learning principles have not changed), and that the Net Generation expects it (there is no evidence of pent-up demand). However, online learning does add real value by enhancing flexibility, control and analytics. Costs may also go down if disruptive innovations (e.g. low-cost, low-tech, but instructionally sound “good enough” online learning) supplant technically superior but more expensive online learning products. Cost-lowering strategies include focusing on core principles of learning rather than technologies, using easy-to-learn authoring tools, repurposing content (organizing and sequencing existing resources rather than creating new content) and using course templates. Conclusions: Online learning represents just one tool in an educator’s toolbox, as does the MRI for clinicians. We need to use the right tool(s) for the right learner at the right dose, time and route.
[Probiotics in infant formulae. Could we modify the immune response?].

INTRODUCTION The intestinal microflora of breast-fed infants is an important physiological factor in gut function and the development of the immune system. Human milk oligosaccharides have been shown to selectively stimulate the growth of Bifidobacteria and Lactobacilli in the intestine. In the last few years several attempts have been made to establish the presence of similar microbiota in formula-fed infants. One of the approaches to modify the balance of intestinal microflora is to supply the potentially helpful microbiota with selective nutrients (prebiotics). GOAL To review the current scientific evidence related to the addition of prebiotics to infant feeds and their possible role in the immune function. MATERIAL AND METHODS A bibliographic search with Mesh terms: Prebiotics OR oligosaccharides OR intestinal microflora AND infant formula AND results was performed. Special analysis was done on clinical studies. RESULTS Prebiotics are substances that are not absorbed through the small intestine and are fermented by colonic bacteria. A prebiotic mixture from galacto-oligosaccharides and fructo-oligosaccharides has been used to mimic the effect of human milk oligosaccharides. It has been demonstrated that such a mixture significantly increases the number of bifidobacteria in a dose-related way (maximum effect at 0.8 g/dl) and reduces the number of pathogens in term as well as in preterm infants when compared with a group of infants fed a non-supplemented formula. The effect of oligosaccharides on bacterial metabolism was studied by measuring short chain fatty acid production and fecal pH. More recent studies have been able to show clinical benefits with the use of a prebiotic mixture in infant formulas. Firstly, it has been shown to decrease the risk of developing atopic dermatitis in high risk infants; secondly a reduced incidence of intestinal as well as upper airway infections in the first year of life. It can be hypothesized that prebiotics might play an important role as a new concept in allergy and infection prevention in infants.
Semiotic margins : meaning in multimodalities

Introduction, Theo van Leeuwen (University of Technology, Sydney, Australia) Part I: Beyond Paralinguistics Part II: Evolving cartographies in music and space Part III: Intermodality: Theoretical resources for mapping visual verbal relations Part IV: Intermodality: Visual verbal relations and literacy Part V: Imaging representations of meaning 10. Visualising instantiation: Text visualisation techniques for preserving logogenesis, Michele Zappavigna (University of Sydney, Australia) 11. Visualising multimodal patterning, David Caldwell & Michele Zappavigna (University of Sydney, Australia) Conclusion, James R. Martin (University of Sydney, Australia) Index.
Identification of Mycobacterium tuberculosis Clinical Isolates with Altered Phagocytosis by Human Macrophages Due to a Truncated Lipoarabinomannan*

Phenotypically distinct clinical isolates of Mycobacterium tuberculosis are capable of altering the balance that exists between the pathogen and human host and ultimately the outcome of infection. This study has identified two M. tuberculosis strains (i.e. HN885 and HN1554) among a bank of clinical isolates with a striking defect in phagocytosis by primary human macrophages when compared with strain Erdman, a commonly used laboratory strain for studies of pathogenesis. Mass spectrometry in conjunction with NMR studies unequivocally confirmed that both HN885 and HN1554 contain truncated and more branched forms of mannose-capped lipoarabinomannan (ManLAM) with a marked reduction of their linear arabinan (corresponding mainly to the inner Araf-α(1→5)-Araf unit) and mannan (with fewer 6-Manp residues and more substitutions in the linear Manp-α(1→6)-Manp unit) domains. The truncation in the ManLAM molecules produced by strains HN885 and HN1554 led to a significant reduction in their surface availability. In addition, there was a marked reduction of higher order phosphatidyl-myo-inositol mannosides and the presence of dimycocerosates, triglycerides, and phenolic glycolipid in their cell envelope. Less exposed ManLAM and reduced higher order phosphatidyl-myo-inositol mannosides in strains HN885 and HN1554 resulted in their low association with the macrophage mannose receptor. Despite reduced phagocytosis, ingested bacilli replicated at a fast rate following serum opsonization. Our results provide evidence that the clinical spectrum of tuberculosis may be dictated not only by the host but also by the amounts and ratios of surface exposed mycobacterial adherence factors defined by strain genotype.
Editorial –In this Issue: Innate Immunity in Normal and Pathologic Circumstances

In this issue of the International Reviews of Immunology, we host several reviews dedicated to the innate immunity in normal and diseased states. Tan et al. discuss the molecular nature of the innate immune response as a consequence of co-engagement of distinct Toll-like receptors. Schwarz et al. present a regulatory loop leading to increased myelopoiesis through the engagement of CD137L by CD137+ T cells. Kolandaswamy et al. present transcriptomic evidence that distinguishes between two major subsets of monocytes. In a different review, Minasyan presents an interesting hypothesis that erythrocytes have a dominant role in clearing bacteria within the blood stream while leukocytes’ role is mostly extra-vascular. Yan et al. discuss the pivotal role of the liver, its pre-existing and associated pathology, in sepsis. Zhang outlines the implications of declining neutrophils and impact to long-term management of HIV-associated disease. Finally, Lal et al. discuss the multiple roles of γδT cells in innate and adaptive immunity.
Citations and the h index of soil researchers and journals in the Web of Science, Scopus, and Google Scholar

Citation metrics and h indices differ using different bibliometric databases. We compiled the number of publications, number of citations, h index and year since the first publication from 340 soil researchers from all over the world. On average, Google Scholar has the highest h index, number of publications and citations per researcher, and the Web of Science the lowest. The number of papers in Google Scholar is on average 2.3 times higher and the number of citations is 1.9 times higher compared to the data in the Web of Science. Scopus metrics are slightly higher than that of the Web of Science. The h index in Google Scholar is on average 1.4 times larger than Web of Science, and the h index in Scopus is on average 1.1 times larger than Web of Science. Over time, the metrics increase in all three databases but fastest in Google Scholar. The h index of an individual soil scientist is about 0.7 times the number of years since his/her first publication. There is a large difference between the number of citations, number of publications and the h index using the three databases. From this analysis it can be concluded that the choice of the database affects widely-used citation and evaluation metrics but that bibliometric transfer functions exist to relate the metrics from these three databases. We also investigated the relationship between journal’s impact factor and Google Scholar’s h5-index. The h5-index is a better measure of a journal’s citation than the 2 or 5 year window impact factor.
Genetic determinants of the stress response in cardiovascular disease.

Originating from Hans Selye's general concept, the biological notion of the stress response implicates neuroendocrine and endocrine pathways as well as their cellular mediators as components of the general adaptation syndrome and its consequences. A highly variable degree of response to psychological and physical stresses has been noted in experimental animals and in human populations. Some stressors, such as the "cold pressor test," have been developed as tools for disease prediction. They apply to variable conditions, from hypertension to insulin resistance, but mostly in relation to cardiovascular outcomes. Other environmental factors, including the degree of salt intake, potentiate the stress response in animals and humans. Our group has undertaken to explore the genetic determinants of the stress response in inbred strains, recombinant congenic and congenic strains, as well as founder human populations. We have succeeded, initially, in linking increased body temperature, a major phenotypic response to stress, to the quantitative trait loci (QTL), one at myh3 on chromosome (Chr) 10, one at hsp27 on Chr 12, and one on Chr Y in the rat. The expression of several stress proteins is under the dominant influence of hstf1 at the rat Chr 7 locus (Mit3). The high prevalence of cardiovascular diseases with traits of enhanced stress responsiveness is discussed here in the context of a paradigm, such as hypertension, in the general population.
Aggregation of energetic flexibility using zonotopes

The importance of energetic flexibility of distributed energy resources grows with the share of renewable generation in the power grid. However, the quantitative description and aggregation of flexible resources is challenging. This work proposes the use of zonotopes, a subclass of polytopes, to approximate flexibility. It is shown how optimal zonotopic approximations of flexibility can be computed efficiently for different objectives, and that the aggregation of those sets is tractable with regard to memory and computational complexity for long planning horizons and large populations of systems. In addition, we describe synergistic behavior exhibited by the aggregation of flexibility and illustrate that zonotopes can partly capture these synergy effects.
THE EFFECTS OF VARIED REST PERIODS BETWEEN SETS TO FAILURE USING THE BENCH PRESS IN RECREATIONALLY TRAINED MEN

The purpose of this study was to determine the rate of recovery for recreational weight trainers between 2 sets of bench press to volitional exhaustion. Twenty-eight men performed 2 sets of the bench press at 75% of their previously determined 1 repetition maximum (1RM) to volitional exhaustion. Rest periods of 1, 3, or 5 minutes between sets were utilized on the 3 separate testing days. There was a significant decrease in the number of repetitions performed between the second sets at all rest periods. There were no significant differences in work performed (repetitions × weight) during the second set with the 3- and 5-minute rest periods, but the total work with a 1-minute rest period (1,389.1 ± 529.9) was significantly less than both the 3- (1,494.9 ± 451.0) and 5-minute (1,711.4 ± 478.0) rest period. The data indicated that subjects were unable to fully recover between the first and second sets of maximal resistance exercise, regardless of the rest period. However, subjects were able to maintain a performance level of 8–12 repetitions and sustain the total work performed per set with as little as 3 minutes rest between sets.
Evolution of Human and Non-human Primate CC Chemokine Receptor 5 Gene and mRNA

Polymorphisms in CC chemokine receptor 5 (CCR5), the major coreceptor of human immunodeficiency virus 1 (HIV-1) and simian immunodeficiency virus (SIV), have a major influence on HIV-1 transmission and disease progression. The effects of these polymorphisms may, in part, account for the differential pathogenesis of HIV-1 (immunosuppression) and SIV (natural resistance) in humans and non-human primates, respectively. Thus, understanding the genetic basis underlying species-specific responses to HIV-1 and SIV could reveal new anti-HIV-1 therapeutic strategies for humans. To this end, we comparedCCR5 structure/evolution and regulation among humans, apes, Old World Monkeys, and New World Monkeys. The evolution of theCCR5 cis-regulatory region versus the open reading frame as well as among different domains of the open reading frame differed from one another. CCR5 cis-regulatory region sequence variation in humans was substantially higher than anticipated. Based on this variation, CCR5 haplotypes could be organized into seven evolutionarily distinct human haplogroups (HH) that we designated HHA, -B, -C, -D, -E, -F, and -G. HHA haplotypes were defined as ancestral to all other haplotypes by comparison to theCCR5 haplotypes of non-human primates. Different human and non-human primate CCR5 haplotypes were associated with differential transcriptional regulation, and various polymorphisms resulted in modified DNA-nuclear protein interactions, including altered binding of members of the NF-κB family of transcription factors. We identified novel CCR5 untranslated mRNA sequences that were conserved in human and non-human primates. In some primates, mutations at exon-intron boundaries caused loss of expression of selected CCR5 mRNA isoforms or production of novel mRNA isoforms. Collectively, these findings suggest that the response to HIV-1 and SIV infection in primates may have been driven, in part, by evolution of the elements controlling CCR5 transcription and translation.
Evidence-based Value of Prophylactic Drainage in Gastrointestinal Surgery: A Systematic Review and Meta-analyses

Objective:To determine the evidence-based value of prophylactic drainage in gastrointestinal (GI) surgery. Methods:An electronic search of the Medline database from 1966 to 2004 was performed to identify articles comparing prophylactic drainage with no drainage in GI surgery. The studies were reviewed and classified according to their quality of evidence using the grading system proposed by the Oxford Centre for Evidence-based Medicine. Seventeen randomized controlled trials (RCTs) were found for hepato-pancreatico-biliary surgery, none for upper GI tract, and 13 for lower GI tract surgery. If sufficient RCTs were identified, we performed a meta-analysis to characterize the drain effect using the random-effects model. Results:There is evidence of level 1a that drains do not reduce complications after hepatic, colonic, or rectal resection with primary anastomosis and appendectomy for any stage of appendicitis. Drains were even harmful after hepatic resection in chronic liver disease and appendectomy. In the absence of RCTs, there is a consensus (evidence level 5) about the necessity of prophylactic drainage after esophageal resection and total gastrectomy due to the potential fatal outcome in case of anastomotic and gastric leakage. Conclusion:Many GI operations can be performed safely without prophylactic drainage. Drains should be omitted after hepatic, colonic, or rectal resection with primary anastomosis and appendectomy for any stage of appendicitis (recommendation grade A), whereas prophylactic drainage remains indicated after esophageal resection and total gastrectomy (recommendation grade D). For many other GI procedures, especially involving the upper GI tract, there is a further demand for well-designed RCTs to clarify the value of prophylactic drainage.
Maintaining multiple sclerosis patients' quality of life: a case study on environment control assistance in a smart home

This paper presents a case study on how smart-home technology can improve the quality of life for multiple sclerosis patients by implementing personalized environment control assistance. We developed a prototype that allows users with diminished motoric skills to use voice recognition software on a smartphone to control a house's front door, lights, telephone, TV and PC. We focused on affordable hardware and open-source software to maximize adaptability and extensibility, which is required for individual solutions. The development followed a user-centric design process, where a group of 10 multiple sclerosis patients participated in workshops to assess their requirements and evaluate the usability of the implemented prototype.
Therapeutic drugs in the treatment of symptomatic uterine fibroids

Introduction: The therapy of symptomatic uterine fibroids is based on surgery in the majority of cases. Conservative medical treatment in cases of contraindication against operative treatment, bleeding control or preoperative down-sizing of the fibroids is classically based on sex steroid depletion by gonadotropin-releasing hormone (GnRH) agonist administration for a prolonged period. However, this approach is associated with often severe climacteric side effects and fibroids quickly relapse after treatment cessation. Furthermore, the achievement of menstrual bleeding control has been tried by administration of combined oral contraceptives, progestins or the levonorgestrel-releasing intrauterine device. These approaches, however, are not associated with a significant reduction in fibroid volume. Areas covered: With the introduction of Ulipristal acetate (UPA), a new selective progesterone receptor modulator (SPRM) is now licensed for the preoperative treatment of fibroids. The administration should be limited to 3 months. UPA induces amenorrhea within a relatively short term of – on average – 7 days and may thus reduce fibroid-induced anemia. Furthermore, a significant reduction of the fibroid volume persisting after cessation of the treatment could be demonstrated for UPA. Herein, a review of the current therapeutic options for conservative and preoperative medical fibroid treatment is given and the clinical utility of UPA is outlined. Expert opinion: In contrast to precedent myoma medication, volume reduction of the fibroids persists several months after cessation of UPA-administration. UPA optimizes operative conditions and thus the postoperative outcome by reducing anemia and down-sizing of fibroids.
Genome size variation and evolution in Veronica.

BACKGROUND AND AIMS The amount of DNA per chromosome set is known to be a fairly constant characteristic of a species. Its interspecific variation is enormous, but the biological significance of this variation is little understood. Some of the characters believed to be correlated with DNA amount are alpine habitat, life history and breeding system. In the present study, the aim is to distinguish between direct causal connections and chance correlation of the amount of DNA in the genus Veronica. METHODS Estimates of DNA amount were analysed for 42 members of Veroniceae in connection with results from a phylogenetic analysis of plastid trnL-F DNA sequences and tested correlations using standard statistical tests, phylogenetically independent contrasts and a model-based generalized least squares method to distinguish the phylogenetic effect on the results. KEY RESULTS There appears to be a lower upper limit for DNA amount in annuals than in perennials. Most DNAC-values in Veroniceae are below the mean DNA C-value for annuals in angiosperms as a whole. However, the long-debated correlation of low genome size with annual life history is not significant (P = 0.12) using either standard statistical tests or independent contrasts, but it is significant with the generalized least squares method (P < 0.01). CONCLUSIONS The correlation of annual life history and low genome size found in earlier studies could be due to the association of annual life history and selfing, which is significantly correlated with low genome size using any of the three tests applied. This correlation can be explained by models showing a reduction in transposable elements in selfers. A significant correlation of higher genome sizes with alpine habitats was also detected.
Efficient Collision Culling among Deformable Objects using Graphics Processors

We present a fast collision culling algorithm for performing inter- and intra-object collision detection among complex models using graphics hardware. Our algorithm utilizes visibility queries on the GPUs to eliminate a subset of geometric primitives that are not in close proximity and computes a potentially colliding set (PCS) of primitives. We perform no precomputation and the algorithm proceeds in multiple stages: object-level PCS computation, subobject level PCS computation, followed by exact collision detection. We extend our PCS computation algorithm to perform intra-object or self-collisions between complex models. Furthermore, we describe a novel visibility-based classification scheme to reduce the size of potentially-colliding sets of objects and primitives, and the number of visibility queries for further improving the performance and culling efficiency. We have implemented our algorithm on a PC with an NVIDIA GeForce FX 6800 Ultra graphics card and applied it to three complex simulations, each consisting of objects with tens of thousands of triangles. In practice, we are able to compute all the self-collisions for cloth simulation up to image-space precision at interactive rates.