Miracle-dz/UniFAR-FTUs huggingface dataset:
Clonage de la mutation responsable de la surproduction de sterols chez un mutant de tabac (nicotiana tabacum)

Le mutant de tabac lab 1-4 a ete selectionne pour sa resistance, a l'etat de cal, au triazole herbicide lab 170250f. Ce mutant accumule 10 fois plus de sterols que le tabac sauvage. Des resultats preliminaires ont montre que chez ce mutant, l'activite 3-hydroxy-3-methylglutaryl coenzyme a reductase (hmgr) est augmentee. Nous avons montre qu'alors que les k#m vis-a-vis du 3-hydroxy-3-methylglutaryl coenzyme a etaient semblables pour les tabacs de genotypes sauvage et mutant, la v#m#a#x etait 5 a 6 fois superieure pour le mutant lab 1-4. Au vu de ces resultats, les quantites de proteines hmgr detectees par western blot etant equivalentes pour les deux genotypes de tabac, nous avons privilegie l'hypothese que la mutation a l'origine du phenotype lab 1-4 porte directement sur une proteine hmgr. Ainsi, afin de determiner l'origine moleculaire de la surproduction de sterols, nous avons clone des adnc codant pour l'hmgr a partir de banques de cals de tabac de genotypes lab 1-4 et sauvage. Nous avons obtenu une sequence specifique au genotype lab 1-4 dans laquelle un residu de proline est remplace par une serine. L'expression de cet adnc dans une souche de levure deficiente en activite hmgr n'a revele aucune difference d'activite hmgr par rapport aux activites des produits des autres adnc. Cependant dans des tabacs transgeniques exprimant l'adnc specifique au genotype lab 1-4 la composition sterolique mesuree est voisine de celle du mutant lab 1-4 et suggere que la mutation ponctuelle sur le nouvel adnc soit la mutation lab 1-4.
On the Security of a Key Agreement and Key Protection Scheme

We point out that the key agreement and key protection scheme (published in IEEE Transactions on Information Forensics and Security, doi: 10.1109/TIFS.2018.2850299) fails to achieve the two-factor security. We demonstrate that in the scheme, if an adversary can control the master device of a target user, he can impersonate the user to pass the server’s authentication.
How peer support can assist job-seekers with a disability move into work

Abstract Anecdotally, there are frequent reports that peer-facilitated initiatives can be successfully used in employment services. However, in Australia, there is little information about how to effectively deliver peer support. In this paper, we discuss how peer-based interventions might be used to supplement formal return-to-work services and contribute to positive job-seeking outcomes. We illustrate the potential of vocational peer support using a real situation involving a young adult who successfully returned to work soon after sustaining a traumatic injury. Future research should explore the inclusion of various peer support structures and formats as a component of other employment services, to help people with long-term conditions and disabilities achieve a range of vocational outcomes and to guide practice in this area.
MOTIVATIONAL AND VALUE PREFERENCES OF TOWNSPEOPLE IN THE FIELD OF FITNESS

The article presents the results of a survey of Odessa (Ukraine) residents as part of a study of the motivational and value preferences of townsfolk in the field of fitness. It has been established that the determining motives for choosing a place for fitness are the individual trainer's approach to the client, personal comfort and convenient location of the fitness club. It was revealed that respondents have an interest in innovative training, but it has not yet acquired the character of a trend. We also obtained data about the significance of playing sports under the supervision of a personal trainer and sports physician. The collected empirical material served as the basis for revealing the behavioral patterns of townspeople and allowed to identify three groups of city residents who are characterized by different motivational and value preferences in the field of fitness. The first ones are focused on personal achievements, the second – on health, good physical form, good time among likeminded people, the third – on the development of special skills, achievements and opportunities to escape from problems. Based on the survey, it was also revealed that the overall physical development of the child is the leading physical motivation for children to do sports, and despite the fact that children may have certain achievements in sports, parents do not attach much importance to them.
Red emissive carbon dots obtained from direct calcination of 1,2,4-triaminobenzene for dual-mode pH sensing in living cells

Real-time monitoring of intracellular pH is urgently required for studying cell metabolism and apoptosis. Carbon dot-based fluorescence probes are the most likely candidates to fulfil such an application, as they possess excellent chemical inertness, low cytotoxicity, high resistance to photobleaching, good biocompatibility, and tuneable emission wavelength. Our research program aims to develop tailor-designed red emissive carbon dots (r-CDs) using technology innovations in synthetic strategies. The r-CDs showing responses to pH were prepared through direct calcination of 1,2,4-triaminobenzene as the only carbon source. Measurements of fluorescent emission wavelength and quantum yield were carried out to optimize the carbonized temperature and heating time. The obtained r-CDs can sensitively respond to pH both in colorimetric and fluorometric modes, namely, with the increase of pH from 4.0 to 8.0, the color of the r-CD solution under ambient light changed from red to orange and then to yellow, and the corresponding fluorescence varied from purple to orange then to yellow under UV irradiation, which can be easily observed by the naked eye. Experimental characterization along with density functional theory (DFT) simulation study reveal that the pH response originates from the reversible transformation between azo and quinone structures during the protonation process. This solid-state preparation is not only simple in procedures and ready to scale up production, more significantly the resulting r-CDs exhibit a number of distinct advantages, and have great potential for biological sensing applications.
The Rationale Behind Texting, Videoconferencing, and Mobile Phones in Couple Relationships

Abstract Smartphones and digital media are omnipresent in day-to-day life. There are positive and negative consequences to technology usage in established relationships; we also know that there are several theories outlining why people use technology generally. What is less clear, however, is how these two entities intersect. The purpose of this article is to determine the how different mechanisms related to technology—namely, texting, video calling, and e-mail—are used in established romantic relationships. Using a hermeneutics qualitative methodology and interviewing 17 individuals, we uncovered the rationale for why individuals decide on using particular methods of communication to engage with their romantic partner. We discovered unique reasons for texting as compared to video conferences, phone calls, and e-mail usage in established romantic relationships. Implications and future research are discussed.
Mixed discrete‐continuous regression—A novel approach based on weight functions

In a wide range of applications, standard regression techniques are hard to apply because the responses may consist of a continuous part but augmented with a discrete number of additional response categories with probability greater than zero. Previous methods often assume that the process of both parts can be treated structurally independent given covariates which facilitates estimation considerably. However, this simplifying assumption is often too restrictive and questionable for the data situation at hand. To address this, we propose a novel approach for modelling mixed discrete‐continuous responses where the probabilities of the boundary cases are based on integrated weighted densities of the continuous part. The weight functions themselves may depend on covariates as well as unknown parameters. We discuss different types of mixed discrete‐continuous distributions and consider inferential methods in a Bayesian and maximum likelihood framework. We evaluate parameter estimation carefully in simulation studies before applying them to the analysis of income distributions using a specific instance of the novel zero‐adjusted‐type model.
El capital intelectual y la generación de conocimiento en las universidades públicas colombianas

La literatura del capital intelectual en educacion ha proporcionado evidencia de un creciente interes academico en esta area como un campo relevante de investigacion. Sin embargo, en Colombia son pocos los trabajos y son aun mas escasos en el sector de la educacion superior. De hecho, los enfoques de medicion propuestos se han desarrollado en su gran mayoria en el contexto europeo, lo que hace dificil su adaptacion y aplicacion en universidades colombianas. Asimismo, los estudios de caracter empirico sobre la naturaleza de las interrelaciones entre las dimensiones del capital intelectual (capitales humano, estructural y relacional) y su efecto en el desempeno de las universidades, no han arrojado las evidencias suficientes. Por lo tanto, la presente investigacion tiene como proposito contribuir a abordar esta brecha mediante la propuesta de un marco de medicion del capital intelectual, enfocado en las capacidades y el desempeno de la investigacion en universidades publicas colombianas. Igualmente, analizar las interrelaciones entre las dimensiones del capital intelectual y su efecto sobre la generacion de conocimiento. Para alcanzar estos objetivos, se realiza en la primera fase del estudio un analisis cuantitativo y longitudinal basado en estudios de casos multiples. En la segunda etapa, se emplean los modelos de ecuaciones estructurales para comprobar la validez y ajuste del modelo propuesto. Los hallazgos resaltan la relevancia del marco de medicion del capital intelectual en la funcion de identificar el desarrollo de las capacidades y el desempeno de la investigacion, permitiendo visualizar de manera integral y sistematica los logros alcanzados. Las hipotesis que proponen una asociacion positiva entre las dimensiones del capital intelectual y la generacion de conocimiento fueron probadas. En particular, el capital humano esta relacionado indirectamente de forma positiva con la generacion de conocimiento a traves del capital relacional, asi como tambien por la via del capital estructural-capital relacional. De este modo, la presente investigacion contribuye a los dos enfoques de estudio del capital intelectual en las universidades Palabras clave: Capital intelectual, Educacion superior, Desempeno de la Investigacion, Universidades publicas colombianas
MORPHOMETRY AND HISTOPATHOLOGY OF BROILER CHICKENS FED GINGER BY-PRODUCT MEAL TREATED WITH EXOGENOUS ENZYME

Background. It has been reported that feeding of dried fermented ginger increased intestinal villus height, villus area, and cell area in broiler chickens. It has been reported that essential oils originating from plants have antimicrobial activity which have toxic effects in poultry when administered at very high doses. Hypothesis. Toxins may destroy some organs immediately (intra- cellular) or later (extracellular) affecting either biochemical functions or structure of organs depending on the dosage and therapy. Methodology. An experiment was conducted to evaluate morphometry and histopathology of chickens fed Ginger By-product Meal (GBM) diets. In this experiment, GBM was supplemented with a multi enzyme preparation (Maxigrain©), using 270 broiler chicks allocated to six experimental diets (0, 15 and 30% GBM; 0 and 0.01% enzyme) in a completely randomized design for eight weeks. Results. The inclusion of GBM had a significant effect (P < 0.05) on the weight of intestine, gizzard, intestinal length and abdominal fat. The weight of the gizzard increased while the abdominal fat decreased. There was also an increase in the length and weight of the intestine. Enzyme supplementation brought about a significant (P < 0.05) decrease in the weight of the breast but a significant (P < 0.05) increase in the weight and length of the intestine. Conclusion. The diets had no negative effect on most of the organs except the intestine where there was sloughing of the micro-villi caused by GBM and enzyme.
Spatially Adaptive Regularizer for Mesh Denoising

Mesh denoising is a fundamental yet not well-solved problem in computer graphics. Many existing methods formulate the mesh denoising as an optimization problem, whereby the optimized mesh could best fit both the input and a set of constraints defined as an <inline-formula> <tex-math notation="LaTeX">$L_{p}$ </tex-math></inline-formula> norm regularizer. Instead of setting <inline-formula> <tex-math notation="LaTeX">$p$ </tex-math></inline-formula> as a static value for the whole surface, we adopt a dynamic <inline-formula> <tex-math notation="LaTeX">$L_{p}$ </tex-math></inline-formula> regularizer which imposes two different forms of regularization onto different surface patches for a better understanding of the local surface features. To help determine the appropriate <inline-formula> <tex-math notation="LaTeX">$p$ </tex-math></inline-formula> value for each facet, the guidance is constructed dynamically in a patch-based manner. We compare the proposed method with state-of-the-arts in both synthetic and real-scanned benchmark datasets, and show that the proposed method could produce comparable results to neural network based mesh denoising method, without collecting large training datasets.
Detection of skin Cancer using PIFA antenna

Due to the advancements in electromagnetic fields, it can be widely used in medical applications to detect various diseases. In this paper we present a novel idea to detect a biological skin cancer tissue by designing a Planar Inverted F antenna (PIFA) which is more commonly available in mobile devices. Our basic idea is to design PIFA antenna using CST software and thereby fabricating the antenna with one port and identifying its reflection parameters and VSWR ratio. The Biological skin tissue is modelled in CST software by using the dielectric properties of a normal tissue and a cancerous tissue. The antenna is excited by a source and radiated towards the normal and affected skin tissue. The permittivity, Conductivity, permeability and absorption power by the skin tissues are identified and compared with the affected tissues. Results showed that the Energy received from the normal and affected skin tissues gets varied and from this simulation results we can be able to conclude that weather a cancerous tissue is present in a human body.
HGFM : A Hierarchical Grained and Feature Model for Acoustic Emotion Recognition

To solve the problem of poor classification performance of multiple complex emotions in acoustic modalities, we propose a hierarchical grained and feature model (HGFM). The frame-level and utterance-level structures of acoustic samples are processed by the recurrent neural network. The model includes a frame-level representation module with before and after information, a utterance-level representation module with context information, and a different level acoustic feature fusion module. We take the output of frame-level structure as the input of utterance-level structure and extract the acoustic features of these two levels respectively for effective and complementary fusion. Experiments show that the proposed HGFM has better accuracy and robustness. By this method, we achieve the state-of-the-art performance on IEMOCAP and MELD datasets.
Pleomorfismos en cepas de Trypanosoma rangeli aisladas de Rhodnius colombiensis y R. pallescens

Trypanosoma rangeli infecta gran variedad de mamiferos silvestres y domesticos, incluyendo al hombre. En varios paises latinoamericanos se han descrito recientemente dos subpoblaciones denominadas KP1(+) y KP1(-), cuya caracterizacion biologica y molecular es objeto de investigacion. Para evaluar la variabilidad biologica en la subpoblacion KP1(-) se inocularon ratones ICR con epimastigotes de cultivo de cuatro cepas aisladas de Rhodnius pallescens y R. colombiensis. Se prepararon extendidos de sangre, se colorearon con Giemsa al tercer, quinto y septimo dia pos-inoculacion, a partir de los cuales se dibujaron en camara clara 29 parasitos de cada cepa y para cada dia; de esa manera se efectuaron mediciones de los siguientes parametros morfologicos: longitud total (L), longitud del flagelo libre (F), distancia del extremo posterior al cinetoplasto (PK), distancia del nucleo al cinetoplasto (KN), distancia del extremo posterior al nucleo (PN), distancia del extremo anterior al nucleo (NA), indice nuclear (IN) e indice del cinetoplasto (IK). El analisis de las cepas aisladas de los vectores mostro dos grupos morfometricamente diferentes: un grupo conformado por las cepas aisladas de R. pallescens y otro conformado por las cepas aisladas de R. colombiensis. La evaluacion de la longitud total y la longitud del flagelo durante los dias 3, 5 y 7 pos-inoculacion constituye una evidencia mas de la alta variabilidad existente entre las cepas de T. rangeli aisladas de R. pallescens y R. colombiensis, pues se demostro que los perfiles de estas variables no son paralelos ni coincidentes. Estos estudios de variabilidad morfologica tienen importancia para el diagnostico y la determinacion taxonomica de las poblaciones de T. rangeli.
Rôle des glucosaminyl sulfotransférases dans la biosynthèse de motifs héparanes sulfates impliqués dans la fixation et l’activité de facteurs inflammatoires

Les heparanes sulfates (HS) sont synthetises a partir d’un precurseur non sulfate, forme de la repetition du disaccharide [GlcUA s1,4 GlcNAc]. Ce precurseur est ensuite modifie par des enzymes de maturation, N-deacetylase/N-sulfotransferases (NDSTs), O-sulfotransferases (OSTs) et C5-epimerase. Ces enzymes, dont l’expression est dependante du type cellulaire, possedent des activites et des specificites de substrat differentes, ce qui confere une grande heterogeneite structurale aux HS et offre un large eventail de motifs de fixation pour les proteines. Il est clairement etabli que les proteoglycanes a chaines HS regulent la fixation et l'activite de nombreux facteurs inflammatoires. En revanche, peu d'informations sont disponibles sur la nature de leurs motifs HS de fixation. L’objectif de ces travaux a ete de relier les variations d'expression des glucosaminyl sulfotransferases a la generation de motifs HS specialises dans la fixation des facteurs inflammatoires
Parasitosis intestinal en pacientes infectados con el virus de inmunodeficiencia humana

Los pacientes infectados con el Virus de Inmunodeficiencia Humana (VIH) padecen trastornos gastrointestinales. El objetivo de este estudio fue determinar la prevalencia de parasitos intestinales en individuos infectados por el VIH en el Complejo Hospitalario Universitario “Ruiz y Paez”, estado Bolivar, Venezuela; donde no existian estudios previos. Se obtuvieron muestras de heces de pacientes con diagnostico confirmado de infeccion por el VIH en un periodo de 12 meses. Se estudiaron tres muestras seriadas realizando examen directo ymetodos de concentracion: sedimentacion por Formol-Eter, flotacion de Willis y Harada-Mori. Ademas, tincion de Kinyoun, Tricromica para Microsporidium y observacion de la muestra mediante fluorescencia directa. Fueron diagnosticados: Blastocystis hominis (85,7%), Entamoeba coli (77,1%) y Endolinax nana (37,1%). Cryptosporidium parvum se demostro en 7 pacientes con SIDA; Cyclospora cayetanensis en 3 pacientes, 2 de los cuales padecian el SIDA y Microsporidium spp en 4 pacientes (11,4%). Hubo asociacion estadisticamente significativa entre diarrea y la presencia de Coccidios y Microsporidium spp (p<0,05). Los helmintos demostrados fueron: Ascaris lumbricoides (14,3%), Ancylostomideos y Trichuris trichiura (5,7%). El unico cestodo fue Hymenolepis diminuta (5,7%). Las para- sitosis intestinales son frecuentes en pacientes infectados con VIH en el estado Bolivar, siendo la blastocistosis y las infecciones por coccidios las prevalentes.
Hybridized Intelligent Home Renewable Energy Management System for Smart Grids

The incorporation of renewable energies and power storage at distribution facilities are one of the important features in the smart grid. In this paper, a hybridized intelligent home renewable energy management system (HIHREM) that combines solar energy and energy storage services with the smart home is planned based on the demand response and time of consumption pricing is applied to programs that offer discounts to consumers that reduce their energy consumption during high demand periods. The system is designed and handled with minimal energy requirements at home through installation of renewable energy, preparation, and arrangement of power stream during peak and off-peak periods. The best energy utilization of residential buildings with various overlapping purposes is one of the most difficult issues correlated with the implementation of intelligent micro-network systems. A major component of the smart grid, the domestic energy control system (HIHREM) provides many benefits, such as power bill reductions, reduction in wind generation, and demand compliance. This showed that the proposed energy scheduling method minimizes the energy consumption by 48% and maximizes the renewable energy consumed at the rate 65% of the total energy generated. A new model for smart homes with renewable energies is introduced in this report. The proposed HIHREM method achieves high performance and reduces cost-utility.
The complete chloroplast genome sequence of Heracleum yungningense

Abstract Heracleum yungningense is a traditional medicinal plant widely used in China. Here, we reported the complete chloroplast genome of H. yungningense using Illumina paired-end sequencing. The whole genome is 149,223 bp in length, which contains a pair of 18,496 bp inverted repeats regions separated by a large single-copy region and a small single-copy region with 94,770 bp and 17,461 bp in length, respectively. Additionally, the cp genome of H. yungningense contains 113 genes, including 80 protein-coding genes, 29 transfer RNAs, and 4 ribosomal RNAs. The GC content of this cp genome is 37.5%. Phylogenetic analysis was conducted to assess inter-relationships among the major clades of Apiaceae, which strongly supported the close relationship of H. yungningense and H. moellendorffii.
Road Tunnel Detection Robot and Method Based on Laser Point Cloud

The maintenance of road tunnels is more important, and there are problems such as water seepage, surface cracking and falling off. If it cannot be detected and handled in time, it will pose a major threat to the driving safety of road vehicles. Therefore, this paper proposes a road tunnel defect detection scheme based on laser point cloud. Firstly, a robot for road detection is developed. Secondly, a road defect detection method based on laser point cloud is developed. Laser SLAM technology is used to reconstruct dense point clouds in road tunnel scenes. Finally, through the automatic detection of the three-dimensional reconstruction scene of the tunnel, the defects such as cracks and spalling of the road tunnel are automatically identified. Compared with the visual detection scheme, this method does not depend on the problem of ambient light and has better robustness and practicability.