Miracle-dz/UniFAR-FTUs huggingface dataset:
Polychlorinated biphenyls PCDF Polychlorinated dibenzofurans PPE Personal protective equipment SMR Standardized mortality ratio SRR Standardized relative risk TCE Trichloroethylene

We developed a semiquantitative job exposure matrix (JEM) for workers exposed to polychlorinated biphenyls (PCBs) at a capacitor manufacturing plant from 1946 to 1977. In a recently updated mortality study, mortality of prostate and stomach cancer increased with increasing levels of cumulative exposure estimated with this JEM (trend p values=0.003 and 0.04, respectively). Capacitor manufacturing began with winding bales of foil and paper film, which were placed in a metal capacitor box (preassembly), and placed in a vacuum chamber for floodfilling (impregnation) with dielectric fluid (PCBs). Capacitors dripping with PCB residues were then transported to sealing stations where ports were soldered shut before degreasing, leak testing, and painting. Using a systematic approach, all 509 unique jobs identified in the work histories were rated by predetermined processand plant-specific exposure determinants; then categorized based on the jobs’ similarities (combination of exposure determinants) into 35 job exposure categories. The job exposure categories were ranked followed by a qualitative PCB exposure rating (baseline, low, medium, and high) for inhalation and dermal intensity. Category differences in other chemical exposures (solvents, etc.) prevented further combining of categories. The mean of all available PCB concentrations (1975 and 1977) for jobs within each intensity rating was regarded as a representative value for that intensity level. Inhalation (in microgram per cubic milligram) and dermal (unitless) exposures were regarded as equally important. Intensity was frequency adjusted for jobs with continuous or intermittent PCB exposures. Era-modifying factors were applied to the earlier time periods (1946–1974) because exposures were considered to have been greater than in later eras (1975– 1977). Such interpolations, extrapolations, and modifying factors may introduce non-differential misclassification; however, we do believe our rigorous method minimized misclassification, as shown by the significant exposure– response trends in the epidemiologic analysis.
Time Update Key secure channel public channel Verifier Signature Identity : Message : Time Period : Signing key : Identity : Message : Time Period : MTK

Over the last few years, identity-based cryptosystem (IBC) has attracted widespread attention because it avoids the high overheads associated with public key certificate management. However, an unsolved but critical issue about IBC is how to revoke a misbehaving user. There are some revocable identity-based encryption (IBE) schemes that have been proposed recently, but little work on the revocation problem of identitybased signature has been undertaken so far. One approach for revocation in identity-based settings is to update users’ private keys periodically, which is usually done by the key generation center (KGC). But with this approach, the load on the KGC will increase quickly when the number of users increases. In this work, we propose an efficient revocable identity-based signature (RIBS) scheme in which the revocation functionality is outsourced to a cloud revocation server (CRS). In our proposed approach, most of the computations needed during key-updates are offloaded to the CRS. We describe the new framework and the security model for the RIBS scheme with CRS and we prove that the proposed scheme is existentially unforgeable against adaptively chosen messages and identity attacks in the random oracle model. We further demonstrate that our scheme outperforms previous IBS schemes in terms of lower computation and communication costs.
Protective Potential of High Molecular Weight Outer Membrane Protein of Pasteurella multocida Type

Iron-regulated outer membrane proteins (OMPs) of Pasteurella multocida have been shown previously to elicit superior protective immunity. We have identified that high molecular weight OMP 116 kDa was expressed when Pasteurella multocida type 6:B was grown under iron-restricted condition. The highly purified 116 kDa protein was found to be only 60% protective to mice against experimental pasteurellosis. Two other proteins with high molecular weight (MW) (87 and 71 kDa) were shown to be expressed slightly more when grown under iron-restricted condition; however, the protection afforded by 87 kDa protein was is only 40%.
Estimation of spatial distribution and temporal variability of land surface temperature over Casablanca and the surroundings of the city using different Landat satellite sensor type (TM, ETM+ and OLI)

Over the last few decades, Casablanca city became the biggest industrial, commercial center in Morocco with rapid urbanization and explosive population growth, more than 4 million people. Urban expansion has reached to suburban areas due to population growth and socio economic development, not to mention the rapid increase of transportation. Result of these changes causes a change of microclimate in urban areas. The most evident phenomenon is the increase of urban surface temperature as compared with suburban areas, "heat island" is formed in the atmospheric boundary above urban area. It could make serious environmental problems for its inhabitants (e.g., urban waterlogged and thermal pollution). Thermal infrared remote sensing bands, proved its capability in monitoring temperature field. The purpose of this study is to evaluate the use of Landsat TM, ETM+, OLI and TIRS data for indicating temperature differences in urban areas, in order to achieve a spatiotemporal study, using data between 1984 and 2014, and showing the relationship between urban expansion and the heat island effect during time, producing maps that shows the distribution of urban temperature. Results can be combined with land use/ land cover maps or thermal-land cover and operated as reference for urban planning and future solutions to reduce heat island effect.
THE PRESENT AND FUTURE STATE-OFTHE -

Ma Recently, treatment with 2 newer classes of type 2 diabetes drugs were found to reduce events in patients with diabetes and cardiovascular (CV) disease, a group common in cardiology clinics. The sodium-glucose cotransporter 2 inhibitor, empagliflozin, markedly and rapidly reduced CV death and heart failure hospitalization, likely with hemodynamic/ metabolic-driven mechanisms of action. More recently, the glucagon-like peptide–1 receptor agonists liraglutide and semaglutide also reduced CV death and/or major adverse CV events, but did so more slowly and did not influence heart failure risks, suggesting alternative mechanisms of benefit. We will discuss drug therapy for diabetes relative to CV risk, briefly summarize key findings of CV benefit from recent trials, discuss potential mechanisms for benefits of sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide–1 agonists, and suggest how such drugs might be embraced by CV specialists to reduce CV events and mortality in their patients. (J Am Coll Cardiol 2017;69:2646–56) © 2017 by the American College of Cardiology Foundation.
Charakterisierung des morphologischen Entwicklungspotenzials von der Oozyte bis zum Embryo

Ein entscheidender Faktor bezuglich des Ausgangs einer Kinderwunschtherapie ist die Auswahl und die Qualitat der zu transferierenden Embryonen. Die mikroskopische, morphologische Beurteilung steht dabei heutzutage im Mittelpunkt der Routine. Eine prospektive Multicenter-Studie mit 564 Zyklen und der morphologischen Charakterisierung von 4778 MII-Oozyten hatte zum Ziel, die relevanten Marker der Oozyte und spater der Vorkernstadien herauszuarbeiten und den Verlauf der Zellteilung und der daraus resultierenden Embryonen und Schwangerschaften zu dokumentieren. Die Multicenter-Studie konnte zeigen, dass einzelne extraoder intrazytoplasmatische Auffalligkeiten der Oozyte lediglich einen Einfluss auf die Befruchtungsrate, jedoch keinen signifikanten Einfluss auf die weitere Entwicklung haben. Die Anzahl an Anomalien charakterisiert aber sehr deutlich das Potenzial der Zelle. Das Vorkernscoring wurde in der Studie bezuglich der Symmetrie der Vorkerne und der Nukleoli in den Vorkernen (Z-Score) durchgefuhrt und konnte ebenfalls signifikante Vorteile aufzeigen. Die sich entwickelnden Embryonen wurden aufgrund der Morphologie der Oozyte und Vorkernstadien ausgewahlt. Die Multicenter-Studie konnte die hierarchische Bedeutung der einzelnen Scoringsysteme aufzeigen. Die Schwangerschaftsraten bei positiven Scores (Oozyte 37,3 %, Vorkernstadien 39,4 %, Embryonen 53,4 %) belegen, dass die Beobachtung des dynamischen Prozesses von der Oozyte bis zum Embryo (57,7 %) die besten Erfolgsaussichten hat. Diese Ergebnisse werden mit der Ubereinkunft des Istanbul Consensus Workshops (Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting) bezuglich der morphologischen Charakterisierung von der Oozyte bis zum Embryo verglichen.
Top‐down control as important as nutrient enrichment for eutrophication effects in North Atlantic coastal ecosystems

Seagrass and seaweed habitats constitute hotspots for diversity and ecosystem services in coastal ecosystems. These habitats are subject to anthropogenic pressures, of which eutrophication is one major stressor. Eutrophication favours fast-growing ephemeral algae over perennial macroalgae and seagrasses, causing habitat degradation. However, changes in top-down control, caused by, for example, overfishing, may also have negative impacts on such habitats by decreasing grazer control of ephemeral algae. Meanwhile, systematic analyses estimating top-down effects of predator manipulations across a wide range of studies are missing, limiting the potential use of top-down control measures in coastal management. Here, we review the literature on experiments that test top-down and bottom-up controls in seagrass Zostera marina and seaweed Fucus spp. food webs in the North Atlantic. Using meta-analysis and meta-regression, we compare effect sizes of consumer and nutrient manipulations on primary producers, grazers and mesopredators. Presence of mesopredators on average doubled the biomass of ephemeral algae through trophic cascades, mainly mediated via negative effects on amphipods and isopods. Of the grazers, gastropods had twice as strong a negative effect on ephemeral algae as amphipods/isopods, but responded weakly to both predators and fertilization. In accordance with theory, top-down effects became stronger with eutrophication. Across studies, top-down effects on ephemeral algae at all trophic levels are on par with eutrophication effects. However, the few studies manipulating piscivorous fish make estimates of their top-down effects uncertain.Synthesis and applications. Consistently strong top-down effects in coastal ecosystems call for an integrated ecosystem perspective. Management should consider measures to improve stocks of predatory fish and reduce mesopredators for restoration and conservation of essential seagrass and seaweed habitats, thereby increasing the long-term viability of ecosystem services from coastal habitats.Editor's Choice
A note on auctions with compulsory partnership

We study a symmetric, profitt share, common value auction with a twist: One (fixed) Bidder, if not winning the auction, has to enter a partnership with the winner, sharing both expenses and revenue at rate (say) 0 < r < 1. We show that it doesn't have an equilibrium in pure strategies.
Posttraumatic Stress Disorder The Role of Rumination in Elevating Perceived Stress in-May 22

Rumination has been shown to be important in both the maintenance and severity of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). Increased rumination has also been linked to perceptions of increased stress, which in turn are significantly associated with increased PTSD severity. The present study sought to examine this relationship in more detail by means of a mediation analysis. Forty-nine female survivors of interpersonal violence who met Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.; DSM-IV-TR) criteria for PTSD were administered the Clinician-Administered PTSD Scale (CAPS), the Ruminative Thought Style Questionnaire (RTS), the Perceived Stress Scale (PSS), and the Beck Depression Inventory–II (BDI-II). Results indicated that perceived stress mediates the relationship between rumination and PTSD, but did not do so after controlling for depression. Such results provide further evidence for the overlap between PTSD and MDD, and, in broader clinical practice, translate to a sharper focus on rumination and perceived stress as maintenance factors in both disorders. 1University of Missouri–St. Louis, USA 2Washington University in St. Louis, MO, USA Corresponding Author: Emily Hu, Center for Trauma Recovery, University of Missouri–St. Louis, 8001 Natural Bridge Road, Saint Louis, MO 63121, USA. Email: yeh423@umsl.edu 511697 JIVXXX10.1177/0886260513511697Journal of Interpersonal ViolenceHu et al. research-article2013 at THAMMASAT UNIVERSITY on October 7, 2014 jiv.sagepub. com Downloaded from 2 Journal of Interpersonal Violence XX(X)
Preclinical Combinatorial Approach to Enhance Radiotherapy Effects and Reduce its Morbidity May Be Tested in the Clinic Reading the Platinum Priority

Reading the Platinum Priority Editorial by Cozzarini [1] on the possibility that ‘‘whole-pelvis radiotherapy (RT) in the setting of radical radiation treatment of clinically localized prostate carcinoma’’ may improve clinical outcomes at the plausible cost of higher morbidity (hematologic issues are mainly highlighted by Cozzarini), I would like to highlight the results of several recent preclinical studies searching for a better effect of RT by (1) increasing the effects of RT with new radiosensitizers that will allow a reduction in RT dose while preserving its benefits and (b) improving the post-RT effect by extending the anticancer activity. Although these observations are ‘‘off target’’ concerning the goals of the editorial, they may be valuable in planning future research to test their feasibility and true benefits. A clinical formulation of hybrid manganese dioxide nanoparticles (MDNPs) using biocompatible materials to re-oxygenate the tumor microenvironment (TME) via reaction with endogenous H2O2 has been proposed as an adjuvant in treating tumors with RT [2]. In a murine model, approximately 40% of tumor-bearing mice were tumor-free after a single treatment with MDNPs + RT at a 2.5-fold lower dose than required to achieve the same curative treatment without MDNPs. Nevertheless, the authors stated ‘‘Ideally 100% curative treatment is desirable . including the combination therapy of MDNPs and RT studied here. However, there always are poor-responding individuals in clinic and preclinical studies due to a variety of factors . we believe that heterogeneity in tumors . plays a role in the nonuniform response to the treatment’’. Hypoxia in the TME causes resistance to RT and contributes to poor prognosis in patients by increasing HIF-1 [2]. Moreover, inhibition of HIF-1 during the post-RT
eview rentuximab vedotin in relapsed / refractory Hodgkin lymphoma : An pdated review of published data from the named patient program

Brentuximab vedotin was available via named patient program (NPP) to patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) or systemic anaplastic large-cell lymphoma in ∼60 non-US/Canadian countries, before local approval. Published results were examined recently; through systematic literature review, we identified 12 new NPP publications. Most (10/12) publications included new NPP data describing 8 unique cohorts (N = 480; all R/R HL) and new participating countries. Overall response rates were 58–80%, and complete remission rates were 10–40%. With median follow-up of 9.5–26 months, median rentuximab vedotin D30 odgkin lymphoma amed patient program progression-free survival was 5–10.5 months and median overall survival (OS) had not been reached in most cohorts; 1and 2-year OS was 67–76% and 58–67%, respectively. Tolerability was as expected from previous reports. Despite intrinsic bias and heterogeneous cohorts, this update supports previous findings showing comparable efficacy and tolerability of brentuximab vedotin between real-world practice and phase 2 trial results in R/R HL. © 2016 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC ∗ Corresponding author at: Institute of Hematology and Medical Oncology, ‘L. & . Seràgnoli, Policlinico Sant’Orsola-Malpighi, University of Bologna, via Massarenti , 40138 Bologna, Italy. E-mail address: pierluigi.zinzani@unibo.it (P.L. Zinzani). 1 A wholly owned subsidiary of Takeda Pharmaceutical Company Ltd. ttp://dx.doi. org/10.1016/j.critrevonc. 2016.04.019 040-8428/© 2016 The Authors. Published by Elsevier Ireland Ltd. This is an open access c-nd/4.0/). BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Satoumi Ecosystems and a New Commons: Ecological and Institutional Linkages between Human and Nature

“Satoumi” is defined simply as a seascape with “high productivity and biodiversity in the coastal sea area with human interaction” (Yanagi, 2006). Unlike the satoyama, in which human interaction with nature can be recognized as a visible landscape, the satoumi seems to be an invisible seascape and uncertain without close observation. To demonstrate the concept and practices prevailing in the satoumi more concretely, ecological and institutional effectiveness is examined in small-scale fisheries in western Japan. The focus is access rights in historical continuation between pre-modern and modern periods leading to contemporary fisheries jurisdictions. Stationary fisheries such as bamboo weir, tidal stone weir, and set net fisheries found in Okinawa and the Seto Inland Sea are chosen to demonstrate biologically and institutionally positive effects on the satoumi. In stationary fisheries, conservation and productivity are generally positively realized through communal efforts to maintain the installations. Yet, in individualistic set net fisheries, efforts to conserve marine resources should be more elaborately promoted to avoid over-fishing. In debates on conservation of MPAs (marine protected areas), governance to mitigate serious contradiction among stakeholders is a primary concern. Yet, as it is often hard to reach a final decision in launching MPAs, a new concept of the commons is highly recommended to provide an effective framework for conserving biodiversity as well as promoting marine production.
Secondary mechanisms associated with TBI

Traumatic brain injury (TBI), a major global health and socioeconomic problem, is now established as a chronic disease process with a broad spectrum of pathophysiological symptoms followed by long-term disabilities. It triggers multiple and multidirectional biochemical events that lead to neurodegeneration and cognitive impairment. Recent studies have presented strong evidence that patients with TBI history have a tendency to develop proteinopathy, which is the pathophysiological feature of neurodegenerative disorders such as Alzheimer disease (AD), chronic traumatic encephalopathy (CTE), and amyotrophic lateral sclerosis (ALS). This review mainly focuses on mechanisms related to AD, CTE, and ALS that are induced after TBI and their relevance to the advancement of these neurodegenerative diseases. This review encompasses acute effects and chronic neurodegenerative consequences after TBI for a better understanding of TBI-induced neuronal death and to design therapies that will effectively treat patients in the primary or secondary progressive stages.
Robust Stabilization and Control for Uncertain Neural Networks with Mixed Time Delays

This paper is concerned with the problem of robust stabilization and control for a class of uncertain neural networks. For the robust stabilization problem, sufficient conditions are derived based on the quadratic convex combination property together with Lyapunov stability theory. The feedback controller we design ensures the robust stability of uncertain neural networks with mixed time delays. We further design a robust controller which guarantees the robust stability of the uncertain neural networks with a given performance level. The delay-dependent criteria are derived in terms of LMI (linear matrix inequality). Finally, numerical examples are provided to show the effectiveness of the obtained results.
Active Status Update Packet Drop Control in an Energy Harvesting Node

This paper considers an energy harvesting sensor node with battery size Bmax that recharges its battery through an incremental energy harvesting process and receives updates from a single information source in slotted time. The node actively decides to power down (OFF) or up (ON) the communication circuitry for a portion of its operation time in order to maintain energy efficiency. Update packets arriving in ON (OFF) periods are received (discarded). A deterministic energy cost per time is paid during ON periods. The power down decision can be in partial or full nature, yielding various options for deciding ONOFF intervals. We develop age-threshold based power ON-OFF schemes to minimize age of information at the node subject to energy harvesting constraints with partial and full power down options for Bmax = 1 and Bmax = TO cases.
DISCOVERY OF PHOTON INDEX SATURATION IN THE BLACK HOLE BINARY GRS 1915+105

We present a study of the correlations between spectral, timing properties, and mass accretion rate observed in X-rays from the Galactic black hole (BH) binary GRS 1915+105 during the transition between hard and soft states. We analyze all transition episodes from this source observed with the Rossi X-ray Timing Explorer, coordinated with Ryle Radio Telescope observations. We show that broadband energy spectra of GRS 1915+105 during all these spectral states can be adequately presented by two bulk motion Comptonization (BMC) components: a hard component (BMC1, photon index Γ1 = 1.7–3.0) with turnover at high energies and soft thermal component (BMC2, Γ2 = 2.7–4.2) with characteristic color temperature ⩽1 keV, and the redskewed iron-line (LAOR) component. We also present observable correlations between the index and the normalization of the disk “seed” component. The use of “seed” disk normalization, which is presumably proportional to mass accretion rate in the disk, is crucial to establish the index saturation effect during the transition to the soft state. We discovered the photon index saturation of the soft and hard spectral components at values of ≲4.2 and 3, respectively. We present a physical model which explains the index–seed photon normalization correlations. We argue that the index saturation effect of the hard component (BMC1) is due to the soft photon Comptonization in the converging inflow close to the BH and that of soft component is due to matter accumulation in the transition layer when mass accretion rate increases. Furthermore, we demonstrate a strong correlation between equivalent width of the iron line and radio flux in GRS 1915+105. In addition to our spectral model components we also find a strong feature of “blackbody (BB)-like” bump whose color temperature is about 4.5 keV in eight observations of the intermediate and soft states. We discuss a possible origin of this “BB-like” emission.