Miracle-dz/UniFAR-FTUs huggingface dataset:
Fat storage‐inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes, and regulates triglyceride accumulation and insulin sensitivity in adipocytes

Fat storage–inducing transmembrane protein 2 (FIT2) aids in partitioning of cellular triacylglycerol into lipid droplets. A genome‐wide association study reported FITM2‐R3H domain containing like‐HNF4A locus to be associated with type 2 diabetes (T2DM) in East Asian populations. Mice with adipose tissue (AT)‐specific FIT2 knockout exhibited lipodystrophic features, with reduced AT mass, insulin resistance, and greater inflammation in AT when fed a high‐fat diet. The role of FIT2 in regulating human adipocyte function is not known. Here, we found FIT2 protein abundance is lower in subcutaneous and omental AT obtained from patients with T2DM compared with nondiabetic control subjects. Partial loss of FIT2 protein in primary human adipocytes attenuated their lipid storage capacity and induced insulin resistance. After palmitate treatment, triacylglycerol accumulation, insulininduced Akt (Ser‐473) phosphorylation, and insulin‐stimulated glucose uptake were significantly reduced in FIT2 knockdown adipocytes compared with control cells. Gene expression of proinflammatory cytokines IL‐18 and IL‐6 and phosphorylation of the endoplasmic reticulum stress marker inositol‐requiring enzyme la were greater in FIT2 knockdown adipocytes than in control cells. Our results show for the first time that FIT2 is associated with T2DM in humans and plays an integral role in maintaining metabolically healthy AT function. —Agrawal, M. , Yeo, C. R. , Shabbir, A. , Chhay, V. , Silver, D. L. , Magkos, F. , Vidal‐Puig, A. , Toh, S. ‐A. Fat storage‐inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes, and regulates triglyceride accumulation and insulin sensitivity in adipocytes. FASEB J. 33, 430–440 (2019). www.fasebj. org
In Vitro Cytotoxicity and Morphological Assessments of GO-ZnO against the MCF-7 Cells: Determination of Singlet Oxygen by Chemical Trapping

Graphene-based materials have attracted considerable interest owing to their distinctive characteristics, such as their biocompatibility in terms of both their physical and intrinsic chemical properties. The use of nanomaterials with graphene as a biocompatible agent has increased due to an uptick in dedication from biomedical investigators. Here, GO-ZnO was characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), ultraviolet-visible (UV-Vis) spectroscopy, energy dispersive X-ray analysis (EDAX), and Raman spectroscopy for structural, morphological, and elemental analysis. The toxic extent of GO-ZnO was noted by a methyl-thiazole-tetrazolium (MTT), while cellular morphology was observed towards the MCF-7 cells using an inverted microscope at magnification 40×. The cytotoxic effect of GO-ZnO investigated the cell viability reduction in a dose-dependent manner, as well as prompted the cell demise/destruction in an apoptotic way. Moreover, statistical analysis was performed on the experimental outcomes, with p-values < 0.05 kept as significant to elucidate the results. The generation of reactive oxygen species (ROS) demonstrated the potential applicability of graphene in tumor treatment. These key results attest to the efficacy of GO-ZnO nanocomposites as a substantial candidate for breast malignancy treatment.
Addressing smoking among people living with HIV: a cross-sectional survey of Australian HIV health practitioners’ practices and attitudes

ABSTRACT People living with HIV (PLHIV) have high rates of tobacco smoking, and smoking is a leading cause of premature mortality and morbidity. It is important to understand HIV healthcare providers’ practices and attitudes towards addressing smoking with their patients. An online survey that measured: (i) use of the 5A framework for addressing smoking (Ask, Assess, Advise, Assist, Arrange) and (ii) attitudes and barriers to addressing smoking cessation was distributed by relevant professional bodies. Eligible participants were Australian health practitioners providing healthcare to PLHIV. Of the 179 respondents, most reported practising at least one of the 5As: Ask (94%); Assess (78%); Advise (82%); Assist (89%); and Arrange (73%). Practising the full 5A framework (completing at least one activity from each A) was less common (62%) and associated with having undertaken smoking cessation training (OR 2.1, CI 1.1–3.9), being a medical practitioner (OR 6.0, CI 3.1–11.6), having greater perceived knowledge and resources (OR 1.7, CI 1.3–2.4) and more positive attitudes (OR 1.5, CI 1.1–2.0). Common barriers to delivering cessation assistance related to knowledge and availability of resources. Development and greater dissemination of effective smoking cessation training and resources may be required to ensure healthcare practitioners have the capacity to complete all aspects of the 5A framework for smoking cessation and support their patients with HIV who smoke.
Parikh Motivated Study on Repetitions in Words

We introduce the notion of general prints of a word, which is substantialized by certain canonical decompositions, to study repetition in words. These associated decompositions, when applied recursively on a word, result in what we term as core prints of the word. The length of the path to attain a core print of a general word is scrutinized. This paper also studies the class of square-free ternary words with respect to the Parikh matrix mapping, which is an extension of the classical Parikh mapping. It is shown that there are only finitely many matrix-equivalence classes of ternary words such that all words in each class are square-free. Finally, we employ square-free morphisms to generate infinitely many pairs of square-free ternary words that share the same Parikh matrix.
Failure Generates Impulsivity Only When Outcomes Cannot Be Controlled

Verbruggen, Chambers, Lawrence, and McLaren (2017) recently challenged the view that individuals act with greater caution following the experience of a negative outcome by showing that a gambled loss resulted in faster reaction time (RT) on the next trial. Over three experiments, we replicate and establish the boundary conditions of this effect in the context of a simple game (rock, paper, scissors [RPS]). Choice responding against unexploitable opponents replicated the link between failure and faster responding. However, individuals with high win-rates against exploitable opponents initiated slower rather than faster responding following loss. The data suggest that the link between failure and impulsivity is limited to contexts where participants cannot exert control over outcomes.
Moving Forward on the Journey: Spirituality and Family Resilience After Spinal Cord Injury

Purpose/Objective: The aim of this exploratory study was to consider how spirituality (encompassing meaning, hope and purpose), may facilitate family resilience after spinal cord injury (SCI) over time. Research Method/Design: A qualitative, longitudinal study design was adopted. Semistructured interviews were conducted with 10 family dyads (consisting of the individual with SCI and a nominated family member) on 2 occasions, 6 months apart. A thematic analysis was conducted. Results: Participants reported drawing upon a range of different sources of spirituality, including religious faith, the natural world, inner strength, and meaningful connectedness with others. These sources of spirituality were often tested in some way after the SCI. Meaning-making responses to these tests were linked with 3 key outcomes: gratitude, hope, and deeper connectedness with others, assisting families to move forward in their journey after SCI. Over time sources of spirituality did not change significantly; however, the intensity of spiritual experience lessened for some families. Conclusions: This study indicated that spirituality after SCI plays an important role for both the injured individual and their family members. Families draw upon a range of sources of spirituality, and these sources of spirituality may assist the family to move forward together after SCI. Further investigation of how health professionals can better address spirituality during spinal rehabilitation is warranted.
Benign Cell Boosters: Exploring Novel Cancer Therapies Through Simulation

2 Department of Computer Science, University of New Mexico, Albuquerque, NM, 87131. A quarter century ago, Nowell identified cancer as an evolutionary problem[1]. The cells in a tumor are evolving through mutation and natural selection. There is an emergent \ecology" in the body where tumor cells must compete for the limited resources of a tumor. Any mutant clone with a competitive advantage will tend to spread in a tumor. Unfortunately, this form of natural selection includes selection for resistance to therapies that are imposed on the tumor. Therefore, many of our therapies select for resistant cells and result in a relapse with a drug resistant tumor. In essence, evolution works against us in the case of cancer. Our experimental work traces this evolution in Barrett's esophagus through both genetic and epi-genetic alterations. We are able to track the evolution of mutant clones both in space, across the surface of the esophagus, and in time, over years.
The Molecular Interplay between Axon Degeneration and Regeneration

Neurons face a series of morphological and molecular changes following trauma and in the progression of neurodegenerative disease. In neurons capable of mounting a spontaneous regenerative response, including invertebrate neurons and mammalian neurons of the peripheral nervous system (PNS), axons regenerate from the proximal side of the injury and degenerate on the distal side. Studies of Wallerian degeneration slow (WldS/Ola) mice have revealed that a level of coordination between the processes of axon regeneration and degeneration occurs during successful repair. Here, we explore how shared cellular and molecular pathways that regulate both axon regeneration and degeneration coordinate the two distinct outcomes in the proximal and distal axon segments. © 2018 Wiley Periodicals, Inc. Develop Neurobiol 00: 000–000, 2018
Animacy effects in episodic memory: do imagery processes really play a role?

ABSTRACT Animates are remembered better than inanimates because the former are ultimately more important for fitness than the latter. What, however, are the proximate mechanisms underpinning this effect? We focused on imagery processes as one proximate explanation. We tested whether animacy effects are related to the vividness of mental images (Study 1), or to the dynamic/motoric nature of mental images corresponding to animate words (Study 2). The findings showed that: (1) Animates are not estimated to be more vivid than inanimates; (2) The potentially more dynamic nature of the representations of animates does not seem to be a factor making animates more memorable than inanimates. We compared (Study 3) a condition in which participants had to categorise animate and inanimate words with a condition in which they had to form mental images from them. The animacy effect was significant after categorising but not after forming mental imagery. In Study 4, we compared the recall rates of animates and inanimates after these words had been encoded with or without a concurrent visual-spatial memory load. Again, animates were better remembered than inanimates. Taken overall, the findings do not fit well with the hypothesis that imagery processes support animacy effects in memory.
Terahertz Image Detection with the Improved Faster Region-Based Convolutional Neural Network

In recent years, terahertz imaging systems and techniques have been developed and have gradually become a leading frontier field. With the advantages of low radiation and clothing-penetrable, terahertz imaging technology has been widely used for the detection of concealed weapons or other contraband carried on personnel at airports and other secure locations. This paper aims to detect these concealed items with deep learning method for its well detection performance and real-time detection speed. Based on the analysis of the characteristics of terahertz images, an effective detection system is proposed in this paper. First, a lots of terahertz images are collected and labeled as the standard data format. Secondly, this paper establishes the terahertz classification dataset and proposes a classification method based on transfer learning. Then considering the special distribution of terahertz image, an improved faster region-based convolutional neural network (Faster R-CNN) method based on threshold segmentation is proposed for detecting human body and other objects independently. Finally, experimental results demonstrate the effectiveness and efficiency of the proposed method for terahertz image detection.
Personality Disorder Traits: Testing Insight Regarding Presence of Traits, Impairment, and Desire for Change

Mixed findings exist as to whether personality pathology involves a critical lack of awareness and insight. Research questions about insight and awareness in personality pathology are typically assessed via comparing self- and informant reports of traits. However, recent studies have measured insight by asking individuals to evaluate additional questions about impairment and desire to change. The present study uses a variety of approaches to examine these issues, including investigations of convergence between self- and informant reports (N = 197 dyads; correlations and comparisons of means) of personality psychopathology, desired trait levels, and perceptions of impairment. Convergence was observed between levels of self- and informant-reported traits, desired traits, and impairment. However, individuals rated themselves higher on pathological trait levels and impairment than did their informants. Furthermore, individuals with relatively higher pathological traits desired higher levels of these traits (but lower than their actual scores) than individuals with lower scores; on the actual measurement scale, however, these higher scorers rated their desired level below the neutral point. Overall, individuals with pathological personality traits possess a reasonable degree of insight into their actual trait levels and associated impairment.
Staged treatment and acceptability guidelines in early psychosis study (STAGES): A randomized placebo controlled trial of intensive psychosocial treatment plus or minus antipsychotic medication for first‐episode psychosis with low‐risk of self‐harm or aggression. Study protocol and baseline characte

It is now necessary to investigate whether recovery in psychosis is possible without the use of antipsychotic medication. This study will determine (1) whether a first‐episode psychosis (FEP) group receiving intensive psychosocial interventions alone can achieve symptomatic remission and functional recovery; (2) whether prolonging the duration of untreated psychosis (DUP) in a sub‐group according to randomisation will be associated with a poorer outcome and thereby establish whether the relationship between DUP and outcome is causative; and (3) whether neurobiological changes observed in FEP are associated with the psychotic disorder or antipsychotic medication. Baseline characteristics of participants will be presented.
Computational methods for analyzing and modeling genome structure and organization

Recent advances in chromosome conformation capture technologies have led to the discovery of previously unappreciated structural features of chromatin. Computational analysis has been critical in detecting these features and thereby helping to uncover the building blocks of genome architecture. Algorithms are being developed to integrate these architectural features to construct better three‐dimensional (3D) models of the genome. These computational methods have revealed the importance of 3D genome organization to essential biological processes. In this article, we review the state of the art in analytic and modeling techniques with a focus on their application to answering various biological questions related to chromatin structure. We summarize the limitations of these computational techniques and suggest future directions, including the importance of incorporating multiple sources of experimental data in building a more comprehensive model of the genome.
Adjuvant treatment with Yupingfeng formula for primary nephrotic syndrome in children

Background: Yupingfeng formula (YPFF) has been prescribed as adjuvant treatment for pediatric patients with primary nephrotic syndrome (PNS) in China for years. However, the efficacy and adverse effects of these formulations are controversial. A systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to evaluate the benefits and harms of YPFF in treating PNS in children. Methods: The MEDLINE, EMBASE, Cochrane Library, CNKI, VIP, WanFang, and CBM databases were searched for RCTs comparing therapies with and without YPFF for PNS from inception to May 13, 2017. Relative risk (RR) and 95% confidence intervals (CI) were expressed for dichotomous outcomes, and weighted mean difference (WMD) with 95% CI for continuous outcomes. Cochrane collaboration tool was used to evaluate the risk of bias of methodologies. Results: Eight studies with 538 participants were identified. Treatment with YPFF significantly increased serum levels of IgA (WMD, 0.48, 95% CI, 0.40–0.56, P < .001), IgG (WMD, 3.36, 95% CI, 2.61–4.12, P < .001), CD4+ T-lymphocytes (WMD, 3.35, 95% CI, 2.26–4.43, P < .001), but decreased the level of CD8+ T-lymphocytes (WMD, –3.38, 95% CI –5.48 to –1.28, P = .002). YPFF also increased the rates of complete remission (RR: 1.35, 95% CI, 1.09–1.67, P = .005), and decreased the rates of relapse (RR: 0.57, 95% CI, 0.45–0.71, P < .001), and infection (RR: 0.72, 95% CI 0.62–0.83, P < .001). There was no significant difference in the level of IgM between the groups (WMD, 0.12, 95% CI –0.11–0.35, P = .322). Conclusions: YPFF could improve total remission rate and decrease the frequency of relapse and infection rate. The beneficial influence of YPFF may be associated with its immunomodulatory effects. More high-quality studies with larger sample sizes are needed to further identify its efficacy and safety.
Effect of genetic drift on determinants of protein evolution

A number of previous studies reported that gene expression, tissue specificity, gene essentiality and the number of protein–protein interactions influence the rate of protein evolution. Here we investigated the influence of effective population size (Ne) on these determinants of protein evolution. For this purpose, we compared the ratio of non-synonymous-to-synonymous diversities (πN/πS) estimated for protein-coding genes of Mus musculus castaneus and Mus musculus musculus: populations with high and low Ne respectively. Our results revealed that the difference between πN/πS estimated for genes with high and low expression levels was significantly smaller for M. m. musculus compared to that observed for M. m. castaneus. The difference between the πN/πS of broadly expressed and tissue specific genes was much higher for M. m. castaneus compared to that of M. m. musculus. Furthermore, the difference between the πN/πS computed for essential and non-essential genes was much smaller for M. m. musculus than M. m. castaneus. A similar pattern was observed for genes involved in many protein–protein interactions versus those involved in one. These results suggest that the effects of the determinants on protein evolution were much reduced for the population with small Ne due to increased genetic drift.
Cerebral catheter angiography and its complications

Catheter-based angiography is an important but invasive procedure in vascular neurology. It is used mainly for diagnosis and for planning treatment in patients with a suspected underlying vascular abnormality. It is often performed as a semiurgent, planned investigation or linked to an interventional procedure. Cerebral angiography provides high-resolution, three-dimensional, pathoanatomical data about the cerebral vasculature and also allows real-time analysis of blood flow. Contrast injections can be repeated to identify subtleties. A physical intervention may also follow angiography. For these reasons, angiography remains the gold standard for delineating vascular lesions of the brain (and spine). Permanent neurological complications are rare, approximately 1%, but become increasingly common in patients aged over 55 years. The main complications are embolic stroke, groin haematoma and contrast-induced nephropathy. In the new era of thrombectomy, it may transpire that other specialists including neurologists may learn to perform the procedure and to manage its complications.
Biochemical and Muscle Mechanical Postmarathon Changes in Hot and Humid Conditions.

Gutiérrez-Vargas, R, Martín-Rodríguez, S, Sánchez-Ureña, B, Rodríguez-Montero, A, Salas-Cabrera, J, Gutiérrez-Vargas, JC, Simunic, B, and Rojas-Valverde, D. Biochemical and muscle mechanical postmarathon changes in hot and humid conditions. J Strength Cond Res XX(X): 000-000, 2018-The aim of this study was to compare biochemical changes and mechanical changes in the lower-limb muscles before and after a marathon race in hot and humid conditions. Eighteen healthy runners participated in a marathon at between 28 and 34° C and 81% humidity in Costa Rica. Serum magnesium (Mg), creatine phosphokinase (CPK), lactate dehydrogenase, and hematocrit (HCT) were measured before and after the marathon. Tensiomyography measurements from the rectus femoris (RF) and vastus medialis, muscle displacement (Dm), contraction time (Tc), and velocities of contraction to 10 and 90% of Dm (V10 and V90) were obtained before and after the marathon. Postrace measurements showed a 544% increase in CPK (t(17): -6.925, p < 0.01), a 16% increase in HCT (t(17): -7.466, p < 0.01), a 29% decrease in Mg (t(17): 3.91, p = 0.001), a 2% decrease in body mass (t(17): 4.162, p = 0.001), a 4% increase in Tc of the RF (t(17): -2.588, p = 0.019), and a 12% increase in Dm of the RF (t(17): -2.131, p < 0.048) compared with prerace measurements. No significant biochemical or mechanical differences were found between runners in terms of their finish times. These findings showed that completing a marathon in hot and humid conditions induced a significant reduction in lower-limb muscle stiffness, body mass, and Mg, and increased neuromuscular fatigue, CPK, and HCT, because of muscle damage and dehydration. Knowledge of the effects of heat and humidity may be of value for coaches and sports medicine practitioners in developing effective hydration and recovery protocols for marathon runners in these special conditions.