Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of digital technologies in the innovation process

Innovation scholars and practitioners are discussing at length on the use of digital technologies in the innovation process of companies. Most of them have paid special attention on the use of digital technologies to deploy or evolve systems for managing the life cycle of products or services, accelerate their realization, and pursuing them to reach global markets in record times. Although the use of digital technologies is a widely discussed topic in literature, nowadays it seems to be even more relevant in the fields of management and innovation due to the important changes characterizing companies and their innovation activity. Indeed, companies are increasingly relying on knowledge and technology developed outside their borders, as well as transferring ideas to external partners, selling intellectual property, technology and licensing fees. In this case, the amount of knowledge and technology exchanged within and outside the boundaries of the firm increases significantly, that requires the use and implementation of new technologies. Accordingly, companies can use and
University of Dundee Chitin-Binding Protein of Verticillium nonalfalfae Disguises Fungus from Plant Chitinases and Suppresses Chitin-Triggered Host Immunity

Citation for published version (APA): Volk, H. , Marton, K. , Flajsman, M. , Radisek, S. , Tian, H. , Hein, I. , Podlipnik, . , Thomma, B. P. H. J., Kosmelj, K. , Javornik, B. , & Berne, S. (2019). Chitin-Binding Protein of Verticillium nonalfalfae Disguises Fungus from Plant Chitinases and Suppresses Chitin-Triggered Host Immunity. Molecular Plant-Microbe Interactions, 32(10), 13781390. https://doi.org/10.1094/MPMI-03-19-0079-R
The Oligodendrocyte Cytoskeleton: A Major Player in Remyelination

How to cite this article Fressinaud C. The Oligodendrocyte Cytoskeleton: A Major Player in Remyelination. SM J Neurol Disord Stroke. 2018; 4(1): 1016s2. OPEN ACCESS Comparative anatomy shows that one of the main morphological differences between brains in line with the evolution of mammal species is the volume of white matter which increases proportionally more than other parameters (e.g. grey matter volume) between mice and humans for example [1]. Myelination of Central Nervous System (CNS) axons by Oligodendrocytes (OL) is essential to brain development and is required for the acquisition of complex skills [2]. Extraordinary metabolic machinery is necessary for this process since OL myelinate upto 20-60 axons with sheaths of 20-200 μm length and up to 100 membrane turns. The estimated surface of myelin synthesized per OL represents up to 5 50 000 μm2 a unique feature among cells [3]. This also implies an extreme development of their cytoskeleton to extend their processes to distant axons and supply molecules to forming myelin sheaths. In addition, OL have a peculiar structure and their cytoskeleton is enriched in microtubules though devoid of intermediate filaments, contrary to neurons (neurofilaments) and astrocytes (gliofilaments) [4].
Characterisation of Pseudosuccinea columella and Radix natalensis (Gastropoda: Lymnaeidae) in Egypt using shell and molecular data

ABSTRACT Pseudosuccinea columella and Radix natalensis live in the same habitat in Egypt and are important intermediate hosts of Fasciola hepatica and F. gigantica. Our study aimed to characterise both snail species using molecular analysis and shell measurements. The ranges of morphometric parameters overlapped in the two lymnaeids, indicating that they do not clearly differentiate the two species. PCR-sequence analysis of the nuclear ribosomal small subunit rRNA and the polymorphic mitochondrial cytochrome oxidase subunit 1 (CO1) genes were used to determine the genetic identity and the potential diversity of the snails. Little intrasequence variations were detected in the sequences of both gene loci, indicating the potential homogeneity of lymnaeid populations in Egypt. Generated sequences of the mitochondrial CO1 gene locus for R. natalensis showed obvious heterogeneity compared to other sequences in GenBank. Molecular characterisation of these lymnaeids might help to understand the snails’ biodiversity in a bid to control these populations and their related diseases.
Barents Sea megabenthos: Spatial and temporal distribution and production

This long-term observation of the faunal composition within the Barents Sea provides a benchmark for monitoring community changes caused by oceanographic variability, fishery activities, and crab predators (Chionoecetes opilio, Paralithodes camtschaticus), whose populations have been rapidly growing and spreading in recent years. In the Arctic systems, megabenthic communities comprise a significant part of benthic biomass and play an important role in carbon cycling on continental shelves. The gradual accumulation of knowledge on megabenthos may make it possible to assess their role in the ecosystem and ultimately contribute to a more rational management of the Barents Sea resources. This article represents an important series of long-term megabenthic observations in the Barents Sea. The main goal of our research is to identify spatial patterns and temporal trends in the megabenthic part of communities, including changes in the biomass and production values. As a part of the joint Norwegian-Russian ecosystem surveys, benthic experts have been identifying the invertebrates (megafauna) collected by bottom trawls during annual assessments of commercial stocks, such as Atlantic cod (Gadus morhua) and northern shrimp (Pandalus borealis). The sampling equipment used was a Campelen 1800 bottom trawl, rigged with rockhopper ground gear and towed on double warps, and standardized to a fixed sampling effort (equivalent to a towing distance of 0.75 nautical miles (nm), or 1.4 km). The processing of the biological material was conducted in accordance with standardized procedures, following the retrieval of each trawl. This work represents data from 5016 stations from 2005 to 2017, with a total sampled biomass of 238.4 tons and 14.9 million individual organisms. In total, 694 megabenthic species (1058 taxa) have been recorded, with the greatest diversity observed in the depth range of 100–400 m, while the largest mean catches were taken between depths of 600–800 m. The biomass (B) and production (P) values of the benthic megafauna were approximately stable during the 9 years of investigation, although there was a decreasing trend after 2014. The annual production P/B ratio of megabenthos was calculated to be at 0.3. The distribution, contribution to production, and gross biomass values of the megabenthos had been underestimated in the previous studies of zoobenthos. The results from this research show that, in the current warm period, the majority of the Barents Sea is in an intermediate state between the Arctic and boreal regions due to the wide distribution of boreal species toward the north. The dynamics of the mean biogeographical index (the border between areas of the dominance of boreal and Arctic species) within the central-southern part of the Barents Sea suggests that a large part of the area can be characterized as predominantly boreal intermediate since 2013.
Variation in daily energy expenditure in nesting Northern Wheatears (Oenanthe Oenanthe)

AI•STRACT. --The field metabolic rate (FMR) of 19 adult Northern Wheatears (Oenanthe oenanthe) feeding nestlings was measured with the doubly labeled water D2•80 technique (DLW) over three seasons. The energy expenditures of four almost fully grown nestlings were also measured with DLW (average consumption = 52 kJ/day). Adult wheatears expended on average 87.4 kJ/day, with no difference between females and males. This was 2.2 times the basal metabolic rate (BMR). Energy expenditure was 10% below that predicted for their body size. Parents collect three times as much energy to supply an average-sized brood of nearly grown nestlings than they need for self-maintenance. I found no difference in metabolic rate or metabolic intensity (multiples of BMR) between females brooding and feeding ectothermic chicks of 1-4 days of age and females that fed endothermic nestlings of 9-13 days of age. Brooding females had lower feeding rates and spent less time flying, so the similarity in FMR should be due to the energetic costs of brooding itself. Feeding rates correlated positively with FMR for late nestling females; proportion of active time spent in flight had no apparent effect. Brood size was unrelated to energy expenditure of females that fed large nestlings. I detected no effect of brood manipulations. Female condition (body mass divided by tarsus) varied positively with brood size. Females that cared for large broods had energy expenditures equal to those feeding small broods, but were apparently in better physical condition. Received 25 January 1988, accepted 16 July 1988.
Closing the STEM Labor Gap through a Path to Graduation for Low Income, Rural Students

Dr. Paul D. Adams is a native of Baton Rouge, Louisiana. He earned a B.S. in biochemistry from Louisiana State University, and a Ph.D. in biophysical chemistry from Case Western Reserve University. Currently, Adams is an Associate Professor of Chemistry and Biochemistry, as well as Cellular and Molecular Biology at the University of Arkansas, Fayetteville (UAF). At UAF, Adams studies the biochemistry and biophysics of proteins that play roles in the onset of cancer, and his research has garnered more than $3,000,000 in funding from the National Institutes of Health (NIH), the National Science Foundation (NSF), the Arkansas Biosciences Institute (ABI), the Arkansas Science and Technology Authority (ASTA), and the Winthrop P. Rockefeller Cancer Institute since 2007.
Symmetries of Collective Models in Intrinsic Frame

In the paper a very general definition of intrinsic frame, by means of group theoretical methods, is introduced. It allows to analyze nuclear properties which are invariant in respect to the group which defines the intrinsic frame. For example, nuclear shape is a well determined feature in the intrinsic frame defined by the Euclidean group. It is shown that using of intrinsic frame gives an opportunity to consider intrinsic nuclear symmetries which are independent of symmetries observed in the laboratory frame. An importance of the notion of partial symmetries is emphasized.
Fimbrial Adhesins of Escherichia coli

Fimbriae are long, threadlike protein polymers found on the surface of many strains of Escherichia coli. The presence of fimbriae has been found to be significantly correlated with pathogenicity, and specific fimbriae confer on pathogenic strains the ability to adhere to and colonize various specific host epithelia. A surprising variety of fimbrial adhesions have been found in E. coli; several unrelated groups of such proteins have been extensively characterized. Fimbriae of E. coli are strongly immunogenic. Their continuous interaction with host defenses has imposed heavy selective pressure on them, leading to a fine balance between functional necessity and maximal immunologic diversity. These important virulence factors may be exploited in various ways in the production of vaccination agents. Vaccines based on E. coli fimbriae have proved extremely successful in the veterinary sector, and several types of immunization are currently being tested in humans.
Assessment of psychosocial and demographic characteristics related to relapse in schizophrenic patients in psychiatric hospital of Assiut university.

Relapse among schizophrenic patients is a major challenge for mental health service providers in Egypt. Relapse has negative consequences and it can affect to patients, their families, the mental health care providers and the country's economy. The study aimed toassess psychosocial and demographic characteristics associated with relapse in schizophrenic patients. Subjects and Method: Adescriptive correlational research design was used in this study. purposive sample were utilized , consisting of 100 patients who have schizophrenia and accepted to share in the study. Tools of the study inculde personal data, socio economic assessment scale and a specially designed semi-structured scale of relapse factors. Results: The participants consisted of 100 patients (58 males, 42 females), high statistically significant relation was found between socio economic level and age group "(p= 0.007), no statistically significant relation was noticed between relapse factors and socio economic level. There is a negative correlation between social stigma and gender. The study concluded that there was a highly statistically significant relation between socio economic level and age group "(p= 0.007). ,However there wasn't statistically significant relation between relapse factors and socio economic level, negative correlation between social stigma and gender Recommendation, Primary mental health care must be enhanced to prevent relapse among mentally ill patients, further studies are needed to investigate these factors on larger sample size with another tools and different settings
Suppression of the neoplastic phenotype of aflatoxin B1-induced rat hepatoma cells by the retinoblastoma tumor suppressor gene

The retinoblastoma tumor suppressor gene product, RB protein, is a negative regulator of cell growth and antagonizes c-Myc oncoprotein. We have previously reported that the c-myc gene expression is aberrantly elevated in rat hepatocellular carcinomas induced by aflatoxin B1 (AFB1). In this paper, to elucidate the significance of the overexpression of c-myc gene in AFB, hepatocarcinogenesis, we analyzed the effects of a human RB cDNA expression vector, pSV2• RB, on the growth and tumorigenicity of Kagura-2 (K2) cells, which have been established from AFB1-induced rat hepatoma and overexpressing c-myc gene just as an original tumor. Even though any effects of exogeneous expression of RB gene on the transcriptional levels of c-myc and glutathione-S-transf erase P (GST-P) genes were not detected, pSV2 • RB-transf ected K2 cells significantly reduced the ability to form colonies in semi-solid medium, and their growth rate was markedly decreased in a lower concentration of serum. Moreover, tumors that formed by the transfectants in nude mice were much smaller, but were histologically indistinguishable from those of parental K2 cells. These results indicate that the enforced expression of RB gene suppresses the growth of K2 cells in vitro and in vivo without any effects on the expression level of c-myc mRNA.
Efficacy and safety of high-dose ultrasound cyclo-plasty procedure in refractory glaucoma.

AIM To evaluate the efficacy and safety of high-dose ultrasound cyclo-plasty (UCP) for the treatment of refractory glaucoma in Chinese patients. METHODS In this 6-month retrospective study, 37 eyes of 37 patients suffering from severe glaucoma with uncontrolled intraocular pressure (IOP) of ≥21 mm Hg underwent 8-s ultrasonic cyclocoagulation with ten active piezoelectric elements. A complete ophthalmic examination was performed before and at 1d, 1, 3, 6mo after UCP. Therapeutic success was defined as IOP reduction from baseline ≥20% and IOP ≥5 mm Hg without adding new glaucoma medication compare to baseline at the 6-month follow-up visit. In addition to mean IOP at each follow-up visit, medications used and complications were also detected and compared to baseline. RESULTS After UCP procedure, the mean IOP was significantly reduced (P<0.01) from the preoperative 44.1±11.9 mm Hg to postoperative 26.7±11.8 mm Hg at 3mo, and 30.4±14.5 mm Hg at 6mo. The overall mean IOP reductions achieved at 3 and 6mo were 39% and 31% compared to baseline IOP. Sixty-one percent of patients responded well to UCP treatment with a mean IOP reduction of 48% at 3mo and 42% at 6mo. Ocular pain in most of patients were alleviated. No serious intraoperative or postoperative complications occurred. CONCLUSION High-dose UCP treatment is an effective and safe procedure to reduce IOP in Chinese patients with severe glaucoma.
Smart Grid communication applications: measurement equipment and networks architecture for data and energy flow

Smart Grid is an advanced two way data and energy flow capable of self-healing, adaptive, resilient, and sustainable with prediction capability of possible fault. This article aimed to disclose Smart Grid communication in a logical way to facilitate the understanding of each component function. The study was focused on the improvement, advantages, common used design, and possible feature of Smart Grid communication components. The results of the study divide the Smart Grid communication application into two main category i.e. measurement equipment and network architecture. Measurement equipment consists of Advance Metering Infrastructure, Phasor Measurement Unit, Intelligent Electronic Devices, and Wide Area Measurement System. The network architecture is divided based on three hierarchies; local area network for 1 to 100 m with 100 kbps data rate, neighbour area network for 100 m to 10 km with 100 Mbps data rate, and wide area network for up to 100 km with 1 Gbps data rate. More information is provided regarding the routing protocol for each network from various available protocols. The final section presents the energy and data flow architecture for Smart Grid implementation based on the measurement equipment and the network suitability. This article is expected to provide a comprehensive guide and comparison surrounding the technologies supporting Smart Grid implementation especially on communication applications.
Policy Coordination for National Climate Change Adaptation in Europe: All Process, but Little Power

Climate change adaptation (CCA) is argued to require coordinated policy responses because it is a complex, long-term, knowledge intensive, cross-sectoral, and multi-level governance challenge that involves many interdependencies and actors with different perceptions, goals, and approaches. This study, therefore, examines approaches of a set of European Union (EU) member states (Denmark, Finland, Germany, Italy, the Netherlands, and the United Kingdom (England)) to pursue a more coordinated approach to CCA policy. It specifically addresses the co-ordination approaches that the selected countries use for the development and implementation of their national CCA policies in the immediate period following the publication of the EU’s 2013 Adaptation Strategy. The analysis demonstrates that while useful coordination processes have been established in the analyzed EU member states, they have difficulty in challenging existing institutional hierarchies and decision rules. Consequently, longer-term opportunities for managing CCA conflicts and synergies among sectoral policies have to date been limited.
Velocity Field around a Rigid Flapping Wing with a Winglet in Quiescent Water

This study investigated the effect of a winglet on the velocity field around a rigid flapping wing. Two-dimensional particle image velocimetry was used to capture the velocity field of asymmetric one-degree-of-freedom flapping motion. A comparison was conducted between wings with and without a winglet at two flapping frequencies, namely 1.5 and 2.0 Hz. The effect of the winglet on the velocity field was determined by systematically comparing the velocity fields for several wing phase angles during the downstroke and upstroke. The presence of a winglet considerably affected the flow field around the wingtip, residual flow, and added mass interaction. The added mass was lower and residual flow was weaker for the wings with a winglet than for the wings without a winglet. The added mass and velocity magnitudes of the flow field increased proportionally with the flapping frequency.
Genetic Diversity of Egyptian Date Palms (Phoenix dactylifera L.) Using Morphological and Molecular Markers

Morphological and molecular analyses were conducted to evaluate the genetic diversity among eleven Egyptian date palms (Phoenix dactylifera L.). Ten SSR primer pairs revealed a high percentage of polymorphism (97.4%) among 38 total number of alleles, while 11 SCoT primers produced 48.5% from 171 amplified fragments. SCoTs recorded effective multiplex ratio (EMR) and PIC values of 7.5 and 0.14, respectively, opposing to 3.7 and 0.26 for SSRs, respectively. A similar marker index has thus resulted in both markers. Nei’s gene diversity (h) was generally low for both marker systems indicating homogeneous nature and narrow genetic background for the studied Egyptian date palms, which was also emphasized through their high genetic similarity estimates. The results of UPGMA cluster analysis and PCoA grouped the eleven date palms according to their geographical location and sex. In addition to classical morphological characters, the current study confirmed the importance of using SCoTs as functionally gene-based multi-loci markers besides nuclear SSR loci to assess the genetic variations and cultivar identification among Egyptian date palm genotypes
SPECIFIC FEATURES OF DECISION MAKING IN THE RECONSTRUCTION PROJECTS OF MUNICIPAL WATER SUPPLY SYSTEMS

The article considers the urgent problem for Ukraine – the development of decision making while managing the reconstruction projects of water supply systems. The analysis of the specific features of such systems and their influence on the processes of decision making in planning and managing of reconstruction projects are shown. The concept of value-driven decision making in the reconstruction projects of water supply systems is suggested. The model for project ranging on the basis of the integrated estimation of projects social benefits based on the use of modified weighed sum method and the project state assessment with the help of neural network classifier is developed. This model allows taking into account the value-driven features during the process of solving the semi structured problem of ranging projects in a portfolio. Also the model that allows determining the optimal content of the portfolio based on the knapsack problem solving and reckoning in value generated by each project is proposed. On the basis of the fulfilled research of structural and informational models of automated decision support system in project management of water supply systems reconstruction is built. The software based on the use of artificial neural network with back propagation, weighed sum method and the model for adding projects to the portfolio based on the information about available resources is developed. The software makes it possible to reduce project schedules and increase the efficiency of communication between project stakeholders.
Cancer Patients’ Perspectives on Integrating Cancer Care in Primary Care Settings: A Qualitative Inquiry

Introduction: Research has demonstrated the importance of general practitioners in providing care for cancer patients within the concept of ‘care closer to home’. This study reports cancer patients’ views and expectations on integrated cancer care in primary care settings in Brunei. Methods: A qualitative approach using semi-structured in-depth interviews with cancer patients were conducted. The interviews were recorded, transcribed, and analysed using thematic analysis. Results: 13 cancer patients participated and were interviewed, leading to three key themes that emerged from this study: (i) perceived challenges for providing cancer care at primary care settings; (ii) current health care system favours hospital-based cancer care and (iii) expectations towards integration of cancer care into primary care. Conclusion: Participants expressed their acceptance to the concept of primary care-based cancer care, mainly due to convenience and minimised waiting time. For this to be in place, there is a need for stronger communication channels between general practitioners and hospital physicians, familiarity of patients’ cases among general practitioners, in-depth knowledge and experience of general practitioners in cancer care, and consulting the same general practitioners to provide continuity of care.