Miracle-dz/UniFAR-FTUs huggingface dataset:
Fos Localization in Cytosolic and Nuclear Compartments in Neurones of the Frog, Rana esculenta, Brain: An Analysis Carried Out in Parallel with GnRH Molecular Forms

C‐fos activity was determined in the brain of the frog, Rana esculenta, during the annual sexual cycle. The localization of GnRH molecular forms (mammalian‐ and chicken‐GnRHII) was also carried out to determine whether or not the proto‐oncogene and the peptides showed a functional relationship. Northern blot analysis of total RNA revealed the presence of a single strong signal of c‐fos like mRNA of 1.9 Kb during February and April. This was followed by expression of c‐Fos protein (Fos) in several brain areas during March and July shown by immunocytochemistry. In particular, the olfactory region, the lateral and medial pallium, the nucleus lateralis septi, the ventral striatum, the caudal region of the anterior preoptic area, the suprachiasmatic nucleus, the ventral thalamus, tori semicircularis and ependymal layers of the tectum were immunostained. There was no overlap between Fos immunoreactive perikarya and GnRH immunoreactive perikarya (e.g. gonadotrophin‐releasing hormone (GnRH) in the rostral part and Fos in the caudal region of the anterior preoptic area). Interestingly, a cytoplasmic localization of Fos was also observed by immunocytochemistry and gel retardation experiments supported this observation. Cytoplasmic extracts from September–October animals bound the AP1 oligonucleotide. The complex was not available in the nuclear extracts from the same preparation, suggesting that, besides Fos, Jun products were also present. Conversely, nuclear but not cytosolic binding was detected in the brain of animals collected in July. In conclusion, we show that Fos and GnRH activity does not correlate in the frog brain and, for the first time in a vertebrate species, we give evidence of a cytoplasmic AP1 complex in neuronal cells.
Ejecución, la parte difícil de la estrategia

Si bien el desarrollo de las teorias sobre estrategia ha sido dramatico, una parte crucial para el exito de la estrategia viene a ser la ejecucion. En este ensayo, se revisan las razones del fracaso de empresas tanto en la formulacion como en la implantacion de la estrategia. Se constata que para una buena ejecucion es importante dotarse de recursos valiosos; para tener exito en un mundo en constante cambio, las empresas deben ser capaces de reaccionar con presteza, el exito en ultima instancia, radica en la capacidad del lider de integrar los recursos y capacidades a la implantacion de la estrategia, creando asi, un sistema de actividades que sea indescifrable para la competencia.
Contribution of interleukin‐1β to the inflammation‐induced increase in nerve growth factor levels and inflammatory hyperalgesia

1 Peripheral inflammation is associated with the local production of neuroactive inflammatory cytokines and growth factors. These may contribute to inflammatory pain and hyperalgesia by directly or indirectly altering the function or chemical phenotype of responsive primary sensory neurones. 2 To investigate this, inflammation was produced by the intraplantar injection of complete Freund's adjuvant (CFA) in adult rats. This resulted in a significant elevation in interleukin‐ip (IL‐1β) and nerve growth factor (NGF) levels in the inflamed tissue and of the peptides, substance P and calcitonin gene‐related peptide (CGRP) in the L4 dorsal root ganglion 48 h post CFA injection. 3 The effects of a steroidal (dexamethasone) and a non‐steroidal (indomethacin) anti‐inflammatory drug on the levels of NGF and IL‐1β in inflamed tissue were investigated and compared with alterations in behavioural hyperalgesia and neuropeptide expression in sensory neurones. 4 Systemic dexamethasone (120 μg kg−1 per day starting the day before the CFA injection) had no effect on the inflammatory hyperalgesia. When the dose was administered 3 times daily, a reduction in mechanical and to a lesser extent thermal sensitivity occurred. Indomethacin at 2 mg kg−1 daily (i.p.) had no effect on the hyperalgesia and a dose of 4 mg kg−1 daily was required to reduce significantly mechanical and thermal hypersensitivity. 5 The increase in NGF produced by the CFA inflammation was prevented by both dexamethasone and indomethacin, but only at the higher dose levels. Dexamethasone at the lower and higher dose regimes diminished the upregulation of IL‐1β whereas indomethacin had an effect only at the higher dose. 6 The increase in SP and CGRP levels produced by the CFA inflammation was prevented by dexamethasone and indomethacin at the lower and higher dose regimes. 7 Intraplantar injections of IL‐1β (0.01, 0.1 and 1 ng) produced a brief (6 h) thermal hyperalgesia and an elevation in cutaneous NGF levels which was prevented by pretreatment with human recombinant IL‐1 receptor antagonist (IL‐1 ra) (0.625 μg, i.v.). The thermal hyperalgesia but not the NGF elevation produced by intraplantar IL‐1β (1 ng) was prevented by administration of a polyclonal neutralizing anti‐NGF serum. 8 IL‐1 ra significantly reduced the mechanical hyperalgesia produced by CFA for 6 h after administration as well as the CFA‐induced elevation in NGF levels. Anti‐NGF pretreatment substantially reduced CFA‐induced mechanical and thermal hyperalgesia without reducing the elevation in IL‐1β. 9 Intraplantar NGF (0.O2, 0.2 and 2 μg) injections produced a short lasting thermal and mechanical hyperalgesia but did not change IL‐1β levels in the hindpaw skin. 10 Our results demonstrate that IL‐1β contributes to the upregulation of NGF during inflammation and that NGF has a major role in the production of inflammatory pain hypersensitivity.
English Word Reading Difficulties and Orthographic Processing Weaknesses in Chinese–English Bilingual Adolescents With Dyslexia

Is dyslexia in Chinese for Chinese–English bilinguals associated with difficulties in reading English, given differences in L1 and L2 orthographies? Among 11 Hong Kong Chinese adolescents with dyslexia, who were diagnosed by professional psychologists using the diagnostic criteria set out in a standardized test, and 14 adolescents without dyslexia, Chinese word reading was tested at the age of 9 years; English word reading was tested across ages 9, 10, 11, and 12 years; and English orthographic processing was tested in a lexical decision task at the age of 13 years. The lexical decision task required participants to judge whether or not stimuli appeared to “look like” a possible real word in English across 3 conditions (real words, look-like words that were orthographically possible in English, and nonwords that violated orthographic rules of English). English word reading differed significantly between the 2 groups in 2 of the 4 years. Both groups found it easier to identify nonwords that violated English orthographic rules than those that did not. However, compared with peers without dyslexia, adolescents with dyslexia had more difficulties with English orthographic rules in accuracy but not reaction time, suggesting that children with dyslexia may manifest specific difficulties in English orthographic processing.
Husserl and the Fact of Practical Reason – Phenomenological Claims toward a Philosophical Ethics

The thesis of this paper is that Husserl, in his later ethics, reinterprets the philosophical content that discloses itself in the Kantian conception of a “fact of practical reason”. From 1917/18 on, Husserl increasingly ceases to pursue his initial idea of a scientific ethics. The reason for this move lies precisely in the phenomenological analysis of “Gemutsakte”, through which two main features of the fact of practical reason impose themselves more and more on Husserls thought: the personal concernment/obligation and the primacy of the practical with the coeval call for universal validity. Husserl recognizes that the form of ethical facticity or entanglement cannot be grasped by a science of evidence, which speaks objectively and non-personally (apersonal) of acts of willing, valuing or preferring. Husserl thus gets to a reinterpretation of the fact of practical reason as the philosophical nucleus of his ethics, which is now a personal and affective ethics. He bestows a texture on this fact, however not as he would have thought in the first place: not as evident laws of a material apriori of “Gemut”. In the person and her ethical experience as absolute affection Husserl rather discovers that which is per se not objectifiable and not to be made rationally evident. By this, Husserl captures and phenomenologically explains the non-objectifiable source of obligation and the possibility of complying with it.
A confusing case – Weissella confusa prosthetic joint infection: A case report and review of the literature

This article describes a case involving a 94-year-old woman with an infection of her knee, which had previously undergone total knee arthroplasty. Following culture of aspirate from the knee, the causative organism was tentatively identified as a Lactobacillus species. The infection was later determined to be caused by Weissella confusa. The authors discuss the difficulties in identifying W confusa and present a literature review of infections caused by the species.
Modélisation et caractérisation de capteurs mécaniques intégrés à base d'hétérostructures A1GaN/GaN pour les environnements hostiles

Certains domaines d'applications tels que l'aerospatial, l'automobile ou le forage de haute profondeur peuvent necessiter la visualisation de certains parametres physiques dans des environnements hostiles. Les capteurs microelectroniques bases sur le silicium y atteignent souvent leurs limites, qui sont qualifiees de conditions « severes ». Ce travail se base principalement sur l'etude de solutions de capteurs mecaniques fonctionnant en conditions severes. Le principe de ces capteurs repose sur l'exploitation de transistors de mesures HEMT a base de nitrures III-V (III-N), a la fois piezoelectriques et semiconducteurs, qui reste stable en conditions severes. La comprehension des interactions entre physique des semiconducteurs et physique des materiaux ainsi que la caracterisation de structures possibles pour la detection mecanique representent les principaux enjeux de ce sujet de these. La modelisation mecanique analytique et numerique des structures etudiees a permis d'apprehender le comportement de structures piezoelectriques multicouches. Le couplage de ce modele electromecanique avec un modele electronique du capteur a permis d'etablir la faisabilite du principe de detection ainsi que la linearite de la reponse du capteur. La caracterisation des prototypes realises en cours de these ont corrobore la linearite du capteur tout en faisant apparaitre l'influence de nombreux effets parasites reduisant sa sensibilite a savoir les effets de resistance parasites et de piezoresistances variables.
The hermetic nature of linguistic research: A note to Jackendoff

Abstract The hermetic, exclusionary stance of formal linguistic research towards relevant data condemns the linguistic enterprise to irrelevance. The procedures and principles of evolutionary biology are excluded from discussions of the evolution of language. Stories are instead crafted to fit speculation. Although human speech is a central element of our linguistic capacity, the findings of studies of speech are thought to be outside the domain of linguistic research. Well attested facts such as the formant frequency relationships that characterize vowels are ignored. Phonological studies continue to use binary coded tongue positions that neither describe the relationships that hold between vowels, or predict the direction of sound changes. Linguists generally continue to hold to the premise that a domain specific “faculty” of the brain exists, contrary to the findings of neurophysiologic studies that demonstrate linkages between the neural bases of motor control, cognition and language. A “Universal Grammar” continues to be a core property of linguistic theory, despite evidence to the contrary from genetic, behavioral and these neurophysiologic studies.
High-dose ustekinumab for severe childhood deficiency of interleukin-36 receptor antagonist (DITRA)

Deficiency of the interleukin-36 receptor antagonist (DITRA) is an autosomal recessive disease caused by mutations of IL36RN gene.1 Patients suffer from flares of acute generalised pustular psoriasis and systemic inflammation. We present two paediatric cases of DITRA with a severe clinical course, resistant to multiple therapies in whom the use of high doses of ustekinumab (a monoclonal antibody against the p40 subunit of both IL-12 and IL-23) lead to a persistent control of the disease. A 4-year-old boy, born from unrelated parents, presented at the age of 3 years with inverse psoriasis in the genital area. After some months, he developed diffuse pustular lesions associated with fever, elevation of acute phase reactants and poor general condition, requiring parenteral antibiotics and high-dose steroids (figure 1). Compound heterozygosity for the IL36RN P76L/S113L mutations was detected. Different treatments (acitretin, high-dose ciclosporin, …
Achtsam essen: Achtsamkeitsschulung kann Essstörungen überwinden helfen

Zusammenfassung Achtsamkeit bedeutet die Wahrnehmung und Bewusstmachung des gegenwartigen Moments ohne zu urteilen. Essen ist heute oft von Gewohnheiten bestimmt, ihm wird wenig Aufmerksamkeit geschenkt. Da Essen auch mit sinnlicher Wahrnehmung und Wertschatzung einhergeht, kann sich eine Schulung der Achtsamkeit bei Essstorungen positiv auswirken. Der Beitrag informiert uber die Hintergrunde und die Moglichkeiten in der Praxis.
Double-Bundle Anterior Cruciate Ligament Reconstruction

Background The biomechanical function of single-bundle anterior cruciate ligament reconstruction, in cadaveric studies, is successful in limiting anterior tibial translation in response to an anterior tibial load but seems to be insufficient to control a combined rotator load of internal and valgus torque. Anatomical double-bundle anterior cruciate ligament reconstruction might produce a better biomechanical outcome. Hypothesis The addition of the posterolateral bundle to the anteromedial bundle, in an in vivo double-bundle computer-assisted anterior cruciate ligament reconstruction, is able to reduce internal rotation of the tibia at 30° of knee flexion, compared with a standard single-bundle reconstruction. Study Design Controlled laboratory study. Methods Twenty consecutive anterior cruciate ligament reconstructions were performed in male patients in April and May 2006 with double-bundle gracilis and semitendinosus tendon grafts using the 2.0 OrthoPilot navigation system. Group A (10 patients) underwent standard single-bundle anterior cruciate ligament reconstruction with doubled gracilis and semitendinosus tendon graft; group B (10 patients) underwent double-bundle reconstruction with doubled gracilis and semitendinosus tendon graft. Anteroposterior displacement and internal and external rotation at 30° of knee flexion were evaluated before and after reconstruction, using manual maximum force. Results Both techniques significantly reduced anteroposterior displacement and internal and external rotation of the tibia with respect to preoperative anterior cruciate ligament–deficient condition (P < .05). Comparing groups, no differences in anteroposterior tibial displacement and internal and external rotation of the tibia were found (anteroposterior, 3.7 mm and 5.2 mm; internal rotation, 16.3° and 16.6°; external rotation, 15.7° and 15.1°, respectively) in group A and B (P = .06, .90, and .72, respectively). Conclusion The hypothesis that addition of the posterolateral bundle to the anteromedial bundle is able to reduce internal rotation of the tibia at 30° of knee flexion is not confirmed. Clinical Relevance The effective role of the anatomical double-bundle procedure in better restoring knee kinematics should be questioned in an in vivo model.
Smoking and cancer of the uterine cervix: hypothesis.

Hypothesizing that squamous cell tumors of various sites will be associated with cigarette smoking, and that site-specific cancers with predominant squamous cell histology will be strongly associated, it could be expected that cervical cancer will be strongly associated with cigarette smoking. Reports of studies bearing on this association are reviewed, concluding that smoking as a risk factor in cervical cancer has not received as much attention as it should, and all of the "established" risk factors such as marital instability, and age at 1st pregnancy or coitus are unlikely to be very useful for primary prevention, at least in the near future. It would thus appear to be useful to reexamine the smoking-site specific cancer associations, controlling for tumor cell type.
Manifestations exécutives et de la théorie de l'esprit dans l'évaluation langagière des cérébrolésés

Les sujets cerebroleses sans aphasie presentent souvent des troubles langagiers specifiques liees a des difficultes executives et/ou de theorie de l'esprit. Actuellement, les batteries habituelles d'evaluation du langage ne permettent pas d'analyse fine de ces troubles langagiers. Afin d'etudier les interactions entre fonctions executives et langage, et les manifestations de la theorie de l'esprit dans un discours contraint, notre etude a ainsi vise a normaliser de maniere quantitative et qualitative, chez un echantillon de 90 sujets temoins de 40 a 60 ans, trois tests mettant en jeu langage et fonctions executives : les fluences verbales, le Hayling Test ainsi que le Dice Game. Dans un debut de validation, nous avons compare les resultats de 7 patients cerebroleses non aphasiques sur ces epreuves, a ceux obtenus a des tests executifs equivalents non langagiers (fluences graphiques, BAWL, TMT) et a une epreuve de theorie de l'esprit (test des faux-pas).
A new LMI representation of LQR based voltage control of grid-connected wind farm

As the penetration of wind energy and the size of modern wind farms continue to increase, the voltage control at a specified remote location becomes increasingly important for stable and reliable operation of electric grid. This paper presents a new voltage control scheme that is based on the linear quadratic regulator (LQR) controller formulated as a linear matrix inequality (LMI) problem. The main advantage of using the LMI-based approach is that it is readily applicable for robust tuning considering a range of operating conditions. A candidate wind farm site on Vancouver Island, Canada, is considered. The proposed controller and its design methodology are shown to be very effective for the systems with multiple wind turbines as well as readily applicable to larger wind farms of different configurations
Online Decoupled Stator and Rotor Resistances Adaptation for Speed Sensorless Induction Motor Drives by a Time-Division Approach

The paper addresses the method for stator and rotor resistance identification in speed sensorless induction motor drives. The instability problem caused by pure integration of the voltage model (VM) of rotor flux is handled by introducing correction terms in the VM. It is, however, shown that the third-order persistent excitation (PE) condition for simultaneous identification of stator, rotor resistances and rotor speed can barely be satisfied even with extra excitations in rotor flux modulus command. And an adaptive observer that is not persistently excited may become instable when exposed to bounded disturbances. Hence, to design a robust flux observer, concept of time-division multiplexing is incorporated into the observer design. That is, stator resistance is identified as the flux modulus is flat, while rotor resistance is adapted as a ramp flux modulus command is applied. This relaxes PE condition to order two, and as a drawback, the ramp flux modulus command incurs speed ripples. The decoupled identifiability of stator resistance is designed and explained, a rigorous input-to-state stability analysis of both the mismatch [between VM and current model (CM)] and the error (between actual rotor flux and CM) is set forth, and a convergence analysis of parameters is elaborated. To validate the feasibility, simulation and experiment results are included in the text as well.
Walking tests for stroke survivors: a systematic review of their measurement properties

Purpose: To provide an overview of walking tests including their measurement properties that have been used in stroke survivors. Method: Electronic databases were searched using specific search strategies. Retrieved studies were selected by using specified inclusion criteria. A modified consensus-based standards for the selection of health status measurement instruments (COSMIN) checklist was applied for methodological quality assessment of the included studies. A quality assessment for statistical outcomes was used to assess measurement properties of the walking tests. Tests that were included were categorized according to the framework of the international classification of functioning, disability and health (ICF). Results: Thirty-two studies, evaluating 23 walking tests, were included. The tests assessed walking using the outcome measures of walking speed, walking distance, functional ambulation and walking on different surfaces. The methodological design and statistical methods of most studies evaluating reliability and criterion validity were sufficient, and found the outcome measures to be reliable and valid. However, data on measurement error, minimal important difference and minimal important change were lacking and responsiveness was correctly evaluated in one study only. Conclusions: Many walking tests have been clinimetrically evaluated in stroke survivors. Most walking tests were found to be reliable and valid. Implications for Rehabilitation Many tests assessing walking in stroke survivors are available in the literature. The Six Minute Walk Test, Ten Metre Comfortable Walk Test, Ten Metre Fast Walk Test, Functional Ambulation Categories and Six Metre Walk Test on parquet and carpet have been most frequently clinimetrically evaluated. These tests amongst others, have been shown to be valid, reliable and feasible for stroke survivors. With the wide variety of walking tests, it is important to choose an appropriate walking test suiting the specific aim of the clinician or researcher.
Greimas’s semiotic square and Greek and Roman astrology

La tentative de Greimas pour baser sa structure elementaire de la signification sur le carre logique d'Apuleius a ete souvent critiquee pour son manque de clarte et de rigueur logique. L'A. montre ici que le carre de Greimas est en effet limite dans ses applications, mais qu'il a d'interessantes relations avec une autre structure logique, differente des groupes keiniens et piagetiens auxquels il se refere. En examinant cette structure dans deux nouveaux contextes (l'astrologie occidentale et les termes de couleur), il montre que le carre semiotique represente toujours un motif cosmologique et symbolique, mais qu'il est plus productif sans connexion avec le carre logique d'Apuleius/Aristote