Miracle-dz/UniFAR-FTUs huggingface dataset:
Three‐base deletion mutation c.120_122delGTT in ATP2A2 leads to the unique phenotype of comedonal Darier disease

Darier disease (DD; Darier―White disease; OMIM 124200) is an autosomal dominant inherited disorder. 1 Clinically, it is characterized by recurrent and multiple hyperkeratotic papules or nodules affecting the trunk and flexural aspects of the extremities. 1 Characteristic histopathological features are dyskeratotic cells in the form of corps ronds and grains, suprabasal acantholysis forming suprabasal lacunae and irregular upward proliferation into the lacunae of papillae lined with a single layer of basal cells, the so-called villi. 2 The causative gene is ATP2A2 (OMIM 108740) on chromosome 12, which encodes the sarco/endoplasmic reticulum calcium pump ATPase (SERCA2). 2 Clinical variants include the hypertrophic, vesiculobullous, hypopigmented, cornifying, zosteriform and linear subtypes, and the rare subtype comedonal Darier disease (CDD). 1,3―6 CDD tends to appear in seborrhoeic areas. The characteristic morphological features are prominent follicular involvement, sometimes associated with keratotic plugs, and the presence of greatly elongated dermal villi and papillary projections. 4 There have been no conclusive reports on the aetiology of CDD and it is still controversial as to whether or not CDD is a variant of DD, and if it is caused by ATP2A2 gene mutations, although a combination of CDD and classic DD was reported in one patient. 7 The present study identifies a previously unreported three-base deletion mutation in ATP2A2 in a patient with CDD.
Marketing illegitimacy within SMEs: learning triggers and influence on marketing communications

ABSTRACT In line with Institutional Theory, this study introduces the concept of marketing illegitimacy to critically investigate how SME owner/managers perceive the usefulness of marketing principles and practices. The study also investigates the antecedents and consequences of these perceptions. Firstly, the study hypothesizes that negative perceptions about marketing decrease when negative performance increases, entrepreneurs look for any possible solution to achieve their goals. Secondly, the study hypothesizes that a high level of marketing illegitimacy negatively influences SME owner/managers’ willingness to broaden the range of marketing communication activities. Building upon a sample of 78 companies, results confirm the validity and reliability of the measurement instrument and the two hypothesis, thus shedding some light on the underlining mechanisms of the marketing adoption pattern within SMEs. Theoretical and managerial implications of the findings are discussed and future research avenues are suggested.
Validation and reliability of the New Lifestyles NL-1000 accelerometer in New Zealand preschoolers.

BACKGROUND Objective measures, such as accelerometers, are increasingly being used to measure physical activity (PA) levels in children, and the use of validated and reliable instruments is desirable when measuring the effectiveness of programs. The purpose of this study was to determine the validity and reliability of the New Lifestyles NL-1000 accelerometer among preschoolers using a modified version of the Children's Activity Rating Scale (CARS). METHODS Fourteen preschoolers wore the NL-1000 at their waist while the device measured activity levels [in seconds of moderate-to-vigorous physical activity (MVPA)]. They were also videoed for approximately 12 minutes while participating in normal activities at an early childhood center. At approximately 2-minute intervals, activity level readings derived from the NL-1000 were recorded. The video footage was analyzed using a modified CARS technique and the CARS scores compared with data obtained from the accelerometer. RESULTS Within subject reliability was measured using intraclass correlation coefficients (0.58 for CARS and 0.59 for NL-1000). Furthermore, 95% of the variation in CARS could be explained by variation in the accelerometer counts, with 2.4% of the variation being participant-specific. CONCLUSION The NL-1000 is a sufficiently reliable and valid tool for assessing MVPA in preschoolers.
Biologia Plantarum Xx (x): Xxx-xxx, 20xx Characterization of the High-affinity Phosphate Transporter Pht1;4 Gene Promoter of Arabidopsis Thaliana in Transgenic Wheat

The root specificity and phosphate (Pi) deficiency responsiveness of high-affinity phosphate transporter (PHT1) genes point to their promoters as a sustainable system to drive Pi acquisition-related transgenes in plants. In this study, a 3-kb promoter of the AtPHT1;4 gene from Arabidopsis thaliana fused to the GUS reporter gene was biolistically introduced into wheat (Triticum aestivum L.) and functionally characterized in transgenic plants grown in hydroponics and in pots with soil under various Pi supply rates. From among 27 T 1 progeny derived from 250 T 0 , four transgenic lines reached T 3 , with two of them showing detectable GUS activity in the roots of T 4 plants. An unusually high number of transgene insertions characterized these transgenic lines, along with an irregular pattern of histochemical GUS staining and weak GUS activity. GUS expression driven by AtPHT1;4 was consistently higher under most assayed conditions, as it was unaffected by 0 to 0.5 mM Pi in hydroponically grown plants, as well as by 16 to 20 mg(P) kg-1 (soil) in potted plants. Raising the soil P up to or above 40 mg kg-1 significantly down-regulated the quantity of GUS transcripts. These results show that the responsiveness of the AtPHT1;4 promoter to Pi availability in transgenic wheat was restricted to soil-grown plants, which highlighted the relevance of the substrate and Pi supply rates in assessing molecular responses to Pi deficiency.
Optimization of NEMS pressure sensors with a multilayered diaphragm using silicon nanowires as piezoresistive sensing elements

A pressure sensor with a 200 µm diaphragm using silicon nanowires (SiNWs) as a piezoresistive sensing element is developed and optimized. The SiNWs are embedded in a multilayered diaphragm structure comprising silicon nitride (SiNx) and silicon oxide (SiO2). Optimizations were performed on both SiNWs and the diaphragm structure. The diaphragm with a 1.2 µm SiNx layer is considered to be an optimized design in terms of small initial central deflection (0.1 µm), relatively high sensitivity (0.6% psi−1) and good linearity within our measurement range.
NSAIDs Modulate Morphine Transport at the Blood-Brain Barrier: A Role for P-glycoprotein

Our laboratory has previously demonstrated that experimental peripheral inflammatory pain (PIP), induced by subcutaneous plantar injection of λ-carrageenan in Sprague Dawley rats, results in increased expression and activity of the ATP-dependent efflux transporter P-glycoprotein (P-gp) that is endogenously expressed at the blood-brain barrier (BBB). Increased P-gp functional expression was associated with a significant reduction in CNS uptake of morphine and, subsequently, reduced morphine analgesic efficacy. The present study examined whether the PIP-induced increase in P-gp functional expression was due to changes in intracellular trafficking (i.e., localization of P-gp), mediated by changes in the association of P-gp and caveolin-1, a key trafficking protein. These studies also determined if the drug diclofenac, a non-steroidal antiinflammatory (NSAID) that is commonly administered in conjunction with opioids during peripheral inflammatory pain (PIP), altered or modulated P-gp functional expression providing evidence of a drug-drug interaction. Confocal microscopy and subcellular fractionation revealed that under conditions of PIP, the disassembly of high-molecular weight P-gp-containing structures result in an increase in P-gp ATPase activity and changes in the localization of P-gp. Western blot analysis demonstrated further an increase in P-gp expression in rat brain microvessels following PIP induction and also after diclofenac treatment alone in the absence of PIP. Additionally, in situ brain perfusion studies showed that both PIP and diclofenac treatment alone increased P-gp efflux activity resulting in decreased radiolabeled-
Discrete reduction patterns of parvalbumin and calbindin D-28k immunoreactivity in the dorsal lateral geniculate nucleus and the striate cortex of adult macaque monkeys after monocular enucleation

Abstract We analyzed the immunohistochemical distribution of the two calcium-binding proteins, parvalbumin (PV) and calbindin D-28k (CB), in the primary visual cortex and lateral dorsal geniculate nucleus (dLGN) of monocularly enucleated macaque monkeys (Macaca fascicularis and Macaca nemestrind) in order to determine how the expression of PV and CB is affected by functional inactivity. The monkeys survived 1–17 weeks after monocular enucleation. The distribution pattern of each of the proteins was examined immunocytochemically using monoclonal antibodies and compared with that of the metabolic marker cytochrome oxidase (CO). We recorded manually the number of immunostained neurons and estimated the concentration of immunoreactive staining product using a computerized image-acquisition system. Our results indicate a decrease of approximately 30% in the labeling of PV-immunoreactive (ir) neuropil particularly in those layers of denervated ocular-dominance columns receiving the geniculocortical input. There was no change in the number of PV-ir neurons in any compartment irrespective of the enucleation interval. For CB-ir, we found a 20% decrease in the neuropil labeling in layer 2/3 of the denervated ocular-dominance columns. In addition, a subset of pyramidal CB-ir neurons in layers 2 and 4B, which are weakly stained in control animals, showed decreased labeling. In the dLGN of enucleated animals, PV-ir and CB-ir were decreased only in the neuropil of the denervated layers. From these results, we conclude that cortical interneurons and geniculate projection neurons still express PV and CB in their cell bodies after disruption of the direct functional input from one eye. The only distinct decrease of PV and CB expression is seen in axon terminals from retinal ganglion cells in the dLGN, and in the axons and terminals of both geniculocortical projection cells and cortical interneurons in the cerebral cortex.
Collaborative target tracking in wireless sensor network

Along with the development of communication, computer technology, networking and sensor technology, the wireless sensor network (WSN) has received the widespread attention. Target tracking is one of the most important applications of WSN. The key technologies about target tracking in WSN are introduced. The interacting multi-Model (IMM) algorithm and the particle filtering algorithm are developed for collaborative target tracking. A simulation platform is built up to confirm the performance of the proposed collaborative target tracking algorithms. The simulation result shows that the proposed method is reasonable and feasible.
Integrating rules and connectionism for robust commonsense reasoning by Ron Sun, John Wiley & Sons, New York, 1994, pp 273, £49.50, ISBN 0-471-59324-9

The first is Turing's insistence that the computer has a hardware system that would be as simple as possible. Turing's philosophy being that the main functionality of the ACE computer would be achieved by programming rather than complex electronic circuitry. The trend in computer architectures since the publication of this report has been towards more and more complex hardware. However, the inevitable result of this has been the computer becoming increasingly baroque and inefficient. This has resulted in a new generation of very powerful Reduced Instruction Set Computers which, while not exactly matching Turing's Spartan hardware design, are conceptually much nearer to it than the vast majority of the computer architectures that have been designed over the last three decades.
THE SIGNIFICANCE OF THE VESSELS OF THE SKIN IN ESSENTIAL HYPERTENSION.

Evidence of a varied nature has led to the widely accepted conclusion that one of the significant factors leading to elevation of the blood pressure in essential hypertension is constriction of the arterioles. A thorough review of the literature dealing with this problem has recently been published by Fishberg (1) and tends to show that the most important vascular territory involved in this mechanism is the splanchnic region. The evidence is, as has been said, varied. As long ago as 1875 Litten (2) observed that tying off the superior mesenteric artery in dogs was followed promptly by rise of arterial pressure of from twenty to twenty-five millimeters of mercury. The elevation frequently persisted for several hours. Longcope and McClintock (3, 4) demonstrated that compression of the coeliac axis and superior mesenteric arteries in dogs is followed by temporary increase of the blood pressure. Jansen, Tams and Achelis (5) repeated these experiments and essentially confirmed their results. They observed further that cold colonic irrigations in normal individuals were followed by much greater rises in blood pressure than were cold baths although in the case of colonic irrigations constriction probably involved only the colonic section of the splanchnic vessels, whereas in cold baths nearly all the vessels of the skin were affected. They found that binding the extremities of normal persons with elastic bandages caused only an insignificant rise in blood pressure but that in individuals suffering from essential hypertension it was attended by marked elevation of the arterial tension. This phenomenon was interpreted as indicating that in patients with arterial hypertension reduction in the degree of distensibility of the splanchnic vessels resulted in failure to attain normal compensatory dilata-tion following constriction of peripheral vessels. In extensive studies on the action of pressor substances prepared from the plasma of normal and hypertensive individuals Page (6) found likewise that it was constriction of the blood vessels of the splanchnic region that was chiefly responsible for rise in blood pressure on injection of such substances into animals. Similarly , it has long been known that the vessels of the splanchnic region are most important in the rise of blood pressure following injections of adrena-895 Downloaded from
Risk Taking Among Diabetic Clients

Diabetic clients must make daily decisions about their health care needs. Observational and anecdotal evidence suggests that vast differences exist between the kinds of choices diabetic clients make and the kinds of chances they are willing to take. The purpose of this investigation was to develop a diabetic risk-assessment tool. This instrument, which is based on subjective expected utility theory, measures risk-prone and risk-averse behavior. Initial findings from a pilot study of 18 women clients who are on insulin indicate that patterns of risk behavior exist in the areas of exercise, skin care, and diet.
Adult Male Nutrition and Reproductive Success in Drosophila melanogaster

Abstract Explanations for the maintenance of variation in reproductive traits influenced by seminal fluid accessory gland proteins (Acps) in male Drosophila melanogaster include nontransitivity in the outcome of sperm competition and/or condition dependence of the traits involved. We investigated the effects of adult male nutrition (five diets) on the expression of Acp- and sperm- mediated traits. We found novel, nonlinear effects, with females showing lower levels of refractoriness to remating after mating with males held on the lowest and highest yeast diets. There were no significant effects of adult male nutrition on male paternity share, but there was a striking, nonlinear effect on second male progeny production, with males kept on intermediate yeast diets fathering the highest number of offspring. Such “bell shaped” responses of life-history traits to nutrition have only previously been reported for longevity. Consistent with previous reports, males maintained on low protein diets had lower premating success and gained fewer rematings with nonvirgins. We show novel and body size independent effects of adult male nutrition on traits influenced by Acps and sperm, which do not fit current condition-dependent handicap models and can affect the strength of sexual selection acting upon such fitness-related traits.
The Five Themes of Change Management

As Kotter commented, a change is required to build an organization that wins in both the present and the future. However, for change to be successful, it should take the culture aspects into consideration. Hence, this research brought the cultural component under full investigation in terms of both the national and organizational cultures by utilizing Hofstede’s 6-Dimension Model and Hofstede Multi-Focus Model. The purpose is to provide a new culture-based change management model. The new model is called ElKattan’s 5-Theme Model. The model tackles a number of pitfalls in the existing models like Lewin’s 3-Phase Model and Kotter’s 8-Step Model. The study used a qualitative research design in a context of two medium-sized companies in Egypt. In order to assess the influence of the culture on the change, the organizational culture was measured using a survey that is based on the Hofstede Multi-Focus Model. The research showed how a lack of practicing the components of the 5-Theme Model led to failure in implementation. This paper provides a comprehensive model of how organizational change should be managed by medium-sized companies in any industry globally. The model suggests a number of components that must be practiced during the different phases of the implementation. The model provides managers with a complete practical toolkit that can be used while managing the change during the different phases of the implementation. The model provides integration between change, strategy, project management, and culture. To the researcher’s knowledge, no such model is available in change management literature.
Quantifying Potential Human Health Impacts of Animal Antibiotic Use: Enrofloxacin and Macrolides in Chickens

Use of similar or identical antibiotics in both human and veterinary medicine has come under increasing scrutiny by regulators concerned that bacteria resistant to animal antibiotics will infect people and resist treatment with similar human antibiotics, leading to excess illnesses and deaths. Scientists, regulators, and interest groups in the United States and Europe have urged bans on nontherapeutic and some therapeutic uses of animal antibiotics to protect human health. Many regulators and public health experts have also expressed dissatisfaction with the perceived limitations of quantitative risk assessment and have proposed alternative qualitative and judgmental approaches ranging from “attributable fraction” estimates to risk management recommendations based on the precautionary principle or on expert judgments about the importance of classes of compounds in human medicine. This article presents a more traditional quantitative risk assessment of the likely human health impacts of continuing versus withdrawing use of fluoroquinolones and macrolides in production of broiler chickens in the United States. An analytic framework is developed and applied to available data. It indicates that withdrawing animal antibiotics can cause far more human illness‐days than it would prevent: the estimated human BENEFIT:RISK health ratio for human health impacts of continued animal antibiotic use exceeds 1,000:1 in many cases. This conclusion is driven by a hypothesized causal sequence in which withdrawing animal antibiotic use increases illnesses rates in animals, microbial loads in servings from the affected animals, and hence human health risks. This potentially important aspect of human health risk assessment for animal antibiotics has not previously been quantified.
NAC: An Adaptive Case-Based Reasoning Tool for Experimenting with Retrieval and Indexing

Abstract : NAC is a testbed for experimenting with concepts of retrieval and indexing in Case-Based Reasoning (CBR). The paper describes similarity functions and decision functions used for retrieval as well as methods for re-indexing and case organization. The paper also describes methods for weighting attributes, analyzing their dependence and evaluating the importance index of a single stored case. Two examples of how to use NAC are provided. Methods employed for retrieval and indexing are based on mathematically sound techniques developed in classification, clustering and decision analysis. NAC includes basic functions for specifying similarity, normalizing data and evaluation. Retrieval is done using both nonparametric (e.g., nearest neighbor) and parametric (i.e., Bayesian) statistical procedures with weighted attributes. New indices for cases are generated using clustering methods. Cases are re-organizing using the new indices. NAC also allows the user to test the predictive accuracy of retrieval methods and the quality of indices generated in re-indexing. NAC includes adaptive functions for enhancing the performance of retrieval and indexing. Important functions for adaptation include weighting and selecting attributes, learning dependency relationships and calculating typicality for each stored case. The NAC environment was designed so that additional techniques and metrics can easily be added.
Chirality-dependent domain wall pinning in a multinotched planar nanowire and chirality preservation using transverse magnetic fields

Chirality-dependent pinning of magnetic domain walls (DWs) has been observed in a planar Ni81Fe19 nanowire with two spatially separated notches on opposite edges of the wire. Using focused magneto-optical Kerr effect measurements of field-driven magnetization reversal we show that several different metastable remanent magnetization states can be formed reproducibly, and that the application of a component of magnetic field transverse to the wire axis maintains the chirality of DW as it interacts with both notches and overcomes the problems of chirality loss due to Walker breakdown.
Privacy-Preserved Search in mCL-PKE Based Secure Data Sharing over Public Clouds and Credential Trust Management through SMTP Communication

: With the fast prominence of cloud computing architecture, public key cryptography exhibit certificate revocation problem and in the case of identity based encryption there exist a key escrow problem. Certificateless public key cryptography schemes now available are not properly sufficient because paring operation needs high amount of computational resources or they are vulnerable to partial decryption attacks. Sensitive data must be encrypted before sharing data over public cloud to maintain data confidentiality which make traditional data utilization invalid based on keyword search of plaintext values. In order to resolve these problem, we proposing an improved Mediated certificateless public key encryption (mCL-PKE) scheme that does not use any pairing operations and solve the problem of sharing sensitive information in public clouds, also implement privacy-preserving searching over encrypted data with set of strict privacy axioms. On that public key encryption credential and key that used for encryption and decryption share through secure SMTP communication for maintaining trust management. In our system, the data owner needs to encode the same information encryption key different times, once for every client, utilizing the clients' open keys. To address this deficiency, we present an augmentation of the fundamental mCL-PKE plan. On the retrieval process, the cloud partially decrypts the encrypted data for the users and send the intermediate decryption keys to user by using secure SMTP communication. Our experiments on the real-world cloud data shows that our schemes are efficient for privacy-preserved search and trust management with mCL-PKE based secure storage also its solve the key escrow problem.