Miracle-dz/UniFAR-FTUs huggingface dataset:
Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes

Homologous flavoproteins from the photolyase (PHR)/cryptochrome (CRY) family use the FAD cofactor in PHRs to catalyze DNA repair and in CRYs to tune the circadian clock and control development. To help address how PHR/CRY members achieve these diverse functions, we determined the crystallographic structure of Arabidopsis thaliana (6-4) PHR (UVR3), which is strikingly (>65%) similar in sequence to human circadian clock CRYs. The structure reveals a substrate-binding cavity specific for the UV-induced DNA lesion, (6-4) photoproduct, and cofactor binding sites different from those of bacterial PHRs and consistent with distinct mechanisms for activities and regulation. Mutational analyses were combined with this prototypic structure for the (6-4) PHR/clock CRY cluster to identify structural and functional motifs: phosphate-binding and Pro-Lys-Leu protrusion motifs constricting access to the substrate-binding cavity above FAD, sulfur loop near the external end of the Trp electron-transfer pathway, and previously undefined C-terminal helix. Our results provide a detailed, unified framework for investigations of (6-4) PHRs and the mammalian CRYs. Conservation of key residues and motifs controlling FAD access and activities suggests that regulation of FAD redox properties and radical stability is essential not only for (6-4) photoproduct DNA repair, but also for circadian clock-regulating CRY functions. The structural and functional results reported here elucidate archetypal relationships within this flavoprotein family and suggest how PHRs and CRYs use local residue and cofactor tuning, rather than larger structural modifications, to achieve their diverse functions encompassing DNA repair, plant growth and development, and circadian clock regulation.
A 1-V 11.6-dBm IIP3 up-conversion mixer for UWB wireless system

This paper proposes an up-conversion mixer designed and implemented in 0.18-µm CMOS process for UWB wireless system. The linearity of the mixer is enhanced by improving the double-balance Gilbert mixer structure to abate the second harmonic distortion. Current-reused bleeding technique is used to reduce the power of the mixer. The mixer demonstrates better than 11.6-dBm IIP3 and 6.5-dB conversion gain. The total power consumption is 8.14-mW at 1 -V power supply.
Q Fever

SUMMARY Q fever is a zoonosis with a worldwide distribution with the exception of New Zealand. The disease is caused by Coxiella burnetii, a strictly intracellular, gram-negative bacterium. Many species of mammals, birds, and ticks are reservoirs of C. burnetii in nature. C. burnetii infection is most often latent in animals, with persistent shedding of bacteria into the environment. However, in females intermittent high-level shedding occurs at the time of parturition, with millions of bacteria being released per gram of placenta. Humans are usually infected by contaminated aerosols from domestic animals, particularly after contact with parturient females and their birth products. Although often asymptomatic, Q fever may manifest in humans as an acute disease (mainly as a self-limited febrile illness, pneumonia, or hepatitis) or as a chronic disease (mainly endocarditis), especially in patients with previous valvulopathy and to a lesser extent in immunocompromised hosts and in pregnant women. Specific diagnosis of Q fever remains based upon serology. Immunoglobulin M (IgM) and IgG antiphase II antibodies are detected 2 to 3 weeks after infection with C. burnetii, whereas the presence of IgG antiphase I C. burnetii antibodies at titers of ≥1:800 by microimmunofluorescence is indicative of chronic Q fever. The tetracyclines are still considered the mainstay of antibiotic therapy of acute Q fever, whereas antibiotic combinations administered over prolonged periods are necessary to prevent relapses in Q fever endocarditis patients. Although the protective role of Q fever vaccination with whole-cell extracts has been established, the population which should be primarily vaccinated remains to be clearly identified. Vaccination should probably be considered in the population at high risk for Q fever endocarditis.
Evaluating the impact of electronic data interchange on the ingredient supply chain of a food processing company

A model of an electronic data interchange (EDI) enabled ingredient supply chain for a food processing company was developed, the model was simulated and its performance was compared with a simulation model of the current ingredient supply chain process of a US food processing company. The simulation results indicated that an EDI enabled system, which removed many of the time delays associated with the current process, significantly reduced swings in raw materials inventory and allowed significant reductions in raw materials safety stock without increasing the risk of production delays due to out‐of‐stock ingredients.
The Role of Corporate Social Responsibility (CSR) in the New Economy

The idea of corporate social responsibility has come to be accepted as one of the major components of business growth and sustainability. The success in the new economy comes with various challenges. Those challenges require business and their managers to think beyond traditional way of looking for short-term goals. It requires business and the people inside these behemoths to embrace a much broader perspective that is also inclusive of stakeholders. The nature of society we are living in has changed. The nature of governance has equally changed since people are now enjoying more freedom within each societal democratic tenet. This freedom has found its way in the business and into the factories. The performance of the new economy is therefore pegged on the three pillars namely; economic, environment, and social. Additionally, issues concerning human rights at the work place, child labor are also considered.
A manufacturer becoming service provider – challenges and a paradox

Purpose – To provide a perspective on the nature of service infusion in manufacturing companies based on a case analysis in the context of a maintenance management solution for industrial production equipment.Design/methodology/approach – The paper first discusses how manufacturers becoming service providers is treated in the literature. Next, a qualitative single‐case study is reported, in which a troublesome business concept was surveyed through 35 thematic focus group interviews. The analysis revealed a set of challenges that were compared to arrive at a conclusion, the paradox.Findings – The findings suggest that many challenges stemmed from the manufacturing‐oriented way of doing business. This further indicates that the common implicit view, that manufacturers can shift to service provision steadily, by adding service offerings to their total offering one by one, may actually be hazardous.Research limitations/implications – The limitations are based on the methodology. First, the case study focuses .
Effect of IFRS on the Emerging African Capital Markets

This study is motivated by the growing momentum of African countries adopting International Financial Reporting Standards (IFRS) by listed, cross-listed and even some unlisted companies. The study empirically examines whether IFRS adoption has impacted investor returns, the decline in discretionary earnings management and the changes in value relevance of accounting information. We find significantly higher informativeness of earnings per share (EPS) under IFRS for investor returns compared to EPS under local Generally Accepted Accounting Principles (GAAP) after controlling for confounding factors. This provides evidence for the value relevance of IFRS adoption and significantly lower earnings management by firms using IFRS compared to firms using local GAAPs.
JAPANESE FIRM RESPONSE TO CHANGING REGULATION: A DYNAMIC STRATEGIC GROUP ANALYSIS

Sabine B. Reddy California State Universi! J l.Dng Beach Devanathan Sudharshan Universi! J of Illinois at Urbana-Champaign Thomas Roehl Western Washington Universi! J Firms must repeated! J respond to changes in the regulatory environment. Rather than focusing on! J on the response of the industry as a whole, we investigate the variation in response at the firm level. We postulate and find that the firm level response will be contingent on the resource base of the firm and the firms degree of isomorphism to past regulatory and competitive conditions. Firms that are most isomorphic appear less able to a4fust strategicallY to drastic environmental shifts. Using cfynamic strategic group methodology, we demonstrate this response variation in a sample of Japanese pharmaceutical firms. Kry Wordr: Japan, pharmaceutical industry, government regulation, globalization, strategic groups, competitiveness
Exploring ERP Adoption Cost Factors

Due to their limited resources, budgets and their high sensitivity to costs, when Small and Medium Enterprises (SMEs) take the first step into implementing an Enterprise Resource Planning (ERP) system, they need to think about many things, foremost the cost of adoption. Literature suggests that most ERP implementations fail due to inaccurate and optimistic budget and schedule estimations, as well as, anticipating indirect costs beforehand is problematic. With the deficiency of a clear model of cost factors for ERP adoptions, ERP adoptions face high risks of failure. Failures could be caused by several factors, but the scope of this research is focused on identifying, exploring, and validating a comprehensive list of ERP adoption cost factors. This could aid SMEs in visualizing the different expected costs, and would consequently assist in better future cost management and estimations. There has been plenty of research in ERP; however, a clear gap in ERP cost identification, management, and estimation exists. This paper focuses on identifying direct and indirect cost factors that influence total costs in the ERP adoption process. The paper presents a cost list that has been developed through literature and an ERP expert panel. Furthermore, this study validates the costs list through interviews with different stakeholders within ERP adoption projects in Egypt.
The Value of Preoperative CA 125 Levels in Prediction of Myometrial Invasion in Patients with Early-stage Endometrioid- type Endometrial Cancer.

AIM To evaluate the relationship between pre-operative CA-125 levels and myometrial invasion in patients with early-stage endometrioid-type endometrial cancer. MATERIALS AND METHODS Two-hundred and sixty patients were diagnosed with endometrial cancer between January 2007 and December 2012. Of these, 136 patients with stage 1 endometrioid histologic-type and documented pre-operative serum CA-125 levels were included in the study. Age, preoperative CA-125 level, histologic grade, surgical grade, and presence of deep myometrial invasion were recorded. Additionally, 16, 20, and 35 IU/ml cutoff values were used and compared to evaluate the relationship between pre-operative CA-125 levels and myometrial invasion. RESULTS The average serum CA-125 level was 35.4±36.7 in patients with deep myometrial invasion, and 21.5±35.8 in cases without deep myometrial invasion. The relationship between the presence of deep myometrial invasion and CA-125 cut-off values (16, 20, 35 IU/ml) was statistically significant, although the correlation was weak (p<0.05). When the relationship between 16, 20 and 35 IU/ml CA-125 cut-off values and the presence of deep myometrial invasion was studied, specifity and sensitivity values were identified as: 0.60-0.68 for 16 IU/ml; 0.73-0.48 for 20 IU/ml; and 0.89-0.33 for 35 IU/ml. The sensitivity of 16 IU/ml cut-off value was higher when compared to other values. CONCLUSIONS This study demonstrates that preoperative serum CA-125 values maybe used as a predictive test in patients with early stage endometrioid-type endometrium cancer, and as a prognostic factor alone. Further studies should be conducted to identify different CA-125 cut-off values in patients with low risk endometrial cancer.
Policy Lessons from Financing Innovative Firms

There has been increasing global concern from policy makers over the lack of access to finance for young innovative firms. As a result, governments in many OECD countries have sought to address the financing gap and perceived market failures by supporting the seed and early stage market. This paper seeks to summarise the lessons learned in seed and early stage finance based on OECD work focused on policies related to financing high growth firms, including angel investment and venture capital. Growth in seed and early stage finance policies highlights the role that financial development and other policies play in firm dynamics and job creation.
Global supplier selection strategies and implications for supplier performance: Turkish suppliers’ perception

In today's global competitive environment, supplier evaluation and selection strategies are not only important for buyer performance and competitiveness, but also for supplier performance and capabilities. This study from the suppliers’ perception examines (i) the structure of supply relationships between Turkish automotive parts and components manufacturers and their global buyers, (ii) global buyers’ supplier evaluation and selection strategies, and (iii) the impact of global buyers’ supplier evaluation and selection strategies on the supplier performance in the long-term. Data from automotive parts and components suppliers in Turkey were used to test the hypotheses through multiple regression analysis. The findings of this study reveal that automotive parts and components suppliers can be either in tier-type relationhips with their global buyers or they can be out of the tier hieararchy. In a tier-type relationhip, supplier can be either first-tier supplier for some products/relationships or/and they can be second-tier supplier for other products/relationships. To establish long-term supply relationships on a global base supplier evaluation and selection strategy is based on many decision criteria and impacts on the supplier's operational, technical and financial performance in the long-term. Therefore, there is a positive association between supplier evaluation and selection strategy and supplier performance, which guides and motivates supplier firms to improve their performance and capabilities. From the supplier's perception, quality, delivery, and price along with commitment and trust are the most important dimensions in global supplier selection and establishing long-term supply relationships. Additionally, while in previous studies buyers perceive cost to be an important supplier selection criterion, in this study suppliers perceive price as more important in supplier selection. As a result, this study, revealing the perception of the suppliers, fulfils a gap and suggests several implications.
The Effect of Job Satisfaction on Organisational Commitment among Shift Workers: A Field Study of Ferro-alloy Industries

Job is social reality and social expectation of an employee. It not only provides status to the individual but also binds with the society. An employee who is satisfied with his job would perform his duties well and be committed to his job and organisation. ‘Job satisfaction’ and ‘organisational commitment’ (OC) are two buzzwords among researchers in last couple of decades and associated with the organisational productivity and organisational culture in a variety of occupational settings. The scope of this research is to investigate the relationship between job satisfaction and OC among shift workers in ferro-alloy industries of Odisha, India. A cross-sectional survey was conducted on a convenient sample of 240 (N) in five ferro-alloy industries of Odisha, India. Correlation and regression analysis revealed a number of significant relationships between the two variables. The findings show that there is a significant positive relationship between job satisfaction, affective and normative commitment variables, but there is a negative association between job satisfaction and continuance commitment. It is assumed that there is no similar research conducted on shift workers in ferro-alloy industries in India. Therefore, this study can add new findings that can be used to improve organisational practices for the retention of valuable employees and to improve organisational work culture and productivity.
Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR*

Recent studies show that a member of the interleukin-1 (IL-1)/Toll receptor superfamily, Toll-like receptor 3 (TLR3), recognizes double-stranded RNA (dsRNA). Because of the similarity in their cytoplasmic domains, IL-1/Toll receptors share signaling components that associate with the IL-1 receptor, including IL-1 receptor-associated kinase (IRAK), MyD88, and TRAF6. However, we find that, in response to dsRNA, TLR3 can mediate the activation of both NFκB and mitogen-activated protein (MAP) kinases in IL-1-unresponsive mutant cell lines, including IRAK-deficient I1A and I3A cells, which are defective in a component that is downstream of IL-1R but upstream of IRAK. These results clearly indicate that TLR3 does not simply share the signaling components employed by the IL-1 receptor. Through biochemical analyses we have identified an IRAK-independent TLR3-mediated pathway. Upon binding of dsRNA to TLR3, TRAF6, TAK1, and TAB2 are recruited to the receptor to form a complex, which then translocates to the cytosol where TAK1 is phosphorylated and activated. The dsRNA-dependent protein kinase (PKR) is also detected in this signal-induced TAK1 complex. Kinase inactive mutants of TAK1 (TAK1DN) and PKR (PKRDN) inhibit poly(dI·dC)-induced TLR3-mediated NFκB activation, suggesting that both of these kinases play important roles in this pathway.
Leveraging the co-evolution of offline and online video games: an empirical study

Abstract Considerable research has been carried out on online shopping and the implications of this purchasing format for consumers and retailers. Most of these studies have focused on consumer attitudes towards online shopping, and how these can be useful predictors of online shopping adoption. Notwithstanding these insights from adoption theory, existing research has yet to distil the most effective means of understanding consumers’ attitudes towards online video game purchases. Based on a qualitative study, our study contributes to literature on adoption theory by presenting some explanations involving online video games purchases by identifying salient perceptions of online and offline motivations and advances ideas on the facilitating role of incentives in making purchase decisions.
Research notes and communications. Some connections between corporate‐level planning and diversity

Two accepted concepts of management literature are (a) increasing diversification as companies progress through ‘stages of growth’, and (b) the responsibility of the corporate level for diversification‐type planning. The thrust of this research note is to provide an empirical test of these independently developed concepts; that is, a test that focuses on the relationship between corporate‐level planning and diversity.
Improving value chain flexibility and adaptability in build-to-order environments

Purpose – Given volatile markets, the ability to quickly act is fundamental for companies – in regard to the internal production and to external supply flows in the value network. Related flexibility and adaptability concepts are vague and contradictory. Managerial methods either imply a generic application level or a narrow focus. Thus, the purpose of this paper is to develop a three-step approach to facilitate a well-directed flexibility and adaptability design within a build-to-order context: context-specific operationalization, thorough segmentation using advanced logistic criteria and purposeful deduction of improvement means. Design/methodology/approach – Based on a thorough literature review, a procedural approach is developed and applied within two rigorously conducted company-cases. A triangulation setting is used within the empirical analysis. Findings – A company's capability to act appropriately, quickly and economically in the face of volatility can be remarkably advanced through context-spec.
LFSR identification using Groebner bases

Given the output of an unknown linear feedback shift register (LFSR), the Berlekamp-Massey algorithm can be used to recover the characteristic polynomial of the LFSR. We propose a method to recover the characteristic polynomial and initial state of an LFSR from a noisy version of its output sequence using Groebner bases.
THE EFFECT OF COVERGENCE TO IFRS ON THE VALUE RELEVANCE OF ACCOUNTING NUMBERS: THE CASE OF MALAYSIA AND SINGAPORE

The movement for the convergence of accounting standards to the International Financial Reporting Standards is driven partly by the globalization of the world’s market and partly by the need for a more comparable and high quality financial reports. One of the advantages for convergence of accounting standards is that it would lower the cost of processing information needed for investment purposes, thereby increasing the efficiency with which the stock market incorporates the accounting information in the stock price. When accounting information affects stock price, they are said to be value relevant. This study aims to determine empirically the effect of the convergence of the local accounting standards to IFRS on the value relevance of book value and earnings in Singapore and Malaysia. Data on book values and equity were collected for 220 Malaysian Main Board companies over the years 2005 and 2006 and 144 Singaporean public listed companies for years 2004 and 2005 from Thompson One Banker database. Using a multiple regression model, it was found that convergence to IFRS seemed to have a significant impact on the value relevance of accounting numbers in Malaysia but the impact is not significant in Singapore.
Aspiration: Cause and Implications

The purpose of this investigation was to determine the overall prevalence of aspiration in dysphagic individuals referred for a modified barium swallow and the underlying anatomic and/or physiologic causes. A total of 166 patients were seen during a 1-month period at 5 participating institutions. Aspiration was detected in 51.2% of the patients. The most common causes were decreased laryngeal elevation and delayed triggering of the pharyngeal motor response. A history of aspiration pneumonia was significantly associated with the presence of aspiration on modified barium swallow study. The presence of a protective cough was present in only 53% of patients who aspirated, reinforcing the need for appropriate radiologic assessment in patients with suspected dysphagia.
Team leadership models: modelling multicultural team success

Multicultural teams are increasingly the modus operandi of multinational organizations and are often seen as the ‘glue’ in these dispersed enterprises. The wealth of multicultural team research hitherto provides little guidance as to the choice of leadership models. The literature on team leadership, in turn, predominantly focuses on single-culture contexts and therefore is void of the complexity posed by multicultural team composition. By examining multicultural team composition in terms of ‘faultlines’ and status cue expectations, we formulate propositions predicting which team leadership model (individual, shared or rotated) will enhance performance.