Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigating the effect of extended high-frequency hearing loss on duration pattern sequence test

Background and Aim: Temporal processing is affected in people exposed to occupational noi­se. The primary goal of this study was to eva­luate the temporal processing of people exposed to occupational noise of more than 85 dB A but have not experienced clinically significant chan­ges at hearing thresholds at conventional frequ­encies. Methods: A comparison between groups were designed using individuals exposed to occupa­tional noise (n = 15 as the case group) and non-exposed individuals (n = 16 as the control gro­up). Two groups were age-matched (p < 0.05). The extended high-frequency audiometric thre­sholds and temporal processing system were evaluated through a duration pattern sequence test. Finally, the correlation between the exten­ded high-frequency hearing thresholds and the duration pattern test scores was investigated. Results: The case group had significantly high­er hearing thresholds than the control group at 14, 15, and 16 kHz (p < 0.05). Although in other frequencies, the mean hearing thresholds in the case group was higher than the control group, the difference was not significant. Also, the case group had significantly lower duration pattern sequence scores than the control group in the right (p = 0.02) and the left ears (p = 0.03). There was no correlation between extended high-frequency hearing thresholds and duration pattern sequence test scores. Conclusion: In people exposed to occupational noise, both extended high-frequency thresholds and temporal processing in lower frequency ran­ges (with normal hearing thresholds) are inter­rupted.
Simultaneous (Near Simultaneous) bilateral basal ganglial bleed – A rarity

Intra-cerebral hemorrhages are a known cause of significant mortality and morbidity, among all the different forms of stroke. Primary multiple simultaneous intra-cerebral hemorrhages (MSICHs) are not common and has been reported in association with other diseases. There are only around 105 cases reported. The diseases most commonly associated are thrombophilia and hematologic disorders, vasculitis, neoplasms, arterio-venous malformation, anticoagulant therapy, illicit drug use, or multiple infarction with hemorrhagic transformation. Though the outcome is not much different, probably marginally worse compared to a regular stroke. Herein we describe a middle age male with hypertension who was referred to us with basal ganglial bleed.
The Role of Physiatrist in the Diabetes Healthcare Team

The physiatrist is an important member of the diabetes healthcare team. His/her primary role is to provide physical activity counselling for the diabetics after thorough evaluation. Exercise is a primary component of diabetes management together with diet plan and antidiabetic drugs. The physiatrist, with his/her background knowledge in exercise physiology, is the most appropriate person for this job. Regular exercise has been shown to improve blood glucose control, reduce cardiovascular risk factors, contribute to weight loss and improve well being. Furthermore, regular exercise may prevent type 2 diabetes in high risk individuals. Thus physical activity plays a pivotal role in health promotion and diabetes control. People with diabetes should be advised to perform at least 150 minutes per week of moderate intensity aerobic physical activity using ‘FITT Principle’. In the absence of contra-indications, people with type 2 diabetes should be encouraged to perform resistance training three times per week. DeLorme resistance exercise improves power, strength, endurance and burns more calories. Cross training is the term used to describe the use of a variety of activities during exercise. Interval training is the variation of intensity during one or more aerobic activities. Circuit training is the combination of aerobic exercise and weight training (anaerobic exercise). Before recommending a programme of physical activity, the physiatrist should assess diabetics for coronary artery disease and other complications of diabetes.
Ultrasound-Guided Lumbar Transforaminal Epidural Injections; A Single Center Fluoroscopic Validation Study.

Objective To investigate the success rate (technical precision) of ultrasound-guided lumbar transforaminal epidural steroid injection, which was validated by conventional fluoroscopic technique. Methods A total of 20 patients with unilateral single-level lumbar foraminal disc protrusion causing radiculopathy were enrolled. Using transforming route, the needle location was determined by an axial (transvers) view of the ultrasound with fluoroscopic confirmation. We determined the needle placement accuracy of ultrasound- guided lumbar transforaminal injections approach. Results The accuracy of ultrasound-guided interventions was 90% as confirmed by fluoroscopy. There were 2 failed cases at the L4-L5 level in the US-guided. The success rate in L5-S1 level was 100%, in L4-L5 level was 80% and in L3-L4 level was 100%. No complications were noted. Conclusion Ultrasound-guided lumbar transforaminal epidural injections are accurate and feasible in clinical setting with an accuracy of 90% and no complications.
Predictors of poor outcome in embolic stroke of undetermined source

Objectives: To identify the clinical predictors of death or disability at discharge. Methods: We retrospectively reviewed all ischemic stroke patients admitted to the stroke unit of King Abdulaziz Medical City, Riyadh, Saudi Arabia, from February 2016 - July 2018. We applied the Cryptogenic Stroke/ESUS International Working Group Embolic stroke of undetermined source (ESUS) criteria. We compared patients with poor outcomes (death or modified Rankin Scale [mRS] score >2) to those with favorable outcomes. Multivariate logistic regression was used to identify predictors of poor outcome. The regression model included age >60 years, gender, body mass index >25 kg/m2, smoking history, comorbidities, previous ischemic/transient ischemic attack, pre-stroke mRS score >1, National Institutes of Health Stroke Scale (NIHSS) score at admission >5, pre-stroke antiplatelet use, and thrombolysis treatment. Results: Out of 147 patients who met the ESUS criteria, 28.8% had poor outcomes. Predictors of poor outcome were NIHSS score >5 (odds ratio [OR] 11.1, 95% confidence interval [CI] 4.4–28.2), pre-stroke mRS score >1 (OR 3.7, 95% CI 1.14–11.59), and age >60 years (OR 2.4, 95% CI 1.14–5.22). Conclusion: A significant proportion of ESUS patients were dead or disabled at discharge. Poor outcome was more in older patients with pre-stroke functional disability and moderate to severe stroke.
ANALYSIS OF RISK FACTORS IN PATIENTS WHO HAVE UNDERGONE CORONARY ARTERY BYPASS GRAFTING SURGERY AND VALVE REPLACEMENT SURGERY

Aims: The aim of the study is to investigate differences in usual cardiovascular risk factors’ and comorbidities between the patients who had undergone coronary artery bypass grafting surgery and valve replacement surgery at Cardiovascular Surgery Department of Trakya University School of Medicine. Methods: In this study, patients who had coronary artery bypass grafting surgery and valve replacement surgery at Cardiovascular Surgery Department of Trakya University School of Medicine between 01.01. 2018 and 31.12. 2018 were analyzed retrospectively. All data regarding the type of cardiovascular operation, habits of smoking, alcohol consumption, family history, chronic diseases and laboratory findings were analyzed using R version 3.5. 0. Results: The total number of patients in the study was 130. There were 106 patients who had coronary bypass grafting surgery, 90 (95.4%) of them were male and 16 (4.6%) of them were female. The number of the patients who had valve replacement surgery was 24 where 15 (62.5%) of them were female and 9 (37.5%) were male. Differences in patients’ high-density lipoprotein levels, fasting blood glucose levels along with gender, habits of smoking, diabetes mellitus status and alcohol consumption between coronary artery bypass grafting surgery and valve replacement surgery groups were found statistically significant. Conclusion: Risk factors for cardiovascular disease are very dynamic and multifactorial. In our analysis, there was a significant difference between risk factors for coronary artery bypass and valve replacement surgeries including high-density lipoprotein levels, fasting blood glucose levels, diabetes mellitus, gender and smoking status. The variability may alter according to the living standards, culture, educational status among patients. Keywords: Coronary disease, coronary artery, surgery, risk factors
BatchQueue : file producteur / consommateur optimisée pour les multi-cœurs

Les applications sequentielles peuvent tirer partie des systemes multi-cœurs en utilisant le parallelisme pipeline pour accroitre leur performance. Dans un tel schema de parallelisme, l'acceleration possible est limitee par le surcout du a la communication cœur a cœur. Ce papier presente l'algorithme BatchQueue, un systeme de communication rapide concu pour optimiser l'utilisation du cache materiel, notamment au regard du pre-chargement. BatchQueue propose des performances ameliorees d'un facteur 2 : il est capable d'envoyer un mot de donnees en 3,5 nanosecondes sur un systeme 64 bits, representant un debit de 2 Gio/s.
Impact of Emergency Department Prescriber Type on the Rate of U.S. Opioid Prescriptions

Impact of Emergency Department Prescriber Type on the Rate of U.S. Opioid Prescriptions by Edward Worlanyo Agbevey MPH, Eastern Virginia Medical School, 2012 BS, University of Education, Kumasi Ghana, 2005 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Health Services Walden University August 2019 Abstract Many drug overdoses in the United States are from prescription drugs, most of which are classified as opioid pain relievers (OPRs) and commonly prescribed in emergency departments (EDs) to treat pain. OPR abuse and addiction is a major public health issue. Researchers have identified the role of various patient characteristics (race, gender, demographics, etc.) in the variation in OPR prescription rates, but the contribution ofMany drug overdoses in the United States are from prescription drugs, most of which are classified as opioid pain relievers (OPRs) and commonly prescribed in emergency departments (EDs) to treat pain. OPR abuse and addiction is a major public health issue. Researchers have identified the role of various patient characteristics (race, gender, demographics, etc.) in the variation in OPR prescription rates, but the contribution of provider-type differences to that variation has not been exposed. The purpose of this study was to evaluate the strength of the association between provider type and the likelihood of an opioid prescription by ED providers using national-level population data. Drawing from symbolic interaction theory, which served as the study’s theoretical framework, it was postulated that the training and background of ED providers influence their interaction and OPR prescription decisions. The National Hospital Ambulatory Medical Care Survey 2015 data were used to evaluate the association between provider type and the likelihood of an OPR prescription, and the possible confounding effect of patients’ race and payment type. Logistic regression analysis showed that attending physicians, consulting physicians, and physician assistants were more likely (OR = 1.491, 1.318, and 1.315, respectively) to prescribe an OPR in the ED, while controlling for age and pain level. Both race and payment type had predictive relationships with the outcome variable, but only payment type interacted significantly with provider type. These findings can serve as the basis for evidence-based training, procedure guidelines, and policy development, as well as inform patient-provider interactions, potentially leading to safer, more effective pain management encounters in the ED. Impact of Emergency Department Prescriber Type on the Rate of U.S. Opioid Prescriptions by Edward Worlanyo Agbevey MPH, Eastern Virginia Medical School, 2012 BS, University of Education, Kumasi Ghana, 2005 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy
CRISPR screens and the best cancer drug targets: picking the needle out of the haystack

In the past two decades, the clinical management of cancer patients, mostly based on the use of surgery, chemotherapy and radiotherapy, has been revolutionized by the development of precision medicine and new immunotherapy approaches, two new pillars in cancer therapeutics. The ways to treat cancer have enormously increased providing more tailored approaches to cancer patients, who can be offered a wider range of therapeutic options. Despite such progress, however, the huge heterogeneity of tumors and their ability to develop resistance to therapies make cancer a moving target. Cancer-specific dependencies and the best drug targets need to be identified to increase even more the arsenal of weapons that can be used at different stages of treatment in a sequential manner to defeat the disease or make it become chronic.
Epidemiology of Intestinal Polyparasitism among Schoolchildren In Sohag, Egypt

Department of Medical Parasitology, Faculty of Medicine, Sohag University, Egypt. Correspondence to DrNoha S. Ahmed, Department of Medical Parasitology, Faculty of Medicine, Sohag University, Sohag 2630, Egypt E-mail: nohasammer@yahoo.com Abstract Introduction: Intestinal parasitic infections (IPI) are still public health problems in many communities, particularly among children in developing countries.This crosssectional study aimed to investigate the current prevalence and risk factors associated with intestinal polyparasitism (the concurrent infection with multiple intestinal parasite species) among schoolchildren in Sohag governorate, Egypt. Methodology / Principal findings: Fecal samples were collected from 200 schoolchildren (51.5% boys and 48.5% girls), preserved and examined by using formalin-ethyl acetate concentration technique and modified Kinyoun acid fast stain. Demographic information was collected by using a standardized questionnaire. Overall, 63.5% of the children were found to be positive for at least one parasite species. Of these, 23.5% were polyparasitized. The overall prevalence of Cryptosporidium, Giardia duodenalis, Entamebahistolytica/ dispar, Blastocystisinfections were 34%, 14.5% and 13%, respectively. Univariate and multivariable logistic regression models showed that none of the age, gender, residence or family size were risk factors for polyparasitism. Conclusions/Significance: Intestinal polyparasitism is prevalent among children in Sohag, Egypt. Hence, effective and sustainable control measures, including schoolbased periodic chemotherapy, providing adequate health education focused on good personal hygiene practices and proper sanitation, as well as safe drinking water supply should be implemented to reduce the prevalence and consequences of these infections in this population.
Total Small Vessel Disease Burden Predicts Functional Outcome in Patients With Acute Ischemic Stroke

Background: Cerebral small vessel disease (SVD) is generally considered as a cause of stroke, disability, gait disturbances, vascular cognitive impairment, and dementia. The aim of this study was to investigate whether the total SVD burden can be used to predict functional outcome in patients with acute ischemic stroke. Methods: From April 2017 to January 2018, consecutive patients with acute ischemic stroke who underwent baseline MRI scan were evaluated. The functional outcome was assessed using the modified Rankin Scale (mRS) at 90 days and defined as i) excellent outcome (mRS ≤ 1) and ii) good outcome (mRS ≤ 2). Brain MRI was performed and assessed for lacunes, white matter hyperintensities (WMH), and enlarged perivascular spaces (EPVS). The total SVD burden was calculated based on lacunes, WMH, and EPVS and then summed up to generate an ordinal “total SVD burden” (range 0–3). Bivariate logistic regression models were used to identify the association between SVD and functional outcome. Results: A total of 416 patients were included in the final analysis; 44.0, 33.4, 19.2, and 3.4% of the patients had 0, 1, 2, and 3 features of SVD, respectively. In regard to individual SVD feature, lacunes (OR: 0.48, 95% CI: 0.32–0.71; OR: 0.49, 95% CI: 0.31–0.77) and WMH (OR: 0.53, 95% CI: 0.34–0.82; OR: 0.53, 95% CI: 0.33–0.85) were negatively associated with excellent outcome and good outcome. As to the total burden of SVD, three SVD features had strongest negative associations with functional outcomes (excellent outcome, OR: 0.13, 95% CI: 0.03–0.48; good outcome, OR: 0.18, 95% CI: 0.06–0.54). After adjustment for potential confounders, a high SVD burden (3 features, OR: 0.07, 95% CI: 0.01–0.41) and the score of total SVD burden (OR: 0.64, 95% CI: 0.44–0.93) remained negatively associated with excellent outcome. Conclusion: Total SVD burden negatively associated with functional outcome at 3 months in patients with acute ischemic stroke and is superior to individual SVD feature in prediction of functional outcome. MRI-based assessment of total SVD burden is highly valuable in clinical management of stroke victims and could help guide the allocation of resources to improve outcome.
Cloud Computing: A model Construct of Real-Time Monitoring for Big Dataset Analytics Using Apache Spark

The volume of data being collected, analyzed, and stored has exploded in recent years, in particular in relation to the activity on the cloud computing. While large-scale data processing, analysis, storage, and platform model such as cloud computing were previously and currently are increasingly. Today, the major challenge is it address how to monitor and control these massive amounts of data and perform analysis in real-time at scale. The traditional methods and model systems are unable to cope with these quantities of data in real-time. Here we present a new methodology for constructing a model for optimizing the performance of real-time monitoring of big datasets, which includes a machine learning algorithms and Apache Spark Streaming to accomplish fine-grained fault diagnosis and repair of big dataset. As a case study, we use the failure of Virtual Machines (VMs) to start-up. The methodology proposition ensures that the most sensible action is carried out during the procedure of fine-grained monitoring and generates the highest efficacy and cost-saving fault repair through three construction control steps: (I) data collection; (II) analysis engine and (III) decision engine. We found that running this novel methodology can save a considerate amount of time compared to the Hadoop model, without sacrificing the classification accuracy or optimization of performance. The accuracy of the proposed method (92.13%) is an improvement on traditional approaches.
Improved Superelastic NiTi wire for the Treatment of Adult Skeletal Class III Malocclusion in a Surgery-first Case

A 19-year-old female came to our department with the chief complaint of facial asymmetry. Clinical examination showed skeletal class III relationship with mandibular prognathism, large reverse overjet, lower right mild crowding, and left hemimandibular elongation. After a thorough discussion with the patient, she accepted the proposal of orthognathic surgery and mandibular setback by bilateral sagittal split osteotomy (BSSRO), and therefore, tooth extraction was performed for 18, 28, 38, and 48 before the surgery. An improved superelastic Ti-Ni alloy wire (ISW wire), developed by Tokyo Medical and Dental University, was then used to facilitate the correction of lower crowding. Involved mechanism included intermaxillary elastics for a better interdigitation and jaw relationships. Adequate overbite and overjet were achieved after treatment completion.
Selective Three-phase Current Reference Generation Using Multi-resonant Method For Shunt Active Power Filter

This paper proposes the application of an accurate, fast and stable method to be used by the control systems in the selective compensation of harmonic currents in three phase systems susceptible to frequency changes and phase jumps. This application is based on a MSOGI-FLL (Multiple Second Order Generalized Integrators Frequency Locked Loop) method, which is composed of multiple double adaptive filters called Dual Second Order Generalized Integrators (DSOGI) coupled to the frequency detector entitled Frequency Locked Loop (FLL) which keeps the set synchronized, even in abnormal situations.
Greedy-SG un procedimiento aplicado al problema de clustering

El problema de clustering consiste en ordenar objetos (personas, cosas, animales, plantas, variables, etc.) en grupos (conglomerados o clústeres) de forma que el grado de asociación o similitud entre los miembros del mismo grupo sea más fuerte y bastante diferente a los que se encuentran en otros grupos. Para resolver el problema tenemos el K-Means, el cual es un algoritmo sencillo y eficiente que procesa los patrones secuencialmente; sin embargo, está sesgado por el orden de presentación de los patrones, tiene alta dependencia de la elección de los centros iniciales y muestra la convergencia a óptimos locales. El presente trabajo propone una solución denominada algoritmo GreedySG, conformado por dos procesos. El primero consta de tres fases: Inicialización, Construcción y Búsqueda Local, y el segundo, de Selección Grupal (SG) es una propuesta de evaluación de los grupos que pasarán a formar parte de la solución final.
Type 1 cluster of differentiation 36 deficiency-related cardiomyopathy accelerates heart failure with co-existing mitral valve prolapse: a case report

Abstract Background Free fatty acid is a major energy source in the healthy heart and cluster of differentiation 36 (CD36) partially regulates the rate of myocardial fatty acid uptake. Here, we report a case of CD36 deficiency-related cardiomyopathy with a unique pathophysiology. Heart failure was accelerated by co-existing mitral valve prolapse (MVP) without a distinct phenotype of hypertrophic or dilated cardiomyopathy. Case summary A middle-aged man was aware of dyspnoea and hospitalized for heart failure with MVP. Cluster of differentiation 36 deficiency was found based on the absence of myocardial 123l-15-(p-iodophenyl)-3-(R,S)-methyl pentadecanoic acid (BMIPP) uptake by myocardial scintigraphy. Type I CD36 deficiency was further diagnosed by the lack of CD36 in both platelets and monocytes by flow cytometry. Left ventricular muscle was obtained intraoperatively, and a histological examination reflected compensative hypertrophy of cardiomyocytes with myofibrillar loss and reactive fibrosis. The microvascular structure around the cardiomyocytes was highlighted by immunohistochemical staining for CD31, while CD36 expression was absent. He had an operation of mitral valve replacement and improved heart failure. Discussion Cluster of differentiation 36 deficiency potentially mediates various pathological conditions in the heart. Incidental CD36 deficiency-related cardiomyopathy may accelerate heart failure in the presence of co-existing heart diseases. BMIPP scintigraphy might be helpful for predicting CD36 deficiency.