Miracle-dz/UniFAR-FTUs huggingface dataset:
The safety of anidulafungin

The echinocandins are a new class of antifungal that have shown promising results in treating a variety of fungal infections. Anidulafungin is the newest approved echinocandin and may have some advantages over existing antifungals. It has activity against a broad range of fungi. It is unique because it undergoes a process of slow chemical degradation rather than being metabolised. Studies evaluating the use of anidulafungin in combination with other commonly used drugs have not demonstrated any significant drug–drug interactions or adverse events. Thus far, anidulafungin appears to have an excellent safety profile with few adverse events. Based on early clinical experience, it appears that anidulafungin will be a valuable and safe asset in the management of serious and difficult-to-treat fungal infections.
Calculations of Frequency Response Functions (FRF) Using Computer Smart Office Software and Nyquist Plot under Gyroscopic Effect Rotation

Regenerated (FRF curves), synthesis of (FRF) curves there are two main requirement in the form of response model, The first being that of regenerating "Theoretical" curve for the frequency response function actually measured and analysis and the second being that of synthesising the other functions which were not measured,(FRF) that isolates the inherent dynamic properties of a mechanical structure. Experimental modal parameters (frequency, damping, and mode shape) are also obtained from a set of (FRF) measurements. The (FRF) describes the input-output relationship between two points on a structure as a function of frequency. Therefore, an (FRF) is actually defined between a single input DOF (point & direction), and a single output (DOF), although the FRF was previously defined as a ratio of the Fourier transforms of an output and input signal. In this paper we detection FRF curve using Nyquist plot under gyroscopic effect in revolving structure using computer smart office software. Keywords - FRF curve; modal test; Nyquist plot; software engineering; gyroscopic effect; smart office.
A Feedforward $10\times$ CMOS Current-Ripple Suppressor for Switching Power Supplies

With the advent of wireless microsensors and other microscale applications, switching supplies fully integrated on chip or into the package are desirable and often necessary. The problem with small inductors is that they exhibit low inductance and larger equivalent series resistance (ESR); in other words, they induce larger ripples in the output and higher conduction power losses. This brief presents and verifies a current-ripple suppression technique in which a discrete 2 × 2 × 1 mm3 4.7-¿H inductor is effectively multiplied by subtracting a replica of the inductor's ac ripple current, allowing only a residual ripple to reach the output. Experimental results from a complementary metal-oxide-semiconductor integrated circuit prototype demonstrate a currentand output-ripple reduction of 10.8 X and 25.8 X, respectively. The ESR power savings in the smaller inductor favorably offset the quiescent power lost in the multiplier (128 mW), outperforming its higher nonmultiplied 47-¿H counterpart at high loads (above 250 mA).
HDL as a contrast agent for medical imaging

Abstract Contrast-enhanced MRI of atherosclerosis can provide valuable additional information on a patient’s disease state. As a result of the interactions of HDL with atherosclerotic plaque and the flexibility of its reconstitution, it is a versatile candidate for the delivery of contrast-generating materials to this pathogenic lesion. We herein discuss the reports of HDL modified with gadolinium to act as an MRI contrast agent for atherosclerosis. Furthermore, HDL has been modified with fluorophores and nanocrystals, allowing it to act as a contrast agent for fluorescent imaging techniques and for computed tomography. Such modified HDL has been found to be macrophage specific, and, therefore, can provide macrophage density information via noninvasive MRI. As such, modified HDL is currently a valuable contrast agent for probing preclinical atherosclerosis. Future developments may allow the application of this particle to further diseases and pathological or physiological processes in both preclinical models as well as in patients.
FunctiOnal capacity and quality OF liFe aMOng eldeRly patients with OR withOut dysphagia aFteR an ischeMic stROke

738 Rev Assoc Med Bras 2010; 56(6): 738-43 *Correspondence: SQS 307 Bloco H Apto 301 – Bairro: Asa Sul Brasília – DF – Brazil CEP: 70354-080 AbstrACt Objective. To analyze the functional capacity and quality of life of elderly people after Ischemic stroke, comparing patients with dysphagia with those free from dysphagia. MétOdOs. This was a cross-sectional study of 60 elderly stroke patients, 30 of whom had dysphagia 30 of whom were free from dysphagia. The Mini-Mental test was used to assess subjects’ cognitive status. The Katz, Lawton, Barthel and SF-36 scales were used. Results. Functional capacity was similar in both groups. According to the SF-36, the subset without dysphagia exhibited more Pain, but better General Health. Functional Capacity, Role-Physical, General Health, Vitality, Social Functioning, Role-Emotional and Mental Health were similar for both subsets. Among the men functional capacity was similar in both subsets, irrespective of the instrument used. Among the women, functional capacity was similar while on the quality of life assessment Vitality scores were higher in the subset without dysphagia. Neither functional capacity nor quality of life were affected by low income. There was also no difference between the two subsets based on having or not having a carer. cOnclusiOns. 1) Functional Capacity was similar in the two subsets. 2) The subset without dysphagia had better General Health.
Skin Necrosis due to Photodynamic Action of Benzoporphyrin Depends on Circulating Rather than Tissue Drug Levels: Implications for Control of Photodynamic Therapy

In an ideal world, photodynamic therapy (PDT) of abnormal tissue would reliably spare the surrounding normal tissue. Normal tissue responses set the limits for light and drug dosimetry. The threshold fluence for necrosis (TFN) was measured in normal skin following intravenous infusion with a photosensitizer, benzoporphyrin derivative monoacid ring A (BPD‐MA) Verteporfin as a function of drug dose (0.25‐2.0 mg/kg), wavelength of irradiation (458 and 690 nm) and time interval (0–5h) between drug administration and irradiation. The BPD‐MA levels were measured in plasma and skin tissue to elucidate the relationship between TFN, drug kinetics and biodistribution. The PDT response of normal skin was highly reproducible. The TFN for 458 and 690 nm wavelengths was nearly identical and the estimated quantum efficiency for skin response was equal at these two wavelengths. Skin phototoxicity, quantified in terms of 1/ TFN, closely correlated with the plasma pharmacokinetics rather than the tissue pharmacokinetics and was quadratically dependent on the plasma drug concentration regardless of the administered drug dose or time interval between drug and light exposure. This study strongly suggests that noninvasive measurements of the circulating drug level at the time of light treatment will be important for setting optimal light dosimetry for PDT with liposomal BPD‐MA, a vascular photosensitizer.
Emotions, Coping, and Psychological Well-Being in Elderly People with Arthritis

Rheumatoid arthritis, the most destructive and crippling of allforms of arthritis, poses a number of stressful demands on individuals. In a sample of elderly women (N = 59) and men (N = 19) with rheumatoid arthritis, the relationship between social economic status, severity of impairment, sex, stress emotions, type of coping strategy, and psychological well-being was explored. Path analysis results indicated that higher social economic status was directly related to greater use of confrontive types of coping strategies. Severity of impairment had a direct, negative influence on psychological well-being, but sex was not an important factor Optimistic coping strategies were used most often and emotive coping strategies the least.
[Effect of veneering technologies on color and translucency of Y2O3 stabilized tetragonal zirconia polycrystals all-ceramic restorations].

OBJECTIVE To compare color parameters and transmittance of Y2O3 stabilized tetragonal zirconia polycrystals (Y-TZP) all-ceramic restorations using different veneering technologies. METHODS Fifteen disc specimens with 10 mm in diameter and (0.50 +/- 0.01) mm in thickness were fabricated of IPS e. max ZirCAD core material, and ZL1 IPS e. max ZirLiner was layered in 0.10 mm thickness. The specimens were divided into three groups randomly (n=5 per group). Group ZP was veneered 0.60 mm by heat-pressing; group ZC was veneered 0.60 mm by layering; group ZPC was veneered 0.30 mm by heat-pressing and then 0.30 mm by layering. Color parameters L*, a*, b* and transmittance of zirconia specimens were measured before and after veneering with ShadeEye NCC dental chromameter and spectrophotometer. Color saturation C* ab and color difference deltaE were calculated in the following formulae: C* ab = [(a*)2 + (b*)2](1/2), deltaE = [(deltaL*)2 + (deltaa*)2 + (deltab*)2](1/2) One-way analysis of variance and Turkey's multiple comparison test were used to analyze data (alpha = 0.05) by SPSS 10.0 statistic software. Color parameters of A2 shade tabs were measured, and color differences between each group and tab were calculated. RESULTS As to ZP,ZPC,ZC groups, the value of a* increased (-1.35 +/- 0.07, -0.64 +/- 0.06, -0.36 +/- 0.05) (P < 0.05), the value of b* decreased (27.01 +/- 0.07, 25.48 +/- 0.11, 23.28 +/- 0.25) (P < 0.05), and the value of C* ab decreased (27.04 +/- 0.08, 25.49 +/- 0.11, 23.28 +/- 0.25) (P < 0.05). L* and transmittance were maximum in ZP group (87.53 +/- 0.48, 1.64 +/- 0.03) and minimum in ZPC group (82.14 +/- 0.18, 1.47 +/- 0.01) (P < 0.05). Compared with standard A2 shade tab, the color difference of ZC group was minimum (delta = 1.04), and the color difference of ZP group was maximum (deltaE = 4.86). CONCLUSIONS Y-TZP all-ceramic restoration veneered by heat-pressing was the most transparent and lightest; while veneered by both heat-pressing and layering, the restoration was worst in translucency and the least light. The color of zirconia all-ceramic restoration veneered by layering was the most similar to standard shade tab, and the color difference was minimum.
SINGLE MUTATIONS SILENCE PGIC2 GENES IN TWO VERY RECENT ALLOTETRAPLOID SPECIES OF CLARKIA

Abstract Our understanding of how polyploidy influences gene evolution is limited by the fact there have been few molecular descriptions of particular genes and their expression in polyploid plants and their diploid progenitors. Here we use evidence from sequencing of genomic DNA and cDNA obtained by reverse transcriptase–polymerase chain reaction and 3′ rapid amplification of cDNA ends to describe PgiC genes and their expression in two allotetraploid species of the wildflower genus Clarkia, C. delicata and C. similis. PgiC encodes the cytosolic isozyme of phosphoglucose isomerase (EC 5.3.1.9) and was duplicated in the ancestral stock of Clarkia, giving rise to paralogous genes PgiC1 and PgiC2. The active form of the PGIC enzyme is a dimer of like subunits. The electrophoretic patterns in the parent species show three bands of activity, representing two homodimers and a heterodimer of intermediate mobility, and are encoded by two genes. The electrophoretic patterns in the tetraploids also show three bands, but the tetraploids were expected to have multiple PGIC isozymes encoded by four genes. Our molecular studies demonstrated that each tetraploid has two PgiC1 and two PgiC2 genes, as predicted. One gene in each of them has been silenced by a single mutation, and a functional protein is no longer produced. In C. similis, PgiC2mod was silenced by a mutation of a single nucleotide in exon 5 that created a stop codon. In C. delicata, a polymorphism exists between a normal allele and a defective allele of PgiC2epi that has a deletion of a splice junction in intron 19 that results in the synthesis of a transcript lacking an entire exon, an example of exon skipping. The three-banded PGIC electrophoretic pattern of both tetraploid species arises because isozymes encoded by two or three of the genes comigrate. A very recent origin for both tetraploids is suggested by the near identity of several of their PgiC genes to their corresponding diploid orthologues and the absence of any acceleration in mutation rates. The problem of assessing genetic redundancy in tetraploids is discussed. Corresponding Editor: D.Baum
A Fast Loss and Temperature Simulation Method for Power Converters, Part I: Electrothermal Modeling and Validation

Simulation of power converters has traditionally been carried out using simplified models to shorten simulation time. This will compromise the accuracy of the results. A proposed fast simulation method for simulating converter losses and device temperatures over long mission profiles (load cycles) is described in this paper. It utilizes accurate physics-based models for the device losses, and is validated with experimentally obtained results.
Beyond Exposure for Posttraumatic Stress Disorder (PTSD) Symptoms

Although cases of posttraumatic stress disorder (PTSD) with comorbid disorders are common, the first generation of PTSD treatment approaches, including exposure and cognitive-behavioral therapy, generally ignore symptoms beyond those specific to PTSD. Optimum PTSD treatment outcome requires more comprehensive strategies, and the development and empirical testing of broader approaches is the focus of the articles that follow in this special issue. After providing some background on PTSD and PTSD treatment, this paper gives an overview of these treatment and prevention papers, which represent second-generation strategies to help trauma-exposed individuals.
A Novel Fractal Monopole Antenna with Wide Bandwidth Enhancement for UWB Applications

─ A novel wideband fractal monopole antenna with a semi-elliptical ground plane is presented. In this letter, by inserting a fractal shape in the conventional circular ring, much wider impedance bandwidth and new resonances are generated. By only increasing the fractal iterations, larger bandwidth is attained. The designed antenna has a compact size of 25×25×1 mm and operates over the frequency band between 2.2 and 17 GHz for VSWR<2. The process of improving the impedance bandwidth and measured results are presented and discussed. Index Terms ─ Fractal, monopole antenna, UltraWideband (UWB).
Resistencia genética de híbridos de papa (Solanum tuberosum L.) al estrés hídrico por sequía

Con el objetivo de seleccionar clones resistentes a sequia en condiciones de invernadero, se evaluaron nueve familias de cruzamientos interespecificos con un total de 563 clones. Las familias fueron sometidas a sequia durante 10 dias en el inicio de tuberizacion (a los 76 dias despues de la siembra). Las variables respuesta fueron la severidad (S), recuperacion (R), grado de postrado (P), volumen de raiz (VR), peso seco de raiz (PSR), longitud de raiz (LR), eficiencia de uso de agua (WUE), peso (PT) y numero de tuberculos (NT). En base a los parametros evaluados fueron seleccionados 19 clones con mayor resistencia a estres hidrico por sequia. La familia 02-208 (YH - blb x phu) mostro el menor S y mayor R con respecto a las demas familias. Hubo alta correlacion de la variable R versus P, VR, LR y WUE. Por otra parte, los componentes de varianza genetica mostraron que los efectos aditivos y dominantes son igualmente importantes en la resistencia al estres hidrico por sequia en la mayoria de las variables evaluadas. Las heredabilidades en sentido amplio para S, R y P (o turgencia) fueron las mas altas (mayor al 80%), esto sugiere que estos caracteres son adecuados para la seleccion de clones con genes de resistencia a estres hidrico por sequia. El progenitor masculino [phu x blb 21] mostro una alta aptitud combinatoria general (ACG) para las variables mencionadas y las cruzas A (blb x phu) x NKD – 164 (stn) y [Chulina 3 (phu)] x (phu x blb21) mostraron las mas alta aptitudes combinatorias especificas (ACE).
Identification of hifD and hifE in the pilus gene cluster of Haemophilus influenzae type b strain Eagan

Haemophilus influenzae produces surface structures called pili that promote adherence to human cells. Three genes encoding the major pilus structural component (pilin), chaperone, and usher proteins (designated hifA, -B, and -C, respectively) have been identified previously. In this study, transposon mutagenesis and DNA sequence analysis identified two open reading frames (ORFs) downstream of, and in the same orientation as, hifC. These genes have been designated hifD and hifE. Both genes have predicted C-terminal amino acid homology to HifA, and mutations in either gene resulted in the loss of morphologic and functional pili, indicating that hifD and hifE encode pilus structural components and are required for pilus expression. Another ORF, identified immediately downstream of hifE, has a predicted amino acid sequence that is 70% identical to an aminopeptidase of Escherichia coli called PepN, and a mutation within this ORF did not alter pilus expression. These data indicate that the pepN homolog is not required for pilus biogenesis and that one end of the pilus gene cluster has been defined.
Cloud computing and its applications

With the significant advances in Information and Communications Technology (ICT) over the last half century, there is an increasingly perceived vision that computing will one day be the 5th utility (after water, electricity, gas, and telephony). This computing utility, like all other four existing utilities, will provide the basic level of computing service that is considered essential to meet the everyday needs of the general community. To deliver this vision, a number of computing paradigms have been proposed, of which the latest one is known as Cloud computing. Hence, in this paper, Cloud computing is defined and the architecture for creating Clouds with market-oriented resource allocation are provided by leveraging technologies such as Virtual Machines (VMs). Also insights on market-based resource management strategies that encompass both customer-driven service management and computational have been provided. Cloud computing customers generally do not own the physical infrastructure, instead avoiding capital expenditure by renting usage from a third-party provider. They consume resources as a service and pay only for resources that they use. Many cloud-computing offerings employ the utility computing model, which is analogous to how traditional utility services (such as electricity) are consumed, while others bill on a subscription basis. Sharing "perishable and intangible" computing power among multiple tenants can improve utilization rates, as servers are not unnecessarily left idle (which can reduce costs significantly while increasing the speed of application development). A side effect of this approach is that overall computer usage rises dramatically, as customers do not have to engineer for peak load limits. Additionally, "increased high-speed bandwidth" makes it possible to receive the same response times from centralized infrastructure at other sites. The risk management to sustain Service Level Agreement (SLA)-oriented resource allocation. In addition, the early thoughts are being revealed on interconnecting Clouds for dynamically creating global Cloud exchanges and markets. Furthermore, the difference between High Performance Computing (HPC) workload and Internet-based services workload are also highlighted.
Heat-shock protein 60 as a tool for novel therapeutic strategies that target the induction of regulatory T cells in human arthritis

In health, immune responses to self are abundantly available, but under strict control of mechanisms of peripheral tolerance. Occasionally the immune system loses control and an autoimmune disease develops. At present, treatment of autoimmune disease is based on generalised suppression of all immune responses, and is often needed to be lifelong, leading to long-term toxicities and suppression of protective immune responses against pathogens. A more targeted approach would be to reset the immune system via restoration of failing regulatory mechanisms, and redirect the immune system to a state of tolerance. Over the past decade there have been enormous advances in the understanding of basic processes that control immune tolerance, pushing regulatory T cells forward as targets for novel therapeutic strategies. This review describes the development of antigen-specific immunotherapy that targets the antigen-specific induction of regulatory T cells as a means to treat autoimmune disease. The ‘holy grail’ for autoimmunity is not the disease-causing antigen, but the disease-curing antigen.
PSO based droop control of inverter interfaced distributed generations

Often, there are several inverter interfaced distributed generations (IIDGs) in a Microgrid (MG). Each IIDG is connected to local loads and other IIDGs by one or several line. In this paper, an adaptive droop control method is presented that uses from line parameters between generation and consumption. Particle Swarm Optimization (PSO) is used to estimate optimal virtual line parameters. The impacts of active and reactive power fluctuations on voltage and frequency of MGs are presented. The results show that this method provides a desirable response of voltage and frequency under severe active and reactive changes in local loads.
Spectral microvolt T‐wave alternans testing has no prognostic value in patients recently hospitalized with decompensated heart failure

Microvolt T‐wave alternans (MTWA) testing identifies beat‐to‐beat fluctuations in T‐wave morphology, which have been linked to ventricular arrhythmias. However, clinical studies have produced conflicting results and data in heart failure (HF) have been limited. The aim of this study was to determine the prevalence and incremental prognostic value of spectral MTWA testing in an unselected cohort of patients recently hospitalized with HF.
The Effects of Organizational Factors on Knowledge Sharing

The purposes of this paper are to examine the influence of some organizational factors on the knowledge-sharing of members in Chinese context, and to discuss the implications of these factors for formulating organizational strategies that encourage knowledge sharing. Based on the theory of planning behavior (TPB), this paper focuses on the effects of the three factors (manager's behavior, organizational culture and organizational structure) on the members' knowledge sharing behaviors in the organizational context. Resulting from a survey of 306 firms in China, the research shows that management trustworthy behavior, two categories of organizational culture (sociability and solidarity) and the flexibility of organizational structure positively influence organizational members' knowledge sharing behavior. We conclude this paper with research's limitations, implications for practice and future research