Miracle-dz/UniFAR-FTUs huggingface dataset:
Studying the Effectiveness of Peer Instruction in Statics

This paper describes the peer instruction approach that was used in teaching Statics. The subject of Statics lays the foundation for subsequent courses, namely Dynamics and Mechanics of materials. Hence it becomes critical for any engineering student to understand and grasp the concepts of Statics course as it gives the students an ability to master follow-up material in upper level engineering courses. Therefore, improving learning in the subject of Engineering Statics deserves significant attention. Research shows that students who are actively engaged in learning, learn more. It was also proved that tradionally taught courses do little to improve student’s understanding of the key concepts and motivate only a few students in class. It is believed that peer instruction is an effective way to motivate students by making them teach their fellow students. This approach not only helps students learn core concepts and present it in technical language but also build their confidence. Results of this study indicated that post quiz scores improved for 71% of the students and 15% of students’ scores were 100 in both pre and post quizzes. The overall pass rate was 79% on quizzes and 79% on the final exam.
EEG microstate and functional brain network features for classification of epilepsy and PNES

• A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.
Development of a novel allograft model of prostate cancer: a new tool to inform clinical translation

Background Allograft models enable characterisation of genomic drivers and treatment responses by modelling immune and micro-environmental changes more accurately than xenografts. Despite this, few models are available to the prostate cancer (PCa) community. This study presents a novel allograft model of high-risk, localised PCa. In characterising this model we have focused on its response to radiotherapy (RT). Methods The DVL3 cell line was derived from a transgenic trp53-/-/Pten-/- mouse model and characterised both in vitro and in vivo. The DVL3 cells were allografted and response to RT was investigated and compared to the TRAMP-C1 model. Extensive tumour profiling in the DVL3 model was performed using flow cytometry, immunohistochemistry and RNA-seq. Results In vitro the DVL3 cells expressed basal and luminal markers. DVL3 cells formed tumours with distinct glandular morphology which expressed androgen receptor, similar to human localised PC. DVL3 tumour growth was delayed following administration of fractionated RT, with infiltration of myeloid derived suppressor cells (MDSC). Conclusions The DVL3 allograft model represents substantial progress in PCa modelling, displaying; luminal differentiation, strong AR expression, and an immunosuppressive microenvironment, similar to observations in high-risk PCa patients. This model is ideally suited for development and validation of novel therapeutics, in particular immune-modulatory agents in combination with RT.
After 37 Years WhatÃ¢ÂÂs in Store for IVF? A Look Ahead on the Trends andDevelopments That Are Shaping the Future of Reproductive Medicine

A breakthrough technological development enables clinicians to use oocyte precursor cells to rejuvenate eggs of patients who previously were unable to conceive or who produced consistently poorly formed embryos. This promising technology was developed based on research conducted by Jonathan Tilly, which was published in Nature [1]. Tilly, a researcher at Harvard Medical School and Massachusetts General Hospital, discovered egg precursor cells in the ovaries of adult mice that are capable of generating new eggs. Subsequent research confirmed that these precursor cells also exist in humans and have the ability to mature into fresh young eggs that can be harvested through an ovarian biopsy. In effect, immature egg cells in ovarian tissue could be used either to form new eggs or to rejuvenate women’s existing eggs. Such technology can significantly enhance the chances of conception for older women [2].
ROLE OF CLINICAL EXAMINATION AS SCREENING TOOL FOR DETECTION OF DEVELOPMENTAL DYSPLASIA OF HIP IN INFANTS.

Background: Developmental dysplasia of hip (DDH) is one entity one occasionally comes across while in a busy orthopaedic or paediatric outpatient department. The knowledge of risk factors and awareness of the condition is must for every orthopaedic surgeon and paediatrician as well lest the diagnosis will be missed. An early diagnosis can alter the prognosis of the disease and prevent late disabilities. Objective: The study was conducted to highlight the importance of screening every newborn to minimize the late presenting Developmental Dysplasia of Hip. Patients & Methods: In the one year duration 615 neonates were screened in Paediatric Nursery Department at a tertiary care hospital in Eastern India. by clinical examination and the findings were confirmed by a consultant orthopaedic surgeon. Results: Out of 615 neonates, 18 were suspected to have congenital hip dislocation. An acetabular index of 30 degrees or more was considered dysplastic. 3 out of 615 neonates were confirmed as dysplastic hips. Conclusion: This study indicates the need to establish a well-organized screening programme with experienced examiners which will be useful in making early and accurate clinical diagnosis.
Pembrolizumab (pembro) + chemotherapy (chemo) as neoadjuvant treatment for triple negative breast cancer (TNBC): Preliminary results from KEYNOTE-173.

556Background: Pembro has shown efficacy and acceptable safety in pts with previously treated metastatic TNBC. The phase Ib KEYNOTE-173 study (NCT02622074) evaluated pembro + chemo as neoadjuvant therapy for locally advanced TNBC. We present cohorts A and B. Methods: Women aged ≥18 y with locally advanced, nonmetastatic TNBC; ECOG PS 0/1; and no prior chemo, targeted therapy, or immunotherapy within 12 mo were eligible. Dosing in A was single-dose pembro followed by 4 cycles of pembro Q3W + nab-paclitaxel (Np) weekly followed by 4 cycles of pembro + doxorubicin + cyclophosphamide Q3W. Dosing in B was the same as in A but with carboplatin Q3W added to pembro + Np. Concentrations were pembro 200 mg; doxorubicin 60 mg/m2; cyclophosphamide 600 mg/m2; Np 125 mg/m2 in A, 100 mg/m2 in B; and carboplatin AUC 6 (1 cycle = 21 d). DLTs were assessed at cycles 1-3 and 6-7. Dose levels were deemed toxic if ≥3 of the first 6 pts or ≥4 of 10 pts had DLTs. Surgery was 3-6 wk after treatment completion/discontinuation. Pr.
Reconhecimento de Instrumentos de Percussão e Criação Automática de Arquivo Multipista

: Musical editing is usually limited when musical instruments are put together into a single audio track. Therefore, it is a matter of interest to identify mixed sounds and separate them into their respective tracks. This article proposes the automation of this process, more precisely, it aims to work with percussion instruments, isolating them in distinct tracks without the need of a musician or musical producer for such task. To achieve this, two approaches are used: the ﬁrst proposal uses digital ﬁlters, while the second involves machine learning concepts through the parameterization of audio stretches. In addition to recognizing the existence of a certain instrument in the mixed audio, the present work identiﬁes the time instants in which the sound of such an instrument occurs, thus allowing both the creation of distinct tracks as well as the choice of substitute instruments (samples). Resumo
Association between objective responses (OR) and overall survival (OS) in patients (pts) with metastatic Merkel cell carcinoma (mMCC) treated with avelumab.

193Background: Response rates are key efficacy endpoints in oncology trials, yet correlations with OS are not universal across cancer types. MCC is a rare and aggressive skin carcinoma, although it is chemo sensitive with high response rates, responses are of short duration with no demonstrated benefit to OS. This study explores the association between OR and OS in mMCC pts treated with the anti-PD-L1 avelumab. Methods: Efficacy data with ≥ 18 months of follow-up from Part A of the phase II avelumab trial (NCT02155647) were analyzed. Pts had prior progression on or after chemotherapy and received avelumab 10 mg/kg IV Q2W until confirmed progression, unacceptable toxicity, or withdrawal. Tumors were assessed for OR every 6 weeks (RECIST v1.1). Using conditional landmark analyses, OS was compared between pts with and without an independently confirmed OR up to day 47. Only pts alive at the landmark (day 47) are included in this analysis. In a sensitivity analysis, a landmark of 89 days was used. A Cox model.
Razones que pueden explicar la reducción en la cobertura de vacunación contra VPH en Colombia

La infeccion por el VPH es considerada una de las principales causas deneoplasias y preneoplasias asociadas a procesos infecciosos. Representaun problema de salud publica en paises desarrollados, pero especialmenteen aquellos que se encuentran en desarrollo. En respuesta a ello desde el2008 se introdujo en los esquemas de vacunacion la vacuna contra el VPHy en la actualidad se encuentra en mas de 120 paises. Una vez implementadala vacuna por el Programa Ampliado de Inmunizacion en Colombia,su cobertura se mostraba entre las mejores del mundo, pero lo ocurridoen 2014 en el Departamento de Bolivar impacto negativamente dicho comportamiento.Este articulo, haciendo uso de las Teorias de la Decision y laPercepcion, aborda el proceso realizado por los padres de familia para laeleccion de la no vacunacion como la accion mas benefica considerada.La autoridad sanitaria debe hacer frente a tres hechos que determinan suaceptacion por padres y adolescentes: el manejo de la incertidumbre quegenera la vacuna por dudas sobre su seguridad, el impacto de la comunicacionen la Era de la informacion y la incorporacion de la igualdad degenero en la formacion de las creencias, deseos e interpretaciones sobrela sexualidad, la reproduccion, el VPH y en general en todos los asuntosde la vida cotidiana con el fin de terminar con la disparidad entre mujeresy hombres en el ejercicio del poder y la toma de decisiones en todos losniveles.
Study of the effect of age, gender and seasonal variation on appendicitis in Azizyah-Iraq

Appendicitis is the most common acute surgical condition of the abdomen. The rate of acute appendicitis varies among countries. Declining rates of acute appendicitis have been reported in the United States and Europe. However, the frequency appears to be increasing in the developing countries. Age, gender and seasonal variations of acute appendicitis have been observed in many studies, but the reasons for these variations are not clear. Although acute appendicitis is a common surgical condition, little is known about its epidemiology in Iraq. Statistical analysis was done for 400 patients diagnosed as cases of appendicitis during a two year period from January 2013 to December 2014, treated in Azizyah hospital. Data were analyzed for age, sex, and season (month of admission). A total of 400 patients were diagnosed as cases of appendicitis. Appendicitis was more common in males (n=224, 56%) than females (n=176, 44%) with male to female ratio of 1.27:1, Highest rates of appendicitis was found in the age group of 10 to 19 years (n=158, 39.5%) and the lowest was 50 and more (n=11, 2.75%). Acute appendicitis high incident in November and December and lowest in June and July but it was high in March and April in teenage group.In the current study clear differences in the frequencies of appendicitis were noted the appendicitis has clear seasonality with highest rates in winter and spring season. Appendicitis rates were found to be higher in male gender than female. The prevalence peaks in teen age group
Die postoperative kognitive Störung: Entwicklungen und Perspektiven

Bildung, Hygiene, Nahrung, Arbeit, Medizin – unsere Lebensbedingungen sind gut und wir werden immer älter. Der Bevölkerungsanteil der über 67-Jährigen wird vom Statistischen Bundesamt für 2040 auf 21,5% vorhergesagt [2]. Mit dem Alter nehmen die körperlichen Reserven ab. Lebensalter ist der Risikofaktor für Demenz. Inouye et al. [3] zeigten: Ältere Patienten, die ein postoperatives Delir erlitten, starteten präoperativ auf einem niedrigeren kognitiven Level und zeigten auch bei Untersuchungen ein Jahr nach der Operation einen stärker ausgeprägten kognitiven Abbau als Patienten ohne postoperatives Delir.
Primary retrosternal goiter mimicking as teratoma of anterior mediastinum: A diagnostic enigma

Primary intrathoracic goiters arising from aberrant thyroid tissue are rare, representing <1% of all retrosternal goiters (RGs). We report a rare case of primary RG in a male patient with symptoms of mediastinal mass lesion alone. By careful examination and with the help of radiological imaging, we could pick up a thyroid swelling with a mediastinal mass which led to a diagnostic dilemma, as the thyroid swelling was reported as a multinodular goiter and the mediastinal mass was misdiagnosed as teratoma. We subjected the patient to a functional imaging with a thyroid scintigraphy, which revealed a thyroid swelling with retrosternal extension that was managed by surgery (total thyroidectomy and mediastinal mass excision) with only a Kocher's neck crease incision.
Association of Bone Mineral Density with Frailty, Pre-Frailty, and Osteoporosis in Community-Dwelling Elderly: A Prospective Study

Objectives: To examine the association of Bone Mineral Density (BMD) in the prediction of frailty, pre-frailty, osteoporosis, falls and health conditions in elderly men and women. Methods: A four-year prospective study (2009-2013) with 106 elderly, both sexes, aged ≥ 60 years, of the city of Goiânia, Brazil. BMD was estimated using dual-energy X ray absorptiometry. Frailty was assessed subjectively, including the following components: unintentional weight loss, fatigue, and low physical activity, reduction of strength and gait speed. Results: Mean age was 70 years of age and Body Mass Index (BMI) was 26.7 kg/m2. The mean BMD for women was 1.042 (± 0.11) g/cm2 while for men, mean BMD was 1.169 (± 0.12) g/cm2, (p = 0.000). After adjustments for age and BMI in women, lower BMD values were significantly associated with osteoporosis (p = 0.003), frailty (p = 0.033), and pre-frailty (p = 0.037). Conclusion: BMD was predictive of frailty, pre-frailty and osteoporosis in women. In men, no associations were established.
IMPACTO PSICOSSOCIAL DE PACIENTES CANDIDATOS A TRANSPLANTE DE FÍGADO

The psychosocial impact (PI) of familial caregivers (FC) on liver pre-transplant patients is assessed by a transversal and quantitative study undertaken at the HC of the UFMG, Brazil. Three tools were employed, namely, demographic and clinical characteristics and Zarit Inventory for PI. Data were analyzed by descriptive and comparative statistics with Shapiro-Wilk, χ2 and Kruskal-Wallis tests. Further, 73% of the 119 participants were males, aged 50 ± 12; 70% were married; 60% had basic schooling and 13% were employed. Highest percentage of FCs was made up of patients´ children, with α at 0.81. Relationship between males (0.018), schooling (0.014), encephalopathy (0.039), number of drugs (0.029) and happiness (0.028) with PI was reported. Highest schooling rate meant more happiness and, with less concomitant diseases, the lower was PI in FCs. Highest PI rate in FCs occurrred in male patients, with low schooling, with encephalopathy, when a concomitant disease and greater number of drugs occurred.
An Explorative Study to Prevent the Incidence of Inpatient Falls in a Tertiary Care Hospital

Improving patient care has become a top priority among healthcare providers, with the overall interest to achieve patient satisfaction. The quality of patient care is the adoption of a system which is patient centred or patient oriented. One such area in the hospital for improvising the quality of patient care is the prevention of patient falls. The study was carried out in the inpatients wards of a tertiary care hospital in Bangalore for a period of five months, from March 2018 to July 2018 which was cross sectional study descriptive in nature. Data on inpatient falls was collected through hospital incidence report for three years. An observational checklist was prepared to check for patient safety compliance to environmental circumstances and a self-administered questionnaire to assess the level of knowledge of nurses on fall prevention. Data analysis was done by using Quality control tools such as Pareto's Chart, Cause and Effect Diagram and bar graphs to identify the gaps and analyse the root cause for inpatient falls in the hospital. As a result of data analysis, it was concluded that the major reasons for patient falls were due to patient related factors such as old age, weakness, loss of balance, impaired cognition and environmental factors such as wet bathroom floors, absence of patient call bells and bed rails not being raised. On the other hand evaluating the level of knowledge of nursing staffs on fall prevention revealed that 3.25% of the nurses had poor knowledge regarding the fall risk assessment, 31.33% of the nurses had less knowledge on risk factors and 15.25% were not aware of interventions for fall reduction. Overall the hospital had to improve on fall prevention strategies and conduct periodic training programs for nurses on fall prevention. An environmental safety checklist was prepared and Standard fall prevention guidelines was formulated and recommended to the hospital.
Population structure and growth of the beaked clam Eumarcia paupercula (Bivalvia, Veneridae) in Maputo Bay, Mozambique

The edible beaked clam Eumarcia paupercula (Holten, 1802) is an abundant component of the intertidal infauna in Maputo Bay, Mozambique, and is an important source of food and income for local communities. This study investigates the population structure and estimates the growth rate of E. paupercula on a highly exploited tidal flat. Between November 2012 and April 2014, population structure was tracked by monitoring monthly length and density distributions, and growth rate was estimated using both mark-recapture experiments and length-frequency analysis (LFA). The population structure can be polymodal, bimodal or unimodal, as new cohorts of clams recruit to the population and older ones are fished or die out. The von Bertalanffy growth function Lt = 40.5 [1 – e–1.65(t – 0.03)] revealed that E. paupercula has a fast growth rate, equivalent to a phi-prime index (ϕ′) of 3.43, and a short lifespan of 1.97 years, similar to those of most other tropical venerid species. This article highlights that temporal population dynamics are strongly influenced by collection and reproductive patterns, and that single environmental parameters do not explain the patterns of growth. Understanding these factors will greatly facilitate development of management measures aimed at ensuring future sustainable exploitation of this species.
EGE ÜNİVERSİTESİ ORGAN NAKLİ MERKEZİNDE KARACİĞER TRANSPLANTASYONU ALICI VE DONÖRLERİNDEKİ FAKTÖR V LEİDEN GEN MUTASYONUNUN PREVALANSI

Karaciger transplantasyonu, son evredeki karaciger hastaliklarinda ve akut karaciger yetmezliginde rutin bir tedavi haline gelmistir. Koagulasyon faktorlerinden biri olan Faktor V karaciger tarafindan sentezlenmektedir. Koagulasyon faktor genlerindeki defektler, anormal veya derin ven tromboz gelisimi icin risk faktoru olusturabilecek yetersiz proteinlerin olusumuna sebep olmaktadir. Aktif protein C' ye karsi kazanilmis olan direnc (APCr) en sik karsilasilan koagulasyon anomalisidir ve % 90 – 95 oraninda faktor V Leiden mutasyonu sonucu gelismektedir. Bu mutasyon, G1691A genotiplemesi seklinde karakterize edilmektedir. Trombofilik anomalilerde canli donorlerin genotiplemesi mutlaka gerekmektedir. Karaciger transplantasyonu sonrasi olgularin yaklasik % 2.7' sinde derin ven trombozu gozlenmektedir. Bu amacla, organ alici ve donorlerinde FV Leiden gen mutasyonu analizi yapilmalidir. Calismamizda alici (191 kisi) ve donor (693 kisi) olarak Anabilim Dali' miza yollanan toplam 884 olgunun kan orneklerinden genomik DNA izole edilmis ve Faktor V Leiden mutasyonlari Real-time Online PCR ile saptanmistir. Toplam 884 olgunun dahil edildigi calismamizda FV Leiden gen mutasyonu icin 80 olgu heterozigot, uc olgu homozigot, 801 olgu normal genotipte oldugu belirlenmistir. Karaciger transplantasyonu sonrasinda, derin-ven trombozisi gelistiren hastalarin, donor karacigerinde homozigot Faktor V Leiden gen mutasyonu sonucu ortaya cikan sonradan kazanilmis aktive olmus Protein C (APC) rezistansi temeline dayandigi belirtilmistir. FV Leiden gen mutasyonunun rutin taramasi pre ve post operatif koagulasyonlarin kullanimi transplantasyon olgularinda tromboembolik komplikasyonlarin gelisimini onlemede uygun bir stratejidir. Sonuc olarak bu genotipleme, hem aliciyi hem de donorun trombozdan korunmasini saglamaktadir.
What determines young adults’ attitudes, perceived norms, and perceived behavioral control towards healthy sleep behaviors? A reasoned action approach

A common limitation to the design of public health sleep interventions is the overall lack of using theory. Previous researchers have utilized the theory of planned behavior and the reasoned action approach (RAA) to predict healthy sleep behaviors, however much of this research was done using reflective (or generalized) measures, which alone is likely inadequate to equip health practitioners with tangible information they can use to translate theory into practice. Therefore, the purpose of this study was to use formative (or belief-based) measures of the RAA to evaluate the determinants of attitudes, perceived norms, and perceived behavioral control (PBC) of healthy sleep behaviors among young adults. A survey was distributed via email using a university-wide listserv at a large southwestern university. Participants (n = 310) were on average 19.9 years old (+/-1.6), and reported sleeping five and a half hours (+/-0.7) per night. Associations between formative and reflective RAA measures were overall moderate to strong. Thinking clearly (r = 0.55; p < 0.001) was the strongest determinant of attitudes; friends (r = 0.27; p < 0.001) was the strongest referent of injunctive norms; children (r = 0.14; p < 0.05) was the strongest referent of descriptive norms; and having a lot of homework/studying (r = -0.25; p < 0.001) was the strongest determinant of PBC. Understanding the determinants of attitudes, perceived norms, and PBC will help health practitioners bridge the gap between theory and practice, and provide relevant information to aid in the development of effective public health sleep interventions.