Miracle-dz/UniFAR-FTUs huggingface dataset:
Nutritional Recommendations for Physique Athletes

Abstract The popularity of physique sports is increasing, yet there are currently few comprehensive nutritional guidelines for these athletes. Physique sport now encompasses more than just a short phase before competition and offseason guidelines have recently been published. Therefore, the goal of this review is to provide an extensive guide for male and female physique athletes in the contest preparation and recovery period. As optimal protein intake is largely related to one’s skeletal muscle mass, current evidence supports a range of 1.8-2.7 g/kg. Furthermore, as a benefit from having adequate carbohydrate to fuel performance and activity, low-end fat intake during contest preparation of 10-25% of calories allows for what calories remain in the “energy budget” to come from carbohydrate to mitigate the negative impact of energy restriction and weight loss on training performance. For nutrient timing, we recommend consuming four or five protein boluses per day with one consumed near training and one prior to sleep. During competition periods, slower rates of weight loss (≤0.5% of body mass per week) are preferable for attenuating the loss of fat-free mass with the use of intermittent energy restriction strategies, such as diet breaks and refeeds, being possibly beneficial. Additionally, physiological and psychological factors are covered, and potential best-practice guidelines are provided for disordered eating and body image concerns since physique athletes present with higher incidences of these issues, which may be potentially exacerbated by certain traditional physique practices. We also review common peaking practices, and the critical transition to the post-competition period.
How Does Orthorexia Nervosa Assessment Tools Can Differ – Comparison of Two Questionnaires: BOT and ORTO-15

Abstract The paper presents a comparison of the two most commonly used diagnostic tests for orthorexia – ORTO-15 Questionnaire and BOT (Bratman Orthorexia Test) – that use data-mining methods. Orthorexia nervosa is perceived as a new, unclassified eating disorder, which is characterized with pathological fixation on the consumption of healthy foods. In order to assess the coherence of the aforementioned tests, a method from the data-mining group, i.e. correspondence analysis, was used in addition to traditional statistical methods. On the basis of the obtained results, only average correlation between ORTO-15 Questionnaire and BOT test was found. More cases of orthorexia were diagnosed with the use of ORTO-15 Questionnaire, which may result from its higher sensitivity. It was also noted that the coherence of tests increases with increasing BMI values, despite no relationship between BMI and the presence of orthorexia having been proved. Diagnosis of an orthorexia case with the use of BOT test implies that there is a high probability that it will also be diagnosed with the use of ORTO-15 test, but not necessarily the other way around. The performed correspondence analysis confirmed a not very strong coherence of the results of both tests.
Attention Deficit Hyperactivity Disorder Detection – from Psychological Checklists to Mobile Solutions

Abstract The notion of Attention Deficit Hyperactivity Disorder (ADHD) may have its origins in 1763, when Scottish physician Sir Arthur Crichton observed people who could be easily distracted to a degree approaching the nature of delirium. Since then, the notion of ADHD matured and aroused controversy concerning whether it is a real illness and the motives behind particular methods of its treatments. Despite the controversy, ADHD is well established as a research subject and a frequently diagnosed disorder. Thus, the aim of this paper is not to deal with controversies but rather to show the evolution of methods used for the detection of this disorder. Literature analysis revealed that those methods varied from classical psychological tests/questionnaires to analyses of: eye-motion, micro-motion, brain activity, and behavioral patterns in virtual reality. The main conclusion is that the above methods tend to be heavily computer-aided and that the future belongs to mobile solutions incorporated into complex e-health systems.
Crystal structure of methyl 2-(4-(3-iodopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)acetate, C15H12IN3O2

Abstract C15H12IN3O2, triclinic, P1̄ (no. 2), a = 4.511(2) Å, b = 11.891(6) Å, c = 14.557(7) Å, α = 109.709(9)°, β = 96.971(9)°, γ = 97.054(9)°, V = 718.4(6) Å3, Z = 2, Rgt(F) = 0.0449, wRref(F2) = 0.1052, T = 293(2) K.
Corruption perceptions index and economic development of the country

Abstract The phenomenon of corruption is known all over the world, and its intensity varies according to economic, behavioral and educational factors. Transparency International is a global civil society that carries out regular opinion surveys and publishes the perceptions of corruption in countries around the world. This index identifies the level of corruption perceived in the world and contributes achieving a ranking of countries in this regard. The corruption perception index should be correlated with economic situation of a country. The economic situation of a country can be reflected by GDP and unemployment rate. The purpose of this study is to determine whether the index of corruption is influenced by the economic situation of a country, so the study analyses the corruption perception index, GDP and unemployment rate, establishing whether there is a link between them.
The phytosociology, ecology, and plant diversity of new plant communities in Central Anatolia (Turkey)

Abstract The Central Anatolian vegetation has diverse site conditions and small-scale plant diversity. For this reason, identification of plant communities is important for understanding their ecology and nature conservation. This study aims to contribute the syntaxonomical classification of the Central Anatolian vegetation. The study area is situated among Güzelyurt, Narköy, and Bozköy (Niğde) in the east of Aksaray province of Central Anatolia in Turkey. The vegetation data were collected using the phytosociological method of Braun-Blanquet and classified using TWINSPAN. The ecological characteristics of the units were investigated with Detrended Correspondence Analysis. Three new plant associations were described in the study. The steppe association was included in Onobrychido armenae-Thymetalia leucostomi and Astragalo microcephali-Brometea tomentelli. The forest-steppe association was classified under Quercion anatolicae in Quercetea pubescentis. The riparian association is the first poplar-dominated one described in Turkey and, classified under Alno glutinosae-Populetea albae and its alliance Populion albae.
The Effects of Compression Garments on Stability and Lower Limb Kinematics During a Forward Lunge

Abstract Compression garments have been used to minimise injury risk, through improvements in stability and joint positioning; yet, it is unclear whether there is an optimal length or tightness of these garments that may maximise observed benefits. This study measured the effect of three different garment types, at two different tightness levels, on lower extremity stability and alignment during a forward lunge movement. Sixteen healthy adults (7 female, 9 male; 24.3 ± 2.9 years) were recruited as participants. Stability of the lead foot, as well as lower body joint kinematics, were recorded using an Oqus 12-camera system, surrounding participants as they executed three forward lunges onto a Matscan pressure mat under seven compression conditions (Control, Light/Heavy Calf, Light/Heavy Socks, Light/Heavy Leggings). Mean minimum time-to-boundary (mmTtB) (derived from centre of pressure measures) and frontal plane kinematics (lateral pelvic tilt, knee valgus, ankle inversion/eversion) were used to assess the effect of garment tightness and length on lunge stability and joint alignment, respectively. A significant effect of tightness on mmTtB was observed (F(1,105) = 8.192; p = . 005, η2 = . 072), with Heavy garments eliciting longer mmTtB compared to their corresponding Light (-.18 ± .06 s; p = .015) or Control (-.28 ± .09 s; p = .007) conditions. No significant effects of garment tightness or length on lower body kinematics were evident. The results of this study suggest stability during a forward lunge is improved through the use of tight-fitted compression garments.
Food reward and gut-brain signalling

Abstract The increasing availability of ultra-processed, energy dense food is contributing to the spread of the obesity pandemic, which is a serious health threat in today’s world. One possible cause for this association arises from the fact that the brain is wired to derive pleasure from eating. Specifically, food intake activates reward pathways involving dopamine receptor signalling. The reinforcing value of specific food items results from the interplay between taste and nutritional properties. Increasing evidence suggests that nutritional value is sensed in the gut by chemoreceptors in the intestinal tract and the hepatic portal vein, and conveyed to the brain through neuronal and endocrine pathways to guide food selection behaviour. Ultra-processed food is designed to potentiate the reward response through a combination of high fat and high sugar, therebye seeming highly appetizing. There is increasing evidence that overconsumption of processed food distorts normal reward signalling, leading to compulsive eating behaviour and obesity. Hence, it is essential to understand food reward and gut-brain signalling to find an effective strategy to combat the obesity pandemic.
Understanding Player Load: Meanings and Limitations

Abstract We present a critical reflection on the mechanical variable Player Load, which is based on acceleration data and commonly used in sports. Our motivation to write this paper came from the difficulties that we encountered in the calculation and interpretation of Player Load using our own data, since we did not use the Catapult Sports equipment, which is a merchandise of the company that proposed this variable. We reviewed existing literature in order to understand Player Load better; we found many inconsistencies in PL calculation methods and in the meanings attached to it. Accordingly, this paper presents a brief discussion on the meanings that have been assigned to Player Load, its limitations, and the lack of clear and complete information about Player Load calculation methods. Moreover, the use of arbitrary units and different practical meanings in the literature has associated Player Load with many physical quantities, thereby resulting in difficulties in determining what Player Load measures within the context of sports. It seems that Player Load is related to the magnitude of changes in acceleration, but not the magnitude of acceleration itself. Therefore, coaches and sports scientists should take this information into account when they use Player Load to prescribe and monitor external loads. We concluded that a deeper discussion of Player Load as a descriptor of external load is warranted in the sports sciences literature.
The Forest Market – Income Methods for Determining the Value of Forest Resources

Abstract This article describes the methods for estimating the value of a forest, the accuracy of which is critical for purchases and sales, credit security, determining the shares in the division of forest real estate, as well as in determining the amount of compensation for losses in forest property. Compensation for property losses also includes past events that occurred before the Second World War, such as nationalization or loss of the forests in the eastern territories of the Second Polish Republic due to border changes. An equally important objective of forest valuation, which has recently gained in importance, is the inclusion of its value in a forest holding balance sheet. However, due to the lack of fully objective market prices for forest property, this work focused on the analysis of the quantitative and qualitative characteristics of the forest market and the methods of calculating the income (rent) value of the forest. Examples of commercial transactions from the forest market in the USA, Austria and Germany are included. The study presents a historical outline of forest valuation with particular emphasis on methods based on the income value, including forest rents. Furthermore, we discuss the formula of the perpetual capitalization of annuity and periodic annuity, including the impact of various net income calculations, that is, in arrears or in advance
The Burden of Knowledge in Mathematics

Abstract We investigate how the potential burden of processing ever more knowledge has affected the careers and research output of researchers in mathematics over the past 64 years. We construct a panel dataset of 48.851 researchers who published in ten top-ranking journals in mathematics. For this population of researchers, we supplement the dataset with years of birth from public sources. Our results show a significant increase of the average age of researchers at their first publication in one of our top-ranking journals, of the number of references of single-author articles, and of the number of coauthors that contribute to an article. Our findings extend earlier empirical findings on patents, as well as on researchers in economics, and hint at a burden of knowledge pervading different areas of human development. Moreover, our results indicate that researchers develop strategies like the division of labor to deal with this burden.
Progress in Microneedle-Mediated Protein Delivery

The growing demand for patient-compliance therapies in recent years has led to the development of transdermal drug delivery, which possesses several advantages compared with conventional methods. Delivering protein through the skin by transdermal patches is extremely difficult due to the presence of the stratum corneum which restricts the application to lipophilic drugs with relatively low molecular weight. To overcome these limitations, microneedle (MN) patches, consisting of micro/miniature-sized needles, are a promising tool to perforate the stratum corneum and to release drugs and proteins into the dermis following a non-invasive route. This review investigates the fabrication methods, protein delivery, and translational considerations for the industrial scaling-up of polymeric MNs for dermal protein delivery.
The American Association of Endocrine Surgeons Guidelines for the Definitive Surgical Management of Thyroid Disease in Adults.

OBJECTIVE To develop evidence-based recommendations for safe, effective, and appropriate thyroidectomy. BACKGROUND Surgical management of thyroid disease has evolved considerably over several decades leading to variability in rendered care. Over 100,000 thyroid operations are performed annually in the US. METHODS The medical literature from 1/1/1985 to 11/9/2018 was reviewed by a panel of 19 experts in thyroid disorders representing multiple disciplines. The authors used the best available evidence to construct surgical management recommendations. Levels of evidence were determined using the American College of Physicians grading system, and management recommendations were discussed to consensus. Members of the American Association of Endocrine Surgeons reviewed and commented on preliminary drafts of the content. RESULTS These clinical guidelines analyze the indications for thyroidectomy as well as its definitions, technique, morbidity, and outcomes. Specific topics include Pathogenesis and Epidemiology, Initial Evaluation, Imaging, Fine Needle Aspiration Biopsy Diagnosis, Molecular Testing, Indications, Extent and Outcomes of Surgery, Preoperative Care, Initial Thyroidectomy, Perioperative Tissue Diagnosis, Nodal Dissection, Concurrent Parathyroidectomy, Hyperthyroid Conditions, Goiter, Adjuncts and Approaches to Thyroidectomy, Laryngology, Familial Thyroid Cancer, Postoperative Care and Complications, Cancer Management, and Reoperation. CONCLUSIONS Evidence-based guidelines were created to assist clinicians in the optimal surgical management of thyroid disease.
Using a Website to Teach a Structured Reporting System, the Brain Tumor Reporting and Data System.

BACKGROUND The Brain Tumor Reporting and Data System (BT-RADS) is a proposed standardized radiology reporting scheme for magnetic resonance imagings in brain tumor patients. A website was created to introduce the classification system and to promote its use during daily radiology readouts with trainees. OBJECTIVES To demonstrate how a website can help implement a structured reporting at a tertiary academic facility. METHODS A website, www.btrads. com, including visual aids and an interactive scoring tool was developed to educate trainees about a structured reporting system for brain tumor magnetic resonance imagings. Number of website visitors, resource downloads, and scoring tool users was gathered during the study period of May 1, 2018 to April 30, 2019. Authors surveyed a group of 71 radiology trainees and 34 faculty physicians who care for brain tumor patients to assess the perceived educational and clinical value of BT-RADS. RESULTS The website was visited by 10,058 unique users in 1 year. The most commonly downloaded support material was the full guide (382 downloads). The interactive scoring tool was used 267 times. The use of BT-RADS at a single institution over 12 months reached over 70%. While survey results from trainees did not reach statistical significance, faculty oncologists, neurosurgeons, and radiologists felt that BT-RADS was a valuable clinical tool that improved interdisciplinary communication, facilitated educational discussions, and helped make treatment decisions. CONCLUSIONS A website designed to implement a novel structured radiology report facilitated template acceptance across a large neuroradiology section. Groups seeking to modify reporting practices should consider using a website.
Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies

Tauopathies are a disease group characterized by either pathological accumulation or release of fragments of hyperphosphorylated tau proteins originating from the central nervous system. The tau hypotheses of Parkinson’s and Alzheimer’s diseases contain a clinically diverse spectrum of tauopathies. Studies of case records of various tauopathies may reveal clinical phenotype characteristics of the disease. In addition, improved understanding of different tauopathies would disclose environmental factors, such as xenobiotics and trace metals, that can precipitate or modify the progression of the disorder. Important for diagnostics and monitoring of these disorders is a further development of adequate biomarkers, including refined neuroimaging, or proteomics. Our goal is to provide an in-depth review of the current literature regarding the pathophysiological roles of tau proteins and the pathogenic factors leading to various tauopathies, with the perspective of future advances in potential therapeutic strategies.
Desalted duck egg white peptides promoted osteogenesis via wnt/β-catenin signal pathway.

Osteoporosis is a degenerative disease that threatens bone health of the elderly (especially postmenopausal women). Since osteoporosis is important to prevent, the aim of this study was to investigate the regulation of desalted duck egg white peptides (DPs) on osteoporosis. In this study, the effects of DPs on bone formation were evaluated using MC3T3-E1 cells and ovariectomized (OVX) rats. DPs significantly enhanced the preosteoblasts proliferation, differentiation, and matrix mineralization via the upregulation of wnt3a expression, low-density lipoprotein receptor-related protein-5 (LRP-5), β-catenin, runt-related transcription factor 2 (Runx2), and osteoprotegerin (OPG) (P < 0.05). The intracellular calcium concentration was significantly elevated by DPs (P < 0.05), which is attributed to calcium influx and L-type calcium channels. Additionally, OVX rat model experiment indicated that DPs (600 mg/kg bw) had a superior effect against bone loss induced by estrogen deficiency, as it significantly declined bone turnover markers, and significantly increased biomechanical parameters (P < 0.05). Mineralized bone surfaces and bone microstructure were also obviously improved by DPs treatment. Immunohistochemical analysis showed that receptor activator of nuclear factor κ B (RANK) expression of tibia in DPs group was significantly reduced compared with the model group (P < 0.05). Our results demonstrated that DPs could enhance preosteoblasts differentiation and antiosteoporosis via wnt/β-catenin signal pathway and several key osteogenic transcription factors such as Runx2 and OPG. PRACTICAL APPLICATION: High-value utilization of salted duck egg white, a byproduct of food industry, is worthy of in-depth study. Desalted duck egg white peptides (DPs) were proved to promote bone formation, which suggests the potentials of DPs as cofactors in osteoporosis prevention.
A Deep Segmentation Network of Multi-Scale Feature Fusion Based on Attention Mechanism for IVOCT Lumen Contour

Recently, coronary heart disease has attracted more and more attention, where segmentation and analysis for vascular lumen contour are helpful for treatment. And intravascular optical coherence tomography (IVOCT) images are used to display lumen shapes in clinic. Thus, an automatic segmentation method for IVOCT lumen contour is necessary to reduce the doctors’ workload while ensuring diagnostic accuracy. In this paper, we proposed a deep residual segmentation network of multi-scale feature fusion based on attention mechanism (RSM-Network, Residual Squeezed Multi-Scale Network) to segment the lumen contour in IVOCT images. Firstly, three different data augmentation methods including mirror level turnover, rotation and vertical flip are considered to expand the training set. Then in the proposed RSM-Network, U-Net is contained as the main body, considering its characteristic of accepting input images with any sizes. Meanwhile, the combination of residual network and attention mechanism is applied to improve the ability of global feature extraction and solve the vanishing gradient problem. Moreover, the pyramid feature extraction structure is introduced to enhance the learning ability for multi-scale features. Finally, in order to increase the matching degree between the actual output and expected output, the cross entropy loss function is also used. A series of metrics are presented to evaluate the performance of our proposed network and the experimental results demonstrate that the proposed RSM-Network can learn the contour details better, contributing to strong robustness and accuracy for IVOCT lumen contour segmentation.
Spiderweb-like metal-organic framework multifunctional foam.

Processing metal-organic-frameworks (MOFs) into hierarchical macroscopic materials can greatly extend their practical applications. However, current strategies suffer from severe aggregation of MOFs and limited tuning of the hierarchical porous network. Here, we report a controlled strategy that can simultaneously tune the MOF loading, composition, spatial distribution, and confinement within various bio-originated macroscopic supports, as well as control the accessibility, robustness, and formability of the support itself. Our methodology enables the good dispersion of individual MOF nanoparticles on a spiderweb-like network within each macrovoid even at high loadings (up to 86 wt%), ensuring the foam pores are highly accessible for excellent adsorption and catalytic capacity. Additionally, this approach allows the direct pre-incorporation of other functional components into the framework . Our strategy provides a general toolbox for precise control over the properties of both the hierarchical support and MOF, opening new possibilities to construct tunable multi-scale porous platforms with desired functionalities .