Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation between number of mature eggs retrieved and live birth rate in IVF treatment

Background: There is a strong association between the number of eggs and clinical pregnancy rates. But a few studies have shown conflicting results. Aim was to determine the relation between number of mature eggs retrieved and live birthrate in one complete IVF cycle (fresh and all frozen transfers included) and hence determine the optimum number of oocytes. Private IVF centre doing around 2000 cycles per year. Methods: Retrospective analysis of 1140 infertile women between 20 and 45 years who underwent self-stimulation IVf in our centre. Cumulativelive birth rate in one complete IVF cycle. Secondary outcome was the number of cases of moderate and severe OHSS. Results: Maximum LBR in patients where 10-15 egg were retrieved in fresh embryo transfer and cumulative LBR was maximum when more than 15 eggs were retrieved. No case of severe OHSS and one case of moderate OHSS in the group where more than 15 eggs were retrieved. Conclusions: The percentage of live birth increases with increasing number of mature eggs in IVF treatment. The incidence of OHSS was negligible.
Evaluation of Sucrose Laurate as an Intestinal Permeation Enhancer for Macromolecules: Ex Vivo and In Vivo Studies

Oral delivery of macromolecules requires permeation enhancers (PEs) adaptable to formulation. Sucrose laurate (SL) (D1216), a food grade surfactant, was assessed in Caco-2 monolayers, isolated rat intestinal tissue mucosae, and rat intestinal instillations. Accordingly, 1 mM SL increased the apparent permeability coefficient (Papp) of [14C]-mannitol and reduced transepithelial electrical resistance (TEER) across monolayers. It altered expression of the tight junction protein, ZO-1, increased plasma membrane potential, and decreased mitochondrial membrane potential in Caco-2 cells. The concentrations that increased flux were of the same order as those that induced cytotoxicity. In rat colonic tissue mucosae, the same patterns emerged in respect to the concentration-dependent increases in paracellular marker fluxes and TEER reductions with 5 mM being the key concentration. While the histology revealed some perturbation, ion transport capacity was retained. In rat jejunal and colonic instillations, 50 and 100 mM SL co-administered with insulin induced blood glucose reductions and achieved relative bioavailability values of 2.4% and 8.9%, respectively, on a par with the gold standard PE, sodium caprate (C10). The histology of the intestinal loops revealed little damage. In conclusion, SL is a candidate PE with high potential for emulsion-based systems. The primary action is plasma membrane perturbation, leading to tight junction openings and a predominant paracellular flux.
Self-Adaptive Filtering Approach for Improved Indoor Localization of a Mobile Node with Zigbee-Based RSSI and Odometry

This study presents a new technique to improve the indoor localization of a mobile node by utilizing a Zigbee-based received-signal-strength indicator (RSSI) and odometry. As both methods suffer from their own limitations, this work contributes to a novel methodological framework in which coordinates of the mobile node can more accurately be predicted by improving the path-loss propagation model and optimizing the weighting parameter for each localization technique via a convex search. A self-adaptive filtering approach is also proposed which autonomously optimizes the weighting parameter during the target node’s translational and rotational motions, thus resulting in an efficient localization scheme with less computational effort. Several real-time experiments consisting of four different trajectories with different number of straight paths and curves were carried out to validate the proposed methods. Both temporal and spatial analyses demonstrate that when odometry data and RSSI values are available, the proposed methods provide significant improvements on localization performance over existing approaches.
Stem Cells from Human Exfoliated Deciduous Teeth: Biology and Therapeutic Potential

Stem cells isolated from human exfoliated deciduous teeth (SHEDs) are a type of mes‐ enchymal stem cells (MSCs), widely investigated for regenerative treatment. They are isolated from dental pulp tissues remaining in physiologically shedding human decidu‐ ous teeth. Thus, SHEDs are easy to access and not required invasive procedure to obtain cells. SHEDs are multipotent mesenchymal stem cells; however, they possess distinct properties when compared to other MSCs. In this regard, SHEDs exhibit higher pro‐ liferative rate than bone marrow‐derived MSCs and greater osteogenic differentiation potency than human dental pulp stem cells. This chapter reviews the isolation technique and basic characteristics of SHEDs. Moreover, the intracellular signalling involved in the stemness regulation and differentiation ability of SHEDs is discussed, particularly on fibroblast growth factor, Notch, and Wnt signalling. Finally, the potential regenerative therapeutic application of SHEDs is also described.
Storage media for avulsed teeth: review of literature

Tooth avulsion is a traumatic injury which can cause severe consequences to permanent dentition, because of the possible damage to periodontal structure. Immediate replantation is the best procedure. However, it sometimes cannot be performed and the success depends on the duration of extra-alveolar time and storage medium of the tooth. The objective of this paper is to review the literature about storage media due to its importance to replantation prognosis. Although innumerous storage media have been tested until now, none of them has the biological requirements and is available at the local accident. Saliva and water are easily accessible, although causing deleterious effects on periodontal cells. Growth factors have biological effects, though they are inaccessible. Thus, its use is impracticable. Propolis and green tea extract seem to be promising and new researches should be carried out. Milk, specially skimmed long shelf-life, seems to be a good option due to its cell viability good results besides its accessibility.
Effect of NaCl on Growth and Development of in vitro Plants of Date Palm (Phoenix dactylifera L.) ‘Khainazi’ Cultivar

Background and Objectives: High salinity of soil and water resources is a global issue which is causing substantial decline of productive lands in many arid and semiarid regions of the world due to salinization. Therefore, the main objective of this study was to determine the effect of NaCl on growth and development of in vitro plants of date palm (Phoenix dactylifera L.) ‘Khainazi’ cultivar. Materials and Methods: The study was carried out in the Tissue Culture Laboratory, Date Palm Research Center, King Faisal University, Kingdom of Saudi Arabia. Ten date palm offshoots of cv. Khainazi, about 3-4 years old and weighing 5-7 kg were used in the experiment. The shoot tip and lateral buds were sterilized in 20% v/v clorex solution for 15 min and then sectioned into 1 cm explants for culture initiation. The modified MS media was supplemented with different concentrations of NaCl ranging from 0, 50, 100, 200, 300 and 400 mmol LG1 and incubated at 25±2EC for 16 h in light daily supplied by 65/80 Warm White Weisse 3500 fluorescent tubes. Each treatment was replicated 10 times by following a completely randomized design. Plant observations included dry weight of shoots and roots and length of stem and roots. The concentration of Na, Mg, Ca and K in plant roots and shoots were determined by the Atomic Absorption Spectrophotometer while Cl by a Chloride meter. Experimental data were analyzed by following appropriate statistical procedures. Results: Stem and root length and dry weight were progressively reduced in most of the treatments by the addition of 0, 50, 100, 200, 300 and 400 mmol LG1 to the growth medium. The reduction in shoot, however, was greater than root. The concentration of Na increased significantly both in the shoots and roots. While the concentration of Ca, Mg and K increased with the addition of NaCl up to 100 mmol LG1, then decreased with increasing the NaCl concentration up to 400 mmol LG1 in the growth medium. Conclusion: Addition of high NaCl concentration to growth medium for the development of date palm off-shoots using tissue culture technology did not show encouraging results. In conclusion, addition of NaCl solution having concentration above 100 mmol LG1 to growth medium proved detrimental to explants to obtain desired date palm off shoots.
Aalborg Universitet Radio Propagation into Modern Buildings

Energy-efficient buildings are gaining momentum in order to comply with the new energy regulations. Especially in northern cold countries, thick reinforced walls and energyefficient windows composed of several layers of glass plus metal coating are becoming the de facto elements in modern building constructions, and it has been noticed that they can impact heavily on radio signal propagation. This paper presents a measurement-based analysis of the outdoor-to-indoor attenuation experienced in several modern constructions compared to an old building. The measurements are performed for frequencies from 800 MHz to 18 GHz with the aim of identifying the frequency dependence and the impact of the new materials on not only the cellular frequency bands used today (mainly below 3 GHz), but also the potential future bands (above 3 GHz). The results show a material dependent and a frequency dependent attenuation, with an average increase of 20-25 dB in modern constructions compared to the old construction, which presents a low and almost constant attenuation below 10 dB. The different measurement results and observations presented along the paper are useful for future radio network planning considerations.
Fast and Reftned Radar Processing For Maneuvering Target via Two-stage Integration Detection

Reliable and fast detection of maneuvering target in complex background is important for both civilian and military applications. It is rather difficult due to the complex motion resulting in energy spread in time and frequency domain. Also, high detection performance and computational efficiency are difficult to balance in case of more integration pulses. In this paper, we propose a fast and refined processing method of radar maneuvering target based on hierarchical integration detection, utilizing the advantages of moving target detection (MTD), fractional Fourier transform (FRFT) and fractional ambiguity function (FRAF). The method adopts two-stage threshold processing. The first stage is the coarse detection processing screening out the range units having possible moving targets. The second stage is called the refined processing, which uses FRFT or FRAF for coherent integration dealing with high-order motions, i.e., accelerated or jerk motion. And the second stage is carried out only within the rangebins after the first stage. Therefore, the amount of calculation can be greatly reduced while ensuring high detection performance. Finally, real radar data are used for verification of the proposed method, which shows better performance than the traditional MTD method with higher integration gain.
Epidemiology of Animal Bite Injuries in Golestan Province, Northeast of Iran, during 2011-12

Introduction: Animal bite is a public health problem worldwide. The aim of this study was to investigate frequency of animal bites in Golestan province, northeast of Iran, between 2011 and 2012. Methods: This descriptive cross-sectional study was done by collecting data from medical records of animal bite victims referred to the health centers in the Golestan province, in 2011-12. Information collected included species of animals, gender, age, occupation, location of residence, type of treatment, and type of injury. The data were analyzed by SPSS (version 16). Results: Overall, there were 10,810 incidents of animal bites in the province in 2011-12. Of these cases, 8125 (75.48%) were men and most cases were 5-24 years of age. Dog bites accounted for 9885 (91.44%) cases of animal bites. Most incidents occurred in rural areas (82.27%). Most vulnerable individuals were students (n=2370, 21.92%) and homemakers (n=1722, 15.93%). The most common site of animal bites was lower limb (62.53%). Moreover, treatment with anti-rabies serum and vaccine was done for 9610 (89.9%) and 9068 (83.89%) cases, respectively. Conclusions: According to our results, animal bites are more frequent in young men, residents of rural areas, and students. In addition, dog bites account for 91% of all cases of animal bites in the province. These results highlight the need for education programs on animal bites and rabies to increase knowledge and awareness of the individuals at risk.
Optimized time-delayed feedback control of fractional chaotic oscillator with application to secure communications

In this paper new type of time-delayed feedback control is designed based on particle swarm optimization method. This controller is used in the control of chaotic behavior of fractional order chaotic oscillator. Using a discretization method practical realization of the proposed system has been done. Also secure communication using the designed method is done. Simulation results show the performance of the designed controller.
Association between Caribbean sponges and photosynthetic organisms

Five types of associations between sponges and endobiotic autotrophs were discovered in Belize and Bermuda and are currently under study. At least 21 species of common and large shallow-water sponges (genera Ircinia, Aplysina, Verongula, Cribochalina, Xestospongia, Neofibularia, Ulosa, Geodia, Chondrilla) contain Aphanocapsa-type unicellular blue-green algae (cyanobacteria). One spongiid, Oligoceras violacea, is permeated by filaments of a Phormidium species, an oscillatorian cyanobacteria. Two species of clionid sponges, Chona caribbaea and C. varians, contain dinophycean zooxanthellae. Mycale laxissima (Mycalidae), 1gernella notabilis (Darwinellidae), and at least one unidentified dendroceratid were found to harbor two species offilamentous algae embedded in the spongin fibers of their skeletons; one, Ostreobium, is a chlorophyte, the other, Acrochaetium, a rhodophyte. Two sponges substitute their skeletons with live calcified red algae. Dysideajaniae (Dysideidae) is supported byJania adherens, Xytopsues osbornensis (Myxillidae) by j. capillaria. All reported cases have parallels in the Mediterranean Sea or in the IndoPacific region but are difficult to compare because important new data, on ultrastructure and pigment properties are subject to variables that are not yet fully understood. Observations and experiments provide evidence that both partners generally profit from the symbiosis-the sponges by obtaining food supplements or body support, the plants by gaining nutrients and protection from grazers. For more than a century biologists have been aware of the association between sponges and photosynthetic organisms (cyanobacteria or Cyanophyta, several groups of eukaryotic algae) (see Fcldmann, 1933, and the literature cited therein), but research on the types of relationships between them did not begin in earnest until the 1970s.
Development and Validation of a Mobile Application for Measuring Femoral Anteversion in Patients With Cerebral Palsy

Supplemental Digital Content is available in the text. Background: Computed tomography (CT) provides benefits for 3-dimensional (3D) visualization of femur deformities. However, the potential adverse effects of radiation exposure have become a concern. Consequently, a biplanar imaging system EOS has been proposed to enable reconstruction of the 3D model of the femur. However, this system requires a calibrated apparatus, the cost of which is high, and the area occupied by it is substantial. The purpose of this study was to develop a mobile application that included a new method of 3D reconstruction of the femur from conventional radiographic images and to evaluate the validity and reliability of mobile the application when measuring femoral anteversion. Methods: The statistical shape model, graph-cut algorithm, and iterative Perspective-n-Point algorithm were utilized to develop the application. The anteroposterior and lateral images of a femur can be input using the embedded camera or by file transfer, and the touch interface aids accurate contouring of the femur. Regarding validation, the CT scans and conventional radiographic images of 36 patients with cerebral palsy were used. To evaluate concurrent validity, the femoral anteversion measurements on the images reconstructed from the mobile application were compared with those from the 3D CT images. Three clinicians assessed interobserver reliability. Results: The mobile application, which reconstructs the 3D image from conventional radiographs, was successfully developed. Regarding concurrent validity, the correlation coefficient between femoral anteversion measured using 3D CT and the mobile application was 0.968 (P<0.001). In terms of interobserver reliability, the intraclass correlation coefficient among the 3 clinicians was 0.953. Conclusions: The measurement of femoral anteversion with the mobile application showed excellent concurrent validity and reliability in patients with cerebral palsy. The proposed mobile application can be used with conventional radiographs and does not require additional apparatus. It can be used as a convenient technique in hospitals that cannot afford a CT machine or an EOS system. Level of Evidence: Level III—diagnostic.
Are there really conformal frames? Uniqueness of affine inflation

Here, we concisely review the nonminimal coupling dynamics of a single scalar field in the context of purely affine gravity and extend the study to multifield dynamics. The coupling is performed via an affine connection and its associated curvature without referring to any metric tensor. The latter arises a posteriori and it may gain an emergent character like the scale of gravity. What is remarkable in affine gravity is the transition from nonminimal to minimal couplings which is realized by only field redefinition of the scalar fields. Consequently, the inflationary models gain a unique description in this context where the observed parameters, like the scalar tilt and the tensor-to-scalar ratio, are invariant under field reparametrization. Overall, gravity in its affine approach is expected to reveal interesting and rich phenomenology in cosmology and astroparticle physics.
Cdc42 Couples T Cell Receptor Endocytosis to GRAF1-Mediated Tubular Invaginations of the Plasma Membrane

T cell activation is immediately followed by internalization of the T cell receptor (TCR). TCR endocytosis is required for T cell activation, but the mechanisms supporting removal of TCR from the cell surface remain incompletely understood. Here we report that TCR endocytosis is linked to the clathrin-independent carrier (CLIC) and GPI-enriched endocytic compartments (GEEC) endocytic pathway. We show that unlike the canonical clathrin cargo transferrin or the adaptor protein Lat, internalized TCR accumulates in tubules shaped by the small GTPase Cdc42 and the Bin/amphiphysin/Rvs (BAR) domain containing protein GRAF1 in T cells. Preventing GRAF1-positive tubules to mature into endocytic vesicles by expressing a constitutively active Cdc42 impairs the endocytosis of TCR, while having no consequence on the uptake of transferrin. Together, our data reveal a link between TCR internalization and the CLIC/GEEC endocytic route supported by Cdc42 and GRAF1.
Inflation and Sustainable Output Performance in the West African Sub-Region: The Threshold Effect

The question as to what the optimal level of inflation should be that would engender maximu m output performance has been a crucial issue over the decades. This paper empirically exp lores the issue of the existence of threshold effect in the present relat ionship between inflation and economic growth in the con text of West African economies. The study is imperat ive due to the superficiality and gaps in the existing literatures in exp loring the issue of the existence of threshold effect in determin ing the relationship between inflat ion and economic gro wth in the sub -region in terms coverage of issues, analytical framework and methodology. The study covers four countries in the West African reg ion: Burkina Faso, Ghana, Nigeria and Senegal for the period 1980-2009. Findings fro m the empirical results strongly suggest the existence of a threshold level of 9% beyond which inflation exerts a negative effect on growth. The West African reg ion should prioritize attention to maintaining a relatively low and stable inflation rate if the goal of attain ing steady and rapid economic growth is to be achieved.
Gallbladder Carcinoma, Improving Diagnosis and Outcome

Objective: The purpose of this study is to determine the pattern of presentation of carcinoma of the gall bladder in Saudi patients and to assess the accuracy of diagnostic modalities, namely ultrasound and computerized scan, in detecting the disease, together with an extensive literature review to establish suspicious criteria helping in early diagnosis of this lethal disease.Methods: This is a retrospective study of patients diagnosed to have gallbladder carcinoma at King Fahad Medical City, Riyadh, K.S. A. in the period from January 2007 to January 2010.Results: Six patients were included, 5 females and one male (age range between 58 and 87 years, with a mean age of 73 years. The main presenting symptoms were abdominal pain (83.3%), nausea and vomiting (50%). Two patients were found to be jaundiced (33.3%), an abdominal mass was felt in one patient (16.6 %) and weight loss was seen in 4 patients (66.7%). Liver function test showed abnormal liver enzymes in 3 patients (50%), elevated bilirubin in two patients (33.3%), elevated alkaline phosphatase in 4 patients (66.7%) and low albumin in all patients (100%). Low hemoglobin was observed in 2 patients (33.3%). abdominal ultrasound was suspicious for gallbladder carcinoma in two patients (33.3 %), gallstones and chronic cholecystitis were found in the remaining 4 patients. CT scan was performed in 4 patients and it was suspicious of gallbladder cancer in all of them (100%). It detected evidence of liver invasion and hepatic metastasis in one of the 2 operated cases; however, it failed to detect liver invasion in one of the operated patients who subsequently was proved to have liver invasion on histological examination of the liver resection specimen. Histology confirmed diagnosis of adenocarcinoma in all patients with variable degree of differentiation.Conclusions:The poor prognosis of gallbladder cancer is related to its dissemination capacity and usually late diagnosis due to its non-specific clinical presentation. The traditional routine approach of investigation and management of patients with gallbladder stones which depends mainly on ultrasound as diagnostic modality may delay the diagnosis and waste the chance of early detection of gallbladder carcinoma when curative resection is achievable. We recommend a high index of suspicion in patients with gallstones in presence of a combination of female sex, old age, silent gallstones presenting at late age, and thickened wall of the gallbladder on ultrasonic examination. We also recommend adding more sensitive investigation like CT scan, EUS, and ultrasound-guided aspiration cytology/biopsy to the protocol of investigation of these patients.