Miracle-dz/UniFAR-FTUs huggingface dataset:
Direction of Arrival Estimation in a Multipath Environment : an Overview and a New Contribution ( Invited Paper )

This paper proposes a new computationally efficient algorithm for direction-of-arrival (DOA) estimation in a multipath environment using a uniform linear array (ULA) of equispaced sensors. The paper starts by presenting a comprehensive overview of the classical MUSIC algorithm used for DOA estimation of uncorrelated signals. The effect of different factors related to the signal environment as well as the sensor array is investigated. The concept of spatial smoothing required in the case of correlated signals encountered in multipath propagation environments is then discussed. This then leads to the development of a new computationally efficient DOA estimation algorithm that is proposed for a multipath environment with unknown correlated signals. The algorithm comprises two stages: a first stage for discriminating uncorrelated signals, and a second stage for resolving the directions of arrival of correlated signals using covariance differencing and iterative spatial smoothing. Simulation results show that the proposed algorithm operates at a much lower computational cost compared to standard methods. The proposed algorithm also offers a hardware saving by reducing the number of sensors required to detect a given number of signals.
Veterinary public health and Alexander D. Langmuir.

Alexander Duncan Langmuir was recruited by the late Joseph Mountin, as I (1. H. S.) was after World War II, with the challenge to explore new areas that related to public health. Mountin was a leader who gained fame by challenging the old order and anticipating future needs (1). He foresaw the need for an agency such as the Communicable Disease Center (now the Centers for Disease Control and Prevention (CDC)) to service the states. In 1942, the Office of Malaria Control in War Areas was established by the Public Health Service in Atlanta, Georgia, to devise methods to reduce the incidence of malaria in our troops. This office also cooperated actively with the states in an intensive campaign to control malaria throughout the South where it was endemic. On January 1, 1946, following the war, a disease investigation and training center, the CDC, replaced the Office of Malaria Control in War Areas. The establishment of the CDC was the fulfillment of Mountin's foresight. He believed that the Public Health Service should have a field office that could provide state health agencies with the technical help of consultants with highly specialized knowledge and skills, and it came to be. Mountin's challenge to me (1. H. S.) in 1945 was succinct: "What are you veterinarians going to do for public health now that the war is over? " Further questioning by Mountin led to an order from him that I should prepare a list of zoonotic/animal diseases that affect human health. The resulting chart (2) inevitably led Mountin to ask what control measures could be put into effect. It was apparent that the epidemiology of most zoonotic diseases was not known, and control was not understood. Mountin summarized the situation by saying, "It appears that we have a lot of
Can a Pulmonary Health Teaching Program Alter Patients’ Ability to Cope with COPD?

&NA; Many clinical nurse specialists (CNSs) are involved in providing group teaching programs for individuals with chronic obstructive pulmonary disease (COPD). Although knowledge levels often are enhanced by these programs, what is less well known is whether such programs also can affect the coping methods used by those with this disease. The exploratory study described here was part of a larger research project aimed at determining patients’ knowledge, specific psychological parameters (anxiety, hostility, depression), and coping strategies. Thirty people agreed to participate in the study. The Jalowiec Coping Scale (JCS) (Jalowiec & Powers, 1981) was used so that participants could rate each coping method according to the degree of use and to determine whether the methods employed were affective or problem‐solving approaches. There was very little change in the pre‐ and posttest scores on the JCS, indicating that there was little change in coping strategies used. There also were no significant correlations between the JCS scores and the demographic characteristics of age, educational level, and the length of time since diagnosis of COPD. The results of this study seem to indicate that pulmonary rehabilitation programs should place more emphasis on appropriate coping strategies that the COPD patient can incorporate into his or her lifestyle.
Title: “Kelly’s Syndrome”- prevention, using Implant Supported Hybrid Denture: Clinical Considerations and Case Report with 5 year follow up.

The prosthetic rehabilitation of patients with an edentulous maxilla opposing mandibular anterior natural teeth is one of the most challenging situations that a clinician encounters. Occlusal forces from the opposing natural teeth may cause fractures in the maxillary prosthesis and also result in residual ridge resorption of the edentulous maxilla. Prosthodontists try overcoming this Combination syndrome by careful treatment planning, which may require a multi-disciplinary approach involving surgical intervention followed by metallic denture base prosthesis, implant supported fixed prosthesis, implant supported overdentures etc. Even conventional prosthodontic techniques with special consideration for flabby tissues, over denture prosthesis and removable cast partial denture may be used. Choice of treatment modality is made by keeping in mind that the requirement of stability and retention of the prosthesis must be balanced along with the preservation of the health of the remaining oral tissues for every patient. With the presence of extreme gagging reflex, the treatment may become even more complicated. This article describes and illustrates the two stage surgical and prosthetic treatment of a patient with an edentulous maxilla opposing mandibular anterior natural teeth. The extreme gagging reflex from maxillary conventional complete denture and the occlusal forces from the mandibular anterior natural teeth compelled the clinician to adapt a different treatment plan which included placement of 4 endosseous implants in maxilla followed by fabricating a maxillary fixed screw retained hybrid prosthesis, and 4 implants in posterior mandible for implant supported Fixed Partial Denture.
Distinctions between Bovine Herpesvirus 1 and Herpes Simplex Virus Type 1 VP22 Tegument Protein Subcellular Associations

ABSTRACT The alphaherpesvirus tegument protein VP22 has been characterized with multiple traits including microtubule reorganization, nuclear localization, and nonclassical intercellular trafficking. However, all these data were derived from studies using herpes simplex virus type 1 (HSV-1) and may not apply to VP22 homologs of other alphaherpesviruses. We compared subcellular attributes of HSV-1 VP22 (HVP22) with bovine herpesvirus 1 (BHV-1) VP22 (BVP22) using green fluorescent protein (GFP)-fused VP22 expression vectors. Fluorescence microscopy of cell lines transfected with these constructs revealed differences as well as similarities between the two VP22 homologs. Compared to that of HVP22, the BVP22 microtubule interaction was much less pronounced. The VP22 nuclear interaction varied, with a marbled or halo appearance for BVP22 and a speckled or nucleolus-bound appearance for HVP22. Both VP22 homologs associated with chromatin at various stages of mitosis and could traffic from expressing cells to the nuclei of nonexpressing cells. However, distinct qualitative differences in microtubule, nuclear, and chromatin association as well as trafficking were observed. The differences in VP22 homolog characteristics revealed in this study will help define VP22 function within HSV-1 and BHV-1 infection.
Plasmic degradation modulates activity of fibrinogen‐bound fibroblast growth factor‐2

Summary. Fibroblast growth factor‐2 (FGF‐2) binds to fibrin(ogen) with high affinity, and fibrinogen potentiates FGF‐2‐stimulated proliferation of endothelial cells. Because plasmin degrades fibrin(ogen) physiologically and could liberate growth factor from fibrin deposits or alter its activity, we have now investigated the effect of plasmic degradation on the activity of fibrin(ogen)‐bound FGF‐2. Fibrinogen with bound FGF‐2 was incubated with plasmin, the products characterized by SDS–PAGE, and the proliferative activity determined by 3H‐thymidine incorporation into endothelial cells. Before plasmin exposure, proliferation was increased 3.7 ± 0.6‐fold with fibrinogen‐bound FGF‐2 compared with medium alone (P < 0.005). Plasmic degradation resulted in progressive decrease in the proliferative capacity, with the 60‐min digest showing predominantly fragment D1 and E and 3H‐thymidine uptake of only 1.2 ± 0.2‐fold, significantly less than the activity of an equal concentration of free FGF‐2 (P < 0.02). However, further degradation increased activity, and proliferation with a 90‐min digest increased to 2.6 ± 0.5‐fold, significantly greater than the 60‐min digest (P < 0.02). Plasmic degradation in the presence of 10 mm calcium chloride prevented degradation of D1 to D2 and D3, and the activity did not increase with extended degradation. Immunoprecipitation of the digests with antifibrinogen antibody showed 70 ± 8% of fibrinogen‐bound FGF‐2 in the presence of calcium but only 15 ± 4% in its absence, indicating that cleavage of D1 to D2 and D3 is critical in binding. Fragment D1 and D2, but not D3, bound to a column containing immobilized FGF‐2, indicating that a binding site is lost upon degradation to D3. The results demonstrate that plasmic degradation of fibrinogen modulates the activity and binding of FGF‐2 that involves a site near the carboxyl terminus of the γ chain.
Serotype 19A Bacteremic Pneumococcal Pneumonia After 4 Doses of 13-Valent Conjugate Vaccine

We report a case of bacteremic pneumococcal pneumonia due to serotype 19A in a child who had received four doses of the 13-valent pneumococcal conjugate vaccine, and review the literature on effectiveness of this vaccine. Pediatricians should be alert to the fact that up-to-date immunization status with pneumococcal vaccine does not preclude illness from invasive disease caused by a vaccine serotype.
Gastric Stromal Tumors: A Clinicopathologic Study of 77 Cases With Correlation of Features With Nonaggressive and Aggressive Clinical Behaviors

Gastrointestinal stromal tumors are a heterogeneous group of neoplasms that have clinical and histologic features that vary depending on their location within the gastrointestinal tract. Prediction of clinical behavior in this group of tumors is notoriously difficult, and the same criteria for malignancy do not necessarily apply to stromal tumors from different sites within the gastrointestinal tract. Using known clinical behavior with long-term follow-up, we attempted to determine which features, if any, are associated with clinical behavior in stromal tumors arising in the stomach, the most common site for such tumors. Seventy-seven gastric stromal tumors were studied and classified as “adverse outcome (AO) tumors” (malignant) or “nonadverse outcome tumors” (benign) based on their known clinical outcome. AO was defined as metastasis and/or death due to tumor. Patients with a non-AO had at least 5 years of tumor/metastasis-free follow-up. Thirty-seven patients had an AO (follow-up [metastasis at presentation] 0–73 months; median 6 months), and 40 patients had a non-AO (follow-up 60–264 months; median 84 months). All cases were reviewed by two authors (J.R.G., H.D.A.), who were blinded to clinical outcome and gross features, and classified as histologically benign or not benign using preset, defined histologic criteria based upon the authors' prior experience with a large number of these tumors. If the tumor did not fit with either the characteristic cellular spindle cell or benign epithelioid cell patterns, the tumor was classified as not benign. Clinical outcome was then correlated with the histologic designation to determine if these preset criteria were valid. The authors were able to accurately classify the tumors as benign or not benign with a sensitivity of 100% and a specificity of 92%. In addition, for all cases individual morphologic and clinical features were examined. Features associated with an AO included tumor size ≥7 cm, high cellularity, mucosal invasion, high nuclear grade, mitotic counts ≥5/50 high power fields, mixed cell type, and the presence of a myxoid background and/or absence of stromal hyalinization. By recognizing several well-defined patterns of benign gastric stromal tumors and the myriad of individual features shown to correlate with an AO, one can better predict the clinical behavior of gastric stromal tumors.
Chemotherapy of gestational choriocarcinoma

HE C O M P L E T E REGRESSION OF METASTATIC T< qestational choriocarcinoma treated with metliotrexate, first reported by Li et a1. ,2‘; in 1956, remains a source of encouragement to all chemotherapists. Of the first three patients treated at the N.I. H. , two are still alive today and have received no chemotherapy for 15 years.I3 These alone would seem to justify the title of this session, “Cancers in Which Some Patients Are Currently Achieving Normal Life Expectancy with Chemotherapeutic Agents. ” Fortunately, such responses are not unusual today. When proper chemotherapy is given carefully, nearly all women with metastatic gestational clioriocarcinoma or other related neoplasms arising in the placenta can be cured. For purposes of organization, this presentation will consider briefly the reasons for tlie steady improvement in response rates antl then give the evidence that these complete remission rates, based on measurement of gonadotropins, are likely to result in permanent cure. The utilization of chemotherapy in treating nonmetastatic trophoblastic diseases will also be discussed. The importance of sensitive and reliable gonadotropin assays will be reviewed and then tlie question of why treatment of these tumors has been so successful will be considered. Because untreated patients with metastatic gestational choriocarcinoma usually died within a year,*5 the results which Li et al. achieved by treating these women with methotrexate were quickly recognized as ushering in a new era in chemotherapy. In 1961, after 5 years’ experience, Hertz ,et a1.14 reported 47y0 complete and sustained remission rate in 63 women with metastatic disease. All but two of the patients in complete remission received only metliotrexate. In two others, Vincaleu-
Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins.

Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by loss of spinal motor neurons. The gene encoding the survival of motor neurons (SMN) protein is mutated in >95% of SMA cases. SMN is the central component of a large oligomeric complex, including Gemins2-7, that is necessary and sufficient for the in vivo assembly of Sm proteins onto the small nuclear (sn)RNAs that mediate pre-mRNA splicing. After cytoplasmic assembly of the Sm core, both SMN and splicing snRNPs are imported into the nucleus, accumulating in Cajal bodies for additional snRNA maturation steps before targeting to splicing factor compartments known as "speckles. " In this study, we analyzed the function of individual SMN complex members by RNA interference (RNAi). RNAi-mediated knockdown of SMN, Gemin2, Gemin3, and Gemin4 each disrupted Sm core assembly, whereas knockdown of Gemin5 and Snurportin1 had no effect. Assembly activity was rescued by expression of a GFP-SMN construct that is refractive to RNAi but not by similar constructs that contain SMA patient-derived mutations. Our results also demonstrate that Cajal body homeostasis requires SMN and ongoing snRNP biogenesis. Perturbation of SMN function results in disassembly of Cajal bodies and relocalization of the marker protein, coilin, to nucleoli. Moreover, in SMN-deficient cells, newly synthesized SmB proteins fail to associate with U2 snRNA or accumulate in Cajal bodies. Collectively, our results identify a previously uncharacterized function for Gemin3 and Gemin4 in Sm core assembly and correlate the activity of this pathway with SMA.
A New Joinless Apriori Algorithm for Mining Association Rules

In this paper, we introduce a new approach to implementing the apriori algorithm in association rule mining. We show that by omitting the join step in the classical apriori algoritm, and applying the apriori property to each transaction in the transactions database, we get the same results. We use a simulation study to compare the performances of the classical to the joinless algorithm under varying conditions and draw the following conclusions: (1) the joinless algorithm offers better space management; (2) the joinless apriori algorithm is faster for small, but slower for large, average transaction widths. We analyze the two algorithms to determine factors responsible for their relative performances. The new approach is demonstrated with an application to web mining of navigation sequences.
Testing and validation of a multi-sensor distributed surveillance system

The single location surveillance point (SLSP) is a distributed indoor multi-sensor surveillance system. It incorporates an arbitrary amount of sensors that collect data from a single location, which is the surveillance point. Each sensor collects information from its ambit. Once the crude data has been acquired from the sensors and transmitted to logical decision making server (LDMS) by the session server, the LDMS automatically performs logical deductions based on the data received from the sensors. The LDMS transmits the logical deductions to the human security administrator of the security manager server and/or the end-devices of the nomadic guards. Complicated surveillance systems possess rigid requirements regarding testing and validation. The main endeavor in testing and validating the SLSP system comprised of utilizing an adequate testing and validation process accompanied with sufficient tools to test the SLSP system. The testing and validation process is explained and testing is executed by utilizing two tools. The TCR (test case runner) tool was specifically built for the testing purposes of the SLSP system. A proprietary tool, Nethawk's EAST (environment for automated systems testing) IMS (IP (Internet protocol) multimedia subsystem) simulator, was utilized in testing. The operability of the constructed prototype accompanied with its successful testing and validation indicates that this endeavor is attained. The paper presents the testing and validation procedure, accompanied with the depiction of the testing tools and their utilization. The research is based on the constructive method of the related publications and technologies and the results are derived through testing and validating the implemented SLSP system.
Systems medicine: a real approach for future personalized oncology?

Current and emerging biomedical science efforts are driven by determining how to improve clinical outcomes for patients, but the roadmap to achieve this goal has been controversial. More than standard medicine, systems medicine attracts increasing research interest for some sophisticated diseases such as cancer because it might lead to improved clinical results more quickly and efficiently. High-throughput technology has revolutionized the area of translational research, confirming the high complexity and heterogeneity of common diseases, particularly cancer. Therefore, moving from ‘classic’ single-gene-based molecular investigation to molecular network research might result in discovering clinical implications faster and more efficiently [1–3]. The greatest challenge yet, however, is how to integrate molecular engineering and computing to predict complex systems inference, such as tumorigenesis and metastasis. As the cost of reading and writing DNA in the last decade has dropped 1 million-fold and high-quality oncological outcomes data (recurrence-death vs survival) has become available, efforts are focused on how, when using reverse engineering from clinical data, to discover the underlying key DNA changes, and to understand the functions and interactions responsible for phenotypic heterogeneity (treatment response/cure versus drug resistance/death) [4]. Here we explore the perspectives of the systems approach for the development of molecular network based cancer targets [4], and challenges to their translation into future day-to-day clinical practice. The emerging evidence is conclusive and leaves no room for debate. Cancer initiation, growth and metastasis are far more sophisticated biological processes than we thought. Indeed, extensive genetic studies [5,6] and next-generation DNA sequencing technology-based whole-cancergenome sequencing studies [7] on lung and breast cancer, and for the first time, melanoma [8–11], confirm the high complexity and hetero geneity of cancer. These findings allow modest optimism regarding the efficiency of the present generation of biologic drugs, despite some controversy over responsiveness in advanced disease. For the vast majority of biologics, the goal of targeting just one single component (mutated gene) or an entire signaling pathway, has had modest practical success. Indeed, the results of clinical trials in the metastatic setting have demonstrated either no survival prolongation or only a progression-free survival (PFS) improvement with no significant benefit in overall survival (OS) [4]. Successful translation of biologics from the metastatic setting to the adjuvant setting has been demonstrated only for trastuzumab in patients with hEGF receptor type 2 (HER2) early-stage breast cancer. However, even here longer followup results are required to assess whether targeted agents simply have a recurrence-delaying effect or if they can result in a true cure.
Interleaved Soft-Switching Boost Converter for Photovoltaic Power-Generation System

In this paper, a interleaved soft switching boost converter (ISSBC) for a photovoltaic (PV) power-generation system is proposed. The topology used raises the efficiency for the dc/dc converter of the PV power conditioning system (PVPCS), and it minimizes switching losses by adopting a resonant soft-switching method. A detailed mode analysis of the proposed topology is presented. The feasibility of the proposed topology is experimentally verified for a 1.2-kW prototype. The experimental results imply that 97.28% efficiency is achieved under the full-load condition. Consequently, it is confirmed that the overall efficiency is increased by about 1.5% compared with the conventional hard switching interleaved boost converter.