Miracle-dz/UniFAR-FTUs huggingface dataset:
Chipless-RFID: A Review and Recent Developments

In this paper, a review of the state-of-the-art chipless radiofrequency identification (RFID) technology is carried out. This recent technology may provide low cost tags as long as these tags are not equipped with application specific integrated circuits (ASICs). Nevertheless, chipless-RFID presents a series of technological challenges that have been addressed by different research groups in the last decade. One of these challenges is to increase the data storage capacity of tags, in order to be competitive with optical barcodes, or even with chip-based RFID tags. Thus, the main aim of this paper is to properly clarify the advantages and disadvantages of chipless-RFID technology. Moreover, since the coding information is an important aspect in such technology, the different coding techniques, as well as the main figures of merit used to compare different chipless-RFID tags, will be analyzed.
Cardiac Cx43 and ECM Responses to Altered Thyroid Status Are Blunted in Spontaneously Hypertensive versus Normotensive Rats

Heart function and its susceptibility to arrhythmias are modulated by thyroid hormones (THs) but the responsiveness of hypertensive individuals to thyroid dysfunction is elusive. We aimed to explore the effect of altered thyroid status on crucial factors affecting synchronized heart function, i.e., connexin-43 (Cx43) and extracellular matrix proteins (ECM), in spontaneously hypertensive rats (SHRs) compared to normotensive Wistar Kyoto rats (WKRs). Basal levels of circulating THs were similar in both strains. Hyperthyroid state (HT) was induced by injection of T3 (0.15 mg/kg b.w. for eight weeks) and hypothyroid state (HY) by the administration of methimazol (0.05% for eight weeks). The possible benefit of omega-3 polyunsaturated fatty acids (Omacor, 200 mg/kg for eight weeks) intake was examined as well. Reduced levels of Cx43 in SHRs were unaffected by alterations in THs, unlike WKRs, in which levels of Cx43 and its phosphorylated form at serine368 were decreased in the HT state and increased in the HY state. This specific Cx43 phosphorylation, attributed to enhanced protein kinase C-epsilon signaling, was also increased in HY SHRs. Altered thyroid status did not show significant differences in markers of ECM or collagen deposition in SHRs. WKRs exhibited a decrease in levels of profibrotic transforming growth factor β1 and SMAD2/3 in HT and an increase in HY, along with enhanced interstitial collagen. Short-term intake of omega-3 polyunsaturated fatty acids did not affect any targeted proteins significantly. Key findings suggest that myocardial Cx43 and ECM responses to altered thyroid status are blunted in SHRs compared to WKRs. However, enhanced phosphorylation of Cx43 at serine368 in hypothyroid SHRs might be associated with preservation of intercellular coupling and alleviation of the propensity of the heart to malignant arrhythmias.
Antenatal infection and intraventricular hemorrhage in preterm infants

Abstract Background: The aim of this study was to summarize current evidence evaluating the association between antenatal infection and intraventricular hemorrhage (IVH) in preterm infants. Materials and methods: We searched for published articles on antenatal infection and IVH in 3 English (PubMed, the Cochrane Library, and EBSCO) and 3 Chinese (VEIPU, CNKI, and WANFANG) databases on May 19, 2019. In addition, the references of these articles were screened. The included studies had to meet all of the following criteria: preterm infants (<37 weeks); comparing antenatal infection with no infection; the outcomes included IVH (all grades), mild IVH, or sereve IVH; the type of study was randomized controlled trial or cohort study. Results: A total of 23 cohort studies involving 13,605 preterm infants met our inclusion criteria. Antenatal infection increased the risk of IVH (odds ratios ([OR] 2.18, 95% confidence intervals [CI] 1.58–2.99), mild IVH (OR 1.95, 95% CI 1.09–3.49) and severe IVH (OR 2.65, 95% CI 1.52–4.61). For type of antenatal infection, the ORs and 95% CI were as follows: 2.21 (1.60–3.05) for chorioamnionitis, 2.26 (1.55–3.28) for histologic chorioamnionitis, 1.88 (1.22–2.92) for clinical chorioamnionitis, and 1.88 (1.14–3.10) for ureaplasma. Conclusions: Antenatal infection may increase the risk of developing IVH in the preterm infant. The evidence base is however of low quality and well-designed studies are needed.
A Review on The Protective Effects of Metformin in Sepsis-Induced Organ Failure

Despite advances in sepsis management, it remains a major intensive-care-unit (ICU) concern. From new prospective, positive effects of metformin, such as anti-oxidant and anti-inflammatory properties are considered potentially beneficial properties for management of septic patients. This article reviewed the potential ameliorative effects of metformin in sepsis-induced organ failure. Information were retrieved from PubMed, Scopus, Embase, and Google Scholar. Multi-organ damage, oxidative stress, inflammatory cytokine stimulation, and altered circulation are hallmarks of sepsis. Metformin exerts its effect via adenosine monophosphate-activated protein kinase (AMPK) activation. It improves sepsis-induced organ failure by inhibiting the production of reactive oxygen species (ROS) and pro-inflammatory cytokines, preventing the activation of transcription factors related to inflammation, decreasing neutrophil accumulation/infiltration, and also maintaining mitochondrial membrane potential. Studies reported the safety of metformin therapeutic doses, with no evidence of lactic acidosis, in septic patients.
Assessment of protein assembly prediction in CASP13

We present the assembly category assessment in the 13th edition of the CASP community‐wide experiment. For the second time, protein assemblies constitute an independent assessment category. Compared to the last edition we see a clear uptake in participation, more oligomeric targets released, and consistent, albeit modest, improvement of the predictions quality. Looking at the tertiary structure predictions, we observe that ignoring the oligomeric state of the targets hinders modeling success. We also note that some contact prediction groups successfully predicted homomeric interfacial contacts, though it appears that these predictions were not used for assembly modeling. Homology modeling with sizeable human intervention appears to form the basis of the assembly prediction techniques in this round of CASP. Future developments should see more integrated approaches where subunits are modeled in the context of the assemblies they form.
Effect of Onset Threshold on Kinetic and Kinematic Variables of a Weightlifting Derivative Containing a First and Second Pull.

James, LP, Suchomel, TJ, McMahon, JJ, Chavda, S, and Comfort, P. Effect of onset threshold on kinetic and kinematic variables of a weightlifting derivative containing a first and second pull. J Strength Cond Res XX(X): 000-000, 2019-This study sought to determine the effect of different movement onset thresholds on both the reliability and absolute values of performance variables during a weightlifting derivative containing both a first and second pull. Fourteen men (age: 25.21 ± 4.14 years; body mass: 81.1 ± 11.4 kg; and 1 repetition maximum [1RM] power clean: 1.0 ± 0.2 kg·kg) participated in this study. Subjects performed the snatch-grip pull with 70% of their power clean 1RM, commencing from the mid-shank, while isolated on a force platform. Two trials were performed enabling within-session reliability of dependent variables to be determined. Three onset methods were used to identify the initiation of the lift (5% above system weight [SW], the first sample above SW, or 10 N above SW), from which a series of variables were extracted. The first peak phase peak force and all second peak phase kinetic variables were unaffected by the method of determining movement onset; however, several remaining second peak phase variables were significantly different between methods. First peak phase peak force and average force achieved excellent reliability regardless of the onset method used (coefficient of variation [CV] < 5%; intraclass correlation coefficient [ICC] > 0.90). Similarly, during the second peak phase, peak force, average force, and peak velocity achieved either excellent or acceptable reliability (CV < 10%; ICC > 0.80) in all 3 onset conditions. The reliability was generally reduced to unacceptable levels at the first sample and 10 N method across all first peak measures except peak force. When analyzing a weightlifting derivative containing both a first and second pull, the 5% method is recommended as the preferred option of those investigated.
Inactivated Rabies Virus-Based Ebola Vaccine Preserved by Vaporization Is Heat-Stable and Immunogenic Against Ebola and Protects Against Rabies Challenge.

BACKGROUND Ebola virus (EBOV) is a highly lethal member of the Filoviridae family associated with human hemorrhagic disease. Despite being a sporadic disease, it caused a large outbreak in 2014-2016 in West Africa and another outbreak recently in the Democratic Republic of Congo. Several vaccine candidates are currently in preclinical and clinical studies but none are stable without cold chain storage. METHODS We used preservation by vaporization (PBV), a novel processing technology to heat-stabilize FiloRab1 (inactivated rabies-based Ebola vaccine), a candidate Ebola vaccine, and stored the vials at temperatures ranging from 4°C to 50°C for 10 days to 12 months. We immunized Syrian hamsters with the best long-term stable FiloRab1 PBV vaccines and challenged them with rabies virus (RABV). RESULTS Syrian hamsters immunized with FiloRab1 PBV-processed vaccines stored at temperatures of 4°C and 37°C for 6 months, and at 50°C for 2 weeks, seroconverted against both RABV-G and EBOV-GP. Notably, all of the FiloRab1 PBV vaccines proved to be 100% effective in a RABV challenge model. CONCLUSIONS We successfully demonstrated that the FiloRab1 PBV vaccines are stable and efficacious for up to 6 months when stored at temperatures ranging from 4°C to 37°C and for up to 2 weeks at 50°C.
Sprouty3 and Sprouty4, Two Members of a Family Known to Inhibit FGF-Mediated Signaling, Exert Opposing Roles on Proliferation and Migration of Glioblastoma-Derived Cells

Dysregulation of receptor tyrosine kinase-induced pathways is a critical step driving the oncogenic potential of brain cancer. In this study, we investigated the role of two members of the Sprouty (Spry) family in brain cancer-derived cell lines. Using immunoblot analyses we found essential differences in the pattern of endogenous Spry3 and Spry4 expression. While Spry4 expression was mitogen-dependent and repressed in a number of cells from higher malignant brain cancers, Spry3 levels neither fluctuated in response to serum withdrawal nor were repressed in glioblastoma (GBM)-derived cell lines. In accordance to the well-known inhibitory role of Spry proteins in fibroblast growth factor (FGF)-mediated signaling, both Spry proteins were able to interfere with FGF-induced activation of the MAPK pathway although to a different extent. In response to serum solely, Spry4 exerts its role as a negative regulator of MAPK activation. Ectopic expression of Spry4 inhibited proliferation and migration of GBM-originated cells, positioning it as a tumor suppressor in brain cancer. In contrast, elevated Spry3 levels accelerated both proliferation and migration of these cell lines, while repression of Spry3 levels using shRNA caused a significant diminished growth and migration velocity rate of a GBM-derived cell line. This argues for a tumor-promoting function of Spry3 in GBMs. Based on these data we conclude that Spry3 and Spry4 fulfill different if not opposing roles within the cancerogenesis of brain malignancies.
Chondroitin Sulfate-Linked Prodrug Nanoparticles Target the Golgi Apparatus for Cancer Metastasis Treatment.

Metastasis is a multistep biological process regulated by multiple signaling pathways. The integrity of the Golgi apparatus plays an important role in these signaling pathways. Inspired by the mechanism and our previous finding about accumulation of chondroitin sulfate in Golgi apparatus in hepatic stellate cells, we developed a Golgi apparatus-targeting prodrug nanoparticle system by synthesizing retinoic acid (RA)-conjugated chondroitin sulfate (CS) (CS-RA). The prodrug nanoparticles appeared to accumulate in the Golgi apparatus in cancer cells and realized RA release under the acidic environment. We confirmed that CS-RA exhibited successful inhibition of multiple metastasis-associated proteins expression in vitro and in vivo by disruption of the Golgi apparatus structure. Following loading with paclitaxel (PTX), the CS-RA based nanoformulation (PTX-CS-RA) inhibited migration, invasion and angiogenesis in vitro, suppressed tumor growth and metastasis in 4T1-Luc bearing mice. This multistep targeted nanoparticle system potentially enhanced the effect of anti-metastasis combined with chemotherapy.
Transcranial Direct Current Stimulation Does Not Improve Countermovement Jump Performance in Young Healthy Men

Abstract Romero-Arenas, S, Calderón-Nadal, G, Alix-Fages, C, Jerez-Martínez, A, Colomer-Poveda, D, and Márquez, G. Transcranial direct current stimulation does not improve countermovement jump performance in young healthy men. J Strength Cond Res 35(10): 2918–2921, 2021—The main purpose of this study was to report the effects of transcranial direct current stimulation (tDCS) on countermovement jump (CMJ) performance in young healthy men. Seventeen healthy male subjects volunteered for the study (age: 22.4 ± 2.6 years; body mass: 71.8 ± 8.7 kg; height: 174.6 ± 5.9 cm; and CMJ height: 36.8 ± 6.3 cm). After a familiarization session, subjects underwent 3 experimental conditions, 7 days apart, in a randomized, double-blinded crossover design: anodal, cathodal, and sham tDCS. The stimulation was applied over the dorsolateral prefrontal cortex for 15 minutes. During experimental sessions, subjects completed a warm-up and 3 CMJ trials separated by 1 minute before and after each of the 3 experimental conditions. Countermovement jump height and muscular peak power were extracted from the best CMJ in each moment. A 2-way repeated-measures analysis of variance with time and condition as factors were performed for CMJ height and muscular peak power. Effect size analysis was conducted using Cohen's d coefficient. The analysis did not show either significant main effects or interactions for both time and condition factors in the CMJ performance (p > 0.05). Furthermore, effect size was trivial for all conditions (d: 0.01–0.14) in CMJ height and muscular peak power. These findings suggest that tDCS may not be a valuable tool to improve vertical jump performance.
Rescheduling Part 2 of the 11+ reduces injury burden and increases compliance in semi‐professional football

Although the 11+ program has been shown to reduce injuries in sub‐elite football, program compliance is typically poor, suggesting that strategies to optimize delivery are necessary. This study investigated the effect of rescheduling Part 2 of the three‐part 11+ program on program effectiveness. Twenty‐five semi‐professional football clubs were randomly allocated to either a Standard‐11+ (n = 398 players) or P2post group (n = 408 players). Both groups performed the 11+ program at least twice a week throughout the 2017 football season. The Standard‐11+ group performed the entire 11+ program before training activities commenced, whereas the P2post group performed Parts 1 and 3 of the 11+ program before and Part 2 after training. Injuries, exposure, and individual player 11+ dose were monitored throughout the season. No significant between group difference in injury incidence rate (P2post vs Standard‐11+ = 11.8 vs 12.3 injuries/1000 h) was observed. Severe time loss injuries > 28 days (33 vs 58 injuries; P < .002) and total days lost to injury (4303 vs 5815 days; P < .001) were lower in the P2post group. A higher 11+ program dose was observed in the P2post (29.1 doses; 95% CI 27.9‐30.1) versus Standard‐11+ group (18.9 doses; 95% CI 17.6−20.2; P < .001). In semi‐professional football, rescheduling Part 2 of the 11+ program to the end of training maintained the effectiveness of the original 11+ program to reduce injury incidence. Importantly, rescheduling Part 2 improved player compliance and reduced the number of severe injuries and total injury burden, thereby enhancing effectiveness of the 11+ program.
Acetic acid bacteria encode two levansucrase types of different ecological relationship.

Acetic acid bacteria (AAB) are associated with plants and insects. Determinants for the targeting and occupation of these widely different environments are unknown. However, most of these natural habitats share plant-derived sucrose, which can be metabolized by some AAB via polyfructose building levansucrases (LS) known to be involved in biofilm formation. Here, we propose two LS types (T) encoded by AAB as determinants for habitat selection, which emerged from vertical (T1) and horizontal (T2) lines of evolution and differ in their genetic organization, structural features and secretion mechanism, as well as their occurrence in proteobacteria. T1-LS are secreted by plant-pathogenic α- and γ-proteobacteria, while T2-LS genes are common in diazotrophic, plant-growth promoting α-, β- and γ-proteobacteria. This knowledge may be exploited for a better understanding of microbial ecology, plant health and biofilm formation by sucrase-secreting proteobacteria in eukaryotic hosts. This article is protected by copyright. All rights reserved.
Research Progress on Long Non-Coding RNA and Radiotherapy

Long non-coding RNAs (lncRNAs), a group of non-protein-coding RNAs longer than 200 nucleotides, are involved in multiple biological and pathological processes, such as proliferation, apoptosis, migration, invasion, angiogenesis, and immune escape. Many studies have shown that lncRNAs participate in the complex network of cancer and play vital roles as oncogenes or tumor-suppressor genes in a variety of cancers. Moreover, recent research has shown that abnormal expression of lncRNAs in malignant tumor cells before and after radiotherapy may participate in the progression of cancers and affect the radiation sensitivity of malignant tumor cells mediated by specific signaling pathways or cell cycle regulation. In this review, we summarize the published studies on lncRNAs in radiotherapy regarding the biological function and mechanism of human cancers, including esophageal cancer, pancreatic cancers, nasopharyngeal carcinoma, hepatocellular carcinoma, cervical cancer, colorectal cancer, and gastric cancer.
A REAL-TIME ATTITUDE ESTIMATION SCHEME FOR HEXAROTOR MIC RO AERIAL VEHICLE

Abstract. Position and attitude estimation is vital for vertical take-off and landing unmanned aerial vehicle ( VTOL-UAV) that can be executed by integrating the output of gyros, accelerometers and magnetometers with respectively gravity and local magnetic field vectors. For this purpose, a Kalman filter with different variant as extended, unscented and complementary has been largely used in the literature. Another technique, vision data to navigate an unknown, indoor, GPS-denied environment with optical flow or visual servo based on image or position was used. Without external sensing, an estimation system that relies only on integrating inertial data will have rapidly drifting position estimates. VTOL-UAVs are stringently weight constrained, leaving little margin for additional sensors beyond the mission payload. The aim of this paper is to present a realtime sensor fusion scheme based on nonlinear filtering, for hexarotor UAV to localization problem. The absolute attitude estimation use the extended Kalman filter based on quaternion to avoid singularities. Results obtained in realtime system to the hexarotor UAV shows the better attitude performance.
ON THE USE OF LOW COST ADSORBENTS FOR THE REMOVAL OF ENDOCRINE DISRUPTORS FROM WATER : A CASE STUDY WITH BISPHENOL A

The present paper is focused on the use of low cost adsorbents for the removal of endocrine disruptors from water. This class of organic compounds has been recentlz considered of increasing environmental concern because of the adverse health effects. Among them, bisphenol A (BPA), widely used for the plastic production, is considered as a critical contaminant due to its harmful effects. The adsorption efficiencies of four types of activated carbons, commonly used in the drinking water treatment, on the bisphenol A removal were investigated using batch adsorption experiments. Based on kinetic and mass transfer considerations the activated carbon F400 gives the best results and was selected for further adsorption studies. The obtained results showed that the BPA isotherm experimental data are well described by Freundlich isotherm and demonstrated the excellent performance of the selected adsorbent. Thus, F400 can be considered of a potential practical interest for the BPA pollution control purposes.
PREDOMINANT QUALITY ATTRIBUTES IN EVALUATING SOFTWARE ARCHITECTURE AND ADDRESSING SCENARIO COVERAGE PROBLEM

The quality of the software is measured primarily against the degree to which user requirements, such as correctness, reliability and usability are met. The use of a well defined model of the software development process and good analysis, design and implementation techniques are prerequisite to ensuring quality. Software Quality Attributes are the benchmarks that describe system’s intended behavior within the environment for which it was built. The quality attributes provide the means for measuring the fitness and suitability of a product. Essential quality attributes need to be characterized in a system-specific way. Most of the Software architecture evaluation methods were not addressing the essential quality attributes. This paper present a report collected from large software firms which gives set quality attributes playing a vital role in getting quality software.