Miracle-dz/UniFAR-FTUs huggingface dataset:
A comparative study of novel biomarkers on preeclampsia in relation to body mass index

Sabir Ali Shaikh*1, Rajagopalan Vijayaraghavan2, Das Subir Kumar1, Pal Manidip3 1Department of Biochemistry, College of Medicine and JNM Hospital, West Bengal University of Health Sciences, Kalyani, Nadia, 741235, India 2Saveetha Institute of Medical and Technical Sciences, Saveetha University, Thandalam, Chennai, 602105, Tamil Nadu, India 3Department of Obstetrics and Gynaecology, College of Medicine and JNM Hospital, West Bengal University of Health Sciences, Kalyani, Nadia, 741235, India
Transverse localization of light in laser written designed disorder

Transverse Anderson localization provides the lateral confinement of electromagnetic waves in disordered systems that are invariant along the propagation direction. Here, we demonstrate a disorder induced confinement in glass microstructures where disorder is fabricated ad hoc by the femtosecond direct laser writing technique. By employing a high numerical aperture objective, we are able to write parallel arrays of tiny tubes with a refractive index higher than the surrounding glass and to arrange them in a disordered fashion in the transversal plane. We demonstrate that these paraxial scatterers are supporting transverse localization and that the confinement strength depends on the disorder properties. The proposed approach, which relies on a user-controlled positioning of individual scatterers, allows us to finely tune the structural design, maximizing the transversal confinement.
The Impact of Customer Concentration on the Tunneling of the Large Shareholders

With the increasing concentration of the shareholding, the tunneling of the large shareholders has gradually become a hot topic in the field of corporate governance, which is a problem that is common in China’s listed companies and needs to be solved urgently. This paper applies the supervisory role of stakeholders to corporate governance. Based on the research sample of non-financial listed companies in China from 2010 to 2017, we empirically examined the impact of customer concentration on the tunneling of the large shareholders. The research results show that the higher the concentration of customers, the lower the possibility of large shareholders’ tunneling; the cash holdings have an intermediary role in the relationship between customer concentration and the tunneling of large shareholders; compared with those with low market position. The negative correlation between customer concentration and the tunneling of large shareholders is more pronounced in companies with high market positions. The conclusions of this paper are not only conducive to further understanding the corporate governance role of stakeholders, but also help to improve the corporate governance and protect the interests of investors.
Macroecology and macroevolution of body size inAnolislizards

812 –––––––––––––––––––––––––––––––––––––––– © 2020 The Authors. Ecography published by John Wiley & Sons Ltd on behalf of Nordic Society Oikos This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Subject Editor: Ken Kozak Editor-in-Chief: Miguel Araújo Accepted 15 January 2020 43: 812–822, 2020 doi: 10.1111/ecog.04583 43 812–822
Impact of Optimized Protein in Infant Formula on the Metabolic and Nutritional Health in Infants: Systematic Review with Meta-Analysis

Background. Increasing evidence demonstrate that concentration of protein in infant formula >1.9g/100Kcal with high levels of insulinogenic aminoacids is associated with accelerated weight gain, increased fat mass accumulation and risk of adiposity. Purpose of this study was to conduct a systematic review to determine the metabolic effects in infants feed with infant formula optimized in protein. Methods. Systematic review was conducted according PRISMA Statement. RCTs with one intervention group (infant formula with 1.6-1.9gr of protein/100Kcal) and at least one comparative control group (infant formula with >1.9gr of protein/100Kcal) were included. Standardized mean differences (SMD), through random model were calculated. Results. 15 RCT were included. Optimized protein in infant formula was associated with less gain of BMI at 24 months of follow-up (SMD -0.25, IC95% -0.36 to -0.13, p 0.01) and less fat mass accumulation (SMD -0.68, IC95% -0.98 to -0.37, p 0.01). Optimized protein was also associated to less gain of weight, weight/age Z-score, weight/length Z-score, BUN (mmol/dL) and IGF−1 (ng/ml). No effect on length/age Z-score was observed. Conclusions. Robust evidence showed optimized protein (1.6gr/100Kcal to 1.9gr/100Kcal) in infant formula is associated with metabolic benefits in infants with less weight gain, BMI and fat mass accumulation.
Current therapy and new drugs: a road to personalized treatment of myelodysplastic syndromes

ABSTRACT Introduction: An accurate diagnostic and prognostic evaluation of patients with myelodysplastic syndromes (MDS) is essential: treatments are different for patients at lower or higher risk of evolution into acute myeloid leukemia (AML). Molecular data are more and more important: gene mutations or microRNA profiling can be used to better stratify MDS patients and address them to a personalized therapeutic approach. Areas covered: This review focuses on the European MDS diagnosis, prognosis and therapy. The authors, stemming from literature and published data, discuss and describe the current state-of-the art of MDS, focusing on conventional tools, such as morphology and cytogenetics, but also illustrating new molecular data and how targeting these molecules could be important to develop innovative therapeutic approaches. Expert commentary: Currently, MDS treatments include supportive therapies, iron chelation and erythroid-stimulating agents (ESAs) for lower-risk MDS, Lenalidomide for del(5q) MDS, hypomethylating agents (HMAs) and allogeneic stem cell transplantation (SCT) for higher risk patients. Molecular analyses are acquiring great relevance in MDS diagnosis, prognosis and therapy. Interestingly, PI-PLCbeta1 regulates hematopoietic differentiation, is a predictive marker of response to azacitidine and could be an ideal target for drug design, aiming to regulate MDS pathogenesis and prevent MDS progression to AML.
Phonon energy dissipation in friction between graphene/graphene interface

The theory of phononic friction attributes that the multiphonon processes are the main cause of the mechanical energy dissipation in a wear-free friction process. Unfortunately, it is still impossible to set up a direct relationship between the phonons and the frictional force. In this study, a classical molecular dynamics simulation model is used to mimic a piece of graphene sliding over a supported graphene substrate. It is found that the lifetime of some phonons, especially the modes around the Γ point of the first Brillouin zone, gradually decreases with the increase of the sliding velocity. A phonon lifetime-based model is proposed to explain the variation of the frictional force as a function of the sliding velocity, i.e., the shorter phonon lifetime corresponding to a higher friction force under the same temperature. This model is consistent with the traditional Prandtl-Tomlinson model at a low sliding velocity range, which predicts that the friction force increases logarithmically with the sliding velocity. Once the sliding velocity exceeds a critical value, the lifetime of the excited phonons is far longer than the time for the tip sweeping a lattice constant. In this case, the excited phonons do not have enough time to dissipate the mechanical energy, which leads to the reduced friction force with the increase of the sliding velocity.The theory of phononic friction attributes that the multiphonon processes are the main cause of the mechanical energy dissipation in a wear-free friction process. Unfortunately, it is still impossible to set up a direct relationship between the phonons and the frictional force. In this study, a classical molecular dynamics simulation model is used to mimic a piece of graphene sliding over a supported graphene substrate. It is found that the lifetime of some phonons, especially the modes around the Γ point of the first Brillouin zone, gradually decreases with the increase of the sliding velocity. A phonon lifetime-based model is proposed to explain the variation of the frictional force as a function of the sliding velocity, i.e., the shorter phonon lifetime corresponding to a higher friction force under the same temperature. This model is consistent with the traditional Prandtl-Tomlinson model at a low sliding velocity range, which predicts that the friction force increases logarithmically with the sliding.
Primary leiomyosarcoma of spleen masquerading adrenal tumor - A rare case

Leiomyosarcoma (LMS) is a malignant smooth muscle tumor which is predominantly intra-abdominal in location. LMS arising from vascular smooth muscle is quite uncommon which usually arises from inferior vena cava and is aggressive in nature. Primary venous LMS of splenic vein is exceedingly rare and has unpredictable clinical course with complete surgical resection representing the only potentially curative treatment. We hereby report a case of primary splenic vein LMS in a 59-year-old male patient mimicking an adrenal tumor radiologically.
Association of Immunoglobulin G at Birth with Late-Onset Sepsis and Related Mortality in Very Low Birth Weight Infants.

Purpose: We aimed to evaluate the association between immunoglobulin G (IgG) at birth and late-onset sepsis (LoS) in preterm infants. Methods: Medical records of very-low-birth-weight infants, born at gestational age <28 weeks, between 2013 and 2016, were retrospectively reviewed. Subjects were divided into two groups based on the occurrence of LoS (LoS vs. non-LoS), and IgG levels at 1 day, and at 2 weeks and 4 weeks after birth were investigated. IgG levels, other perinatal factors, and clinical factors were compared in the two groups. The relationship between IgG levels and mortality among infants in the LoS group was also analyzed. Results: A total of 105 infants were analyzed after exclusion of cases with early onset sepsis or death at <72 hours of life. Gestational age in the LoS group was lower than in the non-LoS group (25.0±1.8 vs. 26.3±1.4 weeks, P=0.004). IgG levels at birth were similar between the two groups (236.4±96.4 vs. 282.0±104.7 mg/dL, P=0.078). Multivariate analysis showed that IgG at birth was not an independent risk factor for LoS. In the LoS group, IgG levels at birth were comparable between survivors and cases involving mortality. Conclusion: IgG levels at birth were not associated with the occurrence of LoS in extremely preterm infants.
SLOVENE AND VOJVODINA RUSYN SONORANTS – A CONTRASTIVE ANALYSIS STUDY

The article discusses the similarities and differences between Slovene and Vojvodina Rusyn sonorants. Slovene and Vojvodina Rusyn sonorants are divided into two groups, vowels and consonantal sonorants, and analysed, i.e. described and compared, in terms of phoneme subinventories, allophones and their effect on voicing. With regard to sonorants, the contrastive phonemic analysis shows considerable differences between Slovene and Vojvodina Rusyn.
An Evaluation of Predictive Accuracy of Common Machine Learning Algorithms on Data Stream

Streamed data are a potentially infinite sequence of incoming data at every high speed and may evolve over real-time. This causes several challenges in large scale high-speed data streams in real-time applications. Hence, this field has gained a lot of attention from researchers in recent years. In recent times, there are several areas of human endeavors where data generated are periodical or constantly growing. For instance, capital market, social networks, metrological data, E-commerce, online gaming and betting platforms. This research implemented the common machine learning algorithm on data streams and random data sets to describe the kind of data with more accurate predictions. Data samples were obtained from social media platforms such as Twitter and Instagram within the periods of 4th to 15th February 2019 with a total of 510,738 data samples collected. This is due to the sheer size of these platforms. Random forest, multi-layer perceptron and the k-nearest neighbor algorithms were used to model the data streams using the WEKA and RapidMiner data mining programs. The result of the research shows that Multilayer Perceptron produced the highest level of accuracy in both programs used when compared to the other algorithms used in the research. The findings of this research will be relevant to other researchers willing to develop machine learning tools to test the accuracy of data streams on social media platforms and related fields.
Social science studies of the environment in Taiwan: what can the international community learn from work published within Taiwan?

ABSTRACT This Translations contribution synthesises critical environmental social science research produced in Taiwan and published largely in Chinese. Taiwan is distinctive in east Asia in that it has had, over several decades, a relatively large and prolific community of scholars engaged with environmental justice and sustainability. This research tradition is linked to the emergence of grassroots environmentalism in response to environmental issues faced during Taiwan’s rapid industrialisation, and to the democratisation of Taiwanese society from the 1980s onwards. Fuller understanding of research produced and published within in Taiwan hence yields insights for the role of social science within newly industrialising and democratising nations. Although the story of Taiwanese society’s relation to environmentalism is to an extent understood in English-language literature, less prevalent are the diverse ways Taiwanese social scientists have engaged with environmental issues, the empirical case studies which have shaped their thinking, and the influences of Western environmental sociology and science and technology studies (STS) within Taiwan. By synthesising Chinese-language environmental social science literature from Taiwan, we characterise three strands of scholarship: activism and social movements; environmental controversies; and environmental governance, policy and institutions. We identify (a) the ability of communities and civil societies to affect change from within extant governance processes and (b) the local-level implications of national sustainable development rhetoric as two areas where Taiwanese scholarship may make particularly valuable contributions to work at the sustainability-environmental justice interface.
Can We Use MDDScore for the Identification of Comorbid Major Depressive Disorder (MDD) in Patients with Chronic Pain

The prevalence of patients with chronic pain who display depressive symptoms is quite high, with depression potentially an integral component of chronic pain. Since the current subjective clinical diagnostic systems were not designed to assess depression in patients with chronic pain, they fail to adequately capture the nature of mood states of these patients. It is difficult to apply these assessment tools to segregate unipolar depression (MDD) from the demoralization inherent in chronic pain states. MDDScore™, a multivariate biomarker blood test for depression, was used to determine if it was possible to identify biomarker patterns consistent with major depressive disorder in multiple chronic pain states. Three study groups were analyzed, and included: (i) patients (n=93) with centralized Chronic Intractable Pain (CIP), (ii) patients (n=20) with chronic pain of diverse origin from Scripps Pain Clinic (SPC) and (iii) prospectively collected patients (n=28) with comorbid arthritis and depressive symptoms. A very distinct bimodal pattern was observed. Forty-nine of 93 CIP patients (52.7%), 18 of 28 (64.2%) of the arthritis patients, and 9 of 20 (45%) patients with chronic pain of diverse origin from Scripps Pain Clinic had MDDScores of ≥5. Thus, the biomarker panel could segregate patients into two major groups based upon MDDScores. These data suggest but not prove we can objectively identify chronic pain patients with a higher probability of comorbid major depression. Importantly, we can use the biomarkers on the MDDScore panel to gain insight into and gauge the residual (post-treatment) level of inflammation in these intensively treated patients. To this end, we determined and compared the serum concentrations of alpha-1 antitrypsin (A1AT), Myeloperoxidase (MPO) and soluble tumor necrosis factor receptor type 2 (sTNFR2) in each of the patient populations studied.
Research on Consumer Trust of Fresh Products in O2O Mode

With the wide application of Internet information technology, the E-marketing of fresh agricultural products has been developed rapidly. However, the current situation of small-scale agricultural economy in China determines that the fresh agricultural products are decentralized management, therefore, it is difficult for consumers to effectively obtain relevant product quality guarantees. Moreover, the capital flow and information flow of O2O platform transaction are in a high-risk environment, and there is network security problem. Based on this, this paper will make an empirical study on the influencing factors of consumer trust under the O2O mode, and put forward some suggestions for improving consumer trust.
Gastro-esophageal reflux-associated cough in children (reflux cough): up-to-date review

Chronic unexplained cough, defined as coughing for more than four weeks, is a frequent childhood symptom. Pediatric normal cough is a common complaint in 35% of preschool children and in 9% of 7-11-year-olds. Nevertheless, chronic non-specific cough has been reported to be associated with a variety of illnesses, including asthma, gastro-esophageal reflux (GER), post-nasal drip syndrome (PNDS), post-viral illness, and passive smoking. PNDS, asthma and GER account for > 90% of the likely etiologic factors of chronic cough in children and respond to appropriate treatment. Accordingly, GER is one of the three most common causes of chronic cough in all age groups. GER is known as a frequent and benign affection, especially during infancy. However, cough and GER are common ailments and their co-existence by chance is high. Cough also can induce reflux episodes. GER most likely causes chronic cough by stimulation of an esophageo- tracheo-bronchial reflex. Diagnosing GER-related cough is challenging since many patients do not have esophagitis or an increased esophageal acid exposure during 24-hour esophageal pHmetry. In interpreting this test, it is essential not only to evaluate the duration and frequency of the reflux episodes but also to determine the temporal relationship between reflux and cough events. In treating patients with chronic cough resulting from GER, cough has been reported to resolve with medical therapy 70-100% of the time. Treatment for GER includes conservative measures (diet and postural manipulation), pharmaceutical therapy such as prokinetic agents, H2-antagonists and proton pump inhibitors. If maximal medical therapy fails, anti-reflux surgery (fundoplication) can be successful.
Forecasting TB notifications at Zengeza clinic in Chitungwiza, Zimbabwe

This study uses monthly time series data on TB notifications at Zengeza clinic in Chitungwiza from January 2013 to December 2018; to forecast TB notifications using the Box & Jenkins (1970) approach to univariate time series analysis. Diagnostic tests indicate that TBN is an I (0) variable. Based on the AIC, the study presents the SARMA (2, 0, 2)(1, 0, 1)12 model, the diagnostic tests further show that this model is quite stable and hence acceptable for forecasting the TB notifications at Zengeza clinic. The selected optimal model shows that the TB notifications will decline over the out-of-sample period. The main policy recommendation emanating from this study is that there should be continued intensification of TB surveillance and control programmes in order to reduce TB incidences not only at Zengeza clinic but also in Zimbabwe at large.
Detection of Rotavirus and Adenovirus Co-infection among Apparently Healthy School Aged Children in Ilishan-remo Community of Ogun State, Nigeria

Background: Viral gastroenteritis is still a major public health challenge in the Sub-Sahara Africa, with Rotavirus and Adenovirus as the leading causes of acute gastroenteritis among children. Aim: The aim of this study was to investigate the prevalence of Rotavirus and Adenovirus co-infection and associated risk factors among apparently healthy school aged children with history of diarrhea in Ilishan-Remo community of Ogun State, Nigeria. Study Design: This is a descriptive-epidemiological survey. Place and Duration of Study: Department of Medical Laboratory Science, Babcock University, Ilishan-Remo, Ogun State, Nigeria, between March and May, 2019. Methodology: A total of 60 children (24 males and 36 females) were recruited and their stool samples were examined using the SD Bioline Rota/Adeno virus antigen rapid test kits (Standard Diagnostics, INC., South-Korea) according to the manufacturer’s instruction. The demographic and clinical information of the participants were collected using structured questionnaires. Results: Three, 3 (5.0%) out of the 60 participants screened, were mono-infected with Rotavirus, 2 (3.3%) were mono-infected with Adenovirus, while only 1 (1.7%) of them was co-infected with both Rotavirus and Adenovirus. There were no significant differences (P>0.05) in the prevalence of mono/co-infection with Rotavirus and Adenovirus among the study participants on the basis of age and gender. Lack of knowledge of Rotavirus and Adenovirus, history of diarrhea, eating of raw unwashed fruits and vegetables, poor hand hygiene after playing with toys and peers, and lack of regular medical check-up are some of the risk factors identified in this study. Conclusion: The outcome of this study shows that mono/co-infection with Rotavirus and Adenovirus exist among apparently healthy school aged children with history of diarrhea in Ilishan-Remo community of Ogun State, Nigeria with a prevalence rate of 5.0%, 3.3% and 1.7%, respectively. Appropriate public health measures must therefore be taken to halt the cycle of infection in the community to forestall possible outbreak in the future.
Diversidad genética en restos humanos de contextos arqueológicos tardíos de la provincia de Santiago del Estero a partir del estudio de ADN mitocondrial

En este artículo se presentan los primeros resultados del secuenciamiento de la Región Hipervariable I del ADN mitocondrial de restos óseos humanos arqueológicos de la provincia de Santiago del Estero, con el objeto de contribuir al conocimiento sobre la diversidad genética de las poblaciones de la llanura santiagueña y los procesos de interacción con grupos de otras regiones de Argentina en tiempos prehispánicos tardíos. Se obtuvieron resultados positivos en 5 de las 10 muestras estudiadas que permitieron la identificación de 5 haplotipos diferentes. Una de las muestras, proveniente del norte del Río Dulce, presenta las mutaciones características del subhaplogrupo D1j, mientras que los demás individuos fueron asignados a linajes derivados de C1. La comparación de los haplotipos obtenidos en este trabajo con secuencias prehispánicas compiladas de la literatura no muestra una conexión con las poblaciones que habitaron el NOA en tiempos tardíos ni tampoco con los grupos chaco-litoraleños. En cambio, se observa claramente un vínculo biológico entre las poblaciones de la llanura santiagueña y los grupos de la región central de Argentina (fundamentalmente de la actual provincia de Córdoba) y de los valles del centro-oeste argentino. A pesar de su reducido número, los haplotipos obtenidos dan cuenta de este fenómeno: de las cinco secuencias obtenidas, tres fueron asignadas a los linajes D1j, C1d1b y C1b+146 que han sido señalados como indicadores de un estrecho vínculo entre las poblaciones del centro y el oeste argentino, y evidenciadel mantenimiento de flujo génico entre ellas.