Miracle-dz/UniFAR-FTUs huggingface dataset:
An Effective Fault Diagnosis Approach Based On Gentle AdaBoost and AdaBoost.MH

With fault causes increasingly specialized in industrial process, data-driven method is becoming an indispensable technique to handle fault diagnosis problems. As efficient and practical data-driven methods, Gentle AdaBoost and AdaBoost.MH are introduced in this paper to diagnose binary faults and multiclass faults, respectively. Moreover, F1 score is developed afterwards as the performance assessment index in order to evaluate the proposed algorithms. Tennessee Eastman Process, a benchmark dataset in chemical engineering, is then adopted as case study for methods comparison in this research. As shown in the experimental results, Gentle AdaBoost achieves promising results on binary fault diagnosis, meanwhile one against one, one against all and AdaBoost.MH are used to extend Gentle AdaBoost to multiclass fault diagnosis case, which also outperforms than supported vector machine, a popular nonlinear binary and multiclass classifier.
Reducing socioeconomic health inequalities: issues of relevance for policy.

During the twentieth century, the health of the Australian population improved markedly: life expectancy increased; the toll of communicable disease was reduced; and, in more recent times, death rates for cardiovascular disease and a number of major cancers have begun to decline. However, against this backdrop of improving overall health, large health inequalities continue to exist between socioeconomic groups; and, for some conditions, these inequalities are increasing over time.
Two-stage screening for early dementia in primary care

ABSTRACT Objective: The objective was to compare two screening strategies for dementia in an urban primary care clinic, serving a low-education, minority community composed largely of Latino and African American patients. Method: Two hundred and fifty-seven patients underwent two-stage patient-based screening (PBS) and informant-based screening (IBS) followed by a diagnostic evaluation. In the first stage, PBS included brief tests of episodic memory (Memory Impairment Screen), semantic memory (Animal Fluency), and executive function (Reciting Months Backwards). For IBS, the first stage consisted of the short Informant Questionnaire on Cognitive Decline in the Elderly, administered to a family member or friend. Patients who screened positive in the first stage of either strategy underwent testing with the picture version of the Free and Cued Selective Reminding Test with Immediate Recall to identify memory impairment. Sensitivity, specificity, and positive and negative predictive values were computed for various cutoffs of each test and combination of tests. Dementia was diagnosed using Diagnostic and Statistical Manual of Mental Disorders–Fourth Edition (DSM–IV) criteria without access to the screening test results. Results: We identified 66 patients (25.7%) with previously undiagnosed dementia. Sensitivity was the same (77%) for both strategies but specificity was higher for IBS than for PBS (92% versus 83%). IBS’s higher specificity makes it the preferred strategy if a knowledgeable informant is available. Conclusion: Unrecognized dementia is common in primary care. Case-finding can be improved using either PBS or IBS two-stage screening strategies.
High Level Architecture For Distributed Agent Simulation In Computer Games

Multi Agent System (MAS) have been in existence for quite a long time and have been a focused area of research in different paradigms over the years. As a result, several test beds and simulation tools exist for their deployment in software engineering problems. However, these test beds are suited for specific agents types and environments and lack support for interoperating with other agent architectures and environments. Further, they do not exploit the power of modern distributed and parallel computing environments. Here at RIATec, there is a powerful escience Beowulf cluster that provides ample resources for distributed simulation of MAS. Such simulation has several possible target applications such as in computer games and training virtual environments and therefore it is important that such simulation is reused. Moreover, good visualization, rendering and interactive tools are needed for evaluating, testing and interacting with the system. In this paper, a proposal for a reusable architecture and visualization test bed based on Highlevel architecture (HLA) and Unreal technology is provided for a high performance MAS simulator.
Capacitor free 100KHz 50mA DMOS voltage regulator

A novel capacitor free DMOS 5V voltage regulator with a maximum output transient load regulation 150mV@100KHz (load current ramp from 500uA to 50mA); 20mV load regulation and 50mV line regulation for 50mA load current is presented. The proposed voltage regulator is based on a novel error amplifier structure and an automatic switching between LDO mode and normal regulator mode in order to minimize the ground current consumption from 1.8mA for 5.5V≪Vin≪8.4V to 750uA for 8.4V ≪Vin ≪28V. The work has been done in Infineon BCD Smart Power Technology for input voltage domain between 5.5V and 28V with absolute maximum input voltage rating 40V.
SHORT COMMUNICATION AQUATIC PREY CAPTURE IN FISHES: EXPERIMENTAL AND THEORETICAL APPROACHES

In our attempts to understand how animals work, the diversity of animal design and the physiological basis of animal behaviour it is common to make theoretical models of animal function and to conduct experiments to test these models. Experimental analyses often provide a direct test of competing models, evaluate the accuracy of assumptions of models and, at a more descriptive level, simply provide increased observational precision. On the other hand, theoretical models may play an important heuristic role in suggesting new experiments and may provide a general predictive framework within which research can progress. The value of a theoretical model of animal function is judged on both the validity of the assumptions that go into the model and on the accuracy of predictions from the model. If it can be shown that a model's assumptions are invalid and that it makes inaccurate predictions, then we must question the utility of the model for furthering our understanding of organismal design. In this journal, Muller, Leeuwen, Osse & Drost (1985) have recently responded to an earlier paper of mine (Lauder, 1983) that outlined three experimental tests of their theoretical model of aquatic prey capture in fishes (Muller, Osse & Verhagen, 1982). These authors suggest that my tests of their model do not invalidate it. In this paper, I will (1) briefly review the key features of this debate, (2) evaluate the experimental tests of the Muller et al. (1982) model and reconsider its validity, and then (3) adduce additional evidence against both the assumptions and predictions provided by Muller et al. (1982). Models of aquatic prey capture Aquatic prey capture in fishes (and many other lower vertebrates) predominantly occurs by suction feeding in which the volume of the mouth is rapidly increased and the intraoral pressure thus decreased (Alexander, 1969; Lauder, 1980a; Liem, 1970). This produces a flow of water that carries the prey into the mouth. At least three reasons underlie the interest in this feeding system over the last 20 years: it is the dominant mode of energy acquisition in vertebrates, the biomechanical basis of the feeding mechanism is extremely complex with over 50 independently mobile
On-line maintenance of the four-connected components of a graph

Given a graph G with n vertices and m edges, a k-connectivity query for vertices v' and v" of G asks whether there exist k disjoint paths between v' and v". The authors consider the problem of performing k-connectivity queries for k<or=4. First, they present a static data structure that answers such queries in O(1) time. Next, they consider the problem of performing queries intermixed with online updates that insert vertices and edges. For triconnected graphs they give a dynamic data structure that supports queries and updates in time O( alpha (l,n)) amortized, where n is the current number of vertices of the graph and l is the total number of operations performed ( alpha (l, n) denotes the slowly growing Ackermann function inverse). For general graphs, a sequence of l operations takes total time O(n log n+l). All of the above data structures use space O(n), proportional to the number of vertices of the graph. The results also yield an efficient algorithm for testing whether graph G is four-connected that runs in O(n alpha (n, n)+m) time using O(n+m) space. <<ETX>>
Little evidence for involvement of MLH3 in colorectal cancer predisposition

Mutations in the DNA MMR genes MSH2, MLH1, MSH6 and PMS2 underlie a large subset of HNPCC cases, and a hallmark of the tumors is MSI. In many HNPCC families, however, a causative mutation has not been found. Therefore, the involvement of additional, thus far unknown, genes in MSI as well as MSS colorectal tumor predisposition is possible. The role of a relatively recently cloned MMR gene, MLH3, in familial CRC has been studied; but the results appear somewhat conflicting. To further evaluate the role of MLH3 in CRC predisposition, we analyzed 30 Finnish CRC cases for germline mutations by sequencing. These cases were selected from a large series of Finnish CRC patients, to match features previously proposed to associate with MLH3 germline defects. We found 5 missense variants, 4 of which were also found in Finnish cancer‐free controls. The only remaining variant does not appear to be an attractive candidate for a disease‐associated mutation because the amino acid change is located outside the conserved residues. We also screened for the previously reported variants, including a frameshift change, the most likely pathogenic MLH3 mutation observed so far. The frameshift was not present in the 30 CRC cases or in 700 cancer‐free controls. While it is a difficult task to exclude a role of MLH3 in HNPCC, our study could not confirm a role for MLH3 in CRC predisposition. © 2003 Wiley‐Liss, Inc.
Neurologic manifestations of Kanzaki disease

We describe the neurologic findings in a patient with α-N-acetylgalactosaminidase deficiency (Kanzaki disease). Clinical and electrophysiologic studies revealed sensory-motor polyneuropathy, and sural nerve pathology showed decreased density of myelinated fibers with axonal degeneration. The patient had mildly impaired intellectual function with abnormal brain MRI and sensory-neuronal hearing impairment with repeated episodes of vertigo attacks. These findings suggest that Kanzaki disease may develop neurologic complications in the CNS and peripheral nervous system.
The combined effect of water status and crop level on Tempranillo wine volatiles.

BACKGROUND The effect of water status and crop level on the volatile composition of Tempranillo wine was investigated over two growing seasons (2010-2011) in Extremadura (Spain). Three water status treatments (T0, Rainfed control; T1, Early regulated deficit irrigation; T2, Late regulated deficit irrigation) were combined with two crop levels treatments (TH, cluster thinning; C, control). RESULTS Crop level treatment had a higher effect on individual volatiles analyzed in Tempranillo wine than water status. The combinations of water status and crop level treatments showed effects on all families of compounds with the exception of acetates and volatile fatty acids. Alcohols, C6 compounds and phenol volatiles produced the highest concentrations at the lower level of available water and when cluster thinning was applied (T0-TH). However, ethyl ester and lactones showed higher concentrations in regulated deficit irrigation (T1 and T2) and when cluster thinning was not applied. CONCLUSION The combined effect of rainfed and cluster-thinning treatments (T0-TH) increased the majority of individual aromatic compounds quantified in Tempranillo wines and also showed the highest total odor activity value. © 2016 Society of Chemical Industry.
Technology for Millimetre Wave Radiometers

Technology for millimetre wave radiometers is discussed. Distinction between coherent and incoherent detection is also addressed. As an example, details of the 70 GHz ultra low noise and high stability receivers for the European Space Agency (ESA) Planck Mission is given. These receivers are part of the Low Frequency Instrument (LFI). The LFI receivers will make use of Monolithic Microwave Integrated Circuits (MMIC) and the key components are the Low-Noise Amplifiers (LNA). Indium Phosphide (InP) technology has been used for manufacturing the HEMT and PIN diode MMICs. Recently complete Elegant Breadboard Model (EBB) of LFI 70 GHz receivers have demonstrated a 30 K noise temperature with 16 GHz bandwidth and a 1/f knee frequency of 30 mHz. Described radiometer modules form flexible basis for constructing radiometers with many pixels for millimetre wave imaging and remote sensing applications.
Antibody-Independent Antiviral Function of Memory CD4+ T Cells In Vivo Requires Regulatory Signals from CD8+ Effector T Cells1

Previous studies have shown that vaccine-primed CD4+ T cells can mediate accelerated clearance of respiratory virus infection. However, the relative contributions of Ab and CD8+ T cells, and the mechanism of viral clearance, are poorly understood. Here we show that control of a Sendai virus infection by primed CD4+ T cells is mediated through the production of IFN-γ and does not depend on Ab. This effect is critically dependent on CD8+ cells for the expansion of CD4+ T cells in the lymph nodes and the recruitment of memory CD4+ T cells to the lungs. Passive transfer of a CD8+ T cell supernatant into CD8+ T cell-depleted, hemagglutinin-neuraminidase (HN)421–436-immune μMT mice substantially restored the virus-specific memory CD4+ response and enhanced viral control in the lung. Together, the data demonstrate for the first time that in vivo primed CD4+ T cells have the capacity to control a respiratory virus infection in the lung by an Ab-independent mechanism, provided that CD8+ T cell “help” in the form of soluble factor(s) is available during the virus infection. These studies highlight the importance of synergistic interactions between CD4+ and CD8+ T cell subsets in the generation of optimal antiviral immunity.
Machine Vision Based Classification Of Tobacco Leaves For Automatic Harvesting

Abstract A machine vision based approach for classification of tobacco leaves for automatic harvesting in a complex agricultural environment is proposed in this paper. The CIELAB color space model is used to segment the leaf from the background. The segmented leaves are classified into three classes viz., ripe, unripe, and over-ripe. Models based on various textural features such as GLTP (Gray Level Local Texture Patterns), LBP (Local Binary Pattern) and LBPV (Local Binary Pattern Variance) are studied in this work. The K-Nearest Neighbor (K-NN) classifier based on the Euclidean distance measure has been used for classification. Experiment is conducted on our own dataset consisting of 244 images of tobacco leaves captured in both sunny and cloudy lighting conditions in a real tobacco field. The experimental results show that GLTP model achieves significant improvement in classification accuracy over traditional LBP and LBPV.
Hop: more than an Hsp70/Hsp90 adaptor protein

Molecular chaperones facilitate the correct folding of other proteins under physiological and stress conditions. Recently it has become evident that various co‐chaperone proteins regulate the cellular functions of these chaperones, particularly Hsp70 and Hsp90. Hop is one of the most extensively studied co‐chaperones that is able to directly associate with both Hsp70 and Hsp90. The current dogma proposes that Hop functions primarily as an adaptor that directs Hsp90 to Hsp70‐client protein complexes in the cytoplasm. However, recent evidence suggests that Hop can also modulate the chaperone activities of these Hsps, and that it is not dedicated to Hsp70 and Hsp90. While the co‐chaperone function of Hop within the cytoplasm has been extensively studied, its association with nuclear complexes and prion proteins remains to be elucidated. This article will review the structural features of Hop, and the evidence that its biological function is considerably broader than previously envisaged. BioEssays 26:1058–1068, 2004. © 2004 Wiley Periodicals, Inc.
Tunicamycin treatment of CHO cells abrogates multiple blocks to retrovirus infection, one of which is due to a secreted inhibitor

Chinese hamster ovary (CHO) cells are resistant to infection by all of the major classes of murine retroviruses and are partially resistant to infection by gibbon ape leukemia virus. Treatment of CHO cells with the glycosylation inhibitor tunicamycin rendered these cells susceptible to infection by retroviral vectors with ecotropic, xenotropic, and amphotropic host ranges and increased the titer of gibbon ape leukemia virus pseudotyped vectors 10-fold. Vectors having a polytropic host range did not infect CHO cells in the presence or absence of tunicamycin, showing that the effect of tunicamycin was specific and related to the pseudotype of the vector. We present evidence for three mechanisms of resistance to infection: lack of viral receptors on CHO cells, the presence of nonfunctional receptors which can be made functional by treatment with tunicamycin, and the secretion of a protein factor that blocks retroviral infection of CHO cells. Several criteria indicate that the secreted inhibitor is not an interferon, and secretion of this factor was not detected in several other cell lines that were examined.
Clinical Experience with Goal Attainment Scaling in Geriatric Care

Objectives: This article presents a qualitative evaluation of the utility of Goal Attainment Scaling (GAS) in geriatric care. GASis an individualized outcome measure particularly suited for clients with multiple complex problems, such as are commonly served by geriatric programs. Methods: Semistructured interviews were completed with 24 clinicians in four hospital or community-based geriatric services where GAS has been used. An inductive analysis was used to identify themes. Results: GAS was described as resulting in shorter lengths of stay, more focused care, and improved team functioning. GAS was perceived as having greater use for functional (versus medical) goals, when clinicians had more direct control over treatments, when patients were involved in goal-setting, and when goals were set by an interdisciplinary team. Discussion: GAS has affected both care practices and patient outcomes. This study illustrates the clinical impacts an outcome measure can have, as well as the use of qualitative methods for this type of research.
NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS

A number of small organic ribonucleases have been synthesized with rigid polycationic structures containing an aromatic framework with two residues of bisquaternary salts of 1,4-diazabicyclo[2.2. 2]octane (DABCO) bearing various substituents. The compounds carrying positively charged groups connected via rigid linker are expected to bend the sugar-phosphate backbone and can stimulate the intramolecular phosphoester transfer reaction.
Progression of renal disease in Henoch-Schönlein purpura after influenza vaccination.

To the Editor. — The article by Herron et al (242:53, 1979) reports convincingly the safety and efficacy of influenza vaccination in patients with various immunologically mediated diseases. Since there are no major complications of recent influenza vaccination on record, we want to report our experience with a patient with Henoch-Schonlein purpura, whose mild renal disease progressed irreversibly after influenza vaccination. Report of a Case. — A 23-year-old man with a ten-year history of Henoch-Schonlein purpura was hospitalized in November 1976, three weeks after vaccination with the whole bivalent influenza virus vaccine (A/NJ and A/Vict). The symptoms included fever, abdominal colics, gross hematuria, joint pains, and skin purpura. The blood pressure reading was 160/100 mm Hg. Stools were positive for blood, and the urine contained blood and RBC casts. The serum protein level was 4 g/24 hr. The level of serum BUN was 43 mg/dL; creatinine, 3.3 mg/dL; and creatinine clearance, 36
Asynchronous burst-mode control for low-power gated-clock finite state machines

Design of contemporary digital circuits has great need of power reduction. The reasons are owing to portable applications and CMOS Deep-Sub-Micron technology. Finite state machines (FSM) play an important role in these circuits. The partitioning of an FSM into several sub-FSMs is a technique widely used in the reduction of energy consumption. An interesting style for activating and deactivating sub-FSMs is the asynchronous communication proposed by Oelmann. In this paper we propose a high performance control to the asynchronous communication between sub-FSMs. Compared with Oelmann's control, our control consumes less power, occupies less area and has a smaller cycle time.
Immunohistochemical detection of myogenin and p21 in methylcholanthrene‐induced mouse rhabdomyosarcomas

3‐Methylcholanthrene (MC)‐induced 10 embryonal (ERSs) and 24 pleomorphic rhabdomyosarcomas (PRSs) of the dermis in mouse were examined immunohistochemically for myogenin, p21 and proliferating cell nuclear antigen (PCNA) nuclear reactivity and myosin reactivity. ERSs had higher expression of myogenin and p21 compared with that of myosin. PRSs were divided into two groups having high (moderate or marked reactivity; HLM) and low (mild reactivity; LLM) levels of myosin expression. Expression of p21 was higher in HLM‐PRSs than in LLM‐PRSs. Statistically significant association was observed between myosin and p21 expression in PRSs, but not between myosin and myogenin expression. Myogenin and p21 reactivity were observed in myoblast‐like cells, but rarely in multinucleated cells. In ERSs, small undifferentiated myogenic precursor cells were also positive for p21. No difference of PCNA reactivity was observed between HLM‐PRSs and LLM‐PRSs, although its reactivity was higher in PRSs than in ERSs. The results suggest that myogenin is related to myoblast‐like cell differentiation in PRSs and that p21 plays essential roles in myotube formation and myosin expression. In ERSs, p21 may be involved in inhibition of myogenic precursor cell proliferation and differentiation.
Use of live and oil emulsion Newcastle disease vaccines on day-old broilers: report on two trials

Two trials were carried out using broilers to test the effectiveness of concurrent live and oil emulsion Newcastle disease vaccines at day-old. The first trial compared this system, using a Newcastle disease oil emulsion vaccine formulated for adult birds, with the conventional programme of live vaccine only. The second trial used an oil emulsion vaccine specially formulated for a day-old dose fo 0.1 ml. It also examined the effect of an additional dose of live vaccine at 14 days old. The results show that birds were as well protected and grew at least as well when vaccinated at one day old and that the special low-dose oil emulsion gave as good protection against Newcastle disease as the higher dose vaccine. The additional live vaccine treatment in the second trial did not appear to increase the beneficial effects.