Miracle-dz/UniFAR-FTUs huggingface dataset:
Outpatient Total Shoulder Arthroplasty

Background: Orthopaedic surgical procedures are increasingly being performed in outpatient settings. The drive for cost reduction without compromising patient safety and outcomes has increased interest in outpatient total shoulder arthroplasty (TSA). The primary aim of this study was to perform a review of the evidence regarding the outcomes and cost-effectiveness of outpatient TSA. Methods: A search of the PubMed, Embase, and Cochrane Library databases was performed using several keywords: “outpatient,” “shoulder replacement,” “ambulatory,” “day case,” “day-case,” “shoulder arthroplasty,” “same day,” and “shoulder surgery. ” Studies that were published from May 2010 to May 2020 in the English language were considered. Research design, questions, and outcomes were recorded for each study. Qualitative and quantitative pooled analysis was performed on the data where appropriate. Results: Twenty studies met the inclusion criteria. Six retrospective studies compared complication rates between inpatient and outpatient cohorts and found no significant differences. Four studies found that the complication rate was lower in the outpatient cohort compared with the inpatient cohort. In a pooled analysis, the readmission rate after outpatient TSA was significantly lower than the readmission rate after inpatient TSA at 30 days (0.65% vs. 0.95%) and 90 days (2.03% vs. 2.87%) postoperatively (p < 0.05 for both). Four studies evaluated the cost of outpatient TSA in comparison with inpatient TSA. All of these studies found that TSA at an ambulatory surgery center was significantly less costly than TSA at an inpatient facility, both for the health-care system and for the patient. Patient selection for outpatient TSA may depend on several important factors, including the presence or absence of diabetes, chronic obstructive pulmonary disease, chronic kidney disease, congestive heart failure, poor functional status, higher American Society of Anesthesiologists class, chronic narcotic use, higher body mass index, and older age. Conclusions: Our results show that patient selection is the most critical factor that predicts the success of outpatient TSA. While outpatient TSA is significantly less costly than inpatient TSA, patients undergoing outpatient TSA are more likely to be healthier than patients undergoing inpatient TSA. More high-quality long-term studies are needed to add to this body of evidence. Level of Evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Utilization of GelMA with phosphate glass fibers for glial cell alignment.

Glial cell alignment in tissue engineered constructs is essential for achieving functional outcomes in neural recovery. While gelatin methacrylate (GelMA) hydrogel offers superior biocompatibility along with permissive structure and tailorable mechanical properties, phosphate glass fibers (PGFs) can provide physical cues for directionality of neural growth. Aligned PGFs were fabricated by a melt quenching and fiber drawing method and utilized with synthesized GelMA hydrogel. The mechanical properties of GelMA and biocompatibility of the GelMA-PGFs composite were investigated in vitro using rat glial cells. GelMA with 86% methacrylation degree were photo-crosslinked using 0.1%wt photo-initiator (PI). Photocrosslinking under UV exposure for 60 s was used to produce hydrogels (GelMA-60). PGFs were introduced into the GelMA before crosslinking. Storage modulus and loss modulus of GelMA-60 was 24.73 ± 2.52 and 1.08 ± 0.23 kN/m2 , respectively. Increased cell alignment was observed in GelMA-PGFs compared with GelMA hydrogel alone. These findings suggest GelMA-PGFs can provide glial cells with physical cues necessary to achieve cell alignment. This approach could further be used to achieve glial cell alignment in bioengineered constructs designed to bridge damaged nerve tissue.
On Fixed Marginal Distributions and Psychometric Network Models

Abstract This reply addresses the commentary by Epskamp et al. (in press) on our prior work, of using fixed marginals for sampling the data for testing hypothesis in psychometric network application. Mathematical results are presented for expected column (e.g., item prevalence) and row (e.g., subject severity) probabilities under three classical sampling schemes in categorical data analysis: (i) fixing the density, (ii) fixing either the row or column marginal, or (iii) fixing both the row and column marginal. It is argued that, while a unidimensional structure may not be the model we want, it is the structure we are confronted with given the binary nature of the data. Interpreting network models in the context of this artifactual structure is necessary, with preferred solutions to be expanding the item sets of disorders and moving away from the use of binary data and their associated constraints.
Antioxidant Activity of Waterleaf (Talinum triangulare (Jacq.) Willd) Cultivated with Organic Fertilizers during the Rainy Season

STELLA ALINNESHIA. Antioxidant Activity of Waterleaf (Talinum triangulare (Jacq.) Willd) Cultivated with Organic Fertilizers during the Rainy Season. Supervised by PROF. DR. IR. RIZAL SYARIEF, DESS and DR. IR. DIDAH NUR FARIDAH, M.Si. Talinum triangulare (Jacq.) Willd, known as ginseng Jawa or kolesom Jawa in Indonesia, is one of tropical plants that has been widely used as traditional herbal medicine and consumed as vegetable in Indonesia. The leaf from the plant contains bioactive compound identified as flavonoid which can function as antioxidant. The objective of this research was to measure the antioxidant activity and total phenolic compound of waterleaf in five different treatments of organic fertilization. Extraction of the leaf was carried out with the method of ultrasound assisted extraction/UAE (sample:MeOH=1:10 b/v, t=20 minutes, cold extraction room temperature). The present research resulted that the different organic fertilizer treatments significantly influenced the secondary metabolites content e.g. phenolic content of Talinum triangulare (Jacq.) Willd (p<0.05). High total phenolic content did not always exhibit high antioxidant activity as the highest total phenolic content group (PK+RP: 10.76 mg GAE/g dry sample) had weaker antioxidant activity (DPPH: 1.73 ± 0.01 mg AEAC/g GAE) than thus lower in phenolic content. Organic fertilizer RP+AS (rock phosphate and husk ash) treatment (7.36 ± 0.00 g GAE/g dry sample) exhibited the highest antioxidant activity in scavenging DPPH free radicals and strongest reducing power among all groups (2.06 ± 0.01 mg AEAC/g GAE; 0.022 ± 0.000 mg AEAC/g GAE respectively). Organic fertilizer influenced the secondary metabolite produced by the waterleaf.
A pragmatic randomised controlled clinical study to evaluate the use of silicone dressings for the treatment of skin tears

One of the most common types of skin breakdown in ageing populations is skin tears. The International Skin Tear Advisory Panel advocates for special attention to be paid to dressing selection related to skin tear management. The panel recommends choosing dressings that will promote the maintenance of moisture balance, suit the local wound environment, protect peri‐wound skin, control or manage exudate and infection, and optimise caregiver time. It is paramount that dressings protect the fragile nature of the skin associated with those who at heightened risk for skin tear development. To compare the effectiveness of soft silicone dressings (a contact layer and/or foam) for the healing of skin tears with local practices that do not include soft silicone dressings. The study was a pragmatic randomised controlled prospective study. One hundred and twenty‐six individuals from two long‐term care facilities in Ontario Canada who presented with skin tears were randomised into the treatment group using either soft silicone dressings (a contact layer and/or foam) or the control group using non‐adhesive dressings. The current study demonstrated that 96.9% (n = 63) of skin tears in the treatment group healed over a 3‐week period compared with 34.4% (n = 21) in the control group. The proportion of wound healing experienced at week 2 was 89.2% (n = 58) in the treatment group compared with 27.9% (n = 17) in the control group. There was a significantly greater reduction in wound surface area relative to baseline in the treatment group (2.9 cm2) compared with the control group (0.6 cm2) (χ2 = 21.792 P < .0001) at week 1. Survival analysis data supported that skin tears healed 50% faster in the treatment group (11 days) compared with the control group (22 days) (χ2 = 59.677 P < .0001). The expected healing trajectory of acute wounds, including skin tears, if proper wound bed preparation is realised and infection is controlled, is 7 to 21 days. Results of this study suggest the use of silicone dressings support wound healing and aid in wound closure within the expected healing trajectory, with faster complete wound closure and mean healing times compared with non‐silicone dressing for the treatment of STs.
Evidence for the preferential reuse of sub‐domain motifs in primordial protein folds

A comparison of protein backbones makes clear that not more than approximately 1400 different folds exist, each specifying the three‐dimensional topology of a protein domain. Large proteins are composed of specific domain combinations and many domains can accommodate different functions. These findings confirm that the reuse of domains is key for the evolution of multi‐domain proteins. If reuse was also the driving force for domain evolution, ancestral fragments of sub‐domain size exist that are shared between domains possessing significantly different topologies. For the fully automated detection of putatively ancestral motifs, we developed the algorithm Fragstatt that compares proteins pairwise to identify fragments, that is, instantiations of the same motif. To reach maximal sensitivity, Fragstatt compares sequences by means of cascaded alignments of profile Hidden Markov Models. If the fragment sequences are sufficiently similar, the program determines and scores the structural concordance of the fragments. By analyzing a comprehensive set of proteins from the CATH database, Fragstatt identified 12 532 partially overlapping and structurally similar motifs that clustered to 134 unique motifs. The dissemination of these motifs is limited: We found only two domain topologies that contain two different motifs and generally, these motifs occur in not more than 18% of the CATH topologies. Interestingly, motifs are enriched in topologies that are considered ancestral. Thus, our findings suggest that the reuse of sub‐domain sized fragments was relevant in early phases of protein evolution and became less important later on.
Machine learning techniques applied to the drug design and discovery of new antivirals: a brief look over the past decade

ABSTRACT Introduction: Drug design and discovery of new antivirals will always be extremely important in medicinal chemistry, taking into account known and new viral diseases that are yet to come. Although machine learning (ML) have shown to improve predictions on the biological potential of chemicals and accelerate the discovery of drugs over the past decade, new methods and their combinations have improved their performance and established promising perspectives regarding ML in the search for new antivirals. Areas covered: The authors consider some interesting areas that deal with different ML techniques applied to antivirals. Recent innovative studies on ML and antivirals were selected and analyzed in detail. Also, the authors provide a brief look at the past to the present to detect advances and bottlenecks in the area. Expert opinion: From classical ML techniques, it was possible to boost the searches for antivirals. However, from the emergence of new algorithms and the improvement in old approaches, promising results will be achieved every day, as we have observed in the case of SARS-CoV-2. Recent experience has shown that it is possible to use ML to discover new antiviral candidates from virtual screening and drug repurposing.
Simulation of charge transport in amorphous organic semiconductors

Viele Anwendungen der organischen Elektronik wie beispielsweise organische Leuchtdioden (OLEDs) oder organische Photovoltaik (OPV) basieren auf amorphen halbleitenden Molekulen. Die fast unendlichen Variationsmoglichkeiten organischer Materialien erschweren gezielte experimentelle Materialentwicklung. Bestehende Theorien fur den Ladungstransport in amorphen Materialien basieren weitgehend auf empirischen Materialparametern und konnen so nicht zur pradiktiven Vorhersage von Eigenschaften neuer Materialien benutzt werden. In dieser Arbeit werden Modelle entwickelt, die dem Zweck dienen, den Zusammenhang zwischen mikroskopischen Molekuleigenschaften und deren makroskopischer Leitfahigkeit zu verstehen und somit die Ladungstragermobilitat neuer Materialien vorauszusagen. Zwei Aspekte stellen bei der Entwicklung von Modellen fur den Ladungstransport in amorphen Materialien besondere Herausforderungen dar. Zum einen mussen Effekte auf vielen Grosenskalen berucksichtigt werden, die von der elektronischen Struktur einzelner Molekule in Subnanometerbereich bis hin zu Perkolationseffekten im Mikrometermasstab reichen. Zum anderen hangt die Ladungstragermobilitat exponentiell von der Energieunordnung im amorphen Material ab. Diese wird von der Konformation einzelner Molekule sowie von deren Wechselwirkung mit ihrer ungeordneten Umgebung bestimmt. Um die Effekte auf allen Grosenskalen zu berucksichtigen, wird in dieser Arbeit ein Multiskalenmodell zur Simulation von Ladungstransport in organischen Halbleitern vorgestellt. Die Energieunordnung atomar aufgeloster Morphologien wird mithilfe der Quantum Patch Methode bestimmt, die die elektronische Struktur amorpher Molekule selbstkonsistent bestimmt. Die mit diesem Modell berechnete Ladungstragermobilitat zeigt gute Ubereinstimmung mit experimentellen Daten. Daruber hinaus erlaubt das Modell eine Zerlegung der Ladungstragermobilitat in Faktoren, die von einzelnen Molekuleigenschaften abhangen. Dies ermoglicht die Ableitung von Designkriterien fur neue organische Molekule. Mithilfe dieser Kriterien wurde die Elektronenmobilitat eines bekannten Materials durch Anderung der chemischen Struktur gezielt erhoht. Bei dieser Modifikation wurden die Energielevels bewusst konstant gehalten, um optische Eigenschaften nicht zu verandern. Das somit gewonnene Material wurde synthetisiert und elektronisch charakterisiert. In Ubereinstimmung mit den theoretischen Vorhersagen zeigt das Material eine um drei Grosenordnungen erhohte Elektronenmobilitat. Dieses Beispiel demonstriert die Durchfuhrbarkeit von in-silico Materialentwicklung.
Finding the Sweet Spot: Measurement, Modification, and Application of Sweet Hedonics in Humans

ABSTRACT Sweetness is a sensation that contributes to the palatability of foods, which is the primary driver of food choice. Thus, understanding how to measure the appeal (hedonics) of sweetness and how to modify it are key to effecting dietary change for health. Sweet hedonics is multidimensional so can only be captured by multiple approaches including assessment of elements such as liking, preference, and consumption intent. There are both innate and learned components to the appeal of sweet foods and beverages. These are responsive to various behavioral and biological factors, suggesting the opportunity to modify intake. Given the high amount of added sugar intake in the United States and recommendations from many groups to reduce this, further exploration of current hypothesized approaches to moderate sugar intake (e.g., induced hedonic shift, use of low-calorie sweeteners) is warranted.
Determinants of trophic cascade strength in freshwater ecosystems: a global analysis.

Top-down cascade effects are among the most important mechanisms underlying community structure and abundance dynamics in aquatic and terrestrial ecosystems worldwide. A current challenge is understanding the factors controlling trophic cascade strength under global environmental changes. Here, we synthesized 161 global sites to analyze how multiple factors influence consumer-resource interactions with fish in freshwater ecosystems. Fish have a profound negative effect on zooplankton and water clarity but positive effects on primary producers and water nutrients. Furthermore, fish trophic levels can modify the strength of trophic cascades, but an even number of food chain length does not have a negative effect on primary producers in real ecosystems. Eutrophication, warming and predator abundance strengthen the trophic cascade effects on phytoplankton, suggesting that top-down control will be increasingly important under future global environmental changes. We found no influence or even an increasing trophic cascade strength (e.g., phytoplankton) with increasing latitude, which does not support the widespread view that the trophic cascade strength increases closer to the equator. With increasing temporal and spatial scales, the experimental duration has an accumulative effect, while the experimental size is not associated with the trophic cascade strength. Taken together, eutrophication, warming, temporal scale and predator trophic level and abundance are pivotal to understanding the impacts of multiple environmental factors on the trophic cascade strength. Future studies should stress the possible synergistic effect of multiple factors on the food web structure and dynamics.
The Bern Early Recognition and Intervention Centre for mental crisis (FETZ Bern)—An 8‐year evaluation

Early detection of, and intervention for, psychosis during its prodromal phase has the potential to alter the course of the disease and has therefore become a major objective of modern clinical psychiatry. An increasing number of early detection and intervention services have been established in Europe and worldwide. This study aims to describe and evaluate an early detection and intervention service for children, adolescents and adults (FETZ Bern) aged from eight to 40 years with a population catchment area of 1.035 million in Bern, Switzerland.
Neural Mechanisms of Hypnosis and Meditation-Induced Analgesia: A Narrative Review

ABSTRACT Meditation and hypnosis have both been found to attenuate pain; however, little is known about similarities and differences in the cognitive modulation of pain. Hypnotic and meditative states (e.g., mindfulness) reduce pain by sharing and overlapping multiple neuro-cognitive mechanisms, but they differ in many respects. While there are overlapping brain networks involved, the nature of these effects seems different. Both phenomena involve frontal modulation of pain-related areas. The role of the dorsolateral prefrontal cortex appears to depend, in hypnosis, on the type of suggestion given and, in meditation, on the level of practice. Whereas the anterior cingulate cortex seems to be a key node in both hypnosis and meditation, the dorsolateral prefrontal cortex appears to engage in hypnosis as a function of suggestion and, in meditation, as a function of proficiency.
Presence of biogenic amines in food and their public health concerns.

Essential foods of a daily meal have been reported to comprise of numerous kinds of biogenic amines (BAs) at different levels. BAs have a variety of toxicological impacts on human health, and they have been connected to multiple outbreaks of foodborne disease. They also are known to cause cancer based on their ability to react with nitrite salts resulting in the production of a carcinogenic organic compound (i.e. nitrosamines). BAs toxicity is often linked to the ingestion of large quantities of BAs in food that causes toxicological threats and health disorders and has psychoactive, vasoactive, and hypertensive effects and can cause respiratory, gastrointestinal, cardiovascular and neurological disorders. Toxicity properties of BAs are linked closely to histamine and tyramine. Other amines, such as phenylethylamine, putrescine, and cadaverine are meaningful because they could increase histamine's negative effects. The key method for reducing BA concentration and foodborne disease is bacterial load management. It helps to control the formation of histamine and other BAs, and also reduce histamine and tyramine toxicity by applying basic good handling and hygiene practices. A greater understanding of BAs is essential to enhance food safety and quality. This review paper discusses the public health concerns of BAs in foods.
D-003: Antiplatelet therapy treatment of lipoprotein disorders

D-003 is a mixture of very-high-molecular weight aliphalic acids purified from sugar cane (Saccharum offic inarum L.) wax with cholesterol- lowering and pleiotropic effects and this complications. D-003 inhibits cholesterol biosynthesis through the regulation of HMG-CoA reductase activity. Following oral administration to rabbits and dogs, it dose-dependently reduced serum levels of total (TC) and low-density lipoprotein cholesterol (LDL-C), whereas it increased high-density lipoprotein cholesterol (HDL-C) and had no effect on triglycerides (TG); these effects persisted after long-term treatment. Further experiments in hypercholesterolemic rabbits showed that D-003 prevented the increase in serum LDL and inhibited the de novo synthesis of cholesterol, increasing the binding of LDL to liver homogenates and the removal of serum LDL. D-003 consistently prevented experimental arterial thrombosis and ischemia, and inhibited the development of foam cells and cuff-induced carotid neointimal proliferation in rabbits. Orally administered D-003 also exerted extravascular effects, the most relevant being prevention of bone loss induced by ovariectomy in rats. Results from experimental toxicology studied have not shown any D-003-related toxicity. In healthy subjects, D-003 (5-50 mg/day) over the short term lowered serum LDL-C and TC, increases HDL-C and had no effect on TG. Bleeding time was increased on the highest dose, but individual values were normal. D-003 (10 and 20 mg/day) for 10-14 days significantly inhibited platelet aggregation induced by arachidonic acid and collagen, but not ADP, had no effect on coagulation time, lowered serum TxB 2 and increased PGI. 2 levels.
Psychosocial Correlates of Excessive Social Media Use in a Hispanic College Sample

Excessive social media has emerged as a potential behavioral addiction with multiple consequences, especially in young adulthood (18-24 years). This study aimed to assess the relationship between excessive social media use, sociodemographics, and psychosocial constructs in a Hispanic college student sample. College students (n = 621; n = 456 females; n = 160 males) from a university located on the U.S./Mexico border completed a survey assessing sociodemographics, social media addiction, social media use, and psychosocial constructs (e.g., Internet motives, sensation seeking, and need for drama [NFD]). Descriptive analyses were conducted, as were two linear regressions assessing weekly social media use and social media addiction. Participants reported using social media an average of 20 hours a week (SD = 19.47). In addition, 57.9 percent of participants reported using social media once a day or more, whereas 15.1 percent met the social media addiction threshold. Weekly social media use was positively associated with NFD, socialization, and coping as motives while being negatively associated with age. Social media addiction was positively associated with NFD and coping while being negatively associated with age. Findings suggest that Hispanic college students evidence high social media use rates and may be using social media as an unhealthy strategy to deal with negative mood and daily problems. Furthermore, college students may be using social media as an avenue to engage in attention-seeking behaviors and manipulation of others. Prospective studies are warranted to assess these relationships temporally, as are intervention efforts aimed at reducing excessive social media use.