Miracle-dz/UniFAR-FTUs huggingface dataset:
LACOSAMIDA COMO TERAPIA ADJUVANTE EM PACIENTES COM EPILEPSIA DE DIFÍCIL CONTROLE

Epilepsy is the most common chronic neurological disease in the world, with prevalence of 1 to 2% and may have physical, social and emotional consequences. Lacosamide has been acting as an adjuvant therapy in the control of seizures, improving the patients' quality of life. Objective: To evaluate the effectiveness of Lacosamide (100mg, 200mg and 400mg) in the adjuvant treatment of patients with difficulty to control epilepsy. Methodology: This is an interventional and longitudinal study. Held at the Foundation of Neurology and Neurosurgery-Brain Institute (FNNIC), started in July 2016. The sample population is random, non-probabilistic and for convenience. We selected 13 patients with convulsive seizures of difficult control from an outpatient clinic specialized in epilepsy. Lacosamide was associated with other prior-use medications which were not modified during the study. The dose of the drug was increased according to clinical response and tolerance. Results: Thirteen patients were selected, of whom had the following side effects: 8 presented dizziness, 6 nausea, 5 vertigo, 2 diplopia and 1 headache. 4 had no side effects. The therapeutic regimen ranged from 100mg / day to 400mg / day. We observed that the median of the seizures presented a decrease when we compared the basal period with the titration and maintenance period. Regarding the dose used, we observed that during the titration period, patients who used 100mg / day presented a median number of attacks less than patients who used a dose greater than 100mg / day (P = 0.01). Conclusion: Epilepsy is a disease that affects patients' quality of life, mainly due to the emotional and social damages that it causes. Therefore, effective control of seizures is important in order to minimize damage to the patient. We believe that Lacosamide is useful for the adjunctive treatment in patients with difficult-to-control seizures.
Epidermal Growth Factor Receptor Expression Analysis In Different Racial Glioma Patients

Epidermal Growth Factor Receptor Expression Analysis in Different Racial Glioma Patients. Abstract Background Vascular Endothelial Growth Factor (VEGF) represents a prom-ising anti-neoplastic target. VEGF expression in same pathological grade of glioma in different ethnicities patients has not been inte-grated into clinical practice yet. The aim of our study is to investigate the relationship between VEGF expression level and prognosis in different ethnicities patients with glioma of
UV-B Radiations and Secondary Metabolites

Ultraviolet-B (UV-B: 280 to 320 nm) radiations have appeared to be detrimental to plants, due to their damaging effects on proteins, lipids, membranes and DNA. UV-B radiations are a significant regulator of plants’ secondary metabolites. High intensity of ultraviolet radiations may interfere with growth and productivity of crops. But low levels of UV-B radiations give rise to changes in the plants’ secondary metabolites such as phenolic compounds, carotenoids and glucoseinolates. Therefore, low intensity of UV-B radiations may be used to generate plants, enriched with secondary metabolites, having improved reproductive ability, early ripening and tolerance against fungi, bacteria and herbivores.
A36 THE GLOBAL INCIDENCE OF PEPTIC ULCER DISEASE AND ITS COMPLICATIONS AT THE TURN OF THE 21ST CENTURY: A SYSTEMATIC REVIEW.

Background The incidence of peptic ulcer disease (PUD) and its complications varies across the world and has changed over the past few decades with the discovery of H. pylori as a major etiological factor in the disease pathogenesis, as well as the increasing use of NSAIDs. We conducted a systematic review to determine differences in the worldwide incidence of PUD and its complications in different regions at the turn of the 21st century.
Discriminative Spectral Pattern Analysis for Positive Margin Detection of Prostate Cancer Specimens using Light Reflectance Spectroscopy

ABSTRACT For localized prostate cancer, one treatment is prostatectomy which surgically removes the prostate gland. However, some undetectable cancer cells may be left as positive surgical margins, leading to a high risk of cancer recurrence. It is highly desirable to develop a portable and accurate classification methodology that detects positive margins on human prostate specimens immediately after their removal during surgery. This study applied data mining techniques on the light reflectance spectroscopy (LRS) data taken from ex-vivo human specimens and developed a novel classification algorithm that could enable real-time, positive-margin identification during surgery. Specifically, the LRS measurements taken from human prostate specimens ex vivo were classified to normal or cancerous tissue with support vector machines and were also classified to normal, cancerous and transition-to-cancer class with an ensemble of trees. The data in this study were highly overlapped and imbalanced among classes. We solved the overlapping issue by defining a middle class (transition-to-cancer), and by optimizing a moving spectral window through the range of LRS. To solve the imbalanced problem, we removed irregular tissue measurements, followed by application of random undersampling from the majority class. We achieved sensitivity and specificity of 100% and 82% for binary classification.
Kritički građani ili nezadovoljni autokrati?

Mijenjaju li se stavovi građana o demokraciji u uvjetima povećane institucionalne nestabilnosti i promjena u stranačkom sustavu u Hrvatskoj u posljednjih nekoliko godina? Nastojeći odgovoriti na to pitanje, autori polaze od koncepta političke potpore demokraciji kakav je izvorno zamislio David Easton, a nadogradili su ga i operacionalizirali Russel Dalton i Pippa Norris. U članku se analiziraju odnos difuzne i specifične potpore demokraciji u Hrvatskoj od 1999. do 2018. i utjecaj na ponašanje birača u oblicima glasovanja za etablirane stranke (lojalnost), nove i marginalne stranke (glas) te apstinencije (izlazak). Analiza obuhvaća sedam vremenskih točaka anketnih istraživanja izbora od 1999. do 2018. i nadovezuje se na druga istraživanja potpore demokraciji u Hrvatskoj. Rezultati potvrđuju da se s vremenom produbio jaz između normativne potpore i zadovoljstva funkcioniranjem demokracije, što se ogleda u povećanju broja kritičkih demokrata i nezadovoljnih autokrata. Premda su obje skupine još razmjerno ravnomjerno raspoređene među etabliranima i novim strankama, ima naznaka da nezadovoljni autokrati sve češće biraju "glas" umjesto "izlaska". Pritom, ukupna slika unutarnje strukture potpore demokraciji nakon 2015. sve više nalikuje na stanje prije velikih institucionalnih promjena 2000, što pridaje posebnu dimenziju političkim promjenama 2015. i 2016. i otvara pitanje o utjecaju uspjeha novih političkih aktera na potporu demokraciji u Hrvatskoj.
How to make theEuropean Green Deal work. Bruegel Policy ContributionIssue n˚14 | November 2019

European Commission president-designate Ursula von der Leyen has made climate change a top priority, promising to propose a European Green Deal that would make Europe climate neutral by 2050. The European Green Deal should be conceived as a reallocation mechanism, fostering investment shifts and labour substitution in key economic sectors, while supporting the most vulnerable segments of society throughout the decarbonisation process. The deal’s four pillars would be carbon pricing, sustainable investment, industrial policy and a just transition.
Robust Optimization Model for Energy Purchase and Sale of Electric–Gas Interconnection System in Multi-Energy Market

With the increasing coupling of the power system and the natural gas system, the electric–gas interconnection system has become a typical form of comprehensive energy utilization. Through the energy conversion function of the coupling unit, the system can flexibly participate in the bidding for purchasing and selling energy in a power market and a natural gas market on the premise of meeting the internal demand of multiple loads. To solve the internal coordination and optimization problem and the external flexible bidding problem in the multi-energy market, this paper proposes a robust optimization model of energy purchase and sale for the electric–gas interconnection system in a multi-energy market. Firstly, the basic structure of the electric–gas interconnection system is introduced, and the steady-state model of energy flow in the system is built based on the energy hub model. Secondly, considering the uncertainty of energy prices and the output power of renewable energy units in the system, a bidding model for energy purchase and sale of the electric–gas interconnection system in multi-energy market based on the idea of robust optimization is constructed in the framework of the Nordic energy market. Finally, empirical analysis based on the actual data is carried out, and the results prove the validity and superiority of the model. In this paper, aiming at the uncertainty of energy price, a large number of scenes are generated by Latin hypercube sampling (LHS), and then a k-means algorithm is used to reduce the scenes, so as to simulate typical scenes. Aiming at the uncertainty of the output power of the renewable energy unit in the system, a cardinal uncertainty set is used to control deviation between the actual output power and predicted output power, so that the overall robustness of the model can be controlled. The proposed model can make decision-making independent of the accurate probability distribution of uncertainty factors, and is suitable for complex multi energy systems. Meanwhile, the model possesses excellent robustness, which can effectively reduce the risk of bidding loss in the process of energy purchase and sale.
Characterization of type III and IV solar radio bursts from e-CALLISTO

This paper presents the characterization of solar radio burst type III and IV obtained from e-CALLISTO website. Solar radio burst (SRB) is one of the tools in space weather studies as each type of SRB indicates the production of solar activity at that moment which can also bring it towards the prediction of solar events. Generally, SRB has five different type of emissions which are named as type I, II, III, IV and V, this paper will only focus on type III and IV. Data of type III and IV bursts were selected on 15th Sept. 2015 and 27th Feb. 2018 respectively and discussions on each type of bursts include two stations to make a comparison. At the end of this work, type III bursts show a rapidly drift structure from high to low frequency, strongly associated to solar flares and the burst is due to Langmuir waves. Meanwhile, type IV bursts are recognized by its broadband continuum with rapidly fine structure and they act as a hint of geomagnetic storm commencement. More details on the formation of these burst are discussed.
Within- and between-muscle hamstring electromyography activity in various exercises and at different running speeds

Hegyi, András Withinand between-muscle hamstring electromyography activity in various exercises and at different running speeds Jyväskylä: University of Jyväskylä, 2020, 76 p. (JYU Dissertations ISSN 2489-9003; 187) ISBN 978-951-39-8035-1 In the early era of muscle research it was assumed that activation is uniform within muscles. However, recent research revealed regional differences in activation within several muscles, which has been linked to region-specific muscle adaptations to stimuli such as pain, fatigue, and training. Non-uniform withinand between-muscle distribution of hamstring injuries may be linked to non-uniform withinand between-muscle distribution of muscle activity. However, there is a lack of information about regional differences in hamstring muscle activity during hamstring exercises, and in high injury-risk movements such as high-speed running. Therefore, the aim of this thesis was to examine withinand between-muscle differences in biceps femoris and semitendinosus electromyography (EMG) activity using high-density surface EMG in typical hamstring exercises and at different running speeds. Our results showed that in most examined exercises, biceps femoris activity was lowest in the proximal region, which is the region where most hamstring injuries occur. The magnitude of regional differences was exercise-specific. In semitendinosus, some exercises presented uniform EMG activity proximo-distally, while others activated the middle and/or proximal region(s) the most. Generally, knee-oriented movements resulted in larger regional differences than hip-oriented movements in both muscles. Between-muscle differences were exercise-specific, whereby some knee-oriented movements activated semitendinosus preferentially, while hip extension performed on a roman chair activated biceps femoris more than semitendinosus. It was also found that performing Nordic hamstring exercise with hips flexed to 90° shows higher knee flexion torque and lower hamstring EMG activity as compared to performing Nordic hamstring exercise with neutral hips. In running, large inter-individual variability was observed in regional and muscle-specific EMG activity patterns, which were qualitatively consistent across a range of running speeds. These results suggest that a single pair of EMG electrodes placed over biceps femoris or semitendinosus does not accurately describe the activity of the whole muscle. Instead, spatially robust methods such as high-density EMG should be used to comprehensively describe hamstring activity. The sources and consequences of variations in regional activity patterns between exercises and between individuals should be further examined.
Aetiological studies on mixed infection of Abdominal segment deformity disease (ASDD) and Enterocytozoon hepatopenaei (EHP) in cultured Litopenaeus vannamei

Samples of cultured Litopenaeus vannamei showing symptoms of Abdominal Segment Deformity Disease (ASDD) and simultaneously infected by Enterocytozoon hepatopenaei (EHP) collected during the period 2013-2014 from culture ponds of Andhra Pradesh, India were subjected to histopathological, microbiological, molecular and Transmission Electron Microscopic (TEM) studies. Histopathological studies revealed changes such as excessive vacuolization in the gills, sloughing off epithelial layers in the gut, disintegration and lacunae formation in the muscle fibres, degeneration of hepatopancreatic tubules besides haemocytic infiltration into the inter tubular spaces. Spores of Enterocytozoon hepatopenaei (EHP) were found inside the B-cells of hepatopancreas. All the samples were found positive for EHP but IHHNV 50% only. Vibrio harveyi, V. alginolyticus and V. vulnificus were found as associated bacteria. TEM studies confirmed 20-25 nm virus like particles in gill and muscle tissue. This constitutes the first report from India for the mixed infection of ASDD and EHP in cultured L. vannamei.
Analysis and Introduction of Effective Permeability with Additional Air-Gaps on Wireless Power Transfer Coils for Electric Vehicle Based on SAE J2954 Recommended Practice

The wireless power transfer (WPT) method for electric vehicles (EVs) is becoming more popular, and to ensure the interoperability of WPT systems, the Society of Automotive Engineers (SAE) established the J2954 recommended practice (RP). It includes powering frequency, electrical parameters, specifications, testing procedures, and other contents for EV WPT. Specifically, it describes the ranges of self-inductances of the transmitting coil, the receiving coil, and coupling coefficient (k), as well as the impedance matching values of the WPT system. Following the electrical parameters listed in SAE J2954 RP is crucial to ensure the EV wireless charging system is interoperable. This paper introduces a method for adjusting the effective permeability of the ferrite blocks in the standard model, to tune the self-inductance of the coils as well as the coupling coefficient. To guarantee the given values of the self-inductance of the coil and coupling coefficient matched those in the standard, we slightly modified the air-gap between the ferrite tiles in a specific region. Based on this method, it was possible to successfully tune the self-inductance of the transmitting coil and receiving coil as well as the coupling coefficient. The proposed method was verified by simulation and experimental measurements.
The Use of Tunable Optical Absorption Plasmonic Au and Ag Decorated TiO2 Structures as Efficient Visible Light Photocatalysts

Exploring solar-excited heterogeneous photocatalysts by taking advantage of surface plasmon resonance (SPR) has drawn growing research attention. As it could help to pave the way for global sustainable development. The decoration of TiO2 particles with noble metals possessing SPR effects is regarded as one of the most effective solutions. The perfect match of the SPR absorption band with the spectrum of incident light is an essential factor for plasmonic enhancement. However, modifying with sole noble metal is often limited as it tunes wavelength of only several nanometers. To overcome this drawback, an alternative approach can be offered by decoration with more than one noble metal. For instance, Au-Ag co-decoration displays greatly adjustable, composition-dependent SPR agent over a broad range of the visible light spectrum (ca. from 415 to 525 nm). Hence Au-Ag complex is a remarkable candidate for tuning the photo adsorption of TiO2 from UV to visible light. This study presents a novel and tailored method for the fabrication of Au-Ag co-modified TiO2 particles, and how Au-Ag dependent SPR was applied as the visible light-responsive TiO2 based photocatalysts in a simple but reliable way. The fabricated Au-Ag co-decorated TiO2 (AuxAg(1−x)/TiO2) was characterized and proved to own excellent stability and large specific surface area. The optimization of these particles against the wavelength of maximal solar light intensity was confirmed by photo degradation of methylene blue under visible light radiation. This work may provide further insight into the design of TiO2-based composites with improved photocatalytic properties for environmental remediation and renewable energy utilization.
Predictive Quantization for Data Volume Reduction in Staggered SAR Systems

Staggered synthetic aperture radar (SAR) is an innovative SAR acquisition concept which exploits digital beamforming (DBF) in elevation to form multiple receive beams and continuous variation of the pulse repetition interval to achieve high-resolution imaging of a wide continuous swath. Staggered SAR requires an azimuth oversampling higher than an SAR with constant pulse repetition interval (PRI), which results in an increased volume of data. In this article, we investigate the use of linear predictive coding, which exploits the correlation properties exhibited by the nonuniform azimuth raw data stream. According to this, the prediction of each sample is calculated onboard as a linear combination of a set of previous samples. The resulting prediction error is then quantized and downlinked (instead of the original value), which allows for a reduction of the signal entropy and, in turn, of the onboard data rate achievable for a given target performance. In addition, the a priori knowledge of the gap positions can be exploited to dynamically adapt the bit rate allocation and the prediction order to further improve the performance. Simulations of the proposed dynamic predictive block-adaptive quantization (DP-BAQ) are carried out considering a Tandem-L-like staggered SAR system for different orders of prediction and target scenarios, demonstrating that a significant data reduction can be achieved with a modest increase of the system complexity.
Temporal evolution of and factors associated with anemia among women of reproductive age in the state of Pernambuco, Brazil

Anemia is one of the oldest recorded health disorders in history of humanity and still imposes itself as a challenge for collective health in the current world, affecting mainly children, pregnant women and non-pregnant women of reproductive health. The objectives of this cross-sectional study were to analyze the temporal evolution of and factors associated with anemia among women at reproductive age in the state of Pernambuco, Brazil in 1997 and 2006. Material and methods: it included 1.123 (1997) and 1.476 (2006) women aged from 10 to 49 years old. Poisson regression was used to assess associations between anemia and the explanatory variables. The prevalence of anemia in Pernambuco was reduced from 18.7% (1997) to 16.1% (2006), that is, a decline of 13.9%. In contrast, the metropolitan region of Recife (MRR) showed an increase of 6.4%, with higher prevalence in the urban inland and the rural area. Adjusted prevalence ratios showed that only MRR, number of people per household ≥ eight, and having no or one domestic good were kept in the final model. The conclusion is that anemia among women has decreased in Pernambuco and in most socio-economic and biological categories, showing a change of the situation and favoring groups who experience adverse life conditions.
Lack of daily heart rate rhythms in Adélie penguin chicks during the polar day

Abstract Daily rhythms enable organisms to adapt to daily fluctuations in environmental factors. Do organisms still exhibit 24-h rhythms when living in habitats without obvious daily cycles in external signals? To answer this question, we measured the heart rates of six Adélie penguin (Pygoscelis adeliae) chicks on Inexpressible Island during the polar day between 15 and 21 January 2019. Averaged heart rates were between 186 and 233 beats/min for individual chicks. Both fast Fourier transformation and autocorrelation were employed to assess the daily rhythmicity. Based on fast Fourier transformation, a significant contribution of daily rhythm in heart rate variation was found only in one individual. Small effect size of significant autocorrelation coefficients was found in two individuals, while there was no significant autocorrelation coefficient for 24-h time lag in four other individuals. In summary, no prevailing daily rhythm of heart rate was found in these Adélie penguin chicks. We propose that the lack of daily rhythm in Adélie penguin chicks could be an adaptation to the local environment in the polar regions, but that the adaptive value thereof remains to be investigated.