Miracle-dz/UniFAR-FTUs huggingface dataset:
The initial study of industrial competitiveness in accordance with the indicator of the accreditation of environmental management: The case of shoes industry

The International Organization for Standardization (ISO) published the standard of ISO 14001 environment management system in September of 1996. After the publication of ISO 14001, many environmental accreditation systems were developed. Many famous brands developed their environment system, for example, the system of restricted substance limit of Nike. This study focused on the supply chain of shoes industry to research that how the environmental management system were maintained and what were their approaches to saved energies, reduced the production cost and passed the environment accreditation. In this study, we interviewed one shoe factory, five leather tanneries, and also finished a survey of 15 leather tanneries, as the result, they all passed the ISO 14001 or the Leather World Group accreditation which are required by many worldwide athlete brands. This study found that the environmental accreditation became a basic element to become more competitive, however it is not the guarantee for new order. However in the process to have the environment system, the leather tannery not only fulfilled the management system to achieve the synergy of quality, reduction of the material loss and power energy, and water resource saving. In this fashion, they are not only enhanced the satisfaction of customer but also reduced the cost of production and strengthen their competitiveness.
Neuropsychological deficits associated with heavy prenatal alcohol exposure are not exacerbated by ADHD.

OBJECTIVE Neuropsychological functioning of individuals with attention-deficit/hyperactivity disorder (ADHD) or heavy prenatal alcohol exposure has been well documented independently. This study examined the interaction between both factors on cognitive performance in children. METHOD As part of a multisite study, 344 children (8-16 y, M = 12.28, SD = 2.52) completed a comprehensive neuropsychological battery. Four subject groups were tested: children with histories of heavy prenatal alcohol exposure (AE) and ADHD (AE+, n = 90), alcohol-exposed without ADHD, (AE-, n = 38), nonexposed with ADHD (ADHD, n = 80), and nonexposed without ADHD (CON, n = 136). RESULTS Separate 2(AE) × 2(ADHD) MANCOVAs revealed significant main and interactive effects of ADHD and AE on overall WISC-IV, D-KEFS, and CANTAB performance. Individual ANOVAs revealed significant interactions on 2 WISC-IV indices [Verbal Comprehension (VCI), Perceptual Reasoning (PRI)], and four D-KEFS and CANTAB subtests [Design Fluency, Verbal Fluency, Trail Making, Spatial Working Memory]. Follow-up analyses demonstrated no difference between AE+ and AE- groups on these measures. The combined AE+/- group demonstrated more severe impairment than the ADHD group on VCI and PRI, but there were no other differences between clinical groups. CONCLUSIONS These results support a combined AE+/- group for neuropsychological research and indicate that, in some cases, the neuropsychological effects seen in ADHD are altered by prenatal alcohol exposure. The effects of alcohol exposure on verbal comprehension and perceptual reasoning were greater than those related to having ADHD without alcohol exposure, although both conditions independently resulted in cognitive impairment compared to controls. Clinically, these findings demonstrate task-dependent patterns of impairment across clinical disorders.
Environmental exposures, genetic predisposition and allergic diseases: one size never fits all

A remarkable increase in the prevalence of allergic diseaseappears to parallel the postindustrial lifestyle changes inwesternized societies. Insuﬃcient microbial exposureduring infancy and early childhood is one of the proposedexplanations for the increase in prevalence of atopicsensitization and associated clinical phenotypes (asthma,allergic rhinitis, eczema). Within this context, childhoodvaccination may be associated with an increased risk ofallergies [e.g. children whose parents refuse the vaccin-ation have less atopic diseases (1)]. However, it has to beemphasized that major beneﬁts of childhood vaccinationprogrammes and successes in the prevention and treat-ment of infectious diseases (with global reduction inmortality and morbidity) clearly outweigh the risk of thepossible promoting eﬀect on allergic disease.There is growing evidence that one of the inadvertentconsequences of the ﬁght against infectious diseases andour obsession with cleanliness might have been theinterference with the immune system development. Thechanging pattern of microbial exposure, with the declinein some infectious diseases, may lead to a slowermaturation of the immune system, with a delayeddevelopment of the optimally balanced immune re-sponses. This notion forms the immunological basis ofthe hygiene hypothesis. However, the hygiene hypothesisoriginated from epidemiological studies.Searching for the cause of allergy: the link between epidemiologyand immunologyFamily size. The pioneering proposal by David Strachanthat a decrease in family size reduced the possibility ofcross-infections, facilitating the clinical expression ofallergic rhinitis had lead to intense interest in this area(2). His ﬁndings were conﬁrmed in a number of studies(3), and within the same context, exposure to otherchildren in day-care centres was found to be protectiveagainst asthma and atopy (4). Yet, the eﬀects of familysize, position in sibship or day-care arrangements maynot be mediated by the exposure to infectious agents,but some other underlying aspect of immune response(5). Helminths. Children in developing countries who areinfested with helminths are less likely to develop atopyand allergic disease. Furthermore, long-term treatment ofintestinal helminths in infested children increases speciﬁcsensitization to house dust mite (6). In addition, thereappears to be an inverse dose-response relationshipbetween the burden of infestation by helminths andexpression of allergic disease (7). However, helminthsmay only be a marker of environmental exposure to othermicrobial agents and/or endotoxin.Helminthic infections enhance the secretion of T
Monte Carlo Tree Search guided by Symbolic Advice for MDPs

In this paper, we consider the online computation of a strategy that aims at optimizing the expected average reward in a Markov decision process. The strategy is computed with a receding horizon and using Monte Carlo tree search (MCTS). We augment the MCTS algorithm with the notion of symbolic advice, and show that its classical theoretical guarantees are maintained. Symbolic advice are used to bias the selection and simulation strategies of MCTS. We describe how to use QBF and SAT solvers to implement symbolic advice in an efficient way. We illustrate our new algorithm using the popular game Pac-Man and show that the performances of our algorithm exceed those of plain MCTS as well as the performances of human players.
Linkage of Replication to Start by the Cdk Inhibitor Sic1

In Saccharomyces cerevisiae, three G1 cyclins (Clns) are important for Start, the event committing cells to division. Sic1, an inhibitor of Clb-Cdc28 kinases, became phosphorylated at Start, and this phosphorylation depended on the activity of Clns. Sic1 was subsequently lost, which depended on the activity of Clns and the ubiquitin-conjugating enzyme Cdc34. Inactivation of Sic1 was the only nonredundant essential function of Clns, because a sic1 deletion rescued the inviability of the cln1 cln2 cln3 triple mutant. In sic1 mutants, DNA replication became uncoupled from budding. Thus, Sic1 may be a substrate of Cln-Cdc28 complexes, and phosphorylation and proteolysis of Sic1 may regulate commitment to replication at Start.
Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection.

OBJECTIVE To evaluate the prevalence and seasonality of human respiratory syncytial virus (HRSV) in children aged 0 to 6 years, hospitalized with acute lower respiratory infection (ALRI) in São José do Rio Preto, SP, Brazil, and the association between age, diagnosis, and HRSV. METHODS Between May 2004 and September 2005, we studied 290 consecutive episodes of community-acquired ALRI in children aged 0 to 6 years admitted to the Hospital de Base of São José do Rio Preto. In order to detect HRSV, nasopharyngeal secretion samples were collected and RT-PCR molecular analysis was performed. RESULTS The HRSV prevalence was 29.3% for the cases of hospitalized patients with ALRI. ALRI was common in infants (median age = 13.5 months). HRSV was more frequent in cases of bronchiolitis (64%) and during the first year of life (35%). Episodes of HRSV infection occurred between fall and spring, showing higher frequency in 2004 than in 2005. Clinical and radiological criteria were not sufficient to establish the diagnosis of infection with HRSV. Antibiotic therapy was used in 78.8% of episodes of HRSV. CONCLUSIONS There was a high prevalence of HRSV in children aged 0 to 6 years who were hospitalized for ALRI, predominantly in younger patients or those with bronchiolitis. The circulation of the virus varied in the two years studied. Our results suggest the need for laboratory diagnosis of HRSV in the clinical practice.
Circulating tumor cells in metastatic breast cancer: biologic staging beyond tumor burden.

BACKGROUND The detection of circulating tumor cells (CTCs) predicts overall survival in patients with metastatic breast cancer (MBC). However, it is unknown whether CTCs have superior value compared with other standard prognostic factors. We compared the prognostic significance of CTCs with clinical and laboratory measures of tumor burden and phenotypic subtype of disease. PATIENTS AND METHODS One hundred fifty-one patients with MBC evaluated between 2000 and 2006 were included in this retrospective analysis. Circulating tumor cells were isolated and enumerated in whole blood using an immunomagnetic bead system (CellSearch System). Overall survival was evaluated according to the level of CTCs (negative: <5 CTCs per 7.5 mL of blood; positive: >or=5 CTCs per 7.5 mL of blood), Swenerton score, cancer antigen 27-29 level, age (<50 years vs. >or=50 years), hormone-receptor status and HER2 status, metastatic site, and type and line of therapy. RESULTS The median age of patients was 53 years (range, 24-88 years), and 44% of the patients had >5 CTCs. The median overall survival for negative versus positive CTCs were 29.3 months and 13.5 months, respectively (P<0.0001). In the multivariable Cox model, the detection of>or=5 CTCs demonstrated the highest hazard ratio with 2.2 times the risk of death (P=0.003). The prognostic value was independent of measure of tumor burden and type and line of therapy, and phenotypic subtype of the disease. CONCLUSION Circulating tumor cells have superior and independent prognostic value of tumor burden and disease phenotype and might represent an important marker of tumor biology in MBC. Detection of CTCs should be considered for new staging stratification of patients with MBC.
Inverse of Lorentzian Mixture for Simultaneous Training of Prototypes and Weights

This paper presents a novel distance-based classifier based on the multiplicative inverse of Lorentzian mixture, which can be regarded as a natural extension of the conventional nearest neighbor rule. We show that prototypes and weights can be trained simultaneously by General Loss Minimization, which is a generalized version of supervised learning framework used in Generalized Learning Vector Quantization. Experimental results for UCI machine learning repository reveal that the proposed method achieves almost the same as or higher classification accuracy than Support Vector Machine with a much fewer prototypes than support vectors.
Impact des informations sémantiques sur la catégorisation automatique des documents cliniques

Coding of discharge summaries is performed in hospitals daily. We propose to study the impact the use of semantic information may have on this coding. The complementarity of structured medical terminology and medication resource is evaluated on a collection of 1,237 discharge summaries. Performances of the system are improved with the specialization of terminological data.
Weight gain management in patients with schizophrenia during treatment with olanzapine in association with nizatidine.

OBJECTIVE Weight gain is associated with treatment with many psychotropic agents. Nizatidine, H2 receptor antagonist, has been proposed to have weight-reducing effects. This was a 12-week, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of nizatidine in reducing/limiting weight gain in patients with schizophrenia who have been under treatment with olanzapine. METHOD Patients receiving olanzapine (2 to 6 months) and weight gain >or= 5% of their body weight during olanzapine treatment were randomly assigned to receive nizatidine 600 mg or placebo for up to 12 weeks. Change in psychopathology was assessed using Brief Psychiatric Rating Scale scores from baseline to endpoint. Safety was assessed using the Safety Assessed Software, assessment of glucose and lipid blood levels, and treatment-emergent adverse events. RESULTS Out of 54 patients enrolled in this analysis, 45 completed the protocol. The mean weight change prior randomization was 7.6 kg and 7.3 kg for those randomized to placebo and nizatidine, respectively (p = 0.828). Patients receiving placebo and nizatidine had a mean weight gain of 12.3% (0.7 kg) and 12% (1.1 kg) from baseline to endpoint, respectively (p = 0.9). Patients from both groups experienced a statistically significant decrease on the Brief Psychiatric Rating Scale mean score from baseline to endpoint. Treatment-emergent adverse events were reported by 18.5% and 25.9% on the placebo and nizatidine group, respectively. There were no statistically significant differences in glucose and lipid blood levels from baseline to endpoint and between groups. CONCLUSIONS The concomitant use of olanzapine with nizatidine was not effective in controlling weight gain in patients who had previously gained weight during treatment with olanzapine when compared to placebo.
Impact of a Hospital Palliative Care Service: Perspective of the Hospital Staff

The first New Zealand hospital palliative care support service was established in 1985. Different service models have now been adopted by various major hospitals. In 1998, a palliative care service, funded by Mary Potter Hospice, was piloted at Wellington Public Hospital. Twelve months post-implementation, the hospital staff's views of the service were evaluated. It was found that referrals to palliative care from hospital specialities outside the Cancer Centre increased. While most doctors, nurses and social workers strongly agreed or agreed that the service positively influenced patients’ care and effectively addressed their symptom management needs, spiritual needs were less often met. Over 90 percent of each discipline strongly agreed or agreed that the service had assisted them in caring for patients, but, only about a half agreed that useful discharge planning advice and staff support was provided. Significant differences in responses were found between different disciplines and specialities. One fifth of the staff identified palliative care education needs. Recommendations are made concerning the development of a future hospital palliative care service.
Medical Technologies and the Dream of the Perfect Newborn

Feminist and disability scholars have critiqued the role of prenatal testing technologies in fostering parental expectations to give birth to “perfect” children. However, in the case of postnatal screening for genetic disorders, identifying large numbers of asymptomatic infants brings previously hidden imperfections into critical relief. Consequently, newborn screening technologies have altered the day-to-day landscape of early childrearing and development for many families. Drawing on ethnographic fieldwork in a California pediatric genetics clinic, we describe how newborn screening creates ambiguous forms of biogenetic abnormality, foreshadowing a life of incipient disorder for children, families, and health care providers and so destabilizing parents' hopes of having a healthy child. By demonstrating key points of convergence and divergence between the social consequences of prenatal and postnatal screening, we expand the analytic gaze on reproductive technologies and establish newborn screening as a vibrant locus of inquiry for the anthropology of reproduction.
Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia.

BACKGROUND Vulvar intraepithelial neoplasia is a chronic disorder caused by high-risk types of human papillomavirus (HPV), most commonly HPV type 16 (HPV-16). Spontaneous regression occurs in less than 1.5% of patients, and the rate of recurrence after treatment is high. METHODS We investigated the immunogenicity and efficacy of a synthetic long-peptide vaccine in women with HPV-16-positive, high-grade vulvar intraepithelial neoplasia. Twenty women with HPV-16-positive, grade 3 vulvar intraepithelial neoplasia were vaccinated three or four times with a mix of long peptides from the HPV-16 viral oncoproteins E6 and E7 in incomplete Freund's adjuvant. The end points were clinical and HPV-16-specific T-cell responses. RESULTS The most common adverse events were local swelling in 100% of the patients and fever in 64% of the patients; none of these events exceeded grade 2 of the Common Terminology Criteria for Adverse Events of the National Cancer Institute. At 3 months after the last vaccination, 12 of 20 patients (60%; 95% confidence interval [CI], 36 to 81) had clinical responses and reported relief of symptoms. Five women had complete regression of the lesions, and HPV-16 was no longer detectable in four of them. At 12 months of follow-up, 15 of 19 patients had clinical responses (79%; 95% CI, 54 to 94), with a complete response in 9 of 19 patients (47%; 95% CI, 24 to 71). The complete-response rate was maintained at 24 months of follow-up. All patients had vaccine-induced T-cell responses, and post hoc analyses suggested that patients with a complete response at 3 months had a significantly stronger interferon-gamma-associated proliferative CD4+ T-cell response and a broad response of CD8+ interferon-gamma T cells than did patients without a complete response. CONCLUSIONS Clinical responses in women with HPV-16-positive, grade 3 vulvar intraepithelial neoplasia can be achieved by vaccination with a synthetic long-peptide vaccine against the HPV-16 oncoproteins E6 and E7. Complete responses appear to be correlated with induction of HPV-16-specific immunity.
Risk of falls, injurious falls, and other injuries resulting from visual impairment among older adults with age-related macular degeneration.

PURPOSE Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment among older adults. This study explored the relationship between AMD, fall risk, and other injuries and identified visual risk factors for these adverse events. METHODS Participants included 76 community-dwelling individuals with a range of severity of AMD (mean age, 77.0 ± 6.9 years). Baseline assessment included binocular visual acuity, contrast sensitivity, and merged visual fields. Participants completed monthly falls and injury diaries for 1 year after the baseline assessment. RESULTS Overall, 74% of participants reported having either a fall or a non-fall-related injury. Fifty-four percent of participants reported a fall and 30% reported more than one fall; of the 102 falls reported, 63% resulted in an injury. Most occurred outdoors (52%), between late morning and late afternoon (61%) and when navigating on level ground (62%). The most common non-fall-related injuries were lacerations (36%) and collisions with an object (35%). Reduced contrast sensitivity and visual acuity were associated with increased fall rate, after controlling for age, sex, cognitive function, cataract severity, and self-reported physical function. Reduced contrast sensitivity was the only significant predictor of non-fall-related injuries. CONCLUSIONS Among older adults with AMD, increased visual impairment was significantly associated with an increased incidence of falls and other injuries. Reduced contrast sensitivity was significantly associated with both increased rates of falls and other injuries, while reduced visual acuity was only associated with increased fall rate. These findings have important implications for the assessment of visually impaired older adults.
Database Modelling Using WSML in the Specification of a Banking Application

—We demonstrate through a sample application, E-banking, that the Web Service Modelling Language Ontology component can be used as a very powerful object-oriented database design language with logic capabilities. Its conceptual syntax allows the deﬁnition of class hierarchies, and logic syntax allows the deﬁnition of constraints in the database. Relations, which are available for modelling relations of three or more concepts, can be connected to logical expressions, allowing the implicit speciﬁcation of database content. Using a reasoning tool, logic queries can also be made against the database in simulation mode.
Alteraciones citopatológicas del Cervix en trabajadoras sexuales y sus factores asociados

Introduccion: La prostitucion es una actividad lucrativa que desempenan tanto hombres como mujeres para obtener sustento economico que pueda solventar su situacion economica, con riesgos inherentes como transmision de enfermedades sexuales, y la infeccion por virus de papiloma humano entre otras. Se pretendio conocer las alteraciones citopatologicas del cervix en una muestra de trabajadoras sexuales en el distrito capital y cuales son sus factores asociados. Metodologia: Se realizo un estudio transversal. Se realizaron encuestas sociodemograficas y se analizaron los resultados de CCV. Adicionalmente se establecieron los factores de riesgo asociados a ASC-US mediante pruebas de chi cuadrado y Mann Whitney. Resultados: Se incluyeron un total de 102 trabajadoras, la mediana de edad fue 30 anos, la frecuencia de alteraciones citopatologicas (ASC-US) fue de 8.8% (n=9). No se encontraron casos de neoplasia ni alteraciones del cervix de las celulas glandulares. El 81% usa preservativo en el ejercicio de la prostitucion, ninguna paciente esta vacunada contra VPH. Discusion: Tomando en cuenta la baja prevalecia de alteraciones en la citologia cervicovaginal encontradas en las trabajadoras sexuales que fueron estudiadas se cuestiona esta prueba como tamizaje para una poblacion en tan alto riesgo de contraer VPH y desarrollar alteraciones citologicas de cuello uterino. estudios futuros deberan centrar su interes en determinar la concordancia que existe entre la CCV y pruebas mas sensibles y especificas para la determinacion de VPH de alto riesgo como la PCR asi como tambien determinar las causas de los falsos negativos que tiene la CCV, dichos estudios serviran como base para tomar decisiones de salud publica frente a al tamizacion y seguimiento de las trabajadoras sexuales las cuales son un grupo de mujeres que se encuentran alto riesgo de desarrollar alteraciones citologicas a nivel del cervix.