Miracle-dz/UniFAR-FTUs huggingface dataset:
Hierarchical Requirement of SWI/SNF in Retinoblastoma Tumor Suppressor-mediated Repression of Plk1*

Plk1 (Polo-like kinase 1) is a critical regulator of cell cycle progression that harbors oncogenic activity and exhibits aberrant expression in multiple tumors. However, the mechanism through which Plk1 expression is regulated has not been extensively studied. Here we demonstrate that Plk1 is a target of the retinoblastoma tumor suppressor (RB) pathway. Activation of RB and related pocket proteins p107/p130 mediate attenuation of Plk1. Conversely, RB loss deregulates the control of Plk1 expression. RB pathway activation resulted in the repression of Plk1 promoter activity, and this action was dependent on the SWI/SNF chromatin remodeling complex. Although SWI/SNF subunits are lost during tumorigenesis and cooperate with RB for transcriptional repression, the mechanism through which SWI/SNF impinges on RB action is unresolved. Therefore, we delineated the requirement of SWI/SNF for three critical facets of Plk1 promoter regulation: transcription factor binding, corepressor binding, and histone modification. We find that E2F4 and pocket protein association with the Plk1 promoter is independent of SWI/SNF. However, these analyses revealed that SWI/SNF is required for histone deacetylation of the Plk1 promoter. The importance of SWI/SNF-dependent histone deacetylation of the Plk1 promoter was evident, because blockade of this event restored Plk1 expression in the presence of active RB. In summary, these data demonstrate that Plk1 is a target of the RB pathway. Moreover, these findings demonstrate a hierarchical role for SWI/SNF in the control of promoter activity through histone modification.
The High Performance Working Practices in Romanian Companies – an Empirical Study

The modern companies are facing an economical background marked by an intense competition. Therefore, the struggle to enhance the performance’s level became a major task for the management that brings into discussion the importance of high performance working systems. There are various approaches on this issue in the specialized literature. The practices implied by such systems are tightly connected with the human resources management practices that the companies are using in order to ensure their success and development This paper aims to investigate the presence of these specific practices such as recruitment and career management, training, variable payment schemes, in companies situated in Constanta county, Romania. The analysis is based on the results of an empirical study and tries to establish the level of development of such practices in the studied companies and the potential correlation between them and the size of the analyzed companies.
A loss optimized and cost effective droop control scheme for a DC microgrid integrated with a weak rural distribution grid

In this paper, a loss optimized and cost effective droop control scheme is proposed for a DC microgrid coupled to a weak rural distribution grid. The active power exchange limits between the DC microgrid and the utility grid have been derived considering the Indian voltage regulation standards as set by Central Electricity Authority at the point of common coupling. In the grid-connected mode, the DC microgrid is connected to the utility grid via a bidirectional interfacing converter (BIC). The proposed scheme ensures an optimal operation of battery energy storage converter (BESC) and BIC in terms of loss and cost. The scheme employs a dedicated communication link based on controller area network (CAN) protocol making the system operation smarter and intelligent. The method guarantees the maintenance of the DC bus voltage at the nominal value under all operating scenarios. The performance of the control scheme has been validated with experiments. Case by case experimental results included.
Underemployment and well-being in the UK before and after the Great Recession

Since the start of the economic crisis in 2008 there has been widespread concern with changes in the level and composition of unemployment. The phenomenon of underemployment has, however, received markedly less attention, although it too increased in extent following the start of the crisis. This article considers the consequences of underemployment for the subjective well-being of UK employees. Drawing on data from the 2006 and 2012 Employment and Skills Surveys, the article assesses how the Great Recession affected relationships between different dimensions of underemployment and well-being. The findings demonstrate that the negative well-being consequences of workers’ dissatisfaction with opportunities to make use of their abilities became more substantial, as did the consequences of being ‘hours constrained’ and having an unsatisfactory workload. The article also shows that the economic crisis had a negative impact on the well-being of employees who work very long hours.
Identifying the 'right' supplier for module developments-a cross-industrial case analysis

Relational view argues that buying companies should integrate supplier resources in new product development (NPD) projects to realise competitive advantages. Due to decoupling of modules and the associated opportunity to allocate development activities to upstream suppliers, modular product architectures are considered to be a driving factor for the integration of supplier resources. Module developments are associated with substantial investments, long-term orientation and risks across product families for the buying firm. Therefore, supplier integration for module development is highly critical. Regardless of the relevance, research has not yet analysed, which supplier competence are considered as antecedents for successful module developments with suppliers. To close the identified gap, this paper analysed case companies from the automotive, agriculture equipment and rail vehicle industry. Technical, organisational and relationship aspects are identified as critical success factors. The results contribute to theory by adding to relational view the finding that competences for successful collaborations differ in accordance to the level of interaction between suppliers and buying firms. Moreover, this study provides a model and an evaluation scheme that helps practitioners to allocate the best suitable development role to suppliers within module developments.
Examining the Relationships Between Diversity and Work Behaviors in U.S. Federal Agencies: Does Inclusive Management Make a Difference?

Workforce diversity has been depicted as a double-edged sword that leads to both positive and negative work-related outcomes. As a result, the critical issue in diversity research is concerned with enhancing the benefits and reducing the detriments of heterogeneity within organizations on work behaviors. By combining theories on diversity and inclusiveness, this article examines inclusive management at the federal subagency level as a moderator of the relationships between demographic diversity (gender and race) and work behaviors (innovative and turnover behavior). Using survey and personnel data drawn from federal subagencies, inclusive management—a set of policies aimed at recognizing all employees as valued organizational insiders with unique identities—not only strengthens the positive relationship between racial diversity and innovative behavior but also attenuates the positive relationship between gender diversity and turnover behavior. These findings suggest that inclusive management is a key strategy for effectively managing diversity.
Prostaglandin F2 a regulates the expression of uterine activation proteins via multiple signalling pathways

Prostaglandin F2 a (PGF2A) has multiple roles in the birth process in addition to its vital contractile role. Our previous study has demonstrated that PGF2A can modulate uterine activation proteins (UAPs) in cultured pregnant human myometrial smooth muscle cells (HMSMCs). The objective of this study was to deﬁne the signalling pathways responsible for PGF2A modulation of UAPs in myometrium. It was found that PGF2A stimulated the expression of (GJA1) connexin 43 (CX43), prostaglandin endoperoxide synthase 2 (PTGS2) and oxytocin receptor (OTR) in cultured HMSMCs. The inhibitors of phospholipase C (PLC) and protein kinase C (PKC) blocked PGF2A-stimulated expression of CX43. The inhibitors of ERK, P38 and NF k B also blocked the effect of PGF2A on CX43 expression, whereas PI3K and calcineurin/nuclear factor of activated T-cells (NFAT) pathway inhibitors did not reverse the effect of PGF2A on CX43. For PTGS2 and OTR, PLC, PI3K, P38 and calcineurin/NFAT signalling pathways were involved in PGF2A action, whereas PKC and NF k B signalling were not involved. In addition, PGF2A activated NFAT, PI3K, NF k B, ERK and P38 signalling pathways. Our data suggest that PGF2A stimulates CX43, PTGS2 and OTR through divergent signalling pathways.
Compact dual-band microstrip patch array antenna for MIMO 4G communication systems

In this paper, a compact dual-band microstrip patch array antenna for both the MIMO 4G LTE and the WLAN systems is developed. Design simulation and optimization processes are carried out with the aid of the Advanced Design System (ADS) electromagnetic simulator that uses the full–wave Method of Moment (MoM) numerical technique [1]. The losses that are caused by both the substrate and metallization are taken into account during the simulation process. Array compactness was our target during the design process to integrate the array with the new mobile communication equipments.
Product review on the monoclonal antibody palivizumab for prevention of respiratory syncytial virus infection

ABSTRACT Respiratory syncytial virus (RSV) accounts for about 20% of all respiratory infections in children below the age of 5 y. It is associated with up to 63% of all acute respiratory infections and up to 81% of all viral lower respiratory tract infections causing hospitalization in infants and young children. RSV leads to seasonal epidemics between November and April in the northern hemisphere. Most severe infections (RSV accounts for 50 to 80% of all cause bronchiolitis) affect infants younger than 6 months of age and high-risk infants including those born preterm with or without bronchopulmonary dysplasia and those with hemodynamically significant congenital heart disease up to an age of 24 months. Palivizumab, a highly potent RSV-neutralizing monoclonal antibody (Mab), has been licensed in 1998 for prophylactic use to prevent RSV associated hospitalizations in high-risk infants. This Mab is given by monthly intramuscular injection at a dose of 15 mg/kg over the RSV season (up to 5 times). Palivizumab proved to be safe and well-tolerated in this population. Concerns have been raised regarding cost-effectiveness of palivizumab and thus, palivizumab prophylaxis is mainly limited to selected high-risk infants for the first RSV season. Long-lasting Mabs will be the next future approach in the prophylaxis of RSV hospitalization until a vaccine is developed.
Polymorphism in the E6 gene of human papillomavirus type 16 in the cervical tissues of Korean women

The aim of this study was to identify sequence variants in the HPV 16 E6 gene in Korean women and to examine the possible association between these sequence variants and cervical cancer development. We examined the HPV 16 DNA of 215 patients with no cervical disease (NCD) (n = 105) or with cervical neoplasia (n = 110) [cervical intraepithelial neoplasia (CIN), n = 61; invasive cervical carcinoma (ICC), n = 49] using the nested polymerase chain reaction (PCR) and PCR-directed sequencing methods. Fifty-four (NCD, n = 10; CIN, n = 17; ICC, n = 27) of the 215 samples contained HPV 16 E6 DNA, but only two (7.4%) of 27 ICC samples had prototype sequences. The most frequently found variation was D25E (in NCD, n = 8, 80%; in CIN, n = 9, 52.9%; in ICC, n = 23, 85.2%). This is a rare variation in western countries. No significance difference was found between the frequencies of D25E variation in cancerous and non-cancerous lesions. Among the 11 kinds of variants identified, four variants were novel and have been registered with GenBank. This study demonstrates that the D25 variant is the most prevalent E6 genomic variant type in Korean population. However, it was not found to be associated with an increased risk of ICC.
Peripherally inserted veno-venous ultrafiltration for rapid treatment of volume overloaded patients.

BACKGROUND Veno-venous ultrafiltration may benefit patients with acute or chronic circulatory volume overload. Use of conventional systems, however, may be cumbersome, requiring physician placement of a double-lumen central venous catheter and use of a dedicated dialysis technician and apparatus. METHODS A simplified peripheral ultrafiltration system including a miniaturized disposable circuit was evaluated in patients with volume-overload states. Separate intravenous catheters (16-18 G) for withdrawal and return of blood (blood flow <or= 40 mL/min, ultrafiltrate <or= 500 mL/h) were placed by nonphysician personnel in upper extremity veins. Twenty-five treatments of up to 8 hours were performed in 21 patients. RESULTS The primary endpoint of greater than 1 L fluid removal in less than 8 hours was achieved in 23 of 25 treatments. On average, 2611 +/- 1002 mL (maximum 3,725 mL) of ultrafiltrate was removed per treatment (treatment period 6:43 +/- 1:47 hours:minutes). Patient weight decreased from 91.9 +/- 17.5 to 89.3 +/- 17.3 kg (P <.0001) after ultrafiltration. No major adverse events occurred. CONCLUSIONS Rapid removal of extracellular and intravascular fluid volume excess can be safely achieved via peripherally inserted ultrafiltration without the need for central venous catheter placement.
Cumulative-genetic plasticity, parenting and adolescent self-regulation.

BACKGROUND The capacity to control or regulate one's emotions, cognitions and behavior is central to competent functioning, with limitations in these abilities associated with developmental problems. Parenting appears to influence such self-regulation. Here the differential-susceptibility hypothesis is tested that the more putative 'plasticity alleles' adolescents carry, the more positively and negatively influenced they will be by, respectively, supportive and unsupportive parenting. METHODS One thousand, five hundred and eighty-six (1586) adolescents (n = 754 males; n = 832 females) enrolled in the American Add Health project were scored in terms of how many of 5 putative 'plasticity alleles' they carried - the 10R allele of DAT1, the A1 allele of DRD2, the 7R allele of DRD4, the short allele of 5HTTLPR, and the 2R/3R alleles of MAOA. Then the effect of the resultant index (ranging from 0 to 5) of cumulative-genetic plasticity in moderating effects of parenting on adolescent self-regulation was evaluated. RESULTS Consistent with differential susceptibility, the more plasticity alleles males (but not females) carried, the more and less self-regulation they manifested under, respectively, supportive and unsupportive parenting conditions. CONCLUSION Adolescent males appear to vary for genetic reasons in their susceptibility to parenting vis-à-vis self-regulation, perhaps due to epistatic and/or epigenetic processes. G×E research may benefit from compositing candidate genes. To afford comparative evaluation of differential-susceptibility vs. diathesis-stress models of environmental action, future G×E work should focus on positive as well as negative environmental conditions and developmental outcomes.
Alfentanil infusion for postoperative pain: a comparison of epidural and intravenous routes.

The efficacy of intravenous (iv) and epidural infusions of alfentanil for postoperative pain relief was investigated in 24 patients (ASA physical status 1-2) who were scheduled for abdominal hysterectomy. The patients were allocated randomly to receive either epidural or iv alfentanil. In both groups, a loading dose of 15 micrograms.kg-1 was administered, followed by a constant rate infusion of 18 micrograms.kg-1.h-1 alfentanil for 20 h. Both routes provided similar degrees of analgesia; however, analgesia occurred earlier in the intravenously treated group (P less than 0.03). Mean plasma alfentanil concentrations (Cps) varied between 42 and 82 ng.ml-1 in the iv group and 23 and 68 ng.ml-1 in the epidural group, with higher concentrations in the iv group for the first 60 min only (P less than 0.01). Cps increased with infusion time, suggesting accumulation of alfentanil. After infusion ended, pain recurred at the same time in both groups, whereas the alfentanil Cps still were greater than 45 ng/ml. Postoperative epinephrine concentrations decreased after 60 min of infusion (P less than 0.02), whereas, after 6 h, cortisol levels decreased to preoperative values. Norepinephrine concentrations decreased only slightly. The only clinically meaningful effect on vital signs that occurred was an abrupt reduction of respiratory rate after the iv loading dose. PaCO2 increased to the same extent in both groups during the first 15 min only. The incidence of opioid-related side effects was similar in both groups. These results suggest that the iv and epidural routes were equally effective for providing postoperative pain control and controlling the postoperative response to surgical stress.
Blockade of the Noradrenaline Carrier Increases Extracellular Dopamine Concentrations in the Prefrontal Cortex: Evidence that Dopamine Is Taken up In Vivo by Noradrenergic Terminals

Abstract: The effect of systemic administration of desmethylimipramine (DMI) and oxaproptiline (OXA), two inhibitors of the noradrenaline (NA) reuptake carrier, on the in vivo extracellular concentrations of dopamine (DA) was studied by transcerebral dialysis in the prefrontal cortex and in the dorsal caudate of freely moving rats. In the NA‐rich prefrontal cortex, either drug increased extracellular DA concentrations whereas in the dorsal caudate neither was effective. Haloperidol increased extracellular DA concentrations more effectively in the dorsal caudate than in the prefrontal cortex. Pre‐treatment with DMI or OXA. which failed to modify the effect of haloperidol in the dorsal caudate, potentiated its action in the prefrontal cortex. 6‐Hydroxydopamine lesioning of the dorsal NA bundle prevented the ability of OXA to increase DA concentrations. The results suggest that reuptake into NA terminals is an important mechanism by which DA is cleared from the extracellular space in a NA‐rich area such as the prefrontal cortex. The elevated extracellular concentrations of DA resulting from blockade of such mechanism by tricyclic antidepressants may play a role in the therapeutic effects of these drugs.
TRADING BASED ON KNOWING THE WASDE REPORT IN ADVANCE

Abstract Past research shows that prices move in response to World Agricultural Supply and Demand Estimates (WASDE) reports immediately prior to and after a report. This research develops trading models based on knowing the next WASDE report in advance. This should help traders evaluate investments to predict information contained within the report and in determining how best to use such forecasts. The price-forecasting models use regressions against the ratios of ending stocks to use. Results show a steady increasing return to trading over the report month. The highest returns are produced by trading during the growing and harvest seasons.
The Effectiveness of Usage of Online Multiple Choice Questions on Student Performance in Introductory Accounting

ABSTRACT: In this paper we investigate the effectiveness of an online learning resource for introductory financial accounting students using a suite of online multiple choice questions (MCQ) for summative and formative purposes. We found that the availability and use of an online resource resulted in improved examination performance for those students who actively used the online learning resource. Further, we found a positive relationship between formative MCQ and unit content related to challenging financial accounting concepts. However, better examination performance was also linked to other factors, such as prior academic performance, tutorial participation, and demographics, including gender and attending university as an international student. JEL Classifications: I20; M41.
Investigating wellness tourists’ motivation, engagement, and loyalty: in search of the missing link

ABSTRACT Wellness tourism is a rapidly growing sector of the current thriving tourism industry. The purpose of this study was to investigate tourists’ motivation and its relationship with engagement and loyalty at wellness tourism destinations. Specifically, tourists’ motivation was evaluated via four components: prestige and luxury; novelty and knowledge; self-development; and relaxation and escape. Tourists’ engagement was assessed from two perspectives: experiential and reflective. The study confirmed the impact of tourists’ motivation on engagement, which consequently leads to loyalty. The present research provides industry practitioners with strategies to understand and predict tourists’ behavior in wellness tourism destinations.
Local and National Democracy in Political Reconstruction

After conflict or breakdown of the state, successful democratic development will require an ample supply of leaders who have good reputations for responsible public service that can benefit all citizens. This essential supply of trusted democratic leadership can develop in responsible institutions of democratic local government, where successful local leaders can prove their qualifications to compete for higher office. If a transition to democracy begins with only national elections, however, then the winners will acquire a natural interest in centralizing power around themselves, and so political decentralization thereafter may become more difficult. Thus, those who would support the development of a new democracy need to recognize the potential advantages of decentralizing some power to elected local governments.
Case-control study to evaluate predictors of lymphedema after breast cancer surgery.

PURPOSE/OBJECTIVES To identify risk factors for lymphedema after breast cancer surgery. DESIGN Multisite case-control study. SETTING Lymphedema clinics in the upper midwestern region of the United States. SAMPLE 94 patients with lymphedema and 94 controls without lymphedema, matched on type of axillary surgery and surgery date. METHODS The Measure of Arm Symptom Survey, a patient-completed tool, assessed potential risk factors for lymphedema. Severity of lymphedema was measured by arm circumference, and disease and treatment factors were collected via chart review. MAIN RESEARCH VARIABLES Risk factors for lymphedema after breast cancer surgery. FINDINGS On univariate analysis, patients with lymphedema were more likely than controls to be overweight (body mass index >or= 25) (p = 0.009). They also were more likely to have had axillary radiation (p = 0.011), mastectomy (p = 0.008), chemotherapy (p = 0.033), more positive nodes (p = 0.009), fluid aspirations after surgery (p = 0.005), and active cancer status (p = 0.008). Strength training (p = 0.014) and air travel (p = 0.0005) were associated with less lymphedema occurrence. On multivariate analysis, the only factor significantly associated with lymphedema was being overweight (p = 0.022). CONCLUSIONS Being overweight is an important modifiable risk factor for lymphedema. Axillary radiation, more extensive surgery, chemotherapy, and active cancer status also were predictive of lymphedema. IMPLICATIONS FOR NURSING This study provides evidence that excess weight contributes to lymphedema; strength training and airline travel did not contribute to lymphedema.