Miracle-dz/UniFAR-FTUs huggingface dataset:
Stimulation of p-aminohippurate Transport by Slices of Rat Renal Cortex Following in Vivo Administration of Triiodothyronine∗

Summary Administration of T3 to weanling rats caused a marked increase in PAH transport in renal cortical slices but had no effect on NMN transport. When added directly to slices in vitro, T3 inhibited PAH transport. The results therefore indicate that T3 is transported as an organic acid and specifically stimulates the acid transport system, not by a generalized metabolic effect, but directly by substrate stimulation.
Autobiographical Memory in Depression: State or Trait Marker?

Two cognitive measures were used to assess 22 patients who met DSM–III–R criteria for major depressive disorder: the Autobiographical Memory (AM) test and the Dysfunctional Attitude Scale. They were followed up over seven months. Measurement of dysfunctional attitudes did not predict outcome at seven months. Overgeneral recall on the AM test at initial assessment, especially for emotionally positive memories, was highly correlated with failure to recover from depression and accounted for 33% of the variance in HRSD score at follow-up. Overgeneral recall of emotional memories did not change during follow-up. It is suggested that overgenerality is a trait marker indicating vulnerability to persistent depression.
A signal detection technique using LDPC decoder as channel decoder over recording channels

This paper introduces a signal detection technique using a low-density parity-check (LDPC) code over precoded partial response (PR) recording channels. Under a PR channel considered, the detection scheme can be realized through (1) the design of a precoder that a level detection is available and (2) the modification of the likelihood function (LF) for a sum-product algorithm. A LDPC decoder plays a role as a channel decoder and configures turbo-like systems with the concatenation of outer codes. Besides, the application of the scheme into conventional turbo-like system achieves the performance improvement irrespective of recording densities.
Recombinant antibodies for diagnostics and therapy against pathogens and toxins generated by phage display

Antibodies are valuable molecules for the diagnostic and treatment of diseases caused by pathogens and toxins. Traditionally, these antibodies are generated by hybridoma technology. An alternative to hybridoma technology is the use of antibody phage display to generate recombinant antibodies. This in vitro technology circumvents the limitations of the immune system and allows—in theory—the generation of antibodies against all conceivable molecules. Phage display technology enables obtaining human antibodies from naïve antibody gene libraries when either patients are not available or immunization is not ethically feasible. On the other hand, if patients or immunized/infected animals are available, it is common to construct immune phage display libraries to select in vivo affinity‐matured antibodies. Because the phage packaged DNA sequence encoding the antibodies is directly available, the antibodies can be smoothly engineered according to the requirements of the final application. In this review, an overview of phage display derived recombinant antibodies against bacterial, viral, and eukaryotic pathogens as well as toxins for diagnostics and therapy is given.
Isolation of a lentivirus from a macaque with lymphoma: comparison with HTLV-III/LAV and other lentiviruses

A retrovirus has been isolated on the human T-cell line HuT 78 after cocultivation of a lymph node from a pig-tailed macaque (Macaca nemestrina) that had died with malignant lymphoma in 1982 at the University of Washington primate center. This isolate, designated MnIV (WPRC-1) (M. nemestrina immunodeficiency virus, Washington Primate Research Center) shows the characteristic morphology of a lentivirus and replicates to high titers in various lymphocyte lines of human and primate origin. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of purified MnIV revealed multiple bands of structural proteins, including a major viral gag protein of 28 kilodaltons, that did not comigrate with the viral proteins of a human immunodeficiency virus (HIV [FRE-1]) that was also isolated on HuT 78 cells. The relatedness of MnIV to other lentiviruses (HTLV-III/LAV, EIAV, and visna) was examined in radioimmunoassays, by immunoblot techniques, and by N-terminal amino acid sequence analysis of the viral p28 gag protein. The immunoassays revealed cross-reactivity only between MnIV p28 and HTLV-III/LAV p24, and sequence analysis showed that 14 of the 24 N-terminal residues of MnIV p28 and HTLV-III/LAV p24 are identical. These results indicate that MnIV belongs to the same lentivirus family as HTLV-III/LAV but is only partially related to these human acquired immune deficiency syndrome retroviruses.
Effects of hyposmotic shock on taurine transport in isolated trout hepatocytes

Isolated trout hepatocytes exposed to hypotonic medium undergo a regulatory volume decrease (RVD) that occurs via two separate routes, K(+)‐Cl‐ cotransport and amino acid release, the ion efflux accounting for 70% of the total osmolyte loss. Taurine, glutamine and glutamic acid are the most important and represent 73% of the total amino acid content (53 mmol (l cell water)‐1). The osmolarity‐sensitive release of amino acids was studied using [3H]taurine. Kinetic studies indicated two components for taurine influx: a linear Na(+)‐independent transport and a saturable Na(+)‐dependent system with a Michaelis‐Menten constant (Km) of 122 microM and a maximum velocity (Vmax) of 31.2 pmol (mg protein)‐1 min‐1. This second way of uptake was also chloride dependent and indicated an apparent coupling ratio Na+:Cl‐:taurine of 2:1:1. The latter component and the taurine efflux were stimulated during RVD, leading to intracellular amino acid loss. Taurine efflux activation during volume recovery was transient and also dependent on the presence of both Na+ and Cl‐ in the extracellular medium. Furthermore, taurine release and RVD were slowed down when Ca2+ was omitted from the medium. These results suggested two distinct and complementary mechanisms for volume regulation in trout hepatocytes during hypotonic conditions.
Interference Analysis and Reduction for Wireless Systems

Throughout time, people have and will continue to use communications at an ever-increasing pace in an interference environment [1]. In addition to the widespread use of satellite systems during the decades of the 1970s and the 1980s, we are now living through the mobile revolution. A large percentage of the communications needs can be carried out satisfactorily, even in a bad interference situation, and people are willing to show moderation. For example, hearing a distant cochannel repeater when your local repeater is not active, while annoying, is not ‘‘unacceptable interference. ’’ Hearing adjacent channel splatter while carrying on a conversation on simplex or your local repeater, while affecting the quality of the conversation, is not truly unacceptable interference. If it makes communication completely impossible, then it should be considered interference, although it still may not necessarily be harmful or willful. Take note at this point that many of the noise sources to be defined here do not affect FM/PM type radio operation except to cause desensing of the radio, possibly masking the desired signal. This is the reason we strive to define and derive the qualitative measures by which we can design modern wireless system in an ever-increasing interference background. Up to this point, we have examined and analyzed distortion mainly in the form of fading that is caused to information signals by the wireless channel for the types of wireless systems currently being used. In this and the following chapters, we shall analyze and study interference and include
Monoclonal antibodies in cancer therapy.

Monoclonal antibody-based treatment of cancer has been established as one of the most successful therapeutic strategies for both hematologic malignancies and solid tumors in the last 20 years. The initial combining of serological techniques for cancer cell surface antigen discovery with hybridoma technology led to a series of landmark clinical trials that paved the way for new generation antibodies and subsequent clinical success. Optimization of anti-tumor immune responses through Fc modifications has also made a major contribution to clinical efficacy. The modulation of immune system interplay with tumor cells through targeting of T cell receptors has emerged as a powerful new therapeutic strategy for tumor therapy and to enhance cancer vaccine efficacy. This commentary will provide an overview of the history of antibody identification of tumor surface antigens, antigenic targets suitable for antibody-based therapy, antibody mechanisms of action, and recent successes of antibodies in the clinic.
The effect of early spine fixation on non-neurologic outcome.

INTRODUCTION It has been shown that spinal fracture fixation within 3 days can reduce the incidence of pneumonia, length of stay, number of ventilator days, and hospital charges. Our institutional protocol calls for surgical stabilization of spinal fractures within 3 days of admission. We hypothesized that compliance with an early spinal fracture fixation protocol (within 3 days of admission) would improve non-neurologic outcome in patients with spinal fractures. METHODS The trauma registry was queried for the period January 1988 through October 2001 to identify patients with spinal fractures requiring surgical stabilization. Patients were analyzed to determine the compliance with our protocol and to determine whether early spinal fixation can reduce the incidence of pneumonia, reduce length of stay, and reduce mortality. RESULTS 1,741 patients with spinal fractures were identified. 299 (17.2%) required surgical stabilization. 174 (58.2%) had surgical stabilization within 3 days while 125 (41.8%) had surgical stabilization greater than 3 days from admission. There were no significant differences between the two groups with regards to age (37.9 versus 42.5), admission GCS (14.1 versus 13.9), or ISS (22 versus 20.8). The incidence of pneumonia was similar in both groups (21.8 versus 25.6%). The mortality was higher in the early group as compared with the late group (6.9 versus 2.5%), although it did not reach statistical significance. The hospital length of stay was significantly shorter (14.3 versus 21.1) for patients who had early spine fixation, however there was no statistically significant difference between the two groups with regards to intensive care unit length of stay (7.2 versus 7.9) or number of ventilator days (5.02 versus 1.9). Patients who were severely injured (ISS > 25) also had a significantly shorter hospital length of stay (19.6 versus 29.1) if they underwent early spinal fixation. Patients with thoracic spine injury and associated spinal cord injury had a significantly shorter HLOS (10.1 versus 30.5), ICULOS (2.3 versus 13.1), and lower incidence of pneumonia (6.5 versus 33.3%). CONCLUSIONS Reasonable compliance with an early spinal fracture fixation protocol produced some outcome improvements in non-neurologic outcome. Early spine stabilization reduced hospital length of stay in all patients. Patients with thoracic spine trauma and a spinal cord injury had the greatest benefit in reduction of morbidity, HLOS and ICULOS from early stabilization. There was a trend toward poorer outcome in some groups with early spine stabilization. A rigid protocol requiring early surgical spine stabilization in all patients does not appear justified. Although early spine stabilization should be performed whenever possible to reduce hospital length of stay, the timing of this procedure should be individualized to allow patients with the most severe physiologic derangements to be optimized preoperatively.
Metric velocity and landmark distance estimation utilizing monocular camera images and IMU data

In this paper we present a novel approach for the estimation of metric velocities and metric distances to landmarks utilizing monocular images and inertial measurements only. The proposed algorithm is based on an Extended Kalman Filter and is closely related to the well known Simultaneous Localization and Mapping (SLAM). In contrast to standard SLAM formulations the state of an agent is expressed in the body frame instead of the inertial frame. This formulation results in direct observability of the velocity and landmark distances for dynamic trajectories and the ability to maintain a consistent estimate for non-dynamic trajectories.
Dual-band phase offset line with required transmission phases at two operational frequencies

The paper presents analytical design methodology for realizing dual-band phase offset line using multi-section coupled lines. The circuit is designed to emulate a transmission line of 50 Ω characteristic impedance with two different arbitrary phases at the two frequencies. A prototype has been design at 1960 /3500 MHz that is used in dual-band Doherty power amplifier operating for CDMA and WiMAX applications.
Efficacy of CC Traps and Seasonal Activity of Adult Bemisia argentifolii (Homoptera: Aleyrodidae) in Imperial and Palo Verde Valleys, California

Abstract Adult whitefly Bemisia argentifolii Bellows & Perring trap (CC trap) catches were compared with suction type trap catches. CC trap catches were significantly correlated to the suction trap catches. Higher numbers of B. argentifolii adults were caught in CC traps oriented toward an untreated, B. argentifolii-infested, cotton field as compared with traps oriented toward Bermuda grass fields, farm roads, or fallow areas. CC trap catches at five heights above ground (from 0 to 120 cm) were significantly related to each other in choice and no-choice studies. CC trap catches were low in the Imperial and Palo Verde Valleys from late October to early June each of 1996, 1997, and 1998. Trap catches increased with increasing seasonal air temperatures and host availability. Trap catches were adversely affected by wind and rain. Abrupt trap catch increases of 40- to 50-fold for 1–2 d in late June to early July followed by abrupt decreases in adult catches suggest migrating activity of adults from other nearby crop sources.
ARQUITECTURA DEL SISTEMA DE MONITOREO Y GENERACIÓN DE NOTIFICACIONES EN GNU/LINUX MEDIANTE AGENTES PARA UN SISTEMA DE GESTIÓN DIGITAL

Es prioritario mejorar el desempeno y la eficiencia de los procesos administrativos de las Instituciones de Educacion Superior (IES), para lo cual se requiere de Sistemas de Gestion Digital (SGD) que apoyen las funciones sustantivas de la IES y ofrezcan mecanismos para mantener la disponibilidad de los servicios. El objetivo fue disenar la Arquitectura del Sistema de Monitoreo y Generacion de Notificaciones (SMGN) basada en agentes. La funcion de los agentes fue el monitoreo de servidores y servicios en tiempo real, integrando el envio de notificaciones y generacion de estadisticas. La implementacion del SMGN se probo con los servidores donde se localizan los componentes del SGD, los resultados obtenidos son satisfactorios, se obtuvieron mejores tiempos de respuesta al atender las fallas antes de que el usuario se percate de que el servicio no esta activo. Por tanto, el SMGN se encarga de mejorar la eficiencia y disponibilidad de los servicios del SGD, mejorando la productividad, los tiempos de respuesta y la atencion para la comunidad universitaria, beneficiando hasta a 3960 usuarios de la IES con una inversion minima.
Camera calibration parameters for oriented person re-identification

Person re-identification is a challenging task when there exist strong appearance changes for different viewpoints of the person captured by a distributed camera network. To better solve this issue a multi-view oriented model of the person has been proposed. In this paper, we analyze the camera calibration parameters required to be used in the oriented people re-identification and propose a method to retrieve those values to be used in the capture of people perspectives with different known orientations respect to the camera. Usually, individual camera calibration parameters on a large distributed camera network are not available. A self-calibration method through the usage of short-term trackers of multiple persons is proposed. Only two extrinsic camera calibration parameters are required. Experimental results based on the processing of different public datasets demonstrate the effectiveness of our approach.
Direct conversion dual-band SiGe BiCMOS transmitter and receive PLL IC for CDMA/WCDMA/AMPS/GPS applications

A direct conversion 0.4/spl mu/m SiGe BiCMOS transmitter and receiver PLL consists of two transmitters, two PLLs, and an integrated VCO for cellular, PCS/IMT and GPS applications. The chip consumes 71mA at 2.7V with -55dBc ACPR at 885kHz offset and -134dBm/Hz noise at 45MHz offset for cellular, and 79mA, -56dBc ACPR at 1.25MHz offset, and -132dBm/Hz noise at 80MHz offset for PCS.
AUT-UTP: Urban traffic panel detection and recognition dataset

Recently, detection and recognition of traffic panels and their textual information is studied increasingly to become the next working part of driver assistance systems and autonomous cars. These information are especially useful when other facilities fail to provide enough information about routes and places, like when Global Positioning System (GPS) gets blocked in high density urban areas. However, previous researches in the field are only on road panels, which are in much more simpler conditions than the ones in high density urban areas. As there is no such dataset available to address this problem in real world application, like cluttered urban scenarios, this paper presents an extensive dataset of videos recorded on a moving vehicle from traffic panels in urban areas with ground truth data refined by human observation. This paper presents an analysis on quality and quantity of the data and provides a statistical report. Video sequences are categorized according to their different characteristics so that researchers can choose the part of data which benefits their research goals. Ground truth data and characteristics of each scenario are produced using semi-automatic methods, followed by more than 10000 times of manual refinement for bounding boxes around the panels, also for both English and Persian text inside them.
The structure of CC-1065, a potent antitumor agent and its binding to DNA

The crystal and molecular structure of a potent antitumor agent, CC1065 (C37H33N708), has been determined, and circular dichroism studies have demonstrated a strong interaction between CC-1065 and DNA. The triclinic unit cell, space group P1, of dimensions a = 11.063 (3) A, b = 13.311 (2) A, c = 13.405 (2) A, a = 85.18 (1)O, @ = 99.52 (l)', and y = 103.36 (2)O, contains two CC-1065 molecules and disordered solvent molecules (two methanols and three waters). Intensity data for 6284 reflections were collected at -155 (2) OC; the final R value was 0.08 for 241 1 significant high-angle reflections. NMR spectroscopy was very important in assigning kinds of atoms. The CC-1065 molecule consists of three substituted benzodipyrrole moieties linked by amide bonds. One terminal moiety has a cyclopropyl ring; the only asymmetric carbons in the molecule are at the cyclopropyl ring junctures. The two symmetry-independent molecules have the same configuration, but the absolute configuration is not known. The CC-1065 molecules are curved and somewhat twisted with the outer periphery hydrophilic and the inner surface lipophilic. The interaction between CC-1065 and a number of DNA polymers was studied by circular dichroism. The CD effect requires double-stranded DNA and is strongest with poly(dA-dT):poly(dA-dT). A number of antitumor agents a re known to bind to deoxyribonucleic acid by nonintercalative means. '-s Netropsin is an oligopeptide that binds preferentially to poly(dA):poly(dT) and is thought to interact through hydrogen bonds in the minor groove of DNA. 's2 Anthramycin is a pyrrolo[ 1,4] benzodiazepine that binds covalently to guanine in the minor g r o ~ v e . ~ , ~ Braithwaite and Baguley have investigated netropsin, distamycin, and several bisamidine and bisquaternary ammonium heterocyclic drugs by viscometric, spectrophotometric, and fluorometric methods, and propose that they all bind in the minor groove of the D N A double helix.5 A new antitumor agent, CC-1065, also binds to D N A without intercalation.6 CC-1065 is produced by a soil culture, streptomyces ~ e l e n s i s , ~ and was isolated in pure form8 and found to be significantly more cytotoxic in vitro than actinomycin, vinblastine, or maytansine? In vivo, CC-1065 is highly active against a variety of mouse tumors,* and, as a result, has been selected by the (1) (1) Berman, H. M. ; Neidle, S. ; Zimmer, C. ; Thrum, H. Biochim. (2) Wartell, R. M. ; Larson, J. E. ; and Wells, R. D. J . Bio! Chem. 1974, Biophys. Acta 1979, 561, 124-131.
Manifestations of West Nile neuroinvasive disease

Since its introduction to North America in 1999, West Nile virus, an arthropod‐borne flavivirus, has become the most significant cause of epidemic encephalitis in the western hemisphere. While most human infections with the virus are asymptomatic and the majority of symptomatic persons experience febrile illness, severe neurologic manifestations, including meningitis, encephalitis, and poliomyelitis may be seen. This review summarizes the virology, epidemiology and pathogenesis of human infection with West Nile virus, and details recent advances in our understanding of the pathophysiology and various clinical manifestations of infection. Published in 2006 by John Wiley & Sons, Ltd.
Proposal of a Six-Legged Mini-Shovel and Its Mechanism Design and Walking Analysis Based on Static Analysis and a Computer-Aided Design Dynamic Model

The conventional method of movement of a mini-shovel used for interior demolition work is a crawler. However, a crawler scratches road surfaces and floors; moreover, it lacks body stability when climbing up and down stairs. In this study, we propose a six-legged mini-shovel for interior demolition work and develop it based on a mini-shovel SK09SR, which is a product for the interior demolition work market. With regard to mechanism design, first the basic sizes of the chassis and leg are determined by the reachable region of the legs that is necessary for climbing stairs. Next, the leg mechanism is designed using static analysis based on the constraints of the maximum output of the hydraulic cylinder and pump. In addition, in order to demonstrate the dynamic analysis and simulation of walking, a three-dimensional computer-aided design dynamic model of six-legged mini-shovel is produced on the mechanism analysis software DADS. Then, the servo control of the hydraulic cylinder is designed. Finally, the results of dynamic analysis and simulation of walking, such as going straight, turning, side walk, diagonal walk, lifting vehicle height and climbing stairs, show that our proposed six-legged mini-shovel is a useful and effective method of movement for interior demolition work.
Integration of cloud based eCare services: a multidisciplinary challenge

Due to changes in the demographic situation of most Western European countries, interest in ICT supported care services grows fast. eCare services are believed to be cost-effective and could lead to an increased quality of life of both care receiver and (in)formal care giver. Currently adoption and integration of these services is slowed down by several barriers such as an unclear added value, a lack of regulations or a sustainable financial model. In order to understand the interactions between political, market related and technological forces, as sources of these barriers, collaboration between all actors involved in eCare service development (user and technological research groups, care organizations, technological partners, techno-economic research groups, etc.) is needed. In this paper various tools and methodologies, applied in the iMinds OCareClouds project, are discussed that foster collaboration and allow identification and understanding of the different forces.