Miracle-dz/UniFAR-FTUs huggingface dataset:
Dexmedetomidine Does Not Alter the Sweating Threshold, But Comparably and Linearly Decreases the Vasoconstriction and Shivering Thresholds

Background: Clonidine decreases the vasoconstriction and shivering thresholds. It thus seems likely that the alpha2 agonist dexmedetomidine will also impair control of body temperature. Accordingly, the authors evaluated the dose‐dependent effects of dexmedetomidine on the sweating, vasoconstriction, and shivering thresholds. They also measured the effects of dexmedetomidine on heart rate, blood pressures, and plasma catecholamine concentrations. Methods: Nine male volunteers participated in this randomized, double‐blind, cross‐over protocol. The study drug was administered by computer‐controlled infusion, targeting plasma dexmedetomidine concentrations of 0.0, 0.3, and 0.6 ng/ml. Each day, skin and core temperatures were increased to provoke sweating and then subsequently reduced to elicit vasoconstriction and shivering. Core‐temperature thresholds were computed using established linear cutaneous contributions to control of sweating, vasoconstriction, and shivering. The dose‐dependent effects of dexmedetomidine on thermoregulatory response thresholds were then determined using linear regression. Heart rate, arterial blood pressures, and plasma catecholamine concentrations were determined at baseline and at each threshold. Results: Neither dexmedetomidine concentration increased the sweating threshold from control values. In contrast, dexmedetomidine administration reduced the vasoconstriction threshold by 1.61 +/‐ 0.80 [degree sign] Celsius [center dot] ng sup ‐1 [center dot] ml (mean +/‐ SD) and the shivering threshold by 2.40 +/‐ 0.90 [degree sign] Celsius [center dot] ng sup ‐1 [center dot] ml. Hemodynamic responses and catecholamine concentrations were reduced from baseline values, but they did not differ at the two tested dexmedetomidine doses. Conclusions: Dexmedetomidine markedly increased the range of temperatures not triggering thermoregulatory defenses. The drug is thus likely to promote hypothermia in a typical hospital environment; it is also likely to prove an effective treatment for shivering.
Studies on rat thyroid after oral administration of mancozeb: Morphological and biochemical evaluations

Mancozeb, an ethylenebisdithiocarbamate (EBDC), has been studied for its effects on rat thyroid. Single oral administration of mancozeb at different concentrations (9600, 12 000, 15 000 and 18 750 mg kg−1 body wt) has derived the oral LD50 value as 15 000 mg kg−1 body wt. in male rats. Mancozeb at repeated oral doses of 500, 1000 and 1500 mg kg−1 day−1 for periods of 30, 90, 180 and 360 days has produced dose‐dependent signs of toxicity and death of animals. The fungicide caused a significant increase in thyroid/body weight ratio and histopathological changes. Reduced levels of thyroid radioiodine (125I) uptake, serum protein‐bound iodine (PB125I), thyroxine (T4) and reduced activity of thyroid peroxidase (TPO) have also been observed after exposure to mancozeb. Thus, mancozeb has been shown to produce marked structural and functional changes in thyroid of rats. © 1997 John Wiley & Sons, Ltd. © 1997 by John Wiley & Sons, Ltd.
Predicting Protein-Ligand Binding Affinities Using Novel Geometrical Descriptors and Machine-Learning Methods

Inspired by the concept of knowledge-based scoring functions, a new quantitative structure-activity relationship (QSAR) approach is introduced for scoring protein-ligand interactions. This approach considers that the strength of ligand binding is correlated with the nature of specific ligand/binding site atom pairs in a distance-dependent manner. In this technique, atom pair occurrence and distance-dependent atom pair features are used to generate an interaction score. Scoring and pattern recognition results obtained using Kernel PLS (partial least squares) modeling and a genetic algorithm-based feature selection method are discussed.
Dementia Population Risk Tool (DemPoRT): study protocol for a predictive algorithm assessing dementia risk in the community

Introduction The burden of disease from dementia is a growing global concern as incidence increases dramatically with age, and average life expectancy has been increasing around the world. Planning for an ageing population requires reliable projections of dementia prevalence; however, existing population projections are simple and have poor predictive accuracy. The Dementia Population Risk Tool (DemPoRT) will predict incidence of dementia in the population setting using multivariable modelling techniques and will be used to project dementia prevalence. Methods and analysis The derivation cohort will consist of elderly Ontario respondents of the Canadian Community Health Survey (CCHS) (2001, 2003, 2005 and 2007; 18 764 males and 25 288 females). Prespecified predictors include sociodemographic, general health, behavioural, functional and health condition variables. Incident dementia will be identified through individual linkage of survey respondents to population-level administrative healthcare databases (1797 and 3281 events, and 117 795 and 166 573 person-years of follow-up, for males and females, respectively, until 31 March 2014). Using time of first dementia capture as the primary outcome and death as a competing risk, sex-specific proportional hazards regression models will be estimated. The 2008/2009 CCHS survey will be used for validation (approximately 4600 males and 6300 females). Overall calibration and discrimination will be assessed as well as calibration within predefined subgroups of importance to clinicians and policy makers. Ethics and dissemination Research ethics approval has been granted by the Ottawa Health Science Network Research Ethics Board. DemPoRT results will be submitted for publication in peer-review journals and presented at scientific meetings. The algorithm will be assessable online for both population and individual uses. Trial registration number ClinicalTrials.gov NCT03155815, pre-results.
Prognosis of trochanteric pain in primary care.

BACKGROUND Trochanteric pain is the second most important diagnosis of hip problems presenting in primary care, but its incidence and prognosis in this context is largely unknown. AIM To determine the 1- and 5-year prognoses of trochanteric pain and the predictive variables for consistent complaints. DESIGN OF THE STUDY Retrospective cohort study. SETTING One hundred and sixty-four patients (mean age = 55 years, 80% female) with incidental trochanteric pain in the years 1996 or 2000 were asked in 2001 for past and present symptoms of trochanteric pain. Therapeutic interventions, demographic factors and comorbidity were also investigated. METHOD The databases of 39 GPs were screened in order to identify all incident cases with a suspicion of trochanteric pain in the years 1996 or 2000. These cases were sent a questionnaire. RESULTS The incidence of trochanteric pain in primary care is 1.8 patients per 1000 per year. After 1 year at least 36% still suffered from trochanteric pain, and after 5 years this was 29%. Patients with osteoarthritis (OA) in the lower limbs had a 4.8-fold risk of persistent symptoms after 1 year, as compared to patients without OA. Patients who had received a corticosteroid injection had a 2.7-fold chance of recovery after 5 years, as compared with patients who had not received an injection. CONCLUSION Trochanteric pain is shown to be a chronic disease in a substantial number of patients. The disorder is associated with much impairment when conducting daily activities.
One Size does not Fit All: Information Security and Information Privacy for genomic Cloud Services

Most extant genomic cloud services strive to maximize information security and information privacy protection thereby neglecting the diversity of information practices in genomic research. Such a one-size-fits-all approach is not expedient and decreases the overall system usability and performance. While there is growing awareness that employed information security and information privacy measures must adapt to information security and information privacy requirements inherent to information practices, limited design knowledge exists on how to actually design genomic cloud services capable to account for differences in information practices in genomic research. In this research-in-progress, we propose a model for genomic cloud services that dynamically adapt to the diverse information security and information privacy requirements in genomic research. Our research contributes to the scientific knowledge base by capturing design knowledge for secure, privacy-preserving, and usable genomic cloud services, accounting for conflicts between information security and information privacy, and fostering understanding of information privacy as a context-sensitive construct.
Primary chondro‐osseous melanoma (chondrosarcomatous and osteosarcomatous melanoma)

Melanoma can rarely show malignant chondro‐osseous differentiation and can cause diagnostic confusion. We report 3 cases of primary melanoma with extensive bone and cartilage matrix. The first case arose in the nasal mucosa of a 72‐year‐old woman, the second case in the left index finger of a 26‐year‐old woman and the third case in the left cheek of a 68‐year‐old woman. In tumors where osseous and chondroid differentiation appear in mucosa and skin, primary melanoma with chondro‐osteosarcomatous differentiation should be considered in the differential. Careful histological examination together with clinical correlation and ancillary immunohistochemical studies can ensure the correct diagnosis is made.
ADMA, SDMA and L-arginine may be Novel Targets in Pharmacotherapy for Complications due to Cardiopulmonary Bypass

Summary Background: In this study, the effects of olmesartan therapy on asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), L-arginine and inducible nitric oxide synthase (iNOS) levels were investigated in patients undergoing cardiopulmonary bypass. Methods: Patients were randomly allocated to two groups, control and olmesartan. Olmesartan was administered 30 mg once a day beginning from preoperative day 5 to postoperative day 28 and on operation day. Blood was drawn from all patients and ADMA, SDMA, L-arginine and iNOS levels were analyzed at six time points (T1: before anesthesia induction, T2: during cardiopulmonary bypass, T3: five min after the cross-clamp was removed, T4: after protamine infusion, T5: on postoperative day 3 and T6: on postoperative day 28). Results: In the olmesartan treated group, iNOS levels exhibited significant decreases at T2, T3, T4, T5 and T6 time points compared with control group (p<0.001, p<0.05, p<0.001, p<0.01, p<0.05 respectively). ADMA levels were significantly lower in olmesartan treated group than in control group at T3, T4, T5 and T6 time points (p<0.05, p<0.05, p<0.05, p<0.01 respectively). SDMA levels at T2, T3 and T6 time points were higher in control group than olmesartan group. L-Arginine levels were significantly higher at T2 and T3 time points in olmesartan treated group than control group (p<0.001, p<0.01). Conclusions: It was concluded that administration of olmesartan reduced plasma ADMA, SDMA, iNOS levels and enhanced L-arginine level in CPB time and it could reduce potential postoperative complications through reducing oxidative stress and inflammatory response in the postoperative period after coronary bypass surgery.
Overlapping Genes Produce Proteins with Unusual Sequence Properties and Offer Insight into De Novo Protein Creation

ABSTRACT It is widely assumed that new proteins are created by duplication, fusion, or fission of existing coding sequences. Another mechanism of protein birth is provided by overlapping genes. They are created de novo by mutations within a coding sequence that lead to the expression of a novel protein in another reading frame, a process called “overprinting. ” To investigate this mechanism, we have analyzed the sequences of the protein products of manually curated overlapping genes from 43 genera of unspliced RNA viruses infecting eukaryotes. Overlapping proteins have a sequence composition globally biased toward disorder-promoting amino acids and are predicted to contain significantly more structural disorder than nonoverlapping proteins. By analyzing the phylogenetic distribution of overlapping proteins, we were able to confirm that 17 of these had been created de novo and to study them individually. Most proteins created de novo are orphans (i.e., restricted to one species or genus). Almost all are accessory proteins that play a role in viral pathogenicity or spread, rather than proteins central to viral replication or structure. Most proteins created de novo are predicted to be fully disordered and have a highly unusual sequence composition. This suggests that some viral overlapping reading frames encoding hypothetical proteins with highly biased composition, often discarded as noncoding, might in fact encode proteins. Some proteins created de novo are predicted to be ordered, however, and whenever a three-dimensional structure of such a protein has been solved, it corresponds to a fold previously unobserved, suggesting that the study of these proteins could enhance our knowledge of protein space.
A Model of Lipid A Biosynthesis in E . coli

lipopolysaccharide, itself a major component of the Gramnegative bacterial outer membrane. We modeled the nine enzyme-catalyzed steps its biosynthesis in E. coli, focusing particularly on biosynthesis regulation, which occurs through regulated degradation of the LpxC and WaaA enzymes. The model agrees with many experimental findings, including the lipid A production rate and the behaviors of several LpxA mutants. Flux control is dominated by LpxC if pathway regulation is ignored, but by LpxK if regulation is present. These results suggest that LpxK may be a useful drug target.
Evaluation of GaN HEMTs for high-voltage stage of isolated DC-DC converters

This paper presents an experimental study of the half-bridge based on high voltage enhancement mode GaN high electron mobility transistors (HEMTs). It was tested with pure inductive load at various switching frequencies and power levels to verify gate driver and cooling system. All tests performed confirm excellent performance of the 650 V GaN HEMTs and the developed half-bridge stage may be applied in future design of the fully controlled DC-DC converter for PV applications.
Peopleware: key to success of information systems

The theme of this symposium, "The Systems Approach: Key to Successful Computer Applications", attracted a significant response on the part of computer professionals, managers, and users. Twenty-four papers were selected from over 100 competing in traditional technical areas of hardware, software, simulation, information retrieval, and programming techniques. Increasing numbers of papers were submitted in areas recognized as keys to systems success including <u>user involvement</u>, modelling, novel and useful applications, data bases, security, management, communications and networks, social implications, and <u>peopleware</u>.
Community Archives: The Shaping of Memory

Introduction to the series - Geoffrey Yeo Introduction: Communities and archives - a symbiotic relationship - Jeannette A. Bastian and Ben Alexander PART 1: A COMMUNITY ARCHIVES MODEL 1. 'It is noh mistri, wi mekin histri. ' Telling our own story: independent and community archives in the UK, challenging and subverting the mainstream - Andrew Flinn and Mary Stevens 2. Special, local and about us: the development of community archives in Britain - David Mander PART 2: COMMUNITIES AND NON-TRADITIONAL RECORD KEEPING 3. The Single Noongar Claim: native title, archival records and aboriginal community in Western Australia - Glen Kelly 4. Oral tradition in living cultures: the role of archives in the preservation of memory - Patricia Galloway 5. We are our memories: community and records in Fiji - Setareki Tale and Opeta Alefaio PART 3: RECORDS LOSS, DESTRUCTION AND RECOVERY 6. Archiving the queer and queering the archives: a case study of the Canadian Lesbian and Gay Archives (CLGA) - Marcel Barriault 7. A living archive, shared by communities of records - Eric Ketelaar 8. Truth commissions and the construction of collective memory: the Chile experience - Joel A. Blanco-Rivera PART 4: ONLINE COMMUNITIES: HOW TECHOLOGY BRINGS COMMUNITIES AND THEIR RECORDS TOGETHER 9. From Yizkor Books to weblogs: genocide, grassroots documentation and new technologies - Andras Riedlmayer and Stephen Naron 10. Co-creation of the Grateful Dead sound archive: control, access and curation communities - David A. Wallace PART 5: BUILDING A COMMUNITY ARCHIVE 11. 'All the things we cannot articulate': colonial leprosy archives and community commemoration - Ricardo L. Punzalan 12. Overcoming anonymity: Kittitians and their archives - Victoria Borg O'Flaherty 13. Always queer, always here: creating the Black Gay and Lesbian Archive in the Schomburg Center for Research in Black Culture - Steven G. Fullwood Conclusion: The archivist and community - Richard J. Cox.
Multimodalité de la communication langagière humaine : interaction geste/parole et encodage de distance dans le pointage

Designer un objet a l’attention d’un interlocuteur est l’un des processus fondamentaux de la communication langagiere. Ce processus est generalement realise a travers l’usage combine de productions vocales et manuelles. Le but de ce travail est de comprendre et de caracteriser les interactions entre la parole et le geste manuel dans des tâches de deixis spatiale, afin de determinerde quelle facon l’information communicative est portee par chacun de ces deux systemes,et de tester les principaux modeles de traitement du geste et de la parole.La premiere partie de l’etude concerne la production du pointage vocal et manuel. L’originalite de ce travail consiste a rechercher des parametres d’encodage de la distance dans les proprietes acoustiques, articulatoires et cinematiques du pointage multimodal, et a montrer que ces differentes caracteristiques sont correlees les unes aux autres, et sous-tendues par un meme comportement moteur de base : designer un objet distant implique de produire des gestes plus larges, qu’ils soient vocaux ou manuels. Ce patron moteur peut alors etre rapporte a l’encodage phonologique de la distance dans les langues du monde. Le paradigme experimental utilise dans cette etude contraste des pointages bimodaux vs unimodaux vocaux vs unimodaux manuels, et la comparaison de ces differentes conditions revele par ailleurs une cooperation bi directionnelle entre les modalites vocales et manuelles, qui se repartissent la charge informative lorsqu’elles sont utilisees ensemble.La deuxieme partie de l’etude explore le developpement du pointage multimodal. Les proprietes du pointage multimodal sont analysees chez des enfants de 6 a 12 ans, dans une tâche experimentale comparable a celle des adultes. Cette deuxieme experience atteste d’un developpement progressif du couplage geste/parole pour la deixis spatiale. Elle revele que la distance est encodee preferentiellement dans les gestes manuels des enfants, par rapport a leurs gestes vocaux(surtout chez les jeunes enfants). Elle montre egalement que l’usage cooperatif des gestes manuels et de la parole est deja a l’oeuvre chez les enfants, avec cependant plus d’influence du geste sur la parole que le patron inverse.Le troisieme volet de ce travail considere les interactions sensorimotrices dans la perception de la deixis spatiale. Une etude experimentale basee sur un principe d’amorcage intermodal montre que le geste manuel joue un role dans le mecanisme de perception/production des unites semantiques du langage. Ces donnees sont mises en parallele avec les etudes sur la naturesensorimotrice des representations dans le traitement des unites sonores du langage.L’ensemble de ces resultats plaide pour une representation fortement integree des gestes manuels et de la parole dans le cerveau langagier humain, et ce meme a un stade relativement precoce du developpement. Ils montrent egalement que l’encodage de la distance est un indice robuste,present dans tous les aspects du pointage multimodal.
Introducción al Bronce final en el noroeste de la provincia de Huelva

Pretendemos con este trabajo llenar un vacio dentro de la arqueologia de la Sierra de Huelva; aun en escaso numero, se conocen ya algunos yacimientos calcoliticos y del Bronce Pleno en esta zona, pero hasta ahora desconociamos el comportamiento que ofrecia en el Bronce Final. Por ello resumimos los resultados de la prospeccion realizada por nosotros de los rios Chanza y Murtigas dentro de los terminos municipales de Aroche y Encinasola: la cuenca del rio Guadiana en el noroeste de la provincia de Huel va'. Aunque la prospeccion abarco desde la Prehistoria al Medievo, tratamos los datos obtenidos para el Bronce Final por razon a la importancia que deben tener. A ella se han sumado mas labores de campo que han permitido completar el panorama trazado anteriormente 2. Si existe un elemento que defina el noroeste de la provincia de Huelva, este es su red fluvial, volcada al. rio Guadiana. Recoge aguas este rio en dos afluentes, el Chanza y el Murtigas. En orden a su orografia se le suele denominar los Picos de Aroche, titulo que obedece mas a la contraposicion con la Sierra de Aracena que
Increased expression of stanniocalcin 2 is associated with tumor progression after radiotherapy in patients with cervical carcinoma.

AIM This study aimed to analyze the expression, clinical significance of stanniocalcin 2 in cervical carcinoma patients who were treated with radiotherapy. METHODS Stanniocalcin 2 expression was determined by real-time PCR in 10 pairs of cervical cancer and adjacent normal cervical tissues. Tumor samples from 92 patients diagnosed from 2004 to 2007 were studied. All samples were obtained prior to treatment start. All cases were clinically diagnosed and pathologically confirmed to be cervical carcinoma without distant metastasis, and have been treated with radical radiation therapy and followed-up for five years. The samples were immunohistochemically analyzed for stanniocalcin 2 expression and survival analyses were performed. RESULTS The tumors of cervical cancer patients had significantly increased expression of stanniocalcin 2 at mRNA level compared with adjacent normal cervical tissues. High levels of stanniocalcin 2 expression was correlated with shorter overall survival, whereas low levels of stanniocalcin 2 expression was correlated with longer overall survival (P = 0.003) and progression free survival (P = 0.001) after radiotherapy. Moreover, high expression of stanniocalcin 2 was correlated with lymph node metastasis (P = 0.002). CONCLUSION Stanniocalcin 2 could be a useful marker for the prognosis of cervical cancer patients receiving radiotherapy. Stanniocalcin 2 may contribute to tumor development and radioresistance in cervical cancer.