Miracle-dz/UniFAR-FTUs huggingface dataset:
High-resolution SPECT study of regional cerebral blood flow in drug-free and drug-naive schizophrenic patients.

OBJECTIVE The purpose of the study was to compare regional cerebral blood flow (CBF) in schizophrenic patients never treated with psychotropic drugs (drug-naive) and in schizophrenic patients free from drugs for various amounts of time. METHOD Seventeen schizophrenic patients (nine who were drug naive and eight who had been drug free for at least 3 weeks) and 12 healthy volunteers were included in the study. Regional cerebral perfusion was studied with the use of a head-dedicated, high-resolution single photon emission computed tomography (SPECT) system. Cerebral SPECT scans were performed with technetium-99m-hexamethyl-propyleneamine oxime as a tracer. Regional CBF was measured as a ratio of regional tracer uptake to either cerebellar or whole brain tracer uptake. RESULTS When the cerebellum was taken as the reference region, the drug-naive patients showed a significant bilateral reduction of perfusion in the mesial, dorsolateral, and basal prefrontal cortex, in the temporal cortex, and in the subcortical gray structures: thalamus, caudate nucleus, and putamen/pallidum complex. No significant differences emerged in the comparison between the drug-free patients and the healthy subjects. With correction for whole brain activity, some of the differences that had been found disappeared, but a significant hypoperfusion persisted in the basal ganglia and thalamus of the drug-naive, but not the drug-free, patients. Few correlations between symptom presentation and regional CBF perfusion were observed in the schizophrenic patients. CONCLUSIONS These results suggest a pattern of cerebral hypoperfusion in schizophrenic patients never treated with neuroleptics that was not detectable in patients who had undergone various periods of pharmacological washout.
Immunogold and fluorescein immunolabelling of Legionella pneumophila within an aquatic biofilm visualized by using episcopic differential interference contrast microscopy

Biofilms containing diverse microflora were developed in tap water on glass and polybutylene surfaces. Legionella pneumophila within the biofilms was labelled with monoclonal antibodies and visualized with immunogold or fluorescein isothiocyanate conjugates. Development of a differential interference contrast technique in an episcopic mode enabled simultaneous visualization of the total biofilm flora and gold-labelled legionellae. The legionellae occurred in microcolonies within the biofilm in the absence of amoebae, suggesting that the bacterial consortium was supplying sufficient nutrients to enable legionellae to grow extracellularly within the biofilm.
Treatment Options for Clinically Recognized Disseminated Intravascular Coagulation

Current concepts of etiology and pathophysiology resulting in disseminated intravascular coagulation (DIC) form the basis of treatment of this hemostatic disorder. Due to the heterogeneous triggering diseases and different kinds of DIC, clinical symptoms such as predominant bleeding, thromboembolic complications or organ failure, clinical experience together with the profile of laboratory test results and their development over time provide the basis for the individually tailored treatment strategy. The guiding principle of therapy is to identify and vigorously treat the underlying cause of DIC without delay. Treatment options to correct the hemostatic defect and to dampen the intravascular clotting/fibrinolytic process include transfusion of blood products, heparin, antithrombin III, and antifibrinolytic agents. The availability of new drugs such as activated protein C, tissue factor pathway inhibitor, hirudin, or synthetic serine protease inhibitors, and the upcoming trials investigating the role of these and older treatment options will help us to more clearly recommend therapy in DIC of different etiology.
Molecular interactions between the components of the En‐I transposable element system of Zea mays

The sequence of the Inhibitor element Spm‐I8 isolated from the wx‐m8 allele has been determined. The element is 2242 bp in length. Its ends can be folded into long stem and loop structures. In a line containing the autonomous En element (wx‐m8+En) we have detected a 2.5‐kb transcript hybridizing to Spm‐I8. A cDNA copy of this En‐specific transcript containing 1.2 kb of the 3′ end was cloned and its DNA sequence was determined. The 3′ half of the cDNA is homologous to Spm‐I8 and the region of homology is interrupted by intervening sequences. In the absence of an autonomous En element two chimeric transcripts are observed in the wx‐m8 line which are probably initiated at the wx promoter and terminate in the Spm‐I8 insertion. In the presence of the En element, these transcripts are suppressed, possibly by a trans‐acting function of En, inhibiting transcription read‐through into Spm‐I8.
Heat stress causes inhibition of the de novo synthesis of antenna proteins and photobleaching in cultured Symbiodinium

Coral bleaching, caused by heat stress, is accompanied by the light-induced loss of photosynthetic pigments in in situ symbiotic dinoflagellate algae (Symbiodinium spp.). However, the molecular mechanisms responsible for pigment loss are poorly understood. Here, we show that moderate heat stress causes photobleaching through inhibition of the de novo synthesis of intrinsic light-harvesting antennae [chlorophyll a–chlorophyll c2–peridinin–protein complexes (acpPC)] in cultured Symbiodinium algae and that two Clade A Symbiodinium species showing different thermal sensitivities of photobleaching also show differential sensitivity of this key protein synthesis process. Photoinhibition of photosystem II (PSII) and subsequent photobleaching were observed at temperatures of >31°C in cultured Symbiodinium CS-73 cells grown at 25–34°C, but not in cultures of the more thermally tolerant control Symbiodinium species OTcH-1. We found that bleaching in CS-73 is associated with loss of acpPC, which is a major antennae protein in Symbiodinium. In addition, the thermally induced loss of this protein is light-dependent, but does not coincide directly with PSII photoinhibition and is not caused by stimulated degradation of acpPC. In cells treated at 34°C over 24 h, the steady-state acpPC mRNA pool was modestly reduced, by ≈30%, whereas the corresponding synthesis rate of acpPC was diminished by >80%. Our results suggest that photobleaching in Symbiodinium is consequentially linked to the relative susceptibility of PSII to photoinhibition during thermal stress and occurs, at least partially, because of the loss of acpPC via undefined mechanism(s) that hamper the de novo synthesis of acpPC primarily at the translational processing step.
Degenerative collagenous plaques of the hands.

This report describes the clinical and pathologic features of a series of patients we have observed with linear, firm plaques of the medial and lateral aspects of the hands. Five illustrative cases are presented. The lesions are bilateral and symmetrical and are situated at the juncture of the palmar and dorsal skin. Histologically, the process is characterized by a rather distinctive deposition of dense collagen and elastic tissue, involving most of the reticular dermis but usually sparing the papillary dermis and subcutis. The condition is chronic, essentially asymptomatic, and slowly progressive. Our patients could not date the exact onset of their lesions but had noticed slow development over a 5- to 15-year period. The only symptom mentioned by any of the patients has been stiffness resulting from advanced involvement of the flexor creases. In the fully developed case, both hands are symmetrically involved. A firm plaque extends from near the
Topological ordering of a list of randomly-numbered elements of a network

A network of directed line segments free of circular elements is assumed. The lines are identified by their terminal nodes and the nodes are assumed to be numbered by a non-topological system. Given a list of these lines in numeric order, a simple technique can be used to create at high speed a list in topological order.
Pengaruh Audit Manajemen, Komitmen Organisasional Manajer, dan Pengendalian Internal terhadap Penerapan Prinsip-Prinsip Good Corporate Governance

This study aims to examine the effect of Management Audit, Organizational Commitment Manager, Internal Control Against Application of Principles of Good Corporate Governance. The sample of this study is 62 manufacturing companies listed in Indonesia Stock Exchange (BEI) in 2013 with purposive sampling technique. The data was analized with logistic regression. The result showed that management audit has no effect on the implementation of good corporate governance principles, organizational commitment of managers has an effect on the application of the principle of good corporate governance, and internal control does not affect the implementation of good corporate governance principles. Ke yword: Management Audit, Organizational Commitment Manager, Internal Control, Principles of Good Corporate Governance.
Evidence for Alteration of EZH2, BMI1, and KDM6A and Epigenetic Reprogramming in Human Papillomavirus Type 16 E6/E7-Expressing Keratinocytes

ABSTRACT A number of epigenetic alterations occur in both the virus and host cellular genomes during human papillomavirus (HPV)-associated carcinogenesis, and investigations of such alterations, including changes in chromatin proteins and histone modifications, have the potential to lead to therapeutic epigenetic reversion. We report here that transformed HPV16 E6/E7-expressing primary human foreskin keratinocytes (HFKs) (E6/E7 cells) demonstrate increased expression of the PRC2 methyltransferase EZH2 at both the mRNA and protein levels but do not exhibit the expected increase in trimethylated H3K27 (H3K27me3) compared to normal keratinocytes. In contrast, these cells show a reduction in global H3K27me3 levels in vitro, as well as upregulation of the KDM6A demethylase. We further show for the first time that transformation with the HPV16 E6 and E7 oncogenes also results in an increase in phosphorylated EZH2 serine 21 (P-EZH2-Ser21), mediated by active Akt, and in a downregulation of the PRC1 protein BMI1 in these cells. High-grade squamous cervical intraepithelial lesions also showed a loss of H3K27me3 in the presence of increased expression of EZH2. Correlating with the loss of H3K27me3, E6/E7 cells exhibited derepression of specific EZH2-, KMD6A-, and BMI1-targeted HOX genes. These results suggest that the observed reduction in H3K27me3 may be due to a combination of reduced activities/levels of specific polycomb proteins and increases in demethylases. The dysregulation of multiple chromatin proteins resulting in the loss of global H3K27me3 and the transcriptional reprogramming in HPV16 E6/E7-infected cells could provide an epigenetic signature associated with risk and/or progression of HPV16-associated cancers, as well as the potential for epigenetic reversion in the future.
Expression of the stem cell markers CD133 and nestin in pancreatic ductal adenocarcinoma and clinical relevance.

BACKGROUND To evaluate the prognostic implication of cancer stem cell markers in pancreac ductal adenocarcinoma (PDAC), the expression of CD133 and nestin were investigated in a series of PDAC patients in relation to the survival rate. METHODS This series included 42 cases of PDAC patients and evaluated the stem cell markers CD133 and nestin expression detected by immunohistochemistry. The presence of immunopositive tumor cells considering intensity and area was evaluated and interpreted in comparison to the patients' clinicopathological and survival data. RESULTS Twenty eight cases (66.7%) showed high CD133 expression. The CD133 expression was mainly identified in the apical border of the tumor cell, but aberrant expression in the cytoplasmic or perinuclear location was also noted. High nestin expression in tumor cells were found in only 2 cases, but high nestin expression along perinuerial or stromal region was found in 15 cases (35.7%). There was no correlation between CD133, nestin expression and gemcitabine resistance. Statistically significant difference was found in patient survival in N stage (p=0.007), and CD133 expression (p= 0.014) in univariate analysis. Nestin expression wan not statistically significant, but it was helpful to identify the perineurial invasion. In Cox-regression hazard model stratified by age and sex for multivariable analysis, AJCC stage and CD133 were independent prognostic factors for overall survival. CONCLUSIONS CD133 expression is upregulated in PDAC that is related to poor prognosis, and treatment targeted the CD133 positive cancer/cancer stem cells might be a promising therapeutic strategy for this patients.
Estudio y modelado de la fiabilidad y estrés térmicos en transistores GaN para aplicaciones de microondas

En este trabajo se analizan los fenomenos de degradacion presentes en GaN HEMT, bajo condiciones de fuerte campo electrico; se presentan modelos de degradacion. Se presenta la caracterizacion de los efectos trampa en modo pulsado para estudiar la influencia del envejecimiento sobre estos efectos de degradacion. Se presenta un estudio de la influencia de la temperatura ambiente sobre los efectos debido a la presencia de estados trampa. Se ha apreciado la presencia del efecto kink en los dos transistores estudiados. En altas temperaturas (70°C), este efecto muestra menor influencia, y mas especialmente en los dispositivos envejecidos, en los que la presencia de estados trampa disminuye con el aumento de temperatura. Como base el modelo de degradacion de la corriente de saturacion, Idss, de Chou se propone un modelo de degradacion de la corriente de saturacion Idss para los dispositivos estudiados. Se propone un modelo para simular la degradacion de la corriente de fugas.
Structural visualization of the p53/RNA polymerase II assembly

Singh et al. dissected the human p53/Pol II interaction via single-particle cryo-electron microscopy, structural docking, and biochemical analyses. These findings indicate that p53 may structurally regulate DNA-binding functions of Pol II via the clamp domain, thereby providing insights into p53-regulated Pol II transcription.
Beam-Space MIMO simulations in a 3-D suburban environment

This work presents the capacity achieved in a 3-D simulation of BS-MIMO versus conventional MIMO and SISO. An ESPAR antenna was used as the directional antenna in the BS-MIMO configuration for both the transmitter and the receiver. The MIMO and SISO configuration used dipole antennas. The channel of each configuration was calculated in a 3-D model of Rosslyn, VA. The channel results were then used to calculate capacity for BS-MIMO, MIMO, and SISO. The results show BS-MIMO can achieve comparable capacity to MIMO; meaning that one steerable antenna can achieve the high data rates attributed to the larger, more complex, MIMO systems.
On the H-Manipulability of Fuzzy Social Choice Functions

In voting theory the well-known Gibbard-Satterthwaite theorem is about the manipulability of aggregators which consists of the aggregation of individual preferences expressed as a complete ordering over the set of alternatives. This paper deals with the generalization of such a theorem in a context where each individual expresses a fuzzy preference (weak) ordering. This extension is called H-manipulability. The concept of fuzzy game form as the generalization of Gibbard’s concept game form is also introduced here in a fuzzy framework. The proof of the Hmanipulability theorem is relied on the connection of fuzzy social choice functions with fuzzy aggregation rules. In particular, the dictatorship of fuzzy aggregation rules corresponds to the H-dictatorship fuzzy social choice.
Research on Power Incentives of the Compensation of Chinese Bank Executives and Risk Consequences

In recent years, the sky-high compensation of executives in financial industry has aroused heated discussion from the public and scholars at home and abroad has begun to test the reasonability of compensation design of bank executives. Considering the universal skepticism for bank executive compensation, this paper focuses on the reasons for the formation of sky-high compensation of bank executives and compensation gap between executives and employees, as well as their influences on bank risks. Specifically speaking, this paper firstly studies the influence of managerial power on executive compensation in banking. Then it explores the moderating effect of corporate governance on the relationship between managerial power and executive compensation. Finally, it studies the influences of bank executive compensation and compensation gap between executives and employees on bank risks. It concludes that, there is a positive relationship between managerial power and executive compensation in Chinese listed banks, corporate governance of the banks will negatively moderate the positive correlation between managerial power and executive compensation, and compensation gap in internal banks can induce bank risks. These conclusions suggest that the banks should moderately restrain the managerial power and make efforts to improve corporate governance level of banks to ensure the reasonability of executive compensation design, and should reduce the compensation gap reasonably between executives and employees to prevent bank risks caused by the abnormal compensation gap.
Comparison of the anaphylactoid response induced in rats by castanospermine and dextran.

The plant alkaloid castanospermine (10 mg/kg or higher, i.p.; 400 mg/kg, p.o.) induced in some rat strains an anaphylactoid reaction similar to that induced by dextran, i.e. erythema and edema of the snout, ears and paws, for several hours after administration. 86% of the rats from a responsive strain responded to castanospermine while 79% responded to dextran. Rats which responded to castanospermine showed marked, but transient, tachyphylaxis to a second dose of castanospermine or dextran. Rats maintained on a complex-carbohydrate-free diet also responded to castanospermine, excluding the possibility that the effect was due to absorption of dextran-like, dietary, complex carbohydrates. These data raise the possibility that some apparent food allergies in man could be due to the presence in the diet of plant alkaloids with properties similar to those of castanospermine.
Modélisation des conditions d'alimentation dans les contacts élastohydrodynamiques ponctuels

En lubrification, de nombreux mecanismes sont amenes a operer dans des conditions de sous-alimentation en lubrifiant, ce qui engendre une reduction globale ou locale des epaisseurs de film. Un modele est developpe afin d'etudier l'influence des conditions d'alimentation sur le comportement du contact elastohydrodynamique ponctuel. Pour approcher la realite physique, le modele considere des debits locaux d’alimentation generes par la distribution du lubrifiant adherant aux surfaces a l'entree du contact et vehiculees par elles. Le probleme est alors resolu sur deux zones complementaires a l'aide d'une equation de Reynolds modifiee : une zone de film complet et une zone de film partiel. La position de la frontiere libre en formation et en rupture de film, resulte de la conservation de la masse entre ces deux zones. La solution numerique est obtenue a l'aide des techniques multigrilles. Lorsque le contact est alimente avec des epaisseurs de lubrifiant uniformes, les resultats montrent que la reduction de l'epaisseur centrale de film peut etre generalisee a l'aide d'une relation simple incorporant deux comportements asymptotiques physiques. Un seul parametre varie suivant les conditions de fonctionnement du contact. Ce parametre permet egalement, en premiere approximation, d'evaluer la reduction progressive des epaisseurs de film en fonction d'un nombre de passages successifs, lorsque les effets de realimentation sont negligeables. Le contact est ensuite etudie avec une distribution variable du lubrifiant sur les surfaces. Les resultats montrent que cette distribution est directement responsable de la variation des epaisseurs de film a l'interieur du contact. Une partie du contact peut etre tres severement sous-alimentee alors qu'une autre peut etre suralimentee. Une bonne correlation, a la fois qualitative et quantitative, est obtenue avec les resultats experimentaux.
Chronic Pancreatitis : Newer Concepts 523 chronic pancreatitis

Pramod Kumar Garg, New Delhi Chronic pancreatitis (CP) is a chronic progressive inflammatory disease of the pancreas. the predominant cause of CP is considered to be alcohol abuse in countries such as Usa, UK, Germany, Brazil, and Japan while it is idiopathic in countries such as india and China. idiopathic CP that is prevalent in india is also known as tropical calcific pancreatitis (tCP). the term, tCP, is used to refer to a special type of CP with large pancreatic calculi that affects very young malnourished individuals who often develop diabetes and have an aggressive course of the disease. initially described from indonesia, it has been reported from many other tropical countries including india, nigeria, Uganda, west indies, Kenya, sri Lanka, Medgasker and Zaire. the largest series has however, been described from south india by Geeverghese. subsequently, there have been many reports of its occurrence in other parts of india (particularly Karnataka, tamil nadu, orissa, Maharashtra and Delhi). however, recent observations, both clinical and genetic, have cast doubt about the terminology and description of tCP as discussed subsequently.
Astaxanthin as a Potential Neuroprotective Agent for Neurological Diseases

Neurological diseases, which consist of acute injuries and chronic neurodegeneration, are the leading causes of human death and disability. However, the pathophysiology of these diseases have not been fully elucidated, and effective treatments are still lacking. Astaxanthin, a member of the xanthophyll group, is a red-orange carotenoid with unique cell membrane actions and diverse biological activities. More importantly, there is evidence demonstrating that astaxanthin confers neuroprotective effects in experimental models of acute injuries, chronic neurodegenerative disorders, and neurological diseases. The beneficial effects of astaxanthin are linked to its oxidative, anti-inflammatory, and anti-apoptotic characteristics. In this review, we will focus on the neuroprotective properties of astaxanthin and explore the underlying mechanisms in the setting of neurological diseases.
The inherent tensions and ambiguities of hope: Towards a post-formal analysis of experiences of advanced-cancer patients

Sociological and anthropological analyses of hope in health-care contexts have tended to address institutional processes, especially the power dynamics that function through such systems or political economies of hope, which in turn shape interactions through which hopes are managed. This article extends this approach through a more detailed consideration of the experience of hoping itself. Our post-formal analysis denotes the tensions that are intrinsic and defining features of lifeworlds around hope, emphasising the dissonance and fragility of hoping. Drawing upon interview and observational data involving patients with advanced-cancer diagnoses who were taking part in clinical trials, we explore three main tensions which emerged within the analysis: tensions involving time and liminality between future and present; ontological tensions involving the concrete and the possible, the ‘realistic’ and the positive; and tensions in taken-for-grantedness between the reflective and the mundane, the specific and the ambiguous. Rather than three separate sets of tensions, those involving time, ontology and taken-for-grantedness are very much interwoven. In denoting the influence of social processes in engendering tensions, we bridge sociological and anthropological approaches with a more definition-oriented literature, developing understandings of hoping and its key characteristics in relation to other processes of coping amidst vulnerability and uncertainty.