Miracle-dz/UniFAR-FTUs huggingface dataset:
Barefoot running and hip kinematics: good news for the knee?

PURPOSE Patellofemoral pain and iliotibial band syndromes are common running injuries. Excessive hip adduction (HADD), hip internal rotation (HIR), and contralateral pelvic drop (CLPD) during running have been suggested as causes of injury in female runners. This study compared these kinematic variables during barefoot and shod running. METHODS Three-dimensional gait analyses of 23 habitually shod, uninjured female recreational athletes running at 3.33 m·s while shod and barefoot were studied. Spatiotemporal and kinematic data at initial contact (IC), 10% of stance (corresponding to the vertical impact peak), and peak angles were collected from each participant for HADD, HIR, and CLPD, and differences were compared across footwear conditions. RESULTS Step rates when running barefoot were 178 ± 13 versus 172 ± 11 steps per minute when shod (P < 0.001). Foot-strike patterns changed from a group mean heel-toe latency indicating a rear-foot strike (20.8 ms) when shod, to one indicating a forefoot strike (-1.1 ms) when barefoot (P < 0.001). HADD was lower at IC and at 10% of stance when running barefoot (2.3° ± 3.6° vs. 3.9° ± 4.0°, P < 0.001 and 2.8° ± 3.5° vs. 3.8° ± 3.7°, P < 0.01), as was HIR (7.9° ± 6.1° vs. 10.8° ± 6.1°, P < 0.001 and 4.1° ± 6.3° vs. 7.0° ± 5.8°, P < 0.01) and CLPD (0.4° ± 2.4° vs. -0.4° ± 2.3°, P < 0.01 and 0.8° ± 2.7° vs. 0.3° ± 2.5°, P < 0.05). There were no significant differences detected in peak data for hip kinematics. CONCLUSIONS Barefoot running resulted in lower HADD, HIR, and CLPD when compared to being shod at both IC and 10% of stance, where the body's kinetic energy is absorbed by the lower limb. Because excessive HADD, HIR, and CLPD have been associated with knee injuries in female runners, barefoot running could have potential for injury prevention or treatment in this cohort.
Research on the Setting of Restricted Stock for Listed Companies: A Case Study of Huamai Technology Company in Nanjing

The essay takes the restricted stock incentive scheme of Huamai Technology Company as the research object, and the feasibility of stock incentive scheme of Huamai Technology Company has been studied and analyzed by using exploratory case study method. It is found that the restricted stock scheme of the company has a single setting condition, which fails to reflect the management level of the enterprise. Therefore, considering the setting of restricted stock of listed companies will affect the company’s future performance, this paper puts forward countermeasures and suggestions for the conditional diversification of restricted stock of listed companies.
Chemotherapy for Invasive Bladder Cancer: Five Simple Rules Learned Over 30 Years

Abstract Invasive, clinically non-metastatic bladder cancer has a cure rate of only 50% , when all T stages are considered. The pattern of relapse is dominated by systemic spread, provided that optimal surgery is practiced. Occult metastases are thus most likely to be present at first presentation. For more than 30 years, therapeutic strategies have focused on the use of systemic chemotherapy before, during or after loco-regional therapy to produce cure. More aggressive surgery and more precise radiation techniques in addition to improved chemotherapy have also been tested to improve cure rates. Genetic analysis has focused on prediction and prognostication, without yet having a major impact on outcomes. New agents have been tested in the neoadjuvant and adjuvant setting, but have not yet proven superior to standard algorithms, such as neoadjuvant MVAC chemotherapy. Many studies have tested ineffective metastatic regimens in the neoadjuvant setting without success, giving rise to the maxim that ignoring logical rules of investigation will not advance clinical practice. Leveraging molecular prognostication and immune responsiveness of urothelial cancer may produce the next era of progress. Five simple rules are proposed to guide the development of future studies.
The Impact of Management the Structure of Agribusiness on Development of Economy: Evidence from Republic of Kosovo

In this paper, we investigate the impact of management the structure of agribusiness on economy as a direct influence on Kosovo's development and on the harmonization of people needs on rural areas. Also, the perceptions of farmers about the agribusiness. Using the principal component and regression analyses based on data obtained from 190 interviews with farmers’ ten different municipalities. The study reveals that farmers have high favorable perception of agribusiness, and the economic development is influenced by the type of modes management structure used, the harmonization of people needs on rural areas is not. Thus, the economic dimension improves as the farmers adopt a more coordinated type of mode management of structure. We conclude that farmers should adopt a more coordinated type of modes structure of management of their farms; this will contribute to the employment and overall development of economy.
The Research on Consumer Behavior of Online Games and Its Influencing Factors

The purpose of this paper is to explore consumer behavior of online game and its influencing factors by the methods of literature review and questionnaire analysis. The results show that the monthly consumption of online games by respondents exceeds RMB150, and its daily game time is about 3 hours. And the cognitions on the advantages, disadvantages, quality advantages, and quality disadvantages of online game and individual variables of player are all significant influencing factors on consumer behavior of online game. This paper suggests that the government should actively help domestic online games to develop their derivatives and export, and companies should make the differentiated marketing strategies for the consumer groups which divided by their different individual variables.
Clinical features of venous insufficiency and the risk of venous thrombosis in older people

Venous thrombosis is common in older age, with an incidence of 0·5–1% per year in those aged >70 years. Stasis of blood flow is an important contributor to the development of thrombosis and may be due to venous insufficiency in the legs. The risk of thrombosis associated with clinical features of venous insufficiency, i.e., varicose veins, leg ulcers and leg oedema, obtained with a standardized interview was assessed in the Age and Thrombosis Acquired and Genetic risk factors in the Elderly (AT‐AGE) study. The AT‐AGE study is a case–control study in individuals aged 70 years and older (401 cases with a first‐time venous thrombosis and 431 control subjects). We calculated odds ratios (ORs) and corresponding 95% confidence intervals (CI) adjusted for age, sex and study centre. Varicose veins and leg ulcer were associated with a 1·6‐fold (95% CI 1·2–2·3) and 3·3‐fold increased risk of thrombosis (95% CI 1·6–6·7), respectively, while the risk was increased 3·0‐fold (95% CI 2·1–4·5) in the presence of leg oedema. The risk of thrombosis was highest when all three risk factors occurred simultaneously (OR: 10·5; 95% CI 1·3–86·1). In conclusion, clinical features of venous insufficiency, i.e., varicose veins, leg ulcers and leg oedema, are risk factors for venous thrombosis in older people.
Public Sentiment and the Price of Corporate Sustainability

Combining environmental, social, and governance (ESG) data with “big data” measuring public sentiment about corporate sustainability performance, I found that the valuation premium for strong sustainability performance increases as a function of positive momentum in public sentiment. An ESG factor long (short) on companies with superior (inferior) sustainability performance and negative (positive) ESG sentiment momentum delivered significant positive alpha. In contrast, the high-sentiment ESG factor delivered insignificant alpha and was negatively correlated with the value factor. The evidence suggests that public sentiment influences investor views about the value of sustainability activities and that big ESG data can be useful in identifying “value” ESG stocks. Disclosure: The author is an academic partner at State Street Associates conducting research on ESG issues and sits on the advisory board of investment organizations that use ESG data. Editor’s Note: Submitted 29 Sep 2019 accepted 23 Jan 2020 by Stephen J. Brown.
Compassionate Use of Midostaurin in Myeloid and Lymphoid Neoplasia with FGFR1 Abnormality

Background: Patients with stem cell myeloproliferative disorders have a particularly poor prognosis and limited treatment options, i.e. mainly aggressive chemotherapy or allogeneic stem cell transplantation. In 2004, Chen et al. reported a patient presenting a t(8;13) (p11;q12) cytogenic anomaly who responded positively to treatment with PKC412 (midostaurin), an oral multi-targeted tyrosine kinase inhibitor. Here, we report a second case treated with the above-mentioned drug. Patient: A 71-year-old woman was diagnosed as having chronic myelogenous leukaemia with eosinophilia secondary to t(8;13) with FGFR1 involvement. Due to her age, an allogeneic stem cell transplantation was not possible. Treatment: A treatment combining aggressive chemotherapy and midostaurin was explored. The patient received one cycle of hyper-CVAD chemotherapy followed by maintenance therapy with midostaurin. A relapse occurred after six months, and she was treated with four more cycles of hyper-CVAD chemotherapy. The patient entered a complete clinical, haematological and cytogenetic remission. A maintenance therapy with midostaurin continued for four months until she developed a chemoresistant relapse followed by acute leukaemia. Conclusion: This is the second case of a t(8;13) myeloid and lymphoid neoplasm with FGFR1 abnormalities treated successfully with midostaurin. Midostaurin is administered orally, allows for outpatient care and in this case showed only occasional and minimal side effects. The combination of hyper-CVAD and midostaurin extended survival by 21 months without allogeneic transplantation. This case further supports the possibility of using midostaurin for the treatment of other diseases with FGFR1 dysregulations; however, specific clinical trials are needed to confirm this hypothesis.
Isolation and Purification of Treponema pallidum from Syphilitic Lesions in Rabbits

Treponema pallidum were extracted from testicular syphilomas of corticosteroid-treated rabbits and purified by differential centrifugation. The steroid therapy allowed a longer holding time for infected rabbits, which produced greater treponeme yields, averaging 1.58 × 1010 treponemes per rabbit. The treatment, which also diminished cellular infiltration and increased the extracellular mucoid material in lesions, produced much cleaner suspensions than preparations from nontreated animals. Most of the treponemes in the purified suspensions were still motile, and none carried demonstrable host immunoglobulin. The preparations were free of recognizable host tissue debris and they contained, on the average, 1.9 × 10−7 μg of protein per treponeme.
High-Sensitivity Ground Radiation Antenna System Using an Adjacent Slot for Bluetooth Headsets

In this communication, we introduce a high-sensitivity antenna system for Bluetooth headsets dealing with the numerous and unidentified noises in a printed circuit board (PCB). This antenna system is composed of a ground radiation antenna for Bluetooth applications and an adjacent slot for noise suppression. A loop-type circuit is used to model a noise source on the PCB to provide wide-frequency spectrum noise currents to analyze the noise performance of the high-sensitivity antenna system. Decoupling between the noise sources and the antenna port can lead to high sensitivity. An adjacent slot is designed as part of the system to improve the sensitivity, based on the decoupling theorem. This proposed system is effective and applicable for high-sensitivity antenna design, as verified through simulation and active measurements of Bluetooth headsets.
Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S.

OBJECTIVE The International Diabetes Federation (IDF) has proposed a new definition of the metabolic syndrome that emphasizes central adiposity as determined by ethnic group-specific thresholds of waist circumference. The objective of this study was to estimate the prevalence of this syndrome using the IDF definition among U.S. adults and to compare it with the prevalence estimated using the definition of the National Cholesterol Education Program (NCEP). RESEARCH DESIGN AND METHODS A total of 3,601 men and women aged > or =20 years from the National Health and Nutrition Examination Survey 1999-2002 were included in the analyses. RESULTS Based on the NCEP definition, the unadjusted prevalence of the metabolic syndrome was 34.5 +/- 0.9% (percent +/- SE) among all participants, 33.7 +/- 1.6% among men, and 35.4 +/- 1.2% among women. Based on the IDF definition, the unadjusted prevalence of the metabolic syndrome was 39.0 +/- 1.1% among all participants, 39.9 +/- 1.7% among men, and 38.1 +/- 1.2% among women. The IDF definition led to higher estimates of prevalence in all of the demographic groups, especially among Mexican-American men. The two definitions similarly classified approximately 93% of the participants as having or not having the metabolic syndrome. CONCLUSIONS In the U.S., the use of the IDF definition of the metabolic syndrome leads to a higher prevalence estimate of the metabolic syndrome than the estimate based on the NCEP definition.
Meshless Local Petrov-Galerkin Method in Anisotropic Elasticity

A meshless method based on the local Petrov-Galerkin approach is proposed for solution of static and elastodynamic problems in a homogeneous anisotropic medium. The Heaviside step function is used as the test functions in the local weak form. It is leading to derive local boundary integral equations (LBIEs). For transient elastodynamic problems the Laplace transfor technique is applied and the LBIEs are given in the Laplace transform domain. The analyzed domain is covered by small subdomains with a simple geometry such as circles in 2-d problems. The final form of local integral equations has a pure contour character only in elastostatics. In elastodynamics an additional domain integral is involved due to inertia terms. The moving least square (MLS) method is used for approximation of physical quantities in LBIEs. keyword: meshless method, local weak form, Heaviside step function, moving least squares interpolation, Laplace transform
Leadership styles across hierarchical levels in nursing departments.

BACKGROUND Some researchers have reported on the cascading effect of transformational leadership across hierarchical levels. One study examined this effect in nursing, but it was limited to a single hospital. OBJECTIVES To examine the cascading effect of leadership styles across hierarchical levels in a sample of nursing departments and to investigate the effect of hierarchical level on the relationships between leadership styles and various work outcomes. METHODS Based on a sample of eight hospitals, the cascading effect was tested using correlation analysis. The main sources of variation among leadership scores were determined with analyses of variance (ANOVA), and the interaction effect of hierarchical level and leadership styles on criterion variables was tested with moderated regression analysis. RESULTS No support was found for a cascading effect of leadership across hierarchical levels. Rather, the variation of leadership scores was explained primarily by the organizational context. Transformational leadership had a stronger impact on criterion variables than transactional leadership. Interaction effects between leadership styles and hierarchical level were observed only for perceived unit effectiveness. CONCLUSIONS The hospital's structure and culture are major determinants of leadership styles.
Automatic Course Website Discovery from Search Engine Results

With the rapid development of Internet Technology, the forms of education have been undergoing drastic changes. Instructors are used to posting teaching materials on course websites and setting them publicly accessible. Thus large amounts of course resources have been well organized and shared, which also provide possibilities for building knowledge graphs for a specific domain. However, so far no specific method has been developed for collecting online course resources. In this paper, we propose a method to identify course websites by filtering search results from a general search engine. Experiment results show that the proposed method could achieve good performances on both within-domain and cross-domain tasks, which lays a solid foundation for further work on mining and integrating the online educational resources.
Lactobacillus probiotic use in cardiothoracic transplant recipients: a link to invasive Lactobacillus infection?

M. ‐L. Luong, B. Sareyyupoglu, M.H. Nguyen, F.P. Silveira, R.K. Shields, B.A. Potoski, W.A. Pasculle, C.J. Clancy, Y. Toyoda. Lactobacillus probiotic use in cardiothoracic transplant recipients: a link to invasive Lactobacillus infection? Transpl Infect Dis 2010: 12: 561–564. All rights reserved
Scattering of rare-gas atoms at a metal surface: Evidence of anticorrugation of the helium-atom potential energy surface and the surface electron density.

Recent measurements of the scattering of He and Ne atoms at Rh(110) suggest that these two rare-gas atoms measure a qualitatively different surface corrugation: While Ne atom scattering seemingly reflects the electron-density undulation of the substrate surface, the scattering potential of He atoms appears to be anticorrugated. An understanding of this perplexing result is lacking. In this paper we present density functional theory calculations of the interaction potentials of He and Ne with Rh(110). We find that, and explain why, the nature of the interaction of the two probe particles is qualitatively different, which implies that the topographies of their scattering potentials are indeed anticorrugated.
High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype.

OBJECTIVE To evaluate cerebrospinal fluid (CSF) levels of amyloid beta protein ending at amino acid 42 (Abeta42) and tau as markers for Alzheimer disease (AD) and to determine whether clinical variables influence these levels. DESIGN Cohort study. SETTING Six academic research centers with expertise in dementia. SUBJECTS Eighty-two patients with probable AD, including 24 with very mild dementia (Mini-Mental State Examination score >23/30) (AD group); 60 cognitively normal elderly control subjects (NC group); and 74 subjects with neurological disorders, including dementia (ND group). MAIN OUTCOME MEASURES Levels of Abeta42 and tau were compared among AD, NC, and ND groups. Relationships of age, sex, Mini-Mental State Examination score, and apolipoprotein E (Apo E) genotype with these levels were examined using multiple linear regression. Classification tree models were developed to optimize distinguishing AD from NC groups. RESULTS Levels of Abeta42 were significantly lower, and levels of tau were significantly higher, in the AD group than in the NC or ND group. In the AD group, Abeta42 level was inversely associated with Apo E epsilon4 allele dose and weakly related to Mini-Mental State Examination score; tau level was associated with male sex and 1 Apo E epsilon4 allele. Classification tree analysis, comparing the AD and NC subjects, was 90% sensitive and 80% specific. With specificity set at greater than 90%, the tree was 77% sensitive for AD. This tree classified 26 of 74 members of the ND group as having AD. They had diagnoses difficult to distinguish from AD clinically and a high Apo E epsilon4 allele frequency. Markers in CSF were used to correctly classify 12 of 13 patients who later underwent autopsy, including 1 with AD not diagnosed clinically. CONCLUSIONS Levels of CSF Abeta42 decrease and levels of CSF tau increase in AD. Apolipoprotein E epsilon4 had a dose-dependent relationship with CSF levels of Abeta42, but not tau. Other covariates influenced CSF markers minimally. Combined analysis of CSF Abeta42 and tau levels discriminated patients with AD, including patients with mild dementia, from the NC group, supporting use of these proteins to identify AD and to distinguish early AD from aging. In subjects in the ND group with an AD CSF profile, autopsy follow-up will be required to decide whether CSF results are false positive, or whether AD is a primary or concomitant cause of dementia.
Complex signal interactions involving acetylcholine, muscarinic type 2 receptors, ATP and prostaglandins in the lamina propria: a ‘dangerous’ hypothesis

Hypothesis / aims of study The urothelium releases acetylcholine (Ach), ATP, Nitric Oxide (NO) and prostaglandin (PG). The physiological role of these signals is poorly understood and a possible interaction between them has not been considered. The aim of this study was to characterise the cholinergic system. The presence of both M2 and M3 muscarinc receptors in the lamina propria is not in doubt. The receptors are found in high abundance (M2>M3) but their physiological roles are poorly understood. One idea is that acetylcholine is released when the bladder is stretched and activates receptors on afferent nerve fibres to affect sensation [1]. However muscarinic receptors are found on other cell types e.g. sub-urothelial interstitial cells [2]. These cells also express a number of physiological and immunological receptors and appear to be a point of signal integration in this region of the bladder wall. It has recently been shown that ATP can regulate PG release from a preparation of the isolated lamina propria [3]. This preparation allows the possibility to explore other signal interactions in the lamina propria. The present study uses the isolated lamina propria preparation to study the effects of muscarininc stimulation on prostaglandin signalling. The predominant urothelial signals, ATP, PGE2, NO and ACh are associated in many systems with early inflammation. The output of urothelial signals has been found to occur through a number of complex interactions. The modulated urothelial output is targeted at the sub-urothelial interstitial cells which are known to express an array of cytokines. Therefore, we explored the idea that ATP, PGE2, NO and ACh regulate levels of expression of early inflammatory cytokines IL-
Hydrogen chemisorption on Si(111)7 x 7 studied with surface-sensitive core-level spectroscopy and angle-resolved photoemission.

Les resultats des mesures impliquent que la phase monohydrure est formee dans la maille elementaire 7×7 apres exposition a l'hydrogene. On pense, en contradiction avec des travaux anterieurs, que la composante de surface, qui se deplace vers une energie de liaison inferieure, correspond aux atomes au repos et non aux atomes adsorbes
Tax Incentives of Demand for Insurance Market Services in Russia

The article is devoted to the tax methods of stimulation of organization’s and individual’s financial initiatives in the field of insurance in Russia. The article describes the main problems and factors of insurance market development in Russia, summarizes the scientist’s points of view of such factors. It was determined that tax methods of regulation can influence the interaction of participants of economic relations. In article specified the types of preferences offered by the Russian legislation, organizations and individuals – participants of the insurance market. The tendencies of using tax preferences in purchasing insurance market products are analyzed. It was concluded that there are many disputable aspects of the application of tax preferences by organizations and individuals in Russia. It is revealed that in Russia there are no tax incentives for the development of voluntary property insurance for individuals and liability insurance for organizations, and of individual medical insurance. The direction of development and adaptation of preferences to modern conditions are