Miracle-dz/UniFAR-FTUs huggingface dataset:
Walking with robot assistance: the influence of body weight support on the trunk and pelvis kinematics

Abstract Purpose: The goal was to assess in healthy participants the three-dimensional kinematics of the pelvis and the trunk during robot-assisted treadmill walking (RATW) at 0%, 30% and 50% body weight support (BWS), compared with treadmill walking (TW). Methods: 18 healthy participants walked (2 kmph) on a treadmill with and without robot assistance (Lokomat; 60% guidance force; 0%, 30% and 50% BWS). After an acclimatisation period (four minutes), trunk and pelvis kinematics were registered in each condition (Polhemus Liberty™ [240 Hz]). The results were analysed using a repeated measures analysis of variance with Bonferroni correction, with the level of suspension as within-subject factor. Results: During RATW with BWS, there were significantly (1) smaller antero-posterior and lateral translations of the trunk and the pelvis; (2) smaller antero-posterior flexion and axial rotation of the trunk; (3) larger lateral flexion of the trunk; and (4) larger antero-posterior tilting of the pelvis compared with TW. Conclusions: There are significant differences in trunk and pelvis kinematics in healthy persons during TW with and without robot assistance. These data are relevant in gait rehabilitation, relating to normal balance regulation. Additional research is recommended to further assess the influence of robot assistance on human gait. Implications for Rehabilitation The trunk and pelvis moves in a different way during walking with robot assistance. The data suggest that the change in movement is due to the robot device and the harness of the suspension system more than due to the level of suspension itself.
Transition zone prostate cancer: detection and localization with 3-T multiparametric MR imaging.

PURPOSE To retrospectively compare transition zone (TZ) cancer detection and localization accuracy of 3-T T2-weighted magnetic resonance (MR) imaging with that of multiparametric (MP) MR imaging, with radical prostatectomy specimens as the reference standard. MATERIALS AND METHODS The informed consent requirement was waived by the institutional review board. Inclusion criteria were radical prostatectomy specimen TZ cancer larger than 0.5 cm(3) and 3-T endorectal presurgery MP MR imaging (T2-weighted imaging, diffusion-weighted [DW] imaging apparent diffusion coefficient [ADC] maps [b < 1000 sec/mm(2)], and dynamic contrast material-enhanced [DCE] MR imaging). From 197 patients with radical prostatectomy specimens, 28 patients with TZ cancer were included. Thirty-five patients without TZ cancer were randomly selected as a control group. Four radiologists randomly scored T2-weighted and DW ADC images, T2-weighted and DCE MR images, and T2-weighted, DW ADC, and DCE MR images. TZ cancer suspicion was rated on a five-point scale in six TZ regions of interest (ROIs). A score of 4-5 was considered a positive finding. A score of 4 or higher for any ROI containing TZ cancer was considered a positive detection result at the patient level. Generalized estimating equations were used to analyze detection and localization accuracy by using ROI-receiver operating characteristics (ROC) curve analyses for the latter. Gleason grade (GG) 4-5 and GG 2-3 cancers were analyzed separately. RESULTS Detection accuracy did not differ between T2-weighted and MP MR imaging for all TZ cancers (68% vs 66%, P = .85), GG 4-5 TZ cancers (79% vs 72%-75%, P = .13), and GG 2-3 TZ cancers (66% vs 62%-65%, P = .47). MP MR imaging (area under the ROC curve, 0.70-0.77) did not improve T2-weighted imaging localization accuracy (AUC = 0.72) (P > .05). CONCLUSION Use of 3-T MP MR imaging, consisting of T2-weighted imaging, DW imaging ADC maps (b values, 50, 500, and 800 sec/mm(2)), and DCE MR imaging may not improve TZ cancer detection and localization accuracy compared with T2-weighted imaging. SUPPLEMENTAL MATERIAL http://radiology.rsna. org/lookup/suppl/doi:10.1148/radiol.12120281/-/DC1.
Bis-bibenzyls from the Cameroon Liverwort Marchantia debilis

Liverworts are rich sources of terpenoids and aromatic compounds among which bis-bibenzyls are well known for their wide spectrum of biological activities. This is the first report of chemical analysis of the African liverwort Marchantia debilis Goebel. From the methanol extract marchantinquinone-1′-methyl ether was newly isolated together with three known bis-bibenzyls, marchantin C, marchantinquinone and perrottetin E. The presence of bis-bibenzyls with a quinone moiety is noted for the first time in the Marchantia genus.
Longitudinal changes of right ventricular deformation mechanics during trastuzumab therapy in breast cancer patients

Trastuzumab improves dramatically the prognosis of HER2‐positive breast cancer patients, but it may lead to cardiotoxicity with left ventricular (LV) systolic dysfunction. Its effects on right ventricular (RV) function have not however been elucidated. We sought to assess LV and RV deformation mechanics during treatment with trastuzumab in breast cancer patients.
Role of p90RSK in Kidney and Other Diseases

The 90 kDa ribosomal s6 kinases (RSKs) are a group of serine/threonine kinases consisting of 4 RSK isoforms (RSK1-4), of which RSK1 is also designated as p90RSK. p90RSK plays an important role in the Ras-mitogen-activated protein kinase (MAPK) signalling cascade and is the direct downstream effector of Ras-extracellular signal-regulated kinase (ERK1/2) signalling. ERK1/2 activation directly phosphorylates and activates p90RSK, which, in turn, activates various signalling events through selection of different phosphorylation substrates. Upregulation of p90RSK has been reported in numerous human diseases. p90RSK plays an important role in the regulation of diverse cellular processes. Thus, aberrant activation of p90RSK plays a critical role in the pathogenesis of organ dysfunction and damage. In this review, we focus on the current understanding of p90RSK functions and roles in the development and progression of kidney diseases. Roles of p90RSK, as well as other RSKs, in cardiovascular disorders and cancers are also discussed.
Downregulation of lncRNA TUG1 contributes to the development of sepsis‐associated acute kidney injury via regulating miR‐142‐3p/sirtuin 1 axis and modulating NF‐κB pathway

This study intended to investigate the potential molecular mechanism of long noncoding RNA (lncRNA) taurine upregulated gene 1 (TUG1) in the development of sepsis‐associated acute kidney injury (AKI). The expression of TUG1 in the serum from patients with sepsis resulted in AKI, and healthy controls were analyzed. First, we used lipopolysaccharide (LPS; to induce AKI rat mesangial cells (RMCs) for establishing the septic AKI model in RMCs. Subsequently, TUG1 was overexpressed in RMCs and the influences of overexpression of TUG1 on cell biological processes (viability, apoptosis, and autophagy) and cytokines secretion in LPS‐associated RMCs were investigated. Furthermore, the interaction between TUG1 and miR‐142‐3p was investigated, and the target of miR‐142‐3p was predicted. Also, whether TUG1 could regulate the activation of nuclear factor κB (NF‐κB) signal was investigated. The results showed that TUG1 was lowly expressed in the serum patients with sepsis‐associated AKI compared with that in the controls. In addition, overexpression of TUG1 relieved the injury induced by LPS in RMCs. Moreover, miR‐142‐3p was negatively regulated by TUG1, and TUG1 upregulation restrained LPS‐associated injury by suppression of miR‐142‐3p. Sirtuin 1 (SIRT1) was identified as a target of miR‐142‐3p, which could be negatively regulated by miR‐142‐3p. Furthermore, overexpression of TUG1 suppressed the activation of NF‐κB signal in RMCs, which was markedly reversed after miR‐142‐3p upregulation. Our findings reveal that downregulation of lncRNA TUG1 may promote the development and progression of sepsis‐associated AKI via regulating miR‐142‐3p/SIRT1 axis and modulating NF‐κB signal.
Energetics of migratory bats during stopover: a test of the torpor-assisted migration hypothesis

ABSTRACT The torpor-assisted migration hypothesis posits that migration is facilitated in bats by the use of torpor during stopover roosting periods, and predicts that at stopover, bats regulate time in torpor facultatively so that daily energy expenditure is independent of ambient roosting temperature. Energy savings can thus be directed to migratory movement. However, direct measurements of total roosting energy expenditure in relation to ambient and body temperature are lacking. We captured migratory silver-haired bats (Lasionycteris noctivagans; ∼11 g) at Long Point, ON, Canada, in spring and autumn 2016. We used quantitative magnetic resonance analysis to measure body composition change and energy expenditure over a 12 h roosting period in a ventilated incubator at 10, 17 and 25°C. We assessed the effects of season, body mass, sex and age on energy expenditure. We found that daily energy expenditure was independent of roosting temperature, and that this was achieved by flexible use of torpor. Variation in body mass at capture was driven mainly by differences in fat, and the amount of body fat was negatively related to torpor use, particularly in spring. Season, sex and age also affected torpor use and energy expenditure, notably with pregnant females being generally fatter and using less torpor than males in spring. We estimate that stopover contributes only 15–20% to the total energy costs of migration in bats compared with 70% or more in typical birds. This study provides support for the torpor-assisted migration hypothesis, and furthers our understanding of the energy budgets of migratory bats. Highlighted Article: The total energy expended by migratory bats during daytime roosting at stopovers is independent of ambient temperature as a result of facultative adjustment of torpor.
metagenomeFeatures: An R package for working with 16S rRNA reference databases and marker-gene survey feature data

We developed the metagenomeFeatures R Bioconductor package along with annotation packages for the three primary 16S rRNA databases (Greengenes, RDP, and SILVA) to facilitate working with 16S rRNA sequence databases and marker-gene survey feature data. The metagenomeFeatures package defines two classes, MgDb for working with 16S rRNA sequence databases, and mgFeatures for working with marker-gene survey feature data. The associated annotation packages provide a consistent interface to the different 16S rRNA databases facilitating database comparison and exploration. The mgFeatures represents a crucial step in the development of a common data structure for working with 16S marker-gene survey data in R. Availability https://bioconductor.org/packages/release/bioc/html/metagenomeFeatures.html Contact nolson@nist.gov
The Emergency Department Response to Women Experiencing Intimate Partner Violence: Insights From Interviews With Clinicians in Australia.

BACKGROUND AND OBJECTIVES Emergency departments (EDs) are essential providers of compassionate, immediate treatment and referral for women experiencing intimate partner violence (IPV). IPV, largely perpetrated by men against women, exerts a substantial burden on the health systems and economies of all nations. There is little known about how staff in Australian EDs respond to the challenges such violence generates. We therefore examined the clinical team response to women experiencing IPV in two large Australian metropolitan hospital EDs. METHODS We undertook qualitative semistructured interviews and focus group discussions with 35 social workers, nurses, and doctors. Transcripts were recorded and transcribed verbatim. We analyzed the data thematically. We first undertook line-by-line coding and organized content into descriptive categories. Latent and manifest patterns were identified across the data and mapped to key themes in negotiation with all authors. RESULTS Respondents emphasized challenges identifying IPV resulting from professional uncertainty or discomfort and women's fear of the ramifications of disclosure. Emergency clinicians routinely referred women to social workers after medical treatment and described effective collaboration across professions. Social workers outlined difficulties coordinating care with health and community agencies. Staff highlighted challenges maintaining nonjudgmental attitudes and managing their own feelings-especially clinicians who had personally experienced violence. CONCLUSIONS Emergency departments can provide caring environments for women experiencing IPV. Effective interprofessional teamwork across nursing, medical, and social work professionals may mitigate the need for formal screening tools. Supportive workforce environments can improve staff understanding, reduce stigma, enhance appropriate treatment, and counsel health professionals experiencing violence. However, staff training and advocacy and referral relationships with local programs require strengthening. A connected multisystems-level response is required to coordinate and resource services for all affected by violence.
miR-17-5p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting phosphatase and tensin homolog

Glaucoma is one of the leading causes of blindness. Previous studies have indicated that the oxidative stress-induced apoptosis of trabecular meshwork cells (TMCs) may serve a key role in the pathogenesis of glaucoma, and that micro RNA(miR)-17-5p may be involved in this process. However, the specific mechanisms require further investigation. The aim of the present study was to investigate the effects of miR-17-5p on the proliferation and apoptosis of human TMCs (HTMCs) in response to oxidative stress. It was observed that exposure to H2O2 induced a significant decrease in the proliferation and a marked increase in the apoptosis of HTMCs. H2O2 exposure also suppressed the expression of miR-17-5p and promoted the expression of phosphatase and tensin homolog (PTEN). Furthermore, transient overexpression of miR-17-5p induced a significant increase in the proliferation and a significant decrease in the apoptosis of HTMCs by affecting the expression of PTEN, and the apoptosis-related proteins B-cell lymphoma-associated X protein (Bax), B-cell lymphoma-extra large (Bcl-xL) and B-cell lymphoma-2 (Bcl-2). However, knockdown of miR-17-5p demonstrated the opposite results. The results of a dual luciferase reporter assay demonstrated that PTEN may be a direct target of miR-17-5p. In conclusion, miR-17-5p was downregulated in HTMCs under oxidative conditions, and miR-17-5p may regulate the apoptosis of HTMCs by targeting PTEN. These results provide a novel theoretical basis and potential therapeutic target for the treatment of glaucoma.
Invasive Ductal Carcinoma Arising in Mucinous Cystic Neoplasm of Pancreas: A Case Report

Patient: Female, 40 Final Diagnosis: Invasive ductal carcinoma arising in mucinous cystic neoplasm of pancreas Symptoms: None Medication: — Clinical Procedure: Surgical resection Specialty: Oncology Objective: Rare co-existance of disease or pathology Background: Mucinous cystic neoplasm (MCN) of the pancreas is a rare mucin-producing cystic neoplasm that has a characteristic histological feature referred to as ovarian-type stroma (OS) underlying the epithelium. Pancreatic ductal carcinoma arises from MCN as a precursor lesion, but data on progression pathways are limited. Case Report: A 40-year-old female was referred to our hospital for further investigation of a pancreatic cyst. Further examination showed a 7.0 cm multilocular cyst in the pancreatic tail and a solid mass in the thick septum of the cystic tumor. Distal pancreatectomy and splenectomy were performed. Histological examination revealed a moderately differentiated invasive ductal carcinoma (IDC) with a diameter of 0.5 cm in the thick septum of the cystic lesion and a cyst wall composed of epithelium with low-grade to severe dysplasia. The epithelium covered an OS. Pathological diagnosis was IDC arising in MCN of the pancreas. Immunohistochemical examination showed that MUC1 expression was negative in MCN but positive in IDC. KRAS mutation was observed in both MCN and IDC regions. Conclusions: We present a rare case of moderately differentiated pancreatic IDC arising in MCN. To elucidate the underlying progression pathway, we explored the correlation between KRAS mutation and MUC expression as a clinico-pathological parameter.
Expecting and Competing? Jealous Responses Among Pregnant and Nonpregnant Women

In the current study, we reasoned that when pregnant, women should be especially motivated to protect their reproductive investments as well as their pair bond and be vigilant about intrasexual competitors. To investigate this, pregnant women (n = 66) and nonpregnant women (n = 59; age M = 27.41, SD = 3.36) in committed relationships read a jealousy-evoking scenario that was accompanied by a picture of either an attractive or an unattractive woman, after which they indicated their jealousy about such a situation. Moreover, we asked whether a mate’s emotional infidelity would evoke more jealousy than his sexual infidelity. The results showed that for pregnant women, both rivals evoked similar amounts of jealousy, whereas nonpregnant women’s jealousy was mainly evoked by the attractive rival. Moreover, pregnant women indicated they would be most upset by their partner’s emotional infidelity, and especially if they were previously exposed to the attractive rival. Nonpregnant women considered both types of infidelity equally upsetting. These results emphasize the adaptive function of jealousy and extend the literature on the influence of a rival’s attractiveness on women’s jealousy by focusing on the experiences of pregnant women.
A Review of Advanced Localization Techniques for Crowdsensing Wireless Sensor Networks

The wide availability of sensing modules and computing capabilities in modern mobile devices (smartphones, smart watches, in-vehicle sensors, etc.) is driving the shift from mote-class wireless sensor networks (WSNs) to the new era of crowdsensing WSNs. In this emerging paradigm sensors are no longer static and homogeneous, but are rather worn/carried by people or cars. This results in a new type of wide-area WSN—crowd-based and overlaid on top of heterogeneous communication technologies—that paves the way for very innovative applications. To this aim, the positioning of mobile devices operating in the network becomes crucial. Indeed, the pervasive, almost ubiquitous availability of smart devices brings unprecedented opportunities but also poses new research challenges in their precise location under mobility and dense-multipath environments typical of urban and indoor scenarios. In this paper, we review recent advances in the field of wireless positioning with focus on cooperation, mobility, and advanced array processing, which are key enablers for the design of novel localization solutions for crowdsensing WSNs.
Knockdown of HIP1 expression promotes ligand-induced endocytosis of EGFR in HeLa cells

Huntington-interacting protein 1 (HIP1) is associated with various tumor types; however, its precise functions in tumor cells are unclear. In this study, the effects of HIP1 on the degradation of EGFR, which have important roles in carcinogenesis after EGF stimulation, were examined. After screening 17 cell lines, the coexpression of HIP1 and EGFR was detected in HeLa cells. Accordingly, the expression of HIP1 was knocked down in HeLa cells using various HIP1 siRNA sequences. The endocytosis of EGFR and localization of clathrin in HeLa cells were examined after stimulation by EGF at various concentrations (i.e., 1.5 and 100 ng/ml). After HIP1 expression was blocked by siRNAs, EGFR endocytosis was accelerated and this effect was dependent on the EGF concentration. This endocytosis was colocalized with clathrin expression. These findings indicate that the inhibition of HIP1 can accelerate the endocytosis and degradation of EGFR. Furthermore, they suggest that HIP1 is a potential therapeutic target for various cancer types, particularly those with high EGFR expression, but further research is needed to examine this hypothesis.
Are changes in running economy associated with changes in performance in runners? A systematic review and meta-analysis

ABSTRACT Improvements in running economy (RE) are thought to lead to improvements in running performance (P). Multiple interventions have been designed with the aim of improving RE in middle and long-distance runners. The aim of this study was to assess the effect of interventions of at least 2-weeks’ duration on RE and P and to determine whether there is a relationship between changes in RE (ΔRE) and changes in running performance (ΔP). A database search was carried out in Web of Science, Scopus and SPORTDiscus. In accordance with a PRISMA checklist 10 studies reporting 12 comparisons between interventions and controls were included in the review. There was no correlation between percentage ΔRE and percentage ΔP (r = 0.46, P = 0.936, 12 comparisons). There was a low risk of reporting bias but an unclear risk of bias for other items. Meta-analyses found no statistically significant differences between interventions and controls for RE (SMD (95% CI) = −0.37 (−1.43, 0.69), 204 participants, p = 0.49) or for P (SMD (95% CI) = −0.65 (−26.02, 24.72, 204 participants, p = 0.99). There is a need for studies of greater statistical power, methodological quality, duration and homogeneity of intervention and population. Standardised measures of performance and greater control over non-intervention training are also required.
Adsorption Thermodynamics and Dynamics of Three Typical Dyes onto Bio-adsorbent Spent Substrate of Pleurotus eryngii

Dyeing wastewater is very hard to treat, and adsorption could be a good choice. Spent substrate of Pleurotus eryngii (SSPE) was first used to adsorb malachite green, safranine T and methylene blue from aqueous solutions, and the corresponding adsorption isotherm, thermodynamics and dynamics models were simulated. More than 93% of the dyes were removed with solutions with 100 mg/L of initial dye concentration, 1 g of SSPE and pH of 6.0 after adsorption for 4 h. Freundlich isotherm models fit better the adsorption data than Langmuir models. Adsorption of the dyes onto SSPE was a spontaneous exothermic process based on an adsorption thermodynamics model. SSPE could adsorb the dyes rapidly, and a second-order kinetics model fit better with the adsorption data than a pseudo first-order kinetics model. Accordingly, SSPE could be a good bio-adsorbent for the removal of malachite green, safranine T and methylene blue from the aqueous solution.