Miracle-dz/UniFAR-FTUs huggingface dataset:
Didox‐A Multipotent Drug for Treating Demyelinating disease

Chronic experimental allergic encephalomyelitis (EAE) is an animal model for multiple sclerosis the most common demyelinating disease. Didox is a polyhydroxyphenol which can inhibit biological activities important for the progression of EAE. After induction of chronic EAE, didox was given daily to C57Bl/6 mice either by intraperitoneal injection (275 mg/kg) or by oral gavage (550 mg/kg in carboxymethylcellulose); mice were evaluated daily for clinical severity (stage 4=maximum severity). Didox given prior to the onset of disease, delayed the onset and reduced the severity of disease. Didox given at the peak of disease completed reversed clinical symptoms. Didox given one week after peak disease reduced clinical symptoms from 4 to 2. In a dose dependent manner didox inhibited peripheral T‐cell proliferation, secretion of both IFN‐gamma and Il‐17a by activated T‐cells and secretion of nitrite by microglia. Morphological examination of the CNS of didox‐treated mice which had reversed from stage 4 to stage 0 revealed preservation of axons and myelin similar to what was observed in the CNS of mice when they initially reached stage 4. EM analysis of didox treated animals revealed lymphocytes trapped in the perivascular space. The pleotrophic effects of didox make it an ideal candidate for demyelinating disease therapy. (Supported by the Dept. Veterans Affairs and Molecules for Health, Richmond, VA.)
ANTI-ULCER EFFECT OF COCCINIA GRANDIS (Linn.) ON PYLORUS LIGATED (ALBINO) RATS

The objective is to evaluate the anti‐ulcer activity of ethanolic, aqueous, total aqueous extracts of leaves of Coccinia grandis (Linn.) , Anti-ulcer activity of the three extracts was studied in rats by using pylorus ligated ulcer model and it was subjected to preliminary phytochemical studies for the identification of phytoconstituents and also studied for color, consistency and percentage yield of various extracts. Omeprazole was used as the standard drug for comparison. The animals were sacrificed after 19 hrs after the ligation. Stomach was dissected out and contents were drained into tubes and were centrifuged at 1000 rpm for 10min and volume was noted. The PH of gastric juice was recorded using a PH meter. The contents were subjected for analysis of free and total acidity and Na+, k+ ion concentration. The numbers of ulcers per stomach was noted and severity of ulcers scored. Then the blood samples were collected and subjected to estimation of serum calcium and alkaline phosphatase level. The expected result is to get an anti-ulcer activity of the leaf extracts of Coccinia grandis should owing to the presence of one or more phytoconstituents, which may reduce the acidity of the gastric juice and also prevents the mucosal damage and ulcer formation. The Ethanolic Extract 400mg/kg expected to showed comparable anti ulcer-activity as that of standard Omeprazole.
Progress in research on the comprehensive monitoring of forest resources

From the perspectives of the core concepts，the inventory and monitoring methods of forest resources were introduced，and the characteristics of national forest inventory at home and broad were compared． At the same time，the status quo of forest resources monitoring in the major developed forestry countries was analyzed． Based on the current conditions and existing problems in forest resources monitoring in China，according to the actual conditions and the social requirements for forest resources monitoring，the paper pointed out that the development trend and construction goal of forest resources comprehensive monitoring in China should be the diversification of monitoring content，annual monitoring period，the standardization of monitoring technology，the integration of monitoring measures and the sharing of monitoring information．［Ch，41 ref. ］
The effects of some factors on the diapause induction of Asian corn borer ( Ostrinia furnacalis )

This paper deals with the effects of food,temperature and photoperiod on the diapause of Asian corn borer, Ostrinia furnacalis (Guene'e). The results showed that the effects of different food on the diapause induction of Asian corn borer were significantly different.The sensitivity of diapause induction by photoperiod of the larvae fed by corn ear was stronger than that of the larvae fed by cotton boll.To some extent,higher concentration of soluble sugar in the food promoted the induction of larval diapause,while higher concentration of protein suppressed it.Higher temperature was favorable to suppress the induction of larval diapause,while lower temperature was favorable to the induction of diapause.There were not determined sensitive stages of larval diapause induction by short photoperiod,but the population was more sensitive in 2 and 3 instars.The induction effects by short photoperiod were additive.
The spatial distribution pattern of fishing ground for small yellow croaker in China Seas

The paper discusses the spatial variation of the small yellow croaker (Larimichthys polyactis) fishing ground annual changes in production and the dominance of fisheries according to the capture production of fishing in the Bohai Sea,Yellow Sea and East China Sea from 1971 to 1982. We also compared the locations of historical fishing grounds with the present locations and time,and we explored the spatial variation and the changes in fisheries. The results shows that there are three types of small yellow croaker fishing grounds,that is the spring spawning grounds which were mainly located in coastal waters,summer feeding grounds which were concentrated on the south of Yellow Sea and the north of East China Sea,and the wintering grounds which were concentrated on the central and southern offshore of Yellow Sea and northern nearshore of the East China Sea. The capture production of small yellow croaker in Bohai Sea had declined significantly since 1974 and the capture production in East China Sea was dominant since 1979. In addition,two kinds of distribution patterns of small yellow croaker were found. One is winter-summer (Dec,Jan.-Feb. Jul.-Sept.) pattern,composed of high-quality small yellow croaker fishing grounds for the stable locations located in the central and southern offshore of Yellow Sea and northern offshore of the East China Sea in winter and in the southern nearshore of Yellow Sea and the East China Sea in summer,intensive fish and concentrated production. The other is spring-autumn (Mar.-Jun. Oct.-Nov.) pattern,which was characterized by the low capture production for the small yellow croaker in the migratory period and it was not the predominant target species for capture. The spatial distribution pattern fishing grounds for small yellow croaker in 1971-1982 resemble the current,but it has important reference value to research on small yellow croaker in the characteristics of fishing grounds,fishing season and the contribution of fish distribution pattern mode.
Women Leaders and Pandemic Performance: A Spurious Correlation

Abstract The connection between women leaders and superior pandemic performance is likely spurious. This narrative overlooks that women currently govern precisely the kinds of countries that should mount effective pandemic responses: wealthy democracies with high state capacity. This article maps where women currently serve as presidents and prime ministers. The article then uses data from the Varieties of Democracy Project and the Organisation for Economic Co-operation and Development to show that many women-led countries score high on state capacity and that high-capacity states have low coronavirus mortality regardless of whether they are led by women or by men. Arguments emphasizing women chief executives’ superior pandemic performance, while offered in good faith, are misleading.
Future distribution of cotton and wheat in Australia under potential climate change

SUMMARY The present study applies refined and improved scenarios for climate change to quantify the effects of potential alterations in climatic factors on localities for wheat and cotton production, which are two crops important to Australia's economy. The future distributions of Gossypium (cotton) and Triticum aestivum L. (wheat) were modelled using CLIMEX software with the A2 emission scenario generated by CSIRO-Mk3·0 and MIROC-H global climate models. The results were correlated to identify areas suitable for these economically important crops for the years 2030, 2050, 2070 and 2100 in Australia. The analysis shows that the areas where wheat and cotton can be grown in Australia will diminish from 2030 to 2050 and 2070 through to 2100. While cotton can be grown over extensive areas of the country until 2070, the area grown to wheat will decrease significantly over the period.
Exploring the Use of Animal Assisted Therapy in School Counseling: Using AAT with Adolescents Who Have Internalizing Disorders

The purpose of this paper is to discuss current trends among adolescents with internalizing disorders such as anxiety and depression and to propose the use of animal assisted therapy to intervene with this population. Discussion will center on the use of animal assisted therapy in school counseling to supplement interventions for students who have internalizing disorders, as well as for use in classroom guidance. Types of therapy animals discussed at length will include be dogs and small mammals with a specific focus on dogs. In addition, this paper will examine the human-animal bond and the benefits of utilizing the human-animal bond in school counseling. The physiological and emotional impact that animals have on humans will be addressed. Considerations and suggestions for implementing and using therapy animals as tools to supplement a school counseling program will also be discussed. AAT IN SCHOOL COUNSELING iv Winona State University College of Education Counselor Education Department CERTIFICATE OF APPROVAL __________________________ CAPSTONE PROJECT ___________________ Exploring the Use of Animal Assisted Therapy in School Counseling: Using AAT with Adolescents Who Have Internalizing Disorders This is to certify that the Capstone Project of Leah Jagodzinski Has been approved by the faculty advisor and the CE 695 – Capstone Project Course Instructor in partial fulfillment of the requirements for the Master of Science Degree in Counselor Education Capstone Project Supervisor: Dr. Dawnette Cigrand Approval Date: December 10th, 2014 AAT IN SCHOOL COUNSELING v
Multidrug-resistant Acinetobacter septicemia in neonates: A study from a teaching hospital of Northern India

BACKGROUND: Acinetobacter species are typical nosocomial pathogens causing infections and high mortality, almost exclusively in compromised hospitalized patients. Acinetobacter sp. are intrinsically less susceptible to antibiotics and have propensity to acquire resistance. Multidrug-resistant (MDR) Acinetobacter sp. blood infection in the neonatal intensive care unit patients create a great problem in hospital settings. AIMS: A prospective data analysis was performed over a one year period of all neonates admitted with sepsis who developed Acinetobacter infection and their antibiotic susceptibility pattern was carried out. MATERIALS AND METHODS: Blood samples of infected neonates were collected aseptically and cases of Acinetobacter septicemia were identified. Speciation of Acinetobacter species was done. Various risk factors were identified and their drug-sensitivity test was performed. RESULTS: The incidence of neonatal septicemia due to Acinetobacter species was 13.7% (49/357). Predominant species isolated was Acinetobacter baumannii (98%). The major symptoms were lethargy and poor feeding. The major signs were tachypnea, intercostal retraction, and respiratory distress. The major fetal risk factors were low birth weight and prematurity. High degree of resistance was observed to the various antibiotics used. Majority of the isolates (95.9%) were MDR while 93.68% were resistant to carbapenems as well as extensively drug resistant. However, all the strains were sensitive to colistin. CONCLUSION: MDR Acinetobacter septicemia in neonatal patients is becoming alarmingly frequent and is associated with significant mortality and morbidity. Therefore, rational antibiotic use is mandatory along with an effective infection control policy in neonatal intensive care areas of each hospital to control Acinetobacter infection and improve outcome.
Rôle de la protéine FMRP dans la formation et le dynamisme des granules à ARN

La proteine de liaison a l’ARN, Fragile Mental Retardation Protein (FMRP) est une proteine conservee dans l'evolution et particulierement abondante dans le cerveau en raison de sa forte expression dans les neurones. L'absence de FMRP est responsable du syndrome du X Fragile, premiere cause du retard mental hereditaire. Cette proteine semble jouer un role important dans la regulation de la traduction des ARNm, puisqu’elle se retrouve sur les polyribosomes en traduction active. Elle se retrouve egalement dans des structures contenant des ARNm sous forme reprimee ce qui suggere qu’elle se comporte plutot comme une proteine ayant un role de represseur traductionnel. Il a deja ete montre que la surexpression de la proteine FMRP chez les mammiferes peut induire la formation de granules cytoplasmiques d'ARN qui ressemblent aux granules neuronaux et aux granules de stress. Les mecanismes de formation de ces granules FMRP et leur dynamisme sont cependant totalement inconnus. Contrairement a FMRP chez les mammiferes qui a deux homologues (FXR1 et FXR2), la drosophile possede un seul gene codant pour dFMRP. L'utilisation de ce modele simple nous a permis d’etudier la formation des granules dFMRP et le role de dFMRP dans la formation des granules de stress. Nous avons pu montrer que l'expression de dFMRP dans les cellules de la drosophile induit la formation de granules dynamiques. La formation de ces granules dFMRP se fait sans activation d’une reponse generale au stress et leur mecanisme de formation ne ressemble pas a celui des granules de stress. La formation de ces granules implique le domaine de dimerisation de dFMRP. Ce domaine ne semble cependant pas important pour le recrutement de la proteine dans les granules de stress. Nos experiences de FRAP montrent que le domaine de dimerisation de dFMRP est plutot necessaire a la mobilite de la proteine entre les granules de stress et le cytoplasme. Dans l'ensemble, nos etudes suggerent que la dimerisation de dFMRP est un evenement important pour l’induction des granules-dFMRP et permet le trafic de dFMRP entre les granules a ARN et le cytoplasme.
Binding of nBmp2 to PLSCR1 suggests a possible mechanism for nBmp2 regulation of Ca2+‐modulating proteins

Bone morphogenetic protein 2 (Bmp2) is a secreted growth factor that affects many aspects of development and differentiation. We have recently discovered a novel nuclear variant of Bmp2, called nBmp2. Mice lacking nBmp2 in the nucleus exhibit impaired intracellular handling of Ca2+ in skeletal muscle. To delineate the molecular connection between nBmp2 and Ca2+ management, a yeast two‐hybrid screen was performed which resulted in the identification of phospholipid scramblase 1 (Plscr1) as a protein that interacts with nBmp2. Plscr1 is known to bind a 15‐bp sequence in the promoter of the inositol triphosphate receptor 1 (ITPR1) gene, which codes for a Ca2+ channel, to activate its transcription. These results suggest that nBmp2 may affect Ca2+ transport in skeletal muscle by modulating the transcription of ITPR1 and possibly other genes that code for Ca2+ transport proteins. Research supportedby NIH/NIAMS grant #AR48839.
Cancer:a Proteomic Disease

The development of cancer is a pathological process involving multiple environmental carcinogenic factors and multiple genetic alterations in multiple steps.For the past decades,cancer researches have been focused on the genomic and transcriptomic analysis.The completion of the Human Genome Project has opened the door to the Post-Genome Era and oncoproteomics emerges as the times require.As the major direct executors of the gene functions,proteins play a critical role in tumorigenesis and determine the differences between normal cells and malignant cells including heterogeneity and malignant properties.This report first proposed the idea that cancer is a proteomic disease.The idea was elucidated following the aspects:protein expression profiling,post-translational modifications in proteins,protein-protein interactions and regulation of the interaction network in carcinogenesis based on the recent advances of expression proteomics,comparative proteomics,functional proteomics and structural proteomics.The idea provides a new way of looking at carcinogenesis,presents new clues in biomarker discovery for cancer diagnosis and therapy,and displays the great scientific significance and clinical application value.
Genetic variability, heritability and genetic advance analysis in segregating generation of blackgram {Vigna mungo (L.) hepper}

The genetic variability study was carried out in the segregating populations of three crosses. The cross LBG 645/LBG 20 recorded high estimates of PCV and GCV for plant height, number of branches per plant, number of seeds per pod and seed yield per plant. High heritability coupled with high genetic advance as per cent of mean were observed for plant height, number of branches per plant, number of clusters per plant and number of pods per plant. Number of pods per cluster recorded high heritability and high genetic advance in LBG 685/LBG 20. High heritability with high genetic advance for pod length in LBG 645/LBG 20.
Stroke Treatment Academic Industry Roundtable X: Brain Cytoprotection Therapies in the Reperfusion Era.

Neuroprotective strategies for acute ischemic stroke continue to show that they confer no benefit on primary clinical end points in randomized clinical trials. Scholarly reviews of the 30-year history of failures have revealed extensive shortcomings both in the preclinical and clinical development programs of most neuroprotective agents. Given the highly successful development of thrombectomy devices to improve clinical outcome in patients with large vessel occlusions (LVOs), there are new opportunities to restudy and repurpose previous neuroprotective agents as well as study and develop new neuroprotective agents as adjunctive treatments to reperfusion therapy. Accordingly, key stakeholders from academia and industry convened at the Stroke Treatment Academic Industry Roundtable X meeting in Washington, DC, in October 2017 to develop consensus recommendations intended to facilitate the successful translation of cerebroprotective therapies in the new era of highly effective reperfusion. To have maximum impact, this consensus article focuses on highly effective reperfusion with thrombectomy, while we also acknowledge that neuroprotective agents can and should be developed in conjunction with thrombolysis.
Insights in Plant-Microbe Interaction through Genomics Approach (Part 1)

For the last few decades, the constant striving to understand the mechanism of plant-microbe interaction has increased manifold, even though a lot of inaccessible information is yet to unfold. Ingress into such covered information can be a notable aid for mankind, particularly by helping plants fight against pathogens and other stresses. Crops are continuously exposed to many stresses, which may be abiotic or/and biotic. At times the interactivity of microbes with plants assists plants to stand against various environmental stresses; on the contrary, sometimes they act as stresses for plants. Plants are always at higher risks as most of the microbes interact with the plants to feed or to survive [1, 2]. There is an extensive range of beneficial microorganisms which play vital role in plant growth, development and survival [3]. These are most often known as agriculturally important microbes which not only help plants to get proper nutrients but also regulate the plant and other microbe interactions. Knowing the nature of microbe and its connection with particular plants be useful to control diseases in plants. There are several mechanisms for plant-microbe interactions which vary from plant to plant and microbe to microbe as well [4]. The interaction can materialize in any part of the plants, may it be underground or above the soil. It can also be both endophytic and epiphytic, depending on the microbes. In addition to these two major participants, it also relies on the environment neighboring the area where the interaction occurs.
Perfil epidemiológico e evolução clínica dos portadores de miocardiopatia dilatada acompanhados no serviço de cardiologia pediátrica de referência regional

Introduction: The dilated form of cardiomyopathies is the most common clinical picture in childhood, showing high morbidity and mortality and is a frequent indication of cardiac transplantations. Prognosis is improving with early diagnosis and treatment. However, even today, knowledge of the epidemiological profile is poor and limited. Objective: The aim of this study is to describe the epidemiological profile of dilated cardiomyopathy (DCM) diagnosticated between 0-12 years and to compare data of survivors and non-survivors patients. Method: A descriptive and retrospective study was conducted by reviewing the records of patients with DCM treated between 2005-2015. A descriptive analysis of ages, sexes, weights, body surfaces, family histories, clinical presentations, echocardiographic diagnostic data: systolic and diastolic diameters of the left ventricle, ejection fractions and shortening were carried out. The Student's t-test was applied to compare the paired variables with normal distribution and the test of the medians undertaken in the variables related to death and non-death, considering significant p < 0.05 values. Results: 40 patients were included with a mean age of 3.3 years, 65% were females and 52.5% in the first year of life. Heart failure predominated (80%). From 72.5% of survivors, 60% normalized cardiac function in 1.18 years, with partial recovery in 12.5%. Among 22.5% non-survivors, 17.5% died for DCM, 5% for extracardiac cause and the follow-up was lost in 5%. The final systolic diameter was significantly lower in the surviving group (p < 0.05). Conclusion: In this study it was possible to know the main epidemiological factors related to the evolution of DCM in childhoods. Improve the diagnosis and stratification of risk seeking new therapeutic options are necessary in the management of this disease.
Progression of Disease and Viral Agents in Infants Hospitalized for Lower Respiratory Tract Infections

Ad dress for Cor res pon den ce Meltem Erol MD, İstanbul Bağcılar Training and Research Hospital, Clinic of Pediatrics, İstanbul, Turkey Phone: +90 212 440 40 00 E-mail: drmeltemerol@yahoo.com ORCID: orcid.org/0000-0002-7785-6777 Re cei ved: 02.10. 2018 Ac cep ted: 11.02. 2019 1İstanbul Bağcılar Training and Research Hospital, Clinic of Clinical Microbiology, İstanbul, Turkey 2İstanbul Bağcılar Training and Research Hospital, Clinic of Pediatrics, İstanbul, Turkey 3İstanbul Bağcılar Training and Research Hospital, Clinic of Family Medicine, İstanbul, Turkey Ayşe Banu Esen1, Meltem Erol2, Didem Kafadar3, Özlem Bostan Gayret2, Özgül Yiğit2, Tuğçe Damla Dilek2, Kübra Yılmaz2