Miracle-dz/UniFAR-FTUs huggingface dataset:
Stem Cells and Their Niches in Angiogenesis: Vascular Endothelial Stem Cells, Hematopoietic Progenitors and Hematopoietic Effector Cells

10 中文摘要 11 INTRODUCTION 12 REVIEW OF THE LITERATURE 13 1. BLOOD VASCULATURE 13 1.1 EMBRYONIC VASCULAR DEVELOPMENT 13 1.2 PHYSIOLOGICAL ANGIOGENESIS IN ADULTHOOD 15 1.3 TUMOR ANGIOGENESIS 17 2. STEM CELLs/PROGENITORs CONTRIBUTING TO ANGIOGENESIS 17 2.1 ENDOTHELIAL PROGENITOR CELLs (EPC) AND VASCULAR ENDOTHELIAL STEM CELLs (VESC) 18 2.2 HSCs CONTRIBUTE TO ANGIOGENESIS IN A PARACRINE MANNER 22 2.2.1 MYELOID DERIVED SUPPRESSOR CELLs (MDSC) 22 2.2.2 MACROPHAGEs AND DENDRITIC CELLs (DC) 22 2.2. 3 NEUTROPHILs, EOSINOPHILs AND MAST CELLs 23 2.2. 4 PLATELETs 24 3. TRANSFORMING GROWTH FACTOR-­‐β (TGF-­‐β) AND ANGIOGENESIS 24 4. ADULT STEM CELLs AND THEIR NICHEs 26 4.1 THE HEMATOPOIETIC STEM CELL NICHE IN THE BONE MARROW 26 4.1.1 ENDOSTEAL OSTEOBLASTIC NICHE 27 4.1.2 VASCULAR NICHE 28 5. ROLE OF C-­‐KIT IN STEM CELLs 28 5.1 C-KIT AND W LOCI 29 5.2 FUNCTION OF C-KIT 29 6. TARGETING ANGIOGENESIS IN HUMAN DISEASE 30 6.1 ANGIOPREVENTION IN HUMAN CANCER 30 6.2 THERAPEUTIC ANGIOGENESIS IN ISCHEMIC DISEASE 31 AIMS OF THE STUDY 32 MATERIALS AND METHODS 33 1. MATERIALS 33 2. METHODS USED IN THIS STUDY 36 RESULTS AND DISCUSSION 42
French public management reform: an evaluation

Purpose – The purpose of this paper is to measure the dissemination of public management practices in French State administrations and to interpret results in the light of successive reform trends, in order to give an objective evaluation of French public management reform.Design/methodology/approach – The paper is based on a survey on use of management instruments, targeting Heads of Ministry departments (n=298, response rate=80 per cent, use of rigorous sampling techniques). The survey measures actual practices rather than opinions through lists of use of “management instruments”. The method is adapted to evaluate a reform which has mainly been defined in a process of “modernization”. Findings – The findings demonstrate the high level of dissemination of process innovations, even if as observed in many countries, human resource transformation is more challenging than change in quality methods or user's orientation implementation. The survey also points out major disparities between different Ministries a.
A Multi-Domain Spectral Collocation Approach for Solving Lane-Emden Type Equations

Additional available at the end of the Abstract In this work, we explore the application of a novel multi-domain spectral collocation method for solving general non-linear singular initial value differential equations of the Lane-Emden type. The proposed solution approach is a simple iterative approach that does not employ linearisation of the differential equations. Spectral collocation is used to discretise the iterative scheme to form matrix equations that are solved over a sequence of non-overlapping sub-intervals of the domain. Continuity conditions are used to advance the solution across the non-overlapping sub-intervals. Different Lane-Emden equations that have been reported in the literature have been used for numerical experimentation. The results indicate that the method is very effective in solving Lane-Emden type equations. Computational error analysis is presented to demonstrate the fast convergence and high accuracy of the method of solution.
PRESENTATIONS OF INVERSE SEMIGROUPS, THEIR KERNELS AND EXTENSIONS

Abstract Let S be an inverse semigroup and let π:S→T be a surjective homomorphism with kernel K. We show how to obtain a presentation for K from a presentation for S, and vice versa. We then investigate the relationship between the properties of S, K and T, focusing mainly on finiteness conditions. In particular we consider finite presentability, solubility of the word problem, residual finiteness, and the homological finiteness property FPn. Our results extend several classical results from combinatorial group theory concerning group extensions to inverse semigroups. Examples are also provided that highlight the differences with the special case of groups.
Perturbation evolution with a nonminimally coupled scalar field

We recently proposed a simple dilaton-derived quintessence model in which the scalar field was nonminimally coupled to cold dark matter, but not to ``visible'' matter. Such couplings can be attributed to the dilaton in the low energy limit of string theory, beyond the tree level. In this paper we discuss the implications of such a model on structure formation, looking at its impact on matter perturbations and CMB anisotropies. We find that the model only deviates from $\ensuremath{\Lambda}\mathrm{CDM}$ and minimally coupled theories at late times, and is well fitted to current observational data. The signature left by the coupling, when it breaks degeneracy at late times, presents a valuable opportunity to constrain nonminimal couplings given the wealth of new observational data promised in the near future.
Acoustic analysis of German vowels in the Kiel Corpus of Read Speech

There have been a number of acoustic surveys of the vowels of Standard German. These surveys vary with respect to the number of speakers investigated, speaker selection, the quantity and type of material elicited and the vowels surveyed. Jorgensen (1969) uses formant measurements from six male speakers producing word list material. Iivonen (1970) analyses words embedded in carrier phrases as well as in isolation produced by five female and four male subjects. Rausch (1972) analyses four male speakers (one phonetician and three elocutionists) reading a lengthy passage of scientific German. Iivonen (1986) studies one male speaker uttering test words embedded in a carrier phrase. Ramers (1988) analyses four male speakers each reading 63 disyllabic words and 20 sentences. The studies of Standard German are based mainly on data taken from male subjects1 and the selection of vowels surveyed is restricted, with little or no coverage being given to diphthongs, /@/ and the monophthongal exponent of /@r/. This study represents a first spectral survey of the vowel systems of 22 speakers (11 female, 11 male) from part of the PhonDat I corpus collected and labelled in Kiel (Kohler 1992) and is to date the largest survey of its kind on German. All vowels are covered including the diphthongs, /@/ and the monophthongal correlate of /@r/. In addition to providing a summary of the absolute values for the female and male speakers of the corpus we also attempt our own normalization of the vowel systems in order to be able to compare the intergender systemic relationships. As we will show, the results of both our own normalization as well as that described in Nearey (1978)
Some Molecular Studies on Salmonella on Chickens

: The objective of these study to observe the distribution of three such genes, namely, Salmonella enterotoxin (stn) (14, 12, ) (, Salmonella Enteritidis fimbrial (sef) and plasmid encoded fimbrial (pef) genes (15), among different serovars of Salmonella enterica isolated chicken. The work included: Isolation of salmonellae from broiler breeder chicken farms. Phenotypic characterization of Salmonella isolates using: (Morphological, cultural and biochemical identification. Serological identification.) Molecular identification of the isolates using polymerase chain reaction (PCR). Dead birds were collected from broiler chicken farms from 3 distinct governorates, Giza, Monofia and Qaluobia suspected to be salmonellae infected. Specimens for salmonellae isolation included liver, spleen, and intestine that were collected under aseptic condition. A total isolate belonging to S. Typhimurium, S. Enteritidis, S. Blockley, and S. Kentucky serovars were subjected to polymerase chain reaction (PCR) assay for the detection of stn, sef and pef genes using their specific primers and the PCR products were analyzed by 1 per cent agarose gel electrophoresis for the presence of the respective genes. Results: Varying distribution pattern of these genes was observed amongst the isolates. While, stn was found in all the strain we isolated, sef was found only among the S. Enteritidis isolates. The pef gene was found to be absent in some isolates. Conclusion: Findings indicated that the stn gene is widely distributed among Salmonella irrespective of the serovars and source of isolation. However, the sef gene appears to be serovar specific. Since the stn gene is found in all the isolates, it can be a viable target gene to explore the possibility of direct detection of Salmonella from samples from biological sources.
G W calculations including spin-orbit coupling: Application to Hg chalcogenides

We present self-energy calculations for Hg chalcogenides (Hg$X$, $X=\text{S}$, Se, and Te) with inverted band structures using an explicit spin-dependent formulation of the $GW$ approximation. Spin-orbit coupling is fully taken into account in calculating the single-particle Green function $G$ and the screened interaction $W$. We have found, apart from an upward shift of the occupied conductionlike ${\ensuremath{\Gamma}}_{6}$ state by about $0.7$ eV, an enhancement of spin-orbit splitting by about 0.1 eV, in good agreement with experiment. This renormalization originates mainly from spin-orbit induced changes in $G$ rather than $W$, which is affected only little by spin-orbit coupling.
Electrical Treeing Propagation in Nanocomposites and the Role of Nanofillers: Simulationwith the Aid of Cellular Automata

Electrical Treeing Propagation in Nanocomposites and the Role of Nanofillers: Simulationwith the Aid of Cellular Automata In this paper the propagation of electrical treeing in nanodielectrics using the DIMET (Dielectric Inhomogeneity Model for Electrical Treeing) is studied. The DIMET is a model which simulates the growth of electrical treeing based on theory of Cellular Automata. Epoxy/glass nanocomposites are used as samples between a needle-plane electrode arrangement. The diameter of nanofillers is 100 nm. The electric treeing, which starts from the needle electrode, is examined. The treeing growth seems to be stopped by the nanofillers. The latter act as elementary barriers to the treeing propagation.
Research on Engineering Cost Pricing and Control in Design Stage of Construction Project

With the rapid growing of economic development, the engineering industry has shown a good development trend. In the development process of engineering industry, the engineering cost pricing and control in design stage of construction project have become a crucial topic. It have an inestimable impetus, and is of great significance to the work in design stage of construction project how to improve effectiveness of engineering cost pricing and control in design stage of construction project and promote the social benefits of project and the economic benefits. In this paper, the problems related to engineering cost control in design stage of construction project are mainly analyzed, reasonably handled and controlled within the reasonable limits to maximize the project benefits.
Hierarchical simulations of hybrid polymer-solid materials

Complex polymer–solid materials have gained a lot of attention during the last 2–3 decades due to the fundamental physical problems and the broad spectrum of technological applications in which they are involved. Therefore, significant progress concerning the simulations of such hybrid soft–hard nanostructured systems has been made in the last few years. Simulation techniques vary from quantum to microscopic (atomistic) up to mesoscopic (coarse-grained) level. Here we give a short overview of simulation approaches on model polymer–solid interfacial systems for all different levels of description. In addition, we also present a brief outlook concerning the open questions in this field, from the point of view of both physical problems and computational methodologies.
The Study of Judaism as a Contributing Model of an Extended Family in Self Preservation and Human Survival

How social strengths of human beings in case of an available extended family, the Jews could help to understand the probability of self preservation or human survival as a result of group preservation during evolution process because of the availability of modern genealogy and other sufficient scientific studies those support the presence of Jews on planet earth as an ancient but intact social group leading to the assumption that group strengths do possess the potential and probability to be studied as a contributor into self preservation in case of human beings?
Adapting to Pacific Island mangrove responses to sea level rise and climate change

Stresses associated with effects of climate change, including rise in relative mean sea level, present one set of threats to mangroves. Coastal development and ecosystems in the Pacific Islands region are particularly vulnerable to climate change effects. We investigated the capacity of Pacific Island countries and territories to assess mangrove vulnerability to the effects of climate change, and their capacity to adapt to mangrove responses to these forces. Technical and institutional capacity-building priorities include: (1) strengthening management frameworks to conduct site-specific assessment of mangrove vulnerability and incorporate resulting information into land-use plans to prepare for any landward mangrove migration and offsetting anticipated losses; (2) reducing and eliminating stresses on and rehabilitating mangroves, in part, to increase mangrove resilience to climate change effects; and (3) augmenting abilities to establish mangrove baselines, and monitor gradual changes using standardized techniques through a regional network to distinguish local and climate change effects on mangroves. Other priorities are to: (4) assess how mangrove margins have changed over recent decades; (5) determine projections of trends in mean relative sea level and trends in the frequency and elevation of extreme high water events; (6) measure trends in changes in elevations of mangrove surfaces; and (7) incorporate this information into land-use planning processes. Also in (8) some locations require spatial imagery showing topography and locations of mangroves and coastal development. Land-use planners can use information from assessments predicting shoreline responses to projected sea level rise and other climate change effects to reduce risks to coastal development, human safety, and coastal ecosystems. This advanced planning enables coastal managers to minimize social disruption and cost, minimize losses of valued coastal ecosystems, and maximize available options
Home Health Smart TV - Bringing E-Health Closer to Elders

In this paper we present the novel platform for accessing multimedia e-health content adapted for elders. ICT solutions offered on market today are not adapted to elder people. Home Health Smart TV was developed in order to solve this issue. Integration with social network features, like video communication and personalized calendar, solves another concern for elder population social isolation. Elder population is accustomed to TV devices and with this specially designed platform they can access their medical data and communicate with friends, family or medical staff in a simple way that doesn’t require computer literacy.
What Determines Wine Prices: Objective vs. Sensory Characteristics*

Abstract The hedonic technique is applied to wines. In the price equation we include objective characteristics appearing on the label, as well as sensory characteristics and a grade assigned by expert tasters. We have three almost identically structured data sets (two on Bordeaux wines, and one on Burgundy wines). The results are used to make comparisons between two of the most important wine regions in France, and comparisons over time (the two Bordeaux data sets are sampled at different points in time). (JEL Classification: D49.) Another puzzle is the lack of correlation between price and pleasure. Perhaps it is not so surprising that a first-rate example of a little known wine can seem much more memorable than something more famous selling at ten times the price; part of the thrill is the excitement of discovery and the feeling of having beaten the system. What is more extraordinary is the wild price variation at the very top end. Demand bubbles up mysteriously, apparently fuelled by fashion and rumour as much as by intrinsic quality. —Jancis Robinson, Confessions of a Wine Lover, Penguin Books, 1997.
A Rational Approach to Inducing Neuronal Differentiation in Embryonic Stem Cells

ES cells can produce any cell type of a living organism while self-renewing, and have been a favorable tool for cell engineering, transplantation and regenerative medicine (Wobus and Boheler, 2005). There were many issues about the signalling pathways and molecular mechanisms of self-renewal and differentiation in ES cells, however, the discussion has not realized an appropriate goal yet. Thus, it is important to study the signalling pathways, especially in neuronal differentiation, to create a better and novel approach for controlling the differentiation process using mouse model ES cells (Sugimoto et al., 2009; Miyazu et al., 2010). In mouse ES cells, self-renewal and maintenance of pluripotency requires LIF and bone morphogenic proteins (BMPs) (Smith et al., 1988; Williams et al., 1988; Ying et al., 2003). LIF belongs to the cytokine interleukin (IL)-6 family which utilizes the common gp130 receptor for cellular signaling, and LIF signaling is mediated through a low affinity LIF receptor (LIFRβ) which forms a heterodimer with the gp130 upon LIF binding (Hibi et al., 1990; Stahl et al., 1994). The formation of a high affinity trimeric complex composed of LIFRβ, gp130, and LIF leads to the activation of the janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathway and the mitogen-activated protein (MAP) kinase pathway (Burdon et al., 2002; Heinrich et al., 2003; Ernst and Jenkins, 2004; Krinstensen et al., 2005). The binding of LIF to LIFRβ-gp130 results in the rapid activation of JAK which in turn phosphorylates tyrosine residues of LIFRβ and gp130 (Ernst et al., 1996). The phosphorylated tyrosine residues act as binding sites for signaling molecules such as a transcriptional factor STAT3 and a protein tyrosine phosphatase SHP-2 (Heinrich et al., 1998). Recruited STAT3 and SHP-2 are also phosphorylated at tyrosine residues. Phosphorylation of STAT3 promotes the homodimerization through the interaction of the Src homology (SH) 2 domain and the phosphotyrosine domain. The homodimer of STAT3 translocates to the nucleus and functions as a transcriptional factor (Schindler and Darnell, 1995; Darnell, 1997). On the other hand, phosphorylation of SHP-2 generates binding sites for Grb2 and associates with a scaffold protein Grb2-associated binder protein (Gab) 1. The complex subsequently induces the activation of Ras-MAP kinase cascade (Fukada et al., 1996; Van Vactor et al., 1998). Especially, ERKs, which are members of MAP kinase family proteins, are activated by a large number of ligands. The binding of BMP4 to its receptors triggers the phosphorylation of Smad1 and activates the expression of inhibitor of differentiation (Id) gene family. It is considered that the induction of Id expression through Smad1 activation by BMP4 is the critical contribution to the maintenance of pluripotency in
Evaluation of Jamaica's PATH Conditional Cash Transfer Programme how this access benefits you. Your story matters

This paper summarizes the findings of an evaluation of the Programme of Advancement through Health and Education (PATH), a conditional cash transfer programme implemented by the Government of Jamaica. We find that PATH was generally implemented as intended; exhibited better targeting to the poor than other similar social assistance programmes in Jamaica; and had positive and statistically significant impacts on school attendance and number of preventive health care visits for children. We find no evidence, however, that PATH was able to affect longer-term outcomes such as marks, grade progression, or health care status.
BCI to Potentially Enhance Streaming Images to a VR Headset by Predicting Head Rotation

While numerous studies show that brain signals contain information about an individual’s current state that are potentially valuable for smoothing man–machine interfaces, this has not yet lead to the use of brain computer interfaces (BCI) in daily life. One of the main challenges is the common requirement of personal data that is correctly labeled concerning the state of interest in order to train a model, where this trained model is not guaranteed to generalize across time and context. Another challenge is the requirement to wear electrodes on the head. We here propose a BCI that can tackle these issues and may be a promising case for BCI research and application in everyday life. The BCI uses EEG signals to predict head rotation in order to improve images presented in a virtual reality (VR) headset. When presenting a 360° video to a headset, field-of-view approaches only stream the content that is in the current field of view and leave out the rest. When the user rotates the head, other content parts need to be made available soon enough to go unnoticed by the user, which is problematic given the available bandwidth. By predicting head rotation, the content parts adjacent to the currently viewed part could be retrieved in time for display when the rotation actually takes place. We here studied whether head rotations can be predicted on the basis of EEG sensor data and if so, whether application of such predictions could be applied to improve display of streaming images. Eleven participants generated left- and rightward head rotations while head movements were recorded using the headsets motion sensing system and EEG. We trained neural network models to distinguish EEG epochs preceding rightward, leftward, and no rotation. Applying these models to streaming EEG data that was withheld from the training showed that 400 ms before rotation onset, the probability “no rotation” started to decrease and the probabilities of an upcoming right- or leftward rotation started to diverge in the correct direction. In the proposed BCI scenario, users already wear a device on their head allowing for integrated EEG sensors. Moreover, it is possible to acquire accurately labeled training data on the fly, and continuously monitor and improve the model’s performance. The BCI can be harnessed if it will improve imagery and therewith enhance immersive experience.
A Flexible Planar Antenna on Multilayer Rubber Composite for Wearable Devices

This paper presents the design of a flexible antenna using planar dipole with a reflector to achieve optimal radiation efficiency and low specific absorption rate (SAR) when the antenna is placed directly over the skin of body model. The antenna is designed for the 2.45 GHz frequency band. The parametric analysis of the proposed antenna is carried out. The proposed antenna achieves stable onbody performance: |S11| varies from −16.05 dB (on skin) at 2.47 GHz resonant frequency to −16.40 dB (in free space) at 2.44 GHz resonant frequency. It was found that the maximum 1g average SAR value is only 0.23 W/kg for an input power of 100 mW when the antenna is placed directly over the skin of a three-layer body model, and radiation efficiency is 20.5%. The measured results are presented to demonstrate the validity of the proposed antenna.