Miracle-dz/UniFAR-FTUs huggingface dataset:
Depression: A shared risk factor for cardiovascular and Alzheimer disease

Depression has been linked to cardiovascular disease and cognitive impairment, including Alzheimer disease, but the exact nature of the relationship is poorly understood. Although depression seems to progress little after the onset of Alzheimer disease, depression in earlier life increases the risk of dementia and cognitive impairment many years in the future. Depression is also associated with reduced vascular function and is a poorly recognized but significant risk factor for stroke.
Angiotensin II levels in hypertensive and normotensive pregnancies

Summary. We measured circulating angiotension II by radioimmunoassay in women with pregnancy‐induced hypertension (n = 54), and compared these values with those obtained in women with normal pregnancy (n = 18) and in non pregnant women (n = 20). Pregnant women had statistically significantly higher plasma angiotensin II [mean (SD): 41.3 (12.6) pg/ml] than non‐pregnant women [29.2 (11.3) pg/ml; P < 0.004]. Angiotensin II concentrations in women with pregnancy‐ induced hypertension [mean (SD): 31.7 (16.2) pg/ml] were, on average, 25% lower than in normal pregnancy (P < 0.003) and resembled those obtained in non‐pregnant women. The lowest angiotensin II levels were found in women with more severe forms of pregnancy‐induced hypertension, such as proteinuric or superimposed pregnancy‐induced hypertension. Review of the published studies on angiotensin II and our data suggest that the conflict among studies on angiotensin II levels in pregnancy‐induced hypertension is largely due to the heterogeneity of the study populations in the various reports.
Effects of soybean agglutinin on nitrogen metabolism and on characteristics of intestinal tissues and pancreas in rats

Two experiments were conducted to investigate the effects of increasing concentrations of supplemental purified soybean agglutinin on performance, apparent nitrogen digestibility, plasma insulin and cholecystokinine (CCK) levels in rats as well as on the growth of the small intestine and pancreas. In Experiment 1, a 10-day nitrogen balance trial was conducted with 24 male Sprague-Dawley rats (mean BW 85 g) that were randomly allotted to one of four dietary treatments. Rats in each group were provided daily with 7 g of a casein-cornstarch based diet (control) or a diet supplemented with purified soybean agglutinin at 0.4, 0.6 or 0.8 mg/g. Urine and faeces were collected daily and stored at − 20°C until analysis. In Experiment 2, 30 male Sprague-Dawley rats (mean BW 75 g) were divided into five groups for a 20-day growth experiment. Each rat was fed daily 7 g of a casein-cornstarch based diet (control) or a diet supplemented with purified soybean agglutinin at 0.4, 0.8, 1.2 or 2.0 mg/g. All experimental diets were adjusted to contain a similar level of nutrients. Results from the two experiments showed that supplementation of soybean agglutinin below 2.0 mg/g diet had no significant effect on rat performance. However, rats receiving 2.0 mg soybean agglutinin per gram of diet showed a significant reduction in weight gain compared to the control group. Incorporation of soybean agglutinin in the diet reduced apparent nitrogen digestibility and the retention of dietary nitrogen by increasing nitrogen loss from the faeces and urine. In addition, plasma CCK level increased with increasing inclusion of soybean agglutinin in the diet. On the contrary, the plasma insulin level declined as soybean agglutinin level increased. Soybean agglutinin induced a polyamine-dependent hyperplastic and hypertrophic growth of the small intestine and pancreas by increasing the contents of protein, RNA and DNA, though the increase in weight of small intestine was not significant. Furthermore, 1.2 and 2.0 mg soybean agglutinin per gram of diet promoted proliferation of the jejunum mucosa, while the structure of the brush border epithelium of small intestinal had no damaging change and no diarrhoea was observed in any treatment group. Based on these results, supplementation of low doses of soybean agglutinin or soy protein to parenterally-fed animals affected by atrophic small intestine may promote small intestinal growth.
Maintenance therapy with thalidomide improves overall survival after autologous hematopoietic progenitor cell transplantation for multiple myeloma

High‐dose chemotherapy with autologous hematopoietic progenitor cell (HPC) transplantation improves survival for patients with multiple myeloma (MM); however, most patients develop recurrent disease after undergoing transplantation, and new treatment approaches are needed. The objective of this retrospective review of autologous HPC transplantation for patients with MM was to evaluate the impact of conditioning regimens and posttransplantation therapy on survival.
Genes, pathways and checkpoints in lymphocyte development and homeostasis

A plethora of genes involved in murine B and T cell development have been identified, and developmental pathways within the primary lymphoid tissues have been well delineated. The generation of a functional, but non‐self reacting lymphocyte repertoire results from the completion of several checkpoints during lymphocyte development and competition for survival factors in the periphery. Improved knowledge of these developmental checkpoints and homeostatic mechanisms is critical for understanding human immunodeficiency, leukaemia/lymphoma and autoimmunity, which are conditions where checkpoints and homeostasis are likely to be deregulated.
Takeovers: Folklore and Science

Shareholders, who are the most important constituency of the modern corporation because they bear its residual risk, benefit most directly from acquisitions because of the increase in the value of target company shares. Many current criticisms directed at takeover activity are wrong or based on faulty logic. Takeovers protect shareholders from mismanagement of a corporation as they allow alternative management teams to compete for the right to manage the corporation's assets. The takeover market provides a unique, powerful, and impersonal mechanism to accomplish the major restructuring and redeployment of assets continually required by changes in technology and consumer preferences.
Stacked Nb-MoSi/sub 2/-Nb Josephson junctions for AC voltage standards

Superconductor-normal metal-superconductor (SNS) Josephson junctions have proven to be a critical technology for voltage standards. NIST has used SNS junctions for both dc and ac programmable voltage standards. Previous devices have used primarily PdAu as a normal-metal barrier material. In this paper we present measurements of circuits having MoSi/sub 2/ barriers. Stacking enables the junctions to be packed more densely, thus increasing design flexibility and margins for the microwave circuits. In this work, measurements are presented from two- and three-junction stacks for application to ac Josephson voltage standards, which show output voltage and distortion near our best previously published results.
Assessing the Impact of Market Interventions on Firm's Performance

The evaluation of the impact of product-market interventions on the firm's performance has traditionally been based on sales-based measures of the firm's performance ignoring, among other things, the impact on the price of the firm's stock. However, in today's dynamic environment many managers a.re interested in evaluating the impact of product-market interventions on the firm's performance in the stock market. This paper de'JIIOnstrates the usefulness of the time-event methodology from financial economics to assess the impact of prodUct-market interventions on the security prices of a firm's cot! l! lDn stocks. The approach is used to examine the effeets of Procter & Gamble's promotion of the American Dental Association endorsement of Crest on the security prices of Procter & Gamble and that of its major competitor, ColgatePalmolive.
A Priori Estimates and Analytical Construction of Radially Symmetric Solutions in the Gas Dynamics

In this article we derive $\mathscr{C}^{1}$-a priori estimates on the Riemann invariants of the Euler compressible equations in the case of cylindrical or spherical symmetry. These estimates allow us to construct shock waves with a time of existence proportional to the distance to the origin at the initial time.
Multiband joint detection framework for complex Gaussian signals in cognitive radios

An optimal multiband spectrum sensing algorithm is explored which jointly detects the wideband circularly symmetric complex Gaussian primary signal over multiple frequency bands. The spectrum sensing problem is formulated as a set of optimization problems, which maximizes the aggregate opportunistic throughput of a cognitive radio system under some constraints on the interference to the primary user. It is shown through mathematical transformations that these problems can be solved as convex optimization under certain practical constraints.
A Context Sensitive Public Display for Adaptive Multi-User Information Visualization

The use of Public Displays as ubiquitous information visualization means will exploit in the future. These kinds of displays will provide different communities with means for showing opportunistic, information for different users as well as personal information contextualized to the specific moment, situation and location. Current research in this area has identified several problems that are still unsolved concerning simultaneous, multiple user information visualizations. Specific problems raised in this area deal with usability, privacy and personal information management in shared spaces. This paper presents preliminary work that address these open problems and presents ongoing research towards the definition of a model for managing context, content and user interface visualizations for multi-users public displays.
Social impact measurement as an entrepreneurial process.

Third sector organisations are growing in scale and scope, but little is known about how they measure their social value and report their achievements. This paper explores the process of social impact assessment in charities, voluntary organisations, and social enterprises. It looks at why organisations embark on social impact measurement; what guides their decisions about how to measure this impact, and how they use the results. It argues that these decisions are shaped by the objectives of the leadership and power relationships within organisations and, more importantly, with stakeholders outside the organisation. Impact measurement can be seen as a bureaucratic form of regulation or as a form of marketing for organisations with entrepreneurial skills. The lack of consistent approaches, and the range of assumptions that need to be made in any measurement process, provide organisations with ‘room to manoeuvre’ and a source of power to influence others. In this way, the process of measuring impact can been seen as a socially entrepreneurial process – a way to create opportunities and win scarce resources needed to make a social impact.
PENGARUH EFEKTIVITAS KOMITE AUDIT TERHADAP JANGKA WAKTU PELAPORAN KEUANGAN(Studi empiris pada Perusahaan keuangan yang terdaftar di Bursa Efek Indonesia tahun 2012-2013)

This research is a replica of Ika and Ghazali’s (2012). The difference from Ika and Ghazali’s is the subject, this research using financial company, and the sample has never done before. The effectiveness of the audit committee willl be expected to report company financial statements on time according to a predetermied time period. The goal of this research is to find out the relation between the effectiveness of the audit committee and company timelines, and to give descriptive evidence from effectiveness of the audit committe between timelines in finance companies that listed on Indonesia Stock Exchange. This research using financial reporting lead time as dependent variable and as the independent variables are the effectiveness of audit committte, financial conditions, the size of the companies, and the type of auditors. The sample in this research is 93 finance companies that listed on Indonesia Stock Exchange. The metodhs of this research are descriptive statistical analysis, normality test, homogenity test and hypothesis test with ANCOVA. The result shows that 4 of independent variables in this research, only 3 independent variables that has impact to financial reporting lead time. However, only effectiveness of the audit committee that has biggest impact than the others.
Asymmetric kernel method and its application to Fisher&#146;s discriminant

In this paper, we propose the asymmetric kernel method. Furthermore, we apply it to Fisher's discriminant and provide an kernel Fisher's discriminant with variable kernel parameters. We also provide the experimental result of the existing and the new kernel Fisher's discriminants by using several standard datasets and show the advantage of our method
The Croatian national open access journal platform

Until recently, Croatian scientific journals were accessible only in print form and only to a relatively small audience. A national online journals platform was therefore planned to offer publishers a simple tool for building online versions of their journals and to make them open access. The platform, named Hrčak, was launched in 2006, supported by governmental funds. It currently includes 170 open access (OA) journals. Most journals include backfiles from 2006 onwards; the average archived period is 6.3 years. 56.5% of the journals come from the fields of social sciences and humanities. Metadata from the Hrčak platform are regularly harvested by OA repositories. To increase the number of Croatian journals covered by relevant bibliographic and full‐text databases, Hrčak has forged links with Elsevier, Thomson Reuters and EBSCO. So far, the main achievements include assisting publishers in the process of electronic publishing, and improving accessibility to Croatian scientific output.
Adverse prognostic effect of homozygous TET2 mutation on the relapse risk of acute myeloid leukemia in patients of normal karyotype

Mutation in ten-eleven-translocation oncogene family member 2 ( TET2 ) has been extensively investigated in the context of several hematologic malignancies and occurs in 7%–23% of patients with acute myeloid leukemia (AML). [1][1]–[4][2] TET2 acts to demethylate DNA, and TET2 mutations are
Elder abuse: Paucity of data hampers evidence-based injury prevention

B y 2050, 25% of the US population will consist of individuals older than age 65 compared to the 12.5% makeup in 2000. Wolf reported that in 2000, 4% to 6% of older people had been abused. Only a decade later, the US National Elder Mistreatment Study found that 1 in 10 people aged older than 60 has experienced some kind of mistreatment. While it is unclear if this represents an increase in abuse or an increase in reporting, it is certain that elder abuse is common and serious. The Injury Control and Violence Prevention Section of the Eastern Association for the Surgery of Trauma (EAST), the Practice Management Guidelines Section of EAST, the Injury Prevention Committee of the AmericanAssociation for the Surgery of Trauma (AAST), and the Geriatric Trauma Committee of AAST agree that such maltreatment of our elders must stop. The focus of this paper is to educate the trauma community about current literature on elder abuse prevention, encourage prevention initiatives, and direct future research.
Renoprotective Effect of Breviscapine through Suppression of Renal Macrophage Recruitment in Streptozotocin-Induced Diabetic Rats

Background/Aims: Experimental and clinical evidence has consistently demonstrated that renal macrophage infiltration is one of the most important events for the progression of diabetic nephropathy. Breviscapine is a flavonoid extracted from the Chinese herb Erigeron breviscapus. Previously, it was shown that treatment with breviscapine attenuated renal injury in the diabetic rats. The purpose of this study is to investigate whether the renoprotective effect of breviscapine is through suppression of renal macrophage recruitment in diabetic rats. Methods: Diabetes was induced bystreptozotocin injection, and breviscapine was administered orally at a dose of 20 mg/kg/day for 8 weeks. Control rats received vehicle or breviscapine with the same schedule. Results: Breviscapine treatment markedly inhibited both an increase of albuminuria and glomeruli hypertrophy and tubulointerstitial injury without modifying mean arterial blood pressure and creatinine clearance. Levels of malondialdehyde and protein kinase C activities were markedly higher and antioxidant enzyme activities such as superoxide dismutase, catalase as well as glutathione peroxidase were significantly lower in the kidneys of diabetic rats than of the control group, breviscapine administration markedly remitted these changes. ED-1-positive cells and expression of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) in glomeruli and tubulointerstitium were all markedly elevated but were significantly reduced by breviscapine. Western blot analysis noted that the expression of transforming growth factor β1 protein was increased 1.8-fold in the kidney in diabetic rats, breviscapine treatment could reduce increased expression of TGF-β1 protein by 47%. Conclusion: This study describes a novel mechanism by which breviscapine confers a renoprotective effect.
On modules of finite projective dimension

Abstract We address two aspects of finitely generated modules of finite projective dimension over local rings and their connection in between: embeddability and grade of order ideals of minimal generators of syzygies. We provide a solution of the embeddability problem and prove important reductions and special cases of the order ideal conjecture. In particular, we derive that, in any local ring R of mixed characteristic p > 0, where p is a nonzero divisor, if I is an ideal of finite projective dimension over R and p 𝜖 I or p is a nonzero divisor on R/I, then every minimal generator of I is a nonzero divisor. Hence, if P is a prime ideal of finite projective dimension in a local ring R, then every minimal generator of P is a nonzero divisor in R.
A Qualitative Investigation of the Significance of Companion Dogs

Using a qualitative design, the purpose of this study was to examine how people describe their relationship with their dog and what they do that suggest this bond represents a meaningful relationship. Dog owners (N = 27) aged 19 years and older were invited to participate in one of seven focus group discussions. A qualitative content analysis revealed the presence of three themes: (a) the impact of dogs on interpersonal relationships, (b) dogs as subjective beings, and (c) psychological and health benefits of dogs. The second theme reflects the personal agency of dogs and their unique contributions to the human–dog relationship. These themes are discussed in light of the current research in the field. The findings suggest implications for counseling research and practice in improving the health and well-being of dog owners.
Attack Countermeasure Tree ( ACT ) meets with the Split-protocol

In this paper, we present a novel attack tree paradigm called attack countermeasure tree (ACT) comprising an additional attack resistant element known as the Split-protocol. ACT which circumvent the fabrication and way out of a state-space representation and takes keen on account attack, as well as countermesures (in the form of detection and mitigation events). Split-protocol as an attack resistant element enhances the availability of the system during or after a security attack on the system. We compare ACT with or without Split-protocol implantation. The split-protocol concept stemmed from splitting the HTTP/TCP protocol in webserver application. An HTTP/TCP protocol is standard on a webserver can be split into two segments, and each part can be separately run on a different Web server, thus constituting dual servers. These servers communicate across a network by using inter-server messages or delegate messages.In ACT, recognition and alleviation are allowed not just at the leaf node but also at the intermediate nodes,andsimultaneouslythe state-space explosion problem is avoided in its analysis. We study the consequences of incorporating countermeasures in the ACT and Split-protocol using various case studies.
Images of Responsible Consumers: Organizing the Marketing of Sustainability

Purpose – The purpose of this paper is to examine and explain what organizes the marketing of retail sustainability. Design/methodology/approach – Theoretically, this paper takes a marketing-as-practice approach and makes use of practice theory to conceptualize the marketing of sustainability. Methodologically, an ethnographic study of three Swedish retail chains and their marketing work has been conducted. Interviews with management, observations made at the stores of these three retailers and various marketing texts and images produced by these retailers form the material analysed. Findings – This paper illustrates three different ways of marketing and enacting sustainability. It shows that sustainability is framed differently and, indeed, enacted differently in order to fit various ideas about who are the responsible consumers. The argument is that rather than consumer demand, supply pressure or media scandals, the marketing of sustainability is in each of the cases studied configured around a specific notion of the responsible consumer. What sustainability work is marketed, through which devices it is marketed, and how it is framed is guided by an idea of whom the retailers’ responsible consumers are, what their lifestyles are, and what they will be interested in. Images of responsible consumers work as configuring agents around which retailing activities and devices are organized. Originality/value – The paper provides an in-depth analysis of the marketing of sustainability and offers a new explanation about what it is that influences the various approach to sustainable marketing taken by retailers.
Microeukaryote Community Patterns along an O2/H2S Gradient in a Supersulfidic Anoxic Fjord (Framvaren, Norway)

ABSTRACT To resolve the fine-scale architecture of anoxic protistan communities, we conducted a cultivation-independent 18S rRNA survey in the superanoxic Framvaren Fjord in Norway. We generated three clone libraries along the steep O2/H2S gradient, using the multiple-primer approach. Of 1,100 clones analyzed, 753 proved to be high-quality protistan target sequences. These sequences were grouped into 92 phylotypes, which displayed high protistan diversity in the fjord (17 major eukaryotic phyla). Only a few were closely related to known taxa. Several sequences were dissimilar to all previously described sequences and occupied a basal position in the inferred phylogenies, suggesting that the sequences recovered were derived from novel, deeply divergent eukaryotes. We detected sequence clades with evolutionary importance (for example, clades in the euglenozoa) and clades that seem to be specifically adapted to anoxic environments, challenging the hypothesis that the global dispersal of protists is uniform. Moreover, with the detection of clones affiliated with jakobid flagellates, we present evidence that primitive descendants of early eukaryotes are present in this anoxic environment. To estimate sample coverage and phylotype richness, we used parametric and nonparametric statistical methods. The results show that although our data set is one of the largest published inventories, our sample missed a substantial proportion of the protistan diversity. Nevertheless, statistical and phylogenetic analyses of the three libraries revealed the fine-scale architecture of anoxic protistan communities, which may exhibit adaptation to different environmental conditions along the O2/H2S gradient.