Miracle-dz/UniFAR-FTUs huggingface dataset:
Positive selection of a T-cell subpopulation in the thymus in which it develops.

In SWR mice the expression with high-density V beta 17a (high V beta 17a) of the T-cell antigen receptors correlates with the CD4+8- subpopulation of thymocytes. By contrast, in thymocytes of SJL mice the expression of high V beta 17a is observed on the CD4+8- or CD4-8+ subpopulation. However, when the thymocytes from SWR mice have been developed in the SJL or B10 thymus but not in the H-2 compatible DBA/1 thymus, a greater proportion of thymocytes that express high V beta 17a was found to be CD4-8+. By contrast, only a small proportion of KJ23a+ thymocytes from SJL mice that had differentiated in the thymus of SWR or DBA/1 mice was CD4-8+, whereas a high proportion of CD4+8- cells expressed V beta 17a. Further, an intermediate proportion of KJ23a+ thymocytes that had derived from SJL donor mice was present on CD4-8+ thymocytes that had developed in B10.A(4R) thymus. These findings demonstrate that the appearance of a particular subpopulation of thymocytes (CD4-8+ with a beta chain of T-cell antigen receptor identified as V beta 17a) is determined by the histocompatibility complex products that are expressed in the thymic microenvironment in which the T cells develop.
Pitfalls in the diagnosis of reversible cerebral vasoconstriction syndrome and primary angiitis of the central nervous system

A case of a 51‐year‐old woman with reversible cerebral vasoconstriction syndrome (RCVS) without an associative cause is reported. Initially the diagnosis primary angiitis of the central nervous system (PACNS) was considered. Both diagnosis are rare and can mimic each other. Distinction between both can be difficult, but is necessary because of different treatment options. Clinical features and diagnostic assessments to distinguish RCVS from PACNS and the potential pitfalls are discussed.
Risk factors for idiopathic macular holes. The Eye Disease Case-Control Study Group.

PURPOSE A case-control study was conducted to identify possible risk factors for idiopathic macular holes. METHODS One hundred ninety-eight patients with idiopathic macular holes and 1,023 control subjects were identified at five clinical centers. Data were obtained through interviews, clinical examinations, and laboratory analyses of blood specimens. RESULTS One hundred forty-three (72%) affected patients were women. Very few of a broad array of possible risk factors were statistically significant. In a logistic regression model that included both genders, higher plasma fibrinogen levels (P = .0007) and a history of glaucoma (P = .04) were associated with an increased risk of idiopathic macular holes. When the same model was used for women, with estrogen use and parity added as variables, a higher fibrinogen level (P = .002) was positively associated, and estrogen use (P = .04) was negatively associated with risk of macular holes. CONCLUSIONS Of the two factors that stood out as possible risk factors for idiopathic macular holes, the increased risk for women has long been recognized. The association with fibrinogen level was unexpected, and it is unclear whether this is a chance finding or whether higher levels of fibrinogen can increase susceptibility to the forces of vitreous traction, perhaps by compromising the macular blood supply or by some yet unexplained mechanism.
New Insights from Practice: Exploring Online Channel Management Strategies and the Use of Social Media as a Market Research Tool

The concept of online customer experiences, and in particular the role of social media in online customer behaviour, has recently received great interest from academia, business and market researchers alike. Despite the belief that social media, imbedded in a corresponding online channel strategy, can be the key to successfully track and analyse consumer behaviour, most of the research focuses solely on the consumer rather than the companies' strategic viewpoint. This study investigates current online channel management strategies of retail banking services, developing a much-needed typology of such practices. Based upon a thorough and rigorous data analysis process, we propose a typology of online channel strategies. The typology differentiates existing practices into initiators, reformers and consolidators, and discusses the differences between these categories with implications for theory and practice. We highlight the current and future roles of social media market research, and their strategic implications for the industry sector and market research in general, introducing the concept of ‘Strategic Social Intelligence (SSI)’.
Can computers improve patient care by primary health care workers in India?

OBJECTIVE The objective was to test whether a decision support technology for non-physicians can increase health care utilization and quality. DESIGN Before and after measurements were taken from a systematic random sample of patients and staff at randomly assigned intervention and control facilities. SETTING The study took place at primary health facilities in rural Tamil Nadu, India. PARTICIPANTS One thousand two hundred and eighty-six patients and 82 staff were interviewed. INTERVENTION A computer-assisted decision support technology was introduced to assist with patient screening. MAIN OUTCOME MEASURES Outcome measures included new patient visits per month, a Global Patient Assessment of Care Index, and health worker attitude variables. RESULTS There was a difference of difference of 430 new patient visits per month at the intervention sites (P = 0.005), an increase from baseline of 18% at intervention sites compared with a decline of 5% at control sites. The intervention was associated with significant improvements in a Global Patient Assessment of Care Index (mean difference of difference 7.9, P < 0.001). The largest gains were made in patient communication, technical quality, and general satisfaction with care. The attitudes of public health workers toward the new technology and their jobs did not change. CONCLUSIONS Decision support technologies have considerable potential to improve coverage and quality of health care for the poor and where there is no doctor, but the unreceptive attitude of public health workers would need to be overcome. Application of these technologies should take advantage of their popularity with patients and the opportunity to work through the private sector.
Customer satisfaction with services: putting perceived value into the equation

This research investigated the relationship between three elements – core service quality, relational service quality‐ and perceived value – and customer satisfaction and future intentions across four services. The results revealed that core service quality (the promise) and perceived value were the most important drivers of customer satisfaction with relational service quality (the delivery) a significant but less important driver. A direct link between customer satisfaction and future intentions was established. The relative importance of the three drivers of satisfaction varied among services. Specifically, the importance of core service quality and perceived value was reversed depending on the service. A major conclusion was that both perceived value and service quality dimensions should be incorporated into customer satisfaction models to provide a more complete picture of the drivers of satisfaction.
Conflict Management of Water in Tourism Area in Indonesia

This study aim to identify the root causes of conflict management of water in tourism areas in Indonesia. The objects in this research are water tourism stakeholders with the number of 90 respondents which are composed of three different water tourism management in Karanganyar, Central Java, Indonesia, namely Grojogan Sewu, Jumog and Peblengan.The research methodology used in this research ismultiple regression analysis and ANOVA statistical methods. This research adopts a researcher-constructed water tourism conflict questionnaire which elaborates variables such as: level of water usage, life worthy, level of justice, level of responsibility, management capability and tourism area to create a value measuring the extent of water tourism conflict by water tourism stakeholders. The results from Multiple Regression test shows that the conflict is strongly influenced by the level of use of water, different tourism area, and management capabilities. This study is important as it contributes to the literature by providinginsights analysis into conflicts in the management of water resources that occursin the tourist areas in the important tourist water area in Indonesia namely Karanganyar Central Java over regional autonomy that allows in Indonesia to manage the natural resources. There is lack of conflict management of water studies in tourism area, especially in this sample country. DOI: 10.5901/mjss.2016. v7n1s1p416
Influence of Globalization on the Regional Capital Markets and Consequences; Evidence from Warsaw Stock Exchange

The Warsaw Stock Exchange (WSE) is one of the newcomers on the European stock market and at the same time is one of the fast developing stock exchanges in Europe. The development of WSE could be an example of successful development of a national stock exchange into a regional in a relatively short period of time. This article provides analysis of the main trends of development of the WSE through its history to show how globalization influenced regional stock exchanges and to determine key factors that affected its successful development. The WSE is one of the most popular stock exchanges in the Central and Eastern Europe (CEE). Two main lists: Main List and NewConnect are characterized by types of investors, trading turnover and number of companies listed. The article provides quantitative and qualitative analysis of the official reports and analytical papers of key audit and consulting experts that cover both lists of the exchange. The article provides comparison of WSE key performance parameters with major European stock exchanges through 2001 - 2014 and shows those main characteristics of the stock exchange that were mostly influenced by the globalization. Further, the paper shows main consequences of globalization affecting regional stock exchanges. Collected information and results are presented both in tables and in graphical formats.
Semi-Supervised Nonparametric Discriminant Analysis

We extend the Nonparametric Discriminant Analysis (NDA) algorithm to a semi-supervised dimensionality reduction technique, called Semi-supervised Nonparametric Discriminant Analysis (SNDA). SNDA preserves the inherent advantages of NDA, that is, relaxing the Gaussian assumption required for the traditional LDA-based methods. SNDA takes advantage of both the discriminating power provided by the NDA method and the locality-preserving power provided by the manifold learning. Specifically, the labeled data points are used to maximize the separability between different classes and both the labeled and unlabeled data points are used to build a graph incorporating neighborhood information of the data set. Experiments on synthetic as well as real datasets demonstrate the effectiveness of the proposed approach. key words: semi-supervised learning, nonparametric discriminant analysis, manifold learning
Making catheter-related bloodstream infections history : From the slogan to the serious strategy *

less severe clinical bleeding and renal dysfunction. However, in their study, the range in subject ages and diagnoses coupled with only minimal short-term safety data make it impossible to determine even an estimate of the risks in comparison with albumin. With respect to the altered coagulation caused by HES 130/0.4, this study reports equivalence in blood loss; however, I do note that the HES 130/0.4 group received more fresh-frozen plasma. Fresh-frozen plasma exposure was protocol driven based on clinical bleeding and prothrombin times so it is probable that HES 130/0.4 did indeed make a clinically significant, but controlled deterioration in coagulation. There are reports of clinical bleeding after use of HES 130/0.4 over a wide range of uses (3). Clear signals exist in the literature that long lasting, osmotic renal damage occurs in the face of prior renal disease and exposure to colloid substitutes. There is accumulation of the colloid within renal cells with effects that are both short and long term (4). Renal failure does occur with HES 130/0.4 and it does not seem to be 100% predicable based on pretreatment renal function (5, 6). In addition, long lasting and severe pruritus can occur with HES 130/0.4 (7), and there is 41⁄2 times the incidence of potentially life-threatening anaphylactic reactions compared with albumin (3). HES colloids, in general, are relatively contraindicated in the face of sepsis where renal dysfunction and mortality is higher than with other colloids (8). Hanart et al report solid, but preliminary, data that HES 130/0.4 seems equivalent to albumin within the first 24 hours after uncomplicated pediatric cardiac surgery. Now we need an evaluation of long-term efficacy and safety in a multicentered, randomized block design with true blinding at all stages. We are now challenged to take on the question, “Is HES 130/0.4 equivalent in efficacy and safety to albumin for pediatric congenital cardiac surgery? ” before a fiscal decision voids a decision based on quality of care. Brian D. Hanna, MD, PhD Division of Cardiology, Children’s Hospital of Philadelphia Pennsylvania, PA Department of Pediatrics, School of Medicine, University of Pennsylvania Pennsylvania, PA
Critical roles of T‐LAK cell‐originated protein kinase in cytokinesis

We previously reported up‐regulation of T‐LAK cell‐originated protein kinase (TOPK), a novel mitotic kinase, in the great majority of breast cancers. Here we report its critical roles in mitosis, especially in cytokinesis. We found that protein phosphatase 1 alpha (PP1α) inactivation by cyclin‐dependent kinase 1 (CDK1)/cyclin B1 caused enhancement of autophosphorylation of TOPK and resulted in its activation at an early stage of mitosis. Then TOPK interacted with and phosphorylated p97, a member of the AAA+ family of ATPase proteins, through an interaction with p47 protein as an adaptor protein. Interestingly, knockdown of TOPK or p97 in breast cancer cells caused the mitotic failures in the abscission process. This mitotic failure could be rescued by additional exogenous introduction of wild‐type TOPK protein, but not by that of its kinase‐dead form. Our findings suggest that TOPK is indispensable for cancer cell cytokinesis throughout phosphorylation on p97. (Cancer Sci 2009)
Manufacturers' brand advertising and how it influences manufacturers' and retailers' margins

This article describes the effects of manufacturers' brand advertising on the costs, margins and prices of firms in a real-life, 'dual-stage' world where manufacturers sell to retailers who resell to consumers. Unlike 'single-stage' models, which are frequently used by economists, in which manufacturers appear to sell directly to consumers or to deal with them through an inert distribution system, retailers in a dual-stage world neither buy nor sell as perfect competitors. Although in some industry structures advertising will raise prices to consumers, the welfare effects of advertising are far more benign in a dual-stage world. In intensively advertised categories consumers are more disposed to switch stores within brand than brands within store (just the opposite of relationships in categories where brand franchises are weak) causing there to be an inverse association between margins at the two stages. Thus, while intensive advertising will normally raise factory prices it will drive down retailer margins, often to the point that retail prices are below the levels that would be obtained if the industry were only lightly advertised.
AACP Special Taskforce White Paper on Diversifying Our Investment in Human Capital

EXECUTIVE SUMMARY The 2015-2017 American Association of Colleges of Pharmacy (AACP) Special Taskforce on Diversifying our Investment in Human Capital was appointed for a two-year term, due to the rigors and complexities of its charges. This report serves as a white paper for academic pharmacy on diversifying our investment in human capital. The Taskforce developed and recommended a representation statement that was adapted and adopted by the AACP House of Delegates at the 2016 AACP Annual Meeting. In addition, the Taskforce developed a diversity statement for the Association that was adopted by the AACP Board of Directors in 2017. The Taskforce also provides recommendations to AACP and to academic pharmacy in this white paper.
Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Krüppel-like factor

Studies of mouse models of anemia have long provided fundamental insights into red blood cell formation and function. Here we show that the semidominant mouse mutation Nan (“neonatal anemia”) carries a single amino acid change (E339D) within the second zinc finger of the erythroid Krüppel-like factor (EKLF), a critical erythroid regulatory transcription factor. The mutation alters the DNA-binding specificity of EKLF so that it no longer binds promoters of a subset of its DNA targets. Remarkably, even when mutant Nan and wild-type EKLF alleles are expressed at equivalent levels, the mutant form selectively interferes with expression of EKLF target genes whose promoter elements it no longer binds. This interference yields a distorted genetic output and selective protein deficiencies that differ from those seen in EKLF-heterozygous and EKLF-null red blood cells and presents a unique and unexpected mechanism of inherited disease.
Improving runoff prediction through the assimilation of the ASCAT soil moisture product

Abstract. The role and the importance of soil moisture for meteorological, agricultural and hydrological applications is widely known. Remote sensing offers the unique capability to monitor soil moisture over large areas (catchment scale) with, nowadays, a temporal resolution suitable for hydrological purposes. However, the accuracy of the remotely sensed soil moisture estimates has to be carefully checked. The validation of these estimates with in-situ measurements is not straightforward due the well-known problems related to the spatial mismatch and the measurement accuracy. The analysis of the effects deriving from assimilating remotely sensed soil moisture data into hydrological or meteorological models could represent a more valuable method to test their reliability. In particular, the assimilation of satellite-derived soil moisture estimates into rainfall-runoff models at different scales and over different regions represents an important scientific and operational issue. In this study, the soil wetness index (SWI) product derived from the Advanced SCATterometer (ASCAT) sensor onboard of the Metop satellite was tested. The SWI was firstly compared with the soil moisture temporal pattern derived from a continuous rainfall-runoff model (MISDc) to assess its relationship with modeled data. Then, by using a simple data assimilation technique, the linearly rescaled SWI that matches the range of variability of modelled data (denoted as SWI*) was assimilated into MISDc and the model performance on flood estimation was analyzed. Moreover, three synthetic experiments considering errors on rainfall, model parameters and initial soil wetness conditions were carried out. These experiments allowed to further investigate the SWI potential when uncertain conditions take place. The most significant flood events, which occurred in the period 2000–2009 on five subcatchments of the Upper Tiber River in central Italy, ranging in extension between 100 and 650 km2, were used as case studies. Results reveal that the SWI derived from the ASCAT sensor can be conveniently adopted to improve runoff prediction in the study area, mainly if the initial soil wetness conditions are unknown.
SQL/XML and the SQLX Informal Group of Companies

For many years now, the SQL standard has been maintained and enhanced by NCITS Technical Committee H2 on Database in the US and by the ISO/IEC JTC 1/SC32/WG3 Database Languages Working Group internationally. After the publication of SQL:1992, the groups began to publish SQL as a base document (SQL/Foundation) and a number of independent parts. These parts began with SQL/CLI (Call-Level Interface) and SQL/PSM (Persistent Stored Modules) in 1995 and 1996, respectively. Interest in XML has been growing in the last several years among software vendors, user companies of all sizes, and within the standards community. NCITS H2 and SC32 both approved a project for a new part of SQL, part 14, XML-Related Specifications (SQL/XML), in the second half of 2000. After this new project was approved, a small number of companies began to meet in order to explore the technology and develop proposals to begin fleshing out this new part of SQL. This informal group of companies has come to be known as The SQLX Group. In roughly a year’s time, several pieces of what might be termed “infrastructure” have been progressed and are included in the initial working draft of SQL/XML [2].
A 'Research' Database on Infrastructure Economic Performance

The authors present an infrastructure database that was assembled from multiple sources. Its main purposes are: (1) to provide a snapshot of the sector as of the end of 2004; and (2) to facilitate quantitative analytical research on infrastructure. The paper includes definitions, source information, and the most recent data available for 37 performance indicators that proxy access, affordability, and quality of service. Additionally, the database includes a snapshot of 15 reform indicators across infrastructure sectors.
Question 3 : What Causes ASD , and Can Disabling Aspects of ASD Be Prevented or Preempted ?

Since the last Strategic Plan update published in 2013, there have been substantial advances in the understanding of factors that contribute to a diagnosis of autism spectrum disorder. Few would dispute that the causes of ASD are many and include both genetic and environmental factors. There has been an increased appreciation in the last five years of the incredible complexity and interplay of these factors in the development of autism. Indeed, modifications in more than 100 genes are now known to increase the probability of an autism diagnosis (De Rubeis & Buxbaum, 2015; Geschwind & State, 2015) and very reasonable predictions are that 1,000 or more autism risk genes may ultimately be identified. (De Rubeis & Buxbaum, 2015). A plethora of potential environmental challenges have also been associated with autism, although studies in this area lag behind genomics research. There has also been increasing emphasis on events during pregnancy such as influenza infection as potential causes of neurodevelopmental disorders. But, these studies have raised the interesting issue that environmental risks affect different people differently. Nearly 64 percent of women surveyed in the US have experienced an infection during their pregnancies (Collier, Rasmussen, Feldkamp, Honein, & National Birth Defects Prevention, 2009). And maternal infection has been suggested as a risk factor for autism. Yet, obviously, infection during pregnancy does not lead to autism or any other neurodevelopmental disorder in most cases. The current thinking is that additional factors are at play to determine the risk of autism. For example, Mazina et al., (2015) reported that, among mothers who experience infection during pregnancy, the risk of autism depends on whether the mothers and fetuses also have a specific genetic predisposition. This is the so-called genes by environment interaction. More and more modern medical problems are linked to the combination of a particular genome and a particular life history of environmental exposure (the exposome).