Miracle-dz/UniFAR-FTUs huggingface dataset:
Presence of ankyloglossia and breastfeeding in babies born in Lima, Peru: a longitudinal study.

PURPOSE to evaluate the lingual frenulum and breastfeeding in infants from a maternal-perinatal referral center, as well as to monitor infants with ankyloglossia up to six months of age. METHODS a cohort study conducted at the Instituto Nacional Materno Perinatal - Maternidad de Lima in Lima, Peru. The consecutive intentional sample consisted of 304 newborns and their respective mothers, evaluated during December 2017 and January 2018, which were the baseline of the study. A clinical evaluation of the lingual frenulum adapted and the Clinical Evaluation of Breastfeeding Efficacy (CEBE) scale, was performed. RESULTS of the 304 newborns, 15 (4.9%) were considered with altered frenulum, and only 4 (26.7%) presented a low score in CEBE. The mean of the CEBE score was 9.3. (DP=1.35, Min=3, Max=10). Of the follow-up infants, only 2 (13.3%) persisted with breastfeeding difficulties for which frenotomy was indicated. CONCLUSION This study demonstrates the low prevalence of ankyloglossia in infants, as it does not indicate a trend of difficulty or negative interference in breastfeeding.
Late graft loss after intestinal transplantation.

PURPOSE OF REVIEW Despite improvement in short-term outcomes after intestinal transplantation in the last 20 years, long-term rates of graft attrition and patient survival remain unchanged, with worse outcomes compared with other solid organ transplants. This review investigates the multiple causes of late graft loss, including chronic rejection, infection, graft-versus-host disease, posttransplant lymphoproliferative disorder and postsurgical complications. RECENT FINDINGS New insights into immunology of the intestine and evolution of immunosuppression, as well as review of current persistent causes of late graft loss, shed light on findings that may help improve long-term intestinal allograft survival. SUMMARY Although intestinal transplantation remains a life-saving intervention with significant advancements since its inception, further understanding of mechanisms of injury is needed to improve long-term outcomes and prevent late intestinal graft loss.
The developmental hourglass model and recapitulation: An attempt to integrate the two models

Abstract Recapitulation is a hypothetical concept that assumes embryogenesis of an animal parallels its own phylogenetic history, sequentially developing from more ancestral features to more derived ones. This concept predicts that the earliest developmental stage of various animals should represent the most evolutionarily conserved patterns. Recent transcriptome‐based studies, on the other hand, have reported that mid‐embryonic, organogenetic periods show the highest level of conservation (the developmental hourglass model). This, however, does not rule out the possibility that recapitulation would still be detected after the mid‐embryonic period. In accordance with this, recapitulation‐like morphological features are enriched in late developmental stages. Moreover, our recent chromatin accessibility‐based study provided molecular evidence for recapitulation in the mid‐to‐late embryogenesis of vertebrates, as newly evolved gene regulatory elements tended to be activated at late embryonic stages. In this review, we revisit the recapitulation hypothesis, together with recent molecular‐based studies that support the developmental hourglass model. We contend that the recapitulation hypothesis does not entirely contradict the developmental hourglass model and that these two may even coexist in later embryonic stages of vertebrates. Finally, we review possible mechanisms underlying the recapitulation pattern of chromatin accessibility together with the hourglass‐like evolutionary conservation in vertebrate embryogenesis.
Restoring Fertility for Novel Interspecific Hybrids between Kalanchoe garambiensis and K. nyikae Using Colchicine Treatment

Interspecific hybridization is an effective strategy in Kalanchoe breeding programs for the introduction of new traits. Wild species within the Kalanchoe genus are valuable genetic resources for providing new horticulture traits and to improve environmental adaptations. However, reproductive barriers associated with fertilization and hybrid sterility must be overcome to produce fertile hybrid progenies. To approach the breeding objectives for Kalanchoe cut flower cultivars with long stem traits and adaptation to tropical/subtropical regions, a tropical species endemic to Taiwan, Kalanchoe garambiensis Kudo, was used as a parent to cross with other long stem Kalanchoe species. Reciprocal crossing was effective in overcoming interspecific unilateral incompatibility in our crossed pairs. One superior hybrid, ‘103-1’, produced capsules without seeds by selfing and backcrossing with pollens from either parent. Other than the seedless trait, failure of pollen releasing from anther, pollen aggregation and no pollen germination in ‘103-1’ suggested its F1 sterility. Colchicine treatments on apical buds of ‘103-1’ successfully overcame potential meiotic abnormalities by doubling ploidy. For the first time, fertile interspecific hybrids of K. garambiensis and K. nyikae Engler were generated. The fertile hybrid has further produced progeny populations by crossing with K. nyikae or K. blossfeldiana von Poelln, ‘Ida’.
Thermodynamic Study of the Cu-Sr-O System

The Gibbs energies of formation of the inter-oxide compounds in the Cu-Sr-O system have been obtained from solid-state electrochemical measurements in the temperature range 900 to 1300 K. Cells employing yttria-stabilized zirconia or single-crystal calcium fluoride as electrolyte were used in studies of SrCu2O2, Sr2CuO3, SrCuO2, and “Sr3Cu5O8+z. ” The oxygen potential vs stoichiometry dependence was studied, particularly for this last compound, by thermogravimetry at a few selected temperatures in the oxygen partial pressure interval 1 × 101 to 1 × 105 Pa. Based on the results of emf measurement, thermogravimetric study, and X-ray powder diffraction, phase relations in this system were calculated.
Fabrication of Pore-Selective Metal-Nanoparticle-Functionalized Honeycomb Films via the Breath Figure Accompanied by In Situ Reduction

Honeycomb films pore-filled with metal (Au, Ag, and Cu) nanoparticles were successfully prepared by combining the breath figure method and an in situ reduction reaction. First, a polyhedral oligomeric silsesquioxane (POSS)-based star-shaped polymer solution containing metal salt was cast under humid conditions for the formation of honeycomb films pore-filled with metal salt through the breath figure method. The morphology of the honeycomb films was mainly affected by the polymer molecular structure and the metal salt. Interestingly, the promoting effect of the metal salt in the breath figure process was also observed. Then, honeycomb films pore-filled with metal nanoparticles were obtained by in situ reduction of the honeycomb films pore-filled with metal salt using NaBH4. Notably, the metal nanoparticles can be selectively functionalized in the pores or on the surface of the honeycomb films by controlling the concentration of the NaBH4. Metal-nanoparticle-functionalized honeycomb films can prospectively be used in catalysis, flexible electrodes, surface-enhanced Raman spectroscopy (SERS), and wettability patterned surfaces.
Sanitary Ware with Easy Cleaning and/or Antibacterial Properties

Abstract When the sanitary ware (ceramicplus) was launched it was one of the first product in consumer market that offered a surface based on nanotechnology. (ceramicplus) is a ceramic material that is modified by sol-gel methods, the so called wet-chemical nanotechnology thus creating a material of very low surface energy which results in a particularly dirt-repellent and easy-care surface. A further innovative surface is called (activecare). This ceramic glaze contains small quantities of antibacterial silver ions which prevent the build-up of bacteria and ensures hygienic cleanliness. Independent tests by renowned research institutes have verified the properties and long-term effect of (ceramicplus) and (activecare). Because of its water- and dirt-repellent properties (ceramicplus) requires minimum care without influencing the established good properties typical of ceramic materials. The roughness and hardness of ceramicplus is not significantly different from those of conventional ceramic glaze for sanitary ware. Scrubbing tests have proven that only the long-run use of highly abrasive cleaning agents – like scouring powder – may scratch the surface and impair the properties of (ceramicplus) as well as conventional ceramics. Thanks to the easy-care properties of these functionally modified ceramic surfaces such aggressive cleaning agents are not required for cleanliness.
Glucose-6 Phosphate dehydrogenase deficiency contributes to metabolic abnormality and pulmonary hypertension.

We have previously reported that several patients with idiopathic pulmonary hypertension (PH) had different types of G6PD deficiency. However, the role of G6PD in PH is multifactorial because G6PD is involved in controlling oxidative stress, metabolic switch, and red blood cell fragility. To delineate the contribution of G6PD in PH pathogenesis, we utilized a mouse line with decreased expression of G6PD (10% from wild-type level). We confirmed that mice with G6PD deficiency develop spontaneous pulmonary hypertension with pulmonary artery and right heart remodeling. G6PD deficiency resulted in increased free hemoglobin and activation of the p38 pathway, which we recently reported induces the development of PH in the sugen/hypoxia model via endothelial barrier dysfunction. Metabolomics analysis of G6PD deficient mice indicates the switch to alternative metabolic fluxes that feed into the pentose phosphate pathway (PPP), resulting in the upregulation of oxidative stress, fatty acid pathway, and reduction in pyruvate production. Thus, G6PD deficiency did not reduce PPP flux that is important for proliferation but activated collateral pathways at the cost of increased oxidative stress. Indeed, we found upregulation of myo-inositol oxidase, reduction in GSH/GSSG ratio, and increased nitration in the lungs of G6PD deficient mice. Increased oxidative stress also results in the activation of PI3K, ERK1/2, and AMPK that contributes to the proliferation of pulmonary vasculature. Therefore, G6PD deficiency has a multi-modal effect, including hemolysis, metabolic reprogramming, and oxidative stress leading to PH phenotype in mice.
The Prediction of Hydrate Formation Rate in the Presence of Inhibitors

The main objective of this study was to present a novel approach to access more accurate hydrate formation rate predicting models based on the combination of flow-loop experimental data with learning power of artificial neural networks. Therefore, more than 2,300 data of C1, C3, i-C4, and CO2 hydrate formation rate in the presence of two kinetic inhibitors (PVP and L-Tyrosine) and two inhibitor intensifying additives (PPO and PEO) was used. It was found that such models can be used as powerful tools, with total errors less than 2% for the developed models, in predicting hydrate formation rate in these cases.
Effects of the Initial Rock Wettability on Silica-Based Nanofluid-Enhanced Oil Recovery Processes at Reservoir Temperatures

Coreflood experiments were conducted to evaluate the impact of the initial rock wettability on oil recovery during a tertiary oil recovery process using hydrophilic silica-based nanofluids at reservoir temperatures. An adopted scale of reservoir wettabilities (water-, intermediate-, and oil-wet systems) is used for the core plugs, which were prepared by aging processes. The relationships among temperature, initial wettability, and an additional oil recovery nanofluid flooding process were investigated. The results showed that the initial wettability affects oil recovery performance and showed a greater effect at higher temperatures, as represented by the reservoir temperature. An extended postflush nanoflooding was performed to evaluate incremental oil recovery, and this cycle shows great potential for field applications. By evaluating the contact angle and interfacial tension, it was found that wettability alteration plays a more dominant role in the oil displacement mechanism via nano-EOR. These results.
The Influence of Nurses’ Intentions in Dealing with Needlestick Injury (NSI)

This study analyses the influence of intention on Occupational Safety and Health (OSH) performance and behaviour following needlestick injury (NSI) handling procedures. This study utilised a qualitative and quantitative mixed method. Data was obtained through in-depth interviews and observations. The structural equation model (SEM) was used to analyse ex-post facto data. The sample of this study consisted of 289 respondents. They were purposively and randomly selected from the population of all nurses (1,042 people) at Dr. Sardjito Education Hospital in Yogyakarta, with an accuracy level of 5%. Findings show that intention directly affected OSH performance and behaviour following NSI handling procedures. This was indicated by a coefficient of 0.779, z arithmetic value of 10.64 and a p value of 0.000 (<0.05). Intention was proven to have a significant influence on OSH climate and behaviour following NSI handling procedures.
Parasitism and Predation on Sentinel Egg Masses of Three Stink Bug Species (Hemiptera: Pentatomidae) in Native and Exotic Ornamental Landscapes

Abstract This study evaluated parasitism and predation on sentinel egg masses of three stink bug species, the spined soldier bug, Podisus maculiventris (Say), the brown stink bug, Euschistus servus (Say), and the invasive brown marmorated stink bug (BMSB), Halyomorpha halys (Stål), in ornamental landscapes composed of either native or exotic plants. This study also compared the species composition of parasitoids attacking two native stink bug species (P. maculiventris and E. servus) with those attacking the invasive BMSB on the same tree species in the same habitat. Overall, egg parasitism and predation were much higher on the two native stink bug species compared with BMSB, with an average parasitism rate of 20.6% for E. servus, 12.7% for P. maculiventris, and only 4.2% for H. halys and an average predation rate of 8.2% for E. servus,17.7% for P. maculiventris, and 2.3% for H. halys. Egg predation was also significantly higher on P. maculiventris than on E. servus eggs. Eight parasitoid species attacked sentinel stink bug eggs in the ornamental landscaped plots. Trissolcus euschisti (Ashmead) (Hymenoptera: Scelionidae) was the predominant parasitoid for all three stink bug species. There were no significant differences in parasitism and predation rates on any of the stink bug species between native and exotic plots. Therefore, there is no evidence that ornamental landscapes composed of native plants increased parasitism or predation rates of sentinel egg masses of two native stink bug species or the invasive BMSB, compared with those composed entirely of exotic plants.
Pathogenicity and virulence of Staphylococcus aureus

ABSTRACT Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and mortality due to an infectious agent. This pathogen can cause a wide variety of diseases, ranging from moderately severe skin infections to fatal pneumonia and sepsis. Treatment of S. aureus infections is complicated by antibiotic resistance and a working vaccine is not available. There has been ongoing and increasing interest in the extraordinarily high number of toxins and other virulence determinants that S. aureus produces and how they impact disease. In this review, we will give an overview of how S. aureus initiates and maintains infection and discuss the main determinants involved. A more in-depth understanding of the function and contribution of S. aureus virulence determinants to S. aureus infection will enable us to develop anti-virulence strategies to counteract the lack of an anti-S. aureus vaccine and the ever-increasing shortage of working antibiotics against this important pathogen.
Language left behind on social media exposes the emotional and cognitive costs of a romantic breakup

Significance By analyzing language on the social media platform Reddit, we tracked people’s social, cognitive, and emotional lives as they dealt with the breakup of a close intimate relationship. Language markers can detect impending relationship breakups up to 3 mo before they occur, with continued psychological aftereffects lasting 6 mo after the breakup. Because the language shifts are also apparent in subreddits (forums) unrelated to relationships, the research points to the pervasive impact personal upheavals have across people’s social worlds. Comparable cognitive and social effects are apparent among people undergoing divorce or dealing with major life secrets. The analysis of subtle shifts in pronouns, articles, and other almost-invisible words can reveal the psychological effects of life experiences. Using archived social media data, the language signatures of people going through breakups were mapped. Text analyses were conducted on 1,027,541 posts from 6,803 Reddit users who had posted about their breakups. The posts include users’ Reddit history in the 2 y surrounding their breakups across the various domains of their life, not just posts pertaining to their relationship. Language markers of an impending breakup were evident 3 mo before the event, peaking on the week of the breakup and returning to baseline 6 mo later. Signs included an increase in I-words, we-words, and cognitive processing words (characteristic of depression, collective focus, and the meaning-making process, respectively) and drops in analytic thinking (indicating more personal and informal language). The patterns held even when people were posting to groups unrelated to breakups and other relationship topics. People who posted about their breakup for longer time periods were less well-adjusted a year after their breakup compared to short-term posters. The language patterns seen for breakups replicated for users going through divorce (n = 5,144; 1,109,867 posts) or other types of upheavals (n = 51,357; 11,081,882 posts). The cognitive underpinnings of emotional upheavals are discussed using language as a lens.
A phase 1b clinical trial optimizing regulatory T cell depletion in combination with platinum-based chemotherapy in thoracic cancers

ABSTRACT Background: Single-agent cyclophosphamide can deplete regulatory T-cells (Treg). We aimed to determine optimal dosing and scheduling of oral cyclophosphamide, alongside pemetrexed-based chemotherapy, to deplete Treg in mesothelioma or non-small-cell lung cancer patients. Methods: 31 Patients received pemetrexed ± cisplatin or carboplatin on day 1 of a 21-day cycle (maximum 6 cycles). From cycle two, patients received cyclophosphamide, 50 mg/day, with intrapatient escalation to maximum 100/150 mg/day alternately. Immunological changes were examined by flow cytometry. Primary endpoint was Treg proportion of CD4+ T-cells, with doses tailored to target Treg nadir <4%. Results: Reduction in Treg proportion was observed on day 8 of all cycles, and was not augmented by cyclophosphamide. Few patients achieved the <4% Treg target. Treg proliferation reached nadir one week after chemotherapy, and peaked on day 1 of the subsequent cycle. Efficacy parameters were similar to chemotherapy alone. Seventeen percent of patients ceased cyclophosphamide due to toxicity. Conclusions: Specific Treg depletion to the degree seen with single-agent cyclophosphamide was not observed during pemetrexed-based chemotherapy. This study highlights the poor evidence basis for use of cyclophosphamide as an immunotherapeutic in combination with chemotherapy, and the importance of detailed flow cytometry studies. Trial registration: Clinical trial registration: www.anzctr. org.au identifier is ACTRN12609000260224.
3D Scanners in Orthodontics—Current Knowledge and Future Perspectives—A Systematic Review

Background: Nowadays the use of intraoral scanners has become a routine practice in orthodontics. It allows the introduction of many treatment innovations. One should consider to what extent intraoral scanners have influenced the everyday orthodontic practice and in what direction should the further research in this field be conducted. This study is aimed to systematically review and synthesize available controlled trials investigating the accuracy and efficacy of intraoral scanners for orthodontic purpose to provide clinically useful information and to direct further research in this field. Methods: A literature search of free text and MeSH terms was performed by using MedLine (PubMed), Scopus, Web of Science and Embase. The search engines were used to find studies on application of intraoral scanners in orthodontics (from 1950 to 30 September 2020). The following keywords were used: “intraoral scanners AND efficiency AND accuracy AND orthodontics”. Results: The number of potential identified articles was 71, including 61 from PubMed, two from Scopus, three from Web of Science and five from Embase. After removal of duplicates, 67 full-text articles were analyzed for inclusion criteria, 16 of them were selected and finally included in the qualitative synthesis. Conclusions: There are plenty of data available on accuracy and efficacy of different scanners. Scanners of the same generation from different manufacturers have almost identical accuracy. This is the reason why future similar research will not introduce much to the orthodontics. The challenge for the coming years is to find new applications of digital impressions in the orthodontic practice.
Perisaccadic encoding of temporal information in macaque area V4.

The accurate processing of temporal information is of critical importance in everyday life. Yet, psychophysical studies in humans have shown that the perception of time is distorted around saccadic eye movements. The neural correlates of this misperception are still poorly understood. Behavioral and neural evidence suggest that it is tightly linked to other known perisaccadic modulations of visual perception. To further our understanding how temporal processing is affected by saccades, we studied the representations of brief visual time intervals during fixation and saccades in area V4 of two awake macaques. We presented random sequences of vertical bar stimuli and extracted neural responses to double-pulse stimulation at varying inter-stimulus intervals. Our results show that temporal information about very brief intervals of as brief as 20 ms is reliably represented in the multi-unit activity in area V4. Response latencies were not systematically modulated by the saccade. However, a general increase in perisaccadic activity altered the ratio of response amplitudes within stimulus pairs compared to fixation. In line with previous studies showing that the perception of brief time intervals is partly based on response levels, this may be seen as a possible correlate of the perisaccadic misperception of time.