Miracle-dz/UniFAR-FTUs huggingface dataset:
Adrenergic Receptor Activity in the Coronary Arteries of the Unanesthetized Dog

Both α- (vasoconstrictor) and β- (vasodilator) receptor activity was demonstrated in the coronary arteries of the unanesthetized dog independent of adrenergic receptors in the myocardium. In the β-receptor blocked animal, α-adrenergic receptor activity was demonstrated after intravenous and intracoronary injections of epinephrine and norepinephrine by the occurrence of coronary vasoconstriction which could be eliminated by blocking α-adrenergic receptors as well. Coronary vasoconstriction was also seen prior to β-receptor blockade after intravenous phenylephrine and, on occasion, after intracoronary injections of norepinephrine. β-adrenergic receptor activity was demonstrated in several instances after intravenous or intracoronary injections of catecholamines by an initial vasodilatation which could be eliminated by β-adrenergic receptor blockade and which occurred before there was any change in myocardial or systemic hemodynamics. The role of this independent adrenergic receptor activity in the control of the coronary circulation remains to be determined.
Power Distribution Fault Cause Identification With Imbalanced Data Using the Data Mining-Based Fuzzy Classification  $E$-Algorithm

Power distribution systems have been significantly affected by many outage-causing events. Good fault cause identification can help expedite the restoration procedure and improve the system reliability. However, the data imbalance issue in many real-world data sets often degrades the fault cause identification performance. In this paper, the E-algorithm, which is extended from the fuzzy classification algorithm by Ishibuchi to alleviate the effect of imbalanced data constitution, is applied to Duke Energy outage data for distribution fault cause identification. Three major outage causes (tree, animal, and lightning) are used as prototypes. The performance of E-algorithm on real-world imbalanced data is compared with artificial neural network. The results show that the E-algorithm can greatly improve the performance when the data are imbalanced
Olfactory sphere cells are a cell source for γ‐aminobutyric acid‐producing neurons

Olfactory sphere cells (OSCs) are stem cells generated by culturing olfactory mucosa. Adult rat OSCs express oligodendrocyte progenitor cell (OPC) markers and differentiate into mature oligodendrocytes. Although OSCs also express nestin, a marker of neural stem cells (NSCs), it remains unclear whether adult rat OSCs are multipotent and capable of giving rise to neurons as well as oligodendrocytes. Valproic acid (VPA) is a histone deacetylase inhibitor that has the contradictory capacity to induce both differentiation of NSCs and dedifferentiation of OPCs. This study investigates a potential role for VPA in inducing either differentiation or dedifferentiation of adult rat OSCs. Treatment of OSCs with VPA induced hyperacetylation of histones and decreased cell proliferation in the absence of changes in the number of nestin‐positive cells. Furthermore, VPA promoted the genesis of γ‐aminobutyric acid (GABA)‐producing neurons identified by expression of Tuj1/GAD67/GABA while repressing oligodendrocyte production. These findings suggest that OSCs treated with VPA did not exhibit stem cell properties indicative of dedifferentiation but rather switched to a neuronal identity during their terminal differentiation. OSCs were then transplanted into the hippocampus of rats with kainic acid‐induced temporal lobe epilepsy and were systemically given VPA. Although grafted OSCs expressed Tuj1 and GAD67, these cells did not sufficiently inhibit epileptic activity. These results suggest that OSCs are a transplantable cell source for GABA‐producing neurons that can be modulated by VPA. However, further investigation is required to develop them for clinical applications. © 2015 Wiley Periodicals, Inc.
Pricing Objectives and Strategies: A Cross-Country Survey

This chapter reports the results of a descriptive study on pricing objectives and strategies based on a survey among managers in three countries (USA, India and Singapore). The survey instrument was developed using a conceptual framework developed after an analysis of the extant literature on pricing objectives, strategies and factors that infl uence the choice of pricing strategies. Data were collected on fi rms’ utilization of 19 possible pricing strategies, pricing objectives and various pricing determinants. The responses were used to estimate logit models of choice of pricing strategies. The results reveal interesting differences among the three countries as well as the use of different strategies. The implications of this descriptive study for guidance of pricing are discussed.
Does gel affect cytology or comfort in the screening papanicolaou smear?

PURPOSE Current medical training recommends obtaining cervical cytological specimens without the use of lubricating gel. The purpose of this study was to determine whether water-soluble lubricant gel affects cytologic outcomes in the screening Papanicolaou smear and patient comfort during vaginal speculum examination. METHODS The study was a randomized controlled trial performed at David Grant US Air Force Medical Center (Travis Air Force Base, CA). Participants were female patients at least 18 years old presenting for an annual Papanicolaou smear. Each patient, blinded to group assignment, consented to two consecutive Papanicolaou smears. The first Papanicolaou smear was performed without gel in all subjects as part of the "standard of care. " Thirty control patients underwent a second examination with no gel, and 40 other patients had the second examination with gel. All patients rated the discomfort of each Papanicolaou smear on a numerical pain scale. Main outcome measures were cytologic discrepancies on standard glass slide samples and comfort differences regarding the use of gel lubrication. Fisher's exact test was used to interpret the effect of gel on cytology results. Student's t test was performed to compare the discomfort ratings for the second Papanicolaou smear in the GEL vs. the NO GEL groups. RESULTS There was no statistically significant difference between the number of inadequate Papanicolaou smears (P = .50) nor in the discomfort level ratings in the GEL vs. the NO GEL groups (P = .69). CONCLUSION Speculum gel lubrication does not affect cervical cytology during the traditional Papanicolaou smear, nor does it provide significant alteration of patient discomfort.
Implications of abnormal glucose metabolism in patients with coronary artery disease

Abnormal glucose metabolism and type 2 diabetes mellitus (T2DM) are becoming increasingly common. It has been recently confirmed that the period of time prior to the development of diabetes, when patients have impaired glucose tolerance, may also predispose them to increased cardiovascular risk. Therefore prevention and management of T2DM and its antecedents must have high priority when allocating healthcare resources. The present review summarises some information on detection, management and treatment of abnormal glucose metabolism in patients with established coronary artery disease, highlighting the importance of early detection of abnormal glucose metabolism in order to prevent the progression of prediabetes to T2DM and to delay the occurrence of those macrovascular and microvascular complications that impair quality of life and diminish survival.
No beneficial effects of levosimendan in acute porcine endotoxaemia

Background: Levosimendan has been proposed as an attractive alternative to adrenergic agents for the treatment of sepsis‐induced heart failure and haemodynamic derangements. Its use in this setting is, however, still not well investigated. The aim of this study was to test the hypothesis that levosimendan is able to attenuate endotoxin‐induced pulmonary hypertension and improve myocardial function in a porcine model. The secondary aims were to investigate its effect on renal and liver function, and the plasma cytokine response.
Use of ICT for sustainable transportation

The world is experiencing an unfettered growth in terms of development but shrinking the way these developments are leading to the societal, economic and environmental changes and chaos. Sustainability is the answer and needs to be addressed effectively. ICT (Information and Communications Technology) has revolutionized the way things can change. This paper deals with sustainable transportation. Sustainable transport system is a sub topic of a bigger issue “Sustainable Development”. So what does this imply? ICT, can indeed enable the designing of smarter cities that offer a better quality of life for their residents while being more sustainable and cost effective. It is not just the citizens of a country but also the government that can gain benefit from initiatives and meet the objectives faster. This paper digs into the traditional transport systems and the sustainable transport system which we thrive for. Green vehicles/Electric Vehicles/Driverless cars/Hybrid vehicles are the need of the hour. This paper extensively explores the issues and inventions that can lead to sustainable transportation. It further explores the problems associated with them and their solutions. These solutions cover the major aspects of sustainability like meticulous planning, correct usage of ICT and a well drafted and implemented governance framework.
Grading and metastable effects in admittance spectroscopy of CIGS-based solar cells

Cu(In, Ga)Se2-based (CIGS) solar cells have achieved efficiencies up to 20%. Despite these excellent results, the understanding of the underlying mechanisms and the influence of defects on their performance is still incomplete. The determination of the energetic position of the defects and of their density of states is important. Admittance spectroscopy is an adequate technique for this. By varying the external voltage during the measurement, the spatial position where the defect distribution is sensed can be varied. However, the application of external biases can lead to metastable effects in the absorber and therefore to defect relaxation and changes in the doping distribution. Hence, it is important to separate between the effects caused by metastable changes and the change in sensing position of the admittance spectroscopy measurement. This can be achieved by varying the applied voltage during the creation of the metastable state and the measurement itself independently or simultaneously. Admittance spectroscopy under different bias voltage conditions performed on a flexible CIGS-based solar cell are presented and assessed.
Diversity among hospice volunteers: A challenge for the development of a responsive volunteer program

Voluntary organizations such as hospices are increasingly being called upon to substitute for state health and social welfare delivery at a time when volunteer contributions are threatened because of organizational and demographic changes. These changes include: the adoption by the nonprofit sector of market strategies in response to health and social welfare reforms, increases in the size and complexity of hospices, increasing professionalization of staff, and the move of women away from voluntary work in the health and welfare services to paid employment. With these changes, hospices must be knowledgeable about their volunteer workforce and resourceful if they are to continue to attract and retain volunteers. A survey of volunteers conducted at the Mary Potter Hospice, Wellington, New Zealand, examined differences in volunteers’ characteristics, motivations for joining hospice, and factors affecting work satisfaction according to age, gender, and the length of time volunteers had worked. Those findings of particular relevance to program development were: (1) the tendency for the recently recruited volunteers to be in paid employment; (2) the mixed motivations of the younger volunteers, reflecting both altruistic and personal gain needs; and (3) the rewards commonly identified by volunteers, such as feeling their work is of value, being accepted by hospice staff, and feeling like important team members. Practical outcomes of the study are described.
Organizational logic to prioritize between the elements of triple bottom line

Purpose The purpose of this paper is to assess both private and public organizations in order to compare the similarities and differences between the organizational priority logic of TBL elements. The research objective is, therefore, to describe the organizational logic, so as to prioritize between economic, social and environmental elements of the triple bottom line (TBL). The approach is also to describe the common denominators and differentiators between private and public organizations. Design/methodology/approach Based on judgmental sampling and in-depth interviews of executives at private and public hospitals in Spain. Data were collected from the directors of communication of private hospitals, and from the executive in charge of corporate social responsibility of public hospitals. Findings The organizational logic for prioritizing the elements of TBL differs between private and public hospitals. The economic element of TBL is crucial to survival for private hospitals. Compliance with the legal requirements and certifications of the environmental element is the major concern for public hospitals. Private and public hospitals would both pay considerably greater attention to the social element of TBL, if there were no judicial and economic restrictions. Research limitations/implications This study differs from previous ones in terms of exploring the interfaces and relationships between TBL elements, which focus on the organizational logic to prioritize between the elements of TBL. There are both common denominators and differentiators between private and public hospitals, when it comes to the priority logic of TBL elements. Practical implications The priority logic of determining the most important TBL element it is mainly about satisfying organizational needs and societal demands. Determining the second most important TBL element is mostly about organizational preferences and what it wants to achieve. Determining the least important TBL element it is about the organizational mindset for and with respect to the future. Originality/value This study contributes to determining the appropriate organizational priority logic of the TBL elements, as well as common denominators and differentiators between private and public organizations. It also contributes to explaining the organizational reasoning as to why one TBL element may be prioritized over another, an issue which has not been addressed in existing theory and previous studies.
TYPE Ia SUPERNOVA RATE MEASUREMENTS TO REDSHIFT 2.5 FROM CANDELS: SEARCHING FOR PROMPT EXPLOSIONS IN THE EARLY UNIVERSE

The Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS) was a multi-cycle treasury program on the Hubble Space Telescope (HST) that surveyed a total area of ∼0.25 deg2 with ∼900 HST orbits spread across five fields over three years. Within these survey images we discovered 65 supernovae (SNe) of all types, out to z ∼ 2.5. We classify ∼24 of these as Type Ia SNe (SNe Ia) based on host galaxy redshifts and SN photometry (supplemented by grism spectroscopy of six SNe). Here we present a measurement of the volumetric SN Ia rate as a function of redshift, reaching for the first time beyond z = 2 and putting new constraints on SN Ia progenitor models. Our highest redshift bin includes detections of SNe that exploded when the universe was only ∼3 Gyr old and near the peak of the cosmic star formation history. This gives the CANDELS high redshift sample unique leverage for evaluating the fraction of SNe Ia that explode promptly after formation (<500 Myr). Combining the CANDELS rates with all available SN Ia rate measurements in the literature we find that this prompt SN Ia fraction is , consistent with a delay time distribution that follows a simple t−1 power law for all times t > 40 Myr. However, mild tension is apparent between ground-based low-z surveys and space-based high-z surveys. In both CANDELS and the sister HST program CLASH (Cluster Lensing And Supernova Survey with Hubble), we find a low rate of SNe Ia at z > 1. This could be a hint that prompt progenitors are in fact relatively rare, accounting for only 20% of all SN Ia explosions—though further analysis and larger samples will be needed to examine that suggestion.
The Shorter Leibniz Texts: A Collection of New Translations

Acknowledgements Bibliography Introduction A note on the translations Part I. Metaphysics A. Creation B. Truth and Substance Part II: Mind, Body and Soul A. Souls and their nature B. The relationship between soul and body C. The fate of souls Part III. Free Will and Necessity A. The nature of free will B. Contingency and necessity Part IV: Science A. Matter and body B. The laws of nature C. Biology Part V. Law and Ethics A. Law B. Virtue C. Pleasure and happiness VI. Theology A. The existence of God B. Optimism and meliorism C. Sin and evil.
Savé Valley Conservancy: A Large-Scale African Experiment in Cooperative Wildlife Management

The Savé Valley Conservancy (SVC) is a large (3442km) cooperatively managed wildlife area, comprising multiple properties held by private ranchers, local councils, government and one community. The conservancy is located in the semi-arid South East Lowveld of Zimbabwe, occurring at an elevation of 480–620m, with deciduous woodland savanna, low and variable rainfall (474–540mm per annum) and poor-quality soils. The conservancy is bordered primarily by high-density communal land (of between 11 and 82 people per km), with some commercial agriculture to the south and east (Pole, 2006).
Learning Phenomena of MMORPG PLAYERS: A PROPOSED RESEARCH MODEL

This research in progress aims to contributing to the already existing knowledge on the phenomena of learning existing in the massively multi-players online role-playing games (MMORPG). The objective is to be able to identify social skills (personality) and professional skills (managerial skills) which the players can develop by playing in MMORPG. A better knowledge of the effects of this technology on the players would allow to know better the consequences on the real life of the players as the recruitment by online games. So, by basing us on learning theories then on a previous qualitative study led with players and old players, we propose a model of research illustrating the influence of the practice of the MMORPG on the player.
Caveolin‐1 influences P2X7 receptor expression and localization in mouse lung alveolar epithelial cells

The P2X7 receptor has recently been described as a marker for lung alveolar epithelial type I cells. Here, we demonstrate both the expression of P2X7 protein and its partition into lipid rafts in the mouse lung alveolar epithelial cell line E10. A significant degree of colocalization was observed between P2X7 and the raft marker protein Caveolin‐1; also, P2X7 protein was associated with caveolae. A marked reduction in P2X7 immunoreactivity was observed in lung sections prepared from Caveolin‐1‐knockout mice, indicating that Caveolin‐1 expression was required for full expression of P2X7 protein. Indeed, suppression of Caveolin‐1 protein expression in E10 cells using short hairpin RNAs resulted in a large reduction in P2X7 protein expression. Our data demonstrate a potential interaction between P2X7 protein and Caveolin‐1 in lipid rafts, and provide a basis for further functional and biochemical studies to probe the physiologic significance of this interaction.
Strategic Customer Relationship Management Practices: Employees’ Perception of its Influence on Competitive Advantage and Organizational Performance in the Nigerian Banking Sector

The study aimed at examining employees’ perception of the influence of strategic customer relationship management practices (SCRMPs) on competitive advantage (CA) and organizational performance (OP). The SCRMPs was captured through customer focus, knowledge management, CRM organizations and technology based CRM; CA was measured through customer satisfaction and customer retention; while profitability and market share were used to measure organizational performance. A descriptive survey design was adopted; data were gathered through a self-structured questionnaire administered to 240 staff of commercial banks in Ibadan, Oyo state out of which the response of 200 staff were considered useful for the study.Data gathered was coded and entered into the Statistical Package Software for Social Science (SPSS) version 20 and the method of linear regression was used to test the hypotheses formulated. The findings of the study indicate that, there is a strong influence of SCRMPs on CA and OP with r value of 0.739 and 0.921 respectively. The relationship between SCRMPs and OP is stronger (0.921) compared to that of CA (0.737). Also, the result of the analysis shows that there is a strong relationship between CA and OP of commercial banks in Oyo state with r value of 0.797. Based on results of the analysis, organizations should not relent in the activities of managing their relationship with customers through appropriate SCRM practices for better CA and better OP.
[Clinical characteristics of 33 patients with adrenal incidentaloma].

UNLABELLED Incidentally diagnosed, clinically asymptomatic adrenal masses (incidentaloma) have become more and more common problem in everyday clinical practice. The prevalence of such tumors is 2.3% in autopsy series and 0.5-2% in computed tomography series. The aim of the study was a clinical analysis of patients with adrenal incidentaloma, hospitalized in the Department of Internal and Metabolic Diseases of the Medical University of Silesia. MATERIAL AND METHODS 33 patients, including 25 females (75.7%) and 8 males (24.3%), were investigated. The mean age was 59.0 +/- 10.7 year (31-80) and the mean body mass index (BMI) was 29.6 +/- 5.9 kg/m2 (19.4-47). RESULTS 16 patients (48.5%) were obese and 10 more patients (30.3%) were overweight. Hypertension was diagnosed in 25 patients (75.8%), diabetes or impaired glucose tolerance in 9 patients (27.3%) and hyperlipidemia in 20 patients (60.6%). Endocrine tests revealed: disturbed cortisol rhythm in 1 patient, uncertain result of the overnight dexamethasone suppression test in 4 patients, elevated urinary 17-hydroxycorticosteroids excretion in 7 patients, elevated urinary 17-ketosteroids excretion in 2 patients and increased urinary excretion ofvanillylmandelic acid in 2 patients. The tumor was located in the right adrenal gland in 13 patients (39.4%) and in the left adrenal gland in 16 patients (48.5%). 4 patients (12.1%) demonstrated bilateral adrenal masses. At least one of the tumor sizes was greater than 40 mm in 3 patients (9.1%). CONCLUSION Clinically asymptomatic adrenal tumors occurred more frequently in overweight or obese women, between 51-70 years old, with lipid disorders and hypertension.
ETS1 encoding a transcription factor involved in B-cell differentiation is recurrently deleted and down-regulated in classical Hodgkin's lymphoma

The neoplastic B-cell derived Hodgkin and Reed-Sternberg cells (HRS) in classical Hodgkin's lymphoma (cHL) undergo a substantial loss of B-cell identity. It has been suggested that epigenetic mechanisms such as DNA methylation are involved in this cHL-associated reprogramming. [1][1] In a recent