Miracle-dz/UniFAR-FTUs huggingface dataset:
Performance of family health teams for tackling chronic diseases in a state of the Amazon

The most common cause of death worldwide is noncommunicable diseases. A cross-sectional study was conducted to evaluate the adequacy of the work process among family health teams and compare differences in regional adequacy in the state of Tocantins, in the Amazonian Region, Brazil. Categorical principal components analysis was used, and scores of each principal component extracted in the analysis were compared among health regions in Tocantins. A post hoc analysis was performed to compare the heath region pairs. The adequacy of family health teams’ work process was evaluated with respect to the Strategic Action Plan to Tackle NCDs. The results showed that the family health teams performed actions according to the Strategic Action Plan to Tackle NCDs. However, overall, the adequacy percentages of these actions according to the axes of the Plan are very uneven in Tocantins, with large variations among health regions. The family health teams in the Bico do Papagaio (Region 1), Médio Norte Araguaia (Region 2), Cantão (Region 4) and Capim Dourado (Region 5) regions have adequacy percentages ≥ 50% with the Strategic Action Plan to Tackle NCDs, whereas all other regions have percentages <50%. Health teams perform surveillance actions, health promotion, and comprehensive care for NCDs in accordance with the guidelines of the Strategic Action Plan to Tackle NCDs. The challenge of NCDs in primary care requires a care model that is tailored to users’ needs and has the power to reduce premature mortality and its determinants.
Self-Assembled Nanocarriers Based on Modified Chitosan for Biomedical Applications: Preparation and Characterization

Protein-polysaccharide systems are of increasing interest as their combined attributes allow for fulfilling a broad range of applications in biomedical and pharmaceutical fields. In this study, the preparation of nanogels based on maleic anhydride chitosan derivatives (MAC) and bovine serum albumin (BSA) was achieved through a self-assembly process performed in aqueous phase. A series of experiments performed by varying the concentrations of MAC and BSA were conducted to find an appropriate mixing ratio for the polymer solutions leading to thermodynamically stable nanogels with the ability to encapsulate active compounds. The influence of temperature on the formation of nanogels was also studied. The consequent conformational changes were monitored using ultraviolet-visible (UV-VIS) spectrophotometry. The spectrophotometric investigations combined with diffraction light scattering (DLS) technique and zeta potential measurement results were correlated to determine the interaction mechanism and assess the self-assembling processes during nanogel formation. It was found that the hydrodynamic diameter (Dh) of the nanoparticles increased slightly at acidic pH, and the protonation of ionizable amino groups with the pH was confirmed by the zeta potential measurements. MAC/BSA nanogels also exhibited antimicrobial properties after being loaded with amoxicillin (Amox), which is an antibiotic used for the treatment of various infections. The experimental data resulting from this study provide theoretical guidance for the design and development of attractive nanocarriers for a large variety of biomedical applications.
Myths about Intimate Partner Violence and Moral Disengagement: An Analysis of Sociocultural Dimensions Sustaining Violence against Women

Intimate partner violence (IPV) is a public health issue worldwide and a serious violation of human rights. Recognizing IPV as a form of violence is essential for both victims who need help and offenders who can join treatment programs. Furthermore, only a society able to identify violence can effectively deal with IPV. The present study is aimed at investigating the role of sociocultural dimensions (i.e., ambivalent sexism toward women, ambivalence toward men, and lay theories about gender differences) in sustaining myths about IPV and moral disengagement. The participants were 359 university students (76.5% female). The results show that hostile sexism toward women plays a key role in sustaining both myths and moral disengagement. Moreover, benevolence toward men and biological lay gender theories (i.e., “naïve” theories assuming that sex differences are a product of biology and genetics) significantly affected the endorsement of IPV myths. The implications are discussed.
Learning from Routing Information for Detecting Routing Misbehavior in Ad Hoc Networks

Owing to ad hoc wireless networks’ properties, the implementation of complex security systems with higher computing resources seems troublesome in most situations. Therefore, the usage of anomaly or intrusion detection systems has attracted considerable attention. The detection systems are implemented either as host-based, run by each node; or as cluster/network-based, run by cluster head. These two implementations exhibit benefits and drawbacks, such as when cluster-based is used alone, it faces maintaining protection when nodes delay to elect or replace a cluster head. Despite different heuristic approaches that have been proposed, there is still room for improvement. This work proposes a detection system that can run either as host- or as cluster-based to detect routing misbehavior attacks. The detection runs on a dataset built using the proposed routing-information-sharing algorithms. The detection system learns from shared routing information and uses supervised learning, when previous network status or an exploratory network is available, to train the model, or it uses unsupervised learning. The testbed is extended to evaluate the effects of mobility and network size. The simulation results show promising performance even against limiting factors.
Impact of different regenerative techniques and materials on the healing outcome of endodontic surgery: a systematic review and meta-analysis.

BACKGROUND Regenerative techniques are increasingly applied in endodontic surgery, but different materials used in regenerative techniques may have varying impacts on wound healing. OBJECTIVES This study evaluated the effects of different regenerative techniques and materials on the outcome of endodontic surgery. PARTICIPANTS patients with persistent periapical lesions, treated with root-end surgery. CONTROL endodontic surgery without the use of regenerative techniques/materials. INTERVENTION endodontic surgery with the use of regenerative techniques/materials. OUTCOME combined clinical and radiographic results. METHODS PubMed, Web of Science, Embase, SinoMed, and the CENTRAL Cochrane were searched up to July 10th , 2020, followed by a manual search. Detailed eligibility criteria were applied. Cochrane's risk-of-bias tool 2.0 was used to assess the risk of bias of the eligible studies. Meta-analysis was conducted using RevMan software. Subgroup analyses were performed based on the regenerative materials used in endodontic surgery. RESULTS Eleven eligible randomised controlled trials (RCTs) were included in the meta-analysis: two had a low risk of overall bias, and nine had some concerns of overall bias. Generally, the use of regenerative techniques significantly improved the outcome of endodontic surgery (risk ratio [RR]: 0.42; 95% confidence interval [CI], 0.26-0.68; p < 0.001). On subgroup analysis, the use of expanded polytetrafluoroethylene (e-PTFE) membranes alone had no added benefits (RR: 2.00; 95% CI, 0.22-18.33; p = 0.54). The application of collagen membranes or autologous platelet concentrates (APCs) alone was associated with a trend for better outcomes (RR: 0.51; 95% CI, 0.20-1.25; p = 0.14) (RR: 0.55; 95% CI, 0.18-1.71; p = 0.30). The combined use of collagen membranes and bovine-derived hydroxyapatite significantly improved the outcome (RR: 0.35; 95% CI, 0.17-0.75; p = 0.007). DISCUSSION This systematic review evaluated the effects of collagen membranes, e-PTFE membranes, APCs, and bone grafting materials, providing detailed information about the risks and benefits of using each regenerative technique/material or its combination in endodontic surgery. CONCLUSIONS Regenerative techniques improve periapical lesion healing after endodontic surgery. The combined use of collagen membranes and bovine-derived hydroxyapatite may be beneficial as an adjunct to endodontic surgery. In contrast, the positive efficacy of e-PTFE membranes or APCs alone remains doubtful.
Heart failure epidemiology and treatment in primary care: a retrospective cross‐sectional study

Heart failure is one of the leading causes of morbidity and mortality worldwide, but little is known on heart failure epidemiology and treatment in primary care. This study described patients with heart failure treated by general practitioners, with focus on drug prescriptions and especially on the only specific treatment for heart failure with reduced ejection fraction, namely sacubitril/valsartan.
One step closer to understanding the ecology of Cameraria ohridella (Lepidoptera: Gracillariidae): The effects of light conditions

Horse chestnut leaf miner (Cameraria ohridella) has achieved ecological success by colonizing the entire European range of its primary host, horse chestnut (Aesculus hippocastanum). This insect has attracted the attention of scientists, but its ecology is poorly understood. Here, we investigated the effects of varying degrees of light availability on the leaf morphology of horse chestnut saplings and the performance of C. ohridella. A pot experiment under greenhouse conditions was performed in which the photosynthetic photon flux density (PPFD) was reduced from full light by 50% (high light - HL) or 80% (low light - LL). Insect performance parameters were quantified (i.e., pupal mass, efficiency of conversion of utilised leaf tissue (ECU) and potential fecundity). Compared with HL leaflets those from LL were characterised by higher contents of nitrogen and water but lower total phenolics. The oxidative capacity of phenolics (at pH ≈ 10, common in the lepidopteran gut) was low and did not differ in the two treatments. Compared with those collected from HL leaves, the mines of those collected from leaves of plants grown under LL conditions were larger in area but the leaf mass utilized by larvae was similar. Pupae were heavier in LL than in HL conditions, and ECU was higher in LL. The potential fecundity of females was not sensitive for experimental treatment. We conclude that (1) reduced light had a strong beneficial effect on the performance of C. ohridella and (2) phenolics in A. hippocastanum leaf tissues are a poor defence against this herbivore.
Role of fluorescent pseudomonas associated with root nodules of mungbean in the induction of nodulation by the rhizobia in mungbean.

Fluorescent Pseudomonas has been reported to associate with root nodules of a number of plants and play role in plant disease suppression and increased plant growth. However their role in nodule formation is still unclear. In a gnotobiotic experiment, combined effect of two isolates each of fluorescent Pseudomonas (NAFP-19 and NAFP-32) and rhizobia (Rhizobium vignae (NFB-103) and R. vignae (NFB-109) on nodules of mungbean was evaluated. The results showed an increase in the number of nodule primordia, mature nodules and the concentration of nitrogen and phosphorus in mungbean plants. In screen house experiment, garden soil which was naturally infested with root rotting fungi and rhizobia was used. Dual application of Pseudomonas and rhizobia in the garden soil produced greater number of nodules per plant and higher nitrogen fixation than when rhizobia were used alone. Dual application of bacteria also suppressed root rotting fungi. The results showed that nodule associated fluorescent Pseudomonas played a role in plant-rhizobia symbiosis.
Eco-evo-devo implications and archaeobiological perspectives of trait covariance in fruits of wild and domesticated grapevines

The phenotypic changes that occurred during the domestication and diversification of grapevine are well known, particularly changes in seed morphology, but the functional causes and consequences behind these variations are poorly understood. Wild and domesticate grapes differ, among others, in the form of their pips: wild grapes produce roundish pips with short stalks and cultivated varieties have more elongated pips with longer stalks. Such variations of form are of first importance for archaeobotany since the pip form is, most often, the only remaining information in archaeological settings. This study aims to enlighten archaeobotanical record and grapevine pip development by better understanding how size and shape (co)variates between pip and berry in both wild and domesticated Vitis vinifera. The covariation of berry size, number of seeds per berry (“piposity”), pip size and pip shape were explored on 49 grapevine accessions sampled among Euro-Mediterranean traditional cultivars and wild grapevines. We show that for wild grapevine, the higher the piposity, the bigger the berry and the more elongated the pip. For both wild and domesticated grapevine, the longer is the pip, the more it has a “domesticated” shape. Consequences for archaeobotanical studies are tested and discussed, and these covariations allowed the inference of berry dimensions from archaeological pips from a Southern France Roman site. This systematic exploration sheds light on new aspects of pip-berry relationship, in both size and shape, on grapevine eco-evo-devo changes during domestication, and invites to explore further the functional ecology of grapevine pip and berry and notably the impact of cultivation practices and human selection on grapevine morphology.
Tamoxifen Delivery System Based on PEGylated Magnetic MCM-41 Silica

Magnetic iron oxide containing MCM-41 silica (MM) with ~300 nm particle size was developed. The MM material before or after template removal was modified with NH2- or COOH-groups and then grafted with PEG chains. The anticancer drug tamoxifen was loaded into the organic groups’ modified and PEGylated nanoparticles by an incipient wetness impregnation procedure. The amount of loaded drug and the release properties depend on whether modification of the nanoparticles was performed before or after the template removal step. The parent and drug-loaded samples were characterized by XRD, N2 physisorption, thermal gravimetric analysis, and ATR FT-IR spectroscopy. ATR FT-IR spectroscopic data and density functional theory (DFT) calculations supported the interaction between the mesoporous silica surface and tamoxifen molecules and pointed out that the drug molecule interacts more strongly with the silicate surface terminated by silanol groups than with the surface modified with carboxyl groups. A sustained tamoxifen release profile was obtained by an in vitro experiment at pH = 7.0 for the PEGylated formulation modified by COOH groups after the template removal. Free drug and formulated tamoxifen samples were further investigated for antiproliferative activity against MCF-7 cells.
Development and Internal Validation of a Prediction Model to Risk Stratify Children with Suspected Community-Acquired Pneumonia.

BACKGROUND Although community-acquired pneumonia (CAP) is one of the most common infections in children, no tools exist to risk stratify children with suspected CAP. We developed and validated a prediction model to risk stratify and inform hospitalization decisions in children with suspected CAP. METHODS We performed a prospective cohort study of children age 3 months to 18 years with suspected CAP in a pediatric emergency department (ED). Primary outcome was disease severity, defined as mild (discharge home or hospitalization for <24 hours with no oxygen or intravenous (IV) fluids), moderate (hospitalization <24 hours with oxygen or IV fluids, or hospitalization >24 hours), or severe (intensive care unit (ICU) stay for >24 hours, septic shock, vasoactive agents, positive-pressure ventilation, chest drainage, extracorporeal membrane oxygenation, or death). Ordinal logistic regression and bootstrapped backwards selection were used to derive and internally validate our model. RESULTS Of 1128 children, 371 (32.9%) developed moderate disease and 48 (4.3%) severe disease. Severity models demonstrated excellent discrimination (optimism-corrected c-indices of 0.81) and outstanding calibration. Severity predictors in the final model included respiratory rate, systolic blood pressure, oxygenation, retractions, capillary refill, atelectasis or pneumonia on chest radiograph, and pleural effusion. CONCLUSIONS We derived and internally validated a score that accurately predicts disease severity in children with suspected CAP. Once externally validated, this score has potential to facilitate management decisions by providing individualized risk estimates that can be used in conjunction with clinical judgment to improve the care of children with suspected CAP.
Knowledge, Attitude, and Barriers to Telerehabilitation-Based Physical Therapy Practice in Saudi Arabia

(1) Telerehabilitation (TR) is a part of telemedicine involved in providing rehabilitation services to people in remote locations. TR in physical therapy in the kingdom of Saudi Arabia is still in its infancy and its implementation may pose different challenges in the physical therapy settings. The purpose of this nation-wide survey is to explore physiotherapists (PTs) knowledge, attitudes, and barriers towards implementation of TR in physical therapy settings; (2) Methods: A 14 item questionnaire was developed and mailed to PTs working in hospitals and rehabilitation centers across 13 provinces in Saudi Arabia; (3) Results: 347 PTs responded. Results are as follows: 58.8% (n = 204) of PTs reported that they had sufficient knowledge about TR. About31.7% (n = 110) of PTs reported that their hospital and rehabilitation center had installed TR, yet only 19.9% (n = 69) utilized the TR facility. Image-based TR was more frequently used (n = 33) as compared to sensor-based TR (n = 29) and virtual reality TR (n = 10). The main barriers were technical issues and cost related to implement TR in physical therapy settings; and (4) Conclusions: There is a relatively high number of PTs with self-reported knowledge about TR, however facilities and usage were limited. The main barriers were technical issues, staff skills, and the high cost involved in the introduction of TR in the PT-based health care settings.
Muscularization of the Mesenchymal Outlet Septum during Cardiac Development

After the formation of the linear heart tube, it becomes divided into right and left components by the process of septation. Relatively late during this process, within the developing outflow tract, the initially mesenchymal outlet septum becomes muscularized as the result of myocardialization. Myocardialization is defined as the process in which existing cardiomyocytes migrate into flanking mesenchyme. Studies using genetically modified mice, as well as experimental approaches using in vitro models, demonstrate that Wnt and TGFβ signaling play an essential role in the regulation of myocardialization. They also show the significance of the interaction between cardiomyocytes, endocardial derived cells, neural crest cells, and the extracellular matrix. Interestingly, Wnt-mediated non-canonical planar cell polarity signaling was found to be a crucial regulator of myocardialization in the outlet septum and Wnt-mediated canonical β-catenin signaling is an essential regulator of the expansion of mesenchymal cells populating the outflow tract cushions.
Green, Brown, and Gray: Associations between Different Measurements of Land Patterns and Depression among Nursing Students in El Paso, Texas

Background: While greenness has been associated with lower depression, the generalizability of this association in arid landscapes remains undetermined. We assessed the association between depression and residential greenness, but also brownness and grayness among nursing students living in El Paso, Texas (the Chihuahuan desert). Methods: Depression was measured with the Patient Health Questionnaire-9 scale and greenness with the normalized difference vegetation index across three buffer sizes (i.e., 250, 500, and 1000 m). Using data from the National Land Cover Database, two additional measures of land patterns were analyzed: grayness and brownness. Structural equation models were used to assess the relationships of these land patterns to depression and quantify the indirect effects of peer alienation. Results: After adjusting for individual characteristics, at buffers 250 m, greenness was not associated with a decrease in the Incidence Rate Ratios (IRR) of depression (IRR, 0.51; 95% CI, 0.12–2.10); however, grayness and brownness were respectively associated with increases by 64% (IRR, 1.64; 95% CI, 1.07–2.52) and decreases by 35% (IRR, 0.65; 95% CI, 0.42–0.99). At buffer 250 m, peer alienation explained 17.43% (95% CI, −1.79–36.66) of the association between depression and brownness, suggesting a pathway to depression. Conclusions: We did not observe an association between depression and residential greenness in El Paso, Texas. However, we did observe a protective association between brownness and depression and an adverse association with grayness. These results have theoretical implications as they were based on commonly used frameworks in this literature, and adverse association of brownness (and the lack of greenness) and depression was expected.
Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis

Simple Summary Thyroid cancer is the most common type of endocrine system malignancy. The effective diagnosis, precise treatment, and better short and long-term prognosis of thyroid cancer patients have remained challenging. Non-coding RNAs (ncRNAs) are emerging molecules with diverse capabilities in initiating and promoting thyroid cancer upon dysregulation. The expression profile of these molecules could be used to detect thyroid cancer, determine the therapeutic approaches, and predict the patients’ survival. Thus, ncRNAs could have clinical significance in precision medicine. Abstract Thyroid cancer is the most prevalent malignancy of the endocrine system and the ninth most common cancer globally. Despite the advances in the management of thyroid cancer, there are critical issues with the diagnosis and treatment of thyroid cancer that result in the poor overall survival of undifferentiated and metastatic thyroid cancer patients. Recent studies have revealed the role of different non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) that are dysregulated during thyroid cancer development or the acquisition of resistance to therapeutics, and may play key roles in treatment failure and poor prognosis of the thyroid cancer patients. Here, we systematically review the emerging roles and molecular mechanisms of ncRNAs that regulate thyroid tumorigenesis and drug response. We then propose the potential clinical implications of ncRNAs as novel diagnostic and prognostic biomarkers for thyroid cancer.