Miracle-dz/UniFAR-FTUs huggingface dataset:
The regulation of p 21 Waf 1 / Cip 1 , p 27 Kip 1 and p 57 Kip 2 gene expression in response to hydrocortisone , progesterone and ß-estradiol in HL-60 myeloid leukemia cells

Steroid agents have crucial regulatory effects on cell differentiation and proliferation of different cell types. In this study, the influence of progesterone, ß-estradiol and hydrocortisone on the expression of cyclin dependent kinase inhibitor (CDKI) genes, p21, p27 and p57 was assessed in HL-60 myeloid leukemia cells. Although treatment with these steroid agents did not significantly change the morphology of HL-60 cells, expression levels of p21 and p27 genes were modulated. p57 gene was not expressed in HL-60 cells. The overall data implied that G1/S transition in myeloid leukemia cells may be primarily regulated through p21 and with a lesser extent through p27 expression upon incubation with steroids. [Turk J Cancer 2008;38(4):184-189]
Effects of Sitting Position on Uterine Activity During Labor

To determine which components of uterine activity are affected by different positions of labor, 116 intrauterine pressure records in the sitting and supine positions were analyzed in order to measure resting, contraction, and bearing down pressures. The resting pressure in the sitting position showed consistent elevation compared to the supine position, while the contraction pressure did not differ strikingly in the two positions. The bearing down pressure in the sitting position for nulliparas during the second stage and for multiparas at the time of the 8− to 10-cm dilation was significantly higher than that in the supine position. Also, the sitting position led to a significantly shorter duration of the second stage in nulliparas and the 5− to 10-cm dilation period in multiparas. These findings suggest that the maternal position does not affect uterine contractility, that the increased resting pressure in the sitting position is of some importance in supplementing the downward delivery force, and that the increased bearing down pressure in the sitting position could help to significantly shorten the duration of labor.
Wpływ bliskości organizacyjnej partnerów transakcji na poziom integracji poakwizycyjnej

The aim of this paper is to analyze a link between a level of organization proximity of the merging companies and the range of integration activities performed on the post-transaction stage. In the conducted research it was assumed that the more similar the companies which are the partners of transactions in a meso dimension the bigger its dynamics is. The paper presents the research results on 5 M&A transactions in the companies of a pharmaceutical sector in the years 2008–2010. In the research there was a conviction that the evaluation of the integration effects should be done at least 2–3 years after the transaction.
Pancreas transplantation in the mouse.

BACKGROUND Pancreas transplantation is the only established treatment to achieve long-term normoglycemia and insulin independence in patients with insulin-dependent diabetes mellitus. However, many complications both during and post-transplantation have limited the progress of pancreas transplantation. Mice are the widely used laboratory animals that have been used to establish pancreas transplant models. The pathogenesis and the treatment of pancreas allograft rejection have been studied during the last twenty years. This review introduces four different mouse pancreas transplantation models established by different centers. DATA SOURCES We reviewed the three mostly reported mouse pancreas transplantation models in the literature (PubMed), and compared them with a novel mouse model established at our center. RESULTS In this review, four different models of mouse pancreas transplantation were compared in terms of surgical technique, immediate success rate, advantages and disadvantages. CONCLUSIONS The mouse model is a useful tool to study pancreas transplantation-related diseases and their treatment. The findings from this model help to improve human pancreas transplantation in the future.
Human t‐cell leukemia virus: Causative roles in development of adult t‐cell leukemia and provirus integration into leukemic cell DNA

Human T‐cell leukemia virus (HTLV) was isolated from a cutaneous T‐cell lymphoma patient by Gallo and his colleagues (Poiesz et al., 1980) and adult T‐cell leukemia virus (ATLV) was isolated from patients with adult T‐cell leukemia (ATL) in Japan (Yoshida et al., 1982). Originally, these two viral isolates were thought to be different since they were isolated from apparently different tumors. However, we have shown that HTLV in the Caribbean and ATLV in Japan are the same virus (Watanabe et al., 1983, 1984) and the patient from which HTLV was isolated was identified as an atypical case of ATL (Bunn et al., 1983).
Sensitivity analysis in Bayesian generalized linear mixed models for binary data

Generalized linear mixed models (GLMMs) enjoy increasing popularity because of their ability to model correlated observations. Integrated nested Laplace approximations (INLAs) provide a fast implementation of the Bayesian approach to GLMMs. However, sensitivity to prior assumptions on the random effects precision parameters is a potential problem. To quantify the sensitivity to prior assumptions, we develop a general sensitivity measure based on the Hellinger distance to assess sensitivity of the posterior distributions with respect to changes in the prior distributions for the precision parameters. In addition, for model selection we suggest several cross-validatory techniques for Bayesian GLMMs with a dichotomous outcome. Although the proposed methodology holds in greater generality, we make use of the developed methods in the particular context of the well-known salamander mating data. We arrive at various new findings with respect to the best fitting model and the sensitivity of the estimates of the model components.
Resource Based View (RBV) of Competitive Advantages: Importance, Issues and Implications

The Resource based view (RBV) analyzes and interpret internal resources of the organizations and emphasizes resources and capabilities in formulating strategy to achieve sustainable competitive advantages. Resources may be considered as inputs that enable firms to carry out its activities. Internal resources and capabilities determine strategic choices made by firms while competing in its external business environment. According to RBV, not all the resources of firm will be strategic resources. Competitive advantage occurs only when there is a situation of resource heterogeneity (different resources across firms) and resource immobility (the inability of competing firms to obtain resources from other firms).
Left Ventricular Ejection Fraction and Absence of ACE Inhibitor/Angiotensin II Receptor Blocker Predicts Appropriate Defibrillator Therapy in the Primary Prevention Population

Introduction: Implantable cardioverter defibrillators (ICD) significantly reduce mortality in patients with left ventricular (LV) dysfunction. However, little is known of the predictors of appropriate device activation in the primary prevention population. The aim of the present study was to determine predictors of appropriate device therapy in patients receiving ICDs for primary prevention.
Special topic: molecular mechanism of muscle contraction. General introduction.

Contraction of striated muscle occurs when actin and myosin filaments slide past each other (12, 15). It is generally accepted that this process is driven by parts of the myosin molecules, the cross-bridges, which protrude from the myosin-containing thick filaments and cyclically interact with the actin in the thin filaments as ATP is hydrolyzed (7, 10, 11, 14). In studying the detailed mechanism of the cyclic cross-bridge action, several approaches are available: biochemical studies of the isolated proteins in solution, physiological measurements of muscle fiber mechanics and energetics, and structural stud­ ies using electron microscopy, X-ray diffraction, and spectroscopic probes.
Perspective on Arbitrage Pricing Theory

The development of financial equilibrium asset pricing models has taken major importance in the present financial theory research world. These models are extensively tested for developed markets. Focusing on arbitrage pricing theory, this paper tries to analyze its effect in the Indian stock market. The advantages of arbitrage pricing theory (APT) over the capital asset pricing model (CAPM) (single factor) have been dealt with in this paper.
Business Model Innovation in a Circular Economy Reasons for Non-Acceptance of Circular Business Models

Purpose The overall aim of this paper is to develop a new conceptual framework for business model innovation in a circular economy and to explore the reasons for consumer non-adoption of business models in this context. Design/methodology/approach – The study is based on existing work in mostly professional or forbusiness publications and develops a conceptual model by clustering and abstraction. For developing hypotheses on motives for consumer non-adoption the author refers to existing empirical research in various related fields. Findings – The first part of the paper demonstrates that, despite wording differences, a predominant agreement on a basic structure for new business models in a circular economy has emerged in the field. The second part provides evidence that the adoption of circular economy business models will depend upon changing consumer habits and routines by leveraging the impact of non-functional motives, as well as subjective and moral norms. Practical implications – For practitioners working on new innovative business models in the realm of the circular economy this paper provides a basic framework for clustering their concepts. By learning about consumer motives leading to non-adoption, this paper also provides support for designing better and more successful business models. Originality/value – This paper develops a new holistic framework for the emerging topic of circular economy business models.
Extracorporeal shock waves in the treatment of nonunions.

BACKGROUND Nonunion remains a major complication after skeletal trauma. In the last decade, extracorporeal shock wave therapy has become a common tool for the treatment of nonunions. To date, no prospective, randomized trial has been conducted to show the efficacy of this form of treatment. METHODS This study was performed to determine the value of extracorporeal shock wave therapy for nonunions. Previous published results in the literature and our own clinical results were analyzed and related to the natural history of bony union. RESULTS No study has proven that extracorporeal shock wave therapy improves bone healing. Clinical studies reporting the acceleration of union after application of shock waves instead seem to misinterpret the natural history of bony union. CONCLUSION No evidence supports the treatment of pseudarthroses with extracorporeal shock waves. A randomized, prospective, clinical trial with a control group has to be performed before a final decision can be made regarding this indication for extracorporeal shock wave therapy.
Ded1p, a DEAD-box Protein Required for Translation Initiation in Saccharomyces cerevisiae, Is an RNA Helicase*

The Ded1 protein (Ded1p), a member of the DEAD-box family, has recently been shown to be essential for translation initiation in Saccharomyces cerevisiae. Here, we show that Ded1p purified from Escherichia coli has an ATPase activity, which is stimulated by various RNA substrates. Using an RNA strand-displacement assay, we show that Ded1p has also an ATP-dependent RNA unwinding activity. Hydrolysis of ATP is required for this activity: the replacement of ATP by a nonhydrolyzable analog or a mutation in the DEAD motif abolishing ATPase activity results in loss of RNA unwinding. We find that cells harboring a Ded1 protein with this mutated DEAD motif are nonviable, suggesting that the ATPase and RNA helicase activities of this protein are essential to the cell. Finally, RNA binding measurements indicate that the presence of ATP, but not ADP, increases the affinity of Ded1p for duplexversus single-stranded RNA; we discuss how this differential effect might drive the unwinding reaction.
ROLES OF T AND B LYMPHOCYTES I N T H E T E R M I N A T I O N OF UNRESPONSIVENESS TO AUTOLOGOUS THYROGLOBULIN IN MICE* BY JAMES A. CLAGETT:~ AND WILLIAM O. WEIGLE§

That a central immunological unresponsive state exists to our own body constituents is widely accepted. The precise role played by the various cell types of the lymphoid system in the maintenance or abrogation of this unresponsiveness to self remains unclear. A large number of nonself-antigens require the collaboration of thymus-derived (T) and bone marrow-derived (B) lymphocytes (1, 2). Although both T and B cells may be made unresponsive, only one cell type need be in order that the intact animal remain unresponsive (3). In a rabbit model, the cellular events in the termination of unresponsiveness to bovine serum albumin (BSA), 1 by the injection of cross-reacting albumins, were best explained by assuming that the T cells, but not the B cells, were unresponsive to BSA and to cross-reacting determinants on other albumins (4). Such a situation may explain the apparent ease with which unresponsiveness to self components may be abrogated in autoimmune disorders such as thyroiditis (5-7) and rheumatic fever (8). The present investigations were undertaken to directly assess by adoptive transfer, antigen-binding and antigen-suicide techniques, the interactions of T and B cells during the induction of autoantibody to syngeneic thyroglobulin (Tg) and during the production of thyroid lesions.
Large aspiny cells in the matrix of the rat neostriatum in vitro: physiological identification, relation to the compartments and excitatory postsynaptic currents.

1. Large aspiny neurons (20-60 microns diam) in the neostriatum were studied in an in vitro rat slice preparation by whole-cell recording to reveal physiological identification from medium-sized spiny projection cells (10-20 microns diam), relation to the patch and matrix compartments, and excitatory synaptic inputs. Recorded cells were identified by intracellular biocytin staining. Compartmental identification was made by calbindinD28K immunohistochemistry in fixed slices. 2. Large stained neurons were morphologically heterogeneous and had aspiny or sparsely spiny dendrites and dense local axonal branches. They were located in the matrix or on the patch-matrix border. Axonal branches of the large aspiny cells were preferentially distributed in the matrix and gave off terminal boutons there. Some of the secondary dendrites arising from stem dendrites running along the border, however, crossed compartment boundaries and made fine branches in a patch. 3. Large aspiny cells had less negative resting membrane potentials and lower thresholds for spike generation than medium spiny cells. They showed longer-duration and larger-amplitude afterhyperpolarizations (AHPs) than medium spiny cells. During hyperpolarizing current pulses, apparent resistance slowly reduced, and a prominent sag was observed in the voltage record, which was absent in medium spiny cells. The large aspiny cells showed no spontaneous firing but had a tendency to fire repetitive spikes in response to depolarizing current pulses, although spike interval tended to increase in later spikes. Spike frequency of large aspiny cells increased less with current intensity than that of medium spiny cells. 4. Most large aspiny cells were considered to belong to a single physiological class, although one large aspiny cells showed shorter-duration AHPs than both most other large aspiny cells and medium spiny cells, and little spike-frequency adaptation. 5. Excitatory postsynaptic currents (EPSCs) of large aspiny cells induced by intrastriatal stimulation had two components. An early, linear component was blocked by 10 microM 6-cyano-7-nitro-quinoxaline-2,3-dione (CNQX), a selective antagonist of non-N-methyl-D-aspartate (NMDA) receptors. A later component with a nonlinear current-voltage (I-V) relationship was blocked by 50 microM DL-2-amino-5-phosphonovaleric acid (DL-APV), a selective antagonist of NMDA receptors. 6. From these results, four conclusions can be drawn. 1) Most large aspiny neostriatal cells in the matrix, although they take heterogeneous shapes, belong to one physiological class with long-duration AHPs and a strong time-dependent component of anomalous rectification. (ABSTRACT TRUNCATED AT 400 WORDS)
Learning to search: structured prediction techniques for imitation learning

Modern robots successfully manipulate objects, navigate rugged terrain, drive in urban settings, and play world-class chess. Unfortunately, programming these robots is challenging, time-consuming and expensive; the parameters governing their behavior are often unintuitive, even when the desired behavior is clear and easily demonstrated. Inspired by successful end-to-end learning systems such as neural network controlled driving platforms (Pomerleau, 1989), learning-based "programming by demonstration" has gained currency as a method to achieve intelligent robot behavior. Unfortunately, with highly structured algorithms at their core, modern robotic systems are hard to train using classical learning techniques. Rather than redefining robot architectures to accommodate existing learning algorithms, this thesis develops learning techniques that leverage the performance of modern robotic components. We begin with a discussion of a novel imitation learning framework we call Maximum Margin Planning which automates finding a cost function for optimal planning and control algorithms such as A*. In the linear setting, this framework has firm theoretical backing in the form of strong generalization and regret bounds. Further, we have developed practical nonlinear generalizations that are effective and efficient for real-world problems. This framework reduces imitation learning to a modern form of machine learning known as Maximum Margin Structured Classification (Taskar et al., 2005); these algorithms, therefore, apply both specifically to training existing state-of-the-art planners as well as broadly to solving a range of structured prediction problems of importance in learning and robotics. In difficult high-dimensional planning domains, such as those found in many manipulation problems, high-performance planning technology remains a topic of much research. We close with some recent work which moves toward simultaneously advancing this technology while retaining the learnability developed above. Throughout the thesis, we demonstrate our algorithms on a range of applications including overhead navigation, quadrupedal locomotion, heuristic learning, manipulation planning, grasp prediction, driver prediction, pedestrian prediction, optical character recognition, and LADAR classification.
Spectral Analysis of physiological parameters for emotion detection

This paper intends to be a literature review in the field of emotions detection using spectral analysis of neurological signals. It also shows the great boom in Brain Computer Interfaces (BCI) applications. Explains the research methodology used for this type of projects, and finally it highlights the results of several studies that have been done in this area.
Selective Actions of Novel Allosteric Modulators Reveal Functional Heteromers of Metabotropic Glutamate Receptors in the CNS

Metabotropic glutamate (mGlu) receptors play important roles in regulating CNS function and are known to function as obligatory dimers. Although recent studies have suggested heterodimeric assembly of mGlu receptors in vitro, the demonstration that distinct mGlu receptor proteins can form heterodimers or hetero-complexes with other mGlu subunits in native tissues, such as neurons, has not been shown. Using biochemical and pharmacological approaches, we demonstrate here that mGlu2 and mGlu4 form a hetero-complex in native rat and mouse tissues which exhibits a distinct pharmacological profile. These data greatly extend our current understanding of mGlu receptor interaction and function and provide compelling evidence that mGlu receptors can function as heteromers in intact brain circuits.
Women's sexual pain and its management.

INTRODUCTION Approximately 15% of women have chronic dyspareunia that is poorly understood, infrequently cured, often highly problematic, and distressing. Chronic dyspareunia is an urgent health issue. AIM To provide recommendations/guidelines concerning state-of-the-art knowledge for the assessment and management of women's sexual pain disorders. METHODS An international consultation, in collaboration with the major sexual medicine associations, assembled over 200 multidisciplinary experts from 60 countries into 17 committees. One six-member committee focused on women's sexual pain disorders, developing recommendations over a 2-year period. MAIN OUTCOME MEASURE Expert opinion was based on grading of evidence-based medical literature, widespread internal committee discussion, public presentation, and debate. RESULTS There is increasing evidence for the role of neuropathic pain mechanisms in the pathophysiology of sexual pain disorders. Empirical literature has demonstrated the comorbid presence of clinical psychopathology. With regard to the pathophysiologic role of the pelvic floor and sexual pain disorders, studies reveal that (i) differentiation between vaginismus and dyspareunia using clinical tools is difficult; (ii) vaginal spasms have not been identified; (iii) physical therapists can differentiate vaginismic women from matched controls based on muscle tone/strength differences; (iv) the traditional treatment of vaginismus with vaginal "dilatation" plus psycho-education, desensitization, and so forth is not evidence-based; (v) pelvic floor muscle tone/strength measures for women suffering from vulvar vestibulitis syndrome are intermediate between those of women with vaginismus and no-pain controls; and (vi) the pelvic floor musculature is indirectly innervated by the limbic system and highly reactive to emotional stimuli and states. Pelvic floor therapies for dyspareunia may be effective. CONCLUSION Recommendations include (i) revising the definitions of vaginismus and dyspareunia; (ii) integration of treatment approaches; (iii) validation of nonspecific treatment effects; (iv) controlled studies to test interventions; and (v) sexuality education to help prevent sexual pain.
Peyronie's disease: a "triple oxygenant therapy".

OBJECTIVES To evaluate the effects of upregulators of nitric oxide in one patient with Peyronie’s disease, after non significant improvement following intracavernosal verapamil. METHODS A 20-years-old Caucasian male presented with penile induration in flaccid state, persistent during erection and associated with mild pain at third middle of penis. After treatment with intracavernosal verapamil for 4 months with relief of penile discomfort, followed by counseling on the use of penile extender for at least 6 hours per day, he was prescribed pentoxifylline associated with tadalafil plus levo-arginine, propionil-carnitine and Vitamin B3. RESULTS After almost 2 years, the septal thickness was reduced at ultrasound evaluation after this “triple oxygenant therapy”. CONCLUSION NO-iNOS biology in Peyronie patients is the very protagonist in modulating penile fibrosis through up-regulation of NO-cGMP pathway that influences penile health by preventing and reversing fibrosis in the tunical albuginea.
Experiments on the Effects of Hyperbaric Oxygen on Flap Survival in the Pig

The use of hyperbaric oxygen has been advocated as a method of improving survival of ischemic flaps. Experiments were done in the pig using modern flap designs and hyperbaric oxygen protocols that have been reported to be effective in rodents. The results of these experiments indicate that hyperbaric oxygen is not effective in improving flap survival in the pig.