Miracle-dz/UniFAR-FTUs huggingface dataset:
Length of Excitation Wave and Susceptibility to Reentrant Atrial Arrhythmias in Normal Conscious Dogs

We calculated the wavelength of the atrial impulse in chronically instrumented conscious dogs by measuring both conduction velocity and refractory period: wavelength = refractory period × conduction velocity. Implantation of multiple stimulating and recording electrodes allowed wavelength determination at four different areas: the right and left parts of Bachmann's bundle and the free walls of the right and left atria. During programmed electrical stimulation, three types of arrhythmias were observed: rapid repetitive responses, atrial flutter, and atrial fibrillation. During normal rhythm, the wavelength of the atrial impulse varied between 14 and 18 cm. Premature beats had a shorter wavelength, depending on the degree of prematurity. Premature beats that evoked rapid repetitive responses showed a critical shortening of the wavelength below 12.3 cm. Episodes of atrial flutter were induced at a wavelength below 9.7 cm, while fibrillation occurred at wavelengths shorter than 7.8 cm. We correlated the induction of these arrhythmias with the values of refractory period, conduction velocity, and wavelength during control and during administration of several drugs. Intravenous administration of acetylcholine shortened the wavelength by 30–40%, mainly because of refractory period shortening. Both propafenone and lidocaine had strong but opposite effects on refractoriness and conduction and, consequently, little effect on the wavelength. Quinidine markedly prolonged the refractory period, but prolongation of wavelength was less because of a simultaneous decrease in conduction velocity. d-Sotalol also increased refractory period, but because it had no appreciable effect on conduction velocity, this drug was the most effective in prolongation of wavelength. Linear discriminant analysis of the data showed that the refractory period and the conduction velocity each were poor parameters to predict the occurrence of the different arrhythmias (predictive value 48% and 38%, respectively). The combination of both properties, however, as expressed in the wavelength, was a more reliable index that predicted the induction of the different arrhythmias correctly in 75% of the cases. We conclude that the wavelength is a useful parameter for evaluating antiarrhythmic drugs.
Stock Market Prediction and Forecasting Techniques: A Survey

This paper surveys recent literature in the area of Neural Network, Data Mining, Hidden Markov Model and Neuro-Fuzzy system used to predict the stock market fluctuation. Neural Networks and Neuro-Fuzzy systems are identified to be the leading machine learning techniques in stock market index prediction area. The Traditional techniques are not cover all the possible relation of the stock price fluctuations. There are new approaches to known in-depth of an analysis of stock price variations. NN and Markov Model can be used exclusively in the finance markets and forecasting of stock price. In this paper, we propose a forecasting method to provide better an accuracy rather traditional method. Forecasting stock return is an important financial subject that has attracted researchers’ attention for many years. It involves an assumption that fundamental information publicly available in the past has some predictive relationships to the future stock returns
Working Memory Impairments in Children with Attention-Deficit Hyperactivity Disorder With and Without Comorbid Language Learning Disorders

Our objectives were to examine whether children with attention-deficit hyperactivity disorder (ADHD) are impaired on one or more components of working memory (WM) independent of comorbid language learning disorders, and whether WM impairments are more strongly related to symptoms of inattention than to symptoms of hyperactivity-impulsivity. Four groups of children participated: ADHD (n = 62); ADHD+RD/LI (n = 32); RD/LI (n = 15); and a typically developing comparison group (n = 34). Four simple and brief measures of WM were used that varied in modality (auditory-verbal; visual-spatial) and processing demands (temporary storage versus manipulation of information). Children with ADHD without comorbid language learning disorders exhibited deficits in visual-spatial storage and verbal and visual-spatial central executive (C.E.) functions that were independent of comorbid psychiatric disorders. Children with language learning disorders, regardless of comorbidity with ADHD, exhibited impairments in both verbal and spatial storage as well as C.E. domains of WM. Symptoms of inattention, but not symptoms of hyperactivity/impulsivity, predicted performance on verbal and visual-spatial C.E. measures independent of age, verbal cognitive ability, and reading and language performance. Findings are consistent with data implicating neuropsychological impairments in ADHD. The dimensional results are also consistent with prior research demonstrating the neuropsychological impairments are more strongly associated with the inattention symptom dimension than with the hyperactive-impulsive dimension.
From Big Data to Deep Learning: A Leap Towards Strong AI or 'Intelligentia Obscura'?

Astonishing progress is being made in the field of artificial intelligence (AI) and particularly in machine learning (ML). Novel approaches of deep learning are promising to even boost the idea of AI equipped with capabilities of self-improvement. But what are the wider societal implications of this development and to what extent are classical AI concepts still relevant? This paper discusses these issues including an overview on basic concepts and notions of AI in relation to big data. Particular focus lies on the roles, societal consequences and risks of machine and deep learning. The paper argues that the growing relevance of AI in society bears serious risks of deep automation bias reinforced by insufficient machine learning quality, lacking algorithmic accountability and mutual risks of misinterpretation up to incrementally aggravating conflicts in decision-making between humans and machines. To reduce these risks and avoid the emergence of an intelligentia obscura requires overcoming ideological myths of AI and revitalising a culture of responsible, ethical technology development and usage. This includes the need for a broader discussion about the risks of increasing automation and useful governance approaches to stimulate AI development with respect to individual and societal well-being.
A Comprehensive Profile Analysis of the Effect of Job Embeddedness on Turnover Intention among New Generation of Rural Migrant Workers in China: Based on PLS-SEM

This paper aimed to examine the relationship between organization embeddedness (OE), community embeddedness (CE) and turnover intention in the context of manufacturer sector in China. A 37-item questionnaire was filled by 384 new generation of rural migrant workers. Data were examined through a first-order of reflective model (SME1) and a two-stage of second-order reflective-formative hierarchical model (SME2) with the technical of Partial Least Squares. The empirical test results indicated that both OE and CE negative and significant related to turnover intention. When further disaggregated the components of OE and CE into the three sub-dimensions of fit, links, and sacrifice, this study found that causal indicator model of job embeddedness predict more variance of turnover intention than reflective model. Moreover, this study found that OEF, OES, CEF, and CES negative and significantly associated with turnover intention, while OEL positive related to turnover intention. Additionally, CEL did not show significant impact on turnover intention. The study concludes with several implications and recommendations for future research.
Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model

Epidemiological studies support a link between melanoma risk and UV exposure early in life, yet the molecular targets of UV's mutagenic actions are not known. By using well characterized murine models of melanoma, we provide genetic and molecular evidence that identifies components of the Rb pathway as the principal targets of UV mutagenesis in murine melanoma development. In a melanoma model driven by H-RAS activation and loss of p19ARF function, UV exposure resulted in a marked acceleration in melanoma genesis, with nearly half of these tumors harboring amplification of cyclin-dependent kinase (cdk) 6, whereas none of the melanomas arising in the absence of UV treatment possessed cdk6 amplification. Moreover, UV-induced melanomas showed a strict reciprocal relationship between cdk6 amplification and p16INK4a loss, which is consistent with the actions of UV along the Rb pathway. Most significantly, UV exposure had no impact on the kinetics of melanoma driven by H-RAS activation and p16INK4a deficiency. Together, these molecular and genetic data identify components of the Rb pathway as critical biological targets of UV-induced mutagenesis in the development of murine melanoma in vivo.
25-Hydroxyvitamin D is associated with plasma renin activity and the pressor response to dietary sodium intake in Caucasians

Introduction: Concentrations of 1,25-hydroxyvitamin D have been positively associated with dietary sodium and salt sensitivity (SS) of blood pressure (BP), and inversely with plasma renin activity (PRA). We investigated the association between PRA and 25-hydroxyvitamin D (25OHD), the most clinically relevant vitamin D metabolite, and whether 25OHD associates with SS of BP in renin phenotypes of hypertension. Methods: We performed cross-sectional analyses on 223 Caucasian subjects with hypertension maintained in high and low dietary sodium balance. Subjects were distinguished as having low-renin (LR) or normal-renin (NR) hypertension. Multivariable linear regression was used to evaluate adjusted relationships. Results: Increasing 25OHD concentrations were inversely associated with PRA (p < 0.05) on both salt diets. Furthermore, 25OHD was associated with SS of BP in LR hypertension (b = 0.62, p = 0.04), but not in NR hypertension (b = 0.06, p = 0.59). In an adjusted multivariable interaction model, renin status (LR vs. NR) was a significant effect modifier of the relationship between 25OHD and SS of BP (p = 0.04). Conclusions: Our findings suggest that 25OHD is inversely associated with PRA and positively associated with SS of BP in LR hypertension subjects. These results extend and support prior evidence indicating an interaction between dietary sodium, the RAS, and vitamin D that influences BP in hypertension.
Biological constraints that limit compensation of a common skeletal trait variant lead to inequivalence of tibial function among healthy young adults

Having a better understanding of how complex systems like bone compensate for the natural variation in bone width to establish mechanical function will benefit efforts to identify traits contributing to fracture risk. Using a collection of pQCT images of the tibial diaphysis from 696 young adult women and men, we tested the hypothesis that bone cells cannot surmount the nonlinear relationship between bone width and whole bone stiffness to establish functional equivalence across a healthy population. Intrinsic cellular constraints limited the degree of compensation, leading to functional inequivalence relative to robustness, with slender tibias being as much as two to three times less stiff relative to body size compared with robust tibias. Using Path Analysis, we identified a network of compensatory trait interactions that explained 79% of the variation in whole‐bone bending stiffness. Although slender tibias had significantly less cortical area relative to body size compared with robust tibias, it was the limited range in tissue modulus that was largely responsible for the functional inequivalence. Bone cells coordinately modulated mineralization as well as the cortical porosity associated with internal bone multicellular units (BMU)‐based remodeling to adjust tissue modulus to compensate for robustness. Although anecdotal evidence suggests that functional inequivalence is tolerated under normal loading conditions, our concern is that the functional deficit of slender tibias may contribute to fracture susceptibility under extreme loading conditions, such as intense exercise during military training or falls in the elderly. Thus, we show the natural variation in bone robustness was associated with predictable functional deficits that were attributable to cellular constraints limiting the amount of compensation permissible in human long bone. Whether these cellular constraints can be circumvented prophylactically to better equilibrate function among individuals remains to be determined. © 2011 American Society for Bone and Mineral Research
MODEL ESTIMASI GARCH DALAM MENGUKUR KINERJA NILAI TUKAR RUPIAH

The exchange rate is determined by the demand and supply relationship of the currency. If the demand for a currency increases, while the supply remains or even decreases, then the exchange rate will rise vice versa. The ups and downs of exchange rates on the money market indicate the magnitude of the volatility that occurs in the currency of a State against the currencies of other countries. The volatility phenomenon indicates difficulty in analyzing the exchange rate. Increasing volatility indicates an even greater movement of currency exchange rates even if currency exchange rates experience extreme volatility resulting in economic instability both from the micro and macro sides. The high volatility seen from the pattern of price movements that occur in financial markets, and the impact that can be generated from the high volatility data is the error that will have a variance that is not constant. That is, a relatively high data variability at a time indicates the presence of heteroscedasticity. Heteroscedasticity can lead to errors in drawing a conclusion to the estimated model obtained. Therefore, we need a model that is able to solve the problem that is Generalized Autoregressive Conditional Heteroscedasticity (GARCH) model in order to get more accurate estimation model to estimate exchange rate. From the simulation result, all data contain the volatility seen from the result of heteroscedasticity test, and obtained estimation model for all data.
Design of Highly Efficient Pr3+-Doped Chalcogenide Fiber Laser

This letter describes the design of a medium infrared laser based on a double clad structure of praseodymium (Pr<sup>3+</sup>)-doped chalcogenide glass. The overlap of the emission cross sections of Pr<sup>3+</sup> in the transitions (<sup>3</sup>F<sub>2</sub>, <sup>3</sup>H<sub>6</sub> <inline-formula> <tex-math notation="LaTeX">$\to $ </tex-math></inline-formula><sup>3</sup>H<sub>5</sub>, and <sup>3</sup>H<sub>5</sub> <inline-formula> <tex-math notation="LaTeX">$\to $ </tex-math></inline-formula><sup>3</sup>H<sub>4</sub>) enables both transitions to simultaneously produce a single coherent wavelength in the range between 3.7 and <inline-formula> <tex-math notation="LaTeX">$4.6~\mu \text{m}$ </tex-math></inline-formula>. A single pair fiber Bragg grating at the overlapping transition wavelengths is used to avoid fabrication complexity of a cascade pumping scheme. In addition, the proposed design takes advantages of the fact that one excited ion will radiate two photons in the overlapping transition wavelengths. In this letter, the laser performance is tested as a function of fiber length, pump power, signal wavelength, fiber background loss, and Pr<sup>3+</sup>-doped concentration. The modeling results reveal that 48% of slope efficiency could be produced when the fiber losses are about 1 dB/m.
Surface Structure of Intact Cells and Spheroplasts of Pseudomonas aeruginosa

This report describes the ultrastructural features of Pseudomonas aeruginosa after freeze-etching of intact cells and enzymatically prepared spheroplasts. Freeze-etching of intact cells revealed two convex layers of the cell wall and particles within the hydrophobic interior of the cell membrane. Areas of the membrane free of particles were sometimes elevated in the form of rather large dome-shaped structures. Spheroplasts were formed from intact cells by the addition of trypsin to a reaction mixture of lysozyme and ethylenediaminetetraacetic acid. Spheroplasts contained the outer lipoid layer of the cell wall. It was possible to observe this cell wall layer in freeze-etch preparations of spheroplasts. The spheroplast membrane like that of intact cells was cleaved along a central plane to expose particles and particle-free areas.
Time of treatment influences the appearance of drug-resistant parasites in Plasmodium falciparum infections

A deterministic mathematical model which predicts the probability of developing a new drug-resistant parasite population within the human host is reported. The model incorporates the host's specific antibody response to PfEMP1, and also investigates the influence of chemotherapy on the probability of developing a viable drug-resistant parasite population within the host. Results indicate that early treatment, and a high antibody threshold coupled with a long lag time between antibody stimulation and activity, are risk factors which increase the likelihood of developing a viable drug-resistant parasite population. High parasite mutation rates and fast PfEMP1 var gene switching are also identified as risk factors. The model output allows the relative importance of the various risk factors as well as the relationships between them to be established, thereby increasing the understanding of the conditions which favour the development of a new drug-resistant parasite population.
Article in press-uncorrected proof Assessment of the Nova StatSensor whole blood point-of-care creatinine analyzer for the measurement of kidney function in screening for chronic kidney disease

Background: Point-of-care testing for creatinine using a fingerprick sample and resultant estimated glomerular filtration rate has potential for screening for chronic kidney disease in community settings. This study assessed the applicability of the Nova StatSensor creatinine analyzer for this purpose. Methods: Fingerprick samples from 100 patients (63 renal, 37 healthy volunteers; range 46–962 mmol/L) were assayed using two StatSensor analyzers. Lithium heparin venous plasma samples collected simultaneously were assayed in duplicate using the isotope dilution mass spectrometryaligned Roche Creatinine Plus enzymatic assay on a Hitachi Modular P unit. Method comparison statistics and the ability of the StatSensor to correctly categorise estimated glomerular filtration rate above or below 60 mL/min were calculated preand post-alignment with the laboratory method. Results: StatSensor 1 creatinine results (y) were much lower than the laboratory (ys0.75xq10.2, average bias –47.3, 95% limits of agreement –208 to q113 mmol/L). For estimated glomerular filtration rates above or below 60 mL/min, 100% and 87% of results respectively agreed with the laboratory estimated glomerular filtration rate (79% and 96% post-alignment). StatSensor 2 statistics were similar. The 95% limits of agreement between StatSensor creatinine results were –35 to q34 mmol/L. Conclusions: Isotope dilution mass spectrometry alignment of the StatSensor will identify most patients with estimated *Corresponding author: Mark Shephard, Associate Professor, Director and Senior Research Fellow, Community Point-of-Care Services, Flinders University Rural Clinical School, Flinders University, GPO Box 2100, Adelaide, South Australia 5001, Australia E-mail: Mark.Shephard@flinders.edu. au Received December 22, 2009; accepted March 1, 2010; previously published online May 19, 2010 glomerular filtration rate -60 mL/min, but there will be many falsely low estimated glomerular filtration rate results that require laboratory validation. Creatinine results need improvement. Clin Chem Lab Med 2010;48:1113–9.
Modern democratic federations in the digital age: the conditions and prerequisites of electronic government (de-)centralization

This thesis discusses the process of administrative (de-)centralization of electronic government in 11 democratic federations. The research is comparative in nature and process-tracing was used as a primary data analysis method in order to identify the factors that led to the centralization or decentralization of the three electronic government areas. The following factors were discussed in the study: economic resources, the quality of public services, the quality of electronic government and the political orientation of the majority party in the parliament. The work not only analyzes the prerequisites for the actions of the central government regarding the electronic government system aimed at redistributing intergovernmental power-relations but also categorizes these actions in the context of redistribution of administrative powers. Based on the results of the study, the factors of centralization or decentralization of each electronic government area are highlighted, and the main strategies are outlined. As the thesis argues, the desire of federal center to improve the quality of public services and quality of electronic government leads to the decentralization of electronic services area with the centralization of electronic administration, while increasing of economic resources leads to greater centralization of both electronic administration and electronic services.
Up-regulation of PIK3CA promotes metastasis in gastric carcinoma.

AIM To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase (PI3K)/Akt pathway. METHODS mRNA and protein levels of PIK3CA were assessed, respectively, by real-time quantitative polymerase chain reaction and immunohistochemistry in specimens of normal gastric mucosa, primary foci and lymph node and distant metastasis of gastric cancer. Akt and phosphorylated Akt protein were also examined by Western blotting in these tissues, in order to analyze the effect of PIK3CA expression level changes on the activation of PI3K/Akt signaling pathway. RESULTS PIK3CA mRNA in lymph node metastasis were approximately 5 and 2 folds higher, respectively, than that in the corresponding normal gastric mucosa and primary gastric cancer tissues (P < 0.05), while no statistical significance was found compared with distant metastasis. Immunohistochemically, PIK3CA protein expression was discovered in 7 (35%) specimens of 20 primary foci vs 10 (67%) of 15 of lymph node metastasis or 11 (61%) of 18 of distant metastasis (35% vs 67%, P = 0.015; 35% vs 61%, P = 0.044). With the increased level of PIK3CA expression, the total Akt protein expression remained almost unchanged, but p-Akt protein was upregulated markedly. CONCLUSION Increased expression of PIK3CA is expected to be a promising indicator of metastasis in gastric cancer. Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling.