Miracle-dz/UniFAR-FTUs huggingface dataset:
Steady-state Mantle-Melt Interactions in One Dimension: I. Equilibrium Transport and Melt Focusing

Mantle–melt interaction during melt transport is explored in one dimension and steady state. We reconsider the equivalence between one-dimensional steady equilibrium transport and batch melting. In the absence of diffusion and radioactivity, conservation of mass flux requires that the major and trace element compositions of melt and solid at each point are the same as is generated by batch melting the source composition at the same pressure and temperature. Energy conservation requires that temperature and extent of melting are independent of melt migration except for irreversible source terms related to viscous compaction and gravitational energy release. The equivalence of phase compositions at each pressure between steady-state equilibrium transport and batch melting simplifies melt transport calculations. We examine the effects of increasing the melt flux to simulate melt focusing by channeling or by two-dimensional flow with converging melt streamlines. Melt focusing modifies the mineralogy of both residual matrix and erupted melt. We use MELTS calculations to model the formation of dunite by this mechanism and quantify the melt flux required to exhaust orthopyroxene from the residue as a function of pressure. The model dunites are found to be similar to natural dunites observed in the mantle section of ophiolite sequences.
Chromatin organization and virus gene expression

Many viruses introduce DNA into the host‐cell nucleus, where they must either embrace or confront chromatin factors as a support or obstacle to completion of their life cycle. Compared to the eukaryotic cell, viruses have compact and rapidly evolving genomes. Despite their smaller size, viruses have complex life cycles that involve dynamic changes in DNA structure. Nuclear entry, transcription, replication, genome stabilization, and virion packaging involve complex changes in chromosome organization and structure. Chromatin dynamics and epigenetic modifications play major roles in viral and host chromosome biology. In some cases, viruses may use novel or viral‐specific epigenetic modifying activities, which may reflect variant pathways that distinguish their behavior from the bulk of the cellular chromosome. This review examines several recent discoveries that highlight the role of chromatin dynamics in the life cycle of DNA viruses. J. Cell. Physiol. 216: 295–302, 2008. © 2008 Wiley‐Liss, Inc.
Global Identification of Multiple Substrates for Plasmodium falciparum SUB1, an Essential Malarial Processing Protease

ABSTRACT The protozoan pathogen responsible for the most severe form of human malaria, Plasmodium falciparum, replicates asexually in erythrocytes within a membrane-bound parasitophorous vacuole (PV). Following each round of intracellular growth, the PV membrane (PVM) and host cell membrane rupture to release infectious merozoites in a protease-dependent process called egress. Previous work has shown that, just prior to egress, an essential, subtilisin-like parasite protease called PfSUB1 is discharged into the PV lumen, where it directly cleaves a number of important merozoite surface and PV proteins. These include the essential merozoite surface protein complex MSP1/6/7 and members of a family of papain-like putative proteases called SERA (serine-rich antigen) that are implicated in egress. To determine whether PfSUB1 has additional, previously unrecognized substrates, we have performed a bioinformatic and proteomic analysis of the entire late asexual blood stage proteome of the parasite. Our results demonstrate that PfSUB1 is responsible for the proteolytic processing of a range of merozoite, PV, and PVM proteins, including the rhoptry protein RAP1 (rhoptry-associated protein 1) and the merozoite surface protein MSRP2 (MSP7-related protein-2). Our findings imply multiple roles for PfSUB1 in the parasite life cycle, further supporting the case for considering the protease as a potential new antimalarial drug target.
A method for eye detection based on SVD transforms

A set of transforms (SVD transforms) were introduced in (Shahshahani and Tavakoli Targhi) for understanding images. These transforms have been applied to some problems in computer vision including segmentation, detection of objects in a texture environment, classification of textures, detection of cracks or other imperfections, etc. This technique is shown to be applicable to determination of the location of eyes in a facial image. This method makes no use of color cues, prior geometric knowledge or other assumptions and does not require training. It is also insensitive to local perturbations in lighting, change of orientation and pose, scaling, and complexity of the background including indoor and outdoor environments. The method can be used for eye tracking and has applications to face recognition. It has also been used in animal eye detection and differentiation. © 2007 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 16, 222–229, 2006
Catching up with the Data: Research Issues in Mining Data Streams

In many domains, data now arrives faster than we are able to mine it. To avoid wasting this data, we must switch from the traditional \one-shot" data mining approach to systems that are able to mine continuous, high-volume, open-ended data streams as they arrive. In this paper we identify some desiderata for such systems, report on our recent work realizing them
Schincalide A, a Schinortriterpenoid with a Tricyclo[5.2.1.0(1,6)]decane-Bridged System from the Stems and Leaves of Schisandra incarnate.

Schincalide A (1), an unprecedented schinortriterpenoid possessing a tricyclo[5.2. 1.0(1,6)]decane-bridged system, was isolated from the stems and leaves of Schisandra incarnate. The structure with absolute configuration of 1 was determined by extensive spectroscopic analyses and single-crystal X-ray diffraction. A hypothetical biosynthetic pathway of 1 was postulated.
Preparing to Work with Big Data in Proteomics – A Report on the HUPO‐PSI Spring Workshop

The Human Proteome Organisation Proteomics Standards Initiative (HUPO‐PSI) was established in 2002 with the aim of defining community standards for data representation in proteomics and facilitating data comparison, exchange and verification. The 2013 annual spring workshop was hosted by the University of Liverpool, UK and concentrated on updating and refining the existing standards in the light of new methodologies and technologies. To control the inflation of file sizes, strategies for file compression, particularly for mzML files, were explored. Best practices for encoding information such as protein grouping and PTM localisation were refined and documented. Additional example files for the mzQuantML format were designed to provide support for selected reaction monitoring techniques. Enhancements to the PSI Common Query Interface (PSICQUIC) and PSI‐MI XML were discussed. Finally, the group engaged in discussion on how the existing work of the HUPO‐PSI can be leveraged by the Metabolomics Standards Initiative to improve the capture of metabolite data.
Interaction dynamics of multiple mobile robots with simple navigation strategies

The global dynamic behavior of multiple interacting autonomous mobile robots with simple navigation strategies is studied. Here, the effective spatial domain of each robot is taken to be a closed ball about its mass center. It is assumed that each robot has a specified cone of visibility such that interaction with other robots takes place only when they enter its visibility cone. Based on a particle model for the robots, various simple homing and collision-avoidance navigation strategies are derived first. Then, an analysis of the dynamical behavior of the interacting robots in unbounded spatial domains is made. The article concludes with the results of computer simulation studies of two or more interacting robots.
[The effects of weight reduction in reversing fatty liver changes in overweight and obese patients].

OBJECTIVE To study the effects of weight loss on nonalcoholic steatohepatitis (NASH) in obese patients. METHODS It is a prospective study. Blood biochemical parameters were examined in 220 overweight or obese patients without alcoholic consumption and without detectable HBsAg. Ultrasonographic examination was performed by a fixed doctor. 45 obese patients followed a program of weight loss, including diet restriction, exercise or drug for a trial period of one year. Weight, blood biochemical tests and ultrasonic examination of liver were compared before and after the trial in all the patients. RESULTS 75.9% of the patients were diagnosed as NASH. Logistic regression analysis revealed that the risk factors of NASH were body mass index (BMI, beta = 0.926, P = 0.021), age (beta = 0.973, P = 0.021), 2-hour postprandial glucose (beta = 0.987, P = 0.012), 1-hour postprandial net insulin in serum (beta = 1.027, P = 0.032), waist circumference (beta = 1.091, P = 0.038)and low density lipoprotein cholesterol (beta = 0.980, P = 0.041). After the treatment, 65.7% of the patients with NASH improved. The level of ALT in these patients decreased significantly (P = 0.040). The improvement of NASH correlated positively with the reduction of BMI (beta = 3.032, P = 0.010), triglycerides (TG, beta = 1.041, P = 0.025) and waist circumference (beta = 1.115, P = 0.029). The decrease of ALT level correlated with the decrease of BMI (beta = 1.165, P = 0.002), TG (beta = 0.986, P = 0.005), waist circumference (beta = 0.736, P = 0.041), and the increase of high density lipoprotein cholesterol (beta = -0.772, P = 0.016). CONCLUSION NASH is one of the most important complications of obesity. Weight loss is the mainstay of treatment for obese patients.
PENGARUH KUALITAS PELAYANAN TERHADAP LOYALITAS NASABAH KREDIT KONSUMTIF: CITRA BANK DAN KEPUASAN NASABAH SEBAGAI VARIABEL MEDIATOR

The banking sector plays an important role to support economic growth. However, nowadays the banking industry is facing keen competition. The success of the bank in order to win the competition is determined by customer loyalty. One of bank that is fully aware of the high level of competition in the banking industry and the importance of customer loyalty is the Jambi Bank Branch Sungai Penuh. Among the broad factors that are able to impact customer loyalty namely banking image, customer satisfaction and service quality. The purpose of this research is to investigate the role of banking image and customer satisfaction as mediator variables on the relationship between service quality and customer loyalty. The population of this study is all customers of consumptive loans at Jambi Bank Branch Sungai Penuh which accounted for 371 customers. The numbers of useful samples were 193 customers by performing proportional cluster random sampling method. In order to conduct hypotheses development, this research performs simple, multiple and hierarchical regression analyses by using Statistical Package for Social Science (SPSS) version 19.0. The results of analysis display that 1) Service quality positively and significantly impacts customer loyalty. 2) Service quality positively and significantly impacts banking image. 3) Service quality positively and significantly impacts customer satisfaction. 4) Banking image and customer satisfaction positively and significantly impact customer loyalty 5) Banking image and customer satisfaction are found as full mediator on the relationship between service quality and customer loyalty. The results of the study provide practical implication to head office of Jambi Bank Branch Sungai Penuh that in order to increase the level of customer loyalty future, it is recommended to enhancing banking image, customer satisfaction as well as service quality.
Specific Sindbis virus-coded function for minus-strand RNA synthesis

The synthesis of minus-strand RNA was studied in cell cultures infected with the heat-resistant strain of Sindbis virus and with temperature-sensitive (ts) belonging to complementation groups A, B, F, and G, all of which exhibited an RNA-negative (RNA-) phenotype when infection was initiated and maintained at 39 degrees C, the nonpermissive temperature. When infected cultures were shifted from 28 degrees C (the permissive temperature) to 39 degrees C at 3 h postinfection, the synthesis of viral minus-strand RNA ceased in cultures infected with ts mutants of complementation groups B and F, but continued in cultures infected with the parental virus and mutans of complementation groups A and G. In cultures infected with ts11 of complementation group B, the synthesis of viral minus-strand RNA ceased, whereas the synthesis of 42S and 26S plus-strand RNAs continued for at least 5 h after the shift to 39 degrees C. However, when ts11-infected cultures were returned to 28 degrees C 1 h after the shift to 39 degrees C, the synthesis of viral minus-strand RNA resumed, and the rate of viral RNA synthesis increased. The recovery of minus-strand synthesis translation of new proteins. We conclude that at least one viral function is required for alphavirus minus-strand synthesis that is not required for plus-strand synthesis. In cultures infected with ts6 of complementation group F, the syntheses of both viral plus-strand and minus-strand RNAs were drastically reduced after the shift to 39 degrees C. Since ts6 failed to synthesize both plus-strand and minus-strand RNAs after the shift to 39 degrees C, at least one common viral component appears to be required for the synthesis of both minus-strand and plus-strand RNAs.
Blood gas calculator.

SEVERINGHAUS, JOHN W. Blood gas calculator. J. Appl. Physiol. 21(3): I 108-1 I 16. 1966. -A slide rule is described whose scales yield direct solutions of the following blood gas problems: r) the whole blood oxygen dissociation curve of man with variable temperature, pH, and base excess; 2) the effect of anaerobic temperature change on blood Pea , Pcoz , and pH; 3) the true oxygen consumption fraction from mixed expired 02 and CO2 concentrations, breathing air; 4) correction of gas volume from ATPS to BTPS or STPD; 5) Henderson-Hasselbalch equation, relating pH, Pcoa , and either HC03 or CO2 content of plasma (range 10-40 C) or cerebrospinal fluid (20-40 C); 6) base excess and standard pH and bicarbonate (at Pcoz = 40 mm Hg) from pH and PCO~ at 37 C. The following modifications of standard blood gas relationships are described. The new oxygen dissociation curve deviates maximally from Dill’s curve by -4.5 and + I . 5 % at I 4 and 60 mm Hg PO:! , respectively. Temperature shifts the dissociation curve by A log PO:! 0.024 AT C (formerly about 0.019). The “Bohr shift” with l;ctic acid is about 20% less than with CO2 , the combined effect being given by A log POT = -0.48 A pH + . oo13 A base. The correction factors for anaerobic temperature change diminish for PO:! at high saturation and for pH in acidosis.
The Current Status of mHealth for Diabetes: Will it Be the Next Big Thing?

mHealth is an emerging concept in health care and uses mobile communications devices for health services and information. Mobile phones, patient monitoring devices, tablets, personal digital assistants, and other wireless devices can be part of mHealth systems. With mHealth systems, glucose data can now be automatically collected, transmitted, aggregated with other physiologic data, analyzed, stored, and presented as actionable information. mHealth systems use mobile decision support software applications (or apps) to assist or direct health care professionals to make decisions, or they can assist or direct patients to make decisions without waiting for input from a clinician. With real-time decision support for patients, appropriate actions can be taken in real time without waiting to see a clinician. Decisions can be personalized if individual treatment goals and personal preferences for treatment are inputted into an app. Few mHealth apps for diabetes have been rigorously tested. Outcome studies of the use of mHealth for diabetes from the literature have shown the potential for benefits, but higher-quality studies are needed. Regulatory approval of mHealth products will require demonstration of safety and effectiveness, especially where information and trends are not just presented to patients, but used to make treatment recommendations. Three additional hurdles must be overcome to facilitate widespread adoption of this technology, including demonstration of the following: (1) privacy to satisfy regulators, (2) clinical benefit to satisfy clinicians, and (3) economic benefit to satisfy payers. mHealth for diabetes is making rapid strides and is expected to be a transforming technology that will be the next big thing.
Evaluation of Current Technology Enabling E-Commerce in Zimbabwe

The growth of the internet as a viable business vehicle for conducting business transactions is one of the phenomena of modern information technology and has already had a significant impact on the business community, providing new methods of conducting business on a global basis (Jutla et al, 1999). E-commerce adds to the transparency and convinience of doing business and creates a level playing field. This study sought to analyse current technology enabling e-commerce. The study described and explained the diverse types of ecommerce technologies used in Zimbabwe. The study also came up with most common barriers and benefits of using e-commerce technology as well as the usage level of these technologies in Zimbabwe. The world wide web was discovered to be the mostly used e-commerce technology in Zimbabwe.The study recommended companies to adopt the current technology enabling e-commerce so that they can be globally competitive.
Correlating Micro-CT Imaging with Quantitative Histology

Advanced biomechanical models of biological tissues should be based on statistical morphometry of tissue architecture. A quantitative description of the microscopic properties of real tissue samples is an advantage when devising computer models that are statistically similar to biological tissues in physiological or pathological conditions. The recent development of X-ray microtomography (micro-CT) has introduced resolution similar to that of routine histology. The aim of this chapter is to review and discuss both automatic image processing and interactive, unbiased stereological tools available for micro-CT scans and histological micrographs. We will demonstrate the practical usability of micro-CT in two different types of three-dimensional (3-D) ex vivo samples: (i) bone scaffolds used in tissue engineering and (ii) microvascular corrosion casts.
Design and implementation of a shared buffer architecture for a gigabit Ethernet packet switch

In this paper, the authors explored the design issues of shared buffer architecture capable of buffering fixed and variable sized packets for a 10G Ethernet switch. The design and implementation of a shared buffer circuit based on Xilinx Virtex 4 FPGA technology was presented. The proposed architecture is economic from the resource sharing point of view and is capable of supporting buffer bandwidths in excess of 31 Gbps using standard FPGA technology.
Detrimental effects of beta-blockers in COPD: a concern for nonselective beta-blockers.

INTRODUCTION beta-Blockers are known to worsen FEV(1) and airway hyperresponsiveness (AHR) in patients with asthma. Both characteristics determine the outcome of COPD, a disease with frequent cardiac comorbidity requiring beta-blocker treatment. OBJECTIVE To determine the effects of beta-blockers on AHR (provocative concentration of methacholine causing a 20% fall in FEV(1) [PC(20)]), FEV(1), and response to formoterol in patients with COPD. DESIGN A double-blind, placebo-controlled, randomized, cross-over study. SETTING An ambulatory, hospital outpatient clinic of pulmonary diseases. PATIENTS Patients with mild-to-moderate irreversible COPD and AHR. INTERVENTION Fifteen patients received propranolol (80 mg), metoprolol (100 mg), celiprolol (200 mg), or placebo for 4 days, followed by a washout period >/= 3 days. On day 4 of treatment, FEV(1) and PC(20) were assessed. Immediately hereafter, formoterol (12 microg) was administered and FEV(1) was measured for up to 30 min. RESULTS PC(20) was significantly lower (p < 0.01) with propranolol and metoprolol treatment (geometric means, 2.06 mg/mL and 2.02 mg/mL, respectively) than with placebo (3.16 mg/mL) or celiprolol (3.41 mg/mL). FEV(1) deteriorated only after propranolol treatment (2.08 +/- 0.31 L) [mean +/- SD] compared with placebo (2.24 +/- 0.37 L). The fast bronchodilating effect of formoterol was hampered by propranolol (mean increase in FEV(1) at 3 min, 6.7 +/- 8.9%) but was unaffected by the other beta-blockers (16.9 +/- 9.8%, 22 +/- 11.6%, and 16.9 +/- 9.0% for placebo, metoprolol, and celiprolol, respectively). CONCLUSIONS Pulmonary effects did not occur by celiprolol. Only propranolol reduced FEV(1) and the bronchodilating effect of formoterol. Both metoprolol and propranolol increased AHR. Thus, different classes of beta-blockers have different pulmonary effects. The anticipated beneficial cardiovascular effects of a beta-blocker must be weighted against the putative detrimental pulmonary effects, ie, effect on FEV(1), AHR, and response to additional beta(2)-agonists.
Service Level Comparison for Online Shopping using Data Mining

- The term knowledge discovery in databases (KDD) is the analysis step of data mining. The data mining goal is to extract the knowledge and patterns from large data sets, not the data extraction itself. Big-Data Computing is a critical challenge for the ICT industry. Engineers and researchers are dealing with the cloud computing paradigm of petabyte data sets. Thus the demand for building a service stack to distribute, manage and process massive data sets has risen drastically. We investigate the problem for a single source node to broadcast the big chunk of data sets to a set of nodes to minimize the maximum completion time. These nodes may locate in the same datacenter or across geo-distributed data centers. The Big-data broadcasting problem is modeled into a LockStep Broadcast Tree (LSBT) problem. And the main idea of the LSBT is defining a basic unit of upload bandwidth, r, a node with capacity c broadcasts data to a set of [c=r] children at the rate r. Note that r is a parameter to be optimized as part of the LSBT problem. The broadcast data are further divided into m chunks. In a pipeline manner, these m chunks can then be broadcast down the LSBT. In a homogeneous network environment in which each node has the same upload capacity c, the optimal uplink rate r, of LSBT is either c=2 or 3, whichever gives the smaller maximum completion time. For heterogeneous environments, an O(nlog2n) algorithm is presented to select an optimal uplink rate r, and to construct an optimal LSBT. With lower computational complexity and low maximum completion time, the numerical results shows better performance.The methodology includes Various Web applications Building and Broadcasting followed by the Gateway Application and Batch Processing over the TSV Data after which the Web Crawling for Resources and MapReduce process takes place and finally Picking Products from Recommendations and Purchasing it.
On-Chip Millimeter-Wave Cold-Source Noise Figure Measurements With PNA-X

This paper addresses the extension of the on-chip cold-source noise figure (NF) measurement methodology to millimeter-wave (mm-wave) integrated circuits by using the PNA-X. The proposed methodology has been successfully applied to the on-chip NF measurements of mm-wave building blocks on silicon such as a 4-b programmable 16-phase active phase shifter. The results show how the cold-source method can be extended up to the mm-wave frequency range by using the PNA-X with frequency extenders and an active frequency down-converter, so allowing satisfactory NF measurements of mm-wave integrated circuits.