Miracle-dz/UniFAR-FTUs huggingface dataset:
A Study of Observation in Treatment Modality of Acute and Chronic Poisoning Cases by Analysing Clinical Laboratory Parameters and its Outcome in Tertiary Care Hospitals

The Present Study BACKGROUND: Poisoning cases is a significant contributor to morbidity and mortality all over the world. Acute poisoning cases are the most common causes of emergency hospitalization. Poisoning cases were mainly diagnosed by victims from patients and biochemical, hematological test and also using the qualitative and quantitative analytical techniques in the toxicology department. PATIENTS & METHODS: The study was conducted at Govt. Head Quarters Hospital Tirupur-642206, Govt. Head Quarters Hospital Erode-638112, Dhenvendhri Critical Care Hospital, karungal palayam Erode-638003. It was a retrospective observational study, observation were made on the basis of patient’s histories such as age, sex, mode of poisoning, nature of poisoning, diagnosis method used for the identification of compound, and treatment given to the patients. RESULT AND ANALYSIS: From this retrospective study was observed that, there is an alarming increase of poisoning cases is mainly for suicidal purpose (69%). Agricultural poisons were found to be the most common causes of acute poisoning cases (55%). The major number of poisonings cases are reported in the young people’s age range (26-35 years old) (35%) and followed by the peoples age range (15-25years old) (22%). Males were the major victims in overall poisoning cases (61%) and the most poisoning cases were from rural area than the urban area. CONCLUSION: Agricultural poisons was found to be the most common causes of acute poisoning, Aluminum Phosphate, Monochrotophos, Zinc Phosphate, Snake bite, Oleander poisoning, Cow Dung Powder poisoning were the most common causes of acute poisoning. Most of the treatments were provided to the patients according to symptomatic treatment only, based on the evidence or sample of poisons brought with patients.
CHARACTERIZATION OF METRONIDAZOLE- AND VANCOMYCIN-RESISTANT CLINICAL ISOLATES OF CLOSTRIDIUM DIFFICILE

The incidence of C. difficile infections (CDI) has been increasing at an alarming rate. This was precipitated by the emergence of strains with increased virulence, disease severity, and high recurrence rates. These strains also exhibit high propensity for resistance to antibiotics such as fluoroquinolones and beta lactams, which has made the treatment of CDI very challenging. Currently, metronidazole and vancomycin are the most commonly used drugs for the treatment of primary CDI. Metronidazole is used for the treatment of mild to non-severe cases of CDI while vancomycin is reserved for severe CDI cases. In 25-30% of the patients treated with these antibiotics, the infection may recur, and this further complicates CDI treatment. Because C. difficile strains have an intrinsic ability to resist multiple antibiotics, it was hypothesized that there may be strains with high resistance to metronidazole and vancomycin circulating in the patient population. To investigate this hypothesis, 536 clinical CDI stool samples obtained from patients who presented with diarrhea at St. Luke’s Episcopal Hospital at the Texas Medical Center Houston, Texas, Kenyatta National Hospital, Nairobi, and Kisii Teaching and Referral Hospital, Kisii, Kenya were screened for resistant C. difficile strains. The stool samples were analyzed on C. difficile-specific differential medium containing either metronidazole (8 μg/ml) or vancomycin (4 μg/ml). These are concentrations designated by the Clinical
Navigating the World of Alzheimer's Disease: An Educational Guide for Family Members

Alzheimer's Disease (AD) is a condition which deteriorates the brain and results in a form of dementia. Its the sixth leading cause of death in the U.S. and its symptoms have significant impact on both individual with AD and their caregivers. Family members are often confused and overwhelmed with an AD diagnosis. This thesis incorporates a comprehensive literature review that addresses four significant areas of need for individuals with AD: Feeding, communication, behavioral, and activities of daily life. The booklet highlight the importance of family education as they navigate the unfamiliar road of AD. Degree Type Open Access Senior Honors Thesis Department Special Education First Advisor Ana Claudia Harten Second Advisor Ana Claudia Harten Third Advisor David C. Winters
Corruption

Chapter 13 examines the problem of corruption in Classical Athens. There are numerous references to corruption in Demosthenes, Attic oratory, and Greek literature. In an Athenian context, corruption typically involved the bribery of prominent officials. A central issue is ‘katapolitical’ bribery, or bribery at the expense of public interests or with intention to damage institutions or the community. The article considers the institutional and legal regulations adopted by Athens to combat bribery as well as the range of penalties and procedures against offenders, including prosecution. It also discusses the case of Aeschines, who was prosecuted by Demosthenes in his speech On the False Embassy (Dem. 19; Aeschin. 2) for mismanagement on the second embassy (parapresbeia) in support of the Peace of Philocrates in 346.
Guideline for the treatment of patients with acute stress disorder and posttraumatic stress disorder

as well as other interested individuals and organizations (see p. 45) and two members of the editorial board of The American Journal of Psychiatry. Approved by the APA Board of Trustees in June 2004 and published in November 2004. Part A received by The American Journal of Psychiatry June 30, 2004; accepted July 16, 2004. Copyright © 2004 American Psychiatric Association. ALL RIGHTS RESERVED. No part of this Practice Guideline may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, or by any information storage or retrieval system, without permission in writing from the publisher. American Psychiatric Association Practice Guidelines
Nursing bedside clinical handover: A pilot study testing a ward-based education intervention to improve patient outcomes

Objective: To explore the effectiveness of an education intervention in facilitating the provision of standardised bedside nursing handover communication, and enhancement of patient safety and quality of care in geriatric and rehabilitation wards. Design: Pilot study using a prospective before and after quasi-experimental design. Setting: Two geriatric and rehabilitation wards of a major tertiary referral teaching and research hospital in Brisbane, Australia. Participants: The study population was comprised of registered and enrolled nurses employed in the two wards, and all inpatients and their families present in the two wards at the time of the study. Main outcome measures: The outcome measures included patient outcomes (patient satisfaction with the bedside handover process, the number of patient adverse events); and staff outcomes (staff satisfaction with the bedside handover process, compliance with best-practice nursing shiftto- shift handover recommendations). Results: A total of 104 bedside handover audits were completed. Of the 143 patients admitted to the two wards, 125 met the inclusion criteria. Returned satisfaction surveys were received from 105 patients. Of the 58 nursing staff who met the inclusion criteria, 93% returned the satisfaction surveys before implementation and 58.6% returned the satisfaction surveys after implementation. Results showed improved nursing compliance with best practice shift-to-shift handover, and increased patient and nursing staff satisfaction with the bedside handover process. Reduction in the number and severity of patient adverse events was noted: 9.37% decrease in the number of falls without patient harm, 75% decrease in the number of pressure injuries, and 11.1% decrease in medication errors. Conclusion: The results indicate that nursing education had a positive impact on the quality of the communication during bedside nursing clinical handover in the two geriatric and rehabilitation wards.
A Pilot Study Evaluation of a Web‐Based Token Economy to Increase Adherence with a Community‐Based Exercise Intervention in Child and Adolescent Cancer Survivors

&NA; The present pilot study aimed to evaluate the efficacy of an online token economy to increase childhood cancer survivors' adherence with a 6‐week exercise intervention. Secondary aims assessed intervention efficacy. Childhood cancer survivors aged 6‐18 who were one year off treatment were enrolled in the intervention. Participants completed pre‐post measures of endurance, strength, functional mobility, and quality of life. During weekly sessions, adherence was assessed by having the child perform progressively more complex physical skills. Home adherence was measured through web‐based exercise logs. Participants earned “chips” for adherence with the exercise program. Twelve survivors completed the intervention. Compliance was variable across intervention behaviors. Intervention efficacy was demonstrated through significant changes in endurance, strength, and functional mobility. Findings support the use of an online token economy system to increase adherence with the exercise intervention in some settings. Future studies should consider the role of social support in survivors' engagement in physical activity.
Combination of Metformin and Chemotherapy Decreases the Recurrence Rates of Epithelial Ovarian Cancers: A Randomized Clinical Trial

Background: The mainstay of treatment for ovarian cancers is surgical resection and post-operative chemotherapy to minimize the chance for recurrence. Metformin has been evidenced to increase the cytotoxic effects of chemotherapy in malignant cells and tissues by altering several gene expression pathways. Objectives: This study evaluated clinical efficacy of adding metformin to chemotherapy regimen for patients with ovarian cancers. Methods: The patients were divided in two groups; the study group received 500 mg metformin 3 times a day in addition to standard chemotherapy sessions after surgical resection of the primary ovarian cancer. The control group received only the standard chemotherapeutic agents after surgery. The patients were followed for up to 4 years and recurrence rate and their disease free survival after surgical resection statistically were compared between two groups. Results: The recurrence of the primary malignancy occurred in 13.3% of the study cases versus 67.5% in control group. Disease free survival was 48 months in the study group, which was significantly longer than the control group (25.7 months). Conclusions: The results of this study demonstrate that adding metformin to the chemotherapy regimen of patients undergoing surgery for ovarian cancer can clinically improve the outcome of treatment by decreasing the overall rate of recurrence and prolonging the disease free survival in these patients.
Ratlarda Deneysel Olarak Oluşturulan Yara Modelinde Civanperçemi (Achillea millefolium) Bitkisinin Yara İyileşmesi ve Oksidatif Stres Üzerine Etkisinin Histopatolojik ve Biyokimyasal Olarak Araştırılması

Bu calismada Civanpercemi’nin ( Achillea millefolium) (CP) ratlarda yara iyilesmesi uzerine histopatolojik ve biyokimyasal etkisi arastirildi. Calismada 24 adet Wistar albino irki rat kullanildi. Ratlar; Kontrol (K), CP ve Madecassol (M) grubu olmak uzere uc gruba ayrildi. Tum gruplardaki ratlarin sirt bolgesi derisinde anestezi altinda punch cihazi ile yara olusturuldu. CP grubu ratlarin yara bolgelerine CP ekstraktindan elde edilen pomat uygulanirken, M grubu ratlarin yara bolgelerine ise ticari bir preparat olan madecassol kremi uygulandi. Denemenin 7. gunu ile deneme sonu olan 15. gunde anestezi altinda kan ve deri doku ornekleri alindi. Histopatolojik incelemelerde, K grubu ile karsilastirildiginda CP grubunda yangi ve odemin azaldigi, epitelizasyon, fibroblastik aktivite ve kollajenizayonda pozitif bir etki goruldu. Immunohistokimyasal olarak CP grubunda Glutathione peroxidase 1 (GPx1) immunoreaktivitesi K grubundan daha guclu idi. Deri ve kan dokusunun biyokimyasal incelemelerinde K grubuna gore M ve CP grubunda antioksidan savunma sistemi enzim duzeyleri daha yuksek idi. Sonuc olarak CP’ nin bag doku olusumunu arttirdigi ve epitelizasyonun tamamlanmasi icin gerekli zamani azalttigi, bu vesile ile yara iyilesmesini hizlandirdigi gorulmustur.
Analysis of histological frequency and pediatric cancer in Rondônia, Western Amazonia (Brazil)

Objective:Describe the histological and cancer frequency in children and adolescents attended at the Hospital de Base Dr. Ary Pinheiro and the Hospital de Barretos / Rondonia, Western Amazonia, in the years 2014 and 2015. Method: This is a descriptive, quantitative and transverse study. We used a structured instrument containing a series of variables, such as gender, age, histological types, more frequent neoplasms, lymphomas, leukemias, among others. We asked The Comite de Etica em Pesquisa em Seres Humanos (Research Ethics Committee) to dispense the Informed Consent Form because the study did not require intervention on the patient or collection of biological material, and no possibility of constraints on patients and their relatives. Results: From 75 cases, 32 (42.7%) were female and 43 (57.3%) were male. Regarding the distribution of patients according to the age group, 21 (28.0%) were younger than 4 years, 12 (16.0%), 5 to 9 years, 17 (22.6%) from 10 to 14 and 25 (33.4%) from 15 to 19. The most frequent histological types by gender were leukemias of myeloproliferative diseases and myelodysplastic diseases with 30% and 50% new cases in the period, followed by lymphomas and reticuloendothelial neoplasms with 16.65% and 20, 0% of the histological types in the period. Leukemia in the hematopoietic and reticuloendothelial system (C42) is the most frequent cancer in both, female and male gender, with 47.5% of cancers in the biennium. The second group of cancers in children from 0 to 19 years old and location of the primary tumor is the encephalon carcinoma (C71), with 11.25% of the new cases. Conclusions: The results presented with their proper nuances are in agreement with the data of studies carried out in Brazil and in other countries.
Synergism of PDL/PD1 and IL33/ST2 Axis in Tumor Immunology

Abstract When it comes to tumor immunology, understanding of molecular pathways is rather important. During oncogenesis, many molecules should be taken in consideration altogether in context of a single malignancy. It is of a great significance to determine whether these molecules act synergistically or contrary, whether to understand a malignant disease more thoroughly, or even more important, to reveal new approaches of therapy. In this review, we discuss whether and how IL-33/ST2 and PD-1/PDL axis involve in antitumor immunity.
Experiencia con videocápsula endoscópica en el estudio y diagnóstico de enfermedades del intestino delgado en un hospital de alta complejidad en Medellín, Colombia

Introducción: el intestino delgado (ID) es un órgano difícil de estudiar debido a su gran tamaño y ubicación anatómica; los estudios endoscópicos convencionales (esofagogastroduodenoscopia y colonoscopia) no logran evaluarlo en su totalidad y la enteroscopia con balón es más invasiva, con mayores efectos adversos y tasas de complicaciones. La videocápsula endoscópica (VCE) es una tecnología mínimamente invasiva que permite visualizar de forma dinámica y completa la mucosa del ID; es el método directo más seguro y con menos tasas de complicaciones. Metodología: se realizó un estudio descriptivo de corte transversal, para describir la experiencia clínica en la utilización de la VCE en un hospital de alta complejidad en Medellín, Colombia; asimismo, determinar las indicaciones, síntomas más comunes y hallazgos anormales.Resultados: se realizaron 374 VCE en el período de estudio: 282 ambulatorias (75,4 %) y 92 hospitalizados (24,6 %). En ambos grupos la indicación más frecuente fue sangrado digestivo oscuro (38,65 % y 53,26 %, respectivamente), seguidos por anemia crónica en el 27,65 % de ambulatorios y por enfermedad inflamatoria intestinal (EII) en 21,74 % de los hospitalizados. Los hallazgos anormales fueron más frecuentes en el yeyuno y las lesiones más comunes fueron angiodisplasias y lesiones inflamatorias.Conclusiones: en las indicaciones más frecuentes (sangrado digestivo oscuro y anemia) se documentaron potenciales fuentes de sangrado en más del 70 % de los casos; siendo las lesiones vasculares e inflamatorias los hallazgos más comunes. En seguimiento o evaluación de EII se documentaron en más del 50 % lesiones inflamatorias. La VCE es muy segura, no se presentó ninguna complicación relacionada con la VCE.
Why should we switch chest compression providers every 2 minutes during cardiopulmonary resuscitation

Objective. This study was conducted to determine whether trained male rescuers could maintain adequate chest compres-sion depth (CCD) for longer than the cur-rent recommended guidelines of 2 minutes. Methods. Forty male medical doctors ad-ministered a 5-minute single rescuer car-diopulmonary resuscitation (CPR) to a manikin on the floor with conventional CPR or randomly administered continu-ous chest compressions (CCC). The ratio of compression to ventilation was set to 30:2 with mouth-to-mouth technique dur-ing conventional CPR. Chest compression data were recorded with an accelerometer device and divided into 1-minute segments for analysis.Results. Although average CCD main-tained the recommended depths through-out 5 minutes in conventional CPR, it de-creased significantly with CCC (1 minute: 55.4 ± 4.5 mm; 2 minutes: 54.2 ± 5.4 mm; 3 minutes: 52.6 ± 5.6 mm; 4 minutes: 51.6 ± 5.5 mm; 5 minutes: 49.9 ± 5.8 mm, p < 0.001). The average chest compression numbers (ACCN) per minute were main-tained over 80/min and have not been changed significantly within 5 minutes in the CCC. However, it didn’t reach to the 80/min and decreased significantly after 3minutes compared to the baseline ACCN during first 1-minute segment in the con-ventional CPR.Conclusions. Despite the chest compres-sion providers being limited to trained male medical doctors, the average CCD decreased significantly within 5minutes with CCC. Although maintaining adequate CCD, ACCN in each minute decreased sig-nificantly after 3minutes in the conventional CPR. Therefore, we should rotate chest compression providers every 2minutes re-gardless of the rescuer’s qualifications and CPR methods.
Primary ovarian insufficiency and fertility preservation: review article

Introduction: Female fertility and the ovarian reserve decrease with age. Material and methods: Review of literature about the primary ovarian insufficiency (POI) and methods of fertility preservation to define women at risk of POI and their fertility saving options. Results: Women with a family history of POI, fragile X syndrome primary ovarian insufficiency mutation (FXPOI), autoimmune thyroiditis, Addison’s disease, exposure to toxins and viral infection are at high risk of POI. In-vitro-fertilization success improved after introduction of oocyte (or embryo) vitrification. Transplantation of the cryo-preserved ovarian tissue could be a fertility preservation option. Transplantation of the cryo-preserved ovarian tissue is an outpatient procedure, which restores hormonal function and fertility. After ovarian tissue transplantation women can conceive normally without medical assistance. Conclusions: The use of donor oocytes is the only treatment for women at risk of POI. The in-vitro-fertilization outcome improved after introduction of oocyte (or embryo) vitrification. Transplantation of the cryo-preserved ovarian tissue is an outpatient procedure, which restores hormonal function and fertility.
The Effect of Eight Weeks Concurrent Training and Supplementation of L_Arginine on Stress Oxidative and Lipid Profile in Elderly Men

Aims: One of the strategies for coping with oxidative stress and, subsequently, prevention complication of aging is the use of antioxidant supplements and exercise training. Therefore the aim of this study was to evaluate concurrent training and supplementation of L-arginine on stress oxidative and lipid profile in elderly men. Materials & Methods: In this quasi experimental study, 44 older volunteering men (mean age: 67.77± 4.61), were selected by simple convenience sampling from Isfahan city in 2017 and by using NCSS PASS 11 software, they were randomly divided into four equal-sized groups (each n=11): Concurrent Training +Supplement (ES) group; Concurrent Training +Placebo (EP) group; Supplement (S) group and Control (C) group. The ES and EP groups performed the exercise protocol with eight weeks of concurrent training, three sessions per week. Group ES and group S consumed 1000 mg of L-Arginine every morning and one hour before the exercise. Maltodextrin were used as placebo. Biochemical samples were assayed by ELISA method and multivariate longitudinal model were used for analysis of data in the level of significance p<0.05. Findings: Results showed that, joint effect of training and supplementation was more than the effect of the exercise or supplement alone on variable of stress oxidative 8-OhdG (β=-5.16, p<0.001), TAC (β=-2.30, p<0.001), and MDA (β=3.50, p<0.001) and variables lipid profile LDL (β=-20.82, p<0.001), VLDL (β=-4.73, p<0.001), HDL (β=-3.81, p<0.022), TC (β=-21.15, p<0.001), TG (β=-24.74, p<0.001). Conclusion: Findings of this study suggest that the simultaneous use of concurrent training and supplementation of L-Arginine improves the system antioxidant and lipid profile in the
Prototypical Implementation of a Decision-supporting System for Operative Breast Cancer Therapy

: Based on the current edition of the German guideline on Screening, Diagnosis, Treatment and Follow-up of breast cancer, we created a patient journey modelled in BPMN (Business Process Model and Notation V2) serving as template for the development of a patient centered decision support system. This approach resulted in two prototypical devices represented by a web-based information platform and a mobile application, intended to support the decision support at the point of care. These early prototypes were discussed with a clinical expert and the members of a regional breast cancer self-help group. The information gained by this approach will be integrated in the further user centered design of the devices.
Drainage autogène (DA) versus Expiration Lente et Totale Glotte ouverte (ELTGOL) pour le désencombrement bronchique des patients atteints de mucoviscidose

La technique de DA a ete concue pour le desencombrement bronchique des patients atteints de mucoviscidose. Elle est consideree comme la technique de reference, et son efficacite a ete montree au cours de nombreuses etudes. L’ELTGOL est simple d’utilisation et favorise la deflation pulmonaire et donc le desencombrement bronchique, mais cette technique a ete peu investiguee dans le contexte de la mucoviscidose. Pourtant les deux techniques reposent sur le meme principe physiologique de l’expiration lente et sont praticables de maniere autonome, elles s’adressent donc a des patients atteints de maladies chroniques. Nous avons choisi de comparer les effets a court terme de l’ELTGOL et du DA dans la prise en charge des patients atteints de mucoviscidose. « La technique ELTGOL est-elle plus efficace que le DA pour le desencombrement bronchique des patients atteints de mucoviscidose ? » Cette etude en cross over de 5 semaines inclus 5 patients adultes hors exacerbation atteints de mucoviscidose. Ils sont randomises en 2 groupes. Pendant les deux premieres semaines, le groupe 1 recoit le DA pendant que le groupe 2 pratique l’ELTGOL, et les 2 dernieres semaines les 2 groupes inversent les techniques. Les parametres evalues sont la fonction pulmonaire, l’irritabilite bronchique, le cout ventilatoire, la qualite de vie et la preference. Il n’y a pas de difference majeure entre le DA et l’ELTGOL concernant les criteres evalues. L’ELTGOL semble etre aussi performante que le DA pour le desencombrement bronchique des patients atteints de mucoviscidose, mais des etudes de plus forte puissance sont necessaires pour le montrer.