Miracle-dz/UniFAR-FTUs huggingface dataset:
Les anomalies de la fréquence fondamentale chez le locuteur Parkinsonien : contraste entre les effets respectifs de l'hypodopaminergie dûe à la maladie de Parkinson et de l'apport thérapeutique par L-Dopa

Objectif : les troubles de la voix et de la parole sont frequents dans la maladie de Parkinson (MDP), en particulier lorsque la maladie est installee depuis plusieurs annees. Ces troubles ont un impact sur la communication parlee, ce qui peut entrainer un handicap important pour les personnes qui en souffrent. De nombreuses etudes s'appuyant sur des methodes perceptives ou acoustiques ont ete menees pour tenter de caracteriser cette dysarthrie parkinsonienne. Or, l'heterogeneite des methodes d'evaluation et les biais experimentaux aboutissent a des resultats difficiles a interpreter. Dans le cadre de notre etude, nous nous interessons specifiquement aux troubles phonatoires et particulierement a la frequence fondamentale (F0). Or, la litterature laisse apparaitre des resultats contradictoires : elevation, baisse ou pas de difference de F0 dans la MDP par rapport a une population de sujets controle. L'objet de ce travail est donc de fournir un cadre conceptuel et methodologique permettant d'expliquer les resultats obtenus sur la F0 moyenne de locuteurs MDP. Methode : le corpus de l'etude est constitue de 44 locuteurs (29 patients MDP et 15 sujets temoins) en controlant des contraintes physiologiques (sexe, âge, etat pharmacologique des patients) et linguistiques (tâches de production de parole). Resultats : sur ce corpus, nous n'avons pas observe de difference de F0 moyenne entre les patients MDP sans medicament antiparkinsonien et la population controle. En revanche, une augmentation significative a ete mise en evidence lors de la prise de L-dopa. Conclusion : nous emettons l'hypothese d'un double effet oppose sur la F0 dans la situation de sevrage medicamenteux. La pression-sous glottique basse due a la MDP induit une diminution de F0 tandis que la rigidite laryngee entraine une elevation de F0, ces deux effets s'annihilent. En revanche, en situation de prise de L-dopa, l'effet medicamenteux restituant une pression-sous glottique plus elevee entraine donc, concomitant a l'augmentation de hauteur par rigidite, une hausse de la F0.
phenotools: An r package for visualizing and analysing phenomic datasets

Phenotypic data are crucial for understanding genotype–phenotype relationships, assessing the tree of life and revealing trends in trait diversity over time. Large‐scale description of whole organisms for quantitative analyses (phenomics) presents several challenges, and technological advances in the collection of genomic data outpace those for phenomic data. Reasons for this disparity include the time‐consuming and expensive nature of collecting discrete phenotypic data and mining previously published data on a given species (both often requiring anatomical expertise across taxa), and computational challenges involved with analysing high‐dimensional datasets. One approach to building approximations of organismal phenomes is to combine published datasets of discrete characters assembled for phylogenetic analyses into a phenomic dataset. Despite a wealth of legacy datasets in the literature for many groups, relatively few methods exist for automating the assembly, analysis, and visualization of phenomic datasets in phylogenetic contexts. Here, we introduce a new r package phenotools for integrating (fusing original or legacy datasets), curating (finding and removing duplicates) and visualizing phenomic datasets. We demonstrate the utility of the proposed toolkit with a morphological dataset for flightless birds and two morphological datasets for theropod dinosaurs and provide recommendations for character construction to maximize accessibility in future workflows. Visualization tools allow rapid identification of anatomical subregions with difficult or problematic histories of homology. We anticipate these tools aiding automation of the assembly and visualization of phenomic datasets to inform evolutionary relationships and rates of phenotypic evolution.
Seismic Effects on the Secular Drift of the Earth's Rotational Pole

Earthquake‐induced mass redistribution in the Earth excites the polar motion; its cumulative coseismic effect has been found to cause a secular polar drift (SPD) toward ~140°E longitude with strong statistical tendency. Here we find numerically the cumulatively coseismic effect in SPD since 1952 to be at the rate of ~0.75 mas/year (or ~2.3 cm/year), amounting to nearly 20% of the observed SPD that points to the opposite geographical direction and hence is significant in the pursuit of understanding the source budget of SPD. We further argue on theoretical and observational ground that such behavior reflects that of the overall plate tectonic motion and in fact accounts for a fraction of the latter over long term. The exact amount of the fraction is indeterminate until mass transport models of plate tectonics prove adequate. This viewpoint is in contrast to that of Cambiotti et al. (2016, https://doi.org/10.1093/gji/ggw077) which required the coseismic effect to get annihilated completely by the interseismic effect under their earthquake cycle decomposition of the velocity field at the faulting system.
Influence of flood dynamics on forest carbon stocks, litterfall seasonality and net primary productivity in amazonian várzea forests

Two macro-environments can be distinguished among Amazonian vegetation types: upland areas, predominantly forested and not susceptible to flooding, and wetland areas. The full extent of wetlands in the Amazon is about c.a. 30% of the Amazon basin, where floodplains comprise more than 25% of wetland areas. In the Amazon, the amplitude of seasonal water level variations can reach up to 16 m in Western Amazon, 10 m in Central Amazon, and 6 m in Eastern Amazon, with local flood extent and duration depending on the interaction among precipitation, river discharge and geomorphology. Ecological and environmental processes in floodplains are largely controlled by the flood pulse a theoretical concept which postulates that amplitude, duration, frequency and periodicity (predictability) of flood pulses are the major factor maintaining the dynamic environmental equilibrium in floodplains. Amazonian floodplains play an important role in the regional biogeochemical cycles and biodiversity maintenance, and provide important ecosystem services to human societies. However, these environments remain greatly overlooked regarding basin-scale estimates of biogeochemical cycles. Therefore, the present study aims to advance our understanding of how spatial heterogeneity in terms of different forest subtypes and flood patterns of várzea forests controls three key ecological aspects: carbon stocks, litterfall production and dynamics, and net primary productivity. Using multitemporal synthetic aperture radar (SAR) remote sensing imagery combined with field data, we derived vegetation structure and flood duration classes in the study area. We also developed an empirical flood modeling method based on logistic modeling to allow us to extend the current capabilities in predict spatial patterns of flooding. Then we explored how spatial heterogeneity drives patterns of aboveground carbon stocks using standard forest inventory methods. Monitoring one full year of litterfall, we asked how litter production and dynamics vary among distinct forest communities under different flood regimes and we also estimated net primary productivity and discussed how it varies in space.
Development of a chiral RP-HPLC method for identification of stereomers of newly synthesized xanthine-based hydrazide-hydrazone compound

A reversed phase enantio selective high performance liquid chromatographic method was developed for enantiomeric separation of 2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purine-7(6H)-yl)-N'-(3-fluorobenzylidene)-propanehydrazide isomers. The enantiomers of 2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purine-7(6H)-yl)-N'-(3-fluorobenzylidene)propanehydra-zide were resolved on a ACEÒEquivalenceTM С18 (250 × 4.6 mm, 5 μm) column using a mobile phase system containing methanol, water, phosphate buffer рН 7.4 (50:46:4 v/v/v). The resolution between enantiomers was found to be more than 2.0. The sample solution and mobile phase were found to be stable for at least 48 h. The final optimized method was successfully applied to separate the (R)- and the (S)-enantiomers of 2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purine-7(6H)-yl)-N'-(3-fluorobenzylidene)-propanehydrazide and was proven to be reproducible and accurate.
A Critical Review of Spatial Predictive Modeling Process in Environmental Sciences with Reproducible Examples in R

Spatial predictive methods are increasingly being used to generate predictions across various disciplines in environmental sciences. Accuracy of the predictions is critical as they form the basis for environmental management and conservation. Therefore, improving the accuracy by selecting an appropriate method and then developing the most accurate predictive model(s) is essential. However, it is challenging to select an appropriate method and find the most accurate predictive model for a given dataset due to many aspects and multiple factors involved in the modeling process. Many previous studies considered only a portion of these aspects and factors, often leading to sub-optimal or even misleading predictive models. This study evaluates a spatial predictive modeling process, and identifies nine major components for spatial predictive modeling. Each of these nine components is then reviewed, and guidelines for selecting and applying relevant components and developing accurate predictive models are provided. Finally, reproducible examples using spm, an R package, are provided to demonstrate how to select and develop predictive models using machine learning, geostatistics, and their hybrid methods according to predictive accuracy for spatial predictive modeling; reproducible examples are also provided to generate and visualize spatial predictions in environmental sciences.
Condicionador unificado de qualidade de energia com controle digital

Este trabalho apresenta um condicionador unificado de qualidade de energia (UPQC) controlado digitalmente. Tal condicionador e composto por um filtro ativo paralelo, para compensar a corrente na rede, e um filtro ativo serie, para compensara tensao na carga. A proposta consiste em aplicar uma estrategia de controle simples baseada na comparacao direta da corrente na rede e tensao na carga com referencias senoidas. Inicialmente e apresentado um estudo a respeito das topologias e classificacao dos condicionadores de energia, em seguida e explorada a estrutura de potencia do UFQC, como definicao do conversor, aspectos relacionados a conexao com a rede e anAlise e projeto dos filtros passivos. Posteriormente sao obtidos os modelos matematicos, projetados os controladores e elaboradas simulacoes para, finalmente apresentar os resultados obtidos com os ensaios do UPQC.
ANXA5 Enhances Malignancy of Murine Hepatocarcinoma Hca-P Cells via ERK Activation and E-cadherin Suppression

The invasion and metastasis are linked to the rapid progression and poor prognosis of hepatocarcinoma patients. Lymphatic metastasis is potentially involved in above pathogenesis with unclear mechanism. Previously, we found the deregulation of annexin A5 (ANXA5), a member of Ca2+-regulated phospholipid- and membrane-binding annexin family protein, mediated the in vivo malignancy, lymph node metastasis (LNM) rate and level of mice transplanted with Hca-P, a murine hepatocarcinoma cell line with the LNM potential rate of ~25%. Current work aimed to investigate the influence with action mechanism of ANXA5 overexpression on the in vitro malignant behaviours of Hca-P cells. For overexpressing ANXA5, the Anxa5 gene was ligated into pCDNA3.1 (+) vector and transfected into Hca-P named as Hca-P-ANXA5up. Hca-P transfected with empty pCDNA3.1 (+) vector was named as Hca-P-mock and used as the control. The monoclonal Hca-P-mock and Hca-P-ANXA5up cell lines were obtained against G418 screening using limiting dilution method. Compared with the Hca-P-mock cells, Western blotting assay indicated ANXA5 expression level was increased by 50.1% (p=0.025) in the Hca-P-ANXA5up cells. Transwell chamber assays indicated that the migration and invasion capacities of Hca-P-ANXA5up cells were increased by 150.2% (p=0.001) and 94.8% (p=0.003) than Hca-P-mock cells. ANXA5 overexpression enhanced the levels of p-MEK (Ser217/221), ERK1, ERK2, p-ERK1 (Thr202/Tyr204) and p-ERK2 (Thr185/Tyr187), and suppressed the levels of E-Cadherin, Snail and Slug in Hca-P cells. Current work shows ANXA5 overexpression enhances the malignant behaviours of hepatocarcinoma Hca-P cells through activating p-MEK-ERK pathway and suppressing E-Cadherin, Snail and Slug. It is of potential value in tumor malignancy and lymphatic metastasis of hepatocarcinoma.
THE EFFECT OF PARENTAL INFLUENCE AND THE DOPAMINE TRANSPORTER (DAT1) GENE ON EARLY ANTISOCIAL BEHAVIOR IN CHILDREN: DETERMINING RISK FOR DELINQUENCY USING A GxE

by Trevor A Gonzales This study examined the effect of negative maternal behaviors and the child’s dopamine transporter polymorphism on early signs of delinquency in children. Using data from the Fragile Families and Child Wellbeing Survey, conducted by Princeton University, the child’s DAT1 polymorphism will be examined and tested as part of a gene environment interaction (GxE) to determine a possible relationship between environments with exposure to negative maternal behaviors, and different DAT1 polymorphisms in the child, to predict early signs of delinquency. Four different maternal behaviors were examined; alcohol use, drug use, punishment of the child, and lack of maternal attachment. Each of these behaviors was examined along with the DAT1 gene of the child using two models for each variable. The first examined the behavior and gene independently, the second included a variable for a GxE between them. The GxEs between the maternal behaviors and the DAT1 genes did not have a significant impact on delinquency in any of the tests. Maternal drug use, punishment of the child, and child’s lack of attachment to mother were all significantly related to increased delinquency. THE EFFECT OF PARENTAL INFLUENCE AND THE DOPAMINE TRANSPORTER (DAT1) GENE ON EARLY ANTISOCIAL BEHAVIOR IN CHILDREN: DETERMINING RISK FOR DELINQUENCY USING A GxE by Trevor A Gonzales A Thesis presented in partial fulfillment of the requirements for the degree of Master of Science in the Department of Criminal Justice University of Central Missouri August, 2018 THE EFFECT OF PARENTAL INFLUENCE AND THE DOPAMINE TRANSPORTER (DAT1) GENE ON EARLY ANTISOCIAL BEHAVIOR IN CHILDREN: DETERMINING RISK FOR DELINQUENCY USING A GxE by Trevor A Gonzales
AKUNTANSI DALAM RUMAH TANGGA:STUDI FENOMENOLOGI PADAAKUNTAN DAN NON AKUNTAN

Tugas akhir ini bertujuan untuk memahami pengalaman beberapa individu atau pasangan dalam rumah tangga dalam mengelola keuangan dengan mempraktikkan akuntansi dalam rumah tangga. Penelitian ini dilakukan dengan pendekatan kualitatif dimana aspek-aspek akuntansi yang diinvestigasi adalah motivasi, manfaat dan nilai-nilai yang lahir dalam praktik akuntansi rumah tangga serta penganggaran, pencatatan, pengambilan keputusan dan perencanaan keuangan jangka panjang. Data penelitan dikumpulkan melalui serangkaian wawancara semi terstrukstur. Adapun Informan yang dijadikan objek dalam penelitian ini merupakan pasangan rumah tangga yang berprofesi sebagai akuntan dan non akuntan. Lebih lanjut temuan penelitian dianalisis dengan pendekatan analisis tema, dengan mental accounting sebagai kerangka teori. Hasil penelitian menunjukkan bahwa praktik akuntansi dalam rumah tangga keluarga akuntan dan non akuntan bervariasi dimana tidak hanya dilatarbelakangi oleh pendidikan namun juga disebabkan oleh status pekerjaan, unsur geografis dan mental yang dimiliki oleh pasangan dalam mempraktikkan akuntansi dalam rumah tangga. Implikasi dari penelitian ini diharapkan menjadi acuan awal bagi pasangan rumah tangga dalam mengelola keuangan rumah tangga. Kata kunci: Akuntansi Rumah Tangga, Fenomenologi, Mental accounting, Akuntan dan Non Akuntan
The art of marine science: collaborating with art students to create outreach and education tools on ocean acidification in the Florida Keys: Final report

Ocean acidification and climate change research is beginning to make significant progress, but raises challenges for effectively communicating new findings to the public. Mote Marine Laboratory (MML) scientists have already begun working on this complex ecological issue in relation to the Florida Keys and are putting together new ways to ensure the information is received by the public. Groffman et al. (2010) have shown that scientists need to engage audiences in new ways, other than simple brochures or lectures. This includes involving people outside of the science realm, such as artists, who have skill sets where scientists aren’t typically trained. Artists are very creative and often present ideas that suggest alternate ways of visualizing. “The Art of Marine Science” is a new method that has been developed by MML scientists to address complex ecological issues by combining the talent of Ringling College of Art and Design students with research at Mote Marine Laboratory (MML) to produce outreach tools (Hall et al., 2012). We proposed to use this same method to develop outreach material on ocean acidification and potential effects on Florida coral reef ecosystems that can be used and displayed in aquariums, learning centers, classrooms, and as online resources. This project has increased awareness and literacy on ocean acidification and its effect of Florida coral reefs among students, tourists, and the general public with the production of unique outreach tools developed by talented art students working together with scientists. INTRODUCTION Ocean acidification, a consequence of anthropogenic CO2 production, is a complex ecological issue that is breaking ground in the marine scientific community. Currently, the ocean absorbs approximately one-third of the excess CO2 from the atmosphere, acting as a sink for atmospheric CO2, which leads to a reduction in pH and dramatic shifts in seawater carbonate chemistry (IPCC, 2007). Compared to preindustrial times, atmospheric CO2 concentrations are expected to triple within the next century (IPCC, 2013), resulting in a decreasing ocean surface pH to approximately 7.8 (instead of the typical pH of seawater at 8.2) (Caldiera and Wickett, 2003; Feely et al., 2004; Feely et al., 2009; Riebesell et al., 2000; Wolf-Gladrow et al., 1999). Ocean acidification will likely directly impact marine organisms that build shells or skeletons from calcium carbonate such as corals (Doney et al., 2009a; Fabry et al., 2008; Guinotte and Fabry et al., 2008; Hoegh-Guldberg et al., 2007; Iglesias-Rodriguez et al., 2008; Riebesell et al., 2000), and it has been speculated that the already present decline in the Florida Keys ecosystem health could be exacerbated by ocean acidification (Feely 2009; Kleypas and Yates, 2009). Therefore, reef resilience or reef behavior to ocean acidification in the Florida Keys is of great concern, and this concern needs to be communicated to the public.
Multi-Vector-Based Model Predictive Torque Control for a Six-Phase PMSM Motor With Fixed Switching Frequency

This paper proposes a multi-vector-based model predictive torque control with fixed switching frequency for a six-phase permanent-magnet synchronous machine to improve its steady-state performance. First, two active vectors are synthesized in each control period to suppress the stator current harmonics in x–y subspace. For the sake of easy implementation in the real-time system, the vectors are artfully synthesized in two different manners. Second, to achieve the fixed switching frequency, two null vectors are inserted along with the synthesized vector. The duty ratio of the null vectors is determined based on the principle of deadbeat torque control. In the meantime, the synthesized vector and its duty ratio are evaluated simultaneously by the cost function. In this way, the torque ripple can be reduced considerably. Thus, with the proposed method, both the current harmonics and the torque ripple are reduced effectively. Also, the proposed methodology can be readily implemented practically under the constant switching frequency. Finally, the experimentation is carried out to verify the validity of the proposed method.
Biogenesis of ZnO nanoparticles using Pandanus odorifer leaf extract: anticancer and antimicrobial activities

The continuously increasing incidence rates of cancer and infectious diseases are open threats to the sustainable survival of animals and humans. In the last two decades, the demands of nanomaterials as modern therapeutic agents have increased. In this study, biogenic zinc oxide nanoparticles (ZnO NPs) were developed from aqueous Pandanus odorifer leaf extract (POLE) and characterized using modern methods and tools, such as electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy and UV-vis spectroscopy, which indicated the formation of very pure, spherical NPs approximately 90 nm in size. The anticancer activity of the ZnO NPs was evaluated by MTT and neutral red uptake (NRU) assays in MCF-7, HepG2 and A-549 cells at different doses (1, 2, 5, 10, 25, 50, 100 μg ml−1). Moreover, the morphology of the treated cancer cells was examined by phase contrast microscopy. The results suggest that the synthesized ZnO NPs inhibited the growth of the cells when applied a concentration from 50–100 μg ml−1. Moreover, the biogenic ZnO NPs were analysed as an antimicrobial agent against pathogenic bacteria. The highest antibacterial activity was observed against Gram-positive Bacillus subtilis (26 nm) and Gram-negative Escherichia coli (24 mm) at 50 μg per well. Complete bacterial growth (100%) vanished 100% upon treatment with ZnO NPs at 85 μg ml−1. Overall, POLE mediated derived biogenic ZnO NPs could serve as a significant anticancer and antimicrobial agent and be used in the development of novel drugs and skin care products.
Adoption of Android smartphones and intention to pay for mobile internet: an empirical analysis of consumers in Pakistan

This study examined the influencing factors of Android smartphone's adoption and the intention to pay for mobile internet. The study was grounded in theory of reasoned action (TRA) to develop the framework of the study. Through an adapted 5-point Likert scale questionnaire, in total, 324 responses were analysed using PLS-SEM technique. The findings of the study revealed that design aesthetics, interface convenience and perceived infrastructure have a significant role in building phone users attitude towards using smartphone's, with the exception of perceived content. The attitude also appeared as a significant factor in influencing intention to adopt Android-powered smartphone's. Emotional value, performance/quality value, and social value had a significant impact on the development of intention to pay for mobile internet. However, the findings of the study failed to validate the impact of adoption of Android-powered smartphone's and price/value for money on the intention to pay for mobile internet services. The findings are valuable for the manufacturers of Android smartphone's in designing the mobile devices and for the service providers of mobile internet to design effective marketing strategies.