Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of Sonohysterography and Hysterosalpingography with Hysteroscopy in the Diagnosis of Intrauterine Lesions

Background/Objective: One of the causes of inevitable abortion is structural abnormalities of the uterine cavity and endometrium, which interfere with the implantation of the embryo. We performed this study to compare the efficacy of sonohysterography and hysterosalpingography with hysteroscopy in the diagnosis of these abnormalities. Patients and Methods: This cross-sectional study was conducted on 72 infertile women who were candidates for hysteroscopy, attended to the Infertility Clinics of Vali-e-Asr Reproductive Health Research Center, affiliated to Tehran University of Medical Sciences. In this study, hysterosalpingography and sonohysterography were performed prior to hysteroscopy, which was considered as the gold-standard test for the diagnosis of the structural abnormalities of the uterine cavity and endometrium. Results: Comparing to hysteroscopy, sonohysterography had a sensitivity of 30%, a specificity of 100%, a positive predictive value of 100% and a negative predictive value of 30%; hysterosalpingography had a sensitivity of 55%, a specificity of 68%, a positive predictive value of 41% and a negative predictive value of 60%. Conclusion: Due to the absence of the complications associated with hysteroscopy, being an uninvasive procedure, with high sensitivity, lower cost, and higher feasibility, sonohysterography seems to be a suitable choice for diagnosing intrauterine lesions.
Individual participant data meta‐analysis of intervention studies with time‐to‐event outcomes: A review of the methodology and an applied example

Many randomized trials evaluate an intervention effect on time‐to‐event outcomes. Individual participant data (IPD) from such trials can be obtained and combined in a so‐called IPD meta‐analysis (IPD‐MA), to summarize the overall intervention effect. We performed a narrative literature review to provide an overview of methods for conducting an IPD‐MA of randomized intervention studies with a time‐to‐event outcome. We focused on identifying good methodological practice for modeling frailty of trial participants across trials, modeling heterogeneity of intervention effects, choosing appropriate association measures, dealing with (trial differences in) censoring and follow‐up times, and addressing time‐varying intervention effects and effect modification (interactions). We discuss how to achieve this using parametric and semi‐parametric methods, and describe how to implement these in a one‐stage or two‐stage IPD‐MA framework. We recommend exploring heterogeneity of the effect(s) through interaction and non‐linear effects. Random effects should be applied to account for residual heterogeneity of the intervention effect. We provide further recommendations, many of which specific to IPD‐MA of time‐to‐event data from randomized trials examining an intervention effect.We illustrate several key methods in a real IPD‐MA, where IPD of 1225 participants from 5 randomized clinical trials were combined to compare the effects of Carbamazepine and Valproate on the incidence of epileptic seizures.
101 spots: Find the primary site

Abstract is not required for Clinical Imagesis not required for Clinical Images (This page in not part of the published article.) International Journal of Case Reports and Images, Vol. 6 No. 11, November 2015. ISSN – [0976-3198] Int J Case Rep Images 2015;6(11):727–729. www.ijcasereportsandimages. com Bera et al. 727 CASE REPORT OPEN ACCESS 101 spots: Find the primary site Geraldine Bera, Gabriel Malouf, Nathanaëlle Yeni, Charlotte Lepoutre-Lussey
WAVELET FAMILIES COMPARISON FOR R-PEAKS DETECTION IN ELECTROCARDIOGRAM SIGNAL

A detection of R-peaks in electrocardiogram signal (ECG) based on modified threshold in wavelet transform domain is presented. In this paper, the threshold determination is based on segmentation approach and with help of different wavelet families. However, the decision about the possible R-peaks is done by using the physiological heart parameters. Our method has been applied to MIT-BIH arrhythmia database to show its practical efficiency in terms of sensitivity, median, mean and standard deviation values. A comparative study is done between the results of our proposed algorithm based on modified threshold with different wavelets combinations, and the work based only on Daubechies wavelet with simple threshold. The survey showed that the combination of Daubechies wavelet mother gives with Symlet, Coiflet and Biorthogonal wavelets mother the best results.
The significance of biochemical markers in the diagnosis of acute coronary syndrome

Cardiac biomarkers are standard part of contemporary cardiology practice. They reflect basic pathophysiological processes that underlie acute coronary syndromes: damage and necrosis of myocardial cells, inflammation, neurohumoral activation and changes in left ventricular and renal function. Ideal goal is to find a marker that would have high sensitivity and specificity in early phases of acute coronary syndromes. Breakthroughs in technology resulted in an array of 'pointof- care' (POC) tests that are becoming increasingly important, due to rapid results of testing.
Efficient Outlier Detection Using Graph Based Semi Supervised Clustering with BAT Algorithm

-Outlier detection is a fundamental issue in data mining, specifically it has been used to detect and remove anomalous objects from data. It is an extremely important task in a wide variety of application domains. The existing research method named as Expectation Maximization Particle Swarm Optimization Weighted Clustering (EMPWC) outlier detection technique is used for detecting the outliers more efficiently. However it has issue with handling the unbalanced dataset and time complexity. To avoid the above mentioned issues, in this research, BAT optimization based semi supervised algorithm is proposed. It has three phases such as pre-processing, outlier estimation using BAT algorithm and clustering using semisupervised algorithm. The pre-processing is done by using min-max normalization approach which is sued to increase the outlier detection accuracy. The outlier detection is improved by using BAT optimization algorithm which is achieved by best objective function. The clustering is done by Graph based Semi Supervised (GSS) algorithm. The GSS based BAT (GAABAT) approach is used to improve the performance metrics such as execution time and false alarm rate compare than existing methods. The experiment results on large scale categorical datasets have shown that the IBAT with semi supervised based outlier detection ensures a better trade-off between Detection Rate (DR), False Alarm Rate (FAR) than the existing outlier detection schemes.
Optimizing the Quality of Colorectal Cancer Screening Worldwide.

Screening, followed by colonoscopic polypectomy (or surgery for malignant lesions), prevents incident colorectal cancer and mortality. However, there are variations in effective application of nearly every aspect of the screening process. Screening is a multistep process, and failure in any of single step could result in unnecessary morbidity and mortality. Awareness of variations in operator- and system-dependent performance has led to detailed, comprehensive recommendations in the United States and Europe on how colonoscopy screening should be performed and measured. Likewise, guidance has been provided on quality assurance for non-primary colonoscopy-based screening programs, including strategies to maximize adherence. Quality improvement is now a validated science, and there is clear evidence that higher quality prevents incident cancer and cancer death. Quality must be addressed at the levels of the system, provider, and individuals, to maximize the benefits of screening for any population. We review the important aspects of measuring and improving the quality of colorectal cancer screening.
A structural role for the PHP domain in E. coli DNA polymerase III A structural role for the PHP domain in E. coli DNA polymerase III Let us know how access to this document benefits you.

Background: All retroviruses synthesize essential proteins via alternatively spliced mRNAs. Retrovirus genera, though, exploit different mechanisms to coordinate the synthesis of proteins from alternatively spliced mRNAs. The best studied of these retroviral, post-transcriptional effectors are the trans -acting Rev protein of lentiviruses and the cis -acting constitutive transport element (CTE) of the betaretrovirus Mason-Pfizer monkey virus (MPMV). How members of the gammaretrovirus genus translate protein from unspliced RNA has not been elucidated. Results: The mechanism by which two gammaretroviruses, XMRV and MLV, synthesize the Gag polyprotein (Pr65 Gag ) from full-length, unspliced mRNA was investigated here. The yield of Pr65 Gag from a gag – only expression plasmid was found to be at least 30-fold less than that from an otherwise isogenic gag-pol expression plasmid. A frameshift mutation disrupting the pol open reading frame within the gag-pol expression plasmid did not decrease Pr65 Gag production and 398 silent nucleotide changes engineered into gag rendered Pr65 Gag synthesis pol -independent. These results are consistent with pol- encoded RNA acting in cis to promote Pr65 Gag translation. Two independently-acting pol fragments were identified by screening 17 pol deletion mutations. To determine the mechanism by which pol promoted Pr65 Gag synthesis, gag RNA in total and cytoplasmic fractions was quantitated by northern blot and by RT-PCR. The pol sequences caused, maximally, three-fold increase in total or cytoplasmic gag mRNA. Instead, pol sequences increased gag mRNA association with polyribosomes ~100-fold, a magnitude sufficient to explain the increase in Pr65 Gag translation efficiency. The MPMV CTE, an NXF1-binding element, substituted for pol in promoting Pr65 Gag synthesis. A pol RNA stem-loop resembling the CTE promoted Pr65
Metabolic fingerprints discriminating severity of acute ischemia using in vivo high‐field 1H magnetic resonance spectroscopy

Despite the improving imaging techniques, it remains challenging to produce magnetic resonance (MR) imaging fingerprints depicting severity of acute ischemia. The aim of this study was to evaluate the potential of the overall high‐field 1H MR Spectroscopy (1H‐MRS) neurochemical profile as a metabolic signature for acute ischemia severity in rodent brains. We modeled global ischemia with one‐stage 4‐vessel‐occlusion (4VO) in rats. Vascular structures were assessed immediately by magnetic resonance angiography. The neurochemical responses in the bilateral cortex were measured 1 h after stroke onset by 1H‐MRS. Then we used Partial‐Least‐Squares discriminant analysis on the overall neurochemical profiles to seek metabolic signatures for ischemic severity subgroups. This approach was further tested on neurochemical profiles of mouse striatum 1 h after permanent middle cerebral artery occlusion, where vascular blood flow was monitored by laser Doppler. Magnetic resonance angiography identified successful 4VO from controls and incomplete global ischemia (e.g., 3VO). 1H‐MR spectra of rat cortex after 4VO showed a specific metabolic pattern, distinct from that of respective controls and rats with 3VO. Partial‐Least‐Squares discriminant analysis on the overall neurochemical profiles revealed metabolic signatures of acute ischemia that may be extended to mice after permanent middle cerebral artery occlusion. Fingerprinting severity of acute ischemia using neurochemical information may improve MR diagnosis in stroke patients.
Enfermedad diverticular del colon y neumatosis porta. Reporte de un caso

* Cirujano General, International Research and Clinical Fellow, Surgical Critical Care and Trauma Surgery, Los Angeles County-University of Southern California Medical Center, Los Angeles, Ca, USA. ** Cirujano General, Hospital Militar Regional, Tuxtla Gutiérrez, Chiapas. *** Cirujano General, Hospital Ángeles de León, León, Guanajuato. **** Cirujano General, Residente de la Subespecialidad de Oncología Quirúrgica, Instituto Nacional de Cancerología, México, D.F.
Effect of Occupational Exposure to Radar Radiation on Cancer Risk: A Systematic Review and Meta-Analysis

Objective: Microwave radiation is one of the most growing environmental workplace factors that exposes too many workers in the various workplaces. Regard to concerns about cancer incidence in these workers and lack of systematic or meta-analytic studies about this object, so, we conducted a meta-analysis to acquire an understanding of the association between cancer risk and occupational exposure to radar radiation. Methods: A systematic search was carried out on case-control, cohort and clinical control trial studies that published in the Cochrane Library, PubMed, ISI Web of Science, Scopus and Google scholar databases that accomplished from March 2017 to March 2018 and updated on 30 September, 2018 in English and Persian articles without time limit in publication date. Keywords were selected based on PICO principle and collected from MeSH database. After removal of duplicated studied, taking into inclusion and exclusion criteria, the process of screening was carried out and data were extracted after preparation of the full text of included articles. Article collection was completed by manually searching for a reference list of eligible studies. For quality assessment of included studies, Newcastle-Ottawa scale was used. Results: a total of 533 studies was found in the first step of literature search, only 6 were included with 53,008 sample size according to inclusion and exclusion criteria. Estimated pooled random effects size analysis showed no significant increasing effect of occupational exposure to radar radiation on mortality rate (MR=0.81, 95%CI: 0.78, 0.83) and relative risk (RR=0.87, 95%CI: 0.75, 0.99, P <0.0001) of cancer with a significant heterogeneity between the selected studies. Conclusions: In conclusion, the results of this meta-analysis study have shown no significant increase in overall mortality ratio and cancer risk ratio from occupational exposure to the radar frequency of workers. But, these results are not conclusive. As regards to some limitation such as fewer numbers of included studies, lack of data about exposure characterizations and demographic characterizations in this meta-analysis, this result is not certain and conclusive. It is recommended to conduct future studies.
Protein lysine methylation contributes to modulating the response of sensitive and tolerant Arabidopsis species to cadmium stress.

The mechanisms underlying the response and adaptation of plants to excess of trace elements are not fully described. Here, we analyzed the importance of protein lysine methylation for plants to cope with cadmium. We analyzed the effect of cadmium on lysine-methylated proteins and protein lysine methyltransferases (KMTs) in two cadmium-sensitive species, Arabidopsis thaliana and A. lyrata, and in three populations of A. halleri with contrasting cadmium accumulation and tolerance traits. We showed that some proteins are differentially methylated at lysine residues in response to Cd and that a few genes coding KMTs are regulated by cadmium. Also, we showed that nine out of 23 A. thaliana mutants disrupted in KMT genes have a tolerance to cadmium that is significantly different from that of wild-type seedlings. We further characterized two of these mutants, one was knocked-out in the calmodulin lysine methyltransferase gene and displayed increased tolerance to cadmium, the other was interrupted in a KMT gene of unknown function and showed a decreased capacity to cope with cadmium. Together, our results showed that lysine methylation of non-histone proteins is impacted by cadmium and that several methylation events are important for modulating the response of Arabidopsis plants to cadmium stress.
Different Role of Caveolin-1 Gene in the Progression of Gynecological Tumors

Caveolin-1 (Cav-1), an integral membrane protein, is a principal component of caveolae and has been reported to play a promoting or inhibiting role in cancer progression. Gynecologic tumor is a group of tumors that affect the tissue and organs of the female reproductive system, especially cervical cancer. Cervical cancer, as one of the most common cancers, severely affects female health in developing countries in particular because of its high morbidity and mortality. This review summarizes some mechanisms of Cav-1 in the development and progression of gynecological tumors. The role of Cav-1 in tumorigenesis, including dysregulation of cell cycle, apoptosis and autophagy, adhesion, invasion, and metastasis, such as the formation of invadopodia and matrix metalloproteinase degradation are presented in detail. In addition, Cav-1 modulates autophagy and the formation of invadopodia and target regulated by miRNAs to affect tumor progress. Taken together, we find that, no matter Cav-1 expression in the tumor or stromal cells , Cav-1 has paradoxical role in different types of gynecological tumors in vivo or in vitro and even in the same tumor from the same organ.
Rehabilitation and prevention of complications after total hip arthroplasty

A comparative analysis of the structure and frequency of complications after total hip replacement (THR) and basic methods of prevention based on experience treating 303 patients with diseases and injuries of the hip joint. It is proved that a comprehensive system of rehabilitation of patients, which includes preoperative preparation, prevention of complications, operation planning and original methods of treatment, diagnostics and physiotherapy, for each stage of treatment, up to the final physiological and social rehabilitation, provides a significant reduction in the number of complications, achieving optimal outcomes of treatment and functional outcomes.
Combined immuno-chemotherapy (R-FCM) results in superior remission rates and overall survival in recurrent follicular and mantle cell lymphoma: Follow-up of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG)

6528 Background: Rituximab monotherapy has shown a high activity in relapsed follicular lymphomas. Recently, phase III studies indicated that its addition to chemotherapy may further improve the progression-free survival substantially. Methods: In 1998 the GLSG embarked on a multicenter national trial in patients with relapsed or refractory follicular and mantle cell lymphoma. As most patients had received CHOP for first line treatment, a fludarabine-containing regimen (FCM) was chosen for salvage therapy followed by an optional Rituximab maintenance. A total of 4 courses were given. After the statistical analysis confirmed the significantly improved response rate of the combined study arm (R-FCM), 111 subsequent patients were designated to immuno-chemotherapy. Results: 122 of 244 currently evaluable patients (50%) had follicular, 95 patients (39%) mantle cell and 24 patients (10%) other indolent lymphomas. In 67 randomized patients with follicular lymphoma, complete (39% vs. 23%, p=0.013) as well as over.
Treatment for Newly Diagnosed Hypertension: Patterns of Prescribing and Antihypertensive Effectiveness in the UK

Improved practice in the management of hypertension depends on an understanding of existing patterns of treatment. To describe the management of newly diagnosed hypertension in British general practice and the effectiveness of current prescribing patterns we conducted a retrospective observational study using data from a computerized general practitioner record database (DIN-LINK). 21 024 patients were first treated for newly diagnosed hypertension between January 1993 and December 1997, and were followed for 4 years. Diuretics or beta-blockers were the most widely prescribed first-line treatments, used in 54% of patients. The mean continuation rate for first-line therapy was 69% at 12 months: the continuation rate was highest for angiotensin converting enzyme inhibitors/angiotensin II receptor antagonists. After 12 months of treatment the mean blood pressure reduction was 19/10 mmHg. Blood pressure targets were met in only 14% of patients. After 48 months of treatment 34% of patients had not improved in band of blood pressure severity. Many patients with severe hypertension at 12 months were still being prescribed only one drug. The lack of aggression in antihypertensive treatment, indicated by the low number of agents prescribed and the failure to achieve targets, is disappointing. Prescribing patterns for first-line therapy corresponded to guidelines. Continuation rates on first-line therapy were higher than often reported. The choice of drug for additions to or switches from first-line therapy had no clear pattern. Routinely collected computerized data could be used to support clinical governance activities in primary care.
Health Capacity to Work at Older Ages: Evidence from Japan

This paper explores the extent to which older Japanese can potentially expand the labor supply, based on two analytic approaches: the Milligan-Wise and Cutler et al. methods. First, we examine how much older individuals could work if they worked as much as those with the same mortality rate in the past (the Milligan-Wise method). Second, we estimate how much older individuals could work if they worked as much as younger ones in similar health (the Cutler et al. method). Results from both of these methods underscore a large work capacity in old age in Japan. We further investigate differences in health capacity across education groups and find that highly educated individuals tend to have more capacity to work after they are 65 years of age.
Examining fallacies in diagnostic reasoning

The paper by Gurova takes issue with the claim of Meehl that ‘understanding makes it normal’ is a fallacy in diagnostic reasoning [1,2]. Her paper prompts the more general question of appropriate methods for testing whether a specific way of reasoning in making a clinical diagnosis is fallacious. So prompted, I will compare the methods that the Gurova paper deploys with some of requirements for testing whether a particular way of reasoning is fallacious. It should become clear in this comparison that the dictum ‘understanding it makes it normal’ per se is insufficient to proclaim whether reasoning by it is fallacious.
Political Violence and Mental Health

Questions about mental health and psychological well-being are incompatible with the atmosphere of war, political repression, and national struggle. The aim of war is not only to defeat the the opponent militarily but also to break down the morale of the civilian population on the enemy's side. Mental health problems are thus easily considered an indication of weakness, cowardliness, and withdrawal from the struggle. The main task of the civilian population is to develop special social and psychological strategies that will help the people not only to face the atrocities but also to struggle for their abolition. In a society engaged in political conflict, mental health becomes a weapon. Both the relative paucity of psychological research on civilian mental health and the theoretical and ethical problems of such research are connected to this controversial social-political situation. Women and children are not considered as important as soldiers for the war effort, and societies at war direct a substantial proportion of their professional resources toward catering to the well-being and efficiency of the fighting soldiers [1,2]. According to Psychological Abstracts, 1983-1987,