Miracle-dz/UniFAR-FTUs huggingface dataset:
Differential gene expression of TGF-beta isoforms and TGF-beta receptors during the first trimester of pregnancy at the human maternal-fetal interface.

PROBLEM The transforming growth factor (TGF)-beta s are multifunctional cytokines, and they play a role in the controlled growth of trophoblasts. Moreover they are thought to be important in maternal-fetal interaction during early gestation. METHOD OF STUDY Human decidual and villous tissues in the first trimester were Northern blotted and amplified by reverse transcription-polymerase chain reaction to measure the expression of TGF-beta 1, -beta 2, and -beta 3 and their receptors, types I and II, at the first trimester of pregnancy. In addition, their cell-specific expression at the maternal-fetal interface was determined by in situ hybridization. RESULTS Each isoform of TGF-beta was expressed in both decidual and villous tissues. Because most TGF-beta 1 gene expression was found in villous tissues, TGF-beta 2 mRNA was expressed preferentially in the decidual tissues. TGF-beta 3 transcripts were expressed in the nonpregnant endometrium. CONCLUSIONS The results suggest that each isoform of TGF-beta plays some specific role in decidualization and placentation. Furthermore, it is predicted that they regulate the maternal-fetal interaction at early gestation.
Semipolar (11–22)-based InGaN/GaN quantum wells for visible light emitters

Visible light emitting diodes (LEDs) using semipolar (11–22)-oriented InGaN/GaN quantum wells (QWs) were demonstrated. Three dimensional microfacet structures realized white/pastel emissions without phosphors, while planar structures led to LEDs with much less polarization-induced internal electric fields compared to the conventional LEDs on the (0001) plane, both of which cannot be realized without the (11–22) planes.
4713 Robust Mechanism Design and Social Preferences

We study a classic mechanism design problem: How to organize trade between two privately informed parties. We characterize an optimal mechanism under selfish preferences and present experimental evidence that, under such a mechanism, a non-negligible fraction of individuals deviates from the intended behavior. We show that this can be explained by models of social preferences and introduce the notion of a social-preference-robust mechanism. We characterize an optimal mechanism in this class and present experimental evidence that it successfully controls behavior. We finally show that this mechanism is more profitable only if deviations from selfish behavior are sufficiently frequent. JEL-Code: C920, D030, D820.
Internet Gaming Disorder: A Case Report.

Internet use and video game playing are experiencing rapid growth among both youth and adult populations. Internet gaming is one of the most popular sources of entertainment for people in all ages, but excess playing this game causes negative consequences including video game addiction. IGD is not currently a recognized diagnosis in the Dignostic and Statistical Manual for Mental Disorders-5 (DSM-5). However, IGD has been noted to warrant further research for possible future inclusion in the DSM. The excessive usage in the majority of cases was purely symptomatic and was highlighted how the subject used the internet or computer to counteract other problems. IGD strongly resembles substance and gambling addictions. Such characteristics include tolerance, withdrawal, and social and occupational neglect resulting from increased time invested in video game use and acquisition. We report a case of 20-year old student who used to addict internet video gaming to counteract his stress and social problem.
The Fall Armyworm Triose Phosphate Isomerase (Tpi) Gene as a Marker of Strain Identity and Interstrain Mating

ABSTRACT Fall armyworm, Spodoptera frugiperda (J.E. Smith), is a significant agricultural pest in the United States, affecting most notably sweet corn, Zea mays L. , and turfgrass. Two strains exist that differ physiologically and behaviorally but are morphologically indistinguishable. Polymorphisms within the fall armyworm Triose phosphate isomerase gene (Tpi; EC 5.3.1.1) were characterized and used to develop a polymerase chain reaction-based method for discriminating fall armyworm strains. The Tpi markers were used in multilocus analysis to estimate interstrain hybrid frequency and their distribution in populations from the United States and Brazil. The results were compared with previous studies using different marker combinations to test hypotheses about interstrain mating behavior and to explain earlier observations of unusual strain distribution patterns. The importance of understanding the frequency and consequences of interstrain hybridization to deciphering the mechanism of strain divergence and the distribution of fall armyworm subpopulations in different habitats are discussed.
The Diagnosis of Alzheimer's Disease Based on Voxel-Based Morphometry and Support Vector Machine

The purpose of this study was to explore the automatic method of detecting the gray matter loss of Alzheimerpsilas disease (AD) patients with magnetic resonance imaging (MRI). In this paper, voxel-based morphometry (VBM) and support vector machine (SVM )were combined and introduced to diagnose Alzheimer's disease(AD) for clinical applications. Firstly, with the VBM method, 20 features were obtained from the accurate structure imaging of possible AD and the controls, and then the principal component analysis (PCA) was used for feature dimensionality reduction to improve the efficiency. Then, a SVM classifier with linear kernel function was used to distinguish AD from healthy controls. Finally, the performance of SVM was evaluated. The accuracy of classifier is proportional to the number of training samples. With 18 training samples, the predictive capability of SVM could reach 100%. And the results will be slightly better under the process of PCA with fewer features. In conclusion, the results of this study confirmed that the method of combining VBM with SVM could be used as an automatic tool for the early diagnosis of AD.
Effect of low amount of nanosilica on dielectric properties of polypropylene

This paper presents the results of the dielectric properties measurements conducted on Silica-Polypropylene (PP) nanocomposites. According to prior investigations by the authors silica nanoparticles have improved the performance of the dielectric material considering capacitor applications. Especially breakdown strengths with ac and dc voltages and resistance against surface degradation have increased. The relative permittivity and dielectric losses have also been comparable to reference PP. In this paper the results of the dielectric measurements conducted on composites with 1–2 wt-% silica are compared with reference PP. Silica dispersion in PP was confirmed with transmission electron microscopy (TEM). Weibull analysis was applied to the breakdown strength measurement results with dc voltage. Capacitance and loss factor measurements were conducted as a function of temperature to study thermal behavior. The measurements were conducted at the high voltage laboratories of Tampere University of Technology and Chalmers University of Technology. Statistical analysis was applied to the results to determine the significance of the differences between the materials.
First insights into regiospecific transnitrosation reactions between tryptophan derivatives: melatonin as an effective target

Abstract: Melatonin, a derivative of the essential amino acid tryptophan, has been portrayed as a hormone, a tissue factor, an autocoid, a paracoid, and a vitamin with antioxidative capabilities. In the present study a novel reaction which cannot be attributed to any of these suggested features, i.e. the transfer of the nitroso‐function from N‐nitrosotryptophan derivatives to melatonin, is unequivocally demonstrated. In the lipophilic buffer dimethylsulfoxide reaction of N‐acetyl‐N‐nitrosotryptophan (NANT) with melatonin was very slow (k = 1.5 × 10−6/m/s), but reversible as shown by 15N‐NMR spectrometry. These measurements demonstrated also that the thermodynamical equilibrium lies on the side of N‐nitrosomelatonin (NOMela). Quantum‐chemical calculations performed with the third‐generation density functional B97‐2 additionally predicted that this is also the case in an aqueous environment. In fact, reaction of melatonin with either NANT or N‐nitrosotryptophan located at the endothelin‐1 fragment 16–21 yielded NOMela with a rate constant of 1.7 ± 0.5/m/s as shown by capillary zone electrophoresis. Interestingly, the known reactive nitrogen oxide species scavenger, piperazine, did not inhibit the NANT‐dependent nitrosation of melatonin, thus very strongly indicating a direct transnitrosation reaction. All of these capabilities are known from the reaction of S‐nitrosothiols with thiolate anions and are believed to be highly important in the transport and targeting of nitric oxide.
Tx/Rx isolation enhancement based on a novel Balanced Duplexer architecture

Duplexers are essential circuit elements in virtually all Frequency Division Duplex (FDD) communication systems. Duplexers provide filtering functions for transmission and reception bands; moreover they provide isolation. In this work we present a novel duplexer architecture that provides increased isolation without increasing the constituting filters order. Among the advantages of this novel technique is the reduction of filter complexity, a 3-dB reduction in filter power handling capacity and improved isolation bandwidth. Two duplexers have been designed, fabricated and characterized. A UMTS duplexer was designed fabricated on RO5870 substrate. Another duplexer in 5.1GHz–5.8GHz band was designed and fabricated on Alumina substrate. The results obtained by measurements validated the utility of the architecture in enhancing the Transmitter-Receiver isolation by 15dB–20dB over nearly the full band of the filters in both designs.
Lateral versus vertical gate-all-around FETs for beyond 7nm technologies

Nominal LG VFET-based RO may operate up to ~60% faster than LFET-based RO at the same energy per switch for both 7nm and 5nm technology nodes depending on the layout and BEOL-load. With VFETs, relaxing the LG is possible and it results in an extra 27% in IEFF in comparison to the nominal LG case. In addition, VFETs enable different layouts, which can be used to optimize performance under certain BEOL-load. Introduction of VFETs is more favorable at the 5nm node than at the 7nm node. As such, VFETs show a performance competitive path for continued scaling beyond 7nm technologies.
Large Scale Molecular Dynamics Simulation of Aqueous NaCl Solutions

The understanding of aqueous solution properties is recognized as being important in many areas of physical chemistry and molecular biophysics. Computer simulation has become an important tool in understanding the structure and dynamics of aqueous electrolyte solutions at the atomic or molecular level. Many works of molecular dynamics (MD) simulations have been carried out to investigate hydration structure and dynamic properties of aqueous solutions [1–4]. We carried out large scale molecular dynamics simulations to investigate the concentration dependence of solute ion’s behaviors in aqueous NaCl solution. In the dilute limit of solute, there must be no Na-Cl pair formation. However, it is very difficult to detect the existence of Na-Cl pairs experimentally. This prompts us to study the microscopical structure of aqueous NaCl by using MD simulation at three concentration conditions; 0.05 mol% (0.028M), 0.10 mol% (0.055M) and 0.50 mol% (0.276M). In this work, we carried out two series of MD simulations. In the first series, Amber potential set [5] was adopted for NaCl-water and NaCl-NaCl interactions. This potential is constructed by a Lennard-Jones term and a Coulomb term. Parameters of this potential are taken from Amber force field [6,7]. These parameters were determined based on the energy of hydration of Na-water and Cl -water. In the second series, Tosi-Fumi potential [8] was adopted as inter-ionic ones. This potential was made for solid alkali halide systems, such as crystalline NaCl and KCl. And, it is possible to reproduce their liquid structures, diffusion constants, electrical conductivities and viscosities very well [9]. Amber potential set was also employed for solution-water interactions in the second series. MD simulation of low concentration condition requires a large scale system. We have developed a special-purpose computer, MDM (Molecular Dynamics Machine) [10–13], to carry out a large scale MD simulation. The MDM can perform very high-speed MD simulation of a Coulomb system using the Ewald method. The MDM consists of a MDGRAPE-2 part, a WINE-2 part and a host computer. The calculation speed of the MDM is 10100 times faster than that of a general purpose computer. We used the MDM in the present work.
Efficacy of donor screening for HTLV‐I and the natural history of transfusion‐transmitted infection

BACKGROUND: It has been 10 years since the implementation in Japan of donor blood screening for human T‐cell lymphotropic virus type I (HTLV‐I). This report reviews the effectiveness of screening in preventing transmission of HTLV‐I through blood transfusion and the current status of patients with confirmed seroconversion due to transfusions given before the implementation of screening.
Observation of quantum collapse and revival in a one-atom maser.

The dynamics of the interaction of a single Rydberg atom with a single mode of an electromagnetic field in a superconducting cavity was investigated. Velocity-selected atoms were used and the evolution of the atomic inversion as atom and field exchange energy was observed. The quantum collapse and revival predicted by the Jaynes-Cummings model were demonstrated experimentally for the first time. The evaluation of the dynamic behavior of the atoms allows us to determine the statistics of the few photons in the cavity.
Cerebral perfusion pressure versus intracranial pressure-driven therapy on outcomes.

To the Editor: I read with great interest the article on cerebral perfusion pressure (CPP) versus intracranial pressure (ICP)– driven therapy on outcomes in pediatric patients (1). The authors should be commended for this work, which is an important study regarding the monitoring of brain perfusion (CPP) versus simply monitoring ICP. CPP, which measures mean arterial pressure (MAP) minus ICP, is a more meaningful number than ICP in isolation. CPP is useful because it correlates linearly with cerebral blood flow (CBF) when autoregulation is absent. When autoregulation is present, CBF is held constant over a range of CPP—that is, the so-called autoregulation plateau (2). The authors’ findings are important in making sense of prior traumatic brain injury literature and data in which ICP treatment alone may or may not have had correlation with outcomes (3). Further, in critically ill patients, it is more likely that a “bundle” of interventions such as those to reduce ventilator-associated pneumonia (VAP) are more effective than a single intervention. It is curious that transient hyperventilation was employed at a higher rate in the authors’ ICP group, but perhaps this is because the list of treatment options for ICP is shorter than for CPP (e.g., vasopressors, hyperventilation, and osmotherapy could be used). Also, in the Methods section, it was not mentioned whether the MAP arterial transducer was set at the level of the tragus (CPP = MAP – ICP) so that both ICP and MAP are “zeroed” with reference to the intracranial compartment (2). Movement of the arterial transducer upward above the right atrium to the tragus will reduce the systolic blood pressure primarily and potentially the MAP, especially in patients who have the head of bed elevated 30° for various reasons (e.g., to reduce VAP). Dr. Freeman received book royalties from Oxford, Cambridge.
A dynamic biped walking robot based on the momentum mechanism with flexible beams

A dynamic biped walking robot based on the momentum mechanism with flexible beams is proposed. This robot has two legs which are a pair of flexible beams instead of a pair of rigid crura and femurs. The flexible beams are expected to bring a light weight robot, and also act as joints at knees which have been operated by electric or hydraulic motors. A computer model of the present robot has been developed, and the dynamic behavior is analyzed and displayed by animation, here. Furthermore, a prototype model which walks by dynamic human gait was designed, setup and inspected. As the result we found the following features. (1) The weight of the proposed robot can be reduced to half as compared with conventional rigid body robots. (2) Rapid and stable walking can be attained by the swift movement of the flexible legs. (3) Energy consumption for dynamic walking is reduced to 70% as compared with rigid body robots. <<ETX>>
Talenti creativi multipli: quali determinanti a livello locale?

La creatività è attualmente al centro di un vivace dibattito scientifico che coinvolge studiosi provenienti da discipline diverse (1). L’interesse per l’argomento è fondamentalmente dovuto al potenziale impatto positivo che si ritiene la creatività possa avere sullo sviluppo economico (e.g. Florida 2002, EC 2010, UNCTAD 2008 e 2010); di conseguenza, comprendere le determinanti degli specifici modelli locali di specializzazione creativa risulta rilevante in termini di policy. Tuttavia, benché la letteratura esistente abbia identificato alcuni driver di creatività, l’evidenza empirica relativa al loro impatto specifico su particolari talenti creativi e sul grado di complessità creativa di un territorio è ancora estremamente scarsa.
CSR, SUSTAINABILITY, GOVERNANCE, AND ACCOUNTABILITY: THE CURRENT POSITION IN THE BODY OF KNOWLEDGE AND THEIR RESEARCH DIRECTIONS

Corporate social responsibility (CSR) term as we have known right now has been introduced firstly in the 1950s with the publication of a book entitled Social Responsibilities of the Businessman by Howard R. Bowen (Beal, 2014; KPMG. 2011). Since then so many definitions of the term have been developed by academicians, practitioners, and organizations (like GRI) with their own perspectives. Therefore, it seems that corporate social responsibility is a field of study, rather than a specific term with single meaning. As a field of study it can be closely related to other terms: sustainability, governance, and accountability. Crowther and Aras (2008), for example, provide the principle of CSR as having three elements: sustainability, accountability, and transparency. In addition, Gill (2008) tried to make CSR and governance as the closely related two terms, in that corporate governance is a reflection of corporate social responsibility and CSR is one form of corporate governance. Other terms often considered as synonymous of CSR are corporate sustainable performance, corporate citizen and corporate social performance (Beal 2014; Fauzi, Svensen, and Rahman, 2010). Even the terns such as social and environmental accounting (SEA) and green accounting are closely related to the CSR (Brown and Fraser, 2006); Cho and Patten, 2013).
Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition

Neuroblastoma (NB) is the most common extracranial solid tumor in childhood and arises from cells of the developing sympathoadrenergic lineage. Activating mutations in the gene encoding the ALK tyrosine kinase receptor predispose for NB. Here, we focus on the normal function of Alk signaling in the control of sympathetic neuron proliferation, as well as on the effects of mutant ALK. Forced expression of wild-type ALK and NB-related constitutively active ALK mutants in cultures of proliferating immature sympathetic neurons results in a strong proliferation increase, whereas Alk knockdown and pharmacological inhibition of Alk activity decrease proliferation. Alk activation upregulates NMyc and trkB and maintains Alk expression by an autoregulatory mechanism involving Hand2. The Alk-ligand Midkine (Mk) is expressed in immature sympathetic neurons and in vivo inhibition of Alk signaling by virus-mediated shRNA knockdown of Alk and Mk leads to strongly reduced sympathetic neuron proliferation. Taken together, these results demonstrate that the extent and timing of sympathetic neurogenesis is controlled by Mk/Alk signaling. The predisposition for NB caused by activating ALK mutations may thus be explained by aberrations of normal neurogenesis, i.e. elevated and sustained Alk signaling and increased NMyc expression.
Online Voting System Using Three FactorAuthentication

The voting percentage of India is very less & is considerably declining day by day. The illiterate people can be fooled & their votes can be casted to different candidates other than the one whom they wished to give away their votes. Also incidents like the booth capturing are increasing day by day & some undeserving candidates are getting elected & ruling our Nation, thus leading to the loss of nations property & other thing. Thus we the students have tried to make a sincere effort to put a stop to all this malicious activities & safeguard the right of voting of each & every individual of India. The software will provide a user friendly GUI using which the voters can caste their votes to different parties & the corresponding candidates. Different levels of security would be provided in the software which would help in authentication of an individual.We are providing Biometric for identifying an individual, Online Voting Application by which a user can be able to vote using Internet, Finger Recognition Hardware Interface, Steganography. Thus we plan to make the voting process a secure & effective one.
Statins alter intracellular calcium homeostasis in malignant hyperthermia susceptible individuals.

AIMS Statines, HMG-CoA reductase inhibitors, are widely used to treat hypercholesterinemia. These substances are well tolerated, but myotoxic effects have been reported. The exact mechanisms of the induced myotoxicity are unknown but an involvement of intracellular calcium handling is suspected. Individuals susceptible to malignant hyperthermia (MH) have an impaired calcium homeostasis. An in vitro test measuring contracture responses of isolated muscle bundles is used to investigate cellular processes of MH. Aim of this study was to investigate if statins modify the contracture response of isolated muscle bundles from MH susceptible (MHS) and nonsusceptible (MHN) pigs. METHODOLOGY With approval of the local ethics committee muscle biopsies of 18 MH susceptible and 12 nonsusceptible pigs were performed. Muscle bundles were mounted on an isometric force transducer, preloaded, and electrically stimulated. After establishment of a stable baseline, muscle bundles were exposed to simvastatin, atorvastatin, gemfibrocil, and the pure solvent. Baseline tension was measured and analyzed for changes with P < 0.05 considered to be significant. RESULTS There were no differences in weight, length, and predrug baseline tension between the groups. Both simvastatin and atorvastatin induced significant contractures in muscle bundles from MHS pigs. Gemfibrocil and the solvent methanol showed no effect. In MHN muscle bundles, none of the tested substances induced a contracture. Statines induce contractures only in MHS muscle bundles. CONCLUSION We therefore conclude that the underlying mechanism may be a pathologic influence on intracellular calcium handling that is absent in MHN. A preexisting impairment of the calcium homeostasis seems to be necessary for this behavior because muscle bundles of MHN pigs showed no pathologic reaction. A higher muscle cell vulnerability toward statins is assumed in MHS patients. Statins ought to be used with caution in these individuals. Analogous a diagnostic workup for MH should be considered for patients with statin-induced rhabdomyolyis.