Miracle-dz/UniFAR-FTUs huggingface dataset:
An Artificial Neural Network Based Early Prediction of Failure-Prone Students in Blended Learning Course

One of the objectives of the performance measurement of grade-based higher education is to reduce the failure rate of students. To identify and reduce the number of failing students, the learning activities and behaviors of students in the classroom must be continuously monitored; however, monitoring a large number of students is an extremely difficult task. A penetration of web-based learning systems in academic institutions revealed the possibility of evaluating student activities via these systems. In this paper, we propose an early prediction scheme to identify students at risk of failing in a blended learning course. We employ a neural network on the set of prediction variables extracted from the online learning activities of students in a learning management system. The experiments were based on data from 1110 student who attended a compulsory, sophomore-level course. The results indicate that a neural-network-based approach can achieve early identification of students that are likely to fail; 25% of the failing students were correctly identified after the first quiz submission. After the mid-term examination, 65% of the failing students were correctly predicted.
A Case Report of Gastrointestinal Hemorrhage and Perforation During Apatinib Treatment of Gastric Cancer

AbstractApatinib is a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2, which shows good efficacy and safety in clinical trials for chemotherapy-refractory gastric cancer patients. Till now, there is no case report after apatinib came in the market.We presented a 55-year-old Chinese woman with advanced gastric cancer, who received apatinib after failure of second-line chemotherapy. On the 19th day of apatinib administration, she suffered from gastrointestinal hemorrhage. Then, her condition rapidly deteriorated to gastrointestinal perforation. Although the patient received timely medical and surgical treatment, she finally died of septic shock.Although apatinib shows exciting efficacy and good tolerance in phase II and III clinical trials, this novel targeted drug should be prescribed carefully and close clinical monitoring is needed when using it.
SEROW IMU , Encoder , F / T RGB-D Image KFusion Visual Odometry KFusion Mapping Dense Map VO Pose Dense RGB

Visual Simultaneous Localization and Mapping (visual SLAM) constitutes a challenging task when applied to humanoid robots. While walking, the robot’s feet strike the ground and generate sudden accelerations due to rapid and sequential contact switching. These in turn give rise to visual motion blurriness that greatly compromises the performance of the system. In this work we present a dense visual SLAM approach that integrates information from IMU, robot kinematics and contact measurements, to overcome these issues.
A revisit of cytological features in phyllodes tumors

In surgery, as in other fields, approach has become more selective and conservative and a triple assessment of breast masses has facilitated this approach. Phyllodes tumors (PTs) were often recognized by their large size at presentation and subjected to wide excision or mastectomy. With the trend toward a diagnosis of these tumors at smaller size, the need arises for a well-defined evidence-based diagnostic algorithm to differentiate from fibroadenoma (FA) and to undergo wide excision at the first surgery and avoid a second surgery or recurrence. Many reports have described cytological features of PTs, problems in rendering a cytological diagnosis in few or many cases, emphasized on differentiating features between spindle cell lesions, and shared their experience in the inability to reproduce the appreciated or listed features in rendering or favoring a cytological diagnosis. [1] In this scenario, we attempted to retrace our journey and appreciate the shortcomings in this uncommon tumor with a lack of experience by many pathologists.
The Effects of Agro-Waste Reinforcing Fillers as Single and Hybrid on Mechanical and Thermal Properties of Polypropylene

Tarimsal hasatlardan ve budamadan sonra, Dunya'da milyarlarca ton tarimsal atik meydana gelir. Yalnizca az miktarda tarimsal atik gubre ve yakit olarak kullanilmaktadir ve geri kalani degerlendirilmemektedir. Kalan atik, sahada yakildiginda hava kirliligine neden olabilir. Bu nedenle, bu buyuk miktarda atik, polimerik kompozit urunler uretmek icin bir takviye veya dolgu malzemesi olarak kullanilabilir. Son on yilda, dogal elyaf/polimer kompozitlerin gelisimi cevre dostu karakteristikleri, dusuk maliyet, dusuk yogunluk vb. nedeniyle zemin kaplamasi, dis cephe kaplamasi ve otomotiv ic parcalari gibi bircok uygulamada populerlik kazanmistir. Bu calismada, polipropilen (PP) esasli kompozitlerde dogal takviyelendirici dolgu malzemeleri olarak pirinc kabugu (RH) ve asma cubugu’nun etkin kullanimi degerlendirilmistir. Bu calismada, kompozitlerin mekanik (cekme ve egilme dayanimlari ve Young’s ve egilme modulleri) ve termal (bozunma, erime ve kristallesme sicakliklari vb.) ozelliklerini incelemek icin farkli agirlik oranlarda RH (% 10,% 20 ve% 30) iceren RH-PP kompozitler ve hibrit RH-VS-PP matris kompozitler uretilmistir. RH-PP ve RH-VS-PP kompozitler, saf PP'ye kiyasla cok daha iyi mekanik ve termal ozellikler sergilemistir. RH-PP ve RH-VS-PP kompozitleri, maksimum bozulma sicakliginin daha yuksek bir bozunma sicakligina yer degistirmesiyle termal stabilitesinde bir artis gostermistir. RH-PP kompozitlere kiyasla, RH’in VS’ye orani 3: 7 oldugunda, RH-VS-PP kompozitleri daha iyi egilme ozellikleri sunmustur.
Chapter 1 How Long Can I Stay?

Abstract Aging in place has long been a focus for proponents of assisted living housing. However, the reality of life for seniors in assisted living is often tenuous, and this homelike setting repeatedly ends up being a temporary stop for older adults. Residents frequently ask, “How long can I stay? ”, only to find that there is no easy answer. Increasing frailty and declining health can mean that an elderly resident may be asked to leave assisted living, reducing aging in place in this housing/health care option to what I have termed “prolonged residence. ” Based on eighteen months of anthropological fieldwork at two assisted living sites in Chicago, Illinois, this article presents the individual struggles providers and residents face in interpreting aging in place. Although grappling with disparate aspects of the same issue, residents and providers both share conflicted feelings about how long one should remain in assisted living and what aging in place actually means.
INFLATION TARGETING IN A SMALL OPEN ECONOMY

The New Open Economy Macroeconomics (NOEM) literature has found that domestic price inflation should be a key target for the central banks. Still, these institutions typically pay attention to a broader set of macroeconomic variables, including wages and imported prices. In this paper I combine the sticky wage environment introduced by Erceg, Henderson, and Levin (2000) with the small open economy setup popularized in Galı́ and Monacelli (2005) to rationalize the observed behavior of the central banks. I derive a second-order approximation to household’s welfare losses and evaluate a number of different monetary rules. A simple Taylor rule containing a weighted composite of domestic prices and wages, with the weights being determined by deep parameters, can approximate the optimal policy reasonably well.
Hepatotoxicity: Its Mechanisms, Experimental Evaluation and Protective Strategies

The liver is a crucial organ for maintenance of gastrointestinal homeostasis and body function in general. In addition to its role in the digestive process, it also serves as a source of nutrients and detoxifier of unwanted substances. Hence, its optimal functioning is crucial for health and disease. An imbalance between aggressive and protective forces results in damage to the liver and complex mechanism are involved in such hepatotoxicity induced by a variety of environmental and chemical agents. It is thus important to understand the mechansims of hepatotoxicity for devising pharmacological strategies for their prevention. Inflammation, immunomodulation and oxidative stress are amongst the common biological mechanisms contributing to compromised liver function. A variety of drugs and chemicals are used to experimentally induce liver damage, which are assessed in the laboratory by physiological, biochemical and pathological biomarkers. Potential hepatoprotective agents are screened for efficacy and safety by observing their effects on these preclinical models, and their utility in clinical conditions are predicted. Several agents are reported to protect the liver from toxic insults and both synthetic and natural products are known to produce ameliorative effects both prophylactic and therapeutic. Medicinal plants are important alternative/ complimentary sources for potential hepatoprotective agents, and their efficacy and safety have been documented in both experimental and clinical studies. The present overview summarizes some of the basic concepts involved in hepatotoxicity, their preclinical evaluation methods and some relevant herbal hepatoprotective strategies.
Changes of Lower Limb Kinematics during 2000m Ergometer Rowing among Male Junior National Rowers

cycle was interpolated to 100 time points separately. The lower limb joint kinematics were compared across every 500m sections to evaluate its changes during 2000m rowing trial. There was a statistically significant difference between stroke rates for every 500m of 2000m rowing trial as determined by one-way ANOVA (F(3,36) = 4.880, p = 0.006). Kinematical variabilities were observed across splits particularly in frontal and transverse planes of lower limb joints. ABSTRACT Rowing involves cyclic motions that have a number of similar repetitions of joint excursion. Similar movement patterns, physiological, muscular activity and biomechanical aspects were observed while rowing on dynamic ergometer and on water. The purpose of our study is to evaluate the changes of lower limb kinematics during 2000m rowing on dynamic ergometer among male junior national rowers. Ten male junior national-level rowers participated in the study.
Traitement de l’insuffisance cardiaque diastolique

Au cours de cette derniere decennie, la comprehension de la physiopathologie de l’insuffisance cardiaque diastolique a considerablement progresse. L’epidemiologie et le diagnostic de cet autre visage de l’insuffisance cardiaque sont aujourd’hui mieux cernes. Cependant, le traitement de fond de l’insuffisance cardiaque diastolique est empirique car on ne dispose que de tres peu d’essais randomises dedies a cette entite. Seuls 2 essais therapeutiques visant a evaluer l’efficacite d’un bloqueur du systeme renine-angiotensine-aldosterone (candesartan, perindopril) ont jusqu’a ce jour ete publies. Les resultats de ces essais sont decevants sur le pronostic vital mais n’ecartent pas l’eventualite d’un benefice tire de ces molecules dans cette indication. La strategie therapeutique actuelle est fondee sur la prevention des recidives des poussees d’insuffisance cardiaque. Il s’agit ainsi de proposer et de renforcer les traitements specifiques des etiologies (cardiopathies hypertensives et ischemiques, le plus souvent). Le traitement des facteurs declenchants est tout aussi essentiel dans la prevention des poussees d’insuffisance cardiaque et l’aggravation de la maladie. Les effets reconnus des medicaments utilises dans l’insuffisance cardiaque a fonction systolique alteree sur le remodelage ventriculaire gauche, sur la fibrose myocardique, sur l’allongement du temps de remplissage ventriculaire gauche, ou sur l’ischemie myocardique, suggerent un benefice potentiel de ces memes molecules dans l’insuffisance cardiaque a fonction systolique preservee. Les donnees actuellement disponibles sur le traitement specifique de l’insuffisance cardiaque diastolique sont limitees dans l’attente des resultats de grands essais therapeutiques dans cette indication.
Perfil sociodemográfico de las mujeres que denuncian maltrato de pareja en la ciudad de Cali

Violence perpetred by a pertner is a public health problem in addition to be considered a social problem. This research had as purpose to study women that denounce their situation rearding intimate partner violence in the presence of Comisarias de Familia. Objetive: (i) To describe sociodemographic characteristics of battered women; (ii) To describe family histores of intimate partner violence of battered women, and (iii) to describe personal characteristics of battered women. Methodology: the research desing was cross-sectional by survey; the convenience sample was composed dof women that go to "Family Comissaries" to expose their partner violence situation in Cali, Colombia. The instrument applied was a questionnaire about sociodemographic and personal data applied by personal interview. The study had approval by Institutional Review Board - Ethic Committee. Results: The sample was 100 women, it was observed that the majority of women belongs to low socioeconomic strata, with low family income, low education; 12% unemployed, 43% were housewives; most of them with children, 44% with antecedents of family violence, 40% with intimate partner violence in a former intimate relationship. Discussion: Finding are compared with results from National Survey on Demography and Health for Colombia, with data for Cali; it is presented implications for health, education, wellbeing, justice sectors and for nursing practice.
ESTIMATION OF THE PHILLIPS CURVE , THE CASE OF THE CZECH REPUBLIC Ondřej Šimpach

The aim of this study is to assess the potential relationship between inflation and unemployment rate in the Czech Republic in light of Phillips curve approach. In some countries the assumptions of use of Phillips curve proved to perform very well, however this is not always the case. Since the Czech Republic is a young economy with lack of data available, causal relationship might not be necessarily valid for all years. This paper aims to analyze whether the assumptions of Phillips curve are limited in their effect or not with latest data set. In addition, forecasts of inflation and unemployment rate will be calculated using the Phillips curve and subsequently compared with the predictions resulting from the ARIMA model approach.
Poverty Reduction in Urban China : The Impact of Cash Transfers

The extent to which social protection programs in general and targeted programs in particular actually alleviate poverty has been a central issue in development debates for decades. The objective of this paper is to contribute to the debate by empirically examining the poverty-alleviation effects of one of the largest targeted programs in the world: the Minimum Living Standard Assistance (MLSA) or Dibao in China. Using newly available data on MLSA spending and a unique panel survey dataset covering the 19932009 period, this research investigates the impact of the MLSA on poverty alleviation. The analyses using fixedand randomeffects logit models and hierarchical liner models offer insights that go beyond the existing studies on the subject. Findings from the study confirm that targeted social protection programs are an effective tool for reducing poverty.
Chronic Obstructive Pulmonary Disease and Diabetes Mellitus

The progressive increase in the average age of the population leads to chronic diseases that are increasingly important. Chronic conditions are large in number, the prevalence of each one is high and so does the annual cost of their care. Moreover, clinicians alert about the impact of one disease on the development and severity of others. Among chronic morbidities the most prevalent are cardiovascular disease (CV), cancer, diabetes mellitus (DM) and chronic obstructive pulmonary disease (COPD) (Chillon et al., 2009). Noticeably, a 25% of patients older than 65 years have two chronic conditions and this figure rises to 40% in population over 75 years old (Chatila et al., 2008).
To study the effect of site and size of tympanic membrane perforation on graft uptake rates and hearing improvement in type I tympanoplasty using sliced conchal cartilage reinforced with temporalis muscle fascia and temporalis muscle fascia alone

Aim: To study the effect of site and size of tympanic membrane perforation on graft uptake rates and hearing improvement in Type I tympanoplasty using sliced conchal cartilage reinforced with temporalis muscle fascia and temporalis muscle fascia alone. Materials and Methods: In this retrospective study, a total of forty patients presenting with dry central perforation with intact and mobile ossicular chain and conductive type of hearing loss, visiting the ENT outpatient department of Government Medical College, Amritsar, were included. They were randomly divided into two groups of twenty patients each, with Group I patients undergoing Type I tympanoplasty with temporalis muscle fascia and Group II patients with sliced conchal cartilage as graft reinforced with temporalis fascia. A pure-tone audiometry (PTA) was done within 1 week prior to the surgery and at 3 months postoperatively to evaluate the hearing status. Results: Overall graft uptake rate in Group I was 85%, whereas that in Group II was 95% (P < 0.01). In Group I, graft uptake rate for small perforations was 100%, for medium 85.71%, subtotal 80%, and big central 66.66%. However, Group II graft uptake rates were 100% in all sizes except in medium-sized perforations (83.33%). The air–bone gap gain in Groups I and II was 14.91 (standard deviation [SD] ±9.741) and 14.48 (SD ± 9.366), respectively (P > 0.05). The hearing improvement was statistically insignificant between anterior and posterior perforations. Conclusion: From this study, we observed that size of the perforation is a major factor that influences graft uptake and hearing improvement results in Type I tympanoplasty using reinforced sliced conchal cartilage. Site of perforation failed to be a statistically significant influencing factor in this study.
Visual Working Memory for Faces and Facial Expressions as a Useful “Tool” for Understanding Social and Affective Cognition

Visual working memory (VWM) is one of the most investigated cognitive systems functioning as a hub between low- and high-level processes. Remarkably, its role in human cognitive architecture makes it a stage of crucial importance for the study of socio-affective cognition, also in relation with psychopathology such as anxiety. Among socio-affective stimuli, faces occupy a place of first importance. How faces and facial expressions are encoded and maintained in VWM is the focus of this review. Within the main theoretical VWM models, we will review research comparing VWM representations of faces and of other classes of stimuli. We will further present previous work investigating if and how both static (i.e., ethnicity, trustworthiness and identity) and changeable (i.e., facial expressions) facial features are represented in VWM. Finally, we will examine research showing qualitative differences in VWM for face representations as a function of psychopathology and personality traits. The findings that we will review are not always coherent with each other, and for this reason we will highlight the main methodological differences as the main source of inconsistency. Finally, we will provide some suggestions for future research in this field in order to foster our understanding of representation of faces in VWM and its potential role in supporting socio-affective cognition.
TCR Fingerprinting and Off-Target Peptide Identification

Adoptive T cell therapy using patient T cells redirected to recognize tumor-specific antigens by expressing genetically engineered high-affinity T-cell receptors (TCRs) has therapeutic potential for melanoma and other solid tumors. Clinical trials implementing genetically modified TCRs in melanoma patients have raised concerns regarding off-target toxicities resulting in lethal destruction of healthy tissue, highlighting the urgency of assessing which off-target peptides can be recognized by a TCR. As a model system we used the clinically efficacious NY-ESO-1-specific TCR C259, which recognizes the peptide epitope SLLMWITQC presented by HLA-A*02:01. We investigated which amino acids at each position enable a TCR interaction by sequentially replacing every amino acid position outside of anchor positions 2 and 9 with all 19 possible alternative amino acids, resulting in 134 peptides (133 altered peptides plus epitope peptide). Each peptide was individually evaluated using three different in vitro assays: binding of the NY-ESOc259 TCR to the peptide, peptide-dependent activation of TCR-expressing cells, and killing of peptide-presenting target cells. To represent the TCR recognition kernel, we defined Position Weight Matrices (PWMs) for each assay by assigning normalized measurements to each of the 20 amino acids in each position. To predict potential off-target peptides, we applied a novel algorithm projecting the PWM-defined kernel into the human proteome, scoring NY-ESOc259 TCR recognition of 336,921 predicted human HLA-A*02:01 binding 9-mer peptides. Of the 12 peptides with high predicted score, we confirmed 7 (including NY-ESO-1 antigen SLLMWITQC) strongly activate human primary NY-ESOc259-expressing T cells. These off-target peptides include peptides with up to 7 amino acid changes (of 9 possible), which could not be predicted using the recognition motif as determined by alanine scans. Thus, this replacement scan assay determines the “TCR fingerprint” and, when coupled with the algorithm applied to the database of human 9-mer peptides binding to HLA-A*02:01, enables the identification of potential off-target antigens and the tissues where they are expressed. This platform enables both screening of multiple TCRs to identify the best candidate for clinical development and identification of TCR-specific cross-reactive peptide recognition and constitutes an improved methodology for the identification of potential off-target peptides presented on MHC class I molecules.
Game-Based Training to Promote Arithmetic Fluency

The research team designed and evaluated a mobile game to promote rapid retrieval of arithmetic facts among a group of children aged 7–8 years (n = 97). The design of the game was based on principles drawn from research literature in mathematical cognition, game-based learning, and game design. The game trains basic number knowledge within a motivating context. It tested an implication of theory of automatization of arithmetic facts that training of recognition of multiples of single-digit numbers should lead to greater fluency in solving multiplication and division problems. A quasi-experimental design was employed to test whether the game improves retrieval of arithmetic facts. Children played the game in their classrooms for 20 min a day for 2 weeks. Comparisons between pre- and post-tests showed that the game playing group outperformed controls with a medium to large effect size (>0.6). These results suggest an improvement in arithmetic fluency equivalent to around 7 months' progress and provide rare empirical evidence supporting transfer of game-based training to a pencil-and-paper test. The findings are consistent with a connectionist theory of arithmetic skill, by showing that improved recognition of multiples contributes to multiplication and division skill. The theoretical and practical implications of these findings are discussed.