Miracle-dz/UniFAR-FTUs huggingface dataset:
Is Enough as good as a Feast? Examining the Relationship between Workaholism and Work-Family (WFC)/Family-Work (FWC) Conflict

Nowadays, people combine work and family roles more than they used to do before. Workaholics spend large amounts of time at work, work excessively hard, and become obsessed with work. Workaholism can be conceptualized as an addiction like alcoholism. But, what happens to workaholics’ family when they live with work not with them? Workaholics will neglect their family life under the works in their mind. Therefore, the purpose of this study was to investigate the relationship between workaholism and work-family (WFC) / family-work (FWC) conflict. A self-report questionnaire that included measures of the key constructs was completed by a sample of 339 banking employees. Correlation analysis and regression analysis were conducted to test the proposed hypotheses of the study. Whereas, FWC was unrelated to workaholism, WFC showed a positive correlation with workaholism. Furthermore, both work enjoyment and drivenness, on the workaholism facet, showed positive correlations with WFC. However, when all predictors of workaholism were entered in a regression analysis, only drivenness predicted WFC positively.
Gamma interferon reverses inhibition of leukocyte bactericidal activity by a 25-kilodalton fraction from Mycobacterium tuberculosis

In this study we examined the effects of Mycobacterium tuberculosis cell extracts on the phagocytic activity of polymorphonuclear leukocytes and cultured peripheral blood monocytes. M. tuberculosis cell extracts were fractionated on Sephacryl S-200 columns, and a 25-kilodalton glycolipoprotein was shown to inhibit the intracellular killing ability of these leukocytes but had no effect on their phagocytic potential. This same fraction inhibited fusion of phagosomes with lysosomes, as assessed by noting the transfer of acridine orange from lysosomes to phagosomes. This fraction was shown to have a maximal inhibitory effect when it was in the form of an intact carbohydrate-lipid-protein complex. Gamma interferon (IFN-gamma), but not IFN-alpha, reversed the inhibitory effect of the mycobacterial component on bactericidal activity and on fusion of phagosomes and lysosomes. Thus, this 25-kilodalton fraction of M. tuberculosis cell extract may be important in protecting organisms against phagocytic degradation, an effect which can be reversed by IFN-gamma.
Frequency of the Fc gamma RIIIA-158F allele in African American patients with systemic lupus erythematosus.

OBJECTIVE Defects in genes involved in immune complex clearance constitute one of the most common gene defects identified in patients with systemic lupus erythematosus (SLE). Defects in early complement components, complement receptors, and Fc receptors have all been implicated in the susceptibility to SLE. Recently, the role of functionally relevant Fc receptor polymorphisms in the etiology of SLE has been investigated. Specifically, a polymorphism of FC gamma RIII, termed Fc gamma RIIIA-158F, has been found to be associated with SLE in 2 largely Caucasian populations and appeared to constitute a risk factor for nephritis. We investigated the association of the Fc gamma RIIIA-158F and Fc gamma RIIIA-131R polymorphisms with SLE in an African American study population. METHODS Nested polymerase chain reaction (PCR) and allele-specific PCR was used to genotype patients with SLE and controls. RESULTS There was no difference in Fc gamma RIIIA-158F or Fc gamma RIIA-131R gene frequencies in the SLE populations compared to controls. There was no significant association between Fc gamma RIIIA-158F or Fc gamma RIIA-131R and any specific clinical or laboratory variable. CONCLUSION In our African American study population, there did not appear to be any association of Fc gamma RIIA-158F or Fc gamma RIIA-131R with SLE.
Knockdown of Parhyale Ultrabithorax recapitulates evolutionary changes in crustacean appendage morphology

Crustaceans possess remarkably diverse appendages, both between segments of a single individual as well as between species. Previous studies in a wide range of crustaceans have demonstrated a correlation between the anterior expression boundary of the homeotic (Hox) gene Ultrabithorax (Ubx) and the location and number of specialized thoracic feeding appendages, called maxillipeds. Given that Hox genes regulate regional identity in organisms as diverse as mice and flies, these observations in crustaceans led to the hypothesis that Ubx expression regulates the number of maxillipeds and that evolutionary changes in Ubx expression have generated various aspects of crustacean appendage diversity. Specifically, evolutionary changes in the expression boundary of Ubx have resulted in crustacean species with either 0, 1, 2, or 3 pairs of thoracic maxillipeds. Here we test this hypothesis by altering the expression of Ubx in Parhyale hawaiensis, a crustacean that normally possesses a single pair of maxillipeds. By reducing Ubx expression, we can generate Parhyale with additional maxillipeds in a pattern reminiscent of that seen in other crustacean species, and these morphological alterations are maintained as the animals molt and mature. These results provide critical evidence supporting the proposition that changes in Ubx expression have played a role in generating crustacean appendage diversity and lend general insights into the mechanisms of morphological evolution.
The flagellar hierarchy of Rhodobacter sphaeroides is controlled by the concerted action of two enhancer‐binding proteins

The expression of the bacterial flagellar genes follows a hierarchical pattern. In Rhodobacter sphaeroides the flagellar genes encoding the hook and basal body proteins are expressed from σ54‐dependent promoters. This type of promoters is always regulated by transcriptional activators that belong to the family of the enhancer‐binding proteins (EBPs). We searched for possible EBPs in the genome of R. sphaeroides and mutagenized two open reading frames (ORFs) (fleQ and fleT), which are in the vicinity of flagellar genes. The resulting mutants were non‐motile and could only be complemented by the wild‐type copy of the mutagenized gene. Transcriptional fusions showed that all the flagellar σ54‐dependent promoters with exception of fleTp, required both transcriptional activators for their expression. Interestingly, transcription of the fleT operon is only dependent on FleQ, and FleT has a negative effect. Both activators were capable of hydrolysing ATP, and were capable of promoting transcription from the flagellar promoters at some extent. Electrophoretic mobility shift assays suggest that only FleQ interacts with DNA whereas FleT improves binding of FleQ to DNA. A four‐tiered flagellar transcriptional hierarchy and a regulatory mechanism based on the intracellular concentration of both activators and differential enhancer affinities are proposed.
CPLD based power management system for low power devices

Energy is a precious resource in Wireless Sensor Nodes. With each transmission/reception and computation, energy is being expended and batteries get drained which can result in premature death of nodes and thereby reduced life span of WSN. The problem gets critical when the network is implemented under harsh environmental conditions like forests. Thus energy harvesting from environment becomes an important concern. In this paper, a design is presented for the development of power management system in an energy constraint device like wireless sensor node. The design presented utilizes solar energy to improve the efficiency and extend the duration of operation for sensor nodes. Experimental setup comprises of a PV based array simulator and a CPLD based power management module.
Robust stabilization and robust H∞ control of uncertain delta operator systems

For uncertain discrete time systems described by Delta operator, robust stabilization problem and H∞ control problem are discussed. Based on the conception of quadratic stability and quadratic stabilization, linear matrix inequality method is applied to design robust stabilizers, and robust H∞ controllers in the cases where external disturbances exist. All the results are presented in a set of linear matrix inequalities, which facilitates the design of controllers.
Dynamic treatment allocation adjusting for prognostic factors for more than two treatments.

Methods of sequential allocation of one of K treatments to patients, while controlling for important prognostic factors, are developed and compared. We focus on methods that are based on optimality theory (Begg and Iglewicz, 1980, Biometrics 36, 81-90; Atkinson, 1982, Biometrika 69, 61-67), the permuted block procedure (Zelen, 1974, Journal of Chronic Diseases 27, 365-375), and the compromise method (Faraggi and Reiser, 1991, Communication in Statistics, Simulation and Computation 20, 243-254). These methods are extended to the K treatments case and are evaluated in terms of efficiency and balance. It is shown that each method achieved the best results in the criterion it was designed to optimize, i.e., within stratum balance for the permuted block allocation and efficiency for the allocations that are based on optimality theory, but did not do well with other criteria. The compromise method, on the other hand, has good overall properties in terms of both balance and efficiency.
Determinants of Investment in Fixed Assets in Electric Power Industry - An Econometric Analysis

— This paper focuses attention on specific aspects of entrepreneurial decisions relating to investment, both in the total fixed investments and plant & machinery (separately). Demand and financial factors, internal and external, are considered in the investment analysis. Finally the influence of determinants of fixed investment and investment plans are examined in Electric Power industry in India.
THE UNIVERSITY OF CHICAGO HERMETIC: PRIVACY-PRESERVING DISTRIBUTED ANALYTICS WITHOUT (MOST) SIDE CHANNELS A THESIS SUBMITTED IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT OF COMPUTER SCIENCE BY MIN XU

Distributed analytics systems, such as Spark, enable users to efficiently perform computations over large distributed data sets. Recently, a number of systems have been proposed that can additionally protect the privacy of the data, by keeping it encrypted even in memory, and by performing the computations using trusted hardware features, such as Intel’s SGX. This approach is attractive because it makes it much safer to outsource computations, e.g., to an untrusted cloud platform. However, existing solutions remain vulnerable to a variety of side channels, such as timing, message sizes, and cache contents, which considerably weakens the privacy guarantees that these systems can effectively provide. In this paper, we present a principled approach to closing or mitigating the most critical side channels. We introduce a new primitive that can perform simple computations on a “locked-down core”, without externally visible side effects, as well as several enhanced oblivious algorithms that can use this primitive to answer more complex queries over large data sets. To preserve efficiency and to enable optimizations, we allow our algorithms to carefully disclose a small amount of information via differentially private queries. We present the design of a system called Hermetic that uses our techniques to answer SQL-style queries; our experimental evaluation of a Hermetic prototype shows that it is competitive with previous privacy-preserving systems, even though it provides stronger privacy guarantees.
A Low Cost Drive Current Enhancement Technique Using Shallow Trench Isolation Induced Stress for 45-nm Node

This paper demonstrates, for the first time, that sub-atmospheric chemical vapour deposition (SACVD) oxide is a good candidate for 45-nm node as shallow trench isolation (STI) gap-fill as well as a mobility enhancement technique for both lang100rang and lang110rang channel orientations. Respectively, 11% and 18% drive current enhancement for NMOS and PMOS transistors as well as a 12% ring oscillator speed improvement compared to a conventional high density plasma (HDP) process are reported
Cells From Different Regions of the Intervertebral Disc: Effect of Culture System on Matrix Expression and Cell Phenotype

Study Design. This study examined how the culture system and region of cellular origin affect disc cell morphology and extracellular matrix production. Objective. To determine the role of the cell populations in the different regions of the adult intervertebral disc in maintaining gradients in composition across the disc. Summary of Background Data. It is not known whether the steep profiles in composition across the intervertebral disc are maintained by distinct cell populations or whether differences in cell metabolism are determined by changes in the physical environment across the disc. Very little information exists on the matrix produced by cells from the mature, non-notochordal nucleus pulposus. Methods. Cells were extracted from articular cartilage, nucleus pulposus, and the inner and outer anulus fibrosus of caudal discs from 18- to 24-month-old steers cultured in alginate or collagen gels or in monolayer. The effect of culture system and cell origin on cell morphology and matrix synthesis was measured using 35S-sulphate labeling and indirect immunolocalization. Results. Distinct morphologic differences between cells from different regions cultured in monolayer were retained through two passages. The rate of sulfate incorporation varied with cell type. Immediately after isolation, it was two- to threefold greater for nucleus cells than for cells from the disc inner anulus or articular cartilage. The rate was lowest for outer anulus cells. It also varied with culture system. For all cell types, the incorporation rate was highest in alginate and lowest in monolayer. Immunolocalization showed that nucleus cells stained strongly for all proteoglycan epitopes, whereas outer anulus cells stained least and in monolayer produced little proteoglycan. Conclusions. The disc has at least three distinct cell populations, which differ in morphology and in amount and type of matrix they produce. Cells from mature nucleus pulposus produced sulfated glycosaminoglycans at a high rate in contrast to reported results for notochordal nucleus cells. Alginate, although an appropriate culture system for inner anulus and nucleus cells, may not be a suitable medium for outer anulus cells.
Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell‐based sensor

To identify potent bioactive factors for in vivo tissue regeneration by comprehensive screening remains a challenge for regenerative medicine. Here we report the development of an ES cell‐based monitoring system for osteogenic differentiation, the identification of a potent combination of osteogenic genes using such a system, and an evaluation of its therapeutic potentials. ES cells were isolated from mice carrying a transgene expressing GFP driven by the 2.3 kb fragment of rat type I collagen α(1) promoter. Using these cells engineered to fluoresce on osteogenic differenti‐ation, we screened cDNA libraries and combinations of major osteogenesis‐related genes. Among them, the combination of constitutively active activin receptorlike kinase 6 (caALK6) and runt‐related transcription factor 2 (Runx2) was the minimal unit that induced fluorescence. The combination efficiently induced os‐teogenic differentiation in various cell types, including terminally differentiated nonosteogenic cells. The cooperative action of the combination occurred through protein stabilization of core binding factor beta (Cbfb), induction of Runx2‐Cbfb complex formation, and its DNA binding. Furthermore, transplantation of a mono‐layer sheet of fibroblasts transduced with the combination achieved bone regeneration within 4 wk in mouse calvarial bone defects. Thus, we successfully identified the potent combination of genes for bone regeneration, which helped broaden cell sources. —Ohba, S. , Ikeda, T. , Kugimiya, F. , Yano, F. , Lichtler, A. C. , Nakamura, K. , Takato, T. , Kawaguchi, H. , Chung, U. I. Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell‐based sensor. FASEB J. 21, 1777–1787 (2007)
Intermittent observation of time‐dependent explanatory variables: a multistate modelling approach

Motivated by investigations of factors related to various patient‐reported outcome measures in psoriatic arthritis patients, after controlling for the effect of disease activity on these outcomes, we outline an approach for dealing with a rapidly fluctuating explanatory variable in a multistate model. On the basis of a representation of this variable as an ordinal classification, we suggest the use of an expanded multistate model. We examine the bias in estimating effects associated with other variables via simulation for different modelling choices. We present an analysis of a motivating data set on physical functional disability in psoriatic arthritis patients. Copyright © 2011 John Wiley & Sons, Ltd.
Virus-specific antiviral treatment for controlling severe and fatal outbreaks of feline calicivirus infection.

OBJECTIVE To test the life-sparing and therapeutic effect of a parenterally administered virus-specific antiviral phosphorodiamidate morpholino oligomer (PMO) for treating kittens during outbreaks of severe viral disease. ANIMALS 112 kittens of various sex and age in 4 trials involving 3 outbreaks of naturally developing caliciviral disease. PROCEDURES Each trial provided an opportunity to investigate the disease. A calicivirus isolated from the liver of a cat that died with hemorrhage and hepatitis was sequenced, and a PMO that had sequence specificity complementary to a 5' region was synthesized. In vitro efficacy of the PMO was tested against the isolate, followed by 3 trials in outbreaks of severe caliciviral disease. The PMO was administered starting on day 1 of disease onset (0.7 to 5.0 mg/kg, SC, q 24 h) and continuing for up to 7 days. Survival time, clinical recovery, and caliciviral shedding were compared by use of various antiviral dosages. In a fourth trial involving nonfatal disease, a control treatment was administered for comparison. RESULTS In vitro blockage of caliciviral replication by the PMO was dose dependent. In trials 1 to 3 in which survival was the endpoint, 47 of 59 cats receiving PMO survived but only 3 of 31 survived without PMO treatment. Antiviral treatment reduced viral shedding and hastened clinical recovery, as measured by weight gains and clinical condition. CONCLUSIONS AND CLINICAL RELEVANCE These data provided evidence that virus-specific PMOs were effective in treating kittens with severe Vesivirus disease and suggested a broader application for other viruses and species, including humans.
WHY SHOULD LEK‐BREEDERS BE MONOMORPHIC?

Approximately one‐quarter of all lek‐breeding bird species are sexually monomorphic. Understanding the significance, if any, of this exception to the usual correlation between sexual selection and dimorphism requires detailed data on the mating systems of both monomorphic and dimorphic species. The capuchinbird (Perissocephalus tricolor) is a sexually monomorphic, lek‐breeding member of the cotinga family. I studied the social and sexual behavior of this species, and compared it with the Guianan cock‐of‐the‐rock (Rupicola rupicola), a dimorphic, lekking member of the same family.
Glycemic control and cardiovascular mortality

Purpose of reviewDiabetes mellitus is associated with several-fold increased risk of cardiovascular events, including death, yet whether treatment of hyperglycemia can reduce this risk remains controversial. Recent findingsEpidemiologic associations between hyperglycemia and cardiovascular risk have been confirmed and extended to levels below those diagnostic of diabetes. Long-term follow-up of treatment early in diabetes suggests benefits may lag 10 years or more after initiation of treatment. Intensive glycemic treatment of high-risk persons with current methods may increase short-term mortality. SummaryFurther analyses of existing data to define high-risk and lower-risk subgroups of patients may allow revision of treatment guidelines. Future studies may begin early in diabetes, require long-term follow-up, and use improved methods of treatment.
Control of nonlinear systems with partial state constraints using a barrier Lyapunov function

This article addresses the problem of control design for strict-feedback systems with constraints on the states. To prevent the states from violating the constraints, we employ a barrier Lyapunov function (BLF), which grows to infinity whenever its arguments approaches some finite limits. Based on BLF-based backstepping, we show that asymptotic output tracking is achieved without violation of any constraint, provided that the initial states and control parameters are feasible. We also establish sufficient conditions to ensure feasibility, which can be checked offline without precise knowledge of the initial states. The feasibility conditions are relaxed when handling the partial state constraint problem as compared to the full state constraint problem. In the presence of parametric uncertainties, BLF-based adaptive backstepping is useful in preventing the states from transgressing the constrained region during the transient stages of online parameter adaptation. To relax the feasibility conditions, asymmetric error bounds are considered and asymmetric barrier functions are used for control design. The performance of the BLF-based control is illustrated with two simulated examples.
School-Based Mental Health Programming for Children With Inattentive and Disruptive Behavior Problems: First-Year Treatment Outcome

This article examines the effectiveness of an evidence-based behavioral treatment package for children with inattentive and disruptive behavior problems when delivered in the context of a school-based mental health program. Child symptomatology and functioning are assessed in a treatment group (n = 30) and a waitlist control group (n = 12) across multiple time points (fall, winter, and spring). Treatment includes a daily report card procedure, year-long teacher consultation, and parenting sessions. According to the parent report, treated children show marked reductions in hyperactive and impulsive, oppositional or defiant and aggressive behavior, and marked improvement in peer relationships. Teachers observe treatment-related group differences in inattention, academic functioning, and the student-teacher relationship. Feasibility and acceptability data have implications for transporting evidence-based treatments to community settings and for integrating mental health services into the culture of the school community.