Miracle-dz/UniFAR-FTUs huggingface dataset:
DINAMIKA PEMANFAATAN LAHAN PADA KAWASAN PERBUKITAN KASUS DAS SERANG KULON PROGO

Dinamika pemanfaatan lahan khususnya pada kawasan perbukitan ( upland area ) cenderung membawa dampak pada degradasi lingkungan, dan itu merupakan ancaman serius bagi kehidupan masa kini dan bagi generasi mendatang. Gagalnya pengembangan teknologi usahatani konservasi di pedesaan lahan kering perbukitan dan dataran tinggi dapat dipandang sebagai gagalnya upaya perbaikan lingkungan dan khususnya kawasan perbukitan. Hal ini dapat dimaknai sebagai semakin mendekatnya ancaman terhadap kehidupan masyarakat secara keseluruhan, terutama masyarakat pedesaan. Sementara itu, sumberdaya alam terutama lahan yang tersedia sangat terbatas, sehingga apabila dalam pemanfaatannya tidak disertai dengan upaya-upaya untuk mempertahankan fungsi dan kemampuannya akan dapat menimbulkan kerusakan dan mengancam kelestarian sumberdaya lahan tersebut. Pola pemanfaatan lahan pada kawasan perbukitan ( upland area ) umumnya berupa kebun campuran; kebun sejenis, permukiman, hutan dan semak belukar; persawahan dan palawija. Pola-pola pemanfaatan lahan tersebut cenderung mengalami perubahan dari waktu kewaktu. Pola-pola perubahan pemanfaatan lahan dipengaruhi oleh dinamika geobiofisik lahan, sosial budaya, dan social ekonomi. Keterkaitan hubungan di antara faktor-faktor di muka dalam pemanfaatan lahan akan berdampak pada gradasi ekologis yang bervaraisi. Kata kunci : dinamika pemanfaatan lahan, kawasan perbukitan, degradasi lingkungan
Cluster-based Contextual Recommendations

In this work, we address the problem of contextual recommendations by exploiting the concept of subspace clustering. Specifically, we pre-partition users that have rated subsets of data items similarly into clusters and we associate a context situation with each cluster. The cluster context is defined as any internally stored information that can be used to characterize the cluster members per se. Then, given a query context, we identify the clusters with the most similar context, and we use their members for making suggestions in a collaborative filtering manner.
The TEA Set: Tacit Knowledge and Scientific Networks

INTRODUCTION: METHODOLOGICAL AND THEORETICAL ARGUMENT Thomas Kuhn's concept of 'paradigm" has attracted a lot of attention from sociologists and historians of science. In particular, some recent work has involved the search for groups of scientists which are taken to be the social analogue of this idea. I will argue here that the boundaries of those 'social circles' of scientists which have been found are not likely to correspond with the boundaries of groups sharing a paradigm unless the term be construed in a restricted sense. This is because the research methods used in most cases are unsuitable for the investigation of cognitive specificity and discontinuity. But it is precisely because paradigm groups are seen as conceptually homogeneous and bounded that the idea has excited interest in the sociology of science as a branch of the sociology of knowledge. An impressive number of studies2 have been published which try to show
Use of Twice-Daily Exenatide in Basal Insulin–Treated Patients With Type 2 Diabetes

BACKGROUND Insulin replacement in diabetes often requires prandial intervention to reach hemoglobin A₁(c) (HbA₁(c)) targets. OBJECTIVE To test whether twice-daily exenatide injections reduce HbA₁(c) levels more than placebo in people receiving insulin glargine. DESIGN Parallel, randomized, placebo-controlled trial, blocked and stratified by HbA₁(c) level at site, performed from October 2008 to January 2010. Participants, investigators, and personnel conducting the study were masked to treatment assignments. (ClinicalTrials.gov registration number: NCT00765817) SETTING 59 centers in 5 countries. PATIENTS Adults with type 2 diabetes and an HbA₁(c) level of 7.1% to 10.5% who were receiving insulin glargine alone or in combination with metformin or pioglitazone (or both agents). INTERVENTION Assignment by a centralized, computer-generated, random-sequence interactive voice-response system to exenatide, 10 µg twice daily, or placebo for 30 weeks. MEASUREMENTS The primary outcome was change in HbA₁(c) level. Secondary outcomes included the percentage of participants with HbA₁(c) values of 7.0% or less and 6.5% or less, 7-point self-monitored glucose profiles, body weight, waist circumference, insulin dose, hypoglycemia, and adverse events. RESULTS 112 of 138 exenatide recipients and 101 of 123 placebo recipients completed the study. The HbA₁(c) level decreased by 1.74% with exenatide and 1.04% with placebo (between-group difference, -0.69% [95% CI, -0.93% to -0.46%]; P < 0.001). Weight decreased by 1.8 kg with exenatide and increased by 1.0 kg with placebo (between-group difference, -2.7 kg [CI, -3.7 to -1.7]). Average increases in insulin dosage with exenatide and placebo were 13 U/d and 20 U/d. The estimated rate of minor hypoglycemia was similar between groups. Thirteen exenatide recipients and 1 placebo recipient discontinued the study because of adverse events (P < 0.010); rates of nausea (41% vs. 8%), diarrhea (18% vs. 8%), vomiting (18% vs. 4%), headache (14% vs. 4%), and constipation (10% vs. 2%) were higher with exenatide than with placebo. LIMITATIONS The study was of short duration. There were slight imbalances between groups at baseline in terms of sex, use of concomitant glucose-lowering medications, and HbA₁(c) levels, and more exenatide recipients than placebo recipients withdrew because of adverse events. CONCLUSION Adding twice-daily exenatide injections improved glycemic control without increased hypoglycemia or weight gain in participants with uncontrolled type 2 diabetes who were receiving insulin glargine treatment. Adverse events of exenatide included nausea, diarrhea, vomiting, headache, and constipation. PRIMARY FUNDING SOURCE Alliance of Eli Lilly and Company and Amylin Pharmaceuticals.
Efficiency Study of Vertical Distance Variations in Wireless Power Transfer for E-Mobility

A wireless power transfer (WPT) system is a safe, convenient, and smart charging solution for electric vehicle (EV) users. However, a drawback of the WPT systems is the reduced efficiency in comparison to the conventional wired charging due to lower coupling. Increasing the volume of EVs in the market and improving the system efficiency even by a few percent, besides being environmentally suitable, will benefit both consumers and distributors. According to the previous studies, efficiency improvement by decreasing the vertical distance (VD) between transmitter (TX) and receiver (RX) coils has been one of the aims of the companies and universities. However, in low VD, system performance becomes highly sensitive, due to the magnetic coupling strength. The focus of this paper is to analyze the effects of decreasing the vertical distances to WPT resonance tank efficiencies. Finally, some of the most significant parameters that affect the system efficiency at low VD, such as the quality factor and the third harmonic interference, are analyzed and a mitigating approach is proposed.
Changes of PKA and PDK1 in the principal piece of boar spermatozoa treated with a cell‐permeable cAMP analog to induce flagellar hyperactivation

A cAMP‐induced protein tyrosine phosphorylation and flagellar hyperactivation are controlled via complicated signaling cascades in mammalian spermatozoa. For instance, these events seem to be regulated positively by the PKA‐mediated signaling and negatively by the PI3K/PDK1‐mediated signaling. In this article, we have shown molecular changes of PKA and PDK1 in cAMP analog (cBiMPS)‐treated boar spermatozoa in order to disclose possible roles of these kinases in protein tyrosine phosphorylation and hyperactivation. Ejaculated spermatozoa were incubated with cBiMPS, and then they were used for biochemical analyses of sperm kinases by Western blotting and indirect immunofluorescence and for assessment of flagellar movement. The first 30‐min incubation with cBiMPS highly activated PKA of the principal piece to the accompaniment of autophosphorylation on Thr‐197 of catalytic subunits. However, protein tyrosine phosphorylation and hyperactivation were fully induced in the sperm samples after the 180‐min incubation. A potentially active form of PDK1 (54/55‐kDa phospho‐PDK1) was detected in the principal piece of the spermatozoa during the 90‐min incubation. Another potentially active form (59‐kDa phospho‐PDK1) gradually increased during the same incubation period. However, the PDK1 suddenly became inactive by the dephosphorylation after the 180‐min incubation, namely coincidently with full induction of protein tyrosine phosphorylation and hyperactivation. Additionally, existence of PI3K‐dependently suppressing mechanisms for protein tyrosine phosphorylation was confirmed in the principal piece by pharmacological experiments with LY294002 and biochemical analyses with anti‐PI3K p85 antibodies. These findings suggest that dephosphorylation of PDK1 may be a molecular switch for enhancement of protein tyrosine phosphorylation and flagellar hyperactivation in boar spermatozoa. Mol. Reprod. Dev. 75: 1396–1407, 2008. © 2008 Wiley‐Liss, Inc.
Who lies?

Seventy-seven undergraduates and 70 demographically diverse members of the community completed 12 individual differences measures hypothesized to predict lie-telling in everyday life and then kept a diary every day for a week of all of their social interactions and all of the lies that they told during those interactions. Consistent with predictions, the people who told more lies were more manipulative, more concerned with self-presentation, and more sociable. People who told fewer lies were more highly socialized and reported higher quality same-sex relationships. Manipulative people, less highly socialized people, and people with less gratifying same-sex relationships also told especially more self-serving lies, whereas people with higher quality same-sex relationships told relatively more other oriented lies.
Breathing signal combining for respiration rate estimation in smart beds

One of the non-invasive ways to measure respiratory effort is in-bed pressure sensor arrays. Based on the area of the bed and the sensor array covered by a patient's body, some sensors may not include significant respiratory effort components or may have low signal to noise ratios. When combining signals from the different sensors, this can produce a low quality output signal. Signal combiners can overcome this problem. This paper describes two different methods of signal combining to achieve a good estimation of the respiratory rate and the respiratory signal itself. To assess the performance, a participant was asked to lay on the bed in supine position while having normal breathing. Our results indicate that both methods can perform very satisfactorily when compared to a gold standard signal, and that they can outperform some previously published methods.
Difference in myocardial flow reserve between patients with dilated cardiomyopathy and those with dilated phase of hypertrophic cardiomyopathy: evaluation by 15O-water PET.

BACKGROUND The clinical features of patients with the dilated phase of hypertrophic cardiomyopathy (DHCM) may resemble those of patients with dilated cardiomyopathy (DCM); that is, systolic dysfunction and left ventricular dilatation. Myocardial flow reserve (MFR) is impaired in patients with nonischemic cardiomyopathy, and the reduced MFR may be related to poor prognosis. Several studies report that the mortality rate for patients with DHCM is higher than for DCM, but the difference between these 2 cardiomyopathies is still unclear. The purpose of this study was to assess the MFR of these 2 cardiomyopathies, using (15)O-water positron emission tomography (PET) to elucidate their differences. METHODS AND RESULTS In total 30 patients were investigated: 23 with DCM (Group A) and 7 with DHCM (Group B). All those who were in a stable condition underwent cardiac catheterization. Myocardial blood flow (MBF) at rest and under ATP infusion was measured by (15)O-water PET, and the MFR was calculated. There were no significant differences in the hemodynamics of the 2 groups. The mean MFR in DHCM was significantly lower than that in DCM (1.49+/-0.31 vs 2.62+/-1.08; p=0.042), whereas MBF at rest did not differ (DCM vs DHCM: 0.66+/-0.20 vs 0.49+/-0.05 ml . min(-1) . g(-1); NS). The MFR in both Group A and B was significantly decreased compared with the normal controls (MFR in normal controls: 5.15+/-1.64, p=0.00015, 0.00013, respectively). CONCLUSIONS These results suggest that impaired vasodilatation (ie, dysfunction of the microcirculation) is more severe in patients with DHCM than in patients with DCM, even though patients' characteristics and hemodynamics do not differ.
Frugal calibration of mutual coupling in large scale antenna array

In a time-division duplexing (TDD) system, the uplink (UL) and downlink (DL) channel reciprocity gets impaired due to the mismatches of the antenna radio frequency (RF) electronics. Meanwhile, in massive multiple-input multiple-output (MIMO), as the antenna elements are placed close to each other, the mutual coupling effects among the adjacent antennas also become pronounced. Different coupling matrices for transmission and reception also hurt the end-to-end UL/DL channel reciprocity. Aiming to restore the end-to-end channel reciprocity with a small amount of over-the-air (OTA) resources, we propose to estimate the gain mismatches of the RF electronics and the mutual coupling mismatches separately. Specifically, we rely on the pilot exchanges among the BS antennas and the symmetry of the antenna array to recover the transmit and receive gains of all the RF components. Unlike prior calibration works, our schemes can recover the off-diagonal elements in the calibration matrix as well. Our designs are also corroborated with numerical simulations.
Successful treatment of recalcitrant malar rash in a patient with cutaneous lupus erythematosus with efalizumab

In a recent issue of Clinical and Experimental Dermatology, Lim and Foo reported a patient with chronic plaque psoriasis who developed disseminated molluscum contagiosum (MC) after methotrexate treatment. We agree with the authors suggestion that the diagnosis of MC should be considered in patients taking methotrexate who develop suspicious papules and speculate that the occurrence of MC in these patients may be a common, yet under-recognized phenomenon. A 69-year-old woman was referred with a 3-month history of slightly pruritic lesions on the face and neck. She had a 13-year history of disabling rheumatoid arthritis (RA) and had been on oral methotrexate 17.5 mg ⁄ week for 1.5 years and salazopyrin 1.5 g ⁄ day for 13 years. Clinical examination showed multiple discreet, flesh-coloured, crateriform papules, 2–5 mm in size, on the eyelids, cheeks and neck (Fig. 1). Few of these papules were excoriated. Haematological investigations including white cell and differential count were normal. A clinical diagnosis of MC was confirmed on histology. Owing to the disabling nature but reasonable control of her RA, and the rather localized and benign nature of the MC, her immunosuppressive treatment has not been interrupted. A trial of topical hydrogen peroxide 1% cream (Crystacide ; Bioglan, Hampshire, UK) is underway. MC is a benign eruption of umblicated papules caused by the molluscipox virus of the Poxviridae family, which is transmitted by direct contact. Although commonly selflimiting and usually occurring in children, difficult to treat and widespread MC infection can be encountered occasionally in patients with impaired cellular immunity. A few cases of disseminated MC infection occurring in patients immunosuppressed with azathioprine and mycophenolate mofetil have been described. There are several possible explanations for the relative paucity of reports of milder MC infection in iatrogenically immunosuppressed patients. As most cases are mild, these may not be brought to medical attention. Furthermore, iatrogenic immunosuppression is more commonly used as a therapeutic strategy by nondermatologists, who may not be familiar with this diagnosis. Finally, MC may subside without intervention even in the setting of immunosuppression. However, to avoid the risk of disseminated infection, MC in immunosuppressed patients should be actively treated.
The human skeletal muscle transcriptome: sex differences, alternative splicing, and tissue homogeneity assessed with RNA sequencing

Human skeletal muscle health is important for quality of life and several chronic diseases, including type II diabetes, heart disease, and cancer. Skeletal muscle is a tissue widely used to study mechanisms behind different diseases and adaptive effects of controlled interventions. For such mechanistic studies, knowledge about the gene expression profiles in different states is essential. Since the baseline transcriptome has not been analyzed systematically, the purpose of this study was to provide a deep reference profile of female and male skeletal muscle. RNA sequencing data were analyzed from a large set of 45 resting human muscle biopsies. We provide extensive information on the skeletal muscle transcriptome, including 5 previously unannotated protein‐coding transcripts. Global transcriptional tissue homogeneity was strikingly high, within both a specific muscle and the contralateral leg. We identified >23,000 known isoforms and found >5000 isoforms that differ between the sexes. The female and male transcriptome was enriched for genes associated with oxidative metabolism and protein catabolic processes, respectively. The data demonstrate remarkably high tissue homogeneity and provide a deep and extensive baseline reference for the human skeletal muscle transcriptome, with regard to alternative splicing, novel transcripts, and sex differences in functional ontology. —Lindholm, M. E. , Huss, M. , Solnestam, B. W. , Kjellqvist, S. , Lundeberg, J., Sundberg, C. J., The human skeletal muscle transcriptome: sex differences, alternative splicing, and tissue homogeneity assessed with RNA sequencing. FASEB J. 28, 4571–4581 (2014). www.fasebj. org
Motion interpretation for in-car vision systems

In this paper we consider a single camera attached to a moving vehicle. Based on the observations, we estimate the time-to-contact of vehicles around us. We propose three different approaches for the estimation of this parameter. The measurement input for these approaches respectively consists of: the horizontal position in the image plane of a point observed on a vehicle, the vertical position and the observed vehicle width. This measurement data can robustly be obtained in practice. It is possible to automatically select the approach that provides the most accurate result for a given situation. The influence of disturbances in the observations in practice is suppressed by means of temporal filtering. Due to the similar structure of the three approaches, the same temporal filtering technique can be applied. The practical value of the algorithms is illustrated by means of real video data.
Complete genome sequence of Atopobium parvulum type strain (IPP 1246T)

Atopobium parvulum (Weinberg et al. 1937) Collins and Wallbanks 1993 comb. nov. is the type strain of the species and belongs to the genomically yet unstudied Atopobium/Olsenella branch of the family Coriobacteriaceae. The species A. parvulum is of interest because its members are frequently isolated from the human oral cavity and are found to be associated with halitosis (oral malodor) but not with periodontitis. Here we describe the features of this organism, together with the complete genome sequence, and annotation. This is the first complete genome sequence of the genus Atopobium, and the 1,543,805 bp long single replicon genome with its 1369 protein-coding and 49 RNA genes is part of the GenomicEncyclopedia ofBacteria andArchaea project.
China's patterns of international technological collaboration 1976–2010: a patent analysis study

This study focuses on the trajectories and patterns of China's international collaborations over the period 1976–2010, using patent statistics and association analysis methods. The results identify those government policies that have significantly encouraged changes in the scale and scope of China's collaborations since 1997. The USA and Taiwan are major international collaborators with China, and the top cooperative entities are large-scale multi-national firms, which specialise in production, sales research and development of information or electronics technology; in contrast, universities and research institutions have a negligible presence in international collaborative patenting. This study finds that although China has developed significant international collaborative networks since the 1990s, it still needs to extend these ties to an even greater range of international partners and establish a broader scope of research interests.
Identification of a Candidate Human Spectrin Src Homology 3 Domain-binding Protein Suggests a General Mechanism of Association of Tyrosine Kinases with the Spectrin-based Membrane Skeleton*

Spectrin is a widely expressed protein with specific isoforms found in erythroid and nonerythroid cells. Spectrin contains an Src homology 3 (SH3) domain of unknown function. A cDNA encoding a candidate spectrin SH3 domain-binding protein was identified by interaction screening of a human brain expression library using the human erythroid spectrin (αI) SH3 domain as a bait. Five isoforms of the αI SH3 domain-binding protein mRNA were identified in human brain. Mapping of SH3 binding regions revealed the presence of two αI SH3 domain binding regions and one Abl-SH3 domain binding region. The gene encoding the candidate spectrin SH3 domain-binding protein has been located to human chromosome 10p11.2 → p12. The gene belongs to a recently identified family of tyrosine kinase-binding proteins, and one of its isoforms is identical to e3B1, an eps8-binding protein (Biesova, Z., Piccoli, C., and Wong, W. T. (1997)Oncogene 14, 233–241). Overexpression of the green fluorescent protein fusion of the SH3 domain-binding protein in NIH3T3 cells resulted in cytoplasmic punctate fluorescence characteristic of the reticulovesicular system. This fluorescence pattern was similar to that obtained with the anti-human erythroid spectrin αIΣI/βIΣI antibody in untransfected NIH3T3 cells; in addition, the anti-αIΣI/βIΣI antibody also stained Golgi apparatus. Immunofluorescence obtained using antibodies against αIΣI/βIΣI spectrin and Abl tyrosine kinase but not against αII/βII spectrin colocalized with the overexpressed green fluorescent protein-SH3-binding protein. Based on the conservation of the spectrin SH3 binding site within members of this protein family and published interactions, a general mechanism of interactions of tyrosine kinases with the spectrin-based membrane skeleton is proposed.