Miracle-dz/UniFAR-FTUs huggingface dataset:
A 4-Mb toggle MRAM based on a novel bit and switching method

A 4-Mb magnetoresistive random access memory (MRAM) with a novel magnetic bit cell and toggle switching mode is presented. The circuit was designed in a five level metal, 0.18-mum complementary metal-oxide-semiconductor process with a bit cell size of 1.55 mum2. The new bit cell uses a balanced synthetic antiferromagnetic free layer and a phased write pulse sequence to provide robust switching performance with immunity from half-select disturbs. This switching mode greatly improves the operational performance of the MRAM as compared to conventional MRAM. A detailed description of this 4-Mb toggle MRAM is presented
Pharmacological characterization of isolated human prostate.

PURPOSE Human prostate contains alpha-1 adrenergic, cholinergic and nonadrenergic noncholinergic neuroreceptors. Using agonistic and antagonistic agents at these neuroreceptors we studied the resultant contractile responses in isolated human prostate. MATERIALS AND METHODS Human prostate tissue was obtained at prostatectomy for benign prostatic hyperplasia in 37 adult male patients. Tissues were suspended in tissue bath chambers connected to force displacement transducers. Specimens were subjected to agonist induced contractions, the first always being norepinephrine (NE). Specimens were pretreated with antagonist (adrenergic, cholinergic, nonadrenergic noncholinergic or none if control), followed by contraction with a second agonist (NE or other). Contractile tensions were recorded on a polygraph and then statistically analyzed. RESULTS The order of highest to lowest agonist induced tensile forces was NE, dopamine, acetylcholine, bethanechol, histamine and serotonin. Excitatory concentration EC(50) values were determined for each agonist tested. Significant differences were found between specific alpha-1 adrenergic receptor blockers (terazosin, prazosin and the experimental drug LY253352). In addition, many other agents antagonized the alpha-1 adrenergic receptor. Inhibitory concentration IC(50) values were obtained and the order of alpha-1 adrenergic antagonistic strengths from strongest to weakest was LY253352, prazosin, terazosin, ketanserin, SCH23390, diphenhydramine, DO710, dopamine, serotonin and histamine. CONCLUSIONS Human prostate neuroreceptors were determined to be alpha-1 adrenergic, dopaminergic, muscarinic cholinergic, 2A serotonergic and H1 histaminergic. Dopamine, serotonin, histamine and their antagonists blocked the adrenergic response, indicating possible receptor-receptor interaction. Further study of the pharmacology of human prostate would likely identify new drugs for treating patients with bladder outlet obstruction due to benign prostatic hyperplasia.
Draft Genome Sequence of an Obligately Methylotrophic Methanogen, Methanococcoides methylutens, Isolated from Marine Sediment

ABSTRACT Methanococcoides methylutens, the type species of the genus Methanococcoides, is a slightly halophilic methanogenic archaeon with a methylotrophic metabolism. Here, we present the annotated draft genome sequence of M. methylutens, which comprises 2,508,511 bp with 2,482 coding sequences, 51 tRNA genes, and a G+C content of 42.5%.
Line‐Drawing Video Stylization

We present a method to automatically convert videos and CG animations to stylized animated line drawings. Using a data‐driven approach, the animated drawings can follow the sketching style of a specific artist. Given an input video, we first extract edges from the video frames and vectorize them to curves. The curves are matched to strokes from an artist's library, while following the artist's stroke distribution and characteristics. The key challenge in this process is to match the large number of curves in the frames over time, despite topological and geometric changes, allowing to maintain temporal coherence in the output animation. We solve this problem using constrained optimization to build correspondences between tracked points and create smooth sheets over time. These sheets are then replaced with strokes from the artist's database to render the final animation. We evaluate our tracking algorithm on various examples and show stylized animation results based on various artists.
On to the continuity of the map square root of nonnegative isomorphisms in Hilbert spaces

Let H be a real (or complex) Hilbert space. Every nonnegative operator $L \in L(H)$ admits a unique nonnegative square root $R \in L(H)$, i.e., a nonnegative operator $R \in L(H)$ such that $R^{2}= L$. Let $GL^{+}_{S}(H)$ be the set of nonnegative isomorphisms in $L(H)$. First we will show that $GL^{+}_{S}(H)$ is a convex (real) Banach manifold. Denoting by $L^{1/2}$ the nonnegative square root of $L$. In [10], Richard Bouldin proves that $L^{1/2}$ depends continuously on $L$ (this proof is non-trivial). This result has several applications. For example, it is used to find the polar decomposition of a bounded operator. This polar decomposition allows us to determine the positive and negative spectral subespaces of any self-adjoint operator, and moreover, allows us to define the Maslov index. The autor of the paper under review provides an alternative proof (and a little more simplified) that $L^{1/2}$ depends continuously on $L$, and moreover, he shows that the map \begin{align}R&: GL^{+}_{S}(H)\rightarrow GL^{+}_{S}(H)\\ L&\to L^{1/2} \end{align} is a homeomorphism.
A comprehensive well to wheel analysis of plug-in vehicles and renewable energy resources from cost and emission viewpoints

In recent years, greenhouse gas emission has become a critical issue for the international community. In this regard, transportation and electricity industries as main sources of this pollution have been taken into consideration widely. Increase in equipment's efficiency and using and developing new technologies such as Electric Vehicles (EVs), EVs with vehicle-togrid capability, referred to as “gridable vehicles” (GVs), and Renewable Energy Sources (RESs) are recommended as solutions for solving the emission problem. Charging EVs from grid increases grid load, especially the peak load. This increase in load will consequently increase the amount of energy losses, fuel cost of power generation, need for initial investment, and power plant emissions. Thus, to any decision making, it is important to study and analyze all important effective factors simultaneously. In this paper, EVs and RESs penetration in power system is investigated in terms of economics/environment. A multi-objective optimization is applied to a ten-unit system to find the optimal cost and well to wheel emission simultaneously. In order to have a more accurate and close to realistic survey, an extended model of Wind Farm (WF) cost function is employed in power dispatch calculations.
Detection of coded modulation signals on linear, severely distorted channels using decision-feedback noise prediction with interleaving

On linear bandlimited Gaussian noise channels with sufficiently high SNR, channel capacity can be approached by combining powerful coded modulation schemes designed for Nyquist channels with the equalization power of decision-feedback equalization (DFE). However, this combination may not be realized in a straightforward manner, since, in general, DFE requires delay-free decisions for feedback, and in a coded system such decisions are not sufficiently reliable. A technique is proposed that combines periodic interleaving with noise-predictive DFE, so that delayed reliable decisions can be used for feedback. When sufficient delay in the interleavers can be tolerated, this technique can attain the DFE performance. On severely distorted channels, modest delays can be sufficient to obtain respectable gains over linear equalization. >
Glucosylation of glycoproteins by mammalian, plant, fungal, and trypanosomatid protozoa microsomal membranes.

An assay for UDP-Glc:glycoprotein glucosyltransferase was developed. Incubation of rat liver microsomes with UDP-[14C]Glc led to the formation of hot trichloroacetic acid insoluble material identified as protein-linked Glc1Man7-9GlcNAc2. Addition of 8 M urea-denatured thyroglobulin to the incubation mixtures stimulated up to 10-12-fold the formation of the same compounds but only in the presence of detergents. Native thyroglobulin was ineffective. Several experiments indicated that the stimulation was due to the transfer of glucose residues from UDP-Glc to high-mannose oligosaccharides in urea-denatured thyroglobulin and that this transfer reaction did not involve dolichol mono- or diphosphate derivatives as intermediates. The glycoprotein glucosylating activity was mainly located in the endoplasmic reticulum and could glucosylate glycopeptides derived from the digestion of thyroglobulin with an unspecific protease. Glucosylation of oligosaccharides in those glycopeptides occurred, however, at a rate at least 2 orders of magnitude slower than that of the same compounds in urea-denatured thyroglobulin. Tryptic digestion of urea-denatured thyroglobulin did not affect its glucosylation rate. The structure of Glc1Man9GlcNAc2 linked to urea-denatured thyroglobulin was identical with that of Glc1Man9GlcNAc2-P-P-dolichol. The assay of UDP-Glc:glycoprotein glucosyltransferase allowed detection of the activity in microsomal membranes in which endogenous acceptors appeared to be absent or almost absent, such as those derived from mung bean, Mucor rouxii, Crithidia fasciculata, and Trypanosoma cruzi cells. (ABSTRACT TRUNCATED AT 250 WORDS)
Hierarchical structure analysis of sport videos using HMMS

This paper focuses on the use of hidden Markov models (HMMs) for structure analysis of sport videos. The video structure parsing relies on the analysis of the temporal interleaving of video shots, with respect to a priori information about video content and editing rules. The basic temporal unit is the video shot and visual features are used to characterize its type of view. Our approach is validated in the particular domain of tennis videos. As a result, typical tennis scenes are identified. In addition, each shot is assigned to a level in the hierarchy described in terms of point, game and set.
Smart personal health care monitoring services design using UML

Telecare systems are costly solution to treatment of patients with chronic diseases such as heart disease. The self health care monitoring system aim to be able to monitor the condition of the vital organs in patients continuously at home. The proposed system consists of a data acquisition module that uses a non-invasive wireless sensors, sensor gateway that serves to process data, store medical data to the server and sends a warning message the abnormal condition of the patients to the relevant parties, medical servers using cloud computing that feature electronic health records and web portals, and applications on mobile devices to display data the patient's condition. UML will be used to represent software development system in self-monitoring of health care.
Differential effects of fedotozine compared to other kappa agonists on diuresis in rats.

The aim of our study was to test the effect of fedotozine (0.1-30 mg/kg, s.c.), a novel kappa opioid agonist, on water diuresis in the conscious hydrated rat. Its effect was compared to that of morphine (2.5-10 mg/kg), a mu opioid agonist and to some of the recognized kappa agonists described in the literature: bremazocine (0.3-30 micrograms/kg), tifluadom (0.1-3 mg/kg), Cl 977 1-1000 micrograms/kg), (-)-cyclazocine (0.01-1 mg/kg), PD 117,302 (0.03-3 mg/kg), U-50,488h (0.25-10 mg/kg) and U-69,593 (0.3-3 mg/kg). The effect of fedotozine was also tested after intracerebroventricular administration (100 micrograms/kg) and compared to that of U-50,488h (10-30 micrograms) and dynorphins A(1-17), A(1-13) and B(1-13) (2.5-10 micrograms). All the reference kappa agonists administered by the s.c. route induced water diuresis, whereas morphine inhibited diuresis and electrolyte excretion. However, fedotozine (0.1-30 mg/kg s.c.) had no effect on diuresis, even after low doses of naloxone (0.1 mg/kg s.c.) or nor-BNI (10 mg/kg s.c.), and at 1 mg/kg had inconsistent effects on electrolyte elimination. When administered in the lateral ventricle of the brain, U-50,488h and dynorphin A(1-17) induced water diuresis, unlike fedotozine (100 micrograms), DYN A(1-13) and DYN B(1-13) that had no effect on urine output. Furthermore, fedotozine did not alter the diuretic effects of U-50,488h. These results suggest that fedotozine is an atypical kappa agonist, lacking activity on the kappa receptor subtypes regulating diuresis.
Measured Sediment Yield Rates From Semiarid Rangeland Watersheds

Abstract Data describing long-term sediment yield rates on semiarid rangeland watersheds are relatively rare. To augment existing data and gain a better understanding of the controlling variables, sediment yields from 8 subwatersheds within the US Department of Agriculture–Agricultural Research Service Walnut Gulch Experimental Watershed in southeastern Arizona were computed from stock pond sediment accumulation measurements, water level records, and estimates of sediment transported in pond overflows. Sediment accumulation records ranging from 30 to 47 years were evaluated for subwatersheds ranging in size from 35.2 to 159.5 ha. Sediment yield ranged from 0.5 to 3.0 m3·ha−1·y−1, with a mean of 1.4 m3·ha−1·y−1 and a standard deviation of 1.0 m3·ha−1·y−1. As expected, runoff volume was a significant factor (P = 0.005) in explaining the variability in sediment yield, but regression analysis demonstrated other variables are important. For example, the ratio of watershed area to main channel length significantly described (P = 0.06) sediment yield, suggesting that more detailed measurements are needed to characterize channel networks to relate internal watershed sediment transport and deposition processes to sediment delivery at the outlets. To generalize sediment yield rates across rangeland regions, additional research is necessary to determine the relative influence of rainfall and runoff patterns, and watershed physiographic and geomorphic characteristics on sediment transport.
Growth of seventy‐eight recurrent mammary cancers: Quantitative study

With the model of exponential growth of cancers, it is possible to calculate the doubling time (DT) of a tumor from the recurrent nodule in the operation site. It is reasonable to suppose that the recurrence has its origin in a contemporaneous uni‐ or paucicellular hematogenic metastasis of the reparative granuloma. The average DT value of 78 cutaneous recurrences of operated mammary cancers is 40 days, with extremes of 3 to 211 days. The distribution of the DT values is bimodal, corresponding to two varieties of mammary cancer, one of quick growth with a DT of 25 days, the other of slow growth with an average DT of 93 days. In the rapid‐growth group encephaloid cancers have a lower DT than scirrhous cancers.
Expression profiling of the developing testis in wild‐type and Dazl knockout mice

Genetic understanding of male‐factor infertility requires knowledge of gene expression patterns associated with normal germ cell differentiation. The mouse is one of the best models of mammalian fertility due to its well‐characterized genetics and the existence of many infertile mutants both naturally occurring and experimentally induced. We used cDNA microarrays firstly to investigate normal gene expression in the wild‐type (wt) testis and secondly to gain a better insight into the effect of the disruption of the Dazl gene on spermatogenesis. We constructed a cDNA microarray from a subtracted and normalized adult testis library and focused on six developmental time‐points during the initial synchronous wave of spermatogenesis. The results suggest that in the wild‐type testis, 89.5% of genes on our chip change expression dramatically during the time‐course. To identify patterns in the gene‐expression data, a k‐means clustering algorithm and principal component analysis were used. In the Dazl knockout testes, the majority of genes remain at baseline levels of expression, because absence of Dazl has a severe effect on cell‐types present in the testis. Although in the prepubescent Dazl‐null mice the final point reached in germ cell development is the leptotene‐zygotene stage, the microarray results suggest that lack of Dazl expression has a detectable effect on the mRNA complement of germ cells as early as day 5 when only type A spermatogonia are present. Mol. Reprod. Dev. 67: 26–54, 2004. © 2004 Wiley‐Liss, Inc.
Title: Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia. Running Head: 2HG predicts IDH mutations and clinical outcome in AML

Cancer-associated IDH mutations produce the metabolite 2-hydroxyglutarate (2HG), but the clinical utility of serum 2HG measurements is not established. We studied whether 2HG measurements in AML patients correlate with IDH mutations, and whether diagnostic or remission 2HG measurements predict survival. Serum from 223 adults with de novo AML (62 IDH-mutated, 161 wild-type) were analyzed for 2HG concentration by reverse-phase liquid chromatography-mass spectrometry (LC-MS). Pretreatment 2HG levels ranged from 10 to 30,000ng/ml and were elevated in IDHmutants (median 3004ng/ml), compared to the wild-type cohort (median 61ng/ml) (p<0.0005). 2HG levels did not differ among IDH1 or IDH2 allelic variants. In receiver operating curve (ROC) analysis, a discriminatory level of 700ng/ml segregated patients with and without IDH mutations with 86.9% sensitivity and 90.7% specificity. On repeat mutational analysis of 13 IDH wild-type samples with 2HG levels >700ng/ml, IDH mutations were identified in nine samples. IDH-mutant patients with 2HG levels >200ng/ml at complete remission experienced shorter overall survival compared to those with 2HG<200ng/ml (HR 3.9, p=0.02). We establish a firm association between IDH mutations and elevated serum 2HG concentration in AML. These data confirm that serum measurement of an oncometabolite provides useful diagnostic and prognostic information, and can improve patient selection for IDH-targeted therapies. For personal use only. on August 25, 2017. by guest www.bloodjournal. org From
A method of road condition estimation and feedback utilizing haptic pedal

These days, electric vehicles are developing rapidly. Electric vehicles are expected to be alternative to the conventional gasoline engine vehicles and many researchers have studied motion control of electric vehicle. In this paper, a method how to feedback the road condition to the driver, which utilizes real-time road condition estimation method using sensor information of traction motor, is proposed. Fixed trace (FT) algorithm which is one of real-time identification methods and driving force observer which estimates driving force and friction coefficient are used to estimate road condition. To feedback road condition to the driver, haptic pedal system which uses a motor set in the acceleration pedal is proposed. In haptic pedal motor, disturbance observer and reaction torque observer is implemented to estimate driver input to the acceleration pedal without using force sensor. Simulation is carried out to show the validity of the proposed method.
Characterization of a feminizing testicular leydig cell tumor by hormonal profile, immunocytochemistry, and tissue culture

A patient with gynecomastia and a nonpalpable testicular Leydig cell tumor is presented. Estradiol and progesterone levels were elevated whereas serum testosterone was reduced. Following removal of the tumor the hormonal values returned to normal with reduction of gynecomastia. Tumor tissue was maintained in culture for 9 days during which high estradiol levels as well as lesser quantities of testosterone and progesterone were demonstrated in the culture medium. Elevation of progesterone supports a block of 17 alpha‐hydroxylase activity caused by increased endogenous estradiol. This is the first case of a cultured feminizing testicular Leydig cell tumor in which hormone production was demonstrated. The freshly removed tumor as well as the cultured tissue material were studied by immunocytochemical methods and biochemical analysis of cytoskeletal proteins. These methods revealed vimentin as the exclusive type intermediate sized filament in both. This is the first demonstration of vimentin in a Leydig cell tumor, in agreement with its occurrence in normal Leydig cells. Cancer 56: 1667‐1676, 1985.
Analysis of practical LDPC decoders in tanner graphs with absorbing sets

Absorbing sets (ASs) cause the error floor phenomenon in many Low-Density Parity-Check (LDPC) codes. A recent, simplified system model for Min-Sum (MS) LDPC decoding [1] predicts that ASs exhibit a threshold behavior: if all variable nodes in an AS have channel messages above the threshold, the AS cannot trap the decoder. The threshold is a real-valued parameter that depends on the topology of the AS, and can be evaluated by a nonlinear optimization. In this paper we describe a simple, fast algorithm for evaluating the AS threshold. Additionally, we show that the algorithm is valid also for scaled-MS decoding. We show with an example that the threshold values under scaled-MS decoding are smaller than under MS decoding. Accordingly, scaling decreases the error floor.
Performance improvement of visual-inertial navigation system by using polarized light compass

Purpose This paper aims to present a method for improving the performance of the visual-inertial navigation system (VINS) by using a bio-inspired polarized light compass. Design/methodology/approach The measurement model of each sensor module is derived, and a robust stochastic cloning extended Kalman filter (RSC-EKF) is implemented for data fusion. This fusion framework can not only handle multiple relative and absolute measurements, but can also deal with outliers, sensor outages of each measurement module. Findings The paper tests the approach on data sets acquired by a land vehicle moving in different environments and compares its performance against other methods. The results demonstrate the effectiveness of the proposed method for reducing the error growth of the VINS in the long run. Originality/value The main contribution of this paper lies in the design/implementation of the RSC-EKF for incorporating the homemade polarized light compass into visual-inertial navigation pipeline. The real-world tests in different environments demonstrate the effectiveness and feasibility of the proposed approach.
Inhibitory effects of talipexole and pramipexole on MPTP-induced dopamine reduction in the striatum of C57BL/6N mice.

We have investigated the effects of two novel antiparkinsonian drugs, talipexole (Domin) and pramipexole, on MPTP-induced dopamine (DA) reduction in the striatum of C57BL/6N mice in comparison with those of bromocriptine. Fifteen days after MPTP treatment (25 mg/kg, i.p., given daily for 5 days), the DA content in the striatum was decreased to 40-60% of the control value. Among the three dopamine receptor agonists, talipexole and pramipexole (1 mg/kg, i.p., once a day for 20 days) more significantly suppressed the MPTP-induced DA reduction in the striatum than bromocriptine (10 mg/kg, i.p., once a day for 20 days). Talipexole did not influence [3H]MPP+ uptake into striatal synaptosomes. These results suggest that talipexole and pramipexole have a protective effect against MPTP-induced DA reduction in the striatum of C57BL/6N mice.