Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimental Pharmacodynamic and Kinetic Studies Related to New Combination Therapies against Falciparum Malaria

5 LIST OF PUBLICATIONS 6 LIST OF ABBREVIATIONS 9 INTRODUCTION 10 EPIDEMIOLOGY OF MALARIA 10 THE MALARIA PARASITE 10 Life cycle of P. falciparum 11 CHEMOTHERAPY OF MALARIA 12 Drug resistance in P. falciparum malaria 12 ARTEMISININ AND ITS DERIVATIVES 14 The plant Artemisia annua 14 Chemical structure and metabolism 15 Antimalarial activity 15 Mechanism of action 16 Adverse effects 17 Pharmacokinetics 18 Analytical methods 18 SPECIAL BACKGROUND 20 PAPER I: TIME DEPENDENT PHARMACOKINETICS OF ARTEMISININ 20 PAPER II AND III: COMBINATION THERAPY 21 Chloroquine 25 Amodiaquine 25 Pyronaridine 26 Atovaquone 27 Mefloquine (Lariam®) 27 Quinine 28 PAPER IV: IN VITRO PHARMACODYNAMICS OF MALARONE® 29 Malarone® 29 Proguanil 29 Cycloguanil 30 AIMS OF THE STUDY 31 MATERIALS AND METHODS 32 AUTO-INDUCTION OF ARTEMISININ IN THE RATS 32
Spaces of urbanity. From the village square to the boulevard

Urbanism is much more than simply an agglomeration of houses : it is a particular way of living space. Our considerations starts out from some of the historically prominent figures of urbanity, such as the market-place, the boulevard and the coffee house. Semiotics of space may either involve a certain number of elementary building-blocks being combined in particular ways, much as language is ; or it may be interested in the way a place is defined by the activities taking place in it. Opting here for the second approach, we try to give it a more secure grounding by incorporating into it a division of geography, know as time geography, which is involved with trajectories in space and time. We add to this a qualitative dimension which is properly semiotic, and which derives from the notion of border, itself a result of the primary semiotic operation of segmentation. We can learn a lot about semiotical properties of borders also from the social psychologies of Janet and Simmel, the proxemics of Hall, and the semiotics of Hammad. Such considerations permit us to define certain peculiar semio-spatial objects as, notably, the boulevard, considered as an intermediate level of public space, located between the village square and the coffee house presiding other what Habermas called the public sphere. Adding to the process of privatisation adduced by Hammad the additional process of publication, which is not simply the reversal of the former, we attempt to characterise the peculiar potentialities of urban space. Urbanity will emerge as a scene on which the gaze, well before the word, mediates between the sexes, the classes, the cultures, and other avatars of otherness. (Less)
Spatial Competition in Quality

We develop a model of vertical innovation in which firms incur a market entry cost and position themselves in the quality space. Once established, firms compete monopolistically, selling to consumers with heterogeneous tastes for quality. We establish existence and uniqueness of the pricing game in such vertically differentiated markets with a potentially large number of active firms. Turning to firms' entry decisions, exogenously growing productivities induce firms to enter the market sequentially at the top end of the quality spectrum. We spell out the conditions under which the entry problem is replicated over time so that each new entrant improves incumbent qualities in fixed proportions. Sequential market entry overcomes the asymmetry of the location problem, which unavoidably arises in the quality spectrum because of its top and bottom ends. Our main technical contribution lies in handling this asymmetry, a feature absent in Salop (1979) and other circular representations of Hotelling (1929) and Lancaster (1966).
Placed: Assessing the developmental progression of remedial math students at a large Midwestern community college using ALEKS

The focus of this study was to investigate the developmental climb of students at one large Midwestern community college based on their Assessment and Learning in Knowledge Spaces (ALEKS) placement scores in remedial mathematics. Specifically, the purpose of this research study was to assess and explore the predictors of student progression and their progression rates in remedial math at this college. Remediation is important because of the nature of the community college with its open access that attracts underprepared students. Further, community colleges are growing in popularity and are often used as a stepping stone for students who may be underprepared to enter four-year institutions. The conceptual framework used for this investigation of remedial students at one community college was the Developmental Climb of Hagedorn, Lester, and Cypres (2010), who focused on the nature of remedial/developmental courses and the difficulty of progression through the sequence to college-level math. This study examined 2,172 students’ transcript data and demographic information from a secondary data source at one Midwestern community college. The data set was followed for four consecutive terms starting in Fall 2015 and ending in Fall 2016. Using quantitative research analysis, including descriptive analysis and logistic regression, the researcher hypothesized which factors contributed to the students’ remedial math progression to college-level math. The results indicated that there is a slight demographic difference in this community college sample compared to community college students nationally. This
Prevalence of Musculoskeletal Disorders in Workers In An Industry in Ahmednagar District, Maharashtra.

Introduction: Musculoskeletal disorders are a major public health problem in industrialized and developing countries. The present study was aimed to find out the prevalence of acute and chronic WMSD’s in Industrial workers. Methodology: This cross-sectional observational study was carried out in 60 workers of the Adon Block department workers of the electrical & automation industry, Ahmednagar. Pre-structured occupational Performa was filled by asking questions in the worker’s local language. The Nordic pain Questionnaire was filled by asking the subjects to mark the sites of pain on body chart paper. The risk factors for work-related musculoskeletal problems were assessed by the working posture of workers and repetitive movements in industrial set up. The data collected were interpreted and analyzed. Results: In the present study, 60 workers were selected, of which a number of females were 39 (65%) while males were 21 (35%). The Neck (20.2%) followed by the shoulder (14.9%), elbow (14.4%) and knee (14.4%) were most commonly involved. There was a statistically significant variation in the number of workers involved according to the posture (sitting vs standing) and part of the MSK system involved. Conclusion: The WMSD’s are common in Adon block department workers. The involvement of neck, shoulder, lower back and arm was common in sitting position, while the involvement of upper back, elbow and knee were common in standing position. The disorders are commonly seen in workers irrespective of their duration of work and gender. Keywords: Musculoskeletal disorders; Industry Workers; Nordic pain Questionnaire; Ahmednagar.
COARSE-GRAINING AND THERMODYNAMICS IN FAR-FROM-EQUILIBRIUM SYSTEMS

Lying at the core of statistical physics is the need to reduce the number of degrees of freedom in a system. Coarse-graining is a frequently-used procedure to bridge molecular modeling with experiments. In equilibrium systems, this task can be readily performed; however in systems outside equilibrium, a possible lack of equilibration of the eliminated degrees of freedom may lead to incomplete or even misleading descriptions. Here, we present some examples showing how an improper coarse-graining procedure may result in linear approaches to nonlinear processes, miscalculations of activation rates and violations of the fluctuation-dissipation theorem.
Testing for Mispricing of Stocks on the Ghana Stock Exchange: A Case of Selected Banking Stocks

This paper is aimed at investigating mispricing of stocks on the Ghana stock exchange. Four stocks mainly the banking stocks were sampled for the purpose of this study. Mispricing of stocks in this paper is measured as the difference between the current dividend-price ratio and rationally estimated fundamental value of stock using Campbell and Shiller (1988) model. A monthly mispricing is estimated for the period 2000 to 2015 and the results of the test for mispricing on the selected stocks show that their prices significantly deviate from their fundamental value. Keywords: Rationality, Market pricing, Imperfect market, Fundamental value, Stock prices, Mispricing
Cognitive Factors in Consultee Defensiveness.

ABSTRACT Defensiveness is the most frequently utilized concept to explain iradeguate change on the part of consultees. Defensiveness, in this context, indicates a motive to protect a central component of the self-concept, or a motive to present oneself favorablyAnother source of consultee resis-. ance to change results from the limitations of the human cognitive apparatus. Some of these limitations include: (1) the lack of a conscious awareness of higher mental processes: (2) disproportional cognitive 7.vailability of vivid events; (3) fundamental attribution error: and (4) other memory-related factors. While the defensiveness hypothesis assigns blame to the consultee for consultation failure, cognitive explanations do not, and tend to lead to changes in consultant behavior designed to circumvent these limitations. (Author/NRB)
LOW TEMPERATURE PROPERTIES OF PIEZOELECTRIC ACTUATORS USED IN SRF CAVITIES COLD TUNING SYSTEMS

High accelerating gradients (10MV/m for SNS, 33MV/m for ILC) at which SRF cavities will be operated in pulsed machines induce frequency shift much higher than the resonator bandwidth. This so-called Lorentz detuning should be compensated dynamically by means of an active piezo-tuning system. In the frame of the CARE project activities supported by EU, IPN Orsay participates to the development of a fast cold tuning system based on piezoelectric technology for SRF cavities operating at temperature T=2K. The aim of this study is the full characterization of piezoelectric actuators at low temperature including dielectric properties (capacitance, impedance, dielectric losses), radiation hardness tests (tolerance to fast neutrons), mechanical measurements (maximum displacement, maximum stroke) and thermal properties (heating, heat capacity). Results obtained in the temperature range from 2K up to 300K will be presented and discussed.
UvA-DARE ( Digital Academic Repository ) Signaling in vascular biology : The role of GTPases and GEFs in endothelial cell function

Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva. nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.
Synthesis and antibacterial property studies of the N'-(4- substituted) isonicotinohydrazides and their copper (II) complexes

A series of Schiff base ligands ( L 1 -L 4 ) prepared by condensation of isonicotinic acid hydrazide with substituted benzaldehydes and their corresponding copper(II) complexes ( L 1 A-L 4 A ) had been synthesized and characterized based on IR, 1 H NMR and electronic absorption spectroscopy as well as by molar conductivity and elemental analyses. The in-vitro antimicrobial activity of the compounds against Staphylococcus aureus , Enterococcus feacalis , Escherichia coli and Pseudomonas aeruginosa studied using agar ditch method indicated that the copper complexes exhibited higher activity than the corresponding ligands. The antimicrobial activity of both the ligands and complexes was dependent on the electronic effect of the halogen substituent, which decreased in the order F > Cl > Br. Keywords: N -(4-substitutedbenzylidene) isonicotinohydrazide, Halogen Schiff Bases, Copper (II) Complexes, Antimicrobial Activity
COMPOSIÇÃO ETÁRIA DOMICILIAR E O ACESSO AO TRABALHO DAS MULHERES ADULTAS – BRASIL 2000 E 2010

Resumo: Este estudo tem como objetivo principal investigar a associação entre condições de acesso ao trabalho das mulheres adultas brasileiras e a presença de criança e de idoso nos domicílios, comparando com a população masculina. A intenção é abordar as condições de inserção das mulheres no mercado de trabalho a partir de uma perspectiva multidimensional. O nível de acesso ao trabalho é captado através de um índice sintético composto por indicadores relacionados a três dimensões – disponibilidade de trabalho, qualidade da ocupação e remuneração auferida no trabalho. Entende-se que tanto o fato de estar ocupada, quanto a qualidade da ocupação e o nível de remuneração são aspectos importantes e que devem ser investigados em conjunto. Utilizando os dados dos censos de 2000 e 2010, foram estimadas regressões para testar
Impacts of road access on lake trout (Salvelinus namaycush) populations: regional scale effects of overexploitation and the introduction of smallmouth bass (Micropterus dolomieu)

In lake trout (Salvelinus namaycush) lakes of northeastern Ontario, Canada, aerial surveys of fishing activity on individual lakes (N = 589) and quantitative gillnet surveys (N = 65) were used to assess the effects of road access on angling effort and the presence of introduced smallmouth bass (Micropterus dolomieu). Angling effort, particularly during the open-water season, was highest and often exceeded estimated sustainable levels on lakes with good road access. Approximately 25% of the remote lakes also received excessive pressure during the winter season. Angler numerical responses to lake trout abundance were detected in remote lakes, but not in road-accessible lakes. Smallmouth bass were more prevalent in lakes with road access and human settlement (either cottages or lodges), supporting the theory that they were introduced into these lakes. Lake trout populations were depleted throughout much of the study range. Even without road access or smallmouth bass, lake trout abundance was still 47% lower .
Release of ammonium and urea from dissolved organic nitrogen in aquatic ecosystems

The potential for release of ammonium (NH,+) a n d o r urea from the pool of dissolved organic nitrogen (DON) was examined in san~ples taken from Lake l n n e r e t (Israel), the k v e r Charente estuary and coastal water near Ile de Re (French Atlantic coast). After prefiltration through 1.0 or 1.2 pm membranes to remove most of the microbiota with the exception of bacteria, water samples with or without supplements (40 pM) of various organic nitrogen compounds (arginine, glucosamine, guanine, hypoxanthine, lysine, ornithine or thymine) were incubated at in situ temperatures, in the dark. for 7 to 14 d. Concentrations of NH,' and urea were monitored during the incubation period. Increases of NH,' with time were observed in 8 out of 12 experiments with unsupplemented lake samples, and in a single trial with coastal water, but not with Charente estuary water. In some expenments, increases of urea concentrations were also observed. The addition of organic nitrogen compounds almost always led to NH4+ increases in samples from all locations; guanine, hypoxanthine, arginine and, in the case of Charente water, glucosamine gave rise to urea. The addition of nitrification inhibitors (40 pM) at the start of some experiments gave inconsistent results, but in some cases appeared to increase the concentrations of NH,' with time. Taken together, the results of these experiments clearly indicate the potential in natural waters for degradation of DON pool constituents by indigenous bactena andor free dssolved enzymes to NH,+ or urea; these in turn can be effectively exploited by the ambient microbiota. The breakdown of DON with the concomitant release of readily available compounds such as NH,' or urea could be an important process in the nitrogen nutrition of phytoplankton and bacteria.
Identification of Morpho-physiological Traits Affecting White Sugar Yield in Sugar Beet

This research was carried out to evaluate the effects of some morphophysiological traits on white sugar yield of 10 commercial sugar beet (Beta vulgaris L.) varieties. All experiments were conducted in four important sugar beet growing areas in Iran, i.e. Moghan, Khoy, Karaj and Zarghan in 2006 and 2007. The experiment was arranged as a randomized complete block design with three replications in each environment. Total leaf production and cumulative number of senescent leaves were affected more by location than by genotype. There were significant differences among varieties for white sugar yield. Multiple regression analysis indicated that leaf death rate at the crop development, mid-season and late-season stages; leaf appearance rate and petiole dry weight at the crop development stage; and root dry weight at the late-season stage affected white sugar yield. Leaf death rate had the highest positive effect on white sugar yield at the late-season stage and the highest negative effect at the mid-season stage. In conclusion, leaf death rate at the crop mid-season stage and root dry weight at the late-season stage contributed the most to white sugar yield of sugar beet varieties.
Osteoporosis Education in College-Age Women

Osteoporosis, a degenerative bone disease, is a preventable disease. The purpose of this study was to determine if an educational intervention would increase knowledge and influence women to change their behaviors (i.e., exercise and dietary calcium intake) related to osteoporosis. A random sample of 149 college female students participated in this study. Participants completed two questionnaires consisting of the Osteoporosis Knowledge Test and the Osteoporosis Self-Efficacy Scale. Participants were surveyed to determine their knowledge of osteoporosis and their intent to change their health behavior before and after an educational intervention. Statistical analysis indicated that an educational intervention increased the subjects’ knowledge about osteoporosis and elicited self-reported confidence level in health lifestyle behavioral changes. These findings suggest that an educational intervention is one strategy that can be implemented to bring about awareness of those at risk for osteoporosis and behavioral changes they can incorporate into their lives.
The development of co-curricular interventions to strengthen female engineering students' sense of self-efficacy and to improve the retention of women in traditionally male-dominated disciplines and careers

Self-efficacy relates to positive outcomes for women studying and working in traditionally male-dominated fields such as engineering, science, and technology. Many women engineering students (WES) experience fear and insecurity about how they will be treated and perceived in this traditionally male-dominated field, either as a WES or as a working engineer. This study provides support for the development of co-curricular interventions to improve the self-efficacy of WES at a South African tertiary institution. The research design for this study is based on a phenomenological approach that uses a process of critical analysis of evaluation and feedback documents relating to the various co-curricular interventions and their perceived influence on selected WES’s self-efficacy. Finally, as there has been no other South African research on WES and the sources of self-efficacy, this research is unique in the South African context.
MIPAS observations of longitudinal oscillations in the mesosphere and the lower thermosphere: climatology of odd-parity daily frequency modes

Abstract. MIPAS global Sun-synchronous observations are almost fixed in local time. Subtraction of the descending and ascending node measurements at each longitude only includes the longitudinal oscillations with odd daily frequencies nodd from the Sun's perspective at 10:00. Contributions from the background atmosphere, daily-invariant zonal oscillations and tidal modes with even-parity daily frequencies vanish. We have determined longitudinal oscillations in MIPAS temperature with nodd and wavenumber k = 0–4 from the stratosphere to 150 km from April 2007 to March 2012. To our knowledge, this is the first time zonal oscillations in temperature have been derived pole to pole in this altitude range from a single instrument. The major findings are the detection of (1) migrating tides at northern and southern high latitudes; (2) significant k = 1 activity at extratropical and high latitudes, particularly in the Southern Hemisphere; (3) k = 3 and k = 4 eastward-propagating waves that penetrate the lower thermosphere with a significantly larger vertical wavelength than in the mesosphere; and (4) a migrating tide quasi-biennial oscillation in the stratosphere, mesosphere and lower thermosphere. MIPAS global measurements of longitudinal oscillations are useful for testing tide modeling in the mesosphere and lower thermosphere region and as a lower boundary for models extending higher up in the atmosphere.
The Role of Ethics in Corporate Governance (Peranan Etika dalam Tadbir Urus Korporat)

The purpose of this paper is to explore the role of ethics in corporate governance. The research is situated within an interpretive approach. The interview technique was employed to explore the issue. Interviews were conducted with 13 experts who were involved in the reform of Malaysian corporate governance. The experts were selected based on their expertise and experience. Three themes emerged in respect of the main role of ethics in corporate governance: corporate governance is a code of ethics, corporate governance is inclusive of ethics, and ethics is an affiliate of corporate governance. The research has contributed in enhancing the understanding of corporate governance by shifting the focus from a structural perspective to a moral perspective and manages to highlight the contradictions that lie within the understanding of corporate governance in moral perspective. ABSTRAK Tujuan kajian ini adalah meneroka peranan etika dalam tadbir urus korporat. Kajian ini menggunakan pendekatan interpretasi. Temubual sebagai teknik untuk menyelidik isu kajian. Seramai 13 pakar yang terlibat dalam reformasi tadbir urus korporat di Malaysia telah ditemubual. Pakar-pakar tersebut telah dipilih berdasarkan kepakaran dan pengalaman. Dapatan kajian menunjukkan tiga tema muncul berkenaan peranan utama etika dalam tadbir urus korporat: tadbir urus korporat adalah kod etika, etika adalah sebahagian dari tadbir urus korporat dan etika adalah berganding dengan tadbir urus korporat. Kajian ini menyumbang kepada pemahaman tadbir urus korporat iaitu dengan mengalihkan fokus dari struktur kepada perspektif moral. Kajian ini berjaya menyangkal pemahaman tadbir urus korporat dari perspektif moral. Keywords: Ethics; Corporate governance; Code of ethics; Inclusivity; Affiliations
Line shape of beam deflection of magnetic nanoparticles in a Stern-Gerlach setup

An adaptation of the famous Stern-Gerlach experiment has found important applications to nanomagnetism. A beam of magnetic clusters is sent in a projectile through an inhomogeneous magnetic field and the resultant deflected spots are collected on a detector screen. The difference with the historic experiment is that the beam deflection during the traversal through the magnetic region is influenced by rotational diffusion of the magnetization vector across an anisotropy barrier. In this paper we provide a complete analysis of the line profile of the deflected spots and a detailed comparison with experimental data.