Miracle-dz/UniFAR-FTUs huggingface dataset:
Determination of Arsenic Concentration in Ground Water and its Effects on Children: A Case Study of Sonarpur and Baruipur Block, South 24 Parganas, West Bengal

Arsenic contamination in groundwater has been termed as ‘the largest mass poisoning in history’ because of its detrimental effects on human population (Mori et al 2018). The Bengal Delta Plain (BDP) is the most arsenic contaminated region among the whole world where millions of people use arsenic contaminated water for drinking purposes (Bhattacharya et al, 2002). Children are more susceptible to arsenic than adult. Consumption of high arsenic contaminated water from the very first stage of life can develop arsenic related skin problems in early life. The effects of arsenic induced health diseases have multidimensional influences on the society. Apart from physical manifestation, socio economic impacts have been confronted by the sufferer such as economic instability due to loss of work, social disgrace, suicidal tendency and many other causes are related to these (Das and Roy, 2013). GIS platform was used for the study to prepare a hazard map considering the arsenic concentration of the village level drinking water sources and the geographical location as input. Baruipur and Sonarpur block of South 24 Parganas district, West Bengal, was considered for the study.
Factors That Account For Occupancy Rates in Hostels: A Case of Students Hostels Hosting Makerere University Business School Students

i DECLARATION . iii APPROVAL . ivii ACKNOWLEDGEMENT . iv TABLE OF CONTENTS . Error! Bookmark not defined. CHAPTER ONE . 1 FACTORS THAT ACCOUNT FOR LOW OCCUPANCY RATES IN HOSTELS . 1 1.0 Introduction . 1 1.1 Background . 1 1.2 Statement of the Problem . 4 1.3 Purpose of the study . 4 1.4 Research questions . 5 1.5 The scope of the study . 5 1.6 Justification of the study . 5 1.7 Significance of the study . 5 1.8 Theoretical Framework . 6 CHAPTER TWO . 7 LITERATURE REVIEW . 7 2.
Regulated release of P-Tefb from the 7sk Snrnp

Regulation of transcription elongation by P-TEFb is critical for proper gene expression and cell survival. The cell possesses large quantities of P-TEFb, but the vast majority of it is inactive in the 7SK snRNP. The 7SK snRNP is composed of the small nuclear RNA 7SK, an inhibitory protein HEXIM which mediates the interaction between P-TEFb and 7SK, the Methyl Phosphate Capping Enzyme, and the 7SK stability protein LARP7. Since the discovery of the 7SK snRNP, research has been conducted to determine how P-TEFb is released from this complex. The goal of the research presented in this thesis is to better understand how the 7SK snRNP regulates P-TEFb and ultimately, gene expression. This work documents the discovery and characterization of the 7SK stability protein LARP7. LARP7 is is associated with 7SK regardless of the presence of P-TEFb and HEXIM1. Stabilization of 7SK is essential for maintenance of the RNP because loss of LARP7 results in an increase in free P-TEFb and a significant reduction in the amount of 7SK. These results indicate that stabilization of the 7SK snRNP by LARP7 is important for regulating P-TEFb homeostasis. Although P-TEFb was first characterized from Drosophila lysates, the conservation of the 7SK snRNP and the mechanisms regulating P-TEFb inhibition have not been described. Here, the Drosophila melanogaster homologues of LARP7 and 7SK are characterized. These studies show that the system of P-TEFb regulation is similar in flies and this makes Drosophila an attractive model system for studying P-TEFb regulation through embryonic and larval development. Finally, factors and modifications involved in releasing P-TEFb directly are explored. An assay was developed for discovering proteins that can bind to and release P-TEFb from the 7SK snRNP. Use of this assay showed phosphorylation, dephosphorylation, and acetylation of the components of the 7SK snRNP do not cause P-
Grape-based brandies: production, sensory properties and sensory evaluation

Abstract: This chapter focuses on the sensory properties and volatile composition of grape-based brandies and the most important considerations for sensory evaluation of such products. The first part of the chapter provides a definition for brandy and a description of the production process and some important brandy styles. The main part of the chapter discusses typical brandy aromas, their origin in the production process and the associated flavour compounds. The final part of the chapter provides some practical considerations for the sensory evaluation and consumer testing of brandy and is concluded with some possible future trends in the sensory research of brandy.
Clerodendrum inerme (L.) Gaertn. Extract Exerts Anticancer Activity on Lung Cancer Cells

Cancer is the leading cause of death word wide. Recently there are no new drugs for safe and efficient treatment. Clerodendrum inerme (L.) Gaertn. (Verbenaceae) plant is being used by the ethnic people for cancer treatment. In this study, cytotoxic and antiproliferative potential of hydroalcoholic (methanol and water; 70:30 v/v) extract of C. inerme were evaluated. Various anticancer investigations performed like, lung cancer cell A-549 culture, dye exclusion assay, MTT assay, morphological changes and compatibility with RBC, confirmed the presence of the moiety that have the cytotoxic and antiproliferative potential. Compatibility with RBC was observed, when treated with standard drug doxorubicin, and hydroalcoholic extract of C. inerme at 259.5 μg/ml concentration (IC50). In addition, the same treatment reveled, decrease in cytotoxic efficacy and cell viability against lung cancer cells. Furthermore, change in the cell morphology also suggesting potent antitumor properties of C. inerme. Dhaka Univ. J. Pharm. Sci. 17(2): 191-196, 2018 (December)
Efectos de la suplementación con vitamina E en la reducción del dolor muscular de inicio retardado. Una revisión narrativa.

Antecedentes: actualmente existe un creciente interés en investigar métodos que logren disminuir el dolor muscular de inicio retardado. Se ha postulado que antioxidantes como las vitaminas C y E pueden atenuarlo. Objetivo: evaluar la efectividad de vitamina E en la atenuación del dolor muscular de inicio retardado. Materiales y métodos: se realizó una búsqueda bibliográfica en las bases de datos Medline, Registro Central Cochrane, Scopus, SportDiscus y SciELO, utilizando los términos: “vitamin e supplementation”, “muscle damage” y “delayed onset muscle soreness”. Resultados: se revisaron estudios en diversos grupos poblacionales, con diferentes métodos de evaluación y diversas dosis de vitamina E. Los resultados obtenidos fueron controversiales, en algunos casos se demostró un efecto atenuante del dolor muscular de inicio retardado y en otros casos no. Conclusiones: la vitamina E produce una disminución del estrés oxidativo y estabilización el sarcolema; no obstante, faltan pruebas concluyentes para afirmar que la vitamina E tenga el efecto de generar mejoras en los biomarcadores asociados al dolor muscular de inicio retardado.
Computational fluid dynamics analyses of lateral heat conduction, coolant azimuthal mixing and heat transfer predictions in a BR2 fuel assembly geometry.

To support the analyses related to the conversion of the BR2 core from highly-enriched (HEU) to low-enriched (LEU) fuel, the thermal-hydraulics codes PLTEMP and RELAP-3D are used to evaluate the safety margins during steady-state operation (PLTEMP), as well as after a loss-of-flow, loss-of-pressure, or a loss of coolant event (RELAP). In the 1-D PLTEMP and RELAP simulations, conduction in the azimuthal and axial directions is not accounted. The very good thermal conductivity of the cladding and the fuel meat and significant temperature gradients in the lateral directions (axial and azimuthal directions) could lead to a heat flux distribution that is significantly different than the power distribution. To evaluate the significance of the lateral heat conduction, 3-D computational fluid dynamics (CFD) simulations, using the CFD code STAR-CD, were performed. Safety margin calculations are typically performed for a hot stripe, i.e., an azimuthal region of the fuel plates/coolant channel containing the power peak. In a RELAP model, for example, a channel between two plates could be divided into a number of RELAP channels (stripes) in the azimuthal direction. In a PLTEMP model, the effect of azimuthal power peaking could be taken into account by using engineering factors. However, if the thermal mixingmore » in the azimuthal direction of a coolant channel is significant, a stripping approach could be overly conservative by not taking into account this mixing. STAR-CD simulations were also performed to study the thermal mixing in the coolant. Section II of this document presents the results of the analyses of the lateral heat conduction and azimuthal thermal mixing in a coolant channel. Finally, PLTEMP and RELAP simulations rely on the use of correlations to determine heat transfer coefficients. Previous analyses showed that the Dittus-Boelter correlation gives significantly more conservative (lower) predictions than the correlations of Sieder-Tate and Petukhov. STAR-CD 3-D simulations were performed to compare heat transfer predictions from CFD and the correlations. Section III of this document presents the results of this analysis. « less
Evaluation of the In Vitro Antimicrobial Activity of Ethanolic Extracts Derived from Leaves Of Camellia Japonica Cultivars (Theaceae) Against Enterobacter Cloacae Strain

The increasing incidence of antibiotic resistance among bacterial and fungal pathogens necessitates plants as an alternative therapy in restricting the resistant infectious organisms. The present study was undertaken to determine the antibacterial activity of ethanolic extracts derived from the leaves of Camellia japonica cultivars. The aim of the presented study was to assess the in vitro antimicrobial activity of ethanolic extracts derived from the leaves of C. japonica ‘Kramer’s Supreme‘, ‘C.M. Wilson‘, ‘La Pace‘, ‘Mrs. Lyman Clarke‘, ‘Benikarako’, ‘Fanny Bolis’ against clinical cefuroxime-resistant Enterobacter cloacae strain. Ethanolic extracts were prepared by freshly crushed leaves and evaluated for their antimicrobial activity against Enterobacter cloacae strain locally isolated using disc diffusion assay. Among the six plant extracts screened, C. japonica ‘Mrs. Lyman Clarke‘ exhibited the highest inhibitory zones against the tested strain (the mean value of the zone of inhibition was 12.5 ±0.7 mm). The least activity is attributed to C. japonica ‘La Pace‘ extract. Based on our current investigations it can be concluded that C. japonica and its cultivars possess a mild antibacterial efficacy. This mild activity on the E. cloacae, Gram-negative organisms, is most likely due to the protective nature of the outer membrane of their cell walls. It may also be assumed that the antimicrobial potential of various samples of these plants might be due to a wide variety of compounds present in these plants. The findings reported herein give scientific credence to the traditional uses of these plants and suggest that extracts derived from the leaves of C. japonica and its cultivars merit further phytochemical study as natural antibiotics to identify the secondary metabolites.
Development of astrochemical models based on laboratory data

The more we discover about the molecular composition of the interstellar medium (ISM) the more we realise how difficult it is to reproduce the mechanisms behind this complex chemistry. To date, over 175 different molecular species have been detected in the ISM. Many of them are formed in the gas phase, but there is a growing number of species that form more efficiently on grain surfaces during the collapse of star-forming cores. An important issue in mimicking the interstellar medium chemistry is that there are few observational clues about the synthesis of complex organic molecules on grains; experimental work coupled with chemical modelling is therefore essential in order to understand the chemical complexity of the ISM. UCL_CHEM is a computer model that takes into account the gas-grain interactions occurring during this collapse, with the aim of reproducing the observed abundances of molecules in various astronomical environments. The work in this thesis deals with the coupling of UCL_CHEM with the most recent experimental results on the formation in the solid state of various complex organic molecules including methyl formate (see Chapter 3) and ethylene oxide and acetaldehyde (whose chemistry is extensively discussed in Chapters 4 and 5), all which have been the subject of recent astronomical interest. Moreover, important revisions of some reactions occurring in the gas phase have also been made. Despite everything seeming straightforward concerning the interstellar chemistry in the gas phase, there is still a great deal to unearth in this regard. Oxygen, for instance, is an important player in the ISM because it is the most abundant element after hydrogen and helium. Although its chemistry seems well understood, we propose a revised scheme for its reactions with small unsaturated hydrocarbons (see Chapter 6) and we show how the new reaction network affects the molecular abundances of these linear carbon chains. In Chapter 6, we also emphasise the relevance in treating structural isomers as two different species when they show peculiar chemical behaviours. Another key issue in reproducing the interstellar molecular variety concerns the freezeout of species onto dust grain surfaces. In particular, we know little about the constituents of the icy mantles. In Chapter 7, we analyse the case of sulfur-bearing species because the most dominant ice component is still debated.
Investigation of candidate genes for metabolic disorders expressed in liver and pituitary gland by comparing the RNA-seq data of Polish-HF and Polish-Red cattle

Background: Metabolic disorder is a major health problem in dairy cattle, particularly to high milk producing dairy cattle. It is worthily emphasized that metabolic diseases have a very complex etiology and pathogenesis, and the impact of these diseases on hepatic and pituitary gland gene expression and organism oxidative balance is not fully described. The presented study was aimed to determine and predict the hepatic and pituitary gland expression of potential candidate genes in context to maintenance of oxidative balance, negative nitrogen balance, as well as ketosis in Polish HF and Polish Red cattle. Methods: Based on the RNA-seq experimental data, we investigated the candidate genes ( SOD1, SOD2, SOD3, GPx2, GPx3, GPx5, GPx6, GPx7, GPx8, BDH1, FN1, ACSL3 , HMGCL, HMGCS2, BDH2, ACSL6 , ACAT2, IDH3B, ACAT1, HMGCS1, ACSL4 , ACSL1 , PC, CPT1A, OXCT1 and ACSL5 respectively) expressions in liver and pituitary gland tissues of Polish HF and Polish Red cattle. The RNA-seq experimental design comprised of young bulls aged between 6 to 12 months were investigated. For each breed, six liver and six pituitary gland tissues were sequenced using Next-seq 500 illumina platform. The RNA-seq expression data were normalized by the reads per kilobase of exon per million reads mapped (RPKM) method. Results: By comparing the RNA-seq data of liver and pituitary gland tissues, the investigated candidate genes were highly expressed in the hepatic tissues than to pituitary gland in investigated cattle breeds. However, by comparing the Polish HF and Polish Red cattle breeds, results revealed a similar trend of gene expression profiling of all investigated candidate genes for both metabolic tissues. In case of hepatic gene expression profiling, the SOD1, FN1, HMGCL, HMGCS2, ACAT2, ACAT1, HMGCS1, ACSL1 and ACSL5 were highly expressed (FPKM values of >40), followed by SOD2, GPX3, IDH3B, PC and BDH2 as moderately expressed (FPKM values: >10 to 40), followed by SOD2, GPX8, IDH3B, ACAT1, ACSL4 and PC as moderately expressed (FPKM values: >10 to <40), and averagely expressed SOD3, GPX3,GPX5, GPX6, GPX7, GPX2, BDH1, BDH2, ACSL3 , ACSL6 , CPT1A, OXCT1, FN1, HMGCL, HMGCS2, ACAT2, ACAT1, HMGCS1, ACSL1 and ACSL5 respectively, in Polish HF and Polish Red breeds. Conclusions: Based on this presented results on hepatic and pituitary gland gene expression, a further research plan is an essential pre-requisite to validate the identified candidate genes. Study indicated the understanding the genetic factors that predispose metabolic disorders in cattle would benefit the dairy industry as a whole by providing producers, breeding services, and veterinarians a tool to forecast a cow’s susceptibility to metabolic disorders.
PENGARUH CORPORATE GOVERNANCE, UKURAN PERUSAHAAN, DAN KUALITAS AUDIT TERHADAP INTEGRITAS LAPORAN KEUANGAN

Penelitian ini bertujuan untuk menguji pengaruh kualitas audit, tata kelola perusahaan, dan ukuran perusahaan terhadap integritas laporan keuangan. 27 sampel yang digunakan pada penilitian ini adalah perusahaan perbankan yang aktif diperdagangkan dan terdaftar di bursa efek Indonesia sebelum tahun 2012 dengan tahun observasi dari tahun 2012 sampai 2015 dan ditentukan dengan metode purposive sampling. Teknik analisis yang digunakan adalah regresi data panel menggunakan aplikasi E-Views 9. Penelitian ini menggunakan model fixed effect dari hasil uji Chow dan uji Hausman. Hasil dari penelitian ini mengindikasikan bahwa secara bersama-sama, kualitas audit, tata kelola perusahaan, dan ukuran perusahaan berpengaruh terhadap integritas laporan keuangan. Namun secara individual, tata kelola perusahaan dan ukuran perusahaan tidak berpengaruh terhadap integritas laporan keuangan. Sedangkan kualitas audit berpengaruh positif terhadap integritas laporan keuangan.
Effects of the Counter Ion Valency on the Colloidal Interaction between Two Cylindrical Particles

In this study, the effects of counter ion valency of the electrolyte on the colloidal repulsion between two parallel cylindrical particles were investigated. Electrostatic interactions of the cylindrical particles were calculated with the variation of counter ion valency. To calculate the electrical repulsive energy working between these two cylindrical particles, Derjaguin approximation was applied. The electrostatic potential profiles were obtained numerically by solving nonlinear Poission-Boltzmann (P-B) equation and calculating middle point potential and repulsive energy working between interacting surfaces. The electrical potential and repulsive energy were influenced by counter ion valency, Debye length, and surface potential. The potential profile and middle point potential decayed with the counter ion valency due to the promoted shielding of electrical charge. On the while, the repulsive energy increased with the counter ion valency at a short separation distance. These behaviors of electrostatic interaction agreed with previous results on planar or spherical surfaces.
Etude experimentale et theorique du laser a fibre dopee neodyme : synthese des proprietes vectorielles et longitudinales

Ce travail est consacre a l'elaboration d'un modele synthetique pour le laser a fibre dopee neodyme qui prend en compte les variations longitudinales des variables dynamiques, la polarisation du champ laser et le caractere multimode du spectre d'emission. Notre etude fait par ailleurs le lien entre deux modeles couramment utilises pour decrire les proprietes de polarisation de tels lasers. Nous proposons une solution analytique approchee du modele a l'etat stationnaire et etudions theoriquement l'influence de parametres, tels que la longueur de cavite ainsi que les differentes anisotropies qui caracterisent le milieu, sur le comportement en polarisation du laser. La partie experimentale concerne la mesure des parametres isotropes et anisotropes du laser, l'etude de l'optimisation du couplage de sortie en fonction de la longueur du laser et l'influence d'une contre-reaction optique sur les proprietes statiques et dynamiques du laser.
Subchronic toxicity of propyl paraben in adult male rats

In the current study, daily per os administration of propyl paraben (n-propyl-p-hydroxybenzoate) to adult male rats for four consecutive weeks induced severe hepatotoxicity as revealed by the significant elevation in serum marker enzymes along with a significant decrease in serum protein and its fractions. Furthermore, propyl paraben administration disturbed steroid hormones balance by suppressing serum testosterone level, with a concomitant increase in serum estradiol and an ultimate decrease in testosterone/estradiol ratio. Hepatic and testicular toxicity was furtherly attributed to oxidative stress induction, since propyl paraben altered the oxidant/antioxidant balance in both tissues. Signs of toxicity and histopathological changes in the liver and testes were observed by light microscopy of haematoxylin and eosin-stained sections. In conclusion, our data demonstrate the potency of propyl paraben as an endocrine disruptor to induce disturbances in normal steroid balance in adult male rats. In addition, the induced oxidative stress represents a common mechanism of propyl paraben toxicity in hepatic and testicular tissues. Keywords: Propyl paraben; Testis; Liver; Oxidative stress; Testosterone
Challenges and prospectives for water recycling and reuse in EU countries

Recycled water is a reliable source of water that must be taken into account in formulating a sustainable water policy. Water reuse is a growing field and many projects have been occurring throughout Europe in the last fifteen years. Most of northern EU countries have abundant water resources. In this case, the need for extra supply through the reuse of treated wastewater is not a priority, but the protection of the receiving environment is considered as an important issue. The situation is different in the southern EU countries, where the additional resource brought by water reuse promoted the implementation of a number of new projects. One of the major constraints for water reuse and its public acceptance is the lack of relevant legislation at EU level. As a result of this situation, both strict and flexible standards can be found in Europe, even in the same country (Spain, for example), illustrating an important equity issue, which needs to be addressed.
Impact de Pseudomonas aeruginosa sur Staphylococcus aureus dans un contexte de coexistence bactérienne chez les patients atteints de mucoviscidose

Les poumons des patients atteints de mucoviscidose (CF) sont sequentiellement colonises par Staphylococcus aureus puis par Pseudomonas aeruginosa (PA). Lors de cette colonisation, ces deux bacteries interagissent l’une avec l’autre selon deux modes possibles. Une interaction competitrice, bien caracterisee, est generalement observee dans les co-colonisations precoces ou des produits issus du quorum-sensing de PA ralentissent la croissance de SA et entrainent sa lyse. Une interaction de coexistence, peu caracterisee se produit avec les souches dites tardives de PA qui ne sont plus virulentes envers SA. L’objectif de mes travaux de recherche a ete de caracteriser l’impact de PA sur la physiologie de SA. Des analyses transcriptomiques et confirmations phenotypiques sur des isolats cliniques en coexistence revelent une amelioration de la resistance aux antibiotiques et de l’internalisation de SA dans les cellules de l’hote, en presence de PA. Une approche par Tn-seq a identifie des genes codant de grands regulateurs majeurs de SA (agr, sigB, arlR) comme etant essentiels dans cette interaction de coexistence. Une etude clinique retrospective menee sur la cohorte lyonnaise des patients CF a montre que 65% des patients co-colonises presentaient une paire SA-PA en etat de coexistence. Cette etude note une deterioration pulmonaire dependante du statut infectieux (SA<PA=SA+PA). Mon projet a donc montre que la presence des regulateurs globaux de SA sont importants pour coexister avec PA et de modifier son transcriptome augmentant sa resistance aux antibiotiques et son internalisation. Le caractere poly bacterien des infections devrait etre pris en compte lors des traitements