Miracle-dz/UniFAR-FTUs huggingface dataset:
Hip and Knee Extensor Activation During the Hip Thrust and Rear-Foot–Elevated Split Squat in Trained Females

Abstract McCurdy, K, Walker, J, Kelly, C, and Polinski, M. Hip and knee extensor activation during the hip thrust and rear-foot–elevated split squat in trained females. J Strength Cond Res 35(5): 1201–1207, 2021—The aim of the study was to compare hip and knee extensor muscle activation between the hip thrust (HT) and rear-foot–elevated split squat (RFESS) within different depths and the entire range of motion. Twenty, young adult female subjects (age, 20.9 ± 1.3 years; height, 164.6 ± 7.5 cm; mass 63.2 ± 8.8 kg) with an intermediate level of resistance training experience completed the study. Three repetitions were completed at 80% of the 1-repetition maximum. Gluteus maximus, vastus lateralis, and the medial (semitendinosus and semimembranosus) and lateral (biceps femoris) hamstrings electromyographic data were compared at the top, middle, and bottom one-third of the hip range of motion and for the entire repetition. A repeated-measures analysis of variance was used to test significance set at p ≤ 0.05. All 4 muscles revealed higher (p < 0.001) activation at the top position of the HT compared with the middle and bottom, whereas higher scores (p < 0.001) were found in the bottom position during the RFESS. The HT revealed greater activity (p < 0.001) than the RFESS in all muscles at the top, whereas the RFESS showed higher scores (p < 0.001) than the HT in all muscles in the bottom position. For the entire repetition, the RFESS produce significantly greater vastus lateralis activation (59.4 vs 43.6%). The data indicate that the greatest effect for the HT is demonstrated in the top position and at the bottom for the RFESS. Thus, we recommend to implement both exercises in a training program to maximize gluteus maximus and hamstring activation across the full range of motion. For the greatest vastus lateralis activation, the RFESS is recommended.
Effect of Infant Massage on Salivary Oxytocin Level of Mothers and Infants with Normal and Disordered Bonding

Maternal-infant bonding is an affective maternal-driven process that occurs primarily to her infant. Prophylactic interventions or treatment of disordered bonding include infant massage. Evidence suggests that oxytocin plays an important role in facilitation of mother–infant bonding. Main objective is to assess the effect of infant massage on salivary oxytocin level of mothers and their infant during postpartum period. And to assess the difference of oxytocin level in normal and disordered maternal-infant bonding. This study is a quasi-experimental study, carried out on 37 pairs of mothers and their infants from second to sixth month postpartum, attending Basateen Gharb primary health care center (PHC) in Albasateen district, Cairo, Egypt. Postpartum Bonding Questionnaire (PBQ) was used to differentiate between mothers with normal and disordered bonding. Pre and post massage salivary samples were taken from mothers and their infants. Tappan’s technique of infant massage was used. Results showed that 48.6% (N = 18) of mothers had disordered maternal infant bonding. Mothers and infants with normal bonding showed a positive relationship with their salivary oxytocin level post massage. On the other hand, mothers and infants with disordered bonding showed no change in their salivary oxytocin level post massage. Salivary oxytocin level in male infants has decreased post massage, while oxytocin level in female infants has increased post massage in mothers with normal bonding. We concluded that infant massage increases salivary oxytocin level in mothers and infants with normal bonding and it has no effect on salivary oxytocin level of mothers and infants with disordered bonding.
Cytokinesis regulators as potential diagnostic and therapeutic biomarkers for human hepatocellular carcinoma

Cytokinesis, the final step of mitosis, is critical for maintaining the ploidy level of cells. Cytokinesis is a complex, highly regulated process and its failure can lead to genetic instability and apoptosis, contributing to the development of cancer. Human hepatocellular carcinoma is often accompanied by a high frequency of aneuploidy and the DNA ploidy pattern observed in human hepatocellular carcinoma results mostly from impairments in cytokinesis. Many key regulators of cytokinesis are abnormally expressed in human hepatocellular carcinoma, and their expression levels are often correlated with patient prognosis. Moreover, preclinical studies have demonstrated that the inhibition of key cytokinesis regulators can suppress the growth of human hepatocellular carcinoma. Here, we provide an overview of the current understanding of the signaling networks regulating cytokinesis, the key cytokinesis regulators involved in the initiation and development of human hepatocellular carcinoma, and their applications as potential diagnostic and therapeutic biomarkers.
Solar power enhancement of electrokinetic bioremediation of phenanthrene by Mycobacterium pallens

ABSTRACT Enhanced bioremediation of phenanthrene-contaminated soil with Mycobacterium pallens was conducted. Kaolinite was used in the tests as a soil matrix and was artificially contaminated with phenanthrene at a concentration of 2 mg phenanthrene per gram dry soil. Mycobacterim pallens at concentration of 108 colony-forming units (CFU) per milliliter was used as a potential microorganism to degrade phenanthrene. Aspects of the study included evaluating efficacy of using Mycobacterium pallens for degrading phenanthrene, electrokinetics for delivering nutrients and microorganisms to contaminated soil, and solar panels for generating power for electrokinetic bioremediation. A novel anode-cathode configuration, in which the anode and cathode are placed in the same compartment, was implemented to control/minimize changes in pH during electrokinetic bioremediation. The nutrients (NO3−), electrical current, temperature, Mycobacterium pallens (CFU), and phenatherene concentration were evaluated. The results showed that solar panels generated sufficient power for electrokinetic bioremediation. The highest current obtained was generated when bacteria and nutrients were added to the soil. This was associated with the highest phenanthrene removal from the soil (50% of the initial concentration). Additionally, we determined that the novel anode-cathode configuration in the electrokinetic bioremediation cell was successful in delivering the bacteria and nutrients to the contaminated soil and in maintaining a relatively neutral pH around the electrode compartments, which improved the remediation. Overall, this study showed that the use of solar power with electrokinetic bioremediation can provide a cost-effective approach to reduce and remove hydrocarbon contaminations in soil.
Secondary Ion Mass Spectrometry Imaging Reveals Changes in the Lipid Structure of the Plasma Membranes of Hippocampal Neurons following Drugs Affecting Neuronal Activity

The cellular functions of lipids in the neuronal plasma membranes have been increasingly acknowledged, particularly their association to neuronal processes and synaptic plasticity. However, the knowledge of their regulatory mechanisms in neuronal cells remains sparse. To address this, we investigated the lipid organization of the plasma membranes of hippocampal neurons in relation to neuronal activity using secondary ion mass spectrometry imaging. The neurons were treated with drugs, particularly tetrodotoxin (TTX) and bicuculline (BIC), to induce chronic activation and silencing. Distinct lipid organization was found in the plasma membrane of the cell body and the neurites. Moreover, significant alterations of the levels of the membrane lipids, especially ceramides, phosphatidylserines, phosphatidic acids, and triacylglycerols, were observed under the TTX and BIC treatments. We suggest that many types of membrane lipids are affected by, and may be involved in, the regulation of neuronal function.
The age-invariant role of resilience resources in emotional symptomatology

Abstract Objectives 1) To study the relationship between resilience resources (both social and individual) and emotional symptomatology (depression and anxiety symptoms), taking into account the potential indirect effects through perceived stress; 2) to investigate whether this network of relationships varies in different age groups. Method: A sample of 718 Brazilians completed self-reports on perceived stress, depressive and anxious symptomatology, social support and individual resilience. The sample comprised two age groups: a sample of adults aged 60 or older (n = 361; 38.78% men; M age = 67.32 years, SD age = 5.76, range = 60-86), and a sample of younger adults (n = 357; 29.41% men; M age = 41.37 years, SD age = 7.23, range = 18-59). Multigroup multiple indicator, multiple cause (MIMIC) modelling was used to test for the direct and indirect effects of resilience resources on emotional symptom development, considering the age groups. Results: The relationship between individual resilience resources and depressive or anxiety symptomatology was found to take place exclusively through stressfulness appraisal. On the other hand, social resilience resources showed a direct and indirect effect on emotional symptoms. This pattern of relationships was found to be invariant across age groups. Conclusion: Our findings suggest that both individual and social resilience resources are negatively related to both depressive and anxiety symptoms in adults regardless of age, thus opening the way to future research analysing how interventions may build resilience resources to minimise the influence of stressful and traumatic events across the lifespan.
Screening for pancreatic cancer-a compelling challenge.

The publication of the American Gastroenterology Association (AGA) Clinical Practice Update on Pancreas Cancer Screening in High-Risk Individuals (HRIs) underlines the increasing attention for this topic (1). Secondary prevention (surveillance) for pancreatic ductal adenocarcinoma (PDAC), however, remains a challenge with many unsolved questions (Table 1). Revisiting the ten Wilson-Jungner criteria (2) for appraising a screening program’s validity, when it comes to PDAC most have not been satisfied. Particularly, the fundamental principle that “treatment at an early stage should be of more benefit than at a later stage” has been scarcely investigated. The Johns Hopkins single-center experience reported promising efficacy results in terms of survival, with a median survival of 5.3 years [interquartile range (IQR), 1.2–11.1 years] and an outstanding 85% 3-year survival rate (3). Notably, several studies and some meta-analyses have shown that the diagnostic yield of pre-malignant or malignant lesions in HRIs undergoing screening/surveillance is much higher than the 1.6% lifetime risk of PDAC in unselected individuals. The lifetime risk of PDAC is as high as 40–60% in PeutzJeghers syndrome (PJS) or hereditary pancreatitis (HP) patients, or in the presence of ≥3 first-degree relatives (4-6). However, these reports’ results do not provide evidence of survival benefits over time, leaving the issue of whether a screening/surveillance program for PDAC is effective still unsolved. Who should be screened?
School Leaders’ Opinions, Attitudes, and Performative Actions Toward Teacher Absenteeism in Kenya

The research examined school leaders’ opinions, attitudes, and performative actions toward teacher absenteeism. Existing research has primarily focused on interventions implemented by the Teachers’ Service Commission to curb teacher absenteeism, and yet since leaders are the main agents and their actions are context bound, their actual actions and insights should be accounted for when addressing absenteeism. Our study finds that though teacher absenteeism has been reduced, disheartening challenges persist. The authors recommend continuous monitoring and establishing a mentoring system.
Tracking Risk for Crime Throughout the Day: An Examination of Jersey City Robberies

This study examines temporal variations in the spatial influence of environmental features, such as bars and vacant buildings, on criminal behavior across microlevel places. Specifically, 17 environmental risk factors and their spatial influences are identified for calendar year 2014 street robberies in Jersey City, NJ. To explore temporal variation, risk factors and their spatial influences on crime are identified across 12 discrete 2-hr time intervals. The results demonstrate that the risk factors for street robbery varied across the course of a day. In fact, mapping the most vulnerable places for street robbery revealed that while many of the same environmental features remain high risk throughout the day, their influence varied. These results suggested that there was a temporality to robbery and that it is likely due to the interaction between physical vulnerabilities from the built environment and social behaviors of people at these places. This demonstrates the importance of considering the temporal dimension of criminal behavior as results show that people use and interact with their environment differently throughout the course of the day.
Species Identification and Morphological Trait Diversity Assessment in Ryegrass (Lolium spp.) Populations from the Texas Blackland Prairies

Abstract Ryegrass (Lolium spp.) is a troublesome weed in major wheat (Triticum aestivum L.) production regions in the United States. High diversity and adaptive potential are known to contribute to its success as a weed species and also create difficulties in correct species identification in fields. The objective of this research was to characterize diversity for 16 different morphological traits among 56 Lolium populations collected from wheat production fields across the Texas Blackland Prairies region and identify Lolium species based on taxonomic characteristics. Populations were highly diverse (both at inter- and intrapopulation levels) for the traits studied, and a taxonomic comparison with USDA-GRIN reference samples revealed that all the populations were variants of Italian ryegrass [Lolium perenne L. ssp. multiflorum (Lam.) Husnot] with a few offtypes of perennial ryegrass (Lolium perenne L.) or probable hybrids between the two species. Hierarchical clustering grouped the populations into six clusters based on their similarities for the morphological traits investigated. Principal component analysis showed that the variability for yield traits greatly contributed to the total diversity. Pre-flowering plant height (stage 10 on Feekes scale) was positively correlated with tiller count, shoot biomass, and spike count, but not with total seed count per plant, whereas plant height at maturity (stage 11.3 to 11.4 on Feekes scale) was highly correlated with total seeds per plant. Further, basal node color was positively correlated with plant growth habit, regrowth rate, and leaf color. Leaf blade width was positively correlated with survival to pinoxaden and multiple herbicides, whereas, spike count was negatively correlated with survival to mesosulfuron. The high levels of intra- as well as interpopulation variability documented in this study indicate the potential of this species to rapidly adapt to herbicides and emphasize the need for implementing diverse management tactics, including the integration of harvest weed seed control.
Spectrophotometric Method For The Determination Of Nimodipine In Pharmaceutical Dosage Forms

A simple and sensitive spectrophotometric method has been developed for the determination of nimodipine in bulk and pharmaceutical dosage forms. The method is based on diazotisation of reduced nimodipine with nitrous acid followed by its coupling with I²-naphthol in alkaline medium to form an orange red colored chromogen with an absorption maximum of 555 nm. Good agreement with Beer's law was found in the range of reduced nimodipine concentration of 0-10 I¼g/ml. The optimum reaction conditions and other analytical parameters are evaluated-The proposed method has been successfully applied to the analysis of the bulk drugs and their dosage forms. No interference was observed from talc, starch, dextrose and magnesium stearate in the proposed method. Statistical comparison of the results with those of reported method showed good agreement and indicated no significant difference in precision. This method does not require any extraction or heating.
Generation of Test Cases from UML Diagrams - A Systematic Literature Review

Model-Based testing (MBT) is a technique to derive test cases from models of the system under test (SUT), and the UML is the leading and de-facto standard language for system models both in industry and academia. This paper describes the results of a general systematic literature review (SLR) on the topic of generating test cases based on UML diagrams. By using selection and exclusion criteria, 62 primary studies were chosen from 443 identified publications, which ranged from 1999 to 2019. This study analysed the approaches and outcomes of the reviewed papers. The analysis is mainly focused on the model type, intermediate formats used and coverage criteria. Based on the review results, research trends and deficiencies are identified, and future works are proposed.
Construction and Validation of an Immune Infiltration-Related Gene Signature for the Prediction of Prognosis and Therapeutic Response in Breast Cancer

Breast cancer patients show significant heterogeneity in overall survival. Current assessment models are insufficient to accurately predict patient prognosis, and models for predicting treatment response are lacking. We evaluated the relationship between various immune cells and breast cancer and confirmed the association between immune infiltration and breast cancer progression. Different bioinformatics and statistical approaches were combined to construct a robust immune infiltration-related gene signature for predicting patient prognosis and responses to immunotherapy and chemotherapy. Our research found that a higher immune infiltration-related risk score (IRS) indicates that the patient has a worse prognosis and is not very sensitive to immunotherapy. In addition, a new nomogram was constructed based on the gene signature and clinicopathological features to improve the risk stratification and quantify the risk assessment of individual patients. Our study might contribute to the optimization of the risk stratification for survival and the personalized management of breast cancer.
Pannexin-1 Contributes to the Apoptosis of Spinal Neurocytes in Spinal Cord Injury

Currently, the role of Pannexin-1, a homomeric membrane hemichannel on the neuron cell membrane, in the development of spinal cord injury (SCI) is largely unknown. Herein, we assessed the contribution of Panx1 in the development of SCI. The SCI in vitro model was established using rat primary spinal neurocytes treated with hydrogen peroxide (H2O2). Effects of Panx1 overexpression or depletion in spinal neurocytes were analyzed by lentivirus-mediated transfection of Panx1 and interference sh-Panx1. Decreased cell viability was seen in SCI cells, which was further enhanced under Panx1 overexpression and mitigated by Panx1 deficiency. H2O2 induced an increase of intracellular Ca2+ signal and upregulated level of the proapoptotic protein Bax, and apoptosis pathway proteins including cleaved Caspase-3 and PARP1, which was enhanced by Panx1 overexpression or attenuated by Panx1 depletion. On the other hand, H2O2 treatment suppressed the level of antiapoptotic protein Bcl-2, which was further decreased by Panx1 overexpression or mitigated by Panx1 depletion. The results indicate that Panx1 was involved in the intracellular Ca2+ overload of SCI cells by accelerating extracellular Ca2+ influx, which promoted the apoptosis of spinal neurocytes through Ca2+ dependent pathways, thus aggravating the secondary injury of SCI.
Humor and Fear—Two Sides of the Same Coin?: Experimental Evidence on Humor Appeals in Health Communication Related to Childhood Vaccination

Until now, health communication has largely failed to debunk fears and caveats related to vaccination. This study aims to investigate the effects of different text types used in health communication in an experimental study design. A neutrally formulated text was compared to a humorous text using the formula of a fairytale. Overall, the study indicates no additional value in using the humorous format as an innovative and target-group-oriented approach to inform readers about scientific evidence related to vaccination. Although the effects of the two text types do not differ, the credibility of the neutrally formulated text was much more likely to be judged as high. This indicates that the perception of credibility is not the only criterion in health communication leading to knowledge gains and changes in health-related attitudes and behaviors.
Switching Genes On and Off: How It Can Shape Us

The human body consists of more than 200 different types of cells, but all cells contain the same DNA code. How is it possible that the same code tells the various types of cells to be different? The information for life is not only coded in the DNA, but also on the DNA. Chemical attachments, which are called DNA methylation, can “turn off” parts of the DNA code that are not needed in a specific cell. DNA methylation can also be influenced by our surroundings. Sometimes, changes in DNA methylation might lead to diseases. Understanding how our surroundings can influence DNA methylation might also help us to better understand the mechanisms causing some diseases and hopefully get better at curing and preventing them. This article describes ADHD as one example.
Innovative Approaches in the Battle Against Cancer Recurrence: Novel Strategies to Combat Dormant Disseminated Tumor Cells

Cancer recurrence remains a great fear for many cancer survivors following their initial, apparently successful, therapy. Despite significant improvement in the overall survival of many types of cancer, metastasis accounts for ~90% of all cancer mortality. There is a growing understanding that future therapeutic practices must accommodate this unmet medical need in preventing metastatic recurrence. Accumulating evidence supports dormant disseminated tumor cells (DTCs) as a source of cancer recurrence and recognizes the need for novel strategies to target these tumor cells. This review presents strategies to target dormant quiescent DTCs that reside at secondary sites. These strategies aim to prevent recurrence by maintaining dormant DTCs at bay, or eradicating them. Various approaches are presented, including: reinforcing the niche where dormant DTCs reside in order to keep dormant DTCs at bay; promoting cell intrinsic mechanisms to induce dormancy; preventing the engagement of dormant DTCs with their supportive niche in order to prevent their reactivation; targeting cell-intrinsic mechanisms mediating long-term survival of dormant DTCs; sensitizing dormant DTCs to chemotherapy treatments; and, inhibiting the immune evasion of dormant DTCs, leading to their demise. Various therapeutic approaches, some of which utilize drugs that are already approved, or have been tested in clinical trials and may be considered for repurposing, will be discussed. In addition, clinical evidence for the presence of dormant DTCs will be reviewed, along with potential prognostic biomarkers to enable the identification and stratification of patients who are at high risk of recurrence, and who could benefit from novel dormant DTCs targeting therapies. Finally, we will address the shortcomings of current trial designs for determining activity against dormant DTCs and provide novel approaches.