Miracle-dz/UniFAR-FTUs huggingface dataset:
Study on Synchronization of Brain Waves and Injection Technology

In recent years, the inheritance to the next generation the skills and know-how which the skilled technician has have become problems. In this paper, we focused the inheritance of technology that nurse injected into the patient among that problems. Compared to rookie nurses, it is often said that a skilled nurseâs injection is less degree of pain. It is thought that the reason is that a skilled nurse make a patient relaxed state and reduces the pain of injection. In order to relax the patient state, the authors believe that nurses make themselves relaxed and synchronize their states to the patients. In this paper, we stated the relationship between synchronous and relaxed state in between nurse-patient. In particular, we paid attention to the alpha waves of brain waves to evaluate the state of relaxation, and discussed synchronization of brain waves.
Participación de SINAI en TASS 2016

Resumen: Este art´ıculo describe el sistema de clasiﬁcaci´on de la polaridad utilizado por el equipo SINAI en la tarea 1 del taller TASS 2016. Como en participaciones anteriores, nuestro sistema se basa en un m´etodo supervisado con SVM a partir de vectores de palabras. Dichos vectores se calculan utilizando la t´ecnicas de deep-learning Word2Vec, usando modelos generados a partir de una colecci´on de tweets expresamente generada para esta tarea y el volcado de la Wikipedia en espa˜nol. Nues-tros experimentos muestran que el uso de colecciones de datos masivos de Twitter pueden ayudar a mejorar sensiblemente el rendimiento del clasiﬁcador. Palabras clave
Oxaliplatin-induced Evan's syndrome

Sir, Oxaliplatin is a third-generation platinum compound with activ in advanced colorectal cancer. It is available in several Euro countries, but remains investigational in North America. Its sa profile compares favourably with the other platinum-based ag cisplatin and carboplatin, and consists mostly of periph neuropathy and mild thrombocytopenia. However, there has one previous report in the literature of fatal haemolytic anae caused by oxaliplatin (Desrame et al, 1999). Here we re immune-mediated thrombocytopenia and concurrent haemo anaemia (Evan’s syndrome) that developed during oxalip infusion. In November of 1999, a 56-year-old man with a 2-year his of colon cancer metastatic to liver and lung, who had progre on first-line 5-FU and leucovorin as well as second-line irinote was enrolled on a Phase II study at the Dana-Farber C Institute. Treatment consisted of oxaliplatin 85 mg/m 2 by bolus infusion over 2 hours, followed by 500 mg/m 2 of leucovorin also infused over 2 hours, 5-FU 400 mg/m 2 by rapid venous infusion and then 5-FU 2400 mg/m 2 by continuous infusion with a portab pump over 46 hours. Treatment was repeated every 2 weeks patient had stable disease on this regimen between Nove 1999 and July 2000. In July, the patient came for a routine treatment with a pla count of 99 000 μl–1 immediately prior to infusion. During th leucovorin infusion, approximately 5 hours after the base bloodwork was drawn and the oxaliplatin infusion initiated, began feeling unwell and his gums began to bleed. He s quently developed purpura on his oral mucosa and eyelids, ha turia and haematochezia. A repeat platelet count was 6000 μl–1.He remained haemodynamically stable throughout, and initial hae globin and INR were normal. He was admitted to hospital platelet transfusion and supportive care, but quickly also de oped anaemia with a drop in his haemoglobin from 108 to 78 –1.
An Efficient Method for Breast Mass Segmentation and Classification in Mammographic Images

According to the World Health Organization, breast cancer is the main cause of cancer death among women in the world. Until now, there are no effective ways of preventing this disease. Thus, early screening and detection is the most effective method for rising treatment success rates and reducing death rates due to breast cancer. Mammography is still the most used as a diagnostic and screening tool for early breast cancer detection. In this work, we propose a method to segment and classify masses using the regions of interest of mammographic images. Mass segmentation is performed using a fuzzy active contour model obtained by combining Fuzzy C-Means and the Chan-Vese model. Shape and margin features are then extracted from the segmented masses and used to classify them as benign or malignant. The generated features are usually imprecise and reflect an uncertain representation. Thus, we propose to analyze them by a possibility theory to deal with imprecise and uncertain aspect. The experimental results on Regions Of Interest (ROIs) extracted from MIAS database indicate that the proposed method yields good mass segmentation and classification results.
以狄式分佈為基礎之多語聲學模型拆分及合併 (Multilingual Acoustic Model Splitting and Merging by Latent Dirichlet Allocation) [In Chinese]

To avoid the confusion of phonetic acoustic models between different languages is one of the most challenges in multilingual speech recognition. We proposed the method based on Latent Dirichlet Allocation to avoid the confusion of phonetic acoustic models between different languages. We split phonetic acoustic models based on tri-phone. And merging the group that selected by Latent Dirichlet Allocation Detector to solve pronunciation variants problems between different languages. This paper has three parts. First part is introduced the Pronunciation Event and Articulatory Features. Second part is about Latent Dirichlet Allocation and the acoustic model selecting method using Latent Dirichlet Allocation. Latent Dirichlet Allocation is a Hierarchical math model that proposed by David M. Blei at 2003. It is often used on documents classification and document generation. The structure of LDA is also suitable for speech recognition and nature language processing. The final is experiment result and verification the method we proposed.
Non-steroidal anti-inflammatory drug-induced gastroduodenal toxicity and Helicobacter pylori.

Non-steroidal anti-inflammatory drugs including aspirin are commonly prescribed drugs, especially in the elderly. In the United States, aspirin and other NSAIDs were responsible for 60% of all orally used analgetics in the year 2000. It is well documented that the use of these drugs increases the risk for gastroduodenal toxicity. The expense of hospitalizations for gastrointestinal complications comprised about 66% of the total cost of the NSAIDs used [1]. Concomitant medications that were prescibed to prevent gastroduodenal toxicity added to the cost. Factors increasing the risk of gastrointestinal toxicity due to NSAIDs include: dose and type of NSAID, history of peptic ulcer, age above 60, concomitant use of anticoagulants, other concurrent illnesses such as ischemic heart disease or diabetes mellitus, and longer duration of NSAID exposure. Two large-scale studies showed that cyclooxygenase-2-selective NSAIDs caused fewer upper gastrointestinal events than the non-selective NSAIDs, although they were not free of these side effects [2,3]. Different approaches have been used to minimize NSAID-related toxicity and adverse events. These include the preferential use of nonNSAID analgesics or COX-2 selective inhibitors, prescribing the lowest effective dose, or use of anti-acid co-therapy in case of non-selective NSAIDs. From the clinical point of view one of the main questions is whether Helicobacter pylori-infected patients receiving NSAIDs or aspirin are prone to increased risk of gastroduodenal pathology. In this scenario, eradication of H. pylori in these patients could decrease upper GI side effects, suggesting this approach as an alternative to anti-acid therapy.
BER comparison of DCT-OFDM and DFT-OFDM for different modulation techniques in multipath Rayleigh fading environment

In wireless communication Orthogonal Frequency Division Multiplexing is gaining its importance as it is suitable for high speed data rates. It is a multi carrier system, which is commonly implemented for transmission of signals nowadays. In this system, orthogonally placed sub-carriers are used to carry data from transmitter end to receiver end. In this paper, Bit Error Rate comparison of Discrete Fourier Transform-based Orthogonal Frequency Division Multiplexing is compared with Discrete Cosine Transform-based Orthogonal Frequency Division Multiplexing for different modulation techniques over Multipath Rayleigh Fading Channel. It is observed from results that, Bit Error Rate shift in case of Discrete Cosine Transform-based Orthogonal Frequency Division Multiplexing is less then compared to Bit Error Rate shift in case of Discrete Fourier Transform-based Orthogonal Frequency Division Multiplexing system and Quadrature Amplitude Modulation shows better performance as compared to Phase Shift Keying for higher constellation index.
We Live in a Motorized Civilization: Robert Moses Replies to Robert Caro

In 1974, Robert Caro published The Power Broker, a critical biography of Robert Moses’s dictatorial tenure as the “master builder” of mid-century New York. Moses transformed the urban fabric and transportation system of New York in a profound way, producing the Brooklyn Battery Tunnel, the Verrazano Narrows Bridge, the Westside Highway, the Cross-Bronx Expressway, the Lincoln Center, the UN headquarters, Shea Stadium, Jones Beach State Park and many other projects. However, The Power Broker did lasting damage to his public image and today he remains one of the most polarizing figures in city planning history. On August 26, 1974, Moses issued a 23-page typed statement denouncing Caro’s work as “full of mistakes, unsupported charges, nasty baseless personalities, and random haymakers. ” The statement went on to gainsay several of Caro’s assertions one at a time. Robert Moses’s typewritten response survives today as a grainy photocopy from the New York City Parks Department archive. To better preserve and disseminate it, I have extracted and transcribed its text using optical character recognition, and edited the result to correct transcription errors.
Anterior Cruciate Ligament Reconstruction with Autogenous Patellar Tendon Graft Followed by Accelerated Rehabilitation

We sought to determine the long-term results of 1057 consecutive patients who underwent an anterior cruci ate ligament reconstruction with an autogenous patel lar tendon graft from 1987 through 1993 and who followed an accelerated rehabilitation program. The patients were followed prospectively and objective physical examination data were obtained on 806 pa tients at a mean of 4.0 years postoperatively. Subjec tive follow-up data were obtained on 948 patients at a mean of 4.4 years postoperatively. The mean final range of motion was 5°/0°/140°. The mean manual maximum KT-1000 arthrometer score was 2.0 ± 1.5 mm. Isokinetic quadriceps muscle strength testing re vealed a mean of 94% strength after acute reconstruc tions and 91% strength after chronic reconstructions. International Knee Documentation Committee evalua tion after acute reconstruction rated 42% of knees as normal, 47% as near normal, 10% as abnormal, and 1% as severely abnormal. The same evaluation after chronic reconstruction rated 41% of knees as normal, 44% as near normal, 14% as abnormal, and 1% as severely abnormal. Radiographically, 94% of acute knees and 89% of chronic knees had no joint space narrowing. Subjective modified Noyes questionnaire results showed a mean score of 93.2 ± 7.9 points. The mean time for patients to return to sport-specific activ ities was 6.2 weeks and to athletic competition at full capacity was 6.2 months postoperatively. In the long- term, patients exhibited full range of motion, excellent stability, good strength, and a return of full function in most cases.
Polynomial ring transforms for efficient XOR-based erasure coding

The complexity of software implementations of MDS erasure codes mainly depends on the efficiency of the finite field operations implementation. In this paper, we propose a method to reduce the complexity of the finite field multiplication by using simple transforms between a field and a ring to perform the multiplication in a ring. We show that moving to a ring reduces the complexity of the operations. Then, we show that this construction allows the use of simple scheduling to reduce the number of operations.
Modeling of threading dislocation reduction in growing GaN layers

In this work, a model is developed to treat threading dislocation (TD) reduction in (0 0 0 1) wurtzite epitaxial GaN thin films. The model is based on an approach originally proposed for (0 0 1) FCC thin film growth and uses the concepts of mutual TD motion and reactions. We show that the experimentally observed slow TD reduction in GaN can be explained by low TD reaction probabilities due to TD line directions practically normal to the film surface. The behavior of screw dislocations in III-nitride films is considered and is found to strongly impact TD reduction. Dislocation reduction data in hydride vapor phase epitaxy (HVPE) grown GaN are well described by this model. The model provides an explanation for the non-saturating TD density in thick GaN films. r 2001 Elsevier Science B.V. All rights reserved.
Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma.

PURPOSE The primary causative factor of primary open-angle glaucoma (POAG) is elevated intraocular pressure (IOP) due to increased aqueous humor (AH) outflow resistance, which is associated with morphologic and biochemical changes in the trabecular meshwork (TM). Patients with glaucoma have elevated levels of transforming growth factor (TGF)-beta2 in their AH, and TGF-beta has been shown to increase TM extracellular matrix (ECM) production. The bone morphogenetic protein (BMP) signaling pathway modifies TGF-beta signaling in several different tissues, and a prior study demonstrated that TM cells and tissues express members of the BMP gene family. The purpose of this study was to determine whether BMPs can alter TGF-beta2 signaling in the TM and whether there are defects in BMP signaling in glaucoma. METHODS ELISA, Western immunoblot analysis, and immunohistochemistry were used to evaluate the expression of BMP proteins in TM cells and tissues. ELISA was used to determine the effects of TGF-beta2 and BMPs on TM fibronectin (FN) secretion. Gene expression was determined by gene microarrays and quantitative (q)PCR. Perfusion-cultured human anterior segments were used to study the effects of altered BMP signaling on IOP. RESULTS The human TM synthesized and secreted BMP-4 as well as expressed BMP receptor subtypes BMPRI and BMPRII. TM cells responded to exogenous BMP-4 by phosphorylating Smad signaling proteins. Cultured human TM cells treated with TGF-beta2 significantly increased FN levels, and BMP-4 blocked this FN induction. The expression of BMP family genes in normal and glaucomatous TM cells was profiled and significant elevation of mRNA and protein levels of the BMP antagonist gremlin were found in glaucomatous TM cells. In addition, Gremlin was present in human aqueous humor and in the perfusate medium of perfusion-cultured human eyes. Gremlin blocked the negative effect of BMP-4 on TGF-beta-induction of FN. Recombinant Gremlin added to the medium of ex vivo perfusion-cultured human eye anterior segments caused the glaucoma phenotype of elevated IOP. CONCLUSIONS These results are consistent with the hypothesis that, in POAG, elevated expression of Gremlin by TM cells inhibits BMP-4 antagonism of TGF-beta2 and leads to increased ECM deposition and elevated IOP.
DNA metabolism in mycobacterium tuberculosis: implications for drug resistance and strain variability.

In this paper, we review the evidence supporting the notion that the genome of Mycobacterium tuberculosis sustains considerable damage as a result of exposure to nitrosative and oxidative stress. On these grounds, we propose a model in which stress-induced DNA damage in M. tuberculosis plays a role in the evolution of chromosomally encoded drug resistance mutations by altering the global mutation rate by mechanisms akin to SOS mutagenesis. Finally we review some of the factors determining the evolution of PE/PPE and MIRU (There are many abbreviations in this paper which are not defined, e.g. SOS, PE/PPE and MIRU. Please indicate whether these are well known and will be understood by readers or whether they should be defined at first mention) loci whose sequence characteristics are suggestive of their classification as heritable local mutators.
Therapeutic Potential of Antisense Nucleic Acid Molecules

Elucidation of many disease-related signal transduction and gene expression pathways has provided unparalleled opportunities for the development of targeted therapeutics. The types of molecules in development are increasingly varied and include small-molecule enzyme inhibitors, humanized antibodies to cell surface receptors, and antisense nucleic acids for silencing the expression of specific genes. This Perspective reviews the basis for various antisense strategies for modulating gene expression, including RNA interference, and discusses the prospects for their clinical use.
Toward a Functional View of the p Factor in Psychopathology

Evidence indicates the existence of a superordinate factor of general psychopathology, which has been termed p. Among the issues raised by this discovery is whether this factor has substantive meaning or not. This article suggests a functional interpretation of the p factor, based in part on a family of dual process models, in which an associative system and a deliberative system compete for influence over action. The associative system is frequently said to be impulsively responsive to emotions. We hypothesize that this impulsive responsivity to emotion underlies the p factor. One benefit of this view is to use the same underlying process variable to account for both internalizing and externalizing vulnerabilities as well as aspects of thought disorder. Evidence is reviewed linking impulsive reactivity to emotion to the p factor and (separately) to internalizing, externalizing, and thought-disorder symptoms. Alternative interpretations are considered.
Manifold regularization Multiple Kernel Learning machine for classification

Recently, Multiple Kernel Learning (MKL) is an interesting research area in kernel machine applications and provides better interpretability and adaptability. Previous works have not considered much about the data itself, especially the intrinsic geometry information of data which is possible being beneficial for machine learning. We propose a manifold regularized multiple kernel machines to use the manifold regularization term to explore the inner geometry distribution of data. In fact, there are some real datasets being embedded in low dimensional manifold being undeveloped or hard to be seen. So adding the manifold regularization term to the original MKL is based on the assumption that the data geometrical distribution information may help to get a proper learning machine performance. We use properties of reproducing kernel Hilbert spaces (RKHS), Representer Theorem and Laplacian Graph method to provide theoretical basis for the algorithm. In experiments, classification accuracies of the algorithm and its ability to represent potential low dimensional manifold are given. Testing results suggest that our proposed method is able to yield competent classification accuracy and worth pursuing further research works.
N 00014-94-C-0149 TECHNICAL REPORT 96-07 INCREASED PLATELET REACTIVITY AND CIRCULATING MONOCYTE-PLATELET AGGREGATES IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE

Background Platelet-dependent thrombosis and leukocyte infiltration into the vessel wall are characteristic cellular events seen in atherosclerosis. We examined whether patients with stable coronary artery disease (CAD) have increased platelet reactivity and an enhanced propensity to form monocyte-platelet aggregates. Methods and Results Anticoagulated peripheral venous blood from 19 patients with stable CAD and 19 normal controls was activated with or without various platelet agonists and analyzed by whole blood flow cytometry. Circulating degranulated platelets were increased in patients with CAD compared to controls (2.1 ± 0.2 [mean ± S.E.M.] vs. 1.5 ± 0.2, % P-selectin positive platelets, p<0.01) and were more reactive to stimulation with ADP 1 uM (28.7 ± 3.9 vs. 16.1 ± 2.2, p<0.01), ADP/epinephrine 1 uM (51.4 ± 4.6 vs. 37.5 ± 3.8, p<0.05), or thrombin receptor agonist peptide (TRAP) 5 uM (65.7 ± 6.8 vs. 20.2 ±5.1, p<0.01). Patients with stable CAD also had increased circulating monocyte-platelet aggregates compared to controls (15.3 ± 3.0 vs. 6.3 ± 0.9, % platelet-positive monocytes, p<0.01). Furthermore, patients with stable CAD formed more monocyte-platelet aggregates than controls when their whole blood was stimulated with ADP 1 uM (50.4 ± 4.5 vs. 28.1 ± 5.3, p < 0.01), ADP/epinephrine 1 uM (60.7 ± 4.3 vs. 48.0 ± 4.8, p < 0.05), or TRAP 5 uM (67.6 ± 5.7 vs. 34.3 ± 7.0, p<0.01). Compared to controls, patients with stable CAD did not have a significant increase in circulating neutrophil-platelet aggregates or circulating activated monocytes. Conclusion Patients with stable CAD have circulating activated platelets, circulating monocyteplatelet aggregates, increased platelet reactivity, and an increased propensity to form monocyte-platelet aggregates. Abbreviated Abstract As determined by whole blood flow cytometry, patients with stable coronary artery disease have circulating activated platelets, circulating monocyte-platelet aggregates, increased platelet reactivity, and an increased propensity to form monocyte-platelet aggregates.
Planification stratégique d'une Supply chain sous contraintes d'incertitude : affectation de la production et dimensionnement des ressources. (Strategic planning of a Supply chain under constraints of uncertainty : production allocation and ressources desing)

Ce doctorat a porte, pour partie, sur une problematique derivee du cas de la Supply Chain Tourisme Camionnette Europe de la societe Michelin. Celle-ci a ete formulee comme un probleme d’Affectation Strategique des Productions et de Dimensionnement des Ressources ainsi que de la Flexibilite (ASPDRF) du systeme de production d’une Supply Chain dans un contexte incertain. Ce probleme ASPDRF presentant un certain nombre de specificites rendant impossible le recours a des methodes existantes ; un modele lineaire dedie ainsi qu’une metaheuristique de type « Greedy Randomized Adaptative Search Procedure » (GRAPS) ont ete construits. Cette derniere a permis l’obtention de resultats de bonnes qualites et industriellement exploitables et, ce, meme dans le cas d’instances de tres grandes tailles ; instances ne pouvant etre resolues par le recours a la programmation lineaire. Ceci constitue, en plus de l’originalite de certaines contraintes considerees, l’un des apports de ces travaux de doctorat vis-a-vis de la thematique du Supply Chain Network Design a laquelle ils se rattachent. Au-dela de la resolution du probleme ASPDRF, ces travaux de doctorat ont egalement portes sur la realisation d’un environnement integre de planification couvrant les horizons strategique, tactiques et operationnels ainsi que les differentes boucles de retroaction associees. Celui-ci a pour vocation d’apporter une aide au manager lors des differentes etapes de prises de decisions associees a ces horizons de planification. Cet environnement, constitue du GRASP propose ainsi que de modeles de flot et de modeles lineaires specifiques, presente lui aussi la particularite de pouvoir adresser des problemes de grandes tailles.