Miracle-dz/UniFAR-FTUs huggingface dataset:
A predictive and prognostic biomarker profile of carcinoma breast

Context: The immunohistochemical (IHC 4) biomarker profile is part of the standard histopathology report of all newly diagnosed and recurrent cases of carcinoma Breast. This profile is the basis for all neoadjuvant and adjuvant treatment planning in these cases. Aims: 1. To study the IHC4 biomarker profile of Carcinoma Breast cases at our Institute. 2. To study the correlation of the five types of molecular subgroups with various clinical and histological parameters. Settings and Design: 271 cases of carcinoma breast diagnosed and treated at our Institute, during the period 1st July 2017 till 30th June 2018. This is a prospective, observational study. Materials and Methods: All the cases of biopsy proven carcinoma Breast were subjected to immunohistochemical staining for four markers- ER, PR, Her 2, and Ki 67. Fo rmalin Fixed Paraffin Embedded tumor tissue was stained for 4 biomarkers and scored with appropriate method. (Interpretive Guide: ASCO - CAP Test Guidelines Recommendations 2013) Manual method of staining was employed, using commercially available reagents. The cases were classified into five molecular subtypes. Results: Triple negative breast carcinoma was the most frequent subgroup, followed by the luminal B and A types and the Her2 enriched cases were lowest in number. A few cases showed triple positive staining pattern. Conclusions: The IHC 4 biomarker findings in every case of carcinoma has a direct impact on the treatment decision making and also on risk stratification of the patients. Keywords: IHC 4, ER, PR, Her2, Ki67, Carcinoma breast.
Managing sickness absence

Background: Frequent short sickness absences result in understaffing and interfere with work processes. We need more knowledge about factors associated with this type of absence. Purpose: To investigate associations between the frequency of previous sickness absence and self-reported perceptions of health and work. Methods: Cross-sectional study of female hospital care workers in which health, work characteristics and coping styles were assessed by questionnaire and linked to the number of sickness absence episodes recorded in the preceding 5-years using negative binomial regression analysis for counts distinguishing between short (1-7 days) episodes and long (> 7 days) episodes of absence after adjusting for age and duration of employment in December 2007 and hours worked between 2003 and 2007. Results: Of 350 women employed for at least 5 years, 237 (68%) answered the questionnaire. The hours worked over the 5 year period (rate ratio [RR]=1.2) and problem-solving coping style score (RR=1.1) were positively associated with the number of short sickness absence episodes. Age (RR=0.8) and good general health (RR=0.7) were inversely related to the number of both short and long sickness absence episodes. Self-reportes mental health and work characteristics were not shown to be related to the frequency of sickness absence. Conclusions: Hours worked, problem-solving coping style, age and general health showed associations with the frequency of previous sickness absence among women who had worked at least 5 years in health care. Future prospective studies on the frequency of sickness absence should consider the impact of these factors further. Schreuder (thesis). indd 36 23-08-12 13:11
A New Population Theory:

With the aim to improve the global governmental and civil society based population policy approaches, this paper goes beyond addressing cognitive drivers of fertility rates to explore the relationship between poverty and human security, and the influences of human survival instincts. It responds to deeper questions, "why or what causes these social-economic factors to exist? " and "for what biological, evolutionary purpose? " It presents a theory concerned with environmental influences of human insecurity on fertility rates and population growth, beyond influences of contraceptive prevalence or the cost of education on reproductive behavior.
Monitoring Disease Status in Multiple Myeloma in View of Proliferation-leading Cytokines

Interleukin-6 (IL-6) is a major proliferative factor for malignant plasma cells. Interleukin-6 produces by the malignant plasma cells (endogenous production/autocrine regulation mechanism) and by bone marrow stromal cells (exogenous production/paracrine regulation mechanism). Interleukin-6 exerts its biological function through binding to specific receptors on the membrane: (1) Interleukin-6 receptor alpha (IL-6R, also called CD126) and (2) signal-transducing component gp130 (also called CD130). The complex IL-6 + IL-6R + gp130 activate the intracellular signaling cascades: JAKs (Janus Kinases) and STATs (Signal Transducer-Activator of Transcription) and the RAS/MAPKs (RAS/mitogen activated protein kinase) pathways.
Effect of Different Dietary Lipid Levels on Spawning Performance and Egg Quality of Pangasianodon

Dietary lipid manipulation of broodstock diet offers a strategy for improving spawning performance and egg quality of broodstock fish. Although many studies were conducted on basic nutrient requirements for fingerlings and juveniles of Pangasianodon hypophthalmus (Sauvage, 1878); the artificial feed for P. hypophthalmus broodstock is still lacking. This study analysed the effect of different levels of lipid in the diet on spawning performance and egg quality of female P. hypophthalmus broodstock. Three test diets were formulated containing 1:1 ratio of palm oil and fish oil blends at the level of 60, 90 and 120 g.kg-1 with a constant 300 g.kg-1 protein and fed to triplicate groups of female broodstock for 150 days at the rate of 20 g.kg-1 body weight twice daily. The ovary weight, gonadosomatic index, fecundity, egg weight and diameter and egg fertilisation rate were significantly (P < 0.05) increased for fish fed with 90 and 120 g.kg-1 lipid diet compared to 60 g.kg-1 lipid diet. However, there was no significant difference between fish fed with 90 and 120 g.kg-1 lipid diet; thus an increase in dietary lipid above 90 g.kg-1 would not make any significant contribution. The increased performance of female broodstock fed with higher dietary lipid and fish oil at the ratio of 1:1 for crude palm oil and fish oil up to 90 g.kg-1 contributed in the enhancement of the reproductive performance and egg quality of P. hypophthalmus.
Macroeconomic Effects of Gender Gaps in Entrepreneurship: frictions vs. selection∗ PRELIMINARY AND INCOMPLETE. PLEASE DO NOT CIRCULATE

This article studies the aggregate effects of the existing differences betweenmale and female-run firms. We document that only about one fourth of the total firms are run by women and that female-run firms are about three times smaller than male-run firms. We then propose two theoretical frameworks based on Cuberes and Teignier (2016) to incorporate these facts and quantify their aggregate effects on productivity and income per capita. In the first framework, more talented women are more likely to face barriers to become firm managers, which implies a negative selection of female managers and, consequently, a smaller size of female-run firms relative to those managed by men in equilibrium. For the Latin America case, we obtain an output per capita loss due to these gender gaps is 9%, which is 1.3 times larger than the one obtained in a framework where barriers to entrepreneurship are independent of talent. In the second framework, women face frictions to access the productive inputs and have to pay a higher price to hire these inputs, which leads to smaller female-run firms relative to male-run firms. JEL classification numbers: E2, J21, J24, O40.
Safety and Efficacy of High-flow Nasal Cannula Therapy in the Pediatric Emergency Department

Öz DOI: 10.4274/cayd.galenos. 2019.46338 J Pediatr Emerg Intensive Care Med 2019;6:121-129 Ali Yurtseven1, Eylem Ulaş Saz1, Halim Hennes2 1Ege University Faculty of Medicine, Department of Pediatrics, Division of Emergency Medicine, İzmir, Turkey 2University of Texas, Southwestern Medical Center, Department of Pediatric Emergency, Texas, USA Review / Derleme 121 Address for Correspondence/Yazışma Adresi: Ali Yurtseven, Ege University Faculty of Medicine, Department of Pediatrics, Division of Emergency Medicine, İzmir, Turkey E-mail: aliyurtseven1605@gmail.com ORCID ID: orcid.org/0000-0002-8302-0204 Received/Geliş Tarihi: 04.07. 2019 Accepted/Kabul Tarihi: 09.09. 2019 Copyright 2019 by Society of Pediatric Emergency and Intensive Care Medicine Journal of Pediatric Emergency and Pediatric Intensive Care published by Galenos Yayınevi.
DERIVATION OF AN ORTHOGONAL SET OF FUNCTIONS FOR HEMISPHERICAL MICROPHONE ARRAYS

Spherical microphone arrays allow sound field extrapolation using spherical harmonic expansion. Orthogonality of spherical harmonic functions is a key property to perform sound field extrapolation. When measuring the surface impedance of plane materials, it can be convenient to use a hemispherical array whose equatorial plane is set on the material of interest. In that case, spherical harmonics cannot be used, as orthogonality of the spherical basis does not hold on a half-space. When the hemispherical array of microphones is located above a surface with non-trivial boundary conditions (not Neumann or Dirichlet) a closed-form, orthogonal solution of the wave equation in spherical coordinates does not exist. This paper presents a revisited version of a classical numerical approach to derive orthogonal, hemispherical solutions of the wave equation for non-trivial boundary conditions on the equatorial plane. This theory derives such solutions as a combination of spherical harmonics in the restricted hemispherical range, leading to the so-called spherical Slepian functions. Such a functional basis allows to accurately extrapolate the sound field of a source at an arbitrary position in free field using a direct frequency independent matrix. It is also shown that the high frequency limitations of the method are related to the spatial sampling of the hemisphere, while measurement noise impacts accuracy in low frequency. Finally, simulation results are presented for a hemispherical array above an acoustically absorbing plane material, with the objective of identifying the surface impedance of the material.
REAL TIME ANALOGUE SELF TRACKING RECEIVE ANTENNA COMPATIBLE WITH INMARSAT BGAN MODULATION SCHEMES

This paper presents first practical results for a retrodirective array tracking off-air signals from Inmarsat BGAN. The antenna employs analogue phase conjugation, which offers real time tracking on receive, with minimum complexity and low power consumption. The retrodirective circuits are shown to be able to track very weak Inmarsat BGAN global beam signals, at levels as low as -130dBm per element. The challenges in phase tracking QPSK/16QAM modulation schemes are also overcome, with tracking performance similar, or better than, previously reported architectures which could only track CW signals.
A GAUGE TRANSFORMATION THEORY FOR METAMATE- RIALS

Veselago’s concept of negative permittivity and negative permeability also satisfy the dispersion relation of electromagnetic waves, giving rise to the form of artificial material known as metamaterials. This negativity property gives rise to negative lens able to capture the evanescent waves. However, the dispersion relation is unable to produce the phenomenon of cloaking which has to depend on coordinates transformation producing the bending of path of electromagnetic waves with no change in the form of the electromagnetic field equations. It was shown by Woon Siong Gan that both negative refraction and cloaking can be unified under the theory of coordinates transformation or gauge transformation. In fact negative refraction is a special case of cloaking when the transformation matrix equals 1. Subsequently it was shown that both negative refraction and cloaking can occur also in quantum metamaterial, an entirely different field from classical metamaterial proposed by Veselago. In quantum metamaterial the dispersion relation does not give rise to negative permittivity and negative permeability. The gauge transformation theory has to be used. There are many similarities between electromagnetic waves and acoustics waves, so the electromagnetic metamaterial has also been extended to acoustic metamaterial. But sofar there has been no quantum acoustic metamaterial. So there is tremendous potential in exploring this new field. For the acoustic metamaterial, the permittivity and permeability of em waves are analogous to the bulk modulus and the mass density of acoustic waves respectively.
Survey on Data mining Algorithm used for Heart Disease Prediction

— Data mining is one of the richest areas of research that is more popular in health organizations. Data mining plays an effective role for uncovering new trends in healthcare organization which is helpful for all the parties associated with this field. Heart disease is the leading cause of death in the world over the past 10 years. Heart disease is a term that assigns to a large number of medical conditions related to heart. These medical conditions describe the irregular health condition that directly affects the heart and all its parts. The healthcare industry gathers enormous amount of heart disease data which are not “mined” to discover hidden information for effective decision making. Data mining techniques are useful for analyzing the data from many different dimensions and for identifying relationships. This paper explores the utility of various decision tree and neural network algorithms to classify and predict the disease.
Database Security and the Role of Cipher

– In this digital world of e-commerce data repositories is an attraction for attackers. Generally, conventional database security systems have some lose points that can be used by attackers to penetrate the database. Database security could be enhanced by encryption algorithm or ciphers to give protection to the database from various threat or hackers who target to get confidential information. This paper analyse various ciphers used for encrypting data in the database.
Low JAK2 V617F Allele Burden in Primary Myelofibrosis, Compared to Either a Higher Allele Burden or Unmutated Status, Predicts Inferior Overall and Leukemia-Free Survival.

Background : Two previous studies have reported significant but inconsistent associations between the presence of JAK2 V617F in primary myelofibrosis (PMF) and older age at diagnosis, risk of thrombosis, higher leukocyte count, and inferior survival (Tefferi, et al. BJH 2005;131:320, Campbell, et al. Blood 2006;107:2098). The clinical relevance of V617F allele burden in PMF has not been previously studied. Methods : Diagnosis of PMF was based on the World Health Organization criteria and study eligibility included the availability of bone marrow-derived DNA that was collected either at time of diagnosis or within one year of diagnosis. Quantitative allele specific PCR was utilized to meaure V617F allele burden. Results I. V617F-positive vs. V617F-negative comparisons: A total of 199 patients (60% males; median age 61 years) were suitable for analysis of comparisons between mutation-positive and mutation-negative disease. The Dupriez prognostic scoring system (PSS) risk distributions were 61% low-risk, 31% intermediate-risk, and 8% high-risk. Hypercatabolic symptoms were present in 27% of the patients and ≥1% peripheral blood (PB) blasts in 37%. At a median follow-up of 23 months (range 0–266), 57 patients (29%) had died, 17 (9%) developed leukemic transformation (LT) and 10 (5%) experienced major thrombosis. V617F mutational frequency was 58%. Univariate analysis identified older age (p=0.0007), platelet count ≥ 100 x 10 9 /L (p=0.05), and PB blast percentage Results II. Clinical correlates of V617F allele burden: Quantitative measurement of V617F allele burden was performed in 129 patients that were divided into four groups: V617F-negative (n=53) and V617F-positive with mutant allele burden in the lower quartile (n=19), middle quartiles (n=38), or upper quartile (n=19) range (median and range of V617F allele burden ratio was 29% and 1% to 74%). Kaplan-Meier plots revealed significantly shortened overall (Figure; p = 0.0008) and leukemia-free (p = 0.01) survival for the lower quartile allele burden group; survival significance was sustained in a multivariable analysis that included the Dupriez PSS. Lower quartile allele burden was also associated with lower leukocyte count (p = 0.003) and presence of hypercatabolic symptoms (p=0.05). Thrombosis incidence was not affected by allele burden. Conclusions: In PMF, patients with a low V617F allele burden, compared to those with either undetectable (i.e. wild-type) or higher allele burden, display significantly shorter overall and leukemia-free survival. In contrast, the presence or absence of the mutation, by itself, does not result in distinct groups that differ significantly in terms of survival, LT, or incidence of thrombosis. These data suggest that a low V617F allele burden in PMF is a surrogate for the development of dominant V617F-negative subclones that are more likely to undergo LT.
The Impact of Policy and Technology Parameters on the Economics of Microgrids for Rural Electrification: A Case Study of Remote Communities in Bolivia

Throughout the developing world, most remote and isolated communities are still without reliable electricity in the twenty-first century, and this is primarily due to the high cost of grid extensions. In communities that do have electricity, they usually rely on diesel generators, though these have high operating and maintenance costs, while also polluting the environment. A more sustainable approach is to deploy microgrids, however, microgrids have a high upfront cost, which is a major obstacle, especially in rural areas of developing countries. This study aims to investigate the parameters that can be influenced to make microgrids more economical for rural electrification. Through sensitivity analyses, five key policy and technology parameters were identified. They include real discount rates, diesel prices, grants, battery chemistry, and operating strategies. The system was then redesigned using scenarios formulated by varying these parameters. Results show that the parameters affect the configuration, levelized cost of energy (LCOE), renewable energy penetration (REP), and pollutant emissions. The study uses three remote communities in the Beni Department of Bolivia as case studies. MDSTool was used as a modeling framework to design the microgrids. The unique insights and lessons learned during the design process are discussed at length because these may be valuable for future microgrid designs for remote communities.
Experiential Avoidance in Obsessive-Compulsive Disorder Therapy. Case Study

Introduction: In the practical field of psychotherapy we frequently have to deal with a complex pathology. Sometimes it is difficult to detect the causes for a specific pathology or to identify the main pathology and the secondary ones. This derives from the complexity of the human psyche and sometimes it is conditioned by the period of time during which this pathology has evolved. Objectives: In the case we are going to present, the pathology has a long history with adolescence onset and it seems that obsessive-compulsive symptoms were developed either as a particular manner of dealing with negative family experiences or as a manner of avoiding the necessity to deal with this kind of experiences. Method: In this particular case, the obsessive-compulsive pathology found a way to express itself in a graphic-plastic manner that helped the patient experience a new way of understanding and curing himself. Additionally, we will present some personal aspects about the obsessivecompulsive disorder that helped us deal with patients in practical psychotherapy. We used an integrative approach as a therapy method in order to help the patient gain control of his symptoms. Results: The psychotherapy result was an improvement of the patient’s life quality and a significant gain of control over the negative life experience.
B lymphocyte subpopulations in children after treatment of acute lymphoblastic leukemia

1Katedra i Klinika Pediatrii, Hematologii i Onkologii Dziecięcej, Zabrze, Śląski Uniwersytet Medyczny w Katowicach Kierownik Kliniki: prof. dr hab. med. Tomasz Szczepański 2Oddział Pediatryczny, Wojewódzki Szpital Specjalistyczny im. Najświętszej Maryi Panny w Częstochowie Kierownik Oddziału: lek. med. Edward Madyś 3Katedra i Klinika Pediatrii, Zabrze, Śląski Uniwersytet Medyczny w Katowicach Kierownik Kliniki: prof. dr hab. med. Katarzyna Ziora 4Katedra Mikrobiologii i Immunologii, Zabrze, Śląski Uniwersytet Medyczny w Katowicach P.o. Kierownika Katedry: dr hab. med. Zenona Czuba, prof. nadzw. SUM
Acculturation Research: Proxies as Sources of Concept Obfuscation

Proxies refer to gross global indicators of a construct that substitute for the more differentiated construct itself. Acculturation is commonly measured through the use of global indicants or proxies such as length of time in the country, age of arrival, and language spoken at home. In the present chapter, we present data from three generations of former Soviet refugees –adults, adolescents, and elderly– to explore how multiple proxies as indicants of acculturation relate to each other, to a self-report multidimensional measure of acculturation, and the extent to which all these measures predict one outcome often assessed in the acculturation literature: psychological distress. Results indicate that proxies are not interchangeable with one another or with self-report measures. In addition, they differ in their relationship to each other and to psychological distress across the three generations. These findings suggest that such proxies massively under-represent the acculturation construct and de-contextualize the experience of those who are in the process of acculturation. The present study suggests the importance of further deconstructing the acculturation concept conceptually and in terms of measurement.
Minimax Rank-$1$ Matrix Factorization

We consider the problem of recovering a rankone matrix when a perturbed subset of its entries is revealed. We propose a method based on least squares in the log-space and show its performance matches the lower bounds that we derive for this problem in the smallperturbation regime, which are related to the spectral gap of a graph representing the revealed entries. Unfortunately, we show that for larger disturbances, potentially exponentially growing errors are unavoidable for any consistent recovery method. We then propose a second algorithm relying on encoding the matrix factorization in the stationary distribution of a certain Markov chain. We show that, under the stronger assumption of known upper and lower bounds on the entries of the true matrix, this second method does not have exponential error growth for large disturbances. Both algorithms can be implemented in nearly linear time.
Water and ABA content in fully expanded leaves of cold-hardened barleys

Changes in water and ABA content during cold-hardening of plants under controlled conditions were investigated in four barley cultivars with different freezing tolerance. Plants were cultivated in a nutrient solution and had good water supply all the time. Mature leaves were sampled for analyses at the end of the darkness period. These fully-expanded leaves increased their dry matter weight, without a corresponding increase in water, during cold hardening. The increase in dry matter weight was related to improved freezing tolerance of cultivars. ABA content did not increase significantly during coldhardening. There were differences in ABA contents between cultivars, but no significant changes were observed between the hardened and control plants. Our experiments demonstrate that dry weight accumulation is important for the induction of freezing tolerance in barley during cold-hardening while an increase in endogenous ABA is not required at good water supply.