Miracle-dz/UniFAR-FTUs huggingface dataset:
Service Oriented Application System Architetcture: Business Process Management Meets Workflow Management

The research field “Services Science” deals with the opportunities and challenges of service sectors inside and outside organizations, aiming at the industrialization (global division of labor and automation) of these sectors. This goal can only be reached when the performance know-how an individual needs to execute a task can be language-critically reconstructed and managed with the aid of computers, like is the case with application software. By transforming the performance know-how into a linguistic schema that has been set up according to a human task, this “materialized know-how” –through the linguistic carrier– becomes available like a serviceable tool. Such materialization may take the form of a detailed process description through modeling languages. It can be managed –together with the IT supported processes– by business process management. The controlling of process execution can be conducted through workflow management systems. That way the process control logic is established on a technological basis.
EXPERIMENTAL RESEARCH AND CFD SIMULATION ON MICROCHANNEL EVAPORATOR HEADER TO IMPROVE HEAT EXCHANGER EFFICIENCY

Microchannel evaporator performs superior heat transfer efficiency and capacity at compact size comparing with conventional tube-fin evaporator. Design an appropriate coil header assembly is one of major tasks, which could affect the desired heat exchanger efficiency and capacity. An experimental investigation of three coil inlet header configurations, which are single, dual and distributor inlet headers, is conducted in the paper. A practical evaluation method, by means of measuring air temperature differential across coil to evaluate refrigerant distribution uniformity in coil header, is introduced. CFD models are also generated to simulate refrigerant liquid flow contours of these three inlet header configurations. Finalize the research, the distributor header configuration appears the most uniform distribution in conjunction with symmetrical flow distribution. The dual inlet header configuration also significantly improves distribution uniformness and symmetry comparing with the single inlet header configuration.
Strategic cost management.

The second major risk is that an IT organization that is not agile will also likely be very inefficient and this will in turn limit the extent to which the business can launch initiatives. The inefficient IT organization will tend to burden up the cost structure of the business, increasing the pressures on cash flows and forcing the business to obtain additional capital to finance its business-level initiatives or to reduce the number or scale of initiatives, thereby limiting value creation.
O interpretacji etnicznej wczesnośredniowiecznych pochówków elitarnych. Skandynawowie w państwie pierwszych Piastów i na Pomorzu

This paper discusses two groups of early medieval burials associated with the elites of the Piast state and Pomeranian duchies: chamber graves and graves with stone constructions. Features associated with the first group appear in the Piast state and in Eastern Pomerania in the fourth quarter of the 10th century, while in Western Pomerania in the second half of the 11th and in the 12th centuries. Some, especially dating from the 10th and 11th centuries, were interpreted by Polish archaeologists as material traces of the migration of Scandinavians. A similar interpretation was also presented with reference to the graves with stone constructions, known mainly from the areas of Mazovia, Podlasie and Central Poland, where they appeared from the turn of the 10th and 11th centuries, but mainly from the second quarter of the 11th century. Previously, these graves were considered typical of the ethnic Polish (or particularly Mazovian) population. This article is an attempt to critically review these interpretations in the light of an analysis of burials and burial sites, primarily with respect to modern theories of ethnicity and archaeology as a cognitive discipline in the field of ethnic studies. The analysis presented tends to consider at least some of these graves as burials of local elites, and challenges or questions the possibility of their identification as burials of Scandinavians in the current state of research.
FINAL PROGRAM REPORT FOR DEVELOPMENT OF RESONANT TUNNELING DIODE CIRCUITS USING EPITAXIAL LIFTOFF

The combination of resonant tunneling diodes (RTDs) and complementary metal-oxidesemiconductor (CMOS) silicon circuitry can offer substantial improvement in speed, power dissipation, and circuit complexity over CMOS-only circuits. We demonstrate the first integrated resonant tunneling CMOS circuit, a clocked one-bit comparator with a device count of 6, compared with 21 in a comparable all-CMOS design. A hybrid integration process is developed for InP-based RTDs which are transferred and bonded to CMOS chips. The prototype comparator shows sensitivity in excess oflO VIA, and achieves error-free performance in functionality testing. An optimized integration process, under development, can yield highspeed, low-power circuits by lowering the high parasitic capacitance associated with the prototype circuit.
Stable optical filter using porous silicon technology

A stable multilayer IR optical filter is designed based on the porous silicon technology. The filter stability is achieved based on the mechanical properties of porous silicon that are used to tailor the stresses inside the mutilayer structure. The filter, working at the wavelength of 1.55 µm, have been designed to be matched with spot sizes of 7 µm and 8.5 µm which makes it compatible with single mode fiber used in optical communications
Augmented p‐rep designs

Early generation variety trials are very important in plant and tree breeding programs. Typically many entries are tested, often with very little resources available. Unreplicated trials using control plots are popular and it is common to repeat the trials at a number of locations. An alternative is to use p‐rep designs, where a proportion of the test entries are replicated at each location; this can obviate the need for control plots. α‐Designs are commonly used for replicated variety trials and we show how these can be adapted to produce efficient p‐rep designs.
A phase 2 study of bortezomib in relapsed, refractory myeloma.

BACKGROUND Bortezomib, a boronic acid dipeptide, is a novel proteasome inhibitor that has been shown in preclinical and phase 1 studies to have antimyeloma activity. METHODS In this multicenter, open-label, nonrandomized, phase 2 trial, we enrolled 202 patients with relapsed myeloma that was refractory to the therapy they had received most recently. Patients received 1.3 mg of bortezomib per square meter of body-surface area twice weekly for 2 weeks, followed by 1 week without treatment, for up to eight cycles (24 weeks). In patients with a suboptimal response, oral dexamethasone (20 mg daily, on the day of and the day after bortezomib administration) was added to the regimen. The response was evaluated according to the criteria of the European Group for Blood and Marrow Transplantation and confirmed by an independent review committee. RESULTS Of 193 patients who could be evaluated, 92 percent had been treated with three or more of the major classes of agents for myeloma, and in 91 percent, the myeloma was refractory to the therapy received most recently. The rate of response to bortezomib was 35 percent, and those with a response included 7 patients in whom myeloma protein became undetectable and 12 in whom myeloma protein was detectable only by immunofixation. The median overall survival was 16 months, with a median duration of response of 12 months. Grade 3 adverse events included thrombocytopenia (in 28 percent of patients), fatigue (in 12 percent), peripheral neuropathy (in 12 percent), and neutropenia (in 11 percent). Grade 4 events occurred in 14 percent of patients. CONCLUSIONS Bortezomib, a member of a new class of anticancer drugs, is active in patients with relapsed multiple myeloma that is refractory to conventional chemotherapy.
Utilisation des contraintes (m, k)-firm pour la gestion de la QdS dans les SGBD temps réel

RESUME. Dans les systemes temps reel manipulant des tâches periodiques, des travaux introduisant la notion de contraintes (m,k)-firm ont ete effectues. Ces contraintes permettent de relaxer les contraintes temps reel des tâches en autorisant que certaines invocations d’une tâche soient perdues. D’un autre cote, dans les SGBD temps reel, certaines transactions periodiques permettent, de rafraichir des donnees temporelles de la base a partir de capteurs. Ces transactions sont appelees "transactions de mise a jour" par opposition aux "transactions utilisateur" qui manipulent des donnees temporelles ou non. Dans ce papier, nous proposons une adaptation des contraintes (m,k)-firm aux transactions de mise a jour dans les SGBD temps reel. En se basant sur l’exploitation d’une architecture avec controle par retroaction et sur les contraintes temps reel (m,k)-firm, nous proposons d’augmenter cette architecture afin de filtrer l’arrivee des transactions de mise a jour en tenant compte des variations de la charge du systeme.
A clinical study of competency in child psychiatric inpatients.

A 17-item competency questionnaire, modified for use with children and adolescents (CQ-ChP), was used to evaluate competency to consent to hospitalization and treatment in child psychiatric inpatients. A total of 25 consecutive English-speaking psychiatric child inpatient admissions were studied. Demographic data were statistically analyzed using chi 2, and there were no significant statistical differences between the competent and incompetent groups (using CQ-ChP scores and cut-offs). The various demographic/clinical variables and scores on the questionnaire were also statistically evaluated using chi 2. The only statistical significance was the association between reading level and competency with a value of p < . 05. Therefore, by achieving a reading level at the fifth-grade standard, subjects were found to be competent as measured by the CQ-ChP.
The association between dental anxiety and oral health-related quality of life in Britain.

OBJECTIVE The aim of this study was to identify associations between level of dental anxiety and the impact of oral health on quality of life (OHQOL) in Britain, controlling for sociodemographic and oral health status (self-reported) factors. METHODS The basic research design included a cross-sectional study involving a random probability sample of 3000 UK residents. The outcome measures were: levels of dental anxiety, which were measured on the Corah Dental Anxiety Scale (DAS), and the impact of OHQOL, which was assessed using UK oral health-related quality of life instrument (OHQoL-UK (W)). RESULTS DAS was correlated with OHQoL-UK (W) scores (P < 0.01). Having controlled for sociodemographic factors (age, gender and social class) and oral health status factors (self-reported number of teeth possessed and denture status), known confounding factors associated with OHQOL, those with high levels of dental anxiety (DAS > or = 15) were approximately two times as likely to be among those experiencing the poorest OHQOL (below the population median OHQoL-UK (W) score) in Britain (P < 0.001; OR = 1.93; 95% CI 1.41, 2.65). CONCLUSION Dental anxiety is associated with the impact oral health has on life quality. Those experiencing high levels of dental anxiety are among those with the poorest oral health-related quality of life in Britain.
Early Health Related Behaviours and Their Impact on Later Life Chances: Evidence from the Us (Out (Publ. In Health Economics, 7(5), 1998)

This paper uses evidence from the US to examine the impact of adolescent illegal consumption and violent behaviour on later life chances. Specifically, we look at the effect of such behaviour by young men in late adolescence on productivity and household formation 10 years on. We find that alcohol and soft drug consumption have no harmful effects on economic prospects in later life. In contrast, hard drug consumption and violent behaviour in adolescence are both associated with lower productivity even by the time the individuals are in their late twenties. These effects are substantial and affect earnings levels and earnings growth. These results are robust to the inclusion of a rich set of additional controls measuring aspects of the individuals' backgrounds. However, we find no evidence of any of these behaviours significantly affecting household formation.
Privacy-Preserving Collection and Retrieval of Medical Wearables Data

In recent years we have seen a rise in the amount of fitness tracking and self monitoring devices. These devices which often work in conjunction with a smartphone are becoming more accurate and are becoming widely adopted. This trend goes hand in hand with Electronic Health Care (e-health): the shift of health care to the digital domain. E-health would allow patients to measure their medical condition at home, allowing a diagnosis to be made based on measurements taken over a longer period of time, while reducing the work performed by a doctor. Measurements are tored in the cloud, simplifying the way in which they can be shared with healthcare providers and possibly research nstitutions. Modernizing healthcare this way should give the patient more insight and control over his/her healthcare and medical data. Furthermore the amount of visits required to the hospital can be reduced, an endeavor which can be demanding for many less fit for elderly individuals. However, handling medical data this way causes concern for privacy. Often the data handled by these devices is very sensitive and could easily be used to identify the user and monitor many of their behaviours. In order to achieve privacy there are several approaches. One way is to enforce involved parties through legislation to use the data for specific purposes only. However, this relies on the party being semi-trusted and does not guarantee safety in case of a data-breach. In this work the way in which the integration of wearables into the medical domain is currently taking place and how privacy and security is handled will be explored. Furthermore we will show the current state of research regarding improving this security.
TERF 1 – telomeric repeat-binding factor 1 ; TRF 2 or TERF 2 – telomeric repeat-binding factor 2 Mini review TELOMERASE AND ITS EXTRACURRICULAR ACTIVITIES

The classical activity of telomerase is to synthesize telomeric repeats and thus maintain telomere length, which in turn ensures chromosome stability and cellular proliferation. However, there is growing evidence that implicates telomerase in many other functions that are independent of TERC being used as its template. Telomerase has an RNA-dependent RNA polymerase (RdRP) activity in the mitochondria. Other than viral RdRPs, it is the only RNAdependent RNA polymerase that has been identified in mammals. It also plays a role in the Wnt signaling pathway by acting as a transcriptional modulator. Telomerase acts as a reverse transcriptase independent of its core subunit, TERC. Studies indicate that telomerase is also involved in apoptosis and DNA repair.
Brain mechanisms of social cognition.

Darwin was the first to put forward an evolutionary account of expression. Since his day, comparative studies of living primates have taught us that in the course of primate evolution there has been a shift from nocturnal to diurnal activity. This shift has been accompanied by (i) the development of complex social groups, (ii) the elaboration of a facial muscular architecture whose function is expression, and (iii) a relative expansion of visual as compared with olfactory brain regions (Allman, 1982). The implication of these phylogenetic trends is that primates have developed a capacity not only for sending visual social signals, as noted by Darwin, but also for interpreting and responding to them. Indeed, primatologists have provided us with a wealth of information about non-human primates’ social cognition, such as their ability to understand complex kin relationships, dominance hierarchies, and even the mental states of others (Premack and Woodruff, 1978; Cheney, Seyfarth and Smuts, 1986; Byrne and Whiten, 1988). The latter ability, the construction of a ’theory of other minds’, seems to have developed progressively over the course of primate evolution, for it appears to be weak at best in monkeys (Cheney and Seyfarth, 1990), stronger-possibly-in apes (Premack 1988; Whiten and Byrne, 1989) and developed to its Machiavellian peak in man. Such a progression suggests that, in the common ancestor of apes and man, there emerged an advantage for cognitive operations which could predict others’ behavior, and that these operations have ’taken off in hominids (Humphrey, 1983). The development of social cognitive skills in children, more particularly the ability to ’mentalize’, has received considerable research attention (Astington, Harris and Olson, 1988; Frith, Morton and Leslie, 1991; Leslie, 1987). Although the central cognitive deficit of autism has been proposed to be a failure to represent mental states such as belief, autistic individuals display a profile of behavioral abnormalities which is incompletely explained by this model (Baron-Cohen, 1988). It therefore seems wise to follow the course indicated by Frith, namely, to use the term ’cognitive’ in a broad sense which includes affective factors. For example, autistic children fail to engage in joint attention with adults regarding interesting toys (Mundy et al., 1986) or to use social referencing in ambiguous situations (Sigman et al., 1992). These defects can be seen as reflecting an inability to conceive of another as an ’agent of contemplation’; or, they can be seen as an inability to conceive of sharing an evaluative stance. The conflict between accounts invoking a more narrowly defined cognitive defect in autism, and those invoking primarily affective defects probably reflects
BRCA1-Ku80 Protein Interaction Enhances End-joining Fidelity of Chromosomal Double-strand Breaks in the G1 Phase of the Cell Cycle*

Background: Quality control of DNA double-strand break repair is poorly understood. Results: BRCA1 enhances the fidelity of NHEJ repair and prevents mutagenic deletional end-joining through interaction with canonical NHEJ machinery during G1. Conclusion: BRCA1 ensures high fidelity repair of NHEJ and thus prevents deletional end-joining of chromosomal DSBs during G1. Significance: BRCA1 not only promotes homologous recombination in G2/M phase but also facilitates fidelity of NHEJ repair during G1. Quality control of DNA double-strand break (DSB) repair is vital in preventing mutagenesis. Non-homologous end-joining (NHEJ), a repair process predominant in the G1 phase of the cell cycle, rejoins DSBs either accurately or with errors, but the mechanisms controlling its fidelity are poorly understood. Here we show that BRCA1, a tumor suppressor, enhances the fidelity of NHEJ-mediated DSB repair and prevents mutagenic deletional end-joining through interaction with canonical NHEJ machinery during G1. BRCA1 binds and stabilizes Ku80 at DSBs through its N-terminal region, promotes precise DSB rejoining, and increases cellular resistance to radiation-induced DNA damage in a G1 phase-specific manner. These results suggest that BRCA1, as a central player in genome integrity maintenance, ensures high fidelity repair of DSBs by not only promoting homologous recombination repair in G2/M phase but also facilitating fidelity of Ku80-dependent NHEJ repair, thus preventing deletional end-joining of chromosomal DSBs during G1.
Red wine consumption inhibits LDL oxidation and aggregation in humans and in atherosclerotic mice

Consumption of phenolic flavonoids in the diet was shown to be inversely associated with morbidity and mortality from coronary heart disease [1–4]. Different classes of flavonoids are present in different fruits, vegetables, and in beverages such as tea and wine. Flavonoids may prevent coronary artery disease by reducing platelet aggregation, by reducing damage from ischemia and reperfusion, or by inhibiting LDL oxidation. Polyphenol constituents in olive oil were shown to contribute to the inhibition of LDL oxidation [5,6]. Crude extract of licorice, derived from the roots of the Asian plant Glycyrrhiza glabra, which is also a nutrient rich in polyphenols (mainly glabridin), was recently shown to protect LDL against lipid peroxidation both in vivo and in vitro [7]. Consumption of black or green tea, which are rich in other subclasses of polyphenols was also shown to be associated with an increase in the plasma antioxidant potential [8]. The antioxidant activity of the flavonoids is related to their chemical structure [9,10], and this may account for the differences in the antioxidative capacity of different nutrients.
Protein turnover during puberty in normal children.

To investigate whether insulin resistance of puberty involves protein metabolism, we compared whole body leucine kinetics in 20 prepubertal Tanner I (TI), and 21 pubertal Tanner II-IV (TII-IV) healthy children. Leucine flux (LRa), oxidation (LOX), and nonoxidative disposal (NOXLD) were measured during primed constant infusion of [1-13C]leucine at baseline and during a stepwise hyperinsulinemic (10 and 40 mU.m-2.min-1)euglycemic clamp in combination with indirect calorimetry. At baseline LRa and LOX were lower in TII-IV vs. TI [LRa: 3.59 +/- 0.17 vs. 4.05 +/- 0.18 mumol.min-1.kg-1 fat-free mass (FFM), P = 0.036; LOX: 0.45 +/- 0.03 vs. 0.59 +/- 0.04 mumol.min-1. FFM-1, P = 0.005], but NOXLD was similar. Insulin-like growth factor I (IGF-I) levels correlated inversely with LRa, NOXLD, and LOX. Energy expenditure correlated positively with LRa, LOX, and NOXLD. During the clamp absolute and percent suppression in LRa were significantly lower in TII-IV than TI. In conclusion, 1) proteolysis and protein oxidation are lower during puberty compared with prepuberty, whereas protein synthesis is unchanged; 2) insulin action in inhibiting proteolysis is decreased during puberty; and 3) increased pubertal IGF-I levels may play a role in decreased protein degradation.
CDMCR: multi-level fault-tolerant system for distributed applications in cloud

Cloud provides users with a new model of utilizing the computing infrastructure with the ability to perform parallel and distributed computations using elastic virtual cluster. However, the multi-level and complex features make cloud computing system more prone to failure. In this paper, we present a multi-level fault-tolerant system for distributed applications in cloud named Distributed-application oriented Multi-level Checkpoint/Restart for Cloud CDMCR. The CDMCR system backups the complete state of applications periodically with a snapshot-based distributed checkpointing protocol, including file system state. Thus, we cannot only recover processes but also rollback data. A multi-level recovery strategy is proposed, which includes process-level recovery, virtual machine recreation, and host rescheduling, enabling comprehensive and efficient fault tolerance for different components in cloud. We deploy CDMCR as PaaS, so that users can be liberated from node management and system configuration and get access to fault-tolerant service conveniently. We have implemented this system based on the Xen virtualization platform and the OpenNebula cloud platform. Experiments on the prototype demonstrate the correctness of the system. Analysis shows that CDMCR does not cause message loss or data loss, and the backup time remains nearly constant as the number of nodes increases on virtual cluster. Copyright © 2015 John Wiley & Sons, Ltd.