Miracle-dz/UniFAR-FTUs huggingface dataset:
Alternative Marketing Strategy for Egyptian Hotels after Political Crises: Exploratory Study

Unlike natural disasters, political crises can continue to impact any tourism destination image for months if not years. Literatures discussed the impacts of terrorism and political crises on the tourism industry and argued that terrorism and political instability intimidate tourists and the tourism industry considerably. And as Egypt suffer from a Continuous political crisis began with the Egyptian Revolution of 2011, the hotel industry in Egypt suffered a huge decline in its business in terms of occupancy rates and hotel revenues from 2011 to 2015. This study comes to explore the marketing strategies that can be used by Egyptian hotels during political crises. It used a Delphi technique to collect and unify the hotel marketing experts' opinions. 30 hotel marketing experts participated in this Delphi technique study, which include three rounds using a special structured questionnaire form for each round. Results recommended specific marketing strategies for Egyptian hotels to recover of political crises; these strategies describe the marketing decisions related to target market, and all the elements of the hotel marketing mix. Keywords : Hotel, Marketing Strategies, 7Ps, Political crises, Egypt
Analysis of Gene Expression in Streptococcus Mutans in Biofilms in Vitro

The purpose of this study was to develop methods for the consistent production of biofilms of S. mutans containing reporter gene fusions, and to examine the expression of genes involved in sucrose metabolism in adherent populations of this organism. Three strains of S. mutans harboring reporter gene fusions to the gene promoter regions of the gtfBC genes, ftf, and scrA were grown in a Rototorque biofilm fermenter in a tryptone-yeast extract-sucrose medium. Quasi-steady-state levels of reporter gene activity were measured after the biofilms were grown for either 48 hrs or 7 days. Also, induction of gene expression by the addition of sucrose to biofilm cells was monitored. Reporter gene activity was measurable from all gene fusion strains. This study (i) establishes the feasibility of doing detailed molecular and physiologic studies on immobilized populations of S. mutans, (ii) demonstrates that the polysaccharide synthesis machinery of S. mutans is differentially expressed in biofilms, and (iii) opens the way for a more detailed analysis of the environmental signals and signal transduction pathways governing the regulation of gene expression by S. mutans cells that are immobilized on a solid surface.
Moving beyond (non-)compliance: the customization of European Union policies in 27 countries

ABSTRACT Europeanization research often neglects that the implementation of European Union (EU) policy results in diverse national outcomes, even if member states comply with EU law. Such fine-grained Europeanization patterns have been explored as ‘gold-plating’ and ‘customization’. This contribution builds and expands on this research to propose a general conceptualization and measurement of customization as the changes that provisions of EU Directives undergo in their regulatory density and restrictiveness during legal transposition. Using unique data on the customization of EU directive provisions from two policy areas in 27 countries, our empirical analysis reveals distinct changes in density and restrictiveness, pronounced policy-specific and state-level customization patterns. The findings illustrate how national customization strategies often follow specific EU regulatory logics in different integration contexts. We outline implications for future research on the causes and consequences of the inherent diversity of EU implementation regarding dimensions of customization, issues of legitimacy and effectiveness.
Associations between Birth Health, Maternal Employment, and Child Care Arrangement among a Community Sample of Mothers with Young Children

Although a large body of literature exists on how different types of child care arrangements affect a child's subsequent health and sociocognitive development, little is known about the relationship between birth health and subsequent decisions regarding type of nonparental child care as well as how this relationship might be influenced by maternal employment. This study used data from the Los Angeles Families and Neighborhoods Survey (L.A.FANS). Mothers of 864 children (ages 0–5) provided information regarding birth weight, maternal evaluation of a child's birth health, child's current health, maternal employment, type of child care arrangement chosen, and a variety of socioeconomic variables. Child care options included parental care, relative care, nonrelative care, and daycare center. Multivariate analyses found that birth weight and subjective rating of birth health had similar effects on child care arrangement. After controlling for a child's age and current health condition, multinomial logit analyses found that mothers with children with poorer birth health are more likely to use nonrelative and daycare centers than parental care when compared to mothers with children with better birth health. The magnitude of these relationships diminished when adjusting for maternal employment. Working mothers were significantly more likely to use nonparental child care than nonemployed mothers. Results suggest that a child's health early in life is significantly but indirectly related to subsequent decisions regarding child care arrangements, and this association is influenced by maternal employment. Development of social policy aimed at improving child care service should take maternal and family backgrounds into consideration.
Trends in the Use of Regional Anesthesia: Neuraxial and Peripheral Nerve Blocks

Background A growing body of evidence indicates that the use of regional anesthesia offers advantages over general anesthesia, not only in terms of reducing complications but also regarding resource utilization and patient satisfaction. Because of the paucity of data on the nationwide adoption of regional anesthesia techniques, we aimed to elucidate trends in the use of neuraxial anesthesia (NA) and peripheral nerve blocks (PNBs) in orthopedic surgeries. Methods We extracted data from N = 959,257 (Premier Perspective database; 2006–2013) total hip and knee arthroplasties (THA, TKA) and assessed NA/PNB use by a 2-year period, stratified by demographics and hospital factors. Cochran-Armitage trend tests assessed significance of trends. Results Comparing 2006–2007 with 2012–2013, NA utilization decreased slightly from 21.7% to 19.7% for THA patients; this was 24.7% to 21.3% for TKA patients (with the main drop between 2012 and 2013). Conversely, PNB utilization increased from 6.5% to 8.7% for THA patients and 10.3% to 20.4% for TKA patients (all P < 0.001). These general trends did not change when stratified by patient demographics, whereas stratification by hospital factors did show differences: the highest NA utilization was seen in rural, nonteaching, and small hospitals, whereas the highest PNB utilization was seen in large and teaching hospitals. Conclusions Our findings provide important insight into the dynamics of the adoption of regional anesthetic techniques. Whereas PNB utilization is significantly increasing, overall, NA and PNBs are performed in the minority of cases. With accumulating evidence in favor of regional anesthesia, promoting the use of NA and a further increase in PNB utilization could have far-reaching medical and economic implications.
The European Council as a crisis driven ‘gouvernement économique’

Introduction: High on the agenda of the European Council as the key institution within the EU’s architecture are issues of economic governance. The various policies that form part of economic governance – monetary, fiscal, and other economic and social policies – are usually regarded as the most important or at least the most often discussed areas of the European Council’s policy-making (see for example Van Rompuy 2010). Following their problem-solving instinct, since the 1970s, the Union’s political leaders have regularly and extensively used the European Council to cope with economic challenges that the European states were faced with. The performance and profile of the European Council in this area is difficult to capture. The term ’economic governance’, used by the European Council itself (for example March 2011) , is only useful for a first general orientation as this policy field is characterised by a confusing array of institutions, processes, mechanisms and instruments (Begg 2011: 337-339). To consider the European Council’s performance in the economic realm, this paper takes a closer look at the institution’s activities as constitutional architect, at its leadership-role as crisis manager and at its institutional position in the centre of the multi-pillar architecture.
Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression

Keratin polypeptides 8 and 18 (K8/18) are the major intermediate filament proteins of simple-type epithelia. K18 Ser-33 phosphorylation regulates its binding to 14-3-3 proteins during mitosis. We studied the significance of keratin binding to 14-3-3 in transgenic mice that overexpress wild-type or Ser-33→Ala (S33A) K18. In S33A but not wild-type K18-overexpressing mice, pancreatic acinar cell keratin filaments retracted from the basal nuclear region and became apically concentrated. In contrast, K18 S33A had a minimal effect on hepatocyte keratin filament organization. Partial hepatectomy of K18-S33A-overexpressing mice did not affect liver regeneration but caused limited mitotic arrest, accumulation of abnormal mitotic figures, dramatic fragmentation of hepatocyte keratin filaments, with retention of a speckled 14-3-3ζ mitotic cell nuclear-staining pattern that usually becomes diffuse during mitosis. Hence, K18 Ser-33 phosphorylation regulates keratin filament organization in simple-type epithelia in vivo. Keratin binding to 14-3-3 may partially modulate hepatocyte mitotic progression, in association with nuclear redistribution of 14-3-3 proteins during mitosis.
iwantgreatcare: problems

There are numerous problems with the concept behind iwantgreatcare.org, andmany have already been highlighted by Cohen’s blog. With regard to the website, it is claimed that there are measures in place to identify abuse such as multiple posts by a single person. However, what is to stop a grudge bearing patient or an overly tempted doctor from logging in as different users and swaying the overall reviews to one side? As a public health professor frommy epidemiology module would say, the results and reviews for each doctor will be greatly biased in that only patients who are proficient in using the internet will be able to contribute. Perhaps the computer literate population has different expectations of a doctor than people not trained in information technology—notably, elderly patients. Although 96% of the reviews on the website were positive in the first week, I still believe that the website will attract a greater number of negative reviews in the long run. I certainly have a tendency to make greater effort when criticising something rather than commending it (as evidenced by this letter), and I believe the patient population contributing to the reviews will have similar priorities. Logically this may lead doctors to ask their patients to post good reviews for them—in effect, marketing their skills to the wider (internet) patient population. I think I prefer the old, modest practitioner.
Pulmonary serotonin 5-HT3-sensitive afferent fibers modulate renal sympathetic nerve activity in rats.

Cardiopulmonary reflexes with vagal afferents may control volume homeostasis by influencing renal nerve activity. Such reflexes can be stimulated mechanically and chemically, e.g., by serotonin 5-HT). We have demonstrated that stimulation of epicardial 5-HT3 receptors inhibits renal sympathetic nerve activity (RSNA) by a cardiorenal reflex. We now tested the hypothesis that pulmonary 5-HT3-sensitive vagal afferent fibers participate in the control of renal nerve activity. Two sets of experiments were performed. First, the responses of multifiber RSNA, heart rate (HR), and blood pressure (BP) to the 5-HT3-receptor agonist phenylbiguanide (PBG; 10 microg iv) were recorded in the presence of intact pulmonary afferents. Abdominal afferents were removed by subdiaphragmatic vagotomy. Cardiac afferents were blocked by intrapericardial injection of 10% procaine. Second, the responses of 25 single vagal pulmonary afferent C fibers to PBG were assessed. PBG decreased BP, HR, and RSNA (-90 +/- 8%). When cardiac afferents were blocked by procaine, BP and HR failed to decrease in response to PBG; however, the RSNA decrease was still -48 +/- 8%. Single fibers generally responded to PBG by a slight increase in firing rate. A distinct subset of fibers (5 of 25) showed an activity increase of >15 Hz that preceded changes in BP and HR. The decreased RSNA in the absence of cardiac and abdominal vagal afferents and the strong response of 20% of pulmonary single fibers to intravenous PBG suggest that pulmonary fibers play a role in a 5-HT3 serotenergic reflex. Thus pulmonary serotonin could influence the neural control of renal function.
Accumulation of periplasmic enterobactin impairs the growth and morphology of Escherichia coli tolC mutants

TolC is the outer membrane component of tripartite efflux pumps, which expel proteins, toxins and antimicrobial agents from Gram‐negative bacteria. Escherichia coli tolC mutants grow well and are slightly elongated in rich media but grow less well than wild‐type cells in minimal media. These phenotypes have no physiological explanation as yet. Here, we find that tolC mutants have highly aberrant shapes when grown in M9‐glucose medium but that adding iron restores wild‐type morphology. When starved for iron, E. coli tolC mutants synthesize but cannot secrete the siderophore enterobactin, which collects in the periplasm. tolC mutants unable to synthesize enterobactin display no growth or morphological defects, and adding exogenous enterobactin recreates these aberrations, implicating this compound as the causative agent. Cells unable to import enterobactin across the outer membrane grow normally, whereas cells that import enterobactin only to the periplasm become morphologically aberrant. Thus, tolC mutants grown in low iron conditions accumulate periplasmic enterobactin, which impairs bacterial morphology, possibly by sequestering iron and inhibiting an iron‐dependent reaction involved in cell division or peptidoglycan synthesis. The results also highlight the need to supply sufficient iron when studying TolC‐directed export or efflux, to eliminate extraneous physiological effects.
Effect of surface fluorination on space charge behavior in multilayered polyimide films

In recent years, the multilayered polyimide films have been widely used in flexible Print-Circuit Board in order to reduce the thickness of the combination of the flexible Print-Circuit Board. The existence of space charge as a main reason for dielectric breakdown, has a great effect on breakdown characteristic. So it is important to study the space charge characteristics of the multilayered polyimide films. Fluorination can change the chemical component in surface layer of polymers and therefore can influence the charge injection from electrodes and affect the electrical properties of the surface layer. This paper presents a study aimed at clarifying the effect of fluorination on space charge behavior in multilayered polyimide films. Samples were fluorinated in a laboratory vessel at 328 K (55 °C) using a F2/N2 mixture with 20% F2 by volume and 0.05 MPa (500 mbar) for respectively 15, 30, 45 and 60 minutes. The surface chemical compositions of the films were characterized by attenuated total reflection infrared analysis. The space charge distributions in multilayered polyimide films were measured by using the pulsed electroacoustic (PEA) method. Obtained results showed that the space charge distribution of multilayered film stacking with five fluorinated samples was quite different from that of multilayered film stacking with five untreated samples. It is also suggested that the fluorination can significantly suppress the injection of space charge.
A Family's Coming to Terms with Alzheimer's Disease

Findings of a qualitative analysis of several members of a family in which one member has Alzheimer s Disease (AD) support the notion that differences in how eachfamily member defines and makes meaning of the situation have consequences for the family as a unit. Ten in-depth individual and dyadic interviews of five available fanily members were conducted during a period of 18 months. Data support the finding that each member of the family experienced a similarprocess of coming to terms with changes in theperson who has AD. Thisprocess consisted of three stages: identifying how the person with AD was the same as he was before, as well as how he was different, prior to disease onset; redefining the identity of the person with AD; and rewriting one's relationship with the person with AD. This study supports both Knajl's and Deatrick's concept of family management and Patterson's concept offamily meaning.
Finite-time H∞ control for extended Markovian jump systems with partially known transition probabilities

This note addresses the problem of finite-time H∞ control for a class of extended Markovian jump systems. The stochastic process of given system is described by a Markovian chain, and the knowledge of transition jump rates is inaccurate. In this case, the theoretical results on finite-time boundedness, H∞ finite-time boundedness and finite-time H∞ state feedback stabilization, are developed, respectively. Then, the purpose is to design a finite-time H∞ state feedback controller so that the corresponding closed-loop system result to be finite-time boundedness. It is shown that the corresponding existence conditions are presented via a set of strict linear matrix inequalities. Finally, a numerical example is given to demonstrate the effectiveness of the proposed theoretical results.
Catheter-based transendocardial gene delivery for therapeutic myocardial angiogenesis

it is unknown which is the most effective and safest delivery strategy for therapeutic myocardial angiogenesis. The enhancing effect of direct intramyocardial injection of angiogenic factors using either open-chest or catheter-based approaches on collateral function has been reported to occur in experimental models and among patients. This report reviews the rationale and current experience of using a catheter-based approach as a promising platform for proangiogenic intramyocardial gene delivery strategy. (Int J Cardiovasc Intervent 2000; 3: 67–70)
Smoking behavior among third year dental students in Latin American countries: prevalence, perceptions, and risk factors.

Objective: To examine the association between tobacco-related risk factors and smoking among third-year dental students in Latin American countries. Materials and methods: Logistic regression models were used to analyze Global Health Professions Student Survey (GHPSS) data. Results: Of 5 605 respondents, 33% smoked and 45% had been exposed to secondhand smoke during the previous month, 34% smoked in school buildings during the past year, and 85% had never received formal training in smoking cessation. Smoking was significantly associated with male sex; Bolivian, Chilean, or Mexican nationality; exposure to secondhand smoke; lacking self-perception of being a "role model" for patients; and not believing that health professionals who smoke are less likely to advise patients to quit smoking. Conclusions: All dental schools should encourage tobacco-free policies and offer cessation services. Cessation training must be incorporated into dental curricula to include dental professionals in the battle against the tobacco epidemic.
Chromosomal microarray testing influences medical management

Purpose: Chromosomal microarray (CMA) testing provides the highest diagnostic yield for clinical testing of patients with developmental delay (DD), intellectual disability (ID), multiple congenital anomalies (MCA), and autism spectrum disorders (ASD). Despite improved diagnostic yield and studies to support cost-effectiveness, concerns regarding the cost and reimbursement for CMA have been raised because it is perceived that CMA results do not influence medical management.Methods: We conducted a retrospective chart review of CMA testing performed during a 12-month period on patients with DD/ID, ASD, and congenital anomalies to determine the proportion of cases where abnormal CMA results impacted recommendations for clinical action.Results: Among 1792 patients, 13.1% had clinically relevant results, either abnormal (n = 131; 7.3%) or variants of possible significance (VPS; n = 104; 5.8%). Abnormal variants generated a higher rate of recommendation for clinical action (54%) compared with VPS (34%; Fisher exact test, P = 0.01). CMA results influenced medical care by precipitating medical referrals, diagnostic imaging, or specific laboratory testing.Conclusions: For all test indications, CMA results influenced medical management in a majority of patients with abnormal variants and a substantial proportion of those with VPS. These results support the use of CMA as a clinical diagnostic test that influences medical management for this patient population.
PREVALENCE AND DISTRIBUTION OF PSEUDOGYMNOASCUS DESTRUCTANS IN MICHIGAN BATS SUBMITTED FOR RABIES SURVEILLANCE

Abstract Since 2006, bat populations in North America have suffered devastating mortality from an emerging disease known as white-nose syndrome (WNS). The causal agent of WNS is the fungus Pseudogymnoascus destructans. In April 2014, WNS was discovered in little brown bats (Myotis lucifugus) in Michigan, US, and has since been documented in 12 counties. Because current surveillance for WNS focuses primarily on mine-hibernating species in winter, it is subject to geographic, species, and seasonal bias. To investigate species affected and potential associations of gender, seasonal life cycle, and region with P. destructans prevalence, 1,040 rabies-negative bats were sampled from May 2014 to May 2015 from animals submitted as part of statewide rabies surveillance. The vast majority (96%) of the sample population consisted of big brown bats (Eptesicus fuscus), a noncavernicolous species. Two methods were used to detect P. destructans: fluorescence of the muzzle, wing, and tail membranes under ultraviolet light and PCR targeting genomic DNA on wing samples. Only five bats (0.5%), all M. lucifugus, were confirmed positive after nucleic acid sequencing of PCR amplicons. No other species were infected. All infected bats were collected from April to May, coinciding with their emergence from hibernation. As P. destructans and WNS spread westward, novel surveillance streams may provide a useful tool for wildlife management agencies seeking to detect the fungus where winter hibernacula such as caves and mines are absent or otherwise inaccessible.