Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection and Control of Abnormal Behavior in Controlled Network System

This paper introduced the concept, the classification and the control principal of network behaviors,discussed the concept, composition and structure, and the behavior control of the controlled network system, then proposed the detection and control model of abnormal behavior in controlled network system. This model of abnormal behavior detection was designed by combining misuse and intrusion detection mechanism, and is the specific application of the research on network behavior and controlled theory, and it controls the network behaviors especially abnormal behaviors. The theory is the basis for establishing the dynamic controllable network security system. With the development of network and information technologies, it seems that the network size, the diversity of network equipment and the complexity of network topology structure are constantlyincreasing, which leads to the probability of security problems emergeis also increasing. However, the traditional network security measures cannot meet the needs of the actual complex network activities, the existing information network has an urgent need to propose a new theory or new method which can reflect the overall network security and behavior control states. As a kind of efficient, scientific and reasonable network security theory, the controlled network is the integration of existing network security technologies and measures, and the aim of it is to construct a controlled network and solve the network security problems(1).
Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression

Synaptic cell adhesion molecules (SynCAMs) are single transmembrane proteins that belong to the immunoglobulin superfamily of cell adhesion molecules. In the present study, a decrease in SynCAM levels in ovarian tumor tissues compared with normal tissues is reported; the downregulation was accompanied by the grade malignancy. The observations suggested that SynCAM may be essential for important novel functions in ovarian cancer. Further experiments showed that low SynCAM expression inhibited membrane palmitoylated protein 6 (MPP6) expression, a member of the palmitoylated membrane protein subfamily of peripheral membrane-associated guanylate kinases. In addition, low levels of MPP6 in ovarian tumor tissues correlated with shorter patient survival. A SynCAM-regulated pathway may provide molecular targets for the treatment of ovarian cancer and novel biomarkers to be used in clinical diagnosis.
Unconstrained receding horizon control of nonlinear systems

It is well known that unconstrained infinite horizon optimal control may be used to construct a stabilizing controller for a nonlinear system. In this paper, we show that similar stabilization results may be achieved using unconstrained finite horizon optimal control. The key idea is to approximate the tail of the infinite horizon cost-to-go using, as terminal cost, an appropriate control Lyapunov function (CLF). We provide a complete analysis of the stability and region of attraction/operation properties of receding horizon control strategies that utilize finite horizon approximations in the proposed class. It is shown that the guaranteed region of operation contains that of the CLF controller and may be made as large as desired by increasing the optimization horizon (restricted, of course, to the infinite horizon domain). The key results are illustrated using a familiar example, the inverted pendulum, where significant improvements in guaranteed region of operation and cost are noted.
TRAINING AND COUNSELING ON DISINFECTION DURING REPAIR OF ACRYLIC RESIN DENTURES AT DENTAL LABORATORIES IN SURABAYA AND JEMBER

Background: The dentist who handles a broken acrylic resin denture base case will send the denture to be repaired by a dental technician in the dental laboratory. The transfer of work is likely to pose a risk of cross-infection (for example AIDS, hepatitis, tuberculosis, pneumonia, and herpes. Purpose: To transfer science and technology based on community needs objectively to get a strong foundation in implementing health management for dental technicians. Methods: Training on how to use disinfection materials as well as participatory counseling using slides through LCD projectors, and using props along with interactive discussions and also mentoring when trainees take disinfection measures. Results: The implementation includes 3 activities, that is counseling, training and monitoring Counseling is carried out by providing knowledge about how to disinfect dentures, then training in how to do disinfection, the way is to train dental technicians to disinfect using chlorhexidine by spraying on the denture surface, then monitored. Conclusion: So far the dental laboratory has not carried out any disinfection at the time of denture repair. With counseling and training in this community partnership program, dental technicians know the importance of disinfection denture to prevent cross infection, so that it will then do it.
Comparison of Chronic Hemodialysis Patients under Strict Volume Control with respect to Cardiovascular Disease

Background The objective of this study was to determine the effects of strict volume control and nondipper situation on cardiovascular disease in chronic hemodialysis patients. Methods This study is an observational and cross-sectional study including 62 patients with normotensive chronic hemodialysis using no antihypertensive drugs. A series of measurements including ambulatory blood pressure monitoring, left ventricular mass index by echocardiography, common carotid artery intima-media thickness by ultrasound, and body fluids by bioimpedance analysis were conducted for all subjects. Results The patients were divided into two groups as dippers and nondippers according to their ambulatory blood pressure monitoring results. Average 48 h systolic, diastolic, and mean arterial blood pressure and nocturnal systolic, diastolic, and mean arterial blood pressure were significantly different between the dipper and nondipper groups (p<0.05). Before and after dialysis, extracellular fluid/intracellular fluid and extracellular fluid/dry body weight ratios were significantly higher in the nondipper group. Left ventricle mass index and interventricular septum thickness were significantly higher in the nondipper group (p<0.05). Left ventricle ejection fraction was significantly lower and common carotid artery intima-media thickness was higher in the nondipper group with a statistical significance (p<0.05). A two-predictor logistic model was fitted to the data to predict the comparability of dippers and nondippers. Conclusion According to logistic regression analysis, the odds ratio for daytime diastolic blood pressure indicates that nondippers are 0.45 times more likely to have high blood pressure than dippers in daytime. But in night time, nondippers are about 2.55 times more likely to have high blood pressure comparing to dippers. An important finding of this study is that nondipping pattern is associated with cardiac hypertrophy and lower left ventricle ejection fraction in dialysis of patients with no hypertension. The results also suggest that applying strict volume control to achieve a normal blood pressure alone is not sufficient to reduce the risk of cardiovascular morbidity and mortality if the patients do not have a dipper status of nocturnal blood pressure.
Adaptive Approach to Personalized Learning Sequence Generation

To generate suitable learning sequence according to the student's individual characteristic is a key to build an intelligent tutoring system,and is also an exhibition of intelligence for the system.The difficulty is that both the relationship between the knowledge items should be considered,and the personalized learning characteristics of students should be adapted.In this paper,a learning sequence generation algorithm,which is under the guidance of relationships between knowledge,was proposed.The computation of learning level and the modeling of student personality were described.Based on these,the learning sequence can be optimized.And the detailed adjust and optimization methods were discussed in detail.Learning window was proposed to describe the learning contents and to adapt to the students with different learning abilities,and the learning model was used to distinguish the organization of contents and the corresponding learning styles.The application of the prototype indicates the effectiveness of the proposal,and the prototype system is adaptive to meet students' individual learning needs.
Prognostic value of delta-like protein 3 combined with thyroid transcription factor-1 in small-cell lung cancer

Rovalpituzumab tesirine is a promising delta-like protein 3 (DLL3)-targeted antibody-drug conjugate for the treatment of small-cell lung cancer (SCLC). Thyroid transcription factor-1 (TTF-1) and DLL3 protein are associated with SCLC, and may be used to identify patients, who respond to the DLL3-targeted therapy. However, little is known about the expression pattern of the DLL3 protein, and the prognostic value of DLL3 and TTF-1 for SCLC. A total of 335 patients with SCLC were identified, including 11 patients with paired biopsy of primary site and lobectomy specimens, and 37 patients with paired specimens of primary and metastatic site. The DLL3 expression levels of individuals were evaluated using the anti-DLL3 antibody. No differences in DLL3 expression levels were observed in paired biopsy and lobectomy specimens (P=0.774), and paired primary and metastatic sites (P=0.472). SCLC cases with high DLL3 expression levels were more frequent in male patients (P=0.041), smokers (P=0.023) and patients with positive TTF-1 expression (P=0.006) compared with DLL3-low SCLC. DLL3-high SCLC exhibited worse overall survival compared with DLL3-low SCLC (log-rank test, P=0.007). Patients with TTF-1+ SCLC experienced a significantly worse overall survival compared with patients with TTF-1- SCLC (P<0.001). DLL3-low/TTF-1- was defined as a distinct molecular subgroup of SCLC with optimal prognosis (P<0.001). DLL3-low/TTF-1- was an independent prognostic marker for SCLC (P=0.001). In conclusion, the present study, to the best of our knowledge, provided novel evidence for SCLC intratumoral and intertumoral homogeneity with the identification of DLL3 protein levels. Therefore, it is reliable to use biopsy specimens to evaluate DLL3 expression levels for identification of patients who may benefit from DLL3-targeted therapy. In addition, DLL3 and TTF-1 are two protein markers with potential clinical value in risk stratification for patients with SCLC.
Obtaining Good Heuristics for Big Data Broadcasting Problem Using Novel Pipeline Approach.

– Today big data computing is a critical challenge faced by many industries . Everyday up to terabytes to petabytes of the data is generated in the cloud computing paradigm. Thus there is a drastic demand for building a service to distribute, manage and process massive data sets that has risen tremendously. Engineers and researchers are dealing with these large dataset. In this paper, we investigate the big data broadcasting problem for single source node to broadcast a big chunk of data to a set of nodes with the objective of minimizing the maximum completion time. These nodes may be present in the same data center or across geo distributed data centers. We model the big data broadcasting problem into a LOCKSTEP BROADCAST TREE (LSBT). The main idea of this model is to define a basic unit of upload bandwidth r, such that a node with capacity c broadcast a data to a set of nodes at the rate r. We divide the broadcast data into m chunks. These data chunks can then be broadcasted using a pipeline approach.
Visual e-commerce: Cross-cultural differences between India and Europe

Visualization is important in online shopping. This study investigates the effect of visual product reviews in web shops, with a special interest for cultural differences between online consumers in India and the Netherlands. Two web shops were designed with the same sport shoes. One web shop showed the sport shoes with a visual review. The other web shop showed the same sport shoes with no visual review. 160 consumers from the Netherlands, and 183 consumers from India (mean age 23.4 yrs.) evaluated the products in the two web shop conditions. The Indian consumers had a higher purchase intention than the Dutch consumers. Adding a visual review to the products in the web shop did not result in a higher purchasing intention. The Indian consumers also had a higher (utilitarian) attitude towards the web shop than the Dutch consumers. The recommendation is to include social presence information. This will enhance the persuasive effect of visual product reviews.
An Empirical Analysis of Android Apps Bug and Automated Testing Approach for Android Apps

Android platforms and its applications (apps) have gained tremendous popularity recently, hence the reliability of Android apps is becoming increasingly important. Due to the novelty of the Android platform, apps are prone to errors, which would affect user experience and requires frequent bug fixes. In this paper, an empirical study on bugs in some widely-used open-source Android apps from diverse categories such as media, tools and communication were performed. Based on the findings of the empirical study, an approach for automating the testing process for detecting Android apps GUI bugs was presented. We show how the approach helped to re-discover existing bugs and find new bugs, and how it could be used to prevent certain bug categories. Our empirical study and automated testing approach have the potential to help developers increase the quality of Android apps.
Assessment of training need and training efficacy for national program for prevention and control of cancer, diabetes, cardiovascular diseases and stroke among medical officers of West Bengal, India

Background: The national program for prevention and control of cancer, diabetes, cardiovascular diseases and stroke (NPCDCS) has been rolled out in West Bengal, with its implementation initiated through state-wide training of Medical Officers (M.O). For attaining requisite competency for meeting NPCDCS objectives, MOs have been trained at their respective district levels. Present study aimed to assess the training need, training efficacy and need for further training.Methods: A repeat cross-sectional study was conducted from May-July 2018 for M.Os of six randomly chosen districts of West Bengal, out of those whereat NPCDCS was launched in first phase. 40-45 M.Os were randomly selected from each district in liaison with district level health authorities. The total sample size was 352 with Finite population correction. On the days of training, pre and post training surveys were conducted with an identical semi-structured, pre-tested and validated questionnaire (Cronbach’s alpha >0.8) covering different levels of cognitive domain, with a maximum possible score of 100 marks. No negative marking was done for incorrect responses. Training was imparted by the Principal Investigator (accredited trainer). Ethical clearance was granted by the State Health Directorate. Informed consent from each participant was obtained.Results: Dependent sample t-test revealed significant increment (p<0.0001) in post-test scores (t=63.134) & one-way repeated measure general linear model (GLM) also revealed F=29.617 (p<.0001). The “Effect Size” was classified as “Huge” (Cohen’s D=63.134/√(352)= 3.365), as was noted between pre-test and post-test scores, based on Cohen’s convention and Sawilowsky’s addition. It was further noted that even after six hour training sessions there was 27.44% knowledge gap (p<0.0001) after adjusting for Bonferroni.Conclusions: Imperativeness of training coupled with periodic refresher training has been established as a pre-requisite for successful implementation of NPCDCS.
Acute and Chronic Inflammation Affects Plasma Insulin and Glucagon Levels in Piglets

The present study was performed to examine the influence of acute and chronic inflammation on the plasma insulin and glucagon levels in piglets. The experiment was carried out on young pigs (10-week-old, n=24). Animals (females) were divided into 4 experimental groups: I – control, II – chronic inflammation (overweight), III – acute inflammation, and IV – overweight with acute inflammation. Piglets in groups II and IV received high-calorie diet in order to develop overweight. In order to induce acute inflammation the animals received a single i.p. injection of streptozotocin. Twentyfour hours after injection, blood was taken from all the piglets. Plasma levels of glucose, IL-6, insulin and glucagon were determined using commercial kits. During induced inflammation the plasma level of IL-6 was significantly increased parallel to an elevated level of glucose. Significant changes in the plasma insulin level were observed in piglets in groups III and IV. In contrast, the plasma level of glucagon was significantly decreased under inflammation. The obtained results clearly indicate that higher activity of the immune system, manifested by an elevated cytokine level, may have an impact on the hormones regulating glucose metabolism.
Mental Disorders In The Classical World

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A strengths-based case management intervention to link HIV-positive people who inject drugs in Russia to HIV care

Objective: To determine whether the Linking Infectious and Narcology Care strengths-based case management intervention was more effective than usual care for linking people who inject drugs (PWID) to HIV care and improving HIV outcomes. Design: Two-armed randomized controlled trial. Setting: Participants recruited from a narcology hospital in St. Petersburg, Russia. Participants: A total of 349 HIV-positive PWID not on antiretroviral therapy (ART). Intervention: Strengths-based case management over 6 months. Main outcome measures: Primary outcomes were linkage to HIV care and improved CD4+ cell count. We performed adjusted logistic and linear regression analyses controlling for past HIV care using the intention-to-treat approach. Results: Participants (N = 349) had the following baseline characteristics: 73% male, 12% any past ART use, and median values of 34.0 years of age and CD4+ cell count 311 cells/μl. Within 6 months of enrollment 51% of the intervention group and 31% of controls linked to HIV care (adjusted odds ratio 2.34; 95% confidence interval: 1.49–3.67; P < 0.001). Mean CD4+ cell count at 12 months was 343 and 354 cells/μl in the intervention and control groups, respectively (adjusted ratio of means 1.14; 95% confidence interval: 0.91, 1.42, P = 0.25). Conclusion: The Linking Infectious and Narcology Care strengths-based case management intervention was more effective than usual care in linking Russian PWID to HIV care, but did not improve CD4+ cell count, likely due to low overall ART initiation. Although case management can improve linkage to HIV care, specific approaches to initiate and adhere to ART are needed to improve clinical outcomes (e.g., increased CD4+ cell count) in this population.
Cancer Immunotherapy Therapeutic Manipulation of the CD8-HLA Class I Interaction: Potential and Challenges

The interaction between CD8 and HLA class I is largely monomorphic and of low affinity. Previous studies have indicated that changing the affinity of this interaction can have dramatic biological effects. Reductions in CD8-HLA class I binding affinity can lead to inhibition of T cell mediated target cell killing, whilst modest affinity increases lead to enhanced target cell killing with retained antigenic specificity. Here it is shown that target cells bearing a high affinity chimeric MHC molecule termed a ‘Supertarget’ comprising the HLA-A2 molecule incorporating the murine MHC Kb alpha 3 domain can be killed by T cells irrespective of their native HLA or peptide specificity. We will review the immunotherapy potential of this Supertarget protein and also how novel drugs acting as agonists or antagonists at the CD8-HLA class I interface could have clinical potential.
Immunometabolic cross-talk in the inflamed heart

Inflammatory processes underlie many diseases associated with injury of the heart muscle, including conditions without an obvious inflammatory pathogenic component such as hypertensive and diabetic cardiomyopathy. Persistence of cardiac inflammation can cause irreversible structural and functional deficits. Some are induced by direct damage of the heart muscle by cellular and soluble mediators but also by metabolic adaptations sustained by the inflammatory microenvironment. It is well established that both cardiomyocytes and immune cells undergo metabolic reprogramming in the site of inflammation, which allow them to deal with decreased availability of nutrients and oxygen. However, like in cancer, competition for nutrients and increased production of signalling metabolites such as lactate initiate a metabolic cross-talk between immune cells and cardiomyocytes which, we propose, might tip the balance between resolution of the inflammation versus adverse cardiac remodeling. Here we review our current understanding of the metabolic reprogramming of both heart tissue and immune cells during inflammation, and we discuss potential key mechanisms by which these metabolic responses intersect and influence each other and ultimately define the prognosis of the inflammatory process in the heart.
Fever in the tropics: aetiology and clinical profile of fever of unknown origin in children-a prospective observational study in a tertiary care hospital in South India

Background: Fever of unknown origin (FUO) is an important cause of morbidity and mortality in children, especially in tropical countries with varied aetiology and clinical presentation. Aim of this study is to determine the aetiology and outcome of FUO in Indian children. Study design is Prospective, observational study. Methods: We enrolled 75 children aged 1 to 12 years who were admitted with fever >8 days to the paediatric department from January 2015 to August 2016. Initial evaluation included complete blood count, peripheral smear, urine analysis, chest radiography, blood culture and tuberculin test. Results: In 72 children (96%), a definitive diagnosis could be established, whereas 3 children (4%) remained undiagnosed. Most common aetiology of FUO was infectious disease (90.6%) followed by malignancy (4%) and collagen vascular disease (1.3%). Among the infections group, scrub typhus was found to be the commonest aetiology (52%). Conclusions: Infections were the most common etiological factor for FUO in children aged 1-12 years of our region.