Miracle-dz/UniFAR-FTUs huggingface dataset:
SPITZER OBSERVATIONS OF A1763. II. CONSTRAINING THE NATURE OF ACTIVITY IN THE CLUSTER-FEEDING FILAMENT WITH VLA AND XMM-NEWTON DATA

The A1763 superstructure at z = 0.23 contains the first galaxy filament to be directly detected using mid-infrared observations. Our previous work has shown that the frequency of starbursting galaxies, as characterized by 24 μm emission is much higher within the filament than at either the center of the rich galaxy cluster, or the field surrounding the system. New Very Large Array and XMM-Newton data are presented here. We use the radio and X-ray data to examine the fraction and location of active galaxies, both active galactic nuclei (AGNs) and starbursts (SBs). The radio far-infrared correlation, X-ray point source location, IRAC colors, and quasar positions are all used to gain an understanding of the presence of dominant AGNs. We find very few MIPS-selected galaxies that are clearly dominated by AGN activity. Most radio-selected members within the filament are SBs. Within the supercluster, three of eight spectroscopic members detected both in the radio and in the mid-infrared are radio-bright AGNs. They are found at or near the core of A1763. The five SBs are located further along the filament. We calculate the physical properties of the known wide angle tail (WAT) source which is the brightest cluster galaxy of A1763. A second double lobe source is found along the filament well outside of the virial radius of either cluster. The velocity offset of the WAT from the X-ray centroid and the bend of the WAT in the intracluster medium are both consistent with ram pressure stripping, indicative of streaming motions along the direction of the filament. We consider this as further evidence of the cluster-feeding nature of the galaxy filament.
Recommendations for long-term operational dinsar monitoring of mining-induced deformation in a dynamic agricultural region

Underground mining activities are associated with the potential for surface deformation. DInSAR techniques are known for its ability to successfully measure and monitor deforming areas. However, the limitations associated with this technology are mostly related to signal decorrelation effects which are introduced as a result of the surface and sensor characteristics. In this paper we examine the operational limitations of this technology in the presence of disturbances to the reflected signals, due to the dynamic agricultural nature of the sites under test. Three sources of SAR data captured at X-band, C-band and L-band respectively was considered. The results revealed that changes in the vegetative conditions affected C- and X-band data (as might be expected) more severely, although changes in surface conditions induced by tilling and harvesting also affected L-band data. C-band data could not measure deformation maxima whilst L-band data showed reduced sensitivity to deformation minima.
A Qualitative Inquiry of Childhood and Adolescent Cancer Survivors' Perspectives of Independence.

PURPOSE This report examines facilitators and barriers to independence for a sample of survivors of childhood and adolescent cancer. METHODS We conducted 53 semistructured, in-depth interviews with adult survivors of cancer diagnosed at ages 0-20 years. Researchers qualitatively coded themes to reflect responses to the question inquiring about how cancer may have affected survivors' independence from their parents. RESULTS Among the 21 survivors who reported that cancer affected their independence, themes included challenges and motivators to independence following cancer. Challenges to independence included overprotection by parents, financial dependence, problems in healthcare decision-making, and emotional dependence. Motivators included self-confidence, desire for independence, parental support, and inadequate family support. CONCLUSION Supportive care for survivors of childhood and adolescent cancers should include services to help them in their journey toward developmental independence.
Encoding of amplitude and rate of forces applied to the teeth by human periodontal mechanoreceptive afferents.

1. The encoding of force amplitude and force rate by human periodontal mechanoreceptive afferents was studied. Recordings were obtained from 19 single periodontal afferents in the inferior alveolar nerve with the use of tungsten microelectrodes. Loads consisting of a force increase (loading ramp), a phase of maintained force (static phase), and a force decrease (unloading ramp) were applied to the receptor bearing tooth, which was most often an incisor. The static forces applied ranged between 0.05 and 5 N, and the rate of force applied during the loading ramps ranged between 0.4 and 70 N/s. The forces were primarily applied in one of six directions (lingual, labial, mesial, distal, upward, or downward) that evoked the greatest discharge activity. 2. For each force application, the steady-state response was defined as the mean discharge rate during a 1-s period starting 0.5 s after the end of the loading ramp. Most afferents (15/19) exhibited a "hyperbolic" (viz., negatively accelerating) relationship between the amplitude of the stimulation force and the steady-state response, featuring a pronounced saturation tendency: the highest sensitivity to changes in static force was observed at force levels below 1 N. At higher force levels the sensitivity gradually diminished. Moreover, the dynamic sensitivity similarly decreased with increasing amplitude of static background force. For a subsample of afferents studied, comparable stimulus-response relationships were obtained in directions other than the most responsive one, but the discharge rates were lower. 3. In contrast to the response of most afferents, four (4/19) differed in that they consistently exhibited a nearly linear relationship between force amplitude and the steady-state response. Moreover, these afferents maintained their dynamic sensitivity as the amplitude of the background force was increased. 4. The steady-state response of all afferents was well described as a constant times F/ (F + c), where F represents the steady-state force, and c the force generating one-half the estimated maximum discharge rate that could be evoked by steady-state force stimulation. The c-parameter was on average 0.42 N (range 0.05-1.1 N) for the afferents exhibiting hyperbolic stimulus-response relationships. In contrast it ranged between 5 and 22 N for those exhibiting "nearly linear" relationships. A hypothetical model of the mechanics of the periodontal ligament supporting the F/(F + c) transform is proposed. 5. A general transfer function was developed to predict the instantaneous discharge rate of an individual afferent to arbitrary force profiles applied to the receptor bearing tooth. (ABSTRACT TRUNCATED AT 400 WORDS)
Movement of water, protein and crystalloids between vascular and extravascular compartments in heat‐exposed men during dehydration and following limited relief of dehydration

1. Five male subjects were exposed to a hot environment (43–44° C dry bulb, 28–29° C wet bulb) and allowed to dehydrate for 4 hr. Water was then provided ad libitum for drinking during a 20‐min period; thereafter the subjects continued at rest in the hot room for an additional 140 min.
The Bleeding Time in Pediatrics

When performed with standardized methods and techniques, the bleeding time (BT) depends on variables that physiologically alter primary hemostasis. These variables include number of platelets and platelet function, white and red blood cell counts, vascular factors, hormones, and temperature. Variations within normal limits reflect the in vivo situation and are of no clinical relevance. If the BT is prolonged far above the upper normal limit, however, defects of primary hemostasis have to be anticipated. These include thrombocytopenia or thrombocytopathy, anemia, leukopenia, and deficiencies of plasmatic factors such as von Willebrand factor (vWF), fibrinogen, the lupus anticoagulant, and factor V. The BT can be used as screening test for patients with bleeding symptoms. As a single test, the BT gives the best information in pediatrics, in which defects of primary hemostasis are more common than coagulopathies. In addition, BT can guide the therapy of these patients, because it reflects clinical improvement. When used as a preoperative screening test, BT should be combined with the activated partial thromboplastin time (aPTT) because BT usually does not recognize patients with coagulopathies. With standardized techniques and the knowledge of its merits and limitations, BT is a useful test for diagnosing hemostatic disorders, guiding their therapy, and warning of unexpected bleeding complications during surgery. The BT is especially suited for use in pediatrics for the following reasons: (1) It does not require a venipuncture and is similar to capillary blood sampling if performed with standardized devices adapted for pediatric use; (2) it is an in vivo test informing mostly on defects of primary hemostasis, which are the most common bleeding diatheses in childhood; (3) the results are immediately available; (4) it requires only minimal amounts of blood; and (5) it does not require unphysiological reagents and preparation of the sample. The test requires a highly motivated and experienced operator who knows of the many variables influencing the BT. The interpretation cannot be done without knowledge of the history and physical status of the patient and of the limitations of the BT.
The mechanisms of interhemispheric inhibition in the human motor cortex

Transcranial magnetic stimulation can be used to non‐invasively study inhibitory processes in the human motor cortex. Interhemispheric inhibition can be measured by applying a conditioning stimulus to the motor cortex resulting in inhibition of the contralateral motor cortex. Transcranial magnetic stimulation can also be used to demonstrate ipsilateral cortico‐cortical inhibition in the motor cortex. At least two different ipsilateral cortico‐cortical inhibitory processes have been identified: short interval intracortical inhibition and long interval intracortical inhibition. However, the relationship between interhemispheric inhibition and ipsilateral cortico‐cortical inhibition remains unclear. This study examined the relationship between interhemispheric inhibition, short interval intracortical inhibition and long interval intracortical inhibition. First, the effect of test stimulus intensity on each inhibitory process was studied. Second, the effects of interhemispheric inhibition on short interval intracortical inhibition and long interval intracortical inhibition on interhemispheric inhibition were examined. Motor evoked potentials were recorded from the right first dorsal interosseous muscle in 11 right‐handed healthy volunteers. For interhemispheric inhibition, conditioning stimuli were applied to the right motor cortex and test stimuli to the left motor cortex. For short interval intracortical inhibition and long interval intracortical inhibition, both conditioning stimuli and test stimuli were applied to the left motor cortex. With increasing test stimulus intensities, long interval intracortical inhibition and interhemispheric inhibition decreased, while short interval intracortical inhibition increased. Moreover, short interval intracortical inhibition was significantly reduced in the presence of interhemispheric inhibition. Interhemispheric inhibition was significantly reduced in the presence of long interval intracortical inhibition when matched for test motor evoked potential amplitude but the difference was not significant when matched for test pulse intensity. These findings suggest that both interhemispheric inhibition and long interval intracortical inhibition are predominately mediated by low threshold cortical neurons and may share common inhibitory mechanisms. In contrast, the mechanisms mediating short interval intracortical inhibition are probably different from those mediating long interval intracortical inhibition and interhemispheric inhibition although these systems appear to interact.
Telemedicine: a cautious welcome

Telemedicine is a major new development. Having become technically and economically feasible, it deserves proper investigation. Rushing into equipment purchase, however, is almost certain to prove counterproductive. Face to face contact is fundamental to health care and enthusiasts of telemedicine should recognise that it is not as good as the real thing (and unlikely ever to be). However, constraints on time and resources will make face to face consultation increasingly expensive, and telemedicine has the potential to produce major efficiencies in the diagnostic process. The goal of current research is therefore to marry medicine with technology, capitalising on the advantages of telemedicine and producing a robust system that delivers an acceptable service at an appropriate price.
Graduación Histológica de Malignidad en el Carcinoma Ductal Infiltrante de la Mama. Hospital UniversitarioV.I.Lenin

El grado histologico de malignidad constituye un reflejo de la diferenciacion celular y es ampliamente utilizado entre los factores pronosticos clasicos para el cancer de mama. En nuestra investigacion , aplicamos el sistema de graduacion histologica de ScarffBloomRichardson en una serie de 51 casos diagnosticados consecutivamente en el Departamento de Anatomia Patologica del Hospital Universitario “V. I. Lenin ” de Holguin, con el objetivo de determinar la variabilidad diagnostica entre diferentes observadores, los cuales clasificaron los casos de forma individual y sin conocimiento previo del diagn ostico de los demas. Obtuvimos como resultados un 36.47% de coincidencia diagnostica en el grado histologico, siendo el pleomorfismo nuclear el aspecto que m as influyo en el mismo.
Restos Humanos Asociados a la Pirámide de Akapana (Tiwanaku, Bolivia)

Resumen Este trabajo proporciona datos sobre las recientes excavaciones llevadas a cabo en la estructura de Akapana, Tiwanaku, Bolivia. Esta es la construcción religiosa más masiva y alta del sitio. Después de mencionar algunos datos de las temporadas de campo 1988 y 1989, se describe una serie de restos parciales humanos articulados, ubicados en un ángulo remetido del sector norte de la estructura. Los autores ofrecen una serie de hipótesis alternativas para explicar este patrón, poniendo especial énfasis en la componente ritual.
A Granular Classifier By Means of Context-based Similarity Clustering

In this study, we propose a granular classifier (GC) with the aid of a context-based similarity clustering (CSC) method and applied it for network intrusion detection. The proposed CSC supporting the design of information granules is exploited here to determine the so-called contexts. Unlike the conventional similar clustering method, here the CSC built clusters by taking into consideration of both input data and output data. The design of granular classifier is realized based on the if-then rules, which consists two parts: namely premise part and conclusion part. The premise part is developed by using the CSC, while the conclusion part is realized with the aid of supported vector machines. In contrast to typical rule-based classifier, the underlying principle exploited here is to consider a robust classification with the adequate use of output data. In particular, rule-based classifiers or supported vector machines can be regarded as a special case of the proposed granular classifier. Numeric studies show the superiority of the proposed approach.
[Multislice spiral CT of the paranasal sinuses: first experiences using various parameters of radiation dosage].

PURPOSE To evaluate the potential of multislice CT in the diagnosis of the paranasal sinuses. METHODS Dose measurements were performed exposing an Alderson Rando phantom in a four-slice spiral CT (MS-CT) while applying a variety of scan parameters. Additionally, 30 consecutive patients underwent a transversal examination by the MS-CT using 1/1/3.5/0.5 mm spiral parameters and an additional transversal or coronal scan on a conventional single slice spiral CT (SS-CT) with 2/3/1 mm. Coronal reformations of the MS-CT were compared with the primary coronal SS-CT, or coronal reformations of the transversal SS-CT, respectively, with regard to image quality and depiction of relevant anatomical details of the region. RESULTS Superficial exposure values at the level of the eye lenses as well as for the thyroid gland were superior for MS-CT (3.62 mGy, and 0.12 mGy, resp.) as compared to SS-CT (2.96 mGy, and 0.07 mGy). Image quality was equal or superior for MS-CT as compared to SS-CT in all but one case. Drawbacks of SS-CT, such as dental amalgam artifacts, stair step artifacts or partial volume artifacts did not notably affect the coronal reformations of MS-CT. CONCLUSION MS-CT seems to have the potential to replace primary coronal CT of the paranasal sinuses without any loss of image quality, but may even improve the overall diagnostic value. Radiation doses may still have to be reduced.
miR-7 reverses the resistance to BRAFi in melanoma by targeting EGFR/IGF-1R/CRAF and inhibiting the MAPK and PI3K/AKT signaling pathways

MicroRNAs (miRNAs) are attractive therapeutic targets for various therapy-resistant tumors. However, the association between miRNA and BRAF inhibitor resistance in melanoma remains to be elucidated. We used microarray analysis to comprehensively study the miRNA expression profiling of vemurafenib resistant (VemR) A375 melanoma cells in relation to parental A375 melanoma cells. MicroRNA-7 (miR-7) was identified to be the most significantly down-regulated miRNA in VemR A375 melanoma cells. We also found that miR-7 was down-regulated in Mel-CVR cells (vemurafenib resistant Mel-CV melanoma cells). Reestablishment of miR-7 expression could reverse the resistance of both cells to vemurafenib. We showed that epidermal growth factor receptor (EGFR), insulin-like growth factor-1 receptor (IGF-1R) and CRAF were over-expressed in VemR A375 melanoma cells. Introduction of miR-7 mimics could markedly decrease the expressions of EGFR, IGF-1R and CRAF and further suppressed the activation of MAPK and PI3K/AKT pathway in VemR A375 melanoma cells. Furthermore, tumor growth was inhibited in an in vivo murine VemR A375 melanoma tumor model transfected with miR-7 mimics. Collectively, our study demonstrated that miR-7 could reverse the resistance to BRAF inhibitors in certain vemurafenib resistant melanoma cell lines. It could advance the field and provide the basis for further studies in BRAF inhibitor resistance in melanoma.
The Trypanocidal Activity of Naphthoquinones: A Review

Naphthoquinones are compounds present in several families of higher plants. Their molecular structures confer redox properties, and they are involved in multiple biological oxidative processes. In folk medicine, especially among Indian populations, plants containing naphthoquinones have been employed for the treatment of various diseases. The biological redox cycle of quinones can be initiated by one electron reduction leading to the formation of semiquinones, unstable intermediates that react rapidly with molecular oxygen, generating free radicals. Alternatively, the reduction by two electrons, mediated by DT-diphorase, leads to the formation of hydroquinone. Lapachol, α-lapachone and β-lapachone, which are isolated from the heartwood of trees of the Bignoniaceae family, are examples of bioactive naphthoquinones. In this review, we will discuss studies investigating the activity of these natural products and their derivatives in the context of the search for alternative drugs for Chagas disease, caused by Trypanosoma cruzi, a neglected illness that is endemic in Latin America.
Multi-dimensional Query Authentication for On-line Stream Analytics

Database outsourcing is unavoidable in the near future. In the scenario of data stream outsourcing, the data owner continuously publishes the latest data and associated authentication information through a service provider. Clients may register queries to the service provider and verify the result's correctness, utilizing the additional authentication information. Research on On-line Stream Analytics (OLSA) is motivated by extending the data cube technology for higher multi-level abstraction on the low-level-abstracted data streams. Existing work on OLSA fails to consider the issue of database outsourcing, while previous work on stream authentication does not support OLSA. To close this gap and solve the problem of OLSA query authentication while outsourcing data streams, we propose MDAHRB and MDAHB, two multi-dimensional authentication approaches. They are based on the general data model for OLSA, the stream cube. First, we improve the data structure of the H-tree, which is used to store the stream cube. Then, we design and implement two authentication schemes based on the improved H-trees, the HRB- and HB-trees, in accordance with the main stream query authentication framework for database outsourcing. Along with a cost models analysis, consistent with state-of-the-art cost metrics, an experimental evaluation is performed on a real data set. It exhibits that both MDAHRB and MDAHB are feasible for authenticating OLSA queries, while MDAHRB is more scalable.
NÍVEL DE ATIVIDADE FÍSICA EM MULHERES IDOSAS Level of physical activity in elderly women

RESUMO Objetivo: Avaliar os niveis de atividade fisica (NAF) em mulheres idosas praticantes de atividades fisicas acompanhadas por uma equipe de Saude da Familia da cidade do CratoCE, Brasil. Metodos: Para determinar o nivel de atividade fisica, utilizou-se o Questionario Baecke Modificado para Idosos (QBMI). Na avaliacao estatistica das diferencas obtidas utilizou-se o teste “t” de Student, com nivel de significância de p<0,05 e o tamanho-efeito. Resultados: Comparando-se o nivel de atividade fisica, conforme classificacao do QBMI, das idosas que praticavam caminhada (67,2% do total, NAF = 4,45, classificado como alto) com as idosas que realizavam somente atividades domesticas (54.1%, NAF = 1,71, baixo), observou-se um D% = 160, 24%, p<0,001. O indice d de Conhen que expressa a magnitude desta diferenca foi de 6,23 (alto). Conclusao: De acordo com os resultados, infere-se que a pratica de atividade fisica regular, como a caminhada, e capaz de melhorar os niveis de atividade motora em pessoas idosas.