Miracle-dz/UniFAR-FTUs huggingface dataset:
Direct Evidence of the Overshoot Suppression in Ta2O5-Based Resistive Switching Memory With an Integrated Access Resistor

We demonstrate suppression of the overshoot current effect on a resistive random access memory device with a TiN/Ta2O5/TaOx/TaN/TiN stack structure. Using test structures with an integrated 5-kΩ series resistor, a nearly 1:1 relation between the compliance current and the first maximum reset current has been achieved, together with an opening of the ON/OFF resistance window to over 100. Besides, the cell size also plays an important role on overshoot suppression, which we relate to the effect of the device self-capacitance discharge during the set switching. According to the experimental results, a simple model for the access circuitry is proposed, which is able to explain well the overshoot impact, by identifying the main capacitance discharge loops during device operation.
Combattre l'illettrisme : permis de lire, permis de vivre...

Guide technique et methodologique, l'ouvrage developpe une triple demarche: s'appuyant sur une connaissance du public et s'articulant sur des temoignages d'apprenants, elle decrit differents profils et niveaux d'illettrisme, elle definit des pistes d'action en proposant un dispositif de formation qui se veut efficace, elle met en avant une pedagogie de la communication et presente un contenu et des exercices a partir de themes en lien avec la vie quotidienne des personnes illettrees (p. 4 de la couv.).
New cluster ensemble approach to integrative biological data analysis

Clinical data has been employed as the major factor for traditional cancer prognosis. However, this classic approach may be ineffective for analysing morphologically indistinguishable tumour subtypes. As such, microarray technology emerges as the promising alternative. Despite a large number of microarray studies, the actual clinical application of gene expression data analysis remains limited owing to the complexity of generated data and the noise level. Recently, the integrative cluster analysis of both clinical and gene expression data has been shown to be an effective alternative to overcome the above-mentioned problems. This paper presents a novel method for using cluster ensembles that is accurate for analysing heterogeneous biological data. Evaluation against real biological and benchmark data sets suggests that the quality of the proposed model is higher than many state-of-the-art cluster ensemble techniques and standard clustering algorithms.
The Frequency Diverse Bistatic System

In this paper we analyze the Frequency Diverse Array (FDA), modifying some of its characteristics. Through a reconsideration of the organization of the array, which we termed “Wavelength Array” (WA), a new pattern, ‘orthogonal’ to the standard phased array, can be achieved. The bistatic combination of a WA and a receiver originates the ‘Frequency Diverse Bistatic System’ (FDBS), which can be a significant application of this concept.
Design Of An Actuator Being Both A Permanent Magnet Synchronous Motor And A Magnetic Suspension

An original structure of a bearingless motor is theoretically proposed. Using an octopolar permanent magnet synchronous motor, the four active radial axes of a magnetic suspension are generated by supplying some coils of the motor circuit with additional control currents. Following a given sequence, these control currents have to be modified depending on the rotor position in order to give a force that is independent of the rotor position. The most appropriate command strategy is described and theoretically validated. The working principle does not disturb the generated motor torque and the functioning of the actuator. The electric drive of this bearingless actuator is studied and the principal drawbacks are discussed.
Ranging results using a UWB platform in an indoor environment

This paper presents an impulse-radio UWB experimental platform for ranging and positioning in GNSS-challenged environments. The platform is based on the two-way time-of-arrival principle of operation, which reduces architecture complexity and relaxes the synchronization requirements with respect to time-of-arrival or time-difference-of-arrival solutions. The modular architecture of the platform is described together with the design and features of its main components, namely the 5.6-GHz RF front end and the baseband module for measurement and processing. A set of experimental results obtained using the realized platform in an indoor office environment is presented and discussed. The platform provides a maximum range of about 30 m in line-of-sight conditions with an RMSE of the order of 40 cm.
PIFs: Systems Integrators in Plant Development[W]

Phytochrome-interacting factors (PIFs) are members of the Arabidopsis thaliana basic helix-loop-helix family of transcriptional regulators that interact specifically with the active Pfr conformer of phytochrome (phy) photoreceptors. PIFs are central regulators of photomorphogenic development that act to promote stem growth, and this activity is reversed upon interaction with phy in response to light. Recently, significant progress has been made in defining the transcriptional networks directly regulated by PIFs, as well as the convergence of other signaling pathways on the PIFs to modulate growth. Here, we summarize and highlight these findings in the context of PIFs acting as integrators of light and other signals. We discuss progress in our understanding of the transcriptional and posttranslational regulation of PIFs that illustrates the integration of light with hormonal pathways and the circadian clock, and we review seedling hypocotyl growth as a paradigm of PIFs acting at the interface of these signals. Based on these advances, PIFs are emerging as required factors for growth, acting as central components of a regulatory node that integrates multiple internal and external signals to optimize plant development.
Le rôle du pharmacien d'officine dans la prise en charge du cancer du sein

Le cancer du sein represente plus de 31% de tous les cancers chaque annee, avec 50.000 nouveaux cas et environ 10.000 morts. A l'heure actuelle, differents facteurs de risque sont averes (genetiques, environnementaux, âge et sexe, hormonaux, hygienodietetiques) et permettent tout comme le depistage organise un diagnostic plus precoce ce qui augmente les chances de guerison. La prise en charge therapeutique est basee sur 4 grands axes : chirurgie, chimiotherapie, radiotherapie et hormonotherapie responsables de nombreux effets indesirables. Le suivi de la maladie par un professionnel de sante tel que le pharmacien d'officine devient essentiel notamment pour une meilleure gestion des effets indesirables. Celui-ci aura egalement un role d'ecoute, d'accompagnement et de conseils aupres de la patiente tout au long de sa maladie. Il se devra de pouvoir repondre a certaines interrogations de sa patiente, notamment sur le depistage, le diagnostic et la prise en charge. Lors de la delivrance des divers medicaments, le pharmacien pourra prodiguer a la patiente quelques conseils alimentaires, lui remettre des fiches destinees aux patients sur les chimiotherapies orales. Enfin, le pharmacien pourra etre amene a prendre les mesures pour la delivrance de protheses mammaires, de manchon. Le pharmacien d'officine a une place importante dans la prise en charge pluridisciplinaire du cancer du sein.
Increase in congenital rubella occurrence after immunisation in Greece: retrospective survey and systematic review.

Abstract Objective: To describe the events leading to the epidemic of congenital rubella syndrome in Greece in 1993 after a major rubella epidemic. Design: Retrospective survey and systematic review. Setting: Greece (population 10 million), 1950-95. Subjects: Children, adolescents, and women of childbearing age. Results: Around 1975 in Greece the measles, mumps, and rubella vaccine started being given to boys and girls aged 1 year without policies to attain high vaccination coverage and to protect adolescents and young women During the 1980s, vaccination coverage for rubella remained consistently below 50%, and the proportion of pregnant women susceptible to rubella gradually increased. In 1993 the incidence of rubella in young adults was higher than in any previous epidemic year. The epidemic of congenital rubella that followed, with 25 serologically confirmed cases (24.6 per 100 000 live births), was probably the largest such epidemic in Greece after 1950. Conclusions: With low vaccination coverage, the immunisation of boys and girls aged 1 year against rubella carries the theoretical risk of increasing the occurrence of congenital rubella. This phenomenon, which has not been previously reported, occurred in Greece.
The Computational Experiment: an Econometric Tool

An economic experiment consists of the act of placing people in an environment desired by the experimenter, who then records the time paths of their economic behavior. Performing experiments that use actual people at the level of national economies is obviously not practical, but constructing a model economy and computing the economic behavior of the model's people is. Such experiments are termed computational. This essay specifies the steps in designing a computational experiment to address some well-posed quantitative question. The authors emphasize that the computational experiment is an econometric tool used in the task of deriving the quantitative implications of theory.
The Cost of Dementia in Denmark: The Odense Study

In a population-based study of dementia, the cost of care for 245 demented elderly and 490 controls matched by age and gender was estimated. Dementia of Alzheimer’s type was diagnosed according to the NINCDS-ADRDA criteria, and vascular dementia and other types of dementia were diagnosed according to the DSM-IIIR criteria. Severity of dementia was determined by the Clinical Dementia Rating scale. The annual cost of medical care, domestic care, home help, nursing home and special equipment for nondemented patients was DKK 22,000 per person while the cost for very mildly, mildly, moderately and severely demented patients was DKK 49,000, DKK 93,000, DKK 138,000 and DKK 206,000, respectively. Except for very mild dementia the cost did not differ between elderly who suffer from Alzheimer’s disease and those with other types of dementia. The net cost of dementia is the difference in cost between those with dementia and the matched controls and amounts on average to DKK 77,000 per person per year. However, priority setting cannot be based on the cost of dementia per se, but only on the cost of a specific dementia intervention compared to its health benefit.
Clinical Characteristics of Bacteremia Caused by Extended-spectrum Beta-lactamase-producing Escherichia coli at a Tertiary Hospital

Objective In recent years, infection caused by extended-spectrum beta-lactamase (ESBL)-producing organisms has become an important issue. However, comparative studies of the bacteremia caused by ESBL Enterobacteriaceae and non-ESBL Enterobacteriaceae are extremely rare in Japan. This study aimed to assess the risk factors and prognosis of patients with bacteremia due to ESBL Escherichia coli (E. coli). Methods The medical records of 31 patients with ESBL E. coli bacteremia and 98 patients with non-ESBL E. coli bacteremia who had been admitted to Osaka City University Hospital between January 2011 and June 2015 were retrospectively reviewed. The patient backgrounds, risk factors for infection, and prognosis were evaluated. Results The male-to-female ratio, mean age, underlying disease, leukocyte count, and C-reactive protein (CRP) level did not differ between the patients in the ESBL E. coli bacteremia and non-ESBL E. coli bacteremia groups. The mean Sequential Organ Failure Assessment (SOFA) score for patients with ESBL and non-ESBL E. coli bacteremia were 3.6 and 3.8, respectively. Further, the mortality did not differ between the two groups (9.7% vs 9.2%). However, the independent predictors associated with ESBL E. coli bacteremia according to a multivariate analysis were the use of immunosuppressive drugs or corticosteroids (p=0.048) and quinolones (p=0.005) prior to isolation. The mortality did not differ between the carbapenem and tazobactam/piperacillin (TAZ/PIPC) or cefmetazole (CMZ) groups for the patients with ESBL E. coli bacteremia. Conclusion Whenever we encountered patients with a history of immunosuppressive drug, corticosteroid, quinolone administration, it was necessary to perform antibiotic therapy while keeping the risk of ESBL E. coli in mind.
Book Marketing and the Booker Prize

‘Tension is as high in Bungay [the Suffolk town where Clays is based] as it is in the Guildhall on the night The Booker Prize winner is announced. Traditionally, the publisher of the winning book immediately rings the printer to arrange an instant reprint. In 1997, for example, the Clays Account Controller watched The Booker Prize presentation on television and at 9.59 pm saw that The God of Small Things had won. By 10 pm a 20,000 copy reprint had been confirmed and Clays went into overnight production. Within 24 hours the books were printed and on their way into bookshops all over the country. Sales were so strong that, three days later, HarperCollins placed an order for a second reprint of yet another 20,000 copies, this time with ‘Booker Prize Winner’ emblazoned on the cover’ (Clays 1998, 58).
A Pathway for the Control of Anoikis Sensitivity by E-Cadherin and Epithelial-to-Mesenchymal Transition

ABSTRACT Detachment of epithelial cells from matrix or attachment to an inappropriate matrix engages an apoptotic response known as anoikis, which prevents metastasis. Cellular sensitivity to anoikis is compromised during the oncogenic epithelial-to-mesenchymal transition (EMT), through unknown mechanisms. We report here a pathway through which EMT confers anoikis resistance. NRAGE (neurotrophin receptor-interacting melanoma antigen) interacted with a component of the E-cadherin complex, ankyrin-G, maintaining NRAGE in the cytoplasm. Oncogenic EMT downregulated ankyrin-G, enhancing the nuclear localization of NRAGE. The oncogenic transcriptional repressor protein TBX2 interacted with NRAGE, repressing the tumor suppressor gene p14ARF. P14ARF sensitized cells to anoikis; conversely, the TBX2/NRAGE complex protected cells against anoikis by downregulating this gene. This represents a novel pathway for the regulation of anoikis by EMT and E-cadherin.
Clinical and molecular approaches to well differentiated and dedifferentiated liposarcoma

Purpose of review Liposarcoma, a rare disease, is classified into five histologic subtypes. These include well differentiated liposarcoma (WDLS) and dedifferentiated liposarcoma (DDLS), both characterized by chromosome 12q13-15 amplification. This review will focus on the clinical management of WDLS and DDLS and examine recent molecular studies that have the potential to affect clinical management. Recent findings Outcome of patients with WDLS and DDLS depends on completeness of surgical resection as well as tumor location and histologic subtype. Risk of recurrence is high for patients with dedifferentiated histology or retroperitoneal location. We now understand that surgical outcomes are poor for patients with rapidly growing or incompletely resectable tumors, so these patients should be managed nonoperatively. Radiation and chemotherapy have low response rates in WDLS and DDLS, but novel agents targeted at chromosome 12 gene products MDM2 and CDK4 have shown promise in preclinical studies and are being tested in clinical trials. Cell line, tissue microarray, and genomic analyses have identified additional targets including ZIC1, TOP2A, AURKA, and IGF-1R, which could form the basis of future therapies. Summary Although complete surgical resection is currently the most effective treatment for WDLS and DDLS, the majority of patients with retroperitoneal liposarcoma will eventually have recurrence and die of disease. It is hoped that a multimodality approach, which incorporates targeted therapies and complete surgical resection, will significantly improve patient outcomes.
Evaluierung des Tonovet®-Reboundtonometers in der klinischen Anwendung bei Hund und Katze

Zusammenfassung Gegenstand und Ziel: Evaluierung des Tonovet®-Reboundtonometers an einer größeren Anzahl augengesunder Hunde und Katzen mit Überprüfung einer Beeinflussung der Messungen durch ein von der Herstellerempfehlung abweichendes Handling des Geräts. Material und Methode: Bei 100 augengesunden Hunden (n = 80) und Katzen (n = 20) verschiedener Rassen (Beagle, Teckel, Retriever, brachyzephale Hunde und Europäisch-Kurzhaar-Katzen) erfolgte die beidseitige Messung des Augeninnendrucks mittels Tonovet® gemäß Herstellerangaben (Referenzmessung) sowie unter Variation verschiedener Parameter des Handlings (Messlokalisation, Auftreffwinkel, Messabstand). Im Anschluss wurde eine Vergleichsmessung mit dem Applanationstonometer Tonopen Vet® durchgeführt. Ergebnisse: Bei den Hunden (160 Augen) ergab sich für das Tonovet® ein mittlerer Augeninnendruck (± Standardabweichung [SD]) von 13,7 mmHg (SD 2,9 mmHg), während mit dem Tonopen Vet® im Mittel 12,9 mmHg (SD 3,1 mmHg) gemessen wurden. Für die Katzen (40 Augen) ließ sich mittels Tonovet® ein mittlerer Augeninnendruck von 16,7 mmHg (SD 3,0 mmHg) und mittels Tonopen Vet® ein mittlerer Wert von 17,4 mmHg (SD 3,0 mmHg) ermitteln. Ein von der Herstellerempfehlung abweichendes Handling des Tonovet® beeinflusste die Messwerte höchst signifikant. Im Vergleich zur Referenzmessung ergaben sich für periphere Messlokalisationen in ca. 1,5 mm Abstand vom Limbus und einen verringerten Messabstand von weniger als 4 mm geringfügige Abweichungen der Messwerte nach oben. Ein Abkippen der Messachse hingegen führte zu erheblich niedrigeren Augeninnendruckwerten. Schlussfolgerung und klinische Relevanz: Die Anwendung des Tonovet® erweist sich bei Hund und Katze als praktikable Alternative zum bereits etablierten Tonopen Vet®, die auch von Katzen sehr gut toleriert wird. Das Handling des Geräts erfordert jedoch die Berücksichtigung potenzieller Fehlerquellen, die eine Verfälschung der Messwerte zur Folge haben können.
Iron-mediated cardiovascular injury

Iron is an essential element for normal cellular function and general health. However, iron may play a pathologic role in certain cardiac conditions including reperfusion injury, hemochromatosis, b-thalassemia and coronary atherosclerosis. It also may play a role in injury due to anthracycline cardiotoxicity. Removal of iron via phlebotomy for hemochromatosis and chelation therapy for b-thalassemia are proven treatments. Cell culture, and isolated organ and animal studies suggest that depleting iron stores may prevent reperfusion injury, restenosis and even atherogenesis. This article will review mechanisms by which iron overload states and normal iron stores contribute to cardiovascular pathophysiology and the accumulating evidence that iron chelation may prevent restenosis and atherogenesis.
Adherence to HEp-2 cells and enteropathogenic potential of Aeromonas spp.

SUMMARY Aeromonas strains (total = 60) of clinical, water and food origin were tested for adherence to HEp-2 cells. Environmental strains were selected (except for A. caviae) to include primarily those expressing other virulence-associated properties. Adhesion was markedly species-dependent (A. veronii biotype sobria, 15 of 20 [58%], A. caviae, 4 of 12 [33%] and A. hydrophila, 2 of 8 [11%]). A. veronii biotype sobria were adhesive, irrespective of source (62 and 54% for clinical and environmental strains, respectively). Adherent strains of this species were enterotoxin-positive and most (13 of 15) grew at 43 °C. A. caviae isolated from clinical specimens contained a higher proportion (75%) of adherent strains than environmental strains (13%). Virulent subsets of A. veronii biotype sobria and A. caviae are adherent to HEp-2 cells. The HEp-2 assay is a useful model for investigating mechanisms of adherence and enteropathogenicity of virulent Aeromonas species.
Daily energy expenditure by man

Energy expenditure in man 83 expenditure. Calorie balance in this instance was achieved, not on a daily or monthly basis, but only over a period of a year. These results indicate the need for further studies, combining energy-expenditure measurements with food-intake records, on people following different occupations. The two sides of the inquiry illumine each other: the one does not replace the other.
Identification, Sequence Analysis, and Comparative Study on GSTe2 Insecticide Resistance Gene in Three Main World Malaria Vectors: Anopheles stephensi, Anopheles culicifacies, and Anopheles fluviatilis

Abstract Glutathione S-transferases (GSTs) are soluble dimeric proteins that are involved in the metabolism, detoxification, and excretion of a large number of endogenous and exogenous compounds such as insecticides from the cell. In the current study, field specimens of Anopheles stephensi Liston, Anopheles fluviatilis James, and Anopheles culicifacies Giles collected from Sistan and Baluchistan province in Iran and subjected to World Health Organization susceptibility test. Only An. stephensi was resistant to 4% DDT. DNA extraction and rDNA-ITS2-polymerase chain reaction (PCR) for correct species identification, followed by amplification of GSTe2 gene, including exon I and II and full sequence of intron I, identified a 500-bp fragment in these three species. These fragments were purified and sequenced from both ends. The comparison of coding sequence of GSTe2 gene between these species and with Anopheles gambiae Giles showed 82 to 86% similarity at nucleic acid levels and identified nucleotide polymorphisms within An. culicifacies and An. stephensi populations. Species-specific differences have been detected in intron I of GSTe2 gene. This is in concordance with the previous studies and confirmed the conserved nature of intron sequence in GSTe2 gene of each species, probably useful as a molecular marker for species-specific identification. Phylogenetic analysis based on rDNA-ITS2, and coding (exon I and II) and noncoding sequences of GSTe2, showed the systematic relatedness between Iranian malaria vectors and the possibility of using these sequences in both differentiation of Anopheles species and defining their evolutionary relationship with the only available GSTe2 sequence of An. gambiae. These data may be useful for implementation and evaluation of malaria control programs in aspects of population genetics and molecular resistance.
HBV and HCV Therapy

One year of interferon therapy inhibits HBV replication in one third of the patients whereas long-term administration of oral nucleos(t)ide analogues is efficient in most of them, as long as early treatment adaptation in patients with partial virological response and resistance is provided. Following the demonstration of a more potent antiviral effect in terms of sustained virological response (SVR) rates, Pegylated-IFN coupled with Ribavirin has become the standard treatment for chronic hepatitis C, with nearly 65% of all treated patients achieving a SVR. Long-term suppression of HBV and eradication of HCV would halt the progression of chronic hepatitis to cirrhosis, hepatocellular carcinoma and liver decompensation.