Miracle-dz/UniFAR-FTUs huggingface dataset:
Häufigkeit und Prädiktoren der mikrovaskulären Obstruktion bei Patienten mit Nicht-ST-Hebungsinfarkt

Ziel der vorliegenden Arbeit war es die Haufigkeit und Pradiktoren einer moglichen mikrovaskularen Obstruktion bei Patienten mit Nicht-ST-Hebungsinfarkt (NSTEMI) zu erfassen. An der Studie nahmen 190 Patienten mit einem NSTEMI teil. Diese erhielten innerhalb von 24 Stunden nach Klinikaufnahme eine Koronarangiographie und eine perkutane Koronarintervention. Die Bildgebung mit kardinaler Magnetresonanztomographie (CMR) erfolgte im Mittel 4,1 Tage nach der Angiographie. Bei 13.8% der NSTEMI-Patienten mit fruhzeitiger PCI war eine nach CMR-Bildgebung definierte mikrovaskulare Obstruktion nachweisbar. Die Lokalisation der fuhrenden Lasion im Ramus circumflexus der linken Koronararterie und eine grosere Infarktausdehnung stellten sich dabei als unabhangige Risikofaktoren fur eine mikrovaskulare Obstruktion bei Patienten mit NSTEMI heraus.
The anatomy and pathophysiology of the optic nerve head in glaucoma.

Over the past 10 years, the normal and glaucomatous optic nerve head (ONH) has been studied within four broad areas. First, ongoing characterizations of the normal anatomy, physiology, and aging of the ONH tissues have been expanded to the cellular level. Second, the vasculature of the anterior opti
Method for partial recovering source code of telecommunication devices for vulnerability search

The article describes a automated method for searching of low level and medium level vulnerabilities in machine code, which is based on its partial recovering. Vulnerability search is positioned in the field of telecommunication devices. Typical vulnerabilities in source code and algorithms for its search is given. There is forecast to develop methods and utilities in the near future.
Replicate divergence between and within sounds in a marine fish: the copper rockfish (Sebastes caurinus)

Understanding the factors that influence larval dispersal and connectivity among marine populations is critical to the conservation and sustainable management of marine resources. We assessed genetic subdivision among ten populations of copper rockfish (Sebastes caurinus) representing paired samples of outer coast and the heads of inlets in five replicate sounds on the west coast of Vancouver Island, British Columbia, using 17 microsatellite DNA loci. Overall, subdivision (FST) was low (FST = 0.031, P < 0.001), but consistently higher between paired coast and head of inlet sites (mean FST = 0.047, P < 0.001) compared to among the five coast sites (mean FST = −0.001, P > 0.5) or among the five head of inlet sites (mean FST = 0.026, P < 0.001). Heterozygosity, allelic richness and estimates of effective population size were also lower in head of inlet sites than in coast sites. Bayesian analysis identified two genetic groups across all samples, a single genetic group among only coast samples, two genetic groups among head of inlet samples and two genetic groups within each sound analysed separately. Head of inlet copper rockfish tended to be shorter with lower condition factors and grew more slowly than coast sites fish. Reduced physical connectivity and selection against immigrants in contrasting outer coast–head of inlet environments likely contribute to the evolution of population structure of copper rockfish. Based on genetic connectivity, coast sites appear to be better served by existing marine protected areas than are head of inlet sites.
Short-form Tai Chi Improves Standing Balance of People With Chronic Stroke

Background and Objective. Our previous findings showed that 4 weeks of intensive Tai Chi practice improved standing balance in healthy seniors. This study set out to investigate whether Tai Chi could improve standing balance in subjects with chronic stroke. Methods. One hundred thirty-six subjects >6 months after stroke were randomly assigned to a control group (n = 62) practicing general exercises or a Tai Chi group (n = 74) for 12 weeks of training. Each week, 1 hour of group practice was supplemented by 3 hours of self-practice. We used a short-form of Tai Chi consisting of 12 forms that require whole-body movements to be performed in a continuous sequence and demands concentration. A blinded assessor examined subjects at baseline, 6 weeks (mid-program), 12 weeks (end-program), and 18 weeks (follow-up). The 3 outcome measures were (1) dynamic standing balance evaluated by the center of gravity (COG) excursion during self-initiated body leaning in 4 directions, (2) standing equilibrium evaluated in sensory challenged conditions, and (3) functional mobility assessed by Timed-up-and-go score. Mixed model repeated-measures analysis of variance was used to examine between-group differences. Results. When compared with the controls, the Tai Chi group showed greater COG excursion amplitude in leaning forward, backward, and toward the affected and nonaffected sides (P < .05), as well as faster reaction time in moving the COG toward the nonaffected side (P = .014) in the end-program and follow-up assessments. The Tai Chi group also demonstrated better reliance on vestibular integration for balance control at end-program (P = .038). However, neither group improved significantly in Timed-up-and-go scores. Conclusions. Twelve weeks of short-form Tai Chi produced specific standing balance improvements in people with chronic stroke that outlasted training for 6 weeks.
Analog and digital performance of multiple discrete time delays based on a fiber loop with an internal frequency shifter

A fiber loop with an internal frequency shifter is used to produce the delayed copies of an incoming data signal. The linear phase response of the system is verified and the spurious free dynamic range (SFDR) is measured. Also, the BER and constellation diagrams of 10Gbaud QPSK signals are obtained.
Testbed for High-Speed 'End-to-End' Communications in Support of Comprehensive Emergency Management

As part of the project "Testbed for High-Speed End-to-End Communications in Support of Comprehensive Emergency Management" funded by the National Science Foundation's Digital Government Program (award EIA- 9983463), Virginia Tech researchers are developing a prototype system to provide a high-speed backbone network for emergency and disaster response. It is intended to utilize a geographic information system (GIS) tool developed at Virginia Tech for rapid site planning and incorporate adaptive data link protocols based on a low-cost channel sounder, also developed at Virginia Tech, that will assess channel quality. Figure 1 displays a system concept for the given GIS map.
Influence of n‐3 fatty acids on blood lipids in normal subjects

Abstract. The effects of consuming oils providing alpha‐linolenic (ALA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids were studied in healthy volunteers. A blunted increase in plasma triglyceride was observed in subjects given a test meal containing fish oil compared with olive oil; cholesterol concentrations were not increased; increases in EPA and DHA were seen in all lipid fractions. In longer term supplementation studies, ALA increased EPA, but not DHA in plasma phospholipids; preformed EPA was more effective. The proportion of EPA in platelet lipids increased in a dose dependent manner. EPA or DHA, but not ALA, decreased plasma triglyceride and VLDL cholesterol concentrations. Supplements containing DHA increased HDL and HDL2 cholesterol and LDL apoB. Total cholesterol and LDL cholesterol concentrations were unaltered.
In Vivo MRI Mapping of Brain Iron Deposition across the Adult Lifespan

Disruption of iron homeostasis as a consequence of aging is thought to cause iron levels to increase, potentially promoting oxidative cellular damage. Therefore, understanding how this process evolves through the lifespan could offer insights into both the aging process and the development of aging-related neurodegenerative brain diseases. This work aimed to map, in vivo for the first time with an unbiased whole-brain approach, age-related iron changes using quantitative susceptibility mapping (QSM)—a new postprocessed MRI contrast mechanism. To this end, a full QSM standardization routine was devised and a cohort of N = 116 healthy adults (20–79 years of age) was studied. The whole-brain and ROI analyses confirmed that the propensity of brain cells to accumulate excessive iron as a function of aging largely depends on their exact anatomical location. Whereas only patchy signs of iron scavenging were observed in white matter, strong, bilateral, and confluent QSM–age associations were identified in several deep-brain nuclei—chiefly the striatum and midbrain—and across motor, premotor, posterior insular, superior prefrontal, and cerebellar cortices. The validity of QSM as a suitable in vivo imaging technique with which to monitor iron dysregulation in the human brain was demonstrated by confirming age-related increases in several subcortical nuclei that are known to accumulate iron with age. The study indicated that, in addition to these structures, there is a predilection for iron accumulation in the frontal lobes, which when combined with the subcortical findings, suggests that iron accumulation with age predominantly affects brain regions concerned with motor/output functions. SIGNIFICANCE STATEMENT This study used a whole-brain imaging approach known as quantitative susceptibility mapping (QSM) to provide a novel insight into iron accumulation in the brain across the adult lifespan. Validity of the method was demonstrated by showing concordance with ROI analysis and prior knowledge of iron accumulation in subcortical nuclei. We discovered that, beyond these regions, there is extensive involvement of the frontal lobes that has been missed by past ROI analyses. Broadly speaking, therefore, the motor system selectively accumulates iron with age. The results offer insights into the aging process, but also offer a new approach to studying the role of iron dysregulation in the evolution of age-related neurodegenerative diseases.
Congenital adrenal hyperplasia due to steroid 21‐hydroxylase deficiency

Cortisol is normally synthesized from cholesterol in the zona fasciculata of the adrenal cortex in five successive enzymatic conversions (Fig. 1). Congenital adrenal hyperplasia (CAH), the inherited inability to synthesize cortisol, may be caused by defective importation of cholesterol into mitochondria (Lin et al., 1995; Boseet al., 1996) or, more commonly, by mutations in steroidogenic enzymes (reviewed in White, 1994a). More than 90% of cases are caused by a deficiency of the 21hydroxylase activity required to convert 17-hydroxyprogesterone to 11-deoxycortisol. This review will focus on our current knowledge of this disorder. Detailed reviews of other deficiencies causing CAH, including 11 b-hydroxylase (White & Speiser, 1994; Whiteet al., 1994b), 17a-hydroxylase (Yanaseet al., 1991; Yanase, 1995) and 3 b-hydroxysteroid dehydrogenase (Simard et al., 1995), have been published. In patients with 21-hydroxylase deficiency, poor synthesis of cortisol results in chronic stimulation of the adrenal cortex by corticotrophin with consequent overproduction of cortisol precursors. Some of these precursors are shunted into the androgen biosynthetic pathway causing signs and symptoms of androgen excess, including ambiguous genitalia in females and rapid somatic growth with accelerated skeletal maturation in both sexes. The disease occurs in a wide spectrum of clinical variants, including a severely affected form with a concurrent defect in aldosterone biosynthesis (‘salt wasting’ type), a form with apparently normal aldosterone biosynthesis (‘simple virilizing’ type) and a mild ‘non-classical’ form that may be asymptomatic or may be associated with signs of androgen excess developing during childhood or at puberty. The salt wasting and simple virilizing forms, collectively referred to as ‘classical’ 21-hydroxylase deficiency, occur in 1/10 000–1/15 000 births in most populations based on newborn screening studies. The frequency of the non-classical form is difficult to determine due to problems of ascertainment. It may be quite frequent in certain populations such as Jews of Eastern European origin (Speiser et al., 1985).
Current evidence for the management of rheumatoid arthritis with synthetic disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis

Objectives To assess the efficacy and safety of synthetic disease-modifying antirheumatic drugs (DMARDs) in adults with rheumatoid arthritis (RA)—a first step in a European League Against Rheumatism (EULAR) initiative to produce recommendations for the management of RA. Methods A systematic review of the literature using PubMed, Embase and the Cochrane library was performed up to January 2009. All randomised controlled trials (RCTs) reporting the efficacy of synthetic DMARDs (vs placebo or other synthetic DMARDs) on signs and symptoms, disability and/or radiographic structural damage in patients with RA were selected. Studies of biological agents or glucocorticoids were excluded. A pooled effect size (ES) was calculated by meta-analysis. Safety and the occurrence of infections and neoplasia was also assessed. Results 97 RCTs (14 159 patients) were analysed for efficacy. The pooled analysis indicated that methotrexate (MTX) was more efficacious in reducing signs and symptoms, disability and radiographic structural damage than other synthetic DMARDs pooled: ES for swollen joint count (SJC) versus pooled DMARDs=1.42 (95% CI 0.65 to 2.18). Leflunomide appeared to be as effective as MTX. Sulfasalazine and injectable gold were efficacious in reducing signs and symptoms and structural damage. Ciclosporin, minocycline, tacrolimus and hydroxychloroquine showed some efficacy in reducing SJC. Auranofin and D-penicillamine showed no significant superiority over placebo. The risks of cancer and of infection were increased with cyclophosphamide and azathioprine. Conclusions MTX was well-tolerated and effective in reducing signs and symptoms, disability and structural damage. A comparison with other synthetic DMARDs was in favour of MTX, though at the tested doses MTX and leflunomide were equally effective.
The Efficiency-Incentive Tradeoff in Double Auction Environments

We consider the tradeoff between efficiency and incentives in large double auction environments with weak budget balance. No mechanism simultaneously gives agents perfect incentives to be truthful and ensures first-best efficiency, but a planner designing a mechanism may be willing to compromise on either of these dimensions for improvements along the other. She would then naturally wish to find where the possibility frontier lies with respect to incentives and efficiency. We make inroads on this question: our main result locates the frontier to within a factor that is logarithmic in the size of the market. Thanks to (in random order) Alessandro Bonatti, Xiao Yu Wang, Ruitian Lang, Glenn Ellison, Parag Pathak, Rakesh Vohra, and Juuso Toikka for helpful comments and advice.
Opportunities for smartphones in clinical care: the future of mobile mood monitoring.

ACKNOWLEDGEMENTS & DISCLOSURE The Emotion Sense research was supported by the UK Engineering and Physical Sciences Research Council’s UBhave project (Ubiquitous and Social Computing for Positive Behaviour Change, Ref. EP/I032673/1); its open source software can be accessed via http://emotionsense.org/. Lathia, Mascolo, and Rentfrow have equity ownership in Emotion Sense Mobile Ltd., which is developing products related to the reported research.
CARRIER BASED PWM TECHNIQUE AND ADAPTIVE NEURAL NETWORK BASED ROTOR RESISTANCE ESTIMATOR FOR THE PERFORMANCE ENHANCEMENT OF VECTOR CONTROLLED INDUCTION MOTOR DRIVES

In this paper, the carrier based Pulse Width Modulation (PWM) technique and neural network based rotor resistance estimator are proposed for vector controller Induction motor (IM) drives. The popular sine PWM is used for induction motor drive. The popular sine PWM has poor harmonic profile and (DC) utilization. The space vector modulation (SVM) technique overcomes the disadvantages of sine PWM. But SVM is computationally complex. Hence a simple PWM technique namely “carrier based PWM technique” similar to SVM is identified and proposed for vector controlled IM drive. The experimental set up is built up and the performance of carrier based PWM is validated using FPGA processor. The adaptive neural network based rotor resistance estimator in predictive mode is proposed for the vector controlled induction motor drive. The performance enhancement of the drive with carrier based PWM and rotor resistance estimator is comprehensively presented.
“As Needed” Case Management Across Aging Services in Response to Depression

A lack of clarity on how and where case management for older adults is delivered persists, even as evidence supports its use to respond to depression. We used in-depth interviews with managers (n = 20) and staff surveys (n = 142) from 17 service agencies to explore the provision of case management services in adult day services, homecare, senior centers, and supportive housing. Limited case management services were found. Barriers included limited time and resources, especially for senior centers and supportive housing. Results revealed a concern about the role, feasibility, and availability of case management for older adults within these settings.
Trade Openness and Monetary Policy in Ghana

ABSTRACT The study employed a Structural VAR model, using monthly time series data from 2002 to 2017 to assess the relationship between trade openness and effectiveness of monetary policy in Ghana. The empirical results revealed that as the degree of trade openness increases, monetary policy becomes more effective in reducing the rate of inflation. However, monetary policy is less effective to reduce the output gap. Therefore, the results suggest that monetary policy authorities must take into account the level of trade openness whenever they are formulating monetary policy.
Management of a solitary thyroid nodule.

The solitary thyroid nodule, defined as a palpably discrete swelling within an otherwise apparently normal gland, is usually a benign lesion. However, patient and physician alike are typically concerned about the possibility of thyroid cancer. This review describes a strategy for the treatment of clinically euthyroid patients who have a solitary thyroid nodule that prevents unnecessary testing while identifying the few patients who require therapy. Management has changed in recent years, but important differences of opinion remain over which nodules should be surgically excised. Several recent reviews address these issues comprehensively1–3. Prevalence of Thyroid Nodules and Cancer The .
Identification of Parvovirus-Like Virus Particles in Intestinal Crypt Epithelial Cells of Pigs with Diarrhea

8and in Japan. 16 This communication presents morphologic evidence of a naturally occurring enteric infection of a nursing piglet by a parvovirus-like virus. In August 1988, specimens from 2 15-day-old nursing piglets from a 400-sow breeding herd located in northeast Nebraska were submitted by a local veterinarian to the Veterinary Diagnostic Center for laboratory examination. During the previous month, diarrhea had occurred in piglets 7-10 days of age, and morbidity and mortality were approximately 40% and 30%, respectively. Treatment had consisted of supportive oral fluid and antibiotic therapy. Pregnant animals had been vaccinated with a commercial product for prevention of swine colibacillosis and clostridial and rotavirus enteritis. Clinical signs of diarrhea and dehydration were seen in 1 piglet, and nervous signs and pneumonia were observed in the other. The 2 piglets were euthanized, and samples of heart, lung, liver, small intestine, spleen, and kidney were fixed in 10% buffered formalin. Samples of heart and small intestine were also submitted chilled on ice for diagnostic examination. Histopathologic examination of hematoxylin and eosin (HE)-stained sections of small intestine revealed severe diffuse necrosis of the cells of the crypts of Leberkuhn with collapse of the lamina propria and denudation of intestinal
iOS Anti-forensics: How Can We Securely Conceal, Delete and Insert Data?

With increasing popularity of smart mobile devices such as iOS devices, security and privacy concerns have emerged as a salient area of inquiry. A relatively under-studied area is anti-mobile forensics to prevent or inhibit forensic investigations. In this paper, we propose a "Concealment" technique to enhance the security of non-protected (Class D) data that is at rest on iOS devices, as well as a "Deletion" technique to reinforce data deletion from iOS devices. We also demonstrate how our "Insertion" technique can be used to insert data into iOS devices surreptitiously that would be hard to pick up in a forensic investigation.
BrainLab VectorVision Neuronavigation System: technology and clinical experiences in 131 cases.

OBJECTIVE The BrainLab VectorVision neuronavigation system was used in 131 cases of different brain pathological conditions. The neuronavigation system was used without problems in 125 cases. These cases included 114 microsurgical operations, 4 endoscopic procedures, 4 frameless stereotactic biopsies, and 3 catheter placements. METHODS The BrainLab VectorVision neuronavigation system is an intraoperative, image-guided, frameless, localization system. The system consists of a computer workstation for registration of images and physical spaces, an intraoperative localization device, and a computer image display. The system provides real-time responses regarding the locations of surgical instruments. VectorVision is based on passive reflections of infrared flashes. Universal adapters with reflective markers for surgical instruments, endoscopes, and the operating microscope are used. RESULTS In six cases, the system could not be used because of system failure or mishandling. In 125 neurosurgical cases, the neuronavigation system was useful, with a target-localizing accuracy of 4+/-1.4 mm (mean+/-standard deviation). For small cerebral lesions, we never performed an exploration with negative results. CONCLUSION The BrainLab neuronavigation system has been shown to be very helpful and user-friendly for routine neurosurgical interventions. Its advantage lies in its mobility, based on wireless reflective adapters for surgical instruments, endoscopes, and the operating microscope.
Changing-Look AGNs or Short-Lived Radio Sources?

The evolution of extragalactic radio sources has been a fundamental problem in the study of active galactic nuclei for many years. A standard evolutionary model has been created based on observations of a wide range of radio sources. In the general scenario of the evolution, the younger and smaller Gigahertz-Peaked Spectrum (GPS) and Compact Steep Spectrum (CSS) sources become large-scale FRI and FRII objects. However, a growing number of observations of low power radio sources suggests that the model cannot explain all their properties and there are still some aspects of the evolutionary path that remain unclear. There are indications, that some sources may be short-lived objects on timescales of $10^4$ - $10^5$ years. Those objects represent a new population of active galaxies. Here, we present the discovery of several radio transient sources on timescales of 5-20 years, largely associated with renewed AGN (Active Galactic Nucleus) activity. These changing-look AGNs possibly represent behaviour typical for many active galaxies.