Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of placement and restoration timing on single-implant esthetic outcome - a randomized clinical trial.

AIM The objective of this randomized clinical trial was to investigate the influence of the time of implant placement (immediate vs. early) and the time of restoration (immediate vs. early) on esthetic outcome in maxillary anterior single implants. MATERIAL AND METHODS Forty-eight patients with a single failing incisor in the maxilla and a natural contralateral site were randomly distributed into four groups. Treatment variations affected the time of implant placement (immediate or early) as well as the time of restoration (immediate or early) - in detail, group 1a with immediate implant placement and immediate temporary restoration, group 1b with immediate implant placement and early restoration, group 2a with early implant placement and immediate temporary restoration, and group 2b with early implant placement and early restoration. All patients received the final prosthetic restoration 10-12 weeks after implant placement. Standardized photographs were taken eight months after tooth extraction. Five competent observers analyzed the esthetic outcome according to the PES after Fürhauser. For statistical analysis, the Kruskal-Wallis test and Dunn's post hoc test were applied. Interobserver reliability was evaluated by Krippendorff's alpha. RESULTS The overall scores of the four treatment groups revealed PES values of 8.47 (SD 2.08, group 1a), 7.93 (SD 3.21, group 1b), 6.62 (SD 3.24, group 2a), and 8.10 (SD 3.25, group 2b). The differences between groups 2a and 1a and between groups 2a and 2b were statistically significant (P = 0.015 and P = 0.047). The single parameter analysis displayed a certain range of fluctuation and heterogeneity. CONCLUSIONS Immediate implant placement and restoration appear to be a viable alternative to early implant placement if an experienced surgeon is entrusted with the implantation procedure.
Ethnicity and the relationship of sodium intake to blood pressure

Objective To examine the impact of race on the relationship between sodium intake and blood pressure. Methods We examined the blood pressure levels and 24-h urinary sodium excretion of 808 (355 Black, 453 Caucasian) union members who participated in a workplace hypertension control program. The 808 study subjects, who met the criterion for accuracy of urine collection, included 627 untreated hypertensives (systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥95 mmHg, or both) and 181 normotensives (blood pressure <160/95 mmHg). Results In univariate analysis, the age-adjusted mean diastolic blood pressure levels of the Black subjects exceeded those of the Caucasian subjects at a significance level that was marginal for the male and very high for the female subjects. No differences were observed in mean systolic blood pressure between the Black and Caucasian subjects. Within each racial grouping, the subjects were grouped by sex-specific tertile of urinary sodium excretion in order to compare baseline characteristics and blood pressure levels. Small differences between the Black and Caucasian males in age-adjusted blood pressure within each urinary sodium excretion category were further diminished after adjusting for confounding factors. Significant differences between the Black and Caucasian females in age-adjusted diastolic blood pressure within each urinary sodium excretion group became non-significant when further adjusted for weight or body mass index, or both. These findings are in agreement with those observed in multiple linear regression models. Conclusion In this socio-economically homogeneous group, when confounding factors are considered, Black and Caucasian subjects have similar blood pressure levels at the same level of 24-h urinary sodium excretion. Ethnicity itself was not found to influence the relationship between sodium intake and blood pressure.
Thermal Comfort Assessment of a Classroom in Tropical Climate Conditions

Thermal comfort is the study of indoor comfort level feel by the occupant in a room. This paper presents the study of thermal comfort that had been carried out in a classroom on the second floor at a local school in Bandar Baru Bangi, Selangor, Malaysia. The study was made in 5 days from 2 pm to 6 pm. This study was carried out to assess their thermal conditions during the students’ lesson hours. Thermal comfort variables were measured during lesson hours too. Objective data analysis showed that none of the classes had thermal conditions falling within the comfort zone of ASHRAE standard 55. The result shows the environmental condition of the class is warm to hot in 7-point ASHRAE scale. The linear regression between Predicted Mean Vote and Operative Temperature reveals that the maximum acceptable temperature in this field of study is 26.5oC. Key-Words: Thermal Comfort, Field Study, PMV. PPD, Classroom, Tropical Climate
Utilización de los intereses, necesidades y conocimientos de los médicos de la familia como instrumento evaluativo de su práctica social

RESUMEN: Se realizo una investigacion operacional de campo acerca de la organizacion de los Sistemas Locales de Salud, asi como el desarrollo integral de los recursos humanos en esta esfera, para lo cual se aplicaron varios instrumentos de la practica epidemiologica, tales como: revision documental, encuestas, entrevistas, discusion grupal y otros, en los medicos de la familia del consejo popular "Los Olmos" perteneciente al Policlinico "Julian Grimau Garcia" en el municipio Santiago de Cuba. Se comprobo que las limitaciones mas importantes estaban dadas por la necesidad de definir y dirigir la atencion de la salud con un enfoque epidemiologico que integre los aspectos biomedicos con los sociales y psicologicos. Los problemas sociales se identificaron como fuente de trastornos de salud en la comunidad, pero los actores sociales no se hallaban suficientemente adiestrados para realizar acciones que conduzcan a su modificacion, a la vez que se ignora a la comunidad como via de solucion de sus propios problemas de salud.
DEVELOPMENT OF EPSTEIN-BARR VIRUS UVEITIS AFTER REMISSION OF PRIMARY VITREORETINAL LYMPHOMA.

PURPOSE To describe a case of Epstein-Barr virus (EBV) uveitis that occurred after the treatment and remission of primary vitreoretinal lymphoma (PVRL). METHODS Descriptive case report. Complete ophthalmologic evaluation, cytology, polymerase chain reaction, cytokine analysis of aqueous humor, and diagnostic vitrectomy were performed. RESULTS A 66-year-old Caucasian woman developed uveitis in the same eye 20 months after remission of PVRL. Empiric chemotherapy failed to treat the suspected PVRL recurrence, and aqueous humor cytology showed an absence of malignant cells. Qualitative polymerase chain reaction of aqueous humor confirmed the presence of EBV. Treatment for EBV resulted in remission of the uveitis. CONCLUSION The authors describe a rare case of EBV uveitis that was preceded by PVRL. It is important to consider EBV in cases where suspected recurrence of PVRL does not respond to appropriate treatment.
In vitro antileishmanial activity of fisetin flavonoid via inhibition of glutathione biosynthesis and arginase activity in Leishmania infantum

Abstract With the increasing emergence of drug resistant Leishmania sp. in recent years, combination therapy has been considered as a useful way to treat and control of Leishmaniasis. The present study was designed to evaluate the antileishmanial effects of the fisetin alone and combination of fisetin plus Meglumine antimoniate (Fi-MA) against Leishmania infantum. The IC50 values for fisetin were obtained 0.283 and 0.102 μM against promastigotes and amastigote forms, respectively. Meglumine antimoniate (MA, Glucantime) as control drug also revealed IC50 values of 0.247 and 0.105 μM for promastigotes and amastigotes of L. infantum, respectively. In order to determine the mode of action of fisetin and Meglumine antimoniate (MA, Glucantime), the activities of arginase (ARG), catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) were measured. Moreover, intracellular glutathione (GSH) and nitric oxide (NO) levels in L. infantum-infected macrophages and L. infantum promastigotes which were treated with IC50 concentrations of fisetin, MA and Fi-MA were investigated. Our results showed that MA decreased CAT and SOD activity and increased NO levels in L. infantum-infected macrophages. In promastigotes, MA inhibited parasite SOD activity and reduced parasite NO production. The decreased levels of most of the antioxidant enzymes, accompanying by the raised level of NO in treated macrophages with MA, were observed to regain their normal profiles due to Fi-MA treatment. Furthermore, fisetin could prevent the growth of promastigotes by inhibition of ARG activity and reduction of GSH levels and NO production. In conclusion, these findings showed that fisetin improves MA side effects.
Lateral Inhibition and Geometric Illusions

It has been suggested that lateral inhibitory processes, operating through the mutual inhibition and displacement of spatially adjacent contours imaged on the retina, may account for many of the classical geometric illusions. Two experiments were conducted, one using an alternative form of the Poggendorff illusion, and the other an alternative form of the Muller—Lyer, in which the adjacent contours necessary for the operation of the inhibitory mechanism were eliminated. In both instances the illusion was still found to exist, although somewhat reduced in magnitude. These results indicate that lateral inhibition may play a contributory role in illusion formation, but it is not the primary casual, mechanism.
A calibration method of workpiece frames for ultrasonic testing using twin-robot

A calibration method of workpiece frames using twin-robot is presented in this paper. Path planning for workpiece is based on its frame. Thus, the workpiece frames of two robots should be calibrated to make sure the motion of the twin-robot is under the same coordinate system. However, when twin-robot are separated from the workpiece, the twin-robot cannot reach some calibration points on workpiece at the same time. So a new method is proposed to solve the problem. The translation and rotation matrices between the base frames of two robots can be obtained by measuring the coordinate values of any three non-collinear points in working space. When only one robot can actually reach the calibration point of the workpiece frame, the coordinate value of this point in another robot base frame can be obtained by the matrices calculation. Experiment results show that the calibration method is relatively precision and convenient.
A Framework of Ontology Management System

Ontologies are emerging as a key solution to knowledge sharing, semantic retrieval, information exchange among heterogeneous systems, etc. An ontology management system (OMS), which supports building, using and maintaining of ontologies, and which provides a mechanism for querying ontologies and an easy-to-use programming interface to interact with them and their instances, is consequently witnessing in the areas. To promote research and development of OMS, this paper defines its general framework and functional modules according to that of a database management system (DBMS). And it analyzes each OMS sub-module in details while considering integrity of the whole system. An OMS is a powerful tool to create ontologies and expand the application, scope and quality of existing ones.
FGF Receptors: Cancer Biology and Therapeutics

Fibroblast growth factors (FGFs) are involved in a variety of cellular processes, such as stemness, proliferation, anti‐apoptosis, drug resistance, and angiogenesis. Here, FGF signaling network, cancer genetics/genomics of FGF receptors (FGFRs), and FGFR‐targeted therapeutics will be reviewed. FGF signaling to RAS‐MAPK branch and canonical WNT signaling cascade mutually regulate transcription programming. FGF signaling to PI3K‐AKT branch and Hedgehog, Notch, TGFβ, and noncanonical WNT signaling cascades regulate epithelial‐to‐mesenchymal transition (EMT) and invasion. Gene amplification of FGFR1 occurs in lung cancer and estrogen receptor (ER)‐positive breast cancer, and that of FGFR2 in diffuse‐type gastric cancer and triple‐negative breast cancer. Chromosomal translocation of FGFR1 occurs in the 8p11 myeloproliferative syndrome and alveolar rhabdomyosarcoma, as with FGFR3 in multiple myeloma and peripheral T‐cell lymphoma. FGFR1 and FGFR3 genes are fused to neighboring TACC1 and TACC3 genes, respectively, due to interstitial deletions in glioblastoma multiforme. Missense mutations of FGFR2 are found in endometrial uterine cancer and melanoma, and similar FGFR3 mutations in invasive bladder tumors, and FGFR4 mutations in rhabdomyosarcoma. Dovitinib, Ki23057, ponatinib, and AZD4547 are orally bioavailable FGFR inhibitors, which have demonstrated striking effects in preclinical model experiments. Dovitinib, ponatinib, and AZD4547 are currently in clinical trial as anticancer drugs. Because there are multiple mechanisms of actions for FGFR inhibitors to overcome drug resistance, FGFR‐targeted therapy is a promising strategy for the treatment of refractory cancer. Whole exome/transcriptome sequencing will be introduced to the clinical laboratory as the companion diagnostic platform facilitating patient selection for FGFR‐targeted therapeutics in the era of personalized medicine.
Hematological Effects, Serum, and Pulmonary Cytokine Profiles in a Melanoma Mouse Model Treated with GK1.

OBJECTIVE In a previous study, we demonstrated the therapeutic efficacy of a subcutaneous injection of GK1 peptide in a melanoma mouse model, effectively increasing the mean survival time by 42.58%, delaying tumor growth, and increasing intratumoral necrosis compared with the control. As a first approach to investigate the anti-melanoma effect of GK1, this study was carried out to determine the hematological effects along with both serum and lung cytokine profiles in a melanoma lung metastatic model. MATERIALS AND METHODS Thirteen C57BL6 female mice were transfected in the lateral tail vein with 2×10(5) B16-F0 melanoma cells. After 7 days, mice were separated in two different groups and treatments were initiated (day 0): The GK1-treated group (seven mice) were injected every 5 days intravenously with GK1 (10 μg) in the lateral tail vein, and the control group (six mice) were injected every 5 days with intravenous saline solution. Blood samples were collected every 5 days from day 0; tumor samples were obtained for cytokine measurements on the day of sacrifice. RESULTS In the peripheral blood, mice treated with GK1 presented a statistically significant decrease in IFN-γ (p<0.05), and lymphocytes tended to be lower compared with the control mice (p=0.06). Lung metastatic analysis demonstrated a significant increase in IFN-γ and IL-12p70 (p<0.05); a significant decrease in IL-17, IL-4, IL-22, IL-23, and IL-12p40 (p<0.05); and a marginal decrease in IL-1β (p=0.07) compared with the control. DISCUSSION Our results suggest that an intratumoral increase of cytokines with antitumor activity along with an intratumoral decrease of cytokines with protumor activity could explain, in part, the anti-melanoma effects of GK1 in a lung metastatic melanoma mouse model. Further studies must be performed to elucidate the precise mechanisms of action for GK1 peptide against melanoma, and their eventual application in humans.
Spectral Sequences from Sequences of Spectra : Towards the Spectrum of the Category of Spectra

As is well known, it is our manifest destiny as 21st century algebraic topologists to compute homotopy groups of spheres. This noble venture began even before the notion of homotopy was around. In 1931, Hopf was thinking about a map he had encountered in geometry from S to S and wondered whether or not it was essential. He proved that it was by considering the linking of the fibers. After Hurewicz developed the notion of higher homotopy groups this gave the first example, aside from the self-maps of spheres, of a non-trivial higher homotopy group. Hopf classified maps from S to S and found they were given in a manner similar to degree, generated by the Hopf map, so that
Antibacterial surfaces for biomedical devices

Despite considerable research and development efforts, the problem of infections related to biomedical devices and implants persists. Bacteria evidently can readily colonize surfaces of synthetic materials, such as those used for the fabrication of catheters, hip and knee implants, and many other devices. As the growing colony encapsulates itself with a protective exocellular bacterial polysaccharide layer, the biofilm becomes much harder to combat than circulating bacteria. Thus, there is a strong need to mitigate bacterial colonization by equipping the surfaces of biomedical devices and implants with features such as surface chemistry and surface roughness that are unfavorable for bacterial attachment. Here we review a number of strategies used for the design of antibacterial coatings. We also discuss specific issues that arise from using various types of coatings.
Determination of blood lead using a 4·0 mm paper punched disc carbon sampling cup technique

Cernik, A. A. (1974). British Journal of Industrial Medicine,31, 239-244. Determination of blood lead using a 4·0 mm paper punched disc carbon sampling cup technique. The method described is designed to overcome difficulties associated with presentation of the sample and its analysis for lead in blood. Chromium-51 studies on the effect of spread showed that imprecision resulted when discs of less than 4·0 mm diameter were punched from a given blood spot. The best standard deviation and relative standard deviation for increasing lead concentrations was obtained when 4·0 mm discs were used. Small daily voltage variations to the carbon cup workhead required that the non-specific absorption should be controlled to 0·02 absorbance at the ashing step. The occurrence of a second non-atomic signal was not considered significant since it had a different volatilization temperature to lead. Several advantages of the method are stated. A comparison of 4·0 mm against 6·5 mm punched discs was investigated using 33 samples of blood ranging from 9·0 to 126 μg of lead per 100 ml blood. Correlation (r = 0·970) and regression lines are shown. Absolute sensitivity of the method was 25 × 10-12 g.
Magnetic field canceling coil for wireless power transfer system

Wireless power transfer (WPT) technology is a promising approach to easily charging the batteries of electric vehicles and plug-in hybrid vehicles. WPT systems that use magnetic coupling generate a surrounding magnetic field, and it is beneficial to reduce this magnetic field from the viewpoint of electromagnetic compatibility. We propose a magnetic field reduction method using magnetic field canceling coils and conductive plates. This method can reduce the magnetic field far from the WPT system without reducing the coupling factor.
Decentralized Deep Reinforcement Learning for a Distributed and Adaptive Locomotion Controller of a Hexapod Robot

Locomotion is a prime example for adaptive behavior in animals and biological control principles have inspired control architectures for legged robots. While machine learning has been successfully applied to many tasks in recent years, Deep Reinforcement Learning approaches still appear to struggle when applied to real world robots in continuous control tasks and in particular do not appear as robust solutions that can handle uncertainties well. Therefore, there is a new interest in incorporating biological principles into such learning architectures. While inducing a hierarchical organization as found in motor control has shown already some success, we here propose a decentralized organization as found in insect motor control for coordination of different legs. A decentralized and distributed architecture is introduced on a simulated hexapod robot and the details of the controller are learned through Deep Reinforcement Learning. We first show that such a concurrent local structure is able to learn better walking behavior. Secondly, that the simpler organization is learned faster compared to holistic approaches.
Risk Factors Associated With Pterygium and Its Subtypes in Korea: The Korean National Health and Nutrition Examination Survey 2008–2010

Purpose: To assess the sociodemographic and health-related risk factors associated with pterygium and its subtypes in Korea. Methods: From 2008 to 2010, a total of 14,920 randomly selected national representative participants of the Korean National Health and Nutrition Examination Survey underwent additional ophthalmologic examinations by the Korean Ophthalmologic Society. The risk factors for pterygium in general or according to subtype (atrophic, intermediate, and fleshy) were identified using multivariate logistic regression analysis. Results: The prevalence of pterygium was 6.7% (95% confidence interval, 5.9–7.5) in subjects aged 30 years or older. Older age, male sex, lower educational level, rural habitation, nonsmoking, and sun exposure were independent risk factors for pterygium. Among subjects with pterygium, older age, male sex, lower educational level, and nonsmoking were independent risk factors for all types of pterygium. Sun exposure for >5 h/d was the independent risk factor for the severe pterygium subtype. Conclusions: Socioeconomic disparities in pterygium development exist. Proper ocular examination and education to avoid excessive sun exposure would be helpful in reducing disease risk.
SODA: Detecting COVID-19 in Chest X-Rays With Semi-Supervised Open Set Domain Adaptation

Due to the shortage of COVID-19 viral testing kits, radiology imaging is used to complement the screening process. Deep learning based methods are promising in automatically detecting COVID-19 disease in chest x-ray images. Most of these works first train a Convolutional Neural Network (CNN) on an existing large-scale chest x-ray image dataset and then fine-tune the model on the newly collected COVID-19 chest x-ray dataset, often at a much smaller scale. However, simple fine-tuning may lead to poor performance for the CNN model due to two issues, first the large domain shift present in chest x-ray datasets and second the relatively small scale of the COVID-19 chest x-ray dataset. In an attempt to address these two important issues, we formulate the problem of COVID-19 chest x-ray image classification in a semi-supervised open set domain adaptation setting and propose a novel domain adaptation method, Semi-supervised Open set Domain Adversarial network (SODA). SODA is designed to align the data distributions across different domains in the general domain space and also in the common subspace of source and target data. In our experiments, SODA achieves a leading classification performance compared with recent state-of-the-art models in separating COVID-19 with common pneumonia. We also present initial results showing that SODA can produce better pathology localizations in the chest x-rays.
Bound-vector solitary waves in isotropic nonlinear dispersive media.

On the basis of a simple analysis of the coupled nonlinear Schrodinger equations that govern pulse propagation in isotropic nonlinear dispersive media, we show the existence of a novel class of bound-vector solitary waves. These solitary waves are novel in exhibiting elliptical polarization that varies across the pulse and evolves periodically during propagation while the pulse intensity envelope remains unchanged. Simple physical arguments allow us to understand the existence and the features of these particular solutions.