Miracle-dz/UniFAR-FTUs huggingface dataset:
Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments.

Fibronectin has been shown previously to promote complete cell adhesion in the absence of other serum components or de novo protein synthesis. Recently a sequence of four amino acids from the cell‐binding domain of fibronectin has been termed the ‘cell recognition site’ of this multidomain molecule since it mediates cell attachment and inhibits cell adhesion to intact fibronectin. We show here, however, that substrata coated with an isolated cell‐binding domain of fibronectin are not sufficient for complete cell adhesion; cells attach and spread but, unlike those adhering to intact fibronectin, they do not form stress fibres terminating in focal adhesions. An additional external stimulus is needed for this cytoskeletal reorganisation and may be provided by one of two heparin‐binding fragments of fibronectin. The two ‘signals’ required for complete adhesion need not be provided simultaneously since focal adhesion formation can be promoted by stimulating cells pre‐spread on a cell‐binding fragment of fibronectin with a soluble heparin‐binding fragment. This second stimulation may involve cell membrane heparan sulphate proteoglycans.
The transcriptional repression of the human Cu/Zn superoxide dismutase(sod1) gene by the aticancer drugg, mitocycin C(MMC)

The Cu/Zn superoxide dismutase(sod1) is one of the key enzymes that protects cells against oxidative stress. In order to investigate the effects of mitomycin C(MMC) on the induction of apoptotic cell death and on the sod1 transcription level, the CATs activity of HepG2 cells transfected with sod1 promoter‐CAT(chloramphenicol acetyl transferase) fusion reporter was measured after MMC treatment. The CAT assay showed that exposure of HepG2 cells to MMC decreased the transcription level of the sod1 gene. The accumulation of p53 tumor suppressor protein by MMC treatment of HepG2 cells was noted. In order to investigate the p53‐negative response element in its promoter region, a p53 cotransfection experiment with serially deleted sod1 promoter/CAT reporter constructs was performed. The results show a significant reduction of CAT activity in all deletion reporter constructs. The results show that MMC treatment inhibited sod1 gene transcription through p53‐mediated transcriptional repression.
Trend Analysis in Harper’s Bazaar

Topic modeling of fashion trends were analyzed using the MALLET toolkit. Harper’s Bazaar magazines from 1860-1899 were used (freely available online). This resulted in 20 topics with 4 characterizing words each. Trends over time were analyzed in several different ways using 100-topics and 20-topics.
Development of the WHO Classification of Tumors of the Central Nervous System: A Historical Perspective

The classification of brain tumors has undergone numerous changes over the past half century. The World Health Organization has played a key role in the effort. Four versions of its Classification of Tumours of the Central Nervous System have been published. The present work chronicles their progress, placing emphasis on the historical context of the earliest effort.
Numerical and structural chromosome aberrations induced by etoposide (VP16) during oocyte maturation of mice: transmission to one-cell zygotes and damage to dictyate oocytes.

The antineoplastic drug etoposide (ET) inhibits topoisomerase II (topo II) activity by forming a ternary complex (DNA-ET-topo II). This complex prevents the DNA-strand-rejoining activity of topo II and may result in structural chromosome aberrations. Inhibition of topo II activity may also predispose cells to aneuploidy because this enzyme is needed for removing regions of DNA catenation prior to chromosome segregation. Our objectives were to study the dose response for ET-induced numerical and structural chromosomal aberrations in mouse one-cell zygotes, to compare these data with those obtained from a contemporary metaphase II (MII) oocyte study and to evaluate the sensitivity of dictyate oocytes to ET-induced aneuploidy. ICR female mice were superovulated and injected i.p. with either 6% dimethylsulphoxide (controls) or 20, 40 or 60 mg/kg ET 2 h after human chorionic gonadotrophin (HCG). ICR males were paired (1:1) with females immediately after treatment. After 17 h the males were removed, and after 24 h the females with a vaginal plug were given colchicine. One-cell zygotes were harvested for cytogenetic analysis 17 h after colchicine. The percentages of hyperploid zygotes were 1.1, 5.7, 13.8 and 20.7 and of zygotes with structural aberrations were 2.5, 16.3, 37.7 and 64.7, for control, 20, 40 and 60 mg/kg ET respectively. The differences between each succeeding dose for both structural and numerical aberrations were statistically significant (P < 0.01). When the ET dose response aneuploidy data from zygotes were compared with similar data from a contemporary study involving metaphase II oocytes, the frequencies of hyperploidy were greater in zygotes than in oocytes. We conclude that when ET is administered during the preovulatory phase of meiosis, it is both an aneugen and a clastogen in mouse one-cell zygotes.
Estudio y Modelado de una Red de Distribución de Contenido

� Abstract—Las redes de distribucion de contenido (CDN, Content Delivery Networks) surgieron a finales de los anos 90 como un medio de reducir el tiempo de respuesta experimentado por los usuarios de Internet al disponer multiples servidores de una forma distribuida y en las cercanias de los clientes. Numerosas companias han desplegado su propia CDN, pero esconden ciertos aspectos y detalles de su implementacion interna, por lo que surge la necesidad de un modelo general que describa el comportamiento de una CDN desde un punto de vista analitico. En este articulo se propone una expresion general de una red de distribucion de contenido asi como el impacto en el rendimiento del sistema atendiendo a diferentes parametros de diseno como la tasa de acierto, la latencia de red, el numero de servidores y la capacidad de estos.
Power Efficiency Improvements for Wireless Transmissions

To my parents, and my wife Lin Sun. iii ACKNOWLEDGEMENTS I would like to express my gratitude to all whose direct and indirect support helped me complete my thesis. First, I would like to thank my advisor, Prof. G. Tong Zhou who has continuously supported my work and ideas throughout my studies at Georgia Institute of Technology. I appreciate her close guidance and great efforts to prepare me to become a mature researcher.
Recurrent Rhabdomyolysis in a Teenager With Psychosis-Intermittent Hyponatremia-Polydipsia Syndrome

Objective To report a case of recurrent hyponatremia and rhabdomyolysis in a teenager with psychogenic polydipsia. Case Summary A 16-year-old boy was admitted with recurrent episodes of hyponatremia and rhabdomyolysis secondary to psychogenic polydipsia. He was treated with hypertonic saline, intravenous fluids, and supportive care. Discussion Psychogenic polydipsia is a condition characterized by compulsive drinking. Severe hyponatremia is a rare, but serious complication in patients with psychogenic polydipsia. Failure in cell volume regulatory mechanisms, defective osmoregulation, defective urinary dilution, and enhanced secretion of vasopressin are believed to play a role in the development of hyponatremia. Rhabdomyolysis can complicate severe hyponatremia, although the exact mechanism is not known. Antipsychotic drugs are also implicated in rhabdomyolysis. Conclusions Severe hyponatremia and rhabdomyolysis can complicate psychogenic polydipsia. Patients receiving antipsychotic drugs with concomitant severe hyponatremia need to be monitored for rhabdomyolysis.
THE EFFECT OF TUBOCURARINE COMPETITION ON THE KINETICS OF AGONIST ACTION ON THE NICOTINIC RECEPTOR

1 The rates at which tubocurarine associates with, and dissociates from, the nicotinic receptor, while exerting its classical competitive effect, are still in doubt. We have investigated this problem by observing the effect of low concentrations of tubocurarine on the re‐equilibration rate, following a step change in membrane potential, of the current produced by carbachol in voltage‐clamped endplates of frog muscle. 2 It is expected, and observed, that in order to see the effects of competition (as opposed to ion channel block), sufficiently high agonist concentrations must be used so that the relaxation rate becomes faster than that seen at low agonist concentrations. 3 Small concentrations of tubocurarine were found to reduce this relaxation rate, towards a value appropriate to a lower agonist concentration. 4 The results suggest that tubocurarine equilibrates very rapidly with the nicotinic receptor. 5 Some of the possible technical problems of this sort of experiment are discussed. The results are similar to those already published for nicotinic receptors in eel electric tissue.
Quantization based adaptive control of SPV-grid tied system

This paper applies a quantization based adaptive algorithm for an implementation of a three phase grid tied solar photovoltaic (SPV) system. This system also provides harmonics elimination and power factor correction (PFC) and thus it maintains an IEEE-519 standard by keeping the harmonics distortion of grid currents below 5%. For successfully extracting the maximum power from the SPV array at varying environmental conditions, a single stage system with P&O (Perturb and Observe) method is used, which is integrated with the quantization based adaptive control for the estimation of reference grid currents. Experimental results of the system performance are demonstrated to validate the design and control algorithm.
An fMRI study of simple ethical decision-making

Recent functional neuroimaging studies suggest that ventromedial prefrontal cortex (vmPFC), left posterior superior temporal sulcus (pSTS) and posterior cingulate cortex are engaged during moral decision-making on complex dilemmatic or salient emotional stimuli. In this fMRI study we investigated which of these brain regions are activated during simple ethical decision-making about unambiguous scenarios not containing direct bodily harm or violence. Simple moral decisions compared to semantic decisions resulted in activation of left pSTS and middle temporal gyrus, bilateral temporal poles, left lateral PFC and bilateral vmPFC. These results suggest that pSTS and vmPFC are a common neuronal substrate of decision-making about complex ethical dilemmas, processing material evocative of moral emotions and simple ethical decision-making about scenarios devoid of violence and direct bodily harm.
Análisis de los procesos de apropiación de derechos en un programa de inclusión social dirigido a jóvenes de sectores populares.

Este trabajo analiza con cierta profundidad algunos aspectos del trabajo de un programa de prevencion social del delito que trabaja con jovenes residentes en una villa de emergencia y cuyo principal abordaje consiste en las estrategias de inclusion social. En particular, nos detendremos en el analisis de los talleres y distintos dispositivos que el programa implementa para la ensenanza y transmision de derechos. Analizaremos los modos en los que estas ensenanzas son apropiadas y resignificadas por los jovenes beneficiarios. Del mismo modo, procuraremos estudiar como recibe el programa estatal las demandas espontaneas de ciertos derechos por parte de los jovenes. Este trabajo es producto de un trabajo de campo de caracter etnografico realizado a lo lagdo de dos anos.
Design and Characterization of Enhanced Angle Sensitive Pixels

Stacks of metal gratings placed above a photodiode have been demonstrated to show a strong sinusoidal response to angle. Although these devices, called angle sensitive pixels (ASPs), enable new imaging modalities on CMOS, such as light field capture, their optical sensitivity is limited by the metallic gratings. In this paper, we provide a detailed characterization of the angular response of ASPs and report on a new set of optically efficient structures for angle detection. By analyzing the properties of the Talbot effect, we present a quantitative model for the angular sensitivity, β, of an ASP and qualitatively describe the dependence of modulation depth, m, on the grating parameters. We then describe structures that employ phase gratings and interleaved diffusion diodes to provide angle sensitivity while improving the quantum efficiency by 4×. A post-CMOS process flow for the fabrication of phase gratings is described. Finally, we show that ASPs that use p+ diffusion diodes embedded in an n-well diode improve their modulation efficiency by over 50% compared with interleaved diodes that share the p-substrate.
A Serious Game to Improve Students' Skills in Global Software Development

In recent years, companies have been forced to change their business model, due to the phenomenon of globalization. Software development companies are no exception, and have attempted to join the global market so as to be able to hire labor in other countries, seeking to reduce costs, increase productivity and gain competitive advantages. This is known as Global Software Development (GSD). To perform this practice, companies require developers who possess knowledge and skills for solving problems that arise due to geographical, temporal and cultural distance. Traditional methods for teaching students or employees how to work in GSD environments are usually expensive, and require much effort. This is where serious games can play a key role, as they are educational games that allow for the acquisition of knowledge and skills at a low cost. This article presents a serious game with which some of the competencies needed in GSD can be acquired. The game simulates scenarios that usually occur in the overall development of a software project, so that the user can become aware of the problems concerning GSD and gain some experience in solving these problems.
THE CLINICAL CLASSIFICATION OF PULMONARY TUBERCULOSIS.

conclusions the impression that all distress in allergy. processes, as they are encountered in chronic tuberculosis, are not totally different processes, as would be required in order to make them bases of types into which tuberculosis is to be divided. On the contrary, as we meet them, either in primary tubercle or in the early re-inoculations, whether caused by bacilli escaping from foci in which they have been confined within the body of the host or by bacilli entering from without, or in the course of clinical tuberculosis, they represent different phases of the same tissue reaction to bacil- lary invasion. The difference in the degree of reaction varies with the degree of specific resistance present and the dosage of bacilli; a few bacilli causing a slight hyperemia with little exudation and the pro- liferation of fixed cells; while many cause severe in-flammatory and exudative phenomena. "
Comportamento dos preços no Brasil: evidênCias Utilizando miCrodados de preços ao ConsUmidor*

Utilizando uma base de microdados inedita, este trabalho apresenta as principais caracteristicas do comportamento de precos individuais para a economia brasileira. Acima de todas as economias ja analisadas, o Brasil possui uma frequencia mediana de variacao de precos de 54,8%, o que implica, pela mensuracao indireta, uma duracao de 1,3 mes. Assim como as evidencias internacionais: i) o comportamento dos precos entre os produtos e heterogeneo; ii) nao ha evidencia de rigidez para baixo nos precos; e iii) as variacoes individuais de precos sao de grande magnitude se comparadas aos resultados agregados. 1 introdUcAo O comportamento dos precos individuais acarreta uma serie de desdobramentos cujos impactos teoricos sao amplamente debatidos na literatura, mas cujas evidencias empiricas ainda carecem de maior investigacao. A falta de compreensao sobre o comportamento individual dos precos da margem a distintas abordagens para a analise de aspectos que vao desde a velocidade e intensidade de transmissao da politica monetaria aos movimentos da taxa de câmbio real. Alem disso, podemos ainda mencionar que o melhor entendimento da estrategia de price setting das firmas levaria ao aprimoramento da modelagem teorica, cujas abordagens e conclusoes podem sofrer alteracoes expressivas na presenca de fatos estilizados constatados pela literatura empirica. A ausencia de estudos que pudessem apresentar empiricamente um diagnostico do processo de definicao e o grau de rigidez de precos nos paises deveu-se menos a relevância do tema e mais a indisponibilidade de informacoes estatisticas no nivel de microdados que pudessem servir de base para estas analises. Ha ate bem pouco tempo os dados disponiveis permitiam apenas a realizacao de estudos pontuais, concentrados em mercados especificos, nao havendo possibilidade de realizar analises generalizadas aos diversos setores da economia. 1 Estes, por sua vez, apontavam para a existencia de uma rigidez de precos elevada, onde, em media, os precos se modificavam a cada 12 meses. * Os autores agradecem a equipe do Instituto Brasileiro de Economia da Fundacao Getulio Vargas (Ibre/FGV), em especial a Andre Furtado Braz e Joao Luis Ferreira Chaves o apoio metodologico e computacional. Os autores tambem agradecem os comentarios e sugestoes de dois pareceristas anonimos. Os erros remanescentes sao de responsabilidade dos autores e as opinioes expressas nao refletem as posicoes da FGV ou do Ibre.
Analysis of an Optically Injected Semiconductor Laser for Microwave Generation

The nonlinear dynamical period-one oscillation of an optically injected semiconductor laser is investigated analytically. The oscillation is commonly observed when the injection is moderately strong and positively detuned from the Hopf bifurcation boundary. The laser emits continuous-wave optical signal with periodic intensity oscillation. Since the oscillation frequency is widely tunable beyond the relaxation oscillation frequency, the system can be regarded as a high-speed photonic microwave source. In this paper, analytical solution of the oscillation is presented for the first time. By applying a two-wavelength approximation to the rate equations, we obtain mathematical expressions that characterize the oscillation. The analysis explains the physical origin of the periodic intensity oscillation as the beating between two wavelengths, namely, the injected wavelength and the cavity resonance wavelength. As the injection strength increases, the optical gain reduces, the cavity is red-shifted through the antiguidance effect, and so the beat frequency increases continuously. The theoretical analysis is useful for designing the system for photonic microwave applications.
Fall Detector with Random Classifier Optimization

Fall accidents are one of the main causes of injuries and accidental deaths for elder people. Automated fall detectors can be helpful for detecting the accident and sending an emergency call. For this purpose, a wearable fall detector device was developed, which served to collect a training set and to test certain classifiers. The current approach uses a random search algorithm to optimize a given model for discrimination of fall events from activities of daily living by measuring tri-axial accelerometer data. In the current state the device is able to recognize significant falls and can trigger an emergency call over mobile networks.
The Distribution of Antarctic Marine Benthic Communities

The Polar Frontal Zone, although predominantly a surface feature, forms a natural northernmost boundary for defining the Southern Ocean, and relatively few benthic organisms have distributions which cross this boundary. Many Antarctic benthic plants and animals have circumpolar distributions but some broad geographical subdivisions may be made. Detailed studies of community distribution are few in Antarctica, but heterogeneity has been demonstrated on all spatial scales. The Southern Ocean has a rich fauna compared with the much younger Arctic basin, and there is no convincing evidence either for or against a universallatitudinal cline in diversity in the southern hemisphere to match that well described from the northern hemisphere. Shallow water distributions are strongly affected by ice-related processes, and this leads to a strong vertical zonation in the biological assemblages of sublittoral habitats.
OCT angiography in the management of choroidal neovascular membrane secondary to Sorsby fundus dystrophy

We describe the management of a woman aged 52 years with molecularly confirmed Sorsby fundus dystrophy, who presented with acute visual deterioration in her right eye. Fundus examination identified a right macular lesion suggestive of a choroidal neovascular membrane (CNVM). Optical coherence tomography angiography (OCTA) confirmed the presence of a CNVM. She was treated with 2 monthly intravitreal injections of bevacizumab, associated with OCTA evidence of regression of the CNVM and improvement in her visual acuity. OCTA is a novel, non-invasive method of imaging the retinal vasculature. Images are acquired rapidly, with no associated side effects, offering advantages over the current gold standard technique—fundus fluorescein angiography.
CityGML – 3D City Models and their Potential for Emergency Response

Virtual 3D city models provide important information for different aspects of disaster management. In order to ensure the unambiguous interpretation of the represented objects, an ontology in the sense of a common information model for urban and regional structures has to be defined. Furthermore, up-to-dateness of and flexible access to 3D city models are of utmost importance. Spatial Data Infrastructures (SDI) provide the appropriate framework to cover this aspect, integrating distributed data sources on demand. In this chapter we present CityGML, which is in the first place an ontology for the three-dimensional, multi-purpose, and multi-scale representation of cities, sites, and regions. The implementation of CityGML is based on the standard GML3 of the Open Geospatial Consortium and thus defines an exchange format for the storage of and interoperable access to 3D city models in SDIs. The class taxonomy distinguishes between buildings and other man-made artifacts, vegetation objects, water bodies, and transportation facilities like streets and railways. Spatial as well as semantic properties are structured in five consecutive levels of detail. Throughout this chapter, special focus is on the utilization of model concepts with respect to different tasks in the context of emergency response.
TCP-CDR: An End-to-End Scheme for TCP Over Mobile Ad hoc Networks

In this paper, we present an end-to-end scheme, named as TCP-CDR, for the performance improvement of TCP over mobile ad hoc networks. This scheme combines congestion window limit, delayed ACK and maximum RTO limit. The comparisons between TCP-CDR and state-of-the-art end-to-end TCP schemes, including Newreno, FeW, TCP-AP, TCP-CD (CWL and Delayed ACK), show that both in static multihops wireless network and in mobile ad hoc networks, the TCP-CDR has the best goodput performance. In particular, different with the previous works, we generate the mobile scenarios not only using Random Waypoint mobility model but also social network mobility model
An Edge Detection Technique Using the Facet Model and Parameterized Relaxation Labeling

We present a method for detecting and labeling the edge structures in digital gray-scale images in two distinct stages: First, a variant of the cubic facet model is applied to detect the location, orientation and curvature of the putative edge points. Next, a relaxation labeling network is used to reinforce meaningful edge structures and suppress noisy edges. Each node label of this network is a 3D vector parameterizing the orientation and curvature information of the corresponding edge point. A hysteresis step in the relaxation process maximizes connected contours. For certain types of images, prefiltering by adaptive smoothing improves robustness against noise and spatial blurring.