Miracle-dz/UniFAR-FTUs huggingface dataset:
Advances in Brief Promoter Hypermethylation Patterns of p 16 , O 6-Methylguanine-DNA-methyltransferase , and Death-associated Protein Kinase in Tumors and Saliva of Head and Neck Cancer Patients 1

Aberrant promoter hypermethylation is common in head and neck cancer and may be useful as a marker for cancer cells. We examined whether cells with tumor-specific aberrant DNA-methylation might be found in the saliva of affected patients. We tested 30 patients with primary head and neck tumors using methylation-specific PCR searching for promoter hypermethylation of the tumor suppressor genep16(CDKN2A), the DNA repair gene O-methylguanine-DNA-methyltransferase(MGMT) and the putative metastasis suppressor gene death-associated protein kinase (DAP-K). Aberrant methylation of at least one of these genes was detected in 17 (56%) of 30 head and neck primary tumors; 14 (47%) of 30 at p16, 10 (33%) of 30 atDap-K and 7 (23%) of 30 atMGMT. In 11 (65%) of 17 methylated primary tumors abnormal methylated DNA was detected in the matched saliva samples. Abnormal promoter methylation in saliva DNA was found in all tumor stages and more frequently in tumors located in the oral cavity. Moreover, none of the saliva from patients with methylation-negative tumors displayed methylation of any marker. Of 30 saliva samples from healthy control subjects (15 smokers and 15 nonsmokers), only one sample from a smoking patient was positive for DNA methylation at two target genes. Detection of aberrant promoter hypermethylation patterns of cancer-related genes in saliva of head and cancer patients is feasible and may be potentially useful for detecting and monitoring disease recurrence. Long-term longitudinal studies are needed to evaluate this approach for early detection of head and neck cancer in at-risk populations.
Locations on time-varying networks

: We begin by examining the dynamic behavior of a facility location such as a 1-median or a 1-center on a network when the parameters of the network are known functions of time. The parameters of the network include the lengths of the edges and the demands at the nodes. In our formulation, time is considered a discrete variable and it is assumed that the facility can only serve customers while it is stationary and that the demands at time t are fully satisﬁed before time t 1 1. In particular, if x ( t ) denotes the location of the facility for t 5 1, 2, . , the cost would be the sum of the costs of satisfying the demands at the various times plus the cost of moving the facility along its route implied by x ( t ). We also examine certain path (route) selection problems in dynamic networks. Recent past literature is surveyed. Various extensions including the multifacility versions of the above problems are studied. © 1999 John Wiley & Sons, Inc. Networks 34: 250–257, 1999
THE GUILLAIN‐BARRÉ SYNDROME: THREE CASES IN ABORIGINAL NATIVES

I have pleasure in acknowledging my indebtedness to Dr. Hugh Ryan, who followed up the cases in series I, and to whom I am also indebted for the diagnosis in the cases, as well as for his research into the eye condition; to Dr. Adelaide Gault, who followed up and diagnosed the cases in series II; to Dr. Kevin O'Day, for his helpful demonstrations of the ocular structures; to Sister Guscott, in institution I, and Sister Price, in institution II, for their willing and unflagging cooperation; and to my obstetric colleagues for their interest and consideration.
The Medical Complications of Anorexia Nervosa

The physical complications of anorexia nervosa are common and can be life threatening, but psychiatrists and the increasing number of non-medical therapists involved in treatment programmes often overlook these complications. Cardiovascular complications are the most common, and the most likely to result in fatalities, particularly in those patients who vomit, purge or abuse diuretics, because of the electrolyte abnormalities induced. Osteoporosis is an early and perhaps irreversible consequence of severe weight loss. Further, there are dangers in rapid intravenous hyperalimentation.
Participating mortgages and the e ciency of financial intermediation I

This paper establishes a basic framework to study three di erent variants of Participating Mort- gages (PMs). We obtain results for Shared Appreciation (SAMs), Shared Income (SIMs) and shared Equity Mortgages (SEMs) in closed-form. We illustrate our findings with examples that show PMs are also attractive in an environment where prepayment can occur. Finally we conclude with the public policy implications of employing PMs as workout loans, especially post sub-prime crisis. We argue that by facilitating better risk sharing, PMs o er a means to enhance the e ciency and resiliency of the financial system.
The Phagocytosis-Associated Respiratory Burst in Human Monocytes Is Associated with Increased Uptake of Glutathione1

During the phagocytic respiratory burst, oxygen is converted to potent cytotoxic oxidants. Monocytes and macrophages are potentially long-lived, and we have hypothesized that protective mechanisms against oxidant stress are varied and fully expressed in these cells. We report here that the respiratory burst in monocytes is accompanied by an increase in the uptake of [35S]glutathione ([35S]GSH) after 20–30 min to levels up to 10-fold greater than those at baseline. By 30 min, 49% of the cell-associated radioactivity was in the cytosol, 41% was in membrane, and 10% was associated with the nuclear fraction. GSH uptake was inhibited by catalase, which removes hydrogen peroxide (H2O2), and micromolar H2O2 stimulated GSH uptake effectively in monocytes and also lymphocytes. Oxidation of GSH to glutathione disulfide with H2O2 and glutathione peroxidase prevented uptake. Acivicin, which inhibits GSH breakdown by γ-glutamyl transpeptidase (GGT), had no effect on the enhanced uptake seen during the respiratory burst. Uptake of cysteine or cystine, possible products of GGT activity, stayed the same or decreased during the respiratory burst. These results suggest that a GGT-independent mechanism is responsible for the enhanced GSH uptake seen during the respiratory burst. We describe here a sodium-independent, methionine-inhibitable transport system with a Km (8.5 μM) for GSH approximating the plasma GSH concentration. These results suggest that monocytes have a specific GSH transporter that is triggered by the release of H2O2 during the respiratory burst and that induces the uptake of GSH into the cell. Such a mechanism has the potential to protect the phagocyte against oxidant damage.
Intertemporal Consumption Choices, Transaction Costs and Limited Participation in Financial Markets: Reconciling Data and Theory

This paper builds a unifying framework based on the theory of intertemporal consumption choices that brings together the limited participation-based explanation of the C-CAPM poor empirical performance and the transaction costs-based explanation of incomplete portfolios. Using the implications of the consumption model and observed household consumption and portfolio choices, we identify the preference parameters of interest and a lower bound for the costs rationalizing non-participation in financial markets Assuming isoelastic preferences, we estimate the coefficient of relative risk aversion at 1.7 and a cost bound of 0.4 percent of non-durable consumption. Our estimate of the preference parameter is theoretically plausible and the bound sufficiently small to be likely to be exceeded by the actual total (observable and unobservable) costs of participating in financial markets.
Marketing Management Bases for International Market Segmentation: An Alternate Look at the Standardization/Customization Debate

By standardizing the marketing effort over similar worldwide segments and differentiating it across dissimilar worldwide segments, the international marketing manager is able to reap the advantages of both standardization and customization. The choice of the variables by which to segment the global market is crucial. Traditionally, purely environmental bases (geographic, political, economic, and cultural) were used as bases for international market segmentation. Proposes that international marketers group relevant markets based on both environmental as well as marketing management bases. The marketing management bases are classified as: (1) product‐related; (2) promotion‐related; (3) price‐related; and (4) distribution‐related. Derives number of propositions with direct implications for international marketing strategy and segmentation with respect to these bases. Highlights the managerial implications of the variables encompassed by these bases. Proposes the empirical investigation of the derived proposi.
Development path and dynamic capability of EMS company in far east region

This paper seeks to understand electronics manufacturing service providing (EMS) company's dynamic capability through the study of its development paths. We adopt case study as research methodology to understand company's daily operations. The result shows that EMS companies develop themselves through continuously acquiring and utilizing resources to build up new capabilities. Thus dynamic capability plays a key role in EMS company's growing up and development. The research delivers an exploratory view of the EMS company's manufacturing system and contributes to empirical research of dynamic capability.
Three new small nucleolar RNAs that are psoralen cross-linked in vivo to unique regions of pre-rRNA

We have recently described three novel human small nucleolar RNA species with unique nucleotide sequences, which were named E1, E2, and E3. The present article describes specific psoralen photocross-linking in whole HeLa cells of E1, E2, and E3 RNAs to nucleolar pre-rRNA. These small RNAs were cross-linked to different sections of pre-rRNA. E1 RNA was cross-linked to two segments of nucleolar pre-rRNA; one was within residues 697 to 1163 of the 5' external transcribed spacer, and the other one was between nucleotides 664 and 1021 of the 18S rRNA sequence. E2 RNA was cross-linked to a region within residues 3282 to 3667 of the 28S rRNA sequence. E3 RNA was cross-linked to a sequence between positions 1021 and 1639 of the 18S rRNA sequence. Primer extension analysis located psoralen adducts in E1, E2, and E3 RNAs that were enriched in high-molecular-weight fractions of nucleolar RNA. Some of these psoralen adducts might be cross-links of E1, E2, and E3 RNAs to large nucleolar RNA. Antisense oligodeoxynucleotide-targeted RNase H digestion of nucleolar extracts revealed accessible segments in these three small RNAs. The accessible regions were within nucleotide positions 106 to 130 of E1 RNA, positions 24 to 48 and 42 to 66 of E2 RNA, and positions 7 to 16 and about 116 to 122 of E3 RNA. Some of the molecules of these small nucleolar RNAs sedimented as if associated with larger structures when both nondenatured RNA and a nucleolar extract were analyzed.
The Bacteriology of Human Milk

This enquiry into the bacteriology of human milk was prompted by our recent investigation of a case of entero-colitis in a breast-fed infant. In this case an abundant growth of a streptococcus was obtained from the faeces of the infant which was identical as far as we could determine with a streptococcus isolated from the mother's milk.
Arylazopyrazole AAP1742 Inhibits CDKs and Induces Apoptosis in Multiple Myeloma Cells via Mcl‐1 Downregulation

Inhibitors of cyclin‐dependent kinases 9 have been developed as potential anticancer drugs for the treatment of multiple myeloma. We have previously prepared a library of arylazo‐3,5‐diaminopyrazole inhibitors of CDKs. Here, we describe a novel member, AAP1742 (CDK9 inhibition with IC50 = 0.28 μm), that reduces the viability of multiple myeloma cell lines in low micromolar concentrations. Consistent with inhibition of CDK9, AAP1742 decreases the phosphorylation of RNA polymerase II and inhibits mRNA synthesis of anti‐apoptotic proteins Mcl‐1, Bcl‐2, and XIAP, followed by apoptosis in the RPMI‐8226 cell line in a dose‐ and a time‐dependent manner. These results are consistent with the biochemical profile of AAP1742 and further suggest cellular inhibition of CDK9 as a possible target for anticancer drugs.
A systematic approach for glandular structure segmentation from colon histopathology images

In this paper a method is proposed for segmenting glandular structures from Haematoxilyn and Eosin stained colon histopathology images. Gland includes three main structures: lumen, cytoplasm and cell nuclei. As the first step of the algorithm, k-means clustering algorithm is applied to cluster images to 3 clusters (lumen, cytoplasm and cell nuclei). Then, all lumen in each histopathology images are extracted. A set of textural and structural features are extracted from each lumen. Cytoplasm that are adjacent to each lumens are detected. Then a set of textural and structural features are extracted from each cytoplasm. At the next step, cell nuclei rings that are adjacent to each cytoplasm are detected. Then a set of textural and structural features are extracted from each cell nuclei rings. Three feature that extracted from lumen, cytoplasm and cell nuclei rings are combined as a feature vector. The extracted features are then fed into an SVM classifier with a RBF kernel. The experimental results show good capability of the proposed method for gland segmenting from colon histopathology images.
Delay time detection and accommodation for a networked DC motor control

This paper presents a control method that is effective to reduce the degenerative effects of delay time caused by a treacherous network. In present application a controlled DC motor is part of an inverted pendulum and provides the equilibrium of this system. The control of DC motor is accomplished at the distance through a treacherous network, which causes delay time in the control signal. A predictive technique is used so that it turns the system free of delay. A robust digital sliding mode controller is proposed to control the free-delay system. Due to the random conditions of the network operation, a delay time detection and accommodation strategy is also proposed. A computer simulation is shown to illustrate the design procedures and the effectiveness of the proposed method.
A tamper-proof log architecture for cloud forensics

Nowadays cloud computing is emerging as the best solution for small business owners to save money on infrastructure investment. Large organizations lent out their big data centers during slack time to generate more returns on the existing infrastructure. The small business owners avail the services from these datacenters. The trustworthiness of these clouds is very crucial in choosing a cloud service provider. The data provided by the cloud users or the cloud resources (Processor, storage and bandwidth) allocated to them should not be shared with other simultaneous users. If any security breach is suspected, evidence is needed to prove the cybernetic crime in the courts of law. Logs are used to record the activities taking place in a user session, which can be used as evidence later if crime is suspected. Then it becomes mandatory to provide secure and tamper proof log architecture so that the evidence can be preserved. This paper proposes a tamper proof architecture for securing logs in cloud architecture. The logs are created at IaaS layer of cloud as ultimately any user activity is mapped to machine operation. The performance of the proposed system is also analyzed and it works better than existing works.
Stackelberg Game Models of Supply Chain Dual-Channel Coordination in E-Markets

Under the service-price sensitive demand condition,the Stackelberg game models of supply chain dual-channel coordination in e-markets are established.The integrated decision and Stackelberg game for traditional channel and dual-channel are considered respectively.Two modes of supply chain coordination are studied,that is coordination between upriver and downriver companies and coordination between tradition channel and online direct channel.Finally,combining with the ecommerce practice of Shanghai Baosteel Yichang Co.,the simulating calculation and analysis for supply chain dual-channel are carried out.
Conductive SU8-silver composite photopolymer

A new electrically conductive photosensitive composite resist has been formulated and used to build micro-components. This composite material is based on the SU-8 photopolymer, an insulating negative-tone photoresist, in which silver nano-particles have been dispersed to enhance the electrical properties of the polymer. The properties of this new photosensitive composite have been characterized by optical and electrical measurements. The patterned composite structures can be obtained for a wide range of values of the electrical conductivity, by varying the powder volume fraction of the composite. The lateral resolution of the produced structures were evaluated, and depending on the patterning conditions, can be better than 5 /spl mu/m.
Loyalty To SMEs: A Pipe Dream In The Current Economic Climate?

Small to medium enterprises (SMEs) plays a vital role in the growth and development of a country. It is therefore critical for any country, especially developing countries, to support and enhance the development of SMEs. Although the external support t is critical; SME’s needs to create and build its own loyal customer base for growth and sustainability. Loyal occurs when customers choose to use a particular store rather than others. A well maintained customer base can affect the SME’s profitability in a positive manner. Quantitative research was undertaken by means of a self-administered questionnaire to establish the perception of South African SME owners regarding loyalty. The study revealed that the main drive for creating loyal customers is good products and services as well as competitive prices. It is hoped that this information will help SMEs to attract and keep loyal customers as it is more cost effective to retain loyal customers than it is to obtain new customers.
Neutralization of bacterial endotoxins by frog antimicrobial peptides

The ability of skin antimicrobial peptides of the southern bell frog, Litoria raniformis, to neutralize in vitro the endotoxin, proinflammatory lipopolysaccharide (LPS) complex, from two different gram‐negative bacterial pathogens, human pathogen Escherichia coli (0111:B4) and frog pathogen Klebsiella pneumoniae, was investigated. The LPS neutralization activity of the natural mixture of skin antimicrobial peptides was measured using chromogenic Limulus amebocyte lysate assays. These skin antimicrobial peptides neutralized the LPSs from both pathogens at physiologically relevant concentrations (IC50 < 100 µg/mL) showing their potential for non‐specific LPS neutralization in vivo in the skin of infected frogs and for development of anti‐endotoxin agents.
Gratuity purchasing at wineries: an investigation of the determining factors

Purpose – Wine and accessories bought partly or fully out of a perceived need to repay services received at a winery are defined here as gratuity purchasing. The purpose of the research is to identify factors that predict gratuity purchasing at wineries. Specifically, the study seeks to investigate the role of gratitude and obligation, along with other consumer characteristics, in purchasing.Design/methodology/approach – Winery visitors were sampled from six Texas wineries. A total of 357 questionnaires were analyzed. Hierarchical multiple regression, correlation and factor analyses were employed.Findings – Gratitude and obligation were found to be strong predictors of purchasing at wineries. Visitors who feel grateful to personnel and/or obliged to buy wine are likely to spend more money at wineries. Involvement and knowledge also appear to be related to purchasing.Practical implications – Since gratitude and obligation appear to be strong predictors of buying decisions, winery managers need to find ways.
Effects of transient noise reduction algorithms on speech intelligibility and ratings of hearing aid users.

PURPOSE The goal of this study was to assess the functional utility of transient noise reduction (TNR) algorithms available in hearing aids via speech intelligibility and user preferences. METHOD Two pairs of hearing aids, 1 pair each from Siemens and Unitron, were programmed for 17 hearing impaired individuals after a hearing evaluation. Intelligibility was measured for each participant for sentences presented in quiet, with 2 types of transient noise, multitalker babble, and in a combination of each type of transient noise and multitalker babble. Each condition was tested with TNR activated and TNR deactivated in a counterbalanced, single-blinded format. Subjective ratings of overall speech understanding, comfort, and sound quality were obtained for each condition. RESULTS A significant improvement in speech intelligibility was measured with the TNR activated when speech was presented in multitalker babble, in the presence of chair clang transient noises, and when combining these noises. Activation of the TNR algorithm did not result in significant improvements for any of the subjective ratings. CONCLUSIONS While improvements were limited to certain conditions, specifically those with the chair clang transient and/or multitalker babble, TNR appears to offer an incremental step in improving the listening experience for hearing aid users.
The Effects of Information Quality on Call Center Agents' Individual Impacts : Focused on Call Center Customer Service Information Systems

논문투고일:2013년 07월 26일 논문수정완료일:2014년 03월 05일 논문게재확정일:2014년 03월 09일 * 이 논문은 2013학년도 건국대학교의 연구년교원 지원에 의하여 연구되었음. ** 건국대학교 일반대학원 정보통신경영학과 석사, 주저자 *** 건국대학교 경영대학 경영정보전공 교수, 교신저자 **** 건국대학교 경영대학 경영정보전공 교수, 공동저자 ***** 건국대학교 정보기술아웃소싱연구소 연구원, 공동저자 This paper is a study on information Quality of Domestic Call Center Information System; recognized the importance of information quality and analyzed the impact on use and satisfaction of users following information quality which is a success element and ultimately the impact on user’s performance by expanding information quality evaluating model by Jeong-Woo Lee et al.(2003) who reflected domestic special corporate culture based on information system success model by DeLone and McLean(2003). This is meaningful in providing theoretical foundation for efficient information quality supply and building quality management system at call center in future and provides hints to be considered in raising understanding of consultants on provided information and arranging ground that can utilize it
A rotary actuator using shape memory alloy for a robot -analysis of the response with load

Deals with the response of the actuator using shape memory alloy (SMA). The SMA actuator was developed for a robot. This study aims at the development of the position control system; control parameters are set automatically for the SMA actuator drives any kind of load. The SMA actuator in this study is box type actuator which is installed to a robot. This SMA actuator is compact. It works by repeat cooling and heating of the SMA wire. Step response and frequency response of the SMA actuator system without load showed good experimental results. Performance of SMA actuator system was calculated using results of the step response and other experimental results. Experimental results of the step response when the authors installed load to transmission shaft of the SMA actuator were shown. The step response data of experimental results were used for identification of the SMA actuator system. Results of identification on the SMA actuator system were calculated as a transfer function. Experimental results and identification results of the SMA actuator system were presented. <<ETX>>