Miracle-dz/UniFAR-FTUs huggingface dataset:
Allogeneic Bone Marrow Transplantation in Juvenile Myelomonocytic Leukemia Without Total Body Irradiation

Allogeneic bone marrow transplantation (BMT) without a total body irradiation (TBI) conditioning regimen was investigated in children with juvenile myelomonocytic leukemia (JMML). Eight consecutive patients with JMML (n = 6) or monosomy 7 (n = 2) underwent BMT at a median age of 20 months. Donor source included fully matched related (n = 3), mismatched related (n = 2), or fully matched unrelated (n = 3). The conditioning regimen included busulfan, cyclophosphamide, and etoposide (VP16) (melphalan was substituted for VP16 in one patient). The first patient in the series underwent TBI. Graft-versus-host disease prophylaxis was with cyclosporin and methotrexate and in vivo T-cell depletion (Campath 1 g) for mismatched and unrelated transplants. Seven and two patients, respectively, received chemotherapy and splenectomy before BMT. At a median follow-up of 48 months after BMT, five patients remained in remission. The overall survival rate was 63% at 5 years. All deaths occurred in patients with refractory disease at the time of BMT. Allogeneic BMT without TBI appears to be effective therapy for JMML and avoids some of the potential late sequelae of TBI in preschool children.
Distinguishing Gastrointestinal Stromal Tumors From Their Mimics: An Update

Since the discovery of activating KIT mutations in gastrointestinal stromal tumors (GISTs) in 1998 and the subsequent demonstration that some malignant GISTs respond to targeted therapy with imatinib, it has become increasingly important for pathologists to correctly diagnose GISTs and separate them from their potential mimics in the gastrointestinal tract and abdominal cavity. Some mesenchymal tumors, such as leiomyomas of the muscularis mucosae, are easily distinguished from GIST on the basis of their anatomic location and morphologic appearance. Others, such as gastrointestinal schwannomas, can significantly overlap with GIST in their gross appearance and morphology and require a panel of immunostains for correct diagnosis. This article will review the most common mimics of GISTs: desmoid tumors, smooth muscle tumors (leiomyomas and leiomyosarcomas), gastrointestinal schwannomas, inflammatory fibroid polyps, and solitary fibrous tumors. Pertinent differences between each of these tumors and GIST in terms of gross appearance, histologic features, and immunophenotype will be emphasized. It is important to separate GISTs from these potential mimics because their treatment and prognosis can differ markedly.
The Validity and Reliability of Pain Measures for use in Clinical Trials in Adults : Review Paper

In order to be most useful, clinical trials of pain treatments should use measures that are both reliable and valid. The purpose of this paper is to summarize the evidence concerning the validity and reliability of pain measures that can be used in clinical trials of pain treatments. The results of this review indicate that commonly used single-item ratings of pain intensity are all valid and adequately reliable as measures of pain intensity, although some scales appear to be easier for patients to understand and use than others. There is less research examining the psychometric properties of measures of pain dimensions other than pain intensity, such as pain relief, the temporal aspects of pain, and pain quality (including pain affect). This lack of evidence limits the conclusions that may be drawn concerning the reliability and validity of these other measures for use in clinical trials. The discussion includes specific recommendations for selecting from among the available pain measures, as well as recommendations for future research into the pain assessment for clinical trials.
Évaluation de politiques d'adaptation au risque de collisions dans un consensus de type « Fast Paxos »

Aucune collision ne se produit durant une instance de consensus si toutes les valeurs proposees durant ce consensus sont identiques. Afin de reduire le temps necessaire a une prise de decision, certains protocoles de consensus anticipent sur le fait qu'aucune collision ne se produira au cours du prochain consensus execute. Ce principe de conception a notamment ete etudie par Lamport qui a propose une variante au protocole Paxos, appelee Fast Paxos. En l'absence de collision, un gain de temps est observe. Malheureusement, le fait de declencher cette optimisation revient a faire un pari sur l'avenir et, en cas de collision non prevue, le cout de la procedure de recouvrement s'avere etre bien plus important que le gain initialement escompte. Dans cet article, nous decrivons brievement le protocole Paxos-MIC qui permet d'executer une sequence d'instances de consensus. Apres chaque consensus, le choix d'activer l'optimisation risquee durant le prochain consensus est fait localement et dynamiquement en evaluant une condition de declenchement. Nous etudions differentes conditions de declenchement et nous evaluons les gains susceptibles d'etre obtenus en analysant le comportement du protocole a l'aide d'une trace reelle correspondant a l'activite du site web d'une grande ecole d'ingenieur durant quinze jours consecutifs.
The impact of the typhoon to East Malaysia on orographic effect

East Malaysia has few mountains ranges which are believed to affect the cloud and rainfall distribution patterns during severe weather especially typhoon season. The study objectives are to investigate and determine the relationship between the typhoon impacts and the topography of East Malaysia. The highest mountain range in East Malaysia was the Crocker Range in Sabah, which divides the state into half. Mountain ranges in the East tend to follow north-south or northeast-southwest paths, rising to over 4095.2 meters houses by Mount Kinabalu, the highest mountain in the country, as well as Mount Trusmadi (2642m) and Mount Tambuyukon (2579m), the second and third highest peak in the country. Typhoon Ketsana was chosen for this study. The hourly rainfall products were obtained from FengYun-2D geostationary satellite. Radiosonde data from Kota Kinabalu station with Skew-T diagram and hodograph were applied in this study. A total of 5 distinct results were found in this cloud and rainfall-orography interaction during the typhoon activity. First, parts of the cloud were blocked by the Crocker Range and caused to slow down of rainfall event for a moment. Second, the heavy rainfall occurred around these mountains range. Third, the variation of cloud and rainfall distribution pattern was related to the mountain shape. Fourth, if the raining cloud was high enough and there were extra outside energy (typhoon system) the rainfall process may be forced to move forward and pass through these mountains range. Besides that, heavy rainfall distribution was more affected by the high mountains close to the shoreline than the interior region of the island. Based on this study, orography effect was important to the weather forecaster since the high mountain range was able to influence the distribution of the cloud and even rainfall patterns during typhoon season.
Epidemiology of youth suicide and suicidal behavior

Purpose of review Suicide is the third leading cause of death among young people in the U.S. and represents a significant public health problem worldwide. This review focuses on recent developments in our understanding of the epidemiology and risk factors for adolescent suicide and suicidal behavior. Recent findings The suicide rate among children and adolescents in the U.S. has increased dramatically in recent years and has been accompanied by substantial changes in the leading methods of youth suicide, especially among young girls. Much work is currently underway to elucidate the relationships between psychopathology, substance use, child abuse, bullying, internet use, and youth suicidal behavior. Recent evidence also suggests sex-specific and moderating roles of sex in influencing risk for suicide and suicidal behavior. Summary Empirical research into the causal mechanisms underlying youth suicide and suicidal behavior is needed to inform early identification and prevention efforts.
Measurements of unloaded Q-factor of transmission mode dielectric resonators

A procedure to determine accurately the unloaded Q-factor, resonant frequency and coupling coefficients of a dielectric resonator in the transmission mode has been developed. The technique is based on a derived equation relating S/sub 21/ and Q/sub L/, measurements of S/sub 21/, S/sub 11/ and S/sub 22/ and accounts for crosstalk, coupling and cable losses.
Barriers to and Facilitators of Stocking Healthy Food Options: Viewpoints of Baltimore City Small Storeowners

ABSTRACT Receptivity to strategies to improve the food environment by increasing access to healthier foods in small food stores is underexplored. We conducted 20 in-depth interviews with small storeowners of different ethnic backgrounds as part of a small-store intervention trial. Store owners perceived barriers and facilitators to purchase, stock, and promote healthy foods. Barriers mentioned included customer preferences for higher fat and sweeter taste and for lower prices; lower wholesaler availability of healthy food; and customers’ lack of interest in health. Most store owners thought positively of taste tests, free samples, and communication interventions. However, they varied in terms of their expectations of the effect of these strategies on customers’ healthy food purchases. The findings reported add to the limited data on motivating and working with small-store owners in low-income urban settings.
Magnetic Instability in  ${\hbox{MgB}}_{2}$ Monofilamentary Tapes

The magnetic instability in MgB2 monofllamentary tapes with nickel alloy matrix has been investigated by measuring hysteresis loops and magnetic relaxation. The measurements have been performed in the temperature range from 2 K up to 39 K, applying an external magnetic field up to 20 kOe both parallel and perpendicular to the filament direction. We have analysed the magnetic instability by using an adiabatic and dynamical approach and taking also into account the effects of the samples geometry on the magnetic properties. In this work we discuss the observed dependence of the flux jumps on the temperature and on the applied magnetic field taking into account the recent results on the magnetic instability in a superconductor placed in a perpendicular magnetic field.
Packaging of Mason-Pfizer monkey virus (MPMV) genomic RNA depends upon conserved long-range interactions (LRIs) between U5 and gag sequences

MPMV has great potential for development as a vector for gene therapy. In this respect, precisely defining the sequences and structural motifs that are important for dimerization and packaging of its genomic RNA (gRNA) are of utmost importance. A distinguishing feature of the MPMV gRNA packaging signal is two phylogenetically conserved long-range interactions (LRIs) between U5 and gag complementary sequences, LRI-I and LRI-II. To test their biological significance in the MPMV life cycle, we introduced mutations into these structural motifs and tested their effects on MPMV gRNA packaging and propagation. Furthermore, we probed the structure of key mutants using SHAPE (selective 2′hydroxyl acylation analyzed by primer extension). Disrupting base-pairing of the LRIs affected gRNA packaging and propagation, demonstrating their significance to the MPMV life cycle. A double mutant restoring a heterologous LRI-I was fully functional, whereas a similar LRI-II mutant failed to restore gRNA packaging and propagation. These results demonstrate that while LRI-I acts at the structural level, maintaining base-pairing is not sufficient for LRI-II function. In addition, in vitro RNA dimerization assays indicated that the loss of RNA packaging in LRI mutants could not be attributed to the defects in dimerization. Our findings suggest that U5-gag LRIs play an important architectural role in maintaining the structure of the 5′ region of the MPMV gRNA, expanding the crucial role of LRIs to the nonlentiviral group of retroviruses.
Age‐Associated Changes of the Mandibular Foramen Position in Anteroposterior Dimension and of the Mandibular Angle in Dry Human Mandibles

The effect of age on the anteroposterior (A‐P) position of the mandibular foramen (MF) and on the size of the gonial angle (GA) was evaluated in this study. From an Israeli Bedouin population, 121 dry mandibles with primary (36), mixed (26), and permanent dentitions (59) were analyzed. The A‐P position of the MF perpendicular to the posterior border of the ramus was measured with a digital caliper. A mandibulometer was used to evaluate the GA. The MF distance from the posterior border of the ramus increased significantly with age by 66% from primary (7.75 mm) to permanent (12.9 mm; P < 0.001). Similarly, the MF distance from the posterior border of the ramus relative to the total ramus width in A‐P dimension increased significantly (21.4%) with altered dentitions from primary (0.28) to late permanent dentition (0.34; P < 0.001). The GA decreased significantly with age from 140.17° ± 5.9° (primary dentition) to 123.61° ± 6.9° (late permanent dentition; P < 0.001). The anterior movement of the MF and the decreased size of the GA that occurred with changing dentition were related to growth process. The MF moves anteriorly, and the GA decreases with age. Anat Rec, 2011. © 2011 Wiley‐Liss, Inc.
Using ontologies for annotating and retrieving protein-protein interactions data

Protein-Protein Interaction (PPI) databases store the whole set of protein interactions in organism. In spite of the availability of much biological information spread on different sources (e.g. Gene Ontology), neither proteins nor interactions are generally annotated in PPI databases. This results in very poor querying capabilities of PPI databases that enable very simple queries. The annotation of proteins and interactions stored in PPI databases may allow the implementation of more powerful querying interfaces. The paper presents a software architecture for the annotation of existing PPI databases with information extracted from Gene Ontology. A simple extension of the query interface of an existent PPI database is discussed.
OS 20-03 THE ASSOCIATIONS BETWEEN EACH COMPONENT OF BLOOD PRESSURE AND TARGET ORGAN DAMAGES IN PATIENTS AT HIGH RISK OF CORONARY ARTERY DISEASE

Objective: Data from systemic evaluation of the influence of each component of blood pressure (BP) on various target organ damages (TODs) has been limited. This study was performed to elucidate which BP component was associated with TODs in patients with high risk of coronary artery disease (CAD). Design and Method: Study data were obtained from a nation-wide registry, composed of 652 patiens (471 women with 58.4 ± 10.5 year old) with suspected CAD who underwent invasive coronary angiography (CAG). The associations between each brachial BP component [systolic and diastolic BP (SBP and DBP), mean arterial pressure (MAP) and pulse pressure (PP)] and [left ventricular mass index (LVMI), estimated glomerular filtration rate (eGFR), left ventricular filling pressure (E/e’) and CAD] were analyzed. Results: A total of 219 patients (21.9%) had obstructive CAD (≥ 50%) in CAG. In univariate analysis, only DBP was correlated with LVMI, and SPB with eGFR, but these correlations disappeared in multivariable analyses. SBP (r = 0.227), MAP (r = 0.135) and PP (r = 0.257) had significant and positive linear correlations with E/e’ (P < 0.05 for each). These correlations remained even after controlling for potential confounders. SBP and PP were the independent predictors for obstructive CAD, on the other hand, DBP and MAP were not associated with obstructive CAD. Conclusions: Among middle-aged and elderly Korean patients at high risk of CAD, each BP component had a different influence on TODs. Targeting SBP and PP rather than DBP and MAP is possibly more efficient in preventing LV diastolic dysfunction and CAD in this group of patients.
Effect of package and storage conditions on viability and efficacy of the freeze‐dried biocontrol agent Pantoea agglomerans strain CPA‐2

Aims: To reduce concentrations of protective and rehydrating media and to evaluate the effect of storage temperature, packaging and atmosphere conditions on the stability of freeze‐dried Pantoea agglomerans cells. Efficacy against Penicillium digitatum of freeze‐dried cells in orange fruits was also evaluated.
Candida Albicans Involvement in Denture-Related Stomatitis: A Serious and Real Clinical Concern

Denture stomatitis, also known as atrophic candidiasis, remains the most frequent form of oral candidiasis, being detected in approximately 25%-65% of denture-wearing patients. Denture stomatitis is characterized by an erythematous inflammation of mucosal areas covered by prosthesis with preferential localization in the palatal mucosa. Although the clinical entity of this infectious disease is multifactorial, Candida albicans is the major etiological agent. The treatment of this oral infection is difficult because failures and recurrences are extremely common. In the present opinion article, we have presented a brief review on this oral pathology, summarizing the main predisposing factors, clinical diagnosis and current effective options to prevent and treat the affected population.
Evaluating the outcomes of low vision rehabilitation

The requirement for those providing healthcare to measure outcomes raises the fundamental question of how these should be measured. Both the scale of the low vision population and the different models of care proposed make it a pressing need to determine outcomes using valid and reliable measures. In this study we describe the development and piloting of a questionnaire designed to meet this requirement. The questionnaire was piloted on 56 subjects with age‐related macular degeneration (ARMD). Test‐retest reliability of the questionnaire was estimated using a further sample of 28 subjects with ARMD. Pilot testing confirmed the feasibility of administering the questionnaire to an elderly population with ARMD. A total of 87% of the sample reported using an LVA (65% on a daily basis), predominantly for a reading task. The number of tasks an LVA was used for, its frequency of use, length of continuous use and ease of use are significantly associated with the rating of an LVA as important/less important (P<0.0001), but the acuity achieved with the device is not significantly associated with rated importance (P=0.11), reinforcing doubt about the validity of visual function outcomes. The limitations of this pilot study and earlier case series in describing the outcomes of low vision care are discussed and a randomised controlled trial using a broad range of outcomes is proposed in order to fully describe the effectiveness of low vision rehabilitation and inform the debate about models of care.
Association of HLA-DR5 with mycosis fungoides.

Mycosis fungoides (MF) and Sézary syndrome (SS) are uncommon neoplasms of the lymphoreticular system with distinct clinical, histologic, and immunologic features. Based on the thymus-derived nature of the neoplastic cells, MF and SS are both classified as cutaneous T-cell lymphoma. While substantially greater understanding of MF and SS has been made possible, the exact mechanism for the initiation of either disease is still unknown. The possible involvement of environmental factors as well as viral etiology, i.e., retroviruses, has been suggested. In order to investigate the possible role of HLA-associated variations in genetic susceptibility, 74 patients with histologically documented MF were typed for HLA-A, -B, and -C antigens. Half of these patients were also typed for HLA-DR antigens. An increase in DR5 was the only statistically significant deviation in HLA antigen frequencies in these patients (53% in MF as compared with 20% in controls). An increased frequency of HLA-DR5 has also been associated with scleroderma and juvenile rheumatoid arthritis both of which have immunologic alterations. Also HLA-DR5 has been associated with renal cell carcinoma and Kaposi's sarcoma. The association of MF with DR5 suggests that some individuals with the DR5 antigen may be at higher risk for virally initiated and/or neoplastic diseases possibly through an HLA-linked defect in the immune system.
Load bearing characteristics of the patello-femoral joint.

This study of normal patello-femoral biomechanics defines some functional specifications which may be useful in future total knee prosthesis design. Serial lateral X-rays of 15 fresh knees and their patellar mechanisms at several flexion angles provided definition of the direction of the resolved patello-femoral forces. Assuming that the patella acts as a frictionless pulley, the magnitude of the patello-femoral forces during several activities was calculated using data from Morrison (1970) and Smidt (1973). It ranged between 421 and 3420 newtons for the various activities and for isometric exercise. A methylene blue contact print technique was used to measure the bearing areas. These data indicate that between 13 and 38 per cent of the patellar surface bears joint loadings. Patello-femoral contact stresses were calculated to range from 1.28 to 12.6 N/mm2. A 696 new-ton man climbing stairs would, for example, generate a patello-femoral force of 1754 newtons and would experience patello-femoral contact str.
The 6‐minute walk test as a new outcome measure in Duchenne muscular dystrophy

Walking abnormalities are prominent in Duchenne muscular dystrophy (DMD). We modified the 6‐minute walk test (6MWT) for use as an outcome measure in patients with DMD and evaluated its performance in 21 ambulatory boys with DMD and 34 healthy boys, ages 4 to 12 years. Boys with DMD were tested twice, ∼1 week apart; controls were tested once. The groups had similar age, height, and weight. All tests were completed. Boys who fell recovered rapidly from falls without injury. Mean ± SD [range] 6‐minute walk distance (6MWD) was lower in boys with DMD than in controls (366 ± 83 [125–481] m vs. 621 ± 68 [479–754] m; P < 0.0001; unpaired t‐test). Test‐retest correlation for boys with DMD was high (r = 0.91). Stride length (R2 = 0.89; P < 0.0001) was the major determinant of 6MWD for both boys with DMD and controls. A modified 6MWT is feasible and safe, documents disease‐related limitations on ambulation, is reproducible, and offers a new outcome measure for DMD natural history and therapeutic trials. Muscle Nerve, 2010
Extracting Criminal-Related Events from Arabic Tweets: A Spatio-Temporal Approach

Recently,﻿Twitter﻿as﻿one﻿of﻿social﻿networks﻿has﻿been﻿considered﻿as﻿a﻿rich﻿source﻿of﻿spatio-temporal﻿ information﻿and﻿significant﻿revenue﻿for﻿mining﻿data. ﻿Event﻿detection﻿from﻿tweets﻿can﻿help﻿to﻿predict﻿ more﻿serious﻿real-world﻿events. ﻿Such﻿as:﻿criminal﻿events,﻿natural﻿hazards,﻿and﻿the﻿spread﻿of﻿epidemics. ﻿ Etc.﻿This﻿paper﻿deals﻿with﻿event-based﻿extraction﻿for﻿criminal﻿incidents﻿from﻿Arabic﻿tweets. ﻿It﻿presents﻿ a﻿framework﻿that﻿supports﻿automated﻿extraction﻿of﻿spatial﻿and﻿temporal﻿information﻿from﻿tweets. ﻿ The﻿proposed﻿approach﻿is﻿based﻿on﻿combining﻿various﻿ indicators,﻿ including﻿the﻿names﻿of﻿places﻿ and﻿temporal﻿expressions﻿that﻿appear﻿in﻿the﻿tweet﻿message,﻿related﻿tweeting﻿time,﻿and﻿additional﻿ locations﻿from﻿the﻿user’s﻿profile. ﻿The﻿effectiveness﻿of﻿the﻿system﻿was﻿evaluated﻿in﻿term﻿of﻿recall,﻿ precision﻿and﻿f-measure. KEywoRdS Arabic Language Processing, Gazetteers, Information Extraction, Processing Tweets, Spatiotemporal Information