Miracle-dz/UniFAR-FTUs huggingface dataset:
Solution for Dead Space Problem in Ranibizumab Syringe System

Intravitreal injection of drugs that inhibit the actions of vascular endothelial growth factor bring high economic burden for the health systems. We evaluated the amount of drug volume retained in two different types of syringes with billed and non billed rubber stopper. Difference between two syringe types is 0.037 g. This indicates a significant amount of volume loss due to dead space between syringe and needle. Consequently, a simple change of design of rubber stopper of the plunger as billed form may reduce significant amount of drug loss due to dead space volume.
Teaching ERP Systems by a Multiperspective Approach

In this paper we describe how a market-leading ERP system can be used to demonstrate theoretical knowledge of Enterprise Systems. Students of business administration with a focus on information systems are taught theoretical backgrounds about modeling, technical architectures, development, and conceptions of Enterprise Systems. They know about business processes like production planning or material management. However, links between business knowledge, theoretical IT-knowledge, and practical IT-experience are not revealed to the students. To close this gap we propose an integrative ERP curriculum, which maps different theoretical IT-knowledge to Enterprise Systems. Therefore an ERP system is determined from different perspectives like end-users or IT-specialists. Using exemplary processes like purchasing or MRP, the integrative aspect of Enterprise Systems is demonstrated. The introduced concept is not about teaching a specific ERP system but illustrates concepts of ERP like data integration, data structure integration, process integration, and maps information models onto ERP systems.
Variabilité architecturale et fonctionnelle du système aérien chez le pommier (Malus domestica Borkh.): comparaison de quatre cultivars par une approche de modélisation structure-fonction

Au dela de la diversite architecturale bien decrite entre varietes chez le pommier, une variabilite fonctionnelle est suspectee, encore tres mal connue, qui pourrait se repercuter sur leur productivite et sur leurs capacites d'adaptation. Par ailleurs, il est postule que la variabilite fonctionnelle des cultivars a une echelle integree depend a la fois de l'organisation architecturale de leur systeme aerien et d'une variabilite du fonctionnement de leur feuillage. La comparaison qui a ete realisee entre genotypes a porte sur 4 cultivars de pommier : Fuji et Braeburn d'une part, Ariane et X3305 d'autre part, dont les arbres etaient respectivement âges de sept ans et de deux ans au debut de l'etude. Les arbres ont ete cultives dans un verger experimental irrigue et soumis a des pratiques culturales standard. L'etude de la variabilite architecturale entre arbres a mis en evidence des differences de dynamique de mise en place de la surface foliaire entre individus jeunes et plus âges. Des differences de composition rameale entre arbres de meme âge ont egalement ete revelees, ayant pour consequence des differences d'efficience d'interception lumineuse entre cultivars qui ont ete quantifiees par le parametre STAR (Silhouette to Total leaf Area Ratio). Une methode de description de la structure des arbres en 3D, reposant sur une approche mixte de digitalisation et de reconstruction du feuillage, a ete validee. L'etude fonctionnelle a l'echelle foliaire a mis en evidence une diversite de la regulation stomatique des 4 genotypes en reponse aux facteurs abiotiques (modele de Jarvis), alors que les parametres photosynthetiques (modele biochimique de Farquhar) s'averaient peu variables. Les caracteristiques architecturales et fonctionnelles de chaque cultivars ont ete prises en compte dans la parametrisation et l'utilisation du modele structure-fonction RATP, afin d'evaluer l'impact de leur couplage sur les capacites d'interception lumineuse, de transpiration et d'assimilation de carbone a l'echelle integree de la branche fruitiere. Une analyse de sensibilite du modele pour le cultivar Braeburn a permis de mettre en evidence le role preponderant de l'architecture des arbres dans la variabilite de fonctionnement a cette echelle. Les perspectives ouvertes par cette approche ecophysiologique chez le pommier au moyen d'un modele structure fonction sont discutees.
Biographical Dictionary of the Board of Governors of the Federal Reserve

Preface Introduction by George G. Sause Wayne D. Angell by Robert C. Winder C. Canby Balderston by Nancy M. Thornborrow Eugene Robert Black by Ogden O. Allsbrook, Jr. Andrew Felton Brimmer by Rexford Ahene Joseph A. Broderick by Yale L. Meltzer Jeffrey M. Bucher by Thomas J. Pierce Arthur F. Burns by John P. Cullity Milo D. Campbell by Jean-Claude Leon Lawrence Clayton by Philip Lane Philip E. Coldwell by David E. R Gay and Thomas R. McKinnon Daniel Richard Crissinger by James W. Schmotter Edward H. Cunningham by Ronald Robbins J. Dewey Daane by Yale L. Meltzer Chester Charles Davis by Jack B. White Frederic Adrian Delano by Juli Cicarelli Ernest G. Draper by Philip Lane Marriner Stoddard Eccles by William J. Barber Rudolph Martin Evans by Donald R. Wells Stephen Symmes Gardner by Neela D. Manage Lyle E. Gramley by Marie McKinney Alan Greenspan by Thomas Havrilesky and Bernard S. Katz Charles Sumner Hamlin by Michael Connell W. Proctor Harding by Geofrey T. Mills Heinz Robert Heller by Bernard S. Katz Robert C. Holland by Penny Kugler Philip Chappell Jackson, Jr. by Kathie S. Gilbert George Roosa James by Jean-Claude Leon Manuel H. Johnson by Robert C. Winder Edward W. Kelley by Jack B. White John P. LaWare by Jack B. White David Maher Lilly by Neela D. Manage Thomas Bayard McCabe by Earl W. Adams Wayland Wells Magee by Cynthia Saltzman Sherman J. Maisel by Jane M. Simmons Preston Martin by Annette Meyer William McChesney Martin, Jr. by Daniel Vencill John Keown McKee by Nancy M. Thornborrow Eugene Meyer by James N. Marshall Adolph Caspar Miller by Robert Stanley Herren G. William Miller by Marie McKinney Paul Emmert Miller by Bernard S. Katz Abbot Low Mills, Jr. by Thomas J. Pierce George Wilder Mitchell by Mary Murphy John R. Mitchell by Paul J. Kubik Henry A. Moehlenpah by Shiva Sayeg Ralph W. Morrison by David E. R. Gay and Thomas R. McKinnon David W. Mullins, Jr. by Bernard S. Katz Edward Lee Norton by Anne R. Hornsby John Charles Partee by Anne R. Hornsby Edmund Platt by David J. Leahigh Oliver S. Powell by Cynthia Saltzman Ronald Ransom by Jack B. White Emmett J. Rice by Jane M. Simmons James Louis Robertson by Penny Kugler Frederick H. Schultz by Gregory A. Claypool Martha Romayne Seger by Robert C. Winder John Eugene Sheehan by Yale L. Meltzer Charles Noah Shepardson by David E. R Gay and Thomas R. McKinnon William Wayne Sherrill by David E. R Gay and Thomas R. McKinnon Albert Strauss by Robert Metts Menc Stephen Szymczak by Gregory A. Claypool Nancy Hays Teeters by Juli Cicarelli John Jacob Thomas by Donald R. Wells James Kimble Vardaman, Jr. by Yale L. Meltzer Paul Adolph Volcker, Jr. by Robert Stanley Herren Henry Wallich by David J. Leahigh Paul Moritz Warburg by Robert Stanley Herren David C. Wills by Paul J. Kubik Roy Archibald Young by Vibha Kapuria-Foreman Index
Transcriptional Regulation of Cortical Neuron Migration by POU Domain Factors

The identification of pathways mediated by the kinase Cdk5 and the ligand reelin has provided a conceptual framework for exploring the molecular mechanisms underlying proper lamination of the developing mammalian cerebral cortex. In this report, we identify a component of the regulation of Cdk5-mediated cortical lamination by genetic analysis of the roles of the class III POU domain transcription factors, Brn-1 and Brn-2, expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons. Brn-1 and Brn-2 appear to critically control the initiation of radial migration, redundantly regulating the cell-autonomous expression of the p35 and p39 regulatory subunits of Cdk5 in migrating cortical neurons, withBrn-1(−/−)/Brn-2(−/−) mice exhibiting cortical inversion.
Neuropsicología cultural en población árabe: evaluación en adultos y niños

Esta tesis doctoral es un estudio sobre el campo de neuropsicologia transcultural destacando las diferencias culturales encontradas en el rendimiento neuropsicologico y las variables que pueden explicar estas diferencias. El objetivo principal de esta Tesis es iniciar un programa de investigacion sobre la neuropsicologia cultural en poblacion arabe en general, comprobar el papel de variables tradicionales como la aculturacion, clase socio-ocupacional e inteligencia y nuevas variables, como las habilidades de calculo, a la hora de explicar las diferencias culturales en el rendimiento neuropsicologico entre tres grupos (marroqui, espanol y colombiano) igualadas en edad, sexo, nivel educativo y nivel socio-economico.
A very short term wind power prediction approach based on Multilayer Restricted Boltzmann Machine

The wind power prediction (WPP) is challenging as a large amount of data with complex nonlinear relationship should be fitted by the prediction method. To improve the accuracy, WPP based on the Multilayer Restricted Boltzmann Machine (MRBM), which is a deep learning neural network with strong feature interpretation ability, is presented in the paper. To explore the influencing factors of prediction accuracy, the number of hidden layers and the number of nodes in each layer of MRBM are studied. Furthermore, the classic Back Propagation Neural Network (BPNN) based WPP, as a reference, is compared with the MRBM method. The results show that the accuracy of MRBM based WPP is higher than that of BPNN based WPP. The Root Mean Square Error (RMSE) of the MRBM based prediction is 4.5% lower than that of BPNN in some period, and the error distribution of MRBM based WPP is with better concentration ability than that of BPNN based WPP.
Deficits in Selective Attention in Symptomatic Huntington Disease: Assessment Using an Attentional Blink Paradigm

Background:Impaired selective attention in Huntington disease (HD) may manifest as difficulty in identifying a single target embedded among a series of distractors in rapid serial visual presentation tasks. Method:We used an attentional blink (AB) paradigm to examine whether attentional control is impaired in symptomatic HD. Fourteen HD patients and 13 age-matched healthy controls performed a rapid serial visual presentation task in which 2 targets (T1 and T2) and numerous distractors were presented in rapid succession. We assessed the accuracy of T1 identification and the AB (impaired T2 detection after the correct identification of T1). Results:Among the HD patients, identification of T1 was significantly impaired and AB was significantly larger but not longer. The HD patients also made significantly more random errors. Conclusions:Frontostriatal or frontoparietal dysfunction is likely to compromise attentional control in HD, such that well-masked and rapidly presented target stimuli are difficult to detect and identify, especially as the difficulty level increases. Although we previously reported no AB deficits in presymptomatic HD, with manifest disease we found that the progressive frontoparietal cortical changes compromise attentional control mechanisms.
Characterization of Fxr1 in Danio rerio; a simple vertebrate model to study costamere development

SUMMARY The X-linked FMR1 gene, which is involved in the fragile X syndrome, forms a small gene family with its two autosomal homologs, FXR1 and FXR2. Mouse models for the FXR genes have been generated and proved to be valuable in elucidating the function of these genes, particularly in adult mice. Unfortunately, Fxr1 knockout mice die shortly after birth, necessitating an animal model that allows the study of the role of Fxr1p, the gene product of Fxr1, in early embryonic development. For gene function studies during early embryonic development the use of zebrafish as a model organism is highly advantageous. In this paper the suitability of the zebrafish as a model organism to study Fxr1p function during early development is explored. As a first step, we present here the initial characterization of Fxr1p in zebrafish. Fxr1p is present in all the cells from zebrafish embryos from the 2/4-cell stage onward; however, during late development a more tissue-specific distribution is found, with the highest expression in developing muscle. In adult zebrafish, Fxr1p is localized at the myoseptum and in costamere-like granules in skeletal muscle. In the testis, Fxr1p is localized in immature spermatogenic cells and in brain tissue Fxr1p displays a predominantly nuclear staining in neurons throughout the brain. Finally, the different tissue-specific isoforms of Fxr1p are characterized. Since the functional domains and the expression pattern of Fxr1p in zebrafish are comparable to those in higher vertebrates such as mouse and human, we conclude that the zebrafish is a highly suitable model for functional studies of Fxr1p.
The S18 Ribosomal Protein Is a Putative Substrate for Ca2+/Calmodulin-activated Protein Kinase II*

The δ-isoform of Ca2+/calmodulin-activated protein kinase II (CaMK II) is abundantly expressed in vascular smooth muscle, but relatively little is known about its regulation or its potential cellular substrates. There are few, if any, known substrates of CaMK II that are physiologically relevant in vascular smooth muscle cells. Studies presented earlier (Mishra-Gorur, K., Singer, H. A., and Castellot, J. J., Jr. (2002) Am. J. Pathol. , in press) by our laboratory show an inhibitory effect of heparin on CaMK II phosphorylation and activity. During these studies we observed the specific co-immunoprecipitation of a 20-kDa protein with CaMK II. Purification and sequence analysis indicate that this protein is the S18 protein of the 40 S ribosome. S18 was found to be abundantly phosphorylated in response to serum treatment, and this effect was strongly inhibited by heparin. In addition, KN-93, a specific CaMK II inhibitor, blocks S18 phosphorylation in vascular smooth muscle cells; a concomitant 24% reduction in protein synthesis was observed. Taken together these data support the idea that S18 could be a novel substrate for CaMK II, thus providing a potential link between Ca2+-mobilizing agents and protein translation.
Anaplastic large cell lymphoma presenting with paraneoplastic pemphigus

Paraneoplastic pemphigus is an autoimmune acantholytic mucocutaneous disorder that rarely accompanies an overt or occult neoplasm. Typical features include painful mucosal erosive lesions and pruritic papulosquamous eruptions that often progress to blisters. The antibody is a unique immunoglobulin G that recognises epidermal proteins. We discuss the case of a 23-year-old woman who presented with anaplastic large cell lymphoma complicated by paraneoplastic pemphigus, rapidly resulting in fatal multiorgan failure. A 23-year-old woman presented with 1 week of fever and a disseminated erythrodermic rash with desquamation of the hands and feet, and erosions in the mouth. A local doctor started treatment with ciprofloxacin and prednisolone. A diagnosis of toxic epidermal necrolysis was made. On day 4, she required intubation, ventilation and transfer to a tertiary referral centre. …
Analysis and Design of the Integrated Double Buck–Boost Converter as a High-Power-Factor Driver for Power-LED Lamps

In this paper, an integrated double buck-boost (IDBB) converter is proposed as a high-power-factor offline power supply for power-LED lamps. The IDBB converter features just one controlled switch and two inductors and is able to supply a solid-state lamp from the mains, providing high power factor and good efficiency. In this paper, the IDBB converter is analyzed, and a design methodology is proposed. It is demonstrated that, with a careful design of the converter, the filter capacitances can be made small enough so that film capacitors may be used. In this way, the converter mean time between failures can be made as high as that of the solid-state lamp. A design example for a 70-W converter supplied from a 230 V/50 Hz mains for street lighting applications is shown. Finally, experimental results from a laboratory prototype are also presented.
Isolation and characterization of four plasmids from Bacillus subtilis

Nineteen Bacillus subtilis isolates obtained from type culture collections were examined for the presence of covalently closed circular duplex deoxyribonucleic acid molecules by the technique of cesium chloride-ethidium bromide density gradient centrifugation. Four of the 19 strains tested carried covalently closed circular molecules. Two of these strains (IFO3022, IFO3215) harbored a similar plasmid with a molecular weight of 5.4 X 10(6). The other two strains (IAM1232, IAM1261) carried 4.9 C 10(6)-and 5.3 X 10(6)-dalton plasmids, respectively. These plasmid-harboring strains did not show phenotypic traits such as antibiotic resistance orbacteriocin production. The plasmid deoxyribonucleic acids were digested by three restriction endonucleases, EcoRI, HindIII, and BamNI, and were classified into three different types from their electrophoretic patterns in agarose gels.
4‐Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule‐associated protein tau

IN Alzheimer's disease (AD) the microtubule-associated protein tau is excessively phosphorylated in degenerating neurons, but the mechanisms underlying the increased phosphorylation are unknown. Recent findings suggest that oxidative stress, and membrane lipid peroxidation in particular, contributes to the neurodegenerative process in AD. We now report that following exposure of cultured rat hippocampal neurons to 4-hydroxy-nonenal (HNE), an aldehydic product of membrane lipid peroxidation, tau is resistant to dephoshorylation. Immunocytochemical and Western blot analyses using phosphorylation-sensitive tau antibodies showed that HNE treatment causes a moderate increase in basal levels of tau phosphorylation, and prevents tau dephosphorylation by alkaline phosphatase in neurons pretreated with the phosphatase inhibitor okadaic acid. Studies with anti-HNE antibodies showed that HNE binds directly to tau, and that HNE immunoreactivity localizes to cell bodies and axons, cell compartments that contain tau. These data suggest a role for HNE in altered tau phosphorylation and neurofibrillary degeneration in AD.
Contrainte de correspondance Document-Document pour la RI. Application à la Divergence de Kullback-Leibler

Cet article decrit une contrainte d'un modele de recherche d'information decrivant les comportement attendu d'un systeme si un document du corpus est pose en requete, la contrainte DDMC (Document-Document Matching Constraint). Cette contrainte n'etant pas verifiee par un modele classique de recherche d'information (modele de langue base sur un calcul de nega-tive de Divergence de Kullback-Leibler avec lissage de Jelinek-Mercer), nous presentons une modification de ce dernier modele qui permet de verifier DDMC. Une derniere partie presente des experimentations menees afin de verifier que notre modification n'impacte pas la qualite des reponses d'un systeme, tout en garantissant la verification de DDMC.
Different HLA Haplotypes in Mexican Americans With IDDM

The study of HLA histocompatibility antigens and insulin-dependent diabetes mellitus (IDDM) in non- White populations may provide a unique opportunity to more accurately define the diabetes susceptibility gene(s) located within the HLA region. To determine whether HLA haplotypes differ between ethnic groups, we compared 105 HLA haplotypes from 55 Mexican- American IDDM patients with 272 haplotypes from 136 IDDM patients of non-Hispanic White descent. The accurate determination of genotypes and haplotypes requires the study of family units. Therefore, all diabetic patients in this study were from studies of families having one or more siblings with IDDM. In the Mexican-American group, HLA-DR3 and -DR4 were the most common HLA-DR alleles and were present in comparable frequencies in the non-Hispanic White group (HLA-DR3, 27% of Mexican-American and 29% of non-Hispanic White haplotypes; DR4, 46% of Mexican- American and 43% of non-Hispanic White haplotypes). However, the HLA-B/DR-containing haplotypes and haplotype frequencies differed between the two groups. Several common haplotypes (B8/DR3, B15/DR4) in the non-Hispanic White group occurred less frequently in the Mexican-American group. In contrast, uncommon haplotypes in the non-Hispanic White group comprised nearly 50% of the DR4-containing haplotypes (B35/DR4, B40/DR4, B44/DR4) in the Mexican-American group. Although both DR3- and DR4-haplotype frequencies differed significantly between the two groups, the relative frequency of DR3- but not DR4-containing haplotypes was similar in both ethnic groups. This adds to the evidence suggesting that different susceptibilities are provided by the haplotypes carrying the DR3 and DR4 alleles.
An efficient multiple access interference suppression scheme in asynchronous femtocells

This work considers a code division multiple access (CDMA)-based femtocell system where a fixed set of subscribed users communicate simultaneously to a femtocell access point (FAP) in an asynchronous fashion during the uplink. The main goal of this paper is to present an augmentation protocol for the physical layer of the CDMA2000 femtocell standard with focus on the multiple access interference (MAI) suppression. The above-closed access femtocell uses a unique set of cyclic orthogonal binary codes to eliminate the MAI caused by packet collisions. This property ensures that the time and data rate asynchronicity of active nodes in a femtocell produces a zero MAI situation at the FAP. The work investigates the optimality and the effectiveness of such codes in femtocells from the link bit error rate performance in a practical Rayleigh-fading environment, where Kalman filtering is used at the FAP for the channel estimation. Theoretical findings are verified by simulation evaluations and it is shown numerically a significant improvement in the performance of the proposed scheme when compared with conventional non-cyclic orthogonal codes in a Rayleigh-fading channel in the asynchronous femtocell.
Maternal weight, pregnancy weight gain, and the risk of antepartum stillbirth.

OBJECTIVE This study investigated whether the risk of antepartum stillbirth increases with body mass index during early pregnancy and also investigated the association between weight gain during pregnancy and the risk of antepartum stillbirth. STUDY DESIGN This population-based case-control study included 649 women with antepartum stillbirths and 690 control subjects among Swedish nulliparous women. RESULTS Compared with lean mothers (body mass index < or = 19.9 kg/m2), the odds ratios for risk of antepartum deaths were as follows: normal weight (body mass index, 20.0-24.9 kg/m2) odds ratio, 1.2 (95% confidence interval, 0.8-1.7); overweight (body mass index 25.0-29.9 kg/m2), odds ratio, 1.9 (95% confidence interval, 1.2-2.9); and obese (body mass index > or = 30.0 kg/m2) odds ratio, 2.1 (95% confidence interval, 1.2-3.6). For term antepartum death corresponding risks were even higher, with odds ratios of 1.6 (95% confidence interval, 0.9-2.6) for normal weight, 2.7 (95% confidence interval, 1.5-5.0) for overweight, and 2.8 (95% confidence interval, 1.3-6.0) for obese women, respectively. Maternal weight gain during pregnancy was not associated with risk of antepartum stillbirth. CONCLUSION Maternal overweight condition increased the risk of antepartum stillbirth, especially term antepartum stillbirth, whereas weight gain during pregnancy was not associated with risk.