Miracle-dz/UniFAR-FTUs huggingface dataset:
SubTrack: Enabling Real-Time Tracking of Subway Riding on Mobile Devices

Real-time tracking of subway riding will provide great convenience to millions of commuters in metropolitan areas. Traditional approaches using timetables need continuous attentions from the subway riders and are limited to the poor accuracy of estimating the travel time. Recent approaches using mobile devices rely on GSM and WiFi, which are not always available underground. In this work, we present SubTrack, utilizing sensors on mobile devices to provide automatic tracking of subway riding in real time. The real-time automatic tracking covers three major aspects of a passenger: detection of entering a station, tracking the passenger's position, and estimating the arrival time of subway stops. In particular, SubTrack employs the cell ID to first detect a passenger entering a station and exploits inertial sensors on the passenger's mobile device to track the train ride. Our algorithm takes the advantages of the unique vibrations in acceleration and typical moving patterns of the train to estimate the train's velocity and the corresponding position, and further predict the arrival time in real time. Our extensive experiments in two cities in China and USA respectively demonstrate that our system can accurately track the position of subway riders, predict the arrival time and push the arrival notification in a timely manner.
Optimal Strategy for the Two-way Cooperation in International Logistics Based on Variational Method

This paper focuses on the sustainable development of international trade and international logistics, and considers the construction of the two-way cooperation system in the international logistics based on the factors of the variational method. On the basis of the logistics perspective, the paper takes into account the customer value exploration, and abstracts its essence into the procedure of "logistics cooperation". For this international logistics dynamic coordination issue, on the basis of the long-term cooperative relationship between member companies in the international logistics, this paper adopts the variational method in the continuous time background to establish the differential game model for all the international logistics parties on the two-way cooperation system of the international trade and international logistics, by solving the model, it finds that when the quasi constraint equations have solutions, Nash equilibrium exists, and thus the corresponding optimal differential game can be obtained. These theoretical findings have clarified the significance of the long-term and stable relations of cooperation for the realization of the international logistics coordination, which has certain inspiration and reference value for the implementation of the dynamic coordination of the international logistics in China. Finally, the paper makes numerical analysis on the relevant conclusion.
A Matter of Politics: The Effects of the Political Context on Social Work in Norway and Bolivia

To which extent do dysfunctional political systems lead to everyday challenges for social workers? Moreover, how do social workers benefit from working in well-ordered democracies? The purpose of this paper is to gain insights into how the interplay between the political context and social work actually operates. Our main question is: How do accountability and state capacity levels affect daily social work? This interplay frequently becomes associated with levels of democracy and redistribution. We also draw attention to how social workers’ are dependent on the capacity of the state to implement policies. We compare social work and the political and legal contexts in two widely different polities – Norway and Bolivia. Our primary findings indicate that the effects of generally unfavourable political conditions permeate the possibilities for effective social work in previously unforeseen ways. Coordination problems, clientelism and political rivalry lead to everyday challenges on the ground, as many problems seem to reflect the overall institutional system and political culture. In well-ordered political systems, these problems are hardly an issue. In our concluding discussion, we address how the nature of the institutional system and political culture apparently might call for a differentiated approach towards reform strategies. For instance, progressive politicians, citizens and social workers advocating a policy transfer could face severe hindrances in polities, thus comprising weak state capacities.
Comparison of electrical battery models using a numerically optimized parameterization method

This article describes the parameterization process of dynamic battery models for cell and system simulation. Three commonly used equivalent circuit battery models are parameterized using a numeric optimization method and basic electrical tests with a lithium-ion polymer cell. The maximum model performance is investigated and a reasonable simplification is presented. The parameterized models are then validated and compared using a current profile obtained from an electric vehicle simulation performing a real life driving cycle.
Adolescent Mice Demonstrate a Distinct Pattern of Injury after Repetitive Mild Traumatic Brain Injury.

Recently, there has been increasing interest in outcomes after repetitive mild traumatic brain injury (rmTBI) (e.g., sports concussions). Although most of the scientific attention has focused on elite athlete populations, the sequelae of rmTBI in children and young adults have not been well studied. Prior TBI studies have suggested that developmental differences in response to injury, including differences in excitotoxicity and inflammation, could result in differences in functional and histopathological outcomes after injury. The purpose of this study is to compare outcomes in adolescent (5-week-old) versus adult (4-month-old) mice in a clinically relevant model of rmTBI. We hypothesized that functional and histopathological outcomes after rmTBI would differ in developing adolescent brains compared with mature adult brains. Male adolescent and adult (C57Bl/6) mice were subjected to a weight drop model of rmTBI (n = 10-16/group). Loss of consciousness (LOC) after each injury was measured. Functional outcomes were assessed including tests of balance (rotorod), spatial memory (Morris water maze), and impulsivity (elevated plus maze). After behavioral testing, brains were assessed for histopathological outcomes including microglial immunolabeling and N-methyl-d-aspartate (NMDA) receptor subunit expression. Injured adolescent mice had longer LOC than injured adult mice compared with their respective sham controls. Compared with sham mice, adolescent and adult mice subjected to rmTBI had impaired balance, increased impulsivity, and worse spatial memory that persisted up to 3 months after injury, and the effect of injury was worse in adolescent than in adult mice in terms of spatial memory. Three months after injury, adolescent and adult mice demonstrated increased ionized calcium binding adaptor 1 (IbA1) immunolabeling compared with sham controls. Compared with sham controls, NMDA receptor subtype 2B (NR2B) expression in the hippocampus was reduced by ∼20% in both adolescent and adult injured mice. The data suggest that injured adolescent mice may show a distinct pattern of functional deficits after injury that warrants further mechanistic studies.
Metabolic Syndrome and Associated Factors in People With Chronic Obstructive Pulmonary Disease

The prevalence of metabolic syndrome (MetS) in people with chronic obstructive pulmonary disease (COPD) varies in European and Asian countries and does not always mirror the prevalence of the general population in a given country. We compared the prevalence of MetS in people with COPD with a comparison group in the United States. The National Health and Nutrition Evaluation Survey data set (2007-2010) was used to identify 94 people with COPD (mean age = 62). Data for demographic and clinical characteristics were obtained by interview and physical examination. Descriptive and inferential statistics were used to analyze the data. The prevalence of MetS was 57.5% in the COPD group and 53.6% in the comparison group. In people with COPD, the factors most significantly associated with MetS were age, income level, marital status, and respiratory symptoms. People with COPD should be screened for MetS.
The Future of Crime Reporting

Digital communication leaves traces that can lead back to the person who initiated the communication or their location at the time. Jennifer Cole and Alexandra Stickings explore the challenges this brings for platforms that claim to offer anonymous crime reporting, and ask what can be done to assure members of the public that their identity can still be protected.
Influence of Test Method on Failure Stress of Brittle Dental Materials

A bi-axial flexure test (piston-on-three-balls), a four-point flexure test, and a diametral tensile test were used to measure the failure stress of four brittle dental materials: zinc phosphate cement, body porcelain, opaque porcelain, and visible light-cured resin composite. Furthermore, the fracture probability of the bi-axial test specimens was predicted from the results of the four-point flexure test, with use of statistical fracture theory. Bi-axial failure stresses calculated from an equation developed by Marshall (1980) exhibited no significant difference for zinc phosphate cement as a function of piston size, specimen thickness, presence or absence of a stress-distributing film, and loading rate. The four-point flexure strength values of zinc phosphate cement and opaque porcelain were significantly lower (p<0.05) than the corresponding mean biaxial strength values, while the mean four-point flexure strength values of body porcelain and resin composite were not significantly lower (p>0.05) than the corresponding mean bi-axial strength values. The diametral tensile strength of all materials was significantly lower than the bi-axial flexure strength. The mean bi-axial flexure strengths of zinc phosphate cement and opaque porcelain were much higher than the theoretical values predicted from surface flaw theory, while the strength values for body porcelain and resin composite were comparable with those determined from the four-point flexure test. These results demonstrate that the strength of zinc phosphate cement depends not only upon the geometric factors, but also upon sample preparation conditions.
Doxorubicin gradients in human breast cancer.

Ten patients with locally advanced breast cancer were given doxorubicin i.v. , and an incision biopsy was subsequently taken. Doxorubicin autofluorescence was examined using computerized laser scanning microscopy, and microvessels were immunostained in the same sections. Overlays of both pictures revealed doxorubicin gradients in tumor islets with high concentrations in the periphery and low concentrations in the center of the tumor islets. Gradients were most pronounced shortly after the injection, but they could still be detected 24 h later. No gradients were observed in connective tissue. This study demonstrates a serious risk of the drug not reaching all of the cancer cells in those cases in which the cancer cells are densely packed in islets. The efficacy of drug treatment will thus depend on the histology of the tumor tissue.
Place du médecin généraliste dans la surveillance des patientes atteintes d'un cancer du sein : enquête de pratique dans le département de la Haute-Savoie

En France, le nombre de femmes en remission d’un cancer du sein ne cesse d’augmenter. Le suivi de ces patientes se voit de plus en plus confie aux medecins generalistes. Objectif : Realiser un etat des lieux de la participation des medecins generalistes du departement de la Haute-Savoie a la surveillance des patientes atteintes d’un cancer du sein et determiner si leurs pratiques sont en adequation avec les recommandations. Methode : Un questionnaire a ete envoye en octobre 2015 a 464 medecins generalistes par mail ou par courrier. Il s’agit d’une enquete de pratique declarative non remuneree et anonyme. Resultats : Le taux de participation est de 24.1 %. Cette etude illustre la feminisation, le vieillissement et l’exercice en groupe majoritaire de la population medicale du departement. 93 % des repondeurs participent au suivi. Les femmes participent plus sur le plan psychologique que les hommes et les medecins de plus de 60 ans plus sur le plan des recidives locoregionales et metastatiques. Le taux moyen de bonnes reponses est de 47 % sans difference significative entre le sexe, l’âge et le mode d’exercice. 29 % des generalistes continuent a prescrire des examens complementaires de suivi non recommandes apres 5 ans, plus souvent des medecins âges de plus de 60 ans. 91 % des repondeurs sont interesses par la diffusion d’une fiche de synthese des recommandations d’experts. Conclusion : L’implication du medecin generaliste dans le suivi des patientes atteintes d’un cancer du sein est majeure mais les pratiques sont heterogenes et les recommandations ne sont pas largement appliquees. Cette etude souligne la necessite de renforcer la formation continue sur ce sujet.
Numb-deficient satellite cells have regeneration and proliferation defects

Significance This study discloses a role for Numb in the activation and proliferation of adult muscle satellite cells and a unique function in the regulation of the muscle mass determinant Myostatin. Using two different genetic approaches to ablate Numb, one that ablated Numb in the myogenic lineage developmentally leading to reduced muscle mass. We determined that, in Numb-deficient muscle, regeneration was impaired, there was reduced stem cell proliferation, and there was an up-regulation of Myostatin. Overexpression of Numb suppressed Myostatin expression, and Myostatin-specific siRNA rescued the proliferation defect. These studies increase our knowledge of the signaling pathways involved in stem cell function and raise the possibility of regulating the Numb/Myostatin balance as a therapeutic approach to enhance muscle regeneration. The adaptor protein Numb has been implicated in the switch between cell proliferation and differentiation made by satellite cells during muscle repair. Using two genetic approaches to ablate Numb, we determined that, in its absence, muscle regeneration in response to injury was impaired. Single myofiber cultures demonstrated a lack of satellite cell proliferation in the absence of Numb, and the proliferation defect was confirmed in satellite cell cultures. Quantitative RT-PCR from Numb-deficient satellite cells demonstrated highly up-regulated expression of p21 and Myostatin, both inhibitors of myoblast proliferation. Transfection with Myostatin-specific siRNA rescued the proliferation defect of Numb-deficient satellite cells. Furthermore, overexpression of Numb in satellite cells inhibited Myostatin expression. These data indicate a unique function for Numb during the initial activation and proliferation of satellite cells in response to muscle injury.
Long-circulating vectors for the systemic delivery of genes.

The development of vectors capable of treating systemic diseases is an important goal for gene therapy protocols. In order for a carrier system to preferentially accumulate at sites of systemic disease, such as tumors, sites of inflammation and sites of infection, the carrier must exhibit long circulation lifetimes following intravenous injection. Unfortunately, most gene delivery systems, including viral vectors as well as non-viral vectors, e.g., lipoplexes, polyplexes and lipopolyplexes, are rapidly cleared from the circulation and are preferentially taken up by the 'first-pass' organs such as liver, lung and spleen. Here we review recent literature concerning the ability of non-viral vectors to act as systemic gene therapy agents. The most promising systemic vectors are liposomal systems in which plasmid DNA is encapsulated within a lipid bilayer. The stabilized plasmid-lipid particle (SPLP) system, for example, exhibits circulation half-lives of the order of 6 h following intravenous injection, and preferentially accumulates in distal tumors with gene expression primarily localized to the tumor site.
Protein Kinase G Type Iα Activity in Human Ovarian Cancer Cells Significantly Contributes to Enhanced Src Activation and DNA Synthesis/Cell Proliferation

Previously, we showed that basal activity of nitric oxide (NO)/cyclic GMP (cGMP)/protein kinase G (PKG) signaling pathway protects against spontaneous apoptosis and confers resistance to cisplatin-induced apoptosis in human ovarian cancer cells. The present study determines whether basal PKG kinase activity regulates Src family kinase (SFK) activity and proliferation in these cells. PKG-Iα was identified as predominant isoform in both OV2008 (cisplatin-sensitive, wild-type p53) and A2780cp (cisplatin-resistant, mutated p53) ovarian cancer cells. In both cell lines, ODQ (inhibitor of endogenous NO-induced cGMP biosynthesis), DT-2 (highly specific inhibitor of PKG-Iα kinase activity), and PKG-Iα knockdown (using small interfering RNA) caused concentration-dependent inhibition of DNA synthesis (assessed by bromodeoxyuridine incorporation), indicating an important role of basal cGMP/PKG-Iα kinase activity in promoting cell proliferation. DNA synthesis in OV2008 cells was dependent on SFK activity, determined using highly selective SFK inhibitor, 4-(4′-phenoxyanilino)-6,7-dimethoxyquinazoline (SKI-1). Studies using DT-2 and PKG-Iα small interfering RNA revealed that SFK activity was dependent on PKG-Iα kinase activity. Furthermore, SFK activity contributed to endogenous tyrosine phosphorylation of PKG-Iα in OV2008 and A2780cp cells. In vitro coincubation of recombinant human c-Src and PKG-Iα resulted in c-Src–mediated tyrosine phosphorylation of PKG-Iα and enhanced c-Src autophosphorylation/activation, suggesting that human c-Src directly tyrosine phosphorylates PKG-Iα and the c-Src/PKG-Iα interaction enhances Src kinase activity. Epidermal growth factor–induced stimulation of SFK activity in OV2008 cells increased PKG-Iα kinase activity (indicated by Ser239 phosphorylation of the PKG substrate vasodilator-stimulated phosphoprotein), which was blocked by both SKI-1 and SU6656. The data suggest an important role of Src/PKG-Iα interaction in promoting DNA synthesis/cell proliferation in human ovarian cancer cells. The NO/cGMP/PKG-Iα signaling pathway may provide a novel therapeutic target for disrupting ovarian cancer cell proliferation. Mol Cancer Res; 8(4); 578–91. ©2010 AACR.
Gestational Effects of Corticosteroids and Surfactant in Ventilated Rabbits

ABSTRACT: Maternal corticosteroid treatments decreased lung protein leaks and increased the compliance responses to exogenous surfactant in 27-day preterm rabbits. We asked if maternal corticosteroid treatments at different gestational ages might alter these responses. Pregnant does were given 0.1 mg/kg betamethasone 48 and 24 h before study of the rabbits at 27, 28, and 29 days of gestational age and term newborns at 31 days of gestational age. Alternate rabbits at each gestation were treated with 50 mg/kg surfactant after delivery. Alveolar saturated phosphatidylcholine pool sizes increased with gestation similarly in control and corticosteroid-treated groups. Corticosteroids improved compliance relative to control values at 29 days of gestational age in animals not treated with surfactant and improved the compliance response to surfactant treatment at 27 and 28 days of gestational age. Corticosteroids decreased the leak of radiolabeled albumin to the lungs and alveolar washes at all preterm gestations with a maximum decrease to 16% of the control value at 29 days of gestation. Surfactant decreased this protein leak more effectively than did corticosteroids at the earlier gestations. There were potentially beneficial effects of corticosteroids either alone or together with surfactant at all preterm gestations studied. No protein leak or compliance effects of either treatment were noted in the term newborns.
Give Away Your Digital Services

OVERVIEW: Consumers are getting used to receiving free services in many different fields, and the popularity of the mobile app industry is feeding this phenomenon. Historically, advertising—a typical two-sided market mechanism—is the primary method that companies relying on a free-to-consumers business model have used to appropriate value in digital environments. But new strategies are needed to make free services sustainable and profitable in the long term. At the same time, companies are gathering a huge amount of data from consumers, especially through mobile apps, by leveraging the sensors embedded in smartphones; this data represents a powerful new source of value. Through a case study analysis, we show how leveraging a two-sided structure can enable companies to capture value from user-sourced data, enabling a sustainable free-to-consumers business model. In this model, users are more than eyeballs to be targeted with advertising; they become data providers, and companies may capture value by using that data to customize advertising messages, leverage e-ethnography to improve their own core offer, serve as fodder for research, or create knowledge for third parties.
[Hepatitis C viruses infection situation in the human population of six provinces in China].

OBJECTIVE To investigate the seroprevalence of hepatitis C viruse infection in the human population in six regions of Beijing, Heilongjiang, Shandong, Ningxia, Gansu and Sichuan in China. METHODS ELISA was used for detecting anti-HCV IgG of the serum samples. All sample were collected in 2006-2008 in six areas. RESULTS 9538 samples were detected. The total positive rate of anti-HCV was 0.39% (37), 0.23% (3/1328) in Beijing, 0.74% (12/1629) in Heilongjiang, 0.26% (5/1962) in Shandong, 0.1% (1/1000) in Ningxia, 0.44% in Gansu (9/2 037) and Sichuan (7/1582), respectively. The 37 positive samples at the sex were 19 (51.35%) of man and 18 (48.65%) of female. At the age group were 1 (2.70%) of < 10 years old, 5 (13.51%) of 10-19 years old, 4 (10.81%) of 20-29 years old, 6 (16.22% ) of 30-39 years old, 9 (24.32%) of 4049 years old, 12 (32.43%) of > or = 50 years old. The positive samples were detected anti-HAV-IgG, anti-HEV-IgG and HBsAg/ HBcAb /HBeAb. The positive Number was 35 (94.59%), 10 (27.03%) and 2 (5.41%) respectively. CONCLUSIONS HCV infection rate in the population was 0.1% -0.74%, 1/3 of > or = 50 years old in HCV positive. Hepatitis C virus co-infection with HAV, HEV and HBV.
Non-instantaneous deterioration inventory model with price and stock dependent demand for fully backlogged shortages under inflation

In this paper we have developed an inventory model according to consideration of price, stock dependent, fully backlogged shortage and inflation. In this model we have described the demand function is dependent on price and stock and in shortage time the demand is depend only price of the product. Price of the product is dependent on different markup rate. The deterioration is considered as a non-instantaneous, i.e., when the item stock in retailer's house after some time deterioration will start. Shortages, if any are allowed and it is fully backlogged. The corresponding inventory problem constitutes a constraint optimisation problem. Here we have solved this problem by using Lingo 10 software. Finally, to illustrate and validate the inventory model, we have used a numerical example considered different markup rate. A sensitivity analysis has been carried out to study the effect of changes of different inventory parameters changing one parameter at a time and the others value of parameters is same.