Miracle-dz/UniFAR-FTUs huggingface dataset:
Acteurs et mécanismes des bio-transformations de l'arsenic, de l'antimoine et du thallium pour la mise en place d'éco-technologies appliquées à la gestion d'anciens sites miniers

Les dechets sulfures issus de l’extraction des minerais metalliques generent des drainages miniers acides (DMA), contenant des elements toxiques tels que l’arsenic (As), l’antimoine (Sb) et le thallium (Tl). Des procedes de remediation utilisant des communautes microbiennes ont ete developpes afin d’eliminer ces polluants des DMA, mais les processus biologiques en jeu dans ces traitements doivent encore etre maitrises pour garantir leur efficacite. Les verrous scientifiques, objets de la these, resident dans (1) la meconnaissance des transformations microbiennes, directe et indirectes, de Sb et Tl, et, (2) pour l’As, la faible comprehension des relations qui existent entre la dynamique des communautes microbiennes, leur potentiel fonctionnel, la physico-chimie des eaux et l’efficacite des traitements appliques aux DMA. Une approche pluridisciplinaire, principalement basee sur des outils d’ecologie microbienne et de physico-chimie, a permis de caracteriser la diversite des communautes microbiennes capables de transformer directement ou indirectement As et Sb, a differentes echelles experimentales : reacteur batch, dispositif a flux continu de laboratoire et pilote de terrain. Un consortium microbien capable de tolerer jusqu’a 100 mM d’antimonite et de l’oxyder en conditions acides (pH < 4), equivalentes a celles des DMA, a ete obtenu a partir d’un sol contamine au Sb. Un bioreacteur colonne de laboratoire, alimente en continu avec un DMA reel et inocule avec un consortium bacterien sulfato-reducteur issu de ce DMA, a permis l’elimination de la quasi-totalite de l’As, du Sb et du Tl presents dans l’eau. Enfin, la dynamique des communautes bacteriennes au sein d’un dispositif aerobie de traitement d’un DMA riche en As installe sur site a ete decrite. Ces communautes sont dominees par des bacteries Fe-oxydantes, et les modifications spatiales et temporelles de leur structure apparaissent associees aux variations de la physico-chimie de l’eau (concentration en oxygene dissous, temperature, pH, potentiel redox, concentrations en sulfate, arsenic et fer(II)). Les connaissances acquises au cours de cette these pourront servir de base a la conception d’eco-technologies passives et peu couteuses applicables a la gestion et la remediation d’anciens sites miniers.
Cardiovascular and mental health benefits of soy consumption: role of soy isoflavones.

s and Conference Presentations Thorp A, Sinn N, Buckley J, Coates A & Howe P. Soy Isoflavone Supplementation Improves Spatial Working Memory in Healthy Males. Nutrition Societies of New Zealand and Australia Annual Scientific Meeting. Asia Pac J Clin Nutr 2007; 16 (Suppl 3): S34. Thorp A, Buckley J, Coates A, Mori T, Hodgson J, Mansour J, Howe P and Meyer B. Importance of soy protein and isoflavone intake for protection against heart disease. NSA Annual Scientific Meeting. Asia Pac J Clin Nutr 2006;15(Suppl 3): S47. Awarded Best Student Oral Presentation; Nutrition Society of Australia (NSA), 30th Annual Scientific Meeting, 29 November 2006 Sydney Thorp A, Morris A, Buckley J, Mori T, Hodgson J, Meyer B & Howe P. Lack of effect of soy diets on LDL cholesterol. ASMR SA Divn. Annual Scientific Meeting, 2006; pg 57 (Poster Presentation) Thorp A, Morris A, Buckley J, Mori T, Hodgson J, Meyer B & Howe P. Lipid lowering effects of foods containing soy protein and isoflavones. ASMR SA Divn. Annual Scientific Meeting, 2005; abstr. O20 Awarded Healthy Aging Research Cluster (HARC) and Australian Society of Medical Research (ASMR) Healthy Ageing Research Prize for best oral presentation; ASMR Annual Scientific Meeting, 15 June, 2005.
Abnormal threshold voltage shift caused by trapped holes under hot-carrier stress in a-IGZO TFTs

In the investigation of the reliability of a back-channel-etching type amorphous InGaZnO thin film transistor, we found that hot carrier stress has caused an abnormal parallel negative threshold voltage shift in the ID–VG measurement. An electrical measurement method named drain stress was established to investigate this instability. Through the analysis of recovery behavior, gate bias stress and Silvaco simulation, we confirmed that holes from the drain side inject into the passivation layer and/or back-channel interface region rather than into the gate insulator under the transverse electric field. A physical model is proposed to verify this electrical degradation behavior. This work demonstrates that drain stress is valuable in examining the quality of the passivation layer in thin film transistors.
Kemoterapeutikumok, terápiás válasz és reziztencia-mechanizmusok a colorectalis carcinoma kezelésében.

Colorectal carcinoma is one of the most common cancers in Hungary, responsible for about 5000 deaths each year. In the first line treatment the most commonly used drugs are 5-fluorouracil, oxaliplatin and irinotecan. The most frequently used drug is 5-fluorouracil, which has no effect in 90% of the cases. In combination with leukovorin or with 5-ethyl-2'-deoxyuridin fluorouracil has an increased effect. The main mechanisms of the resistance against 5-fluorouracil are due to the overexpression of dihydropyrimidine dehydrogenase, MRP8, thymidylate synthase, and NFkB p65. Oxaliplatin forms reactive platinum complexes, which are believed to inhibit DNA synthesis by forming interstrand and intrastrand cross-linking of DNA molecules. The oxaliplatin-5-fluorouracil-leucovorin combination was the first to reach more than 20 months median survival. The main mechanisms of resistance are decreased accumulation, increased detoxification and increased DNA repair. Irinotecan inhibits the topoisomerase I enzyme, resulting in the inhibition of the repair of DNA breaks occurring during DNA synthesis. With sequential 5-fluorouracil, oxaliplatin, irinotecan combination 26 months median survival was reached. Mechanisms resulting in resistance are decreased accumulation, increased enzymatic detoxification, alterations of ABC transporters, DNA repair system, apoptotic pathways and topoisomerase I. Survival can be elongated using biological therapy (cetuximab, bevacizumab). In the near future biological therapy is expected to spread.
Zum möglichen antimikrobiellen Einfluss von Zahnpasten

420 Der Leser sollte nach dem Durcharbeiten des Artikels Folgendes wissen: ▪Hinsichtlich der Behandlungskosten chronischer Erkrankungen steht die Karies weltweit an 4. Stelle. ▪ Ein Kariesrückgang in westlichen Industriestaaten beruht auf der Verwendung fluoridierter Zahnpasten (ZP). ▪Hoher Zuckerkonsum setzt der remineralisierenden Wirkung von Fluorid Grenzen. ▪ Zahnpasten enthalten auch antimikrobielle Wirkstoffe. ▪ In-vitro-Untersuchungen bestätigen den antimikrobiellen Effekt von Zahnpasten.
Population genetic structure and predominance of cyclical parthenogenesis in the bird cherry‐oat aphid Rhopalosiphum padi in England

Genetic diversity is the determinant for pest species’ success and vector competence. Understanding the ecological and evolutionary processes that determine the genetic diversity is fundamental to help identify the spatial scale at which pest populations are best managed. In the present study, we present the first comprehensive analysis of the genetic diversity and evolution of Rhopalosiphum padi, a major pest of cereals and a main vector of the barley yellow dwarf virus (BYDV), in England. We have used a genotyping‐by‐sequencing approach to study whether (a) there is any underlying population genetic structure at a national and regional scale in this pest that can disperse long distances; (b) the populations evolve as a response to environmental change and selective pressures; and (c) the populations comprise anholocyclic lineages. Individual R. padi were collected using the Rothamsted Insect Survey's suction‐trap network at several sites across England between 2004 and 2016 as part of the RIS long‐term nationwide surveillance. Results identified two genetic clusters in England that mostly corresponded to a North–South division, although gene flow is ongoing between the two subpopulations. These genetic clusters do not correspond to different life cycle types, and cyclical parthenogenesis is predominant in England. Results also show that there is dispersal with gene flow across England, although there is a reduction between the northern and southern sites with the south‐western population being the most genetically differentiated. There is no evidence for isolation by distance and other factors such as primary host distribution, uncommon in the south and absent in the south‐west, could influence the dispersal patterns. Finally, results also show no evidence for the evolution of the R. padi population, and it is demographically stable despite the ongoing environmental change. These results are discussed in view of their relevance to pest management and the transmission of BYDV.
Comparison of Outcomes between Endoscopic and Transcleral Cyclophotocoagulation

Importance: Traditionally cyclophotocoagulation has been reserved as a treatment of last resort for eyes with advanced stage glaucoma, but increasingly it is offered to eyes with less severe disease. Endoscopic approaches in particular are utilized in increasing numbers of patients despite only a small number of publications on its results. Objective: The purpose of this study was to compare the efficacy and safety of endoscopic and transcleral cyclophotocoagulation (ECP and TCP) procedures in eyes with refractory glaucomas. Design, Setting, and Participants: A chart review was performed on consecutive patients who underwent ECP and TCP at a tertiary ophthalmology care center between January 2000 and December 2010. Cases with fewer than 3 months of follow-up or that had concurrent pressure reducing procedures were excluded. The main outcome measures examined were intraocular pressure (IOP), number of glaucoma medications, best corrected visual acuity (BCVA), additional glaucoma procedure required, and complications. Main Outcomes and Measures: Forty-two eyes (42 patients) that underwent ECP and forty-four eyes (44 patients) that underwent TCP were identified. The TCP group had a statistically higher mean age (71.2 ± 16.7 vs. 58.1 ± 22.9 years, respectively), larger proportion of neovascular glaucoma (40.9% vs. 16.7%), worse initial BCVA (logMAR 2.86 vs. 1.81), and higher preoperative IOP (45.3 vs. 26.6 mmHg) than the ECP group. At 12 months follow-up, the mean IOP difference between groups was not statistically significant, although the change in IOP from baseline to 12 months was greater for the TCP group (p = 0.006). The rates of progression to no light perception (NLP) and phthisis bulbi were significantly higher amongst TCP eyes than ECP eyes (27.2% vs. 4.8%, p = 0.017, and 20.5% vs. 0%, p = 0.003, respectively). Of these eyes that progressed, a majority had neovascular glaucoma (NVG). Corneal decompensation was the most frequent complication following ECP (11.9%). Conclusions and Relevance: In patients with preoperative BCVA of 20/400 or better, overall complication rates (cystoid macular edema, exudative retinal detachment, inflammation, cornea decompensation) were higher after ECP than with TCP. In refractory glaucomas in a real world setting (not a trial), TCP was more frequently used in ischemic eyes. TCP was associated with a higher rate of progression to phthisis bulbi and loss of light perception than ECP. However, ECP was associated with a clinically significant rate of corneal decompensation. These outcomes likely were related to the severity of underlying ocular diseases found in these eyes.
Patognomonik CA 19-9 yüksekliğine sebep olan dalak kisti olgusu

CA 19-9 safra kanali, kolon, mide, over, hepatoselluler, ozofagus ve pankreas kanserleri gibi malign durumlarda yuksek seviyelerde gorulebilen bir tumor gostergesidir. Pankreas kanseri ayirici tanisi ve yine pankreas kanserinde tedaviye cevap ve nuksun degerlendirilmesinde kullanilir. Yuksek seviyeler safra yolu obstruksiyonu, kolanjit, inflamatuvar barsak hastaligi, akut veya kronik pankreatit, karaciger sirozu, kistik fibrozis ve tiroid hastaliklari gibi benign durumlarda da gorulebilir. CA 19- yuksekligi ile birlikte olan nadir bir durum da dalak kistleridir. Olgumuz nadir olmasi ve CA 19-9‘un yayinlanilan benzer olgulardan yuksek seviyelerde olmasi sebebiyle sunulmustur.
Diagnosis of Papillary Thyroid Cancer via Detection of BRAF Mutation on Fine Needle Aspiration Cytology Slides

Purpose: The prevalence rate of the BRAF mutation in papillary thyroid cancer (PTC) is as high as about 52 to 83% in Korea. Preoperative detection of BRAF mutation on fine needle aspiration cytology (FNAC) slides may help the surgeon make better therapeutic decisions. The present study aims to assess the feasibility of the mutant allele specific amplification (MASA) and restriction fragment length polymorphism (RFLP) method with using conventional FNAC slides and we also wanted to evaluate the clinical role of preoperatively detecting BRAF mutation. Methods: We extracted the genomic DNA from 59 FNAC slides and performed direct sequencing (DS) for detecting BRAF mutation. We could use only 17 slides for the MASA method and 6 slides for the RFLP method due to the shortage of extracted DNA. Additionally, we retrospectively analyzed the cases for which a histological diagnosis could be made. Results: Genomic DNA was extracted from 23 out of the 59 FNAC slides. The BRAF mutation status could be assessed via DS in 33 out of the 59 FNAC slides. The concordance between the MASA method and DS and the RFLP method and DS was 36.3% and 66.7% respectively. The positive and negative predictive value of the 13 indeterminate nodules was 87.5% and 20%, respectively. We could not find any association between the BRAF mutations and the alleged risk factors of PTC. Conclusion: We believe that the purity and the amount of the DNA template must be increased to detect BRAF mutation with using a FNAC slide. Preoperative detection of the BRAF mutation on a FNAC slide may refine the cytological diagnosis, but the application of assessing BRAF mutation as a prognostic marker is debatable. (Korean J Endocrine Surg 2010;10:12-18)
Long-term Effectiveness and Tolerability Profile of Iloperidone in Patients of Psychosis

Aim: To evaluate the long-term efficacy, tolerability, and safety profile of iloperidone. Materials and methods: A 12 month, prospective, interventional, open label, flexible dose study was conducted on 50 drug naïve, first-episode patients aged 18 to 65 years, fulfilling the International Classification of Diseases-10 criteria for psychosis, for assessing long-term efficacy and adverse events, including biochemical parameters of iloperidone. Detailed clinical examination was carried out. Sociodemographic data and baseline parameters were recorded. Results: Two patients dropped out during the course of therapy. M/F ratio was 1.77:1. Mean age of patients was 28.76 ± 10.28 [mean ± standard deviation (SD)] years. Rural/urban ratio was 2.84:1.25. Patients were illiterate, 18 belonged to low socioeconomic class. It was observed that iloperidone was fairly efficacious not only in preventing relapse or aggravation of symptoms but also well restored the patient to almost near-normal till the end point. After 3 months, 20/48 (41.66%) patients showed significant weight gain that was evident. Mean total weight gain from baseline to end point was 2.89 kg and was statistically significant. There was significant rise in body mass index (BMI) but no patient crossed the upper normal limit. Iloperidone did not cause significant rise (p < 0.6955) in fasting blood sugar (FBS), and no significant alterations in total cholesterol (TC), triglyceride, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol were recorded. Dizziness was one of the earliest adverse events appearing within 2 to 3 days; others were insomnia, weight gain, increased appetite, anxiety, headache, sedation, etc. Conclusion: On long-term basis, iloperidone is fairly efficacious and has favorable tolerability profile with modest weight gain and practically no alteration in FBS, and lipid profile as well as absence of extrapyramidal side effects.
Determining the Ecological Compensation Standard Based on Forest Multifunction Evaluation and Financial Net Present Value Analysis: A Case Study in Southwestern Guangxi, China

ABSTRACT There is growing concern that public benefits from forests are underprovided in current forest management regimes and need to be increased through policy and economic measures that promote conservation. Ecological compensation is a type of institutional arrangement for the sustainable use of ecosystem services achieved by adjusting the distribution of costs and benefits among different stakeholders using economic measures. However, how to accurately and reasonably determine the compensation standard for ecological services has not been guided by scientific methods and theories. This study provides an estimation of the compensation standard for forest ecological services based on the forest multifunction evaluation and financial net present value analysis, and a case study was performed in Southwest China. The results showed that most forest types brought some economic loss to the managers but contributed great ecological benefits to the public when they were managed as ecological forests. It is crucial to incentivize forest managers to participate in voluntary conservation programs through ecological compensation. The results of this analysis can potentially guide sustainable forest management by both accurate quantification of the value of forest ecosystem services and an improved understanding of the costs of voluntary forest conservation schemes currently in use in many countries.
Optimization of scale-up of KNLN piezocomposites: for flexible haptic feedback applications

In this thesis, we focus on flexible haptic feedback applications which rely on the sensation of touch to display a feedback to the user that establishes a system to user interaction. Piezocomposites made of piezoceramic and polymer phases can be used here due to their high flexibility and piezoelectric properties that enable them to deform under an electric field. A lead-free piezoceramic: KNLN-3 has been chosen as the ceramic phase due to lead-based ceramics having issues with toxicity and dielectric mismatch in composites. A flexible polymer: CFE was chosen as the polymer phase due to its high dielectric constant that decreases the dielectric mismatch to the maximum extent. The first objective of this thesis is to optimize the scale-up in production of KNLN-3 when employed as a random 0-3 composite. Thus, the production of KNLN-3 was analyzed with respect to the microstructure, purity, surface topology, poling, lithium content, precursors used and correlated with its performance in a composite. Based on this set of data, an optimized powder was obtained. The second objective of thesis was to perform mechanical tests on a composite made with this powder to obtain mechanical properties that quantify its effectiveness as a flexible haptic feedback device. From these tests, the optimized powder was seen to be the most ideal when it was employed as an R50 (0-3 composite with 50 % filler) composite with no glass fibres used during production.
Knowledge Management Practices in Textile Industry : An Analytical Study

Rajneesh Research Scholar, Department of Commerce (Kurukshetra University, Kurukshetra) Abstract The textile and clothing industry is vital for the Indian economy by way of its impulse contribution to the GDP, industrial output, and employment generation. The State, Haryana with its strong existing infrastructure for textiles, skilled labor, abundant supply of raw material and strategic location ideally positioned to benefit from this opportunity. Through an innovative strategy and targeted interventions, the textiles industry in the state can attain growth, buoyed by both increased domestic consumption and growth in exports. Knowledge has become one of the most important driving forces for business success. Knowledge management helps organizations to find, select, categorize, distribute, and transfer vital information within the organization. The present study based on primary data. It describes the knowledge management practices adopted by the textile industry of Haryana.
Primary Headaches and their Relationship with the Autonomic Nervous System

Headache disorders, described as early as 3000 BC, represent both a treatment challenge and a serious public health concern, with impact on the individual and society. Existing research in primary headache syndromes (not being caused by any underlying problem) focuses mainly on pain mechanisms. However, the painful symptomatology is the main encounter for the decreased quality of life and discomfort, the vegetative manifestations that frequently accompany the cephalalgic syndromes represent an important source of distress. Despite the advancement of the understand‐ ing of the molecular basis of headache disorders and neurovascular complex interactions, there is still lack of a cohesive understanding of the neurovegetative modulation in different types of primary cephalalgic syndromes. The aim of this chapter is to present an overview of the neurochemical mechanisms and pathways, which subtend dysautonomic manifestations in headache. manifestations of the headaches are provoked by the tight connections between the pain receptors located at the head level and the autonomic structures of the central system. The primary cephalalgic syndromes with vascular implications (migraine, cluster headache, SUNCT, and paroxysmal hemicrania) present intricate patho‐ genic mechanisms, involving autonomic centers of the brain stem. Therefore, headache's complex manifestations must be understood based on anatomical and physiological correla‐ tions with pain sensitive structures of the cranium. aggressiveness, depression, and
ANALYSIS OF CHANGE IN NT-proBNP AFTER ANGIOTENSIN RECEPTOR BLOCKER (ARB) THERAPY IN PATIENT WITH HEART FAILURE

NT-proBNP is an inactive fragment of BNP secreted by stretched ventricle as response to wall stress in patients with heart failure. As a specific cardiac marker, elevated NT-proBNP correlates well with heart failure severity. The principle of heart failure therapy is modulation on neurohormonal activation. ARB can modulate neurohormon on RAA system, that result in decreasing NT-proBNP level and favorable outcomes. Reduction in NT-proBNP more than biologic variability (> 25%) shows a therapy response.This study was to analyze change of NT-proBNP after ARB therapy in ambulatory HF patients. This observational prospective study was carried from September to December 2015. Blood sampling was performed on patients who meet the inclusion criteria of the study at first visit and after 2 months therapy. NT-proBNP was measured by IMMULITE® as primary parameter and creatinin as secondary parameter. There are 14 patients met the inclusion criteria of the study (11 males and 3 females). ARB therapy used in patients were Valsartan (64%), Telmisartan (22%) and Candesartan (14%). After 2 months ARB therapy, a decrease in level of NT-proBNP with initial median 3092.5 (216 – 32112) pg/ml to 2135.5 (350 – 16172) pg/ml respectively were statistically significant (p=0.003). And the secondary parameter creatinin serum convert to eGFR shows a change in eGFR with initial median 73.33 (37.05 – 266.68) ml/minute to 81.04 (39.31 – 167.02) ml/minute respectively were statistically not significant (p=0.657). There were 7 patients (50%) have a decrease > 25%. In this study, we found that ARB therapy can change NT-proBNP level significantly after 2 months therapy.