Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Distance on Sentence Processing by Older Adults

In sentences with long-distance dependency relations (“The man whom the police arrested is thin”), there are two kinds of distance between the gap (object position of arrested) and the filler man: linear (the intervening words in linear order), and structural (the intervening nodes in the syntactic tree). Previous studies found that older adults have difficulty comprehending sentences with long-distance dependency relations. However, it is not clear whether they are more disrupted by longer structural distance between gaps and fillers, or longer linear distance. There is a distinction between linear distance and structural distance, in that the former is directly related to working memory whereas the latter is associated with syntactic ability. By examining the effect of linear distance and structural distance on sentence processing by older adults, we can identify whether age-related decline in sentence comprehension is attributed to working memory dysfunction or syntactic decline. For this purpose, structural distance and linear distance were manipulated in Mandarin relative clauses (RCs). 30 older adults and 33 younger adults were instructed to perform a self-paced reading task. We found that both groups performed more slowly as structural distance increased, and less accurately when linear distance increased. More importantly, there was a significant interaction between linear distance and age group in the accuracy of comprehension, with linear distance disrupting older adults more than younger adults in offline processing. The findings suggest that the age-related decline in offline sentence comprehension might be attributable to the decline in working memory, rather than syntactic ability. Practical implications, limitations, and directions for future studies are discussed.
Model Projections in Model Space: A Geometric Interpretation of the AIC Allows Estimating the Distance Between Truth and Approximating Models

Information criteria have had a profound impact on modern ecological science. They allow researchers to estimate which probabilistic approximating models are closest to the generating process. Unfortunately, information criterion comparison does not tell how good the best model is. In this work, we show that this shortcoming can be resolved by extending the geometric interpretation of Hirotugu Akaike’s original work. Standard information criterion analysis considers only the divergences of each model from the generating process. It is ignored that there are also estimable divergence relationships amongst all of the approximating models. We then show that using both sets of divergences and an estimator of the negative self entropy, a model space can be constructed that includes an estimated location for the generating process. Thus, not only can an analyst determine which model is closest to the generating process, she/he can also determine how close to the generating process the best approximating model is. Properties of the generating process estimated from these projections are more accurate than those estimated by model averaging. We illustrate in detail our findings and our methods with two ecological examples for which we use and test two different neg-selfentropy estimators. The applications of our proposed model projection in model space extend to all areas of science where model selection through information criteria is done.
Movement of moths through riparian reserves within oil palm plantations

Tropical forests are becoming increasingly fragmented through conversion to agriculture, with negative consequences for biodiversity. Movement of individuals among the remaining fragments is critical to allow populations of forest-dependent taxa to persist. In SE Asia, conversion of forests to oil palm plantations is a particular threat. Many oil palm dominated landscapes retain forested riparian reserves along streams and rivers, but the extent to which these riparian reserves are used for movement, relative to the oil palm matrix, is poorly understood. We used mark-release-recapture methods to investigate the movement of five moth taxa in riparian reserves connected to a continuous forest area within oil palm matrix in Sabah, Malaysian Borneo. Moths were recaptured on average 68m from the release point, and the mean time to recapture was between 2 and 3 days. Moths showed a significant tendency to move within forested riparian reserves than into adjacent oil palm. When moving within riparian reserves moths also showed a tendency to orient their movement away from the continuous forest into the riparian reserve rather than towards continuous forest or into oil palm. Overall, our results show a role for riparian reserves as movement corridors through oil palm plantations for some invertebrate species, strengthening the case for their retention and re-establishment.
Re-innervation of the Denervated Dentate Gyrus by Sprouting Associational and Commissural Mossy Cell Axons in Organotypic Tissue Cultures of Entorhinal Cortex and Hippocampus

Collateral sprouting of surviving axons contributes to the synaptic reorganization after brain injury. To study this clinically relevant phenomenon, we used complex organotypic tissue cultures of mouse entorhinal cortex (EC) and hippocampus (H). Single EC-H cultures were generated to analyze associational sprouting, and double EC-H cultures were used to evaluate commissural sprouting of mossy cells in the dentate gyrus (DG) following entorhinal denervation. Entorhinal denervation (transection of the perforant path) was performed at 14 days in vitro (DIV) and associational/commissural sprouting was assessed at 28 DIV. First, associational sprouting was studied in genetically hybrid EC-H cultures of beta-actin-GFPtg and wild-type mice. Using calretinin as a marker, associational axons were found to re-innervate almost the entire entorhinal target zone. Denervation experiments performed with EC-H cultures of Thy1-YFPtg mice, in which mossy cells are YFP-positive, confirmed that the overwhelming majority of sprouting associational calretinin-positive axons are mossy cell axons. Second, we analyzed associational/commissural sprouting by combining wild-type EC-H cultures with calretinin-deficient EC-H cultures. In these cultures, only wild-type mossy cells contain calretinin, and associational and commissural mossy cell collaterals can be distinguished using calretinin as a marker. Nearly the entire DG entorhinal target zone was re-innervated by sprouting of associational and commissural mossy cell axons. Finally, viral labeling of newly formed associational/commissural axons revealed a rapid post-lesional sprouting response. These findings demonstrate extensive and rapid re-innervation of the denervated DG outer molecular layer by associational and commissural mossy cell axons, similar to what has been reported to occur in juvenile rodent DG in vivo.
Editorial: Bioactive Phytochemicals in Asteraceae: Structure, Function, and Biological Activity

1 Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stanković, University of Belgrade, National Institute of Republic of Serbia, Belgrade, Serbia, 2 Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece, 3 Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança Campus Santa Apolónia, Bragança, Portugal
Saharan Dust Modeling Over the Mediterranean Basin and Central Europe: Does the Resolution Matter?

The Mediterranean Basin is frequently affected by desert dust outbreaks coming from the north of Africa. The presence of this type of particulate matter (PM) joint to others (in particular, anthropogenic pollution from the intense human activities) makes the air quality over this region a worrying issue. In this sense, an accurate characterization of the dust transport is essential. This study tries to shed some light on the sensitivity of dust modeling to the spatial resolution by using the online integrated meteorological-chemical model (WRF-Chem). Three simulations only differing on spatial resolution (D1 at 1.32$^\circ$, D2 at 0.44$^\circ$ and D3 at 0.11$^\circ$), during a representative omega-blocking situation over Europe causing Saharan dust transport over the Mediterranean and central Europe were evaluated against MODIS and AERONET. This evaluation revealed an improvement in the model AOD representation when resolution becomes finer, specially over the Saharan desert dust affected area. These discrepancies between resolutions could be attributed to changes both in thermodynamics and dynamics, since AOD is sensitive to aerosol mass, size distribution and water uptake. Relative humidity (RH) and PM-ratio (PM$_{2.5}$/PM$_{10}$) present non-local differences due to the increase of the resolution as a consequence of changes in the long-range transport spatial pattern. Henceforth, the comparison of wind speed and direction, geopotencial height and sea level pressure (SLP) against ERA5 data shows a better representation of the dynamical patterns when decreasing spatial resolution.
Disentangling Drought and Nutrient Effects on Soil Carbon Dioxide and Methane Fluxes in a Tropical Forest

Tropical soils are a major contributor to the balance of greenhouse gas (GHG) fluxes in the atmosphere. Models of tropical GHG fluxes predict that both the frequency of drought events and changes in atmospheric deposition of nitrogen (N) will significantly affect dynamics of soil carbon dioxide (CO2) and methane (CH4) production and consumption. In this study, we examined the combined effect of a reduction in precipitation and an increase in nutrient availability on soil CO2 and CH4 fluxes in a primary French Guiana tropical forest. Drought conditions were simulated by intercepting precipitation falling through the forest canopy with tarpaulin roofs. Nutrient availability was manipulated through application of granular N and / or phosphorus (P) fertilizer to the soil. Soil water content (SWC) below the roofs decreased rapidly and stayed at continuously low values until roof removal, which as a consequence roughly doubled the duration of the dry season. After roof removal, SWC slowly increased but remained lower than in the control soils even after 2.5 months of wet-season precipitation. We showed that drought-imposed reduction in SWC decreased the CO2 emissions (i.e CO2 efflux), but strongly increased the CH4 emissions. N, P and N × P (i.e. NP) additions all significantly increased CO2 emission but had no effect on CH4 fluxes. In treatments where both fertilization and drought were applied, the positive effect of N, P and NP fertilization on CO2 efflux was reduced. After roof removal, soil CO2 efflux was more resilient in the control plots than in the fertilized plots while there was only a modest effect of roof removal on soil CH4 fluxes. Our results suggest that a combined increase in drought and nutrient availability in soil can locally increase the emissions of both CO2 and CH4 from tropical soils, for a long term.
JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation

Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from hematopoietic stem cells (HSCs) that differentiate through common lymphoid progenitors (CLPs) to NK lineage-restricted progenitors (NKPs). The orchestrated action of multiple cytokines is crucial for NK cell development and maturation. Many of these cytokines such as IL-2, IL-7, IL-12, IL-15, IL-21, IL-27, and interferons (IFNs) signal via the Janus Kinase / Signal Transducer and Activator of Transcription (JAK/STAT) pathway. We here review the current knowledge about these cytokines and the downstream signaling involved in the development and maturation of conventional NK cells and their close relatives, innate lymphoid cells type 1 (ILC1). We further discuss the role of suppressor of cytokine signaling (SOCS) proteins in NK cells and highlight their potential for therapeutic application.
Assessing mental health as a measure of work potential

Previous research has shown that mental health issues in the work place lead to absenteeism, lost productive time (LPT), and unemployment. This study examined the utility of the Work Potential Profile (WPP) in assessing depression, anxiety, and preoccupation with health as part of a measure of work potential. The main purpose of this study was to establish convergent validity for the WPP by correlating selected WPP profile scores with the MMPI-2 scales of depression (Scale 1), psychasthenia (Scale 7), and hypochondriasis (Scale 1), and to establish divergent validity by correlating the WPP profile scores with the MMPI-2 masculinityfemininity scale (Scale 5). The WPP and MMPI-2 were administered to 202 participants during a psychological evaluation in a private practice, and then selected scales were correlated to determine convergent and divergent validity. It was found that the profile scores of the WPP correlated significantly with their corresponding MMPI-2 scales but did not correlate significantly with the masculinity-femininity scale. In addition step-wise multiple regressions were used to establish which of the selected MMPI-2 scales best predicted selected WPP profile scores. It was found that the combination of MMPI-2 Scale 2 and Scale 7 best predicted the WPP profile score of Stress and Anxiety. Also the same combination of MMPI-2 Scale 2 and Scale 7 best predicted the WPP profile score of Depression/Resentment. Furthermore, the combination of MMPI-2 Scale 7 and Scale 1 best predicted the WPP profile score of Preoccupation with Health. This validates that the WPP helps in better identifying those with decreased absenteeism, LPT, and unemployment because of mental health needs, and to formulate better interventions. Mental Health and Work iv
Active Preconditioning With Blood Flow Restriction or/and Systemic Hypoxic Exposure Does Not Improve Repeated Sprint Cycling Performance

Purpose The aim of this study was to evaluate the effects of active preconditioning techniques using blood flow restriction or/and systemic hypoxic exposure on repeated sprint cycling performance and oxygenation responses. Methods Participants were 17 men; 8 were cycle trained (T: 21 ± 6 h/week) and 9 were untrained but physically active (UT). Each participant completed 4 cycles of 5 min stages of cycling at 1.5 W⋅kg–1 in four conditions [Control; IPC (ischemic preconditioning) with partial blood flow restriction (60% of relative total occlusion pressure); HPC (hypoxic preconditioning) in normobaric systemic hypoxia (FIO2 13.6%); and HIPC (hypoxic and ischemic preconditioning combined)]. Following a 40 min rest period, a repeated sprint exercise (RSE: 8 × 10 s sprints; 20 s of recovery) was performed. Near-infrared spectroscopy parameters [for each sprint, change in deoxyhemoglobin (Δ[HHb]), total hemoglobin (Δ[tHb]), and tissue saturation index (ΔTSI%)] were measured. Results Trained participants achieved higher power outputs (+10–16%) than UT in all conditions, yet RSE performance did not differ between active preconditioning techniques in the two groups. All conditions induced similar sprint decrement scores during RSE in both T and UT (16 ± 2 vs. 23 ± 9% in CON; 17 ± 3 vs. 19 ± 6% in IPC; 18 ± 5 vs. 20 ± 10% in HPC; and 17 ± 3 vs. 21 ± 5% in HIPC, for T and UT, respectively). During the sprints, Δ[HHb] was larger after IPC than both HPC and CON in T (p < 0.001). The Δ[tHb] was greater after HPC than all other conditions in T, whereas IPC, HPC, and HIPC induced higher Δ[tHb] than CON in UT. Conclusion None of the active preconditioning methods had an ergogenic effect on repeated sprint cycling performance, despite some specific hemodynamic responses (e.g., greater oxygen extraction and changes in blood volume), which were emphasized in the trained cyclists.
Statistical caching for near memory management

Modern GPUs often use near memory or high-bandwidth memory, which may be managed as cache when the application data is too large to fit in the near memory. Unlike CPU caches, the near memory cache has a much larger size. A recent approach is statistical caching, which shows near optimal results when managing large memory for file caching. The prior work is ideal and not practical. This paper outlines two extensions. It first formulates a new caching algorithm called least expected use (LEU) replacement and shows, through examples, that the statistical solution automatically integrates two otherwise disparate policies. Then the paper describes a system design to implement LEU. To position the new design for discussion, the paper draws parallels with two familiar ideas, branch prediction and spectral analysis, and considers a set of opportunities and challenges of achieving statistical caching in near memory.
Postnatal Feeding With a Fat Rich Diet Induces Precocious Puberty Independent of Body Weight, Body Fat, and Leptin Levels in Female Mice

Puberty generally occurs when an individual has stored a sufficient amount of energy. Previous reports have shown that postnatal overfeeding, induced by a small litter size or maternal high fat diet (HFD) feeding during gestation and lactation increases body weight (BW), body fat, plasma leptin levels, and induces precocious puberty. The role of BW, body fat, and leptin in postnatal HFD-induced precocious puberty is poorly understood. In this study, we investigated if postnatal HFD feeding induces precocious puberty independent of BW, body fat, and leptin levels. Different litter sizes and different exposure time to HFD were used to produce HFD feeding pups with different BW and body fat. BW, body fat, and plasma hormones levels were checked at different time points to test their relation with HFD-induced precocious puberty. Our results showed that postnatal HFD feeding increases BW, body fat, adipocyte size, and induces precocious puberty. HFD-induced precocious puberty was independent of BW, body fat, and plasma leptin levels. Plasma gonadotrophin, estradiol, testosterone and insulin levels were comparable in most of the groups. Our results collectively suggest that postnatal HFD feeding induces precocious puberty independent of BW, body fat and plasma leptin levels. Our results also suggest that HFD feeding acts as a stimulator for puberty onset but further studies are needed to understand how it induces precocious puberty.
Xiaoyao Pills Prevent Lipopolysaccharide-Induced Depression by Inhibiting Inflammation and Protecting Nerves

Lipopolysaccharides are pro-inflammation mediators that can induce inflammation in the serum, hippocampus, and cortex of animals. And lipopolysaccharide-induced neuroinflammatory state resulted in significant depression-like behaviors, including reduced locomotor activity in the open field test, reduced saccharin preference, added immobility time in tail suspension test and forced swimming test, decreased comb time in the splash test, and increased latency to food in the novelty suppressed feeding test time, and reduced the levels of neurotrophic factors and synaptic proteins, and decreased Nissl bodies. Treatment with Xiaoyao Pills ameliorated the depression-like behavior, decreased the levels of inflammatory indicators, increased those of neurotrophic factors and synaptic proteins, and restored Nissl bodies. Our study suggests that lipopolysaccharides induce inflammation and nerve injury, thereby leading to depression. Xiaoyao Pills could be considered a potential therapeutic candidate for inflammation-induced depression.
Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum

The target for the “rapid” (<24 h) antidepressant effects of S-ketamine is unknown, vitiating programs to rationally develop more effective rapid antidepressants. To describe a drug’s target, one must first understand the compartments entered by the drug, at all levels—the organ, the cell, and the organelle. We have, therefore, developed molecular tools to measure the subcellular, organellar pharmacokinetics of S-ketamine. The tools are genetically encoded intensity-based S-ketamine-sensing fluorescent reporters, iSKetSnFR1 and iSKetSnFR2. In solution, these biosensors respond to S-ketamine with a sensitivity, S-slope = delta(F/F0)/(delta[S-ketamine]) of 0.23 and 1.9/μM, respectively. The iSKetSnFR2 construct allows measurements at <0.3 μM S-ketamine. The iSKetSnFR1 and iSKetSnFR2 biosensors display >100-fold selectivity over other ligands tested, including R-ketamine. We targeted each of the sensors to either the plasma membrane (PM) or the endoplasmic reticulum (ER). Measurements on these biosensors expressed in Neuro2a cells and in human dopaminergic neurons differentiated from induced pluripotent stem cells (iPSCs) show that S-ketamine enters the ER within a few seconds after appearing in the external solution near the PM, then leaves as rapidly after S-ketamine is removed from the extracellular solution. In cells, S-slopes for the ER and PM-targeted sensors differ by <2-fold, indicating that the ER [S-ketamine] is less than 2-fold different from the extracellular [S-ketamine]. Organelles represent potential compartments for the engagement of S-ketamine with its antidepressant target, and potential S-ketamine targets include organellar ion channels, receptors, and transporters.
Hematoprotective Effect of N(G)-Nitro-L-Arginine Methyl Ester and Lycopene on Hematoxicity in Trinitrobenzene Sulfonic Acid–Induced Colitis in Rat -

Abstract Anemia is a neglected manifestation of inflammatory bowel disease (IBD) although it is commonly observed in IBD patients. Attempts to overcome anemia in IBD would help not only general well being of the patients but also minimize disease consequences. In this experimental study, the possible hematoprotective effects of lycopene and NG–nitro-L-arginine methyl ester (L-NAME) on colitis induced by TNBS were analyzed. 112 rats were assigned to 16 groups; control group, intrarectal 120 mg/kg TNBS group, intraperitoneal 40 mg/kg L-NAME group, 1 mg/kg olive oil group, 5 and 10 mg/kg lycopene groups. Each experimental group was divided into 3 subgroups according to duration of treatment. On the very first day of treatment number of erythrocytes decreased in all groups except TNBS treated group whereas leukocyte numbers increased in all groups except TNBS treated group pointing out an inflammation. The number of platelets decreased in all study groups with the exception of TNBS group. On the second day, while erythrocyte and platelet numbers increased in all but not in TNBS group, leukocytes decreased in all the groups. On the third day, erythrocyte and platelet numbers increased in all groups except for the 10 mg/kg lycopene group. While the number of leukocytes decreased in the 10 mg/kg lycopene group, it remained the same in the other groups as those observed on the second day. These results show that lycopene could have effects on hemopoiesis as well as in prevention of anemia in IBD. Keywords: TNBS, colitis, lycopene, hematoprotectivity