Miracle-dz/UniFAR-FTUs huggingface dataset:
On Statistical Inference for the Random Set Generated Cox Process with Set‐marking

Cox point process is a process class for hierarchical modelling of systems of non‐interacting points in ℝd under environmental heterogeneity which is modelled through a random intensity function. In this work a class of Cox processes is suggested where the random intensity is generated by a random closed set. Such heterogeneity appears for example in forestry where silvicultural treatments like harvesting and site‐preparation create geometrical patterns for tree density variation in two different phases. In this paper the second order property, important both in data analysis and in the context of spatial sampling, is derived. The usefulness of the random set generated Cox process is highly increased, if for each point it is observed whether it is included in the random set or not. This additional information is easy and economical to obtain in many cases and is hence of practical value; it leads to marks for the points. The resulting random set marked Cox process is a marked point process where the marks are intensity‐dependent. The problem with set‐marking is that the marks are not a representative sample from the random set. This paper derives the second order property of the random set marked Cox process and suggests a practical estimation method for area fraction and covariance of the random set and for the point densities within and outside the random set. A simulated example and a forestry example are given. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Thoracic Epidural Bupivacaine Attenuates Supraventricular Tachyarrhythmias After Pulmonary Resection

Supraventricular tachyarrhythmias after pulmonary surgery are well described. Some investigators suggest that tachyarrhythmias after thoracic operations may result from the relative sympathotonic status produced by injury to the cardiac parasympathetic nerves. We examined whether postoperative thoracic sympathetic blockade by thoracic epidural bupivacaine might reduce the tachyarrhythmias after pulmonary resection. Fifty patients with lung cancer were randomized to receive epidural bupivacaine (Group B) or epidural morphine (Group M). Patients in Group B were given 6 to 10 mL of 0.25% bupivacaine epidurally, followed by epidural infusion at 3 to 5 mL/h for 3 days, and patients in Group M were given 2 to 3 mg morphine epidurally, followed by morphine infusion at a rate of 0.2 mg/h. Tachyarrhythmias were diagnosed by using the continuous heart rate trend and arrhythmia trend with a central monitoring system. Postoperative analgesia was not statistically different between groups. However, the incidence of postoperative tachyarrhythmias in Group B was significantly less than in Group M (1 of 23 vs 7 of 25, P = 0.0497, Fisher’s exact test). The continuous infusion of thoracic epidural bupivacaine can reduce supraventricular tachyarrhythmias compared with epidural morphine infusion, presumably because of attenuation of the sympathotonic status after pulmonary resection.
Relative afferent pupillary defect in eyes with retinal detachment.

Relative afferent pupillary defects were measured before and after surgery in 38 patients with unilateral rhegmatogenous retinal detachment. All 38 patients were measured preoperatively and the mean (+/- SD) pupillary defect was 1.4 +/- 0.7 log units. The afferent pupillary defect decreased in 36 of the 38 patients after successful scleral buckling operations (postoperative mean = 0.4 +/- 0.3 log units). Twenty patients had defects postoperatively of 0.3 log units or less, and seven of these had no measurable defects at all. A prediction model, using the variables of total number of peripheral quadrants detached and whether the macula was detached, yielded the following prediction equation: Relative afferent pupillary defect (log units) = 0.35 X (total quadrants) + 0.68 X macula detachment. This means that the detachment of each peripheral quadrant of retina caused about 0.35 log units of defect, whereas detachment of the macula caused 0.68 log units. The standard error of this estimate was rather large (+/- .65 log units); therefore, the size of the afferent pupillary defect can only roughly predict the extent of the retinal detachment and vice versa.
Acute pain management: current best evidence provides guide for improved practice.

Effective management of acute pain is a major priority for both patients and healthcare providers. Inadequate control of acute and postoperative pain can lead to adverse outcomes that include pulmonary and thromboembolic complications and additional time in hospital or intensive care, with associated increased costs [1]. It can also have negative effects on mobility and function, emotional well-being, quality of life, and overall recovery [2]. Although significant advances have been made in the understanding, assessment, and management of acute pain, further improvements in clinical practice are required. This can be assisted by the provision of up-to-date evidence-based guidelines. The Australian and New Zealand College of Anaesthetists (ANZCA) and Faculty of Pain Medicine (FPM) have recently published the Second Edition of “Acute Pain Management: Scientific Evidence”[3]. This document is a compilation of current evidence and expert practice relevant to acute pain management across a wide range of patient populations and clinical settings, and therefore a systematic approach with multidisciplinary collaboration was required. A Working Party was convened by ANZCA to appoint contributors and edit submissions. Searches of electronic databases and recent publications were conducted (as outlined in Appendix B of the document) and were greatly aided by systematic reviews that had been published by the Cochrane Collaboration and Oxford Pain Group. Evidence was graded according to current Australian National Health and Medical Research Council (NHMRC) criteria (see Table 1) with assistance from the NHMRC Guidelines Assessment Register. Since the publication of the First Edition, “expert opinion” is no longer graded as evidence. However, as high levels of evidence are not available for all interventions, recommended best practice based on experience and expert opinion was included as “clinical practice points. ” The initial draft document was reviewed by a multidisciplinary consultative committee, made up of members of …
Cooperative architecture of data acquisition for emission reduction in traffic

Increasing fuel prices, short-term inventories with C02 emission growth worldwide have contributed to the development of technology in auto industry. Many advanced technologies in the auto industry have emerged in the last decade, but with little focus on driver behavior to reduce fuel consumption. With the implementation of cooperative intelligent transport system (C-ITS) architecture for data acquisition from the vehicles it is possible to achieve defined energy and environmental requirements in traffic. In this paper the areas of application of C-ITS in terms of support for eco-driving will be defined and presented. Also, the implementation of presented system can have the influence on traffic flow and other traffic parameters, but defines new requirements for other involved subsystems (driver-vehicle-infrastructure).
Graph Navigation for Exploring Very Large Image Collections

We present a new approach to visually browse very large sets of untagged images. In this paper we describe how to generate high quality image descriptors/features using transformed activations of a convolutional neural network. These features are used to model image similarities, which again are used to build a hierarchical image graph. We show how such an image graph can be constructed efficiently. After investigating several browsing and visualization concepts, we found best user experience and ease of usage is achieved by projecting sub-graphs onto a regular 2D-image map. This allows users to explore the image graph similar to navigation services.
Psychological factors of propensity for alcoholism (social anxiety, hostility, Machiavellianism) in depressive patients

Based on the analysis of psychosocial models of alcoholism and depression the general and specific factors of occurrence and course of illness are identified in the present study. The authors put forward hypotheses regarding the mechanisms of activation of psychological addiction to alcohol as an ineffective coping strategy. The necessity of empirical research needed to refine the techniques and targets of patient care within the psychiatric and psychological care is justified. The results of the pilot study show that depressed patients who are subject to alcohol dependence feature marked distress in interpersonal relations, coupled with hostility and aim at gaining profit and pleasure by manipulating other people. These patients are hostile to others, while in interpersonal relationships personal safety is important to them, so they may be more likely to resort to manipulation. In their attitudes with respect to health the communication of these patients is characterized by hedonistic tendencies and histrionic traits in interpersonal contacts.
Joint audio-video processing for biometric speaker identification

In this paper we present a bimodal audio-visual speaker identification system. The objective is to improve the recognition performance over conventional unimodal schemes. The proposed system exploits not only the temporal and spatial correlations existing in speech and video signals of a speaker, but also the cross-correlation between these two modalities. Lip images extracted for each video frame are transformed onto an eigenspace. The obtained eigenlip coefficients are interpolated to match the rate of the speech signal and fused with mel frequency cepstral coefficients (MFCC) of the corresponding speech signal. The resulting joint feature vectors are used to train and test a hidden Markov model (HMM) based identification system. Experimental results are also included for demonstration of the system performance.
IRISA at TrecVid2016: Crossmodality, Multimodality and Monomodality for Video Hyperlinking

This paper presents the runs that were submitted to the TRECVid Challenge 2016 for the Video Hyperlinking task. The task aims at proposing a set of video segments, called targets, to complement a query video segment defined as anchor. The 2016 edition of the task encouraged participants to use multiple modalities. In this context, we chose to submit four runs in order to assess the pros and cons of using two modalities instead of a single one and how crossmodality differs from multimodality in terms of relevance. The crossmodal run performed best and obtained the best precision at rank 5 among participants.
Investigation of sleep stages identification with time-scale based parameters

In this study, the time-scale based analysis of EEG signals is shown for recognition of sleep stages. The EEG signals from healthy subjects are analyzed by Scalogram method in the time-scale domain. We observed that statistical parameters, the average gray level and measure of uniformity extracted from the energy distribution images, are found to be effective on the recognition of sleep stages.
Effect of serum albumin on serum sodium: necessity to consider the Donnan effect.

Sir, In a recent issue of QJM , Kengne et al. defined the association between mild asymptomatic hyponatremia and bone fracture.1 However, the defined association might reflect the effect of hypoalbuminemia on bone fracture and incidental fall, because hyponatremia frequently associates with hypoalbuminemia and the association is probably causal.2,3 Depletion of effective circulatory volume in hypoalbuminemia triggers secretion of antidiuretic hormone, which can induce hyponatremia.3,4 Despite this causal association, not only the study by Kengne et al. but also several studies dealing with serum sodium did not …
Experience of Using the Recombinant Human Superoxide Dismutase Drug in Neurological and Ophthalmological Practice

Recsod? has been used for treating epilepsy and ophthalmological disease. Oxidative stress has been demonstrated to be a pathogenic chain of these diseases. Parameters of pro- and antioxidant systems were studied in all the patients treated. Recsod? drug was shown to produce positive effect in all the patients. Improvement of patients’ clinical condition correlated with an increase in antioxidant activities. Antioxidants, in particular, the recombinant human SOD drug, proved to be effective in treatment of some neurological and ophthalmological diseases.
The metabolism of muzigadial by microorganisms.

1. A total of 114 microorganisms were evaluated for their ability to metabolize the antifungal drimane sesquiterpene, muzigadial. 2. Cryptococcus neoformans was found to convert muzigadial to one major metabolite, identified as a hemiacetal. 3. Streptomyces platensis produced three metabolites: the hemiacetal, its corresponding lactone, and the epoxide of the hemiacetal. 4. Streptomyces spectabilis produced the hemiacetal as well as the epoxy hemiacetal. 5. The proposed structures of all of the metabolites were based on comparisons of the spectroscopic data (1H- and 13C-n.m.r. spectra and mass spectra) between the metabolites and the parent compound. 6. Antimicrobial evaluation of the microbial metabolites indicate that metabolism decreases antifungal activity.
Organization of pERK‐immunoreactive cells in trigeminal spinal nucleus caudalis and upper cervical cord following capsaicin injection into oral and craniofacial regions in rats

To define the somatotopic arrangement of neurons in the trigeminal spinal subnucleus caudalis and upper cervical cord activated by acute noxious stimulation of various orofacial sites, pERK expression was analyzed in these neurons. After capsaicin injection into the tongue, lower gum, upper and lower lips, or mental region, pERK‐like immunoreactive (pERK‐LI) cells were distributed mainly in the dorsal half of the trigeminal spinal nucleus interporalis (Vi) and caudalis (Vc) transition zone (Vi/Vc zone), middle Vc, and Vc and upper cervical cord transition zone (Vc/C2 zone). pERK‐LI cells were distributed throughout the dorsal to ventral portion of the Vi/Vc zone, middle Vc, and Vc/C2 zone following capsaicin injection into the anterior hard palate, upper gum, buccal mucosa, or vibrissal pad and in the ventral portion of the Vi/Vc zone, middle Vc, and Vc/C2 zone following snout, ophthalmic, or ocular injection of capsaicin. The rostrocaudal distribution area of pERK‐LI cells was more extensive from the Vi/Vc zone to the Vc/C2 zone after intraoral injection than that after facial injection, and the rostrocaudal distribution of pERK‐LI cells from the Vi/Vc zone to the Vc/C2 zone had a somatotopic arrangement, with the snout being represented most rostrally and ophthalmic, ocular, or mental regions represented most caudally. These findings suggest that the pERK‐LI cells expressed from the Vi/Vc zone to the Vc/C2 zone following injection of capsaicin in facial and intraoral structures may be differentially involved in pain perception in facial and intraoral sites. J. Comp. Neurol. 507:1428–1440, 2008. © 2008 Wiley‐Liss, Inc.
Synthesis of monoesters of pyrroloquinoline quinone and imidazopyrroloquinoline, and radical scavenging activities using electron spin resonance in vitro and pharmacological activity in vivo.

Monoesters with the ester groups at C-2 of pyrroloquinoline quinone (PQQ) and C-9 of imidazopyrroloquinoline (IPQ) were synthesized, and radical scavenging activities of coenzyme PQQ, IPQ compounds synthesized from PQQ and various amino acids, and monoesters of PQQ and IPQ were studied in vitro and in vivo. PQQ and PQQ monoesters had strong radical scavenging activity using ESR in in vitro experiments. The IC50 value for superoxide (O2-) was from 1 to 6 x 10(-8) M and that for the hydroxy radical (.OH) was from 4 to 6 x 10(-5) M. IPQ compounds and IPQ monoesters also showed radical scavenging activity. These compounds prevented injury during in vivo experiments, such as hydrocortisone-induced cataracts, endotoxin shock and CCl4-induced liver injury (isolated hepatocytes and rats). Especially, the monoesters of PQQ and IPQ prevented liver injury in rats equally by oral or intraperitoneal administration. These results suggest that PQQ functions as a radical scavenging factor in addition to being a cofactor of quinoprotein enzymes, and monoesters with the ester groups at C-2 of PQQ and C-9 of IPQ are developed as treatment or preventive medicine for disease caused by radical compounds on the basis of strong radical scavenging activities, absorbability into cells, toxicity, safety and chemical stability.
Symposium Highlights and Synopses of the Scientific Program

Summary As the bar to actively participate in one’s own health is consistently lowered through technology, patients are helping to evolve traditional workflows to make data more accessible at the point of care. This growing trend of patient engagement and personalized medicine was the focus of the 2013 Mid-Atlantic Healthcare Informatics Symposium in Philadelphia, PA on April 26, 2013. The conference, presented annually by the Center for Biomedical Informatics (CBMi) at The Children’s Hospital of Philadelphia, featured plenary sessions, panel discussions, and paper presentations on a range of topics, including patient engagement and personalized medicine; using data and analytics to optimize patient care; nursing informatics; and the future of biomedical informatics. Citation: Vito D, Diltz M, Porter M, White P, Luberti A. Symposium highlights and synopses of the scientific program: The sixth annual mid-atlantic healthcare informatics symposium. Appl Clin Inf 2014; 5: 85–91 http://dx.doi. org/10.4338/ACI-2013-10-IE-0082
Mexiletine: A New Type I Antiarrhythmic Agent

Mexiletine is a type I antiarrhythmic drug that is structurally similar to lidocaine. Mexiletine has considerable potential for causing neurologic, cardiac, or gastrointestinal side effects. However, mexiletine does not undergo clinically significant first-pass metabolism and, thus, has good oral bioavailability. Mexiletine has a large and variable volume of distribution and an elimination half-life ranging from 6 to 12 hours. Mexiletine disposition is probably altered in patients with heart failure, liver disease, and severe renal dysfunction. Efficacy and toxicity are not well correlated with mexiletine serum concentrations. Mexiletine is as effective as traditional antiarrhythmics in the treatment of premature ventricular contractions. However, in patients with drug-refractory inducible ventricular tachycardia, mexiletine is usually ineffective when used alone. When mexiletine is combined with other antiarrhythmic agents, a significantly higher percentage of patients with this difficult arrhythmia have a good response. Mexiletine is a potentially important addition to the existing antiarrhythmic drugs currently available, but its place in the clinical setting and in therapeutic drug monitoring is not well defined at this time.
Physical therapy for correcting postural and coordination deficits in patients with mild-to-moderate traumatic brain injury

Abstract The purpose of this study was to test the effects of a conventional exercise program designed for correcting postural and coordination abnormalities in patients with mild-to-moderate traumatic brain injury (TBI). Using principles of motor learning applied to functional exercise training, exercises were performed while lying, sitting, standing and walking, with the goal of improving intra- and inter-limb coordination in the upper and lower extremities, postural stability and gait pattern. Twenty-two participants with TBI-related deficits received therapy in a supervised outpatient clinic. Therapy included 20 sessions, each approximately 55 to 60 min in duration, scheduled four to five times a week over four consecutive weeks. Each participant was evaluated with a battery of clinical tests at baseline and immediately after therapy. Upon completion of the therapy, participants improved static and dynamic postural stability and gait, evaluated with the Berg Balance Scale (from 45.2 ± 5.9 to 49.2 ± 4.2 points) and the Functional Gait Assessment (from 22.8 ± 4.1 to 26.9 ± 3.4 points). They also reduced truncal, upper and lower extremity ataxia, evaluated with the Ataxia Scale (from 7.3 ± 4.5 to 5.9 ± 4.2 points). Results will be used to refine the current version of the exercise therapy, which focused on whole body coordination and balance, and to design a large-scale clinical trial establishing effectiveness of this intervention and for comparison with other forms of therapy.
Challenging GRB models through the broadband dataset of GRB060908

Context: Multiwavelength observations of gamma-ray burst prompt and afterglow emission are a key tool to disentangle the various possible emission processes and scenarios proposed to interpret the complex gamma-ray burst phenomenology. Aims: We collected a large dataset on GRB060908 in order to carry out a comprehensive analysis of the prompt emission as well as the early and late afterglow. Methods: Data from Swift-BAT, -XRT and -UVOT together with data from a number of different ground-based optical/NIR and millimeter telescopes allowed us to follow the afterglow evolution from about a minute from the high-energy event down to the host galaxy limit. We discuss the physical parameters required to model these emissions. Results: The prompt emission of GRB060908 was characterized by two main periods of activity, spaced by a few seconds of low intensity, with a tight correlation between activity and spectral hardness. Observations of the afterglow began less than one minute after the high-energy event, when it was already in a decaying phase, and it was characterized by a rather flat optical/NIR spectrum which can be interpreted as due to a hard energy-distribution of the emitting electrons. On the other hand, the X-ray spectrum of the afterglow could be fit by a rather soft electron distribution. Conclusions: GRB060908 is a good example of a gamma-ray burst with a rich multi-wavelength set of observations. The availability of this dataset, built thanks to the joint efforts of many different teams, allowed us to carry out stringent tests for various interpretative scenarios showing that a satisfactorily modeling of this event is challenging. In the future, similar efforts will enable us to obtain optical/NIR coverage comparable in quality and quantity to the X-ray data for more events, therefore opening new avenues to progress gamma-ray burst research.