Miracle-dz/UniFAR-FTUs huggingface dataset:
How to Exploit Scene Constraints to Improve Object Categorization Algorithms for Industrial Applications?

State-of-the-art object categorization algorithms are designed to be heavily robust against scene variations like illumination changes, occlusions, scale changes, orientation and location differences, background clutter and object intra-class variability. However, in industrial machine vision applications where objects with variable appearance have to be detected, many of these variations are in fact constant and can be seen as constraints on the scene, which in turn can reduce the enormous search space for object instances. In this position paper we explore the possibility to fixate certain of these variations according to the application specific scene constraints and investigate the influence of these adaptations on three main aspects of object categorization algorithms: the amount of training data needed, the speed of the detection and the amount of false detections. Moreover, we propose steps to simplify the training process under such scene constraints.
A Proposal of High-Flexibility Short-Range Cognitive Radio System

A new cognitive radio (CR) system for short-range high-capacity wireless communication is proposed. A transceiver selects 1 GHz-bandwidth main bands from the frequency range of 3-12 GHz, and places single-carrier modulated sub-bands at unused frequencies. The frequencies of main bands and sub-bands are flexibly changed according to the occupancy condition. A transceiver performs two kinds of carrier sensing. Longer duration carrier sensing is performed to recognize frequency occupancy conditions and determine the frequencies of main bands and sub-bands. Shorter duration carrier sensing is performed, which checks the sub-band frequencies just before transmitting to detect whether any primary system signal is included or not. The transceiver estimates the type of detected interference and transmission will be stopped if it is from a primary user. This system realizes the reduction of interference to other systems, and improves the throughput of the CR system itself. Furthermore, some of the key technologies to realize the proposed system are introduced.
Biophysical assays to probe the mechanical properties of the interphase cell nucleus: substrate strain application and microneedle manipulation.

In most eukaryotic cells, the nucleus is the largest organelle and is typically 2 to 10 times stiffer than the surrounding cytoskeleton; consequently, the physical properties of the nucleus contribute significantly to the overall biomechanical behavior of cells under physiological and pathological conditions. For example, in migrating neutrophils and invading cancer cells, nuclear stiffness can pose a major obstacle during extravasation or passage through narrow spaces within tissues. (1) On the other hand, the nucleus of cells in mechanically active tissue such as muscle requires sufficient structural support to withstand repetitive mechanical stress. Importantly, the nucleus is tightly integrated into the cellular architecture; it is physically connected to the surrounding cytoskeleton, which is a critical requirement for the intracellular movement and positioning of the nucleus, for example, in polarized cells, synaptic nuclei at neuromuscular junctions, or in migrating cells. (2) Not surprisingly, mutations in nuclear envelope proteins such as lamins and nesprins, which play a critical role in determining nuclear stiffness and nucleo-cytoskeletal coupling, have been shown recently to result in a number of human diseases, including Emery-Dreifuss muscular dystrophy, limb-girdle muscular dystrophy, and dilated cardiomyopathy. (3) To investigate the biophysical function of diverse nuclear envelope proteins and the effect of specific mutations, we have developed experimental methods to study the physical properties of the nucleus in single, living cells subjected to global or localized mechanical perturbation. Measuring induced nuclear deformations in response to precisely applied substrate strain application yields important information on the deformability of the nucleus and allows quantitative comparison between different mutations or cell lines deficient for specific nuclear envelope proteins. Localized cytoskeletal strain application with a microneedle is used to complement this assay and can yield additional information on intracellular force transmission between the nucleus and the cytoskeleton. Studying nuclear mechanics in intact living cells preserves the normal intracellular architecture and avoids potential artifacts that can arise when working with isolated nuclei. Furthermore, substrate strain application presents a good model for the physiological stress experienced by cells in muscle or other tissues (e.g., vascular smooth muscle cells exposed to vessel strain). Lastly, while these tools have been developed primarily to study nuclear mechanics, they can also be applied to investigate the function of cytoskeletal proteins and mechanotransduction signaling.
Current knowledge of influenza vaccine.

When potent vaccines of appropriate antigenic composition are used properly, an important degree of protection against epidemic influenza is assured. Knowledge accumulated concerning the toll exacted by epidemics of influenza recommends extension of coverage of the population by vaccination. That recommendation is especially pertinent this year, since it seems likely that a widespread epidemic of Asian influenza will occur in the United States during 1962-1963. Specific indications concerning dosage, route, schedules, and types of patients requiring first consideration are given.
11 In Vitro and In Vivo Transactivation of HIV-1 by Human Herpesvirus 6

1.1 Latency and reactivation of HIV-1 Since the discovery of human immunodeficiency virus type 1 (HIV-1), there has been a great deal of interest in identifying cofactors that might accelerate the stages of development associated with acquired immunodeficiency syndrome (AIDS). Many environmental agents, namely inherent factors such as ethnicity and geographical location, were first implicated as risk factors in the study of HIV infection. However, speculation that infectious diseases may act as cofactors in HIV infection began to be studied soon thereafter. These speculations led to one of the early opinions that HIV plays a correlary role in AIDS, but not a causative role (Duesberg, 1989). AIDS patients have a history of both circumstantial serological and microbial evidence of increased exposure to a number of common and opportunistic infectious agents. It is difficult to ascertain, however, whether these various coinfections contribute anything to the progressive decline of the immune system (Pedersen et al., 1990). In vivo, infection with HIV-1 is followed by a long disease-free period, during which a low number of CD4+ mononuclear leukocytes (CCR5 coreceptor positive monocytes and CXCR4 coreceptor positive lymphocytes) containing transcriptionally silent integrated provirus can be found. HIV-1 replication can be demonstrated in only a small population of T cells without inducing clinical manifestations. This state of latency is partly due to low transcriptional activity of the integrated provirus in resting cells. Activation of CD4+ cells by antigens, mitogens (Tobiume et al., 1998) or superinfection by other viruses interacting with HIV-1 via viral and/or cellular transacting factors may terminate HIV-1 latency, leading to a productive HIV-1 infection. Transactivation of the HIV-1 long terminal repeat (LTR) in turn will induce gene expression, including the synthesis of the HIV-1 transactivator protein (TAT) (Arya et al., 1985). TAT will then independently amplify HIV-1 gene expression, ultimately leading to a high level of virus replication and death of infected cells. Onset and progression of AIDS correlates with augmented production of infectious virions parallel to a
Psychological Distress and Milk Volume in Lactating Mothers

The purpose of this article is twofold: (a) to compare psychological distress as measured via self-reported perceived stress, sleep, and fatigue levels in lactating mothers of a term infant and mothers of a preterm infant and(b) to determine whether the addition of psychological distress to a previous model predicts milk volume at Postpartum Week 6 by gestation group. The convenience sample of 95 mothers of a preterm infant (31 weeks) and 98 mothers of a term infant completed the Perceived Stress Visual Analogue Scale, Richards-Campbell Sleep Questionnaire, and the Fatigue Visual Analog Scale. Stress, sleep difficulty, and fatigue levels decreased during the 6-week study period for mothers of a term but not for mothers of a preterm infant. Perceived stress, sleep difficulty, and fatigue during the first 6 weeks postpartum were not related to milk volume; thus, the mother’s perceived psychological distress had no apparent effect on lactation.
Recommender Systems and Social Networks: an application in Cultural Heritage

In the last decade Recommender Systems have become useful tools helping users to ﬁnd “what they need” from considerable amount of data. One of the more obvious applications of such systems in the Cultural Heritage domain is to assist users when visiting cultural environments (such as museums, archaeological sites, old town centers and so on), providing a multimedia guide that is able to dynamically suggest relevant information available in multiple web repositories (e.g. multimedia sharing systems and on-line social networks). In this paper, we propose a novel recommendation approach that combines several aspects of users - i.e. their preferences (usually in the shape of items’ metadata) and interactions within a social community modeled using hypergraphs - together with items’ multimedia features and context information within a general framework that can support di ↵ erent applications (touristic guiding services for museums, visiting paths recommendation for old town centers and archeological sites, etc.). Preliminary experiments on user satisfaction show how our approach provides very promising and interesting results.
Training-based head pose estimation under monocular vision

Although many 3D head pose estimation methods based on monocular vision can achieve an accuracy of 5°, how to reduce the number of required training samples and how to not to use any hardware parameters as input features are still among the biggest challenges in the field of head pose estimation. To aim at these challenges, the authors propose an accurate head pose estimation method which can act as an extension to facial key point detection systems. The basic idea is to use the normalised distance between key points as input features, and to use l1-minimisation to select a set of sparse training samples which can reflect the mapping relationship between the feature vector space and the head pose space. The linear combination of the head poses corresponding to these samples represents the head pose of the test sample. The experiment results show that the authors’ method can achieve an accuracy of 2.6° without any extra hardware parameters or information of the subject. In addition, in the case of large head movement and varying illumination, the authors’ method is still able to estimate the head pose.
Protection effect of cosmetics on human skin under simulated rigorous environment

Background/purpose: The efficacy of cosmetics on human skin measured under normal mild laboratory environment might be discounted by exterior environment factors such as wind, UV exposure, etc. Few studies have focused on the ‘genuine’ efficacy of cosmetics on human skin during exposure to external rigorous environment. The aim of this study was to develop a model for the evaluation of the efficacy of cosmetics on human skin under simulated rigorous environment.
Generalizing Virtual Network Topologies in OpenFlow-Based Networks

Network Virtualization (NV) is one of the most promising technique to enable innovation in today's network. A recent approach toward NV has been proposed through FlowVisor, whose aim is to leverage on the specific features of an OpenFlow-controlled network to share the same hardware forwarding plane among multiple logical networks. However, FlowVisor lacks some features to enable a full implementation of a NV architecture: the virtual topologies that can be established are restricted to subsets of the physical topology and it has no way for two slices to share flowspace and simultaneously prevent them from interfering with each other's traffic. In this work, an innovative system called ADVisor (ADvanced FlowVisor) which enhances FlowVisor while overcoming its major constraints is presented and a set of experimental results discussed to demonstrate its capability to provide an effective support toward a Network Virtualization architecture.
DNA relaxation by human topoisomerase I occurs in the closed clamp conformation of the protein

In cocrystal structures of human topoisomerase I and DNA, the enzyme is tightly clamped around the DNA helix. After cleavage and covalent attachment of the enzyme to the 3′ end at the nick, DNA relaxation requires rotation of the DNA helix downstream of the cleavage site. Models based on the cocrystal structure reveal that there is insufficient space in the protein for such DNA rotation without some deformation of the cap and linker regions of the enzyme. Alternatively, it is conceivable that the protein clamp opens to facilitate the rotation process. To distinguish between these two possibilities, we engineered two cysteines into the opposing loops of the “lips” region of the enzyme, which allowed us to lock the protein via a disulfide crosslink in the closed conformation around the DNA. Importantly, the rate of DNA relaxation when the enzyme was locked on the DNA was comparable to that observed in the absence of the disulfide crosslink. These results indicate that DNA relaxation likely proceeds without extensive opening of the enzyme clamp.
ISUOG Practice Guidelines: role of ultrasound in twin pregnancy

The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) is a scientific organization that encourages sound clinical practice, and high quality teaching and research related to diagnostic imaging in women's healthcare. The ISUOG Clinical Standards Com mittee (CSC) has a remit to develop Practice Gui delines and Consensus Statements as educational recommendations that provide healthcare practit ioners with a consensus based approach, from experts, for diagnostic imaging. They are intended to reflect what is considered by ISUOG to be the best practice at the time at which they are issued. Although ISUOG has made every effort to ensure that Guidelines are accurate when issued, neither the Society nor any of its employees or members accepts any liability for the consequences of any inaccurate or misleading data, opinions or state ments issued by the CSC. The ISUOG CSC docu ments are not intended to establish a legal stan dard of care because interpretation of the eviden ce that underpins the Guidelines may be influen ced by individual circumstances, local protocol and available resources. Approved Guidelines can be distributed freely with the permission of ISUOG (info@isuog.org).
Targeting ASK1 in ER stress-related neurodegenerative diseases

The accumulation of malfolded proteins in the endoplasmic reticulum (ER) induces ER stress, leading to the disturbance of ER function. To restore ER function and ER homeostasis, cells possess a highly specific ER quality control system termed the unfolded protein response (UPR), which increases the capacity of protein folding and reduces the amount of malfolded proteins. In case of prolonged ER stress or malfunction of the UPR, apoptosis signaling is activated. ER stress-induced apoptosis has recently been implicated in the pathogenesis of various conformational diseases. Apoptosis signal-regulating kinase 1 (ASK1), a member of the MAPK kinase kinase (MAP3K) family, is activated by ER stress and mediates apoptosis. Recent studies have shown that the ASK1 pathway is involved in ER stress-induced neuronal cell death and contributes to the pathogenesis of neurodegenerative diseases. In this review, we summarize the molecular mechanisms of the UPR and ER stress-induced apoptosis and the possible roles of ASK1 activation in neurodegenerative diseases.
Proposta de indicadores de evolução de empresas incubadas: gestão baseada na metodologia CERNE

Este relato tecnico retrata a intervencao realizada junto ao Centro de Incubacao Tecnologica da FUNDETEC, cujo objetivo foi desenvolver uma proposta de indicadores de desempenho que identifiquem a evolucao das empresas incubadas. Esses indicadores estao vinculados ao processo de monitoramento do desenvolvimento dos empreendimentos, que corresponde a um dos processos-chave exigidos para a implantacao do Metodo CERNE. Em termos metodologicos, a pesquisa caracteriza-se como um estudo de caso qualitativo. Os dados foram coletados por meio de documentos do CERNE, da FUNDETEC e do Centro Incubador. O resultado da intervencao foi dez indicadores de desempenho, distribuidos igualmente entre os eixos do CERNE. Os indicadores sao qualitativos e quantitativos, e tem como caracteristica comum, a viabilidade de aplicacao. Como contribuicoes a incubadora, destaca-se tanto o cumprimento de um processo-chave do CERNE, como tambem, o aprimoramento dos indicadores de desempenho do monitoramento, que e o processo decisivo na graduacao dos empreendimentos.
Future Network: End-to-End Slicing and Hop-On (a Slice)

The concept of network slice, i.e.,a service customized virtual network (VN) is attracting more and more attentions in the telecommunication industry. A slice is a set of network resources which fits the service attributes and requirements of customer services. The network resources consist of cloud resources and communication link resources. A slice can serve one or more customer services which share the similar service attributes and requirements. To define, create and manage a slice (VN) is one aspect of future networks. Another aspect is the slice operation, i.e., the provisioning of services to customers using created slices. In this paper, the focus is put on the configuration of slices and the operation of slices. In this paper, the detailed description of slice (VN) configuration is provided. A new concept of hop-on (a slice) is described. Given a well defined and configured end-to-end slice (VN), the realtime data traffic delivery over a slice is governed by network operation control entities, which are also pre-configured. Therefore, the procedure of customer traffic delivery over a slice is just like a traveler hopping on tourist bus and then the traffic control officers at key intersections directing the traveler to go through pre-designed routes until the destination is reached.
Évaluation des paramètres de locomotion dans une cohorte de patients atteints de polyarthrite rhumatoïde contrôlée sous biothérapie intraveineuse

Introduction : la polyarthrite rhumatoide (PR) est le plus frequent des rhumatismes inflammatoires. Au cours de la derniere decennie, des traitements efficaces cibles ont abouti au controle du processus inflammatoire systemique. La severite de la maladie a significativement diminue. L’objectif principal de l’etude est d’evaluer les capacites de locomotion de patients dont la maladie est en remission ou a faible activite. Materiel et methode : etude monocentrique transversale. Etaient inclus les patients majeurs traites par biotherapie dont le DAS28VS<3,2, le score HAQ<=1 et qui n’etaient pas porteurs d’une prothese des membres inferieurs. Six tests de locomotion ont ete effectues : le 5-levers de chaises, le Timed-Up-and-Go, la vitesse de marche, la force de prehension et l’appui unipodal yeux ouverts et fermes. S’y ajoutait un test de 6-minutes de marche. Etait egalement renseigne le score de Dijon. Resultats: 60 patients ont ete inclus. L’âge median etait de 63 ans (56-68), le DAS28VS median de 2 (1,4-2,5). 33% des patients etaient traites par corticotherapie, 61% par Methotrexate®. Au total, 98% des patients avaient au moins un test locomoteur altere et 68% etaient decrits comme severes avec au moins 4 tests pathologiques. Il existait une correlation negative entre le score de Dijon et le nombre de tests pathologiques (R=-0,40 ; p=0,002). Conclusion : l'ensemble des patients presentait une capacite de locomotion perturbee malgre un controle strict de l’inflammation. Les scores cliniques actuels utilises par les rhumatologues ne semblent pas pouvoir refleter la persistance des alterations fonctionnelles.
Boucle Vélocité / Pression Aortique (PU Loop) pour l’évaluation continue de la post-charge ventriculaire des patients sous anesthésie générale

Durant l’anesthesie generale, des modifications perturbent l’integrite cardiovasculaire des patients. Bien que les vasopresseurs puissent etre utilises pour corriger les episodes d’hypotension arterielle, en elevant la post-charge ventriculaire, aucun moyen de monitorage de leurs effets, potentiellement deleteres, n’est disponible en pratique courante. Cette etude avait pour objectif de decrire GALA (Global AfterLoad Angle), parametre derive de la boucle Velocite-Pression dans l’Aorte (PU loop), durant une analyse comparative des alterations constitutionnelles et pharmacologiques de la post-charge ventriculaire. Vingt patients ont ete inclus et separes selon le nombre de facteur de risque cardiovasculaire. Bien que la pression arterielle moyenne (MAP) fut equivalente, la post-charge ventriculaire etait plus elevee dans le groupe a haut risque. GALA etait egalement plus important (68±6° vs 41±15° ; p<0,001). Une association significative a ete demontree entre GALA et chacun des marqueurs de post-charge ventriculaire. Lors de l’administration de vasopresseurs, nous avons observe une augmentation de MAP et une baisse de debit cardiaque, ainsi qu’une augmentation de la post-charge ventriculaire (p<0,001). GALA etait significativement plus eleve apres vasopresseurs (p < 0,001). Un effet differentiel des vasopresseurs a ete mis en evidence par les marqueurs de post-charge ventriculaires et par GALA. Ainsi GALA pourrait representer un marqueur fiable de la post-charge ventriculaire des patients sous anesthesie generale et etre utilise comme moyen de monitorage continu de l’effet des vasopresseurs au bloc operatoire, dans le but d’ameliorer la securite des patients.
Development and Optimization of Dispersible Tablet of Bacopa monnieri with Improved Functionality for Memory Enhancement

Introduction: The Bacopa monnieri is traditional Ayurvedic medicine, and reported for memory-enhancing effects. The Bacoside is poorly soluble, bitter in taste and responsible for the memory enhancement action. Memory enhancer is commonly prescribed for children or elder people. Objective: Poor solubility, patient compliance and bitterness were a major driving force to develop taste masked β-cyclodextrin complex and dispersible tablets. Materials and Methods: The inclusion complex of Bacopa monnieri and β-cyclodextrin was prepared in different molar ratios of Bacopa monnieri by Co-precipitation method. Phase solubility study was conducted to evaluate the effect of β-cyclodextrin on aqueous solubility of Bacoside A. The characterization was determined by Fourier transformation infrared spectroscopy (FTIR),Differential scanning calorimetry (DSC) and X-ray diffraction study (XRD). Crospovidone and croscarmallose sodium were used as super disintigrant.The 32 full factorial design was adopted to investigate the influence of two superdisintegrants on the wetting time and disntegration time of the tablets. Conclusion: The result revels that molar ratio (1:4) of inclusion complex enhance 3-fold solubility. Full factorial design was successfully employed for the optimization of dispersible tablet of B. monnieri . The short-term accelerated stability study confirmed that high stability of B. monnieri in inclusion complex.