Miracle-dz/UniFAR-FTUs huggingface dataset:
March 15 , 2016 by blocking vascular and adrenal

1115 Abstract—Heart failure affects ≈5.7 million people in the United States alone. Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, β-blockers, and aldosterone antagonists have improved mortality in patients with heart failure and reduced ejection fraction, but mortality remains high. In July 2015, the US Food and Drug Administration approved the first of a new class of drugs for the treatment of heart failure: Valsartan/sacubitril (formerly known as LCZ696 and currently marketed by Novartis as Entresto) combines the angiotensin receptor blocker valsartan and the neprilysin inhibitor prodrug sacubitril in a 1:1 ratio in a sodium supramolecular complex. Sacubitril is converted by esterases to LBQ657, which inhibits neprilysin, the enzyme responsible for the degradation of the natriuretic peptides and many other vasoactive peptides. Thus, this combined angiotensin receptor antagonist and neprilysin inhibitor addresses 2 of the pathophysiological mechanisms of heart failure: activation of the renin-angiotensin-aldosterone system and decreased sensitivity to natriuretic peptides. In the Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial, valsartan/sacubitril significantly reduced mortality and hospitalization for heart failure, as well as blood pressure, compared with enalapril in patients with heart failure, reduced ejection fraction, and an elevated circulating level of brain natriuretic peptide or N-terminal pro-brain natriuretic peptide. Ongoing clinical trials are evaluating the role of valsartan/sacubitril in the treatment of heart failure with preserved ejection fraction and hypertension. We review here the mechanisms of action of valsartan/sacubitril, the pharmacological properties of the drug, and its efficacy and safety in the treatment of heart failure and hypertension. (Circulation. 2016;133:1115-1124. DOI: 10.1161/CIRCULATIONAHA.115.018622.)
Survival in a Mouse Model of Dilated Cardiomyopathy Atrial Natriuretic Peptide Affects Cardiac Remodeling

Dong Wang, Inna P. Gladysheva, Tai-Hwang M. Fan, Ryan Sullivan, Aiilyan K. Houng and Survival in a Mouse Model of Dilated Cardiomyopathy Atrial Natriuretic Peptide Affects Cardiac Remodeling, Function, Heart Failure, and Print ISSN: 0194-911X. Online ISSN: 1524-4563 Copyright © 2013 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Hypertension published online December 30, 2013; Hypertension. http://hyper.ahajournals. org/content/early/2013/12/30/HYPERTENSIONAHA.113. 02164 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://hyper.ahajournals. org/content/suppl/2013/12/30/HYPERTENSIONAHA.113. 02164.DC1. html Data Supplement (unedited) at:
Clinical Investigation : Central Nervous System Tumor Valproic AcidUseDuringRadiation Therapy for Glioblastoma Associated With Improved Survival

Valproic acid (VA) is an antiepileptic drug and histone deacetylase (HDAC) inhibitor taken by patients with glioblastoma to manage seizures; preclinical studies suggest that it can modulate the biologic effects of radiation therapy (RT). We investigated whether VA use during RT for glioblastoma was associated with overall survival by retrospective multivariable analysis in a large cohort. The results suggest that HDAC inhibitors, like VA, may improve the results of RT and should be subjected to clinical trials.
Generating Non-Linear Narratives by Vinay Chilukuri

Stories play a crucial role in our day-to-day lives. Apart from the entertainment sector, they are also being utilized in different areas of games, education and training. The ability to generate rich stories similar to human authored ones is of significance in story generation research. Along with the content of the story the manner in which it is presented is an important factor in effective storytelling. Though a lot of development happened in automatic story generation, most of it ignored the way in which the story could be presented. This thesis deals with a presentation aspect of the story, the order in which the events could be narrated, in order to make it more engaging than that of the chronological versions generated by many story generation systems. We hypothesize that cognitive engagement is manifested when a narrative is deviated from its chronological order without affecting the ease of comprehension. Narratives with events presented in out of chronology are termed non-linear. From a computational perspective, given n events of a story, the total orderings possible are n! Generating an order in random would affect the comprehension of the material. We have studied how the comprehension of the viewers was affected upon changing the presentation order of the events, by employing a commercial feature film. Using these experimental results along with previous theory from narrative comprehension, we arrive at an algorithm that generates different presentation orders of a story by assessing the amount of processing load required for processing an order of events. Using the principles of the event-indexing model, a cognitive model of narrative comprehension, a function was devised that calculates the processing load, by taking input, the desired amount of non-linearity that could be imparted into the story. An experimental evaluation is undertaken in order to test the generated narratives by our system, corresponding to the different input levels of non-linearity, in terms of engagement. We have obtained results that, for the story employed, increasing the non-linearity up to a medium level did not produce any change in the difficulty in comprehension and thus contributing to engagement. However, it was observed that higher levels of non-linearity led to a decrease in engagement and that, character inconsistencies present in the story had a negative affect on the engagement of the material.
A variable exponent diffusion problem of concave-convex nature

We deal with the problem $$ \begin{cases} -\Delta u = \lambda u^{q(x)} & \text{if } x\in \Omega,\\ u = 0 & \text{if } x\in \p\Omega, \end{cases} $$ where $\Omega\subset \R^N$ is a bounded smooth domain, $\lambda\gt 0$ is a parameter and the exponent $q(x)$ is a continuous positive function that takes values both greater than and less than one in $\overline{\Omega}$. It is therefore a kind of concave-convex problem where the presence of the interphase $q=1$ in $\overline{\Omega}$ poses some new difficulties to be tackled. The results proved in this work are the existence of $\lambda^* \gt 0$ such that no positive solutions are possible for $\lambda \gt \lambda^*$, the existence and structural properties of a branch of minimal solutions, $u_\lambda$, $0 \lt \lambda \lt \lambda^*$, and, finally, the existence for all $ \lambda \in (0,\lambda^*)$ of a second positive solution.
Effects of a daily 3-meal pattern with different dietary protein contents on pig growth performance , carcass and muscle quality traits Short title : Feed pattern affects carcass and muscle quality traits

BACKGROUND Recent research related to phase-feeding programs for pig nutrition do not always account for the variation among individuals, and feeds are usually formulated to optimize the performance of the whole pig population. This study aimed at measuring the effects of a daily 3-meal pattern with different dietary protein contents on pig growth performance, carcass and muscle quality traits. RESULTS This article is protected by copyright. All rights reserved. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/jsfa.8367 A cc ep te d A rti cl e The results showed that compared with the 3C treatment, ADG of pigs in the HCL treatment increased by 14.75% (P < 0.05) during period 1. The carcass weight (P = 0.006) and slaughter weight (P = 0.021) in the HCL group increased when compared with those in the 3C and LCH treatments. Moreover, the LCH feeding sequences contributed to reduce the drip loss in longissimus dorsi (LD) muscle (P < 0.05) when compared with the 3C treatment. The HCL or LCH feeding sequence contributed to increase the meat quality when compared with those receiving the 3C treatment. CONCLUSION Collectively, our results indicate that feeding high protein meal in the morning and a gradual reduction of the protein content in meals over the day may improve muscle quality characteristics, maximize performance, and reduce the pig feed cost.
The Impacts of Ownership Structure on Capital Structure and Firm’s Performance in Nigeria

This research is aimed at determining the relationship between corporate governance and capital structure while the impact of this relationship on value of the firm using the panel data of selected Nigerian large non financial firms was also investigated. A contrasting relationship was observed between capital structure and the firm’s performance while Nigerian firm’s capital structure was dominated by short term leverage. Leverage was negatively related to return on assets, number of board meetings and the board size while it was positively related to board composition. It was also observed that firm’s performance was positively related to leverage, number of board meetings and board size while it was negatively related to board composition. Keywords: Capital structure, Value of the firm, Leverage, Corporate governance.
Title Portfolio optimization in a regime-switching market withderivatives

We consider the optimal asset allocation problem in a continuous-time regime-switching market. The problem is to maximize the expected utility of the terminal wealth of a portfolio that contains an option, an underlying stock and a risk-free bond. The difficulty that arises in our setting is finding a way to represent the return of the option by the returns of the stock and the risk-free bond in an incomplete regime-switching market. To overcome this difficulty, we introduce a functional operator to generate a sequence of value functions, and then show that the optimal value function is the limit of this sequence. The explicit form of each function in the sequence can be obtained by solving an auxiliary portfolio optimization problem in a single-regime market. And then the original optimal value function can be approximated by taking the limit. Additionally, we can also show that the optimal value function is a solution to a dynamic programming equation, which leads to the explicit forms for the optimal value function and the optimal portfolio process. Furthermore, we demonstrate that, as long as the current state of the Markov chain is given, it is still optimal for an investor in a multiple-regime market to simply allocate his/her wealth in the same way as in a single-regime market.
Determinants of Customer Relationship Management (CRM): A Conceptual Analysis

The study aims to examine various literatures on CRM determinants and effectiveness to adapt perfect strategy and policy for service oriented organizations. It also aspires to identify the relative importance of CRM determinants analysis as one of the most important factors which influence the organization directly. To comply with the objective, an exploratory research approach based on archive method has been adopted to identify the CRM key determinants and effectiveness factors through literature review. Our initial research model is derived from two areas of the literature: CRM key elements and CRM performance effectiveness. Furthermore, we introduce a new framework for evaluating existing business process from Bangladesh perspective.
Aortic Coarctation Diagnosed ToF at the age of 3 associated with ligation of patent During Pregnancy in a Woman With Repaired Tetralogy of Fallot

Aortic coarctation is thought to be a rare condition in patients with tetralogy of Fallot. We report the case of a 26 year old woman presenting with systemic hypertension at 17 weeks of pregnancy after repair of tetralogy of Fallot in childhood. Echocardiography and magnetic resonance imaging revealed right aortic arch with severe isthmic coarctation. Her blood pressure was controlled medically during the rest of her pregnancy, and delivery was uneventful. Successful transcatheter placement of a covered stent at the level of the coarctation was performed after delivery. To our knowledge, this is the first reported case of aortic coarctation diagnosed in an adult patient late after repair of tetralogy of Fallot. (Ann Thorac Surg 2015;100:e45–7) 2015 by The Society of Thoracic Surgeons
The Minimalist Program and the concept of Universal Grammar

This volume offers a collection of brief and orginal articles that aim at developing the minimalist approach to language. In this introduction, we would like to discuss certain issues concerning the Minimalist Program and the concept of Universal Grammar as well as to present the contributions of the volume. The term minimalism is typically associated to certain artistic tendencies whose work is said to be stripped down to its most fundamental features. In the linguistic agenda developed by Noam Chomsky and others since the early nineties, this term is endowed with the same aesthetic concern of searching for the most fundamental features of grammatical theory, but it crucially adds a substantive commitment to investigate to what extent language is—in a sense we clarify below—a perfect system.
Optimal human navigation in steep terrain: a Hamilton–Jacobi–Bellman approach

We present a method for determining optimal walking paths in steep terrain using the level set method and an optimal control formulation. By viewing the walking direction as a control variable, we can determine the optimal control by solving a Hamilton-Jacobi-Bellman equation. We then calculate the optimal walking path by solving an ordinary differential equation. We demonstrate the effectiveness of our method by computing optimal paths which travel throughout mountainous regions of Yosemite National Park. We include details regarding the numerical implementation of our model and address a specific application of a law enforcement agency patrolling a nationally protected area.
Lower limits to metal-semiconductor contact resistance: Theoretical models and experimental data

We calculate the minimum feasible contact resistivity to n-type and p-type In0.53Ga0. 47As, InAs, GaAs, GaSb, InP, and InSb. The calculations consider image force lowering and assume either parabolic or non-parabolic energy dispersion in the semiconductor; their results are compared with recent experimental data. Among significant results, the measured contact resistivity to n-In0.53Ga0. 47As at a carrier concentration of 5 × 1019 cm−3 is only 2.3:1 higher than that calculated assuming a 0.2 eV barrier potential, and the measured contact resistivity is only 9.0:1 larger than the Landauer quantum conductivity limit at this carrier concentration. These results indicate that, with the surface preparation procedures presently employed, surface contamination does not markedly increase the interface resistance, and that the transmission coefficient for carriers crossing the interface exceeds 10%.
ETEROGENEITY OF GLUTAMATERGIC AND GABAergic RELEASE ACHINERY IN CEREBRAL CORTEX : ANALYSIS OF SYNAPTOGYRIN

bstract—To define whether cortical glutamatergic and ABAergic release machineries can be differentiated on the asis of the nature and amount of proteins they express, we tudied the degree of co-localization of synaptogyrin (SGYR) and 3, vesicle-associated membrane protein (VAMP) 1 and , syntaxin (STX) 1A and 1B in vesicular glutamate transorter (VGLUT)1-, VGLUT2and vesicular GABA transporter VGAT)-positive ( ) puncta and synaptic vesicles in the rat erebral cortex. Co-localization studies showed that SGYR1 nd 3 were expressed in about 90% of VGLUT1 , 70% of GLUT2 and 80% of VGAT puncta; VAMP1 was expressed n approximately 45% of VGLUT1 , 55% of VGLUT2 , and 0% of VGAT puncta; VAMP2 in about 95% of VGLUT1 , 5% of VGLUT2 , and 80% of VGAT puncta; STX1A in bout 65% of VGLUT1 , 30% of VGLUT2 , and 3% of VGAT uncta, and STX1B in approximately 45% of VGLUT1 , 35% f VGLUT2 , and 70% of VGAT puncta. Immunoisolation tudies showed that while STX1A was completely segregated nd virtually absent from VGAT synaptic vesicles, STX1B, AMP1/VAMP2, SGYR1/SGYR3 showed a similar pattern with he highest expression in VGLUT1 immunoisolated vesicles nd the lowest in VGAT immunoisolated vesicles. Moreover, e studied the localization of STX1B at the electron microcope and found that a population of axon terminals forming ymmetric synapses were STX1B-positive.These results exend our previous observations on the differential expression f presynaptic proteins involved in neurotransmitter release n GABAergic and glutamatergic terminals and indicate that eterogeneity of glutamatergic and GABAergic release mahinery can be contributed by both the presence or absence f a given protein in a nerve terminal and the amount of
Nitrogen-isotope record of fluid-rock interactions in the Skiddaw Aureole and granite, English Lake District

Abstract The Skiddaw Granite and its contact metamorphic aureole in the English Lake District provide an excellent opportunity to test the capability of the N-isotope system to trace devolatilization and large- scale transfer of crustal fluids. In the aureole, Skiddaw Group metasedimentary rocks with relatively uniform lithology and major-element compositions show a dramatic decrease in N content toward the granite contact (from ≥ 800 ppm at distances >2.5 km from the contact, to <410 ppm ≤0.55 km from the contact). Far from the intrusive body (>1.5 km), these rocks have extremely uniform δ15Nair near +3.7‰, whereas closer to the contact (≤1 km) δ15N is shifted to higher values (up to +8.7‰). The coupled decreases in N content and increases in δ15N are compatible with the removal of N having low δ15N in fluids during continuous, prograde devolatilization reactions involving the breakdown of white mica and the stabilization of biotite-, cordierite-, and andalusite-bearing assemblages. In the same metasedimentary rocks, the lack of obvious trends in major-element concentrations (including SiO2/TiO2, SiO2/Al2O3, and the ratios of other major oxides to TiO2 and Al2O3) with distance from the granitic contact is consistent with minimal change in major element composition during the contact metamorphism. Ratios of whole-rock N, B, Rb, and Ba concentrations to whole-rock K2O content are believed to reflect the differing fluid-mica partitioning (and involving varying relative proportions of white mica and biotite) of these trace elements during devolatilization reactions. Greisenized Skiddaw Granite from a borehole is enriched in N (range of 17-225 ppm for whole rocks and white mica separates) relative to the unaltered granite (whole-rock <30 ppm), and has δ15N of+1.0 to +4.8‰. The N concentrations and δ15N of the wall-rocks and greisenized granites, combined with C isotopic data (carbonate and carbonaceous matter) for the same rocks, are consistent with the mobilization of fluids having low δ15N and δ13CPDB values from the devolatilized aureole into the cooling intrusive body. Such transport is consistent with the predictions of recent theoretical models of late-stage hydrothermal evolution in cooling intrusive systems.
Some explicit identities for the modified higher-order degenerate q-Euler polynomials and their zeroes

Recently, Kim et al. [D. S. Kim, T. Kim, Ars Combin. , 126 (2016), 435–441], [D. S. Kim, T. Kim, J. Nonlinear Sci. Appl. , 9 (2016), 443–451], [T. Kim, D. S. Kim, H. -I. Kwon, Filomat, 30 (2016), 905–912] and [T. Kim, D. S. Kim, H. -I. Kwon, J.-J. Seo, D. V. Dolgy, J. Nonlinear Sci. Appl. , 9 (2016), 1077–1082] studied symmetric identities of higher-order degenerate q-Euler polynomials. In this paper, we define the modified higher-order degenerate q-Euler polynomials and give some identities for these polynomials. Also we give numerical investigations of the zeroes of the modified higher-order q-Euler polynomials and the zeroes of the modified higher-order degenerate q-Euler polynomials. Furthermore, we demonstrate the shapes and zeroes of the modified higher-order q-Euler polynomials and the modified higher-order degenerate q-Euler polynomials by using a computer. c ©2017 All rights reserved.
Molecular and Cellular Pathobiology PML-RAR a and Its Phosphorylation Regulate PML Oligomerization and HIPK 2 Stability

The PML gene is frequently fused to the retinoic acid receptor a (RARa) gene in acute promyelocytic leukemia (APL), generating a characteristic PML-RARa oncogenic chimera. PML-RARa disrupts the discrete nuclear speckles termed nuclear bodies, which are formed in PML, suggesting that nuclear body disruption is involved in leukemogenesis. Nuclear body formation that relies upon PML oligomerization and its stabilization of the hypoxia-inducible protein kinase (HIPK)-2 is disrupted by expression of the PML-RARa chimera. Here, we report that disruption of nuclear bodies is also mediated by PML-RARa inhibition of PML oligomerization. PKAmediated phosphorylation of PML-RARa blocked its ability to inhibit PML oligomerization and destabilize HIPK2. Our results establish that both PML oligomerization and HIPK2 stabilization at nuclear bodies are important for APL cell differentiation, offering insights into the basis for the most common prodifferentiation therapies of APL used clinically. Cancer Res; 73(14); 4278–88. 2013 AACR.
1_2 Milena Jovicic.qxp

In transition literature until now, the relative probability of lay-offs between the public and the private sector has been stressed as the crucial factor that determines the success or failure of transition1. The following arguments were established: when the risk of being laid off is higher in the public sector, the transformation is necessarily achieved, eventually with an overshooting of unemployment. On the other hand, where jobs are more secure in the state firms, transition is more likely to derail, since the slow reallocation of labour from the state sector then impedes the private sector development. The view of transition offered by the optimal speed of transition (OST) models is of an “evolutionary” process of reallocation. The OST literature advocates gradual phasing out of the state sector as optimal2. The growth of the private sector is driven by capital accumulation, i.e. savings. Too fast a rate of scrapping of the state sector leads to savings reduction and therefore slows down job creation in the new private firms. On the other hand, if job destruction in the old state sector is too slow, accompanied by soft budget constraints, this forces the private sector to pull workers from their old jobs by increasing wages, thereby slowing
Comparison of Switching Methods for Asymmetric Cascaded H- Bridge Multilevel Inverter

Recently, multilevel inverters using for medium voltage drive are controlled with various modulation techniques. Although we have seen in Asymmetric Cascaded H-Bridge topologies having unequal input dc voltages significant improvement than others, its switching is complex. In this study all three applicable methods on Asymmetric CHB, SHE, NLC and Multi-carrier, are analyzed. In multi-carrier switching method for this topology the number of subject switches is less than carriers. We introduce equations for combine the PWMs to use the controllability advantage of the multi-carrier method in asymmetric topology. Comparing these methods shows although the SHE and NLC have lower THD; they are Off-Line methods and are not applicant for closed-loop systems. Finally, results indicate that multi-carrier method has an appropriate harmonic function and has advantage rather than two other switching methods for asymmetric multi-level inverter respect to its Online nature.