Miracle-dz/UniFAR-FTUs huggingface dataset:
[Prevention of the musculoskeletal system's dysfunction based on the example of Prevention Program of Spinal Pain Syndrome in Nursing Staff].

BACKGROUND Most of the medical activities, which are work-related, both static and dynamic are performed by nurses in a forced position. Excessive and improper strain of the musculoskeletal system, especially when lifting and moving patients, is the cause of many injuries of the musculoskeletal system. The work presents the implementation and evaluation of the program concerning the prevention of dysfunction on the part of the musculoskeletal system, addressed to professionally active nurses. MATERIAL AND METHODS The questionnaire was addressed to 125 professionally active nurses, working in conservative units (92%) and outpatient care (8%), suffering from musculoskeletal system dysfunctions, qualifying for the preventive program (ultimately 65 respondents joined the program). The research method was a diagnostic survey, using: the World Health Organization Quality of Life-BREF (WHOQOL-BREF) (scale results are in the range of 4-20 pts), 5-point scale to assess the frequency and intensity of pain and body mass index (BMI). RESULTS The average age of the studied group is 46.6 years old (±8.6), work experience 24.3 (±9.8). A total of 57% of respondents reported pain in the musculoskeletal system, the vast majority of which affected the lumbar spine (89.2%). Constantly occurring complaints were characteristic for nurses, whose average age was 49.5 years (p = 0.0001) and with work experience over 27 years (p = 0.0002), with a BMI value (≥ 25) (p = 0.0038). The average quality of life results were significantly dependent on the intensity of pain (p < 0.05). CONCLUSIONS The research shows that pain, escalating with age and duration of the professional activity is a significant factor in lowering the quality of nurses' life. The severity and frequency of experienced ailments significantly decreased after participating in kinesitherapeutic activities. Med Pr. 2019;70(2)189-99.
FKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts

Osteoclasts employ highly specialized intracellular trafficking controls for bone resorption and organelle homeostasis. The sorting nexin Snx10 is a (Phosphatidylinositol 3‐phosphate) PI3P‐binding protein, which localizes to osteoclast early endosomes. Osteoclasts from humans and mice lacking functional Snx10 are severely dysfunctional. They show marked impairments in endocytosis, extracellular acidification, ruffled border formation, and bone resorption, suggesting that Snx10 regulates membrane trafficking. To better understand how SNx10 regulates vesicular formation and trafficking in osteoclasts, we set out on a search for Snx10 partners. We performed a yeast two‐hybrid screening and identified FKBP12. FKBP12 is expressed in receptor activator of nuclear factor kB ligand–stimulated RAW264.7 monocytes, coimmunoprecipitates with Snx10, and colocalizes with Snx10 in osteoclasts. We also found that FKBP12, Snx10, and early endosome antigen 1 (EEA1) are present in the same subcellular fractions obtained by centrifugation in sucrose gradients, which confirms localization of FKBP12 to early endosomes. Taken together, these results indicate that Snx10 and FKBP12 are partners and suggest that Snx10 and FKBP12 are involved in the regulation of endosome/lysosome homeostasis via the synthesis. These findings may suggest novel therapeutic approaches to control bone loss by targeting essential steps in osteoclast membrane trafficking.
Social network characteristics and their associations with stress in older adults: Closure and balance in a population-based sample.

OBJECTIVES Integration into social networks reduces stress during adverse life-events and improves coping with disability in late life. The aim is to investigate whether social network closure (frequent contact among ties) and balance (positive contact among ties) are associated with perceived stress. We expect lowest stress for older adults with highly closed and balanced networks. METHOD Panel data on self-reported egocentric networks stem from the population-based Chicago Health Aging and Social Relations Study (CHASRS). Five waves were collected between 2002 and 2006, with 708 observations from 160 participants aged 50-68 years at baseline. Data include information on the participants' social relationships, i.e., interaction frequency and relationship quality, for ego-alter ties and alter-alter ties, and participants' perceived stress. The analytical strategy employed fixed- and random-effects models. RESULTS Participants reporting the highest number of balanced relationships (positive ties among alters) experience least stress. This effect holds independently of socio-demographic confounders, loneliness and network size.
Seasonal Linear Predictivity in National Football Championships

Predicting the results of sport matches and competitions is a growing research field, benefiting from the increasing amount of available data and novel data analytics techniques. Excellent forecasts can be achieved by advanced statistical and machine learning methods applied to detailed historical data, especially in very popular sports such as football (soccer). Here, we show that despite the large number of confounding factors, the results of a football team in longer competitions (e.g., a national league) follow a basically linear trend that is also useful for predictive purposes. In support of this claim, we present a set of experiments of linear regression compared to alternative approaches on a database collecting the yearly results of 746 teams playing in 22 divisions spanning up to five different levels from 11 countries, in 25 football seasons, for a total of 181,160 matches grouped in 9386 seasonal time series.
Molecular Origin of the Elastic State of Aqueous Hyaluronic Acid

The macroscopic mechanical properties of biological hydrogels are broadly studied and successfully mimicked in synthetic materials, but little is known about the molecular interactions that mediate these properties. Here, we use two-dimensional infrared spectroscopy to study the pH-induced gelation of hyaluronic acid, a ubiquitous biopolymer, which undergoes a transition from a viscous to an elastic state in a narrow pH range around 2.5. We find that the gelation originates from the enhanced formation of strong interchain connections, consisting of a double amide–COOH hydrogen bond and an N–D–COO– hydrogen bond on the adjacent sugars of the hyaluronan disaccharide unit. We confirm the enhanced interchain connectivity in the elastic state by atomic force microscopy imaging.
How clonal are clones? A quest for loss of heterozygosity during asexual reproduction in Daphnia magna

Due to the lack of recombination, asexual organisms are predicted to accumulate mutations and show high levels of within‐individual allelic divergence (heterozygosity); however, empirical evidence for this prediction is largely missing. Instead, evidence of genome homogenization during asexual reproduction is accumulating. Ameiotic crossover recombination is a mechanism that could lead to long genomic stretches of loss of heterozygosity (LOH) and unmasking of mutations that have little or no effect in heterozygous state. Therefore, LOH might be an important force for inducing variation among asexual offspring and may contribute to the limited longevity of asexual lineages. To investigate the genetic consequences of asexuality, here we used high‐throughput sequencing of Daphnia magna for assessing the rate of LOH over a single generation of asexual reproduction. Comparing parthenogenetic daughters with their mothers at several thousand genetic markers generated by restriction site‐associated DNA (RAD) sequencing resulted in high LOH rate estimation that largely overlapped with our estimates for the error rate. To distinguish these two, we Sanger re‐sequenced the top 17 candidate RAD‐loci for LOH, and all of them proved to be false positives. Hence, even though we cannot exclude the possibility that short stretches of LOH occur in genomic regions not covered by our markers, we conclude that LOH does not occur frequently during asexual reproduction in D. magna and ameiotic crossovers are very rare or absent. This finding suggests that clonal lineages of D. magna will remain genetically homogeneous at least over time periods typically relevant for experimental work.
Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy

Increased risk of colorectal cancer (CRC) is associated with altered intestinal microbiota as well as short‐chain fatty acids (SCFAs) reduction of output The energy source of colon cells relies mainly on three SCFAs, namely butyrate (BT), propionate, and acetate, while CRC transformed cells rely mainly on aerobic glycolysis to provide energy. This review summarizes recent research results for dysregulated glucose metabolism of SCFAs, which could be initiated by gut microbiome of CRC. Moreover, the relationship between SCFA transporters and glycolysis, which may correlate with the initiation and progression of CRC, are also discussed. Additionally, this review explores the linkage of BT to transport of SCFAs expressions between normal and cancerous colonocyte cell growth for tumorigenesis inhibition in CRC. Furthermore, the link between gut microbiota and SCFAs in the metabolism of CRC, in addition, the proteins and genes related to SCFAs‐mediated signaling pathways, coupled with their correlation with the initiation and progression of CRC are also discussed. Therefore, targeting the SCFA transporters to regulate lactate generation and export of BT, as well as applying SCFAs or gut microbiota and natural compounds for chemoprevention may be clinically useful for CRCs treatment. Future research should focus on the combination these therapeutic agents with metabolic inhibitors to effectively target the tumor SCFAs and regulate the bacterial ecology for activation of potent anticancer effect, which may provide more effective application prospect for CRC therapy.
Addressing the room for improvement in management of acute promyelocytic leukemia

Acute promyelocytic leukemia (APL) is highly curable. To achieve high cure rates, targeted therapy with retinoic acid (ATRA) must be started promptly at time of suspected diagnosis. Early death rates (EDRs, ≤30 days from diagnosis) differ markedly in patients treated on clinical trials compared to the general population.
Acupuncture-associated infections: A matter of concern in China

Pengcheng Zhou MD12, Yuhua Chen MSN2, Bizhen Chen MSN3, Yaowang Wang MSN2, Xun Huang MD2 and Xue-Gong Fan MD1 1Hunan Key Laboratory of Viral Hepatitis and Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China, 2Infection Control Center, Xiangya Hospital, Central South University, Changsha, Hunan, China and 3Department of Infection Control, The Second Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China
Comparative Studies On Muscle Lipid Fatty Acid Profiles Of Some Cultured Indian Carp Species

The Polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), help in preventing coronary heart disease. These fatty acids play an important role in reducing the risk of colon, breast and prostate cancer. Although, carps form the major chunk of harvested fish worldwide, the information about their fatty acid profiles is meager.The present study was conducted to know the seasonal variations on muscle total lipid content (MTLC) and fatty acid profiles of three Indian carp species, Labeo. rohita(Ham.), Catla. catla (Ham.) and Cirrhinusmrigala (Ham.). The MTLC varied within the species of fish (1.06±0.02% in C. mrigala to 3.00±0.06% in C. catla) and season of the year. The minima were recorded during spring except C . mrigala (summer) and maxima during winter in all species. The total PUFAs highest in C. catla (23.21±3.67%) and minimum in C. mrigala (18.50±4.95%). The mean ratio of n3/n6 was highest (1.49) in C. catla and lowest (0.89) in C. mrigala.
A genetic switch : phage λ and higher organisms

1. The Master Elements of Control:Components of the SwitchThe Action of Repressor and CroInduction - Flipping the SwitchCooperativity - Switch Stability and SensitivityThe Effect of AutoregulationOther Cases2. Protein-DNA Interactions and Gene Control:The OperatorRepressorCroAmino Acid-Base Pair InteractionsThe PromoterGene Control3. Control Circuits - Setting the Switch:A Brief Overview of Lambda GrowthControl of TranscriptionThe DecisionControl of Integration and ExcisionOther PhagesThe SOS ResponsePathways and Cell Development4. How do we Know - The Key Experiments:The Repressor IdeaThe Repressor Problem in the Early 1960sRepressor Isolation and DNA-BindingMaking More RepressorThe Claims of Chapters One and Two5. Eukaryotic Gene Regulation - An Overview:IntroductionEukaryotic Genes and their PolymerasesActivationRepressionCooperativityRegulators Assembled for Non-identical ComponentsSpeculations on Development and EvolutionCaveats6. Eukaryotic Gene Regulation - Experiments and Examples:BackgroundTwo Functions of an Activator: DNA Binding and ActivationDNA Binding StructuresActivating RegionsAction at a Distance- LoopingActivation In Vivo and In VitroSquelchingRepressionRegulators Assembled from Non-identical ComponentsMore CooperativityThe Case of EveConclusion Appendix OneDesigning an Efficient DNA-binding ProteinAppendix TwoStrong and Weak InteractionsAppendix ThreeControl of Transcription in Eukaryotes and Prokaryotes - a common mechanism
Performa dan Kandungan Hormon Triiodotironin Plasma Ayam Broiler Akibat Pengaruh Cekaman Panas di Daerah Tropis

High environmental temperature may cause heat stress in poultry. This may increase water consumption, decrease feed intake and in turn, decrease production and triiodothyronine hormone level. The aim of the experiment was to study performance and plasma triiodothyronine hormone of broilers exposed to heat stress in tropical area. The study used 140 male broilers of 2 weeks of age. The treatment of environmental temperatures were S1A (28.55? 1.53 o C) with ad libitum of feeding, S1BT1 (S1 with pair feeding as S2A), S1BT2 (S1 with pair feeding as S3A), S2A (31.07? 1.29 o C) with ad libitum of feeding and S3A (33.50? 1.17 o C) with ad libitum of feeding. Variables measured were feed consumption, body weight gain, feed conversion and triiodothyronine hormone level of plasma. The experiment design used was a completely randomized design with 4 replications and continued to Duncan test when it was significantly different. The results indicated that feed consumption and body weight gain in S1A, higher than those in S2A and S3A. The body weight gain in S1BT1 higher than those in S2A, and in S1BT2 higher than those in S3A. The level of plasma triiodothyronine hormone in S1, S1BT1 and S1BT2 was higher than those in S2A and in S3A. Key words: heat stress, body weight gain, triiodothyronine hormone
Breeding Sites of the Australian Pelican 'Pelecanus conspicillatus' in Victoria

Published records and all available unpublished records of breeding by the Australian Pelican 'Pelecanus conspicillatus' in Victoria have been critically assessed. Authentic records (i.e. those with details of nests, eggs and/or young) indicate that this species has bred at only eight locations since 1970 and at two additional locations before this. Two of these 10 locations (Lake Buloke and the Gippsland Lakes) had not been used before 1996, five have been used frequently, and the remainder have been used only intermittently. Although the breeding population of Pelicans fluctuates widely between years, the presence of the Pelican as a breeding waterbird in Victoria seems to be secure as it is able to utilise new sites when conditions become conducive to nesting. In Victoria, the sites used regularly are all on semi-permanent or permanent saline wetlands, typically on small islands in coastal lakes or embayments. Freshwater wetlands are sometimes used when islands and a reliable fish supply are present. There are only two locations (Mud Islands and Lake Corangamite) that have been used within the last 4 years for breeding, and there appears to have been a shift in breeding from French Island in Western Port to Mud Islands in Port Phillip Bay. Pelicans are vulnerable to disturbance at all Victorian breeding sites.
Antimicrobial properties and phytochemical constituents of the metha-nol extracts of Euphorbia retusa Forssk. and Euphorbia terracina L. from Saudi Arabia

A B S T R A C T This study aimed to investigate the phytochemical constituents and antimicrobial activities of the crude methanol extracts of leaves of Euphorbia retusa Forssk and Euphorbia terracina L. collected from Saudi Arabia (Al-Rass province). Extracts of both plants showed presence of some bioactive phytochemicals such as tannins, saponins, terpenoids and traces of alkaloids for E. terracina; and tannins, saponins, flavonoids, alkaloids and terpenoids for E. retusa. Among investigated microorganisms, methanol extracts exhibited some degree of antimicrobial activity towards some microorganisms; namely,Candida albicans ATCC 1405, Staphylococcus epidermidis ATCC 49461, Bacillus cereus ATCC 10876 and Klebsiella pneumonia ATCC 27736 respectively for E. retusa and towards Staphylococcus aureus ATCC 25923.Staphylococcus epidermidis ATCC 49461,Candida albicans ATCC 1405,Bacillus cereus ATCC 10876 and Klebsiella pneumonia ATCC 27736 respectively for E. terracina. MIC testing was ranged from 100 to 6.2 mg/ml, proving the antimicrobial potency of these plants’ extracts against some microorganisms. Further studies regarding purification and fractionation are required since the antimicrobial activities of tested extracts were not competitor when compared to the antibiotics Chloramphenicol 25mg/ml or Clotrimazole 10 mg/ml.
Preliminary Discrimination of Butter Adulteration by ATR-FTIR Spectroscopy

The Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR) Â was applied for the discrimination of butter samples adulterated with solid fraction of palm oil. For FTIR fingerprinting of butter samples, with or without controlled additions of palm oil as adulterant was firstly obtained, using a Shimatsu Prestige 21 Spectrophotometer, including a horizontal diamond ATR accessory with reflection in the MIR region (3873-690) cm -1 . The spiked butter samples including 0 level and seven increasing concentrations of palm fats, up to 50% were fingerprinted and the calibration curve was obtained (n=19). In parallel, the validation was realized using different set of spiked butter samples ranging 1-44.4 % of palm fat (n=7). Finally, an independent set of commercial samples was analized (n=14). Partial least squares (PLS) model was used for statistical data processing in accordance with standard method. The value of the correlation coefficient (R 2 = 0.977) between actual and predicted values was statistically significant (p<0.001), considering the superposition of Â "actual vs predictedâ€ curves. This combined FTIR-PLS evaluation revealed that 3 out ofÂ samples of butter were suspected of adulteration with palm oil, presented values 14 ranging 4-12%. In conclusion, ATR-FTIR methodology may offer an rapid evaluation of Â butter samples authenticity. The low value for detection limit (3%palm oil in butter) and the low limit of quantification (9.8% palm oil in butter) confirms that ATR-FTIR spectroscopy Â is a sensitive method to identify the adulteration of butter with Â palm oil. Â Â
The Identity of the Fungus Causing Anthracnose of Olives in South Africa.

In South Africa all the diseases that affect olive trees are of fungal origin (G orter, 1959). O f these, anthracnose is perhaps the m ost destructive. The fruit-decay for which it is responsible was know n in the late twenties to occur in the coastal regions o f the western Cape Province (Verwoerd, 1928). I t was not before 1935, however, tha t the cause of the disease was identified as an anthracnose fungus o f the Gloeosporium type. *
Historical Demography of Iceland

Knowledge of the seasonal variation in births and deaths during normal years is important for analyses of the effects of wars, famines, epidemics or similar privations on these variables. In studies of seasonality, multiple trigonometric regression models are more flexible than the simple sine curve. The seasonal variation in mortality in Iceland, 1856-1990, shows a strong secular decrease, and a connection between this and the epidemiological transition is considered. Comparisons with findings in other European countries are made. The temporal trends in Iceland of the birth components; the twinning rate, the still birth rate and the secondary sex ratio, are presented and compared with the corresponding values in neighbouring countries. No marked differences were emerged.
Fas Resistance of Leukemic Eosinophils Is Due to Activation of NF-κB by Fas Ligation1

TNF family receptors can lead to the activation of NF-κB and this can be a prosurvival signal in some cells. Although activation of NF-κB by ligation of Fas (CD95/Apo-1), a member of the TNFR family, has been observed in a few studies, Fas-mediated NF-κB activation has not previously been shown to protect cells from apoptosis. We examined the Fas-induced NF-κB activation and its antiapoptotic effects in a leukemic eosinophil cell line, AML14.3D10, an AML14 subline resistant to Fas-mediated apoptosis. EMSA and supershift assays showed that agonist anti-Fas (CH11) induced nuclear translocation of NF-κB heterodimer p65(RelA)/p50 in these cells in both a time- and dose-dependent fashion. The influence of NF-κB on the induction of apoptosis was studied using pharmacological proteasome inhibitors and an inhibitor of IκBα phosphorylation to block IκBα dissociation and degradation. These inhibitors at least partially inhibited NF-κB activation and augmented CH11-induced cell death. Stable transfection and overexpression of IκBα in 3D10 cells inhibited CH11-induced NF-κB activation and completely abrogated Fas resistance. Increases in caspase-8 and caspase-3 cleavage induced by CH11 and in consequent apoptotic killing were observed in these cells. Furthermore, while Fas-stimulation of resistant control 3D10 cells led to increases in the antiapoptotic proteins cellular inhibitor of apoptosis protein-1 and X-linked inhibitor of apoptosis protein, Fas-induced apoptosis in IκBα-overexpressing cells led to the down-modulation of both of these proteins, as well as that of the Bcl-2 family protein, Bcl-xL. These data suggest that the resistance of these leukemic eosinophils to Fas-mediated killing is due to induced NF-κB activation.
The Chimpanzee Genome--A Bittersweet Celebration

Deciphering human uniqueness by comparing the chimpanzee and human genomes is a fascinating but tough task, according to Olson and Varki in their Perspective. Reporting on a recent symposium at the University of California, San Diego, Olson and Varki provide an update on intriguing differences between humans and chimps at the molecular level.