Miracle-dz/UniFAR-FTUs huggingface dataset:
COSSMO: predicting competitive alternative splice site selection using deep learning

Motivation Alternative splice site selection is inherently competitive and the probability of a given splice site to be used also depends strongly on the strength of neighboring sites. Here we present a new model named Competitive Splice Site Model (COSSMO), which explicitly models these competitive effects and predict the PSI distribution over any number of putative splice sites. We model an alternative splicing event as the choice of a 3’ acceptor site conditional on a fixed upstream 5’ donor site, or the choice of a 5’ donor site conditional on a fixed 3’ acceptor site. We build four different architectures that use convolutional layers, communication layers, LSTMS, and residual networks, respectively, to learn relevant motifs from sequence alone. We also construct a new dataset from genome annotations and RNA-Seq read data that we use to train our model. Results COSSMO is able to predict the most frequently used splice site with an accuracy of 70% on unseen test data, and achieve an R2 of 60% in modeling the PSI distribution. We visualize the motifs that COSSMO learns from sequence and show that COSSMO recognizes the consensus splice site sequences as well as many known splicing factors with high specificity. Availability Our dataset is available from http://cossmo.deepgenomics.com. Contact frey@deepgenomics.com Supplementary information Supplementary data are available at Bioinformatics online.
P4.1 - Drahtlose energieautarke RFID-Sensorik im Motorraum von Kraftfahrzeugen

Heutige verbaute konventionelle Sensoren in Kraftfahrzeug haben eine drahtgebundene externe Energieversorgung sowie Signalleitungen zur Kommunikation. Fur die Entwicklung der nachsten Generation werden kostendampfende Masnahmen bestimmend sein, welche entweder durch Produktund Produktionsoptimierung oder durch den Einsatz neuartiger autarker Sensorsysteme erzielt werden konnen. In diesem Beitrag wird ein innovatives Konzept zur Integration drahtloser energieautarker Sensorknoten im Motorraum vorgestellt, bei dem die Energieund Datenubertragung mithilfe der RFID-Technologie realisiert wird. Als RFID-Basisstation dient ein zentrales Steuergerat mit einer HF-geeigneten Antennenstruktur, welche beispielsweise im Dammmaterial der Motorhaube integriert ist. Diese Basisstation ermoglicht eine Erfassung von Messdaten unterschiedlicher Sensorknoten im gesamten Motorraum und ubermittelt die gewonnen Informationen an einen fahrzeuginternen Kommunikationsbus. Das Hauptziel der Entwicklung stellen autarke Sensorsysteme zur aktiven Erfassung von Messgrosen mit geringen Latenzzeitanforderungen, wie beispielsweise Fullstanden, Temperaturen etc., dar. Neben den aktiven Sensorsystemen konnen die Sensorknoten auch ohne aktive Messaufgaben rein passiv als RFID-Etiketten ausgelegt sein, z.B. zur Erkennung von inkompatiblen Austauschteilen.
experience Network models for large cities : the European

http://heart.bmj. com/content/96/2/164.full. html Updated information and services can be found at: These include: References http://heart.bmj. com/content/96/2/164.full. html#ref-list-1 This article cites 31 articles, 23 of which can be accessed free at: service Email alerting box at the top right corner of the online article. Receive free email alerts when new articles cite this article. Sign up in the Topic collections (341 articles) Education in Heart  (19 articles) Acute coronary syndromes  Articles on similar topics can be found in the following collections
Leading Question: The Romance Lives On: Contemporary Issues Surrounding the Romance of Leadership

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Statistical analysis of annual maximum daily rainfall for Nelspruit and its environs

Nelspruit and its environs frequently experience extreme high annual maximum daily rainfall (AMDR) events resulting in flood hazards. These flood hazards have caused flood disasters that have resulted in loss of property and lives. The main objective of this study was to carry out statistical analysis of extreme high AMDR events that have caused flood hazards, which in turn have caused flood disasters in Nelspruit and its environs. Empirical continuous probability distribution functions (ECPDF) and theoretical continuous probability distribution functions (TCPDF) were applied to carry out the statistical analysis of the extreme high AMDR events. Annual maximum daily rainfall event of magnitude 100 mm was identified as a threshold. Events > 100 mm were considered as extreme high events resulting in flood disasters. The results of empirical frequency analysis showed that the return period of flood disasters was 10 years. The occurrence probability of flood disaster event at least once in 1, 2, 3, 4 and 5 years was 0.10, 0.19, 0.27, 0.34 and 0.41, respectively. Generalised logistic PDF was identified as the best-fit theoretical PDF for statistical analysis of the extreme high AMDR events in Nelspruit and its environs. The results of this study contributed to the understanding of frequency and magnitude of extreme high AMDR events that could lead to flood disasters. The results could be applied in developing flood disaster management strategies in Nelspruit and its environs.
Interrelationship and Path Coefficient Analysis of Some Growth and Yield Characteristics in Cowpea (Vigna Unguiculata L. Walp) Genotypes

Field experiments were conducted during 2010/2011 to determine the interrelationship and path coefficient analysis of growth characters to seed yield. The experiment was laid out in 7 x 7 triple lattice designs at Haramaya University research farm, Dire Dawa. Seed yield exhibited positive and significant environmental correlation with number of primary branches per plant, number of secondary branches per plant, days to 50% flowering, number of pods per plant, number of seeds per pod and plant height. Path analysis revealed that, yield per plant exerted the maximum positive direct effect on seed yield followed by number of pods per plant, while number of secondary branches per plant, days to flowering, days to maturity and number of seed per pod exhibited negative direct effect phenotypically. In addition, genotypic path analysis revealed that, maximum direct effect on seed yield was exerted by number of pods per plant and yield per plant. However, days to 50% flowering, days to maturity, number of secondary branches per plant and number of seed per pod exerted negative direct effect on seed yield. Thus, yield per plant and number of pods per plant could be used as a selection index for cowpea improvement.
Effect of acute hypobaric hypoxia on skeletal muscle protein turnover

Objective: Present study was designed to investigate the effects of altitude mediated acute hypobaric hypoxia on protein turnover in skeletal muscle. Background: Skeletal muscle wasting is considered to be an important factor leading to decrease in physical performance at high altitude. Changes in protein turnover and the mechanism underlying the loss of skeletal muscle mass under these conditions are not very well understood. Method: Male Sprague Dawley rats (n=12 each group) weighing about 180-200 g were exposed to hypobaric hypoxia (9144 m) for six hours. Skeletal muscle homogenates were prepared for carrying out various studies including proteolytic pathways. Result: Acute exposure to hypobaric hypoxia has deleterious effects on skeletal muscle mass which was reflected by one third attenuation in protein synthesis and more than 50 % increase in protein degradation. Hypobaric hypoxia resulted in upregulation of Ub-Proteasome pathway and calpain whereas lysosomal mediated proteolysis remained unchanged. Glutaminase activity, protein carbonyl status, oxidative stress markers were also found to be elevated in hypoxia exposed rats. Conclusion: These results are indicative of excessive protein degradation and decreased protein synthesis during acute hypobaric hypoxia. Moreover increased protein oxidation may also be an important contributor for the skeletal muscle loss.
DimSUM: Dimension and Scale Unifying Map for Visual Abstraction of DNA Origami Structures

We present a novel visualization concept for DNA origami structures that integrates a multitude of representations into a Dimension and Scale Unifying Map (DimSUM). This novel abstraction map provides means to analyze, smoothly transition between, and interact with many visual representations of the DNA origami structures in an effective way that was not possible before. DNA origami structures are nanoscale objects, which are challenging to model in silico. In our holistic approach we seamlessly combine three‐dimensional realistic shape models, two‐dimensional diagrammatic representations, and ordered alignments in one‐dimensional arrangements, with semantic transitions across many scales. To navigate through this large, two‐dimensional abstraction map we highlight locations that users frequently visit for certain tasks and datasets. Particularly interesting viewpoints can be explicitly saved to optimize the workflow. We have developed DimSUM together with domain scientists specialized in DNA nanotechnology. In the paper we discuss our design decisions for both the visualization and the interaction techniques. We demonstrate two practical use cases in which our approach increases the specialists’ understanding and improves their effectiveness in the analysis. Finally, we discuss the implications of our concept for the use of controlled abstraction in visualization in general.
Role of antidepressants in the treatment of adults with anorexia nervosa

Introduction: Anorexia nervosa (AN) is a severe psychiatric disorder that is difficult to treat and is associated with frequent relapses and high mortality rates. Psychiatric symptomatology (eg, depression, anxiety, obsessive-compulsive disorder/behaviors) are common comorbidities. This review provides current information about safety and efficacy of antidepressant therapy for management of AN in adults. Methods: A literature review of randomized controlled trials, open-label studies, and case reports with adults or adults/adolescents was conducted. PubMed and Medline were searched using anorexia management and treatment, antidepressants, selective serotonin reuptake inhibitors (SSRIs), fluoxetine, sertraline, citalopram, and mirtazapine in AN, relapse prevention in AN, and psychotropic medications in AN. Results: The role and utility of antidepressants in AN were published in double-blind, placebo-controlled studies; open-label trials; and a retrospective study. Antidepressants should not be used as sole therapy for AN although their use for confounding symptomatology makes discerning efficacy difficult as they are given together with other therapies. Neurobiological changes due to starvation and AN itself complicate results interpretation. For safety, tricyclic antidepressants and monoamine oxidase inhibitors are not recommended, and bupropion is contraindicated. Use of SSRIs during acute treatment lacks efficacy. Use of SSRIs—primarily fluoxetine and to some extent citalopram, sertraline, or mirtazapine—may aid in relapse prevention and improvement of psychiatric symptomatology in weight-restored anorexic patients. Discussion: Health care professionals should use clinical judgment regarding fluoxetine or possibly citalopram, sertraline or mirtazapine as adjunctive treatment to psychotherapy for relapse prevention, improvement of depressive and anxiety symptoms, and/or obsessive-compulsive behaviors unresolved with nutritional rehabilitation and psychotherapy.
Long-term functional outcomes after artificial urinary sphincter ( AMS 800 ) implantation in men with stress urinary incontinence

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Long-term functional outcomes after artificial urinary sphincter implantation in men with stress urinary incontinence Priscilla Léon, Emmanuel Chartier-Kastler, Morgan Rouprêt, Vanina Ambrogi, Pierre Mozer, Véronique Phé
Determinants of compassion satisfaction, compassion fatigue and burn out in nursing

Background: Compassionate care is essential for better clinical and patient outcomes, but during healthcare provision it can be compromised by several factors. This study evaluates factors affecting compassion satisfaction, compassion fatigue and burnout in nursing. Methods: Literature search in electronic databases was followed by data extraction, conversion, and meta-analyses under random effect model. Correlation coefficients (r) reported by individual studies were first converted to z-scores for meta-analyses and the overall effect sizes were then back-transformed into r. Results: Eleven studies (4054 respondents; 64.34 [95% confidence interval: 38.82, 89.86] % response rate; age 39.81 [31.36, 48.27] years; 87.11 [79.48, 94.73] % females) were used for meta-analysis. There was a strong positive correlation between compassion fatigue and burnout (r = 0.59), whereas compassion satisfaction had weak negative correlation with compassion fatigue (r = −0.226) but moderate with burnout (r = −0.446). Stress and negative affect were moderately positively associated with compassion fatigue (r = 0.405) but weakly correlated with burnout (r = 0.119). Positive affect and personal/social factors had weak inverse relationship with burnout (r = −0.197). Positive affect also had a moderately positive relationship with compassion satisfaction (r = 0.396). Demographic or professional factors were not significantly related to compassion satisfaction, compassion fatigue, or burnout. Conclusion: In nursing, a variety of stressful factors and negative affect promote compassion fatigue and burnout whereas positive affect is helpful in achieving compassion satisfaction.
Number 12 / 25 Rolie-Poly fluid flowing through constrictions : Two distinct instabilities by

Elastic instabilities of entangled polymer melts are common in industrial processes but the physics responsible is not well understood. We present a numerical linear stability study of a molecular based constitutive model which grants us physical insight into the underlying mechanics involved. Two constriction flows are considered one shear dominated, the other extension dominated and two distinct instabilities are found. The influence of the molecular structure and the behaviour of the polymer dynamics are investigated and in both cases chain relaxation and orientation play a crucial role. This suggests a molecular-based physical interpretation of the underlying mechanisms responsible for flow instabilities.
Assessing the ability of the Drug-Associated Risk Tool (DART) questionnaire to stratify hospitalised older patients according to their risk of drug-related problems: a cross-sectional validation study

Objectives The Drug-Associated Risk Tool (DART) has been developed as a self-administered questionnaire for patients with the aim of stratifying patients according to their risk of drug-related problems (DRPs). We aimed to validate the ability of the questionnaire to distinguish between hospitalised patients showing lower and higher numbers of DRPs. Design Cross-sectional study assessing the questionnaire’s concurrent criterion validity. Setting Five geriatric and the associated physical and neurological rehabilitation wards of a Swiss regional secondary care hospital with 617 beds. Participants We recruited 110 patients from a total of 437 admissions. Exclusion criteria were insufficient knowledge in spoken or written German, medical conditions preventing meaningful conversations and already receiving pharmacy services. Interventions Comprehensive pharmacist-led clinical medication reviews were performed, including patient interviews, to identify potential and manifest DRPs. A cluster analysis was conducted to assess the discriminatory potential of the DART to group patients according to number (low and high) of identified DRPs. A subsequent discriminatory function analysis was performed to reduce the number of items. We determined which DART items may be used to trigger what type of medication review. Results Recruited patients had a median age of 79 years and were prescribed a median of 11 drugs. Patients with a median DART score of 10 and a median of 3 DRPs represented one cluster, whereas patients with a median DART score of 15 and a median of 8 DRPs represented another cluster. Discriminatory function analysis reduced the questionnaire to five items with a moderate to strong correlation with the number of DRPs per patient (Spearman’s rank correlation ρ=0.44). Additional items were associated with patients benefiting from interviews. Conclusions As a self-administered questionnaire for patients, the DART may be used to stratify hospitalised non-acute older patients in groups of having low and high likelihood of DRPs. The analyses showed that a short form of the DART can be used instead of the full tool to identify older inpatients at risk for DRPs. Additional eight items from the DART may be used to initiate additional clinical pharmacy services. The linkage between certain DART questions and type of medication review enables pharmacist resource allocation.
Clients, Empathy, and Compassion: Introducing First-Year Students to the 'Heart' of Lawyering

In this piece I explore the need for instruction and experience with the "heart" of law practice within the first year of law school. According to the report on legal education prepared by the Carnegie Foundation, the two major limitations in American legal education are 1) a lack of attention to practical education, including a marked lack of understanding client problems, and 2) failure to support development of ethical and social skills. With the release of this report it is likely that law school faculties throughout the United States will be looking at their curricula to see how to better fill these gaps and better prepare the students to be practicing lawyers rather than legal scholars. This presents an important opportunity for law faculty, many of whom already recognize that legal education means more than teaching students the complexities of legal analysis, often referred to as how to "think like a lawyer," but also how to communicate, work with people, and advocate for their clients like lawyers do. But, what they may not recognize is that they are also perfectly suited to teach the "heart" of lawyering. Whether it is helping students to see their clients as real people with real problems or helping students to realize that empathy and compassion are critical for successful law practice, the first year of law school is the ideal place to begin to fill this gap in legal education.
The effect of Darapladib as a lipoprotein-associated phospholipase A2 inhibitor to interleukin-1β and interleukin-6 on diabetes mellitus Sprague-Dawley rat model: A new therapeutic target of diabetes mellitus to decrease cardiovascular risk

Cardiovascular disease currently listed as the main cause of death in the world. Ischemic heart disease and stroke are on the top list of 10 causes death worldwide and have remained the leading causes of death globally in the past 15 years. [1,2] A great majority of death related to cardiovascular events occur due to atherosclerotic and its acute complications, mainly based on plaque disruption. Inflammation is the most important mechanism of plaque disruption, and it is important to understand its molecular mechanism. [3-5]
FAST TRACK PAPER: Observational analysis of correlations between aftershock productivities and regional conditions in the context of a damage rheology model

A conductive polymer composition which has a resistivity at 20 DEG C. of at most 1.0 ohm-cm and a PTC anomaly of at least 104 contains at most 64% by volume of a crystalline polymeric component and at least 36% by volume of a particulate conductive filler. A preferred conductive filler is carbon black having a DBP number of 60 to 120 cm3/100 g. Compositions of the invention, as well as other conductive polymer compositions are preferably prepared by a method in which the polymeric component and the filler are blended in a first step at a temperature greater than the melting temperature of the polymer, the mixture is then cooled, and the mixture is then mixed in a second step. The resulting composition has a PTC anomaly that is at least 1.2 times the PTC anomaly of the first mixture.
Modelling Specifications for Competence

Modelling competences is an integral part of many e-Learning and Human Resource (HR) related activities. HR departments use competence descriptions to define requirements needed for performing specific tasks or jobs. In distributed e-learning curricula or training programmes need to describe prerequisites that must be fulfilled before joining and the competences that will be acquired after successful completion. This paper provides an overview of existing modelling specifications and describes our modelling approach for competencies, the structure of the Competency Catalogue and gives examples on how a competency can be modelled. Finally, section 5 concludes this paper with a summary and an outlook on future work
Worlds Apart – Ontological Knowledge in Question Answering for Patients

We present ESICT, a hybrid question-answering system building on formalized knowledge from a medical ontology (SNOMED CT) as well as text-to-text generation in the form of document summarization and question generation. The independent subsystems are queried in parallel and compete for delivering the best answer. The use of an ontology gives the patient access to information typically not found in other sources, but also exposes a gap between everyday language and the specialized terms and conceptualizations of health professionals. In this paper we describe the ESICT system and discuss for each strategy how well it deals with this gap.
Probing the phase transition of aqueous solutions of linear low molecular weight poly(N-isopropylacrylamide) by dielectric spectroscopy

Aqueous solutions of linear poly(N-isopropylacrylamide) (pNIPAM) with different polymer concentrations are investigated using dielectric spectroscopy in a frequency range of 10−1 Hz to 106 Hz at temperatures from 15 °C to 50 °C. The phase transition of pNIPAM is monitored by both the temperature (T) and the frequency (f) dependence of the conductivity spectra σ*(f, T). First, the T-dependence of the DC conductivity σ′DC is investigated and the phase transition (“coil-to-globule” transition) at the lower critical solution temperature (LCST) of pNIPAM is deduced by a change in the T-dependence of σ′DC. The observed hysteresis between heating and cooling runs is discussed in detail in dependence on both the polymer concentration and the rate. Second, for the first time a pronounced f-dependence of the real part of conductivity σ′ is observed at temperatures above the LCST whereas at temperatures below the LCST the conductivity spectra are more or less similar to that of water (frequency independent). This f-dependence of σ′ is assigned to the formation of a kind of soft particle (“globular structure”) at the LCST which is more or less impermeable to water and ions therefore giving rise to Maxwell–Wagner–Sillars (MWS) polarization effects (blocking of charges at the soft particle). The dependence on the concentration is studied in detail.