Miracle-dz/UniFAR-FTUs huggingface dataset:
Nonnegative Restricted Boltzmann Machines for Parts-based Representations Discovery and Predictive Model Stabilization

The success of any machine learning system depends critically on effective representations of data. In many cases, it is desirable that a representation scheme uncovers the parts-based, additive nature of the data. Of current representation learning schemes, restricted Boltzmann machines (RBMs) have proved to be highly effective in unsupervised settings. However, when it comes to parts-based discovery, RBMs do not usually produce satisfactory results. We enhance such capacity of RBMs by introducing nonnegativity into the model weights, resulting in a variant called nonnegative restricted Boltzmann machine (NRBM). The NRBM produces not only controllable decomposition of data into interpretable parts but also offers a way to estimate the intrinsic nonlinear dimensionality of data, and helps to stabilize linear predictive models. We demonstrate the capacity of our model on applications such as handwritten digit recognition, face recognition, document classification and patient readmission prognosis. The decomposition quality on images is comparable with or better than what produced by the nonnegative matrix factorization (NMF), and the thematic features uncovered from text are qualitatively interpretable in a similar manner to that of the latent Dirichlet allocation (LDA). The stability performance of feature selection on medical data is better than RBM and competitive with NMF. The learned features, when used for classification, are more discriminative than those discovered by both NMF and LDA and comparable with those by RBM.
Dry-etched silicon-on-insulator waveguides with low propagation and fiber-coupling losses

Optical rib waveguides with various widths and heights were fabricated on silicon-on-insulator (SOI) substrates. Silicon etching was based on dry etching with inductively coupled plasma (ICP)-type reactive ion etcher. The etching process was developed to ensure low optical losses. Propagation loss of 0.13/spl plusmn/0.02 dB/cm was measured for the fundamental mode at the wavelength of 1550 nm in a curved 114-cm-long waveguide. The reflection losses were suppressed by applying atomic layer deposition (ALD) in the growth of antireflection coatings (ARCs).
The ACA 10 Ca 2 1-ATPase Regulates Adult Vegetative Development and Inflorescence Architecture in Arabidopsis 1 [ W ] [ OA ]

The Arabidopsis (Arabidopsis thaliana) compact inflorescence (cif) genotype causes altered adult vegetative development and a reduction in elongation of inflorescence internodes resulting in formation of floral clusters. The cif trait requires both a recessive mutation, cif1, and the activity of a naturally occurring dominant allele of an unlinked gene, CIF2. We show here that the pseudoverticillata mutation is allelic with cif1 and that the product of the CIF1 gene is ACA10, a member of the large family of P-type Ca-ATPases found in higher plants. T-DNA insertion mutations in ACA10, but not in the two other Arabidopsis plasma membrane Ca-ATPase-encoding genes, ACA8 and ACA9, cause a cif phenotype when combined with the dominant CIF2 modifier allele. Therefore, ACA10 has a unique function in regulating adult phase growth and inflorescence development. The wild-type ACA8 and ACA10 mRNAs are present at similar levels, and the two promoter-b-glucuronidase fusion transgenes show very similar expression patterns. Moreover, transformation of the cif mutant with an extra copy of the ACA8 gene, which causes overexpression of the ACA8 transcript, can complement the cif phenotype. This suggests that these two Ca pump genes have distinct but related activities and that their differential functions can be altered by relatively small changes in their patterns or levels of expression. The correspondence between cif1 and mutations in ACA10 establishes a genetic link between calcium transport, vegetative phase change, and inflorescence architecture.
Analysis of Ultra-Thin and Flexible Current Transformer Based on JA Hysteresis Model

This paper describes the design, fabrication, and analysis of an ultra-thin and highly flexible current sensing transformer. The transformer windings are printed on flexible polyimide substrate layers with a magnetic foil sandwiched in between. The fabricated transformer can wrap around any electrical cable for current sensing purpose. The design of the transformer adopts a circuit model that includes the nonlinearity of the magnetic core based on the Jiles–Atherton hysteresis model, which is validated experimentally.
Serum monoclonal immunoglobulins in childhood

Of 18 children with monoclonal immunoglobulins in their sera, 13 had a primary or secondary immunodeficiency. The monoclonal immunoglobulin belonged to each of the three main Ig classes, and in 3 children multiple monoclonal components were detected. The level of the monoclonal component exceeded 0·5 g/100 ml in 7 cases. The monoclonal immunoglobulin disappeared spontaneously in 9 children. The significance of this homogeneous component and the importance of the underlying immunodeficiency are outlined.
Induction of Apoptosis by Sindbis Virus Occurs at Cell Entry and Does Not Require Virus Replication

ABSTRACT Sindbis virus (SV) is an alphavirus that causes encephalitis in mice and can lead to the apoptotic death of infected cells. To determine the step in virus replication during which apoptosis is triggered, we used UV-inactivated SV, chemicals that block virus fusion or protein synthesis, and cells that do and do not express heparan sulfate, the initial binding molecule for SV infection of many cells. In initial experiments, UV-inactivated neuroadapted SV (NSV) induced apoptosis in Chinese hamster ovary (CHO) cells lacking heparan sulfate in the presence of cycloheximide. When fusion of prebound UV-inactivated NSV was rapidly induced at the plasma membrane by exposure to acidic pH, apoptosis was induced in CHO cells with or without heparan sulfate in the presence or absence of cycloheximide in a virus dose-dependent manner. In N18 neuroblastoma cells, the relative virulence of the virus strain was an important determinant of apoptosis induced by UV-inactivated SV. Treatment of N18 cells with monensin to prevent endosomal acidification an hour before, but not 2 h after, exposure to live NSV blocked the induction of cell death, as did treatment with NH4Cl or bafilomycin A1. These studies indicate that SV can induce apoptosis at the time of fusion with the cell membrane and that virus replication is not required.
Ontogenetic thermal tolerance and performance of ectotherms at variable temperatures

Early experience and environmental conditions during ontogeny may affect organismal structure, physiology and fitness. Here, we assessed the effect of developmental acclimation to environmental thermal variability on walking speed in Drosophila melanogaster adults. Our results showed a shift in the performance curve to the right. Thus, upper and lower thermal limits exhibited developmental plasticity. Additionally, in constant and variable climatic scenarios, flies shifted to the right the optimum temperature but the maximum performance decreased only in flies reared on high temperatures and high thermal variability. Overall, we showed that environmental cues during ontogeny might help to construct phenotypic variation, which supports the hypothesis of ontogenetic dependence of thermal tolerances.
Power flow management strategies for a local DC Distribution System of More Electric Aircraft

The local DC Power Distribution System of More Electric Aircraft has to be able to sustain bidirectional power flow to and from electromechanical devices. Because the mechanical source (Turbine Engine) is unidirectional, some storage and dissipation systems are necessary to store or/and dissipate the returned energy to maintain the DC bus voltage to the reference value. Different power management strategies are proposed and compared. The development of experimental test benches is necessary to validate these strategies. In this paper, we present a 3kW test bench, emulating a unidirectional source that supplies a bidirectional load with the help of a hybrid system using supercapacitors and a dissipation system. The experimental validation of the power management strategies is presented in this paper too.
A Comparison of Ziprasidone and Risperidone in the Long-Term Treatment of Schizophrenia: A 44-Week, Double-Blind, Continuation Study

Objective: This randomized, double-blind, multicentre extension study compared the efficacy, tolerability, and safety of ziprasidone and risperidone for schizophrenia or schizoaffective disorder. Methods: Patients who had responded to treatment for an acute exacerbation of illness in an 8–week study received ziprasidone, 80 to 160 mg/day (n = 62), or risperidone, 6 to 10 mg/day (n = 77), for up to 44 additional weeks. Primary efficacy variables included changes in Positive and Negative Syndrome Scale (PANSS) total score and Clinical Global Impression Severity (CGI-S) score. Tolerability and safety assessments included movement disorders, adverse events, study discontinuation rates, and weight and metabolic parameters. Results: Both the ziprasidone and risperidone groups showed statistical improvement from baseline in PANSS and CGI-S scores at study end point with no significant differences between treatment groups. More risperidone-treated patients completed the study (41.6%) than ziprasidone-treated patients (33.9%), but the difference was not statistically significant. Ziprasidone-treated patients who completed the study showed greater improvement in depressive symptoms assessed by Montgomery and Asberg Depression Rating Scale than risperidone-treated patients (P < 0.05). Ziprasidone was associated with a more favourable effect on extrapyramidal symptom (EPS) measures and prolactin as well as less weight gain than risperidone. Median dosages were ziprasidone 120 mg/day and risperidone 8 mg/day. Conclusions: Ziprasidone and risperidone demonstrated similar efficacy during long-term treatment of patients with schizophrenia or schizoaffective disorder. While more subjects on risperidone completed the extension study, ziprasidone was associated with fewer adverse effects on weight, EPS measures, and prolactin than risperidone.
Transition from locking to pulling in injection-locked dividers

A comprehensive methodology of analysis of Injection-Locked Frequency Dividers (ILFDs) allows us not only to estimate the locking range, the amplitude and the phase of the locked oscillations and their stability, but also to investigate the transition from the locking mode to the pulling mode, that happens in proximity of the boundaries of the locking region. We highlight that there exists a border region where the two modes of operation can coexist and the occurrence of one mode, or the other, depends only on the initial conditions. Numerical simulations confirm analytical predictions.
A polynomial chaos based Bayesian approach for on-line parameter estimation and control

We propose a method for on-line parameter estimation and control of dynamical systems with uncertainties. The unknown initial conditions and parameters of the system are estimated within a Bayesian framework as the data are provided sequentially while the underlying unknown state of the system is estimated through its polynomial chaos expansion. The state dependent feedback control is computed by the minimization of the expectation of an appropriate cost function. This work is motivated by the biological problem of controlling the glucose-insulin system in mice.
The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin.

Utrophin is a close homologue of dystrophin, the protein defective in Duchenne muscular dystrophy. Like dystrophin, it is composed of three regions: an N-terminal region that binds actin filaments, a large central region with triple coiled-coil repeats, and a C-terminal region that interacts with components in the dystroglycan protein complex at the plasma membrane. The N-terminal actin-binding region consists of two calponin homology domains and is related to the actin-binding domains of a superfamily of proteins including alpha-actinin, spectrin and fimbrin. Here, we present the 2.0 A structure of the second calponin homology domain of utrophin solved by X-ray crystallography, and compare it to the other calponin homology domains previously determined from spectrin and fimbrin.
Selected Aspects of Mediterranean Diet and Cancer Risk

European Mediterranean populations have a high life expectancy. Several aspects of their diet are considered favorable on health. We considered the role of various aspects of the Mediterranean diet on cancer risk in a series of Italian case-control studies including about 10,000 cases of cancer at 13 different sites and over 17,000 controls. For most epithelial cancers, the risk decreased with increasing vegetable consumption. Allium vegetables were also favorably related to cancer risk. Fruit intake was inversely associated with digestive tract and laryngeal cancers. For digestive tract cancers, the population attributable risks for low intake of vegetables and fruit ranged between 15% and 40%. Olive oil and unsaturated fats, which are typical aspects of the Mediterranean diet, were inversely related to the risk of several cancers, particularly of the upper aerodigestive tract. Whole grain food (and hence possibly fiber) intake was also related to reduced risk of various cancers. In contrast, refined grains and, consequently, glycemic load and index were associated to increased risks. Several micronutrients and food components (including folate, flavonoids, and carotenoids) showed inverse relations with cancer risk, but the main component(s) responsible for the favorable effect of a diet rich in vegetables and fruit remain undefined.
Achieving the perfect secrecy for the Gaussian wiretap channel with side information

This paper extends the Gaussian wiretap channel (GWC) model introduced by Leung-Yan-Cheong and Hellman (1978) to the Gaussian wiretap channel with side information (GWCSI) by adding an additive white Gaussian interference in the main channel, which is available to the encoder in advance. It can also be looked at as an extension of the dirty-paper channel (DPC) introduced by Costa (1983). We propose a coding strategy achieving perfect secrecy for the extended channel, called Gaussian wiretap channel with side information. The corresponding achievable rates with asymptotic perfect secrecy are obtained and compared to known upper and lower bounds.
Correlation-Immune Functions over Finite Fields

We give a series of constructions of correlation-immune function over finite fields. We prove that F/sub 2/ and F/sub 3/ are the only finite fields F/sub q/ with the property that every (n-1)th correlation-immune function in n>2 variables over F/sub q/ is linear. We also show that by choosing larger finite fields one can alleviate the tradeoff between the length of the linear equivalent and the order of correlation immunity. This is useful for the design of various cryptosystems.
The Neonatal FcR-Mediated Presentation of Immune-Complexed Antigen Is Associated with Endosomal and Phagosomal pH and Antigen Stability in Macrophages and Dendritic Cells

The FcγRs found on macrophages (Mϕs) and dendritic cells (DCs) efficiently facilitate the presentation or cross-presentation of immune-complexed Ags to T cells. We found that the MHC class I-related neonatal FcR for IgG (FcRn) in both Mϕs and DCs failed to have a strong effect on the cross-presentation of immune complex (IC) OVA Ag to CD8+ T cells. Interestingly, endosomal FcRn enhanced the presentation of the monomeric OVA-IC to CD4+ T cells robustly, whereas FcRn in phagosomes exerted distinctive effects on Ag presentation between Mϕs and DCs. The presentation of phagocytosed OVA-ICs to CD4+ T cells was considerably enhanced on wild-type versus FcRn-deficient Mϕs, but was not affected in FcRn-deficient DCs. This functional discrepancy was associated with the dependence of IgG–FcRn binding in an acidic pH. Following phagocytosis, the phagosomal pH dropped rapidly to <6.5 in Mϕs but remained in the neutral range in DCs. This disparity in pH determined the rate of degradation of phagocytosed ICs. Thus, our findings reveal that FcRn expression has a different effect on Ag processing and presentation of ICs to CD4+ T cells in the endosomal versus phagosomal compartments of Mϕs versus DCs.
Cancer-Related Insomnia

Insomnia increases cancer symptom burden and impairs quality of life. The lack of standard definitions and treatment guidelines makes management difficult. Insomnia is common in most cancers but appears particularly so in lung, breast, and head and neck tumors. Older women seem most susceptible. Insomnia not only affects patients with cancer but also caregivers and families. Systematic screening is important. Few validated assessment scales are available. Nonpharmacologic therapies like cognitive behavioral therapy may help. New nonbenzodiazepine hypnotics may have some therapeutic advantages over older agents. Management of associated or contributory symptoms like fatigue, pain, and hot flashes with appropriate symptom-specific agents is important. Successful management may have a significant positive impact on global quality of life.
Large-Scale Real-Time Semantic Processing Framework for Internet of Things

Nowadays, the advanced sensor technology with cloud computing and big data is generating large-scale heterogeneous and real-time IOT (Internet of Things) data. To make full use of the data, development and deploy of ubiquitous IOT-based applications in various aspects of our daily life are quite urgent. However, the characteristics of IOT sensor data, including heterogeneity, variety, volume, and real time, bring many challenges to effectively process the sensor data. The Semantic Web technologies are viewed as a key for the development of IOT. While most of the existing efforts are mainly focused on the modeling, annotation, and representation of IOT data, there has been little work focusing on the background processing of large-scale streaming IOT data. In the paper, we present a large-scale real-time semantic processing framework and implement an elastic distributed streaming engine for IOT applications. The proposed engine efficiently captures and models different scenarios for all kinds of IOT applications based on popular distributed computing platform SPARK. Based on the engine, a typical use case on home environment monitoring is given to illustrate the efficiency of our engine. The results show that our system can scale for large number of sensor streams with different types of IOT applications.
Investigating the Role of ventral veins lacking in the Endocrine Regulation of Metamorphic Timing

6 Introduction 7 Regulation of endocrinology in insect development 7 The roles of critical weight and threshold size on the onset of metamorphosis 9 Critical weight 9 Threshold size 10 Juvenile hormone and prothoracicotropic hormone 11 Halloween genes and their role in the regulation of ecdysone biosynthesis 12 The significance of Vvl, a POU transcription factor 13 Oenocytes as a site of vvl expression 15 Objectives and hypothesis 15 Gene silencing using RNA interference (RNAi) 16 Tribolium castaneum and Manduca sexta as model organisms 17 Materials and Methods 19 Animal husbandry 19 Isolating RNA and synthesizing complementary DNA (cDNA) 19 Polymerase chain reaction (PCR) and gel electrophoresis 20 Cloning using TOPO TA and synthesizing double-stranded RNA (dsRNA) 21 Injecting double-stranded RNA (dsRNA) into Tribolium and treatment of 20E 22 Quantitative RT-PCR 22 Manduca body dissections 24 Results 25 vvl expression in Tribolium 25 vvl-knockdown results in reduction of jhamt3 expression 27 vvl-knockdown results in reduction of kr-h1 expression 29 vvl-knockdown larvae exhibit decreased ecdysone-response gene expression 31 vvl-knockdown influences the expression of certain Halloween genes 33 Effect of starvation on vvl expression in Manduca 40
Churg-Strauss syndrome associated with montelukast

Churg-Strauss syndrome (CSS) has recently been reported in patients with asthma receiving leukotriene receptor antagonists (LTRAs). In this paper a case of CSS after treatment with montelukast is described. As in other LTRA treated cases, prior withdrawal of maintenance oral steroid may have unmasked a previously occult CSS in the patient, but a dramatic improvement in his eosinophilia after withdrawing montelukast implied that the drug also had a direct effect in activating this condition.
Efficacies of Novel N-Halamine Disinfectants against Salmonella and Pseudomonas Species

Six novel N-halamine compounds of potential importance as disinfectants to the food-processing industry were tested against Salmonella enteritidis, Salmonella gallinarum, Salmonella typhimurium, and Pseudomonas fluorescens in aqueous solution. Inactivation times for 106-fold reductions were determined as a function of water quality at pH 6.5 and 25°C. Phenol coefficients for the efficacies of the compounds against S. enteritidis have been reported also. When both stability and efficacy data are considered, as well as cost of production, two compounds, 1,3-dichloro-2,2,5,5-tetramethylimidazolidin-4-one and 1-chloro-2,2,5,5-tetramethylimidazolidin-4-one, offer the greatest potential as biocides for the food-processing industry.
Density-Gradient Centrifugation: Non-Ideal Sedimentation and the Interaction of Major and Minor Components

A small amount of southern bean mosaic virus was contained in a narrow zone after density-gradient centrifugation, but in a much wider zone after centrifugation with a large amount of a second virus. Zone-spreading of a major component by non-ideal sedimentation in density-gradient centrifugation can cause zone spreading of a minor component that the major component overlaps.
Different effective dose conversion coefficients for monoenergetic neutron fluence from 10-9 MeV to 20 MeV – A methodological comparative study

Calculations are presented of the effective doses per unit neutron fluence according to the ICRP publications 60 and 103. Monte Carlo N-Particle (MCNPX) code was used for six geometrical conditions of irradiation (Anterior-Posterior, Posterior-Anterior, Left-Lateral, Right-Lateral, Rotation and Isotropic) on Oak Ridge National Laboratory (ORNL) modified mathematical adult phantoms for monoenergetic neutrons from 10-9 MeV to 20 MeV. The conversion coefficients were compared with the results of an analytical phantom (Medical Internal Radiation Dose (MIRD-5)) and some voxel model (ICRP/ICRU Reference Voxel Phantom (ICRP/ICRU RVP), HANAKO, TARO and Visible Human Project (VIPMAN)). From these comparisons, one can conclude that large discrepancies between data sets appear when wR and different sizes of the phantoms have been used for calculations. Furthermore, the differences in applied Monte Carlo codes or simulated body models could make some discrepancies less than 15%.
Une nouvelle méthode graphique pour interroger et vérifier des diagrammes de classes UML

Résumé. UML est le langage graphique de référence dans l’industrie pour la modélisation objet. Cependant UML reste un langage, et ne fournit aucun moyen de vérification ou d’interrogation de ses schémas. Il existe aujourd’hui des outils de vérification, mais ils se comportent comme des bôıtes noires où l’utilisateur ne peut accéder. Nous proposons une méthode graphique de vérification et d’interrogation de diagrammes de classes UML. L’aspect intuitif et dessinable de notre méthode offre à l’utilisateur la possibilité d’interroger le contenu de diagrammes de classes, ainsi que de définir et d’adapter ses propres critères de vérification. Le modèle calculatoire de notre approche est celui des graphes conceptuels.