Miracle-dz/UniFAR-FTUs huggingface dataset:
TINGKAT KEGANASAN KANKER SERVIKS PASIEN PRA-RADIASI MELALUI PEMERIKSAAN AgNORs, MIB-1 DAN Cas- 3

Kanker serviks sering ditemukan di negara berkembang. Pengobatan kanker melalui radioterapi untuk mengetahui tingkat proliferasi dan mengurangi tingkat keganasan. Biomarker proliferasi dan apoptosis berupa AgNORs, MIB-1, dan Caspase 3. Namun belum dijelaskan mengenai korelasi ketiga biomarker dalam kaitannya dengan proliferasi dan apoptosis pada sel kanker serviks. Tujuan penelitian untuk mengetahui korelasi antara AgNORs, MIB-1, dan apoptosis pada kanker serviks. Penelitian observasional laboratoris menggunakan metode pewarnaan dengan menekankan kontras warna antara sitoplasma dan inti sel. Objek berupa sediaan mikroskopis dari 30 biopsi pasien kanker serviks. Pengambilan data dengan metode crocker dan blind manner. Analisis data menggunakan uji korelasi, dari ju mlah 21 pasien yang diamati menunjukkan. AgNORs dan MIB-1 memiliki angka relatif tinggi. Angka yang diperoleh ini berbanding terbalik dengan apoptosis yang relatif rendah. Korelasi antara AgNORs dengan MIB-1 menunjukkan r= 0,33 dan p= 0,15. AgNORs dengan apoptosis memiliki korelasi negatif yakni, r=-0,08 dan p= 0,73. MIB-1 dengan apoptosis memiliki korelasi negatif pula r= -0,18 dan p= 0,43. Kesimpulannya korelasi AgNORs dengan apoptosis memiliki kecenderungan lebih baik dari pada MIB-1 dengan apoptosis. Cervical cancer is often found in the developing countries. The treatment of cancer through radiotherapy was performed to determine the proliferation level and to reduce the malignancy level of cancer. The proliferation and apoptotic biomarkers were AgNORs, MIB-1, and Cas- 3. However, the correlation between the three biomarkers in relation to the proliferation and apoptosis in cervical cancer cells was not clear. The purpose of the study was to determine the correlation between AgNORs, MIB-1 and apoptosis in cervical cancer. This study was an observational research laboratory using a staining method to emphasize the color contrast between the cytoplasm and the nucleus of the cells. The microscopic preparations of the 30 patients with cervical cancer biopsies had been used as the study objects. Data was collected using the Crocker and Blind method and was then analyzed using correlation test. Data from 21 patients with AgNORs and MIB-1 showed a relatively high value. The figure obtained was inverse proportionally to the relatively low apoptotic value. The correlation between AgNORs and MIB-1 showed r = 0.33 and p = 0.15. There was negative correlation between AgNORs and apoptosis at r = -0.08 and p = 0.73. Meanwhile, between MIB-1 and apoptosis has also a negative correlation at r = -0.18 and p = 0.43. It was concluded that the correlation between AgNORs and apoptosis tended to be better than the MIB-1 and apoptosis.
Examining health information systems success factors in Uganda’s healthcare system

Health Information Systems offer several benefits towards healthcare service delivery in Uganda including easy record keeping, enhancing communication, performing simple calculations, supporting decision making, gaining competitive advantage, better management of chronic diseases, faster retrieval of records, improving process flow and increasing productivity. However, the benefits mentioned have been hindered by failure of Health Information System. The success factors Health Information System in Ugandan healthcare system are largely unknown. The effect of these failures is most felt in Small and Medium Healthcare Enterprises who have limited resources and semi-skilled employees. This study determines success factors for Health Information Systems in Small and Medium Healthcare Enterprises in a developing country context like Uganda. The findings of the study therefore aid in understanding the key issues that lead to the success of Health Information Systems in developing countries, Uganda in particular. The study targeted staff of Small and Medium Healthcare Enterprises including doctors, nurses, administrators and laboratory attendants. A sample of 274 was taken from 274 health units but only 202 questionnaires were considered for analysis after data cleaning. Data were analyzed using Convergent and Discriminant Validity, Rotated Component Matrix tables, Communality and Regression analysis. The findings indicate that management support, user involvement, resource supply, and education and training are the most important success factors for Health Information Systems success. Principal component analysis obtained show that all items on the listed variables had communalities above the significant level of 0.4 implying that all items exhibited sufficient loadings. This therefore implies that each of the items correlates highly with all other items and can at least easily load onto one of the factors. Further, multiple correlation coefficient R=0.717 obtained implies that there is a strong relationship between the multiple independent factors and the dependent variable.
EFFECTIVENESS OF SCREENING EXAMINATIONS TO DETECT UNRECOGNIZED EXERCISE-INDUCED BRONCHOCONSTRICTION

Hallstrand TS, Curtis JR, Koepsell TD, et al. J Pediatr. 2002;141:343–349 To determine if physician-administered physical examination and screening questionnaire accurately detects exercise-induced bronchoconstriction (EIB) in adolescent athletes. Two hundred fifty-six adolescents participating in organized sports from 3 suburban high schools. The number screened positive from the examination and questionnaire was compared with EIB diagnosed by the …
Nanoscale antigen organization regulates binding to specific B-cells and B-cell activation

The successes of vaccines in modern medicine diminished the morbidity and mortality of many pathogenic infections. Yet, difficulties remain in improving the immunogenicity of modern subunit vaccines. In addition, isolation of antigen-specific memory B cells that would elucidate the long-term efficacy of vaccines beyond using antibody titers as surrogates has been challenging due to the lack of specific and sensitive detection reagent. We sought to improve the binding and activation of B cells by presenting antigens in a multivalent manner on the surface of liposomes. Motivated by structural requirements originally defined for haptens triggering T-cell-independent stimulation of B cells, we investigated how the mode of antigen presentation, antigen density, particle size, and lipid mobility influence B cell receptor (BCR) crosslinking by multivalent antigen-bearing liposomes, and found that BCR binding is not only a function of antigen density, but also the spacing of antigens on a nanoscaleeven for highly multivalent particles. We demonstrated high sensitivity in detecting antigen-specific B cells in vitro, as well as in detecting antigenspecific memory B cells in immunized mice. We first present a novel method of nanoclustering biotinylated antigens conjugated on liposomes with streptavidin, and examine the effect of nanoclustering on BCR binding and B cell response. The mere addition of streptavidin to otherwise 'unclustered' antigens displayed on liposomes increased binding of these particles to antigen-specific B-cells twofold and upregulated activation markers six fold while demonstrating a dose-sparing effect. A three-fold increase in the expression of the activation marker CD86 over soluble tetrameric antigen indicated that surface presentation on liposomes enhances the recognition of nanoclustered antigen by B cells. We then examined how nanoscale organization of antigens influences B cell responses for application to subunit vaccines, using well-defined peptide antigen multimers. Our experiments revealed that B cells bind to and respond to antigens in a valency-dependent manner, with a end-to-end distance spacing of approximately 11.8 nm required between antigens. In vivo immunization experiments demonstrated that higher antigen valencies elicited increased antigen titers and antibody avidity, as well as a responsive memory B cell population that proliferated more rapidly during secondary challenge, indicating a promising strategy for designing subunit vaccines of high immunogenicity.
Biomechanische Prinzipien in Diarthrosen und Synarthrosen - Teil I: Grundbegriffe bei Diarthrosen

: The incongruity of the articulating surfaces is one of the main constructional characteristics of human joints. Unfortunately, this has virtually been neglected in studying of the mechanism of joints. Only in incongruent articulating surfaces does the force locking, which is permanently produced by gravity and/or compressively acting muscular forces (muscular tonus), engender mechanically stable states of balance of the connected limbs. From the incongruity one can conclude that the dimeric link chain represents the most simple constructional element of the human joints. They are force locked, constrained gear systems composed by dimeric link chains. In this context the overlapped dimeric link chain deserves special attention since it is the only mechanically stable device in the presence of compressive forces. We present fundamental terms and characteristics of the gear mechanisms of human joints.
Functional Electrical Stimulation: Standing and Walking after Spinal Cord Injury

Introduction. Muscle Restrengthening and Patient Conditioning. Influence of Electrical Stimulation on Spas-ticity in Spinal Cord Injured Patients. Restoration of Standing. FES Ambulation Program in Incomplete SCI Patients. FES-Assisted Walk-ing in Complete SCI Patients. Index. 208 pp., 7x10, 1989, ISBN-0-8493-4529-4. Features:
Role of TNF‐α in ethanol‐induced hyperhomocysteinemia and murine alcoholic liver injury

We previously reported a link between ethanol‐induced elevation of homocysteine, endoplasmic reticulum (ER) stress, and alcoholic liver injury in the murine model of intragastric ethanol feeding. We studied the role of TNFα in this setting by using TNFR1 knockout mice (C57 BL/6). There was a 7.4‐fold increase of homocysteine in wild‐type and a 6‐fold increase in TNFR1 knockout mice with intragastric alcohol exposure for 4 weeks. Plasma TNFα increased in the wild‐type (18.4 ± 3.3 pg/mL vs. 8.4 ± 1.3 pg/mL (control)) and in the knockouts (12.9 ± 1.4 pg/mL vs. 7.2 ± 1.6 pg/mL (control)). Similar extent of fatty liver was observed in both types. Increased ALT was observed in both groups. Necroinflammatory foci were increased significantly in ethanol‐fed knockouts but not to the same extent as in the ethanol‐fed wild type. Increase of hepatic apoptosis and reduction of S‐adenosyl‐L‐methionine was detected in both types of animals fed ethanol. ER stress demonstrated by RT‐PCR of mRNA of selective ER stress markers GRP78, CHOP, and SREBP1 was increased equivalently in both types of mice. Betaine administration decreased ER stress in conjunction with attenuation of the elevated plasma homocysteine in both types of animals. Betaine increased hepatic S‐adenosyl‐L‐methionine by 28 fold in the knockouts and by 24‐fold in wild type. In conclusion, TNFα makes a moderate contribution to the ALT elevation, necroinflammation, apoptosis, a small contribution to the fatty liver and no contribution to hyperhomocysteinemia and ER stress in intragastric alcohol fed mice. (HEPATOLOGY 2004;40:442–451.)
PIONEERING PARADIGMS AND MAGNIFICENT MANIFESTOS -LEIGH VAN VALEN’S PRICELESS CONTRIBUTIONS TO EVOLUTIONARY BIOLOGY

Evolutionary biology lost a unique, broad, creative, and influential thinker when Leigh Van Valen1 passed away on October 16, 2010 in Chicago at the age of 75. He was Professor Emeritus of Ecology and Evolution at the University of Chicago and served on the Committees on Evolutionary Biology, Conceptual Foundations of Science and Genetics. Unwritten ideas still coursed through his ceaselessly active mind as he fought and lost his last battle against phylogenetically distant and diverse microbes. We are a multiflavored group who wants to honor this extraordinary thinker and teacher, and to bring broad attention to Leigh’s life’s work, much of which was ahead of his times. We reflect briefly on his work on mammal evolution, energy as an organizing principle in ecology and evolution, adaptation, evo–devo, homology and complexity, even though his “interests go beyond what this blurb indicates,” quoting directly from his homepage. Leigh’s niche in biology has been to open up new areas of research without attempting to provide final answers to the novel questions he identified. He synthesized empirical observations into a cohesive paradigm that often unified traditional disciplines.
Cincuenta años de uso clínico de la warfarina

La warfarina es el anticoagulante oral (AO) mas utilizado en la profilaxis a largo plazo de las complicaciones tromboembolicas que acompanan a diversas enfermedades. Sus indicaciones se han ampliado en los ultimos anos, a medida que son detectadas nuevas situaciones clinicas que predisponen a sufrir eventos tromboticos. Debido a sus caracteristicas especiales, tales como: dosis muy variable en cada individuo, estrecho margen entre la dosis adecuada y la inadecuada, interacciones con multiples farmacos, interferencia de su efecto por el alto consumo de vitamina K en la dieta y la posibilidad de que aparezcan complicaciones hemorragicas o recurrencia de la trombosis, el empleo de este medicamento requiere un estricto control de su dosificacion y una continua vigilancia, tanto desde el punto de vista clinico como de laboratorio. A pesar de sus numerosas desventajas y de tener mas de cincuenta anos de uso clinico, la warfarina no ha sido sustituida hasta la fecha, por el anti-coagulante oral de reciente aparicion. En el ano 1999, la warfarina llego a ocupar el decimo primer lugar entre los medicamentos de mayor consumo en el mundo.
HALLAZGOS RADIOLÓGICOS DEL SÍNDROME DE LADY WINDERMERE

Objetivos DocentesDescribir los hallazgos radiologicos del sindrome de Lady Windermere y realizar una breve revision de esta entidad. Revision del temaEl sindrome de Lady Windermere es un eponimo acunado por primera vez por Reich y Johnson en 1992 para describir 6 casos de mujeres inmunocompetentes sin enfermedad respiratoria previa, que presentaban infeccion por Myco-bacterium avium complex (MAC) a nivel del lobulo medio y/o la lingula [1]. La infeccion pulmonar por micobacterias ambientales (MA) viene adquiriendo cada vez mayor importancia epidemiologica tanto en personas sin enfermedad previa como en inmunodeprimidos. En Espana, MAC es globalmente considerada la segunda MA en prevalencia, por detras de Mycobacterium kansasii, aunque es la que mas afecta a la poblacion VIH positiva [2-8].
Individuelle Ressourcenausstattung und der Zugang zum Feld der Kunst

Kunst boomt. Medienberichten zufolge gehen immer mehr Menschen in Kunstmuseen, kaufen sich Kunstposter oder Originalgemalde (Rauterberg 2006). Ebenso konstatieren die Medien boomende Preise fur Kunstwerke; nahezu monatlich werden Rekordpreise von den grosen internationalen Auktionshausern gemeldet (Schreiber 2007), wobei mittlerweile selbst die Werke relativ junger Kunstler ausergewohnliche Preise bei Auktionen erzielen. Auf den ersten Blick ist damit ein widerspruchliches Bild der Entwicklung des zeitgenossischen Kunstfeldes gegeben: Auf der einen Seite scheinen sich immer mehr Menschen fur Kunst zu interessieren, was fur eine zunehmende Inklusion in dieses Feld spricht. Auf der anderen Seite werden die monetaren Preise fur Kunstwerke fur den Normalverdiener aber immer unerschwinglicher. Dieser Aufsatz will dieses medial verbreitete Bild korrigieren: Einerseits wird die These vertreten, dass das Interesse an Kunst faktisch sehr viel weniger inklusiv ist, als es haufig den Anschein hat, andererseits wird gezeigt, dass der Blick auf die Rekordauktionspreise weniger Kunstwerke eine zentrale Tatsache in den Hintergrund ruckt, dass namlich ein groser Teil der Kunstwerke fur recht niedrige Preise verkauft wird und daher fur ein nicht unerhebliches Bevolkerungssegment in den wohlhabenden OECDStaaten erschwinglicher ist, als man beim Blick auf die Rekordpreise vermuten konnte.
Artroplastia acromioclavicular na síndrome do impacto

Os autores apresentam o resultado de cinco pacientes adultos com `impacto acromioclavicular' tratados com a resseccao de 1cm distal da clavicula e liberacao do ligamento coracoacromial, segundo a tecnica de Watson. Todos os pacientes tinham exames radiologicos com alteracoes degenerativas, alem do exame clinico mostrando dor acromioclavicular com irradiacao para a face lateral do braco. O alivio da dor foi considerado bom em quatro dos pacientes, havendo melhora significativa do grau de abducao em todos os casos ao final do tratamento.
Aspects of Mono- and Multiple Dominant Follicle Development in the Human Ovary

s and presentations related to this thesis: Hohmann F.P., Laven J.S. E. , Eijkemans M.J.C. and Fauser B.C.J.M. (2000) Low dose exogenous FSH initiated during the early-, mid-, or late follicular phase: Effects on dominant follicle develop- ment. SGI Year 2000 Annual Meeting, March, 2000, Chicago, USA [J. Soc. Gynecol. Investig. (2000), 7, (suppl.no.1) 581]. Hohmann F.P., Laven J.S. E. , Eijkemans M.J.C. and Fauser B.C.J.M. (2000) Low dose exogenous fol- licle-stimulating hormone initiated during the early-, midor latefollicular phase in normo-ovu- latory women: Effects on single or multiple dominant follicle development. European Society for Human Reproduction and Embryology, ESHRE Annual Meeting 2000. Hohmann F.P. (2000) Eicellen op verzoek? VVAO (Vereniging voor Vrouwen met Academische Opleiding), November 4, 2000, Amsterdam. Hohmann F.P. (2000) Metformine: een antidiabeticum bij anovulatie? VVF (Vereniging voor Fertiliteitsartsen), November 29, 2000, Utrecht. 130 Pu b lic at io n s an d p re se n ta ti o n s Hohmann F.P., Laven J.S. E. , Eijkemans M.J.C. and Fauser B.C.J.M. (2001) Een lage dosering exogeen FSH toegediend tijdens de vroege, mid of laat folliculaire fase kan de ontwikkeling van meer- dere dominante follikels induceren. VFS (Vereniging voor Fertliteitsstudies), November 23, 2001,
Pruebas dinámicas en endocrinología: insuficiencia adrenal

Resumen: el diagnostico de insuficiencia adrenal se sospecha con los hallazgos clinicos en el paciente, pero solo se confirma con las pruebas de laboratorio. La insuficiencia adrenal primaria es causada por una lesion en la glandula adrenal, en tanto que la insuficiencia adrenal secundaria puede ser causada por enfermedad hipotalamica o hipofisaria, o como resultado de la supresion del eje hipotalamo-hipofisis-adrenal por esteroides. Los hallazgos clinicos de insuficiencia adrenal primaria incluyen fatiga, anorexia, diarrea, dolores osteomusculares e hiperpigmentacion, entre otros. Los hallazgos clinicos de la insuficiencia adrenal secundaria son similares; sin embargo, no se presenta hiperpigmentacion. Es comun que el clinico se enfrente a un paciente con sintomas inespecificos y no considere la posibilidad de un diagnostico de insuficiencia adrenal. Una prueba de tamizacion ideal debe ser de bajo costo, facil y segura; infortunadamente, hasta el momento, no se dispone de una prueba ideal para la insuficiencia adrenal. La determinacion del cortisol basal es una prueba que se utiliza comunmente para la tamizacion, que puede incluir (si es 18 µg/dL) una insuficiencia adrenal; sin embargo, la mayoria de los pacientes tendran un valor intermedio y por ello se haran necesarias las pruebas dinamicas. En el presente modulo se revisan las pruebas dinamicas en el estudio de la insuficiencia adrenal, incluyendo la prueba de tolerancia a la insulina, la prueba de estimulo con metirapona y la prueba de estimulo con cosintropina, como agentes inductores de la produccion de cortisol. Finalmente, se presenta un algoritmo para el estudio del paciente con sospecha de insuficiencia adrenal. Palabras clave: insuficiencia adrenal, cortisol, hormona adrenocorticotropica (ACTH), hormona liberadora de corticotropina (CRH), prueba de tolerancia a la insulina, prueba de estimulo con metirapona, prueba de estimulo con cosintropina. Arango-Toro C, Campuzano-Maya G, Latorre-Sierra G. Pruebas dinamicas en endocri
Physical activity and obesity in children: measurement, associations, and recommendations

Widespread increases in the prevalence of childhood obesity have raised the prospect of serious public health consequences in many countries. New Zealand is no exception; according to the most recent national estimates, approximately one in three children is overweight or obese. As a consequence, an understanding of the specific risk factors that predict this condition in children is becoming increasingly important. It is generally accepted that the promotion of physical activity is a key strategy for reducing the risk of childhood obesity. However, there is limited information describing physical activity and its relationship with body fatness in young New Zealanders. The overall aim of this thesis was to gain insight into the associations between excess fatness and physical activity in New Zealand children from a diverse range of socio-demographic groups. Three related studies were conducted to achieve this aim: a large descriptive survey of obesity and physical activity patterns in primary-aged children, and two preceding studies which develop the methodology for objective assessment of physical activity in this population. The first study provided the only validation data for the NL-2000 multiday memory (MDM) pedometer in children. In a sample of 85 participants aged 5-7 and 9-11 years, the NL-2000 offered similar accuracy and better precision than the widely used SW-200 pedometer (NL-2000: mean bias = -8.5 ± 13.3%; SW-200: mean bias = -8.6 ± 14.7%). The second study investigated reactivity to wearing pedometers over four 24-hour testing periods in 62 children aged 5-11 years. The sample was divided into two groups: one was given a full explanation of the function of the pedometer, while the other received no information prior to testing. The absence of significant differences in step counts between the first and last test periods indicated that there was no evidence of reactivity to this device for either preparation procedure. The central study presented in this thesis was the measurement of physical activity, body composition, and dietary patterns in 1,226 children aged 5-12 years, from which four chapters (4-7) were derived. The sample was ethnically diverse, with 46.8% European, 33.1% Polynesian, 15.9% Asian, and 4.1% from other ethnicities. Physical activity levels over three weekdays and two weekend days were assessed using NL-2000 pedometers. Percentage body fat (%BF) was determined using hand-to-foot bioelectrical impedance analysis with a prediction equation previously developed for
Post-Edit Generation terhadap Analisa Wisata dan Kuliner

Purwakarta merupakan salah satu daerah di Jawa Barat yang masyarakatnya tumbuh dan berkembang dari sejarah dan tradisi yang kental. Purwakarta memiliki banyak objek wisata yang dikelola oleh pemerintah maupun pihak swasta, selain objek wisata purwakarta juga dikenal dengan kulinernya yang sangat khas dengan cita rasa yang tradisional, tidak sedikit wisatawan purwakarta yang merasa bingung dalam memutuskan untuk mengunjungi tempat wisata yang cocok dikarenakan kurangnya informasi mengenai objek wisata maupun kuliner tersebut. Untuk itu dibutuhkan suatu sistem yang dapat membantu wisatawan untuk mendapatkan ringkasan informasi mengenai wisata dan kuliner terdekat serta memberikan rekomendasi sehingga peningkatan efisiensi dan efektifitas dalam pendistribusian informasi untuk calon wisatawan yang ingin berkunjung dan laporan hasil akhirnya terperinci mengenai kumpulan objek wisata dan kuliner yang ada di purwakarta sehingga memudahkan pengguna, yang mana inputanya berdasarkan deskripsi (Nama Tempat, Alamat, Fasilitas, Wahana) serta ulasan pengguna lainnya. Untuk itu penelitian ini menyajikan studi kasus Post-Edit Generation terhadap wisata dan kuliner di Purwakarta-Jawa Barat