Miracle-dz/UniFAR-FTUs huggingface dataset:
2DV RANS-VOF MODELLING OF DEPTHS AND VELOCITIES OF OVERTOPPING WAVES AT OVERWASHED DIKES

The purpose of this contribution is the representation of real wave overtopping over sea dikes with the Rans-Vof code (IH-2VOF) developed by the University of Cantabria. More specific objectives are: to identify the real capacity of the IH-2VOF model in the prediction of overflow and to determinate the accuracy of these predictions in order to provide designers with a generally applicable methodology to use the code. The model is validated against experimental tests conducted by Hughes at the U.S. Army Engineer Research and Development Center (ERDC). This analysis shows that the model tends to overestimate wave reflection and better results are obtained by introducing a porous layer around the structure as artificial way to reduce reflected wave energy.
Dark Matter Search Results from the CDMS II Experiment

News from the Dark Side? Dark matter is thought to represent 85% of all matter in the universe and to have been responsible for the formation of structure in the early universe, but its nature is still a mystery. Ahmed et al. (p. 1619, published online 11 February; see the Perspective by Lang) describe the results from the completed Cryogenic Dark Matter Search (CDMS II) experiment, which searched for dark matter in the form of weakly interacting massive particles (WIMP). Two candidate signals were observed, whereas only one background event was expected. The probability of having two or more events from the background would have been 23%. The results of this analysis cannot be interpreted with confidence as evidence for WIMP interactions, but, at the same time, neither event can be ruled out as representing signal. Details of possible, but unlikely, detection events produced by dark matter are reported. Astrophysical observations indicate that dark matter constitutes most of the mass in our universe, but its nature remains unknown. Over the past decade, the Cryogenic Dark Matter Search (CDMS II) experiment has provided world-leading sensitivity for the direct detection of weakly interacting massive particle (WIMP) dark matter. The final exposure of our low-temperature germanium particle detectors at the Soudan Underground Laboratory yielded two candidate events, with an expected background of 0.9 ± 0.2 events. This is not statistically significant evidence for a WIMP signal. The combined CDMS II data place the strongest constraints on the WIMP-nucleon spin-independent scattering cross section for a wide range of WIMP masses and exclude new parameter space in inelastic dark matter models.
A Utilization-Based Approach for Schedulability Analysis in Wireless Control Systems

Recent advancements in industrial Internet-of-Things (IoT), more specifically, the development of industrial wireless standards such as WirelessHART and ISA100, are paving the way for the fourth industrial revolution, Industry 4.0. These wireless standards specify highly reliable and real-time communications as key requirements in industrial wireless sensor-actuator networks. Schedulability analysis remains the cornerstone for analyzing the real-time performance of these networks. While it is well-explored in the domain of CPU scheduling, schedulability analysis for multi-hop wireless networks has seen little progress till date. Existing work mostly focuses on worst-case delay analysis that runs in pseudo-polynomial time, making it is less suitable under frequent network dynamics which are quite common in industrial IoT. To address this, in this paper, we develop a schedulability analysis based on utilization bound for multi-hop, multi-channel industrial wireless sensor-actuator networks. Because of its extremely low runtime overhead, utilization-based schedulability test is considered to be one of the highly efficient and effective schedulability analyses. However, no work has been done yet on utilization-based analysis for multi-hop wireless network. The key challenge for a utilization-based test for multi-hop wireless network arises from the fact that wireless network is subject to transmission conflict and network dynamics which are not present in CPU scheduling. We address this challenge by bridging the gap between wireless domain and CPU task scheduling. We have evaluated our result through simulations using TOSSIM that shows that our schedulability analysis is safe and effective in practice.
THE TOPOLOGY OF ISOPARAMETRIC SUBMANIFOLDS

It has been known since a famous paper of Bott and Samelson that, using Morse theory, the homology and cohomology of certain homogeneous spaces can be computed algorithmically from Dynkin diagram and multiplicity data. L. Conlon and J. Dadok noted that these spaces are the orbits of the isotropy representations of symmetric spaces. Recently the theory of isoparametric hypersurfaces has been generalized to a theory of isoparametric submanifolds of arbitrary codimension in Euclidean space, and these same orbits turn out to be exactly the homogeneous examples. Even the nonhomogeneous examples have associated to them Weyl groups with Dynkin diagrams marked with multiplicities. We extend and simplify the Bott-Samelson method to compute the homology and cohomology of isoparametric submanifolds from their marked Dynkin diagrams.
Which Firms Use Trademarks – And Why? Representative Firm-Level Evidence from Germany

Trademarking firms are more productive, generate higher profits, and have a better survival rate. Trademarking firms are in one word more successful, which might motivate non-trademarking firms to adopt a trademark strategy. But this seems not to be the case. The proportion of trademarking firms in the German business sector amounts to just 18%. This figure is quite low, given that nearly each firm has reputation to protect. But why has the vast majority of firms no registered trademarks? Using a representative sample of German firms, the present paper links certain firm characteristics to a firms' propensity to register trademarks. The empirical results point to circumstances under which trademarks are significantly more often used: this is the case where a large distance between a firm and its customers exists, a firm's product quality is difficult to assess, a firm's products are characterized by a limited (but not strong) substitutability, and where a firm is engaged in R&D and introduces innovative products. Trademarks are considerably less frequently used if none of this is the case.
Tree Mortality From Insect Infestation Enhances Carbon Stabilization in Southern Appalachian Forest Soils

Forest insect and pathogen outbreaks may exacerbate anthropogenic climate change if they accelerate soil carbon loss to the atmosphere. We quantified soil respiration and carbon content for nearly a decade after girdling or natural infestation of hemlock (Tsuga canadensis L. Carr., a codominant species in southern Appalachian forests) by hemlock woolly adelgid (Adelges tsugae) to improve understanding of soil carbon response to disturbance from forest insect and pathogens. From 2005 to 2013, net soil respiration was similar among hemlock mortality (~50% basal area reduction) and reference hardwood plots, but both girdled and hemlock woolly adelgid‐infested plots showed greater activities of β‐glucosidase (a cellulose‐hydrolyzing extracellular enzyme), decreased O‐horizon, and decreased fine root biomass. During this period, mineral soil carbon accumulated at a higher rate in hemlock mortality plots than in reference plots in both surface (0–10 cm) and subsurface (10–30 cm) soils, driven by increases in the mineral‐associated fraction of the soil organic matter. In contrast, particulate organic matter (POM) carbon accrued slowly in surface soils and declined in the subsurface of girdled plots. δ13C values of the POM fraction demonstrate increased microbial processing of surface soil organic matter over time, suggesting enhanced decomposition of organic matter in this pool. These findings indicate that hemlock mortality in this system has led to enhanced soil carbon stabilization through the transformation and translocation of carbon from detrital and POM pools to the mineral‐associated organic matter pool. Accelerated responses in the girdled versus naturally infested treatments highlight limitations associated with using girdling to simulate natural mortality.
Existence of partially localized quasiperiodic solutions of homogeneous elliptic equations on R^{N+1}

We consider the equation ∆u+ uyy + f(u) = 0, (x, y) ∈ R × R, (1) where N ≥ 2 and f is a smooth function satisfying f(0) = 0 and f ′(0) < 0. We show that for suitable nonlinearities f of this form equation (1) possesses uncountably many positive solutions which are quasiperiodic in y, radially symmetric in x, and decaying as |x| → ∞ uniformly in y. Our method is based on center manifold and KAM-type results and involves analysis of solutions of (1) in a vicinity of a y-independent solution u∗(x)—a ground state of the equation ∆u+ f(u) = 0 on R .
Resource-restricted growth of eelgrass in New York estuaries: light limitation, and alleviation of nutrient stress by hard clams

Globally, anthropogenic activities have degraded many estuarine habitat types, includ- ing seagrass meadows. The objective of this study was to identify the degree to which light and nutri- ents limit the productivity of eelgrass Zostera marina in Long Island estuaries (NY, USA) while con- currently assessing the ability of hard clams Mercenaria mercenaria to influence Z. marina growth and production. Field surveys were conducted to quantify the extent of eelgrass beds, along with environmental factors potentially constraining eelgrass growth. Experimental studies were con- ducted to determine the extent to which eelgrass is light- or nutrient-limited within the system, and to determine the capacity of hard clams to enhance eelgrass growth in situ. Eelgrass was found in only 14% of the sites sampled, but hard clams were found in 67% of sites with eelgrass. There was a strong longitudinal light gradient in Shinnecock Bay, with an extinction coefficient of 0.88 at the ocean inlet and 2.05 in the most remote regions. Pelagic light levels were inversely correlated with water column chlorophyll levels (p = 0.0027) and eelgrass productivity was strongly correlated with light levels (p < 0.0004), with both being maximal near the ocean inlet. In estuarine regions with high light levels but significantly lower sediment nitrogen (N) content (near ocean inlet), hard clam or sed- iment nutrient additions yielded significantly higher eelgrass productivity and leaf N content (p < 0.001) compared to control plots. Combined with prior research, this study demonstrates that restora- tion of bivalves may benefit the expansion of eelgrass beds in shallow estuaries by relieving light and/or nutrient limitation.
Expression profiling of abiotic-stress-inducible genes in sugarcane.

DROUGHT is an important environmental factor which affects sugarcane productivity world-wide. Production of drought resistant sugarcane via conventional breeding is difficult and a molecular approach to developing drought tolerance in sugarcane may be advantageous. One approach, which has successfully produced drought resistant transgenic plants in other crop species, is the use of transcription factors that regulate the drought response. A set of genes containing C-repeat/dehydration response elements in their promoter are activated when plants are exposed to abiotic stress caused by cold, drought or salt. It has been demonstrated in Arabidopsis that the C-repeat binding factor 4 (CBF4) protein plays a role in regulation of some of these genes during drought adaptation. As a prelude to expressing the CBF4 gene in transgenic sugarcane, we chose to profile the expression of sugarcane orthologues of published, abiotic-stress-inducible genes in wild-type sugarcane in response to abiotic stress. Treatments included exposure of wild-type Q117 sugarcane plants to cold, salt and drought stress. Changes in the expression levels of 4 genes encoding galactional synthase (GolS), early response to dehydration protein 4 (ERD4), late embryogenesis abundant protein 3 (LEA3) and pyrroline-5-carboxylase synthetase (P5CS) were evaluated by real-time PCR analysis. The results showed that GolS and P5CS were induced most strongly during salt stress, ERD4 during drought stress and LEA3 during cold stress. A limited number of transgenic lines of Q117 were produced containing the CBF4 gene under the control of the maize Ubi promoter. Over-expression of CBF4 led to significantly increased expression of ERD4 and P5CS (known targets for CBF activation) when compared to wild-type Q117 plants under normal conditions. Expression levels of GolS and LEA3 were not significantly affected by over-expression of CBF4. Together these results suggest that abiotic-stress-inducible pathways are active in sugarcane and that expression of the Arabidopsis CBF4 gene in transgenic sugarcane can activate these pathways under normal conditions.
Increasing the Resilience of Cyber Physical Systems in Smart Grid Environments using Dynamic Cells

Resilience is an important system property that relies on the ability of a system to automatically recover from a degraded state so as to continue providing its services. Resilient systems have the means of detecting faults and failures with the added capability of automatically restoring their normal operations. Mastering resilience in the domain of Cyber-Physical Systems is challenging due to the interdependence of hybrid hardware and software components, along with physical limitations, laws, regulations and standards, among others. In order to overcome these challenges, this paper presents a modeling approach, based on the concept of Dynamic Cells, tailored to the management of Smart Grids. Additionally, a heuristic algorithm that works on top of the proposed modeling approach, to find resilient configurations, has been defined and implemented. More specifically, the model supports a flexible representation of Smart Grids and the algorithm is able to manage, at different abstraction levels, the resource consumption of individual grid elements on the presence of failures and faults. Finally, the proposal is evaluated in a test scenario where the effectiveness of such approach, when dealing with complex scenarios where adequate solutions are difficult to find, is shown.
Dissemination of Plasmid-mediated qnr, aac(6')-Ib-cr, and qepA Genes Among 16S rRNA Methylase Producing Enterobacteriaceae in Korea

Plasmid-mediated quinolone resistance (PMQR) genes: qnr, aac(6')-Ib-cr, and qepA were investigated among 153 armA and 51 rmtB-positive transconjugants and their 204 clinical isolates of Enterobacteriaceae. Overall, qnrB4 and aac(6')-Ib-cr genes were identified in 52.3% (63 K. pneumoniae, 10 E. coli, 4 E. cloacae, and 3 E. aerogenes) and 24.8% (16 K. pneumoniae, 8 E. coli, 6 S. marcescens, 4 E. cloacae, 3 C. freundii and 1 K. oxytoca) of 153 armA-positive isolates, respectively. Four isolates of K. pneumoniae and two isolates of E. coli positive for armA co-harbored both qnrB4 and aac(6')-Ib-cr. The qepA gene was detected in 11.8% (5 E. coli and 1 K. pneumoniae) of 51 rmtB-positive clinical isolates and their transconjugants. Southern hybridization confirmed the co-localization of qepA and rmtB on a large conjugative plasmid of size between 90 to 170 kb. Inc replicon typing showed that qnrB4/6, aac(6')-Ib-cr, and qepA genes were principally disseminated by IncFIIAs, IncL/M, and IncF plasmids, respectively. This study constitutes the first report of the three known PMQR genes among the 16S rRNA methylase producing Enterobacteriaceae isolates of human origin from Korea.
A COMPARATIVE IN VITRO CYTOTOXICITY STUDY OF COLLOIDAL SILVER AND CHITOSAN STABILIZED SILVER NANOPARTICLES ON MCF-7 AND HEPG2

Recently nanotechnology research was discussed for the generation of nanoparticles as anticancerous agents. It is mandatory to elaborate the application of colloidal silver and chitosan stabilized silver nanoparticles in general and anticancerous property in particular. The present study was aimed to investigate the in vitro cytotoxicity effect of colloidal silver and chitosan stabilized silver nanoparticles against human breast cancer cells (MCF-7) and liver cancer cells (HepG2) towards the development of anticancer drugs. The colloidal silver and chitosan stabilized silver nanoparticles were fabricated by using sodium borohydride as novel reducing agent. It was well characterized by UV, SEM, EDS, XRD, and AFM studies showed spherical shaped nanoparticles in the size range of 20-40nm and in slightly agglomerated form. Surprisingly it also showed cytotoxic effect against MCF-7 and HepG2 cell lines were confirmed by MTT and cell viability assays. There was an immediate induction of cellular damage in terms of loss of cell membrane integrity, oxidative stress and apoptosis were found in the cell which treated with colloidal silver and chitosan stabilized AgNPs. This may be a first report on antiMCF-7 and anti-HepG2 property of colloidal silver and chitosan stabilized AgNPs in the fourth generation of nanoparticle research. It is necessary to study the formulation and clinical trials to establish the nano drug to treat cancer cells.
Updates in Adult Acute Lymphoblastic Leukemia—Current Status of Antigen-targeted Treatments and Immunotherapy

T he outcomes of adult acute lymphoblastic leukemia (ALL) remain inferior to those observed in pediatric populations. Targeted therapy with monoclonal antibodies and immunotherapy represents the most promising new way to fight ALL without significant additive toxicity. Since the use of rituximab in combination chemoimmunotherapy for treatment of B cell lineage ALL, a number of other monoclonal antibodies are under investigation for the treatment of this disease. Deep molecular remissions with anti-CD19and anti-CD22-directed therapy have been shown in relapsed/refractory (R/R) disease, allowing for the opportunity to transplant. Blinatumomab is the first antigen-directed treatment approved for use in R/R ALL. Adoptive cellular therapy with human T cells genetically engineered to express CD19 redirected chimeric antigen receptors (CARs) has also recently demonstrated efficacy in patients with B cell lineage ALL. In this article, we review the therapeutic implications, primary results, and current status of antigen-targeted treatments and immunotherapy in adult B cell lineage ALL.
1 MELTBLOWING : MULTIPLE POLYMER JETS AND FIBER-SIZE DISTRIBUTION AND LAYDOWN PATTERNS

In this work a comprehensive model of three-dimensional configurations of polymer jets in meltblowing from die exit to deposition screen is developed. In addition, multiple jets were modeled simultaneously, as well as deposition on a screen moving normally to the principal jet direction was accounted for. All important properties of polymer melts are used in the simulations, namely density, zero-shear viscosity and the viscoelastic relaxation time. In addition, the material parameters responsible for the temperaturedependent variation of the material properties are used. All the other parameters are the
Effect of environmental variability on habitat selection, diet, provisioning behaviour and chick growth in yellow-nosed albatrosses

To understand how seabird breeding performance is influenced by environmental variability, it is necessary to compare acquisition processes between contrasted situations, and their consequence for reproduction. We present results on variations in distribution at sea, habitat selection, diet and provisioning behaviour of the yellow-nosed albatross Thalassarche chlororhynchos from Amsterdam Island, and their consequence for chick growth, during 2 years, 1996 and 2001, with contrasted environmental conditions. The position of thermal fronts changed between the 2 years, and the waters around Amsterdam were colder in 2001 than in 1996. Satellite tracking and compositional analysis show that in 2001 birds foraged farther and in colder oceanic waters than in 1996, resulting in poorer foraging success in 2001. During both years, fish dominated the diet, with minor interannual differences: albatrosses fed more on fish (including a higher proportion of the nomeid Cubiceps caeruleus) and less on squid and crustaceans in 1996. Nestling provisioning was half the rate in 2001 compared to 1996, and this difference was mainly due to longer trips in 2001, with a bimodal trip length distribution. Consequently, chick growth differed significantly, with lighter chicks at fledging being produced in 2001 compared to 1996, although wing length was similar between the 2 years. This study indicates that, during unfavourable conditions, yellow-nosed albatrosses are able to increase foraging effort by searching for prey at greater distances from the nest, at the expense of offspring condition.
Monte Carlo Tree Search and Its Applications

Monte Carlo tree search (MCTS) is a probabilistic algorithm that uses lightweight random simulations to selectively grow a game tree. MCTS has experienced a lot of success in domains with vast search spaces which historically have challenged deterministic algorithms [3]. This paper discusses the steps of the MCTS algorithm, its application to the board game Go, and its application to narrative generation.
Effects of Ingestion of Bonny Light Crude Oil on Sperm Motility and Morphology of Male Wistar Rats

This study evaluated the effects of Bonny light crude oil (BLCO) on the sperm morphology and sperm motility of young adult male wistar rats. Eighty (80) adult male wistar rats were used for this study, they were divide into four (4) parallel groups A, B, C, and D consisting each of fifteen (15) experimental animals and five (5) control animals. The experimental animals in groups A, B, C, and D received 0.5, 1.5, 2.5, and 3.5ml/kg B.W of BLCO respectively, while the control animals in corresponding groups received the corresponding doses of normal saline via oral gastric intubation for sixty (60) days alternately. At the end of the sixty days, the animals were sacrificed and the spermatozoa was expressed, a homogenate made and used for semen analysis. The percentage motility for normal motility decreased down the group with increase in administered BLCO (A; 79.30%, B; 44.00%, C; 38.00%, D; 15.80% ), while in the control groups, the percentage for both normal motility ( A1; 90.60%, B1; 90.50%, C1; 90.10%, D1; 89.60%) were fairly stable. The total percentage morphology of the defected sperm increased down the group (A; 23.50%, B; 46.80%, C; 59.90%, D; 70.20) with increase in BLCO administered, but despite the varying volume of normal saline administered to each control group, the percentage morphology of normal sperm (A1; 93.80%, B1; 94.60%, C1; 94.20%, D1; 93.00%) remained fairly the stable. This study shows that administration of BLCO, can cause a reduction in the percentage of motile sperm and also abnormal morphology of sperm cells.
CNN-Optimized Image Compression with Uncertainty based Resource Allocation

In this paper, we provide the description of our approach designed for participating the CVPR 2018 Challenge on Learned Image Compression (CLIC). Our approach is a hybrid image coder based on CNN-optimized in-loop filter and mode coding, with uncertainty based resource allocation for compressing the task images. Two solutions were submitted, i.e., “iipTiramisu” and its speedup version “iipTiramisuS”, resulting in 32.14 dB and 32.06 dB in PSNR, respectively. These two results have been ranked No. 1 and 2 on the leaderboard.