Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Service Dogs on Family Members' Psychosocial Functioning.

IMPORTANCE A growing body of evidence supports service dogs' positive psychosocial impact on people with a chronic condition, but very little is known about the effect of service dogs on the family members with whom they live. OBJECTIVE To measure the impact that a service dog may have on family member functioning. DESIGN Cross-sectional with a single time-point assessment. SETTING Data were collected via a self-report survey completed online, over the phone, or by mail. PARTICIPANTS Potential participants were recruited from national service dog provider Canine Assistants. Participants were caregivers or spouses of a person with a disability or illness who either currently had a service dog (n = 51) or was on the waitlist to receive one (n = 77). Participants were 50 family members (46 parents-caregivers and 4 spouses-partners) living with a service dog and 76 family members (68 parents-caregivers and 8 spouses-partners) whose family member was on the waitlist to receive one. OUTCOMES AND MEASURES Participants completed standardized measures to quantify psychosocial health and functioning, health-related quality of life (HRQOL), and family functioning. RESULTS Living with a service dog was most closely associated with less health-related worry and better overall psychosocial health and emotional functioning, less total family impact from the chronic condition, and better emotional HRQOL. CONCLUSIONS AND RELEVANCE These findings provide preliminary evidence that, in addition to having an impact on recipients, service dogs can affect several aspects of family members' psychosocial health and functioning. WHAT THIS ARTICLE ADDS This research demonstrates that the impact of a service dog may extend beyond the recipient and have positive impacts on family members' psychosocial functioning as well. Occupational therapy practitioners should include family members in discussions regarding the integration of a service dog into the home and recognize the potential for family-wide effects from the service dog's assistance.
Rapidly Progressive Multisutural Craniosynostosis in a Patient With Jackson-Weiss Syndrome and a De Novo FGFR2 Pathogenic Variant

Little is currently known about the mechanisms by which pathogenic variants of FGFR2 produce changes in the FGFR protein and influence the clinical presentation of affected individuals. We report on a patient with a de novo pathogenic variant of FGFR2 and a phenotype consistent with Jackson-Weiss syndrome who presented with delayed, rapidly progressive multisutural craniosynostosis and associated medical complications. Using 3-dimensional modeling of the FGFR protein, we provide evidence that this variant resulted in abnormal dimerization and constitutive activation of FGFR, leading to the Jackson-Weiss phenotype. Knowledge regarding the correlation between genotype and phenotype of persons with FGFR2-related craniosynostosis has the potential to allow for anticipation of medical complications, institution of early treatment, and improved clinical outcomes.
Key Information Expansion Applied in Spoken Document Classification based on Lattice

Traditionally, query words or key words in spoken document classification are generated by manual. In this paper, based on CHI-square, TFIDF and maximum poster probability (MPP) features, a new hybrid feature for key information extraction is proposed. It can combine the advantages of these three features, and the weight of each word in hybrid feature can be further integrated into the classification system. Here, the weights of key words can reveal the relationship between words and topic to some extent. Furthermore, when the query words or key words are not enough, key information expansion part based on focus score can be added to dig the latent information about the topic. In the key information expansion part, not only the documents with key words occurring but also the other documents with no key word participate into the expansion procedure. Additionally, in the classification system, document length as prior information is adopted when no query is found. The whole classification system is based on lattice, which has more information than 1-best result in speech recognition system. Among CHI-square, TFIDF and MPP, the system performance of MPP is a little worse than the others. CHI-square is a little better than TFIDF when the key words number is increasing. Among these feature, hybrid feature can almost obtain the best performance under the same condition. Combined with document length information, the classification system performance is further enhanced, especially for less key information condition. Experiments show that when the system is combined weight and document length information, hybrid feature can obtain the best performance with a MAP of 0.7817 under 50 key words. When key information is not enough, key information expansion can improve the system performance when only 1, 5, 10 key words here. In the proposed key information expansion approach, since the focus factor is introduced to adjust the effect of documents with no key words, some function words can be avoided to some extent, and the number of expansion words can be under control.
KIT mutation in a naïve succinate dehydrogenase‐deficient gastric GIST

Up to 85% of gastrointestinal stromal tumors (GIST) harbor mutually exclusive mutations in the KIT or the PDGFRA gene. Among others, known as wild type GIST, succinate dehydrogenase (SDH)‐deficient tumors develop due to genetic or epigenetic alterations in any of four SDH genes. Herein, we present a unique case of SDH‐deficient GIST with an unusual heterogeneous SDHA and SDHB staining pattern and mutations detected in the SDHA and KIT gene. A 50‐year‐old patient presented with a 5 cm large gastric tumor with a multinodular/plexiform growth pattern, mixed epithelioid and spindle cell morphology, and focal pronounced nuclear atypia with hyperchromasia and high mitotic activity. Immunohistochemically, CD117 and DOG‐1 were positive. SDHB and SDHA stains showed loss of expression in some of the nodules, whereas others presented with an unusually weak patchy positivity. Molecular analysis revealed a point mutation in exon 5 of the SDHA gene and a mutation in exon 11 of the KIT gene. We hypothesize that based on the allele frequency of SDHA and KIT mutations the tumor is best regarded as SDH‐deficient GIST in which the SDHA mutation represents the most likely driver mutation. The identified KIT mutation raises the distinct possibility that the KIT mutation is a secondary event reflecting clonal evolution. This is the first case of a treatment naïve GIST harboring a somatic SDHA and a KIT mutation, challenging the dogma that oncogenic mutations in treatment naïve GIST are mutually exclusive.
Proteomic Analysis of MeJa-Induced Defense Responses in Rice against Wounding

The role of jasmonates in defense priming has been widely recognized. Priming is a physiological process by which a plant exposed to low doses of biotic or abiotic elicitors activates faster and/or stronger defense responses when subsequently challenged by a stress. In this work, we investigated the impact of MeJA-induced defense responses to mechanical wounding in rice (Oryza sativa). The proteome reprogramming of plants treated with MeJA, wounding or MeJA+wounding has been in-depth analyzed by using a combination of high throughput profiling techniques and bioinformatics tools. Gene Ontology analysis identified protein classes as defense/immunity proteins, hydrolases and oxidoreductases differentially enriched by the three treatments, although with different amplitude. Remarkably, proteins involved in photosynthesis or oxidative stress were significantly affected upon wounding in MeJA-primed plants. Although these identified proteins had been previously shown to play a role in defense responses, our study revealed that they are specifically associated with MeJA-priming. Additionally, we also showed that at the phenotypic level MeJA protects plants from oxidative stress and photosynthetic damage induced by wounding. Taken together, our results add novel insight into the molecular actors and physiological mechanisms orchestrated by MeJA in enhancing rice plants defenses after wounding.
Drug treatment strategies for depression in Parkinson disease

ABSTRACT Introduction: Depression is a common non-motor symptom in Parkinson disease (PD), occurring in approximately 20% of patients with PD. While depression can occur anytime in the disease process, it predates PD diagnosis in about 30% of patients. Between 20% and 60% of depressed patients with PD are either without recognition or treatment of their depression. Areas covered: The pathophysiology of depression in PD is unclear. There are several structural changes seen in depressed patients with PD that are also seen in patients with depression. In addition, the neurotransmitters dopamine, serotonin, and norepinephrine are all depleted in PD. This article covers the pharmacological treatment of depression in PD; this involves standard antidepressant treatment such as selective serotonin reuptake inhibitors, tricyclic antidepressants, serotonin and norepinephrine reuptake inhibitors, and monoamine oxidase inhibitors. As with depression not associated with PD, most treatment is partially successful. Non-pharmacological approaches are also touched upon. Expert opinion: Most antidepressant therapy shows partial efficacy in patients with PD. However, there is a need for better study design as well as more comparative studies for the treatment of depression in PD. Biomarkers will help identify patients with PD and depression earlier in the future.
Elevated maternal linoleic acid reduces circulating leptin concentrations, cholesterol levels and male fetal survival in a rat model

Linoleic acid consumption is increasing in Western populations. We investigated whether elevated linoleic acid in pregnancy was deleterious to mothers or offspring. Maternal and fetal body and organ weights were not affected by elevated linoleic acid consumption. Maternal lipids and leptin were altered following elevated linoleic acid consumption. Male offspring numbers were reduced following elevated linoleic acid consumption.
Endogenous Tariff Formation with Intra-Industry Trade

Previous theoretical contributions on endogenous tariff formation have focused on trade mod-els with homogeneous goods and constant returns to scale. This paper investigates the political equilibrium of trade policy when economic structure is instead characterized by differentiated products and increasing returns to scale and there exists intra-industry trade. The result shows that endogenous tariffs are positive for all industries with non-negligible shares of world pro-duction. However, the level of protection is less than the optimal tariff that would otherwise be imposed by a benevolent government in an unorganized industry, and higher in an organized industry. The protection provided to all unorganized (organized) industries increases (falls) with the relative weight the government attaches to aggregate welfare vis-` a-vis campaign contribu-tions and falls with the fraction of the population that belongs to a lobby group. The model also indicates that the endogenous tariff level in an organized industry might be explosive. The higher is the fraction of the population represented by a lobby and the higher is the weight on aggregate welfare in the government’s objective function, the smaller is the possibility for such an explosive tariff.
High-intensity aerobic training lowers blood pressure and modulates the renal renin-angiotensin system in spontaneously hypertensive rats

ABSTRACT Background: This study aimed to verify the effects of high-intensity aerobic training (HIAT) on BP control and renin-angiotensin system (RAS) components in renal tissue of SHR. Ten SHRs received HIAT or control for 8-weeks. At the end of the training, the SBP showed a reduction of ~ 30mmHg (p < .01) in HIAT and increased by ~ 15 mmHg in the control group. HIAT resulted in a higher release of nitrite, IL-6, ACE2 and ATR2. These results indicated an association between BP, NO and renal RAS. Abbreviations: JAA: writing, carried out all experimental procedures, performed statistical analysis, original draft and revised manuscript DMS: data interpretation, formal analysis, writing, editing and revised manuscript BAP: carried all experimental procedures, revised manuscritpt CPCG: carried all experimental procedures, revised manuscritpt MEN: experimental procedures, revised manuscript and data interpretation RWP: drafted and revised manuscript RCA: writing, experimental procedures, revised manuscript JP: writing, data interpretation and revised manuscript OLF: writing, original draft and revised manuscript.
Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism of genomics

The causative agents of leptospirosis are responsible for an emerging zoonotic disease worldwide. One of the major routes of transmission for leptospirosis is the natural environment contaminated with the urine of a wide range of reservoir animals. Soils and surface waters also host a high diversity of non-pathogenic Leptospira and species for which the virulence status is not clearly established. The genus Leptospira is currently divided into 35 species classified into three phylogenetic clusters, which supposedly correlate with the virulence of the bacteria. In this study, a total of 90 Leptospira strains isolated from different environments worldwide including Japan, Malaysia, New Caledonia, Algeria, mainland France, and the island of Mayotte in the Indian Ocean were sequenced. A comparison of average nucleotide identity (ANI) values of genomes of the 90 isolates and representative genomes of known species revealed 30 new Leptospira species. These data also supported the existence of two clades and 4 subclades. To avoid classification that strongly implies assumption on the virulence status of the lineages, we called them P1, P2, S1, S2. One of these subclades has not yet been described and is composed of Leptospira idonii and 4 novel species that are phylogenetically related to the saprophytes. We then investigated genome diversity and evolutionary relationships among members of the genus Leptospira by studying the pangenome and core gene sets. Our data enable the identification of genome features, genes and domains that are important for each subclade, thereby laying the foundation for refining the classification of this complex bacterial genus. We also shed light on atypical genomic features of a group of species that includes the species often associated with human infection, suggesting a specific and ongoing evolution of this group of species that will require more attention. In conclusion, we have uncovered a massive species diversity and revealed a novel subclade in environmental samples collected worldwide and we have redefined the classification of species in the genus. The implication of several new potentially infectious Leptospira species for human and animal health remains to be determined but our data also provide new insights into the emergence of virulence in the pathogenic species.
Mineral Soils as Carriers for Rhizobium Inoculants

Mineral soil-based inoculants of Rhizobium meliloti and Rhizobium phaseoli survived better at 4°C than at higher temperatures, but ca. 15% of the cells were viable at 37°C after 27 days. Soil-based inoculants of R. meliloti, R. phaseoli, Rhizobium japonicum, and a cowpea Rhizobium sp. applied to seeds of their host legumes also survived better at low temperatures, but the percent survival of such inoculants was higher than peat-based inoculants at 35°C. Survival of R. phaseoli, R. japonicum, and cowpea rhizobia was not markedly improved when the cells were suspended in sugar solutions before drying them in soil. Nodulation was abundant on Phaseolus vulgaris derived from seeds that had been coated with a soil-based inoculant and stored for 165 days at 25°C. The increase in yield and nitrogen content of Phaseolus angularis grown in the greenhouse was the same with soil-and peat-based inoculants. We suggest that certain mineral soils can be useful and readily available carriers for legume inoculants containing desiccation-resistant Rhizobium strains.
Framework for parallelisation on big data

The parallelisation of big data is emerging as an important framework for large-scale parallel data applications such as seismic data processing. The field of seismic data is so large or complex that traditional data processing software is incapable of dealing with it. For example, the implementation of parallel processing in seismic applications to improve the processing speed is complex in nature. To overcome this issue, a simple technique which that helps provide parallel processing for big data applications such as seismic algorithms is needed. In our framework, we used the Apache Hadoop with its MapReduce function. All experiments were conducted on the RedHat CentOS platform. Finally, we studied the bottlenecks and improved the overall performance of the system for seismic algorithms (stochastic inversion).
A complete power estimation methodology for DSP blocks in FPGAs

This work proposes a complete commercial power model for DSP blocks in FPGAs. A pin activities model is developed to estimate the transitions densities at the output of the DSP blocks given the switching activities at the inputs. Such a pin activities model is important in estimating power dissipation during the pre-layout design phase. The power model estimates the total power dissipation in the DSP blocks using the knowledge of all the transitions densities of the inputs and outputs, which are estimated by the proposed pin activities model. The average error of the proposed power model on the design level is less than 2%.
A longitudinal analysis of morphological characteristics and body proportionality in young elite sprint paddlers

ABSTRACT Introduction: There are certain anthropometric attributes common to most high-level paddlers and among the determinants for optimal performance consecution in senior categories. Objective: The present investigation aimed to determine the evolution of morphological characteristics of elite paddlers during adolescence and to compare them with the values exhibited by Olympic competitors. Methods: In a longitudinal study, thirteen young elite paddlers (seven boys and six girls) completed a battery of anthropometric tests (heights, weight, girths, lengths, and sum of skinfolds) and on-water performance assessments (200 and 500 m) during three consecutive years. Results: Body mass and upper body sizes significantly change over the years (p < .05), especially in boys. Both male and female paddlers presented significant differences and large effect sizes in muscle mass and skin mass values (η2p > .64) whereas bone mass and fat mass remained stable from the 1st to the 3rd year. Proportionality analysis revealed girths and breadths differences in arm and chest variables as well as large effect sizes in biacromial breadth among all years (η2p > .62; p < .05), particularly in boys. Similarly, significant improvements in 200-m performance times were observed for both sexes. Conclusions: The findings of the current investigation might suggest a tendency towards a leaner and more robust morphological profile of elite paddlers in the transition from young to senior categories. In addition, the presence of superior relative body dimensions from young categories seems to be paramount in the evolution to later successful paddling.
Nearshore seascape connectivity enhances seagrass meadow nursery function.

Diverse habitats composing coastal seascapes occur in close proximity, connected by the flux of materials and fauna across habitat boundaries. Understanding how seascape connectivity alters important ecosystem functions for fish, however, is not well established. For a seagrass-dominant seascape, we predicted that configuration and composition of adjacent habitats would alter habitat access for fauna and trophic subsidies, enhancing nursery function for juvenile fish. In an extensive Zostera marina seagrass meadow, we established sites adjacent to (1) highly complex and productive kelp forests (Nereocystis luetkeana), (2) unvegetated sand habitats, and (3) in the seagrass meadow interior. Using SCUBA, we conducted underwater observations of young-of the-year (YOY) rockfish (Sebastes spp.) recruitment across sites. Using generalized linear mixed effects models, we assessed the role of seascape adjacency relative to seagrass provisions (habitat complexity and prey) on YOY recruitment. YOY rockfish collections were used to trace sources of allochthonous vs. autochthonous primary production in the seagrass food web, via a δ13 C and δ15 N isotopic mixing model, and prey consumption using stomach contents. Overall, seagrass nursery function was strongly influenced by adjacent habitats and associated subsidies. Allochthonous N. luetkeana was the greatest source of energy assimilated by YOY rockfish within seagrass sites. In seagrass sites adjacent to N. luetkeana kelp forests, YOYs consumed higher quality prey, which corresponded with better body condition relative to sites adjacent to sand. Moreover, kelp forest adjacency enhanced YOY rockfish recruitment within the seagrass meadow, suggesting that habitat complexity is a key seascape feature influencing the nursery function of nearshore habitats. In general, to promote seascape connectivity, the conservation and restoration of nursery habitats should prioritize the inclusion of habitat mosaics of high structural complexity and productivity. We illustrate and emphasize the importance of using a seascape-level approach that considers linkages among habitats for the management of important nearshore ecosystem functions.
Thermo-Oxidative Decomposition of Lovage (Levisticum officinale) and Davana (Artemisia pallens) Essential Oils under Simulated Tobacco Heating Product Conditions

Summary The thermo-oxidative decomposition of lovage (Levisticum officinale) and davana (Artemisia pallens) essential oils has been studied by pyrolysis-gas chromatography/mass spectrometry in 9% oxygen and 91% nitrogen atmosphere at 300 °C to simulate low-temperature tobacco heating conditions. Both lovage and davana oils contain numerous chemical substances; the main components of both oils are various oxygen-containing compounds. Isobenzofuranones are the most important constituents of lovage oil, and their relative intensity changed significantly during oxidative pyrolysis. (Z)-ligustilide underwent two kinds of decomposition reactions: an aromatization reaction resulting in the formation of butylidenephthalide and the scission of the lactone ring with the elimination of carbon dioxide or carbon monoxide. Davanone is the main component of davana oil, which did not decompose considerably during low-temperature oxidative pyrolysis. However, the relative yield of the second most intensive component, bicyclogermacrene, reduced markedly due to bond rearrangement reactions. Davana ether underwent oxidation reactions leading to the formation of various furanic compounds. The changes in the composition of both essential oils could be interpreted in terms of bond splitting, intramolecular rearrangement mechanisms and oxidation reactions of several constituents during low-temperature oxidative pyrolysis. The applied thermo-oxidative method was found to be suitable to study the stability of the essential oils and monitor the decomposition products under simulated tobacco heating conditions. In spite of the complicated composition of the essential oils, no evidence for interaction between the oil components was found. [Beitr. Tabakforsch. Int. 29 (2020) 27–43]