Miracle-dz/UniFAR-FTUs huggingface dataset:
Wearable devices for sudden unexpected death in epilepsy prevention

Sudden unexpected death in epilepsy (SUDEP) is most often associated with the occurrence of generalized tonic–clonic seizures (GTCS), a seizure type that can now be detected with high sensitivity and specificity by wearable or bed devices. The recent development in such devices and their performance offer multiple opportunities to tackle SUDEP and its prevention. Reliable GTCS detection might help physicians optimize antiepileptic treatment, which could in turn reduce the risk of SUDEP. GTCS‐triggered alarms can lead to immediate intervention by caregivers that are also likely to decrease the odd of SUDEP. The biosignals used to detect GTCS might provide novel SUDEP biomarkers, in particular, by informing on several important characteristics of the ictal and postictal periods (type of GTCS, duration of tonic phase, rotation in the prone position, presence and duration of postictal immobility and bradycardia, rise in electrodermal activity). Other biosensors not yet used for detecting GTCS might provide complementary information, such as the presence and intensity of ictal/postictal hypoxemia. The above biomarkers, if strongly predictive, could help identify patients at very high risk of SUDEP, enabling better assessment of individual risk, as well as selection of appropriate patients for clinical studies aiming at preventing SUDEP. The same biosignals could also be used as ancillary biomarkers to test the impact of various interventions before moving to highly challenging randomized controlled trials with SUDEP as a primary outcome.
Open Innovation in Libraries

“Open innovation” means the participation of an institution’s stakeholders (customers, suppliers, competitors, etc.) in its innovation processes. With the advent of the knowledge society, the role of libraries is deeply changing towards digital libraries, special services, and the provision of spaces. However, how should libraries realize such knowledge and innovation projects? Concerning libraries, open innovation integrates the views of users (as customers), software houses or design companies (as suppliers) as well as other libraries (as competitors) into the development strategy of a library. Innovation processes include information inflows and information outflows. In this paper, a theoretical model of open innovation in the context of the library institution is presented. We describe results of a survey and introduce paradigmatic case studies of libraries, which deployed open innovation and networked governance. These libraries show examples of innovation processes on a scale from small to large.
Reasoning about Complexity - Software Models as External Representations

Programming is traditionally considered to be an activity which aims only to produce a software artefact as its primary goal. With this view programming languages are simply the notations which define these artefacts. This paper examines the relationships between internal representations (mental models) and external representations (notations and other forms) arguing that program code behaves as an external representation in a similar way to mathematical or logical notations but with the added property that code can be executed and its notational consequences observed. Furthermore some environments allow program operation to be manipulated at run-time; we propose that these systems also operate as external representations and that programming language statements and their run-time environments can thereby be utilised as reasoning systems to promote the exploration and discovery of new understandings. In this context we consider NetLogo as a framework for reasoning about complex and emergent systems, evaluating its suitability from a representational perspective.
ESTUDO DO PROCESSO DE ADSORÇÃO DE AZUL DE METILENO EM MEIO AQUOSO EMPREGANDO SILICA SBA-15 COMO ADSORVENTE

A silica SBA-15 e um material mesoporoso com grande potencial de aplicacao, inclusive no processo de adsorcao. Levando esse fator em consideracao objetivou-se nesse trabalho sintetizar e caracterizar a silica SBA-15 nas temperaturas de 80°C, 105°C e 120°C e estudar a sua capacidade de adsorcao do corante azul de metileno em meio aquoso em diferentes condicoes de concentracao e pH. Foi verificado que a silica sintetizada na temperatura de 80°C apresentou maior eficiencia de adsorcao. Tal fato pode ser explicado pela maior area superficial dessa silica, apresentando assim mais sitios de ligacao, favorecendo a adsorcao. A combinacao que obteve uma maior adsorcao no teste inicial foi a silica sintetizada a 80°C com o azul de metileno na concentracao de 100 mg.L -1 . Posteriormente, foi verificado que o pH 9,0 foi o que obteve a maior eficiencia de adsorcao.
Online Retailing Channel Addition: Risk Alleviation or Risk Maker?

The retailing industry traditionally considers the optimal products selection and pricing problem, a complex and challenging one, from marketing and consumer behavior’s perspectives. In this study, we take a risk perspective and offer an alternative solution to tackling the problem, echoing the most recent literature that looks at nonrisk aspects, such as expected consumer preference, market size and predicted profitability. Adopting a mean-variance framework, our approach explicitly takes into account the interconnectedness of retail products and their impact on risk at the portfolio (retailer) level. Extending the analysis to multiplechannel decisions, our results suggest that the introduction of a new retailing channel (e.g. online shops) can reduce the portfolio risk, whereas a lack of synergy between the new channel and the existing ones may lead to a negative impact on the overall performance. We also provide managerial implications on several conditions when retailers are more economically inclined to introduce more retail channels. Interestingly, our model indicates that larger retailers are less likely to expand their
The Impact of Early Numeracy Intervention on Kindergarten Students

The purpose of this study was to explore the effectiveness of early numeracy intervention with kindergarten students. In order to grow a stronger understanding of how providing mathematics intervention can benefit students, the intervention was provided to kindergarten students aimed to seek answers to how providing the earliest possible intervention can positively impact the achievement gap and a child’s understanding of number. This study explored the impact early numeracy intervention had on five kindergarten students and compared their growth to those of their peers not receiving intervention to determine the positive impact providing Response to Intervention had on kindergarten students. Quantitative and qualitative methods of data were collected using the AIMSweb Test of Early Numeracy, observations, and student work samples were collected to analyze the effectiveness of the intervention. Independent sample t-tests alongside of the constant comparative methods of data analyses were done to triangulate all sources of data all indicated that the early numeracy intervention had a positive impact on the five students whom participated. Over a six week Tier 2 intervention cycle, each of the five students improved their ability to count, understand cardinality, discriminate between numbers one through ten, and began improving their knowledge of the counting sequence within ten. THE IMPACT OF EARLY NUMERACY INTERVENTION 3
Salivary micro RNA as a potential biomarker in oral potentially malignant disorders: A systematic review

Oral potentially malignant disorders (OPMD) are oral mucosal disorders which have a high potential to turn into malignancy. A recent report suggests that 16%–62% of epithelial dysplasia cases of OPMD undergo malignant transformation, showing the need for early detection of malignancy in these disorders. Micro RNA (miRNA) plays an important role in cellular growth, differentiation, apoptosis, and immune response, and hence, deregulation of miRNA is considered a signature of oral carcinogenesis. A search was done using MeSH terms in the PubMed, ScienceDirect databases, hand search, and finally, six studies were included in this systematic review. A total of 167 patients with oral cancer, 78 with OPMDs, 147 healthy controls, and 20 disease controls were analyzed for the expression of salivary miRNAs. Quality assessment based on the Quality Assessment of Diagnostic Accuracy Studies 2 tool was used to obtain a risk of bias chart using Revman 5.3 software and it was proved that the study done by Zahran et al. in 2015 had a low risk of bias. The results of this study revealed upregulated miRNA 184 with an area under the curve (AUC) of 0.86 and miRNA 21 with an AUC of 0.73 and downregulated miRNA 145 with an AUC of 0.68, which proved that these miRNAs are significant in detecting early malignancy in OPMD and should be further analyzed in various populations. This systematic review explored the potential of expression of salivary miRNA in OPMD for future studies. This could pave the way to utilize saliva as a surrogate marker in diagnosing early malignant changes in OPMD.
Extraction Of Technical Information From Normative Documents Using Automated Methods Based On Ontologies : Application To The Iso 15531 Mandate Standard - Methodology And First Results

Problems faced by international standardization bodies become more and more crucial as the number and the size of the standards they produce increase. Sometimes, also, the lack of coordination among the committees in charge of the development of standards may lead to overlaps, mistakes or incompatibilities in the documents. The aim of this study is to present a methodology enabling an automatic extraction of the technical concepts (terms) found in normative documents, through the use of semantic tools coming from the field of language processing. The first part of the paper provides a description of the standardization world, its structure, its way of working and the problems faced; we then introduce the concepts of semantic annotation, information extraction and the software tools available in this domain. The next section explains the concept of ontology and its potential use in the field of standardization. We propose here a methodology enabling the extraction of technical information from a given normative corpus, based on a semantic annotation process done according to reference ontologies. The application to the ISO 15531 MANDATE corpus provides a first use case of the methodology described in this paper. The paper ends with the description of the first experimental results produced by this approach, and with some issues and perspectives, notably its application to other standards and, or Technical Committees and the possibility offered to create pre-defined technical dictionaries of terms.
Predictors of Coordinated and Comprehensive Care Within a Medical Home for Children With Special Healthcare (CHSCN) Needs

The purpose of this study was to examine predictors of coordinated and comprehensive care within a medical home among children with special health care needs (CSHCN). The latest version of the National Survey of Children with Special Health Care Needs (NS-CSHCN) employed a national random-digit-dial sample whereby US households were screened, resulting in 40,242 eligible respondents. Logistic regression analyses were performed modeling the probability of coordinated, comprehensive care in a medical home based on shared decision-making and other factors. A total of 29,845 cases were selected for inclusion in the model. Of these, 17,390 cases (58.3%) met the criteria for coordinated, comprehensive care in a medical home. Access to a community-based service systems had the greatest positive impact on coordinated, comprehensive care in a medical home. Adequate insurance coverage and being White/Caucasian were also positively associated with the dependent variable. Shared decision-making was reported by 72% of respondents and had a negative, but relatively negligible impact on coordinated, comprehensive care in a medical home. Increasing age, non-traditional family structures, urban residence, and public insurance were more influential, and negatively impacted the dependent variable. Providers and their respective organizations should seek to expand and improve health and support services at the community level.
Photographic Disclosure in Facebook and Relational Closeness with Others

Prior research has identified the usefulness of social media in the maintenance of relationships. Such research is predominantly based on overall platform use, the use and affordances of multiple different communication features, or the text-based content of disclosed messages. Little research exists into the disclosure effects of different photographic content, the frequency at which it is shared and how this associates with differences in relational closeness. This research gap becomes increasingly poignant with the mass adoption of social media, the existence of multiple relationship types within these platforms, and the increase in sites based on photographic disclosure alone. This research examines the implications of the perceived frequency of disclosure in Facebook on relational closeness with different relationship types. Survey findings (N=445) show that perceived frequency of posting photographs is significantly associated with changes in relational closeness (companionship, intimacy, support), differing by the relationship held and the photographic depiction.
Optical switching technology comparison: optical MEMS vs. other technologies

Optical switching technologies are very crucial to future mobile broadband all-optical IP networks. Many different optical switching technologies are currently available or under development. The main purpose of the article is to conduct performance comparisons on optical switching technologies in terms of basic performance, network requirements, and system requirements based on a literature survey. The technologies include switching based on optical microelectromechanical systems (MEMS), thermal optical switching, electro-optic switching, and acousto-optic switching technologies. Each optical switching technology has unique performance characteristics specific to the utilized optical phenomena. It might be crucial to integrate some technologies together to achieve a better solution for optical switching. Optical switching is a very hot topic attracting much research effort. Optical MEMS-based switching technology might be one of the most promising approaches at present. Many new optical switching technologies might be created in the near future. Through the impact of nanotechnology, some innovative approaches to optical switching might emerge.
The Melatonin Analog IQM316 May Induce Adult Hippocampal Neurogenesis and Preserve Recognition Memories in Mice

Neurogenesis in the adult hippocampus is a unique process in neurobiology that requires functional integration of newly generated neurons, which may disrupt existing hippocampal network connections and consequently loss of established memories. As neurodegenerative diseases characterized by abnormal neurogenesis and memory dysfunctions are increasing, the identification of new anti-aging drugs is required. In adult mice, we found that melatonin, a well-established neurogenic hormone, and the melatonin analog 2-(2-(5-methoxy-1H-indol-3-yl)ethyl)-5-methyl-1,3,4-oxadiazole (IQM316) were able to induce hippocampal neurogenesis, measured by neuronal nuclei (NeuN) and 5-bromo-2′-deoxyuridine (BrdU) labeling. More importantly, only IQM316 administration was able to induce hippocampal neurogenesis while preserving previously acquired memories, assessed with object recognition tests. In vitro studies with embryonic neural stem cells replicated the finding that both melatonin and IQM316 induce direct differentiation of neural precursors without altering their proliferative activity. Furthermore, IQM316 induces differentiation through a mechanism that is not dependent of melatonergic receptors (MTRs), since the MTR antagonist luzindole could not block the IQM316-induced effects. We also found that IQM316 and melatonin modulate mitochondrial DNA copy number and oxidative phosphorylation proteins, while maintaining mitochondrial function as measured by respiratory assays and enzymatic activity. These results uncover a novel pharmacological agent that may be capable of inducing adult hippocampal neurogenesis at a healthy and sustainable rate that preserves recognition memories.
Moduli spaces of Hecke modifications for rational and elliptic curves

We propose definitions of complex manifolds ${\cal H}(T^2,n)$ for $n \in \mathbb{N}$ that could potentially be used to construct the symplectic Khovanov homology of $n$-stranded links in lens spaces. The space ${\cal H}(T^2,n)$ is defined in terms of Hecke modifications of rank 2 vector bundles over an elliptic curve. We undertake a detailed study of such Hecke modifications: we show which vector bundles can Hecke modify to which, and in what directions. We also describe explicit morphisms of vector bundles that represent all possible Hecke modifications of all possible rank 2 vector bundles on elliptic curves. Using these results, we explicitly characterize the space ${\cal H}(T^2,n)$ for $n = 0, 1, 2$, and we describe an embedding of ${\cal H}(T^2,n)$ into the moduli space $M^{ss}(T^2,n+1)$ of rank 2 semistable parabolic bundles. For comparison, we present analogous results for the case of rational curves, for which the corresponding space of Hecke modifications ${\cal H}(S^2,n)$ is isomorphic to a space ${\cal Y}(S^2,n)$ defined by Seidel and Smith that can be used to compute the symplectic Khovanov homology of $n$-stranded links in $S^3$.
Value Co-Creation and Co-Destruction in Online Video Games: An Exploratory Study and Implications for Future Research

In this empirical study we studied how players of online video games co-create and co-destroy value. From players’ perceptions we identified that value co-creation and co-destruction occur amid themes of giving feedback and building relations. Feedback encourages players but it may also be harmful in the form of verbal abuse. Building relations relates to making friends in general but also on an international level. Building relations also relates to competition that creates a bad spirit. The most intensive interplay between value co-creation and co-destruction was found in gaming groups. Gaming groups motivate players to engage in intense gameplay, but at the same time they are resource-demanding with respect to time and mental capacity. In conclusion, we argue that further study is required of the ways that value co-creation and co-destruction interact in online video games.
Pay-per-download or Freemium: Revenue Models in a Competitive Mobile App Market

This paper examines the revenue model selection of app developers in a duopoly setting. Two developers offering vertically-differentiated apps can adopt either a pay-per-download or a freemium strategy. Under the pay-per-download strategy, consumers pay a fee to acquire the app. Under the freemium strategy, consumers are offered with a free basic version and can choose to pay an additional fee for the full version. A game theoretical model is used to analyze the competition in the presence of network effect and learning effect. We find that when the quality difference is moderate, the pay-per-download strategy is optimal for the high-quality app if the quality of basic version is low, otherwise freemium strategy is optimal. Responding to the pay-per-download strategy of the high-quality app, adopting the pay-per-download strategy is optimal for the low-quality app if quality of basic version is high, otherwise freemium strategy is adopted.
Learning rate schedules for self-organizing maps

Kohonen maps have been successfully applied for data reduction and density approximation. Unfortunately, the choice of the neighborhood function and the learning rate in the Kohonen model remains empirical. We present a new statistically motivated approach to determine the contribution of each data presentation during training on the final position of the units of the trained map. Experimental results show that employing the commonly used learning rates leads to unit locations which are overly influenced by the later presentations (i.e., last 20% of data points in the finite training set). Better learning rate schedules and neighborhood functions are then determined which allow more uniform contributions of the training data on the unit locations. These improved rates are shown to be a suitable generalization of the standard rates given by stochastic approximation theory for a self-organizing map of units.
Prevalence and Predictors of Depression after Stroke - Results from a Prospective Study

BACKGROUND: A depression following a stroke (Post Stoke Depression-PSD) is the most common complication of a stroke that has a negative effect on the result after the stroke. A better definition of the risk factors of the disease will provide for better prediction and treatment. AIM: To research identification of the risk factors for PSD, typical for the Macedonian population, which will help in early prediction, timely diagnosis and treatment of the disease? MATERIAL AND METHODS: We carried out a prospective study in order to determine the prevalence and the risk factors of PSD in 100 patients treated at the hospital in Tetovo. The severity, localisation and the functional outcome of the stroke have been examined as potential risk factors for discharge and after 5 months. The symptoms of depression were quantified using the Hamilton Depression Rating Scale (HAM-d). RESULTS: On discharge, 81% of the patients were diagnosed with PSD, and 67% had PSD after 5 months. A statistically significant codependence of p < 0.05 was registered between PSD and the level of functional dependence for activities of daily living (ADL); PSD and the severity of the stroke; and PSD and the level of disability on both examinations. In most patients with PSD, an ischemic stroke in the right middle cerebral artery has been diagnosed; the percentage difference between the other localisations is statistically significant (p = 0.0436; p = 0.0002). CONCLUSION: There is an increased risk of PSD for immobile patients, those incapable of activities of daily living (ADL), with ischemic stroke in the right middle cerebral artery. A PSD screening and additional studies for better prediction are required.
The Second Society for Simulation in Healthcare Research Summit: Beyond our Boundaries

Summary Statement In this article, we report on the Second Society for Simulation in Healthcare Research Summit held in 2017. This meeting succeeded the First Research Summit from 2011 with the goal of advancing the scope of healthcare simulation research. During the one and a half day summit, some of the world's leading experts in simulation, healthcare, and simulation in healthcare convened to discuss ideas about what research goals would be most beneficial to the healthcare simulation community, and what could be done to achieve them. We describe the rationale for the meeting, the organization, the program, and the articles that emerged from the Summit, which are found in this supplemental issue of Simulation in Healthcare.