Miracle-dz/UniFAR-FTUs huggingface dataset:
A preliminary investigation of corpus callosum and anterior commissure aberrations in aggressive youth with bipolar disorders.

OBJECTIVE Although behavioral deficits in bipolar disorder (BPD) are well described, the specific brain white matter (WM) disruptions have not been completely characterized, and neural mechanisms underlying dysfunction in BPD are not well established, particularly for youth with BPD and aggression. This preliminary study utilized diffusion tensor imaging (DTI) to investigate commissural tracts (corpus callosum [CC] and anterior commissure [AC]) in youth with BPD, because disruption of interhemispheric communication may contribute to the emotional deficits that are characteristic of the illness. METHOD DTI was used to investigate WM in 10 youth (7-17 years of age) with BPD and 10 typically developing age-matched controls. Tract-based spatial statistics voxel-wise analysis was used to compare fractional anisotropy (FA) of the two groups. We specifically focused on five subdivisions of the midsagittal CC as well as on the decussation of AC, which connects the temporal lobes. Exploratory correlations between FA values and life history of aggression scores were calculated for the BPD group. RESULTS Youth with BPD had significantly lower FA values in the callosal genu and AC. FA values in the AC were negatively correlated with a life history of aggression in the BPD group. CONCLUSIONS These results contribute to a growing literature implicating a role for the genu of the CC in BPD and are the first to report WM variations in the AC of children with BPD. Taken together with the correlational data for aggression and the role of the AC in emotional processing, our data provide preliminary evidence for a possible association between the structural integrity of the WM of the AC and aggression in pediatric BPD.
Prognostic Biomarkers for Hodgkin Lymphoma

The prognosis of patients with classical Hodgkin lymphoma following chemo- and radiotherapy has been excellent during the last 4 decades. However, the development of secondary malignancies is of major concern. Therefore, the reduction of radiotherapy application is a major objective of ongoing clinical trials. De-escalation of treatment may increase the risk of relapses and thus may lead to reappearance of prognostic factors. Prognostic biomarkers might help to identify patients who are at increased risk of relapse. This review summarizes the current knowledge about potential prognostic biomarkers for patients with classical Hodgkin lymphoma.
Electron cryomicroscopy structure of N‐ethyl maleimide sensitive factor at 11 Å resolution

N‐ethyl maleimide sensitive factor (NSF) belongs to the AAA family of ATPases and is involved in a number of cellular functions, including vesicle fusion and trafficking of membrane proteins. We present the three‐dimensional structure of the hydrolysis mutant E329Q of NSF complexed with an ATP–ADP mixture at 11 Å resolution by electron cryomicroscopy and single‐particle averaging of NSF·α‐SNAP·SNARE complexes. The NSF domains D1 and D2 form hexameric rings that are arranged in a double‐layered barrel. Our structure is more consistent with an antiparallel orientation of the two rings rather than a parallel one. The crystal structure of the D2 domain of NSF was docked into the EM density map and shows good agreement, including details at the secondary structural level. Six protrusions corresponding to the N domain of NSF (NSF‐N) emerge from the sides of the D1 domain ring. The density corresponding to α‐SNAP and SNAREs is located on the 6‐fold axis of the structure, near the NSF‐N domains. The density of the N domain is weak, suggesting conformational variability in this part of NSF.
Using App Inventor in Introductory CS Courses

Meimei Gao Mercer County Community College Business & Technology Division 1200 Old Trenton Road West Windsor, NJ 08550 gaom@mccc.edu Julie Johnson Vanderbilt University Elec. Eng. & Comp. Sci. Dept. 2301 Vanderbilt Place Nashville, TN 37235 Julie.l. johnson@vanderbilt.edu Dale Reed University of Illinois at Chicago Dept. of Computer Science 851 S. Morgan St. (MC 152) Chicago, IL 60607-7053 reed@uic.edu Cate Sheller Kirkwood Community College Math/Science Dept. 6301 Kirkwood Blvd SW Cedar Rapids, IA 52402 USA Cate.Sheller@kirkwood.edu Franklyn Turbak (Moderator) Wellesley College Computer Science Dept. 136 Central St. Wellesley MA, 02481 fturbak@wellesley.edu
Night temperature has a minimal effect on respiration and growth in rapidly growing plants.

BACKGROUND AND AIMS Carbon gain depends on efficient photosynthesis and adequate respiration. The effect of temperature on photosynthetic efficiency is well understood. In contrast, the temperature response of respiration is based almost entirely on short-term (hours) measurements in mature organisms to develop Q(10) values for maintenance and whole-plant respiration. These Q(10) values are then used to extrapolate across whole life cycles to predict the influence of temperature on plant growth. METHODS In this study, night temperature in young, rapidly growing plant communities was altered from 17 to 34 degrees C for up to 20 d. Day temperature was maintained at 25 degrees C. CO(2) gas-exchange was continuously monitored in ten separate chambers to quantify the effect of night-temperature on respiration, photosynthesis and the efficiency of carbon gain (carbon use efficiency). KEY RESULTS Respiration increased only 20-46 % for each 10 degrees C rise in temperature (total respiratory Q(10) of between 1.2 to about 1.5). This change resulted in only a 2-12 % change in carbon use efficiency, and there was no effect on cumulative carbon gain or dry mass. No acclimation of respiration was observed after 20 d of treatment. CONCLUSIONS These findings indicate that whole-plant respiration of rapidly growing plants has a small sensitivity to temperature, and that the sensitivity does not change among the species tested, even after 20 d of treatment. Finally, the results support respiration models that separate respiration into growth and maintenance components.
Fusion of geometrical and visual information for localization and mapping in outdoor environments

Laser scanners are widely used with mobile robots for simultaneous localization and mapping. The laser data can be used to build a dense map or a feature based map, where the features are extracted from laser scanner (LIDAR) data. On the other hand, diverse approaches exist, which use one or several cameras to extract features from the environment. In this paper, an approach to combine these sensors in a unified framework is proposed. The combination is achieved by fusion of sensor data as well as incorporation of grid and feature based map representations.
Smart Garment to Help Children Improve Posture

Many of the aches and pains of adults are the result not of injuries, but of the long-term effects of distortions in posture or alignment. Postural kyphosis in adolescence may be one of the effects of poor standing and sitting habits. Kyphosis is an excessive rounding of the upper spine. A smart garment that can monitor and provide vibration feedback to children has been developed to investigate an alternative treatment possibility. Laboratory tests verified that the accuracy of the system was plusmn2deg within the full 180deg range. A clinical trial has been conducted and it showed that the system can aid subjects to improve by 20% the proportion of time in a more balanced posture. The long term effect is still under investigation
A scintillating gas detector for 2D dose measurements in clinical carbon beams

A two-dimensional position sensitive dosimetry system based on a scintillating gas detector has been developed for pre-treatment verification of dose distributions in hadron therapy. The dosimetry system consists of a chamber filled with an Ar/CF4 scintillating gas mixture, inside which two cascaded gas electron multipliers (GEMs) are mounted. A GEM is a thin kapton foil with copper cladding structured with a regular pattern of sub-mm holes. The primary electrons, created in the detector's sensitive volume by the incoming beam, drift in an electric field towards the GEMs and undergo gas multiplication in the GEM holes. During this process, photons are emitted by the excited Ar/CF4 gas molecules and detected by a mirror-lens-CCD camera system. Since the amount of emitted light is proportional to the dose deposited in the sensitive volume of the detector by the incoming beam, the intensity distribution of the measured light spot is proportional to the 2D hadron dose distribution. For a measurement of a 3D dose distribution, the scintillating gas detector is mounted at the beam exit side of a water-bellows phantom, whose thickness can be varied in steps. In this work, the energy dependence of the output signal of the scintillating gas detector has been verified in a 250 MeV/u clinical 12C ion beam by means of a depth–dose curve measurement. The underestimation of the measured signal at the Bragg peak depth is only 9% with respect to an air-filled ionization chamber. This is much smaller than the underestimation found for a scintillating Gd2O2S:Tb (‘Lanex’) screen under the same measurement conditions (43%). Consequently, the scintillating gas detector is a promising device for verifying dose distributions in high LET beams, for example to check hadron therapy treatment plans which comprise beams with different energies.
Short communication Antimicrobial activity of some coumarin containing herbal plants growing in Finland

Antimicrobial screening against selected Gram-positive and Gram-negative bacteria, yeasts, mold, as well as plant pathogenic fungi, with emphasis on method optimization was carried out on methanol extracts prepared from seven plants grown in Finland. Sensitivity to the extracts was found to vary considerably among the micro-organisms, the extract from Petroselinum crispum and Ruta gra6eolens showing the highest toxicity against Rhizoctonia solani. The growth of Heterobasidium annosum was inhibited, whereas that of Phytophtora (cactorum) was promoted by all the extracts. The antibacterial and antifungal activities of six natural coumarin compounds were weak, except for the inhibitory effect against Fusarium culmorum. © 2000 Elsevier Science Ireland Ltd. All rights reserved.
A multi-sensor polarimetric analysis over archaeological sites

The goal of the research is to carry out a new methodology for the study and the detection of surface and subsurface archaeological structures in the two UNESCO ancient cities of Gebel Barkal (Sudan) and Samarra (Iraq). The analysis is carried out by means of polarimetric data of two SAR (Synthetic Aperture Radar) sensors: RADARSAT-2 and ALOS-PALSAR. In this paper we present the preliminary results obtained by comparing similar incidence angle of ALOS-PALSAR (23.10° and 26.20°) and RADARSAT-2 (27.07°) images and, subsequently, comparing different incidence angle of RADARSAT-2 data with 27° and 45°, in order to find out the most suitable configuration for the detection of archaeological structures.
Evidence Base Update of Psychosocial Treatments for Child and Adolescent Depression

Depression in youth is prevalent and disabling and tends to presage a chronic and recurrent course of illness and impairment in adulthood. Clinical trial research in youth depression has a 30-year history, and evidence-based treatment reviews appeared in 1998 and 2008. The current review of 42 randomized controlled trials (RCTs) updates these reviews to include RCTs published between 2008 and 2014 (N = 14) and reevaluates previously reviewed literature. Given the growing maturity of the field, this review utilized a stringent set of methodological criteria for trial inclusion, most notable for excluding trials based in subclinical samples of youth that had been included in previous reviews (N = 12) and including well-designed RCTs with null and negative findings (N = 8). Findings from the current review suggest that evidence for child treatments is notably weaker than for adolescent interventions, with no child treatments achieving well-established status and the evidentiary basis of treatments downgraded from previous reports. Cognitive behavioral therapy (CBT) for clinically depressed children appears to be possibly efficacious, with mixed findings across trials. For depressed adolescents, both CBT and interpersonal psychotherapy are well-established interventions, with evidence of efficacy in multiple trials by independent investigative teams. This positive conclusion is tempered by the small size of the interpersonal psychotherapy literature (N = 6) and concern that CBT effects may be attenuated in clinically complicated samples and when compared against active control conditions. Data on predictors, moderators, and mediators are examined and priorities for future research discussed.
Dynamic Phenomena Coupling Analysis and Modeling of Proton Exchange Membrane Fuel Cells

Dynamic variable coupling analysis is an important method to properly design a control structure for complex multivariable and multi-physical dynamic systems, such as fuel cells. The fuel cell is an electrochemical energy conversion device which includes different inter-coupled dynamic phenomena in electrical, fluidic, and thermal domains. In order to achieve optimized fuel cell performance, different operation variables, such as fuel cell temperature, inlet air flow rate, hydrogen pressure, and membrane water content, need to be properly controlled. In this paper, variable coupling analyses of fuel cell dynamic behaviors are presented and discussed based on a proton exchange membrane fuel cell (PEMFC) dynamic model, which considers in particular the transient phenomena in both fluidic and thermal domain. The analyses of dynamic phenomena step responses are conducted using the relative gain array for various control input variables. Quantitative analyses of coupling effects in different physical domains are shown and discussed. The analysis results can be used to optimize the controller design for fuel cell system.
Seguimiento automatizado de variables de control en pacientes crónicos

Un sueno escaso o de mala calidad puede tener repercusiones negativas en la vida diaria. Si esta situacion se prolonga en el tiempo, puede afectar al estado de animo e interferir en el trabajo y la vida social de una persona. Son muchos los factores que determinan la calidad del sueno. No es suficiente con dormir, sino que hay que dormir bien para que el sueno sea realmente reparador y se pueda uno levantar descansado y con energia. Muchos aspectos como la actividad fisica, las comidas y bebidas, los horarios, pueden alterar la calidad del sueno o generar dificultades para conciliarlo por lo que en los ultimos anos han salido al mercado varios dispositivos y aplicaciones cuantificadoras que ayudan a monitorizar el sueno. Existen dispositivos que solamente registran el movimiento y la temperatura corporal y aun asi generan una gran cantidad de datos. Debido a esto, la informacion producida puede no ser facilmente interpretable. En este proyecto usamos un dispositivo de monitorizacion que ofrece mas informacion (como temperatura y flujo termico) por lo que queremos mejorar la interpretabilidad de los datos que se generan para ayudar a facilitar el trabajo de los medicos que las utilizan con sus pacientes intentando descubrir trastornos metabolicos. Se aspira a simplificar el trabajo manual que ahora se realiza intentando que sea mas automatico. Para ello, en este proyecto se utilizan tecnicas de mineria de datos en series temporales que permiten hacer un analisis exploratorio de los datos y agrupar la informacion de forma que los resultados se muestren de una forma resumida y concreta y que pueda ser percibida de un vistazo. Utilizando estas tecnicas creamos una aplicacion que obtiene series temporales de los datos particionadas en distintos tipos de episodios, centrandonos en episodios de sueno y de actividad fisica, clasificando los episodios de sueno por su similitud y presentando un resumen de la actividad del paciente a lo largo de toda la monitorizacion.
Treatment of active Crohn’s disease in children using partial enteral nutrition with liquid formula: a randomised controlled trial

Background and aims: Total enteral nutrition (TEN) with a liquid formula can suppress gut inflammation and induce remission in active Crohn’s disease. The mechanism is obscure. Studies have suggested that long term nutritional supplementation with a liquid formula (partial enteral nutrition (PEN)) may also suppress inflammation and prevent relapse. The aim of this study was to compare PEN with conventional TEN in active Crohn’s disease. Patients and methods: Fifty children with a paediatric Crohn’s disease activity index (PCDAI) >20 were randomly assigned to receive 50% (PEN) or 100% (TEN) of their energy requirement as elemental formula for six weeks. The PEN group was encouraged to eat an unrestricted diet while those receiving TEN were not allowed to eat. The primary outcome was achievement of remission (PCDAI <10). Secondary analyses of changes in erythrocyte sedimentation rate (ESR), C reactive protein, albumin, and platelets were performed to look for evidence of anti-inflammatory effects. Results: Remission rate with PEN was lower than with TEN (15% v 42%; p = 0.035). Although PCDAI fell in both groups (p = 0.001 for both), the reduction was greater with TEN (p = 0.005). Moreover, the fall in PCDAI with PEN was due to symptomatic and nutritional benefits. With both treatments there were significant improvements in relation to abdominal pain, “sense of wellbeing”, and nutritional status. However, only TEN led to a reduction in diarrhoea (p = 0.02), an increase in haemoglobin and albumin, and a fall in platelets and ESR. Conclusions: TEN suppresses inflammation in active Crohn’s disease but PEN does not. This suggests that long term nutritional supplementation, although beneficial to some patients, is unlikely to suppress inflammation and so prevent disease relapse.
Radiosensitivity in Fanconi anaemia: application to the conditioning regimen for bone marrow transplantation

Summary. Fanconi anaemia, an autosomal recessive constitutional aplastic anaemia, seems to be related to a DNA repair mechanism defect. Bone marrow transplantation is the only treatment which can cure these patients. Previous attempts at BMT have shown an increased sensitivity to Cyclophosphamide used for the conditioning. Such a sensitivity has also been observed in vitro when Fanconi anaemia cells were incubated with alkylating agents. We have tested the in vivo radiosensitivity and cell repair after skin contact radiotherapy to calculate the irradiation dose which could be tolerated by FA patients. Eight patients have been tested and the results confirmed the suspected increased radiosensitivity in the majority of patients. Following these results, four patients were conditioned with low dose Cyclophosphamide (20 mg/kg) associated with 5 Grays thoraco‐abdominal irradiation. All had a take and no major complication of the conditioning regimen. All are alive in good condition from day 51 to day 330 after transplant. Oesophagitis was one major unexpected complication. This study confirms the possibility of curing FA patients with BMT when the conditioning regimen is modified according to the pathophysiology of the disease.
Evaluation du traitement visuel précoce des visages chez les usagers de cannabis : étude par potentiels évoqués

Le cannabis est la drogue illegale la plus consommee actuellement en France. Le Δ9-tetrahydrocannabinol (Δ9-THC), en tant qu’excocannabinoide, a un impact sur le systeme visuel via le systeme endocannabinoide. Physiologiquement, parmi les deux voies majoritairement responsables de la transmission de l’information visuelle aux stades les plus precoces, la voie magnocellulaire pourrait etre la plus sensible a l’effet du Δ9-THC. La perception des visages, stimuli complexes, necessite le traitement precoce d’informations de bas niveaux : les frequences spatiales. Or, les differentes gammes de frequences spatiales, separables en gamme de basses (BFS) et de hautes frequences spatiales (HFS) seraient respectivement transmises de maniere privilegiee par les voies magnocellulaire et parvocellulaire. Par ailleurs, la litterature fait etat d’anomalies du traitement magnocellulaire dans la schizophrenie, une pathologie dont le risque accroit avec l’usage de cannabis. Ainsi, par le concours d’etudes chez des usagers de cannabis, des personnes souffrant de schizophrenie et des volontaires sains, notre recherche devait permettre d’evaluer l’impact de l’usage de cannabis sur les processus sensoriels et perceptifs en jeu dans le traitement des visages. Grâce a la mesure des composantes des potentiels evoques P100 et N170 en reponse aux differentes gammes de frequences spatiales contenues dans les visages, nous validons dans une premiere etude la methodologie utilisee, confirmant notamment la sensibilite de la composante P100 aux BFS et de la N170 aux HFS. Une deuxieme etude utilisant la meme methodologie suggere une alteration du traitement des informations de BFS chez les consommateurs de cannabis, mesurable par une alteration de l’etape perceptive d’integration des informations de bas niveau associee a la N170. Une troisieme etude portant sur des patients souffrant de schizophrenie retrouve une alteration du traitement des BFS au cours des etapes precoces (composantes P100 et N170) et permet d’interpreter les resultats observes chez les usagers de cannabis sur la base d’une pathologie dont les dysfonctions visuelles sont mieux connues.
Exercise in the rehabilitation from cancer.

even patients who are undergoing treatment for cancer or who are recovering from cancer treatment. However, this was not always obvious. In 1988, Meryl Winningham rocked the cancer community with her groundbreaking series of studies of women undergoing chemotherapy for breast cancer. Women who were randomized to a bicycle exercise group experienced less chemotherapy-induced nausea (Winningham & MacVicar, 1988), increased their functional capacity (MacVicar, Winningham, & Nickel, 1989), and increased their lean muscle tissue (Winningham, MacVicar, Bondoc, Anderson, & Minton, 1989) both over time and as compared to nonexercise control groups. What was so revolutionary 18 years ago seems so obvious today. In a growing body of research that has investigated exercise in patients with cancer, dramatic improvements in physiological and psychological functioning have been documented in patients participating in aerobic exercise programs. Over 150 studies have been published showing the nearly universal benefits of exercise in this patient population (Courneya, 2001, 2003; Courneya & Friedenreich, 1999; Fairey, Courneya, Field, & Mackey, 2002; Friedenreich & Courneya, 1996; Galvão & Newton, 2005; Knols, Aaronson, Uebelhart, Fransen, &