Miracle-dz/UniFAR-FTUs huggingface dataset:
Measuring Method and Empirical Study on Public Willingness-to-pay for Environmental Conservation under Spatial Scale

In view of the fact that there're spatial differences in Willingness-to-pay (WTP) among the public, it is of great significance to explore the Contingent Valuation Method (CVM) by distance under spatial scale to solve the problem of cost sharing of environmental management. This paper constructs the spatial lag model of WTP and discusses the spatial interaction relationship of WTP in combination of Moran’s I Index and spatial partitioned effects, which remedies the deficiency of traditional CVM model in spatial effects analysis. Based on the characteristics that double-bounded dichotomous choice CVM data is interval data, the probability utility function is used to propose the parameter estimation method for the spatial lag model of WTP. Songhua River is taken as an example to make empirical analysis, the results indicate: (1) The spatial lag model of WTP is effective to deal with the data of dichotomous choice CVM in spatial scale. (2) There’re distance decay effects of WTP under different spatial scales and the degree of public recognition is the main motivation affecting the decay. (3) The ecological value of the Songhua River in 2012 is 8.315 billion CNY. The research provides a new approach for CVM to evaluate the resource and environmental value and enhances the scientificity and effectiveness of the results with CVM evaluation method.
Plasma monocyte chemoattractant protein-1 as risk marker in type 2 diabetes mellitus and coronary artery disease in North Indians

The chemokine monocyte chemoattractant protein-1 (MCP-1) is implicated in chronic inflammation, insulin resistance and atherosclerosis. The present study was designed to explore the relation of plasma levels of MCP-1 to disease pathology in type 2 diabetes and coronary artery disease (CAD) patients. Fasting plasma venous samples were taken from 162 subjects divided into four groups: Patients with type 2 diabetes mellitus and CAD (n=41), type 2 diabetes patients without CAD (n=50), CAD patients with no history of diabetes (n=41) and healthy controls (n=30). Coronary risk factors such as body mass index, percentage body fat, waist/hip ratio, blood pressure and physical activity were measured using standard procedures. Plasma MCP-1 was quantitatively estimated by sandwich enzyme-linked immunoabsorbent assay (ELISA). Significant differences were observed for MCP-1 levels, percent body fat, body mass index, waist/hip ratio, systolic and diastolic blood pressure amongst the groups. MCP-1 concentration was significantly correlated with diabetes duration (p<0.001), body mass index (p<0.01), waist/hip ratio (p<0.01), systolic blood pressure (p<0.01), percentage body fat (p<0.01) and physical activity level (p<0.001). MCP-1 might serve as a marker for CAD, and its association with CAD is mainly driven by traditional coronary risk factors.
Histatin 5-Spermidine Conjugates Have Enhanced Fungicidal Activity and Efficacy as a Topical Therapeutic for Oral Candidiasis

ABSTRACT Oropharyngeal candidiasis (OPC) is caused by the opportunistic fungi Candida albicans and is prevalent in immunocompromised patients, individuals with dry mouth, or patients with prolonged antibiotic therapies that reduce oral commensal bacteria. Human salivary histatins, including histatin 5 (Hst 5), are small cationic proteins that are the major source of fungicidal activity of saliva. However, Hsts are rapidly degraded in vivo, limiting their usefulness as therapeutic agents despite their lack of toxicity. We constructed a conjugate peptide using spermidine (Spd) linked to the active fragment of Hst 5 (Hst 54–15), based upon our findings that C. albicans spermidine transporters are required for Hst 5 uptake and fungicidal activity. We found that Hst 54–15-Spd was significantly more effective in killing C. albicans and Candida glabrata than Hst 5 alone in both planktonic and biofilm growth and that Hst 54–15-Spd retained high activity in both serum and saliva. Hst 54–15-Spd was not bactericidal against streptococcal oral commensal bacteria and had no hemolytic activity. We tested the effectiveness of Hst 54–15-Spd in vivo by topical application to tongue surfaces of immunocompromised mice with OPC. Mice treated with Hst 54–15-Spd had significant clearance of candidal tongue lesions macroscopically, which was confirmed by a 3- to 5-log fold reduction of C. albicans colonies recovered from tongue tissues. Hst 54–15-Spd conjugates are a new class of peptide-based drugs with high selectivity for fungi and potential as topical therapeutic agents for oral candidiasis.
The brain in the belly: What and how of fetal neuroimaging?

This work reviews magnetic resonance imaging in the developing human brain. It focuses on fetal brain imaged in vivo and in utero with complementary sections on abnormalities seen in clinical settings, and on potential of diffusion tensor imaging and of proton magnetic resonance spectroscopy. The main purposes are to illustrate the normal fetal developing brain and its abnormalities commonly encountered in utero, and to emphasize the potential role of adjunct techniques such as diffusion imaging and spectroscopy that may help elucidate fetal brain maturation and its abnormalities. J. Magn. Reson. Imaging 2012;36:788–804. © 2012 Wiley Periodicals, Inc.
Flexfly: Enabling a Reconfigurable Dragonfly through Silicon Photonics

The Dragonfly topology provides low-diameter connectivity for high-performance computing with all-to-all global links at the inter-group level. Our traffic matrix characterization of various scientific applications shows consistent mismatch between the imbalanced group-to-group traffic and the uniform global bandwidth allocation of Dragonfly. Though adaptive routing has been proposed to utilize bandwidth of non-minimal paths, increased hops and cross-group interference lower efficiency. This work presents a photonic architecture, Flexfly, which “trades” global links among groups using low-radix Silicon photonic switches. With transparent optical switching, Flexfly reconfigures the inter-group topology based on traffic pattern, stealing additional direct bandwidth for communication-intensive group pairs. Simulations with applications such as GTC, Nekbone and LULESH show up to 1.8× speedup over Dragonfly paired with UGAL routing, along with halved hop count and latency for cross-group messages. We built a 32-node Flexfly prototype using a Silicon photonic switch connecting four groups and demonstrated 820 ns interconnect reconfiguration time.
Conservation of tRNA mimicry in the 5′-untranslated region of distinct HIV-1 subtypes

Human tRNALys3 serves as the primer for reverse transcription in human immunodeficiency virus type-1 (HIV-1) and anneals to the complementary primer binding site (PBS) in the genome. All tRNALys isoacceptors interact with human lysyl-tRNA synthetase (hLysRS) and are selectively packaged into virions. tRNALys3 must be released from hLysRS in order to anneal to the PBS, and this process is proposed to be facilitated by the interaction of hLysRS with a tRNA-like element (TLE) first identified in the HIV-1 5′-untranslated region (5′-UTR) of the subtype B NL4-3 virus. However, a significant subset of HIV-1 strains represented by the MAL isolate possess a different secondary structure in this region of the genome. Thus, to establish the conservation of this mechanism for primer targeting and release, we investigated the subtype A-like 5′-UTR of the MAL isolate. hLysRS bound to a 229-nt MAL RNA containing the PBS domain with high affinity (Kd = 47 nM), and to a 98-nt truncated construct with ∼10-fold reduced affinity. These results resemble previous studies using analogous NL4-3-derived RNAs. However, in contrast to studies with NL4-3, no binding was observed to smaller stem–loop elements within the MAL PBS domain. The tertiary structure of the 98-nt construct was analyzed using small-angle X-ray scattering, revealing remarkable global structural similarity to the corresponding NL4-3 PBS/TLE region. These results suggest that the tRNA-like structure within the 5′-UTR is conserved across distinct HIV-1 subtypes and that hLysRS recognition of the MAL isolate is likely not conferred by specific sequence elements but by 3D structure.
Regulation of NKCC2 splicing and phosphorylation

Purpose of reviewTransepithelial salt transport in the thick ascending limb of Henle's loop (TAL) crucially depends on the activity of the Na/K/2Cl cotransporter NKCC2. The pharmacologic blockade of NKCC2 leads to pronounced natriuresis and diuresis, which indicate key roles for NKCC2 in renal salt retrieval. The inadequate regulation of NKCC2 and the loss of NKCC2 function are associated with the disruption of salt and water homoeostasis. This review provides a specific overview of our current knowledge with respect to the regulation of NKCC2 by differential splicing and phosphorylation. Recent findingsSeveral mechanisms have evolved to adapt NKCC2 transport to reabsorptive needs. These mechanisms include the regulation of NKCC2 gene expression, the differential splicing of the NKCC2 pre-mRNA, the membrane trafficking, and the modulation of the specific transport activity. Substantial progress has been made over the past few years in deciphering the function of kinases in the regulatory network controlling NKCC2 activity and in elucidating the underlying mechanism and the functional consequences of the regulated differential splicing of the NKCC2 pre-mRNA. SummaryNKCC2 differential splicing and phosphorylation are critically involved in the modulation of the thick ascending limb of Henle's loop reabsorptive capacity and, consequently, in salt homoeostasis, volume regulation, and blood pressure control.
Association of Sexual Abuse With Incident High-Risk Human Papillomavirus Infection Among Young African-American Women

Background: Genital human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. Noticeably absent from the known risk factors for HPV infection is history of sexual abuse. The current study examined the association between sexual abuse and incident high-risk HPV among young adult black women. Methods: This longitudinal study was part of a larger HIV/STI randomized controlled behavioral trial that randomly recruited eligible participants from October 2002 through March 2006. At baseline and 12-month follow-up, 665 black women, aged between 18 and 29, completed a survey assessing known HPV risk factors and history of sexual abuse, and provided specimens that were assayed for high-risk HPV. Incident high-risk HPV infection was defined as a laboratory-confirmed test for high-risk HPV at 12-month follow-up after testing HPV-negative at baseline. Results: The prevalence of high-risk HPV was 38.9%. Age-stratified multiple regression analyses examined sexual abuse that occurred during the 12-month follow-up and acquisition of high-risk HPV; known risk factors for HPV were entered as covariates. Women aged between 18 and 24 with a history of sexual abuse in the past year, compared with participants without a history, were 4.5 times more likely to test positive for an incident high-risk HPV infection (P <0.007). This relationship was not significant for the overall sample or for women aged between 25 and 29 years. Discussion: This is one of the first analyses demonstrating exposure to sexual abuse as a predictor of high-risk HPV. HPV vaccination recommendations for black women, 18 to 24 years of age, with a history of sexual abuse warrant special consideration.
A haplotype of the methylenetetrahydrofolate reductase gene predicts poor tumor response in rectal cancer patients receiving preoperative chemoradiation

Objective The objective of the present study was to evaluate whether germline methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms as well as polymorphisms in the thymidylate synthase gene promoter, namely the variable number tandem repeat polymorphism (TS VNTR) and the intrarepeat G to C single nucleotide polymorphism (TS SNP), are predictive markers of tumor regression in rectal cancer patients following preoperative chemoradiotherapy. Basic methods Blood samples from 125 patients with primary adenocarcinoma of the mid–low rectum who received 5-fluorouracil-based chemotherapy and external beam radiotherapy (median dose 48.4 Gy), 125 patients (women n=45, men n=80; median age 60 years, range 31–79 years) were genotyped. Response to preoperative treatment was evaluated employing the Tumor Regression Grade criteria. On the basis of the pathologic response, patients were classified as responders (TRG 1–2, n=48) and non-responders (TRG 3–5, n=74). Three patients were excluded because of insufficient data. Main results Among the polymorphic variants examined, the MTHFR 677T-1298A haplotype was, upon univariate analysis, the only variable found associated with tumor regression (P=0.004). Moreover, at multivariate analysis, the MTHFR 677T-1298A haplotype was an independent predictor of tumor regression. Patients not carrying the MTHFR 677T-1298A haplotype (odds ratio 0.29, 95% confidence interval 0.13–0.64, P=0.002) displayed a higher response rate than patients with the MTHFR 677T-1298A haplotype. Conclusions Unlike TS VNTR and SNP polymorphisms, MTHFR 677T-1298A haplotype in genomic DNA has the potential to be a predictive marker of tumor response in rectal cancer patients submitted to preoperative chemoradiotherapy
Exploring the built environment, physical activity and related behaviours of young people attending school, college and those not in employment.

BACKGROUND Evidence suggests that environments impact behaviour, including physical activity (PA). The aim was to understand where young people are physically active and the environmental contexts to their activity. To explore how they perceived both barriers to, and enablers for, PA in their environment. METHODS Focus groups were conducted with five groups aged 16-20 years (n = 42; 29 male, 13 female) in Newcastle-upon-Tyne, England between November 2006 and June 2007. Analysis was an iterative process of looking for broad themes and subthemes across the transcripts. RESULTS Themes explored included their main environment; perceptions of their environment; PA and where they are active; activity in the past and safety concerns. Emergent themes included working and PA, transport and activity, limitations of the environment to PA and gender differences. Our results suggest PA was distributed across a range of environments, rather than focused in one locale, or setting. CONCLUSIONS Obesity in young people is a major concern and prevention of obesity a high priority. Little is known about the PA behaviours of this age group and the context of these behaviours during this period of transition. Understanding lifestyle behaviours such as PA and context of activity is an important first step in development interventions to encourage greater activity in this transitory age group.
Consumers’ Perceptions About and Use of the Internet for Personal Health Records and Health Information Exchange: Analysis of the 2007 Health Information National Trends Survey

Background Personal health records (PHRs) and the sharing of health information through health information exchange (HIE) have been advocated as key new components in the effective delivery of modern health care. It is important to understand consumer attitudes toward utilization of PHRs and HIE to evaluate the public’s willingness to adopt these new health care tools. Objective The purpose of this study was to examine consumer attitudes toward PHRs and their health care providers’ use of HIE, as well as to evaluate consumer use of the Internet for tracking PHRs. Methods Analysis of data from the 2007 iteration of the Health Information National Trends Study (HINTS, N=7674) was conducted using multivariate logistic regression to identify predictors of consumer (1) appraisal of PHRs, (2) appraisal of health care provider use of HIE, and (3) use of the Internet for tracking PHRs. Results : Approximately 86% of US adults rated electronic access to their PHRs as important. However, only 9% of them used the Internet for tracking PHRs. Those who rated electronic access to their PHRs as important were more likely to be Hispanic (odds ratio [OR] = 1.34, 95% confidence interval [CI] 1.04 - 1.72) and Internet users (OR = 1.27, 95% CI = 1.02 - 1.57) and less likely to be age 65 and above (OR = 0.50, 95% CI = 0.38 - 0.67) or individuals whose doctors always ensured their understanding of their health (OR = 0.62, 95% CI = 0.49 – 0.78). Those who rated HIE as important were more likely to be 45 to 54 years of age (OR = 1.46, 95% CI = 1.03 - 2.08), 55 to 64 years of age (OR = 1.83, 95% CI = 1.32 - 2.53), or 65 and above (OR = 1.76, 95% CI = 1.27 - 2.43) and less likely to be women (OR = 0.80, 95% CI = 0.68 - 0.95) or individuals who perceive their health information as not safely guarded by their doctors (OR = 0.53, 95% CI = 0.40 - 0.69). Among Internet users, those who used the Internet to track their PHRs were more likely to be college graduates (OR = 1.84, 95% = 1.32 - 2.59) or to have completed some college courses (OR = 1.46, 95% CI = 1.02 - 2.11), to be Hispanic (OR = 1.92, 95% CI = 1.23 - 2.98), or to be individuals with health care provider access (OR = 1.90, 95% CI = 1.21 - 2.97). Women were less likely to use the Internet for tracking PHRs than men (OR = 0.78, 95% CI = 0.61 - 1.00). Conclusions Despite widespread positive appraisal of electronic access to PHRs as important, Internet use for tracking PHRs remains uncommon. To promote PHR adoption, the digital divide associated with the gap in health literacy must be improved, and cultural issues and the doctor-patient relationship need to be studied. Further work also needs to address consumer concerns regarding the security of HIE.
An Outline of a Generalization — started by E. Sparre Andersen — of the classical Ruin Theory

E. Sparre Andersen [1]) presented to the XVth International Congress of Actuaries, New York, 1957, a model of a collective risk process with a positive gross risk premium where the epochs of claims formed a renewal process. Let Ψ(u) (where u denotes the original risk reserve) denote the ruin probability in this model. Generalizing the classical result Sparre Andersen deduced the inequality where R is a suitable positive number depending on the distribution function (continuous to the right), P(y), — ∞ < y < ∞, P(o) < 1, for the amounts of claims in case a claim occurs and also depending on the distribution function, K(t), t > o, K(o) = o, for the times between the epochs of successive claims, (The times between the epochs of successive claims, the inter-occurrence times, are assumed to be independent and identically distributed random variables. The time between the starting point and the epoch of the first claim is assumed to be independent of and to have the same distribution function as the inter-occurrence times. The amounts of claims are assumed to be independent of each other and of the epochs of claims and to be identically distributed.)
Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel

The active site of voltage-activated potassium channels is a transmembrane aqueous pore that permits ions to permeate the cell membrane in a rapid yet highly selective manner. A useful probe for the pore of potassium-selective channels is the organic ion tetraethylammonium (TEA), which binds with millimolar affinity to the intracellular opening of the pore and blocks potassium current. In the potassium channel encoded by the Drosophila Shaker gene, an amino acid residue that specifically affects the affinity for intracellular TEA has now been identified by site-directed mutagenesis. This residue is in the middle of a conserved stretch of 18 amino acids that separates two locations that are both near the external opening of the pore. These findings suggest that this conserved region is intimately involved in the formation of the ion conduction pore of voltage-activated potassium channels. Further, a stretch of only eight amino acid residues must traverse 80 percent of the transmembrane electric potential difference.
Government Effectiveness, Middle Class and Poverty in the EU: A Dynamic Multilevel Analysis

Using the 2008-2011 EU-Statistics on Income and Living Conditions data, we implement a dynamic three-level model to analyze poverty persistence in 26 EU countries. Our aim is to understand why an individual experiencing poverty today is much more likely to experience it again. We innovate with respect to the existing literature by disentangling the effects of observed and unobserved heterogeneity at country level on the process that may generate poverty persistence. In particular, after controlling for socio-economic factors, including those related to qualitative and quantitative indicators of the welfare state, we analyze for the first time how the size of the middle class in each country affects current individual risk of poverty and its dynamics. Our findings show that the risk of poverty is negatively related to the quality of government activity to social expenditure and to the size of the middle class. Similarly, we show that the impact of past records on current poverty levels may be stronger (weaker) when institutional quality is low (high). This also indicates that good institutions and satisfactory social expenditure may help reducing the adverse current and future impact of experiencing poverty for any level of per capita income and middle class size. Policy implications are also discussed.
Safety and efficacy of a soluble P75 tumor necrosis factor receptor (Enbrel, etanercept) in patients with advanced heart failure.

BACKGROUND Although previous studies suggested that TNF may contribute to heart failure progression, it is unclear whether antagonizing TNF is beneficial in heart failure patients. METHODS AND RESULTS Eighteen NYHA class III heart failure patients were randomized into a double-blind dose-escalation study to examine the safety and potential efficacy of etanercept, a specific TNF antagonist (Enbrel). Patients received placebo (6 patients) or an escalating dose (1, 4, or 10 mg/m2) of etanercept (12 patients) given as a single intravenous infusion. Safety parameters and patient functional status were assessed at baseline and at days 1, 2, 7, and 14. There were no significant side effects or clinically significant changes in laboratory indices. There was, however, a decrease in TNF bioactivity and a significant overall increase in quality-of-life scores, 6-minute walk distance, and ejection fraction in the cohort that received 4 or 10 mg/m2 of etanercept; there was no significant change in these parameters in the placebo group. CONCLUSIONS A single intravenous infusion of etanercept was safe and well tolerated in patients with NYHA class III heart failure. These studies provide provisional evidence that suggests that etanercept is sufficient to lower levels of biologically active TNF and may lead to improvement in the functional status of patients with heart failure.
Design and testing of a low-cost electromyogram that uses a right leg driver circuit

This paper presents the design and testing of a low cost ($30 unisolated, $75 isolated) electromyogram (EMG) circuit. The circuit is designed to utilise a Right Leg Driver (RLD) circuit: the RLD removes coupled electromagnetic interference from the subject. The benefit inherent with the use of the RLD is that it removes interference in real time, without attenuating the bio-potential signal. The circuit has been successfully tested to record bio-potential signals from multiple able-bodied subjects. A signal recorded from one subject's bicep brachii during an isometric contraction had a SNR of 57.8 dB.