Miracle-dz/UniFAR-FTUs huggingface dataset:
Lymphoma Cells in Patients Undergoing Transplantation for AIDS-Related + Modified CD 34 − RNA-Based Gene Therapy for HIV with Lentiviral Vector

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Opsonizing and Bactericidal Activity of Antibodies Against Common Antigen of Enterobacteriaceae

Domingue, Gerald J. (State University of New York at Buffalo, Buffalo, N.Y.), and Erwin Neter. Opsonizing and bactericidal activity of antibodies against common antigen of Enterobacteriaceae. J. Bacteriol. 91:129–133. 1966. —In addition to the well-known O, H, K, and Vi antigens, Enterobacteriaceae produce a common antigen, which was first identified by hemagglutination tests with Escherichia coli O14 antiserum. Studies on the biological significance of this antigen by in vitro phagocytic experiments have revealed that opsonization is markedly enhanced in the presence of the corresponding antibody, rabbit polymorphonuclear leukocytes, and normal rabbit serum. This effect is specific, because Pseudomonas aeruginosa, which is devoid of this antigen, is not opsonized under these conditions, and removal of the antibody by absorption markedly reduces the uptake of enteric bacteria containing the antigen. Opsonization thus represents another method for the study of this antigen-antibody system. Bactericidal tests have revealed that antibodies against this antigen, engendered in rabbits by different strains of enteric bacteria and various procedures, are bactericidal for E. coli O14 but not for other enteric bacteria, possibly due to previously demonstrated differences between the antigen moieties obtained from these microorganisms.
Quality of primary care in England with the introduction of pay for performance.

In 2004, the United Kingdom invested $3.2 billion in a new program to reward general practitioners for the delivery of high-quality care. The authors examine longitudinal data on quality and report that the incentive program may have prompted a modest improvement in the quality of care for two of the three chronic conditions they studied.
Cancer incidence of workers in the Swedish petroleum industry.

OBJECTIVES: To estimate the risk of cancer due to occupational exposure to petroleum products in the Swedish transport and refinery industries. METHODS: In a retrospective cohort study the cancer incidence in 4128 men and 191 women, who had worked for at least one year in the petroleum industry, was compared with the incidence in the general population. The job titles and employment times for each person were found in personal files in the industries. The men had on average worked in jobs exposed to petroleum for 11.6 years at the end of the observation period. The cases of cancer were identified by record linkage with the Swedish cancer register. RESULTS: In total there were 146 cases of cancer v 157.6 expected (standardised mortality ratio (SMR) 0.93 90% confidence interval (90% CI) 0.80 to 1.1). Operators at refineries had an increased risk of leukaemia (6 cases v 1.7 expected, 90% CI of relative risk (RR) 1.5 to 7.0). Five of the six cases had started to work at the refineries in the 1950s or later. No other significantly increased risk of cancer was found. Distribution workers had a decreased incidence of lung cancer (no cases, 90% CI of RR 0 to 0.4). CONCLUSIONS: Operators at Swedish refineries had an increased risk of leukaemia. A possible cause is exposure to benzene. There was no increased risk of leukaemia in distribution workers. Distribution workers had a decreased risk of lung cancer.
24-h esophageal pH testing in asthmatics: respiratory symptom correlation with esophageal acid events.

BACKGROUND Gastroesophageal reflux (GER) may be a trigger for asthma and may be clinically silent. Twenty-four-hour esophageal pH testing accurately diagnoses GER in asthmatics. There are no reports correlating respiratory symptoms with esophageal acid events. This study examines the prevalence and severity of GER in asthmatics with and without reflux symptoms and examines respiratory symptom correlation with esophageal acid. METHODS All esophageal manometry and 24-h esophageal pH tests performed were reviewed in asthmatics who met entrance criteria from July 1, 1989, through November 1, 1994. GER was present if esophageal pH tests were abnormal. Results of esophageal tests were compared for asthmatics with reflux symptoms and GER and asthmatics without reflux symptoms and GER. Respiratory symptoms correlated with esophageal acid events if the esophageal pH was < 4 simultaneously with the respiratory event or within 5 min before its onset. RESULTS Of 199 asthmatics who qualified for analysis, 164 (82%) had reflux symptoms. The results of 24-h esophageal pH tests were abnormal in 118 of 164 asthmatics with reflux symptoms (72%), compared with 10 of 35 asthmatics without reflux symptoms (29%). Among asthmatics with GER, 119 of 151 respiratory symptoms (78.8%) were associated with esophageal acid. Seventy-six of 84 reported coughs (90.5%) were associated with esophageal acid. Theophylline did not alter esophageal parameters. CONCLUSIONS There is a strong correlation between esophageal acid events and respiratory symptoms in asthmatics with GER. Respiratory symptom correlation with esophageal acid events further supports that GER may be a trigger for asthma.
Estimation of the net energy requirement for maintenance in broilers

Objective The net energy requirement for the maintenance (NEm) of broilers was determined using regression models by the indirect calorimetry method (ICM) or the comparative slaughter method (CSM). Methods A 2×4 factorial arrangement of treatments including the evaluation method (ICM or CSM) and feed intake (25%, 50%, 75%, or 100% of ad libitum recommended) was employed in this experiment. In the ICM, 96 male Arbor Acres (AA) birds aged d 15 were used with 4 birds per replicate and 6 replicates in each treatment. In the CSM, 116 male AA birds aged d 15 were used. Among these 116 birds, 20 were selected as for initial data and 96 were assigned to 4 treatments with 6 replicate cages and 4 birds each. The linear regression between retained energy (RE) and metabolizable energy intake (MEI) or the logarithmic regression between heat production (HP) and MEI were used to calculate the metabolizable or net energy requirement for maintenance (MEm) or NEm, respectively. Results The evaluation method did not detect any differences in the metabolizable energy (ME), net energy (NE), and NE:ME of diet, and in the MEI, HP, and RE of broilers. The MEI, HP, and RE of broilers decreased (p<0.01) as the feed intake decreased. No evaluation method× feed intake interaction was observed on these parameters. The MEm and NEm estimated from the linear relationship were 594 and 386 kJ/kg of body weight (BW)0.75/d in the ICM, and 618 and 404 kJ/kg of BW0.75/d in the CSM, respectively. The MEm and NEm estimated by logarithmic regression were 607 and 448 kJ/kg of BW0.75/d in the ICM, and were 619 and 462 kJ/kg of BW0.75/d in the CSM, respectively. Conclusion The NEm values obtained in this study provide references for estimating the NE values of broiler diets.
Risk of Coronary Heart Disease in Men With Poor Emotional Control: A Prospective Study

Objective Many psychosocial factors have been associated with coronary heart disease (CHD), including hostility, anger, and depression. We tested the hypothesis that these factors may have their basis in emotion regulation abilities. Our aim was to determine whether poor emotional control predicted long-term risk of CHD. Methods This Swedish national study includes 46,393 men who were conscripted for military service in 1969 and 1970. The men were aged 18 to 20 years at the time of conscription. Psychologists used a brief semistructured interview to retrospectively assess the conscripts' level of emotional control in childhood and adolescence. The outcome measure was a first fatal or nonfatal event of CHD. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for poor and adequate versus good emotional control. Results After 38 years of follow-up (1971–2009), 2456 incident cases of CHD had occurred. Poor emotional control increased the risk of CHD (HR = 1.31, 95% CI = 1.18–1.45), adjusting for childhood socioeconomic position, anxiety, depression, and parental history of CHD. Further adjustment for life-style–related factors, for example, smoking and body mass index, attenuated the HR to 1.08 (95% CI = 0.97–1.21). In stratified analyses, the fully adjusted association between poor emotional control with CHD remained significantly elevated among men with a parental history of CHD (HR = 1.49, 95% CI = 1.11–2.01, p interaction = .037). Conclusions In the overall study population, poor emotional control had no direct effect on CHD beyond life-style–related factors. However, in men with a parental history of CHD, poor emotional control in adolescence remained significantly predictive of long-term CHD risk even when adjusting for life-style–related factors.
LTE Wireless Network Virtualization: Dynamic Slicing via Flexible Scheduling

The successful virtualization of wireless access networks is strongly affected by the way in which radio resources are managed. The Infrastructure Provider (InP) is required to deploy efficient and flexible scheduling techniques to dynamically allocate the resources for the users associated with different Service Providers (SPs). Service contracts with different SPs and fairness among their users are crucial to the success of the virtualization scheme deployed by the InP. In this paper we develop an efficient resource allocation scheme to allocate the radio resource blocks in LTE networks. The scheme keeps track of the service contracts with the SPs and also the fairness requirements between cell-center users and cell-edge users. Also the scheme allows the flexible definition of fairness requirements for different SPs. The performance of the proposed schemes is evaluated and the results show that the proposed low-complexity scheme is very efficient in terms of computation time and its performance in terms of sum rate is close to the results due to the relaxed solution and coordinate search algorithm.
Where to Position Clozapine: Re-Examining the Evidence

Objective: To review clozapine's position in treatment algorithms for schizophrenia. Method: Clozapine's status is reviewed in the context of its initial discovery and unique clinical and (or) pharmacological profile, withdrawal and link with hematologic concerns, reintroduction with monitoring guidelines, prototype for atypicality, positioning in treatment algorithms, and current evidence regarding efficacy, effectiveness, and side effects. Results: The hematologic monitoring implemented with clozapine's reintroduction here in North America has proven successful in preventing clozapine-related deaths secondary to agranulocytosis. While its other side effects are not without concern, present evidence does not link clozapine to increased mortality rates; indeed, it appears better than other antipsychotics in this regard. Moreover, its clinical superiority compared with all other antipsychotics has been confirmed both in efficacy and in effectiveness trials. Conclusions: Schizophrenia continues to represent a treatment challenge, with many people demonstrating suboptimal response and poor functional outcome. Clozapine is routinely positioned as a third-line treatment in schizophrenia, but in light of existing evidence this warrants re-examination.
SPLIN: Una heramienta para el diseño, ejecución y evaluación de problemas de planificación

Resumen. Este trabajo presenta el diseño e implementación de un Sistema de PLanificación INteligente (SPLIN) que se compone de dos módulos principales: un compilador para el lenguaje de planificación y un Planificador de Orden Parcial (POP). SPLIN está integramente desarrollado en C, dispone de un lenguaje de planificación de fácil utilización e incorpora la técnica de menor compromiso (least commitment) [Weld94] tanto en la ordenación de pasos durante el desarrollo del plan como en el tratamiento de variables. Este último aspecto permite obtener resultados altamente satisfactorios frente a otros planificadores de orden parcial. La versión de SPLIN que se presenta en este artículo es un primer prototipo que se ha realizado en el grupo GTI-IA de la Universidad Politécnica de Valencia.
[Anti-microRNA-221 enhances radiosensitivity of colorectal carcinoma cells by up-regulating PTEN].

OBJECTIVE To investigate the effect of knocking-down microRNA-221 (miR-221) expression on the radiosensitivity of human colorectal carcinoma cells. METHODS Human colorectal carcinoma-derived cell line Caco2 was transfected with miR-221 antisense oligonucleotides (anti-miR-221) via Lipofectamine 2000. Real-time quantitative PCR was performed to detect the expression of miR-221 and PTEN mRNA in Caco2 cells. The changes in the protein expression of PTEN in the transfected cells were detected by Western blotting. The cell death after transfection and irradiation was detected by flow cytometry. RESULTS Transfection with anti-miR-221 caused a significant reduction in miR-221 expression (P<0.05) and up-regulated PTEN protein expression (P<0.05) in Caco2 cells. The percentage of cell death was significantly increased in anti-miR-221 group and anti-miR-221 with irradiation group (P<0.01). Anti-miR-221 significantly enhanced the radiosensitivity of Caco2 cells, which was partially reversed by PTEN-siRNA. CONCLUSION Anti-miR-221 can enhance the radiosensitivity of colorectal carcinoma cells by up-regulating the expression of PTEN.
Neuroimaging of decoding and language comprehension in young very low birth weight (VLBW) adolescents: Indications for compensatory mechanisms

In preterm children with very low birth weight (VLBW ≤ 1500 g), reading problems are often observed. Reading comprehension is dependent on word decoding and language comprehension. We investigated neural activation–within brain regions important for reading–related to components of reading comprehension in young VLBW adolescents in direct comparison to normal birth weight (NBW) term-born peers, with the use of functional magnetic resonance imaging (fMRI). We hypothesized that the decoding mechanisms will be affected by VLBW, and expect to see increased neural activity for VLBW which may be modulated by task performance and cognitive ability. The study investigated 13 (11 included in fMRI) young adolescents (ages 12 to 14 years) born preterm with VLBW and in 13 NBW controls (ages 12–14 years) for performance on the Block Design and Vocabulary subtests of the Wechsler Intelligence Scale for Children; and for semantic, orthographic, and phonological processing during an fMRI paradigm. The VLBW group showed increased phonological activation in left inferior frontal gyrus, decreased orthographic activation in right supramarginal gyrus, and decreased semantic activation in left inferior frontal gyrus. Block Design was related to altered right-hemispheric activation, and VLBW showed lower WISC Block Design scores. Left angular gyrus showed activation increase specific for VLBW with high accuracy on the semantic test. Young VLBW adolescents showed no accuracy and reaction time performance differences on our fMRI language tasks, but they did exhibit altered neural activation during these tasks. This altered activation for VLBW was observed as increased activation during phonological decoding, and as mainly decreased activation during orthographic and semantic processing. Correlations of neural activation with accuracy on the semantic fMRI task and with decreased WISC Block Design performance were specific for the VLBW group. Together, results suggest compensatory mechanisms by recruiting additional brain regions upon altered neural development of decoding for VLBW.
Accessing the purity of a single photon by the width of the Hong–Ou–Mandel interference

We demonstrate a method for determining the spectral purity of single photons. The technique is based on the Hong–Ou–Mandel (HOM) interference between a single-photon state and a suitably prepared coherent field. We show that the temporal width of the HOM dip is related not only to the reciprocal of the spectral width but also to the underlying quantum coherence. Therefore, by measuring the width of both the HOM dip and the spectrum, one can directly quantify the degree of spectral purity. The distinct advantage of our proposal is that it obviates the need for perfect mode matching, since it does not rely on the visibility of the interference. Our method is particularly useful for characterizing the purity of heralded single-photon states.
Do Teacher Unions Hinder Educational Performance?: Lessons Learned from State SAT and ACT Scores

Teacher unions have been demonized by their critics and canonized by their advocates for years, but the actual relationship between teacher unions and educational performance has received very little empirical scrutiny. In this article, Lala Carr Steelman, Brian Powell, and Robert Carini examine the question, "Do teacher unions hinder educational performance? " Focusing on two of the best-known standardized tests, the Scholastic Assessment Test (SAT) and the American College Test (ACT), the authors examine whether interstate variation in standardized test performance is negatively linked to interstate variation in teacher unions. They find a significant and positive relationship: that is, the presence of teacher unions appears to be linked to stronger state performance on these exams. These findings challenge the position that teacher unions depress student academic performance, and in so doing invite further empirical scholarship on this topic from a range of academic disciplines.
Molecular Pathways Molecular Pathways : The Basis for Rational Combination Using MEK Inhibitors in KRAS-Mutant Cancers

Mutations in RAS oncogenes are frequently observed in human cancers, and the mutations result in activation of the RAS–RAF–MEK–ERK pathway, leading to cell proliferation and survival. The pathway is, therefore, a potent therapeutic target in the RAS-mutant cancers. MEK inhibitors can specifically block the pathway and are one of the key types of drugs for the treatment of the RAS-mutant cancers. As RAS proteins activate other downstream signaling proteins in addition to the RAS–RAF–MEK–ERK pathway, combination therapeutic approaches with MEK inhibitors are also being evaluated. Moreover, MEK inhibitors can arrest cancer cells in G1 phase and repress prosurvival Bcl2 family proteins such asMCL1 and BCL2/BCLXL, and increase expression of Bim, a proapoptotic BH3-only family protein. This mechanismmay explain the efficacy of the combination of MEK inhibitors with cytotoxic agents or other targeted inhibitors. A better understanding of the pathway will help us with development of rational combinations for the treatment of the RAS-mutant cancers. Clin Cancer Res; 20(16); 1–7. 2014 AACR.
A progressive interpolation approach for Guruswami-Sudan algorithm

In this paper, we present a progressive interpolation approach in Guruswami-Sudan (GS) decoding of Reed-Solomon (RS) codes. The objective of the interpolation is to construct the minimal polynomial Q(x, y) by the progressive approach with increasing multiplicities until the roots of Q(x, y) give the correct message. Then the error-correction capability can be adaptively obtained by assigning a suitable multiplicity according to the number of errors occurred in the channel. We present an efficient way to update the polynomial set utilizing the previous computational results in the interpolation step. It enables the decoder to adjust its decoding complexity to the needed level. Simulation results suggest that the average decoding complexity of GS algorithm can be significantly reduced by the progressive approach for RS codes.
A Formaldehyde Sensor Based on Molecularly-Imprinted Polymer on a TiO2 Nanotube Array

Today, significant attention has been brought to the development of sensitive, specific, cheap, and reliable sensors for real-time monitoring. Molecular imprinting technology is a versatile and promising technology for practical applications in many areas, particularly chemical sensors. Here, we present a chemical sensor for detecting formaldehyde, a toxic common indoor pollutant gas. Polypyrrole-based molecularly-imprinted polymer (PPy-based MIP) is employed as the sensing recognition layer and synthesized on a titanium dioxide nanotube array (TiO2-NTA) for increasing its surface-to-volume ratio, thereby improving the sensor performance. Our sensor selectively detects formaldehyde in the parts per million (ppm) range at room temperature. It also shows a long-term stability and small fluctuation to humidity variations. These are attributed to the thin fishnet-like structure of the PPy-based MIP on the highly-ordered and vertically-aligned TiO2-NTA.
Molecular characterization of a Campylobacter jejuni 29-kilodalton periplasmic binding protein

Campylobacter jejuni, a gram-negative, microaerophilic, spiral bacterium, is a common cause of human gastrointestinal disease. Although investigators commonly use C. jejuni glycine-hydrochloride extracts in assays to determine the products that promote the binding of the organism to eukaryotic cells, the proteins contained within these extracts remain ill defined. Characterization of these proteins will provide a better understanding of C. jejuni gene regulation and organization. An antiserum was raised against a C. jejuni 29-kDa gel-purified protein detected in glycine-hydrochloride extracts. This antiserum was used to screen an expression library of C. jejuni. A reactive clone that contained an open reading frame of 256 amino acids was identified. The cloned gene was transcribed and translated, and the product was exported to the periplasmic space in Escherichia coli XL1-Blue. The translated C. jejuni product, designated P29, exhibited significant similarity to the histidine and lysine-arginine-ornithine periplasmic binding proteins (HisJ and LAO, respectively) of Salmonella typhimurium. The C. jejuni gene encoding the P29 protein complemented an S. typhimurium HisJ mutant but not a LAO mutant when provided in trans. These data suggest that the C. jejuni gene encoding the P29 protein is a homolog of the S. typhimurium hisJ gene.
What is the cancer risk in Crohn's disease?

P rior studies have established that patients with inflammatory bowel disease (IBD), specifically those with extensive and long-standing ulcerative colitis (UC), have an increased risk of subsequent colorectal cancer. These studies of UC, however, have been based on data from tertiary care settings, primarily in the United States and the United Kingdom. Others, even from similar geographic areas in the US, have shown that the magnitude of this risk may not be so significant.1,2 In addition, others have argued that the risk of cancer is not increased in patients with colitis and data may be further influenced by an underlying baseline risk of colon cancer that is geographically or environmentally influenced, rather than related to IBD per se.3