Miracle-dz/UniFAR-FTUs huggingface dataset:
Jordan: Developing a Model for the Governance of Arab Family Companies and Their Legislation

The current research aimed to developing a model for the governance of Arab family companies and their legislation, which contributes to the interconnection between the vision and the structures of supervision and control, and reduces the conflict and duplication of decision and performance. This is an attempt to address the Problem faced by Arab family companies, namely the ambiguity of roles overlapping tasks, lack of discipline and reflection of family problems on the performance and growth of the company due to the absence of a structure for the governance of these companies. The research used survey methods, and literature review and then the development of indications and opinions and make comparisons and simulations, in order to extract indicators and evidence from them. The research concluded with the development of a model of corporate governance that seeks to unify the components of the various models and their indicators within a single model to avoid defects in these models and gain their advantages and make all practices understandable, easy to implement and review. The research presented a set of recommendation as follows: Testing the model developed in this research and to show its strengths against its weaknesses in preparation for its adoption in the governance of Arab family companies. The need for intensive education on the importance of corporate governance and its necessities. This can be achieved through workshops and seminars. The legal legislator has expanded on the issue of corporate governance and mechanisms for following up on its implementation, and for the urgent need for expansion and clarification. Increasing the financial, moral, and technical support of family companies to ensure their survival continuity and success in supporting the national economy on the one hand and encouraging the establishment of more of these companies on the other. Proposing a course to in universities for the bachelor's and graduate studies entitled "Management of family companies and their governance". Adding an explicit statement on the characteristics of the senior administration and its traits that senior administration has the ability to translate the strategic direction of the company to the actual actions and tangible results, and to mention a text in the Jordanian companies’ law on leadership and creativity.
Measurement of interstitial fluid pressure (IFP) and circulating biomarkers in soft tissue sarcoma (STS): An exploratory phase II clinical and correlative study of sorafenib (SOR) in patients with refractory STS (NCI Protocol 6948).

10091 Background: Interstitial hypertension may contribute to chemo-resistance in STS. Sorafenib is a small molecule tyrosine kinase inhibitor with potent activity against c-RAF/B-RAF, VEGFR-2, and PDGFR-β. By affecting vascular permeability, SOR may potentially reduce IFP. We assessed anti-tumor activity and measured the IFP and circulating biomarkers in patients with superficial refractory STS treated with SOR. Methods: Eligibility criteria included advanced/metastatic STS with no known curative therapy, measurable disease with at least one superficial lesion (>1cm) amenable to biopsy, age ≥18, ECOG performance status ≤2, and no prior SOR therapy. SOR was administered at 400mg BID. IFP measurements were performed intraoperatively as described (Boucher et al 1991); plasma biomarkers were collected pre- and on Day 28 post-SOR. Results: Fifteen patients (median age 59, range 30-84) were enrolled, 14 of whom had prior chemotherapy and/or radiation. Median tumor size was 6.6cm (range 1.3-10.7cm). Common sarc.
CP-063 Assessment of urinary 8-hydroxydeoxyguanosine level in diabetic cancer patients

Background Both diabetes mellitus and cancer are characterised by elevated levels of oxidative stress and the production of free radicals, which further complicates the control and outcomes of these diseases. Purpose To assess the level of urinary 8-hydroxydeoxyguanosine in diabetic cancer patients as a biomarker of both disease progression and chemotherapy administration. Material and methods A controlled prospective observational study was carried out in 100 diabetic patients newly diagnosed with diverse cancer types and eligible for different chemotherapeutic protocols at the oncology unit. Urinary 8-hydroxydeoxyguanosine levels were assessed at baseline (before the required chemotherapy protocol schedule) and at a second reading (at the end of the required chemotherapy protocol schedule). The main outcome measure was urinary 8-hydroxydeoxyguanosine levels as a biomarker of cellular oxidative stress in diabetic patients with cancer. Results There was a significant (p<0.05) increase in urinary 8-hydroxydeoxyguanosine levels between baseline and the second readings (27.04±4.33 ng/dL vs 30.77±4.63 ng/dL), and between the baseline and second readings after a 7 day course (25.96±4.21 ng/dL vs 28.16±5.27 ng/dL), a 14 day course (27.76±5.33 ng/dL vs 31.56±4.47 ng/dL) and a 21 day course (27.22±4.16 ng/dL vs 31.40±4.24 ng/dL). Conclusion The results of this study suggest that oxidative stress based on elevated urinary 8-hydroxydeoxyguanosine levels is related to diabetes mellitus and cancer, which is further boosted during chemotherapy administration. References and/or acknowledgements Great thanks to Assistant Professor Dr Betul Okuyan (Department of Clinical Pharmacy, Faculty of Pharmacy, Marmara University) for guidance and support. No conflict of interest
Residential smart plug with bluetooth communication

Electricity forms the backbone of the modern world but increasing energy demand with the growth of urban areas in recent decades has overwhelmed the current power grid ecosystem. So, there is a need to move towards a more efficient and interconnected smart grid infrastructure. The growing popularity of the Internet of Things(IoT) has increased the demand for smart and connected devices. In this work we developed a hardware device based on the ATmega2560 microcontroller that can estimate the power consumption and control the state of electro-electronic devices interconnected to it through Bluetooth wireless technology. The developed hardware is a smart plug focusing on smart home applications. As a result, by using a smartphone device with Bluetooth communication, one can control and measure electrical parameters of the interconnected electro-electronic hardware such as the RMS (Root Mean Square) current and RMS power been consumed. The obtained results showed the technical viability in the construction of energy consumption measuring device using modules and components available in the Brazilian market.
A transient ionizing radiation SPICE model for PDSOI MOSFET

In this paper, a transient ionizing radiation SPICE model for PDSOI MOSFET is proposed for the simulation of the rail‐span collapse. It is based on the present understanding of transient ionizing radiation effects. The model accounts for the generation and collection of radiation induced transient photocurrent, the influence of the device geometry, and the bias conditions. Verilog‐A behavioral modeling language is utilized to implement the physically based models of the transient current sources, eliminating the use of independent current sources and lumped SPICE element models. The model is validated by comparison with the Sentaurus TCAD simulation results. The comparison of simulation and experimental results of the 64K SRAM fabricated by the 0.13 μm PDSOI technology validates the effectiveness of the dose rate model.
Estimation of construction project building cost by back-propagation neural network

Building cost is an important part of construction projects, and its correct estimation has important guiding significance for the follow-up decision-making of construction units. ,This study focused on the application of back-propagation (BP) neural network in the estimation of building cost. First, the influencing factors of building cost were analyzed. Six factors were selected as input of the estimation model. Then, a BP neural network estimation model was established and trained by ten samples. ,According to the experimental results, it was found that the estimation model converged at about 85 times; compared with radial basis function (RBF), the estimation accuracy of the model was higher, and the average error was 5.54 per cent, showing a good reliability in cost estimation. ,The results of this study provide a reliable basis for investment decision-making in the construction industry and also contribute to the further application of BP neural network in cost estimation.
Possibility of specific expression of the protein toxins at the tumor site with tumor-specialized promoter

The ultimate goal of cancer therapy is to establish a treatment regimen that will ensure complete eradication of cancers with minimal toxicity to the surrounding normal tissues. Protein toxins are highly efficient when they are used as treatment reagents of cancer but are associated with toxicity in normal tissues. Given that specialized promoters have been widely investigated for specific expressions, we speculated that tumor-specialized promoters would play an important role in protein toxin tumor therapy. Therefore, we hypothesize that a tumor-specialized promoter can be inserted into a truncated protein toxin expression vector. Then, the vector can be introduced into the human body by either a viral or nonviral vector. These protein toxin genes would be specifically expressed in tumor cells, but not in normal tissue cells. The proposition may provide a new strategy with the development of protein toxins for specific targeting to neoplastic tumors.
Targeted therapy of acute myeloid leukemia

Advances in the understanding of the genetic underpinnings of acute myeloid leukemia are rapidly being translated into novel treatment strategies. Genomic profiling has highlighted the importance of the epigenetic machinery for leukemogenesis by identifying recurrent somatic mutations involving chromatin-modifier proteins. These genetic alterations function as dynamic regulators of gene expression and involve DNA-methyltransferase 3A, methyltransferase DOT1L, enhancer of zeste homologue 2, isocitrate dehydrogenases 1 and 2 and bromodomain-containing proteins. New therapeutic targets are also emerging from further delineation of cell signaling networks in acute myeloid leukemia blasts mediated by PIM kinases, polo-like kinase 1, cell surface protein CD98 and nucleocytoplasmic shuttling receptors, among others. Early results of targeted therapies directed at these molecular mechanisms are discussed in this review and their potential to improve the outcomes of patients by allowing the use of more effective and less toxic treatments.
Iodinated Contrast-Induced Acute Kidney Injury. Pathophysiology and Prevention

The term acute renal failure (ARF) secondary to ischemic/nephrotoxic injury should no longer be used and be replaced by acute kidney injury (AKI), indicating an abrupt (within 24–48 hours) increase in serum creatinine by 0.5 mg/dL or by 25% above baseline. Replacing “failure” with “injury” served to include the entire range of renal impairment from small changes in serum creatinine to complete loss of renal function. The term ARF should be limited to a decrease in renal function so severe as to require dialysis. When AKI is due to radiographic contrast agents, it is called contrast-induced (CI) AKI. The pathogenesis of CI-AKI is complex and not well known. Many factors are involved, including hemodynamic changes such as renal vasoconstriction, particularly in the outer medulla where tubular segments devoted to active sodium reabsorption are located; the vasoconstriction may be due to direct action of the contrast agent but may also be mediated by stimulation of angiotensin II and adenosine, or by a decrease in the local production of prostaglandins and nitric oxide, all leading to medullary hypoxia. Other factors are osmotic diuresis (with increased tubular reabsorption of sodium and tubular epithelium injury, both worsening medullary hypoxia) and production of reactive oxygen species that will cause endothelial and epithelial damage, likewise worsening medullary hypoxia. The fall in renal blood flow and tubular obstruction will decrease the glomerular filtration rate. Treatment and prevention of CI-AKI are based on opposing these factors by adequate hydration; administration of furosemide along with fluid replacement; theophylline and aminophylline; PGE1 and PGI2; N-acetylcysteine, ascorbic acid and vitamin E; nebivolol and statins.
A Program Evaluation: Therapeutic Playgroupfor Preschool-Aged Children with Mental Health Needs

The understanding of preschool children has been explored in the fields of developmental psychology and early childhood education. The field of school psychology has also increased interest in the assessment of the social and emot ional functioning of preschool children (Martin, 1986). Currently, there are changes in nat io al education policy and societal pressures for systematic, professional assess ment and intervention with younger children (Executive Office of the President, 1990). In addi tion, focus has been placed on the incorporation of evidence-based practices into assessm ent and treatment (Tolan & Dodge, 2005). Mental health services, in particular, aim to address the social and emotional needs of children and families through assessment , effective intervention, and collaboration/consultation. Currently, research in pr eschool programs specifies the use of a developmental model to meet children’s socialemotional needs, physical well-being, motor development, language and literacy development, cognition and general knowledge, and approach to learning (National Institute for Earl y Education Research, 2006). This study extends the literature on effective and comprehensive mental health programs for a preschool aged population by conducting a program evaluation on the effectiveness of a therapeutic playgroup model for providing mental health services to preschool aged children who exhibit social-emotional and behavioral problems due to family stress, abuse, neglect, and possible mental disorde rs of iv children and their caregivers. This study utilizes a mixed method design which incorporates data from caregivers, playgroup teachers, child records, and part icipantobservers. Findings indicate the effectiveness of the Therapeutic Playgroup Pr ogram in meeting the behavioral needs of preschool children, as well as overall program goa ls and objectives. Teacher efficacy was directly linked to effective and effic ient behavior and practices in providing mental health services to young children with challengi ng behaviors.
Hydration Status Assessment Techniques and Their Applicability Among Olympic Combat Sports Athletes: Literature Review

ABSTRACT IT IS GENERALLY ACCEPTED THAT VOLUNTARY WEIGHT CUTTING BEFORE ENTERING A COMPETITION HAS BECOME A HABITUAL PRACTICE AMONG COMBAT SPORTS ATHLETES. APART FROM ANTIDOPING REGULATIONS BANNING THE USE OF DIURETICS, THE OLYMPIC GOVERNING BODY HAS NOT ESTABLISHED POLICIES AIMED TO MONITOR AGGRESSIVE WEIGHT CUTTING. IT IS EXTREMELY IMPORTANT FOR COMBAT SPORTS ATHLETES TO REDUCE ADVERSE AND HEALTH-THREATENING SIDE EFFECTS EVOKED BY DIFFERENT APPROACHES TO ACHIEVING COMPETITION WEIGHT. THEREFORE, DEVELOPMENT AND IMPLEMENTATION OF RELIABLE AND ACCURATE HYDRATION ASSESSMENT TOOLS ARE WARRANTED. THE OBJECTIVE OF THIS ARTICLE IS TO REVIEW CURRENT RESEARCH FINDINGS OF MEASUREMENT CHARACTERISTICS CURRENTLY DEPLOYED IN COMBAT SPORTS RESEARCH.
Qualitätsmanagement und Leitlinien in der Intensivmedizin

D Although validated instruments are readily available for structured outcome assessment, this has been rarely employed in German intensive care units yet. Analysis of the effectiveness or efficiency of intensive care medicine without systematic assessment of outcomes and underlying structures and processes is impossible. Detailed knowledge of outcomes is mandatory, when continuous quality improvement is warranted. In the future, German intensive care units should implement regular outcome assessment to allow objective comparisons considering the particular case mix. Evidence-based guidelines may facilitate both, development of objectives, and assessment of outcomes. Owing to the advancement of medicine regular updates of guidelines are mandatory. Moreover, targets for the quality assessment need to be adjusted accordingly. This finally leads toward a continuous quality improvement process.
KNOWLEDGE, ATTITUDE, AND REPORTED PRACTICES OF A GROUP OF MINISTRY OF HEALTH DENTISTS TOWARDS PATIENTS WITH DIABETES MELLITUS IN ALEXANDRIA, EGYPT

INTRODUCTION: Diabetes and its acute complications have become a significant health hazard worldwide. To date, there are no data on the awareness of dental professionals regarding the management of diabetic patients. OBJECTIVES: The objective of this study was to assess the knowledge, attitude and reported practices of Ministry of Health dentists (MOH) regarding the oral complications associated with Diabetes Mellitus. MATERIALS AND METHODS: This study was a cross sectional descriptive survey of a sample of dentists working in the Egyptian Ministry of Health facilities, in Alexandria. The 349 participants were asked to complete a comprehensive, close-ended questionnaire, to assess the knowledge, attitude, and reported practices regarding diabetic patients. The first section was concerned with the demographic variables of the participating dentists. The second and third sections enquired about the participants’ knowledge and attitudes regarding diabetic symptoms, while the forth section of the questionnaire assessed the respondents’ reported practices concerning diabetic patients and actions taken toward the disease. RESULTS: Dentists participated in the study (n= 349 from 400 with a response rate of 87.25%) showed that Ministry of Health dentists had a good knowledge and favorable attitude toward diabetic patients visiting the Ministry of Health clinics, however, they had inadequate reported practices toward the same issue. CONCLUSIONS: THE present study showed relatively high level of awareness of dental practitioners regarding diabetes. Therefore, designing appropriate training programs for oral health care providers in order to enhance their practices towards the diagnosis and management of oral complications of Diabetes is mandatory
Diez años de experiencia de un centro de referencia en hipertensión arterial pulmonar en Uruguay

Introduccion: la hipertension arterial pulmonar (HAP) es una condicion clinica que conduce al fallo ventricular derecho y la muerte. Se caracterizo la epidemiologia de pacientes con HAP en un centro de referencia de Uruguay. Metodos: se incluyeron 52 pacientes adultos con diagnostico invasivo de HAP (enero 2006-diciembre 2016). Se estimo el riesgo mediante un modelo de cuatro variables (clase funcional [CF], distancia recorrida de 6 minutos [DR6M], presion auricular derecha e indice cardiaco). Se le asigno un valor de 1, 2 y 3 (bajo, intermedio y alto riesgo, respectivamente) a cada variable (Sociedad Europea de Cardiologia y European Respiratory Society 2015 [ESC/ERS 2015]). Se categorizo el riesgo mediante el redondeo al valor entero mas cercano del promedio de la suma de los valores asignados para cada variable. Resultados: edad 46±2 anos, 85% femenino. Predominaron la HAP idiopatica, HAP asociada a cardiopatia congenita (HAP-CPC) e HAP asociada a enfermedades del tejido conectivo (HAP-ETC). Los pacientes con HAP-CPC presentaron la mayor DR6M y la menor proporcion de CF III/IV (p < 0,05). La sobrevida fue menor en HAP-ETC (p = 0,069). La mortalidad al ano observada fue de 0%, 6% y 20% para pacientes con bajo (n=17), intermedio (RI, n=28) y alto (RA, n=7) riesgo, respectivamente, independientemente de la edad, sexo y subgrupo de HAP. El 51% de los pacientes con RI/RA recibieron tratamiento combinado. Conclusiones: se analizaron las caracteristicas y sobrevida de pacientes con HAP de un centro de referencia uruguayo. El modelo de riesgo permitio discriminar la mortalidad de los pacientes. El 51% de los pacientes con RI/RA recibieron tratamiento combinado.
Analysis of antiviral and chemprotective effects of strawberry anthocyanins

OF DISSERTATION ANALYSIS OF ANTIVIRAL AND CHEMPROTECTIVE EFFECTS OF STRAWBERRY ANTHOCYANINS This study investigated the antiviral, chemoprotective and proliferative effects of strawberry anthocyanins on herpes simplex virus type-1, cancerous cell lines HT-29 and AGS, and normal cell lines Hs 738.St/Int and CCD-18Co. Antiviral properties were measured by infecting vero cells from adult grivet (Cercopithecus aethiops) with herpes simplex virus type-1 (HSV-1) and treating with a concentration of 1.25-20 μg/mL of strawberry anthocyanins. Infectivity and replication were quantified for herpes simplex virus type-1 using the direct plaque assay and reporting PFU/mL. Strawberry anthocyanins (>20 μg/mL) inhibited the herpes simplex virus infectivity in vero cells by 100% (p<0.05). Strawberry anthocyanins at concentrations of 5, 10 and 20 μg/mL were reduced to 75.36, 57.98, and 31.46 percent of the control (100%) (p<0.05). Chemoprotective and proliferative effects of strawberry anthocyanins were analyzed for the human cell lines AGS, Hs 738.St/Int, HT-29, and CCD-18Co at a concentration of 25-200 μg/mL and quantified using the sulforhodamine-B assay. Growth inhibition occurred at a level of ≥87% for treatment concentrations 100 and 200 μg/mL for the cancerous AGS and HT-29 cell lines (p<0.0001). Proliferation rates for the normal Hs 738.St/Int and CCD-18Co cell lines increased at all treatment concentrations of 25-200 μg/mL (p<0.0001); suggesting that the observed proliferative activity may be associated with anthocyanin treatment. Strawberry anthocyanin treatment concentration worked in a dose dependent manner for the HSV-1 and the cancerous AGS and HT-29 cells. The caspase-3 assay was performed to demonstrate potential mechanism of action and confirmed that anthocyanin treatments play a role in apoptosis by the up regulation of caspase-3. Significant differences were seen between the growth characteristics of cancerous cell lines compared to their equivalent normal cell lines (p<0.0001). In summary, the antiviral findings suggest that strawberry anthocyanin extracts could be an effective topical treatment and/or prophylactic agent for oral herpetic infections (HSV-1). Also, the in vitro chemoprotective effect of strawberry anthocyanins found may be relevant to in vivo work in the future because when anthocyanins are consumed in the diet they come in direct contact with the gastrointestinal tract and may provide chemoprotection upon contact with the stomach and gastrointestinal tract’s epithelial cell layer.