Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Different Dietary Levels and Sources of Methionine on the Growth Performance of Turkeys, Carcass and Meat Quality

Abstract The aim of this study was to determine the effect of different dietary levels and sources of methionine (Met) on the growth performance of turkeys, carcass and meat quality. A total of 816 Hybrid Converter turkeys in 6 groups and 8 replications were fed wheat-soybean meal-based diets supplemented with three sources of Met: DL-isomer, L-isomer and DL-hydroxy analog (DLM, LM and MHA, respectively). In four 4-week periods (from 1 to 16 weeks of age), the Met content of turkey diets corresponded to the level recommended by NRC (1994) or was increased by approximately 50% to match the intake recommended by some breeding companies. Increased dietary Met content resulted in a higher final body weight (BW) of turkeys (P=0.002) and a lower feed conversion ratio (FCR) (P=0.049), but had no effect on carcass dressing percentage and most parameters of carcass quality. The higher dietary Met level contributed to a decrease in meat pH, a lower contribution of redness and a smaller muscle fiber diameter (P=0.028, P=0.040 and P=0.004, respectively). The higher dietary Met level had no influence on the redox status of meat, but it reduced the incidence of lymphoid cell infiltration between muscle fibers threefold (P=0.003). Throughout the experiment, no significant differences were noted in the growth performance parameters of turkeys, irrespective of Met source. MHA contributed to higher abdominal fat content, lower dry matter (DM) content and lower catalase (CAT) activity in breast meat, compared with DLM and LM. Increased dietary Met content, approximately 50% higher than that recommended by NRC (1994), regardless of Met source, led to higher final BW of turkeys, but had no effect on carcass dressing percentage and most parameters of carcass quality.
TITLE: Mesenchymal Stem Cells in the Bone Marrow Provide a Supportive Niche for Early Disseminated Breast Tumor-Initiating Cells

s/Posters: • Marsden C, Wright MJ, Carrier L, Krzysztof K, Pochampally R, Rowan B. 2011. “Primary Breast Cancer Cells With Metastatic Potential Isolated From Human Invasive Ductal Carcinoma” DOD Era of Hope Conference. • Marsden C, Wright MJ, Carrier L, Krzysztof K, Pochampally R, Rowan B. 2011. “Primary Breast Cancer Cells With Metastatic Potential Isolated From Human Invasive Ductal Carcinoma” Tulane Health Sciences Research Days. • Marsden C, Wright MJ, Carrier L, Pochampally R, Rowan B. 2010. “Isolation of Tumor Initiating Cells with Metastatic Potential from Human Primary Invasive Ductal Carcinoma” Tulane Health Sciences Research Days. • Marsden C, Wright MJ, Carrier L, Pochampally R, Rowan B. 2009. “Isolation of Tumor Initiating Cells with Metastatic Potential from Human Primary Invasive Ductal Carcinoma” CTRC-AACR Annual San Antonio Breast Cancer Symposium. • Marsden C, Wright MJ, Carrier L, Pochampally R, Rowan B. 2009. “Isolation of Tumor Initiating Cells with Metastatic Potential from Human Primary Invasive Ductal Carcinoma” e.Hormone. • Marsden C, Wright MJ, Carrier L, Pochampally R, Rowan B. 2009. “Isolation of Tumor Initiating Cells with Metastatic Potential from Human Primary Invasive Ductal Carcinoma” Louisiana Cancer Research Consortium Annual Retreat. • Marsden C, Wright MJ, Carrier L, Pochampally R, Rowan B. 2009. “Isolation of Tumor Initiating Cells with Metastatic Potential from Human Primary Invasive Ductal Carcinoma” Tulane Health Sciences Research Days. V. Conclusion Although breast cancer is diagnosed in about 10% of women between the ages of 40-50, Nielsen et al. detected subclinical lesions in 39% of women who died of trauma [30,31]. Microscopic lesions can remain asymptomatic for extended periods of time, with a high percentage never progressing to clinical manifestation [32,33]. Despite its important clinical implications in recurrence and metastatic latency, the mechanisms contributing to breast cancer dormancy remain poorly understood [34-36]. Current understanding of progression from dormancy to malignancy is significantly hindered by the lack of dormant tumor models that accurately recapitulate human breast cancer latency. Herein, we have developed a model that recapitulates human breast cancer metastasis, demonstrating a latency period with the potential for eventual malignancy. Primary breast tumor-initiating cells can be isolated as tumorspheres
Longest Survival with Renal AA Amyloidosis: Development of End Stage Renal Disease after 25 Years of AA Amyloidosis Diagnosis

This is case report of a patient who was diagnosed with secondary AA Amyloidosis of the kidneys due to Pulmonary Tuberculosis in 1973. AA Amyloidosis was diagnosed based on renal biopsy due to heavy proteinuria. Nephrotic Syndrome and concomitant renal insufficiency resolved after treatment of tuberculosis. Patient remained proteinuria free with preservation of renal function for more than 25 years. He presented to the same hospital 25 years later with heavy proteinuria and advanced renal failure. The work up of renal failure was inconclusive during this admission. He underwent a repeat diagnostic renal biopsy which revealed AA Amyloidosis present throughout the kidney. Rectal and minor Salivary gland biopsies also revealed AA amyloidosis. The patient was started on chronic renal replacement therapy but unfortunately expired after few months due to bacteremia.
Benford Behavior of Zeckendorf Decompositions

A beautiful theorem of Zeckendorf states that every integer can be written uniquely as the sum of non-consecutive Fibonacci numbers $\{ F_i \}_{i = 1}^{\infty}$. A set $S \subset \mathbb{Z}$ is said to satisfy Benford's law if the density of the elements in $S$ with leading digit $d$ is $\log_{10}{(1+\frac{1}{d})}$; in other words, smaller leading digits are more likely to occur. We prove that, as $n\to\infty$, for a randomly selected integer $m$ in $[0, F_{n+1})$ the distribution of the leading digits of the Fibonacci summands in its Zeckendorf decomposition converge to Benford's law almost surely. Our results hold more generally, and instead of looking at the distribution of leading digits one obtains similar theorems concerning how often values in sets with density are attained.
Shape-based coordination in locomotion control

Highly articulated systems are capable of executing a variety of behaviors by coordinating their many internal degrees of freedom to help them move more effectively in complex terrains. However, this inherent variety poses significant challenges that have been the subject of a great deal of previous work: What are the most effective or most efficient methods for achieving the intrinsic coordination necessary to produce desired global objectives? This work takes these questions one step further, asking how different levels of coordination, which we quantify in terms of kinematic coupling, affect articulated locomotion in environments with different degrees of underlying structure. We introduce shape functions as the analytical basis for specifying kinematic coupling relationships that constrain the relative motion among the internal degrees of freedom for a given system during its nominal locomotion. Furthermore, we show how shape functions are used to derive shape-based controllers (SBCs) that manage the compliant interaction between articulated bodies and the environment while explicitly preserving the inter-joint coupling defined by shape functions. Initial experimental evidence provides a comparison of the benefits of different levels of coordination for two separate platforms in environments with different degrees of inherent structure. The experimental results show that decentralized implementations, where there is relatively little inter-joint coupling, perform well across a spectrum of different terrains but that there are potential benefits to higher degrees of coupling in structured terrains. We discuss how this observation has implications related to future planning and control approaches that actively “tune” their underlying structure by dynamically varying the assumed level of coupling as a function of task specification and local environmental conditions.
A pneumococcusvakcináció gyakorlata a családorvosi praxisokban

Bevezetés: Az invazív pneumococcusbetegség előfordulása 50 éves kortól emelkedik. Vakcináció ajánlott, az átoltottság mégis igen alacsony. Célkitűzés: A szerzők az inﬂ uenza ellen oltottak tájékoztatásának, a tájékoztatást nyújtó kilé-tének hatását vizsgálták az oltás felvételére. Módszer : Húsz praxisban, a 2012/2013-as inﬂ uenzaoltási kampányban megjelenő 50 év feletti személyek kérdőívet töltöttek ki és tájékoztatást kaptak a pneumoccusvakcináció fontosságá-ról. Eredmények: 4000 személy közül 576 kért receptet, a nők 16,5%-a, a férﬁ ak 11,6%-a (OR 1,67; CI 95% 1,37– 2,04; p<0,001), átlagéletkoruk 70,95 év, illetve 69,8 év volt (OR 1,01; CI 95% 1,00–1,02; p<0,05). Családorvosi tájékoztatás The mean age of females and males was 70.95 and 69.8 years, respectively (OR 1.01; CI 95% 1.00–1.02; p<0.05). Information given by physicians resulted in 33,6% prescription rate, while in case it was 8% when nurses provided information (OR 6.33; CI 95% 5.23–7.67; p<0.001). As an effect of this study the vaccination rate was 6.3 times higher than in the previous year campaign (p<0.001). Conclusions: General practition-ers are more effective in informing subjects about the importance of vaccination than nurses. Campaign can raise the vaccination rate signiﬁ cantly.
Magnesium and Drug Interactions: Review

Unfortunately, hypomagnesaemia is the most underdiagnosed electrolyte deficiency in current medical practice, means of diagnosing clinical magnesium deficiency of a lesser degree than other electrolyte deficiency associated with overt signs, such as convulsions or cardiac arrhythmias or other electrocardiographic changes are not readily accessible. Plasma magnesium levels are unreliable as an index of its cellular inadequacy, because the means of evaluating magnesium status are complicated. Until magnesium clinical methodology is improved and made available, the importance of correcting magnesium deficiency in man's diet and of preventing intensification of a deficit when needs are increased by physiologic or pathologic processes and drugs, it will have to be inferential- based on suggestion of experimental and epidemiologic observations. Because magnesium has pharmacologic activities that has been recognized for many years, demonstration of the correction of abnormal acute neuralogic and cardiac signs (even though such signs are characteristic of acute magnesium deficiency) are not readily accepted as evidence that magnesium deficiency can contribute to diseases in which such magnesium-responsive signs are seen. With notable exceptions, there has been clinical neglect of magnesium in most medical centers all over the world. This is unfortunate because many of the pathogenic changes produced by experimental magnesium deficiency or loss resemble many of those of chronic diseases that are responsible for intractable medical problems. This review is to emphasize that magnesium is essential in health and disease status, and to call the medical and scientific organization for the objective examination of the evidence, and for the exploration of the possibility that the prophylactic and treatment uses of magnesium might be effective, and this review also shows the mechanisms of interactions between some drugs and magnesium.
Identifying Molecular Factors in Androgen Receptor Nuclear Export

Abstract : Androgen receptor (AR) plays a central role in prostate cancer and the regulation of its nuclearicytoplasmic transport represents another level control of its activity. However how AR is transported into and out of the nucleus remains largely a mystery. Yeast (S. cerevisiae) provides a powerful system to study fundamental cellular mechanisms. Thus we use yeast as a model system to identify factors that are involved in the AR nuclear export. A mutagenesis screen was performed and thus far 6000 individual clones (about I yeast genome) have been examined. Seven mutants that displayed a defect in nuclear export were isolated. Preliminary results suggest that one mutant yeast clone 27.7D is a recessive gene that may play a role in the nuclear localization of AR. In addition the mutant clone 27.7D also exhibit retarded growth. The export and growth defects observed in clone 27.7D appear to be caused by the same mutation or two separnte but very closely linked mutations. Complementation experiments show that 27.7D is distinct from two other mutants clones I . 3E and 72.5E which are actively being characterized. Initial results also suggest that the combination of the mutation in 27.7D and the mutation of another mutant clone I 02.5D results in lethality. This suggests the possibility that these two genes may belong to two parallel pathways.
DB-ALM Protocol n ° 113 : Embryonic Stem Cell Test ( EST )

Disturbances of ES cell differentiation following treatment of xenobiotics indicate a potential of embryotoxicity for early pre-implantation stages of mammalian development. The Embryonic Stem cells Test (EST) has been proposed as a screening assay for potentially embryotoxic substances and for their classification into three different classes of in vivo embryotoxicity (strong, weak and not embryotoxic) (Genschow et al., 2002; Spielmann et al., 1997).
NATURAL DURABILITY AND PERFORMANCE OF HORNBEAM CEMENT BONDED PARTICLEBOARD

Cement bonded particleboards were manufactured from hornbeam (Carpinus betulus L.) wood particles. Hydration tests were carried out to determine the inhibitory index in order to characterise wood-cement compatibility. The results revealed that the mixture of hornbeam -cement can be classified as moderate inhibition. Two wood: cement ratios were applied in this study, namely 1:3 and 1:4, for the board manufacture. It was found that an increase of cement-wood ratio resulted to an increase in all, but MOR values. All properties of the boards made from 1:4 wood: cement ratio, surpassed the minimum requirements set forth by the building type HZ code. Boards were exposed to brown and white rot fungi, Coniophora puteana, Trametes versicolor respectively. Overall, both fungi failed to attack the cement-bonded boards.
Assessment of the dynamic growth of the fattening pigs from body weight measured daily and automatically to elaborate precision feeding strategies

Growing pigs are often fed below ad libitum to increase their feed efficiency and carcass leanness. When energy supply is under control, precision feeding is implemented through the amino acids (AA). As the AA requirement depends on the body weight (BW) for the maintenance part and on its daily variation (ΔBW) for the growth part, the adequacy between requirements and supplies on day D+1 depends on the adequacy of predicted BWD+1 and ΔBWD+1. Data sets from four trials were used to forecast BW from time series analyses based either on multivariate adaptive regression splines (MARS) or double exponential smoothing (HWα) methods using the k latest data (8, 14 or 20). Pigs (n = 117) were group-housed and restrictively fed, and their BW was recorded daily and individually with an automatic scale (n = 11 736). With HW0.6, the RMSEP of BWD+1 was the smallest one (1.21 kg) and not influenced by k. Linear regression on the l latest forecasted BW was used to assess ΔBWD+1. At the beginning of the trial, ΔBWD+1 was more difficult to predict from BW forecasted with MARS than with HW0.6. Descriptive statistics of individual variation of ΔBWD+1 based on MARS and HW0.6 were comparable with k = l = 20 only after removal of the first 19 days. Compared to other methods studied, the method HW0.6 seems to be the best compromise to forecast BWD+1 and ΔBWD+1 of restrictively fed pigs.
Brief DeNnitive Report

Recently it was found that broad spectrum anti-Ia k (A.TH anti-A.TL) antiserum could block the activation of Iak-restricted F1 T helper cells in vivo (1). Thus, (CBA × B6)F1 (H-2 k X H-2 b) T cells exposed to sheep erythrocytes (SRC) for 5 d in irradiated F1 mice in the presence of anti-Ia k antibody provided high levels of help for B10 (LA b, I-B b, I-J b, I-E b, I -U) (bbbbb) or Fx B cells, but not for B10.BR (kkkkk) or B10.A(4R) (kbbbb) B cells. Surprisingly, monoclonal anti-I-A k antibody failed to inhibit the generation of help for B10.BR or B10 B cells, but effectively blocked help for B10.A (4R) B cells. This finding implied that Iak-restricted T cells fall into two subgroups, one set of cells being restricted by I-A k determinants, and the other restricted by determinants mapping to the right of the I-A subregion. In view of the known biochemistry of Ia molecules (2-4), it was argued that this second T cell subgroup was probably restricted by determinants on I -A/E molecules. The latter molecules each consist of an/ -E-encoded a chain (E~) associated with an/-A-encoded j3 chain (E¢, also termed A~); structurally (2-4) and functionally (5), I -A/E (E~-E,) molecules resemble the set of I-A (A¢-A,) molecules, the a and ,8 chains of which are both encoded in the I-A subregion. The notion that Iak-restricted T cells comprise a mixture of I-A kand I-Ak/E krestricted cells implies that the blocking effects of A.TH anti-A.TL antiserum (which is known to include activity for both I-A k and I-Ak/E k determinants) could be mimicked by a mixture of monoclonal anti-I-A k and anti-I-Ak/E k antibodies. This paper investigates the blocking effects of several monoclonal antibodies, including the hybridoma Y-17, which detects a public specificity on the I-Ak/E k molecule (5). We show here that although Y-17 alone has no demonstrable effect on T helper cell induction, a mixture of Y-17 plus anti-I-A k antibody (hybridoma 10-3.6) virtually abolishes the activation o f help for Ia k (B10.BR) B cells.
Content-based Classification of Fraudulent Webshops

In this research, we evaluate the possibility of classifying fraudulent webshops on the basis of website content. Fraudulent webshops form a problem on the Internet and the Dutch Consumers Association (Consumentenbond) reports that at least one out of five webshops in the . nl top level domain (TLD) acts in a fraudulent manner. Content-based classification can be part of the detection and mitigation strategy. This method demonstrates the viability of this approach, and follows multiple steps. First, we identified prerequisites necessary for running a successful fraudulent webshop. Second, based on these prerequisites, features were engineered to classify these fraudulent webshops. Third, a classification model was trained, resulting in an F1-score of 99.15% using 10-fold cross validation. Fourth, this trained model classified an unlabelled dataset of 4.9M domains. Although results include many false positives, we estimate the precision to be 30.1%. This would imply that out of 32,815 positively classified domains, 9,877 are correctly identified fraudulent webshops. Furthermore, we also estimate that results in general will improve if more optimisations are conducted. Ultimately, our contribution is constituted on the demonstration that a content-based classification method is viable and the presentation and analysis of characteristics and features used. The software resulting from these experiments online.
Multiband LTE-A/WWAN Antenna for a Tablet

In this paper, an internal multiband antenna is proposed for LTE-A/WWAN wireless applications in tablet computer. The proposed antenna is configured to have two branch radiators. These two branch radiators are a U-shaped driven monopole and a nonuniform wrapped inverted U-shaped monopole. The impedance bandwidths across dual operating bands are 89.7 MHz and 4185 MHz at the LTE-A/WWAN bands. Various techniques, such as branching and parasitic element are used to enhance the antenna’s bandwidth, the matching, and the size of the proposed antenna. The antenna is presented on an area of 50 × 15 mm2. Experimental results of this antenna show nearly omni-directional coverage and stable gain variation across the LTE-A/WWAN bands.
Security Analysis of Monero’s Peer-to-Peer System

Every cryptocurrency has an underlying peer-to-peer networking system that provides other pieces of the software with as fair and complete of a view of the network as possible. Nodes in the network need to receive all relevant messages (transactions and new blocks) in a timely manner in order to prevent potential attacks from malicious nodes. Prior work [2, 3] has demonstrated one such attack called an eclipse attack on Bitcoin and Ethereum. They were able to take over all incoming and outgoing connections of victim nodes with relatively little computation resources. Cryptocurrencies must defend against this by taking precautions in how they form their peer-to-peer networks. In this work, we explore the potential for eclipse attacks on the cryptocurrency Monero. Monero is a opensource [1] cryptocurrency that places a greater emphasis on anonymity than most other cryptocurrencies. Implementing the Cryptonote protocol, it uses ring signatures and stealth addresses to obfuscate the sender, recipient, and amount of every transaction by default. Like all cryptocurrencies, it relies on a P2P network to distribute information about its blockchain. We chose Monero specifically because its design has many similarities to Bitcoin, but unlike several other cryptocurrencies, it is not a direct copy of Bitcoin. In this paper, we first present prior work on eclipse attacks and their countermeasures for Bitcoin and Ethereum. Then, we describe Monero’s P2P network in detail. Lastly, we highlight the strengths of Monero’s system design and propose potential weak spots and countermeasures. Our work was done by analyzing the Monero source code found on Github with the commit hash 4b728d7dd48584987f53995a141baac4f886f017.
Mastitis in Goats – Diagnosis and Management

The present study was carried out in 32 goats over a period of 10 months that were presented with the history and signs related to abnormalities of udder, milk composition and other general signs and milk samples were collected from each affected udder lobe in a sterile container and subjected to cultural and antibiogram studies. Samples were reveled that Staphylococcus, E. coli, and Pseudomonas were the common bacterial organisms responsible for Caprine Clinical Mastitis and AmoxycillinClavulanic Acid was highly effective antibiotic in treating such cases.
Effect of Menstrual Cycle Phase on Muscle Fatigue and Physical Performance During High Altitude Acclimatization.

Abstract : To characterize skeletal muscle function in women during altitude exposure, 19 women (22 +/- 1 yr; mean +/- SE) with normal menstrual cycles were studied at sea level (SL, days 1, 5, and 9 of the follicular and luteal phases) and after 1, 5 and 9 days of continued exposure to 4300 m (days 2, 6 and 9-10 of the follicular or luteal phase). Maximal voluntary contraction force was measured before ('strength') and every min during intermittent static contraction exercise (50% of strength, 5 sec contraction/5 sec rest) of the adductor pollicis muscle and every 2 mins during dynamic contraction exercise (18 +/- 2% of strength at a contraction rate of 1 Hz) of the quadriceps femoris muscle, to exhaustion. Major findings were: (1) strength and time to exhaustion did not vary significantly (P > 0.05) between menstrual phases or among days within each phase at SL or altitude, and (2) endurance time to exhaustion for women --- in sharp contrast to male historical controls --- was similar at altitude as at SL. (Men have a much greater reduction in endurance time). The gender difference in muscle endurance was independent of menstrual phase and remained despite men and women having identical levels of strength and exercising to exhaustion at a similar work rate.