Miracle-dz/UniFAR-FTUs huggingface dataset:
A Case of Lyme Disease Presenting with Erychema (Chronicum) Migrans

Lyme disease (Lyme borreliosis) is a vector-borne infection primarily transmitted by Ixodes species and caused by a spirochete, Borrelia burgdorferi. This disease affects multiple areas such as skin, joints, eyes, nervous and cardiovascular systems. Erythema (chronicum) migrans, borrelial lymphocytoma and acrodermatits chronica atrophicans are the cutaneous hallmarks of Lyme disease. A 31-year-old man presented with an annular centrifugally expanding erythematous plaque with central punctum on the left scapular area for about 2 months. He was bitten by a tick 3 months ago in Kangwondo. Serologic examinations revealed increased levels of Ig M and Ig G antibodies to borrelial antigen in consecutive tests performed at an interval of three weeks. Western blot for Borrelia burgdorferi was also positive. The skin lesion showed prompt response to the tetracycline therapy and was cured after 2 weeks.
Design of 8-Point DCT Architecture with 12 Addition Only for Image Compression

-The DCT is engaged in multitude of compression standards due to the remarkable energy compaction properties. Approximate DCT transform have been proposed that offer superior compression performance at very low circuit complexity based on addition and subtraction without any multiplication and shifting operations. In this paper, 8-point approximate DCT is introduced with 12 addition only for image compression. Besides A1CSA is introduced for addition and subtraction operations and transpose memory is also introduced for computing approximate 2D-DCT. A1CSA and transpose memory further reduce the computational complexity, power consumption, chip area and critical time delay and achieves a performance in image compression that is comparable to that of the existing approximated DCT. The proposed approximate DCT is implemented on Xilinx Spartan 3E field programmable gate array (FPGA) device and synthesized with standard cell library.
Celeribacter ethanolicus sp. nov., isolated from seawater of the South China Sea

Objective A novel Celeribacter strain NH195T was isolated from seawater of the South China Sea and was subjected to polyphasic taxonomic study. Methods Phenotypic, genotypic and chemotaxonomic characterizations, as well as phylogenetic inference were performed in this study. Results Strain NH195T was a Gram-stain-negative, aerobic, rod-shaped, non-motile bacterium that accumulates poly-β-hydroxybutyrate (PHB). The isolate grew in media containing 0.5%−10.0% (W/V) NaCl (optimally at 1.0%−3.0%) at 20−40 °C and pH 5.0−9.0, and was positive for oxidase, catalase and urease. The respiratory quinone was Q-10. The major fatty acids (>10%) were C18:1ω7c, C18:1ω6c and 11 methyl C18:1ω7c. The major polar lipids were phosphatidylcholine (PC), phosphatidylglycerol (PG), diphosphatidylglycerol (DPG), one unidentified aminolipid and two unidentified lipids. The genomic DNA G+C content was 61.3 mol%. Phylogenetic analysis based on the 16S rRNA gene sequences indicated that strain NH195T could be assigned to the genus Celeribacter. The 16S rRNA gene sequence similarities between the isolate and the type strains of Celeribacter species with validly published names were in the range 94.4%−97.7%. Strain NH195T exhibited average nucleotide identity (ANI) values of 78.6% and 78.0% to C. halophilus ZXM137T and C. indicus P73T respectively. The genome-to-genome distance analysis revealed that strain NH195T shared 26.1% DNA relatedness with C. halophilus ZXM137T and 23.0% with C. indicus P73T, respectively. Conclusion On the basis of phenotypic and genotypic characteristics, strain NH195T represents a novel species within the genus Celeribacter, for which the name Celeribacter ethanolicus is proposed. The type strain is NH195T (=CGMCC 1.15406T=JCM 31095T).
Lattice-based Key-sharing Schemes

Public-key cryptography is an indispensable component used in almost all of our present-day digital infrastructure. However, most if not all of it is predominantly built upon hardness guarantees of number theoretic problems that can be broken by large-scale quantum computers in the future. Sensing the imminent threat from continued advances in quantum computing, NIST has recently initiated a global-level standardization process for quantum resistant public-key cryptographic primitives such as public-key encryption, digital signatures, and key encapsulation mechanisms. While the process received proposals from various categories of post-quantum cryptography, lattice-based cryptography features most prominently among all the submissions. Lattice-based cryptography offers a very attractive alternative to traditional public-key cryptography mainly due to the variety of lattice-based schemes offering varying flavors of security and efficiency guarantees. In this article, we survey the evolution of lattice-based key-sharing schemes (public-key encryption and key encapsulation schemes) and cover various aspects ranging from theoretical security guarantees, general algorithmic frameworks, practical implementation aspects, and physical attack security, with special focus on lattice-based key-sharing schemes competing in the NIST’s standardization process.
Geographical restructuring of Arabidopsis thaliana’s genetic makeup in the Iberian Peninsula due to climate change based on genetic cluster membership

Aim To assess the effects of climate change on genetic lineages of Arabidopsis thaliana at the admixed population level by directly modelling genetic cluster membership values to predict potential genetic cluster memberships across the Iberian Peninsula. Location Iberian Peninsula Methods We used a dataset of 274 accessions structured in four genetic clusters as inferred from 250 nuclear single-nucleotide polymorphisms with Bayesian clustering methods. We predicted the change in percentages of genetic cluster membership at a population level and the changes in potential suitability across the study area by combining parametric (Beta regression) and non-parametric (Recursive trees) methods. Results Climate change will affect genetic lineages of Arabidopsis thaliana differently. Genetic clusters GC1 and GC2 will suffer a substantive reduction of their respective suitable areas while GC3 and GC4 will expand northward. At the population level, except for GC4, the rest of the lineages will undergo a genetic turnover for many of their populations. Main conclusions A. thaliana in the Iberian Peninsula will undergo a major internal genetic restructuring and range change due to climate change. Genetic lineages of Arabidopsis thaliana in the Iberian Peninsula will be affected differently which reinforce the need for taking into account intraspecific genetic variation when modelling species distribution. Despite limited predictive power of individual statistical models, the combination of distinct models can compensate this shortcoming.
Digestion of Oligonucleosomes with Micrococcal Nuclease

INI1 is an important protein in the Switch/Sucrose Non-Fermentable (SWI/SNF) complex. It is related to Malignant Rhabdoid tumors (MRT) that appears in infants. Its function is still a mystery, but in children that have MRTs, INI1 is missing or truncated. In this experiment, we digested chromatin from natural cells with Micrococcal nuclease (MNase) so that in future experiments we can run an EMSA to determine if INI1 binds to mono-nucleosomes. Two separate experiments were run with samples containing long oligonucleosome (LON) and different concentrations of MNase. After running titrations of differing concentrations of MNase, it is my conclusion that the proper concentration of MNase to digest chromatin to a single nucleosome is 1×10 -5 units/microliter (units/µL). This concentration produced more mono-nucleosomes and less product of other species.
OF A FIELD VOLE METAPOPULATION

Although metapopulation theory is widely used in basic and applied ecology, there are still few empirical studies that explore the relationships between dispersal, patch size, and the persistence of natural populations. Here, we reanalyzed data from a six-year study of a spatially structured field vole (Microtus agrestis) metapopulation in the Tvir- minne archipelago, Finland. Our goal was to address several issues relevant to metapo- pulation studies: (1) the relationships between within-subpopulation dynamics, dispersal behavior, habitat quality, and metapopulation dynamics; (2) the generality of one of the most common conclusions of metapopulation theory-that smaller and less frequently in- habited islands are less important for metapopulation dynamics; and (3) the comparison of different methods for understanding and predicting dynamics in "metapopulation-like" systems. Our results suggest that this vole metapopulation is driven by extinctions and colonizations of island subpopulations. However, contrary to expectation, colonizations by voles from tiny, ephemeral skerry subpopulations were about as important for metapopu- lation persistence as were colonizations from the more persistent subpopulations on large islands. This pattern resulted from less stable vole densities on smaller islands, combined with increased emigration preceding subpopulation extinctions. Either spatially implicit Levins models or incidence function models provided reasonable predictions of the structure and function of this metapopulation, but parameters fitted to incidence functions varied dramatically among years. Our results suggest that models of real metapopulations need not become highly detail oriented or spatially complicated to provide good predictive power. However, applications of metapopulation theory require careful consideration of how un- derlying ecological and behavioral mechanisms will shape metapopulation dynamics of particular species and situations.
Association of polymorphic G1934A variant (allele *4) of CYP2D6 gene with increased risk of breast cancer development in Ukrainian women.

BACKGROUND: Breast cancer (BC) is among the most common oncologic pathology in economically developed countries where it afflicts nearly 10% of women. Polymorphism of CYP 2D6 gene is shown to be associated with increased risk of development of a number of pathologies, in particular cancer. AIM: The work was directed on evaluation of the role of polymorphism G1934A (allele *4) of CYP 2D6 gene in elevated risk of BC development in Ukrainian women. MATERIALS AND METHODS: In the study there were enrolled 85 patients (group І) with histologically verified BC diagnosis of stages I and ІІ. Clinical-genealogic study has been performed by the method of patient survey and following analysis of genealogy. Earlier obtained data on the frequency of genotypes and alleles of CYP 2D6 gene in 637 Ukrainian people have been used as a control. For determination of allele variant *4 (G1934A) of CYP 2D6 gene the method of PCR-RFLP has been used. RESULTS: An increased risk of BC development in hereditary tainted patients with genotype *4*4 of CYP 2D6 gene compared to the control group has been revealed. The frequency of *1*4 (IM) genotype has been found to be increased in the group of women with a family history of cancer (41.79%). Significant difference between the frequency of *1*1 (ЕМ) and *1*4 (ІМ) genotypes in females with PR-positive and PR-negative tumors in the group of hereditary tainted patients has been registered. CONCLUSION: In conclusion, our study has revealed an increased risk of BC development in hereditary tainted patients compared to control group with genotype *4*4 (РМ).
Tractography-based connectomes are dominated by false-positive connections

Fiber tractography based on non-invasive diffusion imaging is at the heart of connectivity studies of the human brain. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain dataset with ground truth white matter tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. While most state-of-the-art algorithms reconstructed 90% of ground truth bundles to at least some extent, on average they produced four times more invalid than valid bundles. About half of the invalid bundles occurred systematically in the majority of submissions. Our results demonstrate fundamental ambiguities inherent to tract reconstruction methods based on diffusion orientation information, with critical consequences for the approach of diffusion tractography in particular and human connectivity studies in general.
Accountability for the Economy at All Levels of Government in United States Elections∗

A large literature on economic voting in the United States finds that the president’s party is rewarded in presidential elections for strong economic performance and punished for weak performance. In contrast, there is no clear consensus about whether the local economy matters in elections at other levels of governments. In this study, we compile the largest dataset to-date on the link between the local economy and elections in the United States. We use administrative data on county-level economic conditions from 1969-2016 to examine the effect of the local economy on elections for city, county, state, and national government. We find clear evidence that the president’s party is held accountable for economic performance across nearly all levels of government. In contrast, there is much weaker evidence that the party that controls other levels of government is held accountable for the economy. We also examine whether the media moderates accountability, and find tentative evidence that counties that receive more media coverage are more likely to hold the president’s party accountable in federal (but not state and local) elections. Overall, our findings show that politicians from the president’s party have strong electoral incentives to grow the local economy, while politicians in the opposition party have clear incentives to stymie economic growth. ∗We are grateful to participants in the UCLA Political Science workshop for feedback on a previous version of this manuscript. †Postdoctoral Research Associate, Boston Area Research Initiative, Harvard University and Northeastern University, jdbk@iq.harvard. edu ‡Assistant Professor, Department of Political Science, George Washington University, warshaw@gwu.edu
Morphology of the Testis and Epididymis of Large White Boars

The testis and epididymis of twenty five adult Large White boars were used to investigate the biometric and histomorphometric parameters of the testis and epididymis of the boars. The aim of the study was to provide information which could be useful in the comparative regional anatomy of the male reproductive organs of domestic animals and thus an improved assessment of breeding soundness and fertility potential in boars. The average weight of the animals was 71.3 ± 10.7 kg. The average weights of the right and left testes were 170 ± 0.7. 60 g and 179±6.48g, respectively with no significant dif¬ference. The average weights of the right and left epididymis were 40.9 ± 6.81 g and 43.7 ± 8.55 g, respectively, with no significant difference. The relative testicular and epididymal weights were 0.49% and 0.12%, respectively. This study shows that the testis is about four times the size of the epididymis. The ductal diameter of the head, body and tail of the epididymis were 418 ± 22.6 µm, 432 ± 20.3 µm and 939 ± 50.6 µm, respectively. The mean relative volume of the germinal epithelium, interstitium and lumen of the seminiferous tubules of the boars rats were 68.4 ± 3.46%, 5.5 ± 0.66% and 78.0 ± 4.81%, respectively. It can be concluded that the morphology of the testis and epididymis of the Large White boar are similar to those of most mammals. This work provides information the testis and epididymis of the Large White boar which could be useful in the comparative regional anatomy of the male reproductive organs of domestic animals and thus an improved assessment of breeding soundness and fertility potential in boars.
Estimation of distribution of a commensal thermophile in soil by competitive quantitative PCR and terminal restriction fragment length polymorphism analysis

Symbiobacterium toebii has been previously reported as a novel commensal thermophile exhibiting a commensal interaction with thermophilic Geobacillus sp. SK-1. We investigated the distribution of this commensal thermophile in various soils using molecular methods, such as quantitative PCR and terminal restriction fragment polymorphism analysis. Based on a nested competitive quantitative PCR, the 16S rDNA of the commensal thermophile was only detected in compost soils at about 1.0×10 4 copies per gram of soil, corresponding to 0.25×10 4 cells per gram of soil. However, in an enrichment experiment at 60°C, about 1.0×10 8 copies of 16S rDNA molecules were detected per ml of enriched culture broth for all the soils, and more than 0.1 mM indole accumulated as the product of commensal bacterial growth. When incubated at 30°C, neither the 16S rDNA of the commensal bacterium nor any indole accumulation was detected. Accordingly, even though the 16S rDNA of the bacterium was only detected in the compost soils by a nested PCR, the presence of the 16S rDNA molecules of commensal thermophile and accumulation of indole in all the enriched cultures appeared to indicate that the commensal thermophile is widely distributed in various soils.
Conservation (In)Action: Renewing the Relevance of UNESCO Biosphere Reserves

The research and policy landscape for biodiversity conservation is changing. Protected areas are now expected to meet a broad range of objectives including effective and equitable management. In this new landscape, organizations strive to find ways to ensure the rights of local and Indigenous peoples are respected while conservation scientists have endorsed the need for platforms for international research and practice. For 40 years, a growing international network of sites support such research and practice, yet, it has been underutilized and largely ignored by scientists and decision‐makers alike. To better understand this paradox, this article explores the evolution of the World Network of UNESCO Biosphere Reserves internationally and its application in Canada. Analysis of archived materials, a national survey of practitioners, and interviews with past and present members of Canada's national committee reveals an expanded mandate for biosphere reserves beyond conservation science and biodiversity protection. The article recommends that to support the expanded conservation agenda, biosphere reserves work with governments and conservation scientists to connect more effectively with global concerns and initiatives such as the Convention on Biological Diversity and Sustainable Development Goals; establish appropriate, reliable, and active transdisciplinary partnerships; and meaningfully engage a broader range of knowledge holders.
DIVA strategies in avian influenza virus; present scenario

For the successful eradication campaign of AIV two parameters are to be considered, which are the successful and complete vaccination complemented with the highly specific monitoring programme that can differentiate well between infected and vaccinated animals (DIVA). In all 6 DIVA strategies are applied for monitoring which are (1) Sentinel birds (2) Hetrologus NA strategy (3) Use of subunit vaccine (4) NS1 serology (5) M2e (Transmembrane protein) (6) HA2 glycoprotein based.
EFFECT OF L-CARNITINE ADMINISTRATION ON GROWTH PERFORMANCE, RUMEN AND BLOOD PARAMETERS AND CARCASS TRAITS OF GROWING Rahmani LAMBS

The current study was carried out at Animal Experimental Station and the Laboratory of Physiology and Biotechnology, belonging to the Animal Production Department, Faculty of Agriculture, Mansoura University, during the period from September to December 2014. The aim of this experiment is to study the effect of daily oral administration of free L-canitine (LC) at two levels (350 and 700 mg/h/d) during an experimental period of 63 days on growth performance, rumen and blood parameters, and carcass quality of growing Rahmani lambs. A total of nine Rahmani lambs weighing 33.9±0.69 kg and about 10 months old were assigned according to body weight into 3 groups which were then assigned at random to receive the three experimental treatments. Animals in the 1 st group (G1) were fed the control diet (14.4% CP). The 2 nd and 3 rd groups were fed the same diet, but orally treated with LC at levels of 350 (G2) and 700 (G3) mg/h/d for 63 days as an experimental period. Growth performance parameters, rumen and blood parameters at slaughter and carcass traits were determined. The obtained results revealed that overall feed intake by lambs in G2 and G3 was reduced by about 2.4 and 6.1% as compared to the controls during the whole feeding period. Live body weight of lambs in G2 and G3 was slightly lighter than that in the control group during all intervals of the experimental period. Averages of total and daily body gains of lambs were not significantly affected by LC treatment, although total gain was slightly higher in G2 and slightly lower in G3 than in G1. Feed conversion was almost the best in G2 than in G3 and G1 during feeding intervals or during the experimental period. Ruminal pH value and NH3-N concentration decreased (P<0.05) in G2 as compared to that in G1, being 6.88 and 8.88 mg/dl, and 7.2 and 17.77 mg/dl, respectively. However, pH value and NH3-N concentration insignificantly decreased to 7.06 and 13.62 mg/dl in G3, but did not differ significantly from those in G2 and G1. Total VFA’s concentration in rumen liquor increased (P<0.05) by about 34.7% in G3 as compared to G1. While, nearly similar VFA’s concentration was obtained for G2 and G1 (16.33 mEqui./dl). Only concentration of total proteins in blood plasma decreased (P<0.05) in G2, while triglycerides concentration decreased (P<0.05) in G2 and G3 by about 52.6 and 50.3% as compared to G1, respectively. Concentration of thyroid hormone (T3) insignificantly increased in G2 and G3 (1.95 and 1.68 ng/ml) as compared to 1.6 ng/ml in G1, respectively. The LC had no effect on urea-N concentration in blood plasma. Carcass traits were not significantly affected by LC treatment, although there was an increase in dressing percentage of lambs in both treatment groups (G2 and G3, being 48.13 and 50.94% as compared to 47.93% in the control lambs, respectively. It could be concluded that LC treatment slightly improved feed conversion as a result of improving rumen
On the road again - the antibiotic resistance superhighway

Antibiotic resistance (AMR) in Gram-negative bacteria, has expanded massively in recent years and is now of global public health concern. AMR determinants in many cases have originated from environmental bacteria. Horizontal gene transfer (HGT) has facilitated the dissemination of these genes to organisms of different species and genera, including those of clinical relevance. HGT occurs by three broad mechanisms, namely conjugation, transformation and transduction. Key elements of HGT include insertion sequences, transposons, integrons and other mobile genetic elements (MGEs) such as plasmids.