Miracle-dz/UniFAR-FTUs huggingface dataset:
E-supporting Performance Styles based on Learning Analytics for Development of Teaching Practices in Teaching Science

This study aims to identify the effectiveness of delivering electronic supporting performance styles that are based on learning analytics for the development of teaching practices in teaching science, moreover, the Electronic and face to face supporting performance styles will deliver according to the data analytics that extracted from observations, (participating rate-page views) data from platform, therefore, to determine the effectiveness, the researchers design observation rubric based on teaching practices standard that extract from (ASTE/NSTA, AITSL) to observe teaching practices of student science teachers. Regarding the participants they were science students who enrolled in educational diplomas, researchers use the mixed method in collected data and quantitative data, furthermore, they will study a supportive program of considering data analyses to develop their teaching practices in teaching science, the results exposed that providing a supporting program that considers learning analytics, helps increase teaching practices in teaching science for student's science teachers.
Appraising the Impact of Critical Pipes on Water Loss Volume in WDNs considering Valve Effect

Water loss through leaking pipes is inexorable in water distribution networks (WDNs). Due to the increasing level of background losses in the WDNs, water loss is recognized as a major challenge facing the operation of municipal water services. Background leakage (a form of water loss) are diffuse flow, overtime, it causes significant loss of volume of water in WDNs. Nevertheless, the leak flow can be managed by adjusting the pressures along the pipe. In most cases, the average pressures in some specific areas where these pipes are located are adjusted. To achieve this, it is necessary to identify pipes having a relatively high level of background leakage. These pipes are regarded as critical pipes. Thus, this paper presents the effect of critical pipes in WDN. In addition, the impact of pressure reducing valves on the water loss level is discussed. The results presented indicate that the impact of the critical pipes on the overall network leakage water flow is huge.
On the Energy Performance of an Innovative Green Roof in the Mediterranean Climate

Green roofs have a thermal insulating effect known since ancient times. In the building sector, green roofs represent a sustainable passive solution to obtain energy savings, both during winter and summer. Moreover, they are a natural barrier against noise pollution, reducing sound reflections, and they contribute to clean air and biodiversity in urban areas. In this research, a roof-lawn system was studied through a long experimental campaign. Heat-flow meters, air and surface temperature sensors were used in two buildings characterized by different surrounding conditions, geometries and orientations. In both case studies, the thermal behaviors of the roof-lawn system were compared with the conventional roofs. In addition, a dynamic simulation model was created in order to quantify the effect of this green system on the heating and cooling energy demands. The roof-lawn showed a high thermal inertia, with no overheating during summer, and a high insulating capacity, involving energy savings during winter, and consequently better indoor thermal conditions.
Effet d’agonistes de PPARβ sur l’expression du VEGF (Vascular Endothelial Growth Factor) et des cadhérines E et N dans des modèles de cancers épithéliaux

Le potentiel invasif et metastatique d'une tumeur est controle par l'angiogenese via le VEGF (Vascular Endothelial Growth Factor) et les alterations des systemes impliques dans l'adherence cellulaire via les cadherines. Dans ce travail, nous montrons que le L-165041, agoniste du recepteur nucleaire PPARβ (Peroxisome Proliferator-Activated Receptor) regule l'expression du VEGF dans des cellules derivees de cancer du col de l'uterus dont le facteur etiologique est un papillomavirus (HPV). Cependant, cet effet est observe uniquement dans des cellules HPV18 independamment de l'oncoproteine virale E6 et de sa cible p53. De facon interessante, a la diflerence de ce que nous observons dans des cellules de cancer vesical, le L- 165041 ne controle pas la transcription mais stabilise les messagers des isoformes du VEGF (VEGF121, VEGF165, VEGF189) independamment du recepteur PPARβ. La stabilisation des ARNm VEGF necessite la phosphorylation de la p38 MAPK qui conduit, seule ou suite a une cascade de phosphorylations, au deplacement de la proteine HuR du noyau vers le cytoplasme et in fine a la stabilisation des ARNm VEGF. D'autre part, l'agoniste du PPARβ interviendrait dans la« transition epithelio-mesenchymateuse » de cellules urotheliales malignes, puisqu'une augmentation de l'expression de la cadherine E (marqueur epithelial) et une diminution de l'expression de la cadherine N (marqueur mesenchymateux) sont observees selon le phenotype cellulaire. Elucider le mecanisme moleculaire d'action des agonistes de PPARβ est d'un interet crucial puisque certains ligands sont en cours d'evaluation clinique pour le traitement de maladies metaboliques (dyslipidemies diabete de tvpe II).
Das Vorkommen von Artgemischen bei pflanzenparasitaren Nematoden. [English title not available]

The author has investigated the occurrence of mixtures of two or more species of a genus at the same place for six genera of plant-parasitic nematodes (Heterodera, Pratylenchus, Paratylenchus, Tylenchorhynchus, Rotylenchus and Meloidogyne), and shows how one species may become dominant as a result of a particular cropping or soil type, and may be subsequently suppressed by a change in environment. J.J.H.
Bcl11b is a Newly Identified Regulator of Vascular Smooth Muscle Phenotype and Arterial Stiffness

B-cell leukemia 11b (Bcl11b) is a zinc-finger transcription factor known as master regulator of T lymphocytes and neuronal development during embryogenesis. Bcl11b-interacting protein COUP-TFII is required for atrial development and vasculogenesis, however a role of Bcl11b in the adult cardiovascular system is unknown. A genome-wide association study (GWAS) recently showed that a gene desert region downstream of BCL11B and known to function as BCL11B enhancer harbors single nucleotide polymorphisms (SNPs) associated with increased arterial stiffness. Based on these human findings, we sought to examine relations between Bcl11b and arterial function using mice with Bcl11b deletion. We report for the first time that Bcl11b is expressed in vascular smooth muscle (VSM) and transcriptionally regulates the expression of VSM contractile proteins smooth muscle myosin and smooth muscle α-actin. Lack of Bcl11b in VSM-specific Bcl11b null mice (BSMKO) resulted in increased expression of Ca++-calmodulin-dependent serine/threonine phosphatase calcineurin in BSMKO VSM cells, cultured in serum-free condition, and in BSMKO aortas, which showed an inverse correlation with levels of phosphorylated VASPS239, a regulator of cytoskeletal actin rearrangements. Moreover, decreased pVASPS239 in BSMKO aortas was associated with increased actin polymerization (F/G actin ratio). Functionally, aortic force, stress and wall tension, measured ex vivo in organ baths, were increased in BSMKO aortas and BSMKO mice had increased pulse wave velocity, the in vivo index of arterial stiffness, compared to WT littermates. Despite having no effect on baseline blood pressure or angiotensin II-induced hypertension, Bcl11b deletion in VSM increased the incidence of aortic aneurysms in BSMKO mice. Aneurysmal aortas from angII-treated BSMKO mice had increased number of apoptotic VSM cells. In conclusion, we identified VSM Bcl11b as a novel and crucial regulator of VSM cell phenotype and vascular structural and functional integrity.
Contribution of using mobile application on botanical fieldwork in primary school

ABSTRACT The aim of the research is to examine the contribution of mobile application using in botanical fieldwork to the quality and durability of knowledge of the subject Nature and society compared to multimedia teaching in the fourth grade of primary school. The study involved 120 students, divided into two groups: control group, which taught on the principles of multimedia teaching with the help of digital herbarium and experimental group, which taught through botanical fieldwork, with the help of the mobile application PlantNet Plant Identification. A digital herbarium was placed on student’s computer at school (in the computer classroom) and at home, and a mobile application on every student’s mobile phone. Students studied and identified 30 plants, 13 forest and 17 cultivated plants. After the identification of the plants, the quality of students’ knowledge was examined by a post-test, while the durability of knowledge was examined by a re-test. The results of the research showed that using of the mobile application in botanical fieldwork contributed to the higher quality and durability of students’ knowledge compared to multimedia teaching at cognitive levels: analysis, evaluation and synthesis.
First documented record of Neocrex erythrops (Sclater, 1816) (Aves, Rallidae) from Rio Grande do Sul, southern Brazil

We present the first documented record of Neocrex erythrops (Sclater, 1816) from Rio Grande do Sul, southern Brazil. An adult male was found dead near the campus buildings at the Universidade de Caxias do Sul, Rio Grande do Sul, Brazil. The individual was collected and is vouchered in the zoological collection of the Museu de Ciências Naturais da Universidade de Caixas do Sul. This new record is the first documented occurrence of this species in Rio Grande do Sul.
Non-equilibrium interplay between gas-particle partitioning and multiphase chemical reactions of semi-volatile compounds: mechanistic insights and practical implications for atmospheric modeling of PAHs

Abstract. Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic air pollutants. The dispersion of PAHs in the atmosphere is influenced by gas-particle partitioning and chemical loss. These processes are closely interlinked and may occur at vastly differing timescales, which complicates their mathematical description in chemical transport models. Here, we use a kinetic model that explicitly resolves mass transport and chemical reactions in the gas and particle phases to describe and explore the dynamic and non-equilibrium interplay of gas-particle partitioning and chemical losses of PAHs on soot particles. We define the equilibration timescale τeq of gas-particle partitioning as the e-folding time for relaxation of the system to the partitioning equilibrium. We find this metric to span seconds to hours depending on temperature, particle surface area and the type of PAH. The equilibration time can be approximated using a time-independent equation τeq a 1/(kdes + kads), which depends on the desorption rate coefficient kdes and adsorption rate coefficient kads, both of which can be calculated from experimentally-accessible parameters. The model reveals two regimes in which different physical processes control the equilibration timescale: a desorption-controlled and an adsorption-controlled regime. In a case study with the PAH pyrene, we illustrate how chemical loss can perturb the equilibrium particulate fraction at typical atmospheric concentrations of O3 and OH. For the surface reaction with O3, the perturbation is significant and increases with the gas-phase concentration of O3. Conversely, perturbations are smaller for reaction with the OH radical, which reacts with PAHs on both the surface of particles and in the gas phase. Global and regional chemical transport models typically approximate gas-particle partitioning with instantaneous equilibration approaches. We highlight scenarios in which these approximations deviate from the explicit-coupled treatment of gas-particle partitioning and chemistry presented in this study. We find that the discrepancy between solutions depends on the operator-splitting time step and the choice of time step can help to minimize the discrepancy. The findings and techniques presented in this work are not only relevant for PAHs, but can also be applied to other semi-volatile substances that undergo chemical reactions and mass transport between the gas and particle phase.
Bowel Damage at Diagnosis Using the Lémann Index Score in Saudi Arabian Patients With Crohn's Disease

Background Advanced bowel damage caused by Crohn’s disease (CD) in the form of strictures and penetrating lesions has been associated with future surgical resection. However, in general, the degree of bowel damage in patients with CD is not examined at the time of diagnosis, and the natural history of CD may differ phenotypically between patients from Arabic countries as compared to patients from Europe and North America. Thus, we aimed to assess the degree of structural bowel damage in Saudi Arabian CD patients at diagnosis. We used the Lémann Index (LI) score, an instrument that measures cumulative digestive tissue damage by magnetic resonance enterography (MRE) and endoscopy, to establish any possible association between the duration of symptoms and the degree of bowel damage. Method This retrospective study was conducted by reviewing the data of all CD patients following up at King Abdulaziz University Hospital (KAUH) that were investigated by endoscopy and MRE at baseline. MRE-LI was calculated by scoring previous surgery, disease location and extension, and intestinal complications. A LI score of >2.0 was set as the cut-off point for bowel damage. Descriptive statistics were used to provide an overview of demographic and clinical characteristics, and hypothesis testing was applied to identify associations. Result Eighty-three patients with CD were included in this study. Fifty point six percent (50.6%) of the cohort comprised females and the median age was 27 years. With regards to CD location and extension, 34.9% showed ileal disease (L1), 9.6% showed colonic CD (L2), whereas 55.4% had ileocolonic involvement (L3). Moreover, 48.2% of patients presented with non-complicated behavior (B1), 25.3% had at least one stricture (B2), and 26.5% showed a penetrating phenotype (B3). Perianal CD was observed in 2.4% of subjects and 62.7% had undergone bowel resection. Mean LI was 2.4 (±2.6) with 34 patients (39.8%) exhibiting an LI score indicative of advanced bowel damage at the time of diagnosis. The duration of symptoms did not correlate with the degree of bowel damage according to the LI score. Conclusion A significant proportion of patients with CD presented with advanced bowel damage at the time of diagnosis, suggesting that a severe form of CD may be endemic in Saudi Arabia.
Computational aspects towards understanding the photoprocesses in eumelanin

Eumelanin is the active ingredient in skin pigment found in human beings. It is also present in animals, plants, and some bacteria and fungi. However, there are still open questions about its biological activity. The detailed molecular mechanism of its photoprotective property is topic of intense research. While it has been implicated in photo‐damage in certain conditions, the extent of this effect is largely unknown. Furthermore, its involvement in a wide range of metal chelation and radical scavenging properties remain unclear. This rather sparse knowledge about such as important biological system is mainly due to the extreme level of heterogeneity in eumelanin structure, its low solubility, and lack of unique structural features. Due to these difficulties theoretical studies and modeling appear to be a crucial cornerstone towards the understanding of eumelanin system. This review aims to report the current status of the understanding in molecular mechanism of photoprocesses in eumelanin and the theoretical approaches that are used for that. Furthermore, the outstanding open questions and difficulties in understanding the eumelanin system will be dealt with.
Impact of the perceived risk from Covid-19 on intention to travel

ABSTRACT The objective of this study is to analyse the impact of perceived risk on intention to travel in the Covid-19 pandemic situation. Applying the Theory of Planned Behaviour, the study addresses the modulating effects of risk on the antecedents of intention; additionally, the resulting model includes the impact of this intention on the willingness to pay (WTP) more to benefit from additional safety measures at the destination. Furthermore, this paper addresses respondents belonging to an at-risk group for Covid-19 as a source of heterogeneity that may exert an effect on the results of the model. The model is tested using PLS-SEM, and the empirical results can contribute to the development of safety measures in tourism services and the design of effective actions to restore tourism.
User Behavior on Online Social Networks: Relationships among Social Activities and Satisfaction

Social networking sites (SNSs) are now ubiquitous communities for constant online interpersonal interactions that trigger symmetric or asymmetric effects on our everyday life. Recent studies advocate in favor of the significant role that SNSs have in promoting well-being and, more importantly, in disseminating reliable information during a global crisis, such as the current COVID-19 pandemic. Based on the growing importance of SNSs to the global framework, the main purpose of this study is to empirically assess the link between the use of symmetric social networks such as Facebook, or asymmetric social networks, like Instagram, and the level of satisfaction, employing the methodology of structural equation modeling. The results of the research validate the hypothesis that SNS activities increase the level of satisfaction, and therefore, that there is a direct link between the number of posts and comments and the level of satisfaction. Furthermore, based on the reversible and significant link between the level of satisfaction and the importance attributed to SNSs, the main conclusion of the study is that the higher the importance of the SNS, the greater the level of dissatisfaction experienced by users. Also, public activities on social networks positively affect social network satisfaction, while private activities have a direct negative relationship with the importance of social networks.
The differences in carbon dynamics between boreal dwarf shrubs and Scots pine seedlings in a microcosm study

The ground level of boreal pine forests consists of a dense layer of ericaceous shrubs, herbs, grasses, mosses and lichens. The primary productivity of this forest floor vegetation is notable but the role the most common ericoid dwarf shrub plant species, Calluna vulgaris, Vaccinium myrtillus and Vaccinium vitis-idaea, play in carbon (C) cycling in these ecosystems is poorly understood. Here, we studied their C dynamics in detail using plants of similar size (age 14–19 months) in a microcosm study. We determined the full C balances of these dwarf shrubs for the first time and compared them to those of Pinus sylvestris by using long-term biomass accumulation, ¹³C pulse labelling and CO₂ exchange measurements in a controlled laboratory experiment. Pinus sylvestris had significantly higher biomass-based C fluxes than dwarf shrubs, both aboveground and belowground, but the dwarf shrubs did not differ in the biomass-based fluxes. We showed that root respiration of the evergreen ericoid dwarf shrubs was sensitive to the aboveground light conditions as belowground respiration was 50–70% higher under light compared with dark conditions. Such light-related differences were not observed for Scots pine. The observed differences in C dynamics are important in estimating the origin of belowground CO₂ fluxes and in evaluating their biological relevance. Our results improve current understanding of CO₂ sources and sinks in boreal ecosystems.
Equivalent circuit modeling on defect-dipole enhanced dielectric permittivity

Enhanced permittivity (EP) is always sought for dielectric-related applications, and its origin is thus extremely significant but has been long debated. The most extensively accepted mechanism of EP refers to the interfacial polarization effect which is usually recognized through equivalent circuit (EC) modeling. Nevertheless, the resulting circuit parameters are sometimes unreasonable and, moreover, the EC models representing the bulk/grain response of defect-dipole enhanced permittivity are still lacking. To this end, a new EC model describing the bulk/grain polarization associated with defect-dipole relaxation is proposed in this work and is verified in (Li,In)-doped MgO and (In + Ta)-doped TiO2. EP is achieved in (Li,In)-doped MgO and clearly does not satisfy the interfacial polarization effect described by the classical brick EC model. Instead, the proposed EC model, which captures the features of UDR (universal dielectric response) power-law dependence and non-Debye response, not only separates the contributions from the defect-dipoles and matrix to the total dielectric response, but also reveals the respective dynamics. The EC model is further validated in the classical EP material (In + Ta)-doped TiO2. The established EC model is thus helpful to understand a broad class of dielectric systems with defect-dipole relaxation and to design new materials with EP.
Analysis of Telomere Healing of DNA Double-strand Breaks

DNA double-strand breaks (DSBs) are a threat to cell survival and genome integrity. In addition to canonical DNA repair systems, DSBs can be converted to telomeres by telomerase. This process, herein termed telomere healing, endangers genome stability since it usually results in chromosome arm loss. Therefore, cells possess mechanisms that prevent the untimely action of telomerase on DSBs. In this work, I reported the completion of a transposon mutagenesis screen in budding yeast and the identification of five novel genes (RRD1, CIK1, CTF18, RTS1, and IRC6) critical for telomere healing. The characterization of Rrd1 led to the surprising finding that Rrd1 facilitates telomere healing at DSBs with little or no TG-rich sequences but not at DSBs with long tracts of telomeric sequences. Pph3, a PP4 phosphatase, acts in conjunction with Rrd1 to promote telomere healing. Conversely, Mec1, the ATR ortholog, phosphorylates Cdc13 on its S306 residue to suppress its accumulation at DSBs. Rrd1 and Pph3 oppose Cdc13 S306 phosphorylation and are necessary for the efficient accumulation of Cdc13 at DSBs. Next, I found that Cik1 and its kinesin partner Kar3 are both important for telomere healing. Importantly, Kar3 contributes to telomere healing through its motor function. In contrast to Rrd1, Kar3 contributes to telomere healing regardless of telomeric sequence lengths adjacent to the break. Finally, Cik1 and Kar3 have a general role in DNA repair and physically associate with DSBs, which is dependent on the process of anchoring DSBs to nuclear periphery. In conclusion, I identified a mechanism by which the ATR family of kinases enforces genome integrity, a phosphoregulatory loop that underscores the contribution of Cdc13 to the fate of DNA ends, and a kinesin complex critical for the spatial organization of DNA repair.