Miracle-dz/UniFAR-FTUs huggingface dataset:
Smallpox in the Post-Eradication EraHermann Meyer1

Widespread vaccination programmes led to the global eradication of smallpox, which was certified by the World Health Organisation (WHO), and, since 1978, there has been no case of smallpox anywhere in the world. However, the viable variola virus (VARV), the causative agent of smallpox, is still kept in two maximum security laboratories in Russia and the USA. Despite the eradication of the disease smallpox, clandestine stocks of VARV may exist. In a rapidly changing world, the impact of an intentional VARV release in the human population would nowadays result in a public health emergency of global concern: vaccination programmes were abolished, the percentage of immunosuppressed individuals in the human population is higher, and an increased intercontinental air travel allows for the rapid viral spread of diseases around the world. The WHO has authorised the temporary retention of VARV to enable essential research for public health benefit to take place. This work aims to develop diagnostic tests, antiviral drugs, and safer vaccines. Advances in synthetic biology have made it possible to produce infectious poxvirus particles from chemicals in vitro so that it is now possible to reconstruct VARV. The status of smallpox in the posteradication era is reviewed.
Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?

Background Increased dehydroepiandrosterone sulfate (DHEAS) levels have been reported in men with early-onset (<35 years) androgenetic alopecia (AGA). It has been suggested that a male polycystic ovarian syndrome- (PCOS-) equivalent, defined as an endocrine syndrome with a metabolic background and a PCOS-like hormonal pattern, predisposing to type II diabetes mellitus (DM II), cardiovascular and prostate diseases later in life, may occur in at least a part of these men. The gonadal function, including sperm parameters and total testosterone (TT) levels, has been investigated in a low number of these men. Objective The aim of the study was to assess gonadal and adrenal function in a subset of men with early-onset AGA and controls. Methods 43 men with early-onset AGA and 36 controls were screened for DHEAS, TT, glycaemia, insulin, gonadotropins, 17α-hydroxyprogesterone (17α-hydroxyprogesterone (17n = 21), as those with at least one of the following parameters: body mass index (BMI) >25 kg/m2, insulin resistance (IR), and/or SHBG <25 nmol/l. Results Patients with early-onset AGA had higher mean (±SD) BMI (25.5 ± 3.8 vs. 23.7 ± 3.0 kg/m2; P < 0.05) and 17α-hydroxyprogesterone (17P < 0.05) and 17P < 0.05) and 17P < 0.05) and 17P < 0.05) and 17μg/dl; P < 0.05) and 17P < 0.05) and 17P < 0.05) and 17P < 0.05) and 17 Conclusion Men with early-onset AGA and at least one among BMI >25 kg/m2, IR, and SHBG <25 nmol/l have increased DHEAS levels and a worse gonadal steroidogenesis. They might have a greater risk to develop gonadal dysfunction later in life. These criteria may be used to define male PCOS-equivalent.
Indigenous Andean Root and Tuber Crops: New Foods for the New Millennium

The best known ARTCs include arracacha, achira, yacon, mauka, and ahipa from the interAndean valleys; and ulluco, oca, mashua, maca, and 8 potato species from the highlands. These crops are grown from southern Venezuela to northwestern Argentina with the highest varietal diversity and uses in the region between central Peru to central Bolivia. Table 1 presents basic botanical information and current uses of these ARTCs.
Eixo Temático: Estratégia e Internacionalização de Empresas BRAZILIAN EXCHANGE TRADED FUNDS (ETFS) PRICING EFFICIENCY: LONG TERM ANALYSIS BASED ON COINTEGRATION WITH MARKOV REGIME SWITCHING EFICIÊNCIA DE PRECIFICAÇÃO DE EXCHANGE TRADED FUNDS BRASILEIROS (ETFS): ANÁLISE DE LONGO PRAZO COM BAS

Exchanged Traded Funds (ETFs) are a wide-spread investment vehicle, with characteristics that have not been sufficiently studied yet, especially in emerging markets. Consolidated asset pricing models are not enough to thoroughly analyze the dynamics of share prices variation and their relationship with net asset value and the market, a special feature of investment funds with exchange traded shares. The objective of this study is to analyze the pricing efficiency of Brazilian ETFs, based on the long-term relationship between share prices and the market index, as well as share prices and the ETFs net asset value (NAV). We estimated the cointegration with Markov switching between Brazilian ETFs share prices and Ibovespa index and the cointegration between Brazilian ETFs share prices and their NAV, analyzing their behavior during 2004-2012. The error generated by the cointegration is analogous to the traditional measures of pricing deviation. Our results pointed that the error of the first estimation is stationary, but the second is not, indicating that the share prices and the NAV are not cointegrated. Considering that during crisis periods the ETFs trade at discounts, but they 5o FÓRUM INTERNACIONAL ECOINOVAR 1a CONFERÊNCIA INTERNACIONAL DE SUSTENTABILIDADE E INOVAÇÃO Santa Maria/RS – 9 a 12 de Agosto de 2016 2 are cointegrated with the market in the long run, there may be arbitrage opportunities that the investors could take benefit, buying the ETFs in crisis periods and selling them after that the market recover.
Influence of Pre-Harvest Factors on Postharvest Quality of Fresh-Cut and Baby Leafy Vegetables

Shelf life of horticultural commodities is dependent on postharvest handling but also on a wide range of pre-harvest factors, which include genetic and environmental parameters. This study was conducted to explore the influence of cultivar, leaf position, and piece position on the leaf on visual quality of fresh-cut butterhead lettuce as well as the effect of a wide range of cultivation seasons on the postharvest quality and shelf life of baby leaves (spinach and ‘wild’ rocket). Six butterhead lettuce cultivars were used (cultivated soilless in an unheated plastic greenhouse) while the effect of leaf position on the plant (outer and inner leaves) and the piece position on the leaf (piece one close to the leaf base and piece four close to the top) were also evaluated. Baby leaves were cultivated under an unheated plastic greenhouse for winter production and under a nethouse for the rest of the growing season, with a total of five and seven sampling dates for spinach and ‘wild’ rocket respectively. The cultivar of butterhead lettuce had a significant effect on postharvest quality of fresh-cut product but more important was the piece position on the leaf. When this was closer to the base of the leaf, there was more browning on cut edges and limited shelf life for the fresh-cut lettuce. The result was associated in one tested cultivar with PAL activity, which was higher by 106% for piece one compared to piece four as an average for the whole storage period. The growing season of baby leaves had a great impact on their shelf life, with the season of mild environmental conditions achieving the highest marketability.
Evaluation of the effects of octreotide on portal hemodynamics using pulsed doppler ultrasonography in patients with chronic liver disease

Intensive clinical investigations on Somatostatin have been being carried out in recent years. Somatostatin and its synthetic analogues were initially used in the treatment of endocrine tumors. Today, they are being studied in the treatment of gastrointestinal diseases and successful results are being obtained. 20 chronic liver disease (CLD) patients (10 chronic active hepatitis (CAH) and 10 cirrhosis), and 10 controls were included in this study. Effects of Octreotide on portal venous flow velocity were investigated using Pulsed Doppler technique. All the patients were given 100 meg Octreotide (SC), after the determination of baseline values of blood pressure; pulse rate; blood glucose, urea, creatinin, Na, K and portal venous flow velocity. These criteria were determined again in the 15, 30, 45, 60, 120 and 180th minutes after the injection. In the patients with CAH, portal venous flow velocity was changed from 11.8+2.6 cm/sec. to 9.9+2.5 cm/sec. in the 15th min. (p<0.01); to 8.7+1.9 cm/sec. in the 30th min. (p<0.01); to 8.6+2.1 cm/sec. in the 45th min. (p<0.01); to 8.7+2.0 cm/sec. in the 60th min. (p<0.01); to 9.0+2.2 cm/sec. in the 120th min. (p<0.05); and to 9.1+2.3 cm/sec. in the180th min. (p<0.05). In the cirrhotic patients and in controls, portal venous flow velocity showed similar changes and we observed that the efficacy of the drug continued until the 180 th minute. The results of this study revealed that Octreotide had caused reduction in portal venous flow velocity with a rate of 30-35 % in controls, and 20-25 % in patients with CLD.
Mathematical Modelling and Optimisation of Low-Temperature Drying on Quality Aspects of Rough Rice

Rice when harvested normally has a high moisture content of 20–25% which requires immediate drying, reducing its mass loss and preventing it to spoil. This situation is more crucial with the areas under humid tropical conditions, where moisture and temperature mainly play an important role in deteriorating the quality of rough rice. Keeping the importance of quality attributes of rough rice, the study was carried out to assess the effects of low-temperature drying and suggest an optimum condition. Response surface methodology (RSM) with a central composite design was employed to study the effects of variables, i.e., temperature (X1), time (X2), and air velocity (X3) on responses, i.e., head rice yield (HRY), hardness, lightness, and cooking time. The experimental data were fitted to the quadratic model, studying the relationship between independent and dependent variables. The results revealed that the HRY, hardness, lightness, and cooking time increased with increasing variables, whereas for HRY, it particularly increased and then decreased. It was observed that temperature had more influence on the quality of rough rice followed by time and velocity. Results for analysis of variance revealed that the quality aspects of rough rice were significantly ( ) affected by temperature and time, whereas for velocity, it only significantly affected hardness. The optimal drying conditions predicted by RSM for variables were 25°C, 600 min, and 1 m·s−1, and the optimal predicted HRY, hardness, lightness, and cooking time were 73.93%, 38.28 N, 71.40, and 27.58 min respectively. Acceptable values of R2, Adj R2, and nonsignificance of lack of fit demonstrated that the model applied was adequate and can be used for optimization. The study concluded that the RSM with a central composite design was successfully used to study the dependence of quality aspects of rough rice at low temperature and can be utilized by the rice processing industries.
Transforming the Swiss Mobility System towards Sustainability

1 Mapping potential options and barriers for transformation The transport sector is responsible for about 1/3 of the Swiss CO2 emissions (BAFU, 2017, p. 17) and 1/3 of the Swiss final energy consumption (BFE, 2016, p. 3). Despite the anticipation of emission reductions in other sectors such as households or industry, no decline is expected in the transport sector in the next years (Betschart et al., 2016). It is a goal, also regarding the Swiss Energy Strategy 2050, to reduce the energy consumption and the CO2 emissions of the transport sector, which requires a broad transformation of the mobility system.
WHO EMRO | Socioeconomic inequality in smoking and its determinants in the Islamic Republic of Iran

Background: The role of socioeconomic inequality and related factors has not been well reported in tobacco consumption. Aims: To investigate the socioeconomic inequality in smoking and its associated factors in the Islamic Republic of Iran. Methods: Data were collected from surveillance for noncommunicable diseases in 2005, which included 89 404 people aged 15–65 years. Economic status was defined by principal component analysis on variables related to socioeconomic status. Concentration index and slope index of inequality were used to determine the inequality value. The gap between the high and low economic status groups was decomposed using the Oaxaca–Blinder decomposition method for explained and unexplained components. Results: The total prevalence of smoking was 17.0%; 28.0% in males, and 5.8% in females, 15.8% in urban and 19.1% in rural areas. The concentration index was –0.032 in the whole of country; –0.098, in males, –0.246 in females, 0.014 in urban and –0.059 in rural areas and varied in different provinces of country. The smoking rate was 18.0% for the first quintile and 13.5% for the fifth quintile, a gap of 4.5%. The major part of this gap was related to differences in education level, sex, marital status and age in economic groups.
Crowd Discussion for the Future of Your Hometown: An Agent-based Crowd Discussion Support System

Discussion among many people is important and essential for SDGs and democary. Providing good support is critical for establishing and maintaining coherent discussions. Large-scale online discussion platforms are receiving great attention as potential next-generation methods for smart democratic citizen platforms. Such platforms require support functions that can efficiently achieve a consensus, reasonably integrate ideas, and discourage flaming. We are developing several crowd-scale discussion platforms and conducting social experiments. In the initial version for such system, we employed human facilitators in order to achieve good disucssion. However, we clarified the critical problems faced by human facilitators caused by the difficulty of facilitating crowd-scale online discussions. In this work, we propose an automated facilitation agent[Ito and Shiramatsu, 2018] to manage online discussions. An automated facilitator agent extracts the discussion structure from the texts posted in discussions by people. In this paper, we present our current implementation of a crowd-scale discussion support system based on an automated facilitation agent, which extracts discussion structures from text discussions, analyzes them, and posts facilitation messages. We conducted a large-scale social experiment with Nagoya City ’s local government in which our automated facilitation agent worked well.
Soil Properties and Mineral Nutrients of Clementine Mandarine (Citrus reticulata Blanco) Grown in the Koycegiz Region of Mugla Province

Soil properties of the samples from orchards and the nutrients (macro- and microelements) in the clementine mandarin ( Citrus reticulata Blanco), widely grown in the Koycegiz region of Mugla Province Turkey, were studied. Mandarin tree leaves and soil samples were collected from 10 different orchards. The soil samples were analyzed for its pH, CaCO 3 , EC, sand, organic matter, nitrogen (N), phosphorus (P), potassium (K), calcium (Ca), magnesium (Mg), iron (Fe), zinc (Zn), manganese (Mn), copper (Cu) and boron (B) while leaves were analyzed for its macro- and microelements. The results obtained from soil analysis showed suitable amount of calcium carbonate and EC. Analysis of the soil showed that organic matter, N, K and Mn were insufficient in all orchards, while Fe was higher in amount. Slight alkaline, strong alkaline and neutral pHs were determined in the orchards. Besides, the leaf samples collected from the orchards reflected deficient amount of N and Ca while higher amount of Mg and Fe.
DC_TEL: Framework for assisting the data production and analysis in TEL

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. DC_TEL: Framework for assisting the data production and analysis in TEL Nadine Mandran, Isabelle Girault, Cédric Ham
Multi-Entry Functions in LLVM

This project describes the implementation of a novel programming language feature — Multi-Entry Function — in the LLVM compiler backend. A Multi-Entry Function is a generalization of the Function feature of programming languages; unlike a Function, which restricts the program to jump into its body from only a single pre-defined entry point, a Multi-Entry Function allows the program to jump into its body through multiple pre-defined entry points.
THE EMERGENCE OF CHINA: IMPACTS ON THAILAND AND ASEAN AND THE ROLE OF JAPAN

This paper focuses upon the impacts of the emergence of China. Impacts on ASEAN as well as the competitive challenges and opportunities for Thailand are discussed. It is suggested that ASEAN needs to revitalize its competitiveness by pushing ahead with deeper integration to make ASEAN into an integrated trading and production region. This will enable ASEAN to increase competitiveness by exploiting its fairly large size. The role of Japan in this process is particularly important. The large Japanese production presence in ASEAN through past foreign direct investment makes it mutually beneficial that ASEAN regains its competitiveness and dynamism.
Control of sheared flow stabilized Z-pinch plasma properties with electrode geometry

geometry E.L. Claveau, U. Shumlak, B.A. Nelson, A.D. Stepanov, Y. Zhang 1 University of Washington, Seattle, USA Introduction The Fusion Z-pinch Experiment (FuZE) produces a 0.3 cm radius by 50 cm long Z-pinch between the end of the inner electrode of a coaxial plasma gun and an end wall 50 cm away. The plasma column is stabilized for thousands of instability growth times by an embedded radially-sheared axial plasma flow, a method proposed in [1] and demonstrated experimentally in other sheared flow-stabilized Z-pinch devices, ZaP and ZaP-HD [2]. Temperatures of 1-2 keV and peak densities of 1 × 10 m are obtained in a 200 kA Z-pinch sustained for 5-8 μs. Recently, FuZE demonstrated sustained generation of neutrons over thousands of instability growth times [3], suggesting its viability as a thermonuclear power plant for a future device operating at higher current.
Evaluation of Serious Game User Experience: the Role of Emotions

Serious games are slowly becoming a part of educational systems and corporate training facilities in lots of fields such as industry, health, management, etc. Despite this, the academic knowledge on these artefacts is still limited. The research reported in this paper examined emotional implications of serious games on the user experience. This correlational research observed the relationships between factors of serious gaming and emotions. Fifty students took part in the study. The participants used a serious game on the security of an Information System and answered a structured questionnaire. The data was analysed by Spearman’s correlation. The results show that the quality components of the multimedia system and the quality of the content of the game are correlated with emotions, satisfaction and intention to use. Moreover, they show that emotions are correlated with satisfaction, learning and success of the serious game. Satisfaction and learning play a key role in these programs. If serious game training is to have some efficiency, a deeper understanding of the factors that lead to the success of these applications is required. These factors are all levers of control that affect the perception and emotions of the user. Understanding these mechanisms could eventually lead to more effective serious games.
Inventory prediction and management in Nigeria using market basket analysis associative rule mining: memetic algorithm based approach

A key challenge in businesses today is determining inventory level for each product (to be) sold to clients. A pre-knowledge will suppress inventory stock-up and help avert unnecessary demurrage. It will also avoid stock out and avert loss of clients to competition. Study aims to unveil customer’s behavior in purchasing goods and thus, predict a next time purchase as well as serve as decision support to determine the required amount of each goods inventory. Study is conducted for Delta Mall (Asaba and Warri branches) department store. We adapt the memetic algorithm on market basket dataset to examine buying behavior of customers, their preference and frequency at which goods are purchased in common (basket). Result shows some items placed in basket allow customers to purchase items of similar value, or best combined with the selected items due to shelf-placement via concept of feature drift. Model yields 21-rules for eight items obtained from data transaction mining dataset acquired from Delta Mall.
Autonomous Robotics Competition Club (ARCC)

I n this paper, the technical approach to achieve the objectives for the indoor and outdoor missions of the International Micro Air Vehicle (IMAV) competition are presented. The ARCC team plans to utilize a single drone for the indoor competition and multiple drones to achieve the outdoor mission objectives. A scaled up version of the indoor drone would be utilized for the outdoor competitions to increase endurance and carry a larger sensor payload. A fully autonomous and primarily vision focused approach was taken for both missions with all computations being performed on-board excluding the 2D mapping which is performed off-board for the outdoor mission, whereas the indoor mission leverages off-board computing to reduce vehicle mass. Computer vision tasks are performed using a combination of the ZBar library for QR codes, semantic segmentation using the UNet architecture, object recognition using an RCNN, and classical image processing techniques such as ORB features and Hough transforms.
Seroprevalence of Human Betaretrovirus Surface Protein Antibodies in Patients with Breast Cancer and Liver Disease

Mouse mammary tumor virus (MMTV) is a betaretrovirus that plays a causal role in the development of breast cancer and lymphoma in mice. Closely related sequences that share 91–99% nucleotide identity with MMTV have been repeatedly found in humans with neoplastic and inflammatory diseases. Evidence for infection with a betaretrovirus has been found in patients with breast cancer and primary biliary cholangitis and referred to as the human mammary tumor virus and the human betaretrovirus (HBRV), respectively. Using the gold standard technique of demonstrating retroviral infection, HBRV proviral integrations have been detected in cholangiocytes, lymph nodes, and liver of patients with primary biliary cholangitis. However, the scientific biomedical community has not embraced the hypothesis that MMTV like betaretroviruses may infect humans because reports of viral detection have been inconsistent and robust diagnostic assays are lacking. Specifically, prior serological assays using MMTV proteins have produced divergent results in human disease. Accordingly, a partial HBRV surface (Su) construct was transfected into HEK293 to create an ELISA. The secreted HBRV gp52 Su protein was then used to screen for serological responses in patients with breast cancer and liver disease. A greater proportion of breast cancer patients (n = 98) were found to have serological reactivity to HBRV Su as compared to age- and sex-matched control subjects (10.2% versus 2.0%, P=0.017, OR = 5.6 [1.25–26.3]). Similarly, the frequency of HBRV Su reactivity was higher in patients with primary biliary cholangitis (n = 156) as compared to blood donors (11.5% vs. 3.1%, P=0.0024, OR = 4.09 [1.66–10.1]). While the sensitivity of the HBRV Su ELISA was limited, the assay was highly specific for serologic detection in patients with breast cancer or primary biliary cholangitis, respectively (98.0% [93.1%–99.7%] and 97.0% [93.4%–98.6%]). Additional assays will be required to link immune response to betaretrovirus infection and either breast cancer or primary biliary cholangitis.