Miracle-dz/UniFAR-FTUs huggingface dataset:
Pendidikan Gizi Tentang MP-ASI dengan Media Leaflet Pada Pengetahuan Ibu Balita Usia 6-24 Bulan di Posyandu Mawar Kelurahan Semanggi Surakarta

Background: The factor that influence the giving of MP-ASI is mother toddler’s knowledge. The first research has been shown that the mother toddler’s knowledge is less than 45%. One of the method that possible to do is nutrition education. Nutrition education about breastfeeding supplementary food in Posyandu requires media to deliver information to the mothers easily. Leaflet selected as nutrition education media because it is able to spread information in a short time so it hopes that after attending nutrition education using leaflet media can improve mother’s knowledge in Posyandu Mawar in Semanggi Village Surakarta. Objective: to know the effect of nutrition education about MP-ASI with leaflet media to knowledge of mother of toddler age 6-24 month in Posyandu Mawar Semanggi Village Surakarta. Methods: This research is descriptive research, variable is measured by using questioner before and after given nutrition education about complementary food of ASI. The media used is a leaflet. Results: The level of mother’s knowledge before being given nutrition education mostly (40,5%) included to enough, meanwhile mother toddler’s knowledge level after nutrition education has been good on more than half respondents (54,1%). Conclusion: There is influence before and after being given nutrition education about MP-ASI with media leaflet to knowledge of mother of toddler age 6-24 months at Posyandu Mawar in Semanggi Village Surakarta. Research Suggestion: Mother need to improve knowledge about the types of MPASI and nutrient content yag found in food to be provided.
Around the word stress: its biological and evolutive implications

Stress is a general adaptive reaction crucial for survival and basically positive that involves the neuroendocrine and the immune systems. In all bilaterian metazoans, the molecular mediators of the stress response, i.e., corticotrophin-releasing hormone, corticotrophin, catecholamines and glucocorticoids, have been preserved during evolution, even if the increased complexity of animals have corresponded to a more articulated stress response that, following the eco-immunology perspective, we speculate to be hierarchically organized along three levels.
A study to assess the level of death anxiety among elderly people at selected area at Bhopal

Objectives of the Study1.To assess the level of death anxiety among elderly people.2. To associate the level of death anxiety with the selected demographic variables.HypothesisH1: There will be significant level of death anxiety among elderly people.H2: There is significant association between levels of death with the selected demographic variables of the elderly people.
History of the invasion and distribution of Reynoutria taxa in the Czech Republic: a hybrid spreading faster than its parents.

The distribution of four alien Reynoutria taxa (R. japonica var. japonica, R. japonica var. compacta, R. sachalinensis and R. ×bohemica), native to East Asia, and history of their introduction to and spread in the Czech Republic was studied. The most widely distributed representative of the genus, R. japonica var. japonica, was first recorded in 1883 by A. Weidmann in cultivation in S Bohemia. The first record outside cultivation is from N Bohemia in 1902. Up to 2000, it has been recorded in 1335 localities, most frequently in riparian and human-made habitats. The dwarf variety R. japonica var. compacta is of a limited distribution that depends on rare cultivation and subsequent escape. The first herbarium specimen was collected in 1948 and the first record out of cultivation is from 1995. R. sachalinensis was recorded in 261 localities. It was first collected in 1921 in Central Bohemia. A herbarium specimen of a plant cultivated in the Botanical Garden of the Charles University in Prague, collected in 1950, has been re-determined as R. ×bohemica, the hybrid between R. japonica var. japonica and R. sachalinensis, and represents the earliest record of the hybrid in the Czech Republic. Since then, this taxon was observed in 381 localities. Herbarium records were used to compare the rate of spread among the three common taxa in 1952–1995, i.e. since when the hybrid started to appear in herbaria. R. japonica var. japonica has been spreading significantly faster than R. sachalinensis and the hybrid exhibits twice the rate of invasion of its parents.
Come Biopsiare Solo i Pazienti con Tumore Prostatico ad Alto Grado?

Introduction Fuzzy logic and Artificial Neural Networks (ANN) are complementary technologies that together generate neuro-fuzzy system. The aim of our study is to compare 2 models for predicting the presence of high-grade prostate cancer (Gleason score 7 or more). Methods We evaluated data from 1000 men with PSA less than 50 ng/mL, who underwent prostate biopsy. A prostate cancer was found in 313 (31%), and in 172 (17.2%) we detected high-grade prostate cancer. With those data, we developed 2 Co-Active Neuro-Fuzzy Inference Systems to predict the presence of high-grade prostate cancer. The first model had four input neurons (PSA, free PSA percentage [%freePSA], PSA density, and age) and the second model had three input neurons (PSA, %freePSA, and age). Results The model with four input neurons (PSA, %freePSA, PSA density, and age) showed better performances than the one with three input neurons (PSA, %freePSA, and age). In fact the average testing error was 0.42 for the model with four input neurons and 0.44 for the other model. Conclusions The addition of PSA density to the model has allowed to obtain better results for the diagnosis of high grade prostate cancer.
SIRS, CARS and MARS in relationship to cancer cachexia and its clinical implications

Cachexia is a syndrome characterized by continuous, involuntary weight loss and systemic inflammation. Several mediators that are either hostor tumor-derived, such as pro-inflammatory cytokines, have been implicated in the pathogenesis of cancer cachexia. The compensatory humoral system that typically reduces the excessive production of pro-inflammatory cytokines in order to maintain homeostasis is also highly activated in patients with cancer cachexia. The above observations, along with cachexia, suggest that conditions similar to SIRS (systemic inflammatory response syndrome) and CARS (compensatory anti-inflammatory response syndrome), or to mixed anti-inflammatory response syndrome (MARS), may exist in cachexia. The typical immunological status of patients with cancer cachexia has been demonstrated to be suppressed cell-mediated immunity, and a Th2-dominant condition and myeloid-derived suppressor cells: MDSCs are major causes of this suppression. Several therapies and strategies have been proposed with regard to anti-inflammatory treatments. However, no effective therapy against cancer cachexia is currently available. Further studies on the molecular mechanisms of inflammation, and the development of new anti-inflammatory agents, are required.
Major Impact of Sampling Methodology on Gene Expression in Estrogen Receptor–Positive Breast Cancer

Abstract To investigate the impact of sampling methodology on gene expression data from primary estrogen receptor–positive (ER+) breast cancer biopsies, global gene expression was measured in core-cut biopsies at baseline and surgery from patients randomly assigned to receive either two weeks of presurgical aromatase inhibitor (AI; n = 157) or no presurgical treatment (n = 56). Those genes most markedly altered in the AI group (eg, FOS, DUSP1, RGS1, FOSB) were similarly altered in the no treatment group; some widely investigated genes that were apparently unaffected in the AI group (eg, MYC) were counter-altered in the control group, masking actual AI-dependent changes. In the absence of a control group, these artefactual changes would likely lead to the most affected genes being the erroneous focus of research. The findings are likely relevant to all archival collections of ER+ breast cancer.
A Multiplex Assay for the Diagnosis of Mucopolysaccharidoses and Mucolipidoses

Introduction Diagnosis of the mucopolysaccharidoses (MPSs) generally relies on an initial analysis of total glycosaminoglycan (GAG) excretion in urine. Often the dimethylmethylene blue dye-binding (DMB) assay is used, although false-negative results have been reported. We report a multiplexed diagnostic test with a high sensitivity for all MPSs and with the potential to identify patients with I-cell disease (ML II) and mucolipidosis III (ML III). Methods Urine samples of 100 treatment naive MPS patients were collected and analyzed by the conventional DMB assay and a multiplex assay based on enzymatic digestion of heparan sulfate (HS), dermatan sulfate (DS) and keratan sulfate (KS) followed by quantification by LC-MS/MS. Specificity was calculated by analyzing urine samples from a cohort of 39 patients suspected for an inborn error of metabolism, including MPSs. Results The MPS cohort consisted of 18 MPS I, 16 MPS II, 34 MPS III, 10 MPS IVA, 3 MPS IVB, 17 MPS VI and 2 MPS VII patients. All 100 patients were identified by the LC-MS/MS assay with typical patterns of elevation of HS, DS and KS, respectively (sensitivity 100%). DMB analysis of the urine was found to be in the normal range in 10 of the 100 patients (sensitivity 90%). Three out of the 39 patients were identified as false-positive, resulting in a specificity of the LS-MS/MS assay of 92%. For the DMB this was 97%. All three patients with MLII/MLIII had elevated GAGs in the LC-MS/MS assay while the DMB test was normal in 2 of them. Conclusion The multiplex LC-MS/MS assay provides a robust and very sensitive assay for the diagnosis of the complete spectrum of MPSs and has the potential to identify MPS related disorders such as MLII/MLIII. Its performance is superior to that of the conventional DMB assay.
Revascularización coronaria sin circulación extracorpórea: Supervivencia alejada

: Although randomized clinical trials have compared the short-term results of coronary revascularization with on-pump vs. off-pump, the long-term survival effect of off-pump coronary surgery has not been analyzed. The aim of this study was to compare the long-term survival of patients with coronary surgery with off-pump technique. All patients that underwent coronary revascularization from November 1996 to March 2015 were included (n = 4687). We analyzed the long-term survival and the incidence of cardiac events between patients who received off-pump coronary revascularization (n = 3402) against those revascularized with on-pump technique (n = 1285). The primary endpoint was defined as death from any cause. To reduce potential biases, risk-adjusted analysis was performed (propensity score). In-hospital mortality and during follow-up (10 years) for both groups were analyzed. The overall hospital mortality was 3.1%. A statistically significant difference between groups in favor of off-pump surgery was observed (2.3% vs. 5.2%, p < 0.0001). In the survival analysis, off-pump surgery proved to have similar long-term survival as on-pump surgery (off-pump vs. on-pump: 77.9% ± 1.2% vs. 80.2% ± 1.3%, p log rank = 0.361); even in the adjusted survival analysis (84.2% ± 2.9% vs. 80.3% ± 2.4%, p = 0.169). In conclusion, off-pump coronary surgery was associated with lower in-hospital mortality; and it was not associated with increased long-term survival compared with on-pump surgery.
Increasing Physical Activity Using An Ecological Model

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Evaluation of HbA1c in The Diagnosis of Diabetes

Background: Diabetes has become a major health problem in India with the largest number of diabetic patient burden in the world. It is estimated that, this disease will assume epidemic proportions during the first quarter of the 21st century and by the year 2025, >75% of people with diabetes will reside in developing countries, as compared with 62% in 1995. We evaluated the clinical utility of HbA1c as the base line investigation along with plasma glucose estimation in hospitalized patients for diagnosis of diabetes mellitus. Methods: A total of 400 patients of more than 25 yrs were tested. All the patients were evaluated by a random plasma glucose estimation, plasma glucose fasting and 2h after 75 g of glucose and HbA1c. Result: Fasting plasma levels varied from 82mg/dl to 216 mg/dl A total of 11 patients had plasma glucose values in the diabetic range (>126mg/dl) Plasma glucose in these patients ranged from 129 to 216 mg/dl. Patients with diabetes had higher HbA1c levels than subjects without diabetes. We found that an HbA1c value =>6.5% was 100% (11/11) specific for the diagnosis of diabetes. Conclusion: HbA1c correlated well with fasting plasma glucose values. In clinical settings, this test would be preferred as a first line test for diagnosis of diabetes in our country as it is convenient for the patient.
Malaria, anaemia and undernutrition in a drought-affected area of the Rift Valley of Ethiopia: Experiences from a trial to prevent malaria

Background: This study was part of the work to prepare for a cluster‐randomized controlled trial to evaluate the effect of combining indoor residual spraying and long‐lasting insecticidal nets on malaria incidence. A pilot study was done to estimate the variations of malaria incidence among villages, combined with entomological collections and an assessment of susceptibility to insecticides in malaria vectors. Methods: A cohort of 5309 residents from four kebeles (the lowest government administrative unit) in 996 house‐ holds was followed from August to December 2013 in south‐central Ethiopia. Blood samples were collected by a fin‐ ger prick for a microscopic examination of malaria infections. A multilevel mixed effect model was applied to measure the predictors of malaria episode. Adult mosquitoes were collected using light traps set indoors close to a sleeping person, pyrethrum spray sheet catches and artificial outdoor pit shelters. Enzyme‐linked immunosorbent assays were used to detect the sources of mosquito blood meals, while mosquito longevity was estimated based on parity. The World Health Organization’s tube bioassay test was used to assess the insecticide susceptibility status of malaria vec‐ tors to pyrethroids and carbamates. Results: The average incidence of malaria episode was 4.6 per 10,000 person weeks of observation. The age group from 5 to 14 years (IRR = 2.7; 95 % CI 1.1–6.6) and kebeles near a lake or river (IRR = 14.2, 95 % CI 3.1–64) were sig‐ nificantly associated with malaria episode. Only 271 (27.3 %) of the households owned insecticide‐treated nets. Of 232 adult Anopheles mosquitoes collected, Anopheles arabiensis (71.1 %) was the predominant species. The average longevity of An. arabiensis was 14 days (range: 7–25 human blood index days). The overall human blood index (0.69) for An. arabiensis was higher than the bovine blood index (0.38). Statistically significant differences in Anopheline mos‐ quitoes abundance were observed between the kebeles (P = 0.001). Anopheles arabiensis was susceptible to propoxur, but resistant to pyrethroids. However, An. pharoensis was susceptible to all pyrethroids and carbamates tested. Conclusions: This study showed a high variation in malaria incidence and Anopheles between kebeles. The observed susceptibility of the malaria vectors to propoxur warrants using this insecticide for indoor residual spraying, and the results from this study will be used as a baseline for the trial.
Management of chronic pain in older adults

#### The bottom line Chronic pain is one of the most common conditions encountered by healthcare professionals, particularly among older (≥65 years) patients.1 Pain is associated with substantial disability from reduced mobility, avoidance of activity, falls, depression and anxiety, sleep impairment, and isolation.1 2 3 Its negative effects extend beyond the patient, to disrupt both family and social relationships. Chronic pain poses a significant economic burden on society.1 Prevalence rates for pain are expected to increase as populations continue to age—by 2035 an estimated one quarter of the population in the European Union will be 65 or older—thereby increasing the public health impact of pain. Healthcare providers, irrespective of specialty, should develop competencies to assess and manage chronic pain in their older patients. In this review we summarize recent evidence on the assessment and management of pain in older patients. Evidence is taken from systematic reviews, meta-analyses, individual trials, and clinical guidelines. #### Sources and selection criteria We searched Medline, Embase, and the Cochrane Database of Systematic Reviews using the search terms “chronic pain”, “older adults”, “prevalence”, “diagnosis”, and “treatment”. We specifically focused on identifying and reviewing systematic reviews, meta-analyses, high quality randomized controlled trials, …
Perception, motivators and obstacles of biosecurity in cattle production

Farm biosecurity includes the prevention of disease transmission within and between farms. Two studies were set up to investigate what motivates and withholds farmers to implement biosecurity measures. The first study aimed to assess the perception of cattle farmers towards biosecurity and to identify possible reasons for its low application. This study consisted of a focus group discussion, of which the trends were used to develop a questionnaire for Flemish cattle farmers. Although the 91 participating farmers were familiar with several measures, they associated them with disease prevention rather than biosecurity. Nearly all farmers (98%) identified their herd veterinarian as their main source of information. Twenty percent and 32% of the respondents were convinced that the implementation of biosecurity would cost them more money and time, respectively. Finally, 80% of the farmers saw room for improvement of their herd, but indicated a need for practical information. The second study aimed to identify the key elements of twenty preselected biosecurity measures, motivators and obstacles for their implementation. They were judged by twenty-two cattle stakeholders, such as farmers, veterinarians and advisors, on feasibility, efficacy and return on investment. A box for parturition, a plan for rodent control and cleaning and disinfection of the stables scored highest overall. The lowest scoring measures were showering before entering the stables and an animal-free period of 24 hours. Their return on investment scored very low, since high investments are required. For a farmer to understand why biosecurity is beneficial, he must understand all risks and costs of disease and how biosecurity may reduce these risks and costs.
Optimizing Mental Health Treatment for Emerging Adults with First-Episode Psychosis

ABSTRACT Growing data have highlighted that the first few years of psychotic disorders may be a ‘critical period’ during which the receipt of evidence-based treatment may foster disproportionately positive effects on the course of these devastating illnesses. In response to this research, there is a growing international effort to expand access to specialized, comprehensive mental health care to youth and young adults with first-episode psychosis. Yet, despite these advances in care, outcomes among individuals participating in specialized services for first-episode psychosis remain suboptimal. One strategy that may aid in improving outcomes among individuals with first-episode psychosis is greater consideration of the normative developmental processes unfolding during the age when psychotic disorders typically emerge—a developmental stage betwixt and between adolescence and adulthood known as emerging adulthood. Thus, the goal of this paper is to highlight strategies through which mental health treatment may be optimized for individuals with first-episode psychosis by aligning these treatments with the normative developmental processes unfolding during emerging adulthood.
THE PROVISON OF ORIENTATION TO THE ANXIETY LEVELS OF THE NEW PATIENT AT THE PONEK (OBGYN) GENERAL HOSPITAL JOMBANG

Introduction. Patients who first entered hospital usually has the anxiety because of hospital environment is different with their previous environment. The aim of this study was to analyze the effectof orientation to the level of anxiety in new patient in PONEK ward general hospital Jombang.Method. The type of this research was quasy experimental study with before and after with control design. The number of sample for the experimental group was 30 people control group was 30 subjects with quota sampling method. The independent variable in this study was the orientation and the dependent variable was patient’s anxiety. Research instrument used booklet. The data were processed and analyzed with the Wilcoxon sign rank test and mann whitney test, the alternative hypothesis was accepted if p<0,05.Result. Based on the analysis was of mann whitney test p- value of 0,000 is < α 0,05 this was conclude that there was an effect of new orientation to the level anxiety level of the new patients at the ponek ward general hospital jombang. Discussion. Health workers actively participate in providing orientation the new patients, therefore it can reduce the anxiety that occur when is admitted hospital and should be used as amandatory orientation program the new patient admission. Key word: providing orientation, level of anxiety, new patient.
Analiza građe autolognoga hrskavičnoga presatka uzgojenoga u bioreaktoru za liječenje koštano-hrskavičnih oštećenja na modelu ovce [Structural analysis of bioreactor - engineered autologous cartilage graft for treatment of osteochondral defects in sheep model]

Articular cartilage lesions remain a major unsolved clinical problem due to the poor intrinsic repair capacity of the cartilage. While various options are available to repair a damaged joint surface, none can reliably restore the natural articular cartilage integrity resulting in a limited ability of the tissue to withstand mechanical stresses during physical activities. The aim of this study was to engineer cartilage tissue grafts with functional properties resembling those of native cartilage and use them for the autologous treatment of chronic osteochondral defects in sheep stifle joint. Nasal septum chondrocytes were seeded on bilayerd scaffold and cultured in perfusion bioreactor. Sixteen sheep were randomly assigned to four study groups: nasal constructs (NC), articular constructs (AC), cell free scaffolds (CFS), and negative control (CTR). First surgery was to create 4 mm chondral defects on both right femoral condyles. Biopsy of nasal septum cartilage was also performed. After six weeks of culturing and defect chronification, tissue grafts were implanted in osteochondral defects 6,5 mm in diameter and 5 mm deep. Animals were sacrificed 3 and 12 months afterwards. Detailed gross, histology and immunohistochemistry analyses were performed. Results demonstrate feasibility of bioreactor tissue production. Nasal septum cartilage chondrocytes have the capacity to restore articular cartilage in vivo.
Incorporating temperament traits in dairy cattle breeding programs: challenges and opportunities in the phenomics era

April 2020, Vol. 10, No. 2 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com © Chang, Brito, Alvarenga, and Wang Feature Article Incorporating temperament traits in dairy cattle breeding programs: challenges and opportunities in the phenomics era