Miracle-dz/UniFAR-FTUs huggingface dataset:
Stenting for middle aortic syndrome

Editor,—Most of the patients in the article “Stenting for middle aortic syndrome” by Rajszys et al had long lesions with significant peak systolic gradients across the stenotic segment. Primary stenting of the lesions significantly reduced the peak systolic gradients.1 We fail to understand the authors’ preference for anticoagulants over ticlopidine. Studies have consistently shown that use of antithrombotic drugs are far superior to anticoagulants, not only in lowering the incidence of stent thrombosis but also in preventing bleeding complications.2 The use of anticoagulants has largely been abandoned worldwide, even …
Chemical composition and sensory quality of bovine milk as affected by type of forage and proportion of concentrate in the feed ration.

BACKGROUND The objective of this study was to investigate how some small changes in the forage content of maize and lucerne silage and in the ration between forage and concentrate in the diet of dairy cows affect milk quality. Milk quality was assessed by quantitative descriptive sensory analysis and by analysis of tocopherols and carotenoids as well as fatty acid composition. RESULTS Changing the ratio between maize silage and lucerne silage from 5:1 to 2:1 increased milk fat content of carotenoids (23-27%) and C18:3 n3 (15%), and reduced stale aroma and creamy flavour. Increasing the proportion of concentrates in the feed ration from 0.2 to 0.4 increased energy corrected milk yield (26%), reduced fat content (-10%), increased C18 fatty acids (8-62%) and reduced C16 (-20%) content in milk fat. In addition, this milk type was described by the sensory panel as less oily, less saturated and less yellow. The changes in milk composition were related to differences in feed composition. CONCLUSION The study revealed the potential to produce milk with a distinct composition and sensory quality based on even small changes in the feed composition that are straightforward to implement by farmers.
Substance P Signaling Controls Mast Cell Activation, Degranulation, and Nociceptive Sensitization in a Rat Fracture Model of Complex Regional Pain Syndrome

Background: Patients with complex regional pain syndrome have increased tryptase in the skin of the affected extremity indicating mast cell (MC) accumulation and degranulation, processes known to be mediated by substance P (SP). The dysregulation of SP release from primary afferent neurons is characteristic of complex regional pain syndrome. The authors hypothesized that SP acting through the neurokinin-1 receptor results in mast cell accumulation, degranulation, and nociceptive sensitization in a rat model of complex regional pain syndrome. Methods: Groups of 6–10 rats underwent tibia fracture and hind limb casting for 4 weeks, and the hind paw skin was harvested for histologic and immunohistochemical analysis. The effects of a selective neurokinin-1 receptor antagonist (LY303870) and of direct SP intraplantar injection were measured. Dermal MC degranulation induced by sciatic nerve stimulation and the effects of LY303870 on this process were investigated. Finally, the antinociceptive effects of acute and chronic treatment with a MC degranulator (48/80) were tested. Results: The authors observed that fracture caused MC accumulation, activation, and degranulation, which were inhibited by LY303870; the percentage of MCs in close proximity to peptidergic nerve fibers increased after fracture; electrical stimulation caused MC activation and degranulation, which was blocked by LY303870; intraplantar SP-induced MC degranulation and acute administration of 48/80 caused MC degranulation and enhanced postfracture nociception, but MC-depleted animals showed less sensitization. Conclusions: These results indicate that facilitated peptidergic neuron-MC signaling after fracture can cause MC accumulation, activation, and degranulation in the injured limb, resulting in nociceptive sensitization.
A Simulation Model of the Effect of Fertility Reduction on Economic Growth in Africa

We investigate the effects of a decline in fertility on economic growth and development outcomes using a macrosimulation model. We incorporate three fertility effects that have previously not been included in such models: the effect of fertility on child health and later worker productivity; the effect of fertility on savings; and a feedback mechanism from female education to fertility, in which changes in female education that are induced by declining fertility in turn alter subsequent fertility. We also improve the model of the economy by incorporating a more realistic three-sector framework and by allowing for labor market imperfections. Using data from Nigeria, we find that adding these channels roughly doubles the effect of an initial fertility decline on income per capita after 50 years when compared to previous simulation results.
O‐2A progenitors of the mouse optic nerve exhibit a developmental pattern of antigen expression different from the rat

In a previous study we demonstrated that differentiation and development of mouse oligodendrocytes is similar to that of the rat after the stage at which O4 is acquired. In this present study we compare directly the early differentiation of oligodendrocytes in the mouse and rat post natal optic nerve and show that the two species differ at the O‐2A progenitor and proligodendroblast stages. Mouse progenitors show a variety of morphologies compared to the typical bipolar appearance in the rat. Many murine cells fail to immunolabel with A2B5, GD3, O4, and RmAb, classical markers for rat progenitors, proligodendroblasts, and immature oligodendrocytes. We find that these “unlabeled” cells stain for GAP‐43 and that expression of GAP‐43 overlaps A2B5 and GD3 in the earlier progenitors and 04, RmAb, and 01 in the later proligodendroblasts and immature oligodendrocytes.
Feature Learning for Accurate Time Prediction in Congested Healthcare Systems

Time prediction in healthcare systems such as outpatient clinics, hospital wards, and emergency departments is an essential component of decision making. Predictions are used for effective and efficient resource allocation, optimised ambulance routing, and accurate delay announcement. In this work, we focus on time prediction in congested healthcare systems, where patients share scarce resources such as nurses, physicians, and MRI machines. To achieve accurate time prediction in this setting, features describing the clinical state of the patient (e.g., severity of condition, age, and medical history) need to be combined with features that capture cross-patient information. To include the interplay of patients in time prediction, we present a method to learn congestion-related features, such as the current number of patients in the hospital and recent lengths-of-stay. To this end, we propose the model of congestion graphs, which are grounded in queueing theory and are mined from event logs as they are readily available in today’s healthcare information systems. We evaluated the proposed method on two real-world healthcare systems, namely an Israeli emergency department and an outpatient cancer hospital in the United States. Our experimental results show that using congestion feature learning we get up to 40% improvement when predicting the remaining time in the system, and 20% improvement when predicting the time to meet with the first provider.
Heterogeneity of collagens in rabbit cornea: type III collagen.

Whole neonate rabbit corneas and adult corneas containing 2-week-old scars were incubated in the presence of [14C] glycine. Radiolabeled collagen extracted from the corneas and scar tissue were analyzed by sodium dodecylsulfate/polyacrylamide gel electrophoresis and fluorography to determine the types and relative quantity of collagen polypeptides present and synthesized by these tissues. In addition to other collagen types, type III was found in both neonate cornea and scar tissue from adult cornea, albeit in relatively small quantities. Type III collagen in normal cornea was associated with the residue after pepsin digestion and formic acid extraction of the tissue, and the same type of collagen was extracted from scar tissue after similar treatment. Type III collagen-specific monoclonal antibody bound to developing normal corneas and healing adult tissue sections, as determined by immunofluorescence. Antibody binding was localized to the endothelium and growing Descemet's membrane in fetal and neonate corneas, and restricted to the most posterior region of the corneal scar tissue. Although monoclonal antibody to keratan sulfate, used as a marker for stromal fibroblasts, bound to most of the scar tissue, the antibody failed to bind to the posterior scar tissue positive for type III collagen. We conclude that endothelial cells from fetal and neonate rabbit cornea and endothelium-derived fibroblasts from healing wounds of adult cornea synthesize and deposit type III collagen. Moreover, this collagen appears to be incorporated into the growing Descemet's membrane of normal corneas and narrow posterior portion of the scar tissue. (ABSTRACT TRUNCATED AT 250 WORDS)
Wet season range fidelity in a tropical migratory ungulate.

1. In migratory populations, the degree of fidelity and dispersal among seasonal ranges is an important population process with consequences for demography, management, sensitivity to habitat change and adaptation to local environmental conditions. 2. Characterizing patterns of range fidelity in ungulates, however, has remained challenging because of the difficulties of following large numbers of marked individuals across multiple migratory cycles and of identifying the appropriate scale of analysis. 3. We examined fidelity to wet season (i.e. breeding) ranges in a recently declining population of wildebeest Connochaetes taurinus Burchell in northern Tanzania across 3 years. We used computer-assisted photographic identification and capture-recapture to characterize return patterns to three wet season ranges that were ecologically discrete and topographically isolated from one another. 4. Among 2557 uniquely identified adult wildebeest, we observed 150 recaptures across consecutive wet seasons. Between the two migratory subpopulations, the probability of remaining faithful to wet season areas ranged between 0·82 and 1·00. Animals from a non-migratory segment of the population (near Lake Manyara National Park) were rarely observed in other wet season ranges, despite proximity to one of the migratory pathways. 5. We found no effect of sex on an individuals' probability of switching wet season ranges. However, the breeding status of females in year i had a strong influence on patterns of range selection in year i + 1, with surviving breeders over three times as likely to switch ranges as non-breeders. 6. Social-group associations between pairs of recaptured animals were random with respect to an individual's wet season range during the previous or forthcoming wet seasons, suggesting that an individual's herd identity during the dry season does not predict wet season range selection. 7. Examining fidelity and dispersal in terrestrial migrations improves our understanding of the constraints that migrants experience when they face rapid habitat changes or fluctuations in environmental conditions.
Effects of Polychlorinated Biphenyl Congener Concentration and Sediment Supplementation on Rates of Methanogenesis and 2,3,6-Trichlorobiphenyl Dechlorination in an Anaerobic Enrichment

We have employed a method of enrichment that allows us to significantly increase the rate of reductive polychlorinated biphenyl (PCB) dechlorination. This method shortens the time required to investigate the effects that culture conditions have on dechlorination and provides an estimate of the potential activity of the PCB-dechlorinating anaerobes. The periodic supplementation of sterile sediment and PCB produced an enhanced, measurable, and sustained rate of dechlorination. We observed volumetric rates of the dechlorination of 2,3,6-trichlorobiphenyl (2,3,6-CB) to 2,6-dichlorobiphenyl (2,6-CB) of more than 300 μmol liter-1 day-1 when the cultures were supplemented daily. A calculation of this activity that is based on an estimate of the number of dechlorinating anaerobes present indicates that 1.13 pmol of 2,3,6-CB was dechlorinated to 2,6-CB day-1 bacterial cell-1. This rate is similar to that of the reductive dechlorination of 3-chlorobenzoate by Desulfomonile tiedjei. Methanogenesis declined from 585.3 to 125.9 μmol of CH4 liter-1 day-1, while dechlorination increased from 8.2 to 346.0 μmol of 2,3,6-CB dechlorinated to 2,6-CB liter-1 day-1.
FcyRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH 2-containing inositol 5-phosphatase ( SHIP ) , dephosphorylation of the linker of activated T-cells ( LAT ) and inhibition of calcium mobilization

T h e low-affinity receptor for immunoglobulin G , FcyRIIB, is expressed on most B-cells and on immature and activated mature T-cells. Coaggregation of FcyRIIB with the B-cell antigen receptor (BCR) leads to attenuation of BCRinduced blastogenesis and cell proliferation via inhibition of p21'*', phosphatidylinositol 3-kinase (PI3-K) and phospholipase Cy (PLCy) activation. These effects are mediated, at least in part, by the recruitment of SH2-containing protein tyrosine phosphatase-1 (SHP-1) and -2 (SHP-2) and SH2-containing inositol 5-phosphatase (SHIP). In this report, we demonstrate that FcyRIIB coaggregation with the T-cell antigen receptor (TCR), which may occur when T-cells recognize antibody-coated target cells, leads to inhibition of TCR-induced phosphorylation of the linker of activated T-cells (LAT). When phosphorylated, LAT functions as an adapter molecule and recruits P13-K. Additionally, we demonstrate that PI3-K is required for TCR-induced Ca2' mobilization. Together, these data suggest that FcyRIIB may inhibit TCR-mediated Cay+ mobilization, in part via inhibition of LAT phosphorylation and subsequent inhibition of PI3-K activation. A similar mechanism has been described in B-cells, where FcyRIIB co-aggregation with the BCR leads to inhibition of PI3-K activity via dephosphorylation of CD19. I t is likely that, in both cell types, levels of PtdIns(3,4,5)P3 are additionally modulated via the enzymic activity of SHIP.
Adaptive synchronization for nonlinear coupled complex network with nonidentical nodes

This paper investigates the synchronization of nonlinear coupled complex networks with non-identical nodes. Using tools from matrix, graph and Lyapunov stability theories, sufficient condition for nonlinear coupled complex networks with nonidentical nodes is obtained under an adaptive control protocol. We also design a distributed adaptive strategy on the strengths, which can guarantee that the synchronization condition doesn't require any global information except a connection assumption. Finally numerical simulations are presented to illustrate the theoretical findings.
Radiation therapy alone or in combination with surgery in the treatment of carcinoma of the esophagus

The role of radiation in the treatment of squamous cell carcinoma of the esophagus was examined in a review of 74 patients treated with curative intent between 1974 and 1981. Aspects studied included the pattern of failure, the use of radiation as a surgical adjuvant, achievement of palliation, and the presence of technical or clinical factors predicting for a better outcome. The group was divided into 9 patients irradiated after esophageal resection, 14 patients irradiated before resection, and 51 patients treated with radiation and no resection. Median and 2‐year survival rates among 51 patients treated by radiation without esophagectomy were 8.8 months and 11%, whereas they were 9.7 months and 0% in patients treated by radiation followed by resection, and 9.5 months and 28% in patients undergoing resection followed by radiation. Local failures were suffered in 28/51 patients treated without esophagectomy with rates of 2/4, 7/10, 7/15, and 5/10 after 50–55 Gy, 55–60 Gy, 60–65 Gy, and 65–69 Gy, respectively. Although prognosis for patients presenting with unresectable disease remains poor, a somewhat better outcome may be expected in patients treated with postoperative radiation after potentially unfavorable resections. Other predictors include sex and disease stage.
Citation analysis as a literature search method for systematic reviews

Systematic reviews are essential for evaluating biomedical treatment options, but the growing size and complexity of the available biomedical literature combined with the rigor of the systematic review method mean that systematic reviews are extremely difficult and labor‐intensive to perform. In this article, I propose a method of searching the literature by systematically mining the various types of citation relationships between articles. I then test the method by comparing its precision and recall to that of 14 published systematic reviews. The method successfully retrieved 74% of the studies included in these reviews and 90% of the studies it could reasonably be expected to retrieve. The method also retrieved fewer than half of the total number of publications retrieved by these reviews and can be performed in substantially less time. This suggests that the proposed method offers a promising complement to traditional text‐based methods of literature identification and retrieval for systematic reviews.
Associations between access to farmers’ markets and supermarkets, shopping patterns, fruit and vegetable consumption and health indicators among women of reproductive age in eastern North Carolina, USA

Abstract Objective We examined associations between access to food venues (farmers’ markets and supermarkets), shopping patterns, fruit and vegetable consumption and health indicators among women of reproductive age in eastern North Carolina, USA. Design Access to food venues was measured using a Geographic Information System incorporating distance, seasonality and business hours, to quantify access to farmers’ markets. Produce consumption was assessed by self-report of eating five or more fruits and vegetables daily. BMI and blood pressure were assessed by clinical measurements. Poisson regression with robust variance was used for dichotomous outcomes and multiple linear regression was used for continuous outcomes. As the study occurred in a university town and university students are likely to have different shopping patterns from non-students, we stratified analyses by student status. Setting Eastern North Carolina. Subjects Low-income women of reproductive age (18–44 years) with valid address information accessing family planning services at a local health department (n 400). Results Over a quarter reported ever shopping at farmers’ markets (114/400). A larger percentage of women who shopped at farmers’ markets consumed five or more fruits and vegetables daily (42·1 %) than those who did not (24·0 %; P < 0·001). The mean objectively measured distance to the farmers’ markets where women reported shopping was 11·4 (sd 9·0) km (7·1 (sd 5·6) miles), while the mean distance to the farmers’ market closest to the residence was 4·0 (sd 3·7) km (2·5 (sd 2·3) miles). Conclusions Among non-students, those who shopped at farmers’ markets were more likely to consume five or more servings of fruits and vegetables daily. Future research should further explore potential health benefits of farmers’ markets.
Durable complete remission of poor performance status metastatic lung adenocarcinoma patient treated with second-line erlotinib: a case report

This paper presents a rare case of an elderly patient treated with erlotinib for disseminated lung adenocarcinoma with poor performance status (Eastern Cooperative Oncology Group performance status [PS]3). This treatment led to a long duration of complete remission according to Response Evaluation Criteria in Solid Tumors 1.1 – almost 7 years (81 months) of progression-free survival (PFS) and overall survival (OS) of 10 years by March 2017. The treatment with erlotinib started in September 2008 and it was well tolerated with no adverse effects. Mutation analyses (real-time polymerase chain reaction method) revealed deletion of EGFR (epidermal growth factor receptor) gene and wild-type Kirsten-ras protein gene in exon 19. In May 2015, the patient relapsed with jaundice and enlarged lymph nodes of the liver hilum, with no other metastasis, PS 2. Biopsy confirmed metastasis of lung adenocarcinoma. EGFR molecular testing did not reveal T790M mutation. Treatment was continued with gemcitabine–cisplatin chemotherapy. A total of six cycles were administered with nearly complete response and Eastern Cooperative Oncology Group performance status 0. Further on, gemcitabine monotherapy has been administered with nearly complete response maintained and OS of 10 years by March 2017. This report describes an extremely rare case of a poor performance patient with advanced metastatic adenocarcinoma harboring EGFR mutation – deletion in exon 19 – who was receiving salvage erlotinib and had a complete response with 81 months of PFS followed by a relapse and subsequent chemotherapy which led to nearly complete response, with an OS of 10 years by March 2017. Such a complete response to tyrosine kinase inhibitor therapy in a poor PS patient, with long PFS and OS achieved, justifies tyrosine kinase inhibitor treatment approach in poor PS patients with EGFR-sensitizing tumors, and furthermore points to the feasibility of administering chemotherapy at the time of relapse.
A 1.1V 35μm × 35μm thermal sensor with supply voltage sensitivity of 2°C/10%-supply for thermal management on the SX-9 supercomputer

Presented here is a thermal sensor, based on transistor off-leakage current, that allows measurement error of less than 3.1degC at 90degC and less than 2degC at 10% Vdd deviation. For experimental evaluation, 11 thermal sensors, each of which occupied only 35 mum times 35 mum area, were placed on a chip, and both the location of a hotspot and the overall temperature distribution were successfully measured and agreed with simulation.
Energy management system as a mean for the integration of distributed energy sources with low voltage network

The paper concerns energy management in low voltage grid-connected microgrid integrating renewable and controllable energy sources, loads and storage systems. The central control system is presented which optimize the microgrid operation by minimizing the costs of energy in the time horizon. The system determines set-points for controllable sources and storage units. In formulating the objective function constraints regarding the network capacity are taken into account, i.e. voltage limits in the network nodes and load carrying capacity limits of lines and the supplying transformer. The management system enables the integration of energy sources into existing networks without re-designing the network itself and microgrid operation at minimum costs.