Miracle-dz/UniFAR-FTUs huggingface dataset:
Creatinine-Based Glomerular Filtration Rates and Microalbuminuria for Detecting Metabolic Abnormalities in US Adults: The National Health and Nutrition Examination Survey 2003–2004

Background/Aims: Guidelines suggest searching for metabolic complications of chronic kidney disease when glomerular filtration rates (GFR) or urinary albumin tests are abnormal. This study aimed to quantify diagnostic test characteristics of these measures for detecting metabolic abnormalities. Methods: Subjects were participants aged ≧20 years (n = 7,778) in the US National Health and Nutrition Examination Survey 2003–2004. Low GFR was defined as creatinine-based estimate <60 ml/min per 1.73 m2; abnormal urinary albumin-creatinine ratio as ≧20 mg/dl in men, ≧30 mg/dl in women; and metabolic abnormalities as abnormal potassium, hemoglobin, bicarbonate, phosphorus, or parathyroid hormone levels. Results: Of adults, 5.66% had low GFR and 8.14% abnormal urinary albumin-creatinine ratio. Overall, 15.09% had ≧ one metabolic abnormality, as did 34.07% with low GFR (p < 0.0001) and 24.27% with abnormal urinary albumin-creatinine ratio (p = 0.0021). Considered as a diagnostic test, the sensitivity, specificity, and positive and negative predictive values of low GFR for detecting ≧1 metabolic abnormality were 0.13, 0.96, 0.34, and 0.86, respectively. Corresponding values for abnormal urinary albumin-creatinine ratio were 0.13, 0.92, 0.24, and 0.86. Conclusions: A policy of searching for metabolic complications in every adult with low GFR or microalbuminuria has limited diagnostic yield.
Mathematical Biology Reaction networks and evolutionary game theory

The powerful mathematical tools developed for the study of large scale reaction networks have given rise to applications of this framework beyond the scope of biochemistry. Recently, reaction networks have been suggested as an alternative way to model social phenomena. In this “socio-chemical metaphor” molecular species play the role of agents’ decisions and their outcomes, and chemical reactions play the role of interactions among these decisions. From here, it is possible to study the dynamical properties of social systems using standard tools of biochemical modelling. Electronic supplementary material The online version of this article (doi:10.1007/s00285-012-0626-6) contains supplementary material, which is available to authorized users. T. Veloz (B) Mathematics Department, University of British Columbia, Kelowna, BC V1V 1V7, Canada e-mail: tomas.veloz@ubc.ca T. Veloz · P. Razeto-Barry Instituto de Filosofía y Ciencias de la Complejidad IFICC, Los Alerces 3024, Ñuñoa, Santiago, Chile e-mail: prazeto@ificc.cl P. Razeto-Barry Universidad Diego Portales, Vicerrectoría Académica, Manuel Rodríguez Sur 415, Santiago, Chile P. Dittrich Friedrich-Schiller-University Jena, Institute of Computer Science Bio Systems Analysis Group, 07743 Jena, Germany e-mail: peter.dittrich@uni-jena.de A. Fajardo Departamento de Biología, Universidad de los Andes, Cra 1 N 18A-12, Bogotá, Colombia e-mail: alfajardoa@gmail.com
Incremental Costs for Psoriasis and Psoriatic Arthritis in a Population-based Cohort in Southern Sweden: Is It All Psoriasis-attributable Morbidity?

Objective. To estimate incremental costs for patients with psoriasis/psoriatic arthritis (PsO/PsA) compared to population-based referents free from PsO/PsA and estimate costs attributable specifically to PsO/PsA. Methods. Patients were identified by International Classification of Diseases, 10th ed., codes for PsO/PsA using information from 1998 to 2007 in the Skåne Healthcare Register, covering healthcare use for the population of the Skåne region of Sweden. For each patient, 3 population-based referents were selected. Data were retrieved from Swedish registers on healthcare, drugs, and productivity loss. The human capital method was used to value productivity losses. Mean annual costs for 2008 to 2011 were assessed from a societal perspective. Results. We identified 15,283 patients fulfilling the inclusion criteria for PsO [n = 12,562, 50% women, mean age (SD) 52 (21) yrs] or PsA [n = 2721, 56% women, mean age 54 (16) yrs] and included 45,849 referents. Mean annual cost per patient with PsO/PsA was 55% higher compared to referents: €10,500 vs €6700. The cost was 97% higher for PsA compared to PsO. Costs due to productivity losses represented the largest share of total costs, ranging from 52% for PsO to 60% for PsA. Biological drug costs represented 10% of the costs for PsA and 1.6% for PsO. The proportion of cost identified as attributable to PsO/PsA problems was greatest among the patients with PsA (drug costs 71% and healthcare costs 31%). Conclusion. Annual mean incremental societal cost per patient was highest for PsA, mainly because of productivity losses and biological treatment. A minor fraction of the costs were identified as attributable to PsO/PsA specifically, indicating an increased morbidity in these patients that needs to be further investigated.
Cardiovascular Disease and Risk Management : Standards of Medical Care in Diabetes d 2019

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations, please refer to the Standards of Care Introduction. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes. org/SOC.
General Principles of Geriatric Drug Therapy

Ms. Gutierrez is a 74-year-old female with a history of atrial fibrillation, type 2 diabetes, and hypertension. She recently visited her primary care provider (PCP) due to trouble sleeping at night. Her PCP prescribed zolpidem 5 mg at bedtime as needed for sleep without inquiring about patient preference for treatment. Despite taking zolpidem nightly for several weeks, Ms. Gutierrez continued to have trouble sleeping, so she purchased an over the counter medication to help. While her sleep improved, she noticed she had some nighttime incontinence and fell twice in the last week getting out of bed. She returned to her PCP who prescribed her tolterodine for incontinence symptoms and told her to rise slowly from her bed each morning.
High-Speed Microscopy Scanning of Microtiter Plates at Unprecedented Speed

In nearly all cell culture applications it is critical to control cell growth and cell status regularly. Due to the tiny dimensions of cells the morphologic assessment has to be assisted by microscopy. A very common and widespread technique for making ceils that are almost transparent visible is phase cantrast microscopy. Ceils are usually cultured in nutrient medium on transparent plastic material for example microtiter plates (MTPs). Such a plate which has a footprint of about 128 mm x 85 mm contains several weils which are separate compartments for the ceils to grow in. Microscopic analysis directly takes place in these microtiter plates on inverted microscopes. In order to get a good overview of the ceil culture status it is helpful to image the whole content of an entire weil of a microtiter plate. This is especiaily true because cell colanies tend to grow preferably in the border regions of a weil. Usually it is not just one single weil on a MTP that needs to be imaged but the whole plate. As the weils are closely adjacent to each other the weil bottarn area covers almost the whole plate's footprint. As a consequence, to examine a completely filled microtiter plate under a microscope means imaging
Cardiac Imaging Impaired Systolic Function by Strain Imaging in Heart Failure With Preserved Ejection Fraction

*Cardiovascular Division ts; yMedical University ffairs, Medical Center South Carolina; xUnivers harmaceuticals, East Han llas, Texas; and the #Univ on, Shah, Zile, Pieske, port from and/or have con of the PARAMOUNT s an employee of Novartis relevant to the contents ntributed equally to this pt received July 29, 2013; tember 10, 2013. his study sought to determine the frequency and magnitude of impaired systolic deformation in heart failure with preserved ejection fraction (HFpEF).
A Scheme to Design Community Detection Algorithms in Various Networks

Network structures, consisting of nodes and edges, have applications in almost all subjects. A set of nodes is called a community if the nodes have strong interrelations. Industries (including cell phone carriers and online social media companies) need community structures to allocate network resources and provide proper and accurate services. However, most detection algorithms are derived independently, which is arduous and even unnecessary. Although recent research shows that a general detection method that serves all purposes does not exist, we believe that there is some general procedure of deriving detection algorithms. In this paper, we represent such a general scheme. We mainly focus on two types of networks: transmission networks and similarity networks. We reduce them to a unified graph model, based on which we propose a method to define and detect community structures. Finally, we also give a demonstration to show how our design scheme works.
Cochlear Implant and Vestibular Function

Objectives: To document incidences of vestibular dysfunction after cochlear implantation and investigate why it occurs. This work was also motivated by a desire to provide the basis for better preoperative counseling and postoperative vestibular therapy to cochlear implant patients. Setting: Melbourne Cochlear Implant Clinic at a tertiary referral hospital. Study Design: Prospective observational study. Patients: One hundred forty-six adult implant recipients, mean age, 60 years (range, 20-90 yr). Main Outcome Measures: Postoperative vestibular disturbance was defined as symptoms lasting for 1 week or longer after surgery. The differences in preoperative and postoperative vestibular function were measured from subjective assessments (Dizziness Handicap Inventory and Activity Balance Confidence questionnaires) and objective assessments (bithermal caloric tests). The position of the postoperative electrode was classified as "loose", "regular", or "tight" fitting. Results: Thirty-two percent of patients reported vestibular disturbance and had poorer Dizziness Handicap Inventory, Activity Balance Confidence, and caloric results in the implanted ear after surgery. Patient age, cause, and preoperative caloric result did not predict postoperative vestibular symptoms. Recipients aged 70 years or older had significantly poorer caloric results on the implanted side after surgery that was not related to the intracochlear electrode position or surgical team. Conclusion: One-third of recipients can expect to experience a significant vestibular disturbance after surgery, regardless of age, cause, or preoperative caloric result. "Older" ears seem more prone to permanent injury after cochlear implantation.
FL-Trickle: New Enhancement of Trickle Algorithm for Low Power and Lossy Networks

The Trickle algorithm is one of the main components of the IPv6 Routing Protocol for Low Power and Lossy Networks (RPL). Trickle is used to maintain and to control messages in the network. However, this algorithm has some limitations in terms of power consumption, overhead, and convergence time. In this paper, we present a new improvement of the Standard Trickle algorithm, named Flexible Trickle Algorithm (FL-Trickle). Based on the T time parameters and the Minimum Interval values, the new trickle allows reducing the delay needed to transmit control messages as well as the transmission rate. A comparison has been made between the FL-Trickle, the standard Trickle and the Trickle-Plus algorithms. Simulation results show that our proposed approach outperforms both the standard trickle and the Trickle-Plus in terms of convergence time, overhead and energy consumption. FL-Trickle increases the convergence time by up 58%, reduces the overhead by up to 69% and the energy consumption by up to 62%.
Transcription Factor ZBP-89 Cooperates with Histone Acetyltransferase p300 during Butyrate Activation of p21 waf1 Transcription in Human Cells*

Inducible p53-independent regulation of the cyclin-dependent kinase inhibitor p21 waf1 transcription is mediated through proximal GC-rich sites. Prior studies have shown that Sp1, Sp3, and the histone acetylase co-activator p300 are components of the complexes binding to these sites. Although Sp1 and Sp3 collaborate with p300, a direct interaction between Sp1 and p300 does not occur. This study sought to determine whether ZBP-89 rather than Sp1 is the direct target of p300 during butyrate induction of p21 waf1 . ZBP-89 (BFCOL1, BERF-1, ZNF 148) is a Krüppel-type zinc finger transcription factor that binds to GC-rich elements and represses or activates known target genes. Adenoviral-mediated expression of ZBP-89 in HT-29 cells revealed that ZBP-89 potentiates butyrate induction of endogenous p21 waf1 gene expression. Further, cotransfection of a ZBP-89 expression vector with a 2.3-kilobase p21 waf1 reporter recapitulated the potentiation by butyrate. DNase I footprinting analysis of the human p21 waf1 promoter with recombinant ZBP-89 identified a binding site at −245 to −215. Electrophoretic mobility shift assays confirmed that both recombinant and endogenous ZBP-89 and Sp1 bind to this element. The potentiation was abolished in the presence of adenoviral protein E1A. Deletion of the N-terminal domain of ZBP-89 abolished the potentiation mediated by butyrate treatment. This same deletion mutant abolished the ZBP-89 interaction with p300. Cotransfection of p300 with ZBP-89 stimulated the p21 waf1 promoter in the absence of butyrate. p300 co-precipitated with ZBP-89 but not with Sp1, whereas ZBP-89 co-precipitated with Sp1. Together, these findings demonstrate that ZBP-89 also plays a critical role in butyrate activation of the p21 waf1 promoter and reveals preferential cooperation of this four-zinc finger transcription factor with p300.
A Contrastive Study of English and Chinese Existential Sentences from the Perspective of Cognitive Linguistics

Existentials, which play an irreplaceable role in daily communication sentences, are a kind of special syntactic structure in both English and Chinese. Taking a cognitive perspective, this paper conducts a contrastive analysis of the existential sentences in terms of visual perception, mental perception and information encoding, in the hope of finding out the similarities and differences between them. Copyright © (2018) Francis Academic Press, UK DOI: 10.25236/erems.2018. 079 355 2018 International Conference on Educational Research, Economics, Management and Social Sciences (EREMS 2018)
Fungicidal against Aspergillus flavus and Decontaminate AflatoxinB 1 with Neutralized and Acidic electrolyzed oxidizing water

One of serious food safety problems is likely to be Food-borne mycotoxins. Some mycotoxins such as aflatoxins (especially aflatoxinsB1) mainly produced by A.flavus, are considered to be serious contaminant of food. This study investigated the effectiveness of Neutralized electrolyzed oxidizing water (NEW) and Acidic electrolyzed oxidizing water (AcEW) on Fungicidal against Aspergillus flavus and decontaminate AflatoxinB1 (AFB1). Both NEW and AcEW possessed potent to inhibit A.flavus. They also have the potent to decontaminate the AFB1 produced by A.flavus. The main conversion production produced by AFB1 treatment with AcEW and NEW were isolated and identified. It is showed that AFB1 (C17H12O6) produce the 8-Cl-9-OH-AFB1 (C17H13O7Cl) treatment with AcEW and NEW. The conversion produce of 8-Cl-9-OH-AFB1 belongs to amphiphilic molecules, which different from the fat solution of AFB1. Furthermore, the mutagenicity assay showed that the conversion produce did not exhibit mutagenic activity.
Comb Studio ’ s Autonomous Aircraft for the IARC 2012

This paper describes the details of an autonomous aircraft capable of exploring cluttered indoor areas without relying on external navigational aids. A Simultaneous Localization and Mapping (SLAM) algorithm is used to fuse information from a laser range sensor, an inertial measurement unit to provide relative position, velocity, and attitude information. Via front-facing camera, the targets including LED light, laser trip wire label and doorplate can be identified. Thus, the aircraft could enter a specified room, find the flash disk, and put down the fake one. The vehicle is intended to be Beihang University Comb Studio’s entry for the International Aerial Robotics Competition in 2012.
Reducing Excessive Medication Administration in Hospitalized Adults With Renal Dysfunction

Medication errors are common and harm hospitalized patients. The authors designed and implemented an automated system to complement an existing computerized order entry system by detecting the administration of excessive doses of medication to adult in-patients with renal insufficiency. Its impact, in combination with feedback to prescribers, was evaluated in 3 participating nursing units and compared with the remainder of a tertiary care academic medical center. The baseline rate of excessive dosing was 23.2% of administered medications requiring adjustment for renal insufficiency given to patients with renal impairment on the participating units and 23.6% in the rest of the hospital. The rate fell to 17.3% with nurse feedback and 16.8% with pharmacist feedback in the participating units ( P < .05 for each, relative to baseline). The rates of excessive dosing for the same time periods were 26.1% and 24.8% in the rest of the hospital. Automated detection and routine feedback can reduce the rate of excessive administration of medication in hospitalized adults with renal insufficiency.
Recruitment of the Actin-binding Protein HIP-55 to the Immunological Synapse Regulates T Cell Receptor Signaling and Endocytosis*

Actin cytoskeleton dynamics critically regulate T cell activation. We found that the cytoplasmic adaptor HIP-55, a Src/Syk-kinases substrate and member of the drebrin/Abp1 family of actin-binding proteins, localized to the T cell-antigen-presenting cell (APC) contact site in an antigen-dependent manner. Using green fluorescent protein fusion proteins, both Src homology 3 (SH3) and actin binding domains were found necessary for recruitment at the T cell-APC interface. HIP-55 was not implicated in conjugate formation and actin polymerization but regulated distal signaling events through binding and activation of hematopoietic progenitor kinase 1 (HPK1), a germinal center kinase (GCK) family kinase involved in negative signaling in T cells. Using RNA interference and overexpression experiments, the HIP-55-HPK1 complex was found to negatively regulate nuclear factor of activated T cell (NFAT) activation by the T cell antigen receptor. Moreover, we show that HIP-55, which partly co-localized with early endocytic compartments, promoted both basal and ligand-dependent T cell receptor (TCR) down-modulation, resulting in a decreased TCR expression. SH3 and actin-depolymerizing factor homology domains were required for this function. As controls, the expression of CD28 and the glycosylphosphatidylinositol-linked protein CD59 was not affected by HIP-55 overexpression. These results suggest that, in addition to binding to HPK1, HIP-55 might negatively regulate TCR signaling through down-regulation of TCR expression. Our findings show that HIP-55 is a key novel component of the immunological synapse that modulates T cell activation by connecting actin cytoskeleton and TCRs to gene activation and endocytic processes.
Mathematics Learning Tools Development Based on Problem Based Learning (PBL) to Increase Students Problem Solving Ability in Senior High School

This research is a development research using Plomp model which consists of three phases that are initial investigation phase, development and assessment. Devices developed RPP and LKPD based Problem Based Learning (PBL) to improve problem solving skills. Learning devices are tested in high school class XI students. Based on the results of the analysis, it can be concluded that the learning device of mathematics are valid, practical and effective. Keywords—Problem Based Learning, Problem Solving Abilities, Plomp Development Model
Web Video Clustering using Playlist

The increase of videos on the Internet has made video clustering more important. Most existing approaches focus on visual or text information to analyze videos. However, existing approaches have problems: text information in metadata tends to be of low quality, and visual or audio information is difficult to analyze. In this paper, we propose a playlist-based video clustering method, a novel framework that can form new clusters independent of text or visual similarities. A playlist is useful because it is based on the viewers’ knowledge or intuitiveness; beyond that, it is not noisy. Our experiments show good result clusters generated by playlist-based clustering and prove that it can capture relativity or proximity among videos.
Effect of heparin on mesangial cell growth and gene expression of matrix proteins.

BACKGROUND Mesangial cell (MC) proliferation and matrix expansion are characteristics of many glomerulopathies. Heparin has been shown to inhibit MC proliferation in vitro and mitigate cell proliferation, matrix expansion, proteinuria, renal insufficiency, and hypertension in experimental glomerulonephritis and subtotal renal ablation. We examined the effect of standard heparin on MC proliferation and matrix protein expression in vitro which necessarily excludes the confounding influences of haemodynamic, inflammatory, haemostatic, and various other processes that are present in vivo. METHODS Gene expression and release of fibronectin (FN), collagen IV and laminin by cultured rat MC were tested in the presence and absence of heparin. In addition the effect of transforming growth factor-beta1 (TGF-beta1) on the gene expression of those matrix proteins was assessed. RESULTS Within a 3-1000 microg/ml concentration range, heparin inhibited gene expression and release of FN by 10% fetal calf serum (FCS)-stimulated MC in a concentration-dependent manner. At concentrations of 300 and 1000 microg/ml, heparin inhibited fibronectin mRNA levels in TGF-beta1 (6 ng/ml) stimulated cells. However, heparin had no effect on gene expression or release of collagen IV or laminin under these conditions. Heparin markedly inhibited 10% FCS-stimulated MC proliferation in a concentration-dependent manner. CONCLUSIONS Heparin inhibited MC growth and fibronectin production. These effects may, in part, account for the reported beneficial effects of heparin on the course of renal disease in experimental animals.