Miracle-dz/UniFAR-FTUs huggingface dataset:
RMSC: Robust modeling of subspace clustering for high dimensional data

Subspace clustering is one of the active research problem associated with high-dimensional data. Here some of the standard techniques are reviewed to investigate existing methodologies. Although, there have been various forms of research techniques evolved recently, they do not completely mitigate the problems pertaining to noise sustainability and optimization of clustering accuracy. Hence, a novel technique called as Robust Modeling of Subspace Clustering (RMSC) presented to solve the above problem. An analytical research methodology is used to formulate two algorithms for computing outliers and for extracting elite subspace from the high-dimensional data inflicted by different forms of noise. RMSC was found to offer higher accuracy and lower error rate both in presence of noise and absence of noise over high-dimensional data.
Zebrafish in Translational Cancer Research: Insight into Leukemia, Melanoma, Glioma and Endocrine Tumor Biology

Over the past 15 years, zebrafish have emerged as a powerful tool for studying human cancers. Transgenic techniques have been employed to model different types of tumors, including leukemia, melanoma, glioblastoma and endocrine tumors. These models present histopathological and molecular conservation with their human cancer counterparts and have been fundamental for understanding mechanisms of tumor initiation and progression. Moreover, xenotransplantation of human cancer cells in embryos or adult zebrafish offers the advantage of studying the behavior of human cancer cells in a live organism. Chemical-genetic screens using zebrafish embryos have uncovered novel druggable pathways and new therapeutic strategies, some of which are now tested in clinical trials. In this review, we will report on recent advances in using zebrafish as a model in cancer studies—with specific focus on four cancer types—where zebrafish has contributed to novel discoveries or approaches to novel therapies.
Mathematics of Control , Signals , and Systems Stochastic Processes for Bounded Noise *

The scalar di¤erential inclusion _ x A f ðxÞ þ gðxÞu; u A 1⁄2 1; 1 ; xð0Þ 1⁄4 x0 ð0:1Þ is considered as a model of the dynamical system _ x 1⁄4 f ðxÞ perturbed by the bounded noise gðxÞu, u A 1⁄2 1; 1 , and the problem of constructing a nontrivial probability measure on the set S of solutions to (0.1) is studied. In particular, it is shown that: (i) every Markov process whose probability measure is supported on S is degenerate, in a sense to be specified (see Theorem 3.1); (ii) given a flow of probability measures mt on the reachable sets Rt of (0.1), satisfying a certain compatibility condition, a Markov process Xt is constructed such that its marginals are exactly mt and (0.1) is satisfied ‘‘from one side’’ (see Theorem 4.1); its finite-dimensional distributions are computed and the regularity of its sample paths is investigated (see Section 5.2); (iii) given a process of a type previously considered, another process Yt is constructed through its finite-dimensional distributions, and its distribution is shown to be supported exactly on S. Finally, a model example is considered (see Section 7).
What is the probability of conception for couples entering an IVF program?

Summary: The outcome of 4225 couples undergoing 8207 in vitro fertilisation (IVF) cycles over a six year period has been analysed using life table analysis. Pregnancy was expressed as a ‘clinical pregnancy ‐fetus visible on ultrasound’ per stimulated cycle oocyte collection, with pregnancies obtained from frozen embryos being referred to the cycle where they were collected. We found that only 1 in 200 patients proceeded beyond six cycles and the cumulative per cent pregnant was 20.7% after the first cycle, with nearly half pregnant within three and over two‐thirds being pregnant within six cycles. We find this is a useful way to present the chance of pregnancy to prospective couples.
Etiología infecciosa en exacerbación de asma

El asma es un problema de salud publica en Mexico; se encuentra entre las 10 primeras causas de atencion en los servicios de salud, especialmente los de urgencias y consulta externa. Las exacerbaciones del asma (crisis de asma o asma aguda) son episodios con un aumento progresivo de la dificultad respiratoria, tos, sibilancias u opresion en el torax, o una combinacion de estos sintomas. Se han identificado infecciones en vias aereas como causa de las exacerbaciones. Se realizo, a los pacientes incluidos en este estudio, analisis microbiologico de la muestra de expectoracion, encontrandose en casi la mitad de las muestras la presencia de microorganismos patogenos asociados a exacerbacion de asma, predominando los de origen bacteriano seguido de los virales. En contraste con lo reportado en la literatura, en nuestro estudio se aislaron con mayor frecuencia bacterias, seguidas de la presencia de virus. Sin embargo, esto no es prueba concluyente de que la infeccion sea la causa de la exacerbacion, ya que no fue posible encontrar una asociacion clara entre la gravedad de la crisis y la presencia de microorganismo patogeno. Abstract
Self-efficacy, Self-esteem, and Subjective Happiness of Teacher Candidates at the Pedagogical Formation Certificate Program

This study investigated the relationship between self-efficacy, self-esteem, and subjective happiness. The study group is composed by 556 (291 female; 265 male) students who were studying at the pedagogical formation program at Mugla Sitki Kocman University. The data were collected by using the General Self-Efficacy Scale-Turkish Form, Self-Confidence Scale, and Subjective Happiness Scale. Pearson product-moment correlation analysis was employed to study the relationship between self-efficacy, self-esteem, and subjective happiness; structural equation modeling was also used for explaining subjective happiness. Initiation, effort, and persistence subdimensions of self-efficacy and internal self-confidence and external self-confidence subdimensions of self-esteem were found to be significantly correlated to subjective happiness. A significant impact of initiation, effort, and persistence subdimensions of self-efficacy and internal self-confidence and external self-confidence subdimensions of self-esteem on subjective happiness was detected. The theoretical implications of the link between self-efficacy, self-esteem, and subjective happiness were discussed.
Sexual dimorphism in the spontaneous recovery from spinal cord injury: a gender gap in beneficial autoimmunity?

Immune cells have been shown to contribute to spontaneous recovery from central nervous system (CNS) injury. Here we show that adult female rats and mice recover significantly better than their male littermates from incomplete spinal cord injury (ISCI). This sexual dimorphism is wiped out and recovery is worse in adult mice deprived of mature T cells. After spinal cord contusion in adult rats, functional recovery (measured by locomotor scores in an open field) was significantly worse in females treated with dihydrotestosterone prior to the injury than in placebo‐treated controls, and significantly better in castrated males than in their noncastrated male littermates. Post‐traumatic administration of the testosterone receptor antagonist flutamide promoted the functional recovery in adult male rats. These results, in line with the known inhibitory effect of testosterone on cell‐mediated immunity, suggest that androgen‐mediated immunosuppression plays a role in ISCI‐related immune dysfunction and can therefore partly explain the worse outcome of ISCI in males than in female. We suggest that females, which are more prone to develop autoimmune response than males, benefit from this response in cases of CNS insults.
Caractérisation multimodale des propriétés de l'os cortical en croissance

L’os est un materiau dont les proprietes evoluent tout au long de la vie en fonction des contraintes environnementales. Aujourd’hui, les modalites d’imagerie permettent aux cliniciens d’evaluer la qualite osseuse chez l’adulte. Malheureusement, ces outils diagnostics ne sont pas adaptes pour l’enfant (nocivite des radiations, anesthesie ou sedation necessaire), et le developpement d’un outil clinique necessite une bonne connaissance des proprietes du tissu osseux pediatrique.Peu d’etudes ont analyse les proprietes du tissu osseux au cours de la croissance. Cette penurie de donnees de reference s’explique par la faible quantite d’echantillons disponible pour les essais en laboratoire et par la qualite meme de ces echantillons pour la plupart «preleves» et associes a une pathologie de l’enfant.Les objectifs de ce travail de these s’inscrivent dans une logique de comprehension des mecanismes et des proprietes de l’os en croissance. L’interet majeur de ce travail est donc d’apporter de nouvelles connaissances sur l’os cortical pediatrique. Les proprietes mecaniques et tissulaires ont ete etudiees via l’utilisation de diverses techniques: la microtomographie, la microradiographie, la FTIRM, la biochimie, la compression, la caracterisation ultrasonore et la nanoindentation. Ce travail a permis de mettre en avant l’evolution de l’os cortical pediatrique vers un etat mature: la structure des fibres de collagene se hierarchise, le tissu se mineralise. Ces changements dans la structure du tissu osseux lui permettent de se rigidifier. Ces travaux de these ont permis de mieux comprendre cette evolution, et vont permettre d’avoir une 1ere base de donnees sur la fibula infantile.
Coordinated control of a grid connected DC micro-grid with multiple renewable sources

This paper presents a coordinated control of a grid connected DC micro-grid between the energy storage system (ESS) DC-DC converter and the VSC. The three different mode of operation is presented i.e (a) Autonomous mode when the DC micro-grid is not connected to grid (b) Current control mode, i.e when either of the ESS or VSC are in current control mode and (C) Dual mode, when both ESS and VSC are in DC link voltage control mode. A MATLAB Simulink model results is given to validate the results in each mode of operation.
Obstetric complications and eating disorders: a replication study.

OBJECTIVE To provide data about the role of obstetric complications (OCs) in a large and well-characterized sample of patients with anorexia nervosa (AN) or bulimia nervosa (BN). METHOD The new sample consists of 150 patients with AN and 35 patients with BN, and 73 healthy women; statistical analyses were performed on the new sample alone and on the larger sample created by merging the new dataset with the previous one (264 AN, 108 BN, and 624 healthy women). All data about OCs were collected blind to diagnostic status. RESULTS OC rates in the replication sample were similar to those of our previous studies. In the whole sample, the risk of developing AN was significantly associated with the occurrence and number of pregnancy, delivery, hypoxic, and dysmaturity complications. The risk of developing BN was significantly associated with dysmaturity complications. Signs of retarded fetal growth (being small and short for gestational age, short head circumference) significantly distinguished BN patients from both AN and healthy individuals. Significantly higher number of OCs were found in the binge eating/purging type of AN, in comparison with restricting AN patients. DISCUSSION Our study provides further evidence of the role of OCs as putative risk factors for the development of eating disorders, showing different pathways between AN and BN.
Is the area measure a historical anomaly?

Green's well-known area theorem establishes an equivalence between the area under the yes-no ROC curve and the percent correct of an unbiased observer in a two-alternative forced-choice (2AFC) task with equivalent stimuli. In this article, we show that this conversion from yes-no detection data to hypothetical performance in a 2AFC task is unnecessary: The same yes-no detection data that are used to compute the area statistic can always be used to compute the percent correct of an unbiased observer in the yes-no detection task itself. We also show that the ROC curve may not be the ideal graphical device for many investigators. A more natural representation of the difficulty of a discrimination task is obtained by plotting the distribution of the posterior betting odds under equal base rates, which can be estimated from their distributions under unequal base rates. Finally, unlike the area measure and other traditional detection theory statistics, both the yes-no percent correct measure and the odds distributions generalize in an obvious and direct way to classification paradigms with more than two responses (e.g., identification).
TIME STEPPING FINITE ELEMENT ANALYSIS OF BROKEN BARS FAULT IN A THREE-PHASE SQUIRREL-CAGE INDUCTION MOTOR

Broken rotor bars and end-ring are common faults in three-phase squirrel-cage induction motors. These faults reduce the developed toque and increase the speed fluctuations of the motor. Meanwhile, developed unsymmetrical magnetic generates noise and vibration in the motor. Local heat around the broken bars may gradually breakthe adjacent bars and the motor will be finally out of service. Finite element method (FEM) is the most accurate technique for diagnosis and analysis of induction motor, because it can include all actual characteristics of the healthy and faulty induction motors. However, current density is generally considered as input for performance computation process, while fault can inject a large harmonics to the stator current. These harmonics may not be ignored in the fault diagnosis of the motor. In addition, all FE applications consider the steady-state mode of operation. In this paper, a three-phase voltage-fed squirrel-cage induction motor with rotor broken bars is proposed and analyzed for the starting period of the motor. Both no-load and on-load cases are considered. Also, concentrated rotor broken bars under one-pole and the distributed rotor broken bars under different poles are studied and compared.
Impact du Lab-score sur la prescription d'antibiotiques chez l'enfant avec état fébrile sans foyer

Le Lab-score, combinant les resultats de proteine C-Reactive (CRP), procalcitonine et stix urinaire, a demontre une excellente capacite de detection de l’infection bacterienne severe chez l’enfant avec etat febrile sans foyer. Notre etude visait a analyser son impact prospectif sur la reduction du taux de prescription d’antibiotiques chez l’enfant de 7 jours a 3 ans souffrant d’un etat febrile sans foyer. Malgre les excellentes caracteristiques diagnostiques du Lab-score, l’utilisation de ce dernier n’a pas montre d’efficacite sur la reduction de la prescription d’antibiotiques par rapport a un groupe controle d’enfants investigues selon les biomarqueurs usuels (globules blancs, neutrophiles immatures et CRP), essentiellement en raison de l’absence d’adherence aux recommandations du Lab-score. Appliquees strictement, une reduction significative du taux d’antibiotiques aurait pu etre observee tout en maintenant une excellente securite diagnostique. Renforcer l’education medicale et reviser les guidelines de prise en charge de l’etat febrile sans foyer chez l’enfant sont necessaire.
Detection of Malware and Malicious Executables Using E-Birch Algorithm

Malware detection is one of the challenges to the modern computing world. Web mining is the subset of data mining used to provide solutions for complex problems. Web intelligence is the new hope for the field of computer science to bring solution for the malware detection. Web mining is the method of web intelligence to make web as an intelligent tool to combat malware and phishing websites. Generally, malware injected through websites into the user system and modifies the executable file and paralyze the whole activity of the system. Antivirus application utilizes the data mining technique to find the malware in the web. There is a need of heuristic approach to solve the malware problem. Dynamic analysis methods yield better result than the static methods. Data mining is the best option for the dynamic analysis of malware or malicious program. The purpose of the research is to apply the enhanced Birch algorithm to find the malware and modified executables of Windows and Android operating system.
Developing a Vaccine for Non-Small-Cell Lung Cancer

History of Condition Many people believe that non–small-cell lung cancer (NSCLC) tumors are not good targets for active specifi c immunotherapy or vaccination because they have been generally considered low or nonimmunogenic, probably because they contain CD4+ CD25+ regulatory T-cells (so called “T-regs”), which are suppressive for cytotoxic lymphocyte (CTL) generation. Moreover, suitable target antigens in lung cancer have not yet been identifi ed. Therefore, several clinical trials for NSCLC are using autologous and/or allogeneic whole tumor cell-derived vaccines.
Optimizing DOP‐PCR for universal amplification of small DNA samples in comparative genomic hybridization

The standard comparative genomic hybridization (CGH) protocol relies on availability of macroscopic tumor samples, which do not contain too much interfering normal cells. Recently, CGH after universal amplification of genomic DNA with degenerate oligonucleotide primed PCR (DOP‐PCR) has been used to detect genetic aberrations in microdissected tumor specimens. However, owing to the technical difficulties, CGH results of only few microdissected samples have so far been published. We have developed an improved protocol for DOP‐PCR, which includes direct incorporation of fluorochrome‐conjugated nucleotides into the PCR product. Among the four polymerase enzymes tested, ThermoSequenase gave the best yield, with PCR products ranging from 100–4,000 bp. A two‐step PCR‐procedure was used, consisting of a preamplification with low stringency conditions followed by amplification in more stringent conditions. The method was first validated by hybridizing DOP‐PCR‐amplified normal DNA against nick‐translated reference DNA, which showed uniform and even hybridization result for all chromosomes. Comparison of DOP‐PCR CGH to conventional CGH in MCF‐7 breast cancer cell line further indicated that genetic aberrations can be reliably detected after DOP‐PCR amplification. The sensitivity of the DOP‐PCR‐CGH was tested by serial dilution of MCF‐7 DNA. Fifty picograms of sample DNA (corresponding roughly to two MCF‐7 cells) was sufficient for high quality CGH. Experiments with cells microdissected from intraductal breast cancer demonstrated that carcinoma cells from 1 to 2 ducts were sufficient for a successful DOP‐PCR CGH analysis. We conclude that the improved DOP‐PCR‐CGH protocol provides a powerful tool to study genetic aberrations in different histological subpopulations of malignant as well as precancerous lesions. DOP‐PCR also improves the success rate of conventional paraffin‐block CGH, because a poor quality or a too low yield of extracted DNA can be compensated by universal DNA amplification by DOP‐PCR. Genes Chromosom. Cancer 18:94–101, 1997. © 1997 Wiley‐Liss, Inc.
Body Temperature Measurements for Metabolic Phenotyping in Mice

Endothermic organisms rely on tightly balanced energy budgets to maintain a regulated body temperature and body mass. Metabolic phenotyping of mice, therefore, often includes the recording of body temperature. Thermometry in mice is conducted at various sites, using various devices and measurement practices, ranging from single-time probing to continuous temperature imaging. Whilst there is broad agreement that body temperature data is of value, procedural considerations of body temperature measurements in the context of metabolic phenotyping are missing. Here, we provide an overview of the various methods currently available for gathering body temperature data from mice. We explore the scope and limitations of thermometry in mice, with the hope of assisting researchers in the selection of appropriate approaches, and conditions, for comprehensive mouse phenotypic analyses.
Low back joint loading and kinematics during standing and unsupported sitting

The aim was to examine lumbar spine kinematics, spinal joint loads and trunk muscle activation patterns during a prolonged (2 h) period of sitting. This information is necessary to assist the ergonomist in designing work where posture variation is possible—particularly between standing and various styles of sitting. Joint loads were predicted with a highly detailed anatomical biomechanical model (that incorporated 104 muscles, passive ligaments and intervertebral discs), which utilized biological signals of spine posture and muscle electromyograms (EMG) from each trial of each subject. Sitting resulted in significantly higher (p< 0.001) low back compressive loads (mean±SD 1698±467 N) than those experienced by the lumbar spine during standing (1076±243 N). Subjects were equally divided into adopting one of two sitting strategies: a single ‘static’ or a ‘dynamic’ multiple posture approach. Within each individual, standing produced a distinctly diVerent spine posture compared with sitting, and standing spine postures did not overlap with flexion postures adopted in sitting when spine postures were averaged across all eight subjects. A rest component (as noted in an amplitude probability distribution function from the EMG) was present for all muscles monitored in both sitting and standing tasks. The upper and lower erector spinae muscle groups exhibited a shifting to higher levels of activation during sitting. There were no clear muscle activation level diVerences in the individuals who adopted diVerent sitting strategies. Standing appears to be a good rest from sitting given the reduction in passive tissue forces. However, the constant loading with little dynamic movement which characterizes both standing and sitting would provide little rest/change for muscular activation levels or low back loading.
Acute Effects of a Mixed Meal on Arterial Stiffness and Central Hemodynamics in Healthy Adults

Elevated central hemodynamics and arterial stiffness are associated with increased peripheral resistance and higher sympathetic nervous system activity. Additionally, consumption of a meal is known to be sympathoexcitatory. However, the acute effects of a meal on aortic wave reflection and stiffness are unknown. Therefore, we tested the hypothesis that aortic wave reflection and stiffness would increase following a meal. We examined these effects using high‐fidelity radial arterial pressure waveforms and carotid‐femoral pulse wave velocity (PWV), measured non‐invasively via applanation tonometry, before and 60 and 180 min after ingestion of a liquid mixed meal (Ensure, 40% of daily energy expenditure) in 15 healthy adults (25 ± 2 y; 8M/7F). Both peripheral and central pressures were reduced 180 min from baseline. Yet contrary to our hypothesis, augmentation index (15 ± 4 vs. 2 ± 3 vs. 8 ± 3%), augmentation index normalized for heart rate (9 ± 4 vs. −2 ± 3 vs. 3 ± 3%), augmented pressure (6 ± 2 vs. 1 ± 1 vs. 3 ± 1 mmHg) as well as carotid‐femoral PWV (7.3 ± 0.2 vs. 6.7 ± 0.2 vs. 6.7 ± 0.1 m/s) were substantially reduced at 60 and 180 min following the meal (P < 0.05 for all). Taken together, our results suggest that a liquid mixed meal acutely decreases central hemodynamics and arterial stiffness in healthy adults. NIH K23 DK82424 (TC) P30 DK50456 (MNOC) UL1 RR024150 (MCCTSA) HL105467 (DPC)