Miracle-dz/UniFAR-FTUs huggingface dataset:
New drugs for the treatment of agitation in schizophrenia: a systematic review and meta-analysis of inhaled loxapine and infused sodium nitroprusside

The use of novel drugs such as inhaled loxapine (LOXi) for schizophrenia and the off-label use of substances such as sodium nitroprusside (NIT) for the management of mental disorders require further investigation. We aimed to evaluate the efficacy and safety of LOXi and NIT for the treatment of agitation associated with schizophrenia. A systematic review of randomized controlled trials (RCTs) comparing the use of LOXi or NIT versus placebo or other antipsychotic agents was conducted, and we evaluated the efficacy (CGI-scale) and safety (adverse events) of the therapies. Altogether, 71 studies were identified, of which 2 (LOXi) were included in the meta-analysis, and 1 (NIT) was included in the systematic review only. The efficacy data showed superiority of LOXi against placebo, regardless of the dose (5 and 10 mg). No significant differences were observed concerning the safety results. Treatment with NIT showed favorable results, with significant reduction of the symptoms. The efficacy of these medications is difficult to assess because of the lack of RCTs. However, there is some information regarding the efficacy and safety of LOXi in the treatment of agitation in schizophrenic patients.
Effect of Drying and Hydrodistillation Time on the Amount of Ginger Essential Oil

The objective of this research is to study the effect of drying and hydrodistillation time on the amount of ginger ( Zingiber officinale Rosc.) essential oil. For this purpose, a hydrodistillation laboratory-scale extraction unit was employed. The fresh ginger were dried by air drying for 1, 2 and 4 days at ambient temperature. In general, ginger oil obtained in the form of bright yellow liquid with a distinctive aroma of ginger. The experimental results showed that the yields of the ginger essential oils were affected by the drying time of raw material and hydrodistillation times. The obtained essential oil was analyzed by gas chromatography–mass spectrometry and 12 compounds were identified. The major compounds of ginger essential oil were 1,8-cineole, geranial, geraniol, camphene and neral.
High-resolution underway measurements of phytoplankton photosynthesis and abundance as an innovative addition to water quality monitoring programs

Abstract. Marine waters can be highly heterogeneous both on a spatial and temporal scale, yet monitoring programs currently rely primarily on low-resolution methods. This potentially leads to undersampling. This study explores the potential of two high-resolution methods for monitoring phytoplankton dynamics: fast repetition rate fluorometry for information on phytoplankton photosynthesis and productivity and automated scanning flow cytometry for information on phytoplankton abundance and community composition. These methods were tested in combination with an underway Ferrybox system during four cruises on the Dutch North Sea in April, May, June, and August 2017. The high-resolution methods were able to visualize both the spatial and temporal variability of the phytoplankton community in the Dutch North Sea. Spectral cluster analysis was applied to objectively interpret the multitude of parameters and visualize potential spatial patterns. This resulted in the identification of biogeographic regions with distinct phytoplankton communities, which varied per cruise. Our results clearly show that the sampling based on fixed stations does not give a good representation of the spatial patterns, showing the added value of underway high-resolution measurements. To fully exploit the potential of the tested high-resolution measurement setup, methodological constraints need further research. Among these constraints are accounting for the diurnal cycle in photophysiological parameters concurrent to the spatial variation, better predictions of the electron requirement for carbon fixation to estimate gross primary productivity, and the identification of more flow cytometer clusters with informative value. Nevertheless, the richness of additional information provided by high-resolution methods can improve existing low-resolution monitoring programs towards a more precise and ecosystemic ecological assessment of the phytoplankton community and productivity.
A Comparison of Continuous Performance Tasks Using Cognitive Versus Sensory Stimuli

A comparison of continuous performance tasks (CPTs) using cognitive versus sensory stimuli was undertaken to compare vigilance performance on analogous verbal and non-verbal tasks in normal , young adults . Eighty-nine introductory psychology students , screened for head injury, neurological deficits, and medication and substance use performed two versions of an auditory , computerized CPT. In the verbal task , stimuli were letters of the alphabet, whereas in the non-verbal task , they were tones of the major diatonic scale . During each 15 min task , 1200 stimuli were presented at an onset -to-onset time of0 . 75 sec. A total of 100 targets was presented in semi-random sequence at an average rate of one every 9 sec. Targets were constituted by stimuli that were identical to the immediately preceding stimulus . Participants were required to respond to targets with the press of a hand-held button . Results indicated significant differences between the two versions of the task on accuracy, adjusted accuracy , and false alarm rate. In addition, correlations were found both within and between the tasks for accuracy, adjusted accuracy , and reaction time . Implications of these results for models of attention , theories of laterality and attentional mechanisms, and clinical use are discussed .
Impact of reference population and marker density on accuracy of population imputation

The effect of the reference population size and the number of missing single nucleotide polymorphisms (SNPs) on imputation accuracy was determined. The population imputation method using the FImpute software was applied. The dataset used for the purpose of this study was taken from the database of the Holstein Cattle Breeders Association of the Czech Republic. It contains 1000 animals genotyped with the Illumina BovineSNP50 v.2 BeadChip. Two datasets were created, the first containing the original genotypes, including the missing SNPs, the second containing the same genotypes modified to avoid missing data. In these datasets, animals were randomly selected for a reference population (10, 25, 50 and 75%) and there were randomly selected SNPs for deletion (15, 30, 55, 70, and 95%) in animals that were not used as the reference population. Subsequently, the data accuracy was determined by two parameters: correlation between original and imputed SNPs and percentage of correctly imputed SNPs. Since animals and SNPs were randomly selected, the process including data imputation was repeated 100 times. Accuracy was determined as the average accuracy over all repetitions. It was found that the imputation accuracy is influenced by both parameters. If the size of the reference population is sufficient, the imputation accuracy is higher despite the large number of missing SNPs.
The effect of ownership structure to tax aggressiveness: evidence from Greece

This dissertation was written as part of the MSc in International Accounting, Auditing and Financial Management at the International Hellenic University. In this study, I consider critically the effects of ownership on tax aggressiveness. I analyze the importance of tax avoidance and the weight that public opinion gives in these days and we focus our survey on Greek listed companies during the period of crisis (2010-2014). Ι summarize the literature on tax aggressiveness focusing in the measurement, the decisive factors and the results of tax avoidance. Then Ι investigate the role of ownership structure in tax avoidance. Ι divide ownership structure into family business, government ownership and foreign ownership and we investigate each one separately. For our research Ι use two samples of 165 and 121 listed companies from the Athens Stock Exchange. Ι used two samples because we wanted to have a wider look at all of the ASE categories and a narrow one on the Main Market. The results point out there is no statistical relation between ownership structures above and tax aggressiveness. At this point I would like to thank Dr. Stergios Leventis, as my supervisor, and Dr. Alexandros Sikalidis, as my mentor, for their guidance in the realization of this dissertation. Also, my family, colleagues and friends (especially Egor Gios) for their help and support during the master period.
EVALUATION OF AGRICULTURE’S ECONOMIC ROLE IN EU COUNTRIES

In this paper we investigate the position of agric ulture in the economy of EU countries. Agriculture in the EU is highly heteroge neous – we characterise the sector by using the share of agriculture workers of total employment, the share of agriculture in total GDP, and the value added in agriculture per worker. To quantify the economic importance of agriculture per country for acquired specific condition, we construct the Agricultural Index-Tota l (AGRIT) and Agricultural Index (AGRI). We utilize the fuzzy set theory to co ntribute to the correct quantification of a country gap from the aimed-for condit ion of agricultural position. Using cluster analysis, we identify those countries with a similar position in agriculture. We test the efficacy of EU agrarian po licy with the verification of sigma and beta convergence. The Eurostat database p rovides data for the evaluated 2005 – 2015 period.
THE VALUE OF RESTATEMENT TO FRAUD PREDICTION

A financial report restatement reflects errors in the previous financial statement, and thus it increases investors’ doubt about the credibility of the financial statement. The primary objective of this paper is to examine whether restatement announcements imply increased fraud risks in Chinese firms in the context that up to one quarter of listed companies have restated their financial reports in China, and explore the implications of the content, severity and reasons for restatements with respect to fraud. In this paper, firms with financial restatements prove to be more likely to be labeled as fraudulent by regulators in China. Second, the following results also are revealed: (1) financial statements, except balance sheet restatements, provide insights into the revelation of fraudulent behaviors, (2) the severity of restatements is positively correlated with future fraud disclosures, and (3) restatements due to negligence are positively correlated with future fraud occurrences. These results imply that restatement announcements and their different characteristics provide important information for detecting financial statement fraud.
A robustness approach to theory building : A case study of language evolution

Models of cognitive processes often include simplifications, idealisations, and fictionalisations, so how should we learn about cognitive processes from such models? Particularly in cognitive science, when many features of the target system are unknown, it is not always clear which simplifications, idealisations, and so on, are appropriate for a research question, and which are highly misleading. Here we use a case-study from studies of language evolution, and ideas from philosophy of science, to illustrate a robustness approach to learning from models. Robust properties are those that arise across a range of models, simulations and experiments, and can be used to identify key causal structures in the models, and the phenomenon, under investigation. For example, in studies of language evolution, the emergence of compositional structure is a robust property across models, simulations and experiments of cultural transmission, but only under pressures for learnability and expressivity. This arguably illustrates the principles underlying real cases of language evolution. We provide an outline of the robustness approach, including its limitations, and suggest that this methodology can be productively used throughout cognitive science. Perhaps of most importance, it suggests that different modelling frameworks should be used as tools to identify the abstract properties of a system, rather than being definitive expressions of theories.
ON CERTAIN OPTIMAL HOMEOMORPHISMS BETWEEN CLOSED CURVES

The concept of natural pseudo-distance has proven to be a powerful tool for measuring the dissimilarity between shape properties of topological spaces, modeled as continuous real-valued functions defined on the spaces themselves. Roughly speaking, the natural pseudo-distance is defined as the infimum of the change of the functions’ values, when moving from one space to the other through homeomorphisms, if possible. In this paper, we prove the first available result about the existence of optimal homeomorphisms between closed curves, i.e. inducing a change of the function that equals the natural pseudo-distance.
Professional status and well-being in healthcare organizations

This paper aims to explore what aspects of work-life affect healthcare professionals’ well-being and if these aspects may explain a possible categorization considering different professional status. We administered a slightly altered version of the Copenhagen Psychosocial Questionnaire to assess the well-being of patient care workers in a government-funded healthcare organization in Southern Italy. Then, we run an analysis of variance test to explore the aspects affecting the well-being of patient care workers, and to understand if these aspects vary per different professional status (physicians, nurses, and health technicians). Results show important differences among the various professional categories of patient care workers, thus providing the basis for reflections and interventions to improve employee well-being, relevant from a theoretical, practical, and above all policy-making perspectives.
Controlled Braking for Omnidirectional Wheels

Due to their design omnidirectional wheels in general lack the capability to generate substantial side forces - forces perpendicular to the roller axis. This is caused by the free rolling rollers around the circumference, the very same thing that allows holonomic movement. An interesting consequence is that when an omnidirectional p latform undergoes heavy braking, due to uneven wheel load or other disturbances, the vehicle has a tendency to swerve. An o mnid irectional p latform is a comp lex nonlinear system, where the nonlinearit ies come fro m the wheel material and construction, and the unidirectional force generation capability. In this article a correct ive controller is described that prevents swerving even in the presence of high uncertainties. The operation and disturbance rejection of the controller is demonstrated by simu lation in Modelica- Dy mo la environment.
Genetic diversity and forest reproductive material - from seed source selection to planting

Abstract: How much of genetic diversity is desirable in mass production of forest reproductive material? How mass production of forest reproductive material reduces genetic diversity? Relation between genetic diversity and mass production of forest reproductive material is discussed in a holistic manner. In industrial forest plantations, narrow genetic diversity is desirable and reproductive material is produced at clone level. On the other hand, in conservation forestry a wide genetic diversity is imperative. Beside management goals, a desirable level of genetic diversity is related to rotation cycle and ontogeny of tree species. Risks of failure are lower in short rotations of fast growing species. In production of slow growing species, managed in long rotations, the reduction of genetic diversity increases the risk of failure due to causes unknown or unexpected at the time of planting. This risk is additionally increased in cases of seed transfer and in conditions of climate change. Every step in production of forest reproductive material, from collection to nursery production, has an effect on genetic diversity mainly by directional selection and should be considered. This review revealed no consistent decrease of genetic diversity during forest reproductive material production and planting.
Perspectives on Improved Therapy of Septicemia by Rapid Bacterial Identification Using MALDI-TOF MS and Rapid Susceptibility Testing

The most serious clinical manifestations of bloodstream infections (BSI), sepsis and septic shock, are urgent conditions requiring prompt initiation of adequate antimicrobial therapy [1]. In septic shock, every hour of delayed upstart of effective antimicrobial therapy was associated with a decrease in survival rate, thus falling from 82.7% initially to 42% after six hours of hypotension duration [2]. Rapid identification of microorganisms directly from blood cultures after flagging positive is the first step in shortening the diagnostic process. A number of molecular methods for direct identification from blood cultures have been described, including multiplex real-time PCR [3]. After matrixassisted laser desorption ionizationtime of flight (MALDI-TOF) mass spectrometry (MS) was introduced in microbiological laboratories in the last decade [4], development of rapid in-house [5,6] and commercial methods (Sepsityper Kit, Bruker Daltonics, Germany) for direct identification of organisms from positive blood cultures have been reported.
Strain Gauge: study of strain distributions around three Morse taper prosthetic connections with offset positioning in machined and plastic copings under vertical load

The aim of this study was to evaluate through strain gauge the strain distribution occurred around 3 Morse taper implants with positioning offset, by varying the types of copings: plastic and machined. Microunit prosthetic abutments were connected onto the implant platforms. Ten frameworks composed of 3 copings were casted in cobalt-chromium alloy as single block (Co-Cr). Half of the copings were machined (n=5) and half were made of plastics (n=5). Four strain gauges were placed into the polyurethane block tangential to the 3 implants. The frameworks were fixed at their respective sites with the aid of a retaining screw with torque of 20 N.cm, achieve with a mechanical torquemeter. The vertical load of 30 Kg was applied through a spherical point of 2 mm diameter for 10 s, onto each one of the 3 screws of the framework through a device for load application The records of the strain reading were submitted to ANOVA and Tukey tests (5%). There were statistically significant differences (p=0.0174) between the coping type used (machined and plastic). The micro strain mean values were: point C at the machined coping 282.5 μm (±120.8), point B at the machined coping 229.5 μm (±76.1), point A at the machined coping 209.8 μm (±55.0), point C at the plastic coping 155.0 μm (±30.5), point B at the plastic coping 146.2 μm (±25.8) and point A at the plastic coping 130.36 μm (±21.83). It was concluded that there was a significant difference between the coping types, once the plastic coping exerted smaller micro strain on Morse taper implants than the machined copings.
A metric characterization of manifolds with boundary

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Redistribution of CO at the location of the CO ice line in evolving gas and dust disks

Context. Ice lines are suggested to play a significant role in grain growth and planetesimal formation in protoplanetary disks. Evaporation fronts directly influence the gas and ice abundances of volatile species in the disk and therefore the coagulation physics and efficiency and the chemical composition of the resulting planetesimals. Aims. In this work, we investigate the influence of the existence of the CO ice line on particle growth and on the distribution of CO in the disk. Methods. We include the possibility of tracking the CO content and/or other volatiles in particles and in the gas in our existing dust coagulation and disk evolution model and present a method for studying evaporation and condensation of CO using the Hertz-Knudsen equation. Our model does not yet include fragmentation, which will be part of further investigations. Results. We find no enhanced grain growth immediately outside the ice line where the particle size is limited by radial drift. Instead, we find a depletion of solid material inside the ice line, which is solely due to evaporation of the CO. Such a depression inside the ice line may be observable and may help to quantify the processes described in this work. Furthermore, we find that the viscosity and diffusivity of the gas heavily influence the re-distribution of vaporized CO at the ice line and can lead to an increase in the CO abundance by up to a factor of a few in the region just inside the ice line. Depending on the strength of the gaseous transport mechanisms, the position of the ice line in our model can change by up to ~ 10 AU and consequently, the temperature at that location can range from 21 to 23 K.
The determinant factors of efficiency on Islamic banking and conventional banking in Indonesia

As intermediary institutions, conventional banks have larger amount of loans to third party funds than of Sharia banks. Thus, the bank needs a performance appraisal to measure banking operations through efficiency. We examine the efficiency of Islamic banks and conventional banks in Indonesia and analyzes the factors that influence the level of efficiency known as the Two-Stage Data Envelopment Analysis method. We found that there are significant efficiency differences between Islamic banking and conventional banking in the 1 st quarter 2014- 4 th quarter 2017. On the other hand, NPF and NPL results affected negatively towards Islamic and conventional banks efficiency. Asset and CAR affected positively significant toward Islamic banks efficiency. Asset and ROA had affected positively significantly toward conventional banks efficiency but CAR had affected positively insignificantly toward conventional banks. Lastly, ROA had affected positively insignificantly toward Islamic banks efficiency. JEL Classification: G31, G32, G33 DOI : https://doi.org/10.26905/jkdp.v23i3. 3157
Biorthogonal quantum mechanics

The Hermiticity condition in quantum mechanics required for the characterization of (a) physical observables and (b) generators of unitary motions can be relaxed into a wider class of operators whose eigenvalues are real and whose eigenstates are complete. In this case, the orthogonality of eigenstates is replaced by the notion of biorthogonality that defines the relation between the Hilbert space of states and its dual space. The resulting quantum theory, which might appropriately be called ‘biorthogonal quantum mechanics’, is developed here in some detail in the case for which the Hilbert-space dimensionality is finite. Specifically, characterizations of probability assignment rules, observable properties, pure and mixed states, spin particles, measurements, combined systems and entanglements, perturbations, and dynamical aspects of the theory are developed. The paper concludes with a brief discussion on infinite-dimensional systems.