Miracle-dz/UniFAR-FTUs huggingface dataset:
Neighborhood Socioeconomic Status Predicts Health After Hospitalization for Acute Coronary Syndromes: Findings From TRACE-CORE (Transitions, Risks, and Actions in Coronary Events—Center for Outcomes Research and Education)

Objective: To explore the influence of contextual factors on health-related quality of life (HRQoL), which is sometimes used as an indicator of quality of care, we examined the association of neighborhood socioeconomic status (NSES) and trajectories of HRQoL after hospitalization for acute coronary syndromes (ACS). Methods: We studied 1481 patients hospitalized with acute coronary syndromes in Massachusetts and Georgia querying HRQoL via the mental and physical components of the 36-item short-form health survey (SF-36) (MCS and PCS) and the physical limitations and angina-related HRQoL subscales of the Seattle Angina Questionnaire (SAQ) during hospitalization and at 1-, 3-, and 6-month postdischarge. We categorized participants by tertiles of the neighborhood deprivation index (a residence-census tract-based measure) to examine the association of NSES with trajectories of HRQoL after adjusting for individual socioeconomic status (SES) and clinical characteristics. Results: Participants had mean age 61.3 (SD, 11.4) years; 33% were female; 76%, non-Hispanic white; 11.2% had household income below the federal poverty level. During 6 months postdischarge, living in lower NSES neighborhoods was associated with lower mean PCS scores (1.5 points for intermediate NSES; 1.8 for low) and SAQ scores (2.4 and 4.2 points) versus living in high NSES neighborhoods. NSES was more consequential for patients with lower individual SES. Individuals living below the federal poverty level had lower average MCS and SAQ physical scores (3.7 and 7.7 points, respectively) than those above. Conclusions: Neighborhood deprivation was associated with worse health status. Using HRQoL to assess quality of care without accounting for individual SES and NSES may unfairly penalize safety-net hospitals.
Energy-coupled transport across the outer membrane of Escherichia coli: ExbB binds ExbD and TonB in vitro, and leucine 132 in the periplasmic region and aspartate 25 in the transmembrane region are important for ExbD activity

Ferric siderophores, vitamin B12, and group B colicins are taken up through the outer membranes of Escherichia coli cells by an energy-coupled process. Energy from the cytoplasmic membrane is transferred to the outer membrane with the aid of the Ton system, consisting of the proteins TonB, ExbB, and ExbD. In this paper we describe two point mutations which inactivate ExbD. One mutation close to the N-terminal end of ExbD is located in the cytoplasmic membrane, and the other mutation close to the C-terminal end is located in the periplasm. E. coli CHO3, carrying a chromosomal exbD mutation in which leucine at position 132 was replaced by glutamine, was devoid of all Ton-related activities. A plasmid-encoded ExbD derivative, in which aspartate at position 25, the only changed amino acid in the predicted membrane-spanning region of ExbD, was replaced by asparagine, failed to restore the Ton activities of strain CHO3 and negatively complemented ExbD+ strains, indicating an interaction of this mutated ExbD with wild-type ExbD or with another component. This component was shown to be ExbB. ExbB that was labeled with 6 histidine residues at its C-terminal end and that bound to a nickel-nitrilotriacetic acid agarose column retained ExbD and TonB specifically; both were eluted with the ExbB labeled with 6 histidine residues, demonstrating interaction of ExbB with ExbD and TonB. These data further support the concept that TonB, ExbB, and ExbD form a complex in which the energized conformation of TonB opens the channels in the outer membrane receptor proteins.
he role of integrated backscatter intravascular ultrasound in haracterizing bare metal and drug-eluting stent restenotic neointima s compared to optical coherence tomography

Background: To evaluate the role of integrated backscatter intravascular ultrasound (IB-IVUS) in assessing the morphology of neointima in bare-metal stent (BMS) and drug-eluting stent (DES) restenosis as compared to the gold-standard, optical coherence tomography (OCT). Methods: A total of 120 cross-sections were evaluated by IB-IVUS and OCT at five cross-sections from 24 patients (24 lesions): at the minimal lumen area (MLA) and at 1 and 2 mm proximal and distal to the MLA site in 24 lesions (9 treated with DES and 15 treated with BMS). IB-IVUS and OCT findings were analyzed according to the time at which restenosis was identified (early <12 months and late ≥12 months) and the stent type. Results: IB-IVUS was found to correctly characterize the neointima of both BMS and DES in-stent restenosis (ISR) as compared to OCT. The overall agreement between the pattern of ISR neointima by IB-IVUS and that by OCT was excellent (kappa = 0.85, 95% CI 0.76–0.94). Late DES ISR was characterized by more nonhomogeneous, low backscatter and lipid-laden neointima, as compared to the BMS equivalent (BMS vs. DES, 45.0% vs. 80.0%, p < 0.01; 51.7% vs. 85.0%, p = 0.008; 33.3% vs. 65.0%, p < 0.01, respectively). Conclusions: IB-IVUS assessment of the ISR neointima pattern appears to provide similar information as the gold-standard OCT in patients with stable angina. Both modalities suggested that late DES restenosis is characterized by a non-homogeneous lipid-laden neointima. © 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
High-Gain Fully Printed Organic Complementary Circuits on Flexible Plastic Foils

We present several fully printed organic complementary circuits using n- and p-type organic thin-film transistors. n-Type and p-type devices are developed on a flexible polyethylene-naphthalate substrate. All organic layers are deposited using a low-cost screen-printing technique. The inverters show a high gain and a switching point at exactly VDD/2. A seven-stage voltage-controlled oscillator (VCO) is designed with an organic output buffer, using the n- and p-type organic transistors. This VCO oscillates at a frequency of 186 Hz. Finally, two complementary differential amplifiers with high gain and large bandwidth are presented. The amplifiers only draw a 1-μA current from a 40-V power supply.
High performance acetylene sensor based on ZnO/reduced graphene oxide nanocomposite

Sensing of acetylene (C2H2) has been carried out through synthesizing ZnO/reduced graphene oxide (rGO) nanocomposite using a solvothermal method with graphene oxide (GO) and Zn(NO3)2.6H2O as the precursors. The morphology, crystal structure, and the compositional analysis of the synthesized materials were characterized by field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The physical properties of the as-synthesized material exhibited rGO layers assorted with tiny ZnO nanoparticles (NPs), where rGO supposedly acted as a template in the synthesis process for promoting the preferential attachment of ZnO nanoparticles with rGO sheets and preventing agglomeration of the ZnO nanoparticles without significantly changing its morphology and crystal structure. From the experimental results, it was evident that the synthesized nanocomposite had a preferential detection of C2H2 gas with a high response value of 34%, good selectivity, low detection limit (30 ppm), and response/recovery time of ~ 100/28 sec at 250oC. The results suggested that graphene oxide (GO) addition might be an effective method for improving C2H2 sensing performance of the ZnO based sensors which may provide challenges as well as more opportunities in the near future.
Results from Australia's 2014 Report Card on Physical Activity for Children and Youth.

BACKGROUND Like many other countries, Australia is facing an inactivity epidemic. The purpose of the Australian 2014 Physical Activity Report Card initiative was to assess the behaviors, settings, and sources of influences and strategies and investments associated with the physical activity levels of Australian children and youth. METHODS A Research Working Group (RWG) drawn from experts around Australia collaborated to determine key indicators, assess available datasets, and the metrics which should be used to inform grades for each indicator and factors to consider when weighting the data. The RWG then met to evaluate the synthesized data to assign a grade to each indicator. RESULTS Overall Physical Activity Levels were assigned a grade of D-. Other physical activity behaviors were also graded as less than average (D to D-), while Organized Sport and Physical Activity Participation was assigned a grade of B-. The nation performed better for settings and sources of influence and Government Strategies and Investments (A- to a C). Four incompletes were assigned due to a lack of representative quality data. CONCLUSIONS Evidence suggests that physical activity levels of Australian children remain very low, despite moderately supportive social, environmental and regulatory environments. There are clear gaps in the research which need to be filled and consistent data collection methods need to be put into place.
Differential release of mast cell mediators and the pathogenesis of inflammation

Summary: Mast cells are well known for their involvement in allergic and anaphylactic reactions, during which immunoglobulin E (IgE) receptor (FcɛRI) aggregation leads to exocytosis of the content of secretory granules (1000 nm), commonly known as degranulation, and secretion of multiple mediators. Recent findings implicate mast cells also in inflammatory diseases, such as multiple sclerosis, where mast cells appear to be intact by light microscopy. Mast cells can be activated by bacterial or viral antigens, cytokines, growth factors, and hormones, leading to differential release of distinct mediators without degranulation. This process appears to involve de novo synthesis of mediators, such as interleukin‐6 and vascular endothelial growth factor, with release through secretory vesicles (50 nm), similar to those in synaptic transmission. Moreover, the signal transduction steps necessary for this process appear to be largely distinct from those known in FcɛRI‐dependent degranulation. How these differential mast cell responses are controlled is still unresolved. No clinically available pharmacological agents can inhibit either degranulation or mast cell mediator release. Understanding this process could help develop mast cell inhibitors of selective mediator release with novel therapeutic applications.
Oral hygiene and oral health status of the nursing students in Turkey

Bu çalışmada, Türkiye'nin beş farklı demografik bölgesinde ki kız öğrenci populasyonunu temsil eden, hemşirelik okulu öğrencilerinin, ağız hijyeni ve ağız sağlığı durumlarının belirlenmesini amaçladık. Gülhane Askeri Tıp Akademisi Hemşirelik Yüksek Okulundaki (18-22 yaşlarında) üç yüz yirmi beş kız öğrenci çalışmaya dahil edildi. Öğrencilerin ağız içi muayeneleri yapıldı, genel tıbbi öyküleri ve oral hijyen uygulamalarına ilişkin görüşüldü. Öğrencilerin sadece küçük bir kısmı (%4.6) sigara kullanıyordu. Plak kontrolü %82.8’inin çok iyi ve %17.2’sinin iyiydi. Bununla birlikte, öğrencilerdeki diş çürükleri ve sonuçları, yüksek çürükeksik-dolgulu diş (decayed missing filled tooth) skoru değerleri ile nispeten yaygın bir sorundu. Dentin hassasiyeti %32.9’unda saptandı. Öğrencilerin 13’üne (%4) periodontitis tanısı konuldu. Öğrencilerin küçük bir yüzdesinde Orta (%6.5) veya şiddetli (%0.6) gingivitis görülürken hafif gingivitis (%35.1) oldukça yaygındı. Ağız hijyeni davranışları hemşirelik öğrencilerinin bu grubunda oldukça iyiydi. Bununla birlikte, diş çürükleri, hafif gingivitis ve dentin hassasiyeti öğrenci populasyonunu etkileyen ortak sorunlardandı. Bu bulguları ortadan kaldırmak için ağız sağlığı programları ve rutin diş hekimi ziyaretleri teşvik edilmelidir.
John Woolman's Path to the Peaceable Kingdom: A Quaker in the British Empire

Introduction 1. Past Ages: History 2. Deserts and Lonely Places: Social Diversion and Solitary Meditation 3. More Than Was Required: Quaker Meetings 4. The Road to Large Business: Family and Work 5. A Dark Gloominess Hanging over the Land: Slavery 6. Men in Military Posture: The Seven Years' War 7. Not in Words Only: Conspicuous Instructive Behavior 8. The Deep: Crossing the Sea 9. A Messenger Sent from the Almighty: England and Death Epilogue List of Abbreviations Notes Index Acknowledgments
3D cell assembly based on electro deposition of calcium alginate

Cell assembly is a key technique for tissue engineering and the creation of organs. However, the current techniques are mainly focusing on the cell culture on a flat plate, which environment is different from the in vivo. In this paper, we proposed a direct writing method for 3D cell assembly based on the electrode deposition of calcium alginate. Sodium alginate solution (1%) with suspended CaCO3 particles (0.2%) are prepared and put on ITO plate substrate. One tungsten probe and the ITO plate are used as the anode and cathode respectively. By applying voltage on the electrodes, the gel will be formed on the tungsten probe. Therefore, gel with arbitrary shape can be written directly by controlling the position the tungsten probe. The reaction speed is controlled by adjusting the current density. The current results show the gel line can be written successfully with the moveable anode.
Multiple attractors and bifurcations in Hard oscillators Driven by Constant inputs

Hard oscillators are dynamical systems that show the coexistence of qualitatively different attractors, in the form of limit cycles and equilibrium points. In the presence of external inputs their dynamic behavior is significantly different from those of oscillators, called soft, with a limit cycle as unique attractor. This paper studies the dynamics of a simple hard oscillator under the influence of a constant external input. It is shown that, despite the apparent simplicity, when the input strength and the oscillator's natural frequency are varied the system exhibits many different bifurcation phenomena, including global bifurcations as saddle-node on limit cycle and homoclinic bifurcations. The model under investigation can play a role in neuroscience, as it exhibits two different mechanisms of class I neural excitability and one mechanism for class II. It also highlights a mechanism of transition between the two classes.
3-Methyladenine-DNA glycosylase I from Escherichia coli-computer modeling and supporting experimental evidence.

TagA (3-methyladenine-DNA glycosylase I) excises 3-methyadenine and 3-methylguanine from alkylated DNA. The structure of this enzyme has not yet been determined experimentally. We propose a three-dimensional model of the TagA protein based on the threading algorithm. The model shows that TagA is a mostly alpha-helical protein, in agreement with circular dichroism measurements. None of the eight cysteines present in the TagA sequence forms a disulfide bridge in the model structure, which has also been experimentally verified with the use of Ellman method.
Surface Plasmon Resonance characteristic study of graphene-on-gold structure

In this paper, we carried out an experimental study of graphene-on-gold structure based on Surface Plasmon Resonance Imaging (SPRI) method. To our knowledge, this is the first experimental report of graphene SPR study. An experimental SPRI platform was setup, which can fulfill wide incident angle range covering the resonant angle of gas and aqueous sample. 1, 2, 3 layers of graphene are fabricated by CVD method and then transfer to gold substrate. The SPR images of different graphene-on-gold structure are acquired and analyzed. SPR curves of different layers of graphene-on-gold are obtained and compared with simulation result. It is found that the SPR angle will shift about 0.18(deg) per graphene layer, which is consistent with the simulation result (0.15 deg). The graphene-on-gold structure provide an accurate single-atom-layer tool, which can be applied in various research areas, e.g. biosensor, nanoplasmonic etc.
Tenascin: cDNA cloning and induction by TGF‐beta.

cDNA clones coding for tenascin, an extracellular matrix glycoprotein with a restricted tissue distribution, were isolated from a chicken fibroblast cDNA expression library using a specific tenascin antiserum. Antibodies eluted from the cDNA‐encoded fusion proteins reacted exclusively with tenascin. Limited trypsin treatment of purified tenascin resulted in a peptide which confirmed the deduced protein sequences. The largest clone encoding 632 amino acids showed a cysteine‐rich region containing 13 consecutive epidermal growth factor‐like repeats of unusual uniformity. Northern blot analysis revealed 8‐ to 9‐kb messages. Tenascin is shown to be induced in vitro by fetal calf serum as well as by transforming growth factor beta (TGF‐beta). A 4‐fold increase in tenascin secretion by chick embryo fibroblasts was seen after TGF‐beta treatment. The induction of tenascin protein synthesis was preceded by an increase of tenascin mRNA as determined by Northern blot analysis. The induction of tenascin was compared with fibronectin. The accumulation of the two extracellular matrix proteins in the medium was differentially affected by fetal calf serum and TGF‐beta and the increase was in both cases higher for tenascin.
Object Persistence

Almost every application needs a way to make its data persistent. Even the simplest application usually has at least some settings that need to be stored. There are a lot of ways to achieve this and their suitability depends on the amount of data to be stored, the complexity of that data and performance requirements. This report is meant to be an overview of different techniques to achieve the much needed object persistence in an application. The report is written from a application developer perspective. The underlying application is assumed to be a web shop and therefore does not discuss aspects of object persistence present in embedded systems. The report will also introduce the reader to the Data Access Object design pattern. This design pattern makes it easier to migrate an application between different persistence implementations. The object persistence techniques within the report touches varied technologies such as binary files, XML and XQuery, relational database and sql, object-relational mapping tools and object oriented databases. Using a relational database together with a potent object-relational is well suited for developing high concurrency systems such as the web-shop application. The different technologies are presented and discussed at a high level arguing strengths and weaknesses. The bottom line of this report is that the choice of persistence technique should always be based on the needs and requirements of the application.
Endoscopic ultrasonography: imaging and beyond

Endoscopic ultrasonography (EUS), introduced into gastroenterological diagnostics more than 20 years ago, has undergone extensive evaluation of its diagnostic capability, probably to a larger extent than most other endoscopic and other imaging techniques in gastroenterology. Almost necessarily, as to be expected with an imaging method being assessed with continuing interest for two decades, initial enthusiasm has waned and questions about its influence on management and outcome have been dealt with, yielding mixed results. Other imaging techniques are usually not burdened by such a self critical approach, mostly due to the fact that technical progress has hindered proper evaluation, and techniques are marketed with only little good evidence of their real value. Methodological questions about study quality in gastrointestinal imaging have attracted limited interest, and only rarely are factors looked into, which may be responsible for divergent study results.1 However, it happened a few years ago that EUS was revitalised, mainly due to the advent of EUS guided fine needle aspiration (FNA),2 and even more recently, several emerging techniques of EUS guided therapy.3 The following does not aim at giving a full overview on the ever rising body of literature on the accuracy of diagnostic EUS, including FNA. For this purpose textbooks and review articles in various journals2,4 are recommended. Some current trends and possible future tendencies will be outlined. Echoendoscopes—with some recent exceptions—are oblique viewing endoscopes which carry a rigid ultrasound transducer at their tip, which either generates a 360° round view perpendicular to the shaft axis or a linear image of variable width parallel to the endoscope axis. Radial scanners have been mechanical scanners but recently electronic scanning—the principle of linear scanners—is being developed for radial scanning also. EUS utilises high ultrasound frequencies (5–20 MHz, 7.5 MHz being the most frequently used ultrasound frequency) …
Introduction to Communication Complexity

In this essay, we give a basic introduction to the exciting eld of communication complexity. Communication complexity was rst formalized by Yao in 1979 [3]. e context is easy enough to understand: two parties (usually named Alice and Bob) wish to compute the value of some function f of two variables. Alice knows the value of one of the variables, while Bob knows the value of the other. How much must Alice and Bob communicate in order to nd the value of f on their combined input? Since Yao’s seminal work on the subject, the eld of communication complexity has exploded. is growth is driven by the eld’s diverse applications to computational complexity and connections to other branches of discrete math and computer science. Our brief exposition here is inspired by Yao’s original work, but is strongly inuenced by Kushilevitz and Nisan’s more modern treatise on communication complexity [1]. We focus on a deterministic theory of communication, although we hint at other models in the nal section. is essay is broken into four modules. In the rst, we formalize the notion of a communication protocol and dene the communication complexity of a function. e bulk of the theoretical material resides in the second section, where we give techniques for proving communication lower bounds. In the third section we apply the techniques of the previous section to prove lower bounds for particular functions. In the nal section, we give examples that suggest other models of communication.
TILLING Mutants of Lotus japonicus Reveal That Nitrogen Assimilation and Fixation Can Occur in the Absence of Nodule-Enhanced Sucrose Synthase[C][W]

In all plant species studied to date, sucrose synthase occurs as multiple isoforms. The specific functions of the different isoforms are for the most part not clear. Six isoforms of sucrose synthase have been identified in the model legume Lotus japonicus, the same number as in Arabidopsis (Arabidopsis thaliana) and rice (Oryza sativa). The genes encoding these isoforms are differentially expressed in all plant organs examined, although one, LjSUS4, is only expressed in flowers. LjSUS1 is the most highly expressed in all plant organs tested, except root nodules, where LjSUS3 accounts for more than 60% of the total SUS transcripts. One gene, LjSUS2, produces two transcripts due to alternative splicing, a feature not observed in other species to date. We have isolated plants carrying ethyl methanesulfonate-induced mutations in several SUS genes by targeting-induced local lesions in genomes reverse genetics and examined the effect of null alleles of two genes, LjSUS1 and LjSUS3, on nodule function. No differences were observed between the mutants and wild-type plants under glasshouse conditions, but there was evidence for a nitrogen-starvation phenotype in the sus3-1 mutant and severe impairment of growth in the sus1-1/sus3-1 double mutant under specific environmental conditions. Nodules of sus3-1 mutant plants retained a capacity for nitrogen fixation under all conditions. Thus, nitrogen fixation can occur in L. japonicus nodules even in the absence of LjSUS3 (the major nodule-induced isoform of SUS), so LjSUS1 must also contribute to the maintenance of nitrogen assimilation.