Miracle-dz/UniFAR-FTUs huggingface dataset:
Material-Driven Fibronectin Assembly Rescues Matrix Defects due to Mutations in Collagen IV in Fibroblasts

Basement membranes (BMs) provide structural support to tissues and influence cell signaling. Mutations in COL4A1/COL4A2, a major BM component, cause eye, kidney and cerebrovascular disease, including stroke. Common variants in these genes are risk factors for intracerebral hemorrhage in the general population. However, the contribution of the matrix to the disease mechanism(s) and its effects on the biology of cells harboring a collagen IV mutation remain poorly understood. To shed light on this, we engineered controlled microenvironments using polymer biointerfaces coated with ECM proteins laminin or fibronectin (FN), to investigate the cellular phenotype of primary fibroblasts harboring a COL4A2+/G702D mutation. FN nanonetworks assembled on poly(ethyl acrylate) (PEA) induced increased deposition and assembly of collagen IV in COL4A2+/G702D cells, which was associated with reduced ER size and enhanced levels of protein chaperones such as BIP, suggesting increased protein folding capacity of cells. FN nanonetworks on PEA also partially rescued the reduced stiffness of the deposited matrix and cells, and enhanced cell adhesion through β1-mediated signaling and actin-myosin contractility, effectively rescuing some of the cellular phenotypes associated with COL4A1/4A2 mutations. Collectively, these results suggest that biomaterials are able to shape the matrix and cellular phenotype of the COL4A2+/G702D mutation in patient-derived cells.
Funding tourism promotion and disaster management through hometown tax donation program

Since its start in 2008, Furusato Nozei Seido, or hometown tax donation program, has expanded its size. Many existing papers focus on the program’s history, mechanism and “unhealthy” competitions among local governments. Little attention has been given to how the donations are used. In this study, the data for the program in 2018 were used to calculate policy project priority scores of local governments in allocating newly funded money. The results showed that the most prioritized project was child care, followed by education. Tourism was in the fourth place. The priority scores were also used to calculate correlations with official tourism and natural disaster data. The tourism scores and tourism data showed weak negative correlations, suggesting that local governments with lesser tourists used the fund from the program to promote tourism. The resilience scores and disaster damage data showed positive moderate correlations, suggesting that local governments with large damage utilized the fund from the program for recovery and future prevention of the disaster. Hometown tax donation program is a part of regional revitalization strategy, which set job creation as one of the most important objectives. The local governments are advised to use the fund more on tourism, one of the most promising growing industries.
Socioeconomic Status and Nutrition of Childhood Obesity and Hypertension among Primary School Children

Özet GİRİŞ ve AMAÇ: Çocukluk çağında giderek artan sıklıklıkta görülen obezite büyük halk sağlığı problemi haline gelmiştir. Bu çalışmada, Ankara ilinde yüksek, orta ve düşük sosyoekonomik düzeyli üç ilköğretim okulunda eğitim gören çocuklarda obezite prevelansı ve obezite gelişiminde rol oynayan risk faktörlerinin belirlenmesi amaçlanmıştır. YÖNTEM ve GEREÇLER: Çalışmamızda gruplar yüksek (Grup I), orta (Grup II), düşük (Grup III) olmak üzere üç sosyoekonomik seviyeden oluşmaktadır. Aileye içinde anne-baba boy ve kiloları, beslenme alışkanlıkları, boş zamanlarında en çok ne yaptığı, okula giderken yürüyüp yürümediği, annenin ve babanın eğitim seviyesi hakkında sorular içeren bir anket gönderildi ve yazılı izinler alındı. BULGULAR: Çalışmamıza üç grupta toplam 6815 (E/K 3529/ 3286) öğrenci katılmıştır. Grup I deki obezite prevelansı, Grup II’den ve Grup III’den daha fazla bulunmuş; fakat sadece Grup I ve Grup III arasındaki fark istatiksel olarak anlamlı bulunmuştur. Anne ve babanın eğitim ve ekonomik düzeyi üniversite mezunları olanlar karşılaştırıldığında Grup I’de, Grup II ve Grup III’den anlamlı yüksek bulunmuştur. Gruplara göre öğrencilerin düzenli ve ara öğün yeme alışkanlıkları karşılaştırıldığında her üç grup arasında istatiksel anlamlı fark saptanmamıştır. TARTIŞMA ve SONUÇ: Önemli bir morbidite nedeni olan obezitenin uzun dönem olumsuz sonuçlarını önlemeye yönelik girişimler okul öncesi dönemden başlamalıdır. Obezite küresel bir sorun olmakla birlikte, obezite sıklığı sosyoekonomik düzeyi yüksek kesimlerde artmaktadır. Abstract INTRODUCTION: The increasing prevalance of obesity is a major public health problem in both the developed and the developing world. Our study is designed to estimate the prevalance of obesity and related risk factors for the primary school children of higher, medium and lower socioeconomic status in Ankara. METHODS: In our study groups are included higher (group I), medium (group II), and lower (group III) socioeconomic level. A questionnaire was applied to students’ parents including questions about parent’s weight and height, eating habits, parent’s education, sociaeconomic level and the physical activity routine. RESULTS: Totally 6815 students (M/F: 3529/ 3286) were included in the analysis, in three groups. The prevalance of obesity in group I was more than group II and group III, but only difference between Group I and Group III was statistically significant. Compared to average incomes of the family's economic level Group I was significant from Group II and Group III. Compared to regular snacks and eating habits of the students into groups there were no statistically significant differences between the three groups. DISCUSSION AND CONCLUSION: Obesity and prevention of long-term negative consequences of obesity must start at preschool period. As obesity is the global problem, obesity prevalence is increasing in children with high socio-economic levels.
Moderating effects of appreciation on relationships between illegitimate tasks and intrinsic motivation: a two-wave shortitudinal study

ABSTRACT This study investigated possible reciprocal relationships between illegitimate tasks and intrinsic motivation and whether appreciation moderated these relationships. Based on a two-wave panel study across one week and a sample of 366 nurses, we examined whether appreciation buffered effects of illegitimate tasks on reduced intrinsic motivation; or enhanced reversed effects of intrinsic motivation on decreased perceived illegitimate tasks. Additionally, we differentiated whether illegitimate tasks and appreciation were elicited by supervisors, colleagues, or patients. Latent structural equation analyses primarily revealed effects for unnecessary than for unreasonable tasks. Such tasks were predominantly the consequence rather than the cause of intrinsic motivation, and intrinsic motivation increased perceived illegitimate tasks under conditions of low appreciation. Regarding the different sources, most effects were present for illegitimate tasks ascribed by supervisors and for appreciation conveyed by patients. It follows that the perception of illegitimate tasks seems to be a matter of motivation; that the sources of illegitimate tasks and appreciation matter; and that appreciation as a low-budget, but highly powerful practice, is able to facilitate a positive environment where work tasks are less likely to be perceived as illegitimate.
Guatemala City women: empowering a vulnerable group to prevent HIV transmission.

This research project explores the behavioral and sociocultural factors that place Guatemalan women at risk for HIV infection. The project was conducted in three phases: formative research intervention design and implementation and process and outcome evaluation. For the formative research phase 20 focus group discussions were conducted with women attending a prenatal clinic male and female sexually transmitted disease (STD) clinic patients female sex workers and men and women living with HIV/AIDS. The focus group examined knowledge attitudes and sources of information about sex family planning condoms STDs and HIV/AIDS; perception of risk for HIV and STDs; sexual decision-making; and contextual factors that facilitate or hinder behavior modification. Findings indicated that women were largely at risk for contracting HIV and STDs because of their partners sexual behavior and unprotected sexual intercourse. Perception of the risk for contracting HIV infection was low among women and men because of their tendency to associate AIDS with people who lived a disordered life . Sociocultural norms that encouraged men to indulge in sex and women to be passive and uninformed about sexual matters increase womens vulnerability to contracting HIV/STDs. Moreover norms that discouraged women from being knowledgeable and communicative about sex served as barriers to partner communication a prerequisite for the adoption of HIV and STD protective behavior.
Cosmological Lithium Problem: A Sensitivity Analysis of 7Li Primordial Abundance to Dark Matter

The Cosmological Lithium Problem centers on the fact that astronomers have been unable to reconcile the abundance of lithium produced from Big-Bang Nucleosynthesis (BBN) with the actual abundances measured in very old stars. The abundance of 7Li is higher by a factor of 3 when calculated theoretically via the Standard Model compared to the abundance found in the universe. It is an unresolved issue in the BBN research. Since the observed 7Li abundance calculations have been done very accurately, and the discrepancy cannot be due to astrophysical uncertainties, it is now confirmed that the physics of the Standard Model cannot solve this discrepancy. To solve the problem, we need to look at physics Beyond the Standard Model (BSM). In this simulation, we will use sensitivity analysis to explore the impact of BSM physics on the 7Li primordial abundance. This will allow us to determine the effect of dark matter on the Cosmological Lithium Problem. The sensitivity analysis will be done using the publicly available AlterBBN simulation software. BSM approaches include variations in dark density, dark entropy, reheating, neutrino numbers, extra neutrino species, initial temperature, and mass and chemical potential of Weakly Interacting Massive Particles (WIMPs) including Majorana Fermions, Dirac Fermions, Real Scalar Bosons, and Complex Scalar Bosons. Using the BSM model, at a lower initial temperature, an increase of extra neutrino species or the combined impact of WIMPs and extra neutrino species results in a significant decrease in 7Li abundance and brings its value within 1.88 times the observed value of 1.58 ± 0.31 * 10-10. It was found that at a lower initial temperature, increasing the number of relativistic degrees of freedom (defined in terms of extra neutrino species) or its combined impact with WIMPs results in a significant decrease in the 7Li primordial abundance. But this solution to the Cosmological Lithium Problem needs further investigation from a nuclear astrophysics perspective.
A universal subcuticular bacterial symbiont of a coral predator, the crown-of-thorns starfish, in the Indo-Pacific

Background Population outbreaks of the crown-of-thorns starfish (Acanthaster planci sensu lato; COTS), a primary predator of reef-building corals in the Indo-Pacific Ocean, are major concerns in coral reef management. While biological and ecological knowledge of COTS has been accumulating since the 1960s, little is known about its associated bacteria. The aim of this study was to provide fundamental information on dominant COTS-associated bacteria through a multifaceted molecular approach. Methods A total of 205 COTS individuals from 17 locations throughout the Indo-Pacific Ocean were examined for the presence of COTS-associated bacteria. We conducted 16S rRNA metabarcoding of COTS to determine the bacterial profiles of different parts of the body, and generated a full-length 16S rRNA gene sequence from a single dominant bacterium, which we designated COTS27. We performed phylogenetic analysis to determine the taxonomy, screening of COTS27 across the Indo-Pacific, FISH to visualize it within the COTS tissues, and reconstruction of the chromosome from the hologenome sequence data. Results We discovered that a single bacterium exists at high densities in the subcuticular space in COTS forming a biofilm-like structure between the cuticle and the epidermis. COTS27 belongs to a clade that presumably represents a distinct order (so-called marine spirochetes) in the phylum Spirochaetes and is universally present in COTS throughout the Indo-Pacific Ocean. The reconstructed genome of COTS27 includes some genetic traits that are probably linked to adaptation to marine environments and evolution as an extracellular endosymbiont in subcuticular spaces. Conclusions COTS27 can be found in three allopatrically speciated COTS species, ranging from northern Red Sea to the Pacific, implying that symbiotic relationship arose before the speciation (approximately 2 million years ago). The universal association of COTS27 with COTS and nearly mono-specific association at least with the Indo-Pacific COTS potentially provides a useful model system for studying symbiont-host interactions in marine invertebrates.
Quantitative CT Imaging in Chronic Obstructive Pulmonary Disease: Review of Current Status and Future Challenges

Chronic obstructive pulmonary disease (COPD) is defined as a common preventable and treatable disease characterized by persistent airflow limitation, which is usually progressive, and is associated with enhanced chronic inflammatory responses in the airways and lung (1). COPD is a major cause of morbidity and mortality in the general population, and the WHO estimates that it will become the third leading cause of death worldwide (2). It is a heterogeneous and complex condition, with a wide variety of clinical and pathologic characteristics. Even though pulmonary function test (PFT) parameters are currently used to diagnose and classify the severity of COPD, they cannot fully represent the type and range of the heterogeneous pathophysiologic abnormalities present in COPD. Additionally, the PFT tends to be relatively insensitive to early stages and subtle changes in COPD, before functional parameters begin to show changes (3). Furthermore, patients with similar PFT values may demonstrate completely different clinical and radiological phenotypes. In the era of precision medicine, a more meticulous understanding of clinical disease manifestation and its relationship Quantitative CT Imaging in Chronic Obstructive Pulmonary Disease: Review of Current Status and Future Challenges CT를 이용한 만성폐쇄성폐질환의 정량적 평가: 현 상태와 미래 과제에 대한 리뷰
Frequency and Risk Factors of Post Banding Ulcer Bleeding Following Endoscopic Variceal Ligation in Patients with Liver Cirrhosis

Methods: One hundred and twenty six patients with liver cirrhosis subjected to EVL, whether done as prophylactic or therapeutic, were followed up for two weeks for detection of occurrence of postbanding ulcer bleeding. A prospective cohort study was performed comparing the patients that bleed after EVL due to post-banding ulcer (bleeder group, n= 10) with those without this complication (non-bleeder group, n= 116).
Educational interventions for an inclusive culture in primary school: The qualitative dimension of the PRO-SEL programme

Inclusive classrooms provide new opportunities for group membership and creation of effective learning environments. In order to facilitate the success of inclusion as an approach and philosophy, it is important that all class members as well as their teachers develop the skills to understand one another, and to communicate and work together effectively. Students with or without disabilities have the right to be educated in the least restrictive, most appropriate environment. The movement toward less restrictive environments is not only a school phenomenon; it is a societal one with the ultimate goal being to have individuals with all types of disabilities live, work and be educated in their own communities. For this reason it is imperative that the schools adjust to serve all students. If we do not work in this line, it is conceivable that he/she will not develop the necessary skills for how to effectively live and work with them. EBE-EUSMOSI have the aim to identify and integrate, within a reference model, the research procedures which can contribute to an evidence-based validation of educational programs aimed at school inclusion for all pupils. The PROSEL program was conceived: (1) From the will to experiment with innovative didactic practices which support the structure of an inclusive school through the development of social, prosocial and emotional skills in all students; (2) From the commitment to give teachers, appropriate “tools” useful in their daily work and adaptable in the increasingly heterogeneous classes. Four basic approaches to implement the PROSEL program: Systematical teaching of the social-emotional and prosocial competences; Integration of the social-emotional and prosocial competences in others subjects; Create a positive climate in class; Engaging the families.
Vzorci zasedbe prostora za potrebe sprostitve in rekreacije v obmestnem prostoru: primer Jezero pri Podpeči, Slovenija

Članek obravnava vprašanja o nosilni sposobnosti prostora za sprostitev in rekreacijo v obmestnih krajinah visokih naravnih ali kulturnih vrednot. Temelji na konceptu pristopov od spodaj navzgor, pri cemer uporablja metodo opazovanja in vedenjskih zemljevidov, ki temelji na drobnih kvalitativnih podatkih. Osredotoca se na zasnovo koncepta nosilne sposobnosti naravno vrednega obmocja za rabo in na ugotavljanje ocene nosilne sposobnosti takega obmocja za rabo. Izhajali smo iz Golicnik Marušic (2015), ki nakazuje smisel obravnave razvoja in nacrtovanja zelene infrastrukture z vidika uporabnikovih potreb in navad ter s konceptom nosilne sposobnosti prostora za zasedbo vkljucili tudi varstveni vidik. Na podlagi izvedenih podatkov, pridobljenih z opazovanjem in kartiranjem vedenja, smo komentirali dejansko rabo, uporabnike z vidika starostnih skupin ter nacin zasedanja prostora, pogostost pojavljanja dejavnosti in nacine zadrževanja v prostoru na primeru Jezera pri Podpeci, priljubljene izletniško-rekreacijske tocke na robu Ljubljanskega barja.
A novel adaptive federated filter for GNSS/INS/VO integrated navigation system

In order to solve the problem of decreased navigation performance of the Global Navigation Satellite System (GNSS)/inertial navigation system (INS) integrated navigation systems in GNSS-denied environments, and to improve the navigation accuracy and robustness of the navigation system, a novel adaptive federated filter with a feedback scheme for a GNSS/INS/visual odometry (VO) integrated navigation system is proposed in this paper. A visual-inertial odometry system model with a multi-state constraint Kalman filter structure based on a polar geometry and trifocal tensor geometry between different images is established, which can provide better navigation accuracy in GNSS-denied environments. Moreover, a new method to obtain the information allocation factor according to the different navigation performances of local filters is deduced in this paper, which has low computational complexity and a simple structure. Meanwhile, an abnormal measurement detection algorithm based on fuzzy logic is proposed to detect the abnormal measurements of local filters. The results of the vehicle experiment with the publicly available real-world KITTI dataset show that the proposed algorithm can obtain reliable navigation results in GNSS-denied environments and improve the navigation accuracy and robustness of the GNSS/INS/VO integrated navigation system.
Role of 5-hydroxytryptamine receptor 2A gene in eating disorders

Aneroxia Nervosa (AN) and Blumia Nervosa (BN) are eating disorders with complex structures. These disorders, which have strong evidence of genetic linkage, are often accompanied by anxiety disorder, mood disorder, obsessive compulsive disorder and perfectionism. Recent studies are investigating the biological origins of these disorders rather than the familial inheritance. Eating disorders and anxiety disorders have several characteristics in common. In family and twin studies indicates that 5-Hydroxytryptamine (5-HT2A) Receptor 2A have an important role in AN and BN pathogenesis. Future studies in this field will indicate the importance of the serotonergic system and its biological markers in the treatment of these nutritional disorders. Predisposition and farmacogenetic studies with larger sample groups will produce the importance of gen in nutritional disorders with more reliable arguments and will provide important information to physicians in terms of treatment approach.
The Effect of Different ApoE Genotypes and Other Risk Factors on Obstructive Sleep Apnea Syndrome Formation

Objective: Obstructive sleep apnea syndrome (OSAS) is a disorder characterized by partial or complete narrowing of the pharyngeal airway during sleep. In this study it was aimed to investigate the relation between OSAS and different variants of the ApoE gene, and to identify other risk factors that may affect the development of the disease. Materials and Methods: Fifty-two patients with OSAS and 50 healthy volunteers were enrolled into the study. After collecting the necessary information associated with OSAS from the individuals, DNA was isolated from blood. ε2, ε3 and ε4 variants of Apolipoprotein E (ApoE) gene were investigated using real-time polymerase chain reaction. Results: When the groups were compared with each other, age, body mass index, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein, triglyceride, neck circumference, waist circumference, apnea hypopnea index, Epworth sleepiness scale, smoking, and daytime sleepiness were found statistically significant. The ε2 variant was found statistically high in the control group. Also, waist circumference, triglyceride and LDL levels were found statistically low in individuals with the ε2 genotype. In addition, triglyceride levels were found statistically high in individuals with the ε4 genotype. Conclusion: The presence of the ε2 variant in healthy individuals may have a protective effect against OSAS. In addition, the relation between different variants of ApoE with LDL and triglyceride levels demonstrates the overlap of genotype and phenotype data.
Effect of Age and Socio Economic Status on the Quality of Life of Patients with Cervical Cancer Undertaking Chemotherapy at Dr. Moewardi Hospital Surakarta

Background: Cervical cancer is a type of cancer affecting women with high incidence and mortality in the world. Patient with cervical cancer have to undertake prolonged sequential treatment and therefore may experience physical, physicological and social changes, which may affect their quality of life. This study aimed to examine effect of age and socio economic status on the quality of life of patients with cervical cancer undertaking chemotherapy at Dr. Moewardi hospital Surakarta. Subjects and Method: This was an analytic observational study with cross-sectional design. This study was conducted at Dr. Moewardi Hospital, Surakarta, from February to March 2017. A sample of 100 patients was selected by fixed disease sampling. The dependent variable was quality of life. The independent variables were age, education and family income. The data were collected by questionnaire and medical record, and then were analyzed by linear regression model. Results: Education ≥ Senior High School (b= 10.25; 95% CI=5.24 to 15.26; p<0.001) and family income ≥ Minimum Regional Wage (b= 0.47; 95% CI=0.12 to 0.83; p=0.009) increased quality of life in patients with cervical cancer. Age ≥ 45 years (b=-0.53; 95% CI=-0.84 to -0.21; p=0.001) decreased quality of life in patients with cervical cancer. Conclusion: The quality of life of patient with cervical cancer is determine by age, education, and family income. Keywords: age, social economic status, quality of life, cervical cancer, chemotherapy