Miracle-dz/UniFAR-FTUs huggingface dataset:
SOUND LEVEL IN A TEN YEAR PERIOD IN SHAHREKORD CITY

چکیده: زمینه و هدف: صوت یا صدا، بخشی از زندگی روزمره بوده و برای انجام وظائف طبیعی بدن انسان ضروریست. صدا نیز همانند کلیه آلاینده ها، کیفیت زندگی را کاهش داده و باعث مخاطرات بهداشتی قابل توجهی می شود. این مطالعه با هدف بدست آوردن اطلاعات زمینه در رابطه با وضعیت سرو صدا در محیط شهری و تعیین تغییرات در تراز بندی صدا نسبت به زمان و تعیین اثر اصلاح الگوی شهرسازی در میزان آلودگی صوتی به‌ منظور بکارگیری اقدامات عملی برای محدودسازی و کنترل میزان مواجهه با صدای محیط انجام شد. روش بررسی: این تحقیق که از نوع قبل و بعد می باشد در دو مقطع زمانی (اول در سال 1372 و دوم 1381) انجام گرفت. به منظور تراز بندی صدا در سطح شهر، بر اساس مناطق متنوع و پر ترافیک، متوسط و آرام، مسکونی، آموزشی و درمانی در مقطع اول 8 ایستگاه اندازه گیری و مقطع دوم 10 ایستگاه اندازه گیری در نقاط مختلف تعیین گردید. بمنظور تعیین ردیف صدا در میان مشکلات زیست محیطی بر اساس عقیده عمومی، بصورت تصادفی 20 نفر در هر ایستگاه (شامل عابرین و ساکنین در محل) انتخاب و از آنها نظر خواهی شد و داده ها با استفاده از آزمون های آماری ویلکاکسون، کای دو و دو جمله ای تجزیه و تحلیل گردید. یافته ها: متوسط سطح صدا در روز برای مقطع اول و دوم به ترتیب 3/6±8/68 و 7/7±8/73 دسی بل (05/0p
PROTÉGÉ PREDICTORS OF SUCCESSFUL MENTORING: A REVIEW OF CURRENT RESEARCH OUTCOMES OF MENTORING

Mentoring is one of the most researched topics today. The paper tries to trace the evolution of the concept and history of mentoring. The paper mentions the theories of mentoring and the dimensions of mentoring. This is a conceptual paper, which underlines the importance of protege predictors in the success of the mentoring program. This helps the organization to plan the mentoring programs in a manner so as to increase the efficacy of the program.
The Effect of a Knee Brace on Gait Parameters of Hypertonic Hemiplegic Patients

The aim of this study was to investigate the effects of the useof a knee brace on 15 subjects with hypertonic hemiparesis. The middlecerebral artery was involved in all subjects. The Ashworth scale was usedto screen for the presence of spasticity in the quadriceps muscles.Measurements of gait speed, step and stride length were taken in the middle 10 metres of a 15 metre paper walkway. A comparison of these gait parameters without and with the use of a knee brace was made. A ques-tionnaire was also used to evaluate how subjects responded to the use of aknee brace.The results showed that the mean speed for all 15 subjects increased withthe use of a brace, (p = 0.05). Step and stride length without and with the use of a brace showed no statistical differences.It was therefore concluded that the FECK brace appears to have an effect on the walking speed of subjects withhypertonic hemiparesis
Introductory Practice Experience: An Opportunity For Early Professionalization

The development, implementation, and associated outcomes of a 30-week introductory practice course sequence in an experiential pharmacy education program is discussed. The American Council on Pharmaceutical Education accreditation standards require entry-level PharmD curricula to include both introductory and advanced practice experiences for students. Developing a curriculum at a new college of pharmacy provided opportunity to offer a course sequence focused on early rotation experiences based upon practice philosophies rather than technical/task based activities. The course sequence has been offered since 1998 and provides first professional year students an opportunity to experience pharmacy practice activities which focus on observation and provide learning through discovery and introspection. On-campus activities include presentations, panel discussions, self-directed learning, and use of guest speakers. A majority of the students surveyed increased their interest in pharmacy as a career based on experiences gained from this course sequence. Preceptors found the program equally rewarding and valuable through discussion with students concerning the issues and philosophy of pharmacy practice. Based on this data it appears the course has been successful in exposing students to early professional practice philosophies, assisting in career path evaluation, and reinforcing didactic learning through demonstration of practice situations.
Welchen Stellenwert haben Insulinanaloga in der Behandlung des Diabetes?

Der Anteil der verordneten Insulinanaloga hat sich in den letzten zehn Jahren mehr als verdoppelt und ist auf einen Anteil von 69% am Volumen aller Insulinverordnungen gestiegen. Die Frage stellt sich, ob es gute Argumente für ein solches Verordnungsverhalten gibt. Recherche in Medline und Cochrane zu Insulinanaloga. Kurz wirkende Analoga haben einen schnelleren Wirkbeginn und wirken meist kürzer als Normalinsulin. Die Wirkung lang wirkender Analoga hält länger an als die eines NPH-Insulins. Belege für einen Nutzen von Insulinanaloga hinsichtlich klinisch relevanter Endpunkte gibt es nicht. Auch hinsichtlich intermediärer Endpunkte konnte kein Vorteil belegt werden. Für Normalinsulin ist ein Spritz-Ess-Abstand nicht erforderlich. Die Reduktion nächtlicher Hypoglykämien um knapp 20% (relative Reduktion) ist bei Normalinsulin nur dann relevant, wenn zu niedrige HbA1c-Ziele verfolgt werden. Schwere Hypoglykämien sind gleich häufig. Bis auf wenige spezielle Gruppen von Personen mit Typ-1-Diabetes haben Insulinanaloga kaum einen Stellenwert, ihre Verordnung ist in den meisten Fällen unwirtschaftlich.
Resistance to selective serotonin reuptake inhibitors: role of serotonergic mechanisms

SSRIs are the mainstay in the treatment of depression. However, approximately 30% of depressed patients do not respond to antidepressants and the causes of resistance to these drugs are largely unknown. Thus, it is necessary to develop experimental models to investigate the neurobiological changes underlying the response to SSRIs. The approach used in this project was the inter-strain comparison of mice, such as DBA/2 and C57BL/6, differing in serotonin (5-HT) synthesis, due to a spontaneous mutation of tryptophan hydroxylase-2, the rate-limiting enzyme in brain 5-HT synthesis. The genotype-dependent deficit of 5-HT was associated with no response to acute and chronic citalopram and paroxetine in the forced swimming test (FST), an experimental procedure to assess the antidepressant potential of drugs, and with lower basal and citalopram-induced rise of extracellular 5-HT. The administration of the 5-HT precursor, tryptophan, or the blockade 5-HT1A autoreceptors and 5-HT2C receptor-mediated inhibitory feedback reinstated the antidepressant-like effect of citalopram. These findings suggest that boosting 5-HT neurotransmission might be a useful strategy to restore the antidepressant effect in treatment-resistant depressed patients. Further studies suggested that GABAergic inhibition is involved in the mechanism by which 5-HT2C receptor inactivation augments the effects of SSRIs whereas the ability of tryptophan to restore the antidepressant-like effect of SSRIs may involve non-serotonergic mechanisms. Finally, chronic citalopram induced opposite changes in brain-derived neurotrophic factor (BDNF), a neurotrophin linked to the long-term action of antidepressants, in the nucleus accumbens of DBA/2 and C57BL/6 mice. This suggests a possible role of this protein in the lack of response to SSRIs. Overall, these studies provide new insight into the role of 5-HT and BDNF in the response to antidepressant drugs and remark on the inter-strain comparison of mice with a spontaneous tryptophan hydroxylase-2 mutation as a useful tool for understanding the mechanism underlying the response to SSRIs and testing new potential therapeutic strategies.
ELECTROMYOGRAPHIC ACTIVITY OF THE VASTUS MEDIALIS OBLIQUE AND VASTUS LATERALIS LONGUS MM. DURING OPEN AND CLOSED KINETIC CHAIN EXERCISES

OBJECTIVES: The purpose of this study was to analyze the electromyographic activity of the Vastus Medialis Oblique (VMO) and Vastus Lateralis Longus (VLL) muscles during knee extension in Open Kinetic Chain Exercise, using a ‘knee extension table’, and in Closed Kinetic Chain Exercise, using a Horizontal Leg-Press (VITALLY). METHODS: The electromyographic activity of the VMO and VLL muscles was measured in 12 subjects between 18 and 23 years old (x=21.9 e SD=1.16), without prior hip, knee, and ankle pathologies, during Maximal Isometric Contraction (MCI) at 90o flexion of hip and knee. A 16-Channel EMG System (CAD 12/36 - 60 K - LINX) and differential surface electrodes (DELSYS) were used to obtain the data. The signal was recorded in Root Mean Square (RMS) and expressed in microvolts. The data analysis was performed through Student’s t-test at a 5% level of significance. RESULTS: The results showed that the electromyographic activity of the VMO muscle was significantly greater than that of the VLL muscle during Open and Closed Kinetic Chain Exercises. CONCLUSIONS: The data of this study, within the experimental conditions used, suggest that the VMO muscle can recover functionally by MCI at 90o flexion of hip and knee during Open Kinetic Chain Exercise, using an ‘extension table’, and also in Closed Kinetic Chain Exercise, using a Horizontal Leg-Press. This research was conducted in accordance with the National Council of Health (Resolution 196/96).
Effects of the Implementation of Reflexive Urine Cultures on Antibiotic Utilization in Hospitalized Patients

Primary Endpoints ♦ Numbers of Ucx collected and results preand post-intervention ♦ Duration of continuous antibiotic (abx) therapy from time of UA +/Ucx in hospitalized inpatients up to 7 days ♦ Total days of abx from time of UA +/Ucx in hospitalized inpatients up to 7 days Secondary Endpoints ♦ UTI diagnoses, C diff toxin assay + Experimental Design Retrospective, observational, single-center study ♦ Analysis period: Pre-intervention, February 2013-July 2013. Postintervention, September 2013-February 2014. ♦ Data obtained from UCM Clinical Research Data Warehouse Inclusion criteria ♦ Pre-intervention: all Ucx sent, ED or hospitalized ♦ Post-intervention: UA with reflex Ucx, or Ucx exemption (Fig 1) Statistical analysis ♦ Primary and Secondary outcomes: Descriptive statistics  The implementation of reflexive Ucx based on presence of pyuria on UA resulted in less Ucx being performed.  Reflexive Ucx use did not result in a decrease in overall mean total antibiotic days in hospitalized inpatients or in the subset of midstream collection within 7 days of test.  However, evaluating for mean continuous antibiotic duration after Ucx alone, there was a significant decrease in duration of therapy, both in all inpatients and in those whose samples were collected by midstream catch.  Overall CA-UTI rates decreased during this time period, and this intervention was part of a bundle of interventions aimed at decreasing CA-UTI rates.  There was not a significant decrease in C. diff diagnoses.  The reflexive Ucx policy at UCM did result in a statistically significant decrease in continuous antibiotic duration, but this is not likely clinically significant given that both durations are less than one day.
HEMODYNAMIC PARAMETERS OF PATIENTS WITH TREATED HYPERTENSION AND CORONARY ARTERY DISEASE

of Dissertation Presented to the Graduate School of the University of Florida in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy HEMODYNAMIC PARAMETERS OF PATIENTS WITH TREATED HYPERTENSION AND CORONARY ARTERY DISEASE By Patrick Heyman May 2003 Chair: Carolyn B. Yucha Major Department: College of Nursing Central elastic arteries are very different from the more peripheral muscular arteries. It has long been argued that the research and management of hypertension should not be based on blood pressures (BP) measured in the brachial artery (a muscular artery). Moreover, BP is a dynamic physiologic function that changes with the demands placed on the body and mind throughout the day. It has been argued that ambulatory BP (average of multiple BP readings over the course of a given period—usually 24 hours) is a better assessment of true BP than traditional clinic BPs. The purpose of this study is to demonstrate the differences, if any, among BPs measured by conventional methods, ambulatory BP, and aortic blood measured noninvasively by applanation tonometry and a generalized transfer function. BP measurements using all three techniques were taken on 30 subjects from the INternational VErapamil/TRandolapril STudy (INVEST). There is a highly linear relationship between central and clinic BPs in regards to systolic BP, diastolic BP, mean arterial BP, and pulse pressure (PP). Systolic BP and PP
Simultaneous transcatheter intervention for atrial septal defect complicated with patent ductus arteriosus: A 13-year single institutional retrospective study

Purpose: The feasibility and validity of simultaneous transcatheter interventions for patients with atrial septal defect (ASD) complicated with patent ductus arteriosus (PDA) has not been systematically evaluated. Materials and Methods: A retrospective analysis was conducted in patients who received transcatheter procedures for ASD complicated with PDA concurrently. The indications and treatment protocols were in accordance with the current guidelines. The sequence of therapy for ASD complicated with PDA was determined by clinical experience. Patients were followed up for at least 6 months after therapy Results: Overall, 22 patients received simultaneous transcatheter interventional therapy, and the success rate was a 100%. No severe complications transpired during the procedure or follow-up stage. Conclusion: Simultaneous transcatheter intervention is feasible and effective for patients who have concurrent complications for both ASD and PDA.
Aortic valve repair in type A aortic dissection

The role of valve sparing operations in patients with the acute type A aortic dissection (AAAD), is still matter of debate. Many different factors should be evaluated on root management in AAAD including clinical status, aortic anatomy and expertise of the centre. In this review article we sought to analyse and report the experience and results of current available series on aortic valve and root repair in AAAD. Early and long-term data will be reported and discussed in terms of survival and aortic valve function.
Associated Factors to the satisfaction degree of the user of the external gastroenterology clinic of the Central Hospital of the Peruvian Air Force. May, 2014

An observational, descriptive and cross-sectional study was performed to determine the factors associated with the degree of user satisfaction at the outpatient Gastroenterology Service in the Air Force ́s Central Hospital from Peru, because the patient’s insatisfaction is associated to Angello Rafael La Torre Mantilla, Alfredo Enrique Oyola García, Melisa Pamela Quispe Ilanzo. | Revista Gerencia y Políticas de Salud | V. 17 | No. 34 | January-June | 2018 | 2 the level of professional excellence, the efficient use of resources and very low risk for the patient. The sample consisted of 221 patients. It was found that 21.3% patients were satisfied with the care provided, 26.7% in the reliability component, 31.2% in the liability component, 48% in the security component, 38.9% in the empathy component and 32.6% in the tangible component. Insatisfaction was observed in 75 (70.8%) of males, 99 (86.1%) of females (p = 0.005), 65 (70.7%) of direct beneficiaries and 109 (84.5%) of the family members (p = 0.013). Also, as the waiting time for care increased patient ́s satisfaction decreased (r = -0.316, p = 0.000).
Status of marginal periodontal tissues in patients after myocardial infarction in Poland

Introduction. Periodontitis is associated with numerous risk factors. Many studies have proven the existing relationship between periodontitis and cardiovascular diseases. Aim. The aim of the study was to assess the state of periodontium in patients after myocardial infarction (MI), as compared to the general population. Material and methods. The study group consisted of 152 patients after MI. The control group consisted of 160 individuals. Periodontal status was assessed using the classification by Page and Eke. The interview included: gender, age, education, income level and tobacco smoking. Results. In the study group, periodontitis occurred more frequently than in the control group (84.1 vs 73.1%), including advanced periodontitis (49.7 vs 27.5%) and edentulism (11.3 vs 2.5%). In the study group, correlation was observed between prevalence of periodontitis and gender as well as age. Conclusions. The periodontal status of patients after MI is clearly worse than that of the general population and not really well-correlated with risk factors. Key words
Risk coronary factors in patients with aortic prosthetic during cardiac rehabilitation

Background: an intervention study was performed in all patients that were submitted to aortic prosthetic valve replacement surgery that began rehabilitation Revista Cubana de Medicina. 2013;52(2):99-108 http://scielo.sld. cu 100 at the Cardiac Rehabilitation Unit Department of "Hermanos Ameijeiras" Hospital during the year 2011. Objective: to characterize the behavior of coronary risk factors. Methods: the sample was comprised of 16 patients. It was observed that the most frequent age rank was 55-64 years and most of the patients were male and white. All patients received mechanical aortic valve replacement. An improvement in the functional capacity in patients after cardiac rehabilitation was observed. Sedentary life, obesity and smoking habit were cut down and there was an increase in the number of controlled diabetic and hypertensive patients. Complications did not occur in the majority of patients during rehabilitation. Conclusions: cardiac rehabilitation diminished FRC associated to a low rate of complications.
Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship.

Timothy H. Dellit, Robert C. Owens, John E. McGowan, Jr., Dale N. Gerding, Robert A. Weinstein, John P. Burke, W. Charles Huskins, David L. Paterson, Neil O. Fishman, Christopher F. Carpenter, P. J. Brennan, Marianne Billeter, and Thomas M. Hooton Harborview Medical Center and the University of Washington, Seattle; Maine Medical Center, Portland; Emory University, Atlanta, Georgia; Hines Veterans Affairs Hospital and Loyola University Stritch School of Medicine, Hines, and Stroger (Cook County) Hospital and Rush University Medical Center, Chicago, Illinois; University of Utah, Salt Lake City; Mayo Clinic College of Medicine, Rochester, Minnesota; University of Pittsburgh Medical Center, Pittsburgh, and University of Pennsylvania, Philadelphia, Pennsylvania; William Beaumont Hospital, Royal Oak, Michigan; Ochsner Health System, New Orleans, Louisiana; and University of Miami, Miami, Florida
Designing General Anesthetics That Have a Better Safety Profile

General anesthetics constitute some of the most important and widely-used therapeutic drugs in the pharmacotherapeutic armamentarium. They are routinely used effectively and with adequate precaution-safety throughout the world for a multitude of clinical applications, predominantly as adjunctive agents for surgical procedures. Nevertheless, they have potential adverse effects (such as a drop in blood pressure and the inhibition of steroid production), particularly in vulnerable populations such as the very young and the frail elderly. It would be desirable therefore to have alternative agents that are just as efficacious, but have a better safety profile in a broader spectrum of patients. Toward this end, an anesthetic based on a unique chemical core (viz., an N-arylpyrrole derivative) has been reported in preclinical models to produce anesthetic effects without hemodynamic suppression. This lead could pave the way for new general anesthetics that are safer and easier to use.
A novel truncating variant in the LAMP2 gene in a young woman with hypertrophic cardiomyopathy and variable clinical course in the family

Danon disease is a rare X-linked dominant disorder caused by mutations in the lysosome-associated membrane protein 2 gene ( LAMP2 ) [1, 2]. Reports on the phenotype of Danon disease are largely focused on severe phenotype of young male patients, who present with the classi-cal triad of massive left ventricular hypertrophy
Fatal cases of pandemic (H1N1) 2009 influenza despite their early antiviral treatment in Japan.

Figure 1. Duration between onset of illness and initiation of antiviral drugs. Both fatal and severe cases were confirmed as pandemic (H1N1) 2009 influenza by use of real-time reverse-transcription polymerase chain reaction. We included 158 fatal cases in patients who received antiviral treatment among all 198 fatal cases that were reported from 15 August 2009 (when the first case was reported) through 15 March 2010. We also included 42 severe cases in patients who received antiviral treatment among all 56 severe cases that were reported from 5 August through 11 October 2009, because the Ministry of Health, Labour, and Welfare stopped reporting severe cases in midOctober. lesterol in adults. Circulation 2002; 106:3143– 3421.
Pathophysiologie und aktuelle Behandlungskonzepte bei ausgewählten Osteonekrosen

Zusammenfassung Osteonekrosen treten sowohl beim heranwachsenden als auch ausgewachsenem Skelett meist an prädisponierenden Lokalisationen mit Bevorzugung der Epiphysen auf. Pathophysiologisch unterscheidet man neben einer idiopathischen Form zwischen einer primär vaskulären (Thromboembolien, Hämoglobinopathien usw.) und einer toxischen (Cortison, Alkohol, Chemotherapeutika usw.) Genese. Unabhängig der Ätiologie resultiert eine Nekrose der Knochentrabekel und des angrenzenden Knochenmarks sowie eine Ödembildung. Durch avaskuläre Umbauvorgänge bildet sich eine Fibrose und mechanisch instabiler Geflechtknochen aus, sodass es im Verlauf zu einer subchrondralen Fraktur und einem Gelenkkollaps kommt. Insbesondere bei Beteiligung großer Gelenke resultieren sekundär arthrotische Deformitäten, sodass insbesondere die Hüftkopfnekrose sowie die fokale subchondrale Osteonekrose und Osteochondrosis dissecans des Knies von klinischer Bedeutung sind. Diagnostisch ist neben der nativ-radiologischen Röntgendiagnostik die Magnetresonanztomographie mit der charakteristischen Darstellung des „Sichelzeichens“ entscheidend. Therapeutisch können als konservative Maßnahmen lediglich periphere Vasodilatatoren oder Bisphosphonate als off-label use Schmerzen reduzieren und die Zeit bis zum Gelenkflächenkollaps verhindern, wohingegen die hyperbare Sauerstofftherapie, die Stoßwellentherapie, Antikoagulanzien und Statine allgemein nicht angewendet werden sollten. Die Standardtherapie in frühen Stadien ist die retrograde Anbohrung mit der Zielsetzung einer Ödementlastung und einer Unterbrechung der Sklerosezone zur Revaskularisation. Weitere operative Maßnahmen wie Umstellungsosteotomien, vaskularisierte Knochentransplantate sowie Knorpelplastiken sind möglich, wobei diese mit dem prothetischem Gelenkersatz konkurrieren.