Miracle-dz/UniFAR-FTUs huggingface dataset:
The ‘political’ roles of the European Commission

ABSTRACT The extent to which the European Commission exercises ‘political’ roles in European integration is very much up for debate. Some recent analyses of the Commission take it for granted that its political roles have been in decline, while others have suggested they have increased – especially under the current President of the Commission, Jean-Claude Juncker, who was appointed in 2014 by a much more politicised process than had been used previously and whose College has sought to present itself as being guided by a political mission and as offering political leadership to the EU. In this article, we aim to show that in the debate about the political roles of the Commission, ‘political’ has often been poorly defined and operationalised. By drawing on Public Administration scholarship, we offer a framework for analysing how and where in the EU system the Commission’s political roles might become manifest. We then assess empirically these roles in different functions the Commission undertakes.
Basic fibroblast growth factor accelerates and improves second‐degree burn wound healing

Second‐degree burns are sometimes a concern for shortening patient suffering time as well as the therapeutic choice. Thus, adult second‐degree burn patients (average 57.8 ± 13.9 years old), mainly with deep dermal burns, were included. Patients receiving topical basic fibroblast growth factor (bFGF) or no bFGF were compared for clinical scar extent, passive scar hardness and elasticity using a Cutometer, direct scar hardness using a durometer, and moisture analysis of the stratum corneum at 1 year after complete wound healing. There was significantly faster wound healing with bFGF, as early as 2.2 ± 0.9 days from the burn injury, compared with non‐bFGF use (12.0 ± 2.2 vs. 15.0 ± 2.7 days, p<0.01). Clinical evaluation of Vancouver scale scores showed significant differences between bFGF‐treated and non‐bFGF–treated scars (p<0.01). Both maximal scar extension and the ratio of scar retraction to maximal scar extension, elasticity, by Cutometer were significantly greater in bFGF‐treated scars than non‐bFGF–treated scars (0.23 ± 0.10 vs. 0.14 ± 0.06 mm, 0.59 ± 0.20 vs. 0.49 ± 0.15 mm: scar extension, scar elasticity, bFGF vs. non‐bFGF, p<0.01). The durometer reading was significantly lower in bFGF‐treated scars than in non‐bFGF–treated scars (16.2 ± 3.8 vs. 29.3 ± 5.1, p<0.01). Transepidermal water loss, water content, and corneal thickness were significantly less in bFGF‐treated than in non‐bFGF–treated scars (p<0.01).
Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major

To examine the relationship between hepatic iron stores and plasma ferritin concentration in individuals treated with red cell transfusion and iron chelation therapy, 37 patients with sickle cell anemia and 74 patients with thalassemia major were studied. In each patient, hepatic iron stores were measured by an independently validated noninvasive magnetic method, and plasma ferritin was determined by immunoassay. The correlation between hepatic iron and plasma ferritin was significant both in patients with sickle cell anemia (R = 0.75, P < 0.0001) and in those with thalassemia major (R = 0.76, P < 0.0001). Regression analysis showed no significant difference between the two groups in the linear relationships between hepatic iron stores and plasma ferritin. Considering all 111 transfused patients as a group, the coefficient of correlation between hepatic iron stores and plasma ferritin was highly significant (R = 0.76, P < 0.0001). Regression analysis found that variation in body iron stores, as assessed by magnetic determinations of hepatic iron, accounted for only ∼57% of the variation in plasma ferritin, suggesting that the remainder was the result of other factors, such as hemolysis, ineffective erythropoiesis, ascorbate deficiency, inflammation, and liver disease. The 95% prediction intervals for hepatic iron concentration, given the plasma ferritin, were so broad as to make a single determination of plasma ferritin an unreliable predictor of body iron stores. Variability resulting from factors other than iron status limits the clinical usefulness of the plasma ferritin concentration as a predictor of body iron stores. © 1993 Wiley‐Liss, Inc.
Actin dynamics in growth cone motility and navigation

Motile growth cones lead growing axons through developing tissues to synaptic targets. These behaviors depend on the organization and dynamics of actin filaments that fill the growth cone leading margin [peripheral (P‐) domain]. Actin filament organization in growth cones is regulated by actin‐binding proteins that control all aspects of filament assembly, turnover, interactions with other filaments and cytoplasmic components, and participation in producing mechanical forces. Actin filament polymerization drives protrusion of sensory filopodia and lamellipodia, and actin filament connections to the plasma membrane link the filament network to adhesive contacts of filopodia and lamellipodia with other surfaces. These contacts stabilize protrusions and transduce mechanical forces generated by actomyosin activity into traction that pulls an elongating axon along the path toward its target. Adhesive ligands and extrinsic guidance cues bind growth cone receptors and trigger signaling activities involving Rho GTPases, kinases, phosphatases, cyclic nucleotides, and [Ca++] fluxes. These signals regulate actin‐binding proteins to locally modulate actin polymerization, interactions, and force transduction to steer the growth cone leading margin toward the sources of attractive cues and away from repellent guidance cues.
Nurse‐led clinics reduce severity of childhood atopic eczema: a review of the literature

Background The increasing prevalence and impact of atopic eczema in children in Western countries such as Australia substantiate the need to evaluate the current management of this illness. It has been well documented that the most important aspects in the management of atopic eczema are to allow adequate time for education and demonstration of treatments. However, current models of healthcare funding restrict the opportunity for patient education during medical consultation times. The contribution of nursing to patient care through nurse‐led clinics has significant potential in the management of many common chronic illnesses, although atopic eczema has received minimal attention by researchers to date.
Introduction: neighbourhood governance in context

Changes in the urban neighbourhoods in China have been profound over the last few decades. New neighbourhoods of commodity housing for the newly emerged middle class have been constructed, while old neighbourhoods built by the work units (production or administrative units of the state – danwei) have been privatized and sold to the sitting tenants. The rapidly heatingup realestate market in the last decade, and the consequent wealth effect on properties, have made homeowners more vigilant about anything that could have an impact on their stake in property. It is perhaps the economic motives in protecting this stake that underpin most of the collective actions of property owners. Yet such actions touch the nerve of local neighbourhood governments as they pose a risk to social stability, whose maintenance has become an important mission at all levels of government in China. The involvement of homeowners’ associations in such collective action has fuelled the general suspicion of the state regarding autonomous organizations and has triggered an orchestrated effort to put homeowners’ associations under state surveillance, even though the little autonomy they have enjoyed has been confined to property management issues within their residential neighbourhoods. The economic reform brought the danwei system to an end, with residential neighbourhoods formerly managed by the danwei being privatized and the social functions they shouldered being ‘socialized’ (transferred to families and the market). Yet, contrary to the expectation that the vacuum left by the retreat of the danwei would be filled by newly created selforganizing institutions (such as NGOs and homeowners’ associations), it is the local government that has ‘refashioned its act of governance’ (Zhang, 2006, p. 475). ‘The vacuum of governance has been filled up by the extension of government functions into the base level’ (Wu, 2002, p. 1090). Residents’ committees are at the centre of such missions. Hence the state has not retreated at the neighbourhood level but has instead rejuvenated and repackaged itself to take up new roles and functions. As the economy and society of China have become more diversified, so
Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans.

BACKGROUND Genetic factors may affect the susceptibility to tuberculosis, but no specific genes governing susceptibility have been identified. In mice, natural resistance to infection with some mycobacteria is influenced by the gene for natural-resistance-associated macrophage protein 1 (Nramp1), but the role of the human homologue of this gene, NRAMP1, in tuberculosis is unknown. We typed polymorphisms in NRAMP1 in a case-control study of tuberculosis in the Gambia, West Africa. METHODS Sequence-specific oligonucleotide hybridization and microsatellite analysis were used to type NRAMP1 polymorphisms in 410 adults (mean age, 34.7 years) with smear-positive pulmonary tuberculosis and 417 ethnically matched, healthy controls. Patients with human immunodeficiency virus infection were excluded. RESULTS Four NRAMP1 polymorphisms were each significantly associated with tuberculosis. Subjects who were heterozygous for two NRAMP1 polymorphisms in intron 4 and the 3' untranslated region of the gene were particularly overrepresented among those with tuberculosis, as compared with those with the most common NRAMP1 genotype (odds ratio, 4.07; 95 percent confidence interval, 1.86 to 9.12; chi-square= 14.58; P<0.001). CONCLUSIONS Genetic variation in NRAMP1 affects susceptibility to tuberculosis in West Africans.
Prostaglandins Stimulate Serotonin Acetylation in Chick Pineal Cells: Involvement of Cyclic AMP‐Dependent and Calcium/Calmodulin‐Dependent Mechanisms

Abstract: The effects of prostaglandins (PGs) on the activity of the rate‐limiting enzyme of melatonin biosynthesis, aryl‐alkylamine‐N‐acetyltransferase (NAT) were investigated on primary cultures of dispersed chick pineal cells. In indomethacin‐treated cells, PGs caused a four‐fold increase in NAT activity. This response was associated with an eightfold increase in cyclic AMP (cAMP) levels. The potency order of PGs was the same for NAT and for cAMP responses (PGE1 > PGE2 > PGF2α≫ cloprostenol). However, each PG tested was 30‐ to 200‐fold more potent to increase NAT activity than to stimulate cAMP accumulation. As a result, half‐maximal stimulation of NAT by PGs was not associated with an increase in cAMP levels. Half‐maximal stimulation of NAT by PGE1 was highly sensitive to inhibition by a calcium/calmodulin antagonist (W‐7). In contrast, maximal stimulation of NAT by PGE1 as well as stimulations evoked by either forskolin or 8‐bromo‐cAMP were poorly sensitive to inhibition by W‐7. These results indicate that an increase in cAMP levels may be responsible for the maximal stimulation of NAT evoked by PGs, whereas half‐maximal stimulation of NAT by PGs would rely principally on a calcium/calmodulin‐dependent mechanism.
First contact in verb acquisition: defining a role for syntax.

The goal of this research was to address 2 questions regarding children's use of syntactic information in acquiring verbs: First, what are children's biases for actions in the absence of syntactic information; and second, how specific is the meaning derived for verbs when syntactic information is present? In 3 experiments we presented nonsense verbs either in syntactic isolation (e.g., "Look! Sebbing! ") or embedded within a transitive syntactic frame (e.g., "The frog is sebbing the duck"). These actions were then separated, and the children (mean age = 2 years, 3 months) were asked to select the action which was the referent of the verb. In Experiment 1, Causative actions (in which 1 character forces another to move in some way) were paired with Synchronous actions (in which both characters move simultaneously). In Experiment 2, the same Synchronous actions were now paired with Contact actions (in which 1 character merely touches the other). In Experiment 3, the Contact actions were paired with Causative ones. 2 results emerged: (1) Children have identifiable action biases in the absence of syntactic information and (2) these biases can be shifted by the addition of a transitive syntactic frame. We conclude that the meaning derived from the transitive frame is not specifically Causative or Contact but, more generally, a sense that 1 character is affecting another.
Cooperative multimedia management for participative learning: A case study

Web 2.0 has definitively twisted roles and rules within processes leading to the final online resources we all can enjoy on the Internet. Producers and consumers of Web contents merged into “prosumers”, dialectically sharing their knowledge, their experiences, as well as their needs. Such novel dynamics provide a strong spin-off for e-learning methodologies and technologies, by allowing students participation along learning materials life cycle, from simple feedbacks, up to real enrichments of didactical resources. As elsewhere on the Web 2.0 scenario, inclusive aspects of e-learning 2.0 represent either a new challenge or a new opportunity. This paper presents an e-learning 2.0 tool which is able to support users during the collaborative editing of didactical contents, from simple text to compound multimedia. Starting from a resource provided by the lecturer, learners can contribute in adding alternative contents and views, creating a multidimensional information structure. The resulting enriched material can be tailored to a specific user by resorting to automatic adaptation mechanisms. By utilizing typical Web 2.0 interfaces, our system involves all the different actors (lecturers, learning technologists, student support services, staff developers and students) to play a key role in improving the accessibility and, more generally, the effectiveness of learning materials.
Hybridization of III-V semiconductor membranes onto ion-exchanged waveguides

In this paper, we present an original method for the realization of hybrid photonic integrated circuits (PICs) based on ion-exchanged (IE) waveguides and III-V semiconductor materials. In our approach, we propose to bond thin semiconductor membranes at designated locations of the PIC where active functions are required. The advantage of very thin membranes is the possibility to keep the optical pathway defined by the IE waveguides even if the semiconductor refractive index is much higher than the glass refractive index. Modal analysis and beam propagation method simulations have been carried out in order to predict the modal structure of the propagated light into the membrane loaded IE waveguide and the transition from the IE waveguide itself through adiabatic tapers.
atBRX1-1 and atBRX1-2 are involved in an alternative rRNA processing pathway in Arabidopsis thaliana

Ribosome biogenesis is an essential process in all organisms. In eukaryotes, multiple ribosome biogenesis factors (RBFs) act in the processing of ribosomal (r)RNAs, assembly of ribosomal subunits and their export to the cytoplasm. We characterized two genes in Arabidopsis thaliana coding for orthologs of yeast BRX1, a protein involved in maturation of the large ribosomal subunit. Both atBRX1 proteins, encoded by AT3G15460 and AT1G52930, respectively, are mainly localized in the nucleolus and are ubiquitously expressed throughout plant development and in various tissues. Mutant plant lines for both factors show a delay in development and pointed leaves can be observed in the brx1-2 mutant, implying a link between ribosome biogenesis and plant development. In addition, the pre-rRNA processing is affected in both mutants. Analysis of the pre-rRNA intermediates revealed that early processing steps can occur either in the 5′ external transcribed spacer (ETS) or internal transcribed spacer 1 (ITS1). Interestingly, we also find that in xrn2 mutants, early processing events can be bypassed and removal of the 5′ ETS is initiated by cleavage at the P′ processing site. While the pathways of pre-rRNA processing are comparable to those of yeast and mammalian cells, the balance between the two processing pathways is different in plants. Furthermore, plant-specific steps such as an additional processing site in the 5′ ETS, likely post-transcriptional processing of the early cleavage sites and accumulation of a 5′ extended 5.8S rRNA not observed in other eukaryotes can be detected.
Plasmid-associated bacteriocin production by a strain of Carnobacterium piscicola from meat

Carnobacterium piscicola LV17 isolated from vacuum-packed meat produces bacteriocin(s) that is active against closely related lactic acid bacteria, Enterococcus spp. , and a strain of Listeria monocytogenes but not against gram-negative bacteria. The bacteriocin has a bactericidal mode of action, is heat resistant, and is stable over a wide range of pH but is inactivated by proteolytic enzymes. Sensitive and resistant cells were shown to adsorb the bacteriocin, but cell death depended on contact of the bacteriocin with the cell membrane. Bacteriocin production is detected early in the growth cycle of the organism in APT broth, but it is not produced in APT broth adjusted to pH 5.5. Bacteriocin production and resistance to the bacteriocin produced are associated with two plasmids of 40 and 49 megadaltons. The possibility that two bacteriocins are produced is indicated because the inhibitory substances of the mutant strains containing either the 40- or 49-megadalton plasmids have different antimicrobial spectra.
Novel Eukaryotes from the Permanently Anoxic Cariaco Basin (Caribbean Sea)

ABSTRACT Present knowledge of microbial diversity is decidedly incomplete (S. J. Giovannoni and M. S. Rappé, p. 47-84, in D. Kirchman, ed., Microbial Ecology of the Oceans, 2000; E. Stackebrandt and T. M. Embley, p. 57-75, in R. R. Colwell and D. J. Grimes, ed., Nonculturable Microorganisms in the Environment, 2000). Protistan phylogenies are particularly deficient and undoubtedly exclude clades of principal ecological and evolutionary importance (S. L. Baldauf, Science 300:1703-1706, 2003). The rRNA approach has been extraordinarily successful in expanding the global prokaryotic record (S. J. Giovannoni and M. S. Rappé, p. 47-84, in D. Kirchman, ed., Microbial Ecology of the Oceans, 2000; E. Stackebrandt and T. M. Embley, p. 57-75, in R. R. Colwell and D. J. Grimes, ed., Nonculturable Microorganisms in the Environment, 2000) but has rarely been used in protistan discovery. Here we report the first application of the 18S rRNA approach to a permanently anoxic environment, the Cariaco Basin off the Venezuelan coast. On the basis of rRNA sequences, we uncovered a substantial number of novel protistan lineages. These included new clades of the highest taxonomic level unrelated to any known eukaryote as well as deep branches within established protistan groups. Three novel lineages branch at the base of the eukaryotic evolutionary tree preceding, contemporary with, or immediately following the earliest eukaryotic branches. These newly discovered protists may retain traits reminiscent of an early eukaryotic ancestor(s).
Patterns of Competition with Captive Customers

We study mixed-strategy equilibrium pricing in oligopoly settings where consumers vary in the set of suppliers they consider for their purchase---some being captive to a particular firm, some consider two particular firms, and so on. In the case of "nested reach" we find equilibria, unlike those in more standard models, in which firms are ranked in terms of the prices they might charge. We characterize equilibria in the three-firm case, and contrast them with equilibria in the parallel model with capacity constraints. A theme of the analysis is how patterns of consumer interaction with firms matter for competitive outcomes.
Image-guided 25-gauge needle biopsy for thoracic lesions: diagnostic feasibility and safety.

PURPOSE To report our experience regarding the feasibility and safety of 25-gauge needles for biopsy of thoracic lesions. MATERIALS AND METHODS Twenty-six patients with thoracic lesions, predominately pulmonary nodules, measuring 0.7-5.2 cm (mean, 1.6 cm) underwent biopsy with computed tomographic (n = 24), ultrasonographic (n = 1), or fluoroscopic (n = 1) guidance. Nineteen patients had severe chronic obstructive pulmonary disease (COPD), one had severe restrictive lung disease, and one had a coagulopathy; the other five patients had nonpulmonary primary tumors. Biopsy with an inner 25-gauge needle traversing an outer extrapleural coaxial cannula was performed in all patients. Cytologic quick staining was performed routinely to determine specimen adequacy and to establish a preliminary diagnosis. Complications, specimen adequacy, and need for larger specimens were evaluated. RESULTS Adequate specimens (as determined by cytopathologists) were obtained in 24 (92%) of 26 patients, with a definitive diagnosis achieved in 23 (88%) patients during initial quick staining (17 malignant and six benign diagnoses). Two cases initially considered suspicious for malignancy were reclassified as benign (thymoma and histoplasmosis). At the request of cytopathologists, a larger needle was used to supplement the 25-gauge needle in six patients: In one patient, it provided further diagnostic information; in four, it did not; and in one, it confirmed non-Hodgkin lymphoma. Five patients developed a small pneumothorax (<10%) with use of the 25-gauge needle alone; one other patient, in whom larger needles were placed, received a radiologic chest catheter to evacuate the pneumothorax, thereby allowing the biopsy to continue. CONCLUSION Image-guided 25-gauge needle biopsy is both feasible and safe.