Miracle-dz/UniFAR-FTUs huggingface dataset:
Applying filter approach and genetic algorithm wrapper for gene selection from gene expression data

Gene expression microarray data is expected to significantly aid in the development of efficient cancer diagnosis and classification platforms. One problem arising from this data is how to select a small subset of genes from thousands of genes and much fewer samples that are inherently noisy. This research deals with finding a small subset of informative genes from the gene expression data which maximize the classification accuracy and minimize the running time. This paper proposed a model of gene expression classification by using filter approach and an improved Genetic Algorithm wrapper approach. We show that the classification accuracy and execution time of the proposed model are useful for cancer classification of two widely used gene expression benchmark data sets.
Global robot path planning using exact variational methods

A two-dimensional robot path planning algorithm with some simplifying constraints on the robot dynamics and obstacle shapes is presented. The global path planning problem is formulated as a variational optimization problem. Normally such a formulation is intractable, since an obstacle-cluttered environment will present multiple trajectories that are locally optimal solutions. To remove the intractability and derive an algorithm that produces a unique global solution, an embedding method is used. A fictitious third dimension is added to the two-dimensional formulation; local (but nonglobal solutions) in the original problem become saddle-point trajectories in the embedded formulation, allowing for convergence of a numerical algorithm to continue along a descent path. The computational algorithm becomes globally convergent: i.e. convergence to the global solution is achieved regardless of the initial choice of a nominal solution needed to start the numerical algorithm. <<ETX>>
Evaluating Text-to-Speech Synthesizers.

Text-To-Speech (TTS) synthesizers have piqued the interest of researchers for their potential to enhance the L2 acquisition of writing (Kirstein, 2006), vocabulary and reading (Proctor, Dalton, & Grisham, 2007) and pronunciation (Cardoso, Collins, & White, 2012; Soler-Urzua, 2011). Despite their proven effectiveness, there is a need for up-to-date formal evaluations of TTS systems. The present study was an attempt to evaluate the language learning potential of an up-to-date TTS system at two levels: (1) speech quality (comprehensibility, naturalness, accuracy, and intelligibility) and (2) focus on a linguistic form (via a feature identification task). For Task 1, participants listened to and rated humanand TTS-produced stories and sentences on a 6-point scale (1); for Task 2, they listened to 16 humanand TTS-produced sentences to identify the presence of a target feature (English regular past -ed). Results of paired samples t-tests indicated that for speech quality, the human samples earned higher ratings than the TTS samples. For the second task (past -ed perception), the TTS and human-produced samples were equivalent. The discussion of the findings will highlight how TTS can be used to complement and enhance the teaching of L2 pronunciation and other linguistic skills both inside and outside the classroom.
Thrombophilie und HELLP-Syndrom in der Schwangerschaft – Fallbericht und Literaturübersicht

Zusammenfassung Thrombophilie oder Thromboseneigung kann durch genetisch bedingte Defekte wie die Faktor-V-Leiden- und die Prothrombingen-Mutation oder erworbene Störungen, z. B. östrogeninduzierte APC-Resistenz, sowie das Antiphospholipidsyndrom verursacht werden. Die Schwangerschaft greift in erheblichem Maße in das Gerinnungssystem ein, was zu einem weiteren Anstieg des bereits erhöhten Thromboserisikos von Frauen mit einer Thrombophilie in der Schwangerschaft führt. Außerdem wird auch ein Zusammenhang zwischen Thrombophilien und Schwangerschaftskomplikationen wie rezidivierenden Aborten, intrauterinem Fruchttod, Präeklampsie und HELLP-Syndrom in Erwägung gezogen 1 2. Als Ursachen für die plazentaassoziierten Schwangerschaftserkrankungen werden dabei eine gestörte Differenzierung des Trophoblasten im 1. Trimenon und eine unzureichende Dilatation der utero-plazentaren Gefäße diskutiert, die infolge einer lokalen Hämostasestörung mit gesteigerter Thrombinbildung durch einen direkten Einfluss von Thrombin auf das Trophoblastzellwachstum entstehen. Ferner können Makro- und Mikrothrombosierungen der fetalen Stammzottengefäße und Spiralarterien zur multiplen Infarktbildung mit Freisetzung von nekrotischen Trophoblastfragmenten und Produktion inflammatorischer Zytokine führen, welche in der Pathogenese von gehäuften Aborten und intrauterinem Fruchttod eine sehr wichtige Rolle spielen 2. Bei bekannter Thrombophilie wird nach individueller Risikostratifizierung entweder eine postpartale oder eine kombinierte ante- und postpartale Thromboseprophylaxe mit niedermolekularen Heparinen (NMH) empfohlen. Der Nutzen der NMH zur Vermeidung von Schwangerschafts komplikationen wird kontrovers diskutiert. Bei bestimmten Krankheitsentitäten, etwa beim Antiphospholipidsyndrom, kann eine zusätzliche Behandlung mit Acetylsalicylsäure (ASS) das Schwangerschaftsoutcome verbessern 3 4. In diesem Fallbericht werden die Schwangerschaftsverläufe bei einer 28-jährigen Frau mit heterozygoter Prothrombingenmutation und HELLP-Syndrom geschildert, die nach Spätabort und Totgeburt unter einer prophylaktischen antenatalen Antikoagulation mit NMH, kombiniert mit einer engmaschigen interdisziplinären Schwangerschaftsbetreuung, 3 gesunde Kinder zur Welt brachte.
Review of Metamodeling Techniques in Support of Engineering Design Optimization

Computation-intensive design problems are becoming increasingly common in manufacturing industries. The computation burden is often caused by expensive analysis and simulation processes in order to reach a comparable level of accuracy as physical testing data. To address such a challenge, approximation or metamodeling techniques are often used. Metamodeling techniques have been developed from many different disciplines including statistics, mathematics, computer science, and various engineering disciplines. These metamodels are initially developed as “surrogates” of the expensive simulation process in order to improve the overall computation efficiency. They are then found to be a valuable tool to support a wide scope of activities in modern engineering design, especially design optimization. This work reviews the state-of-the-art metamodel-based techniques from a practitioner’s perspective according to the role of metamodeling in supporting design optimization, including model approximation, design space exploration, problem formulation, and solving various types of optimization problems. Challenges and future development of metamodeling in support of engineering design is also analyzed and discussed.Copyright © 2006 by ASME
Proceedings of the 7th International Workshop on Middleware Tools, Services and Run-Time Support for Sensor Networks

We welcome you to the proceedings of the 7th International Workshop on Middleware Tools, Services and Run-Time Support for Sensor Networks (MidSens'12). This year's workshop builds on the success of the previous six editions in Melbourne, Newport Beach, Leuven, Urbana-Champaign and Bangalore. This year's workshop took place in Montreal, Canada on December 4th 2012.
A 1.25 Gb/s high sensitive peak detector in optical burst-mode receiver using a 0.18 /spl mu/m CMOS technology

This paper introduces a novel peak detection in the burst-mode receiver considering the extinction ratio (6dB) of the received burst packet cells. The peak detector is designed using a 0.18 /spl mu/m CMOS technology and can be applied to the optical burst-mode receiver in an Ethernet PON system. By adopting this method, we can get the -29 dBm sensitivity and -8 dBm overload at 1.25 Gb/s.
RIFL : a language with filtered iterators

RIFL is a new programming language that enables developers to write only commoncase code to robustly process structured inputs. RIFL eliminates the need to manually handle errors with a new control structure, filtered iterators. A filtered iterator treats inputs as collections of input units, iterates over the units, uses the program itself to filter out unanticipated units, and atomically updates program state for each unit. Filtered iterators can greatly simplify the development of robust programs. We formally define filtered iterators in RIFL. The semantics of filtered iterators ensure that each input unit affects program execution atomically. Our benchmarks show that using filtered iterators reduces an average of 41.7% lines of code, or 58.5% conditional clauses and 33.4% unconditional computation, from fully manual implementations. Thesis Supervisor: Martin C. Rinard Title: Professor of Computer Science
A Microcontroller Based Class-D Power Amplifier for Low Frequency Sonar Application

A processor controlled Switch Mode Power Amplifiers (SMPA) for a frequency (1kHz10kHz) to excite electro-acoustic transducers for an active sonar system is explained in this paper. The system uses a low cost digital signal controller, can precisely control various parameters of interest viz. amplitude, frequency, pulse length, pulse repetition rate. The programmability, insertion of programmable dead band and ease of implementing protection schemes make digitally controlled SMPA a attractive system. A Digital method to generate Sine Pulse Width Modulation (SPWM) signal is described. A prototype digital class D power amplifier of 1kW has been fabricated for the above frequency range. An experimental result of prototype power amplifier for a frequency range of 1 kHz10 kHz is presented at the end. Keywords— Acoustic Transducer, Switch Mode Power amplifier, Active Sonar, Micro controller, Unipolar PWM, digital, Class D.
A Sparse Component Analysis Approach to EPR Spectra Decomposition

Organic free radicals play important roles in many physiological and pathological pathways in biological systems. These radicals can be detected and quantified by their EPR spectra. The measured EPR spectra are often mixtures of pure spectra of several di fferent free radicals and other chemicals. Blind source separation can be applied to estimate the pure spectra of interested free radicals. Because the pure EPR spectra are often not independent of each other, the ICA based approach cannot accurately get the wanted spectra. In this paper we present a sparse component analysis method, which exploiting the sparsity of the EPR spectra, to reliably extract the pure source spectra from their mixtures with high accuracy. The proposed method can also be used in other similar applications, or be utilized in the sparse decomposition approach to blind source separation.
Methodology for the in vitro evaluation of the delivery efficiency from valved holding chambers with facemasks.

BACKGROUND In vitro performance studies of valved holding chamber (VHC)-facemask systems are a cost-effective means of circumventing potentially confounding clinical variables. This article reports results of an in vitro investigation into VHC-facemask performance, using three age-specific soft anatomical model (SAM) faces, under clinically relevant conditions. METHODS A potentially standardized method was developed to assess VHC-facemask seal leakage, and evaluate the in vitro delivery efficiency of conventional and antistatic VHC-facemask systems. A custom-built test rig and VHC cradles were used to position the VHC-facemask systems against the SAM faces, with a constant, reproducible force. A standardized simulated pediatric breathing pattern (tidal volume = 155 mL; inhalation:exhalation ratio = 40:60; 25 breaths/min) was utilized. Percent facemask seal leakage, percent delivered dose, and the effect of different numbers of simulated breaths (2 to 8) were investigated. RESULTS Of the VHC-facemask systems tested, the OptiChamber Diamond VHC with LiteTouch facemask (Diamond) system had the lowest percent seal leakage with each SAM face. Percent seal leakage from the other VHC-facemask systems was similar with SAM0 and SAM2 faces; the AeroChamber Plus Z-Stat VHC with ComfortSeal facemask (AC Z-Stat) system had a substantially greater percent seal leakage with the SAM1 face. Regardless of the number of simulated breaths, the Diamond system delivered the greatest mean percent delivered dose, with the lowest coefficient of variation, with each SAM face. Percent delivered dose did not correlate well with seal leakage, particularly for VHC-facemask systems with high seal leakage. The electrostatic properties of the VHCs appeared to influence drug delivery. CONCLUSIONS This study describes a potentially standardized method for the evaluation of VHC-facemask systems. Use of this method enabled a comprehensive investigation into the influence of clinically relevant variables, including age-specific facial anatomy, number of simulated breaths, and seal leakage, on the delivery efficiency of several commercially available VHC-facemask systems.
A state-variable approach to symbolic circuit simulation in the time domain

Presents a hierarchical method for performing symbolic simulation in the time domain using a state-variable approach. The authors illustrate the development of the symbolic state-variable matrices for the subcircuits of a partitioned network, and the methodology for the hierarchical analysis. The resultant state equations are combined to produce the compact state-variable equations for the entire system. This hierarchical method exhibits a large reduction in the number of operations and in the size of the characteristic matrices needed to characterize the state variable equations for the network. This enables the application of the method to large-scale networks. The method accommodates a model for ideal operational amplifiers. <<ETX>>
Making apis more usable with improved api designs, documentation and tools

An important and challenging programming activity is using application programming interfaces (APIs), frameworks, toolkits and libraries. Programmers implementing new functionality need to determine which APIs to use and how to combine them. Programmers reading or modifying code need to understand how existing code that calls APIs works, what assumptions the code makes, and how to change or add to the code without breaking these assumptions. These tasks are increasingly challenging for programmers with the growing size and complexity of APIs; the Java 1.5 JDK, for example, has more than 4,000 classes and more than 30,000 methods. API designers have a challenging task in creating and maintaining these APIs, and they must make many different API design decisions that may affect the usability of APIs in unexpected ways. This thesis presents ways to improve the usability of the APIs and programming tools programmers use by examining the decisions that API designers make and performing studies comparing design alternatives. It provides evidence that more usable APIs and tools can make programmers faster and can more closely match programmers' mental models. The studies inform recommendations and highlight usability tradeoffs that provide API designers with an empirical basis for the design of usable APIs. The studies also provide insight into how programmers work and how programming tools should be designed. I first mapped out the space of API design decisions. I examined three API design decisions relating to object creation using constructors and factories, and method placement. Based on the results of these studies, I also designed, implemented and evaluated new API documentation and programming tools.
Cache management for real time visualization of 2D data sets

We present a general cache management algorithm with data pre-loading that optimizes access to data in real-time applications. We show that our algorithm provides the optimum results when the visualization sequence is known. We also present an oracle that estimates the visualization sequence for 2D data sets, and show the results of the algorithm in a virtual panorama viewer.
Creation and validation of S. pombe gene database for GenMAPP analysis

technique is widely used to understand various aspects of cellular biology. Biologists seeking to harness the potential of this technique are challenged by complex statistical algorithms employed by commonly used analysis programs. Moreover these programs analyse and visualize data without taking into account the biological context of genes. GenMAPP (Gene Map Annotator and Pathway Profiler) is a free stand-alone computer program, designed and developed at the J. David Gladstone Institutes, San Francisco. It assists in viewing and analysing omics data in the context of biological pathways as well as the Gene Ontology (GO). This facilitates fast, easy and systematic presentation and analysis of high-throughput data. However this software requires species specific gene ontology based database for analysis. We have created and validated a custom GenMAPP gene database (a species specific library of gene information) for Schizosaccharomyces pombe in collaboration with the GenMAPP team. The necessary gene data was collected from various public resources. In addition, GenMAPP pathways for S. pombe were inferred from existing S. cerevisiae pathways using homology information. The database can be used with the GenMAPP software to understand biology of S. pombe species. We have also validated this database using available microarray data. The database can be accessed from: http://www.databases. niper.ac. in/pombe.
A Simple Fluid Model for the Analysis of the Squirrel Peer-to-Peer Caching System

Peer-to-peer (P2P) systems are complex to analyze due to their large number of users who connect intermittently and to the frequency of requests for files or Web objects. In this paper we propose a mathematical model in which request streams are represented as fluid flows and then apply this model in an analysis of Squirrel: a recent P2P cooperative Web cache. Our fluid model provides a low-complexity means to estimate the performance of Squirrel (hit probability and latency) and ex- hibits the key qualitative properties of this system. The accuracy of our model is validated by a comparison with discrete-event simulation. results and at a low numerical complexity. Content distribu- tion networks appear to be good candidates to illustrate our approach as they typically involve a large number of users and many parameters. In turn, these characteristics imply large state spaces and a high numerical complexity when one uses detailed (microscopic) models (such as the Markovian) and simulations. In Section II we provide an overview of Squirrel. Our fluid model is introduced in Section III and we use it in Section IV to compute the main performance of Squirrel (hit probability, latency, etc.). In particular, we provide a simple expression for the hit probability, whose complexity is linear in the number of nodes in the Squirrel network. We show in Section V that our model provides substantial insight into performance issues of P2P cooperative Web caches such as Squirrel. Our analysis shows that two key parameters largely determine the performance of the system. In Section VI we compare results obtained with the fluid model to results obtained with a discrete-event simulation of Squirrel. We find that the fluid model is both qualitatively and quantitatively accurate. We conclude in Section VII with possible extensions of our fluid model.
An embedded software component quality model - EQM

Component-based software development is becoming more generalized, representing a considerable efficient design for the embedded industry. The perspective of reduced development costs and shorter life cycles acts as a motivation for this expansion. However, several technical issues remain unsolved before embedded software component's industry reaches the maturity exhibited by other hardware component industries. Problems such as the component selection by their integrators and the uncertain quality of thirdparty developed components, bring new challenges to the embedded system design community. By the other hand, the embedded software components certification area is still immature and further research is needed in order to obtain well-defined standards for certification. In this way, we aim to propose an embedded component quality model, describing consistent and well-defined characteristics, quality attributes and related metrics for the components evaluation. A preliminary evaluation to analyze the results of using the embedded software component quality model proposed is also presented.
Enfermedad arterial periférica e insuficiencia renal: una asociación frecuente

Determinar la prevalencia de insuficiencia renal en poblacion mayor de 49 anos de edad con enfermedad arterial periferica y analizar su relacion con factores de riesgo y enfermedad cardiovascular. Material y metodos: Estudio epidemiologico prospectivo de 3 anos de duracion con seleccion por muestreo aleatorio simple en poblacion general de edad superior a 49 anos. Se recogieron datos demograficos, clinicos, prevalencia de factores de riesgo y enfermedad cardiovascular. Se definio enfermedad arterial periferica (EAP) por indice tobillo-brazo . 0,9 e insuficiencia renal cronica (IRC) segun valores de filtrado glomerular estimado por la formula MDRD < 60 ml/min/1,73 m2. Se presentan datos basales. Resultados: Se incluyeron 511 personas de 66,6 (9,7) anos de edad media (desviacion estandar), 37% varones. La prevalencia de EAP fue del 12,4% (n = 63) de la muestra, de 72,6 anos de edad media, 46% varones. La presencia de enfermedad renal cronica en estadios 3-5 fue del 39,7%. Los pacientes con EAP e IRC, en comparacion con los que tenian funcion renal normal, eran de mayor edad (75,6 vs. 70,6, p = 0,08), predominantemente mujeres (64 vs. 47,4%, p = no significativa [ns]), presentaban cifras mas elevadas de presion arterial sistolica y diastolica (159,2 vs. 146,1, p = ns y 85,7 vs. 80,3 mmHg, p = 0,09), proteina C reactiva (1,23 vs. 0,38 mg/dl, p = 0,05) y cociente albumina-creatinina (90,2 vs. 26,4 mg/g, p = ns). En este grupo, la prevalencia de factores de riesgo cardiovascular y enfermedad cardiovascular asociada fueron notablemente superiores, sin alcanzar significacion estadistica. Conclusiones: La insuficiencia renal esta presente en el 39,7% de los pacientes con EAP y delimita un subgrupo de pacientes con elevado riesgo cardiovascular.
Adaptive Splitting TCP for Wireless Sensor Networks

Chien-Ping Liu Department of Management Information Technology and Science Institute of Northern Taiwan Clare8628@gmail.com doi : 10.4156/ijei.vol2. issue2.9 Abstract Wireless sensor networks (WSNs) comprise spatially distributed sensor nodes to cooperatively monitor physical conditions in harsh environments that make packet transmission unreliable. Some studies try to adapt the well-known transmission control protocol (TCP) for reliable data transport in WSNs. However, a long multi-hop connection usually leads to poor performance, such as low packet delivery ratios and throughputs. The connection can be split into multiple shorter fragments by selecting some intermediate nodes as TCP proxies to improve performance. This letter proposes a scheme called adaptive split TCP (AS-TCP) which can adaptively split a TCP connection into fragments of varied lengths (i.e., numbers of hops) based on wireless channel conditions. Our simulation results show that AS-TCP outperforms related ones in terms of the packet delivery ratio, and throughput.