Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of the Gene Encoding the Chemorepellent Semaphorin III Is Induced in the Fibroblast Component of Neural Scar Tissue Formed Following Injuries of Adult But Not Neonatal CNS

This study evaluates the expression of the chemorepellent semaphorin III (D)/collapsin-1 (sema III) following lesions to the rat CNS. Scar tissue, formed after penetrating injuries to the lateral olfactory tract (LOT), cortex, perforant pathway, and spinal cord, contained numerous spindle-shaped cells expressing high levels of sema III mRNA. The properties of these cells were investigated in detail in the lesioned LOT. Most sema III mRNA-positive cells were located in the core of the scar and expressed proteins characteristic for fibroblast-like cells. Neuropilin-1, a sema III receptor, was expressed in injured neurons with projections to the lesion site, in a subpopulation of scar-associated cells and in blood vessels around the scar. In contrast to lesions made in the mature CNS, LOT transection in neonates did not induce sema III mRNA expression within cells in the lesion and was followed by vigorous axonal regeneration. The concomitant expression of sema III and its receptor neuropilin-1 in the scar suggests that sema III/neuropilin-1-mediated mechanisms are involved in CNS scar formation. The expression of the secreted chemorepellent sema III following CNS injury provides the first evidence that chemorepulsive semaphorins may contribute to the inhibitory effects exerted by scars on the outgrowth of injured CNS neurites. The vigorous regrowth of injured axons in the absence of sema III following early neonatal lesions is consistent with this notion. The inactivation of sema III in scar tissue by either antibody perturbation or by genetic or pharmacological intervention could be a powerful means to promote long-distance regeneration in the adult CNS.
Microgravity during spaceflight directly affects in vitro osteoclastogenesis and bone resorption

During space flight, severe losses of bone mass are observed. Both bone formation and resorption are probably involved, but their relative importance remains unclear. The purpose of this research is to understand the role of osteoclasts and their precursors in microgravity‐induced bone loss. Three experiments on isolated osteoclasts (OCs) and on their precursors, OSTEO, OCLAST, and PITS, were launched in the FOTON‐M3 mission. The OSTEO experiment was conducted for 10 d in microgravity within bioreactors with a perfusion system, where the differentiation of precursors, cultured on a synthetic 3‐dimensional bonelike biomaterial, skelite, toward mature OCs was assessed. In OCLAST and in PITS experiments, differentiated OCs were cultured on devitalized bovine bone slices for 4 d in microgravity. All of the experiments were replicated on ground in the same bioreactors, and OCLAST also had an inflight centrifuge as a control. Gene expression in microgravity, compared with ground controls, demonstrated a severalfold increase in genes involved in osteoclast maturation and activity. Increased bone resorption, proved by an increased amount of collagen telopeptides released VS ground and centrifuge control, was also found. These results indicate for the first time osteoclasts and their precursors as direct targets for microgravity and mechanical forces. — Tamma, R. ,Colaianni, G. , Camerino, C. , Di Benedetto, A. , Greco, G. , Strippoli, M. , Vergari, R. , Grano, A. , Mancini, L. , Mori, G. , Colucci, S. , Grano, M. , Zallone, A. Microgravity during spaceflight directly affects in vitro osteoclastogenesis and bone resorption. FASEB J. 23, 2549–2554 (2009)
Transparency, Specialization and FDI

We develop a simple information-based model of FDI flows. On the one hand, the relative abundance of "intangible" capital in specialized industries in the source countries, which presumably generates expertise in screening investment projects in the host countries, enhances FDI flows. On the other hand, host-country relative corporate-transparency diminishes the value of this expertise, thereby reducing the flow of FDI. The model also demonstrates that the gains for the host country from foreign direct investment [over foreign portfolio investment (FPI)] are reflected in a more efficient size of the stock of domestic capital and its allocation across firms. These gains are shown to depend crucially (and positively) on the degree of competition among FDI investors.
Semantic Enterprise Application Integration for Business Processes: Service-Oriented Frameworks

The lack of formal semantics of applications and services to be integrated into business processes makes it difficult for software engineers and developers to interconnect heterogeneous applications. Semantic Enterprise Application Integration for Business Processes: Service-Oriented Frameworks provides methods that incorporate and streamline processes that allow employees, decision makers, and industry partners to readily access corporate and customer data independent of where it resides. This advanced reference source provides the latest research findings in the design and development of business processes for academicians, researchers, and practitioners.
Abdominal manifestations of cystic fibrosis in older children and adults.

OBJECTIVE Cystic fibrosis (CF) is a disorder of exocrine gland function of which the gene mutation has been existing for thousands of years. With recent medical advances, neonates presently affected have a life expectancy of 40 years. The common gastrointestinal presentations of CF patients, including pancreatic, hepatobiliary, and bowel manifestations, are thus important to recognize. CONCLUSION Gastrointestinal manifestations of CF are varied yet common and thus increasingly important to recognize. The sonographic, CT, and MRI abdominal findings in older children and adults with CF are presented.
Suppression of Cyclic GMP-dependent Protein Kinase Is Essential to the Wnt/cGMP/Ca2+ Pathway*

Novel downstream effectors sensing changes in intracellular concentrations of Ca2+ and cyclic GMP in response to activation of the Wnt/Frizzled-2 pathway were sought. Activation of Frizzled-2 suppressed protein kinase G activity while activating NF-AT-dependent transcription. Each of these responses was abolished by pertussis toxin and by knock-down of the expression of either Gαt2 or Gαo. Activation of NF-AT-dependent transcription in response to Wnt5a stimulation was suppressed by activation of protein kinase G and by buffering intracellular Ca2+. Elevation of intracellular cyclic GMP either by inhibition of cyclic GMP phosphodiesterase or by addition of 8-bromocyclic GMP was shown to activate protein kinase G, to block Ca2+ mobilization, as well as to markedly attenuate activation of NF-AT-dependent transcription in response to Wnt5a stimulation. Chemical inhibition of protein kinase G by Rp-8-pCPT-cGMP, conversely, was shown to provoke increased NF-AT gene transcription and Ca2+ mobilization in the absence of Wnt stimulation. Protein kinase G is shown to be a critical downstream effector of the noncanonical Wnt-Frizzled-2/cGMP/Ca2+ pathway.
Changing Low Income Smokers’ Beliefs About Tobacco Dependence Treatment

This field study tested an intervention that challenged beliefs about the effectiveness of various quit methods held by Salvation Army client smokers from two urban locations (N = 245). Data (surveys administered immediately after and one month post-intervention) were collected 2009–2010 and analyzed using primarily χ2 and t-tests. The intervention changed client perceptions about the effectiveness of quitting methods. Compared to no-intervention controls, intervention participants reported significantly greater smoking reduction and greater likelihood of contacting the Wisconsin Tobacco Quit Line. Study implications/limitations are discussed and future research directions noted. This research was supported by grant UL1TR000427 from the Clinical and Translational Science Award (CTSA) program of the National Center for Advancing Translational Sciences, NIH.
地域協働型インフラ管理の実装に向けた行政と地域住民の役割分担に関するモデル分析;地域協働型インフラ管理の実装に向けた行政と地域住民の役割分担に関するモデル分析;Social Cost Analysis for Cooperative Road Facilities Management in the Lighting of the Role of Residents and Experts

maintenance in daily For these a system of road-facility management” whereby road facilities are maintained by various stakeholders including local municipalities, private companies, and residents are proposed. To this end, this paper addresses the sub-ject of resident partnerships involving experts and residents. More specifically, this considers the ideal approach for cooperative road-facility management by focusing on social cost analysis. In this model, resident's cost, expert's cost and risk is identified. This paper tends to analysis some cases. As a re-sult, the prospect of the road facilities management is shown by the role of the residents and the cooperative between residents and experts.
Mutual Fund Investors Expectation and Experience – A Gap Analysis from Customers’ Communication Perspective of Marketing Mix

Customer expectation and perceived experience has significant impact on the future of a product. The purpose of marketing is to identify the expectations of the customers and try to meet the customers’ expectations to the extent possible. This paper considers mutual retail fund investors as customer and attempts to study the expectation and experience gap of retail investors of mutual fund from the customer ‘communication dimension’ of marketing mix. Customer communication is one of elements of 4C concept of marketing mix. The customer communication element tries to overcome the limitation of ‘promotion’ element of 4P’s of marketing mix. The study was conducted in Guwahati and was limited to retail mutual fund investors only. A sample of 257(mutual fund investors) was selected with the help of snow ball sampling for data collection. The collected data was analyzed with the help of SPSS. Cronbach’s Alpha, Kolmogorov Smirnov test, and Paired t- test have been performed to check the reliability of scale, normality of distribution and test the hypothesis set for the study respectively. The study revealed that a significant gap exists between the expectation and perceived experience of the retail investors of the mutual fund from the customer communication dimension of marketing mix.
Research on Capital Cost Analysis of State Owned Enterprises in China

The Capital cost is one of the most important concepts in the development of state-owned enterprises, which directly determines the enterprise value and is widely used in terms of investment and financing decisions, thus plays an important role in the company's financial goals. Estimating the capital cost for businesses accurately is significant to corporate capital for financing decisions, capital investment decisions, assessment and management of working capital and other corporate performance. In this paper, taking state-owned enterprises as the research object and making a clear understanding of the structure and capital cost in the form of state-owned enterprises, focusing on the analysis method to estimate the capital cost of state-owned enterprises and taking state-owned listed companies as example to carry out empirical research.
International logistics and one‐stop shopping

One‐stop shopping for logistics services has been a popular concept in theory, but so far has not been very successful in practice. Reviews the theoretical basis for the concept and reports the findings of a shipper‐carrier comparison study about one‐stop shopping expectations for international logistics services. Shows that international shippers located in the USA rate the expected effects of one‐stop shopping as positive. Global carrier managers appear to be in tune with these shippers, although they tend to be somewhat less optimistic about the effects of one‐stop shopping. Certain shipper characteristics appear indicative of shipper enthusiasm for adopting the one‐stop shopping concept. Formulates implications of these findings for global carriers.
Innovator Mobility in Finland and Denmark

Abstract Workers have different abilities in research, development and innovation (R&D&I) activities. Firms have different “prospects for innovation”. Innovation is facilitated by matching innovators, i.e. workers that are specialized in R&D&I to firms with good prospects for innovation. Aggregate productivity growth requires that firms with the best prospects for innovation are quickly matched to innovators. The mobility of innovators is also important for positive knowledge spillovers to materialize. We use Finnish and Danish linked employer-employee data to study labour mobility, focusing on innovators. For Finland, Denmark is an interesting benchmark country because its labour market is generally considered very flexible. We find that overall labour mobility is significantly lower in Finland than in Denmark. However, relative to other occupation groups, innovators are actually more mobile in Finland than in Denmark. In Finland, innovators tend to cluster in firms that are among the most productive in their industry.
The ontology model of FrontCRM framework

Adoption and implementation of Customer Relationship Management (CRM) is not merely a technological installation, but the emphasis is more on the application of customer-centric philosophy and culture as a whole. CRM must begin at the level of business strategy, the only level that thorough organizational changes are possible to be done. Changes agenda can be directed to each departmental plans, and supported by information technology. Work processes related to CRM concept include marketing, sales, and services. FrontCRM is developed as framework to guide in identifying business processes related to CRM in which based on the concept of strategic planning approach. This leads to processes and practices identification in every process area related to marketing, sales, and services. The Ontology model presented on this paper by means serves as tools to avoid framework misunderstanding, to define practices systematically within process area and to find CRM software features related to those practices.
Phylogenetic and Transcription Analysis of Chrysanthemum WRKY Transcription Factors

WRKY transcription factors are known to function in a number of plant processes. Here we have characterized 15 WRKY family genes of the important ornamental species chrysanthemum (Chrysanthemum morifolium). A total of 15 distinct sequences were isolated; initially internal fragments were amplified based on transcriptomic sequence, and then the full length cDNAs were obtained using RACE (rapid amplification of cDNA ends) PCR. The transcription of these 15 genes in response to a variety of phytohormone treatments and both biotic and abiotic stresses was characterized. Some of the genes behaved as would be predicted based on their homology with Arabidopsis thaliana WRKY genes, but others showed divergent behavior.
Exploring the free energy and conformational landscape of tRNA at high temperature and pressure.

A combined temperature- and pressure-dependent study was employed to reveal the conformational and free-energy landscape of phenylalanine transfer RNA (tRNA(Phe) ), a known model for RNA function, to elucidate the features that are essential in determining its stability. These studies also help explore its structural properties under extreme environmental conditions, such as low/high temperatures and high pressures. To this end, fluorescence and FTIR spectroscopies, calorimetric and small-angle scattering measurements were carried out at different ion concentrations over a wide range of temperatures and pressures up to several hundred MPa. Compared with the pronounced temperature effect, the pressure-dependent structural changes of tRNA(Phe) are small. A maximum of only 15 % unpaired bases is observed upon pressurization up to 1 GPa. RNA unfolding differs not only from protein unfolding, but also from DNA melting. Its pressure stability seems to be similar to that of noncanonical DNA structures.
CORPORATE SOCIAL RESPONSIBILITY DISCLOSURE (CSRD) IN MALAYSIAN TELECOMMUNICATION COMPANIES

The Malaysian communications industry has evolved rapidly over the years and has become the most dynamic industry in the world in that it has changed a country’s economy and affected many people. In this rapid development, telecommunication companies are to strive to be socially responsible companies. Their effort is shown in the recognition awarded to these companies on their commitment in promoting and carrying out Corporate Social Responsibility (CSR) activities. This paper examined the concentration of Corporate Social Responsibility Disclosure (CSRD) on the annual report of Malaysian Telecommunication Companies. Content analysis was employed to examine the CSRD of Malaysian Telecommunication Companies in this study. Four dimensions highlighted by the Bursa Malaysia CSR Framework were used to measure the companies’ concentration on CSRD. Furthermore, this study also evaluated the most determining factors in their concentration of involvement in CSRD. Several determinants could influence the companies towards disclosing their CSR activities. CSR can increase long-term company’s profitability, sustainability and reputations were viewed as primary influencing factors. Meanwhile, CSR also improves business practices. The finding from this paper indicated that the CSRD level is increased during the period under study and concludes that Malaysian Telecommunication Companies have high initiative in CSRD with several influencing factors.
Estimating the Value of Structuring in Segmented Markets Case of Collateralized Mortgage Obligations

We develop a method to estimate value of structuring in a segmented markets. The approach is based on the understanding that a structuring entity such as investment bank stands to gain from tailoring cash flows to suit specific preferences of investors in a segmented market environment. We compute the value of each tranche conditional on the prices of other tranches. We then compare actual market prices and conditional expectations. The greater the mismatch between actual prices and conditional expectations, the larger is the value of structuring.
Timeline control for customized presentation over MMT-based streaming

Customized presentation is gaining more popularity. The MPEG media transport (MMT) system provides flexible media unit encapsulation and comprehensive control signaling to support multiple content types that may be useful during the customization. Existing legacy methods, however, did not take into account relations within media asset and the combination of diverse media components. Furthermore, considering more complex scenarios such as transmissions over heterogeneous networks and various user behaviors, a flexible timeline control scheme is essential for achieving smooth and precise playback. For better catering to the requirements of customized presentation, this paper proposes a new timeline scheme that can quickly respond to user interactions and generate the timeline via proper signaling. Experiments validate that the newly developed method successfully controls the presentation process of customized requests in MMT system.
Small loop rectenna for RF energy harvesting

This paper presents a small loop antenna and high output voltage rectifier in wide frequency band for RF(radio frequency) energy harvesting of FM broadcasting signals. Target input power level of -20dBm is used to design a loop antenna for DC output voltage-boosting. The RF energy harvesting on suburb area provides 924mV DC output for a single rectenna and 1.72V DC output for twin rectennas by receiving several FM broadcasting signals simultaneously.
Hedge Funds and Chapter 11

This paper studies the presence of hedge funds in the Chapter 11 process and their effects on bankruptcy outcomes. Hedge funds strategically choose positions in the capital structure where their actions could have a bigger impact on value. Their presence, especially as unsecured creditors, helps balance power between the debtor and secured creditors. Their effect on the debtor manifests in higher probabilities of the latter’s loss of exclusive rights to file reorganization plans, CEO turnover, and adoptions of key employee retention plan, while their effect on secured creditors manifests in higher probabilities of emergence and payoffs to junior claims. THIS PAPER EXAMINES THE roles of hedge funds in Chapter 11 and the effects of their presence on the nature and outcome of the bankruptcy process. Hedge funds’ participation in the bankruptcy process takes a variety of forms, including investing in debt claims, buying equity stakes, serving on the unsecured creditors or equity committee, and pursuing a “loan-to-own” strategy, whereby a hedge fund acquires the debt of a distressed borrower with the intention of converting the acquired position into a controlling equity stake upon the firm’s emergence from Chapter 11. Using a comprehensive sample of 474 Chapter 11 cases from 1996 to 2007 formed by merging a variety of data sources, we show that hedge fund presence
Intelligibility assessment in forensic applications

In the context of forensic phonetics the transcription of intercepted signals is particularly important. However, these signals are often degraded and the transcript may not reflect what was actually pronounced. In the absence of the original signal, the only way to see the level of accuracy that can be obtained in the transcription of poor recordings is to develop an objective methodology for intelligibility measurements. This study has been carried out on a corpus specially built to simulate the real conditions of forensic signals. With reference to this corpus a measurement system of intelligibility based on STI (Speech Transmission Index) has been evaluated so as to assess its performance. The result of the experiment shows a high correlation between objective measurements and subjective evaluations. Therefore it is recommended to use the proposed methodology in order to establish whether a given intercepted signal can be transcribed with sufficient reliability.
The Role of Brand Parity in Developing Loyal Customers

ABSTRACT Perceived brand parity is the belief in the consumers mind that major offerings in a product category are similar. The current article presents the results of a study indicating that high parity perceptions inhibit a company's ability to develop loyal customers. Whether that is good or bad depends on the type of competitive strategy a firm has chosen. With a differentiation strategy, advertising should be used to fight parity perceptions. However, with a low price strategy, parity perceptions should be fostered in an attempt to discourage brand loyalty. Thus, a starting point for many advertising campaigns should be a clear understanding of both the parity perceptions in the marketplace and the need to either develop or fight brand loyalty.
Immunization of cattle with the MSP-1 surface protein complex induces protection against a structurally variant Anaplasma marginale isolate

The Anaplasma marginale surface protein complex MSP-1 of the Florida isolate is composed of a 105-kilodalton (kDa) polypeptide, which bears a neutralization-sensitive epitope, and a 100-kDa polypeptide. Antigenically similar polypeptides in the Okanogan, Wash. (Washington-O), isolate MSP-1 are 86 and 100 kDa, respectively. Immunization of cattle with Florida isolate MSP-1 induced antibody titers to both MSP-1 polypeptides and protected cattle against homologous and heterologous challenge.