Miracle-dz/UniFAR-FTUs huggingface dataset:
THE APOPTOTIC EFFECT OF RESVERATROL ON HUMAN PAPILLOMA VIRUS POSITIVE CASKI CELL-LINE: A TIME AND DOSE DEPENDENCE STUDY.

Background & objectives: Resveratrol (trans-3,4,5’ –trihydroxystilbene) is an active compound in food, such as redgrapes, peanuts, and berries. A body of evidence shows that resveratrol is able to inhibit thegrowth of many cancers such as leukemia, breast cancer and primary brain tumors. The objective of the present study was to demonstrate the dose and time dependent apoptotic effect of Resveratrol on Human Caski cell line. Methods: We used cell viability assays like MTT and Trypan blue assays to demonstrate the inhibition of cancer cell proliferation in a dose and time dependent manner. Results: Our results have shown that Resveratrol inhibited proliferation of Caski cells in a concentration and time dependent manner in 48 hr cultures. No significant effect was observed in 24 hour cultures of cell viability assays. Interpretation & conclusions: The results indicated that Resveratrol and NAC inhibited cell growth in Caski cells as a function of dose and time. Keywords: Resveratrol , Cervical cancer, apoptosis
Untersuchungen des visuellen Systems in der Neurologie: aktuelle Forschung und klinische Relevanz

Zusammenfassung Die orientierende Darstellung des afferenten visuellen Systems ist integraler Bestandteil der neurologischen Anamnese und der klinisch neurologischen Untersuchung. Durch die anatomische Zugehörigkeit zum zentralen Nervensystem, das Auftreten von Sehverlust bei vielen neurologischen Erkrankungen, und durch die erhebliche Bedeutung eines Sehverlustes für die Lebensqualität von Betroffenen erfährt die Untersuchung des afferenten visuellen Systems durch moderne diagnostische Verfahren zunehmende Bedeutung. Niedrigkontrast-Sehen oder Farbsehtests können klassische Visustests ergänzen. Mithilfe von multifokal visuell evozierten Potenzialen können einzelne Stränge der Sehbahn untersucht werden. Optische Kohärenztomografie erlaubt die hochaufgelöste Darstellung der Netzhaut mit ihren einzelnen Schichten. Diffusionsbildgebung und funktionelle Magnetresonanztomografie erlauben in der Forschung die mikrostrukturelle und funktionelle Untersuchung des visuellen Systems. Strukturierte Fragebögen können für das Screening auf Sehstörungen genutzt werden. Eine detaillierte Untersuchung des afferenten visuellen Systems gehört zunehmend zur erweiterten neurologischen Untersuchung bei neuroimmunologischen Erkrankungen wie Multiple Sklerose, Neuromyelitis optica, MOG-IgG assoziierter Enzephalomyelitis oder Susac-Syndrom, aber auch beim Parkinson Syndrom oder anderen neurodegenerativen Erkrankungen. Dieser Übersichtsartikel skizziert die Prinzipien der wichtigsten Methoden zur strukturellen und funktionellen Untersuchung des visuellen Systems und fasst exemplarisch die Ergebnisse der Anwendung dieser Methoden bei relevanten neurologischen Erkrankungen zusammen.
Management of bicondylar tibial plateau fractures with severe articular comminution by ligamentotaxis with biplanar spanning external fixation

Background: Bicondylar tibial plateau fractures are serious injuries with a high incidence of complications. The fracture treatment protocol has to take into consideration soft-tissue complications that might develop with severe articular comminution. This prospective study aims at highlighting the role of ligamentotaxis and spanning external fixation as an effective method in treatment of such injuries. Methods: Twenty-three patients were admitted with bicondylar tibial plateau fractures. Seventeen men and six women with severe intraarticular comminution were treated with ligamentotaxis and fixation with two spanning external fixators. Patients were followed for 2 yr. Functional outcome was assessed using the Knee Society Scoring System directly after removal of the fixators then at 1 and 2 yr. Results: The scores of the patients ranged from 94-72, with an average of 82.4. Seven of the patients had an excellent score (80-100), and five had a good score (70-79). Conclusions: Ligamentotaxis and spanning external fixation is a safe and successful method for treatment of severely comminuted bicondylar tibial plateau fractures. This technique allows achievement of an acceptable reduction with avoidance of skin and soft-tissue complications. Level of Evidence: Level IV therapeutic study.
DataSlicer: Enabling Data Selection for Visual Data Exploration

Determining how to select and transform the data for visualization is one of the hardest problems faced by dataunfamiliar or inexperienced users when performing a visual exploration to solve an analytical task. Our main hypothesis is that for many data sets and common analytical tasks, such as finding outliers or general trends in data, there are relatively few “data slices” that are key to providing effective visualizations for the task. By focusing human users on appropriate and suitably transformed parts of the underlying data sets, these data slices can help the users carry their task to correct completion. To verify this hypothesis, we develop a framework that permits us to capture exemplary data slices in an exploration task, and to explore and parse visual-exploration sequences into a format that makes them distinct and easy to compare. We develop a recommendation system, DataSlicer, that matches a “currently viewed” data slice with the most promising “next effective” data slices for the given exploration task. We report the results of controlled experiments with an implementation of the DataSlicer system, using four common analytical task types. The experiments demonstrate statistically significant improvements in accuracy and exploration speed versus users without access to our system.
A simplified continuous phase modulator technique

A low cost GMSK (Gaussian minimum shift keying) modulation technique is presented. GMSK is chosen as an example although the technique is suitable for any continuous phase constant envelope modulation with discriminator, differential or coherent detection in the targeted receiver. In this technique, a fractional-N synthesizer is used to control the instantaneous frequency and phase of the phase locked synthesizer output. As a result of this approach, no in-phase and quadrature mixer or D/A converters are required. Furthermore, the desired signal can be generated directly at RF with no IF conversion stages. The look-up table to generate the modulation is only one bit wide. /spl Delta/-/spl Sigma/ techniques are used to obtain high accuracy through the long term average of a sequence of the single bits. The narrow band filtering of the transmit data is accomplished in two parts, a precise digital linear phase band-reject part using the one bit stored ROM look-up table and a less precise low pass analog part inherent to the PLL of the synthesizer. >
The Intensivists' Exposure to Tricyclic Antidepressants

journal [1] on the use of tricyclic antidepressants in the intensive care unit (ICU) addresses two distinct and important groups of patients. The first group is composed of patients who attempt suicide by overdose with tricyclics. Most overdose patients who reach an ICU survive [2]. Most are quite stable within 24 to 48 hours and often do not require transfer to a general medical ward. This situation puts critical care specialists in the position of dealing with the suicidal patient, usually in an emotion-
Astrocytes: Puzzle in Neurodegeneration

Understanding brain complexity and occurrence of brain diseases is still a challenge for researchers. Despite of extensive research in this area the pathology of brain diseases is still enigmatic and incites us to further explore the disease initiation, progression and manifestation of degenerative mechanisms. To date research findings have implied that most of the brain disease pathologies involve the analogous cell death mechanisms except the decreased level of specific neurotransmitters. The decreased level of neurotransmitter occurs due to loss of specific neuronal population which is well explored for the particular brain disease. However, the role of non-neuronal cells, which constitute approximately ninety percent of brain cells population, is still underappreciated in occurrence of disease initiation and progression. The neuroscientists are still inquisitive to comprehend their explicit and dynamic role in brain disease pathology. There are two kinds of hypotheses and believers are working in this research area. One scientific group is not accepting the functional role of the non-neuronal cells in brain disease pathology whereas the other group has shown and further exploring the role of such foremost non-neuronal population in brain disease pathology. Such controversial outlook of neuroscientist worldwide is might be due to several gaps and limited knowledge regarding their function and interaction with neuronal cells in brain. Previously the non-neuronal cells were considered as only supporting cells in brain anatomy. However, studies of last two decade have suggested their functional role in neuropathology [1-6]. Among non-neuronal cells the astrocytes and microglia are the most studied cells. In this article we are addressing the astrocytes related issue but other non-neuronal cells have their own vibrant involvement in brain disease and must be studied further.
The impact of food choice on diet quality during weight loss: insights from intervention trials

University of Wollongong Copyright Warning You may print or download ONE copy of this document for the purpose of your own research or study. The University does not authorise you to copy, communicate or otherwise make available electronically to any other person any copyright material contained on this site. You are reminded of the following: This work is copyright. Apart from any use permitted under the Copyright Act 1968, no part of this work may be reproduced by any process, nor may any other exclusive right be exercised, without the permission of the author. Copyright owners are entitled to take legal action against persons who infringe their copyright. A reproduction of material that is protected by copyright may be a copyright infringement. A court may impose penalties and award damages in relation to offences and infringements relating to copyright material. Higher penalties may apply, and higher damages may be awarded, for offences and infringements involving the conversion of material into digital or electronic form. Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.
Gravity highlights a dual role of the insula in internal models

Movements rely on a mixture of predictive and reactive mechanisms. With experience, the brain builds internal representations of actions in different contexts. Many factors are taken into account in this process among which the immutable presence of gravity. Any displacement of a massive body in the gravitational field generates forces and torques that must be predicted and compensated by appropriate motor commands. Studies have shown that the insular cortex is a key brain area for graviception. However, none attempted to address whether the same internal representation of gravity is shared between reactive and predictive mechanisms. Here, participants either mentally simulated (only predictive) or performed (predictive and reactive) vertical movements of the hand. We found that the posterior part of the insular cortex was engaged when feedback was processed. The anterior insula, however, was activated only in mental simulation of the action. A psychophysical experiment shows participants’ ability to integrate the effects of gravity. Our results demonstrate a dual internal representation of gravity within the insula and discuss how they can conceptually be linked.
Charakterisierung der Verteilung lysosomaler Zystein- und Asparaginproteasen in der menschlichen Lunge und ihre Bedeutung bei der Prozessierung des Surfactant Proteins B

Ziel der vorliegenden Studie war es, die Verteilung der Zystein- (Kathepsin B, H, K, L und S) und Asparaginproteasen (Kathepsin D, E und Napsin A) in der menschlichen Lunge zu charakterisieren. Ein besonderes Augenmerk lag auf der Fragestellung, welche Enzyme aufgrund ihrer Lokalisation in die Prozessierung des Surfactant Proteins B involviert sein konnen. Bei den Zystein- und Asparaginproteasen handelt es sich um zwei Familien lysosomaler Enzyme. Mittels der Immunhistochemie und elektronenmikroskopie wurde die Verteilung der Enzyme in der Lunge untersucht. Die Studie ergab, das aufgrund ihrer Lokalisation nur Kathpesin H und Napsin A in Typ-II-Pneumozyten und den Clara-Zellen der Lunge in die Prozessierung des Surfactant Proteins B involviert sein konnen.
Pharmacogenetics of Psychotropic Drugs

Part I. Introduction: 1. Genes and psychopharmacology: exploring the interface Bernard Lerer Part II. Clinical Background and Research Design: 2. From pharmacogenetics to pharmacogenomics of psychotropic drug response Anil K. Malhotra 3. Neuropsychopharmacology: the interface between genes and psychiatric nosology Thomas A. Ban 4. Methodological issues in psychopharmacogenetics Sheldon H. Preskorn 5. Statistical approaches in psychopharmacogenetics Fabio Macciardi Part III. Molecular Background: 6. The psychopharmacogenetic-neurodevelopmental interface in serotonergic gene pathways K. Peter Lesch, Jens Benninghoff and Angelika Schmitt 7. RNA processing regulation and interindividual variation Colleen M. Niswender and Linda K. Hutchinson Part IV. Pharmacokinetics: 8. Pharmacogenetics of psychotropic drug metabolism Vural Ozdemir, Angela D. M. Kashuba, Vincenzo S. Basile and James L . Kennedy 9. Pharmacogenetics of chiral psychotropic drugs Pierre Baumann and Chin B. Eap Part V. Specific Psychotropic Drugs and Disorders: 10. Clozapine response and genetic variation in neurotransmitter receptor targets David A. Collier, Maria J. Arranz, Sarah Osborne, Katherine J. Aitchison, Janet Munro, Dalu Mancama and Robert W. Kerwin 11. Genetic factors underlying drug-induced tardive dyskinesia Ronnen H. Segman and Bernard Lerer 12. Functional gene-linked polymorphic regions in pharmacogenetics Marco Catalano 13. Alternative phenotypes and the pharmacogenetics of mood and anxiety disorders Emanuela Mundo and James L. Kennedy 14. Pharmacogenetics of anxiolytic drugs and the GABA-benzodiazepine receptor complex Smita A. Pandit, Spilios V. Argyropoulous, Patrick G. Kehoe and David J. Nutt 15. Genetic factors and long-term prophylaxis in bipolar disorder Martin Alda 16. Genetic influences on responsiveness to anticonvulsant drugs Thomas N. Ferraro 17. Apolipoprotein E as a marker in the treatment of Alzheimer's disease Keith Schappert, Pierre Sevigny and Judes Poirier 18. Genetic variation and drug dependence risk factors Joel Gelernter and Henry Kranzler Part VI. Pharmacogenetics and Brain Imaging: 19. Brain imaging and pharmacogenetics in Alzheimer's disease and schizophrenia Steven G. Potkin, James L. Kennedy and Vincenzo S. Basile Part VII. Industry perspectives: 20. Pharmacogenetics in psychotropic drug discovery and development William Z. Potter, AnnCatherine Van Lone and Larry Altstiel 21. High-throughput single nucleotide polymorphism genotyping Anne Shalom and Ariel Darvasi Index.
Adapting to climate change at the national level in Caribbean small island developing state

Small island developing states (SIDS) are distinct from other developing countries: they are particularly and comparatively more vulnerable to the impacts of climate change. Efforts to understand national-level vulnerability in these countries are limited. This paper helps to fill this gap and has two main aims. First, it identifies trends in national-level climate change adaptation among SIDS in the Caribbean region. Second, it identifies the limits to adaptation at the national level in these countries. In applying a resilience lens, and using summative content analysis techniques and semi-structured interviews with 26 senior policy-makers, this paper finds that Caribbean SIDS are primarily adapting to changes in hurricane, rainfall, and drought patterns. It also finds that most adaptations are being undertaken in the coastal zone and the water and agriculture sectors, and that there are many factors limiting national-level adaptation. The most commonly reported limit is financing, though not all policy-makers agree that financing is a limit. These findings are important for national SIDS governments and international donors and agencies that will be better able to identify and fill gaps in their adaptation actions and financing. This paper’s findings also highlight the importance of depoliticising climate change and prioritising good governance, improving SIDS’ access to international adaptation financing, and making the road to a climate-resilient future by walking.
Dermatologische Externa im Kindesalter

Zusammenfassung Die kindliche Haut bietet verglichen mit Erwachsenen weniger morphologische als vor allem funktionelle Besonderheiten, die für die topische Applikation von Wirksubstanzen von praktischer Bedeutung sind. Um die Zusammenhänge bewerten zu können, sind Grundkenntnisse von der physikochemischen Organisation des Stratum corneums als Grenzkompartiment zwischen Präparation und vitaler Epidermis von essenzieller Bedeutung. Zudem bedarf es eines Grundverständnisses von galenischen Abläufen und Interaktionen, um Behandlungssituationen hinsichtlich einer individuellen Nutzen-Risiko-Bewertung beurteilen zu können. Insgesamt wird deutlich, dass praktisch relevante Risiken insbesondere bei pathologisch veränderter Haut mit Defekten der physikalischen Barriere- und Reservoir-funktion, bei Wärmeeinwirkung und unter Okklusion beachtet werden müssen. Diese liegen vor allem in einer erhöhten systemischen Bioverfügbarkeit mit toxikologischer Relevanz und in irritativen Effekten insbesondere durch Emulgatorwirkungen. Besonders bedeutsam ist im klinischen Alltag der Umgang mit arzneilichen Präparationen, die nicht für die Anwendung im Kindesalter zugelassen sind (Off-label-use). Hierbei gelten besondere juristische Rahmenbedingungen, die eine besondere Sorgfalt in der Therapiewahl voraussetzen.
Slack financier et forte croissance dans la PME

Historiquement, la notion de slack a ete avancee par l'approche ressources (Penrose, 1959) pour expliquer la croissance. Paradoxalement, face aux arguments de ses detracteurs (relevant principalement de la theorie de l'agence), les etudes empiriques se sont surtout attachees a etudier le role d'un slack dans la performance de l'entreprise, celle-ci etant essentiellement mesuree en termes de profit. Ces etudes ont abouti a des resultats tres contrastes, mais avec tout de meme la mise en evidence de divers types de slack aux fonctions potentiellement assez differentes dans la performance. L'intention generale de cette etude est de tester empiriquement d'une part les types de slack financier qui influencent ou non la croissance et d'autre part ceux qui contribuent le plus a l'entree en forte croissance. Les resultats temoignent au final de l'influence de deux types de slack sur la forte croissance : un slack potentiel (la capacite d'endettement) et un slack absorbe (la rotation des actifs). La croissance forte reposerait davantage sur la capacite de l'entreprise a tirer parti de ses ressources, que sur des niveaux de ressources en soi.
Smartphones Give You Wings: Pedagogical Affordances of Mobile Web 2.0

Built on the foundation of four years of research and implementation of mobile learning projects (m-learning), this paper provides an overview of the potential of the integration of mobile Web 2.0 tools (based around smartphones) to facilitate social constructivist pedagogies and engage students in tertiary education. Pedagogical affordances of mobile Web 2.0 tools are evaluated, and student usage and feedback is outlined via an interactive multimedia timeline (using YouTube videos) illustrating how these mobile Web 2.0 pedagogical affordances have transformed pedagogy and facilitated student engagement in a variety of course contexts. A rubric for evaluating appropriate smartphone choices is provided, and a model for implementing mobile Web 2.0 pedagogical integration is presented.
A HOMONÍMIA NO PORTUGUÊS: TRATAMENTO SEMÂNTICO SEGUNDO A ESTRUTURA QUALIA DE PUSTEJOVSKY COM VISTAS A IMPLEMENTAÇÕES COMPUTACIONAIS

No presente trabalho, apresentamos uma proposta de tratamento semântico de formas ambiguas do portugues do Brasil, no caso, lexias homografas, com o escopo de oferecermos estrategias linguisticas para a sua implementacao computacional em Sistemas de Processamento das Linguas Naturais (SPLN). O Lexico Gerativo de Pustejovsky foi usado como modelo teorico. Nesse modelo, a Estrutura Qualia - EQ (e os papeis Formal, Telico, Agentivo e Constitutivo) foi selecionada como um dos expedientes linguistico-semânticos para a realizacao da desambiguacao das formas homonimas. Para que os dados analisados e tratados pudessem ser manipulados, elaboramos uma Base de Conhecimento Lexical (BCL) cujo repertorio linguistico possui seus itens lexicais correlacionados e interligados por diferentes tipos de relacoes semânticas presentes na EQ.
A technique for Parameterized verification of cache coherence protocols

This paper introduces a technique for scalable functional verification of cache coherence protocols that is based on the verification method, which was previously developed by the author. Scalability means that verification efforts do not depend on the model size (that is, the number of processors in the system under verification). The article presents an approach to the development of formal Promela models of cache coherence protocols and shows examples taken from the Elbrus-4C protocol model. The resulting formal models consist of language constructs that directly reflect the way protocol designers describe their developments. The paper describes the development of the tool, which is written in the C++ language with the Boost.Spirit library as parser generator. The tool automatically performs the syntactical transformations of Promela models. These transformations are part of the verification method. The procedure for refinement of the transformed models is presented. The refinement procedure is supposed to be used to eliminate spurious error messages. Finally, the overall verification technique is described. The technique has been successfully applied to verification of the MOSI protocol implemented in the Elbrus computer systems. Experimental results show that computer memory requirements for parameterized verification are negligible and the amount of manual work needed is acceptable.