Miracle-dz/UniFAR-FTUs huggingface dataset:
Insights on the Structural Characteristics of NDM-1: The Journey so Far

New Delhi metallo-β-lactamase (NDM-1) has created a medical storm ever since it was first reported; as it is active on virtually all clinically used β-lactam antibiotics. NDM-1 rampancy worldwide is now considered a nightmare scenario, particularly due to its rapid dissemination. An underlying theme in the majority of recent studies is structural characterization as knowledge of the three-dimensional structure of NDM-1 shall help find connections between its structure and function. Moreover, structural details are even critical in order to reveal the resistance mechanism to β-lactam antibiotics. In this perspective, we review structural characteristics of NDM-1 that have been delineated since its first report. We anticipate that these structure-function connections made by its characterization shall further serve as future guidelines for elucidating pathways towards de novo design of functional inhibitors.
Distressing Sexual Problems and Dyadic Adjustment in Heterosexuals, Gay Men, and Lesbian Women

Empirical studies have focused on dyadic adjustment and sexual satisfaction in men and women. Nevertheless, little is known regarding the role of dyadic adjustment in sexual problems among individuals in same-sex and mixed-sex dyads. The aim of the current study was to analyze the differences in dyadic adjustment between gay and heterosexual men, and lesbian and heterosexual women, with and without distressing sexual problems. One hundred and sixty men (80 gay and 80 heterosexual) and 184 women (92 lesbian and 92 heterosexual) completed an online survey. Participants responded to the Dyadic Adjustment Scale–Short Version and to questions about self-perceived sexual problems and associated levels of distress. A 2 (gender) × 2 (sexual orientation) × 2 (group with or without sexual problems) univariate analysis of covariance was performed. The findings suggested that individuals with distressing sexual problems, regardless of gender or sexual orientation, scored significantly lower on the Dyadic Adjustment Scale. Additionally, lesbian women, regardless of having or not having a distressing sexual problem, scored significantly higher on the Dyadic Adjustment Scale, compared to heterosexual women. No gender differences were found. Overall, our findings emphasize the negative association between dyadic adjustment and distressing sexual problems, regardless of gender and sexual orientation.
Understanding group-buying websites continuance: An extension of expectation confirmation model

Purpose – Sustainable success of group-buying web sites implies that consumers not only accept them initially but also use them continuously. Most group-buying web sites, however, are unable to achieve such sustainable success. Drawing on expectation-confirmation model (ECM), the purpose of this paper is to examine the factors that influence group-buying web sites continuance. Design/methodology/approach – In total, 605 valid responses were collected via a survey of a leading group-buying web site in China. Structural equation modeling was used to test the research model. This study also compared the three competing models of continued use behavior, namely, ECM, the research model and the integrated model. Findings – The results show that perceived web site quality, perceived price advantage and confirmation are important determinants of consumer satisfaction, while perceived web site quality, perceived reputation, satisfaction and perceived critical mass significantly influence consumers’ continuance int.
Performance evaluation of a new design of cable-suspended camera system

Adaptive cable-driven parallel robots can adjust the position of one or more pulley blocks to optimize performance within a given workspace. Because of their augmented kinematic redundancy, adaptive systems have several advantages over their traditional counterparts featuring the same numbers of cables. In this paper, we explore the application of adaptive cable-driven robots to cable-suspended camera systems. Performance of the traditional and of the adaptive designs are analyzed, using dexterity and stiffness as performance metrics. Results show superior performance of the adaptive design compared to the traditional system. An illustrative design problem for adaptive cable-suspended camera systems is also presented and solved.
CO chemisorption at metal surfaces and overlayers.

A database of ab initio calculations of the chemisorption energy of CO over Ni(111), Cu(111), Ru(0001), Pd(111), Ag(111), Pt(111), Au(111), Cu3Pt(111), and some metallic overlayer structures is presented. The trends can be reproduced with a simple model describing the interaction between the metal d states and the CO 2p p and 5s states, renormalized by the metal sp continuum. Our model rationalizes the results by Rodriguez and Goodman [Science 257, 897 (1992)] showing a strong correlation between the CO chemisorption energy and the surface core level shift. Over the past three decades the field of surface science has produced a series of accurate spectroscopical techniques that can provide detailed information about the electronic structure at surfaces [1]. It would be extremely useful if spectroscopic data could also be used directly to give information about the chemical activity of the surface. This would open up new possibilities in the future search for, e.g., more efficient catalysts. Recently, Rodriguez and Goodman [2] have established a spectacular correlation between spectroscopical data (surface core level shifts) and the chemisorption energy of CO on a series of metal surfaces and overlayers. If such an approach can be generalized, we would have a means of predicting the chemical activity of surfaces based on the surface electronic properties alone. In the present Letter, we discuss the physics of CO adsorption over metal surfaces and overlayers by presenting an extensive ab initio database of CO chemisorption energies calculated within density functional theory (DFT) using the generalized gradient approximation (GGA). We demonstrate that the trends in the database can be understood using a simple two-level model describing the coupling of the CO 5s and 2p p states to the metal d va
Capacitated lot sizing in a dynamic make-to-order production environment with practical inventory restrictions on warehouses

Disclaimer This document contains a student thesis (bachelor's or master's), as authored by a student at Eindhoven University of Technology. Student theses are made available in the TU/e repository upon obtaining the required degree. The grade received is not published on the document as presented in the repository. The required complexity or quality of research of student theses may vary by program, and the required minimum study period may vary in duration.
Dietary Protein and Resistance Training Effects on Muscle and Body Composition in Older Persons

The regular performance of resistance exercises and the habitual ingestion of adequate amounts of dietary protein from high-quality sources are two important ways for older persons to slow the progression of and treat sarcopenia, the age-related loss of skeletal muscle mass and function. Resistance training can help older people gain muscle strength, hypertrophy muscle, and increase whole body fat-free mass. It can also help frail elderly people improve balance and physical functioning capabilities. Inadequate protein intake will cause adverse metabolic and physiological accommodation responses that include the loss of fat-free mass and muscle strength and size. Findings from controlled feeding studies show that older persons retain the capacity to metabolically adjust to lower protein intakes by increasing the efficiency of nitrogen retention and amino acid utilization. However, they also suggest that the recommended dietary allowance of 0.8 g protein · kg−1 · d−1 might not be sufficient to prevent subtle accommodations and blunt desired changes in body composition and muscle size with resistance training. Most of the limited research suggests that resistance training-induced improvements in body composition, muscle strength and size, and physical functioning are not enhanced when older people who habitually consume adequate protein (modestly above the RDA) increase their protein intake by either increasing the ingestion of higher-protein foods or consuming protein-enriched nutritional supplements.
HDAT: web-based high-throughput screening data analysis tools

The increasing utilization of high-throughput screening (HTS) in toxicity studies of engineered nano-materials (ENMs) requires tools for rapid and reliable processing and analyses of large HTS datasets. In order to meet this need, a web-based platform for HTS data analyses tools (HDAT) was developed that provides statistical methods suitable for ENM toxicity data. As a publicly available computational nanoinformatics infrastructure, HDAT provides different plate normalization methods, various HTS summarization statistics, self-organizing map (SOM)-based clustering analysis, and visualization of raw and processed data using both heat map and SOM. HDAT has been successfully used in a number of HTS studies of ENM toxicity, thereby enabling analysis of toxicity mechanisms and development of structure? activity relationships for ENM toxicity. The online approach afforded by HDAT should encourage standardization of and future advances in HTS as well as facilitate convenient inter-laboratory comparisons of HTS datasets.
Towards a national certification scheme forRubusin the United States

Acta Hortic. 1133. ISHS 2016. DOI 10.17660/ActaHortic.2016. 1133.74 Proc. XI Int. Rubus and Ribes Symp. Eds.: G.E. Fernandez and K.E. Hummer 483 Towards a national certification scheme for Rubus in the United States R.C. Gergerich1, I.E. Tzanetakis1 and R.R. Martin2 1Department of Plant Pathology, Division of Agriculture, University of Arkansas System, Fayetteville, Arkansas, USA; 2USDA ARS, Horticulture Crops Research Unit, Corvallis, Oregon, USA.
On solving bounded fuzzy variable linear program and its applications

In recent years various attempts have been made to study the solution of fuzzy variable linear programming problems by introducing and solving certain auxiliary problems or directly by the use of dual simplex method based on a certain linear ranking function. But these methods are not applicable for situations in which some or all variables are restricted to lie within fuzzy lower and fuzzy upper bounds. In this paper, as a natural extension of the results in crisp linear programming and based on a certain linear ranking function we obtain some new results leading to a new method to overcome this shortcoming. To show the application of our method a real life problem is solved by using the proposed method. Also, one application of this approach in solving maximum flow problem with fuzzy capacity is dealt with.
Internal Limiting Membrane Peeling During Idiopathic Epiretinal Membrane Removal: Literature Review

Idiopathic epiretinal membrane (ERM) is characterized by the growth of fibrocellular tissue on the internal limiting membrane (ILM). An ERM can range from a subtle cellophane-like film that does not cause any visual disturbance to a significant, multilayered, contractile membrane with folds in the underlying and adjacent retina, causing metamorphopsia and a decline in visual acuity. Although the exact pathogenesis of ERM formation is unclear, it is known to be associated with posterior vitreous detachment leading to hypertrophy of glial (Muller) cell processes and the accumulation of extracellular matrix components on the ILM. The ILM is the basement membrane of the Muller cells.
Genetic relationships in familial leukemia and lymphoma.

Thirty-nine multiple family cases have been recorded with 77 pairs and 91 involved relatives having leukemia or lymphoma. Thirty-two of the 39 families involved a close genetic relationship between affected siblings or parent-child pairs. The multiple family case members died earlier than single family case members on a comparative study. This suggests that genetic factors are of importance in the etiology of these malignant hematologic proliferations.
Project Galore: Qualitative Research and Leveraging Scotland's Brand Equity

ABSTRACT Project Galore was set up to develop a strategy to leverage the commercial power of Scottishness - its brand equity. This paper describes how Scotland could reconcile its past with its present and develop an offer that could span people and products. It then covers the research. This was conducted in seven countries among trade buyers and consumers to discuss with them how best Scotland should present itself to be both credible and motivating.
Genetic Testing on Electrowetting-on-dielectric Chips for Magnetic Bead-based DNA Extraction

To develop and realize the personalized medicine and point-of-care in genetic testing, the sequences of DNA extraction process should be integrated. This thesis introduces the implementation of magnetic beads (MB) based DNA extractions on electrowetting on electrowetting-based digital microfluidics (DMF). The reagents are DNA extraction kit. They are characterized as a droplet on DMF. These droplets can be precisely manipulated by electric signals, which simplifies the whore genetic testing. The result from the on-chip DNA of extraction are validated by SYBR® GREEN 1. DNA is successfully extracted from 90nl whole blood. Finally, our EWOD chip has been optimized in the following three aspects: (1) it has independent paths of the electrodes for different reagent to avoid the cross-contamination problem. (2) It utilizes MBs to replace the complex centrifugation in tradition DNA extraction procedures. (3) Ratio separation electrodes are designed to re-suspend the MBs and to improve the efficiency of the wasting process. Therefore, our DMF chip not only can successfully extract the DNA from whole blood, but also demonstrate the possibility to use less sample/reagent and shorter process time to purify DNA on chip for point- of-care genetic testing.
Engineering of FePt nanoparticles by e-beam co-evaporation

Fe50Pt50 nanoparticles were deposited on thermally oxidized Si substrates by electron-beam co-evaporation of Fe and Pt, at substrate temperatures Ts between 300 and 700 °C. The co-deposition led to the formation of drop-like, coalesced nanoparticles, chain-like structures or continuous films, the morphology being dependent on Ts or the nominal thickness of the layer, f. The nanoparticles have a mean diameter Dp between 3 and 45 nm, which increases with increasing f. The degree of crystallization in the ordered face centred tetragonal (fct) phase of the samples depends strongly on the growth conditions and increases with increasing Ts and f. Nanoparticles with a higher proportion of the fct phase exhibit higher coercivity, with a maximum value of ∼10.3 kOe (for the specimens prepared at 600 °C with f = 8.5 nm). Conversely, samples with a high proportion of the cubic phase are either superparamagnetic or ferromagnetically soft. The thermal annealing performed on selected samples resulted in structural transformation as well as magnetic hardening that depended on f and Dp.
Genome evolution-aware gene trees Method

A gene family tree is traditionally inferred from a multiple alignment of homologous sequences according to a model of sequence evolution. Trees for several genes families are thus constructed independently from each other. They often carry unresolutions or bad resolutions. Information for their full resolution may lie in the poorly exploited dependency between gene families, each bringing information for the resolution of the others. We propose to use several kinds of such dependencies in the construction of gene trees: information from a species tree through a model of gene content evolution by duplication, speciation and loss, information from extant synteny through ortholog predictions, and information from ancestral synteny through a model of gene neighborhood evolution. We develop several “correction” techniques, yielding a software package called “RefineTree”. We report some tests on simulated data and an application on the full set of gene families from the Ensembl database. We perform a genome-wide analysis of duplication and loss patterns on the history of 65 eukaryote species, including ancestral genes and gene orders of all ancestors along this phylogeny. We show that according to several measures including running time, likelihood, stability of genome content and linearity of ancestral chromosomes, trees corrected by RefineTree are arguably more plausible than the ones stored by Ensembl. We discuss the quality criteria in the light of gene definition as a sequence or as a locus. We extract some cases where a “true” gene tree should depend on this definition. RefineTree web interface is available at: http://www-ens.iro. umontreal.ca/~adbit/polytomysolver.html
Dissociation of glomerular filtration rate from tubulointerstitial fibrosis in experimental chronic cyclosporine nephropathy: role of sodium intake.

In addition to its well-recognized ability to provoke acute renal dysfunction by promoting intense renal vasoconstriction, cyclosporine produces a chronic tubulointerstitial nephropathy characterized by striped interstitial fibrosis in humans. With a model of chronic cyclosporine nephropathy in which striped fibrosis develops in the uninephrectomized salt-depleted rat, the relationship between renal functional impairment and structural changes was studied during cyclosporine treatment and after its withdrawal in order to ascertain the natural history of this lesion. Groups of uninephrectomized rats maintained on a salt-depleted (-NaCl) or salt-replete (+NaCl) diet were treated with cyclosporine, 15 mg/kg per day, or vehicle by sc injection. GFR and morphology were assessed at 14 and 28 days of treatment and at intervals up to 28 days after drug withdrawal. Although GFR was similarly depressed in cyclosporine-treated animals on either diet (P < 0.001 versus vehicle), tubulointerstitial injury was largely confined to cyclosporine-treated rats on the -NaCl diet (P < 0.001 versus cyclosporine/+NaCl and vehicle). At 28 days after the withdrawal of cyclosporine, there was a marked discordance between renal structure and function in the cyclosporine/-NaCl group as GFR returned toward normal (P > 0.05 versus cyclosporine/+NaCl) but prominent tubulointerstitial injury persisted and, in some instances, even progressed (P < 0.001 versus cyclosporine/+NaCl and vehicle). Thus, sodium intake emerges as an important determinant of structural tubulointerstitial changes, whereas reductions in GFR during cyclosporine therapy are equivalent in sodium-depleted or sodium-replete animals.
The nursing role during end-of-life care in the intensive care unit related to the interaction between patient, family and professional: an integrative review.

AIM The aim of this study was to explore how intensive care unit (ICU) nurses describe their role during End-of-Life Care (EOLC) in the ICU, related to the interaction between patient, family and professionals (care triad). METHOD Three electronic databases, PubMed, CINAHL and EMBASE, and reference lists of included studies were searched for studies in English, Dutch or German between January 2002 and August 2015. Studies were included if they presented data about EOLC in the adult ICU, and the role of ICU nurses around EOLC. Quantitative and qualitative studies and opinion articles were extracted. Inductive content analysis was carried out to analyse and categorise the data. RESULTS Twenty studies were included. Four categories emerged: care for the ICU patient, care for the family, environmental aspects of EOLC and organisational aspects of EOLC. Regarding the care triad, a gap exists between theoretical models and the actual care provided by ICU nurses during EOLC. The relational aspect of care, like aimed with care triad, is absent. CONCLUSION The literature clearly indicates that the role of ICU nurses concerns care for the patient, family and environment. It described which care should be given, but it remains unclear how care should be given (attitude). Therefore, it is difficult for ICU nurses to provide this care. Further, it seems that care provided to family mainly consists of giving advice on how to care for the patient; care for family members themselves was only mentioned in a few studies. Therefore, it seems that family does not always receive adequate care yet, which may be helpful in preventing problems like depression, anxiety or post-traumatic stress disorder. It can be concluded that it is important for ICU nurses to be aware of the existing relationships; however, comparing the literature, care triad does not appear to be reached.
The Impact of Characteristics of Enterprise Information Systems on Business Performance: the cases of Taiwan companies

Abstract Despite growing interest and attention from researchers and practitioners in management studies, empirical research has been limited on how factors that influence an organization’s business performance are affected by certain characteristics of enterprise information systems (IS), such as maturity and infrastructure. This study reports on an empirical analysis of survey data to identify relationships among the informatization level, the business environment, and IS maturity and infrastructure related to business performance—based on financial and non-financial performance measurements—from the perspective of 136 Taiwan firms. The survey questionnaire respondents were drawn from individuals in each of these firms who were typically working in divisions related to business performance functions. Structural equation modeling was used to test the hypotheses that came from the research model in this study. Key Words : Information System(IS). Business Performance, Structural equation modeling
Water In The Arab World Perspectives And Prognoses

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