Miracle-dz/UniFAR-FTUs huggingface dataset:
Fractures in Geriatric Cases

Aim: Epidemiology of fractures in geriatric cases is little known and there are very few studies related with this issue. The aim of this study was to summarize the avail­able evidence on the frequency, gender, age, and seasonal distribution of fractures in geriatric cases. Material and Methods: Patients who were admitted to major trauma center because of extremity and spine problems were included in this study. Age, gender, type of fracture, treatment modality and seasonal distribution of fractures of all patients over 65 years of age were recorded and expressed in tables and graphs. Results: Between January 2016 and January 2018, 757 fractures were determined in geriatric patients who had complaints of extremity or spine pain. The incidence of fractures of the geriatric population was 39,5/1,000/year. The gender ratio of the fractures was 39/61(male/female). Fractures in geriatric cases were most commonly seen in femur (43.4%, 60% of them women), followed by radius (11.8%, 74% of them women) and humerus (10.6%, 70% of them women). Conclusions: Osteoporotic fractures are increasing in geriatric patients. Because of the higher incidence of morbidity and mortality, fractures in geriatric cases require multidisciplinary approach to their care.
RELIABILITY OF THE CORTICOTROPIN RELEASING HORMONE STIMULATION TEST FOR DIFFERENTIATING BETWEEN ACTH DEPENDENT AND INDEPENDENT CUSHING SYNDROME.

Context It is a challenge to determine the origin of Cushing syndrome (CS), especially in patients with low-normal adrenocorticotropic hormone (ACTH) concentrations. Objective To evaluate the reliability of the corticotropin-releasing hormone (CRH) stimulation test in patients with CS whose origin of disease was not clearly identified using ACTH values, the high-dose dexamethasone suppression test (HDDST), and imaging in a single tertiary referral center. Design and Methods Twenty-one patients with CS who were admitted to the endocrinology-metabolism clinic between 2004 and 2016 whose ACTH concentrations were 5-20 pg/mL and needed CRH stimulation test were retrospectively assessed. Results Nine out of 21 patients were diagnosed as having Cushing's disease (CD) and 12/21 had adrenal CS. The CRH stimulation test had a sensitivity and specificity of 100% and 8%, and positive and negative predictive values of 100% and 45% according to the current diagnostic criteria, respectively. An increase in ACTH ≥115% at 15 minutes and cortisol ≥86% at 60 minutes after CRH were associated with the highest likelihood ratio. The sensitivity and specificity of ACTH was 67% and 83% (AUC=0.75±0.12, 95% CI: [0.5-0.9]; p=0.03), and for cortisol it was 75% and 78% (AUC=0.71±0.15, 95% CI: [0.5-0.9]; p=0.03). Cortisol suppression of more than 64% from basal level in the HDDST suggested CD with the highest likelihood ratio. When these cut-off values were used together, both tests were negative in the patients with CD. Conclusion The CRH stimulation test has low specificity to localize CS in patients with ACTH concentrations of 5-20 pg/mL according to the current diagnostic criteria. Different diagnostic criteria may be used in the CRH stimulation test and also in the HDDST in this group of patients.
Echocardiographic global longitudinal strain is associated with infarct size assessed by cardiac magnetic resonance in acute myocardial infarction

The aim of this study was to investigate if there was an association between infarct size (IS) measured by cardiac magnetic resonance (CMR) and echocardiographic global longitudinal strain (GLS) in the early stage of acute myocardial infarction in patients with preserved left ventricular ejection fraction (LVEF). Patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention were assessed with CMR and transthoracic echocardiogram within 1 week of hospital admission. Two-dimensional speckle tracking was performed using a semi-automatic algorithm (EchoPac, GE Healthcare). Longitudinal strain curves were generated in a 17-segment model covering the entire left ventricular myocardium. GLS was calculated automatically. LVEF was measured by auto-LVEF in EchoPac. IS was measured by late gadolinium enhancement CMR in short-axis views covering the left ventricle. The study population consisted of 49 patients (age 60.4 ± 9.7 years; 92% male). The study population had preserved echocardiographic LVEF with a mean of 45.8 ± 8.7%. For each percent increase of IS, we found an impairment in GLS by 1.59% (95% CI 0.57–2.61), P = 0.02, after adjustment for sex, age and LVEF. No significant association between IS and echocardiographic LVEF was found: −0.25 (95% CI: −0.61 to 0.11), P = 0.51. At the segmental level, the strongest association between IS and longitudinal strain was found in the apical part of the LV: impairment of 1.69% (95% CI: 1.14–2.23), P < 0.001, for each percent increase in IS. In conclusion, GLS was significantly associated with IS in the early stage of acute myocardial infarction in patients with preserved LVEF, and this association was strongest in the apical part of the LV. No association between IS and LVEF was found.
The Fonthill Dental Surgery Complication Classification Scale

A lack of consensus on how to classify post‐operative complications in dentistry limits the ability for comparison of outcomes among treatments and their primary providers. Therefore, the Fonthill Dental Surgery Complication Classification Scale has been proposed as a uniform reporting tool to allow for the standardized quality assessment of dental treatment. This instrument classifies negative outcomes arising after dental treatment and is based on the clinician and the clinician time required to resolve the complication in seven classes of increasing severity.
Internal Protection of Transformer Windings Against Transeint Surges Using ZnO Varistors

Power system overvoltages due to switching, lightning and other disturbances are the main problem for designers of the power transformers. Once some frequencies of the incoming surges match with some of the natural frequencies of transformer winding, the resonance phenomenon is expected in transformer winding. The resonant overvoltages may destroy the insulation between turns and cause to insulation failure or transmformer damage. In this paper, the transformer winding is modeled based on the lattice diagram concept with variable parameters and the IEEE model of surge arresters has been utilized in order to perform the simulations. For internal protection of transformer windings, it is assumed that ZnO varistors are installed in parallel to the winding turns. Also the effect of ZnO varistors in reducing the voltage stress across the transformer winding has been investigated for the case of grounded and insolated nutral winding.
Influência do Índice de Massa Corporal na Sobrevida de Mulheres com Diferentes Subtipos de Câncer de Mama: uma Revisão Integrativa

Introdução: A obesidade é considerada fator prognóstico negativo para mulheres com câncer de mama; entretanto, sua influência sobre o curso da doença pode ser diferenciada nos subtipos moleculares. Objetivo: Analisar a influência do Índice de Massa Corporal (IMC) na sobrevida de mulheres com câncer de mama segundo o subtipo molecular. Método: Realizada revisão integrativa de literatura utilizando estratégia PICOS para formulação da pesquisa, identificação de palavras-chave e definição dos critérios de elegibilidade. Estudos que analisaram a influência do IMC na sobrevida de mulheres com câncer de mama, por subtipo tumoral, utilizando risco proporcional de COX e/ou Kaplan-Meier, publicados até junho de 2018, foram identificados nas bases PubMed, BVS, Scopus e Web of Science. Resultados: Foram selecionados 23 estudos entre 446 identificados. Mulheres com tumores do tipo triplo-negativo nas maiores categorias de IMC exibiram pior sobrevida em quatro dos 17 estudos incluindo esse subtipo. Nos casos de tumores luminal, IMC elevado foi fator prognóstico negativo em sete entre 11 estudos. Para HER2 (receptor tipo 2 do fator de crescimento epidérmico humano) superexpresso, houve pior sobrevida quando IMC elevado em dois dos seis estudos. Entre os HER2 positivos, independente do status hormonal, observou-se pior sobrevida para mulheres com maiores IMC em dois dos cinco estudos. Conclusão: O efeito do IMC na sobrevida de mulheres com câncer de mama parece ser diferenciado de acordo com o subtipo tumoral, sendo seu efeito, aparentemente, maior naquelas com tumores luminais.
The effect of intellectual capital on the performance of the National Development Fund

The aim of this study was to investigate the impact of the intellectual (human, structural, customer and innovation) capital on the National Development Fund’s performance. To achieve this goal, the statistical community was consisted of 160 management staffs of internal and external organization of National Development Fund. The findings suggest that aspects of the intellectual capital were significantly correlated with each other, and the independent variables, i.e. human, structural, customer, and innovation capitals affects the performance of the National Development Fund.
A way for reducing drug supply chain cost for a hospital district: A case study

Purpose: This work aims at providing insights to optimise healthcare logistic of the drug management, in order to deal with the healthcare expenditure cut. In this paper the effects of different drug supply chain configurations, on the resulting average stock, service level and Bullwhip effect, of the studied supply chain, is quantitatively assessed. Design/methodology/approach: A case study of an Italian district has been studied, taking into account three echelons: suppliers, central stock, and hospitals. A model of the various supply chain configurations has been created with the use of the simulation. Specifically, 24 supply chain configurations have been examined, stemming from the combination of several supply chain design parameters, namely: transshipment policies (Emergency Lateral Transshipment or Total Inventory Equalization); re-order and inventory management policies (Economic Order Quantity or Economic Order Interval); required service levels (90% or 95%); the number of available vans (one or two). For each configuration, hospital average stock, service level and a “Bullwhip effect” analysis are computed. To know which input variables are statistically significant, a DoE (Design of Experiments) analysis has been executed. Findings: The output of this paper provides useful insights and suggestions to optimize the healthcare logistic and drug supply chain. According to the developed DoE analysis, it can be stated that the introduction of transshipment policies provides important improvement in terms of service and stock levels. To reduce the Bullwhip effect, which results in a service level decreasing, and in a managing stock costs increasing, it is worth to adopt an EOQ re-order policy. Practical implications: This research gives practical recommendations to the studied system, in order to reduce costs and maintain a very satisfactory service level. Originality/value: This paper fulfils an identified need to study which combination of transshipment policies, re-order/inventory management policies and required service levels, can be the best one to reduce costs and maintain a very satisfactory service level, in the specific logistic system.
The efficacy and safety of anlotinib treatment for advanced lung cancer

Objective Anlotinib is an oral novel multi-target tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor, fibroblast growth factor receptor, platelet-derived growth factor receptor, and stem cell factor receptor (c-Kit). The aim of this study was to evaluate the efficacy and safety of anlotinib treatment in advanced lung cancer in the real world. Methods We evaluated the efficacy and toxicity of apatinib in patients with previously treated advanced lung cancer from 2018 to 2019 in Zhejiang Cancer Hospital. Survival analysis was performed by the Kaplan–Meier method. Results Fifty-eight patients were included in the present study. Thirty-one of these patients received anlotinib treatment as a third line and 27 patients received further therapy. All 58 patients had therapeutic evaluation and 46 patients acquired progression-free survival evaluation. Ten patients achieved partial response (PR), and 36 achieved stable disease (SD), representing a response rate of 17.2% and a disease control rate of 77.6%. Median progression-free survival was 3.3 months (95% CI 1.595–5.071). The toxicities associated with anlotinib were generally acceptable with a total grade 3/4 toxicity of 5.2%. The toxicities of anlotinib were generally tolerated and the common toxicities were hand–foot syndrome and hypertension. Conclusion In the third-line or more-line treatment of advanced lung cancer, anlotinib appears to have some activity when utilized as a salvage treatment. Adverse reactions are controllable.
Detection of inter-harmonics based on spectrum leakage

With the extensive application of a large number of nonlinear electrical components, harmonic and inter-harmonic components in power system become more and more complex. The harmonics, inter-harmonic and fundamental wave are in the superposition state. The traditional harmonic detection method is Fast Fourier Transform (FFT), which can realize the accurate detection and analysis of integer harmonics. But in the measurement of the harmonic,the actual signal detected should be by discretization using the sampling signal, which caused the phenomenon of spectrum leakage and fence phenomenon. However, since inter-harmonic is relatively small, the harmonic wave and fundamental wave become the noise of detecting inter-harmonic. These problems become a huge obstacle to the amplitude, frequency and phase of the accurate detection of inter-harmonic. In this paper, the spectrum leakage phenomenon is discussed.Based on the characteristics of the harmonic and fundamental wave, the improved algorithm is proposed. The method is based on simple transformation of Fast Fourier Transform (FFT) and combine respective characteristics of harmonics and inter-harmonic to solve the problem of measuring harmonic and inter-harmonic interference and achieve accurate detection of inter-harmonic. The method is effective in combination with the three point method, so it is more competitive with respect to other methods.The method has the advantages of simple operation, fast calculation and high accuracy, which can provide an effective method for the harmonic detection of power quality analysis.
Embryology, Epigenesis and Evolution: Taking Development Seriously

List of figures Preface 1. The problem of development 2. Exemplars 3. Scylla and Charybdis 4. Constitutive epigenetics 5. Creative development 6. A new synthesis? 7. The devil is in the Gestalt Endnotes Bibliography Index.
Top-down fabrication of plasmonic nanostructures for deterministic coupling to single quantum emitters

Metal nanostructures can be used to harvest and guide the emission of single photon emitters on-chip via surface plasmon polaritons. In order to develop and characterize photonic devices based on emitter-plasmon hybrid structures a deterministic and scalable fabrication method for such structures is desirable. Here we demonstrate deterministic and scalable top-down fabrication of metal wires onto preselected nitrogen vacancy centers in nanodiamonds using clean room nano-fabrication methods. We observe a life-time reduction of the emitter emission that is consistent with earlier proof-of-principle experiments that used non-deterministic fabrication methods. This result indicates that top-down fabrication is a promising technique for processing future devices featuring single photon emitters and plasmonic nanostructures.
Image analysis of Mitochondrial Texture in Progeria patients in response to shear stress and nuclear segmentation

In this paper, the effects of Hutchinson-Gilford progeria syndrome on endothelial cell’s mitochondrial response to shear stress will be discussed. I will also be addressing nuclear texture and differences in these same patient cells as compared to healthy cell lines. To accomplish this, I used cell culturing and fluorescent imaging techniques to gather images of cells to analyze the application of shear stress. I then used the Image Toolbox in Matlab to develop and implement a segmentation algorithm for these cells and ran analysis processes on them. Segmentation processes for the mitochondrial material and nuclear material were then developed. After segmentation, images were run though programs to perform Linear Optimal Transportation (LOT) analysis and some basic statistical tests. I found that after application of low shear stress for one hour, there was a spike in the amount of unhealthy mitochondria present. This returned to normal levels between one and six hours later. In the cells with the HGPS mutation, after the application of high shear stress, the mitochondria failed to recover and continued to show increases in the amount of unhealthy mitochondria. Differential clumping patterns of the unhealthy mitochondria were also observed in the HGPS cells as they gathered near the nucleus in larger clumps. Collectively, these results suggest that the endothelial cells of HGPS patients struggle to excrete the mitochondrial material.
The Effect of the Private Securities Litigation Reform Act of 1995 on Accounting Discretion of Client Managers of Big 6 and Non‐Big 6 Auditors

This study examines how the Private Securities Litigation Reform Act of 1995 (PSLRA) affects auditors' incentives to curtail earnings management by client managers. The most significant reform of PSLRA was the elimination of joint and several liability under which auditors and other parties could be named to lawsuits because of ‘deep pockets’ rather than culpability. While the elimination of joint and several liability provides significant relief to auditors from litigation, opponents of PSLRA argue that it discourages meritorious lawsuits and lowers audit quality, reducing investor confidence in markets. The potential benefit would be greatest for Big 6 firms, who have the highest exposure (largest clients) and significant resources to pay damages. In this paper we argue that if PSLRA induces decreases in audit quality, then we should expect increases in the prevalence of accruals after this Act. To investigate this issue we examine the discretionary accruals of a sample of 2,600 companies three years be.
DEVELOPMENT OF IMAGE SELECTION METHOD USING GRAPH CUTS

Abstract. 3D models have been widely used by spread of many available free-software. Additionally, enormous images can be easily acquired, and images are utilized for creating the 3D models recently. The creation of 3D models by using huge amount of images, however, takes a lot of time and effort, and then efficiency for 3D measurement are required. In the efficient strategy, the accuracy of the measurement is also required. This paper develops an image selection method based on network design that means surveying network construction. The proposed method uses image connectivity graph. The image connectivity graph consists of nodes and edges. The nodes correspond to images to be used. The edges connected between nodes represent image relationships with costs as accuracies of orientation elements. For the efficiency, the image connectivity graph should be constructed with smaller number of edges. Once the image connectivity graph is built, the image selection problem is regarded as combinatorial optimization problem and the graph cuts technique can be applied. In the process of 3D reconstruction, low quality images and similar images are also extracted and removed. Through the experiments, the significance of the proposed method is confirmed. It implies potential to efficient and accurate 3D measurement.
High-resolution shallow-seismic experiments in sand, Part I: Water table, fluid flow, and saturation

A high‐resolution, very shallow seismic reflection and refraction experiment was conducted to investigate the seismic response of groundwater level changes in beach sand in situ. A fixed 10-m-long receiver array was used for repeated seismic profiling. Direct measurements of water level in a monitoring well and moisture content in the sand were taken as well. The water table in the well changed by about 1 m in slightly delayed response to the nearby ocean tides. In contrast, inversion of the seismic data yielded a totally different picture. The reflection from the water table at high tide appeared at a later time than the reflection at low tide. This unexpected discrepancy can be reconciled using Gassmann’s equation: a low‐velocity layer must exist between the near‐surface dry sand and the deeper and much faster fully saturated sand. This low‐velocity layer coincides with the newly saturated zone and is caused by a combination of the sand’s high density (close to that of fully saturated sand), and its hig.
Asingle Phase Active Device for Power QualityImprovement of Electric Field Transportation

Problem statement: Now days, power quality has been given attention due to the intensive use of power electronic equipments in all types of industries such as steel, paper, textile industries and so on. These power electronic devices induce harmonic distortion into the supply lines which gives rise to many undesirable effects. Approach: This study presents a new method for harmonic and reactive power compensation with a Fuzzy logic controller and a new control algorithm for active power filter to eliminate harmonics and compensate the reactive power of three phase diode bridge rectifier with RL load. The Fuzzy logic controller was used to predict the reference current values and the firing pulses were generated using hysteresis current controller. The system was modeled and simulated using MATLAB/SIMULINK power system toolbox. Results: The total harmonic distortion for the system is reduced from 29.16-1.08% using the proposed fuzzy logic controller based shunt active filter. Conclusion: The simulation results found were quite satisfactory to eliminate harmonics and improve the power factor for non linearloads.
Effect of Carbamates Pesticide on Instar I-II larvae and Adult Artemia urumiana

The purpose of this assessment was to evaluate potential direct effects of acute and chronic toxicity of Maneb (Dithane-M22) and Carbaryl (Sevin) in Artimia urmiana. A study was conducted to determine the concentration incorporated in the contamination treatment of instar I-II larvae and Adult Artemia urumiana for 24 hr.and 48 hr. Nine-hundred Artemia urumiana were used in a 2 factorial experiments(time and concentration). Mortality was recorded during the different times as well as variable concentration.Acute intoxication of Maneb and Carbaryl were able to be induced at >33 ppm concentration, Carbaryl was more lethal than Maneb. Histopathological observations made from hematoxylin-eosin stained sections of Maneb and Carbaryl treated Artemia showed significant lesions which were found to be more extensive in Carbaryl treated Artemia than in those Maneb treated Artemia.Results of this study showed the potential of Carbaryl pesticide to cause serious damage of the nervous system of the Adult Artemia urumiana.On the other hand,Maneb pesticides was primarily highly toxic on instar I-II larvae