Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of preoperative training on postoperative depression in patients undergoing open heart surgery (2017)

Background:The prevalence of cardiovascular diseases among people in industrialized and developing countries are increasing. A look at recent WHO statistics suggests that these diseases account for 23% of global mortality rates, which make up a significant proportion in comparison with other causes of mortality. It is sate to be said that cardiovascular diseases cause problems for people and cause worries in the community, including lack of presence at work, high cost of surgery and drugs, disability and other cases. Evidence suggests that coronary artery disease is associated with anxiety and depression, sleep disorders, severe fatigue, and emotional complaints, since the body and mind are not separate.Objectives:By providing the necessary knowledge to patients, to a great extent, their mental problems can be prevented.Materials and Methods:This is an analytical study that evaluates the effect of preoperative training on depression in patients undergoing cardiac surgery in Shahid Modares Hospital. This study was performed on 80 patients undergoing cardiac surgery who were randomly divided into two groups of control and test. Before operation (surgery), the depression of the two groups was measured by Beck’s standard test. Then, the necessary training was given to the case (test) group. Then one month after the operation (surgery), the depression of the two groups was again measured and compared. The data collection tool was Beck’s standard test, which grading scale indicates 7-0, mild depression, 8-14, moderate depression, and 15-26, severe depression.Findings:The results of this study indicate that the training reduced the severe depression by 50% in the case group, but did not affect the mild to moderate depression. According to (p <0.001), there is a significant difference between depression two groups of control and case (test), and severe depression in the case group has been reduced by half. In addition, the research hypothesis was confirmed with 95% confidence. According to the above findings, it can be said that training not only reduces the physical problems of individuals, but also affects the mental and psychological problems of individuals.Conclusion:By communicating with patients and giving the necessary training in special wards, especially cardiac surgery, they can be more hopeful for their lives and their depression can be reduced and their recovery facilitated.
Sang subculture in post-reform China

This article examines Sang (丧) subculture within the context of positive energy (正能量) in post-reform China, and how as an emergent subculture it is characterised by feelings of defeatism and loss. Chinese youths share Sang memes via social media as a form of affective identification to communicate their sense of disenchantment with the ‘main melody’ of official discourse in post-reform China, and in this sense it is similar to other Internet cultures such as e’gao and diaosi. However, unlike subcultures in the West, Sang subculture does not constitute a form of political resistance, but expresses instead an inchoate feeling of loss among Chinese youths. This article asks two research questions: how does Sang subculture parody normative subject positions of youth constructed by official state discourse, and what does it reveal about the subjectivity of its participants? This article employs Raymond Williams’ concept of ‘structures of feeling’ within a semiotic framework to analyse three sets of Sang memes to understand the processes of subjectivity formation and the affective significance to its participants. Through semiotic analysis of Sang memes and semi-structured interviews with 20 participants aged between 18 and 26, we find that Sang subculture is a current of thought-feeling due to a perceived incapacity by Chinese youths to live up to the ideological re-positioning within official consciousness.
ANALISIS RISIKO ASET TI MENGGUNAKAN METODE OCTAVE PADA SWD RESTO

Rumah makan atau restoran merupakan salah satu jenis usaha yang sangat terbantu dengan adanya dukungan Teknologi Informasi/Sistem Informasi (TI/SI) dalam operasionalnya. Pengusaha rumah makan, baik yang belum ataupun yang telah memiliki cabang, sangat terbantu dengan penerapan TI/SI guna memantau kondisi dan kinerja perusahaan. SWD Resto adalah rumah makan yang berpusat di Surabaya dan telah memiliki cabang di luar pulau. SWD Resto menyajikan makanan di tempat dan menyediakan layanan take-out dining serta delivery service . Penerapan TI/SI pada SWD Resto bertujuan untuk meningkatkan pelayanan, ketepatan, kecepatan yang selaras dengan visi dan misi perusahaan. Aset TI yang dimiliki SWD Resto semakin bertambah sehingga perlu dilindungi dari risiko. Namun demikian, aset TI yang dimiliki belum dikelolah dengan baik. Penelitian ini bertujuan untuk melakukan analisis risiko TI pada SWD Resto menggunakan metode OCTAVE ( Operationally Critical Threat, Asset, and Vulnerability Evaluation ). Pengumpulan data dilakukan melalui observasi, wawancara dan pengisian kuisioner. Hasil penelitian berupa dokumentasi identifikasi aset kritis yang terdapat pada SWD Resto pusat dan cabang beserta ancaman, kerentanan dan pendekatan mitigasi pada setiap aset kritis. Kata Kunci : analisis r isik o , aset TI, OCTAV E
Rucaparib for the treatment of ovarian cancer

ABSTRACT Introduction: Poly adenosine diphosphate-ribose polymerase (PARP) inhibitors (PARPi) are evolving as one of the most promising therapies in ovarian cancers, especially for patients with a BRCA1/2 or Homologous Recombination Repair (HRR) defect. Rucaparib is one of the three PARPi approved for use in ovarian cancer. Recent research has opened an expanded indication for PARPi beyond germline BRCA1/2 (gBRCA1/2) mutation. This increases the number of patients eligible for PARPi from around 15–20% of high grade serous ovarian cancers (HGSOC) with BRCA1/2 mutations to around 50%. Areas covered: This review focuses on Rucaparib, its pharmacology and salient preclinical and clinical data. The significance of a companion diagnostic test, which helps in selection of patients for Rucaparib, the upcoming trials, future directions and challenges are also discussed. Expert opinion: In germline or somatic BRCA1/2 (g/sBRCA1/2) mutated ovarian cancer patients, Rucaparib is found to have a tolerable side effect profile and improves the progression free survival. A companion diagnostic test by Foundation Medicine’s which looks at the genomic scarring, may help refine patients who would maximally benefit from Rucaparib, but is not sensitive or specific enough to categorically identify which patients will not benefit from Rucaparib. Rucaparib is an important therapeutic option for women with ovarian cancer.
Mycotoxins in Children’s Food: Problem and Halal Management

Mycotoxins are ubiquitous compounds found in the natural life cycle of food- producing plants. They have a range of diverse chemical and physical properties and toxicological effects on man and animal. Mycotoxins are considered the most important contaminants of the food chain due to their chronic adverse effects on health and the economy. Mycotoxins are known as the 21th century “Great Masquerader” due to its complex natural history involving different tissues and resembling different diseases at each stage in its evolution. Mycotoxins can induce a variety of clinical symptoms including epistaxis, conjunctivitis, coughing, apnea, wheezing, vomiting and nausea. Some mycotoxins induce acute pulmonary hemorrhage, bone marrow failure and pneumonia. Knowledge about these symptoms enables the clinician to ask questions for possible exposure to the main classes of mycotoxins to protect children from sources of such exposure. These sources may include food, clothes, furniture and indoor air at home. Early childhood exposure to mycotoxins may be critical determinants of later health effects. Exposure in utero and through early infancy may additionally be important. Several well-known diseases such as neural tube defects, liver and esophageal cancers are associated with the consumption of mycotoxin-contaminated food. Knowledge of previous short or long term exposure to mycotoxins may help paediatricians to more accurately diagnose and provide treatment options to children and their families. The current review discusses the problems associated with the occurrence of different common mycotoxins in children’s food and the possible halal strategies to counteract these problems.
Symptome der Angst und Depression bei Patienten mit oraler gerinnungshemmender Therapie und deren Angehörigen

Hintergrund: Die Einnahme eines Vitamin-K-Antagonisten (VKA) erfordert ein umfangreiches Selbstmanagement des Pa- tienten, um eine effektive Therapie zu erzielen. Die orale gerinnungshemmende Therapie befindet sich im Spannungsfeld der Uber- und Unterdosierung und unterliegt zahlreichen Einflussfaktoren. Nahestehende Angehorige ubernehmen eine wichtige unterstutzende Funktion in der Sicherstellung der medikamentosen Behandlung im Langzeitverlauf. Das Ziel dieser deskriptiven Studie war das Belastungsempfinden von Patienten mit oraler VKA-Therapie und deren Angehorigen zu erfassen. Methodik: In einer Querschnittstudie wurden Patienten mit einer VKA-Therapie und deren Angehorige im Akutsetting eines Krankenhauses mit dem Selbstbeurteilungsbogen der „Hospital Anxiety and Depression Scale“ (HADS-D) befragt. Ergebnisse: Von den 56 Patienten wiesen 30,4% (n=17) behandlungsbedurftige Symptome der Angst und 25% (n=14) Symp- tome der Depression in der HADS-D auf. Bei den Angehorigen (n=11) zeigten 18,2% (n=2) auffallige Symptome der Angst, die Symptome der Depression waren unauffallig in der HADS-D. Bei den Patienten gab es eine Tendenz zu einem Zusammenhang zwischen der Blutungskomplikation "Blut im Stuhl" (p<0,06) und auffalligen Werten in der Subskala Angst. Die Variable „Blut im Urin“ (p<0,06) wies eine Tendenz zu einem Zusammenhang mit auffalligen Werten in der Subskala Depression fur die Patienten auf. Bei den Angehorigen konnten keine signifikanten Einfluss- faktoren auf die Phanomene Angst und Depression identifiziert werden. Diskussion: Die vorliegenden Ergebnisse stellen eine erste Annaherung dar, in welchen Situationen bei VKA-Therapie Symp- tome der Angst und Depression verstarkt auftreten konnen. Tritt eine Komplikation ein, so kann dies mit psychischen Belastungen im Selbstmanagement des Patienten verknupft sein.
FINE STRUCTURAL ASPECTS OF THE EFFECT OF CALCIUM INFLUX INDUCED BY A23187 ON THE CULTURED THYROID GLANDS OF RATS

Effects of calcium influx induced by ionophore A2318? on incubated thyroids were studied in their ultrastructural aspects. The follicle epithelial cells showed strong reactions to thyroid stimulating hormone (TSH), such as phagocytotic uptake of luminal colloid and the formation of intracellular colloid droplets, even when the calcium ions were absent from the medium. On the other hand, no morphological responses were recognized in the follicle epithelial cells incubated in the medium containing A23l87 (0.15 mM) and CaCl2 (2.5 mM), but not TSH, though degranulations by exocytosis are usually seen in the mast cells of the interfollicular connective tissue. These findings suggest that the stimulation effect of TSH on the thyroid follicle epithelial cell is not influenced by the absence of extracellular calcium ions, and that calcium influx does not stimulate the secretory activity of this cell if TSH is absent from the medium. This study was planned to clarify the effect of calcium influx on the fine structure of thyroid follicle cells. Antibiotic A23l87, which is extracted from cultures of Srreptomyces charrreusensis, is a carboxylic ionophore which can transport calcium across the plasma membrane (21, 22, 24). It is believed that intracellular calcium plays an important role in the release of the secretory materials from the glandular cells. Douglas and Rubin (6, 7), who demonstrated that the influx of calcium into the chromaffm cells promotes the release of catecholamine, proposed a concept of ‘stimulus-secretion coupling’. Since then, numerous papers have been published on the positive effects of calcium ion on the release of the secretory substances from various kinds of tissues, for instance, the adrenal medulla (3, 4), exocrine pancreas (17), mast cells (10, 16, 18), salivary gland (23), neurohypophysis (5, 25), leukocytes (20, 26), carotid body (14), juxtaglomerular cells (15), macrophages (12), and anterior pituitary (11, 19). It has also been reported that the secretory activities of the parathyroid gland (1) and of the adrenal cortex (9) are rather suppressed by this calcium ionophore. Almost all these informations are based on the results of biochemical or physiological studies. The ultrastructural aspects of the effect of A2318? on secretory cells have as yet received little attention. Since thyroxine (T4) and triiodothyronine (T3) are not peptide but amino-acid derivatives, consisting of only two molecules of iodotyrosine, the secretory mechanisms of thyroid follicle cells are different from those of the secretory cells mentioned above. In the hyperfunctional stage of the epithelial cell of the thyroid follicle, which is induced by thyroid stimulating hormone (TSH), the lurninal colloid is reabsorbed into the cell by endocytosis and hydrolyzed to liberate T3 and T4, which are released from the basal part of the cell into the interfollicular connective tissue. Thus the effect of calcium influx on the
FREEZING OF GAIT IN PARKINSON'S DISEASE: IMPACT ON FALLS RISK, WALKING AIDS UTILIZATION, AND ASSISTANCE-SEEKING BEHAVIOUR

Freezing of Gait (FOG) is one of the most disturbing symptoms in advanced stage of Parkinson’s disease (PD) that is strongly associated with recurrent falls and reduced functional independence. The purpose of the study was to determine the impact of FOG on mobility in terms of risk of falls, walking aids utilization and assistance-seeking behaviour by comparing freezers (FRs) and nonfreezers (NFRs). Clinical and demographic data, including disease duration, stage and characteristics, cognition, edication, history of falls, walking aids utilization, and assistanceseeking behaviour was collected from 102 subjects with PD from three medical centres in Belgium, Israel, and UK. Association between FOG and other disease characteristics, medication, falls, walking aids, and need for carers’ assistance was investigated. Comparing FRs and NFRs showed significant difference in history of previous falls, walking aids utilization, and need for carers’ assistance. More than half of the FRs reported previous fall and a need for walking aids for mobility compared to 20% in NFRs group. A vicious cycle exists among subjects with PD who experience FOG. Gait freezing induces increased risk and frequency of falls as well as increased fear of falling, which in turn increases the tendency towards higher reliance on carers’ assistance and more utilization of walking aids.
A Rare Case of Systemic Lupus Erythematosus with Gastric Antral Vascular Ectasia

SYSTEMIC LUPUS ERYTHEMATOSUS is an autoimmune disease associated with auto antibody production. The inflammation produced by it can affect and damage many organ systems. The involvement of gastrointestinal system in SLE is well documented. The extent of involvement of git and the frequency of symptoms is being underestimated. Patients present with vague complaints such as abdominal pain, nausea, upper GI bleed with non-specific physical examination findings and inconclusive diagnostic tests and serologic analysis. In SLE diagnosis should be evoked, when clinical picture and endoscopic features are suggestive to present as upper GI bleed like peptic ulcer diease, gastric vascular ectasia
Comparison of Three Compensation Methods for the Touch-trigger Probe Pretravel Errors

On-machine inspection (OMI) system has been used extensively for automatic setting of the workpiece and determination of kinematic error in machine tool. There is a necessity not only for knowledge of touch-trigger probing error characteristic, but also for the compensation method of probe error because probing error is an important component of system errors. The comparison of compensation accuracy of three compensation methods is presented. To compensate the touch trigger probe pre-travel errors the calibration experiments with a reference sphere are conducted. Subsequently, the calibration data are used in three compensation methods that the bilinear interpolation method, the bicubic Coons pitch interpolation method and the neural network method. Finally, the validate experiments are conducted on the OMI system, and the compensation results show that the bicubic Coons pitch interpolation method is the most accuracy compensation method.
#Opinionleaders: a comparison of self-reported and observable influence of Twitter users

ABSTRACT Social media have become forums of discussions on political and societal debates in which individual users may forward information or influence others. While prior studies either employed network analyses or surveys to identify opinion leaders and their characteristics, the present investigation combines these two approaches to address the relationship between observable and self-perceived influence. For this purpose, a retweet network of Twitter communication on the Brexit debate (N = 15,018) was analyzed in relation to a survey on motives and personality traits that was filled out by a subsample of active users (N = 98). Results showed that users’ eigenvector centrality (as a measure of influence in the network) was significantly related to their political interest and their number of followers, but not to self-perceived opinion leadership. According to a comparison of self-assessment and network position, those with stronger motivations to distribute relevant information tended to overestimate their influence in the network. Implications for the identification of opinion leaders are discussed.
The renin-angiotensin system as a primary cause in the pathophysiology of polyarteritis nodosa

Polyarteritis nodosa is a necrotizing vasculitis of medium-sized arteries of unknown origin. Hypertension is present in 30% of patients with polyarteritis nodosa. In those cases, high renin levels are thought to be secondary to renal involvement. The present study was performed to identify causal factors of polyarteritis nodosa. In cyp1a1ren-2 transgenic rats, vasculitis of medium-sized arteries resembling classical polyarteritis nodosa can be induced. In this model, oral administration of indole-3-carbinol (I3C) activates the liver-specific cyp1a1 promoter, leading to prorenin expression in a dose-dependent manner. After the first 6 weeks of chronic induction with 0.125% I3C, the mean arterial pressure reached a plateau of about 170 mmHg. Ten out of 11 I3C-treated rats, which were chronically instrumented with a telemetric device to measure blood pressure, developed polyarteritis nodosa within 10 weeks of I3C treatment. I3C alone or instrumentation alone did not cause polyarteritis nodosa. The angiotensin-converting enzyme inhibitor captopril completely prevented the development of polyarteritis nodosa, indicating that local angiotensin II generation is a pathogenetic factor in this model. The renin–angiotensin system can play a primary role in the development of polyarteritis nodosa in rats.
Isotope Constraints on the Sources of Particulate Organic Carbon in a Subtropical Deep Reservoir

Reservoirs are active sites in the terrestrial environment in terms of carbon transformation and storage. Continuous reservoir construction reinforces the importance of such artificial storage; however, knowledge pertaining to the sources, cycling, and preservation of autochthonous/allochthonous particulate organic carbon (POC) in reservoirs remains incomplete. We monitored the flux and carbon isotope composition of sinking particles in a subtropical deep reservoir, and the results were compared with the isotopic signatures of potential POC sources (soil) and the sedimentary sink. We found that the typhoon‐induced POC flux was transported laterally at intermediate water depths within the reservoir and that it contributed more than 70% of the annual deposition. An isotope ternary mixing model showed that over 87% of the POC preserved in sediments was allochthonous. Although the autochthonous POC from primary production was preferentially degraded, the preserved autochthonous POC (42 ± 14 gC m−2 yr−1) was comparable to the observed carbon dioxide uptake (35 gC m−2 yr−1) by the reservoir, suggesting a high efficiency of carbon preservation in subtropical deep reservoirs.
Evaluation of Glenohumeral Rheumatoid Arthritis: Classification, Reliability, and Impact on Surgical Management

To date, no published data exist confirming the reliability of the Neer, Levigne, or Miyoshi classifications for glenohumeral wear patterns in rheumatoid arthritis. We examined the intraobserver and interobserver agreement of these systems to determine which is most reliable. Four orthopedic surgeons with fellowship training in upper extremity disorders and 4 orthopedic trainees examined 53 radiographs of rheumatoid shoulders and classified them according to the 3 radiographic schemes. After a minimum 2-week interval, each observer repeated the classification process. The Levigne classification demonstrated good intraobserver (&kgr;=0.80) and interobserver agreement (&kgr;=0.64); the Neer classification, good intraobserver (&kgr;=0.61) and moderate interobserver agreement (&kgr;=0.50); and the Miyoshi classification, good intraobserver (&kgr;=0.66) and fair interobserver agreement (&kgr;=0.37). There were no differences in intraobserver reliability between trainees and fellowship-trained physicians. Although all systems demonstrated reasonable overall reliability, these data suggest that the Levigne system may be most reliable for classification of rheumatoid arthritis affecting the glenohumeral joint. Level of training did not impact the ability of observers to reliably judge rheumatoid wear patterns with these classification systems.
The Future Use of Medicinal Plants as Alternatives to Antibiotics in Animal Health and Production

The health and animal health experts all over the world are very concern about the widespread of antibacterial resistance which happens when bacteria genetically change following over use and misuse of antibiotics. The use of antibiotics as growth promotors to enhance animal production is banned in many countries around the world where organic production is being encouraged. In USA, the use of sub-therapeutic doses in animal feed and/or water to promote growth and improve feed efficiency was eliminated effective January 1, 2017, as a result of new FDA Veterinary Feed Directive [1].