Miracle-dz/UniFAR-FTUs huggingface dataset:
Ventrally emigrating neural tube (VENT) cells: a second neural tube‐derived cell population

Two embryological fates for cells of the neural tube are well established. Cells from the dorsal part of the developing neural tube emigrate and become neural crest cells, which in turn contribute to the development of the peripheral nervous system and a variety of non‐neural structures. Other neural tube cells form the neurons and glial cells of the central nervous system (CNS). This has led to the neural crest being treated as the sole neural tube‐derived emigrating cell population, with the remaining neural tube cells assumed to be restricted to forming the CNS. However, this restriction has not been tested fully. Our investigations of chick, quail and duck embryos utilizing a variety of different labelling techniques (DiI, LacZ, GFP and quail chimera) demonstrate the existence of a second neural tube‐derived emigrating cell population. These cells originate from the ventral part of the cranial neural tube, emigrate at the exit/entry site of the cranial nerves, migrate in association with the nerves and populate their target tissues. On the basis of its site of origin and route of migration we have named this cell population the ventrally emigrating neural tube (VENT) cells. VENT cells also differ from neural crest cells in that they emigrate considerably after the emigration of neural crest cells, and lack expression of the neural crest cell antigen HNK‐1. VENT cells are multipotent, differentiating into cell types belonging to all four basic tissues in the body: the nerve, muscle, connective and epithelium. Thus, the neural tube provides at least two cell populations – neural crest and VENT cells – that contribute to the development of the peripheral nervous system and various non‐neural structures. This review describes the origin of the idea of VENT cells, and discusses evidence for their existence and subsequent fates.
Under-utilisation of organic wastes during brownfield regeneration to community woodland: Tackling the barriers

The regeneration of brownfield land to greenspace is a governmental policy objective of many European countries. Healthy vegetation establishment and growth is an essential component of successful greenspace establishment, and research has shown that a planting medium of an appropriate standard for supporting vegetation can be created through amendment of soil-forming materials with organic wastes. However, failed regeneration projects suggest that barriers may exist that prevent the use of suitable quality soil materials. The aim of this research was to identify barriers to the use of organic wastes for improving soil materials for brownfield regeneration to community woodland. We conducted interviews with a range of professionals experienced in regeneration to greenspace, and used content analysis on interview transcripts. A diverse set of barriers was revealed, including a low technical awareness among some professional groups of how to improve soil quality, coupled with a low awareness of the published technical guidance. Other barriers include regulatory and project management issues, which influence the timings and economics of raising brownfield soil quality. We highlight areas in which future efforts may be focused to improve the quality of planting media used in land regeneration. Such effort will improve the sustainability of greenspaces created and complement effective management of organic waste streams.
$M$-DCSK-Based Chaotic Communications in MIMO Multipath Channels With No Channel State Information

We consider chaotic digital communications in multiple-input-multiple-output (MIMO) wireless multipath fading channels. In particular, we focus on systems that employ M -ary differential chaos shift keying (M-DCSK). We consider two transceiver schemes, both of which require no channel state information at either the transmitter or the receiver. The first one employs a distinct chaotic sequence at each transmit antenna to spread the same data symbol and transmits omnidirectionally. At each receive antenna, the corresponding differential detection statistic is formed, and these statistics are then combined with equal gain for symbol detection. The second scheme employs a single chaotic spreading sequence and makes use of adaptive transmit and receive beamforming. The beamformers are updated by using a simple stochastic gradient method that is based on the received signal power and a finite-rate feedback strategy. Simulation results show that both schemes can effectively exploit the spatial diversity of the underlying MIMO system, and the adaptive beamforming scheme significantly outperforms the omnidirectional transmission.
Green supplier selection via Multiple Criteria Data Envelopment Analysis

Purpose – The purpose of this paper is to develop a slack-based measure (SBM) model in the presence of dual-role factor. Then it is applied in supplier selection problem. Design/methodology/approach – The developed model in this paper is based on data envelopment analysis (DEA) technique. Findings – The proposed evaluation platform is capable of identifying ill-performing suppliers which seek to future improvement. The findings provide valuable insights for practitioners, as well as academicians, policy makers and also integrate selection criteria under the supply chain. Originality/value – This is the first time that a non-radial DEA model considers dual-role factors. The proposed model does not deal with dual-role factor as a non-discretionary factor. The proposed model considers dual-role factors on both the input and output sides in a similar manner. The proposed model can fully measure the inefficiency of suppliers. The proposed model can give a complete ranking of suppliers.
NF-kappaB activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells.

Cytokine stimulation can activate NF-kappaB that triggers inducible expression of E-selectin, VCAM-1 (Vascular Cell Adhesion Molecule-1) and ICAM-1 (Intercellular Cell Adhesion Molecule-1) in endothelial cells. In the previous study, we have shown that B lymphocytes and plasma cells can express E-selectin by constitutive activation of NF-kappaB. Here we show that human B lymphocytes and ARH-77 plasma cells expressed VCAM-1 and ICAM-1 in a cytokine dispensable mechanism. NF-kappaB antagonists could inhibit their expressions in ARH-77 cells. The activities of NF-kappaB for VCAM-1 and ICAM-1 promoters prior to cytokine stimulation were detected in ARH-77 cells using electrophoretic mobility shift assays. Again, NF-kappaB antagonists could abrogate these promoter activities. Taken together, our results demonstrate that NF-kappaB activation is the underlying molecular mechanism for constitutive expression of E-selectin, VCAM-1, and ICAM-1 on human B lymphocytes and plasma cells.
Reflections on the Establishment of Performance Assessment Index System of Patent Strategy

Patent is the most important part of intelligent property.The implementation of patent strategy should be measured with a standard.With this purpose,it establishes a performance assessment index system of patent strategy,and probes into the principles of establishing the index system,data collection and calculation,classification and framework of the system,index interpretation and data source.It aims to provide a reference for monitoring and evaluating the patent strategy.
Fabrication and Characterization of High-Quality Factor GaN-Based Resonant-Cavity Blue Light-Emitting Diodes

High-quality factor (Q >; 1700) GaN-based blue resonant-cavity light-emitting diodes (RCLEDs) incorporating an InGaN/GaN multiquantum well active region, two high-reflectivity dielectric-distributed Bragg reflectors, and a thin indium tin oxide (ITO) layer are fabricated by a two-step substrate transfer technique. Electroluminescence measurements showed a narrow linewidth of 0.26 nm at the wavelength of 450.6 nm by precisely placing the ITO layer at the node position of the electric field, corresponding to a high Q-value of 1720. Further, adopting a chemical-mechanical polishing (CMP) technique to polish the GaN surface after the removal of sapphire substrate, an even higher Q-value of 2170 was obtained. This improvement was attributed to the exclusion of the defect-rich buffer layer and the achievement of a smooth surface with a root mean square roughness below 1 nm. The integrated electroluminescence intensity was enhanced by 40% as compared with the RCLEDs without CMP at a current density of 8 kA/cm2.
Dose-response assessment for developmental toxicity. II. Comparison of generic benchmark dose estimates with no observed adverse effect levels.

Developmental toxicity risk assessment currently relies on the estimation of reference doses (RfDDTS) of reference concentrations (RfCDTS) based on the use of no observed adverse effect levels (NOAELS) divided by uncertainty factors (UFs). The benchmark dose (BMD) has been proposed as an alternative basis for reference value calculations. A large database of 246 developmental toxicity experiments representing 1825 endpoints related to dead implants or malformed fetuses has been compiled for use in evaluating alternative approaches to developmental toxicity risk assessment. Using this database we have compared two approaches for BMD estimation with each other and with corresponding statistically derived NOAELS. Comparisons have been based on proportion of affected litters (litters with one or more affected offspring, a quantal response variable) and on the proportion of affected offspring within each litter (a continuous response variable). A quantal Weibull model was used to calculate generic BMDs for the quantal response variable (QBMDs) and a continuous power model was used to calculate generic BMDs for the continuous response variable (CBMDs) at three levels of additional risk (10, 5, and 1%). CBMD05s (continuous benchmark doses for 5% risk) and CNOAELs (statistically derived NOAELs based on the continuous response variable) were similar, with over 98% of the data subsets having CBMD05 and CNOAEL values that differed by less than an order of magnitude. In contrast, QNOAELs tended to be greater than corresponding QBMD10s. The observed conservatism of the QBMD values relative to the corresponding CBMD values was attributed to two factors, lower maximum likelihood estimates for the quantal model and wider confidence intervals around the maximum likelihood estimates, compared to the continuous model. (ABSTRACT TRUNCATED AT 250 WORDS)
The Credibility of Hong Kong's Currency Board System: Looking Through the Prism of MS‐VAR Models with Time‐Varying Transition Probabilities

​This paper takes seriously the idea that the coefficients of a VAR and the variance of shocks may be time-varying and so employs a Markov regime-switching VAR model to describe and analyse the time-varying credibility of Hong Kong’s currency board system. The endogenously estimated discrete regime shifts are made dependent on macroeconomic fundamentals. This enables us to determine which changes in macroeconomic variables can trigger switches between the low and high credibility regimes. We carry out extensive testing to search for the most appropriate specification of the Markov regime-switching model. We find strong evidence of regime switching behaviour that portrays the timevarying nature of credibility in the historical data. Our own conditional volatility index provides anticipatory signals and amplifies the regime-switching transition probabilities. Publication keywords: Markov regime-switching VAR, exchange rate regime credibility, Hong Kong
A Di-acidic (DXE) Code Directs Concentration of Cargo during Export from the Endoplasmic Reticulum*

Efficient export of vesicular stomatitis virus glycoprotein (VSV-G), a type I transmembrane protein, from the endoplasmic reticulum requires a di-acidic code (DXE) located in the cytosolic carboxyl-terminal tail (Nishimura, N., and Balch, W. E. (1997) Science 277, 556–558). Mutation of the DXE code by mutation to AXA did not prevent VSV-G recruitment to pre-budding complexes formed in the presence of the activated form of the Sar1 and the Sec23/24 complex, components of the COPII budding machinery. However, the signal was required at a subsequent concentration step preceding vesicle fission. By using green fluorescence protein-tagged VSV-G to image movement in a single cell, we found that VSV-G lacking the DXE code fails to be concentrated into COPII vesicles. As a result, the normal 5–10-fold increase in the steady-state concentration of VSV-G in downstream pre-Golgi intermediates and Golgi compartments was lost. These results demonstrate for the first time that inactivation of the DXE signal uncouples early cargo selection steps from concentration into COPII vesicles. We propose that two sequential steps are required for efficient export from the endoplasmic reticulum.
The Impact of IV Fat Emulsion Administration in Acute Lung Injury.

The aim of this study was to evaluate the effect of parenteral nutrition containing medium- and long-chain triglycerides on the function of the respiratory system and to investigate mechanisms involved in this process. We studied 13 patients with acute respiratory distress syndrome (ARDS), 8 receiving lipid and 5 placebo, and 6 without ARDS, receiving lipid. Bronchoalveolar lavage (BAL) was performed before and 1 hour after administration of lipid or placebo. In patients with ARDS, lipid administration resulted in deterioration of oxygenation (PaO2/FIO2: from 129 ± 37 to 95 ± 42), compliance of respiratory system (from 39.2 ± 12 to 33.1 ± 9.2 mL/cm H2O), and pulmonary vascular resistance (from 258 ± 47 to 321 ± 58 dyne·s·cm-5). In the BAL fluid of the same group, an increase in total protein and phospholipid concentrations, phospholipase activities, platelet-activating factor and neutrophils, and alterations in BAL lipid profile were observed. No significant changes were observed in the control or in the ARDS-Placebo groups. In conclusion, this study indicates that administration of medium- and long-chain triglycerides in patients with ARDS causes alterations in lung function and hemodynamics. Inflammatory cells, possibly activated by lipids, release phospholipase A2 and platelet-activating factor, enhancing edema formation, inflammation, and surfactant alterations.
Sodium Taurocholate Cotransporting Polypeptide Acts as a Receptor for Hepatitis B and D Virus

Infection of hepatitis B virus (HBV) remains a major public health problem worldwide. Understanding the viral infection and developing antivirals against HBV have been hampered by the lack of convenient culture systems and animal models for the infection. Sodium taurocholate cotransporting polypeptide (NTCP), a key bile acid transporter expressed in liver, was recently identified as a critical receptor for viral entry of HBV and its satellite virus hepatitis D virus (HDV). This finding enabled a reliable cell culture system for the viruses. Detailed studies have shown that NTCP is the major determinant for the species specificity of HBV and HDV at entry level. NTCP is responsible for most sodium-dependent bile salt uptake in liver. The molecular determinant critical for HBV/HDV infection overlaps with that for bile acids transporting on NTCP. We evaluated bile acids as potential antivirals for HBV and HDV infection, and developed bile acid derivatives that effectively block taurocholate transporting as well as viral infections. The discovery that NTCP acts as a receptor for HBV has opens a new door for future studies towards the ultimate goal of curative treatment of HBV infection.
Advances in the analysis of complex food matrices: Species identification in surimi-based products using Next Generation Sequencing technologies

The Next Generation Sequencing (NGS) technologies represent a turning point in the food inspection field, particularly for species identification in matrices composed of a blend of two or more species. In this study NGS technologies were applied by testing the usefulness of the Ion Torrent Personal Genome Machine (PGM) in seafood traceability. Sixteen commercial surimi samples produced both in EU and non-EU countries were analysed. Libraries were prepared using a universal primer pair able to amplify a short 16SrRNA fragment from a wide range of fish and cephalopod species. The mislabelling rate of the samples was also evaluated. Overall, DNA from 13 families, 19 genera and 16 species of fish, and from 3 families, 3 genera and 3 species of cephalopods was found with the analysis. Samples produced in non-EU countries exhibited a higher variability in their composition. 37.5% of the surimi products were found to be mislabelled. Among them, 25% voluntary declared a species different from those identified and 25% (all produced in non-EU countries) did not report the presence of molluscs on the label, posing a potential health threat for allergic consumers. The use of vulnerable species was also proved. Although the protocol should be further optimized, PGM platform proved to be a useful tool for the analysis of complex, highly processed products.
The relationship of high school teachers' job satisfaction to principal support

The purpose of this study was to examine the relationship between high school teacher job satisfactio~ using an instrument that measures Herzberg's Two Factor Theory and principal support, using an adapted instrument from House's theory of administrative support. Data were collected by a team of researchers from 34 self-selected public Virginia high schools and consisted of 1276 teacher participants. Correlation and regression analyses were performed to find the relationship between teacher job satisfaction and principal support. The results showed no significant relationship between principal support and high school teacher job satisfaction. This may be explained in part by the weakness of the Professional Job Satisfaction Survey (PJSS). The data on the Principal Support Scale (PSS) revealed two distinct factors of principal support that related back to House's original theory of administrative support (DiPaola, in press). A significant positive correlation was found between the expressive and instrumental dimensions of principal support (r = .796, p < .01). A significant negative correlation was found between job satisfiers and job dissatisfiers (r = .421, p < .05). Based on these fmdings future researchers should continue to explore this topic with a more reliable measurement of job satisfaction. Future researchers should continue to explore the relevance of Herzberg's two factor theory in education and examine the effect of external forces on both job satisfaction and principal support. Continued use of the PSS for measuring principal support in relationships with other school social variables is also strongly supported by this study.
Rat-Race Circuits with Loose Coupling Using Parallel Ring-Lines

This paper treats a rat-race circuit with loose coupling using parallel ring-lines. The minimum coupling factor of a conventional rat-race circuit is limited by the highest impedance of ring-lines that can be manufactured. The proposed rat-race circuits with parallel ring-lines can be realized couplers with loose coupling factors of less than -10 dB by reducing the difference between two admittances of parallel ring-lines. The circuit with a coupling factor of -20 dB can be successfully designed. Finally, verification of this design method can be also shown by using electromagnetic simulator and experiment.
Mycosporine and mycosporine-like amino acids: A paramount tool against ultra violet irradiation

Various facts demonstrated that UVB is harmful to organisms. Sunscreen compounds are usually used to prevent the excessive damage caused by UVB. However, certain photosynthetic organisms have evolved mechanisms to counteract the toxicity of ultraviolet radiation by synthesizing UV screening compounds such as mycosporine-like amino acids (MAAs). MAAs provide UV protection to primary and secondary consumers through food chain and to non-biological materials by photostabilizing action. Information related to the ecological consequence of MAAs and their spatial distribution from a wide range of organisms is accumulating. Hence, our studies seek a potent class of natural sun protective compounds to understand their relationship with environment and to develop a protocol for large-scale industrial production of these compounds so that they can find application as UV-protecting cosmetics.
Memory Complaints Are Frequent but Qualitatively Different in Young and Elderly Healthy People

Background: Subjective memory complaints are frequently reported by the elderly. There is less information about the characterization of subjective memory complaints in young people. Objective: To determine different memory complaints between young and elderly people with the use of the Subjective Memory Complaints (SMC) scale. Methods: Participants were volunteers attending a health itinerant unit, a blood donor centre, a leisure centre for retired people, a senior citizens college or university. All participants were questioned about their own memory abilities using the SMC scale and assessed for the presence of depressive symptoms. Results: Nine-hundred and forty-six subjects aged 18–92 years were included in the study. The mean total score on the SMC scale was 4.89 ± 3.03, and 75.9% of the participants had at least minor complaints about their memory. Older people had more general memory complaints and reported they were more likely to become transiently confused, whereas younger people reported they were more frequently told by others that they were forgetful and would more often take notes. Conclusions: Memory complaints were frequent both in young and elderly subjects, but the detailed assessment revealed age-related differences in the type of complaints.
Interprofessional anatomy education in the United Kingdom and Ireland: Perspectives from students and teachers

There is increasing recognition of multiprofessional learning in anatomy and its role in medical and healthcare professions. This study utilized two components to investigate anatomy interprofessional education (AIPE) in the United Kingdom and Ireland. First, a survey involving qualitative and quantitative components asked Heads of Anatomy to report on their institutions’ uptake of AIPE. Second, a series of case studies explored the experiences of students by using evaluation forms and an in‐depth analysis of thematic concepts to understand the learners’ perspectives on designing and delivering AIPE. Out of the 13 institutions that took part in the survey, eight did not offer an AIPE program. Between the remaining five institutions that deliver AIPE programs, 10 different modules are offered with the majority involving healthcare professions. The AIPE component is rated highly by students. The themes from the case studies highlight how valuable AIPE is from the student perspective both in terms of engaging them in anatomy as well as in the broader skills of teamwork and communication. The case studies also revealed how AIPE can be engaging for groups of students who might not have previously had access to cadaveric anatomy, for example, engineers and archeologists. The results of this study have implications for curriculum design in medicine and healthcare but also for further engagement of professional groups from non‐healthcare backgrounds. Anat Sci Educ 8:360–370. © 2015 American Association of Anatomists.