Miracle-dz/UniFAR-FTUs huggingface dataset:
The Analysis of Business Leadership Model: A Case Study

In this research, we employed the business leadership model as the core form Driving Strategy into Action based on Harvard Business Review. We attempt to explore strategic management models that are developed from this foundation and how the discrepancy between a company's current situation and its goals drives the organization to be flexible in employing a set of strategic execution formulas. Analysis performed under the structure of the business leadership model divides the concept of strategy into strategic intent, marketplace insight, innovation focus, and business design; the concept of execution is divided into talent, formal organization, critical task, climate and culture. We will include exploring the topic of strategic management theory and the difference in applied models used by the case study company and also look at actual examples from the case study company and explore how they used the business leadership model to bring about internal adjustments in strategy when faced with gaps in performance. we plan to conduct in-depth interviews with supervisors of relevant departments who have decision-making authority in the case company. Our major goal is to confirm the models that were applied and how they were actually able to help the company achieve competitive advantages. (Der-Juinn Horng, Yih-Chearng Shiue, Chi-Ming Wu, Chen-Ping Liu, Shih-Chun Chen. The Analysis of Business Leadership Model: A Case Study. Life Sci J 2013; 10(2):2706-2713). (ISSN: 1097-8135). http://www. lifesciencesite.com 377
Mathematical Model of Errors of Odometry and Georeferencing Channels in Visual Correlation Extreme Navigation

The mathematic model of errors in correlation with the extreme navigation system (CENS) is developed basing on odometry and geo-referencing channels. The realization of the model is done in Simulink, and based on regular and random components of additive noise. The results of simulations prove accumulation of errors for odometry errors and its mitigation in case of geo-referencing in periods of correction.
Comment from the Editor on the Special Issue “Head and Neck Critical Illness: Basic and Clinical Research Implications”

While oncogenic mutations of head and neck squamous cell carcinomas (HNSCC) in head and neck malignancies are uncommon, analysis using next-generation sequencing (NGS) technologies is growing. Further, single-cell analysis is being developed to overcome cancer cell heterogeneity and improve the poor survival of patients. However, it is important for researchers to know how to use this information to improve patients’ survival.
Dietary Intake of Branched-Chain Amino Acids and Risk of Colorectal Cancer

Branched-chain amino acids (BCAA) are essential amino acids, and emerging evidence suggests that BCAAs may mediate pathways related to cancer progression, possibly due to their involvement in insulin metabolism. We investigated the association between dietary intake of BCAAs with colorectal cancer risk in three prospective cohorts: the Nurses' Health Study I [(NHS), number of participants (n) at baseline = 77,017], NHS II (n = 92,984), and the Health Professionals Follow-up Study [(HPFS) n = 47,255]. Validated food frequency questionnaires were administered every 4 years and follow-up questionnaires on lifestyle biennially. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox proportional hazards regression models. Pooled HRs were obtained using random effect models. After up to 28 years of follow-up, 1,660 cases were observed in NHS, 306 in NHS II, and 1,343 in HPFS. In multivariable adjusted models, we observed a weak inverse association between BCAA intake and colorectal cancer [highest vs. lowest quintile, pooled HR including all three cohorts (95% CI): 0.89 (0.80–1.00), Ptrend = 0.06, HR per standard deviation (SD) increment 0.95 (0.92–0.99)]. However, after including dairy calcium to the models, BCAA intake was no longer associated with risk of colorectal cancer [HR 0.96 (0.85–1.08), Ptrend = 0.50, HR per SD increment 0.97 (0.93–1.01)]. We did not find evidence that higher dietary BCAA intake is associated with higher risk of colorectal cancer. As this is the first prospective study to examine the association between BCAA intake and colorectal cancer, our findings warrant investigation in other cohorts.
Who experiences depressive symptoms following mindfulness-based stress reduction and why?

Background: A small percentage of patients screen positive for depression following a mindfulness-based program. We identified patient characteristics associated with this outcome in order to understand this phenomenon.Methods: Depressive symptoms, stress, mindfulness, coping with illness and sense of coherence were measured in 126 patients with various medical and psychological conditions pre- and post- Mindfulness-Based Stress Reduction (MBSR). Results: Fewer patients (27% vs. 49%) screened positive for depression post-MBSR. Both pre- and post-MBSR patients who were depressive following MBSR scored lower on meaningfulness, comprehensibility, and manageability (sense of coherence), higher on emotional coping and lower on palliative and distraction coping. Smaller positive changes (e.g. stress) occurred in these patients as well. Viewing life as less meaningful pre-MBSR predicted more symptoms of depression post-MBSR.Conclusions: Patients who suffered depressive symptoms following the program were unable to reappraise their lives in such a way as to become stress resilient.
Slower Walking Speed Is Related to Early Femoral Trochlear Cartilage Degradation After ACL Reconstruction

Post‐traumatic patellofemoral osteoarthritis (OA) is prevalent after anterior cruciate ligament reconstruction (ACLR) and early cartilage degradation may be especially common in the femoral trochlear cartilage. Determining the presence of and factors associated with early femoral trochlear cartilage degradation, a precursor to OA, is a critical preliminary step in identifying those at risk for patellofemoral OA development and designing interventions to combat the disease. Early cartilage degradation can be detected using quantitative magnetic resonance imaging measures, such as tissue T2 relaxation time. The purposes of this study were to (i) compare involved (ACLR) versus uninvolved (contralateral) femoral trochlear cartilage T2 relaxation times 6 months after ACLR, and (ii) determine the relationship between walking speed and walking mechanics 3 months after ACLR and femoral trochlear cartilage T2 relaxation times 6 months after ACLR. Twenty‐six individuals (age 23 ± 7 years) after primary, unilateral ACLR participated in detailed motion analyses 3.3 ± 0.6 months after ACLR and quantitative magnetic resonance imaging 6.3 ± 0.5 months after ACLR. There were no limb differences in femoral trochlear cartilage T2 relaxation times. Slower walking speed was related to higher (worse) femoral trochlear cartilage T2 relaxation times in the involved limb (Pearson's r: −0.583, p = 0.002) and greater interlimb differences in trochlear T2 relaxation times (Pearson's r: −0.349, p = 0.080). Walking mechanics were weakly related to trochlear T2 relaxation times. Statement of clinical significance: Slower walking speed was by far the strongest predictor of worse femoral trochlear cartilage health, suggesting slow walking speed may be an early clinical indicator of future patellofemoral OA after ACLR. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:645–652, 2020
Chorionic and amniotic placental membrane‐derived stem cells, from gestational diabetic women, have distinct insulin secreting cell differentiation capacities

Women with gestational diabetes mellitus (GDM), and their offspring, are at high risk of developing type 2 diabetes. Chorionic (CMSCs) and amniotic mesenchymal stem cells (AMSCs) derived from placental membranes provide a source of autologous stem cells for potential diabetes therapy. We established an approach for the CMSC/AMSC‐based generation of functional insulin‐producing cells (IPCs). CMSCs/AMSCs displayed significantly elevated levels of NANOG and OCT4 versus bone marrow‐derived MSCs, indicating a potentially broad differentiation capacity. Exposure of Healthy‐ and GDM‐CMSCs/AMSCs to long‐term high‐glucose culture resulted in significant declines in viability accompanied by elevation, markedly so in GDM‐CMSCs/AMSCs, of senescence/stress markers. Short‐term high‐glucose culture promoted pancreatic transcription factor expression when coupled to a 16‐day step‐wise differentiation protocol; activin A, retinoic acid, epidermal growth factor, glucagon‐like peptide‐1 and other chemical components, generated functional IPCs from both Healthy‐ and GDM‐CMSCs. Healthy‐/GDM‐AMSCs displayed betacellulin‐sensitive insulin expression, which was not secreted upon glucose challenge. The pathophysiological state accompanying GDM may cause irreversible impairment to endogenous AMSCs; however, GDM‐CMSCs possess comparable therapeutic potential with Healthy‐CMSCs and can be effectively reprogrammed into insulin‐secreting cells.
SUNSHINE HOURS VARIABILITY AND ITS RESPONSE TO AEROSOLS IN LAGOS STATE NIGERIA

This paper analyses the variability of sunshine hours for an equatorial region of Lagos (06°35' N, 03°19' E) Nigeria. It is found that the total sunshine hours has seasonal variability which maximizes in April and minimizes in July. Unlike a decreasing trend in sunshine hours found in some countries the sunshine hours in Lagos the busiest city in Nigeria is found to be increasing at a rate of 0.0449hrs/yr for a period of nine years. The paper investigates the possibly effects of Aerosols on the variability of the sunshine hours using Aerosol Index from Earth Probe TOMS (Total Ozone Mapping Spectrometer) Version.8.
Place, the Built Environment, and Means Restriction in Suicide Prevention

Restricting access to lethal means is a key public health intervention for preventing suicide. Means restriction research has often focused on suicide methods that are modifiable through legislation or policy interventions. However, some of the most common methods such as hanging may not be sensitive to regulation. The aims of this paper are to examine built environment and place-based approaches to means restriction in suicide prevention, and further consider the connections between place, the environment, and suicide methods. To increase knowledge about specific methods and mechanisms of injury in suicide deaths, higher resolution data for surveillance and epidemiology is required. Data that can be used to better discern patterns about specific locations and materials used in suicide and self-harm will support efforts to uncover new directions for prevention.
I wanted it as soon as possible: a qualitative exploration of reactions to access to same-day ART start among participants in San Diego’s ART-NET project

ABSTRACT Rapid start of antiretroviral therapy (ART) is quickly becoming best practice around the world. In the US, programs exist to facilitate rapid ART start, but little is known about the experiences of newly diagnosed individuals receiving these recommendations and services. Twenty participants (19 men who have sex with men and 1 transgender woman) from an early ART start program were interviewed to better understand these experiences. Interviews were analyzed for main themes in three general areas: reasons to start, reasons to delay, and factors influencing early ART adherence. Participants reported starting anywhere from right away (same visit as diagnosis) to within a few weeks (median 10.5 days). Reasons to start right away included fear of what could happen if not treated, personal health, influence of people/resources at the clinic, and study participation. Most had small delays in ART start because of structural (insurance, costs) and intentional delays (getting additional medical consultations). Adherence facilitators included desires to improve CD4/viral load and positive beliefs in benefits of suppression. Participants were largely supportive of rapid ART start and appeared to rely on CD4/viral load as “proof” of need for ART, which may be particularly helpful for asymptomatic, newly diagnosed individuals starting ART.
Implementation of sliding mode observer based reconfiguration in an autonomous underwater vehicle

This paper looks at the implementation of a Sliding Mode Observer (SMO) based Reconfiguration algorithm to deal with sensor faults within the context of navigation controllers for Autonomous Underwater Vehicle (AUV). In this paper the reconfigurability aspects are considered for the heading controller. Simulation responses are used to illustrate that the Sliding Mode Observer is able to give state information to the controller when there is a fault in the AUV’s sensor package. Comparisons are made between the Sliding Mode Controller with and without reconfigurability for a number of different sensor failures, e.g. bias errors in or the complete loss of the heading data, and the robustness of the Sliding Mode Observer is investigated through the introduction of disturbances into the system.
Antibacterial activity of free or encapsulated selected phenylpropanoids against Escherichia coli and Staphylococcus epidermidis

Antibacterial activities of phenylpropenes (PPs) (eugenol, isoeugenol, estragole and trans‐anethole) and hydroxycinnamic acids (HCAs) (p‐coumaric, caffeic and ferulic acids) were assessed against Escherichia coli and Staphylococcus epidermidis. Effect of cyclodextrin and liposome encapsulation on the PPs activity was also evaluated.
Pollen season is reflected on symptom load for grass and birch pollen‐induced allergic rhinitis in different geographic areas—An EAACI Task Force Report

The effectiveness of allergen immunotherapy (AIT) in seasonal and perennial allergic rhinitis (AR) depends on the definition of pollen exposure intensity or time period. We recently evaluated pollen and symptom data from Germany to examine the new definitions of the European Academy of Allergy and Clinical Immunology (EAACI) on pollen season and peak pollen period start and end. Now, we aim to confirm the feasibility of these definitions to properly mirror symptom loads for grass and birch pollen‐induced allergic rhinitis in other European geographical areas such as Austria, Finland and France, and therefore their suitability for AIT and clinical practice support.
Microphthalmos-anophthalmos-coloboma (MAC) spectrum in two brothers with Renpenning syndrome due to a truncating mutation in the polyglutamine tract binding protein 1 (PQBP1) gene

ABSTRACT Background: Patients with intellectual disability syndromes frequently have coexisting abnormalities of ocular structures and the visual pathway system. The microphthalmos, anophthalmos, and coloboma (MAC) spectrum represent structural developmental eye defects that occur as part of a syndrome in one-third of cases. Ophthalmic examination may provide important diagnostic clues in identifying these syndromes. Purpose: To provide a detailed and comprehensive description of the microphthalmos, anophthalmos, and coloboma (MAC) spectrum in two brothers with intellectual disability and dysmorphism. Methods: The two brothers underwent a detailed ophthalmic and systemic evaluation. A family pedigree was obtained and exome sequencing was performed in the proband. Results: The two brothers aged 4 and 7 years had intellectual disability, microcephaly, short stature, and characteristic dysmorphic features. Ophthalmic evaluation revealed the presence of the MAC spectrum in both boys. Genetic testing led to the detection of an X-linked hemizygous truncating mutation in the nuclear polyglutamine-binding protein 1 (PQBP1) gene confirming the diagnosis of X-linked recessive Renpenning syndrome. Conclusion: The presence of X-linked intellectual disability and characteristic dysmorphism, in a patient with the MAC spectrum should raise the suspicion of Renpenning syndrome. PQBP1 mutation testing is confirmatory. A comprehensive systemic evaluation is mandatory in all patients with the MAC spectrum and intellectual disability.
Etaher, Najla and Weir, George R. S. and Alazab, Mamoun (2015) From ZeuS to Zitmo : trends in banking malware. In: Proceedings - 14th IEEE International Conference on Trust, Security and Privacy in Computing

In the crimeware world, financial botnets are a global threat to banking organizations. Such malware purposely performs financial fraud and steals critical information from clients’ computers. A common example of banking malware is the ZeuS botnet. Recently, variants of this malware have targeted mobile platforms, as The-ZeuS-in-the-Mobile or Zitmo. With the rise in mobile systems, platform security is becoming a major concern across the mobile world, with rising incidence of compromising Android devices. In similar vein, there have been mobile botnet attacks on iPhones, Blackberry and Symbian devices. In this setting, we report on trends and developments of ZeuS and its variants.
Revisit Rescula and Cystoid Macular Edema and Refractory Glaucoma

Rescula (unoprostone isopropyl) has been in the market as ocular hypotensive drug since 1994. There are amounting scientific research and post-marketing clinical experiences reported in peer review journals. Yet there seems limited understanding about its unique clinical implication associated with newly discovered molecular mechanism (traits) of BK channel activation. Hence this review article is using a focal lens with an eye on B-K channel activation to further delineate possible roles of rescula in modulating chronic parainflammation in the eye, which may eventually set it apart from the rest lipid hypotensive drugs such as latanoprost that is pro-inflammatory in nature. Cystoid macular edema and refractory glaucoma will be the key historical clinical case highlights.
VEGFR-1 Regulates EGF-R to Promote Proliferation in Colon Cancer Cells

The relationship between epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) pathways in tumor growth is well established. EGF induces VEGF production in cancer cells, and the paracrine VEGF activates vascular endothelial cells to promote tumor angiogenesis and thus supports tumor cell growth in an angiogenesis-dependent manner. In this study, we found angiogenesis-independent novel crosstalk between the VEGF and the EGF pathways in the regulation of colon cancer cell proliferation. Stimulation of colon cancer cells with VEGF-A and placental growth factor (PlGF) activated VEGF receptor-1 (VEGFR-1) and increased proliferation activity in an autocrine EGF/EGF receptor (EGF-R)-dependent manner. Mechanistically, VEGFR-1 interacted with and stabilized EGF-R, leading to increased EGF-R protein levels and prolonged its expression on cell surface plasma membrane. In contrast, VEGFR-1 blockade by a neutralizing antibody and an antagonistic peptide of VEGFR-1 suppressed the complex formation of VEGFR-1 and EGF-R and decreased EGF-R expression via a lysosome-dependent pathway, resulting in the suppression of proliferation activity. Our results indicated that VEGFR-1 regulated EGF-R expression to promote proliferation activity in a cell-autonomous-dependent manner.
Is molecular gas necessary for star formation

On galactic scales, the surface density of star formation appears to be well correlated with the surface density of molecular gas. This has led many authors to suggest that there exists a causal relationship between the chemical state of the gas and its ability to form stars – in other words, the assumption that the gas must be molecular before star formation can occur. We test this hypothesis by modelling star formation within a dense cloud of gas with properties similar to a small molecular cloud using a series of different models of the chemistry, ranging from one in which the formation of molecules is not followed and the gas is assumed to remain atomic throughout, to one that tracks the formation of both H2 and CO. We find that the presence of molecules in the gas has little effect on the ability of the gas to form stars: star formation can occur just as easily in atomic gas as in molecular gas. At low densities (<104 cm−3), the gas is able to cool via C+ fine-structure emission almost as efficiently as via CO rotational line emission, while at higher densities, the main cooling process involves the transfer of energy from gas to dust, meaning that the presence of molecules is again unimportant. Cooling by H2 is particularly inefficient, accounting for as little as 1 per cent of the overall cooling in the cloud. Rather than the chemical makeup, we find that the most important factor controlling the rate of star formation is the ability of the gas to shield itself from the interstellar radiation field. As this is also a prerequisite for the survival of molecules within the gas, our results support a picture in which molecule formation and the formation of cold gas are both correlated with the column density of the cloud – and thus its ability to shield itself – rather than being directly correlated with each other.
Mining Sub-Interval Relationships In Time Series Data

Time-series data is being increasingly collected and stud- ied in several areas such as neuroscience, climate science, transportation, and social media. Discovery of complex patterns of relationships between individual time-series, using data-driven approaches can improve our understanding of real-world systems. While traditional approaches typically study relationships between two entire time series, many interesting relationships in real-world applications exist in small sub-intervals of time while remaining absent or feeble during other sub-intervals. In this paper, we define the notion of a sub-interval relationship (SIR) to capture inter- actions between two time series that are prominent only in certain sub-intervals of time. We propose a novel and efficient approach to find most interesting SIR in a pair of time series. We evaluate our proposed approach on two real-world datasets from climate science and neuroscience domain and demonstrated the scalability and computational efficiency of our proposed approach. We further evaluated our discovered SIRs based on a randomization based procedure. Our results indicated the existence of several such relationships that are statistically significant, some of which were also found to have physical interpretation.