Miracle-dz/UniFAR-FTUs huggingface dataset:
MODELE D'INTERFACE ENDOMMAGEABLE POUR LES ASSEMBLAGES COLLES

Resume : Les collages sont de plus en plus employes dans l’industrie. Le manque d’outils numeriques fiables et efficaces pour la prediction de la capacite de charge de ce type d’assemblage limite encore leur application. Le modele d’interface endommageable propose par L. Champaney et N. Valoroso permet la modelisation de la degradation du collage pendant toute la phase de chargement. Ce modele a ete implante dans le code de calcul industriel CAST3M. La difficulte, en utilisant ce type de modele, est justement l’identification des parametres mecaniques de l’interface. L’un des objectifs du travail realise est l’identification de ces parametres. Cette identification est basee sur des mesures acoustiques non destructives des caracteristiques initiales du collage (raideurs) et sur des mesures mecaniques destructives (energies critiques). L’objectif final de cette etude est d’avoir un outil numerique capable d’apporter la fiabilite et l’efficacite dont l’industrie a besoin pour developper davantage l’utilisation du collage comme methode d’assemblage structural.
The addictive process in unusual addictions: a further elaboration of etiology.

Addiction is more precisely comprehended by understanding the personality of the addict rather than the chemical or physiological properties of the addicting agent. The addict has a unique relationship with his chosen addicting substance; without this agent he cannot deal with the stressful factors in his life. The authors present case reports of patients addicted to nose drops and water. This was a form of unsuccessful self-treatment in which the addicts used an external mechanism of defense to solve their problems.
MRI-compatible optically-sensed cello

An opto-acoustic cello has been designed to investigate the neural correlates of cello performance using functional magnetic resonance imaging (MRI). Through the design of specialized optical sensors, for the first time, we are able to synchronously capture a cellist's acoustic performance and musical gestures within the MRI scanner. The electromagnetic constraints and confined space of the scanner were overcome through the design of a minimalist composite cello body, a bridge and transparent fingerboard embedded with optical fibers, and a sensorized shortened bow. Using an array of fibers embedded in the fingerboard, we captured finger position and vibrato. Bending losses in fibers placed between the bridge and string, as a contact microphone, allowed us to capture the acoustic performance. Bow displacement was acquired separately using an optical flow sensor and by measuring Faraday rotation in an optical crystal within the magnetic field of the scanner.
Pulse-Shaping With Digital, Electrical, and Optical Filters—A Comparison

We investigate the performance of sinc-shaped QPSK signal pulses generated in the digital, electrical, and optical domains. To this end an advanced transmitter with a digital pulse-shaper is compared to analog transmitters relying on pulse-shaping with electrical and optical filters, respectively. The signal quality is assessed within a single carrier setup as well as within an ultra-densely spaced WDM arrangement comprising three channels. An advanced receiver providing additional digital filtering with an adaptive equalization algorithm to approximate an ideal brick-wall Nyquist filter has been used for all schemes. It is found that at lower symbol rates, where digital processing is still feasible, digital filters with a large number of filter coefficients provide the best performance. However, transmitters equipped with only electrical or optical pulse-shapers already outperform transmitters sending plain unshaped NRZ signals, so that for higher symbol rates analog electrical and optical techniques not only save costs, but are the only adequate solution.
Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage.

Cleavage of V(D)J recombination signals by purified RAG1 and RAG2 proteins permits the dissection of DNA structure and sequence requirements. The two recognition elements of a signal (nonamer and heptamer) are used differently, and their cooperation depends on correct helical phasing. The nonamer is most important for initial binding, while efficient nicking and hairpin formation require the heptamer sequence. Both nicking and hairpin formation are remarkably tolerant of variations in DNA structure. Certain flanking sequences inhibit hairpin formation, but this can be bypassed by base unpairing, and even a completely single‐stranded signal sequence is well utilized. We suggest that DNA unpairing around the signal‐coding border is essential for the initiation of V(D)J combination.
Impact of multidisciplinary, early renal education on vascular access placement.

BACKGROUND The Ochsner Clinic Foundation initiated the Healthy Start Clinic to identify, educate, and refer chronic kidney disease patients to nephrologists earlier in the course of their disease. This study investigated the impact of a structured educational session on the type and timing of permanent vascular access placement in patients receiving hemodialysis. METHODS Before initiating dialysis, the HSC patient group received a general overview of the kidney and kidney disease, plus one-on-one instruction from a registered nurse, a dietitian, and a social worker. The HSC group was compared with a concurrent, conventionally prepared group of CKD patients who initiated dialysis during the same study period. RESULTS Of the 147 patients initiating hemodialysis at OCF between April 1997 and December 2000, 61 had received structured HSC education, and 86 had received conventional care. In HSC-educated patients, the incidence of PVAs placed before hemodialysis initiation was twofold greater than in patients who received conventional care (77% HSC; 36% non-HSC, p < 0.001), and more HSC-educated patients initiated hemodialysis using their PVA (49% HSC; 23% non-HSC, p < 0.01). In addition, five times more patients who received HSC education received arteriovenous fistulas (52% HSC; 10% non-HSC, p < 0.001). Finally, significantly fewer HSC-educated patients initiated dialysis on a temporary catheter (51% HSC; 77% non-HSC, p < 0.001). CONCLUSIONS Education programs for CKD patients help increase the number of patients receiving early PVA placement, as well as the proportion of patients receiving AVFs as opposed to grafts or temporary catheters.
Output-feedback tracking control for a class of nonlinear non-minimum phase systems via dynamic surface control

In this paper, we investigate the output tracking control problem for a class of nonlinear non-minimum phase systems via output-feedback. The method of output redefinition is applied to let the stability of the internal dynamics which is originally unstable depend on that of redefined output, thus we only need to consider the new external dynamics rather than internal dynamics in the process of designing control law. To conquer the derivation explosion problem in traditional backstepping design, the dynamic surface control (DSC) method is firstly utilized to handle the problem of tracking control for the nonlinear non-minimum phase systems. The proposed output-feedback DSC controller drives the system output to track desired trajectory asymptotically, and simutanneously forces the unstable internal dynamics to track its corresponding causal and bounded ideal internal dynamics, which is computed via the stable system center method. The validity of the proposed controller is verified via a numerical simulation.
Determination of Human Myosin III as a Motor Protein Having a Protein Kinase Activity*

The class III myosin is the most divergent member of the myosin superfamily, having a domain with homology to a protein kinase. However, the function of class III myosin at a molecular level is not known at all, and it has been questioned whether it is actually an actin-based motor molecule. Here, we showed that human myosin III has an ATPase activity that is significantly activated by actin (20-fold) with Kactin of 112 μm and Vmax of 0.34 s–1, indicating the mechanoenzymatic activity of myosin III. Furthermore, we found that human myosin III has actin translocating activity (0.11 ± 0.05 μm/s) using an in vitro actin gliding assay, and it moves toward the plus end of actin filaments. Myosin III containing calmodulin as the light chain subunit showed a protein kinase activity and underwent autophosphorylation. The autophosphorylation was the intramolecular process, and the sites were at the C-terminal end of the motor domain. Autophosphorylation significantly activated the kinase activity, although it did not affect the ATPase activity. The present study is the first report that clearly demonstrates that the class III myosin is an actin-based motor protein having a protein kinase activity.
Validación de una estrategia de detección y tratamiento sistemático de la bacteriuria asintomática en portadores de trasplante renal

Introduccion: La infeccion del tracto urinario (sintomatica o asintomatica (BA)) es la infeccion bacteriana mas comun en pacientes con trasplante renal (TxR). La deteccion y tratamiento sistematico de la bacteriuria asintomatica en este grupo de pacientes es controvertida. El objetivo del presente trabajo es validar una estrategia de deteccion y tratamiento de BA en receptores de trasplante renal. Material y metodos: Cohorte retrospectiva de pacientes con TxR, que`presentaron BA y recibieron tratamiento y pacientes que no presentaron BA. Se realizaron los siguientes analisis estadisticos: estadistica descriptiva basica, analisis bivariantes de las variables dependientes objeto de estudio contra las variables independientes estudiadas segun la naturaleza de las mismas, analisis de medidas repetidas para el estudio de la funcion del injerto renal durante tres anos despues del trasplante renal. Resultados: Se incluyeron 189 pacientes trasplantados renales, 75 (39,68%) mujeres y 114 (60,32%) varones, con una media de edad de 49 anos. De los 189 pacientes que componen la cohorte 96 presentaron BA y 93 no. El analisis de frecuencia mostro que los pacientes que presentaron BA tuvieron mas riesgo relativo (RR) de ITU sintomatica, (RR= 1,28 Intervalo de confianza (IC)= 1,06 a 1,54 p= 0,002), ITU persistente (RR: 1,21 IC: 1,06 a 1,38 p= 0,0001) y PNF (RR: 1,11 IC: 1,01 a 1,22 y p= 0,005). La evolucion de la funcion del injerto renal durante los tres anos posteriores al trasplante, en pacientes que presentaron BA y recibieron tratamiento y en aquellos que no desarrollaron BA no mostro diferencias significativas (p>0,05). El estudio de los factores asociados al desarrollo de rechazo agudo y PNF mostro que la presencia de mas de cinco episodios de BA se asocio significativamente con el desarrollo de rechazo (p<0,03) y la presencia de dos o mas episodios de BA, glomerulonefritis como enfermeda que motivo el trasplante, enfermedad por citomegalovirus y presencia de al menos un episodio de rechazo agudo se asociaron significativamente con el desarrollo de PNF (p <0,05) mientras el trasplante simple de rinon resulto ser un factor protector (OR: 0,193 IC:0,052-0,712 p=0,0135). Conclusiones. Los sujetos con trasplante renal con BA detectada y tratada de manera sistematica tienen una evolucion de la funcion renal del injerto a medio plazo similar a la de aquellos sujetos que no presentaron BA. La estrategia de deteccion y tratamiento sistematico de la BA es insuficiente para prevenir el desarrollo de PNF.
Exercise and type 2 diabetes mellitus: changes in tissue-specific fat distribution and cardiac function.

PURPOSE To prospectively assess the effects of an exercise intervention on organ-specific fat accumulation and cardiac function in type 2 diabetes mellitus. MATERIALS AND METHODS Written informed consent was obtained from all participants, and the study protocol was approved by the medical ethics committee. The study followed 12 patients with type 2 diabetes mellitus (seven men; mean age, 46 years ± 2 [standard error]) before and after 6 months of moderate-intensity exercise, followed by a high-altitude trekking expedition with exercise of long duration. Abdominal, epicardial, and paracardial fat volume were measured by using magnetic resonance (MR) imaging. Cardiac function was quantified with cardiac MR, and images were analyzed by a researcher who was supervised by a senior researcher (4 and 21 years of respective experience in cardiac MR). Hepatic, myocardial, and intramyocellular triglyceride (TG) content relative to water were measured with proton MR spectroscopy at 1.5 and 7 T. Two-tailed paired t tests were used for statistical analysis. RESULTS Exercise reduced visceral abdominal fat volume from 348 mL ± 57 to 219 mL ± 33 (P < .01), and subcutaneous abdominal fat volume remained unchanged (P = .9). Exercise decreased hepatic TG content from 6.8% ± 2.3 to 4.6% ± 1.6 (P < .01) and paracardial fat volume from 4.6 mL ± 0.9 to 3.7 mL ± 0.8 (P = .02). Exercise did not change epicardial fat volume (P = .9), myocardial TG content (P = .9), intramyocellular lipid content (P = .3), or cardiac function (P = .5). CONCLUSION A 6-month exercise intervention in type 2 diabetes mellitus decreased hepatic TG content and visceral abdominal and paracardial fat volume, which are associated with increased cardiovascular risk, but cardiac function was unaffected. Tissue-specific exercise-induced changes in body fat distribution in type 2 diabetes mellitus were demonstrated in this study.
Antibiotic-induced dysbiosis alters host-bacterial interactions and leads to colonic sensory and motor changes in mice

Alterations in the composition of the commensal microbiota (dysbiosis) seem to be a pathogenic component of functional gastrointestinal disorders, mainly irritable bowel syndrome (IBS), and might participate in the secretomotor and sensory alterations observed in these patients.We determined if a state antibiotics-induced intestinal dysbiosis is able to modify colonic pain-related and motor responses and characterized the neuro-immune mechanisms implicated in mice. A 2-week antibiotics treatment induced a colonic dysbiosis (increments in Bacteroides spp, Clostridium coccoides and Lactobacillus spp and reduction in Bifidobacterium spp). Bacterial adherence was not affected. Dysbiosis was associated with increased levels of secretory-IgA, up-regulation of the antimicrobial lectin RegIIIγ, and toll-like receptors (TLR) 4 and 7 and down-regulation of the antimicrobial-peptide Resistin-Like Molecule-β and TLR5. Dysbiotic mice showed less goblet cells, without changes in the thickness of the mucus layer. Neither macroscopical nor microscopical signs of inflammation were observed. In dysbiotic mice, expression of the cannabinoid receptor 2 was up-regulated, while the cannabinoid 1 and the mu-opioid receptors were down-regulated. In antibiotic-treated mice, visceral pain-related responses elicited by intraperitoneal acetic acid or intracolonic capsaicin were significantly attenuated. Colonic contractility was enhanced during dysbiosis. Intestinal dysbiosis induce changes in the innate intestinal immune system and modulate the expression of pain-related sensory systems, an effect associated with a reduction in visceral pain-related responses. Commensal microbiota modulates gut neuro-immune sensory systems, leading to functional changes, at least as it relates to viscerosensitivity. Similar mechanisms might explain the beneficial effects of antibiotics or certain probiotics in the treatment of IBS.
La distinción entre operativo y financiero como base para el análisis contable: la aportación de Penman

Se desarrolla una revision critica de la aportacion de Penman al analisis contable. Despues de senalar lo que el autor entiende por actividad “economica” y actividad “financiera”, y el procedimiento de reclasificacion de los estados financieros acorde con esta dicotomia, se explica su aplicacion al analisis contable mediante una piramide reformulada de ratios. Tras sugerir algunas mejoras en el planteamiento teorico del modelo inicial de funcionamiento de la empresa, se destaca la utilidad y las ventajas de este modelo para el analisis de empresas y se indican algunas limitaciones.
Chronic non‐A, non‐B hepatitis: Ultrastructural and serologic studies

Liver biopsies from five patients with chronic non‐A, non‐B (NANB) hepatitis were examined by electron microscopy for hepatocellular alterations. Circular fused membranes were observed within the cytoplasm of hepatocytes of four of the patients. Aggregates of intranuclear particles, measuring 22 ± 2 nm in diameter, were also seen in two of the biopsies in which fused membranes were identified. Sera of all five patients formed precipitin lines detectable by counterimmunoelectrophoresis when reacted with serum from an individual convalescent from posttransfusion NANB hepatitis. Using this convalescent serum as an antibody source, complexes of 22 ± 2 nm particles were identified in three of the chronic patient sera by immunoelectron microscopy. These observations suggest that at least one of the agents responsible for NANB hepatitis elicits both nuclear and cytoplasmic modifications. Furthermore, the 22 ± 2 nm particles circulating in the sera of the chronic NANB patients may represent components related to NANB hepatitis agent.
Cochlear Implant Outcome Is Not Influenced by the Choice of Ear

Objectives: This study tested the hypothesis that patients with residual hearing in the nonimplanted ear had the same cochlear implant benefit whether the implanted ear had profound or severe hearing loss. Design: A retrospective chart review of adult cochlear implant recipients with postlingual hearing loss. Patients were categorized according to the pure-tone average of the implanted and contralateral ears as (a) bilateral profound, (b) severe-profound, and (c) bilateral severe. The results of a test battery of spoken language measures were compared among patients belonging to these hearing categories at 6, 12, and 24 months after surgery, using a t-test and multivariate regression analyses. Results: The presence of residual hearing in one or both ears was associated with significantly higher postoperative speech perception scores compared with participants with bilateral profound hearing loss. Among participants with similar amounts of residual hearing in the nonimplanted ear, however, there was no difference in speech recognition scores between those with profound and those with severe hearing loss in the implanted ear. Conclusions: Among participants with asymmetric hearing loss, there is no additional benefit to implanting the better-hearing ear that can be preserved for use with a hearing aid for better speech understanding in noise and sound localization. These results suggest that the additional benefit received by patients with residual hearing is mediated by trophic effects on crossed pathways in the central nervous system and is independent of the preoperative functional status of the implanted ear.
Role of the Innate Immune System in the Pathogenesis of Inflammatory Bowel Disease

Crohn disease and ulcerative colitis are chronic inflammatory diseases of the intestinal tract commonly denoted as inflammatory bowel diseases. It has been proposed that these diseases result from aberrant mucosal immune responses to nonpathogenic microbial residents of the intestines. Recently, it was established that continuous interactions between the innate and the adaptive intestinal immune cells and the microbiota are directly involved in maintaining the physiological noninflammatory state of the intestinal mucosa. In light of the complexity of this mucosal homeostasis, it is astonishing that the inflammatory bowel diseases are relatively rare. Recently, altered functions of the innate immune system have been identified. As such, both hyperresponsiveness and hyporesponsiveness of innate cells have been implicated in the pathogenesis of inflammatory bowel diseases.
Spectrum Analysis of Sidebands in Industrial Drives

This paper deals with the diagnosis of induction motors IM with the so-called motor current signature analysis MCSA. The MCSA is one of the most efficient techniques for the detection and the localization of electrical and mechanical failures, in which faults become apparent by harmonic components around the supply frequency. This paper presents a summary of the most frequent faults and its consequences on the stator current spectrum of an IM. A three-phase IM model was used for simulation taking into account in one hand the normal healthy operation and in the other hand the broken rotor bars, the shorted turns in the stator windings, the voltage unbalance between phases of supply and the abnormal behavior of load. The MCSA is used by many authors in literature for faults detection of IM. The major contribution of this work is to prove the efficiency of this diagnosis methodology to detect different faults simultaneously, in normal and abnormal functional conditions. The results illustrate good agreement between both simulated and experimental results.
Flipper stroke rate and venous oxygen levels in free-ranging California sea lions

ABSTRACT The depletion rate of the blood oxygen store, development of hypoxemia and dive capacity are dependent on the distribution and rate of blood oxygen delivery to tissues while diving. Although blood oxygen extraction by working muscle would increase the blood oxygen depletion rate in a swimming animal, there is little information on the relationship between muscle workload and blood oxygen depletion during dives. Therefore, we examined flipper stroke rate, a proxy of muscle workload, and posterior vena cava oxygen profiles in four adult female California sea lions (Zalophus californianus) during foraging trips at sea. Flipper stroke rate analysis revealed that sea lions minimized muscle metabolism with a stroke–glide strategy when diving, and exhibited prolonged glides during the descent of deeper dives (>100 m). During the descent phase of these deep dives, 55±21% of descent was spent gliding, with the longest glides lasting over 160 s and covering a vertical distance of 340 m. Animals also consistently glided to the surface from 15 to 25 m depth during these deeper dives. Venous hemoglobin saturation (SO2) profiles were highly variable throughout dives, with values occasionally increasing during shallow dives. The relationship between SO2 and flipper stroke rate was weak during deeper dives, while this relationship was stronger during shallow dives. We conclude that (1) the depletion of oxygen in the posterior vena cava in deep-diving sea lions is not dependent on stroke effort, and (2) stroke–glide patterns during dives contribute to a reduction of muscle metabolic rate. Summary: Flipper stroke rate has little impact on posterior vena caval oxygen depletion patterns in diving California sea lions. Use of a stroke–glide strategy also contributes to minimization of work effort.