Miracle-dz/UniFAR-FTUs huggingface dataset:
Seleção de modelos de regressão aleatória para ajuste de pesos do nascimento ao momento da seleção (378 dias) de machos Nelore.

Foram utilizados pesos (17.942 registros ) de 2.582 machos da raca Nelore, nascidos de 1976 a 2001, filhos de 186 touros e 1.035 matrizes, provenientes dos rebanhos selecionados (NeS e NeT) e controle (NeC) do Projeto de Melhoramento Genetico das Racas Zebu de Sertaozinho. Os dados foram classificados, em uma escala continua, em intervalos de sete dias de idade, perfazendo 60 idades, com o minimo de tres e o maximo de sete registros por animal. A grande maioria dos animais (96%) apresenta sete registros. Foram testados 21 modelos de regressao aleatoria, compostos por diferentes combinacoes de ordens (k) dos efeitos aleatorios genetico aditivo direto (A), de ambiente permanente do animal (C) e de ambiente permanente materno (Q), alem do efeito residual, com estruturas de variâncias homogeneas (R1) e heterogeneas, com quatro (R4) ou oito (R8) classes. Os efeitos fixos foram: grupo de contemporâneos (ano de nascimento, rebanho), mes de nascimento e idade da mae, alem da idade do animal ajustado sob polinomio ortogonal de Legendre de ordem tres. Os criterios de informacao Bayesiano de Schwarz (BIC) e de Akaike (AIC) acusaram os modelos com kA, kC e kQ iguais a 6,5,3 e 6,6,4 com respectivas variâncias residuais dividas em quatro (R4) ou oito classes (R8) como os mais adequados ao ajuste dos dados de machos Nelore do nascimento ao momento da selecao.
Influence of Borneol on In Vitro Corneal Permeability and on In Vivo and In Vitro Corneal Toxicity

This study examined whether borneol could enhance corneal drug permeability. Model drugs containing either synthetic or natural borneol were co-administered to isolated intact or de-epithelialized rabbit corneas and the apparent permeability coefficients were measured. Draize tests in rabbits and levels of isolated intact rabbit corneal hydration were used to measure in vivo and in vitro toxicity, respectively. Synthetic borneol (0.1%) increased corneal penetration of the lipophilic agents, indomethacin and dexamethasone, by 1.23 and 2.40, respectively, and of the hydrophilic agents, ofloxacin, ribavirin and tobramycin, by 1.87, 2.80 and 3.89, respectively. For natural borneol, the corresponding fold increases were 1.67, 2.00, 2.15, 2.18 and 3.39, respectively. Removing the epithelium attenuated the penetration-enhancing effects of borneol. Borneol (0.1%) did not damage corneal tissue. The ability of borneol to enhance drug penetration through the outer corneal layer, particularly for highly-hydrophilic drugs, suggests that further clinical investigation may be warranted.
Production, Manufacturing and Logistics Competitive advantage through take-back of used products

Motivated by a recent antitrust ruling against Hill–Rom, one of the two dominant American suppliers of hospital beds, we develop a stylized model to investigate the consequences of used product take-back on firms, industry and customers. Our findings suggest that by taking back and reselling refurbished products, a manufacturer can increase both profit margins and sales––to the detriment of a non-interfering competitor. In our model, customers are always better off under product take-back, but it depends on the degree of competition, whether firms use the benefits of takeback primarily to increase their margins or to pass them on to the customers by lowering their prices. The first firm to offer take-back, in some cases, can deter its competitors from following this profitable strategy, especially if it has an existing advantage in terms of lower production cost or higher market share. Contrary to the claim of Hill–Roms competitor, we find a ‘‘legitimate business justification’’ for Hill–Roms reduction of new product prices. 2003 Elsevier B.V. All rights reserved.
Tissue Doppler and Strain Rate Imaging Detect Improvement of Myocardial Function in Iron Deficient Patients with Congestive Heart Failure after Iron Replacement Therapy

Background: Iron deficiency may contribute to diminished exercise tolerance in patients with congestive heart failure (CHF) even in absence of anemia. The aim of this study was to evaluate the effect of correction of iron deficiency on functional capacity and myocardial function in patients with CHF. Methods: We studied 40 patients with ejection fraction <40%, hemoglobin% >12 g/dL, serum ferritin <100 ug/L, and transferrin saturation <20%. Patients received 200 mg weekly doses of iron dextran complex until serum ferritin level was between 200 and 300 ug/L or transferrin saturation level was between 30% and 40%. Transthoracic echocardiogram, tissue Doppler imaging, peak systolic strain rate, and 6 minute walk test were performed before iron therapy and at 12‐week follow up. Peak early diastolic myocardial tissue velocity (E’), peak late diastolic myocardial tissue velocity (A’), and peak systolic myocardial tissue velocity (S’) were measured. Results: There was a significant improvement of New York Heart Association functional class (3.0 ± 0.4 vs. 2.1 ± 0.3, P < 0.05) and 6minutes walk distance (322 ± 104 vs. 377 ± 76, P < 0.01) from rest to follow up, respectively. Ejection fraction did not change significantly (32 ± 8% vs. 34 ± 9%, respectively). There was a significant improvement of S’‐wave (3.0 ± 0.8 cm/sec vs. 6.0 ± 1.2 cm/sec, P < 0.05), E/E’ ratio (22 ± 3 vs. 13 ± 3, P < 0.05), and peak systolic strain rate (−0.72 ± 0.11/s vs. −1.09 ± 0.37/s, P < 0.05) from baseline to follow‐up, respectively. Conclusion: Correction of iron deficiency improves functional class and walking distance in nonanemic iron deficient patients with systolic heart failure. Tissue Doppler and strain rate demonstrated a significant improvement of diastolic and systolic function after therapy despite lack of improvement of ejection fraction. (Echocardiography 2012;29:13‐18)
The psychometric properties of the Ages & Stages Questionnaires for ages 2‐2.5: a systematic review

BACKGROUND Early identification of children with potential development delay is essential to ensure access to care. The Ages & Stages Questionnaires (ASQ) is used as population outcome indicators in England as part of the 2.5-year review. METHOD The aim of this article was to systematically review the worldwide evidence for the psychometric properties of the ASQ third edition (ASQ-3TM ) and the Ages & Stages Questionnaires®: Social-Emotional (ASQ:SE). Eight electronic databases and grey literature were searched for original research studies available in English language, which reported reliability, validity or responsiveness of the ASQ-3TM or ASQ:SE for children aged between 2 and 2.5 years. Twenty studies were included. Eligible studies used either the ASQ-3TM or the ASQ:SE and reported at least one measurement property of the ASQ-3TM and/or ASQ:SE. Data were extracted from all papers identified for final inclusion, drawing on Cochrane guidelines. RESULTS Using 'positive', 'intermediate' and 'negative' criteria for evaluating psychometric properties, results showed 'positive' reliability values in 11/18 instances reported, 'positive' sensitivity values in 13/18 instances reported and 'positive' specificity values in 19/19 instances reported. CONCLUSIONS Variations in age or language versions used, quality of psychometric properties and quality of papers resulted in heterogeneous evidence. It is important to consider differences in cultural and contextual factors when measuring child development using these indicators. Further research is very likely to have an important impact on the interpretation of the ASQ-3TM and ASQ:SE psychometric evidence.
The Agent Brain: A Review of Non-invasive Brain Stimulation Studies on Sensing Agency

According to philosophy of mind and neuroscientific models, the sense of agency can be defined as the sense that I am the one that is generating an action and causing its effects. Such ability to sense ourselves as causal agents is critical for the definition of intentional behavior and is a primary root for human interaction skills. The present mini-review aims at discussing evidences from non-invasive brain stimulation (NIBS) studies targeting functional correlates of different aspects of agency and evidences on the way stimulation techniques affect such core feature of human subjective experience. Clinical and brain imaging studies helped in defining a neural network mediating agency-related processes, which includes the dorsolateral prefrontal cortex (dlPFC), the cingulate cortex (CC), the supplementary and pre-supplementary motor areas (SMA and pre-SMA), the posterior parietal cortex (PPC) and its inferior regions and the cerebellum. However, while the plurality of those structures mirrors the complexity of the phenomenon, their actual roles with respect to different components of the experience of agency have been primarily explored via correlational techniques, without a clear evidence about their causal significance with respect to the integration of sensorimotor information, intentionalization, and action monitoring processes. Therefore, insights into the specific causal role of different cortical structures can be specified by using NIBS techniques, in order to provide improved understanding into the bases of our ability vs. inability to properly act in complex social contexts.
미세먼지 대응 행동 촉진을 위한 메시지 구성 전략 탐색 :심리적 거리감의 조절효과 및 불안 감정의 매개효과를 중심으로

이 연구의 목적은 미세먼지 위험 메시지가 개인의 대응 행동에 미치는 영향력을 검증하는 데 있다. 구체적으로, 미세먼지 발생에 대한 원인 귀인과 미세먼지 위험에 따른 결과의 불확실성 수준이라는 메시지 요인이 저감 행동 의도와 예방 행동 의도에 어떤 영향을 미치는지 살펴보았다. 또한, 이 과정에서 미세먼지 위험에 대한 심리적 거리감의 조절 효과와 불안 감정의 매개 효과가 유효한지 확인하였다. 연구 결과, 원인 귀인과 불확실성 수준이 행동 의도에 미치는 영향은 유의미하지 않았다. 한편, 메시지 효과에 대한 심리적 거리감의 조절 효과는 유의미한 것으로 나타났다. 구체적으로, 미세먼지 위험에 대한 심리적 거리가 가까운 경우에는 메시지 요인에 따른 예방 행동 의도의 차이가 통계적으로 유의하지 않았으나, 미세먼지 위험에 대한 심리적 거리가 먼 경우에는 외부 귀인 메시지를 받은 참가자보다 내부 귀인 메시지를 받은 참가자가 미세먼지 위험의 불확실성 수준에 민감하게 반응하였다. 마지막으로, 불안이라는 감정의 매개 효과는 저감 행동 의도 및 예방 행동 의도에서 모두 유의하게 나타나, 행동 동기를 자극하는 데 있어 감정의 역할이 중요함을 확인할 수 있었다. 본 연구의 결과는 미세먼지 위험 커뮤니케이션 전략을 수립하는 데 이론적·실무적으로 기여할 것으로 기대된다.
Minimizing acquisition time of arterial spin labeling at 3T

An improved arterial spin labeling (ASL) perfusion technique that combines pseudo‐continuous labeling and a T2*‐insensitive sequence (GRASE) with background suppression was used to acquire perfusion maps in normal volunteers and stroke patients. It is shown that perfusion measurements obtained in less than 1 min of scan time are reproducible, with a coefficient of variation of 7%. The perfusion maps generated from these data can be used to characterize the stroke lesion. Magn Reson Med 59:1467–1471, 2008. © 2008 Wiley‐Liss, Inc.
Winter dysentery in cows associated with Bovine Coronavirus ( BCoV )

Winter dysentery is an epizootic acute infectious and contagious disease with a seasonal trend that affects adult bovines worldwide, with a higher prevalence in dairy cows, caused by Bovine Coronavirus (BCoV), with cases of association with Salmonella sp, rotavirus, Bovine Viral Diarrhea Virus, Crysptosporidium parvum and Eimeria bovis (Campbell and Cookingham, 1978). The disease was first reported in Brazil in 2002 in a dairy farm in São Paulo State (Brandão et al., 2002).
Pulmonary hypertension in interstitial lung disease

Pulmonary hypertension (PH) may complicate the course of many forms of advanced interstitial lung disease (ILD) and has been shown to portend a worse outcome. The aetiology of PH is likely multifactorial with variable contribution of factors amongst the different diseases. The most common such conditions include idiopathic pulmonary fibrosis, sarcoidosis, connective tissue disease‐related ILD and pulmonary langerhans cell histiocytosis. Whether the course and impact of PH in these conditions can be modified by therapy requires further study.
Transport of Drugs Across the Hepatic Sinusoidal Membrane: Sinusoidal Drug Influx and Efflux in the Liver

The liver plays an important role in the detoxification of xenobiotics. Recently, many secondary active transporters responsible for sinusoidal drug uptake have been cloned and their transport properties have been determined. These include rat and human Na(+)-taurocholate cotransporting polypeptides, rat and human organic anion transporting polypeptides, rat and human prostaglandin transporters, rat organic anion transporters, and rat and human organic cation transporters. In addition, it has been suggested that the expression of multi-drug resistance associated protein 3, a primary active transporter responsible for the cellular extrusion of organic anions, on the sinusoidal membrane is induced under cholestatic conditions. In this article, drug transport across the sinusoidal membrane is summarized, particularly focusing on the molecular mechanism of transport.
Méthode des prix hédoniques et évaluation des actifs environnementaux : application au cas du littoral

Cette these a pour objet de demontrer que la methode des prix hedoniques constitue un outil majeur d'evaluation des actifs environnementaux. L’application au littoral finisterien et a la zone estuarienne de Port-Jerome illustre les avantages et limites associes a cette methode. Si, dans le cas du Finistere, cette derniere permet de mettre en evidence l’importance que les menages residents attribuent au littoral, il n’en est pas de meme dans le cas de Port-Jerome : la presence d’installations industrielles risquees et polluantes a proximite de l’estuaire de la Seine ne permet pas d’isoler la valeur specifique attribuee par les menages a cet actif environnemental de celle associee aux risques industriels. Nous montrons egalement que cette methode peut constituer un outil d’aide a la decision en servant de base au calcul ex ante des indemnisations des menages expropries, dans le cadre fictif d’une politique publique restreignant l’usage residentiel du littoral. Pour ce faire, nous mettons en place une nouvelle procedure basee sur la variation de surplus de consommation des menages residents suite a la modification de plusieurs attributs environnementaux. Cette derniere a pour avantage de s’appliquer a des fonctions de demande marshallienne a la difference de la procedure de Freeman qui suppose la neutralite de l’ordre des changements des amenites. Enfin, cette these traite la question de la prise en compte d’effets de negociation dans la fonction de prix hedoniques et en particulier de l’effet de la vacance des logements dans le cadre d’un modele econometrique a retard spatial. Nos resultats, appliques a la zone de Port-Jerome, indiquent la presence d’un tel effet.
Sibling Comparisons and Confounding in Autism Epidemiological Studies--Reply.

CRP levels reflecting acute inflammation and the likelihood of confounding by medical conditions. In this sample, we found that (1) the somatic and nonsomatic symptom clusters were positively associated with CRP in separate models and (2) only the somatic cluster (sleep disturbance, fatigue, appetite changes, and psychomotor retardation/agitation) remained associated in the model with both symptom clusters. However, our results came with a critical caveat—one size did not fit all. Our examination of race/ethnicity as a moderator revealed some striking results, as the depression-inflammation link was missing in all but 1 group: non-Hispanic white individuals (n = 4858). To our surprise, there were no significant associations between somatic and nonsomatic symptoms and CRP in non-Hispanic black (n = 1978), Mexican American (n = 2260), or other Hispanic (n = 1053) individuals. Inadequate power is not a plausible explanation, given the group sizes. Altogether, our findings suggest that the depressioninflammation association is largely due to the somatic symptoms and may be present only in non-Hispanic white individuals. There is now a clear need to test race/ethnicity as a moderator in depression-inflammation studies. To our knowledge, few such studies exist, and results have been conflicting.5 Determining the role of race/ethnicity is of high potential significance. It could inform the development of novel depression treatments and cardiometabolic disease prevention approaches tailored for specific racial/ethnic groups, which could significantly reduce racial/ethnic disparities in depression, cardiovascular disease, diabetes mellitus, and obesity. In the era of personalized health care, the questions “In whom? ” and “For whom? ” must remain in the forefront of our minds.
Fabrication of nanostructures by plasma and laser assisted synthesis in liquids

In this paper capabilities of electrical discharge plasma and laser irradiation processes in liquids for synthesis of nanoparticles (NPs) of different morphology and composition are discussed. The main attention has been focused on the properties of carbon, silicon, as well as alloyed and composite NPs. Particles with size in the nanometric range (3–50 nm) with different crystal structures were produced depending on the preparation procedure. In addition, the targeted changes of the NPs properties (their size and composition) were shown to be sensitively controlled via additional plasma and laser treatment of the prepared suspensions. It is supposed that under additional laser irradiation the compound nanoparticles are formed in result of nanoparticles heating, co-melting and chemical reactions in the liquid droplet.
How hospitals practice cost containment with selective contracting and the Medicare Prospective Payment System.

plementation of the Medicare Prospective Payment System (PPS) and the shift by private insurers from open-panel, fee-for-service plans to HMO and PPO selective contracting plans has restrained the growth of hospital costs.1-5 Many of these studies examine total aggregate hospital costs and so provide little information on how hospitals controlled costs. The cost containment observed in these studies could have been the result of reductions in the number of serv-
Biomedical Ultrasound Image Enhancement using SRAD

In this paper we present Speckle Reducing Anisotropic Diffusion (SRAD) technique that uses wavelet decomposition. This technique is able to preserve and enhance edges while smoothing homogeneous regions in ultrasound images. SRAD is applied on various real biomedical ultrasound images with different number of iterations. The performance of SRAD filter is found to be much better than conventional Lee, Frost filters. SRAD gives less MSE, higher PSNR and better FOM. The experiemental results show that this technique works effectively both in terms of speckle reduction, edge preservation and edge enhancement. General Terms Techniques, Experiements.
Qualité de Service et calcul de chemins dans les réseaux inter-domaine et multicouches. (Quality of Service and path computation in inter-domain and multi-layer networks)

La Qualite de Service (Quality of Service - QoS) est une garantie de parametres reseau (bande passante elevee, delai court, etc.). Dans un reseaux inter-domaine, elle peut etre assuree par des contrats entre domaines appeles Service Level Agreements (SLA). Dans cette these, nous nous interessons d’abord a l’etape de negociation de SLA : la selection des SLA proposes par un domaine. Nous proposons des methodes exactes et approchees permettant aux domaines de proposer les SLA qui maximisent leurs revenus. Nous etudions egalement l'impact de la reputation des domaines sur cette negociation. Au niveau de l’instanciation des SLA, nous nous interessons au calcul de chemins qui prennent en compte les encapsulations de protocoles (afin de pallier l’heterogeneite technologique des domaines). En utilisant des outils de theorie des langages, nous proposons la premiere solution polynomiale au calcul de chemins dans un tel contexte
Novel RF interference rejection technique using a four-port diplexer

A novel RF interference rejection technique using four-port network is presented in this paper by using two diplexers combined together. This technique offers the signal isolation of 68.46 dB between transmitter and receiver module, which is the best figure ever reported. The four-port network exploits both high and low-Q factor filters for the cost reduction. The design tolerance with phase deviation between 180o and 183o of four-port network was investigated and the novel concept still has signal isolation (S32) of better than 65.47 dB, which is still superior compared to the existing diplexer. Finally, RF interference rejection technique can be used in wireless communication systems whereas small size, low losses and low complexity are required.
Aspirin-exacerbated respiratory disease: characteristics and management strategies

Aspirin-exacerbated respiratory disease is a clinical entity comprising chronic rhinosinusitis with nasal polyposis, asthma and intolerance to COX-1 inhibiting drugs. The pathogenesis is not completely understood at this point, but abnormal arachidonic acid metabolism is a key feature in this syndrome. The diagnosis is confirmed only by direct drug challenge. Aspirin desensitization followed by daily aspirin therapy is a useful treatment option in these patients. In this review article are discussed the important characteristics and treatment of aspirin-exacerbated respiratory disease.
Cartographie génétique de gènes candidats pour la qualité du bois chez l'Eucalyptus

Dans le cadre du programme d'amelioration genetique des eucalyptus au Congo, des recherches en biotechnologie ont ete engagees pour detecter des locus impliques dans la variation de caracteres quantitatifs (QTL : Quantitative Trait Loci) pour la qualite du bois. Les travaux de genomique fonctionnelle menes par le CIRAD en collaboration avec des organismes publics (CNRS) et prive (RAIZ et ENCE), ont permis de developper une banque d'EST (Expressed sequence tag) surexprimees dans le xyleme. Ces EST pourraient constituer de bons candidats pour une selection assistee par marqueurs de la qualite du bois. Afin d'ajouter un attribut " positionnel " a ces genes candidats " expressionnels ", les chercheurs du CIRAD souhaitent etudier les colocalisations entre les QTL de qualite du bois et ces genes sur les cartes genetiques d'eucalyptus. Dans ce contexte, l'objectif de ce stage etait de tester differentes methodes de revelation du polymorphisme nucleotidique afin de pouvoir cartographier ces genes. Trois methodes ont donc ete utilisees pour la cartographie genetique des EST : la PCR en temps reel, la SSCP sur sequenceur LI-COR et la SSCP sur sequenceur ABI. La mise en evidence du polymorphisme n'a pas ete possible par la methode de PCR en temps reel. A l'inverse, les techniques SSCP sur LI-COR et ABI se sont revelees tres efficaces pour le genotypage haut debit. Ainsi, pour les 61 EST d'E. gunnii etudiees, 7 EST polymorphes ont ete cartographiees sur les cartes genetiques d'Eucalyptus, grandis et E. urophylla deja existantes. L'ajout de ces EST a permis d'identifier un cluster de genes colocalisant avec des QTL de densite du bois sur le groupe de liaison 4 et d'augmenter les zones homologues entre cartes au sein du groupe de liaison 10. L'ajout de marqueurs codominants de type microsatellites sur les cartes d'E. grandis et E. urophylla devrait permettre d'etudier la synthenie et la colinearite a travers differentes especes du genre Eucalyptus, ceci etant un prerequis pour la comprehension de l'evolution du genome de l'eucalyptus et pour le transfert d'information genetique d'une espece a une autre. (Resume d'auteur)