Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of SAF‐A, a novel nuclear DNA binding protein from HeLa cells with high affinity for nuclear matrix/scaffold attachment DNA elements.

We identified four proteins in nuclear extracts from HeLa cells which specifically bind to a scaffold attachment region (SAR) element from the human genome. Of these four proteins, SAF‐A (scaffold attachment factor A), shows the highest affinity for several homologous and heterologous SAR elements from vertebrate cells. SAF‐A is an abundant nuclear protein and a constituent of the nuclear matrix and scaffold. The homogeneously purified protein is a novel double stranded DNA binding protein with an apparent molecular weight of 120 kDa. SAF‐A binds at multiple sites to the human SAR element; competition studies with synthetic polynucleotides indicate that these sites most probably reside in the multitude of A/T‐stretches which are distributed throughout this element. In addition we show by electron microscopy that the protein forms large aggregates and mediates the formation of looped DNA structures.
Hydrophilic and hydrophobic poly(l‐lactic acid) films by building porous topological surfaces

Surface wettability of thin films is significant for their functional properties. Poly(l-lactic acid) (PLLA) is proposed as film matrix for building porous topological surfaces. By controlling the dope composition and ambient conditions, the films with ordered pores at micrometer scale are obtained. The results demonstrate that the hydrophilic or hydrophobic surface can be realized by building the porous topological surfaces. Increasing polymer concentration can lead to decreased pore size. The transition behavior of surface pores from discrete bowl-like to interconnected honeycomb-like structure with the increasing humidity is observed. The contact angle of top surface of film is higher than that of bottom surface, which verified the different roughness performance. The morphology and scale of topological structure are markedly related with the template effect of water droplets. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44572.
DECREASED VASODILATION INDUCED BY A NEW NITRIC OXIDE DONOR IN TWO KIDNEY, ONE CLIP HYPERTENSIVE RATS IS DUE TO IMPAIRED K+ CHANNEL ACTIVATION

1. We studied the effect of the new compound trans‐[RuCl([15]aneN4)NO]2+ (15‐ane) in denuded aortic rings of two kidney (2K) normotensive and two kidney, one clip (2K‐1C) hypertensive rats.
The robot-assisted sensor deployment problem in Wireless Sensor Networks

Using the mobile robot to carry static sensors and deploy sensors at proper positions is an efficient method to solve the sensor deployment problem in wireless sensor networks (WSNs). In this paper, we assume a more practical environment compared to most studies of this problem. The goal of the proposed algorithm is to plan a shorter traveling path for the robot to relocate the redundant sensors in the target field. The performance evaluation done in this paper has verified the effectiveness of the proposed algorithm.
It is Unlikely That Influenza Viruses Will Cause a Pandemic Again Like What Happened in 1918 and 1919

Influenza and influenza viruses are wellknown popular topics to medical professionals and the general public. Influenza viruses had caused a pandemic globally during 1918 and 1919, and that influenza pandemic had taken away more than 20 million people’s lives in the world. However, in my opinion, it is unlikely that influenza viruses will again cause a pandemic on a level (both of the morbidity rate and the mortality rate) comparable to what happened in 1918 and 1919. Influenza viruses very easily reassort, recombine, and point mutate in nature due to their segmented RNA genome structures, however, unlike highly pathogenic (virulent) viruses like rabies virus, Lassa fever virus, smallpox virus, eastern equine encephalitis virus, Ebola virus, Marburg virus, and human immunodeficiency virus 1 (HIV-1); most influenza viruses (wild types and mutants) are moderately pathogenic. The case fatality rates of some highly virulent viruses and related references are listed in Table 1.
Effect of race and socioeconomic status in the treatment of appendicitis in patients with equal health care access.

BACKGROUND Lower socioeconomic and minority racial/ethnic status have been linked to delays in surgical care and thus higher appendiceal perforation rates. HYPOTHESIS Equal access to health care eliminates the previously reported socioeconomic and racial/ethnic disparities in rates of appendiceal perforation. DESIGN Retrospective cohort study using discharge abstract data and US census data. SETTING Twelve regional Kaiser Permanente hospitals in southern California. PATIENTS A total of 16,156 patients treated for appendicitis. Patients were divided into low, medium, and high groups based on annual household income and educational level, as well as racial/ethnic status (white, black, Hispanic, and Asian). MAIN OUTCOME MEASURES Appendiceal perforation (AP) rate and length of hospitalization (LOH). RESULTS The adjusted odds ratio for AP was lower in Hispanics and similar in blacks and Asians compared with whites. The odds ratio for AP was similar in high- and medium-income families compared with low-income families. The odds ratio for AP was higher in patients with high educational levels and similar in those with medium educational levels compared with low educational levels. The adjusted LOH was longer in blacks, shorter in Hispanics, and similar in Asians compared with whites. The LOH was similar in high- and medium-income families compared with low-income families. The LOH was higher in patients with medium educational levels and similar in those with high educational levels compared with low educational levels. CONCLUSIONS Lower socioeconomic background and minority race/ethnicity did not correlate with higher AP rates or a clinically longer LOH in patients with equal access to care. Based on these findings, we believe that equal health care access leads to equivalent outcomes in all patients with appendicitis.
Definability of the ring of integers in some infinite algebraic extensions of the rationals

Let K be an infinite Galois extension of the rationals such that every finite subextension has odd degree over the rationals and its prime ideals dividing 2 are unramified. We show that its ring of integers is first‐order definable in K. As an application we prove that \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}${\mathbb Q}(\lbrace \cos (2\pi /\ell ^n) : \ell \in \Delta , n \in {\mathbb N}\rbrace )$\end{document} together with all its Galois subextensions are undecidable, where Δ is the set of all the prime integers which are congruent to −1 modulo 4.
Análisis de la situación en España de la implantación de la Mejora Continua a través de sistemas de participación del personal

El objetivo de este trabajo es presentar un analisis de la situacion de las empresas en Espana sobre el modo con el que abordan el proceso de mejora continua a traves de sistemas de participacion del personal (en adelante SPP). Para ello, se ha realizado un estudio de campo en el ambito espanol con el fin de: conocer el grado y modo de implantacion del proceso de mejora continua a traves de los SPP, valorar posibles problematicas y ofrecer una perspectiva de futuro.
Colour-based relevance feedback for image retrieval

Colour is an important attribute for image matching and retrieval, and relevance feedback (RF) has been found to improve the retrieval effectiveness in information retrieval systems significantly. We propose a new approach for colour-based RF for image retrieval. The approach makes use of the Multi-Interval Discretization Algorithm to discretize the range of colour histogram values into discrete colour intervals. The probabilistic 0.5 formula is adapted to identify significant colour intervals which are then used to refine the initial query. In addition, knowledge is extracted from the relevance judgement information and represented as a colour interval decision tree. The decision tree is used to aid in classifying the images, retrieved using the modified query in subsequent retrieval, into the relevant and non-relevant sets. Extensive tests on a large image collection were conducted to demonstrate the effectiveness of our proposed RF approach.
Evaluation of Ionotropic Cross-Linked Chitosan/Gelatin B Microspheres of Tramadol Hydrochloride

Microspheres of tramadol hydrochloride (TM) for oral delivery were prepared by complex coacervation method without the use of chemical cross-linking agents such as glutaraldehyde to avoid the toxic reactions and other undesirable effects of the chemical cross-linking agents. Alternatively, ionotropic gelation was employed by using sodium-tripolyphosphate as cross-linking agent. Chitosan and gelatin B were used as polymer and copolymer, respectively. All the prepared microspheres were subjected to various physicochemical studies, such as drug–polymer compatibility by thin layer chromatography (TLC) and Fourier transform infrared (FTIR) spectroscopy, surface morphology by scanning electron microscopy, frequency distribution, drug entrapment efficiency, in vitro drug release characteristics and release kinetics. The physical state of drug in the microspheres was determined by differential scanning calorimetry (DSC) and X-ray diffractometry (XRD). TLC and FTIR studies indicated no drug–polymer incompatibility. All the microspheres showed initial burst release followed by a fickian diffusion mechanism. DSC and XRD analysis indicated that the TM trapped in the microspheres existed in an amorphous or disordered-crystalline status in the polymer matrix. From the preliminary trials, it was observed that it may be possible to formulate TM microspheres by using biodegradable natural polymers such as chitosan and gelatin B to overcome the drawbacks of TM and to increase the patient compliance.
Enhanced Photodetection by Glancing Angle Deposited Vertically Aligned TiO2 Nanowires

The TiO2 thin film (TF) and nanowires (NWs) have been synthesized on Si substrate from pellets of pressed and sintered TiO2 powder using e-beam evaporation. The glancing angle deposition technique is adopted for the growth of TiO2 NWs. Field emission gun-scanning electron microscope analysis manifests the growth of vertically aligned NWs of length ~362 nm and diameters ranging from ~50 to ~290 nm. Energy dispersive X-ray analysis of NW sample shows the presence of Titanium (Ti), Oxygen (O2) and Silicon (Si). The transmission electron microscope analysis also confirms successful growth of NWs and the selected area diffraction pattern shows the bright spot patterns from the crystals. X-ray diffraction of TF and NWs deposited at ambient temperature demonstrate multiple peaks from the anatase phase of TiO2 which supports the selective area diffraction pattern result. Under light exposure, the current densities for TF and NW device are ~5.11 and ~10.03 μA/cm2, respectively, at +6.5 V. A maximum photosensitivity of ~10 times is recorded for the NW device at -6.5 V. An excellent response with rise and fall times of ~0.16 and ~0.17 s respectively is observed during switching on and off of white light at +8 V for the NW device, which confirms promising photodetection applications.
IDnet Mesh : Building a Trust Zone on the Internet

The current Internet architecture hides a user’s real identity by desig n, which is an important factor contributing to the Internet’s great success. However, as the Internet is qu ickly moving towards the mainstream of the societies nowadays, it is also raising tremendous problems on a daily basis, simply because there are no effective means to enable user accountability. In this paper, we study the feasibility to build a trust zone on the Internet, which will be capable to protect children from sexual pred ators and cyber bullies, to allow people to engage in online jobs without fear of scamming, to relieve Web 2.0 site s from spams and vandals, and to foster true collaboration among individuals who never meet each othe r in p rson, etc. To this end, we propose IDnet Mesh, a distributed user authentication infrastructure that serves as the gateway to the trust zone. It offers to validate two types of user accountab ility s the basis of trust. The first type of accountability allows an anonymous user to be deanonymized to his or her real identity when a dispute (e.g., a crime) happens; it can help to enforce laws and commonly accepted policies. The second type of accountability can effectively counter Sybil attacks; it can help to enfo rce even subjective policies specific to each application provider. Meanwhile, to be qualified as a basic I nternet-wide infrastructure, the IDnet Mesh is also designed to provide a very high service scalability an d reliability, including: (i) to be scalable to authenticate potentially billions of Internet users, ( ii) to withstand therefore high volumes of service requests, and ( iii) to be resilient to distributed denial-of-service attacks. The deployment of the IDnet Mesh can be fully incremental — no changes to the existing Internet in frastructure and protocols are required and all modifications stay at the application layer.
Milan criteria in liver transplantation for hepatocellular carcinoma: An evidence‐based analysis of 15 years of experience

Hepatocellular carcinoma (HCC) is the seventh most common cancer worldwide and the third most common cause of cancer-related deaths; the number of new cases per year is approaching 750,000. The magnitude of the incidence of HCC has discouraged any attempts to apply liver transplantation (LT) as the prevailing curative therapy for HCC worldwide because of the limited sources of donated organs (deceased and living donors) and the poor access to sophisticated health care systems in some geographical areas. If these limitations continue to prevail throughout the world, any attempt to significantly reduce HCC-related mortality rates through the application of LT will be delusional. International experiences have confirmed, however, the potential of LT to definitively cure HCC because it presents a unique opportunity to remove both the tumor (HCC is associated with 695,000 deaths per year) and the underlying cirrhosis. Despite its limited access, LT has become the standard of care for patients with small HCCs and the main driving force for alternative strategies offered to patients with intermediate HCCs. In 1996, a prospective cohort study defined restrictive selection criteria that led to superior survival for transplant patients in comparison with any other previous experience with transplantation or other options for HCC. Since then, these selection criteria have become universally known as the Milan criteria (MC) in recognition of their origin. Ever since their adoption in clinical practice, the MC have helped doctors to single out early-stage HCC as a prognostic category of cancer presentation that is amenable to curative treatments. After their implementation, the favorable posttransplant outcomes that were observed in cohort series were so convincing that the MC immediately became the standard of care for early HCC, and further validation by randomized controlled trials (RCTs) was prevented. After the passage of approximately a decade, researchers began to challenge the MC with other proposals designed to capture those patients not meeting the MC who could achieve similar posttransplant survival rates through the expansion of the accepted tumor limits for transplant eligibility. None of these expanded criteria have become the new reference standard for selecting LT candidates with HCC; any broadening of the selection criteria for transplantation is inevitably hampered by severe
Towards an unsupervised optimal fuzzy clustering algorithm for image database organization

In this paper, an unsupervised optimal fuzzy clustering (UOFC) algorithm is proposed for the classification of images. The main advantage of UOFC is that it can deal with clusters of arbitrary shape, as well as the ability to improve the convergence rate and optimality of the algorithm. In addition, the cluster validity criterion, which combines the properties of the fuzzy membership degrees and cluster geometrical properties, is used in the UOFC algorithm to evaluate the goodness of clustering. The UOFC algorithm is evaluated by simulation data as well as Brodatz textures, represented by the Gabor features.
A Phase-Field Model Coupled with Lattice Kinetics Solver for Modeling Crystal Growth in Furnaces

In this study, we present a new numerical model for crystal growth in a vertical solidification system. This model takes into account the buoyancy induced convective flow and its effect on the crystal growth process. The evolution of the crys- tal growth interface is simulated using the phase-field method. A semi-implicit lattice kinetics solver based on the Boltzmann equation is employed to model the unsteady incompressible flow. This model is used to investigate the effect of furnace operational conditions on crystal growth interface profiles and growth velocities. For a simple case of macroscopic radial growth, the phase-field model is validated against an ana- lytical solution. The numerical simulations reveal that for a certain set of temperature boundary conditions, the heat transport in the melt near thephase interface is diffusion dominant and advection is suppressed.
Dietary and Pharmacological Control of Calcium and Phosphate Metabolism in Dialysis Patients

Chronic kidney disease-mineral and bone disorder is a new term defining a complex syndrome which underlines the need of a systemic approach to disturbances of calcium and phosphate metabolism in patients with renal failure. In recent years, the availability of new phosphorus binders and the appearance of new selective vitamin D receptor activators and calcimimetics have increased our current armamentarium and have changed previous paradigms. All these drugs can be used in combination, acting in distinct yet complementary pathways, with a resultant improvement in their individual clinical profile and reduction in secondary effects, while enhancing the achievement of clinical guideline targets. On the other hand, we should be aware that treatment costs are increasing and most of our knowledge is opinion-based. In this article, we shall consider rational recommendations on the control of calcium, phosphorus and parathyroid hormone while awaiting new evidence. We shall also briefly review some important related issues such as vascular calcification, adynamic bone disease, osteoporosis and the need of parathyroidectomy. Future guidelines may modify current recommendations, but we believe that the lack of an absolute evidence is not equivalent to the lack of awareness of the important problem which chronic kidney disease-mineral and bone disorder represents.
Simultaneous high performance liquid chromatography analysis of water soluble vitamins in some foods prepared by a Nigerian eatery

The present study carried out simultaneous analysis of water soluble vitamins (thiamine, pyridoxine, niacin, folic acid and ascorbic acid) in some foods prepared by a Nigerian eatery using a reverse phase high performance liquid chromatography. The results (mg /100 g) indicate that pyridoxine ranged from 0.16 in amala to 1.14 in fried rice, niacin from 0.18 in doughnut to 0.70 in meat pie, thiamine from 0.30 in doughnut to 2.40 in cowpea. Ascorbic acid was lowest in doughnut and highest in eba composite meal while folic acid ranged from 30 μg /100 g in doughnut to 195 μg /100 g in meat pie. Thiamine was significantly higher in village kitchen meals and below detection limit in meal of rice alone. The gram per serving of the village kitchen would give 108-200% and 32-48 % of the recommended dietary allowance (RDA) for thiamine and folic acid, respectively, whereas the level of ascorbic acid was too low to meet the RDA. The study shows that fast foods have low content of water soluble vitamins and its consumption could compromise intake of some vitamins. Key words: Thiamine, pyridoxine, niacin, folic acid, ascorbic acid, eatery.
DNA Damage and Cellular Stress Responses Suppression of Autophagy by FIP 200 Deletion Impairs DNA Damage Repair and Increases Cell Death upon Treatments with Anticancer Agents

Autophagy is a lysosomal bulk degradation process for intracellular protein and organelles. FIP200 (200 kDa FAK-family interacting protein) is an essential component of mammalian autophagy that is implicated in breast cancer in recent studies. Here we show that inactivation of FIP200 resulted in deficient repair of DNA damage induced by ionizing radiation and anticancer agents in mouse embryonic fibroblasts (MEF). The persistent DNA damage correlated to increased apoptosis and reduced survival of FIP200 knockout (KO) MEFs after treatments with camptothecin (CPT), a topoisomerase I inhibitor and chemotherapeutic agent. Reexpression of FIP200 in FIP200 KOMEFs restored both efficient DNA damage repair and cell survival. Furthermore, knockdown of the increased p62 expression in FIP200 KO MEFs rescued the impaired DNA damage repair and CPT-induced cell death. In contrast, treatment of cells with N-acetyl cysteine did not affect these defects in FIP200 KO MEFs. Finally, FIP200 KO MEFs also showed deficient DNA damage repair and increased cell death compared with control MEFs, when treated with etoposide, a topoisomerase II inhibitor and another anticancer agent. Together, these results identify a new function for FIP200 in the regulation of DNA damage response and cell survival through its activity in autophagy and suggest the possibility of FIP200 or other autophagy proteins as a potential target for treatment to enhance the efficiency of cancer therapy using DNA damage–inducing agents.Mol Cancer Res; 9(9); 1–10. 2011 AACR.
VMDetector: A VMM-based Platform to Detect Hidden Process by Multi-view Comparison

Recently, "rootkit" becomes a popular hacker malware on the Internet, which controls the hosts on the Internet by hiding itself, and raises a serious security threat. Existing host-based and hardware-based solutions have some disadvantages, such as hardware overhead and being discovered by root kits, where the development of virtualization technology provides a better solution to avoid those. Virtual machine monitor has the highest authority on the virtual machine, and has the right to control the activities in the virtual machine without being found by root kits in the virtual machines. We propose VM Detector based on this hardware virtualization technology, using multi-view detection mechanism, to detect hidden processes inside the virtual machine on many aspects, then to improve the virtual machine's security. Through several experiments, VM Detector carried on the process detection effectively, and introduced less than 10% performance overhead.
New approach clustering algorithm for customer segmentation in automobile retailer industry

This research presents a new method for automatic customer segmentation based on usage behavior, without using a human specialist. In addition, the research focuses on profiling customers and finding a relation between the profile and the segments. The customer segments were constructed by applying modified Gustafson-Kessel clustering algorithm. The customer’s profile was based on personal information of the customers. A novel Support Vector Machines was used to estimate the segment of a customer based on his profile.To demonstrate the efficiency of the proposed method, this work performs an empirical study of a Nissan automobile retailer to segment over 5000 customers. This led to solutions for the customer segmentation with six segments.