Miracle-dz/UniFAR-FTUs huggingface dataset:
Topical Compounded Pain Creams and Pain Perception: Preliminary Findings The TOPCAPP Study

varying analgesic groups, including nonopioid analgesics (ie, acetaminophen and nonsteroidal anti-in! ammatory drugs (NSAIDs), adjuvant analgesics, and both weak and strong opioids. The process is known as multimodal analgesia and further supports the concept that pain is best managed by combination therapy. Therefore, combinations of more than one drug are often used with the goal of achieving better pain relief, fewer side effects, or both. Unfortunately, combination analgesia increases the risk of drug-drug interactions and systemic side effects. However, many pain medications are amenable to topical administration; they encompass a wide range of pharmaceutical classes (Table 1.0), each with different mechanisms of action targeting speci" c locations in pain pathways. Furthermore, topical pain preparations have advantages over traditional medications employed to treat pain. Topical delivery allows for local pain relief and negligible systemic absorption, thus resulting in reduced patient exposure to systemic side effects and avoidance of drugdrug interactions, which are often seen with oral and parenteral medications. With pain rarely being communicated by a single pathway, as previously discussed, topical preparations provide multiple mechanisms of treating pain and can be customized to patients based on their type of pain in one convenient, easy-to-use formulation. Thus, customized, multi-ingredient formulas containing various analgesic classes are conceptually attractive for addressing the burgeoning population of patients with acute and chronic pain who would otherwise be treated with single or combination systemic analgesics. Medimix Specialty Pharmacy specializes in compounding individualized topical therapies that address unmet medical needs. With respect to pain, Medimix compounds customized topical analgesics containing various combinations of evidence-based analgesics (Table 1.0) in a stateof-the-art Pharmacy Compounding Accreditation Topical Compounded Pain Creams and Pain Perception: Preliminary Findings
Impact d'éléments génétiques variables sur l'expression de quatre gènes de virulence chez streptococcus agalactiae

Nous avons etudie l’impact d’elements genetiques variables sur l’expression de quatre genes de virulence, lmb, scpB, fbsA et fbsB, permettant respectivement l’attachement a la laminine, a la fibronectine et au fibrinogene humain, chez Streptococcus agalactiae, premiere cause d’infections neonatales. L’etude de l’impact de la sequence d’insertion IS1548 et de l’intron de groupe II GBSi1, inseres dans la region intergenique scpB-lmb en amont du gene lmb, sur l’expression des genes lmb et scpB, montre que i) la structure de la region intergenique scpB-lmb correle avec les lignees phylogenetiques constituant l’espece; ii) la presence d’IS1548 ou de GBSi1 n'a aucune influence sur l'expression du gene scpB; iii) l’expression du gene lmb est significativement plus elevee chez les souches possedant IS1548; et iv) IS1548 active directement le gene lmb. L’etude des proprietes de liaison au fibrinogene des souches du clone invasif CC17 par rapport aux souches des autres lignees phylogenetiques montre que i) des combinaisons specifiques de genes fbs et de leur genes regulateurs correlent avec les lignees; ii) le systeme a deux composants RgfA/C inhibe le gene fbsA et active le gene fbsB; et iii) la proteine FbsB joue un role majeur dans la capacite de liaison au fibrinogene des souches de CC17.
Contributo per la gestione della resistenza in Cydia molesta: sensibilità di base a triflumuron

RIASSUNTO Cydia molesta è un fitofago chiave per la coltura del pesco in Italia. In molti disciplinari di produzione integrata attualmente la difesa contro questo fitofago, è basata sull’utilizzo di prodotti che agiscono in modo specifico sui meccanismi di sviluppo degli insetti. Maggiore è l’impiego di tali prodotti e maggiore è il rischio di comparsa di popolazioni resistenti. Per valutare la sensibilità di base ad uno dei prodotti maggiormente impiegati (triflumuron) sono stati allestiti dei biosaggi con uova neodeposte e larve mature di C. molesta. I risultati dei biosaggi serviranno come riferimento per valutare in futuro variazioni di sensibilità verso questo insetticida nelle popolazioni di campo del Lepidottero. Parole chiave: Tignola orientale del pesco, gestione della resistenza, biosaggi, dip-test
Five new things

Corticobasal syndrome (CBS) is characterized by asymmetric involuntary movements including rigidity, tremor, dystonia, and myoclonus, and often associated with apraxia, cortical sensory deficits, and alien limb phenomena. Additionally, there are various nonmotor (cognitive and language) deficits. CBS is associated with several distinct histopathologies, including corticobasal degeneration, other forms of tau-related frontotemporal lobar degeneration such as progressive supranuclear palsy, and Alzheimer disease. Accurate antemortem diagnosis of underlying pathology in CBS is challenging, though certain clinical and imaging findingsmay be helpful. Five recent advances in the understanding of CBS are reviewed, including clinical and pathologic features, imaging and CSF biomarkers, the role of specific genes, and the concept of a spectrum of tauopathies.
Intracranial Aneurysms

This article reviews the current knowledge of the pathogenesis, clinical features, diagnostic evaluation, and treatment of intracranial aneurysms. The vast majority are acquired lesions, likely as a result of hemodynamic stress on the relatively unsupported bifurcations of the intracranial arteries. Cigarette smoking is an emerging important risk factor for their development. The natural history of unruptured aneurysms is controversial and may be subject to revision. A benign perimesencephalic pattern of subarachnoid hemorrhage has been recognized that usually is not due to a ruptured aneurysm. Current treatment includes surgical clipping and endovascular treatment with Guglielmi detachable coils, which produces comparable results in some instances. Epidemiologic studies suggest that the outcome of patients with aneurysmal subarachnoid hemorrhage remains poor, with a 30-day death rate of 45%, although the outcome of patients who reach the hospital alive may have improved in recent years.
The Effect of Balance Exercises on Knee Instability and Pain Intensity in Patients with Knee Osteoarthritis :A Randomized Clinical Trial

Background and objective: Knee instability is considered as a common symptom in patients suffering from knee osteoarthritis and knee pain. The objective of current research is to examine the effect of balance exercises on knee instability and pain intensity in patients with knee osteoarthritis. Methodology: in this one-blind randomized controlled clinical trial, 30 patients with knee osteoarthritis were selected using simple and convenient sampling method, and they were divided into two groups, including balance exercises group and control group. The treatment program in the balance exercises group included balance exercises, and in the control group, it included ultrasound, TENS(Transcutaneous Electrical Nerve Stimulation), and hot pack. Knee instability was measured according to the evidence of buckling, shifting or giving way through a questionnaire, and the pain intensity was measured by Visual Analogue Scale (VAS) in two periods of before and after treatment. Treatments in both groups lasted for 3 weeks and five times per week. Independent t-test and paired t-test were used for analyzing the data. Results: the mean score of pain and knee instability in the balance group improved from 6.53± 2.32 to 4.60 ± 1.91 (P = 0.00) and from 1.80 ± 0.94 to 2.93 ± 0.79 (P = 0.00), respectively. The mean score of pain and knee instability in the control group improved from7.46± 1.92 to 5.40± 2.09(P=0.00) and from 1.40 ± 0.73 to 2.13 ± 1.06 (P = 0.01), respectively. Significant difference was found between the two groups in terms of mean score of knee instability (P <0.05). Conclusion: inter-group comparison revealed significant difference between balance exercises group and the control group in terms of impact on mean score of knee instability. Intra-group comparison also revealed that mean score of pain and knee stability improved in both of the balance exercises group and control group.
Black flies in the boreal biome, key organisms in both terrestrial and aquatic environments: A review1

Abstract: The boreal biome is rich in running waters suitable for the development of black flies. Here we review the ecological roles of black flies and the options available for their management. Large numbers of these insects play quantitatively important roles in a number of processes, not only in the running-water habitats of the larvae but also in the terrestrial environments of the adults. Black flies suck blood from mammals, including humans, and from birds, with negative effects including occasional death of animals. Black flies also transmit parasites, including filarial worms and haemosporidians. In the last two decades, programs to control black flies by treating the larvae, using Bacillus thuringiensis var. israelensis, have been developed, with predominantly positive results but with limited understanding of the indirect impacts to the aquatic and terrestrial ecosystems. On a more positive side, adult black flies are food for a variety of predators and may favour pollination, as well as helping in nature conservation by deterring people from visiting wilderness areas. Black fly larvae feed on suspended particles, linking this energy source to invertebrate and vertebrate predators (e.g., salmonids). Because larval densities often are high, considerable amounts of sedimenting faecal pellets increase the local retention of organic material, and this provides nutrition for invertebrates and micro-organisms, and potentially fertilizes river margins. Larvae also produce silk, the role of which in the ecosystem is poorly known but potentially important.
Smooth muscle cells; Subarachnoid hemorrhage Arterial vasospasm is the major cause of disability and death in patients with subarachnoid hemorrhage (SAH) subsequent to rupture of cerebral aneurysms

THE OXIDIZED BREAKDOWN products of hemoglobin are important in the pathogenesis of cerebral vasospasm because of their effects on the endothelium and the smooth muscle of the arterial wall. Cytoskeletal changes in cultured vascular cells are sensitive indicators of oxidative injury. Cultured endothelial cells and smooth muscle cells showed a dose-related disruption of the cytoskeleton, particularly the F-actin and vimentin filaments, when exposed to 10 -5 M oxyhemoglobin. The cytoskeletal injury was prevented by the addition of 10-3 M deferoxamine or 1% albumin. These experiments support a role for deferoxamine in the pharmacological treatment of vasospasm. Furthermore, cytoskeletal studies of cultured arterial endothelial and smooth muscle cells provide a novel in vitro approach by which to study the cellular mechanisms of oxidant injury initiated by the breakdown products of hemoglobin.
Analysis of the distribution of charged residues in the N‐terminal region of signal sequences: implications for protein export in prokaryotic and eukaryotic cells.

A statistical analysis of the distribution of charged residues in the N‐terminal region of 39 prokaryotic and 134 eukaryotic signal sequences reveals a remarkable similarity between the two samples, both in terms of net charge and in terms of the position of charged residues within the N‐terminal region, and suggests that the formyl group on Metf is not removed in prokaryotic signal sequences.
S100b protein in peripheral blood may predict progressive disease during interleukin-2 based immunotherapy in patients with metastatic melanoma

The aim of this study was to evaluate the biological variation in the serum level of S100b protein in untreated patients with metastatic melanoma and to use this variation to subsequently evaluate serum levels as a method of monitoring objective response to interleukin-2 (IL2) based treatment. Such an approach has not, to our knowledge, been published previously. Consecutive blood samples were collected before, during and after treatment and in the follow-up period from 66 patients treated with IL2-based immunotherapy. In 11 of these patients, a further three samples were drawn on each of 3 days prior to treatment to evaluate the variation in S100b. This variation was later used to distinguish between increased, unchanged or decreased S100b levels during treatment. We observed a significant association between changes in S100b levels and clinical outcome after the first and second treatment cycles. All responding patients had a decline in S100b levels or normal values during the first cycle. Changes in S100b levels after the first cycle and the type of treatment were independent predictive factors for the clinical outcome in multivariate analysis. In conclusion, increasing S100b values were independently associated with progressive disease, and our data suggest that significant changes in S100b levels may be valuable for monitoring and predicting clinical outcome during IL2-based immunotherapy and chemoimmunotherapy. Melanoma Res 14:211–215 c 2004 Lippincott Williams & Wilkins.
vancomycin-resistant E. faecium with linezolid in a 7-month- old preterm infant. This infant received linezolid in a dosage

old preterm infant. This infant received linezolid in a dosage of 10 mg/kg every 8 h. CSF was sterile at 48 h of treatment. He completed a 21-day course of therapy with no reported adverse event. Several reports have reflected the increased VRE colonization or VRE infections in neonatal intensive care unit patients both in the US and abroad. Antecedent use of vancomycin and extended spectrum cephalosporins have been associated with colonization with VRE and increased risk of developing invasive disease. 15 Nosocomial outbreaks of VRE infections have been linked to contaminated objects or person-to-person transmission by health care workers. Traditionally mortality from enterococcal infections in neonates had been low 2 because of the appropriate use of effective antibiotics and the focal nature of these infections such as soft tissue abscesses or central venous catheterrelated infections that were amenable to surgical drainage or catheter removal that helped in infection resolution. As strains of multidrug-resistant isolates emerged, infections caused by these organisms have become increasingly more difficult to treat. Therapy of invasive VRE infections (mostly E. faecium) is particularly difficult because these organisms are also resistant to multiple antibiotics such as beta-lactams and aminoglycosides. Linezolid is the first member of a new class of antibiotics known as the oxazolidinones. It is active against Grampositive microorganisms including multidrug-resistant isolates. It inhibits protein synthesis by binding to bacterial 23S ribosomal RNA. Time kill studies have shown that linezolid is bacteriostatic against enterococci. Recent multilaboratory assessment of the spectrum of activity of linezolid revealed that it was active against 96% of the 163 VRE isolates. Despite the bacteriostatic activity of linezolid against enterococci, successful treatment of invasive VRE infections with linezolid in adult patients has been reported including VRE meningitis, VRE bacteremia, 9 VRE peritonitis, VRE osteomyelitis and VRE endocarditis. 7 Linezolid given intravenously followed by oral therapy resulted in bacteriologic cure of VRE endocarditis in our infant patient. Linezolid appears to be an attractive choice for the treatment of endocarditis caused by linezolid-susceptible VRE. However, further studies are needed to confirm linezolid efficacy and determine treatment duration.
Receptor polymorphisms and non-classical immune stimuli in bacterial immune recognition

Receptor polymorphisms and non Receptor polymorphisms and non Receptor polymorphisms and non Receptor polymorphisms and non-classical immune classical immune classical immune classical immune stimuli in bacterial immune recognition stimuli in bacterial immune recognition stimuli in bacterial immune recognition stimuli in bacterial immune recognition Receptor polymorphisms and non Receptor polymorphisms and non Receptor polymorphisms and non Receptor polymorphisms and non-classical immune classical immune classical immune classical immune stimuli in bacter stimuli in bacter stimuli in bacter stimuli in bacterial immune recognition ial immune recognition ial immune recognition ial immune recognition me with this projekt, for the continous support and confidence in my work. Especially the enthusiastic and helpfull character of the supervision by Corinna Hermann had always granted the motivation throughout the time. The critical reading of the manuscript by her was of great help. I thank Prof. Dr. Albrecht Wendel for welcoming me into the group, for his support and his engagement in the " International Research Training Group IRTG 1331. " I am grateful for the excellent working facilities provided at the Chair of Biochemical Pharmacology and for the opportunities I had to attend conferences, courses and transfer projekts. I am indebted to the Deutsche Forschungsgesellschaft (DFG) for financial support. I thank all co-authors and collaborators for their valuable contributions to this work, concerning chemical analysis. ACKNOWLEDGEMENTS III Special appreciation is owed our technical right hands Leonardo Cobianchi for numerous LTA preparations and Margarete Kreuer-Ullmann for organizing the murine experiments, as well as all the indispensable blood donors both from the Uni Konstanz and from the IBD patients' collective. Sincere thanks I give to the whole team for the practical and mental support, for the bright working atmosphere and unforgettable times in-and outside the lab. Finally, I want to acknowledge the all-round support by my parents and the readiness of my wife Netti to ceaselessly taking great care of our sons. Major parts of this thesis are published or submitted for publication. stronger toll-like receptor 4-triggering than TNF-a possible explanation for the selective effects of heterozygous TLR4 polymorphism Asp(299)Gly on IL-10 release. Immunobiol 2008; in press. ► O. Dehus, G. Rogler and C. Hermann: LPS-inducible anti-inflammatory responses are not diminished in Crohn's disease patients with heterozygous Asp(299)Gly polymorphism. Submitted to IBD. ► O. Dehus, T. Hartung and C. Hermann: Endotoxin evaluation of eleven lipopolysaccharide by whole blood assay does not always correlate with Limulus Amebocyte Lysate assay. immunogenicity of …
b1-Adrenergic receptor polymorphisms and left ventricular remodeling changes in response to b-blocker therapy

Results Among patients with the Arg389Arg genotype, ejection fraction (EF) increased from 23±5 to 29±10 (P=0.008). Gly389 carriers did not demonstrate any significant change in EF (22±9 to 23±11; P=0.45). There was a significant between-group difference in EF by genotype (P=0.04). The Arg389Arg genotype was also associated with significantly greater reductions in LV end-diastolic and end-systolic diameters compared to Gly389 carriers. Patients with the Gly49 variant also had a significantly greater reduction in LV end-diastolic diameter compared to Ser49 homozygotes. Multiple regression analysis modeling revealed that the codon 389 polymorphism was a significant predictor of an improvement in EF and both codon 49 and 389 polymorphisms were significant predictors of final LV end-diastolic diameter.
Successful ABO Incompatible Kidney Transplant After an Isolated Intestinal Transplant

Claudio Ponticelli Maurizio Salvadori Maria Piera Scolari Franco Citterio Paolo Rigotti Antonella Veneziano Marta Bartezaghi on behalf of EVEREST Study 1 Division of Nephrology Humanitas Scientific Institute Rozzano (Milano), Italy 2 Division of Nephrology Careggi Hospital Firenze, Italy 3 Renal Transplant Unit S. Orsola Malpighi University Hospital Bologna, Italy 4 Department of Surgery Catholic University Hospital Roma, Italy 5 Surgery Division Policlinic University Hospital Padova, Italy 6 Medical Department Novartis Italy Origgio (Varese), Italy
FOCUS ON OBESITY AND WEIGHT MANAGEMENT

The study and practice of obesity has expanded almost as rapidly as the prevalence of obesity. While ongoing hypothesis testing and interim research findings increase our general obesity knowledge, clinical practice and the public demand immediate answers and guidance with the best evidence of the moment. As we examine the effectiveness of obesity treatments, clinical practitioners continue to be challenged in choosing the best evidence to support their interventions. At the same time, both research questions and practical application of study findings are shaped within the psychological and social context of public concerns and interests, which are often fueled by the media and the marketplace.
Betreuung von Neugeborenen diabetischer Mütter. Leitlinie der GNPI, DGPM, DDG, DGHWi, dem DHV, der DGKJ und DGGG. (2k-Level, AWMF-Leitlinien-Register Nr. 024/006, Juli 2017)

stimmten und konsentierten Entwurfs wurde der Text in einer vom Vorstand der GNPI einberufenen Delphi-Konferenz weiterentwickelt. Der 1. Entwurf wurde am 6.9. 2016 elektronisch zugestellt. Änderungsvorschläge konnten binnen 8 Wochen an den Leitlinienbeauftragten eingereicht werden. Diese Vorschläge wurden von den Autoren beraten und daraufhin am 19.3. 2017 eine überarbeitete Fassung mit einer Stellungnahme zu den Änderungsvorschlägen erneut an alle Teilnehmer der Delphikonferenz geschickt, die in der zweiten Runde ihre Änderungsvorschläge offen äußerten. Der neue Entwurf erhielt nach redaktionellen Überarbeitungen die Zustimmung aller 32 abgegebenen Voten aus der Delphi-Konferenz. Die Leitlinie wurde vom Vorstand der GNPI am 7.6. 2017 verabschiedet und erhielt in den folgenden 6 Wochen die Zustimmung der anderen beteiligten Fachgesellschaften.
Visceral, in£ammatory and neuropathic pain in glycine receptor alpha 3-de¢cient mice

The a3-subunit of strychnine-sensitive glycine receptors is an important modulator of the pain-sensitizing e¡ects of spinal prostaglandin prostaglandin E2. Mice de¢cient for a3-subunit of strychnine-sensitive glycine receptors lack the prostaglandin E2-induced inhibition of glycinergic neurotransmission and recover faster from in£ammation-induced hyperalgesia. It, however, remains unclear whether a3-subunit of strychnine-sensitive glycine receptors plays a role in other pain models involving prostaglandin synthesis, such as chemically induced pain or neuropathic pain. In this paper, we show a reduction of acetic acid-induced writhing responses in the absence of a3-subunit of strychnine-sensitive glycine receptors, but no changes in formalin-induced pain. Furthermore, a3-subunit of strychninesensitive glycine receptors-de¢cient mice develop normal thermal hyperalgesia and tactile allodynia.Thus, a3-subunit of strychninesensitive glycine receptors is involved in themodulation of moderate in£ammatory acetic acid-induced pain responses, but neither in formalin-induced pain nor in neuropathic pain. NeuroReport 16:2025^2028 c 2005 LippincottWilliams &Wilkins.
OPENING OF MITOCHONDRIAL POTASSIUM CHANNELS

Background. This study was designed to assess the protective effects of the mitochondrial adenosine triphosphate-sensitive potassium channel (K ATP ) opener diazoxide as an additive to heart preservation solution. Methods. Forty isolated isovolumic buffer-perfused rat hearts were divided into four groups. Groups I and III hearts were arrested with and cold-stored in Celsior solution for 4 hr and 10