Miracle-dz/UniFAR-FTUs huggingface dataset:
Caregiver identity in care partners of persons living with mild cognitive impairment

Research on caregiver identity in the context of memory impairment has focused primarily on more advanced stages of the cognitive impairment trajectory (e.g., dementia caregivers), failing to capture the complex dynamics of early caregiver identity development (e.g., MCI; mild cognitive impairment caregivers). The aim of this study was to develop a nuanced understanding of how caregiver identity develops in family and friends of persons living with MCI. Using constructivist grounded theory (ConGT), this study explored caregiver identity development from 18 in-depth interviews with spouses (n = 13), children (n = 3), and friends (n = 2) of persons recently diagnosed with MCI. The overarching themes influencing MCI caregiver identity development included MCI changes, care-related experiences, “caregiver” interpretation, and approach/avoidance coping. These themes influenced how participants primarily identified, represented as I am a caregiver, I am not a caregiver, or liminality (i.e., between their previous identity and a caregiver identity). Irrespective of their current self-identification, all conveyed thinking about their “future self,” as providing more intensive care. MCI caregiver identity development in family and friends is a fluid and evolving process. Nearly all participants had taken on care tasks, yet the majority of these individuals did not clearly identify as caregivers. Irrespective of how participants identified, they were engaging in care, and would likely benefit from support with navigating these changes and their new, ambiguous, and evolving roles.
MRI Compatible, Customizable, and 3D-Printable Microdrive for Neuroscience Research

Abstract The effective connectivity of brain networks can be assessed using functional magnetic resonance imaging (fMRI) to quantify the effects of local electrical microstimulation (EM) on distributed neuronal activity. The delivery of EM to specific brain regions, particularly with layer specificity, requires MRI compatible equipment that provides fine control of a stimulating electrode’s position within the brain while minimizing imaging artifacts. To this end, we developed a microdrive made entirely of MRI compatible materials. The microdrive uses an integrated penetration grid to guide electrodes and relies on a microdrilling technique to eliminate the need for large craniotomies, further reducing implant maintenance and image distortions. The penetration grid additionally serves as a built-in MRI marker, providing a visible fiducial reference for estimating probe trajectories. Following the initial implant procedure, these features allow for multiple electrodes to be inserted, removed, and repositioned with minimal effort, using a screw-type actuator. To validate the design of the microdrive, we conducted an EM-coupled fMRI study with a male macaque monkey. The results verified that the microdrive can be used to deliver EM during MRI procedures with minimal imaging artifacts, even within a 7 Tesla (7T) environment. Future applications of the microdrive include neuronal recordings and targeted drug delivery. We provide computer aided design (CAD) templates and a parts list for modifying and fabricating the microdrive for specific research needs. These designs provide a convenient, cost-effective approach to fabricating MRI compatible microdrives for neuroscience research.
Does aluminum exposure affect cognitive function? a comparative cross-sectional study

Objectives This study assessed the cognitive function of aluminum-exposed participants from an alum mining zone, compared them with unexposed subjects, and aimed to elucidate the effect of aluminum exposure on cognition. Design This was a comparative cross-sectional study. Univariate analyses were used to assess the differences between the aluminum-exposed and unexposed groups. Binary logistic regression models were applied to analyze the effect of aluminum exposure. Setting The aluminum-exposed participants were included from an alum mining zone and the unexposed subjects were residents from another district without alum-mine-related factories. Participants We included 539 aluminum-exposed participants (254 men, 285 women) and 1720 unexposed participants (692 men, 1028 women). Results The mean cognition score on Mini-Mental State Examination was 21.34 (± 6.81) for aluminum-exposed participants. The exposed group had 6.77 times (95% confidence interval, 5.09–9.00) more risk of cognitive impairment than the unexposed group, after adjusting for age, sex, and educational level. No statistically significant association was found between exposure duration and cognition. Conclusions This study demonstrated a significant association between aluminum exposure and lower cognitive function.
Media Use and Men’s Approval of Intimate Partner Violence in Honduras

Intimate partner violence (IPV) is a widespread issue that affects millions of individuals each year. Prior research suggests that IPV approval is associated with an increased likelihood of IPV perpetration. However, scant research has examined predictors of IPV approval, and even less has examined the predictors of IPV approval in Latin America. Social cognitive theory describes the acquisition of ideas, values, attitudes, and behaviors through social observation, including through media. This study uses social cognitive theory to examine the effects of media use on men’s approval of IPV in Honduras, while controlling for demographic variables and IPV risk factors. We hypothesized that greater engagement with media (via television, radio, and newspapers or magazines) would be associated with decreases in the approval of IPV. Using ordinal logistic regression, we analyzed data from the Men’s Survey Module of the 2011–2012 Honduras Demographic and Health Survey. The final sample included 4,760 currently partnered men. Results suggest that listening to the radio one or more times per week was associated with greater IPV approval, while newspaper/magazine and television use were not significantly associated with IPV approval. Education, marital status, increased age at first cohabitation, and having a female partner or someone else making decisions about earnings were all protective against IPV approval. Further investigation into the content of Honduran radio and other media is called for in order to inform interventions to reduce acceptance of IPV.
Kinetics of the dehydration of methylene glycol in aqueous solution

Methods are described for measuring the velocity of the reaction CH2(OH)2 → CH2O+H2O in aqueous solution by making use of the rapid reaction of unhydrated formaldehyde with the scavenging reagents semicarbazide, hydroxylamine, phenylhydrazine, hydrazine and sulphite. The reaction exhibits general acid-base catalysis, and catalytic constants are given for 14 acids and 30 bases. Relations between acid-base strength and catalytic power extend over an unusually wide range of velocities and types of catalyst, and this behaviour is discussed in terms of reaction mechanisms. The catalytic behaviour observed shows unexpected contrasts with that reported for the hydration of carbon dioxide. It is shown that, contrary to previous reports, the rate of removal of formaldehyde from aqueous solution by a gas stream is not appreciably affected by the rate of dehydration of methylene glycol. A few experiments are reported on the application of the chemical scavenger method to measure the rate of the reaction CH3CH(OH)2 → CH3CHO+H2O, and the results compared with those obtained by other methods.
Neovascular glaucoma - A review

Neovascular glaucoma (NVG) is a sight-threatening secondary glaucoma characterized by appearance of new vessels over the iris and proliferation of fibrovascular tissue in the anterior chamber angle. Retinal ischemia is the common driving factor and common causes are central retinal vein occlusion, proliferative diabetic retinopathy, and ocular ischemic syndrome. The current rise in the prevalence of NVG is partly related to increase in people with diabetes. A high index of suspicion and a thorough anterior segment evaluation to identify the early new vessels on the iris surface or angle are essential for early diagnosis of NVG. With newer imaging modalities such as the optical coherence tomography angiography and newer treatment options such as the anti-vascular endothelial growth factor, it is possible to detect retinal ischemia early, tailor appropriate treatment, monitor disease progression, and treatment response. The management strategies are aimed at reducing the posterior segment ischemia, reduce the neovascular drive, and control the elevated intraocular pressure. This review summarizes the causes, pathogenesis, and differential diagnoses of NVG, and the management guidelines. We also propose a treatment algorithm of neovascular glaucoma.
Psychology in an Indeterminate World

By sharing their world, humans and other animals sustain each other. Their world gets determined over time as generations of animals act in it. Current approaches to psychological science, by contrast, start from the assumption that the world is already determined before an animal’s activity. These approaches seem more concerned with uncertainty about the world than with the practical indeterminacies of the world humans and nonhuman animals experience. As human activity is making life increasingly hard for other animals, this preoccupation becomes difficult to accept. This article introduces an ecological approach to psychology to develop a view that centralizes the indeterminacies of a shared world. Specifically, it develops an open-ended notion of “affordances,” the possibilities for action offered by the environment. Affordances are processes in which (a) the material world invites individual animals to participate, while (b) participation concurrently continues the material world in a particular way. From this point of view, species codetermine the world together. Several empirical and methodological implications of this view on affordances are explored. The article ends with an explanation of how an ecological perspective brings responsibility for the shared world to the heart of psychological science.
Cardiac amyloidosis‐A review of current literature for the practicing physician

The amyloidoses are a family of diseases in which misfolded precursor proteins aggregate to form amyloid and deposit in body tissues. A very serious yet underrecognized form of this disease is cardiac amyloidosis, in which amyloid deposits into the extracellular space of the myocardium, resulting in thickening and stiffening of ventricular walls with resultant heart failure and conductive dysfunction. This review provides a discussion of the pathogenesis and clinical presentation of cardiac amyloidosis subtypes, as well as an up‐to‐date approach to diagnosis and treatment. Significant progress has been made in recent years regarding diagnosis and treatment of this condition, but prognosis remains heavily reliant on early detection of the disease. Two types of precursor protein are responsible for most cardiac amyloidosis cases: transthyretin amyloid, and immunoglobulin‐derived light chain amyloid. An early diagnosis of cardiac amyloidosis can allow for novel treatment modalities to be initiated with the potential to improve prognosis.
Integrating behavioral health services at employer-sponsored health clinics: A descriptive analysis.

INTRODUCTION Approximately, 20% of adults in the United States have a behavioral health concern, resulting in $732M in direct medical spending and over 5 million lost workdays annually. Employers bear a substantial share of these costs. The objective of this study was to describe the integration of behavioral health services at employer-sponsored health clinics. METHOD Retrospective cohort analysis of patients seen for individual behavioral health services from 1/1/2018 to 12/31/2018 in employer-sponsored clinics. RESULTS Among the 2,954 patients cared for by a behavioral health provider, 49% met criteria for moderate or severe depression and/or anxiety. The median duration between appointment scheduling and a behavioral health triage visit was 2 days (SD = 7.2 days), and median interval to an initial psychotherapy visit was 10 days (SD = 14 days). The mean number of visits with a behavioral health provider within the initial 3 months after presenting for care was 5.3 visits (SD = 2.8 visits). During the course of treatment, anxiety (Generalized Anxiety Disorder-7 [GAD-7] scores) decreased by 31% and depression (Patient Health Questionnaire-9 [PHQ-9] scores) decreased by 24%. Patient satisfaction with their behavioral health care was excellent. DISCUSSION Integrating behavioral health services into employer-sponsored clinics can result in timely access to psychotherapy, improvements in clinical symptoms, and excellent patient satisfaction. Employers interested in providing greater access to behavioral health care should evaluate integrating such services into onsite or near-site health clinics. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
Preliminary assessment of viral metagenome from cancer tissue and blood from patients with lung adenocarcinoma

In this study, using a viral metagenomic method, we investigated the composition of virome in blood and cancer tissue samples that were collected from 25 patients with lung adenocarcinoma. Results indicated that virus sequences showing similarity to human pegivirus (HPgV), anellovirus, human endogenous retrovirus (HERV), and polyomavirus were recovered from this cohort. Three different complete genomes of HPgV were acquired from the blood samples and one complete genome of polyomavirus was determined from the cancer tissue sample. Phylogenetic analysis indicated that the three HPgV strains belonged to genotype 3 and the polyomavirus showed the highest sequence identity (99.73%) to trichodysplasia spinulosa‐associated polyomavirus. PCR screening results indicated that the three HPgVs were present in 5 out of the 25 blood samples and the polyomavirus only existed in a cancer tissue sample pool. Whether infections with viruses have an association with lung cancer needs further study with a larger size of sampling.
Torpor versus interbout arousal: what is more important for protein metabolism and regeneration?

Hibernation is usedby specie as diverse as ground squirrels, snakes and bats to cope with reduced food availability and lowered temperatures and is a unique model for studying the molecular mechanisms of plasticity in striated muscles. Important questions in modern muscle biology are why some skeletal muscles atrophy and other muscles such as the diaphragm and the heart hypertrophy during hibernation, and why, despite the atrophy, skeletal muscle strength and fatigue resistance are maintained after arousal. The molecular mechanisms responsible are of interest both from a fundamental biological viewpoint and as a potential therapy for patients in critical care units. In this issue of Experimental Physiology, Yan et al. (2021) shed light on the distinctive features of the molecular mechanisms involved in the development of the hypertrophic response in the diaphragm and the atrophic response in the gastrocnemius muscle in hibernating Daurian ground squirrels. In particular, the authors showed that a decrease in protein synthesis, an increase in protein degradation and a decrease in muscle regeneration potential contributed to the atrophy of the gastrocnemius muscles during torpor, while an increase in protein synthesis, a decrease in protein degradation and an increase in muscle regeneration potential contributed to diaphragmmuscle hypertrophy. In discussing these new and interesting results, it can be assumed, however, that a significant contribution to the formation of hypertrophic or atrophic muscle phenotype could have been made by changes in anabolic and catabolic processes occurring in interbout arousals, as indicated by the results of recent studies (Chang et al.,
Consultation between forensic and clinical pathologists for histopathology examination after forensic autopsy

The magnitude of the diagnostic benefit conferred by performing histopathological examinations after medico-legal/forensic autopsies remains debatable. We have tried to address this issue by reviewing a series of histopathology referrals concerning medico-legal autopsies in real-world routine practice. We present an audit of the consultations provided to forensics by clinical pathologists at our institute between 2015 and 2018. Over this period, 493 post-mortem examinations were performed by forensic pathologists. Of these cases, 52 (11%) were referred for histopathology. Gross assessment was requested in 22/52 (42%) cases. Histopathology examination was performed on single organs in 15/52 (29%) cases, primarily on the lung and heart, whereas parenchymatous multi-organ analysis was carried out in 14/52 (27%) cases. Bone-marrow sampling was studied in 4/52 (8%) cases. Immunohistochemistry was needed in 16/52 (31%) cases, special stains in 9/52 (21%) cases and molecular analysis in 4/52 (8%) cases. Focusing on technical processes, standard methodology on pre-analytical procedures was changed in 10/52 (19%) cases in order to answer specific diagnostic questions. We showed that although most of the time the diagnosis is clear by the end of dissection on the basis of the macroscopic findings, histopathology can provide, modify or confirm the cause of death in many medico-legal/forensic cases. Therefore, it is desirable that forensic pathologists and clinical pathologists establish robust working relationships in a cooperative environment. We conclude that it is important to implement guidelines based on real-world routine practice in order to identify cases where histopathology can provide useful contributions, which in our experience applied to 11% of forensic cases.
Percutaneous Implantation of Adult Sized Stents for Coarctation of the Aorta in Children ≤20 kg

Supplemental Digital Content is available in the text. Background: Stent implantation (SI) is more effective than balloon angioplasty for the treatment of coarctation of the aorta (CoA). Due to technical factors, balloon angioplasty is more commonly performed in small patients. We sought to evaluate outcomes of percutaneous adult sized SI for the treatment of CoA in small patients. Methods: A single-center retrospective review of all patients ≤20 kg who underwent percutaneous adult sized SI for native or recurrent CoA from 2004 to 2015 was performed. Results: Thirty-nine patients (20 patients ≤10 kg) were identified, with 28 (71.8%) having recurrent CoA and 22 (56.4%) previously failed balloon angioplasty. At the time of SI, the median (range) patient age and weight were 1.1 (0.3–7.9) years and 10 (5.5–20.4) kg, respectively. SI resulted in significant improvements in the median gradient (26 mm Hg [interquartile range (IQR), 18–42] to 0 mm Hg [IQR, 0–2]; P< 0.05) and median minimum diameter (3.6 mm [IQR, 2.4–4.8] to 7.7 mm [IQR, 6.5–9.4]; P<0.05). Seven patients (18%) had procedural adverse events. Twenty-seven (69%) patients underwent elective reintervention at a median time of 49.3 (IQR, 26.5–63.2) months from SI, with 8 (21%) stents requiring repeat SI for stent fracture. Over a median follow-up of 67.2 (IQR, 33.8–116.1) months, 25 patients (69%) were without hypertension or blood pressure gradient. Three (11%) patients developed femoral arterial occlusion. Conclusions: Adult sized SI is an alternative to surgical intervention for small patients with CoA. SI carries a risk of access-related complications, which may improve with the development of lower profile stents with adult sized maximum diameters.
Generosity in dictator game and social value orientation predicted the type of costly punishment in ultimatum game.

The current study investigated two types of punishment (prosocial and proself punishment) in the ultimatum game (UG) and examined the impact of individuals' prosocial orientation on the costly punishment in the UG in a representative sample of Chinese undergraduate students (N = 344). The prosocial orientation was measured with individuals' performance in the dictator game (DG), social value orientation (SVO), and the personal norm of reciprocity. Prosocial and proself punishers were established with responses in advantage and disadvantage offers in the UG. Results showed that prosocial and proself punishers coexisted in the UG, and prosocial punishers were more likely to be prosocial in SVO and allocated more resources to the recipient in the DG than proself punishers, but differences in positive/negative reciprocity between prosocial and proself punishers were not found. Further regression analysis found that SVO type and generosity in the DG could predict the type of punishers in the UG, but not positive/negative reciprocity. These findings indicate that individuals rejecting unfair offers in the UG may be motivated by either prosocial motivation with strict fairness concern (prosocial punishment) or selfish motivation with maximizing self-interest concern (proself punishment). Moreover, SVO type and generosity in the DG might be effective measures to discriminate prosocial and proself punishers in the UG.
Effects of calcium deficiency on nutrient concentration of xylem sap of excised tomato plants

Abstract The effects of calcium (Ca) deficiency on cation uptake and concentration of xylem sap from tomato roots after excision of the aerial parts, were studied. The measurements were made on tomato plants grown on nutrient solutions with +Ca or without‐Ca, over a period of 48 hours. Calcium deficiency entailed a significant increase of the flux of xylem sap between the 6th and 14th hour on the first day after excision. In spite of the lack of Ca in the nutrient solution, the Ca concentration in xylem sap was unaffected in regard to that of excised roots with +Ca. The maintenance of the Ca concentration in xylem sap of plants grown on a Ca deficient solution was related to a reuse of the Ca from the apoplastic root stores. So, this regulation indicates a possible translocation of the Ca available in the root supply and a mobility of this element out of the roots only during the early stages of exposure to a Ca deficiency. The presence of NH4 + in xylem sap with both +Ca and‐Ca treatments confirms the nitrogenous reduction activity of tomato roots. The accumulation of free ammonium 24 h after excision in both xylem saps (+Ca and‐Ca) is likely to be evidence of an alteration process of protein synthesis which is related to the depletion of the root water soluble carbohydrate supply.
Role of transforming growth factor‐β1 in recessive dystrophic epidermolysis bullosa squamous cell carcinoma

Squamous cell carcinoma (SCC) develops in more than 80% of individuals with the skin blistering disorder recessive dystrophic epidermolysis bullosa (RDEB). In contrast with UV‐induced SCC, RDEB‐SCC results from skin damage and has a high proliferative and metastatic rate with 5‐year survival near zero. Our objective is to determine the mechanisms underlying the increased metastatic tendencies of RDEB‐SCC. RDEB‐SCC cultured cell lines were treated with RDEB and non‐RDEB fibroblast conditioned media and assayed for migration and invasion with and without small molecule inhibitors for TGFβ and other downstream signal transduction pathways. TGFβ1 secreted by RDEB dermal fibroblasts has been found to induce migration and invasion and to increase expression of epithelial‐to‐mesenchymal transition markers in an RDEB‐SCC line. These effects were reversed upon inhibition of TGFβ signalling and its downstream pathways MEK/ERK, P38 kinase and SMAD3. A number of small molecule inhibitors for these pathways are in different phases of various clinical trials and may be applicable to RDEB‐SCC patients. Studying the mechanisms of the extreme form RDEB‐SCC may inform studies of other types of SCC, as well as lead to better therapies for RDEB patients.