Miracle-dz/UniFAR-FTUs huggingface dataset:
The Combined Effect of Regular Aerobic Exercise with Garlic Extract on Renal Apoptosis Regulatory Factors in Aged rats with Chronic Kidney Disease

Background: Chronic kidney disease as an important risk factor is associated with some disorders which are key causes of death and disability in older people. Therefore, the aim of this study was to assess the combined effect of regular aerobic exercise with garlic extract on renal apoptosis regulatory factors in aged rats with chronic kidney disease. Materials and Methods: In this experimental research, 42 aged male Wistar rats(48-52 weeks) were selected and randomly divided into 6 groups: control, doxorubicin, doxorubicin-salin, doxorubicin- garlic, doxorubicin - exercise, doxorubicin –garlic-exercise(combined). Chronic kidney disease was induced by a single subcutaneous injection 8.5 mg/kg of doxorubicin. Swimming training was programmed 3 days /week, 30 min/day for 8 weeks. Both the doxorubicin garlic and combined groups with garlic extract were administered by garlic gavage at a dose of 2.5 g/kg. The renal Bax and Bcl-2 levels were evaluated by ELIZA method. A one-way analysis of variance was used to data analysis (p<0.05). Results: The results showed that induced chronic kidney disease was associated with a significant increase on Bax and a decrease on Bcl-2 in aged rats. Also, 8 weeks swimming training, garlic supplementation and the combined intervention significantly reversed these changes. Furthermore, no significant difference have been observed in the effect of these interventions on Bax and Bcl-2 in aged rats with chronic kidney disease. Conclusion: It seems that the use of non-pharmacological treatment methods such as exercise training, garlic extract supplement, and combination of the both interventions may be effective in reducing apoptosis resulted from chronic kidney disease in aged rats.
Системы рекомендаций: обзор современных подходов

This paper is a survey of algorithms that are used in recommender systems. All related methods may be divided into three large groups: collaborative filtering, content-based and knowledge-based methods. These approaches are based on different source data that is used for recommendations computing. Collaborative filtering is based on analyzing ratings that user provide for items. The idea here is to recommend items that got high rating by the users that are similar with the user, who receives recommendations from the system. Content-based methods use available content of recommended items. Predominantly the content is represented as texts from items' names, descriptions and so on. Methods that analyze media content (images, videos, audio) are not considered in this paper. Knowledge-based methods analyze user requests that include information about what items do they want. The most popular methods are considered in this paper. Advantages and drawbacks of recommender technics of each group of methods are described. Moreover, composite techniques that allow drawbacks to be eliminated are considered in the paper. Composite technics assume that a lot of information about items is available. Hence, they combine collaborative filtering, content- and knowledge-based technics to provide more accurate recommendations for users.
Perception of occluding contours: Neural mechanisms and a computational model

Recent studies of neuronal responses to illusory contour figures were reviewed and the evidence for a simple bottom-up processing model was discussed. The model is based on the idea that the system infers occluding contours by combining the results of multiple parallel paths of computation, each of which exploits a specific cue. Its basic structure and many details were derived from single cell studies of areas V1 and V2 of the monkey. A computer implementation of the model was shown to predict the appearance and exact shape of various illusory contour figures, as well as the figureground effect. It also generated contour maps on complex natural images that were significantly better than conventional edge maps
Lung Recruitment in Trauma Patients

The ventilatory management of trauma patients can present significant challenges. Its main aims focus on the reduction of the work of breathing, facilitation of an improvement in gaseous exchange, and on the avoidance of ventilation-induced lung injury (VILI). VILI is a pathophysiologic process consisting of several changes seen in ventilated lungs that have been attributed to the ventilation strategy employed subsequent to the traumatic lung injury. In order to avoid the major components of VILI, both maximal alveolar aeration and recruitment are needed to minimize the shear stresses in the injured lung tissue. Alveolar recruitment maneuvers have become the major goals of mechanical ventilatory support for patients with severe trauma over the last few decades. The importance of early lung recruitment with an ‘open lung’ approach has been well documented in several studies and its application has been shown to preserve lung mechanics, attenuate lung mechanotrauma, and thereby reduce mortality during ventilation. Controversies nonetheless exist regarding the most appropriate form of their use in patients with pulmonary injuries as recruitment maneuvers may have several adverse effects. The main concerns center on exploiting high airway pressures during the recruitment process and its potential harmful consequences, such as barotrauma and hemodynamic compromise. The purpose of this article is to review the major concepts in the mechanical ventilation literature that outline the principles for the use of the open lung management strategy in patients that have been subjected to significant trauma and to delineate both the major techniques of lung recruitment as well as their potential complications. Correspondence to: Marcin Karcz, Department of Anesthesiology, University of Rochester Medical Center, 601 Elmwood Avenue, PO Box 604, Rochester, New York, 14642, USA, Tel: +1-585-275-1385; Fax: +1-585-244-727; E-mail: marcin_karcz@urmc.rochester. edu
Das "Kremser Modell": Erfolgreiches Disease-Management zur Betreuung von Patienten mit Herzinsuffizienz

: The “Kremser Model”: Success- ful Disease Management Programme for Patients with Chronic Heart Failure. The prevalence of chronic heart failure is continu-ously increasing, frequent hospital admissions and long hospitalisations due to decompensated heart failure cause rising costs. The aim of this cardiac care project was to test how a disease management programme caring for patients with chronic heart failure in an outpatient clinic with telemonitoring affects medical and eco- nomic parameters. A total of 200 patients from the catchment area of the LK Krems suffering from systolic cardiac insufficiency (left ventricular ejection frac- tion < 40%) were enclosed in the project. The special care group went through a 6- months lasting outpatient treatment. Special care also included education and training, test-(cid:132)(cid:132)(cid:132)(cid:132)(cid:132) of life, it improves measurable outcome parameters and saves costs at the same time. This model experi- enced in the LK Krems could be rolled out on other hospitals in Lower Austria. J Kardiol 2011; 18 (Pre-Publishing Online).
The Influence of Rectal Cisapride on Morphine-induced Gastric Stasis

The effect of a new formulation of the gastric prokinetic agent cisapride on opioid-induced gastric stasis was investigated. Forty patients were randomly allocated to one of four therapies administered as premedication; group A, placebo suppositories only; group B, placebo suppositories and intramuscular morphine 10 mg; group C, rectal cisapride 30 mg and intramuscular morphine 10 mg and group D, rectal cisapride 60 mg and intramuscular morphine 10 mg. Gastric emptying was assessed from the small bowel absorption of paracetamol following oral absorption. The kinetics of the suppository formulation were determined from venous blood samples. Rectal cisapride in the two doses used did not prevent opioid-induced gastric stasis. This may reflect an inability of this formulation to produce adequate plasma concentrations.
Preclinical evaluation of anti-MET antibodies for immunohistochemical staining.

11103 Background: The monovalent anti-MET antibody onartuzumab in combination with erlotinib showed clinical benefit in a phase II trial in advanced non-small cell lung cancer (NSCLC); this benefit was limited to MET-positive tumors as determined by immunohistochemistry (IHC) using the CONFIRM anti-total MET rabbit monoclonal antibody (Ventana). The trial results demonstrate the importance of a reliable IHC assay to distinguish MET-positive from MET-negative cancers. Therefore, it is important to gain a pre-clinical understanding of available antibodies that may warrant further investigation. The aim of this study was to evaluate nine anti-MET antibodies for sensitivity and specificity using various standard staining conditions. Methods: All antibodies were evaluated on eight formalin-fixed paraffin-embedded (FFPE) cell lines with known RNA and protein (ELISA) MET expression levels. Antibodies with adequate sensitivity and specificity were then analyzed on a NSCLC tissue microarray (TMA) and on whole sect.
Padre Agostino Gemelli and the crusade to rechristianize Italy, 1878–1959: Part one

Padre Agostino Gemelli (1878-1959) was an outstanding figure in Catholic culture and a shrewd operator on many levels in Italy, especially during the Fascist period. Yet he remains little examined or understood. Scholars tend to judge him solely in light of the Fascist regime and mark him as the archetypical clerical fascist. Gemelli founded the Università Cattolica del Sacro Cuore in Milan in 1921, the year before Mussolini came to power, in order to form a new leadership class for a future Catholic state. This religiously motivated political goal was intended to supersede the anticlerical Liberal state established by the unifiers of modern Italy in 1860. After Mussolini signed the Lateran Pacts with the Vatican in 1929, Catholicism became the official religion of Italy and Gemelli’s university, under the patronage of Pope Pius XI (1922-1939), became a laboratory for Catholic social policies by means of which the church might bring the Fascist state in line with canon law and papal teachings. Despite Gemelli’s accommodations to the state, he maintained relative autonomy for his university. This allowed the leftwing of postwar Christian Democracy to form at the Università Cattolica during Mussolini’s peak years. Thus, the story of Gemelli is more complex than previous scholars have appreciated. My work attempts to give it the meaningful approximation it deserves. By examining Gemelli’s ties to the Risorgimento, the Italian Catholic movement, and the culture and society of his native Milan, I reveal him as a man of consequence even before the onset of Fascism. I also lay out conditions of possibility for his ascendancy among Catholics after Mussolini came to power. Reducing the complexity of Gemelli’s activity to a manifestation of clerical fascism obscures the fact that he, like many Italian Catholics who formed a consensus of sorts with the Fascist state, retained a cultural, social, and political vision that looked beyond Fascism. The story of Padre Gemelli sheds light on the totalizing worldview of Catholicism that predates political totalitarianism and made it difficult to separate religion entirely from politics in Fascist Italy. Degree Type Dissertation Degree Name Doctor of Philosophy (PhD) Graduate Group History First Advisor Jonathan Steinberg
Anomalie rénale de l'excrétion sodée, un marqueur de la prédisposition héréditaire à l'hypertension artérielle, rôle de la dopamine?

Since Dahl's observation, a renal defect os sodium excretion is proposed as one of pathogenetic mechanism of hypertension (HTA). Our study has tried to verify this concept in 20 young normotensives with (n = 12) and without (n = 8) familial predisposition to HTA, allowing to test the genetic transmission of such potential renal abnormality of sodium balance. Each people was submitted to 3 different Na diet (20, 170 and 340 mM NaCl) each for 1 week. At each visit, blood pressure, vascular resistances, biological values were determined at rest (plasma renin activity, creatinine clearance, 24 hours before the test, catecholamines, aldosterone and ion urinary excretion). Then 1 liter of isotonic saline was perfused in 30 minutes with measures of blood pressure and 3 hours urinary dopamine and Na excretion. During the low and medium Na diets, but not during the high Na diet, the natriuresis and dopamine excretion were lower in the 3 hour urine collection in patients with a family history of HTA (p less than 0.02 and p less than 0.005, respectively). No other clinical or biological difference was noted between the 2 groups. Thus, genetic hypertensive predisposition seems to be characterized by a lower Na excretion during acute Na loading in normal or depleted Na diet, linked to an impaired urinary dopamine excretion. These findings suggest that the defect responsible for the susceptibility to sodium intake is at the kidney level. Some dopamine agonists would be of great therapeutical value in treating such patients when blood pressure begins to rise.
Pro-Inflammatory Cytokines in Sepsis: Biological Studies and Prospects From In Silico Research

Sepsis is one of the leading causes of death in intensive care units (ICUs) and is responsible for thousands of annual deaths worldwide. The pro-inflammatory cytokines are necessary for the control of infection and are the primary focus of this paper. Due to their central role in the pathogenesis of sepsis, more emphasis is needed on the use of cytokine as biomarkers. Implementation of the cytokines in the AutoSimmune for immune system simulations may improve understanding of aspects of the physiopathology of disease in humans. We present the principal aspects of the pathogenesis of the pro-inflammatory response in sepsis and the possibilities of their modulation in order to alter the course of this illness. We highlight the main pro-inflammatory cytokines that may be used as biomarkers in clinical practice. We also discuss the perspectives of sepsis in silico investigation, using the AutoSimmune computational system. Sepsis remains a true challenge in contemporary clinical practice, especially in terms of diagnosis, therapeutics, and prognosis. A greater understanding of inflammation in sepsis – especially in relation to cellular and molecular participation in the development of the morbid process – has the potentiality for the development of new investigative methods and outcome prediction, elements that may aid in offering good patient care.
2007, enquête OPPIDUM: consommations de méthadone et de buprénorphine haut dosage

Les traitements de substitution aux opiaces (TSO) ont ete mis sur le marche au cours des annees 1990 afin de prevenir la survenue de problemes sanitaires decoulant de l'usage d'opiaces illicites. Malgre une amelioration de la situation socio-economique des sujets sous TSO, on a observe des formes de mesusage. L'objectif de l'etude est de comparer les caracteristiques socio-demographiques, les conduites et consommations associees des sujets sous protocole buprenorphine haut dosage (BHD) et methadone inclus dans l'enquete Observation des produits psychotropes illicites ou detournes de leur utilisation medicamenteuse (OPPIDUM) en 2007 ainsi que les modalites de consommations de la BHD et de la methadone consommees sous protocole. Cette etude met en evidence une meilleure insertion sociale des sujets sous methadone par rapport aux sujets sous BHD. Les resultats temoignent aussi de l'existence d'un potentiel de detournement des TSO sous protocole, particulierement la BHD.
A Comparative Study of Nutritional Programmes in Andhra Pradesh

Despite its enormous strides in economic development, India is yet to exhibit similar progress in its human development indicators like nutritional status of its children. In this context, this study examines the two prominent nutritional programs in Andhra Pradesh, namely Integrated Child Development Services operated through Anganwadi Centres (AWCs) and Nutrition cum Day Care Centres (NDCCs) operated by women self help group federations. It points out that the focus in AWCs is disproportionately on children above three years, while 90% of the brain’s growth happens in the first three years. While NDCCs model addresses this issue, the lack of steady flow of funds offsets the commendable nutritional programme in place. In addition, multiple departments handling maternal and child health (MCH) has blurred lines of accountability at the field level. Therefore, this report argues for a restructuring of MCH services by delineating services provided to children above three years and transferring them to education department. Health department could handle the rest of the MCH services, including the nutritional programmes through mothers’ committees. Such an arrangement will restore the focus on children below three years, draw up clear lines of accountability and increase the beneficiary participation in the delivery of MCH services.
Management of diabetes mellitus in patients with type 2 diabetes residing in a rural district of westpomeranian province

WSTĘP. Zdecydowana wiekszośc chorych na cukrzyce typu 2 (ok. 95% wszystkich przypadkow cukrzycy) pozostaje, zwlaszcza na terenach wiejskich, pod wylączną opieką lekarzy rodzinnych. W badaniu UKPDS udowodniono, ze lepsze wyrownanie cukrzycy typu 2 istotnie zmniejsza ryzyko rozwoju przewleklych powiklan cukrzycowych. Celem przedstawionego badania byla ocena wyrownania metabolicznego chorych na cukrzyce typu 2, zamieszkujących gmine rolniczą w wojewodztwie zachodniopomorskim. MATERIAŁ I METODY. Badanie przeprowadzono w Poradni Lekarza Rodzinnego NZOZ „Asklepios” w Bobolicach, pod opieką ktorej pozostaje 279 pacjentow chorych na cukrzyce stanowiących 3,3% zarejestrowanych tam osob. Na badanie zaproszono wszystkich chorych, spośrod ktorych zglosilo sie 249 osob (89%). Wiek badanych wynosil 32-91 lat (śr. 66,5 ± ± 12,4 roku). Wskaźnik masy ciala (BMI) oznaczony u 174 chorych wynosil 32,3 ± 6,4 kg/m 2 . U wszystkich badanych rano, na czczo pobrano krew zylną w celu oznaczenia stezen HbA 1c oraz glukozy. WYNIKI. Średnie stezenie HbA 1c w badanej probie wynosilo 7,82 ± 1,95%, średnie stezenie glukozy na czczo - 156 ± 66 mg/dl. Stezenie HbA 1c wynoszące maksymalnie 6,5% stwierdzono u 31% osob uczestniczących w badaniu. Poządaną glikemie na czczo wynoszącą maksymalnie 110 mg/dl, stwierdzono u 25% chorych. Jedynie u 17% badanych oba parametry, HbA 1c oraz glikemia na czczo, spelnialy kryteria wyrownania wyznaczone przez PTD 2007. Stezenie HbA 1c ponizej 7%, zalecane przez ADA, osiągnelo 38% uczestnikow badania, zaś glikemie na czczo w przedziale 90-130 mg/dl zaobserwowano u 37% badanych. Oba zalecane przez ADA kryteria wyrownania spelnilo 22% chorych. Uzyskane wyniki porownano z danymi pochodzącymi z innych ośrodkow, w ktorych oceniano chorych zamieszkujących miasta. WNIOSKI. Wyrownanie metaboliczne chorych na cukrzyce typu 2 zamieszkujących tereny wiejskie jest niezadowalające i wydaje sie gorsze niz u pacjentow mieszkających w miastach. Byc moze wplywa na to wiekszy stopien otylości i nadwagi obserwowany u tych chorych, a takze mniejsza dostepnośc opieki specjalistycznej.
Examining Service Needs of Trafficked Women From the Former Eastern Bloc: The Canadian Case

This article provides an overview of the health and social service issues relevant to trafficked women sex workers drawn from a phenomenological study that explored the transition processes of women trafficked into Canada from the former Soviet Union and Eastern and Central Europe. The study interviewed 20 female sex workers, 15 health and social service providers, and 15 key informants. The authors challenge the commonly held principle that trafficked/migrant sex workers should receive specialized services in their own language and within their own community, as the study revealed that women would prefer to use existing generic health and social services. (PsycINFO Database Record (c) 2012 APA, all rights reserved). (journal abstract)
Motivation for studying medicine: assessing the similarities between UK and Ghanaian medical students

Countries around the world experience challenges in ensuring equal distribution of health workers. For countries faced with this problem, there are many benefits to international co-operation. Before this can occur, however, there needs to be an understanding of the homogeneity of medical students between countries. This paper assesses the similarities in motivation to study medicine between medical students from the United Kingdom (UK) and Ghana. A survey previously performed on fourth-year Ghanaian students was reproduced with medical students in the UK. Students were asked to record their motivation for studying medicine, opinions on future career [general practice (GP) for UK students and a rural position for Ghanaian students] and basic demographics. The results were compared between the two cohorts using Fisher’s exact test. Of medical students, 302 from Ghana and 78 from UK completed the survey. Of students, 63.5 and 75.0% were classified as intrinsically motivated in Ghana and the UK, respectively. Apart from parental education status, student demographics were broadly similar. Within the UK cohort, 30.1% of students considered it likely that they would work in GP in their future careers. Medical students are similarly motivated between the two countries. This suggests that greater co-operation may be possible when tackling difficulties in human resources for health. This is especially relevant for the UK, as the level of students predicting a career in GP in this study remains well below the national target.
Significant Predictors of Functional Status and Complications in Patients Undergoing Surgery for the Treatment of Cervical Spondylotic Myelopathy

Introduction: Cervical spondylotic myelopathy (CSM) is a degenerative spine disease and the most common cause of spinal cord dysfunction in adults worldwide. Surgery is increasingly recommended as the preferred management strategy for these patients as it can effectively halt neurological progression and improve functional status. In this field, there is an increasing need to manage patients’ expectations of outcomes and inform them of relative risks and benefits of their surgical procedure. Objectives: This thesis aims to identify important predictors of functional outcomes and perioperative complications in patients undergoing surgery for the treatment of CSM. Methods: Three systematic reviews of the literature were performed to identify 1) important clinical predictors of surgical outcome; 2) important imaging predictors of surgical outcome; and 3) significant clinical and surgical predictors of complications. Two surveys were also conducted to evaluate what spine professionals believed were the most critical predictors of functional outcomes and complications. Finally, using prospectively-collected data, we