Miracle-dz/UniFAR-FTUs huggingface dataset:
Commentary: Contextualizing Neuroticism in the Hierarchical Taxonomy of Psychopathology

Dit commentaar bevat belangrijke overwegingen in ons begrip van het verband tussen de persoonlijkheidsdimensie neuroticisme en de ontwikkeling van veelvoorkomende mentale stoornissen vanuit het perspectief van het HiTOP dimensionele model van psychopathologie. Processes op het individuele niveau moeten worden aangetoond om het model substantie te geven.
Invasive yeast infections in the intensive care unit of a tertiary care centre in South India

Introduction: The incidence of invasive mycoses has increased enormously due to the rising population of critically ill patients. Emergence of rare yeasts with variable sensitivity patterns has underlined the need to monitor laboratory data for the emergence of resistance. AIMS: To determine the prevalence and susceptibility patterns of invasive mycoses and analyse the causative risk factors in the Intensive Care Unit (ICU) of a tertiary care centre in South India. Materials and Methods: This is a retrospective, observational study performed on invasive Candida species isolated from patients admitted to the ICU. All the blood and cerebrospinal fluid (CSF) samples from ICU patients, over a period of one year, were included in the study. Preliminary identification of the isolates was done by VITEK. Genotypic identification of each isolate was done using colony polymerase chain reaction-restriction fragment length polymorphism and gene sequencing. Susceptibility pattern was ascertained by broth microdilution method according to the Clinical and Laboratory Standards Institute guidelines in document M27-A3. Relevant clinical details of the patients were collected from the records for the analysis of risk factors and outcome. Results: The present study was done on 4629 blood and 341 CSF specimens, which were sent to the central clinical microbiology laboratory for diagnosis, between November 2013 and October 2014. A total of 49 Candida strains were isolated during the study period, with a prevalence of candidaemia in our ICU to be 1.05%. Candida tropicalis 19 (35.8%) was found to be the predominant species, followed by Candida albicans, Candida parapsilosis, Candida auris, Candida glabrata, Candida duobushaemulonii and Candida krusei. All the Candida species were found to be sensitive to Anidulafungin and Micafungin. Candida isolates were sensitive to Fluconazole - 39 (80.4%), Voriconazole - 49 (100%), Amphotericin B - 27 (54.7%) and Caspofungin - 48 (96.3%). Risk factor analysis revealed intravenous catheterisation as the major predisposing factor, followed by prior therapy with broad-spectrum antibiotics, mechanical ventilation, urinary catheterisation, diabetes mellitus and steroid therapy. Four isolates of Cryptococcus neoformans were also isolated from the blood samples. Three (0.8%) cases of fungal meningitis were diagnosed from 341 CSF samples, with C. tropicalis, C. neoformans and Cryptococcus gattii as causatives. Conclusion: It is of paramount importance to promptly identify and precisely determine the susceptibility of these agents, to combat this medical battle.
Evolving Toward Subject-Specific Gait Rehabilitation Through Single-Joint Resistive Force Interventions

Walking is one of the most relevant tasks that a person performs in their daily routine. Despite its mechanical complexities, any change in the external conditions that applies some external perturbation, or in the human musculoskeletal system that limits an individual's movement, entails a motor response that can either be compensatory or adaptive in nature. Incidentally, with aging or due to the occurrence of a neuro-musculoskeletal disorder, a combination of such changes including reduced sensory perception, muscle weakness, spasticity, etc. has been reported, and this can significantly degrade the human walking performance. Various studies in gait rehabilitation literature have identified a need for the development of better rehabilitation paradigms and have implied that an efficient human robot interaction is critical. Understanding how humans respond to a particular gait alteration can be beneficial in designing an effective rehabilitation paradigm. In this context, the current work investigates human locomotor adaptation to resistive alteration to the hip and ankle strategies of walking. A cable-driven robotic system, which does not add mobility constraints, was used to implement resistive force interventions within the hip and ankle joints separately through two experiments with eight healthy adult participants in each. In both cases, the intervention was applied during the push-off phase of walking, i.e., from pre-swing to terminal swing. The results showed that subjects in both groups adopted a compensatory response to the applied intervention and demonstrated intralimb and interlimb adaptation. Overall, the participants demonstrated a deviant gait implying lower limb musculoskeletal adjustments as if to compensate for a hip or ankle abnormality.
Mechanisms of Pathogenic Candida Species to Evade the Host Complement Attack

Candida species are common colonizers of the human skin, vagina, and the gut. As human commensals, Candida species do not cause any notable damage in healthy individuals; however, in certain conditions they can initiate a wide range of diseases such as chronic disseminated candidiasis, endocarditis, vaginitis, meningitis, and endophthalmitis. The incidence of Candida caused infections has increased worldwide, with mortality rates exceeding 70% in certain patient populations. C. albicans, C. glabrata, C. tropicalis, C. parapsilosis, and C. krusei are responsible for more than 90% of Candida-related infections. Interestingly, the host immune response against these closely related fungi varies. As part of the innate immune system, complement proteins play a crucial role in host defense, protecting the host by lysing pathogens or by increasing their phagocytosis by phagocytes through opsonization. This review summarizes interactions of host complement proteins with pathogenic Candida species, including C. albicans and non-albicans Candida species such as C. parapsilosis. We will also highlight the various ways of complement activation, describe the antifungal effects of complement cascades and explore the mechanisms adopted by members of pathogenic Candida species for evading complement attack.
Value of QRS distortion and ST-segment shift in acute coronary syndrome patients in relation to gensini score

Background: Terminal QRS complex distortion on admission electrocardiography (ECG) has been used to estimate the final infarct size and the prognosis after acute coronary syndrome (ACS); however, it is not sure whether the QRS distortion is more reliable for predicting the severity of coronary artery lesions or not. The Aim of the Work: The aim is to analyze the admission ECG in ACS based on abnormality observed in the terminal QRS complex distortion and ST-segment and its relation to coronary artery lesion severity. Patients and Methods: We included 150 patients presented with ACS. Patients were divided according to the presenting ECG in two major groups, 120 patients presented with ST-segment elevation myocardial infarction (STEMI) who were classified into two groups according the presence or absence of the QRS distortion: 42 patients with +ve QRS distortion (Group I) and 78 patients with −ve QRS distortion (Group II), and 30 patients presented with non-ST-segment elevation (NSTE)-ACS who were also further classified according the magnitude of ST shift by millimeter into three groups. All patients underwent primary percutaneous coronary intervention, and Gensini score defined the severity of coronary artery lesions. Results: In this study, in STEMI patients groups, we observed that QRS distortion on admission, ECG has a significant relationship with high Gensini score values, whereas in NSTE-ACS patients, we demonstrated no significant difference between the extents of ST-segment shift and Gensini score values. Conclusion: QRS distortion has a significant value in predicting severe coronary artery lesions in STEMI patients while the extent of ST-segment shift has no benefits in predicting the severity of coronary artery lesion in NSTE-ACS patients.
Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases

The kidney is a highly metabolic organ and uses high levels of ATP to maintain electrolyte and acid-base homeostasis and reabsorb nutrients. Energy depletion is a critical factor in development and progression of various kidney diseases including acute kidney injury (AKI), chronic kidney disease (CKD), and diabetic and glomerular nephropathy. Mitochondrial fatty acid β-oxidation (FAO) serves as the preferred source of ATP in the kidney and its dysfunction results in ATP depletion and lipotoxicity to elicit tubular injury and inflammation and subsequent fibrosis progression. This review explores the current state of knowledge on the role of mitochondrial FAO dysfunction in the pathophysiology of kidney diseases including AKI and CKD and prospective views on developing therapeutic interventions based on mitochondrial energy metabolism.
Diogenes' syndrome: review and case history

Abstract Our objective in writing this paper was to present a case of Diogenes' syndrome and to examine the evolution of thinking about the phenomenon. To do this we looked at original case material and then carried out a literature review, the results of this showed the syndrome has been reported most often in the elderly and in higher socio-economic groups. It represents a non-specific final common pathway for many interacting variables. In our conclusion we found that a detailed multidisciplinary assessment is indicated in all cases. Further work is required to estimate the role of personality disorder and organic frontal lobe dysfunction in the aetiology of this syndrome. A multiaxial approach to diagnosis should be employed. Intervention should be based on objective findings and risk-assessment, rather than on ideological grounds. Irish law does not allow a large variety of options to the helping professions.
Music2Dance: DanceNet for Music-Driven Dance Generation

Synthesize human motions from music (i.e., music to dance) is appealing and has attracted lots of research interests in recent years. It is challenging because of the requirement for realistic and complex human motions for dance, but more importantly, the synthesized motions should be consistent with the style, rhythm, and melody of the music. In this article, we propose a novel autoregressive generative model, DanceNet, to take the style, rhythm, and melody of music as the control signals to generate 3D dance motions with high realism and diversity. Due to the high long-term spatio-temporal complexity of dance, we propose the dilated convolution to improve the receptive field, and adopt the gated activation unit as well as separable convolution to enhance the fusion of motion features and control signals. To boost the performance of our proposed model, we capture several synchronized music-dance pairs by professional dancers and build a high-quality music-dance pair dataset. Experiments have demonstrated that the proposed method can achieve state-of-the-art results.
Investigation of the Lactic Acid Bacteria in Kazak Cheese and Their Contributions to Cheese Fermentation

Kazak cheese is a traditional dairy product fermented by lactic acid bacteria (LAB) in Xinjiang. To investigate the LAB in Kazak cheese and their contributions to cheese fermentation, four representative LAB, Streptococcus thermophilus B8, Lactobacillus helveticus B6, Weissella confusa B14, and Lactobacillus rhamnosus B10, were isolated from Kazak cheese and subsequently used to ferment cheeses, which were named StC, LhC, WcC, and LrC, respectively. The result showed that most of the physical and chemical indicators had no significant difference, except for moisture and fat. W. confusa B14 was beneficial to the production of amino acids, whereas S. thermophilus B8 promoted the formation of organic acids and contributed to formation ideal texture property. Furthermore, the four cheeses all possessed a strong fruity aroma, with brandy, sweet, herbaceous, pungent, and fatty aromas being the most prominent in WcC. This is because L. helveticus B6 produced a high concentration of hexanal, nonanal, octanal, 3-methylbutanoic acid, ethyl acetate, ethyl butanoate, isoamyl acetate, and ethyl hexanoate in LhC. Research on the fermentation mechanism of LAB in cheese will provide a theoretical basis for the quality control and industrial production of Kazak cheese.
Membrane and luminal proteins reach the apicoplast by different trafficking pathways in the malaria parasite [i]Plasmodium falciparum[i]

The secretory pathway in Plasmodium falciparum has evolved to transport proteins to the host cell membrane and to an endosymbiotic organelle, the apicoplast. The latter can occur via the ER or the ER-Golgi route. Here, we study these three routes using proteins Erythrocyte Membrane Protein-1 (PfEMP1), Acyl Carrier Protein (ACP) and glutathione peroxidase-like thioredoxin peroxidase (PfTPxGl) and inhibitors of vesicular transport. As expected, the G protein dependent vesicular fusion inhibitor AlF4 and microtubule destabilizing drug vinblastine block the trafficking of PfEMP-1, a protein secreted to the host cell membrane. However, while both PfTPxGl and ACP are targeted to the apicoplast, only ACP trafficking remains unaffected by these treatments. This implies that G-protein dependent vesicles do not play a role in classical apicoplast protein targeting. Unlike the soluble protein ACP, we show that PfTPxGl is localized to the outermost membrane of the apicoplast. Thus, the parasite apicoplast acquires proteins via two different pathways: first, the vesicular trafficking pathway appears to handle not only secretory proteins, but an apicoplast membrane protein, PfTPxGl. Second, trafficking of apicoplast luminal proteins appear to be independent of G-protein coupled vesicles.
Hair-Dye induced erythema multiforme like allergic contact dermatitis

Erythema multiforme (EM), originally named by Hebra as erythema exudativum multiforme, is an acute self limiting mucocutaneous condition which is usually diagnosed on the basis of its characteristic clinical features like target shaped papules with a tendency for facial and acral involvement. The most common precipitating factors include viral infections and drugs [1]. EM induced by contact allergy is a rare entity. Here we report a case of EM induced by contact allergy to p-Paraphenylenediamine (PPD), a common colorant present in hair-dyes.
Washing Away Ebola

Summary Emerging infectious diseases are a critical issue in contemporary global environmental health. The 2014/15 Ebola epidemic in West Africa has become the large most widespread outbreak of the disease to date, Among its various impacts, the epidemic triggered a proliferation of emergent ethnomedical cultural responses. With the appearance of cases in Nigeria, information about these practices quickly spread through social media and other communication channels into neighboring Cameroon as people attempted to assuage their uncertainty and significant fear of the disease. We assess this process of information-sharing about ethnomedical practices like salt-water baths and drinking as an Ebola preventive in light of theories on the spread of rumors. Rumors are mechanisms groups use to help order their experience of reality during times of environmental uncertainty and growing confusion; however, rumors can also impact public attitudes and behaviors in ways that expose individuals to greater risk. Based on data collected from 90 interviews with participants in two cities in Cameroon, we demonstrate that information on the prophylactic use of salt-water baths and drinking spread quickly and widely. This case affirms that people do not remain passive during times of an environmental emergency and that work in environmental health must pay heed to processes of rumor formation, spread, and impact. Keywords: Ebola; social stress;rumor; epidemics; ethnomedicine
Septic shock syndrome associated with generalized vasculitis

Zespół wstrząsu toksycznego jest ciężką uogólnioną reakcją zapalną spowodowaną zakażeniem gronkowcowym lub paciorkowcowym, charakteryzującą się gwałtownym przebiegiem, wysoką gorączką, uogólnioną wysypką skórną oraz objawami niewydolności wielonarządowej prowadzącymi do wstrząsu. Rozpoznanie ustala się na podstawie obrazu klinicznego oraz wyodrębnienia patogenu z ognisk zapalnych lub krwi (tab. I, II). Leczenie obejmuje stosowanie antybiotyków, intensywne leczenie wspomagające oraz podawanie preparatów immunoglobulin. Chorzy z zespołem wstrząsu toksycznego wymagają leczenia w warunkach oddziału intensywnej terapii. W pracy przedstawiono obraz kliniczny (ryc. 1) i trudności diagnostyczno-terapeutyczne zespołu wstrząsu toksycznego na przykładzie przypadku klinicznego niespełna 3-letniego chłopca, u którego rozpoznano ten zespół. S u m m a r y
Quality of Life Regarding People with an Ostomy: Integrative Review about Related Factors

Objective: Analyze the studies which present aspects related to the quality of life of patients with an ostomy. Method: It is about an integrative review in databases of the literature held in the Latin American Literature and Caribbean health sciences, Medical Literature Analysis and Retrieval System Online, Nursing Database, PubMed Central, Cumulative Index to Nursing and Allied Health Literature, Web of Science and SciVerse Scopus. Controlled keywords of the Medical Subject Headings (MESH) were used: “Ostomy” and “Quality of life”. The additional factors were: scientific articles that measure the QOL of people with an ostomy and/or scientific articles that show at least one aspect which affects the QOL of those people. After the analysis, the final sample was composed of 41 articles that passed through statistical analysis to identify the factors that best associated and correlated to the life quality of patients with an ostomy. Results: International studies with the level of evidence VI were predominant. 40 factors associated with the QOL of people with an ostomy were observed and subdivided into the domains: sociodemographic, clinical, physical, psychological and social. Conclusion: The main factors related to the quality of life of patients with an ostomy were: age, income, gender, change in physical and in sexual function (p<0,001). However, as it is about a review study, it needs the validation of the factors that most stand out in this theme.
Homocysteine ,Folic acid ,Vitamin B 12 and Pyridoxine : Effects on Vaso-Occlusive Crisis in Sickle Cell Anemia and Sickle -Thalassemia

BACKGROUND: Hemoglubiopathies include sickle cell anemia and the Thalassemia . S/ β0- Thalassemia have a clinical course similar to HbSS. Elevated concentration of Homocysteine contribute to thrombosis , a frequent event in sickle cell anemia . Vitamin B12, Pyridoxine , and folic acid deficiencies lead to dangerous increase in plasma Homocysteine. OBJECTIVE: 1- To test whether children with sickle cell anemia and Sickle cell – Thalassemia have elevated concentration of serum Homocysteine with diminished level of folate, B6, B12. 2- To determine whether hyperomocysteinaemia has a correlation with the frequency of Vasoocclusive crisis. PATIENTS AND METHOD: A case- control study was carried over a period of one year from Jan.- Dec. 2010 inclusive, 30 patients were collected from the Thalassemia centre in Ibn –AL-Baldy Hospital together with healthy 30 cases, age and sex matched ,were taken from AL- Kadhimiyia Teaching Hospital. Venous blood sample were aspirated from both groups to estimate serum Homocysteine, Folic acid, B12 and B6 level. Statistical analysis was done, using the student T-test ( P. value 0.05. Significant inverse correlation was found between Homocysteine level and B6 level. A strong positive correlation between Homocysteine level and the frequency of Vaso-occlusive crisis was found. CONCLUSION: Patients with sickle cell disease have high serum level of Homocysteine with low level of folic acid and pyridoxine. This Hyperomocysteinaemia is significantly inversely correlated with pyridoxine deficiency , but positively correlated with the frequency of Vaso-occlusive crisis.
A Comparative Study Of The Prevalence Of Helicobacter Pylori Between The Inhabitants Of Areas Of Different Barometric Pressure

Background: There are significant geographical and social differences in the prevalence of Helicobacter pylori. Jordan Valley is located at 280-420 meters below, while Irbid city is at 600 meters above sea level. This study is designed to examine the prevalence of Helicobacter pylori infection in the below and above sea level environments. Patients and Methods: A prospective comparative analysis of the prevalence of Helicobacter pylori in gastric biopsy specimens between patients living in Irbid city (group 1) and those living in the Jordan Valley (group 2) was performed. Another group of patients, originally from the Jordan Valley, who are currently residing in Irbid city for at least the last 10 years (group 3) was examined similarly to investigate the possible role of the genetic factor. Results: The 3 groups were comparable in age, gender distribution, and duration of symptoms. The prevalence of Helicobacter pylori infection in group 1 was 82% (143/171). On the other hand, the prevalence of this infection in group 2 was 70% (66/96), which is significantly lower than that of group 1. The prevalence of this infection in group 3 was significantly indifferent from that of patients from Irbid city (80% (32/40)). Conclusions: It is perhaps the environmental factors including the barometric pressure and seasonal temperature rather than the genetic background that is responsible for the difference of Helicobacter pylori infection between patients of the Jordan Valley and those of Irbid city.
Nursing Documentation in a Mature EHR System

aBstract Computerized patient care documentation (CPD) is a vital part of a Patient Care Information System (PCIS). Studying CPD in a well-established PCIS is useful because problems of system adoption and startup do not interfere with observations. Factors interfering with optimal nursing use of CPD are particularly challenging and of great concern, given today's shortage of nursing manpower. We describe BLOCKINproblems BLOCKINand BLOCKINadvantages BLOCKINof BLOCKINCPD BLOCKINusage BLOCKINidentified BLOCKINby BLOCKINnurses BLOCKINin BLOCKINa BLOCKINseries BLOCKINof BLOCKINresearch BLOCKINinterviews. The chief advantages of CPD for nurses found were better accessibility and reliability of patient care documentation. BLOCKINof BLOCKINconsider-ing mobile and team-oriented technologies in future versions of the PCIS.
Using AI-Based Classification Techniques to Process EEG Data Collected during the Visual Short-Term Memory Assessment

Visual short-term memory (VSTM) is defined as the ability to remember a small amount of visual information, such as colors and shapes, during a short period of time. VSTM is a part of short-term memory, which can hold information up to 30 seconds. In this paper, we present the results of research where we classified the data gathered by using an electroencephalogram (EEG) during a VSTM experiment. The experiment was performed with 12 participants that were required to remember as many details as possible from the two images, displayed for 1 minute. The first assessment was done in an isolated environment, while the second assessment was done in front of the other participants, in order to increase the stress of the examinee. The classification of the EEG data was done by using four algorithms: Naive Bayes, support vector, KNN, and random forest. The results obtained show that AI-based classification could be successfully used in the proposed way, since we were able to correctly classify the order of the images presented 90.12% of the time and type of the displayed image 90.51% of the time.