Miracle-dz/UniFAR-FTUs huggingface dataset:
Anti-thrombotic effect of Zingiber officinale (ginger) in sprague dawley rats

Background: The prevalence of thrombotic diseases is rising globally. Presently, stroke and ischemic heart disease account for 25% of all deaths. Use of anti-thrombotic drugs have proven effective in prevention of these ailments but might not be affordable especially in developing countries. They are also associated with undesirable side effects. This study sought to determine the anti-thrombotic effect of ginger since it is affordable, accessible and is widely used as a food enhancer and a medicinal herb.Methods: The current study employed an in-vivo experimental study design. Three groups Sprague dawley rats (N=5) were given different doses of methanolic extract of ginger for 30 days. Two other groups (N=5) which served as controls received 5% dimethyl sulfoxide and aspirin for the same duration. Measurement of bleeding time, platelet count, prothrombin time, activated partial thromboplastin time and thrombin time was done to assess the anti-thrombotic property.Results: There was a statistically significant difference in bleeding time (P=0.03) across the groups investigated. There was however no significant difference across the groups in platelet count, prothrombin time, activated partial thromboplastin time and thrombin time (P=˃0.05). Conclusion: This study demonstrates that methanolic extract of ginger possesses an anti-thrombotic property probably through inhibition of platelet function. Regular consumption of ginger may therefore confer protection against thrombotic diseases.
Voriconazole (Vfend): une nouvelle arme contre les mycoses invasives.

Voriconazole is a fluoropyrimidine derivative of fluconazole with an extended spectrum of activity, non-linear pharmacokinetic characteristics, available intravenously and orally with an excellent bioavailability, and a good penetration into tissues including the brain. It is metabolized in the liver by the cytochrome P450 and less than 1% is eliminated in the urine. Voriconazole has been studied extensively in numerous randomized clinical trials of invasive fungal infections and became the therapy of choice of invasive aspergillosis, fusariosis and scedosporiosis. Voriconazole is an alternative for invasive candidiasis refractory or resistant to fluconazole. Voriconazole has a good tolerability and acceptable safety profile and has added a new weapon to our therapeutic armamentarium against fungi.
Models Of Family Therapy: The Essential Guide

Family Therapy Models: Structure and Rationale. Structural Family Therapy. Strategic Family Therapy. Behavioral Family Therapy. Psychoeducational Family Therapy. Communication Models: Mental Research Institute. Milan Family Therapy (Systemic). Narrative Family Therapy. Solution-Focused Therapy. Object Relations Theory. Bowens Systems Therapy. Experiential Family Therapy. Ethics. Gender and Ethnicity. Model Comparisons. Questions. References.
On the Cellular Basis of Aerobic Fitness : Intensity-Dependence and Time-Course of Cardiomyocyte and Endothelial Adaptations to Exercise Training

Beneficial effects of exercise are closely associated with fitness and maximal oxygen uptake (VO2max). Capacity for oxygen transport increases mainly by improved cardiac function, including larger chamber volumes, myocardial hypertrophy, and enhanced diastolic and systolic function. Higher arterial conductance, capillarity, and oxygen utilization in skeletal muscle also contribute. The present thesis investigates the cellular basis for cardiac and arterial effects; how they correlate with changes in VO2max during exercise training at high or moderate intensity, and during detraining.The studies show that:1. Regular aerobic exercise training increases running performance and VO2max, induces cardiac hypertrophy, and improves cardiomyocyte contractility and arterial endothelial function.2. High intensity exercise is more effective than moderate intensity exercise to increase aerobic fitness.3. VO2max correlates closely with cardiomyocytes size, contractility, and calcium handling during adaptation in the first weeks of exercise, during detraining, and with different training intensities.We conclude that:1. Aerobic fitness is intimately related to cardiomyocyte size and function.2. The magnitude of adaptation to training depends on exercise intensity.3. Intensity emerges as an important determinant for beneficial effects of exercise training.
DEVELOPMENT AND COMPARISON OF RISK-ADJUSTED MODELS TO BENCHMARK ANTIBIOTIC USE IN THE UNIVERSITY HEALTHSYSTEM CONSORTIUM HOSPITALS

DEVELOPMENT AND COMPARISON OF RISK-ADJUSTED MODELS TO BENCHMARK ANTIBIOTIC USE IN THE UNIVERSITY HEALTH SYSTEM CONSORTIUM HOSPITALS By Omar M. Ibrahim, BS.C. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2012 Major Director: Ronald E. Polk, Pharm.D. Professor, Department of Pharmacotherapy and Outcomes Science Background. Infectious diseases societies recommend that hospitals riskadjust their antimicrobial use before comparing it to their peers, a process called benchmarking. The purpose of this investigation is to apply and compare 3 risk-adjustment procedures for benchmarking hospital antibacterial consumption (AbC). Two standardization of rates procedures, direct and indirect standardization, are compared with one another as well as with regression modeling. Methods. Total aggregate adult AbC for 52 systemic antibacterial agents was measured in 70 hospitals that subscribed to the University HealthSystem Consortium Clinical Resource Manager database in 2009 and expressed as days of therapy (DOTs) per either 1000 patients days (PDs) or 1000 discharges. The two AbC rates served the role of the outcome while several known risk factors for AbC served the role of potential predictor variables in the linear regression models. Selection criteria were applied to select a model that represented the first rate (Model I) and another that represented the second (Model II), respectively, and outliers were identified. Adult discharges in each hospital were then stratified into 35 clinical service lines based upon their Medicare Severity-Diagnosis Related Group (MSDRG) assignment. Direct and indirect standardization were applied to this set and the expected-to-observed (E/O) and observed-to-expected (O/E) ratios, respectively, for AbC were determined. The agreement of the different methods in ranking hospitals according to their risk-adjusted rates and in identifying outliers was determined. Results. The mean total AbC rate was 821.2 DOTs/1000 PDs or 4487.6 DOTs/1000 discharges. Model I explained 31% of the variability in AbC measured in DOTs/1000 PDs while Model II explained 64% of the variability in AbC measured in DOTs/1000 discharges. The E/O ratios ranged from 0.76-1.44 while the O/E ratios ranged from 0.73-1.45. The comparison of the risk-adjustment methods revealed a very good agreement between the two regression models as well as between the two standardization methods whereas the agreement of Model II with either standardization method was
A Review of Alternative Evaluation Studies

—Different from traditional standardized test, alternative evaluation is a new learner-centered educational evaluation form. It can improve learners' ability of self-management, self-reflection and self-learning. In order to promote the diversified development of Japanese teaching evaluation mode, this paper investigates the emergence and development of alternative evaluation and its research and application in Japanese teaching at home and abroad, and analyzes its characteristics and applicability.
FACTORS AFFECTING PROFITABILITY OF INSURANCE COMPANIES IN ETHIOPIA

v CHAPTER ONE: INTRODUCTION . 1 1.1 Background of the study . 1 1.2 Overview of Insurance Industry in Ethiopia . 4 1.3 Statement of the problem . 5 1.4 Basic Research Questions . 8 1.5 Objectives of the study . 9 1.6 Hypothesis . 9 1.7 Definition of Terms . 11 1.8 The significance of the study . 13 1.9 Scope and limitation of the study . 14 CHAPTER TWO: REVIEW OF RELATED LITERATURE . 16 2.1 Theoretical review . 16 2.1.1 Definition of insurance and the concept of insurance companies and their profitability . 16 2.1.2 Concept of insurance companies and their profitability . 18 2.2 Factors affecting the profitability of insurance companies: An Empirical Review . 21 2.3 Summary of the literature review & Conceptual Framework . 34 2.3.1 Summary of the literature review . 34 2.4 Conceptual Framework . 35 CHAPTER THREE: RESEARCH DESIGN AND METHODOLOGY . 37 3.1 Research Design . 37 3.1.1 Research methods adopted . 37 3.1.2 Quantitative aspect . 38 3.1.2.1 Survey design: documentary Analysis . 38 3.1.3 Qualitative aspect . 38 3.2 Study population and sampling technique . 39 3.3 Types of data and instrument of data collection . 40 3.4 Method of data analysis. 40 3.4.1 Variable specification . 44 3.4.1.1 Dependent variable . 44 3.4.1.2 Independent variables . 44 CHAPTER FOUR: RESULTS AND DISCUSSION . 48 4.1 Result of the Study . 48 4.1.1 Model Specification Test (Fixed effect Versus Random effect) . 48 4.1.2 Result descriptive statistics . 52 4.1.3 Result of correlation Analysis . 55 4.2 Result on Regression analysis . 57 4.3 Discussion of the study . 60 CHAPTER FIVE: CONCULUSION AND RECOMANDATION . 65 5.1 conclusions . 65 5.2 Recommendations . 66 References . Appendices .
Semi-Supervised Manifold Alignment Using Parallel Deep Autoencoders

The aim of manifold learning is to extract low-dimensional manifolds from high-dimensional data. Manifold alignment is a variant of manifold learning that uses two or more datasets that are assumed to represent different high-dimensional representations of the same underlying manifold. Manifold alignment can be successful in detecting latent manifolds in cases where one version of the data alone is not sufficient to extract and establish a stable low-dimensional representation. The present study proposes a parallel deep autoencoder neural network architecture for manifold alignment and conducts a series of experiments using a protein-folding benchmark dataset and a suite of new datasets generated by simulating double-pendulum dynamics with underlying manifolds of dimensions 2, 3 and 4. The dimensionality and topological complexity of these latent manifolds are above those occurring in most previous studies. Our experimental results demonstrate that the parallel deep autoencoder performs in most cases better than the tested traditional methods of semi-supervised manifold alignment. We also show that the parallel deep autoencoder can process datasets of different input domains by aligning the manifolds extracted from kinematics parameters with those obtained from corresponding image data.
Effect of different Waste Materials Addition on the Properties of Clay Bricks

: The disposal of wastes becomes major problems in the world and effects to environment and becoming toxic. Fly ash is one of the many substances that causes air, water and soil pollution. Along with this some other materials like saw dust, rice husk, bagasse also effects the environment pollution and some disturbances to the human activities. In order to save the precious land and soil from being used in manufacturing building bricks and to save the environment from the waste. In this project, the experiment will be done to know whether these materials addition alters the properties of bricks or not. Based on experimental results such as compressive strength, impact strength, efflorescence test, firing shrinkage, apparent porosity, bulk density, water absorption of different batches were calculated. it was concluded that the bricks with the waste material admixture, gave the good quality.
Managing Blood Glucose with Local Nutrition Bars: A Collaborative Exploration

As a health conscious and busy college student, I always look for nutritious and convenient snacks. However, when I peruse the energy bar section of the grocery store, I usually find myself disappointed. So many packages grab my attention with health and nutrition claims yet so few hold any appeal after I read the ingredient labels. Most bars use added fiber, protein, or multivitamin powder as a substitute for higher quality whole grains, fruits, nuts and seeds. Fortunately, through my work in a University of New Hampshire nutrition lab, I recently discovered a health bar to end my search. Omega Smart is a small New Hampshire company that produces organic, whole food bars designed to address a variety of health concerns. These fruit-based bars are rich in antioxidants, omega–3 fatty acids and fiber, and contain no refined sugar, preservatives, artificial colors, flavorings, or other additives. For me, that is a recipe for success.
Formation of gas hydroxide of sulfur dioxide at liquid sulfur dioxide injection in a porous medium saturated with methane and water

A mathematical model of injection of liquid sulfur dioxide into a porous medium saturated with water and methane, accompanied by the formation of SO2 gas hydrate on the frontal surface is presented. The dependences of the temperature and the coordinates for the formation front of sulfur dioxide gas hydrate on the pressure of the injection and the initial pressure of the layer are explored. It is established that at sufficiently high injection pressure values and the initial temperature of the layer, as well as the low values of the layer’s initial pressure, the temperature of the porous medium on the boundary of gas hydrate formation of sulfur dioxide may rise above the decomposition’s equilibrium temperature of the gas hydrate of sulfur dioxide. This corresponds to the appearance of a zone in a porous medium saturated with a mixture of water, sulfur dioxide and its gas hydrate, being in a state of phase equilibrium.A mathematical model of injection of liquid sulfur dioxide into a porous medium saturated with water and methane, accompanied by the formation of SO2 gas hydrate on the frontal surface is presented. The dependences of the temperature and the coordinates for the formation front of sulfur dioxide gas hydrate on the pressure of the injection and the initial pressure of the layer are explored. It is established that at sufficiently high injection pressure values and the initial temperature of the layer, as well as the low values of the layer’s initial pressure, the temperature of the porous medium on the boundary of gas hydrate formation of sulfur dioxide may rise above the decomposition’s equilibrium temperature of the gas hydrate of sulfur dioxide. This corresponds to the appearance of a zone in a porous medium saturated with a mixture of water, sulfur dioxide and its gas hydrate, being in a state of phase equilibrium.
Standardization of a protocol to irradiate cell cultures with low level laser

Introducción: No es posible aplicar láser terapéutico durante los tratamientos de Ortodoncia y seleccionar diferentes tiempos, frecuencia o intensidad para cada célula. Se irradia toda el área de interés con las mismas características en segundos, julios y vatios. Esto podría tener un potencial proliferativo en algunas células y nocivo en otras. Es importante entonces, evaluar los efectos de una misma dosis de irradiación en todas células que participan durante el movimiento dental para conocer su reacción individual ante el láser terapéutico de uso clínico. Objetivo: Estandarizar un protocolo para irradiar cultivos celulares de las células implicadas en el movimiento dental inducido (Fibroblastos, Osteoblastos y PreOsteoclastos humanos) para entender la fundamentación básica de su efecto clínico. Materiales y métodos: Con un laser de AsGa-Al se irradiaron Fibroblastos gingivales y periodontales, Osteoblastos humanos normales (NHOst) y células progenitoras de osteoclastos humanos. Se empleó una longitud de Onda de 832.79nm, 36.73mW de potencia, 3.75 J/cm2 y 32,40 segundos por pozo. Conclusiones: Las pruebas de citotoxicidad demostraron que este protocolo de irradiación es seguro para los cuatro grupos de cultivos celulares.
Hearing Mechanisms in Vertebrates. A Ciba Foundation Symposium

available and educating the medical and veterinary professions to avoid their indiscriminate use, the need for newer antibiotics would be greatly reduced. This publication although it can hardly be termed a book of reference does meet a need in this particular field and the Editorial Board are to be congratulated on its mode of presentation. All the papers are accompanied by an adequate bibliography.
Nutrition and Healthy Aging in the Community: Workshop Summary

The U.S. population of older adults is predicted to grow rapidly as "baby boomers" (those born between 1946 and 1964) begin to reach 65 years of age. Simultaneously, advancements in medical care and improved awareness of healthy lifestyles have led to longer life expectancies. The Census Bureau projects that the population of Americans 65 years of age and older will rise from approximately 40 million in 2010 to 55 million in 2020, a 36 percent increase. Furthermore, older adults are choosing to live independently in the community setting rather than residing in an institutional environment. Furthermore, the types of services needed by this population are shifting due to changes in their health issues. Older adults have historically been viewed as underweight and frail; however, over the past decade there has been an increase in the number of obese older persons. Obesity in older adults is not only associated with medical comorbidities such as diabetes; it is also a major risk factor for functional decline and homebound status. The baby boomers have a greater prevalence of obesity than any of their historic counterparts, and projections forecast an aging population with even greater chronic disease burden and disability. In light of the increasing numbers of older adults choosing to live independently rather than in nursing homes, and the important role nutrition can play in healthy aging, the Institute of Medicine (IOM) convened a public workshop to illuminate issues related to community-based delivery of nutrition services for older adults and to identify nutrition interventions and model programs. Nutrition and Healthy Aging in the Community summarizes the presentations and discussions prepared from the workshop transcript and slides. This report examines nutrition-related issues of concern experienced by older adults in the community including nutrition screening, food insecurity, sarcopenic obesity, dietary patterns for older adults, and economic issues. This report explores transitional care as individuals move from acute, subacute, or chronic care settings to the community, and provides models of transitional care in the community. This report also provides examples of successful intervention models in the community setting, and covers the discussion of research gaps in knowledge about nutrition interventions and services for older adults in the community.
Design of Caffeine-Loaded Nanostructured Lipid Carriers Containing Coconut Oil for Topical Application

Although caffeine was suggested as one of the pharmacological agents for the cellulite treatment, its skin permeation restricted. The present work was aimed at formulating caffeine loaded nanostructured lipid carriers (CAF-NLCs) containing coconut oil as a topical delivery system. CAF-NLCs were prepared by the ultrasonic emulsification method, using coconut oil as a liquid lipid. The proper selection of solid lipid and surfactants for these formulations were investigated. Subsequently, physicochemical properties, entrapment efficacy, stability, and in vitro drug release were evaluated. The CAF-NLCs containing coconut oil was successfully prepared using glyceryl behenate as a solid lipid and showed an interesting entrapment efficiency (62-99%). The obtained CAF-NLCs presented the nanosized range (≈ 60-390 nm), with a low polydispersity index and high negative zeta potential values (over ‐30 mV). However, the type and concentration of surfactant also affected these properties. These results suggested that CAF-NLCs containing coconut oil are the promising carrier for delivery of caffeine following topical application.
Does Aliskiren Influence the Changes of Global Longitudinal Strain in Patients with Diastolic Dysfunction

Маterial and Methods: Forty five nondiabetic patients (29 men and 16 women, mean age 58.7±12.4) with blood pressure (BP) > 140 / 90 mm Hg despite of combined antihypertensive therapy (diuretic, calcium channel blockers, betablockers) were evaluated. All of them had echocardiographic (echoCG) data for DD І st degree: Е/Е`ratio ≤ 8, Е/А ratio 200 msec. Aliskiren 150 mg BID was added to the previous therapy. BP changes evaluation, echoCG assessment of GLS and Doppler analysis of the transmitral blood flow were performed at months: 1, 6 and 12.
Measuring the Physical Activity of Children aged 3 to 7 years

i LIST OF FIGURES vii LIST OF TABLES viii LIST OF ABBREVIATIONS ix CHAPTER 1: INTRODUCTION 1 1.1 Problem Statement 1 1.2 Study Aims 2 1.3 Research Strategy 3 CHAPTER 2.1: A GLOBAL EPIDEMIC – OVERWEIGHT/OBESITY 4 2.1.
Practical aspects of heat conduction simulation in household heating optimization tasks

Mathematical model selection for simulation heat conduction processes in household heating optimization task is considered. The essence of the matter is that the heat transfer dynamics properties are very diversified, so simulation procedure formulae and parameters should be properly selected to avoid excessive modeling errors with reasonable calculation time being held. The typical state-space model and analytical formulae for step response of the heat conduction across a homogeneous wall are presented and compared in terms of modeling errors. Formal and numerical problems of heat losses simulation are discussed. Semi-analytical step-response formulae for multilayer walls are derived and their accuracy is compared with effects of simulation based on the state-space model. Some recommendations for time and space discetization parameters are given.
Neuromuscular electrical stimulation in dyspneic COPD patients: a new training modality

• A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.