Miracle-dz/UniFAR-FTUs huggingface dataset:
Oceanic Impacts on MJOs Detouring near the Maritime Continent

Madden–Julian oscillations (MJOs) are the dominant mode of intraseasonal variability (ISV) in the atmosphere acting as a bridge between weather and climate. During boreal winter, many MJO events are detoured southward while propagating across the Maritime Continent. Although MJO simulations have been greatly improved in recent years, the mechanism and simulation of MJO detouring near the Maritime Continent are still a great scientific challenge. Several mechanisms have been proposed based on atmospheric dynamics and thermodynamics. In this study, the oceanic role in MJO detouring is diagnosed using observations and reanalysis products. It is found that warm sea surface temperature (SST) anomalies occur over the southeastern Indian Ocean that induce a cyclone in the lower troposphere. Due to the westerly background winds, westerly winds are strengthened (weakened) to the north (south) of warm SST anomalies. As a result, the latent heat flux (LHF) is enhanced, and convection is reinforced to the north of warm SST anomalies. In contrast, the LHF is reduced, and SSTs warm to the south of pre-existing warm SST anomalies. Hence, the warm SST anomalies and convection system shift the MJOs southward before they reach the Maritime Continent. The identification of the oceanic influence on the MJO detouring deepens our understanding of the mechanism of their detour and elicits the role of the ocean. It is expected to brighten the prospects for better simulation and forecast of MJOs over the Maritime Continent. The oceanic ISV in the southeastern Indian Ocean is subject to many forcings, such as intraseasonal atmospheric forcing, the Indonesian Throughflow, local oceanic instability, and coastal Kelvin waves along Sumatra. Determining the mechanism of ISV in the southeastern Indian Ocean requires further dedicated studies.
Utilization of Molecular Marker to Improve Cattle Carcass Quality in Indonesia

Cattle is one of the commodities that have a national priority to achieve self-sufficiency in animal protein food for the Indonesian people. Beside beef sufficiency, demand on good quality meat in Indonesia is also increasing. Good quality carcass with lower fat content can give higher economic value. The purpose of this paper is to discuss the use of molecular markers to improve the quality of beef cattle carcass. Heritability value in carcass characteristic is low to moderate value, but it can be increased by selection using certain molecular markers. Several genes have been identified and correlated with carcass quality in several breed of cattle. Study in Bali cattle showed that the Calpain (CAPN1) and Calpastatin (CASTN) genes could be used as molecular markers to select Bali cattle with higher quality carcass because these genes were associated with carcass quality traits. In conclusion that Calpain (CAPN1) and Calpastatin (CASTN) genes can be used for local beef cattle selection toward better carcass quality and have opportunity to be utilized to improve carcass quality of other beef cattle breeds in Indonesia.
Antihypertensive treatment in critical limb Ischaemia

Peripheral artery disease (PAD) is defined as atherosclerotic arterial occlusive disease of the lower extremities, manifesting as intermittent claudication (IC, pain induced by walking) or critical limb ischaemia (CLI, rest pain or ulcerations). PAD guidelines recommend strict control of cardiovascular risk factors, and European guidelines on hypertension recommend a blood pressure (BP) target < 140/90 mm Hg also in PAD patients. As the pressure in the affected extremity might be of relevance for the prognosis concerning limb salvage in CLI, the traditional approach was to avoid beta-blockers and allow a slightly higher BP in CLI. Both theoretical considerations and observational data support aggressive BP lowering also in CLI; however, in the absence of randomized studies on BP lowering in this setting it cannot be definitely established that current recommendations on BP lowering apply also in CLI.
Orchestrating the Digital Transformation Process through a 'Strategy-as-Practice' Lens: A Revelatory Case Study

Implementing a digital transformation (DT) strategy constitutes an important challenge for most firms. Small and medium-sized enterprises (SMEs) in particular must be helped in enacting and managing their DT process. To do so, we aim to answer two research questions: What are the dimensions that define a DT strategy in a SME context? And how do these dimensions contribute to the enactment of a DT process in this context? Using an information systems (IS) strategy-as-practice theoretical lens, combined with an information technology (IT) asset orchestration perspective, we opt for an interpretive case study of an industrial service SME whose characteristics are conducive to a renewed vision of IS strategy in a DT context. From this study emerges a process model that allows us to describe and better understand, in a concrete manner, how a DT occurs and how it is managed through a coherent DT strategy.
Query-By-Committee Framework Used for Semi-Automatic Sleep Stages Classification

Active learning is very useful for classification problems where it is hard or time-consuming to acquire classes of data in order to create a subset for training a classifier. The classification of over-night polysomnography records to sleep stages is an example of such application because an expert has to annotate a large number of segments of a record. Active learning methods enable us to iteratively select only the most informative instances for the manual classification so the total expert’s effort is reduced. However, the process is able to be insufficiently initialised because of a large dimensionality of polysomnography (PSG) data, so the fast convergence of active learning is at risk. In order to prevent this threat, we have proposed a variant of the query-by-committee active learning scenario which take into account all features of data so it is not necessary to reduce a feature space, but the process is quickly initialised. The proposed method is compared to random sampling and margin uncertainty sampling which is another well-known active learning method. It was shown that, during crucial first iteration of the process, the provided variant of query-by-committee acquired the best results among other strategies in most cases.
Detección y diagnóstico de fallas en sistemas eléctricos de potencia combinando una red neuronal autoasociativa y una red neuronal probabilística

Resumen. El monitoreo de los sistemas de potencia es particularmente retador debido a la presencia de cambios din´amicos de carga en modo de operaci´on normal en los nodos de la red, presencia de variables conti-nuas y discretas, informaci´on con presencia de ruido y falta o exceso de datos. Por ello, la necesidad de desarrollar metodolog´ıas m´as poderosas que combinen t´ecnicas de inteligencia artiﬁcial ha sido reconocida. Este art´ıculo propone un sistema de monitoreo basado en los datos hist´oricos del sistema compuesto por dos fases. En la primera fase aprende el comportamiento de la operaci´on normal del sistema utilizando una red neuronal autoasociativa (RNAA), la cual lleva a cabo el proceso de detecci´on. En la segunda fase se da el diagn´ostico ﬁnal empleando una red neuronal probabil´ıstica (RNP), la cual clasiﬁca el tipo de falla presente y proporciona su tiempo de ocurrencia.
Cystic fibrosis (CF) in adult patients: correlation of lung function test results and pathologic lung morphology as expressed by the Brody score

Poster: "ECR 2012 / C-0808 / Cystic fibrosis (CF) in adult patients: correlation of lung function test results and pathologic lung morphology as expressed by the Brody score" by: "U. Mueller-Lisse, M. Schmitz, N. Ashoori, S. Allert, I. Mindiuk, J. Pichler, R. Fischer, R. Huber, M. F. Reiser; Munich/DE"
Phase II study of combination of the hyperCVAD regimen with dasatinib in patients (pts) with newly diagnosed Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL)

7020 Background: Combination of cytotoxic chemotherapy with imatinib has improved the outcome for pts with Ph+ ALL. Dasatinib is a significantly more potent BCR-ABL inhibitor and is effective in pts with Ph+ ALL. Methods: Pts with newly diagnosed Ph+ ALL were treated with dasatinib 50 mg po bid for the first 14 days of each of 8 cycles of alternating hyperCVAD and high dose cytarabine and methotrexate. Pts in CR continue to receive maintenance dasatinib 50 mg po twice daily indefinitely, and vincristine and prednisone monthly for 2 yrs. Results: To date, 20 pts have received a median of 5 cycles (range, 1–8); 8 pts are receiving maintenance in CR. Median age is 55 yrs (range, 23 - 79); 16 pts were > 50 yrs. Median WBC at diagnosis was 4.7 x 109/L (range, 0.8 - 203.4 x 109/L). Four pts had CNS involvement at diagnosis. Nineteen pts are evaluable for response assessment; one pt is too early. Seventeen pts (90%) have achieved CR after the first cycle; 2 pts died before response assessment from infections. Fo.
Mir-217 Reverses the TKI Drug-Resistance of K562 Cells By the Downregulation of Heme Oxygenase-1

Upregulation of Heme oxygenase-1 (HO-1) strengthens drug-resistance to apoptotic death in the several kinds of cancer cells. Our recent study shows the higher levels of HO-1 expression in the thyrosine kinase inhibitors (TKI) resistance K562 cell line and cells from Imatinb-insensitive CML patients. The cause of HO-1 upregulating, though, is still unclear yet. MicroRNAs (miRNAs) play a significant role in the pathogenesis of cancer. They also are known as potential biomarkers and therapeutic targets. In the hematological neoplasm, miRNAs take part in not only cancer development, but also drug resistance. However, the problem has not been solved yet is how the microRNA involved in. This study found that the expression level of microRNAs were much different depended on if it is Imatinb-insensitive or not. The phenomenon was observed both in the K562 and CML patients. The mir217 was one of these microRNAs that significantly deceased when the K562 had been induced to resist the Imatinb. Meanwhile,TKI-resistance K562 cells can be in association with an increase in levels of HO-1 and a decrease in levels of miR-217. In the TKI-resistant K562 cells, the decreased of miR-217 upregulated the expression of HO-1 through a 39-untranslated region(UTR) of HO-1 and induced the resistance against TKI. Interestingly, TKI-resistant K562 cells exposed to miR-217 mimic can partially make the cells be sensitized to TKI again in association with upregulation of miR-217 and downregulation of HO-1 in vitro. The IC50 of the TKI-resistant K562 cells exposed in 7.5uM Imatinb for 48 hours also decreased after transfecting miR-217 mimic for 48 hours. In our on-going experiment, the express level and interaction of HO-1 and miR-217 will be tested in K562 tumors growing in immune-deficient mice that were treated with the combination of mir-217 inhibitor, expression HO-1 virus and TKI. The express of HO-1 and miR-217 also will be examined in the TKI-insensitive CML patients and the mir217 and HO-1 regulated mechanism will be investigated in vivo. According to our results, the reversibility of the mir-217 downregulating Heme oxygenase-1 in the K562 cells with TKI drug tolerance likely provides a potentially exciting miRNA therapeutic strategy. MiRNAs therapy could be utilized as a powerful therapy which would focus to the drug-resistance patients. Drug-resistance cancer cells may be sensitized to former conventional or targeted chemotherapy. Disclosures No relevant conflicts of interest to declare.
Facijalna morfologija kod različitih ortodontskih anomalija

People have been studying facial aesthetics since ages. Orthodontics as a specialist branch was defined in the end of the 19th century when Angle defined three types of malocclusion. Nowadays orthodontic therapy is needed when dealing with unsatisfactory facial aesthetics. The aim of therapy is not only to achieve ideal occlusion but also to make soft facial tissue look harmonious. It is of great importance to analyze soft facial tissue separate from dentoskeletal analysis when planning therapy. Frontal facial analysis and profile analysis are both done. Frontal plane facial analysis consists of a vertical component and a horizontal component. When analyzing face profile linear and angular measurements such as S- line, H- line, E- line, B-line, and nasolabial and mentolabial angles are used. The term malocclusion refers to a situation when teeth or two dental arches are not positioned properly. The causes of malocclusion are of specific nature; they are hereditary and occur due to the influence of the environment. Various orthodontic anomalies occur when these factors interact. These anomalies have a specific look. Third class anomalies are real progenia and pseudoprogenia. Patients with real progenia have a concave profile and the lower third of the face is elongated. The chin is prominent and the lower lip is thickened and in front of the upper one. Patients with pseudoprogenia have a concave profile. Their maxilla is not well developed and the mandible is normal. Second class anomalies are divided into types II/1 and II/2. Patients with type II/1 anomaly have a convex facial profile, a prominent upper lip and a recessed chin whereas patients with type II/2 have a convex facial profile, contracted lower and enlarged middle part of the face as well as a prominent nose and a beard. An open bite is a vertical plane anomaly characterized by an elongated lower third of the face and lip incompetence.
Knowledge, attitude and practice study regarding pharmacovigilance programme of India among private practitioners in urban Odisha, India -

Background: Private health care providers play an important role in health programmes of a country. Pharmacovigilance programme of India (PVPI) seeks involvement of different health sectors to make it successful. Knowledge, attitude and practice (KAP) studies provide a base line information about human behaviour and practices so that a properly planned acceptable intervention can be made. Methods: level of knowledge, attitude and practice regarding pharmacovigilance programme of India was evaluated among doctors working in private hospitals/clinics of Bhubaneswar and Cuttack city of Odisha. A thirty three item questionnaire was used to collect the data which contained 12 knowledge, 12 attitude and 9 practice based questions. Results: Only fifty four out of 124 participating doctors responded positively. The knowledge level of practitioners was found to be acceptable with 38.9% subjects scoring more than 70%. However a gap in knowledge was observed regarding some specific area and was not translated in terms of good quality reporting of ADRs. Only 13 (24.1%) practitioners were found to have actually reported ADR to Pharmacovigilance centre. Conclusions: Adequate awareness should be created among private practioners regarding the pharmacovigilance programme of India. Easy accessibility of ADR forms and appropriate educational intervention through media can improve ADR reporting.
Microhistological Analysis of Cows' Diet during a Severe Drought in the Semi Arid Region of North Patagonia (Argentina)

The continuous use of the livestock fields of the Middle Valley of Río Negro, North Patagonia, Argentina, combined with adverse weather conditions that occur periodically, have contributed to the degradation of rangelands. The historical annual average rainfall regime in the Valle Medio of Río Negro is 303 mm but between 2002 and 2011, the average deficit was 33%. According to the Rural Society of Choele Choel, due to the decreased forage on offer, the existence of cattle in 2011 dropped to 85,000 animals, representing 50% of the normal amount for the area. During these critical times of drought, when grasslands decrease in quantity and quality, shrubs are supposed to contribute to the diet of cattle in this area. Knowledge of the diet of grazing animals is important in developing management standards that allow the proper use of natural grasslands. The utilization of epidermal characteristics to identify plant components in esophageal, ruminal, or fecal samples is a widespread technique used to study diet composition of free-ranging herbivores (Holechek et al. 1982, Bóo et al. 1993, Lindström et al. 1998). Our study was designed to evaluate cow's diet from spring (September 2011) to early summer (January 2012), a particularly difficult period for breeders, in a plot of a field in this area of north Patagonia, Argentina.
Does Land Use Age Influence Carbon Cycling in the Tibetan Plateau?

Although substantial information had been generated on the effects of land use change on soil organic carbon (SOC) and total nitrogen (TN) storage, studies are absent on multifactorial effects of land use types, land use age, and elevation on SOC and TN storage. SOC and TN were therefore investigated in 30 field sites comprising natural forests, planted forests, shrub, and grasslands. SOC and TN stocks differed and correlated significantly with land use age; the C stocks correlates significantly with land use change compared the TN stocks. However, there was no relation between the C and N stocks with elevation, implying that SOC and TN are solely dependent on land use age. SOC sequestration potentials of the sampled ecosystems were 345.86, 293.19, 266.45, and 251.23 t ha−1 for the natural forests, planted forests, shrub, and grasslands with total mean value of 289.18 t·ha−1 (1,060.42 t·ha−1 CO2−eq). A significant SOC stock loss (17.96%, 29.80%, and 37.66%) occurred in converting natural forests to planted forests, shrub, and grasslands, whereas gains (27.36%, 14.31%, and 5.71%) would occur in reconverting grassland to natural forests, planted forests, and shrublands. Therefore, the C that was lost during deforestation and conversion of natural forests into other land use types could not match the carbon gains thereafter. Our results suggest that land use change and land use age have influenced soil C and N stocks. Moreover, natural forests are better in ecological conservation and restoration of degraded lands. This study provides baseline information for C and N management in ecologically restored and degraded lands.
Grit World Strategy to Evolve the Academic Grits of Senior High School Students

Problems emerged during the learning process are not frequently due to the cognitive disabilities of the students. Yet, it is more of a lack of grit. Low grit causes a person to not work hard, own no high standards, to not focusing on fulfilling their responsibilities, as well as to show no effort when facing failure, difficulties, and obstacles. The research method of this study is a quasi-experimental method. Acquisition of z count of 0.332 and known z table of 0.1255, then 3.27 <0.1255 means that H0 is rejected, which means that the grit world intervention is not effective in developing the academic grit of the experimental group and control group students. Identifying grits is one way to determine where students can put their efforts into learning to survive in facing academic challenges. Schools are not only focused on making student get high score, but how to teach to create solutions. Schools can teach grit and facilitate long-term goals and teach how to achieve them.
Investigation and Failure Mode of Asymmetric and Double Trench SiC mosfets Under Avalanche Conditions

In this article, commercially 1200-V asymmetric and double trench silicon carbide (SiC) metal–oxide–semiconductor-field-effect transistors (mosfets) from two manufacturers are investigated by experiment and finite-element simulation under single-pulse unclamped inductive switching (UIS) stress. The variation in avalanche time with mosfet avalanche energy and temperatures dependence of critical avalanche energy and maximum power dissipation are evaluated. It is found that two failure mechanisms are identified, i.e., thermal runaway and gate oxide rupture. For asymmetric trench SiC mosfets, the failure mode are all thermal runaway at various temperatures. However, the failure mode of double trench SiC mosfets is thermal runaway or gate oxide rupture, which indicates an instable avalanche robustness under UIS stress. The variations of dc parameters are recorded to evaluate external features of device failure. Furthermore, finite-element simulation is used to reveal the electro-thermal stress inside the device during avalanche. Finally, failed devices are decapsulated to verify the location of failure point from the perspective of the semiconductor die.
An Investigation of the Synchronization in Global House Prices

Purpose The purpose of this paper to provide a discussion of the empirical evidence and contributing factors of the synchronization of house prices globally. Design/methodology/approach The author reviewed the main studies on house price synchronization and conducted an empirical analysis using OECD house price indices. A discussion of the contributing factors of synchronization, with a focus on the demand and supply dimensions is provided, and synchronization across both countries and cities is examined. Findings Housing markets globally have become more synchronized; this is particularly clear for cities. The sustained demand for places that are attractive for financial motives and for lifestyle and sometimes climate along with the fact that such places tend to be supply-constrained is likely to lead to more synchronization across markets. Practical implications The conclusions are important for investors seeking to diversify their housing holdings internationally. The discussion should also benefit policy-makers. Originality/value To date, very scarce evidence exists on the synchronization of house prices globally. By surveying the results contained in previous studies and providing a thorough discussion of the possible drivers of house price synchronization, this study contributes to a better understanding of this important topic.
Post-seminal structure and development of the hemiparasitic plant Escobedia grandiflora (Orobanchaceae)

Escobedia grandiflora (L.f.) Kuntze is a wild hemiparasitic plant with orange roots. Little is known about the development of initial parasitism with the host, despite the significant value of roots for Central and South American communities. Therefore, this study aimed to characterize post-seminal structure and development of E. grandiflora in Pennisetum purpureum host. To analyze the structure and development of E. grandiflora, seedlings, stems and roots samples were processed and examined under light, confocal and scanning electron microscopy. Escobedia grandiflora seeds are composed of seed coat, perisperm, and embryo. Emergence of the radicle began eleven days after imbibition. Seedlings showed a root hair collar encircling the axis at the root-hypocotyl junction with elongation of internal cortical cells. Seedlings formed haustoria and successfully reached of the host roots 22 days following root emergence. In the root many starch grains were observed, albeit more scarce in the hypocotyl. After 43 days of root emergence, the seedling stage was finished with the formation of the definitive leaves, and star of the plant stage. After 64 days, root ramification, amount of starch, and orange pigmentation increased with formation of haustoria. The developmental pattern of E. grandiflora plants was slow, but the roots grew faster than the stem. Escobedia grandiflora seeds were not endospermic and have limited nutritional value. After root emergence, the young seedling must develop roots and starch storage towards to haustorium formation and attachment to host roots.