Miracle-dz/UniFAR-FTUs huggingface dataset:
Working memory impairment in a transgenic amyloid precursor protein TgCRND8 mouse model of Alzheimer's disease

The most profound deficits observed in Alzheimer's disease (AD) are in domains of episodic and working memory systems. Transgenic (Tg) mice expressing mutated human amyloid precursor protein (APP) genes offer a model to study the effect of AD pathology on cognition. We reported previously that APP TgCRND8 mice showed deficits in a reference and working memory evaluated in a Morris water‐maze test. In this study, we evaluated the working memory of TgCRND8 mice comparing two training paradigms in a six‐arm radial water maze. In the first paradigm, the exploration of the maze was constrained, forcing the mice to use a spatial mapping strategy. In the second paradigm, mice were unconstrained in their exploration of the maze. TgCRND8 mice proved to be significantly impaired in spatial working memory in both paradigms as compared with their non‐transgenic littermates. The analysis of data revealed that forcing mice to use a spatial strategy during training caused only a moderate improvement in the performance of all mice. However, unconstrained exploration of the maze not only resulted in a fast learning in control mice, but also facilitated the development of a chaining strategy in spatially impaired TgCRND8 mice. In conclusion, TgCRND8 mice showed impairment in spatial working memory but retained a plasticity to choose alternative search strategies.
Diffuse malignant epithelial mesotheliomas of the peritoneum in women

The behavior of diffuse peritoneal mesotheliomas in women and the possible relation between tumor morphology and outcome are uncertain. Reported survival has ranged from < 1 month to > 14 years, and a previous study found that tumor morphology could not be used reliably for predicting outcome. The authors examined the behavior of diffuse epithelial peritoneal mesotheliomas in women and the possible relation between pathologic features and outcome.
Correlation of iron exchange between the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one(L1) and transferrin and possible antianaemic effects of L1 in rheumatoid arthritis.

1 Smith M D, Ahern M J, Roberts-Thomson P J. Pulse methylprednisolone therapy in rheumatoid arthritis: Unproved therapy, unjustified therapy, or effective adjunctive treatment? Ann Rheum Dis 1990; 49: 265-7. 2 Wong C S, Champion G, Smith M D, et al. Does steroid pulsing influence the efficacy and toxicity of chrysotherapy? A double blind, placebo controlled study. Ann Rheum Dis 1990; 49: 370-2. 3 Vineyard G C, Fadem S Z, Dmochowski J, Carpenter C B, Wilson R E. Evaluation of corticosteroid therapy for acute renal allograft rejection. Surg Gynecol Obstet 1974; 138: 225-9. 4 Gardiner P V G, Griffiths I D. Sudden death after treatment with pulsed methylprednisolone. Br Med 1990; 300: 125. 5 Bocanegra T S, Castaneda M 0, Espinoza L R, Vasey F B, Germain B F. Sudden death after methylprednisolone pulse therapy. Ann Intem Med 1981; 95: 122. 6 Moses R E, McCormick A, Nickey W. Fatal arrhythmia after methylprednisolone therapy. Ann Intem Med 1981; 95: 781-2. 7 Garrett R, Paulus H. Complications of intravenous methylprednisolone pulse therapy. Arthritis Rheum 1980; 23: 677. 8 Liebling M R, Leib E, McLaughlin K, et al. Pulse methylprednisolone in rheumatoid arthritis. A double-blind cross-over trial. Ann Intern Med 1981; 94: 21-6. 9 Hansen T M, Dickmeiss E, Jans H, Hansen T I, Ingemann-Nielsen M, Lorenzen I B. Combination of methylprednisolone pulse therapy and remission inducing drugs in rheumatoid arthritis. Ann Rheum Dis 1987; 46: 290-5.
Analysis of Oxidative Phosphorylation of E.Coli in VHDL focused on gene sequence alteration

The present paper describes the oxidative phosphorylation of protein Ugd of E.Coli, linked with thyrosine phosphorylation of UDP gulucose dehydrogenase by Wzc and Etk. It is to be noted that during the process of dehydrogenases, the energy coupled with antiporters would facilitate the growth of etk knockout mutant gene in the specific pH range of E. coli environment. These mutant genes are responsible for resistance to polymyxin, which is an important consideration for the development of medicine for treatment of cancer. In this paper, gene analysis is done using VHDL with MODELSIM to illustrate the oxidative phosphorylation phase of Ugd gene. Simulink block diagram (.mdl file), derived from MATLAB simulation has been used to generate transfer function representing the oxidative phosphorylation in the E. coli environment with PKC. This transfer function has been programmed in VHDL. The input to VHDL is obtained from the output of the homeostat coupled with the transduction phase linked with PKC âÂÂ. From the output of the VHDL it is possible to monitor the sequencing of mutant gene related to pH responsible for resistance to antibody required for treatment of cancer.
A backward-compatible protocol for inter-routing over heterogeneous overlay networks

Overlay networks are logical networks running on the highest level of the OSI stack: they are applicative networks used by millions of users everyday. In many scenarios, it would be desirable for peers belonging to overlays running different protocols to communicate with each other and exchange certain information. However, due to differences in their respective protocols, this communication is often difficult or even impossible to be achieved efficiently, even if the overlays are sharing common objectives and functionalities. In this paper, we address this problem by presenting a new overlay protocol, called OGP (Overlay Gateway Protocol), allowing different existing networks to route messages between each other in a backward-compatible fashion, by making use of specialized peers joined together into a super-overlay. Experimental results on a large scale Grid5000 infrastructure show that having only a small number of nodes running the OGP protocol is sufficient for achieving efficient routing between heterogeneous overlay networks.
Calcium transport by sarcoplasmic reticulum of vascular smooth muscle: I. MgATP‐dependent and MgATP‐independent calcium uptake

The components of 45calcium (Ca) uptake were studied in saponin skinned rat caudal artery. The steady‐state Ca content increased when the free Ca concentration was varied from 10−8 to 10−4 M but was reduced by azide when the free Ca concentration exceeded 3.1 μM. The azide sensitivity and low affinity for Ca were consistent with functional mitochondria. The azide‐insensitive component consisted of a small bound and a larger releasable Ca fraction. After skinning in Triton X‐100, approximately 4 μmol Ca/kg wet tissue remained, which represented a tightly bound but slowly exchangeable Ca pool. The Ca content was independent of the free Ca concentration and MgATP, and it was not released with A‐23187 or Ca. The Ca content of the larger fraction was a higher order function of the free Ca concentration and was released with A‐23187, indicating it resided within a membrane‐bounded structure. Ca uptake by the releasable fraction was increased by oxalate, MgATP, phosphocreatine, temperature, phosphate, and ruthenium red and represents Ca sequestered by the sarcoplasmic reticulum (SR) with little contribution from other Ca binding or storage sites. It is described by the coefficients Umax = 96.94 μmol/kg wet tissue, K1/2 = 0.75 μM, and Hill coefficient = 1.70. The SR in this preparation regulates cytosolic Ca concentrations under physiological conditions and can accumulate Ca by MgATP‐dependent and MgATP‐independent processes. The larger, MgATP‐dependent Cauptake is described by the coefficients Umax = 72.87 μmol/kg wet tissue, K1/2 = 0.8 μM, and Hill coefficient = 2.09 and is consistent with Ca sequestered by the Ca‐transport ATPase of smooth muscle SR. The smaller, MgATP‐independent uptake is described by the coefficients Umax = 24.14 μmol/kg wet tissue, K1/2 = 0.56 μM, and Hill coefficient = 1.01 and represents Ca sequestered by an unidentified mechanism or by a subpopulation of SR.
Prosthetic Joint Infections in Patients Undergoing Carpal Tunnel Release

Introduction: Little information is available regarding the rate of prosthetic joint infections (PJIs) in patients undergoing carpal tunnel release (CTR) without antibiotic prophylaxis. Hand surgeons should be aware of patients’ history of arthroplasty. Methods: All patients who underwent CTR at our institution between 2012 and 2014 were identified and their charts were reviewed to identify those who had a history of total hip, knee, and/or shoulder arthroplasty. Further chart review consisted of identifying a history of PJI, use of perioperative antibiotics, and surgeon awareness of prior arthroplasty. Results: Two hundred seventy-five CTR surgeries were performed in patients who had previously undergone total joint arthroplasty (TJA). There were no PJIs in any group of patients (P = 0.01). Hand surgeon awareness of the presence of an arthroplasty history had no discernable effect on the choice to use antibiotics. Conclusions: There was a 0% rate of PJI in our series of patients with a history of TJA who underwent CTR. Overall hand surgeon awareness of TJA status was poor or poorly documented. Routine prophylactic antibiotics may not be indicated in patients undergoing CTR, even with the presence of a prosthetic joint. Level of Evidence: IV
Rituximab for IgG4-related disease: a prospective, open-label trial

Objectives To evaluate the efficacy of rituximab (RTX) in IgG4-related disease (IgG4-RD) in an open-label pilot trial. Methods We treated 30 IgG4-RD patients with two doses of RTX (1000 mg each). The participants were either treated with RTX alone (n = 26; 87%) or required to discontinue baseline glucocorticoids (GC) within 2 months (n = 4; 13%). Disease activity was measured by the IgG4-RD Responder Index (IgG4-RD RI) and physician's global assessment (PGA). Disease response was defined as the improvement of the IgG4-RD RI by two points. The primary outcome, measured at 6 months, was defined as: (1) decline of the IgG4-RD RI ≥2 points compared with baseline; (2) no disease flares before month 6; and (3) no GC use between months 2 and 6. Complete remission was defined as an IgG4-RD RI score of 0 with no GC use. Results Disease responses occurred in 97% of participants. The baseline IgG4-RD RI and PGA values, 11±7 and 63±22 mm, respectively, declined to 1±2 and 11±16 mm at 6 months (both p<0.00001). The primary outcome was achieved by 23 participants (77%). Fourteen (47%) were in complete remission at 6 months, and 12 (40%) remained in complete remission at 12 months. Among the 19 with elevated baseline serum IgG4, IgG4 concentrations declined from a mean of 911 mg/dL (range 138–4780 mg/dL) to 422 mg/dL (range 56–2410 mg/dL) at month 6 (p<0.05). However, only 8 (42%) of the 19 achieved normal values. Conclusions RTX appears to be an effective treatment for IgG4-RD, even without concomitant GC therapy. Trial registration number ClinicalTrials.gov identifier: NCT01584388.
Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3‐nitroproprionic acid in SK‐N‐SH human neuroblastoma cells

Mitochondria are recognized as modulators of neuronal viability during ischemia, hypoxia and toxic chemical exposure, wherein mitochondria dysfunction leading to ATP depletion may be a common pathway of cell death. Estrogens have been reported to be neuroprotective and proposed to play a role in the modulation of cerebral energy/glucose metabolism. To address the involvement of 17β‐estradiol preservation of mitochondrial function, we examined various markers of mitochondrial activity in human SK‐N‐SH neuroblastoma cells exposed to 3‐nitroproprionic acid (3‐NPA), a succinate dehydrogenase inhibitor which uncouples oxidative phosphorylation. 3‐NPA (10 mm) significantly increased ATP levels at 2 h then caused a 40% and a 50% decrease in ATP levels from baseline when treated for 12 h and 24 h, respectively. 3‐NPA also induced significant increases in levels of cellular hydrogen peroxide and peroxynitrite at 2 h and a 60% decrease in mitochondrial membrane potential (MMP) at 12 h exposure. 17β‐Estradiol (17β‐E2) pretreatment restored the ATP level back to 80% at 12 h of that in control cells treated with 3‐NPA but without E2, blunted the effect of 3‐NPA on MMP and reactive oxygen species levels. The present study indicates that 17β‐E2 can preserve mitochondrial function in the face of inhibition of oxidative phosphorylation.
Pilot signal design for coordinated transmission in massive MIMO systems

Massive multi-input multi-output (m-MIMO) and coordinated multipoint transmission (CoMP) are quite feasible techniques to improve the spectral efficiency in next generation wireless communication systems. It is of great concern to accurately estimate channel state information (CSI) of all base stations (BSs) involved in CoMP. Muting may be applied to improve the CSI estimation, which can reduce inter-cell interference during the estimation. However, it may require large resource for pilot signaling as the number of BSs in CoMP increases. When a m-MIMO technology is employed, it may require very large resource for pilot signaling. In this paper, we design the pilot signal for m-MIMO transmission with CoMP. The proposed scheme can improve CSI estimation, increasing the overall spectral efficiency of edge users. The performance of proposed scheme is verified by computer simulation.
Influence of the ultrasound pretreatment on anaerobic digestion of cattle manure, food waste and crude glycerine

ABSTRACT To increase the production of methane, when cattle manure (CM) is digested, pretreatments can be applied and/or the manure can be co-digested with other wastes. In this research work, a mixture of CM, food waste (FW) and raw glycerine (Gly) in a proportion in weight of 87% CM, 10% FW and 3% Gly was digested, (a) without pretreatment and (b) with pretreatment by ultrasound, applying a sonication energy of 1040 kJ/kg total solids. Specific methane production was 290 L CH4/kg volatile solids (VS) without pretreatment and 520 L CH4/kg VS with pretreatment. With respect to the volumetric methane production, 1.07 L CH4/Lreactor.day was produced in the first case, and in the second case, 1.98 L CH4/Lreactor.day. We can conclude that the application of ultrasound pretreatment significantly improved the production of biogas.
Statistical analysis of “Tail Bits” phenomena with defect clustering in RESET switching process of RRAM devices

Tail bits in the RESET process influence the distribution of resistive parameters, and will dramatically decrease the uniformity in high electric stimuli region. In this study, such phenomena can be explained as non-uniform distribution of defects in the insulating layer and high defects density in the bottleneck region of conductive filament (CF). Then departing from defects' distribution function, an improved statistical analysis is developed, exhibiting better feasibility than traditional Weibull method. Based on the results of statistical analysis, the predictable distribution of tail bits can be realized. Thus, targeted approaches at defect control are expected to implement on the improvement of RESET behavior in the future studies.
[Inhibins and Activin A in hypertensive Disorders of Pregnancy and HELLP-Syndrome].

OBJECTIVE Are serum concentrations of the ovarian glycoproteins inhibin A, inhibin B, pro-alpha-C and activin A different in normotensive, chronical hypertensive or pregancies complicated by preeclampsia or HELLP-syndrome? What are the clinical consequences? METHODS Serum concentrations of inhibin A, inhibin B, pro-alpha-C, and activin A of 99 women (37 normotensive patients, 23 patients with chronical hypertension, 25 women with preeclampsia and 14 patients with HELLP-syndrome) at different stages of pregnancy were determined by high specific ELISAS. RESULTS During pregnancy serum levels of all parameters increased continually and fell rapidly within parturition. Activin A and inhibin B levels showed significant higher serum concentrations in patients with preeclampsia and - even more pronounced - in patients with HELLP-syndrome. Normotensive and chronically hypertensive patients were not different. CONCLUSION Activin A and inhibin A appear to be viable candidates as laboratory parameters for detection of pregnancy induced hypertension. Maybe furthermore both parameters will allow the discrimination between chronic hypertension and hypertension induced by pregnancy.
Métropolisation et segmentations du territoire

Les dynamiques economiques et sociales sont a l'origine de la prosperite de l’agglomeration lyonnaise; en revanche, leur inscription territoriale a cette echelle comme a une echelle metropolitaine donne l’image d’un territoire segmente. La pression fonciere, le besoin d’espace et d’accessibilite a la main d’œuvre ont rapidement conduit a la division fonctionnelle de la ville industrielle, distinguant ainsi les « quartiers ouvriers proches des usines », situes a l’est et au sud en direction des vents dominants, des « beaux quartiers bourgeois de l’ouest et du centre », proteges et inaccessibles aux «classes laborieuses». L’afflux de la main d’œuvre et la multiplication des logements insalubres et des bidonvilles ont conduit a construire vite des habitations bon marche pour accueillir les familles defavorisees, en separant les fonctions urbaines et en renforcant ainsi la division de l’espace. La prosperite retrouvee lors des Trente Glorieuses a permis d’ameliorer les conditions de vie et de democratiser l’acces a la voiture pour les menages qui commencent a opter pour des localisations peripheriques. Le processus d’etalement urbain est deja enclenche et l’aire de fonctionnement de la ville depasse les decoupages administratifs. La crise des annees 1970 sonne le glas de trois decennies de croissance economique continue et de plein emploi, et ouvre une aire de desindustrialisation, de chomage et de mutations sociales qui s’accentuent a partir des annees 1980.
A Framework for Integrated Routing, Scheduling and Traffic Management in Adhoc Sensor Network

: A wireless Adhoc network is a decentralized wireless network. Each node is responsible for forwarding a data and finding a best route to reach to the destination. A new framework is introduced in the form of STORM which uses unicast and multicast routes and also it is fast and efficient for repairing the several routes. Unicast routing uses AODV or OLSR and for multicast routing ODMRP is used. STORM is an integration of scheduling, routing which are loop free and Traffic management by reserving a slot in a STORM frame in adhoc Sensor network. STORM gives better performance in real and elastic traffic also increases throughput and the capacity of channel, reduced the time delay and minimizing the bit error rate , in packet forwarding in network topology. STORM allows to transmit the packet in ordered form where each node may know the details of at least its 2 hop neighourbhood also in a particular time which packet is send and at what time is also schedule in wireless mesh network.
The modest software engineer

Autonomous decentralised systems must be dependable or they will be unhelpful, at best, and may cause serious harm. Despite major advances in theoretical computer science and software engineering, industrial practice has not kept pace and most software intensive system development projects fail. If we are to achieve the benefits promised by new system architectures, industry will have to adopt much more rigorous software engineering practices, and universities will have to extend the amount of software engineering they teach, and to use such methods routinely on their own projects.
Compartmentalization of the Adenosine Pool of Dog and Rat Hearts

Studies in rat and dog hearts examined the hypothesis that the cardiac adenosine pool contains an intracellular compartment. Enzymatically dispersed rat cardiocytes contain 70 pmol adenosine/mg protein which is resistant to 10 U/ml adenosine deaminase (ADA). Incubating dog heart homogenates for 1 minute at 37°C with 10 U ADA/mL did not change adenosine levels perceptibly from the average control value of 1.28 nmol/g. Studies employing [3H]hypoxanthine arabinoside as an adenosine surrogate showed that this nucleoside penetrates into pericardia! superfusates, attaining concentrations equal to those in blood plasma by 30 minutes. Since blood, cardiac interstitium, and pericardial superfusate are three compartments in series, this validates the use of pericardial superfusates equilibrated for ⩾30 min as probes of cardiac interstitial composition. In eight dogs, pericardial superfusate adenosine concentration averaged 0.24 μM. Cardiac muscle adenosine content averaged 0.87 nmol/g, indicating that the interstitial compartment accounts for only 6% of the cardiac pool. Dog cardiac muscle contains a [3H]adenosine binding protein whose size, affinity for adenosine analogs, and ability to synthesize S-adenosylhomocysteine (AdoHcy) suggest it is S-adenosylhomocysteine hydrolase (SAH). Studies employing a dog erythrocyte model show that adenosine is bound to a protein in this cell; treatment with L-homocysteine greatly reduces the amount of adenosine recovered. The half-time for the dissociation of [3H]adenosine from SAH at 37°C is 2.5 hours, and in the presence of ADA is >6 hours. Thus, although adenosine bound to SAH can serve as a substrate for AdoHcy synthesis, this experiment does not support the idea that the dissociation of adenosine occurs to a physiologically significant extent. Thus, we are uncertain of the functional role of the intracellular adenosine compartment.
Applications of EUS for the molecular characterization and treatment of gastrointestinal diseases--a review of the recent medical literature.

With the development of linear echoendoscopes, interventional endoscopic ultrasonography (EUS) has become a clinical reality. The widest application for interventional EUS is EUS-guided fine-needle aspiration (FNA). EUS-guided FNA is performed for sampling pancreatic masses, submucosal tumors, lymph nodes, perigastrointestinal masses, adrenal glands, and hilar lesions. [1–10] However, there has been ongoing interest by endosonographers in applying EUS-guided FNA beyond the already established applications.
Prediction of DGPS corrections with neural networks

Applies neural network modelling to predicting DGPS (Differential Global Positioning System) corrections. The paper first briefly introduces GPS and DGPS navigation principles and aircraft navigation performance requirements. Following a discussion of the temporal characteristics of the DGPS corrections, a technique for predicting the DGPS corrections based on diagonal recurrent neural network (DRNN) modelling is presented. Numerical examples show that the prediction accuracy is better than 1 m for 10 s prediction and 1.3 m for 30 s prediction, respectively, which can maintain the aircraft navigation at the required accuracy for a period of 30 s.
Balancing grief and survival: Experiences of children with brain tumors and their parents

ABSTRACT Psychosocial research about childhood brain tumors is limited because of varied abilities and prognoses, with children's voices largely absent. Research has focused on the impacts on families and their reactions; this qualitative study used constructivist grounded theory methods to explore experiences of childhood brain tumors from the perspectives of 12 children and 12 parents using semistructured interviews. Their stories illustrated efforts to maintain positivity and normalcy as they faced grief and uncertainty. The substantive grounded theory of balancing grief and survival offers a lens through which to view children's and parents' complex experiences, struggles, and coping strategies as integrated, dynamic processes.