Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Glucose Transporter 1 in Drug Delivery: Transporter, Receptor and/or Signaling Component

The targeting of cell surface molecules is a promising strategy in drug delivery. Glucose modifiednanocarrier interacts with glucose transporter 1 (GLUT1) as a target molecule and increases nanocarrier-drug internalization to cancer and brain endothelial cells. The mechanism by which GLUT1 promotes nanocarrier internalization remains unclear. Herein, we propose that the interaction of GLUT1 and nanocarrier absorbs and traps the nanocarrier and simultaneously activates cell signaling pathways that is responsible for activation of the endocytosis system.
“Amnesia” – Towards Machine Learning Models That Can Forget User Data Very Fast

Software systems that learn from user data with machine learning (ML) techniques have become ubiquitous over the last years. Recent law requires companies and institutions that process personal data to delete user data upon request (enacting the “right to be forgotten”). However, it is not suf-ﬁcient to merely delete the user data from databases. ML models that have been learnt from the stored data can be considered a lossy compressed version of the data, and therefore it can be argued that the user data must also be removed from them. Typically, this requires an ineﬃcient and costly retraining of the aﬀected ML models from scratch, as well as access to the original training data. We address this perfomance issue by formulating the problem of “decrementally” updating trained ML models to “for-get” the data of a user, and present eﬃcient decremental update procedures for three popular ML algorithms. In an experimental evaluation on synthetic data, we ﬁnd that our decremental update is two orders of magnitude faster than retraining the model without a particular user’s data in the majority of cases.
Vu Grounding Natural Language Inference on Images

Despite the surge of research interest in problems involving linguistic and visual information, exploring multimodal data for Natural Language Inference remains unexplored. Natural Language Inference, regarded as the basic step towards Natural Language Understanding, is extremely challenging due to the natural complexity of human languages. However, we believe this issue can be alleviated by using multimodal data. Given an image and its description, our proposed task is to determined whether a natural language hypothesis contradicts, entails or is neutral with regards to the image and its description. To address this problem, we develop a multimodal framework based on the Bilateral Multi-perspective Matching framework. Data is collected by mapping the SNLI dataset with the image dataset Flickr30k. The result dataset, made publicly available, has more than 565k instances. Experiments on this dataset show that the multimodal model outperforms the state-of-the-art textual model.
Processed Foods Promote Obesity

Obesity is one of the most widespread epidemics for all age groups, which increases the risk of health conditions including diabetes, hypertension, and cardiovascular disease. This is related to the increased consumption of processed foods and insufficient consumption of whole foods, such as fruits, vegetables, and whole grains. Higher rates of obesity are more prevalent in lower income homes, many of which may receive food stamps. The aim of this project is to inform food stamp recipients about how unhealthy processed food is through nutrition education.
Sensitivity of Stationary Shocks

Sensitivity of shocks to data is a key point for fluid-structure and flutter control. We show here on a simple example that the derivative of aerodynamic variables with shocks with respect to data are solutions of non-standard partial differential equations. We present also some constructive proofs of existence of solutions and a few simple numerical example.
EFFECT OF FUNGAL BIOCONTROL AGENTS AGAINST SEED-BORNE PATHOGENS IN VITRO AND UNDER GREENHOUSE CONDITIONS

The aim of this study was to check the efficiency of some biocontrol agents on controlling damping-off disease incited by the tested pathogens both in laboratory and under greenhouse conditions. Results obtained by radial growth technique indicated that all the tested FBA's significantly reduced growth of the seed-born pathogens. The highest reduction rates were obtained by the FBA T. harzianum (86.55%) followed by T. viride (81.33%). F. semitictum was the most sensitive compared with the other tested pathogens (79.77%), whereas M. phaseolina was the least sensitive to FBA treatments, where reduction rate attained (61.11%). T. koningii induced the lowest reduction rates (77.66%). Generally, treatment soil with the tested FBA's significantly reduced TIP values in cantaloupe cvs. T. harzianum was more efficient in reducing TIP than T. viride against all the tested seed-born pathogens, except with F. moniliforme. The highest reduction rates were detected in T. harzianum / F. semitictum in CREDO F1 treatment (81.81%). F. solani was the least sevsitive to FBA soil treatment, compared with the other tested cucurbit seedborne pathogens. In CREDO F1 cv. Reduction rates ranged from 65.62% to 77.27%. Both of FBA's soil treatment significantly reduced PRD values. Moreover, T. harzianum treatment realized the highest PRD reduction rates ranged from 57.14% (F. moniliforme) in CREDO F1 cv. to 83.33% (F. moniliforme) in ISI 54139 F1 cv. In ISI54139 F1 cv. , PRD reduction rates were 75.0% in T. harzianum / F. semitictum soil treatment to 83.33% in T. harzianum / F. moniliforme. T. viride was the most efficient in reducing PRD incited by F. semitictum with ANANAS cv. , and M. phaseolina with ISI54139 F1 cv. (80.0%). Soil treatment with the tested FBA's, in general, significantly reduced PTD incidence. In addition, T. harzianum was more efficient in reducing PTD by F. semitectum (100%) in CREDO F1 cv. , where reduction rates in T. harzianum / F. moniliforme and F. semitictum were 62.38% and 72.62%, respectively compared with control. In T. harzianum / F. solani or M. phaseolina treatments, equal rates were obtained (64.44%). T. viride was the most efficient in reducing PTD values in ISI 54139 F1 cv. inoculated with F. moniliforme (83.33%).
An in situ synchrotron study of the localized B2↔B19′ phase transformation in an Ni–Ti alloy subjected to uniaxial cyclic loading–unloading with incremental strains

High-resolution in situ synchrotron X-ray diffraction was applied to study a cold-drawn and solution-treated 56Ni–44Ti wt% alloy subjected to uniaxial cyclic loading–unloading with incremental strains. The micro-mechanical behaviour associated with the partial and repeated B2↔B19′ phase transformation at the centre of the sample gauge length was studied with respect to the macroscopic stress–strain response. The lattice strains of the (110)B2 and different B19′ grain families are affected by (i) the transformation strain, the load-bearing capacity of both phases and the strain continuity maintained at/near the B2–B19′ interfaces at the centre of the gauge length, and (ii) the extent of transformation along the gauge length. With cycling and incremental strains (i) the elastic lattice strain and plastic strain in the remnant (110)B2 grain family gradually saturate at early cycles, whereas the plastic strain in the B19′ phase continues to increase. This contributes to accumulation of residual strains (degradation in superelasticity), greater non-linearity and change in the shape of the macroscopic stress–strain curve from plateau type to curvilinear elastic. (ii) The initial 〈111〉B2 fibre texture transforms to [120]B19′, [130]B19′, [150]B19′ and [010]B19′ orientations. Further increase in the applied strain with cycling results in the development of [130]B19′, [102]B19′, [102]B19′, [100]B19′ and [100]B19′ orientations.
Assessment of Prevalence of Migraine and Associated Disability in Selected Urban Population of Ludhiana City in Punjab

Background: Neurological disorders are ranked as the leading cause of DALYs in 2015, most prevalent being tension-type headache, migraine, medication overuse headache, Alzheimer's disease and other dementias. Therefore, this community based cross sectional study was planned to determine the prevalence and disability due to migraine in the Urban Field Practice Area of Department of Community Medicine, DMCH, Ludhiana.
Har peroperativ lokal infiltrasjonsanestesi med Ropivacain betydning for smerteopplevelsen postoperativt for pasienter operert med primær totalprotese i hofteleddet

Background: The Local infiltration analgesic (LIA) technique has widely been used to reduce opioid requirements and improve postoperative mobilization following total hip arthroplasty (THA). However the evidence for LIA in THA remains to be clarified. Purpose: To evaluate whether a single shot LIA in addition to a multimodal analgesic regimen would reduce acute postoperative pain and opioid requirements after THA. Material and Methods: 116 patients undergoing primary THA under spinal anesthetic were included in this randomized doubleblinded placebocontrolled trial. All patients received oral opioid-sparing multimodal analgesia; Etoricoxib, Acetaminophen and Glucocorticoid. The patients were allocated to receive either 150 ml Ropivacain 2mg/ml and 1⁄2 ml Epinephrine 1mg/ml, or 150 ml saline 0. 9 %. Rescue analgesic consisted of Morphine and Oxycodone as needed. The primary endpoint was pain during mobilization in the recovery unit. Secondary endpoint was pain during mobilization the day after surgery and total postoperative opioid requirements the first postoperative day. Results: Pain during mobilization in the recovery unit did not differ significantly between the two groups (p=0. 7 Mann-Whitney U-test) neither did pain score during mobilization the day after surgery (p=0. 2 Mann-Whitney U-test). There were no significant difference between the two groups in postoperative consumption of opioids the first postoperative day. Conclusions: LIA provides no extra analgesic effect after THA in addition to the multimodal analgesic regimen used in this study.
PREPARATION AND EVALUATION OF HERBAL GEL FORMULATION

PREPARATION AND EVALUATION OF HERBAL GEL FORMULATION Mohsin J. Jamadar*, Rajmahammad Husen Shaikh Department of Quality Assurance, Pharmaceutics, Appasaheb Birnale College of pharmacy, Sangli. Maharashtra, India. 416416. Abstract:Herbal medicines is still the mainstay of about 75-80% of the world’s population, mainly in developing countries, for primary health care because of better cultural acceptability, better compatibility with human body and lesser side effects. Herbal medicines consist of plant or its part to treat injuries, disease or illnesses and are used to prevent and treat diseases and ailments or to promote health and healing. It is a drug or preparation made from a plant or plants and used for any to such purpose. Herbal medicines are the oldest form of health care known to mankind. Gel formulations prepared with Carbopol 934, HPMC K 100 M and Xanthan gum showed good homogeneity, no skin irritation, good stability and anti-inflammatory activity. However, the Xanthan gum based gel proved to the formula of choice, since it showed the highest percentage of extrudability, good spreadability and rheological properties. Formulation F5 with 1 % leaves extract and F11 with 1% root extract of Clerodendrum serratum showed the best formulation with significant anti-inflammatory activity. Formulation 5 and F11 shows approximately equal anti-inflammatory activity. Hence, there is no need to used roots for the preparation of medicines for anti-inflammatory action.
On the stationary Oseen equations in R

The stationary Oseen equations are studied in R3 in its general form, that is, with a non-constant divergenceless function on the convective term. We prove existence, uniqueness and regularity results in weighted Sobolev spaces. From this new approach, we also state existence, uniqueness and regularity results for the generalized Oseen model which describes the rotating flows. The proofs are based on Laplace, Stokes and Oseen theories.
Cameroon and potential of lactic acid bacteria to be used as diseases controlling agents

Aquaculture is the world’s fastest growing food production sector and can be a great solution to the massive demand for protein of animal due to increase in the Cameroonian population. This review summarizes the past and present status of fish aquaculture in Cameroon, the new challenges for intensifying fish production and evaluates the possibility of using lactic acid bacteria as disease control agents in order to overcome these challenges. Fish farming started in Cameroon in the late 1940s, and has seen little progress since the last ten years, but the production is still insufficient to meet the demand of the population estimated at 400 000 tons in 2015. In order to reduce massive fish imports, Cameroon plans to produce 100 000 tons of fish by commercial aquaculture. Achieving this task needs quality and quantity of fingerlings, and probiotic lactic acid bacteria instead of antibiotics could be used as disease control agents in young fish hatching and ponds in order to boost and ensure quality and quantity production.
X-ray Reflection Properties of Elastically Bent Perfect Crystals in Bragg Geometry

Reflection curves of bent crystals were calculated using the Takagi-Taupin theory of dependence on bending radius, wavelength, crystal thickness and Bragg angle. The reflection properties of bent crystals were measured for bending radii down to 90 mm. Usually, for the measurement of rocking curves of crystals with large bending radii, the double-crystal diffractometer was used in parallel position (n , -n) . A special achromatic diffractometer consisting of a plane and a bent crystal is proposed. It is used to measure rocking curves of bent crystals with small bending radii (R < l m). Experimental values show close agreement with the theory. The reflection properties are important for X-ray microscopy with two-dimensionally bent crystals and for X-ray spectroscopy with bent crystals.
HYDRO-CLIMATIC VARIABILITY IN SOUTHERN ECUADOR REFLECTED BY TREE-RING OXYGEN ISOTOPES

Variations of stable oxygen isotopes in tree-ring cellulose are a widely used proxy to reconstruct hydro-climate variability in tropical and subtropical regions. We present the first δ18O chronology from annual tree rings in tropical Cedrela montana trees growing in the mountain rain forest of the Podocarpus National Park (PNP) in southern Ecuador. The more than a century long data record (1885–2011) comes from up to 15 individual trees (1980–2005) and represents the bestreplicated isotope tree-ring chronology from the tropics. In comparison with tree-ring width, stable isotope variations show considerably higher correlations between individuals and thus represent a more reliable climate proxy in this very humid environment. High teleconnections to other stable isotope chronologies from the Amazon lowland indicate a high degree of consistency of regional hydro-climate variations. The PNP δ18O record is correlated with seasonal precipitation (January to April, CRU TS 3.21), frequency of wet days, and cloud cover over the Andean Cordillera Real. Spatial correlations indicate that the El Niño-Southern Oscillation (ENSO) has strong impact on tree-ring δ18O variations. Sea Surface Temperatures (SSTs) of the Niño 3.4 region and Niño 4 region, and the Oceanic Niño Index (ONI) show strong positive correlations with Cedrela oxygen isotope ratios, whereas the ENSO precipitation index correlates negatively. The Niño 3.4 and 4 SST influence is stronger after 1960 than before, indicating a shift in the influence of the Pacific Ocean on moisture variations in the Ecuadorian Andes. In the same period, the positive correlation with oxygen isotope signals from Andean glacier ice cores (r=0.2; p<0.05, 1894–1993) increased strongly (r=0.51; p<0.01, 1960–1993). In conclusion, stable oxygen isotope series from tropical tree species can help reconstruct variations in the hydroclimate of the Andean mountains and their surrounding areas.
Remote Sensing Single-Image Resolution Improvement Using A Deep Gradient-Aware Network with Image-Specific Enhancement

Super-resolution (SR) is able to improve the spatial resolution of remote sensing images, which is critical for many practical applications such as fine urban monitoring. In this paper, a new single-image SR method, deep gradient-aware network with image-specific enhancement (DGANet-ISE) was proposed to improve the spatial resolution of remote sensing images. First, DGANet was proposed to model the complex relationship between low-and high-resolution images. A new gradient-aware loss was designed in the training phase to preserve more gradient details in super-resolved remote sensing images. Then, the ISE approach was proposed in the testing phase to further improve the SR performance. By using the specific features of each test image, ISE can further boost the generalization capability and adaptability of our method on inexperienced datasets. Finally, three datasets were used to verify the effectiveness of our method. The results indicate that DGANet-ISE outperforms the other 14 methods in the remote sensing image SR, and the cross-database test results demonstrate that our method exhibits satisfactory generalization performance in adapting to new data.
Analysis of Directional Beam Patterns from Firefly Optimization

An analysis of the positional distributions of the elements of a linear antenna array is conducted. The movemen t and clustering of fireflies based on their intensity is applied as an optimization technique to determine the element positionsthat achieve a desired radiation pattern, consisting of a main be am bandwidth and sidelobe level. The expected value and varian ce of the resulting beam pattern with respect to angular positionand probability distribution of inter-element distances as the number of elements are discussed. It is shown that the distributionfor inter-element distances that meet the desired radiation pa ttern yields a bimodal structure, one where arrays consisting of ahigh number of elements experience clustering, with elements ha ving a higher probability of being spaced closer together. I. M OTIVATION Nonuniformly spaced antenna arrays may achieve desired beamforms using constant current through proper positioni ng of the individual elements. This has many applications due to the miniaturization of transducers, coupled with their e conomic viability, that allows a great many of them to be placed in an array. Individual elements may then be activated in accordance with a specific inter-element distance distribu tion that ensures the array produces a specified beamform. Applications of this are arrays consisting of wireless node s where a nonuniform spacing offers robust performance [1] and low power wireless sensor networks [2]. The analysis of nonuniformly spaced wireless elements in a one dimensional array is conducted in this work. II. I NTRODUCTION Consider an antenna array that is composed of 2M elements positioned symmetrically about the origin on the x-axis in three-dimensional space. The beam pattern in the x− y plane is described with respect to the angle φ as,
Transcranial parenhymal sonography in the diagnosis of Parkinson's disease

Bacground/Aim. Modern ultrasound systems allow highresolution transcranial sonography (TCS) of the brain structures. Enlargement of the echogenic signal (hyperechogenicity) of the substantia nigra (SN) has been reported as a highly characteristic finding in idiopathic Parkinson's disease (PD) and is thought to reflect increased amounts of iron, bound to proteins other than ferritin, in the SN in the course of neurodegeneration. The aim of our study was to investigate the prevalence of the SN hyperechogenicity in PD patients, as well as its possible clinical correlates. Methods. The study comprised 103 consecutive PD patients and 50 healthy age-matched controls. For TCS examination a color-coded, phased array ultrasound system equipped with a 2.5 MHz transducer was used (ESAOTE Technos MP, Italia). The examination was performed through a preauricular acoustic bone window with a penetration depth of 16 cm and a dynamic range of 45-50 dB. The SN was identified within the butterfly shaped structure of the mesencephalic brainstem, with scanning from both temporal windows. Results. The SN hyperechogenicity was identified in 95 out of 103 examined PD patients (92%), which was marked in 60 (63%), and moderate in 35 patients (37%). Median SN echogenic size was larger contralateral to the clinically more affected side of the body. Unilateral SN hyperechogenicity was also found in 5 out of 50 healthy controls (10%). No ventricular enlargements were notified in our study. Conclusion. Our study demonstrated SN hyperechogenicity in more than 90% of PD patients. In adult subjects without neurological symptoms, the TCS finding of at least unilaterally marked SN hyperechogenicity indicates a subclinical functional impairment of the nigrostriatal dopaminergic system.
Test strip handling for the screening of drugs of abuse in the clinical toxicological setting

Abstract Test strips for detecting narcotics are being used morefrequently – ranging from clinical issues to forensicallyrelevant cases. Analyses are not always done by stafftrained in toxicology. Pharmacological and toxicologicalknowledge is necessary for the interpretation of theresults as well as the technical understanding of the testsystem (e.g., cut-off values, cross reactivity). False neg-ative results have to be considered possible when inter-preting results. Suitable measures should be taken toruleout sample manipulation to the widest extent possible.To ensure the accuracy and reproducibility of analyticalresults, quality checks will have to be carried out. Ana-lytical results will be reproducible only when backed upby the necessary documentation. Further diagnosisinvolving chromatographic methods should be carriedout to differentiate and confirm positive findings.Nationaland international rules and regulations regardingdecisionlimits should be observed. Keywords: confirmation testing; cross reactivity; deci-sion limits; drugs; metabolism; quality control; test strips.
Circularly Polarized Filtering Dielectric Resonator Antenna

A circularly polarized (CP) filtering dielectric resonator antenna (DRA) is investigated in this paper. The DRA is fed by a cross slot to produce CP radiation. A parasitic rectangular patch is introduced on the top of DRA to improve the impedance matching and CP purity of the antenna, while a novel microstrip feedline is used to generate radiation nulls at the passband edges and thus forming a quasi-bandpass filtering response. The design obtains an impedance bandwidth of 6.5% (19.3-20.6 GHz) and an axial ratio (AR) bandwidth of 7.1% (19.0-20.4 GHz). Therefore, an overlapping bandwidth of 5.5% is achieved, ranging from 19.3 to 20.4 GHz. Moreover, the realized gain of the antenna is stable within the working passband, with the maximum and minimum gains given by 8 and 7.7 dBic respectively. Outside the passband, the radiation suppression levels are more than 21 and 18 dB at the lower and higher frequencies.
It ain’t what you do, it’s the way that you do it.

Empirical research was conducted in twelve service organisations to understand the impact of internal strategic fit on business performance. The findings suggest that the approach used to create fit has a more significant than the level of fit it creates. A review of the high performing companies showed they used ‘strategic frameworks’ in stable price-sensitive markets, ‘service/product-based teams’ in stable design-led markets, ‘flexible resources’ in unstable price-sensitive markets and ‘customer-based teams’ in unstable design-led markets.