Miracle-dz/UniFAR-FTUs huggingface dataset:
Written individualised management plans for asthma in children and adults.

BACKGROUND Non-adherence to treatment advice is a common phenomenon in asthma and may account for a significant proportion of the morbidity. Comprehensive care that includes asthma education, written self-management plan and regular review has been shown to improve asthma outcomes, but the contribution of these components has not been established. OBJECTIVES To determine whether the provision of a written asthma self-management plan increases adherence and improves outcome. SEARCH STRATEGY A search was carried out on the Cochrane Airways Group trials register. There was no language restriction. The search of the databases used the following terms: action plan OR self OR self-care OR self-manag* OR educ* AND adher* OR comply OR compli*. Authors of included studies were contacted for any unpublished or on-going studies and bibliographies of all included studies and reviews were searched for further studies. SELECTION CRITERIA Only randomised controlled trials (RCTs) in patients with asthma were considered. Participants must have been assigned to receive an individualised written asthma management plan (symptom or peak flow based) about the actions required for regular asthma management and/or the actions to take in the event of an asthma exacerbation. DATA COLLECTION AND ANALYSIS Study quality was assessed and data abstracted by two reviewers independently. MAIN RESULTS Six trials met the inclusion criteria. The written management plans were either peak flow or symptom based, which were compared against each other or compared to no written management plan. Reported outcomes included: hospitalisation, emergency department visits, oral corticosteroid use, lung function, days lost from school/work, unscheduled doctor visits and respiratory tract infections. There was no consistent evidence that written plans produced better patient outcomes than no written plan. For some outcomes, there appeared to an advantage of one type of plan over the other, but there was no consistency - one type of plan was not consistently more effective than another. REVIEWER'S CONCLUSIONS The available trials are too small and the results too inconsistent to form any firm conclusions as to the contribution of written self management plans in the known beneficial effects of a comprehensive asthma care programmes.
Myosin Vb and Rab11a regulate phosphorylation of ezrin in enterocytes

ABSTRACT Microvilli at the apical surface of enterocytes allow the efficient absorption of nutrients in the intestine. Ezrin activation by its phosphorylation at T567 is important for microvilli development, but how such ezrin phosphorylation is controlled is not well understood. We demonstrate that a subset of kinases that phosphorylate ezrin closely co-distributes with apical recycling endosome marker Rab11a in the subapical domain. Expression of dominant-negative Rab11a mutant or depletion of the Rab11a-binding motor protein myosin Vb prevents the subapical enrichment of Rab11a and these kinases and inhibits ezrin phosphorylation and microvilli development, without affecting the polarized distribution of ezrin itself. We observe a similar loss of the subapical enrichment of Rab11a and the kinases and reduced phosphorylation of ezrin in microvillus inclusion disease, which is associated with MYO5B mutations, intestinal microvilli atrophy and malabsorption. Thus, part of the machinery for ezrin activation depends on recycling endosomes controlled by myosin Vb and Rab11a which, we propose, might act as subapical signaling platforms that enterocytes use to regulate development of microvilli and maintain human intestinal function.
Sources , Detectors and Receivers Semiconductor , Superconductor and Other v Moderate-Power W-Band Cerenkov Traveling-Wave Amplifier

A compact W-band (95 GHz) traveling-wave amplifier design is discussed, in which the slow wave circuit consists of a smooth rectangular waveguide with ceramic dielectric lined side walls. Small-signal performance for the 15kV, 0.33-A device is predicted to include 30-dB gain for a 7.4cm long circuit, -500 W output, 2 GHz instantaneous bandwidth, and 13 GHz voltage-tunable bandwidth. A 2-3 kG solenoidal magnetic field is required for beam focusing. Rectangular geometry for the slow wave circuit allows for longitudinal splitting of the circuit, thus permitting precision fabrication and suppression of non-symmetric competing modes.
Examining User Acceptance of Computer Technology: An Empirical Study of Student-Teachers in Kenya

The use of computer technology in schools has made slow progress even though the government has been generous in funding as evidenced in the Kenya Education Sector Support Programme (KESSP). It is therefore important to understand how and when teachers use computer technology in order to devise implementation strategies to encourage them. This study investigated student teachers’ perceptions of computer technology in relation to their intention to use computers. The purpose is to shed light on more effective ways to promote the use of computer technology in schools. Based on an expanded variation of the Technology Acceptance Model, a survey of student teachers’ perceptions were collected at local universities in Kenya. Overall, the results indicated that: (1) student teachers perceived usefulness of computer technology had a direct significant effect on their intention to use it; (2) student teachers perceived ease of use had only an indirect significant effect on intention to use; however, (3) student teachers’ subjective norm, that is the possible influence of external expectations, did not have any direct or indirect significant effects on their intention to use computer technology.
Immune-Mediated Mechanisms of Parasite Tissue Sequestration during Experimental Cerebral Malaria

Cerebral malaria is a severe complication of malaria. Sequestration of parasitized RBCs in brain microvasculature is associated with disease pathogenesis, but our understanding of this process is incomplete. In this study, we examined parasite tissue sequestration in an experimental model of cerebral malaria (ECM). We show that a rapid increase in parasite biomass is strongly associated with the induction of ECM, mediated by IFN-γ and lymphotoxin α, whereas TNF and IL-10 limit this process. Crucially, we discovered that host CD4+ and CD8+ T cells promote parasite accumulation in vital organs, including the brain. Modulation of CD4+ T cell responses by helminth coinfection amplified CD4+ T cell-mediated parasite sequestration, whereas vaccination could generate CD4+ T cells that reduced parasite biomass and prevented ECM. These findings provide novel insights into immune-mediated mechanisms of ECM pathogenesis and highlight the potential of T cells to both prevent and promote infectious diseases.
The Determinants of Successful Bank Profitability in Indonesia: Empirical Study for Provincial Government’s Banks and Private Non-Foreign Banks

The purpose of this research is to investigate factors that determine Commercial Bank’s Performance and Profitability, especially among Provincial Government’s Banks and Private Non-Foreign Exchange Banks in Indonesia for the period of 1993-2000. Return on Assets and Return on Equity were used as the proxies for the profitability. This research applies cross sectional and pooled data. Data was obtained from Indonesia Banking Directory which was published by Bank Indonesia. This paper studies some financial ratios particularly used in banking Industry and some macroeconomic indicators which are hypothesized significantly affecting the profitability. Macroeconomic Indicators are also used to assess the degree of relationship among variables and their fluctuations. Statistics and econometrics are employed to find the fittest model. The result of this research has shown that TETA (Total Expenses to Total Assets and CRTA (Capital and Reserves to Total Assets) dominantly and consistently affect ROA and ROE. In General, it can be concluded that cost management, capital adequacy, and assets and liabilities management are the most important factors that determine the bank’s profitability.
Drug and alcohol abuse and cholesterol levels

Abstract An uncontrolled, retrospective study of 58 consecutive patients admitted to a hospital substance abuse unit assessed the effects of alcohol consumption on cholesterol levels. From the dietary histories completed by 54 of the patients, it was found that the alcoholics consumed a high-calorie diet containing a high percentage of foods with a high cholesterol content, but in small quantities. Most of their caloric intake was derived from the alcohoL Abusers of substances other than alcohol had a low-calorie intake of the same quality as alcoholics. It appears that low consumption of alcohol rather than something intrinsic in alcohol or other drugs is related to low levels of total cholesterol in persons consuming a high cholesterol-containing diet. The author also suggests that an unexplained relationship between low cholesterol levels and some gastrointestinal malignancies may be due to the effects of alcohol on the gastrointestinal tract.
A Study of the impact of the Musoma Resolution on students personnel services at the University of Dar es Salaam

In November, 1974, the National Executive Committee of the Tanganyika Afncan National Union (TANU) met in Musoma to review Tanzania's. progress in its policies of Socialism and Self.Reliance. Some profound deficiencies were spotted in the Implementation of the policy of Education for SelfReliance, especially at post secondary level. It was resolv(:d at that time: that, from thlm on, formal education would basically end at the secondary Sch901level. Secondary school graduates would serve one year in the National Service. Following National Service, these graduates would work several years before. they would be admitted to any post secondary institution. Post secondary institutions were, therefore, declared open for adult workers and peasants who satisfied the minimum entry qualifications (Msekwa, 1975). The applicants had either to pass the University of Dar es Salaam Mature ~ge Entrance Examination and "produce a strong recommendation by their . employers and TANU! ASP (Tanganyika African National Union/Afro .Shiraz Party) branches, regarding their suitability (in terms of character and general work performance and commitment for further training at university level"
Firms, Markets and Economic Change: A dynamic Theory of Business Institutions

Traditonal western forms of corporate organization have been called into question by the success of Japanese keiretsu. Firms, Markets and Economic Change draws on industrial economics, business strategy, and economic history to develop an evolutionary model to show when innovation is best undertaken. The authors argue that innovation is a complex process that defies neat categorization and government policy should be to facilitate change rather than to direct it.
Optimal Trading Strategies: Quantitative Approaches for Managing Market Impact and Trading Risk

"1. Transaction Cost 2. Unbundled Trading Costs 3. Pre-Trade Analysis 4. Price Appreciation 5. Market Impact 6. Timing Risk 7. Opportunity Cost 8. The Holy Grail of Market Impact 9. Optimal Trading Strategies 10. Principal Bid Transactions 11. VWAP Trading Strategies 12. Advanced Trading Techniques 13. Post Trade Analysis"
Transcorneal electrical stimulation promotes the survival of photoreceptors and preserves retinal function in royal college of surgeons rats.

PURPOSE To determine whether transcorneal electrical stimulation (TES) has neuroprotective effects on photoreceptors and preserves retinal function in Royal College of Surgeons (RCS) rats. METHODS Three-week-old RCS rats received TES through a contact lens electrode on the left eye weekly for 2 to 6 weeks. The right eyes received sham stimulation on the same days. Electroretinograms (ERGs) were recorded from the rats at 3 weeks (before TES), and at 5, 7, and 9 weeks of age. After the ERG recordings, the rats were killed for morphologic analyses of the retina. RESULTS Morphologic analyses showed that the mean thickness of the outer nuclear layer (ONL) at each time point was significantly thicker in eyes treated with TES of 100 muA than in eyes with sham stimulation (TES 100 muA versus sham: 5, 7, and 9 weeks of age; P < 0.001). ERG studies showed that TES also significantly preserved retinal function up to 7 weeks of age, but did not preserve retinal function at 9 weeks of age. CONCLUSIONS TES prolongs the survival of photoreceptors and delays the decrease of retinal function in RCS rats. Although further investigations are necessary before using TES on patients, these findings indicate that TES may be a therapeutic treatment for some patients with diseases of the photoreceptors such as retinitis pigmentosa.
Abhinav International Monthly Refereed Journal of Research in Management & Technology IS EMPLOYER BRANDING THE NEED OF THE HOUR? A STUDY OF ITS SIGNIFICANCE TO ATTRACT, RECRUIT AND RETAIN POTENTIAL CANDIDATES

In the modern recruiting landscape the word ‘War for Talent’ aptly describes the shift of focus from talent being viewed as a regular resource to talent being seen as a strategic resource to gain competitive advantage. In today’s environment of cut-throat competition it is hard for organizations to attract and maintain the best candidates. The organizations use various methods to recruit and hire, but in today’s fast changing corporate world it is time to use the organization’s brand to attract talents the organization would like. This article will support concept of employer brand as the organization’s image, as an exceptional place to work in the minds of the current employees as well as potential candidates, clients, customers. This study showcases how to use the organization’s brand to attract, retain, and engage the people it needs. In today’s competitive world it has become essential to evaluate whether an organisation or for that matter any organisation is using correctly its strong powers to attract and retain the best candidates. The employer brand is the value proposition that organization conveys its employees and the external labour market. Great organizations create such a strong brand that it draws the talent to them rather than having to spend significant time and money on selling the organization to the talent market. There are many benefits of recruiting that are provided by a strong employment brand.
Auditing Personal Information Management

This paper firstly introduces personal information management using computers. It then describes a suggested approach to auditing the information needs which are personal to a knowledge worker. As part of an overall research programme in personal information management, the paper describes a personal auditing approach which is positioned as part of the experimental research aspect of the overall research. The paper aims to give practical guidance including on the effective classification of an individual’s data.
Processes Underlying Mexican-Origin Adolescent Mothers’ BMI

Objective: To examine potential mediating and moderating factors in the longitudinal association between contextual stressors (economic hardship, ethnic discrimination) and subsequent engagement in risky behaviors and body mass index (BMI) of Mexican-origin adolescent mothers. Method: Participants were Mexican-origin adolescent mothers (N = 204) who were recruited from community agencies and high schools in a Southwestern metropolitan area. Contextual stressors and risky behaviors were assessed 3 and 4 years postpartum. Adolescent mothers’ BMI was assessed 5-years postpartum. Path analyses assessed moderated mediation with risky behaviors as a mediator of associations between contextual stressors and BMI, and family and friend support as moderators of the mediated pathways. Results: At low levels of family support, economic hardship at 3-years postpartum positively predicted engagement in risky behaviors at 4-years postpartum, which in turn positively predicted BMI at 5-years postpartum. At high levels of family support, all relations were not significant. At low levels of friend support, ethnic discrimination at 3-years postpartum positively predicted engagement in risky behaviors at 4-years postpartum, which in turn positively predicted BMI at 5-years postpartum. At high levels of friend support, all relations were not significant. Conclusions: Among adolescent mothers who receive low levels of family and friend support, engagement in risky behaviors may function as a mechanism through which contextual stressors are linked to adolescent mothers’ BMI. Findings have implications for prevention efforts aimed at attenuating unhealthy weight status among Mexican-origin adolescent mothers by reducing engagement in risky behaviors and bolstering family and friend support.
The extracellular matrix in epithelial biology: shared molecules and common themes in distant phyla.

Epithelia are polarized structures, asymmetric by definition because they represent the boundary between what is topologically inside and what is outside an organism. Epithelial cells provide a physical barrier with the outside world and regulate bidirectional chemical exchange, as in absorption of nutrients or oxygen and secretion of wastes or other materials. Such cells are extremely varied and ancient, being found in multiple forms within most organs and in all animal taxa. Epithelia form specialized three-dimensional structures suited to their physiological role, such as the highly branched structures seen in many secretory organs, the flattened bilayer of cells in the wings of a fly, or the stratified layers of cells in vertebrate skin. These tissues are distinctive not just in the forms the cells assume, but also in the nature and structure of the extracellular matrix (ECM) deposited asymmetrically adjacent to the epithelial sheet. Epithelial histogenesis, the development of these elaborate structures, requires cells to regulate their pattern of gene expression, their cell cycle status and rate of apoptosis, their shape, and their motility. They must also respond to soluble factors such as cytokines and interact with other cell types, both epithelial and mesenchymal. In the course of these structural and functional changes, cells interconvert between epithelial and mesenchymal phenotypes, a transition that is seen repeatedly, starting in early development.
Partial trisomy 1q41‐qter and partial trisomy 9pter‐9q21.32 in a newborn infant: An array CGH analysis and review

We report on a girl who presented with distinctive abducted hip and hyperextended knee. Cytogenetic analysis detected an extra derivative chromosome resulting from a balanced translocation in the mother and 3:1 segregation. Using array comparative genomic hybridization (CGH) in combination with conventional high resolution GTG banding, we designate the karyotype as 47, XX, +der(9)t(1;9)(q41;q21.32)mat, indicating tertiary trisomy of chromosome segments 1q41‐qter and 9pter‐9q21.32. A review and genotype–phenotype correlation suggested that the patient represented most of the manifestations of duplication of chromosome arms 1q and 9p. To our knowledge, a similar case has so far not been reported. © 2013 Wiley Periodicals, Inc.
Technological Frames and End-User Computing

This present study is targeted at examining why end-user computing does not live up to its expected promises. Why is there this notion that end-users, MIS personnel and management are generally dissatisfied with end-user computing? We propose to investigate these questions based on the work that has been done on technological frames. The combination of inexpensive personal computers and easy-to-use software packages has resulted in the emergence of a phenomenon now known as end-user computing (EUC). The early 80's saw the rapid proliferation of personal computers in corporate computing. In the years since, the roles of both the producers and the consumers of MIS have changed dramatically; blending and intertwining until it is almost impossible to tell the two groups apart. Before the advent of PC's, the MIS department had full responsibility for the entire system: they were the producers. The end-users had little if any responsibility for the creation or design of the systems they ultimately used; they were the consumers. Today, the end-users can be responsible for all aspects of the systems they use; everything from choosing the software and the hardware, installing the package, and creating the system. The MIS department typically is now only involved in main frame applications, having little responsibility or involvement on systems running on PCs. This drastic change in roles has occurred in the relatively short time frame of 10 to 15 years. While the actual roles played by the two groups might have physically changed, the changes in the frames of reference they hold regarding their roles may not have changed at exactly the same pace. In addition to the changes in the roles played by the users and the IS department, another change has occurred in the skill sets and perspectives that are brought to the relationship by the two groups. In the old environment, the users possessed the business knowledge, and the IS department possessed the technical expertise. The partnership was based on the complementary nature of the two skill sets, and the results were systems that were built to the specifications of the users using the expertise of the IS professionals. In the new environment, many end-users come to the relationship with a significant amount
Acute Complications of Preeclampsia

Preeclampsia is an idiopathic multisystem disorder specific to human pregnancy and the puerperium. More precisely, it is a disease of the placenta, because it has also been described in pregnancies where there is trophoblast but no fetal tissue (complete molar pregnancies). Although the pathophysiology of preeclampsia is poorly understood, it is clear that the blueprint for its development is laid down early in pregnancy. It has been suggested that the pathologic hallmark is a complete or partial failure of the second wave of trophoblast invasion from 16 to 20 weeks’ gestation, which is responsible in normal pregnancies for destruction of the muscularis layer of the spiral arterioles. As pregnancy progresses, the metabolic demands of the fetoplacental unit increase. However, because of the abnormally shallow invasion of the placenta, the spiral arterioles are unable to dilate to accommodate the required increase in blood flow, resulting in “placental dysfunction” that manifests clinically as preeclampsia. Although attractive, this hypothesis remains to be validated. Preeclampsia is a clinical diagnosis. The classic definition of preeclampsia encompasses three elements: new-onset hypertension (defined as a sustained sitting blood pressure ! 140/90 mm Hg in a previously normotensive woman); new-onset proteinuria (defined as >300 mg/24 hours or ! 2+ on a clean-catch urinalysis in the absence of urinary tract infection); and new-onset significant nondependent edema. However, more recent consensus reports have suggested eliminating edema as a criterion for the diagnosis. A more extensive synopsis of preeclampsia is beyond the scope of this discussion. This monograph serves to review in detail the diagnosis and management of several acute maternal complications of preeclampsia: eclampsia, HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome, liver rupture, pulmonary edema, renal failure, disseminated intravascular coagulopathy (DIC), hypertensive emergency, and hypertensive encephalopathy and cortical blindness. Correspondence: Errol R. Norwitz, MD, PhD, Department of Obstetrics & Gynecology, Brigham & Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115. E-mail: enorwitz@partners.org PROD. # GRF20214