Miracle-dz/UniFAR-FTUs huggingface dataset:
Initial Crestal Bone Loss After Implant Placement with Flapped or Flapless Surgery-A Prospective Cohort Study.

PURPOSE Some initial loss of bone around dental implants is generally expected. There is reason to believe that reflecting a mucoperiosteal flap promotes crestal bone loss in the initial phase after an implant has been inserted. The objective of this study was to compare the effect of flapless implant insertion on initial bone loss with that of conventional placement after elevation of a mucoperiosteal flap. MATERIALS AND METHODS Eighty patients were randomly assigned either to the flapless group (test) or to the group with a full-thickness flap (control). In total, 195 implants were included in the study: 95 of these were inserted flapless (test group), and 100 were inserted by raising a mucoperiosteal flap (control group). Healing occurred unsubmerged for both groups. To assess changes in the peri-implant bone level, the height of the mesial and distal peri-implant bone was measured on digitally calibrated radiographs taken at the time of implant placement and 12 months afterward. RESULTS After 1 year, a mean cumulative crestal bone loss of 0.24 ± 0.62 mm was measured. A mean bone loss of 0.55 ± 0.57 mm was found in the group with the mucoperiosteal flap, while a slight mean gain in bone height of 0.09 ± 0.49 mm was found in the test group, a statistically significant difference (P < .001). CONCLUSION Flapless implant insertion caused less peri-implant bone loss than implant insertion with flap preparation. Therefore, the flapless procedure represents a protective and promising method in implant surgery.
Neonatal systemic candidiasis treated with miconazole.

recommendations for hydrallazine therapy and previous evidence.1 3 One report is consistent with our experience.5 Autoimmune phenomena were also more frequent in asymptomatic slow acetylators receiving 200 mg hydrallazine a day or less. This has previously been reported only in patients taking over 200 mg hydrallazine daily.2 Our study indicates that conventionally "safe" doses of hydrallazine may cause both asymptomatic autoimmune phenomena and a lupus syndrome which is not always mild or transient and may require steroids. Potentially serious hydrallazine toxicity is a possibility in all patients taking this drug even after many months of uncomplicated treatment, but especially in slow acetylators in whom constant vigilance for early symptoms is necessary.
Vitamin E and cognitive decline in older persons.

BACKGROUND Previous studies raise the possibility that antioxidants protect against neurodegenerative diseases. OBJECTIVE To examine whether intake of antioxidant nutrients, including vitamin E, vitamin C, and carotene, is associated with reduced cognitive decline with age. DESIGN Longitudinal population-based study conducted from September 17, 1993, to November 20, 2000, with an average follow-up of 3.2 years. PATIENTS The patients were 2889 community residents, aged 65 to 102 years, who completed a food frequency questionnaire, on average 18 months after baseline. MAIN OUTCOME MEASURE Cognitive change as measured by 4 tests (the East Boston Memory Test, which tests immediate and delayed recall; the Mini-Mental State Examination; and the Symbol Digit Modalities Test) at baseline and 3 years for all participants, and at 6 months for 288 randomly selected participants. RESULTS We used random-effects models to estimate nutrient effects on individual change in the average score of the 4 cognitive tests. The cognitive score declined on average by 5.0 x 10(-2) standardized units per year. There was a 36% reduction in the rate of decline among persons in the highest quintile of total vitamin E intake (-4.3 x 10(-2) standardized units per year) compared with those in the lowest quintile (-6.7 x 10(-2) standardized units per year) (P =.05), in a model adjusted for age, race, sex, educational level, current smoking, alcohol consumption, total calorie (energy) intake, and total intakes of vitamin C, carotene, and vitamin A. We also observed a reduced decline with higher vitamin E intake from foods (P =.03 for trend). There was little evidence of association with vitamin C or carotene intake. CONCLUSION Vitamin E intake, from foods or supplements, is associated with less cognitive decline with age.
A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis.

OBJECTIVE To study the occurrence and function of polymorphism in the human glucocorticoid receptor (hGR) gene in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). METHODS We used single stranded conformation polymorphism (SSCP) and direct sequencing to study the hGR gene in 30 patients with RA, 40 with SLE, and 24 controls. A newly identified polymorphism was transfected in COS-1 cells and the stability of the mRNA containing the polymorphism was tested using real-time PCR. RESULTS A polymorphism in the hGR gene in exon9beta, in an "ATTTA" motif, was found to be significantly associated with RA. Introduction of this polymorphism in the hGRb mRNA was found to significantly increase stability in vitro compared to the wild-type sequence. CONCLUSION Our findings show an association between RA and a previously unreported polymorphism in the hGR gene. This polymorphism increased stability of hGRbeta mRNA, which could contribute to an altered glucocorticoid sensitivity since the hGRbeta is thought to function as an inhibitor of hGRalpha activity.
Enabling Cloud Storage to Support Traditional Applications

We have presented the idea of enabling the cloud storage to support traditional applications. In this way, the applications running in local host can be deployed and running on the cloud storage without any modification. An acceptable solution is to enhance current cloud storage with standard POSIX file system interface. So that it can benefit from the scalable capacity of existing cloud storage and compatible interface of traditional file systems. With this point in mind, we designed and implemented the PosixCloud, a general purpose scalable storage cloud with standard POSIX interface for traditional end users. Similar to other cloud storage systems, the PosixCloud is designed to be chunk based data layout, built on commodity computers, chunk replication for reliability and so on. However, the metadata in our system is managed in distributed database instead of the memory single master. So that the metadata scalability of our system is enhanced and large small files can be handled without introducing high overhead. The paper describes the details of the design and implementation of PosixCloud. Also, we evaluate the POSIX compliance, functionality, data and metadata performance of PosixCloud by both test suits of third parties and customized experiments. The results demonstrate that our system can achieve reasonable performance and meet the storage requirement of most traditional applications.
Novel indole-2-carboxamide compounds are potent 2 broad spectrum antivirals active against western 3 equine encephalitis virus in vivo 4 5 6 7

1 Novel indole-2-carboxamide compounds are potent 2 broad spectrum antivirals active against western 3 equine encephalitis virus in vivo 4 5 6 7 Phillip C. Delekta, Craig J. Dobry, Janice A. Sindac, Scott J. Barraza, Pennelope K. Blakely, 8 Jianming Xiang, Paul D. Kirchhoff, Richard F. Keep, David N. Irani, Scott D. Larsen, and 9 David J. Miller 10 11 12 13 Departments of Internal Medicine, Medicinal Chemistry, Neurology, Neurosurgery, and 14 Microbiology & Immunology, University of Michigan, Ann Arbor, MI, USA 15 16 17 18 19 20 Running title: Novel alphavirus inhibitors 21 22 23 Corresponding author. Mailing address: 3560B MSRB II, 1150 W. Medical Center Drive, Ann 24 Arbor, MI, 48109-5688. Phone: (734) 763-0565. Fax: (734) 615-5534. E-mail: 25 milldavi@umich.edu. 26 27 JVI Accepts, published online ahead of print on 16 July 2014 J. Virol. doi:10.1128/JVI.01671-14 Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Differences in Chemotaxis to Fibronectin in Weakly and Highly Metastatic Tumor Cells

We have examined the chemotactic ability of tumor cell lines with different metastatic potential to plasma fibronectin in Transwell chamber assay. Human renal carcinoma cells with highly metastatic potential, SN12 C‐2, chemotactically migrated to fibronectin (10 μg/ml) about three‐fold more strongly than weakly metastatic SN12 C‐4 cells. Similarly, murine melanoma B16–BL6 cells (highly metastatic) showed higher motility to soluble fibronectin in comparison with weakly metastatic B16–F1 cells. Anti‐VLA‐α3 and β1, antibodies potently blocked the chemotaxis of both highly and weakly metastatic cells (SN12 C‐2 and C‐4) to fibronectin. This implies that the migration of both C‐2 and C‐4 cells to fibronectin is basically mediated by VLA‐3 receptor. In contrast, the anti‐VLA‐as antibody and RGDS peptide significantly inhibited the chemotaxis of SN12 C‐2 cells to fibronectin, but did not affect weakly metastatic SN12 C‐4 cells. These results suggest that the chemotactic ability to fibronectin positively correlates with the metastatic potential in SN12 and B16 cell lines, and that VLA‐5 receptor is concerned in the motility of highly metastatic SN12 C‐2 cells to soluble fibronectin.
NMR Analysis of Base‐Pair Opening Kinetics in DNA

Base pairing in nucleic acids plays a crucial role in their structure and function. Differences in the base‐pair opening and closing kinetics of individual double‐stranded DNA sequences or between chemically modified base pairs provide insight into the recognition of these base pairs by DNA processing enzymes. This unit describes how to quantify the kinetics for localized base pairs by observing changes in the imino proton signals by nuclear magnetic resonance spectroscopy. The determination of all relevant parameters using state‐of‐the art techniques and NMR instrumentation, including cryoprobes, is discussed. © 2014 by John Wiley & Sons, Inc.
Transcriptional regulation: a new dominion for inositol phosphate signaling?

The diverse phosphorylation patterns of the six-carbon inositol ring generates a mesmerizing wealth of inositol phosphates but we have little insight into the precise cellular roles of most members of this family. Therefore, new information on these roles is very welcome. The discovery by two independent groups(1, 2) that the Arg82 transcriptional regulator from Saccharomyces cerevisiae has inositol phosphate kinase activity is intriguing in this respect. One group proposes that these events directly affect the function of a specific, multimeric transcriptional complex. (2) It will be argued here, however, that available data do not entirely support such a direct role for Arg82 in transcription. The potential relevance of these findings to higher organisms will also be discussed.
Editorial: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Guidelines for COPD, Including COVID-19, Climate Change, and Air Pollution

The 2023 Global Initiative for Chronic Obstructive Lung Disease (GOLD) report includes relevant topics from the clinician’s perspective and evidence published on chronic obstructive pulmonary disease (COPD) since GOLD 2017. The World Health Organization (WHO) and GOLD 2023 have developed an updated definition of COPD as, “a heterogeneous lung condition characterized by chronic respiratory symptoms (dyspnea, cough, expectoration, exacerbations) due to abnormalities of the airway (bronchitis, bronchiolitis) and/or alveoli (emphysema) that cause persistent, often progressive, airflow obstruction. ” GOLD 2023 includes recommendations for COPD patients diagnosed with COVID-19 and acknowledges the role of reduced air quality in the etiology and progression of COPD. In May 2023, the GOLD Scientific Committee on Air Pollution and COPD reported that air pollution increasingly contributes to the pathogenesis of COPD. This Editorial aims to introduce the updated GOLD 2023 report in the context of climate change and the aftermath of the COVID-19 pandemic.
Algoritmo para el cálculo del ritmo en una señal de audio digital

In this paper presents an algorithm for extraction of audio rhythm of a digital signal. The rhythm is formed by changes of intensity in the audio data signal. The rhythm marks significant changes in the acoustic signals . Through a procedure of filtering for extraction the envelope of the audio signal, then through a square signal marked the start point and duration of changes on the envelope. The algorithm is tested with a signal of a metronome of 60bps to validate this proposal.
Functional impairment, disability, and quality of life outcome after decompressive hemicraniectomy in malignant middle cerebral artery infarction.

OBJECT Whether decompressive hemicraniectomy is an appropriate treatment for space-occupying middle cerebral artery (MCA) infarction is still a controversial issue. Previous studies are in agreement on a reduction of the mortality rate, but the reported functional outcome was highly variable. The authors sought to determine functional impairment, disability, and health-related quality of life (QOL) outcome in long-term survivors who had undergone this procedure, and tried to identify factors related to functional outcome. METHODS The study included 36 consecutive patients (mean age 58.8 +/- 12.7 years, 20 men and 16 women) who underwent decompressive hemicraniectomy for treatment of malignant MCA infarction (29 on the right and seven on the left side; mean time to surgery 37.8 +/- 20 hours). The survival rate was determined at 6 months: 13.7 +/- 6.7 months after the stroke, a cross-sectional personal investigation of survivors was performed to assess functional impairment, disability, and health-related QOL. Survival rates were 78% at 6 months and 64% at the time of the follow-up investigation; one patient was lost to follow up. Sixteen of 22 long-term survivors lived at home. The median Barthel Index (BI) was 45 (25th and 75th percentile 19 and 71) and the BI correlated negatively with patient age (r = -0.58, p = 0.005). Three patients reached a BI of at least 90. Older age, more severe neurological deficit on admission, and longer duration of intensive care treatment and mechanical ventilation were significantly associated with worse disability (BI < 50). The health-related QOL was considerably impaired in the subscales of mobility, household management, and body care. CONCLUSIONS Decompressive hemicraniectomy improves survival in patients with malignant MCA infarction when compared with earlier reports of conservative treatment alone. Functional outcome and QOL remain markedly impaired, especially among elderly patients and in those with a severe neurological deficit at admission.
Serial Progressive Hierarchical Turbo Codes

Future radio technologies are expected to deliver ever higher bit rates and a wider range of data applications to an increasing number of subscribers. Flexible and high performance unequal error protection techniques are necessary for better application level perceived quality with lower data rates. In this paper, we present a new generalized mechanism for enhanced usage of available spectral resources by embedding unequal error protection in serial turbo codes. The proposed coding scheme allows a progressive and hierarchical encoding of data, considering the prioritizations of information bits. A modified iterative decoding is also proposed. The turbo iterative gain fully benefits all decoding levels, even the least protected data encoded by a single recursive systematic convolutional code. The progressive and hierarchical transmission of extrinsic information from higher levels decoders strongly profit lower priority bits corrections due to inter-data contamination behavior. The prioritized data are hierarchically estimated. The proposed serial progressive hierarchical turbo code has been designed for maximum flexibility and for any number of unequally protected data.
Family History and Five-year Suicide Risk

Family history was examined to determine whether suicide in index patients is associated with suicidal behaviour or mental disorder in their first-degree relatives. Twenty-seven suicides occurred within 5½ years among 955 affectively disordered probands. Among 5042 proband relatives aged 18 years and older, 44 had committed suicide prior to proband entry to the study; however, only one was the relative of a proband suicide. Only two of the relatives who committed suicide were themselves related. As to attempted suicide of relatives, neither the number of attempts nor the severity of attempt was predictive of suicide in probands. Comparison of diagnosis between groups of relatives showed more drug abuse among relatives of proband suicides; this appears to be related to drug abuse among the proband suicides themselves. In contrast to the clustering of suicides within biological families found in other research, these data do not support the use of family history as a clinically useful indicator of suicidal potential in affectively disordered probands.
Ventilation efficiency of street canyons with intersections

When looking at domains with several building densities, the resulting average concentrations caused by traffic when unknown, are often linearised between known building densities. To verify if this assumption is correct, several cases of street canyons with intersections, are simulated using the DALESURBAN model. The traffic is represented by a constant emission line source spanning the entire width of the periodic domain. The building density is increased, by increasing the span wise width of the obstacles, while keeping the obstacle height and stream wise obstacle width constant. The aspect ratio of the street canyons is kept constant for all cases and thereby remains in the skimming flow regime. Four span wise obstacle widths are compared in this study and tested under four wind angles ranging from perpendicular to the street canyon to almost parallel to the street canyon. To test the effects of obstacle placement on the spreading of pollutant, the obstacles are placed in an constant and non-constant pattern. For the constant spreading the stream wise streets are all of equal width, and for the non-constant pattern, a wide street is followed by a small street resulting in an alternating pattern. The resulting mean volume-averaged concentrations for the cases above complemented with, mean retention time, ACH and PCH at roof level of the volume show a linear trend for almost all cases. The exceptions in this linear trend are found at the non-perpendicular wind angles. Where at the two lowest wind angles and the highest building density, the pollutant is recirculated in the domain through the span wise periodic boundaries, resulting in a steep increase in mean volume-averaged concentration and mean retention time. Another exception is there for the wind angle just below the perpendicular one, where a large concentration is contained in the cavity at high building density, which is not present at lower building densities.
Méthode de lutte contre l'Oryctes en replantation de palmier à huile

La replantation d'une vieille palmeraie a pour consequence la proliferation de l'Oryctes car les stipes de palmiers, en se decomposant, deviennent des refuges de predilection pour les larves de cet insecte. Plusieurs essais ont ete mis en place pour etudier l'efficacite de divers traitements insecticides et le role que peut jouer la plante de couverture en tant qu'ecran mecanique. Les simples pulverisations d'insecticides sont sans grand effet. Par contre, les traitements consistant a imbiber les fibres d'insecticides sont tres efficaces. Les traitements a la Dieldrine (reduction des populations de 95 p. 100) donnent de meilleurs resultats que ceux realises avec l'Endosulfan. Le simple effet de la plante de couverture, a condition qu'elle recouvre rapidement les vieux stipes, est egalement interessant (reduction des populations de 85 p. 100). Les traitements, compte tenu de leur prix de revient assez eleve, sont difficilement vulgarisables sur de grandes surfaces. (Resume d'auteur)
Neuroimaging in Patients with Seizures of Probable Frontal Lobe Origin

Twenty‐two patients whose electroclinical ictal characeristics suggested frontal lobe seizure foci were studied. Computed tomography (CT) scans showed abnormalities in only 32% of patients whereas magnetic resonance imaging was informative in 45%. 18FDG‐Positron emission tomography (PET) scanning revealed decreased metabolism in 64% of the group. The areas of hypometabolism were focal, regional, or hemispheric. Focal frontal hypometabolism was significantly correlated with the electroclinical (semiologic) ictal localization. Therefore, FDG‐PET scanning is a sensitive and specific technique for investigating patients with seizures of probable frontal lobe origins.
Total and regional cerebral blood flow during moderate and severe exercise in miniature swine.

To determine the influence of exercise on cerebral blood flow, we ran 14 swine at 3-6 mph and at 0-10% grades on a treadmill for 30 min at moderate and severe levels of exercise. Measuring heart rate, cardiac output, and aortic pressure via implanted probes, we injected 15-mum radiolabeled microspheres via the left atrium before and during exercise. We measured their distribution by gamma spectrometry, determining total cerebral blood flow, regional blood flow, and ratio of flow to gray and white matter. Heart rate, cardiac output, and aortic pressure rose progressively with increasing exercise. Total cerebral flow resembled that reported in humans, i.e., it did not change significantly with exercise. Regional flow distribution also failed to change significantly with exercise. The ratio of gray to white matter flow did not change except to the cerebellum where it rose significantly from resting values at both moderate and severe exercise. Gray matter received more flow than white matter during all three conditions of observation. Cerebral blood flow was remarkably constant during even severe exercise.
Grenzüberschreitende Kreditvergabe: Das Beispiel von Deutschland und Österreich

Daten des ifo Kreditklimas, das zweimal jahrlich im Rahmen des ifo Konjunkturtests erstellt wird, zeigen, dass deutsche KMUs in Gebieten nahe der osterreichischen Grenze uber einen besseren Zugang zu Krediten verfugen als andere Unternehmen. Ohne grenzuberschreitende Kredite ware die Nahe zur Grenze im Hinblick auf den Zugang zu Krediten ein Nachteil. Durch grenzuberschreitende Kredite konnte dieser Nachteil ausgeglichen werden. Die Tatsache, dass die Unternehmen von der Grenznahe profitieren, legt nahe, dass osterreichische Banken uber einen Wettbewerbsvorteil verfugen.
3-D flow imaging using a MHz-rate pulse burst LASER system

Over the past decade significant strides have been made in the development of pulse burst laser systems capable of producing high energy laser pulses at repetition rates in excess of 1 MHz. These unique laser systems are currently being used in experiments across a variety of fields ranging from traditional fluid dynamics to combustion to plasma physics. Described here is the use of one such system for 3-D flow visualization whereby a high-repetition rate laser sheet is scanned through the flow field using a galvanometric scanning mirror and flow images are acquired using a high-speed camera. 3-D images are then reconstructed from the resulting stack of 2-D images. Using existing instrumentation, images with 220 x 220 x 68 pixel resolution can be acquired in 136 microseconds with the primary limitation being the speed and resolution of an available high-speed camera. The strength of the technique is illustrated through 3-D flow visualization experiments conducted in a turbulent jet and a turbulent boundary layer. 3-D smoke visualization images of the near-field of a turbulent jet depict the complex 3-D interaction between ring vortices and streamwise vortices that form in axisymmetric shear layer of the jet. Turbulent boundary layer images show the 3-D nature of large-scale structures present in the outer layer of the boundary layer and lay the ground work for more detailed future experiments.