Miracle-dz/UniFAR-FTUs huggingface dataset:
Fermentation Product of RS3 Inhibited Proliferation and Induced Apoptosis in Colon Cancer Cell HCT-116

Cell free supernatant containing short chain fatty acid (SCFA) resulted from fermentation of resistant starch type three (RS3) by Clostridium butyricum BCC B2571 or Eubacterium rectale DSM 17629 were investigated for their ability to inhibit proliferation and induce apoptosis of human colon cancer cell line HCT-116. HCT-116 was cultured in complete medium and after 50% confluent, incubation was continued for another 48 hours in the absence or presence cell free supernatant containing SCFA mixture at butyrate levels up to 10 mM. The study revealed that the proliferation inhibition effect was higher (>80%) on HCT-116 treated with supernatant of C. butyricum BCC B2571 than that (<70%) of HCT-116 treated with supernatant of E. rectale DSM 17629. The cells were induced to undergo apoptosis by both supernatant. The apoptosis occured through mitochondrial pathway by changing the expression of gene Bcl-2 and Bax, thus incresed the Bax/Bcl-2 ratio by more than 3.5 fold. The protein caspase-3 was increased by more than 250% in the presence of the cell free supernatant.
An efficient 3D point cloud data denoising algorithm for ship block visual measurement

For the 3D point cloud data aquired by laser scanning measurement of ship block, an efficient denoising algorithm based on image and normal vector threshold judgement is proposed. Firstly, large scale noise points are eliminated using global threshold judgement based image, then Kuwahara filter algorithm is used for data smoothing and a denoising algorithm based on normal vector threshold judgement is proposed to eliminate noises point excluding ship manufacture sections. The experiment result demonstrates that not only the proposed denoising algorithm keeps key data points but also avoids bluring point cloud boundary and eliminates noise points effectively.
Profiles of recent autobiographical memory retrieval in semantic dementia, behavioural-variant frontotemporal dementia, and Alzheimer’s disease

Episodic autobiographical memory (ABM) comprises recollection for events that are grounded within a specific spatiotemporal context, and usually accompanied by perceptual and emotional information. The neural substrates mediating ABM retrieval are those harbouring significant pathology in semantic dementia (SD) and behavioural-variant frontotemporal dementia (bvFTD), the most common subtypes of FTD. Relatively little is known, however, regarding the differential patterns of contextual details during episodic ABM retrieval across these dementia syndromes. This study investigated episodic ABM retrieval under free and probed recall conditions from 4 time periods with the aim to identify disease-specific profiles of episodic ABM contextual details. Episodic ABM was measured in 25 SD and 15 bvFTD patients and their performance contrasted to that of 17 Alzheimer’s disease (AD) patients and 19 age-matched controls. Critically, SD patients showed relatively preserved recent ABM in comparison with remote epochs. In contrast, bvFTD and AD patients showed a reduced capacity to recall specific and contextually rich ABMs across all life epochs, in both free and probed recall conditions. Analyses of the recent period (last 12 months) provided evidence for different profiles of contextual episodic details recalled in dementia syndromes. Following probing, SD patients’ recall deficits emanated exclusively from compromised Emotion/Thoughts and Spatiotemporal details. In contrast, bvFTD patients were significantly impaired across all categories of contextual details whereas AD patients showed deficits for Event and Emotion/Thoughts details only. As the largest study of ABM in FTD to date, these findings emphasise the differential impairment of recent ABM contextual details contingent on the underlying disease pathology. In addition, these results point towards the importance of investigating the constituent elements of emotion processing and strategic retrieval processes as potential variables mediating recent episodic ABM retrieval. © 2011 Elsevier Ltd. All rights reserved.
Herbicide transport to surface runoff from a claypan soil: Scaling from plots to fields

Streams and drinking water reservoirs throughout the claypan soil region of Missouri and Illinois are particularly vulnerable to herbicide contamination from surface runoff during spring. This study follows a plot-scale study conducted on claypan soils to quantify and compare edge-of-field herbicide losses from a corn–soybean rotation under mulch tillage and no-tillage systems. The objectives of the present study were to confirm at field scale (34.4 ha [85 ac] and 7.8 ha [19.3 ac]) the plot-scale findings (0.37 ha [0.92 ac]) on the effects of tillage and herbicide incorporation on herbicide transport and to evaluate the applicability of plot-scale exponential models in calculating atrazine and metolachlor concentrations as a function of application rate, runoff volume, and days after application at the field scale. Herbicide transport to surface runoff was studied (1997 to 2001) from two fields with cropping systems similar to those on the plots. Field 1 (F1) was a mulch tillage corn–soybean rotation system with surface-applied herbicides, which are then incorporated. Field 2 (F2) was a no-tillage corn–soybean rotation system with surface-applied herbicides that were not incorporated. During each event, runoff volumes were measured, and water samples were collected and analyzed for atrazine and metolachlor concentrations. The percentages of applied atrazine and metolachlor transported to surface runoff from no-tillage (F2) were 3.2 and 2.0 times those from mulch tillage (F1), respectively. Throughout the study period, 1.0% and 3.2% of total atrazine and 1.0% and 2.0% of total metolachlor applied to F1 and F2 were lost to surface runoff, respectively. Similar to the results from the plot study, the model performed well in calculating field atrazine concentrations from both mulch and no-tillage systems with coefficient of determination ≥ 0.70 and Nash and Sutcliffe efficiency ≥ 0.64. However, model performance in calculating metolachlor concentrations was poor for both tillage systems (Nash and Sutcliffe efficiency < 0.35). When the model was modified to include cumulative temperature instead of days after application, performance in calculating atrazine and metolachlor concentrations was improved, particularly metolachlor concentrations at the field scale. The coefficient of determination and Nash and Sutcliffe efficiency values for metolachlor relative to cumulative temperature and days after application were 0.62 and 0.61 versus 0.41 and −0.13 for F1, and 0.73 and 0.55 versus 0.53 and 0.34 for F2, respectively. Overall, the study confirmed plot-scale results that atrazine concentrations and losses were greater for a no-tillage system than for a mulch-tillage system, in which the herbicide was incorporated. The study also showed that the model developed using plot-scale data was applicable in calculating concentrations at the field scale, particularly for atrazine.
Influence of temperature gradual variation over skin microcirculation responses to thermal stimulation

The study of the mechanisms involved in the local temperature control is a model used to understand vascular pathology, especially when endothelium dysfunction is the issue. This study aims to systematize and to compare the response to local changes in temperature, by studying the influence of the heating rate over the response. Several local heating protocols working at 42 or 44oC were performed in the forearm of healthy, female, non smokers volunteers (n=10). Skin microcirculation was evaluated by Laser Doppler Flowmetry during 30 minutes. A new parameter “nadir/peak” (N/P) was calculated to distinguish the shape of the hyperemic response - biphasic when N/P 1. At 42oC the shape is biphasic, independently of the rate of heating. At 44oC the shape was always monophasic. This suggested that local response to heating is dependent from the rate of heating and probably from the activation of nociceptor fibers.
Optimal generic advertising in an imperfectly competitive food industry with variable proportions

This paper determines the impact of food industry market power on farmers' incentives to promote in a situation where funds for promotion are raised through a per-unit assessment on farm output and food industry technology is characterized by variable proportions. Specifically, building on earlier studies by Azzam [Am. J. Agric. Econ. 80 (1998) 76] and Holloway [Am. J. Agric. Econ. 73 (1991) 979], Muth's [Oxford Econ. Papers 16 (1965) 221] model is extended to consider the farm-level impacts of generic advertising when downstream firms possess oligopoly and/or oligopsony power and advertising expenditure is endogenous at the market level. Applying the model to the US beef industry, we find that for plausible parameter values market power reduces farmers' incentives to promote. However, the disincentive is moderated by factor substitution, and effectively vanishes as the factor substitution elasticity approaches the retail demand elasticity. This suggests that the Dorfman-Steinertheorem, suitably modified to account for factor substitution, suffices to indicate optimal advertising intensity in the US beef sector. © 2003 Elsevier B.V. All rights reserved.
Personal-organisational value conflicts and job satisfaction of internal construction stakeholders

This paper concerns the issue of value conflicts in construction organizations. This research was conducted in the Malaysian construction industry to fill the gap in the knowledge in areas of organizational behaviour in the construction industry in terms of the possible effects of conflicts on the job satisfaction of internal construction stakeholders. The conflicts considered are those rooted in differences between personal and organizational values. This research targeted professional project consultants identified as architects, engineers, and quantity surveyors as the internal construction stakeholders in Malaysia. The personal-organizational values and the level of job satisfaction of the stakeholders were assessed using a questionnaire survey. To achieve the research objective, comparative and hierarchical regression analyses were performed. The results generated by the analyses indicated a high level of value conflicts in the construction organizations which significantly and negatively affected job satisfaction of the internal stakeholders. Therefore this research, through investigating the potential effect of value conflicts on the stakeholders’ job satisfaction, reveals the importance of the interaction between personal and organizational values in construction organizations which contributes to the extant literature of organizational behaviour in construction.
Analysis of Processing Steps for Industrial Large Area n-Type Solar Cells with Screen Printed Aluminum-Alloyed Rear Emitter and Selective FSF

Applying the standard process for p-type solar cells to n-type silicon results in a “PhosTop” solar cell with a screen printed alloyed aluminum emitter on the rear side [1]. This cell concept can be improved by adding a selective FSF and a SiO2/PECVD SiNx stack passivation layer, resulting in a highest confirmed stable efficiency of 19.4 % for 6” n-type Cz-Si solar cells [2]. Besides a very low front SRV, this cell concept also demands for a very high bulk lifetime. We therefore analyze the change of bulk lifetime and conductivity after each high temperature process step in the applied cell process. Furthermore we investigate the current generation from the unprinted wafer edge with no emitter.
Effects of fine-scale oceanographic features on the distribution and movements of harbour porpoises Phocoena phocoena in the Bay of Fundy

We describe an integrative approach to studying the fine-scale distribution of harbour porpoises Phocoena phocoena in the Bay of Fundy, using satellite telemetry, line transect surveys and remote sensing techniques. Analysis of satellite telemetry data from 6 porpoises (5 male, 1 female) revealed that over the course of a month individuals ranged across large areas (7738 to 11 289 km 2 ) but concentrated their movements in small focal regions (August mean = 294 km 2 , September mean = 252 km 2 ), often proximate to islands, headlands, or restricted channels. Line transect surveys (n = 25 flood tide, n = 20 ebb tide) in the focal region of 2 tagged animals revealed that relative porpoise density (animals km -2 ) was significantly greater during flood (9.59) than ebb tide phases (1.79). Hydro-acoustic prey surveys revealed aggregations of prey along localized fronts in this region. Remote sensing images indicated the presence of an island wake in the focal region during flood tides, providing an ecological context for our observations of high densities of porpoises. Remote sensing revealed the existence of a headland wake in the focal region of another porpoise near Cam- pobello Island. These results support the hypothesis that regions of enhanced relative vorticity, like island and headland wakes, aggregate prey and represent important foraging habitat for harbour porpoises in the Bay of Fundy.
Design Science Research in Action - Anatomy of Success Critical Activities for Rigor and Relevance

Design Science Research (DSR) has reached a significant impact on scholar’s research work around the globe in the information systems domain. DSR is an important IS research paradigm for creating descriptive and prescriptive knowledge concerning the artificial construction of today’s reality in the interrelation between the social and the technological sub-system. Various prior research has decisively defined and structured DSR in order to derive rigorously relevant contributions in terms of frameworks and methodologies. This paper contributes to this discourse from a research in action point of view by investigating critical activities within the design science phases and when passing from one to the next DSR cycle. For that purpose we elaborate critical DSR activities and demonstrate their effective execution along four DSR in action examples to provide guidance and best practices for design science projects seeking for rigor and relevance.
The Use of Subepithelial Connective Tissue Graft Technique to the Treatment of Class I Miller Recession in Lower Tooth with Abrasion: Case Report

Gingival recession can cause aesthetic problems, discomfort for cervical dentin hypersensitivity and can be treated by connective tissue grafts. This case report used subepithelial connective tissue graft to treatment class I Miller recession in premolar lower with abrasion. The premolar were treated by scaling and root planing chemical modification with 24% ethylenediaminetetraacetic acid (EDTA), bur shaped reconteur of abrasion lesion and subepithelial connective tissue graft combined with coronal flap. The results provide excellent root coverage, improve the root hypersensitivity and abrasion lesion. Although the longevity of this successful treatment depends on the diagnosis and removal of the causative agent, as well as the patient's cooperation in maintained of oral hygiene.
Tax Morale and Fiscal Policy

ax morale has received a growing attention in academics as well as in public life. The relevance of tax morale for fiscal policy cannot be neglected as tax morale can help to explain the level of tax compliance or tax evasion. This paper gives an overview of tax morale with a special focus on Switzerland. We highlight the magnitude and the de-terminants of tax morale that have been isolated so far and discuss directions for future research in this area. In particular, we concentrate on fiscal policy implications.
Photons without borders: quantifying light pollution transfer between territories

The light pollution levels experienced at any given site generally depend on a wide number of artificial light sources distributed throughout the surrounding territory. Since photons can travel long distances before being scattered by the atmosphere, any effective proposal for reducing local light pollution levels needs an accurate assessment of the relative weight of all intervening light sources, including those located tens or even hundreds of km away. In this paper we describe several ways of quantifying and visualizing these relative weights. Particular emphasis is made on the aggregate contribution of the municipalities, which are -in many regions of the world- the administrative bodies primarily responsible for the planning and maintenance of public outdoor lighting systems
A variable domain approach to reconfiguration of WSI processor arrays

A novel reconfiguration algorithm for WSI (wafer scale integration) processor arrays using the concept of a variable domain is discussed. Variable domain is decided based on a fault distribution. The algorithm utilizes fault distribution information in the global assignment phase as well as in the local assignment phase. The concept of variable domain used in the algorithm overcomes the weakness of fixed domain approaches in the presence of clustered faulty cells. The number of faulty cells to be tolerated need not be predefined; thus a logical array maximizes the dimension from a given faulty physical array. <<ETX>>
Anti-cancer effect of ethylacetate fraction from Orostachys japonicus on HT-29 human colon cancer cells by induction of apoptosis through caspase-dependent signaling pathway

Objective: To investigate the anti-colon cancer effects of ethylacetate fraction from Orostachys japonicus (O. japonicus) on HT-29 cancer cells. Methods: The viability of HT-29 cells was assayed by the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) method. Apoptosis induction and cell cycle inhibition were confirmed by fluorescein isothiocyanate and propidium iodide staining using flow cytometry. Morphological changes in the nucleus were observed, using a fluorescence microscope with 4′,6-diamidino-2-phenylindole (DAPI) nuclear staining. The expression levels of the upstream and downstream proteins involved in the anti-cancer mechanism were confirmed by Western blotting. Results: After treating HT-29 cells with different concentrations of ethylacetate fraction from O. japonicus, the viability of cells decreased in a concentration-dependent manner, while apoptosis induction and apoptotic body formation increased. Cell cycle analysis showed that the arrest occurred at the sub-G1 and S phase. Among the upstream and downstream proteins involved in anti-cancer activity, the level of B cell lymphoma-2 decreased, and the bcl-2-associated x protein increased. The level of pro-caspase-3, pro-caspase-8, and pro-caspase-9 decreased, while the level of cleaved-caspase-3, cleaved-caspase-8, and cleaved-caspase-9 increased. Moreover, the phosphorylation, that is, activation of extracellular signal regulated kinase 1/2, Jun-N-terminal kinase, and p38 increased. Conclusions: Combining the above results, it is thought that the survival of HT-29 cells is suppressed by ethylacetate fraction from O. japonicus through mitochondrial regulation-induced caspase cascade activation, induction of apoptosis and cell cycle arrest.
2354-0082 Design and Development of Animal Recognition Application Using Gamification and Sattolo Shuffle Algorithm on Android Platform Case Study : Kebun Binatang Ragunan

Information and communication technology has been developed rapidly and affected various aspects such as propagation of information and marketing strategy of tourist attraction. Kebun Binatang Ragunan is one of tourist attraction in Indonesia. Aside from recreation area, Kebun Binatang Ragunan can be a place to learn animals. However, learning animals itself tends to be less attractive and less interactive. Therefore, an application was developed as one of animal learning media to increase tourist motivation. The application developed in form of quiz game by using gamification like achievement to increase their motivation in animals learning and using Sattolo Shuffle algorithm in order to make quiz more varied. After testing, the application is known affect the Behavioral Intention to Use level around 76.96% and Immersion level around 82.43% in giving motivation and attracting tourist attention to use the application. Sattolo Shuffle algorithm successfully applied in application to produce a unique sequence of each randomized quiz. Keywords—Achievement, Animal Recognition, Gamification, Quiz Game, Sattolo Shuffle.
Transgenic crops: Priorities and strategies for India †

Development of plant transformation technology is impacting crop improvement options in unprecedented ways. While the new technology promises greater efficiency and precision to plant breeding, to be effective, its application needs to be carefully planned on a case-by-case basis. Transgenic crops, in this context, have the additional dimension of biosafety consideration and hence their development and deployment demands greater care. Here we discuss the various factors that need to be considered while prioritizing crops and traits for transgenic improvement and show how intelligent use of some of the strategies can help alleviate biosafety concerns associated with commercialization of transgenics.
Growing grassroots innovations: Exploring the role of community-based social movements for sustainable energy transitions

The challenges of sustainable development (and climate change and peak oil in particular) demand system-wide transformations in socio-technical systems of provision. An academic literature around co-evolutionary innovation for sustainability has recently emerged to attempt to understand the dynamics and directions of such socio-technical transformations and social change, which are termed ‘sustainability transitions’. This literature has previously focused on market-based technological innovations. Here we apply it to a new context of social movements and social innovation, and examine the role of civil society-based social movements in a transition to a low-carbon sustainable economy in the UK. We present new empirical research from a study of the UK’s Transition Movement (a ‘grassroots innovation’) and assess its attempts to grow and diffuse beyond the niche. Applying strategic niche management theory to this civil society context delivers theoretically-informed practical recommendations for this social movement to diffuse beyond its niche: to foster deeper engagement with resourceful regime actors; to manage expectations more realistically by delivering tangible opportunities for action and participation; and to embrace a communitybased, action-oriented model of social learning (in preference to a cognitive theory of behaviour change). Furthermore, our study indicates areas where theory can be refined to better explain the experience of grassroots innovations and social movements, namely through a fuller appreciation of internal niche processes, and integration with theories of social movements and social practices. 1 Centre for Social and Economic Research on the Global Environment (CSERGE), School of Environmental Sciences, University of East Anglia, Norwich, NR4 7TJ, UK g.seyfang@uea.ac. uk 2 Tyndall Centre for Climate Change Research School of Environmental Sciences, University of East Anglia, Norwich, NR4 7TJ, UK alex.haxeltine@uea.ac. uk