Miracle-dz/UniFAR-FTUs huggingface dataset:
THE BLOW-UP RATE FOR A SEMILINEAR PARABOLIC EQUATION WITH A NONLINEAR BOUNDARY CONDITION

by a standard approximationprocedure (see [2] for the details). The solution of (1.1) only exists for a ﬁniteperiod of time (in this case ubecomes unbounded in ﬁnite time and we say that itblows up) or it is deﬁned for all positive t(in this case we call it a global solution). In our problem one has a nonlinear term at the boundary and a reaction termin the equation. If λ>0, these two terms compete and the blow up phenomenonoccurs if and only if p<2q−1 or p= 2q−1 with λ
Augmented virtual stiffness rendering of a cable-driven SEA for human-robot interaction

Human-robot interaction U+0028 HRI U+0029 is fundamental for human-centered robotics, and has been attracting intensive research for more than a decade. The series elastic actuator U+0028 SEA U+0029 provides inherent compliance, safety and further benefits for HRI, but the introduced elastic element also brings control difficulties. In this paper, we address the stiffness rendering problem for a cable-driven SEA system, to achieve either low stiffness for good transparency or high stiffness bigger than the physical spring constant, and to assess the rendering accuracy with quantified metrics. By taking a velocity-sourced model of the motor, a cascaded velocity-torque-impedance control structure is established. To achieve high fidelity torque control, the 2-DOF U+0028 degree of freedom U+0029 stabilizing control method together with a compensator has been used to handle the competing requirements on tracking performance, noise and disturbance rejection, and energy optimization in the cable-driven SEA system. The conventional passivity requirement for HRI usually leads to a conservative design of the impedance controller, and the rendered stiffness cannot go higher than the physical spring constant. By adding a phase-lead compensator into the impedance controller, the stiffness rendering capability was augmented with guaranteed relaxed passivity. Extensive simulations and experiments have been performed, and the virtual stiffness has been rendered in the extended range of 0.1 to 2.0 times of the physical spring constant with guaranteed relaxed passivity for physical humanrobot interaction below 5 Hz. Quantified metrics also verified good rendering accuracy.
Voluntary Internet Disclosures by Listed Companies in the Arabian Gulf

The purpose of this paper is to examine the determinants and characteristics of voluntary internet disclosures by listed companies in Bahrain and Qatar. This paper uses archival data from listed companies in the Bahrain Bourse and Qatar Stock Exchange. Binary Logistic Regression analysis is used to examine the determinants of internet financial reporting. Mann-Whitney test is used to examine the differences in disclosure characteristics between the two countries. The results of this study reveal that firm size and audit type are the major influencing factors that impact internet financial reporting. The results reveal that a number of disclosure characteristics that differ significantly between the two countries. The paper provides insights into corporate internet disclosure in the GCC countries that will benefit all stakeholders with an interest in corporate reporting in this important region of the world.
Adipocyte Fatty Acid–Binding Protein Suppresses Cardiomyocyte Contraction: A New Link Between Obesity and Heart Disease

Rationale: Adipocyte fatty acid–binding protein (FABP4) is a member of the intracellular lipid-binding protein family and is predominantly expressed in adipose tissue. Emerging evidence suggests that FABP4 plays a role in some aspects of the metabolic syndrome including the development of type 2 diabetes and atherosclerosis. We have recently reported that secretory products from human adipocytes directly and acutely depressed cardiac contractile function. Objective: The purpose of this study was to identify this adipocyte-derived cardiodepressant factor. Methods and Results: Through mass spectrometry and immunoblotting, we have identified this cardiodepressant factor as FABP4. FABP4 represents 1.8% to 8.1% of total protein secreted by adipocytes in extracellular medium. FABP4 acutely depressed shortening amplitude as well as intracellular systolic peak Ca2+ in a dose-dependent manner in isolated rat cardiomyocytes. Heart-specific FABP isoform (FABP3) revealed a similar cardiodepressant effect. The N-terminal amino acids 1 to 20 of FABP4 could be identified as the most effective cardiodepressive domain. We could exclude any effect of FABP4 on action potential duration and L-type Ca2+ current, suggesting a reduced excitation-contraction gain caused by FABP4 as the main inhibitory mechanism. Conclusion: We conclude that the release of FABP4 from adipocytes may be involved in the development of cardiac contractile dysfunction of obese subjects.
You look blocky, is everything alright? Inﬂuence of video distortions on facial expression recognition & quality

The ability to read expressions on human faces is hard-wired in the human brain, as a very powerful tool to sample non-verbal information about the emotional disposition of other people. Nowadays, more and more face-to-face interactions are happening over multimedia systems, including video conferencing, watching movies and interacting with virtual characters. Some of these systems usually rely on compression and other data reduction mechanisms to cope with limited transmission speeds. This paper evaluates the impact of typical video distortions, such as compression, spatial and temporal down-scaling, on the ability of human subjects to recognize facial expressions. We use a realistic face simulator to generate four basic facial expressions, which we distort under typical scenarios, and measure both the ability of participants to recognize the facial expressions and the overall perceived quality. Our results show that the scene composition and the expressions have a signiﬁcant impact on perception, and show some evidence on the relation be-tween recognition rate and perceived quality.
Kisspeptin as a therapeutic target in reproduction

ABSTRACT Introduction: Kisspeptins are a family of neuropeptides whose identification has become one of the biggest discoveries in reproductive endocrinology during the past decade. Kisspeptins act upstream of GnRH as high-level mediators of the reproductive axis. Areas covered: The authors performed a search of all publications on kisspeptin since its discovery in 1996. A full appraisal of the expanding literature concerning kisspeptin is beyond the scope of this review. This article therefore aims to cover the principle human studies outlining kisspeptin action in human physiology and to discuss the key findings, describing kisspeptin’s potential as a therapeutic target in human reproduction. Expert opinion: The identification of the kisspeptin signaling pathway has greatly advanced the study of reproductive endocrinology. Building on a large body of animal data, a growing number of human studies have shown that exogenous kisspeptin can stimulate physiological gonadotropin responses in both healthy subjects and those with disorders of reproduction. There is an increasing appreciation that kisspeptin may act as a signal transmitter between metabolic status and reproductive function. Future work is likely to involve investigation of novel kisspeptin analogs and further exploration of role of neurokinin B and dynorphin on the kisspeptin-GnRH axis.
Quality of life and the cancer experience: the state-of-the-knowledge.

PURPOSE/OBJECTIVES To address the state-of-the-knowledge concerning quality of life (QOL) issues and the cancer experience from theoretical, research, clinical, and educational perspectives. DATA SOURCES Published books and articles and a panel of experienced QOL experts who convened at the Oncology Nursing Society's State-of-the-knowledge Conference on Quality of Life in February 1995. DATA SYNTHESIS Despite the evolution and support of QOL in oncology nursing practice, education, and research, there remains gaps in theory, research, and practice related to QOL. This article explores these gaps in knowledge and recommends future directions for QOL theory, research, education, and practice. CONCLUSIONS Further conceptual work and resolution of QOL methodologic issues to guide clinical practice and education are warranted. The impact of cultural variables and precancer life experiences on patients' perceptions of QOL also must be addressed. NURSING IMPLICATIONS Oncology nurse clinicians, educators, and researchers must continue to work collaboratively to enhance the knowledge base regarding QOL and to improve the nursing care provided to individuals with cancer.
Spotlight on Varietal Thiols and Precursors in Grapes and Wines

Wine is an amazingly complex natural product that requires dedicated scientists to resolve many of its mysteries. Traditional synthetic organic chemistry and modern analytical techniques are powerful tools at the disposal of wine chemists who tackle the complexities of wine in order to improve scientific understanding and provide practical solutions to industry. Part of this quest for knowledge relates to maintaining or improving wine quality, which underpins consumer acceptance and links to the competitiveness of wineries in a global market. Wine aroma is an important aspect of wine quality and garners much attention from researchers. Grape-derived aroma compounds are one area of particular importance owing to their distinctiveness and ability to impart ‘varietal aromas’ to wines. Varietal thiols imparting tropical and citrus notes that are characteristic of wines such as Sauvignon Blanc have emerged, along with their grape-derived precursors, as an area of interest over the past two decades. These compounds have also caught our attention and we have made some important contributions to this field, including identifying new precursors, developing novel analytical methods, and conducting studies that provide unique insights into the biochemical transformations occurring in grape berries and juice, and during fermentation.
A research on the establishment of an information security environment for the finance industry

Due to the development of information technology, relevant business information of enterprise and government authority is stored in the computer by means of digital method. In addition, it relies on computer and network to maintain it operation. Due to the characteristics of network, person with intention to commit crime can conduct criminal behavior by linking with the network at any time and at any place. If there is no appropriate control on the information asset, information can be easily altered or deleted and even important information may be disclosed thereby generating serious loss. As the business of the finance industry includes the personal and transaction information of customer, therefore the requirement on information security has to be more stringent than other industry. Moreover, for the consideration on information security, generally this is conducted based on the angle of technology, but other factors are ignored. In fact, information security has three aspects including technology, management and policy. This thesis will provide suggestion on the overall information security protection on the information environment of the finance industry. Furthermore, study is conducted on the information regulation/industry standard and flow planning that can be used to provide an overall information security solution plan that is safe and efficient.
Excellent airport customer service meets successful branding strategy

Excellent customer service is the synergy created when an airport’s ability to exceed its customers’ needs and expectations consistently matches its customers’ perception that their needs and expectations are well met.This is particularly challenging in the airport environment where, although many are responsible for the delivery of services, the customer and other stakeholders often hold the airport operator accountable for the level of service provided airport-wide. If airport management takes a strategic and holistic approach to customer service and airport branding, customer satisfaction with the airport experience can be significantly improved and airport net revenues can be tracked to show a direct relationship with increased customer satisfaction.
Hemin utilization is related to virulence of Streptococcus pneumoniae

Streptococcus pneumoniae is a causative agent for bacterial pneumonia, otitis media, meningitis, and bacteremia. Mechanisms for acquisition of iron by this organism under low-iron conditions were investigated. Siderophore production was not detected by either chemical or biological methods. Its utilization of iron-containing compounds found in human hosts was tested. Both hemin and hemoglobin supported the full growth of S. pneumoniae in a culture lacking other iron sources, while lactoferrin and transferrin failed to do so. A mutant defective in hemin utilization was isolated and was less virulent than wild-type S. pneumoniae in experimental animals.
Stuyvesant Town - Peter Cooper Village: America's Largest Foreclosure

In July 2010, William Ackman, the founder of Pershing Square, is considering a potential new opportunity: the acquisition of the distressed Stuyvesant Town and Peter Cooper Village ("ST /PCV") complex. The property had recently been abandoned by its owners and had come under the control of CW Capital, the special service for the vast amount of debt that was in default. Any investment in a distressed property could be very risky and might require the company to seek protection in the bankruptcy courts. While the bankruptcy process was not new for Ackman, it could add significant complexity and unknown outcomes. Ackman must consider whether this is a worthwhile investment, given the ambiguous valuation and significant public scrutiny of any investment deal.Learning Objective:This case is intended to introduce students to the risks and opportunities available in large-scale investment deals, particularly when bankruptcy and foreclosure issues are involved. Students will analyze the risks, determine the valuation, and evaluate the investment thesis proposed by Ackman.
Successful Combination Treatment of a Patient with Progressive Juvenile Localized Scleroderma (Morphea) Using Imatinib, Corticosteroids, and Methotrexate

We report a case of progressive juvenile localized scleroderma (JLS or morphea) treated with a combination of imatinib, corticosteroids, and methotrexate. This therapy halted the progressive skin thickening and the hand and finger joint deformity in the early stages of the disease. We conclude that imatinib used in addition to standard treatment with systemic corticosteroids and methotrexate may be of therapeutic benefit for individuals with JLS.
Antioxidant Properties of Whole Grain Cereals

Cereals have a long history of use by humans. Cereals and cereal products are staple foods, and are important source of energy, carbohydrate, protein, fi bre, vitamins (E, B) and minerals (Zn, Mg, Fe) in both developed and developing countries. The health aspects of whole grain cereals have long been known, but the antioxidant profi le of whole grains has only recently been introduced to the antioxidant research community where mostly fruits and vegetables are in focus. In vitro experiments confi rm antioxidant richness of whole grains and their specific fractions, but further in vivo investigations are needed to confi rm the activity. Great variety of whole grain antioxidants suggest that regular consumption of whole grain cereals may have a signifi cant role in slowing down degenerative processes and prevention of chronic diseases.
Operations excellence : smart solutions for business success

Introduction- Operations Excellence PART I Introduction - What is Successful Product Development? Changing Business Models and their Impact on Product Development Innovate to Win Global Development made Successful Success Factors and Levers for Best Practise in Innovation Management Smart Engineering Processes 'Made in Japan' PART II Introduction - Strategic Trends and Challenges for Purchasing Key Trends in Purchasing Best Practises and Impact on Purchasing Strategy Purchasing Empowerment- The Way to Achieve World Class Purchasing PART III Introduction - Manufacturing in a Global Context Organizations Drive Strategy and Performance: Insights from Two Successful Lead Buying Models How Companies can Optimize their Global Manufacturing Footprint Leveraging Manufacturing Excellence in Global Production From Maintenance to Quality Control PART IV Introduction - Supply Chain Management - More than just Logistics Global Supply Chain Management - A Success Factor for Global Players Complexity Management- The Starting Point for Improving Performance Working Capital Excellence - How Companies Can Tap Hidden Cash Reserves in the Supply Chain Supply Chain Organization - A Key Enabler for Successful Supply Chain Management
Knowledge Puzzle: A Tool for Constructivist Learning from Hypertext

This paper presents Knowledge Puzzle, a tool for knowledge construction from the Web. Its main contribution to Web-based learning is the adaptation of information structure on the Web to cope with the interlinked knowledge structure in the learner’s mind. Self-directed learners will be able to adapt the path of instruction on the Web to their way of thinking, regardless of how the Web content is delivered. The way to achieve that is to provide the learner with a metacognitive tool that enables him to bring his knowledge to the surface and visualize what he has in mind. Once we get the learner’s viewpoint externalized, it will be converted to a hypermedia layer that will be laid over the Web pages visited by the learner. The attached layer adapts the views of Web pages to the learner’sinformation needs by associating information pieces that are not already linked in hyperspace and attaching the learner’s notes to the page content.
Marketing capabilities, innovation and firm performance

The importance of marketing capabilities and innovation is widely acknowledged in strategic marketing literature. Yet, extant research has examined the importance of these strategic factors independently in providing firm’s economic benefits. In this dissertation, I propose three standalone yet interwoven essays, in answering questions regarding the interplay of these two strategic factors and their sources. Essay one proposes the integration of both marketing capabilities and innovation in exploring how marketing capabilities enhance firm’s ability to profit from innovation. Essays two and three examine the sources and consequences of marketing and innovative capabilities. The second essay proposes CEO’s personality trait of self-monitoring as a key driver of a firm’s innovative capabilities. Essay three investigates how CEO’s managerial ties aid in enhancing the impact of marketing and innovation capabilities on profit growth over time. Overall, through these three essays I attempt to demonstrate the importance of marketing and innovation capabilities and provide a fresh perspective in examining the sources and outcomes of these capabilities.
Internet of Things Research on Semantic Interoperability to Address Manufacturing Challenges

This paper gives an overview on interoperability challenges and in particular for semantic interoperability addressing manufacturing within the Internet of things research cluster (IERC). In the Internet of Things area, business and manufacturing aspects have not been clearly taken into account yet but there is an important need to include requirement and challenges from this area as there are a lot of common issues and additional values that current experience and deployments in manufacturing can be relevant. More specifically it is discussed semantic discovery and interoperability issues related to intangible assets and to products-services manufacturing ecosystems. The IoT challenges in semantic interoperability presented in this paper are also defined in a EU position paper to be published in 2014.
WIN 55,212-2 decreases the spatial spread of neocortical excitation in vitro

The ‘intrinsic optical signal’ was used to monitor neuronal network excitability. The cannabinoid receptor type 1 agonist WIN 55,212-2 reduced the intensity and the spatial spread of the intrinsic optical signal and prolonged its kinetics in the rat neocortex in vitro. These effects were antagonized by the cannabinoid receptor antagonist SR141716A. Thus, our results suggest that neocortical network activity is modulated via the activation of cannabinoid receptors. The decrease of neocortical network excitability in the present study is probably due to a decreased excitability of glutamatergic neurons.
DNA sequence motifs conserved in endocrine promoters are essential for Pax4 expression

The paired box transcription factor Pax4 is required for maturation of insulin‐producing β‐ and somatostatin secreting δ‐cells in the murine pancreas. It starts to be expressed in pancreatic precursors and later is restricted to β‐ and δ‐cells to finally be switched off after birth. A 0.9‐kb genomic DNA fragment has been shown to mediate the Pax4 expression pattern. Transcription factors Pdx1 and NeuroD bind to this fragment at A2‐ and E1‐sequence motifs. In this study, we downscale the size of this fragment to 409 bp. Another genomic fragment of 254 bp is still able to mediate the specificity, but not the strength of Pax4 expression. Deletion of the A2 and E1 elements results in loss or weakening of reporter gene expression. Because A2 and E1 elements are conserved in numerous pancreatic promoters, they might play a general role in regulating endocrine gene expression. Developmental Dynamics 228:617–622, 2003. © 2003 Wiley‐Liss, Inc.
Endocrine potency of wastewater: Contents of endocrine disrupting chemicals and effects measured by in vivo and in vitro assays

Industrial and municipal effluents are important sources of endocrine disrupting compounds (EDCs) discharged into the aquatic environment. This study investigated the endocrine potency of wastewater and the cleaning efficiency of two typical urban Danish sewage treatment plants (STPs), using chemical analysis and a battery of bioassays. Influent samples, collected at the first STP grate, and effluent samples, collected after the sewage treatment, were extracted using solid phase extraction. Extracts were analyzed for the content of a range of industrial chemicals with endocrine disrupting properties: phthalate metabolites, parabens, industrial phenols, ultraviolet screens, and natural and synthetic steroid estrogens. The endocrine disrupting bioactivity and toxicity of the extracts were analyzed in cell culture assay for the potency to affect the function of the estrogen, androgen, aryl hydrocarbon, and thyroid receptors as well as the steroid hormone synthesis. The early‐life stage (ELS) development was tested in a marine copepod. The concentrations of all analyzed chemicals were reduced in effluents compared with influents, and for some to below the detection limit. Influent as well as effluent samples from both STPs were found to interact with all four receptors and to interfere with the steroid hormone synthesis showing the presence of measured EDCs. Both influent samples and one of the effluent samples inhibited the development of the copepod Acartia tonsa. In conclusion, the presence of EDCs was reduced in the STPs but not eliminated, as verified by the applied bioassays that all responded to the extracts of effluent samples. Our data suggest that the wastewater treatment processes are not efficient enough to prevent contamination of environmental surface waters. Environ. Toxicol. Chem. 2011;30:413–426. © 2010 SETAC