Miracle-dz/UniFAR-FTUs huggingface dataset:
ParaDox: Eliminating Voltage Margins via Heterogeneous Fault Tolerance

Providing reliability is becoming a challenge for chip manufacturers, faced with simultaneously trying to improve miniaturization, performance and energy efficiency. This leads to very large margins on voltage and frequency, designed to avoid errors even in the worst case, along with significant hardware expenditure on eliminating voltage spikes and other forms of transient error, causing considerable inefficiency in power consumption and performance. We flip traditional ideas about reliability and performance around, by exploring the use of error resilience for power and performance gains. ParaMedic is a recent architecture that provides a solution for reliability with low overheads via automatic hardware error recovery. It works by splitting up checking onto many small cores in a heterogeneous multicore system with hardware logging support. However, its design is based on the idea that errors are exceptional. We transform ParaMedic into ParaDox, which shows high performance in both error-intensive and scarce-error scenarios, thus allowing correct execution even when undervolted and overclocked. Evaluation within error-intensive simulation environments confirms the error resilience of ParaDox and the low associated recovery cost. We estimate that compared to a non-resilient system with margins, ParaDox can reduce energy-delay product by 15% through undervolting, while completely recovering from any induced errors.
The impact of peer assisted learning on mentors’ academic life and communication skill in medical faculty: A systematic review

Peer assisted learning (PAL) was initiated to support the first-year students. In medical faculty, first-year students often find starting new academic life challenging. The impact from the peer mentors’ aspect is not widely explore. The aim of this study was to review studies that reported the impact of PAL programs on peer mentors in medical faculty, particularly on their academic life and communication skill. The DOAJ, PubMed Central, SciELO, and Science Direct databases advanced search used to conduct a systematic literature searching. Systematic search was performed according to preferred reporting items for systematic reviews and meta-analysis (PRISMA) checklist recommendations. Five studies were included. All of the reviewed studies shown the impact of PAL programs on mentors’ academic life. Three studies have shown both the impact of PAL programs on mentors on their academic life and communication skill. Studies in this review have shown positive impacts on mentors’ academic life and communication skill. Good communication skills, empathy, leadership and teaching skills will promote individual abilities and skills as a doctor, be it as a practitioner, or as an educator.
The Tools of Management

At the same time that workers' rights are generally declining in the United States (US), workplace computing systems gather more data about workers and their activities than ever before. The rise of large scale labor analytics raises questions about how and whether workers could use such data to advocate for their own goals. Here, we analyze the historical development of workplace technology design methods in CSCW to show how mid-20th century labor responses to scientific management can inform directions in contemporary digital labor advocacy. First, we demonstrate how specific methodological tendencies from industrial scientific management were adapted to work in CSCW, and then subsequently altered in crowd work and social computing research to more closely resemble industrial approaches. Next, we show how three tactics used by labor unions to strategically engage with industrial scientific management in the mid-20th century can inform data-driven worker advocacy in platform-mediated work. Finally, we discuss how this history shapes our understanding of worker participation and the implications of using worker data for contemporary advocacy goals.
Requirements for Biosimilar Authorization: A Legal and Comparative Perspective – FDA Versus EMA

CURRENT SCIENCE, VOL. 120, NO. 1, 10 JANUARY 2021 56 Alfonso Noguera Peña is in the Pharmacy Military Centre of Defence. Logistic Base San Pedro, Highway M-609 Miraflores, km 34, E-28770, Colmenar Viejo (Madrid), Spain; Universidad Complutense de Madrid, History of Pharmacy and Pharmaceutical Legislation, Department of Galenic Pharmacy and Food Technology. Ramon y Cajal Square s/n, E28040, Madrid (Madrid), Spain; Carlos del Castillo Rodríguez is in the Universidad Complutense de Madrid, History of Pharmacy and Pharmaceutical Legislation, Department of Galenic Pharmacy and Food Technology. Ramon y Cajal Square s/n, E-28040, Madrid (Madrid), Spain. *For correspondence. (e-mail: alfnogue@ucm.es) Requirements for biosimilar authorization: a legal and comparative perspective – FDA versus EMA
Analysis of the Possible Reasons for the Decrease in the Effectiveness of Genetic Markers in Sports Search

The study of the processes occurring in the body under the influence of intense physical exertion, in order to increase the efficiency of the training process and the performance of athletes, is an important issue in the physiology of sports. It is known that the strength, speed, endurance and other morpho-functional features of a person are genetically determined. Therefore, the actual direction of research is the establishment of a spectrum of polymorphic genetic variants of genes associated with a predisposition to perform physical activities of varying intensity, as well as their phenotypic manifestation in professional activity. However, despite the active search for genetic markers in sports with the use of modern high-tech technologies, it has not yet been possible to identify universal genes associated strictly with certain physical qualities. Perhaps, there is a number of factors that affect gene activity. Therefore, the purpose of the literature review is to search and analyze possible causes that can influence the activity of genes, for example, the most studied angiotensin-converting enzyme (ACE) gene associated with the development of specialized physical qualities in athletes.
Role-Playing Paper-Reading Seminars

The paper-reading seminar is a common format for advanced topics courses in Computer Science graduate programs. Over the span of the course, students read a series of academic papers published on a particular topic (for example, Deep Learning with Limited Labeled Data ). For cutting-edge topics close to the frontier of research, standard texts may not exist and academic papers are the primary available references. Some niche areas may not be mature enough to develop a lecture-based course curriculum around. Complementary to course topic-speciﬁc learning objectives, paper-reading seminars aim to achieve learning outcomes related to the soft skills of technical reading, public presentation
Obesity does not Impair Ambulatory Cardiovascular and Autonomic Responses Post-exercise

Abstract This study aimed to assess whether obesity and/or maximal exercise can change 24 h cardiac autonomic modulation and blood pressure in young men. Thirty-nine men (n: 20; 21.9±1.8 kg·m−2, and n: 19; 32.9±2.4 kg·m−2) were randomly assigned to perform a control (non-exercise) and an experimental day exercise (after maximal incremental test). Cardiac autonomic modulation was evaluated through frequency domain heart rate variability (HRV). Obesity did not impair the ambulatory HRV (p>0.05), however higher diastolic blood pressure during asleep time (p=0.02; group main effect) was observed. The 24 h and awake heart rate was higher on the experimental day (p<0.05; day main effect), regardless of obesity. Hypotension on the experimental day, compared to control day, was observed (p<0.05). Obesity indicators were significantly correlated with heart rate during asleep time (Rho=0.34 to 0.36) and with ambulatory blood pressure(r/Rho=0.32 to 0.53). Furthermore, the HRV threshold workload was significantly correlated with ambulatory heart rate (r/Rho=− 0.38 to−0.52). Finally, ambulatory HRV in obese young men was preserved; however, diastolic blood pressure was increased during asleep time. Maximal exercise caused heart rate increase and 24h hypotension, with decreased cardiac autonomic modulation in the first hour, regardless of obesity.
Stochastic properties of partial-discharge phenomena

The author presents a bibliography and survey of the literature concerned with theory and measurement of the stochastic behavior of pulsating partial-discharge (PD) phenomena that can occur when insulation is subjected to electrical stress. The types of PD phenomena considered include AC and DC generated electron avalanches, pulsating positive and negative corona in gases, and PD that occur in liquid media and in the presence of solid dielectric surfaces. The basic physical mechanisms of discharge initiation, growth, and memory propagation that determine the probability distributions for pulse occurrence times and pulse amplitudes are discussed. Consideration is also given to special problems associated with the measurement and interpretation of data on the various statistical properties of PD phenomena. >
Biorenewable blends of polyamide-11 and polylactide

Polyamide-11(PA11) is melt blended with polylactide (PLA) using 0.00 to 0.10 wt% titanium isopropoxide catalyst to investigate potential compatibilizing reactions. Blend properties are characterized by differential scanning calorimetry (DSC), thermogravimetric analysis, dynamic mechanical thermal analysis, and tensile and impact testing. DSC shows two separate glass transition temperatures indicating only partial miscibility. Base etching to remove PLA domains followed by field emission scanning electron microscopy confirms the two phase nature of the blends. Storage and tensile moduli of the blends increase monotonically with increasing PLA content. Interchange reactions during reactive mixing were investigated by 13 degrees C-NMR spectroscopy but the analysis shows little evidence of interchange reactions. This is true irrespective of catalyst level and mixing time over the temperature range from 185 degrees C to 225 degrees C. At the upper end of the temperature range investigated, significant degradation is observed. The combined results indicate that degradation reactions dominate over compatibilizing interchain transreactions. (C) 2013 Society of Plastics Engineers
Nitrate Removal in Stream Riparian Zones

This review considers the role of stream riparian zones in regulating the transport of nitrate (NO 3 - ) in groundwater flow from uplands to streams. The current consensus is that most riparian zones effectively remove NO 3 - from subsurface water. However, research has not focused on the relationship between hydrology and chemistry within the context of the riparian zone hydrogeologic setting. Most riparian zones that remove NO 3 - occur in landscapes with impermeable layers near the ground surface. In this setting, small amounts of groundwater follow shallow horizontal flow paths that increase water residence time and contact with vegetation roots and organic-rich riparian soils. Limited research suggests that riparian zones have less effect on NO 3 - transport in hydrogeologic settings where groundwater has little interaction with vegetation and sediments because flow occurs mainly across the surface, or at depth beneath the riparian zone before discharging to the stream. Considerable uncertainty surrounds the relative importance of vegetation uptake and microbial denitrification in NO 3 - removal from subsurface water in riparian zones. Plant NO 3 - uptake requires the presence of the root zone below the water table. Information is lacking on the vertical distribution and seasonal dynamics of fine root biomass in relation to water table fluctuations. High denitrification rates have been reported in 0 to 10 cm surface soils of riparian zones in the USA, France, and New Zealand. However, rapid NO 3 - removal from groundwater also occurs in riparian locations where the water table is always >0.5 m below the surface. Denitrification at depth within the saturated zone has been studied to a limited extent and has been found not to occur at some sites. An interdisciplinary approach in which patterns of NO 3 - depletion and the role of NO 3 - removal processes are related to groundwater flow paths is needed to provide a better understanding of NO 3 - regulation in riparian zones.
Afatinib Exerts Immunomodulatory Effects by Targeting the Pyrimidine Biosynthesis Enzyme CAD

This study elucidates a mechanism of afatinib-mediated immunosuppression and provides new insights into treatment timing for combined targeted therapy and immunotherapy. Current clinical trials of combined EGFR-tyrosine kinase inhibitors (TKI) and immune checkpoint blockade (ICB) therapies show no additional effect. This raises questions regarding whether EGFR-TKIs attenuate ICB-enhanced CD8+ T lymphocyte function. Here we show that the EGFR-TKI afatinib suppresses CD8+ T lymphocyte proliferation, and we identify CAD, a key enzyme of de novo pyrimidine biosynthesis, to be a novel afatinib target. Afatinib reduced tumor-infiltrating lymphocyte numbers in Lewis lung carcinoma (LLC)–bearing mice. Early afatinib treatment inhibited CD8+ T lymphocyte proliferation in patients with non–small cell lung cancer, but their proliferation unexpectedly rebounded following long-term treatment. This suggests a transient immunomodulatory effect of afatinib on CD8+ T lymphocytes. Sequential treatment of afatinib with anti-PD1 immunotherapy substantially enhanced therapeutic efficacy in MC38 and LLC-bearing mice, while simultaneous combination therapy showed only marginal improvement over each single treatment. These results suggest that afatinib can suppress CD8+ T lymphocyte proliferation by targeting CAD, proposing a timing window for combined therapy that may prevent the dampening of ICB efficacy by EGFR-TKIs. Significance: This study elucidates a mechanism of afatinib-mediated immunosuppression and provides new insights into treatment timing for combined targeted therapy and immunotherapy. Graphical Abstract: http://cancerres.aacrjournals. org/content/canres/81/12/3270/F1.large. jpg. Graphical Abstract
Ammonia concentration in farrowing pens with permanent limited range of motion for lactating sows

Dubeova M. , Galik R. , Mihina S. , Sima T. , 2013. Ammonia concentration in farrowing pens with permanent 3 ) and greenhouse gases. Pig production is globally responsible for about 15% of ammonia emissions. Th e aims of this paper were the comparison of the ammonia concentrations in the farrowing pens with permanent limited range of motion between the zones of lactating sows and piglets and the impact of the day hour on ammonia concentration in this place. Photoacoustic infrared measuring devices INNOVA were used. Th e average values of NH 3 concentration ranged from 0.787738 ppm (0.547478 mg/m 3 ) to 0.818091 ppm (0.568573 mg/m 3 ). Th e minimum concentration of NH 3 was measured in the second lactating sows zone (0.262535 ppm, 0.182462 mg/m 3 ) and the maximum concentration was measured in the piglets zone (1.61803 ppm, 1.124531 mg/m 3 ). Values measured met the requirements of the Decree No. 230/1998 of the Ministry of Agriculture and Rural Development of the Slovak Republic which allows the maximum concentration of NH 3 in the pig building 20 ppm (13.9 mg/m 3 ). Th ere were no diff erences between the concentrations of the greenhouse gases (GHGes) in the zones of lactating sows and piglets.
Critical evaluation of stability constants of phosphonic acids (IUPAC Technical Report)

Abstract Available experimental data on stability constants of proton and metal complexes for 10 phosphonic acids [methylphosphonic acid, 1-hydroxyethane-1,1-diylbisphosphonic acid, dichloromethylenebisphosphonic acid, amino-methanephosphonic acid, N-(phosphonomethyl)glycine, imino-N,N-bis(methylenephosphonic acid), N-methylamino-N,N-bis(methylenephosphonic acid), nitrilotris(methylenephosphonic acid), 1,2-diaminoethane-N,N,N´,N´-tetrakis-(methylenephosphonic acid), and diethylenetriamine-N,N,N´,N´´,N´´-pentakis-(methylenephosphonic acid)], published in 19501997, have been critically evaluated. For the latter phosphonate, all the data are rejected, as well as protonation constants [HL]/[H][L] for three other ligands. Higher-quality data are selected and presented as "Recommended" and "Provisional".
Anodic oxidation of 3,5-dihalogenotyrosines as a model reaction for the biogenesis of the cavernicolins, metabolites of the verongid sponge Aplysina cavernicola

Anodic oxidation of 3,5-dibromo-4-methoxyphenylalanine methyl ester 3, led to cavernicolin [3,3a,7,7a-tetrahydro-3a-hydroxyindole-2,6(1H)-dione] model compounds although equilibration to all four possible stereoisomers 4α, 4β, 5α and 5β was a special characteristic of the model compounds only. This may constitute a new model for the biogenesis of the cavernicolins as an alternative to a spirolactone route from oxidation of amino-protected tyrosines. Chemical oxidation gave poor results.
FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and Dendrite Development

Abstract Elaboration of neuronal processes is an early step in neuronal development. Guidance cues must work closely with intracellular trafficking pathways to direct expanding axons and dendrites to their target neurons during the formation of neuronal networks. However, how such coordination is achieved remains incompletely understood. Here, we characterize an interaction between fasciculation and elongation protein zeta 1 (FEZ1), an adapter involved in synaptic protein transport, and collapsin response mediator protein (CRMP)1, a protein that functions in growth cone guidance, at neuronal growth cones. We show that similar to CRMP1 loss-of-function mutants, FEZ1 deficiency in rat hippocampal neurons causes growth cone collapse and impairs axonal development. Strikingly, FEZ1-deficient neurons also exhibited a reduction in dendritic complexity stronger than that observed in CRMP1-deficient neurons, suggesting that the former could partake in additional developmental signaling pathways. Supporting this, FEZ1 colocalizes with VAMP2 in developing hippocampal neurons and forms a separate complex with deleted in colorectal cancer (DCC) and Syntaxin-1 (Stx1), components of the Netrin-1 signaling pathway that are also involved in regulating axon and dendrite development. Significantly, developing axons and dendrites of FEZ1-deficient neurons fail to respond to Netrin-1 or Netrin-1 and Sema3A treatment, respectively. Taken together, these findings highlight the importance of FEZ1 as a common effector to integrate guidance signaling pathways with intracellular trafficking to mediate axo-dendrite development during neuronal network formation.
Joint development recovery on resumption of embryonic movement following paralysis

Fetal activity in utero is a normal part of pregnancy and reduced or absent movement can lead to long-term skeletal defects such as Fetal Akinesia Deformation Sequence (FADS), joint dysplasia and arthrogryposis. A variety of animal models with decreased or absent embryonic movements show a consistent set of developmental defects providing insight into the aetiology of congenital skeletal abnormalities. At developing joints defects include reduced joint interzones with frequent fusion of cartilaginous skeletal rudiments across the joint. At the spine defects include shortening and a spectrum of curvature deformations. An important question, with relevance to possible therapeutic interventions for human conditions, is the capacity for recovery with resumption of movement following short term immobilisation. Here we use the well-established chick model to compare the effects of sustained immobilisation from embryonic day (E) 4-10 to two different recovery scenarios: (i) natural recovery from E6 until E10 and (ii) the addition of hyperactive movement stimulation during the recovery period. We demonstrate partial recovery of movement and partial recovery of joint development under both recovery conditions, but no improvement in spine defects. The joints examined (elbow, hip and knee) showed better recovery in hindlimb than forelimb, with hyperactive mobility leading to greater recovery in the knee and hip. The hip joint showed the best recovery with improved rudiment separation, tissue organisation and commencement of cavitation. This work demonstrates that movement post paralysis can partially-recover specific aspects of joint development which could inform therapeutic approaches to ameliorate the effects of human fetal immobility. Summary Statement The study reveals that embryonic movement post paralysis can partially-recover specific aspects of joint development, which could inform therapeutic approaches to ameliorate the effects of restricted fetal movement in utero.
Tri- and tetradentate copper complexes: a comparative study on homogeneous and heterogeneous catalysis over oxidation reactions

Catalytic liquid phase oxidation of benzene, phenol, styrene and cyclohexene was carried out using Schiff-base copper(II) complexes of ligands 4-(2-amino-ethylimino)-pent-2-en-2-ol (HL1) and (4-[2-(3-hydroxy-1-methyl-but-2-enylideneamino)-ethylimino]-pent-2-en-2-ol (H2L2) in homogenous and heterogeneous media. Treatment of Cu-Y-zeolite with ligand solutions led to insertion of the flexible ligands into zeolite super-cages and in situ formation of encapsulated copper(II) complexes inside the zeolite cavities. The encapsulated complexes [Cu(L2)]-Y and [CuCl(L1)]-Y were characterized using FT-IR, UV-vis, Raman spectrometry, BET, XRD and thermal analysis techniques, substantiating the formation of intrazeolitic copper complexes without loss in the crystallinity for the zeolite framework structure. Catalytic activities of the encapsulated complexes and their “neat” analogues were investigated for the oxidation of benzene, phenol, styrene and cyclohexene using H2O2 as an oxidant. Conversion efficiencies were optimized by varying reaction parameters, i.e. temperature, oxidant concentration, catalyst amounts and solvent nature and volume. In all oxidation reactions, the neat complexes exhibited higher conversion efficiency than the encapsulated complexes at shorter reaction times under optimum reaction conditions. Although the zeolite-encapsulated complexes required longer reaction times to reach maximum conversion, they were beneficial towards enhancing the selectivity and TOF values as compared to the neat analogues. Furthermore, the heterogeneous catalytic system can be recovered and reused without activity loss. The possible reaction pathway for phenol oxidation catalysed by these complexes was investigated by UV-visible spectroscopy and electrochemical methods.