Miracle-dz/UniFAR-FTUs huggingface dataset:
Contribution of PET Studies in Diagnosis of Corticobasal Degeneration

Five patients with clinical features of corticobasal degeneration (CBD) were studied with PET imaging. The main clinical findings included a unilateral extrapyramidal motor disorder, without significant response to levodopa, as well as clumsiness, dysarthria, apraxia and a clear asymmetry of neurological signs. PET studies with 18F-labeled 2-deoxy-2-fluoro-D-glucose disclosed mainly a significant hypometabolism in the thalamus and motor cortex controlateral to the more affected limbs. Additional relationships between individual clinical signs and PET data were also found. We concluded that PET findings supported the clinical diagnosis of CBD, although the specific pattern related to this condition needs to be more precisely defined. Further studies are especially needed to correlate clinical data and PET results with pathological examination.
A Circularly Polarized Broadband Printed Array With a Bud-Shape Feedline Network

This letter develops a printed two-element parallel array consisted of dual rhombic loops and a reflecting plate for broadband, high-gain, and circular polarization (CP) operation. An improved mixed feedline network of bud-shape junction is suggested for the parallel antenna array design. The bud-shape junction not only converts the coplanar stripline to the microstrip line, but also expands the impedance-match bandwidth. The dual parasitic rhombic loops are applied to broaden the CP operation bandwidth. The antenna array is simulated and fabricated with good agreement obtained between the simulation and experimental results. The fabricated prototype shows that the bandwidth of AR <; 3 dB, S11 <; -10 dB, and gain > 12 dB is 18.1%, 18.8%, and 12.1%, respectively. A 2 × 4-array structure is also presented using this bud-shape junction, and it is easy to be expanded to large arrays for high-gain applications.
Gene expression in single cells of Bacillus subtilis: evidence that a threshold mechanism controls the initiation of sporulation

Early during endospore formation in the bacterium Bacillus subtilis, two distinct cell types are formed. The initiation of this developmental pathway requires several physiological conditions (e.g., nutrient deprivation) and is controlled by the Spo0A transcription factor. We have found that in a culture of sporulating cells, there are two subpopulations, one that has initiated the developmental program and activated the expression of early developmental genes and one in which early developmental gene expression remains uninduced. We measured the expression of developmental (spo) genes in single cells of B. subtilis by using spo-lacZ fusions. Cells containing a spo-lacZ fusion were stained with a dye that fluoresces upon hydrolysis by beta-galactosidase, and the fluorescence in individual cells was measured with a flow cytometer. For Spo+ cells, we found that the proportion of the population expressing early developmental genes correlates well with the fraction of the population that eventually produces spores. In addition, mutations that cause a decrease in the amount of activated (phosphorylated) Spo0A transcription factor cause a decrease in the size of the subpopulation expressing early developmental genes that are directly activated by Spo0A approximately P. Again, the size of the subpopulation correlates well with the fraction of cells that produce spores. These results indicate that a threshold level of activated Spo0A (Spo0A approximately P) or of a component of the phosphorylation pathway must accumulate to induce sporulation gene expression and that most of the cells that are able to induce the expression of early genes that are directly activated by Spo0A approximately P go on to produce mature spores. (ABSTRACT TRUNCATED AT 250 WORDS)
Not all affirmative action rewards merit.

with the broad range of problems generated in a technologically advanced democracy? Crosby et al. (2003) responded to this question by suggesting that psychology is capable of offering the valid moral choice and the correct public policy. Their solution suffers from four liabilities. First, they failed to demonstrate how the science of psychology can logically yield such a conclusion in preference to the moral principle of equal rights for individuals. Second, they misrepresented the function of a science in a democratic society. It is not to identify the correct public policy but instead to provide unbiased information so that voters and their representatives can make educated decisions in preference to uninformed choices. Third, they have corrupted the reputation of psychology by conflating the roles of scientists and political advocacy. The contributions of psychologists who abide by such a distinction will be perceived with suspicion or ignored. Fourth, by strongly advocating preferential treatment, they may discourage support for more politically acceptable and more effective policies of assisting the disadvantaged (e.g., early educational interventions). Finally, it should be noted that two different conceptions of science are being offered. For Crosby et al. (2003), science has to meet the combined standards of truth and social function. Seeking the latter will inevitably contaminate the former. History suggests that the dual-function conception of science characterizes totalitarian regimes, whereas the view that science searches for empirical truth is consistent with an open society. Unless the profession of psychology frees itself from political agendas, its value to a democracy will be badly compromised if not destroyed.
RF microcoil design for practical NMR of mass-limited samples.

This paper addresses practical issues involved in obtaining high resolution 1H NMR spectra from samples containing less than 10 nmol. Solenoidal microcoils have been constructed to: (a) assess the effects of magnetic susceptibility mismatches at 500 MHz, (b) increase the concentration sensitivity of microcoil probes, (c) incorporate a lock channel for 2D experiments and long 1D acquisitions, and (d) assess the total amount of the sample required (with respect to the coil length) to avoid line broadening due to edge effects. Compared to previously published microcoil results, sample volumes have been increased by a factor of 20 with a concomitant decrease in the required concentration (5-20 mM). Perfluorocarbon susceptibility matching remained effective at 500 MHz, allowing acquisition of high resolution NMR spectra. A lock channel has also been successfully incorporated in microcoil probes. The limits of detection for sucrose with a 10 min acquisition time were found to be 17.8 and 34.1 pmol for the single and double resonance coils, respectively. A sample length of approximately 10 times than that of the coil was required to avoid magnetic susceptibility artifacts.
Clamp Techniques in Paediatrics: What Have We Learned?

The marked increase in conditions associated with insulin resistance in youth, including obesity, polycystic ovary syndrome, type 2 diabetes mellitus etc., has prompted the need to assess insulin sensitivity in this age group. Even though insulin resistance plays an important role in disorders of glucose metabolism and other pathological conditions, both insulin sensitivity and insulin secretion should be determined for a comprehensive evaluation of glucose homeostasis disorders. Insulin sensitivity and secretion are intricately coupled with a delicate feedback mechanism governing their relationship. This article will delineate our paediatric experience with the clamp technique, the hyperinsulinaemic-euglycaemic clamp in assessing in vivo insulin sensitivity, and the hyperglycaemic clamp in assessing insulin secretion.
Action of bleomycin on DNA and RNA.

Bleomycin, exclusively yet not necessarily, affects thymidine-containing compounds such as DNA and polydeoxyribonucleotides by releasing free thymine and leaving aldehyde functions. Bleomycin action can be enhanced by adding reducing as well as oxidizing agents. Several radical scavangers were without influence. The guanidino moiety in the bleomycin could be traced as a functionally essential group. Molecular morphology and base sequence of the DNA strongly influence bleomycin activity. High bleomycin concentrations, besides modifying DNA into oligothyminic or athyminic nucleic acids, cause strand scissions. Possible reaction mechanisms are discussed.
Richter's syndrome with two different B‐cell clones

The diagnoses of chronic lymphocytic leukemia (CLL) in prolymphocytic transformation, and diffuse large cell lymphoma (DLC), were made simultaneously in a 71‐year‐old man. The DLC showed mu lambda surface immunoglobulin. The CLL in a lymph node and in the peripheral blood showed mu kappa. Immunoglobulin gene DNA analysis confirmed the presence of different rearrangements in the heavy and light chain genes of the CLL and DLC. Other cases reported of Richter's syndrome are discussed, and it is concluded that there may be two types of Richter's syndrome, those arising from transformation of a single clone, and those occurring from expansion of two morphologically and immunologically distinct clones, as, it is believed, is the case in this patient.
盘点2007 The good,the bad,and the ugly

当历史的车轮行将跨过2007年这一页时,我们甚至很难对其作出准确的定义。 传奇、丑闻、离别、回归、希望,争议,这一年拥有令人咋舌的丰富内容,却又缺乏里程碑似的结论,只揭示了模糊的无限可能。 正如一百个观众眼中就有一百个哈姆雷特,既然我们无法提供一个准确的结论,倒不如罗列出几个现象,记录这个动荡的时代。
MicroRNA signatures differentiate melanoma subtypes

Melanoma is an aggressive cancer that is highly resistance to therapies once metastasized. We studied microRNA (miRNA) expression in clinical melanoma subtypes and evaluated different miRNA signatures in the background of gain of function somatic and inherited mutations associated with melanoma. Total RNA from 42 patient derived primary melanoma cell lines and three independent normal primary melanocyte cell cultures was evaluated by miRNA array. MiRNA expression was then analyzed comparing subtypes and additional clinicopathologic criteria including somatic mutations. The prevalence and association of an inherited variant in a miRNA binding site in the 3’UTR of the KRAS oncogene, referred to as the KRAS-variant, was also evaluated. We show that seven miRNAs, miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04). In addition, we discovered that the KRAS-variant was enriched in non-acral melanoma (25%), and that miR-137 under expression was significantly associated with melanomas with the KRAS-variant. Our findings indicate that miRNAs are differentially expressed in melanoma subtypes and that their misregulation can be impacted by inherited gene variants, supporting the hypothesis that miRNA misregulation reflects biological differences in melanoma.
Intermittent obstruction of left ventricular assist device due to prolapsing papillary muscle.

Common causes of left ventricular assist device (LVAD) inflow cannula obstruction include hypovolemia, thrombus and cannula impingement against the interventricular septum or the ventricular free wall. [1] Obstruction due to the left ventricular papillary muscles is less commonly considered[2] and, to the best of our knowledge, there are only two reports of this: one diagnosed with echocardiography[3] and the other found at autopsy. [4]
Word Order and the Principle of "Early Immediate Constituents" (EIC)

EIC (the principle of “Early Immediate Constituents”) seeks to explain word order variation at the phrase level in performance and processes of grammaticalisation on the basis of human information processing. It is embedded in functionally oriented linguistic modelling and typological argumentation. By quantification and empirical testing of EIC driven hypotheses, the principle proves rather plausible although some questions are still to be answered and integration into a wider linguistic model will have to be accomplished.
Comparación de métodos moleculares útiles en la detección rápida de Mycobacterium tuberculosis Multirresistente (MTB-MRD)

Objetivo: evaluar y comparar dos metodosmoleculares rapidos utilizables en la deteccionde pacientes con MTB-MRD. Material y Metodos:realizamos un estudio experimental para comparar la eficiencia de los metodos: "rifoligotyping" e Inno-LIPA, utilizando como "gold standard" el metodo de las proporciones multiples. La poblacion de estudio fueron 41 aislamientos de pacientes con tuberculosisMRD y 43 de pacientes con tuberculosis farmacosensible. Se amplifico por PCR un fragmentodel gen rpob utilizando un par de iniciadoresdiferentes para cada metodo y posteriormentese detecto mediante hibridizacion reversa en membranas y tiras, la presencia de mutaciones que confieren resistencia a rifampicina. Se calculo la sensibilidad, la especificidad, el valor predictivo de MRD (VPMRD) y el valor predictivo de farmaco sensibilidad (VPFS) para cada una de las pruebas y se compararon enterminos de eficiencia.
Synergic and Competitive Inhibition Effect BetweenTwo Kinds of Arylamines in the Formation of Hemoglobin Adduct In Vitro

Abstract This article presents our work with HPLC-UV to determine hemoglobin adducts produced by adduction reaction among 4-aminobiphenyl (4-ABP) or/and 2-naphthylamine (2-NA) and human hemoglobin in vitro. The results showed that HPLC-UV could efficiently be used to detect aromatic amine-hemoglobin adduct. Two kinds of optimized linear models modified from the traditional dose-response model were screened out. The models implied that synergic effect exists between the two kinds of arylamines adducted with hemoglobin and competitive inhibition effect occurs in the formation of hemoglobin adduct when the two kinds of arylamines are present in the blood synchronously. The results indicate that models for dose-response relationship should take the effects of the other toxicants into consideration in the mixed pollutant system.
Servo state feedback based on Coefficient Diagram Method in magnetic levitation system with feedback linearization

The challenge design of servo state feedback controller is how to determine the parameter value of integral gain and state feedback gains. This paper proposes CDM (Coefficient Diagram Method) to determine gains of servo state feedback controller. We apply this controller in the nonlinear plant, magnetic levitation system, and firstly transform the system to be linear using feedback linearization. CDM is one of the polynomial methods in a control system that based on the equivalent time constant and stability index. The simulation observes the performance of the system with various stability index besides the CDM standard parameter and also compares the CDM with another method i. e. LQR. The simulation shows that the CDM standard parameter can give a good performance of the system so that can avoid the effort of trial and error.
Estudo e implementação de algoritmos inteligentes para detecção e classificação de falhas na medição de gás natural

Esta dissertacao apresenta o estudo e implementacao de algoritmos inteligentes para o monitoramento da medicao de sensores envolvidos em processos de transferencia de custodia de gas natural. Para a criacao destes algoritmos sao investigadas arquiteturas de Redes Neurais Artificiais devido a caracteristicas particulares, tais como: aprendizado, adaptacao e predicao. Um preditor e implementado com a finalidade de reproduzir o comportamento dinâmico da saida de um sensor de interesse, de tal forma que sua saida seja comparada a saida real do sensor. Uma rede recorrente e utilizada para este fim, em virtude de sua capacidade em lidar com informacao dinâmica. A saida real do sensor e a saida estimada do preditor formam a base para a criacao das estrategias de deteccao e identificacao de possiveis falhas. Duas arquiteturas de redes neurais competitivas sao investigadas e suas potencialidades sao utilizadas para classificar tipos diferentes de falhas. O algoritmo de predicao e as estrategias de deteccao e classificacao de falhas, bem como os resultados obtidos, serao apresentados
The value of pool factoring in capital-constrained supply chain

As a new supply chain financing tool, pool factoring is used to mitigate the increasingly serious imbalance between capital supply and demand. In order to explore the significance of pool factoring, we establish a two-echelon financial supply chain game model with a factor and a supplier, considering capital constraint, factor's decision objective is capital return maximization, then we obtain the equilibrium solution. We find that pool factoring provides incentives for participants and broaden the cooperation space of the financial and real economy; However, our study also shows pool factoring can't change the rule that factor dominate in financing under capital constraint.
Information theoretic performance bounds for noisy compressive sensing

Compressive sensing provides a new approach to data acquisition and storage. In this paper, we derive some information theory bounds on the performance of noisy compressive sensing to calculate the data rate with particular distortion, which has significant meaning in data storage technique. We analyze the rate distortion performance of noisy compressive sensing under Mean Squared distortion and Hamming distortion, and give more accurate results. Besides, mathematical lower bounds of rate distortion function and theoretical minimal useful bit rates are provided for these two distortion for the first time. We also give a theoretical upper bound of the Mean Squared distortion of compressive sensing process. The relationships of bit rate per dimension R(D)/N and M, N, and M/N are given and plotted in this paper, and both theoretical analysis and numerical results show that compressive sensing uses less number of bits to represent the same information compared to conventional information acquisition and reconstruction techniques.
Eyebrow Surgery: The Supraciliary Craniotomy: Technical Note

OBJECTIVE: Many approaches have been recommended for the surgical treatment of anterior and middle cranial fossa lesions. The frontobasal approach and its many modifications have been proposed and developed for such situated lesions. An alternative approach is the frontolateral craniotomy through a supraciliary skin incision. METHODS: This minimally invasive technique, a 2.5 × 3.0 cm craniotomy, just above the eyebrow through a supraciliary incision, is a simple but elegant modification of the traditional approach to the anterior cranial fossa. RESULTS: A step-by-step description of the approach is offered in this report to facilitate a clear understanding of the lesions treatable with this minimally invasive technique. CONCLUSION: The supraciliary frontolateral keyhole craniotomy is a minimally invasive cosmetic approach that provides excellent exposure to a variety of intracranial lesions. This approach cannot be used for all intracranial pathologies, but is recommended for many anterior and middle cranial fossa lesions.
Consistent Scene Editing by Progressive Difference Images

Even though much research was dedicated to the acceleration of consistent, progressive light transport simulations, the computation of fully converged images is still very time‐consuming. This is problematic, as for the practical use in production pipelines, the rapid editing of lighting effects is important. While previous approaches restart the simulation with every scene manipulation, we make use of the coherence between frames before and after a modification in order to accelerate convergence of the context that remained similar. This is especially beneficial if a scene is edited that has already been converging for a long time, because much of the previous result can be reused, e.g., sharp caustics cast or received by the unedited scene parts. In its essence, our method performs the scene modification stochastically by predicting and accounting for the difference image. In addition, we employ two heuristics to handle cases in which stochastic removal is likely to lead to strong noise. Typical scene interactions can be broken down into object adding and removal, material substitution, camera movement and light editing, which we all examine in a number of test scenes both qualitatively and quantitatively. As we focus on caustics, we chose stochastic progressive photon mapping as the underlying light transport algorithm. Further, we show preliminary results of bidirectional path tracing and vertex connection and merging.
Molecular Cytogenetic Analysis of B-CLL Patients with Aggressive Disease

Abstract We tested a set of commercially available probes to determine the feasibility and accuracy of FISH in the detection of abnormalities in 13 patients with Chronic Lymphocytic Leukemia (CLL) with a particular aggressive clinical disease. We utilized three different probes for the 13q12-14 region, one for the centromeric region of chromosome 12, one for the P53 gene at 17p13.1 and one for 3′-5′ IGH at 14q32, covering the entire region of IGH, thus potentially allowing to detect more rearrangements. Conventional cytogenetic study showed a normal karyotype in 8/13 patients. FISH was able to detect chromosomal abnormalities in 10/13 pts (85%): +12 in 4 pts (38%); del 13q in 4 (38%); del 17p in 3 (35%); del of 5′-IGH in 1 (15%). In conclusion FISH confirmed its ability to improve the detection of cytogenetic abnormalities especially in patients with an aggressive disease.
[Venous stents].

The continuous development of stents in the past 20 years has facilitated the widespread use of stents in the arterial and venous system. The idea of stents is tightly related to the name of Charles Dotter, the inventor of percutaneous transluminal angioplasty (PTA). Stents can be placed for various causes of obstruction, both benign and malignant, throughout the venous system either, primarily, in combination with fibrinolysis, or as adjunct to PTA or surgical intervention. Stent placement is a minimal invasive method associated with a low complication rate and a high clinical success mainly due to differences of the properties and of the pressure between veins and arteries. Special cases of veinous stents are hemodialysis shunts, where patency rates are not improved but critical situations can be managed, and transjugular intrahepatic porto-systemic shunts (TIPS), which have high rates of complication and restenosis requiring frequent reinterventions.
Results of longterm hospital based cytological screening in asymptomatic women

Routine cytological screening has been carried out in 27,062 asymptomatic women attending Gynaec and Family Planning O.P.D. of Queen Mary's Hospital, Lucknow, India (April 1971–December 2004). Incidence of squamous intraepithelial lesion (SIL) was found to be 5.9% in the series, while cervical malignancy was seen in 0.6% of cases. The study highlighted the immense utility of cytological screening in minimizing the incidence of carcinoma cervix in the segment of the urban population screened, as the incidence dropped down to 0.5% in the second half from 1.1% noticed in the first half of the screening period. The study also emphasized the utility of clinically downstaging the cervical cancer as 7,316 women showing clinical lesions of cervix were found to harbor SIL in 15.3% and carcinoma cervix in 1.3% of cases as against the incidence of 2.5% for SIL and 0.6% for frank cancer in women with normal cervix.
Ellipse et coordination en grammaire logique

Le formalisme decrit dans ce papier s'inspire de la theorie chomskyenne des transformations generalisees Merge et Move. Il s'agit d'un merge chaque fois qu'on reunit deux nœuds sous la meme racine et il s'agit d'un move, plus ou moins deguise, chaque fois que l'on procede au dechargement d'une hypothese. L'introduction de l'exponentielle " ! " d'apres les travaux de la logique lineaire (Girard, 1987) permet d'envisager des deplacements simultanes fondamentaux dans les processus d'ellipse et de coordination. En ce sens, c'est introduire une part de parallelisme dans le calcul de la structure linguistique.