Miracle-dz/UniFAR-FTUs huggingface dataset:
Micropillar type three-axis force sensor for measurement of cellular force

This paper reports a three-axis force sensor that can measure cellular forces in real time with high sensitivity. The sensor features a photoresist micropillar fabricated on a flexible cross-shaped Si structure. The three dimensional forces acting on the micropillar can be detected from the resistance changes of three piezoresistors designed on the Si structure. Due to the flexibility of the Si beams, a sensing resolution on the order of several nN was obtained for both shear forces and normal force. Moreover, in our sensor design, the sensing beams are covered by a photoresist cap that prevents cells from attaching to the piezoresistors while it maintains the space for the beams and the micropillar to deform. We confirmed that our sensor can detect the normal and shear forces acting on the micropillar caused by an osteosarcoma cell during its detachment from the surrounding walls.
Nature of Science and Scientific Inquiry as Contexts for the Learning of Science and Achievement of Scientific Literacy

Although the reasons for concern about quality differ from nation to nation, the primary rallying point for science education reform is the perceived level of scientific literacy among a nationâs populace. The essential nature of scientific literacy is that which influences studentsâ decisions about personal and societal problems. Beyond this, however, educators work to influence studentsâ ability to view science through a more holistic lens. Examining the philosophy, history, and sociology of science itself has the potential to engender perceptions of science, in the broader context, that can impact the lens through which students view the world. The integration of explicit, reflective instruction about nature of science (NOS) and scientific inquiry (SI) in traditional science content is addressed as a means through which the development of scientific literacy is fostered.
Information Technology to Support Electronic Meetings

As managers spend more of their time in meetings, the study of information technology to support meetings becomes increasingly important. Several unique systems to support meetings electronically have been developed in industry and universities. The PLEXSYS systems at the University of Arizona have been operational since 1985 and are now being implemented in industrial sites. This article proposes and defines a new term for information technology systems that support group meetings: electronic meeting systems (EMS). EMSs are more than group decision support systems (GDSS): they support more tasks than just decision making; they focus on communication. They move beyond the GDSS decision room where groups must meet at the same time in the same place, to meetings that can be conducted across time ands pace. The article then presents a model fo th EMS concept, which has three components: group process and outcomes; methods; and environment. Each of these component is explained in turn, and the implications derived form their study to date are discussed. Finally, the implementation of information technology for meeting support and its use in corporate settings will be addressed, as it has implications for productivity, meeting size, group member participat9ion, and the role of the IS department.
Function evolution and forecasting for product innovation

The evolution of product function is the result of demand evolution or system evolution, which is governed by certain laws and is predictable. The composition of function structure and function classification are proposed to lay the foundation for function evolution. The stages division and laws of function evolution are proposed to point out the direction for function design, and the approaches of function are proposed to give the concrete method of function design. The forecasting zones of function evolution are proposed to provide a practicable space. The contradiction analysis is to make evaluation of function evolution, then TRIZ tools and CAI software can help designer to solve the contradiction and generate principle solutions. Integrated above contents, the product innovation process model based on function evolution and forecasting is proposed, which provides a systematic approach to product innovation from functional design angle. A innovative design example of pill dispersing machine demonstrates the proposed method is feasible.
Effect of low doses of cosyntropin on serum cortisol concentrations in clinically normal dogs.

OBJECTIVE To determine the lowest of 5 doses of cosyntropin (1.0, 0.5, 0.1, 0.05, or 0.01 microg/kg) administered IV that stimulates maximal cortisol secretion in clinically normal dogs. ANIMALS 10 clinically normal dogs. PROCEDURES 5 dose-response experiments were performed in each of the dogs. Each dog received 5 doses of cosyntropin (1.0, 0.5, 0.1, 0.05, and 0.01 microg/kg) IV in random order (2-week interval between each dose). Serum samples for determination of cortisol concentrations were obtained before (baseline) and at 10, 20, 30, 40, 50, 60, 120, and 240 minutes after cosyntropin administration. RESULTS Compared with baseline values, mean serum cortisol concentration in the study dogs increased significantly after administration of each of the 5 cosyntropin doses. Mean peak serum cortisol concentration was significantly lower after administration of 0.01, 0.05, and 0.1 microg of cosyntropin/kg, compared with findings after administration of 0.5 and 1.0 microg of cosyntropin/kg. After administration of 0.5 and 1.0 microg of cosyntropin/kg, mean peak serum cortisol concentration did not differ significantly; higher doses of cosyntropin resulted in more sustained increases in serum cortisol concentration, and peak response developed after a longer interval. CONCLUSIONS AND CLINICAL RELEVANCE Administration of cosyntropin IV at a dose of 0.5 microg/kg induced maximal cortisol secretion in healthy dogs. Serum cortisol concentration was reliably increased in all dogs after the administration of each of the 5 doses of cosyntropin. These data should be useful in subsequent studies to evaluate the hypothalamic-pituitary-adrenal axis in healthy and critically ill dogs.
Sizing Cleancache Allocation for Virtual Machines’ Transcendent Memory

The old virtualization idea and the new multicore technology now make it possible to consolidate multiple workloads on one physical host. This helps reduce the amount of idle resources. In particular, transcendent memory is a recent idea to gather idle memory into a pool that is shared by virtual machines (VMs). It can be viewed as a new level in the memory hierarchy, between main memory and disks. Cleancache is the part of transcendent memory that is used for caching the VMs' clean pages. This paper shows that a Cache Miss Equation can accurately capture observed cleancache behavior, despite its unusual design. The equation can be used to dynamically size and partition cleancache for the VMs. Experiments with a variety of workloads show that this equation-based allocation can help to drastically reduce disk reads and fairly allocate cleancache space.
The Knowledge Agenda

For most companies the immediate challenge is to create a knowledge‐based business which can capitalize on the opportunities afforded by the emerging knowledge economy. This includes the challenge of gaining acceptability within the organization of the theory and practice of Knowledge Management. It also includes the challenge of institutionalizing the Knowledge Management process, with attention to both sharing existing knowledge and creating and commercializing new knowledge.
On the non-existence of epsilon-uniform finite difference methods on uniform meshes for semilinear two-point boundary value problems

In this paper fitted finite difference methods on a uniform mesh with internodal spacing h, are considered for a singularly perturbed semilinear two-point boundary value problem. It is proved that a scheme of this type with a frozen fitting factor cannot converge e-uniformly in the maximum norm to the solution of the differential equation as the mesh spacing h goes to zero. Numerical experiments are presented which show that the same result is true for a number of schemes with variable fitting factors.
Electronic Medical Records Are Not Associated With Improved Documentation in Community Primary Care Practices

The adoption of electronic medical records (EMRs) in ambulatory settings has been widely recommended. It is hoped that EMRs will improve care; however, little is known about the effect of EMR use on care quality in this setting. This study compares EMR versus paper medical record documentation of basic health history and preventive service indicators in 47 community-based practices. Differences in practice-level documentation rates between practices that did and did not use an EMR were examined using the Kruskal—Wallis nonparametric test and robust regression, adjusting for practice-level covariates. Frequency of documentation of health history and preventive service indicator items were similar in the 2 groups of practices. Although EMRs provide the capacity for more robust record keeping, the community-based practices here do not use EMRs to their full capacity. EMR usage does not guarantee more systematic record keeping and thus may not lead to improved quality in the community practice setting.
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, usually called CADASIL, is an inherited condition that causes stroke and other impairments. This condition affects blood flow in small blood vessels, particularly cerebral vessels within the brain. The muscle cells surrounding these blood vessels (vascular smooth muscle cells) are abnormal and gradually die. In the brain, the resulting blood vessel damage (arteriopathy) can cause migraines, often with visual sensations or auras, or recurrent seizures (epilepsy).
Performance of data resampling methods for robust class discovery based on clustering

Data resampling techniques are increasingly used for assigning confidence to clustering results, in particular for tumor class discovery based on genomic data. One factor that determines the success of this approach is the capability of a resampling scheme to simulate the sampling variability by using the information of sparse sample data. We present a method for evaluating resampling performance based on model simulations. This method was applied to results of 40 cluster validity indices and one partition stability index obtained from 12 clustering procedures including different distance measures. The results were generated for benchmark data of five statistical models, gene expression profiles of three multi-class tumor sample data sets, four data sets of the widely used UCI repository, and spatiotemporal neuroimaging data. The results suggest a ranking of the three resampling techniques analyzed: perturbation (adding noise to the data) was more effective than subsampling and both clearly outperformed the bootstrapping technique in the detection of correct clustering consensus results. Due to the consistency of the results this ranking may have impact on the selection of a resampling method for the cluster validation in future studies. Moreover, intelligent control of the resampling parameters can increase the achievable confidence in clustering results.
Comparison of 111In-DOTA-Tyr3-octreotide and 111In-DTPA-octreotide in the same patients: biodistribution, kinetics, organ and tumor uptake.

UNLABELLED Scintigraphy with [111In-diethylenetriamine pentaacetic acid0-D-Phe1]-octreotide (DTPAOC) is used to demonstrate neuroendocrine and other somatostatin-receptor-positive tumors. Despite encouraging results, this 111In-labeled compound is not well suited for peptide-receptor-mediated radiotherapy of somatostatin-receptor-positive tumors. Another somatostatin analog, [1,4,7,10-tetraazacyclododecane-N,N',N",N'''-tetraacetic acid0, D-Phe1, Tyr3]-octreotide (DOTATOC), can be labeled with the beta-emitter 90Y in a stable manner. METHODS We compared the distribution, kinetics and dosimetry of 111In-DTPAOC and 111In-DOTATOC in eight patients to predict the outcomes of these parameters in patients who will be treated with 90Y-DOTATOC. RESULTS Serum radioactivity levels for the radiopharmaceuticals did not differ significantly 2-24 h after injection (P>0.05). Up to 2 h postinjection they were slightly, but significantly, lower after administration of 111In-DOTATOC (P < 0.01 at most time points). The percentage of peptide-bound radioactivity in serum did not differ after administration of either compound. Urinary excretion was significantly lower after administration of 111In-DOTATOC (P < 0.01). The visualization of known somatostatin-receptor-positive organs and tumors was clearer after administration of 111In-DOTATOC than after administration of 111In-DTPAOC. This was confirmed by significantly higher calculated uptakes in the pituitary gland and spleen. The uptake in the tumor sites did not differ significantly (P > 0.05), although in three of the four patients in whom tumor uptake could be calculated, it was higher after administration of 111In-DOTATOC. CONCLUSION The distribution and excretion pattern of 111In-DOTATOC resembles that of 111In-DTPAOC, and the uptake in somatostatin-receptor-positive organs and most tumors is higher for 111In-DOTATOC. If 90Y-DOTATOC shows an uptake pattern similar to 111In-DOTATOC, it is a promising radiopharmaceutical for peptide-receptor-mediated radiotherapy in patients with somatostatin-receptor-positive tumors.
Ventilation tube in adults with middle-ear effusion.

OBJECTIVE This study was conducted to analyze the data concerning otitis media with effusion (OME) to configure its etiology, symptomatology, and outcome in adults. METHOD A retrospective study of 198 consecutive cases (260 ears) of OME was conducted between July 1988 and June 1996. All of the patients were older than 16 years and were diagnosed for the first time. Tympanograms, initial symptoms, underlying diseases, extrusion of the ventilation tube, and recurrence rate of effusion were analyzed. RESULTS Sinusitis was usually seen in patients 16 to 29 and over 60 years old, whereas nasopharyngeal carcinoma was prevalent in patients 30 to 59 years old. Ear stuffiness (75.3%) was the most prevalent initial symptom, followed by hearing impairment (74.2%). One hundred seventy-five ears from 132 patients had been followed up for more than 2 years. In four ears, ventilation tubes were removed by instrument; the ventilation tubes in the remaining 171 ears of 128 patients extruded spontaneously within 20 months (8.6 months on average). Recurrence of effusion within 2 years was noted in 78.8% (78/99 ears) of patients with head and neck tumours and in 27.3% (12/44 ears) of patients with sinusitis. CONCLUSION Nasopharyngeal carcinoma and sinusitis were the main etiologies of OME in adults. In addition to treatment of sinusitis, nasopharyngeal check-up is mandatory in adults with OME.
A STUDY OF LIPID PROFILE IN HIV - POSITIVE PATIENTS ATTENDING GOVERNMENT GENERAL HOSPITAL, KURNOOL

The present study assessed the lipid profile of HIV - infected patients attending the Government General Hospital, Kurnool during the period of 2009 - 2010. Fasting serum levels of total cholesterol (TC), high density lipoprotein cholesterol (HDL - C), low density lipoprotein cholesterol (LDL - C), very low density lipoprotein cholesterol (VLDL - C) and triglyceride (TG) were determined in sixty HIV - positive subjects and sixty age - matched HIV - negative controls. The CD4 + T - lym phocyte counts of the HIV - positive subjects were assessed and the HIV - positive subjects were grouped into three based on their CD4 + levels as follows: Group I (CD4 + count < 200 cells/µl); group II (CD4 + count 200 - 499 cells/µl); group III (CD4 + count 5 00 cells/µl). The total cholesterol, HDL - C, LDL - C, VLDL - C, TG and CD4 + T - lymphocyte for the HIV - positive subjects were 4.64±0.23 mmol/L,
The Moving Fire Hydrant Experiment: Movement of Objects to a New Location Reelicits Marking in Rats

Three experiments were carried out to investigate the influence of object relocation on object marking in an open field by hooded and albino rats. Object marking was reelicited when an object was moved to a new location in the second half of an open field test. Control conditions revealed that an object briefly moved and returned to the original location elicited no more marking than a stationary object. The higher level of marking of the relocated object suggests that object marking may provide an index of spatial knowledge. The implication of spatial knowledge in controlling marking behavior is congruent with observations that rats with hippocampal damage show increased marking.
[Silencing of carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proliferation and induces apoptosis in human glioma SHG44 cells].

OBJECTIVE To investigate the effect of siRNA-induced silencing of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) on proliferation and apoptosis in human glioma SHG44 cells. METHODS Three pairs of specific siRNA targeting CEACAM1 were designed and synthesized, and then transiently transfected into SHG44 cells via cationic liposome transfection method. Transfection efficiency was examined by flow cytometry (FCM). Real-time quantitative PCR (qRT-PCR) and Western blotting were respectively used to detect CEACAM1 expression at mRNA and protein levels, and the proliferation ability and apoptosis of SHG44 cells after transfection were assessed by CCK-8 assay and FCM in combination with annexin V-FITC/PI staining, respectively. The expression levels of cleaved caspase-3 and cleaved poly(ADP-ribose)polymerase (PARP) proteins were detected by Western blotting. RESULTS The efficiency of CEACAM1 siRNA transfection into human SHG44 cells were 85%. Forty-eight hours after the three pairs of specific CEACAM1 siRNA were transfected into SHG44 cells, qRT-PCR and Western blot results showed that the expression of CEACAM1 mRNA and protein were significantly inhibited compared with those in the blank control and the negative control groups, and the most significant interference effect was CEACAM1-siRNA3. The proliferation of SHG44 cells was inhibited and the apoptosis rate was raised by the CEACAM1-siRNA transfection. The expression levels of cleaved caspase-3 and cleaved PARP proteins were up-regulated after silencing of CEACAM1. CONCLUSION The siRNA-mediated CEACAM1 silencing can inhibit the proliferation and promote the apoptosis in human glioma SHG44 cells. CEACAM1 gene may be used as a potential therapeutic target of glioma.
Approaches to implementation of a repairable distributed recovery block scheme

The authors previously proposed (1984) the basic concept of the distributed recovery block (DRB) scheme as an approach to uniform treatment of hardware and software faults in real-time applications. Design issues that arise in implementing the DRB scheme are discussed together with some promising approaches. Issues in extending the DRB scheme with the capability of reincorporating a repaired node without disrupting the real-time computing service are also discussed. An experimental implementation of the repairable DRB scheme into a real-time distributed computer system (DCS) testbed and subsequent measurement of the system performance demonstrated the fast forward recovery capability and the logical soundness of the scheme. <<ETX>>
Contribution aux tests de vacuité pour le model checking explicite. (Contribution to emptiness checks for explicit model checking)

L'approche automate pour le model checking de proprietes temporelles a temps lineaire est une technique classique de verification formelle de systemes concurrents. Un systeme, ainsi qu'une propriete qu'on souhaite y verifier, sont modelises sous forme d’omega-automates reconnaissant des mots infinis. Des manipulations de ces automates (produit synchronise et test de vacuite) permettent d'etablir si le systeme verifie la propriete ou non. Dans cette these nous nous focalisons sur un type particulier d'omega-automates qui permettent une representation concise des proprietes d'equite faible: les automates de Buchi generalises bases sur les transitions (TGBA ou Transition-based Generalized Buchi Automata). Dans un premier temps, nous brossons un apercu des algorithmes de verification existant et nous en proposons de nouveaux traitant efficacement les automates generalises forts. Dans un second temps, l'analyse des composantes fortement connexes de l'automate de la propriete nous a conduit a elaborer une decomposition de cet automate. Cette decomposition se focalise sur les automates multi-forces et permet une parallelisation naturelle des model-checkers. Enfin, nous avons propose les premiers tests de vacuite paralleles pour les automates generalises. De plus, tous ces tests sont lock-free a la difference de ceux de l’etat de l’art. Toutes ces techniques ont ensuite ete implementees et evaluees sur un jeu de test consequent.
Decreased beta-adrenergic receptors on polymorphonuclear leukocytes after adrenergic therapy.

β-ADRENERGIC catecholamines, which modulate function of a variety of tissues, are assumed to act by initially binding to receptors on target-cell plasma membranes, thereby activating adenylate cyclase and stimulating generation of adenosine 3′:5′-monophosphate (cyclic AMP). In addition to activating adenylate cyclase, β-adrenergic agonists commonly have a second action — regulation of responsiveness of the target cells. Thus, continued treatment with such agonists often results in decreased cellular response. This self-regulation of target-cell responsiveness, variously termed refractoriness, desensitization and down-regulation, has been observed with catecholamines, as well as with a number of other hormonal agonists.1 2 3 For catecholamines, studies in several experimental .
An unusual case of an acute hemolytic transfusion reaction caused by an autoanti-I

Abstract In general, naturally occurring cold autoagglutinins react optimally at low temperatures. We describe a young child who experienced an acute hemolytic transfusion reaction by an unusual autoanti-I. The IgM autoanti-I was detected at 4°C (titer 256) and also reacted at 30°C. This case highlights the potential hazard of transfusing units of blood immediately upon removal from the blood refrigerator, especially into neonates and children of small stature. Immunohematology2011;27:101–103.
Xerostomia and medications among 32-year-olds

Objective. To describe the prevalence and associations of xerostomia among adults in their early thirties, with particular attention to medication exposure as a putative risk factor. Material and Methods. The prevalence and associations of xerostomia were investigated among 32-year-old participants in a long-standing prospective cohort study. Some 950 individuals were assessed at ages 26 and 32 years, with medications being recorded on both occasions. Results. The prevalence of xerostomia was 10.0% (with no apparent gender difference), and was significantly higher among those taking antidepressants (odds ratio = 4.7), iron supplements (OR = 4.1) or narcotic analgesics (OR = 2.4). Those taking antidepressants at both ages 26 and 32 years had 22 times the odds of reporting xerostomia. Conclusion. Xerostomia may be a problem for a sizeable minority of young adults.