Miracle-dz/UniFAR-FTUs huggingface dataset:
Flight to Quality and Canadian Mutual Fund Flows

This paper examines the asset allocation decisions of mutual fund investors, focusing on flight to quality considerations. Specifically, we study monthly net flows to the universe of Canadian mutual funds between 1991 and 2005 to see how investors vary flows across fund categories as economic conditions change. Using the default spread, term spread and short term interest rate as proxies for economic conditions, we find that an improvement (deterioration) in Canadian economic conditions causes investors to direct flows away from (towards) fixed income-type funds and towards (out of) equity based funds. For example, a one standard deviation increase in the term spread (1.13%) results in an 84% increase and a 74% decrease in the percentage of flows directed at Canadian equity and money market funds respectively. To further assess the significance of shifting risk preferences, we examine the flows to equity and money market funds surrounding three major crises: the Long Term Capital Management debacle, the Y2K problem and the 9/11 terrorist attacks. Each episode is accompanied by significant flows into money market funds and out of equity funds. For example, the August 1998 Long Term Capital Management failure sees Canadian investors move $1,850 million into money market funds and $627 million out of equity funds. Our results provide evidence both of a strong flight-to-quality motivation underlying aggregate mutual fund flows and of rationality in mutual fund investor asset allocation decisions.
The role of pharmacists in the pharmaceutical care of asthma patients in Yogyakarta, Indonesia: the patients’ views

Abstract Introduction: Community pharmacists are one of the most frequently accessed health professionals who can be involved in the provision of ongoing asthma management within the primary care setting. The aim of this study was to identify patients’ views regarding current asthma care provided by their pharmacists and their perspectives on future pharmacy-based asthma services. Methods: This is a qualitative approach with an interview guide. Asthma patients were purposively selected. Interviews were conducted from April to June 2017. Patient’s opinions about asthma and its management and their experiences regarding asthma care provided by pharmacists were collected. Data were analyzed using content analysis. Results: Thirty-three interviews were conducted. Asthma literacy was low. There was dis-engagement with the health care system, with only a few participants trusting conventional health care professionals. Alternative medicine systems and practitioners were better trusted and participants had strong preferences for family/peer involvement in their asthma care. Participants also had misunderstandings regarding their asthma disease and medications. Participants had experienced little pharmaceutical care provided by pharmacists but would welcome it in the future. Conclusion: Given the accessibility of community pharmacy venues and readiness of the profession for more involved care of chronic disease patients, it may be recommended that Indonesian community pharmacists should adopt the provision of pharmaceutical care models for asthma. Such pharmaceutical care models need to incorporate patients’ unique sociocultural health beliefs, preferences for alternative medicines and family/social peer involvement as well as stronger collaboration between pharmacists and physicians.
Correlates of Successful Rheumatoid Arthritis Flare Management: Clinician-driven Treatment, Home-based Strategies, and Medication Change

Objective. Describe strategies used to manage rheumatoid arthritis (RA) flares that contribute to a successful postflare outcome. Methods. Data were collected from the BRASS registry, including clinical and patient-reported outcomes, and a survey with a Likert scale assessing postflare symptoms (better, unchanged, or worse). A logistic regression analysis adjusting for age, sex, flare number in the past 6 months, flare pain severity, home management, clinical consultation, and medication change was performed to evaluate factors influencing flare outcome. Results. Of 503 participants, 185 reported at least 1 flare that had resolved in the past 6 months, with median (interquartile range) 28-joint count Disease Activity Score based on C-reactive protein 3 score 2.1 (1.7–2.8). Compared with RA symptoms before the flare, 22 (12%) patients felt worse, 125 (68%) were unchanged, and 38 (20%) felt better. To manage flares, 72% of patients used home-based remedies, 23% sought clinical consultation, and 56% made medication change. Of 103 patients who changed medication, 70% did so without seeking clinical advice. Making a medication change (OR 3.48, 95% CI 1.68–7.21) and having lower flare pain (OR 0.83, 95% CI 0.71–0.97) were associated with better flare outcome. Conclusion. Flares occur frequently even in patients with low disease activity. Independent of home-based or clinically guided care, making a medication change and having less severe pain during a flare were associated with better flare outcomes. Of interest, the decision to change medications was frequently made without clinical advice. Future studies might address how best to intervene when patients experience flares and whether patient-initiated medication changes have adverse outcomes.
Depressive disorders in patients who seek cosmetic surgery: a broad and updated view

Introduction: Aesthetic surgery can improve the quality of life of patients, but some candidates for the procedure have depressive disorders (DDs) that may develop, in the postoperative period, in a disastrous manner from a psychological point of view and even progress to suicide. The prevalence of DDs in cosmetic surgery patients is 20% on average and reaches 70%. This article aims to review depression and aesthetic surgery as well as to alert and educate plastic surgeons on the growing number of these patients in clinical settings. It also aims to guide surgeons to the appropriate approach and specific behaviors with these patients. Methods: A search was performed in MEDLINE/PubMed and Embase, and key words were entered, including “cosmetic surgery,” “depression,” “mood disorders,” “depressive disorder,” “depressive symptoms,” and “suicide and plastic surgery. ” Results: The success of plastic surgery depends a great deal on the selection of patients for the procedure. Suspect patients, patients with elevated depressive symptoms in questionnaires (such as the BDI), and patients with psychopathology “markers” should be forwarded to a psychiatrist for proper evaluation. Conclusion: Due to the high prevalence of DDs in aesthetic plastic surgery patients, every plastic surgery patient should be evaluated properly to identify those with possible DDs in the preoperative period, and those should be forwarded to a psychiatrist, thus avoiding an unfavorable postoperative psychological evolution. ■ ABSTRACT
High prevalence of a globally disseminated hypervirulent clone, Staphylococcus aureus CC121, with reduced vancomycin susceptibility in community settings in China.

OBJECTIVES Most vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA) are derived from hospital-associated MRSA due to treatment failure; however, the prevalence of hVISA/VISA in community settings remains unclear. METHODS Four hundred and seventy-six community-associated isolates were collected between 2010 and 2011 during national surveillance for antimicrobial resistance in 31 county hospitals across China. Drug susceptibility evaluation and mecA detection were performed by using broth microdilution and PCR analysis, respectively. hVISA/VISA were identified by using macro-Etest and a modified population analysis profile (PAP)-AUC method. The genetic features of all hVISA/VISA isolates were genotyped. RESULTS Among 476 isolates, MRSA and MSSA accounted for 19.7% (n = 94) and 80.3% (n = 382), respectively. Two VISA and 36 hVISA isolates were identified by PAP-AUC testing. The VISA isolates and 29 of the hVISA isolates were MRSA. The proportion of hVISA/VISA was significantly higher in MRSA (30.9%) than in MSSA (1.8%). The hVISA/VISA isolates were assigned to 18 STs classified into seven clonal complexes (CCs). CC121 (n = 12) followed by ST239 (n = 11) was the most prevalent hVISA/VISA clone. All ST239-hVISA/VISA were MRSA, while 12 CC121-hVISA isolates included 6 MSSA and 6 MRSA isolates. SCCmec III was predominant among MRSA-hVISA/VISA isolates. agr I and agr IV were detected in ST239 and CC121, respectively. All except two strains were positive for Panton-Valentine leucocidin genes. CONCLUSIONS To the best of our knowledge, this is the first report of CC121 as a prevalent hVISA clone in community settings, highlighting the necessity of surveillance and stricter infection control measures for this globally disseminated lineage.
A Survey on Current Repertoire for 5G

Cellular technology progressed miraculously in the last decade. It has redefined communication paradigm. Statistics provided by Ericson and Cisco show the number of mobile connected devices will reach figures of 9.2 billion and 11.6 billion respectively by 2020. Overall connected devices will surpass 50 billion then. Extremely higher data rates, zero latency, massively scalable, connecting everything anywhere is what that 5G promises. To meet such ambitious goals which apparently seems challenging, the tools and technologies that mobile communication has in its repertoire and what it needs more either enhancement in existing solutions or new solution or joint venture of both, is a question that demands an answer. To realize 5G, evolution and revolution both approaches are being employed. Evolution seeks enhancements in existing technologies while revolution looks for new innovations and technologies. Extension in frequency spectrum, network densification, MIMO, carrier aggregation, CentralizedRAN, HetNets, and Network Functionality Virtualization are the key enablers. This paper disseminates information about ongoing research and development of 5G.
Using Precipitation Observations in a Mesoscale Short-Range Ensemble Analysis and Forecasting System

A simple method to assimilate precipitation data from a synthesis of radar and gauge data is developed to operate alongside an ensemble Kalman filter that assimilates hourly surface observations. The mesoscale ensemble forecast system consists of 25 members with 30-km grid spacing and incorporates variability in both initial and boundary conditions and model physical process schemes. The precipitation assimilation method only incorporates information on when and where rainfall is observed. Model temperature and water vapor mixing ratio profiles at each grid point are modified if rainfall is observed but not predicted, or if rainfall is predicted but not observed. These modifications act to either increase or decrease, respectively, the likelihood that precipitation develops at that grid point. Two cases are examined in which this technique is applied to assimilate precipitation data every 15 min from 1200 to 1800 UTC, while hourly surface observations are also assimilated at the same time using the more sophisticated ensemble Kalman filter approach. Results show that the simple method for assimilating precipitation data helps the model develop precipitation where it is observed, resulting in the precipitation area being reproduced more accurately than in the run without precipitation-data assimilation, while not negatively influencing the positive results from the surface data assimilation. Improvement is also seen in the reliability of precipitation probabilities fo ra1m m h 1 threshold after the assimilation period, indicating that assimilating precipitation data may provide improved forecasts of the mesoscale environment for a few hours.
A Pilot Study of Side Effects of Cancer Therapies and their Impact on Satisfaction with Life

Abstract This survey aimed at getting a first insight into diverse side effects and their association with satisfaction with life as well as the use of complementary and alternative medicine (CAM) in cancer patients. A total of 100 patients in a German University Hospital were included. General side effects like fatigue, fever, headache, limb pain and sleep disorders had a significant influence on the patients’ satisfaction with life (p = .034 and p = .032, respectively). Concerning CAM, we could not detect any association between the frequency of side effects and the use of CAM. Improving the treatment of side effects may have a strong impact on patients’ satisfaction with life.
S100A4: a novel partner for heat shock protein 47 in antler stem cells and insight into the calcium ion-induced conformational changes

Abstract S100A4 is a multiple-function protein highly expressed in tumor or stem cells. We found S100A4 was a novel protein partner for heat shock protein 47 (HSP47) in deer antlerogenic periosteum cells (AP cells), indicating that S100A4 could bind with HSP47. S100A4 had both calcium-dependent and calcium-independent patterns (labeled as SCd and SCi, respectively) to execute different biological activities. Homology models of HSP47, SCd and SCi were constructed. HSP47:collagen model, HSP47:collagen I-V, HSP47:SCd and HSP47:SCi complexes were built using ZDOCK software. Together with free SCd and SCi, 200 ns molecular dynamic (MD) simulations were performed to analyze binding free energies and SCi/SCd conformational changes. The energetic results showed that SCi had the strongest affinity to HSP47, and followed by collagens. SCd had little interaction with HSP47. Decomposition energy results showed that collagen model interacted with HSP47 mainly though neutral amino acids. When SCi bound with HSP47, the majority of mediated amino acids were charged. These results indicated that SCi could compete with collagen on the binding site of HSP47. Root mean square fluctuation (RMSF) values and cross-correlation matrices of principal component analysis (PCA) were calculated to evaluate the SCi/SCd structural variation during MD simulation. Both HSP47 and Ca2+ could stabilize the conformation of SCi/SCd. The loops interacting with Ca2+s and linking the two EF-hand motifs were impacted particularly. The relative moving directions of α-helices in EF-hands were distinct by the binding effect of HSP47 and Ca2+. We found that SCi may regulate the differentiation of AP cells by disturbing the interaction between HSP47 and collagen. Communicated by Ramaswamy H. Sarma
Crystal structures of the recombinant β-factor XIIa protease with bound Thr-Arg and Pro-Arg substrate mimetics.

Coagulation factor XII (FXII) is a key initiator of the contact pathway, which contributes to inflammatory pathways. FXII circulates as a zymogen, which when auto-activated forms factor XIIa (FXIIa). Here, the production of the recombinant FXIIa protease domain (βFXIIaHis) with yields of ∼1-2 mg per litre of insect-cell culture is reported. A second construct utilized an N-terminal maltose-binding protein (MBP) fusion (MBP-βFXIIaHis). Crystal structures were determined of MBP-βFXIIaHis in complex with the inhibitor D-Phe-Pro-Arg chloromethyl ketone (PPACK) and of βFXIIaHis in isolation. The βFXIIaHis structure revealed that the S2 and S1 pockets were occupied by Thr and Arg residues, respectively, from an adjacent molecule in the crystal. The Thr-Arg sequence mimics the P2-P1 FXIIa cleavage-site residues present in the natural substrates prekallikrein and FXII, and Pro-Arg (from PPACK) mimics the factor XI cleavage site. A comparison of the βFXIIaHis structure with the available crystal structure of the zymogen-like FXII protease revealed large conformational changes centred around the S1 pocket and an alternate conformation for the 99-loop, Tyr99 and the S2 pocket. Further comparison with activated protease structures of factors IXa and Xa, which also have the Tyr99 residue, reveals that a more open form of the S2 pocket only occurs in the presence of a substrate mimetic. The FXIIa inhibitors EcTI and infestin-4 have Pro-Arg and Phe-Arg P2-P1 sequences, respectively, and the interactions that these inhibitors make with βFXIIa are also described. These structural studies of βFXIIa provide insight into substrate and inhibitor recognition and establish a scaffold for the structure-guided drug design of novel antithrombotic and anti-inflammatory agents.
Design and Simulation of FC Plug-in Hybrid Bus with Ultracapacitors

The plug-in hybrid vehicle has been taken as one of the main streams of electric vehicles world wide with the development of battery technology and the remaining obstacles by the fuel cell to be broken through. Fuel cell plug-in vehicle will follow the engine plug-in vehicle because of the more and more strict control of green house gas emission. At this moment, lithium battery is still expensive and safety problem remains. The performance of ultra capacitor has been significantly improved and the price goes down rapidly because of being used on harbor vehicle and mechanical facilities such like container/cargo cranes in-small-batch. It has become a popular ESS for energy regeneration such like the transit buses. The paper will present the advantage and the performance of a FC plug-in hybrid transit bus with ultracapacitors and NiMH batteries. The design and simulation will be covered in the paper.
Essential role of autophagy in resource allocation during sexual reproduction

ABSTRACT Sexual reproduction is the most common form of reproduction among eukaryotes, which is characterized by a series of massive cellular or tissue renovations. Recent studies have revealed novel functions of autophagy during sexual reproductive processes, ranging from yeast to mammals. In mammals, autophagy is indispensable for spermatogenesis and oogenesis, and it participates in early embryonic development and maternal-fetus crosstalk to ensure the development of embryos or fetuses. Thus, autophagy provides the molecular basis for resource allocation among parents and their offspring, providing an important way to benefit the next generation. Abbreviations: ATG: autophagy-related; Becn1: beclin 1, autophagy related; CMA: chaperone-mediated autophagy; epg: ectopic PGL granules; ES: ectoplasmic specialization; EVTs: extravillous trophoblasts; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; PCD: programmed cell death; PTB: preterm birth; STB: syncytiotrophoblast
The Role of Couple Compatibility as Social Capacity in Sustainable Community

Marital adjustment denotes emotional stability, intellectual efficiency and social effectiveness people. Marriage is the key to whole some adjustment involvement and satisfaction. Marriage is our most common life style. One definition of adjustment is adaptation behavior that permits us to meet the demand of the environment. Also defined as a response to stress. Aim of study investigated the relationship of emotional and social adjustment with marital satisfaction. This research is applied and the research method is "descriptive – analytical". The method of data collected is field and questionnaire. Therefore were used 180 questionnaires. Also, was used "SPSS" method for analyzing data also, was used "SPENIER & ENRICH" questionnaire. On the other hand, case study, couple of ROZBEH consultant center. So, sample size is 100 couple. Key word: Couple compatibility, social capital, community, Iran
A comprehensive review of cytochrome P450 2E1 for xenobiotic metabolism

Abstract Cytochrome P450 2E1 (CYP2E1) plays a vital role in drug-induced hepatotoxicity and cancers (e.g. lung and bladder cancer), since it is responsible for metabolizing a number of medications and environmental toxins to reactive intermediate metabolites. CYP2E1 was recently found to be the highest expressed CYP enzyme in human livers using a proteomics approach, and CYP2E1-related toxicity is strongly associated with its protein level that shows significant inter-individual variability related to ethnicity, age, and sex. Furthermore, the expression of CYP2E1 demonstrates regulation by extensive genetic polymorphism, endogenous hormones, cytokines, xenobiotics, and varying pathological states. Over the past decade, the knowledge of pharmacology, toxicology, and biology about CYP2E1 has grown remarkably, but the research progress has yet to be summarized. This study presents a timely systematic review on CYP2E1’s xenobiotic metabolism, genetic polymorphism, and inhibitors, with the focus on their clinical relevance for the efficacy and toxicity of various CYP2E1 substrates. Moreover, several knowledge gaps have been identified towards fully understanding the potential interactions among different CYP2E1 substrates in clinical settings. Through in-depth analyses of these knowns and unknowns, we expect this review will aid in future drug development and improve management of CYP2E1 related clinical toxicity.
Water Quality and Ecotoxicity Assessment in Surface Waters from Cubatão River and Surroundings, São Paulo, Brazil

The monitoring of water bodies means the attempt of protecting vulnerable groups of organisms inhabiting streams and rivers. Industrial and domestic discharges may worsen the water quality and affect biological balance, structure and the functioning of the ecosystem. Cubatao City, is one of the largest industrial centers in Brazil and in Latin America, where the constant discharge of effluents into Cubatao River and its tributaries caused a degradation scenario in the hydrographic basin of the region. The objective of this study was to evaluate the acute and chronic effects of surface water from Cubatao River and two of its tributaries (Pereque and Piloes) by ecotoxicological assays. In addition, physical chemical parameters were analyzed. Ceriodaphnia dubia and Vibrio fischeri were exposed-organisms during the studied period. The study was conducted between 2010 and 2011 in four campaigns and nine sites along the basin of Cubatao River. The ecotoxicity was measured by Vibrio fischeri bioluminescence, EC50 values ranging from 31.25% to 71.61%. In contrast, based on a bioequivalence t-test statistical analysis, the results obtained with Ceriodaphnia dubia revealed no toxicity in the sampling sites. A critical analysis of raw data of luminescence was carried out showing higher values during the 2nd campaign. From the numbers obtained for physical-chemical parameters P5 was far the worst due to chlorides, hardness and conductivity. From the Pearson correlation analysis carried out with toxicity to V. fischeri and the physical chemical parameters, the dissolved oxygen in water resulted in a moderate positive correlation. Sediment contamination was also demonstrated in the region.