Miracle-dz/UniFAR-FTUs huggingface dataset:
A retrospective evaluation of patients with myelodysplastic syndrome

Aim: To determine our results by examining patient's files who we followed up by myelodysplastic syndrome (MDS) diagnosis between 2005 and 2009 as retrospectively and to compare the accordance of our results with literature. Methods: We examined 55 patient's files who got MDS diagnosis in 4 year-term. Complete blood count, biochemical analysis, peripheral spread, bone marrow aspiration, bone marrow biopsy examinations, cytogenetic and fluorescence in situ hybridization (FISH) analyses were made for all cases. Results: Our patient's age average was 69 and when classified according to WHO criterions at the diagnosis time, % 13 (23,6) of cases got diagnosed with RA-RARS, % 29 (52,7) with RCMD-RS, %5 (9,1) with RAEB-1, % 4 (7.3) with RAEB-2, % 3 (5.5) with MDS 5q and % 1 (1.8) with secondary MDS. % 52 of the patients had normal cytogenetic structure. No relation was determined between patients’ diagnosis and international prognostic scoring system (IPSS) scores. During the 4 year-term, our 13 patients died. 6 of these cases died by reason of transforming to acute myeloid leukemia (AML), and 7 patients died because of infection. Mean survival time of cases that died was 6 (1-7) months as of the diagnosis date. Whereas 8 cases were over 70 ages, 5 of our cases were under 70 ages. Conclusion: MDS is a disease that ranges between anemia and AML and requires cytogenetic trials for diagnosis along bone marrow aspiration and biopsy for the purpose of determining the treatment regimen and prognosis. Determining the IPSS scores of patients by obtained outcomes is required. Risk of transforming to acute leukemia and susceptibility to infection are important in terms of mortality. Overage of patient population restricts the treatment regimens. Age must be an important factor for prognosis and treatment choice.
Research and Implementation of Intelligent Network Disk Cluster Storage Technique

Intelligent network disk(IND) cluster is a new scheme for mass storage.In order to realize its storage function,a computer lan network with groups of IND is constructed and several important crux technique have been investigated in detail.By adopting centralized management,decentralized service,backup supported and real-time monitor strategy,not only concurrent caused by read and write request are controlled so efficiently that batch files are transferred in security and also could auto-regulate workload balance for system working in normal condition.Lots of experimental data show that intelligent control program and intelligent algorithm are correct and reasonable.This scheme tallies with original idea of design.IND cluster is a available,scalable,secure,simple and convenient,flexible and low-priced mass storage system.
AUTONOMOUS INTELLIGENT AGENT INDEMNIFICATION IN SLA (IAIS) ARCHITECTURE FOR EFFORTLESS MONITORING OF SLA VIOLATIONS

Increasing demand for cloud computing is the reason for its ubiquitous growth in today’s world. Enterprise consumers from large organization to small organization are preferring the services such as IaaS, SaaS and PaaS for their business growth with minimal cost because of on demand pay model. To employ such services for their organization, the cloud consumer and cloud service providers(CSP) has to consensus a agreement between them popularly known as Service Level Agreement(SLA). These SLA usually contains the type of service,Target Period, Quality of Service (QOS) properties, and Penalties called Service Level Objective (SLO) that has to be maintained during the service provision. This necessitates for the need to continuously monitor SLA violation to enforce penalties on the wronged one. Often this SLA management such as SLA monitoring and reporting is usually done by third party entity. But often these third party entities failed to ensure trust and compliance among the cloud consumers and CSPs. Henceforth in this paper, we propose a use of Intelligent Agent to monitor the SLO on behalf of the cloud consumers and report them of any discrepancies. We propose anIntelligent Agent Indemnification in SLA (IAIS) Architecture where the SLA management is entrusted to the dynamic, autonomous intelligent agent which is considered to be a substitute for human. We also measure some of the Key Performance Indicators and establish a threshold value to identify SLA violation based on threat threshold and will verify the same using simulation for effortless and efficient performance of the proposed framework.
Effects of Reproductive Maturity on Neuroplasticity in Male Bumble Bees (Bombus impatiens)

Within the span of an insect's lifetime, new synaptic connections between neurons are made in response to age and experience. This neuroplasticity leads to anatomical changes within individual brain regions that represent investment in different brain functions. The neuroplasticity of female bumble bees has been well studied, but almost nothing is known about how the male bee brain responds to life experiences. Due to the complex sensory requirements of mate finding and copulation for males, neuroplasticity is likely to be an important component of reproduction . These sensory requirements include olfactory and optic inputs, which are processed in the calyces of insect brains. The aim of my project is to document anatomical changes in brain structures associated with reproductive maturity in male bumble bees (Bombus impatiens). I hypothesized that neurological investment in optic and olfactory function will change as male bees reach reproductive maturity, as they use these senses to locate mates . Because the mushroom body calyces are the structures that receive inputs from optic and antenna I lobes, I predicted that the volumes of these mushroom body calyces will increase in volume as the bees age. My work initially consisted of designing a unique protocol, then caring for the microcolonies that produced the males used in the study. Males were collected either promptly after emerging or ten days later, then sacrificed for the purpose of investigating their brains. The brains were dissected, cleaned, and bleached using a protocol specific to this project. Using confocal microscopy, brain images were taken at 5 μm intervals, which were then traced using lmageJ software to create 3D renderings . Volumetric measurements were obtained for individual brain structures, then analyzed to procure the
The Management of Hypertension in People With Diabetes

According to the 2017 American College of Cardiology (ACC) and American Heart Association (AHA) guidelines, unmanaged hypertension is responsible for more cardiovascular-related deaths in the United States than any modifiable risk factor except smoking. Its prevalence depends on the blood pressure used to classify patients. Estimates using ACC/AHA criteria of 130/80 mmHg now suggest 46% or nearly half the US population has high blood pressure. A study from the American Heart Journal found people with diabetes are twice as likely to have hypertension compared to others at the same age without diabetes and have an overall prevalence of 80%. The high prevalence of hypertension in people with diabetes elevates their risk for the development of microand macrovascular complications. Both contribute to morbidity and mortality in people with diabetes, but data from the UKPDS trial found the leading cause of death is due to macrovascular disease. The purpose of this article is to review the application of the 2017 ACC/AHA blood pressure guidelines to people with diabetes.
Assessing colitis ex vivo using optical coherence elastography in a murine model.

Background Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that causes regions of ulceration within the interior of the colon. UC is estimated to afflict hundreds of thousands of people in the United States alone. In addition to traditional colonoscopy, ultrasonic techniques can detect colitis, but have limited spatial resolution, which frequently results in underdiagnoses. Nevertheless, clinical diagnosis of colitis is still generally performed via colonoscopy. Optical techniques such as confocal microscopy and optical coherence tomography (OCT) have been proposed to detect UC with higher resolution. However, UC can potentially alter tissue biomechanical properties, providing additional contrast for earlier and potentially more accurate detection. Although clinically available elastography techniques have been immensely useful, they do not have the resolution for imaging small tissues, such as in small mammalian disease models. However, OCT-based elastography, optical coherence elastography (OCE), is well-suited for imaging the biomechanical properties of small mammal colon tissue. Methods In this work, we induced elastic waves in ex vivo mouse colon tissue using a focused air-pulse. The elastic waves were detected using a phase-stabilized swept source OCE system, and the wave velocity was translated into stiffness. Measurements were taken at six positions for each sample to assess regional sample elasticity. Additional contrast between the control and diseased tissue was detected by analyzing the dispersion of the elastic wave and tissue optical properties obtained from the OCT structural image. Results The results show distinct differences (P<0.05) in the stiffness between control and colitis disease samples, with a Young's modulus of 11.8±8.0 and 5.1±1.5 kPa, respectively. The OCT signal standard deviations for control and diseased samples were 5.8±0.3 and 5.5±0.2 dB, respectively. The slope of the OCT signal spatial frequency decay in the control samples was 92.7±10.0 and 87.3±4.7 dB∙µm in the colitis samples. The slope of the linearly fitted dispersion curve in the control samples was 1.5 mm, and 0.8 mm in the colitis samples. Conclusions Our results show that OCE can be utilized to distinguish tissue based on stiffness and optical properties. Our estimates of tissue stiffness suggest that the healthy colon tissue was stiffer than diseased tissue. Furthermore, structural analysis of the tissue indicates a distinct difference in tissue optical properties between the healthy and UC-like diseased tissue.
Giant Protruding Nodular Fasciitis of the Anterior Chest Wall Clinically Mimicking a Soft Tissue Sarcoma

Nodular fasciitis (NF) is a benign reactive proliferation of myofibroblasts that predominantly occurs subcutaneously. Commonly, it presents as a rapidly growing swelling in 4-8 weeks. NF mostly occurs in adults aged 20-50 years and usually has a diameter < 3‐4 cm. Giant NF with a diameter > 4 cm is rare. Owing to its rapidly growing nature, a precise clinical diagnosis is difficult; it is frequently misdiagnosed as an aggressive or malignant tumor. Herein, we present the case of a 15-year-old male who presented with a large protruding mass on the anterior chest wall. The tumor appeared clinically malignant as it was protruding and had doubled in size within a few weeks, reaching approximately 8 × 6 cm. Furthermore, the tumor separated and fell off spontaneously due to its large size. As the remaining tumor continued to grow rapidly, surgery was performed. Following wide tumor resection, no recurrence, metastases, or other complications were noted 1 year postsurgery. NF was diagnosed after pathological evaluation, including immunohistochemical analysis, molecular genetic testing, and cytogenetic testing via fluorescence in situ hybridization analysis. Knowledge of the atypical clinical course and a combination of histopathological examinations are necessary to accurately diagnose NF.
MODS and/or TLA techniques: a systematic review and meta-analysis for active tuberculosis diagnosis and an evaluation of their cost-effectiveness and feasibility

OBJECTIVE: A systematic review and meta-analysis was performed to compare Microscopic-Observation Drug Sensitivity (MODS), Thin Layer Agar (TLA) and reference standards for sensitivity and specificity for tuberculosis detection and other characteristics. A questionnaire was conducted to evaluate the feasibility, costs and practical aspects of implementation of MODS/TLA.METHODS: A random effects meta-analysis to estimate the sensitivity and specificity was performed. A self-administered questionnaire was sent to laboratories using MODS/TLA.RESULTS: The overall sensitivity and specificity for MODS were 92% and 97% respectively and for TLA, they were 83% and 98% respectively. Equipment costs and training costs were moderate, costs for materials were low and labour costs were high.CONCLUSION: MODS and TLA appear to offer simple, inexpensive yet rapid and accurate diagnostic tools for active TB. Overall, costs were moderate to implement MODS/TLA. Important unresolved issues for further investigation include the cost-effectiveness and optimal methods for quality assurance of these TB diagnostic tools. %%%%OBJECTIF: Une revue systematique et meta-analyse a ete effectuee pour comparer Microscopic-Observation Drug Sensitivity (MODS), Thin Layer Agar (TLA) et normes de reference pour la sensibilite et la specificite pour la detection de la tuberculose. Un questionnaire a ete menee pour evaluer la faisabilite et les couts de MODS/TLA.METHODES: Un meta-analyse anx effets aleatoires pour estimer la sensibilite et la specificite a ete realisee. Le questionnaire a ete envoye aux laboratoires utilisant MODS/TLA.RESULTATS: La sensibilite et la specificite pour MODS etaient 92% et 97% respectivement et pour TLA, ils etaient 83% et 98% respectivement. Les couts initiaux etaient moderees, les couts des materiaux etaient faibles et les couts salariaux etaient eleves.CONCLUSION: MODS/TLA sont des outils diagnostiques peu couteux, rapides et precises. Les couts pour la mise en oeuvre etaient moderes mais le cout-efficacite et la faisabilite pour les outils diagnostiques de TB sont deux domaines importants a etudier.
Recognition of a person named entity from the text written in a natural language

This work is devoted to the semantic analysis of texts, which were written in a natural language. The main goal of the research was to compare latent Dirichlet allocation and latent semantic analysis to identify elements of the human appearance in the text. The completeness of information retrieval was chosen as the efficiency criteria for methods comparison. However, it was insufficient to choose only one method for achieving high recognition rates. Thus, additional methods were used for finding references to the personality in the text. All these methods are based on the created information model, which represents person’s appearance.
Efficient background model based on multi-level feedback for video surveillance

Segmentation of moving objects from video sequences is the fundamental step in intelligent surveillance applications. Numerous methods have been proposed to obtain object segmentation. In this paper, we present an effective approach based on the mixture of Gaussians. The approach makes use of a feedback strategy with multiple levels: the pixel level, the region level, and the frame level. Pixel-level feedback helps to provide each pixel with an adaptive learning rate. The maintenance strategy of the background model is adjusted by region-level feedback based on tracking. Frame-level feedback is used to detect the global change in scenes. These different levels of feedback strategies ensure our approach’s effectiveness and robustness. This is demonstrated through experimental results on the Change Detection 2014 benchmark dataset.
Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain

The most common neurological complication in patients receiving successful combination antiretroviral therapy (cART) is peripheral neuropathic pain. Data show that distal symmetric polyneuropathy (DSP) also develops along with murine acquired immunodeficiency syndrome (MAIDS) after infection with the LP-BM5 murine retrovirus mixture. Links between cannabinoid receptor 2 (CB2R) and peripheral neuropathy have been established in animal models using nerve transection, chemotherapy-induced pain, and various other stimuli. Diverse types of neuropathic pain respond differently to standard drug intervention, and little is currently known regarding the effects of modulation through CB2Rs. In this study, we evaluated whether treatment with the exogenous synthetic CB2R agonists JWH015, JWH133, Gp1a, and HU308 controls neuropathic pain and neuroinflammation in animals with chronic retroviral infection. Hind-paw mechanical hypersensitivity in CB2R agonist-treated versus untreated animals was assessed using the MouseMet electronic von Frey system. Multicolor flow cytometry was used to determine the effects of CB2R agonists on macrophage activation and T-lymphocyte infiltration into dorsal root ganglia (DRG) and lumbar spinal cord (LSC). Results demonstrated that, following weekly intraperitoneal injections starting at 5 wk p.i. , JWH015, JWH133, and Gp1a, but not HU308 (5 mg/kg), significantly ameliorated allodynia when assessed 2 h after ligand injection. However, these same agonists (2x/wk) did not display antiallodynic effects when mechanical sensitivity was assessed 24 h after ligand injection. Infection-induced macrophage activation and T-cell infiltration into the DRG and LSC were observed at 12 wk p.i. , but this neuroinflammation was not affected by treatment with any CB2R agonist. Activation of JAK/STAT3 has been shown to contribute to development of neuropathic pain in the LSC and pretreatment of primary murine microglia (2 h) with JWH015-, JWH133-, or Gp1a-blocked IFN-gamma-induced phosphorylation of STAT1 and STAT3. Taken together, these data show that CB2R agonists demonstrate acute, but not long-term, antiallodynic effects on retrovirus infection-induced neuropathic pain.
Exercise Intensity Influences Prefrontal Cortex Oxygenation during Cognitive Testing

Activation changes in the prefrontal cortex (PFC) regions have been linked to acute exercise-induced improvements in cognitive performance. The type of exercise performed may influence PFC activation, and further impact cognitive function. The present study aimed to compare PFC activation during cognitive testing after moderate-intensity, high intensity, and yoga exercises, and to determine if PFC activation is linked to cognitive performance. Eight subjects (four male and four female), aged 35 ± 5 completed a control, high intensity, moderate intensity, and yoga exercises followed by administration of a cognitive task (NIH Toolbox Fluid Cognition). Left and right PFC activation (LPFC and RPFC, respectively) were evaluated by measuring hemoglobin difference (Hbdiff) changes during post-exercise cognitive assessment using functional near infrared spectroscopy (fNIRS). Activation during the cognitive test was higher in the LPFC after moderate intensity exercise compared to control, high intensity, and yoga (5.30 ± 6.65 vs. 2.26 ± 2.40, 2.50 ± 1.48, 2.41 ± 2.36 μM, p < 0.05, respectively). A negative relationship was detected between LPFC and processing speed after exercise. PFC activation did not align with cognitive performance. However, acute exercise, regardless of type, appeared to alter neural processing. Specifically, less PFC activation was required for a given neural output after exercise.
Differences of Expression of PD-L1 in lung adenocarcinoma and lung squamous cell carcinoma

Background : Most patients with NSCLC are diagnosed in advanced stage. Several investigators evaluated the possibility to modulate the immune system for treating lung cancer. PD-L1 expression on tumour cells leads to the inhibition of immune responses against cancer. The aim of this study is to differentiate expression PD-L1 in lung adenocarcinoma and lung squamous cell carcinoma. Materials and Methods : We obtained 40 paraffin blocks of the lung adenocarcinoma and squamous cell carcinoma tumor specimens and assessed PD-L1 expression by immunohistochemistry. Clinicopathological characteristics of the patients were taken from the medical reports in Haji Adam Malik General hospital. Results were analyzed using H-Score to cut-off values of ≥ 30%. Results : in our study we found PD-L1 expression was significantly higher in lung squamous cell carcinoma and in advanced stage.
A Case Report of Pseudohypoglycemia in a Patient with Leukocytosis

A 65-year-old male with a history of gout was admitted for evaluation of hematuria. Labs during his admission revealed a venous blood glucose of 43mg/dl. Point of care glucose checks were not ordered on admission as the patient was not diabetic. The patient was fully alert and oriented with no somnolence, diaphoresis or palpitations. He was not taking any antihyperglycemic medications at home, and he had an HbA1c of 6.2%. He was hemodynamically stable with no signs of infection. The only other lab abnormality noted was a leukocytosis of 95,000/μL. Point of care glucose checks were ordered with meals and at bedtime. A subsequent venous blood glucose was 27mg/dL, but the patient remained asymptomatic and a simultaneous point of care glucose was 92mg/dL. A close evaluation of the case revealed a delay between phlebotomy time and processing of the venous sample. Immediate processing of the following venous sample revealed a normal glucose (90mg/dL) that correlated with the simultaneous point of care glucose. Repeat testing with quick processing of the sample clarified that the measurements of low venous blood glucose levels were due to in vitro glucose consumption by leukocytes that occurred between the times of phlebotomy and sample analysis.
Exploring Different Types Of Treatment Of Obstructive Sleep Apnea Syndrome: A Review

Obstructive sleep apnea syndrome (OSAS) is a complete or partial airway obstruction that can cause significant impacts on patientâ€2s life in aspects as craniofacial diseases, cognitive performance and quality of life. The variety of intervention for treatment of pediatric obstructive sleep apnea syndrome are complex, varied and multidisciplinary. They include: lifestyle changes (as weight reduction programs, adequate sleep hygiene and alteration of the sleeping p o s i t i o n ) , s u r g i c a l a p p r o a c h e s (adenotonsillectomytracheostomy for tube placement, m a x i l l o m a n d i b u l a r a d v a n c e m e n t , uvulopalatopharyngoplasty and others) and non surgical approaches (CPAP, continuous positive airways pressure, oral appliances, rapid maxillary expansion, and anti inflammatory treatments). From this review it can conclude that not all patients with OSAS find benefit from the same therapy, due to the complex relationship between anatomical factors and neuromuscular mechanism at the base of this syndrome. A multidisciplinary approach involving o r t h o d o n t i s t s a t t h e s a m e l e v e l a s otorhinolaryngologist and pediatric specialists in the diagnosis and treatment of OSAS in children is fundamental to recognize which type of treatment may be the best for each patient.