Miracle-dz/UniFAR-FTUs huggingface dataset:
Relation of maternal CMV viremia and antibody response to the rate of congenital infection and intrauterine growth retardation

Pregnancy outcome after maternal primary CMV infection initiated at different times during gestation was investigated by using the inbred Strain‐2 guinea pig model of congenital CMV infection. The highest vertical transmission rates occurred in pups from dams that were initially viremic in late gestation presumably because delivery occurred prior to detectable maternal CMV‐specific immune response. In contrast, conceptus loss was highest with maternal CMV infection initiated at conception. Intrauterine resorptions, intrauterine growth retardation, and disseminated neonatal CMV infection with CNS involvement were more frequent in pups born to mothers that were initially viremic prior to rather than after midgestation. Maternal viremia was prolonged and antibody responses were delayed after CMV inoculation in early gestation compared to late gestation. Prolonged maternal viremia plus early gestational virus exposure/infection of the fetus appeared to be associated with the most severe outcome. These findings suggest that the timing of initial maternal viremia and immune responses, the stage of fetal development, and the length of in utero exposure to CMV are important factors in subsequent disease expression and rates of congenital infection.
Are you really doing good things in your boss's eyes? Interactive effects of employee innovative work behavior and leader–member exchange on supervisory performance ratings

Organizations increasingly depend on employee efforts to innovate. However, the quality of relationships between leaders and employees may affect the recognition that employees receive for their innovative work behaviors. Drawing from a social cognition perspective, we tested a model in which leader–member exchange (LMX) moderates the impact of employee innovative work behavior on supervisory ratings of employee performance. Results from two multisource studies combining self, colleague, and supervisor ratings consistently showed that employees receive more favorable performance ratings by engaging in innovative work behavior when they have high-quality LMX relationships. Moreover, we found that this interactive relationship was mediated by leader perceptions of innovative employee efforts, providing support for a moderated mediation model. Implications for the literatures on performance appraisal, LMX, and innovation are discussed.
Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina.

BACKGROUND Acute coronary ischemia is usually initiated by rupture of atherosclerotic plaque, leading to intracoronary thrombosis and clinical sequelae. The proximate cause of plaque rupture is unknown. Accordingly, we investigated the potential role of the 92-kD gelatinase member of the matrix metalloproteinase family in acute coronary ischemia. METHODS AND RESULTS Coronary atherectomy specimens from patients with atherosclerosis and an acute ischemic syndrome consistent with recent plaque rupture (unstable angina) (n = 12) were immunostained for the presence of 92-kD gelatinase; the results were compared with those obtained by identical study of atherectomy specimens from patients with atherosclerosis and angina but without acute ischemia (stable angina) (n = 12). Positive immunostaining for 92-kD gelatinase was present in 83% of specimens from both unstable and stable angina patients. However, intracellular localization of enzyme (indicating active synthesis) was documented in 10 of 10 positively stained specimens from patients with unstable angina compared with 3 of 10 positively stained specimens from patients with stable angina. Macrophages and smooth muscle cells were the major sources of 92-kD gelatinase in all specimens examined by immunostaining of adjacent sections. CONCLUSIONS 92-kD gelatinase is commonly expressed in coronary arterial atherosclerotic lesions. Active synthesis of 92-kD gelatinase by macrophages and smooth muscle cells in atherosclerotic lesions may play a pathogenic role in the development of acute coronary ischemia.
Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice

Dopaminergic systems are thought to mediate the rewarding and reinforcing effects of palatable food. However, the relative contribution of different dopamine receptor subtypes is not clear. We used dopamine D1 receptor deficient mice (D^{\,‐/‐}_{1}) and their wild‐type and heterozygous littermates to study the role of the D1 receptor in palatable food reinforced behaviour using operant responding and free access paradigms. Non‐deprived mice were trained to press a lever for sucrose pellets under three schedules of reinforcement including fixed ratios (FR‐1 and FR‐4) and a progressive ratio (PR). Responding on one lever was reinforced by the delivery of a sucrose pellet or solution while responding on a second lever had no programmed consequences. Initially, D1 mutant mice took longer to learn to discriminate between the two levers and had significantly lower operant responding for sucrose pellets and solution than wild‐type and heterozygous mice under all schedules of reinforcement. Food deprivation enhanced responding on the active lever in all mice although it remained significantly lower in D^{\,‐/‐}_{1} mice than in control mice. Following extinction of sucrose reinforcement and reversal of the levers, D^{\,‐/‐}_{1} mice showed deficits in extinguishing and reversing previously learned responses. Home cage intake and preference of sucrose pellets and solutions when given under free‐choice access paradigms were similar among the groups.
Fusing games technology and pedagogy for games-based learning through a model driven approach

Computer games have been closely linked to learning in recent years through the educational potential of game-based learning. Many believe that it is now appropriate to adopt this innovative approach to motivate the current generation of learners in regaining their interest in learning certain topics. However, this approach is impeded by the limited availability of ‘serious’ games. Developments in software engineering that enable automatic generation of software artefacts through diagrams and modelling techniques promises a new hope for game-based learning adopters, especially those with little or no technical knowledge, to produce their own serious games for use in game-based learning. This paper describes our model-driven approach designed to aid non-technical domain experts in the production of serious games.
Integrated Economic and Financial Analysis of China’s Sponge City Program for Water-resilient Urban Development

To improve Chinese cities’ resilience to climate change, the Sponge City Program, which was designed to tackle water pollution, storm water management, and flooding, was initiated in 2014. Being a major policy initiative, the Sponge City Program raises heated discussions among Chinese academics; however, no relevant extensive economic or financial analysis has been conducted. The research carries out an integrated economic and financial analysis on the Sponge City Program from the perspectives of two stakeholders: the government and the project manager. Different stakeholders have unique perspectives on the management of water projects. This study has two parts: economic analysis and financial analysis. The economic analysis is from the government perspective, and considers all the economic, environmental, and social effects. The financial analysis is from the project manager’s perspective, and judges the financial feasibility of projects. Changde city, one of the demo cities of Sponge City Program, is chosen for the research. The results show that from the perspective of the government, the Sponge City Program should be promoted, because most water projects are economically feasible. From the perspective of the project manager, the program should not be invested in, because the water projects are financially infeasible. A more comprehensive and integrated plan for developing and managing the water projects of the Sponge City Program is required. Otherwise, the private sector may not be interested in investing in the water projects, and the water projects may not be operational in the long term.
Color Doppler Imaging of Ocular Blood Flow after Topical Ketanserin

The authors investigated the effect of ketanserin 0.5% eye drops on intraocular pressure and orbital blood flow in some healthy volunteers. Ketanserin is a selective antagonist of serotonin S2 receptors; moreover, it produces an α1-blocking effect. It causes a systemic reduction of blood pressure and capillary vasodilatation. Three hours after topical administration of ketanserin 0.5%, the intraocular pressure was decreased by about 14% from the baseline. At the same time, we observed by color Doppler imaging that the mean percent increase in the peak systolic velocity in the ophthalmic artery (OA) was 5.18% (p < 0.161) and 23.18% (p < 0.001) in the posterior ciliary arteries (PCAs). The mean resistance index of the OA was in contrast reduced by 1.16% (p < 0.669) and by 32.14% (p < 0.003) in the PCAs. These data show that ketanserin 0.5% eye drops may be useful not only to decrease intraocular pressure but also to improve blood flow in the PCAs that supply the optic nerve head.
Chaotic Oscillations in a CMOS Inverter Coupled With ESD Protection Circuits Under Radio Wave Excitation

This study demonstrates the presence of chaotic oscillations in standard CMOS circuits. At radio-frequencies, ordinary digital circuits can show unexpected nonlinear responses. We examine a CMOS inverter coupled with electrostatic discharging (ESD) protection circuits, designed with 0.35 μm CMOS technology, for evidence of its chaotic oscillations. As the circuit is directly driven by a radio-frequency signal, the circuit enters a chaotic dynamic regime when the input frequency is higher than the maximum operating frequency of CMOS inverter. We observe an aperiodic signal, a broadband spectrum, and a complex spectrum. We discuss the nonlinear physical effects in the given circuit: ESD diode rectification, dc bias shift due to a nonquasi-static regime operation of the ESD PN-junction diode, and a nonlinear resonant feedback current path. In order to predict these chaotic dynamics, we develop a transistor-based model, and compare it with the experimental results. To verify the presence of chaotic oscillations mathematically, we develop an ordinary differential equation model with the circuit-related nonlinearities. The largest Lyapunov exponents are calculated to verify the chaotic oscillations. The importance of this study derives from investigating chaotic oscillations in standard CMOS circuits as circuit-effects due to high-intensity electromagnetic signals.
Self-tuning Fuzzy PI scheme for DTC Induction Motor drive

In this paper, a robust self-tuning fuzzy speed controller for direct torque control using space vector modulation (SVM) technique is proposed for the high performance drives of induction motor. The design of robust self-tuning fuzzy speed controller greatly affects the performance of Induction Motor (IM) fed with a Voltage Source Inverter (VSI). The performance of the proposed self-tuning Fuzzy PI controller is compared with the corresponding fuzzy logic controller and PI controller. The performance index based on speed error is assigned to provide a numerical comparison among different controllers. When compared with other methods, the torque ripples are reduced remarkably with the proposed method. Simulation results verify the validity of the proposed method.
Fluconazole-Resistant Candida albicans Vulvovaginitis

OBJECTIVE: As a result of high recurrence rates of Candida albicans vaginitis, successful suppressive fluconazole is widely used, and drug resistance is considered rare. We report increased occurrence of secondary fluconazole resistance, analysis of risk factors thereof, and describe management of fluconazole-refractory vaginitis. METHODS: Patients referred to the Vaginitis Clinic at Wayne State University with clinically refractory fluconazole-resistant (minimum inhibitory concentration [MIC] 2 micrograms/mL or greater) C albicans vaginitis from 2000 to 2010 were enrolled. Patients completed a questionnaire pertaining to demographics, comorbidities, behavioral characteristics, exposure to antimicrobials and antifungals, fluconazole consumption in defined daily doses in the previous 6 months, management received, and outcomes. With patients not located, data were extracted from charts. Susceptibilities to antifungals were determined by broth microdilution. RESULTS: Twenty-five women with fluconazole-resistant recurrent C albicans vaginitis were identified, and 16 returned filled questionnaires. Study cohort consisted mainly of married, insured white women with more than 12 years of formal education and average or above average socioeconomic status. Median fluconazole MIC was 8 micrograms/mL (range 2–128 micrograms/mL). Risk factors for mycologic failure included increased fluconazole consumption (P=.03) with 16 of 25 women exposed to low-dose weekly fluconazole maintenance therapy. All patients were clinically controlled successfully, although treatment was difficult and often prolonged. CONCLUSION: Fluconazole-resistant C albicans vaginitis was previously considered rare. We report 25 cases over an 11-year period, indicating an emerging problem. All patients had fluconazole consumption in the previous 6 months. Management of fluconazole refractory disease is extremely difficult with limited options, and new therapeutic modalities are needed. LEVEL OF EVIDENCE: II
Teachers’ Knowledge on Education for Sustainable Development – Polish Context/Znanje nastavnika o obrazovanju za održivi razvoj – slučaj Poljske

Abstract The sustainable development model is considered to be the only one implementing the postulate of intra- and intergenerational justice, and allowing modern societies to develop safely. Because education makes it possible to achieve complex social goals, the sustainable development model must be implemented in a modern school. For this purpose, UNESCO experts promote education for sustainable development (ESD) as a response to the challenges of the modern world. The article presents the results of empirical research on teacher knowledge on education for sustainable development. Participants in the research, which was carried out in 2016, were 337 Polish teachers of the lower and upper secondary school. The research analysis showed that Polish teachers are not properly prepared for the implementation of assumptions of education for sustainable development into education programmes - their knowledge in this area is insufficient. Key words: education for sustainable development; school; shaping competencies; sustainability; teacher. --- Sažetak Smatra se da je model održivoga razvoja jedini model koji primjenjuje postulat unutar i međugeneracijske pravednosti te omogucuje siguran razvoj suvremenoga drustva. S obzirom na to da obrazovanje omogucuje stjecanje složenih drustvenih ciljeva, model održivoga razvoja mora biti primijenjen i u suvremenim skolama. S tom svrhom strucnjaci UNESCO-a promoviraju obrazovanje za održivi razvoj (OOR) kao odgovor na izazove suvremenoga svijeta. Rad donosi rezultate empirijskoga istraživanja o znanju nastavnika o obrazovanju za održivi razvoj. U istraživanju koje je provedeno 2016. sudjelovalo je 337 nastavnika nižih i visih razreda srednje skole. Analiza rezultata pokazala je da su poljski nastavnici nedovoljno pripremljeni za provedbu teza iz podrucja obrazovanja za održivi razvoj u obrazovne programe – njihovo znanje iz spomenutoga podrucja je nedostatno. Kljucne rijeci: nastavnik; oblikovanje kompetencija; obrazovanje za održivi razvoj; održivost; skola.
Inclusion of Corporate Social Responsibility As a Module in University Syllabi: A Study of Contents, Pedagogies and Academia-Industry Initiatives in Nepal

The paper performs a probe into the coverage of corporate social responsibility (CSR) as a module in university syllabi in Nepal by exploring the existing CSR contents and pedagogy in the business school curricula as well as academiaindustry linkages to promote CSR education in the country. Since the issue of CSR and business ethics has the direct bearing on business and management domain, the paper has explored the syllabi of business schools. The study— based on a descriptive approach—sought to draw out a perspective on the content and pedagogy of the BE and CSR module in Nepali varsities. Encompassing the existing Nepali universities and/or the business schools under their fold, the study discovered that Tribhuvan University, the only central and national university of Nepal, has offered more BE and CSR contents either as a separate, independent module or as an integral part of other related subjects in a larger number of bachelors and masters programmes. Yet, there is a need to specify and ameliorate pedagogical arrangements in most of the universities in Nepal. Since BE and CSR are relatively young modules, the findings should prove instrumental for Nepali universities to formulation of curricular plans and strategies vis-à-vis foreign business schools in the days to come.
Canada's Carbon Price Floor

The pan-Canadian approach to carbon pricing, announced in October 2016, ensures that carbon pricing applies throughout Canada in 2018, with increasing stringency over time to reduce emissions. Canadian provinces and territories have the flexibility to either implement an explicit price-based system—with a minimum price of CAN $10 per tonne of carbon dioxide equivalent in 2018, increasing to CAN $50 per tonne by 2022—or an equivalently scaled emissions trading system. This paper discusses the rationale for, and design of, the price floor requirement; its (provincial-level) environmental, fiscal, and economic welfare impacts; monitoring issues; and (national-level) incidence. The general conclusion is that the welfare costs and implementation issues are manageable, and pricing provides significant new revenues. A challenge is that the floor price by itself appears well short of what will be needed by 2030 for Canada’s Paris Agreement pledge.
Failure of influenza vaccination in the aged

A cohort of 127 nursing home residents aged 60–98 years were vaccinated during the winter of 1985–86 with the A‐Chile 1/83 (C), A‐Philippines 2/82 (P), and B‐USSR (B) commercial influenza vaccines. Before vaccination 40%, 23%, and 69% were susceptible to influenza Ac, Ap, and B, respectively [hemagglutinin inhibition (H.I.) titer <1:40]. One month following initial vaccination, 32 patients [25%] remained unprotected against two or all three vaccine strains. These patients were revaccinated with the same influenza vaccine and followed up. At five months 11 %, 19%, and 23% of the initial cohort were still unprotected against Ac, Ap, and B strains, respectively. We conclude that two conventional influenza vaccines administered one month apart leave unprotected 30% of healthy elderly people who are initial influenza vaccine failures.
Structure, Biosynthesis, and Physicochemical Properties of Archaebacterial Lipids

A series of recent phylogenetic studies, based on 16S ribosomal ribonucleic acid (RNA) composition (2, 33, 84, 104, 105) and other general biochemical features (33, 105) such as RNA polymerase (71, 81, 86, 113, 116), translation system (10, 54, 55, 80, 85), transfer RNA (44, 56, 58, 59), 5S ribosomal RNA (32, 69, 70), cell wall (21, 50-52, 77, 84, 103), and lipids (25, 26, 28, 53, 60, 67, 72, 98), reveals the existence of a new group of microorganisms named archaebacteria. Some features, e.g., their small size and structural simplicity, the absence of a nuclear membrane and organelles, and low deoxyribonucleic acid content, indicate that archaebacteria are procaryotic (33, 84, 105). In contrast, it has been proposed that archaebacteria are closely related to the ancestor eucaryotes (79, 100) since several characteristics, such as the presence of histone-like proteins (42, 87, 96), the nature of their translation system (54, 55, 85), and the sequence of their 5S RNA (46) and that of ribosomal proteins (73), are considered to be typical of eucaryotes. This body of results leads us to consider that archaebacteria are as far from eubacteria as they are from eucaryotes (103). Archaebacteria are quite interesting microorganisms from the point of view of the early evolution of life; indeed, their name was given to underline the hypothesis that these organisms were the dominant inhabitants of the earth in early ancient times (2, 33, 104, 105). In this respect, archaebacteria, as a distinct primary kingdom, are very important as they give us some indications of the early events in the evolution of cells, thus contributing to a better understanding of the universal ancestor. Archaebacteria are characterized by a wide metabolic diversity and a high degree of morphological variability that is roughly comparable to that found in eubacteria. In fact, this group includes aerobes, anaerobes, autotrophs, heterotrophs, thermophiles, acidophiles, phototrophs, cocci, rods, and disk-shaped and pleiomorphic forms (1, 6, 7, 9, 16, 22, 49, 74, 77, 83, 93, 104, 105, 111, 112, 114, 115). Archaebacteria are classified into three major phenotypes;
The relationship among depression, subjective cognitive impairment, and neuropsychological performance in multiple sclerosis

The aim of this study was to examine, within the context of a treatment study, the relative contributions of depression and neuropsychological performance on patient ratings of cognitive functioning in a cohort of 58 moderately-depressed multiple sclerosis (MS) patients. All participants were randomized to one of three 16-week conventional treatments for depression. Assessments were conducted pre and post-treatment using: (1) Cognitive Function subscale of the Multiple Sclerosis Quality of Life-54 (MSQOL-54) to evaluate subjective cognitive impairment (SC), (2) Beck Depression Inventory (BDI), and (3) a neuropsychological index score (NP). Prior to treatment, 8% of the variance in SC was explained by NP, whereas 14% of the variance was explained by BDI, above and beyond NP. At post-treatment, patients were classified as ‘responders’ (BDI<11) and ‘nonresponders’ (BDI≥11). Among those participants classified as ‘responders’, NP accounted for 39% of the variance in SC, and BDI did not significantly predict SC. The results of this study suggest that depression may influence subjective reports of cognitive impairment, but these reports may not be reliably related to objective neuropsychological performance. Furthermore, patients may be more accurate reporters of their cognitive impairment after successful treatment for depression, suggesting that depression decreases the accuracy of patient reported cognitive impairment.