Miracle-dz/UniFAR-FTUs huggingface dataset:
No differences in physical activity in (un)diagnosed asthma and healthy controls

To establish whether asthma affects physical activity levels in children (aged 7–10 years) we evaluated physical activity levels in children with undiagnosed asthma (UDA), diagnosed asthma (DA), and healthy controls (HCs). A cross‐sectional community‐based study was performed which included a parental questionnaire on their child's respiratory health, and testing of airway reversibility and bronchial hyperresponsiveness (BHR). DA was defined as the parents' confirmation of a physician's diagnosis of asthma in the past 12 months. UDA was defined by asthma symptoms combined with airway reversibility or BHR in children without a physician's diagnosis of asthma. Physical activity was measured during 5 days with an accelerometer and a diary, and with the habitual activity estimation scale which reviews the physical activity during the past 2 weeks. The final study population comprised 1614 children of whom 81 (5%) had DA, 130 (8%) UDA, and 202 HCs. Baseline FEV1 % was lowest in children with UDA (UDA FEV1 94% predicted, DA FEV1 98% predicted, HCs FEV1 100% predicted). Using the three methods, no differences were found in the physical activity between children with UDA, DA, and HCs. Childhood asthma does not appear to be associated with a decreased level of daily physical activity in our study population. Pediatr Pulmonol. 2007; 42:1018–1023. © 2007 Wiley‐Liss, Inc.
Sodium iodate induced retinal degeneration: new insights from an old model

Studies on the selective retinal degeneration induced by sodium iodate (NaIO3) date back to 1941; Sorsby (1941) described the effect of intravenously injected NaIO3 solution on the rabbit retina. Since then, NaIO3-induced retinal degeneration has been described in different mammalian species including sheep, rabbit, rat and mouse with varying doses and routes of administration. At the present time, the murine NaIO3 model is the most widely used because it results in reproducible, patchy retinal degeneration (Figure 1) and can be studied in a wide variety of wild type and genetic knockout strains. Many studies reporting the pathologic changes in retinal structure at specific time points and electrophysiological changes in retinal function over time have followed (Franco et al., 2009; Redfern et al., 2011). More recently, the model has gained a resurgence of interest because of the ability to utilize high resolution in vivo imaging to study structural changes in the retina in live animals. Techniques such as spectral domain optical coherence tomography (OCT) and confocal scanning laser ophthalmoscopy (cSLO) allow longitudinal evaluation of retinal structure (Machalinska et al., 2014; Yang et al., 2014); thus making this model amenable to evaluation of novel therapeutic approaches to retinal degeneration such as cellular therapies.
Abnormal modulation of amygdala activity in schizophrenia in response to direct- and averted-gaze threat-related facial expressions.

OBJECTIVE Reduced amygdala activation in individuals with schizophrenia is thought to contribute to impairments in emotion recognition and social functioning. Recent work, however, suggests that amygdala abnormalities in schizophrenia are more nuanced than generalized hypoactivation and that modulation of amygdala responses across different stimulus types may be more closely related to social functioning than to overall levels of amygdala activation during a task. The authors investigated amygdala modulation during emotion recognition in patients by manipulating the gaze direction of threat-related expressions. METHOD Blood-oxygen-level-dependent functional MRI was used to measure neural activation in 37 healthy volunteers and 35 schizophrenia patients while participants identified the emotion (anger or fear) displayed on facial stimuli that appeared with either direct or averted gaze. RESULTS Analysis of percent signal change in the amygdala bilaterally revealed a three-way interaction of emotion, gaze, and group, demonstrating significantly reduced amygdala responses to direct-gaze anger expressions in the patient group but comparable levels of activation across groups in all other conditions. Within the patient group, amygdala responses to direct-gaze anger expressions were positively correlated with level of functioning. CONCLUSIONS These findings extend previous reports of amygdala hypoactivation in schizophrenia by identifying abnormal amygdala modulation in response to varying emotional stimuli. Additionally, the strong relationship between amygdala activation and social and occupational functioning underscores the need for investigations of amygdala modulation in schizophrenia that further specify the nature of these impairments and that examine a potential causal link between amygdala activation and functioning.
The effect of nurses' use of the principles of learning organization on organizational effectiveness.

AIM This paper is a report of a study to describe the effect on organizational effectiveness of nurses' use of the principles of learning organization. BACKGROUND Since Senge proposed the learning organization model in 1990, the principles of learning organization have been considered as a new organizational vision. However, there is little empirical evidence that shows how nurses' use of the principles of learning organization affects organizational effectiveness in healthcare settings. METHOD A cross-sectional survey was used and the data were collected in 2003. Participants were 629 professional nurses who had worked full-time for more than 1 year in the general units of nine tertiary medical hospitals in South Korea. A questionnaire was distributed to nurse managers of nine hospitals, who distributed it to 665 nurses, 635 of whom responded (response rate 95.5%). Six returns were discarded due to incomplete responses, leaving 629 for data analysis. RESULTS There was a statistically significant positive relationship between nurses' use of the principles of learning organization and organizational effectiveness. Hierarchical multiple regression analysis revealed that the concept explained an additional 24.9% of organizational commitment and a further 22.6% of job satisfaction. The learning organization principles of shared vision and team learning were statistically significant predictors for organizational effectiveness. CONCLUSION Individual nurses can use the principles of learning organization to enhance organizational effectiveness. Intervention programmes that integrate and strengthen shared vision and team learning may be useful to enhance organizational effectiveness. Further research is required to identify other factors related to the principles of learning organization.
Breast and Cervical Cancer Related Practices of Female Doctors and Nurses Working at a University Hospital in Turkey.

BACKGROUND Breast and cervical cancers are among the most frequent and most fatal cancers in women. Life span of patients may be increased and quality of life improved through early diagnosis and treatment. This investigation was performed in order to determine knowledge and practices of female health personnel working at a university hospital regarding breast and cervical cancers. MATERIALS AND METHODS This descriptive investigation was performed in Erciyes University Hospitals in 2014. A total of 524 female health personnel were included in the study. Data were collected through a questionnaire of 36 questions prepared by the researchers. The Chi square test and logistic regression were used for statistical analyses. RESULTS The mean age of the study group was 32.8±6.9 years, 18.3% being doctors and 81.7% nurses. Of the study group, 60.5% stated that they performed self breast-examination, 4.4% underwent HPV testing, 26.3% thought about taking an HPV test, 34.7% of those who are 40 years and over had mammography regularly and 19.5% of those who were married had a Pap smear conducted regularly. Most important causes of not performing the methods for early diagnosis of breast and cervical cancers are "forget and neglect". CONCLUSIONS It was concluded that female doctors and nurses do not pay sufficient attention to screening programs for breast and cervical cancers. The importance of early diagnosis and treatment should be emphasized during the undergraduate education and in-service training programs. Health condition of personnel and their utilization of preventive health care should be followed by occupational physicians.
Sustaining delivery of the first publicly reimbursed cognitive service in Denmark: a cross‐case analysis

Objectives The aim was to identify local organisational factors that affect sustained delivery of the first Danish publicly reimbursed cognitive service, the Inhaler Technique Assessment Service (ITAS). The ITAS is a 10‐min interactive counselling session during which pharmacy staff assess the inhalation technique of individual asthma patients at the pharmacy counter, and correct any errors. Knowledge of how the organisation of a local pharmacy influences ITAS provision will be used to develop quality indicators as part of a targeted quality‐assurance system to support the sustainability of the service in all Danish community pharmacies.
Effect of alcohol on drug efflux protein and drug metabolic enzymes in U937 macrophages.

BACKGROUND ATP-binding cassette (ABC) proteins and cytochrome P450 (CYP) enzymes regulate the bioavailability of HIV-1 antiretroviral therapeutic drugs, non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs). They are also involved in regulating, and responding to, oxidative stress in various tissues and organs including liver. This study is designed to assess the effect of alcohol on the ABCC1 and CYP enzymes involved in the metabolism of NNRTIs and PIs (CYP2B6, CYP2D6, and CYP3A4) and oxidative stress (CYP1A1, CYP2A6, and CYP2E1) in U937 macrophages. The U937 cell line has been utilized as an in vitro model of human macrophages. METHODS The expression levels of the ABCC1 and CYP enzymes in U937 macrophages were characterized in terms of mRNA quantification, protein analysis, and assays for functional activity. In addition, oxidative stress was monitored by measuring the activities of oxidative stress marker enzymes and production of reactive oxygen species (ROS). RESULTS The order of mRNA expression in U937 macrophages was ABCC1 ∼ CYP2A6 > CYP3A4 ∼ CYP2E1 ∼ CYP1A1 > CYP2D6 > CYP2B6. Alcohol (100 mM) increased the mRNA levels of ABCC1 and CYP2A6 (200%), CYP2B6 and CYP3A4 (150%), and CYP2E1 (400%) compared with the control. Alcohol caused significant upregulation of ABCC1, CYP2A6, CYP2E1, and CYP3A4 proteins (50 to 85%) and showed >50% increase in the specific activity of CYP2A6 and CYP3A4 in U937 macrophages. Furthermore, alcohol increased the production of ROS and significantly enhanced the activity of oxidative stress marker enzymes, superoxide dismutase, and catalase in U937 macrophages. CONCLUSIONS Our study showed that alcohol causes increases in the genetic and functional expressions of ABCC1 and CYP enzymes in U937 macrophages. This study has clinical implications in alcoholic HIV-1 individuals, because alcohol consumption is reported to reduce the therapeutic efficacy of NNRTIs and PIs and increases oxidative stress.
Effective Instruction for English Learners

The fastest-growing student population in U.S. schools today is children of immigrants, half of whom do not speak English fluently and are thus labeled English learners. Although the federal government requires school districts to provide services to English learners, it offers states no policies to follow in identifying, assessing, placing, or instructing them. Margarita Calderón, Robert Slavin, and Marta Sánchez identify the elements of effective instruction and review a variety of successful program models.During 2007-08, more than 5.3 million English learners made up 10.6 percent of the nation's K-12 public school enrollment. Wide and persistent achievement disparities between these English learners and English-proficient students show clearly, say the authors, that schools must address the language, literacy, and academic needs of English learners more effectively.Researchers have fiercely debated the merits of bilingual and English-only reading instruction. In elementary schools, English learners commonly receive thirty minutes of English as a Second Language (ESL) instruction but attend general education classes for the rest of the day, usually with teachers who are unprepared to teach them. Though English learners have strikingly diverse levels of skills, in high school they are typically lumped together, with one teacher to address their widely varying needs. These in-school factors contribute to the achievement disparities.Based on the studies presented here, Calderón, Slavin, and Sánchez assert that the quality of instruction is what matters most in educating English learners. They highlight comprehensive reform models, as well as individual components of these models: school structures and leadership; language and literacy instruction; integration of language, literacy, and content instruction in secondary schools; cooperative learning; professional development; parent and family support teams; tutoring; and monitoring implementation and outcomes. As larger numbers of English learners reach America's schools, K-12 general education teachers are discovering the need to learn how to teach these students. Schools must improve the skills of all educators through comprehensive professional development—an ambitious but necessary undertaking that requires appropriate funding.
Speakers' Sex Differences in Voice Onset Time: A Study of Isolated Word Production

This report presents a brief study into sex differences of speakers in the voice onset time of English plosives that are stressed in both word-initial and pre-vocalic positions. 36 isolated words were spoken by 5 men (age range 25 to 37 yr., M: 34.2 yr.) and 5 women speakers (age range 28 to 38 yr., M: 32.6 yr.) who were subjects. Analysis showed that the women speakers had on the average relative to the men, longer voice onset time values for voiceless plosives and shorter voice onset time values for the voiced plosives.
Suppression of Parasite‐Specific Response in Plasmodium falciparum Malaria. A Longitudinal Study of Blood Mononculear Cell Proliferation and Subset Composition

The present longitudinal study was designed to characterize immunosuppression during acute Plasmodiu, falciparum infection, during the treatment and up to 1 month after the acute stage. The proliferative responses of blood mononuclear cells (BMNC) isolated from non‐immune and semi‐immune malaria patients and controls to mitogens and two Plasmodium‐derived stimulators (merozoites, Meroz. and soluble purified antigen, Spag) and non‐related antigens were measured by [2 H]thymidine incorporation. BMNC isolated before treatment (day 0) from the non‐immune patients did not respond to Meroz, whereas those from controls showed a significantly higher response. The SPag responses were also low in BMNC isolated on day 0 and increased in both the non‐immune and the semi‐immune patients during the observation period. These findings indicate that during malaria there is a depression of the parasite‐specific proliferative response. The subset composition of BMNC isolated from non‐immune patients was studied in a FACS analyser. The mean cell volumes of both Leu 2’and Leu.3 cells were increased during the acute phase of the infection, indicating that malaria infection results in activation of both T‐helper and T‐suppressor cells. There was no overall reduction of the response to mitogens on day 0. However. 3 days alter initiation of the treatment the mitogen response was decreased. ‘This finding indicates that it is important to distinguish between the effects of malaria infection and of drug treatment.
Lumbar disc degeneration: association between osteophytes, end-plate sclerosis and disc space narrowing

Background: Lumbar disc degeneration is characterised radiologically by the presence of osteophytes, end-plate sclerosis and disc space narrowing. Aim: To determine the strength of the association between increasing severity of combinations of these features in a population sample of men and women. Methods: Men and women aged ⩾50 years were recruited from a primary care-based community health index in Aberdeen, UK. Participants had lateral spinal radiographs performed according to a standard protocol. The intervertebral disc spaces (L1/2–L4/5) were evaluated for the presence of anterior osteophytes, end-plate sclerosis and disc space narrowing using a graded semiquantitative score (grade 0–3). Log linear modelling was used to determine the associations (pairwise) between increasing severity of these features, with the results expressed as β coefficients and 95% confidence intervals (CIs). Results: There were 286 men (mean age 65.3 years) and 299 women (mean age 65.2 years) with spinal radiographs, yielding a total of 2340 assessable lumbar vertebral levels. In all, 73% of vertebral levels had evidence of osteophytes, 26% of sclerosis and 37% of disc space narrowing. Increasing severity of osteophyte grade was associated with an increasing severity both of sclerosis and of disc space narrowing, whereas the severity of sclerosis was associated with the severity of narrowing. This was true at all vertebral levels. The strongest association, however, was between osteophytes and sclerosis (β coefficient = 2.7, 95% CI 2.4 to 3.1). For sclerosis and narrowing the β coefficient was 1.9 (95% CI 1.7 to 2.1), whereas for osteophytes and narrowing the β coefficient was much weaker at 1.2 (95% CI 1.1 to 1.3). There was no important influence of vertebral level on any of these associations. Conclusion: The association between increasing severity of osteophytes and end-plate sclerosis is stronger than for other combinations of radiographic features of lumbar disc degeneration.
Navigation Behavior Selection Using Generalized Stochastic Petri Nets for a Service Robot

Appropriate design and control of behaviors of mobile robots are important for their successful autonomous navigation in a real dynamic environment. This paper proposes a formal selection framework of multiple navigation behaviors for a service robot. In the presented approach, modeling, analysis, and performance evaluation are carried out based on generalized stochastic Petri nets (GSPNs). By adopting a probabilistic approach, the proposed framework helps the robot to select the most desirable navigation behavior in run time according to environmental conditions. Moreover, after mission completion, the robot evaluates its prior navigation performance from accumulated data, and automatically uses the results to improve its future operations. Also, GSPNs have several advantages over direct use of other modeling formalisms such as finite state automata (FSA) or Markov processes (MPs). We conduct experiments on real guidance tasks with visitors by implementing the framework in the guide robot Jinny at the National Science Museum of Korea. The results show that the proposed strategy is useful for a robot's selection of an appropriate navigation behavior in a dynamic environment.
The View of Constructivist Theory on Assessment: Alternative Assessment Methods in Education

Since the Ministry of National Education started the structural changes in the primary and secondary education curricula, there has been a growing interest towards constructivist learning philosophy, constructivist theory and active learning in educational and scientific environments in Turkey. Alternative assessment practices have an important place in the new curricula, which went into effect in 2005-2006 academic year. Many authors suggest that objectives for active learning method could only be attained if they were used together with alternative assessment practices. There are many writers who suggest that objectives for active learning method could only be reached if they were used together with alternative assessment activities. The principal aim of this study is to analyze the relations between constructivism and learning and assessment and also to discuss theoretically portfolio assessment and peer-self-co-assessment approaches that have emerged, and additionally to determine the positive and negative results stated in related studies, so that practitioners could draw some deductions.
GROWTH HORMONE RESPONSE TO FEEDING IN TERM AND PRETERM NEONATES

ABSTRACT. Plasma growth hormone concentrations were measured in 248 healthy term and preterm infants. At birth growth hormone concentrations in cord blood from both term and preterm babies were approximately 100‐fold higher than those in blood drawn from healthy adults. By the sixth postnatal day basal pre‐feed levels had fallen in term neonates by 65% and a marked postprandial rise was apparent; preterm infants did not show this initial fall in preprandial hormone levels nor was any response to feeding seen. However a fall in preprandial concentrations accompanied by the development of postprandial surges in growth hormone occurred during the next 2 weeks so that by 24 days the postprandial rise was similar to that of term neonates on the sixth day. We conclude that although the initial postnatal changes in plasma growth hormone concentrations are different in preterm and term infants, feeding is a major stimulus to growth hormone secretion in both groups of neonates. Further work is needed to define the precise role of this hormone in neonatal metabolic adaptation.
Fluid Petri Nets for the Performance Evaluation of MapReduce and Spark Applications

Big Data applications allow to successfully analyze large amounts of data not necessarily structured, though at the same time they present new challenges. For example, predicting the performance of frameworks such as Hadoop and Spark can be a costly task, hence the necessity to provide models that can be a valuable support for designers and developers. Big Data systems are becoming a central force in society and the use of models can also enable the development of intelligent systems providing Quality of Service (QoS) guarantees to their users through runtime system reconfiguration. This paper provides a new contribution in studying a novel modeling approach based on fluid Petri nets to predict MapReduce and Spark applications execution time which is suitable for runtime performance prediction. Models have been validated by an extensive experimental campaign performed at CINECA, the Italian supercomputing center, and on the Microsoft Azure HDInsight data platform. Results have shown that the achieved accuracy is around 9.5% for Map Reduce and about 10% for Spark of the actual measurements on average.
Regulation of Reticuloendothelial Iron Transporter MTP1 (Slc11a3) by Inflammation*

Acute and chronic inflammation cause many changes in total body iron metabolism including the sequestration of iron in phagocytic cells of the reticuloendothelial system. This change in iron metabolism contributes to the development of the anemia of inflammation. MTP1, the duodenal enterocyte basolateral iron exporter, is also expressed in the cells of the reticuloendothelial system (RES) and is likely to be involved in iron recycling of these cells. In this study, we use a lipopolysaccharide model of the acute inflammation in the mouse and demonstrate that MTP1 expression in RES cells of the spleen, liver, and bone marrow is down-regulated by inflammation. The down-regulation of splenic expression of MTP1 by inflammation was also observed in a Leishmania donovani model of chronic infection. The response of MTP1 to lipopolysaccharide (LPS) requires signaling through the LPS receptor, Toll-like receptor 4 (TLR4). In mice lacking TLR4, MTP1 expression is not altered in response to LPS. In addition, mice lacking tumor necrosis factor-receptor 1a respond appropriately to LPS with down-regulation of MTP1, despite hyporesponsiveness to tumor necrosis factor-α signaling, suggesting that this cytokine may not be required for the LPS effect. We hypothesize that the iron sequestration in the RES system that accompanies inflammation is because of down-regulation of MTP1.