Miracle-dz/UniFAR-FTUs huggingface dataset:
Maternal pBMI and the programming of hypertension

Adverse intrauterine conditions can program hypertension. Because one of the underlying mechanisms is thought to be cardiac autonomic balance, we investigated the association between prepregnancy body mass index (BMI) and blood pressure and indicators of the autonomic balance in the child at age 5 to 6 years. Also investigated was whether these associations were mediated by standardized birth weight and child BMI. Pregnant women (n=3074) participating in the Amsterdam Born Children and their Development study completed a questionnaire at gestational week 14. At age 5 to 6 years, offspring’s sympathetic drive (pre-ejection period), parasympathetic drive (respiratory sinus arrhythmia), and heart rate were measured by electrocardiography and impedance cardiography at rest. Blood pressure was assessed simultaneously. After adjusting for possible maternal/offspring confounders, prepregnancy BMI was positively linearly associated with diastolic blood pressure (β=0.11 mm Hg; 95% confidence interval, 0.05–0.17), systolic blood pressure (β=0.14 mm Hg; 95% confidence interval, 0.07–0.21), but not with heart rate, sympathetic or parasympathetic drive. After adding birth weight and child BMI to the model, the independent effect size of prepregnancy body mass index on systolic blood pressure (β=0.07 mm Hg; 95% confidence interval, 0.00–0.14) and diastolic blood pressure (β=0.07 mm Hg; 95% confidence interval, 0.01–0.13) decreased by ≈50%. Birth weight did not mediate these relationships, but was independently and negatively associated with blood pressure. Child BMI was positively associated with blood pressure and partly mediated the association between prepregnancy BMI and blood pressure. In conclusion, higher prepregnancy BMI is associated with higher blood pressure in the child (aged 5–6 years) but does not seem to be attributable to early alterations in resting cardiac autonomic balance. Child BMI, but not birth weight, mediated the association between prepregnancy BMI and blood pressure. (Hypertension. 2013;62:641-647.) • Online Data Supplement
Synthesis and analysis of LiNb 03 ceramic powders by co-precipitation method

This paper brings out the results concerning structural, magnetic q f :~# r i ca l properties nano sized GdFe03 ceramic powder samples that are synthesized by a;"Sjqrecipitation method. Five samples have thus been obtained sintering dbv at tha bm$btures of 5 0 0 ' ~ , 600'~, 700 C, SOO'C, and ~OO'C, respectively The XRD h f i l e s of GdPa03 nano particles have been investigated to understand the chdgfts in t heh rystaf sfhctures in varied temperatures to identify an optimized the iemmture~4them. $~orpho10gy of' the GdFe03 nano particles have been exam froq the ~ u r ~ $ h t of HRSEM images. Elements present in sample GdFeO#! $'bee~-analyza based on its EDAX profile measurement. For these samples, their dlolectrjc, $tpedance spectroscopy properties have been studied at room telapmture from 1Hz -1Mhz. Magnetic hysteresis loops of the samples have also been exarfiipbd 4 d i f f e h t temperatures to determine the in different magnetodielectric devise applications.
Institutionalisation, Deinstitutionalisation and Change: The Context of Policy Change for Software Exports in Costa Rica

This paper addresses deinstitutionalisation from a longitudinal perspective. Drawing on the case of software exports policymaking in Costa Rica, it analyses persistence and change paying particular attention to formation of dissensus, understood as lack of unanimity on the value of an activity that is sufficient to destabilise institutional norms and activities. The role of cultural and political factors in deinstitutionalisation or persistence is considered. Based on the empirical data, a framework for understanding political and cultural dynamics in deinstitutionalisation is proposed. How to quote or cite this document Nicholson, Brian, & Sahay, Sundeep. (2008). Institutionalisation, Deinstitutionalisation and Change: The Context of Policy Change for Software Exports in Costa Rica. Manchester Business School Working Paper, Number 538, available: http://www.mbs. ac.uk/research/working-papers.aspx.
Gutbrodt Activity Against Acute Myeloid Leukemia Antibody-Based Delivery of Interleukin-2 to Neovasculature Has Potent

confirm efficacy. cells. Early results from clinical trials support these results in human patients, although further trials are needed to T + Indeed, this effect was long-lasting in immunocompetent mice and was mediated by both natural killer and CD8 inhibit AML progression. The effect was further enhanced by combination with the chemotherapeutic cytarabine. took this observation into mouse models and found that if they fused interleukin-2 to the targeting antibody, they could these vessels could be stained by clinical-stage human antibodies against tumor angiogenesis markers. They then The authors observed that AML patients have increased blood vessel density in the bone marrow, and that patients with acute myeloid leukemia (AML) has activity against blood-borne cancers as well. find that targeting neovascular structures found in the bone marrow of et al. tumors like leukemias. Now, Gutbrodt development. However, angiogenesis-targeting therapy has been relatively neglected in the context of blood-borne nutrients to all parts of the tumors, and targeting these new vessels has long been a focus of cancer therapy is thought to be critical to bring oxygen and −− angiogenesis −− For solid tumors, new blood vessel formation The Blood Mobile
With Coronary Artery Disease White Blood Cell Counts , Leukocyte Ratios , and Eosinophils as Inflammatory Markers in Patients

Inflammation is a key feature of atherosclerosis and its clinical manifestations. The leukocyte count has emerged as a marker of inflammation that is widely available in clinical practice. Since inflammation plays a key role in atherosclerosis and its end results, discovering new biomarkers of inflammation becomes important in order to help diagnostic accuracy and provide prognostic information about coronary cardiac disease. In acute coronary syndromes and percutaneous coronary intervention, elevated levels of almost all subtypes of white blood cell counts, including eosinophils, monocytes, neutrophils, and lymphocytes, and neutrophil–lymphocyte ratio and eosinophil–leukocyte ratio constitute independent predictors of adverse outcomes. Eosinophil count and eosinophil–leukocyte ratio, in particular, emerge as novel biomarkers for risk stratification in patients with coronary artery disease. Since the presence of eosinophils denotes hypersensitivity inflammation and hypersensitivity associated with Kounis syndrome, this reality is essential for elucidating the etiology of inflammation in order to consider predictive and preventive measures and to apply the appropriate therapeutic methods.
Physics ) TITLE : Ellipsometry as a Probe of Thin Copolymer Films : Crystallisation & Morphology

This study presents results on the use of ellipsometry as a novel probe for thin films of a diblock copolymer. Ellipsometry makes use of the change in polarisation induced upon reflection of light from a film covered substrate to enable calculation of the refractive index and thickness of the film. The infom1ation obtained in these measurements can be compared to differential scanning calorimetry, with the additional advantages that small sample volumes and slow cooling rates can be employed, and expansion coefficients can be determined. The work is presented in two parts; first crystallisation within the phase-separated domains is studied, then a morphological transition in the diblock ordering is characterised. By studying the temperature dependence of the film thickness and refractive index, crystallisation kinetics within very small volumes('"'"' 10L) of a poly (butadiene-b-ethylene oxide) diblock copolymer are measured. Through a comparison of two different PEO block lengths, a reduction in both the crystallisation and melting temperatures is demonstrated as the domain volume is decreased. Upon cooling, an additional transition is observed. We ascribe this to a morphological transition from a layer of ordered spheres to a lamellar layer at the substrate, which is consistent with a comparison between the data and simulated ellipsometry data. The sensitivity of ellipsometry makes it a well suited and versatile technique for probing thin film kinetics in diblock copolymers.
Users ’ Switching Behavior

This paper reviews the researches of online users switching behavior and emphases the importance of online users’ switching behavior. By reviewing the literature, we find that satisfaction, alternatives attractiveness and switching costs are the main factors affecting the user switching intention, and we also analyze different theoretical models. Finally, this study summarizes the facilitation factors and inhibition factors, which are able to influence online users’ switching intention. Practical implications and theoretical contributions are given.
Ramón Cava and Rosario Ramírez quality High-pressure processing of a raw milk cheese improved its food safety maintaining the sensory

The effect of high-pressure treatment (400 or 600 MPa for 7 min) on microbiology, proteolysis, texture and sensory parameters was investigated in a mature raw goat milk cheese. At day 60 of analysis, Mesophilic aerobic, Enterobacteriaceae, lactic acid bacteria and Listeria spp. were inactivated after high-pressure treatment at 400 or 600 MPa. At day 90, mesophilic aerobic, lactic acid bacteria and Micrococacceae counts were significantly lower in high-pressure-treated cheeses than in control ones. In general, nitrogen fractions were significantly modified after high-pressure treatment on day 60 at 600 MPa compared with control cheeses, but this effect was not found in cheeses after 30 days of storage (day 90). On the other hand, high-pressure treatment caused a significant increase of some texture parameters. However, sensory analysis showed that neither trained panellists nor consumers found significant differences between control and high-pressure-treated cheeses.
Detection of Heavy Metal Ions in Water by PAA/CNTs Nanosensor

A novel technique for rapid and ultrahigh sensing of heavy metals in water based on Porous Anodic Alumina (PAA) membrane functionalized with randomly distributed Carbon Nanotubes (CNTs) of 20 nm diameters is introduced. The proposed sensor demonstrated high selectivity between three different heavy metals (Hg, Cd, and Pb) with concentrations varied from 1 to 100 ppb. The platform provides an instant and fully integrated detection method that is based on in-situ surface-enhanced Raman scattering (SERS) spectroscopy. The observed Raman enhancement is due to the excitation and interference of laser waves, which are highly dependent on the type and concentration of the heavy metal. Â As a result, the proposed sensor is an unprecedented fully integrated Nano platform that is easy to fabricate.
On Anderson et al . ( 2015 ) ’ s Sinusoidal Time Variation of the Newtonian Gravitational Constant

In a recent publication, Anderson et al., [Europhys. Lett. 110, 10002, (2015)], presented a strong correlation between the measured values of the Newtonian gravitational constant G and the 5.9 year oscillation of the length of day. Following this publication of Anderson et al., (2015), S. Schlamminger et al., [Phys. Rev. D 91, 121101(R), (2015)] compiled a more complete set of published measurements of G made in the last 35 years where they performed a least-squares regression to a sinusoid with period 5.9 years and found this fit to still yields a reasonable fit to these data thus somewhat putting credence to this claim of Anderson et al. (2015). However, it is yet to be established as to whether or not this signal is gravitational in origin. In this brief communication, we point-out that – in principle – this sinusoidal signal has a place in the gravitomagnetic model that we currently working on.
Piecemeal Rupture of the Mentawai Patch, Sumatra: The 2008 Mw 7.2 North Pagai Earthquake Sequence

The 25 February 2008 Mw 7.2 North Pagai earthquake partially ruptured the middle section of the Mentawai patch of the Sunda megathrust, offshore Sumatra. The patch has been forecast to generate a great earthquake in the next few decades. However, in the current cycle the patch has so far broken in a sequence of partial ruptures, one of which was the 2008 event, illustrating the potential of the patch to generate a spectrum of earthquake sizes. We estimate the coseismic slip distribution of the 2008 event by jointly inverting coseismic offsets from GPS and interferometric synthetic aperture radar. We then estimate afterslip with 5.6 years of cumulative GPS displacements. Our results suggest that the estimated afterslip partially overlaps the coseismic rupture. The overlap of coseismic rupture and afterslip can be explained conceptually by a simple rate‐and‐state model where the degree of overlapping is controlled by the dynamic weakening and the critical nucleation size in the velocity‐weakening area. Comparing our rate‐and‐state model results with our geodetic inversion results, we suggest that the part of the coseismic rupture that does not overlap with the afterslip may represent a velocity‐weakening region, while the overlapping part may represent a velocity‐strengthening region.
Treatment Population : Early Findings From the NAVIPPRO Surveillance System Nonmedical Use of Prescription ADHD Stimulant Medications Among Adults in a Substance Abuse

Objective: To examine nonmedical use (NMU) of prescription ADHD stimulants among adults evaluated for substance abuse treatment. Method: 147,816 assessments from the National Addictions Vigilance Intervention and Prevention Program (NAVIPPRO) system (10/01/2009 through 03/31/2012) examined NMU prevalence, routes of administration (ROA), and diversion sources. Results: Past 30-day NMU for prescription stimulants (1.29%) was significantly lower than that of prescription opioids (19.79%) or sedatives (10.62%). For stimulant products, NMU for Adderall was 0.62, followed by Adderall XR (0.42), Ritalin (0.16), Vyvanse (0.12), and Concerta (0.08); product differences likely have limited clinical relevance given the low estimates (<1%). Higher NMU per prescriptions was for Adderall (4.92), Ritalin (4.68), and Adderall XR (3.18) compared with newer formulations (Vyvanse 1.26, Concerta 0.89). Diversion source was mainly family/ friends with no differences between products; swallowing whole was the most frequent ROA. Conclusion: Prescription stimulant NMU was low compared with other prescription medications among individuals assessed for substance abuse problems, with little difference among specific products. (J. of Att. Dis. 2013; XX(X) 1-XX)
Petersdorf Hematopoietic Cell Transplantation MHC-Resident Variation Affects Risks After Unrelated Donor

transplantation. decrease their risk of GVHD. Thus, non-HLA SNP screening could improve patient outcome after hematopoietic basis of the currently available donor pool, recipients may be able to further match SNPs before transplant to disproportionately. Of these, two SNPs were markers of disease-free survival and acute GVHD. Moreover, on the were not in the HLA. Outcome did not depend on the total number of SNPs; rather, specific SNPs contributed The authors scanned more than 4000 samples in HLA-matched donor-recipient pairs for MHC region SNPs that polymorphisms (SNPs) within the MHC, but not in the HLA, that may contribute to the development of GVHD. identify single-nucleotide et al. fully HLA-matched, but unrelated, donors develop GVHD. Now, Petersdorf hematopoietic cell transplantation Transplants from related donor are preferred, because up to 80% of recipients of blood cells attack the recipient. GVHD is the leading cause of early complications and death after unrelated donor a side effect of blood cell transplant where the donor −− rejection but also to limit graft-versus-host disease (GVHD) matching of human leukocyte antigens (HLAs), which are found in the MHC, is critical not only to prevent transplant The major histocompatibility complex (MHC) governs the acceptance or rejection of grafts. Donor-recipient SNPing Away at Graft-Versus-Host Disease
Combined economic and emission dispatch considering conventional and wind power generating units

Summary Combined economic and emission dispatch (CEED) is an optimization solution to the short-term demand and supply balancing in the power network. Given that wind power is playing an increasing role in the UK, this paper develops a CEED model for a combined conventional and wind power system under the UK energy policies. The proposed model aims to determine the optimal operation strategy for the given system with the consideration of wind power curtailment and reservation and also the environmental aspect, especially the carbon price of greenhouse gases (GHG) and emission limits of decarbonization scenarios. From 2 case studies, increasing the carbon price at a low emission limit leads to an increase in the total cost, but the rate of the increase is mitigated on decreasing the emission limits. Moreover, dispatch is dominated by the carbon price at high emission allowance levels and by the emission allowance at low emission allowances.
Dynamic strategic responses among advertisers: the case of meat products

The case of strategic advertising response is examined for branded and generic meat products (beef, pork, and poultry). A dynamic conceptual model is developed to identify the determinants of advertising expenditures. A time-series model is then used to examine the competitive behavior of branded and generic meat advertisers. The results identify two types of advertising strategies those based upon changes in revenues and those based upon changes in competitor advertising expenditures. Most groups employ a mix of revenue-based and advertising-based strategies. The results identify examples of both strategic substitutes and strategic complements. No long-run response to generic advertising by brand advertisers in the same commodity group is found.
Mechanics of Advanced Composite Structures

Pa per hist ory: Received: 2016-05-27 Revised: 2016-07-23 Accepted: 2016-08-26 In this study, static and free vibration analyses of functionally graded (FG) nanocomposite plates, reinforced by wavy single-walled carbon nanotubes (SWCNTs) resting on a Pasternak elastic foundation, were investigated based on a mesh-free method and modified first-order shear deformation theory (FSDT). Three linear types of FG nanocomposite plate distributions and a uniform distribution of wavy carbon nanotubes (CNTs) were considered, in addition to plate thickness. The mechanical properties were by an extended rule of mixture. In the mesh-free analysis, moving least squares (MLS) shape functions were used for approximation of the displacement field in the weak form of a motion equation, and the transformation method was used for imposition of essential boundary conditions. Effects of geometric dimensions, boundary conditions, the type of applied force, and the waviness index, aspect ratio, volume fraction, and distribution pattern of CNTs were examined for their effects on the static and frequency behaviors of FG carbon nanotube reinforced composite (CNTRC) plates. Waviness and the distribution pattern of CNTs had a significant effect on the mechanical behaviors of FG-CNTRC plates, even more than the effect of the CNT volume fraction. Keyw ord s: Static Free vibration Wavy carbon nanotube Nanocomposite plates Mesh-Free © 2016 Published by Semnan University Press. All rights reserved.
Learning Torque-Driven Manipulation Primitives with a Multilayer Neural Network

Autonomous learning of robotic motion skills promises to allow robots to acquire large motion repertoires for interacting with the real world with minimal human intervention. However, most current robotic motion skill representations are compact and lacking in expressiveness. This limitation is due in large part to the difficulty of learning rich representations in the context of optimal control and reinforcement learning. We discuss our recent experiments on using the guided policy search method to learn multilayer neural network policies for robotic manipulation skills. The key idea in this approach is to turn the task of policy search into a supervised learning problem, so that known, reliable optimization algorithms can be used to train expressive function approximators with thousands of parameters. While our networks are small compared to those used for perception (two hidden layers with 40 units each), they are significantly more expressive than most controller representations in reinforcement learning. We present results for neural network control of a PR2 robot, and discuss future work on learning policies that directly map rich sensory input to joint torques using deep neural networks.
Tilemann Model of Heart Failure Gene Transfer Improves Cardiac Function in a Large-Animal SUMO-1

the short-term. gene therapy from pigs to humans seems likely in SUMO-1 clinical trials, moving SERCA2a the precedent set by the additional beneficial effects, but more mechanistic studies will be needed to understand this potential synergy. With suggested SERCA2a and SUMO-1 ATPase activity afforded by increased SUMO-1 protein levels. Delivery of both 2+ authors, the functional improvements in this model of heart failure are most likely the result of improved SR Ca improved cardiac contractility and prevented left ventricular dilatation (two major aspects of HF). According to the directly to the heart of these animals showed SUMO-1 pig model of HF. In addition to being safe, administering gene transfer alone and to the combined delivery of both genes in a SERCA2a gene transfer to SUMO-1 efficacy of an important regulator of SERCA2a. The authors compared the −− ) SUMO-1 ( small ubiquitin-related modifier 1 designed a large-animal study that also tests the delivery of et al. , Tilemann SERCA2a events. To boost the effects of ) in patients has made it to phase 2b/3 trials, with early signs pointing to an improvement in HF-related SERCA2a ( adenosine triphosphatase 2+ sarcoplasmic reticulum Ca targeting cardiac-specific pathways. Replacing the gene death in the Western world. Gene therapy has been proposed as a way to coerce the heart into being healthy by Heart failure (HF) is one of the top reasons for hospitalization among the elderly and remains a leading cause of Cardiac Gene Therapy to the Rescue
Jian Zheng Immunity in Humanized Mice Regulatory T Cells Inhibit GVHD and Preserve General + Human CD 8

may prevent the need for long-term general immunosuppression in BMT recipients. regs T hi humans, CD8 mechanism that involved CTLA-4, and, indeed, induced long-term tolerance. If these results can be translated to general immune responses intact. These cells decreased organ-specific chemokine and cytokine secretion through a reduced GVHD in an allospecific manner while leaving graft versus tumor and regs T hi generated CD8 − these ex vivo ) into a humanized model of GVHD. They found that regs regulatory T cells (T hi The authors transplant CD8 report a way to specifically inhibit GVHD in a humanized mouse model. et al. controlled by general immunosuppression, which has its own waterfall of negative side effects. Now, Zheng as ''nonself'' and attack. This side effect of BMT is called graft-versus-host disease (GVHD) and is −− treated the patient being −− to the recipient. Thus, immune cells that develop from the transplant recognize the new host they are antigenically foreign −− and nonmalignant diseases of the blood. Most bone marrow transplants are allogeneic unwanted side effects. One such therapy is bone marrow transplantation (BMT), which is used to treat both malignant Sometimes the treatment is worse than the disease. Therapies for critical illnesses frequently have severe Transplanting Hope