Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Mangosteen Pericap (Garcinia Manggostana Linn) as Lipid Lowering Agent in Mice Model Dyslipidemia

Background. Dyslipidemia is a risk factor of atherosclerosis, characterized by increase total cholesterol (TC), trigliserida (TG), Low Density Lipoprotein (LDL) and decrease of High Density Lipoprotein(HDL). Previous study showed positive correlation between dyslipidemia with severity of atherosclerosis. Effect of pericap mangosteen contains Xanthone presumed could decreased the total cholesterol (TC), triglyceride (TG), and Low Density Lipoprotein(LDL) levels and increased High Density Lipoprotein(HDL) level from the blood of white mice by activated the path of reverse cholesterol transport. Purpose. To prove that extract from pericap mangosteen decrease LDL, triglyceride, total cholesterol and increase HDL. Methode. Laboratory experiment with the post test only control group design. The samples strain wistar white rats were devided into 5 groups. The sample I : Negative control, II : Positive control and the three other groups were treated by extract from pericap mangosteen with variouse doses (200mg/day, 400mg/day, 800 mg/day). The data were analyzed by One Way Anova, Tukey test 5%, correlation test and linear regression test. Result. The result of this observation showed that efective dose of extract of pericap mangosteento decrease TC, TG and LDL level and increase HDL level is 800 mg/day. TC lowering in group were treated with extract from pericap mangosteen 200mg/dayis= 39,667 400mg/day = 27,833 800mg/ day = 19,333. TG lowering in group were treated with extract from pericap mangosteen 200mg/dayis = 40,333 400mg/day = 34,333 800mg/day = 26,667. LDL lowering in group were treated with extract from pericap mangosteen 200mg/dayis = 45,433400mg/day = 32,467 800mg/day = 14,733. HDL raising in group were treated with extract from pericap mangosteen 200mg/day is = 13,833400mg/day = 11,500 800mg/day = 3,000 Coclusion. Oral administration (200, 400 dan 800 mg/day) of extract from pericap of mangosteen decreasing LDL, trygliseride, total cholesterol and increasing HDL of dyslipidemia male white rate. (J Kardiol
Synthesis, Characterization, Antibacterial and Antifungal Evaluation of Novel Cyclohexanone Benzoylhydrazones

DOI : 10.26650/IstanbulJPharm.2019. 19022 A novel series of benzoyl hydrazones (2a-j) have been synthesized and evaluated, in vitro, for antimicrobial activity against selected bacteria and fungi. The structures of the compounds were established by IR, 1H-NMR, 13C-NMR (APT), electrospray ionization mass spectrometry (ESI-MS) and microanalysis (C, H, N). All of the tested compounds, except for compound 2h, displayed weak antibacterial properties against Staphylococcus epidermidis ATCC 12228 and Staphylococcus aureus ATCC 29213. Compounds 2a, 2b, 2e, 2f and 2i further exhibited marginal antifungal activity against Candida parapsilosis. You may cite this article as : Cihan-Ustundag G, Mataraci-Kara E, Capan G (2019). Synthesis, Characterization, Antibacterial and Antifungal Evaluation of Novel Cyclohexanone Benzoylhydrazones. Istanbul J Pharm 10.26650/IstanbulJPharm.2019. 19022.
Suitability of foliar N applied to rainfed maize in permanent beds after 12 crop seasons of granular N application

Abstract Yield and kernel quality of rainfed maize as affected by N fertilizer has been generally evaluated through the application of granular N sources at high rates. The purpose of this work was to estimate the response of maize yield and quality (kernel hardness—floating index, weight and test weight -, P uptake and protein) to foliar N application and preceding granular N. Data for this report were collected in 2014 and 2015 in a long-term experiment established in 2002 under permanent beds in a split plot arrangement. Main plot treatments were three foliar N rates (0, 4.5 and 9 kg ha−1) laid out on the top of four preceding granular N rates (0, 20, 40 and 60 kg ha−1) applied from 2002 to 2013 as subplots. Weather conditions were relatively wetter in 2014 than 2015. In 2014, test weight and floating index improved over that in 2015. Foliar application of 9 kg N ha−1 enhanced yield and protein. In 2014, yield response to preceding N rates showed an increasing trend whereas in 2015 response was null. Kernel P uptake response to preceding N rates showed a differential reaction among foliar N rates; 9 kg ha−1 showed the greatest uptake. Kernel floating index was associated to kernel P uptake. Apparently, this relationship has not been previously reported. Results suggests that the application of 9 kg N ha−1 to foliage of rainfed maize grown in permanent beds has the potential to substitute the traditional fertilization practice of granular N sources.
Total joint arthroplasty patients' adherence to a pre-operative staphylococcus aureus decolonization protocol

ii Preface. iv List of Tables . vii List of Figures . viii Acknowledgements. ix Chapter 1: Introduction . 1 Background . 1 Significance of the problem. 1 Problem statement and purpose . 4 Research Questions. 5 Theoretical Framework. 5 Chapter 2: Literature Review. 8 Search Strategy . 10 Search Results. 14 Methods of the Selected Studies . 14 Study design. 14 Study target populations and settings . 15 Variables examined. 17 Statistical analyses . 20 Instruments Used for the Measurement of Relevant Concepts. 21 Self-efficacy. 21 Measuring adherence . 25 Research Findings. 28 Age and adherence. 28 Self-efficacy and adherence. 34 Limitations of the Research . 39 Chapter 3: Methods. 42 Study Design. 42 Sampling Plan . 42
Inzidenz und Komplikationen osteoporotischer Frakturen in Jena/Thüringen

Zusammenfassung Ziel Im Rahmen einer prospektiven Untersuchung wurde die Inzidenz osteoporosetypischer Frakturen und ihrer Komplikationen über den Zeitraum von einem Jahr in der Bevölkerung der Stadt Jena erfasst. Ergebnisse 698 Patienten erlitten Frakturen. Frauen waren bei Fraktureintritt älter als Männer. Die Inzidenz von proximalen Femurfrakturen stieg nach dem 75. Lebensjahr exponentiell an und wies eine hohe Komplikationsrate auf. Die Häufigkeit von Komplikationen nach einer Fraktur war bei Frauen über 70 Jahre mindestens doppelt so hoch wie bei Männern. In beiden Geschlechtern zeigten sich nach einer operativen Therapie mehr Komplikationen als nach konservativer Frakturversorgung. Transfusionsbedürftige Anämie, Harnwegsinfekte und Pneumonien waren die wesentlichen internistischen Komplikationen. Die Mortalität nach proximalen Femurfrakturen lag bei 9,8 %.
Heat stress and dietary vitamin supplementation of poultry diets

A seasonal problem in many parts of the world, a high ambient temperature causes economic losses through reducing feed intake while decreasing nutrient utilization, live weight gain, egg production, egg quality and feed efficiency of poultry. Several methods are currently available to alleviate the negative effects of high environmental temperature on the performance of poultry. However, since it is expensive to cool buildings in which animals are housed, such methods are focused mostly on dietary manipulation. In terms of reducing the negative effects of environmental stress, vitamin C, vitamin E and vitamin A are used in the poultry diet because of the reported benefits of these vitamins including their anti-stress effects and also due to the fact that their utilization and thus normal concentrations are reduced during heat stress. This review focuses on the effects of dietary vitamin (C, E and A) supplementation in poultry reared under chronic heat stress.
Epidemiology Of Human Pulmonary Infection With Nontuberculous Mycobacteria In Southeast China: A Prospective Surveillance Study

Background China is facing a great challenge of pulmonary nontuberculous mycobacteria (NTM) infections. This primary objective of this study was to assess the prevalence of NTM isolates among patients with presumptive TB in Fujian. Methods The mycobacterial isolates were collected from the tuberculosis survey from Fujian Province conducted between July 1, 2010 and June 30, 2011. Results From July 1, 2010 to June 30, 2011, 1425 isolates were included in the final analysis, of which 60 (4.2%) were identified as NTM species. M. intracellulare was the most frequently isolated NTM in Fujian, accounting for 68.3% of all NTM isolates. Compared with patients aged <45 years, patients aged 45–59 were more likely to have NTM infections. The education level of patients had an impact on the distribution of NTM infections. Illiterate patients had significantly higher odds of having NTM compared to literate patients. Patients with a previous TB episode had higher NTM risk as compared to those without previous TB episodes. Conclusion In conclusion, the predominant NTM is M. intracellulare among patients with presumptive TB in Fujian. In addition, elderly patients, those with a previous TB episode and illiterate patients have higher NTM risk.
Effect of a paediatric incentive spacer and reinforcement of inhalation technique training in preschool children

Incorrect inhaled drug delivery technique is a common problem in paediatric asthma [1-4]. Previously, device technique training has been shown to significantly improve inhaler skills, using subjective methods, namely check-list analysis [5-8]. However, more objective measures are needed to examine more comprehensively the effect of training in preschool children and parents. Resistance to regular asthma therapy is also a frequent problem when attempting to treat young children. Reasoning with young children can be very difficult and parents often have to struggle with their child to achieve compliance [2]. The Funhaler spacer (FH) (FunhalerTM; InfaMed, Australia) has been developed in an attempt to resolve this issue by incorporating incentive toys to distract the child from the drug delivery process. Based on parental questiom1aire, the FH has been shown to improve inhalation technique and increase medication compliance in young children over a two-week period [1]. A total of 4 7 children participated in the present study; 24 were randomised to a standard Aerochamber plus spacer (AC+) (15 male, mean age 63.7 months, range 3090 months), and 23 were randomised to the FH spacer (14 male, mean age 60.5 months, range 36-90 months). Of the 47, four children (AC+: n=2, FH: n=2), with a mean age of 51 months (36-60 months) were identified as nose breathers, and were analysed as a separate group. The results from the present study show that repeated clinic-based technique training had no significant effect on drug delivery (p=O.l51 ). Furthermore, it was fo~rid that in the clinic setting, children who were using the FH
William Barlow’s early publications in the ‘Zeitschrift für Krystallographie und Mineralogie’ and their influence on crystal structure research

Abstract The English crystallographer William Barlow is famous for two achievements, both published in German, in Zeitschrift für Krystallographie und Mineralogie between 1894 and 1901. They concern the derivation of all possible symmetrical arrangements of points in space and the idea to represent crystal structures by replacing points by spheres. His results had an impact upon crystal structure modelling and describing crystal morphology. Utilizing self-made models, he found the 230 space group types of symmetry obtained earlier by both E. S. Fedorow and A. Schoenflies in a different manner. The structures he proposed before the discovery of X-ray diffraction served in some cases as starting point for the interpretation of diffraction patterns thereafter.
A novel characterization of patient arrival process in healthcare facilities

Appropriate modelling for patient arrival is the first step in investigation of factors contributing to waiting time of both patients and the doctor in clinics. In previous practice, scheduled patient’s unpunctuality (i.e., the deviation from the scheduled appointment time) is often modelled either too typical that excludes some fundamental features of clinical observations, or too complex that might bring excessive difficulty to simulate and analyze. From observations of detailed workflow of community clinics, we can find that these models are not generally valid. In this paper, we proposed a modelling technique to characterise patient unpunctuality considering various groups of patient arrival behaviour. The adequacy of this model can be assessed by variation and standard error comparison with normal and Pearson type distributions. A sample simulation is given to exam the effects of various modelling techniques on patient waiting time and the doctor idle time. This proposed modelling technique might provide fundamental basis for improvement of appointment scheme in practical applications.
The scientific term paper at the Charité: a project report on concept, implementation, and students' evaluation and learning

Aim: Better training in scientific skills, such as the ability to conduct research independently, has been one of the main drivers of reform in medical education. The aim of this article is to report on the scientific term paper module in the modular curriculum of medicine (MCM) at the Charité. This module is an established example of undergraduate medical students conducting their own scientific investigations. Project outline: A faculty-wide, outcome-oriented process resulted in a four-week module for writing a scientific term paper in the 6th semester of the MCM as part of a longitudinal science curriculum. Acquired competencies were assessed through a written term paper and an oral presentation. Two student cohorts (winter terms 2013 and 2014) were surveyed on how they rated the module concept, organizational aspects and the quality of support. We further analysed the chosen topics of the papers as well as student assessment results. Results: The student evaluation (return rates of 193 and 197, 71% and 77%) showed high overall satisfaction with the module. This result was evident in the high rating of the module concept and organizational aspects, a positive attitude towards scientific research, and strong motivation to pursue further scientific research. There was a wide spectrum of term paper topics with a focus on literature reviews. Most of the student work was assessed as good or very good. Conclusion: The scientific term paper module has proven itself as a curricular concept for students to perform own scientific research in the MCM, with strong acceptance and good performance by students. This project report can serve as basis and guidance for development and further improvements to promote scientific competencies in undergraduate medical education in other faculties.
Preparation of Carbon Dots with High-Fluorescence Quantum Yield and Their Application in Dopamine Fluorescence Probe and Cellular Imaging

Carbon dots represent a kind of fluorescent nanomaterial and have broad application prospects in the field of biosensing and optoelectronics. Here, we explored carbon dots with a high-fluorescence quantum yield rate synthesized from L-cysteine and citric acid by the microwave-assisted method. The characteristics of the carbon dots were studied using a transmission electron microscope, an X-ray diffractometer, X-ray photoelectron spectra, a UV-Vis absorption spectrometer, a FTIR spectrometer, and a fluorescence spectrophotometer. The obtained carbon dots exhibited a high-fluorescence quantum yield (up to 85%), which is due to the combination of amidogens and sulfydryl with carbon dots, and hence bring the improved fluorescence property. We used carbon dots for in vitro imaging of CRL-5822 cells and human umbilical vein endothelial cells, which showed the low inhibitory rate (0.8%) of cells for 48 h with good biocompatibility demonstrated by the cell viability assay. The image of cells can be observed clearly under UV light. The Stern-Volmer equation was introduced to describe the quenching effect between the fluorescence intensity of carbon dots and the concentration of aqueous dopamine (DA).
Mental Health Service Needs in the Prison Boom: The Case of Children of Incarcerated Mothers

This study identifies the factors related to mental health service use among children of incarcerated mothers. Data on 700 children collected from a diverse sample of mothers in Arizona are used, and a two-stage probit model with sample selection is estimated to assess the various child, mother, and caregiver characteristics associated with children’s use of mental health services. Results indicate that children involved in child protective services (CPS) and children cared for by grandparents are more likely to receive mental health services, whereas children of Native American mothers and children who have been exposed to violence are less likely to receive services for their mental health needs. These findings have important implications for correctional policy regarding the intake screening of female inmates and suggest that criminal justice agencies communicate more closely with CPS and community-based services to ensure children’s mental health needs are addressed while their mothers are in prison.
Process Optimization-Based Screening of Zeolites for Post-Combustion CO2 Capture by Vacuum Swing Adsorption

A total of 119 661 hypothetical zeolites, 1031 zeolite immidazolate frameworks, and 156 zeolites identified by the International Zeolite Association are screened for their effectiveness as adsorbents for postcombustion CO2 capture from a dry flue gas using vacuum swing adsorption. A batch adsorber analogue model is used to identify materials that meet the target CO2 purity of 95% and recovery of 90%. The screening indicates a minimum Henry’s selectivity of 13 is required to meet these targets. The lowest energy consumption adsorbents showed CO2 and N2 heats of adsorption in the ranges of −32 to −42 kJ/mol and −8 to −17 kJ/mol, respectively. Low N2 affinity, more than high CO2 affinity, is the characteristic of low energy consuming adsorbents. A total of 15 top performers from the screening and 24 synthesizable zeolites were optimized for low parasitic energy using a detailed process optimization. The best adsorbent showed a 16% lower energy consumption compared to the current benchmark, Zeolite 13X.
Effect of biopolymer coating on texture characteristics of dry fermented sausage during storage

In this paper, the changes of texture characteristics of Petrovská klobása, a traditional dry-cured sausage, were analysed during 150 days of storage. Sausages were produced in the traditional manner, but underwent drying and ripening processes in industrial conditions. Chitosan was used to coat experimental sausages after the drying process was considered finished. Changes in moisture content were measured during the storage period, but the differences between control and chitosan coated sausages were not significant (P>0.05). Changes in moisture content influenced progressive increases in hardness and chewiness of both groups of sausages. The differences in texture characteristics between the different sausage groups were not significant for the entire storage period. Chitosan coating had no positive influence on preventing texture changes in Petrovská klobása during storage.
Phthalazines and phthalazine hybrids as antimicrobial agents: Synthesis and biological evaluation

Phthalazine and phthalazinone derivatives are important owing to their significant biological activities and pharmacological properties. Herein, a benzoic acid derivative (2), a benzoxazin-1-one derivative (3), and an oxophthalazin-2(1H)-yl)acetohydrazide (13) are utilized as precursors to construct a novel series of phthalazinones bearing various valuable functional groups in excellent yields via several simple and promising approaches. Finally, the antimicrobial activity of the newly synthesized phthalazines is screened against different microbial strains; namely, Gram-negative and Gram-positive bacteria utilizing Amoxicillin as a standard drug.
The Chelation of Metal Ions by Vicibactin, a Siderophore Produced by Rhizobium leguminosarum ATCC 14479

Vicibactin is a small, high-affinity iron chelator produced by Rhizobium leguminosarum ATCC 14479. Previous work has shown that vicibactin is produced and secreted from the cell to sequester ferric iron from the environment during iron-deplete conditions. This ferric iron is then transported into the cell to be converted into ferrous iron. This study uses UV-Vis spectroscopy as well as ion trap-time of flight mass spectroscopy to determine that vicibactin does form a complex with copper(II) ions, however, at a much lower affinity than for iron(III). Stability tests have shown that the copper(II)-vicibactin complex is stable over time. The results of this study show that vicibactin could be used in order to remove copper(II) ions from the soil or other media if they are present in toxic amounts. It also suggests that vicibactin’s purpose for the rhizobia could be expanded to include both copper sequestering and to reduce extracellular copper concentrations to prevent toxicity. UV-Vis spectroscopy in a modified Atkins’ Assay as well as mass analysis using an ion trap-time of flight mass spectrometer with both positive and negative electrospray interactions. A shift of the peak absorbance of the modified Atkins’ Assay when vicibactin was added indicated that a possible interaction between vicibactin and copper was occurring. A dose-response test was performed to confirm the significance of this interaction. Finally, mass spectroscopy was performed to determine if the interaction occurring was vicibactin chelating the copper ion. The control test showed multiple degradation products of vicibactin, some of which to retain their ability to chelate iron. However, the intact vicibactin molecule not observed. When the vicibactin was added to a modified Atkins’ Assay containing 1M perchlorate these degradation products disappeared. The peaks observed were slightly lower in mass than the expected of the copper-vicibactin complex. It that the hostile conditions vicibactin was exposed to in the mass spectrometer the loss of hydrogen ions during analysis, which accounts for the slight shift in observed. This work shows that vicibactin may be by not sequester iron, but also to possibly sequester for cellular the toxicity of concentrations of extracellular copper ions. This study also shows that vicibactin could possibly be a potential tool in environmental copper ion clean-up. The nature of the molecular rearrangement which occurs during mass spectroscopy should be explored, possibly through nuclear magnetic resonance
Quantum-mechanical survey of the novel conformational and tautomeric transformations of the classical Watson-Crick А·Т(WC), reverse Watson-Crick А·Т(rWC), Hoogsteen А·Т(Н) and reverse Hoogsteen А·Т(rН) DNA base pairs

This study represents novel and previously unknown conformational and tautomeric transformations of the classical Watson-Crick А·Т DNA base pairs – Watson-Crick А·Т(WC), reverse Watson-Crick А·Т(rWC), Hoogsteen А·Т(Н) and reverse Hoogsteen А·Т(rН), leading to the novel, nonplanar conformations or tautomers of these base pairs. Кеуwords – А·Т DNA base pairs, Watson-Crick, Reverse Watson-Crick, Hoogsteen, Reverse Hoogsteen, Wobble structure, DNA breathing, DNA pre-melting, Conformational transformation, Tautomeric transition, Transition state, Quantum-chemical calculations, Bader’s Quantum Theory of Atoms in Molecules.
Potere antiossidante di vini pugliesi

I composti polifenolici presenti nell'uva e nel vino sono stati ampiamente caratterizzati ed è noto che possiedono un alto potenziale antiossidante. Pochi studi sono stati, invece, eseguiti sul potere antiossidante dei vini pugliesi. In questo studio abbiamo esaminato il poter antiossidante di ventisette vini pugliesi, prodotti nel rispetto dei locali disciplinari per la denominazione di origine, DOP e IGP, rappresentativi di uno dei territori più importanti dell'enologia nazionale italiana. I vini ottenuti dalle uve del territorio pugliese, in particolare quelli rossi, sono ottime fonti di sostanze antiossidanti. La ricerca conferma l'elevata correlazione tra il contenuto in PFT e l'attività antiossidante misurata con il metodo ORAC (r = 0.963). Minore correlazione è stata evidenziata tra i PFT e il metodo DPPH (r = 0.538).