Miracle-dz/UniFAR-FTUs huggingface dataset:
Silencing of COPB2 inhibits the proliferation of gastric cancer cells and induces apoptosis via suppression of the RTK signaling pathway

Emerging studies have reported that coatomer protein complex subunit β2 (COPB2) is overexpressed in several types of malignant tumor; however, to the best of our knowledge, no studies regarding COPB2 in gastric cancer have been published thus far. Therefore, the present study aimed to determine the significance and function of COPB2 in gastric cancer. COPB2 expression in gastric cancer cell lines was measured using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis. In addition, lentivirus-short hairpin RNA (shRNA) COPB2 (Lv-shCOPB2) was generated and used to infect BGC-823 cells to analyze the effects of COPB2 on the cancerous phenotype. The effects of shRNA-mediated COPB2 knockdown on cell proliferation were detected using MTT, 5-bromo-2-deoxyuridine and colony formation assays. In addition, the effects of COPB2 knockdown on apoptosis were analyzed by flow cytometry. Nude mice and fluorescence imaging were used to characterize the regulation of tumor growth in vivo, and qPCR and immunohistochemistry were subsequently conducted to analyze COPB2 expression in xenograft tumor tissues. Furthermore, a receptor tyrosine kinase (RTK) signaling pathway antibody array was used to explore the relevant molecular mechanisms underlying the effects of COPB2 knockdown. The results revealed that COPB2 mRNA was abundantly overexpressed in gastric cancer cell lines, whereas knockdown of COPB2 significantly inhibited cell growth and colony formation ability, and led to increased cell apoptosis in vitro. The tumorigenicity assay revealed that knockdown of COPB2 reduced tumor growth in nude mice, and fluorescence imaging indicated that the total radiant efficiency of mice in the Lv-shCOPB2-infected group was markedly reduced compared with the mice in the Lv-shRNA control-infected group in vivo. The antibody array assay revealed that the levels of phosphorylation in 23 target RTKs were significantly reduced: In conclusion, COPB2 was highly expressed in gastric cancer cell lines, and knockdown suppressed colony formation and promoted cell apoptosis via inhibiting the RTK signaling and its downstream signaling cascade molecules. Therefore, COPB2 may present a valuable target for gene silencing strategy in gastric cancer.
A Comparison of Blood Viscosity and Hematocrit Levels between Yoga Practitioners and Sedentary Adults

Elevations in whole blood viscosity (WBV) and hematocrit (Hct), have been linked with increased risk of cardiovascular disease (CVD). Endurance training has been demonstrated to lower WBV and Hct; however, evidence supporting the efficacy of yoga on these measures is sparse. A cross-sectional study was conducted examining WBV and Hct levels between yoga practitioners with a minimum of 3 years of consistent practice and sedentary, healthy adults. Blood samples were collected from a total of 42 participants: 23 sedentary adults and 19 regular yoga practitioners. Brachial arterial blood pressure (BP) was measured and the averages of 3 measures were reported. The yoga practitioner group had significantly lower WBV at 45 s−1 (p < 0.01), 90 s−1 (p < 0.01), 220 s−1 (p < 0.05), and 450 s−1 (p < 0.05) than sedentary participants. No significant group differences in Hct (p =0.38) were found. A tendency toward lower systolic BP (p=0.06) was observed in the yoga practitioner group; however, no significant group differences in BP were exhibited. A consistent yoga practice was associated with lower WBV, a health indicator related to CVD risk. These findings support a regular yoga practice as a valid form of exercise for improving rheological indicators of cardiovascular health.
The ICES Working Group on Oceanic Hydrography: A Bridge From In-situ Sampling to the Remote Autonomous Observation Era

The ICES (International Council for the Exploration of the Sea) Working Group on Oceanic Hydrography (WGOH) was established in the late 1970’s with the aim of gathering experts in physical oceanography to provide regular science-based assessments of the North Atlantic hydrographical condition (basically termohaline fields). From the beginning, the WGOH has relied on repeated long-term in-situ sampling at key sites around the North Atlantic, the Nordic Seas and adjacent shelf seas. An annual Report on Ocean Climate (IROC), produced by the WGOH since the late 1990’s, summarizes trends in regional hydrography and identifies patterns linking these changes across the North Atlantic. Regional analyses are prepared by local experts who are directly involved in the monitoring programs responsible for collecting data presented in the report. An interactive webpage created in 2013 allows users to browse and download data that inform the IROC. Within the last two decades the physical oceanography community has evolved quickly incor- porating technological advances such as autonomous devices into classical in-situ sampling programs. The WGOH has embraced such technological developments without diverting focus from ongoing in-situ long-term monitoring programs. Having longstanding experience synthe- sizing data and expertise from a large number of operational programs spanning an extensive international footprint, the WGOH has a unique perspective to offer the global ocean observing community. Here we discuss how we might foster connections with ICES to benefit the GOOS (Global Ocean Observing System) community.
Romanian ophthalmologists in the renowned ophthalmic journals worldwide

The authors are discussing over 80 articles that they have published in the last 5 years in the renowned ophthalmic journals worldwide, which have approached, for the first time in the ophthalmic literature, the following 4 topics: the acute central/ hemicentral retinal vein occlusion, the therapeutic interventions in the fellow eye of patients with unilateral malignant glaucoma, the persistent diabetic macular edema, and the current researches in patients with neovascular age-related macular degeneration.
Dispersal of Amur tiger from spatial distribution and genetics within the eastern Changbai mountain of China

Abstract Population dispersal and migration often indicate an expanded habitat and reduced inbreeding probability, and to some extend reflects improvement in the condition of the population. The Amur tiger population in the northern region of the Changbai mountain in China mostly distributes along the Sino–Russian border, next to the population in southwest Primorye in Russia. The successful dispersal westward and transboundary movement are crucial for the persistence of the Amur tiger in this area. This study explored the spatial dispersal of the population, transboundary migration, and the genetic condition of the Amur tiger population within the northern Changbai mountain in China, using occurrence data and fecal samples. Our results from 2003 to 2016 showed that the Amur tiger population in this area was spreading westward at a speed of 12.83 ± 4.41 km every three years. Genetic diversity of the Amur tiger populations in southwest Primorye was slightly different than the population in our study area, and the potential individual migration rate between these two populations was shown to be about 13.04%. Furthermore, the relationships between genetic distances and spatial distances indicated the existence of serious limitations to the dispersal of the Amur tiger in China. This study provided important information about spatial dispersal, transboundary migration, and the genetic diversity of Amur tigers in China, showed the urgent need for Amur tiger habitat restoration, and suggested some important conservation measures, such as corridor construction to eliminate dispersal barriers and joint international conservation to promote trans‐boundary movement.
Changes in Cervical Human Papillomavirus (HPV) Prevalence at a Youth Clinic in Stockholm, Sweden, a Decade After the Introduction of the HPV Vaccine

Aim: This study aimed to follow the impact of human papillomavirus (HPV) catch-up and vaccination on the very high cervical HPV-prevalence in women at a youth clinic in central Stockholm during the period 2008–2018. Background: 2008–2010, cervical HPV-prevalence (69.5%) and HPV16 prevalence (34.7%) were high in non-vaccinated women at a youth clinic in Stockholm. 2013–2015, after the introduction of the quadrivalent-Gardasil® HPV-vaccine, HPV16 and HPV6 prevalence had decreased. Here, cervical HPV-prevalence was investigated 10 years after primary sampling. Material and Methods: 2017–2018, 178 cervical swabs, from women aged 15–23 years old, were tested for 27 HPV types by a bead-based multiplex method. HPV-prevalence data were then related to vaccination status and age and compared to HPV-prevalence in 615 samples from 2008 to 2010 and 338 samples from 2013 to 2015 from the same clinic, and to HPV types in 143 cervical cancer cases during 2003–2008 in Stockholm. Results: The proportion of vaccinated women increased from 10.7% (2008–2010) to 82.1% (2017–2018). The prevalence of all 27 HPVs, all high-risk HPVs (HR-HPVs) and the combined presence of the quadrivalent-Gardasil® types HPV16, 18, 6, and 11, was lower in vaccinated compared to unvaccinated women (67.4 vs. 93.3%, p = 0.0031, 60.1 vs. 86.7%, p = 0.0057 and 5.8 vs. 26.7%, p = 0.002, respectively). Furthermore, HPV16 prevalence in non-vaccinated women 2017–2018 was lower than that in 2008–2010 (16.7 and 34.7%, respectively, p = 0.0471) and similar trends were observed for HPV18 and 11. In both vaccinated and non-vaccinated women, the most common non-quadrivalent-Gardasil® vaccine HR-HPV types were HPV39, 51, 52, 56, and 59. Together they accounted for around 9.8% of cervical cancer cases in Stockholm during 2003–2008, and their prevalence tended to have increased during 2017–2018 compared to 2008–2010. Conclusion: Quadrivalent-Gardasil® vaccination has decreased HPV-vaccine type prevalence significantly. However, non-vaccine HR-HPV types remain high in potentially high-risk women at a youth clinic in Stockholm.
Dynamic Facial Expression of Emotion and Observer Inference

Research on facial emotion expression has mostly focused on emotion recognition, assuming that a small number of discrete emotions is elicited and expressed via prototypical facial muscle configurations as captured in still photographs. These are expected to be recognized by observers, presumably via template matching. In contrast, appraisal theories of emotion propose a more dynamic approach, suggesting that specific elements of facial expressions are directly produced by the result of certain appraisals and predicting the facial patterns to be expected for certain appraisal configurations. This approach has recently been extended to emotion perception, claiming that observers first infer individual appraisals and only then make categorical emotion judgments based on the estimated appraisal patterns, using inference rules. Here, we report two related studies to empirically investigate the facial action unit configurations that are used by actors to convey specific emotions in short affect bursts and to examine to what extent observers can infer a person's emotions from the predicted facial expression configurations. The results show that (1) professional actors use many of the predicted facial action unit patterns to enact systematically specified appraisal outcomes in a realistic scenario setting, and (2) naïve observers infer the respective emotions based on highly similar facial movement configurations with a degree of accuracy comparable to earlier research findings. Based on estimates of underlying appraisal criteria for the different emotions we conclude that the patterns of facial action units identified in this research correspond largely to prior predictions and encourage further research on appraisal-driven expression and inference.
Controllable synthesis of pomelo peel-based aerogel and its application in adsorption of oil/organic pollutants

Oil/water separation is a field of high significance as it might efficiently resolve the contamination of industrial oily wastewater and other oil/water pollution. In this paper, an environmentally-friendly hydrophobic aerogel with high porosity and low density was successfully synthesized with renewable pomelo peels (PPs) as precursors. Typically, a series of sponge aerogels (HPSA-0, HPSA-1 and HPSA-2) were facilely prepared via high-speed dispersion, freeze-drying and silanization with methyltrimethoxysilane. Indeed, the physical properties of aerogel such as density and pore diameter could be tailored by different additives (filter paper fibre and polyvinyl alcohol). Hence, their physico-chemical properties including internal morphology and chemical structure were characterized in detail by Fourier transform infrared, Brunauer–Emmett–Teller, X-ray diffraction, scanning electron microscope, Thermal gravimetric analyzer (TG) etc. Moreover, the adsorption capacity was further determined and the results revealed that the PP-based aerogels presented excellent adsorption performance for a wide range of oil products and/or organic solvents (crude oil 49.8 g g−1, soya bean oil 62.3 g g−1, chloroform 71.3 g g−1 etc.). The corresponding cyclic tests showed the absorption capacity decreased slightly from 94.66% to 93.82% after 10 consecutive cycles, indicating a high recyclability.
Ablation of NTPDase2+ cells inhibits the formation of filiform papillae in tongue tip

Lingual epithelia in the tongue tip are among the most rapidly regenerating tissues, but the mechanism of cell genesis in this tissue is still unknown. Previous study has suggested the existence of multiple stem cell pools in lingual epithelia and papillae. Like K14+ and Sox2+ cells, NTPDase2+ cells have characteristics of stem cells.
How accurately do behavioural observations predict reproductive success in free-ranging lizards?

Behavioural ecologists often use data on patterns of male–female association to infer reproductive success of free-ranging animals. For example, a male seen with several females during the mating season is predicted to father more offspring than a male not seen with any females. We explored the putative correlation between this behaviour and actual paternity (as revealed by microsatellite data) from a long-term study on sand lizards (Lacerta agilis), including behavioural observations of 574 adult males and 289 adult females, and paternity assignment of more than 2500 offspring during 1998–2007. The number of males that contributed paternity to a female's clutch was correlated with the number of males seen accompanying her in the field, but not with the number of copulation scars on her body. The number of females that a male accompanied in the field predicted the number of females with whom he fathered offspring, and his annual reproductive success (number of progeny). Although behavioural data explained less than one-third of total variance in reproductive success, our analysis supports the utility of behavioural-ecology studies for predicting paternity in free-ranging reptiles.
Assessment of distortion in watermarked geospatial vector data using different wavelets

With the rapid growth of the Internet, the copyright protection problem occurs frequently, and unauthorized copying and distributing of geospatial data threaten the investments of data producers. Digital watermarking is a possible solution to solve this issue. However, watermarking causes modifications in the original data resulting in distortion and affects accuracy, which is very important to geospatial vector data. This article provides distortion assessment of watermarked geospatial data using wavelet-based invisible watermarking. Eight wavelets at different wavelet decomposition levels are used for accuracy evaluation with the help of error measures such as maximum error and mean square error. Normalized correlation is used as a similarity index between original and extracted watermark. It is observed that the increase in the strength of embedding increases visual degradation. Haar wavelet outperforms the other wavelets, and the third wavelet decomposition level is proved to be optimal level for watermarking.
Energy-Aware Task Allocation for Heterogeneous Multiprocessor Systems by Using Integer Linear Programming

Energy-aware task allocation of embedded systems is one of the most important issues in recent decades. A classical solution to solve the issue is Integer Linear Programming (ILP). However, given the considerable time consumption, it is effective only to the extent that the scale of the problem is small. How to use ILP to solve large allocation problems on heterogeneous multiprocessor systems to minimize energy consumption is still a challenge. This paper proposes two ILP formulations to deal with it. One complete ILP(1) is used to derive a feasible allocation, and the other simplified ILP(2) is for calculating the desired minimum energy. Then the desired minimum energy can be used as a reference to evaluate the intermediate solution of ILP(1) and decide its timeout. Besides, to find out the bestsuited platform for a given workload, a flexible design which presents flexibilities and choices in core assignment, is considered for further energy saving. For example, the optimal core number design and core type design are generated as two independent ILP formulations, denoted as ILP(3) and ILP(4). The experimental results on randomly generated task sets demonstrate that, compared with the fixed platform, automatically synthesizing a flexible core assignment saves more energy.
An Efficient Fingerprint Matching by Multiple Reference Points

This paper introduces an efficient fingerprint matching method based on multiple reference minutiae points. First, we attempt to effectively align two fingerprints by employing multiple reference minutiae points. However, the corresponding minutiae points between two fingerprints are ambiguous since a minutia of one fingerprint can be a match to any minutia of the other fingerprint. Therefore, we introduce a novel method based on linear classification concept to establish minutiae correspondences between two fingerprints. Each minutiae correspondence represents a possible alignment. For each possible alignment, a matching score is computed using minutiae and ridge orientation features and the maximum score is then selected to represent the similarity of the two fingerprints. The proposed method is evaluated using fingerprint databases, FVC2002 and FVC2004. In addition, we compare our approach with two existing methods and find that our approach outperforms them in term of matching accuracy, especially in the case of non-linear distorted fingerprints. Furthermore, the experiments show that our method provides additional advantages in low quality fingerprint images such as inaccurate position, missing minutiae, and spurious extracted minutiae.
Interpersonal Psychotherapy: A Scoping Review and Historical Perspective (1974–2017)

Background Interpersonal Psychotherapy (IPT) is an affect- and relationally focused, time-limited treatment supported by research spanning >4 decades. IPT focuses on stressful interpersonal experiences of loss, life changes, disputes, and social isolation. It emphasizes the role of relationships in recovery. This scoping review describes, within a historical perspective, IPT’s evolution as an evidence-supported treatment of psychiatric disorders. Methods English-language publications (n = 1119) identified via EMBASE, MEDLINE, PsycINFO, and Web of Science databases (1974–2017), augmented with manual reference searches, were coded for clinical focus, population demographics, format, setting, publication type, and research type. Quantitative and qualitative analyses identified IPT publications’ characteristics and trends over four epochs of psychotherapy research. Results IPT literature primarily focused on depression (n = 772 articles; 69%), eating disorders (n = 135; 12%), anxiety disorders (n = 68; 6%), and bipolar disorder (n = 44; 4%), with rising publication rates and numbers of well-conducted randomized, controlled trials over time, justifying inclusion in consensus treatment guidelines. Research trends shifted from efficacy trials to effectiveness studies and population-based dissemination initiatives. Process research examined correlates of improvement and efficacy moderators. Innovations included global initiatives, prevention trials, and digital, web-based training and treatment. Conclusion Sparked by clinical innovations and scientific advances, IPT has evolved as an effective treatment of psychiatric disorders across the lifespan for diverse patients, including underserved clinical populations. Future research to elucidate mechanisms of change, improve access, and adapt to changing frameworks of psychopathology and treatment planning is needed. IPT addresses the universal centrality of relationships to mental health, which is as relevant today as it was over 40 years ago.
Neuroinflammation in the Developing Brain: Risk Factors, Involvement of Microglial Cells, and Implication for Early Anesthesia

Microglia cells, the resident macrophages of the central nervous system, are key actors for specific brain functions that are critical for development and health. Microglial reactivity and functions, even when immature, play a major role if the developing brain is subjected to abnormal perinatal events. Brain exposure to general anesthesia, surgery, or analgesic drugs during early infancy may adversely affect its maturation and plasticity after injury. A better understanding of the regulation of microglial activation in the developing brain and interactions with specific anesthetic drugs is expected to give novel insights into the mechanisms underlying their potential adverse effects. This review recapitulates the most frequent perinatal circumstances associated with exacerbated systemic inflammation and neuroinflammation together with the double-edged role of microglia associated with subsequent brain damage. A role for microglial reactivity in both potential anesthetic toxicity and neuroprotection is emerging. However, further preclinical experiments are needed to better understand regulatory mechanisms of the developing microglia, and interaction between anesthesia and neuroinflammation in the developing brain.
Mathematical model of the risk of drug error during anaesthesia: the influence of drug choices, injection routes, operation duration and fatigue

The incidence of an anaesthetic drug error can be directly observed in large trials. In an alternative approach, we developed a probabilistic mathematical model in which the anaesthetist is modelled as a ‘fallible entity’ who makes repeated drug administration choices during an operation. This fallibility was factored in the model as an initial ‘intrinsic error rate’. The choices faced included: dose; timing of administration; and the routes available for injection (e.g. venous, arterial, epidural, etc.). Additionally, we modelled the effect of fatigue as a factor that magnifies the cumulative error rate. For an initial intrinsic error rate of 1 in 1000 (which from first principles we consider a reasonable estimate), our model predicted a cumulative probability of error over a ~12 h operation of ~10%; that is, 1 in 10 operations this long results in some drug error. This is similar to the rate reported by large observational trials. Serious errors constitute a small fraction of all errors; our model predicts a Poisson distribution for the uncommon serious errors, also consistent with independent observations. Even modest assumptions for the development of fatigue had a dramatic and adverse impact on the cumulative error rate. The practice implications of our modelling include: exercising caution or avoiding starting work if under par; added vigilance in unfamiliar environments; keeping anaesthetic recipes simple; and recognising that operation durations > 5–6 h constitute a time of exaggerated risk. These implications are testable predictions in observational trials. If validated, our model could serve as a potential research tool to investigate the impact of safety interventions on the rate of intrinsic error using simulation.