Miracle-dz/UniFAR-FTUs huggingface dataset:
Disfunção vascular e autonômica cardíaca em pacientes com diabete melito tipo 1

In the present study, we observed that the submaximal heart rate (HR) in patients with nephropathy and retinopathy (considering the mean age of the groups shown in Tables 1 and 2, minus 195) was 154 bpm. However, these patients reached submaximal HR of 148 bpm. Thus, we would like to know if the stress test used in patient selection also gave rise to the submaximal HR data that were used in data analysis, or if two exercise tests were performed. Was the documentation of absence of coronary artery disease made only based on the selection stress test as shown in Tables 1 and 2? If so, were the results the same when excluding patients with coronary artery disease?
Community-based matrix factorization for scalable music recommendation on smartphones

Mobile karaoke has attracted more attention as a popular mobile entertainment and social network platform, where music recommendations are highly desired to improve its user experiences. Traditional music recommendation methods suffer from the data sparsity issue and usually ignore the social interactions among users. In this paper, we propose a novel parallel community-based matrix factorization method which exploits implicit user behavior data to model user preferences from both social level, via community detection, and individual level. Both offline evaluation on a real dataset from Changba and online traffic investigations show the effectiveness of our method.
Cost-effectiveness of implementing automated grading within the national screening programme for diabetic retinopathy in Scotland

Aims: National screening programmes for diabetic retinopathy using digital photography and multi-level manual grading systems are currently being implemented in the UK. Here, we assess the cost-effectiveness of replacing first level manual grading in the National Screening Programme in Scotland with an automated system developed to assess image quality and detect the presence of any retinopathy. Methods: A decision tree model was developed and populated using sensitivity/specificity and cost data based on a study of 6722 patients in the Grampian region. Costs to the NHS, and the number of appropriate screening outcomes and true referable cases detected in 1 year were assessed. Results: For the diabetic population of Scotland (approximately 160 000), with prevalence of referable retinopathy at 4% (6400 true cases), the automated strategy would be expected to identify 5560 cases (86.9%) and the manual strategy 5610 cases (87.7%). However, the automated system led to savings in grading and quality assurance costs to the NHS of £201 600 per year. The additional cost per additional referable case detected (manual vs automated) totalled £4088 and the additional cost per additional appropriate screening outcome (manual vs automated) was £1990. Conclusions: Given that automated grading is less costly and of similar effectiveness, it is likely to be considered a cost-effective alternative to manual grading.
Recombinant Activated Factor VII for the Rapid Correction of Coagulopathy in Nonhemophilic Neurosurgical Patients

OBJECTIVECoagulopathy is a significant contraindication for neurosurgery. Unfortunately, many coagulopathic patients require urgent neurosurgical intervention. Standard use of blood products, including fresh-frozen plasma or prothrombin complexes, to correct the coagulopathy often leads to significant delays in treatment. Recombinant activated factor VII (rFVIIa) is a medication originally designed to treat bleeding in hemophiliacs but also seems to correct a wide variety of coagulopathies rapidly and safely in nonhemophilic patients. METHODSThe medical records of nine patients with coagulopathy requiring urgent neurosurgical intervention were reviewed retrospectively. Each patient was given a dose ranging from 40 to 90 &mgr;g/kg of rFVIIa before undergoing surgery. Pre-rFVIIa coagulation and post-rFVIIa coagulation parameters were obtained. Once correction of the coagulopathy was verified, each patient underwent the appropriate neurosurgical procedure. RESULTSThe average age of the patients was 40.9 years; six were women. The causes of the coagulopathy included anticoagulant medication, liver dysfunction, and dilutional coagulopathy after traumatic hemorrhage. Neurosurgical indications included intraparenchymal/intraventricular hemorrhage, hydrocephalus, diffuse cerebral edema, and epidural hematoma. Post-rFVIIa coagulation parameters obtained as early as 20 minutes after infusion of the medication showed normalization of values. There were no procedural or operative complications and no postoperative hemorrhagic complications. No associated thromboembolic or other complications with the use of rFVIIa were observed. CONCLUSIONThe use of rFVIIa for the urgent surgical treatment of coagulopathic patients is quite promising. Further studies, including randomized, prospective trials using rFVIIa to address issues such as optimal dosing, efficacy, surgical indications, cost-effectiveness, morbidity, and mortality are needed.
Genotype-guided diagnosis in familial hypercholesterolemia: population burden and cascade screening

Purpose of review In this review, how genetic testing has provided major new insights regarding the population burden of familial hypercholesterolemia (FH) are reviewed. In addition, the role of genetic testing in cascade screening for FH and an updated MEDPED (Make Early Diagnoses to Prevent Early Death in MEDical PEDigrees) algorithm for the clinical diagnosis of FH are presented. Recent findings For the first time, recent application of genetic testing for FH in large populations has provided firm estimates of the prevalence of FH (at least one in 220) in the USA. High associated risks of coronary artery disease make FH the most common genetic cause of premature coronary artery disease. Summary Genetic testing has yielded accurate, new estimates of the population burden of FH. The potential benefits of early diagnosis of FH on a population-wide level have not yet begun to be realized.
Notes on Some Literature in Experimental Economics

These notes provide a guide and some comments on a portion of the literature of experimental economics. They represent thoughts and criticisms developed in the course of a seminar in experimental economics at Purdue University. The references do not constitute an extensive bibliography. For an excellent summary of the experimental oligopoly literature, the interested reader is urged to consult Friedman [1969], and for additional general discussion of the scope and significance of experimental economics and for further bibliographic references, see Naylor [1972].
Proceedings of the Third Workshop on Statistical Machine Translation

The ACL 2008 Workshop on Statistical Machine Translation (WMT-08) took place on Thursday, June 19 in Columbus, Ohio, United States, immediately following the annual meeting of the Association for Computational Linguistics, which was hosted by the Ohio State University. This is the third time this workshop has been held. It has its root in the ACL 2005 Workshop on Building and Using Parallel Texts In the following years the Workshop on Statistical Machine Translation was held at HLT-NAACL 2006 in New York City, US, and at ACL 2007 in Prague, Czech Republic. The focus of our workshop was to use parallel corpora for machine translation. Recent experimentation has shown that the performance of SMT systems varies greatly with the source language. In this workshop we encouraged researchers to investigate ways to improve the performance of SMT systems for diverse languages, including morphologically more complex languages and languages with partial free word order. Prior to the workshop, in addition to soliciting relevant papers for review and possible presentation we conducted a shared task that brought together machine translation systems for an evaluation on previously unseen data. This year's task resembled the shared tasks of previous years in many ways, but also included Hungarian-English and Spanish-German as new language pairs. In addition, we evaluated submitted systems against new test sets from the newswire domain. The results of the shared task were announced at the workshop, and these proceedings also include an overview paper for the shared task that summarizes the results, as well as provides information about the data used and any procedures that were followed in conducting or scoring the task. In addition, there are short papers from each participating team that describe their underlying system in some detail. Due to the large number of high quality submission for the full paper track, shared task submissions were presented as posters. The poster session was held in the afternoon and gave participants of the shared task the opportunity to present their approaches. The rest of the day was devoted to oral paper presentations and Daniel Marcu's invited talk in the afternoon. Like in previous years, we have received a far larger number of submission than we could accept for presentation. This year we have received 18 full paper submissions and 26 shared task submissions. In total WMT-08 featured 12 full paper oral presentations and 25 shared task poster presentations. The invited talk was given by Daniel Marcu of the Information Sciences Institute at the University of Southern California.
Atrial natriuretic factor and renal function during head-out water immersion in conscious dogs.

The potential role of atrial natriuretic factor (ANF) in the renal response to head-out water immersion (WI) was studied. Five female mongrel dogs, trained to stand for 100 min in air followed by 100 min of thermoneutral WI at 37 degrees C or 200 min in air (timed control, TC), were chronically instrumented with arterial and venous catheters. The animals were hydrated with a volume of 0.45% NaCl solution equivalent to 2% of their body weight. Prehydration levels of arterial ANF were 243 +/- 15 (SE), and venous ANF levels were 211 +/- 21 pg/ml. WI resulted in an increase in urine flow from 0.7 +/- 0.1 ml/min to a peak flow of 2.2 +/- 0.3 ml/min (P less than 0.05). On immersion, plasma venous and arterial ANF levels increased significantly by 29 and 21% from the preimmersion values of 183 +/- 14 and 222 +/- 20 pg/ml, respectively. The arterial-venous difference for plasma ANF was maintained at 35 +/- 14 pg/ml (P less than 0.05) during WI; therefore venous sampling may suffice as a measure of circulating ANF levels. Sodium excretion increased linearly during WI to a peak value of 228 +/- 32 mu eq/min from a base line of 52 +/- 12 mu eq/min (P less than 0.05). These data indicate that peripheral tissues extract ANF and that WI is a physiological stimulus for the release of ANF. However, the time course and magnitude of the changes in plasma ANF and urine sodium excretion during WI are not comparable, and other mechanisms are likely responsible for the WI natriuresis. (ABSTRACT TRUNCATED AT 250 WORDS)
The long-term consequences of parental divorce for children’s educational attainment

Background: In this paper we study the long-term consequences of parental divorce in a comparative perspective. Special attention is paid to the heterogeneity of the consequences of divorce for children’s educational attainment by parental education. Objective: The study attempts to establish whether the parental breakup penalty for tertiary education attainment varies by socioeconomic background, and whether it depends on the societal context. Methods: Data are drawn from the first wave of the Generations and Gender Survey, covering 14 countries. We estimate multi-level random-slope models for the completion of tertiary education. Results: The results show that parental divorce is negatively associated with children’s tertiary education attainment. Across the 14 countries considered in this study, children of separated parents have a probability of achieving a university degree that is on average seven percentage points lower than that of children from intact families. The breakup penalty is stronger for children of highly educated parents, and is independent of the degree of diffusion of divorce. In countries with early selection into educational tracks, divorce appears to have more negative consequences for the children of poorly educated mothers. Conclusions: For children in most countries, parental divorce is associated with a lower probability of attaining a university degree. The divorce penalty is larger for children with highly educated parents. This equalizing pattern is accentuated in countries with a comprehensive educational system. Comments: Future research on the heterogeneous consequences of parental divorce should address the issue of self-selection into divorce, which might lead to an overestimation of the negative effect of divorce on students with highly educated parents. It should also further investigate the micro mechanisms underlying the divorce penalty.
Aneurysmal subarachnoid hemorrhage: management strategies and clinical outcomes in a regional neuroscience center.

BACKGROUND AND PURPOSE Aneurysmal subarachnoid hemorrhage (SAH) affects six to eight people per 100,000 annually, yet the optimum management of this condition remains controversial. Although the International Subarachnoid Aneurysm Trial (ISAT) explored this area, only 28% of patients from our center were randomized in that study. Our purpose was to evaluate the treatment and outcomes of patients not recruited into ISAT. METHODS Procedural data, adverse events, additional procedures, and length of hospital stay were recorded for 122 patients who came to our center with aneurysmal SAH. Modified Rankin Scale (MRS) was assessed at 2 months and at 1 year by a postal questionnaire and telephone interview. RESULTS Nine patients were treated conservatively, 67 underwent surgical clipping, and 46 underwent endovascular therapy. At 2 months, a good grade (MRS 0-2) was achieved in 67% of patients treated with endovascular therapy and in 45% of patients treated with surgery. At 1 year, a good grade was achieved in 72% in the endovascular group and 49% in the surgical group. CONCLUSION Endovascular therapy was a safe and effective treatment in a series of subjects who were not randomized in ISAT and in whom endovascular therapy was chosen over surgical clipping. The outcomes at 2 months and 1 year for those subjects treated with endovascular therapy were superior to the outcomes in those treated with surgical clipping. Our study was small and from a single center, but in this population the outcomes of endovascular treatment were similar to those reported by ISAT.
PASSAGE OF GLIADIN INTO HUMAN BREAST MILK

Cow's milk proteins and ovalbumin have been recently identified in human breast milk(1). The aim of this investigation was to determine whether wheat gliadin is also present in human milk. Following the ingestion of a test meal of 20 g gluten, samples of breast milk were collected from 53 women at various stage of lactation.Gliadin was assessed by a double-antibody sandwich ELISA and 5 ng/ml or more could be measured in this way. Despite the presence of specific antibodies, prechallenge milk did not inhibit significantly the ELISA.After ingestion, gliadin was detected in breast milk from 41/53 women at 1 week after delivery, 8/17 at 6 weeks, 3/6 at 3 months and 2/4 at 5 months. The gliadin concentration ranged from 5 to 95ng/ml. Maximum levels in breast milk were found 2-4 hours after ingestion; however, gliadin could not be detected simultaneously in serum.The transfer of gliadin from mother to child early in his life might be critical for the development in later life of an appropriate specific immune response.1)Kilshaw P.J.:Int.Archs Allergy appl.Immun. 75, 8-15,1984.
Temozolomide chemotherapy of patients with recurrent anaplastic astrocytomas and glioblastomas.

INTRODUCTION Anaplastic astrocytomas and glioblastomas are the most frequent and most malignant hemispherial tumours. Unfortunately, astrocytic tumours are of infiltrative character and radical removal is not possible. Recurrent malignant gliomas are rarely suitable for reoperation. In most of the cases of recurrent gliomas chemotherapy is the last choice. PATIENTS AND METHOD Seventy-five consecutive patients with recurrent malignant astrocytomas and glioblastomas had been treated at our institute with per os temozolomide for five days every month. The patients received two to 16 courses of chemotherapy. The toxicity, quality of life, response to chemotherapy and survival data were analysed. RESULTS Out of 75 patients four were excluded following the first treatment due to myelotoxicity, and allergic reactions. Among the patients treated with temozolomide in seven cases complete response, 17 partial response, 14 progressive disease were observed. In 33 cases the disease stabilized and out of them in 27% a significant neurological improvement was detected. The time to progression was 6.8 months and the median survival time 8.75 months for patients with glioblastoma and with malignant astrocytoma or malignant mixed oligoastrocytoma 9.45 and 11.15 months, respectively. The overall survival for patients with originally lower grade glioma was 70.32 and for patients with glioblastoma multiforme 17.43 months. CONCLUSIONS Temozolomide chemotherapy in patients with recurrent malignant astrocytoma and glioblastoma proved to be efficacious and similar good results were achieved as with a nitrosourea based combined chemotherapy. Even in those patients who received previous chemotherapy temozolomide is well tolerated and a relatively long time to progression was achieved in cases of recurrent malignant gliomas. In a few number of patients where BCNU had been previously failed with temozolomide stable disease was achieved. Temozolomide seems to be a promising drug in the chemotherapy of malignant gliomas and can be applied as a second line chemotherapy, as well.
Confirming Two Conjectures About the Integer Partitions

For a given integer n, let ? n denote the set of all integer partitions ? 1? 2? m>0 (m? 1), of n. For the dominance order “? ” on ? n, we show that if two partitions ? , ? are both chosen from ? n uniformly at random, and independent of each other, then Pr(? )? 0 as n? ∞. This statement answers affirmatively a question posed by Macdonald in 1979. The proof is based on the limit joint distribution of the largest parts counts found by Fristedt. A slight modification of the argument confirms a conjecture made by Wilf in 1982, namely that, for n even, the probability of a random partition being graphical is zero in the limit. The proof of the latter follows the footsteps of Erdos and Richmond who saw that to confirm Wilf's conjecture it would be sufficient to show that the probability of the first k Erdos? Gallai conditions of a partition being graphical approaches 0 as n, and then k approach infinity. The reason that the proofs of two seemingly unrelated conjectures turned out to be so close is that, as the E-R analysis revealed, the (joint) distribution of the largest part sizes in a partition ? and its dual ? coincides, in the limit, with the distribution of the largest part sizes for two independent partitions.
Nanocomposites-a review of electrical treeing and breakdown

In this short review, we discussed some aspects of nanocomposites regarding electrical tree growth and breakdown. It appears that nanoparticles, properly mixed and dispersed in the polymer matrix, increase the breakdown strength and hinder the growth of electrical trees in the nanocomposite. Nanoparticles act as barriers obstructing electrical tree growth and delaying dielectric breakdown. This article also put forward a tentative proposal for the mechanisms of treeing and breakdown in nanocomposites.
Impact of the activity calculation method used in transarterial radioembolization: a dosimetric comparison between 90Y-SIRSphere and 90Y-TheraSphere therapy

PurposeTransarterial radioembolization is used to treat primary and secondary liver malignancies. Two commercially available drugs are utilized for the purpose. The aim of our study is to compare the radiation dose delivered to the tumor by these drugs. Materials and methodsThis study included 86 patients (M : F – 7.6 : 1, median age=50.5 years), 46 patients were treated by 90Y-TheraSphere and 42 patients were treated by 90Y-SIRSphere. Activity administered in 90Y-TheraSphere and 90Y-SIRSphere was calculated using a modified partition model and a modified body surface area model, respectively. The radiation dose delivered by two drugs was calculated and compared in our study. ResultActivity administered in 90Y-TheraSphere was significantly higher than that of 90Y-SIRSphere. Hence, the radiation dose delivered to the tumor by 90Y-SIRSphere was significantly lower (58.4%) than that of 90Y-TheraSphere (P=0.000). ConclusionAs the radiation dose delivered by 90Y-SIRSphere was lower than 90Y-TheraSphere, we believe that the formula for 90Y-SIRSphere activity calculation needs to be modified so that the optimal dose can be delivered to the tumor.
Structural Diversity of Eukaryotic Membrane Cytochrome P450s*

X-ray crystal structures are available for 29 eukaryotic microsomal, chloroplast, or mitochondrial cytochrome P450s, including two non-monooxygenase P450s. These structures provide a basis for understanding structure-function relations that underlie their distinct catalytic activities. Moreover, structural plasticity has been characterized for individual P450s that aids in understanding substrate binding in P450s that mediate drug clearance.
Digital regulatory tools for entrepreneurial and creative behavior in the knowledge economy

The paper provides conceptual analysis of creative and entrepreneurial behavior in digital economy. Despite recent advances in statistical inference, the casual interpretation of models that try to predict behavior based on observational data can be dangerous. Causal interpretation can result in reproducing and amplifying unwanted social phenomena e.g. stigmatization. Thus, the information security systems shall be built on the basis of experimental analysis of human behavior, ethical considerations, and take into account the further long-term outcomes from the regulatory tools within the automated digital environment and smart spaces.
THE COSMIC ABUNDANCES OF POTASSIUM, URANIUM, AND THORIUM AND THE HEAT BALANCES OF THE EARTH, THE MOON, AND MARS.

by the homogeneous behavior of native and enzymatically liberated maple lignins in electrophoresis, as contrasted with the indication of a secondary component in both these lignins by the paper-chromatographic technique. As a result of this study, lignins should be regarded as mixtures of components, all possessing similar structures but with the possibility of certain chemical differences, as discussed above. It is for such mixtures of substances which may differ both in structure and in molecular size that Staudinger introduced the term Gruppenstoffe. 12
A Compact Tunable Notch Filter With Wide Constant Absolute Bandwidth

A compact notch filter with a wide tunable frequency range is developed. This tunable filter is composed of two varactor-tuned resonators, shunted at input/output ports separately, and one quarter-wavelength transmission line connecting two varactor-tuned resonators. By enlarging impedance of the quarter-wavelength transmission line, the proposed tunable filter can obtain a wide and constant absolute bandwidth within the whole tunable frequency band. The measured results show that there is a wide tuning range, 124.3%. In addition, with insertion loss greater than 20 dB, a wide constant absolute bandwidth can be achieved at 450 MHz.