Miracle-dz/UniFAR-FTUs huggingface dataset:
Altered cooperativeness in patients with polycystic ovary syndrome

ABSTRACT OBJECTIVE: In the present study, we aimed to compare temperament and character traits between patients with polycystic ovary syndrome (PCOS) and age-body mass index-matched healthy controls (HC). We hypothesized that patient with PCOS would differ in terms of temperament and character traits compared with HCs. MATERIAL AND METHODS: Fifty patients who were diagnosed with PCOS and 42 age-body mass index-matched healthy controls (HC) were included in the study. The groups were compared in terms of temperament and character traits and anxiety status with the Temperament and Character Inventory (TCI) and State-Trait Anxiety Inventory (STAI-1 and STAI-2). FINDINGS: There was a statistically significant difference between patient and the control group in terms of cooperativeness dimension (t = −2.81; p = 0.006). It was a lower mean in the PCOS group (20.98 2.992). In addition, scores of STAI-1 and STAI-2 were significantly higher in the PCOS group compared with the HC group (respectively; t = 5.70; p < 0.001; t = 2.12; p = 0.037). The score of cooperativeness and multivariate analysis of variance was found to be significantly lower in the PCOS group. CONCLUSIONS: Patients with PCOS had significant a different character trait such as lower cooperativeness compared with HC. Additionally, we found that this different character dimension would be a trait in PCOS after covariant analysis. We suggest that our result supported the psychiatric background of PCOS.
An open label phase II study of modified vaccinia ankara (MVA) expressing the tumor antigen 5T4 given in conjunction with chemotherapy: Safety and immunogenicity before, during and after chemotherapy

2578 Background: 5T4 is a tumour associated antigen that is widely expressed on the surface of most human adenocarcinomas, including colorectal, but rarely in normal cells. Modified Vaccinia Ankara (MVA) has been employed as a vaccine vector to deliver 5T4 (TroVax). Previously, TroVax has been evaluated in a phase I/II clinical trial in Duke’s D colorectal cancer patients. TroVax was shown to be safe and well tolerated and induced 5T4 specific immune responses in most patients. Furthermore, periods of disease stabilisation up to 18 months were observed. Methods: Two phase II clinical trials were initiated in which TroVax was administered in conjunction with either 5-FU/leukovorin and irinotecan (TV2-Irinotecan trial) or 5-FU/leukovorin and oxaliplatin (TV2-Oxaliplatin) in patients with advanced colorectal cancer. Both trials are open label and entail the administration of up to 6 injections of TroVax, 2 prior to, 2 during and 2 post-chemotherapy. The primary objective is to assess the effect of repeat cyc.
La médecine peut-elle nuire à la santé des médecins?

Les medecins exercent une profession singuliere, qui comporte des risques psychosociaux specifiques. Dans le contexte actuel de debat sur la souffrance au travail, nous nous sommes interesses a ceux de nos confreres qui traversent des crises personnelles et/ou professionnelles. Qui sont ces praticiens qui se suicident ? Existe-t-il des facteurs associes ? Quelle est la part de l'epuisement pro fessionnel ? Les internes rencontrent-ils deja les memes difficultes que leurs aines ? Enfin, est-il possible de prevenir ces drames ?
The contribution of agricultural biodiversity to food security in an indigenous community in the Huasteca Potosina, Mexico

While global food production greatly exceeds dietary energy demand, undernutrition remains, and diets largely fail to ensure the health of the population. Agricultural biodiversity is crucial for the world’s food security, but genetic diversity has been degraded. In Mexico, the dietary transition towards processed foods has contributed to malnutrition and a rise of diet-related chronic diseases. Mexico’s indigenous people are conserving and creating valuable plant genetic resources in their swidden milpas and traditional agroforestry systems but remain the country’s most vulnerable population group. The Teenek (or Huastec), an indigenous group that habitat the Huasteca Potosina, a region in north-eastern Mexico cultivate a high diversity of edible plants in their home gardens (solar), milpas, and agroforestry systems (te’lom, or finca). However, migration has been leading to the abandonment of traditional farming in the region. The objective of this study was to analyse if the managed agricultural biodiversity of the different traditional land use systems contributes to the food security of the farming households in the community of Jol Mom. Food availability and access were investigated. In total, 40 households were surveyed. Dietary patterns were identified through principal component analysis. Informal interviews, semi-structured interviews and participant observation allowed to account for the people’s own perceptions and provided additional insights. Findings showed that traditional Teenek farming systems are the source of a variety of nutritious foods and resulted to be the most important provider of fruits and vegetables. The average production diversity was 34 out of 56 crops, farmers cultivating more than one or two farming systems showed an increase of four and 11 produced species respectively. Production diversity was strongly correlated with food variety in a household’s diet, with an increment of one per 0.85 produced crop. Two main diverging dietary patterns were revealed, a westernized diet relying largely on purchased foods, to which the younger generation was more inclined, and a traditional diet characterized by a high consumption of cultivated products, mostly observed in the older households. In conclusion, farming households in Jol Mom profit from the agricultural diversity of their production systems, either through the consumption of nutritious foods or by the sale of agricultural products. However, a tendency towards nutrient-poor diets was observed. Increasing agricultural diversity and consumption of locally produced foods might help to fight this trend but would require a valorisation of traditional foods and an appreciation of the contribution of indigenous people’s traditional agriculture to food security.
A Rare Case Of Candida Tenosynovitis Successful Suppressed With Voriconazole After Fluconazole Failure. Case Report And Review Of Literature

A 69-year-old patient presented with a Candida albicans bilateral tenosynovitis of the extensor digitorum muscles. Haematogenous spread was most likely as no trauma for direct inoculation was apparent, while he had been treated for Candida spondylodiscitis one year before. Although initial fungigram on the synovial fluid demonstrated susceptibility for fluconazole, therapy with fluconazole failed after in vivo resistance to fluconazole developed. Treatment with voriconazole was able to induce complete resolution of the tenosynovial inflammation without surgery. However, late recurrence occurred when voriconazole was stopped, possibly because of cross-resistance between fluconazole and voriconazole. Longterm oral therapy with voriconazole was able to supress the infection.
Thérapie cellulaire myocardique par administration de myoblastes squelettiques

J uin 2005 a marqué le cinquième anniversaire de la première greffe intramyocardique de myoblastes squelettiques chez l’homme (1). Cette intervention a représenté tout autant l’aboutissement de plus de dix ans de travaux expérimentaux et le début d’une période d’intense activité clinique allant de pair avec la poursuite d’études chez l’animal, non plus tant pour démontrer l’efficacité fonctionnelle de la procédure que pour tenter d’en comprendre les mécanismes. Le temps est donc venu de dresser un premier bilan, de définir les principaux obstacles que l’expérience initiale a permis d’identifier, et de tracer quelques perspectives.
Institutional Organization of Resource-Type Regions in Russia: General Description and Structural Shift in the Economy

В данной статье дается характеристика институциональной организации регионов ресурсного типа. При этом обосновываются сравнительные преимущества политикоэкономического подхода к этой проблеме, базирующегося на выделении дискретных структурных (институциональных) альтернатив их развития. Предложенный подход позволяет охарактеризовать взаимосвязь между ресурсно-отраслевой структурой экономики, институциональной организацией рынков и конституционным устройством экономики и социума. Выбор между этими альтернативами выступает как результат взаимодействия между доминирующими политико-экономическими акторами, мотивация и ограничения деятельности которых рассматриваются в контексте действия эффектов исторической обусловленности развития и блокировки. Эффект исторической обусловленности развития проявился в наличии особых форм взаимосвязи между специфической ресурсно-отраслевой структурой экономики и политикоэкономической организацией общества, построенной на дополнении горизонтальных
Optimal Model-Free Output Synchronization of Heterogeneous Multiagent Systems Under Switching Topologies

In this article, the output synchronization of discrete-time heterogeneous multiagent systems over directed switching topologies is investigated. For output synchronization problem, the optimal control protocols for all agents depend on the solutions of a series of algebraic Riccati equations (AREs), which are difficult to be solved analytically. Besides, both the agents’ and the leader's dynamics are supposed to be unknown. The distributed adaptive observer for each agent is designed first to estimate the leader's state without requiring complete knowledge of the leader's dynamics. Based on the trained observers, the output synchronization problem is formulated to an optimal control problem. An observer-based Q-learning algorithm is developed to solve the AREs using system data rather than the accurate system models. The optimal analytic distributed control policies can be obtained by policy iteration combined least square method. It is proved theoretically that the output synchronization is ensured based on the distributed adaptive observers under switching topologies. Ultimately, the theoretical results are demonstrated via three simulation examples.
Thyroïde et grossesse

La frequence de la pathologie thyroidienne chez la femme jeune confronte regulierement l'obstetricien au suivi de la grossesse de patientes ayant une dysthyroidie. De severite variable, les potentielles repercussions foeto-maternelles du dysfonctionnement thyroidien pendant la grossesse justifient une etroite collaboration entre obstetricien et endocrinologue afin d'assurer aux patientes une prise en charge precoce et adaptee.
Epidemiological, Virological and Clinical Characteristics of Hepatitis B Virus Genotypes in Chronically Infected Persons in Slovenia

Background: Hepatitis B virus (HBV) genotypes have been shown to have virological, clinical, and therapeutic implications. Knowledge about HBV genotype distribution in Slovenia is scarce. This study was the first to determine various characteristics of patients with chronic HBV infection with regard to HBV genotypes at the national level. Methods: HBV genotype determination was performed on randomly selected patients out of 1,729 patients from all Slovenian regions who tested positive for HBV surface antigen (HBsAg) at the national reference laboratory for viral hepatitis between January 1997 and December 2010. Demographic, epidemiological, virological, and clinical data were extracted from the medical records and statistically analyzed with regard to HBV genotypes. Results: A total of 186 HBsAg positive patients with the mean age of 40.1 years were identified from whom, 65.1% were male. 157 (84.4%) cases presented with genotype D, 23 (12.4%) with genotype A, and 6 (3.2%) with other HBV genotypes. Sexual transmission was more significantly associated with lower odds for HBV genotype D infection compared to blood-related risk factors (P = 0.023). Genotype A was significantly more common in men who had sex with men (P = 0.043). Compared to females with genotype D, genotype A positive women presented unknown risk factors more significantly (P = 0.002). Conclusions: HBV genotype D is the most prevalent genotype in Slovenia. However, future changes might be expected due to recent massive immigrations to Europe. Routine HBV genotyping is recommended in patients with certain risk factors prior to initiation of hepatitis B treatment.
Determination of selected components in seminal plasma of donkey stallions and their correlation to semen quality parameters

Evaluation of selected components of seminal plasma as markers of ejaculate quality may be of interest when assessing the quality of semen. The aim of the study was to evaluate some biochemical parameters of seminal plasma in donkeys and compare them with the volume, concentration and motility of the ejaculate. A total of 11 ejaculates were collected from five donkey stallions (between one and three from each animal). Each ejaculate was assessed for volume, concentration and motility, and the seminal plasma biochemically examined after centrifugation. Total protein, creatinine, urea, alkaline phosphatase (ALP), alanine-amino-transferase (ALT), aspartate-amino-transferase, creatine kinase, gamma-glutamyl-transferase, lactate-dehydrogenase (LDH), sodium, potassium (K+), calcium, phosphate, chloride, copper (Cu), cholesterol, vitamin E (Vit E), magnesium (Mg2+), seminal plasma selenium (Se SP) and seminal plasma zinc (Zn SP) were identified. Biochemical analysis of the seminal plasma was then statistically evaluated using the Spearman coefficient of correlation. A significant positive correlation between ALP, ALT, LDH, Cu, Se SP and Zn SP and sperm concentration was found. Also there was a significant positive correlation between Vit E and sperm motility. Finally, there was a significant positive correlation between urea, K+, Mg2+ and the ejaculate volume. This is the first report about selected biochemical components of donkey's seminal plasma that we know of. However, further research using a larger number of individuals is necessary to confirm that these components of seminal plasma are useful as markers of ejaculate quality in donkey stallions.
The pLoc_bal-mGneg Predictor is a Powerful Web-Server for Identifying the Subcellular Localization of Gram-Negative Bacterial Proteins based on their Sequences Information Alone

Recently a very powerful web-server has been developed for predicting the subcellular localization of Gram-negative bacterial proteins purely according to their sequences information for the multi-label systems, in which a same protein may appear or move between two or more location sites and hence its ID (identification) needs two or more labels for distinction, namely the â€œmulti-label markâ€ . The web-server is called as â€œpLoc_bal-mGnegâ€ , where â€œbalâ€ means that the predictor has been treated by balancing or quasi-balancing out the training dataset [3-9], and â€œmâ€ means that the predictor is with the capacity to study the multi-label systems.
Towards Multi Robot Task Allocation and Navigation using Deep Reinforcement Learning

Developing algorithms for multi robot systems to reach target positions and navigate safely in the environment is an open field of research. Most systems treat Multi Robot Task Allocation (MRTA) and Multi Robot Path Planning (MRPP) as two separate steps each with its own set of algorithms in which the MRTA algorithm assigns each robot to a task and the MRPP algorithm guides each robot through the environment towards the assigned goal position while avoiding both static and dynamic obstacles. In this paper, we present a method that combines both steps by using a deep reinforcement learning model. The model consists of a decentralized sensor level policy which outputs the robot’s velocity to guide it through the environment towards the selected goal position and avoiding collisions. The model was trained in a simulation environment and all the robots are homogenous differential drive robots. The objective is to ensure that each robot reaches a unique goal position with the number of goal positions is equal to the number of robots. The results of training the policy in an environment is presented with both static and dynamic obstacles with four robots and four goal positions.
Consistent Video Style Transfer via Compound Regularization

Recently, neural style transfer has drawn many attentions and significant progresses have been made, especially for image style transfer. However, flexible and consistent style transfer for videos remains a challenging problem. Existing training strategies, either using a significant amount of video data with optical flows or introducing single-frame regularizers, have limited performance on real videos. In this paper, we propose a novel interpretation of temporal consistency, based on which we analyze the drawbacks of existing training strategies; and then derive a new compound regularization. Experimental results show that the proposed regularization can better balance the spatial and temporal performance, which supports our modeling. Combining with the new cost formula, we design a zero-shot video style transfer framework. Moreover, for better feature migration, we introduce a new module to dynamically adjust inter-channel distributions. Quantitative and qualitative results demonstrate the superiority of our method over other state-of-the-art style transfer methods. Our project is publicly available at: https://daooshee.github. io/CompoundVST/.
Individual Differences in Reading Speed are Linked to Variability in the Processing of Lexical and Contextual Information: Evidence from Single-trial Event-related Brain Potentials

In the current paper, we examined the effects of lexical (e.g. word frequency, orthographic neighborhood density) and contextual (e.g. word predictability in the form of cloze probability) features on single-trial event-related brain potentials in a self-paced reading paradigm. Critically, we examined whether individual differences in reading speed modulated single-trial effects on the N400, an ERP component linked to semantic memory access. Consistent with past work, we found that word frequency effects on the N400 were attenuated with increasing predictability. However, effects of orthographic neighborhood density were robust across all levels of predictability. Importantly, individual differences in reading speed moderated the influence of both frequency and predictability (but not orthographic neighborhood density) on the N400, such that slower readers showed reduced effects compared to faster readers. These data show that different lexical factors influence word processing through dissociable mechanisms. Our findings support a dynamic semantic-memory access model of the N400, in which information at multiple levels (lexical, sentential, individual) simultaneously contributes to the unfolding neural dynamics of comprehension.
Mean transport and variability in the subpolar North Atlantic

The Atlantic Meridional Overturning Circulation (AMOC) plays an important role in the Earth’s heat and carbon budgets and sets the properties of the global water masses. Deep water formed in high latitudes, travel southwards as part of the AMOC’s lower limb and have properties that can be traced globally. As the AMOC’s upper limb transports warm water northwards it releases heat to the atmosphere, contributing to the moderate climate of Western Europe and impacts all aspects of high latitudinal climate. In the northern North Atlantic there is a lack of long-term transoceanic measurements, enabling estimate s of the AMOC’s transport variability. For this reason, it is essential that quantification of the AMOC’s mean transports in the subpolar region are as accurate as possible. Furthermore, the possibility of quantifying the AMOC’s variability in this region could improve our understanding of the AMOC’s driving mechanisms. The Extended Ellett Line (EEL) is a repeat hydrographic section located between Iceland and Scotland and is the focus area for this study. This section captures 90% of the water flowing northwards into the Nordic Seas and half the returning dense water; two key parts of the AMOC. Data has been collected near-annually at the EEL since 1996, providing two decades of hydrographic and direct velocity measurements. The first objective of this study is to quantify the long-term averages of the currents that shape the AMOC across the EEL, using direct velocity measurements. Improved estimates of the long-term (1997-2015) mean absolute velocity field and volume, temperature and freshwater transports are presented. Analysis of the time-mean velocity field contributes to knowledge of the location and variability of the currents transporting water northwards. There is evidence that a branch of the North Atlantic Current is located at the Rockall-Hatton Plateau (RHP). The net transport at the EEL is 3.5 ± 0.9 Sv, of which there is 5.9 ± 1.4 Sv in the upper ocean and -3.3 ± 0.7 Sv in the overflow water. There is a temperature transport of 0.22 ± 0.04 PW,
A Novel Tabu Search Algorithm for Multi-AGV Routing Problem

In this paper, we propose a novel tabu search (NTS) algorithm that improves the efficiencies of picking goods of automated guided vehicles (AGVs) in an automatic warehouse by solving the conflicts that happen when multiple AGVs work at the same time. Relocation and exchanging operations are designed for the neighborhood searching process based on each pickup-point’s location in the warehouse, along with the initial solution generation and the termination condition in the proposed algorithm. The experimental results show that the tabu search algorithm can effectively optimize the order of pickup points, which could further reduce the total travel distance and improve the efficiencies of AGVs in automatic warehouses.