Miracle-dz/UniFAR-FTUs huggingface dataset:
Population Pharmacokinetics and Pharmacodynamics of Meropenem in Pediatric Patients

Meropenem is a highly potent carbapenem antibiotic against gram‐positive and gram‐negative bacteria. Meropenem plasma concentration data from 99 pediatric patients (aged 0.08–17.3 years) were used to develop a population pharmacokinetic model. Pharmacokinetic analysis was performed using NONMEM with exponential interindividual variability and combinational residual error model. A 2‐compartment model was found to fit the data best. Creatinine clearance and body weight were the most significant covariates explaining variabilities in meropenem pharmacokinetics among pediatric patients. The validated final model was used to predict meropenem plasma concentrations in 37 pediatric meningitis patients, receiving 40 mg/kg meropenem, who had minimum inhibitory concentration values of the causative pathogens and outcome available. Since the causative pathogens in all patients were eradicated, no break points for required exposure could be found. The microbiological outcomes indicate that the current clinical dosage regimen provides sufficient drug exposure to eradicate the pathogens commonly involved in pediatric meningitis.
Family Reading Behavior and Early Literacy Skills in Preschool Children From Low-Income Backgrounds

This study investigated the family reading behavior of 233 preschool children from low-income backgrounds who were attending Head Start. Parents completed a survey of their family reading behavior, including Child Reading, Parent Reading Interest, and Parent–Child Reading Interaction, and provided demographic data on their educational level, parent and child age, and family size. Children's receptive vocabulary, story and print concepts, letter knowledge, and general emergent literacy skills were assessed in the fall of their preschool year. Analyses focused on the variation in family reading behavior, the relationship between different dimensions of family reading behavior, and the contribution of family reading behavior to early literacy skills. Results indicated that Parent–Child Reading Interaction and Child Reading Interest were significantly related to children's early literacy skills. In addition, multiple regression analyses indicated that Parent–Child Reading Interaction was a small yet significant predictor of children's receptive vocabulary, story and print concepts, and general emergent literacy skills, above and beyond the influence of demographic variables. Child Reading Interest was a significant, albeit small, predictor of letter knowledge above and beyond these demographic controls. Implications of these results for the early literacy education of children of low-income families are discussed.
Bezold-Jarisch reflex blunts arterial baroreflex via the shift of neural arc toward lower sympathetic nerve activity.

Although the Bezold-Jarisch (BJ) reflex is potentially evoked during acute myocardial ischemia or infarction, its effects on the static characteristics of the arterial baroreflex remain to be analyzed in terms of an equilibrium diagram between the neural and peripheral arcs. The neural arc represents the static input-output relationship between baroreceptor pressure input and efferent sympathetic nerve activity (SNA), whereas the peripheral arc represents that between SNA and arterial pressure (AP). In 8 anesthetized rabbits, we increased carotid sinus pressure stepwise from 40 to 160 mmHg in increments of 20 mmHg at one-minute intervals while measuring renal SNA and AP under control conditions and during the activation of the BJ reflex by intravenous administration of phenylbiguanide (PBG, 100 microg.kg(-1). min(-1)). The neural arc approximated a sigmoid curve whereas the peripheral arc approximated a straight line. PBG decreased AP at the operating point from -91.3 +/- 2.4 to -71.7 +/- 3.1 mmHg (P < 0.01), and attenuated the total loop gain at the operating point from -1.31 +/- 0.44 to -0.51 +/- 0.14 (P < 0.05). The equilibrium diagram indicated that PBG caused a parallel shift of the neural arc toward lower SNA such that the maximum SNA was reduced to approximately 60% of control. PBG decreased neural and peripheral arc gains at the operating point to approximately 43% and 77%, respectively. In conclusion, the BJ reflex blunts arterial baroreflex via the shift of the neural arc toward lower SNA.
Clustering algorithm on high-dimension data partitional mended attribute

In this paper, a clustering algorithm on high-dimension data partitional mended attribute is put foreword. First of all, through partition of the attribute value and discriminant degree of element, Conjunctive discriminant rules on training set are got. secondly, different discriminant rules on base of mended attribute are found. Experimental results show: the judgement rules got through the training set can better discriminate the test set. thereby, Experimental results verify the effectiveness of the proposed algorithm.
InP-nanocrystal monolayer deposition onto silicon-on-insulator structures

We demonstrate, for the first time, the deposition of an InP nanocrystal monolayer onto a processed silicon-on-insulator substrate containing nanophotonic devices. From the first results, propagation losses of 1.7 dB/mm were obtained for wires coated with InP nanocrystals compared to 0.26 dB/mm for the uncoated case.
Crosstalk between decidual NK and CD14+ myelomonocytic cells results in induction of Tregs and immunosuppression

Regulatory T cells (Tregs) are thought to play a major role in pregnancy by inhibiting the maternal immune system and preventing fetal rejection. In decidual tissues, NK cells (dNK) reside in close contact with particular myelomonocytic CD14+ (dCD14+) cells. Here we show that the interaction between dNK and dCD14+ cells results in induction of Tregs. The interaction is mediated by soluble factors as shown by transwell experiments, and the prominent role of IFN-γ is revealed by the effect of a neutralizing monoclonal antibody. Following interaction with dNK cells, dCD14+ cells express indoleamine 2,3-dioxygenase (IDO), which, in turn, induces Tregs. Notably, unlike peripheral blood NK (pNK) cells, dNK cells are resistant to inhibition by the IDO metabolite L-kynurenine. “Conditioned” dCD14+ cells also may induce Tregs through transforming growth factor-β (TGF-β) production or CTLA-4–mediated interactions, as indicated by the effect of specific neutralizing Abs. Remarkably, only the interaction between dNK and dCD14+ cells results in Treg induction, whereas other coculture combinations involving either NK or CD14+ cells isolated from peripheral blood are ineffective. Our study provides interesting clues to understanding how the crosstalk between decidual NK and CD14+ cells may initiate a process that leads to Treg induction and immunosuppression. Along this line, it is conceivable that an impaired function of these cells may result in pregnancy failure.
High Blood Glucose Concentration Is a Risk Factor for Mortality in Middle-Aged Nondiabetic Men: 20-year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study

OBJECTIVE To assess the association between high but nondiabetic blood glucose levels and the risk of death from all causes, coronary heart disease (CHD), cardiovascular disease, and neoplasms. RESEARCH DESIGN AND METHODS We studied the 20-year mortality of non-diabetic, working men, age 44–55 years, in three European cohorts known as the Whitehall Study (n = 10,025), the Paris Prospective Study (n = 6,629), and the Helsinki Policeman Study (n = 631). These men were identified by their 2-h glucose levels following an oral glucose tolerance test and by the absence of a prior diagnosis of diabetes. As the protocol for the oral glucose tolerance test and methods for measuring glucose differed between studies, mortality was analyzed according to the percentiles of the 2-h and fasting glucose distributions, using the Cox's proportional hazards model. RESULTS Men in the upper 20% of the 2-h glucose distributions and those in the upper 2.5% for fasting glucose had a significantly higher risk of all-cause mortality in comparison with men in the lower 80% of these distributions, with age-adjusted hazard ratios of 1.6 (95% CI 1.4–1.9) and 2.0 (1.6–2.6) for the upper 2.5%. For death from cardiovascular and CHD, men in the upper 2.5% of the 2-h and fasting glucose distributions were at higher risk, with age-adjusted hazard ratios for CHD of 1.8 (1.4–2.4) and 2.7 (1.7–4.4), respectively. CONCLUSIONS If early intervention aimed at lowering blood glucose concentrations can be shown to reduce mortality, it may be justified to lower the levels of both 2-h and fasting glucose, which define diabetes.
Isolation, Characterization, and Heterologous Expression of the Novel Lantibiotic Epicidin 280 and Analysis of Its Biosynthetic Gene Cluster

ABSTRACT Epicidin 280 is a novel type A lantibiotic produced byStaphylococcus epidermidis BN 280. During C18reverse-phase high-performance liquid chromatography two epicidin 280 peaks were obtained; the two compounds had molecular masses of 3,133 ± 1.5 and 3,136 ± 1.5 Da, comparable antibiotic activities, and identical amino acid compositions. Amino acid sequence analysis revealed that epicidin 280 exhibits 75% similarity to Pep5. The strains that produce epicidin 280 and Pep5 exhibit cross-immunity, indicating that the immunity peptides cross-function in antagonization of both lantibiotics. The complete epicidin 280 gene cluster was cloned and was found to comprise at least five open reading frames (eciI, eciA, eciP,eciB, and eciC, in that order). The proteins encoded by these open reading frames exhibit significant sequence similarity to the biosynthetic proteins of the Pep5 operon ofStaphylococcus epidermidis 5. A gene for an ABC transporter, which is present in the Pep5 gene cluster but is necessary only for high yields (G. Bierbaum, M. Reis, C. Szekat, and H.-G. Sahl, Appl. Environ. Microbiol. 60:4332–4338, 1994), was not detected. Instead, upstream of the immunity gene eciI we found an open reading frame, eciO, which could code for a novel lantibiotic modification enzyme involved in reduction of an N-terminally located oxopropionyl residue. Epicidin 280 produced by the heterologous host Staphylococcus carnosus TM 300 after introduction of eciIAPBC (i.e., no eciO was present) behaved homogeneously during reverse-phase chromatography.
Immunocytochemical distribution of corticotropin‐releasing hormone receptor type‐1 (CRF1)‐like immunoreactivity in the mouse brain: Light microscopy analysis using an antibody directed against the C‐terminus

Corticotropin‐releasing hormone (CRH) receptor type 1 (CRF1) is a member of the receptor family mediating the effects of CRH, a critical neuromediator of stress‐related endocrine, autonomic, and behavioral responses. The detailed organization and fine localization of CRF1‐like immunoreactivity (CRF1‐LI) containing neurons in the rodent have not been described, and is important to better define the functions of this receptor. Here we characterize in detail the neuroanatomical distribution of CRF1‐immunoreactive (CRF1‐ir) neurons in the mouse brain, using an antiserum directed against the C‐terminus of the receptor. We show that CRF1‐LI is abundantly yet selectively expressed, and its localization generally overlaps the target regions of CRH‐expressing projections and the established distribution of CRF1 mRNA, with several intriguing exceptions. The most intensely CRF1‐LI‐labeled neurons are found in discrete neuronal systems, i.e., hypothalamic nuclei (paraventricular, supraoptic, and arcuate), major cholinergic and monoaminergic cell groups, and specific sensory relay and association thalamic nuclei. Pyramidal neurons in neocortex and magnocellular cells in basal amygdaloid nucleus are also intensely CRF1‐ir. Finally, intense CRF1‐LI is evident in brainstem auditory associated nuclei and several cranial nerves nuclei, as well as in cerebellar Purkinje cells. In addition to their regional specificity, CRF1‐LI‐labeled neurons are characterized by discrete patterns of the intracellular distribution of the immunoreaction product. While generally membrane associated, CRF1‐LI may be classified as granular, punctate, or homogenous deposits, consistent with differential membrane localization. The selective distribution and morphological diversity of CRF1‐ir neurons suggest that CRF1 may mediate distinct functions in different regions of the mouse brain. J. Comp. Neurol. 420:305–323, 2000. © 2000 Wiley‐Liss, Inc.
Probing the subsurface karst features using time-frequency decomposition

AbstractThe high-resolution mapping of karst features is of great importance to hydrocarbon discovery and recovery in the resource exploration field. Currently, however, there are few effective methods specifically tailored for such a task. The 3D seismic data can reveal the existence of karsts to some extent, but a precise characterization cannot be obtained. I have developed an effective framework for accurately probing the subsurface karst features using a well-developed time-frequency decomposition algorithm. More specifically, I have introduced a frequency interval analysis approach for obtaining the best karsts detection result using an optimal frequency interval. A high-resolution time-frequency transform was preferred in the proposed framework to capture the inherent frequency components hidden behind the amplitude map. Although the single-frequency slice could not provide a reliable karst depiction result, the summation over the selected frequency interval could obtain a high-resolution and high-.
Le matérialisme beauvoirien et la critique du naturalisme dans le Deuxième sexe : Une rupture épistémologique inachevée

L'actualite du Deuxieme sexe se manifeste pleinement dans la polemique contre le naturalisme. La critique du naturalisme chez Beauvoir comporte un aspect philosophique : la primaute de l'existence s'impose contre le naturalisme essentialiste; un aspect epistemologique : la serie causale/ explicative se situe de maniere homogene du cote de la societe, de la civilisation, de la culture; enfin un aspect politique : l'idee qu'il n'y a pas de fatalite conforte l'espoir que l'on peut changer quelque chose. La rupture ainsi inauguree par Beauvoir prend la forme d'un renversement epistemologique et donc d'une mise en evidence de l'ideologie. Cependant la demarche antinaturaliste de Beauvoir rencontre ses limites, parfois sous la forme de contradictions, et surtout dans la recherche des origines. Les defauts naturalistes dont le Deuxieme sexe est entache ne sont pas imputables a Beauvoir seule : ils portent la marque du temps; un temps qui est encore le notre, cinquante ans apres car le naturalisme continue de contaminer la pensee sociologique, et, dans celle-ci, la pensee feministe. Si la rupture epistemologique est sans doute inachevee dans le Deuxieme sexe, elle s'acheve, ou plus exactement elle se poursuit dans la pensee et les ecrits de Beauvoir, ainsi que dans la pensee et les ecrits d'autres feministes. En effet Beauvoir n'a cesse d'evoluer et de tendre vers un materialisme de plus en plus radical.
Influence of speed and flux estimation by Luenberger observer on IM drive with DTC

The direct torque control (DTC) strategy is one of the most performance methods for induction machine (IM) drive torque control. The controlled stator magnetic flux and torque cannot be easily measured and therefore must be calculated using an IM mathematical model. This paper examines the impact of the replacement the original voltage IM model by Luenberger observer on the drive performance. As the original model requires only voltage and current, the observer is implemented in such a way that the same input variables can be used. The models are created and tests are carried out experimentally employing the dSPACE platform on induction motor of power 5.5 kW. The experimental results indicate better performance of the control strategy based on Luenberger observer.
Risk factors for emesis after therapeutic use of activated charcoal in acutely poisoned children.

OBJECTIVES Vomiting frequently complicates the administration of activated charcoal. The incidence of such vomiting is not defined precisely in the pediatric population. Little is known about the patient-, poison-, or procedure-specific factors that contribute to emesis of charcoal. This study aimed to estimate the incidence of vomiting subsequent to therapeutic administration of charcoal to poisoned children < or =18 years of age and to examine the relative contributions of several risk factors to the occurrence of vomiting. METHODS Data were collected on a prospective cohort of 275 consecutive children who were treated with activated charcoal for acute poisoning exposure. The study was set in the emergency department of an urban, tertiary-care children's hospital. Sorbitol content of the charcoal was alternately assigned. Potential risk factors for vomiting were recorded prospectively, and the occurrence of vomiting within 2 hours of charcoal administration was measured. RESULTS A total of 56 (20.4%) of 275 patients vomited. Median time to vomiting was 10 minutes. Previous vomiting (relative risk: 3.41; 95% CI: 1.48-7.85) and nasogastric tube administration (relative risk: 2.40; 95% CI: 1.13-5.09) were found to be the most significant independent risk factors for vomiting. The increased risk among children >12 years of age, compared with younger children, approached significance. Sorbitol content, large charcoal volumes, or fast administration rates did not increase vomiting risk significantly. CONCLUSIONS One of every 5 children who are given activated charcoal within our pediatric emergency department vomited. Children with previous vomiting or nasogastric tube administration were at highest risk, and these factors should be accounted for in future investigation of antiemetic strategies. Sorbitol content of charcoal was not a significant risk factor for emesis.
Serum osmolality and outcome in intensive care unit patients

Background: The aim of the present study was to compare 16 routine clinical and laboratory parameters, acute physiologic and chronic health evaluation (APACHE) and sequential organ failure assessment (SOFA) score for their value in predicting mortality during hospital stay in patients admitted to a general intensive care unit (ICU).
The effect of sulfhydryl reagents on ribosome activity.

Ribosomes from Escherichia coli were incubated with sulfhydryl reagents and then after removal of the excess reagent assayed for polyuridylic acid dependent polyphenylalanine synthesis in the absence of both sulfhydryl reagents and thiols. Incubation with N-ethylmaleimide, dithiobis-(2-nitrobenzoic acid) and p-chloromercuribenzoic acid resulted in loss of activity between 30 and 70% in different ribosome preparations. Similar inactivation was observed in the polylysine assay system and in polyuridylic acid directed leucine incorporation (miscoding). Inactivation by dithiobis-(2-nitrobenzoic acid) was reversed by incubating the ribosomes with a thiol. The extent of inactivation was independent of whether the ribosomes were treated with the sulfhydryl reagent in the associated (70 S) or dissociated (50 S + 30 S) form. The sedimentation coefficients of the treated ribosomes and of the subunits prepared from them were not altered. The treated ribosomes were in the associated (70 S) form under the conditions of polyphenylalanine synthesis. No inhibition of the binding of polyuridylie acid was found. Inactivation occurred when the molar ratio of sulfhydryl reagent to 70 S ribosome was only 2 or 3, although the calculated half cystine content of the 70 S ribosome is 45 residues. The 30 S ribosome was the principle site of inhibition. The results indicate that at least some ribosomal half cystine is present as cysteine and that ribosomal SH groups, as well as supernatant transfer factor SH groups, are important in protein synthesis.
CD133 expression is associated with poor outcome in neuroblastoma via chemoresistance mediated by the AKT pathway

Sartelet H, Imbriglio T, Nyalendo C, Haddad E, Annabi B, Duval M, Fetni R, Victor K, Alexendrov L, Sinnett D, Fabre M & Vassal G (2012) Histopathology 60, 1144–1155
Circuitos diferenciales de microondas con rechazo del modo común basados en conceptos de metamateriales y en resonadores semidiscretos

El uso de dispositivos que operen con senales diferenciales y simultaneamente supriman el modo comun cada vez atrae mas la atencion de los ingenieros de microondas. El contenido de esta tesis esta enfocado en el estudio y diseno de circuitos balanceados de microondas utilizando tecnicas avanzadas de diseno y conceptos derivados de los metamateriales asi como el uso de resonadores semidiscretos. Mediante estos conceptos avanzados se han disenado componentes de doble banda (dual) y filtros diferenciales de microondas con buen comportamiento y dimensiones reducidas. Para sintetizar estructuras diferenciales con supresion del modo comun, se ha utilizado lineas de transmision artificiales basadas en componentes semidiscretos y mediante resonadores concentrados como pueden ser el OSRR y el OCSRR. Mediante el uso de dichas particulas se han obtenido filtros diferenciales con elevados anchos de banda, asi como inversores de impedancia duales diferenciales y divisores de potencia balanceados. Todas las implementaciones que se encuentran en este trabajo proporcionan la capacidad para rechazar el modo comun de manera inherente (sin la necesidad de anadir etapas adicionales al diseno). Primeramente se han disenado filtros balanceados mediante resonadores en salto de impedancia en configuracion diferencial e inversores de admitancia. Posteriormente se han utilizado lineas con comportamiento compuesto zurdo/diestro (CRLH) con topologia diferencial para disenar inversores de impedancia duales y su aplicacion mas directa como son los divisores de potencia diferenciales basados en la union en Y. A continuacion se ha explorado la opcion de ensanchar los anchos de banda de operacion de filtros diferenciales de microondas mediante resonadores concentrados y semidiscretos. Todos los conceptos explorados en esta tesis han sido validados mediante prototipos que han demostrado un buen ajuste entre simulacion circuital, simulacion electromagnetica y medida. Mediante el concepto de cristal electromagnetico (o Electromagnetic BandGap –EBG-), se han disenado filtros diferenciales capaces de cubrir el espectro UWB y con un buen comportamiento fuera de la banda de interes, asi como la supresion del modo comun en la banda filtrante. Tambien se ha explorado la opcion de disenar reflectores en lineas diferenciales (microstrip), para la cancelacion del modo comun mediante la teoria derivada del acoplo de modos. Los resultados obtenidos despues de caracterizar las estructuras, validan los circuitos propuestos. De manera adicional, se ha realizado un estudio teorico sobre las redes en celosia y como su topologia puede proporcionar caracteristicas diferentes a las obtenidas mediante lineas artificiales CRLH basadas en un modelo en T o en ? Estas diferencias se hacen patentes en su impedancia caracteristica ya que, bajo ciertas limitaciones, esta no depende de la frecuencia. Este fenomeno ha sido aprovechado para obtener divisores de potencia operativos en dos bandas mostrando un ensanchamiento del ancho de banda operativo del dispositivo.
Prospective Study of the Psychiatric Disorders of Childbirth

Summary A representative sample of 105 women were assessed by Goldberg's Standardised Psychiatric Interview (SPI) on two occasions during pregnancy and twice more in the puerperium. Total SPI scores increased significantly after childbirth. Thirteen out of the sample had a severe postnatal depression and a further 17 women had milder depression, which in 15 lasted at least four weeks. Marked deterioration of their marital relationships was reported by the depressed women but no other social or obstetric characteristics of postnatal depression were found. Women with severe postnatal blues were particularly at risk of developing persistent depressive symptoms subsequently. The only two women referred to a psychiatrist had personality disorders rather than depressive illnesses.