Miracle-dz/UniFAR-FTUs huggingface dataset:
Preliminary Results of Subconjunctival Bevacizumab in Primary Pterygium Excision

Purpose: To evaluate the efficacy of subconjunctival bevacizumab as an adjunctive therapy for primary pterygium surgery. Material and Methods: This randomized prospective clinical study was conducted on 30 eyes of 30 patients. After pterygium excision and accomplishing a rotational conjunctival flap, 15 patients (case group) received 1.25 mg (0.1 ml) bevacizumab, and 15 other patients (control group) received 0.1 ml balanced salt solution subconjunctivally. The main outcome measures were recurrence of pterygia, horizontal length of the corneal epithelial defect, conjunctival erythema, lacrimation and photophobia during the first postoperative week. Results: There were no statistically significant differences regarding age, sex or recurrence risk factors between the two groups (p > 0.05). The pterygia resolved in 13 (86.6%) of 15 eyes in both groups, with a recurrence rate of 13.4% during a mean follow-up period of 8 ± 1.4 months in the case group and 7.4 ± 1.5 months in the control group (p = 0.2). There were no statistically significant differences regarding reduction in refractive astigmatism, improvement in visual acuity, corneal epithelial defects, conjunctival erythema, lacrimation or photophobia between the case and control groups (p > 0.05). Conclusions: A single intraoperative subconjunctival bevacizumab injection had no effect on recurrence rate or early postoperative conjunctival erythema, lacrimation, photophobia or healing of corneal epithelial defects following pterygium excision.
Differential effect of muscle vibration on intracortical inhibitory circuits in humans

Low amplitude muscle vibration (0.5 ms; 80 Hz; duration 1.5 s) was applied in turn to each of three different intrinsic hand muscles (first dorsal interosseus, FDI; abductor pollicis brevis, APB; and abductor digiti minimi, ADM) in order to test its effect on the EMG responses evoked by transcranial magnetic stimulation (TMS). Recordings were also taken from flexor and extensor carpi radialis (FCR and ECR, respectively). We evaluated the amplitude of motor evoked potentials (MEPs) produced by a single TMS pulse, short interval intracortical inhibition and facilitation (SICI and ICF) and long interval intracortical inhibition (LICI). TMS pulses were applied 1 s after the start of vibration with subjects relaxed throughout. Vibration increased the amplitude of MEPs evoked in the vibrated muscle (162 ± 6 % of MEP with no vibration; mean ±s.e.m.), but suppressed MEPs in the two non‐vibrated hand muscles (72 ± 9 %). Compared with no vibration (test response reduced to 51 ± 5 % of control), there was less SICI in the vibrated muscle (test response reduced to 92 ± 28 % of control) and more in the non‐vibrated hand muscles (test response reduced to 27 ± 5 % of control). The opposite occurred for LICI: compared with the no vibration condition (test response reduced to 33 ± 6 % control), there was more LICI in the vibrated muscle (test response reduced to 17 ± 3 % control) than in the non‐vibrated hand muscles (test response reduced to 80 ± 11 % control) even when the intensity of the test stimulus was adjusted to compensate for the changes in baseline MEP. There was no effect on ICF. Cutaneous stimulation of the index finger (80 Hz, 1.5 s duration, twice sensory threshold) had no consistent differential effect on any of the parameters. We conclude that vibratory input from muscle can differentially modulate excitability in motor cortical circuits.
Interobserver reliability of teledermatology across all Fitzpatrick skin types

Introduction Demand for dermatologic services in safety net hospitals, which disproportionately serve patients with darker coloured skin, is growing. Teledermatology has the potential to increase access and improve outcomes, but studies have yet to demonstrate the reliability of teledermatology for all Fitzpatrick skin types. Methods We assessed the reliability of teledermatologists’ diagnoses and management recommendations for store-and-forward teledermatology in patients with lightly pigmented (Fitzpatrick skin types I–III) versus darkly pigmented (Fitzpatrick skin types IV–VI) skin, when compared to in-person diagnosis and management decisions. This prospective study enrolled 232 adult patients, presenting with new, visible skin complaints in a Los Angeles county dermatology clinic. Forty-seven percent of patients were Fitzpatrick skin types I–III, and 53% were Fitzpatrick skin types IV–VI. Results Percent concordance for the identical primary diagnosis was 53.2% in lighter (Fitzpatrick I–III) skin types and 56.0% in darker (Fitzpatrick IV–VI) skin types. There was no statistically significant difference in concordance rates between lighter and darker skin types for primary diagnosis. Concordance rates for diagnostic testing, clinic-based therapy, and treatments were similar in both groups of Fitzpatrick skin types. Discussion These results suggest that teledermatology is reliable for the diagnosis and management of patients with all Fitzpatrick skin types.
[Prevalence of psychiatric disorders in primary and middle school students in Hunan Province].

OBJECTIVE To investigate the prevalence of psychiatric disorders in a representative sample of primary and middle school students in Hunan Province. METHODS A total of 9 495 children aged 5-17 years from Hunan urban and rural schools were enrolled by a cluster sampling and a two-phase design. The students' psychiatric status was assessed using the Investigation Screening Inventory for Child Mental Disorder and a semi-structured interview designed based on the DSM-IV criteria. RESULTS The overall prevalence of psychiatric disorders was 16.22%. Attention-deficit and disruptive behavior disorders were the commonest in the diagnostic categories of psychiatric disorders (10.69%). Regarding specific disorders, the most prevalent was attention-deficit/hyperactivity disorder (5.95%). Psychiatric disorders were more prevalent in boys than in girls (20.49% vs 11.16%; p<0.01). The prevalence of attention-deficit and disruptive behavior disorders in boys was higher than in girls (14.76% vs 5.87%; p<0.01). The prevalence of psychiatric disorders in middle school students (12-17 years) was significantly higher than in primary students (5-11 years) (18.38% vs 14.64%; p<0.01). There were no significant differences in the prevalence of psychiatric disorders between urban and rural students. CONCLUSIONS Psychiatric disorders are common among primary and middle school students in Hunan Province. The prevalence of this disorder in boys is higher than in girls. The middle school students have higher prevalence than primary students.
Multi-parameter observation of environmental asbestos pollution at the Institut de Physique du Globe de Paris (Jussieu Campus, France).

An original multi-parameter system has been used to study the nature of dust in the ambient air, particularly the total fibers and asbestos fibers, in eight areas of the Institut de Physique de Globe de Paris (France). These analyses provide a detailed case study of environmental pollution by asbestos fibers at low levels. The levels of total fibers with a length greater than 3 microns, measured with a real time fiber analyser monitor (FAM), give a baseline of 2.5 fibers per l. , throughout the duration of sampling. The same levels, calculated during periods of effective presence of staff, are smaller than 10 fb per l. During these periods, the instantaneous value can show high peaks, reaching a maximum of 60 fb per l. , but more often of about 5 to 10 fb per l. A direct cause and effect relationship exists between fiber concentrations and the presence of people, and indirectly with the variation of the other environmental parameters (temperature, humidity, air velocity). The baseline concentration of asbestos fibers, determined by analytical transmission electron microscopy (ATEM), is about 10(-1) fb per l. , with a mean value during the presence of people always less than 1.5 fb per l. The low levels of asbestos fibers do not allow us to establish a precise correlation between the concentration of total fibers and the asbestos concentration, but a rough estimate suggests that asbestos could represent 10-20% of the airborne fibers monitored with the FAM. The statistical study of fiber sizes shows that 70 and 55% of analyzed chrysotile and amosite fibers respectively are smaller than 5 microns. These numbers are 40 and 35% for fibers smaller than 3 microns, which are undetected by the FAM. Amosite, which characterizes most of the asbestos-containing materials (ACM) in the analyzed areas, is detected in the ambient air in quantities ten times less important than chrysotile. The low asbestos levels and the difference between the nature of building asbestos and airborne fibers, show that the mean measured asbestos contents in the ambient air represent the geochemical background of chrysotile asbestos fibers in the Parisian air.
In Vivo Calcium Signaling during Synaptic Refinement at the Drosophila Neuromuscular Junction

Neural activity plays a key role in pruning aberrant synapses in various neural systems, including the mammalian cortex, where low-frequency (0.01 Hz) calcium oscillations refine topographic maps. However, the activity-dependent molecular mechanisms remain incompletely understood. Activity-dependent pruning also occurs at embryonic Drosophila neuromuscular junctions (NMJs), where low-frequency Ca2+ oscillations are required for synaptic refinement and the response to the muscle-derived chemorepellant Sema2a. We examined embryonic growth cone filopodia in vivo to directly observe their exploration and to analyze the episodic Ca2+ oscillations involved in refinement. Motoneuron filopodia repeatedly contacted off-target muscle fibers over several hours during late embryogenesis, with episodic Ca2+ signals present in both motile filopodia as well as in later-stabilized synaptic boutons. The Ca2+ transients matured over several hours into regular low-frequency (0.03 Hz) oscillations. In vivo imaging of intact embryos of both sexes revealed that the formation of ectopic filopodia is increased in Sema2a heterozygotes. We provide genetic evidence suggesting a complex presynaptic Ca2+-dependent signaling network underlying refinement that involves the phosphatases calcineurin and protein phosphatase-1, as well the serine/threonine kinases CaMKII and PKA. Significantly, this network influenced the neuron's response to the muscle's Sema2a chemorepellant, critical for the removal of off-target contacts. SIGNIFICANCE STATEMENT To address the question of how synaptic connectivity is established during development, we examined the behavior of growth cone filopodia during the exploration of both correct and off-target muscle fibers in Drosophila embryos. We demonstrate that filopodia repeatedly contact off-target muscles over several hours, until they ultimately retract. We show that intracellular signals are observed in motile and stabilized “ectopic” contacts. Several genetic experiments provide insight in the molecular pathway underlying network refinement, which includes oscillatory calcium signals via voltage-gated calcium channels as a key component. Calcium orchestrates the activity of several kinases and phosphatases, which interact in a coordinated fashion to regulate chemorepulsion exerted by the muscle.
A cytoarchitectonic atlas of the medial geniculate body of the opossum, Didelphys virginiana, with a comment on the posterior intralaminar nuclei of the thalamus

The organization of the medial geniculate body and adjacent posterior thalamus of the Virginia opossum was studied in Nissl‐, Golgi‐, reduced silver, and myelin‐stained preparations. Our chief goals were to define the cytoarchitectonic subdivisions and boundaries in Nissl preparations and to reconcile these with those observed with the Golgi method and in experimental material, to present these results in an atlas of Nissl‐stained sections, and to compare the chief nuclear groups in the opossum and the cat medial geniculate body.
A Novel Semiautomatic Technique for Volumetric Assessment of the Alveolar Bone Defect Using Cone Beam Computed Tomography

Objective The aims of this study were (1) to determine the three-dimensional anatomical boundaries of the alveolar bone defect in cleft lip and palate (CLP) patients, (2) to precisely translate these anatomical boundaries into reliable cephalometric landmarks and planes that can be used for cone beam computed tomography (CBCT) analysis, (3) to standardize image acquisition and reconstruction parameters, and (4) to test the reproducibility of the proposed protocol for measuring the predefined alveolar bone defect, using a third-party software. Methods The alveolar bone defect volume of 10 randomly selected patients with unilateral CLP (UCLP) aged 8 years and 6 months to 11 years and 2 months was evaluated on preoperative and 1-year postoperative CBCT scans using a semiautomatic, standardized protocol. The alveolar bone graft outcome was calculated as a percentage of the bone fill using the formula (VOLpre – VOLpost)/VOLpre) × 100. Intra- and interobserver reliability was assessed. Results Intra- and interobserver reproducibility was excellent for volumes and bone fill as no statistically significant difference (P < .001) was seen between the different sets of measurements, and Pearson correlation coefficients were large (intraobserver: r > .9849, interobserver: r > .8784). The Bland-Altman plots indicated that the differences between the plots were not patterned. Conclusions Volume determination using CBCT, third-party medical image processing software, and the presently defined image acquisition and reconstruction parameters, including anatomical boundaries, is a reproducible and practical method for assessing the volumetric outcome of secondary alveolar bone grafting in patients with UCLP.
Separate and Combined Influences of Dehydration and Hyperthermia on Cardiovascular Responses to Exercise

During endurance exercise in the heat athletes lose 1-21/h of fluid due to thermoregulatory sweating. The ensuing dehydration is accompanied by higher and faster increases in core temperature, which per se can cause fatigue. The main cardiovascular consequences of combined dehydration and hyperthermia [1 degree C higher core temperature and 3-4 kg (4%) body weight loss] are the significant reductions in cardiac output (3 l/min), muscle blood flow, skin blood flow and blood pressure. Separately, however, hyperthermia (i.e., 39.3 C) and dehydration do not significantly reduce cardiac output or blood pressure. In conclusion, the superimposition of dehydration on hyperthermia during exercise in the heat causes greater alterations in cardiovascular function that make the dehydrated athlete much less able to cope with hyperthermia.
Different classes of volume transmission signals exist in the central nervous system, and are affected by metabolic signals, temperature gradients, and pressure waves

VOLUME transmission (VT) is the mode of intercellular communication involving the diffusion of transmitters, via extracellular fluid (ECF) pathways, from nerve cells selectively capable of producing the signal (signal source) to nerve, and glial cells selectively capable of recognizing it (signal target). The proposal is now put forward that at least two classes of VT signals can be distinguished: (a) the private-code signals, exemplified by neurotransmitters, which are released by a limited group of nerve cells, and recognized, via high affinity G-protein coupled receptors or by cytosolic enzymes such as guanylate cyclase in the case of nitric oxide, by a specific group of cells;, and (b) the accessible-code signals, such as the electrical signals that are released by all neuronal cells, and decoded by almost every CNS cell. In the present paper, it will be underlined that carbon dioxide, hydrogen ions, temperature gradients, and pressure waves may be regulators of wiring transmission, and VT.
Computed acceleration control for the vibration suppression of flexible robotic manipulators

Proposes a control scheme, called computed acceleration control, for the control of spatial flexible robotic manipulators. In the scheme the joint accelerations are computed from the equations of link elastic motion (vibration) after regarding the accelerations as the control inputs to the equations. The equations of overall motion (joint motion) is then used to compute the control commands to the joint motors. It is shown that this scheme gives a theoretical solution to the problem of designing a variable gain controller for the vibration suppression of the spatial flexible manipulators. The theory is followed by an example of a three degrees-of-freedom spatial manipulator and a preliminary experiment using a planar manipulator driven by velocity servos. <<ETX>>
Social inequality and educational decisions over the life course: An educational sociology perspective

Der vorliegende Beitrag setzt sich das Ziel, auf der Grundlage soziologischer Theorien und ausgewahlter Forschungsergebnisse den Einfluss der Familie auf die Bildungschancen der Kinder aus einer Lebensverlaufsperspektive auf­zuzeigen. Im Vordergrund stehen dabei die sogenannten primaren, sekundaren und tertiaren Effekte der sozialen Herkunft. Die Ergebnisse zeigen, dass in Deutschland die soziale Herkunft noch immer zu den wichtigsten Faktoren gehort, die die Bildungschancen von Schulern beeinflussen. Dabei beeinflusst die Herkunftsfamilie die Bildungskarriere kumulativ. Auch uber die Kohorten hinweg ist die Wirkung der sozialen Herkunft auf die Bildungschancen relativ stabil.
Familial and socioregional environmental effects on abstinence from alcohol at age sixteen.

OBJECTIVE This study identifies, in genetically informative data, familial and socioregional environmental influences on abstinence from alcohol at age 16. METHOD Data are from FinnTwin 16, a population-based study of five consecutive birth cohorts of Finnish twins (N = 5,747 twin individuals), yielding 2,711 pairs of known zygosity. Measures of alcohol use, embedded into a health-habits questionnaire, were taken from earlier epidemiological research with nontwin Finnish adolescents. The questionnaire was administered sequentially to all twins as they reached age 16. Separate questionnaires, including measures of alcohol use and screening questions for alcohol problems, were received from 5,243 of the twins' parents. RESULTS Abstinence from alcohol to age 16 exhibits very significant familial aggregation, largely due to nongenetic influences. Abstinence rates are influenced by socioregional variation, sibling interaction effects and parental drinking patterns. Sibling and parental influences are greater in some regional environments than in others: the relative likelihood that a twin abstains, given that the co-twin does, or that both parents do, is shown to be modulated by socioregional variation. CONCLUSION Environmental contexts affect the likelihood of maintaining abstinence from alcohol to midadolescence, and socioregional variation modulates influences of siblings and parents. The results illustrate how genetically informative data can inform prevention research by identifying target variables for intervention efforts.
Heart Rate Variability Reflects Training Load and Psychophysiological Status in Young Elite Gymnasts

Abstract Sartor, F, Vailati, E, Valsecchi, V, Vailati, F, La Torre, A. Heart rate variability reflects training load and psychophysiological status in young elite gymnasts. J Strength Cond Res 27(10): 2782–2790, 2013—In gymnastics, monitoring of the training load and assessment of the psychophysiological status of elite athletes is important for training planning and to avoid overtraining, consequently reducing the risk of injures. The aim of this study was to examine whether heart rate variability (HRV) is a valuable tool to determine training load and psychophysiological status in young elite gymnasts. Six young male elite gymnasts took part in a 10-week observational study. During this period, beat-to-beat heart rate intervals were measured every training day in weeks 1, 3, 5, 7, and 9. Balance, agility, upper limb maximal strength, lower limb explosive, and elastic power were monitored during weeks 2, 4, 6, 8, and 10. Training load of each training session of all 10 weeks was assessed by session rating of perceived exertion (RPE) and psychophysiological status by Foster’s index. Morning supine HRV (HF% and LF%/HF%) correlated with the training load of the previous day (r = 0.232, r = −0.279, p < 0.05 ). Morning supine to sitting HRV difference (mean R wave to R wave interval (RR), mean heart rate, HF%, SD1) correlated with session RPE of the previous day (r = −0.320, r = 0.301, p < 0.01; r = 0.265, r = −0.270, p < 0.05) but not with Foster’s index. Training day/reference day HRV difference (mean RR, SD1) showed the best correlations with session RPE of the previous day (r = −0.384, r = −0.332, p < 0.01) and Foster’s index (r = −0.227, r = −0.260, p < 0.05). In conclusion, HRV, and in particular training day/reference day mean RR difference or SD1 difference, could be useful in monitoring training load and psychophysiological status in young male elite gymnasts.
Analyse scientométrique de la crise économique : Courants de pensée, auteurs influents et thématiques

En s'appuyant sur les techniques de cartographie, en se basant sur l'analyse textuelle et l'analyse des reseaux de citations nous avons analyse le developpement de la thematique de la crise economique. L'objectif est de montrer dans un premier temps les courants de pensee et les auteurs influents. Dans un second temps comprendre son evolution a travers le temps. Pour ce faire, nous avons extrait de l'interface du WOS en ligne l'ensemble des publications contenant le mot « crisis » dans les categories disciplinaires « economics » et « business & finance ». Notre requete renvoie plus de 24000 publications. Nos resultats nous ont permis de montrer les differents courants de pensee dominant l'analyse de la crise economique ainsi que les auteurs les plus influents. L'analyse textuelle des termes presents dans les titres, resume et mots-cles montre des changements majeurs dans la facon dont les economistes traitent le sujet. Desormais, une bonne partie des publications traitant la thematique de la crise economique cherche non pas a traiter les consequences ou a proposer des solutions, mais plutot prevoir l'avenement des crises a travers l'analyse des differents risques qui conduiraient a une crise. Nous avons montre egalement que cette thematique est tres fortement dominee par la finance tant au niveau microeconomique que macroeconomique.
Symbiosis-Promoting and Deleterious Effects of NopT, a Novel Type 3 Effector of Rhizobium sp. Strain NGR234

ABSTRACT Establishment of symbiosis between certain host plants and nitrogen-fixing bacteria (“rhizobia”) depends on type 3 effector proteins secreted via the bacterial type 3 secretion system (T3SS). Here, we report that the open reading frame y4zC of strain NGR234 encodes a novel rhizobial type 3 effector, termed NopT (for nodulation outer protein T). Analysis of secreted proteins from NGR234 and T3SS mutants revealed that NopT is secreted via the T3SS. NopT possessed autoproteolytic activity when expressed in Escherichia coli or human HEK 293T cells. The processed NopT exposed a glycine (G50) to the N terminus, which is predicted to be myristoylated in eukaryotic cells. NopT with a point mutation at position C93, H205, or D220 (catalytic triad) showed strongly reduced autoproteolytic activity, indicating that NopT is a functional protease of the YopT-AvrPphB effector family. When transiently expressed in tobacco plants, proteolytically active NopT elicited a rapid hypersensitive reaction. Arabidopsis plants transformed with nopT showed chlorotic and necrotic symptoms, indicating a cytotoxic effect. Inoculation experiments with mutant derivatives of NGR234 indicated that NopT affected nodulation either positively (Phaseolus vulgaris cv. Yudou No. 1; Tephrosia vogelii) or negatively (Crotalaria juncea). We suggest that NopT-related polymorphism may be involved in evolutionary adaptation of NGR234 to particular host legumes.