Miracle-dz/UniFAR-FTUs huggingface dataset:
Regional anesthesia techniques for ambulatory orthopedic surgery

Purpose of review The purpose of this review is to present advances in the use of regional anesthetic techniques in ambulatory orthopedic surgery. New findings regarding the use of both neuraxial anesthesia and peripheral nerve block are discussed. Recent findings Neuraxial anesthesia: The use of short-acting local anesthetic agents such as mepivacaine, 2-chloroprocaine, and articaine permits rapid onset intrathecal anesthesia with early recovery profiles. Advantages and limitations of these agents are discussed. Peripheral nerve block: Peripheral nerve blocks in limb surgery have the potential to transform this patient cohort into a truly ambulatory, self-caring group. Recent trends and evidence regarding the benefits of regional anesthesia techniques are presented. Continuous perineural catheters permit extension of improved perioperative analgesia into the ambulatory home setting. The role and reported safety of continuous catheters are discussed. Summary In summary, shorter acting, neuraxial, local anesthetic agents, specific to the expected duration of surgery, may provide superior recovery profiles in the ambulatory setting. A trend towards more peripheral and selective nerve blocks exists. The infrapatellar block is a promising technique to provide analgesia following knee arthroscopy. Improved analgesia seen in the perioperative period can be safely and effectively extended to the postoperative period with the use of perineural catheters.
Single-End Spectral Resolved Measurement of Polarization Mode Dispersion in Optical Fibers

An improved single-end backreflection technique is proposed to perform the spectral resolved measurement of polarization mode dispersion (PMD) in optical fibers. This technique is based on the PMD dynamical equation, which is realized by measuring the reflected polarization state evolution in both frequency and time domains. An experimental setup, employing continuous-wave and far-end Fresnel reflection, is constructed. The agreement between the results of single-end and forward measurements is very good.
Impact of Foreign Direct Investment (FDI) Inflows on Equilibrium Real Exchange Rate of Pakistan

This study aims to analyze the impact of foreign exchange inflows on equilibrium real exchange rate of Pakistan for the period 1993 M7 to 2009 M3 through behavioral equilibrium real exchange rate (BEER) approach. The BEER approach uses econometric technique of cointegration to establish a behavioral link between the real exchange rate and relevant macroeconomic fundamentals. The study shall conclude that massive foreign direct investment inflows and workers ‘remittances have significantly appreciated equilibrium real exchange rate of Pakistan. The purpose of this paper is to investigate the impact of foreign exchange inflows in Pakistan in the form of FDI and workers’ remittances on equilibrium real exchange rate of Pakistan.
Age and sex differences in ranges of motion and motion patterns

This study investigated the effects of age and sex on joint ranges of motion (ROMs) and motion patterns. Forty participants performed 18 motions using eight body segments at self-selected speeds. Older subjects showed smaller ROMs than younger subjects for 11 motions; the greatest difference in ROM was 44.9% for eversion/inversion of the foot. Older subjects also required more time than younger subjects to approach the peak angular velocity for six motions. In contrast, sex significantly affected ROMs but not motion patterns. Male subjects exhibited smaller ROMs than female subjects for four motions; the greatest sex-dependent difference in ROM was 29.7% for ulnar/radial deviation of the hand. The age and sex effects depended on the specific segments used and motions performed, possibly because of differences in anatomical structures and frequencies of use of the joints in habitual physical activities between the groups.
Electrosprayed bovine serum albumin-loaded tripolyphosphate cross-linked chitosan capsules: Synthesis and characterization

Bovine serum albumin (BSA)-loaded tripolyphosphate (TPP) cross-linked chitosan capsules were prepared using an electrospraying technique, in which a sufficiently strong electric field was applied to overcome the surface tension of a droplet. A comprehensive investigation was conducted on the effects of concentrations of initial chitosan and TPP solutions, flow rate and BSA/chitosan weight ratio on the physical properties of the mixtures; the morphology, size and yield of the capsules; BSA encapsulation efficiency (EE) and loading capacity (LC); and in vitro release. A high voltage was required to obtain a continuous and stable spray for the mixtures with a high viscosity at high chitosan concentration. The capsules were spherical in shape. Capsule size increased with increasing flow rate, but did not change significantly (p < 0.05) with increases in concentrations of chitosan and TPP. Increasing concentrations of chitosan and TPP solutions increased the yields, while yields decreased with increases in the flow rate. EE and LC increased with increasing chitosan concentration, BSA/chitosan weight ratio and TPP concentration and decreased with increasing flow rate. High EE enhanced the BSA release rate, while a high degree of cross-linking slowed its release.
Association of Nutritional Risk and Depressive Symptoms with Physical Performance in the Elderly: The Quebec Longitudinal Study of Nutrition as a Determinant of Successful Aging (NuAge)

Objective: Depressive symptoms and poor nutritional status have been associated with declines in physical capacity. However, it is not clear whether they exert independent effects and potential for interaction among these two variables has not been studied. The purpose of this report is to clarify the relationships between depressive symptoms and nutritional risk and physical capacity. Methods: Baseline data from community-living and well functioning men and women (n = 1,755) participating in the longitudinal study NuAge (Quebec, Canada), aged 67–84 years were used for this study. Physical performance (PP) was defined as the summary score of 4 tests of physical capacity [Standing Balance, Walking Speed, Chair Stands, and Timed “Up &Go”]. Depressive symptoms were measured with the Geriatric Depression Scale (GDS), and nutritional risk by the Elderly Nutrition Screening (ENS©) tool. Results: Prevalence of mild depression (GDS score ≥11 and ≤ 20) was 12% in women and 7.6% in men (p = 0.002). Higher PP was observed among subjects without nutritional risk or mild depression (mean score: 10.45 ± 3.45) as compared to those with both risk factors (8.66 ± 3.59; p < 0.001). In multiple linear regression analysis, both depressive symptoms and nutritional risk scores were independently associated with PP score after adjustment for age, sex, educational level, income, burden of disease, body mass index and physical activity. There was no interaction of nutritional risk and depressive symptoms in relation to PP. The overall adjusted multiple regression model explained 34% of the observed variance in physical performance score. Conclusions: Nutritional risk and depressive symptoms are both potentially modifiable independent correlates of PP but there is no synergistic effect of the two risk factors.
Amelioration of Ethanol-Induced Hepatitis by Magnesium Isoglycyrrhizinate through Inhibition of Neutrophil Cell Infiltration and Oxidative Damage

Alcoholic liver disease (ALD) is a leading cause of liver-related morbidity and mortality worldwide. There is no effective treatment to prevent the disease progression. Magnesium isoglycyrrhizinate (MgIG) showed potent anti-inflammatory, antioxidant, and hepatoprotective activities and was used for treating liver diseases in Asia. In this study, we examined whether MgIG could protect mice against alcohol-induced liver injury. The newly developed chronic plus binge ethanol feeding model was used to study the role of MgIG in ALD. Serum liver enzyme levels, H&E staining, immunohistochemical staining, flow cytometric analysis, and real-time PCR were used to evaluate the liver injury and inflammation. We showed that MgIG markedly ameliorated chronic plus binge ethanol feeding liver injury, as shown by decreased serum alanine transaminase and aspartate aminotransferase levels and reduced neutrophil infiltration. The reason may be attributed to the reduced expression of proinflammatory cytokines and chemokines with the treatment of MgIG. The hepatoprotective effect of MgIG was associated with suppression of neutrophil ROS production as well as hepatocellular oxidative stress. MgIG may play a critical role in protecting against chronic plus binge ethanol feeding-induced liver injury by regulating neutrophil activity and hepatic oxidative stress.
M‐cells are damaged and increased in number in inflamed human ileal mucosa

Ileocolonoscopy and biopsies of patients with spondylarthropathy reveal gut inflammation in 62% of cases. In order to better understand the pathogenetic mechanisms of spondylarthropathy‐related gut inflammation, the follicle‐associated epithelium was examined. Biopsies from nine controls and 18 patients with spondylarthropathy were studied by electronmicroscopy. Membranous (M) cells were investigated in normal and inflamed ileum. In normal mucosa, M‐cells were scarce whereas in inflamed mucosa their number was increased (up to 24% of follicle‐associated epithelial cells). They showed a thin rim of cytoplasm covering groups of lymphocytes. In chronic ileitis, necrotic M‐cells, rupture of M‐cells and lymphocytes entering the gut lumen were observed. The bursting of M‐cells at the top of the lymphoid follicles leads to interruption of the gut epithelial lining and gives the luminal content access to the lymphoid tissue. This pathogenetic mechanism may cause aphthoid ulcers.
Use of mammary gland and colostral characteristics for prediction of colostral IgG1 concentration and intramammary infection in Holstein cows.

OBJECTIVE To determine whether mammary gland or colostral characteristics at calving could be used to predict colostral immunoglobulin G1 (IgG1) concentration or intramammary infection (IMI) and whether leakage of colostrum affects IgG1 concentration. DESIGN Prospective study. ANIMALS 113 multiparous Holstein cows. PROCEDURE Cows were examined within 3 hours of calving, and mammary gland and colostral characteristics, colostral volume, somatic cell count, and concentrations of IgG1, fat, and protein were determined. Bacteriologic culture of mammary secretions was performed approximately 14 and 7 days before calving and at calving. Associations of gland and colostral characteristics with colostral IgG1 concentration, colostral volume, and IMI were examined. RESULTS Thick or thin colostrum had higher IgG1 concentration than colostrum of intermediate viscosity. Colostrum from mammary glands that were firm had low IgG1 concentration. Colostral IgG1 concentration was weakly correlated with volume. Intramammary infection was likely to be detected if colostrum contained clots or blood or if the California Mastitis Test (CMT) score was > or = 2. Somatic cell count was higher for glands with IMI than for uninfected glands, and CMT score was correlated with cell count. CLINICAL IMPLICATIONS Mammary gland and colostral characteristics were of little value in predicting IgG1 concentration. Our findings do not support recommendations that first milking colostrum that is thin (watery) or that is from cows producing large volumes not be fed to dairy calves. Colostral characteristics, particularly CMT score, were of value for predicting IMI.
Microbial Taxa Distribution Is Associated with Ecological Trophic Cascades along an Elevation Gradient

The elevational pattern of soil microbial diversity along mountain slopes has received considerable interest over the last decade. An increasing amount of taxonomic data on soil microbial community composition along elevation gradients have been collected, however the trophic patterns and environmental drivers of elevational changes remain largely unclear. Here, we examined the distribution patterns of major soil bacterial and fungal taxa along the northern slope of Changbai Mountain, Northeast China, at five typical vegetation types located between 740 and 2,691 m above sea level. Elevational patterns of the relative abundance of specific microbial taxa could be partially explained by the oligotrophic-copiotrophic theory. Specifically, two dark-coniferous forests, located at mid-elevation sites, were considered to be oligotrophic habitats, with relatively higher soil C/N ratio and NH4+-N concentrations. As expected, oligotrophic microbial taxa, belonging to the bacterial phyla Acidobacteria and Gemmatimonadetes, and fungal phylum Basidiomycota, were predominant in the two dark-coniferous forests, exhibiting a mid-elevation maximum pattern. In contrast, the broad leaf-Korean pine mixed forest located at the foot of the mountain, Betula ermanii-dominated forest located below the tree line, and alpine tundra at the highest elevation were considered more copiotrophic habitats, characterized by higher substrate-induced-respiration rates and NO3--N concentrations. Microbial taxa considered to be so called copiotrophic members, such as bacterial phyla Proteobacteria and Actinobacteria, and fungal phylum Ascomycota, were relatively abundant in these locations, resulting in a mid-elevation minimum pattern. At finer taxonomic levels, the two most abundant proteobacterial classes, alpha- and beta-Proteobacteria, along with Acidobacteria Gp1, 2, 3, 15, and the Basidiomycotal class of Tremellomycetes were classified with the copiotrophic group. Gamma- and delta-Proteobacteria, Acidobacteria Gp4, 6, 7, 16, and Basidiomycotal class of Agaricomycetes were classified as oligotrophic taxa. This work uses the oligotrophic-copiotrophic theory to explain the elevational distribution pattern of the relative abundance of specific microbial taxa, confirming some of the existing trophic classifications of microbial taxa and expanding on the theory to include a broader range of taxonomic levels.
History of Transnational Voluntary Associations: A Critical Multidisciplinary Review

This review explores the history of transnational voluntary associations, commencing with general patterns before proceeding to cover the history of different sectors in turn, including humanitarianism, science, education, environment, feminism, race, health, human rights, labor, business, standards, professions, culture, peace, religion, and youth. Coverage extends from the late eighteenth century through to the early twenty-first century and spans histories of particular organizations and of particular campaigns in addition to the evolution of broader transnational social movements. Contrasting perspectives on historical evolution are considered, including both linear and cyclical interpretations. The factors underpinning historical changes are explored, including economic, environmental, political, scientific, and social developments. Insights are drawn not only from a transnational historical perspective, but also the many other disciplines that shed light on the subject, such as world sociology. The review also incorporates perspectives from international relations, development studies, peace studies, voluntary sector studies, and women’s studies. It argues that the historical evolution of transnational voluntary associations is longer, less Western in origin and more cyclical than traditionally assumed.
Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women.

OBJECTIVE Postmenopausal estradiol (E(2)) levels vary widely between individuals and this variation is an important determinant of diseases such as osteoporosis. It has been suggested that the estrogen receptor alpha (ESR1) gene may influence peripheral E(2) levels, but the role of common sequence variations in the ESR1 gene is unclear. METHODS In 631 postmenopausal women and 528 men from the Rotterdam Study, a population-based, prospective cohort study of individuals aged 55 years and over, ESR1 PvuII-XbaI haplotypes were determined and correlated with plasma E2 levels. RESULTS In women, haplotype 1 (T-A) was significantly associated with an allele-dose-dependent decrease in E(2). After adjusting for age, body mass index, years since menopause and testosterone levels, plasma E(2) levels decreased by 1.90 pmol/l per allele copy of this haplotype (P < 0.05). Extreme genotypes, representing 23 and 27% of the population, varied by 3.93 pmol/l. No association with plasma testosterone was observed. In a subset of 446 women, no association of genotype with plasma concentrations of dehydroepiandrosterone sulfate, androstenedione or estrone was seen. In men, none of the sex hormone levels was associated with the ESR1 PvuII-XbaI haplotypes. CONCLUSION We have demonstrated a role for genetic variations in the ESR1 gene in determining post-menopausal E(2) levels in women.
Essays on the Cross-section of Returns

This dissertation examines what factors determine the cross-section of returns. It contains three chapters. Chapter 1 investigates whether uncertainty shocks can explain the value premium puzzle. Intuitively, the value of growth options increases when uncertainty is high. As a result, growth stocks hedge against uncertainty risk and earn lower risk premiums than value stocks. An investment-based asset pricing model augmented with timevarying uncertainty accounts for both the value premium and the empirical failure of the capital asset pricing model (CAPM). This study also shows that uncertainty shocks influence cross-sectional investment. Uncertainty has a negative impact on the investment of value firms, while it has a positive impact on the investment of growth firms. Chapter 2 shows that uncertainty shocks can explain the negative relation between idiosyncratic volatility and expected returns in Ang, Hodrick, Xing and Zhang (2006, 2009). The main intuition is that idiosyncratic volatility amplifies the positive impact of uncertainty shocks on the value of growth options. Therefore, everything else being equal, growth stocks with higher idiosyncratic volatilities perform better than growth stocks with lower idiosyncratic volatilities when uncertainty is high, and consequently have lower expected returns. Using an investment-based asset pricing model with time-varying uncertainty, I show that the idiosyncratic volatility puzzle ii exists only in stocks with low book-to-market ratios (growth stocks). The spread in loadings on uncertainty shocks can explain why growth stocks with high idiosyncratic volatilities earn lower average returns than those with low idiosyncratic volatilities. In Chapter 3, co-authored with Kewei Hou, Chen Xue, and Lu Zhang, we handcollect data on total assets and earnings from Moody’s Industrial Manual to extend the sample for the q-factors back to 1926. We also compare the q-factor model with the Carhart (1997) model in capturing anomalies in the long sample.
On the construction of some capacity-approaching coding schemes

This thesis proposes two constructive methods of approaching the Shannon limit very closely. Interestingly, these two methods operate in opposite regions, one has a block length of one and the other has a block length approaching infinity. The first approach is based on novel memoryless joint source-channel coding schemes. We first show some examples of sources and channels where no coding is optimal for all values of the signal-to-noise ratio (SNR). When the source bandwidth is greater than the channel bandwidth, joint coding schemes based on space-filling curves and other families of curves are proposed. For uniform sources and modulo channels, our coding scheme based on space-filling curves operates within 1.1 dB of Shannon's rate-distortion bound. For Gaussian sources and additive white Gaussian noise (AWGN) channels, we can achieve within 0.9 dB of the rate-distortion bound. The second scheme is based on low-density parity-check (LDPC) codes. We first demonstrate that we can translate threshold values of an LDPC code between channels accurately using a simple mapping. We develop some models for density evolution from this observation, namely erasure-channel, Gaussian-capacity, and reciprocal-channel approximations. The reciprocal-channel approximation, based on dualizing LDPC codes, provides a very accurate model of density evolution for the AWGN channel. We also develop another approximation method, Gaussian approximation, which enables us to visualize infinite-dimensional density evolution and optimization of LDPC codes. We also develop other tools to better understand density evolution. Using these tools, we design some LDPC codes that approach the Shannon limit extremely closely. For multilevel AWGN channels, we design a rate 1/2 code that has a threshold within 0.0063 dB of the Shannon limit of the noisiest level. For binary-input AWGN channels, our best rate 1/2 LDPC code has a threshold within 0.0045 dB of the Shannon limit. Simulation results show that we can achieve within 0.04 dB of the Shannon limit at a bit error rate of 10−6 using a block length of 10 7. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)
COMMUNICABLE DISEASE IN THE SOUTH PACIFIC ISLANDS, 1

An outline is given of the pattern of communicable disease in the South Pacific, as far as it is known. Surveillance and research are incomplete and the World Health Organization is assisting in carrying these out. Reporting and laboratory diagnosis of communicable disease are inadequate and sometimes inaccurate. This is being improved. Medical checks for intending migrants from the South Pacific are, in a number of cases, inadequately performed in the country of origin and this situation should be altered. The risks to surrounding developed countries from migrants, temporary workers and returning travellers are not tremendous but they cannot be neglected and vigilance has to be maintained. Tuberculosis importation does present risks, as does that of typhoid. Malaria importation carries risks for Northern Australia. Leprosy poses little real risk to Australia or New Zealand and neither does filariasis. Cholera would have to be watched for closely should there ever be a South Pacific outbreak, but the developed countries around the South Pacific which are cholera‐non‐receptive can control occasional cases. Other than malaria, tuberculosis, typhoid and possibly dengue, problems are thus mainly in the diagnosis and treatment of individuals.
Evaluation of urinary trans-3′-hydroxycotinine as a biomarker of children's environmental tobacco smoke exposure

Abstract The utility of urinary trans-3′-hydroxy cotinine (3HC) as a biomarker of environmental tobacco smoke (ETS) exposure was investigated in comparison with urinary cotinine (COT), the sum (3HC + COT), and ratio of the two nicotine metabolites (3HC/COT). Participants were 150 ETS exposed children (aged 1–44 months) and their parents. Child urine samples were collected during 3weekly baseline assessments and at interviews administered 3, 6, 12, and 18 months after baseline. Findings indicate that 3HC and COT can be measured reliably (rho = 0.96, 0.88) and show equivalent levels of repeated measures stability (rho = 0.71, 0.75). COT, 3HC, and 3HC + COT showed equally strong associations with air nicotine levels, reported ETS contamination, and reported ETS exposure (r=0.60–0.70). The intraclass correlations of 3HC/COT were lower than those for COT or 3HC. Older children had a higher 3HC/COT ratio than younger children (3.5 versus 2.2), and non-Hispanic White children had a higher ratio than African-American children (3.2 versus 1.9). These findings suggest that COT, 3HC, and 3HC + COT are approximately equivalent and equally strong biomarkers of ETS exposure in children. Moreover, 3HC/COT may provide a useful indicator to investigate age- and race-related differences in the metabolism of COT and 3HC.