Miracle-dz/UniFAR-FTUs huggingface dataset:
The influence of resonant leadership on the structural empowerment and job satisfaction of registered nurses

The demanding nature of nursing work environments signals longstanding and growing concerns about nurses' health and job satisfaction and the provision of quality care. Specifically in healthcare settings, nurse leaders play an essential role in creating supportive work environments to avert these negative trends and increase nurse job satisfaction. The purpose of this study was to examine the influence of managers' resonant leadership on nurses' structural empowerment and job satisfaction. A secondary analysis of data collected from a cross-sectional survey design of 1216 registered nurses from nine Canadian provinces was conducted. Structural empowerment partially mediated the relationship between resonant leadership and job satisfaction. Resonant leadership and structural empowerment explained a total of 36% of the variance in job satisfaction while controlling for age, education and work setting (F(5, 1169) = 131.78, p < 0.001). Findings suggested that resonant leaders are instrumental in creating empowering environments that contribute to higher job satisfaction in nursing. Therefore, a focus on developing resonant leadership skills among nurse leaders in healthcare organisations will advance the creation of healthy work environments that promote job satisfaction and the retention of nurses.
Bis{μ4-N-[phenyl(pyridin-2-ylazanidyl)methyl]pyridin-2-aminido}tetrakis(tetrahydrofuran)tetralithium

The title complex, [Li4(C17H14N4)2(C4H8O)4], bears a novel tetradentate diamido ligand. In the tetranuclear centrosymmetric complex molecule, the metal atoms exhibit two kinds of coordination modes. The middle two Li+ cations are coordinated by four N (ligand) and one O (tetrahydrofuran, THF) atoms, resulting in a distorted square-pyramidal geometry. The outer two Li+ cations are in distorted tetrahedral environments consisting of three N (ligand) and one O (THF) atoms. The Li—N bond lengths vary from 2.020 (7) to 2.441 (6)Å.
2-(5-Bromopyridin-3-yl)-5-[3-(4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-ylsulfonyl)thiophen-2-yl]-1,3,4-oxadiazole

In the title compound, C18H13BrN4O3S3, the tetrahydropyridine ring adopts a half-chair conformation with the central methylene-C atom of the NCH2CH2 unit at the flap. The dihedral angles between the tetrahydropyridine ring and the pyridine and two thiophene rings are 69.34 (13) 5.66 (13) and 68.63 (13)°, respectively, while the dihedral angle between the 1,3,4-oxadiazole and tetrahydropyridine rings is 54.76 (13)°. The molecule is stabilized by an intramolecular C—H⋯N interaction. In the crystal, adjacent molecules are connected via bifurcated C—H⋯(N,O) hydrogen bonds, forming a chain along the b axis.
Caracterización de las reintervenciones en cirugía general Characterization of the reoperations in general surgery

Introduction: in spite of the advance in the current diagnostic and therapeutic methods, the morbidity and mortality caused by reoperations due to postoperative complications continue to be high. Objectives: to characterize reoperated patients according to selected variables and to identify the mortality levels. Methods: an observational and descriptive study of 172 reoperated cases was carried out in the Service of General Surgery from "Saturnino Lora Torres" Clinical Surgical Teaching Provincial Hospital in Santiago de Cuba, during the five year period 20072011. Results: most of the reoperations were carried out during the first week of the postoperative period to patients of the male sex with advanced ages and whose initial
The communication process in family planning in a West Bengal village.

In order to study the communication patterns among adopters and nonadopters of family planning methods the role of mass media and interpersonal communication and the effectiveness of communication channels a survey was conducted of all the households in the village of Nagdaha in the 24-Parganas district of West Bengal. This village is multiethnic with 17 different castes other than Muslims 186 households and a population of 1117. The relevant data on communication relating to family planning was obtained from eligible couples through interview schedules and depth interviews conducted between June 1974-October 1975. It was found that the mass media are considerably more effective for disseminating ideas regarding the family planning programs but interpersonal communication is more effective for transmitting knowledge of actual family planning methods to the people. The contraceptors in the study were largely male who had greater access to both mass media (37%) and interpersonal (30.4%) channels of communication. The study revealed that the adoption of a family planning method is limited by economic illiteracy psychological and religious factors. If the economic level is too high despite literacy it appears to make the individual particularly in rural areas reluctant to use family planning methods. On the basis of this study it can be concluded that most individuals belonging to the middle group are among those using family planning devices for they are both largely literate and under some economic pressure. Despite the literacy of those in the higher group their high economic status somehow keeps them from adopting family planning. The individual in the lower group is influenced by religious and psychological factors along with illiteracy that prevent him/her from using a family planning method. Additionally those in the lower group have a desire for more children because more children means a higher earning capacity.
Population Pharmacokinetics of Danofloxacin After Single Intramuscular Dose Administration in California Brown Pelicans (Pelecanus occidentalis californicus)

Abstract: The pharmacokinetics of danofloxacin was investigated in rehabilitated California brown pelicans (Pelecanus occidentalis californicus) after a single intramuscular injection at a dose of 15 mg/kg body weight. The concentration of the drug in plasma was assayed by high-pressure liquid chromatography. A sparse-sampling design was used to reduce the number of samples (1–4 venipunctures) obtained from 24 brown pelicans. A population pharmacokinetic analysis with nonlinear mixed-effects modeling was used to accommodate the sparse-sampling strategy. The nonlinear mixed-effects modeling approach measured both fixed effects (typical values for the population) and random effects (between-subject variability) for this population. A 1-compartment model best represented the concentration-versus-time data after injection. After injection, the elimination half-life, peak concentration, area under the curve, and volume of distribution were 2.76 hours, 2.5 µg/mL, 13.75 µg/h/mL, and 4.35 L/kg, respectively. Rate of absorption was highly variable among the birds. The intramuscular injection of danofloxacin in pelicans at this dose produced plasma concentrations that meet therapeutic targets for bacteria with a minimum inhibitory concentration of ≤0.25 µg/mL. This dose can be used for future studies to evaluate the efficacy of danofloxacin for treating susceptible bacteria.
Risk factors analysis for development of chronic postsurgical pain after modified radical mastectomy: A single-centered, prospective, observational study

Background: The “chronic post-surgical pain” (CPSP) is defined as pain of at least 2 months duration which has developed after a surgical procedure when other causes such as disease recurrence or preexisting pain syndromes are ruled out. The incidence of CPSP is found maximum after amputation surgeries (50%–85%), followed by thoracotomy (30%–50%) and mastectomy. The aim of our study is to analyze the risk factors such as preoperative pain, anxiety, and specific surgical techniques for development of CPSP after modified radical mastectomy (MRM). Materials and Methods: A total of thirty patients undergoing MRM satisfying inclusion criteria were enrolled out, of which one patient died during the study period of 1 year. Preoperative pain evaluation was done with Visual Analog Scale, and for measuring preoperative anxiety, Hamilton Anxiety Rating Scale was used. Medical and surgical records were studied for evaluation of some postoperative parameters. Appropriate statistical tests were used to evaluate the relationship of different risk factors for development of CPSP. Results: Incidence proportion of CPSP in our study was approximately 24%. All the risk factors we analyzed, i.e. preoperative pain and anxiety, surgical techniques like preservation of intercostobrachialis nerve, type of surgical incision, and duration of surgery were found to be statistically insignificant for development of CPSP. Conclusion: In conclusion, one should be very cautious to identify women who are at risk of developing CPSP or who have already developed CPSP. Establishing a prediction model based on known risk factors to identify susceptible patients and applying protective measures are important steps toward preventive, personalized health care.
Serum Amyloid A Activation of Inflammatory and Adhesion Molecules in Human Coronary Artery and Umbilical Vein Endothelial Cells

Inflammation is considered to be the driving force leading to atherogenic and atherosclerotic mechanisms. Increased levels of SAA predict the risk of coronary artery disease and even mortality from cardiovascular disease in humans. Recent animal and human studies have indicated that SAA plays a causal role in atherogenesis, although it is largely unclear how this occurs. The objectives of this study are to understand the role of SAA in activating possible atherogenic inflammatory responses in human coronary artery endothelial cells (HCAEC) and to compare them with human umbilical vein endothelial cells (HUVEC). Our hypothesis is that vein and artery endothelial cells have different expression patterns and levels, leading to differential inflammatory responses. HUVEC and HCAEC were grown in order to analyze the effects of SAA on endothelial expression of pro-inflammatory cytokines, such as IL-6, chemokines, such as IL-8, and adhesion molecules (s-ICAM, s-VCAM, E-selectin) by reverse transcription-PCR and ELISAs. We compared the dose responses of SAA between HUVEC and HCAEC. SAA activated both HUVEC and HCAEC pro-inflammatory factors in a dose-dependent manner. In comparison however, HCAEC showed a strikingly greater sensitivity to SAA, with a higher level of expression of all pro-inflammatory markers at much lower concentrations of SAA, and their much greater stimulation at higher SAA concentrations. SAA also generated a dose-dependent positive feedback response on its own mRNA expression in HCAEC as compared to HUVEC. In summary, there are distinct significant differences in the levels of inflammatory markers and adhesion molecules between HUVEC and HCAEC SAA induced dose responses that could potentially account for HCAEC greater susceptibility to inflammation and atherogenesis.
Pain relief following arthroscopy: A comparative study of intra-articular bupivacaine, neostigmine, and clonidine

Background and Aims: Quality pain relief after arthroscopic knee surgery is not only a challenge but also a necessity for adequate postoperative rehabilitation after anterior cruciate ligament (ACL) repair. In the past, different agents were tried for pain relief by parenteral and intra-articular routes with varying results. The aim of the present study is to compare the analgesic effects of intra-articularly instilled bupivacaine, clonidine, and neostigmine in the postoperative period after ACL repair. Methods: This was a double-blind study on three groups of patients, wherein bupivacaine, clonidine, or neostigmine was instilled intra-articularly at the end of knee arthroscopic ACL repair and the postprocedure pain relief was assessed. All patients received subarachnoid block with the same volume (17.5 mg) of 0.5% bupivacaine heavy. Postoperative pain was assessed with the visual analog scale (VAS), and rescue analgesics were prescribed for a more than tolerable pain. Pain score was observed at definite intervals and rescue doses were charted in crosstabs. Efficiency of the three drugs in question was tested with Bonferroni technique. Results: VAS scores at 2 h, 6 h, and 12 h were lowest with bupivacaine followed by clonidine and neostigmine. The requirement of rescue analgesics was also in the same order. Conclusion: On the basis of this study, we conclude that intra-articularly instilled bupivacaine provides superior and long-lasting analgesia than clonidine and neostigmine.
Intimate Partner Violence

Intimate partner violence (IPV) is a serious, preventable public health problem that occurs in all settings and among all age, socioeconomic, cultural, and religious groups worldwide. The World Health Organization’s most notable multi-country study confirmed that IPV is widespread and that, overwhelmingly, the global burden is borne by women. This preferred term, IPV, describes physical violence, sexual violence, stalking, and/or psychological aggression by a current or former intimate partner. As this term evolves, research indicates that dating violence, specifically teen dating violence, has a similar focus and elements of adultspecific IPV definitions. It is likely to be included in future description updates. It is also important to recognize that the aging population does experience IPV, and it can be difficult to draw a clear distinction between elder abuse and IPV; the dynamics may present differently from younger populations. Intimate partners include current or former spouses (married, common-law, civil union, or domestic partners), boyfriends/girlfriends, dating partners, and ongoing sexual partners. This type of violence occurs among heterosexual, transgender, and same-sex couples and does not require cohabitation or sexual intimacy. Seen across all cultures and populations, IPV may include physical or sexual violence, stalking, neglect, emotional or psychological abuse, financial abuse, or intimidation.
Is the Timing, Pace, and Success of the Monarch Migration Associated With Sun Angle?

A basic question concerning the monarch butterflies’ fall migration is which monarchs succeed in reaching overwintering sites in Mexico, which fail—and why. We document the timing and pace of the fall migration, ask whether the sun’s position in the sky is associated with the pace of the migration, and whether timing affects success in completing the migration. Using data from the Monarch Watch tagging program, we explore whether the fall monarch migration is associated with the daily maximum vertical angle of the sun above the horizon (Sun Angle at Solar Noon, SASN) or whether other processes are more likely to explain the pace of the migration. From 1998 to 2015, more than 1.38 million monarchs were tagged and 13,824 (1%) were recovered in Mexico. The pace of migration was relatively slow early in the migration but increased in late September and declined again later in October as the migrating monarchs approached lower latitudes. This slow-fast-slow pacing in the fall migration is consistent with monarchs reaching latitudes with the same SASN, day after day, as they move south to their overwintering sites. The observed pacing pattern and overall movement rates are also consistent with monarchs migrating at a pace determined by interactions among SASN, temperature, and daylength. The results suggest monarchs successfully reaching the Monarch Butterfly Biosphere Reserve (MBBR) migrate within a “migration window” with an SASN of about 57° at the leading edge of the migration and 46° at the trailing edge. Ninety percent of the tags recovered in Mexico were from monarchs tagged within this window. Migrants reaching locations along the migration route with SASN outside this migration window may be considered early or late migrants. We noted several years with low overwintering abundance of monarchs, 2004 and 2011–2014, with high percentages of late migrants. This observation suggests a possible effect of migration timing on population size. The migration window defined by SASN can serve as a framework against which to establish the influence of environmental factors on the size, geographic distribution, and timing of past and future fall migrations.
Failure of B Cell Tolerance in CVID

Common variable immunodeficiency (CVID) comprises a group of related disorders defined by defects in B cell function and antibody production. Concurrent autoimmune features are common, but the underlying pathogenic mechanisms of autoimmunity in CVID are poorly understood. Overlap in some clinical and laboratory features suggests a shared pathogenesis, at least in part, with systemic lupus erythematosus (SLE). One important part of SLE pathogenesis is loss of B cell tolerance, an aspect that warrants further study in CVID. The study of inherently autoreactive 9G4+ B cells has led to a greater understanding of B cell tolerance defects in lupus. Study of these B cells in CVID has yielded conflicting results, largely due to differences in methodological approaches. In this study, we take a comprehensive look at 9G4+ B cells throughout B cell development in CVID patients and compare patients both with and without autoimmune features. Using flow cytometry to examine B cell subpopulations in detail, we show that only those CVID patients with autoimmune features demonstrate significant expansion of 9G4+ B cells, both in naïve and multiple memory populations. Examination of two autoreactive B cell subsets recently characterized in SLE, the activated naïve (aNAV) and double negative 2 (DN2) B cells, reveals an expanded 9G4+ DN2 population to be common among CVID patients. These results reveal that both multiple central and peripheral B cell tolerance defects are related to autoimmunity in CVID. Furthermore, these data suggest that the autoreactive DN2 B cell population, which has not previously been examined in CVID, may play an important role in the development of autoimmunity in patients with CVID.
Get Noticed to Get Ahead: The Impact of Personal Branding on Career Success

There is a growing amount of attention being brought to personal branding as an effective career behavior, but little is known about the factors that predict personal branding behaviors and their outcomes. In two studies (N = 477) across two distinctly different cultural contexts (Western and Asian) based on a newly developed and validated scale of personal branding, we have examined the antecedents and outcomes of personal branding. The findings confirm that personal branding leads to greater career satisfaction, fully mediated by perceived employability. Career achievement aspiration was the strongest predictor of engaging in personal branding, while career feedback negatively related to personal branding intention and career self-efficacy positively related to personal branding but not to personal branding intention. These findings highlight the importance of personal branding as a contemporary career technique in promoting one’s personal brand identity to achieve beneficial career outcomes.
AltitudeOmics: Spontaneous Baroreflex Sensitivity During Acclimatization to 5,260 m: A Comparison of Methods

Introduction Baroreflex sensitivity (BRS) is essential to ensure rapid adjustment to variations in blood pressure (BP). Spontaneous baroreflex function can be assessed using continuous recordings of blood pressure. The goal of this study was to compare four methods for BRS quantification [the sequence, Bernardi’s (BER), frequency and transfer function methods] to identify the most consistent method across an extreme range of conditions: rest and exercise, in normoxia, hypoxia, hypocapnia, and hypercapnia. Methods Using intra-radial artery BP in young healthy participants, BRS was calculated and compared using the four methods in normoxia, acute and chronic hypoxia (terrestrial altitude of 5,260 m) in hypocapnia (hyperventilation), hypercapnia (rebreathing) and during ramp exercise to exhaustion. Results The sequence and BER methods for BRS estimation showed good agreement during the resting and exercise protocols, whilst the ultra- and very-low frequency bands of the frequency and transfer function methods were more discrepant. Removing respiratory frequency from the blood pressure traces affected primarily the sequence and BER methods and occasionally the frequency and transfer function methods. Discussion/Conclusion The sequence and BER methods contained more respiratory related information than the frequency and transfer function methods, indicating that the former two methods predominantly rely on respiratory effects of BRS. BER method is recommended because it is the easiest to compute and even though it tends to overestimate BRS compared to the sequence method, it is consistent with the other methods, whilst its interquartile range is the smallest.
Orexins/Hypocretins: Key Regulators of Energy Homeostasis

Originally described to be involved in feeding regulation, orexins/hypocretins are now also considered as major regulatory actors of numerous biological processes, such as pain, sleep, cardiovascular function, neuroendocrine regulation, and energy expenditure. Therefore, they constitute one of the most pleiotropic families of hypothalamic neuropeptides. Although their orexigenic effect is well documented, orexins/hypocretins also exert central effects on energy expenditure, notably on the brown adipose tissue (BAT) thermogenesis. A better comprehension of the underlying mechanisms and potential interactions with other hypothalamic molecular pathways involved in the modulation of food intake and thermogenesis, such as AMP-activated protein kinase (AMPK) and endoplasmic reticulum (ER) stress, is essential to determine the exact implication and pathophysiological relevance of orexins/hypocretins on the control of energy balance. Here, we will review the actions of orexins on energy balance, with special focus on feeding and brown fat function.
Application of Machine Learning Methods to Ambulatory Circadian Monitoring (ACM) for Discriminating Sleep and Circadian Disorders

The present study proposes a classification model for the differential diagnosis of primary insomnia (PI) and delayed sleep phase disorder (DSPD), applying machine learning methods to circadian parameters obtained from ambulatory circadian monitoring (ACM). Nineteen healthy controls and 242 patients (PI = 184; DSPD = 58) were selected for a retrospective and non-interventional study from an anonymized Circadian Health Database (https://kronowizard.um.es/). ACM records wrist temperature (T), motor activity (A), body position (P), and environmental light exposure (L) rhythms during a whole week. Sleep was inferred from the integrated variable TAP (from temperature, activity, and position). Non-parametric analyses of TAP and estimated sleep yielded indexes of interdaily stability (IS), intradaily variability (IV), relative amplitude (RA), and a global circadian function index (CFI). Mid-sleep and mid-wake times were estimated from the central time of TAP-L5 (five consecutive hours of lowest values) and TAP-M10 (10 consecutive hours of maximum values), respectively. The most discriminative parameters, determined by ANOVA, Chi-squared, and information gain criteria analysis, were employed to build a decision tree, using machine learning. This model differentiated between healthy controls, DSPD and three insomnia subgroups (compatible with onset, maintenance and mild insomnia), with accuracy, sensitivity, and AUC >85%. In conclusion, circadian parameters can be reliably and objectively used to discriminate and characterize different sleep and circadian disorders, such as DSPD and OI, which are commonly confounded, and between different subtypes of PI. Our findings highlight the importance of considering circadian rhythm assessment in sleep medicine.