Miracle-dz/UniFAR-FTUs huggingface dataset:
Uterine Epithelial Cell Estrogen Receptor Alpha-Dependent and -Independent Genomic Profiles That Underlie Estrogen Responses in Mice1

ABSTRACT Estrogens exert their activity through estrogen receptor alpha (ERalpha) to stimulate hypertrophy and hyperplasia in the uterus. A uterine epithelial ERalpha conditional knockout mouse model (Wnt7aCre+;Esr1f/f or cKO) demonstrated that ERalpha in the epithelial cells was dispensable for an initial uterine proliferative response to 17beta-estradiol (E2) but required for subsequent uterine biological responses. This study aimed to characterize the differential gene expression patterns induced by E2 in the presence or absence of epithelial ERalpha. RNA microarray analysis revealed that approximately 20% of the genes differentially expressed at 2 h were epithelial ERalpha independent, as they were preserved in the cKO uteri. This indicates that early uterine transcripts mediated by stromal ERalpha are sufficient to promote initial proliferative responses. However, more than 90% of the differentially expressed transcripts at 24 h were not regulated in the cKO, indicating that the majority of later transcriptional regulation required epithelial ERalpha, especially those involved in mitosis. This shows that loss of regulation of these later transcripts results in blunted subsequent uterine growth after 3 days of E2 treatment. Additionally, progesterone's ability to inhibit E2-induced epithelial cell proliferation was impaired, consistent with a uterine receptivity defect that contributes to cKO infertility. These transcriptional profiles correlate with our previously observed biological responses, in which the initial proliferative response is independent of epithelial ERalpha and thus dependent on stromal ERalpha, yet epithelial ERalpha is essential for subsequent tissue responsiveness.
Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial.

BACKGROUND Topical application of tranexamic acid to bleeding wound surfaces reduces blood loss in patients undergoing some major surgeries, without systemic complications. The objective of the present trial was to assess the efficacy and safety of the topical application of tranexamic acid on postoperative blood loss in patients undergoing primary unilateral total knee arthroplasty with cement. METHODS In a prospective, double-blind, placebo-controlled trial, 124 patients were randomized to receive 1.5 or 3.0 g of tranexamic acid in 100 mL of normal saline solution or an equivalent volume of placebo (normal saline solution) applied into the joint for five minutes at the end of surgery. The primary outcome was blood loss calculated from the difference between the preoperative hemoglobin level and the corresponding lowest postoperative value or hemoglobin level prior to transfusion. The safety outcomes included Doppler ultrasound in all patients and measurement of plasma levels of tranexamic acid one hour after release of the tourniquet. RESULTS Twenty-five patients were withdrawn for various reasons; therefore, ninety-nine patients were included in the intention-to-treat analysis. The postoperative blood loss was reduced in the 1.5 and 3-g tranexamic acid groups (1295 mL [95% confidence interval, 1167 to 1422 mL] and 1208 mL [95% confidence interval, 1078 to 1339 mL], respectively) in comparison with the placebo group (1610 mL [95% confidence interval, 1480 to 1738 mL]) (p < 0.017). The postoperative hemoglobin levels were higher in the 1.5 and 3.0-g tranexamic acid groups (10.0 g/dL [95% confidence interval, 9.5 to 10.4 g/dL] and 10.1 g/dL [95% confidence interval, 9.8 to 10.5 g/dL], respectively) in comparison with the placebo group (8.6 g/dL [95% confidence interval, 8.2 to 9 g/dL]) (p < 0.017). With the numbers studied, there was no difference in the rates of deep-vein thrombosis or pulmonary embolism between the three groups. Minimal systemic absorption of tranexamic acid was observed. CONCLUSIONS At the conclusion of a total knee arthroplasty with cement, topical application of tranexamic acid directly into the surgical wound reduced postoperative bleeding by 20% to 25%, or 300 to 400 mL, resulting in 16% to 17% higher postoperative hemoglobin levels compared with placebo, with no clinically important increase in complications being identified in the treatment groups.
Rat osteoclasts adhere to a wide range of rgd (arg‐gly‐asp) peptide‐containing proteins, including the bone sialoproteins and fibronectin, via a β3 integrin

The ligand binding ability of rat osteoclast adhesion receptors was investigated in an attachment assay using osteoclasts disaggregated from bone. Osteoclasts adhered well to the Arg‐Gly‐Asp (RGD)‐containing proteins osteopontin (bone sialoprotein I) and BSP (bone sialoprotein II), vitronectin, fibrinogen, von Willebrand factor, and fibronectin. Osteoclasts also adhered, but less strongly, to type I collagen. No attachment of osteoclasts was observed to thrombospondin, tenascin, laminin, or a range of non‐RGD‐containing bone proteins and proteins from other sources. The attachment of osteoclasts to all ligands was abolished in the presence of GRGDSP peptide, indicating the involvement of the RGD cell binding sequence in ligand binding. Attachment of osteoclasts to all substrates, with the exception of type I collagen, was also strongly inhibited by the addition of monoclonal antibody F11 to the β3 integrin subunit, indicating that a β3 integrin, probably the vitronectin receptor, was involved. Attachment to type I collagen was blocked by EDTA chelation of divalent cations and was not significantly affected by anti‐β3 or anti‐β1 antibodies; when taken with the inhibition by RGD peptide, this suggests the involvement of various receptors, possibly including nonintegrin collagen receptors, in the binding of osteoclasts to this protein. These results define the wide range of ligands for extracellular matrix receptors in osteoclasts in vitro. It remains to be established which of these proteins are important in osteoclast adhesion and osteoclastic bone resorption in vivo.
Casemix funding for acute hospital inpatient services in Australia

Casemix funding was introduced first in Victoria in 1993‐‐94, and since then most States have moved towards either casemix funding or using casemix to inform the budget setting process. The five States implementing casemix have adopted some common funding elements: all use AN‐DRG‐3; all have introduced capping, most commonly at the hospital level; and all ensure accuracy of diagnosis and procedure coding through coding audits. Two funding models have been developed. The fixed and variable model involves a fixed grant for hospital overhead costs and a payment for each patient treated, covering only variable costs. The integrated model provides an integrated payment to hospitals for each patient treated, covering both the fixed and variable costs. There are different weight setting processes and base prices between the States, which result in marked differences in the price paid for the same type of case treated in similar hospitals. Learning across State boundaries should be encouraged, with knowledge of what is effective and what is ineffective in casemix funding arrangements being used to develop Australian best practice in this area.
Energy efficiency performance of distributed antenna systems

This paper presents the energy efficiency gains derived from the use of a distributed antenna system (DAS) in both hotspot and uniform user distribution scenarios. Results show that when remote radio heads (RRH) are placed according to known hotspot locations, energy reduction gains of 12% are observed and -5% in the case of uniform user distribution. DAS deployment planning based on capacity enhancement gives better energy gains than that based on coverage enhancement. It has also shown that RRH location selection based on shadowing information can give better energy performance than that based on signal to interference plus noise ratio (SINR) information in the coverage area.
Price advantage.

Eventually, you will definitely discover a further experience and attainment by spending more cash. nevertheless when? realize you believe that you require to get those all needs past having significantly cash? Why dont you attempt to get something basic in the beginning? Thats something that will lead you to comprehend even more with reference to the globe, experience, some places, in the manner of history, amusement, and a lot more?
Early graft dysfunction and mortality rate in marginal donor liver transplantation.

BACKGROUND/AIM To determine the effect of marginal donor livers on mortality and graft survival in liver transplantation (LT) recipients. MATERIALS AND METHODS Donors with any 1 of following were considered marginal donors: age ≥65 years, sodium level ≥ 165 mmol/L and cold ischemia time ≥ 12 h. Donors were classified according to the donor risk index (DRI) < 1.7 and ≥ 1.7. The transplant recipients' model for end-stage liver disease (MELD) scores were considered low if < 20 and high if ≥ 20. Early graft dysfunction (EGD) and mortality rate were evaluated. RESULTS During the study period 47 patients underwent cadaveric LT. The mean age of the donors and recipients was 45 years (range: 5-72 years) and 46 years (range: 4-66 years), respectively. In all, there were 15 marginal donors and 18 donors with a DRI > 1.7. In total, 4 LT patients that received livers from marginal donors and 5 that received livers from donors with a DRI ≥ 1.7 had EGD. Among the recipients of marginal livers, 5 died, versus 4 of the recipients of standard livers. There was no significant difference in EGD or mortality rate between the patients that received livers from marginal donors or those with a DRI ≥ 1.7 and patients that received standard donor livers. CONCLUSION Marginal and DRI ≥ 1.7 donors negatively affected LT outcomes, but not significantly.
Carbon Assimilation Profiles as a Tool for Identification of Zygomycetes

ABSTRACT Identification of Zygomycetes is difficult and time-consuming by standard microbiological procedures. Carbon assimilation profiles are commonly used for yeast-and bacterial-species identification but rarely for filamentous-fungus identification. Carbon assimilation profiles were evaluated using the commercialized kits ID32C and API 50 CH, which contain 31 and 49 tests, respectively, to serve as simple tools for species identification of Zygomycetes in clinical microbiology laboratories. Fifty-seven strains belonging to 15 species and varieties of Zygomycetes, including Rhizopus, Absidia, Mucor, and Rhizomucor species, were tested for intra- and interspecies variability based on their carbon assimilation profiles. Using ID32C strips, 6 tests were always positive, 7 were never positive, and 18 showed consistently different results between species. With API 50 CH strips, 15 tests were positive for all species, 13 were never positive, and 21 showed different results between species. Nevertheless, assimilation patterns were highly variable among Rhizopus oryzae isolates, and it was not possible to define a specific carbon assimilation profile. With both ID32C and API CH 50 strips, intraspecies variation was found to be low, while large differences were found between genera and species. The clustering of isolates based on their carbon assimilation profiles was in accordance with DNA-based phylogeny of Zygomycetes. In conclusion, carbon assimilation profiles allowed precise and accurate identification of most Zygomycetes to the species level.
Marginal Vertical Discrepancies of Monolithic and Veneered Zirconia and Metal-Ceramic Three-Unit Posterior Fixed Dental Prostheses.

PURPOSE The aim of this study was to investigate and compare the marginal fit of posterior fixed dental prostheses (FDPs) made of monolithic and veneered computer-aided design/computer-assisted manufacture (CAD/CAM) zirconia ceramic with metal-ceramic posterior FDPs. MATERIALS AND METHODS Thirty standardized steel dies were prepared to receive posterior three-unit FDPs. Specimens were randomly divided into three groups (n = 10): (1) metal-ceramic (control group), (2) veneered zirconia, and (3) monolithic zirconia. All FDPs were cemented using a glass-ionomer cement. The specimens were subjected to thermal cycling (5°C to 55°C). A scanning electron microscope (SEM) with a magnification of ×500 was used for measurements. The data were statistically analyzed using one-way analysis of variance and paired t test. RESULTS Both zirconia groups showed similar vertical marginal discrepancies, and no significant differences (P = .661) in marginal adaptation were observed among the groups. No differences were observed in either group in marginal discrepancies between surfaces or abutments. CONCLUSION Monolithic zirconia posterior FDPs exhibit similar vertical marginal discrepancies to veneered zirconia posterior FDPs. No influence of localization measurements was observed.
Supporting the construction of workflows for biodiversity problem-solving accessing secure, distributed resources

In the Biodiversity World (BDW) project we have created a flexible and extensible Web Services-based Grid environment for biodiversity researchers to solve problems in biodiversity and analyse biodiversity patterns. In this environment, heterogeneous and globally distributed biodiversity-related resources such as data sets and analytical tools are made available to be accessed and assembled by users into workflows to perform complex scientific experiments. One such experiment is bioclimatic modelling of the geographical distribution of individual species using climate variables in order to explain past and future climate-related changes in species distribution. Data sources and analytical tools required for such analysis of species distribution are widely dispersed, available on heterogeneous platforms, present data in different formats and lack inherent interoperability. The present BDW system brings all these disparate units together so that the user can combine tools with little thought as to their original availability, data formats and interoperability. The new prototype BDW system architecture not only brings together heterogeneous resources but also enables utilisation of computational resources and provides a secure access to BDW resources via a federated security model. We describe features of the new BDW system and its security model which enable user authentication from a workflow application as part of workflow execution.
Word Association Norms as a Unique Supplement of Traditional Language Resources

The paper deals with reuse and testing of psycholinguistic resources in linguistic studies. We report on the experimental work aiming at comparing and evaluation of linguistic information provided by Word Association Norms (WAN) with that derived from other language resources (LRs), namely corpora and wordnets. Results for 3 European languages: Russian, English and Czech are presented. Quantitative and qualitative outputs of the research show that WAN can be employed to enrich the traditional LRs and serve as a tool for their consistency checking. Introduction It is generally accepted that most today’s NLP applications need quality language resources (LRs), especially those based on real data. The well-established methods gain from large corpora, various dictionaries, lexical semantic networks, databases etc. This paper deals with another kind of LR – Word Association Norms (WAN) that has been neglected, or at least not regularly used in linguistics studies till now. Results of our research clearly show that WAN can be employed to enrich the traditional LRs and serve as a tool for their consistency checking.
Features of Temporomandibular Disorders in Fibromyalgia Syndrome

Abstract This study aimed to investigate the prevalence of clinical features of temporomandibular disorders (TMD) in patients with fibromyalgia. The test group (FMG) consisted of 40 women with fibromyalgia (FM) compared to the control group of 40 healthy subjects using the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). The variables were compared using Fisher’s exact test and a Mann-Whitney test. Facial pain was reported by 85% of the FM group, and 77.5% were diagnosed with myofascial TMD. Muscle pain during jaw movements, daytime bruxism/clenching, and limited mouth opening were significantly higher in the test group. There was no difference between groups in: 1. joint noises; 2. sleep bruxism/clenching; and 3. excursive or non-excursive movements. Classic signs of TMD, such as joint noise and self-reporting of clenching at night, are not associated with fibromyalgia syndrome as demonstrated in the current study. However, the self-reported daytime parafunctions, muscle pain in jaw movements, and limited mouth opening are features of the patients in the current study. This study revealed specific muscle involvement of TMD is also presence in FM.
In vivo animal histomorphometric study for evaluating biocompatibility and osteointegration of nano-hydroxyapatite as biomaterials in tissue engineering.

UNLABELLED The coming decade will bring new and even more complex advances that will transform oral and maxillofacial surgery practice if the specialty is capable of transferring the advances of basic science into clinical practice. Such advances include those in tissue engineering and nanotechnology. Three groups of eight animals (rats), each was evaluated by grouting bone graft substitutes into 3 mm holes that were made into the anteromedialtibialmetaphyses of rats. Two different formulations varying as to the type of hydroxyapatite (HA) were used; Group 1: Nano-hydroxyapatite, Group 2: Control with HA only. Group 3: Control without any bone graft substitutes (empty defects). Animals of each of the three groups were sacrificed in groups of eight at postoperative week four. Histologic analysis revealed superior biocompatibility and osteointegration of bone graft substitutes when nanohydroxyapatite was employed. At four weeks, there was more reactive new bone formation in this group when compared to the hydroxyapatite group. The control group showed incomplete closure of the defect. This study demonstrated that nano-hydroxyapatite improves the bioactivity of bone implant and repair materials. Nanohydroxyapatite has good biocompatibility, finer mechanical properties, adjustable degradation properties, good osteointegration and offers a wide range of potential applications in the tissue engineering. KEY WORDS Osteointegration- Nano-Hydroxyapatite- Biomaterials- Tissue engineering.
High prevalence of quinolone resistance in Neisseria gonorrhoeae in coastal Kenya

Untreated or inadequately treated gonorrhoea is associated with significant morbidity and may act as a co-factor in HIV transmission. The WHO currently recommends treatment of gonorrhoea with quinolone, oral cefixime, intramuscular ceftriaxone or spectinomycin. In Kenya, syndromic treatment of male dysuria or discharge includes presumptive treatment for gonorrhoea with quinolone and …
Limited Stress Response in Streptococcus pneumoniae

In Streptococcus pneumoniae, heat shock induces the synthesis of 65‐, 73‐, and 84‐kDa proteins, and ethanol shock induces a 104‐kDa protein. In this study, the 65‐, 84‐, and 104‐kDa proteins were identified as members of the GroEL, ClpL and alcohol dehydrogenase families, respectively, and the general properties of the stress response of S. pneumoniae to several other stresses were characterized. However, several stresses which are known to induce stress responses in Escherichia coli and Bacillus subtilis failed to induce any high molecular weight heat‐shock proteins (HSPs) such as GroEL and DnaK homologues. A minor temperature shift from 30 to 37 C triggered induction of the homologues of DnaK and GroEL of E. coli. These features may provide a foundation for evaluating the role of heat‐shock proteins relative to the physiology and pathogenesis of pneumococcus.
Impact of a Medium-Size Wave Farm on Grids of Different Strength Levels

Power fluctuations generated by most oscillating wave energy converters may have a negative impact on the power quality of the local grid to which the wave farms will be connected. Hence, assessing their impact is an important step in the selection process of a suitable deployment location. However, site-specific grid impact assessment studies are relatively time-consuming and require a high level of detail on the local network. Both of these constraints mean that grid impact studies are usually not performed in the preliminary stages of the site selection process, despite the extremely negative consequences resulting from poor power quality. This paper details a comprehensive study based on a relatively typical wave farm design connected to networks of different strength levels. The study was performed using experimental electrical power time series of an oscillating water column (OWC) device generated under the framework of the European FP7 project “CORES”. Simulations were performed using DIgSILENT power system simulator “PowerFactory”.
Securing information flows: A quantitative risk analysis approach

Risk-based information trading systems have recently emerged as a new paradigm for enabling information sharing in dynamic environments. Such systems build an information trading market whose commodity is information (quantized into objects) and whose currency is monetized evaluated risk. In these trading systems, risk is calculated by the information seller (and consequently charged to the information buyer) as a function of the value of the object and an information buyerpsilas propensity to divulge shared information (based on observed past behavior). Whilst standard techniques exist for evaluating the value of an object, determining the propensity of a buyer to leak information is somewhat more problematic. Ostensibly, a seller could rely on static pre-assigned credentials of the buyer, however, such credentials only provide a clue as to the buyerpsilas ldquotrustworthinessrdquo at the time of credential issuance and gives no indication of post-issuance behavior. In this paper, we propose the use of a information leakage monitoring subsystem as part of a larger risk trading system to detect information leakage. We propose a framework for the design of such a subsystem and identify the fundamental tradeoffs between maximum information leakage rates, delays in leakage detection, buyer budgetary constraints and inherent errors in the monitoring subsystem.
Constant rate adaptive modulation with selection transmit diversity for broadband OFDM systems

Adaptive modulation combined with transmit diversity can achieve further increases in system's capacity and bandwidth efficiency, as well as in QoS improvement in conventional OFDM systems. In this paper, we propose a constant rate adaptive modulation with selection transmit diversity for broadband OFDM wireless systems. By combining the adaptive modulation with the adaptive selection diversity according to the characteristics of the channel on each sub-carrier, the transmit diversity obtained by antenna selection is further maximized through adaptive bit assignment and power assignment on each sub-carrier under the constraint of power and overall bit rate. As a result, the proposed system can achieve better performance compared to that of the conventional selection transmit diversity based OFDM systems without adaptive modulation and conventional adaptive modulation based OFDM systems without selection transmit diversity over multipath fading channels.