Miracle-dz/UniFAR-FTUs huggingface dataset:
Performance improvement of improved practical control method for two-mass PTP positioning systems in the presence of actuator saturation

The positioning systems generally need a good controller to achieve a fast response, high accuracy and robustness. In addition, ease and simplicity of controller design structure are very important for practical applications. For satisfying these requirements, NCTF controller has been proposed as a practical control method for two-mass rotary PTP positioning systems. However, the effect of the actuator saturation cannot be completely compensated due to integrator windup when the object parameter varies. This paper presents a method to further improve NCTF controller to overcome the problem of integrator windup. The improved NCTF controller is evaluated experimentally using rotary two-mass positioning system. The effect of the design parameters on the robustness of the improved NCTF with anti-windup integrator controller is evaluated and compared with NCTF without anti-windup integrator and the equivalent PID controller. The results show that the improved NCTF controller is effective to compensate the effect of integrator windup.
Mmicular mechanisms of cytochrome c biogenesis: three distinct systems

The past 10 years have heralded remarkable progress in the understanding of the biogenesis of c‐type cytochromes. The hallmark of c‐type cytochrome synthesis is the covalent ligation of haem vinyl groups to two cysteinyl residues of the apocytochrome (at a Cys–Xxx–Yyy–Cys–His signature motif). From genetic, genomic and biochemical studies, it is clear that three distinct systems have evolved in nature to assemble this ancient protein. In this review, common principles of assembly for all systems and the mmicular mechanisms predicted for each system are summarized. Prokaryotes, plant mitochondria and chloroplasts use either system I or II, which are each predicted to use dedicated mechanisms for haem delivery, apocytochrome ushering and thioreduction. Accessory proteins of systems I and II co‐ordinate the positioning of these two substrates at the membrane surface for covalent ligation. The third system has evolved specifically in mitochondria of fungi, invertebrates and vertebrates. For system III, a pivotal role is played by an enzyme called cytochrome c haem lyase (CCHL) in the mitochondrial intermembrane space.
[ASSOCIATION OF POLYMORPHIC MARKERS IN GENES OF INNATE IMMUNITY IN PATIENTS WITH PERIODONTITIS AND INFLAMMATORY DISEASES OF UPPER RESPIRATORY TRACT].

AIM Search of association of polymorphisms in DEFB1, IL-10, TNF-α and TLR2 genes with development of chronic generalized periodontitis in representatives of Ural region (Caucasian race). MATERIALS AND METHODS 142 patients, that were split into 3 groups, took part in the study: a group of patients with periodontitis, a group with frequent inflammatory disease of upper respiratory tract and a comparison group--healthy donors. A study of polymorphic markers was carried out: DEFB1 (-44G/C), DEFB1 (-20A/G), IL-10 (-1082.A/G), TNF-α (-308 G/A), Arg753Gln and Arg677Trp using PCR in real time mode. RESULTS Association of infectious pathology ofupper respiratory tract and development of periodontitis diseases with markers in DEFB1 (-44G/C) and Arg753Gln and Arg677Trp genes was determined. Significant differences in distribution of genotypes and alleles of genes IL-10 and TNF-α in the group of patients with periodontitis and comparison group were not detected. CONCLUSION DEFB1 (-44G/C) polymorphism can be examined as a marker of periodontitis development risk.
The genetics of asthma and atopy

Asthma is a respiratory disease that is characterized by variable airways obstruction, airways inflammation, and bronchial hyperresponsiveness (BHR) (1). Most patients with asthma have clinical and serologic evidence of atopy. Even in children who are asymptomatic, BHR appears to be closely linked to an allergic diathesis, as reflected by the association of serum IgE level with BHR and asthma (2). These flndings suggest a close relationship between asthma and atopy. There has been a recent increase in morbidity associated with asthma (3), and epidemiologic studies have provided strong evidence that asthma and allergic disorders are increasing both in prevalence and severity (4, 5). While the precise reasons for these changes are unknown, some evidence indicates that these rising trends are associated with increased levels of sensitization to common environmental allergens and early-life exposure to adjuvant factors including air pollutants and viruses in susceptible individuals (6). Understanding the genetic mechanisms responsible for allergy and asthma has widespread public health consequences, as it may lead to improved preventive measures and new therapeutic approaches. This review will discuss the general approaches used in genetic studies and methodologic difficulties, as well as current flndings that demonstrate the recent advances in understanding the genetics of asthma and atopy. Approaches in genetic studies
HOx chemistry during INTEX-A 2004: Observation, model calculation, and comparison with previous studies

OH and HO_2 were measured with the Airborne Tropospheric Hydrogen Oxides Sensor (ATHOS) as part of a large measurement suite from the NASA DC-8 aircraft during the Intercontinental Chemical Transport Experiment-A (INTEX-A). This mission, which was conducted mainly over North America and the western Atlantic Ocean in summer 2004, was an excellent test of atmospheric oxidation chemistry. The HOx results from INTEX-A are compared to those from previous campaigns and to results for other related measurements from INTEX-A. Throughout the troposphere, observed OH was generally 0.95 of modeled OH; below 8 km, observed HO_2 was generally 1.20 of modeled HO_2. This observed-to-modeled comparison is similar to that for TRACE-P, another midlatitude study for which the median observed-to-modeled ratio was 1.08 for OH and 1.34 for HO_2, and to that for PEM-TB, a tropical study for which the median observed-to-modeled ratio was 1.17 for OH and 0.97 for HO_2. HO_2 behavior above 8 km was markedly different. The observed-to-modeled HO_2 ratio increased from ∼1.2 at 8 km to ∼3 at 11 km with the observed-to-modeled ratio correlating with NO. Above 8 km, the observed-to-modeled HO_2 and observed NO were both considerably greater than observations from previous campaigns. In addition, the observed-to-modeled HO_2/OH, which is sensitive to cycling reactions between OH and HO_2, increased from ∼1.5 at 8 km to almost 3.5 at 11 km. These discrepancies suggest a large unknown HO_x source and additional reactants that cycle HO_x from OH to HO_2. In the continental planetary boundary layer, the observed-to-modeled OH ratio increased from 1 when isoprene was less than 0.1 ppbv to over 4 when isoprene was greater than 2 ppbv, suggesting that forests throughout the United States are emitting unknown HO_x sources. Progress in resolving these discrepancies requires a focused research activity devoted to further examination of possible unknown OH sinks and HO_x sources.
Hammondia triffittae n. comb. of foxes (Vulpes spp.): biological and molecular characteristics and differentiation from Hammondia heydorni of dogs

SUMMARY Genomic DNAs from 3 oocyst isolates of Hammondia sp. from foxes (Vulpes vulpes and V. lagopus) and 1 oocyst isolate of Hammondia heydorni from a dog, were examined by PCR and sequence analysis of 6 loci in order to determine whether the isolates were conspecific. Consistent genetic differences were found between the fox and dog isolates, respectively, at the ITS-2 region, the lsu rRNA gene, the alpha tubulin gene and the HSP70 gene, but not at the ssu rRNA gene or ITS-1 locus. Infection experiments established that dogs were unsuitable as definitive hosts for Hammondia sp. of foxes; hence this species is regarded as separate from H. heydorni of wolf-like canids, but probably identical with Isospora triffittae (syn. Isospora triffitti) previously reported from foxes. This species has therefore been named Hammondia triffittae n. comb. Reindeer, moose, sheep, goats, foxes and rabbits may act as intermediate hosts for H. triffittae. Muscle tissues of inoculated intermediate hosts were infectious for foxes from 16 days post-infection. Oocysts of H. triffittae were subspherical, averaging 12·5×10·9 μm in size. The lsu rRNA gene and the alpha tubulin gene seem to be suitable genetic markers for differentiating between H. triffittae and H. heydorni.
Comparison of Sociodemographic and Nutritional Characteristics between Self-Reported Vegetarians, Vegans, and Meat-Eaters from the NutriNet-Santé Study

Background: There is a growing trend for vegetarian and vegan diets in many Western countries. Epidemiological evidence suggesting that such diets may help in maintaining good health is rising. However, dietary and sociodemographic characteristics of vegetarians and vegans are not well known. The aim of this cross-sectional study was to describe sociodemographic and nutritional characteristics of self-reported, adult vegetarians and vegans, compared to meat-eaters, from the French NutriNet-Santé study. Methods: Participants were asked if they were following a specific diet. They were then classified into three self-reported diet groups: 90,664 meat-eaters, 2370 vegetarians, and 789 vegans. Dietary data were collected using three repeated 24-h dietary records. Multivariable polytomic logistic regression models were perfomed to assess the association between the sociodemographic characteristics and type of diet. The prevalence of nutrient intake inadequacy was estimated, by sex and age for micronutrients, as well as by type of self-reported diet. Results: Compared with meat-eaters, vegetarians were more likely to have a higher educational level, whereas vegans had a lower education level. Compared with meat-eaters, vegetarians were more likely to be women, younger individuals, and to be self-employed or never employed rather than managerial staff. Vegetarians and vegans substituted animal protein-dense products with a higher consumption of plant protein-dense products (e.g., soy-based products or legumes). Vegetarians had the most balanced diets in terms of macronutrients, but also had a better adherence to French dietary guidelines. Vegetarians exhibited a lower estimated prevalence of inadequacies for micronutrients such as antioxidant vitamins (e.g., for vitamin E, 28.9% for vegetarian women <55 years of age vs. 41.6% in meat-eaters) while vegans exhibited a higher estimated prevalence of inadequacies for some nutrients, in particular vitamin B12 (69.9% in men and 83.4% in women <55 years of age), compared to meat-eaters. Conclusions: Our study highlighted that, overall, self-reported vegetarians and vegans may meet nutritional recommendations.
On the Capacity of Radio Communication Systems with Diversity in a Rayleigh Fading Environment

In this paper, we study the fundamental limits on the data rate of multiple antenna systems in a Rayleigh fading environment. With M transmit and M receive antennas, up to M independent channels can be established in the same bandwidth. We study the distribution of the maximum data rate at a given error rate in the channels between up to M transmit antennas and M receive antennas and determine the outage probability for systems that use various signal processing techniques. We analyze the performance of the optimum linear and nonlinear receiver processor and the optimum linear transmitter/receiver processor pair, and the capacity of these channels. Results show that with optimum linear processing at the receiver, up to M/2 channels can be established with approximately the same maximum data rate as a single channel. With either nonlinear processing at the receiver or optimum linear transmitter/receiver processing, up to M channels can be established with approximately the same maximum data rate as a single channel. Results show the potential for large capacity in systems with limited bandwidth.
A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family*

We have previously identified a 160-kDa protein in human embryonic kidney (HEK) 293 cells that undergoes rapid tyrosine phosphorylation in response to insulin (PY160) (Kuhné, M. R., Zhao, Z., and Lienhard, G. E. (1995) Biochem. Biophys. Res. Commun. 211, 190–197). The phosphotyrosine form of PY160 was purified from insulin-treated HEK 293 cells by anti-phosphotyrosine immunoaffinity chromatography, the sequences of peptides determined, and its cDNA cloned. The PY160 cDNA encodes a 1257-amino acid protein that contains, in order from its N terminus, a pleckstrin homology (PH) domain, a phosphotyrosine binding (PTB) domain, and, spread over the C-terminal portion, 12 potential tyrosine phosphorylation sites. Several of these sites are in motifs expected to bind specific SH2 domain-containing proteins: YXXM (7 sites), phosphatidylinositol 3-kinase; YVNM (1 site), Grb-2; and YIEV (1 site), either the protein-tyrosine phosphatase SHP-2 or phospholipase Cγ. Furthermore, the PH and PTB domains are highly homologous (at least 40% identical) to those found in insulin receptor substrates 1, 2, and 3 (IRS-1, IRS-2, and IRS-3). Thus, PY160 is a new member of the IRS family, which we have designated IRS-4.
Influences of ITO anode thickness on OLED efficiencies

In this work, emission characteristics of OLEDs as a function of the ITO anode thickness were investigated theoretically and experimentally. The efficiency characteristics show significant variations (1.34 times in quantum efficiencies, 1.44 times in cd/A efficiencies and 1.51 times in lm/W efficiencies) vs. ITO thickness.
Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett's oesophagus

Objective The value of surveillance for patients with Barrett's oesophagus (BO) is under discussion given the overall low incidence of neoplastic progression and lack of discriminative tests for risk stratification. Histological diagnosis of low-grade dysplasia (LGD) is the only accepted predictor for progression to date, but has a low predictive value. The aim of this study was therefore to evaluate the value of p53 immunohistochemistry for predicting neoplastic progression in patients with BO. Design We conducted a case–control study within a prospective cohort of 720 patients with BO. Patients who developed high-grade dysplasia (HGD) or oesophageal adenocarcinoma (OAC) were classified as cases and patients without neoplastic progression were classified as controls. P53 protein expression was determined by immunohistochemistry in more than 12 000 biopsies from 635 patients and was scored independently by two expert pathologists who were blinded to long-term outcome. Results During follow-up, 49 (8%) patients developed HGD or OAC. P53 overexpression was associated with an increased risk of neoplastic progression in patients with BO after adjusting for age, gender, Barrett length and oesophagitis (adjusted relative risks (RRa) 5.6; 95% CI 3.1 to 10.3), but the risk was even higher with loss of p53 expression (RRa 14.0; 95% CI 5.3 to 37.2). The positive predictive value for neoplastic progression increased from 15% with histological diagnosis of LGD to 33% with LGD and concurrent aberrant p53 expression. Conclusions Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with BO and appears to be a more powerful predictor of neoplastic progression than histological diagnosis of LGD.
Prediction of Surgical Outcome by Interictal Epileptiform Abnormalities During Intracranial EEG Monitoring in Patients with Extrahippocampal Seizures

Summary: Purpose: Ictal intracranial EEG recordings obtained during continuous preoperative monitoring are often used to localize the region of seizure onset for purposes of surgical resection in patients with extrahippocampal seizures. Whether interictal epileptiform abnormalities during long‐term monitoring can predict surgical outcome in this group is not established.
Rapid transfer of hydride ion from a ruthenium complex to C1 species in water.

Solvent water (Gutmann acceptor number, AN = 55) accelerates the rate of reaction of Ru(terpy)(bpy)H+ with CO2 by more than 4 orders of magnitude compared to acetonitrile (AN 18.9) (as reported in Inorg. Chim. Acta 2000, 299, 155). Water also promotes the related reductions of carbon monoxide to formaldehyde and of formaldehyde to methanol by the ruthenium(II) hydride complex.
Immigration et marché du travail en Italie : données récentes

L'immigration recente et le marche de l'emploi en Italie Alessandra VENTURINI Le propos de cet article est d'analyser les effets de la recente immigration des pays developpes sur le marche du travail italien. Cette observation comprend deux parties : la premiere concerne le phenomene dans son ensemble. On y presente notamment une interpretation des effets de cette immigration recente sur le marche du travail, d'ou il ressort l'existence et le developpement d'une economie parallele. Une fois etablie les conditions du marche du travail des pays de depart, on montre la difficulte a prevoir une diminution de la segmentation du marche de l'emploi dans le pays d'arrivee. La seconde partie concerne une analyse precise de l'ensemble italien avec une attention particuliere aux nouvelles lois et a la politique migratoire du pays.
MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine.

AIMS The C3435T polymorphism in the human MDR1 gene is associated with lower intestinal P-glycoprotein expression, reduced protein function in peripheral blood cells and higher plasma concentrations of the P-glycoprotein substrate digoxin. Using fexofenadine, a known P-glycoprotein substrate, the hypothesis was tested whether this polymorphism also affects the disposition of other drugs in humans. METHODS Ten Caucasian subjects homozygous for the wild-type allele at position 3435 (CC) and 10 individuals homozygous for T at position 3435 participated in this study. A single oral dose of 180 mg fexofenadine HCl was administered. Plasma and urine concentrations of fexofenadine were measured up to 72 h using a sensitive LC/MS method. In addition, P-glycoprotein function was assessed using efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ cells. Results Fexofenadine plasma concentrations varied considerably among the study population. However, fexofenadine disposition was not significantly different between the CC and TT groups (e.g. AUC(0,infinity) CC vs TT: 3567.1+/-1535.5 vs 3910.1+/-1894.8 ng ml-1 h, NS; 95% CI on the difference -1364.9, 2050.9). In contrast, P-glycoprotein function was significantly decreased in CD56+ cells of the TT compared with the CC group (rhodamine fluorescence CC vs TT: 45.6+/-7.2% vs 61.1+/-12.3%, P<0.05; 95% CI on the difference 5.6, 25.5). Conclusions In spite of MDR1 genotype-dependent differences in P-glycoprotein function in peripheral blood cells, there was no association of the C3435T polymorphism with the disposition of the P-glycoprotein substrate fexofenadine in this German Caucasian study population. These data indicate that other mechanisms including uptake transporter function are likely to play a role in fexofenadine disposition.
Influence of Root Pruning on Stem and Root Morphology of Poplar (Populus deltoides) Clones

The fast growing tree species of choice belong to genus Populus which belongs to family Salicaceae.To fulfill the increasing demand for forest products, fast-growing trees such as poplar are grown on the managed plantations and are being seriously considered for future supply needs. Poplars are widely grown for its multipurpose uses. Populus includes the specie eastern cottonwood (P. deltoides) often characterized as fast-growing, moisture-loving, and shade-intolerant medium to large trees with a short life span. Cottonwood can be naturally regenerated usually by seeds. They can be also propagated by the usual of vegetative reproduction. They mostly occur in the low lying moist alluvial grounds tolerate flooding for a short time during the rainy season and can be propagated vegetatively. Poplars are one of the most easily cloned woody species, which allows for greater availability of promising crosses. Numerous methods are available for regulating vegetative growth in deciduous tree species (Miller and Tworkoski, 2003). It has been used as a horticultural practice to produce sturdier trees, force development of a more compact fibrous root system, retard top growth and increase transplant survival and post transplant growth (Mullin, 1988). Root systems with numerous laterals roots are one of the most essential attributes of high quality seedlings (Aldhus, 1994). Moreover, the form International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 4 (2017) pp. 1482-1487 Journal homepage: http://www.ijcmas. com
Impact of different dietary approaches on blood pressure in hypertensive and prehypertensive patients: protocol for a systematic review and network meta-analysis

Introduction Lifestyle modification is one of the cornerstones in the management of hypertension. According to the most recent guidelines by the American Heart Association, all patients with hypertension should adopt the following dietary advices: increased consumption of fresh fruits, vegetables, low-fat dairy products and sodium reduction. The aim of the present study is to assess the efficacy of different dietary approaches on systolic and diastolic blood pressure in patients with hypertension and high normal blood pressure in a systematic review including a pairwise and network meta-analysis of randomised trials. Methods and analysis We conducted searches in Cochrane Central Register of Controlled Trials in the Cochrane Library, PubMed and Google Scholar until November 2016. Citations, abstracts and relevant papers were screened for eligibility by two reviewers independently. Randomised trials were included if they met the following criteria: (1) hypertension (as mean values ≥140 mm Hg systolic blood pressure and/or ≥90 mm Hg diastolic blood pressure) or high normal blood pressure (mean systolic blood pressure ≥130 mm Hg and/or mean diastolic blood pressure ≥85 mm Hg), (2) age ≥18 years, (3) intervention diets (different type of dietary approaches, eg, dietary approach to stop hypertension diet; Mediterranean diet, vegetarian diet, palaeolithic diet, low sodium diet) either hypocaloric, isocaloric or ad libitum diets, (4) intervention period ≥12 weeks. For each outcome measure of interest, random effects pairwise and network meta-analyses were performed in order to determine the pooled relative effect of each intervention relative to every other intervention in terms of the postintervention values (or change scores). Subgroup analyses were planned for hypertensive status, study length, sample size, age and sex. Ethics and dissemination As this study is based solely on the published literature, no ethics approval was required. We published our network meta-analysis in a peer-reviewed scientific journal. Systematic review registration PROSPERO: CRD42016049243
Softening the blow of frequent sequence analysis: soft constraints and temporal accuracy

Mining temporal knowledge has many applications. Such knowledge can be all the more interesting as some time constraints between events can be integrated during the mining task. Both in data mining and machine learning, some methods have been proposed to extract and manage such knowledge using temporal constraints. In particular, some work has been done to mine Generalised Sequential Patterns (GSPs). However, such constraints are often too crisp or need a very precise assessment to avoid erroneous information. Within this context, we propose an approach based on sequence graphs derived from soft temporal constraints. These relaxed constraints enable us to find more GSPs. We also propose a temporal accuracy measure to provide the user with a tool for analysing the numerous extracted patterns.