Miracle-dz/UniFAR-FTUs huggingface dataset:
“In the United States, we say, ‘No breastfeeding,’ but that is no longer realistic”: provider perspectives towards infant feeding among women living with HIV in the United States

Currently, the United States (U.S.) recommends that infants born to women living with HIV (WLHIV) be fed formula, whereas many low‐resource settings follow the World Health Organization's recommendation to exclusively breastfeed with ongoing antiretroviral therapy. Evidence on infant feeding among WLHIV in high‐resource countries suggest that these contrasting recommendations create challenges for providers and patients. Our study used multiple methods to understand providers’ infant feeding perspectives on caring for their pregnant and post‐partum WLHIV in the U.S.
Ensuring specification correctness by construction

We propose a process model for the development of formal and semi-formal specifications based on the notions of multi-view states and development operators. A specification state is composed of a UML and a B view. The development of a specification is seen as a sequence of application of operators, which model design decisions and make both views evolve. To produce consistent specifications, we define a consistency relation between views, allowing to define and check operators' correctness. Thus, the development process guarantees that the specification can be safely verified.
Detection of structural abnormalities in fetuses with normal karyotype at 11–13 weeks using the anatomic examination protocol of the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG)

Abstract Objective: To assess the performance of sonography in the detection of fetal nonchromosomal abnormalities using a standard anatomic examination protocol proposed by International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) at 11+0–13+6 weeks. Materials and methods: A prospective observational study was conducted between June 2013–May 2017 in singleton pregnancies attending for a routine scan at 11+0–13+6 weeks. All examinations were performed by maternal-fetal medicine specialists certified by the Fetal Medicine Foundation according to the anatomic examination protocol described in the ISUOG guidelines. First-trimester findings were compared to those of the anomaly scan at 20+0–23+6 weeks and the postnatal examination. The primary outcome was the detection rate of major structural abnormalities in fetuses with normal karyotype at 11+0–13+6 weeks. Results: After excluding 17 chromosomal abnormalities, major fetal structural defects were detected in 57 (1.7%) of the remaining 3361 cases. Of these, 27 (47.3%) were detected at 11+0–13+6 weeks, including all cases of acrania (4), exomphalos (4), megacystis (2) and body stalk anomaly (2). Furthermore, there was a first-trimester diagnosis in 36.4% (4/11) of major cardiac defects, 38% (6/16) of limb defects, and 100% (2/2) of facial clefts. Discussion: Targeted ultrasound examination may identify all the so called “always” detectable major abnormalities and a significant proportion of the “sometimes”, detectable at 11+0–13+6 weeks.
The role of structural genomic variants in population differentiation and ecotype formation in Timema cristinae walking sticks

Theory predicts that structural genomic variants such as inversions can promote adaptive diversification and speciation. Despite increasing empirical evidence that adaptive divergence can be triggered by one or a few large inversions, the degree to which widespread genomic regions under divergent selection are associated with structural variants remains unclear. Here we test for an association between structural variants and genomic regions that underlie parallel host‐plant‐associated ecotype formation in Timema cristinae stick insects. Using mate‐pair resequencing of 20 new whole genomes we find that moderately sized structural variants such as inversions, deletions and duplications are widespread across the genome, being retained as standing variation within and among populations. Using 160 previously published, standard‐orientation whole genome sequences we find little to no evidence that the DNA sequences within inversions exhibit accentuated differentiation between ecotypes. In contrast, a formerly described large region of reduced recombination that harbours genes controlling colour‐pattern exhibits evidence for accentuated differentiation between ecotypes, which is consistent with differences in the frequency of colour‐pattern morphs between host‐associated ecotypes. Our results suggest that some types of structural variants (e.g., large inversions) are more likely to underlie adaptive divergence than others, and that structural variants are not required for subtle yet genome‐wide genetic differentiation with gene flow.
A Region Growing Algorithm Based on Anisotropic Filtering for Image Segmentation of the Liver

According to the characteristics of the liver image and the shortcomings of the traditional region growing algorithm, a modified region growing algorithm is proposed based on the adaptive anisotropic filtering. The first, a anisotropic filtering algorithm is proposed based on adaptive anisotropic filtering and we make images noise reduction through it. Second, we studied a method which can select seeds automatically, then the parameters which are in the region growing algorithm will be obtained through Otsu. These innovations and improvements enable segmentation algorithm automatic, fast, accurate. Experiments show that, the algorithm that this article proposed the region growing based on adaptive image segmentation of the liver, the result is better than the traditional region growing algorithm.
Measuring child social communication across contexts: Similarities and differences across play and snack routines

Improving measurement of outcomes in randomized controlled trials of early interventions for autism spectrum disorder (ASD) has been identified as a priority in the field. In addition, the importance of measurement across contexts has been indicated by researchers and community stakeholders alike [Lord et al., ; McConachie et al., ; Schreibman et al., ]. The Brief Observation of Social Communication Change (BOSCC; Grzadzinski et al., ), an observational rating scheme of brief play interactions, was developed to address a need for measures that are reliable, sensitive to change, and valid for use in research settings. The goal of this study was to examine the feasibility and utility of applying the BOSCC to a new context: a home snack routine. Results suggest that rating the BOSCC on home snack routines is feasible and psychometrically sound, and captures change in child social communication behaviors. However, the utility of the BOSCC for measuring restricted and repetitive behaviors (RRBs) is less clear. Nonetheless, differences in RRBs across play and snack lend support for the claim that measurement across contexts is essential. Application of the BOSCC across contexts may allow researchers to obtain a more accurate estimate of intervention response and help capture context‐specific changes in social communication. It may also provide a method for researchers to evaluate the effect of context on child social communication more broadly. Autism Res 2019, 12: 636–644. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.
Chronic kidney disease predicts atrial fibrillation in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention

Abstract Background: Atrial fibrillation (AF) often complicates ST-segment elevation myocardial infarction (STEMI). Predictors of AF in this setting include factors related to the acute phase of STEMI and pre-existing conditions. More recently, novel AF predictors have been identified in the general population. We aimed to assess the ability of such novel factors to predict STEMI-related AF. Methods: Data were collected from STEMI patients treated by primary PCI. Factors related to the acute phase of STEMI (Killip class, heart rate, blood pressure on admission, post-PCI TIMI flow), classic (age, hypertension, heart failure, previous myocardial infarction), and more novel (body mass index [BMI], diabetes, chronic kidney disease [CKD], chronic obstructive pulmonary disease [COPD]) AF predictors were evaluated. The ability of these novel factors to predict STEMI-related AF was assessed. Results: Of the 629 studied patients, 10.5% presented STEMI-related AF. AF patients had higher Killip class on admission (p < .0001) and lower post-PCI TIMI flow (p < .01), they were older (p < .0001) and more likely to have a history of heart failure (p = .02) and myocardial infarction (p = .04). BMI, history of diabetes and COPD were similar between patients with and without AF (all p > .05), but CKD was more common in AF patients (p < .0001). In multiple regression analysis, CKD remained a strong independent predictor of STEMI-related AF (p < .0001). Conclusion: Irrespective of other factors, CKD was associated with increased risk of STEMI-related AF. CKD could be used to identify patients who will develop AF in this setting and who would benefit from closer follow-up and more intensive prophylactic strategies.
Change in eating disorder symptoms following pediatric obesity treatment

OBJECTIVE The purpose of this study is to evaluate whether children with overweight or obesity participating in an evidence-based treatment, family-based behavioral treatment (FBT) for obesity, or a parent-only variant of FBT (PBT), experience an increase of eating disorder (ED) symptoms during and following treatment. METHOD Children (N = 150) participating in a randomized controlled trial of FBT or PBT completed measures of EDs attitudes and behaviors at baseline, following 6-months of treatment, 6 months, and 18 months after treatment. RESULTS Linear-mixed effects models suggest that ED attitudes did not significantly increase. Rather, significant decreases of shape, weight, and eating concerns were shown following treatment. Loss of control over eating significantly decreased over treatment and follow-up. No participant endorsed purging at any time point. DISCUSSION Results confirm the hypothesis that ED symptoms do not increase after participating in FBT or a FBT-based treatment. These findings should help assuage fears of parents that enrolling their child will exacerbate ED symptoms and aid children to access evidence-based treatments that may help reduce significant physical and psychosocial complications of childhood obesity.
Spatiotemporal quantification of acoustic cell patterning using Voronoï tessellation

Acoustic patterning using ultrasound standing waves has recently emerged as a potent biotechnology enabling the remote generation of ordered cell systems. This capability has opened up exciting opportunities, for example, in guiding the development of organoid cultures or the organization of complex tissues. The success of these studies is often contingent on the formation of tightly-packed and uniform cell arrays; however, a number of factors can act to disrupt or prevent acoustic patterning. Yet, to the best of our knowledge, there has been no comprehensive assessment of the quality of acoustically-patterned cell populations. In this report we use a mathematical approach, known as Voronoï tessellation, to generate a series of metrics that can be used to measure the effect of cell concentration, pressure amplitude, ultrasound frequency and biomaterial viscosity upon the quality of acoustically-patterned cell systems. Moreover, we extend this approach towards the characterization of spatiotemporal processes, namely, the acoustic patterning of cell suspensions and the migration of patterned, adherent cell clusters. This strategy is simple, unbiased and highly informative, and we anticipate that the methods described here will provide a systematic framework for all stages of acoustic patterning, including the robust quality control of devices, statistical comparison of patterning conditions, the quantitative exploration of parameter limits and the ability to track patterned tissue formation over time.
Dynamic Load Balancing of Software-Defined Networking Based on Genetic-Ant Colony Optimization

Load Balancing (LB) is one of the most important tasks required to maximize network performance, scalability and robustness. Nowadays, with the emergence of Software-Defined Networking (SDN), LB for SDN has become a very important issue. SDN decouples the control plane from the data forwarding plane to implement centralized control of the whole network. LB assigns the network traffic to the resources in such a way that no one resource is overloaded and therefore the overall performance is maximized. The Ant Colony Optimization (ACO) algorithm has been recognized to be effective for LB of SDN among several existing optimization algorithms. The convergence latency and searching optimal solution are the key criteria of ACO. In this paper, a novel dynamic LB scheme that integrates genetic algorithm (GA) with ACO for further enhancing the performance of SDN is proposed. It capitalizes the merit of fast global search of GA and efficient search of an optimal solution of ACO. Computer simulation results show that the proposed scheme substantially improves the Round Robin and ACO algorithm in terms of the rate of searching optimal path, round trip time, and packet loss rate.
When You Are Born Matters: The Imapct of Date of Birth on Child Cognitive Outcomes in England

The impact of date of birth on cognitive test scores is well documented across many countries, with the youngest children in each academic year performing more poorly, on average, than the older members of their cohort. However, relatively little is known about the driving forces behind these differences, at least in England; nor does there appear to have been a robust discussion regarding what, if anything, should be done in light of these disparities. We address both of these issues in this report.
On reading Chinese characters : a neuropsychological and experimental study

The research reported here attempts to identify those reading processes common to both alphabetic readers and readers of Chinese logographic characters, and those processes unique to Chinese reading. Three types of evidence are presented: (1) experimental studies of normal Chinese readers; (2) clinical and experimental investigations of Chinese patients with acquired dyslexic symptoms; (3) a survey of developmental dyslexia in China. Like alphabetic readers, Chinese readers show independent procedures for mapping from orthography to meaning and from orthography to sound. Also like alphabetic readers, the mapping to sound can be accomplished by both a lexical and a sublexical procedure. The special characteristics of Chinese script are analysed and their significance in reading processes are revealed. The research is presented in six chapters. Chapter 1 is the background of this study which contains a general review of reading studies of Chinese and other scripts, the main theoretical issues and the objectives of this study. Chapter 2 presents a new analysis of statistical properties of Chinese characters including the consistency of phonetic radicals. Chapter 3 presents experiments on reading Chinese characters by normal Chinese readers. In these studies, phonological recoding is demonstrated; the lateralization of reading Chinese characters is investigated; and finally, the errors of normal subjects' reading is examined. Chapter 4 contains a clinical study on Chinese acquired dyslexic patients. In this study, several Chinese acquired dyslexic symptoms are reported for the first time. Analogues of surface and deep dyslexia in Chinese patients are described for the first time. This supports the idea of independent lexical and sublexical procedures for mapping from orthography to sound. However, Chinese surface and deep dyslexia show features distinct from their alphabetic counterparts. In addition, it is also revealed that there are some special dyslexic symptoms which are predictable from the characteristics of Chinese script which I term associative dyslexia and compound dyslexia. Chapter 5 contains a survey on developmental dyslexia among 8106 Chinese pupils in which the ratio of developmental dyslexia is found to be lower (1.92%) than in alphabetic children. Chapter 6 presents the theoretical implications of the studies taken together for Chinese reading and for reading generally.
Provision Point-Source Materials Stimulates Play in Sows but Does Not Affect Aggression at Regrouping

Simple Summary In most intensive pig production systems, pigs are often mixed into new groups. Sows are important to a production system, as they are the driver behind the farms’ productivity. The aggression that results from sows being mixed into new groups and formation of hierarchy can detrimentally affect production and welfare. This study aimed to determine the effect of providing access to materials on aggressive and play behaviors in gestating sows. Play behaviors were observed in the ‘enhanced’ pen and no play was observed in standard housing (without materials present). Aggression measures, salivary free cortisol concentrations, and injury counts were unaffected by treatment. The provision of point-source materials to sows at mixing had no impact on aggression; however, their presence maintained sow interest over the course of the experiment. Additionally, play behavior was observed in their presence, which may suggest that a more positive affect was induced when the materials were provided. Abstract When sows are mixed into groups, hierarchies form and resulting aggression and stress can affect production and welfare. This study determined the effect of providing point-source materials on aggressive and play behaviors in gestating sows. Large white cross Landrace sows were mixed after insemination; six pens of 12 sows were housed in ‘standard’ pens, and six pens of 12 sows were housed in ‘enhanced’ pens. The ‘enhanced’ pens each contained two rubber mats, eight strands of 24 mm-thick sisal rope and two yellow plastic disks, suspended from the roof. The sows remained in these pens until pregnancy confirmation. Salivary cortisol concentration, injury counts, and sow behaviors were recorded the day before mixing (day 1), mixing (day 0) and post-mixing day 1, day 4, day 7 and day 20. At farrowing, reproductive outcomes were obtained. Play was observed (including locomotor and object play) in the ‘enhanced’ pen, and percentage of time spent playing was greater on d4 (1.48 ± 0.3 Square root transformed data (2.84% non-transformed adjusted mean)), d7 (1.43 ± 0.3 (2.97%)) and d20 (1.64 ± 0.3 (3.84%)), compared to d0 (0.56 ± 0.3 (0.70%)) and d1 (0.87 ± 0.3 (1.67%) (p < 0.05)). No play was observed in standard housing. Aggression, salivary free cortisol concentrations and injuries were unaffected (p > 0.05). The provision of materials had no impact on aggression, although their presence maintained sow interest and play behavior, suggesting a positive effect.
Changes in Both Neuron Intrinsic Properties and Neurotransmission Are Needed to Drive the Increase in GnRH Neuron Firing Rate during Estradiol-Positive Feedback

Central output of gonadotropin-releasing hormone (GnRH) neurons controls fertility and is sculpted by sex-steroid feedback. A switch of estradiol action from negative to positive feedback initiates a surge of GnRH release, culminating in ovulation. In ovariectomized mice bearing constant-release estradiol implants (OVX+E), GnRH neuron firing is suppressed in the morning (AM) by negative feedback and activated in the afternoon (PM) by positive feedback; no time-of-day-dependent changes occur in OVX mice. In this daily surge model, GnRH neuron intrinsic properties are shifted to favor increased firing during positive feedback. It is unclear whether this shift and the observed concomitant increase in GABAergic transmission, which typically excites GnRH neurons, are independently sufficient for increasing GnRH neuron firing rate during positive feedback or whether both are needed. To test this, we used dynamic clamp to inject selected previously recorded trains of GABAergic postsynaptic conductances (PSgs) collected during the different feedback states of the daily surge model into GnRH neurons from OVX, OVX+E AM, and OVX+E PM mice. PSg trains mimicking positive feedback initiated more action potentials in cells from OVX+E PM mice than negative feedback or OVX (open feedback loop) trains in all three animal models, but the positive-feedback train was most effective when applied to cells during positive feedback. In silico studies of model GnRH neurons in which >1000 PSg trains were tested exhibited the same results. These observations support the hypothesis that GnRH neurons integrate fast-synaptic and intrinsic changes to increase firing rates during positive feedback. SIGNIFICANCE STATEMENT Infertility affects 15%–20% of couples; failure to ovulate is a common cause. Understanding how the brain controls ovulation is critical for new developments in both infertility treatment and contraception. Ovarian estradiol alters both the intrinsic properties of gonadotropin-releasing hormone (GnRH) neurons and synaptic inputs to these cells coincident with production of sustained GnRH release that ultimately triggers ovulation. We demonstrate here using dynamic clamp and mathematical modeling that estradiol-induced shifts in synaptic transmission alone can increase firing output, but that the intrinsic properties of GnRH neurons during positive feedback further poise these cells for increased response to higher frequency synaptic transmission. These data suggest that GnRH neurons integrate fast-synaptic and intrinsic changes to increase firing rates during the preovulatory GnRH surge.
The role of carbapenem-resistant pathogens in cSSTI and how to manage them

Purpose of review Skin and soft tissue infections (SSTIs) with a wide spectrum of disease severity ranging from uncomplicated to potentially lethal are still a leading cause of morbidity and mortality. The burden of carbapenem-resistant gram-negative bacteria (CR-GNB) in SSTIs is increasing. Luckily, the armamentarium of drugs available is recently expanding as well. The present review looks at data on the role CR-GNB in SSTIs and on the old and new drugs available for the treatment of carbapenem-resistant Enterobacteriaceae (CRE), Pseudomonas, and Acinetobacter. Recent findings The most recent information concern the availability of new antibiotics that, even if no specific clinical trials on complicated SSTIs (cSSTIs) have been performed, may play a role in clinical practice also for the treatment of cSSTIs caused by CR-GNB. Ceftolozane-tazobactam has been found to be a good option for CR Pseudomonas infections including SSTIs. Ceftazidime-avibactam is approved for several indications, including aerobic GNB infections with limited treatment options. Meropenem–vaborbactam therapy has been associated with decreased mortality in infections caused by CRE. Eravacycline has the potential to become useful for the treatment of CR Acinetobacter for which the treatment options are limited. Summary In the carbapenem resistance era, the physicians goal should be to stratify patients according to risk factors for CR-GNB causing SSTIs in order to minimize inappropriate initial therapies. Some recently approved drugs seem destined to become the backbone of target therapy in patients with severe infections caused by susceptible CR-GNB strains. Prompt diagnosis of cSSTIs is crucial and, when feasible, surgical debridement as source control is essential as well.