Miracle-dz/UniFAR-FTUs huggingface dataset:
Búsquedas de respuestas con Deep Learning

Esta memoria explica, en primer lugar, como funcionan sistemas de pregunta y respuesta existentes en la actualidad. En concreto, se estudian diversos sistemas relacionados con la medicina, debido que en un primer momento, en este trabajo se pretendia implementar un chat medico. A partir de conocer como funcionan los sistemas existentes y tener claro lo que se quiere conseguir, se sigue explicando los fundamentos tecnico-teoricos mas importantes del Deep Learning de cara a la implementacion final del sistema de preguntas y respuestas. En concreto se hace mucho enfasis en los fundamentos del Machine Learning, los tipos diferentes de Redes Neuronales Recurrentes y como usarlas, y la arquitectura Encoder-Decoder. En el siguiente capitulo se explica la teoria del procesamiento del lenguaje natural. Este apartado de la memoria se explica en conjunto con Spacy, para darle tambien un enfoque mas practico. Al finalizar se explican los diferentes metodos de representacion del lenguaje en vectores numericos. Despues empezara la segunda parte, y la mas importante del TFG, que es como se han aplicado estos conceptos teoricos al sistema de preguntas y respuestas final. Se empieza por explicar lo que hace el codigo de manera secuencial y muy abstracta evadiendose en todo momento del codigo en si, para ahondar en por que funciona de una forma mas conceptual y teorica. A continuacion, se hace mencion a cada uno de los experimentos a los que se sometio el sistema y se comentan los resultados. Finalmente se procede a dar una opinion personal de por que se han obtenido tales resultados y las soluciones que se le darian, haciendo hincapie en que se tienen que demostrar todos de manera empirica.
A Butterfly Substrate Integrated Waveguide Leaky-Wave Antenna

A new leaky-wave antenna taking advantage of substrate integrated waveguide technology has been introduced. This antenna has a butterfly-like configuration consisting of eight wings, i.e., eight parts. By this configuration, better gain and side-lobe level for lower elevation angles (12 °-45 °) are obtained while in the uniform design, these angles were scanned with poor radiation performances. Besides, an effective matching part for good impedance matching has been employed. The simulated data have been compared with measurement results and showed good consistency.
Cross Lingual Opinion Analysis via Transfer Learning

This paper presents the first attempt to apply instance-level transfer learning technique to cross lingual opinion analysis by using the translation of annotated corpus from other languages as the supplementary training data for the opinion classifier for target language. Firstly, Transfer AdaBoost algorithm (TrAdaBoost) is applied as the base transfer learning strategy, which makes use of few labeled examples in target language to leverage the large annotated corpus in other languages and selects the translated annotated data with good confidence as supplementary training samples to improve the opinion classifier for target language. Considering that the re-weighting scheme adopted in TrAdaBoost has the potential risk of over-discarding of source training examples, this algorithm is further improved by combining the bagging procedure and the boosting procedure of TrAdaBoost, named Transfer Boosting with Bagging (TrBB). The proposed two algorithms are evaluated on document-level and sentence-level Chinese opinion analysis, respectively. The achieved encouraging performances show that the proposed transfer learning based approaches improve the opinion analysis effectively by exploiting small training data in target language and large cross lingual training data.
Involvement of the Posteroventral Caudate-Putamen in Memory Consolidation in the Morris Water Maze

Male Sprague-Dawley rats implanted with bilateral intracerebral guide cannulae were trained in the standard hidden platform version of the Morris water maze and given immediate posttraining infusions of the D2 dopamine receptor antagonist sulpiride (10.0 or 100.0 ng/side) or saline vehicle into the posteroventral caudate-putamen. Retention was tested 2 days later with a probe trial. Sulpiride-treated rats spent less time swimming near the trained platform location and more time in the periphery of the maze than controls, although their latency to reach the trained platform location was not significantly affected. The pattern of results suggests that whereas the posteroventral caudate-putamen seems to be involved in consolidation of memory in the Morris water maze, it may be involved in memory for procedural aspects of the task in a manner distinct from that of other brain regions such as the hippocampus.
The Formation of Population III Binaries from Cosmological Initial Conditions

Genesis of Binary Stars Numerical simulations of collapsing clouds of primordial gas indicate that the first luminous objects to form in the universe were isolated massive stars. Turk et al. (p. 601, published online 9 July) now show that it is possible for single primordial clouds to break up into two dense cores. Three-dimensional calculations, which follow the evolution of primordial gas (composed of hydrogen and helium, with traces of deuterium and lithium) and dark matter starting from realistic, cosmological initial conditions, suggest that these cores may evolve to form binary star systems. Simulations show that binary systems are likely to exist among the first generation of stars. Previous high-resolution cosmological simulations predicted that the first stars to appear in the early universe were very massive and formed in isolation. Here, we discuss a cosmological simulation in which the central 50 M⊙ (where M⊙ is the mass of the Sun) clump breaks up into two cores having a mass ratio of two to one, with one fragment collapsing to densities of 10−8 grams per cubic centimeter. The second fragment, at a distance of ~800 astronomical units, is also optically thick to its own cooling radiation from molecular hydrogen lines but is still able to cool via collision-induced emission. The two dense peaks will continue to accrete from the surrounding cold gas reservoir over a period of ~105 years and will likely form a binary star system.
Drives Comparison for Reciprocating and Renewable Energy Applications

The objective of this work is to compare and analyze brushed dc, induction, brushless dc, and synchronous reluctance machines and drives in reciprocating applications. In particular, this work is focused on wave energy generator applications. In contrast to wind energy, the ocean environment can require bidirectional operation of the generator. For this study, the efficiency of a set of small induction, permanent magnet synchronous, brushed dc, and synchronous reluctance drives and machines were compared side-by-side in a reciprocating application against the typical constant operation used to determine steady state efficiency. The presented results suggest that drives and machines used in ocean wave energy should not expect a large de-rating in nameplate machine or drive efficiency compared to the same drive or machine producing the same amount of power constantly. In addition, it is shown that the frequency of reciprocation (e.g., ocean wave frequency) has little impact on efficiency.
Regulation of drug‐metabolizing enzymes during the perinatal period in rat and human liver

The importance of drug‐metabolizing enzymes in developing mammals has been recently reevaluated in view of the activities and potential inducibilities of these enzymes. The role of endogenous factors raises the question of whether there is a positive regulation of the expression of drug‐metabolizing enzymes by hormones. In humans, among the different isoenzymes of cytochrome P‐450 described in adult liver, only one is absent in 20‐week‐old fetuses. Epoxide hydrolase and glutathione S‐transferases are active while UDP‐glucuronidation develops postnatally. The consequence of this asynchronous rise of activities is briefly discussed.
Analysis of the relationship between luminescence and toxicity of Vibrio carchariae pathogenic to shrimp

Aquaculture deterioration is caused by Vibrio harveyi, which is one of the main shrimp pathoges. Vibrio carchariae having the same phenotypic characteristics as V. harveyi was isolated from a shrimp farm and used in this study to investigate the relationship between luminescence and toxicity. Luminescence was verified by monitoring the expression of the LuxR gene. It was found that the relationship between the expression of LuxR and toxicity was the most significant factor related to luminescence. Results showed that LuxR expression was highest after 20 h of culture, which is comparable to the highest scintillation counter luminescence value (20 h). However, toxin levels in the culture broth were highest between 24 h-36 h of culture. Significant decrease in the toxicity level was observed after 36 h. It was also found that there was a decrease in toxicity level after 12 h of incubation at room temperature of the V. carchariae culture supernatant. The effect of the addition of cell-free culture supernatant on the luminescence of V. carchariae was also determined. Results showed that the addition of cell-free supernatant from 24 h-old culture was most effective in inducing and maintaining luminescence.
Pharmacogenetics and pharmacogenomics as tools in cancer therapy

Abstract Pharmacogenetics and pharmacogenomics (PGx) are rapidly growing fields that aim to elucidate the genetic basis for the interindividual differences in drug response. PGx approaches have been applied to many anticancer drugs in an effort to identify relevant inherited or acquired genetic variations that may predict patient response to chemotherapy and targeted therapies. In this article, we discuss the advances in the field of cancer pharmacogenetics and pharmacogenomics, driven by the recent technological advances and new revolutionary massive sequencing technologies and their application to elucidate the genetic bases for interindividual drug response and the development of biomarkers able to personalize drug treatments. Specifically, we present recent progress in breast cancer molecular classifiers, cell-free circulating DNA as a prognostic and predictive biomarker in cancer, patient-derived tumor xenograft models, chronic lymphocytic leukemia genomic landscape, and current pharmacogenetic advances in colorectal cancer. This review is based on the lectures presented by the speakers of the symposium “Pharmacogenetics and Pharmacogenomics as Tools in Cancer Therapy” from the VII Conference of the Spanish Pharmacogenetics and Pharmacogenomics Society (SEFF), held in Madrid (Spain) on April 21, 2015.
Reciclagem de cavacos de ligas de alumínio 7050-T7451 utilizando conformação por spray e tratamentos termomecânicos

O objetivo deste trabalho e avaliar a conjugacao de tecnicas conhecidas de processamento para a definicao de uma rota de reciclagem de cavacos de usinagem. Estes sao gerados durante a manufatura de pecas primarias a partir de placas da liga de aluminio 7050-T7451, adquiridas conforme AMS 4050H. Os principais processos utilizados nesta rota de reciclagem dos cavacos foram: refusao por conformacao por spray, processamentos termomecânicos e tratamentos termicos. O tratamento termico de homogeneizacao antes da extrusao e a solubilizacao antes do envelhecimento melhorou significativamente a resposta do material ao tratamento termico. A utilizacao do ensaio de torcao a quente foi fundamental para definir a melhor condicao de processamento para a obtencao de uma microestrutura refinada. Juntamente com os ensaios de torcao a quente, uma metodologia de tratamento e analise dos dados de torcao a quente foi desenvolvida. Baseado nos dados obtidos, uma nova matriz de extrusao foi projetada. O tamanho medio de grao de 4,0 m que foi obtido apresentou boa correlacao com as analises do ensaio de torcao a quente, para condicoes semelhantes de processamento. Os resultados obtidos durante a realizacao dos ensaios mecânicos de tracao apresentaram resultados superiores aos especificados na AMS 4050 H. Da mesma forma, os dados preliminares de fadiga do material, mostraram que os dados obtidos estao na mesma nuvem de dispersao dos dados do MMPDS-06 (antigo MIL-HDBK-5), para condicoes semelhantes de ensaios, e atende aos criterios de fadiga da AMS 4050 H.
Identity of the Residues Responsible for the Species-restricted Complement Inhibitory Function of Human CD59*

The membrane-anchored glycoprotein CD59 inhibits assembly of the C5b-9 membrane attack complex (MAC) of human complement. This inhibitory function of CD59 is markedly selective for MAC assembled from human complement components C8 and C9, and CD59 shows little inhibitory function toward MAC assembled from rabbit and many other non-primate species. We have used this species selectivity of CD59 to identify the residues regulating its complement inhibitory function: cDNA of rabbit CD59 was cloned and used to express human/rabbit CD59 chimeras in murine SV-T2 cells. Plasma membrane expression of each CD59 chimera was quantified by use of a 5′-TAG peptide epitope, and each construct was tested for its ability to inhibit assembly of functional MAC from human versus rabbit C8 and C9. These experiments revealed that the species selectivity of CD59 is entirely determined by sequence contained between residues 42 and 58 of the human CD59 polypeptide, whereas chimeric substitution outside this peptide segment has little effect on the MAC inhibitory function of CD59. Substitution of human CD59 residues 42–58 into rabbit CD59 resulted in a molecule that was functionally indistinguishable from native human CD59, whereas the complementary construct (corresponding residues of rabbit CD59 substituted into human CD59) was functionally indistinguishable from rabbit CD59. Based on the solved solution structure of CD59, these data suggest that selectivity for human C8 and C9 resides in a cluster of closely spaced side chains on the surface of CD59 contributed by His44, Asn48, Asp49, Thr51, Thr52, Arg55, and Glu58 of the polypeptide.
A Novel Robust Negative High Gain ILC Current Controller for PMSM

This paper presents the novel robust negative high gain Iterative Learning current controller for PMSM. The conventional Iterative learning current controller is simulated and proof read. High gain controller is designed and PI controller is replaced with High gain controller. Negative gain is introduced in the high gain controller. Due to inverting operation of the controller, the stability can be improved. The improved performance is simulated using MATLAB/SIMULINK and it is presented.
Transfer of experimental autoimmune thyroiditis of the mouse by serum.

The problem of the participation of cellular and humoral factors in the pathogenesis of experimental autoimmune diseases has been discussed for more than two decades without arriving at a definite conclusion. The lack of correlation between the intensity of tissue damage and titer of humoral antibodies (1, 2) in the fact of the existence of such a correlation with delayed skin reactions (3) suggested that autoimmune damage is a delayed type of hypersensitivity. Thereafter, the successful transfer of autoimmune disease by lymphoid cells (4, 5) and the failure of transfer by serum (1,6) enforced the belief that circulating antibodies do not play a causative role in the pathogenesis of autoimmune diseases. However, in recent years, successful serum transfers of autoimmune diseases have been reported. In these experiments rather special procedures were used for inducing the tissue damage: injection of the serum into the target organ (7, 8), the removal of the target organ from donors (9), x-irradiation of donors (10) or recipients (11), and pretreatment of recipients with Freund's adjuvant or 131I (11).
Sp1/Sp3 compound heterozygous mice are not viable: Impaired erythropoiesis and severe placental defects

The ubiquitously expressed zinc finger transcription factors Sp1 and Sp3 play critical roles in embryonic development. Sp1 knockout mice die around embryonic day 10.5. Mice lacking Sp3 are postnatal lethal. Mice heterozygous for either Sp1 or Sp3 are apparently normal, although slightly smaller. Here, we show that compound heterozygosity of Sp1 and Sp3 results in embryonic lethality accompanied by a spectrum of developmental abnormalities, including growth retardation, morphological alterations of the lung, impaired ossification, anemia, and placental defects. Anemia in Sp1/Sp3 compound heterozygous mutant embryos is associated with impaired maturation of erythrocytes. Analyses of the placenta revealed a markedly reduced spongiotrophoblast layer and a severe disorganization of the labyrinth layer in Sp1/Sp3 compound heterozygous as well as in Sp3‐deficient mutant embryos. Our findings demonstrate that a threshold of Sp1 and Sp3 activity is required for normal embryonic development, suggesting that Sp1 and Sp3 act cooperatively to regulate downstream targets. Developmental Dynamics 236:2235–2244, 2007. © 2007 Wiley‐Liss, Inc.
Histopathological Study of Ovarian Lesions

Introduction: Ovarian lesions manifest with a wide spectrum of clinical, morphological and histological features. The complex nature, unpredictable behavior, prognosis and controversial management make ovarian lesions a difficult problem for gynecologist hence this study was undertaken with following aims & objectives. Objectives: This study is undertaken to characterize the ovarian lesions based on histopathological features and to find out the frequency of benign and malignant neoplasms with their clinicopathological correlation. Results: Of the 485 cases of ovarian lesions studied, 109 cases were benign, 17 cases were malignant & 3 were borderline lesions. The tumors can occur at any age. The most common symptom was abdominal pain. Commonest benign epithelial tumors were Serous cystadenoma (55.4%). Among primary malignant tumors clear cell carcinoma(2-3%) was most common. Conclusion: The ovary is a frequent site for primary and metastatic tumors. Due to its complex structure, primary ovarian neoplasms are of diverse histological types. Certain neoplastic lesions of the ovary frequently form a pelvic mass and potentially mimic on ovarian neoplasm. Their proper recognition is therefore important to allow appropriate therapy.
Understanding and improving high-throughput sequencing data production and analysis

New high-throughput sequencing technologies make it possible to apply sequence-based approaches in an unanticipated number of fields. In the field of evolutionary genetics, it is now feasible to apply sequencing-based approaches for a wide range of comparative genomic studies. For example, high-throughput sequencing can be applied to study the genomes from ancient specimens of different hominin groups, like Neandertals and Denisovans, and allow large-scale population genetics studies of present-day humans as well as measuring quantitative differences in the transcriptomes and DNA-interactome of different apes and primates.
The Bipartite Influence of Information Overload on User Resistance to Knowledge Management Systems

This research centers on the relationship between information overload as an aspect of information quality on the one side, and, on the other side, user resistance to knowledge management systems as an aspect of an individual's decision process. While discussing this relationship theoretically we propose a bipartite influence of information overload as on the one hand it fosters acceptance of these system, but on the other hand also causes user resistance. By analyzing information overload in pre- and post-implementation phases of knowledge management systems we argue that information overload has an ambivalent causal effect as it can act both positively and negatively in relation to the point of time overload occurs or is expected. Therefore, based on existing literature we propose a research model and illustrate the relationships through results of a case study.
Automatic labeling of prosodic patterns

This paper describes a general algorithm for labeling prosodic patterns in speech, which provides a mechanism for mapping sequences of observations (vectors of acoustic correlates) to prosodic labels using decision trees and a Markov sequence model. Important and novel features of the approach are that it allows many dissimilar correlates to be treated in a unified manner to provide more robust labeling, and that it is designed to be a post-word-recognition processing step. Application of the algorithm is illustrated with experimental results for labeling prosodic phrasing and phrasal prominence in two corpora of professionally read speech. The labels produced by the automatic algorithm exhibit agreement with hand-labeled prominence and phrasing that is close to the agreement between different human labelers. >
CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism.

CD36, identified more than a quarter of a century ago as a platelet integral membrane glycoprotein (glycoprotein IV), was until recently best known as a receptor for thrombospondin-1 (TSP-1). TSP-1 is found in ECMs and platelet α granules, and it participates in cell attachment, motility, and proliferation, as well as in modulation of protease activity, TGF-β activation, neurite outgrowth, and angiogenesis (1). Initially, this receptor-ligand pair was shown to mediate interactions between platelets and monocytes, tumor cells, and matrix. Since then, CD36 has been implicated in multiple biological processes that define it as a multiligand scavenger receptor (see ref. 2 for review). These ligands appear remarkably diverse: In addition to TSP-1, they include long-chain fatty acids, modified LDL, retinal photoreceptor outer segments, Plasmodium falciparum malaria-parasitized erythrocytes, sickle erythrocytes, anionic phospholipids, apoptotic cells, and collagens I and IV. The biology of CD36 can be broadly divided in terms of functions that it mediates with or without TSP-1, but it is probable that it acts in concert with other proteins, such as fatty acid–binding proteins, caveola-associated proteins, integrins, cytoskeletal proteins, and signaling molecules, to effect its diverse functions.
Microstrip and Coplanar Band-Pass Filters Using MMIC Negative Resistance Circuits For Insertion Losses Compensation And Size Reduction

A new band-pass filter design technique is presented which uses classical passive interdigitated filters assisted by a MMIC active component circuit. The MMIC component performs a negative resistance with an associated imaginary part. By using this component, the negative resistance leads to compensate for the losses of the passive filter while the imaginary part leads to reduce significantly the length of the resonator. Two filters, implemented in microstrip and coplanar technologies have been designed and tested to demonstrate our approach.