Miracle-dz/UniFAR-FTUs huggingface dataset:
Karakteristik, Dukungan Keluarga dan Efikasi Diri pada Lanjut Usia Diabetes Mellitus Tipe 2 di Kelurahan Padangsari, Semarang

Pendahuluan: Dukungan keluarga pada lansia DM tipe 2 sangat penting dalam manajemen diabetes, dimana anggota keluarga terlibat dalam banyak aspek kegiatan perawatan kesehatan yang diperlukan pasien diabetes. Adanya dukungan keluarga yang besar dapat meningkatkan efikasi diri penderita. Keyakinan pada diri pasien DM dapat ditunjukkan dari sebuah perilaku tertentu dan mengubah pola pikir tertentu. Metode: Penelitian kuantitatif korelasional dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah seluruh lansia dengan DM tipe 2 di Kelurahan Padangsari sebanyak 104 orang. Tehnik sampling yang digunakan semua anggota populasi menjadi sampel. Pengumpulan data mennggunakan kuesioner karakteristik demografi responden, kuesioner dukungan keluarga, efikasi diri. Analisis data dilakukan dengan menggunakan uji Pearson product moment danregresi linier. Hasil: Hubungan dukungan keluarga dengan efikasi diri lansia DM tipe 2 dengan (p value 0.008) dengan nilai r=0.258, tidak ada hubungan antara karakteristik responden dengan efikasi diri, kecuali jenis kelamin. Faktor yang paling berkontribusi pada efikasi diri lansia DM tipe 2 adalah jenis kelamin dengan nilai (p value=0.023; B=2.235). Pembahasan: Lansia mampu mengelola DM tipe 2 dengan baik bila ada peningkatan efikasi diri untuk menerima kondisinya disertai dengan dukungan keluarga yang baik. Kesimpulan: Meningkatkan efikasi diri pada lansia DM tipe 2 dengan memberikan pendidikan kesehatan, dan memfasilitasi dukungan sosial.
Cognitive diversity among upper‐echelon executives: implications for strategic decision processes

Diversity among executives is widely assumed to influence a firm's strategic decision processes, but empirical research on this linkage has been virtually nonexistent. To partially fill the void, we drew upon three separate studies to examine the impact of executive diversity on comprehensiveness of strategic decision-making and extensiveness of strategic planning. Contrary to common assumptions of researchers and executives, our results suggest that executive diversity inhibits rather than promotes comprehensive examinations of current opportunities and threats, and inhibits rather than promotes extensive long-range planning. In light of the cumulative research showing that firm performance is related to both comprehensiveness and extensiveness, our results provide evidence for an indirect connection between executive diversity and firm performance. 1998 John Wiley & Sons, Ltd.
Multidrug resistant proteins: P-glycoprotein and lung resistance protein expression in retinoblastoma

Background/aim: Retinoblastoma is the commonest primary intraocular tumour in children. Chemotherapy now plays a big part in the treatment of these tumours. There is not much information about the role of the multidrug resistance proteins (MDR)—P-glycoprotein (P-gp) and vault protein lung resistance protein (LRP)—in retinoblastoma. The authors investigated the expression of P-gp and LRP in retinoblastoma and correlated them clinicopathologically. Methods: Among 60 retinoblastomas, 40 tumours were not subjected to preoperative or postoperative chemotherapy and 20 tumours were subjected to postoperative chemotherapy. In this cohort 27 tumours had no invasion and 33 tumours had invasion of choroid, optic nerve, and orbit. P-gp and LRP expression were studied by immunohistochemistry. Immunoanalysis was done semiquantitatively. Results: Among the 60 tumours P-gp was expressed in 23 (38%) tumours and LRP was expressed in 35 (58%). P-gp was expressed in 11/27 (40%) tumours with no invasion and in 12/33 (36%) tumours with invasion. LRP was expressed in 15/27 (55%) tumours with no invasion and in 20/33 (60%) tumours with invasion. Both P-gp and LRP were negative in three tumours with invasion, which had later developed bone marrow metastasis. There was no correlation between P-gp and LRP expression with invasion, differentiation and laterality of the tumours and response to treatment. Conclusion: Retinoblastoma expresses P-gp and LRP intrinsically before chemotherapy and none of these proteins predicted the response to chemotherapy. Thus, further studies are needed to understand the significance of the expression of the P-gp and LRP proteins in retinoblastoma.
Too far to walk: maternal mortality in context.

This article briefly capsules some of the thinking about obstacles obstetrics patients encounter on the way to a care facility, which is based on over 200 research studies or articles. The bibliography is available on request and not included in the article. Delay in seeking care is presented in 3 ways. The 1st is in the decision to seek care and discussion is presented in Newsletter 35. The 2nd delay is in reaching a facility after the decision is made, which is the subject of this article. The 3rd delay is in receiving the needed care and will appear in Newsletter 37. Based on interviews of rural Kenyan women, of the 47% intending to deliver in a hospital, only 36% actually did so. Distance and unavailability of public transportation in other studies were expressed as obstacles that prevented women from reaching the hospital. There is not systematic documentation in the literature of these types of delays. Consequently, programs which identify high risk women for hospital delivery and raising community awareness may be ineffective if there is inaccessibility of the facility. Urban areas have better access to health facilities, and there is uneven distribution in rural areas even in developed countries such as Portugal. The example of an equitably distributed health network exists in Cuba. The implications of the shortage of health facilities and health care providers and the uneven distribution are that limited access interferes with usage. The nature of the terrain and the condition of the roads and the actual distances are considerations. Many inhabitants must walk or improvise a means of transportation to reach health care, because there is a scarcity of public transportation. The patients condition may deteriorate on the way which makes treatment more difficult, provided the patient is still alive upon arrival. An example is given of a Tanzanian women bleeding to death waiting for a taxi. A decision to seek care may be timely, but impaired access prevented utilization. An additional complication is a situation where the nearest facility is not equipped to treat the condition or even administer essential first aid. A further delay occurs in transporting the patient to the proper facility. Death enroute data is scarce, and may be included in home deaths, but maternal mortality study data is available.
Sequential Release of GABA by Exocytosis and Reversed Uptake Leads to Neuronal Swelling in Simulated Ischemia of Hippocampal Slices

GABA release during cerebral energy deprivation (produced by anoxia or ischemia) has been suggested either to be neuroprotective, because GABA will hyperpolarize neurons and reduce release of excitotoxic glutamate, or to be neurotoxic, because activation of GABAA receptors facilitates Cl– entry into neurons and consequent cell swelling. We have used the GABAA receptors of hippocampal area CA1 pyramidal cells to sense the rise of [GABA]o occurring in simulated ischemia. Ischemia evoked, after several minutes, a large depolarization to ∼–20 mV. Before this “anoxic depolarization,” there was an increase in GABA release by exocytosis (spontaneous IPSCs). After the anoxic depolarization, there was a much larger, sustained release of GABA that was not affected by blocking action potentials, vesicular release, or the glial GABA transporter GAT-3 but was inhibited by blocking the neuronal GABA transporter GAT-1. Blocking GABAA receptors resulted in a more positive anoxic depolarization but decreased cell swelling at the time of the anoxic depolarization. The influence of GABAA receptors diminished in prolonged ischemia because glutamate release evoked by the anoxic depolarization inhibited GABAA receptor function by causing calcium entry through NMDA receptors. These data show that ischemia releases GABA initially by exocytosis and then by reversal of GAT-1 transporters and that the resulting Cl– influx through GABAA receptor channels causes potentially neurotoxic cell swelling.
Deregulation of microRNA expression in human thyroid carcinomas

Carcinoma of the thyroid gland is an uncommon cancer, but one of the most frequent malignancies of the endocrine system. Most thyroid cancers are derived from the follicular cells. Follicular carcinoma is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one of the most lethal human cancers. Even though several genetic lesions have been already described in human thyroid cancer, particularly in the papillary histotype, the mechanisms underlying the development of these neoplasias are still far from being completely elucidated. Some years ago, several studies were undertaken to analyze the expression of microRNAs (miRNAs or miRs) in thyroid carcinoma to evaluate a possible role of their deregulation in the process of carcinogenesis. These studies showed an aberrant microRNA expression profile that distinguishes unequivocally among PTC, ATC, and normal thyroid tissue. Here, other than summarizing the current findings on microRNA expression in human thyroid carcinomas, we discuss the mechanisms by which microRNA deregulation may play a role in thyroid carcinogenesis, and the possible use of microRNA knowledge in the diagnosis and therapy of thyroid neoplasms. Endocrine-Related Cancer (2010) 17 F91–F104
Occupied and abandoned structures from ecosystem engineering differentially facilitate stream community colonization

Ecosystem engineers transform habitats in ways that facilitate a diversity of species; however, few investigations have isolated short‐term effects of engineers from the longer‐term legacy effects of their engineered structures. We investigated how initial presence of net‐spinning caddisflies (Hydropsychidae) and their structures that provide and modify habitat differentially influence benthic community colonization in a headwater stream by conducting an in situ experiment that included three treatments: (1) initial engineering organism with its habitat modification structure occupied (hereafter caddisfly); (2) initial habitat modification structure alone (hereafter silk); and (3) a control with the initial absence of both engineer and habitat modification structure (hereafter control). Total invertebrate colonization density and biomass was higher in caddisfly and silk treatments compared to controls (~25% and 35%, respectively). However, finer‐scale patterns of taxonomy revealed that density for one of the taxa, Chironomidae, was ~19% higher in caddisfly compared to silk treatments. Additionally, conspecific biomass was higher by an average of 50% in silk treatments compared to controls; however, no differences in Hydropsyche sp. biomass were detected between caddisfly treatments and controls, indicating initially abandoned silk structures elevated conspecific biomass. These findings suggest that the positive effects of the habitat modification structures that were occupied for the entirety of the experiment may outweigh any potential negative impacts from the engineer, which is known to be territorial. Importantly, these results reveal that the initial presence of the engineer itself may be important in maintaining the ecological significance of habitat modifications. Furthermore, the habitat modifications that were initially abandoned (silk) had similar positive effects on conspecific biomass compared to caddisfly treatments, suggesting legacy effects of these engineering structures may have pertinent intraspecific feedbacks of the same magnitude to that of occupied habitat modifications. Elucidating how engineers and their habitat modifications differentially facilitate organisms will allow for a clearer mechanistic understanding of the extent to which animal engineers and their actions influence aspects of community organization such as colonization.
Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

BACKGROUND Platelet-rich plasma (PRP) was identified as having a beneficial effect in alopecia and has been postulated as a new therapy for androgenetic alopecia (AGA). OBJECTIVE To assess the efficacy of PRP for the treatment of AGA. MATERIALS AND METHODS This was a randomized, placebo-controlled, double-blind study in 25 patients with AGA. Platelet-rich plasma was injected in half-head and the other half-head with placebo. Each patient received a total of 3 treatments of PRP, 1 month apart. RESULTS Six months after the first treatment with PRP, significant differences were seen in mean anagen hairs (67.6 ± 13.1), telogen hairs (32.4 ± 13.1), hair density (179.9 ± 62.7), and terminal hair density (165.8 ± 56.8) when compared with baseline (p < .05). Platelet-rich plasma was also found to increase hair density when comparing with the control side (p < .05). For the first time, the authors found a correlation between anagen hairs and patients >40 years and beginning of AGA ≥25 years old (p < .05) and hair density and male sex, age ⩽40 years, positive family history of AGA and >10 years of duration of the disease (p < 0.05). CONCLUSION Application of PRP showed a positive effect on AGA and could be regarded as an adjuvant therapy for AGA.
Detection of Sand and Dust Storms from MERIS Image Using FE-Otsu Alogrithm

Aiming at resolving the issue of Sand and Dust Storm (SDS) location in a remote sensing image, a new method is proposed in this paper to detect the center and intensity of a SDS automatically. First, SDS coverage area is extracted from remote sensing images by 2D-Otsu algorithm combined with fuzzy entropy, and the PSO algorithm is implemented to accelerate the process of global threshold selection. And then SDS intensity is evaluated according to the area ratio of SDS in an image. Based on implementation of morphological operations, major region of SDS is confirmed and the SDS center is detected using mass searching algorithm. Experimental result shows that the center and intensity of SDS can be detected rapidly and efficiently.
Gabapentin and Pregabalin Can Interact Synergistically with Naproxen to Produce Antihyperalgesia

Background Gabapentin and pregabalin are anticonvulsants with antihyperalgesic effects in animal models of neuropathic and inflammatory nociception. This study characterized the manner in which gabapentin or pregabalin interacts with naproxen to suppress thermal hyperalgesia and inflammation in the carrageenan model of peripheral inflammation. Methods Gabapentin, pregabalin, naproxen, or a fixed-dose ratio of gabapentin + naproxen or pregabalin + naproxen was administered orally to rats after the induction of inflammation by intraplantar injection of &lgr;-carrageenan in one hind paw. Nociceptive thresholds were determined by the radiant heat paw-withdrawal test. Paw edema was measured by plethysmometry. Drug plasma concentrations were determined by a liquid chromatography–mass spectroscopy–mass spectroscopy method. Results Gabapentin, pregabalin, and naproxen alone reversed thermal hyperalgesia with ED50 values of 19.2, 6.0, and 0.5 mg/kg, respectively. Mixtures of gabapentin + naproxen in fixed-dose ratios of 50:1, 10:1, or 1:1 interacted synergistically to reverse carrageenan-induced thermal hyperalgesia. However, 1:50 gabapentin + naproxen produced only additive effects. No combination of gabapentin + naproxen decreased paw edema in a manner greater than additive. Plasma concentrations of gabapentin and naproxen were unaltered by the addition of the other drug. The mixture of 10:1 of pregabalin + naproxen interacted synergistically to reverse thermal hyperalgesia on the inflamed hind paw, whereas mixtures of 1:1 or 1:10 produced additive effects. Conclusions These data suggest that gabapentin + naproxen and pregabalin + naproxen can interact synergistically or additively to reverse thermal hyperalgesia associated with peripheral inflammation. Therefore, the use of gabapentin or pregabalin in low-dose combinations with naproxen may afford therapeutic advantages for clinical treatment of persistent inflammatory pain.
Accelerating Matrix Multiplication in Deep Learning by Using Low-Rank Approximation

The open source frameworks of deep learning including TensorFlow, Caffe, Torch, etc. are widely used all over the world and its acceleration have great meaning. In these frameworks, a lot of computation time is spent on convolution, and highly tuned libraries such as cuDNN play important role on accelerating convolution. In these libraries, however, a convolution computation is performed without approximating a dense matrices. In this research, we propose a method to introduce the low-rank approximation method, widely used in the field of scientific and technical computation, into the convolution computation. As a result of investigating the influence on the recognition accuracy of the existing model, it is possible to reduce up to about 90% of rank of data matrices while keeping recognition accuracy −2% of baseline.
Influence of Six Vegetable Cultivars on Reproduction of Meloidogyne javanica.

Replicated field and greenhouse experiments were used to evaluate the effect of tomato, cabbage, cucumber, carrot, Amaranthus hybridus, and pepper on growth and fecundity of Meloidogyne spp. , particularly M. javanica. In the field tests, tomato, cucumber, and carrot favored population increases of Meloidogyne spp. , while Amaranthus, pepper, and cabbage limited them. Some cropping sequences that included crops from the latter group had a suppressive effect on population growth. Thus, of the 36 cropping sequences that were investigated, the following kept the pests in check: tomato-pepper; tomato-Amaranthus; cabbage-pepper; Amaranthus-pepper; carrot-cabbage; pepper-pepper; pepper-Amaranthus; and Amaranthus-pepper. In the greenhouse tests, tomato, cucumber, and carrot had a high number of galls per 50 cm of root, large, conspicuous galls and egg masses, and a high number of larvae per egg mass. Thus, they were highly susceptible. Cabbage and Amaranthus were unsuitable hosts as reflected in the absence of galls or a low number per 50 cm of root. small size of galls and egg masses, and few progeny on the subsequent crop of pepper. The length of time required for eggs to hatch on different hosts varied considerably and is thought to be a significant factor in infection of hosts.
An Unusual Cause of a High Carbonhydrate Antigen 19–9 Level in an Elderly Individual: Polycystic Liver Disease

teroids, intravenous immunoglobulin, and possibly plasmapheresis as first-line therapy, adding rituximab or cyclophosphamide as second-line therapies in refractory cases. A few people have shown spontaneous improvement without treatment. Despite broad cognitive dysfunction in the acute phase, as in the current case, individuals with VGKC LE can make substantial or full recovery with immunotherapy (75–80%), but it may take time. Finally, because LE may be reversible and treatable, it should be thought of when rapidly progressive cognitive disorder is associated with epileptic seizure, as can be seen in Creutzfeldt-Jakob disease, the main differential diagnostic.
Membrane raft microdomains in chemokine receptor function.

Cell chemotaxis requires the acquisition and maintenance of both spatial and functional asymmetry between initially equivalent cell parts. In leukocytes one becomes the leading edge and the other, the rear edge or uropod. The acquisition of this cell polarity is controlled by an array of chemoattractants, including those of the chemokine family. We propose that chemokine receptor activation in highly organized lipid raft domains is a major determinant for the correct localization of the signaling pathways leading to the cell asymmetries required for migration. The lateral organization imposed by membrane raft microdomains is discussed in the context of other chemokine receptor activities, such as its role as a human immunodeficiency virus (HIV) coreceptor.
Multimedia quality assessment

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Multimedia Quality assessment Fatih Porikli, Al Bovik, Chris Plack, Alregib Ghassan, Joyce Farrell, Patrick Le Callet, Quan Huynh-Thu, Sebastian Möller, Stefan Winkler
Immune activation is required for the induction of liver allograft tolerance: Implications for immunosuppressive therapy

Liver transplants in many animal models are unusual because often they are not rejected even when transplanted across complete major histocompatibility complex barriers without immunosuppression. Their paradoxical behavior is even more obvious when the immune mechanism of acceptance is examined. Instead of acceptance resulting from a lack of immune response to the graft, the opposite occurs, and there is an unusual extensive increase in immune activation in acceptance compared with rejection. This abnormal extensive immune activation is driven by donor leukocytes transferred with the liver and results in death of the recipient cells that would normally reject the transplant. Some forms of immunosuppression inhibit this activation‐associated liver transplant tolerance. The significance of these findings and possible means to design future treatment protocols for clinical transplantation that optimize management of liver transplant recipients are discussed.
Real-time navigation for a personal mobility in an environment with pedestrians

This paper describes a navigation system in a dynamic environment for a two-wheeled inverted pendulum mobile robot, PMR. Our system is organized by localization, detection and tracking of pedestrians, and trajectory planner. The localization is robust to effects of moving obstacles and pitching movements of the robot, and the trajectory planner creates a path with a certain smoothness considering movements of pedestrians. In addition, the planner introduces strategies to avoid pedestrians to be friendly to pedestrians around the robot. Besides, our system can run on two laptop PCs in real time. Finally, we show experimental results as well.