Miracle-dz/UniFAR-FTUs huggingface dataset:
A Review of Current Evidence with Continuous Glucose Monitoring in Patients with Diabetes

Devices that measure glucose on a near-continuous basis may provide a better insight into glycemic profiles, allowing patients with diabetes to make therapeutic adjustments to improve metabolic control, thereby reducing the risk of diabetic complications. Motivated and technologically adept patients with brittle diabetes, hypoglycemia unawareness, diabetic pregnancy, or who use pumps might benefit. Current evidence of continuous glucose monitoring (CGM) on health outcome in patients with diabetes is critically reviewed. No data are available on chronic complications or mortality. Therefore, surrogate endpoints need to be investigated, particularly HbA1c, number of hypo- and hyperglycemic episodes, time within normal, high, or low glucose concentrations, glycemic variability, and quality of life. Randomized controlled trials (RCTs) using CGM in a retrospective way did not show metabolic improvement. In contrast, most RCTs applying real-time CGM showed a decrease in HbA1c, reduced glycemic variability, and a diminished number and length of hypo- and hyperglycemic events. Using accurate, real-time CGM devices improves quality of life by reducing the fear of unexpected hypoglycemic events. These beneficial effects were observed despite the fact that in most studies no clear treatment algorithm based on CGM results was provided to the patients. However, most trials were too short in duration, with a variable use of CGM, and were performed in small study samples. In conclusion, real-time CGM systems can improve metabolic control, reduce hypoglycemic episodes, and improve quality of life. Whether this holds true for longer time periods and in the majority of patients remains to be proven. In the long term, CGM might help to reduce chronic diabetes complications and perhaps also mortality, thereby reducing health care costs.
Parental Control of Pre-School Children's Viewing of Programmes in Electronic Media

Electronic media comprise an integral part of family life and have therefore become the children’s companions. The programmes that children watch from early childhood affect their psychological development and shape their moral norms, attitudes and opinions. One of the important tasks of parents is to define rules for watching programmes in the electronic media, to decide at what age children should start watching programmes, which programmes are appropriate for them, for how long and during which part of the day they can spend time in front of the screen. The research problem how parents control and manage TV viewing in their pre-school children has been studied using qualitative research methods – in-depth interviews as the main research method phenomenological analysis. This research offers findings on what the viewing habits of a child television view are in the families of our participants. It examines the environment and the context of the family activities as a part of which the children watched TV. For a more thorough understanding of the parenting techniques using which parents seek to control children’s television viewing, part of the research interview is given to the view of parents on TV, the positive and negative effects, which, according to the parents, watching television can bring their children.
Qualitative Properties of Steady-State Poisson-Nernst-Planck Systems: Mathematical Study

We examine qualitative properties of solutions of self-consistent Poisson--Nernst--Planck systems, including uniqueness. In the case of vanishing permanent charge, the predominant case studied, our results unveil a rich structure inherent in these systems, one that is determined by the boundary conditions and the signs of the oppositely charged carrier fluxes. A particularly significant special case, that of simple boundary conditions, is shown to lead to uniqueness and to a complete characterization. This case underlies the more complicated cases studied later. A contraction mapping principle is included for completeness and allows for an arbitrary permanent charge distribution.
Fundamental-measure free-energy density functional for hard spheres: Dimensional crossover and freezing

A geometrically based fundamental-measure free-energy density functional unified the scaled-particle and Percus-Yevick theories for the hard-sphere fluid mixture. It has been successfully applied to the description of simple ~‘‘atomic’’ ! three-dimensional ~3D! fluids in the bulk and in slitlike pores, and has been extended to molecular fluids. However, this functional was unsuitable for fluids in narrow cylindrical pores, and was inadequate for describing the solid. In this work we analyze the reason for these deficiencies, and show that, in fact, the fundamental-measure geometrically based theory provides a free-energy functional for 3D hard spheres with the correct properties of dimensional crossover and freezing. After a simple modification of the functional, as we propose, it retains all the favorable D53 properties of the original functional, yet gives reliable results even for situations of extreme confinements that reduce the effective dimensionality D drastically. The modified functional is accurate for hard spheres between narrow plates (D52), and inside narrow cylindrical pores ( D51), and it gives the exact excess free energy in the D50 limit ~a cavity that cannot hold more than one particle! It predicts the ~vanishingly small! vacancy concentration of the solid, provides the fcc hard-sphere solid equation of state from closest packing to melting, and predicts the hard-sphere fluid-solid transition, all in excellent agreement with the simulations. @S1063-651X~97! 07404-7#
Knowledge Management: A Blueprint for Delivery

Some people may be laughing when looking at you reading in your spare time. Some may be admired of you. And some may want be like you who have reading hobby. What about your own feel? Have you felt right? Reading is a need and a hobby at once. This condition is the on that will make you feel that you must read. If you know are looking for the book enPDFd knowledge management a blueprint for delivery as the choice of reading, you can find here.
Development and Initial Validation of a Virtual Reality Haptically Augmented Surgical Knot-Tying Trainer for the Autosuture™ ENDOSTITCH™ Instrument

The Autosuture Endostitch device (Covidien, CT) is difficult to learn. In particular, the handle requires the use of a toggle which is unique in this instrument. We have developed a virtual reality trainer for the device that offers the use of the actual instrument handle while creating a visible virtual instrument tip complete with virtual needle and suture on a monitor. This report represents the development and initial validation experiments for the device.
Fusidic acid alone or in combination with vancomycin for therapy of experimental endocarditis due to methicillin-resistant Staphylococcus aureus

The usefulness of fusidic acid, alone or combined with vancomycin, was investigated for the therapy of experimental endocarditis caused in rabbits by a methicillin-resistant strain of Staphylococcus aureus. In vitro killing curves showed an indifferent interaction between the two antibiotics. In vivo, vancomycin alone was as effective as a vancomycin-fusidic acid combination (P < 0.05 versus control animals). No resistance to fusidic acid emerged during combination therapy. Fusidic acid alone was not effective. Resistance emerged in 5 of 12 animals treated with fusidic acid alone and was responsible for antibacterial failure. Fusidic acid alone was effective (P < 0.001) and did not select resistant strains if therapy was started when animals retained a smaller inoculum. We concluded that the vancomycin-fusidic acid combination exhibited no advantage over vancomycin alone in this model.
A 1x1 802.11n WLAN SoC with fully integrated RF front-end utilizing PA linearization

A 1x1 2.4GHz 802.11n draft compliant radio SoC with fully integrated front-end is presented. A linearized power amplifier is merged with a low noise amplifier to form an RF front end with built-in transmit/receive switch functionality. In HT20 mode, the radio can transmit 19.4dBm spectral mask compliant power and 18.4dBm EVM-compliant power at 65Mbps rate. The sensitivity from the port shared with the PA is −97 dBm at 1Mbps rate.
Contribution à l'étude théorique, à la modélisation et à la mise en oeuvre d'un système multisource appartenant à un micro-réseau électrique : considération sur la qualité de l'énergie

L’objectif de cette these est d’etudier, d’analyser et de developper un systeme multisource appartenant a un micro-reseau DC avec la prise en consideration de quelques aspects de la qualite de l’energie. Le chapitre I presente l’interet du reseau intelligent afin d’assurer la meilleure coordination entre la production d’electricite distribuee et la consommation electrique. En vue de la prediction, un modele purement experimental de la source photovoltaique est developpe et presente dans le chapitre II. Par ailleurs, afin d’extraire la puissance maximale de la source photovoltaique, un algorithme classique est ameliore et compare energetiquement avec trois autres methodes. Dans le chapitre III, les elements de la securisation du systeme multisource, soit le stockage electrochimique et le reseau public, sont caracterises. Dans le cas d’un deficit du stockage, le reseau public est utilise pour assurer l’alimentation de la charge, mais aussi pour evacuer le surplus d’energie. Le chapitre IV est consacre au controle du systeme multisource et a sa validation experimentale. La commutation entre les elements de la securisation du systeme global fait l’objet d’une strategie de gestion d’energie dans laquelle la priorite est donnee au stockage caracterise par son etat de charge. Grâce a cette strategie, la faisabilite technique du systeme multisource est experimentalement validee. Le chapitre V presente quelques aspects portant sur l’amelioration de la qualite de l’energie : du cote reseau public un correcteur resonnant est propose, du cote bus continu on elimine la puissance pulsante par l’injection de son oppose a l’aide du stockage electrochimique.
A framework for joint facial expression recognition and point localization

Unlike many approaches that use detected facial points to infer facial expressions, in this work, we propose an approach in which we jointly tackle the two tasks on a frame basis. After ensuring the consistent face cropping, our framework makes use of geometric- and appearance- based methods for the facial expression recognition, and of cascade regression and local-based methods for the facial point detection. For the data fusion, we adapted the Viterbi algorithm. The training and testing were carried out on two public benchmark databases. With the proposed framework, we improved the recognition rate of the facial expression and the accuracy of the facial point localization by at least 5.4% and 8.9%, respectively, in comparison to the conventional sequential methods.
La naturaleza y sus fines en la discusiÓn sobre el vacío desde el siglo XIII hasta el siglo XVII

Departing from Pierre Duhem's study, the article shows that an important number of Medieval, Renaissance and Early Modern authors have postulated the same teleological principle in supporting the deny of the existence of the vacuum. That principle holds that the particular and specific nature have to be subdued to the common and universal nature in order to conserve the good of nature. As a result, although it is observed a conceptual continuity which assumes a teleological structure, variations arise, when the attention is drawing to the context and the time.
Neurofibromatosis type I gene mutation in a patient with features of LEOPARD syndrome

Multiple lentigines (LEOPARD) syndrome has been delineated as an autosomal dominant disorder with lentigines, cardiac abnormalities, variable mental retardation, and typical craniofacial features as the most characteristic findings. LEOPARD syndrome shows a great clinical overlap with neurofibromatosis type 1 (NF1). In this report we describe a de novo missense mutation (M 1035R) in exon 18 of the NF1 gene in a young woman with a prior diagnosis of LEOPARD syndrome. We hypothesize that some patients now diagnosed with LEOPARD syndrome have in fact a mutation in the NF1 gene, whereas in other patients with LEOPARD syndrome, a different gene might be involved. © 1996 Wiley‐Liss, Inc.
The Enhancement or Prevention of Airway Hyperresponsiveness during Reinfection with Respiratory Syncytial Virus Is Critically Dependent on the Age at First Infection and IL-13 Production1

Respiratory syncytial virus (RSV) infection in early life is suspected to play a role in the development of postbronchiolitis wheezing and asthma. Reinfection is common at all ages, but factors that determine the development of altered airway function after reinfection are not well understood. This study was conducted in a mouse model to define the role of age in determining the consequences on airway function after reinfection. Mice were infected shortly after birth or at weaning and were reinfected 5 wk later, followed by assessment of airway function, airway inflammation, and lung histopathology. Infection of mice at weaning elicited a protective airway response upon reinfection. In this age group, reinfection resulted in increased airway inflammation, but without development of airway hyperresponsiveness (AHR) or eosinophilia and decreased IL-13 levels. By contrast, neonatal infection failed to protect the airways and resulted in enhanced AHR after reinfection. This secondary response was associated with the development of airway eosinophilia, increased IL-13 levels, and mucus hyperproduction. Both CD4- and CD8-positive T cells were a source of IL-13 in the lung, and inhibition of IL-13 abolished AHR and mucus production in these mice. Inoculation of UV-inactivated virus failed to elicit these divergent responses to reinfection, emphasizing the requirement for active lung infection during initial exposure. Thus, neonatal RSV infection predisposes to the development of airway eosinophilia and enhanced AHR via an IL-13-dependent mechanism during reinfection, whereas infection at a later age protects against the development of these altered airway responses after reinfection.
Treatment for preventing tuberculosis in children and adolescents: a randomized clinical trial of a 3-month, 12-dose regimen of a combination of rifapentine and isoniazid.

IMPORTANCE Three months of a once-weekly combination of rifapentine and isoniazid for treatment of latent tuberculosis infection is safe and effective for persons 12 years or older. Published data for children are limited. OBJECTIVES To compare treatment safety and assess noninferiority treatment effectiveness of combination therapy with rifapentine and isoniazid vs 9 months of isoniazid treatment for latent tuberculosis infection in children. DESIGN, SETTING, AND PARTICIPANTS A pediatric cohort nested within a randomized, open-label clinical trial conducted from June 11, 2001, through December 17, 2010, with follow-up through September 5, 2013, in 29 study sites in the United States, Canada, Brazil, Hong Kong (China), and Spain. Participants were children (aged 2-17 years) who were eligible for treatment of latent tuberculosis infection. INTERVENTIONS Twelve once-weekly doses of the combination drugs, given with supervision by a health care professional, for 3 months vs 270 daily doses of isoniazid, without supervision by a health care professional, for 9 months. MAIN OUTCOMES AND MEASURES We compared rates of treatment discontinuation because of adverse events (AEs), toxicity grades 1 to 4, and deaths from any cause. The equivalence margin for the comparison of AE-related discontinuation rates was 5%. Tuberculosis disease diagnosed within 33 months of enrollment was the main end point for testing effectiveness. The noninferiority margin was 0.75%. RESULTS Of 1058 children enrolled, 905 were eligible for evaluation of effectiveness. Of 471 in the combination-therapy group, 415 (88.1%) completed treatment vs 351 of 434 (80.9%) in the isoniazid-only group (P = .003). The 95% CI for the difference in rates of discontinuation attributed to an AE was -2.6 to 0.1, which was within the equivalence range. In the safety population, 3 of 539 participants (0.6%) who took the combination drugs had a grade 3 AE vs 1 of 493 (0.2%) who received isoniazid only. Neither arm had any hepatotoxicity, grade 4 AEs, or treatment-attributed death. None of the 471 in the combination-therapy group developed tuberculosis vs 3 of 434 (cumulative rate, 0.74%) in the isoniazid-only group, for a difference of -0.74% and an upper bound of the 95% CI of the difference of +0.32%, which met the noninferiority criterion. CONCLUSIONS AND RELEVANCE Treatment with the combination of rifapentine and isoniazid was as effective as isoniazid-only treatment for the prevention of tuberculosis in children aged 2 to 17 years. The combination-therapy group had a higher treatment completion rate than did the isoniazid-only group and was safe. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00023452.
A unified model for the action of leptin on bone turnover

Leptin has been advocated as a centrally acting factor responsible for inhibiting accumulation of bone mass. However, recent investigations unequivocally establish leptin as a local (autocrine) factor expressed by osteoblasts. Exogenously added leptin causes osteoblastic cell proliferation and differentiation, while also rendering osteoblasts more efficacious in terms of mineralization. Leptin acts as an anti‐apoptotic agent, and augments messages responsible for the remodelling of bone tissue, i.e., mRNAs for osteoprotegerin (OPG) and the interleukin IL‐6. Furthermore, leptin message is readily expressed in osteoblasts subjected to mechanical strain. In this respect, osteoblasts, which are unilaterally stretched proliferate and differentiate, a phenomenon being potentiated by exposure of the cells to differentiating humoral factors. This article discusses a unified model of dually acting leptin through the central nervous system and the mechanostat principle applied to osteoblasts. The proposed model may account for the finely tuned bone homeostasis maintained within rather narrow limits, depending on exposure to humoral factors and the prevailing mechanostat usage mode. © 2002 Wiley‐Liss, Inc.
Small Business Financing for Supporting SMEs in Indonesia: A Conceptual Study

Small and medium enterprises (SMEs) are the main pillars of a country economy, especially within developing countries. These types of businesses have existed since the Dutch colonial era. However, their existence is now threatened due to the rapid expansion of modern businesses that have spread into rural areas of Indonesia. Therefore, SMEs are in dire need of government assistance from both central and local governments, from a financial and non-financial perspective. In order to strengthen the SMEs’ capital, so that they are able to sustain their businesses, this chapter intends to propose a financing model for SMEs that could be given by the government through financial institutions, so that SMEs will be able to gain easy access to capital resources. In the other words, this condition is expected to give maximum support to the development of SMEs. As a result, the SMEs will contribute to eradicating unemployment and poverty by strengthening the economy of Indonesia. Small Business Financing for Supporting SMEs in Indonesia: A Conceptual Study
Sustained-release from Layered Matrix System Comprising Chitosan and Xanthan Gum

ABSTRACT Sustained-release tablets of propranolol HCl were prepared by direct compression using chitosan and xanthan gum as matrix materials. The effective prolongation of drug release in acidic environment was achieved for matrix containing chitosan together with xanthan gum which prolonged the drug release more extensive than that containing single polymer. Increasing lactose into matrix could adjust the drug release characteristic by enhancing the drug released. Component containing chitosan and xanthan gum at ratio 1:1 and lactose 75% w/w was selected for preparing the layered matrix by tabletting. Increasing the amount of matrix in barrier or in middle layer resulted in prolongation of drug release. From the investigation of drug release from one planar surface, the lag time for drug release through barrier layer was apparently longer as the amount of barrier was enhanced. Least square fitting the experimental dissolution data to the mathematical expressions (power law, first order, Higuchi's and zero order) was performed to study the drug release mechanism. Layering with polymeric matrix could prolong the drug release and could shift the release pattern approach to zero order. The drug release from chitosan-xanthan gum three-layer tablet was pH dependent due to the difference in charge density in different environmental pH. FT-IR and DSC studies exhibited the charge interaction between of NH3+ of chitosan molecule and COO− of acetate or pyruvate groups of xanthan gum molecule. The SEM images revealed the formation of the loose membranous but porous film that was due to the gel layer formed by the polymer relaxation upon absorption of dissolution medium. The decreased rate of polymer dissolution resulting from the decreased rate of solvent penetration was accompanied by a decrease in drug diffusion due to ionic interaction between chitosan and xanthan gum. This was suggested that the utilization of chitosan and xanthan gum could give rise to layered matrix tablet exhibiting sustained drug release.
Sentiment Analysis on Product-Service Systems

The main goal of this dissertation is to develop a tool to help each company reduce the amount of failed product-service systems that were avoidable due previous experience. By using tools and ideas already available and build them in a way they can interact with each other, this tool aims to give designers a better as faster way to view data. This was identified as a possible improvement since for the past 20 years the economy evolved into a consumer driven market, this led to the development of an extremely competitive economy. Companies need to strive for innovation and quality of products and services, faster than never. Products and services also need to match the expectations and needs of customers. Analyzing where product and service systems are lacking in terms of customer requirements is crucial. Currently it might take some time for information to travel from customer to producer, since the connection may include stores and local representatives before reaching the products’ and services’ designers. Although this information is readily available in social networks, the issue resides in efficiently merging and showing it in a simple and meaningful way to the designer of new products and systems. By shortening the time spent for information travel between costumer and producer, might lead to better and more innovative products.