Miracle-dz/UniFAR-FTUs huggingface dataset:
A secure and flexible e-Health access control system with provisions for emergency access overrides and delegation of access privileges

Protecting electronic health records (EHR) from unauthorized access and data breaches has been a great challenge for healthcare organizations in recent times. Controlling access to EHR demands a delicate balance between security and flexibility: There are emergency cases where the default access control policy must be circumvented in order to save patients' life - and cases where management of access control rights needs to be delegated to some trusted parties. Therefore, e-Health access control systems must be robust and flexible at the same time. Conventional general-purpose access control schemes like role-based access control (RBAC) and its derivatives emphasize mainly on the robustness of the access control mechanism, and treat flexibility issues like emergency access overrides and delegation management as addenda. However, in order to comply with the care first principle of the healthcare domain, an ideal e-Health access control system should consider such flexibility issues from the ground up. Recognizing these special requirements mandated by the very nature of the healthcare profession, in this paper, we propose a secure and flexible access control system for e-Health. The user-role and object-operation mappings in our proposed system lend themselves to the RBAC model, and we implemented context verification atop this layer in order for the system to make access decision responsive to emergency incidents. For managing delegation of access control rights, we developed a secure mechanism for creation, transfer and verification of a delegation token, presentation of which to the access control system enables a delegatee to access a delegator's EHR. Every access request in our system is preceded by mandatory user authentication which we implemented using eTRON tamper-resistant cards. Security and performance analysis of the proposed system showed promising results for achieving the desired level of balance between security and flexibility required for an e-Health access control system.
Osteoporotic vertebral fractures: diagnosis with radiography and bone scintigraphy.

PURPOSE To determine the radiographic appearance of osteoporotic vertebral fracture. MATERIALS AND METHODS Lateral thoracic and lumbar spine radiographs were examined in 58 patients (812 vertebra) with osteoporosis and evidence of vertebral collapse at bone scintigraphy. Scintigraphic activity was graded as faint, moderate, or intense. Anterior, middle, and posterior heights of the T-4 to L-5 vertebrae were measured. The degree of vertebral deformity was derived by comparing a ratio of heights with the normal mean. RESULTS At radiography, 378 of the 812 vertebrae (47%) were normal, 434 (53%) had deformities that were more than two standard deviations (SDs) below the normal mean, 304 (37%) had deformities that were more than three SDs below the normal mean, and 222 (27%) had deformities that were more than four SDs below the normal mean. Of 86 vertebrae that showed moderate or intense radionuclide uptake at scintigraphy, all had deformities that were more than two SDs below the normal mean, and 80 (93%) had deformities that were more than three SDs below the normal mean. CONCLUSION Only in vertebrae with deformities more than three SDs below the normal mean can fractures be confidently diagnosed.
Prognostic Factors Affecting Progression and Survival in Metastatic Prostate Cancer

Purpose: To evaluate the role of age, Gleason score, prostate-specific antigen (PSA), PSA doubling time (PSADT), and PSA half-time (PSAT1/2) as prognostic factors in metastatic prostate cancer to predict long-term outcome. Patients and Methods: 412 patients with metastatic prostate cancer diagnosed after January 1995, with at least 6 months of follow-up, were enrolled. Serum PSA was determined at diagnosis and every 3–6 months thereafter. All patients underwent medical or surgical castration. End points of the study were either death or disease progression. Univariate and multivariate Cox proportional hazard analysis was used to evaluate prognostic factors. Results: Median progression-free and overall survival was 3 and 5.7 years. Patients aged ≤65 years at diagnosis, high baseline PSA and high nadir PSA were associated with poor overall survival. Patients with a PSAT1/2 of <6 months, high baseline alkaline phosphatase, and PSADT of <1 month had significantly poorer progression-free and overall survival. Conclusion: Prostate cancer is a common malignancy in the elderly population. We have found that younger patients with high baseline and nadir PSA, shorter PSADT and PSAT1/2 have poorer overall and progression-free survival.
Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials.

PURPOSE Two identical, concurrent, parallel, multicenter, randomized, double-blind, double-dummy trials were conducted to compare the efficacy and safety of zoledronic acid and pamidronate for treating hypercalcemia of malignancy (HCM). PATIENTS AND METHODS Patients with moderate to severe HCM (corrected serum calcium [CSC] > or = 3.00 mmol/L [12.0 mg/dL]) were treated with a single dose of zoledronic acid (4 or 8 mg) via 5-minute infusion or pamidronate (90 mg) via 2-hour infusion. A protocol-specified pooled analysis of the two parallel trials was performed. Clinical end points included rate of complete response by day 10, response duration, and time to relapse. RESULTS Two hundred eighty-seven patients were randomized and evaluated for safety; 275 were evaluated for efficacy. Both doses of zoledronic acid were superior to pamidronate in the treatment of HCM. The complete response rates by day 10 were 88.4% (P = .002), 86.7% (P = .015), and 69.7% for zoledronic acid 4 mg and 8 mg and pamidronate 90 mg, respectively. Normalization of CSC occurred by day 4 in approximately 50% of patients treated with zoledronic acid and in only 33.3% of the pamidronate-treated patients. The median duration of complete response favored zoledronic acid 4 and 8 mg over pamidronate 90 mg with response durations of 32, 43, and 18 days, respectively. CONCLUSION Zoledronic acid is superior to pamidronate; 4 mg is the dose recommended for initial treatment of HCM and 8 mg for relapsed or refractory hypercalcemia.
Cardiovascular design in fin whales: high-stiffness arteries protect against adverse pressure gradients at depth

SUMMARY Fin whales have an incompliant aorta, which, we hypothesize, represents an adaptation to large, depth-induced variations in arterial transmural pressures. We hypothesize these variations arise from a limited ability of tissues to respond to rapid changes in ambient ocean pressures during a dive. We tested this hypothesis by measuring arterial mechanics experimentally and modelling arterial transmural pressures mathematically. The mechanical properties of mammalian arteries reflect the physiological loads they experience, so we examined a wide range of fin whale arteries. All arteries had abundant adventitial collagen that was usually recruited at very low stretches and inflation pressures (2–3 kPa), making arterial diameter largely independent of transmural pressure. Arteries withstood significant negative transmural pressures (−7 to −50 kPa) before collapsing. Collapse was resisted by recruitment of adventitial collagen at very low stretches. These findings are compatible with the hypothesis of depth-induced variation of arterial transmural pressure. Because transmural pressures depend on thoracic pressures, we modelled the thorax of a diving fin whale to assess the likelihood of significant variation in transmural pressures. The model predicted that deformation of the thorax body wall and diaphragm could not always equalize thoracic and ambient pressures because of asymmetrical conditions on dive descent and ascent. Redistribution of blood could partially compensate for asymmetrical conditions, but inertial and viscoelastic lag necessarily limits tissue response rates. Without pressure equilibrium, particularly when ambient pressures change rapidly, internal pressure gradients will develop and expose arteries to transient pressure fluctuations, but with minimal hemodynamic consequence due to their low compliance.
The effect of warm up on single and intermittent-sprint performance

Abstract Lack of benefit of warm up on prolonged intermittent-sprint performance has been proposed to be due to use of a pacing strategy by participants. To investigate this, twelve participants performed four cycle trials that consisted of either prolonged intermittent-sprint performance (80 min) or single-sprint performance (4 s), with or without a warm up. The first-sprint ofintermittent-sprint performance was also assessed. No interaction effects (P > 0.05) were found between trials for intermittent-sprint performance for total work (J · kg−1), or percentage work and power decrement. Work done during the first-sprint of intermittent-sprint performance (no warm up) was less (P < 0.001) than the first-sprint of intermittent-sprint performance (warm up; effect size (ES) = 0.59) and both single-sprint trials (warm up and no warm up; ES = 0.91, 0.75, respectively). Peak power (W · kg−1) for single-sprint (warm up) was greater (P < 0.05) than single-sprint (no warm up), and the first-sprint of intermittent-sprint performance (warm up and no warm up). Warm up improved single-sprint performance and the first sprint of intermittent-sprint performance. Use of a pacing strategy probably resulted in similar intermittent-sprint performance between trials. These results suggest that team-sport players should perform a warm up at the start of a game or before substitution during a game.
[Effects of social inequalities on coronary heart disease risk factors: a population-based, cross-sectional study in Izmir].

OBJECTIVE Aim of the study was to determine effects of social inequalities on coronary heart disease risk factors in individuals living in an urban district of Izmir; namely Balçova. METHODS In this cross-sectional study, no sampling was done and it was aimed to reach all residents living in that area aged 30 years and over (n=4409). Dependent variables were smoking, physical inactivity, unhealthy diet, obesity, hypertension, diabetes, dyslipidemia where social inequality was the independent variable. Educational status, income and social class were considered as the components of social inequality. Age, gender, family health histories were the confounding factors. Data were collected at home and in the neighborhood-house. For data analyses Chi-square test, and logistic regression analysis were used. RESULTS Smoking is higher in men and women in lower socio economic class, where unhealthy diet is higher in self-employed men (OR=9.24, 95% CI=1.14-74.81, p=0.037) and in women who have a lower education (OR=1.53, 95% CI=1.02-2.30, p=0.040), lower income or unemployed (OR=3.43, 95% CI=1.28-9.14, p=0.014). Obesity is more frequent in lower educated women (OR=1.89, 95% CI=1.37-2.59, p<0.001) where decreased high-density lipoprotein cholesterol (HDL-C) is more frequent in men who have lower income (OR=2.21, 95% CI=1.20-4.07, p=0.011). Men who have a lower education (OR=0.61, 95% CI=0.38-0.98, p=0.039) or working as a skilled (OR=0.37, 95% CI=0.16-0.89, p=0.027) or an unskilled worker (OR=0.35, 95% CI=0.15-0.82, p=0.016) tend to have a decreased risk of obesity when working as a skilled worker (OR=0.53, 95% CI=0.29-0.95, p=0.033) decreases elevated low-density lipoprotein cholesterol. CONCLUSION Coronary heart disease risk factors are high among participants who are aged 30 years and over. Men are under higher risk than women are. An increase in social inequalities causes decreased HDL-C in men, and increased smoking, unhealthy diet and obesity in women.
Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women.

UNLABELLED Creatine monohydrate (CrM) administration may enhance high intensity exercise performance and increase body mass, yet few studies have examined for potential adverse effects, and no studies have directly considered potential gender differences. PURPOSE The purpose of this study was to examine the effect of acute creatine supplementation upon total and lean mass and to determine potential side effects in both men and women. METHODS The effect of acute CrM (20 g x d(-1) x 5 d) administration upon systolic, diastolic, and mean BP, plasma creatinine, plasma CK activity, and body composition was examined in 15 men and 15 women in a randomized, double-blind experiment. Additionally, ischemic isometric handgrip strength was measured before and after CrM or placebo (PL). RESULTS CrM did not affect blood pressure, plasma creatinine, estimated creatinine clearance, plasma CK activity, or handgrip strength (P > 0.05). In contrast, CrM significantly increased fat-free mass (FFM) and total body mass (P < 0.05) as compared with PL, with no changes in body fat. The observed mass changes were greater for men versus women. CONCLUSIONS These findings suggest that acute CrM administration does not affect blood pressure, renal function, or plasma CK activity, but increases FFM. The effect of CrM upon FFM may be greater in men as compared with that in women.
BioMEMS implants for neural regeneration after a spinal cord injury

Functional restoration is one of the major obstacles for spinal cord traumatic patient. Neural Regeneration is considered one of the strategies for functional recovery after spinal cord injury. Neurons can regenerate if they are provided with the favorable environment. Substantial efforts have been directed at understanding the central nervous system environment and the means of modifying it to an appropriate medium for neural regeneration. Over the past decade BioMEMS implants have been used as neural interfaces for promoting axon growth. This article reviews the usage of BioMEMS implants as electrical stimulation neural interface and as hybrid ones. Animal experiments of these neural interfaces have presented important results that hopefully the treatment for injured spinal cord will be developed in the near future.
Vitronectin is present in epithelial cells of the intact lens and promotes epithelial mesenchymal transition in lens epithelial explants.

PURPOSE Extracellular matrix (ECM) accumulates during the development of posterior capsule opacification (PCO). Vitronectin, an ECM component that is generally prominent in wound healing, has been detected in PCO specimens. Here we set out to investigate the distribution of vitronectin in the lens and determine how it, and other ECM components, influence the lens epithelial phenotype. METHODS Rat lens epithelial explants were cultured on vitronectin, fibronectin, and laminin substrata. Explants were monitored for cell migration and the appearance of markers for epithelial mesenchymal transition (EMT), using phase contrast microscopy and immunohistochemistry, respectively. Explants were also monitored for evidence of Smad signaling. Vitronectin expression was analyzed in embryonic and postnatal rodent lens development by immunohistochemistry, western blotting, and in situ hybridization. RESULTS Vitronectin, like fibronectin and laminin, provided a good substratum for cellular attachment and migration. However, in the case of vitronectin and fibronectin, this was accompanied by a major phenotypic change. On either vitronectin or fibronectin, but not laminin, most of the cells became elongated, spindle-shaped and were strongly reactive for filamentous alpha-smooth muscle actin. In these respects this transition was typical of the well known TGFbeta-induced EMT. In explants cultured on vitronectin and fibronectin, but not laminin, cell nuclei showed prominent reactivity for Smad 2/3. Vitronectin was also shown to be expressed during embryonic and postnatal development. Initially mRNA and protein were detected in all lens cells, however as development progressed, expression became restricted to cells of the epithelium and transition zone. CONCLUSIONS The results clearly show that lens cell engagement with a vitronectin or a fibronectin, but not laminin, substratum has a potent EMT promoting effect and that Smad 2/3 signaling is involved. Thus when considering strategies to slow or prevent PCO, these results highlight the need to take into account ECM molecules such as vitronectin that have the capacity to promote EMT.
A Compact MIMO Antenna For UWB Applications

S D Priya Sankari, PG Scholar, KLN College of Information Technology, Pottapalayam. Abstract The communication industry field is mainly focused by high data transfer and more channel capacity in mobile communication. The monopole resonator antenna which is used to radiate in the omni directional pattern is used for multi broadcasting. Ultra wide band antenna technology is used for transmitting the information through large bandwidth. The proposed work is to design an Ultra Wide Band two-square monopole antenna. The designed antenna has low profile of complexity and it is used to increase the frequency band level. The resulting antenna reduces the overall insertion loss and return loss. The substrate used is FR-4 (Flame Retardant) which has dielectric constant of 4.4. This antenna requires low cost and compact size. This ultra wide band antenna provides ease to the integration of devices. In this paper, the performance of using circular patch with and without slots and the square patch with and without ground stub and slots and strips are analyzed and compared. It is shown that square patch with the ground stub using slots and strips are having the expected performance.
White Racism, Antiracism, and School Leadership Preparation

This article emerges from a belief that an overwhelming majority of White school leaders do not have a thorough enough understanding of White racism or the ways in which they are perpetuating White racism in their schools, even though most are well-meaning individuals. The lack of understanding or awareness of different forms of racism and how White racism works is highly problematic. Indeed, it has appalling consequences, detrimentally impacting the lives and dreams of millions of children. In this article, we draw from both literature and experience to argue for the incorporation of antiracism in school leadership programs. We begin with the assertion that because Educational Administration programs function as important agents of socialization for our future school leaders, White racism in all its manifestations must be confronted in these programs. After building the case that racism is enacted by teachers and administrators in schools and demonstrating the harmful effects of White racism on both children and adults, we argue that racism is not being adequately addressed in educational administration programs. Subsequently, we offer guidance to our readers for promoting antiracism among future educational leaders.
A 210 kDa nuclear matrix protein is a functional part of the mitotic spindle; a microinjection study using SPN monoclonal antibodies.

Six monoclonal antibodies identify a 210 kDa polypeptide which shows a cell cycle specific redistribution from the nucleus to the mitotic spindle. In interphase cells this polypeptide was localized in the nucleus and behaved during differential cell extraction as a component of the nuclear matrix. It accumulated in the centrosome region at prophase, in the pole regions of the mitotic spindle at metaphase and in crescents at the poles in anaphase, and reassociated with the nuclei as they reformed in telophase. Due to its staining pattern we call the protein the Spindle Pole‐Nucleus (SPN) antigen. The localization of SPN antigen during mitosis was dependent on the integrity of the spindle since treatment of cells with nocodazole resulted in the dispersal of SPN antigen into many small foci which acted as microtubule organizing centres when the drug was removed. The SPN antigen was present in nuclei and mitotic spindles of all human and mammalian cell lines and tissues so far tested. When microinjected into the cytoplasm or nuclei of HeLa cells, one antibody caused a block in mitosis. Total cell number remained constant or decreased slightly after 24 h. At this time, about half the cells were arrested in a prometaphase‐like state and revealed aberrant spindles. Many other cells were multinucleate. These results show that the SPN antigen is a protein associated with mitotic spindle microtubules which has to function correctly for the cell to complete mitosis.
Market Timing with Option-Implied Distributions in an Exponentially Tempered Stable Lévy Market

This paper explores the empirical implementation of a dynamic asset allocation strategy using option-implied distributions when the underlying risky asset price is modeled by an exponential Levy process. One month risk-neutral densities are extracted from option prices and are subsequently transformed to the risk-adjusted, or real-world densities. Optimal portfolios consisting of a risky and risk-free asset rebalanced on a monthly basis are then constructed and their performance analyzed. It is found that the portfolios formed using option-implied expectations under the Levy market assumption, which are flexible enough to capture the higher moments of the implied distribution, are far more robust to left-tail market risks and offer statistically significant improvements to risk-adjusted performance when investor risk aversion is low, however this diminishes as risk aversion increases.
The Housing Wealth Effect: Quasi-Experimental Evidence

We exploit a quasi-experiment to provide new evidence on the magnitude of the housing wealth effect. We estimate an immediate shock of approximately - 15% to house prices close to one of Stockholm's airports after its operations were unexpectedly continued as a result of political bargaining. This source of price variation is ideal to identify housing wealth effects since it is local and unrelated to variation in macroeconomic conditions. Using a household data set with granular geographic information on location of primary residence, we find an elasticity of 0.45 among purchasers of new cars. Converting our estimate to an aggregate MPC on cars, it is however only 0.13 cents per dollar. The MPC is entirely concentrated to homeowners with a combined loan-to-value ratio between 0.6 and 0.8 which, on the one hand, confirms the key role of household balance sheets but on the other hand refutes a monotone relationship between response and household leverage.