Miracle-dz/UniFAR-FTUs huggingface dataset:
The emerging role of Interleukin-21 as an antineoplastic immunomodulatory treatment option

As immunotherapy gathers momentum in the field of cancer therapeutics, a recently discovered chemokine, IL-21, has drawn attention as a promising immunomodulatory cytokine with antineoplastic effects. The aforementioned capacities of IL-21 have been investigated in phase I, II clinical trials where it has been utilized either as monotherapy or in combination with other agents. Extensive investigation and conduct of larger prospective trials are necessary for further evaluation of this promising immunotherapy modality.
Contextual language understanding Thoughts on Machine Learning in Natural Language Processing

This document is a habilitation a diriger des recherches (HDR) thesis. It is organized in two parts: The first part presents a reflection on my work and the state of the Natural Language Processingcommunity ; The second part is an overview of my activity, including a detailed CV, a summary of the work of the PhD students I contributed to advising, and a list of my personal publications.Self-citations are postfixed with and listed in Chapter 9, while external references are listed in the bibliography at the end of the document. Each contribution chapter ends with a section listing PhDstudent work related to that chapter.
Characteristics and content of intrusive images in patients with eating disorders

Abstract The aim of this study was to examine the characteristics and content of intrusive images in patients with different subtypes of eating disorders (EDs). Data were collected from 74 ED patients, 22 dieting, and 29 nondieting controls. Participants completed a set of self‐report questionnaires. Intrusive images of ED patients were significantly more repetitive, detailed, vivid, and distressing than intrusive images of dieting and/or nondieting controls. Most of the intrusive images were the same for the ED subtypes; however, patients with anorexia nervosa were more likely to report an observer vantage perspective than patients with bulimia nervosa, who were more likely to report a field vantage perspective. As expected, intrusive images' content was related to body checking (weight and shape) or negative self (evaluated by themselves or others). Finally, there were significant associations between intrusive images' vividness and weight and shape concerns. These findings indicate that intrusive images may be a core element of EDs and targeting intrusive images in therapy may be helpful.
Social media Facebook and You Tube usefulness in anatomy learning: experience at Sapienza University of Rome

Digital natives are growing up in a new media ecosystem, where the use of the net and social media is a daily practice. Even if there is a growing interest in the use of social media in university education, there is a paucity of outcome based, empirical studies assessing the impact of social media in medical education, in particular in the Human anatomy field. To facilitate human anatomy learning and teacher-student relation, a Sapienza university of Rome human anatomy teacher (HAT) created a professional Facebook profile (HATPFP) and a You Tube channel dedicated to human anatomy topics (HATYTC). In order to assess the usefulness of social media not only in human anatomy learning but also to get in touch with the human anatomy teacher, at the end of each course a survey was created than distributed to the students of health professions and medicine and surgery degree courses. Our data, the first referring to the Italian context, show a useful and positive opinion by most students on the use of social media Facebook and You Tube in the teaching of Human Anatomy. Although within the limits of an exploratory study, we have highlighted how social media can be an effective support for anatomy teaching by facilitating social interactions (in terms of time reduction, simplification, immediacy, less formality), improving learning (in terms of memorization and understanding of concepts: and notions of anatomy), and making students autonomous in their search for new knowledge of anatomy.
JAK2 Inhibition with TG101348 Inhibits Monosomy 7 Myelodysplastic Syndromes (MDS) Bone Marrow Cells In Vitro: a Potential Targeted Therapy for Monosomy 7 MDS

Abstract 973 The myelodysplastic syndromes (MDS) are bone marrow disorders characterized by cytopenias and a variable risk of progression to acute myeloid leukemia (AML). Monosomy 7 is the second most common cytogenetic abnormality in MDS, and the most frequent karyotypic aberration occurring in aplastic anemia patients following immunosuppressive therapy. Monosomy 7 MDS carries a particularly poor prognosis, with patients manifesting severe cytopenias and a high propensity to develop treatment-refractory AML. There are currently no targeted therapies for this disorder. We previously reported that monosomy 7 bone marrow mononuclear cells (BMMNCs) express high levels of a differentiation-defective granulocyte colony stimulating factor (G-CSF) receptor isoform (IV), an alternative splice variant that exhibits constitutive signaling through the JAK-2 and STAT-1 pathway, while levels of STAT-3 and -5 are unchanged (Sloand et al, PNAS, 2006, 103:14483). As a result, the cell's ability to differentiate is limited, while its ability to proliferate remains intact. Here we examine the effects of the highly selective JAK2 inhibitor TG101348 on monosomy 7 aneuploidy in BMMNCs, as well as the activity of this compound on CD34+ stem cells and CD13+ myeloid cells in culture, and on the JAK-2 signaling apparatus. Incubation of BMMNCs with TG101348 for 5 days significantly decreased absolute numbers of monosomy 7 aneuploid cells in a concentration dependent manner versus vehicle- treated controls (0.187 × 106 vs 1.08 × 106, P=0.007), while diploid cell numbers remained stable (0.338 × 106 vs 0.213 × 106, P=0.50). Flow cytometry experiments demonstrated that incubation with increasing concentrations of TG101348 decreased the absolute number of CD34+CD13- stem cells, and increased numbers of more differentiated CD34-CD13+ myeloid cells, with median CD34+/CD13+ ratios of 6.547 and 2.216 for cells treated with vehicle and 100 nM TG101348, respectively. By immunoblot, STAT-1 protein expression in monosomy 7 BMMNCs treated with 1uM TG101348 was decreased relative to vehicle- treated controls, while there was no difference in STAT-3 and STAT-5 levels. Thus TG101348 decreases monosomy 7 MDS blasts in vitro through inhibition of JAK-2/STAT-1 signaling, a finding that warrants further study of this agent in clinical trials for patients with monosomy 7 MDS and AML. [Figure][1] Disclosures: No relevant conflicts of interest to declare. [1]: pending:yes
Les inhibiteurs des histone déacétylases en onco-hématologie

• Les inhibiteurs des histone deacetylases «sont une nouvelle classe therapeutique prometteuAe ciblant ta regulation epigenetique du cancer. Les donnees in vitro indiquent une activite antitumorale importante liee a la reexpression de genes anti-oncogeniques et aux reactivations de voies apoptotiques et de differenciation. Les etudes pharmacologiques montrent une synergie avec de nombreux traitements actuellement utilises en onco-hematologie. Le profil de toxicite est acceptable (toxicite digestive dominante). Enfin, les donnees cliniques actuelles montrent une Activite dans les lymphomes T cutanes, les myelodysplasies et les leucemies aigues myeloblastiques (LAM). Plus de 50 essais (monotherapies et associations) sont en cours; les facteurs predictifs de reponse ne sont pour l'instant pas determines.
The complete chloroplast genome of Phaeodactylum tricornutum ICE-H isolated from the Antarctic sea ice

Abstract Phaeodactylum tricornutum ICE-H is a single-cell eukaryotic alga that can grow in the extreme Antarctic environment. The complete chloroplast genome of Phaeodactylum tricornutum ICE-H was assembled with the Illumina sequencing. The chloroplast genome was 117,363 bp in size, containing a large single-copy region (LSC, 63,668 bp), a small single-copy region (SSC, 39,871 bp), and a pair of inverted repeat regions (IRs, 13,824 bp each). The overall GC content was 32.15%. A total of 168 genes were predicted including 132 protein-coding genes, 30 tRNAs, and 6 rRNAs. Phylogenetic analysis indicated that Phaeodactylum tricornutum ICE-H was closely related to Didymosphenia geminata.
Regional Boundary Asymptotic Gradient Full-Order Observer in Distributed Parabolic Systems

The purpose of this paper is to explore the concept of the regional boundary asymptotic gradient full order observer (RBAGFO-observer) in connection with the characterizations of sensors structures. Then, we present various results related to different types of measurements, domains and boundary conditions for distributed parameter systems (DPSS) in parabolic systems problem. The considered approach of this work is derived from Luenberger observer theory which is enable to estimate asymptotically the state gradient of the original system on a sub-region of the domain boundary in order that the RBAGFO-observability notion to be achieved. We also show that there exists a dynamical system for the considered system is not BAGFO-observer in the usual sense, but it may be regional RBAGFO-observer.
Advancing Otherness in Management: Why we Need a Positive Minority Manager Stereotype

In Western companies, a “good manager” is thought of as “white and male. ” Unlike the improvement in the issue of female gender and leadership roles, racial stereotyping of minority groups in management as a barrier to moving up the leadership ladder continues, originating in the management theories and models constructed predominantly from a white male’s perspective. This article seeks to disrupt the uncritical “think manager think male think white” hypothesis by focusing on the deconstruction of a “negative minority manager” stereotype. Using a literature review, this paper explores how the visible ‘otherness’ experienced by middle-management minorities and the lack of mentors mirroring their personal success are a barrier to their upward mobility into senior executive positions. The author finds: 1) the representativeness bias that focuses on negative stereotyping of (non-white) managers leads to an adverse impact on this group’s career advancement opportunities, and 2) those who do not find themselves reflected in the stereotype of a “good manager” rarely develop management skills and may be diverted from pursuing managerial careers. After a discussion of the results obtained from the literature review, suggestions on how improvements can be made to advance racial equality in management are provided.
Evolving Exercise Medicine Concepts growing need for Replicable, Economical & All Round Exercise Regimens in Developing Countries.

Background: Exercise has become a commercial industry today. The purpose of a healthy mind in a healthy body has become diluted. We tried to answer the question that does extra money and time spent in gyms have extra benefit over traditional holistic exercise program. Methodology: 20 young healthy adults between 30-40 yrs were divided into 2 groups, 10 who attended the gym and 10 who attended Yoga school to do SuryaNamaskar. At the end of the month, time and money spent on the exercise was evaluated. All participants who before starting exercise were averagely 60-62 points reached 7073 points by SF-12 V2 in both systems of training . Results: Averagely the gym group spent 70 mins six times a week & Rs 12800 in the first month of training. Comparatively, the Suryanamaskar group spent just 30 mins for six days a week & had almost no expense. Therefore to achieve same levels of mental and physical fitness, gymgoers needed more than double the time and approximately more than 12 times the expense. Discussion: The administration should wake up to 1. Need for prevention based health program. 2. Use of traditional systems like yoga to achieve same fitness goals in lesser time with lesser expenses. 3. More studies like this are needed to prevent blind imitation of the western fitness protocols. Conclusion: Exercises like Surya Namaskar are holistic, need lesser time & money. In addition such protocols effect simultaneously, endurance, flexibility, strength, core stability, body ergonomics, mind, emotions & temperament. No separate practices are needed for each of these goals.
Grass Finishing Systems for Lambs

There is strong interest in sustainably produced meat. Grass-fed lamb could fulfill this market by reducing off-farm inputs. The objective was to examine the effect of grass-finishing or minimal supplementation on performance of lambs in the southeastern US. Katahdin lambs born in October 2013 and 2014 and February 2014 were weaned in January 2014/2015 and May 2014, respectively. Lambs were blocked by gender (fall; winter included only ram lambs) and randomly assigned to receive no (NON) or grain co-product supplement (SUP; 15% CP) at 0.5% of BW/d. Lambs were rotationally grazed on predominantly grass. Body weight, fecal egg counts (FEC), packed cell volume (PCV), and body condition score (2014 fall-born lambs only) were determined every 14 d. Winter lambs were removed from the study after 56 d due to poor performance. Live carcass composition was estimated by ultrasound on d 70 of study and when lambs reached light market weight. Data were analyzed by repeated measures in a mixed model. In the 2013 fall-born lambs, average daily gain (ADG) was greater for SUP than NON rams (184 ± 4.9 > 149 ± 5.5 g/d; P = 0.007), but did not differ among ewes (118 vs. 113 ± 5.2 g/d, respectively). The ADG of winter lambs was greater for SUP than NON (44 > 11 ± 9.5 g/d; P = 0.02). The ADG did not differ among treatments in 2014 fall lambs. The FEC tended to be lower in SUP than NON (P < 0.06) in fall 2013 lambs, but PCV was not different. The FEC of winter-born lambs and 2014 fall lambs was similar between treatments, but PCV was increased in SUP compared with NON lambs (27.0 > 25.5 ± 0.4%; P = 0.015; 29.0 > 27.8 ± 0.3%, P = 0.019). Modest supplementation can lead to greater gains and improved tolerance to gastrointestinal parasites for fall-born ram lambs when forage quality is limiting, and high quality forage can result in good weight gain without supplementation in these lambs. Winter or spring-born lambs may not be suitable for a grass-finished system in the southeastern US under these conditions.
Flagellin and multidrug resistance mutants as future Salmonella vaccines for laying hens

Sinds 1990 is Salmonella enterica subspecies enterica serovar Enteritidis een pandemisch pathogeen, aanwezig in landen met industriele pluimveeproductie. Inname van deze voedsel- geassocieerde pathogeen door de mens veroorzaakt gastro-enteritis en wordt gelinkt aan besmette eieren en ei-producten. Salmonellose veroorzaakt door Salmonella enteritidis in kippen leidt echter niet tot klinische symptomen maar zorgt voor zware economische verliezen. Zodoende is er voortdurende interesse om mogelijke manieren te vinden om leghennen te beschermen tegen infectie met Salmonella. De controle van deze Salmonella infecties in pluimveebedrijven begint met een goed management en strikte veiligheidsmaatregelen. Bij leghennen is vaccinatie een zeer belangrijke maatregel om besmetting te voorkomen. Hoewel er dankzij vaccinatie grote vorderingen gemaakt zijn, duiken er toch atypische pathogene Salmonella stammen op. Studies uit verschillende landen tonen het snel opkomen van een monofasische variant van Salmonella Typhimurium, ie 1,4,[5],12:i:-. Bijgevolg werd deze stam geincludeerd in acties die de controle en detectie van Salmonella serovars, gevaarlijk voor de volksgezondheid, omschrijven. In deze thesis werd nagegaan of de Salmonella Typhimurium stam Nal2/Rif9/Rtt, die aanwezig is in de commercieel beschikbare levende vaccins AviPro® Salmonella Duo en AviPro® Salmonella VacT ook bescherming biedt tegen deze monofasische variant.
Does Moral Intelligence Affects Corporate Social Responsibility Disclosures? A Field Study of the Financial Statements Preparers in the Jordanian Industrial Sector.

Exploring how the degree of corporate social responsibility (CSR) disclosure among Jordanian industrial firms is affected by fiscal statement arrangers’ moral intelligence is this research’s aim. It was anticipated that the higher extent of financial statements’ CSR disclosures is correlated to fiscal statement arrangers’ greater moral intelligence. Overall, the process of preparing fiscal reports and the level of CSR disclosure were found to be positively correlated to a greater degree of moral intelligence, thus confirming the research hypotheses.
Adaptively Biased OFDM for IM/DD-Aided Optical Wireless Communication Systems

In direct-current biased optical orthogonal frequency division multiplexing (DCO-OFDM), a constant DC bias is introduced to render the bipolar signal non-negative. However, due to the inherent disadvantage of high peak-to-average power ratio (PAPR), the DC bias should be set to a relatively high level to suppress the clipping distortion, resulting in power inefficiency. Therefore, we conceive a novel adaptively biased optical OFDM (ABO-OFDM) for optical wireless communication (OWC), where the bias is dynamically optimized according to the signal magnitude to enhance the power efficiency. Meanwhile, the interference induced by the adaptive bias is placed on the reserved subcarriers, which avoids contaminating the legitimately transmitted information data. The implementation complexity of the ABO-OFDM transceiver is almost the same as asymmetrically clipped optical OFDM (ACO-OFDM), which is notably lower than the superimposed OFDM schemes. Numerical results have demonstrated that the proposed ABO-OFDM outperforms the conventional DCO-OFDM and ACO-OFDM in terms of power efficiency.
Change of spatial distribution in the ichiotocenosis of the shabolat estuary in the process of its anthropogenic transformation

Consequences of Shabolat estuary natural ecosystems transformation under the influence of anthropogenic factors are reflected in the composition of ichthyocenosis, changes in the basic population characteristics of the most mass species.The purpose of the work was to find out the spatial distribution of the Shabolat estuary most massive representatives of the ichthyocenosis in terms of its anthropogenic transformation.Material and methods. The material for the study was selected from industrial fishing gear in the spring, summer and autumn periods of 2009-2012. A complete biological analysis of fish (goby round, goby grass, flounder, flounder, mullet pilengas, etc.) was carried out according to the conventional method.Result. The regularities of formation of ichthyocenosis largest masses populations were studied depending on: water salinity, connection with adjacent water areas, fish acclimatization and introduction, anthropogenic loading and peculiarities of spatial distribution of ichthyocenosis largest masses populations in aquatics.The most important Shabolat estuary ichthyocomplex components include representatives of the Gobiidae family, the Platichthys luscus population and the mullet family representatives.Of particular interest to the members of the goby family are the mass species of gobies: the round goby Neogobius melanostomus and the grass goby Zosterisessor ophiocephalus, which are able to hibernate and reproduce in the estuary. This is an important link in the food chains of the reservoir. By entering into competition with other representatives of ichthyocenosis, they significantly affect the state of the forage base and production capacity of the estuary.Representatives of the mullet family and gloss flounder are distributed in the estuary deep water areas and in areas with maximum salinity.Conclusions. It has been established, that in the conditions of anthropogenic transformation of the estuary, in the last 35-40 years, the round goby and grass goby numbers and distribution range have decreased. In bulk, they have survived only in reservoir small, local areas, due to the deterioration of reproduction conditions and the degradation of the zoster and reddest associations. The main reasons for the decline in the size and distribution range of gobies in the Shabolatsky estuary was their mass death as a result of a large-scale environmental catastrophe and reproduction conditions deterioration. The reason for the significant decrease in the flounder and mullet number and distribution range was the mass death in 1992, as well as changes in the salinity of the Shabolat estuary
Increased MSX level improves biological productivity and production stability in multiple recombinant GS CHO cell lines

Increasing cell culture productivity of recombinant proteins via process improvements is the primary focus for research groups within biologics manufacturing. Any recommendations to improve a manufacturing process obviously must be effective, but also be robust, scalable, and with product quality comparable to the original process. In this study, we report that three different GS−/− CHO cell lines developed in media containing a standard concentration of the selection agent methionine sulfoximine (MSX), but then exposed to increased MSX concentrations during seed train expansion, achieved titer increases of 10–19%. This result was observed in processes already considerably optimized. Expanding the cells with a higher MSX concentration improved cell line production stability with increased culture age. Production cultures in 500‐L and 1000‐L bioreactors replicated laboratory results using 5‐L bioreactors, demonstrating process robustness and scalability. Furthermore, product quality attributes of the final drug substance using the higher MSX process were comparable with those from cells expanded in media with the standard selection MSX concentration. Subsequent mechanistic investigations confirmed that the cells were not altered at the genetic level in terms of integration profiles or gene copy number, nor transcriptional levels of glutamine synthetase, heavy chain, or light chain genes. This study provides an effective and applicable strategy to improve the productivity of therapeutic proteins for biologics manufacturing.
Urgency and ambition: the influence of political environment and emotion in spurring US women’s candidacies in 2018

This article analyses publicly reported statements of motivation by non-incumbent women US House candidates in 2018 to assess the role of negative emotions, particularly those cued by catalysing events like the 2016 presidential election, in women candidate emergence. Findings reveal that Democratic non-incumbent women candidates were most likely to describe negative inducements, including feelings of urgency, anger and/or threat, as motivating candidacy, with these emotions slightly more evident in white women’s statements. This indicates that women’s candidacies can emerge, at least in part, from perceptions that the costs of not running are too high to stay on the sidelines.
Alimentation d’un Moteur Asynchrone à partir d’un Générateur Photovoltaïque

Photovoltaic solar energy is considered among the most exploited renewable energies in the world and more specifically in Algeria, especially in Adrar region, either on a public scale (7 photovoltaic plants deliver 53 MW) or on personal one represented by its vast use in irrigation. The aim of this work is the performance evaluation of a photovoltaic generator under different climatic conditions (temperature and irradiation) and when connected with an asynchronous motor. This photovoltaic system comprises a DC-DC converter controlled by MPPT P&O and a two-level inverter controlled by the STPWM technique.