Miracle-dz/UniFAR-FTUs huggingface dataset:
Changes in Faecal Microbiota Profiles Associated With Performance and Birthweight of Piglets

The gastrointestinal tract microbiota interacts with the host to modulate metabolic phenotype. This interaction could provide insights into why some low birthweight pigs can exhibit compensatory growth whilst others remain stunted. This study aimed to identify microbiota markers associated with birthweight [low birthweight (n = 13) or normal birthweight pigs (n = 13)] and performance [“good” or “poor” average daily gain (ADG) class]. Furthermore, the study determined whether the taxonomic markers were longitudinal, or time point specific in their ability to identify low birthweight pigs who could exhibit compensatory growth. Faecal samples were collected and liveweight recorded at 10 different time points from birth to 56 days of age. No consistent associations between birthweight, performance and gut microbiota were found across all time points. However, there was a significant (P < 0.05) effect of birthweight on microbiota richness at 21, 27, 32 and 56 days of age. Significant differences (P < 0.05) in genera abundance according to birthweight and performance were also identified. Low birthweight pigs had a significantly (P < 0.05) lower abundance of Ruminococcaceae UCG-005, but a significantly (P < 0.05) higher abundance of Ruminococcaceae UCG-014 on days 21 and 32, respectively. Piglets classified as having a “good” ADG class had a significantly (P < 0.05) higher abundance of Lactobacillus, unclassified Prevotellaceae and Ruminococcaceae UCG-005 on days 4, 8 and 14, respectively. Furthermore, Ruminococcaceae UCG-005 was significantly more abundant at 14 days of age in normal birthweight pigs with a “good” ADG class compared to those classified as “poor. ” The results of this study indicate that there are time point-specific differences in the microbiota associated with birthweight and performance, corresponding to the period in which solid feed intake first occurs. Identifying early-life microbiota markers associated with performance emphasises the importance of the neonatal phase when considering intervention strategies aimed at promoting performance.
New Food Crop Domestication in the Age of Gene Editing: Genetic, Agronomic and Cultural Change Remain Co-evolutionarily Entangled

The classic domestication scenario for grains and fruits has been portrayed as the lucky fixation of major-effect “domestication genes. ” Characterization of these genes plus recent improvements in generating novel alleles (e.g., by gene editing) have created great interest in de novo domestication of new crops from wild species. While new gene editing technologies may accelerate some genetic aspects of domestication, we caution that de novo domestication should be understood as an iterative process rather than a singular event. Changes in human social preferences and relationships and ongoing agronomic innovation, along with broad genetic changes, may be foundational. Allele frequency changes at many loci controlling quantitative traits not normally included in the domestication syndrome may be required to achieve sufficient yield, quality, defense, and broad adaptation. The environments, practices and tools developed and maintained by farmers and researchers over generations contribute to crop yield and success, yet those may not be appropriate for new crops without a history of agronomy. New crops must compete with crops that benefit from long-standing participation in human cultural evolution; adoption of new crops may require accelerating the evolution of new crops’ culinary and cultural significance, the emergence of markets and trade, and the formation and support of agricultural and scholarly institutions. We provide a practical framework that highlights and integrates these genetic, agronomic, and cultural drivers of change to conceptualize de novo domestication for communities of new crop domesticators, growers and consumers. Major gene-focused domestication may be valuable in creating allele variants that are critical to domestication but will not alone result in widespread and ongoing cultivation of new crops. Gene editing does not bypass or diminish the need for classical breeding, ethnobotanical and horticultural knowledge, local agronomy and crop protection research and extension, farmer participation, and social and cultural research and outreach. To realize the ecological and social benefits that a new era of de novo domestication could offer, we call on funding agencies, proposal reviewers and authors, and research communities to value and support these disciplines and approaches as essential to the success of the breakthroughs that are expected from gene editing techniques.
Genes for rust resistance in International Winter Wheat Nurseries XII through XVII

Genes for resistance to stem rust (Sr) (caused by Puccinia graminis Pers.:Pers. f. sp. tritici) and leaf rust (Lr) (P. recondita Roberge ex. Desmaz f. sp. tritici) were detected in cultivars of wheat (Triticum aestivum L.) of the International Winter Wheat Performance Nursery XII through XVII. The objectives were to test for the presence and distribution of Sr and Lr genes. Entries were inoculated with 28 isolates of P. graminis f. sp. tritici and 15 isolates of P. recondita f. sp. tritici, previously characterized for avirulence/virulence to 26 Sr and 14 Lr genes, respectively (.)
Effect of Qualitative Feed Restriction in Broiler Breeder Pullets on Stress and Clinical Welfare Indicators

The feed restriction applied during rearing of broiler breeders inflicts chronic hunger, and frustration due to unfulfilled behavioural needs for feeding. To alleviate the welfare problems associated with feed restriction, qualitative feed restriction allows a larger amount of feed to be provided without increasing the energy intake. In the present study, the aim was to investigate the effect of scatter-fed qualitative feed restriction on a range of welfare indicators in broiler breeders at the end of the rearing period. In total, 1,200 female breeder chicks of the genotype Ross 308 were housed in 24 pens: six pens of initially 50 birds per dietary treatment. The treatments were: (1) standard feed (Control), (2) standard feed diluted with oat hulls (Insoluble), (3) standard feed diluted with oat hulls and sugar beet pulp (Mixed), and (4) standard feed plus maize silage (Roughage). At 15 weeks of age, a blood sample was taken from 40 birds (10/treatment) five times within 24 h. The plasma was analysed for corticosterone concentration. At 19 weeks of age, a clinical welfare assessment was performed on all birds before they were sacrificed. From each bird, three feathers were plucked and macroscopically examined for the presence of fault bars. Feather length and weight were also recorded. Mortality was registered on occurrence throughout the rearing period. Treatment affected the plumage condition, footpad dermatitis, plumage dirtiness, vent pasting, and number of severe fault bars (P ≤ 0.05) but not plasma corticosterone concentration, hock burns, hyperkeratosis and mortality (P ≥ 0.17). There was an effect of the interactions between treatment and feather type on the total number of fault bars per feather, average position of the fault bars relative to the base of the feather, and growth rates of feather mass and length (P < 0.0001). Overall, the results showed improved welfare of Roughage birds and reduced welfare of Mixed birds, whereas the welfare of Insoluble birds did not seem to differ noticeably from that of Control birds. We recommend to further develop a feeding strategy that includes daily allocation of roughage to broiler breeders during the rearing period.
Smoking Prevalence, Patterns, and Cessation Among Adults in Hebei Province, Central China: Implications From China National Health Survey (CNHS)

As part of the China National Health Survey, the objective of this study was to explore the prevalence, patterns, and influencing factors of smoking, and understand reasons for smoking cessation among adults in Hebei Province, central China. Using a multi-stage stratified cluster sampling method, 6,552 adults (2,594 males) aged 20–80 were selected in 2017. Demographic, socioeconomic, and tobacco use information were collected by questionnaire interview. The prevalence of ever-smoking, current smoking, and ex-smoking was 28.94, 21.08, and 7.86%, respectively. Male participants had a much higher prevalence of ever-smoking and current smoking (67.39 and 48.77%) than females (3.74 and 2.93%). In male participants, the daily cigarette consumption was 16.61, and the mean age of smoking initiation was 20.95, decreasing with birth year (27.50 in people born before 1946 vs. 17.9 for those born after 1985, p for trend < 0.001). Over 40% of male ever-smokers initiated regular smoking before 20. Compared with never drinking, the ORs (95% CI) of ever-smoking for low, moderate, and high alcohol consumption in male participants were 1.44 (1.11–1.86), 2.80 (1.91–4.11), and 2.40 (1.72–3.33), respectively. Among 479 male ex-smokers, 50.94% stopped smoking because of illness and 49.06% by choice. Among male ex-smokers, hypertensive men were more likely to quit smoking than the normotensive individuals (OR: 1.48, 95% CI: 1.13–1.96). For CVD patients, this effect was estimated as 2.27 (95% CI: 1.56–3.30). This study revealed a high prevalence of ever-smoking, especially in men, in a representative population in central China. Health education focus on tobacco control could be integrated with alcohol consumption reduction to achieve additional benefit.
The Profiles of Non-stationarity and Non-linearity in the Time Series of Resting-State Brain Networks

The linearity and stationarity of fMRI time series need to be understood due to their important roles in the choice of approach for brain network analysis. In this paper, we investigated the stationarity and linearity of resting-state fMRI (rs-fMRI) time-series data from the Midnight Scan Club datasets. The degree of stationarity (DS) and the degree of non-linearity (DN) were, respectively, estimated for the time series of all gray matter voxels. The similarity and difference between the DS and DN were assessed in terms of voxels and intrinsic brain networks, including the visual network, somatomotor network, dorsal attention network, ventral attention network, limbic network, frontoparietal network, and default-mode network. The test-retest scans were utilized to quantify the reliability of DS and DN. We found that DS and DN maps had overlapping spatial distribution. Meanwhile, the probability density estimate function of DS had a long tail, and that of DN had a more normal distribution. Specifically, stronger DS was present in the somatomotor, limbic, and ventral attention networks compared to other networks, and stronger DN was found in the somatomotor, visual, limbic, ventral attention, and default-mode networks. The percentage of overlapping voxels between DS and DN in different networks demonstrated a decreasing trend in the order default mode, ventral attention, somatomotor, frontoparietal, dorsal attention, visual, and limbic. Furthermore, the ICC values of DS were higher than those of DN. Our results suggest that different functional networks have distinct properties of non-stationarity and non-linearity owing to the complexity of rs-fMRI time series. Thus, caution should be taken when analyzing fMRI data (both resting-state and task-activation) using simplified models.
Clinical, dietary, and psychosocial effectiveness of interdisciplinary care in child and juvenile obesity

Introduction:Obesity in the pediatric population is defined as body mass index above the 97th percentile of the body mass index/Center for Disease Control and Prevention and is considered an important problem in public health with severe short-and long-term consequences for individuals, their families, and society. The aim of this study is to evaluate the effectiveness of interdisciplinary care in modifying anthropometric clinical parameters, psychosocial profile and eating behavior in a group of children and adolescents with obesity. Materials and Methods:This is a clinical study involving 200 children and adolescents with obesity who are participants of the Preventive Medicine Service program, and the Center for Medical Specialties of Children and Adolescents both in Aracaju, Sergipe, Brazil. Results and Discussion: At the end of the interdisciplinary intervention, there was a decrease in the number of hours devoted to electronic games and television and an increase in physical activity, which was associated with a reduction in reports of dissatisfaction and symptoms of depression. In addition, the sadness and prejudice related to obesity suffered at school and in the family environment were also attenuated, despite the percentage increase in the anxiety indicator. Regarding the anthropometric measurement, there was a reduction in body mass index, waist circumference, in caloric consumption. It is concluded that interdisciplinary programs are an effective strategy to reduce the negative repercussions of obesity in the daily lives of obese children and adolescents, as there were improvements in anthropometric parameters, in addition to psychosocial and dietary aspects.
A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations

Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ) are the downstream effectors of the Hippo signaling pathway that play a crucial role in various aspects of cancer progression including metastasis. Metastasis is the multistep process of disseminating cancer cells in a body and responsible for the majority of cancer-related death. Emerging evidence has shown that cancer cells reprogram their metabolism to gain proliferation, invasion, migration, and anti-apoptotic abilities and adapt to various environment during metastasis. Moreover, it has increasingly been recognized that YAP/TAZ regulates cellular metabolism that is associated with the phenotypic changes, and recent studies suggest that the YAP/TAZ-mediated metabolic alterations contribute to metastasis. In this review, we will introduce the latest knowledge of YAP/TAZ regulation and function in cancer metastasis and metabolism, and discuss possible links between the YAP/TAZ-mediated metabolic reprogramming and metastasis.
Antenatal Care Initiation Among Pregnant Women in the United Arab Emirates: The Mutaba'ah Study

Introduction: Antenatal care (ANC) provides monitoring and regular follow-up of maternal and fetal health during pregnancy. Women with appropriate ANC tend to have better delivery and birth outcomes. This study describes the patterns of ANC utilization and factors associated with appropriate ANC initiation in the United Arab Emirates (UAE) for the first time. Methods: Baseline cross-sectional data from pregnant women who participated in the Mutaba'ah—Mother and Child Health Study between May 2017 and January 2019 was analyzed. Participants were recruited during ANC visits and completed a self-administered questionnaire that collected socio-demographic and pregnancy-related information and assessed whether it was their first ANC appointment. Regression models assessed the relationship between socio-demographic and pregnancy-related variables and “appropriate” (≤ 4 months' gestation) vs. “late” ANC initiation (>4 months' gestation). Results: At recruitment, 841 participants reported that it was their first ANC visit and half (50.2%) of these women were late initiating their ANC. Mothers who were more educated, had previous infertility treatment or previous miscarriages were all more likely to achieve appropriate ANC initiation [adjusted odds ratio (aOR): 1.66, 95% confidence interval (CI): 1.05–2.62; aOR: 3.68, 95% CI: 1.50–9.04; aOR: 1.80, 95% CI: 1.16–2.79, respectively]. Women worrying about childbirth were less likely to achieve appropriate ANC initiation (aOR: 0.54, 95% CI: 0.34–0.85). Conclusion: Half of pregnant women in this study did not achieve the global consensus guidelines on appropriate ANC initiation. Interventions among less educated women and those with previous pregnancy complications and childbirth anxiety are recommended to ensure appropriate ANC initiation.
Agonistic and Sexual Display in Aquatic and Semi-Terrestrial Brachyuran Grabs

Behavioral patterns of inter-crab communications as shown in agonistic and sexual interactions are investigated in 26 genera within 9 aquatic and semi-terrestrial families of brachyurans. The investigation includes a review of literature and the author's observations. Species of the aquatic families, Dromiidae, Leucosiidae, Majidae, Parthenopidae, Cancridae, Portunidae, and Xanthidae, display agonistic activities mostly with more or less extended chelipeds. An encounter leads often to physical interactions, such as striking blows or grasping with chelae. Many of the semi-terrestrial ocypodids and grapsids, however, display with flexed chelipeds, showing the opponent the outer side of the chelae in a shield-like manner. Encounters usually follow a formalized set of patterns and only occasionally do they lead into a “wild fight”. Concerning sexual activities in many aquatic forms, a male catches and holds or cages a female between its legs for several days during the mating period. In many semi-terrestrial grapsids and ocypodids, patterns of up-down display of chelipeds have been observed during agonistic encounters, as well as during initial stages of mating. In other forms a special display of chelipeds occurs in courtship. In agonistic and sexual activities of aquatic forms intern-crab communication seems to depend mainly on tactile and possibly chemical stimuli. In the semi-terrestrial forms that have been investigated, mechanisms of communication are based predominantly on optical information.
Inhibitory effects of ursolic acid derivatives from Cynomorium songaricum, and related triterpenes on human immunodeficiency viral protease

From the stems of Cynomorium songaricum Rupr. (Cynomoriaceae), ursolic acid and its hydrogen malonate were isolated as inhibitory substances against human immunodeficiency virus (HIV‐1) protease. Their 50% inhibitory concentrations (IC50) were 8 μM and 6 μM, respectively. Of various dicarboxylic acid hemiesters of related triterpenes synthesized, the inhibitory activities tended to increase in the order of oxalic, malonyl, succinyl and glutaryl hemiesters of triterpenes such as ursolic acid, oleanolic acid and betulinic acid. The most potent inhibition was observed for the glutaryl hemiesters with IC50 of 4 μM. © 1998 John Wiley & Sons, Ltd.
Distinguishing Seedlings of Pines of Piedmont Upland Grassland Systems

ABSTRACT Despite the ecological and economic importance of pines (Pinus) in the southeastern United States, there exist no taxonomic keys or resources that facilitate the comprehensive identification of pine seedlings. The objectives of this study were to analyze select aspects of seedling morphology for the three primary pines associated with Piedmont upland grassland systems of conservation concern (Pinus echinata, P. taeda, and P. virginiana) and subsequently to develop a resource, traditional or probabilistic, depending on the outcome, to facilitate species-level determination. Two characters—the number of primary needles in the first whorl post-germination and needle apical curvature relative to the stem—were assessed through analysis of 3,200 seedlings under field conditions. The mean number of primary needles in the first whorl was 5.9 (s.d.=0.56) for P. echinata, 7.3 (s.d.= 0.79) for P. taeda, and 5.3 (s.d.=0.63) for P. virginiana. Predominant needle apical curvature was away from the stem in P. echinata (90.5%) and P. virginiana (91.5%), but toward the stem in P. taeda (97.5%). Based on these data, a probabilistic diagnostic framework that takes into consideration both morphology and stand composition is presented, including supplemental appendices of calculated posterior probabilities.
Trichodinids (Ciliophora, Peritrichia) Of Perccottus Glenii (Actinopterygii, Odontobutidae) In Three Ukrainian Rivers

Abstract Trichodinids (Ciliophora, Peritrichia) of Perccottus glenii (Actinopterygii, Odontobutidae) in Three Ukrainian Rivers. Drobiniak, O. , Kutsokon, Yu. , Kvach, Yu. — The Chinese sleeper Perccottus glenii Dybowski, 1877 (Actinopterygii, Odontobutidae), alien for Ukrainian rivers, was examined for presence of trichodinids (Ciliopora, Peritrichia). Six species belonging to the genus Trichodina were found: Trichodina acuta Lom, 1961; T. intermedia Lom, 1961; T. mutabilis Kazubski et Migala, 1968; T. nigra Lom, 1960; T. pediculus Ehrenberg, 1838; T. perforata Lom, Golemansky et Grupcheva, 1976. For the first time for Chinese slipper, T. perforata and T. intermedia were recorded. Morphometric data of all found species were compared with those from previous descriptions.
Altered Composition of Gut Microbiota in Depression: A Systematic Review

Cumulative evidence shows a linkage between gut microbiota pattern and depression through the brain-gut microbiome axis. The aim of this systematic review was to identify the alterations of the gut microbiota patterns in people with depression compared to healthy controls. A comprehensive literature search of human studies, published between January 2000 and June 2019, was reviewed. The key words included gastrointestinal microbiome, gut microbiome, microbiota, depression, depressive symptoms, and depressive disorder. The systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Nine articles met the eligibility criteria. Disparities in α-diversity and β-diversity of the microbiota existed in people with depression compared to healthy controls. At the phylum level, there were inconsistencies in the abundance of Firmicutes, Bacteroidetes, and Proteobacteria. However, high abundance in Actinobacteria and Fusobacteria phyla were observed in people with depression. On the family level, high abundance of Actinomycineae, Coriobacterineae, Bifidobacteriaceae, Clostridiales incertae sedis XI, Porphyromonadaceae, Clostridiaceae, Lactobacillaceae, Streptococcaceae, Eubacteriaceae, Thermoanaerobacteriaceae, Fusobacteriaceae, Nocardiaceae, Streptomycetaceae, and low abundance of Veillonellaceae, Prevotellaceae, Bacteroidaceae, Sutterellaceae, Oscillospiraceae, Marniabilaceae, and Chitinophagaceae were observed in people with depression. On the genus level, high abundance of Oscillibacter, Blautia, Holdemania, Clostridium XIX, Anaerostipes, Anaerofilum, Streptococcus, Gelria, Turicibacter, Parabacteroides, Eggerthella, Klebsiella, Paraprevotella, Veillonella, Clostridium IV, Erysipelotrichaceae incertae sedis, Eubacterium, Parvimonas, Desulfovibrio, Parasutterella, Actinomyces, Asaccharobacter, Atopobium, Olsenella and low abundance of Coprococcus, Lactobacillus, Escherichia/Shigella, Clostridium XlVa, Dialister, Howardella, Pyramidobacter, and Sutterella were found in people with depression. Alteration of gut microbiome patterns was evident in people with depression. Further evidence is warranted to allow for the translation of microbiome findings toward innovative clinical strategies that may improve treatment outcomes in people with depression.