Miracle-dz/UniFAR-FTUs huggingface dataset:
Hallazgo de diclofenaco en un producto fitoterapéutico a base de caléndula comercializado en Colombia

Introducción: la consulta de un particular que trajo un producto fitoterapéutico a base de caléndula cuyo consumo le causó fuertes reacciones adversas, originó esta investigación sobre la composición de este producto. Objetivo: caracterizar la composición química de muestras de lotes diferentes de un producto comercial denominado fitoterapéutico a base de caléndula (Calendula officinalis) (PFC) comercializado en Colombia. Metodología: se analizaron tabletas de ocho cajas del PFC de cuatro lotes diferentes de producción (2017 y 2018). Se llevó a cabo el análisis de espacio de cabeza (HS) de tabletas por microextracción en fase sólida (SPME), con una fibra PDMS/DVB (65 μm), expuesta al HS de la muestra durante 30 min a 50 °C. Las fracciones volátiles se analizaron por cromatografía de gases acoplada a espectrometría de masas (GC/MS). Los extractos de tabletas obtenidos con mezcla de metanol:agua (1:1, v/v) se analizaron por cromatografía líquida (LC) de alta (HPLC) y ultra-alta eficiencia (UHPLC), con detectores de arreglo de diodos (DAD) y espectrometría de masas de alta resolución (HRMS), respectivamente; la cuantificación de diclofenaco se hizo por calibración con patrón externo y poradición de estándar. Los espectros de masas de baja y alta resolución y patrones de fragmentación de las sustancias detectadas se estudiaron, usando GC/HRMS y LC/HRMS-Orbitrap. Resultados: en tabletas analizadas por HS-SPME, se encontraron monoterpenoides y sesquiterpenoides de origen vegetal, ftalatos, residuos de solventes (2-cloroetanol, etilenglicol) y sustancias químicas intermediarias en la síntesis de diclofenaco (2,6-dicloroanilina y 2,6-cloro-N-fenil-bencenamina). En los cromatogramas, obtenidos por GC/MS de los extractos de tabletas obtenidos con diclorometano, se detectaron diclofenaco, sus impurezas A, B y C, los ésteres de diclofenaco y algunas otras impurezas. Diclofenaco en cantidad ca. 40 mg (7-8%) se cuantificó por HPLC en tabletas (> 70 analizadas) escogidas al azar de ocho cajas del PFC, adquirido en el mercado local de Bucaramanga (Colombia). Conclusión: en cada tableta analizada se determinaron alrededor de 40 mg del compuesto sintético diclofenaco (sustancia no declarada en la etiqueta del producto) y en ninguna se detectaron ésteres de los triterpenoides oleanano o faradiol, constituyentes del extracto de caléndula que poseen actividad antiinflamatoria; se encontraron algunos flavonoides comunes a muchas plantas, en cantidades mil veces menores que la de diclofenaco.
Validation-free offchain transactions with unlinkable double spend detection

spender and not trace other transactions. This scheme is based on the anonymous transferable e-cash system. We use an oﬀchain analogue of the UTXO model, therefore there are oﬀchain transactions for issue, transfer and redeem of a so-called note, containing a number that can be used as a secret key to make the corresponding token transfer transaction onchain.
Análise configuracional das proximidades em alianças de inovação

RESUMO As alianças tornaram-se fator crítico para o desenvolvimento da inovação, contudo a falta de proximidade entre os parceiros, que vai além do aspecto geográfico, pode influenciar os resultados. Apesar desse entendimento, os estudos não avaliam a inter-relação das proximidades em alianças de inovação. Esta pesquisa busca compreender quais combinações de proximidades levam a alianças exploration e exploitation. Para perscrutar esse caminho, realizou-se um survey com 174 empresas de alta tecnologia; como método, adotou-se a Análise Qualitativa Comparativa (QCA). Os resultados encontrados destacam que, no contexto de parceiros próximos fisicamente, as alianças de exploration são dependentes de proximidade social, combinadas com proximidade cognitiva ou institucional. Já as alianças exploitation são dependentes de proximidades cognitiva e social, somada à ausência de proximidade organizacional. Tem-se como conclusão que a orientação inovadora das alianças não depende do desenvolvimento de todas as dimensões de proximidade e destaca-se, assim, a relevância dos laços sociais.
Association Between Z Drugs Use and Risk of Cognitive Impairment in Older Patients With Chronic Insomnia

Background Benzodiazepines (BZDs) and Z drugs are widely used for patients with chronic insomnia. The long term use of BZDs in older patients can cause cognitive impairment and potentially increase the risk of dementia. However, evidence for an association with Z drugs is limited. This study aimed to investigate the association between the risk of cognitive impairment and exposure to Z drugs in older patients with chronic insomnia.Methods We recorded older patients with chronic insomnia who visited the outpatient department of neurology, Beijing Friendship Hospital, and assessed the global cognitive function (MoCA) and five cognitive domains (CVLT, TMT-B, BNT-30, CDT and DST). Multiple regression analysis was conducted to determine the independent factors of cognition, and evaluate the effect of Z drugs use (zolpidem and zopiclone) on cognition.Results A total of 88 subjects were identified. BZDs use (P=0.03, B=2.67, 95% CI 0.36-4.97) and BZDs exposure density (P=0.01, B=1.22, 95% CI 0.33-2.11) were independent risk factors of cognitive impairment in older patients with chronic insomnia. Neither Z drugs use (P=0.11) nor Z drugs exposure density (P=0.92) correlated with global cognitive function. Moreover, compared with BZDs users, there were positive associations between Z drugs use and memory (P=0.00), attention (P=0.00) and verbal function (P=0.04). Additionlly, education level (P=0.02, OR=0.74, 95% CI 0.57-0.95), duration of insomnia (P=0.04, OR=1.05, 95% CI 1.00-1.11) and severity of insomnia (P=0.03, OR=1.27, 95% CI 1.02-1.57) were also independent factors of global cognitive function.Conclusion We found no evidence that Z drugs use and Z drugs exposure density were associated with cognitive impairment in older patients with chronic insomnia. However, the use of BZDs and BZDs exposure density were associated with an increased risk of cognitive impairment. Thus, BZDs use should be avoided，and Z drugs should be prescribed with extreme caution in the elderly.
Beyond Dualism

Chapter 11 is devoted to Benamozegh’s presentation of Kabbalah as a vehicle for understanding and achieving religious unity and progress. His use of kabbalistic hermeneutics, predicated on the key concepts of coincidence of opposites, of berur (clarification) and of illuy (elevation), aimed (a) to suspend commonly held binaries such as science and faith, East and West, worldliness and transcendence, and (b) to prove Kabbalah’s affinity with nineteenth-century conceptions of assimilation and of progress.
Peripheral Uric Acid as a Biomarker in Individuals With Bipolar Disorder: A Case Control Study

Background: At present, no well-established biomarkers were ever found to distinguish unipolar disorder (UD) and bipolar disorder (BD). This study aimed to explore whether uric acid (UA) could be a biomarker to distinguish UD and BD. Methods: Peripheral UA of 119 patients with BD in acute stage (AS) and 77 in remission stage (RS), and 95 patients with UD in AS and 61 in RS were measured, so were 180 healthy controls. Differences in continuous variables among groups were assessed by the independent samples t-test and one-way analysis of variance. The chi-square test was applied to categorical data such as gender. Results: UA levels in BD group were higher than UD and HC groups regardless of the AS or RS, while differences in UA levels between UD group and HC group were not significant. Differences of UA levels between BD-M (bipolar mania/hypomania) and BD-D (bipolar depression) subgroups were not significant, and UA levels of BD-M and BD-D subgroups were higher than UD and HC groups. Only in UD group, UA levels of drug-use subgroup were higher than drug-naïve/free subgroup, but differences disappeared when analyzed stratified by sex; whether in drug-use or drug-naïve/free subgroup, differences of UA levels between BD-M and BD-D groups were not significant.Conclusion: The study suggests UA levels may be a biomarker of BD to distinguish from UD.
1T-Phase MoS2 Nanosheets on TiO2 Nanorod Arrays: 3D Photoanode with Extraordinary Catalytic Performance

A novel three-dimensional (3D) photoanode with exfoliated MoS2 nanosheets on TiO2 nanorod arrays (TiO2 NAs) was successfully fabricated by combining hydrothermal and drop-casting methods. The influences of the different phases (1T and 2H) of the MoS2 nanosheets on the photoelectrochemical (PEC) performances of such a TiO2 NAs/MoS2 3D system have been systematically investigated. Parallel experiments revealed that the TiO2 NAs/1T-MoS2 composite with optimized 1T-MoS2 loading exhibited the highest photoelectric conversion efficiency, which was about 440 and 93% higher than those of the TiO2 NAs and the TiO2 NAs/2H-MoS2 counterpart, respectively. The enhanced catalytic performances of the TiO2 NAs/1T-MoS2 composite can be attributed to the superior conductivity of 1T-MoS2 and the strong interaction between TiO2 NAs and 1T-MoS2. The photogenerated holes can therefore transfer from the TiO2 NAs to the 1T-MoS2, thus leading to enhanced charge separation efficiency.
CHROMATOGRAPHIC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF STIGMASTEROL AND EMBELIN

Standardization of herbal formulation is essential in order to assess the quality, purity, safety and efficacy of drugs. The present work describes a chromatographic method for simultaneous estimation of stigmasterol and embelin which can be further applied for standardization of chopchinyadi churna. Chopchinyadi churna is a polyherbal formulation prescribed for treatment of skin diseases. This preparation also works well in rheumatoid arthritis and gout. It contains Smilax china and Embelia ribes as major components in formulation from which stigmasterol and embelin respectively were used as marker compounds. A simple, rapid, precise, accurate, and reproducible High Performance Thin Layer Chromatographic (HPTLC) method was developed. The separation was performed on TLC aluminium plates precoated with silica gel 60 F254, wherein good separation was achieved in the mobile phase of Toluene: ethyl acetate: methanol: formic acid (6:2:1:1 v/v/v/v). Densitometric scanning for stigmasterol and embelin was done using single wavelength i.e 212nm. The retardation factor(Rf) value of stigmasterol and embelin was found to be 0.63+0.02 and 0.45+0.02, respectively. The developed method was validated as per ICH guidelines and applied for standardization of chopchinyadi churna from in-house and marketed formulations.
Biodegradable brush copolymer nanomicelles for smart release of doxorubicin

Background and objective: In cancer therapy, smart and biocompatible nanocarriers are the most important features of therapeutic agents. pH-sensitive drug delivery nanocarriers which can be remotely prompted are attractive for patients management and therapeutic purposes. In this paper, a novel nanocarrier was fabricated and investigated for controlled release of Doxorubicin (DOX). Materials and methods: Self-assembled nanomicelles containing a hydrophilic core and a hydrophobic shell were successfully prepared using poly(2-hydroxyethyl methacrylate-graft-e-caprolactone)-block-poly (methacrylic acid) [P(HEMA-g-CL)-b-(PMAAc)] brush copolymer by combining reversible addition-fragmentation chain transfer polymerization (RAFT) and ring open polymerization (ROP). Morphology, micelles properties, and pH-sensitive behavior were studied by field emission scanning electron microscopy (FESEM), transmission electron microscope (TEM) and distribution laser-scattering (DLS) analysis. Results and conclusion: Molecular weight of P(HEMA-g-CL) and [P(HEMA-g-CL)-b-PMAAc] samples was obtained as 15117 g mol-1 and 25887 g mol-1, respectively. The polydispersity index (PDI) of P(HEMA-g-CL) (PDI = 1.14) and [P(HEMA-g-CL)-b-PMAAc] (PDI = 1.19) synthesized byRAFT polymerization were relatively low, suggesting good control of the technique over the process. The self-assembled micelles were pH-sensitive and showed low critical concentration in water. TEM showed that the micelles had nanosized spherical shape with average size of 35 nm. The critical micelle concentration (CMC) value of [P(HEMA-g-CL)-b-PMAAc] micelle was 0.025 g l-1. Encapsulation efficacy of the nanomicelle was 94.3%. Release behavior of DOX from the nanomicelles revealed that rate of core release could be efficiently controlled by body temperature and pH. In this regard, the release rate at pH of 7.4 and 5.4 was 54.73% and 36.52%, respectively. As a conclusion, structure of the nanocarrier and its controllable characteristics introduced it as appropriate vehicle in drug delivery.
Synthesis and Property of 1,4-Diamino-3,6- dinitropyrazolo[4,3-c]pyrazole and Its Derivatives

A synthetic procedure has been developed for the synthesis of 1,4-diamino3,6-dinitropyrazolo[4,3-c]pyrazole (DADNP) via N-amination reaction. Its derivatives, 4,4’-(triaz-1-ene-1,3-diyl)bis(1-amine-3,6-dinitropyrazolo[4,3-c] pyrazole) (TBADNP) and 1,4-dinitramino-3,6-dinitropyrazolo[4,3-c]pyrazole (DNADNP), were first designed and synthesized by the diazotization and nitrification of amino group, and their structures were characterized by IR, 1H NMR, 13C NMR, elementary analysis and MS. The thermal properties of target compounds were studied by means of differential scanning calorimetry (DSC) and thermogravimetry (TG). The thermal decomposition peak temperatures of DADNP, TBADNP and DNADNP are 227, 236 and 288 °C, respectively. Results show that the derivatives of 1,4-diamino-3,6-dinitropyrazolo[4,3-c]pyrazole have better thermal stability.
Effect of Organic Loading Rate on Anaerobic Digestion of Food Waste under Mesophilic and Thermophilic Conditions

This study investigated the effect of organic loading rate (OLR) on anaerobic digestion (AD) of food waste under mesophilic and thermophilic conditions. Results showed that the performance of the AD system was distinctly influenced by temperature and OLR in terms of biogas production, intermediate metabolism, and degradation performance. The optimal OLR under thermophilic condition was 2.5 g of volatile solids (VS)/L/day with methane yield (MY) of 541 mL/g of VSadded. In addition, the optimal OLR under mesophilic condition was 1.5 g of VS/L/day with a MY of 371 mL/g of VSadded. At the same OLR, the MY under thermophilic condition was 33–49% higher than that under mesophilic condition. Under thermophilic condition, steady methane production and degradation efficiency were achieved with considerably high OLR of 7.5 g of VS/L/day. Under mesophilic condition, stability was obtained only when the OLR was controlled below 2.5 g of VS/L/day. Results also revealed that food waste is a highly desirable substrate w.
ROTAVIRUS: A REVIEW AND EMERGENCE OF NEW GENOTYPES

Rotavirus infection, which is directly related to the population’s quality of life, can culminate in death, mainly of children. This review discusses the prevalence and distribution of rotavirus genotypes, focusing on the genotypic variation of the virus after the implementation of vaccines and the cross-infection between animal and human species. It was searched the published literature from January 2006 to July 2017 using the Web of Knowledge database and the search terms “rotavirus”, “genotype”, “prevalence post vaccine”, and “emerging genotypes”. It was observed that the predominant genotypes changed in all continents, and that some genotypes are still emerging. Two hypotheses for this global change are the genetic variability of the virus and the emergence of vaccine-resistant genotypes. In addition, the virus can easily infect several animal species other than humans, as evidenced by reports of cross-infection of strains, which have served as warning for the generation of new virus genotypes. Inter-sectoral actions that encompass not only the health sector, but also all the socio-economic sector including the government, researchers, teachers, health agents, and communities contribute to decrease health-related expenditures and reduce mortality caused by the rotavirus, thereby improving health indicators and promoting health around the world.
THE EFFECT OF PROFIT GROWTH, FIRM SIZE, AND LIQUIDITY OF EARNINGS QUALITY

This study aimed to examine the effect of profit growth, firm size, and liquidity to the earnings quality. This study uses secondary data from the financial statements of pharmaceuticals published by Indonesia Stock Exchange during 2013 to 2017. Sampling technique by using purposive sampling. The sample in this study is pharmaceuticals company listed in Indonesia Stock Exchange as many as 7 companies. Method of data were analyzed by multiple linear regression. The result of partially test shows that profit growth and firm size had effect to earnings quality, and the liquidity had not effect to earnings quality. However, the result of simultaneously test show that profit growth, firm size, and liquidity had effect to earnings quality.
Investigando Técnicas de Recomendação de Assets Híbridos de Software: Um Mapeamento Sistemático

Software reuse is an effective alternative in creating software with quality, for it allows the creation of new software from existing ones. Thanks to the vast availability of resources available to developers and to software houses, software reuse becomes more promising, yet more challenging. In order to make opportunistic reuse a more effective approach, machine learning techniques have been added to opportunistic reuse processes. This study summarizes a systematic mapping, characterizing how the machine learning area has supported the reuse of hybrid software assets. Our results indicate that there is no single approach that stands out from the others, opening space for comparative studies in the area. Resumo. O reuso de software é uma alternativa efetiva para criar software com qualidade, por permitir criar novos produtos a partir de software já existente. Graças à vasta disponibilidade de recursos disponı́veis para desenvolvedores e empresas, o reuso de software se torna mais promissor, e ao mesmo tempo, mais desafiador. De modo a tornar o reuso oportunista uma abordagem mais efetiva,técnicas da área de aprendizado de máquina vem sendo acrescentadas aos processos de reúso. Este estudo sumariza um mapeamento sistemático sobre como a área de aprendizado de máquina tem dado suporte ao reúso de assets hı́bridos de software. Nossos resultados apontam que não há uma única abordagem que se destaque das demais, abrindo espaço para estudos comparativos.
ANALYSIS Analysis of Influence on PT. Astra Agro Lestari Tbk Financial Performance in Measuring Financial Statements in 2018-2019 Period

This research aims to see how the financial performance of PT. Astra Agro Lestari Tbk in the period 2018-2019 by measuring financial statements using ratio analysis. Ratio analysis is an appropriate method for measuring financial performance using Liquidity, Solvency, Activity, and Profitability ratios. Data and information in this study were obtained from the Indonesia Stock Exchange. The result of this calculation is that the liquidity ratio has increased, which is good for the company. The solvency ratio shows that the company is not sufficient to guarantee the debt provided by creditors so that the company can be said to be in bad condition. The ratio of the company’s activity has increased and also decreased. Whereas the profitability ratio results always decrease so the company has suffered losses, the company must increase its financial performance again.
A Horizontal Approach to Communication for Human-Robot Joint Action: Towards Situated and Sustainable Robotics

This paper aims at presenting a horizontal approach to the design of communication for joint action in human-robot interaction. According to this approach, social robotics must focus on different parameters of the whole joint action including context, the embedded situation and human psychological profile during the design and test process. Such an approach aims at complementing the standard building-block model that represents the state-of-the-art in robotic communication. Moreover, we provide some general ideas of how the model can facilitate the use of available communicative strategies for creating more efficient culturally sustainable robots in contexts of joint action.
Sorption of Pb(II) by bituminous coal

Removal of Pb(II) on bituminous coal at different pH values has been investigated. Maximum sorption (92.52%) observed at pH 8 and this pH value has been related with pK value. Langmuir model has been used to calculate sorption capacity of bituminous coal.
Superior Performance of Fully Biobased Poly(lactide) via Stereocomplexation-Induced Phase Separation: Structure versus Property

Superior properties such as high strength, toughness and transparency of fully biobased poly(lactide) (PLA) were achieved simultaneously without any external modifiers. The improvement in properties is well explained by a structural/morphological study. Stereocomplex PLA (SC-PLA) was obtained by melt compounding asymmetric poly(l-lactide)/poly(d-lactide) (PLLA/PDLA) blends at 200 °C and confirmed by wide-angle X-ray diffraction (WAXD) and differential scanning calorimetry (DSC) analyses. The SC-PLA domains (d = 950–1200 nm) lead to a physical cross-link network in the PLLA matrix. Rheology and Molau experiment reveal two different microstructures as a function of SC-PLA content, i.e., the connection of SC-PLA domains varied from chain entanglement to direct molecular bridging when the SC-PLA content increased from 10% to 23%. The SC-PLA crystals and the cross-link network reinforced the PLLA matrix, resulting in increases in melt viscosity, modulus and yield strength. Surprisingly, the elongation at break.
Applying Knowledge Discovery Process in General Aviation Flight Performance Analysis

The air transportation is a technology-intensive industry that has found itself collecting large volumes of data in a variety of forms from daily operations. Aviation data play a critical role in numerous aspects of aviation industry, aircraft flight performance is one of the most important uses of aviation data. Aircraft operational data are usually collected using aircraft onboard flight data recording devices and have been traditionally used for monitoring flight safety and aircraft maintenance with basic statistical analysis and threshold exceedance detection. With the development of data science and advanced computing technology, there is a growing awareness of incorporating knowledge discovery process into aviation operations. This article provides a review of recent studies on flight data analysis with two example studies on applying knowledge discovery process in flight performance analyses of general aviation.