Miracle-dz/UniFAR-FTUs huggingface dataset:
Modulation of Selective Attention by Sequential Effects in Visual Search Tasks

In visual search detection of a target on one display facilitates its subsequent recognition on the next (Rabbitt, Cumming and Vyas, 1977). Experiment I shows that facilitation also occurs when a different display intervenes between two displays containing targets. Two further experiments show that detection of target letters among background letters is also facilitated if the same background letters recur on successive displays. Facilitation is greatest if background letters reappear in identical left-to-right spatial locations, but is also evident when the same background letters recur in different locations on successive displays. The results suggest modifications to models for the ways in which selective attention is continuously modulated by successive events during serial search.
Expression of HIF-1alpha in injured arteries controls SDF-1alpha mediated neointima formation in apolipoprotein E deficient mice.

OBJECTIVE Hypoxia-inducible factor (HIF)-1alpha is the regulatory subunit of a transcriptional complex, which controls the recruitment of multipotent progenitor cells and tissue repair in ischemic tissue by inducing stromal cell-derived factor (SDF)-1alpha expression. Because HIF-1alpha can be activated under normoxic conditions in smooth muscle cells (SMCs) by platelet products, we investigated the role of HIF-1alpha in SDF-1alpha-mediated neointima formation after vascular injury. METHODS AND RESULTS Wire-induced injury of the left carotid artery was performed in apolipoprotein E-deficient mice. HIF-1alpha expression was increased in the media as early as 1 day after injury, predominantly in SMCs. Nuclear translocation of HIF-1alpha and colocalization with SDF-1alpha was detected in neointimal cells after 2 weeks. HIF-1alpha mRNA expression was induced at 6 hours after injury as determined by real-time RT-PCR. Inhibition of HIF-1alpha expression by local application of HIF-1alpha-siRNA reduced the neointimal area by 49% and significantly decreased the neointimal SMCs content compared with control-siRNA. HIF-1alpha and SDF-1alpha expression were clearly diminished in neointimal cells of HIF-1alpha-siRNA treated arteries. CONCLUSIONS HIF-1alpha expression is directly involved in neointimal formation after vascular injury and mediates the upregulation of SDF-1alpha, which may affect the stem cell-based repair of injured arteries.
Evolution of Developmental Control Mechanisms The segmentation cascade in the centipede Strigamia maritima: Involvement of the Notch pathway and pair-rule gene homologues

The centipede Strigamia maritima forms all of its segments during embryogenesis. Trunk segments formsequentially from an apparently undifferentiated disk of cells at the posterior of the germ band. We havepreviously described periodic patterns of gene expression in this posterior disc that precede overtdifferentiation of segments, and suggested that a segmentation oscillator may be operating in the posteriordisc. We nowshowthat genesof the Notch signalling pathway, including the ligand Delta, and homologues ofthe Drosophila pair-rule genes even-skipped and hairy, show periodic expression in the posterior disc,consistent with their involvement in, or regulation by, such an oscillator. These genes are expressed in apatternofapparentlyexpandingconcentricringsaroundtheproctodeum,whichbecomestripesatthebaseofthe germ band where segments are emerging. In this transition zone, these primary stripes deﬁne a doublesegment periodicity: segmental stripes of engrailed expression, which mark the posterior of each segment,arise at two different phases of the primary pattern. Delta and even-skipped are also activated in secondarystripes that intercalate between primary stripes in this region, further deﬁning the single segment repeat.These data, together with observations that Notch mediated signalling is required for segment patternformation in otherarthropods, suggest that the ancestral arthropod segmentation cascade may have involveda segmentation oscillator that utilised Notch signalling. © 2008 Elsevier Inc. All rights reserved.
General RNA binding proteins render translation cap dependent.

Translation in rabbit reticulocyte lysate is relatively independent of the presence of the mRNA m7G cap structure and the cap binding protein, eIF‐4E. In addition, initiation occurs frequently at spurious internal sites. Here we show that a critical parameter which contributes to cap‐dependent translation is the amount of general RNA binding proteins in the extract. Addition of several general RNA binding proteins, such as hnRNP A1, La autoantigen, pyrimidine tract binding protein (hnRNP I/PTB) and the major core protein of cytoplasmic mRNP (p50), rendered translation in a rabbit reticulocyte lysate cap dependent. These proteins drastically inhibited the translation of an uncapped mRNA, but had no effect on translation of a capped mRNA. Based on these and other results, we suggest that one function of general mRNA binding proteins in the cytoplasm is to promote ribosome binding by a 5′ end, cap‐mediated mechanism, and prevent spurious initiations at aberrant translation start sites.
Amyloid degeneration of the human brain following X-ray therapy.

Case 1. History: C. R. (No. 10718), a white female, aged 42 years, entered the hospital in December, 1940, for the treatment of a basal cell carcinoma of the left temple. She was exposed to 6000 I' (as measured in air) in ten treatments within twelve days, with 600 r applied daily at 150 K.v. without filter (half value layer at 0.25 millimeters of copper). The size of the field was 57 x 41 millimeters. The treatment was concluded on January 15,1941; two months later the tumor had disappeared. Twenty-two months later, the tumor is said to have reoccurred in the same location; however, the nature of the lesion was not verified histologically, and it is not certain that it was carcinomatous. The left temporal area was subjected to a second series of X-ray treatments in another hospital, consisting of 3600 I' at 180 K.v. in twenty-four sessions of 150 I' per treatment. The exact size of the field and type of filter used were not reported. The second course of X-ray treatments was concluded on December 5, 1942. Following the second irradiation, the patient remained well for four years, and then, approximately seventy-one months after the first course of X-ray treatments, she became nervous, complained of general malaise, headaches; she experienced some speech difficulty and impaired vision. Examination: The skin of the left temple was atrophic, scaling, and red in color. There was no visible tumor in the skin. She manifested a mild expressive aphasia and showed bilateral papilledema with an elevation of four to five diopters on the right and of four diopters on the left. Pneumoventriculograms showed marked displacement to the right of the right lateral and third ventricles. Angiograms demonstrated displacement of the left anterior cerebral artery to the right across' the midline and downward. The artery was curved around a space-occupying lesion in the left posterior frontal area. An electroencephalogram indicated a space-occupying lesion, but not neoplastic in nature (Dr. B. K. Bagchi). Course: A left fronto-temporal osteoplastic craniotomy was performed on July 3, 1946 (Bassett). Skull and dura showed no significant changes. In the left superior and inferior frontal gyri, including the area of Broca, in the mid-portion of the left orbital gyri, and in the mid-portion of the superior temporal gyrus, the brain tissue was purplish-gray in color and well demarcated. The gross appearance of the lesion suggested a glioma. The affected tissue was removed with the exception of an area about 2 cm. square, which apparently ex-
Ion pair formation involving methylated lysine side chains: A theoretical study

Lysine residues with one, two, or three methyl groups substituted on the ϵ‐nitrogen atom are found in many proteins. To evaluate the effect of the posttranslational methylation on ion‐pair formation we have performed semiempirical and ab initio molecular orbital calculations, using the AMI method and the 6‐31G* basis set, respectively. Combinations of various methylated forms of methylamine and ethylamine with formate, acetate, and dimethyl phosphate were studied as model compounds. This approach allowed us to obtain information relevant to the interaction of the modified Lys residues with carboxylate groups of proteins, and the backbone of nucleic acids. We have found that the interaction energy decreases with an increasing number of methyl groups. Inclusion of a solvent reaction field in the semiempirical calculations gave reasonable values for the interaction energy in aqueous solution, when formate and acetate were the counterions. These studies suggest that, in addition to other factors, a weakening of ionic interactions contributes to the various physiological effects of lysine methylation. © 1994 John Wiley & Sons, Inc.
The implications of genetics in colorectal cancer.

carcinogenesis. Genes (high and low penetrance genes and modiﬁer genes) and environment inﬂuence the development of sporadic, familial and genetic colorectal cancers. The size of the pies is based on present knowledge, which may change as more data on molecular genetic background of sporadic colorectal cancer are acquired.
Prevalence of Mycoplasma agalactiae Antibodies in Czech and Jordanian Herds of Small Ruminants

Madanat A. , D. Zendulkova, P. Lany, Z. Pospi‰il, P. âihal: Prevalence of Mycoplasma agalactiae Antibodies in Czech and Jordanian Herds of Small Ruminants. Acta Vet. Brno 2002, 71: 37-44. We investigated the presence of antibodies against Mycoplasma agalactiae, a causal agent of contagious agalactia, in herds of small ruminants. Eighty serum samples collected from 60 sheep and 20 goats in the Czech Republic and 137 samples collected from 78 sheep and 59 goats in Jordan were examined in our laboratory. Only the Jordan animals showed clinical signs of the disease. The sera were analysed for the presence of antibodies by a specific enzyme immunoassay. Of the 137 Jordan sera, eight gave positive reactions, 11 reactions were dubious and 117 were negative. All sera from the Czech animals showed negative reactions. The results provide evidence that, as expected, the Czech Republic is currently free from the mycoplasma agent causing contagious agalactia of sheep and goats and that, in Jordan as well as in many other Arabic countries, this disease is a frequent and serious health problem in herds of small ruminants. Sheep, goat, contagious agalactia, serum antibody, Mycoplasma agalactiae, enzyme immunoassay
Zellweger Syndrome and Associated Brain Malformations

Zellweger syndrome (cerebrohepatorenal syndrome) is very rare and is the most severe form of peroxisomal biogenesis disorders. These can be caused by mutations in any of the currently known Peroxin genes and typically present in the neonatal period with multiorgan involvement. Patients usually do not survive beyond 1 year of age. This article reports a case of Zellweger syndrome in a male Native American infant confirmed by clinical findings, imaging studies, and biochemical analysis. Genetic studies show a novel mutation (c.3030G>T, p. Glutamine1010Histidine) altering the last nucleotide of exon 19 in the Peroxin1 (PEX1) gene.
ANTIOXIDANT IN VIVO , IN VITRO ACTIVITY ASSESSMENT AND ACUTE TOXICITY OF AQUEOUS EXTRACT OF GOMPHRENA

Many plants possess antioxidant ingredients that provided efficacy by additive or synergistic activities. Gomphrena celosioides (Amaranthaceae) was used for treatment of icterus, and malaria in Africa. In this study, we evaluated the in vivo, in vitro antioxidant activity and acute toxicity effects of Gomphrena celosioides(Gc). Acute toxicity study was undertaken on 48 rats using 100 to 4000 mg kg 1 of Gc. In vivo antioxidant activity was determined, 20 Rabbits were divided into 4 groups of 5 animals. Group 1 to 2 received Gc 100-200 mg kg per by intraperitoneally during 3days. Group 3 received vitamin C (10 mg kg per day) as a reference antioxidant for comparison. Group4 was treated as control and received only saline (NaCl 0.9%). In each group, a blood sample was taken on the first day (J0) before the extract injection and then after extract injection at days 3(J3), 6 (J6), J9 (J9) and 12 (J12).
Analytically solvable two-level quantum systems and Landau-Zener interferometry

I present a simple algorithm based on a type of partial reverse-engineering that generates an unlimited number of exact analytical solutions to the Schrodinger equation for a general time-dependent two-level Hamiltonian. I demonstrate this method by deriving new exact solutions corresponding to fast control pulses that contain arbitrarily many tunable parameters. It is shown that the formalism is naturally suited to generating analytical control protocols that perform precise non-adiabatic rapid passage and Landau-Zener interferometry near the quantum speed limit. A general, exact formula for Landau-Zener interference patterns is derived.
Esculin-based medium for isolation and identification of Cryptococcus neoformans

A simple medium was developed, using esculin as the substrate, for the isolation and identification of Cryptococcus neoformans. C. neoformans produced a brown-black pigment on the medium; all other yeasts produced no pigment or were light yellow. Esculin is beta-glucose-6,7-dihydroxycoumarin. C. neoformans produced pigment because the 6,7-dihydroxycoumarin component of the esculin molecule was converted to a melanin-like pigment. We think the reaction was similar to the conversion of diphenols, aminophenols, and diaminobenzenes to melanin. Laboratory studies with isolates of C. neoformans, C. albidus, C. luteolus, and C. terreus and representatives of the genera Candida, Torulopsis, Geotrichum, and Rhodotorula, plus environmental field studies, demonstrated that over 95% of C. neoformans isolates were correctly identified, whereas all other fungi were excluded. Esculin agar was a sensitive, specific medium for the isolation and identification of C. neoformans. It was inexpensive and had a long storage life.
A protocol for visual cues in collaborative augmented reality applications

Inspection and maintenance of complex hardware equipment can have an elevated cost, due to the sophisticated training required for the technicians responsible for those tasks. The use of collaborative Augmented Reality can solve, or at least reduce, the cost of these activities. This paper proposes a protocol for the transmission of visual cues, represented by Augmented Reality elements, in collaborative applications. The protocol focuses on a client-server communication, where the client has the role to remotely supervise the activities, possibly sending interest points or instruction to the server. A prototype application was developed in order to demonstrate the advantages of a real application usage.
Suppression of the oestrous responses of bitches to the GnRH analogue deslorelin by progestin.

Studies were undertaken in Australia and Belgium to determine whether the initial pro-oestrous-oestrous responses of anoestrous bitches to treatment with deslorelin administered in a s.c. implant were inhibited by progestin treatment. Thirty-nine bitches of mixed breeding were treated daily with 2 mg megestrol acetate kg-1 body weight for 21 (group 1, n = 5) or 14 days (group 2, n = 10), or with 1 mg megestrol acetate kg-1 body weight for 14 days (group 3, n = 10). A deslorelin (6 mg) implant was placed s.c. on day 14 (group 1) or day 7 (groups 2 and 3) of treatment. Bitches not treated with progestin also received a deslorelin implant (group 4, n = 9) or were untreated controls (group 5, n = 9). Signs of pro-oestrus-oestrus were not observed in bitches in groups 1, 2 and 5, but were observed in bitches in groups 3 (4/10) and 4 (9/9). Four bitches in group 4 were mated, two of which became pregnant. The pregnancies failed at about day 40 of gestation and were associated with low plasma progesterone concentrations. Treatment with progestin inhibited the pro-oestrous-oestrous responses of bitches to deslorelin.
Nomenclature for factors of the HLA system, update March 2017

The following sequences have been submitted to the Nomenclature Committee since the February 2017 nomenclature update and, following agreed policy, have been assigned official allele designations. Complete details of all sequences will be published in a forthcoming report. Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new human leukocyte antigen (HLA) sequences is given in Table 3. The sequence DPA1*02:02:01 has been shown to contain errors and be identical to DPA1*02:07:01:01. The name DPA1*02:02:01 has been abandoned. All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the World Wide Web at: www.ebi. ac.uk/ipd/imgt/hla.
First trimester ultrasonography in screening and detection of fetal anomalies

An obstetrical ultrasound examination provides invaluable information regarding the fetus. Until the mid‐1980s, ultrasound in the first trimester was limited to localization of the pregnancy, establishing viability, and accurate dating. With the advent of high‐resolution ultrasound and transvaginal scanning, a significant amount of information about the fetus can be gained and provided to the patient at a very early stage in gestation. This article provides an overview of the role of first trimester (11–13 + 6 weeks' gestation) ultrasound in screening and diagnosis of fetal anomalies. The first trimester is an ideal time for screening for aneuploidy, primarily due to the advantages that nuchal translucency (NT) measurement provides. NT measurement is also useful in establishing the risk of congenital cardiac disorders and a number of genetic and non‐genetic syndromes. Significant NT thickening is associated with an increase in perinatal morbidity and mortality. Potential mechanisms resulting in increased NT are discussed. A number of new ultrasound markers for fetal aneuploidy have been investigated over the past several years, some of which appear to improve the screening efficacy of early ultrasonography. The role of these is reviewed. A number of fetal anomalies can now be consistently diagnosed in the first trimester. Their appearance at this early gestational age is discussed as well. It is clear that, data obtained by first trimester ultrasound are useful in counseling expectant parents and in planning the appropriate follow‐up. © 2007 Wiley‐Liss, Inc.
Application of Modal Analysis for Extraction of Geometrical Features of Biological Objects Set

This article presents application of modal analysis for the computation of data base of biological objects set and extraction of three dimensional geometrical features. Authors apply two types of modal analysis: physical (vibration modes) and empirical (PCA – Principal Component Analysis) for human bones. In this work as the biological objects the fifteen human femur bones were used. The geometry of each bone was obtained by using of 3D structural light scanner. In this paper the results of vibration modal analysis (modes and frequencies) and PCA (mean shape and features – modes) were presented and discussed. Further the possibilities of application of empirical modes for creation three dimensional anthropometric data base were presented.
Surgeon infects patient with hepatitis C

Officials at the Department of Health have no plans to introduce routine hepatitis C tests for healthcare workers after the announcement last week that a surgeon had infected a woman patient with the bloodborne virus. The incident is thought to be the third documented case of a patient being infected with the virus by a surgeon. The surgeon, who had worked at the Pilgrim Hospital in Boston, Lincolnshire, since 1997, is on sick leave. A sample of his blood taken two years ago, before the woman's operation, was found to be positive for the virus. Since the case came to light, another blood sample, taken in 1993 by the hospital that then employed the surgeon, the Torbay District General Hospital, has also been …
Doping Control Via Molecularly Engineered Surface Ligand Coordination

A means to control the net doping of a CQD solid is identified via the design of the bidentate ligand crosslinking the material. The strategy does not rely on implementing different atmospheres at different steps in device processing, but instead is a robust strategy implemented in a single processing ambient. We achieve an order of magnitude difference in doping that allows us to build a graded photovoltaic device and maintain high current and voltage at maximum power-point conditions.
Thermal Stability of Escherichia coli Ribonuclease HI and Its Active Site Mutants in the Presence and Absence of the Mg2+ Ion

Escherichia coli ribonuclease HI, which requires divalent cations (Mg2+ or Mn2+) for activity, was thermostabilized by 2.6-3.0 kcal/mol in the presence of the Mg2+, Mn2+, or Ca2+ ion, probably because the negative charge repulsion around the active site was canceled upon the binding of these metal ions. The dissociation constants were determined to be 0.71 mM for Mg2+, 0.035 mM for Mn2+, and 0.16 mM for Ca2+. Likewise, various active site mutants at Asp10, Glu48, Asp70, or Asp134 were thermostabilized by 0.4-3.0 kcal/mol in the presence of the Mg2+ ion, suggesting that this ion binds to these mutant proteins as well. The dissociation constants of Mg2+ were determined to be 9.8 mM for D10N, 1.1 mM for E48Q, 18.8 mM for D70N, and 1.8 mM for D134N. Thus, the mutation of Asp10 or Asp70 to Asn considerably impairs the Mg2+ binding, whereas the mutation of Glu48 to Gln or Asp134 to Asn does not. Comparison of the thermal stability of the mutant proteins with that of the wild-type protein in the absence of the Mg2+ ion suggests that the negative charge repulsion between Asp10 and Asp70 is responsible for the binding of the metal cofactor. Glu48 may be required to anchor a water molecule, which functions as a general acid.
A QoS-Based Scheme for Planning and Dimensioning of Optical Label Switched Networks

To support the growing demand for transmission, optical label switching (OLS) technology seems to be attractive due to its ability to allow fast switching and quality of service (QoS) support. Planning is a major issue in optical networks, since switch design and data transmission costs are essential criteria in OLS networks. In this paper, we use a novel OLS node architecture to build planning and dimensioning of OLS network based on a set of QoS parameters. We address the issue of providing the differentiated services to IP traffic through the use of optical buffering and link capabilities. We also formulate dimensioning and optimization problems using a conservation law and queuing model. Finally, we evaluate the performance of the proposed model through simulation.