Miracle-dz/UniFAR-FTUs huggingface dataset:
The cost of a disease targeted for elimination in Brazil: the case of schistosomiasis mansoni

BACKGROUND Schistosomiasis mansoni is a poverty-related parasitic infection that has a variety of clinical manifestations. We consider the disability and deaths caused by schistosomiasis unacceptable for a tool-ready disease. Its condition in Brazil warrants an analysis that will enable better understanding of the local health losses and contribute to the complex decision-making process. OBJECTIVE This study estimates the cost of schistosomiasis in Brazil in 2015. METHODS We conducted a cost of illness study of schistosomiasis mansoni in Brazil in 2015 based on a prevalence approach and from a societal perspective. The study included 26,499 schistosomiasis carriers, 397 hepatosplenic cases, 48 cases with the neurological form, 284 hospitalisations, and 11,368.26 years of life lost (YLL) of which 5,187 years are attributable to economically active age groups. RESULTS The total cost of schistosomiasis mansoni in Brazil was estimated to be US$ 41,7million in 2015 with 94.61% of this being indirect costs. CONCLUSIONS The economic burden of schistosomiasis mansoni in Brazil is high and results in the loss of productivity. Its persistence in Brazil is a challenge to public health and requires inter-sectorial interventions in areas such as indoor water supply, basic sanitation, and education.
Extreme High Efficiency Non-Inverting Buck-Boost Converter for Energy Storage Systems

This paper presents a high efficiency bidirectional non-inverting buck-boost converter for energy storage systems. A new control concept for achieving high efficient power conversion within a wide power range is introduced. A 3 kW prototype is designed and tested with Siand SiC-MOSFETs. Experimental results show that the prototype achieves a minimum efficiency of more than 98% at 5% load and a maximum efficiency of more than 99.4% at the operating points where the output voltage approaches the level of the input voltage.
Study of Agave Fiber-Reinforced Biocomposite Films

Thermoplastic resins (linear low-density polyethylene (LLDPE), high-density polyethylene (HDPE), and polypropylene (PP)) reinforced by different content ratios of raw agave fibers were prepared and characterized in terms of their mechanical, thermal, and chemical properties as well as their morphology. The morphological properties of agave fibers and films were characterized by scanning electron microscopy and the variations in chemical interactions between the filler and matrix materials were studied using Fourier-transform infrared spectroscopy. No significant chemical interaction between the filler and matrix was observed. Melting point and crystallinity of the composites were evaluated for the effect of agave fiber on thermal properties of the composites, and modulus and yield strength parameters were inspected for mechanical analysis. While addition of natural fillers did not affect the overall thermal properties of the composite materials, elastic modulus and yielding stress exhibited direct correlation to the filler content and increased as the fiber content was increased. The highest elastic moduli were achieved with 20 wt % agave fiber for all the three composites. The values were increased by 319.3%, 69.2%, and 57.2%, for LLDPE, HDPE, and PP, respectively. The optimum yield stresses were achieved with 20 wt % fiber for LLDPE increasing by 84.2% and with 30 wt % for both HDPE and PP, increasing by 52% and 12.3% respectively.
Revisiting the Cholinergic Hypothesis in Alzheimer’s Disease: Emerging Evidence from Translational and Clinical Research

Scientific evidence collected over the past 4 decades suggests that a loss of cholinergic innervation in the cerebral cortex of patients with Alzheimer’s disease is an early pathogenic event correlated with cognitive impairment. This evidence led to the formulation of the “Cholinergic Hypothesis of AD” and the development of cholinesterase inhibitor therapies. Although approved only as symptomatic therapies, recent studies suggest that long-term use of these drugs may also have disease-modifying benefits. A Cholinergic System Workgroup reassessed the role of the cholinergic system on AD pathogenesis in light of recent data, including neuroimaging data charting the progression of neurodegeneration in the cholinergic system and suggesting that cholinergic therapy may slow brain atrophy. Other pathways that contribute to cholinergic synaptic loss and their effect on cognitive impairment in AD were also reviewed. These studies indicate that the cholinergic system as one of several interacting systems failures that contribute to AD pathogenesis.
Aging‐related changes of cognitive performance and stress regulation in high functioning elderly individuals

This article aims to analyse long‐term changes in cognitive performance and psychophysiological stress regulation in a specific sample of 10 young‐old (age at pre‐test: M ± SD = 63.2 ± 1.5) and 12 old‐old (age at pre‐test: M ± SD = 69 ± 2) persons possessing a high psychosocial status and a physically active lifestyle. Psychophysiological parameters were recorded prior to, during, and after the administration of a cognitive performance test battery. The measurements took place three times within a 6‐month period, and again 6 years later in a follow‐up test. Considering practice and habituation effects, findings provide no compelling evidence of an aging‐associated cognitive decline in attention, multiple choice reaction performance, and information processing speed, either in the young‐olds, or in the old‐olds. Furthermore, psychophysiological stress regulation showed no long‐term alteration regarding skin conductance level and heart rate. Based on these findings, it is assumed that psychosocial health and physical activity might contribute to the preservation of cognitive abilities and stress regulation into the 70s. Finally, this study demonstrated the significance of considering practice and habituation effects elicited through test repetitions in order to estimate long‐term effects.
Molecular biomarkers in cardiac hypertrophy

Cardiac hypertrophy is characterized by an increase in myocyte size in the absence of cell division. This condition is thought to be an adaptive response to cardiac wall stress resulting from the enhanced cardiac afterload. The pathogenesis of heart dysfunction, which is one of the primary causes of morbidity and mortality in elderly people, is often associated with myocardial remodelling caused by cardiac hypertrophy. In order to well understand the potential mechanisms, we described the molecules involved in the development and progression of myocardial hypertrophy. Increasing evidence has indicated that micro‐RNAs are involved in the pathogenesis of cardiac hypertrophy. In addition, molecular biomarkers including vascular endothelial growth factor B, NAD‐dependent deacetylase sirtuin‐3, growth/differentiation factor 15 and glycoprotein 130, also play important roles in the development of myocardial hypertrophy. Knowing the regulatory mechanisms of these biomarkers in the heart may help identify new molecular targets for the treatment of cardiac hypertrophy.
Cellular Responses of Industrially Relevant Silica Dust on Human Glial Cells In Vitro

Despite the rigorous emission control measures in the ferroalloy industry, there are still emissions of dust during the production of various alloys. Dust particles were collected from laboratory scale processes where oxide particulate matter was formed from liquid silicon (metallurgical grade). The dust was produced in a dry air atmosphere to mimic industrial conditions. To investigate possible effects of ultrafine dust on the central nervous system, a human astrocytic cell line was employed to investigate inflammatory effects of particles as astrocytes play a number of active and neuron supporting roles in the brain. Toxicity on the astrocytes by amorphous silica generated in laboratory scale was compared to crystalline macro-sized silica using several doses to determine toxicological dose response curves. The cell viability experiments indicated that low particle doses of amorphous silica induced a small nonsignificant reduction in cell viability compared to crystalline silica which led to increased levels of toxicity. The gene expression of amyloid precursor protein (APP), a biomarker of neurodegenerative disease, was affected by particle exposure. Furthermore, particle exposure, in a dose-and time-dependent manner, affected the ability of the cells to communicate through gap junction channels. In conclusion, in vitro studies using low doses of particles are important to understand mechanisms of toxicity of occupational exposure to silica particles. However, these studies cannot be extrapolated to real exposure scenarios at work place, therefore, controlling and keeping the particle exposure levels low at the work place, would prevent potential negative health effects.
Prevention of Alcohol Use in Older Teens: A Randomized Trial of an Online Family Prevention Program

This study examines effects of a randomized controlled trial for an online, family-based prevention program for older teens, Smart Choices 4 Teens, on alcohol use and related outcomes. Families (N = 411; teen age M = 16.4, SD = 0.5) were randomly assigned to the intervention or control condition in 2014–2015. Both intent to treat (ITT) and dosage models were conducted. ITT models: At the 6-month follow-up, teens in the experimental condition reported fewer friends who had been drunk, and parents in the experimental group reported more communication about social host laws. At the 12-month follow-up, parents in the experimental condition reported consuming fewer drinks than parents in the control group. Dosage models: At the 6-month follow-up, dosage was inversely related to teen drinking in the past 6 months or 30 days, frequency of teen drinking during the past 6 months and 30 days, drinks consumed by teens over the past 6 months, teen drunkenness and binge-drinking during the past 30 days, teen reported communication about safe drinking and positively related to parent and teen reported communication about social host laws. At 12 months, dosage was inversely related to teen alcohol use, frequency of teen drinking over the past 30 days, drinks consumed by teens over the past 6 months and 30 days, and teen drunkenness over the past 6 months. Results suggest that Smart Choices 4 Teens is beneficial for families. Dissemination and implementation strategies that motivate completion of program content will improve outcomes related to older teens’ alcohol use.
Inflammatory profile of chronic apical periodontitis: a literature review

Abstract Apical periodontitis caused by root canal infection is the most frequent pathological lesion in the jaws, mainly manifested as periapical granulomas and cysts. Understanding of the formation and progression of apical periodontitis as well as the identification of inflammatory biomarkers can help increase the knowledge of pathogenic mechanisms, improve the diagnosis and provide support for different therapeutic strategies. The objective of the present article is to review inflammatory biomarkers such as cytokines, chemokines, inflammatory cells, neuropeptides, RANK/RANKL/OPG system and other inflammatory markers and to relate these systems to the development and progression of pathological conditions related to apical periodontitis.
Functional Repair Assay for the Diagnosis of Constitutional Mismatch Repair Deficiency From Non-Neoplastic Tissue.

PURPOSE Constitutional mismatch repair deficiency (CMMRD) is a highly penetrant cancer predisposition syndrome caused by biallelic mutations in mismatch repair (MMR) genes. As several cancer syndromes are clinically similar, accurate diagnosis is critical to cancer screening and treatment. As genetic diagnosis is confounded by 15 or more pseudogenes and variants of uncertain significance, a robust diagnostic assay is urgently needed. We sought to determine whether an assay that directly measures MMR activity could accurately diagnose CMMRD. PATIENTS AND METHODS In vitro MMR activity was quantified using a 3'-nicked G-T mismatched DNA substrate, which requires MSH2-MSH6 and MLH1-PMS2 for repair. We quantified MMR activity from 20 Epstein-Barr virus-transformed lymphoblastoid cell lines from patients with confirmed CMMRD. We also tested 20 lymphoblastoid cell lines from patients who were suspected for CMMRD. We also characterized MMR activity from patients with neurofibromatosis type 1, Li-Fraumeni syndrome, polymerase proofreading-associated cancer syndrome, and Lynch syndrome. RESULTS All CMMRD cell lines had low MMR activity (n = 20; mean, 4.14 ± 1.56%) relative to controls (n = 6; mean, 44.00 ± 8.65%; P < .001). Repair was restored by complementation with the missing protein, which confirmed MMR deficiency. All cases of patients with suspected CMMRD were accurately diagnosed. Individuals with Lynch syndrome (n = 28), neurofibromatosis type 1 (n = 5), Li-Fraumeni syndrome (n = 5), and polymerase proofreading-associated cancer syndrome (n = 3) had MMR activity that was comparable to controls. To accelerate testing, we measured MMR activity directly from fresh lymphocytes, which yielded results in 8 days. CONCLUSION On the basis of the current data set, the in vitro G-T repair assay was able to diagnose CMMRD with 100% specificity and sensitivity. Rapid diagnosis before surgery in non-neoplastic tissues could speed proper therapeutic management.
Allergic contact dermatitis probably caused by latanoprost during treatment for alopecia areata

Latanoprost is a phenyl-substituted analogue of prostaglandin F2α used to treat glaucoma (1). Recently, it has been shown to stimulate eyelash hypertrichosis and therefore it has been proposed as a possible treatment for alopecia (2). Despite the extensive use of the drug in ophthalmology, allergic contact dermatitis (ACD) due to latanoprost has rarely been reported in glaucoma patients (3-6). We report a case of ACD very probably due to latanoprost used for the treatment of alopecia areata in a woman. This article is protected by copyright. All rights reserved.
0192 Implementing Themes From Serious Incidents Into Simulation Training For Junior Doctors

Background A tenth of patients admitted to hospitals may be subjected to avoidable harm.1 Junior doctors are very likely to be involved in such incidents.2,3 In the University Hospitals of Leicester, each reported serious incident (SI) undergoes a root cause analysis and an action plan is implemented for each SI. Tackling each SI independently is an approach that does not address recurrent errors across incidents. Simulation offers a platform to implement the educational principle of “learning from mistakes” in a safe environment. This study describes the implementation of a simulation programme based on recurring themes across SIs in a large NHS trust. Methodology SI reports involving junior doctors over a two year period were qualitatively analysed to identify recurring themes across incidents. These themes were used to design high-fidelity simulation scenarios which were integrated into a training programme for postgraduate medical trainees across numerous specialties. Time was allocated for debriefing using the principles of “advocacy with enquiry”. The simulation was complemented by a reflective exercise using a written narrative of a real serious incident. Trainees then filled an online evaluation questionnaire. Results Recurring themes included “poor prescribing practice”, “failure of clinical reasoning”, “poor record keeping”. 19 trainees underwent a one day fully immersive simulation course in groups of three to six, participating in three scenarios. 100% of trainees felt that the scenarios were realistic, 90% felt that this educational approach could reduce the number of SIs, 100% felt that the group discussion on a real SI allowed them to reflect on ways to reduce errors in clinical practice. Potential impact This model demonstrates how simulation can be used as a potent educational tool to promote active learning from important themes leading to SIs. The next step involves performing a departmental qualitative analysis followed by multi-disciplinary departmental simulation training. Correction notice MDW was removed from this author list as she was involved in the investigative stage and not involved in the interventional stage, which was what this abstract is mostly about. References National Audit Office. Patient Safety. 2009: HC 151-I Berk WA, Welch RD, Levy PD, et al. The effect of clinical experience on the error rate of emergency physicians. Ann Emerg Med 2008;52(5):497–501
Time-Frequency Analysis of Gamelan Sound Signals using Continuous Wavelet Transform

Most automatic music transcription research is related with Western music, and still less for the Javanese gamelan music. In this paper we present a process for determining the gamelan music transcription using Continuous Wavelet Transform (CWT). Several complex continuous w avelet are applied to obtain the coefficients or time-frequency representation. And then some features, such as onset and pitch, are extracted from these representation. There are many possible wavelets, but not all are appropriate for automatic gamelan notes transcription. In this research, we compare and select the appropriate Wavelet using two criterias, that are good frequency resolution and less processing time. The Cmor20-1 and Cmor50-1 Wavelet have faster processing time, but produce a wider frequency resolution. Instead Cmor 2 0-3 and Cmor 5 0- 3 give a better frequency resolution but require a longer processing time. Our evaluation shows that w avelet transform can be used to give 0.11 MAPE. STFT can only give us performance 0.72 for window size 16384. Based on these results, it can be mentioned that the w avelet ha s good frequency resolution than STFT.
A shift of treatment approach in speech language pathology services for children with speech sound disorders – a single case study of an intense intervention based on non-linear phonology and motor-learning principles

ABSTRACT Even though there are documented benefits of direct intensive intervention for children with speech sound disorders (SSDs), the intensity given at Swedish Speech Language Pathology services rarely exceeds once a week. Also, indirect therapy approaches are commonly employed. The purpose of the present case study was to investigate the effects of an intensive specialist therapy, based on non-linear phonological analysis and motor learning principles. The participant was a boy aged 4:10 years with severe SSD, who previously had received indirect therapy from age 3 with, very limited results. A single subject ABA design was used. At baseline, whole word match was 0%, Word shape CV match was 39% and PCC was 22, 7%. He had no multisyllabic words, no consonant clusters and no established coronals. Intervention was given 4 days weekly for 3 weeks in two periods with a 7-week intervening break and a post therapy assessments. Therapy was focused on establishing multisyllabic words, iambic stress pattern, clusters and coronals with the principle of using already established elements for targeting new elements. At post therapy assessment, whole word match was 39%, word shape CV match was 71% and PCC 69.1%. Multisyllabic words (86%), coronals (82%) and word initial clusters (80%) were established. Without being targeted, back vowels were also present and segment timing improved. The strong treatment effects of this study demonstrate that at least severe cases of SSD require the clinical knowledge and skills that only a SLP can provide and that frequent direct therapy is both beneficial and needed.
Kids Code in a rural village in Norway: could code clubs be a new arena for increasing girls’ digital interest and competence?

ABSTRACT A trend, where voluntary groups teach children and youth basic computer coding skills, has spread throughout the world. After-school clubs invite children to create games in visual programming environments. The activities emphasize play, while teaching principles of computer science. We explore this phenomenon based on observations and interviews at a code club in Norway, asking whether coding represents an important skill for children and how it is distributed to include all children. We find that coding through play activity is perceived as teaching more than simply the technical skills of programming. Although the fun aspect draws in children and volunteers, parents and instructors describe the code club as being about learning to understand and control the computer, and digital competence required for achieving success in society. The Code Club is described partly as being a ‘necessity for becoming a good/efficient/empowered citizen in our digital society’, and partly as ‘children are playing with computers anyway’. These arguments have different consequences for the gender imbalance at the Code Club. Our findings suggest that the code clubs need an explicit recruitment strategy targeting girls in order to become an arena where girls can develop interest and competence in digital technologies.
Macrophage Polarization is Deregulated in Haemophilia

Abstract Macrophages make important contributions to inflammation and wound healing. We show here that macrophage polarization is deregulated in haemophilia in response to macrophage colony-stimulating factor (M-CSF) and partially in response to granulocyte-macrophage colony-stimulating factor (GM-CSF). As a result, haemophilia macrophages exhibit a specific impairment of M-CSF-mediated functions involved in wound healing such as clot invasion and phagocytosis. Haemophilia monocytes express reduced amounts of the receptors for M-CSF and GM-CSF, which correlates with a failure to express tumour necrosis factor α (TNFα) and CD163 in M-CSF-treated haemophilia macrophages and reduced expression of TNFα and CD206 after treatment with GM-CSF. Protein expression in response to M-CSF was regained with respect to CD163 and CD206 after embedding haemophilia monocytes in clotted plasma suggesting that a functioning coagulation system has positive effects on macrophage M2 polarization. Mimicking the functional deficits of haemophilia macrophages in normal macrophages was possible by adding leptin, which we found to be elevated in the blood of haemophilia patients, to a monocyte cell line. The increase of leptin occurred in conjunction with C-reactive protein in a body mass index-controlled cohort suggesting that haemophilia patients harbour chronic low-grade inflammation. Together, our data indicate that impaired clotting in haemophilia patients leads to increased inflammation and a deregulation in macrophage differentiation, which may explain the commonly observed deficits in wound healing and tissue regeneration.