Miracle-dz/UniFAR-FTUs huggingface dataset:
SPARC is Required for Larval Development and Regulation of Fat Body Dynamics in Drosophila melanogaster

SPARC is a highly conserved trimodular Caand Collagen-binding matricellular protein with diverse functions during development, wound healing and cancer metastasis. Our lab previously generated an embryonic lethal Drosophila SPARC null mutant, Df(3R)nm136, analysis of which revealed that SPARC was required for the deposition of Collagen IV into basal laminae and normal nervous system development during embryogenesis. In contrast to these previous studies, my data revealed that SPARC is not required for the deposition of Collagen IV into embryonic basal laminae or embryonic nervous system development. Further analysis showed that the Df(3R)nm136 chromosome carried a second-site mutation in the Neuralized locus which caused the nervous system defects and embryonic lethality previously associated with a loss of SPARC. Removal of this second site mutation and reanalysis of the SPARC mutant phenotype revealed that SPARC is required for larval development where it appears to play a role in the regulation fat body remodelling. SPARC mutant fat bodies showed changes in cell shape and basal lamina remodelling which
Cranial Variation in Man: A Study by Multivariate Analysis of Patterns of Difference Among Recent Human Populations

ETUDE STATISTIQUE PAR LA METHODE DE L'ANALYSE MULTIVARIEE ET DE L'ANALYSE FACTORIELLE DES RELATIONS DE VARIATION DANS LA FORME DU CRANE HUMAIN, APPLIQUEE A DES ECHANTILLONS D'EUROPE, D'AFRIQUE, D'ASIE, D'OCEANIE, D'AMERIQUE DU NORD ET D'AMERIQUE DU SUD. LES CARACTERISTIQUES DES RACES RESSORTENT TRES FORTEMENT, ET LES RESULTATS COINCIDENT POUR LES SERIES MASCULINES ET FEMININES.
Ideal Time of Vaginal Misoprostol Administration in nulliparous women undergoing Office Hysteroscopy: a randomized double blind placebo controlled study

Background: hysteroscopy is the process of viewing and operating in the endometrial cavity from a transcervical approach. It is the gold standard procedure for uterine cavity exploration. Objective: to detect ideal time of vaginal misoprostol administration for cervical priming in nulliparous women prior to office hysteroscopy by comparing between giving 400 microgram 3 hours, 6 hours and 12 hours before office hysteroscopy. Patients and Methods: randomized double-blind placebo-controlled study. This study was done on 198 patients to whom office hysteroscopy was done as a part of investigation of (infertility,recurrent miscarriage or abnormal uterine bleeding). Result: in group A which received 400μgm vaginal misoprostol 12 hours before office hysteroscopy, pain score was lower compared to group B compared to group C . Procedural time was shorter in group A compared to group B compared to group C , cervical entry was easier in group A compared to group B compared to group C , baseline cervical dilatation was greater in group A compared to group B compared to group C vaginal bleeding was least in group A compared to group B compared to group C . Conclusion: use of 400μgm vaginal misoprostol 12 hours before hysteroscopy is better than using it 6 hours and 3 hours in facilitating cervical ripening with minimal side effects without use of anasthesia.as it decrease pain score, decrease procedure duration, increase ease of cervical entry, higher patient acceptability and with minimal side effects
La protéine non-structurale NS1 du virus West Nile : étude fonctionnelle et cible potentielle de nouvelles molécules antivirales

Parmi les virus emergents transmis par des moustiques (arbovirus), le genre flavivirus est fortement represente avec les virus Dengue, Zika, et le virus West Nile (WNV). Le WNV est responsable de nombreux cas de maladies neuroinvasives severes, parfois mortelles, chez l'humain et les chevaux. Ce virus represente donc un probleme de sante publique humaine et animale. Il n'existe pour le moment aucun vaccin humain ni aucun traitement specifique anti-WNV.Parmi les determinants viraux essentiels a l'infection par les flavivirus, la glycoproteine non-structurale NS1 possede des proprietes multifonctionnelles. La forme sNS1, secretee dans le milieu extracellulaire, est fortement impliquee dans la deregulation du systeme immunitaire de l'hote. Ces mecanismes participent a l'evasion du virus a la reponse antivirale et, paradoxalement, a la pathogenese observee dans les formes severes de la maladie. L'essentiel de ces donnees concernant le virus de la Dengue, nous souhaitions etudier les proprietes fonctionnelles, in vitro, de la proteine sNS1WNV au cours de l'infection de cellules epitheliales, gliales et neuronales de mammiferes. En effet, la structure des proteines sNS1 de flavivirus etant tres similaire, notre hypothese suppose un role de sNS1WNV dans les infections neuroinvasives.Si la proteine sNS1WNV ne semble pas moduler les etapes de l'infection virale, elle est cependant a l'origine d'un remodelage du cytosquelette d'actine dans les cellules epitheliales. Elle est aussi impliquee dans l'activation de voies antivirales chez les cellules neuronales non infectees. D'autre part, en ciblant sNS1 et la proteine d'enveloppe E du WNV, nous avons pu isoler, par criblage de molecules aRep (proteines artificielles a motifs repetes), des ligands de haute affinite pour ces determinants viraux. Ces nouvelles molecules, capables de se lier specifiquement aux proteines sNS1 et E, ont le potentiel pour servir de base au developpement de nouveaux outils de diagnostics et d'agents therapeutiques antiviraux
ESCHERICHIA COLI O157:H7 IN FOOD WITH HEALTH-RELATED RISKS

E. coli O157:H7 has been implicated in many cases of food contamination across the world, in both the beef and poultry industries, with approximately 1,000 E. coli O157 cases reported in Journal of research in health science www.journalofresearch.org No 1 (1), September-October 2017 info@journalofresearch.org Health Sciences ____________________ Israel, Yashresh 6 UK each year. This includes 100 cases of haemolytic uraemic syndrome, a serious illness that can cause acute renal failure. Indeed, E. coli O157:H7 infections are of particular concern due to the potential severity of symptoms. An estimated 73,500 cases of illness, 2000 hospitalisations and 60 deaths occur each year in the USA due to E. coli O157 infection, costing approximately $1 billion a year in medical costs and lost productivity E. coli O157:H7 is regarded as being more transmissible than other E. coli serotypes for a number of reasons, including its increased tolerance to acid, which allows it to easily survive the acidic conditions of the stomach. This bacterium also produces Shiga toxins, which are heat stable, and therefore unaffected by conventional pasteurization methods. Small doses of fewer than 10 cells may lead to infection. Collectively, these factors make the control of E. coli O157:H7 an important issue in recent times for the food sector. Many preventative measures have been introduced and targeted at all stages of the food chain, from the farm, to the slaughterhouse, and to the preparation of food at home.
Removal of Basic Violet from Wool Dyeing Effluent Using Nanoparticles

ABSTRACT In the reported study, nano silica and nano clay were used to remove the residual color from effluent generated during the dyeing of wool fabric with basic violet. Various concentrations (0.1%, 0.25%, 0.5%, and 1.0%) of the nanoparticles were treated with dye effluent for different durations and the results are compared with the color removal of commercial activated carbon. The nanoparticles were characterized for their physical properties including particle size, FTIR, and TEM. Freundlich isotherm was used for the dye adsorption studies. The FTIR and TEM analysis depicted the characteristic peaks and crystal geometry for the selected nanoparticles. The treated effluent showed a significant reduction in color, biological, and chemical oxygen demand (more than 99%). The treatment was optimized for 1.0% adsorbent concentration for 60 minutes. The color removal efficiency of nano silica was found to be higher at low concentration; however, the efficiency of nano clay exceeded at a higher concentration of adsorbents.
Monocular Visual Odometry Based on Depth and Optical Flow Using Deep Learning

Visual odometry (VO) is one of the essential techniques in mobile robots field; an accurate VO system is of great significance for mobile robot simultaneous localization and mapping. As for traditional monocular VO systems, they work by presuming the monocular scale is 1 (scale = 1), or relying on ground truth (GT) to estimate scale. As a result, the traditional monocular VO systems estimate the pose state with big drift or cannot work on the image sequence without GT. Although some classical monocular VO systems have been proposed, they still have imperfect performance or even unable to work in some extreme scene conditions, such as scene is monotony without obvious texture information or camera large-scale displacement motion. As for learning-based VO system, it is realized by training deep neural networks in supervised or self-supervised manner to end-to-end estimate the pose state; however, the accuracy of pose estimation entirely depends on the ability of networks. Although the ability of networks can be improved by increasing the number of training data sets and optimizing the network structure, it is inevitable to encounter problems such as insufficient generalization ability and insufficient accuracy on rotational pose estimation. In this article, a monocular VO system named DL_Hybrid is proposed, which takes full advantage of DL networks used in image processing and geometric localization theory based on hybrid pose estimation methods. The DL_Hybrid VO system can estimate a six-DoF pose one-frame-by-one-frame and recover camera trajectory, and it can extract accurate key points from per-frame even in extreme scene condition, and it has good performance even in the extreme moving condition, such as camera rotation-only action or static action, also it can work well in the condition of camera large-scale displacement motion. The real scale is also accurately estimated without depending on GT, and the pose estimation method is designed based on hybrid 2d–2d and 3d–2d localization theory to make the DL_Hyrid VO system to estimate translational and rotational information with accuracy and robustness. Experimental results show that the proposed DL_Hybrid VO system has a better performance than traditional and learning-based VO systems.
Assessment of Undergraduate University Students’ Knowledge and Awareness of Oral Cancers in Brunei Darussalam

Aims: The objective of this study is to assess current level of awareness and knowledge of oral cancer among undergraduate students in Brunei Darussalam Study Design: Cross-sectional study using self-administered questionnaire Methodology: The English language self-administered questionnaires were distributed to a random sample of undergraduates in the two universities. The respective university representatives distributed the questionnaires to students from random modules. 184 students from UBD and 198 students from UTB were included. The questionnaire has been pretested by 5 university students before the study began. Results: A total of 392 students completed the questionnaires. Only 46.4% of the students were aware of the term ‘oral cancer’ and mere 1.5% were able to identify oral cancer diagnostic tests. Overall oral cancer knowledge level was low with a mean knowledge score of 37.3% only. However, 76.3% (95%CI: 71.9, 80.3) were able to identify tobacco smoking as a risk factor followed by poor oral hygiene 55.5% (95%CI: 61.6, 71.2) and 53.3% (95%CI: 48.2, 58.3) chewing tobacco or betel nut. Conclusion: Oral cancer awareness and knowledge among undergraduates is poor. Effective oral cancer promotion and education by relevant agencies are highly suggested, particularly in tertiary education settings.
Étude de la modulation de la voie canonique d'activation de NF-kB par les protéines non structurales du virus Nipah

Le virus Nipah (NiV) est un paramyxovirus zoonotique du genre Henipavirus, qui a emerge en 1998. NiV infecte l'homme et cause des troubles respiratoires et des encephalites avec une forte letalite. A l’inverse, chez les hotes naturels de NiV, les chauves-souris de la famille des Pteropodidae, l’infection est asymptomatique. Cependant, les mecanismes permettant aux Pteropodidae de controler l’infection sont inconnus a ce jour. NiV produit des proteines non structurales, V, W et C, qui sont des facteurs de virulence. V, W et C inhibent les voies de l’interferon de type 1. De plus, la proteine W inhibe la production de chimiokines in vitro et module la reponse inflammatoire in vivo, mais son mecanisme d’action reste inconnu. La voie NF-κB etant le principal regulateur de la reponse inflammatoire, nous avons emis l’hypothese que W pourrait moduler la voie NF-κB. Nous avons demontre que la proteine W inhibe l'activation de la voie canonique de NF-κB induite par TNFα et IL-1β, effet pour lequel sa region C-terminale specifique est necessaire. Nous avons egalement identifie quels signaux d’import et d’export nucleaires de W sont necessaires a son effet inhibiteur et ainsi mis en evidence l’importance du trafic nucleo-cytoplasmique de W pour l’inhibition de NF-κB. L’etude des interactions de W avec les proteines cellulaires nous a permis d’identifier un partenaire prometteur connu pour son role dans le retrocontrole negatif de NF-κB. Enfin, le role de W dans l'inhibition de la voie NF-κB a ete demontre pendant l'infection par NiV. Les resultats obtenus ouvrent la voie a la comprehension du mecanisme par lequel W module la reponse inflammatoire. Finalement, afin de mieux comprendre le controle de l’infection de NiV par son hote naturel, nous avons genere des lignees cellulaires primaires et immortalisees de chauve-souris Pteropus giganteus. Ces cellules devraient permettre de mieux comprendre les mecanismes par lesquels ces chauves-souris controlent l’infection virale.
Change in sex pheromone expression by nutritional shift in male cockroaches

Environmental conditions during sexual maturation impact sexual signal expression, but little is known about how individual histories of changing environmental conditions affect the intensity of male sexual advertisement. We investigated the effects of shifting dietary nutrient composition (protein vs. carbohydrates) in male Nauphoeta cinerea cockroaches on consumption, final lipid reserves, and sex pheromone levels subsequent to completing sexual maturation on a specific diet, at high and low concentration of dietary nutrients. Consumption, lipid reserves, and sex pheromone levels were highly affected by dietary nutrient composition with higher values on car-bohydrate-biased diet, and males had significantly higher and lower levels of consumption, lipid reserves, and sex pheromones when shifted to a carbohydrate-biased and a protein-biased diet, respectively, compared with males maintained on either initial diet throughout the experiment. Males shifted to a carbohydrate-biased diet at high nutrient concentration fully recouped their sex pheromone levels, attaining levels that were not significantly lower than those in males maintained on carbohydrate-biased diet at high nutrient concentration throughout the experiment. Our study shows that male sexual display in N. cinerea is plastic and highly affected by pres-ent as well as previous dietary conditions. Signaling of adaptive quality through male sex pheromones can therefore vary dynamically within the early adult life of a male in response to the nutritional composition of food that is available to ingest. This contrasts morphological sexual traits in arthropods that are affected during development and are fixed at adulthood.
Reduction of Benzo(a)pyrene Content in Sesame Oil by Using Adsorbents

This study was conducted to reduce benzo(a)pyrene in sesame oil by addition of several kinds of absorbents (active carbon, diatomaceous earth, kaolin, acid clay, perlite, and silicate). Sesame oil containing 4.1 ppb benzo(a)pyrene was stirred with 0.2% (w/w) several kinds of adsorbents at 40°C for 30 min. Active carbon resulted in the highest reduction of benzo(a)pyrene in sesame oil among the investigated adsorbents, and decolorization was observed only by using silicate. Reduction of benzo(a)pyrene was optimized by controlling amount the of active carbon, stirring time, and stirring temperature. Futher, 4.1 ppb benzo(a)pyrene in sesame oil was reduced by up to 0.91 ppb by adding 0.5% (w/w) active carbon and stirring for 30 min at 70°C. Optimized conditions were applied to sesame oil (2.14～4.11 ppb) purchased from a Gyeonggi traditional market, and benzo(a)pyrene in sesame oil was reduced by up 0.43～0.86 ppb.
On the Identity of Sphaenorhynchus platycephalus (Werner, 1894) (Anura: Hylidae)

Abstract. Sphaenorhynchus platycephalus was briefly described on the basis of a single specimen, with only “S-Amerika” as its locality. Although it has been regarded as a distinct species, compelling evidence is lacking. A comparison of all currently described species of Sphaenorhynchus, including type specimens of several species, allowed us to provide morphological evidence that S. platycephalus and S. orophilus are conspecific, with S. orophilus being a junior synonym of S. platycephalus.
Factors Affecting Sustainable Tourism Development in Ba Ria-Vung Tau, Vietnam

Sustainable development – including tourism development – is the general trend of all economies. With the orientation to build and develop the tourism industry into a key economic sector and become a tourist center of the Southeast region, Vietnam, Ba Ria-Vung Tau Province is demanding a proper, rational, development policy, while ensuring the development and exploitation of immediate natural advantages, and ensuring long-term sustainable development. The objective of this study is to examine the factors and their trends in sustainable tourism development in Ba Ria-Vung Tau Province, Vietnam. Methods used include descriptive statistical analysis, exploratory factor analysis and regression analysis. Data was collected from the results of a survey of 550 domestic and foreign tourists visiting Ba Ria-Vung Tau. With the help of SPSS statistical software, 12 groups of factors affecting sustainable development were identified including: economy, society, environment, humanistic tourism resources, natural tourism resources, tourism human resources, tourism products and service, tourism quality, infrastructure, technical facilities, governmental management and group of criteria to evaluate sustainable tourism development. The research results show that there are four groups of factors that significantly affect sustainable tourism development in Ba Ria-Vung Tau. These are groups of factors: Society, Environment, Tourism products and service, and Technical facilities.
First genome-wide analysis of an endangered lichen reveals isolation by distance and strong population structure

Lichenized fungi are evolutionarily diverse and ecologically important, but little is known about the processes driving diversification and genetic differentiation in these lineages. Though few studies have examined population genetic patterns in lichens, their geographic distributions are often assumed to be wholly shaped by ecological requirements rather than dispersal limitations. Furthermore, while their reproductive structures are observable, the lack of information about recombination mechanisms and rates can make inferences about reproductive strategies difficult. Here we investigate the population genomics of Cetradonia linearis, an endangered lichen narrowly endemic to the southern Appalachians of eastern North America, to test the relative contributions of environmental factors and geographic distance in shaping genetic structure, and to gain insights into the demography and reproductive biology of range restricted fungi. Analysis of genome-wide SNP data indicated strong evidence for both low rates of recombination and for strong isolation by distance, but did not support isolation by environment. Hindcast species distribution models and the spatial distribution of genetic diversity also suggested that C. linearis had a larger range during the last glacial maximum, especially in the southern portion of its current extent, consistent with previous findings in other southern Appalachian taxa. These results contribute to our understanding of intrinsic and extrinsic factors shaping genetic diversity and biogeographic patterns in C. linearis, and more broadly, in rare and endangered fungi.
Financial slack, institutional shareholding and enterprise innovation investment: evidence from China

This study examines how institutional shareholding affects the relationship between financial slack and corporate investment in innovation for Chinese A-share listed companies We find that financial slack significantly increases corporate innovation investment Pressure-resistant institutions do not moderate the relation but pressure-sensitive institutions do moderate the relation negatively We further find that financial slack affects beneficially results because of the employment of slack resources after an exogenous negative shock like COVID-19/Global Financial Crisis Our findings contribute to the literature on the cross-sectional variation on the relationship between companies’ strategies and accounting choices in China © 2020 Accounting and Finance Association of Australia and New Zealand
The interaction of homoserine lactones and paraoxonase 2 modulates cell death signaling and cell proliferation.

S SUBMITTED TO REGIONAL AND NATIONAL MEETINGS: Aaron M. Neely, Guoping Zhao, Yanglong Zhu Colins O. Eno, Yanlong, Lynn DeLeeuw, Joseph A. Burlison, Jonathan B. Chaires, John O. Trent, and Chi Li. Inducing tumor cell apoptosis by a small molecule activating Bax. The American Society of Cell Biology Annual Meeting December 2016 Neely, A.M., Zhao, G. , Whitt A. , Chi L. , Scwarzer C. , Huayi, L. , Stivers, N. , Burlison, J., Machen, T. and Chi Li. The bacterial quorum sensing molecule N-(3oxo-acyl) homoserine lactone inhibits tumor growth independent of Bcl-2 proteins. The Ohio Valley Society of Toxicology Meeting October 2016 Neely, A.M., Zhao, G. , Whitt A. , Chi L. , Scwarzer C. , Huayi, L. , Stivers, N. , Burlison, J., Machen, T. and Chi Li. The bacterial quorum sensing molecule N-(3oxo-acyl) homoserine lactone inhibits tumor growth independent of Bcl-2 proteins. Kentucky Lung Cancer Symposium October 2016 Neely, A.M., Zhao, G. , Whitt A. , Chi L. , Scwarzer C. , Huayi, L. , Stivers, N. , Burlison, J., Machen, T. and Chi Li. The bacterial quorum sensing molecule N-(3oxo-acyl) homoserine lactone inhibits tumor growth independent of Bcl-2 proteins. Research! Louisville October 2016 Neely, A.M., Zhao, G. , Whitt A. , Chi L. , Scwarzer C. , Huayi, L. , Stivers, N. , Burlison, J., Machen, T. and Chi Li. The bacterial quorum sensing molecule N-(3oxo-acyl) homoserine lactone inhibits tumor growth independent of Bcl-2