Miracle-dz/UniFAR-FTUs huggingface dataset:
Ultrasonic velocity detector in the diagnosis of thrombophlebitis.

The ultrasonic velocity detector is a noninvasive technique which can be used at the bedside to evaluate the deep venous system of patients with suspected thrombophlebitis. The technique has been used in 112 patients who presented with symptoms and signs suggestive of thrombophlebitis. The results of the ultrasonic testing program have been verified by 67 venograms in 53 patients and by operation in an additional 4 patients. The results of the velocity detector evaluation correlated well with those of venography in 93% of the patients studied. The technique is most accurate and useful in the case of occlusions in the iliofemoral and femoropopliteal venous segments. False negative examinations are most apt to occur with venous occlusions confined to small veins of the calf, which cannot be evaluated with the method.
Adaptive Capacity to Technological Change: A Microfoundational Approach

Research summary>: We take a microfoundational approach to understanding the origin of heterogeneity in firms' capacity to adapt to technological change. We develop a computational model of individual‐level learning in an organizational setting characterized by interdependence and ambiguity. The model leads to organizational outcomes with the canonical properties of routines: constancy, efficacy, and organizational memory. At the same time, the process generating these outcomes also produces heterogeneity in firms' adaptive capacity to different types of technological change. An implication is that exploration policy in the formative period of routine development can influence a firm's capacity to adapt to change in maturity. This points to a host of strategic trade‐offs, not only between performance and adaptive capacity, but also between adaptive capacities to different forms of change. Managerial summary: Why are firms differentially effective at adapting to technological change? We argue that firms differ in the adaptive capacity of the routines that underlie their capabilities. These differences arise well before change occurs, and result because firms build routines that are differentially responsive to signals of performance decline associated with technological change. Thus, early managerial efforts to build superior productive efficiency must be complemented by efforts to build superior adaptive capacity. Our theory suggests that managers can prepare for technological change by implementing policies, in the formative period of organizational development, that promote individuals' exploration of novel actions. However, there are trade‐offs because preparation aimed at building adaptive capacity to one type of technological change may limit adaptive capacity to other types of change. Copyright © 2016 John Wiley & Sons, Ltd.
The Impact of Corporate Social Responsibility on Profit and Deposit: A Study on Commercial Banks of Bangladesh

This paper is an effort to study the causal relationship between Corporate Social responsibility (CSR) expenditure of commercial banks Bangladesh and their profits and deposits. We applied OLS estimation on the panel data of seven commercial banks of Bangladesh from 2011 to 2015. We find a neutral relationship between CSR expenditure and profit, and a positive relationship between CSR and total deposit.
Nuclear Factors Bind to a Conserved DNA Element That Modulates Transcription of Anopheles gambiae Trypsin Genes*

The Anopheles gambiae trypsin family consists of seven genes that are transcribed in the gut of female mosquitoes in a temporal coordinated and mutually exclusive manner, suggesting the involvement of a complex transcription regulatory mechanism. We identified a highly conserved 12-nucleotide motif present in all A. gambiae and Anopheles stephensi trypsin promoters. We investigated the role of this putative trypsin regulatory element (PTRE) in controlling the transcription of the trypsin genes. Gel shift experiments demonstrated that nuclear proteins of A. gambiae cell lines formed two distinct complexes with probes encompassing the PTRE sequence. Mapping of the binding sites revealed that one of the complex has the specificity of a GATA transcription factor. Promoter constructs containing mutations in the PTRE sequence that selectively abolished the binding of either one or both complexes exerted opposite effects on the transcriptional activity of trypsin promoters in A. gambiae and Aedes aegypti cell lines. In addition, the expression of a novel GATA gene was highly enriched in A. gambiae guts. Taken together our data prove that factors binding to the PTRE region are key regulatory elements possibly involved in the blood meal-induced repression and activation of transcription inearly and late trypsin genes.
Acute abstinence syndrome following abrupt cessation of long‐term use of tramadol (Ultram®): a case study

We report on a patient who had taken the centrally acting analgesic tramadol for over 1 year. The compound had proven to be sufficient to treat her painful episodes related to fibromyalgia. Due to lack of supply while being on a trip, intake of the drug was stopped abruptly, resulting in the development of classical abstinence‐like symptoms within 1 week. Abstinence‐like symptoms consisted of restlessness and insomnia for which the benzodiazepine lorazepam was given. Diarrhoea and abdominal cramps were treated with the peripherally active opioid loperamide, while bouts of cephalgia were treated with sumatriptan. Diffuse musculoskeltal‐related pain and restless leg syndrome (RLS) were treated with dextromethorphan. All these different medications proved to be efficacious as they resulted in the cessation of symptoms. Within 1 week symptoms ceased and the patient regained her normal activities without any sequelae. Although tramadol is considered a non‐habit‐ and non‐dependence‐forming analgesic, abstinence symptoms are likely to develop following abrupt cessation of intake, especially when the compound had been taken over 1 year. Therefore patients should be advised of such an effect whenever they decide to stop intake or their physician is planning to switch to another medication. To avoid abstinence‐like symptoms doses should be slowly tapered down.
Red blood cell Na+/H+ and Li+/Na+ exchange in patients with essential hypertension.

The increased red blood cell Li+/Na+ exchange found in a subgroup of patients with essential hypertension (EH) may reflect an increased activity of the Na+/H+ exchange. The maximal velocity of the red cells' Na+/H+ (Na+ influx promoted by an outward H+ gradient) and Li+/Na+ (Li+ efflux promoted by external Na+) exchange were therefore measured in 41 EH and in 21 normotensive controls (NT). Both transporters were significantly higher in EH than in NT (74 +/- 39 mmol/L cell x h v 43 +/- 27 for the former, P less than .03, and 0.35 +/- 0.16 v 0.26 +/- 0.10 for the latter, P less than .05). Even though more than 100 times faster, Na+/H+ exchange was weakly but significantly correlated to Li+/Na+ exchange (r = 0.29, P less than .05). Proximal tubule Na+ reabsorption (fractional renal Li+ reabsorption) was significantly greater in EH than in NT (0.78 +/- 0.07, n = 32, v 0.73 +/- 0.06, n = 10, P less than .05) but it was not correlated to either the red cells' Na+/H+ or Li+/Na+ exchanges. Therefore, hyperactivity of Na+/H+ exchange in EH may play a role in blood pressure elevation through mechanisms other than stimulation of renal Na+ reabsorption.
Selective enrichment broth medium for isolation of Campylobacter jejuni

A new selective Campylobacter enrichment broth for the isolation of Campylobacter jejuni has been tested with fecal specimens of human, poultry, and bovine origin. We compared the isolation rate with that from the simultaneous direct plating of a duplicate specimen. Of the 380 duplicate specimens examined comparatively, we obtained a 46.3% increase in isolation of C. jejuni by using the new Campylobacter enrichment broth medium.
Electronic Stability Control Based on Motor Driving and Braking Torque Distribution for a Four In-Wheel Motor Drive Electric Vehicle

An electronic stability control (ESC) algorithm is proposed for a four in-wheel motor independent-drive electric vehicle (4MIDEV) utilizing motor driving and regenerative braking torque distribution control to improve vehicle stability. A stability judgment controller, an upper level controller, and a torque distribution algorithm are designed for the ESC system. The stability judgment controller is designed to generate the desired yaw rate and sideslip angle for vehicle stability, and the control mode, which is normal driving mode or ESC mode, is set according to the driver inputs and measurement signal inputs. The upper level controller consists of a speed tracking controller, a yaw moment controller, and four wheel-slip controllers to calculate the desired value of traction force, the desired value of yaw moment, and the four respective net torque inputs of the four in-wheel motors. The torque distribution algorithm is designed to generate each motor driving torque or regenerative braking torque input for each wheel. An average torque distribution strategy, a tire-dynamic-load-based torque distribution strategy, and a minimum-objective-function-based optimal torque distribution strategy are used separately in the torque distribution algorithm to control the motor driving torque or regenerative braking torque for vehicle stability enhancement. The proposed ESC algorithm was implemented and evaluated in a CarSim vehicle model and a MATLAB/Simulink control model. The three proposed torque distribution strategies can be used to regulate the vehicle to perform the following tasks: “single lane change,” “double lane change,” and “snake lane change. ” The simulation studies show that the yaw rate error root mean square [RMS $(\gamma-\gamma_\mathrm{-des})$] decreased, on average, by 75 percent using the proposed optimal torque distribution algorithm compared with that without using stability control.
Maternal prepregnancy body mass index and delivery of a preterm infant in missouri 1998-2000.

OBJECTIVE To determine risk of delivering a preterm infant (<37 weeks) in overweight/obese women. DESIGN Descriptive. SAMPLE Population-based sample of 169,881 singleton Missouri birth certificate records for 1998-2000. MEASURES Prepregnancy body mass index (BMI): underweight BMI<19.8; normal BMI=19.8-24.9; overweight BMI=25-29.9; and obese BMI> or =30; and preterm birth (<37 completed weeks' gestation). RESULTS In each BMI category, the percent of women who delivered a preterm infant is: underweight 11.5%, normal 8.3%, overweight 8.2%, and obese 8.5%. For women with a BMI of overweight (odds ratio [OR] 0.9, 95% confidence interval [CI]=0.8-0.9) and obese (OR 0.8, 95% CI=0.8-0.9), the risk of delivering a preterm infant decreased when compared with women with a BMI<19.8. Black (OR=2.5, 95% CI 2.4-2.6) and Hispanic (OR=1.4, 95% CI 1.2-1.5) women had a higher risk of preterm birth than White women when obesity, diabetes, hypertension, and prenatal care were controlled. Women with diabetes (OR=1.4, 95% CI=1.2-1.5), hypertension (OR=3.2, 95% CI=3.1-3.4), and those who smoked (OR=1.6, 95% CI=1.6-1.7) were at increased risk for a preterm birth. CONCLUSIONS Findings suggest that preconception and prenatal care focus on identification and management of risks associated with premature births and maternal risk factors such as diabetes, hypertension, and smoking.
Kip: het meest complexe stukje vlees : marktmechanismen, ketenrelaties en integrale duurzaamheid »

De structuur en de cultuur van de pluimveevleesketen en de afzonderlijke schakels zijn in deze rapportage onder de loep genomen. Tevens worden conclusies en aanbevelingen voor de pluimveevleesketen gepresenteerd, waarbij oplossingsrichtingen worden voorgesteld voor de problematiek waarmee de sector wordt geconfronteerd.
Action of metformin on the insulin-signaling pathway and on glucose transport in human granulosa cells.

CONTEXT Hyperinsulinemia in polycystic ovary syndrome is widely treated with the insulin sensitizer metformin, which, in addition to its systemic effects, directly affects the ovarian insulin-stimulated steroidogenesis pathway. OBJECTIVE Our aim was to investigate the interaction of metformin with the other insulin-stimulated ovarian pathway, namely that leading to glucose uptake. DESIGN Human granulosa-luteal cells were cultured with metformin (10(-7) M), insulin (10 ng/ml) or metformin and insulin (met + ins) combined. Insulin receptor (IR) involvement was assessed by culture with an (anti)-insulin receptor (IR) antibody. MAIN OUTCOME MEASURES The effect of metformin on insulin-receptor substrate proteins 1 and 2 (IRS-1 and -2) mRNA and protein expression was determined. The KGN granulosa-cell line was used to investigate the effect of insulin and metformin on Akt activation and glucose transporter-4 (Glut-4) expression. Glut-4 translocation from the cytosol to the membrane was determined in cytoplasmic and membrane-enriched fractions of protein lysates. RESULTS IRS-1 mRNA and protein increased with all treatments. In contrast, basal IRS-2 mRNA levels were barely detectable, but transcription was up-regulated by metformin. The anti-IR antibody reduced treatment-stimulated IRS-1 to basal levels and IRS-2 expression to an even greater extent than IRS-1, showing greater dependence on the IR than IRS-1. Metformin in the presence of insulin activated Akt and this was dependent on phosphoinositide-3 kinase, as was translocation of Glut-4 to the membrane. Metformin was able to substantially enhance the insulin-stimulated translocation of Glut-4 transporters from the cytosol to the membrane. CONCLUSION This net increase in Glut-4 transporters in the plasma membrane has the potential to increase glucose uptake and metabolism by granulosa cells of the insulin-resistant polycystic ovary, thereby facilitating follicle growth.
Developmental Changes in Progenitor Cell Responsiveness to Bone Morphogenetic Proteins Differentially Modulate Progressive CNS Lineage Fate

Although multipotent progenitor cells capable of generating neurons, astrocytes and oligodendrocytes are present within the germinal zones of the brain throughout embryonic, postnatal and adult life, the different neural cell types are generated within discrete temporospatial developmental windows. This might suggest that multipotent progenitor cells encounter different signals during each developmental stage, thus accounting for separate waves of lineage commitment and cellular differentiation. This study demonstrates, however, that progenitor cell responses to the same class of signals, the bone morphogenetic proteins (BMPs), change during ontogeny, and that these same signals may thus initiate progenitor cell elaboration of several different lineages. BMPs promote cell death and inhibit the proliferation of early (embryonic day 13, E13) ventricular zone progenitor cells. At later embryonic (E16) stages of cerebral cortical development, BMPs exhibit a concentration-dependent dissociation of cellular actions, with either enhancement of neuronal and astroglial elaboration (at 1–10 ng/ml) or potentiation of cell death (at 100 ng/ml). Finally, during the period of perinatal cortical gliogenesis, BMPs enhance astroglial lineage elaboration. By contrast, oligodendroglial lineage elaboration is inhibited by the BMPs at all stages. Further, application of the BMP antagonist noggin to cultured progenitors promotes the generation of oligodendrocytes, indicating that endogenous BMP signaling can actively suppress oligodendrogliogenesis. These observations suggest that developmental changes in neural progenitor cell responsiveness to the BMPs may represent a novel mechanism for orchestrating context-specific cellular events such as lineage elaboration and cellular viability.
Distribution and Diversity of Fiji's Terrestrial Herpetofauna: Implications for Forest Conservation1

ABSTRACT In 2003 The Wildlife Conservation Society attempted to evaluate the conservation status of Fiji's natural forests including identifying a series of biological provinces (based on the distribution and endemism of a number of terrestrial taxa) in which some form of conservation area would need to be established or maintained. A combination of literature surveys, consultations with local researchers, and targeted field surveys was used to identify herpetological provinces within Fiji. With the exception of the iguanas (restricted to dry forest habitats), the frogs, and one of the skink species (restricted to wet forest habitats), the herpetofauna of Fiji is widespread in terms of both geography and habitat type and consequently there are no real distinct species assemblages or communities. Based on areas with the highest levels of herpetofauna species richness and endemism, forest reserves need to be established or maintained on Yadua Taba, Taveuni (particularly the northern and eastern sides), Ono-i-Lau, Ovalau, Gau, Rotuma, and the Monasavu area of Viti Levu to maximize conservation of herpetofauna diversity. Because there are gaps in the knowledge of geographic distributions of species resulting from incomplete surveys of several areas of the country, further targeted surveys are needed to completely evaluate the distribution of all herpetofauna species in Fiji.
Effect of variability in anatomical landmark location on knee kinematic description

Small variability associated with identifying and locating anatomical landmarks on the knee has the potential to affect the joint coordinate systems and reported kinematic descriptions. The objectives of this study were to develop an approach to quantify the effect of landmark location variability on both tibiofemoral and patellofemoral kinematics and to identify the critical landmarks and associated degrees of freedom that most affected the kinematic measures. The commonly used three‐cylindric open‐chain kinematic description utilized measured rigid body kinematics from a cadaveric specimen during simulated gait. A probabilistic analysis was performed with 11 anatomical landmarks to predict the variability in each kinematic. The model predicted the absolute kinematic bounds and offset kinematic bounds, emphasizing profile shape, for each kinematic over the gait cycle, as well as the range of motion. Standard deviations of up to 2 mm were assumed for the anatomical landmark locations and resulted in significant variability in clinically relevant absolute kinematic parameters of up to 6.5° and 4.4 mm for tibiofemoral and 7.6° and 6.5 mm for patellofemoral kinematics. The location of the femoral epicondylar prominences had the greatest effect on both the tibiofemoral and patellofemoral kinematic descriptions. A quantitative understanding of the potential changes in kinematic description caused by anatomical landmark variability is important not only to the accuracy of kinematic gait studies and the evaluation of total knee arthroplasty implant performance, but also may impact component placement decision‐making in computer‐assisted surgery. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:1221–1230, 2007
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells

Maintenance of pluripotency is crucial to the mammalian embryo's ability to generate the extra-embryonic and embryonic tissues that are needed for intrauterine survival and foetal development. The recent establishment of embryonic stem cells from human blastocysts (hESCs) provides an opportunity to identify the factors supporting pluripotency at early stages of human development. Using this in vitro model, we have recently shown that Nodal can block neuronal differentiation, suggesting that TGFβ family members are involved in cell fate decisions of hESCs, including preservation of their pluripotency. Here, we report that Activin/Nodal signalling through Smad2/3 activation is necessary to maintain the pluripotent status of hESCs. Inhibition of Activin/Nodal signalling by follistatin and by overexpression of Lefty or Cerberus-Short, or by the Activin receptor inhibitor SB431542, precipitates hESC differentiation. Nevertheless, neither Nodal nor Activin is sufficient to sustain long-term hESC growth in a chemically defined medium without serum. Recent studies have shown that FGF2 can also maintain long-term expression of pluripotency markers, and we find that inhibition of the FGF signalling pathway by the tyrosine kinase inhibitor SU5402 causes hESC differentiation. However, this effect of FGF on hESC pluripotency depends on Activin/Nodal signalling, because it is blocked by SB431542. Finally, long-term maintenance of in-vitro pluripotency can be achieved with a combination of Activin or Nodal plus FGF2 in the absence of feeder-cell layers, conditioned medium or Serum Replacer. These findings suggest that the Activin/Nodal pathway maintains pluripotency through mechanism(s) in which FGF acts as a competence factor and therefore provide further evidence of distinct mechanisms for preservation of pluripotency in mouse and human ESCs.
Dynamic properties of partially denervated muscle

The mechanical and electrical properties of the partially denervated first dorsal interosseous muscle were measured in 14 patients and 14 normal control subjects. The following variables were studied during isometric contraction: maximum voluntary contraction; maximum rate of rise of tension in a rapid voluntary contraction; amplitude, rate of rise, time to peak, and duration of peak of the compound muscle action potential; twitch force, maximum rate of rise, contraction time, and half‐relaxation time; and tetanic (50 Hz) force, rate of rise, and tetanus/twitch ratio. The force produced during repetitive stimulation of the ulnar nerve at 10, 20, 50, and 100 impulses per second was also analyzed.
Welfare effects of one-sided regulation when internationally traded complements are unregulated

We consider the effects of a one-sided price regulation of one of two complementary inputs. The provider of the regulated component is a domestic firm, while the provider of the other component is a foreign firm. This describes the market structure for several digital information and communication services. We show that one-sided regulation may have negative welfare effects compared to a free market economy unless the regulator has a first-mover advantage. In the latter case, regulation is welfare enhancing regardless of whether the foreign input provider uses linear or non-linear wholesale prices. 1We would like to thank the EU Framework Programme 6 through the project CoCombine for financial support.
Motion planning using transient pixel representations

A method for finding optimal paths is investigated for a time-varying domain. The environment contains a set of time-varying obstacles whose motions are known. In a time-varying environment, paths are time-dependent, i.e., a path needs to be specified as a function of time, since connectivity in the environment changes over time. Given a time-varying environment, a start time, and a start location, a method is presented for finding a collision-free path from start to goal points for a robot subject to a speed bound. This method generates a path with minimum-length and a path with minimum-delay for each time interval in which the goal location is reachable. The problem is formulated by using a transient pixel representation to model an arbitrary time-varying environment and a concept of fast-to-short path lists. <<ETX>>