Miracle-dz/UniFAR-FTUs huggingface dataset:
Seven-year (yr) follow-up of adjuvant paclitaxel (T) and trastuzumab (H) (APT trial) for node-negative, HER2-positive breast cancer (BC).

511Background: Retrospective data suggest that patients (pts) with small HER2+ cancers have more than just minimal risk of disease recurrence. The APT trial was designed to address treatment for such pts. We have previously reported 3-yr disease-free survival (DFS) and here we provide an updated analysis with 7-yr DFS. Methods: APT is a single arm multicenter, phase II study of TH. Pts with HER2+ BC (IHC 3+ and/or FISH ratio > 2.0) with negative nodes (a single axillary lymph node micrometastasis was allowed) and tumor size < 3 cm were eligible. Pts received T (80 mg/m2) with H x 12 weekly (w), followed by H (weekly or q3w) x 39w. The primary endpoint was DFS. Recurrence Free Interval (RFI), Breast Cancer Specific Survival (BCSS), and overall survival (OS) were also analyzed. Intrinsic subtyping by PAM50 was performed on the nCounter Analysis system on archival tissue. Results: 410 pts were enrolled from September 2007 to September 2010 and 406 began protocol therapy. 67% had hormone-receptor (HR)+ tumors.
Évaluation des facteurs prédictifs de l'efficacité du pamidronate dans le syndrome douloureux régional complexe de type 1

Le syndrome douloureux chronique de type I est une affection complexe dont aucune strategie therapeutique n'est actuellement definie rendant sa prise en charge complexe. Objectif Evaluer les facteurs associes a la bonne reponse (amelioration de plus de 50% de l'EVA douleur) au traitement par perfusions de pamidronate, chez les patients atteints d'un SDRC I. Methode Cinquante-cinq patients atteints d'un SDRC I selon les criteres de Budapest ont ete inclus. Ces patients ont beneficie de trois perfusions de pamidronate espacees d'un mois. Le critere de jugement principal etait l'amelioration de plus de 50% de l'EVA douleur a 8 mois apres avoir debute le traitement par pamidronate. Les criteres de jugement secondaire etaient l'evaluation de l'activite du SDRC I, l'amelioration de la raideur articulaire ainsi que des scores de douleur neuropathique, de retentissement fonctionnel et de qualite de vie a huit mois. Resultats A huit mois, nous constations que 27,3% soit 15 patients presentaient une diminution de l'EVA douleur de plus de 50%. A huit mois, nous constations une amelioration significative des scores DN4, NPSI et du CSS. Les patients avec amelioration de l'EVA douleur a huit mois avaient une duree d'evolution de leur SDRC I significativement plus courte et des resultats de scintigraphie plus souvent positifs comparativement aux patients dont l'EVA douleur diminuaient de moins de 50%. Conclusion Il semble indique de proposer un traitement par pamidronate preferentiellement chez les patients atteints de SDRC I dont l'evolution est recente et ayant des signes scintigraphiques d'atteinte de SDRC I.
The Bright Side of Cost Transparency: Facilitating Product Innovation

A firm’s cost for its products is increasingly transparent to consumers as the firm itself or third parties publish such information. Using a dynamic model of firm pricing with forward-looking consumer choice, this paper assesses the effect of cost transparency on firm pricing, consumer surplus, firm profits and new product innovation. Cost transparency stymies the low-cost firm’s ability to intertemporally pricediscriminate because consumers now correctly anticipate the future price drops and delay purchases, as it is no longer feasible to pool price with the high-cost firms, whose future prices drop less because of the high cost. Thus, cost transparency will benefit the high-cost firms but hurt the low-cost firms. Surprisingly, consumers can also be hurt by cost transparency if the firm has a high cost. However, cost transparency leads to an expected increase in both firm profits and consumer surplus—a win-win for both firms and consumers. This increase in expected firm profits facilitates greater investment by firms in new-product innovation.
Effects of Ultrasonic Vibration on the Transport Coefficients in Plasma Arc Welding

In ultrasound assisted plasma arc welding (U-PAW), the exerted ultrasonic vibration on the tungsten electrode interacts with the plasma arc and changes its heat-pressure characteristics. It is of great significance to investigate the underlying interaction mechanism. In this study, the calculation method of transport coefficients in U-PAW is developed. Translational thermal conductivity (including electrons thermal conductivity and the thermal conductivity of heavy particles) and electrical conductivity are calculated by considering the second-order approximation of Maxwell velocity distribution function, while the method of Butler et al. is adopted to calculate the reaction thermal conductivity in U-PAW. The effective value of the ultrasound velocity gradient tensor is employed to describe the effects of ultrasonic vibration on transport coefficients in ultrasound assisted plasma arc. The calculation results show that when the ultrasound is applied, the thermal conductivity of heavy particles in the plasma increases significantly and the electron thermal conductivity increases within some extent. The thermal conductivity of the reaction also increased to a great extent, and the electrical conductivity decreases a little bit. Although the thermal diffusion coefficient also has some increase, but the ordinary diffusion coefficient is obviously reduced due to the application of the ultrasound. With the updated transport coefficients, the plasma arc pressure on the anode surface is numerically computed, and the predicted pressures of PAW and U-PAW can be consistent with the measured ones.
The Coaching LEADERSHIP through the Life and Humanity of Leader Yi Sun-Shin

This research aims to specify the coaching leadership through Korean traditional military leader Yi Sun-shin. The whole society of the 20th Century is very complicated not to make a decision. So in the era of this trend, the society needs to be guided by who got the Charismatic Leadership based on solid wisdom and self-moderation competence. Usually mysticism, elitism, and strong charisma have been known as typical leadership. But now world is changing rapidly, so 21st century is questioning new leadership to today’s leaders. If so, what is correct answer which leaders of this age must answer? It could be not charisma but ‘empathy’ and ‘de-authority’. Even the present generation leaves doubts to leadership itself from the very first. This research tried to draw a consensus between Yi Sun-sin Leadership through stage of lifetime based on 10 pictures and Coaching Leadership at shifting point of leadership paradigm. As results of analyzing 10 spectrums, wellspring of Yi Sun-sin Leadership becomes summarized 7 kinds of core key words as noble character, values, principle, genuine ability, horizontal communication, transformation and innovation, and justice. Those also can be discovered to attain the highest perfection of leadership by consilience of conventional and modern leadership theory. As this is existential leadership that this age is needed, it’s against the coaching leadership to help centering true-self as way of being. This study finds out common dominator between Leader Yi Sun-sin and Coaching Leadership by projecting Yi Sun-sin’s life to coaching philosophy and Coaching Core Competency(CCC). Even during 21 century, we have to still understand and pursue the greatest leader Yi Sun-sin’s authentic leadership. [Keywords] Leadership, Coaching Leadership, Yi Sun-Sin, 4Industrial Revolution, Authentic Leader-
Early persistent retinal fluid during treatment of neovascular AMD with ranibizumab and aflibercept

Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in subjects aged >65 years living in economically developed countries (1,2). As birthrates drop and life expectancy rises, the prevalence of AMD is expected to increase, along with the social and economical burden associated with the disease and its treatment. Anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the management of neovascular AMD (nAMD) and are now considered the mainstay of therapy (1,3). Although monthly injections seem to produce the best functional results according to clinical trials (4-7), the increasing patient numbers and exponentially growing costs made it clear that alternatives should be sought for a clinical practice setting. To this day, plentiful controversies still exist over the best available drug and treatment regimen for the management of nAMD. Variations in patient response to anti-VEGF therapy have been identified in clinical trials, regardless of the drug or regimen used. Understanding the reasons (epidemiological, genetic, functional, anatomical, etc.) behind these variations could help predict the injection requirements of individual patients, thus reducing unnecessary visits and preventing over- or undertreatment (8). Although most patients respond rapidly to anti-VEGF treatment, residual fluid on OCT persists in a subgroup of eyes across clinical trials of different drugs and regimens. Since treatment decisions are often driven by the presence of fluid on OCT, the quest for imaging biomarkers capable of predicting the functional and anatomical prognosis became the goal of several investigators.
Simultaneous measurements of strong-field ionization and high harmonic generation in aligned molecules

High harmonic spectroscopy relies on high harmonic generation (HHG) in aligned molecules. The first step of HHG is the ionization of the molecule in the intense femtosecond laser field. Here we present measurements of both ionization yield and high harmonic yield as a function of molecular angle in N2 and CO2 molecules. Measurements were done at two wavelengths, 800 and 1200 nm, and for a range of laser intensities, to study the sensitivity of laser conditions on both processes. The behavior of N2 was relatively insensitive to laser conditions. However in CO2, a minimum in high harmonic emission was observed that was sensitive to both laser intensity and wavelength, and was attributed to interference in emission from the HOMO and HOMO-2 orbitals.
An examination of non-addictive drug (mis)use and work absenteeism

ABSTRACT This article mainly examines the effect(s) of legal drug misuse on work absenteeism, which has a connecting influence to work productivity. Also, the analysis compares the effects of legal drug use (e.g., tranquilizers) on work absences to that of a commonly used, but illegal drug, marijuana. Utilizing a large dataset from the NSDUH (National Survey on Drug Use and Health), and controlling for several demographic and labor market-related variables, our results indicate that legal drug use (for nonmedical reasons) leads to an increase in work absenteeism, as does marijuana. In some instances, legal drug use has a greater effect on work absenteeism that does marijuana.
Modelo de proximidad espacial para definir sitios de muestreo en redes urbanas de calidad de aire

This paper presents a model of spatial proximity to roads, industrial uses of land and green areas, to determine concentrations of particulate matter and locate air quality monitoring sites in urban areas. The model uses monthly average concentration of PM10 (μgm/m3) measured at nine monitoring sites in the city of Medellin between January 2003 and December 2008. With these data, monthly maps were calculated using geostatistical interpolation methods with J-Bessel semivariograms to characterize the concentration of PM10. Three factors of spatial proximity (to main roads, industries and green areas) were calculated along with one combined factor. They were then multiplied by the concentration maps. With this result, a network of monitoring sites was proposed for Medellín. The Spatial analysis techniques and the proximity model allow for the assessment of the distribution of the contaminant on the territory, highlighting the effect of intersections and industrial areas on high concentrations and the dampening effect of green areas. This work may complement the existing regulatory provisions in Colombia for locating critical monitoring sites of the air quality surveillance systems. ----------
Are Our Favorite Drugs Killing the Wrong Bugs? The Impact of Antibiotic Treatment on Diarrhea and Growth in Early Childhood

Background Antibiotics are commonly given for the treatment of childhood diarrhea, but are not indicated in most cases. Antibiotics modify the gastrointestinal microbiota, which may have unanticipated effects on the risk of subsequent diarrhea. Methods In a prospective observational cohort study, we assessed the effect of caregiver-reported antibiotic treatment for diarrhea on the timing of a child’s next episode among 434 children followed from birth to 3 years of age in Vellore, India. We estimated median time differences and time ratios from inverse probability of exposure-weighted Kaplan-Meier curves for the time to next diarrhea episode comparing children who did and did not receive antibiotics for the previous episode. Results Study children had more than 5 diarrhea episodes on average in the first 3 years of life, and more than a quarter of all episodes were treated with antibiotics. Children who received antibiotics for their first diarrhea episode had their second episode on average 8 weeks earlier (median time difference: -8, 95% CI: -10, -3) than children who did not receive antibiotics. The
Características clínicas y sociodemográficas de la población con neoplasias quísticas del páncreas en el hospital universitario mayor entre los años 2010 – 2015

Introduccion: Las neoplasias quisticas son una patologia relativamente nueva, esto debido a que anteriormente no se diagnosticaban. Sin embargo con el advenimiento y desarrollo de las imagenes diagnosticas su incidencia ha aumentado. Aunque la mayoria son asintomaticas, algunas pueden producir sintomas y mas destacable aun, algunas pueden comportarse como una verdadera neoplasia maligna. Metodos: Utilizando un enfoque cuantitativo se describieron las caracteristicas sociodemograficas y clinicas en una serie de casos de pacientes que presentaron neoplasias quisticas del pancreas en el periodo 2010 a 2015 en Mederi HUM. Resultados: La serie descrita es una serie de 34 pacientes que presentaron el diagnostico de neoplasia quistica del pancreas. La edad media de los pacientes fue 68.5 anos y 24 (70.6%) de los casos se presentaron en mujeres. La presentacion clinica predominante al momento del diagnostico fue dolor inespecifico seguida de ictericia. El diagnostico fue realizado por imagenes diagnosticas en el 100% de los casos las cuales se realizaron por diferentes razones, siendo sobresaliente dolor abdominal inespecifico, tambien es importante destacar que en un porcentaje no despreciable de pacientes se encontro como hallazgo incidental (14,7%). La neoplasia quistica mas frecuentemente encontrada en nuestra serie fue la neoplasia papilar intraductal, en segundo lugar el cistoadenoma seroso, posteriormente la neoplasia quistica mucinosa y no se encontro ningun caso de pseudotumor solido. Discusion: Se debe destacar que a pesar de las diferencias encontradas en nuestra serie con la literatura mundial, son mas apreciables las similitudes. A pesar de esto debemos desarrollar protocolos institucionales para un manejo optimo de esta patologia con los recursos disponibles, y ser conscientes de la importancia debido a una incidencia en aumento.
Comparison and Discussion on Shortcircuit Protections for Silicon-Carbide MOSFET Modules: Desaturation Versus Rogowski Switch-Current Sensor

Survivability of silicon-carbide (SiC) mosfet modules during short circuit (SC) is essential for modern power electronics systems due to large economic implications. SiC mosfet modules exhibit narrow SC withstand times and generally much lower SC robustness than silicon (Si) insulated-gate bipolar transistors (IGBTs). This puts a critical concern on their utilization, further stressing the importance of reliable protection. This article presents a comprehensive analysis and discussion on the SiC mosfet module SC protection and performance comparison between conventional desaturation detection, previously used for Si IGBT protection, and Rogowski switch-current sensor (RSCS) detection. In addition, this article presents the experimental design for soft turn-off as a reaction to the SC detection to avoid excessive overshoots during the abrupt turn-off of the SC current. To perform different types of SC with various fault inductances on different temperatures, and for the sake of fair comparison under the same conditions, a gate-driver unit for 1.2 kV SiC mosfet half-bridge modules is developed containing both detection methods. The results demonstrate that both methods are successful in protecting the module in all SC types, with superiority of the RSCS detection and concerns for desaturation detection in high-inductance and high dc-bus voltage SC events.
Linear Quadrupole Magnetic Field Measured with a Smartphone

We believe that a natural focus of the physics education research community is on understanding and improving students’ learning in our physics courses. Due to the increase in technology, we can bring laboratory experiments closer to our students. It is necessary to update our laboratories technologically to get closer to the world in which our students live. With this in mind, we have considered the magnetic field created by a linear quadrupole and we have studied its dependence on distance, n being the exponent of distance. The main objective of this exercise is for our students to discover that the exponent n is very close to –4. The purpose of this work is to show that a laboratory is a powerful tool that increases significant learning under three conditions: 1) the practice must not be too sophisticated; 2) students must handle objects in the lab; and 3) the practice must be scientifically accurate, including the fitting using the least-squares approximation, and the following and necessary error calculation. We provide this practice so that all interested physics teachers can use it and adapt it to their specific laboratory.
Experiences of Officer Cadets in Canadian Military Colleges and Civilian Universities: A Gender Perspective

This study examined gender differences in the experiences of 923 officer cadets attending Canadian Military Colleges and 135 officer cadets attending civilian universities who completed a survey. Overall, the findings revealed that the experience of officer cadets in civilian universities was more positive, gender neutral, and their institutions’ values and culture were a better fit for them compared to their peers in Canadian Military Colleges. For officer cadets in Canadian Military Colleges, the results revealed that women were less likely to perceive gender equality in the way they were treated, the fairness of complaint mechanisms, and being treated with respect compared to men. Men in Canadian Military Collegess were less likely to perceive gender equality in performance standards than women. There were no gender differences in experiences for officer cadets in civilian universities.
Characterisation of objective lung function measures in young children with recurrent wheeze

Background The assessment of lung function, and in particular spirometry, in patients with asthma is routinely used in older children and adults to aid asthma diagnosis and management. However, the assessment of lung function using spirometry is difficult in young children due to their inability to perform acceptable measures. The forced oscillation technique (FOT) requires minimal effort and cooperation and is easy for young children to complete. The clinical utility of FOT in the assessment of baseline lung function, bronchodilator response (BDR) and bronchial hyper-responsiveness (BHR) in young children with asthma has not been well defined and need to be addressed. Aims The aim of this thesis was to evaluate the FOT for the clinical assessment in three to seven years old children with asthma, this specifically involved: 1. The assessment of the relationships between baseline lung function and BDR using the FOT with varying levels of asthma severity and symptoms. 2. Determine the safety and feasibility of the mannitol challenge to assess BHR using FOT in young children. 3. Determine the agreement between mannitol and exercise challenge tests in young children with exercise-induced symptoms using FOT.
Evaluation of Cytotoxic, Oxidative, and Pro-Inflammatory Effects of Aqueous Cigarette Smoke Extract on Human Monocytes: A Potential Model System for Assessment of Next-Generation Tobacco and Nicotine Products

Abstract Tobacco smoking is a risk factor for the development of atherosclerosis. One strategy to reduce the harmful side effects of tobacco smoking is the development of next-generation tobacco and nicotine products. A crucial step in the development of atherosclerosis is the activation and adhesion of monocytes. Remarkably, little is known about the direct effects of cigarette smoking on monocytes. In this study, we developed methods to determine the detrimental effects of aqueous cigarette smoke extract (CSEaq) from 3R4F reference cigarettes on human monocytes in vitro. First, we tested the cytotoxic effects of CSEaq on human peripheral blood monocyte cell line derived from an acute monocytic leukemia patient (THP-1) and primary monocytes. Treatment of THP-1 cells with CSEaq reduced cell viability at dosages ≥40% in a dose-dependent manner. Cell viability of primary monocytes was reduced by CSEaq at dosages ≥10%. CSEaq activated the antioxidative NRF2 system and its target gene NAD(P)H dehydrogenase, q.
Diagnosis of Dementia-Circadian Dependency?

Little is known whether tests used for the diagnosis of dementia syndromes are sensitive to time of day effects. In a sample of 145 participants, no such effect (test administration either in the morning from 9.30 to 11.30 a.m. or in the afternoon from 2.30 to 4.30 p.m.) could be found for most subtests of a neurocognitive test battery (CERAD-Plus) used for the detection of dementia syndromes. However, for subjects suffering from mild cognitive impairment, completion time for the Trail-Making Test B, a brief cognitive test for the assessment of cognitive flexibility, was longer in the afternoon compared to the morning.
Sí, Pero no Aquí: Percepciones de xenofobia y discriminación hacia migrantes de Venezuela en Colombia, Ecuador y Perú

Mas de 4,4 millones de personas han salido de Venezuela como consecuencia de una prolongada crisis economica, politica y social: 2,8 millones de ellas hacia otros paises de Latinoamerica y el Caribe, en especial Colombia, Peru y Ecuador. Mientras, mas de 7 millones de personas permanecen en el pais con necesidades de asistencia humanitaria y proteccion. Entre febrero y julio de 2019, Oxfam llevo a cabo un estudio que ayuda a comprender mejor las percepciones, emociones y actitudes que, con respecto a la migracion venezolana, experimentan las personas en Colombia, Ecuador y Peru, y como se expone a narrativas xenofobas, machistas y estereotipadas a las personas llegadas desde Venezuela. Este informe analiza y revela en particular las percepciones y miedos que alimentan posturas xenofobas, sexistas y discriminatorias frente a la migracion, al tiempo que alienta una accion comunicativa y de politicas publicas responsable, proactiva y humana, basada en evidencias y en derechos fundamentales, ante los flujos migratorios en la region.