Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy and Safety of the Oral Neuraminidase Inhibitor Oseltamivir in Treating Acute Influenza

ContextPrevious studies have shown oseltamivir, a neuraminidase inhibitor, to be effective in preventing influenza and treating experimental influenza.ObjectiveTo evaluate the efficacy and safety of oseltamivir in the treatment of naturally acquired influenza infection.DesignRandomized, placebo-controlled, double-blind study conducted January through March 1998.SettingSixty primary care and university health centers throughout the United States.ParticipantsA total of 629 healthy nonimmunized adults aged 18 to 65 years with febrile respiratory illness of no more than 36 hours' duration with temperature of 38°C or more plus at least 1 respiratory symptom and 1 constitutional symptom.InterventionsIndividuals were randomized to 1 of 3 treatment groups with identical appearing pills: oral oseltamivir phosphate, 75 mg twice daily (n = 211) or 150 mg (n = 209) twice daily, or placebo (n = 209). Main Outcome MeasuresDuration and severity of illness in individuals infected with influenza.ResultsTwo individuals withdrew before receiving medication and were excluded from further analyses. A total of 374 individuals (59.6%) were infected with influenza. Their duration of illness was reduced by more than 30% with both oseltamivir, 75 mg twice daily (median, 71.5 hours; P<.001), and oseltamivir, 150 mg twice daily (median, 69.9 hours; P = .006), compared with placebo (median, 103.3 hours). Severity of illness was reduced by 38% (median score, 597 score-hours; P<.001) with oseltamivir, 75 mg twice daily, and by 35% (median score, 626 score-hours; P<.001) with oseltamivir, 150 mg twice daily, vs placebo (median score, 963 score-hours). Oseltamivir treatment reduced the duration of fever and oseltamivir recipients returned to usual activities 2 to 3 days earlier than placebo recipients (P≤.05). Secondary complications such as bronchitis and sinusitis occurred in 15% of placebo recipients compared with 7% of combined oseltamivir recipients (P = .03). Among all 629 subjects, oseltamivir reduced illness duration (76.3 hours and 74.3 hours for 75 mg and 150 mg, respectively, vs 97.0 hours for placebo; P = .004 for both comparisons) and illness severity (686 score-hours and 629 score-hours for 75 mg and 150 mg, respectively, vs 887 score-hours for placebo; P<.001 for both comparisons). Nausea and vomiting occurred more frequently in both oseltamivir groups (combined, 18.0% and 14.1%, respectively; P = .002) than in the placebo group (7.4% and 3.4%; P<.001). ConclusionsOur data suggest that oral oseltamivir treatment reduces the duration and severity of acute influenza in healthy adults and may decrease the incidence of secondary complications.
PENGARUH KEPUASAN DAN KEPERCAYAAN PELANGGAN TERHADAP LOYALITAS PELANGGAN AUTO 2000 SUNGKONO SURABAYA

Currently, the tight competition in the car repair shop business has made business practitioners in this field try hard to maintain their existence including the Auto 2000 Car Repair Shop Sungkono Branch Surabaya. One of the ways is to create the customer loyalty.This research is meant to analyze the influence of customer satisfaction and customer trust to the customer loyalty at Auto 2000 Car Repair Shop Sungkono Branch Surabaya. This research has been done by using purposive sampling technique and 100 respondentswhoare the customers that have ever used maintenance service of Toyota vehicle and its warranty period has expired. Meanwhile, the data analysis technique has been done by using multiple regressions analysis with the instrument of SPSS. The indicators of customer satisfaction i.e.: Confirmation ofexpectations, re-purchase interests andoverallcustomersatisfaction. And the indicators of customer trust are: integrity perception, good perception and competency perception.The result of this research states that customer satisfaction and customer trust have positive influence to the customer loyalty both regressions model or even the partial hypothesis test. And it has been found that the dominant in influencing customer loyalty in this research is customers satisfaction. Keywords: Customer Satisfaction, Customer Trust, Customer Loyalty.
The effect of reduced alcohol consumption on blood pressure: a randomised, controlled, single blind study.

A randomised, controlled, single blind trial was conducted in office workers with mild hypertension (systolic blood pressure (SBP) 140 to 180 mmHg, diastolic blood pressure (DBP) 90 to 110 mmHg) to determine the effect of decreasing alcohol consumption. After a baseline examination, 50 male volunteers aged 30 to 59 were randomised to two groups. Group A were told to abstain from or reduce alcohol consumption for two weeks, while group B were instructed to maintain their usual alcohol consumption. Complete records were obtained on 49 subjects. The daily alcohol consumption of groups A and B at baseline was similar, i.e. 71.9 ml and 72.5 ml of ethanol, respectively, and changed to 16.1 ml and 62.9 ml, respectively, during the experiment. After two weeks, group A were asked to resume their normal consumption whilst group B were asked to reduce or abstain (phase II). However in view of a treatment period interaction, statistical analysis was confined to phase I. During phase I, group A, whose alcohol consumption had reduced, showed decreases of 5.8 and 7.1 mmHg in SBP during the the first and second weeks, respectively. In group B, these decreases were only 0.6 and 1.9 mmHg, respectively. The difference between the falls in SBP in groups A and B was significant (P = 0.005) as judged by analysis of variance. The DBP also decreased, but there was no significant difference between the decreases in the two groups. Changes in gamma-glutamyl-transpeptidase, a biochemical marker of alcohol consumption, from the initial values to the end of phase I were significantly different in groups A and B. (ABSTRACT TRUNCATED AT 250 WORDS)
Production and Characterization of Monoclonal Antibodies to Psittacine Beak and Feather Disease Virus

Monoclonal antibodies specific for the virus that causes psittacine beak and feather disease (PBFD) were produced by fusing spleen cells from mice immunized with purified concentrated PBFD virus with mouse myeloma cell line Sp2/0. The resulting hybridomas were tested for reactivity against whole purified virus by an enzyme-linked immunosorbent assay (ELISA) system. Four clones, designated 15H8, 8E3, 11G12, and 2C3, were subcloned by limiting dilution. Isotyping indicated that clone 15H8 was secreting IgG, whereas the remaining clones secreted IgM. The secreted immunoglobulins were characterized by reactivity against purified PBFD virus using immunoblotting procedures, by immunohistochemical staining of virus-induced lesions in infected tissues, and by inhibition of PBFD virus agglutination of cockatoo erythrocytes. Antibodies secreted by clones 15H8 and 8E3 had the strongest activity against purified whole virus. Only immunoglobulin secreted by the clone 15H8 could be used to detect viral antigen in infected tissues. None of the monoclonal antibodies had hemagglutination-inhibition activity.
Usability assessment of web interfaces: User Testing

The assessment of the usability aims to identify specific problems on the interface it is a process which uses several techniques and methods. One of those techniques the user testing is here shown through the completion of a set of tasks that aims to observe and measure the user's interaction with the interface. In the case presented the user Testing was built based on a sequence of interviews with real and representative users of the community which uses the Website. From this came the definition of several profiles, with the three most relevant profiles being posteriorly selected for one set of ten tasks. Three open questions were additionally included which, along the comments made by the participants during the user Testing permitted to obtain subjective information as it is the user's satisfaction assessment. The results obtained were very clear as they indicated that the Website's usability is quite reasonable, that is, in general, the users execute their tasks with ease, speed and satisfaction.
Cushion form Bearings for Total Knee Joint Replacement Part 2: Wear and Durability

Cushion knee prostheses have been designed and constructed to produce larger initial contact areas and thicker theoretical film thicknesses than a conventional UHMWPE (ultra-high molecular weight polyethylene) joint. The compliant bearing had a flat tibial component which imposed fewer biomechanical constraints and allowed greater range of movement. Wear tests were performed in a knee joint simulator and creep tests were carried out in a servo-hydraulic apparatus. Various failure modes of cushion joints that require further study were identified. However, the results showed that adequate durability was achieved from a 20 MPa polyurethane material in joint simulating tests carried out over 0.5, 1.0 and 5.0 million cycles. Most importantly, during these tests, no detectable wear debris was generated. It is believed that this is the first time that the full potential of cushion bearings has been demonstrated in a joint simulator over periods corresponding to about five years of service in vivo.
De Rham Cohomology and Hodge Decomposition For Quantum Groups

Let Γ=Γτ,z be one of the N2‐dimensional bicovariant first order differential calculi for the quantum groups GLq(N), SLq(N), SOq(N), or Spq(N), where q is a transcendental complex number and z is a regular parameter. It is shown that the de Rham cohomology of Woronowicz' external algebra Γ∧ coincides with the de Rham cohomologies of its left‐coinvariant, its right‐coinvariant and its (two‐sided) coinvariant subcomplexes. In the cases GLq(N) and SLq(N) the cohomology ring is isomorphic to the coinvariant external algebra ΓInv∧ and to the vector space of harmonic forms. We prove a Hodge decomposition theorem in these cases. The main technical tool is the spectral decomposition of the quantum Laplace‐Beltrami operator. 2000 Mathematical Subject Classification: 46L87, 58A12, 81R50.
A discontinuous PWM scheme for lowering the switching frequency and losses in a 3-phase 6-switch 3/5-level PWM VSI using a 3-limb inductor

Standard interleaved 3-level pwm schemes used in multilevel 3-phase inverters such as the NPC are shown not to be suitable for multi-level inverters using a 3-limb coupled inductor. This paper illustrates how a standard discontinuous 3-level pwm scheme can be modified to provide an appropriate excitation for a 3/5 level 6-switch coupled inductor inverter (CII). The pwm reference signals and switching patterns are chosen to excite the inductor phase windings so that only 3 high permeability flux paths in the inductor core are used. As a result, the high frequency current ripple in the inductor windings are reduced together with the high frequency flux produced in the core. The resultant inverter operation can be operated at much lower switching frequencies (2-8 kHz), and levels that are more suitable for standard industrial applications. Experimental results illustrate that the new pwm scheme improves the efficiency of the inverter and lowers the power losses in the coupled inductor. The lower inductor losses also means that the physical size of the coupled inductor can be reduced. Experimental and simulated results are used to demonstrate the operation of the new pwm scheme using a variable speed inverter drive.
Sparse multi-level representations for text retrieval

In text retrieval, our task is to find the subset of a collection of natural language documents that is relevant to a query. The popular Vector Space Model (VSM) treats documents and queries as a vector of word counts, defining relevance as the dot product of two vectors--a measure of the number of common terms. Although both space and time-efficient, VSM ignores a great deal of the natural structure in text. Further, VSM suffers because the presence or absence of a term is not sufficient to determine relevance. Typical machine learning extensions to VSM use linear dimensionality reduction to extract underlying structure. We show that a popular family of dimensionality reduction techniques induces a distribution over documents of a form that can be very different from the "optimal" distribution induced when clusters of related documents are known beforehand. We characterize the form of the optimal distribution, drawing connections to independent components, and projection pursuit. We then derive an unsupervised method that approximate characteristics of this distribution. They are topic-centered in that they construct a new space whose axes represent clusters of highly-related terms. In all of these techniques, we are able to reject candidate axes as unsuitable by using kurtosis as a measure of "interestingness," improving retrieval performance. Further, we address the common assumption that queries and documents should be treated as if they live in the same vector space. Rather than accept this wholesale, we construct a multi-level representation of documents using an efficient statistical procedure and simple natural language parsing. Each level of the representation contains different features that embody increasingly more general natural language structure. These features are used to classify queries of varying structural richness. Once classified, a query is matched against a representation of documents that reflects its structure. Finally, we deal with the computational issues that arise with the extremely large data sets used in real-world retrieval. In particular, we describe Brazil, a research system custom-designed for retrieval on extremely large data sets. This system is based on the Parallel Problems Server, an extremely powerful and novel parallel "linear algebra server" that we have developed. Using this system, we show that our techniques improve retrieval performance and can be realized through algorithms that are space and time efficient. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)
The Costs and Benefits of Public Oversight Design: Evidence from the EU

We examine the audit pricing and audit quality consequences of three public oversight design features: a) membership; b) powers; and c) the content of inspection reports. We hand-collect a new dataset covering 24 EU countries and we document significant variation in the design of public oversight systems across the EU. Further, using a large sample of listed firms during 2005-2013 we report a significant increase in audit fees when auditor oversight is performed only by non-practitioners, who are potentially more independent and objective, or by regulators with higher enforcement power, who are potentially more efficient. However, based on methodologies used in extant archival studies we do not provide any evidence suggesting that audit quality varies across alternative public oversight systems. Overall, our study provides evidence regarding the effect of different public oversight designs on audit fees and audit quality, including the long-standing debate about the merits of monitoring by experienced practitioners vs. monitoring by independent non-practitioners.
Effects of Symbolic Verbalization by the Model on Children's Observational Learning

Two experiments on the effects of symbolic verbalization by a model upon children's recall of the model's responses for a series of dichotomous choices were conducted. As expected, Exp. I, conducted with first grade children, showed that such verbalizations did significantly improve imitative recall although this influence did not extend to a second block of trials in which the verbalizations were no longer provided. Exp. II, with preschool children, again showed a facilitating effect for symbolic verbalizations.
Correlation of toxicity with pharmacokinetics of pegylated liposomal doxorubicin (Doxil) in metastatic breast carcinoma

Doxil (ALZA Corp., Mountain View, CA) is a formulation of doxorubicin in polyethylene‐glycol coated liposomes with a prolonged circulation time and unique toxicity profile. As yet, the effect of the dose schedule on toxicity and the correlation of toxicity with pharmacokinetics have not been directly addressed.
Cloud-based model predictive building thermostatic controls of commercial buildings: Algorithm and implementation

The contribution of this paper is in two-folds: 1) If more predictive and intelligent control of the thermostat setpoints with no explicit models of Root Top Units (RTUs) yet with simplistic lumped parameter thermal models of buildings can be effective in reducing a small commercial buildings summer-time peak load while adequately maintaining comfort levels, and 2) how this simplistic indirect control approach to RTUs compare to more sophisticated direct control approaches in terms of peak-load reduction and cost. First, the model-predictive control approach is presented. Second, the results of cloud-based implementation of the optimization algorithm at the two demonstration commercial buildings owned by General Electric (GE), optimizer characteristics, different set point trajectories and their implication with regards to peak load and comfort, and observations are described. On average, the savings from the indirect optimal control strategy utilized in our approach through a cloud-based control implementation architecture is shown to be comparable to previously stated savings in literature from more sophisticated direct optimal control of RTUs while the comfort levels are the same as the non-optimal strategy or slightly better in some cases.
Hamartoma of the Breast in a Man: First Case Report

Abstract: Mammary hamartomas were reported in 0.7% of all benign tumors of the female breast. Histologically breast hamartomas contain lobular breast tissue with various degrees of fibrous, fibrocystic, and adipose tissue. Rare types include muscular (myoid) and cartilage (chondroid) hamartomas. We report a case of muscular hamartoma in a man. A 36‐year‐old man was admitted to the psychiatric unit with the diagnosis of schizophrenia. The patient complained of a slowly growing mass in his left breast. He denied any discharge from the nipple, but he complained of itching. A 2 cm × 3 cm nontender mass was palpable. There was no evidence of axillary lymphadenopathy. A needle aspiration was nondiagnostic. The excisional biopsy specimen revealed fatty tissue which was edematous and hemorrhagic. Microscopically it showed multiple bundles of muscles organized randomly. Myoid hamartoma was the diagnosis. Mammary hamartoma is considered a female tumor exclusively. Myoid hamartoma has been reported previously in 25 women. We report a myoid hamartoma in a man and, to our knowledge, it is the first and only such case to be reported.
Efficiently Constraining Climate Sensitivity with Ensembles of Paleoclimate Simulations

We use a recently-developed efficient probabilistic estimation technique to estimate the sensitivity of the Earth’s temperature to a doubling of atmospheric carbon dioxide. The method is based on the ensemble Kalman filter which we apply to the CCSR/NIES/ FRCGC AGCM (the atmospheric component of MIROC 3.2) at T21L20 resolution coupled to a slab ocean. The method combines prior beliefs about the model, with observational data, to simultaneously estimate 25 model parameters in an efficient and objective manner. We perform a sensitivity analysis to investigate the effect of different assumptions regarding model error, since this is a necessarily subjective input which has not yet been well characterised. We attempt to validate the resulting ensembles against out-of-sample data by comparing their hindcasts of the Last Glacial Maximum (LGM) to paleoclimate proxy data, and demonstrate through this that our ensembles of simulations are probably biased towards too high a sensitivity. Within the framework of our single-model ensemble experiment, we show that climate sensitivity of much greater than 6° Ci s hard to reconcile with the paleoclimate record, and that of greater than 8°C seems virtually impossible. Our estimate for the most likely climate sensitivity is in the region of 4.5°C. Although these results are reasonably consistent with the most widely accepted estimates of climate sensitivity, they disagree with some recent research which has suggested a significant probability of sensitivities well in excess of these values. These results suggest that paleoclimatic evidence could provide a useful, albeit imprecise, constraint on ensemble forecasts of future climate change.
Consecutive Lacunar Strokes Mimicking Brainstem Symptoms in a Patient With Pseudobulbar Palsy.

BACKGROUND The pseudobulbar palsy affects both corticobulbar tracts leading to symptoms of the caudal brain nerves. These bulbar symptoms often may be misinterpreted and lead to a false localization of the ischemic lesion. Here we report on a patient with an acute small lacunar ischemic lesion who presented clinically with severe affection because of an identical old contralateral lesion. CASE REPORT The patient presented with sudden onset of dysphagia, anarthria, and glossplegia. The clinical examination was suspicious of a brainstem lesion, however, stroke magnetic resonance imaging revealed a small ischemic lacuna within the right internal capsule. However, because of an old ischemic lesion within the left internal capsule, both corticobulbar tracts were involved and this pseudobulbar palsy was mimicking bulbar brainstem symptoms. DISCUSSION Patients who suffer from a pseudobulbar palsy usually have—compared with the rather small lesions within the central nervous system—clinically dramatic presentations and due to bulbar symptoms severe medical secondary complications and social-economic consequences to deal with.
Baumarkt 2.0. Do-It-Yourself, Youtube und die Digital Natives

Owing to computers and Internet we live in a highly engeneered and interlaced world today. Into all ranges of our daily life the digitality has meanwhile taken introduction, also into the most intimate corners. We contact our friends via Facebook, settle banking transactions by Online-Banking and watch for Youtube, as the new desk can be assembled best. Do-It-Yourself – a meanwhile nearly 60 years old movement – is closed to a virtual revolution. Who would like to understand that should know what words such as Cocooning, Digital Native or Community denote in future.
A potential role of ruxolitinib in leukemia

Introduction: An increased understanding of cellular signaling pathways, like the JAK–STAT pathway, and the identification of the JAK2 V617F mutation in the classic Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), has generated great interest in the development of targeted JAK2 inhibitors. In a recently completed Phase I–II study, ruxolitinib, a selective orally available JAK1 and JAK2 inhibitor, has shown efficacy in patients with advanced myelofibrosis. Constitutive activation of the JAK–STAT pathway has also been implicated in other hematological malignancies suggesting a potential role of JAK kinase inhibitors in these malignancies. Areas covered: This article reviews the chemistry, pharmacodynamics, pharmacokinetics, clinical efficacy, safety and tolerability of ruxolitinib. The literature for this article was retrieved from PubMed database searches using the keywords ‘ruxolitinib’, ‘INCB 018424’, ‘JAK2 inhibitors’ and ‘leukemia’. Expert opinion: The JAK–STAT signaling pathway plays a vital role in leukemogenesis. Ruxolitinib, a potent JAK1 and JAK2 inhibitor, known to decrease spleen size and alleviate constitutional symptoms in myelofibrosis, represents a potentially promising agent for the treatment of leukemias by inhibiting the JAK–STAT signaling. Further studies of ruxolitinib, in patients with acute and chronic leukemias, are now needed to establish the clinical usefulness of this promising drug.