Miracle-dz/UniFAR-FTUs huggingface dataset:
Explorations with Heterogeneous Access Patterns

The size and scope of cutting-edge scientific simulations are growing much faster than the I/O and storage capabilities of their run-time environments. The growing gap is exacerbated by exploratory, data–intensive analytics, such as querying simulation data with multivariate, spatio-temporal constraints, which induces heterogeneous access patterns that stress the performance of the underlying storage system. Previous work addresses data layout and indexing techniques to improve query performance for a single access pattern, which is not sufficient for complex analytics jobs. We present PARLO a parallel run-time layout optimization framework, to achieve multi-level data layout optimization for scientific applications at run-time before data is written to storage. The layout schemes optimize for heterogeneous access patterns with user-specified priorities. PARLO is integrated with ADIOS, a high-performance parallel I/O middleware for large-scale HPC applications, to achieve user-transparent, light-weight layout optimization for scientific datasets. It offers simple XML-based configuration for users to achieve flexible layout optimization without the need to modify or recompile application codes. Experiments show that PARLO improves performance by 2 to 26 times for queries with heterogeneous access patterns compared to state-of-the-art scientific database management systems. Compared to traditional post-processing approaches, its underlying run-time layout optimization achieves a 56% savings in processing time and a reduction in storage overhead of up to 50%. PARLO also exhibits a low run-time resource requirement, while also limiting the performance impact on running applications to a reasonable level.
The Klippel–Trenaunay syndrome: Clinical, radiological and haemodynamic features and management

Forty‐nine patients with the Klippel‐Trenaunay syndrome have been studied. Sixty‐eight per cent have a superficial, embryological venous channel on the lateral aspect of the limb, 25 per cent have had one or more severe spontaneous haemorrhages from dilated varices and 22 per cent have suffered a venous thrombo‐embolism. Twenty‐nine per cent have had episodes of rectal bleeding or haematuria associated with pelvic angiomas. Foot volumetry (n = 31) showed that calf emptying was decreased in only five patients and only one of these had phlebographic evidence of deep venous obstruction, which conflicts with previous findings. The rate of calf refilling was increased in 81 per cent and phlebography demonstrated incompetent communicating veins in 45 per cent of patients. No patient had clinical evidence of an arteriovenous fistula, and arteriography (n = 22) and calf blood flow (n = 33) were normal, but lymphangiography (n = 14) showed lymphatic hypoplasia in 55 per cent of limbs. Eighty‐eight operations have been performed on 38 patients but symptoms persist in 90 per cent. We suggest that surgery should be limited to the excision of localized symptomatic abnormalities and that the best form of control is provided by graduated compression stockings.
Study of anaemia amongst OPD patients visiting a private medical college in Lucknow, Uttar Pradesh

Introduction: Anaemia is multi factorial with widespread negative consequences on health. It is more common in developing countries. It has a negative influence on the social and economic development of country. Materials and Methods: This study included 211 anaemic and 174 non anaemic subjects. Age, gender, socio economic status, dietary habits and education was enquired about and haematological parameters were analysed. Data was analysed using appropriate tests. Results: 54.8% patients attending OPD’s were found to be anaemic. It was higher in females (65%) than males (41.2%). As per WHO classification mild, moderate and severe anaemia was present in 54.98%, 37.91% and 7.11% subjects respectively. 63.99% anaemic subjects belonged to upper to middle class and 36.01% belonged to lower middle and lower class. Anaemia was higher in subjects belonging to middle to lower classes and those belonging to low education class like high school to illiterate class. Not much difference was found on the basis of dietary preferences. However the percentage of anaemic subjects with mixed dietary habits was slightly higher. Conclusion: On the basis of study it may be concluded that amongst OPD patient’s gender, socioeconomic status and education play role directly or indirectly in anaemia. Keywords: Anaemia, Socio economic, Education, Diet, Gender, OPD’s.
Aspirin and proton-pump inhibitors: interpreting the interplay.

This editorial refers to ‘Proton pump inhibitor use by aspirin-treated coronary artery disease patients is not associated with increased risk of cardiovascular events’, by L.A. Fortuna et al . doi:10.1093/ehjcvp/pvv036 Aspirin has a well-established role in secondary prevention of cardiovascular disease, but increases gastrointestinal bleeding, especially when used in high-risk patients. Unfortunately, gastrointestinal bleeding in patients after acute coronary syndrome portends poor prognosis and is independently associated with increased risk for adverse cardiovascular events and mortality.1 Proton-pump inhibitors (PPIs) have been shown to effectively reduce the risk of gastrointestinal bleeding in patients requiring dual antiplatelet therapy (DAPT)2 and may improve aspirin adherence due to reduction in dyspepsia.3,4 Multidisciplinary consensus guidelines thus recommend the prophylactic use of PPIs in high-risk patients requiring antiplatelet therapy.5 However, there has been growing interest in possible adverse drug interactions between aspirin and PPIs compromising the antiplatelet efficacy of aspirin. Early preclinical data have supported a potential pharmacologic interaction between these widely-prescribed agents, but limited clinical data have substantiated this theoretical posit. Prior work had suggested that PPIs may attenuate gastric absorption of aspirin based on preclinical data. Co-administration of PPIs with aspirin in rat models increased gastric pH, reduced the lipophilicity and oral bioavailability of aspirin, and enhanced inactivation of aspirin to salicylate metabolites.6 Two subsequent ex vivo platelet function studies provided …
Recent Advances in Diagnostic Colonoscopy for Colorectal Cancer Screening: An Update for Radiologists.

OBJECTIVE Colonoscopy accuracy in detecting colorectal neoplasia is critical for colorectal cancer prevention but has been shown to be operator- and technology-dependent. This article will discuss several recent improvements in the technique and technology of colonoscopy. CONCLUSION More rigorous training and retraining programs, active monitoring of endoscopist technique and outcomes, and exclusion of poorly performing endoscopists are urgently needed to improve the ultimate efficacy of colorectal cancer screening programs.
Spatial-Temporal Behavior Analysis Using Big Data Acquired by Wi-Fi Indoor Positioning System

Understanding of people’s spatial behavior is fundamental to architectural and urban design. However, traditional investigation methods applied in environmental behavior studies is highly limited regarding the amount of samples and regions it covers, which is not sufficient for the exploration of complex dynamic human behaviors and social activities in architectural space. Only recently the developments in indoor positioning system (IPS) and big data analysis technique have made it possible to conduct a full-time, full-coverage study on human environmental behavior. Among the variety IPS systems, the Wi-Fi IPS system is increasingly widely used because it is easy to be applied with acceptable cost. In this paper, we analyzed a 60-days anonymized data set, collected by aWi-Fi IPS system with 110Wi-Fi access points. The analysis revealed interesting patterns on people’s behavior besides temporal spatial distribution, ranging from the cyclical fluctuation in human flow to behavioral patterns of sub-regions, some of which are not easy to be identified and interpreted by the traditional field observation. Through this case study, behavioral data from IPS system has exhibited great potential in bringing about profound changes in the study of environmental behavior.
THE PREVALENCE OF MALARIA INFECTION AMONG SECONDARY SCHOOL STUDENTS IN OBA IDEMILI SOUTH LOCAL GOVERNMENT AREA, ANAMBRA STATE NIGERIA

A cross sectional study on the prevalence of malaria infection among secondary school students in Oba Idemil South Local Government Area Anambra State, Nigeria was carried out between January and April 2009. A total of 300 students (161 males and 139 females) were involved in the study. Venous blood containing Ethylene Diamine Tetra acetic Acid (EDTA) of the 300 students was screened for malaria parasites using Giemsa-stained thick and thin blood films. Of the 300 blood samples examined, 31 (10.3%) were positive for malaria parasite. Plasmodium falciparum was identified in all the positive cases. Prevalence rate of 16 (9.9%) was recorded in males while prevalence rate in females was 15 (10.8%); this difference was not statistically significant (p=0.809, p> 0.05). The private schools recorded a higher prevalence 23(13.5%) than the public schools 8(6.2%); this difference was statistically significant (p=0.026, p< 0.05). The findings of this study emphasize the need for health education in school, churches and community in order to control malaria in the area. South American Journal of Public Health, Volume-3, Issue-2, 2015
Comparing the Characteristics of Amniotic Membrane-, Endometrium-, and Urinary-Derived ECMs and Their Effects on Endometrial Regeneration in a Rat Uterine Injury Model

Graphical Abstract Overall experimental design scheme. The decellularized extracellular matrices (d-ECMs) currently utilized to repair endometrial injuries are derived from three tissue sources, the endometrium (dE-ECM), placental amniotic membrane (dA-ECM), and urinary (dU-ECM). Notably, the structures of dU-ECM and dE-ECM are similar. These d-ECMs are derived from different tissues, and their specific roles in endometrial injury repair remain unclear. This study aimed to analyse the characteristics of the tissue microstructures and compositions to confirm specific differences among the three ECM types. And using a rat model of endometrial injury, the effects of all the matrices after implantation in vivo on the promotion of endometrial regeneration were analysed. After decellularization, dE-ECM had more residual active factors than the other two ECM types, while dA-ECM had significantly less DNA, α-Gal antigen components and extracellular matrix components than the other two groups. Although the three ECMs had no effect on the proliferation of stromal cells in vitro, dA-ECM may have increased the sensitivity of stromal cells to oestradiol (E2) responses. In vivo experiments confirmed the promotional effect of dA-ECM on endometrial regeneration. For example, the endometrial thickness, collagen deposition, endometrial tissue regeneration, vascular regeneration and pregnancy outcomes were significantly better in this group than in the other two groups. These findings might be associated with the excellent immune tolerance of dA-ECM. Therefore, when selecting a d-ECM for the treatment of endometrial injury, dE-ECM, which has the strongest tissue specificity, is not the preferred choice. Controlling the inflammatory responses in local lesions at the early stage may be a prerequisite for ECMs to exert their functions.
Fundamental-Mode Leaky-Wave Antenna (LWA) Using Slotline and Split-Ring-Resonator (SRR)-Based Metamaterials

A new composite right/left-handed (CRLH) slotline leaky-wave antenna (LWA) is proposed. The antenna, implemented by loading a slotline with split-ring resonators (SRRs), is designed to exhibit a balanced dispersion relation, with a continuous transition between the left-handed and the right-handed bands at 2.5 GHz. Since the periodicity of the structure is much less than a wavelength, the proposed LWA belongs to the family of quasi-uniform LWAs, and it radiates from the fundamental mode (contrary to periodic LWAs). Measured and simulated radiation patterns, gain, and scanning angle are reported for a 17-cell LWA. The experimental results demonstrate the potential of the LWA to continuously radiate from backward (- 50°) to forward (+60°) scanning angles, with maximum gains of 7.1 and 11.3 dB in the left- and right-handed bands, respectively, and specular radiation patterns.
The " Brexit " process understood under neofunctionalist and intergovernmentalist theories of European Integration

Resumen The concepts of contemporary political crisis and European integration cannot be separated from the recent phenomenon of the British intention to leave the framework of the EU. This undertaking was materialized in a referendum. If the Brexit procedure is a new one and generally understood as a crisis of a system, theories of European integration have long debated issues such as this one. Therefore, we will observe the writings of theorists and politicians such as Ernst Haas, Jean Monnet, Denis de Rougemont, Leon Lindberg or Sergio Pistone commonly known as Federalists, Europeanists or Neofunctionalists and comparatively analyze them with the theories of Moravcsik, Alan Milward, Frances Lynch who are known as Intergovernmentalists. This paper will thus serve as a descriptive study of a revision of literature genre. We will be able to observe that the "Brexit" phenomenon brings new difficulties but also theoretical and legal problems that have been experienced and debated in the past. If Europeanists will tend to consider the "Brexit" procedure as a mere setback in a trajectory that will nevertheless lead to a federated Europe, the intergovernmentalists will see it as a sovereign decision taken by a state to redesign its position among this European system of power delegation. After this study, we will be able to observe in what ways is the "Brexit" procedure a new kind of event and how it fits into the history of European integration but also how would several theorists and politicians have debated such events. The "Brexit" process understood under neofunctionalist and intergovernmentalist theories of European Integration. The results of the referendum held on the 23 of June 2016 in the United Kingdom on whether this country ought to remain in the European Union (EU) or not, was met with great surprise all over the world as the results pointed to the effective desire of the British people to leave this political and economic union. 51,89% of the British citizens, therefore a majority of the population, gave the British government(s) the popular vote, through democratic procedures, to start the formal procedures for exiting this Union. Besides the 73 British Members of the European Parliament (MEP’s), the United Kingdom and the EU will also lose the British Commissioner as each country of the EU traditionally has one European Commissioner (although these positioning has changed occasionally and will change in the future). The Article 50 of the Lisbon Treaty (Treaty on the Functioning of the European Union), the necessary and existing legal mechanism for the exit from this Union, is what provides Member States with the legal framework for such an exit, however, article 49, is also important as it provides the framework for a joining or rejoining of a country into the EU’s political space:
the clinical impact of antegrade pulmonary blood flow on the bidirectional cavopulmonary shunt in infants

the bidirectional cavopulmonary anastomosis is commonly used in the palliation of patients with a functionally univentricular physiology. the management of alternative sources of flow of blood to the lungs, as well as the magnitude of acceptable accessory blood flow at the time of surgery, nonetheless, remains controversial. these issues are particularly significant when a cavopulmonary anastomosis is performed in infants who may become candidates for a fontan procedure. indeed, a long-standing volume overload, which is invariably associated with the maintenance of accessory sources of pulmonary blood flow, may result in systemic ventricular dysfunction. these observations prompted us to review the influence of antegrade pulmonary blood flow in the management of infants undergoing a cavopulmonary anastomosis.
Design And Implementation Of Efficient FFT Processor Using Modular Multiplier

Algorithmic Based Fault Tolerance (ABFT) technique utilizes the algorithmic properties for detecting and correcting the errors. FFTs are the key building blocks in many communication and signal processing systems. An efficient conflict-free address scheme for arbitrary point memory-based fast Fourier transform (FFT) processor was exhibited in this paper. In the proposed scheme, a high radix decomposition method was utilized to reduce the computation levels and small radix connected multipathdelay-commutator butterfly units were adopted to eliminate the complexity of the computation engine as well. Several important functions of memory-based FFT processor were combined together, including the continuous-flow mode, variable computation size and conflict-free address scheme. Moreover, a prime factor algorithm was employed to decrease the multiplications and the twiddle factor storage when there subsist prime factors in the decomposition
Structural , Dielectric and Electric Properties of Manganese-Doped Barium Titanate

The Dielectric, Electric Properties and Microstructure of Ba Mnx Ti1-x O3 (where x = 0.0, 0.01, 0.02, 0.03, 0.04) ceramics have been investigated. The ceramic samples were prepared by Solid-State Reaction Method. The SEM microstructure shows grain size decreased from 192.93 nm down to 167.05 nm. Tetragonal structure was found for samples 0.03% and 0.04% Mn-doped BaTiO3 while others showed pseudo-cubic structure. The Dielectric Constant measurements were executed as a function of temperature. Pure and 0.03% Mndoped ceramics showed improved dielectric constant around Curie temperature region. The temperature dependence of electrical resistivity for all samples were noted acquired that the resistivity changes with the addition of Mn+3 ions in the conduction process accordingly, except pure barium titanate i.e, x=0.0.
Offline Localization New Dataset Add Rich Session Summarization Add Observation Session Localizes “ well ” ?

We present a complete map management process for a visual localization system designed for multi-vehicle longterm operations in resource constrained outdoor environments. Outdoor visual localization generates large amounts of data that need to be incorporated into a lifelong visual map in order to allow localization at all times and under all appearance conditions. Processing these large quantities of data is nontrivial, as it is subject to limited computational and storage capabilities both on the vehicle and on the mapping backend. We address this problem with a two-fold map update paradigm capable of, either, adding new visual cues to the map, or updating co-observation statistics. The former, in combination with offline map summarization techniques, allows enhancing the appearance coverage of the lifelong map while keeping the map size limited. On the other hand, the latter is able to significantly boost the appearance-based landmark selection for efficient online localization without incurring any additional computational or storage burden. Our evaluation in challenging outdoor conditions shows that our proposed map management process allows building and maintaining maps for precise visual localization over long time spans in a tractable and scalable fashion.
Expression of HIV regulatory and structural mRNA in the central nervous system.

OBJECTIVE HIV encephalitis is observed in approximately one-half of AIDS autopsies. Although most investigators would agree that central nervous system (CNS) macrophages are the predominant infected cell in HIV encephalitis, there remains some controversy regarding whether other CNS cells can be infected by HIV and thus show the molecular characteristics of such an infection. DESIGN AND METHODS Using reverse transcriptase polymerase chain reaction (PCR) and immunocytochemistry (ICC), we examined CNS tissues from AIDS and control autopsies for the presence of non-productive HIV infection. RESULTS Single-spliced mRNA for structural envelope proteins were detected in the basal ganglia of only one of nine HIV-seropositive autopsies without HIV encephalitis and none of five seronegative autopsy controls. Double-spliced mRNA for regulatory proteins (e.g., Nef and Tat) were not detected in either the seropositive non-HIV encephalitis or seronegative controls. Both single and double-spliced viral RNA could be detected in basal ganglia of 10 out of 13 autopsies with HIV encephalitis. Similar findings were obtained when cerebral white matter was examined. Using PCR primers that distinguish single from double-spliced mRNA, we found no evidence for selective expression of the Nef regulatory gene. CONCLUSIONS These data suggest that expression of HIV mRNA in the CNS is limited to those patients with HIV encephalitis. Further HIV encephalitis appears to be a chronic permissive infection of the CNS, without evidence of restricted Nef transcript expression.
Ceramide inhibits LPS‐induced production of IL‐5, IL‐10, and IL‐13 from mast cells

Mast cells are central regulators of allergic inflammation through production of various chemical mediators and cytokines. Bacterial infection occasionally worsens allergic inflammation. Although the exact mechanism of this phenomenon remains unclear, we have previously reported that LPS stimulates mast cells to produce not only pro‐inflammatory cytokines, such as IL‐6 and TNF‐α, but also Th2‐type cytokines, such as IL‐5 and IL‐13, and a regulatory cytokine, IL‐10. In the present study, we have studied the effect of ceramide on LPS‐mediated cytokine production from mast cells, as ceramide modulates various cellular functions in many cell types. Administration of cell‐permeable C8 ceramide reduced production of IL‐5, IL‐10, and IL‐13 from LPS‐stimulated mouse bone marrow‐derived mast cells (BMMCs) apparently through transcriptional inhibition, but did not affect IL‐6 or TNF‐α production. Consistently, LPS‐stimulated production of IL‐5, IL‐10, and IL‐13 from BMMCs is significantly enhanced in the presence of fumonisin B1, a de novo ceramide synthesis inhibitor. Interestingly, the same C8 ceramide treatment showed opposite effects on cytokine production from LPS‐stimulated macrophages, reducing IL‐6 and TNF‐α while not affecting IL‐10 production. C8 ceramide pretreatment significantly reduced LPS‐induced Akt phosphorylation in BMMCs, but not in macrophages. Furthermore, pretreatment of BMMCs by wortmannin, a specific inhibitor of PI3 kinase, inhibited LPS‐stimulated expression of IL‐5, IL‐10, and IL‐13, but not that of TNF‐α or IL‐6. Thus, ceramide appeared to down‐regulate LPS‐stimulated production of IL‐5, IL‐10, and IL‐13 from mast cells by inhibiting PI3 kinase‐Akt pathway in a cell type‐specific manner. J. Cell. Physiol. 213: 126–136, 2007. © 2007 Wiley‐Liss, Inc.
Human skin allografts as a useful adjunct in the treatment of purpura fulminans.

OBJECTIVE The aim of this report is to discuss the role of human skin allografts in surgical coverage procedures for patients with purpura fulminans. METHOD We describe cases of purpura fulminans in three adults and one infant treated at our burns unit between October 2006 and January 2008. RESULTS The application of cryopreserved human skin allografts allowed us to obtain immediate wound closure after necrosis excision and enabled our team to subsequently perform autografts on favourable graft recipient sites. CONCLUSION Recourse to human skin allografts must be considered a pertinent therapeutic option in patients with purpura fulminans.