Miracle-dz/UniFAR-FTUs huggingface dataset:
Setting the scene: Mobile and wearable technology for managing healthcare and wellbeing

The growing proliferation of mobile and wearable technology (MWT) offers interesting use cases when applied to health and wellness management. Current trends towards more longer term health and wellness management coupled with global challenges around the provision of healthcare to aging populations with tighter budget constraints, create rich opportunities to exploit this new technology to maintain health and wellness. This paper provides an overview of commonly available MWT and examines how it can be used in health and wellness systems. Case studies are given from two recent research projects and the issues and challenges that arise in the use of MWT are discussed. We conclude that MWT offers some key advantages in some healthcare situations, but that care must be taken to select appropriate technology for each use.
Monitoring indicators applied to Taiwan stock market

In the era of quantitative easing monetary policy and inflation, how to prevent monetary depreciation? It is necessary to know how to manage wealth to increase wealth. Wealth management as money saver as well as investing tool is a means to increase wealth by increasing sources and reducing consumption. It may be defined as the optimal efficacy and effectiveness of money via adequate and wise investment, but it is a big issue to find a simple handy way with effectiveness to gain profit among various investing manners. Thus, the scores of monitoring indicators (MIs) as the basis of investment in exchange traded funds (ETFs) via market trade were employed to verify the effectiveness of MIs to gain excess returns of ETFs. The subject was 312 times of MIs announced during 26 years from Jan 1984 to Dec 2009. In terms of findings, the scores of MIs rendered the profitable effectiveness by regular or single investment where total returns of the latter exceeded those of the former.
The workload of fishermen: a cross sectional survey among Danish commercial fishermen.

BACKGROUND Fishery has always been perceived as a physically demanding industry of a manual character. In recent years the physical work environment has developed positively and consequently the current situation in not fully described in the existing literature. This study aims to describe the work environment of Danish fishermen with regard to their physical workload and ergonomic factors. MATERIALS AND METHODS A cross sectional study was performed on a random sample of active Danish commercial fishermen (response rate: 28%) by means of a questionnaire on demographic and self-reported occupational and health data. Questions covering the physical workload were related to seven different work situations and a score summing up the workload was developed for the analysis of the relative impact on different groups of fishermen. RESULTS Almost all fishermen (96.2%) were familiar to proper lifting techniques but only 55.4% used them in their daily work. Standing work was the most applied work position (81.8%), while repetitive hand and finger movements and twisting and bending in the back were other frequent work situations. Deckhands had higher workload scores than skippers, while crew on Danish seiners had higher workload scores than fishermen in other vessel types. CONCLUSIONS Despite improved work environment in the Danish fishing industry, fishermen still experience high levels of workload and suboptimal ergonomic conditions, which are known to cause pain and impair musculoskeletal health. To address the specific areas of fishing with the highest workload, future investments in assistive devices to ease the demanding work and reduce the workload, should particularly address deckhands and less mechanized vessels.
Function of Apollo (SNM1B) at telomere highlighted by a splice variant identified in a patient with Hoyeraal–Hreidarsson syndrome

Telomeres, the protein–DNA complexes at the ends of linear chromosomes, are protected and regulated by the shelterin molecules, the telomerase complex, and other accessory factors, among which is Apollo, a DNA repair factor of the β-lactamase/β-CASP family. Impaired telomere protection in humans causes dyskeratosis congenita and Hoyeraal–Hreidarsson (HH) syndrome, characterized by premature aging, bone marrow failure, and immunodeficiency. We identified a unique Apollo splice variant (designated Apollo-Δ) in fibroblasts from a patient with HH syndrome. Apollo-Δ generates a dominant negative form of Apollo lacking the telomeric repeat-binding factor homology (TRFH)-binding motif (TBM) required for interaction with the shelterin TRF2 at telomeres. Apollo-Δ hampers the proper replication of telomeres, leading to major telomeric dysfunction and cellular senescence, but maintains its DNA interstrand cross-link repair function in the whole genome. These results identify Apollo as a crucial actor in telomere maintenance in vivo, independent of its function as a general DNA repair factor.
Characterization of aluminum nitride lamb wave resonators operating at 600°C for harsh environment RF applications

In this paper, aluminum nitride (AlN) Lamb wave resonators (LWR) operating in air from room temperature up to 600°C are demonstrated for the first time. To date, no AlN RF devices have been tested and characterized at extreme temperatures. This paper describes the design, fabrication and characterization of temperature compensated AlN Lamb wave resonators at 600°C. Temperature coefficients of frequency (TCF) of both uncompensated and compensated devices were measured. Quality factors against temperature were also recorded. This supports the use of piezoelectric AlN as the material platform for radio-frequency (RF) components and sensing applications in harsh environments.
Bovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus

Abstract Bovine lactoferrin (bLf) is a multifunctional glycoprotein that plays an important role in innate immunity against infections, including influenza. Here we have dissected bLf into its C- and N-lobes and show that inhibition of influenza virus hemagglutination and cell infection is entirely attributable to the C-lobe and that all major virus subtypes, including H1N1 and H3N2, are inhibited. By far-western blotting and sequencing studies, we demonstrate that bLf C-lobe strongly binds to the HA2 region of viral hemagglutinin, precisely the highly conserved region containing the fusion peptide. By molecular docking studies, three C-lobe fragments were identified which inhibited virus hemagglutination and infection at fentomolar concentration range. Besides contributing to explain the broad anti-influenza activity of bLf, our findings lay the foundations for exploiting bLf fragments as source of potential anti-influenza therapeutics.
Twenty years of Hendra virus: laboratory submission trends and risk factors for infection in horses

SUMMARY Hendra virus (HeV) was first described in 1994 in an outbreak of acute and highly lethal disease in horses and humans in Australia. Equine cases continue to be diagnosed periodically, yet the predisposing factors for infection remain unclear. We undertook an analysis of equine submissions tested for HeV by the Queensland government veterinary reference laboratory over a 20-year period to identify and investigate any patterns. We found a marked increase in testing from July 2008, primarily reflecting a broadening of the HeV clinical case definition. Peaks in submissions for testing, and visitations to the Government HeV website, were associated with reported equine incidents. Significantly differing between-year HeV detection rates in north and south Queensland suggest a fundamental difference in risk exposure between the two regions. The statistical association between HeV detection and stockhorse type may suggest that husbandry is a more important risk determinant than breed per se. The detection of HeV in horses with neither neurological nor respiratory signs poses a risk management challenge for attending veterinarians and laboratory staff, reinforcing animal health authority recommendations that appropriate risk management strategies be employed for all sick horses, and by anyone handling sick horses or associated biological samples.
Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics

Prioritizing the risk posed by thousands of chemicals potentially present in the environment requires exposure, toxicity, and toxicokinetic (TK) data, which are often unavailable. Relatively high throughput, in vitro TK (HTTK) assays and in vitro-to-in vivo extrapolation (IVIVE) methods have been developed to predict TK, but most of the in vivo TK data available to benchmark these methods are from pharmaceuticals. Here we report on new, in vivo rat TK experiments for 26 non-pharmaceutical chemicals with environmental relevance. Both intravenous and oral dosing were used to calculate bioavailability. These chemicals, and an additional 19 chemicals (including some pharmaceuticals) from previously published in vivo rat studies, were systematically analyzed to estimate in vivo TK parameters (e.g., volume of distribution [Vd], elimination rate). For each of the chemicals, rat-specific HTTK data were available and key TK predictions were examined: oral bioavailability, clearance, Vd, and uncertainty. For the non-pharmaceutical chemicals, predictions for bioavailability were not effective. While no pharmaceutical was absorbed at less than 10%, the fraction bioavailable for non-pharmaceutical chemicals was as low as 0.3%. Total clearance was generally more under-estimated for nonpharmaceuticals and Vd methods calibrated to pharmaceuticals may not be appropriate for other chemicals. However, the steady-state, peak, and time-integrated plasma concentrations of nonpharmaceuticals were predicted with reasonable accuracy. The plasma concentration predictions improved when experimental measurements of bioavailability were incorporated. In summary, HTTK and IVIVE methods are adequately robust to be applied to high throughput in vitro toxicity screening data of environmentally relevant chemicals for prioritizing based on human health risks.
Experimental Investigation of Solidification and Remelting over Cryocooled Sphere Using Different Concentrations of Brine Solution as Phase Change Material

Received: 7 January 2018 Accepted: 24 October 2018 In this investigation, the solidification, phase change, melting and heat transfer phenomenon from the outer surface of the solid sphere (stainless steel) having different dimensions were analyzed. Liquid nitrogen has been used to cool the sphere at a cryogenic temperature up to 192 °C, then dipped the sphere inside a phase change material (brine solution NaCl-H2O of different concentration at ambient temperature) and study the solidification and melting phenomenon. The thickness of ice formation at the outer surface of a sphere is measured for different concentration of brine solution. Variation of ice thickness is also measured for different concentration at different time intervals. It is interesting to note that the time duration of solidification of ice and melting is depending upon the concentration of the solution. Melting behavior of ice is discussed for different concentration.
Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells.

The mechanism(s) by which high-linear energy transfer a particles, like those emitted by inhaled radon and radon daughters, cause lung cancer has not been elucidated. Conceivably, DNA damage that is induced by a particles may be mediated by the metabolic generation of reactive oxygen species (ROS), in addition to direct a particle-DNA interactions and hydroxyl radical-DNA interactions. Using normal human lung fibroblasts, we investigated the hypothesis that densely ionizing alpha particles may induce the intracellular generation of superoxide (O2.-) and hydrogen peroxide (H2O2). Ethidium bromide and 2',7'-dichlorofluorescein, fluorescent products of the membrane-permeable dyes hydroethidine and 2',7'-dichlorofluorescin diacetate, respectively, were used to monitor the intracellular production of O2. - and H2O2, respectively, by flow cytometry. Compared to sham-irradiated cells, fibroblasts that were exposed to alpha particles (0.4-19 cGy) had significant increases in intracellular O2. - production, along with concomitant increases in H2O2 production. Further analyses suggest that the plasma membrane-bound NADPH-oxidase is primarily responsible for this increased intracellular generation of ROS and that the ROS response does not require direct nuclear or cellular "hits" by the a particles. In this latter regard, we additionally report that unirradiated cells also show the ROS response when they are incubated with serum-containing culture medium that has been exposed to a particles or when they are incubated with supernatants from a-irradiated cells. Our overall results support the possibility that a particles, at least in part, may mediate their DNA-damaging effects indirectly via a ROS-related mechanism.
Anatomic and etiological classification of congenital limb deficiencies

Limb deficiencies, the congenital absence or hypoplasia of a long bone and/or digits, vary greatly in their anatomy and etiology. Previous attempts to classify the range of possible phenotypes have not included all types of deficiencies. We present a new classification system, which includes all potential phenotypes. Infants with limb deficiencies were identified in the hospital‐based Active Malformations Surveillance Program at Brigham and Women's Hospital in Boston, MA from the years 1972 to 1974 and 1979 to 2000. Affected infants were classified based on the anatomy and apparent cause of their deficiencies. The prevalence rate of all types of limb deficiency was 0.79/1,000. Upper limb deficiencies were significantly more common than lower limb deficiencies. There was no significant difference in frequencies between deficiencies on the left and right sides of the body. Longitudinal defects were more common than terminal transverse defects; intercalary defects were uncommon. Longitudinal defects were most likely to occur on the preaxial side of the limb. Almost half of affected infants had affected digits, with normal long bones. The most common apparent cause of limb deficiencies was vascular disruption defects (0.22/1,000), such as amniotic band‐related limb deficiency. This new classification system includes deficiency of each long bone, as well as absence of any finger or toe. This system will make it possible to establish the prevalence of each specific phenotype. The large number of distinct apparent causes illustrates the marked etiologic heterogeneity of limb deficiencies. © 2011 Wiley‐Liss, Inc.
Role of Neutrophils in Response to Bordetella pertussis Infection in Mice

ABSTRACT Pertussis is an acute respiratory disease caused by the bacterium Bordetella pertussis, for which humans are the only known reservoir. During infection, B. pertussis releases several toxins, including pertussis toxin (PT) and adenylate cyclase toxin (ACT), which have both been shown to play roles in promoting bacterial growth during early infection in a mouse model. Furthermore, in vitro and in vivo studies suggest that PT and ACT affect neutrophil chemotaxis and/or function, thereby altering the innate immune response. In this study we depleted animals of neutrophils to investigate whether neutrophils play a protective role during B. pertussis infection in mice. In addition, by infection with toxin-deficient strains, we investigated whether neutrophils are the main targets for PT and/or ACT activity in promoting bacterial growth. Surprisingly, we found no role for neutrophils during B. pertussis infection in naïve mice. However, in previously infected (immune) mice or in mice receiving immune serum, we observed a significant role for neutrophils during infection. Furthermore, in this immune mouse model our evidence indicates that neutrophils appear to be the main target cells for ACT, but not for PT.
Spatial/Temporal Variations of Elemental Carbon, Organic Carbon, and Trace Elements in PM10 and the Impact of Land-Use Patterns on Community Air Pollution in Paterson, NJ

ABSTRACT An urban community PM10 (particulate matter ≤ 10 μm in aerodynamic diameter) air pollution study was conducted in Paterson, NJ, a mixed land-use community that is interspersed with industrial, commercial, mobile, and residential land-use types. This paper examines (1) the spatial/temporal variation of PM10, elemental carbon (EC), organic carbon (OC), and nine elements; and (2) the impact of land-use type on those variations. Air samples were collected from three community-oriented locations in Paterson that attempted to capture industrial, commercial, and mobile source-dominated emissions. Sampling was conducted for 24 hr every 6 days from November 2005 through December 2006. Samples were concurrently collected at the New Jersey Department of Environmental Protection-designated air toxics background site in Chester, NJ. PM10 mass, EC, OC, and nine elements (Ca, Cu, Fe, Pb, Mn, Ni, S, Ti, and Zn) that had more than 50% of samples above detection and known sources or are toxic were selected for spatial/temporal analysis in this study. The concentrations of PM10, EC, OC, and eight elements (except S) were significantly higher in Paterson than in Chester (P < 0.05). The concentrations of these elements measured in Paterson were also found to be higher during winter than the other three seasons (except S), and higher on weekdays than on weekends (except Pb). The concentrations of EC, Cu, Fe, and Zn at the commercial site in Paterson were significantly higher than the industrial and mobile sites; however, the other eight species were not significantly different within the city (P > 0.05). These results indicated that anthropogenic sources of air pollution were present in Paterson. The source apportionment confirmed the impact of vehicular and industrial emissions on the PM10 ambient air pollution in Paterson. The multiple linear regression analysis showed that categorical land-use type was a significant predictor for all air pollution levels, explaining up to 42% of the variability in concentration by land-use type only. IMPLICATIONS This study provides a useful approach to characterize community air pollution and identify the sources of concern and the impact of land-use type on community air pollution in an urban area with mixed emission sources. Data obtained from the air monitoring sites, which were located at community-oriented locations, can be used to better estimate community exposure to air pollution.
Role of Skill India Initiative in Indian Food Processing Industries

Indian food processing sector has shown promising growth with wider scope to accelerate agricultural economy of the country. It has given level playing to the multinational corporate to excel direct retailing of the food products. This study has tried to explore the factors affecting the quality delivery in the food processing industry. The conceptual framework has been developed on the basis of existing literature and finds nine responsible factors to deliver quality in the food processing industry. Statistical tests are used to examine the quest, based on the inputs from 50 food processing entrepreneurs. A survey based on structured questionnaire was conducted in three districts of Uttar Pradesh. The finding reveals that availability of educated and trained workers are the most challenging task for food processing players. The study further explores the potential and prospect of Skill India initiative in resolving the scarcity of qualified manpower. It is found that PMKVY (Pradhan Mantri Kaushal Vikas Yojana) is giving the meaningful result by adding expertise to employed and unemployed individuals. This initiative is producing competent workforce in almost every zone in India. It is needed to include industrial participation for delivering training so that the needs of both parties were fulfilled. JEL Classification: L66, J24, P23, L15, P47
Physiologic Properties of Myelin Proteins Revealed by their Expression in Nonglial Cells

The transfection paradigm described herein can be used to investigate the functional properties of individual nervous system proteins in ways that have not been explored before. In particular, observations on the "structural" proteins of myelin are being made that have already yielded certain unique insights into the physiologic properties of these polypeptides. The ease with which site-directed mutagenesis procedures can be applied to these systems should eventually enable us to define with great precision the "functional domains" within each myelin protein.
Design evaluation of a home-based telecare system for Chronic Heart Failure patients

In order to improve the care of Chronic Heart Failure (CHF) patients, a system has been developed for monitoring symptoms and document subjective judgments on health conditions in a home environment. Since system usability is an important issue, a two step evaluation of the solution was conducted. First a ten-patient survey was conducted, which was aimed at spotting possible problem areas. The second step involved a small trial in a home setting with CHF patients. The results are promising, indicating that the system is user friendly and easy to use, and that it is suitable as a prototype for the intended use.
Reasoning on Reasoning through Serious Games

This paper, based on a long term experience conducted in primary schools, investigates the cognitive abilities involved in playing with digital mind games. The experimental work with pupils was first focused on game dynamics and aimed to identify some general cognitive skills required to children to successfully interact with the games. Subsequently, a more detailed investigation was carried out focusing on the actual cognitive abilities required to solve specific reasoning tasks proposed in a variety of selected mind games. The different number of information to be taken into account and processed while tackling each reasoning task appeared to be the key element that differentiates pupils' performance. This finding was in-depth analyzed also in respect to the children's level of school achievement and some considerations were drawn confirming the potential of mind games for developing young students' reasoning abilities and also paving the way for better tuning related game-based interventions, from a methodological standpoint.
LA PERSONALIZACIÓN DEL PERIODISMO Y LAS REDES SOCIALES: DE COMUNICADORES A INFLUENCERS. ANÁLISIS DE LOS DIEZ PERIODISTAS ESPAÑOLES MÁS INFLUYENTES EN TWITTER

The role of the journalist has highly evolved due to social networks. These digital platforms have created a new way of doing and seeing journalism, a way based more on the professional opinions than on what is really being reported. In recent years the journalist has suffered a personalization in social networks because of several changes in the world of communication and has become in what is now called an influencer. All these changes have occurred thanks to the way that journalists act in social networks (especially Twitter) and the way in which it is accepted by users. These platforms are the main places in which journalists share their opinions on different topics (current or not) to their followers. It is the users and followers themselves who have caused the journalist change role making him become an influencer, and being more characterized by his personal way of dealing with the issues than by his work. For this reason, we are in a moment where users role is very important and decisive for communicators influencers. The main objective is to reach an active audience who knows how to respond and interact with the professional. One of the most important characteristics of influencers journalists is the number of followers in their personal accounts, but what really stands out from these professionals is their way of interacting with users on different topics. Universidad de Valladolid Raquel Puertas Miguel 2 Palabras clave Influencer; redes sociales; seguidores; periodista; opinión