Miracle-dz/UniFAR-FTUs huggingface dataset:
Social Determinants of Health and Implication for Adult Education in Ghana: A Conceptual Study

Article History: Received 11.06. 2019 Received in revised form 10.12. 2019 Accepted Tarih girmek için burayı tıklatın. Available online 01.01. 2020 The recognition that social factors have an important impact on people’s health has a long-standing history. However, there was a renewed interest when the Commission on Social Determinants of Health (SDOH) was established by World Health Organization (WHO) in 2005 to support countries and global health partners in addressing the social factors leading to ill health and health inequalities. Since then, the concept of SDOH and its applications have evolved and expanded as researchers have examined the dynamic socio-cultural and economic roots and routes to experiences of health and wellbeing in society. This paper explores how, where and to what benefit the social determinants of health concept has been applied to date, and how such applications have contributed to its critical evolution as a relevant and useful concept in health research, education and practice. This paper summarizes the key themes identified in the literature, broadly in keeping with the core material, social, cultural and economic dimensions of the concept with examples from Ghana, Africa. Through this process, this paper identifies strength and limitations of the concept and its implications for adult education, as well as knowledge gaps and future directions for work in this field, contributing to wider interdisciplinary discussions and debates around social determinants of adults’ health. The research model is crucial for adult educationalists when they design course curriculum for educational institutions.
Oligotrophication and its measures in the Seto Inland Sea, Japan

The Seto Inland Sea experienced eutrophication during the period of high economic growth and then subsequent oligotrophication due to reduction of inflow load. The nutrient concentration in the seawater peaked in the beginning of 1970’s, and thereafter, it has been decreasing. Dissolved inorganic nitrogen (DIN) has remarkably decreased in recent years following the decrease in dissolved inorganic phosphorus (DIP). As a result, Nori (Pyropia) production has decreased in recent years due to bleaching of leaves caused by DIN deficiency. Recent slack in fisheries production was also likely influenced by the nutrient depletion as evidenced by the fish catch using a compact trawl. The process of both eutrophication and oligotrophication that occurred in the Seto Inland Sea can be explained by hysteresis. We introduce several countermeasures to the oligotrophication in the Seto Inland Sea. In particular, to improve Nori production, local nutrient supply was experimentally augmented, such as by application of fertilizer, temporary discharge of dam water, sediment plowing, and ad hoc operations of relaxing sewage treatment water.
Knowledge Management System Analysis and Planning For Employee Recruitment and Training

The development of science in the era of globalization is happening so quickly. The ability of humans to develop a variety of science (knowledge) is getting better with the tacit and explicit knowledge. From this development both tacit and explicit knowledge can be combined and varied to a Knowledge Management System. PT SCF (Limited) Palembang branch is a company engaged in the field of inspection and certification services. The problem faced by this company is that the process and media for sharing and transferring knowledge between colleagues is still small and not yet entrenched. This condition makes the company less effective in terms of producing and disseminating knowledge to staff quickly and accurately. Documentation of daily activities and routines are not carried out in a planned and integrated manner. Each department carries out its own activities in its own way, for example storing documentation on a CD, as well as a piece of paper. So, the authors are interested in analyzing and designing Web Knowledge Management System. The methods used were the object analysis and design method. While the tools for modeling used was Unified Modeling Language (UML). The result obtained is a prototype web Knowledge Management System (KMS) that can be a media of information and knowledge sharing related to employee acceptance and training.
Intellectual fashion forecasting simulations and application

For over 40 years Boeing has published an annual forecast for the growth of air travel worldwide. Current Market Outlook has become a standard reference for planners in government and industry. Major methodological changes in the forecast occurred in mid of 1990. These were a result of rethinking the data, methods, and models. It turns out standard approaches over-emphasized the effect of GDP. On the other hand, statistics found a convincing and cogent link between trade and travel, even though the data appeared entirely random. Finally, a startlingly simple approach established the hitherto elusive link between travel and service quality. This talk is a light-hearted review of the things we did wrong and fixed, and the things we are still worried about. It provides a bittersweet contrast between the ways of industry and academia. In this study we discussed Identifying and tracking fashion trends, apply knowledge of fashion forecasting to understand how trends evolve and are interpreted by industry. As a bonus we introduce Occam’s Toothbrush an entirely new, hopelessly backwards, and entirely un-publishable way industry does hypothesis testing, but doesn’t realize it.
The specificities of plant enzymes and their effects on the seed oil quality The specificities of plant enzymes and their effects on the seed oil quality

Triglycerider, en glycerid med tre fettsyror, är den kemiska beståndsdelen i fröoljor. Fettsyrasammansättningen avgör oljors kemiska och fysikaliska egenskaper. Konventionella vegetabiliska oljor innehåller några få återkommande fettsyror, men växter kan producera flera hundratals olika fettsyror. Många växtoljor och deras fettsyror med specifika egenskaper är lämpliga som ersättning till många fossila oljebaserade råvaror. Växtförädlare och forskare modifierar därför fettsyrasammansättningen i oljeväxter för att förbättra deras industriella egenskaper. Erukasyra är en fettsyra, med omfattande användning inom industriella tillämpningar. Fettsyror härstammar från plastiderna i växter, men sammansättningen av triglycerider sker i endoplasmatisk retikulum, där membran-integrerade acyltransferaser katalyserar syntesen av olja. Modifieringar av fettsyror sker medan de är associerade med specifika lipidmolekyler. Olika typer av fettsyramodifikationer kräver associering med olika molekyler, och flera ovanliga fettsyror kräver flera sekventiella modifieringar. Det komplicerade systemet för syntes, modifiering och montering kräver därför kanalisering av fettsyror och substrat från olika subcellulära organ och samtidigt en överföring av fettsyror från olika lipidmolekyler, ofta vid flera tillfällen. Enzymerna som styr dessa processer har ofta mycket distinkta substratspecificiteter som vi undersökt här. Förändring av fröoljans fettsyrasammansättning eller introduktion av en exotisk fettsyra är en komplex process där man måste ta hänsyn till växternas endogena enzymer, deras substratspecificitet och de tillgängliga substratpoolerna. Detaljerade biokemiska karakteriseringar av viktiga enzymer är således avgörande för ett framgångsrikt resultat. Vi har grundligt undersökt ett antal acyltransferaser och andra enzymer involverade i lipidmetabolismen, huvudsakligen inriktad på erukasyra i flera växtarter, inklusive Arabidopsis, Camelina sativa, Brassica napus, Crambe hispanica ssp. abyssinica och Tropaeolum majus. DGAT2 katalyserar den acyl-CoA-beroende bildningen av triglycerider och är således ett av de viktiga acyltransferaserna involverade i syntesen av olja. Undersökningana indikerar att flera DGAT2 enzymers substratspecificitet utgör ett hinder för ytterligare ökning av erukasyrahalten i fröoljan. Vi har också undersökt aminosyrasekvensmotiv som styr specificiteten gentemot erukasyra i DGAT2. Nyckelord: Växtlipider, TAG, DGAT, acyltransferase, lipidsyntes, enzym specificitet, erukasyra, oljegröda Författarens adress: Simon Jeppson, SLU, Institutionen för växtförädling, Box 101, 230 53 Alnarp, Sverige Växtenzyms specificiteter och deras effekter på fröoljekvaliteten
Novel Polyhydroxylated Steroidal Saponins from Allium giganteum

From the bulbs of Allium giganteum, three new steroidal saponins, (25R)-3-O-acetyl-5α-spirostan-2α, 3β, 5α, 6β-tetraol 2-O-β-D-glucopyranoside (2), (25R)-5α-spirostan-2α, 3β, 5α, 6β-tetraol 2-O-β-D-glucopyranoside (3) and (25R)-3-O-benzoyl-5α-spirostan-2α, 3β, 5α, 6β-tetraol 2-O-β-D-glucopyranoside (4), have been isolated. The new saponins are unique in structure having the sugar moiety at the C-2 hydroxyl position on the steroidal skeleton.
Ortho-Biologic Treatment of Partial Thickness Rotator Cuff Tears with T2 Wetmap MRI Follow Up

Treatment of partial thickness tears of the rotator cuff is controversial in orthopedic surgery and the optimum treatment strategies continue to evolve. Recommendations vary widely across the spectrum from benign neglect with physical therapy, to surgical in-situ repair or takedown of the partial thickness tear to create a complete tear, followed by arthroscopic or open reconstruction. In 2006, we developed an experimental, autologous orthobiologic treatment for partial thickness tears of the rotator cuff with the goal of restoration of tissue biology and function using autologous bone marrow nucleated cell concentrate suspended in a fibrin matrix growth factor concentrate. The technique includes autologous bone marrow injectate modification within the legal limits of human tissue and cell product transplantation. The technique also includes low intensity pulsed ultrasound and tailored physical therapy depending on tear size, morphology and patient specific issues. This report details the treatment technique and posits mechanisms of treatment action responsible for the clinical success of treatment and includes a case presentation for discussion.
Physicochemical and Sensory Properties from Indonesian White Shrimp (Penaeus merguiensis) Jerky

Dendeng or jerky is the Indonesian traditional dried meat. It is commonly produced by using some spices and addition of starch at various levels. In this research, jerky was made by using fresh white shrimp flesh. White shrimp jerky is a versatile food product for consumption as a snack or meal. This research used three formulations with tapioca flour additions at 0% (A0, control), 5% (A1), 10% (A2), and 15% (A3) based on shrimp flesh weight. Shrimp does not have a wide surface like beef meat, so the processing of shrimp jerky involved only two steps, namely grinding and pressing. The protein, ash and water contents decreased with an increase in the percentage of tapioca flour. The sensory analysis of quantitative data revealed that no parameters were significantly different, except for textural properties. Overall, the addition of tapioca flour not exceeding 10% produced better physicochemical and sensory properties, similar to those of A0, the control. Shrimp jerky produced with or without flour could be a potential food product for consumption as a snack or meal.
Development of millet based instant weaning mix

The right nutrition during childhood has a profound impact on the future health, immunity and success of a child. Weaning is a period of transition for the infant during which its diet changes in terms of consistency and source. Weaning is a time of nutritional vulnerability. It represents a period of dietary transition, just when nutritional requirements for growth and brain development are high. Cereals in the composite mixes can be replaced with millets in the formulation to get the benefit of enhanced micronutrients. Millets have been found to possess high nutritive value compared to major cereals such as wheat and rice. In this study four formulations F1, F2 (B), F2(B+G) and F3 were formulated with different composition of Millets (Kodo, Foxtail, Finger and Little Millets). These formulations were analysed for its different physical, chemical and sensory attributes. The moisture content, carbohydrates, proteins, fat, crude fibre and ash percentages of prepared weaning mixes of different formulations were observed in the range of 4.82 to 6.71%, 56.77 to 68.92%, 14.3 to 23.17%, 4.28 to 11.06%, 2.5 to 6.0% and 2.8 to 7.6% respectively. Millet based weaning mixes were rich in Protein, ash and crude fiber compare to wheat based market sample. Calcium in formulated millet based products is nearer to the market sample without fortification. Among all these formulations, prepared weaning food based on F2(B+G) formulation had more acceptability in terms of nutritional and sensory aspect.
The Presence of Double-Stranded RNAs in Alternaria alternata Japanese Pear Pathotype and Their Participation in AK-toxin Productivity

The intracellular occurrence of viruses has been reported in major fungal taxa1). Most of the characterized mycoviruses contain segmented double-stranded RNA (dsRNA) genomes1). The presence of mycoviruses has been usually indicated by the occurrence of dsRNA and con firmed by the visualization of particles. In many cases, virus infection causes the morphological abnormalities and the unusual biological activities of fungi1). The dsRNA has been shown to also associate with different levels of virulence in several phytopathogenic fungi, e. g. hypovirulence in Endothia parasitica causing blight of chestnut1,2). Alternaria alternata Japanese pear pathotype, the causal organism of black spot disease of Japanese pear, produces AK-toxin as a host-specific toxin (HST)3). The HST is now known to be a critical determinant of pathogenesis of HST-producing fungi. Thus, the infectivity and host specificity of such pathogens are most likely governed by the ability to produce HST3). The AK-toxin productivity has been observed to be relatively unstable 4,5). The field isolates fre quently lose their ability to produce AK-toxin under laboratory and even field conditions4,5) Such toxin-less mutants simultaneously lose their pathogenicity to their host plants, e. g. Japanese pear cv. Nijisseiki, and become indistinguishable from saprophytic A. alternata. In the present investigation, we have studied on the relationship between the occurrence of dsRNA and AK-toxin productivity by using AK-toxin-producing isolates and AK-toxin-less mutants. The isolates of A. alternata examined in this study are listed in Table 1. The AK-toxin-less mutants are those which had expressed pathogenicity to the host plant just after isolation from naturally occurred lesions, but lost pathogenicity along with the loss of AK-toxin productivity during culture in laboratory. The dsRNA was extracted from 10 g of frozen mycelia grown in a potato dextrose broth
Multivariate best linear unbiased predictor as a tool to improve multi-trait selection in sugarcane

The objective of this work was to evaluate the use of the multivariate best linear unbiased predictor (BLUP) method for multi-trait selection, to estimate the genetic parameters in sugarcane (Saccharum officinarum) genotypes. The experiment was carried out in a randomized complete block design with 21 sugarcane genotypes, in seven crop years, in a factorial arrangement with three replicates. The measured traits were: total yield of stems per hectare, total volume of juice per hectare, production of total soluble sugars, and stem length. The source variation in the crop years strongly contributed for the obtention of the expected values of the sum of squares, without causing distortions in the variance components and genetic variables. The measured traits showed genetic variability and allowed of efficient univariate and multivariate selections. The highest selection efficiency was obtained by using more than eight measurements, since they favored the estimates of heritability, accuracy, and repeatability. The 'IAC873396', 'Nova Iraí', 'IACSP 93-6006', and 'RB 835089' genotypes were superior as to the traits tested, regardless of the crop year. The BLUP multivariate technique for multi-trait selection is robust and allows of the increasing of the selection gains, accuracy, and reliability of predictions for sugarcane breeding.
Influence of Rye Pentosans on the Growth of Chicks

Abstract Two experiments were conducted with 6-day-old chicks to determine if growth and feed conversion efficiencies were depressed when isolated water-soluble and water-insoluble pentosans from Puma rye were added to wheat-based diets at a level approximately the same as those found in similarly formulated rye-based diets. Quantitation of pentosans by the aniline acetate method using xylose as a standard showed that Puma rye contained (DM basis) 1.9% water-soluble and 6.5% water-insoluble pentosans. The results of the first feeding trial demonstrated that both the water extract and the water-soluble pentosan fractions added to a wheat-based diet caused a significant but similar depression in weight gain and feed conversion efficiency. In the second feeding trial there was a depression in feed intake (5 to 17%), growth (19 to 29%), and feed conversion efficiency (14 to 17%) when an equivalent of 1.04 to 1.4% water-soluble pentosans was added to a wheat containing basal diet. When wheat diets contained 3.4% added water-insoluble pentosans the corresponding depressions were 34, 50, and 33%, respectively, compared to the control wheat diet. It may be concluded that both soluble and insoluble pentosans depress growth but that the insoluble pentosans are the major antigrowth factor because of their higher concentration in rye grain. The antigrowth activity of both pentosans fractions could be attributed to their extremely viscous and sticky properties, to their ability to retain large volumes of water, and to interference with nutrient utilization. These properties may also affect feed intake.
Semi-supervised Network for Detection of COVID-19 in Chest CT Scans

Deep Learning-based chest Computed Tomography (CT) analysis has been proven to be effective and efﬁcient for COVID-19 diagnosis. Existing deep learning approaches heavily rely on large labeled data sets, which are difﬁcult to acquire in this pandemic situation. Therefore, semi-supervised approaches are in demand. In this paper, we propose an end-to-end semi-supervised COVID-19 detection approach, ResNext+, that only requires volume level data labels and can provide slice level prediction. The proposed approach incorporates a lung segmentation mask as well as spatial and channel attention to extract spatial features. Besides, Long Short Term Memory (LSTM) is utilized to acquire the axial dependency of the slices. Moreover, a slice attention module is applied before the ﬁnal fully connected layer to generate the slice level prediction without additional supervision. An ablation study is conducted to show the efﬁciency of the attention blocks and the segmentation mask block. Experimental results, obtained from publicly available datasets, show a precision of 81.9% and F1 score of 81.4%. The closest state-of-the-art gives 76.7% precision and 78.8% F1 score. The 5% improvement in precision and 3% in the F1 score demonstrate the effectiveness of the proposed method. It is worth noticing that, applying image enhancement approaches do not boost the performance of the proposed method, sometimes even harm the scores, although the enhanced images illustrate better perceived visual image quality
IMGN779, a CD33-Targeted Antibody-Drug Conjugate (ADC) with a Novel DNA-Alkylating Effector Molecule, Induces DNA Damage, Cell Cycle Arrest, and Apoptosis in AML Cells.

IMGN779 is a CD33-targeting ADC consisting of a humanized anti-CD33 antibody, Z4681A, conjugated to DGN462, a novel DNA-alkylating agent, through a cleavable disulfide linker, sulfo-SPDB. CD33 is broadly expressed on leukemic blasts of patients with AML, making it a promising target for AML therapy. DGN462 is a member of the novel IGN class of DNA-acting cytotoxic agents, that consists of an indolino-benzodiazepine dimer containing a mono-imine moiety. Potent killing of AML tumor cells by DGN462 and IMGN779 has previously been demonstrated in vitro (K. Whiteman et. al, ASH 2014 #2321). Here we describe studies elucidating the mechanism of action of this novel payload in the AML cell lines: MV4-11, HL60, and EOL-1. The ability of DGN462 to alkylate DNA was demonstrated in an AML cell line by isolation and analysis of the genomic DNA from cells. DGN462 was found to co-purify with DNA, demonstrating that it covalently reacts with cellular DNA. A comet assay was performed confirming that DGN462 does not cross-link DNA. H2AX is known to be phosphorylated on serine 139 in response to DNA damage. Using flow cytometry, we assessed the phosphorylation of H2AX in AML cell lines following exposure to DGN462 and IMGN779. Increases in phosphorylated H2AX levels were detected as early as 4 hours following exposure to DGN462-SMe and 12 hours following exposure to IMGN779. Additional flow cytometry analysis showed that exposure to DGN462-SMe and IMGN779 leads to S-phase accumulation, G2/M arrest, followed by induction of apoptotic markers (cleaved PARP and cleaved Caspase-3) at later time points. Ex vivo studies using AML patient samples also showed elevation of phosphorylated H2AX and an increase in apoptosis in myeloid blasts following exposure to DGN462-SMe and IMGN779. As a demonstration of proof-of-mechanism in AML disease models, our results suggest that cell killing by IMGN779 is mediated by DNA damage, as a consequence of DNA alkylation. The DNA damage response is accompanied by cell cycle arrest, which leads to apoptosis. This relationship will be further explored in additional AML preclinical models to support the use of phosphorylated H2AX as a pharmacodynamic biomarker for IMGN779 activity in future clinical studies. Disclosures Krystal: ImmunoGen, Inc.: Employment, Equity Ownership. Walker: ImmunoGen, Inc.: Employment, Equity Ownership. Fishkin: ImmunoGen, Inc.: Employment, Equity Ownership. Audette: ImmunoGen, Inc.: Employment, Equity Ownership. Kovtun: ImmunoGen, Inc.: Employment, Equity Ownership. Romanelli: ImmunoGen, Inc.: Employment, Equity Ownership.
Cognitive motivation of English and Russian expressions containing the words eye(s) and glaz(a): a corpus-based approach

This master’s thesis studies the motivation of English and Russian figurative expressions with the components eye(s) and глаз(а) that is based on cultural models. The main aim of the thesis is to examine the semantic characteristics of figurative expressions and their relation to cognitive mechanisms (such as conceptual metaphor, conceptual metonymy, and conventional knowledge) motivating them. The study relies on the cognitive linguistic claim that our mind is inherently embodied and that meaning arises from our more general knowledge of the world embodied in our conceptual system. The analysis of figurative expressions with the component eye(s)/глаз(а) tries to show how embodiment affects and shapes people's understanding of the meaning of linguistic expressions, while a comparative study of languages helps us see how universal bodily experience is reflected in languages which share a similar cultural background.