Miracle-dz/UniFAR-FTUs huggingface dataset:
Distributed Compressed Sensing Based Ground Moving Target Indication for Dual-Channel SAR System

The dual-channel synthetic aperture radar (SAR) system is widely applied in the field of ground moving-target indication (GMTI). With the increase of the imaging resolution, the resulting substantial raw data samples increase the transmission and storage burden. We tackle the problem by adopting the joint sparsity model 1 (JSM-1) in distributed compressed sensing (DCS) to exploit the correlation between the two channels of the dual-channel SAR system. We propose a novel algorithm, namely the hierarchical variational Bayesian based distributed compressed sensing (HVB-DCS) algorithm for the JSM-1 model, which decouples the common component from the innovation components by applying variational Bayesian approximation. Using the proposed HVB-DCS algorithm in the dual-channel SAR based GMTI (SAR-GMTI) system, we can jointly reconstruct the dual-channel signals, and simultaneously detect the moving targets and stationary clutter, which enables sampling at a further lower rate in azimuth as well as improves the reconstruction accuracy. The simulation and experimental results show that the proposed HVB-DCS algorithm is capable of detecting multiple moving targets while suppressing the clutter at a much lower data rate in azimuth compared with the compressed sensing (CS) and range-Doppler (RD) algorithms.
Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure

Malaria immunity is complex and multi-faceted, and fundamental gaps remain in our understanding of how it develops. Here, we use detailed clinical and entomological data from three parallel cohort studies conducted across the malaria transmission spectrum in Uganda to quantify the development of immunity against symptomatic Plasmodium falciparum as a function of age and transmission intensity. We focus on: anti-parasite immunity (i.e; ability to control parasite densities) and anti-disease immunity (i.e; ability to tolerate higher parasite densities without fever). Our findings suggest a strong effect of age on both types of immunity, that remains significant after adjusting for cumulative exposure. They also show a non-linear effect of transmission intensity, where children experiencing the lowest transmission appear to develop immunity faster than those experiencing higher transmission. These findings illustrate how anti-parasite and anti-disease immunity develop in parallel, reducing the probability of experiencing symptomatic malaria upon each subsequent P. falciparum infection.
Expert consensus statement on the science of HIV in the context of criminal law

Globally, prosecutions for non‐disclosure, exposure or transmission of HIV frequently relate to sexual activity, biting, or spitting. This includes instances in which no harm was intended, HIV transmission did not occur, and HIV transmission was extremely unlikely or not possible. This suggests prosecutions are not always guided by the best available scientific and medical evidence.
Genome sequence and genetic transformation of a widely distributed and cultivated poplar

Summary Populus alba is widely distributed and cultivated in Europe and Asia. This species has been used for diverse studies. In this study, we assembled a de novo genome sequence of P. alba var. pyramidalis (= P. bolleana) and confirmed its high transformation efficiency and short transformation time by experiments. Through a process of hybrid genome assembly, a total of 464 M of the genome was assembled. Annotation analyses predicted 37 901 protein‐coding genes. This genome is highly collinear to that of P. trichocarpa, with most genes having orthologs in the two species. We found a marked expansion of gene families related to histone and the hormone auxin but loss of disease resistance genes in P. alba if compared with the closely related P. trichocarpa. The genome sequence presented here represents a valuable resource for further molecular functional analyses of this species as a new tree model, poplar breeding practices and comparative genomic analyses across different poplars.
Fast and Robust Image Upsampling by Local Adaptive Gradient Field Sharpening Transform

This paper proposes an image upsampling scheme by introducing a new gradient field sharpening transform that converts the blurry gradient field of upsampled low-resolution (LR) image to a much sharper gradient field of original high-resolution (HR) image. Different from the existing methods that need to figure out the whole gradient profile structure and locate the edge points, we derive a new approach that sharpens the gradient field adaptively only based on the pixels in a small neighborhood. To maintain image contrast, image gradient is adaptively scaled to keep the integral of gradient field stable. Finally the HR image is reconstructed by fusing the LR image with the sharpened HR gradient field. Experimental results demonstrate that the proposed algorithm can generate more accurate gradient field and produce super-resolved images with better objective and visual qualities. Another advantage is that the proposed gradient sharpening transform is very fast and suitable for low-complexity applications.
Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress

Listeria monocytogenes, a Gram-positive facultative anaerobic bacterium, is becoming a popular vector for cancer immunotherapy. Indeed, multiple vaccines have been developed utilizing modified Listeria as a tool for generating immune responses against a variety of cancers. Moreover, over a dozen clinical trials testing Listeria cancer vaccines are currently underway, which will help to understand the utility of Listeria vaccines in cancer immunotherapy. This review aims to summarize current views on how Listeria-based vaccines induce potent antitumor immunity and the current state of Listeria-based cancer vaccines in clinical trials.
Novel Sales Tracking Method to Evaluate a Healthy Corner Store Intervention

This article describes a Supplemental Nutrition Assistance Program—Education-funded (SNAP-Ed) healthy corner store intervention and novel evaluation method for tracking sales of promoted foods in two corner stores in North Carolina. The healthy corner store intervention was designed to encourage the purchase of healthy foods among SNAP participants. Stickers were placed on eligible foods to highlight healthy options as well as assist with tracking the sales of those products. Store staff removed the sticker and placed it on a tracking sheet that recorded the date, number of healthy foods purchased, whether the purchased item(s) contained a fruit or vegetable, and the type of payment. Storeowners were interested in participating and remained engaged throughout the program; however, there were challenges with fidelity to the intervention and its evaluation using the sticker method to track sales. Additional research on methods for evaluating healthy retail interventions that are simple, low cost, and feasible for retailers that do not have electronic sales data is needed.
FGFR3 mutation increases bladder tumourigenesis by suppressing acute inflammation

Recent studies of muscle‐invasive bladder cancer show that FGFR3 mutations are generally found in a luminal papillary tumour subtype that is characterised by better survival than other molecular subtypes. To better understand the role of FGFR3 in invasive bladder cancer, we examined the process of tumour development induced by the tobacco carcinogen OH‐BBN in genetically engineered models that express mutationally activated FGFR3 S249C or FGFR3 K644E in the urothelium. Both occurrence and progression of OH‐BBN‐driven tumours were increased in the presence of an S249C mutation compared to wild‐type control mice. Interestingly, at an early tumour initiation stage, the acute inflammatory response in OH‐BBN‐treated bladders was suppressed in the presence of an S249C mutation. However, at later stages of tumour progression, increased inflammation was observed in S249C tumours, long after the carcinogen administration had ceased. Early‐phase neutrophil depletion using an anti‐Ly6G monoclonal antibody resulted in an increased neutrophil‐to‐lymphocyte ratio at later stages of pathogenesis, indicative of enhanced tumour pathogenesis, which supports the hypothesis that suppression of acute inflammation could play a causative role. Statistical analyses of correlation showed that while initial bladder phenotypes in morphology and inflammation were FGFR3‐dependent, increased levels of inflammation were associated with tumour progression at the later stage. This study provides a novel insight into the tumour‐promoting effect of FGFR3 mutations via regulation of inflammation at the pre‐tumour stage in the bladder. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Eating Out-of-Home in Adult Residents in Shanghai and the Nutritional Differences among Dining Places

Background: With the rapid development of Shanghai’s economy, diet habits have undergone great changes. The study aimed to examine the situation of out-of-home (OH) eating in Shanghai adults and the nutrition characteristics of eating in different dining places, and to assess the social demographic determinants of eating OH. Method: Data was sourced from the Shanghai Diet and Health Survey (SDHS) involving people aged 18 years or older in 2012–2013. The food frequency questionnaire (FFQ) and three-day 24-h dietary recall (24-HDR) were used to collect dietary intake data on how people eat out in a cross-sectional study of 1689 adults. OH food refers to the food prepared or consumed away from home. We define that people who eat at least one meal prepared away from home in each survey have a habit of eating outside. The multiple linear and logistic regression methods were used for statistical analysis. Results: The prevalence of eating OH and at restaurants was only 55.1% and 31.8%, respectively. There was an increase in energy, protein, carbohydrate, fat, and iron intake while eating OH. Restaurant and company/school canteen consumption were both associated with an increase in daily total energy intake of 140 kcal and 91 kcal, and fat intake of 6.0 g and 4.3 g, respectively. However, eating at restaurants was associated with higher intake of 548 mg of sodium. However, no significant association was observed between eating at canteens and higher sodium intake. Conclusions: Eating OH related to a poor diet quality, and the diet quality was different between restaurant and canteen food. There may be a need for interventions to target residents’ overall dining-out behavior, particularly focusing on the consumption of restaurant food.
Validity and reliability of assessing diaphragmatic mobility by area on X-rays of healthy subjects

ABSTRACT Objective: To investigate the concurrent validity, as well as the intra- and inter-rater reliability, of assessing diaphragmatic mobility by area (DMarea) on chest X-rays of healthy adults. Methods: We evaluated anthropometric parameters, pulmonary function, and diaphragmatic mobility in 43 participants. Two observers (rater A and rater B) determined diaphragmatic mobility at two time points. We used Pearson’s correlation coefficient to evaluate the correlation between DMarea and the assessment of diaphragmatic mobility by distance (DMdist). To evaluate intra- and inter-rater reliability, we used the intraclass correlation coefficient (ICC [2,1]), 95% CI, and Bland-Altman analysis. Results: A significant correlation was found between the DMarea and DMdist methods (r = 0.743; p < 0.0001). For DMarea, the intra-rater reliability was found to be quite high for the right hemidiaphragm (RHD)-ICC (2,1) = 0.92 (95% CI: 0.86-0.95) for rater A and ICC (2,1) = 0.90 (95% CI: 0.84-0.94) for rater B-and the left hemidiaphragm (LHD)-ICC (2,1) = 0.96 (95% CI: 0.93-0.97) for rater A and ICC (2,1) = 0.91 (95% CI: 0.81-0.95) for rater B-(p < 0.0001 for all). Also for DMarea, the inter-rater reliability was found to be quite high for the first and second evaluations of the RHD-ICC (2,1) = 0.99 (95% CI: 0.98-0.99) and ICC (2,1) = 0.95 (95% CI: 0.86-0.97), respectively-and the LHD-ICC (2,1) = 0.99 (95% CI: 0.98-0.99) and ICC (2,1) = 0.94 (95% CI: 0.87-0.97)-(p < 0.0001 for both). The Bland-Altman analysis showed good agreement between the mobility of the RHD and that of the LHD. Conclusions: The DMarea method proved to be a valid, reliable measure of diaphragmatic mobility.
Association between LRH-1 single nucleotide polymorphisms and unexplained recurrent spontaneous abortion in Chinese Han couples

Abstract To explore the genetic relationships between LRH-1 (rs2816948), CYP19 (rs727479 and rs700518), and P450scc (rs4077582) as a potential mechanism behind unexplained recurrent spontaneous abortions in a Chinese Han population. A case-control study was used and featured two groups: Patients with unexplained recurrent miscarriage (n = 82, abortion group) and those who voluntary surrendered of a normal early pregnancy (n = 97, control group). Abortion villi samples were obtained from all patients. Genomic DNA was later extracted and sequenced, after which statistical analyses performed to assess the relationship between single nucleotide polymorphisms and unexplained recurrent spontaneous abortions. There were significant differences in the genotypic and allelic distribution (p < .05) for CYP19 (rs727479) between the abortion and the control groups. There were no significant differences in the genotypic or allelic distributions (p > .05) for either the LRH-1 (rs2816948) or CYP19 (rs700518). There were also significant genotypic differences (p < .05) for P450scc (rs4077582), but no significant differences for its allelic distribution (p > .05). There was a significant correlation between the occurrence of unexplained recurrent spontaneous abortion and CYP19 (rs727479) single nucleotide polymorphisms. 摘要 本研究将探讨LRH-1（rs2816948）, CYP19（rs727479和rs700518）和P450scc（rs4077582）作为中国汉族人群原因不明的复发性自然流产的潜在机制之间的遗传关系。 采用病例对照研究, 分为两组：原因不明的复发性流产患者（n = 82, 流产组）和自愿放弃正常早孕的患者（n = 97, 对照组）。 从所有患者获得流产绒毛样品, 随后提取基因组DNA并测序, 之后进行统计分析以评估单核苷酸多态性与不明原因的复发性自然流产之间的关系。 在流产和对照组之间, CYP19（rs727479）的基因型和等位基因分布（p <. 05）存在显著差异。 对于LRH-1（rs2816948）或CYP19（rs700518）, 基因型或等位基因分布（p> . 05）没有显著差异。 P450scc（rs4077582）也存在显著的基因型差异（p <. 05）, 但其等位基因分布没有显著差异（p> . 05）。 不明原因复发性自然流产的发生与CYP19（rs727479）单核苷酸多态性之间存在显著相关性。
Pruritus in hemodialysis patients: association with phosphorus intake and serum calcium level.

OBJECTIVE To analyze the association between the occurrence of pruritus and adherence to the prescribed diet, biochemical indicators of renal function and the quality of hemodialysis in chronic renal patients. METHOD A cross-sectional study performed at a dialysis clinic in the Northeast of Brazil, with 200 patients undergoing hemodialysis in the first half of 2015.To analyze the data, inferential statistics were used, using Chi-Square and Fisher's Exact tests; and Mann Whitney U test. RESULTS The pruritus was present in 51% of the sample, being associated statistically with phosphorus consumption (P = 0.024) and elevation of serum calcium (P = 0.009). CONCLUSION Pruritus in chronic renal patients undergoing hemodialysis is influenced by adequate nonadherence to the prescribed diet, in addition to the elevation of biochemical indicators of renal function.
Neuromodulation of reinforced skill learning reveals the causal function of prefrontal cortex

Accumulating evidence has suggested functional interactions between prefrontal cortex (PFC) and dissociable large‐scale networks. However, how these networks interact in the human brain to enable complex behaviors is not well‐understood. Here, using a combination of behavioral, brain stimulation and neuroimaging paradigms, we tested the hypothesis that human PFC is required for successful reinforced skill formation. We additionally tested the extent to which PFC‐dependent skill formation is related to intrinsic functional communication with this region. We report that inhibitory noninvasive transcranial magnetic stimulation over lateral PFC, a hub region with a diverse connectivity profile, causally modulated effective reinforcement‐based motor skill acquisition. Furthermore, PFC‐dependent skill formation was strongly related to the strength of functional connectivity between the PFC and regions in the sensorimotor network. These results point to the involvement of lateral PFC in the neural architecture that underlies the acquisition of complex skills, and suggest that, in relation to skill acquisition, this region may be involved in functional interactions with sensorimotor networks.
Level-Specific Differences in Systemic Expression of Pro- and Anti-Inflammatory Cytokines and Chemokines after Spinal Cord Injury

While over half of all spinal cord injuries (SCIs) occur in the cervical region, the majority of preclinical studies have focused on models of thoracic injury. However, these two levels are anatomically distinct—with the cervical region possessing a greater vascular supply, grey-white matter ratio and sympathetic outflow relative to the thoracic region. As such, there exists a significant knowledge gap in the secondary pathology at these levels following SCI. In this study, we characterized the systemic plasma markers of inflammation over time (1, 3, 7, 14, 56 days post-SCI) after moderate-severe, clip-compression cervical and thoracic SCI in a rat model. Using high-throughput ELISA panels, we observed a clear level-specific difference in plasma levels of VEGF, leptin, IP10, IL18, GCSF, and fractalkine. Overall, cervical SCI had reduced expression of both pro- and anti-inflammatory proteins relative to thoracic SCI, likely due to sympathetic dysregulation associated with higher level SCIs. However, contrary to the literature, we did not observe level-dependent splenic atrophy with our incomplete SCI model. This is the first study to compare the systemic plasma-level changes following cervical and thoracic SCI using level-matched and time-matched controls. The results of this study provide the first evidence in support of level-targeted intervention and also challenge the phenomenon of high SCI-induced splenic atrophy in incomplete SCI models.
Effect of a lateral infraclavicular brachial plexus block on the axillary and suprascapular nerves as determined by electromyography – a cohort study

We aimed to examine to what extent a lateral infraclavicular brachial plexus block affected the axillary and the suprascapular nerve. We included patients undergoing hand surgery anaesthetised with a lateral infraclavicular brachial plexus block. Our primary outcome was the relative change in surface electromyography during maximum voluntary isometric contraction of the medial deltoid muscle (axillary nerve) and the infraspinatus muscle (suprascapular nerve) from baseline to 30 min after the block procedure. A reduction in electromyography of > 50% defined a successful block. The impact of the block on the shoulder nerves was compared with the surgical target nerves of the arm and hand (musculocutaneous, radial, median and ulnar nerves). Twenty patients were included. The medians of the relative changes in the surface electromyography were significantly reduced (both p < 0.001) with 92% for the deltoid muscle and 30% for the infraspinatus muscle, respectively. In total, 18 out of 20 patients had reductions > 50% for the deltoid muscle, which was significantly different from the infraspinatus muscle, where the proportion was 5 out of 20 (p < 0.001). The medians of the relative reductions in electromyography for the arm and hand muscles were 90–96%, similar to the effect on the deltoid muscle. Our results suggest that a lateral infraclavicular block provides block of the axillary nerve comparable to the block of the surgical target nerves. The suprascapular nerve is blocked to a lesser degree. Combining a lateral infraclavicular brachial plexus block with a selective suprascapular block for shoulder surgery warrants further studies.
Finite-Time Passivity and Synchronization of Coupled Reaction–Diffusion Neural Networks With Multiple Weights

In this paper, two multiple weighted coupled reaction–diffusion neural networks (CRDNNs) with and without coupling delays are introduced. On the one hand, some finite-time passivity (FTP) concepts are proposed for the spatially and temporally system with different dimensions of output and input. By choosing appropriate Lyapunov functionals and controllers, several sufficient conditions are presented to ensure the FTP of these CRDNNs. On the other hand, the finite-time synchronization (FTS) problem is also discussed for the multiple weighted CRDNNs with and without coupling delays, respectively. Finally, two numeral examples with simulation results are provided to verify the effectiveness of the obtained FTP and FTS criteria.
PSE - PROTAGONIZANDO A PREVENÇÃO DE LESÕES ESPORTIVAS NO FUTEBOL DE 5

O Futebol de 5 é uma modalidade paralímpica exclusiva para cegos ou deficientes visuais. Por serem atletas do alto rendimento torna-se importante monitorar a carga de treino, sendo uma das formas a determinação da PSE (Percepção Subjetiva de Esforço). O objetivo do estudo foi examinar se a distribuição da carga de treino foi adequada para prevenir lesões esportivas de sobrecarga na Seleção Brasileira de Futebol de 5. Como objetivos específicos buscou-se investigar os parâmetros adotados para quantificar as cargas e quais os eventos críticos que predispõem ao desenvolvimento de lesões de sobrecarga neste esporte.
Venomics: A Mini-Review

Venomics is the integration of proteomic, genomic and transcriptomic approaches to study venoms. Advances in these approaches have enabled increasingly more comprehensive analyses of venoms to be carried out, overcoming to some extent the limitations imposed by the complexity of the venoms and the small quantities that are often available. Advances in bioinformatics and high-throughput functional assay screening approaches have also had a significant impact on venomics. A combination of all these techniques is critical for enhancing our knowledge on the complexity of venoms and their potential therapeutic and agricultural applications. Here we highlight recent advances in these fields and their impact on venom analyses.
Self-Persuasion Through Mobile Applications: Exploring Different Routes to Health Behavioral Change

Countless messages and campaigns have been designed to convince individuals to engage in healthy behaviors in their daily lives. Because the vast majority of these messages are typically generated by others, the current study explores the effects of self-generated messages in the context of mobile media. A 3 × 2 (persuasion: self- vs. other-generated narrative vs. other-generated non-narrative × topic: regular exercise vs. healthy diet) field experiment (n = 133) was conducted during a 10-day timeframe. Results indicate that self-generated messages were more successful than other-generated messages at increasing vegetable consumption and fruit intake by way of boosting pro-attitudinal arguments and health self-efficacy. However, both self- and other-generated messages failed to increase regular exercise during the study period. We discuss theoretical and practical implications for health interventions.