Miracle-dz/UniFAR-FTUs huggingface dataset:
Designing a B2B digital communication marketing strategy in a consultancy context

Digitization has become part of our daily routines changing therefore the customer behaviour. The variety of digital channels including social networks leads to a business revolution. Nowadays, the SME’s are compelled to adapt to the new online environment in order to survive. Thus, firms’ are faced with the challenge of developing good marketing strategies by adopting the right digital communication channels that fulfil its objectives. From this perspective, this research aims to design a digital communication marketing strategy in B2B consultancy context using a real case study. A quantitative research using survey method is adopted to carry on this project. Research findings suggest that e-mail is the preferred digital communication channel by B2B clients in consultancy context. Thus, a newsletter campaign integrated with Facebook was designed to increase brand awareness, spread positive word-of-mouth communications, get better insight into clients and attract new ones. This study advances the knowledge of digital marketing in consultancy context as well as Portuguese B2B and service communication literature, by finding that social media is not a crucial communication channel for Portuguese consultancy SME’s (Small Medium Entrprises). In contrast, this study suggests that they have to focus more on developing innovative strategies appropriate to the preferred e-mail channel.
Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized phase III trial.

PURPOSE In platinum-resistant ovarian cancer (OC), single-agent chemotherapy is standard. Bevacizumab is active alone and in combination. AURELIA is the first randomized phase III trial to our knowledge combining bevacizumab with chemotherapy in platinum-resistant OC. PATIENTS AND METHODS Eligible patients had measurable/assessable OC that had progressed < 6 months after completing platinum-based therapy. Patients with refractory disease, history of bowel obstruction, or > two prior anticancer regimens were ineligible. After investigators selected chemotherapy (pegylated liposomal doxorubicin, weekly paclitaxel, or topotecan), patients were randomly assigned to single-agent chemotherapy alone or with bevacizumab (10 mg/kg every 2 weeks or 15 mg/kg every 3 weeks) until progression, unacceptable toxicity, or consent withdrawal. Crossover to single-agent bevacizumab was permitted after progression with chemotherapy alone. The primary end point was progression-free survival (PFS) by RECIST. Secondary end points included objective response rate (ORR), overall survival (OS), safety, and patient-reported outcomes. RESULTS The PFS hazard ratio (HR) after PFS events in 301 of 361 patients was 0.48 (95% CI, 0.38 to 0.60; unstratified log-rank P < .001). Median PFS was 3.4 months with chemotherapy alone versus 6.7 months with bevacizumab-containing therapy. RECIST ORR was 11.8% versus 27.3%, respectively (P = .001). The OS HR was 0.85 (95% CI, 0.66 to 1.08; P < .174; median OS, 13.3 v 16.6 months, respectively). Grade ≥ 2 hypertension and proteinuria were more common with bevacizumab. GI perforation occurred in 2.2% of bevacizumab-treated patients. CONCLUSION Adding bevacizumab to chemotherapy statistically significantly improved PFS and ORR; the OS trend was not significant. No new safety signals were observed.
CK2 activity is required for the interaction of FGF14 with voltage‐gated sodium channels and neuronal excitability

Recent data shows that fibroblast growth factor 14 (FGF14) binds to and controls the function of the voltage‐gated sodium (Nav) channel with phenotypic outcomes on neuronal excitability. Mutations in the FGF14 gene in humans have been associated with brain disorders that are partially recapitulated in Fgf14–/– mice. Thus, signaling pathways that modulate the FGF14:Nav channel interaction may be important therapeutic targets. Bioluminescence‐based screening of small molecule modulators of the FGF14:Nav1.6 complex identified 4,5,6,7‐tetrabromobenzotriazole (TBB), a potent casein kinase 2 (CK2) inhibitor, as a strong suppressor of FGF14:Nav1.6 interaction. Inhibition of CK2 through TBB reduces the interaction of FGF14 with Nav1.6 and Nav1.2 channels. Mass spectrometry confirmed direct phosphorylation of FGF14 by CK2 at S228 and S230, and mutation to alanine at these sites modified FGF14 modulation of Nav1.6‐mediated currents. In 1 d in vitro hippocampal neurons, TBB induced a reduction in FGF14 expression, a decrease in transient Na+ current amplitude, and a hyperpolarizing shift in the voltage dependence of Nav channel steady‐state inactivation. In mature neurons, TBB reduces the axodendritic polarity of FGF14. In cornu ammonis area 1 hippocampal slices from wild‐type mice, TBB impairs neuronal excitability by increasing action potential threshold and lowering firing frequency. Importantly, these changes in excitability are recapitulated in Fgf14–/– mice, and deletion of Fgf14 occludes TBB‐dependent phenotypes observed in wild‐type mice. These results suggest that a CK2‐FGF14 axis may regulate Nav channels and neuronal excitability. —Hsu, W. ‐C. J., Scala, F. , Nenov, M. N. , Wildburger, N. C. , Elferink, H. , Singh, A. K. , Chesson, C. B. , Buzhdygan, T. , Sohail, M. , Shavkunov, A. S. , Panova, N. I. , Nilsson, C. L. , Rudra, J. S. , Lichti, C. F. , Laezza, F. CK2 activity is required for the interaction of FGF14 with voltage‐gated sodium channels and neuronal excitability. FASEB J. 30, 2171–2186 (2016). www.fasebj. org
Biobased materials for polyurethane dispersions

Nowadays, most of the commercially available resins are synthesized from petroleum based stocks. Besides exhibiting excellent properties, synthetic resins are coming under increasing restrictions due to tightening environmental exposure regulations, high depletion rates and exponential rising prices of petrochemical stocks etc. So, considering an increasing ecological and economical issue in the new generation coating industries, the maximum utilization of naturally available resources for polymer/resin synthesis can be an obvious option. These renewable resources can be utilized for number of polymerization reactions due to their reactive functionalities such as hydroxyl groups, carboxyl groups, unsaturation, reactive phenolic structures etc. Therefore, a wide variety of resins can be synthesized from renewable resources, some of them being, alkyd, polyesters, phenolic resins, epoxy resins, polyurethanes, acrylics, vinyl, etc. The present paper discussed the potential of naturally available resources as an environment friendly alternative for petroleum based raw materials as far as coating industries are concerned.
Les propriétés homologiques des algèbres elliptiques de petite dimension

Cette these est consacree a l'etude des proprietes homologiques d'une famille d'algebres associatives attachee aux courbes elliptiques. Chaque algebre de cette famille admet un nombre ni de generateurs subordonnes aux relations quadratiques. Elles sont aujourd'hui connues sous le nom d'algebres elliptiques de Sklyanin-Odesskii- Feigin. Il convient toutefois de souligner que le cas le plus simple, la famille d'algebres elliptiques avec trois generateurs, etait deja connue de Artin et Shelter.
Perceived Efficiency and Use of Strategies for Emotion Regulation

A total of 819 students, 208 women and 210 men from Norway and 201 women and 200 men from Brazil, of whom 76.9% were in the 20- to 29-yr. age range, rated the use and efficiency of 14 strategies in regulation of emotion aimed at stopping anger, anxiety, and sadness. The same strategies were rated as most frequently used in both cultures for all three negative emotions. The most used strategies were “talking to somebody” and “saying something to oneself. ” Used strategies were rated as more efficient than nonused strategies; cultural variation in use of strategy was consistent with the distinction between individualism and collectivism and women's ratings supported prior research on confidence in emotions by showing use of more strategies for anxiety and sadness than men's. Ratings from an outpatient sample of 80 women (M age = 25.5 yr., SD = 4.4) and 80 men (M age = 25.4 yr., SD = 4.1) supported expectations that there would be differences between nonpatients and patients based on diagnostic characteristics of depression and anxiety.
Allele frequency distribution for the variable number of tandem repeat locus D10S28 in Tamil Nadu (South India) population

Allele frequencies were determined in unrelated individuals of Tamil speaking population from the Madras City (Tamil Nadu, South India) area for the polymorphic DNA locus D10S28 using the probe TBQ7. Membranes hybridized with the probe YNH24 were subjected to deprobing and were subsequently hybridized with random priming – labeled, purified inserts of TBQ7. The sizes of the fragments were grouped to 100 bp as well as to arbitrary fixed bins (Federal Bureau of Investigation/Royal Canadian Mounted Police). There were 14 bins in the latter with the most common bin being 11 (1789–1924 bp) with a frequency of 9.8%. We observed a heterozygosity of 92% comparable to Caucasian populations. The data presented here can be used as the basis for utilizing this variable number of tandem repeats (VNTR) DNA marker for paternity determinations and forensic investigations.
Intraoperative Risk Factors Associated With Postoperative Pressure Ulcers in Critically Ill Patients: A Retrospective Observational Study*

Objective:The risk for pressure ulcers is rarely identified in the perioperative period, and the influence of this period on risk factors has not been as rigorously studied as the postoperative period. We hypothesized that intraoperative risk factors exist, which increase the likelihood of a postoperative new-onset pressure ulcer. Design:A retrospective observational study. Setting:A large midwestern U.S. quaternary care institution. Patients:A total of 2,695 adult surgical patients underwent operative procedures and received care in one of three ICUs using an electronic documentation application. Interventions:None. Measurements and Main Results:The primary outcome was hospital-acquired pressure ulcer categorized as stages II, III, and IV; deep tissue injury; or unstageable. Univariate analyses comparing patients with and without the outcome of pressure ulcers were conducted for each preoperative characteristic or comorbidity. Patients were matched using the logit of the propensity score based solely on their preoperative comorbidities. Adjusted associations between development of pressure ulcers and intraoperative characteristics were determined in the postmatch cohort. We identified seven independent preoperative patients’ characteristics and comorbidities in our adult surgical patient sample: American Society of Anesthesiologists risk classification 4 or 5, underweight body mass index, noncardiac surgery, history of congestive heart failure, renal disease, existing airway present prior to arrival in the operating room, and age. The only significant association in the matched dataset accounting for patient preoperative variability is the use of intraoperative blood products. Conclusion:Postoperative pressure ulcers developed in 10.7% of critically ill patients in our study. Only intraoperative use of blood products, not operative case length, hypotension, or vasopressor use, was associated with postoperative pressure ulcer development on adjusted analysis.
The Deadly Combination of Heat and Humidity in India and Pakistan in Summer 2015

Author(s): Wehner, M; Stone, D; Krishnan, H; Achutarao, K; Castillo, F | Abstract: © 2016 American Meteorological Society. We find that the deadly heat waves in India and Pakistan in 2015 were exacerbated by anthropogenic climate change. Although the impacts of both events were severe, the events themselves were not connected to each other.
The Effect of Ibuprofen on Serum Digoxin Concentrations

This study was undertaken to determine the effects of ibuprofen (Motrin), in daily doses of at least 1600 mg, on steady-state digoxin concentrations. A total of 12 ambulatory patients (10, female; 2, male), with a mean age of 66 years (38–81 yr), completed the study. An initial baseline serum digoxin level was obtained, with follow-up levels at 7 days and, whenever possible, 28 days after ibuprofen initiation. Serum creatinine concentrations were not significantly different from baseline to 7 or 28 days of ibuprofen therapy. Results show a statistically significant (p < 0.05) increase in digoxin levels after seven days of ibuprofen. The mean increase was 59 percent (range, 10.7–325.4 percent), with 10 of the 12 patients displaying increased seven-day levels. Digoxin levels drawn 28 days after ibuprofen initiation were not statistically different from baseline or seven-day digoxin levels.
Effect of Ambient Temperature on Reproductive and Physiological Traits of Nigerian Indigenous Chickens

Genetic adaptation and response to selection depend on genetic variation within and between populations, whereas characterization of the population is a first step towards its improvement. This study demonstrates that variation in genotypes observed in reproductive performance observed among the Nigeria indigenous chicken under the tropical ambient temperature could be explained by the difference observed in the seminal plasma biochemical parameters evaluation. A total of Sixty (60) adult local breeding cocks comprising of 20 normal, 20 frizzle and 20 naked neck cocks were selected randomly from the poultry breeding unit of Teaching and Research farm Ambrose Alli University Ekpoma. Semen was collected from them using abdominal massage technique and analyzed for semen characteristics. The normal feathered cocks had the highest values of rectal temperature (RT), respiratory rate (RR), pulse rate (PR) and heat stress index (HSI) while the least was observed among the naked neck cocks. The semen pH for all the strains was slightly alkaline and ranged from 8.30±0.62 for normal-feathered to 7.49±0.05 for naked neck of the Nigerian local cocks. On Semen motility, normal feather cocks had the highest (P<0.05) value with a mean value of 97.55±1.16%, while the frizzled cocks had the least value of 60.99±0.05% respectively. Normal feathered cocks had the highest value of calcium (Ca ++ ) and albumin (Alb), naked neck with the highest level of total protein (TP), phosphorus (P) and total cholesterol (TC) while the frizzled feathered chicken performed better in terms of sodium (Na + ) and glucose (Glu). However both naked and frizzled feathered cocks had higher values of seminal plasma potassium (K + ) and chlorine (Cl - ). Pairwise correlations of the semen characteristics ranged from low to high values. From factor analysis with varimax rotation of the intercorrelated traits, two principal components (PC) which accounted for 84.13% of the variation in motility chicken semen were extracted. The difference observed could be exploited in management, conservation and selection decision under tropical decisions.
Electrostatically defined serial triple quantum dot charged with few electrons

Max-Planck-Institut fu¨r Festk¨orperforschung, Heisenbergstrase 1, 70569 Stuttgart, Germany. (Dated: February 4, 2008)A serial triple quantum dot (TQD) electrostatically deﬁned in a GaAs/AlGaAs heterostructure ischaracterized by using a nearby quantum point contact as charge detector. Ground state stabilitydiagrams demonstrate control in the regime of few electrons charging the TQD. An electrostaticmodel is developed to determine the ground state charge conﬁgurations of the TQD. Numericalcalculations are compared with experimental results. In addition, the tunnelingconductance throughall three quantum dots in series is studied. Quantum cellular automata processes are identiﬁed,which are where charge reconﬁguration between two dots occurs in response to the addition of anelectron in the third dot.
Study on the distribution characteristics of affected myocardium in non-compaction of left ventricular myocardium

Objectives: This study aims to investigate the distribution characteristics of the diseased area in non-compaction of left ventricular myocardium. Methods: In combination with the standardized myocardial segmentation of the American Heart Association, color Doppler ultrasound was used to analyze the occurrence of lesions in each segment of left ventricular walls in 21 patients with non-compaction of left ventricular myocardium. Results: The distribution characteristics in the lesions area in non-compaction of left ventricular myocardium were as follows: lesion rate in the apical tip was the highest (100%), followed by the lower and side walls of the apical segment, and the mid-cavity segments. Conclusions: Standardized myocardial segmentation is of great significance for the diagnosis of noncompaction of ventricular myocardium (NVM). Apical tip involvement is one of the sensitive and important bases of the ultrasonic diagnosis of this disease.
ADEQUAÇÃO DO VALOR JUSTO NA MENSURAÇÃO DOS ATIVOS BIOLÓGICOS EM EMPRESAS LISTADAS NA BM&FBOVESPA

Devido à convergência das normas brasileiras com as normas internacionais de contabilidade e a adoção do Pronunciamento Técnico CPC 29 Ativos Biológicos e Produtos Agrícolas para as empresas de capital aberto em 2010, uma das principais mudanças encontra-se forma de mensuração do ativo biológico, que passou do método de custo para o método de valor justo. Dessa forma, o presente artigo tem como objetivo verificar a conformidade do conteúdo das notas explicativas das empresas que negociam ativos biológicos com o referido regulamento, bem como o nível de significância estatística entre o tamanho das empresas e seu disclosure. Foi analisada uma amostra de 33 empresas listadas na BM&FBOVESPA, no período de 2010 a 2014, por meio de um estudo qualitativo e descritivo através da análise das notas explicativas das referidas organizações. Com o resultado obteve-se: a constatação de que as empresas analisadas não estão atendendo a totalidade das exigências trazidas pelo CPC 29, tal como alguns dos requisitos exigidos pela norma não foram apresentados nas notas explicativas. Além disso, verificou-se ainda o poder explanatório do ativo total ao comportamento das empresas em divulgar as informações exigidas pelo CPC 29. Por conseguinte, analisou-se o poder explanatório do ativo total sobre o disclosure da informação e se esta variável se apresentaria estatisticamente significante ao modelo de avaliação adotado no estudo. Em síntese, conclui-se que o tamanho da empresa (ativo total) é relevante e explica parte do comportamento das entidades quanto à divulgação das informações exigidas pelo CPC 29.
Diagnosis of scan chain failures

This paper first analyzes faulty scan chain behaviors. In addition to stuck-at faults, we also consider timing faults due to hold time violations Test sequences to determine the fault types in a failing scan chain are presented. This is followed by a presentation of two scan design techniques that simplifies scan chain fault diagnosis for both stuck-at and timing faults.
The Spammer , the Botmaster , and the Researcher : on the Arms Race in Spamming Botnet Mitigation-Major Area Exam

Spam, or Unsolicited Bulk Email, is a big problem in nowadays internet. Recent studies report that spam accounts for more than 90% of the worldwide email traffic [40]. Spam is not only annoying for users, who receive content they did not request, but is also a burden for the whole email delivery infrastructure, that needs to keep delivering legitimate emails with a short delays, but also make sure that unsolicited messages are detected and blocked. Spam can have different goals, from carrying out scams to spread malware with malicious email attachments. However, one of the most common types of spam is the one that promotes e-commerce sites selling illicit goods, such as pharmaceutical products or counterfeit watches and accessories. The e-commerce sites selling such products present the same functionalities of popular legitimate sites (e.g., Amazon), and offer customer service, daily deals, and even refunds if the user is not satisfied. The reason of this is that the cybercriminals behind such sites want to appear as legitimate as possible. Also, unlike what people commonly think, these sites are not scamming their users, and the purchased goods are actually delivered to the recipients [30, 36]. Whether the drugs produces by these companies are equivalent to the branded ones or not is an open question. Large spam e-commerce sites offer affiliate programs (partnerka in Russian) [51]. People who join these affiliate programs send spam through their own email delivery infrastructures, and receive a cut of the revenue in exchange for their services. Past research showed that spam e-commerce sites are quite profitable, with estimates going from $300,000 to $1 Million a month for a large affiliate site [29, 30]. The operations of spam e-commerce involve parties located in most parts of the world, from the domain registrars, to the hosting providers, to the banks processing the payments [36]. For this reason, although many countries have good anti-spam laws, effectively fight them on the law side is hard. Nowadays, most of worldwide spam is sent by botnets, which are networks of compromised computers that act under the control of a single entity, the so called botmaster. Recent reports show how botnets are responsible for 85% of worldwide spam [59]. Botnets
The safety of foods developed by biotechnology.

Recombinant DNA techniques are now being used to develop new plant varieties that will be sources of foods, such as fruits, vegetables, grains, and their by-products. These techniques enable developers to make specific genetic modifications in plants, including modifications that introduce substances into plants that could not be introduced by traditional methods. To ensure the safety of the resulting foods and to foster innovation, the FDA is taking the initiative, before foods from such plants are ready to enter the market, to see that there is an agreed upon scientific basis to evaluate the safety of whole foods and animal feeds derived from new plant varieties. Here, the authors summarize their regulatory framework and their approach to safety assessment and discuss its scientific basis. Their safety assessment approach addresses new varieties of food crops developed by both traditional and newer methods of genetic modification and provides guidance on how safety issues should be addressed.
Concordance between mothers' reports and children's self-reports of depressive symptoms: a longitudinal study.

OBJECTIVE Developmental factors and maternal depression were examined for their impact on mother-child and clinician-child agreement concerning children's internal depressive symptoms. METHOD Data were derived from a clinically referred, racially mixed sample of school-age boys and girls (n = 113), with a study entry diagnosis of depression. Measures of agreement were based on parallel items from the self-rated Children's Depression Inventory, mother-rated Child Behavior Checklist, and clinician-rated, semistructured psychiatric interview with both the child and mother. Repeated measures of agreement were modeled longitudinally over a maximum of 7 years as a function of age, social-cognitive development, and maternal depression. Additional covariates were maternal psychopathology (excluding depression), socioeconomic status, and child's gender and verbal ability. RESULTS Mother-child and clinician-child agreement increased as a function of the child's age during the follow-up and was consistently attenuated by maternal depression. Depressed mothers overrated their children's symptomatology as compared with the children's self-reports. CONCLUSIONS Clinicians should consider the young patient's age and level of maternal depression when weighing the relative merits of self-report and parental report of the child's depressive symptoms. Additional research is necessary to understand the mechanisms of change in parent-child agreement.