Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of dietary methylmercury on liver and kidney histology in the neotropical fish Hoplias malabaricus

Methylmercury is a potent toxic present in Amazonian fish species due to gold mining activities. In the present work, we investigated the morphological effects of methylmercury in liver and kidney of Hoplias malabaricus feeding contaminated prey fish over 70 days. Two groups of nine mature fish (tested and control) were acclimatized for four weeks to laboratory conditions and then the tested group fed prey fish previously contaminated at an additional level of 0.075 mg MeHg g 1 at 5-day intervals and over 14 successive intervals whereas control group fed uncontaminated fish. H. malabaricus specimens were then dissected for chemical and morphological analyses. The low and realistic level of MeHg in the prey fish induced a low increase of total mercury in liver (1.8-fold) and muscle (2.2-fold). The biomagnification factor (Hg in predator/Hg in prey) reached 142 in liver and 21 in muscle and was indicative of a relatively fast contamination of internal organs by dietary exposure. The liver of exposed individuals presented leukocyte infiltration, increased number of melano-macrophage centers, necrotic areas and lesions in Disse’s space. Evident disorder and chaos in cytoskeleton organization suggest a strong toxic effect in hepatocytes, such as organelles positioning and movement, vesicles traffic and secretion. Head kidney showed large necrosis areas, increased number of melano-macrophages centers, phagocytic areas, intercellular space among parenquimal cells and atypical cells. Injuries and damages to tissues suggest too slow defense mechanisms to immobilize or eliminate ingested methylmercury, demonstrating that the sensitivity of fish cells to methylmercury exposure is higher than it has been previously described in the literature. r 2006 Elsevier Inc. All rights reserved.
NLP@UNED at SMM4H 2019: Neural Networks Applied to Automatic Classifications of Adverse Effects Mentions in Tweets

This paper describes a system for automatically classifying adverse effects mentions in tweets developed for the task 1 at Social Media Mining for Health Applications (SMM4H) Shared Task 2019. We have developed a system based on LSTM neural networks inspired by the excellent results obtained by deep learning classifiers in the last edition of this task. The network is trained along with Twitter GloVe pre-trained word embeddings.
Baby Boomer Health Dynamics: How Are We Aging?

Are the baby boomers in Canada more or less healthy than previous generations? What are the implications of this for the national health care system? Baby Boomer Health Dynamic responds to the growing interest in the generation that makes up over one-third of the Canadian population - the largest segment of society - with the leading edge reaching their sixty-fifth birthday in 2011 and eighty-five by 2031. Focusing on four health behaviours that have been proven to be major risk factors for disease: smoking, unhealthy exercise, obesity, and heavy drinking - Andrew V. Wister researches the long-term implications of several key lifestyle-health conundrums, most notably the paradoxical relationship in the concurrent trends over the last two decades of increased exercise levels and a significant rise in obesity. This invariably leads to questions about the eating habits of North Americans, and in particular, the quantity and quality of fast-food and convenience-food consumption. Recent public declarations by a number of health organizations and institutes that we are experiencing an obesity crisis, and moreover, that obesity is the 'new tobacco' makes Baby Boomer Health Dynamics both timely and topical.
Canadian Water Quality Guidelines for the Protection of Aquatic Life HEXACHLORO-BUTADIENE

exachlorobutadiene (HCBD) has a CAS nam and number of 1,1,2,3,4,4,-hexachloro-1,3 butadiene and 87-68-3, respectively. It has chemical formula of C4Cl6 (Howard et al. 1991), is sparingly soluble in water (3.2 mg ⋅L at 25oC) (Gradiski et al. 1975), and has a log K ow of 4.9 (Chiou 1985). HCBD is prepared from hexyl oxide, polychlorobutane hexachlorobutene, or butadiene (Mumma and Lawle 1975; IARC 1979; CESARS 1995). It was mostly used a solvent for longer-chain hydrocarbons and elastome as a hydraulic fluid, a heat transfer liquid and insulati fluid, and as a chemical intermediate in producin chlorofluorocarbons and lubricants. HCBD was also us to recover chlorine-containing gas in chlorine plan (IARC 1979; USEPA 1980; Manahan 1992; WHO 1994
ANTIBACTERIAL EFFECT OF SILVER NANOPARTICLES SYNTHESIZED USING CURCUMA AROMATICA LEAF EXTRACT

This article reports an ecofriendly approach for the synthesis of Ag nanoparticles (Ag NPs) using aqueous leaf extract of Curcuma aromatica. The synthesized Ag NPs were characterized using UV-visible spectroscopy, FTIR, XRD and TEM analyses. UV–Visible spectra of the aqueous medium containing Ag NPs showed a gradual decrease of the absorbance peak observed at 442 nm. The biomolecules responsible for the reduction of Ag NPs were analyzed by FTIR. XRD result confirmed the presence of AgNPs with FCC crystal structure. The calculated crystalline size using Scherrer formula is in the range from 20 to 80 nm. TEM analysis ascertained spherical nature of the Ag NPs. The synthesized Ag NPs exhibited good antibacterial performance against gram-positive and gramnegative bacteria strains, which was studied using standard disc diffusion method. The synthesis of Ag NPs by this method is rapid, cost effective and can be used for various applications.
Phonetic-to-lexical mapping in listening to adult and child speech

The mapping of phonetic information to lexical representations in adult and child speech was examined using cross-modal priming. Native adult listeners were presented with German word fragments (e.g., Parafrom Parasit, ‘parasite’) that mismatched in the second vowel with a visual target word (e.g., Parodie, ‘parody’). Word fragments were spoken by a female adult speaker or a 7-year-old child. Overall, response times were faster following fragment primes spoken by the child. For word pairs with the vowels /uː/, /iː/, and /aː/, fragments spoken by the adult speaker primed target recognition with a directional asymmetry, while no priming was found for fragments spoken by the child speaker. This suggests that phonetic-to-lexical mapping is possibly sensitive to the age of the speaker. The results are interpreted as an effect of previous experience with the linguistic competence of child and adult speakers.
Respiratory innate immune factors regulate steroid-resistant airway hyperreactivity and asthma

16 Chapter 1: Introduction.18 1.1 Overview of Asthma Disease.19 1.2 Immunology of Asthma.19 1.3 Asthma Management.24 1.3.1 Glucocorticoids.25 1.3.1.1 Molecular Basis of GC Function . 26 1.3.1.1.1 GC Receptor Structure and Expression . 26 1.3.1.1.2 GR Nuclear Translocation . 28 1.3.1.1.3 GRs and Gene Transcription.29 1.4 Asthma and Steroid Resistance.31 1.4. 1 Steroid Resistant Asthma.31 1.4. 2 Molecular Basis of Steroid Resistance.33 1.4. 2.1 Defect of GRs Expression and Ligand Binding.33 1.4. 2.2 Impaired GRs Nuclear Translocation and GR-GRE Binding. 34 1.4. 2.3 Crosstalk with Other Transcription Factors. 35 1.5 Asthma Phenotype.36 1.5.1 Non-eosinophilic Asthma.37 1.5. 2 Innate Immune Response in Steroid Resistant Asthma.37 1.5. 3 Infection and Asthma.38 1.5. 3.1 Toll-like Receptors (TLRs). 39 1.5. 4 Interferon-(IFN-). 42 6 1.5. 5 Chemosensors and Asthma.43 1.5. 5.1 Olfactory Receptor (OR) . 44 1.5. 6 Innate Immune Cells.46 1.5. 6.1 Macrophages.46 1.5. 6.2 Alveolar Macrophages.47 1.5. 6.3 Macrophage Polarization. 48 1.5. 6.4 Macrophage Recruitment and Chemotaxis . 49 1.6 MicroRNAs in Immune Response and Asthma.50 1.6.1 Biogenesis of microRNA.50 1.6.2 Modulation of miRNAs Expression. 52 1.6.3 Emerging Role of microRNA in Asthma.52 1.6.4 Therapeutic Potential of Targeting miRNAs as New Approach to Treat Asthma.55 1.7 Study rational.55 Chapter 2: IL-27/IFN-Induce MyD88Dependent Steroid-Resistant Airway Hyperresponsiveness by Inhibiting Glucocorticoid Signalling in Macrophage.57 2.1 Abstract.58 2.2 Introduction.58 2.3 Materials and Methods.62 2.3.1 Animals.62 2.3. 2 Administration of IL-27, IFN-, and/or LPS, and Ab neutralization of IL-27.63 2.3. 3 Analysis of induced sputum samples from human asthma patients.63 2.3. 4 Administration of dexamethasone.64 2.3. 5 Measurement of lung function.65
CRURO-PEDAL STRUCTURE OF THE PAULCHOFFATIID RUGOSODON EURASIATICUS AND EVOLUTION OF THE MULTITUBERCULATE ANKLE

Here we describe the osteological structures of the lower hind limb and foot of the Late Jurassic Rugosodon eurasiaticus, the earliest-known postcranial fossil of a multituberculate mammal. This fossil extends the key cruro-tarsal apomorphies, previously known from multituberculates of the Cretaceous and Paleogene, to the paulchoffatiid multituberculates of the Jurassic. Multituberculates as a group can now be diagnosed by derived features of the astragalus, the navicular, and the entocuneiform. These features are correlated with the mobility of the upper ankle joint and pedal digit I, indicating that early multituberculates acquired new locomotor functions of the limb and foot. However, the standing pedal posture of the basal multituberculates is plantigrade, typical of primitive mammaliaforms. The digitigrade posture appeared later in derived multituberculates of the Late Cretaceous and Paleogene, and was accompanied by several derived features of the calcaneus: elongation of the calcaneal tuber, development of the peroneal process and groove, and medio-lateral compression of the proximal part of calcaneus. These derived features enhanced locomotor function by increasing the in-lever of the Achilles muscles to lift the calcaneal heel off the substrate. The derived calcaneo-cuboidal features also facilitated a wider range of movement (including abduction) of the distal pedal elements. We concur that derived multituberculates may have had digitigrade pedal posture, although only facultatively. New fossils of the Jurassic Rugosodon and Early Cretaceous Sinobaatar have revealed fresh evidence that the astragalar features of the earliest paulchoffatiids are correlated with sophisticated cruro-tarsal rotation as in other multituberculates. Rugosodon provides the ancestral condition from which more diverse calcaneal features for more versatile functions evolved in geologically younger and more derived multituberculates.
DIGITAL DATA PROTECTION USING STEGANOGRAPHY

In today’s digital world applications from a computer or a mobile device consistently used to get every kind of work done for professional as well as entertainment purpose. However, one of the major issue that a software publisher will face is the issue of piracy. Throughout the last couple of decades, almost all-major or minor software has been pirated and freely circulated across the internet. The impact of the rampant software piracy has been huge and runs into billions of dollars every year. For an independent developer or a programmer, the impact of piracy will be huge. Huge companies that make specialized software often employ complex hardware methods such as usage of dongles to avoid software piracy. However, this is not possible to do for a normal independent programmer of a small company. As part of the research, a new method of software protection that does not need proprietary hardware and other complex methods are proposed in this paper. This method uses a combination of inbuilt hardware features as well as steganography and encryption to protect the software against piracy. The properties or methods used include uniqueness of hardware, steganography, strong encryption like AES and geographic location. To avoid hacking the proposed framework also makes use of self-checks in a random manner. The process is quite simple to implement for any developer and is usable on both traditional PCs as well as mobile environments.
Novel Interaction Cost Analysis Applied to Bank Charges Calculator

This paper presents an online calculator for bank charges, motivated by information asymmetry in the market for payment accounts. The calculator provides users with a personalized list of the most suitable bank accounts based on required services and monthly fee criteria. This paper outlines the conceptual foundation, workflows, and matrix of the data for the underlying logic of the calculator, as well as the design of the user interface. The proposed calculator was validated by performing an interaction cost analysis. This paper presents a novel methodology for conducting this analysis, including rules for expressing interactions in graphs for the objective evaluation of the usability of the user interface. Scenarios were defined and analyzed with the intended goal of choosing the best bank account. The interaction cost analysis then confirmed the differences in cost between traditional approaches (interacting with various web interfaces) and using a specialized online service (the calculator). The consistency of the layout and navigation contributed significantly to the final results being in favor of the proposed bank charges calculator. These conclusions are applicable not just within the selected market, but also in many others that are prone to problems arising from price information asymmetry.
Improving Surface-syntactic Universal Dependencies (SUD): MWEs and deep syntactic features

SUD is an annotation scheme for syntactic dependency treebanks, near isomorphic to UD (Universal Dependencies). Contrary to UD, it is based on syntactic criteria (favoring functional heads) and the relations are deﬁned on distributional and functional bases. In this paper, we will recall and specify the general principles underlying SUD, present the updated set of SUD relations, discuss the central question of MWEs
Overcoming sustainability barriers through Formalized Network Contracts (FNCs): the ex- perience of Italian SMEs

(Article begins on next page) Anyone can freely access the full text of works made available as "Open Access". Works made available under a Creative Commons license can be used according to the terms and conditions of said license. Use of all other works requires consent of the right holder (author or publisher) if not exempted from copyright protection by the applicable law. Availability: This is the author's manuscript
Shadowing with glass figures ? A comparative analysis of committee chair powers in Western European democracies

Recent work on coalition governance argues that government parties use the chairs of parliamentary committees to monitor their coalition partners. To support this claim, they show that ministers are often ‘shadowed’ by committee chairs from other coalition parties. The link between the theoretical argument and the empirical evidence rests on the empirically largely neglected assumption that committee chairs enjoy special powers (beyond those enjoyed by every committee member) to monitor ministers and affect policy-making in the committee. The paper tests this assumption based on the first comparative measure of committee chair powers in fifteen Western European democracies. The analysis shows that most committee chairs have very limited formal powers and that the share of shadowing chairs does not increase when committee chairs are more powerful. Both findings cast doubt on the interpretation of shadow chairs as a monitoring instrument to control coalition partners. Instead, we offer an alternative explanation according to which coalition parties employ the shadowing strategy in order to increase public visibility and counteract issue ownership by the minister’s party. Beyond the question of shadowing, we show that chair powers tend to be negatively related to committee strength which indicates that parliamentary actors are less inclined to accept internal hierarchy if the stakes are higher.
Munc 13 ‐ 4 mediates human neutrophil elastase ‐ induced airway mucin 5 AC hypersecretion by interacting with syntaxin 2

The overexpression and hypersecretion of mucus is a hallmark of chronic pulmonary inflammatory disease. Mucin5AC (MUC5AC) is a major component of airway gel‐forming mucin. Members of the Unc13 (Munc13) protein family act as important activators of granule exocytosis from various types of mammalian cells. The present study aimed to determine the role of Munc13 family proteins in MUC5AC secretion via an in vitro study with BEAS‐2B and Calu‐3 cell lines. Reverse transcription‐quantitative polymerase chain reaction and western blotting indicated that stimulation of the cells with 100 nM human neutrophil elastase (hNE) for 1 h did not affect the expression of either unc13 homolog B (Munc13‐2) or unc13 homolog D (Munc13‐4), but immunofluorescence analysis demonstrated that hNE treatment was associated with the recruitment of Munc13‐4 to the plasma membrane. Co‐immunoprecipitation analysis indicated increased binding between Munc13‐4 and syntaxin2 followingh NE stimulation; however, Munc13‐2 formed a stable interaction with syntaxin2 with or without hNE stimulation. Subsequently, Munc13‐2 and Munc13‐4 expression levels were downregulated in BEAS‐2B and Calu‐3 cells using small interfering RNA (siRNA). ELISAs and immunofluorescence analysis were performed to assess MUC5AC secretion and intracellular retention, respectively. Munc13‐2 siRNA transfection did not alter the expression levels of intracellular or secreted MUC5AC following hNE stimulation in either cell line; however, it increased the baseline intracellular levels of MUC5AC and decreased the amount of secreted MUC5AC. Conversely, Munc13‐4 siRNA transfection increased the intracellular levels of MUC5AC and decreased the amount of secreted MUC5AC following hNE stimulation, but did not affect their baseline quantities. The results of the present study indicate that Munc13‐2 may be an essential regulator of basal MUC5AC exocytosis, while Munc13‐4 appears to be a Munc13 protein subtype that may to be sensitive to hNE stimulation during airway MUC5AC hypersecretion.
Phylogenetic evidence euggeete a later origin of the DRD 2 l and DRD 4 re dopamine receptor gene lineagee

Dopamine receptore are integral membrane proteine whoee endogenoue ligand ie dopamine. They play a fundamental role in the central nervoue eyetem and dyefunction of dopaminergic neurotranemieeion ie reeponeible for the generation of a variety of neuropeychiatric dieordere. From an evolutionary etandpoint, phylogenetic relationehipe among the DRD1 claee of dopamine receptore are etill a matter of debate ae in the literature different tree topologiee have been propoeed. In contraet, phylogenetic relationehipe among the DRD2 group of receptore are well underetood. Underetanding the time of origin of the different dopamine receptore ie aleo an ieeue that neede further etudy, eepecially for the genee that have reetricted phyletic dietributione (e.g. DRD2l and DRD4re). Thue, the goal of thie etudy wae to inveetigate the evolution of dopamine receptore, with emphaeie on ehedding light on the phylogenetic relationehipe among the D1 claee of dopamine receptore and the time of origin of the DRD2l and DRD4re gene lineagee. Our reeulte recovered the monophyly of the two groupe of dopamine receptore. Within the DRD1 group the monophyly of each paralog wae recovered with etrong eupport, and phylogenetic relationehipe among them were well reeolved. Within the DRD1 claee of dopamine receptore we recovered the eieter group relationehip between the DRD1C and DRD1E, and thie clade wae recovered eieter to a cycloetome eequence. The DRD1 clade wae recovered eieter to the aforementioned clade, and the group containing DRD5 receptore wae eieter to all other DRD1 paraloge. In agreement with the literature, among the DRD2 claee of receptore, DRD2 wae recovered eieter to DRD3, whereae DRD4 wae eieter to the DRD2/DRD3 clade. According to our phylogenetic tree, the DRD2l and DRD4re gene lineagee would have originated in the anceetor of gnathoetomee between 615 and 473 mya. Coneervation of eequencee required for dopaminergic neurotranemieeion and emall changee in regulatory regione euggeet a functional refinement of the dopaminergic pathwaye along evolution. 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33
WHEN THE GOING GETS TOUGH , THE TOUGH GET GOING This satellite symposium took place on 13 th June 2015 as part of the 25 th European Meeting on Hypertension and Cardiovascular Protection in Milan , Italy Chairperson

Disclosure: Massimo Volpe has received advisory board fees from Daiichi Sankyo Europe GmbH and speaker honoraria from the Menarini Group and Daiichi Sankyo Europe GmbH. Josep Redòn has been a speaker for Menarini International, Daiichi Sankyo, MSD, and Boehringer Ingelheim, and has participated on advisory boards for Daiichi Sankyo. Michel Burnier has received research grants, speaker fees, and consultancy fees from Daiichi Sankyo and the Menarini Group. Acknowledgements: Writing assistance was provided by Dr Ana Rodríguez de Ledesma, apothecom scopemedical Ltd. Support: The symposium was organised by the Menarini Group and Daiichi Sankyo Europe GmbH. Authors received honoraria for preparation and delivery of their presentations. The views and opinions expressed are those of the authors and not necessarily of the Menarini Group and Daiichi Sankyo Europe GmbH. Citation: EMJ Cardiol. 2015;3(Suppl 4):2-9.
Home Health Telecare : Proposal of an Architecture for Patient Monitoring and Critical Situation Detection

-The development of medical remote care applications is crucial due to the general aging of the population and the likelihood of a doctor shortage in the future. This paper deals with the concept of a smart home for health care. It consists in fitting out a flat with multiple sensors and analysing their output signals closely along with other available information such as clinical data. The aim is to detect unusual situations that might give serious cause for concern. The smart home is connected to a large medical network, which provides a direct link to medical assistance in case of emergency. One of the main issues is to make a decision about the patient state so as to detect both shortand long-term critical evolutions, with a level of seriousness being associated to each detection. The complexity of the decisionmaking process entails building a multiple-level decision architecture. The methods and algorithms related to such a decision-making stem from pattern recognition and neural networks. Specific consideration regarding ethical, social and individual needs is also required.
EVALUATING THE SURVIVABILITY AND SECURITY OF COMPLEX WEB SYSTEMS

The strategy of an organization should include as a main objective the insurance of an optimal performance level for its information systems, which implies the need to define their core capabilities and fundamental quality attributes. The early development, since the design phase, of specific performance evaluation techniques and survivability capacities in different critical situations (attacks) for system operation, adds to the managerial decision-making process a powerful tool for maintaining the system to the expected performance level. This article analyses the survivability (ability to survive) of an application that uses Web technology in a 3-tier architecture through systematic evaluation, at different levels, of the availability in terms of cyber-attack and survival properties of the application.
DNA methyltransferase ( DNMTs ) expression in cervical cancer tissues and its relationship with HPV infection and tumor malignancy

DNA methyltransferase (DNMTs) expression in cervical cancer tissues and its relationship with HPV infection and tumor malignancy Li-Ling Li, Shao-Shuai Wang Department of Gynecology and Obstetrics, Hubei Provincial Hospital of Integrative Chinese and Western Medicine, Wuhan 430015, China Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College of HUST, Wuhan 430022, China Journal of Hainan Medical University