Miracle-dz/UniFAR-FTUs huggingface dataset:
Dementia: many roads, but not built in a day.

The human brain is largely postmitotic, with limited ability for repair or regeneration in response to age- or disease-related neuropathologic alterations. The study by Schneider et al.1 provides a sobering view of our brain’s longevity by showing that the majority of older community-dwelling persons, regardless of the presence or absence of dementia, have significant brain pathology, not just one pathology but several. Schneider et al. examined the brains of 141 volunteers who had undergone careful (longitudinal) clinical screenings for this clinical-pathologic cohort study of aging. They concluded that the majority of these older individuals had neuropathology that could have a functional impact, and that those persons with multiple pathologies were more likely to have overt signs of dementia. As better treatments for non-CNS medical conditions allow our elderly population to live longer, the impact of this age-associated neuropathology should be of concern to neurologists managing geriatric patients. There have been previous studies of aging neuropathology showing significant abnormalities in the brain before dementia develops2–4; …
Cloning and identification of HEM14, the yeast gene for mitochondrial protoporphyrinogen oxidase

A respiratory‐defective mutant (C54) of Saccharomyces cerevisiae was found to have a phenotype consistent with a mutation in either mitochondrial protoporphyrinogen oxidase or ferrochelatase. The mutant is grossly deficient in hemes, accumulates protoporphyrin and is rescued by exogenous heme. The increased levels of protoporphyrin at the expense of heme is indicative of a block in one of the two last steps of the heme biosynthetic pathway. Complementation of C54 by a known ferrochelatase mutant suggested that the defect was most likely in HEM14 encoding protoporphyrinogen oxidase. A plasmid capable of complementing C54 was obtained by transformation with a yeast genomic plasmid library. A partial sequence of the insert identified the gene as reading frame YER014 of yeast chromosome V (GenBank Accession Number U18778). This reading frame codes for a protein homologous to human protoporphyrinogen oxidase. Disruption of this gene elicits a respiratory defect and accumulation of protoporphyrin. The phenotype of the null mutant together with the homology of YER014p to human protoporphyrinogen oxidase provide compelling evidence that YER014 is HEM14.
Template ageing in non-minutiae fingerprint recognition

This study uses non-minutiae fingerprint recognition methods to confirm earlier results on the existence of fingerprint template ageing. We performed the experiments on datasets including a time-span of 4 years. The acquisition was performed by using three different commercial off-the-shelf optical fingerprint sensors. Furthermore, we compared the results of those non-minutiae experiments to investigations performed by a traditional minutiae based approach. The analysis exhibits that there are very similar effects in terms of fingerprint template ageing detectable for all considered recognition methods.
Performance Evaluation for the Two-Stage Cooperative Spectrum Sensing Scheme in Cognitive Radio

In order to obtain more precise spectrum sensing performance in cognitive radio networks, a twostage spectrum sensing approach is investigated. More specifically, a coarse spectrum sensing based on energy detection is introduced in the first stage. When the sensing decision is idle channel by coarse sensing, a fine spectrum sensing based on first order cyclostationary feature detection is exploited in the second stage. Moreover, the problem formulation and discussion of two-stage spectrum sensing is presented. Optimization algorithm is to maximize the throughput under the probability of error sensing constraint. Numerical results show that the sensing performance is improved significantly as opposed to conventional one stage spectrum sensing. Key-Words: cognitive radio; two-stage spectrum sensing; performance evaluation; energy detection; first order cyclostationary feature detection
Silicon-Integrated 2-GHz Fully-Differential Tunable Recursive Filter for MMIC Three-Branch Channelized Bandpass Filter Design

In this paper, a silicon-integrated differential-type two-stage recursive active filter based on a cellular approach is presented. This circuit is independently tunable in terms of power transmission gain, center frequency and bandwidth. The chip surface is less than 1.4 mm2. Measurements demonstrate a 1.9-2.4 GHz center-frequency tuning range with a typical gain of 15 dB and a 3-dB bandwidth of 60 MHz. Gains up to 40 dB and bandwidths as low as 20 MHz are also achievable in the 2.05-2.38 GHz band. In the next step, the design of an integrated three-branch channelized bandpass filter is addressed. To the author's knowledge, this is the first MMIC channelized filter reported to date. The proposed filter uses an active power splitter at its input. Moreover, the branches are based on an elementary tunable recursive stage derived from the topology previously described, thus making the overall filter fully reconfigurable. This second circuit, which chip size is smaller than 3 mm2, can perform 3-dB bandwidths of approximately 90 MHz and gains up to 20 dB within a 2-2.2 GHz tuning range. Controllable high-selectivity for each rejected band is also obtained through the generation of adjustable out-of-band transmission zeros. These two chips have been implemented using Philips QUBIC4 Si BiCMOS process (Szmyd et al., 2001)
Evaluation of routine upper digestive tract endoscopy before laparoscopic cholecystectomy

Endoscopy of the upper digestive tract was performed in 376 patients with symptomatic gallstone disease before elective laparoscopic cholecystectomy. Abnormalities were found in 60 patients (16.0 per cent); these included peptic ulcer (n = 14), gastric erosions (n = 15) and oesophagitis (n = 11). Thirty patients were treated medically and two by endoscopic polypectomy. In four patients endoscopy led to cancellation of cholecystectomy; in two the complaints have persisted. Statistical analysis of 28 variables showed few significant differences in symptoms between patients with normal and those with abnormal appearances at endoscopy. It is concluded that routine endoscopy before laparoscopic cholecystectomy is neither clinically useful nor cost effective in patients with symptomatic gallstone disease. This conclusion is related exclusively to patients with typical gallstone symptoms according to the definition used in this department.
Role of Rho proteins in carbachol‐induced contractions in intact and permeabilized guinea‐pig intestinal smooth muscle.

1. The aim of this study was to determine whether the low molecular mass GTPase RhoA or related proteins are involved in carbachol‐ and high‐K(+)‐induced contractions in intact intestinal smooth muscle as well as the carbachol‐induced increase in Ca2+ sensitivity of the myofilaments in permeabilized preparations. 2. The carbachol‐induced increase in the Ca2+ sensitivity of force production in beta‐escin‐permeabilized intestinal smooth muscle was enhanced in preparations that were loaded with the constitutively active mutant of RhoA, Val14RhoA, and was inhibited by exoenzyme C3 from Clostridium botulinum, which ADP‐ribosylates and inactivates small GTPases of the Rho family. The effect of C3 on Ca2+ sensitivity in the absence of the agonist was negligible, while the maximal Ca(2+)‐activated force was inhibited by about 20%. 3. Inhibition of carbachol‐induced force was associated with an increase in ADP‐ribosylation of a protein band with a molecular mass of approximately 22 kDa, corresponding to Rho, and was partially reversed in the presence of Ile41RhoA, which is not a substrate for C3. Val14RhoA did not restore carbachol‐induced Ca2+ sensitization in C3‐treated smooth muscle. 4. In intact intestinal smooth muscle, toxin B from Clostridium difficile, which monoglucosylates members of the Rho family, inhibited high‐K(+)‐induced contractions and the initial phasic response to carbachol by about 30%. The delayed contractile response to carbachol was completely inhibited. 5. In smooth muscle preparations that were permeabilized with beta‐escin after treatment with toxin B, carbachol‐and GTP gamma S‐induced Ca2+ sensitization was significantly inhibited. 6. These findings are consistent with a role for Rho or Rho‐like proteins in agonist‐induced increase in Ca2+ sensitivity of force production in intact and permeabilized intestinal smooth muscle.
Adolescent obesity in Lebanese private schools.

BACKGROUND Obesity has become a public health problem worldwide. Our objective was to calculate the prevalence of overweight and obesity. METHODS It is a cross sectional study of adolescents in private Lebanese schools, aged 10-18 years. Gender, birth date and measures of weight and height were recorded. RESULTS In 12,299 adolescents, we found high prevalence of obesity (7.5%) and at risk of obesity (24.4%). In girls, risk of obesity and obesity prevalence decrease with increasing age (P < 10(-4)) as compared with that in boys. CONCLUSION Early recognition of obesity should become routine in paediatric ambulatory care settings.
Scalable PD/SOI CMOS with floating bodies

An insightful analysis of the floating-body (FB) effect on off-state current (I/sub off/) in PD/SOI MOSFETs is done based on simulations calibrated to a published scaled SOI CMOS technology (Chau et al., 1997). In contrast to the conclusion drawn by Chau, the simulations reveal that proven, easily integrated processes for enhancing carrier recombination in the source/drain junction region, in conjunction with the normal elevated chip temperature of operation, can effectively suppress the FB-induced increase of I/sub off/, thus enabling exploitation of the unique benefits of scaled PD/SOI CMOS circuits.
Trigeminal Deafferentation and Feeding in the Pigeon: Sensorimotor and Motivational Effects

The role of oral sensations in the control of hunger and thirst in the pigeon was studied in birds in which the trigeminal sensory nerves had been sectioned bilaterally. Trigeminal deafferentation, although it does not impair drinking, disrupts both the neurosensory and the motivational control of feeding behavior. These two types of deficit may be experimentally dissociated.
The Competitiveness of SMK and Diploma 3 Graduates of Hospitality at the Entry Level and Employability Skills in Developing Career Pathways

Along with the development of the ASEAN Economic Community in 2015, Indonesia is required to generate professional human resources in order to compete with other countries, particularly subject to competition in the services sector. Hotel is a product in the hospitality industry that have an important role in the tourism business.Intense competition in the hospitality industry demand the hotels to provide the best service to the customers. Vocational education has a function to prepare a professional and competitive workforce in the industry. The hospitality graduates will be able to fill the existing organizational structure in accordance with the educational background. The Presidential Decree No.8, 2012, Article 5 states that equalizing learning outcomes generated through education with the level of qualification at KKNI. KKNI is intended as a description of outcomes that must be mastered by graduates of vocational education, higher education, vocational training institutions as well as independent study. Graduates of Vocational and D3 of hospitality began their career in the hospitality industry by filling the positions in the organizational structure. In a few of star hotels in Medan, North Sumatra, hospitality graduates of vocational and D3 have competitive power in a very thin difference. Their entry level almost similar to the same position as well as employability skills and technical competence are almost equal that will provide a gap between the educational background of the career pathways that exist in the world of hospitality. It is very wise if there will be collaboration between the hotel industry, the educators, community leaders, and high-level policy makers in generating strategies to enhance the competitiveness of human resources professionals in the hospitality and placed in accordance with the level of education based KKNI.
Goblin (ankyrin) in striated muscle: identification of the potential membrane receptor for erythroid spectrin in muscle cells.

Goblin , a high molecular weight (Mr, 260,000) polypeptide of avian erythrocyte plasma membranes characterized by hormone-dependent phosphorylation, is shown by a variety of criteria to be the avian equivalent of ankyrin, the membrane attachment protein for spectrin; a polyclonal monospecific goblin antiserum reacts specifically with ankyrin from mammalian erythrocyte ghosts; goblin and ankyrin have highly homologous, although distinct, two-dimensional peptide maps; and, in reconstitution experiments, goblin binds to spectrin and band 3 in approximately the same molar ratio as ankyrin. Immunoautoradiography and immunofluorescence with goblin antiserum reveal that a serologically related polypeptide (Mr, 235,000) is present in highly purified membrane fractions of mammalian myocardium and in whole extracts of adult chicken cardiac and skeletal muscle-nonerythroid tissues which express predominantly the erythroid (alpha beta-) spectrin phenotype. Erythroid spectrin and goblin (ankyrin) are codistributed in skeletal muscle at the sarcolemma as discrete foci adjacent to the Z lines and, in pectoral muscle, also at the periphery of the Z discs. These spatial relationships indicate that goblin and spectrin in muscle cells form a structural framework that serves as the attachment site for the myofiber at the level of the Z line on the sarcolemma.
Characterizing genic and nongenic molecular markers: comparison of microsatellites and SNPs

The implications of transitioning to single nucleotide polymorphism (SNPs) from microsatellite markers (MSs) have been investigated in a number of population genetics studies, but the effect of genomic location on the amount of information each type of marker reveals has not been explored in detail. We developed novel SNP markers flanking 1 kb regions of 13 genic (within gene or <1 kb away from gene) and 13 nongenic (>10 kb from annotated gene) MSs in the threespine stickleback genome to obtain comparable data for both types of markers. We analysed patterns of genetic diversity and divergence on various geographic scales after converting the SNP loci within each genomic region into haplotypes. Marker type (SNP haplotype or MS) and location (genic or nongenic) significantly affected most estimates of population diversity and divergence. Between‐lineage divergence was significantly higher in SNP haplotypes (genic and nongenic), however, within‐lineage divergence was similar between marker types. Most divergence and diversity measures were uncorrelated between markers, except for population differentiation which was correlated between MSs and SNP haplotypes (both genic and nongenic). Broad‐scale population structure and assignment were similarly resolved by both marker types, however, only the MSs were able to delimit fine‐scale population structuring, particularly when genic and nongenic markers were combined. These results demonstrate that estimates of genetic variability and differentiation among populations can be strongly influenced by marker type, their genomic location in relation to genes and by the interaction of these two factors. This highlights the importance of having an awareness of the inherent strengths and limitations associated with different molecular tools to select the most appropriate methods for accurately addressing various ecological and evolutionary questions.
Supervisors’ experiences with e-portfolio in pre-service teacher education

This study is part of a larger study that explores how the use of an e-portfolio can improve student teachers’ development of profession related competences in a workplace setting. More specifically, we focus on the potential of an e-portfolio for enhancing and managing feedback provided by supervisors. For this study we collected data from nine school-based and four university-based teacher education internship supervisors about the perceived usability of one assessment e-portfolio which was used during a four-month internship period in which they supervised thirteen student teachers of the final (fifth) year of the primary school teacher curriculum. © 2016 Published by Future Academy www.FutureAcademy. org.uk
Influential Factors on IS Project Quality: A Total Quality Management Perspective

Successful accomplishment of information system (IS) projects is a crucial challenge for researchers and practitioners. Agreement on influential factors, that is, success and failure factors, and on what constitutes success is lacking. Considering process and product quality an integral part of IS project success, we examine how project success and failure factors influence IS project quality. We conducted semi-structured interviews with 19 practitioners involved in IS projects and strategic decision making. This research-in-progress is based on total quality management (TQM), which facilitates continuous improvement of IS project quality. By applying an influential factor framework, we allow for a more detailed examination of success and failure factors not addressed in TQM. Our results suggest quality-specific themes, while acknowledging their context-dependency. By examining IS project quality and applying the influential factor framework, we expect to equip researchers and practitioners with an approach to examine specific dimensions of IS project success in detail.
PROBLEMS FACED BY MICRO, SMALL AND MEDIUM ENTERPRISES IN RAISING DEBT CAPITAL

Finance is one of the most critical inputs for all business enterprise, whether large or small. Sources of finance may be external, such as loans, equity infusions, subsidies and government grants, or internal such as generated from cash flows. This study tries to emphasize the contribution of Micro, Small and Medium Enterprises hereafter (MSMEs) in the Indian economy and draws attention to the problems faced by entrepreneurs of (MSMEs) in raising debt capital.
Process Management A Guide For The Design Of Business Processes

Thank you very much for downloading process management a guide for the design of business processes. As you may know, people have search numerous times for their chosen novels like this process management a guide for the design of business processes, but end up in harmful downloads. Rather than enjoying a good book with a cup of coffee in the afternoon, instead they juggled with some harmful virus inside their laptop.
Nuclear expression of SOX 18 in cancer cells indicates a poor prognosis in patients with hepatocellular carcinoma

Transcription factor SOX18 is involved in the development of many tumors, but SOX18 protein expression in hepatocellular carcinoma (HCC) has not been studied. Thus, we measured SOX18 protein expression in HCC and correlated its significance for patients with HCC. After measuring expression and identifying the location of SOX18 in 153 paired HCC and adjacent non-tumor tissues, we found that SOX18 protein was chiefly expressed in the HCC cell nucleus, but was mainly expressed in normal liver cell cytoplasms. Also, nuclear expression of SOX18 protein was associated with TNM stage (P<0.01) and vascular invasion (P<0.01) of HCC. Furthermore, greater nuclear expression of SOX18 protein indicated shorter 3-year overall and disease-free survival of patients with HCC. Thus, SOX18 may be a prognostic marker for HCC.
Risk Management, Trust and Repeat Online Shopping Intentions: A South African Perspective

E-commerce is a growing phenomenon in Africa. One area of e-commerce that is growing at a very fast rate is online retailing. This is despite concerns that individuals often have in relation to online shopping being associated with more risk than traditional retailing. This chapter looks at practices of online retailers that help in mitigating online shopping risk and the influence of these on customers’ levels of trust as well as on their intentions to re-purchase from specific online stores. The findings show that provision of adequate online product information and online store security has positive influence on customers’ level of trust in an online store. The findings also show that trust in an online store has significant influence on customers’ intentions to repurchase from a store. The findings have wide implications on successful management of online store outlets and these have been highlighted in the chapter.
Does Case Study Research Strategy get along with the Information System (IS)

Does case study research strategy get along with the Information System (IS)? The primary objective of this paper is to answer this question and also bring about awareness on Case Study research strategy which includes challenges, initial developments, current practices, trend and limitations, and key contributors. This paper contributes in providing awareness among researchers especially in Information System domain and also providing fundamental understanding on role of Case Study research usage for nearly two decades in Information System.
Diagnostic patterns in Latino, African American, and European American psychiatric patients.

BACKGROUND The purpose of this study was to examine whether Latino patients presenting for behavioral health treatment showed major systematic differences in presenting symptoms, clinical severity, and psychiatric diagnosis compared with European American and African American patients. Documenting such differences should have important implications for evidence-based clinical practice. METHODS Data were drawn from a large behavioral health service delivery system in New Jersey, and included administrative data, clinical diagnosis, a clinician-rated global level of functioning, and a self-reported symptoms and functioning scale. The study involved a clinical sample of all new admissions into the system between January 1, 2000, and August 31, 2001. To examine the main effects of ethnicity, in the context of other independent variables, logistic regression was performed for each of 3 dependent binary variables: presence or absence of major depression, a schizophrenia spectrum disorder, and bipolar disorder. RESULTS Consistent with previous studies, we found that African Americans were diagnosed as having a disorder in the schizophrenic disorders spectrum more frequently than did Latinos and European Americans (odds ratio, 1.80; 95% confidence interval, 1.62-2.00). Latinos were disproportionately diagnosed as having major depression, despite the fact that significantly higher levels of psychotic symptoms were self-reported by Latinos (odds ratio, 1.74; 95% confidence interval, 1.56-1.93). CONCLUSIONS Latinos in this study were more likely to be clinically diagnosed as having major depression than were other ethnic groups. Further research is needed to determine the reasons for these systematic differences. Possible explanations include (1) self-selection, (2) culturally determined expression of symptoms, (3) difficulties in the accurate application of DSM-IV diagnostic criteria to Latinos, (4) bias related to lack of clinicians' cultural competence, and (5) imprecision inherent in the use of unstructured interviews, possibly combined with clinician bias. Additional research is required to determine the generalizability, accuracy, and applicability of these findings and their possible mechanisms.