Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship between Problematic Facebook Use and Early Maladaptive Schemas

Facebook is an increasingly popular online social media platform for communication, entertainment, and information exchange. Previous studies have shown the relationship between problematic Facebook use (PFU) and mental health problems. Additionally, previous studies have reported associations between maladaptive cognitive schemas and mental health problems. However, little is known about their impact on problematic behavior associated with Facebook use. Consequently, the present study investigated the relationship between PFU and early maladaptive schemas (EMSs) among Facebook users. The study comprised 619 Facebook users (568 females; age range from 18 to 30 years; M = 21.34, SD = 2.41 years). The severity of PFU was assessed using the Facebook Intrusion Scale, and EMS dimensions were assessed using the 90-item Young Schema Questionnaire (YSQ–S3). The findings showed a positive relationship between PFU and EMSs, such as insufficient self-control/self-discipline and approval seeking. PFU was negatively associated with EMSs, such as social isolation/alienation and self-sacrifice schemas. Additionally, the findings showed that EMSs, as well as Facebook use characteristics, such as the time spent using Facebook per week, using Facebook apps, and number of friends on Facebook contributed to explaining the variance in PFU scores. These findings may contribute to a better understanding of mechanisms related to the development of PFU, which are associated with cognitive schemas. Additionally, the results may be useful in developing more effective methods of prevention and treatment of this problematic behavior.
Molecular Dissection of gp130-dependent Pathways in Hepatocytes during Liver Regeneration*

Interleukin-6 (IL-6) via its signal transducer gp130 is an important mediator of liver regeneration involved in protecting from lipopolysaccharide (LPS)-induced liver injury after partial hepatectomy (PH). Here we generated mice either defective (Δ) in hepatocyte-specific gp130-dependent Ras or STAT activation to define their role during liver regeneration. Deletion of gp130-dependent signaling had major impact on acute phase gene (APG) regulation after PH. APG expression was blocked in gp130-ΔSTAT animals, whereas gp130-ΔRas mice showed an enhanced APG response and stronger SOCS3 regulation correlating with delayed hepatocyte proliferation. To define the role of SOCS3 during hepatocyte proliferation, primary hepatocytes were co-stimulated with IL-6 and hepatocyte growth factor. Higher SOCS3 expression in gp130-ΔRas hepatocytes correlated with delayed hepatocyte proliferation. Next, we tested the impact of LPS, mimicking bacterial infection, on liver regeneration. LPS and PH induced SOCS3 and APG in all animal strains and delayed cell cycle progression. Additionally, IL-6/gp130-dependent STAT3 activation in hepatocytes was essential in mediating protection and thus required for maximal proliferation. Unexpectedly, oncostatin M was most strongly induced in gp130-ΔSTAT animals after PH/LPS-induced stress and was associated with hepatocyte proliferation in this strain. In summary, gp130-dependent STAT3 activation and concomitant SOCS3 during liver regeneration is involved in timing of DNA synthesis and protects hepatocyte proliferation during stress conditions.
Stabilizing an amorphous V2O5/carbon nanotube paper electrode with conformal TiO2 coating by atomic layer deposition for lithium ion batteries

Amorphous V2O5 (a-V2O5) thin films were conformally coated onto the surface of hydroxyl (–OH) functionalized multi-walled carbon nanotubes (CNTs) and carbon nanotube (CNT) paper using atomic layer deposition (ALD). In order to achieve 3 Li+ intercalation (442 mA h g−1) and prevent V2O5 dissolution at 1.5 V, a conformal TiO2 protective layer is coated on the surface of V2O5/CNT. A free-standing paper electrode can be made by vacuum filtration or coating pre-fabricated CNT paper directly. The electrochemical characteristics of the TiO2/V2O5/CNT paper electrode were then determined using cyclic voltammetry and galvanostatic charge/discharge curves. Because the TiO2 and V2O5 ALD films were ultrathin, the poor electrical conductivity and low ionic diffusivity of V2O5 did not limit the ability of the V2O5 ALD films to display high specific capacity and high rate capability. A high discharge capacity of ∼400 mA h g−1 is obtained for 15 cycle ALD TiO2 coated 50 cycle ALD V2O5/CNT samples by depositing pre-fabricated CNT paper. We believe that this is the highest capacity for V2O5 cathodes reported in the literature. The capacities of the a-V2O5/CNT nanocomposites are higher than the bulk theoretical values. The extra capacity is attributed to additional interfacial charge storage resulting from the high surface area of the a-V2O5/CNT nanocomposites. These results demonstrate that metal oxide ALD on high surface-area conducting carbon substrates can be used to fabricate high power and high capacity electrode materials for lithium ion batteries. In addition, ultrathin and conformal TiO2 ALD coating can be used to mitigate the dissolution and capacity fading of the cathode.
Possible spin triplet superconductivity in NaxCoO2·yH2O —59Co NMR studies

We report 59Co NMR studies on magnetically oriented powder samples of Co oxide superconductors, NaxCoO2·yH2O, with Tc∼4.7 K. From the two-dimensional powder pattern in the NMR spectrum, the ab-plane Knight shift in the normal state was estimated from the magnetic field dependence of the second-order quadrupole shifts at various temperatures. Below 50 K, the Knight shift shows a Curie–Weiss-like temperature dependence, similarly to the bulk magnetic susceptibility χ. From the analysis of the so-called K–χ plot, the spin and the orbital components of K and the positive hyperfine coupling constant were estimated. The onset temperature of the superconducting transition in the Knight shift does not change much in an applied magnetic field up to 7 T, which is consistent with the reported high upper critical field Hc2. The Knight shift at 7 T shows an invariant behaviour below Tc. No coherence peak just below Tc was observed in the temperature dependence of the nuclear spin–lattice relaxation rate 1/T1 in either case (NMR, nuclear quadrupole resonance). We conclude that the invariant behaviour of the Knight shift below Tc and unconventional behaviours of 1/T1 may indicate spin triplet superconductivity with p- or f-wave symmetry.
6-O-Sulfation of Heparan Sulfate Differentially Regulates Various Fibroblast Growth Factor-dependent Signalings in Culture*

Heparan sulfate (HS) interacts with diverse heparin-binding growth factors and thereby regulates their bioactivities. These interactions depend on the structures characterized by the sulfation pattern and isomer of uronic acid residues. One of the biosynthetic modifications of HS, namely 6-O-sulfation, is catalyzed by three isoforms of HS6-O-sulfotransferase. We generated HS6ST-1- and/or HS6ST-2-deficient mice (6ST1-KO, 6ST2-KO, and double knock-out (dKO)) that exhibited different phenotypes. We examined the effects of HS 6-O-sulfation in heparin-binding growth factor signaling using fibroblasts derived from these mutant mice. Mouse embryonic fibroblasts (MEF) prepared from E14.5 dKO mice produced HS with little 6-O-sulfate, whereas 2-O-sulfation in HS from dKO-MEF (dKO-HS) was increased by 1.9-fold. HS6-O-sulfotransferase activity in the dKO-MEF was hardly detected, and HS2-O-sulfotransferase activity was 1.5-fold higher than that in wild type (WT)-MEFs. The response of dKO-MEFs to fibroblast growth factors (FGFs) was distinct from that of WT-MEFs; in dKO-MEFs, FGF-4- and FGF-2-dependent signalings were reduced to ∼30 and 60% of WT-MEFs, respectively, and FGF-1-dependent signaling was moderately reduced compared with that of WT-MEFs but only at the lower FGF-1 concentrations. Analysis with a surface plasmon resonance biosensor demonstrated that the apparent affinity of dKO-HS for FGF-4 was markedly reduced and was also reduced for FGF-1. In contrast, the affinity of dKO-HS for FGF-2 was 2.5-fold higher than that of HS from WT-MEFs. Thus, 6-O-sulfate in HS may regulate the signalings of some of HB-GFs, including FGFs, by inducing different interactions between ligands and their receptors.
Prognostic and Predictive Value of Circulating and Disseminated Tumor Cells in Breast Cancer: A National Cancer Database (NCDB) Analysis

Importance: Our understanding of the utility of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) as clinical biomarkers continues to evolve. Objective: This study evaluated (1) clinicopathologic factors associated with the presence of CTCs or DTCs, (2) the prognostic value of CTCs or DTCs by disease stage, 3), the value of these biomarkers in predicting the benefit of chemotherapy. Design: This is a retrospective analysis of patients with breast cancer (BC) diagnosed between 2004 and 2016 using the National Cancer Database (NCDB). To evaluate variables associated with the presence of CTCs or DTCs at the univariate level, we used chi-squared and Wilcoxon rank-sum tests. Multivariate logistic regression models were then constructed using significant variables. Consequently, we included CTC or DTC status (i.e. positive or negative) in multivariate, stage-by-stage Cox regression analyses for overall survival (OS). After stratifying by receptor status and staging, we used the Kaplan-Meier method to explore chemotherapy efficacy in CTC- or DTC-positive vs. CTC- or DTC-negative subsets. Results: Factors significantly associated with CTCs were race, progesterone receptor status, HER2 status, histology and AJCC N- and M-staging. Factors associated with DTCs were race, HER2 status, histology and AJCC N-staging. CTCs were associated with poor OS in late-stage (III and IV) but not early-stage (0-II) BC. DTCs were not significantly associated with OS in either context. In hormone receptor (HR)-positive disease, chemotherapy was associated with better OS when CTC status was positive, both in early-stage and late-stage disease. In a subset of patients without CTCs, however, chemotherapy conferred no survival benefit. DTC status was not a significant predictor of chemotherapy efficacy in early or late-stage, HR+ disease. Conclusions: This study suggests that CTC-status is a significant prognostic factor at later stages of BC; yet it can also help guide management of early-stage disease as it appears predictive for chemotherapy benefit.
Optical studies of ZnO grown by metalorganic chemical vapour deposition

The controlled n-type and p-type doping of ZnO is an ongoing and challenging field of study which needs to be resolved before this material can fulfill its great promise as an optoelectronic material. Metalorganic chemical vapour deposition (MOCVD) is a process that has been extensively investigated for ZnO growth. However, there have been very few reports of high resolution photoluminescence (PL) spectroscopy for MOCVD grown ZnO. In this thesis, strong donor bound exciton transitions with linewidths as low as 0.2 meV were observed in a 4.2 K low temperature PL spectrum of nominally undoped ZnO epilayers grown with dimethylzinc (DMZn) and nitrous oxide (N2O) at 800 ◦C on c-plane sapphire substrates by MOCVD. Intentional n-type doping of ZnO by MOCVD with group III dopants such as In and Al at high growth temperature has been studied. The addition of controlled amounts of In and Al precursors allows us to unambiguously observe donor bound exciton emission from these impurities which results in identification of the dominant residual donor in nominally undoped ZnO to be Ga and to infer the residual compressive strain in the layers due to lattice mismatch between ZnO and the sapphire substrate. PL measurements on ZnO epilayers annealed in oxygen at 900−1000 ◦C show that group III dopants are quite mobile at temperatures above 800 ◦C. Raman scattering spectroscopy measurements were performed to investigate the vibrational properties of MOCVD grown ZnO. Strong and broad vibrational modes due to sp2 graphitic carbon clusters were found in the Raman spectrum of low growth temperature ZnO epilayers at around 1350 cm−1 and 1600 cm−1. At high growth temperatures (>700 ◦C), the graphitic modes disappear and the spectrum is dominated by ZnO lattice phonons.
Rotational Raman scattering in the Earth's atmosphere

An accurate description of multiple scattering is essential in atmospheric radiative transfer modeling of ultraviolet and visible light in the Earth’s atmosphere. Part of this multiply scattered radiation is inelastically scattered due to rotational Raman scattering by air. The distribution of the inelastically scattered light leads to filling-in of Fraunhofer lines, and to filling-in of absorption features of atmospheric constituents. This complicates the interpretation of satellite measurements of backscattered sunlight. Several atmospheric radiative transfer models consider multiple elastic scattering, but allow only one order of inelastic Raman scattering. In this paper, we investigate the validity of this approximation by taking also multiple inelastic scattering into account. We present an extension of the doubling-adding method which for the first time accounts for both multiple elastic and multiple inelastic scattering of light. Numerical implementation of this method shows that, in simulations of reflected light by a model atmosphere, multiple inelastic scattering contributes about 0.5% to the total intensity around 325 nm and about 0.2% around 395 nm. At the center of the Fraunhofer lines and in the Huggins ozone absorption bands this contribution is generally larger. For a simulated measurement by a typical space-borne spectrometer with 0.2 nm instrumental resolution, the observed contribution is about 0.6% at the Ca II K and H lines, located at 393.48 nm and 396.97 nm respectively. At the 325 nm Huggins ozone absorption feature this contribution due to multiple inelastic scattering is also about 0.6%.
Effects of photobiomodulation on auriculotherapy points for sleep disorders, anxiety, and temporomandibular dysfunctions

ABSTRACT Objective The purpose of this study was to evaluatephotobiomodulation applied at auriculotherapy points forsleep disorder (SD) and anxiety related to temporomandibulardysfunction (TMD). Methods The study consisted of two groups of 20 participants: Auriculotherapy group (A) and Control Group(C). The participants responded to the RDC/TMD, Fletcher & Luckett questionnaires, and the Beck Anxiety Inventory to analyze TMD, SD, and anxiety before and after the treatment. Results The participants presented scores corresponding to mild to moderateanxiety (MDN = 17; CI = [13.16;22.31]) and after treatment, normalor non-existent anxiety (MDN = 9; CI = [8.76; 17.12]) (p = 0.005). There was no significant difference (p > 0.05) between the controland 20 auriculotherapy groups for TMD and SD. Discussion The results suggest that auriculotherapy was effective in the treatment of anxiety. However, it did not prove effective with the results of the SD and symptoms of TMD.
Endoglin: An ‘Accessory’ Receptor Regulating Blood Cell Development and Inflammation

Transforming growth factor-β1 (TGF-β1) is a pleiotropic factor sensed by most cells. It regulates a broad spectrum of cellular responses including hematopoiesis. In order to process TGF-β1-responses in time and space in an appropriate manner, there is a tight regulation of its signaling at diverse steps. The downstream signaling is mediated by type I and type II receptors and modulated by the ‘accessory’ receptor Endoglin also termed cluster of differentiation 105 (CD105). Endoglin was initially identified on pre-B leukemia cells but has received most attention due to its high expression on activated endothelial cells. In turn, Endoglin has been figured out as the causative factor for diseases associated with vascular dysfunction like hereditary hemorrhagic telangiectasia-1 (HHT-1), pre-eclampsia, and intrauterine growth restriction (IUPR). Because HHT patients often show signs of inflammation at vascular lesions, and loss of Endoglin in the myeloid lineage leads to spontaneous inflammation, it is speculated that Endoglin impacts inflammatory processes. In line, Endoglin is expressed on progenitor/precursor cells during hematopoiesis as well as on mature, differentiated cells of the innate and adaptive immune system. However, so far only pro-monocytes and macrophages have been in the focus of research, although Endoglin has been identified in many other immune system cell subsets. These findings imply a functional role of Endoglin in the maturation and function of immune cells. Aside the functional relevance of Endoglin in endothelial cells, CD105 is differentially expressed during hematopoiesis, arguing for a role of this receptor in the development of individual cell lineages. In addition, Endoglin expression is present on mature immune cells of the innate (i.e., macrophages and mast cells) and the adaptive (i.e., T-cells) immune system, further suggesting Endoglin as a factor that shapes immune responses. In this review, we summarize current knowledge on Endoglin expression and function in hematopoietic precursors and mature hematopoietic cells of different lineages.
Anxious and Angry: A Replication Investigating the Effects of Emotions on Perceptions of Online Review Helpfulness

This study is an exact replication of three studies investigating how emotional content embedded in a product review influences perceptions of review helpfulness (Yin, Bond, and Zhang 2014). The replication confirms that emotional content influences perceptions of review helpfulness. Consistent with the original study, our experimental findings indicate that the relationship between review helpfulness and the emotion embedded in a review is mediated by the perception of reviewer cognitive effort. However, this experiment found that angry as well as anxious reviews were considered helpful, deviating from the original findings in which only anxious reviews were perceived as helpful. Further, examination of a large sample of reviews confirms that reviews with anxious content are rated as more helpful, while angry content does not influence helpfulness. However, we were unable to replicate the findings of the second experiment reported in the original research as neither anxious nor angry reviews were considered helpful in our second study. It may be that, at this time, reviews with high levels of emotional content are not perceived as helpful. Instead, we found that only empathy (perceptions of shared emotion with the reviewer) impacted perceptions of review helpfulness. Therefore, the influence of empathy on review helpfulness may be worth investigating in future studies. That our findings deviate slightly from those of the original study provides further support for the importance of replications.
MRE11 Is Crucial for Malaria Parasite Transmission and Its Absence Affects Expression of Interconnected Networks of Key Genes Essential for Life

The meiotic recombination 11 protein (MRE11) plays a key role in DNA damage response and maintenance of genome stability. However, little is known about its function during development of the malaria parasite Plasmodium. Here, we present a functional, ultrastructural and transcriptomic analysis of Plasmodium parasites lacking MRE11 during its life cycle in both mammalian and mosquito vector hosts. Genetic disruption of Plasmodium berghei mre11 (PbMRE11) results in significant retardation of oocyst development in the mosquito midgut associated with cytoplasmic and nuclear degeneration, along with concomitant ablation of sporogony and subsequent parasite transmission. Further, absence of PbMRE11 results in significant transcriptional downregulation of genes involved in key interconnected biological processes that are fundamental to all eukaryotic life including ribonucleoprotein biogenesis, spliceosome function and iron–sulfur cluster assembly. Overall, our study provides a comprehensive functional analysis of MRE11′s role in Plasmodium development during the mosquito stages and offers a potential target for therapeutic intervention during malaria parasite transmission.
Text generation using Monte-Carlo Sampling Anonymous ACL submission

Recurrent Neural Networks are one of the main generative models that have been trained to produce various sequences of words. However, this training process contains maximizing likelihood function conditioned on current hidden state and the previously seen tokens, the results are not convincing. Variational Auto Encoders and adverserial training models are another group of methods for text generation that try to generate appropriate sentences from scratch. Generating suitable sentences from scratch still is an open problem. In this paper, we propose a new generative model by applying Monte-Carlo sampling as a basic step on the candidate sentences derived from paraphrase replacement. The method selects an existing sentence from the corpus as
The Pharmacological Approach to Oncologic Patients with Acute Coronary Syndrome

Among acute coronary syndrome (ACS) patients, 15% have concomitant cancer, especially in the first 6 months after their diagnosis, as well as in advanced metastatic stages. Lung, gastric, and pancreatic cancers are the most frequent malignancies associated with ACS. Chemotherapy and radiotherapy exert prothrombotic, vasospastic, and proinflammatory actions. The management of cancer patients with ACS is quite challenging: percutaneous revascularization is often underused, and antiplatelet and anticoagulant pharmacological therapy should be individually tailored to the thrombotic risk and to the bleeding complications. Sometimes oncological patients also show different degrees of thrombocytopenia, which further complicates the pharmacological strategies. The aim of this review is to summarize the current evidence regarding the treatment of ACS in cancer patients and to suggest the optimal management and therapy to reduce the risk of adverse coronary events after ACS in this high-risk population.
HDL Proteome and Alzheimer’s Disease: Evidence of a Link

Several lines of epidemiological evidence link increased levels of high-density lipoprotein-cholesterol (HDL-C) with lower risk of Alzheimer’s disease (AD). This observed relationship might reflect the beneficial effects of HDL on the cardiovascular system, likely due to the implication of vascular dysregulation in AD development. The atheroprotective properties of this lipoprotein are mostly due to its proteome. In particular, apolipoprotein (Apo) A-I, E, and J and the antioxidant accessory protein paraoxonase 1 (PON1), are the main determinants of the biological function of HDL. Intriguingly, these HDL constituent proteins are also present in the brain, either from in situ expression, or derived from the periphery. Growing preclinical evidence suggests that these HDL proteins may prevent the aberrant changes in the brain that characterize AD pathogenesis. In the present review, we summarize and critically examine the current state of knowledge on the role of these atheroprotective HDL-associated proteins in AD pathogenesis and physiopathology.
Linear and nonlinear relationship of wheat storage characteristics

Linear and nonlinear relationship of wheat storage characteristics Kiurchev Sergey*, Verholantseva Valentina Tavria State Agrotechnological University, Melitopol, Ukraine * Corresponding author at: Tavria State Agrotechnological University 18 B. Khmelnistskiy Avenue, Melitopol, Ukraine, 72310. Tel. : +38 0978285043 E-mail addresses: dec.tgatu@mail.ru (S. Kiurchev), milaeva.v@mail.ru (V. Verholantseva) Article history: Received 20 April 2015 Received in revised form 30 April 2015 Accepted 6 May 2015