Miracle-dz/UniFAR-FTUs huggingface dataset:
The beer and biofuels laboratory: A report on implementing and supporting a large, interdisciplinary, yeast‐focused course‐based undergraduate research experience

Course‐integrated Undergraduate Research Experiences (CUREs) involve large numbers of students in real research. We describe a late‐year microbiology CURE in which students use yeast to address a research question around beer brewing or synthesizing biofuel; the interdisciplinary student‐designed project incorporates genetics, bioinformatics, biochemistry, analytical chemistry, and microbiology. Students perceived significant learning gains around multiple technical and “becoming a scientist” aspects of the project. The project is demanding for both the students and the academic implementers. We examine the rich landscape of support and interaction that this CURE both encourages and requires while also considering how we can support the exercise better and more sustainably. The findings from this study provide a picture of a CURE implementation that has begun to reach the limits of both the students' and the academics' capacities to complete it. © 2018 by The International Union of Biochemistry and Molecular Biology, 46(3):213–222, 2018.
Impact of Medication Adherence on Hospitalization Risk and Healthcare Cost

Objective:The objective of this study was to evaluate the impact of medication adherence on healthcare utilization and cost for 4 chronic conditions that are major drivers of drug spending: diabetes, hypertension, hypercholesterolemia, and congestive heart failure. Research Design:The authors conducted a retrospective cohort observation of patients who were continuously enrolled in medical and prescription benefit plans from June 1997 through May 1999. Patients were identified for disease-specific analysis based on claims for outpatient, emergency room, or inpatient services during the first 12 months of the study. Using an integrated analysis of administrative claims data, medical and drug utilization were measured during the 12-month period after patient identification. Medication adherence was defined by days’ supply of maintenance medications for each condition. Patients:The study consisted of a population-based sample of 137,277 patients under age 65. Measures:Disease-related and all-cause medical costs, drug costs, and hospitalization risk were measured. Using regression analysis, these measures were modeled at varying levels of medication adherence. Results:For diabetes and hypercholesterolemia, a high level of medication adherence was associated with lower disease-related medical costs. For these conditions, higher medication costs were more than offset by medical cost reductions, producing a net reduction in overall healthcare costs. For diabetes, hypercholesterolemia, and hypertension, cost offsets were observed for all-cause medical costs at high levels of medication adherence. For all 4 conditions, hospitalization rates were significantly lower for patients with high medication adherence. Conclusions:For some chronic conditions, increased drug utilization can provide a net economic return when it is driven by improved adherence with guidelines-based therapy.
Pediatric asthma deaths in Victoria: The mild are at risk

Previous reviews of pediatric asthma mortality have mostly been from hospital‐based clinic populations and suggest that only those with severe asthma are most at risk. This report summarizes an investigation, by interviewer‐administered questionnaire, into the circumstances surrounding the death in all patients aged 20 years or less who died from asthma in the State of Victoria over a 3 year period from May 1, 1986. © 1992 Wiley‐Liss, Inc.
The ethics of the brand

Ethical brands have risen to prominence in recent years as a market solution to a diverse range of political, social and, in this case most interestingly, ethical problems. By signifying the ethical beliefs of the firm behind them, ethical brands offer an apparently simple solution to ethical consumers: buy into the brands that represent the value systems that they believe in and avoid buying into those with value-systems that they do not believe in. Lehner and Halliday (this issue), for example, argue that brands are a ‘practical and effective way’ (13) to address the market demand for ethicality because ‘they offer a means for firms to internalise positive externalities’ (23) associated with ethical behaviour. The assumption, then, is that if society desires ethical behaviour from firms, firms will not dare to behave otherwise for fear of inflicting costly damage on their carefully crafted brand images. According to economic rules of demand and supply, the market should then ensure that firms respond to the ethical requirements of the society in which they reside. As a consequence, brand management has incorporated as one of its main tasks the translation of the ethical positions on the market into communicable brand messages. However, critical research has acknowledged the fundamental incompatibility of ethics and capitalism, as it is argued that ‘ethics’ tend to be used quite superficially as a legitimising signpost, effectively concealing the (possible) structural lack of ethics built into the capitalist order per se. Consequently, ethical branding may in fact legitimise the un-ethical aspects and elements of capitalist relations and practices. Moreover, when ethics are commodified, e.g. in the form of brand image, the human relations underlying the production processes are, in effect, concealed rather than exposed: ‘instead of seeing these human relations we see only an object’ (Jones, Parker and ten Bos, 2005: 104).
Analysis for Sales Revenue and Economic Index: CPI with Business Statistics Methods

This report is focus on different descriptive and inferential statistical methods and analytical tools by analyzing a public company named Blackmores Limited (ASX: BKL) listed on the Australian Stock Exchange. Firstly, Sales Revenue in Blackmores Limited and macroeconomic variable CPI are compared with statistical methods including two correlation coefficients. Furthermore, prediction data for 2016 and 2017 are also included. In addition, prediction Sales Revenue for 2016 and 2017 is also existed by using semi-average method and least squares method. Finally, this report will evaluate all measuring and prediction methods. Introduction Business statistics is used for analyzing reliable data on the basis of accurate investigation and research, and sorts out correct principles and methods for managers to make correct decisions under uncertain conditions [1]. In general, by comparing with the macroeconomic data, a ‘smart’ company can seize market opportunities quickly and adjust its market strategy in order to maximize its sales and profits. Blackmores Limited Company, as a representative healthcare company, precisely use correct business statistical methods to adapt market situation which will always be the leading position in the health-care industry [2]. Company Profile Blackmores Limited is chosen as the researching company in this thesis because of its reputation and status in health-care industry especially its positive correlation with CPI (Consumer Price Index). In general, Blackmores Limited (ASX: BKL) is the leading natural health-care company across the Asia Pacific region. Blackmores limited has explicit company location in three aspects from product, brand and enterprise. Firstly, Blackmores Limited focuses on natural health-care medical product with highest quality ingredients including high-quality vitamins, minerals, herbs and supplements. Secondly, the brand for Blackmores Limited is quite popular among Australia and Asia, furthermore, it is particularly noteworthy that it accounts for 56% of the health-care market in Australia [3]. As for development prospect of this enterprise, Blackmores limited focuses on four key strategic priorities—consumer centricity, Asia growth, product leadership and operational effectiveness to enhance enterprise’s brand popularity. Data Analysis Using Business Statistics Model Because of abundant financial background, most shareholders choose BKL (Blackmores Limited) as their first choice to invest. By the end of 2017, Blackmores Limited has an annual increase in sales which is up to $549,243,000. Overall, there are reasons to believe that Blackmores Limited has a bright development prospect in both Australia and China.
Evaluation of tumor aggressiveness in breast carcinoma according to a scoring method

A scoring system was used to classify 310 patients with breast carcinoma. Tumors were divided and scored according to their architectural patterns and histological features of known prognostic significance such as tumor volume, nuclear grade, mitosis, etc. According to the scoring value, tumors were classified as aggressive (A), moderately aggressive (M), and low aggressive (L). Results showed a higher rate of metastasis in patients with A tumors (72%) and M tumors (63%) when compared with L tumors (22%). There were 175 patients with axillary lymph node metastasis. Of these, 101 had A tumors, 91 had recurrences (90%), and 81 died (80%); of the 56 patients with M tumors, 26 had recurrences (46%) and 9 died (16%) (P < 0.001). None of the 18 cases classified as L recurred (P < 0.001). There were 135 patients with no nodal metastasis: 39 had A tumors (21 recurrences [54%] and 19 deaths [49%]) and 96 had M and L tumors (1 recurrence [1%] and no deaths) (P < 0.001).
Limited taste discrimination in Drosophila

In the gustatory systems of mammals and flies, different populations of sensory cells recognize different taste modalities, such that there are cells that respond selectively to sugars and others to bitter compounds. This organization readily allows animals to distinguish compounds of different modalities but may limit the ability to distinguish compounds within one taste modality. Here, we developed a behavioral paradigm in Drosophila melanogaster to evaluate directly the tastes that a fly distinguishes. These studies reveal that flies do not discriminate among different sugars, or among different bitter compounds, based on chemical identity. Instead, flies show a limited ability to distinguish compounds within a modality based on intensity or palatability. Taste associative learning, similar to olfactory learning, requires the mushroom bodies, suggesting fundamental similarities in brain mechanisms underlying behavioral plasticity. Overall, these studies provide insight into the discriminative capacity of the Drosophila gustatory system and the modulation of taste behavior.
Tratamiento de la implicación textual a través de patrones semánticos

Resumen. En el presente trabajo se presenta una nueva metodologia para el Problema de Implicacion Textual. Esta metodologia propone el empate de patrones sintacticos, los cuales estan construidos por la cantidad de terminos. Esta aproximacion es una variante del modelo de aproximacion por empatamiento. Esta metodologia fue probada y validada con tres corpus ofrecidos por varias conferencias internacionales (RTE1, CLTE y SICK). Los resultados obtenidos son comparables con los mejores resultados internacionales.
2-Deoxy-D-glucose protects retinal ganglion cells against excitotoxicity

Caloric restriction mimicked by administration of 2-deoxy-D-glucose (2DG) has been shown to protect cerebral neurons against ischemia and excitotoxicity. This study examined the protective effects of pretreatment with 2DG on retinal neurons in N-methyl-D-aspartate (NMDA) excitotoxicity in rats. There was a significantly reduced number of TUNEL-labeled cells in the retinal ganglion cell layer 18 h after intravitreal injection of NMDA with 2DG pretreatment. At 7 days after NMDA, 2DG pretreatment significantly preserved neurons in the retinal ganglion cell layer and reduced immunoreactivity of glial fibrillary acidic proteins in retinas. Our findings demonstrate that caloric restriction mimicked by 2DG protects retinas from NMDA excitotoxicity.
Phonon-coupling enhanced absorption of alloyed amorphous silicon for solar photovoltaics

Using the observed temperature dependence of a-Si:H photon absorption spectrum and the weak-phonon interaction second-order transition theory, phonon-coupling enhanced photon absorption is predicted for a-Si-Ge and a-Si-Sn alloys. The ab initio calculated electron and phonon properties of the alloyed amorphous phase show minimally altered electronic states and significant redshifted phonon energies. This phonon shift enhances the optical phonon-coupled photon absorption resulting in increased current generation near the optical band edge. We find that this enhancement favors low-energy optical-phonon modes, thus making the soft-bond forming Sn the choice alloying element.
Modélisation causale en vue de la commande d'un translateur piézoélectrique plan pour une application haptique

Pour rendre compte physiquement de la manipulation d'un objet virtuel dans l'espace ou sur un plan, la plupart des dispositifs haptiques actuels font appel a des actionneurs a un seul degre de liberte, dont les actions sont couplees par diverses liaisons mecaniques (type pantographe). La technologie piezoelectrique est une solution avantageuse dans ce domaine d'utilisation, pour son important effort massique, le travail a faible vitesse, et surtout la capacite a motoriser plusieurs degres de liberte a partir d'un seul actionneur. Pour cette raison, un translateur piezoelectrique plan a onde stationnaire est etudie. Un modele simplifie est elabore pour offrir une interpretation globale des phenomenes de contact. Il est etabli selon le formalisme du graphe informationnel causal qui met en evidence deux asservissements applicables au domaine haptique : un retour d'effort actif par le controle en force, et une solution alternative comparable a un embrayage, qualifie de retour d'effort dissipatif.
Gibber: Live coding audio in the Browser

We present Gibber: a live coding environment for web browsers. Gibber performances are written in pure JavaScript with no syntactical additions or modifications; this enables Gibber code to be executed in any web page viewed inside a browser implementing a realtime audio API. Gibber offers an array of synthesis options (FM, granular, subtractive, physical modeling), audio effects and sequencing objects to control them. The Gibber environment enables simple networked performances where multiple users simultaneously control a remote instance of Gibber. We strove to make the syntax of Gibber clear and concise; when coupled with the ability to run examples in any web page this gives Gibber interesting possibilities as an educational tool.
Belt and Road: The China Dream?

China is committed to a very ambitious infrastructure development project, referred to as the ‘Belt and Road Initiative’. This involves the implementation of massive infrastructure investments that, among other things, will reduce transportation costs. This paper employs a structural gravity approach to analyze how the reduction in transportation costs between China and the EU would change trade flows and consumer welfare in China, EU and the rest of the World. We also look at how these welfare improvements compare to the gains from signing shallow and deep free trade agreements with the EU, as well as analyzing how the BRI interplays with the US-led mega trade deals: TTIP and TPP. Our results indicate substantial gains from the BRI for China and the EU. A 30 percent reduction in transportation costs between China and the EU would increase the welfare of a representative consumer in China by 1.51 percent and the EU by 0.97 percent. Combining the BRI with a deep FTA would increase welfare by 4.90 and 2.94 percent respectively. Furthermore, the potential negative effect of the TPP on China is more than compensated by the BRI initiative.
Security and Privacy Challenges in Content-Centric Networks

Author(s): Wood, Christopher Alphonse | Advisor(s): Tsudik, Gene | Abstract: Today's Internet is aging. Connections are point-to-point and increasinglyprotected by end-to-end encryption. This reduces security to data transportinstead of data itself. Content-Centric Networking (CCN) is a paradigmshift away from this host- and channel-based design. CCN is anarchitecture for naming, securing, and transferring named data fromproducers to consumers upon request.Consumers issue interests for named content. Routers forward interests towardsproducers capable of providing authentic content with cryptographicname-to-data bindings. Once found, routers forward content, in reverse,towards consumers. Routers may also choose to cache content to serve duplicatefuture interests. Object security, native authenticity, pull-based datatransfer, flow symmetry, and in-network services are among the notablecharacteristics of CCN. In this dissertation, we study security and privacyissues that stem from these architectural properties. Specifically, we studyvariations and facets of access control, privacy risks and remedies, andnetwork-layer availability attacks and architectural mitigations. For each issue,we describe the problem in detail and explain several countermeasures. We also presentdetailed analyses and experimental assessments for each approach. We find thatsound engineering can mitigate several issues, while others remain insurmountablechallenges exacerbated by fundamental security and performance tradeoffs made by CCN.
A Novel Curriculum to Optimize Emergency Medicine Residents’ Exposure to Pediatrics

Recognizing the profound impact that emergency medicine residency graduates have on the quality of the emergency care of children, residency training programs must provide a broad clinical experience and training in pediatric care. Traditionally, part of this training has included a hospital ward rotation in inpatient pediatrics. However, these experiences may be perceived by learners as being educationally low-yield in terms of direct applicability to the practice of emergency medicine. This educational innovation describes the development of a novel curriculum for teaching pediatrics to emergency medicine residents. Rather than focusing on tasks disconnected from emergency medicine practice, residents provide the initial clinical care for patients in the emergency department in a professional setting situated to mirror their ultimate professional practice. The innovation involves longitudinal patient follow-up, with mentored supervision and discussion to reinforce learning. The curriculum includes dedicated Pediatric ED time, deliberate inpatient and phone follow-up, ward rounds, focused pediatric topics, and direct observation assessment and feedback on pediatric clinical skills. This novel curriculum emphasizes the importance of situated learning, and is one component of a longitudinal teaching plan for pediatrics within an emergency medicine residency.
The impact of social media platform selection on effectively communicating about corporate social responsibility

ABSTRACT Given the limited amount of research conducted to date on the content and effectiveness of social media-based CSR communication, this study has two core objectives. First, it explores which social media platforms (Facebook, LinkedIn, Pinterest, Twitter and YouTube) leading companies use to communicate about CSR activities and the impact of this selection on brand equity. Second, this study further explores how brand equity is impacted by firms’ communications about specific types of CSR activities (environment, community, employee and customer) on differing social media platforms. The results suggest that leading organizations whom are crafting social media-based CSR campaigns in ways that link relevant content, social media platform and stakeholder interests have higher levels of brand equity. Further, the results suggest there are many untapped opportunities organizations have yet to take advantage of in terms of content and social media platforms used for CSR communications. This study provides a groundwork for future research on communicating specific dimensions of CSR activity, the best platform(s) for communicating these dimensions and the examination of how best to engage stakeholders through the interactive nature of social media resources.
Managing the Planning and Development of Authentic Eco-Cultural Tourism in Kazakhstan

ABSTRACT With the increasing visitors’ attention to the authenticity of heritage and tourism practices when they visit off the beaten track destinations, the question of authenticity in the experience of place becomes significant for the stakeholders involved in the management and development of tourism. This study investigates the managerial practices associated with the planning and development of authentic eco-cultural tourism in Kazakhstan. A qualitative case study research approach based on semi-structured interviews with policymakers, tourism developers and community members from two eco-tours in South and Central Kazakhstan is adopted to examine stakeholders’ authentication positions on various topic areas and eco-cultural tourism practices. Four key managerial and planning implications related to stakeholders’ perceptions of authenticity of Kazakhstani eco-cultural tourism are identified: empowering local communities for tourism development, redefining the host–guest tourism experience, certifying and labelling eco-cultural heritage sites and including authenticity as a unique and important feature in future tourism products and experiences.
Relation between Substrate Specificity and Domain Structure of 92‐kDa Type IV Collagenase a

The 92-kDa type IV collagenase (MMP-9) is a member of the matrix metalloproteinase (MMP) family that degrades gelatin, types IV, V, and XI collagen. MMP-9, similar to the other member of the MMP contains a central catalytic domain homologous to the zinc-binding domain of thermolysin.4 This putative active site is flanked by an amino-terminal domain important in the conversion from the latent to the active form of the enzyme and by a highly variable carboxy-terminal domain with some homology to hemopexin. MMP-9 has two additional domains, one with homology to the gelatin-binding region of fibronectin and the other with a collagen-like sequence. 'X2 Thus, it is logical to assume that properties that are unique to a given metalloproteinase are determined by peptide sequences in variable regions of the proteins. Collier and co-workers5 demonstrated that the fibronectin-like gelatin-binding domain of MMP-9 is essential for the binding of gelatin; therefore, it is tempting to speculate if the type V collagen-like domain is involved in interaction of the enzyme with the collagen substrates (types IV, V, and XI). It is also possible that degradation of gelatin and native collagen substrates may be unrelated to these domains. Here we show that the fibronectin-like gelatin-binding domain not only is important for binding of MMP-9 to gelatin substrate, but also is essential for gelatinolytic activity of the enzyme. Contrary to expectation, collagenolytic activity (types IV, V, and XI) of the enzyme is independent of type V collagen-like binding domain.
Output to input saturation transformation: Demonstration and application to disturbed linear systems

In the case of linear systems, control law design is often performed so that the resulting closed-loop meets specific frequency requirements. However, in many cases, it may be observed that the obtained controller does not enforce time-domain requirements amongst which the objective of keeping an output variable in a given interval. In this article, a transformation is proposed to convert expected bounds on an output variable into time-varying saturations on the synthesized linear control law. It is demonstrated that the resulting closed-loop is stable and satisfies time-domain constraints in the presence of unknown bounded disturbance. An application to a linear ball and beam model is presented.