Miracle-dz/UniFAR-FTUs huggingface dataset:
ETUDE DES MECANISMES DE REGULATION DE LA SECRETION ET DE L'EXPRESSION DES MUCINES GASTROINTESTINALES PAR LA LEPTINE

Les mucines sont les molecules structurales de base du gel de mucus qui assure la protection et la lubrification de la muqueuse gastro-intestinale. Notre but etait de determiner l'effet de la leptine sur la secretion et l'expression des mucines gastro-intestinales. Cette etude a ete realisee in vivo chez le rat et in vitro a l'aide des lignees cellulaires de rat DHE et humaine HT29-MTX. Nous avons trouve que ces 2 lignees expriment les recepteurs (Ob-R) de la leptine. La perfusion luminale de la leptine dans le colon de rat ainsi que la stimulation des cellules DHE par la leptine a entraine une augmentation de la secretion de mucines et du niveau des ARNm codant pour rMuc2, rMuc3 et rMuc4. Cet effet de la leptine etait dose dependant. Testee dans les HT29-MTX, la leptine a provoque une augmentation de la secretion de mucines ainsi qu'une augmentation des transcrits de MUC2, MUC4 et MUC5AC via la voie de la PKC, la PI3K et les MAPK. Ces resultats montrent que la leptine pourrait jouer un role essentiel dans la protection de la muqueuse colique.
Agent-Based Social Networks

Social networking sites have deeply changed the face of the web in the last decade. Social web sites have attracted users with very weak interest in technology, including people that before the social networking revolution were not even regular users of other popular Internet services and computers in general (Stroud, 2008). The phenomenon is so widespread that many people started using social networking systems to ask questions directly to people instead of querying search engines (Morris et al., 2010) and in place of regular email. Moreover, some of the largest social networking sites constitute a separate and closed network (Sabbag, 2011). After the huge success of the early social networking systems, many other players came in the social networking market and nowadays hundreds of different social networking systems exist. Even if the social networking systems are greatly dissimilar in their user base and functionality, they are almost always centralized systems. The centralized nature allows a simple browser-based user experience and, moreover, many algorithms, e.g., friend suggestion, are far easier and more efficient to implement in this setting. However, such a solution has many drawbacks, e.g., lack of privacy, lack of anonymity, risks of censorship and operating costs. Therefore, a decentralized architecture may offer several advantages, but it may involve some security and design issues that are not present in traditional social networks. This chapter has the goal of introducing social networks and how they can take advantages of a decentralized architecture and how the use of multi agent technologies help to cope with its security and design issues and, in addition, to support the creation of innovative services for its users.
Comparison of the Outcomes Between Open and Minimally Invasive Esophagectomy

Objective:We report patient outcomes from esophageal resection with respect to morbidity and cancer survival comparing open thoracotomy and laparotomy (Open), with a thoracoscopic/laparotomy approach (Thoracoscopic-Assisted) and a total thoracoscopic/laparoscopic approach (Total MIE). Methods:From a prospective database of all patients managed with cancer of the esophagus or esophagogastric junction, patients who had a resection using one of three techniques were analyzed to assess postoperative variables, adequacy of cancer clearance, and survival. Results:The number of patients for each procedure was as follows: Open, 114; Thoracoscopic-Assisted, 309; and Total MIE, 23. The groups were comparable with respect to preoperative variables. The differences in the postoperative variables were: less median blood loss in the Thoracoscopic-Assisted (400 mL) and Total MIE (300 mL) groups versus Open (600 mL); longer time for Total MIE (330 minutes) versus Thoracoscopic-Assisted (285 minutes) and Open (300 minutes); longer median time in hospital for Open (14 days) versus Thoracoscopic-Assisted (13 days), Total MIE (11 days) and less stricture formation in the Open (6.1%) versus Thoracoscopic-Assisted (21.6%), Total MIE (36%). There were no differences in lymph node retrieval for each of the approaches. Open had more stage III patients (65.8%) versus Thoracoscopic-Assisted (34.4%), Total MIE (52.1%). There was no difference in survival when the groups were compared stage for stage for overall median or 3-year survival. Conclusion:Minimally invasive techniques to resect the esophagus in patients with cancer were confirmed to be safe and comparable to an open approach with respect to postoperative recovery and cancer survival.
Urine Creatinine Excretion: Variability and Volume Dependency During Sleep Deprivation

&NA; Continuous 6‐hour urine samples were collected from 4 healthy young adult men during 4 control days and 9 days of sleep deprivation. Considerable variation in creatinine levels was present in the samples from all 4 subjects, and there was a significant diurnal pattern during the control period. This diurnal pattern, however, was undetectable during sleep deprivation. Urine volume correlated very highly with creatinine in all subjects, and it appears that creatinine excretion was a volume‐dependent phenomenon. A more even fluid intake and urine volume throughout the day and night during the 205 hours of sleeplessness may have accounted for the disappearance of the diurnal creatinine pattern during this period.
SDRE control of single phase PWM inverter using FPGA based hardware controller

A new control method based on State-Dependent Ricatti Equation (SDRE) for single phase PWM inverter with FPGA based hardware controller is proposed. Deadbeat control is well known with the quick transient response and accuracy, but the robustness for the variation of the system parameter is the key issue. In the SDRE approach, the nonlinear system is assumed as a frozen-in-time linear time varying system, the state conditions which include parameter variations were reflected to the feedback system. In the case of power electronics applications, a fast calculation capability of the controller is required. In this paper, SDRE control is designed for single phase PWM inverter using FPGA based hardware controller. And SDRE control is compared with the conventional deadbeat control in the point of view from the robustness for the variation of the system parameter. Through simulations and experiments, the proposed method was verified.
Information Asymmetry and Acquisition Premiums in Domestic and Cross Border M&As in Emerging Markets

In this paper, we test and find a strong positive relationship between information asymmetry and acquisition premium in the acquisitions of emerging market firms. The results are based on a large sample of domestic and cross-border acquisitions in 20 emerging countries between 1990 and 2007. We also confirm that under higher level of information asymmetry, acquiring firms tend to use lower cash payments (i.e., higher stock payments) and they are more likely to acquire majority control (>50%) in the target firms. After considering the endogenous relationship among acquisition premium, payment method, and majority control based on a simultaneous equation model, the positive relationship between asymmetric information and acquisition premium continues to exist. We also conduct various robustness tests with respect to the choice of information asymmetry proxy, estimation period and the correction of sample selection bias and find that the results do not change. We argue that acquiring firms pay high premium in order to gain majority control in the target firms to mitigate the information asymmetry problem and to access more valuable private information resources that are not accessible to public investors.
KONSTRIBUSI KNOWLEDGEMANAGEMENT DALAM MENGEMBANGKAN DAN MEMPERTAHANKAN COMPANY’S COMPETITIVE ADVANTAGE

The method used in this studydescriptive qualitative approach. The data used are primary data obtained through field survey. The object of research are employees of PT. Putra Mustika Prajasa Cargo (PMPC) Jakarta with a population of 137 people were directly sampled. The sampling technique in this study using census method. Knowledge into a powerful force to win the competition in this knowledge economy era Executives and managers who manage and direct the organization needs the support of information and knowledge in developing corporate strategy and perform better decisions in order to maintain and build a strong competitive edge. How does an organization manage information and knowledge will be a critical success factor to become the market leader. Knowledge that contain experience, intuition, best practices and lessons learned into intangible assets which can be used to achieve the goals and objectives. The management system will process, store, retrieve, communicate and share data, information and knowledge becomes a tool to create value for the organization and shareholders and accelerate the development of culturally appropriate to become a knowledge-based organization. The results showed no major competitive advantage of knowledge, and for a company to be put into practice knowledge management operations. Pengetahuan menjadi kekuatan yang kuat untuk memenangkan persaingan dalam pengetahuan ini ekonomi Eksekutif era dan manajer yang mengelola dan mengarahkan organisasi membutuhkan dukungan informasi dan pengetahuan dalam mengembangkan strategi perusahaan dan melakukan keputusan yang lebih baik dalam rangka untuk mempertahankan dan membangun keunggulan kompetitif yang kuat. Bagaimana sebuah organisasi mengelola informasi dan pengetahuan akan menjadi faktor penentu keberhasilan untuk menjadi pemimpin pasar. Pengetahuan yang mengandung pengalaman, intuisi, praktik terbaik dan pelajaran menjadi aset tak berwujud yang dapat digunakan untuk mencapai tujuan dan sasaran perusahaan. Sistem manajemen pengetahuan satu collect, memproses, menyimpan, mengambil, berkomunikasi dan berbagi data, informasi dan pengetahuan menjadi atool untuk menciptakan nilai bagi organisasi dan pemegang saham dan mempercepat pengembangan budaya yang tepat untuk menjadi organisasi berbasis pengetahuan. Paper adalah tinjauan literatur yang ada pada diskusi masalah . A pakah keunggulan kompetitif utama pengetahuan? Bagaimana sebuah perusahaan akan menempatkan manajemen pengetahuan dalam praktek? Apakah Praktek manajemen pengetahuan akan menghasilkan keunggulan kompetitif dan mempertahankan itu? Ini lah isu-isu dan fokus terkait dari tulisan ini.
Studies on the ecology of the papillose allocreadiid trematodes of the yellow perch in Algonquin Park, Ontario.

Distribution and abundance of adult worms of Bunodera sacculata, Bunodera luciopercae, and Crepidostomum cooperi were examined. Bunodera species were restricted to perch, were found in fish from both deep and shallow water, but were more common in large rather than small lakes. Infection was independent of sex of perch for all three flukes. Bunodera luciopercae, and to a lesser extent B. sacculata, increased in incidence with increase in length and age of perch, but C. cooperi did not. Incidence of Bunodera species declined in summer; C. cooperi incidence did not. It was experimentally determined that differential sensitivity of adults of all three species to increased temperature was related to seasonal changes in incidence. The microhabitat of juvenile B. luciopercae was the gallbladder, but of B. sacculata and C. cooperi it was the intestine. Adults of C. cooperi were found predominantly in the intestinal ceca, of B. sacculata anterior intestine, and of B. luciopercae posterior intestine. The coexisten.
Changes in Glaucoma Medication during the Past Eight Years and Future Directions in Japan Based on an Insurance Medical Claim Database

Purpose To investigate changes in the status of glaucoma care between 2006 and 2013 and to predict future directions of glaucoma care in Japan. Subjects and Methods Japanese subjects registered in the largest national insurance claim database in Japan from 2006 to 2013 were analyzed. Estimations of the number of glaucoma patients during the past eight years and of the number of future patients were calculated. Changes in prescription trends among the same patients in the three-year period after initiating antiglaucoma medication were also investigated. Results There was a total of 3,016,000 subjects in the database. The proportion of glaucoma patients increased consistently from 2.5% in 2006 to 4.5% in 2013. This trend was predicted to continue until 2025, followed by a constant decrease with age. The most frequently prescribed antiglaucoma medications were prostaglandin analogues (PGs); however, in recent years, fixed combination therapy has emerged as a major treatment. Among 2856 newly diagnosed glaucoma patients; 94.7% of the patients initially received a single medication, but 25% of the patients received additional medications within 3 years. Conclusions The prevalence of glaucoma patients has significantly increased during the past eight years. The number of antiglaucoma medications continuously increased during the treatment period.
Securing Diversity for Food Security: The Case of Conservation and Use of Rice Genetic Resources

Producing enough food, fiber, and fuel, in this case, the second most important global crop called rice, remains a continuing challenge as global population increases and various production constraints ensue. Plant breeding scientists prefer using elite rice lines but also infuse new genetic resources into the parental genepool for desirable traits, such as resistance to pests and diseases, good flavor, and high nutritional quality on top of high-yielding potential. Prior research studies reveal the importance of germplasm resources including wild rice relatives as excellent sources of desirable traits in new crop breeds. Advances in molecular and genomics approaches (QTLs, GWAS, OMICs technologies) have identified and transferred genes, genomes, loci among other important genetic materials that are sought for. As knowledge builds up with these biotechniques, more rice genetic resources can be characterized at the molecular and systems levels for further utility in breeding better cultivars. Information generated from innovative approaches must be documented and processed as germplasm characterization data and must remain accessible at genebanks that exist centrally to conserve biodiversity. Development of germplasm information should be a collaborative effort of scientists who share similar interests in exploiting the valuable and novel genes within germplasm resources that are essential for crop improvement.
Rethinking Long Term Incentives in Indian Context

Dr. Amit Pande is a Deputy General Manager with Bennett, Coleman & Co. Ltd. (The Times Group) and works as a HR Business Partner. He is a Fellow (Doctorate) of Indian Institute of Management Ahmedabad. Prior to joining BCCL, he has worked with several consulting fi rms such as Aon-Hewitt, Corporate Executive Board & Grow Talent (Right Management Consultants) and has led several large assignments in fi eld of Organization Development, HR Process Redesign, Leadership Interventions, Executive Compensation, Employer Branding and Change Management with fi rms in India, Middle East and South East Asia.
Detection of a new mumps virus genotype during parotitis epidemic of 2006–2007 in the State of São Paulo, Brazil

Nucleotide sequence analyses of the SH gene of 18 mumps virus isolates collected in the 2006–2007 parotitis epidemic in the state of São Paulo identified a new genotype, designated genotype M. This new designation fulfills all the parameters required to define a new mumps virus genotype. The parameters were established by an expert panel in collaboration with the World Health Organization (WHO) in 2005. This information will enhance the mumps virus surveillance program both at the national and global levels. J. Med. Virol. 80:323–329, 2008. © 2007 Wiley‐Liss, Inc.
Species concepts and malaria parasites: detecting a cryptic species of Plasmodium

Species of malaria parasite (phylum Apicomplexa: genus Plasmodium) have traditionally been described using the similarity species concept (based primarily on differences in morphological or life–history characteristics). The biological species concept (reproductive isolation) and phylogenetic species concept (based on monophyly) have not been used before in defining species of Plasmodium. Plasmodium azurophilum, described from Anolis lizards in the eastern Caribbean, is actually a two–species cryptic complex. The parasites were studied from eight islands, from Puerto Rico in the north to Grenada in the south. Morphology of the two species is very similar (differences are indistinguishable to the eye), but one infects only erythrocytes and the other only white blood cells. Molecular data for the cytochrome b gene reveal that the two forms are reproductively isolated; distinct haplotypes are present on each island and are never shared between the erythrocyte–infecting and leucocyte–infecting species. Each forms a monophyletic lineage indicating that they diverged before becoming established in the anoles of the eastern Caribbean. This comparison of the similarity, biological and phylogenetic species concepts for malaria parasites reveals the limited value of using only similarity measures in defining protozoan species.
Robust stabilization of uncertain kinematic systems in nonholonomic mobile robots with one trailer

Based on visual servoing feedback, this paper provides a novel uncertain model of the kinematic systems in nonholonomic mobile robots with one trailer with uncalibrated visual servoing parameters. The strongly nonlinear disturbances and drift terms in its uncertain chained form of this model fails to meet the so called triangularity condition. The methods available in the literatures are not suitable to be used to investigate its stabilizing problem of the system. In order to deal with this difficulty, the special structure of the systems is exploited to design the stabilizing controller, which is divided into three phases. In the first phase, a newly state transformation is exploited to propose a stabilizing controller to make most of the states of the system tends to zero only excepts one state. In the second phase, the left state is stabilized and the other states remain little change by designing another controller. In the final phase, the control inputs can be set zero. The states remain constant. Finally, the simulation is presented to illustrate the stabilizing performance of the developed control algorithm.
Macroeconomics and Life Satisfaction: Revisiting the “Misery Index”

Using data from surveys of life satisfaction, evidence has been presented that European citizens' subjective well-being is inversely related to inflation and unemployment. Motivated by the “Barro Misery Index”, this paper reconsiders the relationship between macroeconomics and subjective well-being by including the growth rate and the long-term interest rate as additional variables in life satisfaction regressions. The paper finds that people care about growth and employment on the one hand and stability on the other, where stability may alternatively be captured by the inflation rate or the long-term interest rate. Stability, measured in whichever of these ways, does not seem to be less important to European citizens than growth and employment.
An Analysis of the Impact of WannaCry Cyberattack on Cybersecurity Stock Returns

This research examines the impact of the WannaCry cyberattack, considered to be the defining event for cyber threats, on stock returns of companies operating in the cybersecurity industry on the first trading day after the event. The aim is to ascertain whether the reaction of stock prices on this day could be classified as abnormal and which direction they follow. The expectation is for a demand shift for the products and services offered by these firms and consequently stock markets should reflect this new information in equity prices. Literature has mostly focused on natural catastrophes and lately on man-made catastrophes like terror attacks. This study explores the emerging area of cyberattacks which could develop into catastrophic situations. Event-study methodology is employed for the analysis of this specific event and results clearly indicate that WannaCry had a positive effect on the equity returns of cybersecurity companies and cybersecurity investment vehicles.
Physics-integrated hierarchical/distributed HVAC optimization for multiple buildings with robustness against time delays

In this paper, we address energy management for heating, ventilation, and air-conditioning (HVAC) systems in multiple buildings, and present a novel hierarchical/distributed optimization algorithm based on passivity. After formulating a thermal dynamics and an associated optimization problem across multiple buildings, we present a novel physics-integrated hierarchical/distributed optimization algorithm based on so-called primal-dual algorithm and the algorithm presented in [7]. We then prove convergence of the zone temperatures to the optimal ones based on passivity. The algorithm is further extended to ensure robustness against inter-layer time delays using scattering transformation. The present algorithm is finally demonstrated through simulation.
Mechanical properties of guinea pig taenia coli muscles.

Conditions have been established under which taenia coli muscles give consistent responses to electrical stimulation in experiments lasting up to 8 h. Using a new definition of resting length different muscles show similar mechanical characteristics. In agreement with previous investigations the mechanical behaviour of taenia coli is found to be qualitatively similar to vertebrate skeletal muscles. Compared with frog sartorius (a) the active tension per unit area is similar, (b) the maximum power output about 80 times less, (c) 90% of he maximum active tension is developed over a range of lengths abaut twice as great. Experiments with iodoacetic acid indicate that a condition of rigor can exist in this muscle.