Miracle-dz/UniFAR-FTUs huggingface dataset:
Host genetics affected the resistome and its expression patterns in the rumen of beef cattle raised without antibiotics used in humans

Background: The rumen microbiome is a potential reservoir of antimicrobial-resistant genes (ARGs), termly resistome. However, the activity of ARGs and what factors affect expression of ARGs in the rumen is unknown. Here, the rumen resistome was evaluated using metagenomic and metatranscriptomic datasets, with the aim to identify the active rumen resistome and whether it can be affected by cattle breed and feed efficiency.Results: Genes encoding resistance to 12 ARG classes representing 62 individual ARGs were detected in the rumen metagenomes of Angus, Charolais or Kinsella composite hybrid (KC) beef steers (n = 48) with high and low feed efficiency. Three genes encoding tetracycline (tetQ, tetW) and macrolide (mefA) resistance constituted 75.3% of abundance of total ARGs identified in all animals, suggesting they are ‘core’ resistome in the rumen of steers. Only about 20.96% (13/62) of the total ARGs identified were expressed, among which genes encoding resistance to tetracycline, macrolide-licosamide-streptogramin (MLS), aminoglycoside, and multidrug exhibited the highest level of expression. More than half (56.2%) of the ARGs identified were plasmid-associated, while only 5 plasmid-associated ARGs were expressed. The abundance of 17, 14, and 5 individual ARGs were significantly affected by breed, feed efficiency, and breed × feed efficiency, respectively, while the expression of ARGs did not differ among breeds or between feed efficiency groups. In KC cattle, less number of total ARGs, ARG transcripts, as well as total active bacteria (estimated by 16S rRNA copies) was observed than AN. The total active bacteria were negatively correlated with expression of MLS and tetracycline ARG (mefA, tet40, tetM, tetW, and an unidentified tet), and tended to be negatively correlated with the expression of plasmid-associated tetracycline ARG t only in the rumen of KC cattle.Conclusions: Our results suggest that a large portion of the ARGs are not expressed in the rumen of cattle raised without antibiotics used in humans. The identified less diversified active resistome and total active bacteria, and the significant correlation between total active bacteria and the abundance of ARG transcripts in KC cattle suggest that the expression of resistome in the rumen may be breed specific and driven by ruminal microbiota.
Peran Mediasi Competitive Advantage Pada Pengaruh Antara Learning Orientation Dengan Organization Performance

This research is intended to discuss the role of competitive advantage as a median variable between learning orientation and organizational performance. The research was conducted on SMES (small medium Enterprises) in Malang City as much as 150 SMES and from the questionnaires that were disseminated in analysis as many as 134 questionnaires, which were analyzed using SmartPls 2 program. The results showed that the effect of learning orientation on organization performance on total effects showed a value of β = 0,511 with a value of t = 7,370 > 1,86 (t table α = 5%) statistically significantly affected. Learning orientation also has a positive effect on competitive advantage with the coefficient β = 0,670 and the value of t = 7,889 > 1,86 (t table α = 5%). Competitive advantage also has a positive effect on organizational performance with β = 0,248 and t value = 2,501 > 1,86 (t table with α = 5%). Competitive advantage is proven to mediate the effect of learning organization on organizational performance with a coefficient β on total effects of 0,511 and t = 7,370> 1,86 (t table at α = 5%) with partial mediation. Keyword: Competitive advantage; learning orientation; organization performance
The epidemiological situation of morbidity and mortality on HIV / AIDS cases in Poland and globally in recent years

Aim: The aim of this review is to summarize the data on the morbidity and mortality of HIV / AIDS in the years 2000-2020 in Poland and in the world. As a result of continuous insufficient diagnostics, still millions of people are not aware of the disease, which often results in regions or countries with a significantly increased incidence. We were looking for information about the impact of the current COVID-19 pandemic on the production, distribution, and prices. Availability of drugs, especially in middle and low income countries, was also examined. Materials and methods: PubMed databases and statistics from the National Institute of Public Health (NIZP- PZH) and global data from the websites of WHO, UNAIDS - Global HIV & AIDS statistics and HIV.gov were searched in June and July 2020. The UNAIDS 90-90-90 program was also assessed. This programme was run until 2020. In the PubMed database, we used medical terms "hiv", "aids", "hiv / aids". No language restrictions were added. Conclusion: UNAIDS report on the global AIDS epidemic shows that 2020 targets will not be met because of deeply unequal success; COVID-19 risks blowing HIV progress way off course. Missed targets have resulted in 3.5 million more HIV infections and 820 000 more AIDS-related deaths since 2015 than if the world was on track to meet the 2020 targets. In addition, the response could be set back further, by 10 years or more, if the COVID-19 pandemic results in severe disruptions to HIV services. Currently, the world is plunged into the fight against COVID-19 and people are forgetting that the HIV pandemic also carries a large number of deaths. Nevertheless, the spread of both viruses is different and in developed countries the possibility of significant spread of HIV is much lower than in poor countries. The spread of Sars-Cov2 virus is much more difficult to control. Although the risk of serious illness from COVID-19 for people with HIV is not known, people with HIV may have concerns and questions related to their risk. COVID-19 pandemic has seriously impacted the AIDS response and could disrupt it more. Progress in prevention of HIV transmission remains too slow and the estimated total number of new infections in 2019 is more than three times higher than the UNAIDS 2020 target. Despite advances in the scientific understanding of HIV and its prevention and treatment, and many years of significant efforts by the global health community and governmental and community organizations, too many HIV-positive people still lack access to prevention, care and treatment. There is still no cure for everybody with HIV / AIDS. Moreover, the HIV epidemic not only affects human health, but also strikes households, communities, and the development and economic growth of nations.
The Use of Mobile Phone as Teaching Aid On EFL Students’ Speaking Performance and Perception

Abstract: This paper presents the effect of Mobile Phone on EFL Students’ speaking performance and perception. While mobile phone has been utilized beyond its primary use as a communication tool, there are only a limited number of studies in pedagogy which highlights the importance of mobile phone in teaching-learning activities. The objective of this paper is to show the effect of Mobile Phone as teaching aid on EFL Students’ speaking performance and perception. The result of this study shows students who taught using mobile phone outperformed students who taught by conventional teaching.Abstrak: Penelitian ini berisi tentang pengaruh dari mobile phone terhadap kemampuan bahasa Inggris dan persepsi dari siswa. Banyak kegunaan mobile phone selain sebagai alat komunikasi, namun hanya sedikit yang membahas kegunaan mobile phone di dalam kegiatan belajar mengajar. Penelitian ini bertujuan untuk melihat pengaruh dari mobile phone sebagai bahan bantu pengajaran terhadap kemampuan berbicara siswa. Hasil dari penelitian ini menunjukkan siswa yang belajar dengan menggunakan mobile Phone memiliki pencapain yang lebih baik daripada siswa yang belajar menggunakan cara konvensional.
Don’t intubate women with pneumothorax. Surgery with music and muse

Background: Treatment of women with spontaneous pneumothorax is challenging and multidisciplinary. We performed a retrospective analysis of 10 females with spontaneous pneumothorax to determine the clinical features as well as the effects of treatment and recurrence rates. Our goal was to report that non-intubated video-assisted thoracic surgery is feasible and safe treatment of pneumothorax in women. Methods: A retrospective review was conducted of the clinical and pathologic data in all 10 patients undergoing treatment at our institution. 4 patients undervent treatment for catamenial pneumothorax. All 10 patients underwent surgical treatment. Results: The median age was 33 years. The laterality of the pneumothorax was right in 7, left in 3 patients. All patients underwent surgical treatment. Partial resection of the lung was performed in 10 patients and partial resection of the diaphragm with mesh diaphragm augmentation in four. Of these, both resections were performed in four patients. A pathological diagnosis of endometriosis was achieved in only four patients. The observation period was 6 months. No recurrences were observed. 8 patients were operated in the 1, 1 in
On the Necessity of Diversified Ownership Reform of State-owned Monopolistic Enterprises from the Perspective of Real Earnings Management

2020 is a crucial year for the reform of state-owned enterprises. In order to promote the balanced development of national economy and deepen the market-oriented reform of state-owned enterprises, it is the top priority in the diversified ownership reform to break the monopoly barriers of state-owned enterprises. Market-oriented reform, which is conducive to exerting the market’s supervisory effect, can play a favourable part in reducing the manipulation of real earnings management and improving the corporate governance capabilities of state-owned enterprises. Therefore, from the perspective of real earnings management, empirical analysis is conducted in this paper to demonstrate that there is a significantly positive correlation between the monopoly power of state-run enterprises and real earnings management. It is found through case analysis that diversified ownership reform of state-run enterprises is conducive to breaking the monopoly barriers of state-owned enterprises, reducing monopoly power, improving corporate governance as well as lowering the manipulation of real earnings management.
Selected Thermodynamic Parameters of Antioxidant Activity of Coumarin Based Heterocyclic Compounds

Coumarin and coumarin derivatives are bioactive compounds that have an important role in medicinal chemistry, for example in the development of anti-inflammatory, anticancer and antiviral drugs. These compounds are also very powerful antioxidants that successfully scavenge free radicals and prevent or alleviate oxidative stress. The antioxidant potential of selected heterocyclic compounds containing coumarin core was investigated theoretically, the focus of this study was on hydrogen atom transfer mechanism (HAT) and single electron transfer followed by a proton transfer mechanism (SET-PT). Using MOPAC2012 PM7, reaction enthalpies related to the cleavage of O–H, N–H and C–H bonds via selected mechanisms of free radical scavenging were studied and calculated. The effect of the position of the hydroxyl group, as well as other functional groups, on the antioxidant activity, was examined. Based on obtained results, Schiff bases, thiosemicarbazides, oxadiazoles and 4-thiazolidinones containing one or more OH– groups exhibit higher radical scavenging properties.
Problems, Challenges, and Opportunities Visualization on Big Data

Today, almost everything is recorded digitally, from our browsing history to our health records in hospitals, we make and process billions of data every day. In this era of big data, large amounts of data are continuously obtained for different purposes. But, just processing and analyzing the data are not enough. If data is displayed visually, humans always search for patterns more effectively. Visualization and interpretation of the data are very critical tasks in making choices in various industries. This also guides us to new ways to find innovative ideas through visualization to solve big-data problems. In this paper, we will discuss the problems, challenges, and potential of Visualization in Big Data
Joint and Survivor Annuity Valuation with a Bivariate Reinforced Urn Process

We introduce a novel way of modeling the dependence of coupled lifetimes, for the pricing of joint and survivor annuities. Using a well-known Canadian data set, our results are analysed and compared with the existing literature, mainly relying on copulas. Based on urn processes and a one-factor construction, the proposed model is able to improve its performances over time, in line with the machine learning paradigm, and it also allows for the use of experts’ judgements, to complement the empirical data.
Thematic Exploration of Corporate Social Responsibility (CSR) Issues: Origins, Twists and Turns, and Evidence from Nigeria’s Oil and Gas Industry

The CSR conceptualization motives are products of the prevailing socio-cultural, economic and political priorities of the company-host communities’ relationships, and realities. In some cases also, available relevant evidences suggest that until recently, the evolution, adoption and development of CSR policies and strategies within Nigeria’s oil and gas industry in specific, were a calculated defensive strategy adopted by the multinational companies (MNCS) to help reduce costs of operation, mitigate and minimize reputation damaged resulting from frequent community strife (ldemudia and lte, 2006; Chikwe, 2012, Chikwe and Zeb-Obipi, 2017). To ameliorate this ugly situation in Nigeria, a strategy of Corporate-Community Relations (CSR) in Nigeria’s oil and gas industry was crafted, and this became an integral part of CSR umbrella initiative in the oil and gas producing region of Nigeria. Abstract: This paper discusses the corporate social responsibility, its origins, twists and turns, as well as some impacts and evidence from oil and gas industry in Nigeria. Efforts were made in capturing and integrating some global evolutionary and historical phases of attitudes towards social responsibility starting from Adam Smith’s (1776) wealth of Nations perceptions, Milton Friedman (1970), Carroll (1991), Claydon (2011), and recent perspectives. Some areas relating to corporate social responsibility debate, and the views reconciliation were examined. Empirical evidences from oil and gas companies’ corporate responsibility positive impacts on host communities lives were also explored and statistically examined. We conclude amongst others that corporate social responsibility engenders mutual cooperation and socio-economic development. Corporate organizations should be environmentally sensitive and people-friendly, such helps to minimize conflicts and enhancement of operational environment sustainability as recommended herein.
Pretreatment Absolute Neutrophil-to-Lymphocyte Ratio (NLR) Predict the Risk for Febrile Neutropenia in the First Cycle Adjuvant Chemotherapy for Breast Cancer

Background: Chemotherapy-induced febrile neutropenia (FN) is a condition affecting mortality and morbidity. The records show that absolute neutrophil-to-lymphocyte ratio (NLR) is associated with the cancer prognosis and reflects the immune response system on the infection. It can be used as an independent prognostic biomarker and predictive marker in patients with chronic inflammatory diseases, cardiovascular diseases, or malignancies. Therefore, we have been conducted on using absolute NLR to predict FN in a patient with breast cancer who has adjuvant chemotherapy. Materials and Methods: The authors retrospectively evaluated the pretreatment absolute NLR of patients with early stage breast cancer who had adjuvant chemotherapy. Then, the relationship to FN was analyzed by using multivariate logistic regression analysis. Results: We conducted a retrospective analysis of 339 patients where 21 patients had developed FN (6.19%). The multivariate logistic regression analysis results indicated that the pretreatment absolute NLR cut-off point equal to or greater than 2.4 was a significant independent predictive biomarker of the chemotherapy-induced FN (odds ratio = 2.810, 95%,; CI 1.061 - 7.442; p = 0.038). The predictive performance of the high level of absolute NLR was an acceptable discrimination [AUC= 0.7626 (95% and CI 0.650 - 0.875)]. Furthermore, a calibration curve and the Hosmer-Lemeshow test to assess the accuracy of the predictive model showed a goodness of fit for a logistic predictive model (Hosmer-Lemeshow chi2 = 2.50; p = 0.645). Conclusions: Pretreatment absolute NLR would be a useful predictive biomarker for febrile neutropenia after the first cycle of adjuvant chemotherapy for breast cancer that would be simple and easy to integrate in daily practice without extra costs.
Effect of aloe preparation and 5-oxo-1,2,4-triazine on mineral composition of tissues of turkey hens subjected to stress

ABSTRACT The aim of this study was to determine the influence of aloe preparation and 5-oxo-1,2,4-triazine on mineral composition of muscles and liver of turkey hens under conditions of stress. Groups C and C (+)stress were control that did not receive any additive. Birds from groups A and A (+)stress were administered aloe preparation in a dose of 0.70 ml/kg (BW)/day. Turkey hens from groups T and T (+)stress received 5-oxo-1,2,4-triazine in a dose of 30 μg/kg BW/day. The applied stress factors did not affect the mineral composition of the analysed tissues of turkey hens. Administration of 5-oxo-1,2,4-triazine caused a significant decrease in iron concentration and an increase in zinc concentration in thigh muscles and liver. In turn, aloe preparation contributed to an increase in tissue levels of calcium (except for shank muscles), zinc (in leg muscles and liver) and copper (in thigh muscles). A decrease in iron concentration in leg muscles and liver in birds supplemented with aloe preparation was also determined.
Treatment experience of large intraventricular central neurocytoma: a retrospective cohort study

Background: Central neurocytoma is a rare intracranial tumor. Due to the limited number of reported cases, the treatment strategy for central neurocytomas, especially large central neurocytomas, remains controversial. This paper discusses our clinical experience in the treatment of large central neurocytomas.Methods: A retrospective analysis of 29 patients with intraventricular central neurocytomas diagnosed and treated by the same surgeon between April 2012 and September 2019 at the Neurosurgery Departments of Beijing Tiantan Hospital and Hainan General Hospital was performed. The clinical characteristics, treatment plans and prognoses of these patients were reviewed.Results: Among the 29 patients, the average age of onset was 31.93 (17-61) years, and the average maximum tumor diameter was 54.17 ± 15.62 mm. Twenty-three patients (79.3%) had an average maximum diameter greater than 50 mm. Twenty-seven patients (93.1%) underwent transcortical tumor resection. Twenty-seven patients (93.1%) underwent gross total tumor resection. Five patients (17.2%) received radiotherapy after the first operation, and 3 patients (10.3%) had tumor recurrence. None of the patients died.Conclusions: Surgical resection via transcortical fistulotomy is a reliable approach for removal of large central neurocytomas in the ventricle. Patients should be closely observed postoperatively, and MRI of the head should be performed regularly. If a tumor shows progression, then radiotherapy should be considered.
Theoretical Approach to Entrepreneurship: A Review of Literature

Entrepreneurship is a field of research that is considered today to be of very considerable importance, given its impact on the global economy and on the human development of modern societies. This position is reflected in the scope of the entrepreneurial individual, who is seen as the central axis that moves and structures success of the entrepreneurial process. The purpose of this paper is to define the entrepreneurial project related to the concepts of entrepreneurship based on the fundamental concepts of the entrepreneur and the entrepreneurial process. Entrepreneurship seems as a strategic and operational construct at first a glance, which makes it possible to put in place the managerial strategies that will be conducted according to the attitude and aptitude of the entrepreneur. The latter is likely to seize and successfully exploit the targeted opportunity. Thus, this reformulation work makes it possible to describe the entrepreneurial phenomenon. This section of the literature review provides a better understanding of the key concepts that constitute the necessary condition for the classic operation of the entrepreneurial approach.
STRATEGI KAMPANYE DAN KEMENANGAN RIDWAN KAMIL DALAM PILGUB JABAR 2018

The Election of Governor of West Java 2018 was regarded as a very strategic Local Election because it had the biggest number of Electors in Indonesia, that so it is assumed to have significant influence for Legislative and President Elections in 2019. This Election was winned by Ridwan Kamil-Uu Ruzhanul Ulum. Before the campaign periode, Ridwan Kamil was assumed would be “attack” by religion issues which is predicted having role in defeating Ridwan Kamil in The Election of Governor of West Java 2018, and many negative news were exposed in social medias in order to discredit Ridwan Kamil’s image. Therefore, the analysis of Ridwan Kamil’s campaign strategy in winning The Election of Governor of West Java 2018 is so interesting. This research uses qualitative method, and the datas or facts are analysed by descriptive analyse method. The results of this research could be used as informations in winning local election political strategy for next local leader candidates. This analysis shows that Ridwan Kamil implemented the effective campaign strategy of political images and political positioning. Those two political strategies combination were absolutely difficult to be duplicated by his rivals.
Prospect and Problems of Tourism Development in Nepal : A Case Study on Bhaktapur Darbar Square

Tourism sector is a very importance in Nepalese’s economic activities. In this sector there are so many problems and opportunity. In this research had analysed the problems and prospects of tourism development in Nepal with reference to BhaktpurDurbar Square (BDS) in Bhaktpur district. Primary data were used for the main information and secondary data also used for supplementary sources of information. Primary data collected by direct personal interview through semi-structural questioner. Both local trade/business people and tourist those who were available in the time of survey were used as a samples.Tourist visit here for holiday pleasure, business and research purpose. Length of tourist stay is very few and time of re visit also few. For the development of tourism sector Nepal increase physical facilities and improve infrastructure of old and new tourism destination.