Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardiovascular Risks of Cyclooxygenase Inhibition

Millions of patients use nonsteroidal antiinflammatory drugs (NSAIDs) for relief of arthritic pain. Although NSAIDs reduce pain, their use has been linked to gastroduodenal complications. Selective inhibition of the cyclooxygenase (COX)‐2 enzyme appeared to offer patients similar pain relief with an improved adverse‐effect profile. However, accumulating experiences have raised concerns regarding the cardiovascular toxicities of the selective COX‐2 inhibitors. Although selective COX inhibitors provide more gastrointestinal protection than NSAIDs, the unbalanced inhibition of prostaglandins may promote cardiovascular complications. Variability in study designs and inconsistency in results have made the evaluation of NSAID and COX‐2 inhibitor safety very difficult, creating confusion among health care practitioners. We examine the pharmacologic and clinical evidence that defines the cardiovascular risk associated with COX inhibition.
On the Effect of Combination of Statistical and Judgemental Stock Control Methods

Stock control is the most important aspect in an inventory system. It determines the safety stock in order to ensure that products are readily available when the customers require them. The decision makers in organizations tend to rely on software solution in obtaining stock control solutions since they have to manage a massive number of Stock Keeping Units (SKUs). However, managers intervene in the system and use their judgement to adjust or decide on various quantitative elements. This research discusses the effects of combination of stock control methods. An extended database of approximately 1,800 SKUs from an electronics company is analyzed. Then, a simulation experiment is performed in order to evaluate in a dynamic fashion what are the effects of applying combined stock control methods. The findings indicate that the combined method of stock control seems to improve the performance of the inventory system, especially in reducing inventory investment.
Children's understanding of homonyms

ABSTRACT Previous tasks have shown that preschool and early elementary school-children typically have trouble learning and identifying homonyms (Peters & Zaidel, 1980; Mazzocco, 1989). It is possible that a one-to-one mapping assumption or a lack of metalinguistic skills makes homonym learning and identification particularly difficult. In three experiments we examined a total of 60 three-year-olds' ability to pick out homonym pairs, and the extent to which they realize that although homonyms share a common label, they represent two different categories. In Experiment 1 subjects were asked to identify homonym pairs. In Experiment 2, homonym pairs and non-homonym pairs were labelled, then children were asked whether the pairs had the same name, and whether they were the same kind of thing. In Experiment 3 children were shown one-half of each of several homonym and non-homonym pairs, then asked to identify a name match and a category match from a set of pictures. From these experiments we conclude that children have the metalinguistic skills necessary to identify homonym pairs; moreover, they realized that homonyms represent two different categories. Finally, if children have a one-to-one mapping assumption, it is not strong enough to prevent them from acquiring homonyms.
Integrated geosptial sensor web for agricultural soil moisture monitoring

As an important variable in agriculture, especially in precision agriculture and drought, soil moisture has received increasing attentions. How to collaborate multi-platform sensors to obtain spatial-temporal continuously soil moisture monitoring is a main challenge. This paper overviewed an integrated geospatial sensor web for agricultural soil moisture monitoring in China. In this sensor web, satellite sensors (i.e., GF-1), in-situ sensors (i.e., BDS-R), and wireless sensor networks were firstly coupled by sensor web based cyber infrastructure. Then multi-sensor collaboration methods were designed to make full use of these different monitoring capabilities. In addition, web processing service was utilized to achieve online soil moisture estimating, fusing, and mapping. Finally, an integrated online service platform was constructed to query and display all soil moisture related resources. The experiments conducted in Hubei province demonstrated that this region's agricultural soil moisture monitoring capability was improved in terms of spatial-temporal continuity and accuracy. Therefore, the integrated geospatial sensor web is a powerful infrastructure for agriculture monitoring.
Hierarchical correlation for content-based image retrieval

This report proposes a hierarchical correlation calculation approach to content-based mammogram retrieval. In this approach, images are represented as a Gaussian pyramid with several reduced- resolution levels. A global search is first conducted to identify the optimal matching position, where the correlation between the query image and the target images in the database is maximal. Local search is performed in the region comprising the four child pixels at a higher resolution level in order to locate the position with maximal correlation at greater resolution. Finally, this position with the maximal correlation found at the finest resolution level is used as the image similarity measure for retrieving images. Experimental results have shown that this approach achieves 59% in precision and 54% in recall when the threshold of correlation is ≥ 0.5.
Factors That Influence Critical Care Nurses' Intentions to Provide Culturally Congruent Care to Arab Muslims

The purpose of this study is to investigate the relationships among critical care nurses' attitudes, subjective norms, perceived behavioral control, and intentions to provide culturally congruent care to Arab Muslims. The provision of culturally congruent care is contingent on understanding nurses' motivational influences for providing culture care. Significant relationships among critical care nurses' behavioral beliefs, normative beliefs, control beliefs, intentions, and demographic variables supported the need for culture-specific debriefing sessions, underscored the importance of collaborative practice and interdisciplinary learning models, and established an evidence-based foundation for the design of culturally informed approaches to nursing education and service.
Design of a wideband quasi-Yagi microstrip antenna with bowtie active elements

This paper presents a novel wideband quasi-Yagi microstrip antenna with bowtie active elements. Good impedance matching and mode transforming are realized by using a microstrip line-to-slotline transition. In this design, a passive reflector and two passive rectangle directors are used to obtain End-fire radiation patterns. After FDTD and FEM simulations, a good agreement between them validates the accuracy and the reliability of the calculation of the antenna. The 10 dB return loss bandwidth of the proposed design is 70% operating from 4.4GHz to 9.6 GHz, and the gain of this proposed antenna is higher than 5dBi at most frequency band with broad radiation beam. With the advantages of compact size, light weight and easy fabricating, it is suitable for broadband wireless communications.
Direct load control considering interrupted energy assessment rate in restructured power systems

A direct load control (DLC) scheme of air conditioning loads (ACL), which considers the interrupted energy assessment rate (IEAR) of nodes where ACL are connected, is proposed in this paper for restructured power systems. The IEAR is utilized to determine the compensation for the discomfort of the ACL customers due to the service interruption caused by the DLC of ACL. Dynamic programming is used to determine the optimal DLC scheme of ACL under the minimum total system operating cost. The IEEE reliability test system is simulated to illustrate the proposed DLC technique of ACL.
The PRESAT‐vector: Asymmetric T‐vector for high‐throughput screening of soluble protein domains for structural proteomics

A rapid unidirectional method for cloning PCR‐amplified cDNA fragments into virtually any fusion protein expression vector is described. The method, termed PRESAT‐vector cloning, is based on a T‐vector technique that does not require restriction endonuclease digestion of the PCR product. Subsequently, we applied a novel ORF selection method of the ligated plasmid products. This second step involves restriction endonuclease treatment that eliminates the plasmids containing an ORF in the wrong orientation prior to transformation into the bacterial host for further protein expression studies. To achieve this selection, we customized the 5′‐sequence of the “rear” PCR primer corresponding to the C terminus of the protein to be expressed. The colonies harbored only the ligated products of the desired orientation at >90% efficiency. This method is applied to a GST fusion expression system, and an HTS system for soluble proteins from an expression library was tested.
An analysis of personal wireless network security in Tonga: A study of Nuku'alofa

This study evaluates the current state of wireless network security in the CBD of Nuku'alofa. Wireless Networks have grown significantly since their introduction. Security protocols supplied with the wireless equipment have reached a level of strong and robust security. However, security remains a problem; this study aims to answer two questions. What is the status of wireless network growth and security in Tonga? and what can be done to improve wireless network security in Tonga. The war-drive results of Nuku'alofa produced comprehensive data which clearly shows the number of networks, both company and home networks. An exploratory research approach is employed to guide the design of the study. The results show that there is a significant growth in terms of WLAN usage since the implementation of the fiber optic network. However, this study concludes that WLAN security in Nuku'alofa is still in its early stages.
Parent Perceptions of Illness Uncertainty and Child Depressive Symptoms in Juvenile Rheumatic Diseases: Examining Caregiver Demand and Parent Distress as Mediators.

OBJECTIVE Examine caregiver demand and general parent distress as mediators in the parent illness uncertainty-child depressive symptom association in youth with juvenile rheumatic diseases. METHODS Children and adolescents completed the Child Depression Inventory; caregivers completed the Parent Perceptions of Uncertainty Scale, the Care for My Child with Rheumatic Disease Scale, and the Brief Symptom Inventory. The pediatric rheumatologist provided ratings of clinical disease status. RESULTS Analyses revealed significant direct associations between illness uncertainty and caregiver demand, and between caregiver demand and both parent distress and child depressive symptoms. Results also revealed significant parent uncertainty → caregiver demand → parent distress and parent uncertainty → caregiver demand → child depressive symptom indirect paths. CONCLUSIONS Results highlight the role of illness appraisals in adjustment to juvenile rheumatic diseases, and provide preliminary evidence that parent appraisals of illness uncertainty impact parent distress and child depressive symptoms indirectly through increased perceptions of caregiver demand.
Relationships among MTHFR a1298c gene polymorphisms and methylation status of Dact1 gene in transitional cell carcinomas.

OBJECTIVES The purpose of this study was to determine the relationship between methylation status of the Dact1 gene and MTHFR a1298c polymorphic forms in transitional cell carcinoma tissues in a Chinese population. METHODS Polymorphisms of folate metabolism enzyme gene MTHFR were assessed by restrictive fragment length polymorphism (RFLP) methods and PCR-based DNA methylation analysis was used to determine the CpG island methylation status of the Dact1 gene. Associations between the methylation status of the Dact1 gene and clinical characteristics, as well as MTHFR a1298c polymorphisms, were analyzed. RESULTS aberrant methylation of the Dact1 gene was found in 68.3% of cancer tissues and 12.4% of normal tissues,. The methylation rate of the Dact1 gene in cancer tissues was significantly higher in patients with lymph node metastasis than in those without lymph node metastasis (46.3% vs. 17.2%, P = 0.018). No association was found between aberrant DNA methylation and selected factors including sex, age, tobacco smoking, alcohol consumption and green tea consumption. After adjusting for potential confounding variables, variant allele of MTHFR a1298c was found to be associated with methylation of the Dact1 gene. Compared with wild type CC, the odds ratio was 4.33 (95% CI: 1.06-10.59) for AC and 4.95 (95% CI: 1.18-12.74) for AA. The N stage in TNM staging and the occurrence of lymph node metastasis were associated with an MTHFR 1298 AAμAC genotype (P<0.05). CONCLUSION MTHFR 1298 AC and AA genotypes might help maintain a normal methylation status of the Dact1 gene, aberrant CpG island methylation of which is closely related to the genesis and progression of transitional cell carcinoma.
Use of positron emission tomography scanning to evaluate pseudoresponse.

Although an important part of the neuro-oncologists armamentarium, antiangiogenic chemotherapeutic agents can result in a pseudoresponse. This phenomenon occurs because the contrast enhancement that is used to measure tumor burden radiographically, depends upon the breakdown of the blood-brain barrier which may be restored after treatment with antiangiogenic agents, even without true eradication of the neoplasm. This occurrence may complicate attempts to determine an accurate prognosis for patients with malignant brain tumors as well as delay the initiation of more beneficial treatment strategies.
Non‐myeloablative hematopoietic stem cell transplantation in the treatment of severe idiopathic CD4+ lymphocytopenia

A 40‐year‐old man with severe chronic idiopathic CD4+ lymphocytopenia complicated with opportunistic infections was successfully treated with non‐myeloablative allogeneic hematopoietic stem cell transplantation. After conditioning with fludarabine plus low dose of total‐body irradiation, CD34+ peripheral blood stem cells obtained by leukapheresis from his HLA‐identical sister were infused. T cell and myeloid complete chimerism was achieved at day +28 and remained stable during the follow‐up period. The patient did not develop infectious complications during the procedure. At 35 months of follow‐up, his CD4+ T cell count was 1019 cells per microliter. Non‐myeloablative allogeneic hematopoietic stem cell transplantation should be considered a treatment option for patients with severe forms of idiopathic CD4+ lymphocytopenia.
Efficacy and Safety of Rilpivirine (TMC278) Versus Efavirenz at 48 Weeks in Treatment-Naive HIV-1–Infected Patients: Pooled Results From the Phase 3 Double-Blind Randomized ECHO and THRIVE Trials

Background:Pooled analysis of phase 3, double-blind, double-dummy ECHO and THRIVE trials comparing rilpivirine (TMC278) and efavirenz. Methods:Treatment-naive HIV-1–infected adults were randomized 1:1 to rilpivirine 25 mg once daily or efavirenz 600 mg once daily, with background tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) (ECHO) or TDF/FTC, zidovudine/lamivudine, or abacavir/lamivudine (THRIVE). The primary endpoint was confirmed response [viral load <50 copies per milliliter; intent-to-treat time-to-loss-of-virologic-response (ITT-TLOVR) algorithm] at week 48. The pooled data set enabled analyses of subgroups and predictors of response/virologic failure. Results:Confirmed responses were 84% (rilpivirine) and 82% (efavirenz). The difference in response rates (95% confidence interval) was 2.0% (–2.0% to 6.0%). The incidence of virologic failure was 9% (rilpivirine) versus 5% (efavirenz). Responses in ITT-TLOVR and ITT-snapshot analyses were consistent. Responses were similar for rilpivirine and efavirenz by background regimen, gender, race and clade. Suboptimal adherence and higher baseline viral load resulted in lower responses, higher virologic failure, and development of resistance in both groups; the effects on virologic failure were more apparent with rilpivirine. CD4+ cell count increased over time in both groups. Rilpivirine compared with efavirenz gave smaller incidences of adverse events leading to discontinuation (3% vs. 8%, respectively), treatment-related grade 2–4 adverse events (16% vs. 31%), rash (3% vs. 14%), dizziness (8% vs. 26%), abnormal dreams/nightmares (8% vs. 13%), and grade 2−4 lipid abnormalities. Conclusions:At week 48, rilpivirine 25 mg once daily and efavirenz 600 mg once daily had comparable response rates. Rilpivirine had more virologic failures and improved tolerability versus efavirenz.
Two‐Stage Life Histories in Fish: The Interaction Between Juvenile Competition and Adult Performance

Pumpkinseed sunfish (Lepomis gibbosus) typically exhibit a strong ontoge- netic diet shift. Small (juvenile) pumpkinseeds feed primarily on soft-bodied littoral in- vertebrates and compete with small bluegill (L. macrochirus), while large (adult) pump- kinseeds feed extensively on snails. We compared pumpkinseed and snail populations in two Michigan lakes that contain bluegill (Three Lakes II and Three Lakes III) with pop- ulations inhabiting Wintergreen Lake, a lake lacking bluegill. In the absence of bluegill, pumpkinseeds were abundant and juveniles grew well; however, snail abundances were low and adult pumpkinseeds grew poorly. Furthermore, no ontogenetic diet shift to snails occurred in Wintergreen Lake, and the pharyngeal muscles and bones used to crush snails were smaller than in fish from Three Lakes II. Pumpkinseeds from Wintergreen Lake also required significantly more time to crush and handle thick-shelled snails, but not thin- shelled snails and nongastropod prey, than did fish from Three Lakes II. In a field caging experiment in Wintergreen Lake snail densities increased fourfold when pumpkinseeds were excluded. Historical data as well as the among-lake comparisons suggest that the changes in Wintergreen Lake occurred in response to the selective elimination of the pumpkinseed's juvenile-stage competitor, the bluegill, via a winterkill event in the late 1970s. It appears that removal of bluegill released juvenile pumpkinseeds from competition and increased pumpkinseed recruitment into the adult stage, which resulted in the overexploitation of the adults' snail resource. These events then led to changes in adult pumpkinseed diet, growth, morphology, and feeding ability. These data are consistent with predictions from a two-stage life history model developed for the pumpkinseed-bluegill interaction and illustrate some of the important indirect consequences of interactions involving stage- structured populations.
Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First‐in‐Man) Clinical Trial

The number of donor organs suitable for liver transplantation is restricted by cold preservation and ischemia–reperfusion injury. We present the first patients transplanted using a normothermic machine perfusion (NMP) device that transports and stores an organ in a fully functioning state at 37°C. In this Phase 1 trial, organs were retrieved using standard techniques, attached to the perfusion device at the donor hospital, and transported to the implanting center in a functioning state. NMP livers were matched 1:2 to cold‐stored livers. Twenty patients underwent liver transplantation after NMP. Median NMP time was 9.3 (3.5–18.5) h versus median cold ischaemia time of 8.9 (4.2–11.4) h. Thirty‐day graft survival was similar (100% NMP vs. 97.5% control, p = 1.00). Median peak aspartate aminotransferase in the first 7 days was significantly lower in the NMP group (417 IU [84–4681]) versus (902 IU [218–8786], p = 0.03). This first report of liver transplantation using NMP‐preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation. NMP may be valuable in increasing the number of donor livers and improving the function of transplantable organs.
Exploring radio frequency identification technology and its impact on business systems

Purpose – To provide practitioners of management a sense of the importance of strategically leveraging the current and historic development of radio frequency identification (RFID) in order to find inexpensive applications of radio frequency‐based (RF) technologies in many areas.Design/methodology/approach – A review of the applied literature on RFID, as well as from practical experience, resulted in a basic model of viewpoint to understand the nature of the emergent RF‐based industry.Findings – Wal‐Mart and other cost sensitive and value chain progressive companies' usage of RFID‐based technology should revolutionize the method that companies' track inventory. However, some of the disadvantages include costs, training, product label and supplies, and privacy infringement. One asset to companies like Wal‐Mart is pallet tracking because it improves on‐time inventory delivery. This helps Wal‐Mart since they rely on just‐in‐time ordering.Research limitations/implications – RFID is currently used in many indu.
Coated Pits and Vesicles Transfer Plasma Components to Platelet Granules

Summary Electron microscopy of mammalian blood platelets after contrast enhancement with tannic acid after an initial fixation in glutaraldehyde and osmium reveals numerous coated pits (c.p.) and vesicles (c.v.), indicating a process of receptor-mediated endocytosis. The c.p. may be located at any site of the plasma membrane or the canalicular, surface connected membrane system. C.v. fuse with platelet granules without losing their coat. Evidence for a continuous transfer of ambient fluid to granules via c. p. and c.v. was obtained by the use of fluid-phase markers. It is proposed that the endocytic process may play a role in blood platelet activation.