Miracle-dz/UniFAR-FTUs huggingface dataset:
Antibiotic utilization in open fractures

Abstract Open fractures are complex presentations with elevated risks of infection and nonunion due to a multitude of factors. Along with early surgical debridement, antibiotics have been heavily utilized and have become part of standard of care to reduce the risks of fracture-related infections. Many aspects of their use have been studied and debated. The early administration of intravenous antibiotics has been shown to significantly reduce the incidence of infection. Furthermore, current standards do not recommend prolonged antibiotic administration post wound closure. Recently, an increasing number of studies have assessed the utility of locally administered antibiotics. Clinical and basic science studies have been relatively supportive of their usage, but further studies are still warranted to further delineate their effects.
Primary Spinal Cord Neurons Better Attach to Non-Coated Surfaces Than to Poly(D-lysine)-Coated Surfaces

Background: Cell culture is an important technique in cellular and molecular biology. There are two basic systems for culturing cells, adherent (monolayer) culture and suspension culture. In adherent cell culture, cellular adhesion molecules play a vital role in many physiological processes. Many cells, especially primary-obtained cells, hardly attach to plates, so coating agents are used for cell attachment and growth. There is no striking report on whether all cells need coated plates. Objectives: We investigated whether a coating plate is essential for primary spinal cord-obtained neuron culture. Methods: CellswereseparatedandseededintissuecultureplatescoatedwitheitherPoly(L-lysine)orPoly(D-lysine),aswellaswith-out coating containing DMEM-F12 media with 10% FBS. Results: Interestingly, we found that neuron cells more potently attached to coating free plates. Conclusions: These results provide strong evidence helping the researchers to optimize primary spinal cord cultures.
Iron Loss Minimization Strategy for Predictive Torque Control of Induction Motor

Today’s modern control strategies of an induction motor (IM) drive require a power source with an adjustable output voltage frequency and amplitude. The most commonly used converter topology is a two-level voltage-source inverter (VSI). However, the utilization of a VSI introduces additional voltage and current distortion, which leads to additional power losses in the machine’s magnetic circuit. Both the transistor switching frequency and the type of the inverter control determine the total harmonic distortion (THD) of the motor’s phase currents. In this paper, the influence of the inverter DC-link voltage on the iron losses of an IM controlled by a predictive torque control (PTC) is presented. It is shown that if the IM drive operates below the rated speed, it is possible to modify the PTC algorithm to reduce the additional iron losses caused by the non-harmonic inverter output voltage. The control of the DC-link voltage is achieved by using a silicon-controlled rectifier. Experiments were conducted on a 5.5 kW IM controlled by PTC, and the results are compared against a sinusoidal voltage supply created by a synchronous generator.
Seedling defoliation, plant growth and flowering potential in native- and invasive-range Plantago lanceolata populations

Hanley ME (2012). Seedling defoliation, plant growth and flowering potential in native- and invasive-range Plantago lanceolata populations. Weed Research52, 252–259. Summary The plastic response of weeds to new environmental conditions, in particular the likely relaxation of herbivore pressure, is considered vital for successful colonisation and spread. However, while variation in plant anti-herbivore resistance between native- and introduced-range populations is well studied, few authors have considered herbivore tolerance, especially at the seedling stage. This study examines variation in seedling tolerance in native (European) and introduced (North American) Plantago lanceolata populations following cotyledon removal at 14 days old. Subsequent effects on plant growth were quantified at 35 days, along with effects on flowering potential at maturity. Cotyledon removal reduced early growth for all populations, with no variation between introduced- or native-range plants. Although more variable, the effects of cotyledon loss on flowering potential were also unrelated to range. The likelihood that generalist seedling herbivores are common throughout North America may explain why no difference in seedling tolerance was apparent. However, increased flowering potential in plants from North American P. lanceolata populations was observed. As increased flowering potential was not lost, even after severe cotyledon damage, the manifestation of phenotypic plasticity in weeds at maturity may nonetheless still be shaped by plasticity in the ability to tolerate herbivory during seedling establishment.
0106. The beetles of St. Lucia, Lesser Antilles (Insecta: Coleoptera): diversity and distributions

The published beetle fauna of the island of St. Lucia is summarized. It contains 135 genera, and 175 species in 25 families. Four species are accidentally introduced by human activities. Twenty three species are endemic (restricted) to the island. Twenty seven species on St. Lucia are shared only with other islands of the Lesser Antilles, and 22 species are widespread Antilles endemics. The remaining 56.6% of the fauna is otherwise mostly one which is widely distributed in the Antilles and the Neotropics. This suggests that it is mostly an immigrant fauna originating in the continental Neotropics. Undoubtedly, the actual numbers of species on St. Lucia are many times higher than now reported and may originally have been as high as around 1400 species. Of the St. Lucia species known to occur on other islands, the largest numbers are shared with Guadeloupe (102), St. Vincent (79), and Martinique (55).
Adaptive non‐singular fast terminal sliding mode control for multi‐agent systems with unknown non‐linear dynamics

This study considers the finite time consensus tracking problems for second-order non-linear multi-agent system with the unknown dynamics. Firstly, the radial basis function neural networks are utilised to approximate the lumped unknown dynamic model. And then, to achieve the finite-time consensus tracking, a distributed non-singular fast terminal sliding mode control strategy is designed which can speed up the convergence of the multi-agent system. Moreover, the consistency under the proposed control strategy is theoretically analysed and the upper bound of setting time is explicitly obtained. Finally, two simulation examples are provided.
Dérégulations épigénétiques induites par la protéine fusion BRD4-NUT et caractérisation de la proteine NUT au cours de la spermatogenèse et dans les cancers

Il apparait de nos jours evident que les cancers ne peuvent se reduire uniquement a des aberrations genetiques, et qu'un nouveau parametre est a prendre en consideration, l'epigenetique. Au cours de ma these je me suis efforce de caracteriser la proteine fusion BRD4-NUT. Cette proteine resulte d'une translocation t(15;19) observee dans les carcinomes de la ligne mediane (NMC), extremement agressifs et letaux. La proteine BRD4 possede un double bromodomaine capable de s'associer a la chromatine acetylee, et recrute divers facteurs sur la chromatine. NUT est une proteine de fonction inconnue exprimee exclusivement au cours de la spermatogenese. J'ai pu demontrer que la proteine fusion BRD4-NUT etait suffisante pour induire la tumorigenese, par un mecanisme de sequestration de la proteine histone acetyltransferase (HAT) CBP/p300. NUT interagit avec CBP/p300 et suractive son activite d'acetylation, creant des foci hyperacetyles de chromatine. BRD4-NUT empeche ainsi CBP/p300 d'aller co-activer la transcription de nombreux genes, et bloque notamment la reponse apoptotique p53-dependante. Une inhibition de BRD4-NUT – par siRNA, mutation des bromodomaines ou deregulation de l'acetylation des foci par des inhibiteurs des histones deacetylases (HDAC) – reenclenche la voie d'apoptose et la mort de ces cellules tumorales. Cette etude est un exemple precis de l'impact qu'une deregulation epigenetique peut avoir sur l'homeostasie cellulaire et son mecanisme d'induction de la tumorigenese. Je me suis egalement interesse a caracteriser la proteine NUT lors de son contexte physiologique, la spermatogenese, ou lors de son expression illegitime dans des lignees tumorales sans fusion avec BRD4. La proteine NUT est exprimee au niveau des stades de maturation des cellules germinales spermatides, et pourrait participer au remodelage du genome et a l'etablissement de l'epigenome final du spermatozoide. Nut semble egalement conferer un avantage proliferatif lors de son expression anormale dans au moins trois lignees cellulaires, U2OS, A549 et A7R5. Ainsi, la proteine NUT, seule ou fusionnee avec BRD4, est un facteur Cancer/Testiculaire capable d'influer negativement sur l'homeostasie des cellules somatiques dans lesquelles ses fonctions, normalement restreintes a la spermatogenese, participent a la tumorigenese.
Targeted Disruption of Tumor-Derived Chemokine Synthesis and Reversal of Tumor-Induced Immune Suppression

Abstract : Chemokines play a pivotal role in the maturation of the immune system, and in the initiation, and maintenance of an immune response. Because of their key role in the immune response, the aberrant expression of chemokines can have a profound effect on the ability of T cells to respond to antigen. We have found that several breast cancer cell lines produced chemokines capable of recruiting T cells. However, instead of increasing anti-tumor immunity, the tumor-derived chemokines may have prevented an effective immune response by desensitizing T-cell chemokine receptors. Our hypothesis is that disrupting the synthesis of tumor-derived chemokines (using anti-sense technology) will remove tumor-induced immune suppression and enhance the immunogenicity of the tumor. In order to test this hypothesis we have generated stable clones that lack MCP-l and RANTES production compared to the parental tumor cell line. Using these tumors we will determine whether the T cells are better able to elicit an anti-tumor immune response by comparing the immunogenicity of the tumors that do and do not express chemokines. These tumor cells will be evaluated by immunization/challenge experiments and by the ability to generate tumor-specific T cells in vaccine draining lymph nodes.
A 40-year High Arctic climatological dataset of the Polish Polar Station Hornsund (SW Spitsbergen, Svalbard)

Abstract. The article presents the climatological dataset from the Polish Polar Station Hornsund located in the southwest part of Spitsbergen – the biggest island of the Svalbard archipelago. Due to a general lack of long-term in situ measurements and observations, the High Arctic remains one of the largest climate-data-deficient regions on the Earth. Therefore, the described time series of observations in this paper are of unique value. To draw conclusions on the climatic changes in the Arctic, it is necessary to analyse and compare the long-term series of continuous, in situ observations from different locations, rather than relying on the climatic simulations only. In recent decades, rapid environmental changes occurring in the Atlantic sector of the Arctic are reflected in the data series collected by the operational monitoring conducted at the Hornsund station. We demonstrate the results of the 40-year-long series of observations. Climatological mean values or totals are given, and we also examined the variability of meteorological variables at monthly and annual scale using the modified Mann–Kendall test for trend and Sen's method. The relevant daily, monthly, and annual data are provided on the PANGAEA repository ( https://doi.org/10.1594/PANGAEA.909042 , Wawrzyniak and Osuch, 2019).
Integration in Spinal Neuronal Systems

The sections in this article are: 1 Methodological Considerations 1.1 Selective Stimulation of Primary Afferents 1.2 Stimulation of Central Motor Systems 1.3 Methods for Investigation of Convergence at Interneuronal Level 2 Spinal Neuronal Circuits Used in Common by Segmental Afferents and Supraspinal Motor Centers 2.1 Recurrent Inhibition 2.2 Pathways From Ia-Afferents and Their Control by γ-Motoneurons 2.3 Reflex Pathways From Group Ib Tendon Organ Afferents 2.4 Reflex Pathways From Cutaneous and Joint Afferents and From Groups II and III Muscle Afferents 2.5 Propriospinal Neurons 2.6 Presynaptic Inhibition of Transmission From Primary Afferents 3 Reticulospinal Inhibition of Segmental Reflex Transmission 3.1 Dorsal Reticulospinal System 3.2 Ventral Reticulospinal Pathways 3.3 Monoaminergic Reticulospinal Pathways 3.4 Decerebrate Preparation 4 Direct Projections of Descending Pathways to α-Motoneurons 5 Ascending Pathways that Monitor Segmental Interneuronal Activity 5.1 Evidence That Ascending FRA Pathways Monitor Activity in Interneurons of Reflex Pathways 5.2 Information Via Ascending Collaterals of Interneurons 5.3 Ventral Flexor Reflex Tracts 5.4 Ventral Spinocerebellar Tract 6 General Summary and Epilogue 6.1 General Summary 6.2 Epilogue
A Novel Extended Impedance-Power Droop for Accurate Active and Reactive Power Sharing in a Multi-Bus Microgrid With Complex Impedances

This paper addresses a novel and flexible control algorithm based on complex virtual impedance for improvement of power sharing in a multi-bus microgrid with complex impedance of lines. In the proposed method, first, the Extended Impedance-Power droop equations are derived. Using nonlinear droop equations, equivalent resistance and inductance of each DG unit are obtained by active and reactive power, separately. Then, an appropriate algorithm is employed to implement Impedance-Power droop to manage the virtual impedances adaptively. The proposed algorithm can optimally share both active and reactive power, even when the structure is changed without any knowledge of microgrid parameters and high-bandwidth communication links. The parameters of the proposed controller are designed based on the nominal power of inverters. Moreover, the stability margin of the system is analyzed. Finally, the feasibility of the proposed control scheme is confirmed via simulations and experiments.
Outcome of a public consultation on the draft risk assessment of chlorinated paraffins in feed and food

The European Food Safety Authority (EFSA) carried out a public consultation to receive input from interested parties on the draft scientific opinion on the risk assessment of chlorinated paraffins in feed and food. This draft scientific opinion was prepared by the EFSA Panel on Contaminants in the Food Chain (CONTAM Panel), supported by the Working Group on Chlorinated Paraffins in food and feed. The draft opinion was endorsed by the CONTAM Panel for public consultation by written procedure on 31 July 2019. The written public consultation was open from 6 August until 17 September 2019. EFSA received comments from 11 different interested parties. EFSA and its CONTAM Panel wish to thank all stakeholders for their contributions. The present report contains the comments received and explains the way they have been considered for finalisation of the opinion. The opinion was adopted at the CONTAM Plenary meeting on 17 December 2019 and published in the EFSA Journal. Abstract Abstract-Lines 24 to 26: As brought forward in the POPs meeting of 09.09. 2019 and supported by the Netherlands, I would propose to adapt the wording of the sentence beginning with " The panel concluded, that the MOEs do not indicate a health concern. " as follows: " The Panel concluded that the MoEs do not indicate a health concern. Although EFSA noted uncertainties of Scientific Opinion, overall conclusion should be re-phrased more cautiously as MoE is usually considered as a risk management tool. Abstract Although EFSA quite extensively elaborates restrictions and limitations later on, line 17/18 present the reader two definitive BMDL10 values without any caveats. Based on the data and age/ reliability of the toxicological studies used, we propose to signal clearly that these BMDL10 values are more of a tentative nature – e.g. as “The Panel selected as reference points a provisional BMDL10 […] for some SCCPs and MCCPs, respectively. ” The second amendment is proposed as the toxicological studies only covered a very small segment of SCCPs or MCCPs, respectively, and the overall toxicological effects from other, not tested CPs were apparently derived from the available data by cross-reading different studies [p. 175-176, ll. 4898-4903]. Furthermore, we propose that the sentence “The Panel concluded that the MOEs do not indicate a health concern,…” might be amended as follows: “the Panel concluded that the MOEs derived for ‘fish meat’ do not presently indicate a health concern for this food group ,…”. This way the caveats to this conclusion briefly mentioned in the second part of the sentence would become much clearer and misunderstandings as to the scope of the conclusion on a lack of health concern could be avoided more easily. Summary and other Opinion the and uncertainties
A 20-YR STUDY DOCUMENTING THE RELATIONSHIP BETWEEN TURTLE DECLINE AND HUMAN RECREATION'

This study documents the detrimental effects of human recreation on the North American wood turtle (Clemmys insculpta) in Connecticut. We chronicled the dy- namics of two allopatric wood turtle populations in a protected southern New England wildlife reserve for 20 yr (1974-1993). Both wood turtle populations were reproductively isolated from one another, physically separated -100 yr ago when a 1.5 km long human- made pond was constructed. We conducted a mark-and-recapture study on a 1000-ha section restricted, and the quality of the air and water were constant. The wood turtle populations remained stable when people were denied access to the property. When this area was opened to human recreation (hiking, fishing) the two discrete wood turtle populations declined steadily; the total number of turtles in both populations declined by 100% in 10 yr. As wilderness areas become mixed-use recreation areas, wood turtle populations may suffer. We conclude that without proper management, the increasing recreational use of parks, reservoirs, and wildlife reserves will adversely affect the long-term survival of the North American wood turtle.
Internal solitary waves from L-band SAR over the Argentine inner Patagonian shelf

ABSTRACT Internal waves represent an important mechanism of energy exchange influencing primary production through the turbulent transport of nutrients and changes in the intensity of light available for photosynthesis. Internal solitary waves (internal solitons) appear in packages and retain their shape and speed even after interacting with other internal waves. We detected solitons in the inner Patagonian shelf with the active L-band microwave satellite sensor (ALOS-PALSAR). Packages found in the satellite images were digitized. Generation mechanisms and propagation speeds were assessed using historical CTD profiles near the detected waves, assuming linear theory and atwo-layer vertical structure. The estimated propagation speeds of the waves ranged from 0.5 to 0.7m s−1. The generation regimes of waves originated at asill near the coast were classified as subcritical or near-critical according to the Froude number. We hypothesize that at this site, the generation mechanism starts leeward from the sill (lee wave mechanism), after the relaxation of the tidal current. Generation mechanisms of waves detected elsewhere over the shelf are not so obvious. More images are necessary to better determine the wave generation site. We will continue the analysis with L-band images aboard the SAOCOM 1A (CONAE), put in orbit in October 2018.
A new red -fleshed kiwifruit cultivar ‘Chuhong’

‘Chuhong’ is a red-fleshed kiwifruit cultivar selected from Actinidia chinensis var. rufopulpa grown in the wild.The fruit has beautiful red flesh color around the central core. It also has high soluble solids content and good taste. The plantsgrow well in both high and low altitude conditions, and are precocious and productive. The fruit matures in early September, and has reasonably good storage quality. There is a very positive response from customers according to preliminary marketing tests.
“Methodology Comparative Analysis” in the Solar Decathlon Competition: A Proposed Housing Model based on a Prefabricated Structural System

The construction sector, by direct or indirect actions, consumes more than 40% of the global energy produced and is responsible for 30% of CO2 emissions. It is a need of the construction industry to transform its practices and processes by proposing systems of lower demand to the environment. In this sense, closed prefabrication and industrialization as a constructive process could be the key to seek savings and efficiency from its origin to the end of life of buildings. In this context, this article presents a methodological proposal of quantitative, qualitative and comparative analysis of the structural systems of eight prototypes presented in the “Solar Decathlon” contest in its North-American and Latin-American editions (both of them in 2015) and the European edition (in 2014). This methodology deduces the characteristics of a structural system of lower environmental demand and the characteristics of these constructive processes, in favor of a new paradigm of sustainability and to be applied in innovative systems of new housing models.
Simultaneous Tracking and Elasticity Parameter Estimation of Deformable Objects

In this paper, we propose a novel method to simultaneously track the deformation of soft objects and estimate their elasticity parameters. The tracking of the deformable object is performed by combining the visual information captured by a RGB-D sensor with interactive Finite Element Method simulations of the object. The visual information is more particularly used to distort the simulated object. In parallel, the elasticity parameter estimation minimizes the error between the tracked object and a simulated object deformed by the forces that are measured using a force sensor. Once the elasticity parameters are estimated, our tracking algorithm can be used to estimate the deformation forces applied to an object without the use of a force sensor. We validated our method on several soft objects with different shape complexities. Our evaluations show the ability of our method to estimate the elasticity parameters as well as its use to estimate the forces applied to a deformable object without any force sensor. These results open novel perspectives to better track and control deformable objects during robotic manipulations.