Miracle-dz/UniFAR-FTUs huggingface dataset:
Applicability of electro-osmotic flow for the analysis of the surface zeta potential

The analysis of the surface zeta potential (SZP) opens up new possibilities in the characterization of various materials used for scientific or industrial applications. It provides at the same time insight into the material surface chemistry and elucidates the interactions with charged species in the aqueous test solution. For this purpose, an accurate, reliable and repeatable analysis of the SZP is the key factor. This work focuses on a detailed and systematic comparison of two electrokinetic techniques, i.e. the mapping of the electro-osmotic flow (EOF) and the measurement of the streaming potential (SP), for the surface zeta potential (SZP) determination of several materials with varying properties. Both techniques have advantages as well as drawbacks. The applicability of latex polymer material and inorganic tracer particles at varying ionic strength, the interaction between oppositely charged tracer particles and solid surfaces, the assessment of the pH dependence of the SZP and the isoelectric point (IEP), and the effects of sample porosity and conductance have been investigated. Although in some cases the EOF method gives a SZP similar to the streaming potential measurement, especially when the tracer particle exhibits the same charge as the solid surface, it was revealed that reliable results were only obtained with the streaming potential and streaming current method. Several obstacles such as elevated conductivity at higher ionic strength, the applied voltage for the EM measurement, and the nature of tracer particles lower the accuracy and reliability of the SZP determined by the EOF method. It was shown that the EOF method is not applicable to oppositely charged surface and tracer particles and also limited to low salinity conditions especially when using polymeric tracer particles. Although the EOF method does not require the formation of a capillary flow channel, it disables a non-destructive SZP of fragile or valuable samples, such as QCM-D sensors, in comparison to the SP approach.
Accurate 3-D radiative transfer simulation of spectral solar irradiance during the total solar eclipse of 21 August 2017

Abstract. We calculate the variation of spectral solar irradiance in the umbral shadow of the total solar eclipse of 21 August 2017 and compare it to observations. Starting from the Sun's and Moon's positions, we derive a realistic profile of the lunar shadow at the top of the atmosphere, including the effect of solar limb darkening. Subsequently, the Monte Carlo model MYSTIC (Monte Carlo code for the phYSically correct Tracing of photons In Cloudy atmospheres) is used to simulate the transfer of solar radiation through the Earth's atmosphere. Among the effects taken into account are the atmospheric state (pressure, temperature), concentrations of major gas constituents and the curvature of the Earth, as well as the reflectance and elevation of the surrounding area. We apply the model to the total solar eclipse on 21 August 2017 at a position located in Oregon, USA, where irradiance observations were performed for wavelengths between 306 and 1020 nm. The influence of the surface reflectance, the ozone profile, the mountains surrounding the observer and aerosol is investigated. An increased sensitivity during totality is found for the reflectance, aerosol and topography, compared to non-eclipse conditions. During the eclipse, the irradiance at the surface not only depends on the total ozone column (TOC) but also on the vertical ozone distribution, which in general complicates derivations of the TOC from spectral surface irradiance. The findings are related to an analysis of the prevailing photon path and its difference compared to non-eclipse conditions. Using the most realistic estimate for each parameter, the model is compared to the irradiance observations. During totality, the relative difference between model and observations is less than 10 % in the spectral range from 400 to 1020 nm. Slightly larger deviations occur in the ultraviolet range below 400 and at 665 nm.
Improving Human Papillomavirus Vaccination Uptake in College Students: A Socioecological Perspective

ABSTRACT Background: Human papillomavirus (HPV) vaccination rates remain relatively low, despite new recommendations found in Healthy People 2020. Purpose: The purpose of this study was to determine vaccination rates, identify factors that influenced initiation/continuance of HPV vaccine series, and identify levels of influence for HPV health behaviors in college students. Methods: Two hundred first- and second-year college students completed an online survey to determine HPV knowledge, vaccine perceptions/behaviors, and Health Education sources. The socioecological model provided a framework to examine students’ responses regarding sources of influence for current and future health behaviors and vaccine uptake. Results: Forty-eight percent reported receiving the HPV vaccine, yet only 7 out of 36 males had been vaccinated. Students indicated being most influenced by community/organizational factors such as physicians (79.5%), mother (75%), and father (36%). Discussion: Gender and ethnicity were found to be predictive of vaccine uptake, whereas HPV knowledge did not independently contribute to vaccination rates. Students reported primarily preferring to hear about sexual health issues from school classes or lectures, a health care provider, media sources, or family members. Translation to Health Education Practice: Results highlight the importance of moving beyond HPV intervention strategies that function only to improve knowledge and include components that address various levels of influence.
Isparta ve çevresinde klopidogrel direncinin araştırılması

Giris ve amac: Akut koroner sendrom (AKS) ile basvuran ve/veya stent uygulanan hastalarda klopidogrel tedavisi gunumuzde standart tedavidir. Bununla beraber klopidogrel tedavisine yanitsizlik olumsuz sonuclarla iliskili olmasi nedeni ile gunumuzde onemli bir sorundur. Antitrombositer ilaclarin etkinligini olcmek icin kullanilan trombosit fonksiyon testleri cogu kez pahali, zaman alici ve ulasilmasi zor testlerdir. Klopidogrel direncini saptamak icin pratik, kolay uygulanabilinir, ucuz ve guvenilir parametrelere ihtiyac vardir. Materyal-Metot: Akut Koroner Sendrom tanisi ile klopidogrel kullanan 531 hasta calismaya alindi. Alinan kan orneklerinde MEA (multiple electrod aggregometry) ile calisildi. Sonuclar egri altinda kalan alan (AUC) cinsiden verildi. AUC > 470 olmasi klopidogrel direci, olarak yorumlandi. Bulgular: Toplamda 65 (% 12,2) hastada klopidogrel direnci saptandi. Kadin hastalarda klopidogrel direnci anlamli olarak fazlaydi (P= 0,005). Risk faktorlerine bakildiginda ise hiperlipidemik ve diyabetik hastalarda klopidogrel direnci daha fazla gorulurken, sigara icenlerde direnc daha az gorulmekteydi (p= 0,016, p< 0,001, p= 0,046). Klopidogrel direnci olan hastalarda kalsiyum seviyesi, trombosit sayisi ve vucut kitle indeksi daha yuksek bulundu. Sonuc: Bu calisma, vucut kitle indeksi, diyabet, hiperlipidemi, kadin cinsiyet’in klopidogrel direnci acisindan bir risk faktoru olabilecegini ortaya koymustur.
Hipertensão pulmonar tromboembólica crônica: tratamento medicamentoso dos pacientes não cirúrgicos Chronic thromboembolic pulmonary hypertension: medication treatment of non- surgical patients

The chronic thromboembolic pulmonary hypertension (CTEPH) is a condition in which the increase of pulmonary vascular resistance is due to an obstruction of the vascular bed that may be partially recanalized by organized thrombus, whose severity depends on the extent of this blockage. Another mechanism involves endothelial dysfunction and arteriolar remodeling present in the pulmonary vascular bed not obstructed, in a similar fashion to that seen in idiopathic pulmonary arterial hypertension. The ideal treatment is the surgical removal of thrombus through the pulmonary thromboendarterectomy (PEA). However, a significant proportion of patients is considered inoperable due to the predominantly peripheral localization of thrombi - that become inaccessible to surgical removal - due to the presence of significant comorbidities - that significantly increase the risk of surgery - or by unevenness of pulmo nary vascular resistance and degree of obstruction observed. Moreover, some patients have persistent pulmonary hypertension after PEA. In these situations, it is that lies the context of the indication of treatment with pulmonary vasodilators in CTEPH.
What and where is an octopus’s mind?

: It is gratifying to see the thorough discussion of whether octopuses have a mind, though perhaps a mind that is different from those of “ higher ” vertebrates. It stimulates us to look at the welfare of these animals and challenges us to find better ways to test mindfulness and cognition across animals with widely differing natural histories and sensory and motor capacities.
Trastuzumab treatment and the risk of central nervous system (CNS) metastases

1018 Background: In the era of trastuzumab, HER2-positive breast cancer confers an increased risk of central nervous system (CNS) metastases. While several studies have examined CNS metastases in trastuzumab-treated patients, data are sparse regarding CNS metastases in trastuzumab-naive HER2-positive patients. We evaluated time to CNS metastasis, death, and death subsequent to brain metastasis in relation to trastuzumab treatment. Methods: The study population included 750 patients diagnosed with HER2-positive metastatic breast cancer (HER2+ MBC) between June 1977 and January 2006. The association between trastuzumab treatment and the outcomes of time to CNS metastasis and time to death following CNS metastasis were determined using Cox proportional hazards models that included trastuzumab treatment as a time-dependent covariate. Multivariable Cox proportional hazards models were fit to determine the association between trastuzumab treatment and outcomes after adjustment for known prognostic factors. Pati.
PMFF: Development of a Physics-based Molecular Force Field for Protein Simulation and Ligand Docking

The physics-based molecular force field (PMFF) was developed by integrating a set of potential energy functions in which each term in an intermolecular potential energy function is derived based on experimental values, such as the dipole moments, lattice energy, proton transfer energy, and X-ray crystal structures. The term, “physics-based,” is used to emphasize the idea that the experimental observables that are considered to be the most relevant to each term are used for the parameterization rather than parameterizing all observables together against the target value. PMFF uses MM3 intramolecular potential energy terms to describe intramolecular interactions and includes an implicit solvation model specifically developed for the PMFF. We evaluated the PMFF in three ways. We concluded that the PMFF provides reliable information based on the structure in a biological system and interprets the biological phenomena accurately by providing more accurate evidence of the biological phenomena.
Updates from the 2016 American Society of Hematology annual meeting: practice-changing studies in untreated follicular lymphoma

The 2016 annual meeting of the American Society of Hematology took place in San Diego, California, 3–6 December. At the meeting, results from key studies on the first-line treatment of follicular lymphoma were presented. Of those studies, key oral presentations included two analyzing data from the gallium study, which evaluated the efficacy and safety of obinutuzumab plus chemotherapy (G-chemo) compared with rituximab plus chemotherapy (R-chemo), followed, in responding patients with follicular lymphoma, by obinutuzumab or rituximab maintenance; results from the sabrina study, which evaluated the efficacy and safety of subcutaneous compared with intravenous rituximab; results of a cost-effectiveness analysis of first-line treatment with bendamustine and rituximab from a Canadian perspective; and results from the SAKK 35/10 study, which evaluated the safety and efficacy of rituximab plus lenalidomide compared with rituximab monotherapy. Our meeting report describes the foregoing studies and includes interviews with the Canadian investigators, plus commentaries by those investigators about the potential impact on Canadian practice.
Intracranial Hematoma in Herpes Simplex Encephalitis: A Rare Complication

A previously healthy man aged 27 years was admitted to our hospital with a 2-day history of headache, confusion, and fever. The initial neurologic examination revealed impaired consciousness without seizures or focal neurologic deficits. Cerebrospinal fluid (CSF) analysis showed white blood cells 270/mm3 (87% lymphocytes, 13% neutrophils), protein level 132,6 mg/dL, and glucose 53 mg/dL (the synchronous serum value was 102 mg/dL). Other blood cell counts and the results of routine biochemical analysis were normal. CSF and blood cultures were negative. Electroencephalography showed right temporal focal slowing. CSF samples were positive for herpes simplex virus (HSV) 1 DNA in polymerase chain reaction, which confirmed the diagnosis of HSV1 meningoencephalitis and antivirus treatment was started. The patient received intravenous acyclovir (30 mg/kg/day for 21 days) and dexamethasone (16 mg/day for 16 days). Brain computerized tomography (CT) performed on admission was normal (Figure 1). Brain magnetic resonance imaging performed on admission showed increased signal intensity in right temporal, inferior frontal, insular, and left medial temporal areas (Figure 2). Brain CT scan on day 2 showed a hematoma in the right medial temporal lobe with mass effect (Figure 3). The patient had no secondary clinical deterioration. Magnetic resonance angiography showed no aneurysm or vascular malformation. He remained asymptomatic on subsequent clinical follow-up. Herpes simplex encephalitis (HSE) complicated by intracerebral hematoma is very unusual. It has been suggested that the rupture of small vessels affected by vasculitis causes secondary bleeding (1). Intracerebral hematoma may occur on admission or during hospitalization and even early treatment with acyclovir (2).
The complete mitochondrial genome of Siberian roe deer (Capreolus pygargus bedfordi) and its phylogenetic analysis

Abstract Due to the multiple causes, the population of roe deer has declined significantly. In this study, we analyzed the complete mitogenome of Capreolus pygargus bedfordi, whose genome was 16,357 bp long. There were 13 protein-coding genes (PCG), two ribosomal RNA genes (12S rRNA and 16S rRNA), 22 transfer RNA genes, and one control region. Nine PCGs started with ATG, while NAD2, NAD3, and NAD5 genes commenced with ATA, and ND4L began with GTG. ND6 and eight tRNA genes were encoded on the L-strand. These results provide newer molecular information, which contribute to its molecular and phylogenetic studies, and genetic diversity conservation.
Auxin-dependent alleviation of oxidative stress and growth promotion of Scenedesmus obliquus C1S by Azospirillum brasilense

There is currently an increasing interest in the use of microalgae for wastewater treatment and the use of its biomass as a feedstock for biofuels. Both of these applications are often performed more efficiently by microalgal-bacteria consortia. However, the mechanisms that account for the stability and robustness of this kind of interactions are poorly understood. In this study, we confirmed the growth promotion activity of the plant growth-promoting bacterium Azospirillum brasilense Sp245 on the microalgae Scenedesmus obliquus C1S. We show that this activity is critically dependent on bacterial indole-3 acetic acid (IAA) production, which results in a decrease in algal reactive oxygen species (ROS) levels, higher cell densities and ameliorates algal cells bleaching after nitrogen deprivation. We also show a close inter-species interaction between both partners and an active expression of the bacterial ipdC gene involved in production of IAA when co-cultivated. This study extends the current knowledge of the mechanisms underlying bacteria-microalgae consortia to improve their technological applications and to better understand ecological relationships in the environment.
System Design and Power Flow of Stationary Energy Storage Systems

Demographic growth, the pursuit of better living conditions, and the development of digital technologies have caused an increasing demand for energy worldwide. The change from fossil fuels to renewable energy, as a key factor in solving the difficult balance between the growth of energy demand and the necessity to reduce greenhouse gas emissions, brings with it new challenges. Decentralised energy systems are necessary to manage the volatile and distributed energy generation. In conjunction with the increasing penetration of fluctuating renewable energies, grids have to evolve and become smarter to accommodate the bi-directional flow of energy and data. Storage systems contribute to a better integration of intermittent renewable energies, as well as the optimisation of existing generation, transmission, and distribution assets. They can ensure that electricity supply and demand are always balanced, which is of importance to guarantee security of supply. The main advantage of storage systems is their modularity and scalability. In addition, the global energy transition is enabling electromobility. Since 2013, the BMW Group has been offering the BMW i3 worldwide. Due to the growing stationary market, even more automobile manufacturers are recognising the potential to use the lithium-ion batteries installed in the electric vehicles for a second application. This thesis examines the use of automotive batteries in the stationary field. First, an overview of the energy market and the stationary and automotive fields will provide information about the background. The work is structured in three parts. The first part analyses the main stationary applications, their characteristics and the influence on different markets. The second part focuses on the system design. The electric vehicle battery and the required power electronic components are examined on the basis of their quality in respect to efficiency, size, volume, and weight. Based on these components, three system topologies are introduced and compared. Furthermore, multi-battery systems are designed with a combinatorial approach. In the last part, the power distribution in these system topologies, especially in the case of heterogenous systems, is investigated. As one of the most common stationary applications, frequency regulation, is tested on two real energy storage systems, which consist of the combination of BMW i3 batteries, DC/DC converters, and DC/AC inverters. Improvements of operation objectives such as performance, efficiency, and service life can be achieved with the use of control strategies to distribute the power in a profitable way.
Tutela judicial efectiva de las personas con discapacidad intelectual desde el Control de Convencionalidad

In this article, an analysis of the constitutional right to effective judicial protection of persons with intellectual disabilities arising in Ecuador is carried out, relating the research problem with the right to access to justice and due process in guaranteeing the right to defense from the perspective of the control of conventionality of the protection of persons with disabilities. Hence, the objective is to examine from a theoretical perspective the procedural budgets related to legal capacity, exercise capacity, procedural capacity, interdiction, curatorship and its relationship with the effective judicial protection of people with intellectual disabilities. Methodologically, qualitative research is proposed, which based on synthetic-analytical and inductive-deductive methods has allowed us to conclude in the analysis the need to establish a conventional interpretation that guarantees access to justice for these people.
Genetic Diversity Among Three Cultivars Of Peanut (Arachis hypogaea L.) Based On Rapd Markers

Peanut (Arachis hypogea) is a typical plant species of tropical regions that has high economic value. The plantation is widely spread over many areas and the production is being pushed to meet the increasing demand. Peanut breeding program is aimed to improve genetic quality, mainly with resepct of production and thus information on genetic diversity is necessary as a basis for consideration in breeding, management and sustainable utilization. One approach to analyse genetic diversity of peanut is by using molecular markers. Random Amplified Polymorphic DNA (RAPD) is a widely used molecular marker for genetic diversity analysis. Therefore, the aim of this study was to assess genetic diversity of peanut cultivars, i.e. Jerapah, Kancil, and Hypoma 2, based on RAPD markers. The study was conducted in a survey method, in which three individuals of each cultivar were analyzed using PCR-RAPD technique employing twelve primers, i.e. OPA-1, OPA-2, OPA-9, OPA-13, OPB-2, OPB-3, OPB-4, OPB-5, OPB-7, OPB-11, OPB-12 and OPJ-07. Data analysis based on morphological data is also included. Molecular analysis revealed that only 7.55% polymorphic band was obtained, while most of the bands were monomorphic, indicating very low variation among the cultivars. The phenogram that constructed based on literature showed that Kancil was closer to Jerapah cultivar, while RAPD-based dendogram showed that Hypoma 2 was closer to Kancil cultivar.
Complete Haplotype Determination 1 and Single-Chromosome Analysis 2

Haplotype phase represents the collective genetic variation between homologous 9 chromosomes and is an essential feature of non-haploid genomes. Although shotgun sequencing 10 can reveal genotypes at variant sites, it cannot resolve linkage between variant genotypes on each 11 chromosome as most sequencing fragments ( ≲ 1kb) span at most one variant site ( ∼ 1 per 1.5 kb in 12 human genomes). Long-range sequencing can generate variant linkage information, but whether 13 such information can determine whole-chromosome haplotype phase remains unclear. Here we 14 describe a general framework for haplotype inference from variant linkage data using a 15 one-dimensional spin model. Building on this model, we design and implement algorithms that can 16 determine complete chromosomal haplotypes of diploid human genomes using 60 × linked-reads 17 sequencing in combination with 60 × Hi-C sequencing. The computationally inferred haplotypes 18 show high completeness ( > 98%) and accuracy ( > 99%) when compared to reference haplotypes 19 determined from sequencing of single chromosomes. We further present examples of 20 single-chromosome analysis enabled by whole chromosome haplotype information. 21 rithms for solving the minimization problem by simple steepest-descent methods and a software 85 package that performs both linkage extraction and haplotype inference. We perform haplotype 86 inference on two genomes and benchmark the performance against reference haplotype data 87 determined from single-chromosome sequencing. The computationally inferred haplotypes contain 88 no long-range switching errors and can resolve the haplotype phase of >98% of all heterozygous 89 variants with >99% accuracy. In particular, our computational method simultaneously performs 90 haplotype inference and false variant ﬁltration based on haplotype-speciﬁc linkage, thus providing 91 a simple solution for variant detection and phasing. Finally, we describe two applications of whole- 92 chromosome haplotype information for resolving structural alterations of single chromosomes. The 93