Miracle-dz/UniFAR-FTUs huggingface dataset:
Nomogram Predicts the Role of Contralateral Prophylactic Mastectomy in Male Patients With Unilateral Breast Cancer Based on SEER Database: A Competing Risk Analysis

Background Contralateral prophylactic mastectomy (CPM) in female breast cancer (FBC) is supported by multiple clinical studies and consensus guidelines, but knowledge of preventive contralateral mastectomy in male breast cancer (MaBC) is very limited and its benefits are still controversial. Methods A retrospective cohort study was enrolled with 4,405 MaBC patients who underwent unilateral mastectomy (UM) or CPM from the Surveillance, Epidemiology, and End Results (SEER) database from 1998 to 2015. A nomogram was built based on the corresponding parameters by competing risks regression to predict the 3-year, 5-year, and 8-year probabilities of BCSD (breast cancer-specific death). C-index and calibration curves were chosen for validation. Net reclassification index (NRI) and integrated discrimination improvement (IDI) were used to estimate the nomogram’s clinical utility. Results A total of 4,197 patients received UM and 208 patients received CPM, with 63-months median follow-up. In the competing risks regression, six variables (surgery, marital status, T-stage, N-stage, histology, tumor grade) were significantly associated with BCSD. Based on these independent prognosis factors, a nomogram model was constructed. The C-index 0.75 (95%CI: 0.73-0.77) in the training cohort and 0.73 (95%CI: 0.71-0.74) in the internal validation group suggested robustness of the model. In addition, the calibration curves exhibited favorably. The NRI values (training cohort: 0.54 for 3-year, 0.55 for 5-year, and 0.49 for 8-year BCSD prediction; validation cohort: 0.51 for 3-year, 0.45 for 5-year, and 0.33 for 8-year BCSD prediction) and IDI values (training cohort: 0.02 for 3-year, 0.03 for 5-year, and 0.04 for 8-year BCSD prediction; validation cohort: 0.02 for 3-year, 0.04 for 5-year, and 0.04 for 8-year BCSD prediction) indicated that the model performed better than the AJCC criteria-based tumor staging alone. Conclusions The administration of CPM was associated with the decrease in risk of BCSD in patients with MaBC. The nomogram could provide a precise and personalized prediction of the cumulative risk in patients with MaBC after CPM.
Multinode Component Carrier Management: Multiconnectivity in 5G

From its conception, 5G has been designed to support a wide variety of service types, ranging from enhanced mobile broadband (eMBB) to ultrareliable low-latency communications (URLLC). To overcome the disparity of their requirements, a number of radio resource management (RRM) solutions have been proposed, among which multiconnectivity (MC) may be highlighted: that is, the aggregation of radio resources in the shape of component carriers (CCs) from several base stations (BSs). MC allows a number of benefits to be achieved, from increased reliability, due to multilink diversity, to throughput enhancements, due to the usage of additional radio resources and load balance among the involved BSs. This article proposes a novel RRM mechanism to jointly manage user equipment (UE)-BS association rules and CC selection, according to network operators' policies, defined over a variety of performance indicators. Simulations show that, in a scenario of load imbalance, the proposed mechanism allows the UE throughput to be increased while improving the network efficiency by means of a proper inter-CC and inter-BS load balance when compared to traditional received power-based schemes for CC management applied in an MC environment.
Modern warming, medieval and ancient optimums as the result of orbital changes in the Earth-Moon-Sun system

The root cause of modern climate warming is the influence of gravitational forces on the geospheres of our planet, determined by the orbital configuration of the Earth-Moon-Sun system. The annual changes in the position of the total vector of gravitational forces in space visually reflects the movement of the shadow cone of solar eclipses around the globe. The aim and novelty of the study is to identify the relationship between the number of years with four to five polar eclipses (in periods of pessimums, their number reaches 15-17 years, and in periods of optimums – 2-7 years in a century) and glaciation processes, such as the Fernau fluctuation, Late Antique Little Ice Age, or processes of warming and degradation of glaciers in the Roman and Medieval optimums. The research methods were study, generalization of materials, data synthesis, logical and graphical analysis. The anthropogenic causes of modern warming, which will last until the middle of the 22nd century, are secondary. In the second half of the 22nd century, and throughout the entire 24th century, the advance of the alpine glaciers will be associated with the conditions of the climatic pessimum. Solar activity, planetary factors and processes - volcanic activity, current intensity, heat transfer with the World Ocean – can noticeably strengthen or weaken both the manifestation of optimums and pessimums. The results of the study, taking into account other factors, can be used in the retroanalysis of the periods of glaciation in centuries before the Common Era and the prediction of them in the future.
Impact of funding on academic performance: An exploration of two South African universities

Empirical evidence on the relationship between student funding and academic performance is unclear. Some studies have found a positive relationship, some have suggested a negative one, while others maintain that there is no relationship between them. Acknowledging that a range of factors, other than funding, impact on student success, in this paper, we aim to contribute to a small, but emerging, body of literature on the relationship between student funding and academic performance, proxied by the average individual academic mark for the year. We applied descriptive and inferential statistics to a dataset of 29,619 students registered at two South African universities for the 2018 academic year. The results highlight that in an examination of the impact of being funded by the National Student Financial Aid Scheme (NSFAS) in a bivariate context, it is possible to find a negative relationship with performance. However, at an aggregate level and controlling for the impact of other variables, a positive (albeit weak) and statistically significant correlation between being NSFAS funded and average academic performance emerges.
Removal of Congo Red by Acrylic Acid-co-[2-[2- (Benzimidazole) Azo]-3-Methyl-4-Nitro Phenol] Composite from Aqueous Solution by Adsorption process

INTRODUCTION Wastewater from the textile finishing industry can have a strong impact on the aquatic environment because it is discharged in high quantity and may contain many biorecalcitrant contaminants.1 Many dyes used in textile industry are particularly difficult to remove by conventional waste treatment methods since they are stable to light and oxidizing agents and are resistant to aerobic digestion.2 The removal of color from dye–bearing effluents is a major problem because of the difficulty in treating such wastewaters by conventional treatment methods.3 Most dyecontaining effluents from various industrial branches, mainly dye manufacturing, and textile finishing, are discharged into river streams.4 The removal of dyes in an economical fashion remains an essential problem, although recently, a number of successful systems have been evolved using adsorption techniques.5 The aim of this work in to investigate the capability of AA-co-L2H composite for the prevention of toxicity by Congo red in different conditions of temperature and concentration. EXPERIMENTAL
FUNCTIONAL ATTRIBUTES AS ECOLOGICAL PREDICTORS DURING SECONDARY SUCCESSION IN A SEASONAL DECIDUOUS FOREST IN SOUTHERN BRAZIL

ABSTRACT Through the variation of the functional attributes, it is possible to verify the functioning of an ecosystem, both by the species organization as by their responses to the environmental variations. In this sense, the objective of this study was to analyze the ecological strategies of the main tree species by analyzing their functional attributes. PCoA was used to verify which species are acquisitive and conservative; clustering was used to verify the functional attributes by groups; the Pearson’s correlation between the functional attributes and a CWM-RDA analysis was used to verify the environmental variables. Most species were classified as light-demanding climax and having zoochoric dispersion. The species presented phenotypic plasticity as an important ecological strategy in the composition of their functional attributes, especially when related to leaf area and specific leaf area. Most of the species belonged to the acquisitive group. The acquisitive and conservative groups indicate the resilience potential of the tree community and the change processes in ecological succession. There was a strong negative correlation between the leaf attributes, and a positive one with diameter and height, both correlations related to plant growth and development. Of the environmental variables only pH, K, and average elevation, were related to the attributes, indicating that environmental conditions are important for the establishment of the sampled species. Also, it was found that the species composition is linked to several conditions of ecological strategies associated with changes in the environment.
Pedagogy of emergency and vulnerability: testing of a Mental Skill Training protocol

Abstract (in italiano) La ricerca proposta riguarda i filoni di studio della Pedagogia dell'emergenza e della vulnerabilita. Nel 2020, a causa della pandemia, la popolazione mondiale ha potuto provare cosa vuol dire vivere una situazione di emergenza e quanto questa possa aver inciso dal punto di vista pedagogico. In letteratura vi sono molte evidenze che testimoniano come tali situazioni possano essere vissute in modo piu funzionale, se si e in grado di sfruttare le proprie risorse in termini di resilienza e di risposte adattive. Mai come in situazioni come questa la resilienza e l’anti-fragile sono concetti e risorse che assumono grande importanza (Piceci, Cancellara 2020; Taleb, 2013). La resilienza e una struttura multidimensionale (Kumpfer 1999; Mariani, Marcolongo, Melchiori, Peluso Cassese, 2019) e, osservandone le varie componenti, l’equipe di ricerca ha costruito un protocollo di Mental Skill Training, mutuando tecniche e strumenti generalmente applicati in psicologia dello sport. Lo studio sperimentale proposto ha testato un protocollo di Mental Skill Training su un panel di 16 studenti universitari della facolta di psicologia, nell’arco di 6 settimane. L’obiettivo e stato quello di verificare l’impatto di tale protocollo su Autostima e senso di Autoefficacia, nonche su Resilienza e Strategie di coping. Abstract (in inglese) The proposed research concerns the study areas of Emergency and Vulnerability Pedagogy. In 2020, due to the pandemic, the world's population was able to experience what it is like to experience an emergency situation and how much it can impact from an educational point of view. There is ample evidence in the literature that such situations can be experienced in a more functional way if one is able to exploit one's resources in terms of resilience and adaptive responses. Never as in situations like these, resilience and anti-fragile are concepts and resources that assume great importance (Piceci, Cancellara 2020; Taleb, 2013). Resilience is a multidimensional structure (Kumpfer 1999; Mariani, Marcolongo, Melchiori, Peluso Cassese, 2019) and, observing its various components, the research team has built a Mental Skill Training protocol, borrowing techniques and tools generally applied in sports psychology. The proposed experimental study tested a Mental Skill Training protocol on a panel of 16 university students from the Faculty of Psychology, over a period of 6 weeks. The objective was to test how participation in this protocol could affect self-esteem and sense of self-efficacy, as well as Resilience and Coping Strategies.
Genome-wide analysis of AP2/ERF Transcription Factors in sugarcane Saccharum spontaneum L. Reveals Functional Divergence During Drought, Salt Stress and Plant Hormones Treatment

Background: APETALA2/ETHYLENE RESPONSIVE FACTOR (AP2/ERF) transcription factors play important roles in plant growth, development, metabolism, as well as in biotic and abiotic stress responses. However, there are few studies concerning AP2/ERF genes in sugarcane, which is the most critical sugar and energy crop worldwide. Results: A total of 218 AP2/ERF genes were identified in the Saccharum spontaneum genome. Phylogenetic analysis showed that these genes could be divided into four groups, including 43 AP2s, 160 ERFs, and Dehydration-responsive element-binding (DREB) factors, 11 ABI3/VPs (RAV) and 4 Soloist genes. These genes were unevenly distributed on 32 chromosomes. Analysis of the structural of SsAP2/ERF genes showed that 91 SsAP2/ERFs lacked introns. Sugarcane and sorghum have a collinear relationship between 168 SsAP2/ERF genes and sorghum AP2/ERF genes that reflects their similarity. Multiple cis-regulatory elements (CREs) are present in the SsAP2/ERF promoter, and many are related to abiotic stresses, suggesting that SsAP2/ERF activity could contribute to the adaptation of sugarcane crops to environmental changes. The tissue-specific analysis showed spatiotemporal expression of SsAP2/ERF in the stems and leaves of sugarcane at different stages of development. In 10 sugarcane samples, 39 SsAP2/ERFs were not expressed at all, whereas 58 SsAP2/ERFs were expressed in all samples. Quantitative PCR experiments showed that SsERF52 expression was up-regulated under salt stress, but suppressed under drought stress. SsSoloist4 had the most considerable upregulation in response to treatment with the exogenous hormones ABA and GA. Within 3 hours of ABA or PEG6000 treatment, SsSoloist4 expression was up-regulated, indicating that this gene could play a role in ABA and GA-associated drought stress response mechanisms. Analysis of AP2/ERF gene expression patterns under different treatments indicated that SsAP2/ERF genes play an important role in drought and salt stress responses of S. spontaneum. Conclusions: In this study, a total of 218 members of the AP2 / ERF superfamily were identified in sugarcane, and their genetic structure, evolution characteristics, and expression patterns were studied and analyzed. The results of this study provide a foundation for future analyses to elucidate the importance of AP2/ERF transcription factors in the function and molecular breeding of sugarcane.
Outdoor Education and Its Influence on The Successful Involvement of Pupils in The Social Life

One of the main priorities of current educational systems is a strong connection between education provided by schools and the requirements of a successful integration in the social life and work field. This article offers the teachers’ perspective on the various ways in which outdoor learning can be useful in creating teaching-learning situations that prepare pupils to be active citizens and to have smoother integration in the social life and this way, on the labor market. The findings of a brief study among teachers from Arad County is presented. The method that was used is the survey based on a questionnaire. The main instrument that used was the questionnaire, which was based on a number of 12 variables. The quantitative data obtained was processed in the SPSS statistical program. The preliminary results show that even if teachers have some knowledge on the benefits of outdoor education regarding future involvement of pupils in social life, they tend to rarely use it in their educational practice. This happens because of the lack of correct and valid information they have on this type of education, and also because of the misconceptions of parents, who refuse to cooperate regarding this issue. The present study brings and important contribution in this research field, highlighting the values of outdoor education, both theoretically and practically.
Study of Serum Interleukin-17 Level in PatientsiwithiAllergiciRhinitis andiNasaliPolyposis

Rhinitis is aiheterogeneous disordericharacterized by one or more of the following nasalisymptoms: isneezing, iitching, irhinorrhea, and/or nasal congestion. iRhinitis frequently is accompanied byisymptoms involving the eyes, iears, andithroat, including postnasalidrainage. To evaluateithe expressioniof interleukin-17iin patients presentingiwithiallergic rhinitisiand nasalipolyposis. This Aicase-control study was conductedion total of 60 subjects at BenhaiUniversity and BenhaiTeaching Hospitals. They wereidivided into two equaligroups; the casesigroup which included 15 allergicirhinitis case, and 15 nasalipolyposis cases, and theicontrol group whichiincluded 30 healthyisubjects. All cases were subjected toicomplete historyitaking and thorough rhinologicaliexamination. In addition, iserum and tissueiIl-17 were measures for all cases, whereas only theiserum level was measured inicontrols. Expression ofiIL-17 was significantly upregulated iniNP patients and was more severe iniatopic patients. In addition, there wereisignificantly positive correlationsibetweeniIL-17 and clinical and histological features. Our study suggests an important role for IL-17iiniNP. Overall, we hopeithat present study would enable us to obtain a deeper insight into the pathogenesisiofiNP and provide a potential target for the treatment of NP. Based on our study results, increasediIL-17 serumilevels might be considered a marker ofiallergy severity iniallergic rhinitisiand nasalipolyposis patients. This implies that IL-17 mayibe one of theietiologies in the pathogenesis of bothiAR andiNP. Based on these results, we propose that IL-17icontribute to the developmentiof NP and have an impact on clinical severity.
Reversible-Deactivation Radical Polymerization in the Presence of Metallic Copper. A Critical Assessment of the SARA ATRP and SET-LRP Mechanisms

Reversible-deactivation radical polymerization (RDRP) in the presence of Cu0 is a versatile technique that can be used to create well-controlled polymers with complex architectures. Despite the facile nature of the technique, there has been a vigorous debate in the literature as to the mechanism of the reaction. One proposed mechanism, named supplemental activator and reducing agent atom transfer radical polymerization (SARA ATRP), has CuI as the major activator of alkyl halides, Cu0 acting as a supplemental activator, an inner-sphere electron transfer occurring during the activation step, and relatively slow comproportionation and disproportionation. In SARA ATRP slow activation of alkyl halides by Cu0 and comproportionation of CuII with Cu0 compensates for the small number of radicals lost to termination reactions. Alternatively, a mechanism named single electron transfer living radical polymerization (SET-LRP) assumes that the CuI species do not activate alkyl halides, but undergo instantaneous disprop.
Disordered Assembly of MFI Zeolite Nanosheets with a Large Volume of Intersheet Mesopores

MFI zeolite nanosheets with a single-unit-cell crystal thickness were syn-thesized under hydrothermal synthesis conditions using diquaternary ammonium surfactants as the zeolite structure-generating agent. The zeolite structure generation process was analyzed from X-ray powder diffraction, N2 adsorption isotherms, scanning electron micrographs, and transmission electron micrographs of the porous materials generated at various reaction times. This analysis indicated that the nanosheets were initially generated as a disordered assembly that transformed into an ordered multilamellar mesostructure through a dissolution−recrystallization process upon prolonged hydrothermal aging. Synthesis factors affecting the rates of the initial generation of the nanosheets and their restructuring process were investigated while varying the temperature, structure of the surfactant tail, synthesis compositions, and basicity. On the basis of the result, it was possible to synthesize MFI zeolite nanosheets as a fully disordere.
Chemical Composition of Essential Oil from Leaves, Stems and Flowers of Kelussia odoratissima Mozaff. Grown in Iran

Abstract The essential oils of the aerial parts (flower, stem and leaf) of Kelussia odoratissima Mozaff. were analyzed by GC and GC-MS. Although all samples showed similar overall chemical compositions, the major components of the stem were identified as being borneol (36.9 %), bornyl acetate (14.0 %) and 1,8-cineol (13.6 %) and in the flower were found to be 1,8-cineol (22.0 %), camphor (20.1 %), α-pinene (19.0 %) and camphene (12.0 %). In the leaf oil of the plant β-terpinene (23.0 %) was the predominant compounds. All oils were richer in monoterpenes.
Layered cryogels laden with Brazilian honey intended for wound care

– UFRRJ, Seropédica, RJ, Brasil *renatanunes.ufrrj@gmail.com Obstract PVA cryogels are well established as candidate biomaterials for wound healing applications but are not themselves biodegradable or antimicrobial. Blending PVA with NaCMC (CMC) or gelatin (G) can increase the gel’s ability to swell and would introduce a degree of biodegradability. The incorporation of appropriate amounts of a natural antimicrobial/healing agents, such as honey (H), would contribute to the gels properties. The present work addresses the development and characterization of layered gels (PVA-H, PVA-CMC-H and PVA-G-H, with empty PVA, PVA-CMC, PVA-G gels presented as controls). The gels were characterized by FTIR, DSC, in vitro analysis of swelling and microbiological ( S. aureus ) effects. Addition of gelatin, NaCMC and honey to PVA diminished the PVA chains’ ability to pack into crystallites. Samples containing honey swelled less and presented higher weight loss/biodegradability than samples without honey.
Histological comparison between irradiated and non-irradiated breasts in breast reconstruction

1 Hospital Daher Lago Sul, Brasília, DF, Brazil. Conflicts of interest: none. Introduction: The treatment of breast cancer includes not only curative therapies but also breast reconstruction. Radiotherapy, an adjuvant strategy, provides favorable outcomes by reducing the rate of recurrence of the disease. This study aimed to compare histological differences between irradiated and non-irradiated breasts in the same patient. Methods: This is a prospective cohort study of patients undergoing breast reconstruction with prosthesis or expander under pectoralis major muscle flap that compared histological skin patterns, subcutaneous cell tissue, pectoralis major muscle, and implant capsule of irradiated and non-irradiated breasts in paired samples of the same patient. All patients included in this study were irradiated in only one breast. The results of the anatomopathological analysis were compared to clinical findings and intraoperative macroscopic aspects. Results: The study included a total of 7 patients with a mean age of 52.15 years. The main histological findings in the skin and subcutaneous cellular tissue of the irradiated breast were as follows: epidermal hyperplasia, flattening of the papillary layer, atrophy of the skin appendages, vascular congestion in fatty tissue, high density of skin collagen fibers, hyalinization, and reduction of elastic fibers in the deep dermis and unidirectional alignment of collagen fibers. The main histological findings for the capsule and pectoralis major muscle in the irradiated breast were as follows: lower density of elastic fibrosis, perivascular fibrosis, synovial metaplasia, skeletal muscle sequestration at the interface with the capsule, capsular hyalinization, and capsular fribrosclerosis. Conclusion: We found common histological changes in irradiated breasts in most patients. These findings are compatible with the clinical and macroscopic changes observed. This study presents itself as a pilot for the development of further studies investigating the physiopathological mechanisms of the described histological changes. ■ ABSTRACT