Miracle-dz/UniFAR-FTUs huggingface dataset:
Coronary angioplasty in diabetic patients. The National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry.

BACKGROUND Patients with diabetes mellitus are at increased risk of cardiovascular disease. To date, the baseline status and subsequent outcomes of diabetic coronary angioplasty (percutaneous transluminal coronary angioplasty, or PTCA) patients with advanced atherosclerotic disease and with procedures performed across North America have not been well characterized. METHODS AND RESULTS Data on baseline clinical and angiographic characteristics and short- and long-term outcomes of 281 diabetic and 1833 nondiabetic PTCA patients in the multicenter National Heart, Lung, and Blood Institute 1985-1986 PTCA Registry were analyzed. Diabetic patients were older, were more likely to be female, and had more comorbid baseline conditions, triplevessel disease, and atherosclerotic lesions. Angiographic success and completeness of revascularization did not differ significantly, yet diabetic patients experienced more in-hospital death (women) and nonfatal myocardial infarction. Nine-year mortality was twice as high in diabetic patients (35.9% versus 17.9%). Similarly, 9-year rates of nonfatal myocardial infarction (29.0% versus 18.5%), bypass surgery (36.7% versus 27.4%), and repeat PTCA (43.7% versus 36.5%) were higher in diabetics than in nondiabetics. In multivariate analysis, diabetes remained a significant predictor of decreased 9-year survival and other untoward events. CONCLUSIONS Compared with nondiabetic PTCA patients, diabetic patients have more extensive and diffuse atherosclerotic disease. Despite similar probability of angiographic success, diabetic patients are more likely to suffer in-hospital death(women) and nonfatal myocardial infarction. Long-term survival and freedom from myocardial infarction and coronary revascularization is also reduced in diabetic PTCA patients. Whether PTCA or coronary bypass surgery is more suitable for these patients is currently under investigation.
Quantum Dimensions in Logarithmic CFT

Logarithmic vertex operator algebras possess at least one module that is not completely reducible. In these cases not much is known about the relation between torus one-point functions and the representation category. I will review recent progress and discuss a conjecture that makes such a connection. The rational modular story. In 1988 Verlinde observed that modular properties of characters of rational conformal field theories (CFTs) and the fusion ring of modules are closely connected [17]. For this let {M0,M1, . ,Mn} be the set of inequivalent simple modules of a given CFT with M0 the vacuum. Then the character of a module is
Marker-assisted selection for commercial crossbred performance 1

Several studies have shown that selection of purebreds for increased performance of their crossbred descendants under field conditions is hampered by low genetic correlations between purebred and commercial crossbred (CC) performance. Although this can be addressed by including phenotypic data from CC relatives for selection of purebreds through combined crossbred and purebred selection (CCPS), this also increases rates of inbreeding and requires comprehensive systems for collection of phenotypic data and pedigrees at the CC level. This study shows that both these limitations can be overcome with marker-assisted selection (MAS) by using estimates of the effects of markers on CC performance. To evaluate the potential benefits of CC-MAS, a model to incorporate marker information in selection strategies was developed based on selection index theory, which allows prediction of responses and rates of inbreeding by using standard deterministic selection theory. Assuming a genetic correlation between purebred and CC performance of 0.7 for a breeding program representing a terminal sire line in pigs, CC
DFKI-DKT at SemEval-2017 Task 8: Rumour Detection and Classification using Cascading Heuristics

We describe our submissions for SemEval-2017 Task 8, Determining Rumour Veracity and Support for Rumours. The Digital Curation Technologies (DKT) team at the German Research Center for Artificial Intelligence (DFKI) participated in two subtasks: Subtask A (determining the stance of a message) and Subtask B (determining veracity of a message, closed variant). In both cases, our implementation consisted of a Multivariate Logistic Regression (Maximum Entropy) classifier coupled with hand-written patterns and rules (heuristics) applied in a post-process cascading fashion. We provide a detailed analysis of the system performance and report on variants of our systems that were not part of the official submission.
Negative symptoms in depressed and schizophrenic patients: how do they differ?

BACKGROUND The present study evaluated differences in negative symptoms between schizophrenic and depressive patients and investigated whether a consideration of the nature of negative symptoms (enduring vs. nonenduring) can help to improve their specificity for schizophrenia. METHOD Patients enrolled in the study were consecutively hospitalized with an acute exacerbation of schizophrenia (N = 33) or major depressive disorder (N = 43) (DSM-IV). Negative and depressive symptoms were assessed with the Scale for the Assessment of Negative Symptoms (SANS) and the Montgomery-Asberg Depression Rating Scale, respectively. Duration of negative symptoms was assessed through a semistructured interview with the patients and their closest relatives. On the basis of the assessed duration of symptoms, negative symptoms were categorized as enduring or nonenduring. RESULTS Analyses revealed high SANS ratings for both diagnostic groups. Negative symptoms in depressive patients (p =.01), but not in schizophrenic patients, were significantly associated with the presence or the emergence of depressive symptoms. The prevalence of enduring negative symptoms was significantly higher in schizophrenic patients than in depressive patients (p <.01). A consideration of enduring negative symptoms significantly increased the discriminative power of negative symptoms for schizophrenia (p =.02). CONCLUSION The present findings suggest that negative symptoms in most depressive patients are just an epiphenomenon of depressive symptoms and can be distinguished from schizophrenic negative symptoms.
Effect of Porosity on the Capacity Fade of a Lithium-Ion Battery Theory

A mathematical model is presented to predict the performance of a lithium-ion battery. It includes the changes in the porosity of the material due to the reversible intercalation processes and the irreversible parasitic reaction. The model was also extended to predict the capacity fade in a lithium-ion battery based on the unwanted parasitic reaction that consumes Li' along with the changes in the porosities of the electrodes with cycling due to the continuous parasitic side reaction. The model can be used to predict the drop in the voltage profile, change in the state of charge, and the effects of charge and discharge rates during cycling.
China collection 2.1: Aerosol Optical Depth dataset for mainland China at 1km resolution

A wide range of data products have been published since the operation of the Moderate Resolution Imaging Spectroradiometer (MODIS) sensor on NASA's TERRAModerate Resolution Imaging Spectroradiometer (MODIS) sensor on NASA's TERRA and AQUA satellites. Based on DarkTarget and DeepBlue method, NASA has published Aerosol Optical Depth (AOD) products Collection 6.0 with spatial resolution of 3km. Although validated globally, regional and systematic errors are still found in the MODIS-retrieved AOD products. This is especially remarkable for bright heterogeneous land surface, such as mainland China. In order to solve the aerosol retrieval problem over heterogeneous bright land surface, the Synergetic Retrieval of Aerosol Properties algorithm (SRAP) has been developed based on the synergetic use of the MODIS data of TERRA and AQUA satellites. Using the SRAP algorithm, we produced AOD dataset-China Collection 2.1 at 1km spatial resolution, dated from August 2002 to 2012. We compared the China Collection 2.1 AOD datasets for 2010 with AERONET data. From those 2460 collocations, representing mutually cloud-free conditions, we find that 62% of China Collection 2.1 AOD values comparing with AERONET-observed values within an expected error envelop of 20% and 55% within an expected error envelop of 15%. Compared with MODIS Level 2 aerosol products, China Collection 2.1 AOD datasets have a more complete coverage with fewer data gaps over the study region.
Design Rule and Orientation Layout for MEMS Curved Beams on Silicon

An analysis method used to choose a suitable structural orientation layout for a microcompliant mechanism, which includes multi-curved-beams, is introduced, particularly, for fabricating microelectromechanical-systems (MEMS) thin-curved-beam microstructures on (100) and (111) single-crystal silicon (SCS) wafers. The achievement of a large deflection of a fabricated SCS device verifies the usability of this design rule. The orientation layouts of the device for a large deflection are restricted to a specific region. Based on the analysis method, it is better to follow a 21° safe region between the ¿100 ¿ and ¿110 ¿ orientations in order to decrease the possibility of crystal slip failure. Using this design consideration, one can design more robust MEMS compliant mechanisms from SCS, exploiting its ideal elasticity.
Variation in the resumption of cycling and conception by fecal androgen and estradiol levels in female Northern Muriquis (Brachyteles hypoxanthus)

We measured fecal androgen (T+DHT) and estradiol (E2) levels in female northern muriquis (Brachyteles hypoxanthus) at the Estação Biológica de Caratinga/RPPN Feliciano Miguel Abdala, Minas Gerais, Brazil, to evaluate the hormonal bases underlying individual variation in the resumption of cycling and conception. We found that androgen levels were significantly lower in females than in males, and that there were no consistent patterns in female androgen levels across precycling or cycling conditions. Females that resumed cycling earlier in the study (weeks 4–8) had higher precycling E2 levels and correspondingly lower precycling androgen/E2 ratios than females that resumed cycling later (weeks 12–16). There were no differences in female precycling androgen levels, but cycling females that conceived during or immediately after the study period had lower androgen levels and threefold higher E2 peaks than the one cycling female that failed to conceive. These results suggest that minimum E2 thresholds are necessary for both the resumption of ovarian cycling and conception. Individual variation in these components of fertility may be regulated by differences in E2 levels, which affect androgen/E2 ratios, rather than by androgen levels per se. Further research into the relative concentrations of T vs. DHT will be necessary to fully evaluate whether androgens affect cycling and conception in this species. Am. J. Primatol. 67:69–81, 2005. © 2005 Wiley‐Liss, Inc.
Sustainable cost reduction by lean management in metallurgical processes

This paper focuses on the need for sustainable cost reduction in the metallurgical industry by applying Lean Management (LM) tools and concepts in metallurgical production processes leading to increased competitiveness of corporations in a global market. The paper highlights that Lean Management is a novel way of thinking, adapting to change, reducing waste and continuous improvement, leading to sustainable development of companies in the metallurgical industry. The authors outline the main Lean Management instruments based on recent scientific research and include a comparative analysis of other tools, such as Sort, Straighten, Shine, Standardize, Sustain (5S), Visual Management (VM), Kaizen, Total Productive Maintenance (TPM), Single-Minute Exchange of Dies (SMED), leading to a critical appraisal of their application in the metallurgical industry.
Some DNA-repair-deficient human syndromes and their implications for human health

Several human syndromes are described with which have been associated a deficiency in the ability to repair damage to cellular DNA. This deficiency is generally manifested as a sensitivity to DNA-damaging agents such as u. v. light, ionizing radiation, or psoralen photosensitization (PUVA). In xeroderma pigmentosum (XP) a high frequency of light-induced skin cancers is correlated with hypermutability of fibroblasts following u. v. irradiation in vitro, providing telling support for the somatic mutation theory of cancer. Closer inspection, however, reveals that a pseudopromoting action of light or PUVA may be equally important in skin carcinogenesis in both XP and normal individuals. It is suggested that impairment of cell-mediated immune response in the skin (possibly by DNA damage) may be responsible for this pseudopromoting action. That more than an enhanced frequency of somatic mutation is necessary for early skin neoplasms is illustrated by Cockayne syndrome (and possibly patient 11961), where XP-like changes in the skin are not observed despite an enhanced u. v. mutability of cultured fibroblasts. Xeroderma pigmentosum, ataxia-telangiectasia and Cockayne syndrome all show progressive neurological disease, suggesting that common factors are involved in DNA repair and the normal development and function of the nervous system. Fibroblasts from certain Huntington’s disease patients also show some sensitivity to ionizing radiation but this cannot at present be attributed to a DNA-repair deficiency. Patients with ataxia-telangiectasia also show a severely depressed immune response, and a search for other individuals with impaired immunity revealed patient 46BR, whose cells are sensitive to a wide range of DNA-damaging agents. It is suggested that common factors may be involved in DNA repair and the proper development and functioning of the immune system. One possibility is (by analogy with the recA mutation in bacteria) that common steps exist between some types of DNA repair and the somatic recombination events that are involved in the generation of immunoglobulin genes. Human DNA-repair-deficient mutants may not yet have proved their value in yielding an understanding of the molecular mechanisms of DNA repair, but they have shown that several unexpected aspects of human health may be linked to functional DNA-repair processes.
Development of bovine blastocyst with a note on implantation

The developnient of bovine ova up to the stage of blastocyst formation (Hamilton and Laing, '46) and the prenatal development ( M7inters, Green and Comstock, '42) have been reported. A detailed study of bovine blastocysts, however, is lacking. This paper describes a series of bovine blastocysts with a note on the implantation of bovine embryos.
Calreticulin promotes angiogenesis via activating nitric oxide signalling pathway in rheumatoid arthritis

Calreticulin (CRT) is a multi‐functional endoplasmic reticulum protein implicated in the pathogenesis of rheumatoid arthritis (RA). The present study was undertaken to determine whether CRT was involved in angiogenesis via the activating nitric oxide (NO) signalling pathway. We explored the profile of CRT expression in RA (including serum, synovial fluid and synovial tissue). In order to investigate the role of CRT on angiogenesis, human umbilical vein endothelial cells (HUVECs) were isolated and cultured in this study for in‐vitro experiments. Our results showed a significantly higher concentration of CRT in serum (5·4 ± 2·2 ng/ml) of RA patients compared to that of osteoarthritis (OA, 3·6 ± 0·9 ng/ml, P < 0·05) and healthy controls (HC, 3·7 ± 0·6 ng/ml, P < 0·05); and significantly higher CRT in synovial fluid (5·8 ± 1·2 ng/ml) of RA versus OA (3·7 ± 0·3 ng/ml, P < 0·05). High levels of CRT are expressed in synovial membrane localized predominantly to inflammatory cells and synovial perivascular areas in both the lining and sublining layers of RA synovial tissue (RAST). Increased nitric oxide (NO) production and phosphorylation level of endothelial nitric oxide synthase (eNOS) were measured in HUVECs following CRT stimulation, while the total eNOS expression was not significantly changed. Furthermore, CRT promoted the proliferation, migration and tube formation of HUVECs, which were significantly inhibited by a specific eNOS inhibitor. These findings suggested that CRT may be involved in angiogenesis events in RA through NO signalling pathways, which may provide a potential therapeutic target in the treatment of RA.
Arginine 246 of the Pretransmembrane Domain 1 Region Alters 2,2,2-Trichloroethanol Action in the 5-Hydroxytryptamine3A Receptor

Ligand-gated ion channels participate in synaptic transmission, and they are involved in neurotransmitter release. The functions of the channels are regulated by a variety of modulators. The interaction of 2,2,2-trichloroethanol, the active hypnotic metabolite of chloral hydrate, with the 5-hydroxytryptamine (5-HT) (serotonin) type 3 receptor results in a positive allosteric modulation. We have demonstrated previously that arginine 246 (R246) located in the pretransmembrane domain 1 is critical for coupling agonist binding to gating. In this study, we examined the role of R246 in the action of trichloroethanol with a combination of mutagenesis and whole-cell patch-clamp techniques. The R246A mutation converted the partial agonist dopamine into a full agonist at the 5-HT3A receptor, and it facilitated activation of the mutant receptor by dopamine, suggesting an enhanced gating process due to the mutation. The positive modulation of the 5-HT3A receptor by trichloroethanol was dramatically reduced by the R246A mutation. Trichloroethanol had little agonist activity in the wild-type receptor (<1% of maximal 5-HT response). However, the R246A mutation significantly increased the direct activation of the receptor by trichloroethanol in the absence of agonist (∼10% of maximal 5-HT response). The current activated by trichloroethanol could be blocked by the competitive 5-HT3 receptor antagonist tropanyl 3,5-dichlorobenzoate (MDL 72222), and it had a similar reversal potential to those of current activated by 5-HT. In addition, predesensitization of the mutant receptor by trichloroethanol prevented 5-HT from activating the receptor. These data suggest that R246 is a crucial site for mediating the actions of both agonists and modulators.
Ultracompact SOI CMOS frequency doubler for low power applications at 26.5-28.5 GHz

In this paper, a complementary metal oxide semiconductor (CMOS) frequency doubler for wireless applications at Ka-band is presented. The microwave monolithic integrated circuit (MMIC) is fabricated using digital 90 nm silicon on insulator (SOI) technology. All impedance matching, filter and bias elements are implemented on the chip, which has a very compact size of 0.37 mm/spl times/0.27 mm. At an output frequency of 27 GHz, source/load impedances of 50 /spl Omega/, a supply voltage of 1.25 V, a supply current of 8 mA and an input power of -4.5 dBm, a conversion gain of 1.5 dB was measured. To the knowledge of the authors, the circuit has by far the highest operation frequency for a CMOS frequency multiplier reported to date and requires lower supply power than circuits using leading edge III/V and silicon germanium (SiGe) technologies.
Effects of stimulus rate on the feline brain-stem auditory evoked response during development. II. Peak amplitudes.

The effects of click rate on brain-stem auditory evoked response (BAER) peak amplitudes were investigated in adult cats and kittens in four age groups: 10, 15, 20, and 30 post-natal days. Conventional BAERs were obtained at rates of 5, 10, 30, 60, and 90 Hz. Maximum length sequences (MLSs) were used to obtain responses at rates of 83, 125, 250, 500, and 1000 Hz. For both techniques, clicks were presented at 90 dB pSPL, and at 20 dB above threshold (20 dB SL). BAERs were observed for all age groups, at all click rates. However, not all peaks could be identified in all animals, with peak absence more common for the youngest kittens at the higher rates. BAER waves i through iv decreased in amplitude with increasing click rate for all age groups. In general, the smallest peak amplitudes were observed for the youngest animals (10- to 15-day-old) studied, while the largest amplitudes were found for the adult, 20- or 30-day-old animals, regardless of rate. When amplitudes were normalized to eliminate the influences of differences in absolute values due to developmental stage (i.e., made proportional to the amplitude observed at 5 Hz), the younger age groups exhibited enhanced sensitivity to the effects of stimulus rate. However, exceptions to this trend were observed. In general, amplitudes of BAER peaks obtained with the MLS procedure were smaller than those obtained using conventional averaging with a similar average click rate, regardless of age. Finally, the most efficient method for obtaining a response at a criterion signal-to-noise ratio was typically by the use of conventional averaging at a rate of 60 or 90 Hz, for all peaks and age groups, Overall, these data suggest that higher stimulus rates produce greater neural adaptation resulting in reduced BAER peak amplitudes. The mechanism responsible for the acquisition of adult-like adaptation properties appears to develop during the early post-natal period in the cat.
A pilot study evaluating a home exercise DVD for patients who reside in a rural and remote location.

Objectives: Home exercise programs are an important component of a hand therapy rehabilitation program. Compliance with the recommended home exercise regime is generally considered essential for good treatment outcomes. The aim of this pilot was to determine the clarity of an innovative hand therapy DVD. This DVD will be utilised in a randomised controlled trial (RCT) examining the usefulness of DVD technology for enhancing treatment compliance for rural and remote hand therapy patients. Methods: A series of seven DVDs of previously utilised home exercise protocols were taped and edited by the researchers. The pilot used a convenience sample of nine consecutive consenting patients who attended the Hand Therapy Service at a regional hospital in North Queensland. Subjects viewed a DVD that related to their clinical diagnosis and then completed a questionnaire on the suitability of the research instrument. Results: There were unanimously positive responses to the DVD from all subjects, with 100% indicating yes to the prompt questions. No negative comments were received. Discussion: The DVDs produced were found to be clear and useful for a group of hand therapy patients characteristically similar to those who will be recruited into the RCT. Resulting compliance with these home exercises will be presented in a subsequent paper resulting from the RCT. Given the poor health outcomes generally associated with patients from rural and remote areas, this endeavour contributes to the ongoing effort to improve service delivery to better address the health needs of rural and remote patients.
Importance of Ribosomal Frameshifting for Human Immunodeficiency Virus Type 1 Particle Assembly and Replication

ABSTRACT The recent development and use of protease inhibitors have demonstrated the essential role that combination therapy will play in the treatment of individuals infected with the human immunodeficiency virus type 1 (HIV-1). Past clinical experience suggests that due to the appearance of resistant HIV-1 variants, additional therapeutics will be required in the future. To identify new options for combination therapy, it is of paramount importance to pursue novel targets for drug development. Ribosomal frameshifting is one potential target that has not been fully explored. Data presented here demonstrate that small molecules can stimulate frameshifting, leading to an imbalance in the ratio of Gag to Gag-Pol and inhibiting HIV-1 replication at what appears to be the point of viral particle assembly. Thus, we propose that frameshifting represents a new target for the identification of novel anti-HIV-1 therapeutics.