Miracle-dz/UniFAR-FTUs huggingface dataset:
Recherche d'informations sur le Web basée sur des données d'opinion

Résumé. Avec la diversification du contenu disponible sur le Web, aussi bien en quantité qu’en qualité, retrouver l’information pertinente est problématique. Les moteurs de recherche d’informations sur le Web ont comme objectif de permettre de retrouver efficacement l’information pertinente. Ces moteurs implémentent différentes stratégies pour déterminer la pertinence des pages Web. Ces dernières sont classées en se basant principalement sur des critères d’évaluation automatisés, ce qui crée un vide entre la pertinence effective d’un contenu et la pertinence calculée. Afin de réduire cet écart, nous présentons un cadre d’application de moteur de recherche où la pertinence d’une page Web est calculée à partir des évaluations des internautes du contenu de la page (texte, image, audio, vidéo,.). Pour illustrer l’exploitation du cadre proposé, nous avons développé le moteur de recherche expérimental SocialSeeker(Adda, 2008). Finalement, une étude empirique préliminaire du potentiel du prototype est présentée et discutée
Role-Engineering Optimization with Cardinality Constraints and User-Oriented Mutually Exclusive Constraints

Role-based access control (RBAC) is one of the most popular access-control mechanisms because of its convenience for management and various security policies, such as cardinality constraints, mutually exclusive constraints, and user-capability constraints. Role-engineering technology is an effective method to construct RBAC systems. However, mining scales are very large, and there are redundancies in the mining results. Furthermore, conventional role-engineering methods not only do not consider more than one cardinality constraint, but also cannot ensure authorization security. To address these issues, this paper proposes a novel method called role-engineering optimization with cardinality constraints and user-oriented mutually exclusive constraints (REO_CCUMEC). First, we convert the basic role mining into a clustering problem, based on the similarities between users and use-partitioning and compression technologies, in order to eliminate redundancies, while maintaining its usability for mining roles. Second, we present three role-optimization problems and the corresponding algorithms for satisfying single or double cardinality constraints. Third, in order to evaluate the performance of authorizations in a role-engineering system, the maximal role assignments are implemented, while satisfying multiple security constraints. The theoretical analyses and experiments demonstrate the accuracy, effectiveness, and efficiency of the proposed method.
Real-time 3D Environment Mapping: Occlusion and Collision in Augmented Reality

Achieving realistic augmented reality gives us several complex challenges to solve. Past work has shown that in most cases the technology available was not up to the task. However, the advances made in recent years have drastically changed the possibilities, and in this thesis we investigate them. To aid in this, we categorize augmented reality systems based on the type of information they use. The categorization shows us that we have not yet achieved a truly realistic merging of the virtual world with our real world. This thesis examines the basic operations we need for that purpose. By solving the collision and occlusion problems, we lay the groundwork for further work in achieving realistic augmented reality. We create a testbed and define metrics for quantifying the performance of our system, with respect to collision and occlusion. This testbed can be used to quantify the performance of any augmented reality system, and we apply it to our own implementation. The results show that we have defined a working testing methodology, and using the testbed we show that the Kinect V2 depth-sensor is suitable for 3D environment mapping. The collision and occlusion results become worse when too much smoothing is applied, or when upsampling introduces too much noise. Limitations of this thesis are that we implemented the system on the CPU only, when a GPU approach would produce better running time performance. Based on this thesis, future work can be performed on merging virtual lighting with the real world. Real-time 3D Environment Mapping: Occlusion and Collision in Augmented Reality iii
Ossifying Fibromyxoid Tumor: A Review With Emphasis on Recent Molecular Advances and Differential Diagnosis.

CONTEXT. — Ossifying fibromyxoid tumor (OFMT) is a rare, slow-growing mesenchymal neoplasm of uncertain histogenesis with intermediate malignant potential. OBJECTIVE. — To highlight the most important diagnostic features, including morphologic, immunohistochemical, and molecular findings; to provide comparisons to other entities in the differential diagnosis; and to provide a summary of the clinical features and outcomes in cases reported to date. DATA SOURCES. — The data sources include recently published literature encompassing OFMT and tumors in the histologic differential diagnosis, and cases from institutional files. CONCLUSIONS. — Ossifying fibromyxoid tumor is important to recognize because of its low-grade morphology but potential for recurrence and metastasis. Recent molecular analysis has expanded the morphologic spectrum of OFMT, with additional cases discovered that are enriched for aggressive behavior. The diagnosis can often be rendered through a combination of morphology and coexpression of S100 protein and desmin, although only a minority of cases described contain all of these primary features. In cases that do not have all of these features, a high index of suspicion guided by morphology and exclusion of other tumors in the histologic differential diagnosis can lead to the correct diagnosis. Growing access to molecular genetic testing will become increasingly important for correct diagnosis of tumors at the ends of the morphologic spectrum.
Effects of Outdoor Access and Indoor Stocking Density on Behaviour and Stress in Broilers in the Subhumid Tropics

Simple Summary The stressors affecting chickens in farming systems differ from those confronting their wild ancestors; thus, the ability to cope with an outdoor environment may have been modified. There is a growing body of literature that recognises the importance of allowing chickens to express their natural behaviour by providing outdoor access. However, studies investigating the effects of offering outdoor access to housed meat chickens in the tropics are scarce. Therefore, the effects of allowing chickens outdoor access, with two indoor space allowances, on their growth, behaviour and responses to stress were assessed. Some blood parameters indicated that outdoor access reduced stress, but the behavioural effects of providing outdoor access depended on indoor stocking density. Birds at the high stocking density with outdoor access were found standing for longer periods of time and those at the high stocking density and no outdoor access were observed walking less and lying more than the other three groups. It is concluded that there were welfare benefits of outdoor access, principally in terms of increased activity, but slower growth resulted in lighter birds at the end of the study. Abstract Studies investigating the welfare of commercial-line broiler chickens raised in houses with outdoor access in the tropics are scarce, and none have investigated whether responses vary according to indoor conditions. Hence, we assessed the effects of providing outdoor access at two indoor stocking densities on broiler chickens’ growth, behaviour, stress responses and immunity in a tropical region of Mexico. One hundred and sixty chickens were assigned to one of four treatments in a factorial design: with or without outdoor access and low or high stocking density indoors. Ad libitum sampling was used to build a purpose-designed ethogram. Scan sampling was used to record the number of birds engaged in each activity of this ethogram, both indoors and outdoors. Heterophil/lymphocyte (H/L) ratio and serum corticosterone levels were tested in weeks four and six of age. When the birds were 42 days old, they were slaughtered, and the bursa and spleen harvested and weighed. In an interaction between stocking density and outdoor access, birds at the high stocking density with no outdoor pens spent the least time walking and preening and more time lying (p < 0.05). Birds given outdoor access foraged more, but only at indoor low stocking densities (p < 0.05). Outdoor access reduced heterophil/lymphocyte ratio, indicating reduced stressor response. Birds with low stocking density indoors and outdoor access appeared more responsive to stressors, with elevated corticosterone and reduced spleen and bursa weights (p < 0.05). There were welfare benefits of outdoor access, principally in terms of increased activity, which were reflected in slower growth in the birds with outdoor access.
The Clinicopathological Spectrum of Acromegaly

Background: Acromegaly results from a persistent excess in growth hormone with clinical features that may be subtle or severe. The most common cause of acromegaly is a pituitary tumor that causes excessive production of growth hormone (GH), and rare cases are due to an excess of the GH-releasing hormone (GHRH) or the ectopic production of GH. Objective: Discuss the different diseases that present with manifestations of GH excess and clinical acromegaly, emphasizing the distinct clinical and radiological characteristics of the different pathological entities. Methods: We performed a narrative review of the published clinicopathological information about acromegaly. An English-language search for relevant studies was conducted on PubMed from inception to 1 August 2019. The reference lists of relevant studies were also reviewed. Results: Pituitary tumors that cause GH excess have several variants, including pure somatotroph tumors that can be densely or sparsely granulated, or plurihormonal tumors that include mammosomatotroph, mixed somatotroph-lactotroph tumors and mature plurihomonal Pit1-lineage tumors, acidophil stem cell tumors and poorly-differentiated Pit1-lineage tumors. Each tumor type has a distinct pathophysiology, resulting in variations in clinical manifestations, imaging and responses to therapies. Conclusion: Detailed clinicopathological information will be useful in the era of precision medicine, in which physicians tailor the correct treatment modality to each patient.
Assessing the Russian Internet Research Agency’s impact on the political attitudes and behaviors of American Twitter users in late 2017

Significance While numerous studies analyze the strategy of online influence campaigns, their impact on the public remains an open question. We investigate this question combining longitudinal data on 1,239 Republicans and Democrats from late 2017 with data on Twitter accounts operated by the Russian Internet Research Agency. We find no evidence that interacting with these accounts substantially impacted 6 political attitudes and behaviors. Descriptively, interactions with trolls were most common among individuals who use Twitter frequently, have strong social-media “echo chambers,” and high interest in politics. These results suggest Americans may not be easily susceptible to online influence campaigns, but leave unanswered important questions about the impact of Russia’s campaign on misinformation, political discourse, and 2016 presidential election campaign dynamics. There is widespread concern that Russia and other countries have launched social-media campaigns designed to increase political divisions in the United States. Though a growing number of studies analyze the strategy of such campaigns, it is not yet known how these efforts shaped the political attitudes and behaviors of Americans. We study this question using longitudinal data that describe the attitudes and online behaviors of 1,239 Republican and Democratic Twitter users from late 2017 merged with nonpublic data about the Russian Internet Research Agency (IRA) from Twitter. Using Bayesian regression tree models, we find no evidence that interaction with IRA accounts substantially impacted 6 distinctive measures of political attitudes and behaviors over a 1-mo period. We also find that interaction with IRA accounts were most common among respondents with strong ideological homophily within their Twitter network, high interest in politics, and high frequency of Twitter usage. Together, these findings suggest that Russian trolls might have failed to sow discord because they mostly interacted with those who were already highly polarized. We conclude by discussing several important limitations of our study—especially our inability to determine whether IRA accounts influenced the 2016 presidential election—as well as its implications for future research on social media influence campaigns, political polarization, and computational social science.
Sumoylation of the DNA polymerase ε by the Smc5/6 complex contributes to DNA replication

DNA polymerase epsilon (Pol ε) is critical for genome duplication, but little is known about how post-translational modification regulates its function. Here we report that the Pol ε catalytic subunit Pol2 in yeast is sumoylated at a single lysine within a catalytic domain insertion uniquely possessed by Pol2 family members. We found that Pol2 sumoylation occurs specifically in S phase and is increased under conditions of replication fork blockade. Analyses of the genetic requirements of this modification indicate that Pol2 sumoylation is associated with replication fork progression and dependent on the Smc5/6 SUMO ligase known to promote DNA synthesis. Consistently, the pol2 sumoylation mutant phenotype suggests impaired replication progression and increased levels of gross chromosomal rearrangements. Our findings thus indicate a direct role for SUMO in Pol2-mediated DNA synthesis and a molecular basis for Smc5/6-mediated regulation of genome stability.
Transcriptome Sequencing Reveals the Traits of Spermatogenesis and Testicular Development in Large Yellow Croaker (Larimichthys crocea)

Larimichthys crocea is an economically important marine fish in China. To date, the molecular mechanisms underlying testicular development and spermatogenesis in L. crocea have not been thoroughly elucidated. In this study, we conducted a comparative transcriptome analysis between testes (TES) and pooled multiple tissues (PMT) (liver, spleen, heart, and kidney) from six male individuals. More than 54 million clean reads were yielded from TES and PMT libraries. After mapping to the draft genome of L. crocea, we acquired 25,787 genes from the transcriptome dataset. Expression analyses identified a total of 3853 differentially expressed genes (DEGs), including 2194 testes-biased genes (highly expressed in the TES) and 1659 somatic-biased genes (highly expressed in the PMT). The dataset was further annotated by blasting with multi-databases. Functional genes and enrichment pathways involved in spermatogenesis and testicular development were analyzed, such as the neuroactive ligand–receptor interaction pathway, gonadotropin-releasing hormone (GnRH) and mitogen-activated protein kinase (MAPK) signaling pathways, cell cycle pathway, and dynein, kinesin, myosin, actin, heat shock protein (hsp), synaptonemal complex protein 2 (sycp2), doublesex- and mab-3-related transcription factor 1 (dmrt1), spermatogenesis-associated genes (spata), DEAD-Box Helicases (ddx), tudor domain-containing protein (tdrd), and piwi genes. The candidate genes identified by this study lay the foundation for further studies into the molecular mechanisms underlying testicular development and spermatogenesis in L. crocea.
Group and Single Housing of Male Mice: Collected Experiences from Research Facilities in Sweden

Simple Summary The mouse is the most commonly used mammal in scientific research, and housed in research facilities around the world. Mice are a social species, but when housing male mice together in a confined environment in the laboratory, aggression is often observed and can be problematic. Fighting or trying to avoid fighting can be stressful. Furthermore, fighting can lead to injuries which can sometimes be fatal. Mouse aggression is therefore a significant welfare problem and has implications on the 3Rs (Replacing, Reducing, and Refining animal use in scientific procedures and education). In this study, we used a survey and workshops to collect the experiences of animal technicians, veterinarians, and researchers at Swedish research animal facilities relating to mouse aggression and what methods of preventing aggression they practice. Both group housing and single-housing as a consequence of aggression was perceived as problematic and stressful for the animals. In line with current recommendations from the literature, participants perceived that aggression occurred less if mice were grouped with litter mates at an early age, that nesting material was transferred at cage cleaning, and disturbance was kept to a minimum. Experience from practice will play a valuable part in developing guidelines for group-housed male mice. Abstract Animals used for scientific purposes are protected by EU legislation. Social animals should be kept in stable groups that enable species-typical social behavior and provide individuals with social comfort. However, when group-housing male mice, aggression within the homecage is a common husbandry and welfare problem. Excessive fighting and injuries due to aggression can cause pain and stress, resulting in individuals being euthanized or housed individually. In addition, stress can alter physiological parameters, risking scientific validity and generating larger sample sizes. Mouse aggression, and the consequences thereof, thus opposes the 3R goals of Refining the methods to minimize potential pain and suffering and Reducing the number of animals used. Animal technicians, veterinarians, and scientists using animals have valuable information on how these problems are experienced and handled in practice. We assembled these experiences from laboratory animal facilities in Sweden, mapping problems observed and identifying strategies used to prevent mouse aggression. In line with current literature, less aggression was perceived if mice were grouped before sexual maturity, re-grouping avoided and nesting material transferred at cage cleaning. Preventing aggression will minimize pain and suffering and enable housing of stable groups, leading to more reliable scientific outcomes and is thus of high 3Rs relevance.
A Quantized CNN-Based Microfluidic Lensless-Sensing Mobile Blood-Acquisition and Analysis System

This paper proposes a microfluidic lensless-sensing mobile blood-acquisition and analysis system. For a better tradeoff between accuracy and hardware cost, an integer-only quantization algorithm is proposed. Compared with floating-point inference, the proposed quantization algorithm makes a tradeoff that enables miniaturization while maintaining high accuracy. The quantization algorithm allows the convolutional neural network (CNN) inference to be carried out using integer arithmetic and facilitates hardware implementation with area and power savings. A dual configuration register group structure is also proposed to reduce the interval idle time between every neural network layer in order to improve the CNN processing efficiency. We designed a CNN accelerator architecture for the integer-only quantization algorithm and the dual configuration register group and implemented them in field-programmable gate arrays (FPGA). A microfluidic chip and mobile lensless sensing cell image acquisition device were also developed, then combined with the CNN accelerator to build the mobile lensless microfluidic blood image-acquisition and analysis prototype system. We applied the cell segmentation and cell classification CNN in the system and the classification accuracy reached 98.44%. Compared with the floating-point method, the accuracy dropped by only 0.56%, but the area decreased by 45%. When the system is implemented with the maximum frequency of 100 MHz in the FPGA, a classification speed of 17.9 frames per second (fps) can be obtained. The results show that the quantized CNN microfluidic lensless-sensing blood-acquisition and analysis system fully meets the needs of current portable medical devices, and is conducive to promoting the transformation of artificial intelligence (AI)-based blood cell acquisition and analysis work from large servers to portable cell analysis devices, facilitating rapid early analysis of diseases.
Effects of the solubility of yeast cell wall preparations on their potential prebiotic properties in dogs

Derivatives of yeast cell wall (YCW) have been studied for their potential prebiotic effects. Recently, new purified and soluble preparations have been developed in an attempt to increase their biological actions. Two YCW preparations, one conventional and another with higher solubility of the mannan oligosaccharide fraction, were evaluated on dogs. One food formulation was used, divided into the following treatments: CON–control, without yeast cell wall addition; YCW–addition of 0.3% of a conventional yeas cell wall extract; YCWs–addition of 0.3% of a yeast cell wall extract with high mannan oligosaccharide solubility. Twenty-four beagle dogs were used, eight per food, distributed on a block design. Blocks lasted 32 days, and TNF-a, IL-6, IL-10, ex vivo production of hydrogen peroxide and nitric oxide by peripheral neutrophils and monocytes, phagocytic index, and fecal IgA were evaluated at the beginning and end of each period. Additionally, nutrient digestibility, feces production and quality, and fermentation products were quantified. The results were evaluated by analysis of variance and compared using the Tukey test (P<0.05), using the basal immunological parameters as a covariate. The inclusion of YCWs reduced fat digestibility (P<0.05), increased the concentration of butyrate and putrescine, and reduced lactate in feces (P<0.05), showing that mannan oligosaccharide solubilization resulted in higher fermentation of this compound and altered the metabolism of the gut microbiota. Lower IL-6 on serum was verified for dogs fed the YCWs diet (P<0.05), suggesting a reduction in the inflammatory activity of dogs. Higher phagocytic index was verified for peripheral monocytes after the intake of the YCW food, suggesting better innate immunity. In conclusion, the solubilization of the mannooligosaccharide fraction alters its interaction with gut microbiota and biological actions in animals, although both yeast cell wall preparations exhibited prebiotic effects on dogs.
Thirty Years of Cancer Nanomedicine: Success, Frustration, and Hope

Starting with the enhanced permeability and retention (EPR) effect discovery, nanomedicine has gained a crucial role in cancer treatment. The advances in the field have led to the approval of nanodrugs with improved safety profile and still inspire the ongoing investigations. However, several restrictions, such as high manufacturing costs, technical challenges, and effectiveness below expectations, raised skeptical opinions within the scientific community about the clinical relevance of nanomedicine. In this review, we aim to give an overall vision of the current hurdles encountered by nanotherapeutics along with their design, development, and translation, and we offer a prospective view on possible strategies to overcome such limitations.