Miracle-dz/UniFAR-FTUs huggingface dataset:
Diagnosis of Unruptured Ectopic Pregnancy is Still Uncommon in Ghana.

SUMMARY OBJECTIVES To find out why the detection of ectopic pregnancy before its rupture continues to be low at the Korle Bu Teaching Hospital and to suggest ways of improving upon the detection rates. DESIGN Longitudinal retrospective descriptive survey. SETTING Gynaecology unit of Department of Obstetrics and Gynaecology, Korle Bu Teaching Hospital. SUBJECTS AND METHODS Interview, between the 3(rd) and 5(th) post-operative days, of 1492 patients who had operative diagnosis of tubal pregnancy was conducted for socio-demographic data, circumstances of admission with ectopic pregnancy and desire to have more children. The case notes were also reviewed for operative findings. RESULTS The incidence of tubal ectopic pregnancy was 32.90 per 1000 deliveries and unruptured cases formed 5.43%. Lack of awareness of early pregnancy, late reporting by women to health care facilities when aware of pregnancy and failure of health care providers to utilize the diagnostic aids for detecting unruptured ectopic pregnancy (like serum beta human chorionic gonadotrophin and ultrasonography) were the main reasons for the low detection rates. CONCLUSIONS Health education to encourage women to attend clinic early in pregnancy, especially when experiencing unusual symptoms of lower abdominal pain and irregular vaginal bleeding could help in the diagnosis of unruptured ectopic pregnancy. Judicious use of diagnostic aids for detecting unruptured ectopic pregnancy by health care providers should improve upon the detection rates.
Molecular modeling, in silico screening and molecular dynamics of PfPRL-PTP of P. falciparum for identification of potential anti-malarials

Millions of deaths occur every year due to malaria. Growing resistance against existing drugs for treatment of malaria has exaggerated the problem further. There is an intense demand of identifying drug targets in malaria parasite. PfPRL-PTP protein is PRL group of phosphatase, and one of the interesting drug targets being involved in three important pathways of malaria parasite (secretion, phosphorylation, and prenylation). Therefore, in this study, we have modeled three-dimensional structure of PfPRL-PTP followed by validation of 3D structure using RAMPAGE, verify3D, and other structure validation tools. We could identify 12 potential inhibitory compounds using in silico screening of NCI library against PfPRL-PTP with Glide. The molecular dynamics simulation was also performed using GROMACS on PfPRL-PTP model alone and PfPRL-PTP-inhibitor complex. This study of identifying potential drug-like molecules would add up to the process of drug discovery against malaria parasite.
Evolutionary global attitude planning for satellite signature suppression shield

This paper explores the global attitude planning for satellite signature suppression shields with limited attitude control abilities. Space surveillance radar and high energy laser are the main threats to on-orbit satellite. The radar detection probability and laser irradiation power are coupled with the satellite's radar cross section (RCS) and laser cross section (LCS) respectively, which are determined by the shield's attitude. This paper presents an evolutionary global attitude planning algorithm for low observable satellites, to reduce their RCS and LCS in threat directions by limited shield attitude control. A novel evolutionary strategy is developed. The strategy has problem-specific individual structure and evolutionary methods, and is able to find a near-optimal global attitude solution with limited iterative steps. At the same time, a novel planning mathematical model and a relative evolutionary evaluation function are defined to reduce the planning's computational complexity. According to the simulation results, the algorithm is proved to be efficient.
An outbursting protostar of the FU Orionis type in the Cygnus OB7 molecular cloud

Context. To follow the early evolution of stars we need to understand how young stars accrete and eject mass. It is generally assumed that the FU Orionis phenomenon is related to the variations in the disk accretion, but many questions remain still open, in particular because of the rarity of FU Ori type stars. Aims. We explore here the characteristics of the outburst and of the environment of one new object, discovered recently in the active star formation region containing RNO 127, within the Cygnus OB7 dark cloud complex. Methods. We present an extensive optical and near-infrared study of a new candidate of FU Orionis object, including its direct imaging, spectroscopy and scanning Fabry-Perot interferometry. Results. The source, associated with the variable reflection nebula, underwent prodigious outburst. The “Braid” nebula, which appeared in 2000, as is indicated by its name, consists of two intertwined features, illuminated by the outburst. Subsequent NIR observations revealed the bright source, which was not visible on 2MASS images, and its estimated brightening was more than 4 mag. Optical and infrared spectral data show features, which are necessary for the system to be referred to as a FUor object. The bipolar optical flow directed by the axis of nebula also was found. Various estimates give the November/December 1999 as the most probable date for the eruption.
Comparison of Mesenchymal Stem Cells from Different Tissues to Suppress T-Cell Activation

Graft-versus-host disease (GvHD) and graft rejection have remained significant complications of allogeneic stem cell transplantation. Mesenchymal stem cells (MSCs) from the bone marrow have been shown to suppress T-cell activation in vitro and in vivo, and may be used to reduce GvHD in the recipient or to facilitate engraftment across MHC barriers. MSCs can be derived from a variety of tissues. Thus, we asked whether MSCs from different tissues might have differential effects on T-cell responses. We were particularly interested in MSCs derived from adipose tissue because of its abundance and accessibility. We investigated and compared the immunosuppressive potential of murine MSCs derived from muscle tissue, adipose tissue, omentum, and bone. Cells from the different tissues were enriched for MSCs and cultured for 2–3 weeks to deplete hematopoietic cells. Mixed lymphocyte reactions (MLRs) including MSCs were performed using concanavalin A or allogeneic T cells as inducers of T-cell activation. MSCs from all tissues differentiated into multiple lineages. Mitogen-induced T-cell activation, as well as allogeneic T-cell responses, was reduced in MLRs mediated by the addition of MSCs. Reduction of T-cell activation was most pronounced for muscle tissue in the mitogen-induced MLR and fat tissue during the allogeneic MLR. These data demonstrate that MSCs from multiple tissues efficiently reduce T-cell activation. The results suggest that MSCs from adipose tissue can serve as an alternative source for MSCs to bone or bone marrow for the modulation of GvHD after allogeneic stem cell transplantation or to enhance engraftment across MHC barriers.
Semantic component selection

The means of locating information quickly and efficiently is a growing area of research. However the real challenge is not related to locating bits of information, but finding those that are relevant. Relevant information resides within unstructured ‘natural’ text. However, understanding natural text and judging information relevancy is a challenge. The challenge is partially addressed by use of semantic models and reasoning approaches that allow categorisation and (within limited fashion) provide understanding of this information. Nevertheless, many such methods are dependent on expert input and, consequently, are expensive to produce and do not scale. Although automated solutions exist, thus far, these have not been able to approach accuracy levels achievable through use of expert input. This thesis presents SemaCS - a novel nondomain specific automated framework of categorising and searching natural text. SemaCS does not rely on expert input; it is based on actual data being searched and statistical semantic distances between words. These semantic distances are used to perform basic reasoning and semantic query interpretation. The approach was tested through a feasibility study and two case studies. Based on reasoning and analyses of data collected through these studies, it can be concluded that SemaCS provides a domain independent approach of semantic model generation and query interpretation without expert input. Moreover, SemaCS can be further extended to provide a scalable solution applicable to large datasets (i.e. World Wide Web). This thesis contributes to the current body of knowledge by establishing, adapting, and using novel techniques to define a generic selection/categorisation framework. Implementing the framework outlined in the thesis improves an existing algorithm of semantic distance acquisition. Finally, as a novel approach to the extraction of semantic information is proposed, there exists a positive impact on Information Retrieval domain and, specifically, on Natural Language Processing, word disambiguation and Web/Intranet search.
Dimensional Approach to the Study of Sighting Dominance

This study proposes a dimensional and noncategorical approach to research on sighting dominance. Let us suppose that no eye dominance exists as well as results concerning right and left eye dominance. We modified a classical alignment test to measure along a continuum the ocular dominance of 47 female undergraduate students in psychology. Data seem to confirm the hypothesis emphasizing the presence of subjects with no ocular dominance as well as right- and left-dominant subjects. Moreover, another group has been classified. The subjects with fluctuating dominance show an alternation in their dominance. Thus an hypothesis of the functionality of the two hemispheres is suggested.
Alzheimer’s Disease – The Past, the Present and the Future

Alzheimer’s disease (hereafter: AD) is an irreversible, slowly progressive disease of the brain, most often categorized under the umbrella term ‘neurodegeneration’. It is said to be a progressive disease in a sense that the symptoms associated with AD, the most common one being difficulty in remembering recent events, kick in steadily with the symptoms getting worse as time goes on, leading to the demise of affected person as they eventually lose their bodily functions. Other symptoms associated with AD include language problems, mood swings and disorientation. This report seeks to address the history, current as well as the future state of AD by taking into consideration the probable causes and preventive mechanisms together with the treatment methods.
Effects of Group Support Systems and Content Facilitation on Knowledge Acquisition

This paper investigates the effects of group support systems (GSS) and content facilitation on individual knowledge acquisition in general, and on changes in an individual's knowledge structures in particular as indicated through concept mapping development. We present a model explaining the enabling effects of GSS and content facilitation on group processes (group participation, quality of feedback, domination, and communication barrier), cooperation in learning, and individual knowledge structures (knowledge complexity, integration, and commonality). An experiment that employed a 2X2 factorial design was used to explore the main and interaction effects of GSS and content facilitation on knowledge acquisition. Experimental subjects were randomly assigned to one of the four treatment groups; that is, nonfacilitation and non-GSS, nonfacilitation and GSS, facilitation and non-GSS, facilitation and GSS. Results of the experiment indicated that both GSS and content facilitation positively affect certain aspects of individual knowledge acquisition. Content facilitation particularly enhanced learners'knowledge commonality,whereas GSS enhanced the quality of feedback and cooperation in learning, and reduced domination and communication barrier. However, the results also indicated that GSS and content facilitation have crossover interaction effects on group participation and knowledge commonality. The effects of combining GSS and content facilitation were not additive in this study. Explanations are presented.
Gonorrhea screening in an urban hospital Family Planning Program.

The relationship between the incidence of gonorrhea or pelvic inflammatory disease and modern contraceptive methods is questioned in this study. Family planning clinic patients were surveyed for disease and contraceptive method used. It is concluded that no method of contraception - oral contraceptives the IUD injection foam or condoms - seems to be related to the increase in gonorrheal infections though IUD users showed symptoms of pelvic inflammatory disease and gonorrheal infections more often than users of other methods.
Language and thought: empirical and conceptual viewpoints : Language as an emergent function : Some radical neurological and evolutionary implications

Language is a spontaneously evolved emergent adaptation, not a formal computational system. Its structure does not derive from either innate or social instruction but rather self-organization and selection. Its quasi-universal features emerge from the interactions among semiotic constraints, neural processing limitations, and social transmission dynamics. The neurological processing of sentence stricture is more analogous to embryonic differentiation than to algorithmic computation. The biological basis of this unprecedented adaptation is not located in some unique neurological structure nor the result of any single mutation, but is vested in the synergistic interaction of numerous coevolved neurological biases and social dynamics.
Human rpL3 induces G₁/S arrest or apoptosis by modulating p21waf1/cip1 levels in a p53-independent manner

It is now largely accepted that ribosomal proteins may be implicated in a variety of biological functions besides that of components of the translation machinery. Many evidences show that a subset of ribosomal proteins are involved in the regulation of the cell cycle and apoptosis through modulation of p53 activity. In addition, p53-independent mechanisms of cell cycle arrest in response to alterations of ribosomal proteins availability have been described. Here, we identify human rpL3 as a new regulator of cell cycle and apoptosis through positive regulation of p21 expression in a p53-independent system. We demonstrate that the rpL3-mediated p21 upregulation requires the specific interaction between rpL3 and Sp1. Furthermore, in our experimental system, p21 overexpression leads to a dual outcome, activating the G₁/S arrest of the cell cycle or the apoptotic pathway through mitochondria, depending on its intracellular levels. It is noteworthy that depletion of p21 abrogates both effects. Taken together, our findings unravel a novel extraribosomal function of rpL3 and reinforce the proapoptotic role of p21 in addition to its widely reported ability as an inhibitor of cell proliferation.
Passive Continuous Particle Focusing in a Microchannel with Symmetric Sharp Corner Structures

We report a continuous passive particle focusing method using a novel microchannel with symmetric sharp corners which induce curved streamlines and large centrifugal force on particles. At appropriate flow rate, the centrifugal force generated on particles exceeds the inertial lift force; particles driven by the centrifugal force migrate toward the center of the microchannel, achieving continuous particle focusing. With simple structure and operation, this method can be potentially used in particle focusing and extraction processes in a variety of lab-on-a chip applications.
A totally ordered and secure multicast protocol for distributed virtual environment

Sharing a virtual space with many users, a distributed virtual reality environment (DVE) provides high level communication and cooperative design facilities. For a large-scale DVE in a wide area network, a reliable and efficient multicast protocol on the Internet is necessary. We have developed a reliable multicast protocol based on the sequence server and evaluated it using simulation. From the simulation result, our protocol is more scalable than RMP (reliable multicast protocol). However, the protocol has an obvious drawback in that the ordering cost is centralized to the sequence server. Therefore, the scalability and extensibility is limited. Furthermore, security support is not provided. It is an important factor for reality of the DVE system. We propose a method to distribute the workload to some servers to make the protocol scalable and extensile. From our simulation result, the message arrival time to members is drastically reduced. We also propose a key distribution mechanism for secure multicast communication.
Combining Patent Law Expertise with R&D for Patenting Performance

Drawing on the resource-based view (RBV), this paper examines how the combination or bundling of resources influences firm-patenting performance. We hypothesize that firm-patenting output depends not only on research and development (RD furthermore, this effect is moderated by the firm's level of top management team (TMT) patent law background and industry-patenting pressures. However, our hypothesis of a complementary relationship between patent law expertise and RD instead, we found evidence of a counterintuitive (weak) negative interaction between these two variables. Our findings shed light on how the combination of other resources with R&D affects firm-patenting performance, and advance the integration of complementary organizational perspectives with the RBV.
Overexpressed yeast mitochondrial putative RNA helicase Mss116 partially restores proper mtRNA metabolism in strains lacking the Suv3 mtRNA helicase

RNA helicase, encoded by the Saccharomyces cerevisiae nuclear gene SUV3, is a subunit of the mitochondrial (mt) degradosome: an enzyme complex that takes part in turnover of mtRNAs. Deletion of the SUV3 gene leads to a variety of disturbances in mtRNA metabolism and results in respiratory incompetence of yeast cells. Here we show that the nuclear gene MSS116, which codes for a mitochondrial putative RNA helicase necessary for splicing of several mt introns, can suppress the lack of the SUV3 gene. Overexpression of the Mss116 putative helicase from a multicopy plasmid present in the SUV3‐deleted strains partially restores respiratory competence, brings the steady‐state levels of COB and ATP6/8 mRNA back almost to normal and lowers the accumulation of 21S rRNA and ATP6/8 RNA precursors to the wild‐type levels. To the best of our knowledge, this is the first reported case of a substitution of one RNA helicase by another, belonging to a different class of RNA helicases. Copyright © 2002 John Wiley & Sons, Ltd.
Aging Koreans' perceived conflicts in relationships with their offspring as a function of age, gender, cohabitation status, and marital status.

The Youn Scale was used to assess aging Koreans' perceived conflicts in relationships with their adult offspring. The sample consisted of 623 elderly Koreans between the ages of 55 and 84 years. Results indicated that aging Koreans experienced significantly more conflicts in their relationships as they grew older. There were also differences in the perceptions of problems in relationships with their offspring between those who lived together with their adult children and the those who did not, and also between those who were married and those who were single. The findings imply that aging Koreans want to have qualitatively better (i.e., warmer and closer) relationships with their offspring, regardless of their bereavement status and cohabitation status.
Identification of Domain Required for Catalytic Activity of Auxilin in Supporting Clathrin Uncoating by Hsc70*

During clathrin-mediated endocytosis Hsc70, supported by the J-domain protein auxilin, uncoats clathrin-coated vesicles. Auxilin contains both a clathrin-binding domain and a J-domain that binds Hsc70, and it has been suggested that these two domains are both necessary and sufficient for auxilin activity. To test this hypothesis, we created a chimeric protein consisting of the J-domain of auxilin linked to the clathrin-binding domain of the assembly protein AP180. This chimera supported uncoating, but unlike auxilin it acted stoichiometrically rather than catalytically because, like Hsc70, it remained associated with the uncoated clathrin. This observation supports our proposal that Hsc70 chaperones uncoated clathrin by inducing formation of a stable Hsc70-clathrin-AP complex. It also shows that Hsc70 acts by dissociating individual clathrin triskelions rather than cooperatively destabilizing clathrin-coated vesicles. Because the chimera lacks the C-terminal subdomain of the auxilin clathrin-binding domain, it seemed possible that this subdomain is required for auxilin to act catalytically, and indeed its deletion caused auxilin to act stoichiometrically. In contrast, deletion of the N-terminal subdomain weakened auxilin-clathrin binding and prevented auxilin from polymerizing clathrin. Therefore the C-terminal subdomain of the clathrin-binding domain of auxilin is required for auxilin to act catalytically, whereas the N-terminal subdomain strengthens auxilin-clathrin binding.
Évaluation d'outils de reformulation interactive de requêtes

As part of a user modeling and learning information retrieval research, we introduce a new approach of interactive query reformulation modules evaluation considering the search session time. Using an adapted user experimental protocol, we show that effectiveness is very changing for different user search sessions and during a same user search session and thus that suggestion mechanisms cannot be compared globally. In this way, we propose to use a fine analysis of user behavior to segment search session in state which may provide enough information to select the more effective suggestion mechanism. MOTS-CLES : Recherche d’information, Modelisation utilisateur, Retour de pertinence, Reformulation de requetes, Evaluation, Experimentation utilisateur
Méta-évaluation de la traduction automatique de la parole (TAP) dans le domaine médical

L’utilisation de la traduction automatique de la parole (TAP) serait d’un grand secours dans la pratique hospitaliere d’urgence. Nos objectifs sont les suivants : Premierement, proposer une methode qui permet de comparer des systemes de TAP dans le domaine medical de maniere fiable. Deuxiemement, introduire une nouvelle mesure pour la TAP qui serait equivalente a l’utilisation de la methode EAGLES-ISO, mais plus rapide et plus economique a mettre en place. Nous avons par consequent effectue une deuxieme serie d’experiences qui debouche sur une methode d’evaluation alternative. Celle-ci se concentre sur la qualite a l’usage de la TAP produite. Elle est fondee sur l’evaluation humaine mais fait intervenir le crowdsourcing afin d’augmenter l’efficacite, la rapidite et la fiabilite de l’evaluation de la TAP dans le domaine medical tout en comprimant les couts engendres. La methode d’evaluation proposee, qui constitue la principale contribution de ce travail, porte le nom TURKoise.