Miracle-dz/UniFAR-FTUs huggingface dataset:
Quality of life and treatment related toxicity in 335 patients with locally advanced cervical carcinoma treated by two chemoradiation regimens.

PURPOSE Concomitant chemoradiotherapy (CT/RT) is the gold standard for advanced cervical carcinoma, but with frequent debates over treatment schedules and toxicity. This study compared 2 concomitant CT/RT regimens in terms of quality of life (QoL) and acute toxicity. PATIENTS AND METHODS Between March 2003 and March 2005, 335 patients with stage IIB-IIIB cervical carcinoma were evaluated in a randomized single-center phase III trial at the Oncology Institute Cluj-Napoca. Patients received concurrent CT/RT with cisplatin 20 mg/m(2), days 1-5, every 21 days (arm A, n=171) or 40 mg/m(2)/weekly (arm B, n=164). QoL was estimated using the EORTC QLQ-30, v.3. 0 questionnaire and acute toxicity using the common toxicity criteria (CTC) v.2. 0. RESULTS Significant improvement of global health status (p <0.01) and a decrease in pain (p <0.01) was observed in arm A. In arm B fatigue increased (p=0.01) and role functioning diminished (p=0.05). In both arms depression, nausea, vomiting and diarrhea increased (p <0.05). Gastrointestinal toxicity was similar in both arms (76% vs. 77.5%). Hemoglobin drop was higher in arm B: 75% vs. 63% (p=0.02), while no differences were seen in leukocyte and platelet toxicity. CONCLUSION Concomitant CT/RT with cisplatin 20 mg/m(2) x 5 days every 21 days has better impact on patients' QoL and lower toxicity compared with the weekly chemotherapy regimen.
Photoresponsive nanocomposite formed by self-assembly of an azobenzene-modified silane.

Mesoporous materials made by surfactant-directed selfassembly (SDSA) have been of great interest in the past decade because of their potential applications in catalysis, membrane separations, adsorption, and chemical sensing. [1–6] In SDSA, inorganic moieties formed by alkoxide hydrolysis interfacially coorganize with hydrophilic surfactant headgroups to form periodically ordered hybrid mesophases. After condensation and removal of surfactant molecules by heat or solvent extraction, a periodic mesoporous inorganic matrix is created. To expand the range of applications as well as create new properties, various organic functional groups have been covalently incorporated onto the pore surfaces of mesoporous materials, including phenyl, octyl, aminoalkyl, cyanoalkyl, thioloalkyl, epoxyl, and vinyl groups. [6–10] However, to date, these modifications have provided mainly “passive” functionality, such as controlled wetting properties, reduced dielectric constants, or enhanced adsorption of metal ions. By comparison, materials with “active” functionality would enable properties to be dynamically controlled by external stimuli, such as pH, temperature, or light. In an effort to make such active hybrid materials, Ogawa et al. intercalated azobenzene moieties within a clay (magadiite), which resulted in a hybrid layered composite in which restricted photoisomerization caused the d spacing to change reversibly by 0.6 / upon exposure to UV and visible light. [11] Several groups have reported[1213] or suggested the formation of photoactive hybrids through SDSA of azobenzene of pyridylethylene bridged silsesquioxanes. For a lamellar mesostructure, Brinker and co-workers. showed the d spacing to be optically controllable through photoisomerization of the azobenzene moiety before or after self-assembly. Alvaro et al.[13] doped 1,2-bis(4-pyridyl)ethylene in the wall of a hexagonal mesoporous silica and provided preliminary evidence of photoinduced changes in the surface area and pore volume. As shown in Figure 1, the incorporation of covalently bonded “switchable” ligands as pendant groups (as opposed to bridging groups[12–14]) within a porous (rather than a layered[1112]) framework is expected to result in nanocompo-
Using Cardiac Magnetic Resonance Imaging to Evaluate Cardiac Function and Predict Outcomes in Patients with Valvular Heart Disease

Objective In valvular heart disease, elevated left atrial and pulmonary pressures contribute to right ventricular strain and, ultimately, right ventricle failure. Elevated pulmonary artery (PAP) and left ventricular end diastolic pressures are used as markers of right ventricle dysfunction and correlate with poor outcomes. Using cardiac magnetic resonance imaging (CMR), it is possible to directly quantify both left and right ventricular ejection function (LVEF and RVEF), and here, we compare CMR with traditional markers as outcome predictors. Methods A retrospective review of prospectively collected data was performed for patients from January 2004 to February 2008 at a single center (n = 103). Patients were divided into those receiving CMR (n = 56) and those receiving only catheterization (n = 47). Univariate and multivariate logistic regression models were applied to determine predictors of mortality. Finally, predictive models for mortality using PAP, mean PAP, and left ventricular end diastolic pressure were compared to models using LVEF and RVEF obtained from CMR. Results Preoperative average CMR LVEF and RVEF were 57% and 46%, respectively. Only age emerged as an isolated predictor of mortality (P = 0.01) within the univariate models. Stepwise regression models were created using the catheterization or CMR data. When compared, the CMR model has a slightly better R2, c (prediction accuracy), and sensitivity/specificity (0.22 vs 0.28, 0.77 vs 0.82, and 0.63/0.62 vs 0.69/0.64, respectively). Conclusions Within our population, LVEF and RVEF predict mortality as least as well as traditional catheterization values. Additionally, CMR may identify of elevated PAPs caused by right ventricle dysfunction and those due to other causes, allowing these other causes to be addressed preoperatively.
Liberals Think More Analytically (More “WEIRD”) Than Conservatives

Henrich, Heine, and Norenzayan summarized cultural differences in psychology and argued that people from one particular culture are outliers: people from societies that are Western, educated, industrialized, rich, and democratic (WEIRD). This study shows that liberals think WEIRDer than conservatives. In five studies with more than 5,000 participants, we found that liberals think more analytically (an element of WEIRD thought) than moderates and conservatives. Study 3 replicates this finding in the very different political culture of China, although it held only for people in more modernized urban centers. These results suggest that liberals and conservatives in the same country think as if they were from different cultures. Studies 4 to 5 show that briefly training people to think analytically causes them to form more liberal opinions, whereas training them to think holistically causes shifts to more conservative opinions.
Longevity - Can We Afford It? The Problem of Households' Direct Health Care Expenditures in Poland

Longevity can be perceived as increasing life expectancy in a population or as the long lifespan of an individual. Longer lifespans and decreasing fertility rates in many countries will cause societies to rapidly grow old. This paper is an attempt to define the determinants of the ‘out-of-pocket’ medical expenditures of the elderly. In this research statistical tests and micro-econometric modelling were carried out on a sample of the Polish population. The results of the analysis indicate that the elderly with their elevated needs for medical assistance spent more on the health care, than the rest of population (in the absolute value and in relation to income) and that their expenditures are constantly increasing. The main limitation to households’ health care expenditures is the income, which suggests that there may be an unrealized demand for medical services and products, especially medical drugs that cannot be obtained entirely free of charge. This highlights a new direction for the development of Poland’s health care policy; otherwise, longevity may be a luxury that not everyone can afford.
The Effect of Stock Ownership Toward the Corporate Social Responsibility (CSR) Disclosure

This study aims at investigating the effect of stock ownership by foreign parties and government toward the level of corporate social responsibility (CSR) disclosure. The participating companies of Indonesia Sustainability Reporting Awards 2015 were selected as the samples by employing purposive sampling technique. This study employed secondary data from annual report, sustainability report, and financial report. Data were analyzed using simple linear regression analysis. The result shows that government and foreign ownership had no significant influence toward CSR disclosure.
Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells

The use of Cre/loxP recombination in mammalian cells has expanded rapidly. We describe here that Cre expression in cultured mammalian cells may result in a markedly reduced proliferation and that this effect is dependent on the endonuclease activity of Cre. Chromosome analysis after Cre expression revealed numerous chromosomal aberrations and an increased number of sister chromatid exchanges. Titration experiments in mouse embryo fibroblasts with a ligand-regulatable Cre-ERT show that toxicity is dependent on the level of Cre activity. Prolonged, low levels of Cre activity permit recombination without concomitant toxicity. This urges for a careful titration of Cre activity in conditional gene modification in mammalian cells.
Bonded interactions and the crystal chemistry of minerals: a review

Connections established during last century between bond length, radii, bond strength, bond valence and crystal and molecular chemistry are briefly reviewed followed by a survey of the physical properties of the electron density distributions for a variety of minerals and representative molecules, recently generated with first-principles local energy density quantum mechanical methods. The structures for several minerals, geometry-optimized at zero pressure and at a variety of pressures were found to agree with the experimental structures within a few percent. The experimental Si–O bond lengths and the Si–O–Si angle, the Si–O bond energy and the bond critical point properties for crystal quartz are comparable with those calculated for the H6Si2O7 disilicic acid molecule, an indication that the bonded interactions in silica are largely short ranged and local in nature. The topology of model experimental electron density distributions for first and second row metal M atoms bonded to O, determined with high resolution and high energy synchrotron single crystal X-ray diffraction data are compared with the topology of theoretical distributions calculated with first principles methods. As the electron density is progressively accumulated between pairs of bonded atoms, the distributions show that the nuclei are progressively shielded as the bond lengths and the bonded radii of the atoms decrease. Concomitant with the decrease in the M–O bond lengths, the local kinetic energy, G(rc), the local potential energy, V(rc), and the electronic energy density, H(rc) = G(rc) + V(rc), evaluated at the bond critical points, rc, each increases in magnitude with the local potential energy dominating the kinetic energy density in the internuclear region for intermediate and shared interactions. The shorter the bonds, the more negative the local electronic energy density, the greater the stabilization and the greater the shared character of the intermediate and shared bonded interactions. In contrast, the local kinetic energy density increases with decreasing bond length for closed shell interactions with G(rc) dominating V(rc) in the internuclear region, typical of an ionic bond.
Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project.

OBJECT The Glioma Outcomes Project represents a contemporary analysis of the management of malignant (Grade III and Grade IV/GBM) gliomas in North America. This observational database was used to evaluate the influence of resection, as opposed to biopsy, on patient outcome as measured by the length of survival. Attempts were made to reduce the impact of selection bias by repeating the data analysis after omitting patients with major negative prognostic factors. METHODS Outcome data from 788 patients accrued from multiple sites over a 4-year period (1997-2001) were analyzed with the primary outcome measure being length of survival. Of these, 565 patients with recent diagnoses formed the basis of the present analysis. Patients were systematically followed up until death or up to 24 months after enrollment in the study, and survival data were correlated with the histopathological grade and location of the tumor, the extent of surgery, the patient's performance status, and demographic factors. The median length of survival was 40.9 weeks for patients with recently diagnosed GBMs. The true median length of survival for patients with Grade III gliomas was not reached, although there was a 58% survival rate at 104 weeks. In multivariate analysis, resection rather than biopsy (p < 0.0001), age 60 years or younger (p < 0.0001), and a Karnofsky Performance Scale (KPS) score of 70 or greater (p = 0.0004) were associated with a prolonged survival time for patients with Grade III or IV gliomas. The prognostic value of resection compared with biopsy was maintained (p < 0.0001), even after eliminating patients considered to be "poor risk" (those with age > 60 years, KPS score < 70, or presence of multifocal tumors), who may have been overrepresented in the biopsy group. Survival "tails" at 24 months were 58% for Grade III gliomas and 11% for GBMs. CONCLUSIONS These data provide Class II evidence to support tumor grade, patient's age, and patient's functional status as prognostic factors for survival in individuals with recently diagnosed malignant gliomas. Resection (compared with biopsy) is also a strong prognostic factor; however, no quantitative attempt was made to assess the true extent of the resection.
Optimal nonequilibrium driving of a rotary mechanochemical motor

Prompted by current experiments on mechanically driven F1 ATP synthase, we investigate optimal (minimum-dissipation) driving protocols of rotary mechanochemical motors. We propose a simple model system coupling chemical reactions to mechanical motion under periodic boundary conditions, driven by a periodic time-dependent force. Under linear response approximations near equilibrium and near nonequilibrium steady states, optimal driving protocols are determined by a generalized friction coefficient. Such a model has a periodic generalized friction coefficient that peaks near system energy barriers, implying optimal protocols that proceed rapidly when the system is overwhelmingly in a single macrostate, but slow significantly near energy barriers, harnessing thermal fluctuations to kick the system over the energy barriers for free.
Qualitative Assessment of Marketing Factors That Influence Digital Business

The private immanent components of qualitative measurement that influence online retailers management system of marketing commodity policy (MSMCP) are systematized and the architectonics is developed. The latent root causes of the online retailers’ MSMCP formation that determine the private immanent components of qualitative measurement and explain the correlation between the relevant features and their meaningful interpretation are identified. The canonical models for assessing the private immanent components of qualitative measurement that influence online retailers’ MSMCP are developed. The realization of the models is the foundation for generating effective marketing decisions and the achievement of relevant goals through a single managerial impact. The methodical approach to the qualitative assessment marketing factors that influence digital business is justified. The proposals and recommendations for online retailers are developed based on the results of the methodical approach test and validation.
A 19-23 GHz integrated LC-VCO in a production 70 GHz fT SiGe technology

Integrated LC-VCOs for microwave frequencies are widely used nowadays. Traditionally, a lot of attention is paid to optimize the quality factor of the integrated inductor and varactor. The active part of the oscillator, used to undamp the resonator circuit, is often implemented as a cross-coupled differential pair. Even with a near-loss-less resonator circuit, this cross-coupled pair inherently puts a limit to the maximum attainable oscillation frequency. We derive a relation for this maximum attainable frequency f/sub cross/, and demonstrate a 19-23 GHz integrated LC-VCO approaching this theoretical limit for our IC-technology.
Enterprise resource planning and the post bureaucratic organization: "Formalization" as trust in the system versus "solidarity" as trust in individuals

Purpose – The purpose of the paper is to use a case study setting involving the implementation of an enterprise resource planning (ERP) system to expose and analyze the conflicts in the characterizations of the post bureaucratic organisation (PBO) in the literature. ERP implementations are often accompanied by increasing levels of stress in organizations that place pressures on organizational relationships and structures. Additionally, ERPs are regarded as introducing their own techno-logic of centralization, standardization and formalization that provides an apparent contrast to the exhortations about employee empowerment. Design/methodology/approach – A case study of ERP implementation in a medium-sized entity is presented. The paper explores aspects of ERP and PBO from the context of postmodern organization theory. Findings – Some concerns about PBO identified in the literature are reflected in the case situation. For example, there is a commitment to give up private time and work flexibly by some employees. The paper also provides evidence of the way the management team substitute their reliance on a key individual knowledge worker for that of an ERP system and external vendor support. Paradoxically, trust in that same knowledge worker and between core users of the system is essential to enable the implementation of the system. Originality/value – This paper adds empirical insight to a predominantly theoretical literature. The case evidence indicates some conflicting implications in the concurrent adoption of PBO and ERP.
The Effect of Corporate Governance Attributes on Earnings Management: A Study of Listed Companies in Nigeria

Earnings are a fundamental item on the financial statement which also serves as a yardstick for investors and other stakeholders in making an informed decision. It is very important for close attention to be paid to it as regards its management. Hence, the study examined the relationship corporate governance attributes have on earnings management using earnings persistence as a proxy for measuring earning management. The corporate governance attributes are in accordance with CBN code of governances which include ownership structure, audit committee independence and board size. This study made use of Eviews 2017 software to compute the data obtained from the annual reports and financial statement using 44 firms as the sample size of the study. The sample size, however, was derived using random sampling technique across the eleven (11) sectors listed on Nigerian Stock Exchange Market. Based on the findings, corporate governance attributes influences the level of earnings management practised in Nigeria.
Ion exchange recovery of palladium (II) from nitrate weak acidic solutions

Sorption recovery of palladium (II) from nitrate weak acidic model solutions and solutions of spent catalysts on some ion exchangers with different physical and chemical structure has been investigated. The palladium concentration in contacting solutions was 5.0 ? 10-5 – 1.0 ? 10-3 mol/L at nitric acid and potassium nitrate con-centrations 0.01 and 1.0 mol/L, respectively. It was shown that anion exchangers AV-17-8 as well as Purolite S 985 and A 500 possess the best sorption and kinetic properties. These sorbents can be recommended for selective recovery of palladium from solutions of spent catalysts.
Influential Factors of Competitive Advantage Progression on SME Third-Party Logistics in Selangor Malaysia

Small and medium-sized enterprises (SME) of third-party logistics struggle to stay competitive and facing various pressure to stay competitive. One of the tactics to be competitive is to implement effective competitive measures. The purpose of this research was to explore the influential factors of competitive advantage on third-party logistics in Selangor Malaysia. Data collection included semi-structured questionnaires from 370 managers involved in logistics activities from the small and medium-sized enterprise manufacturing industries located in Selangor. Data analysis was used to identify key influential factors of competitive advantage progression. Correlation and regression analysis were conducted to test the research hypotheses. The results reflect that competitive measures needed extensive attention to stay competitive in the market. Thus, third-party logistics needs to cultivate competitive advantage knowledge and other competitive measures that will drive the third-party logistics service uniqueness. The findings may contribute to social change by helping small and medium-sized third-party logistics to improve their survival rate and to create their firm’s sustainable competitive capability and performance and as well provide solutions to challenges facing the third-party logistics.
Equity Incentive and Growth of Executives in Mixed Ownership Enterprises Listed Manufacturing Enterprises Based on State-Owned Holdings

This paper takes the state-owned manufacturing mixed-ownership en-terprises as the research sample, selects the data from 2014-2016, and studies the relationship between executive equity incentives and corporate growth. Firstly, theoretical analysis is carried out according to the existing literature, and then empirical research is carried out by regression analysis on the basis of theoretical analysis. The research shows that: in the state-owned manufacturing industry, in mixed ownership enterprises, there is a positive correlation between executive equity incentives and corporate growth, but this correlation will be affected by equity concentration. Only when the ratio of the largest shareholder is in the range of 20% - 50%, the positive correlation between executive equity incentives and corporate growth is significant. The executive equity incentive policy has not significantly promoted the growth of the company in the enterprises with scattered equity or excessive concentration of equity. Based on this, it is proposed that enterprises should establish a reasonable executive equity incentive policy and further optimize the shareholding structure through the reform of state-owned enterprise mixed ownership.
Design of a Wireless Power Supply Receiver for Biomedical Applications

This paper presents the design and prototype development of a wireless receiver to supply power to biomedical devices used inside the human body. It is designed using the principle of magnetic induction to supply approximately 100 mW of power. Single coil and 3-coil orthogonal configurations are investigated, including simulations in SPICE. Prototype for a single coil receiver was developed and tested, where good correlation between simulation and experimental results was achieved. These initial experiments and prototype have formed the basis for developing a battery-free, miniature power supply system for biomedical devices