Miracle-dz/UniFAR-FTUs huggingface dataset:
Spray drying of liquid extracts of curcumin: process performance and product quality properties

The aim of this work was to evaluate the operation of spray drying to obtain powder curcumin from turmeric extract blended with maltodextrin. An experimental design (central composite design) with two statistical factors was used. These factors were the inlet air temperature (140-160ºC) and outlet air temperature (75-95ºC), with the rotation speed kept constant (28000 RPM). Statistical optimization was established by considering the response surfaces analysis where the hygroscopicity was minimized and the curcumin concentration was maximized. The optimal conditions for the spray drying process were inlet and outlet air temperatures of 149ºC and 75ºC, respectively, at an atomization speed of 28000 RPM. These settings provided the following
A Wage-Efficiency Spatial Model for US Self-Employed Workers

In this paper, we study self-employment in a theoretical setting derived from wage-efficiency spatial models, where leisure and effort at work are complementary. We develop a spatial model of self-employment in which effort at work and commuting are negatively related, and thus the probability of self-employment decreases with "expected" commuting time. We use time-use data from the American Time Use Survey 2003-2014 to analyze the spatial distribution of self-employment across metropolitan areas in the US, focusing on the relationship between commuting time and the probability of self-employment. Our empirical results show that the probability of self-employment is negatively related to the "expected" commuting time, giving empirical support to our theoretical model. Furthermore, we propose a GIS model to show that commuting and self-employment rates are, in relation to unemployment rates, negatively related.
The Obesity Epidemic : Strategies in Reducing Cardiometabolic Risk

The obesity epidemic in the United States represents a critical public health issue that has the potential to incur major healthcare costs because of the substantial risks associated with excess body fat. Whereas many recognize the significant risk of cardiovascular disease and diabetes mellitus associated with excess body fat, a myriad of other health problems can accompany overweight and obesity, potentially leading to early morbidity and mortality. Public recognition of obesity as an important health crisis, and not simply a matter of cosmetics or lifestyle choice, is clearly needed. A greater awareness of the health risks associated with excess weight will facilitate more frequent obesity screenings and discussions about healthy weight management that have the potential to result in a greater commitment of healthcare resources to effective obesity prevention and management strategies. © 2009 Published by Elsevier Inc. • The American Journal of Medicine (2009) 122, S4–S11
Regulators Discover a Hidden Viral Gene in Commercial GMO Crops

In the course of analysis to identify potential allergens in GMO crops, the European Food Safety Authority (EFSA) has belatedly discovered that the most common genetic regulatory sequence in commercial GMOs also encodes a significant fragment of a viral gene (Podevin and du Jardin 2012) [1]. This finding has serious ramifications for crop biotechnology and its regulation, but possibly even greater ones for consumers and farmers. This is because there are clear indications that this viral gene (called Gene VI) might not be safe for human consumption. It also may disturb the normal functioning of crops, including their natural pest resistance.
Design for patients with Gestational Diabetes

6 Chapter 1: Introduction . 7 1.1 Research Questions . 8 1.2 Research Aim . 9 1.3 Structure of thesis.9 Chapter 2: Background . 10 2.1 Human-Computer Interaction . 10 2.2 Role of mHealth in Gestational Diabetes . 11 2.3 Persuasive Technology . 12 2.3.1 Persuasive Conversational Agent . 13 2.3.2 Understanding a Conversational Processes . 16 2.4 Related Work . 17 2.4.1 SelfManagement Applications . 17 2.4. 2 Gamification and Data Visualization . 20 2.4. 3 Summary of Related Work. 21 2.5 Systematic Review and Meta-Analysis . 21 Chapter 3: Methodology . 23 3.1 Design Science Research . 23 3.2 Research through design . 23 3.2.1 Problem Identification . 24 3.2.2 Evaluation of Design . 24 3.3 User-Centered Design . 25 3.4 Prototyping . 26 3.5 Usability Evaluation . 27 3.5. 1 Cognitive Walkthrough . 27 3.5. 2 Think-Aloud Protocol . 28 3.5. 3 Usability Measurement . 29 3.6 Chapter Summary . 29 Chapter 4: Requirement Gathering and Analysis . 30 4.1 Requirement Gathering . 30 4.1.1 Observations . 31 4.1.2 Workshop . 31 4.1.3 Surveys . 32
Modeling the dynamics of soil erosion and size‐selective sediment transport over nonuniform topography in flume‐scale experiments

Soil erosion and the associated nutrient fluxes can lead to severe degradation of surface waters. Given that both sediment transport and nutrient sorption are size selective, it is important to predict the particle size distribution (PSD) as well as the total amount of sediment being eroded. In this paper, a finite volume implementation of the Hairsine‐Rose soil erosion model is used to simulate flume‐scale experiments with detailed observations of soil erosion and sediment transport dynamics. The numerical implementation allows us to account for the effects of soil surface microtopography (measured using close range photogrammetry) on soil erosion. An in‐depth discussion of the model parameters and the constraints is presented. The model reproduces the dynamics of sediment concentration and PSD well, although some discrepancies can be observed. The calibrated parameters are also consistent with independent data in the literature and physical reason. Spatial variations in the suspended and deposited sediment and an analysis of model sensitivity highlight the value of collecting distributed data for a more robust validation of the model and to enhance parametric determinacy. The related issues of spatial resolution and scale in erosion prediction are briefly discussed.
Molecular and Cellular Pathobiology Nitric Oxide – Dependent Downregulation of BRCA 1 Expression Promotes Genetic Instability

Elevated levels of nitric oxide (NO) and reactive nitrogen species (RNS)may link inflammation to the initiation, promotion, and progression of cancer. Traditionally, this link has been thought to be mediated by the effects of NO/RNS in generating DNA damage. However, this damage also stimulates DNA repair responses with subsequent blocks to cell proliferation and apoptosis, thereby preventing accumulation of NO/RNS-generated mutations. In addressing this conundrum, I describe here an alternative mechanism for understanding mutagenesis by NO/RNS. Moderate NO/RNS concentrations stimulated mutagenesis not directly by generating DNA damage but indirectly by modifying the activities of DNA repair and genome stability factors without affecting cell proliferation. NO/RNS at concentrations physiologically relevant to inflammation stimulated PP2A activity, leading to dephosphorylation of RBL2, its accumulation in the nucleus, and formation of RBL2/E2F4 complexes. RBL2/E2F4 formation in turn led to a shift in BRCA1 promoter occupancy from complexes containing activator E2F1 to complexes containing repressor E2F4, downregulating BRCA1 expression. By inhibiting BRCA1 expression, NO/RNS thereby reduces the ability of cells to repair DNA double-strand breaks through homologous recombination repair, increasing the involvement of error-prone nonhomologous end joining (NHEJ). In summary, NO/RNS stimulates genetic instability by inhibiting BRCA1 expression and shifting DNA repair from high fidelity to error-prone mechanisms. Cancer Res; 73(2); 706–15. 2012 AACR.
The ecology of wildlife disease surveillance: demographic and prevalence fluctuations undermine surveillance

1. Wildlife disease surveillance is the first line of defence against infectious disease. Fluctuations in host populations and disease prevalence are a known feature of wildlife disease systems. However, the impact of such heterogeneities on the performance of surveillance is currently poorly understood. 2. We present the first systematic exploration of the effects of fluctuations prevalence and host population size on the efficacy of wildlife disease surveillance systems. In this study efficacy is measured in terms of ability to estimate long term prevalence and detect disease risk. 3. Our results suggest that for many wildlife disease systems fluctuations in population size and disease lead to bias in surveillance-based estimates of prevalence and over-confidence in assessments of both the precision of prevalence estimates and the power to detect disease. 4. Neglecting such ecological effects may lead to poorly designed surveillance and ultimately to incorrect assessments of the risks posed by disease in wildlife. This will be most problematic in systems where prevalence fluctuations are large and disease fade-outs occur. Such fluctuations are determined by the interaction of demography and disease dynamics and although particularly likely in highly fluctuating populations typical of fecund short lived hosts, can’t be ruled out in more stable populations of longer lived hosts. 5. Synthesis and Applications: Fluctuations in population size and disease prevalence should be considered in the design and implementation of wildlife disease surveillance and the framework presented here provides a template for conducting suitable power calculations. Ultimately understanding the impact of fluctuations in demographic and epidemiological processes will enable improvements to wildlife disease surveillance systems leading to better characterisation of, and protection against endemic, emerging and re-emerging disease threats.
Changes of the dynamic properties of films based on carrageenan by microcapsules incorporation

The use of edible films for covering food matrices has been of great importance due to they protect and extend the shelf life of different foods. The aim of this paper was to determinate the rheological changes caused by microcapsules incorporation on edible films made from carrageenan. All rheological measurements were carried out in the viscoelastic zone, which was determined using the Kelvin–Voigt model. Both films (with and without microcapsules) presented predominantly elastic characteristics (G′ > G′′). The microcapsules addition decreased the recovery values as a result of a film-degradation structure. The relaxation time ranged between 9.245 x 10 to 9.427 x 10 s and the instantaneous compliance (J0) values were 88.51 times higher than the retarded compliance (J1) values in the studied films indicating the loss of elasticity of the films due to microcapsules incorporation.
Increasing Silage Levels in Dairy Diets Using Starch and NDF Digestibility Data

As economic challenges evolve in the dairy industry, improvements are required in how cows are fed to maintain profitability. One strategy to reduce feed costs is to increase corn silage levels in diets and remove corn grain. This is particularly effective when corn is expensive relative to corn silage. However, high corn silage diets can produce variable results due to potential variation in the ruminal digestion of starch and fiber, which can negatively impact dry matter intake (DMI) and resulting performance (Allen, 2000; Allen et al., 2009).
GREEN INFRASTRUCTURE: A STRATEGIC TOOL FOR CLIMATE CHANGE MITIGATION IN URBAN ENVIRONMENTS

The changing climate has a significant negative impact on urban environments, influencing thereby the quality of life of urban residents and causing a range of problems in urban areas worldwide. There is a need for efficient urban planning and design tools, which can mitigate these negative effects. Green infrastructure represents a tool to create more resilient and sustainable urban environments by greening open spaces in our cities. Green structures and greenery elements improve the urban microclimate and reduce noise, dustiness, the heat island effect and help to manage urban stormwater. Therefore, it is crucial to protect and improve existing green spaces, enhance their connectedness and utilise unconventional areas for creating new green spaces which would improve the health of urban landscapes. Here, greening of roofs, walls, brownfields and other empty spaces comes into play. They still represent an unutilised potential of contemporary urban landscapes. Landscape Architecture as a field of research and design practice plays a crucial role in developing innovative tools, planning and designing green infrastructure which will contribute to creation of sustainable and multifunctional urban landscapes of the future.
Animal transgenesis in biomedical application - a review.

Transgenesis is radically a new technology for altering the characteristics of animals by directly changing the genetic material. There has been rapid development in the use of genetically engineered animals as investigators have found an increasing number of applications for the technology. Transgenic technology holds great potential in agriculture, medicine and industry. This article lays emphasis on the Bio-medical applications of transgenesis.
Running title : Pseudomonas fluorescens PICF 7-assisted barley production Pseudomonas fluorescens PICF 7 displays endophytic lifestyle in cultivated cereals and enhances yield in barley

Pseudomonas fluorescens PICF7, an indigenous olive roots inhabitant, displays endophytic lifestyle in this woody crop and exerts biocontrol against the fungal phytopathogen Verticillium dahliae. Here we report microscopy evidence that the strain PICF7 is also able to colonize and persist on/in wheat and barley root tissues. Root colonization of both cereal species followed a similar pattern to that previously reported in olive, including inner colonization of the root hairs. This demonstrates that strain PICF7 can colonize root systems of distant botanical species. Barley plants germinated from PICF7-treated seeds showed enhanced vegetative growth. Moreover, significant increases in the number of grains (up to 19.5%) and grain weight (up to 20.5%) per plant were at U niersite L aval on M ay 2, 2016 ht://fem sec.oxfournals. org/ D ow nladed from scored in this species. In contrast, growth and yield were not significantly affected in wheat plants by the presence of PICF7. Proteomics analysis of the root systems revealed that different proteins were exclusively found depending on the presence or absence of PICF7 and only one protein with hydrogen ion transmembrane transporter activity was exclusively found in both PICF7-inoculated barley and wheat plants but not in the controls.
Scientific wisdom and know-how ( a ) The question of the regional maximum earthquake

Since the catastrophic Sumatra–Andaman tsunami took place in 2004, 16 other tsunamis have resulted in significant damage and 14 in casualties. We review the fundamental changes that have affected our command of tsunami issues as scientists, engineers and decisionmakers, in the quest for improved wisdom in this respect. While several scientific paradigms have had to be altered or abandoned, new algorithms, e.g. the W seismic phase and real-time processing of fastarriving seismic P waves, give us more powerful tools to estimate in real time the tsunamigenic character of an earthquake. We assign to each event a ‘wisdom index’ based on the warning issued (or not) during the event, and on the response of the population. While this approach is admittedly subjective, it clearly shows several robust trends: (i) we have made significant progress in our command of far-field warning, with only three casualties in the past 10 years; (ii) self-evacuation by educated populations in the near field is a key element of successful tsunami mitigation; (iii) there remains a significant cacophony between the scientific community and decisionmakers in industry and government as documented during the 2010 Maule and 2011 Tohoku events; and (iv) the so-called ‘tsunami earthquakes’ generating larger tsunamis than expected from the size of their seismic source persist as a fundamental challenge, despite scientific progress towards characterizing these events in real time.
Cultural Patterns and Subjective Culture as Predictors of Well-Being: A Cross-Cultural Study

Every culture has its paradise vision: desirable and external conditions which, inside the concerned culture, are infrequently observed or difficult to realize and are linked to one another. This cross-cultural study compares well-being in China, Bulgaria, France and Germany. The cultural patterns of the culture are differently, but well-being is easier to achieve if people adapt to their cultural patterns. The adjustment (positive subjective culture) is formed by culture-specific content and needs different in regards to different cultures.
Keynan 842 CLINICAL SYNDROMES Bacteremia and Endocarditis

Enterococci, formerly called group D streptococci, have become resistant to many antibiotic agents, including vancomycin. Vancomycin-resistant enterococci (VRE) infections are increasingly common and difficult to treat, appearing usually as longlasting hospital outbreaks that present tremendous challenges for infection control. Enterococci are equipped with a variety of intrinsic (ie, naturally occurring) antibiotic resistances, but are also capable of acquiring new resistance genes and/or mutations. The combination of high-level resistance to ampicillin, vancomycin, and aminoglycosides is now common with hospital-acquired Enterococcus faecium. The major infections caused by enterococci in general and VRE in particular include urinary tract infections (UTI), wound infections, intraabdominal infections secondary to a perforated viscous or after surgery, cholecystitis, bacteremia, endocarditis, and rarely meningitis. UTI can be cured with a single (bacteriostatic) agent whereas bacteremia, endocarditis, and meningitis require a bactericidal agent or drug combination. Some acute infections due to VRE may be treated to resolution, although in some cases colonization may persist indefinitely.
N Basaran of male rats after birth in the comet and TUNEL assays-hexyl phthalate possess genotoxic effects on testicular cells n In utero exposure to dicyclohexyl

Phthalates are diester derivatives of phthalic acid widely used in many commercial applications. The aim of this study is therefore to evaluate possible genotoxicity of di-n-hexyl phthalate (DHP) and dicyclohexyl phthalate (DCHP) at different concentrations using single-cell gel electrophoresis (comet) and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end-labeling (TUNEL) assays in testes samples of male rat pups. DCHP and DHP in corn oil were administered to the pregnant rats by gavage at the doses of 0 (vehicle), 20, 100, and 500 mg kg 1 day 1 from gestational day 6 (GD6) to GD19. After delivery, male rats were allowed to grow until prepubertal, pubertal, and adulthood. At necropsy, the blood samples were collected from heart and were excised immediately. The apoptotic cells of prepubertal, pubertal, and adult testis were detected using TUNEL assay. The comet assay was performed on blood lymphocytes and testes samples of adult male rats. The comet assay results showed that tail length, tail intensity, olive tail moment (OTM), and percentage of DNA present in tail were higher when DHP content was increased. Judging from the values of OTM and percentage of DNA, DHP could significantly induce DNA breakage at doses of 100 and 500 mg kg 1 day 1 compared with the control group. An increase in TUNEL-positive cells of prepubertal, pubertal, and adult testicular cells was observed in the treated groups. In conclusion, prenatal exposure to DHP and DCHP may possess genotoxic risk to testicular cells of rats at all stages of development, even at adulthood.
Synthesis and Characterization of Nitrogen-Doped TiO2/WO3 Nano-Composite Material and its Photocatalytic Activity for Photo-degradation of Phenol Red in Aqueous Solution

Crystal form of N-TiO2/WO3 Nano-Composite material was prepared from urea, commercial TiO2 and WO3 by simple solid phase reaction followed by calcinations at a temperature of 400 °C for four hours at each step. The as-synthesized photocatalyst was characterized using XRD and Uv-Visible diffuse reflectance spectra. It was found that the absorption edge of N-TiO2/WO3 was well extended to visible light. Dark experiment has been done to know the degree of photodegradation of adsorption of PR over the studied photocatalyst under non-irradiation. The result obtained was for photocatalytic degradation of adsorbed PR was only about 6.32%. The as-synthesized photocatalyst was highly active under visible irradiation (93.87%) than under UV irradiations (75.74%). This may be due to the fact that the absorption edge of the modified TiO2 particle shifts to visible light range.
Tobias identical binding mechanism distinct clades of HIV-1 gp 120 by an A cryptic polyreactive antibody recognizes

Polyreactive antibodies play an important role for neutralization of human immunodeficiency virus (HIV). In addition to intrinsically polyreactive antibodies, the immune repertoires of healthy individuals contain antibodies with cryptic polyreactivity. These antibodies acquire promiscuous antigen binding potential posttranslationally, after exposure to various redoxactive substances, such as reactive oxygen species, iron ions and heme. Here, we characterized the interaction of a prototypic human antibody that acquires binding potential to gp120 after exposure to heme. The kinetic and thermodynamic analyses of interaction of the polyreactive antibody with distinct clades of gp120, demonstrated that the antigen-binding promiscuity of the antibody compensates for the molecular heterogeneity of the target antigen. Thus, the polyreactive antibody recognized divergent gp120 clades with similar values of the binding kinetics and quantitatively http://www.jbc. org/cgi/doi/10.1074/jbc.M114.556266 The latest version is at JBC Papers in Press. Published on May 6, 2014 as Manuscript M114.556266 Copyright 2014 by The American Society for Biochemistry and Molecular Biology, Inc. at B A L L ST A T E U N IV on N ovem er 0, 2014 hp://w w w . jb.org/ D ow nladed from
Title : The jasmonic acid signaling pathway is linked to auxin homeostasis through the modulation of YUCCA 8 and YUCCA 9 gene expression Running title : Oxylipin-induced auxin biosynthesis

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as an 'Accepted Article', doi: 10.1111/tpj.12152 © 2013 The Authors. The Plant Journal © 2013 Blackwell Publishing Ltd Received Date : 14-Sep-2011 Revised Date : 24-Jan-2013 Accepted Date : 12-Feb-2013 Article type : Original Article Title: The jasmonic acid signaling pathway is linked to auxin homeostasis through the modulation of YUCCA8 and YUCCA9 gene expression
Oxygen uptake rate (OUR) control strategy for improving avermectin B 1a production during fed-batch fermentation on industrial scale (150 m 3 )

Glucose metabolism plays a crucial role in the process of avermectin B 1a biosynthesis. Controlling glucose feeding based on oxygen uptake rate (OUR) was established to improve the efficiency of avermectin B 1a production. The result showed that avermectin B 1a production was greatly enhanced by OUR control strategy. In the glucose feeding phase, OUR was maintained at approximate 12 mmol/L/h, which was conducive to avermectin B 1a biosynthesis. Using this OUR control strategy, an adequate supply of organic acid precursors produced avermectin B 1a 5228 U/mL, which was 22.8% higher than that of the control (batch fermentation, 4256 U/mL) on industrial scale.