Miracle-dz/UniFAR-FTUs huggingface dataset:
In-Vehicle Situation Monitoring for Potential Threats Detection Based on Smartphone Sensors

This paper presents an analysis of modern research related to potential threats in a vehicle cabin, which is based on situation monitoring during vehicle control and the interaction of the driver with intelligent transportation systems (ITS). In the modern world, such systems enable the detection of potentially dangerous situations on the road, reducing accident probability. However, at the same time, such systems increase vulnerabilities in vehicles and can be sources of different threats. In this paper, we consider the primary information flows between the driver, vehicle, and infrastructure in modern ITS, and identify possible threats related to these entities. We define threat classes related to vehicle control and discuss which of them can be detected by smartphone sensors. We present a case study that supports our findings and shows the main use cases for threat identification using smartphone sensors: Drowsiness, distraction, unfastened belt, eating, drinking, and smartphone use.
Towards incorporating anamorphic fungi in a natural classification – checklist and notes for 2011

A complilation of anamorphic names for both Ascomycota and Basidiomycota is provided which comprises 2895 genera. The genera are listed against a backbone of teleomorphic relationships where known. The study reveals that 73 genera and 95 anamorph-like genera are linked to teleomorphic genera names, 447 genera (three anamorph-like genera) are linked to teleomorph families, orders or classes, while for more than 1592 (55%) genera no teleomorph link is known. The links are based on the literature and often because fungi were found in association, but have not been proven by molecular data. Many are based on links with species other than the generic type and thus must be considered questionable for the genus. A considerable effort is needed to establish whether these links are correct.
Changes in serum thyroid hormone levels in psychiatric patients treated with second-generation antipsychotics.

INTRODUCTION The objective of the study was to evaluate changes in serum thyroid hormone levels in psychiatric patients after second-generation antipsychotic (SGA) treatment, and to determine differences between monotherapy and polytherapy with SGAs, as well as differences between patients with and without a history of antipsychotics. MATERIAL AND METHODS A total of 71 patients with baseline thyroid hormone levels within the normal reference ranges were included in this retrospectively study. RESULTS After SGAs treatment, the serum levels of free triiodothyronine (FT3), free thyroxine (FT4), total triiodothyronine (TT3), and total thyroxine (TT4) significantly decreased, and serum thyroid-stimulating hormone (TSH) levels significantly increased (changes from baseline: FT3: -0.31 pmol/L, p < 0.001; FT4: -2.71 pmol/L, p < 0.001; TT3: -0.05 nmol/L, p = 0.024, TT4: -12.36 nmol/L, p < 0.001; TSH: 0.46 mIU/L, p < 0.001). One (1.4%) patient had TSH levels higher than 7 mIU/L. Changes in serum levels of TSH and TT3 between patients with or without a history of antipsychotic drugs were significantly different (changes from baseline: TSH: p < 0.001 vs. p = 0.089; TT3: p = 0.013 vs. p = 0.553). Changes in serum TSH levels had a moderate positive correlation with the average daily dose of SGAs (p = 0.007, r = 0.318). CONCLUSIONS After SGA treatment, patients seemed to have a trend of hypothyroidism, but the incidence was low. The preliminary results of this study did not show the necessity of regular monitoring of serum thyroid hormone levels in patients with baseline thyroid hormone levels within the normal reference ranges.
Absolute and relative growth of Douglas-fir seedlings of different sizes

: Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco) seedlings of a single seed source were grown in a bare-root nursery for two years to produce five different stock types by varying spacing and transplanting treatments. They were then planted in the forest together with one-year-old container seedlings of the same seed source, which constituted a sixth treatment. Stem volume mean relative growth rate (R(v)) was low immediately after planting for all stock types except the container seedlings, and increased over the following 7.6 years. An 8-week greenhouse test of the six stock types showed that dry weight mean relative growth rate (R(w)) generally decreased with seedling dry weight, but this effect was less obvious after planting, because only the three smaller stock types showed a decrease in R(w) with size. In another experiment, bare-root Douglas-fir seedlings were grown at five different spacings in a nursery for two years, and seedlings from each spacing treatment were sorted into large or small by height. The resulting 10 treatments were planted in the forest and stem volumes determined over 6.7 years. The linear effect of nursery spacing on stem volume was no longer evident 3.6 years after planting, but large seedlings had greater stem volume than the small seedlings throughout the 6.7 years of the study. There was no indication that R(v) declined with time, but small seedlings had higher R(v) than large seedlings. Relative growth rates of two-year-old Douglas-fir were depressed for a year or two after planting, but then remained relatively constant, or increased during the ensuing 5 years. Relative growth rates of smaller seedlings were greater than those of larger seedlings so that relative biomass differences decreased with time, and the time advantage (the time necessary for small seedlings to reach the present biomass of large stock) of larger stock decreased. Absolute size differences increased with time.
Cognitive bias in emergency medicine

Cognitive bias is ‘a systematic pattern of deviation from norm or rationality in judgement’. Individual biases are common thought patterns that distort our perceptions, leading to incorrect or inaccurate judgements. Heuristics are shortcuts we subconsciously apply to complex situations to aid decision-making, which can make us susceptible to cognitive bias. Despite being common, most people are largely unaware of their cognitive biases. Cognitive biases are ubiquitous and do not correlate with intelligence. Causes are varied and include learned and innate biases, cultural biases and a lack of appreciation of statistics. Biases can be considered rational deviations from logical thought rather than illogical errors. Using a sailing analogy, bias is the wind blowing the sailboat off course, whereas the truth or reality is the direction straight ahead. Dual Process Theory describes how the brain makes decisions in one of two modes: through fast, subconscious, intuitive processes (system 1) or through slower, conscious, analytical processes (system 2). Cognitive biases are predominantly located in the intuitive mode where we spend most of our conscious time.
Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes

Significance This study describes the discovery of a class of drug that can help the immune system eliminate hard-to-kill cells infected with HIV. HIV establishes a persistent infection for which there is no cure, necessitating the development of new approaches to enhance the clearance of HIV-infected cells. HIV encodes Nef, which down-regulates MHC-I expression in infected cells to impair immune-mediated clearance by cytotoxic T lymphocytes. We identified the plecomacrolide family of natural products as potent inhibitors of Nef, and concanamycin A restored MHC-I and enhanced the clearance of HIV-infected primary cells by cytotoxic T lymphocytes. Concanamycin A counteracted Nef from diverse clades of HIV targeting multiple allotypes of MHC-I, indicating the potential for broad therapeutic utility. Nef is an HIV-encoded accessory protein that enhances pathogenicity by down-regulating major histocompatibility class I (MHC-I) expression to evade killing by cytotoxic T lymphocytes (CTLs). A potent Nef inhibitor that restores MHC-I is needed to promote immune-mediated clearance of HIV-infected cells. We discovered that the plecomacrolide family of natural products restored MHC-I to the surface of Nef-expressing primary cells with variable potency. Concanamycin A (CMA) counteracted Nef at subnanomolar concentrations that did not interfere with lysosomal acidification or degradation and were nontoxic in primary cell cultures. CMA specifically reversed Nef-mediated down-regulation of MHC-I, but not CD4, and cells treated with CMA showed reduced formation of the Nef:MHC-I:AP-1 complex required for MHC-I down-regulation. CMA restored expression of diverse allotypes of MHC-I in Nef-expressing cells and inhibited Nef alleles from divergent clades of HIV and simian immunodeficiency virus, including from primary patient isolates. Lastly, we found that restoration of MHC-I in HIV-infected cells was accompanied by enhanced CTL-mediated clearance of infected cells comparable to genetic deletion of Nef. Thus, we propose CMA as a lead compound for therapeutic inhibition of Nef to enhance immune-mediated clearance of HIV-infected cells.
Seasonal changes in mass and histology of the spleen in Willow Tits Parus montanus

Seasonal changes in the mass and histology of the spleen of juvenile and adult Willow Tits Parus montanus throughout the year were examined. The results showed that the avian spleen is a highly dynamic structure able to undergo dramatic changes in size, mainly due to changes in the volumes of the lymphoid components. Twelve-day-old nestlings had small undifferentiated spleens with no germinal centres (GCs), but consisted of a homogeneous lymphocyte-containing tissue. One-month-old Willow Tits (July) had significantly heavier spleens than any other age group. Their spleens had a well developed red pulp and large numbers of small GCs and intensely basophilic cells (IBCs), probably reflecting an increased antibody production initiated by exposure to new antigens. The question why not all young tits develop large active spleens at this time is discussed, and it is suggested that the lymphoid activity of the spleen might be a factor of importance for successful establishment in an autumn/ winter flock. Adult birds had small spleens in July. Although there was a very large inter-individual variation, most adult and juvenile tits had very big spleens in August and September, a period when tits are moulting and finishing flock establishment. This inter-individual variation most likely reflects differences in degree of infections. It is hypothesised that a large spleen, with a high lymphoid activity, in a moulting bird is the result of growing feather follicles being broken, and that the resulting wounds have become infected. Once moult and flock establishment are finished (October), spleens in both age groups remain small until next spring, containing few or no GCs and only weakly developed IBCs and red pulp. Small spleens during late autumn and winter may reflect low parasite infections or a high sensitivity to stress.
Clinical efficacy and imaging evaluation of recombinant tissue plasminogen activator thrombolytic therapy in patients with wake up stroke

Abstract Introduction: Wake up stroke starts in sleep and is a more common form of ischemic stroke. At present, it is still controversial whether wake up stroke can be treated with thrombolytic therapy. Therefore, this study will combine imaging techniques to assess the onset time of wake up stroke patients, and to analyze the imaging characteristics of wake up stroke patients and patients suitable for thrombolytic therapy within the time window. Methods/design: This study will be a single-blinded, randomized controlled trial with 2 parallel groups. It will be conducted at North China University of science and technology affiliated hospital. Discussion: There is no consistent conclusion about the pathogenesis of wake up stroke. Wake up stroke is more likely to manifest as small vessel disease. The incidence of wake up stroke patients is relatively high, and the effectiveness and safety of intravenous thrombolysis under the guidance of multimode imaging therapy in wake up stroke need to be further explored by prospective, large-scale studies. Trial registration: ClinicalTrials.gov, ChiCTR2000034402, Registered on 05 July 2020
Impact of triglyceride playing on stroke severity correlated to bilirubin

Abstract Major lipids making effects on the occurrence of acute ischemic stroke (AIS) is well recognized, but their roles on stroke severity remain uncertain. To explore the exact roles of lipids playing on stroke severity and the possible mechanism, we conduct this observational study. Data was collected from patients with AIS from February 2008 to May 2012. The level of major lipids was compared among AIS groups with different severity and investigated the correlation. Also, the relationship existed between major lipids and bilirubin. Mechanism of major lipids playing on stroke severity was researched to determine if oxidative stress reflected by bilirubin. Lower triglyceride (TG) and higher high density lipoprotein cholesterol (HDL-C) were observed in severe stroke, and obvious correlation existed between TG and stroke severity or HDL-C and stroke severity. TG was associated negatively with direct bilirubin (DBIL) and total bilirubin (TBIL), and lower level of DBIL and TBIL were related to higher quartiles of TG. There was no obvious difference of DBIL and TBIL among the groups of quartiles of HDL-C. TG was the influence factor of stroke severity in severe stroke through multiple univariable logistic regression. But it was not the independent influence factor after multivariable logistic regression adjusted by DBIL or TBIL. However, HDL-C was the influence factor of stroke severity through both univariable and multivariable logistic regression. Lower TG or higher HDL-C predicted severer stroke. The effect of TG on stroke severity was mediated by bilirubin, not HDL-C.
Preliminary study on the anti-apoptotic mechanism of Astragaloside IV on radiation-induced brain cells

With multiple targets and low cytotoxicity, natural medicines can be used as potential neuroprotective agents. The increase in oxidative stress levels and inflammatory responses in the brain caused by radiation affects cognitive function and neuronal structure, and ultimately leads to abnormal changes in neurogenesis, differentiation, and apoptosis. Astragaloside Ⅳ (AS-Ⅳ), one of the main active constituents of astragalus, is known for its antioxidant, antihypertensive, antidiabetic, anti-infarction, anti-inflammatory, anti-apoptotic and wound healing, angiogenesis, and other protective effects. In this study, the mechanism of AS-IV against radiation-induced apoptosis of brain cells in vitro and in vivo was explored by radiation modeling, which provided a theoretical basis for the development of anti-radiation Chinese herbal active molecules and brain health products. In order to study the protective mechanism of AS-IV on radiation-induced brain cell apoptosis in mice, the paper constructed a radiation-induced brain cell apoptosis model, using TUNEL staining, flow cytometry, Western blotting to analyze AS-IV resistance mechanism to radiation-induced brain cell apoptosis. The results of TUNEL staining and flow cytometry showed that the apoptosis rate of radiation group was significantly increased. The results of Western blotting indicated that the expression levels of p-JNK, p-p38, p53, Caspase-9 and Caspase-3 protein, and the ratio of Bax to Bcl-2 in radiation group were significantly increased. There was no significant difference in the expression levels of JNK and p38. After AS-IV treatment, the apoptosis was reduced and the expression of apoptosis related proteins was changed. These data suggested that AS-IV can effectively reduce radiation-induced apoptosis of brain cells, and its mechanism may be related to the phosphorylation regulation of JNK-p38.
Prognosis of Early-Stage Hepatocellular Carcinoma: Comparison between Trans-Arterial Chemoembolization and Radiofrequency Ablation

Simple Summary Radiofrequency ablation (RFA) is a curative treatment for early-stage hepatocellular carcinoma (HCC) ineligible for surgery or liver transplantation. However, trans-arterial chemoembolization (TACE) might be an alternative when RFA is contraindicated due to structural problems. Among treatment-naive HCC patients fulfilling the Milan criteria who underwent RFA (n = 136) or TACE (n = 268), complete response (CR) and 5-year recurrence-free survival (RFS) rates were higher in the RFA group than in the TACE group (94.1% vs. 71.6% and 35.8% vs. 17.0%, respectively; both p < 0.001), whereas 5-year overall survival (OS) rates were not significantly different (65.5% vs. 72.3%, respectively; p = 0.100). After propensity-score matching, similar results were also reproduced. Hence, TACE could be an effective alternative to RFA in terms of OS rates. However, TACE should be confined only to RFA-difficult cases, given its lower CR and RFS rates and multi-disciplinary approaches are desirable in decision-making. Abstract Radiofrequency ablation (RFA) is a curative treatment for early-stage hepatocellular carcinoma (HCC) ineligible for surgery or liver transplantation. However, trans-arterial chemoembolization (TACE) might be an alternative when RFA is contraindicated due to structural problems. Here, we aimed to compare their long-term outcomes. Treatment-naive HCC patients fulfilling the Milan criteria who underwent RFA (n = 136) or TACE (n = 268) were enrolled. Complete response (CR) and 5-year recurrence-free survival (RFS) rates were higher in the RFA group than in the TACE group (94.1% vs. 71.6% and 35.8% vs. 17.0%, respectively; both p < 0.001), whereas 5-year overall survival (OS) rates were not significantly different (65.5% vs. 72.3%, respectively; p = 0.100). Multivariate analysis showed that RFA was associated with better RFS (adjusted hazard ratio [aHR] 0.628; p = 0.001) than TACE, but not with better OS (aHR 1.325; p = 0.151). The most common 1st-line treatment after recurrence were TACE (n = 53), followed by RFA (n = 21) among the RFA group and TACE (n = 150), followed by RFA (n = 44) among the TACE group. After propensity-score matching, similar results were reproduced. Hence, TACE could be an effective alternative to RFA in terms of OS rates. However, TACE should be confined only to RFA-difficult cases, given its lower CR and RFS rates and multi-disciplinary approaches are desirable in decision-making.
What Has a Century of Quantitative Genetics Taught Us About Nature's Genetic Toolkit?

The complexity of heredity has been appreciated for decades: Many traits are controlled not by a single genetic locus but instead by polymorphisms throughout the genome. The importance of complex traits in biology and medicine has motivated diverse approaches to understanding their detailed genetic bases. Here, we focus on recent systematic studies, many in budding yeast, which have revealed that large numbers of all kinds of molecular variation, from noncoding to synonymous variants, can make significant contributions to phenotype. Variants can affect different traits in opposing directions, and their contributions can be modified by both the environment and the epigenetic state of the cell. The integration of prospective (synthesizing and analyzing variants) and retrospective (examining standing variation) approaches promises to reveal how natural selection shapes quantitative traits. Only by comprehensively understanding nature's genetic tool kit can we predict how phenotypes arise from the complex ensembles of genetic variants in living organisms. Expected final online publication date for the Annual Review of Genetics, Volume 54 is November 23, 2020. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Trade-Offs in Choice.

To explain trade-offs in choice, researchers have proposed myriad phenomena and decision rules, each paired with separate theories and idiosyncratic vocabularies. Yet most choice problems are ultimately resolved with one of just two types of solutions: mixed or extreme. For example, people adopt mixed solutions for resolving trade-offs when they allow exercising to license indulgence afterward (balancing between goals), read different literary genres (variety seeking), and order medium-sized coffees (the compromise effect). By contrast, when people adopt extreme solutions for resolving these exact same trade-offs, they exhibit highlighting, consistency seeking, and compromise avoidance, respectively. Our review of the choice literature first illustrates how many seemingly unrelated phenomena actually share the same underlying psychology. We then identify variables that promote one solution versus the other. These variables, in turn, systematically influence which of opposite choice effects arise (e.g., highlighting versus balancing). Finally, we demonstrate how several mistakes people purport to make can potentially instead be reinterpreted as mixed solutions for resolving trade-offs. We conclude with guidance for distinguishing mistakes from mixed solutions. Expected final online publication date for the Annual Review of Psychology, Volume 72 is January 4, 2021. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Age-related similarities and differences in the components of semantic fluency: analyzing the originality and organization of retrieval from long-term memory

ABSTRACT The present study investigated age-related differences in retrieval from long-term memory using a semantic fluency task in which participants recalled animals during a 5-minute retrieval period. We evaluated the relative uniqueness of items and their output position within the retrieval process to further elucidate how younger and older adults access and retrieve semantic knowledge in long-term memory. Although older (n = 96, aged 56-79, M = 62.44) and younger adults (n = 98, aged 18-27, M = 23.44) scored similarly for retrieval fluency and originality, these abilities tended to decline when we analyzed age as a continuous variable, indicating some preservation in earlier adulthood, but impairment in older age. Additionally, participants tended to recall common, more easily accessible items before unique, less accessible items, and this pattern was more prominent in older adults. Thus, there are both similarities and differences in semantic fluency in older age.
Correlation between the Crosslink Characteristics and Mechanical Properties of Natural Rubber Compound via Accelerators and Reinforcement

The extreme elasticity and reversible deformability of rubber, which is one of the most versatile polymers in modern society, is dependent on several factors, including the processing conditions, curing system, and types of additives used. Since the rubber’s mechanical properties are influenced by the existing structural crosslinks, their correlation with the crosslink characteristics of rubber was investigated using the equilibrium swelling theory of the Flory–Rehner equation and the rubber–filler interaction theory of the Kraus equation. Herein, we examined whether the accelerator and reinforcement agent quantitatively contributed to chemical cross-linkages and rubber–filler interaction. In conclusion, the accelerator content supported the chemically crosslinked structures of the monosulfides and the disulfides in natural rubber (NR). Additionally, these results demonstrated that the mechanical properties and the thermal resistance of NR were dependent on the crosslink characteristics. The findings of this study provide an insight into the development and application of NR products for the mechanical optimization of rubber-based products.