Miracle-dz/UniFAR-FTUs huggingface dataset:
'Rush' type retinopathy of prematurity: report of three cases.

Three premature infants observed to develop severe stage III retinopathy of prematurity (ROP) at 3 to 5 weeks of age received immediate treatment by cryoablation and photocoagulation, with good results. The critical importance of the ophthalmic examination of premature babies from the age of 2 weeks, so as not to overlook such cases of 'rush' type ROP is stressed and the difficulty involved in treating such small neonates is discussed.
Gating of skeletal and cardiac muscle sodium channels in mammalian cells

1 Sodium channel ionic current (INa) and gating current (Ig) were compared for rat skeletal (rSkM1) and human heart Na+ channels (hH1a) heterologously expressed in cultured mammalian cells at ∼13 °C before and after modification by site‐3 toxins (Anthopleurin A and Anthopleurin B). 2 For hH1a Na+ channels there was a concordance between the half‐points (V½) of the peak conductance‐voltage (G–V) relationship and the gating charge‐voltage (Q–V) relationship with no significant difference in half‐points. In contrast, the half‐point of the Q–V relationship for rSkM1 Na+ channels was shifted to more negative potentials compared with its G–V relationship with a significant difference in the half‐points of −8 mV. 3 Site‐3 toxins slowed the decay of INa in response to step depolarizations for both rSkM1 and hH1a Na+ channels. The half‐point of the G–V relationship in rSkM1 Na+ channels was shifted by −8.0 mV while toxin modification of hH1a Na+ channels produced a smaller hyperpolarizing shift of the V½ by −3.7 mV. 4 Site‐3 toxins reduced maximal gating charge (Qmax) by 33% in rSkM1 and by 31% in hH1a, but produced only minor changes in the half‐points and slope factors of their Q–V relationships. In contrast to measurements in control solutions, after modification by site‐3 toxin the half‐points of the G–V and the Q–V relationships for rSkM1 Na+ channels demonstrated a concordance similar to that for hH1a. 5 Q max vs. G max for rSkM1 and hH1a Na+ channels exhibited linear relationships with almost identical slopes, as would be expected if the number of electronic charges (e−) per channel was comparable. 6 We conclude that the faster kinetics in rSkM1 channels compared with hH1a channels may arise from inherently faster rate transitions in skeletal muscle Na+ channels, and not from major differences in the voltage dependence of the channel transitions.
Creativity and Education.

This paper starts with a brief background of the link between creativity and education, including the beginning of the most recent interest in the two. There is a short summary of the reasons for this renewed interest. This is followed by a discussion into the dissatisfactions over current education and its changing role in the light of increasing importance being accorded to creativity. Lastly, evidence in educational policy documents from around the world is presented to show the steps being taken for implementation of creativity in education.
A UML Based System Level Failure Rate Assessment Technique for SoC Designs

This paper proposes an analytical method to assess soft-error rate (SER) in the early stages of a system-on-chip (SoC) platform-based design methodology. The proposed method uses an executable UML model of the SoC for its input. Soft-errors on the design are modeled by disturbances on the value of attributes in the classes of the UML model and disturbances on opcodes of software cores. SER and execution time of each core in the SoC and a failure modes and effects analysis (FMEA) that determines the severity of each failure mode in the SoC are used to compute the system-failure rate (SFR) of the SoC
Disruption of Vitamin E and Butylated Hydroxytoluene Antioxidant Function in Response to Paraquat-Induced Chromosomal Damage in Cultured Anuran Leukocytes

Researchers have reported that the phenolic antioxidants vitamin E and butylated hydroxyltoluene (BHT) effect on cultured cells and human low-density lipoprotein is disrupted by various synthetic chemical compounds and Cu2+ involved in reactive oxygen species (ROS) generation by redox reaction. In this paper, information involved in prooxidative action of vitamin E and BHT in cultured anuran leukocytes is provided in attempt to clarify such disruption mechanisms of antioxidant function.
ERP-based Speller with a New Paradigm

In most implementation of an ERP-based speller, standard row-column paradigm (RCP) was used. However, RCP is susceptible to adjacency-distraction errors because items in the same row or column of the target flash at the time of a half when the target item flashes. The adjacency-distraction errors could be reduced if the number of flanking items that flash with the target is diminished. This study presents a novel P300-based stimulus presentation called row-column-diagonal paradigm (RCDP) where characters on the main diagonal and the anti-diagonal in the matrix flash in addition to characters on the row and columns. In RCDP, items in the same row, column, main diagonal, and anti-diagonal of the target flashes at the time of a quarter when the target item flashes. Using a 6×6 matrix of alphanumeric characters and keyboard commands, ten college students used RCP and RCDP. Stepwise linear discriminant analysis (SWLDA) for the EEG signals recorded in calibration phases was used to calculate discrimininant function. By applying the discrimininant function to electroencephalography (EEG) signal recorded in the test phase, the probability whether the item was the target or not was evaluated. Average accuracy was 76.6% in RCP while 84.0% in RCDP. With RCP, most errors were occurred in the same row or column of the target; on the other hand, with RCDP in the same row, column, main diagonal, or anti-diagonal of the target. These findings indicate how RCDP reduces adjacency-distraction errors and might be able to contribute to develop more advanced stimulus presentation paradigm.
A 2 V, 600 mA, 1 GHz, BiCMOS super-regenerative receiver

The high-volume demand for wireless short-distance data exchange components, in applications such as home automation, robotics, computer peripherals or biomedicine, requires an electronic board with a small number of electronic components and an optimized cost for the receiver chip. The use of two batteries implies a 2 to 3.2 V operating voltage and a low-power consumption. Current solutions, generally based on conversion systems, like 0-IF or low-IF receivers, are penalized by power consumption, minimum operating voltage and the number of external components, especially expensive IF filters. This receiver is based on super-regeneration. Due to the simplicity of the circuit, a 2 V, 1.2 mW chip is integrated on a 6 GHz 0.8 /spl mu/m BiCMOS technology, the external components being limited to two inductors and one varicap diode for center frequency control.
Equity in the delivery of health care in Sweden

There is mutual agreement that health care should be delivered according to need. In this article, although we employ different specifications for need, we conclude that there is inequity in the delivery of health care in Sweden. Higher income groups visit doctors more often than lower income groups in relation to need, but lower income groups remain in hospital longer once they have been admitted. These findings may be interpreted to mean that lower income groups, for various reasons, wait too long before visiting a doctor for a specific disease, the consequence being that the disease is so serious by the time the doctor is contacted that inpatient care and a longer time in hospital are necessary. The policy implication of this situation is that lower patient fees and/or higher incomes may help to reduce the inequities in health care.
Targeted HER2 Treatment in Advanced Gastric Cancer

Amplification of the HER2 gene and over-expression of the HER2 protein in gastric cancer have been shown in a large number of studies. HER2 positivity can be detected in approximately 20% of patients, which is a characteristic associated with poor prognosis. Preclinical in vitro and in vivo studies have demonstrated that both trastuzumab and lapatinib are effective in different gastric cancer models and have thus lead to the initiation of clinical studies. In the first phase III study, the ToGA trial, HER2-positive patients with advanced gastroesophageal and gastric adenocarcinoma were randomized to receive 5-fluorouracil/capecitabine and cisplatin either alone or in combination with trastuzumab. A statically significant gain in overall survival was seen in the patients who received the combined treatment of trastuzumab and chemotherapy. It is expected that the encouraging results from the ToGA trial will have an immediate impact on the management of patients and that routine HER2 testing of patients with advanced gastric cancer will be initiated within a relatively short period of time.
“A hard day’s night?” The effects of Compressed Working Week interventions on the health and work-life balance of shift workers: a systematic review

Objective: To systematically review studies of the effects of the Compressed Working Week on the health and work-life balance of shift workers, and to identify any differential impacts by socio-economic group. Methods: Systematic review. Following QUORUM guidelines, published or unpublished experimental and quasi-experimental studies were identified. Data were sourced from 27 electronic databases, websites, bibliographies, and expert contacts. Results: Fourty observational studies were found. The majority of studies only measured self-reported outcomes and the methodological quality of the included studies was not very high. Interventions did not always improve the health of shift workers, but in the five prospective studies with a control group, there were no detrimental effects on self-reported health. However, work-life balance was generally improved. No studies reported differential impacts by socio-economic group; however, most of the studies were conducted on homogeneous populations. Conclusion: This review suggests that the Compressed Working Week can improve work-life balance, and that it may do so with a low risk of adverse health or organisational effects. However, better designed studies that measure objective health outcomes are needed.
Toxicité cardiaque du trastuzmab chez les patientes atteintes d'un cancer du sein entre 2005 et 2010 à la clinique Sainte Clotilde, La Réunion

Le Trastuzumab est un anticorps monoclonal ciblant le recepteur HER2 surexprime dans environ 20% des cancers du sein et associe a un pronostic defavorable. Ce traitement a un benefice net en termes de survie globale et sans recidive. Son principal effet indesirable est une cardiotoxicite. A l'ile de La Reunion, ce produit est largement utilise. Les Reunionnaises se distinguent des metropolitaines par l'apparition d'un cancer du sein plus precoce et une surproportion en facteurs de risque cardiovasculaire. En tenant compte de ces specificites, ce traitement reste-t-il benefique aux Reunionnaises ? Pour evaluer la tolerance cardiaque chez nos patientes, nous avons realise une cohorte retrospective type expose / non expose au Trastuzumab sur des patientes diagnostiquees entre 2005 et 2010 a la Clinique Sainte Clotilde. L'etude a montre que celles exposees au Trastuzumab avait 2,5 fois plus de chance que les non exposees de voir leur FEVG baisser de plus de dix points (p < 0,01) et que cette baisse survenait essentiellement dans les 12 premiers mois (p < 0,01). Apres arret du traitement, la cardiotoxicite semblait reversible chez la plupart de nos patientes (p=0,05). Nous n'avons pas pu determiner l'influence de la surproportion des FDRCV sur cette toxicite du fait d'un effectif trop faible. Une etude a plus grande echelle semble indispensable pour etayer notre propos mais l'utilisation du Trastuzumab parait favorable aux Reunionnaises.
A Study of the Affective Tutoring System for Music Appreciation Curriculum at the Junior High School Level

This study used quasi-experimental research with sixty people as experimental samples. The entire experimental period lasted for six weeks. The experimental instruments are ARCS Motivation Scale, Learning Effect Rating Scale and Music Appreciation Test Papers for students. The results show that applying ATS to music appreciation curriculum in junior high school can effectively promote learning motivation and learning effectiveness. Also, ATS is highly correlated with learning motivation and learning effectiveness. By learning through ATS, the learners can automatically show interests in music appreciation in daily lives and broaden aesthetic experiences in art and culture. In addition, feasible suggestions in future practice and research would be proposed on the basis of findings.
Formation of Tumor Cell-lined Vascular Spaces : Implications for Rational Design of Antiangiogenic Therapies 1

Here we report that B16F10 murine melanoma cells mimic endothelial cell behavior and the angiogenic process in vitro and in vivo. Cord formation in vitro by tumor cells is stimulated by hypoxia and vascular endothelial growth factor (VEGF) and inhibited by antibodies against VEGF and the VEGF KDR receptor (VEGF receptor 2). We define regulation of tumor cell-derived vascular space formation by these vasoactive compounds as “vasocrine” stimulation. ICRF 159 (Razoxane; NSC 129943) prevents tumor cell but not endothelial cell cord formation in vitro, and the antiangiogenic drug TNP-470 (NSC 642492) inhibits endothelial but not tumor cell cord formation in vitro. Both drugs inhibit formation of blood-filled vascular spaces in vivo. These results bear on the anticipated action of ICRF 159 in human clinical trials and novel strategies for targeting tumor blood supplies.
Diagnosis framework for locating failed segments of path delay faults

Diagnosis tools can be used to speed up the process for finding the root causes of functional or performance problems in a VLSI circuit. In this paper, we proposed a method to locate possible segments that cause extra delays on circuit paths. We use the delay bounds of the tested paths to build linear constraints. By guiding the solutions of the above linear constraints with a linear programming solver, we can identify segments with extra delays. Also, with the ranks of segment delays, we can prioritize the search for possible locations of failed segments. In the diagnosis framework, we also propose to reduce the search space by identifying indistinguishable segments. Essentially, we cannot separate segments in the same category no matter which segments have faults. This approach greatly increases the efficiency of the diagnosis process. In the experimental results, for most cases of injecting 10% of the longest paths delays, the probabilities are over 90% for locating faulty segments within the list of top-ten candidates, and the average rankings are among the top 5 suspect locations
KV-Direct: High-Performance In-Memory Key-Value Store with Programmable NIC

Performance of in-memory key-value store (KVS) continues to be of great importance as modern KVS goes beyond the traditional object-caching workload and becomes a key infrastructure to support distributed main-memory computation in data centers. Recent years have witnessed a rapid increase of network bandwidth in data centers, shifting the bottleneck of most KVS from the network to the CPU. RDMA-capable NIC partly alleviates the problem, but the primitives provided by RDMA abstraction are rather limited. Meanwhile, programmable NICs become available in data centers, enabling in-network processing. In this paper, we present KV-Direct, a high performance KVS that leverages programmable NIC to extend RDMA primitives and enable remote direct key-value access to the main host memory. We develop several novel techniques to maximize the throughput and hide the latency of the PCIe connection between the NIC and the host memory, which becomes the new bottleneck. Combined, these mechanisms allow a single NIC KV-Direct to achieve up to 180 M key-value operations per second, equivalent to the throughput of tens of CPU cores. Compared with CPU based KVS implementation, KV-Direct improves power efficiency by 3x, while keeping tail latency below 10 μs. Moreover, KV-Direct can achieve near linear scalability with multiple NICs. With 10 programmable NIC cards in a commodity server, we achieve 1.22 billion KV operations per second, which is almost an order-of-magnitude improvement over existing systems, setting a new milestone for a general-purpose in-memory key-value store.
Transcutaneous electrical nerve stimulation (TENS): the effect of electrode placement upon cutaneous blood flow and skin temperature.

In the current study the effect of electrode placement on cutaneous blood flow and skin temperature were assessed using laser Doppler flowmetry. Following approval from the University's ethical committee, 30 subjects were recruited (15 male: 15 female) and randomly assigned to a control or one of two treatment groups (n=10 all groups). TENS was applied either over the median nerve or to the Hegyu acupuncture point (L.I.4) for 15 minutes. Blood flow and skin temperature data were recorded during TENS and for 15 minutes post TENS. Analysis of results showed significant differences between groups for cutaneous blood flow (p=0.0001; repeated measures ANOVA). There was a significant increase in blood flow in the TENS median nerve group compared with the other two groups during TENS application. No significant changes in skin temperature were observed between groups. This study demonstrates that the effect of TENS upon cutaneous blood flow is dependent upon electrode placement sites.
Pbx1 is required for adult subventricular zone neurogenesis

TALE-homeodomain proteins function as components of heteromeric complexes that contain one member each of the PBC and MEIS/PREP subclasses. We recently showed that MEIS2 cooperates with the neurogenic transcription factor PAX6 in the control of adult subventricular zone (SVZ) neurogenesis in rodents. Expression of the PBC protein PBX1 in the SVZ has been reported, but its functional role(s) has not been investigated. Using a genetic loss-of-function mouse model, we now show that Pbx1 is an early regulator of SVZ neurogenesis. Targeted deletion of Pbx1 by retroviral transduction of Cre recombinase into Pbx2-deficient SVZ stem and progenitor cells carrying floxed alleles of Pbx1 significantly reduced the production of neurons and increased the generation of oligodendrocytes. Loss of Pbx1 expression in neuronally committed neuroblasts in the rostral migratory stream in a Pbx2 null background, by contrast, severely compromised cell survival. By chromatin immunoprecipitation from endogenous tissues or isolated cells, we further detected PBX1 binding to known regulatory regions of the neuron-specific genes Dcx and Th days or even weeks before the respective genes are expressed during the normal program of SVZ neurogenesis, suggesting that PBX1 might act as a priming factor to mark these genes for subsequent activation. Collectively, our results establish that PBX1 regulates adult neural cell fate determination in a manner beyond that of its heterodimerization partner MEIS2. Highlighted article: The TALE-homeodomain protein PBX1 promotes neural as opposed to oligodendroglial fate in adult mouse neural stem cells, as well as the long-term survival of newborn neurons.
Tradeoff Between Low-Power Operation and Radiation Hardness of Fully Depleted SOI pMOSFET by Changing LDD Conditions

The interrelation between off-leakage as consideration of low-power operation and X-ray radiation hardness has been evaluated in view of optimizing the lightly doped drain (LDD) concentration of fully depleted silicon-on-insulator pMOSFET. The MOSFET with relatively low LDD concentration called ultralow-power P channel LDD (ULP-PLDD) shows a lower off-leakage of 0.1 pA/μm but limited X-ray radiation tolerance, such that the drain current is reduced by ~80% after 112-kGy(Si) X-ray irradiation due to radiation-induced gate length modulation (RIGLEM), while the MOSFET with six times higher LDD concentration called radiation-hardened PLDD (RH-PLDD) shows much higher radiation tolerance that the drain current reduction is ~20% for the same radiation dose because of RIGLEM improvement by the elimination of the offset structure employed in ULP-PLDD. The off-leakage of RH-PLDD is one order of magnitude higher than that of ULP-PLDD as <;1 pA/μm. It is shown that there is such a tradeoff between low-power operation and radiation hardness.
Highly compact impulse UWB transmitter for high-resolution movement detection

In this paper the hybrid integration of an FCC-compliant fifth-order Gaussian derivative impulse generator IC together with a compact ultra-wideband Vivaldi antenna is presented. The setup results in a compact FCC-compliant impulse UWB transmitter. Measurements of the impulse shape in time and spectral domain are shown. With this transmitter a movement detection and the precise measurement of the movement deviation value by a correlation measurement technique is presented. This shows the ability of the UWB radar system to operate as a movement detection sensor. The measurements include a breath rate measurement of a human being.
Multi-objective hypergraph partitioning algorithms for cut and maximum subdomain degree minimization

In this paper we present a family of multi-objective hypergraph partitioning algorithms based on the multilevel paradigm, which are capable of producing solutions in which both the cut and the maximum subdomain degree are simultaneously minimized. This type of partitionings are critical for existing and emerging applications in VLSI CAD as they allow to both minimize and evenly distribute the interconnects across the physical devices. Our experimental evaluation on the ISPD98 benchmark show that our algorithms produce solutions that when compared against those produced by hMETiS have a maximum subdomain degree that is reduced by up to 35% while achieving comparable quality in terms of cut.
LA ADQUISICIÓN DEL ARTÍCULO ESPAÑOL POR PARTE DE LOS COREANOS

A la hora de acercarnos a los resultados de los experimentos en los que se intenta aclarar la adquisicion del lenguaje no nativo, comprobamos que muchos que aprenden una L2 no llegan al logro final que equivaldra a la competencia linguistica de un nativo. Ademas, segun los diferentes grupos de Ll , los sujetos muestran su dificultad en diferentes aspectos de la misma L2. En Fernandez Lopez (1991) se analizan los tipos de errores, segun grupos de Ll (japones, arabe, aleman y frances) que pertenecen al mismo nivel de espanol. Nos fijamos en que el porcentaje de errores sobre el articulo es del 20% en el grupo japones, y en los demas grupos es de un 3,4%. En palabras de Fernandez Lopez, "en el caso del grupo japones, parece ser que se trata de un error con tendencia a fosilizarse. " No seria desacertado suponer que este mismo resultado se obtendra en el grupo coreano. Los coreanos, como los japoneses, tienen la mayor dificultad gramatical en el uso del articulo debido a que el coreano y el japones -ambas lenguas pertenecientes al mismo tronco linguisticono disponen de ninguna categoria equivalente al articulo espanol. Por lo tanto, en nuestra opinion, resulta imprescindible investigar de manera profunda por que los coreanos tienen dificultad en adquirir dicha categoria gramatical o como la perciben ellos en el proceso de adquisicion. Desde el punto de vista pedagogico, intentaremos encontrar algunas soluciones para afrontar este problema en el proceso del aprendizaje.