Miracle-dz/UniFAR-FTUs huggingface dataset:
Encouraging Effects of Ethacrynic Acid Derivatives Possessing a Privileged α, β-Unsaturated Carbonyl Structure Scaffold

α, β-unsaturated carbonyl group is attractive to medicinal chemists due to its peculiar chemical properties and biological activities. It carries out Michael addition reactions with cysteine residues in ATPbinding pocket [1]. Although prominent progress has been made on these compounds with α, β-unsaturated carbonyl group, more efforts are ongoing to discover new compounds with potent biological activities. In the development of ErbB inhibitors, the introduction of an acrylamide fragment on a heterocyclic scaffold of a reversible EGFR/ErbB-2 conjugate produces irreversible ErbB inhibitors [2] such as Canertinib (Figure 1). Afatinib (Figure 1), an ATP-competitive anilinoquinazoline derivative, harbors a reactive acrylamide group and can block enzymatically active ErbB receptor family members irreversibly. It binds to the target leading to the inhibition of ErbB-4 [3]. Ibrutinib (Figure 1) is a potent inhibitor which can covalently bind to Cys481 amino acid of Bruton’s tyrosine kinase (BTK) enzyme [4]. It has been found to inhibit many processes such as tumor-cell migration, ERK signaling and NF-κB DNA binding [5] in preclinical studies. Some small molecule inhibitors of HER2 tyrosine kinase exhibit activity in the populations of trastuzumab-resistant breast cancer including Neratinib [6] (Figure 1). Except α, β-unsaturated carbonyl group, a lot of alternative electrophilic groups has been investigated including butynamides, vinylsulfonamides, and epoxides [7] but with lower reactivity. Therefore, in order to develop more effectively bioactive new compounds, we should pay more attention to α, β-unsaturated carbonyl group.
Enhancement of throughput of DEEC routing protocol in WSN

A WSN is composed of a large number of sensor nodes which consist of sensing, data processing, and communication capabilities. Fault-free and trustworthy data transfer amongst source and destination is the challenges in WSN. The energy efficiency in WSN is a key essential element for improved communication. It is believed that 70% of the energy is used up in data transmission only. The lifespan of the WSN diminishes due to additional energy consumption. Routing protocols as long as providing an optimum data transmission route as of sensor nodes to sink node to save energy of nodes in the system network. Data collection shows a significant part in energy preservation of sensor network. In wireless sensor network energy is mostly used up for three purposes – signal processing, data transmission, and hardware operation. To make the most of the network lifespan data transmission is augmented by applying energy-efficient and reliable routing protocols. The protocols have more traffic overhead and more energy consumption. This thesis proposed enhanced energy efficiency in DEEC routing protocol. The experiment results represented that it also reduced the traffic of the WSN and increases the overall system performance.
An efficient and Secure AMDMM routing protocol in MANET

— MANET is an important field in wireless network. Lot of work has been done in this field but only few techniques presented good efficiency and secured communication. This paper presents a complete scenario on how the data can be secured while it is being routed over an Ad-hoc network. For implementing the same a protocol named as AMDMM is employed along with a security technique to encrypt the data while it is travelling across the network.
Rapid Identification of Clinically Important Aerobic Microorganisms by Automated Blood Culture System and their Antimicrobial Resistance Pattern at Tertiary Care Hospital at Western Rajasthan India

The rapid identification of clinically important microorganisms from positive blood culture provides important diagnostic and therapeutic information. Blood stream infections can lead to life threatening sepsis, require rapid diagnosis and rapid antimicrobial treatment. Aim of our study was isolation and identification of aerobic pathogens causing bacteremia & septicemias and their antibiotic resistance patterns in a tertiary care hospital western Rajasthan. 628 blood samples collected from clinically suspected cases of bacteremia and septicemias were studied by (BacT/ALERT) automated blood culture system. The isolates were identified by standard phenotypic methods and antimicrobial resistance patterns were determined by CLSI guidelines. Positive blood cultures were obtained in 182 (28.9%) of cases. Among gram positive Staph aureus (39.5%) whereas gram negative Klebsiella (16.48%) were predominant isolates, and 3.8% were Candida species. Among staph aureus methicilin among klebsiella cefixime and among pseudomonas ticarcilline was the most resistance drug. The prevalence of MRSA,VRSA and VRE were 86.1%, 9.7% and 50% respectively. Overall high positive rates of blood culture were observed. Rapid isolation of pathogens by automated blood culture system provide early and appropriate treatment to seriously ill patients leading to reduce mortality and duration of hospital stay.
Data Management and Deployment of Cloud Applications in Financial Institutions and its Adoption Challenges

The Cloud has become a new vehicle for delivering resources such as computing and storage to customers on demand. Rather than being a new technology in itself, the cloud is a new business model wrapped around new technologies such as server Virtualization that take advantage of economies of scale and multi-tenancy to reduce the cost of using information technology resources. From one perspective, cloud computing is nothing new because it uses approaches, concepts, and best practices that have already been established. From another perspective, everything is new because cloud computing changes how we invent, develop, deploy, scale, update, maintains, and pay for applications and the infrastructure on which they run. Nonetheless, there exist an increasing number of large companies that are offering cloud computing infrastructure products and services that do not entirely resemble the visions of these individual component topics. The challenge of building consistent, available, and scalable data management systems capable of serving petabytes of data for millions of users has confronted the data management research community as well as large internet enterprises. Financial institutions are not strangers to cloud computing adoption. One of the earlier cloud uses in banks and financial institutions were for SaaS deployments, which allowed for more social media banking. However, now FI's face the issue of security due to the increased number of data leaks. As a result, cloud within IT strategies and architecture for FIs will increase the risk of a security breach among servers and networks unless there is an adoption of a multiyear cloud strategy to keep data protected. This paper highlights the data management in cloud applications and deployments of various services of cloud computing in Financial Institutions with the study of risk factors in the deployment of transaction data of Financial Institutions on clouds.
Study on preterm pre mature rupture of membrane with special reference to maternal and its fetal outcome

Background: To study see maternal and fetal outcome in preterm pre mature rupture of membrane. To reach consciousness how early PPROM cases could be terminated with least morbidity to the mother and fetus Methods: The study conducted in Department of Obstetrics and Gynecology, Katihar Medical College and Hospital, Bihar between November 2013 to august 2015. Sixty Pregnant mothers attended and admitted through antenatal clinic OPD and Emergency with complaining PPROM Result: Over all age range of mothers was (18 to 38) years and over. Over all mean of parity of mothers was 0.87±1.2 birth . The Morbidity exceeded to 46 (76.67%) when the duration of PROM was more than 24 hours. As the Duration of PROM was 12-24 hrs and more the effect on consequences had been disastrous on new born. Mean of weight at birth was 1730.0±516.5gm and Median (Min-Max.) weight was (1000 - 3000) gm. There was 100% morbidity and mortality in gestational age group of 24- 26 weeks in mothers while as gestational age increases the morbidly and mortality decreases. The morbidity and mortality of newly born babies was maximum in cord compression followed by very low birth weight. Conclusions: Preterm prelabour of the fetal membranes contributes to one-third of all preterm births. Conservative management to prolong gestation should be performed in the absence of evidence of infection. There is currently no evidence regarding the risks and benefits of prolongation of gestation beyond 34 weeks gestation.
SCALABLE AND RELIABLE APPROACH FOR HIGH DATA AVAILABILITY IN SERVICE ORIENTED COMPUTING ENVIRONMENT AND RESULT ANALYSIS

:- Service-Oriented Computing (SOC) is increasing as a accepted for developing distributed functions, having scalable, reliable, and sturdy service discovery mechanism could also be a significant issue of utilizing SOC. In recent years, the service discovery ways in which for large scalable service system, centralized collections are used this can suffer from issues like performance susceptibility and bottleneck or traffic jam to failures. We introduced and proposed a peer-to-peer based decentralized service discovery paths view to be the foremost natural because of address the higher than issues and accomplish scalable, reliable and durable service discovery. This paper has proposed Chord4S, a peer-to-peer based approach for decentralized service discovery. To improve data availability, Chord4S distributes the descriptions of functionally equivalent services. Chord4S supports QoS aware service discovery and service discovery with wildcard(s).
Parasitic Microstrip Patch Antenna with Enhanced Bandwidth

This paper presents the design and simulation of parasitic microstrip patch antenna with enhanced bandwidth. The microstrip patch antenna becomes very popular day by day because of its ease of analysis low cost, light weight, easy to feed and their attractive characteristics. The bandwidth obtained by the proposed antenna structure is about 58.10%. The antenna is thin and compact which makes it easily portable. A maximum gain of 4dB achieved at 2.88GHz frequency. The VSWR parameter was found to be less than 2 within the operating frequency range. The substrate material with relative permittivity of 4.2 and loss tangent of 0.0013 is used in this proposed antenna. The total simulation is done on IE3D software. KeywordsGround Plane,IE3D,Microstrip Antenna, parasitic patch, Single Frequency Band.
SECURE FILE KEY SHARING OVER SINGLE IMAGE ON CLOUD COMPUTING

-Cloud computing is a model of internet based computing where the resources like a storage space, online software are provided. IAAS - Infrastructure as a Service is one of the cloud service to users for outsourcing and retrieve data from anywhere in the world. When a cloud user outsources the data on cloud security is provided for preventing data manipulation or data access by unauthorized users. The TEES is time consuming and also there is a chance the cloud service provider might access those files which stored in cloud server because both the encrypted file and correspondent key and file indexes are stored in cloud server. Avoid these problems this system introduces storage nodes for storing file indexes and encrypted files and cloud server stores files keys. When a cloud user upload file then file index is generated automatically and file encrypted by using AES algorithm with generated key. After the key is converted into image as key image and source images by using visual cryptography scheme. The encrypted file and the file indexes are stored in storage node, key source image is stored in cloud server and key image is passed to file owner. Whenever file owner or file users want to download or access files then perform search and then put key image as a input. If it is valid then original key is displayed then again enter this key, after that file is decrypted then downloaded. Thus the proposed project not only reduces the computation time but also provides high security for files on cloud.
AN ANALOG INTERFACE CIRCUIT FOR PIEZORESISTIVE ACCELEROMETER USING CHOPPER STABILIZATION TECHNIQUE

The use of Micro Electro Mechanical systems (MEMS) in today’s application is widely accepted mainly because of low cost and low size. The output comes out from the sensors used inside the MEMS systems is usually an analog output. The analog output from the MEMS systems are very difficult to use in many applications used in today’s world because many of the applications such as cellular phones, and other electronic devices uses digital format. To convert these analog signals to digital format analog to digital converter (ADC) are used. To carry these signals to the ADC we need some interfacing circuits. These interfacing circuits play a major role in MEMS devices. Due to its miniature size it is easily affected by noise and DC offset. Therefore the designing of the interface circuits should be carefully done. This paper presents an interface circuit designed for piezoresistive accelerometer outputs. The interface is designed based on chopper stabilization technique. Chopper stabilized amplification techniques are best known noise reduction techniques used in interfacing techniques. The Auto-zeroing technique previously used uses the sampling method which is used mainly for offset correction but less effect on noise. But the noise reduction in chopper stabilization technique is 33% more than the Auto-zeroing technique.
THE EFFECT OF MARKET ORIENTATION AND COMPETITIVE STRATEGY ON MARKETING PERFORMANCE A SURVEY ON FURNITURE PRODUCT INDUSTRY IN WEST JAVA, INDONESIA

Low marketing performance of furniture products companies is indicated with the achievement of sales targets which is still hard, the low level of profits, and low growth in the number of customers. It is presumably because competitive strategy that has not been appropriate as well as weaknesses in the developing market orientation. The research objective is to assess the influence of market orientation and competitive strategy on marketing performance of furniture products industry in West Java. The nature of the study is causalities. The unit of analysis is furniture industry and the observation unit is the merchant of furniture products businesses in International Journal of Economics, Commerce and Management, United Kingdom Licensed under Creative Common Page 275 West Java. Based on data owned by the Ministry of Industry 2014 known the number of furniture businesses/entrepreneurs either from wood or rattan totaled 392. Based on Slovin’s formula, obtained a sample size of 80 respondents. The observation time using the coverage time (time horizon) that is cross section/one shoot means that information or data is collected directly and empirically at one particular time. To examine the relationship between variables is used Partial Least Square. The findings reveals that market orientation and competitive strategy are influential to marketing performance, which is competitive strategy has a greater influence than market orientation in affecting marketing performance.
English to Malay ( Bahasa Melayu ) Translation : Syntactical Issues Involving Time Reference

For speakers of other languages who are interested in learning Bahasa Melayu, English has always been a useful tool to understand Bahasa Melayu easily as English is internationally well-know and widely used language and is also comparable with Bahasa Melayu. Unlike English, Bahasa Melayu does not have various types of tenses to indicate what happened in the past, in the present or in the future time. Bahasa Melayu however has its own unique way to show different aspects of time reference such as by adding the word ‘telah’ for past events and ‘akan’ for future events. This is actually one of the problems faced by Bahasa Melayu learners when constructing sentences to refer to various aspects of time reference. Thus, this study seeks to provide an insight to Bahasa Melayu learners and focuses on sentence construction involving time reference. This study used both qualitative and quantitative approach in achieving the objectives of the research. A short text taken form Readers’ Digest article entitled ‘Rebirth of the Feral Child’ was chosen as a tool to examine the various types of tenses available in English. We found that Simple Past Tense, Past Continuous Tense, Past Perfect Tense and Present Perfect Tense caused problems when English sentences were translated to Malay sentences. This study is hoped to provide a brief and clear explanation to the foreign learners of Malay and Malay learners of English on how the sentence construction in both English and Malay are different to each other especially those that are related to the time reference.
Battery Management System for Microgrids

A novel approach of project is to model and control of a battery management system used in microgrid. The system composed of photovoltaic array and battery. The photovoltaic array normally uses a maximum power point tracking (MPPT) technique to continuously deliver the highest power to the load, when there are irradiation and temperature. The disadvantage of photovoltaic energy is that photovoltaic output power depends upon weather condition and cell temperature making it an uncontrollable source. To make the system controllable, the battery is considered. This battery compensate the load variations when solar power is damping in nature. System has two operation modes, the unit-power control (UPC) mode and the feeder-flow control (FFC) mode, applied to hybrid system. When load is light, the UPC mode is selected. In UPC mode variation in load demands are compensated by the main grid because the hybrid source output is regulated to reference power. In FFC mode feeder flow is regulated to a constant power, the extra load demand is picked up by hybrid sources and hence feeder reference power must be known. The system can maximize the generated power when load is heavy and minimizes the load shedding area. The proposed operating strategies with flexible operation mode change always operates the photovoltaic array at maximum output power and battery in its high efficiency performance band, thus improving the performance of system operation, enhance system stability, decreasing the number of operating mode changes in the MATLAB Simulink environment.
Influence of electrolytes on the release of tramadol hydrochloride from controlled release matrix tablets

October-December 2015 712 JCPS Volume 8 Issue 4 Influence of electrolytes on the release of tramadol hydrochloride from controlled release matrix tablets Baby Sravani Guduru, Indira Kilari and Ramana Gangireddy Dept.Pharmaceutics, KVSR Siddhartha College of Pharmacy, Vijayawada-520010, Andhra Pradesh, India. *Corresponding author: E Mail: sravani.guduru222@gmail.com ABSTRACT The main aim of the present investigation was to study the effect of electrolytes dried aluminum hydroxide and calcium carbonate on the release of Tramadol hydrochloride (THL) form HPMC K4M controlled release matrix tablets. Totally 9 formulations were prepared with varying concentration of electrolytes. All the formulations fulfilled the pre compression parameters like angle of repose and compressibility index. The blends were compressed in to CR tablets by direct compression method. In-vitro dissolution studies were performed in 1.2N HCl for 2hrs and pH 7.4 phosphate buffer over 12hrs. Among all the formulations, F2 (containing 6.66% w/w of dried aluminum hydroxide) and F6 (6.66% w/w of calcium carbonate) showed the controlled drug release of 94.98% and 94.87% over 12hrs. To ascertain the mechanism of Tramadol Hydrochloride release data was fitted into various release kinetic models. All the formulations results showed prolonged and controlled release and compliance with Higuchi plot which reveals that the drug reveals follows Non-Fickian diffusion mechanism. The FTIR spectral analysis also reveals that there was no interaction between the drug and polymers used.
Shock Wave Therapy and Ultrasound Therapy plus Exercises for Frozen Shoulder Joint Clients

Purpose: The aim of this study is to assess influence of shockwave therapy plus exercise and ultrasound therapy plus exercises on pain severity and range of motion with frozen shoulder joint patients. Patients: twenty patients with frozen shoulder joint patients, Illness time ranging between 2-9 months participated in this study at Palestine Ahliya University. They were randomly chosen from orthopedic surgeon assigned into 2 equal groups. Each group consists of ten patients. Methods: Patients were analyzed pre and post treatment for shoulder pain severity by pain scale (VAS) and range of motion (ROM) of the shoulder joint by using goniometer. Group (A) received shock wave therapy, 2000 impulses per session, an energy flex density of 0.22mJ/mm2 , pulse rate 10/sec and frequency 1-15 Hz plus an exercise program. Group (B) received ultrasound with a frequency of 3MH, and intensity 1w/cm was applied on the affected shoulder at the site of pain using ultrasound gel for 5 minute plus the same exercise program. The two groups received treatment 3 times per week for 4 weeks. Results: (SWT) plus exercises and (UST) plus exercise were effective in decreasing shoulder joint pain and increase ROM. Moreover, (SWT) group was the most influential in decreasing pain and exaggerating range of motion of the shoulder joint. Conclusion: (SWT) group and (US) group are beneficial in decreasing pain and increasing range of motion with frozen shoulder joint and should emphasis added to the physical therapy program.
Factors Affecting Adherence to Highly Active Antiretroviral Therapy among Patients Attending Public Healthcare Facility

The research focused on factors associated with poor adherence to HAART (highly active antiretroviral therapy) among HIV/AIDS. A descriptive cross sectional study was conducted using a standardized questionnaire and face-to-face exit interviews to collect data. Pill-counts were performed and computed adherence rate of ≥ 95% was considered acceptable. Data were analyzed using SPSS 21.0. Univariate factors associated with poor dherence to HAART were assessed with ANOVA (analysis of variance) and logistic regression model excluded confounders determining independent predictors of poor adherence. A P ≤ 0.05 was statistical significant. Of 102 HIV-infected on HAART for 24.68 ± 20.5 months, 83.3% were females and 16.7% males. The mean age (± SD) was 35.09 ± 9.3 years. Univariate factors associated with poor adherence to HAART were: CD4 count > 350 cells/mm (χ2 = 46; P = 0.05), age > 35 years (χ2 = 28.75; P = 0.011), primary educational background (χ2 = 9.18; P = 0.027), HAART regimen 1A-TDF (χ2 = 14.37; P = 0.003), and > 4 combined tablets (χ2 = 11.87; P = 0.001). There was a linear correlation between age and primary educational background (r = 0.538; P < 0.001). After adjusting for univariate confounders, primary educational background (P = 0.020) and > 4 combined tablets (P = 0.026) were identified as independent predictors of poor adherence to HAART. Although there is an increase number of HIV-infected receiving HAART, these findings have shown that many of these will not adhere to their treatment once they improve clinically. This could be due to lack of education and complexity of combined ARVs with other drugs.