Miracle-dz/UniFAR-FTUs huggingface dataset:
The Global Circulation of Seasonal Influenza A (H3N2) Viruses

Antigenic and genetic analysis of the hemagglutinin of ∼13,000 human influenza A (H3N2) viruses from six continents during 2002–2007 revealed that there was continuous circulation in east and Southeast Asia (E-SE Asia) via a region-wide network of temporally overlapping epidemics and that epidemics in the temperate regions were seeded from this network each year. Seed strains generally first reached Oceania, North America, and Europe, and later South America. This evidence suggests that once A (H3N2) viruses leave E-SE Asia, they are unlikely to contribute to long-term viral evolution. If the trends observed during this period are an accurate representation of overall patterns of spread, then the antigenic characteristics of A (H3N2) viruses outside E-SE Asia may be forecast each year based on surveillance within E-SE Asia, with consequent improvements to vaccine strain selection.
Frequency Splitting Analysis of Two-Coil Resonant Wireless Power Transfer

Frequency splitting has been widely observed in resonant wireless power transfer (RWPT). However, there are some misunderstandings concerning this phenomenon in the two-coil RWPT structure. Based on the circuit theory, this letter deduces the expressions of the voltage ratio, the output power, and the efficiency varying with the driving frequency, supplied by a constant ac voltage source. Frequency splitting occurs in the voltage gain and the output power, and the splitting frequency points are deduced. As to the efficiency, no frequency splitting exists, contrary to the current mainstream research. The calculations and the experiments confirm these conclusions.
Infant mortality statistics from the 2009 period linked birth/infant death data set.

OBJECTIVES This report presents 2009 period infant mortality statistics from the linked birth/infant death data set (linked file) by maternal and infant characteristics. The linked file differs from the mortality file, which is based entirely on death certificate data. METHODS Descriptive tabulations of data are presented and interpreted. RESULTS The infant mortality rate in the United States in 2009 was 6.39 infant deaths per 1,000 live births, 3% lower than the rate of 6.61 in 2008. The number of infant deaths was 28,075 in 2008 and 26,408 in 2009, a decline of 1,667 infant deaths. Infant mortality rates ranged from 4.40 per 1,000 live births for Asian or Pacific Islander mothers to 12.40 for non-Hispanic black mothers. Infant mortality was higher for male infants and infants born preterm or at low birthweight. Infant mortality rates were also higher for those infants who were born in multiple deliveries, to mothers who were unmarried, and for those whose mothers were born in the 50 states or the District of Columbia. From 2008 to 2009, the neonatal mortality rate (under age 28 days) declined 3% to 4.18 neonatal deaths per 1,000 live births, while the postneonatal mortality rate (aged 28 days to under 1 year) declined 5% to 2.21. Preterm and low birthweight infants had the highest infant mortality rates and contributed greatly to overall U.S. infant mortality. The three leading causes of infant death--congenital malformations, low birthweight, and sudden infant death syndrome--accounted for 46% of all infant deaths. In 2009, 35.4% of infant deaths were "preterm-related. "
Analysis of blocking matrices for generalized sidelobe cancellers for non-stationary broadband signals

This contribution relates the robust generalized sidelobe canceller (RGSC) with an adaptive blocking matrix (ABM) after Hoshuyama et al. for non-stationary broadband signals with linearly constrained minimum variance (LCMV) beamformers. While alternative approaches only exploit spatial wave field characteristics, it is shown that the ABM introduces dependency on the desired signal power spectral density (PSD) into the array look-direction constraints. The ABM yields better interference suppression than for stationary frequency independent look-direction constraints, since the ABM does not suppress frequencies without desired signal components.
Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study

OBJECTIVE White matter lesions are often seen on MR scans of elderly non-demented and demented people. They are attributed to degenerative changes of small vessels and are implicated in the pathogenesis of cognitive decline and dementia. There is evidence that especially periventricular white matter lesions are related to cognitive decline, whereas subcortical white matter lesions may be related to late onset depression. The frequency distribution of subcortical and periventricular white matter lesions according to age and sex reported. METHODS A total of 1077 subjects aged between 60–90 years were randomly sampled from the general population. All subjects underwent 1.5T MR scanning; white matter lesions were rated separately for the subcortical region and the periventricular region. RESULTS Of all subjects 8% were completely free of subcortical white matter lesions, 20% had no periventricular white matter lesions, and 5% had no white matter lesions in either of these locations. The proportion with white matter lesions increased with age, similarly for men and women. Women tended to have more subcortical white matter lesions than men (total volume 1.45 ml v 1.29 ml; p=0.33), mainly caused by marked differences in the frontal white matter lesion volume (0.89 ml v 0.70 ml; p=0.08). Periventricular white matter lesions were also more frequent among women than men (mean grade 2.5 v 2.3; p=0.07). Also severe degrees of subcortical white matter lesions were more common in women than in men (OR 1.1; 95% confidence interval (95% CI) 0.8–1.5) and periventricular white matter lesions (OR 1.2; 95% CI 0.9–1.7), albeit that none of these findings were statistically significant. CONCLUSIONS The prevalence and the degree of cerebral white matter lesions increased with age. Women tended to have a higher degree of white matter lesions than men. This may underlie the finding of a higher incidence of dementia in women than in men, particularly at later age.
Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 2.

In experimental studies in the dog, total proximal coronary artery occlusions of up to 15 minutes result in reversible injury, meaning that the myocytes survive this insult. The 15 minutes of ischemia, however, induce numerous changes in the myocardium, including certain monuments to the brief episode of ischemia that may persist for days. One of these monuments is stunned myocardium, which represents "prolonged postischemic contractile dysfunction of myocardium salvaged by reperfusion. " The mechanism of stunning involves generation of oxygen radicals as well as alteration in calcium homeostasis and possibly alteration in contractile protein structure. Stunning has been observed in several clinical scenarios, including after percutaneous transluminal coronary angioplasty, unstable angina, stress-induced ischemia, after thrombolysis, and after cardiopulmonary bypass. Oxygen radical scavengers and calcium channel blockers have been shown to enhance function of stunned myocardium in experimental studies, and in a few clinical studies, calcium channel blockers have been shown to ameliorate stunning. Although brief periods of ischemia can contribute to prolonged left ventricular dysfunction and even heart failure, they paradoxically play a cardioprotective role. Episodes of ischemia as short as 5 minutes, followed by reperfusion, protect the heart from a subsequent longer coronary artery occlusion by markedly reducing the amount of necrosis that results from the test episode of ischemia. This phenomenon, called ischemic preconditioning, has been observed in virtually every species in which it has been studied and is a powerful cardioprotective effect. The mechanism of ischemic preconditioning involves both triggers and mediators and involves complex second messenger pathways that appear to involve such components as adenosine, adenosine receptors, the epsilon isoform of protein kinase C, the ATP-dependent potassium channels, as well as others, including a paradoxical protective role of oxygen radicals. Both an early and a late phase of preconditioning have been described, and the mechanisms underlying their induction are under investigation. That preconditioning may occur in humans is suggested by the observations that repetitive balloon inflations in the coronary artery are associated with progressively less chest pain, ST-segment elevation, lactate production, the protective effects of preinfarction angina, the anginal "warm-up phenomenon," and studies performed on human cardiac biopsies that show metabolic properties suggesting preconditioning. Development of pharmacological agents that stimulate second messenger pathways thought to be involved in preconditioning, but without causing ischemia, could result in novel approaches to treating ischemia. Hence, on one hand, brief episodes of ischemia can have a negative effect on the heart: stunning; and on the other hand, they have a protective effect: preconditioning. The future challenge is how to minimize the stunning phenomenon and maximize the preconditioning phenomenon in clinical practice.
Perception of shape from shading on a cloudy day

The human visual system has a remarkable ability to interpret smooth patterns of light and shade on a surface in terms of 3-D surface geometry. Classical studies of shape{ from{shading have assumed that surface luminance depends on the local surface orientation. This classical shading model holds, for example, on a sunny day. A common situation in which the classical model fails to hold, however, is a di use lighting condition such as on a cloudy day. Here we report on the rst set of psychophysical experiments that explicitly address perception of shape{from{shading under di use lighting. Our main ndings are that depth discrimination under di use lighting is superior to that predicted by a classical sunny day model, and by a model in which depth varies with perceived luminance i.e. dark means deep . We nd that performance is correlated with the latter model, however, under both di use source and point source lighting. The results imply that the visual system uses multiple models when perceiving shape{from{shading.
Parent Instrumentality for Adolescent Eating and Activity.

BACKGROUND Parent-adolescent interactions have health implications for adolescents. Parents can be instrumental to healthy eating by purchasing fruits and vegetables or refraining from purchasing hedonic (low nutrient, high energy-dense) foods. Parents can be instrumental to healthy activity by modeling exercise behavior or discouraging sedentary activities. PURPOSE This research leverages theory on goal pursuit within relationships to investigate whether parents are instrumental to adolescents' eating and activity. METHODS Using a national sample of 1,556 parent-adolescent dyads, we conducted dyadic analyses to examine whether parent instrumentality (both parent-perceived and adolescent-perceived) for healthy behaviors was associated with adolescent engagement in those behaviors. We examined whether the link between parent instrumentality and adolescent BMI was mediated by parent instrumentality. We also explored whether parent instrumentality was associated with parent behaviors and parent BMI. RESULTS Greater adolescent-perceived parent instrumentality was associated with greater fruit and vegetable consumption and physical activity, and lower sedentariness. Parent-perceived parent instrumentality was associated with greater adolescent fruit and vegetable consumption, less hedonic eating, and more activity. Mediation modeling suggests that adolescent BMI is partially attributable to parent instrumentality for activity. Instrumental parents also engage in healthier behaviors, some of which in turn are associated with lower parent BMI. CONCLUSIONS Findings have implications for the promotion of healthy eating and activity patterns among adolescents. Parental instrumentality for behavior may be an important target for interventions to improve adolescent health, and interventions may be most successful in facilitating adolescent behavior change if they target both parent- and adolescent-perceived parent instrumentality.
Developmental enhancers and chromosome topology

Developmental enhancers mediate on/off patterns of gene expression in specific cell types at particular stages during metazoan embryogenesis. They typically integrate multiple signals and regulatory determinants to achieve precise spatiotemporal expression. Such enhancers can map quite far—one megabase or more—from the genes they regulate. How remote enhancers relay regulatory information to their target promoters is one of the central mysteries of genome organization and function. A variety of contrasting mechanisms have been proposed over the years, including enhancer tracking, linking, looping, and mobilization to transcription factories. We argue that extreme versions of these mechanisms cannot account for the transcriptional dynamics and precision seen in living cells, tissues, and embryos. We describe emerging evidence for dynamic three-dimensional hubs that combine different elements of the classical models.
Atrial fibrillation in patients undergoing coronary artery surgery is associated with adverse outcome

Abstract Background: The aim was to determine the association between atrial fibrillation (AF) and outcome in patients undergoing coronary artery bypass grafting (CABG). Methods: All patients undergoing CABG between January 2010 and June 2013 were identified in the Swedish Heart Surgery Registry. Outcomes studied were all-cause mortality, cardiovascular mortality, myocardial infarction, congestive heart failure, ischemic stroke, and recurrent AF. Patients with history of AF prior to surgery (preoperative AF) and patients without history of AF but with AF episodes post-surgery (postoperative AF) were compared to patients with no AF using adjusted Cox regression models. Results: Among 9,107 identified patients, 8.1% (n = 737) had preoperative AF, and 25.1% (n = 2,290) had postoperative AF. Median follow-up was 2.2 years. Compared to no AF, preoperative AF was associated with higher risk of all-cause mortality, adjusted hazard ratio with 95% confidence interval (HR) 1.76 (1.33–2.33); cardiovascular mortality, HR 2.43 (1.68–3.50); and congestive heart failure, HR 2.21 (1.72–2.84). Postoperative AF was associated with risk of all-cause mortality, HR 1.27 (1.01–1.60); cardiovascular mortality, HR 1.52 (1.10–2.11); congestive heart failure, HR 1.47 (1.18–1.83); and recurrent AF, HR 4.38 (2.46–7.78). No significant association was observed between pre- or postoperative AF and risk for myocardial infarction and ischemic stroke. Conclusions: Approximately 1 in 3 patients undergoing CABG had pre- or postoperative AF. Patients with pre- or postoperative AF were at higher risk of all-cause mortality, cardiovascular mortality, and congestive heart failure, but not of myocardial infarction or ischemic stroke. Postoperative AF was associated with higher risk of recurrent AF.
Biomarkers for Early Stages of Johne’s Disease Infection and Immunization in Goats

Background: Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) is the causative agent of Johne’s disease, a chronic enteric infection of ruminants. Infection occurs within the first few months of life but remains subclinical for an average of 2–5 years. Current diagnostics to detect early subclinical infections lack diagnostic sensitivity, which hinders disease control resulting in significant economic losses to the dairy industry worldwide. The pathophysiology of early infection with M. paratuberculosis is still not well understood and represents a key hurdle toward the development of better diagnostics. Methods: The present study employed a large-scale RNA-Sequencing technology to better understand early stages of M. paratuberculosis infection and immunization. Specifically, gene expression profiles of peripheral blood mononuclear cells (PBMCs) from infected or vaccinated goats were compared to controls. Results: When compared to the naïve control goats, we identified a large number of transcripts (N = 226, 1018, 1714) that were differentially expressed in the M. paratuberculosis-infected goats, goats vaccinated with live attenuated or inactivated vaccines. There were also 1133 differentially expressed (DE) transcripts between vaccinated goats and infected ones. Bioinformatics evaluation of the DE genes indicated the regulation of a large number of genes with immunity and inflammatory functions including IL-18BP, IFN-γ, IL-17A, NOS2, LIPG, and IL-22. Interestingly, a large number of goat genes (N = 667) were regulated whether live or inactivated vaccine were used. Some of the regulated genes (e.g., IL-17A, IFN-γ) continued its unique transcriptional profile up to 12 months post-challenge. Conclusion: Overall, transcriptome analysis of infected and/or immunized goats identified potential targets for developing early diagnostics for Johne’s disease and a potential approach to differentiate infected from vaccinated animals. A similar approach could be used to analyze later stages of Johne’s disease or other chronic infections.
Sweet fish: Fish models for the study of hyperglycemia and diabetes

Fish are good for your health in more ways than you may expect. For one, eating fish is a common dietary recommendation for a healthy diet. However, fish have much more to provide than omega‐3 fatty acids to your circulatory system. Some fish species now serve as important and innovative model systems for diabetes research, providing novel and unique advantages compared with classical research models. Not surprisingly, the largest share of diabetes research in fish occurs in the laboratory workhorse among fish, the zebrafish (Danio rerio). Established as a genetic model system to study development, these small cyprinid fish have eventually conquered almost every scientific discipline and, over the past decade, have emerged as an important model system for metabolic diseases, including diabetes mellitus. In this review we highlight the practicability of using zebrafish to study diabetes and hyperglycemia, and summarize some of the recent research and breakthroughs made using this model. Equally exciting is the appearance of another emerging discipline, one that is taking advantage of evolution by studying cases of naturally occurring insulin resistance in fish species. We briefly discuss two such models in this review, namely the rainbow trout (Oncorhynchus mykiss) and the cavefish (Astyanax mexicanus).
Maternal Nutrition and Body Composition During Breastfeeding: Association with Human Milk Composition

The composition of human milk is dynamic and can vary according to many maternal factors, such as diet and nutritional status. This study investigated the association of maternal nutrition and body composition with human milk composition. All measurements and analyses were done at three time points: during the first (n = 40), third (n = 22), and sixth (n = 15) month of lactation. Human milk was analyzed using the Miris human milk analyzer (HMA), body composition was measured with bioelectrical bioimpedance (BIA) using a Maltron BioScan 920-II, and the assessment of women’s nutrition was based on a three-day dietary record. The correlation coefficient (Pearson’s r) did not show a significant statistical relationship between human milk composition and nutrients in women’s diet at three time points. For women in the third month postpartum, we observed moderate to strong significant correlations (r ranged from 0.47 to 0.64) between total protein content in milk and the majority of body composition measures as follows: positive correlations: % fat mass (r = 0.60; p = 0.003), fat-free mass expressed in kg (r = 0.63; p = 0.001), and muscle mass (r = 0.47; p = 0.027); and negative correlation: % total body water (r = −0.60; p = 0.003). The variance in milk fat content was related to the body mass index (BMI), with a significant positive correlation in the first month postpartum (r = 0.33; p = 0.048). These findings suggest that it is not diet, but rather the maternal body composition that may be associated with the nutritional value of human milk.
Technical Note - A Robust Perspective on Transaction Costs in Portfolio Optimization

We prove that the portfolio problem with transaction costs is equivalent to three different problems designed to alleviate the impact of estimation error: a robust portfolio optimization problem, a regularized regression problem, and a Bayesian portfolio problem. Motivated by these results, we propose a data-driven approach to portfolio optimization that tackles transaction costs and estimation error simultaneously by treating the transaction costs as a regularization term to be calibrated. Our empirical results demonstrate that the data-driven portfolios perform favorably because they strike an optimal trade-off between rebalancing the portfolio to capture the information in recent historical return data and avoiding the large transaction costs and impact of estimation error associated with excessive trading. The online companion is available at https://doi.org/10.1287/opre.2017. 1699.
Observational fear behavior in rodents as a model for empathy

Empathy enables social mammals to recognize and share emotion with others and is well‐documented in non‐human primates. During the past few years, systematic observations have showed that a primal form of empathy also exists in rodents, indicating that empathy has an evolutionary continuity. Now, using rodents exhibiting emotional empathy, the molecular and cellular study of empathy in animals has begun in earnest. In this article, we will review recent reports that indicate that rodents can share states of fear with others, and will try to highlight new understandings of the neural circuitry, biochemistry and genetics of empathic fear. We hope that the use of rodent models will enhance understanding of the mechanisms of human empathy and provide insights into how to treat social deficits in neuropsychiatric disorders characterized by empathy impairment.