Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of four recovery methods on repeated maximal rock climbing performance.

PURPOSE Considering the development of rock climbing as a competitive sport, we aimed at investigating the influence of four recovery methods on subsequent maximal climbing performance. METHODS In a randomly assigned crossover design, 13 female well-trained climbers (27.1 +/- 8.9 yr) came to the climbing center on four occasions separated by 1 wk. On each occasion, they had to perform two climbing tests (C1 and C2) until volitional exhaustion on a prepracticed route (overhanging wall, level 6b). These two tests were separated by 20 min of recovery. Four recovery methods were used in randomized order: passive recovery, active recovery (cycle ergometer, 30-40 W), electromyostimulation on the forearm muscles (bisymmetric TENS current), or cold water immersion of the forearms and arms (three periods of 5 min at 15 +/- 1 degrees C). Climbing tests' performance was reflected by the number of arm movements and climb duration. RESULTS Using active recovery and cold water immersion, performance at C2 was maintained in comparison with C1, whereas C2 performance was impaired compared with C1 (P< 0.01) using electromyostimulation and passive recovery (recovery method-by-climb interaction, P < 0.05). Blood lactate decreased during recovery, with the greatest decrease occurring during active recovery (time-by-recovery method interaction, P < 0.001). Arms and forearms' skin temperatures were lower throughout the cold water immersion compared with the other three methods (P < 0.001). CONCLUSION Active recovery and cold water immersion are two means of preserving performance when repeating acute exhausting climbing trails in female climbers. These positive effects are accompanied by a greater lactate removal and a decrease in subcutaneous tissues temperatures, respectively.
An ASIC implementation of low area AES encryption core for wireless networks

This paper presents an efficient ASIC implementation of the low area 8-bit AES encryption core using an optimized SBox for wireless networks. The proposed AES core supports 128- bit key length and 128-bit data blocks. The implementation results in a 90nm CMOS standard library show that the proposed AES encryption core has the maximum clock frequency of 452.5 MHz and higher resource usage efficiency compared with other designs.
An Induced Proximity Model for NF-κB Activation in the Nod1/RICK and RIP Signaling Pathways

Abstract Nod1 is an Apaf-1-like molecule composed of a caspase-recruitment domain (CARD), nucleotide-binding domain, and leucine-rich repeats that associates with the CARD-containing kinase RICK and activates nuclear factor κB (NF-κB). We show that self-association of Nod1 mediates proximity of RICK and the interaction of RICK with the γ subunit of the IκB kinase (IKKγ). Similarly, the RICK-related kinase RIP associated via its intermediate region with IKKγ. A mutant form of IKKγ deficient in binding to IKKα and IKKβ inhibited NF-κB activation induced by RICK or RIP. Enforced oligomerization of RICK or RIP as well as of IKKγ, IKKα, or IKKβ was sufficient for induction of NF-κB activation. Thus, the proximity of RICK, RIP, and IKK complexes may play an important role for NF-κB activation during Nod1 oligomerization or trimerization of the tumor necrosis factor α receptor.
Comparison of the effects of carvedilol and nebivolol on diastolic functions of the left ventricle in patients with non-ischemic heart failure.

BACKGROUND We investigated whether carvediolol or nebiovolol with vasodilator properties will produce different effects on diastolic function of the left ventricle (LV) in heart failure (HF) with low ejection fraction (EF). METHODS Sixty-one non-ischemic HF patients with EF ≤40% randomly received carvedilol (n = 31, 16 male) or nebivolol (n = 30, 19 male). Clinical and echocardiographic evaluations were performed at baseline, 3 and 6 months after therapy. Mitral inflow velocities (E and A waves), deceleration time of E wave (DT), isovolumetric relaxation time (IVRT), mitral annular velocities (Ea and Aa waves) were evaluated. Mitral E/A and E/Ea ratios were calculated. RESULTS In carvediolol and nebivolol groups, mitral E/A ratio (from 1.08 ± 0.31 to 0.87 ± 0.30 vs. from 0.98 ± 0.20 to 0.80 ± 0.20, p = 0.30) and IVRT (from 108 ± 13 to 94 ± 10 ms vs. from 107 ± 22 to 92 ± 10 ms, p = 0.25) similarly decreased while DT prolonged (from 184 ± 40 to 218 ± 42 ms vs. from 193 ± 37 to 222 ± 36 ms, p = 0.71). Also, E/Ea ratio significantly decreased in each group (p = 0.01), but it was lower in nebivolol group than carvedilol group at 6 months (10.2 ± 2 vs. 11.8 ± 2, p = 0.01). Carvediolol and nebivolol reduced similarly N-terminal pro-B type natriuretic peptide level (from 666 to 137 vs. 661 to 123 pg/dL, p = 0.41, respectively) and improved functional capacity (p > 0.05). CONCLUSIONS At 6 month follow-up, carvedilol and nebivolol appear to similarly improve LV diastolic functions in non-ischemic HF patients.
Asthma mortality in U.S. Hispanics of Mexican, Puerto Rican, and Cuban heritage, 1990-1995.

We used national vital statistics data for 1990 through 1995 to examine both national and regional age-adjusted asthma mortality rates for U.S. Hispanics of Mexican, Cuban, and Puerto Rican heritage, as well as for non-Hispanic whites and non-Hispanic blacks. Nationally, Puerto Ricans had an age-adjusted annual asthma mortality rate of 40.9 per million, followed by Cuban-Americans (15. 8 per million) and Mexican-Americans (9.2 per million). In comparison, non-Hispanic whites had an age-adjusted annual asthma mortality rate of 14.7 per million and non-Hispanic blacks had a rate of 38.1 per million. Age-adjusted asthma mortality for Puerto Ricans was highest in the Northeast (47.8 per million); this region accounted for 81% of all asthma deaths among Puerto Ricans in the United States. In the U.S., Puerto Ricans had the highest asthma mortality rates among Hispanics, followed by Cuban-Americans and Mexican-Americans. In addition, among Hispanic national groups, mortality rates were consistently higher in the Northeast than the Midwest, South, or West regions. These results further support that Hispanics do not represent a uniform, discrete group in terms of health outcomes, and that further public health research and interventions should take Hispanic national origin into account.
A motion tracking method by combining the IMU and camera in mobile devices

In order to track the localizations of mobile devices in an unknown environment, this paper presents an architecture combining a monocular camera and an inertial measurement unit (IMU) in ubiquitous mobile devices. The IMU module provides acceleration and angular velocity with high-frequency, but the IMU-based motion tracking is more inclined to collapse due to the drift integration. While the vision-based motion tracking can provide higher accuracy, but it cannot work in the environment with weak texture or dynamic scenes. Based on the fusion of the IMU and monocular camera, this paper proposed a loosely couple method in the error-state Extended Kalman Filter framework. With the combination of the advantages the monocular camera and IMU, the proposed method can achieve real-time ego-motion estimation in resource-constrained mobile devices. Finally, the validity of the proposed motion tracking method is evaluated by experiments.
From spots to beads—PTM‐peptide bead arrays for the characterization of anti‐histone antibodies

Antibodies that recognize PTMs of histones play a central role in epigenetic proteomic research. Modification‐specific antibodies are employed in chromatin immunoprecipitation, for Western blotting and during the immunoprecipitation steps for MS‐based global proteomic analyses. Knowledge about the antibodies’ off‐target binding is essential for the interpretation of experimental data. To address this challenge we developed a fast and cost efficient system for generating peptide bead arrays. We employed this method to establish a bead‐based peptide array containing 384 peptides displaying phosphorylated, acetylated, methylated, and citrullinated N‐terminal regions of histones H2A, H2B, H3 and H4 and controls. We profiled the binding of 40 PTM‐specific antibodies important for epigenetic proteomic research.
Markov Chain Monte Carlo Model Composition Search Strategy for Quantitative Trait Loci in a Bayesian Hierarchical Model

— Quantitative trait loci (QTL) experiments have yielded important biological and biochemical information necessary for understanding the relationship between genetic markers and quantitative traits. For many years, most QTL algorithms only allowed one observation per genotype. Recently, there has been an increasing demand for QTL algorithms that can accommodate more than one observation per genotypic distribution. The Bayesian hierarchical model is very flexible and can easily incorporate this information into the model. Herein a methodology is presented that uses a Bayesian hierarchical model to capture the complexity of the data. Furthermore, the Markov chain Monte Carlo model composition (MC 3 ) algorithm is used to search and identify important markers. An extensive simulation study illustrates that the method captures the true QTL, even under nonnormal noise and up to 6 QTL.
A wireless MIMO CPM system with incoherent demodulation

A multiple-input multiple-output (MIMO) wireless transmission system with continuous phase modulation (CPM) is considered. A novel MIMO CPM receiver with incoherent modulation is presented. The incoherent demodulation of CPM allows an uncomplicated handling of a frequency offset compared to coherent approaches requiring exact knowledge of the carrier frequency. Blind signal separation (BSS) is applied in the proposed MIMO CPM receiver to separate the signals without any knowledge of the MIMO channel. The BSS permits the demodulation of each separated signal by an incoherent CPM demodulator. For bandwidth efficient transmission partial response CPM and non-binary modulation is applied. The applicability of the proposed system is verified by simulation results.
The Gene Network Underlying Hypodontia

Mammalian tooth development is a precise and complicated procedure. Several signaling pathways, such as nuclear factor (NF)–κB and WNT, are key regulators of tooth development. Any disturbance of these signaling pathways can potentially affect or block normal tooth development, and presently, there are more than 150 syndromes and 80 genes known to be related to tooth agenesis. Clarifying the interaction and crosstalk among these genes will provide important information regarding the mechanisms underlying missing teeth. In the current review, we summarize recently published findings on genes related to isolated and syndromic tooth agenesis; most of these genes function as positive regulators of cell proliferation or negative regulators of cell differentiation and apoptosis. Furthermore, we explore the corresponding networks involving these genes in addition to their implications for the clinical management of tooth agenesis. We conclude that this requires further study to improve patients’ quality of life in the future.
Optimal power allocation for OFDM cognitive system based on dual decomposition method

In this paper, the problem of optimal power allocation for OFDM based cognitive radio (CR) system is studied. The maximum transmit rate of cognitive user (CU) is expressed as a convex problem with both total transmit power constraint and interference power constraint. Using dual decomposition method, the linear coupled constraints are decoupled one by one, and the original optimization problem is transferred to several sub-problems which are easy to be solved. A two level dual variable iterative (TLDVI) algorithm is proposed to obtain the final optimal power allocation with lower complexity. Simulation results show that the proposed algorithm convergence fast and can achieve the same maximum transmit rate performance of CU as the standard interior point algorithm.
Estrogen Rapidly Induces c-jun Immunoreactivity in Rat Striatum

Estrogen has been reported to exert rapid effects on the function of neurons located in various brain regions, including those where classical estrogen receptors are not abundant, such as the striatum. The mechanism underlying these actions is not well understood, but does not appear to involve classical estrogen receptor-mediated genomic mechanisms. Estrogen has also been shown to regulate expression of immediate-early gene products in many tissues. In the present study, immunohistochemical methods were used to determine whether estrogen modulates the appearance of c-jun immunoreactivity (IR) in the striatum of rats. Administration of estradiol (100 micrograms/rat) to ovariectomized rats for 15 min induced a rapid and transient increase in c-jun-IR in the dorsomedial striatum and the core region of the nucleus accumbens. These data suggest that c-jun may serve as one of the rapidly responding mediators of estrogen action in the striatum and nucleus accumbens.
Neutral serine proteases of neutrophils

Neutrophil serine proteases (NSPs) exercise tissue‐degrading and microbial‐killing effects. The spectrum of NSP‐mediated functions grows continuously, not least because of methodological progress. Sensitive and specific FRET substrates were developed to study the proteolytic activity of each NSP member. Advanced biochemical methods are beginning to characterize common and specific NSP substrates. The resulting novel information indicates that NSPs contribute not only to genuine inflammatory neutrophil functions but also to autoimmunity, metabolic conditions, and cancer. Tight regulatory mechanisms control the proteolytic potential of NSPs. However, not all NSP functions depend on their enzymatic activity. Proteinase‐3 (PR3) is somewhat unique among the NSPs for PR3 functions as an autoantigen. Patients with small‐vessel vasculitis develop autoantibodies to PR3 that bind their target antigens on the neutrophil surface and trigger neutrophil activation. These activated cells subsequently contribute to vascular necrosis with life‐threatening multiorgan failure. This article discusses various aspects of NSP biology and highlights translational aspects with strong clinical implications.
Photolithography-free interdigitated back-contacted silicon heterojunction solar cells with efficiency >21%

We report on the development of interdigitated back-contacted silicon heterojunction solar cells with conversion efficiencies well above 21%. Doped hydrogenated amorphous silicon layers, needed for electron and hole collection, are patterned via in-situ shadow masking whereas transparent conductive oxide and metal layers, of the back electrodes, are defined via hot melt inkjet printing of an etch resist and subsequent wet etching. Our technology is therefore photolithography-free and avoids any high-temperature step. The best fabricated solar cell presents a high short-circuit current density of 39.9 mA/cm2, an open-circuit voltage of 724 mV and a fill factor of 74.5% resulting in a conversion efficiency of 21.5%, with a strong upside potential. We report also on a silver-free IBC-SHJ solar cell with conversion efficiency >20%.
On Modern Technical Approaches of Three- Dimensional High-Dose Lattice Radiotherapy (LRT)

Purpose: Two-dimensional (2D) high-dose GRID radiotherapy has shown effective tumor control in the clinical setting, and radiobiological data suggest potent bystander/abscopal effects with this technique. We present a new technical concept using modern radiation therapy instrumentation to advance traditional GRID treatment to modern three-dimensional (3D) highdose LATTICE radiotherapy (LRT).
Metody ścisłe w literaturoznawstwie i pułapki pozornego obiektywizmu – przykład stylometrii

Maciej Eder pedagogical university of cracow Scientific methods in literary studies and the traps of apparent objectivism – the case of stylometry The author discusses several crucial issues related to the use of scientific methods in literary studies, especially the problem of unstable (unreliable) results. With the case study of 28 Polish novels certain limitations of the so-called “cluster analysis” have been presented. In the following part of the article, the author presents the method of calculating textual similarities which is free of such limitations. In order to visualize the results the tools of network analysis have been applied. Even the most advanced techniques of clustering texts are not able to provide absolute objectivism of an experiment.
Micromotility meter: an instrument designed to evaluate the action of drugs on motility of larval and adult nematodes

SUMMARY An instrument for measuring the motility of larval and adult nematodes is described along with an analysis of its use as a tool to analyse drug action on these parasites. Motility was detected from larval parasites of Nippostrongylus brasiliensis and Ascaris suum in the absence and presence of various anti-nematodal drugs. These agents produced, within 48 h, a significant decrease in larval parasite motility. The instrument was also capable of detecting the motility of Caenorhabditis elegans, adult female Brugia pahangi and their response to anti-nematodal drugs. The design of the instrument allows us to accurately measure motility in a single sample within 60 sec.
Model-free active fault-tolerant cooperative control in an offshore wind farm

With respect to the important issue of reliability and availability in wind farms, this paper deals with the development of an integrated fault diagnosis and fault-tolerant control scheme in a cooperative framework at wind farm level. The paper presents a novel integrated fault detection and diagnosis (FDD) and fault-tolerant control (FTC) approach oriented to the design and development of an active fault-tolerant cooperative control (FTCC) scheme for an offshore wind farm against the decreased power generation caused by turbine blade erosion and debris build-up on the blades over time. The scheme employs a model-free FDD system to provide accurate and timely diagnosis information to be used in an appropriate automatic signal correction algorithm for accommodation of faults in the farm. Different simulations on a high-fidelity offshore wind farm benchmark model demonstrate the effectiveness and performance of the proposed scheme in the presence of wind turbulences, measurement noises and realistic fault scenarios.
Adaptive Routing Algorithm for Joint Cloud Video Delivery

As the Internet keeps growing, online video has become a great part of the current Internet data traffic, which will take over 80% of Internet traffic according to Cisco's report. Also, new and more heavyweight applications keep developing to fulfill people's growing requirements, like 4k resolution and visual reality videos. However, one single service provider, like a Content Delivery Network (CDN), can not meet the performance requirements completely. To employ the potential of Joint Cloud, this paper designs and implements a new request routing algorithm that can make video delivery utilize multiple clouds and servers. On the premise of guaranteeing the quality of video playing, this algorithm minimizes the cost of service resources based on different infrastructures' service quality, cost, and cover areas. Based on this algorithm, we implement a practical video delivery system using light-weight, flash-based terminals. And this system provides live video and video-on-demand delivery service for China Future Networks Industry Summit 2014 on June 4th. The actual user data was gathered and analyzed to verify the effectiveness of this algorithm. 90.2% of the total VOD requests were completed smoothly without pause, and the video traffic was optimized by the algorithm.
Transthoracic Ventricular Defibrillation with Square‐wave Stimuli: One‐Half Cycle, One Cycle, and Multicycle Waveforms

A very high powered amplifier for experimental transthoracic ventricular defibrillation has been described. The effectiveness of both one-half-cycle unidirectional and one-cycle bidirectional square waves in terminating ventricular fibrillation first increases, then reaches a maximum and finally decreases as the duration of the shock is increased. With 10- and 20-ampere unidirectional shocks and 10-ampere bidirectional shocks, a maximal effectiveness of substantially 100% was found under the chosen experimental conditions. Five-ampere unidirectional and bidirectional shocks yielded maximal effectiveness of 70%. The effectiveness of a 128-millisecond, 5-ampere, multicycle square-wave shock is a strong function of frequency and has a maximal value of approximately 70%.
Devenirs langagier et scolaire d'enfants cérébro-lésés vasculaire et traumatique avant 18 mois

L’etude recherche les sequelles langagieres et scolaires a long terme d’enfants ayant subi un AVC avant l’âge de 18 mois, a environ 6 ans de l’atteinte ; elle recherche aussi a tres long terme ces sequelles pour des enfants TC avant l'âge de 18 mois, a environ 11 ans de l'atteinte. Elle compare ensuite les caracteristiques langagieres et scolaires de chacun de ces deux groupes, a long terme. Pour cela, les resultats d’un bilan de langage oral passe en 2011 par un groupe de 17 enfants TC et les informations concernant leur scolarite et leurs suivis reeducatifs ont ete releves. Les familles ont ensuite ete contactees par telephone pour reactualiser ces informations, au moyen d’un questionnaire systematise. Puis, 3 enfants victimes d’un AVC ont realise un bilan de langage oral. Il ressort de cette recherche qu’a long terme, les sequelles langagieres perdurent suite a un AVC hemorragique et severe uniquement. Les devenirs langagier et scolaire sont comparables a long terme selon que la lesion est d'origine vasculaire ou traumatique. Enfin, les sequelles langagieres suite a un TC persistent a tres long terme. Ces resultats confirment, qu’a long et tres long terme, une lesion cerebrale acquise avant l’âge de 18 mois est responsable de sequelles langagieres et scolaires.
Absolute Stabilization of Multimass Resonant System by Phase-Lead Compensator Based on Disturbance Observer

Vibration suppression and attainment of robustness in motion control systems is a big problem in industry applications. To address this issue, several control methods to suppress the vibration have been developed. However, in the conventional vibration control systems, much of the research has not considered the higher order of resonant frequencies. This paper proposes a novel vibration control of a multimass resonant system based on the phase-lead compensator. It also clarifies the influence of the parameter variation of a disturbance observer on acceleration control system. The effect of phase-lead compensation on the acceleration reference is attained by setting a higher nominal inertia value than the actual one. The phase-lead compensator can stabilize all resonant poles of the multimass resonant system. Since the proposed phase-lead compensation system is based on the disturbance observer technique, it can realize suppression of vibration and robustness in motion systems. The experimental results show viability of the proposed method.