Miracle-dz/UniFAR-FTUs huggingface dataset:
Predicate-based caching in mobile clients for con tinuous partial match queries

This paper proposes a cache management scheme for continuous partial match queries in mobile computing systems. Conventional cache management methods for mobile clients are record ID-based ones. However, since the partial match query is a content-based retrieval, the conventional record ID-based approach cannot properly manage the cache consistency. We show the pr edicate- based approach is an effective cache management in mobile environments.
Incorporation of substrate carbon from [U-14C]acetate by the sheep conceptus recovered from the uterus on days 13 to 19 of pregnancy.

Of the substrate carbon incorporated from 1.12 mM [U-14C]acetate as sole energy substrate during a 2.5-h incubation, a large proportion was isolated in the acid-soluble fraction. Although there was no significant change over time in the rate of entry into this pool for embryos, the rate of accumulation by the trophoblast and yolk sac increased as development progressed. At Days 13 and 15 of pregnancy, incorporation of acetate into the acid-insoluble fraction of embryos accounted for almost half the total label accumulated. The rate of this incorporation fell rapidly over time and by Day 19 less than 30% of carbon accumulated was in this fraction. By contrast, the rate of incorporation into this fraction by trophoblastic tissue was low at Day 13 but rose dramatically as development progressed. Incorporation by the yolk sac into acid-insoluble components also rose with time. At the early stages of pregnancy studied, lipid synthesis accounted for the majority of acetate carbon accumulated by the conceptus in the acid-insoluble pool. At later stages of development, incorporation into lipids constituted a minor pool of acetate carbon. Some acetate carbon was found in the glycogen fraction of the conceptus. The rate of incorporation into the acid-soluble glycogen fraction by embryos was constant throughout the period studied. By contrast, trophoblast increased its rate of incorporation markedly into both acid-soluble and acid-insoluble glycogen pools as did the yolk sac from Day 17. (ABSTRACT TRUNCATED AT 250 WORDS)
A comparative perspective on the evolution of Romance clausal structure

This article presents a comparative analysis of the diachronic evolution of Romance clausal structure from Classical Latin through to the late medieval period, with particular reference to the Verb Second (V2) property. In the medieval period three distinct diachronic stages can be identified as regards V2: a C-VSO stage attested in Old Sardinian, a ‘relaxed’ V2 stage across Early Medieval Romance and maintained into 13th and 14th century Occitan and Sicilian, and a ‘strict’ V2 stage attested in 13th and 14th century French, Spanish and Venetian. The C-VSO grammar found in Old Sardinian is a retention of the syntactic system attested in late Latin textual records, itself an innovation on an ‘incipient V2’ stage found in Classical Latin, where V-to-C movement and XP-fronting receive a pragmatically or syntactically marked interpretation.
Role of metallothionein in human placenta and rats exposed to cadmium.

A strong positive relationship between zinc and copper and metallothionein (MT) in placentas has been found, but a negative one between cadmium and MT. In rats given cadmium i.p. as the chloride, liver cadmium is lower and kidney cadmium higher than in cadmium-treated non-pregnant rats, suggesting that pregnancy enhances mobilization of cadmium from liver to kidney. The cadmium concentration of digested whole fetuses is not significantly increased in offspring of dams given cadmium i.p. as the chloride or CdMT, but the placental levels of cadmium and MT are increased. The placenta therefore acts as a barrier to maternal-fetal cadmium transfer. The way in which cadmium is retained in the placenta but zinc and copper are transferred to the fetus is not understood, since all are bound to MT. Focal renal tubular necrosis and placental necrosis occur at the same level of cadmium exposure, suggesting a similar threshold to cadmium toxicity for the two organs.
Searching for a relationship between manganese and welding and Parkinson’s disease

Research into the causes of Parkinson disease (PD) has accelerated recently with the discovery of novel gene mutations. The majority of PD cases, however, remain idiopathic and in those cases environmental causes should be considered. Several recent reports have focused on welding and manganese toxicity as potential risk factors for parkinsonism and some have even proposed that welding is a risk factor for PD. The controversy has stimulated this review, the primary aim of which is to critically and objectively examine the evidence or lack of evidence for a relationship among welding, manganese, parkinsonism, and PD.
Substrate Integrated Waveguide (SIW) cavity backed slot antenna for polarization diversity application

In this paper, a design of Substrate Integrated Waveguide (SIW) cavity backed slot antenna for polarization diversity application is presented. The proposed design uses a pair of slots placed at right angle with respect to each other at the top metallic plate of the cavity to generate two linear orthogonally polarized radiation pattern at same frequency to implement polarization diversity technique. The antenna interchanges between two separate feed line to excite either of the two orthogonal modes TE120 and TE210 respectively at same frequency and as a result, the proposed antenna exhibits a radiation pattern switching between Vertical (VP) and Horizontal Polarization (HP) at 9.98 GHz. The simulated result of the proposed design shows an isolation better than 20 dB between two input port and a gain of 4.2 dBi at broadside direction.
Electromechanical actuators WEB-lab

Faculty of Mechatronics (FM TnUAD), as one of EDIPE (Leonardo da Vinci) project partners, has built a laboratory of electromechanical actuators, controlled and measured by available Web services. The preliminary results have been presented at important world-wide conference proceedings or journals. The recent state in electromechanical actuators Web-lab will be presented at paper. The used control technology, as well as the measuring equipment and technologies, will be described and discussed. Also the very first experience with designed technology will pre presented with special attention paid to viewpoint of end-user and laboratory staff. Also the basic ideas of booking systems, developed by University of Maribor, and its connection to laboratories in Trencin will be presented.
Comparative analysis of the mycobiota and mycotoxins contaminating corn trench silos and silo bags.

BACKGROUND Silage is one of the most important feed sources for bovines. Mycotoxin contamination of feedstuffs is a worldwide concern. The aim of this study was to compare mycobiota and levels of aflatoxin B₁ (AFB₁), fumonisin B₁ (FB₁), deoxynivalenol (DON), zearalenone (ZEA) and patulin (PAT) in corn trench silos and silo bags. RESULTS Dry matter was higher in trench silos. Counts varied from not detected to 10⁸ CFU g⁻¹ in both trench silos and silo bags. Isolation frequencies of Aspergillus spp. and Fusarium spp. were higher in trench silos, whereas Penicillium spp. was higher in silo bags. Silo bags showed less diversity than trench silos. Strains isolated produced AFB₁, FB₁ and PAT. In trench silos, AFB₁ was the only mycotoxin detected (1-160 µg kg⁻¹). In silo bags AFB₁ levels varied from 5.8 to 47.4 µg kg⁻¹. DON was detected in two silo bag samples. CONCLUSION When handling is adequate the reduction of mould and mycotoxin contamination in silo bags is considerable. This study will enable estimation of the mycotoxicological risk of different ensiling practices and determination of the most adequate method to minimize economic losses and reduce hazard to animal and human health.
The Effects of Menopause and Hormone Replacement Therapy on Quality and Quantity of Tear, Intraocular Pressure and Ocular Blood Flow

Objective: To evaluate the effects of menopause and hormone replacement therapy (HRT) on the quality and amount of tear, intraocular pressure (IOP) and retrobulbar blood flow velocities. Patients and Methods: Twenty women aged between 40 and 50 years, free of ocular and systemic diseases and planning to receive HRT were recruited as the study group. Twenty-four healthy, age-matched but still menstruating women were enrolled as controls. On the first day of study basal and reflex Schirmer test, tear break-up time and IOP measurements (at 08.00, 12.00 and 16.00 h) were performed for all groups. On the second day of the study, the peak systolic velocity (PSV), end diastolic velocity (EDV) and resistivity index (RI) of the ophthalmic (OA), central retinal (CRA), nasal (NSPCA) and temporal short posterior ciliary (TSPCA) arteries were determined by color Doppler imaging. The menopausal group received HRT for 2 months, when all measurements were repeated for the 15 women who had received HRT on a daily basis. Results: The quality and amount of tear decreased (p < 0.01), IOP (p < 0.01) and RI of the CRA, TPCA and NPCA (p < 0.05) increased in postmenopausal women compared with the control group. After 2 months of HRT, the quality and amount of tear had increased (p < 0.001) and the IOP had decreased (p < 0.001). The PSV of the CRA and TSPCA had decreased (p < 0.05), as had the RI in the CRA (p < 0.001), NSPCA and TSPCA (p < 0.05). Conclusion: We conclude that age-induced changes on quality and amount of tear, IOP and retrobulbar blood flow are intensified by the menopause and that it may be possible to decrease the menopausal effects on these parameters by HRT.
Simple model for linear and nonlinear mixing at unstable fluid interfaces with variable acceleration

A simple model is described for predicting the time evolution of the half-width $h$ of a mixing layer between two initially separated immiscible fluids of different density subjected to an arbitrary time-dependent variable acceleration history $a(t). $ The model is based on a heuristic expression for the kinetic energy per unit area of the mixing layer. This expression is based on that for the kinetic energy of a linearly perturbed interface, but with a dynamically renormalized wavelength which becomes proportional to $h$ in the nonlinear regime. An equation of motion for $h$ is then derived from Lagrange's equations. This model reproduces the known linear growth rates of the Rayleigh-Taylor (RT) and Richtmyer-Meshkov (RM) instabilities, as well as the nonlinear RT growth law $h=\ensuremath{\alpha}{\mathrm{Aat}}^{2}$ for constant $a$ (where $A$ is the Atwood number) and the nonlinear RM growth law $h\ensuremath{\sim}{t}^{\ensuremath{\theta}}$ for impulsive $a,$ where \ensuremath{\alpha} and \ensuremath{\theta} depend on the rate of kinetic energy dissipation. In the case of zero dissipation, $\ensuremath{\theta}=2/3$ in agreement with elementary scaling arguments. A conservative numerical scheme is proposed to solve the model equations, and is used to perform calculations that agree well with published experimental mixing data for four different acceleration histories.
Resistive or dynamic exercise stress testing of the pulmonary circulation and the right heart

There has been recent revival of interest in exercise stress testing of the pulmonary circulation and the right ventricle (RV) for the differential diagnosis of dyspnoea or latent pre- or post-capillary pulmonary hypertension [1–3]. However, guidelines remain cautious because of persistent uncertainties about protocols and the limits of normal [4]. In fact, exercise protocols still vary, with either cycling [3, 6–8], weight lifting [5, 6] or even handgrip [9] modalities, with invasive [3, 5–7, 9] or non-invasive [7, 8, 10] measurements either during [3, 6–10] or after [5] the exercise stress. Furthermore, pulmonary artery pressure (PAP) has been reported either alone [5, 8] or as a function of either cardiac output (CO) [1–3, 7, 10], workload [7, 11] or oxygen uptake (V′O2) [12]. In the meantime, flow-corrected PAP during exercise emerges as the measurement of choice for pulmonary vascular function [1–3], and body position may not matter provided a sufficient number of exercise pressure-flow coordinates is generated to smoothen out higher baseline pulmonary vascular resistance (PVR) in the upright position [10], but there remains uncertainty about the most relevant measurements of RV function [7, 13, 14]. Although there is a rationale in favour of incremental dynamic exercise, there is currently no consensus about the optimal exercise modality. We therefore compared the cardiovascular and gas exchange effects of resistive (handgrip), mixed resistive/dynamic (weight lifting) or dynamic (cycling) exercise on the pulmonary circulation and the RV in healthy volunteers. Exercise stress testing of the pulmonary circulation and the right heart should be dynamic, not resistive http://ow.ly/ZEyF30c9RlP
Low-loss high-isolation 60-80 GHz GaAs SPST PIN switch

A low-loss high-isolation GaAs SPST PIN diode switch for millimeter wave applications is presented. Modeling of PIN diode switches using full-wave electromagnetic simulators by including the semiconductor properties of the diode mesa layers is explained. This approach eliminates the necessity of model extraction from measurements in most cases. In addition, usage of simulation tools allows the optimization of diode structure for minimum insertion loss. Main loss mechanisms of GaAs PIN diodes at mm-wave frequencies are explained. Measurement results of a newly developed CPW SPST 55-85 GHz GaAs PIN switch are presented and compared with simulations. The developed shunt switch has 0.6 dB insertion loss and 20 dB return loss in the off state (through) at 75 GHz. It has 20 dB insertion loss and 1 dB return loss in the on state (isolation) at the same frequency.
Is Atypical Squamous Cells That Cannot Exclude High-grade Squamous Intraepithelial Lesion Clinically Significant?

Objective. To determine the cumulative risk of cervical intraepithelial neoplasia (CIN) 2 or 3 in patients with atypical squamous cells, cannot exclude HSIL (ASC-H). Methods. A retrospective analysis was performed to identify patients referred to the dysplasia clinic with ASC-H. Initial evaluation included colposcopy, endocervical curettage, and an ectocervical biopsy, when indicated, in all the patients. A follow-up evaluation was performed at 6 and 12 months. Cumulative histological diagnosis of CIN 2 or 3 at 12 months served as the clinical end point. Results. Two hundred twenty-nine patients with ASC-H and with a mean age of 32.8 years were evaluated. At the time of initial colposcopy, only 10.0% (23/229; 95% CI = 6.5%-15%) of the patients had histological evidence of CIN 2 or 3. The cumulative risk of CIN 2 or 3 was 12.2% (95% CI = 8%-17%). Conclusions. Evaluation of patients with ASC-H with colposcopy does lead to the detection of CIN 2 or 3 but perhaps at a rate lower than previously reported.
Preliminary data on the association among the serotonin transporter polymorphism, subjective alcohol experiences, and drinking behavior.

OBJECTIVE Individual differences in subjective responses to alcohol are believed to have a genetic basis and have been associated with increased risk of alcohol-related problems. There are, however, conflicting results from past studies, perhaps owing to differences in subjective alcohol effects by limb of the blood alcohol curve and the passage of time. The current pilot study evaluated relations among serotonin transporter (SERT) genotype, subjective alcohol responses, and drinking behavior across both the ascending and descending limbs of the blood alcohol curve. METHOD Participants (N=222; 68% male) were administered alcohol (target blood alcohol concentration of .06%) with a subsample (n=86) providing genetic data. Following a social stressor, participants were provided the opportunity to engage in ad libitum alcohol consumption. RESULTS SERT transporter was not significantly associated with ad lib drinking or subjective alcohol effects at individual time points, although a trend toward a SERT by blood alcohol concentration limb interaction was observed for ad lib drinking. In addition, SERT genotype predicted acute tolerance to alcohol effects, with participants homozygous for the long SERT allele developing acute tolerance more rapidly than other genotypes. CONCLUSIONS Although SERT genotype was not reliably associated with ad lib drinking behavior, the results suggest that individuals with the long-long (LL) genotype may develop acute tolerance to alcohol effects more rapidly than heterozygotes or individuals homozygous for the short SERT allele.
AMBRA1: When autophagy meets cell proliferation

A growing amount of evidence reported in the literature in recent years strongly supports the relevance of the interplay between autophagy and other pathways. In this context, the study of the link between autophagy and cell proliferation regulation has been among the most challenging. In our recent publications, we finely characterize a role for the pro-autophagic protein AMBRA1 in the regulation of cell proliferation. AMBRA1 modulates autophagy and interacts with PPP2/PP2A (protein phosphatase 2), thus also modulating MYC protein levels and the cell proliferation rate. Interestingly, this pathway of regulation is controlled by the master regulator of autophagy and cell growth, MTORC1. Notably, in our study we demonstrate the relevance of the AMBRA1-mediated regulation of MYC in tumorigenesis, also identifying AMBRA1 as a tumor suppressor gene.
Methicillin-resistant Staphylococcus aureus carrying the mecC gene: emergence in Spain and report of a fatal case of bacteraemia.

OBJECTIVES Methicillin-resistant Staphylococcus aureus (MRSA) strains carrying the mecC gene have been reported from humans and animals from several European countries, but never from Spain. We describe the first isolates of mecC-positive MRSA of human origin collected in Spain and report a fatal case of bacteraemia. METHODS Isolates were tested for phenotypic resistance using cefoxitin, tested for the mecA/mecC genes and toxin genes by PCR, and typed by staphylococcal cassette chromosome mec (SCCmec), PFGE, spa, multilocus sequence typing and agr. RESULTS During 2008-13 five MRSA isolates showing resistance to cefoxitin and carrying the mecC gene were recovered at one hospital in Spain. In a review of 5505 S. aureus strains received at the Spanish National Reference Centre for Staphylococci from the same period, we found two additional mecC-positive isolates. The isolates were recovered from blood (two), wounds (two), joint fluid (one), urine (one) and a nasal swab (one). All MRSA were mecA negative, presented SCCmecXI, belonged to agr group III and to clonal complex 130, and were negative for the production of the toxin genes tst1, eta, etb, etd and Panton-Valentine leucocidin. Six isolates belonged to spa type t843 (ST130 and ST1945, where ST stands for sequence type) and one to spa type t6220 (ST1945). One patient with mecC-positive MRSA sepsis died in the emergency department. CONCLUSIONS We confirm the presence of MRSA carrying the mecC gene in Spain, the ability of this livestock-associated MRSA to cause severe infections in humans and the need to perform culture-based susceptibility testing methods in order to detect these emerging strains.
Systemic treatment of HER2+ metastatic breast cancer: Clinical conundrums and future perspectives

Improvements in the treatment of metastatic HER2‐positive breast cancer constitute one of the great advances in breast cancer medicine of the last generation. From being a highly aggressive fatal condition, the use of anti‐HER2‐targeted therapies, in particular trastuzumab, has led to significant improvements in disease outcomes. There are reports of increasing numbers of patients alive and well more than 5 years from diagnosis of metastatic disease.
Reconciling the epidemiology, physiology, and molecular biology of colon cancer.

A QUESTION relevant to the etiology of cancer that is seldom asked is: What gets cancer—the genes, the cell, the organ, the organism, or perhaps even the population? The potential answers are not necessarily exclusive, even given reductionist tendencies and the genuine and justified excitement over discoveries in the molecular biology of cancer. Rather, these arelevelsof explanation that may be more or less coherent within themselves but provide even more information when they exist in a framework provided by all of the explanatory modes. For the purpose of exemplifying this framework, consider that theories of the etiology of colon cancer have been presented at a number of levels—epidemiologic, physiological, and cellular/ molecular. It is proposed herein that it is worthwhile considering both the coherence and interdependence of these levels of explanation, not as a sterile exercise, but because of its heuristic value and its capacity to shape a
Choosing and getting started with a cognitive architecture to test and use human-machine

As these models and modeling mature, we will have an approach that can be used to evaluate and test a wide range of interfaces by simulating the human component of the system, and how humans interact with interface and machine components. The requirements for this approach can sketched (Kieras, 2003; Ritter, Van Rooy, & St. Amant, 2002) and point to early examples (Byrne, Wood, Sukaviriya, Foley, & Kieras, 1994; Kieras, Wood, Abotel, & Hornof, 1995).
An Error-resilient Image Coding and Packetization Scheme for Packet-switched Networks

An error-resilient image coding and fixed-length packetization scheme is presented to prevent packet loss from packet-switched networks. A wavelet coder based on set partition in hierarchy trees (SPIHT) algorithm encodes the wavelet coefficients into an embedded bitstream along with markers generated to record the order of bits within the bitstream. A fixed-length packetization scheme based on the error-resilient entropy code (EREC) is proposed to pack the encoded bitstream into fixed-length packets which can be transmitted over the physical packet-switched network. Any lost packets only have minor effects on other received packets. Computer simulations show that our proposed method provides both excellent compression performance with fast speed and graceful degradation under various packet erasure rates (PER)
Familial cancer risks to offspring from mothers with 2 primary breast cancers: Leads to cancer syndromes

The nationwide Swedish Family‐Cancer Database was used to analyse the risk of cancer among the offspring of bilateral breast cancer patients. We studied 4,734 such mothers who had 9,391 offspring, of whom 328 presented with a primary cancer in the years 1958–1996. Standardised incidence ratios (SIRs) were increased for breast [SIR 3.05, 95% confidence interval (CI) 2.57–3.59], ovarian (SIR 1.84, 95% CI 1.03–3.05) and anogenital (SIR 1.75, 95% CI 1.11–2.63) cancers and childhood sarcomas (SIR 9.39, 95% CI 1.93–29.13). Additionally, squamous‐cell skin cancer was increased among sons and all childhood cancers among daughters. When analysed by histological type, adenocarcinomas of the breast and ovary, all squamous‐cell carcinomas and tumours at glandular epithelium (seminomas and intestinal carcinoids) were increased. Mothers with bilateral breast cancer had an excess of 2 or more children with cancer. The increased risk of ovarian cancer is consistent with germline mutations in the BRCA1 and BRCA2 genes, while the risk of soft tissue and bone sarcomas may reflect the association of these tumours with Li‐Fraumeni syndrome. The increases in squamous‐cell carcinomas at many sites may reflect a new susceptibility syndrome. Int. J. Cancer 88:87–91, 2000. © 2000 Wiley‐Liss, Inc.