Miracle-dz/UniFAR-FTUs huggingface dataset:
Videojuegos: Incentivos Multisensoriales Potenciadores de las Inteligencias Múltiples en Educación Primaria

Introduccion. La investigacion se centro en estudiar en que medida los videojuegos educativos, utilizandolos planificada y sistematicamente, pueden constituir contextos de aprendizaje propicios para desarrollar las Inteligencias Multiples (IM) en escolares. Metodologia. Se adopto una dualidad metodologica: a) cualitativa: evaluacion previa y analisis de contenido del videojuego a utilizar en la experiencia, primando su adecuacion y correspondencia con las areas curriculares de primaria; b) experimental: estudio de caso orientado a constatar el posible incremento de las IM en alumnos de Primer Ciclo de Educacion Primaria (N=101) derivado de la implementacion del videojuego en el aula durante un curso, utilizando un grupo de control e identificando el nivel alcanzado antes (test) y despues de la experiencia (postest) con un instrumento de evaluacion. Resultados. La seleccion previa del videojuego garantiza la adquisicion y refuerzo de numerosos aprendizajes vinculados con los contenidos curriculares de Primaria. Las actividades ludicas -relacionadas con las ocho inteligencias- suponen retos motivadores para los escolares y ocasiones para potenciar diversas habilidades. Tras la experiencia ludico-formativa con el videojuego se observo un incremento generalizado en todas las inteligencias, resultando significativas la logico-matematica, la viso-espacial y la corporal-cinestesica, mejorando las dos primeras mas en las ninas, que en los ninos. Conclusiones. Se verifico la hipotesis de partida: la introduccion de videojuegos educativos adecuados en las aulas y su explotacion sistematica promueve el desarrollo de las IM en escolares de primaria. Especialmente, las operaciones de medida, calculos matematicos, recuentos, identificacion y clasificacion de formas y tamanos, relaciones y correspondencias, junto a actividades que fomentan el cuidado del cuerpo (dieta saludable e higiene personal) presentados de forma ludica facilitan el aprendizaje e incrementan las IM
Capturing transparency-related requirements patterns through argumentation

Transparency is a critical concern to democratic societies. As software permeates our social lives, Software Transparency is becoming a quality criterion that demands more attention from software developers. We present in this paper our approach to capture transparency-related requirements patterns through argumentation. We represented initial transparency knowledge as requirements patterns. These initial patterns stimulated stakeholders' arguments on an open discussion about transparency of a given software. We apply an argumentation framework to capture the stakeholders' arguments on argumentation graphs. Transparency-related requirements patterns are identified by formally analyzing consensus on the argumentation graph. Basically, the identified patterns are possible operationalizations to transparency-related softgoals.
Time Estimation by Psychiatric Patients

The purpose of the present study was to determine whether psychiatric patients reporting intense and/or frequent feelings of time distortion, as well as other derealization (D.R.) and depersonalization (D.P.) symptoms, differ from matched controls in their ability to estimate 1 sec. , using the modified method of limits described by Lhamon and Goldstone (1956). In a previous study of 20 psychiatric patients reporting time distortion as well as other D.P. and D.R. symptoms, Cappon and Banks (1964) found that patients did not significantly differ from matched controls on the traditional tests of time estimation by production, reproduction, or verbal estimation. However, using a modified method of limits, Lhamon and Goldstone (1956) found that schizophrenics compared with controls, overestimated short auditory durations to a greater degree when comparing input co their concept of 1 sec. In view of their results, it was decided to use their method of time estimation in order to compare the performance of patients reporting time distortions with controls. It was hoped that the method would be more sensitive than the traditional methods we used (1964). The second estimation points (SEPs) of two groups of 15 Ss each, psychiatric patients reporting feelings of time distortion and other D.R. and D.P. symptoms and matched non-patient controls, were compared. Patients were matched with controls in terms of sex, age, and years of schooling. The apparatus was an interval timer wired to an ordinary door buzzer, both operated by a silent push-button switch. The procedure and method of scoring were identical with those used by Lhamon and Goldstone (1956). Each S, tested individually, was asked to judge ascending and descending series of auditory durations as more or less than one clock second. The data for each S were plotted on normal probability paper and a besc-fitting straight line was drawn, from which a SEP was derived. The Msrr- for patients was . 85 and for [he matched controls, . 81 (t = .02, df = 14, P > 0.9). Thus the method of limits was no more successful than were the traditional methods of time estimation in differentiating patients who reported time distortion from controls. The results also indicate that reported feelings of time distortion do not necessar~ly affect objective judgments of short auditory durations. These results agree with rhe su,ci;csrlon of Goldstone and Goldfarb (1962) ". that the shorter SEP with schizophren~cs is specifically related to the disease and not to chronic illness or psychiatric disorder. " The results also agree with Cappon and Banks' previous findings (1965) that reporred feelings of disorientation, inclusive of time, do nor necessarily result in judgments significantly different from those made by non-time distorters or non-patient controls.
Proving to the Coincidence of the Solutions of the Modified Problem with the Original Problem of Multi-class Support Vector Machine

Vojtech Franc and Vaclav Hlavac proposed a transformation from the multi-class support vector machine problem to the one-class support vector machine problem which is more convenient for optimization. Moreover, the proposed transformation can be performed by the properly defined kernel function only. The experiments conducted indicate that the proposed method is comparable with the one-against-all decomposition solved by the state-of-the-art sequential minimal optimizer algorithms. This paper proves strictly with theory that the solution of the one-class support vector machine problem coincides mostly with the solution of the multi-class support vector machine problem.
A mouse model for EML4-ALK-positive lung cancer

EML4-ALK is a fusion-type protein tyrosine kinase that is generated in human non-small-cell lung cancer (NSCLC) as a result of a recurrent chromosome inversion, inv (2)(p21p23). Although mouse 3T3 fibroblasts expressing human EML4-ALK form transformed foci in culture and s.c. tumors in nude mice, it has remained unclear whether this fusion protein plays an essential role in the carcinogenesis of NSCLC. To address this issue, we have now established transgenic mouse lines that express EML4-ALK specifically in lung alveolar epithelial cells. All of the transgenic mice examined developed hundreds of adenocarcinoma nodules in both lungs within a few weeks after birth, confirming the potent oncogenic activity of the fusion kinase. Although such tumors underwent progressive enlargement in control animals, oral administration of a small-molecule inhibitor of the kinase activity of ALK resulted in their rapid disappearance. Similarly, whereas i.v. injection of 3T3 cells expressing EML4-ALK induced lethal respiratory failure in recipient nude mice, administration of the ALK inhibitor effectively cleared the tumor burden and improved the survival of such animals. These data together reinforce the pivotal role of EML4-ALK in the pathogenesis of NSCLC in humans, and they provide experimental support for the treatment of this intractable cancer with ALK inhibitors.
Miller Theorem for Weakly Nonlinear Feedback Circuits and Application to CE Amplifier

The paper presents the derivation of Miller formulas for weakly nonlinear feedback networks. The expressions found are simple and compact and constitute a generalization of the well- known linear case. As an application example, the formulas are applied to a common-emitter amplifier to straightforwardly derive the closed-form expressions of second- and third-harmonic distortion factors. The results found, validated by Spectre simulations with a VBIC bipolar model, allow to understand in depth the contribution of each nonlinear element.
Hyperinsulinaemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and is one of the leading causes of cancer‐related death. The risk factors for HCC include cirrhosis, chronic viral hepatitis, heavy alcohol intake and metabolic diseases such as obesity, type 2 diabetes and metabolic syndrome. Insulin resistance is a common denominator of all of these conditions and is tethered to hyperinsulinaemia. Here, we give an overview of the recent advances linking hyperinsulinaemia to HCC development and progression. In particular, we summarise the underlying causes of hyperinsulinaemia in the setting of chronic liver diseases. We present epidemiological evidence linking metabolic diseases to HCC risk and HCC‐related mortality, as well as the pathogenic cellular and molecular mechanisms explaining this relation. A better understanding of the mechanisms by which insulin participates in HCC biology might ultimately provide novel opportunities for prevention and treatment.
Surveillance of Avian Coronaviruses in Wild Bird Populations of Korea

Abstract We examined the role of wild birds in the epidemiology of avian coronaviruses by studying oropharyngeal swabs from 32 wild bird species. The 14 avian coronaviruses detected belonged to the gamma-coronaviruses and shared high nucleotide sequence identity with some previously identified strains in wild waterfowl, but not with infectious bronchitis viruses.
Pressure-induced unfolding/refolding of ribonuclease A: static and kinetic Fourier transform infrared spectroscopy study.

In this paper, we illustrate the use of high-pressure Fourier transform infrared (FT-IR) spectroscopy to study the reversible presssure-induced unfolding and refolding of ribonuclease A (RNase A) and compare it with the results obtained for the temperature-induced transition. FT-IR spectroscopy monitors changes in the secondary structural properties (amide I' band) or tertiary contacts (tyrosine band) of the protein upon pressurization or depressurization. Analysis of the amide I' spectral components reveals that the pressure-induced denaturation process sets in at 5. 5 kbar at 20 degrees C and pH 2.5. It is accompanied by an increase in disordered structures while the content of beta-sheets and alpha-helices drastically decreases. The denatured state above 7 kbar retains nonetheless some degree of beta-like secondary structure and the molecule cannot be described as an extended random coil. Increase of pH from 2.5 to 5.5 has no influence on the structure of the pressure-denatured state; it slightly changes the stability of the protein only. All experimental evidence indicates that the pressure-denatured states of monomeric proteins have more secondary structure than the temperature-denatured states. Different modes of denaturation, including pressure, may correlate differently with the roughness of the energy scale and slope of the folding funnel. For these reasons we have also carried out pressure-jump kinetic studies of the secondary structural evolution in the unfolding/refolding reaction of RNase A. In agreement with the theoretical model presented by Hummer et al. [(1998) Proc. Natl. Acad. Sci. U.S.A. 95, 1552-1555], the experimental data show that pressure slows down folding and unfolding kinetics (here 1-2 orders of magnitude), corresponding to an increasingly rough landscape. The kinetics remains non-two-state under pressure. Assuming a two-step folding scenario, the calculated relaxation times for unfolding of RNase A at 20 degrees C and pH 2.5 can be estimated to be tau(1) approximately 0.7 min and tau(2) approximately 17 min. The refolding process is considerably faster (tau(1) approximately 0.3 min, tau(2) approximately 4 min). Our data show that the pressure stability and pressure-induced unfolding/refolding kinetics of monomeric proteins, such as wild-type staphylococcal nuclease (WT SNase) and RNase A, may be significantly different. The differences are largely due to the four disulfide bonds in RNase A, which stabilize adjacent structures. They probably lead to the much higher denaturation pressure compared to SNase, and this might also explain why the volume change of WT SNase upon unfolding is about twice as large.
Consensus in inventory games

This paper studies design, convergence, stability and optimality of a distributed consensus protocol for n-player repeated non cooperative games under incomplete information. Information available to each player concerning the other players' strategies evolves in time. At each stage (time period), the players select myopically their best binary strategy on the basis of a payoff, defined on a single stage, monotonically decreasing with the number of active players. The game is specialized to an inventory application, where fixed costs are shared among all retailers, interested in reordering or not from a common warehouse. As information evolves in time, the number of active players changes too, and then each player adjusts its strategy at each stage based on the updated information. In particular, the authors focus on Pareto optimality as a measure of coordination of reordering strategies, proving that there exists a unique Pareto optimal Nash equilibrium which verifies certain stability conditions. The main contribution of the paper is the design of a consensus protocol allowing the distributed convergence of the strategies to the unique Pareto optimal Nash equilibrium. Results may also be extended to externality games, pollution/congestion games, and cost-sharing games, with the only constraint of being the strategies binary and with threshold structure.
Reverse Image Search Engine using Compact Composite Descriptor

With the massive growth of World Wide Web people are able to gain the access to massive amount of information. This information may contain data, images, flow charts, logos, maps etc. However locating and finding the relevant information is always a difficult task. A lot of textual-based search engines are available, but there are very rare image search engines through which desired images can be searched from the pool of images available on the web. Hence there is a need of such a image search engine using which the related and exact images can be searched. Reverse image search is such a content-based image retrieval query technique that involves providing the CBIR system with a sample image that it will then base its search upon. Reverse image search can be used to search either data related to the query image or the images related to that image or exact images.
Heuristics-based entity-relationship modelling through natural language processing

Here we propose new heuristics that assist the semi-automated generation of Entity-Relationship (ER) diagrams for database modelling from a natural language description and describe the implementation of such a system called ER-Converter . Though this is a semi-automatic transformation process, ER-Converter aims to require minimal human intervention during the process. ER-Converter has been evaluated in blind trials against a set of database problems. ER-Converter has an average of 95% recall and 82% precision. The evaluation results are discussed and demonstrate that ER-Converter could be used, for example, within the domain model of a multimedia intelligent tutoring system, designed to assist in the learning and teaching of databases.
Flat-shaped, front-face-drive scent projector

In this study, a hardware configuration for reducing the size of a scent projector is proposed, and its performance is examined using a prototype system. A scent projector is a system that delivers a small amount of scented air to the user's nose by channeling the scent through a vortex ring. A projector enables scents to be presented locally in time and space without requiring the user to wear any special apparatus. Such localization is important when scents are presented synchronously with other sensory stimuli. However, scent projectors make use of so-called “air cannons” that usually have significant volume, making their size a major drawback. To solve this problem, we examined the principal parameters that affect the performance of a scent projector, and found that the inner volume of the air cannon does not seriously affect the range of a vortex ring. Based on this analysis, we designed a flat-shaped scent projector that has zero volume in the idle state and built a prototype system. Our prototype performed almost as well as existing scent projectors with larger volume.
Alternative splicing dictates translational start in Epstein‐Barr virus transcripts.

Of the 10 viral genes known to be expressed during Epstein‐Barr virus (EBV) latency, six encode nuclear antigens (EBNAs), all of which are expressed from a long primary transcript by means of alternative splicing and alternative polyadenylation sites. The primary transcript is generated by either of two promoters which operate in a mutually exclusive fashion in different clonal cell lines. All mRNAs from either promoter have exons in common from the BamHI W viral genomic fragment (the major internal repeat, IR1) which encode the N‐terminal portion of one of the nuclear antigens (EBNA 4). In addition to the coding regions for EBNA 4, EBNA mRNAs encode another EBNA (i.e. EBNA 1, 2, 3A, 3B or 3C) downstream. We show that alternative splicing determines whether the translation initiation codon for EBNA 4 is present or absent, thus permitting the generation of mRNAs in which the first translation initiation codon is either that for the EBNA 4 gene or for the other EBNA gene encoded downstream. This mechanism presumably ensures efficient translation of all the EBNA genes.
Cooperative human-robot control based on Fitts' law

Many studies on human motor control have examined how humans move the arms. A well known phenomenon known as the Fitts' law describes the trade-off between the speed of motion and its accuracy. In robotics, many studies were performed, and different control methods were proposed, for robots working in well structured environments. Nevertheless, the cooperation between humans and robots remains a challenging task that is highly relevant for robots aiming to work together with humans in non-structured environments. In this paper we propose a novel method for on-line adaptation of robotic trajectories, where humans and robots are autonomous agents coupled through physical interaction, for example through manipulated object. Within the proposed framework, the robot adapts to the human motion through the sensory feedback by taking into account the Fitts' law where the user specific behavior is estimated using a recursive least square updates. The movement trajectories are represented by the Dynamic Movement Primitives, where the adaptation relies on the Iterative Learning Controller framework. The proposed approach was evaluated by a cooperative human robot arm-reaching task on a plane. We tested the accuracy and efficiency of the proposed method, showed its relevance and demonstrated that the proposed approach fully adapts to the human motor control and maintains the desired accuracy of the movement.
Weak acid adaptation: the stress response that confers yeasts with resistance to organic acid food preservatives.

Frequently the decomposing plant materials where fungi grow as saprophytes will contain high concentrations of weak organic acids. Not only are acetate and lactate products of bacterial fermentation, but acetate is also secreted in high levels by certain yeasts, such as the Brettanomyces and Dekkera that have attracted attention as spoilage agents of wine fermentations (Pretorius, 2000). Saccharomyces cerevisiae is frequently inhibited by these acids produced by competitor microbes. To counteract their effects, it is endowed with a stress response that acts to reduce the possibility that the weak acid will accumulate within its cells to high, potentially toxic, levels.
On Stochastic Stability of Packetized Predictive Control of Non-Linear Systems Over Erasure Channels

We study a predictive control formulation for discrete-time non-linear plant models where controller output data is transmitted over an unreliable communication channel. The channel is affected by random data-loss and does not provide acknowledgments of receipt. To achieve robustness with respect to dropouts, at every sampling instant the controller transmits packets of data. These contain possible control inputs for a finite number of future time instants, and minimize a finite horizon cost function. At the plant actuator side, received packets are buffered, providing the plant inputs. Within this context, we adopt a stochastic Lyapunov function approach to establish stability results of this networked control system.
Cost effective resonant DC-DC converter for hi-power and wide load range operation

This paper describes an original topology for a stepdown DC-DC converter. This converter is a resonant converter with zero voltage switching and zero current switching. Regulation of the converter is done by PWM and variable frequency; this provides good regulation, from no load to full load. A prototype was built for an output power of 4 kW, an input voltage range of 280 VDC to 440 VDC, and an output voltage of 14 VDC. The prototype converter has an efficiency of 92-94%, is cost effective, and a good fit for high power and high current applications. The authors suggest that the presented topology is a better alternative to a typical phase-shift topology, with an additional advantage of being bi-directional
Simultaneous Liver–Kidney Transplantation Summit: Current State and Future Directions

Although previous consensus recommendations have helped define patients who would benefit from simultaneous liver–kidney transplantation (SLK), there is a current need to reassess published guidelines for SLK because of continuing increase in proportion of liver transplant candidates with renal dysfunction and ongoing donor organ shortage. The purpose of this consensus meeting was to critically evaluate published and registry data regarding patient and renal outcomes following liver transplantation alone or SLK in liver transplant recipients with renal dysfunction. Modifications to the current guidelines for SLK and a research agenda were proposed.