Miracle-dz/UniFAR-FTUs huggingface dataset:
Ghost imaging in the frequency domain with a high brilliance coherent monochromatic source: a novel approach to extend spectroscopy sensitivity beyond detectors limits

Ghost imaging is an active technique that implies using a time-varying structured illumination source to image a target without spatially-resolving measurements of the light beam that interacts with the target. Traditionally, a beam splitter is used to create two highly correlated beams, such that the signal interacts with the target and is then measured by a single pixel detector, while the reference is directly measured by a spatially resolving detector. This approach allows to implement ghost imaging in the space domain, nevertheless also temporal and frequency domains can be addressed1,2, allowing to extract the pertinent information. In particular, ghost imaging in the frequency domain has been recently applied to extract spectral information from a target object by means of Fourier Transform Interferometry3,4. In this work we illustrate and discuss the results of interaction-free measurements on an Er3+ doped nonlinear crystal, placed in one arm of an interferometer, obtained by using only non-interacting photons. Our equipment is a wave-guided solid state device, exploiting an integrated quantum photonic circuit that is equivalent to an Asymmetric Nonlinear Mach-Zehnder Interferometer. The experiment was performed by using a 250mW monochromatic 980 nm laser source that allowed exciting an Er:LiNbO3 waveguide, placed in one of the arms of the asymmetric interferometer. The interferograms were obtained by varying the signal in the time domain by using a LiNbO3 undoped waveguide in the opposite branch of the interferometer and recorder with a standard Si p-i-n detector, provided with a pass band filter (975nm ± 25nm) thus blocking all photons except the pump ones. The data were analyzed with conventional Fast Fourier Transform Techniques. The application of this approach allowed to recover information in the frequency domain, in particular, despite the monochromatic characteristics of the detected signal, we could recover the whole spectroscopy of the energy levels of the Er3+ doped crystal. The role of the converted photons was evidenced by the fact that, by using a radiation source that does not interact with the dopant (1320nm Laser), only the line of the source is recovered by the FFT handling of the interferograms. An important aspect to remark is that the obtained spectral distribution addressed also the IR part of the spectrum where the applied detector (Si p-i-n) is blind. In this view, this methodology opens the possibility to extend sensitive spectral measurements in spectral regions where detectors show poor responsivity.
Why orthotropic friction is important on graphene and graphene fluoride thin films

We experimentally demonstrate that graphene and graphene fluoride manifest different coefficients of sliding friction at the edges (graphene fluoride from 5.8×10-3 to 4.9×10-1; graphene from 8.2×10-3 to 3.3×10-1) of a sheet sample versus the interior (graphene fluoride from 5.1×10-3 to 1.5×10-1; graphene from 2.5×10-2 to 2.3×10-1) under ambient humidity conditions (~ 40-60%). Atomic force microscopy (AFM) was used to prove the friction coefficients show distinct directional dependence between graphene and graphene fluoride.
Age group influence for effectiveness study of color symbol scheme on choropleth map of population density in special region of Yogyakarta

Map can show information needed by map users from various scientific fields, especially in Indonesia. Effective maps can help users understand. One of the factors that influence the effectiveness of map reading is the color symbol scheme used in symbolization. Effectiveness’ study of color symbol scheme applied on choropleth mapping. Choropleth map is using population density data in Special Region of Yogyakarta. The selection of the study area in the Special Province of Yogyakarta is because the Special Region of Yogyakarta is one of the provinces in Indonesia which has a fairly high population density in the area of 3,185.80 km2 . In 2016, the population density of the Special Province of Yogyakarta ranked 4th in the Indonesian Statistics 2017 by the Central Bureau of Statistics, which amounted to 1,188 population per km2 . The effectiveness of color symbol schemes adapts the capabilities of each user. This study is expected to be able to study the effect of age group differences on maps with the best color symbol scheme. All scientific field that used choropleth map of population density consist of 2 age groups, those are 20-25 years old and >5 years old respondents. The purpose of this study was to observe age group influence for the most effective color symbol scheme for mapping population density in the Special Region of Yogyakarta. The result of this study shows the difference between age group based on the important aspects of conventional-eye tracking. The important aspects to consider are average answering duration, the accuracy of the answer and easiness level of symbolization readings. The first group (20-25 years) shows map 3 (diverging color scheme) as a map with the most effective color symbol scheme. While group 2 (>25 years) shows map 1 (ArcGIS 10.3 color scheme) as a map with the most effective color symbol scheme. This research is expected to be able to show the influence of age in determining the best color symbol scheme on population density maps so that its effectiveness can be adjusted specifically to map users.
Sustainable Development for Shipping Companies: A Supply Chain Integration Perspective

ABSTRACT Ji, H. ; Sui, Y. , and Wang, H. , 2019. Sustainable development for shipping companies: A supply chain integration perspective. In: Li, L. ; Wan, X. ; and Huang, X. (eds.), Recent Developments in Practices and Research on Coastal Regions: Transportation, Environment and Economy. Journal of Coastal Research Journal of Coastal Research, Special Issue No. 98, pp. 339–343. Coconut Creek (Florida), ISSN 0749-0208. With the increase of international competition and environmental protection requirements, sustainable development has become a key condition for the international competitiveness of shipping companies. This study used innovative behavior as a mediator to construct a supply chain integration mechanism for shipping companies and to promote the sustainable development of enterprises. Path analysis and hypothesis testing were performed based on structural equations. A survey of 287 samples of shipping companies was conducted through field surveys and internet questionnaires. This research shows that external integration and internal integration of the supply chain have a positive impact on the sustainable development of shipping companies through enterprise innovation. Finally, the article expounds on the management significance of this mechanism for the sustainable development of shipping companies.
Analysis and Comparison of Input and Output Benefits of Marine Science and Technology in Coastal Provinces of China

ABSTRACT Bai, R. , 2019. Analysis and comparison of input and output benefits of marine science and technology in coastal provinces of China. In: Li, L. ; Wan, X. ; and Huang, X. (eds.), Recent Developments in Practices and Research on Coastal Regions: Transportation, Environment and Economy. Journal of Coastal Research, Special Issue No. 98, pp. 311–313. Coconut Creek (Florida), ISSN 0749-0208. Using the data envelopment analysis method, the input and output efficiency of marine science and technology were compared in five coastal provinces of China. Based on the analysis of the relationships among the number of marine scientific research institutions, the total income of marine scientific research institutions, the number of employees of marine scientific research institutions, the number of topics studied by marine scientific research institutions, the number of invention patents, and the publication of scientific and technological papers, the benefits of scientific and technological input and output are compared and analyzed.
Dementia and the heart failure patient

Abstract Heart and brain disorders more frequently co-exist than by chance alone, due to having common risk factors and a degree of interaction. In the setting of heart failure (HF) in the elderly strokes, dementia, and depression are all common and can produce a particularly difficult series of clinical problems to manage. Loss of ability to self-care can lead to very poor quality of life and a dramatic increase in health care expenditure. The Heart Failure Association of the ESC as part of its workshop on physiological monitoring of the complex multi-morbid HF patient reviewed screening, monitoring, prevention, and management of cognitive decline within the setting of HF.
Ageing, demographics, and heart failure

Abstract Heart failure (HF) is a complex clinical syndrome resulting from structural or functional cardiac disorders. In the developed world, HF is primarily a disorder of the elderly. It is one that is accompanied by many non-cardiac comorbidities that affect treatments given, the patient’s response and treatment tolerance and outcomes. Even the pathophysiological mechanisms of HF change as we look at older patient populations. Younger HF patients typically have ischaemic heart disease and HF with reduced ejection fraction (HFrEF), whereas older patients have more hypertension HF with preserved ejection fraction (HFpEF). The prevalence of HF has progressively increased for many years and rises even more steeply with age. The outcomes of older especially HFpEF patients have not progressed as much younger HFrEF cohorts. We need more studies specifically recruiting older HF patients with more comorbidities, to guide real-world practice, and we need more assessment of patient-reported outcomes and quality of life rather than just mortality effects. The management of elderly patients with HF requires a more holistic approach recognizing individual needs and necessary support mechanisms and our future trials need to guide us more in achieving these gains.
Changes in Body Composition during Adjuvant FOLFOX Chemotherapy and Overall Survival in Non-Metastatic Colon Cancer

The impact of longitudinal anthropometric changes during adjuvant chemotherapy on long-term survival in non-metastatic colon cancer is unclear. Herein, we analyzed the prognostic significance of computed tomography (CT)-measured body composition changes in colon cancer patients who underwent surgery followed by adjuvant FOLFOX (folinic acid, 5-fluorouracil, oxaliplatin) chemotherapy. Data of 167 patients with stage III or high-risk stage II colon cancer were analyzed. Skeletal muscle index (SMI), skeletal muscle radiodensity (SMR), visceral fat index (VFI), subcutaneous fat index (SFI), and total fat index (TFI) changes during chemotherapy were calculated using preoperative and postchemotherapy CT image data. The Cox proportional hazard model was used to determine the correlation between changes in anthropometric values and overall survival (OS). The median changes (%) in SMI, SMR, VFI, SFI, and TFI over 210 days during chemotherapy were 8.7% (p < 0.001), 3.4% (p = 0.001), −19% (p < 0.001), −3.4% (p = 0.936), and −11.9% (p < 0.001), respectively. Cut-off values of changes in SMI (skeletal muscle index change, SMIC) and SMR (skeletal muscle radiodensity change, SMRC) were defined at −2% and −2 Hounsfield units (HU) respectively, whereas those of changes in VFI (visceral fat index change, VFIC), SFI (subcutaneous fat index change, SFIC), and TFI (total fat index change, TFIC) were based on values that provided the largest χ2 on the Mantel–Cox test. Multivariable analysis revealed that low SMR measured on a postchemotherapy CT scan (hazard ratio, HR: 0.32, 95% confidence interval, CI: 0.15–0.70, p = 0.004) and visceral fat loss of at least 46.57% (HR: 0.31, 95% CI: 0.14–0.69, p = 0.004) were independent poor prognostic factors for OS. Severe visceral fat loss during FOLFOX chemotherapy and low skeletal muscle radiodensity measured on postchemotherapy CT scans are associated with poor OS in stage III and high-risk stage II colon cancer patients.
The functionally relevant site for paxilline inhibition of BK channels

Significance Paxilline (PAX) is a specific BK channel inhibitor that has been widely used in various biophysical and physiological studies involving BK channels. It is also one of a few nonpeptidergic toxins with binding affinity comparable to that of peptidergic toxins. The current study identifies a binding pose of PAX in the closed BK channel that fits all known functional characteristics of PAX inhibition and is confirmed by additional functional tests. This result provides critical information to thoroughly understand the mechanism underlying BK channel inhibition by PAX, which will provide not only important insight into BK channel function, but also valuable guidance in the development of novel ion channel modulators. The tremorgenic fungal alkaloid paxilline (PAX) is a commonly used specific inhibitor of the large-conductance, voltage- and Ca2+-dependent BK-type K+ channel. PAX inhibits BK channels by selective interaction with closed states. BK inhibition by PAX is best characterized by the idea that PAX gains access to the channel through the central cavity of the BK channel, and that only a single PAX molecule can interact with the BK channel at a time. The notion that PAX reaches its binding site via the central cavity and involves only a single PAX molecule would be consistent with binding on the axis of the permeation pathway, similar to classical open channel block and inconsistent with the observation that PAX selectively inhibits closed channels. To explore the potential sites of interaction of PAX with the BK channel, we undertook a computational analysis of the interaction of PAX with the BK channel pore gate domain guided by recently available liganded (open) and metal-free (closed) Aplysia BK channel structures. The analysis unambiguously identified a preferred position of PAX occupancy that accounts for all previously described features of PAX inhibition, including state dependence, G311 sensitivity, stoichiometry, and central cavity accessibility. This PAX-binding pose in closed BK channels is supported by additional functional results.
The Effects of Music-Contingent Gait Training on Cognition and Mood in Parkinson Disease: A Feasibility Study

Background. In Parkinson disease (PD), gait impairments often coexist with nonmotor symptoms such as anxiety and depression. Biofeedback training may improve gait function in PD, but its effect on nonmotor symptoms remains unclear. This study explored the cognitive and global effects of Ambulosono, a cognitive gait training method utilizing step size to contingently control the real-time play of motivational music. Objective. This study examined the feasibility of music-contingent gait training and its effects on neuropsychological test performance and mood in persons with PD. Methods. A total of 30 participants with mild to moderate PD were semirandomized via sequential alternating assignment into an experimental training group or control music group. The training group received 12 weeks of music-contingent training, whereby music play was dependent on the user achieving a set stride length, adjusted online based on individual performance. The control group received hybrid training beginning with 6 weeks of noncontingent music walking, whereby music played continuously regardless of step size, followed by 6 weeks of music-contingent training. Global cognition, memory, executive function, attention, and working memory assessments were completed by blinded assessors at baseline, 6 weeks, and 12 weeks. Motor function, mood, and anxiety were assessed. Results. Average training adherence was 97%, with no falls occurring during training sessions. Improvements on cognitive measures were not clinically significant; however, significant decreases in depression and anxiety were observed in both groups over time (P < .05). Conclusions. Music-contingent gait training is feasible and safe in individuals with PD. Further investigation into potential therapeutic applications of this technology is recommended.
Induction of Human Intestinal and Hepatic Organic Anion Transporting Polypeptides: Where Is the Evidence for Its Relevance in Drug-Drug Interactions?

Organic anion transporting polypeptides (OATPs), expressed in human liver (OATP1B1, OATP1B3, and OATP2B1) and intestine (OATP2B1), govern the pharmacokinetics (PK) of drugs (e.g., statins) and endogenous substrates (e.g., coproporphyrin I [CPI]). Their expression is known to be modulated (e.g., disease, age, and environmental factors), and they also present as the loci of clinically relevant polymorphisms and drug interactions involving inhibition. In comparison, relatively few clinical reports describe the induction of OATPs, although the effect of inducers (e.g., rifampicin [RIF], carbamazepine [CBZ]) on OATP biomarker plasma levels and statin PK has been reported. Of note, available human tissue (e.g., biopsy) protein and messenger RNA expression profiling data indicate that OATPs in gut and liver are not induced by prototypical inducers such as RIF when compared with cytochrome P450 3A4 (CYP3A4), P-glycoprotein (Pgp), multidrug resistance–associated protein 2 (MRP2), and breast cancer resistance protein (BCRP). Such results are consistent with in vitro human hepatocyte data. Therefore, the observed impact of RIF, and possibly CBZ, on statin PK (>20% decrease in the area under the plasma concentration vs. time curve) cannot be ascribed to OATP induction with certainty. In fact, most statins and CPI have been shown to present variously as substrates of RIF-inducible proteins such as CYP3A4, Pgp, MRP2, and BCRP. Interpretation of multidose RIF data is further complicated by its autoinduction, which likely leads to decreased inhibition of OATP. In the absence of more conclusive OATP induction data, caution is needed when modeling drug-drug interactions involving multidose inducers such as RIF. SIGNIFICANCE STATEMENT Presently, there is limited direct clinical evidence supporting the notion that human liver and gut organic anion transporting polypeptides (OATPs) are inducible by agents like rifampicin (RIF). Such data need to be reconciled and will pose challenges for attempting to incorporate OATP induction into physiologically based pharmacokinetics models. Although disparate sets of tissue biopsy (atorvastatin and carbamazepine) and in vitro hepatocyte (phenobarbital, chenodeoxycholate, and amprenavir) data present OATP messenger RNA induction (≥2-fold) by agents beyond RIF, the clinical relevance of such data needs to be determined.
Effect of Mesoporous Silica Nanoparticles on The Physicochemical Properties of Pectin Packaging Material for Strawberry Wrapping

Citrus peel pectin was used to prepare films (cast with or without glycerol) containing mesoporous silica nanoparticles. Nanoparticles reduced significantly the particle size, and had no effect on the Zeta potential of pectin solutions. Mechanical characterization demonstrates that pectin+nanoparticles containing films slightly increased tensile strength and significantly decreased the Young’s modulus in comparison to films made only of pectin. However, elongation at the break increased in the pectin+nanoparticles films cast in the presence of glycerol, while both Young’s modulus and tensile strength were reduced. Moreover, nanoparticles were able to reduce the barrier properties of pectin films prepared with or without glycerol, whereas positively affected the thermal stability of pectin films and the seal strength. The 0.6% pectin films reinforced or not with 3% nanoparticles in the presence of 30% glycerol were used to wrap strawberries in order to extend the fruit’s shelf-life, over a period of eighty days, by improving their physicochemical properties.
A Time-of-Flight Range Sensor Using Four-Tap Lock-In Pixels with High near Infrared Sensitivity for LiDAR Applications

In this paper, a back-illuminated (BSI) time-of-flight (TOF) sensor using 0.2 µm silicon-on-insulator (SOI) complementary metal oxide semiconductor (CMOS) technology is developed for long-range laser imaging detection and ranging (LiDAR) application. A 200 µm-thick bulk silicon in the SOI substrate is fully depleted by applying high negative voltage at the backside for higher quantum efficiency (QE) in a near-infrared (NIR) region. The proposed SOI-based four-tap charge modulator achieves a high-speed charge modulation and high modulation contrast of 71% in a NIR region. In addition, in-pixel drain function is used for short-pulse TOF measurements. A distance measurement up to 27 m is carried out with +1.8~−3.0% linearity error and range resolution of 4.5 cm in outdoor conditions. The measured QE of 55% is attained at 940 nm which is suitable for outdoor use due to the reduced spectral components of solar radiation.
A Single Noninterleaved Metasurface for High‐Capacity and Flexible Mode Multiplexing of Higher‐Order Poincaré Sphere Beams

Cylindrical vector vortex beams, a particular class of higher‐order Poincaré sphere beams, are generalized forms of waves carrying orbital angular momentum with inhomogeneous states‐of‐polarization on their wavefronts. Conventional methods as well as the more recently proposed segmented/interleaved shared‐aperture metasurfaces for vortex beam generation are either severely limited by bulky optical setups or by restricted channel capacity with low efficiency and mode number. Here, a noninterleaved vortex multiplexing approach is proposed, which utilizes superimposed scattered waves with opposite spin states emanating from all meta‐atoms in a coherent manner, counter‐intuitively enabling ultrahigh‐capacity, high‐efficiency, and flexible generation of massive vortex beams with structured state‐of‐polarization. A series of exemplary prototypes, implemented by sub‐wavelength‐thick metasurfaces, are demonstrated experimentally, achieving kaleidoscopic vector vortex beams. This methodology holds great promise for structured wavefront shaping, vortex generation, and high information‐capacity planar photonics, which may have a profound impact on transformative technological advances in fields including spin‐Hall photonics, optical holography, compressive imaging, electromagnetic communication, and so on.
Positional Differences in Peak- and Accumulated- Training Load Relative to Match Load in Elite Football

Quantification of training and match load is an important method to personalize the training stimulus’ prescription to players according to their match demands. The present study used time-motion analysis and triaxial-accelerometer to quantify and compare: a) The most demanding passages of play in training sessions and matches (5-min peaks); b) and the accumulated load of typical microcycles and official matches, by playing position. Players performance data in 15 official home matches and 11 in-season microcycles were collected for analysis. Players were divided into four different playing positions: Centre-backs, wing-backs, centre midfielders, and centre forwards. The results show that match demands were overperformed for acceleration counts (acccounts) (131%–166%) and deceleration counts (deccounts) (108%–134%), by all positions. However, relative to match values, training values for sprint distance (sprintdist) and high-intensity run distance (HIRdist) were considerably lower (36%–61% and 57%–71%) than for accelerations and decelerations. The most pronounced difference on the 5-min peaks was observed in sprints (sprintpeak), with wing-backs achieving during the microcycle only 64% of the sprintpeak in matches, while centre backs, centre midfielders, and centre forwards levelled and overperformed the match values (107%, 100%, and 107%, respectively). Differences observed across playing positions in matches and microcycles underline the lack of position specificity of common training drills/sessions adopted by coaches in elite football.