Miracle-dz/UniFAR-FTUs huggingface dataset:
ONCMIRS: FROM BENCH TO BED SIDE

The biomedical research community now focuses its attention to miRNA due to its significant advantages when compared to siRNA and they are believed to be emergent class of therapeutant. Innumerable evidences support the remarkable link between miRNA and cancer. Hence introducing oncomiRs as therapeutant is certainly an important milestone in cancer therapy. MiRNA replacement therapy and miRNA antagonists have been successful in basic research. But the main drawback to actualize these Superdrug’s is the delivery systems. For miRNA based therapeutics several pre- clinical and clinical based trials were initiated and in this review the status of miRNAs in pre- clinical and clinical trials are described. This review focusses on the journey of miRNA through various phases. In its initial phase it describes the link between miRNA and cancer as well as highlighting its role in cancer stem cells. The journey continues by narrating its introduction to therapeutic field especially the two main strategies miRNA antagonists and mimics with special emphasis on the pharmacological property of miRNA. The journey reaches its destination by introducing the various delivery systems for effective transport of miRNA to target cells and moreover discussing the miRNAs under clinical trials and the various pharmaceutical companies involved in it and furthermore opening new dimensions to small RNA biology.
Dynamic Model and Vibration Power Flow of a Rigid-Flexible Coupling and Harmonic-Disturbance Exciting System for Flexible Robotic Manipulator with Elastic Joints

This paper investigates the dynamic of a flexible robotic manipulator (FRM) which consists of rigid driving base, flexible links, and flexible joints. With considering the motion fluctuations caused by the coupling effect, such as the motor parameters and mechanism inertias, as harmonic disturbances, the system investigated in this paper remains a parametrically excited system. An elastic restraint model of the FRM with elastic joints (FRMEJ) is proposed, which considers the elastic properties of the connecting joints between the flexible arm and the driving base, as well as the harmonic disturbances aroused by the electromechanical coupling effect. As a consequence, the FRMEJ accordingly remains a flexible multibody system which conveys the effects of rigid-flexible couple and electromechanical couple. The Lagrangian function and Hamilton’s principle are used to establish the dynamic model of the FRMEJ. Based on the dynamic model proposed, the vibration power flow is introduced to show the vibration energy distribution. Numerical simulations are conducted to investigate the effect of the joint elasticities and the disturbance excitations, and the influences of the structure parameters and motion parameters on the vibration power flow are studied. The results obtained in this paper contribute to the structure design, motion optimization, and vibration control of FRMs.
UCLA Other Recent Work Title Employment Discrimination Based on Sexual Orientation : A Hong Kong Study Permalink

Various parties have called on Hong Kong to pass legislation proscribing sexual orientation-based employment discrimination. The government has suggested that data on discrimination should inform debate on this matter. This survey of 792 self-identified sexual orientation minorities in Hong Kong examined (1) the prevalence of sexual orientation-based discrimination, (2) risk factors associated with experiencing discrimination, and (3) the relationship between experiencing employment discrimination and psychological outcomes. Nearly one-third of respondents reported discrimination. Rates of discrimination varied by age, education, and level of sexual orientation disclosure. Reports of discrimination were associated with negative psychological outcomes. This paper discusses how these results reinforce calls for legislative action. Limitations and directions for future research are also considered.
Coulomb dissociation ofN20,21

Neutron-rich light nuclei and their reactions play an important role in the creation of chemical elements. Here, data from a Coulomb dissociation experiment on N20,21 are reported. Relativistic N20,21 ions impinged on a lead target and the Coulomb dissociation cross section was determined in a kinematically complete experiment. Using the detailed balance theorem, the N19(n,γ)N20 and N20(n,γ)N21 excitation functions and thermonuclear reaction rates have been determined. The N19(n,γ)N20 rate is up to a factor of 5 higher at T<1GK with respect to previous theoretical calculations, leading to a 10% decrease in the predicted fluorine abundance.
The Constitutional System and Disaster Risk Governance in Taiwan: a Perspective on Institutional Resilience

This article uses institutional resilience theory to explain how Taiwan’s constitutional system absorbs the impact of major governance challenges. The article chooses a major disaster that occurred in recent years in Taiwan, the 921 earthquake, to discuss how a constitutional system operations is reflected in the arrangements, flexibility, and corresponding mechanisms of the governance process. This article argues that as one of Taiwan’s most serious recent natural disasters, the 921earthquake reflected the adaptability of institutions in the disaster relief process, from its early stage of initial confusion to the central government’s slow gaining of control over the operational orbit and seeking of cooperation with local governments and the private sector. However, at the same time, the fact that social forces could play an important role in the governance process, even obtaining a position of active participation in political decision-making and establishing public-private cooperation, is related to the failure of the central government command system to effectively empower local governments.
A Review on Public Health and Economic Significance of Brucellosis

Zoonotic diseases are of major concern worldwide. Brucellosis is considered to be one of the world’s most important causes of illnesses in animals and humans. Brucellosis is an infectious, contagious, double burden and worldwide spread zoonotic disease caused by bacteria of the genus Brucella that have a wide host ranges and this facilitates the spread of the disease in different domestic and wild animals including humans. It is a public health problem with adverse health implications both for animals and human beings as well as economic implications for individuals and communities. Management, animal movement, wide ranges of host, herd size, commingling of different animal species are risk factors for animal brucellosis. The possible risk factors for human brucellosis are feeding behavior, occupational exposure, contact with diseased animals or their products and discharges. Brucellosis is characterized by similar clinical signs in different animal species and recognized after the animals are sexually matured. In animals the common clinical signs of brucellosis are abortion, retained placenta, orchitis, epididymitis and arthritis. Infertility is a common sequel of animal brucellosis and this is one of the factors that bring negative impacts on the development of economy of the infected countries. Human brucellosis is characterized by a variable incubation period and clinical signs include symptoms of continued, intermittent or irregular fever of variable duration, with headaches, weakness, profuse sweating, chills, depression and weight loss. In humans undulating fever is the most frequently observed sign. Abortion is also happened during the early trimesters of pregnancy. The disease is known widely distributed in Ethiopia among animals and human. Hence, periodic research should be conducted in the country to evaluate the prevalence of the disease; implementation of well-organized disease control and prevention methods must be undertaken to mitigate its impacts. Keywords: Brucella, Brucellosis, Economic significance, Public Health
Genetic algorithms in forecasting of Internet shops demand

The general aim of this article is to present genetic algorithms as a tool, that can be used in de-mand forecasting in internet shops. First part of article identities factors, which have to be taken into consideration during analysing demand in internet shops, e.g. dispersion of demand, delivery time in-fluence and different e-marketing factors. Specific form of used demand function is shown in the next section of the article. Then genetic algorithm is defined by its genetic operators acting on bit strings (examples of the operators are: crossover, inversion, and mutation) and its method of credit allocation (fitness evaluation and selection). Next the method of identification of the function parameters using genetic algorithms is shown. The next part of article shows appliance of presented genetic algorithm. The advantages and disadvantages of proposed method are shortly discussed in summary.
How Mental Genes Make the Human Mental Complex and Control Its Functioning: Transition From The Genetic Mind to the Intelligent Mind

This paper aims to explore in detail the formation and functioning of the many-layered contemporary human mind by mental genes and the complex and elaborate problems the human mind has created both within and outside of itself due to the logic of its genetic formation. The existing mind of an individual is essentially an unconsciously formed gene-based mental complex whose formation and functioning is largely controlled and dominated by a two-way connection between his mental genes and mental processes. Due to this, the mental autonomy he experiences is more of an illusion than reality. There seem to be two main varieties of mental templates or mental genes in human beings and numerous specific sub-types within each variety. One, which contain the template for lower order mental functions (habits, temperament, basic emotional positions, motivations and agendas, and self-centered intelligence) which we share with animals and other living things. The other which do not contain the template for a specific function but only the template for a higher order mental capability (say of complex reasoning and intellectual processing, and developed sensitivities) unique to human beings and which is concretized through a highly developed and on-going learning process. The existing gene-based mind of man is an evolved product of the dynamic and interconnected functioning of all the varieties and sub-varieties of mental genes and brain processes, in a many-sided interaction with the environment. In addition, in our view our mental processes and their experiences have a communication process in place with our mental genes (at the nonverbal and unaware level) and the capability to modify them. In fact, this communication process is probably the mechanics of mental evolution in general, in living things. The primary motivation behind our inquiry is to incrementally replace the existing unintelligent mental software and programme in our mental genes, with an intelligent process/system (for the formation of mental processes) not controlled by the genes but by our advanced intellectual and emotional processes. It is this transition within an individual, which will enable him to intelligently cope with and find long-term solutions to his problems.
Cullin Ring Ubiquitin Ligases (CRLs) in Cancer: Responses to Ionizing Radiation (IR) Treatment

Treatment with ionizing radiation (IR) remains the cornerstone of therapy for multiple cancer types, including disseminated and aggressive diseases in the palliative setting. Radiotherapy efficacy could be improved in combination with drugs that regulate the ubiquitin-proteasome system (UPS), many of which are currently being tested in clinical trials. The UPS operates through the covalent attachment of ATP-activated ubiquitin molecules onto substrates following the transfer of ubiquitin from an E1, to an E2, and then to the substrate via an E3 enzyme. The specificity of ubiquitin ligation is dictated by E3 ligases, which select substrates to be ubiquitylated. Among the E3s, cullin ring ubiquitin ligases (CRLs) represent prototypical multi-subunit E3s, which use the cullin subunit as a central assembling scaffold. CRLs have crucial roles in controlling the cell cycle, hypoxia signaling, reactive oxygen species clearance and DNA repair; pivotal factors regulating the cancer and normal tissue response to IR. Here, we summarize the findings on the involvement of CRLs in the response of cancer cells to IR, and we discuss the therapeutic approaches to target the CRLs which could be exploited in the clinic.
Predictors of review sites usage in hotels Predictores del uso en hoteles de plataformas de valoración

The tourism industry has been strongly impacted by the consumer use of review sites. Since review travel sites such as TripAdvisor allowed accommodations to create own profiles with information, hotels began incorporating these actions into their engaging customers programming. Despite the benefits that review sites can offer to customers, hotels and accommodations, its implementation is not developed and exploited in all its possibilities, and little is known about hotels use of this review sites. This study explores the topic trough quantitative methodology, conducting multiple correlation analysis of data obtained from a sample of 301 hotel managers. Managers consider they are committed to this type of platforms and are capable of use it accurately. Also it was found evidence of correlation between use of TripAdvisor and hotel characteristics (size, ownership structure, and category). Furthermore, multiple regression analysis shows competence and commitment as the most important predictors of use intensity.
Titi Mbah ASSESSING MOTIVATION AS A TOOL TO ENHANCE EMPLOYEE PERFORMANCE

Kokkola-Pietasaari Unit Date December 2015 Author Titi Mbah Degree programme Degree program in Business Management Name of thesis ASSESSING MOTIVATION AS A TOOL TO ENHANCE EMPLOYEE PERFORMANCE Case; New Life Enterprise Instructor Brigitta Niemi Pages 32 + Appendixes Supervisor Brigitta Niemi One of the most important goals of every organisation is to have employees who are highly performing and are motivated to work at all time. Achieving this dream has been cumbersome because of dynamic and complex behaviour of workers. The subject matter of this thesis aims to analyse effective ways through which employees can be motivated so that high performance will be attained within the company. Therefore trained and skilful managers should handle such tasks. To have a deeper meaning of what employee motivation really is, five theories of motivation were taken into consideration. These theories include; Hierarchy of needs theory, Two factor theory, The carrot and stick theory, Reinforcement theory and Theory x and theory y. There was an analysis in the relationship between employee motivation and performance. Furthermore, the views of some managers in leading companies in the USA, Asia and Scandinavia on motivation were considered. In addition, this thesis also examined how cultural values and differences influence employee motivation based on Hofstede’s value typology. New Life Enterprise represents the case study where an empirical study was conducted. Questionnaires were designed and interviews conducted to get first hand data concerning the opinions of the employees and manager on how motivation is practised in New Life Enterprise. After an assessment of the theories in relation to the empirical study, the results obtained uncovered the fact that most elements of motivation were neglected by the management of New Life Enterprise which could have been in action to constantly stimulate employees. Recommendations were made which will enable the management of New Life Enterprise to adjust its motivation structure such that workers needs are effectively met thereby motivating these workers to put in their best.
ANN Control of Non-Linear and Unstable System and its Implementation on Inverted Pendulum

The inverted pendulum is a classical problem for control problem, therefore it is used to benchmark new control techniques This process is best suited for control engineers working on developing new controllers as it is highly nonlinear and unstable. The inability of normal controllers like PID to adapt to changes in the process forces our hand in developing controller with intelligence. Controllers with intelligence means the ability of the controller to react or adapt to uncertainty in the unknown process. Neural Network Controller has the ability to learn and also ability to tolerate incorrect or noisy data. Moreover developing a controller using Adaptive Linear Element (ADALINE) and Radial Basis Function based (RBF) based controllers doesn’t require mathematical modelling of the system. The main aim of the project is to keep the pendulum erect. The use of Neural Network based controller reduces the error. The Adaptive Neural Network toolbox is used to do a comparative study of the two types of controllers.
Measuring Polycentricity of Mega-City Regions in China Based on the Intercity Migration Flows

Abstract. This paper uses the intercity migration flows to examine relations between Chinese cities, identify the important mega-city regions and measure each region's polycentricity from an interaction perspective. Data set contains the long-term residential migration trajectories of three million Sina weibo users across 345 cities. Cities with close connectivity deployed around one or several mega cities are identified as mega-city regions. Features of the mega-city regions are characterized by the strength of migration flows, density of connections, and regional migration patterns. The results show that the disparities exist in different mega-city regions; most mega-city regions are lack of polycentricity.
Revisiting the structure of a synthetic somatostatin analogue for peptide drug design.

Natural or artificially manufactured peptides attract scientific interest worldwide owing to their wide array of pharmaceutical and biological activities. X-ray structural studies are used to provide a precise extraction of information, which can be used to enable a better understanding of the function and physicochemical characteristics of peptides. Although it is vulnerable to disassociation, one of the most vital human peptide hormones, somatostatin, plays a regulatory role in the endocrine system as well as in the release of numerous secondary hormones. This study reports the successful crystallization and complete structural model of octreotide, a stable octapeptide analogue of somatostatin. Common obstacles in crystallographic studies arising from the intrinsic difficulties of obtaining a suitable single-crystal specimen were efficiently overcome as polycrystalline material was employed for synchrotron and laboratory X-ray powder diffraction (XPD) measurements. Data collection and preliminary analysis led to the identification of unit-cell symmetry [orthorhombic, P212121, a = 18.5453 (15), b = 30.1766 (25), c = 39.798 (4) Å], a process which was later followed by complete structure characterization and refinement, underlying the efficacy of the suggested (XPD) approach.
On the Role of Glonass for the Development of the Russian Geodetic Reference Network

On the Role of Glonass for the Development of the Russian Geodetic Reference Network The combined use of GPS and GLONASS satellite systems is a main technology for the development of the fundamental geodetic network in Russia and for crust movement studies along the North Eurasian tectonic plate. All permanent stations of the state fundamental geodetic network will be provided with the two frequency GPS and GLONASS receivers. A collocation of these stations with the existing Russian sites of the international GNSS (Global Navigation Satellite System) network is foreseen. The GLONASS state program foresees to come to 18 satellites in constellation in 2007-2008, and full operation capability (24 satellites) will be reached by 2009. The second generation of satellites: GLONASS-M have the L2 civil signal, extended lifetime and improved clock stability. GLONASS-K satellites are expected by 2009 with the L3 civil signal and Synthetic Aperture Radar function. A combination of GPS and GLONASS will benefit the scientific geodynamic research and practical users, especially in the urban, mountain and near polar areas. Results of the experimental GLONASS data analysis performed. Comparison of mean values of coordinates from only GLONASS solution, obtained at the Institute of Astronomy (Moscow) with the use of GIPSY-OASIS2 software, with the mean values from the GPS PPP solution for the IGS sites showed that differences are mainly within a few cm, provided that incomplete configuration of GLONASS satellites have been observed.
Efecto de agregar agua sobre el punto crioscópico y componentes de la leche cruda de vacas Jersey y Holstein

Introducción: El punto crioscópico se usa para evaluar la calidad de la leche cruda entera y sus productos. Objetivo: Determinar el efecto de agregar agua sobre el punto crioscópico, composición bromatológica, contenido de urea, conteo de células somáticas y contenido de bacterias de la leche cruda. Métodos: Durante la primera etapa, tomamos 35 muestras de leche (80mL) de las localidades de Turrialba en Cartago y Zarcero, en Alajuela (abril y octubre del 2018). Agregamos agua (5, 10, 15, 20, 25 y 30% p/p) y una muestra sin adulterar como control (5 repeticiones de cada uno). Resultados: La adición de 5% de agua (p/p) fue suficiente para alterar todos los parámetros. En una segunda etapa, evaluamos concentraciones más bajas (1, 2, 3, 4 y 5% p/p). Conclusión: La adición de 1% p/p produce cambios significativos en tres parámetros: punto crioscópico, contenidos bromatológicos y conteo de células somáticas.
Preferential processing of visual trauma-film reminders predicts subsequent intrusive memories

This study used an analogue design to test the hypothesis that preferential processing of visual trauma reminders in the aftermath of a stressful or traumatic event gives rise to subsequent intrusive memories. Shortly after the presentation of a stressful film fragment, participants (n=36) were asked to detect neutral targets (rotated buildings or nature scenes) in a single target rapid serial visual presentation (RSVP) paradigm. During half of the streams, the target was preceded by a distracter. The distracters consisted of visual images extracted from an earlier presented stressful film (e.g., persons and objects that figured in the film). The degree of interference by these film reminders predicted subsequent intrusions recorded in a one-week diary. The results provide evidence that a deficient ability to obtain attentional control over perceptual “trauma” reminders during goal-directed behaviour may set people at risk for persistent intrusive memories. Implications for research investigating attentional bias and intrusive memories in context of posttraumatic stress disorder (PTSD) are discussed.