Miracle-dz/UniFAR-FTUs huggingface dataset:
Itraconazole-Enhanced Chemotherapy Toxicity in a Patient With Hodgkin Lymphoma

The authors describe the clinical course of a boy with Hodgkin lymphoma who developed severe myelosuppression and neurotoxicity after the concurrent administration of vinblastine, doxorubicin, methotrexate, and prednisone chemotherapy (VAMP) and itraconazole. Several case reports have identified itraconazole-enhanced chemotherapy toxicity, especially in association with vinca alkaloid chemotherapy. This patient showed similar exacerbation of chemotherapy toxicity related to concurrent administration of itraconazole and vinblastine, doxorubicin, and methotrexate. Inpatient supportive management along with withdrawal of offending drugs resulted in the resolution of myelotoxic and neurotoxic manifestations. Hepatic cytochrome P450 enzyme inhibition and P-glycoprotein pump inhibitors are believed to interfere with the metabolism of several anticancer agents. Appropriate care should be exercised when combining cancer chemotherapy with cytochrome P450 and P-glycoprotein inhibitors, such as itraconazole.
The bcr1 DNA Repeat Element Is Specific to the Bacillus cereus Group and Exhibits Mobile Element Characteristics

ABSTRACT Bacillus cereus strains ATCC 10987 and ATCC 14579 harbor a ∼155-bp repeated element, bcr1, which is conserved in B. cereus, B. anthracis, B. thuringiensis, and B. mycoides but not in B. subtilis and B. licheniformis. In this study, we show by Southern blot hybridizations that bcr1 is present in all 54 B. cereus group strains tested but absent in 11 Bacillus strains outside the group, suggesting that bcr1 may be specific and ubiquitous to the B. cereus group. By comparative analysis of the complete genome sequences of B. cereus ATCC 10987, B. cereus ATCC 14579, and B. anthracis Ames, we show that bcr1 is exclusively present in the chromosome but absent from large plasmids carried by these strains and that the numbers of full-length bcr1 repeats for these strains are 79, 54, and 12, respectively. Numerous copies of partial bcr1 elements are also present in the three genomes (91, 128, and 53, respectively). Furthermore, the genomic localization of bcr1 is not conserved between strains with respect to chromosomal position or organization of gene neighbors, as only six full-length bcr1 loci are common to at least two of the three strains. However, the intergenic sequence surrounding a specific bcr1 repeat in one of the three strains is generally strongly conserved in the other two, even in loci where bcr1 is found exclusively in one strain. This finding indicates that bcr1 either has evolved by differential deletion from a very high number of repeats in a common ancestor to the B. cereus group or is moving around the chromosome. The identification of bcr1 repeats interrupting genes in B. cereus ATCC 10987 and ATCC 14579 and the presence of a flanking TTTAT motif in each end show that bcr1 exhibits features characteristic of a mobile element.
Th2‐type cytokines, hypereosinophilia, and interleukin‐5 in HIV disease

I (IL)-5 is a T-cell-, mast-cell-, and eosinophil-derived cytokine with selective effect on cells of the eosinophil lineage (1). Its role is debatable in experimental models of bronchial hyperresponsiveness, where it is linked to induction of IgE responses in mice, as well as in human asthma (2). Some recent reports could not be included in the review published in Allergy (1996) (3), and their results should be considered in view of studies on other conditions involving hypereosinophilia. Indeed, the original paper (4) describing Th2-type cells as inducers of The hypereosinophilia
In response to "Brimful of STARLITE".

I appreciate Andrew Booth's effort to promote standards for reporting the findings of systematic reviews of qualitative research [1]. Yet, several of our papers were erroneously considered in Booth's work. These papers (references 61, 83, and 84 in the Booth paper) were not formal metasyntheses and were focused on methods for such reviews, rather than results. These papers were misrepresented in the STARLITE analysis as they were not reports of studies but rather methodological papers on how to do them, as indicated in each of these papers. Booth also overlooks a key issue facing authors of such reviews: editors and publishers decide what to include in such reports and have their own standards for tailoring reports to their audiences. For example, we have been told not to include lists of papers or details of search terms, databases, and related material to conserve space. Authors are then compelled to limit the information provided in reports and make this additional detail available on request. In addition, it may be seen as duplicate publication to repeat details of a search when two or more synthesis reports are written from the same data set. Booth and others interested in such issues may wish to read two publications that address them further [2, 3].
A new vision for wound healing.

While there can be no questioning the passion and enthusiasm of the people engaged in delivering and researching tissue viability, few of them could honestly claim that it is a hugely dynamic field of clinical practice. So it is rare for me to read an article that offers the possibility of a significant shift in our whole approach to wound healing. The paper by Wolcott and Rhoads in this issue is one of these.
Helicobacter pylori toxin VacA induces vacuole formation by acting in the cell cytosol

Cells exposed to Helicobacter pylori toxin VacA develop large vacuoles that originate from massive swelling of membranous compartments of late stages of the endocytic pathway. To determine if the toxin is active from the cell cytosol, cells were either microinjected with toxin or transfected with plasmids encoding VacA. Both procedures cause formation of intracellular vacuoles. Cytosolic localization of the toxin was assessed by indirect immunofluorescence with specific antibodies and by expression of an active green fluorescence protein (GFP)–VacA chimera. Vacuoles induced by internally produced VacA are morphologically and functionally identical to those induced by externally added toxin. It is concluded that VacA is a toxin acting intracellularly by altering a cytosol‐exposed target, possibly involved in the control of membrane trafficking.
Early feeding for lifetime performance of pigs

Correct feeding and management of the young pig for optimum lifetime performance is a key goal of pig producers, although the associations between these variables are often difficult to quantify. It is well recognised that commercial growth rates of suckling and weaned pigs are less than those that can be achieved when pigs are reared independently of the sow and/or fed greater quantities of a more nutritious source of nutrients such as bovine milk. However, such management interventions for attaining greater postnatal growth rates are not commonplace in the pig industry; the most common form of supplementary feeding of young pigs is creep/starter feed. A frequent question asked by producers and the feed manufacturing industry is whether pigs that achieve a ‘good start’ during the weaning period extend the growth advantage through to slaughter. Data presented in this paper suggest that the weight of the pig at birth explains a substantial proportion of the variation in postnatal growth. An array of different dietary and management interventions has been used to manipulate weaning weight and growth rate after weaning with the aim of maintaining a weight advantage through to slaughter. However, in many cases, the ‘control’ pigs appear to compensate and there are no differences in performance and carcass indices at slaughter. Despite this, recent data from experiments conducted in Western Australia show that processes occurring before and after weaning could influence carcass weight and dressing percentage of pigs that weigh more than 105 kg at slaughter. In particular, the effects of the rearing environment during suckling, the type of creep diet fed during suckling and the housing system after weaning appeared to influence carcass weights and dressing percentages.
In vivo small-animal imaging using micro-CT and digital subtraction angiography

Small-animal imaging has a critical role in phenotyping, drug discovery and in providing a basic understanding of mechanisms of disease. Translating imaging methods from humans to small animals is not an easy task. The purpose of this work is to review in vivo x-ray based small-animal imaging, with a focus on in vivo micro-computed tomography (micro-CT) and digital subtraction angiography (DSA). We present the principles, technologies, image quality parameters and types of applications. We show that both methods can be used not only to provide morphological, but also functional information, such as cardiac function estimation or perfusion. Compared to other modalities, x-ray based imaging is usually regarded as being able to provide higher throughput at lower cost and adequate resolution. The limitations are usually associated with the relatively poor contrast mechanisms and potential radiation damage due to ionizing radiation, although the use of contrast agents and careful design of studies can address these limitations. We hope that the information will effectively address how x-ray based imaging can be exploited for successful in vivo preclinical imaging.
Members of the low‐density lipoprotein receptor‐related proteins provide a differential molecular signature between parental and CD133(+) DAOY medulloblastoma cells

Members of the low‐density lipoprotein receptor‐related protein (LRP) family are involved in metabolic stress and resistance phenotypes of cancer cells. New breakthroughs in brain cancer therapy have exploited that molecular signature and proved that efficient delivery of therapeutic agents involve LRP‐mediated mechanisms. We performed gene expression profiling of CD133, a cell surface cancer stem cell marker, and of LRP in response to in vitro nutrient deprivation. We found that CD133 was selectively induced in serum‐starved DAOY medulloblastoma cells but not in U87MG glioblastoma cells. Such CD133 induction was correlated to increases in LRP‐1 and LRP‐1b gene and protein expression. When a specific CD133(+) DAOY cell population was sorted from parental DAOY, we found increases in LRP‐5 and LRP‐8. Uptake of α2‐macroglobulin, a specific LRP‐1/1b ligand, was increased in serum‐starved parental DAOY cells but not in CD133(+) DAOY cells, and receptor‐associated protein (RAP), which binds to all cell surface LRPs, was able to compete for that uptake. Conversely, RAP binding was increased in serum‐starved parental DAOY but α2‐macroglobulin was unable to compete for such uptake. Strategies aiming at targeting cancer stem cell metabolic adaptative responses, such as that through LRP differential expression within the brain tissue microenvironmental niche, can now be envisioned. © 2010 Wiley‐Liss, Inc.
Pericranial Muscle Tenderness and Exteroceptive Suppression of Temporalis Muscle Activity: A Blind Study of Chronic Tension‐Type Headache

The aim of the present study was to examine the ability of pericranial muscle tenderness and the second exteroceptive suppression period to distinguish chronic tension‐type headache sufferers, migraine sufferers, and controls in a young adult population utilizing a blind design. The second exteroceptive suppression periods were assessed using the methodology recommended by the European Headache Federation and were scored with an automatec computer software program designed in our laboratory to provide reliable, standardized, and precise quantification of exteroceptive suppression periods and eliminate any influence of experimenter bias that may occur with manual scoring.
Determining surface potentials from current dipoles, with application to electrocardiography.

This paper presents a method for determining the potentials over the surface of a three-dimensional volume due to internal current sources. The volume may be inhomogeneous and irregularly shaped. The method for determining the potentials uses N simultaneous equations which when solved produce the potentials at N different surface points. The N simultaneous equations are solved by an iterative technique on an IBM computer.
Pheromone receptors in mammals

In most mammals, pheromone perception mediates intraspecies interactions related to reproduction, such as mate recognition, intermale aggressive behaviors, or exchanges between females and their offspring. Recent molecular findings, particularly the identification of two large pheromone receptor gene superfamilies, provide today invaluable tools to better understand the way mammals make sense of pheromonal information.
CMOS-integrated poly-SiGe cantilevers with read/write system for probe storage device

A poly-SiGe technology enabling a dense array of micro-cantilevers and tips on CMOS is demonstrated. Built from a dual-thickness structural layer, the cantilevers feature a very small initial bending and have a compliant torsional suspension with a stiffness of 3×10−10 Nm/rad. Sharp tips are formed in a low-temperature amorphous silicon layer by isotropic plasma etching. An electrical read/write system is formed by connecting the tip to the CMOS with a suspended platinum trace, running on top of the cantilever.
Mormyromast electroreceptor organs and their afferent fibers in mormyrid fish: I. Morphology

Mormyromast electroreceptor organs are the most numerous type of electroreceptor organs in mormyrid electric fish and provide the sensory information necessary for active electrolocation. Mormyromast organs and their primary afferent fibers have not been studied very extensively. Both morphological and physiological questions remain to be answered before the neural basis of active electrolocation in mormyrids can be understood. This paper examines four different aspects of the morphology of mormyromast organs and afferent fibers: (1) Mormyromast organs in the skin. The innervation patterns for the two types of separately innervated sensory cells in the mormyromast organ are described on the basis of silver‐stained whole mounts of skin. The number of sensory cells per mormyromast organ increases linearly with fish growth for both types of sensory cells. (2) Relation between peripheral sensory cell innervated and central zone of termination for mormyromast afferent fibers. The afferent fibers arising from the two types of sensory cell in the mormyromast organ project to separate zones of the electrosensory lateral line lobe, as shown by using retrograde labeling with horseradish peroxidase. (3) Central trajectories and terminal arbors of mormyromast afferent fibers. These aspects of mormyromast fibers are described by using intracellular staining of individual fibers as well as whole nerve staining of an electrosensory nerve. (4) Fine structure of mormyromast afferent terminals in the electrosensory lateral line lobe. Afferent fibers make various synaptic contacts, including contacts of a mixed type, gap junction‐chemical, onto a restricted class of granule cells. The fine structure is described based on electron microscopy of horseradish‐peroxidase‐labeled fibers.
A simple parallel-plate wave launcher in substrate integrated waveguide technology

We present a compact substrate integrated waveguide (SIW) fed, parallel-plate wave launcher which is able to excite a TEM wave in a dielectric-filled parallel-plate waveguide (PPW). The engineered wave-front with controlled amplitude and phase distribution, can generate a desired aperture for conventional antenna structures and other integrated feed systems. For example, our proposed PPW launcher may be useful when feeding planar, parallel-plate slot-array antennas in PCB technology. In this work theoretical design curves are initially presented for such PPW launchers. Results are then confirmed by full-wave simulations of two SIW-fed, PPW designs operating at 15 GHz, and covering two different aperture widths of 5 cm and 10 cm. Our novel approach for simple, PPW launching at microwave and millimeter-wave frequencies can also be applied to other parallel-plate based guides, low-cost transitions, and compact dividing/combing circuits for new antenna feed systems.
Adenovirus vector technology: An efficient method for constructing recombinant adenovirus and on/off switching of gene expression

An efficient method of constructing recombinant adenoviruses (Ad) has been established. The expression unit to be introduced into recombinant Ad was first inserted into the unique SwaI site of the full‐length Ad genome cloned in a cassette cosmid. The cassette bearing the expression unit was then cotransfected to 293 cells together with the Ad DNA‐terminal protein complex digested at several sites with EcoT22I. The use of the parent Ad DNA‐terminal protein complex instead of the deproteinized Ad genome DNA allowed very efficient recovery of the desired recombinant Ad, and the restriction digestion drastically reduced regeneration of the parent virus. This method may facilitate the application of recombinant Ad and should be useful for further improvement of Ad vectors. Also a recombinant adenovirus expressing Cre recombinase derived from bacteriophage P1 was constructed. To assay the Cre activity in mammalian cells, another recombinant Ad bearing an on/off switching reporter unit, where a LacZ‐expression unit can be activated by the Cre‐mediated excisional deletion of an interposed stuffer DNA, was also constructed. Co‐infection experiments together with the Cre‐expressing and the reporter recombinant Ad showed that the Cre‐mediated switching of gene expression was detected in nearly 100% of cultured CV1 cells. These results suggest that the recombinant Ad efficiently expressed functional Cre and offers a basis for establishing a powerful on/off switching strategy of gene expression in cultured mammalian cells and presumably in future gene therapy.
CoWoOZ — A cloud-based teleoperation platform for social robotics

This paper presents our cloud-based teleoperation platform, called CoWoOZ — ClOud-based Wizard of OZ. It describes similar systems, such as Robot Management System (RMS), OpenWoZ, CoWoOZ's predecessor Telescope and the first version of the discussed platform. A special emphasis is given to the description of new functionalities added to the system, e.g. scenario management, custom script builder, client application, etc. The paper also contains a comparison of these systems, which can help researchers to choose the right one for their work.
Computation of radar cross section of waveguide arrays

A review of the open literature shows that not much information has been published on the radar cross-section (RCS) of waveguide arrays. An accurate method for the computation of the RCS of active waveguide arrays is presented. It combines the plane wave angular spectrum method used by Stalzer et al. (1978) to find the active element radiation pattern of an infinite phased array and the generalized scattering matrix (GSM) approach to periodic waveguide array analysis. The active scatter pattern of an element in an infinite array is obtained in terms of the reflection coefficients of the free space Floquet modes found by the GSM procedure. This active scatter pattern is employed in the computation of the RCS of a finite array by assuming that it is identical for all elements of the array and ignoring the edge effects in the process. The accuracy of this model has been validated by the good agreement observed between predictions and published test results of arrays of various sizes.
[The point about...uremia and cancer].

There have been long-lasting controversies as to whether uremic patients are prone to develop cancer. Recent epidemiological data support a small, but significant increase of various solid tumors, particularly those known to be induced by viruses. Paradoxically, either younger or female patients are the most exposed to the risk of cancer. In addition to factors linked to the underlying renal disease (e.g. analgesic abuse, "chinese herbs" or immunosuppressive drugs), uremia per se can enhance carcinogenesis through many different pathways: retention of various carcinogens; abnormalities of nucleic acids; decreased immune response; metabolic and nutritional changes (hyperhomocysteinemia, iron or selenium depletion.); deleterious effects of oxidative stress secondary to bioincompatibility reactions during dialysis. However, except for the ultrasonographic diagnosis of cystderived renal carcinoma, which has been shown beneficial in the younger patients, there should be no routine cancer screening peculiar to uremic patients.
Visual vigilance performance and standing posture at sea.

BACKGROUND Research on land has demonstrated interactions between visual tasks and the control of stance. Variations in visual tasks can influence postural activity; conversely, changes in stance can influence quantitative measures of visual performance. At sea, crewmembers may alter their bodily movements to compensate for ship motion while simultaneously adjusting movements to optimize visual performance. Mutual influence of visual tasks on postural movements and of postural movements on visual tasks has not been demonstrated at sea. METHODS Crewmembers stood on a force plate, from which we obtained data on the positional variability of the center of pressure (COP). We varied stance width (5 cm, 17 cm, and 30 cm) and the difficulty of visual vigilance tasks (Easy vs. Hard). We collected data on visual performance and we assessed subjective mental workload. RESULTS Visual performance was better on the Easy task (mean d' = 4.28) than on the Hard task (mean d' = 3.55). Consistent with this result, subjective mental workload was greater for the Hard task than for the Easy task. The variability of postural activity was greater during the Easy task (mean = 2.0 cm x s(-1)) than during the Hard task (mean = 1.9 cm x s(-1)). Stance width influenced postural activity, but also (in 2-way and 3-way interactions) influenced visual performance. Both the magnitude and dynamics of postural activity changed over days at sea. CONCLUSIONS In mild seas, variations in stance width modulate standing posture and influence the performance of computer-based visual tasks.
Confiance dans les associations et positionnement dans le débat public sur les OGM

L'apparition des plantes Genetiquement Modifiees, en Europe, a donne lieu a des debats importants. Issue de ce debat, la reglementation actuelle concernant les OGM apparait comme le resultat d'une dynamique contradictoire entre les differents interets d'acteurs (mouvement associatif, lobby industriel, expert et scientifique, representants politiques) organises en groupes de pression, s'appuyant chacun sur differents registres de justification des bienfaits ou des inconvenients supposes des biotechnologies agricoles. Les donnees de l'Eurobarometre 58.0 permettent de preciser l'importance de la confiance dans les associations pour le positionnement dans le debat public de la part des "citoyens ordinaires" (Joly, Marris 2003). En conclusion, sont discutes les principaux faits stylises ainsi caracterises.