Miracle-dz/UniFAR-FTUs huggingface dataset:
2,6-Dimethyl-4-(1,3,4-oxadiazol-2-yl)quinoline

The title compound, C13H11N3O, a potential chemotherapeutic agent, contains a essential planar [maximum deviation = 0.0144 (14) Å] quinoline moiety. The quinoline ring system and the five-membered heterocycle form a dihedral angle of 7.81 (6)°. In the crystal, intermolecular non-classical C—H⋯N hydrogen bonding is present.
Tetra-μ3-methano­lato-tetrakis­[(2-formyl­phenolato-O)(methanol-O)­cobalt(II)]

The title complex, [Co4(CH3O)4L4(CH4O)4] (LH = 2-hydroxy­benz­aldehyde, C7H6O2), has a cubane-type structural topology with four Co atoms and four O atoms, each derived from MeO−, at alternate corners. Each Co atom is coordinated in a distorted octahedral geometry defined by three bridging O atoms, two O atoms from chelating L, and one O atom from a methanol mol­ecule.
Factors affecting outcome after primary intracerebral hemorrhage

Primary intracerebral hemorrhage (ICH) accounts for 10–15% of all strokes. ICH is the most devastating subtype of stroke with high mortality and morbidity; 35–52% of patients die during the first month after the bleeding. The most important risk factor for onset of ICH is hypertension, especially untreated hypertension, and the well-known predictors for early death after ICH are a low GCS (i.e low level of consciousness) score on admission, the size of the hematoma, and the precence of intraventricular blood. Preceeding use of anticoagulants and advanced age further impair the outcome. Thromboembolic complications after the bleed are common and difficult to prevent. The present cohort study included all patients (n = 453) with verified primary ICH admitted to the stroke unit of Oulu University Hospital within a period of 11 years (from January 1993 to January 2004). The impacts of previous diseases, including ischemic heart disease, atrial fibrillation on admission, hypertension, and diabetes as well as of high admission blood pressure and plasma glucose levels on outcome were evaluated. The safety and efficacy of prevention of venous thromboembolism with enoxaparin, a low molecular weight heparin (LMWH), was investigated. In a population-based study covering a 3-year period, the risk factors and seasonal distribution of ICH were investigated. Independent of the severity of bleeding and patients’ age, ischemic heart disease, diabetes, and atrial fibrillation were found to be significant predictors for early death after ICH. High blood pressure on admission predicted early death, whereas elevated admission plasma glucose level was associated with the severity of bleeding but was not an independent predictor for early death. Treatment with enoxaparin (20 mg per day subcutaneously) for prevention of venous thromboembolism was not associated with increased mortality but did not seem to prevent venous thromboembolic complications. The incidence of ICH was higher during the winter among patients with untreated hypertension but not in normotensive and treated hypertensive patients.
Chinese Topic Link Detection Based on Semantic Domain Language Model

Topic link detection is a foundational research in the field of topic detection and tracking, which detects whether two random stories talk about the same topic. This paper proposes a method of applying semantic domain language model to link detection, based on the structure relation among contents and the semantic distribution in a story, and also verifies the influence of the strategy incorporating dependency parsing into semantic description. Evaluation on Chinese Corpus of TDT4 show that the semantic domain language model substantially improved the performance of current detection system, whose minimum DET cost is reduced by about 3 percent.
Multiple Non-rigid Objects Tracking by Modified Kernel Particle Filter

This paper proposed a new method for multi-target tracking in video sequences by combining two trackers, sum-of-squared differences (SSD) and kernel particle filter (KPF). In our work, the idea of Object Likelihood Value of pixel is proposed. Instead of using direct propagation resample result from the previous sample set, a weighted SSD displacement is used for reinitializing and resample before next KPF iteration. Experiment results on soccer athletes tracking show that the combination of SSD with KPF tracker forms a simple and powerful multiple non-rigid object tracking system.
99mTc-Methylene Diphosphonate Bone Scintigraphy in a Young Woman with Femoral Head Osteonecrosis after Core Decompression: A Case Report and Review of the Literature

Avascular necrosis may occur in several bones, especially at the femoral head. The exact etiology is still unknown. Major trauma and non-traumatic factors play important roles. Early detection is the most crucial factor of disease progression. Radiography, bone scintigraphy, and MR images are available for detection of early bone collapse. MR images and bone SPECT are highly sensitive tools. We report a young female who suffered left groin pain for months. Core decompression procedure with bone graft was performed under the diagnosis of idiopathic femoral head osteonecrosis, Ficat stage liB. Bone scintigraphy after surgery revealed linear inc reased tracer at the femora l neck and intertrochanteric region, precisely the area where the core decompression procedure was performed. We suggest that the viability of a bone graft can be evaluated by bone scintigraphy.
2-(6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-ylidene)propanedinitrile

The molecular conformation of the title compound, C15H10ClN3, is stabilized by an intramolecular N—H⋯N hydrogen bond with an S(7) ring motif. The crystal packing is controlled by N—H⋯N and C—H⋯N intermolecular interactions. One of the methylene groups of the cyclohexene ring is disordered over two positions with refined occupancies of 0.457 (12) and 0.543 (12).
Study of conjunctival impression cytology in assessing goblet cell density in dry eyes

Background: Dry eye is a chronic multi-factorial condition characterized by disturbances in the tear film and ocular surface with a decrease in goblet cells which can be assessed by conjunctival impression cytology (CIC) which is as effective as biopsy for diagnostic purposes. It helps establish not only the diagnosis of dry eye but also aids in grading the severity. This is a highly sensitive method to detect pathological changes in the conjunctival surface and confirm the clinical diagnosis. The aim of the study was to determine the goblet cell density by impression cytology, grading the severity of dry eyes and comparing the study with other studies. Methods: Study was conducted for a period of 2 yrs from August 2011 to July 2013 in 80 patients above 20 yrs age with clinically established diagnosis of dry eye who were subjected to conjunctival imprint cytology and stained with PAS to estimate he goblet cell density. Results: Out of the 80 cases of dry eye studied 45 were females and 35 were males with a female to male ratio of 1.28: 1 with a slight female preponderance. Age of the patients ranged from 21yrso 73 yrs. CIC showed positivity in 43 cases (53.75%) and negative in 37 cases (46.25%). 39 cases (90.70%) of positive CIC were above the age of 40 years. Conclusions: Dry eyes were found to be more common in age group above 40yrs with slight female preponderance. CIC showed decreased goblet cell density with increasing age in clinically diagnosed dry eyes.
8-Chloromethyl-5-(2,5-dioxooxolan-3-yl)-3,3a,4,5-tetrahydro-1H-naphtho[1,2-c]furan-1,3-dione

The title compound, C17H13ClO6, is an asymmetric alicyclic dianhydride containing a chloromethyl-substituted tetrahydronaphthalene moiety. The cyclohexene ring in the tetrahydronaphthalene moiety exhibits an envelope conformation with the tertiary C atom as the flap The dihedral angle between the two anhydride rings is 79.96 (6)°, while those between the benzene ring and the non-fused and fused anhydride rings are 71.03 (5) and 42.57 (7)°, respectively. In the crystal, molecules are connected by weak C—H⋯O interactions, forming a three-dimensional supramolecular structure.
3H-Furo[3,4-c]isochromene-1,5-dione

Isocoumarin is an abundant structural motif in natural products (Barry, 1964). Many constituents of the steadily growing class of known isocoumarins exhibit valuable biological properties, such as antifungal (Meepagala et al., 2002), antitumor or cytotoxic, anti-inflammatory, anti-allergic (Rossi et al., 2003), and enzyme inhibitory activities (Powers et al., 2002). Naturally occurring haloisocoumarins and their halo3,4-dihydroisocoumarin derivatives are very rare; however, a few examples of naturally occurring chlorine-containing isocoumarins are known (Larsen & Breinholt, 1999). In view of the importance of this class of compounds, the title compound, (I), has been synthesized, and its crystal structure is reported here.
2-Chloro-3-[(2-oxo-2H-chromen-6-yl)amino]naphthalene-1,4-dione

In the title compound, C19H10ClNO4, the dihedral angle between the naphthoquinone and coumarin rings is 48.99 (6)°. In the crystal, molecules are linked by strong N—H⋯O hydrogen bonds into chains with graph-set motif C(6) along [101]. The packing also features π–π stacking interactions between naphthoquinone and coumarin rings [centroid-to-centroid distances = 3.7679 (12) and 3.6180 (13) Å].
2-Chloro-N-[4-(3-methyl-3-phenylcyclobutyl)-1,3-thiazol-2-yl]-N′-(naphthalen-1-ylmethylidene)acetohydrazide

In the molecular structure of the title hydrazide derivative, C27H24ClN3OS, the acetohydrazide group is approximately planar, with a maximum deviation of 0.017 (3) Å. The dihedral angle between the naphthylene system and the phenyl ring is 78.91 (18)°. The crystal structure is stabilized by one weak intermolecular C—H⋯O hydrogen bond and two aliphatic C—H⋯π hydrogen-bonding associations.
(E)-1-Ferrocenyl-3-(2-methoxyphenyl)prop-2-en-1-one

The structure of the title compound, [Fe(C5H5)(C15H13O2)], consists of a ferrocenyl moiety and a 2-methoxyphenyl group linked through a prop-2-en-1-one spacer in an E conformation. In the ferrocene unit, the substituted cyclopentadienyl (Cps) ring and the unsubstituted cyclopentadienyl ring (Cp) are almost parallel to one another [dihedral angle = 1.78 (14)°], and the Cp and Cps rings are in a gauche conformation. The benzene ring is twisted by 10.02 (14) and 11.38 (11)° with respect to the Cp and Cps rings, respectively. In the crystal, molecules are linked by weak C—H⋯O hydrogen bonds into supramolecular chains running along the b-axis direction.
Obesity and kidney disease.

The rise in the prevalence of chronic kidney disease (CKD) and an increase in the prevalence of obesity in parallel in the recent years is a great concern. CKD increases the rate of cardiovascular disease (CVD) and development of end-stage renal disease, and leads to premature death. Although no direct causality link between obesity and CKD can yet be established, this appears highly probable. CKD should be regarded as a major complication of overweight and obesity, regardless of whether the association was independent or through the influence of diabetes, hypertension, CVD and metabolic syndrome. We review the literature on the complex but positive association between obesity and CKD, the pathological effect of excess adiposity in kidney injury and the potential role of weight reduction therapy in reducing the CKD.
(5S,6R)-5-Methyl-6-phenyl-4-propyl-1,3,4-oxadiazinane-2-thione

The title molecule, C13H18N2OS, is an oxadiazinanthione derived from (1R,2S)-norephedrine. There are two molecules in the asymmetric. Both adopt roughly half-chair conformations; however, the 5-position carbon orients out of opposite faces of the oxadiazinanthiones plane in the two molecules. In the crystal structure, they are oriented as a dimer linked by a pair of N—H⋯S hydrogen bonds. The absolute configuration has been established from anomalous dispersion and confirms the known stereochemistry based on the synthetic procedure.
5-Chloroacetyl-4-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

In the title compound, C12H13ClN2O2, the benzodiazepine ring adopts a distorted boat conformation. The carbonyl O atom and the Cl atom of the chloroacetyl group are in a cis conformation. The crystal packing is controlled by intermolecular C—H⋯O and N—H⋯O interactions.
10-Phenyl-6b,7,8,9,9a,10-hexahydro-6H-cyclopenta[4,5]pyrano[3,2-c]chromen-6,9-dione

In the title compound, C21H16O4, the dihedral angle between the phenyl ring and the 2H-chromene ring system is 59.8 (2)°. The crystal packing is stabilized by weak π–π stacking interactions [centroid–centroid distances = 3.667 (2) Å] and intermolecular C—H⋯O hydrogen-bonding interactions.
Experimental study of acute pancreatitis in a porcine model, especially tight junction structure and portal vein cytokines

Acute pancreatitis is a common disease, Finland being among the countries with the highest incidence. The majority of patients have a mild, self-limiting disease. However, 20% of these patients develop severe necrotizing pancreatitis with a mortality rate of 7 to 25%. The mechanisms for developing the severe disease are not known, it is not possible to accurately forecast the severity of the disease and there is no curative treatment yet. This study was aimed at analyzing the early phase of acute experimental porcine oedematous and necrotizing pancreatitis. In Study I, the pancreatic microcirculatory changes were measured and the expression of tight junction proteins (claudins-2, -3, -4, -5 and -7) and the rate of apoptosis in the pancreas were all measured. In Study II, bacterial translocation to the blood in the portal vein blood or to the mesenteric lymph nodes was analyzed and the intestinal expression of tight junction proteins (claudins-2, -3, -4, -5 and -7) and the intestinal apoptosis/ proliferation rates were measured. The basic histology of the jejunum and colon were analyzed. Study III analyzed which cytokines are released from the pancreas to the portal venous blood. In Study IV, the ultrastructure of the epithelium of the jejunum and colon was analyzed and the expression of adherens junction proteins, E-cadherin and β-catenin, were measured from both jejunum and colon. The first study (I) showed that membranous immunoreactivity of claudin-2 in acinar cells appeared in the pancreas during acute oedematous and necrotizing pancreatitis. The expressions of claudins -3, 4, 5 and 7 were unaffected. The second study (II) showed that bacterial translocation from the gut was not present at the beginning of acute porcine pancreatitis. The expressions of claudins-2 and -5 do not become altered; however, there might be some decrease in claudin-3 expression in the colon and decrease in the expression of claudins-4 and -7 in the jejunum in necrotizing pancreatitis. Performing the laparotomy itself caused increased apoptosis in the colon and the jejunum. In the third study (III), the initial inflammatory process was diverse in oedematous and necrotizing pancreatitis. Increased monocyte count in combination with elevated PDGF and IL-6 are characteristic of necrotizing pancreatitis in our model. The fourth study (IV) indicated that necrotizing pancreatitis caused damage to the epithelial and endothelial cells of the colon in the early stages of the disease. The expression of E-cadherin immunoreactivity showed a decreasing trend in the colon in both oedematous and necrotizing pancreatitis. The results of this study suggest that claudin-2 increases in acinar cells during acute porcine pancreatitis. Bacterial translocation is not present during the early phase of acute porcine pancreatitis. Increased monocyte count and elevated PDGF and IL-6 are characteristic of early phase necrotizing porcine pancreatitis and necrotizing porcine pancreatitis causes damage to the epithelial and endothelial cells of the colon.
Microbiological Profile of Brain Abscess

Objective: The objective of the study was to review the microorganisms found in the brain abscess. Methods We evaluated 104 patients of brain abscess admitted at our university hospital. Apart from routine hematological investigations and chest X-ray, all patients were subjected to CT scan or MRI study. Skiagram Skull, CSF study, Ultrasonography of head through open fontanelle in infants and in patients with cranial defects and special tests for Tuberculosis, HIV were done accordingly. Microbiological evaluation of the isolate was done in all cases. Preoperative and postoperative neurological function was assessed. Observations Pus culture was positive in 54.56 percent of cases. Anaerobic organism was found in 5.77 percent while mycobacterium in 3.85 percent, fungi in 1.92 percent. Streptococcus was the commonest offending organism followed by Staphylococcus and Pseudomonas. Pseudomonas was most resistant organism. Conclusion Chronic suppurative otitis media is still a major cause of brain abscess in developing country like India, which is a benign and curable disease and should not be neglected. Streptococcus was the commonest offending organism see. Unless anaerobic cultures are done, anaerobic organisms as causative agents can be easily missed. With the advent of newer and exotic diseases the culture spectrum of brain abscess is bound to change.
ELUCIDATING MECHANISMS THAT LEAD TO PERSISTENT ANXIETY-LIKE BEHAVIOR IN RATS FOLLOWING REPEATED ACTIVATION OF CORTICOTROPIN-RELEASING FACTOR RECEPTORS IN THE BASOLATERAL AMYGDALA

All Rights Reserved iv ACKNOWLEDGEMENTS First, I would like to thank my family and friends for their support and patience. Above all, I would like to thank my husband Ron who supported me throughout this whole process and was a continual source of encouragement on many different levels. Without his support I would not have been able to complete my studies. Next, I would like to thank Dr. Anantha Shekhar for his help and guidance throughout my graduate career. I am further grateful for the financial support and opportunity that presented itself under his tutelage. I would also like to thank the other members of my research committee, constructive criticism. Specific thanks to Bill for his time and efforts in teaching me molecular techniques, how to structure presentations and how to write. I would also like to thank Dr. Harris for advocating on my behalf. I have great respect for Dr. Harris and his support meant a lot. I emphatically believe that it takes innumerable advisors as well as administrative support to guide a graduate student towards the completion of his/her academic endeavors. I appreciate all help given by many. I would like to specifically thank Younglim Lee, Ph. their efforts that directly contributed to my training and data collection and to v fellow graduate student John Spence for his camaraderie and advice during the completion of this dissertation. I am also grateful for the personal awards and grants that provided financial support over the course of my studies for traveling expenses (Hingtgen Award and IUSM grant) and salary support (Scottish Rite Fellowship and the Department of Psychiatry). vi ABSTRACT Denise Gaskins Anxiety disorders are estimated to impact 1 in 4 individuals within their lifetime. For some individuals, repeated episodes of the stress response leads to pathological anxiety and depression. The stress response is linked to increased levels of corticotropin-releasing factor (CRF) in the basolateral nucleus of the amygdala (BLA), a putative site for regulating anxiety and associative processes related to aversive emotional memories, and activation of CRF receptors in the BLA of rats produces anxiety-like behavior. Mimicking repeated episodes of the stress response, sub-anxiogenic doses of urocortin 1 (Ucn1), a CRF receptor agonist, are microinjected into the BLA of rats for five consecutive days, a procedure called priming. This results in 1) behavioral sensitization, such that a previously non-efficacious dose of Ucn1 will elicit anxiety-like response after the 3 …
AN EXAMINATION OF SERUM CHOLESTEROL LEVEL AND SOCIODEMOGRAPHIC VARIABLES

Cardiovascular disease is the leading cause of death in the U.S. and Utah for both genders, and all racial and ethnic groups. Although many risk factors exist for cardiovascular disease, elevated total serum cholesterol levels are a major modifiable risk factor. Low income populations who have little access to health care face continual challenges in the form of environmental, social, and psychological barriers. Consequently, they are increasingly susceptible to the development of unmonitored high serum cholesterol levels and the subsequent risk of cardiovascular disease. The purpose of this study was to explore and examine the relationship between cholesterol level and socio-demographic variables, in order to work towards better prevention and screening in this population. Data was collected from the Maliheh Free Clinic located in Salt Lake City, Utah that offers health care to an underserved population who do not qualify for Medicaid or Medicare. A total of 226 patient charts were reviewed to collect data on patient characteristics and socioeconomic variables. Descriptive statistics such as chi square, T-tests, and ANOVA were performed to analyze the data. Total serum cholesterol among patients increased with age (p=.05). Mean total serum cholesterol decreased as income level increased among our sample. A higher percentage of patients in unemployed (14.0%) or unknown income (15.9%) categories were at highrisk (>= 240 mg/dL) compared to patients who had some monthly income. A higher percentage of male patients were found to be in the high risk category for total serum cholesterol level compared to female patients (13.6% vs. 11.8%). These findings allow a better understanding of the particular risks associated with serum cholesterol levels in this population. This information can be used to provide better
Catalysis in the 21st Century, Lessons from the Past, Challenges for the Future

Catalysis is a science relying on many disciplines. The advent of industrial catalytic technologies in the last century has, most often, resulted from a sequential interaction between chemists and chemical engineers, both communities developing their own fundamental and applied sciences, i.e., a multidisciplinary process. Some of the major lessons learned in the past century, and related achievements, are illustrated and discussed. Challenges for catalysis research in the 21st century are identified, based on the current knowledge of catalysis researchers, recent fundamental and applied developments, and current or long-term objectives of the global chemical industry.
4-Hydroxy-3-(1′-methyl-2-oxo-4′-phenylspiro[indoline-3,2′-pyrrolidine]-3′-ylcarbonyl)quinolin-2(1H)-one

In the title compound, C28H23N3O4, the dihedral angle between the quinoline and indole ring systems is 29.30 (5)°. The pyrrolidine ring adopts a twist conformation. An intramolecular O—H⋯O hydrogen bond generates an S(6) ring motif. A weak intramolecular C3—H3⋯O3 interaction is also observed. In the crystal, molecules are linked by two sets of N—H⋯O hydrogen bonds, forming centrosymmetric dimers containing two R 2 2(8) ring motifs. The dimers are linked via C—H⋯π interactions.
1,5-Dichloro-4,8-dinitroanthraquinone

The ring skeleton of the title compound, C14H4Cl2N2O6, is close to planar (r.m.s. deviation of the carbon atoms 0.091 Å); the nitro goups are twisted with respect to the mean plane of the ring system by 70.8 (1) and 86.7 (2)°. The crystal studied was found to be a merohedral twin, with a domain ratio of 0.61 (8):0.39 (8).
4-Carbethoxy-1-[4-(N,N-dimethylamino)benzoyl]thiosemicarbazide

The molecular structure of the title compound, C13H18N4O3S, (systematic name: ethyl N-{2-[4-(dimethylamino)benzoyl]hydrazinethiocarbonyl}carbamate) is stabilized by intramolecular N—H⋯O=C hydrogen bonding arranged in an S(6) graph-set motif. In the crystal, inversion dimers connected via intermolecular N—H⋯S=C hydrogen bonds [R 2 2(8) graph-set motif] form sheets parallel to the (21) plane. Dimers are also formed by the molecules via weak intermolecular N—H⋯S=C hydrogen bonds [R 2 2(10) graph-set motif] connecting the sheets.