Miracle-dz/UniFAR-FTUs huggingface dataset:
Obtención del ECG en una báscula de baño

El ECG es una señal común para el diagnóstico y se s uele obtener disponiendo dos o más electrodos en posicio nes predeterminadas, para poder comparar así las señale s obtenidas (derivaciones “estándar”) con los patrone s de normalidad. Pero si el ECG se desea sólo para calcul r la frecuencia cardíaca o para utilizarlo como referenc ia temporal para detectar otros eventos cardíacos, los electrod os se pueden disponer según convenga. Una posibilidad es ponerlo s en una báscula de baño que tenga dos o más electrodos (sec os) que hagan contacto con cada pie. Si simultáneamente se detecta la onda de pulso, es posible medir el tiempo de llegad a de la onda de pulso (PAT) de una forma simple, rápida y económ ica. En este trabajo se presenta un diseño capaz de obtener l ECG entre los pies en una báscula de baño y se analizan los factores que determinan la relación señal a ruido. Aplicando estos estudios al diseño de un sistema basado en una básc ula comercial con electrodos para medida de bioimpedanc ia plantar, se ha obtenido el ECG con buena relación s eñal a ruido incluso midiendo a través de calcetines.
Characterization of the mesophotic reef fish community in south Florida, USA

Summary The southeastern coast of Florida, USA supports a substantial recreational fishery, yet little is known of the coral reef ecosystem or fisheries resources past 50 m depth. Fish assemblages associated with low-relief substrate and three vessel reefs between 50 and 120 m depth off southeast Florida were surveyed by remotely operated vehicles providing the first characterization of the mesophotic fish assemblages in the region. Two distinct assemblages were observed on low-relief substrate and high-relief vessel reefs. A total of 560 fishes of 42 species was recorded on 27 dives on low-relief substrate, and 50 152 fishes of 65 species were recorded on 24 dives on three vessel reefs. Small planktivorous Anthiinae fishes and several economically valuable species were common on vessel reefs but rare on low-relief substrate. Fish assemblages on vessel reefs more closely resembled those found at similar depths in high-relief natural areas off east-central Florida and the Gulf of Mexico than those associated with adjacent low-relief habitat or nearby coral reef tracts. From a fisheries perspective, these results provide limited support to the hypothesis that in deep-water regions with limited relief, vessel reefs may provide an opportunity to increase fish diversity and abundance by creating high-relief habitat without compromising adjacent fish assemblages.
Zika virus is a global public health emergency, declares WHO

The Zika virus, and its suspected link to an increase in the number of babies born with microcephaly and a spike in neurological conditions is a global public health emergency, the World Health Organization has declared.1 2 3 4 5 6 WHO’s public health emergency committee, which met on Monday 1 February, declared that the spread of the virus was an emergency of public health concern, triggering funding into research, vector control, and efforts to stop pregnant women becoming infected. WHO’s director general, Margaret Chan, told a press conference that the virus was an “extraordinary event and a public health threat to other parts of the world. ” She said that evidence for a link between the virus and the increase in cases of microcephaly in babies and a spike in cases of …
Intermittent infusion of cladribine (CdA) in previously treated patients with low-grade non-Hodgkin's lymphoma.

Thirty-six patients with previously treated low-grade non-Hodgkin's lymphoma (LG-NHL) were included in a phase II study between August 1990 and February 1994 and treated with 0.12 mg/kg CdA as a 2 h.i. v. infusion daily x V, q 28 days up to 6 courses. Twenty-three were refractory to previous chemotherapy while 13 were relapsed. Four patients had mantle cell lymphoma, 17 follicle centre cell derived lymphoma, 7 lymphoplasmacytoid lymphomas and, 8 had small lymphocytic lymphoma. The response rate was 42%, with 5 (14%) CR and 10 (28%) PR while 6 (16%) patients progressed during treatment. The median number of delivered CdA courses was 3 (1-6) in non-responding cases and 6 (2-6) in responders. The median time to progression was 9 mo for all patients, 23 mo for CR and 16 mo for PR patients. Toxicity was sometimes severe with 3 infectious deaths (1 pneumocystis carinii pneumonia, 1 gram negative septicemia, and 1 fungal pneumonia), and 6 grade 3 or 4 infectious episodes. We conclude that responses to CdA in this group of heavily pre-treated patients is impressive. However, toxicity is considerable and the rate of opportunistic infections is worrisome.
Cardiovascular Benefits of Garlic (Allium sativum L)

Although garlic is believed to have health-promoting benefits, many of the claimed benefits are not supported by good scientific studies. This review critically examined current scientific literature concerning claims of cardiovascular benefits from regular consumption of garlic or garlic preparations. The vast majority of recent randomized, placebo-controlled studies do not support a role for garlic in lowering blood lipids. There also is insufficient evidence to support a role in reducing blood pressure. While there have been indications of antiatherosclerotic effects associated with garlic consumption, there are insufficient data in humans. Investigation of antithrombotic effects of garlic consumption appears to hold promise, but too few data exist to draw firm conclusions.
Phosphorylase Kinase Inhibition Therapy in Burns and Scalds

Severe burns and scalds almost always result in unsightly hypertrophic scarring. Among the important processes involved in scarring are fibroblast formation and transformation of fibroblasts into myofibroblasts. Myofibroblasts contain α-smooth muscle actin which has contractile properties and can lead to wound contraction and hypertrophic scarring. Phosphorylase kinase (PhK), expressed within 5 mins of injury, is among the earliest enzymes released after tissue damage. It is responsible for activation of NF-kB, which in turn activates over 200 different genes related to inflammation, fibroblastic proliferation, myofibroblast conversion, and eventual scar tissue formation. The sequence and approximate timing of events following injury include the following: activation of PhK (5 mins), followed by appearance of neutrophils (30 mins), macrophages (hours to days), fibroblasts (1 week) and myofibroblasts (2 weeks). Cytokines and growth factors secreted by macrophages include fibroblast growth factor (FGF) and transforming growth factors α and β (TGFα and TGFβ). Fibroblast growth factor is responsible for fibroblastic proliferation, and TGFβ1 for conversion of fibroblasts into myofibroblasts. After thermal injury, the use of topical curcumin, a non-competitive, selective PhK inhibitor that blocks PhK activity upstream of NF-kB activation, was found to be associated with more rapid and improved skin healing, as well as less severe or absent scarring. ‡ © Heng M. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A temperature dependent empirical model for AlGaN/GaN HEMTs including charge trapping and self-heating effects

This paper presents a temperature dependent empirical model for GaN HEMTs with the consideration of charge trapping and self-heating effects. A new 13-element drain current source (Ids) model is proposed. The current dispersion deduced by trapping and thermal effects is generally modeled by Taylor expansion, and for the first time, the dispersion related coefficients are rigorously derived to be the combination of analytical Ids functions. The Ids model is manifested by the accurate prediction of massive measured PIVs with various quiescent biases and power dissipation. The large signal model is implemented in Advanced Design System (ADS), and the simulations of both DC and RF characteristics well agree with the measurements.
Relationship between cortisol level and prevalent/incident cognitive impairment and its moderating factors in older adults

ABSTRACT Background: The objectives of this study were to examine the factors modifying the relationship between cortisol level and prevalent/incident cognitive impairment in older adults and to verify whether these relationships were non-linear. Methods: Data were collected from 1,226 individuals aged 65 and older by two in-home interviews separated by 12 months. Cortisol level was measured using saliva samples taken at the beginning of the baseline interview before cognitive, mental, and physical health evaluations. Prevalent and incident cognitive impairment were defined using the Mini-Mental State Examination scores according to normative data for age, education level, and sex. Results: High morning cortisol level increased the risk of incident cognitive impairment in participants with anxiety or depressive episode while low cortisol level increased the risk in participants without anxiety or depressive episode. In high educated participants, but not in low educated participants, high morning cortisol level was associated with prevalent cognitive impairment and high afternoon cortisol level increased the risk of incident cognitive impairment. The results also suggested that lower morning cortisol values could increase the risk of incident cognitive impairment in individuals with few chronic diseases. A curvilinear relationship was observed between morning cortisol and the probability of incident cognitive impairment, but further analyses suggested that it was likely explained by anxiety and depressive episode. Conclusions: These results suggest that cognitive impairment in older adults is linked to higher or lower cortisol level depending on characteristics such as anxiety, depressive episode, education level, and physical health.
Food induced anaphylaxis ‐death can and must be avoided

M any doctors would consider that anaphylaxis, or anaphylactoid reactions, are most often caused by a hypersensitivity to bee or wasp venom, drugs such as penicillin, or contrast media. There is certainly a morbidity and mortality from these causes, but at least in the experience of some allergists food-induced reactions are a major cause of anaphylaxis. 1 Unfortunately there is a paucity of data on either the prevalence of severe food allergy or the frequency of anaphylactic deaths from this cause. Allergic reactions can be confused with acute illness from infective, toxic, metabolic or idiosyncratic causes. The International Classification of Diseases has no code for food anaphylaxis. At times a sudden death from al1 ergy may be recorded inappropriately as due to myocardial infarction, status asthmaticus or sudden infant death syndrome. Deaths and near-fatal reactions from allergy do occur and occasionally are well-documented, causing a flurry of interest in the medical and lay press before the subject again passes from memory.2,3
Elicitor effect of chitosan and pectin on the biosynthesis of anthraquinones, phenolics and flavonoids in adventitious root suspension cultures of Morinda citrifolia (L.).

In this study, the effect of chitosan and pectin on the accumulation of anthraquinones (AQ), phenolics and flavonoids was investigated by adventitious root suspension cultures of Morinda citrifolia in shake flasks. Adventitious root cultures elicitor treated with various combinations of chitosan and pectin or chitosan alone resulted in enhanced biosynthesis of secondary metabolite but inhibited root growth. The strong inhibition of root growth might be due to the lethal effect of elicitor as evidenced by 36-79% cell death was measured. The optimum concentration of elicitor for enhancing metabolite biosynthesis was found at the concentration of 0.2 mg ml -1 chitosan, in which 103.16, 48.57 and 75.32 mg g -1 dry weight (DW) of AQ, phenolics and flavonoids, respectively were achieved. To elucidate the optimum contact period and reduction of inhibitory effect of chitosan on root growth, a two-stage culture system was adopted. The optimum contact period of root to elicitor was observed when adventitious culture was elicitor treated with 0.2 mg ml -1 chitosan on day 28 and harvest after 2 days of elicitation. Although, root growth slightly decreased by this treatment, the yield of AQ, phenolics and flavonoids was enhanced by 45%, 8% and 12%, respectively compared to without elicitor treated culture.
The price of lost freedom: entropy of bimolecular complex formation.

Molecules in solution have degrees of freedom representing overall movements of translation and rotation, internal vibrations and rotations about single bonds. The entropy and the free energy associated with these degrees of freedom can be calculated with high precision for simple molecules in the gas phase. The calculation can be extended under certain conditions to larger molecules and to proteins
Effectiveness of mindfulness-based stress reduction in mood, breast- and endocrine-related quality of life, and well-being in stage 0 to III breast cancer: a randomized, controlled trial.

PURPOSE To assess the effectiveness of mindfulness-based stress reduction (MBSR) for mood, breast- and endocrine-specific quality of life, and well-being after hospital treatment in women with stage 0 to III breast cancer. PATIENTS AND METHODS A randomized, wait-listed, controlled trial was carried out in 229 women after surgery, chemotherapy, and radiotherapy for breast cancer. Patients were randomly assigned to the 8-week MBSR program or standard care. Profile of Mood States (POMS; primary outcome), Functional Assessment of Cancer Therapy-Breast (FACT-B), Functional Assessment of Cancer Therapy-Endocrine Symptoms (FACT-ES) scales and the WHO five-item well-being questionnaire (WHO-5) evaluated mood, quality of life, and well-being at weeks 0, 8, and 12. For each outcome measure, a repeated-measures analysis of variance model, which incorporated week 0 measurements as a covariate, was used to compare treatment groups at 8 and 12 weeks. RESULTS There were statistically significant improvements in outcome in the experimental group compared with control group at both 8 and 12 weeks (except as indicated) for POMS total mood disturbance (and its subscales of anxiety, depression [8 weeks only], anger [12 weeks only], vigor, fatigue, and confusion [8 weeks only]), FACT-B, FACT-ES, (and Functional Assessment of Cancer Therapy subscales of physical, social [8 weeks only], emotional, and functional well-being), and WHO-5. CONCLUSION MSBR improved mood, breast- and endocrine-related quality of life, and well-being more effectively than standard care in women with stage 0 to III breast cancer, and these results persisted at three months. To our knowledge, this study provided novel evidence that MBSR can help alleviate long-term emotional and physical adverse effects of medical treatments, including endocrine treatments. MBSR is recommended to support survivors of breast cancer.
Kinase Signaling in the Spindle Checkpoint*

The spindle checkpoint is a cell cycle surveillance system that ensures the fidelity of chromosome segregation. In mitosis, it elicits the “wait anaphase” signal to inhibit the anaphase-promoting complex or cyclosome until all chromosomes achieve bipolar microtubule attachment and align at the metaphase plate. Because a single kinetochore unattached to microtubules activates the checkpoint, the wait anaphase signal is thought to be generated by this kinetochore and is then amplified and distributed throughout the cell to inhibit the anaphase-promoting complex/cyclosome. Several spindle checkpoint kinases participate in the generation and amplification of this signal. Recent studies have begun to reveal the activation mechanisms of these checkpoint kinases. Increasing evidence also indicates that the checkpoint kinases not only help to generate the wait anaphase signal but also actively correct kinetochore-microtubule attachment defects.
Spinal Fusion After Revision Surgery for Pseudarthrosis in Adult Scoliosis

Study Design. A retrospective study. Objective. To decipher the incidence, characteristics, functional outcomes, and complications of spinal fusion after revision surgery for recurrent pseudarthrosis in adult patients with scoliosis. Summary of Background Data. While the rate of spinal fusion has been examined in the past, there have been no studies that have examined the incidence, characteristics, functional outcomes, and complications of spinal fusion after pseudarthrosis repair in adult patients with scoliosis. Materials and Methods. A total of 132 patients with failed spinal fusion surgery for adult scoliosis and painful pseudarthroses were studied. Each patient had an average of 3.7 spinal surgeries before undergoing revision at our institution. In addition to clinical assessment and imaging studies, pseudarthrosis was confirmed intraoperatively in all patients. All patients underwent reinstrumentation and fusion along with adjunctive procedures as needed. Spinal fusion was assessed clinically and radiographically after surgery for a minimum of 40 months. Subjective functional outcomes and complications associated with the procedures were also studied. Results. The overall incidence of spinal fusion after revision surgery for pseudarthrosis in adult scoliosis was 90%. There was a propensity for pseudarthrosis to recur at the thoracolumbar and lumbosacral junctions. Increasing thoracolumbar kyphosis and loss of sagittal balance were significant risk factors for recurrent pseudarthrosis after revision surgery (mean thoracolumbar kyphosis of 23° and mean sagittal balance of 7.9 cm anteriorly associated with persistent pseudarthrosis). Additionally, patients with multiple preoperative sites of pseudarthroses were at a higher risk for continued pseudarthrosis after surgery. Cigarette smoking, age, and surgical approach did not have any significant correlation with pseudarthrosis. Seventy-two percent of patients were satisfied with the outcome and 80% would have chosen to undergo surgery again if necessary. Thirty-three percent of patients who underwent surgery had some complication related to the surgery. Conclusion. Revision surgery for pseudarthrosis repair in adult scoliosis is most successful at attaining fusionwhen thoracolumbar and overall sagittal alignment are restored as much as possible.
Memory lymphocytes from tuberculous effusions: purified protein derivative (PPD) stimulates accelerated activation marker expression and cell cycle progression

Accelerated PPD‐specific proliferation and generation of CD4+ cytotoxic effectors by mononuclear leucocytes (MNL) from tuberculous effusions (EMNL) has been previously reported by our laboratory. In order to explore the contribution of the state of activation of MNL to accelerated reactivity, EMNL and peripheral blood (PB)MNL from seven patients with tuberculosis were assessed both ex vivo and after PPD stimulation. Flow cytometry revealed no difference in the activation state (IL‐2 receptor and HLA‐DR expression) or cell cycle progression ex vivo. However, CD4+CD29+ memory T cells were accumulated in EMNL compared with PBMNL. In vitro stimulation of EMNL with PPD resulted in accelerated expression of activation markers and progression through the cell cycle (peak after 4 days), whilst PBMNL exhibited normal activation kinetics (peak after 7 days). Accelerated reactivity could not be accounted for by quantitative differences in effusion CD4+CD29+ memory T cells compared with blood, but may be due to a qualitative difference in effusion memory T cells, which are shown to be in a post‐activation state of differentiation. T cells entering S and G2/M phases of the cell cycle were largely of the activated memory phenotype. Activation marker expression occurred in association with up‐regulation of CD4 antigen expression on the surface of EMNL. Thus accelerated expression of activation markers and cell cycle progression by CD4+CD29+ memory T cells may in part account for accelerated PPD reactivity in tuberculous effusions.
A Review: Carbon Nanotube-Based Piezoresistive Strain Sensors

The use of carbon nanotubes for piezoresistive strain sensors has acquired significant attention due to its unique electromechanical properties. In this comprehensive review paper, we discussed some important aspects of carbon nanotubes for strain sensing at both the nanoscale and macroscale. Carbon nanotubes undergo changes in their band structures when subjected to mechanical deformations. This phenomenon makes them applicable for strain sensing applications. This paper signifies the type of carbon nanotubes best suitable for piezoresistive strain sensors. The electrical resistivities of carbon nanotube thin film increase linearly with strain, making it an ideal material for a piezoresistive strain sensor. Carbon nanotube composite films, which are usually fabricated by mixing small amounts of single-walled or multiwalled carbon nanotubes with selected polymers, have shown promising characteristics of piezoresistive strain sensors. Studies also show that carbon nanotubes display a stable and predictable voltage response as a function of temperature.
[Chemotaxis and inflammation].

In what case do you like reading so much? What about the type of the chemotaxis and inflammation book? The needs to read? Well, everybody has their own reason why should read some books. Mostly, it will relate to their necessity to get knowledge from the book and want to read just to get entertainment. Novels, story book, and other entertaining books become so popular this day. Besides, the scientific books will also be the best reason to choose, especially for the students, teachers, doctors, businessman, and other professions who are fond of reading.
Evaluation of liver fibrosis with T1ρ MR imaging.

Chronic liver disease is a major public health problem worldwide. Liver fibrosis, a common feature of almost all chronic liver diseases, involves the accumulation of collagen, proteoglycans, and other macromolecules in the extracellular matrix. The accumulation of proteins in the extracellular matrix promotes the formation of scars that bridge together adjacent portal triads and central veins. Ultimately, progressive hepatic fibrosis leads to cirrhosis, a characteristic of all end-stage liver disease. Clinically, liver fibrosis usually has an insidious onset and progresses slowly over decades. Patients remain asymptomatic or have only mild, nonspecific symptoms until the development of cirrhosis (1). To date, the conventional imaging diagnostic tests available in clinical practice are not sensitive or specific enough to function as screening tests for detecting liver fibrosis. In patients with precirrhotic stages of liver fibrosis, as well as patients with early cirrhosis, the liver parenchyma usually has a normal appearance or may exhibit only subtle, nonspecific heterogeneity on conventional MR images. A number of MR imaging techniques have been investigated to identify or to assign a grade to liver cirrhosis. These include double contrast material-enhanced MR imaging (2), MR elastography (3-5), and diffusion weighted imaging (3,5,6). The reproducibility and intersite variability of these techniques have not been well established. A mechanism for magnetic resonance (MR) tissue contrast, spin-lattice relaxation time in the rotating frame (T1ρ), has been investigated in biomedical applications. In T1ρ imaging, the equilibrium magnetization, M0, established by the static magnetic field, B0, is flipped into the transverse plane first. This magnetization in the transverse plane relaxes like a normal free induction decay but in the presence of an onresonant continuous wave radiofrequency pulse, which is much weaker than B0 and is called spin-lock radiofrequency pulse. The relaxation rate constant of this transverse magnetization