Miracle-dz/UniFAR-FTUs huggingface dataset:
Geographic Variation and Sexual Size Dimorphism in Mauremys mutica (Cantor, 1842) (Reptilia: Bataguridae), with Description of a New Subspecies from the Southern Ryukyus, Japan

Abstract The batagurid turtle, Mauremys mutica, is widely distributed in tropical to temperate East Asia. Analyses of morphometric characters and coloration revealed that the southern Ryukyu populations of this species are much diverged from the other populations, presumably as a result of their long geographical isolation. We describe those populations as a new subspecies, M. m. kami. Analysis of geographic variation also suggested that distinctly isolated populations of the central and northern Ryukyus, and Kyoto and Shiga Prefectures of central Japan have originated from animals artificially introduced from the Yaeyama Group, and Taiwan, respectively. We confirmed the absence of “larger female” sexual size dimorphism (SSD) in M. mutica unlike most other aquatic batagurids, and further demonstrated variation in SSD pattern between the subspecies: in M. m. kami, the adult male has a significantly greater carapace length than adult females, whereas the adult carapace length does not differ significantly between sexes in the nominotypical subspecies. It is hypothesized that these dimorphic patterns evolved from the widely prevailing “larger female” condition through epigamic selection involving forcible copulatory behavior.
达托霉素治疗血液病合并革兰阳性菌感染患者11例临床观察

胞MV-4-11的抑制作用[J]. 中国肿瘤生物治疗杂志, 2014, 21 (1):20-24. [12] Zhang W, Konopleva M, Shi YX, et al. Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia[J]. J Natl Cancer Inst, 2008, 100(3):184-198. [13] Crump M, Hedley D, Kamel-Reid S, et al. A randomized phase I clinical and biologic study of two schedules of sorafenib in patients with myelodysplastic syndrome or acute myeloid leukemia: a NCIC (National Cancer Institute of Canada) Clinical Trials Group Study[J]. Leuk Lymphoma, 2010, 51(2): 252-260. [14] Richly H, Kupsch P, Passage K, et al. Results of a phase I trial of BAY 43-9006 in combination with doxorubicin in patients with primary hepatic cancer[J]. Int J Clin Pharmacol Ther, 2004, 42 (11):650-651. [15]Ravandi F, Cortes JE, Jones D, et al. Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia[J]. J Clin Oncol, 2010, 28(11):1856-1862. [16] Inaba H, Rubnitz JE, Coustan-Smith E, et al. Phase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed/refractory leukemia[J]. J Clin Oncol, 2011, 29 (24):3293-3300. [17] Serve H, Krug U, Wagner R, et al. Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebocontrolled trial [J]. J Clin Oncol, 2013, 31(25): 3110-3118. [18] Wolleschak D, Schalk E, Krogel C, et al. Rapid induction of complete molecular remission by sequential therapy with LDAC and sorafenib in FLT3ITD-positive patients unfit for intensive treatment: two cases and review of the literature[J]. J Hematol Oncol, 2013, 6: 39. [19] Metzelder S, Wang Y, Wollmer E,et al. Compassionate use of sorafenib in FLT3ITDpositive acute myeloid leukemia: sustained regression before and after allogeneic stem cell transplantation[J]. Blood, 2009, 113(26):6567-6571. [20] Sharma M, Ravandi F, Bayraktar UD, et al. Treatment of FLT3ITD-positive acute myeloid leukemia relapsing after allogeneic stem cell transplantation with sorafenib[J]. Biol Blood Marrow Transplant, 2011,17(12):1874-1877. [21] Man CH, Fung TK, Ho C, et al. Sorafenib treatment of FLT3ITD(+)acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation[J]. Blood, 2012, 119(22): 5133-5143. (收稿日期:2014-07-29) (本文编辑:王叶青)
ALL儿童方案序贯造血干细胞移植治疗T淋巴母细胞淋巴瘤疗效及预后因素分析

目的 探讨经急性淋巴细胞白血病（ALL）儿童方案治疗达到完全缓解（CR）和部分缓解（PR）的T淋巴母细胞淋巴瘤（T-LBL）患者应用造血干细胞移植巩固治疗的疗效及预后因素。 方法 收集2013年1月至2017年1月于唐都医院血液病中心接受治疗的T-LBL患者的临床资料，将达到CR或PR的患者纳入研究，进行回顾性分析。 结果 ①48例患者接受了ALL儿童方案治疗，经2个疗程的诱导化疗后39例达CR，9例达PR。 其中接受自体造血干细胞移植（auto-HSCT）者14例，接受异基因造血干细胞移植（allo-HSCT）者7例，21例患者移植后造血功能均顺利重建。 ②中位随访时间31（9～16）个月。 3年总生存（OS）率为61. 0%（95% CI 53.7%～68.3%），3年无进展生存（PFS）率为54. 8%（95% CI 47.1%～62.2%）。 ③移植组和未移植组3年OS率分别为84. 7%和42. 8%（P＝0.006），两组3年PFS率分别为75. 4%和38. 9%（P＝0.004）。 ④auto-HSCT组与allo-HSCT组患者的OS率、PFS率差异均无统计学意义（P值分别为0. 320、0.597）。 ⑤骨髓侵犯、未接受造血干细胞移植是影响患者长期预后的独立危险因素［ HR＝5.804（95% CI 1.140～29.549），P＝0.034；HR＝5.871（95% CI 1.711～20.140），P＝0.005］。 结论 ALL儿童方案化疗序贯造血干细胞移植治疗T-LBL疗效确切，安全性好。 auto-HSCT与allo-HSCT患者的OS率及PFS率差异均无统计学意义。 骨髓侵犯、未接受造血干细胞移植是影响T-LBL患者长期预后的独立危险因素。
178例原发性血小板增多症患者的基因突变谱及临床特征

目的 分析原发性血小板增多症（ET）患者基因突变谱及临床特征。 方法 对2009年2月1日至2018年11月1日收治的178例初诊ET患者进行回顾性分析。 结果 全部178例患者中，男89例，女89例，中位初诊年龄为49. 5（3~86）岁。 JAK2V617F基因突变频率为16. 45%（1.67%~43.90%），CALR基因突变频率为40.00%（10.00%~49.15%），MPL基因突变频率为25. 10%（25.00%~40.00%）。 与CALR基因突变的患者相比，JAK2V617F基因突变患者具有较高的发病年龄（P=0.035）、初诊白细胞计数（P=0.040）、初诊血红蛋白浓度（P=0.001）和较低的初诊血小板计数（P=0.002）。 47例（27.01%）患者诊断ET前发生血栓事件，3例（1.72%）诊断ET后发生血栓事件。 多因素分析结果显示，年龄>60岁（P=0.013，OR=4.595，95%CI1.382~15.282）、心血管危险因素（P<0.001，OR=8.873，95%CI2.921~26.955）为血栓事件的危险因素，CALR基因突变（P=0.032，OR=0.126，95%CI0.019~0.838）为血栓事件的保护性因素。 年龄>60岁（P=0.042，OR=4.045，95%CI1.053~15.534）是影响ET患者总生存时间的危险因素。 年龄≤60岁、年龄>60岁患者的OS时间分别为（115.231±1.899）、（83.291±4.991）个月（χ2=6.406，P=0.011）。 结论 心血管危险因素、年龄>60岁为ET患者血栓事件的危险因素，CALR基因突变为血栓事件的保护性因素。 年龄>60岁是影响ET患者总生存的危险因素。
Habitat use by demersal nekton on the continental shelf in the Benguela ecosystem, southern Africa.

Abstract– Videotapes collected by the research submersible ago J in the Ben­guela ecosystem during spring 1997 were analyzed to determine demersal nekton assemblage composition, ﬁsh be­havior, and microscale habitat asso­ciation, and habitat selection. Demersal ﬁsh assemblage diversity was gen­ erally low, and their composition was a function of substratum type. Individual species showed an often marked asso­ciation with either rocky or soft sub­strata (or both), and a strong or weak selection for the associated biota. Soles and dragonets actively selected areas of bioactive soft substrata, to which they are behaviorally and morphologically adapted. False jacopever were associ­ated with crevices in areas of high-re­lief rocky substrata. Kingklip are pis­civorous and were largely conﬁned to holes at the base of rocks and favored areas without a conspicuous epifauna. Juvenile hake and gobies avoided ex­tremely rocky areas and were largely indifferent to the presence of benthic invertebrates—behavior that is con­sistent with their planktonic diets. These results represent the ﬁrst direct observations of demersal nekton in the region and are important because they allow better interpretations of the results of trawl studies. Manuscript accepted 23 January 2002. Fish. Bull. 100:475–490 (2002).
伴AML1-ETO融合基因的急性髓系白血病患者ASXL2基因突变及临床特征分析

目的 探讨伴AML1-ETO融合基因的急性髓系白血病（AML）患者ASXL2基因突变情况、突变阳性患者临床特征及ASXL2基因突变与c-kit基因突变的关系。 方法 采用PCR扩增产物片段直接测序分析法，检测59例伴AML1-ETO融合基因初发AML患者ASXL2基因第11、12外显子编码区突变情况，比较ASXL2基因突变阳性和阴性组患者的临床特征、生存及c-kit基因突变情况。 结果 59例患者中7例存在ASXL2突变，突变率为11. 9%。 ASXL2基因突变阳性组患者初诊时外周血红蛋白浓度中位数为56. 2（38.0~72.0）g/L，显著低于ASXL2突变阴性组患者的69. 0（37.2~154.0）g/L，差异有统计学意义（P=0.038）；外周血WBC、PLT、嗜酸粒细胞比例、骨髓原始细胞比例与ASXL2突变阴性组相比，差异均无统计学意义（P值均>0.05）。 两组均未见肝、脾、中枢神经系统浸润；淋巴结不同程度肿大，但ASXL2基因突变阳性、阴性两组间差异无统计学意义（P=0.859）。 免疫表型分析显示：ASXL2基因突变阳性组CD33表达显著低于阴性组（P=0.033）；两组患者均未表达cCD3，CD117、cMPO、HLA-DR、CD34、CD38、CD13、CD44、CD15、CD64、CD11b、CD56、CD19、cCD79a、CD7两组表达差异均无统计学意义（P值均>0.05）。 ASXL2基因突变阳性与阴性组患者总缓解率、总生存时间差异均无统计学意义（P值分别为0. 577、0.631）。 两组c-kit基因突变检出率分别为14. 3％和29. 4%，差异无统计学意义（P=0.697）。 结论 该组伴AML1-ETO融合基因AML患者ASXL2基因突变率为11. 9%。 ASXL2突变阳性患者外周血红蛋白浓度、CD33表达方面呈现一定的临床特征。 ASXL2基因突变与c-kit基因变突可能没有特定的关联性。
急性髓系白血病微小残留病研究现状及展望

Current situation and prospect of minimal residual disease in acute myeloid leukemia Li Shuxin, Chang Yingjun, Wei Hui Institute of Hematology & Blood Disease Hospital, CAMS & PUMC, Tianjin 300020, China; Peking University People’s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China Corresponding author: Wei Hui, Email: weihui@ihcams.ac. cn
Autolysis of squid mantle muscle protein as affected by storage conditions and inhibitors

Autolysis of squid mantle muscle was investigated under various conditions using muscle homogenate as a model system. Cleavage of myosin into heavy and light meromyosin was prominent during autolysis. Storage conditions such as NaCl concentration and temperature affected not only the rate of autolysis but also the products formed. Conditions for maximal autolysis were: NaCl concentration 0.3M, pH 7 and temperature 40°C. Autolysis was well inhibited by ethylenediaminetetra acetic acid and Na-pyrophosphate at 35°C suggesting two different types of proteinases were involved.
Human Infection Challenge Studies: a Test for the Social Value Criterion of Research Ethics

Human infection challenge studies involving the intentional infection of research participants with a disease-causing agent have recently been suggested as a means to speed up the search for a vaccine for the ongoing coronavirus disease 2019 (COVID-19) outbreak. Calls for challenge studies, however, rely on the expected social value of these studies. This value represents more than the simple possibility that a successful study will lead to the rapid development and dissemination of vaccines but also some expectation that this will actually occur. ABSTRACT Human infection challenge studies involving the intentional infection of research participants with a disease-causing agent have recently been suggested as a means to speed up the search for a vaccine for the ongoing coronavirus disease 2019 (COVID-19) outbreak. Calls for challenge studies, however, rely on the expected social value of these studies. This value represents more than the simple possibility that a successful study will lead to the rapid development and dissemination of vaccines but also some expectation that this will actually occur. I show how this expectation may not be realistic in the current political moment and offer potential ways to make sure that any challenge trials that arise actually achieve their goals.
抗磷脂综合征血栓与出血的机制与治疗

DOI:10.3760/cma.j.issn.0253-2727.2017. 11.022 基金项目:江苏省科教兴卫工程-临床医学中心(ZX201102);江 苏省血液病临床医学研究中心(江苏省科技厅生命健康专项 BL2012005) 作者单位:215006 苏州大学附属第一医院,江苏省血液研究 所;卫生部血栓与止血重点实验室,血液学协同创新中心 通信作者:王兆钺,Email:zwang11@sina.com Mechanisms and management of thrombosis and bleeding in antiphospholipid syndrome Wang Zhaoyue Corresponding author: Wang Zhaoyue, Key Lab of Thrombosis and Hemostasis of Ministry of Health, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. Email: zwang11@sina. com
Research on the chemical characterization of meat harvested from rabbits and hares.

Due to the need to enlarge the range meats and respond to consumer demand for meat with lower fat content, especially of cholesterol, we considered it appropriate to make a comparative study on the characterization of meat rabbits and hares. It notes the concern of people today to find healthy food alternatives, low in fat and carbohydrates, but rich in protein, vitamins and minerals. Rabbit meat is a healthy alternative, having a very high protein and low in cholesterol content , but its value of nutrition and dietetics is not enough explained. The purpose of this paper is to highlight its nutritional value through the high protein and mineral content and low in fat content. It has been determined the quantity of protein, fat, water and collagen in the main muscle groups of carcasses of hares and rabbits.
Drought stress‐induced changes in the composition and physical state of phospholipids in wheat

Seedlings of winter wheat (Triticum aestivum L. cv. Jubilejnaja 50) were grown under normal and dry conditions. Frost resistance (LT50) of 10-day-old control seedlings was −6°C. LT50 of the subsequently drought-stressed leaves shifted to −16°C. In plants of the same physiological age (28 days) but grown without stress, LT50 was −12°C. Phosphatidylcholine accumulated and phosphatidylethanolamine decreased in drought-stressed leaves. Fatty acid unsaturation of these phospholipids increased with leaf age, independently of water supply. Both ageing and drought stress produced a decrease in the apparent phase separation temperature of isolated total phospholipids as determined by electron spin resonance. The possible role of dehydration-induced structural changes in the bilayer matrix in triggering adaptive alterations in membrane composition, similar to those observed during cold hardening, is discussed.
慢性中性粒细胞白血病合并多发性骨髓瘤二例报告并文献复习

目的 探讨慢性中性粒细胞白血病（CNL）合并多发性骨髓瘤（MM）的诊断和治疗。 方法 总结2例CNL合并MM患者的临床特征、分子生物学特点，对其诊断、治疗进行回顾性分析。 结果 2例患者均符合CNL合并MM的诊断。 例1随着MM达完全缓解，中性粒细胞计数恢复正常；MM复发后，中性粒细胞计数再次升高。 例1行CSF3R、SETBP1基因突变检查显示，CSF3R外显子17突变阳性（P733T），外显子14突变阴性；SETBP1基因突变阴性。 应用针对MM的方案治疗后，随着MM病情的控制，CNL亦可缓解。 结论 CNL合并MM临床罕见。 CSF3R基因突变对于CNL的诊断具有重要意义。 CNL合并MM伴CSF3R P733T突变为国际首次报道。 针对MM的方案可有效治疗CNL合并MM。
细胞遗传学检测在慢性髓性白血病中的临床意义

目的 探讨酪氨酸激酶抑制剂（TKI）时代，慢性髓性白血病（CML）病程演进与细胞遗传学的关系。 方法 应用骨髓细胞短期培养法，对387例初诊CML患者行染色体G显带技术核型分析，结合ABL激酶区点突变检测分析细胞遗传学变化与CML病程演进的关系。 结果 间接荧光原位杂交（FISH）技术检测387例CML患者BCR-ABL融合基因阳性，其中Ph+CML占94. 1%（364/387），Ph− CML占5. 9%（23/387）；标准易位t（9; 22）（q34；q11）320例（87.9%），变异易位5例（1.4%），初诊Ph+合并额外染色体异常（ACA）39例（10.7%）。 合并ACA中“主要路径”异常22例（56.4%），“次要路径”异常15例（38.5%），−Y异常2例（5.1%）。 23.4%（71/303）标准易位患者在TKI治疗中出现ACA，主要为染色体数目异常，此类患者疾病进展比例高（χ2=168.21，P<0.001）、更易合并点突变（χ2=29.04，P<0.001）。 初诊CML慢性期合并ACA患者与标准易位患者相比，有较低的无事件生存（EFS）及无病生存（DFS）率（P值分别为0. 037和0. 003），但总生存（OS）率差异无统计学意义（P=0.209）。 CML慢性期患者TKI治疗过程中出现ACA者与无ACA者相比，OS、EFS、DFS率均降低（P值均<0.001）。 进展期合并ACA患者长期生存率下降（P=0.086）。 结论 CML在病程演进中往往合并ACA，此类患者更易发生不良事件或疾病进展，在TKI治疗过程中规律、及时行染色体核型分析及点突变检测对疗效评估及预后判断具有重要意义。
Integrating Evolution and Development: The Need for Bioinformatics in Evo-Devo

Abstract This article is an overview of concepts relating to the integration of the genotype and phenotype. One of the major goals of evolutionary developmental biology, or evo-devo, is to understand the transformation of morphology in evolution. This goal can be accomplished by synthesizing the data pertaining to gene regulatory networks and making use of the increasingly comprehensive knowledge of phylogenetic relationships and associated phenotypes. I give several examples of recent success in connecting these different biological levels. These examples help illuminate the “black box” between genotype and phenotype and illustrate a few of the technical and bioinformatic challenges ahead. The key concept of modularity unites genetic, developmental, and evolutionary approaches, because modules are the units of evolution. Primitive and derived network modules interact in development to create the phenotype. To obtain a systems-level understanding of evolutionary phenotypic change, bioinformatics approaches involving ontologies need to be applied, and new methods of visualization need to be developed.
Individual Variation of Foraging Behavior and Food Provisioning in Adélie Penguins (Pygoscelis adeliae) in a Fast-Sea-Ice Area

ABSTRACT. To understand the effects of foraging behavior on the amount of food provided to chicks (meal mass and frequency), we monitored nest attendance and diving behavior of 20 Adélie Penguin (Pygoscelis adeliae) pairs that were rearing chicks. Because ice forms on the sea surface at night, parents foraged through cracks or within leads in the sea ice mainly during 0800–2400 hours. Birds that departed the colony in the afternoon and returned in the evening of the same day fed their chicks more frequently than those that made longer trips (i.e., those that departed in the afternoon and returned the next day or departed in the early morning and returned that evening). When the duration of the longest dive bout during each trip was longer, parents brought back heavier meals that contained larger krill. On average, birds made longer dive bouts when diving to greater depths. Thus, daily foraging pattern and foraging depth affected the provisioning rate, but the proportion of time spent foraging during the potential foraging period, total underwater time per day, and parental body condition were not. We suggest that temporal variability in prey availability and individual differences in foraging behavior affect the provisioning rate and, thus, chick growth.
Oxidative damage and defense mechanisms in primary leaves of Phaseolus vulgaris as a result of root assimilation of toxic amounts of copper

We studied the sequence of several metabolic reactions, representative for oxidative damage and protection, in primary leaves of Phaseolus vulgaris (cv. Limburgse vroege) as a function of root assimilation of a toxic sublethal Cu concentration (630 μM). A transient increase of products of membrane peroxidation was observed in the primary leaves during the period of Cu uptake. This rise was mainly due to the oxidizing properties of copper itself and not to a stimulation of the lipoxygenase (EC 1.13.11.12) activity. In our experimental conditions, membrane lipid peroxidation and K + -leakage were not directly related ; during at least three days after Cu application to the roots, when products of lipid peroxidation were already detected in the leaf, permeability of the cytoplasmic membrane for K + was improved. However, Cu stimulated the capacity of catalase (EC 1.11.1.6) and ascorbate peroxidase (EC 1.11.1.11). These enzymes protect the tissue against oxidative stress since at least the hydrogen peroxide content was significantly reduced. Superoxide dismutase (EC 1.15.1.1) was not involved in this defense mechanism.
Complete Genome Sequence of Bifidobacterium adolescentis ZJ2, Isolated from a Centenarian in Anhui, China

In this announcement, we present the complete genome sequence of Bifidobacterium adolescentis strain ZJ2, which was isolated from a female centenarian in Anhui, China. The final genome consists of a 2,401,766-bp chromosome with a G+C content of 59.90%. ABSTRACT In this announcement, we present the complete genome sequence of Bifidobacterium adolescentis strain ZJ2, which was isolated from a female centenarian in Anhui, China. The final genome consists of a 2,401,766-bp chromosome with a G+C content of 59.90%.
Complete Genome Sequence of a Tomato Brown Rugose Fruit Virus Isolated in the United States

The complete genome sequence of a U.S. isolate of a Tomato brown rugose fruit virus (ToBRFV) (CA18-01) was obtained through Illumina and MinION sequencing. The U.S. ToBRFV isolate shared a high nucleic acid sequence identity (>99%) with known ToBRFV isolates. Phylogenetic analysis revealed a tight cluster for ToBRFV isolates throughout the world, suggesting a short evolutionary history. ABSTRACT The complete genome sequence of a U.S. isolate of a Tomato brown rugose fruit virus (ToBRFV) (CA18-01) was obtained through Illumina and MinION sequencing. The U.S. ToBRFV isolate shared a high nucleic acid sequence identity (>99%) with known ToBRFV isolates. Phylogenetic analysis revealed a tight cluster for ToBRFV isolates throughout the world, suggesting a short evolutionary history.
Science has always been political

This month marks the 75th anniversary of Vannevar Bush's paper, “Science—The Endless Frontier. ” The report set out the rationale and structure of a system to fund science in the United States; it is the Magna Carta of American science. Science published a summary of Bush's paper on the same day it was submitted to President Harry Truman, and Bush's close relationship with the magazine is evident by the number of times he wrote and was quoted in Science during the 1940s.
Machine learning-driven intrusion detection for Contiki-NG-based IoT networks exposed to NSL-KDD dataset

Wide adoption of Internet of Things (IoT) devices and applications encounters security vulnerabilities as roadblocks. The heterogeneous nature of IoT systems prevents common benchmarks, such as the NSL-KDD dataset, from being used to test and verify the performance of different Network Intrusion Detection Systems (NIDS). In order to bridge this gap, in this paper, we examine specific attacks in the NSL-KDD dataset that can impact sensor nodes and networks in IoT settings. Furthermore, in order to detect the introduced attacks, we study eleven machine learning algorithms and report the results. Through numerical analysis, we show that tree-based methods and ensemble methods outperform the rest of the studied machine learning methods. Among the supervised algorithms, XGBoost ranks the first with 97% accuracy, 90.5% Matthews correlation coefficient (MCC), and 99.6% Area Under the Curve (AUC) performance. Moreover, a notable research finding of this study is that the Expectation-Maximization (EM) algorithm, which is an unsupervised method, also performs reasonably well in the detection of the attacks in the NSL-KDD dataset and outperforms the accuracy of the Naïve Bayes classifier by 22.0%.
Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populations

The natural history of tuberculosis (TB) is characterized by a large inter-individual outcome variability after exposure to Mycobacterium tuberculosis. Specifically, some highly exposed individuals remain resistant to M. tuberculosis infection, as inferred by tuberculin skin test (TST) or interferon-gamma release assays (IGRAs). We performed a genome-wide association study of resistance to M. tuberculosis infection in an endemic region of Southern Vietnam. We enrolled household contacts (HHC) of pulmonary TB cases and compared subjects who were negative for both TST and IGRA (n=185) with infected individuals (n=353) who were either positive for both TST and IGRA or had a diagnosis of TB. We found a genome-wide significant locus on chromosome 10q26.2 with a cluster of variants associated with strong protection against M. tuberculosis infection (OR=0.42, 95%CI 0.35-0.49, P = 3.71x10-8, for the genotyped variant rs17155120). The locus was replicated in a French multi-ethnic HHC cohort and a familial admixed cohort from a hyper-endemic area of South Africa, with an overall OR for rs17155120 estimated at 0.50 (95%CI 0.45-0.55, P = 1.26x10-9) . The variants are located in intronic regions and upstream of C10orf90, a tumor suppressor gene which encodes an ubiquitin ligase activating the transcription factor p53. In silico analysis showed that the protective alleles were associated with a decreased expression in monocytes of the nearby gene ADAM12 which could lead to an enhanced response of Th17 lymphocytes. Our results reveal a novel locus controlling resistance to M. tuberculosis infection across different populations.