Miracle-dz/UniFAR-FTUs huggingface dataset:
Enrolling patients into clinical trials faster using RealTime Recuiting

Previous work has been done on both optimizing the clinical trials process, and on sending critical laboratory results and decision support through paging systems. We report the first integration of both these solution, focusing on improving the clinical trial recruitment process. We describe a clinical trial needing a real-time method of recruiting patients in an unbiased manner, quickly enough that study tests can be obtained before patients leave or samples discarded. The report describes how the ten currently recruited patients were found and how diagnoses of potentially life-threatening disorders are being made.
Identification of the Valid Reference Genes for Quantitative RT-PCR in Annual Ryegrass (Lolium multiflorum) under Salt Stress

Annual ryegrass (Lolium multiflorum) is a cool-season annual grass cultivated worldwide for its high yield and quality. With the areas of saline soil increasing, investigation of the molecular mechanisms of annual ryegrass tolerance under salt stress has become a significant topic. qRT-PCR has been a predominant assay for determination of the gene expression, in which selecting a valid internal reference gene is a crucial step. The objective of present study was to evaluate and identify suitable reference genes for qRT-PCR in annual ryegrass under salt stress. The results calculated by RefFinder indicated that eEF1A(s) was the most stable reference gene in leaves, whereas EF1-a was the least stable; meanwhile, TBP-1 was the most optimal in roots and in all samples, and the eIF-5A shouldn’t be utilized for normalization of the gene expression. eEF1A(s) is more suitable than TBP-1 as reference gene in leaves when verified with P5CS1 and Cyt-Cu/Zn SOD genes. We should choose optimal reference genes in specific tissues instead of the most stable one selected from different conditions and tissues.
Characterisation of radio wave propagation in vehicular environments through deterministic methods

The interest for making vehicular transportation safer and more efficient has increased exponentially in recent years. To develop such vehicular communication systems, accurate models for the propagation channel are needed. This work analyzes the channel properties of different wireless communication systems within a vehicular communication environment with deterministic modeling. Three different frequencies have been analyzed: 868MHz, 2.4GHz and 5.9GHz. An in-house 3D Ray Launching code has been used for that purpose, taking into account the movement of the vehicles, leading to time and space-frequency models. Results present the great influence of multipath propagation in these type of environments, leading to a great aid in the identification of the optimal location of the transceivers, in order to minimize power consumption and increase overall service performance.
The Political Economy of Labor Cost Behavior: Evidence from China

China exhibits the highest degree of cost stickiness among the 20 economies surveyed by Banker and Byzalov (2014). We hypothesize that to maintain social stability Chinese government has the incentive and ability to avoid labor cut when firms’ sales decline, thus affecting the labor cost stickiness. We find that, consistent with our hypotheses, state owned enterprises (SOEs) have a higher degree of labor cost stickiness than non-SOEs, and SOEs with politically connected managers have stickier labor costs than those without. Such effects are stronger in regions with weak institutions and during time periods when government officials are to be promoted. We also show that the government reciprocates SOEs’ sticky labor policies with subsequent subsidies. In contrast, political forces have little impact on the stickiness of other costs, indicating that the impact of the government is the strongest on labor employment. Collectively, our results support the argument that political incentives shape firms’ labor employment decisions via ownership control and management political ties.
How does work management improve job satisfaction? Evidence from Spain

Our purpose is to analyze the influence of organizational and psycho-social practices on job satisfaction in Spain. Our hypothesis maintains that modern businesses organize work providing greater well-being for the worker, with the understanding that requiring a more cooperative attitude from the worker generates greater productivity. Using data from the Survey on the Quality of Life on the Job, 2004, we select the determinants of job satisfaction. Our findings indicate that work appears to have intrinsic value, and that the variables related to human relationships, particularly, those corresponding to social and work relationships, have an influence on job satisfaction.
The methodological quality of systematic reviews published in high-impact nursing journals: a review of the literature.

AIMS AND OBJECTIVES To analyse systematic review articles published in the top 10 nursing journals to determine the quality of the methods employed within them. BACKGROUND Systematic review is defined as a scientific research method that synthesises high-quality scientific knowledge on a given topic. The number of such reviews in nursing science has increased dramatically during recent years, but their methodological quality has not previously been assessed. DESIGN A review of the literature using a narrative approach. METHODS Ranked impact factor scores for nursing journals were obtained from the Journal Citation Report database of the Institute of Scientific Information (ISI Web of Knowledge). All issues from the years 2009 and 2010 of the top 10 ranked journals were included. CINAHL and MEDLINE databases were searched to locate studies using the search terms 'systematic review' and 'systematic literature review'. A total of 39 eligible studies were identified. Their methodological quality was evaluated through the specific criteria of quality assessment, description of synthesis and strengths and weaknesses reported in the included studies. RESULTS Most of the eligible systematic reviews included several different designs or types of quantitative study. The majority included a quality assessment, and a total of 17 different criteria were identified. The method of synthesis was mentioned in about half of the reviews, the most common being narrative synthesis. The weaknesses of reviews were discussed, while strengths were rarely highlighted. CONCLUSION The methodological quality of the systematic reviews examined varied considerably, although they were all published in nursing journals with a high-impact factor. RELEVANCE TO CLINICAL PRACTICE Despite the fact that systematic reviews are considered the most robust source of research evidence, they vary in methodological quality. This point is important to consider in clinical practice when applying the results to patient care.
Data Structures for Parsimony Correlation and Biosequence Co-Evolution

We give an algorithm for discovering co-evolution in biosequences from a dataset consisting of aligned data and a phylogeny. The method correlates vectors of parsimony scores on the edges of a graph, averaged over all optimally parsimonious reconstructions of the data. We describe an efficient data structure, and a preprocessing step that allows for rapid, interactive computation of many correlation scores, at the expense of storage space.
Advances in High-yield Cultivation of Peanut and High-yield Method for Peanut Planting in Southern China

Increasing total yield by raising unit yield of peanut is a sustainable and fundamental way to guarantee the supply of peanut.The status of unit yield level,high-yield record and yield potential of peanut in worldwide and china were introduced;the advances in high-yield peanut in China and abroad were reviewed from aspects of morphogenesis,physiochemical characteristics,natural conditions and culturing management;the reasons that caused deference in unit yield between the Southern China and the Northern China were analyzed;the method that further increasing yield for peanut planting in southern China and the restrict factors should be conquered were expounded.
Intravoxel Incoherent Motion Analysis of Abdominal Organs: Application of Simultaneous Multislice Acquisition

Purpose The aim of this study was to systematically evaluate the accuracy of quantitative intravoxel incoherent motion (IVIM) analysis of the upper abdomen applying simultaneous multislice (SMS) diffusion-weighted imaging (DWI) to reduce acquisition time. Materials and Methods Diffusion-weighted imaging of parenchymal abdominal organs was performed in 8 healthy volunteers at 3 T using a standard DWI sequence (acceleration factor 1 [AF1]) and an SMS-accelerated echo planar imaging sequence with acceleration factors 2 and 3 (AF2/AF3). Intravoxel incoherent motion analysis was performed with a multistep algorithm for true diffusion coefficient (Dt), pseudodiffusion coefficient (D*), and fraction of perfusion (Fp) measured for the liver, kidney cortex and medulla, pancreas, spleen, and erector spinae muscle. Qualitative and quantitative parameters were compared using a repeated measurement 1-way analysis of variance test and the Bonferroni post hoc method. Results Simultaneous multislice DWI provided diagnostic image quality in all volunteers with a reduction of scan time of 50% for AF2 (67% for AF3) compared with the standard sequence. Decent IVIM analysis for Dt, D*, and Fp can be calculated on the images of both the SMS sequences AF2 and AF3 with typical organ characteristics of IVIM; however, systematical deviations from AF1 were observed: Dt values increased and Fp decreased significantly with higher acceleration factor for liver, kidney, pancreas, and muscle (P < 0.05). Fitting curves of higher acceleration factors tend to be more monoexponentially shaped. Conclusions Simultaneous multislice acceleration provides considerable scan time reduction for upper abdomen DWI with equivalent quality of IVIM analysis compared with the standard nonaccelerated technique. Systematic discrepancies of the true Dt, D*, and Fp for SMS acquisitions need to be considered when comparing to standard DWI sequences.
Dynamics Adjustment of Capital Structure under Macroeconomic Impact——A Differential Analysis Based on Financial Constraints

With a sample of manufacturing listed companies from 1998 to 2009,the paper researches the impacts of macroeconomic shocks on the direction and speed of capital structure dynamics adjustment of the companies at different financial constraints level.The results show that both macroeconomic shocks and financial characteristics influence the dynamics adjustment of capital structure.Financial constrained companies are more frangible in the macroeconomic shocks,they can't obtain the external financing in the recession and their leverage is counter-cyclical,they fail to concern the cost of capital as a result of the over-dependent on the external finance,so their speed of capital structure dynamics adjustment will be slow in the shocks of macroeconomic condition.
Fault Location Using Sparse Synchrophasor Measurement of Electromechanical-Wave Oscillations

This paper presents a novel system-wide fault-location method for transmission lines utilizing electromechanical-wave oscillation propagation phenomena. The method uses synchrophasor measurements during disturbances obtained from phasor measurement units sparsely located in the network. The method determines the time of arrival of electromechanical waves propagating from the fault point to sparsely located phasor measurement units. By taking the speed of electromechanical-wave propagation as well as topology of the network into account, the method is able to detect the faulty line. Finally, by adding fictitious buses inside the faulty line and applying a binary search method, the location of fault is accurately pinpointed. The main advantage of the proposed method is the use of a limited number of PMUs which reduces the cost of implementation. The method was developed in MATLAB and tested with the IEEE 118-test system. Test results reveal the high accuracy of the method in detecting and locating faults.
Stability of membrane proteins: relevance for the selection of appropriate methods for high-resolution structure determinations.

High stability is a prominent characteristic of integral membrane proteins of known atomic structure. But rather than being an intrinsic property, it may be due to a selection exerted by biochemical procedures prior to structure determination, since solubilization results in the transient exposure of membrane proteins to solution conditions. This may cause structural perturbations that interfere with 3D crystallization and hence with X-ray analysis. This problem also affects the preparation of samples for electron crystallography and NMR studies and may account for the fact that high-resolution structures of representatives of whole groups, such as transport proteins and signal transducers, have not been elucidated so far by any method. A knowledge of the proportion of labile proteins among membrane proteins, and of the kinetics of their denaturation, is therefore necessary. Establishing stability profiles, developing methods to maintain lateral pressure, or preventing contact with water (or both) should prove significant in establishing the structures of conformationally flexible proteins.
Radio-visual signal fusion for localization in cellular networks

Location based services in wireless networks is a quite demanding application especially in urban areas. Cellular network provides measurements regarding the signal attenuations from serving and neighbouring base stations for managing radio resources. Localization based on this inconsistent received signal strength is a challenging problem. This paper describes a novel bimodal localization idea for mobile users in cellular networks. A series of vision-based algorithms are applied to extract user position from monocular vision and then augment it with extracted location in cellular network. A probabilistic framework based on particle filters developed to fuse the bimodal data as well as localize the mobile user from inconsistent measurements. An adaptive particle weighting scheme based on the modal confidence coefficient is also developed. This approach can be easily implemented to utilize available online visual databases to increase accuracy of conventional localization methods for wireless networks even in indoor environments that other navigation signals are not available.
Orai1‐induced store‐operated Ca2+ entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine platelets

Orai1, the major store‐operated Ca2+ entry (SOCE) channel in platelets, is not only critical for enhancing diverse signaling pathways, but may also regulate receptor‐operated Ca2+ entry (ROCE). Dynamic coupling of the Orai1 signalosome to canonical transient receptor potential channels (TRPCs) has been suggested as an essential step in the activation of SOCE and ROCE. However, the functional significance of the biochemical interaction between Orai and TRPC isoforms remains controversial.
Exploring residential satisfaction in shrinking cities: a decision-tree approach

The number of cities experiencing population decline has been increasing worldwide. Despite the existence of theoretical propositions of shrinkage as an opportunity to increase levels of residential satisfaction, the issue has not been addressed empirically. This article contributes to fill this gap by assessing, through survey, the residential satisfaction of inhabitants of four shrinking Portuguese cities. Data were analysed by means of a tree-decision approach: the Chi-squared Automatic Interaction Detection analysis. A sense of safety is the feature that best discriminates inhabitants’ level of residential satisfaction. The results show that shrinkage due to deindustrialisation processes is detrimental to residential satisfaction.
An interprofessional team approach to fall prevention for older home care clients ‘at risk’ of falling: health care providers share their experiences

Background Providing care for older home care clients ‘at risk’ of falling requires the services of many health care providers due to predisposing chronic, complex conditions. One strategy to ensure that quality care is delivered is described in the integrated care literature; interprofessional collaboration. Engaging in an interprofessional team approach to fall prevention for this group of clients seems to make sense. However, whether or not this approach is feasible and realistic is not well described in the literature. As well, little is known about how teams function in the community when an interprofessional approach is engaged in. The barriers and facilitators of such an approach are also not known. Purpose The purpose of this qualitative study was to describe the experiences of five different health care professionals as they participated in an interprofessional team approach to care for the frail older adult living at home and at risk of falling. Methodology This study took place in Hamilton, ON, Canada and was part of a randomized controlled trial, the aim of which was to determine the effects and costs of a multifactorial and interdisciplinary team approach to fall prevention for older home care clients ‘at risk’ of falling. The current study utilized an exploratory descriptive design to answer the following research questions: how do interprofessional teams describe their experiences when involved in a research intervention requiring collaboration for a 9-month period of time? What are the barriers and facilitators to teamwork? Four focus groups were conducted with the care-provider teams (n=9) 6 and 9 months following group formation. Results This study revealed several themes which included, team capacity, practitioner competencies, perceived outcomes, support and time. Overall, care providers were positive about their experiences and felt that through an interprofessional approach benefits could be experienced by both the provider and the patient and his/her family. Findings from this study suggest that research needs to be conducted to further explore the issues faced by this group of care providers and potential client outcomes.
Molecular Cloning and Characterization of a Novel Type of Histamine Receptor Preferentially Expressed in Leukocytes*

Recently cDNA encoding the histamine H3 receptor was isolated after 15 years of considerable research. However, several studies have proposed heterogeneity of the H3 receptor. We report here the molecular cloning and characterization of a novel type of histamine receptor. A novel orphan G-protein-coupled receptor named GPRv53 was obtained through a search of the human genomic DNA data base and analyzed by rapid amplification of cDNA ends (RACE). GPRv53 possessed the features of biologic amine receptors and had the highest homology with H3 receptor among known G-protein-coupled receptors. Mammalian cells expressing GPRv53 were demonstrated to bind and respond to histamine in a concentration-dependent manner. In functional assays, not only an H3 receptor agonist,R-(α)-methylhistamine, but also a H3 receptor antagonist, clobenpropit, and a neuroleptic, clozapine, activated GPRv53-expressing cells. Tissue distribution analysis revealed that expression of GPRv53 is localized in the peripheral blood leukocytes, spleen, thymus, and colon, which was totally different from the H3 receptor, whose expression was restricted to the brain. The discovery of the GPRv53 receptor will open a new phase of research on the physiological role of histamine.
Memory for Routes

Two experiments examined the acquisition of cognitive maps of two intersecting routes through an urban area. In the presentation stage of the experiments, slides of the two routes were shown in order to simulate travel along the routes. The number of presentations of the slides was varied. In the test stage, subjects made directional and distance judgements from memory between places on the routes. The results suggest that from the start of acquisition of the spatial layout of the routes, subjects used network schemata in which both routes were combined, rather than a separate scheme for each route which were later combined. During initial acquisitions of the routes, a direction of travel bias was found such that spatial judgements from memory tended to be more accurate in the direction of travel along the routes than in the opposite direction. The findings imply that, at least during early acquisition, the spatial properties of the routes were encoded in terms of sequential associations.
The role of EphB4 and IGF-IR expression in breast cancer cells.

OBJECTIVE to investigate the role of EphB4 and IGF-1R in the proliferation and migration of breast cancer. METHODS The relative mRNA levels of EphB4 were measured by RT-PCR. The proliferation of the cells was determined by MTT assay, and cells migration and invasive ability was analyzed using the scratch migration assay. RESULTS The expression of EphB4 in control group was significantly decreased when compared with IGF-I group (P<0.001). The expression of EphB4 in IGF-I+LY and LY group were lower than that of the control group (P<0.001). The cell proliferation and migration ability of the cells in IGF-I group increased significantly compared to the cells in the control group (P<0.001), while the cells in IGF-1+LY group and LY group showed a decreased proliferation and migration ability compared to the control group (P<0.001). CONCLUSION IGF-IR might be a upstream gene of EphB4. Besides, higher expression of EphB4 shows increased tumor proliferation and migration in breast cells. The study of EphB4 upstream gene and signaling pathway can provide more targeted anti-tumor point selection for targeted therapy.
Integrative systems and synthetic biology of cell-matrix adhesion sites

ABSTRACT The complexity of cell-matrix adhesion convolves its roles in the development and functioning of multicellular organisms and their evolutionary tinkering. Cell-matrix adhesion is mediated by sites along the plasma membrane that anchor the actin cytoskeleton to the matrix via a large number of proteins, collectively called the integrin adhesome. Fundamental challenges for understanding how cell-matrix adhesion sites assemble and function arise from their multi-functionality, rapid dynamics, large number of components and molecular diversity. Systems biology faces these challenges in its strive to understand how the integrin adhesome gives rise to functional adhesion sites. Synthetic biology enables engineering intracellular modules and circuits with properties of interest. In this review I discuss some of the fundamental questions in systems biology of cell-matrix adhesion and how synthetic biology can help addressing them.
Overcoming the liability of outsidership in institutional voids: Trust, emerging goals, and learning about opportunities

Building on the complementarity of the revisited Uppsala model and effectual logic, this article examines the role of affective and cognitive trust for developing knowledge in the context of small- and medium-sized enterprise (SME) internationalization in emerging markets. Drawing on qualitative interview data from New Zealand SMEs engaging with Chinese business partners, the article first shows that an overreliance on affective trust can result in a situation of ‘persistent mediation’, in which learning about opportunities is impaired. Second, utilization of the affordable loss principle and a focus on control facilitates relationship-specific knowledge, which may also lead to cognitive trust. However, cognitive trust does not necessarily transform in the substantive business market knowledge needed to overcome the liability of outsidership. Third, business market knowledge is advanced when partners mutually set goals and develop the opportunity, which potentially also fosters cognitive and affective trust.