Miracle-dz/UniFAR-FTUs huggingface dataset:
Non-invasive predictors & clinical outcomes of Non ST Elevation myocardial infarction (NSTEMI) with completely occluded coronary artery (OCA)

Mesbah Taha Hassanein, Mohamad Mostafa El daydamony, Marwa Mohamed Gad and Mohamed Hosny Ibrahim Badawy 1 Faculty of Medicine, Zagazig University, Department of Cardiology, Sharkia Egypt 2 Faculty of Medicine, Zagazig University, Department of Cardiology, Sharkia Egypt 3 Faculty of Medicine, Zagazig University, Department of Cardiology, Sharkia Egypt 4 Faculty of Medicine, Zagazig University, Department of Cardiology, Sharkia Egypt
Solid commitment to maternal and child health initiatives has yielded infant mortality rates matching those of higher-income countries.

Latin America, and especially Chile, has done well in reducing infant mortality, with rates of around twenty-five per thousand live births. There are two clear phases of de- clining mortality: one largely influenced by poverty reduction, primary health care, and envi- ronmental and demographic factors; and a second one more sensitive to focused health care interventions. In 2000 Chile reached 8.9 infant deaths per 1,000, using interventions that represent an increase in the provision of services related to perinatal risks, acute respi- ratory diseases, congenital heart conditions, and certain vaccine-preventable infections. Chile, with per capita income near U.S.$5,000 in 2000, has infant mortality that compares with that of wealthier countries. (Health Affairs 26, no. 2 (2007): 458-465; 10.1377/ hlthaff.26. 2.458)
Adicción en pacientes con dolor crónico

Los opioides son la piedra angular en el tratamiento del dolor cronico de intensidad moderada a elevada, pero por su mecanismo de accion presentan ciertas particularidades que los hacen farmacos de riesgo. Solo una minoria de pacientes con dolor cronico esta en alto riesgo de desarrollar problemas de adicciones, considerando a la poblacion entera de pacientes con dolor. De acuerdo a sus propiedades farmacologicas, los opioides presentan una afectacion directa o indirecta a una via nerviosa presente en el cerebro, que es el sistema de recompensa mesolimbico, lo cual los clasifica como farmacos de riesgo para adicciones. Pero en el paciente con dolor, sin un antecedente claro de abuso de otras sustancias desde tabaco, alcohol o cualquier droga, no hay riesgo para desencadenar una adiccion durante su uso medico
P4679Changes in systemic inflammation and endothelial dysfunction after balloon pulmonary angioplasty

Pulmonary endarterectomy leads to a decrease in systemic inflammation and improvement in endothelial function in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Balloon pulmonary angioplasty (BPA) improves pulmonary hemodynamics in patients with inoperable CTEPH. To assess changes in systemic inflammation and endothelial dysfunction after a single BPA session and after completion of the treatment. We enrolled consecutive, inoperable CTEPH patients who underwent BPA. Interleukin 6, 10 (IL-6, IL-10), and C-reactive protein (hsCRP) constituted markers of systemic inflammation. Endothelin-1 (ET-1) served as a marker of endothelial dysfunction. Serum concentration of selected markers was assessed in every patient before, 24 hours after the first BPA session and 6 months after completion of the BPA treatment. Age- and sex-matched healthy subjects served as a control group. We recruited 20 patients with inoperable CTEPH (6 males [30%]), aged 67 [61–74] years in New York Heart Association class III (n=19 [95%]) and II (n=1 [5%]). BPA treatment was completed with a median of 5 [2–8] BPA sessions per patient. Before starting the treatment CTEPH patients, as compared to controls (n=10), had raised serum level of IL-6 (3.82 [2.75 - 6.03] vs. 2.64 [0.88 - 4.75] pg/ml; p=0.04), hsCRP (2.47 [0.93 - 4.27] vs. 1.23 [0.48–3.21] ng/ml; p=0.02) and ET-1 (2.68 [2.24 - 3.64] vs. 1.47 [1.4 - 1.82] pg/ml; p=0.004). There was no difference in IL-10 level. 24 hours after a BPA session we observed an increased level of IL-6, IL-10 and hsCRP. (Tab.) 6 months after completion of the BPA treatment there was a reduced level of IL-6, hsCRP and ET-1 (Tab.) Table 1. Changes (Δ) in serum concentration of analyzed markers 24 hours after a single BPA session and at 6-months assessment after completion of the BPA treatment (n=20) Initial Δ at 24 hours after single BPA p Δ at 6-months follow-up p ET-1 [pg/ml] 2.68 [2.24; 3.64] −0.2 [−0.5; 0.23] 0.21 −0.47 [−0.96; 0.05] 0.004 IL-6 [pg/ml] 3.82 [2.75; 6.03] 3.67 [1.41; 7.16] 0.008 −0.82 [−3.11; 0.54] 0.04 IL-10 [pg/ml] 0.53 [0.44; 0.58] 0.32 [0.21; 0.87] 0.006 −0.11 [−0.33; 0.14] 0.94 hsCRP [ng/ml] 2.47 [0.93; 4.27] 5.4 [3.96; 10.59] 0.008 −0.36 [−0.94; 0.16] 0.02 ET-1, endothelin 1; hsCRP, C-reactive protein; IL-6, interleukin 6; IL-10, interleukin 10. Patients with inoperable CTEPH, as compared to healthy controls, exhibit an increased systemic inflammation and endothelial dysfunction, which both improve after completion of the BPA treatment. At short-term follow-up after single BPA session there is an increase in systemic inflammatory response.
Pregnancy Outcomes in Women Aged 40 Years and Older

Objective: The aim of this study was to compare the pregnancy outcomes in women aged 40 years and older to that of women 20 to 29 years old after 20 weeks of gestation. Materials and Methods: In this cross-sectional retrospective study, 153 pregnant women at least 40 years of age consisted the study group while 156 pregnant women aged between 20 and 29 years consisting the control group. The relation between maternal age and pregnancy outcomes was analysed with contingency χ 2 or two-tailed Fisher’s exact test with adjusted odds ratios according to age group. Results: Multiparity and pre-existing chronic medical diseases were observed more frequently in the study group. Older gravidas were more likely to develop gestational diabetes (OR: 15.6, 95% CI: 2.0-120.3) and preeclampsia (OR: 3.9, 95% CI: 1.9-8.0). Older women were also at increased risk for cesarean delivery (OR: 2.3, 95% CI: 1.4-3.7). Rates of delivery before 34 weeks (OR: 4.1, 95% CI: 1.3-12.8) and before 37 weeks (OR: 3.0, 95% CI: 1.2-7.4) were also observed significantly higher in the study group. Low birth weight (<2500 g) was more prevalent in the study group (OR: 11.6, 95% CI: 2.7-50.5). There was not any significant difference between groups in terms of mean birth weight, very low birth weight (<1500 g), intrauterine growth restriction and stillbirth. Conclusion: Pregnant women aged ≥40 years are at increased risk of complications in pregnancy when compared to younger women. More intensive antenatal follow up is necessary for older gravidas.
The comparison of the effect of traditional and off-line electronic educational methods on the knowledge and attitude of the undergraduate dental students of Shiraz University of Medical Sciences

Introduction: E-learning as one of the new methods of learning makes it possible to achieve skills at higher levels without time and space constraints. The purpose of this research was to compare the effect of case-based learning in two ways of personal and off-line (forum) E-learning on the knowledge and attitudes of undergraduate medical students of Shiraz University of Medical Sciences.Methods: This is a semi-experimental research, which was conducted on 44 dental students in the academic year of 2014. Sampling was a block randomizing. Both groups were given written exams before and after teaching in order to evaluate the participants’ awareness and knowledge of the content, the satisfaction level and attitudes of both groups were questioned by the application of an exam following the Likert scale format of 1-5. In this study, a paired samples t-test was used for comparing students’ pretest and posttest scores in each group, and an independent samples t-test was run for comparing the changes in scores, students’ attitudes, and satisfaction in both groups. In case of derivation from the normal distribution hypothesis, non-parametric equivalents were used in these tests. The acceptable significant level was α=0.05. Results: The mean score of primary awareness in both groups of personal and E-learning was statistically the same (p=0.647). A significant increase was observed in the awareness level of people after the application of learning (p < 0.001). The awareness of people in personal and E-learning groups before learning (median=2) was significantly increased compared to that after learning (personal: median=5 and electronic: median=6). The increase of awareness in personal and E-learning groups was statistically the same (p=0.216). Generally, the increase of awareness level was similar in women and men (p=0.822). There was not a significant relationship between people’s attitude with the learning method and age of the participants. Conclusion: Given that the learning and attitudes of students in off-line (forum) E-learning and personal learning was the same, and regarding the effectiveness of E-learning in time reduction and saving of costs and educational facilities, this new method can be used as a part of learning activities in medical learning program.
IMONOGLOBIN-E IN TYPE II DIABETES AND ITS RESPONSE TO SINGLE BOUT EXERCISE TEST

In present study, we aimed to compare serum IgE between obese men with and without diabetes. We also aimed to evaluate acute response of IgE to single bout exercise in diabetes subjects. For this purpose, fasting serum IgE was measured in untrained adult obese men with (n=14) and without (n=14) type II diabetes. Serum IgE was also measured immediately after short time single bout cycling in patients group. Independent T test used to compare serum IgE between two groups and paired sample T test for determine changes between pre and post exercise in patients. Serum IgE levels were significantly higher in patients in comparison to healthy subjects (p = 0.022). Fasting glucose concentrations and insulin resistance were also higher in diabetic than in healthy subjects (P <0.05). Compared to pre-exercise, serum IgE did non change by exercise test in patients (p = 0.783). These results demonstrate that acute bout cycling with a moderate-intensity is associated with increase serum level of IgE in diabetic individuals.
Pathophysiology of Heat Stroke

Abstract Download Free Sample Heat illnesses exist along a continuum starting with the mild condition of heat exhaustion and progressing to heat injury and heat stroke. Heat stroke is a life-threatening condition clinically characterized by a severe elevation in body temperature with central nervous system dysfunction that often includes combativeness, delirium, seizures, and coma. Classic heat stroke is experienced primarily by the very young or elderly during annual heat waves. Exertional heat stroke is a condition experienced by young, fit individuals during strenuous physical activity in hot or temperate environments. Heat stroke sequelae are a consequence of heat injury to the tissues in combination with coagulopathies and a systemic inflammatory response syndrome (SIRS) that often culminates in multi-organ system dysfunction or death. Endotoxin leakage across ischemic-damaged gut membranes is thought to initiate the SIRS with cytokines and other inflammatory mediators involved in this multi-factoria.
A REVIEW ON MEDICINAL PLANTS EXHIBITING ANTIFERTILITY ACTIVITY

Although contraceptives containing estrogen and progesterone are effective and popular used for family planning, but due to serious adverse effects produced by synthetic steroidal contraceptives such as toxicity to gonads, Infertility on temporary or permanent basis, testicular germ cell cancer, breast/ Prostate cancer, brain developmental problems, endometriosis and early puberty etc, the risks associated to the drugs have triggered the need to develop newer molecules from medicinal plants. Hence, there is a need for searching suitable product from medicinal plants that could be effectively used in the place of pills for antifertility activity. The nature has been a source of medicinal agents for thousands of years and an impressive number of modern drugs have been isolated from natural sources. Plants are used as anti-implantation, abortifacient and as contraceptive are well known to the ancient physicians of India. Various medicinal plant extracts have been tested for their antifertility activity both in male and female animal models activity and the active agents. This review presents updated information gathered on medicinal plants used for anti-fertility activity in both male and females. The aim of this review is to highlight the work on anti-fertility of
Increased Risk of Infection in Bereaved Older Adults: From Broken Heart to Broken Immune System

Bereavement, the loss of someone close, is frequently followed by grief and can have serious implications for physical and mental health, from the increased symptoms of depression and anxiety, sleep disturbances and indigestion, and more serious physical health consequences such as cardiovascular and immune related illness. Another key factor associated with a deterioration of the body’s defence mechanisms, such as the immune system, is ageing. This review has as its focus the combined effects of bereavement and ageing on immune function. First, the relationship between bereavement and increased mortality is examined, followed by its link to various physical and mental health morbidities. Second, the effects of ageing per se on immune functions are considered. Finally, the joint impact of both ageing and bereavement are discussed, focussing on recent studies of immune function after bereavement in young and older adults.
Gender differences in stress intensity and coping strategies among students, future emergency relief specialists

Background/Aim. Assisting students face high academic demands which, together with interpersonal, intrapersonal and professional requirements, can be a significant source of stress. The aim of the study was to examine the intensity and frequency of the source of stress, coping strategies and identify gender differences among students, future assisting professionals. Methods. An observational, cross-sectional study was conducted amongst the students of the University of the Belgrade Faculty of Security (Serbia) who, after graduation, will acquire the title of a security manager responsible for human resources in the civil sector. The data were collected in the period October-November 2018. The authorized questionnaire SSM-30 by Jovic (Stress scale for the young ? 30) was used, which enables students to assess the stress situations intensity on a scale from 1 (minimum) to 10 (maximum intensity). The SSM-30 questionnaire is a combination of the standard Life Events Scale ? Holmes Rashe Life Events Scale, also known as the Social Readjustment Rating Scale and life events characteristic for the student population. The questionnaire also included the sample demographic characteristics ? gender, and a year of study. The SSM-30 scale includes a list of stressful events and stress coping mechanisms shown in the results. Results. The most common sources of stress in both genders were social and academic ones: death in the family, critical illness in the family, an accident of a person they care about, unwanted pregnancy, lies from close people, disagreement with parents, loss of a study year, crisis, uncertainty after graduation and partner? s infidelity. The most frequently used mechanisms for controlling and overcoming stress were mostly social: talking with friends, listening to music, family support, frequent walks, socializing and going out, using the Internet, frequent sleep, intense physical activity, crying and relaxation. Statistically significant differences between the genders were confirmed ? female students demonstrated self-worth of higher intensity during the majority of stressful situations, as they use different stress coping mechanisms from their male students. Conclusion. The results obtained with regard to the assessment of stressors and the use of specific mechanisms for coping point to the need of additional education of students in this field in order to be more focused and open for free professional help, when necessary.
A comparison study on the Effects of Oak Extract, Hyper Perforatum, and silver sulfadiazine 1% on the second grade burn wounds in male

Burn is one of the major causes of mortality in the world, and its prevalence in the developing countries is multiple times the developed countries.In traditional medicinal plants were used to treat injuries and subside pains and accelerate the healing of burn wounds.Oak (Jaft) and Hypericum Perforatum as antioxidants have antimicrobial and antiseptic effects, the extracts of which were used in this design to repair second grade burns in male rats.Materials and methods: Some 50 male rats of wistar race with a weight of 200-250 grams were purchased, and were kept in the nest for one week for adaptation, with open (free) access to water, food, and appropriate ventilation, then the rats were divided randomly in five groups. The first group, burn control which were washed daily with physiology serum. The second, third, fourth, and fifth groups were treated after burn with Oak (Jaft) extract, Hypericum Perforatum, a mixture of Oak (Jaft) and Hypericum Perforatum, and silver- sulfadiazine ointment 1% respectively to create second grade burn, the animals were anesthetized with sodium thiopental (40 mg/kg/IP) and were exposed to boiling water in the arranged containers with a hole of 2 square centimeters area for 10 seconds so that the shaved surface of skin was in contact with the boiling water.After 35 days of treatment and after weighing the rats were anesthetized with Sodium thiopental. The specimen of the skin tissue of the injured area were taken and transferred to Formalin 10% solution.After tissue processing, the specimen were moulded, sections of 5 micron were prepared and staining was done with hematoxylin - eosin. Then, the tissue changes were studied using light microscope, and the obtaineddata were analyzed using SPSS software and unilateral variance analysis test.Results: The resultsdon't show statistical difference is in the average burn surface, thickness of epiderm and the rate of malondialdehyde in Oak extract, Hypericum Perforatum and the combination of these two, in comparison to other groups (P<0.05). Conclusion: It is probable that Oak extract and Hypericum Perforatum with their antioxidant properties are able to fortify each other's effects, with more appropriate dosages and repair the injuries of skin and its appends.
Effectiveness of an instructional video for diagnostic sputum production and tuberculosis case detection in Mwananyamala and Temeke hospitals in Dar es Salaam, Tanzania.

Introduction Tuberculosis (TB) is second only to HIV as an infectious cause to adult death. The disease remains to be a major global health problem whichin 2012 it is estimated that 8.6 million people developed TB and 1.3 million people died from TB worldwide. Sputum smear microscopy remains to be a cornerstone of diagnostic algorithm for TB diagnosis in lowincome settings like Tanzania. For diagnosis, presumptive TB cases with coughing for more than two weeks are asked to produce sputum spontaneously from the lungs. However, some cases are missed or given wrong treatmentdue to patients often giving only saliva from the mouth, which reduces the sensitivity of sputum smears. Methods An interventional study was conducted in Mwanayamala and Temeke hospitals in Dar es Salaam to assess the effectiveness of the video instruction on sputum production and submission for TB case detection. A total of 200 presumptive TB cases were recruited and divided into intervention and control groups. Intervention group received instructions on how to produce sputum by the use of the video prior to sputum collection and control group was instructed to follow routine standard care for sputum production without the use of the video. Results A significant difference was observed on TB case detection among intervention and control groups. TB detection was more on intervention group by (56%) more than control group which was 23% (p<0.05). Quality of sputum was observed to be significantly difference between the intervention and the control groups (p-value; 0.01). Conclusion Instructional provision for sputum production to TB patients hasbeen seen to yield positive results to production of good quality sputum for detection of TB as well as increasing the rate of acid fast bacillidetection among presumptive TB cases when video tools are incorporated into the instructions.
A study on relation of TSH (Thyroid stimulating hormone) levels in smokers and non-smokers- prospective study

Background: The effect of smoking on thyroid is believed to be due to the compound thiocyanate, a potent inhibitor of iodide transport, potentially capable of affecting the thyroid function. TSH is the major regulator of the morphologic and functional states of the thyroid. All steps in the formation and release of thyroid hormones are stimulated by TSH secreted by the pituitary thyrotrophs. These include both pro(e.g. thyroid stimulating) and anti-thyroid actions and also actions that increase susceptibility to or exacerbation of the manifestations of Graves’ disease. Thus, this study may be instrumental in early detection and management of thyroid disease in smokers. The aim of this study is to evaluate and compare TSH thyroid stimulating hormones status in smokers and non smokers. Methods: A prospective study is done with 60 patients divided into 2 groups. Group 1 (healthy male non-smokers) as control and Group 2 (healthy male smokers). Fasting blood samples were collected and serum TSH levels were estimated. The data was analyzed using unpaired t test. Results: In the present study significant decrease in TSH observed in the cases compared to the controls. Mean±S.D of TSH in Group 1 is 2.80±0.83 and Group 2 is 1.00±1.02, there is a significant decrease in serum TSH levels in Group 2. Interpretations & Conclusion: The finding in this study indicates that smoking is associated with biochemical hyperthyroidism. Hence evaluating thyroid hormone status in smokers might help in identifying occurrence of thyroid disorders and appropriate measures could be taken to prevent severity of morbidity and mortality associated with smoking.
Campylobacter bacteremia: A case report

Campylobacter bacteremia is rarely encountered, probably due to the fastidious nature of the organism. Moreover, it could be transient in nature, especially in immunocompetent individuals, but life-threatening in immunocompromised patients. We report a case of probable transient bacteremia in a recently diagnosed case Cirrhosis of Liver due to Autoimmune hepatitis with Primary Sclerosing Cholangitis.
Effect of Zincum metallicum and LPS treatments on femoral bone density in pregnant mice

Background: The simulated bacterial infection is a classical experimental model, by the injection of purified gram negative bacteria wall lipopolysaccharide (LPS) which produces effects similar to real infection, but without presence of the microorganism. The LPS is a stress factor as during the pregnancy and delivery, and pilot experiments have shown that ultra-high dilutions (UHD) may have a beneficial role in reducing the LPS stress. Zincum metallicum (Zm) has a potential to influence several physiological aspects of a living organism. It was chosen by a team of researchers from GIRI, to explore the effect of Zm on various experimental model (Zincum project). The optical density is a radiographic method for the measurement of the amount of hard bone tissue, and is an accessible, simple and non-invasive method. It is hypothesized that UHD Zm may influence the Zinc metabolism, therefore, bone tissues were collected to evaluate the zinc concentration.