Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation of multidimensional scaling-based modeling of alcohol expectancies in memory: age and drinking-related differences in expectancies of children assessed as first associates.

BACKGROUND As evidence has accumulated that alcohol expectancies mediate the effects of other drinking antecedents, attempts to understand the mechanism by which expectancies influence behavior have focused on modeling memory processes. Previous expectancy work, however, has used relatively indirect approaches to retrieve and model information stored in memory. By using the method most recommended by memory researchers for directly obtaining uncontaminated memory contents, we assessed children's expectancies and related findings to empirically modeled organization and activation of expectancies in memory based on scaled instruments. METHODS Individual interviews were conducted with 462 children in 2nd through 5th grades, and surveys were completed by 1,003 children in 3rd, 6th, 9th, and 12th grades. Interviews and surveys consisted of a measure designed to retrieve participants' first expectancy associate to an alcohol prompt and several drinking quantity/frequency questions. RESULTS Older and higher drinking children were more likely to report positive expectancies as their first associate to an alcohol prompt. Age and drinking-based findings were consistent with organizational structure, dimension emphasis shift, and paths of association identified by prior multidimensional scaling techniques. CONCLUSIONS Consumption of alcohol among children corresponded to accessibility of positive expectancies in memory. In addition, the use of multidimensional scaling to study the organization and activation of alcohol expectancies in memory was validated.
Two cases of immune haemolytic anaemia, associated with anti‐piperacillin, detected by the ‘immune complex’ method

Background and Objectives Sera containing antibodies to penicillin and penicillin‐related drugs are typically thought to react with drug‐coated red blood cells (RBCs) (drug adsorption method), but not when the sera are added to drug and RBCs in the same tube (‘immune complex’ method). Two cases of immune haemolytic anaemia caused by anti‐piperacillin have been previously described. Serological details were given in only one patient. In that subject, the antibody was immunoglobulin (Ig)M + IgG and reacted by both the drug adsorption and ‘immune complex’ methods.
An Analytical Study for Early Diagnosis and Treatment of Infants & Children Suffering From Congenital Hypothyroidism in China

Objective: To study the clinical and laboratory characteristics of children suffering from congenital hypothyroidism in China. Method: 455 cases of congenital hypothyroidism infants were collected from 5 articles were published in 4 china medical journals. Different screening methods were adopted, like enzyme immunoassay assay and filter paper dried blood biotin-avidin enzyme notation to test TSH, FT3、FT. All the collected children treated by oral thyroxin tablets for long period and regular follow-up was done. Clinical follow up for any signs of hypothyroidism and also detection of I.Q of those children.
Localization of endocardial ectopic activity by means of noninvasive endocardial surface current density reconstruction

Localization of the source of cardiac ectopic activity has direct clinical benefits for determining the location of the corresponding ectopic focus. In this study, a recently developed current-density (CD)-based localization approach was experimentally evaluated in noninvasively localizing the origin of the cardiac ectopic activity from body-surface potential maps (BSPMs) in a well-controlled experimental setting. The cardiac ectopic activities were induced in four well-controlled intact pigs by single-site pacing at various sites within the left ventricle (LV). In each pacing study, the origin of the induced ectopic activity was localized by reconstructing the CD distribution on the endocardial surface of the LV from the measured BSPMs and compared with the estimated single moving dipole (SMD) solution and precise pacing site (PS). Over the 60 analyzed beats corresponding to ten pacing sites (six for each), the mean and standard deviation of the distance between the locations of maximum CD value and the corresponding PSs were 16.9 mm and 4.6 mm, respectively. In comparison, the averaged distance between the SMD locations and the corresponding PSs was slightly larger (18.4 ± 3.4 mm). The obtained CD distribution of activated sources extending from the stimulus site also showed high consistency with the endocardial potential maps estimated by a minimally invasive endocardial mapping system. The present experimental results suggest that the CD method is able to locate the approximate site of the origin of a cardiac ectopic activity, and that the distribution of the CD can portray the propagation of early activation of an ectopic beat.
Integrated routing resource assignment for RLC crosstalk minimization

The paper deals with the crosstalk problem for DSM designs in an integrated routing resource assignment stage containing the various operations between global routing and detailed routing. The heuristic proposed for minimizing RLC crosstalk noise is in two-stages: the coarse assignment problem with shield planning is formulated as a max-k-cut of the coarse coupling graph, and solved with SDP; in detailed assignment, a dynamic priority queue is employed to ensure that each segment is assigned properly. Experimental results corroborate the effectiveness and efficiency of the algorithm.
Radiation increases fibrogenic cytokine expression by Peyronie's disease fibroblasts.

PURPOSE Peyronie's disease is a crippling penile deformity that results from fibrosis in the tunica albuginea. To our knowledge its cause is unknown and empirical therapies are used extensively. A factor involved in the development of Peyronie's disease is fibrogenic cytokine over expression. Radiation therapy is an empirical therapy for this condition and, while some data suggest a role for it, no literature exists on the effects of radiation on tunical tissue or cells derived from this tissue. We evaluated the effect of radiation on fibrogenic cytokine production in cells cultured from Peyronie's disease plaque tissue. METHODS AND MATERIALS Using a well established cell culture model cells derived from Peyronie's disease plaque tissue and neonatal foreskins were irradiated with 5 Gy (treatment group) or left nonirradiated (control group). At 24 hours cells were harvested and the supernatant was analyzed using enzyme-linked immunosorbent assay to determine the levels of the 2 fibrogenic cytokines basic fibroblast growth factor and platelet-derived growth factor-AB. RESULTS Four Peyronie's disease plaque derived cultures and 2 neonatal foreskin derived cultures were analyzed. All plaque derived fibroblasts demonstrated significant elevations in basic fibroblast growth factor and platelet-derived growth factor-AB compared with foreskin derived fibroblasts. CONCLUSIONS These data suggest that radiation may in fact increase the production of fibrogenic cytokines, which may promote the fibrotic process involved in Peyronie's disease. Further study is aimed at defining the effect of irradiation on plaque tissue.
Evidence of multifocal activity of coronary disease in patients with acute myocardial infarction.

BACKGROUND Destabilization of the fibrous cap facilitates plaque rupture, thrombus formation, and myocardial infarction. Because systemic stimuli, such as lipoproteins, infectious agents, and autoantigens, may incite this reaction, one may wonder whether disruption mechanisms are only local or systemic and infarction is caused by an arbitrary plaque event or by a systemic, acute activity of the coronary disease. METHODS AND RESULTS Early (3 to 5 days) and late (1 month) peri-infarction coronary angiographic data in 23 patients with first infarction were compared with that in 23 similar patients, with angiography performed because of stable angina and repeated after 1 month before angioplasty. Nonculprit lesion changes at the narrowest point defined progression or regression when exceeding 0.27 mm. In patients with recent infarction we found that 16 had progression, 4 had regression, 1 had both, 2 were steady (values in patients with stable angina being 2 [P<.0011, 1 [NS], 0 [NS], and 20 [P<.001]); 27 lesions were infarct related; 17 of the 45 nonculprit lesions progressed and 5 regressed (values in stable angina being 2 [P<.001] and 1 [P<.05] out of 78); minimal diameter reduction of progressing stenoses averaged 0.39 mm; lumen increase of regressing lesions averaged 0.30 mm; 3 patients developed interim rest angina associated with progression of a nonculprit lesion. CONCLUSIONS A greater proportion of subjects and lesions with progression or regression (in infarction versus stable angina) supports the hypothesis that infarction is a hallmark of systemic coronary disease activity. Changes might vary according to the "maturation" stage of an atheroma, and maximal expression would be at the level of the offending plaque. Shrinkage, thrombolysis, or vascular remodeling would determine the residual plaque morphology.
Intestinal malabsorption of d-xylose: Comparison of test modalities in patients with celiac disease

Abstract Objective. The aim of the study was to compare three different D-xylose test modalities for small intestinal malabsorption, using patients with celiac disease and healthy persons as experimental models. Material and methods. Ninety-one untreated celiac patients, 98 treated celiac patients, and 43 healthy subjects performed the 13C-d-xylose breath test. 1-h plasma d-xylose levels were measured in 48 untreated patients, 41 treated patients and 41 healthy controls. 4-h urine d-xylose excretion was measured in 47 untreated patients, 51 treated patients and 42 healthy controls. 100 mg of 13C-d-xylose and 5 g of d-xylose were dissolved in 250 ml tap water and given orally. 13CO2 was measured in breath every 30 min for 4 h. Blood was sampled after 1 h, and urine collected after 4 h. Results. Test sensitivity/specificity for celiac disease was 88%/84% with the 13C-d-xylose breath test, 65%/71% with the 1-h plasma d-xylose test, and 55%/74% with the 4-h urine d-xylose excretion test. Breath test results improved significantly in the treated celiac group compared to untreated patients, but were not normalized compared to healthy controls. No difference was found between 1-h plasma d-xylose levels and 4-h urinary d-xylose excretion in treated celiac patients and healthy controls. Conclusions. The 13C-d-xylose breath test was superior to d-xylose testing in plasma and urine for assessment of small intestinal malabsorption with considerably higher sensitivity and specificity for untreated celiac disease.
Functional characteristics of rat gastrocnemius and tibialis anterior muscles during growth

Several morphological and functional characteristics of the rat gastrocnemius medialis and tibialis anterior muscle were studied in young, adult, and old rats to assess the influence of growth. Antagonist muscles were studied to determine how changes of muscle architecture and functional characteristics are influenced by the demands of increased body weight and by the specific roles of these muscles in locomotion.
Skin protective effect of guava leaves against UV‐induced melanogenesis via inhibition of ORAI1 channel and tyrosinase activity

Ultraviolet (UV) irradiation is a major environmental factor affecting photoageing, which is characterized by skin wrinkle formation and hyperpigmentation. Although many factors are involved in the photoageing process, UV irradiation is thought to play a major role in melanogenesis. Tyrosinase is the key enzyme in melanin synthesis; therefore, many whitening agents target tyrosinase through various mechanisms, such as direct interference of tyrosinase catalytic activity or inhibition of tyrosinase mRNA expression. Furthermore, the highly selective calcium channel ORAI1 has been shown to be associated with UV‐induced melanogenesis. Thus, ORAI1 antagonists may have applications in the prevention of melanogenesis. Here, we aimed to identify the antimelanogenesis agents from methanolic extract of guava leaves (Psidium guajava) that can inhibit tyrosinase and ORAI1 channel. The n‐butanol (47.47%±7.503% inhibition at 10 μg/mL) and hexane (57.88%±7.09% inhibition at 10 μg/mL) fractions were found to inhibit ORAI1 channel activity. In addition, both fractions showed effective tyrosinase inhibitory activity (68.3%±0.50% and 56.9%±1.53% inhibition, respectively). We also confirmed that the hexane fraction decreased the melanin content induced by UVB irradiation and the ET‐1‐induced melanogenesis in murine B16F10 melanoma cells. These results suggest that the leaves of P. guajava can be used to protect against direct and indirect UV‐induced melanogenesis.
Effects of Peritoneal Dialysis Solutions on the Secretion of Growth Factors and Extracellular Matrix Proteins by Human Peritoneal Mesothelial Cells

♦ Objective To compare the effects of different peritoneal dialysis solutions (PDS) on secretion of vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGFβ1), procollagen I C-terminal peptide (PICP), procollagen III N-terminal peptide (PIIINP), and fibronectin by cultured human peritoneal mesothelial cells (HPMC). ♦ Design Using M199 culture medium as control, commercial PDS containing 1.5% or 4.25% glucose and 40 mmol/L lactate [Dianeal 1.5 (D 1.5) and Dianeal 4.25 (D 4.25), respectively; Baxter Healthcare, Deerfield, Illinois, USA]; PDS containing 1.5% or 4.25% glucose with 25 mmol/L bicarbonate and 15 mmol/L lactate [Physioneal 1.5 (P 1.5) and Physioneal 4.25 (P 4.25), respectively; Baxter]; and PDS containing 7.5% icodextrin [Extraneal (E); Baxter] were tested. Growth-arrested and synchronized HPMC were continuously stimulated for 48 hours by test PDS diluted twofold with M199, TGFβ1 1 ng/mL, or different concentrations of icodextrin. VEGF, TGFβ1, and fibronectin secreted into the media were analyzed by ELISA, and PICP and PIIINP by radioimmunoassay. ♦ Results Dianeal 1.5, D 4.25, and P 4.25, but not P 1.5 and E, significantly increased VEGF secretion compared with control M199. D 4.25- and P 4.25-induced VEGF secretion was significantly higher than induction by D 1.5 and P 1.5, respectively, suggesting that high glucose may be involved in the induction of VEGF. Physioneal 1.5- and P 4.25-induced VEGF secretion was significantly lower than induction by D 1.5 and D 4.25, respectively, suggesting a role for glucose degradation products (GDP) in VEGF production. TGFβ1 secretion was significantly increased by D 4.25 and E. Icodextrin increased TGFβ1 secretion in a dose-dependent manner. All PDS tested significantly increased secretion of PIIINP compared with control. D 1.5- and D 4.25-induced PIIINP secretion was significantly higher than P 1.5, P 4.25, and E. Physioneal 4.25-induced PIIINP secretion was significantly higher than P 1.5, again implicating high glucose and GDP in PIIINP secretion by HPMC. There was no significant increase in PICP or fibronectin secretion using any of the PDS tested. Addition of TGFβ1 1 ng/mL into M199 control significantly increased VEGF, PICP, PIIINP, and fibronectin secretion by HPMC. ♦ Conclusions The present study provides direct evidence that HPMC can secrete VEGF, TGFβ1, and PIIINP in response to PDS, and that HPMC may be actively involved in the development and progression of the peritoneal membrane hyperpermeability and fibrosis observed in long-term PD patients. This study also suggests that both high glucose and GDP in PDS may play important roles in inducing VEGF and PIIINP production/secretion by HPMC.
RMM: A Recursive Mental Model for Dialog Navigation

Language-guided robots must be able to both ask humans questions and understand answers. Much existing work focuses only on the latter. In this paper, we go beyond instruction following and introduce a two-agent task where one agent navigates and asks questions that a second, guiding agent answers. Inspired by theory of mind, we propose the Recursive Mental Model (RMM). The navigating agent models the guiding agent to simulate answers given candidate generated questions. The guiding agent in turn models the navigating agent to simulate navigation steps it would take to generate answers. We use the progress agents make towards the goal as a reinforcement learning reward signal to directly inform not only navigation actions, but also both question and answer generation. We demonstrate that RMM enables better generalization to novel environments. Interlocutor modelling may be a way forward for human-agent RMM where robots need to both ask and answer questions.
Satisfaction and Quality of Life in Laryngectomees after Voice Prosthesis Rehabilitation

Objective/Hypothesis: The purpose of the study was to assess the satisfaction and quality of life in laryngectomees after vocal rehabilitation using voice prostheses. We evaluated the impact on quality of life between laryngectomees with voice prostheses, laryngectomees without them and healthy controls. Methods: This was a prospective study on a sample of laryngectomees in an Italian university hospital. Our study population was composed of 42 patients who had previously undergone a total laryngectomy; in 24 of them, voice rehabilitation was obtained with a voice prosthesis device (group A), while 18 of them learned oesophageal voice (group B). The results were compared with a group of 25 healthy controls (group C). In order to investigate the quality of life, we administered the Short Form 36-Item Health Survey (SF-36) to the 3 groups. Moreover, self-satisfaction of the subjects in group A was assessed by single questions regarding their use of the voice prosthesis. Results: A statistical difference in the SF-36 was detected for social functioning (SF) between groups A and B. Role physical, SF and role emotional were significantly better in group C than in group A. Group A stated they were very satisfied with voice quality while there were still some problems regarding prosthesis lifetime and communication at the telephone or in noisy environments. Conclusions: Voice prosthesis implantation in laryngectomees showed positive effects on patients’ quality of life; however, there are still some negative aspects. At present, an early diagnosis of larynx cancer with a partial laryngectomy in order to preserve phonatory function is the gold standard.
SHORT COMMUNICATION Chemical composition and antioxidant activity of a polar extract of Thymelaea microphylla Coss. et Dur

Thymelaea microphylla Coss. et Dur. (Thymelaeaceae) is a rare medicinal plant endemic to Algeria. In order to continue our studies on this species, herein we report the isolation and characterisation of 20 compounds from a hydroalcoholic extract (EtOH– H2O 7:3) of the aerial parts. They include monoterpene glucosides (1–3), phenolic acid derivatives (4, 8 and 9), phenylpropanoid glucosides (5 and 6), flavonoids (7, 10 and 11), a benzyl alcohol glucoside (12), ionol glucosides (13–16), lignans (17–19) and a bis-coumarin (20). All the structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments, as well as ESI-MS analysis. Moreover, the extract of T. microphylla showed a significant and concentration-dependent free radical-scavenging activity in vitro, correlated to the presence of phenolic and chlorogenic acid derivatives (8, 9 and 4).
Relation of carotid intima-media thickness and silent cerebral infarction to cardiovascular events and all-cause mortality in chronic hemodialysis patients.

OBJECTIVE Silent cerebral infarction (SCI) and increased carotid intima-media thickness (IMT) have been found to be associated with future stroke in the general population. We investigated whether a combination of SCI and increased IMT is a predictor of cardiovascular events and all-cause mortality in chronic hemodialysis (HD) patients. METHODS We performed a retrospective cohort study of 70 HD patients who had one or more risk factors for atherosclerosis but no history of cardiovascular disease. We performed cranial magnetic resonance imaging (MRI) and measured carotid IMT at baseline, and then evaluated the risks of cardiovascular events and all-cause mortality by using Cox proportional hazards models. The Kaplan-Meier method and a log-rank test were used to compare event-free survival. RESULTS SCI was present in 25 patients (35.7%) at baseline. During an average follow-up of 46.3 ± 14.3 months (range: 19 to 56 months), 15 patients (21.4%) died and 16 (22.9%) experienced a new cardiovascular event. The presence of SCI in combination with increased carotid IMT at baseline was independently associated with cardiovascular events and all-cause mortality after adjustment for age, sex, duration of dialysis, and traditional vascular risk factors. CONCLUSION SCI, similar to carotid IMT, is an independent predictor of cardiovascular events and all-cause mortality in chronic HD patients.
Classification based character segmentation guided by Fast-Hessian-Affine regions

This paper presents a method of fast and accurate character localization for OCR (Optical Character Reader). We already proposed an acceleration framework of arbitrary classifiers, classifier molding, for real-time verification of characters printed by Industrial Ink Jet Printer (IIJP). In this framework, the behavior of accurate but slow character classifier is learnt by linear regression tree. The resulted classifier is up to 1,500 times faster than the original one but is not fast enough for real-time pyramidal scan of VGA images, which is necessary for scale-free character recognition. For solving this problem, we also proposed CCS (Classification based Character Segmentation). This method finds character arrangement that maximizes the sum of the likelihood of character regions assuming that all characters are horizontally aligned with almost regular intervals. This assumption is not always true even for the characters printed by IIJP. For solving this problem, we extended the idea of CCS to arbitrary located characters. Our method first generates character-region candidates based on local elliptical regions, named Fast-Hessian-Affine regions, and finds most likely character arrangement. Through experiments, we confirmed that our method quickly and accurately recognizes non-uniformly arranged characters.
Max-K-Min Distance Analysis for Dimension Reduction

We propose a new criterion for discriminative dimension reduction, Max-K-Min Distance Analysis (MKMDA). Given a data set with C classes, MKMDA maximizes the sum of the K minimum pair wise distance of these C classes on the selected one-dimensional subspace. The set of the possible one-dimensional subspace, for which the order of the projected class centroids is identical, define a convex region with associated convex sum of K smallest margin functions. This allows for the maximization of the margin function using standard convex optimization algorithms. This result is further extended to obtain the d-dimensional subspace for any given d by iterative applying our algorithm to the null space of the (d -- 1)-dimensional subspace. The effectiveness of the proposed criterion and corresponding algorithm is shown by the visualization and classification experiments on both synthetic data and real data sets.