Miracle-dz/UniFAR-FTUs huggingface dataset:
Automated Game Testing with ICARUS: Intelligent Completion of Adventure Riddles via Unsupervised Solving

With ICARUS, we introduce a framework for autonomous video game playing, testing, and bug reporting. We report on the design rationale, the practical implementation, and its use in game development industry projects. The underlying solving mechanic is based on discrete reinforcement learning in a dualistic fashion, encompassing volatile short-term memory as well as persistent long-term memory that spans across distinct game iterations. In combination with heuristics that reduce the search space and the possibility to employ pre-defined situation-dependent action choices, the system manages to traverse complete playthrough iterations in roughly the same amount of time that a professional game tester requires for a speedrun. The ICARUS project was developed at Daedalic Entertainment. The software can be used to generically run all adventure games built with the popular Visionaire Engine and is currently used for evaluating daily builds, for large-scale hardware compatibility and performance tests, as well as for semi-supervised quality assurance playthroughs. The supplementary video depicts real-time solving with active control and observation via a web control panel.
Prevalence and severity of disordered mineral metabolism in patients with chronic kidney disease: A study from a tertiary care hospital in India

Background: Disordered mineral metabolism is common complications of chronic kidney disease (CKD). However, there are limited data on the pattern of these disturbances in Indian CKD population. Materials and Methods: This was a prospective observational study of CKD-mineral and bone disorder (CKD-MBD) over a period of 3 years. The biochemical markers of CKD-MBD, namely, calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone (iPTH), and 25-hydoxyvitamin Vitamin D3 (25OHD), were measured in newly diagnosed CKD Stage 3–5 and prevalent CKD Stage 5D adult patients. Results: A total of 462 patients of CKD Stage 3–5D were studied. The frequency of various biochemical abnormalities was hypocalcemia (23.8%), hypercalcemia (5.4%), hypophosphatemia (2.8%), hyperphosphatemia (55.4%), raised alkaline phosphatase (56.9%), secondary hyperparathyroidism (82.7%), and hypoparathyroidism (1.5%). 25OHD was done in 335 (72.5%) patients and 90.4% were found to have Vitamin D deficiency. About 70.6% of the patients had iPTH levels were above kidney disease outcomes quality initiative (KDOQI) target range. Nondiabetic CKD as compared to diabetic CKD had a higher alkaline phosphatase (P = 0.016), a higher iPTH (P = 0.001) a higher proportion of patients with iPTH above KDOQI target range (P = 0.09), and an elevated alkaline phosphatase (P = 0.004). The 25OHD levels were suggestive of severe Vitamin D deficiency in 33.7%, Vitamin D deficiency in 45.4%, and Vitamin D insufficiency in 11.3% patients. There was a significant positive correlation between iPTH with alkaline phosphatase (r = 0.572, P = 0.001), creatinine (r = 0.424, P = 0.001), and phosphorus (r = 0.241, P = 0.001) and a significant negative correlation with hemoglobin (r = −0.325, 0.001), age (r = −0.169, P = 0.002), and 25OHD (r = −0.126, P = 0.021). On multivariate logistic regression analysis, an elevated alkaline phosphatase was a significant predictor of hyperparathyroidism (odds ratio 9.7, 95% confidence interval 4.9–19.2, P = 0.001). Conclusions: There was a high prevalence of CKD-MBD in Indian CKD patients. CKD-MBD is more common and more severe and has an early onset as compared to the western populations.
Within‐farm spread of classical swine fever virus – a blueprint for a stochastic simulation model

Summary A stochastic simulation model to investigate the transmission of classical swine fever (CSF) virus within an infected farm is described. The model is structured according to the processes that occur within and between management groups (pig units or houses). It uses the individual pig as the unit of interest and estimates the number of animals in the states ‘susceptible’, ‘infected’, ‘infectious’, and ‘removed’ for each day of the disease incident. Probabilities are assigned to the transitions between states. The probability of a pig becoming infected is made dependent on the probability of contact between a susceptible and an infectious pig as well as the probability of transmission. The more pigs become infected in one unit, the more likely is subsequent spread to another management group on the farm. Ultimately, the probability that a shipment of pigs from the farm will include at least one infected pig can be estimated in order to identify high‐risk movements during a CSF epidemic. The model results were compared with experimental data on CSF transmission within one pig unit (management group). It could be shown that the model was capable of reproducing the experimentally observed infection and mortality rates. To improve the input parameters and for further model validation, more experimental data and field data from CSF outbreaks are needed.
Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation.

The effect of platelet-activating factor (acetyl glyceryl ether phosphorylcholine; PAF), a potent inflammatory mediator, on airway responsiveness was studied. In six dogs airway responsiveness was determined by measuring the provocative concentration of acetylcholine aerosol that increased total pulmonary resistance (RL) by 5 cm H2O X L-1 X s, before and after inhalation of PAF (1 mg). PAF caused a 2.3-fold increase in RL (P less than .001) that lasted approximately 30 min. Airway hyperresponsiveness was maximal at 3 hr (mean 3.7-fold increase, P less than .001), persisted at 6 hr (P less than .005) and disappeared by 24 hr. Inhalation of 0.9% NaCl had no effect on RL or on responsiveness. PAF caused an 8-fold increase in neutrophil recovery in bronchoalveolar lavage fluid at 3 hr. OKY-046, a thromboxane synthetase inhibitor, inhibited PAF-induced bronchoconstriction and hyperresponsiveness but did not alter the increase in neutrophil recovery. We tested the specificity of the effect of OKY-046 on the release of cyclooxygenase products from canine neutrophils in vitro; OKY-046 suppressed PAF-induced generation of thromboxane and caused a small increase in prostaglandin F2 alpha release. The studies suggest that the airway hyperresponsiveness induced by PAF may depend on thromboxane generation.
Hepatic resection for hepatolithiasis.

OBJECTIVE To analyze the results of hepatic resection for hepatolithiasis. DESIGN A retrospective study of case records of patients with hepatolithiasis undergoing hepatic resection. These patients had been followed up for 3 to 38 months. They were referred to Queen Mary Hospital, a tertiary referral center in Hong Kong. PATIENTS Of 172 patients with hepatolithiasis seen between January 1984 and December 1981, 63 patients underwent hepatic resection because the affected liver segments were destroyed by repeated infection (n = 51), multiple cholangitic liver abscesses were found in the affected liver segments (n = 9), or concomitant intrahepatic cholangiocarcinoma was diagnosed (n = 3). INTERVENTION Left lateral segmentectomy was performed in 42 patients, left hepatic lobectomy in 15 patients, right hepatic lobectomy in one patient, and segmentectomy in five patients. MAIN OUTCOME MEASURES Postoperative morbidity and mortality analysis. RESULTS Contrary to hepatic resection in a normal liver, dissection to isolate inflow and outflow vasculature was difficult in 52% of cases owing to severe inflammatory fibrosis at the liver hilum, at the umbilical fissure, or at the junction of hepatic vein with inferior vena cava. The operative morbidity rate was 32% and the mortality rate was 2%. The majority of complications were wound infection, subphrenic abscesses, or biliary fistulas, which could be due to the presence of infected bile (85%) and liver abscesses (25%) in this disease. Statistical analysis of the preoperative hematological and biochemical variables and the amount of intraoperative blood loss could not identify any factor with significance in correlating with the development of postoperative complications. Stones recurred in 16% after a median follow-up of 47 months. CONCLUSION Hepatic resection is a satisfactory treatment for hepatolithiasis. The postoperative septic complication rate is high and is an intrinsic problem related to liver resection in a septic condition.
Model predictive control of packed U cells based transformerless single-phase dynamic voltage restorer

Power quality has become a matter of great concern for all energy stakeholders, whether they are network operators, suppliers, producers, or end users. One of the main power quality issues affecting sensitive equipment and loads are short-time voltage variations (disturbances) called voltage sags and swells. This paper focuses on the mitigation of these voltage disturbances using a novel packed U cells (PUC) based dynamic voltage restorer (DVR) solution. The proposed DVR is controlled by using a multi-constraint model predictive control (MPC) approach, which regulates the injection of the needed compensation voltage in series and synchronism with the grid during the voltage disturbance events. Moreover, as it is mandatory to ensure stable operation of the PUC inverter, the proposed MPC ensures the control of the PUC output current while maintaining the capacitor voltage at its nominal value. Theoretical analysis and simulation results are given to show the high performance of the proposed solution.
Further reliability analysis of the Harrison radiographic line-drawing methods: crossed ICCs for lateral posterior tangents and modified Risser-Ferguson method on AP views.

OBJECTIVE To determine whether the newly derived interclass and intraclass correlation coefficients (ICCs)would overstate or understate the results from 2 previously published studies, which used better known ICCs that assume nested factors, and to determine mean absolute differences of observers' measurements for 3 previous studies. STUDY DESIGN Retrospective analysis of data from 2 blind studies with repeated-measure design. Two newly derived ICCs, appropriate to situations with 3 random factors (patients, examiners, and occasions) that bear a crossed (as opposed to nested) interrelationship, were applied to data from an experiment with random crossed factors. MAIN OUTCOME MEASURES Observer reliability is determined with ICCs, 95% CIs, and observer error analysis (mean absolute differences of observers' measurements) for angles and distances derived from Harrison's modified Risser-Ferguson line-drawing method on anteroposterior (AP) lumbar and AP cervical radiographic views. Observer error analysis for angles and distances derived from Harrison's posterior tangent method on lateral cervical views was also determined. RESULTS The majority of ICCs for reliability of line drawing on both AP cervical and AP lumbar radiographs were in the high range; 13 of 16 ICCs were greater than 0.88. The other 3 ICC values (0.61, 0.76, 0.78) concerned determining the sacral base on AP lumbar views. The new ICCs underestimated observer reliability compared with previously published results (intraclass ICCs lower by 0.01-0.02 and interclass ICCs lower by 0.03-0.10). For an error analysis on data from both AP views, the mean absolute differences of observers' measurements were 1.1 degrees to 1.8 degrees for angles and 1.2 mm to 2.3 mm for distances. For the lateral cervical analysis, the observer error was in the interval 0.8 degrees to 3.2 degrees for angles and <1 mm for distances. CONCLUSIONS The ICCs assuming random crossed factors understate reliability compared with previously published ICC results assuming nested factors. Reliability of the Harrison modified Risser-Ferguson method of line-drawing analysis on AP views is in the high range, with the majority of ICCs >0.88. For both the Harrison modified Risser-Ferguson method on AP views and posterior tangent method on lateral cervical views, the mean absolute differences of observers' measurements are small.
Results from a rosuvastatin historical cohort study in more than 45 000 Dutch statin users, a PHARMO study

Clinical benefits of statin therapy are accepted, but their safety profiles have been under scrutiny, particularly for the recently introduced statin, rosuvastatin, relating to serious adverse events involving muscle, kidney and liver. Therefore, a historical cohort study was performed to evaluate the association between rosuvastatin versus other statin use and the incidence of rhabdomyolysis, myopathy, acute renal failure and hepatic impairment.
A shape theorem for the scaling limit of the IPDSAW at criticality

In this paper we give a complete characterization of the scaling limit of the critical Interacting Partially Directed Self-Avoiding Walk (IPDSAW) introduced in Zwanzig and Lauritzen (1968). As the system size $L$ diverges, we prove that the set of occupied sites, rescaled horizontally by $L^{2/3}$ and vertically by $L^{1/3}$ converges in law for the Hausdorff distance towards a non trivial random set. This limiting set is built with a Brownian motion $B$ conditioned to come back at the origin at $a_1$ the time at which its geometric area reaches $1$. The modulus of $B$ up to $a_1$ gives the height of the limiting set, while its center of mass process is an independent Brownian motion. Obtaining the shape theorem requires to derive a functional central limit theorem for the excursion of a random walk with Laplace symmetric increments conditioned on sweeping a prescribed geometric area. This result is proven in a companion paper arXiv:1709.06448.
Endoscopist factors that influence serrated polyp detection: a multicenter study

Abstract Background Serrated polyps are important colorectal cancer precursors that are variably detected during colonoscopy. We measured serrated polyp detection rate (SPDR) in a large, multicenter, cross-sectional study of colonoscopy quality to identify drivers of SPDR variation. Methods Colonoscopy and pathology reports were collected for a 2-year period (10/2013-9/2015) from four sites across the United States. Data from reports, including size, location, and histology of polyps, were abstracted using a validated natural language processing algorithm. SPDR was defined as the proportion of colonoscopies with ≥ 1 serrated polyp (not including hyperplastic polyps). Multivariable logistic regression was performed to determine endoscopist characteristics associated with serrated polyp detection. Results A total of 104 618 colonoscopies were performed by 201 endoscopists who varied with respect to specialty (86 % were gastroenterologists), sex (18 % female), years in practice (range 1 – 51), and number of colonoscopies performed during the study period (range 30 – 2654). The overall mean SPDR was 5.1 % (SD 3.8 %, range 0 – 18.8 %). In multivariable analysis, gastroenterology specialty training (odds ratio [OR] 1.89, 95 % confidence interval [CI] 1.33 – 2.70), fewer years in practice (≤ 9 years vs. ≥ 27 years: OR 1.52, 95 %CI 1.14 – 2.04)], and higher procedure volumes (highest vs. lowest quartile: OR 1.77, 95 %CI 1.27 – 2.46)] were independently associated with serrated polyp detection. Conclusions Gastroenterology specialization, more recent completion of training, and greater procedure volume are associated with serrated polyp detection. These findings imply that both repetition and training are likely to be important contributors to adequate detection of these important cancer precursors. Additional efforts to improve SPDR are needed.
Plasma antioxidant status and cell injury after severe physical exercise

Strenuous exercise leads to an increase in metabolic rate, increased production of reactive oxygen species, and compromised antioxidant defense systems. To study the effects of oxidative stress during strenuous exercise, a homogeneous group of 31 male subjects participated in a 6-month, 5 days/week training schedule involving two extreme marches of 50 km and 80 km at sea level, separated by 2 weeks of regular training. Each participant carried 35 kg of extra weight. Blood samples were drawn imediately before and after each march. Twenty-nine subjects completed the 50-km march, and only 16 completed the 80-km march. Plasma levels of reduced ascorbic acid, total ascorbate, and dehydroascorbate did not undergo significant changes during either march. However, the 50- and 80-km marches led to 25% and 37% increases, respectively, in plasma levels of uric acid; due presumably to increases in the metabolic rate and consequent pyrimidine nucleotide metabolism. Both marches led to ≈10-fold increase leakage of creatine phosphokinase into the plasma. Likewise, plasma levels of aspartate transaminase, a characteristic marker of liver injury, increased ≈4-fold. Plasma levels of bilirubin, creatine, urea, and glucose also increased. Plasma protein carbonyl content, a marker of protein oxidative damage, decreased significantly during each march. These results are discussed with respect to the consideration that elevation of the respiration rate during exercise leads to production of more reactive oxygen species than the antioxidant systems can scavenge. Plausible explanations for leakage of molecules into the plasma are discussed.
A geography‐aware reconciliation method to investigate diversification patterns in host/parasite interactions

Cospeciation studies aim at investigating whether hosts and symbionts speciate simultaneously or whether the associations diversify through host shifts. This problem is often tackled through reconciliation analyses that map the symbiont phylogeny onto the host phylogeny by mixing different types of diversification events. These reconciliations can be difficult to interpret and are not always biologically realistic. Researchers have underlined that the biogeographic histories of both hosts and symbionts influence the probability of cospeciation and host switches, but up to now no reconciliation software integrates geographic data. We present a new functionality in the Mowgli software that bridges this gap. The user can provide geographic information on both the host and symbiont extant and ancestral taxa. Constraints in the reconciliation algorithm have been implemented to generate biologically realistic codiversification scenarios. We apply our method to the fig/fig wasp association and infer diversification scenarios that differ from reconciliations ignoring geographic information. In addition, we updated the reconciliation viewer SylvX to visualize ancestral character states on the phylogenetic trees and highlight parts of reconciliations that are geographically inconsistent when not accounting for geographic constraints. We suggest that the comparison of reconciliations obtained with and without such constraints can help solving ambiguities in the biogeographic histories of the partners. With the development of robust methods in historical biogeography, and the advent of next‐generation sequencing that leads to better‐resolved trees, a geography‐aware reconciliation method represents a substantial advance that is likely to be useful to researchers studying the evolution of biotic interactions and biogeography.
Studying meiotic cohesin in somatic cells reveals that Rec8-containing cohesin requires Stag3 to function and is regulated by Wapl and sororin

ABSTRACT The DNA-embracing, ring-shaped multiprotein complex cohesin mediates sister chromatid cohesion and is stepwise displaced in mitosis by Wapl and separase (also known as ESPL1) to facilitate anaphase. Proper regulation of chromosome cohesion throughout meiosis is critical for preventing formation of aneuploid gametes, which are associated with trisomies and infertility in humans. Studying cohesion in meiocytes is complicated by their difficult experimental amenability and the absence of cohesin turnover. Here, we use cultured somatic cells to unravel fundamental aspects of meiotic cohesin. When expressed in Hek293 cells, the kleisin Rec8 displays no affinity for the peripheral cohesin subunits Stag1 or Stag2 and remains cytoplasmic. However, co-expression of Stag3 is sufficient for Rec8 to enter the nucleus, load onto chromatin, and functionally replace its mitotic counterpart Scc1 (also known as RAD21) during sister chromatid cohesion and dissolution. Rec8–Stag3 cohesin physically interacts with Pds5, Wapl and sororin (also known as CDCA5). Importantly, Rec8–Stag3 cohesin is shown to be susceptible to Wapl-dependent ring opening and sororin-mediated protection. These findings exemplify that our model system is suitable to rapidly generate testable predictions for important unresolved issues of meiotic cohesion regulation. Summary: Rec8-mediated cohesion is reconstituted in a somatic cell line and shown to chiefly depend on co-expression of Stag3. Rec8–Stag3-containing cohesin is antagonised by Wapl and protected by sororin.
Third Harmonic Current Injection in Fault-Tolerant Five-Phase Permanent-Magnet Motor Drive

This paper presents a third harmonic current injection method for a five-phase permanent-magnet (PM) motor with trapezoidal back electromotive force (EMF) under postfault field oriented control (FOC). The key of the proposed method is the third harmonic current online calculation and injection under postfault FOC. The postfault FOC lies in the fundamental decoupled model based on the concept of maintaining spatial circular rotation of fundamental PM flux linkage vector and magnetic motive force under open-circuit fault. Based on the mathematical model of torque pulsations caused by third harmonics of air-gap flux, the injected third harmonic current can be calculated by the radio of the amplitude of third harmonic EMF and fundamental EMF easily. The presented fault-tolerant control strategy can achieve the real time optimal current reference generation and third harmonic current injection under postfault FOC while reducing the torque pulsations. The effectiveness of the proposed method is verified by experimental results under various operation conditions.
Limit theory for geometric statistics of clustering point processes

Let $\mathcal{P}$ be a simple, stationary, clustering point process on $\mathbb{R}^d$ in the sense that its correlation functions factorize up to an additive error decaying exponentially fast with the separation distance. Let $\mathcal{P}_n:= \mathcal{P} \cap W_n$ be its restriction to windows $W_n := [- \frac{n^{1/d}}{2}, \frac{n^{1/d}}{2}]^d \subset \mathbb{R}^d$. We consider the statistic $H_n^\xi:= \sum_{x \in \mathcal{P}_n} \xi(x, \mathcal{P}_n)$ where $\xi(x, \mathcal{P}_n)$ denotes a score function representing the interaction of $x$ with respect to $\mathcal{P}_n$. When $\xi$ depends on local data in the sense that its radius of stabilization has an exponential tail, we establish expectation asymptotics, variance asymptotics, and central limit theorems for $H_n^\xi$ and, more generally, for statistics of the random measures $\mu_n^{\xi} := \sum_{x \in \mathcal{P}_n} \xi(x, \mathcal{P}_n) \delta_{n^{-1/d} x},$ as $W_n \uparrow \mathbb{R}^d$. This gives the limit theory for non-linear geometric statistics (such as clique counts, the number of Morse critical points, intrinsic volumes of the Boolean model, and total edge length of the $k$-nearest neighbor graph) of determinantal point processes with fast decreasing kernels, including the $\alpha$-Ginibre ensembles, extending the Gaussian fluctuation results of Soshnikov [67] to non-linear statistics. It also gives the limit theory for geometric U-statistics of permanental point processes as well as the zero set of Gaussian entire functions, extending the central limit theorems of Nazarov and Sodin [50], which are also confined to linear statistics. The proof of the central limit theorem relies on a factorial moment expansion originating in [10,11] to show clustering of mixed moments of $\xi$. Clustering extends the cumulant method to the setting of purely atomic random measures, yielding the asymptotic normality of $\mu_n^{\xi}$.