Miracle-dz/UniFAR-FTUs huggingface dataset:
Carga, ansiedad y depresión en cuidadores primarios informales de niños con cáncer Burden, anxiety and depression in informal primary caregivers of children with cancer

The research literature related to anxiety, depression and burden has shown that these components are relevant to understanding the implications of caring for patients with chronic diseases. Few studies establish a clear relationship among these variables for caregivers of children with chronic diseases. The objective of the present study was to determine the relationship between burden, anxiety, depression and care characteristics in a group of non-professional primary caregivers of children with cancer, in a Mexico City public hospital. The nonrandom sample consisted of 93 women and 7 men, who responded to a battery of tests composed of the Zarit %
Role of caspase-12 in cerebral neuron apoptosis mediated by ER stress after fetal rat ischemia/reperfusion injury

Objective To investigate the relationship between caspase-12 activation and neuron apoptosis mediated by endoplasmic reticulum(ER) stress after fetal rats ischemia/reperfusion injury.Methods To establish the model of ischemia/reperfusion injury and to take away the fetal brain for TUNEL analysis.The expression of caspase-12 in hippocampus CA1 area was analyzed by immunohistochemistry technique.Results The apoptotic neurons in hippocampus CA1 area were(43.6±11.4),(64.4±9.3),(74.2±12.1),(97.3±8.9)/mm2,after ischemia 15min reperfusion for 3,6,12,24h,respectively.From the time of reperfusion for 3h,apoptotic neurons increased significantly(P0.001),compared with the control group(20.2±9.9)/mm2,and the peak was at 24h.The expression of caspase-12 were 0.41±0.12,0.51±0.21,0.59±0.16,0.31±0.09 respectively,the differences were significant compared with the control(0.01±0.01),(P0.001). And the peak appeared at 12h.Conclusion Procaspase-12 activation might play an important role in neuron apoptosis mediated by ER stress.
A Climate Classification of China through k-Nearest-Neighbor and Sparse Subspace Representation

Climate classification aims to divide a given region into distinct groups on the basis of meteorological variables, and it has important applications in fields such as agriculture and buildings. In this paper, we propose a novel spectral clustering–based method to partition 661 meteorological stations in China into several zones. First, the correlations are analyzed among five meteorological variables: daily average temperature, average relative humidity, sunshine hours, diurnal temperature range, and atmospheric pressure. The resulting weak linear correlation supports the classification under multiple views. Next, a similarity matrix/graph is constructed by combining the advantages of k-nearest-neighbor and sparse subspace representation. The blocking effect of the similarity matrix confirms the rationality of the classification. Then, we consider respectively the climate classification under a single view and multiple views. For the single view, atmospheric pressure has the highest imbalance degree, and sunshine hours and diurnal temperature range have the strongest classification consistency. The consistency rates are improved evidently in a multiple-view situation. Afterward, we propose a determining method for the number of clusters and make a sensitivity analysis on various parameters. Finally, we provide a further statistical analysis on the classification results and compare the consistency with another climate dataset. All experimental results show that the proposed classification method is feasible and effective in the climate zoning of China.
Evaluating effects of dredging-induced underwater sound on aquatic species : a literature review

At any given moment, there may be multiple underwater sounds emanating from both natural and anthropogenic sources. Dredging activities such as the excavation, transit, and placement of material generate underwater sound. This report documents research into the biological effects of underwater sound from dredging and other anthropogenic sources to help evaluate the potential ecological risks of dredging activities. Effects data generated from exposures to anthropogenic sound sources indicate that dredging-induced sounds do not pose a significant risk of direct injury or mortality to aquatic biota. A notable exception, and much less common, is blasting activities used to remove rock and other hard substrata in navigation channels. In terms of potential non-lethal responses, low-frequency sounds produced by dredging overlap with the hearing frequency ranges of select fish and mammal species, which may pose risks for auditory temporary threshold shifts, auditory masking, and behavioral responses. To better understand the ecological risk associated with dredging sounds, a risk-based approach is needed that utilizes the available data and other site-specific information appropriate for evaluating underwater sound. The information reported herein can be used in an exposure assessment as part of a broader framework for evaluating and managing underwater sound effects on aquatic life. DISCLAIMER: The contents of this report are not to be used for advertising, publication, or promotional purposes. Citation of trade names does not constitute an official endorsement or approval of the use of such commercial products. All product names and trademarks cited are the property of their respective owners. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. DESTROY THIS REPORT WHEN NO LONGER NEEDED. DO NOT RETURN IT TO THE ORIGINATOR. ERDC/EL TR-19-18 iii
The Clinicopathologic Study of Foreign Body Granuloma Induced by Injection of Filler

Background: With the popularization of soft tissue augmentation with dermal fillers, filler-related complications such as foreign body granuloma (FBG) are increasing. However, there has been no comprehensive study performed on FBG induced by dermal fillers in Korea to date. Objective: The purpose of this study was to investigate the clinicopathologic findings of FBG induced by injection of filler. Methods: Eighteen biopsy-proven cases of FBG due to injection of filler were reviewed and analyzed by their clinicopathological findings. In addition, the severity of granulomatous inflammation was graded by the classification proposed by Duranti. Results: Two patients were injected with silicone, one with collagen and fifteen with unknown materials; they were treated by unlicensed practioners. The interval time between the injection and the presence of FBG ranged from 2 months to 30 years (mean: 2 years). Most of the lesions presented as skin-colored or erythematous subcutaneous nodules. In one patient, concomitant infection was discovered and the cultured organisms were coagulase negative staphylococcus and Mycobacteria chelonae. The histopathologic findings showed variable infiltrations of inflammatory cells, predominantly lymphohistiocytes and in fifteen patients (83.3%) multinuclear giant cells were also seen. In ten patients (55.6%), marked foreign body granulomatous inflammation of Duranti grade II were observed. In ten cases (55.6%), ‘Swiss cheese appearance' representing granuloma due to lipoid materials such as silicone and paraffin were observed. Conclusion: This study shows various clinical presentations and histopathologic findings of FBGs incurred by filler injections, although most of the injected materials were not identified. Further investigations on different injectable products are necessary to identify the nature of the injected filler. (Korean J Dermatol 2007;45(3):255~261)
Analysis and Evaluation of the Urban Rainwater Harvesting System in Green Buildings

In the present study, urbanization provides residents with superior material and cultural living conditions, but also brings series of problems such as environmental pollution and water supply and drainage issues. Urban rainwater utilization is one of the method to solve urban water shortage and reduce waterlogging disaster.Taking an office building in Wuhan as an example, based on the analysis of rainfall characteristics in Wuhan, this thesis demonstrates a rainwater utilization system by rational use of the structural form of buildings, and analyzes and evaluates the function of the system with actual data. It is feasible and necessary to prove its comprehensive benefit according to the input and revenue. And the system is economic and reasonable for the project and the society as a whole. Based on the specific project, the author summarizes experiences and put forward effective suggestions.
Persistence of negative priming: Steady state or decay?

Responses to recently ignored stimuli may be slower and less accurate than responses to new stimuli. Neill and Westberry (1987) found that such negative priming effects dissipated within a 2-s interval between response and the next stimulus, the response-stimulus interval (RSI). However, experiments by Tipper, Weaver, Cameron, Brehaut, and Bastedo (1991) found negative priming persisted unchanged over RSIs from 1,350 to 6,600 ms. Our experiments used a letter-matching procedure in which target letters were flanked by irrelevant letters. Negative priming was manifested by longer reaction times and more errors to letters that had appeared as flankers in the preceding trial. RSI was varied from 500 to 8,000 ms.
Clinical outcomes of patients with major bleeding after primary coronary intervention for acute ST-segment elevation myocardial infarction

Objective To evaluate the clinical outcomes of patients complicated with major bleeding after primary coronary intervention(PCI) for acute ST-segment elevation myocardial infarction(STEMI). Methods During the period of January 2004-January 2008,primary PCI was performed in 412 consecutive patients with acute STEMI at Shanghai Ruijin Hospital.The clinical data were retrospectively analyzed.Major adverse cardiac events(MACE),including death,reoccurrence of myocardial infarction and target vessel revascularization,in patients with major bleeding were compared with that in patients without major bleeding.Results Compared to patients without bleeding,the patients with bleeding were older(70.0 ± 8.9 years vs 64.9 ± 12.7 years,P = 0.04),mainly the females(51.9% vs 23.1%,P = 0.001) and treated more often with glycoprotein(GP) Ⅱb / Ⅲa receptor inhibitor(88.9% vs 69.4%,P = 0.03) or intra-aortic balloon pump(7.4% vs 1.3%,P = 0.02). In-hospital and one-year MACE rate in the patients with bleeding was 18.5% and 37.0% respectively,which were significantly higher than that in the patients without bleeding(5.7% and 14.3%,with P = 0.008 and P = 0.002,respectively). Multivariate analysis indicated that patient aged over 70 years,feminine gender and use of GP Ⅱb / Ⅲa receptor inhibitor were independent predictors for the occurrence of major bleeding.The occurrence of major bleeding after primary PCI was significantly correlated with MACE occurred within one year after the procedure(OR 2.79,95% CI: 2.21-5.90,P 0.001). Conclusion In patients with acute STEMI,the occurrence of major bleeding after primary PCI is closely linked to the increased MACE rate within one year after the treatment.Feminine gender,aged patient and use of GPⅡb / Ⅲa receptor inhibitor are independent predictors to increase the danger of major bleeding.
Neurodevelopmental problems of late preterm fetuses and the factors affecting neurological morbidity

Objective: We aimed to investigate neurodevelopmental prognosis of late premature infants (between 32 and 37 weeks) and to determine antenatal, natal and postnatal risk factors affecting prognosis. Methods: The study was carried out on a total of 200 children (100 premature and 100 mature born) with no known chronic disease from 6-month-old up to 6-year-old born between January 2008 and January 2013 in the obstetrics clinic of Health Ministry Dr. Sami Ulus Training and Research Hospital and being followed up routinely in the Pediatric Psychiatry Clinic. The information of the children was obtained by a questionnaire form completed by their first degree relatives. Antenatal and natal risk factors were listed by analyzing the files. Psychosocial and motor developments of the children were assessed with Ankara Development Screening Inventory (AGTE), and premature and mature babies were compared in terms of neurological development. Results: While there was no statistically significant difference between the groups in our study in terms of chronological age and 1minute and 5-minute Apgar scores (p>0.05), the difference between delivery week and birth weight was statistically significant (p<0.05). It was found that late premature babies had significantly high level of RDS, hypothermia, hypoglycemia, jaundice, apnea and hospitalization period compared to mature babies (p<0.05). There was no significant relation between AGTE and the week of gestation, birth weight, antenatal steroid prophylaxis, 1-minute and 5-minute Apgar score, maternal educational level, and socio-economical level (p>0.05). Among the groups, there was statistically no significant difference in terms of general development, language development, fine and gross motor development and personal-social development (p>0.05). Conclusion: Although there was no significant difference between late premature and mature groups in terms of neurological development, late premature babies are under risk in terms of neonatal morbidity and mortality, and they encounter many problems. Therefore, delivery schedule should be planned carefully by considering prematurity risks against the maternal and fetal complication risks if it is decided to maintain pregnancy. In addition, either the periods of follow-up besides mothers for late premature babies should be extended or these babies should be followed-up more closely in the first days after discharge.
ANALISIS PERAN SEKTOR PARIWISATA DALAM PEMBANGUNAN DAERAH DI KABUPATEN LOMBOK BARAT (Pendekatan Location Quotient dan Klassen Typology Analysis)

Abstrak Penelitian ini bertujuan untuk menganalisis seberapa besar potensi sektor pariwisata menjadi sektor unggulan dan bagaimana daya saing sektor pariwisata terhadap sektor-sektor unggulan lainnya di kabupaten Lombok Barat. Data yang digunakan adalah data sekunder yang diambil dari Badan Pusat Statistik kabupaten Lombok Barat dan Provinsi Nusa Tenggara Barat. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan menggunakan alat analisis Location Quotient (LQ) dan Tipologi Klassen. Hasil penelitian menunjukkan bahwa sektor pariwisata (penyediaan akomodasi dan makan minum) mempunyai nilai LQ>1 yang artinya bahwa sektor pariwisata relatif terspesialisasi secara berlebihan pada aktivitas ekonomi di kabupaten lombok Barat sedangkan hasil dari analisis tipologi klassen hasilnya menunjukkan sektor pariwisata di kabupaten Lombok Barat mempunyai tingkat daya saing yang tinggi dengan hasil analisis bahwa sektor pariwisata berada di kuadran I yang artinya sektor pariwisata adalah sektor maju dan tumbuh cepat. Kata kunci: Sektor pariwisata, PDRB, LQ, Tipologi Klassen
The transfer and ecological effects of xenobiotic pollution on freshwater ecosystems

1. The diversity of synthetic, xenobiotic chemicals reaching the wider environment has increased rapidly over the past century. The nature and severity of their ecological effects in freshwater systems, however, remains poorly understood, even for the so-called ‘legacy’ pollutants. These persistent, bioaccumulative and toxic compounds still risk having negative effects at all levels of biological organisation long after their initial release into the environment. 2. The ability to determine the ecological risks posed by persistent pollutants remains restricted due to: (1) reliance on standardised toxicology testing on individuals in the laboratory; (2) limited understanding of how spatial and biological variation alters potential ecological effects at population, community and food web levels; and (3) poor knowledge of how pollutant bioaccumulation and biomagnification translate to effects in natural ecosystems. 3. Through global, catchment and reach-scale empirical assessments, this thesis investigated spatial and biological variation, trophic transfers and ecological risk in freshwater ecosystems associated with persistent xenobiotic pollutants (polychlorinated biphenyls [PCBs], polybrominated diphenyl ethers [PBDEs] and organochlorines [OCs]). 4. The transfer, accumulation and magnification of persistent pollutants were related to site-specific environmental conditions, biological traits, food web structure and chemical characteristics, and were sufficient for widespread, hazardous levels of contamination. Across river systems, pollutant body burdens could be linked to putative structural and functional effects that appeared to be networked through food webs. 5. Overall, these data indicate the importance of natural processes in influencing the potential effects of persistent pollutants in freshwater ecosystems. Risk assessments that incorporate the variation present in natural systems are required to improve understanding of the role of xenobiotic pollutants in global environmental change across freshwater ecosystems.
The expression and the role of 5-lipoxygenase in rats of acute liver failure

Objective To investigate the expression and the role of 5-LO, LTB4 in the rats with acute liver failure(ALF). Methods Thirty Wistar rats were divided into 2 groups. Control group(n=6) was given intraperitoneal injection of 0.9% NaCl 2 ml. Model group(n=24) was given joint injection of D-GalN and LPS according to their weight. Six rats were randomly picked respectively after 4,8,16,24 h since modeling and the changes of patholoy and liver function of each rat were dynamic viewed. RT-PCR was used to detect the 5-LO mRNA content variation, WB and IHC-P method were used to detect the 5-LO protein content variation in the reserved hepatic tissues. The ELISA kit was used to detect the content of LTB4 in the liver tissue. Results After administrating D-GalN/LPS, the levels of aminotransferases were increased sig- nificantly(P 0.01) and peaked at 24 h[ALT(3 992.6±290.7)U/L, AST(10 114.7±1 014.2)U/L, T-BIL(32.9±2.0)μmmol/L], and pathological change was in accordance with that of ALF. The expression of 5-LO mRNA in the liver tissue was gradu- ally increased with the development of inflammation and peaked at 8 h after the injection with D-GalN/LPS(P 0.01), then decreased. While the expression of 5-LO protein was continuous increased and peaked at 24 h after modeling. And the level of LTB4 was positively related with the expression of 5-LO in the process of ALF. Conclusion 5-LO and LTB4 participate and play important roles in the pathological processes of ALF.
LARGE-SCALE FIELD TESTS ON IMPULSE WAVES

Reservoirs and other hydropower infrastructure in mountainous areas have to deal with various natural hazards. Iceand rockfalls, landslides as well as rock and snow avalanches may impinge the reservoir, generating impulse waves that may overtop dams. Due to climate change and the rise of the permafrost base, the landslide and rockfall hazard is likely to increase in the future. A reliable risk analysis regarding potential impulse waves is therefore inevitable for the hazard assessment of hydropower infrastructure. The existing computational procedures to calculate wave heights and run-up are mostly based on small-scale model tests and may therefore exhibit scale effects. In addition, the uncertainty of the calculated wave height and run-up is still high. Therefore, new data on impulse wave characteristics were collected using large-scale field tests. A test site was established in a 30 m deep gravel pit. The artificial reservoir was 15 m wide, 55 m long and had a still water depth of 1.5 m. A 40 m long steel ramp along the pit slope (37°) provided a sliding surface. The sliding mass was represented by a steel sledge (3 to 7 tons). The sledge could be released from different ramp positions to vary the impact velocity between 6 and 17 m/s. The resulting wave heights along the wave propagation path and the wave run-up were visually determined using gauge poles. The results help to (1) improve existing computational procedures, (2) determine possible scale effects; and (3) serve as calibration and validation data for numerical modelling of impulse waves.
Approach to the mycological catalogue of the Dehesa of Somosierra and new records for the Community of Madrid (Spain)

An approach to the mycological catalogue of the Dehesa of Somosierra, in the northeast corner of the Community of Madrid, has been carried out. The expeditions were accomplished from April 2013 to October 2015. A total of 96 species were identified belonging to 45 families and 18 orders. To the best of our knowledge, it is the first time that the species as Hyalorbilia inflatula, Panellus serotinus and Vibrissea filisporia f. boudieri have been cited in the Community of Madrid.
ATR-101 phase 1 clinical study for adrenocortical carcinoma.

TPS4585 Background: ATR-101 (Atterocor, Inc., Ann Arbor, MI, USA) is a selective inhibitor of ACAT1 (acyl coenzyme A:cholesterol acyltransferase) in clinical development for the treatment of adrenocortical carcinoma (ACC). ACAT1 catalyzes cholesterol ester formation from cholesterol and long-chain fatty acyl-CoA and, in the adrenals, is particularly important in creating a reservoir of substrate for steroid biosynthesis. ATR-101 selectively distributes to the adrenals, inhibits steroidogenesis and causes apoptosis of cells of the adrenal cortex, as well as in H295R ACC cells. ACC is an ultra-rare malignancy, occurring in about 2 per million population annually. ACC is frequently discovered in Stage 4 and the overall disease survival is approximately 17 months. Tumors often overproduce steroids normally produced in the adrenal cortex and cause therapy-resistant Cushing’s syndrome. Current therapies are toxic, difficult to administer, and poorly effective. Methods: ATR-101-001 is a phase 1 study being condu.
Using Biologics in Inflammatory Arthritis: Assessing the Risks and Benefits

Inflammatory arthritis, such as rheumatoid arthritis (RA), is not simply a disease that affects an individual with symptoms in the present. It also has tremendous impact on the patient’s future well-being. RA has been proposed to be an interrelated triad of disease activity, joint damage, and disability.1 In this triad, current disease activity (pain, swelling, and stiffness of joints) leads to disability and decreased quality of life. Furthermore, disease activity leads to joint damage, which also leads to disability.1 In the modern treatment of inflammatory arthritis, the goal is to not only treat the present symptoms (disease activity) but also, by doing so, to decrease damage and disability and improve quality of life. There is a movement to treat inflammatory arthritis aggressively and early, with the thought that there is a “window of opportunity” in which early intervention can prevent long-term consequences.