Miracle-dz/UniFAR-FTUs huggingface dataset:
SPONTANEOUS CSF OTORRHOEA: REVIEW OF LITERATURE

Spontaneous Leak of Cerebrospinal fluid (CSF) into the middle ear cavity can occur in adults without a history of temporal bone trauma or fracture, meningitis or any obvious cause, it may result from a number of congenital deformities of the ear. Mondini deformity an abnormal development of the cochlea is frequently associated with CSF leakage therefore clues may be lacking that would alert the otolaryngologist that fluid medial to an intact ear drum are fluid emanating from an ear drum perforation is likely to be CSF fluid. Here we are presenting a case of spontaneous CSF leaks in two sites and treated with surgical closure with cartilage graft.
Local extinction risk under climate change in a neotropical asymmetrically dispersed epiphyte

The long‐term fate of populations experiencing disequilibrium conditions with their environment will ultimately depend on how local colonization and extinction dynamics respond to abiotic conditions (e.g. temperature and rainfall), dispersal limitation and biotic interactions (e.g. competition, facilitation or interactions with natural enemies). Understanding how these factors influence distributional dynamics under climate change is a major knowledge gap, particularly for small ranged and dispersal‐limited plant species, which are at higher risk of extinction. Epiphytes are hypothesized to be particularly vulnerable to climate change and we know little about what drives their distribution and how they will respond to climate change. To address this issue, we leveraged a 10‐year dataset on the occupancy dynamics of the endemic orchid Lepanthes rupestris to identify the drivers of local colonization and extinction dynamics and assess the long‐term fate of this population under multiple climate change scenarios. We compared 290 dynamic occupancy models in their ability to predict the colonization and extinction dynamics of a L. rupestris metapopulation. The model set predicted colonization–extinction dynamics as a function of asymmetric patch connectivity, moss area, elevation, temperature (minimum, maximum and variability) and/or rainfall. The best model predicted that local colonization increases with increasing asymmetric patch connectivity but decreases as minimum temperature and maximum temperature variability increase. The best model also predicted that local extinction increases with increasing variability in maximum temperature. Negative effects were more severe in smaller patches. Synthesis. Overall, our results demonstrate the role of asymmetric connectivity, climate and interactions with moss area as drivers of colonization and extinction dynamics. Moreover, our results suggest that asymmetrically dispersed epiphytes may struggle to persist under climate change because their limited connectivity may not be enough to counterbalance the negative effects of increasing mean or variability in temperature.
Discovery of a new tetramethylpyrazine based chalcone with α, β-Unsaturated ketone moiety as a potential anticancer agent

In this study, a new ligustrazine-based chalcone molecule has been synthesized that contains an extra α, β-Unsaturated ketone moiety along with α, the β-Unsaturated carbonyl group of chalone. A new tetramethylpyrazine (TMP) based aldehyde was synthesized to make the TMP (ligustrazine) as part of chalcone and then it was reacted with newly synthesized ketone containing additional α, β-Unsaturated ketone moiety. After characterization, this new compound was evaluated for its effect on different types of cancer cell lines and very promising results were obtained. The growth of these cancer cells was inhibited by newly designed and synthesized compounds, especially for colon and pancreatic cancer cells with IC50 0.04 - 0.05 µM
Heparin Effect On Pulmonary Vascular Remodeling

Received / Geliş tarihi : 21.06. 2016 Accepted / Kabul tarihi : 25.08. 2016 Online published : 24.11. 2016 Elektronik yayın tarihi DOI: 10.12956/tjpd.2016. 261 a component of the vascular remodeling and muscularization seen in pulmonary hypertensive states. Mural vascular changes and narrowing of the vascular lumen increase the resistance to blood flow (2). In animal models of pulmonary hypertension, various drugs have been shown to attenuate pulmonary vascular remodeling (Table I) (1).
Two-pion contributions to the muon g − 2

We perform a detailed analysis of e + e − → π + π − data for energies below 1 GeV, based on a dispersive representation of the pion vector form factor. Using an extended Omnès representation and input for the ππ P -wave phase shift from a previous Roy-equation analysis, we express the pion vector form factor in terms of a few free parameters, which are ﬁt to the modern high-statistics data sets. Statistically acceptable ﬁts are obtained as soon as potential uncertainties in the energy calibration are taken into account. The ﬁts prefer a mass of the ω meson significantly lower than the current PDG average. We perform a complete analysis of statistical and systematic uncertainties and derive the consequences for the two-pion contribution to hadronic vacuum polarization and the muon anomalous magnetic moment a µ . In a global ﬁt, we ﬁnd a ππµ | ≤ 1 GeV = 495 . 0 ( 1 . 5 )( 2 . 1 ) × 10 − 10 and a ππµ | ≤ 0 . 63 GeV = 132 . 8 ( 0 . 4 )( 1 . 0 ) × 10 − 10 . As side products, we obtain improved constraints on the ππ P -wave as well as a determination of the pion charge radius, (cid:104)
Time-optimal trajectory planning for a race car considering variable tyre-road friction coefficients

This paper shows the planning of time-optimal trajectories, which allows an autonomous race car to drive at the handling limits, taking into account locally changing road friction values. For this purpose, the minimum lap time problem is described as an optimal control problem, converted to a nonlinear programme using direct orthogonal Gauss-Legendre collocation and then solved by the interior-point method IPOPT. Reduced computing times are achieved using a curvilinear abscissa approach for track description, algorithmic differentiation using the software framework CasADi, and a smoothing of the track input data by approximate spline regression. The vehicle's behaviour is approximated as a single track and double track model with quasi-steady state tyre load simplification and nonlinear tyre model. The results are used to evaluate which vehicle physics are important for the calculation of the time-optimal trajectory. The novelty of this work is the consideration of wheel-specific tyre-road friction coefficients along the racetrack using a track friction map. It is shown that variable friction coefficients have a significant impact on the trajectory, and therefore significantly improve lap times on inhomogenous racetracks. The proposed trajectory planning has proven its practical suitability in first tests on an autonomous race car and will be used in the coming racing season in the Roborace competition.
A Comparative Study of Conventional Rectifier Topologies for Low Power RF Energy Harvesting

A comparative study among the four commonly used rectifier topologies in literature was presented with the aim of indicating which one yields the maximum RF-to-DC power conversion efficiency for low power RF energy harvesting. For a fair comparison, source-pull simulations were conducted to extract the optimal diode input impedance and to further provide the maximized efficiency for a given RF input power, frequency, and load value. It was shown that, independently of frequency, a single diode topology leads to a better efficiency at low RF powers (< −15 dBm), whereas, a doubler topology provides a larger power dynamics.
Cophylogenetic analysis of the relationship between anemonefish Amphiprion (Perciformes: Pomacentridae) and their symbiotic host anemones (Anthozoa: Actiniaria)

ABSTRACT The association between anemonefish and anemone is a classical example of mutualism in coral reefs. Although mutualism is probably the key innovation that triggered the adaptive radiation of anemonefish into a wide range of habitats, the coevolutionary history between the groups has not been thoroughly tested in a phylogenetic framework. We examined the evolutionary history of the association via distance-based (Parafit and PACo) and event-based methods (Core-PA, Jane). Mitochondrial DNA sequences (COI mtDNA, Cytb, 16S rDNA and 12S rDNA) were used to reconstruct the phylogenies of tropical Amphiprion species and their host anemones by using maximum likelihood with best-fit models selected. Neither distance-based analyses nor event-based analyses revealed global significant congruence between the phylogenies of the hosts and the symbionts, and thus no evidence for coevolution between anemone-anemonefish. However, at the individual pair level, the fish showed some dependence on anemone hosts. Even though living in close association and benefiting from each other, the change of genetic composition of one species (anemonefish) does not always evolve in response to changes in the other (anemones). These findings expand our understanding of the pattern and the role of evolutionary events to allow a better prediction of the future of the anemonefish-anemone relationship.
A Critical Role for Eosinophils and CCR3 Signal Transduction in Allergic Airway Disease

Airway inflammation in asthma is complex, involving innate and adaptive responses, pathologic Th2 sensitization, and alterations in tolerance. In this thesis, we aimed to characterize the contribution of chemokines, CCR3 signal transduction, and eosinophils to experimental asthma. Our studies, implicating the involvement of 17 chemokines in experimental asthma, highlight the complex interaction between numerous chemokines in the setting of allergic airway inflammation. We provide evidence for a murine eosinophil inhibitory pathway mediated by the chemokine CXCL9 (Mig) that potently blocks eosinophil chemoattraction and function by a mechanism dependent on CCR3 and Rac2. Our findings support a new paradigm whereby the major eosinophil chemokine receptor CCR3, previously identified solely as a powerful activating receptor in eosinophils, can transmit positive or negative signals depending upon the ligand engaged. We also demonstrate that eosinophil recruitment into the lung tissue is dependent on CCR3 in two different chronic experimental asthma models. In addition, we provide evidence that airway eosinophilia induced by IL-13 is CCR3and eotaxin-2-dependent. Taken together, these results establish a regulatory chemokine network with the ability to inhibit or recruit particular leukocytes and localize the cells to specific target areas within a tissue utilizing the same chemokine receptor CCR3. To further define the relationship between allergic airway inflammation and the remodeling process, we induced chronic experimental asthma in mice with eosinophil recruitment defects. We reveal a critical role for CCR3 and eosinophils in allergen-induced mucus production and the orchestration of total leukocyte recruitment into the lung lumen. Importantly, we also demonstrate that CCR3-deficiency protects against methacholine-induced airway hyperresponsiveness. In addition, analysis of the reversibility of IL-13-induced chronic inflammation and lung remodeling revealed that while some aspects of chronic airway remodeling are reversible (e.g. mucus cell metaplasia and lung eosinophilia), other important features remain or worsen during the repair process, providing compelling evidence that many of the prominent effects of IL-13 in the lung remain persistent following the initial pathological insult. Collectively, we provide evidence for a central role for CCR3 signal transduction and eosinophils in the development of multiple aspects of allergic airway disease.
SISTEM ZA LOKALIZACIJU OBJEKATA U ROBOTICI

U ovom radu analizirano je projekto­vanje sistema koji je u mogućnosti da detektuje željene objekte u okolini robota, a potom i odredi njihovu loka­ciju. Analizirano je više pristupa rešavanju ovog prob­lema, od korišćenja jednostavnih senzora za deteciju boje, do nešto naprednijih koji uključuju manipulaciju nad slikama i mašinsko učenje. Uređaj je praktično realizovan i prikazani su rezultati uspešnosti za nekoliko metoda, na osnovu čega su izvučeni zaključci. Na kraju su predloženi i dalji koraci koji bi mogli dodatno da poboljšaju rad uređaja.
New Perspectives in Chronic and Neuropathic Pain in Older Population

Chronic and neuropathic pain has always been a major health problem, especially in elderly population. An increasing number of data has demonstrated not only its importance from the physical and psychological point of view, but also for the economic and social aspects [1,2]. For centuries the attention of the researchers was focused on the study of neurons and their functions, initially they explained how pain is transmitted to brain. At the moment the clinicians know almost everything about the ascending and descending systems of pain control. They know about the extremely high number of receptors, from time to time they suggested about the importance in the perception, transmission and reduction of pain. Also the potentiality for therapy and reduction/abolition of pain are increasing in number, but still the number of patients over 65y with moderate to severe pain is increasing. Actually, it is enormous. Looking at the data of recent literature, there is an apparent prevalence of chronic pain of 50% in older adults living on their own, and over 75% in those living in care facilities [3,4]. Moreover, there are many data showing the strict interrelationship of chronic pain with other chronic diseases [5].
Understanding the Processing of Tonal Modulations During Musical Listening Using Behavioural and Neural Techniques

The series of experiments presented in this dissertation elucidates the perceptual and cognitive processing of tonal modulations during musical listening using behavioural measures and electroencephalography (EEG). The purpose of these experiments was to shed light on mechanisms of working memory pertaining to the management of competing activated schemata. The experiments utilized an adaptation of the harmonic priming paradigm typically used in the music cognition literature to study the facilitation of stimulus processing resulting from topdown expectancies generated by a musical stimulus’ tonal structure. Musicians and nonmusicians were presented with extended primes containing two equally represented tonalities, and subsequent targets that were related exclusively to the first tonality presented in the prime, exclusively to the second tonality presented in the prime, or neither tonality. Participants provided subjective judgements of target fit (i.e., “fit” versus “does not fit” with the preceding prime), as well as ratings of the degree of fit using a scale from 1-7. The results of the reaction time analyses generally replicated previous studies of tonal modulations, demonstrating that the activation of an original tonality decays rapidly once a new tonality is introduced, as reaction times were equivalent for targets related to versus unrelated to the original key. However, the
A comparative pharmacognostic evaluation of anatomical and chemical characters of Nardostachys jatamansi (D.Don) DC. (Jatamansa) and Valeriana mooni Arn. ex C.B.Clarke (Lanka thuwarala)

Nardostachys jatamansi (Caprifoliaceae), known as Jatamansa, is an important plant in Ayurveda and traditional medicine in Sri Lanka. The dried rhizome of the plant is an important ingredient in many drugs. This plant does not grow in Sri Lanka. The practice has been to import it from India However, currently its export has been banned as it has become an endangered species in India . An island wide market survey carried out by authors revealed, that the material sold as Jatamansa is substituted by materials other than its recommended substitute, Valeriana wallichii to an extent ranging from 66% to 100%. Substitution with materials other than recommended substitute might adversely affect the efficacy and safety of the drugs manufactured. As V. wallichii also does not grow naturally in Sri Lanka, the present study was carried out to compare pharmacognostic properties of V. mooni the only species of Valeriana found in Sri Lanka with N. jatamansi to evaluate the possibility of replacing N. jatamansi with V. mooni and to establish comparative quality standards of the two plant species which will enable to identify raw material at the point of purchasing. Preliminary phytochemical screening indicated the presence of alkaloids, flavonoids and hydrolysable tannins in both species. The TLC analysis of the ethanol extract of the rhizomes, and GCMS analysis of their essential oils indicated that both species possess similar chemical compounds. The pharmacologically important principal sesquiterpene Jatamansone, was found even in higher amount in V. mooni (25.6%) than in N. jatamansi (8.9%). However clinical trials are needed to decide on the possibility of substituting Indian N. jatamansi with local V. mooni. The findings of the present study have added a new member to the potential list of medicinal plants and identified as an important endangered plant with the need for conservation, hence develop suitable propagation systems and cultivation.
DC SQUID Magnetometry

This thesis describes the measurement of the local magnetic field of a D-Wave Systems Washington generation processor using on-chip multiplexed unshunted DC SQUID magnetometers. These measurements are used in conjunction with passive and active field compensation to minimize the magnetic field present during the superconducting transition of the chip in order to limit the number of magnetic flux lines trapped on chip. This maximizes the operability of the superconducting quantum processor.
Synchronous Voltage Controllers: Voltage-Based Emulation of Synchronous Machines for the Integration of Renewable Energy Sources

Recently, significant attention has been paid to the integration of renewable energy sources into power systems by similar characteristics of synchronous machines (SMs). The conventional method to emulate SMs is to use power components, typically known as power-based virtual synchronous machines (PB-VSMs). This paper looks at the development of a new approach to mimic SMs using voltage components called voltage-based virtual synchronous machines (VB-VSMs). A VB-VSM is a cascaded double-loop controller with current and voltage regulation as opposed to a single-loop PB-VSM. Further, the dynamic model of an automatic voltage regulator (AVR) and a physical rotor field circuit are integrated into the controller. In addition to grid-responsive features, the VB-VSM can also eliminate an extra synchronization unit, typically a phase-locked loop (PLL), as the internal controller acts in a similar fashion to regular PLLs in research literature. Since the controller adopts voltage components for synchronization, control, and emulation purposes, it can be regarded as a synchronous voltage controller (SynVC). Extensive case studies under various conditions are carried out to demonstrate the performance of a SynVC.
Real-Time Vision-Based System of Fault Detection for Freight Trains

Real-time vision-based system of fault detection (RVBS-FD) for freight trains aims to complete routine maintenance tasks efficiently for ensuring railway transportation security. However, most existing systems are designed to detect only one specific type of faults or even one fault, which fail to deal with multifault detection. Recently, the rapid development in deep learning techniques enables systems to provide a robust solution for the RVBS-FD of freight trains. However, general convolutional neural networks (CNNs) cannot fully meet the actual requirements in terms of the real time, accuracy, and resource constrains for the RVBS-FD of freight trains. To solve these problems, we propose a CNN-based detector called Light fault detection network for freight train images (FTI-FDNet) for the RVBS-FD of the freight train. First, we use the multiregion proposal networks (MRPN), which extract a set of prior bounding boxes to achieve initial fault proposal generation. Then, a powerful multilevel region-of-interest (RoI) pooling is presented for proposal classification and accurate detection. We finally design a reliable model reduction scheme (MRS) to pursue fast speed with high detection accuracy in a simple manner. The experimental results on five typical fault benchmarks indicate that our Light FTI-FDNet achieves higher accuracy and fast speed with about 17% model size of the well-known faster region-based CNN (R-CNN) detector, substantially outperforming the state-of-the-art methods.
Ege Üniversitesi Hastanesinde erkek genital sistem kanserlerinin epidemiyolojik ve genel sağ kalım özellikleri

Amac: Ege Universitesi Hastanesi’nde (EUH) Erkek Genital Sistem Kanseri (EGSK) tanisi ile tedavileri yapilan 5.634 kayitli olgunun epidemiyolojik ve genel sag kalim (GSK) ozelliklerini istatistiksel acidan degerlendirmektir. Gerec ve Yontem: Siniflandirmalarda ve sag kalim analizlerinde “Surveillance, Epidemiology, and End Results” (SEER) verileri goz onune alinmistir. CANREG-4 programi ile kaydedilen veriler SPSS programina aktarilmistir. Istatistik analizde Ki-kare yontemi ve dogrusal modellemeler yapilmis ve p<0,05 anlamli kabul edilmistir. Bulgular: EGSK, EUH kanser olgularinin %5,3’ni, erkek kanserlerinin %10,1’ni olusturmaktadir. EGSK’lerinin %84,7’si prostat, %15,3’u ise testis yerlesimlidir. EGSK’lerinin yas gruplarina gore dagiliminda prostat kanserleri en sik 60-69 yas grubunda, testis tumorleri ise 30-39 yas grubunda yer almaktadir. Evrelendirme yapilabilen prostat kanserleri %60,9 lokalize, %20,2 lokal ileri, %16,8 metastatik donemde tani almislardir. Prostat kanserinde yillara gore dogrusal bir artis vardir (p<0,0001), testis tumorunde ise artis saptanmamistir. Prostat kanserlerimizde medyan sag kalim 120 ay, 5 ve 10 yillik genel sag kalim (GSK) oranlari %74,2 ve %55,2’dir. Evrelere gore 5 ve 10 yillik sag kalim oranlari sirasiyla; lokalize evrede %86,3 ve %70, lokal ileri evrede %78,1 ve %62,7, metastatik donemde %21,7 ve %14’tur. Testis tumorlerinde olgularin %45,4’u seminom, %54,6’si nonseminomdur. Testis tumorlerinde 5 ve 10 yillik sag kalimlar sirasiyla %86,6 ve %82,9’dir. Histopatolojiye gore 5 ve 10 yillik GSK sirasiyla; seminomlarda %95,7 ve %94,2, nonseminomlarda ise %80.6 ve %75,2’dir (p<0,001). Sonuc: EUH’de EGSK’lerinin %84,7’si prostat, %15,3’u testis tumorudur. Yillar icinde prostat kanserinde dogrusal artis saptanmis, 5 ve 10 yillik GSK oranlari prostat kanseri icin sirasiyla %74,2 ve %55,2, testis tumorlerinde %86,6 ve %82,9 bulunmustur. Seminomlarda 10 yillik sag kalim %94,2 iken non-seminomlarda %75,2’ye dusmektedir.
Predictors of CD4 cell count response to first-line combination antiretroviral treatment among HIV-positive adult patients from the Asia-Pacific region

This project utilized observational data on HIV-positive patients that was previously collected for the TREAT Asia HIV Observational Databases Low Intensity Transfer (TAHOD-LITE). The study objective was to evaluate the predictors associated with CD4 cell count changes from combination antiretroviral treatment initiation for those who had sought care in 2010-13. The intention was to determine whether certain treatment related and demographic factors could contribute to improved CD4 cell count restoration.