Miracle-dz/UniFAR-FTUs huggingface dataset:
High‐frequency sensorineural hearing loss associated with vestibular episodic syndrome

episodic syndrome Martin-Sanz, E. ,* Esteban, J.,* Vaduva, C. ,* Sanz, R. * & Lopez-Escamez, J.A. *Department ofOtolaryngology,UniversityHospital of Getafe,Madrid, Otology andNeurotologyGroupCTS495,Department ofGenomic Medicine, GENYO Centre for Genomics and Oncological Research Pfizer/University of Granada/ Junta de Andaluc ıa, PTS, Department of Otolaryngology, Complejo Hospitalario Universitario, University of Granada, Granada, Spain
Effects of Arm Cycling Exercise in Spinal Muscular Atrophy Type II Patients: A Pilot Study

Exercise studies in neuromuscular diseases like spinal muscular atrophy (SMA), a devastating disease caused by survival of motor neuron 1 (SMN1) gene mutations, are drawing attention due to its beneficial effects. In this study, we presented a constructed arm cycling exercise protocol and evaluated the benefits on SMA patients. Five SMA type II patients performed 12 weeks of supervised arm cycling exercise. The physical functions were evaluated together with the SMN2 copy numbers, SMN protein levels, insulin-like growth factor 1(IGF1) and binding protein 3 (IGFBP3) levels. The active cycling distance and duration of patients significantly improved. Significant changes could not have detected either SMN or IGF1 and IGFBP3 levels in response to exercise. The findings demonstrated that the patients tolerated the exercise protocol and gained a benefit from arm cycling but benefits could not be associated with SMN2 copy number, SMN protein level, IGF1, or IGFBP3 levels.
Increased level of security using DNA steganography

Security has become one of the important fields of concern when the scenario of information transport is viewed. Cryptology is a traditional technique that hides the message by encoding it. Nevertheless, now it is not only demanded that the data that is being transmitted is encoded, but the very existence of knowledge of data transmission should be concealed. Steganography is thus a technique where the data are not only encoded, but hidden within a carrier. This therefore provides a two-level security. The proposed paper describes a highly secured steganography technique using DNA sequence. The report suggests a technique of hiding an image in an image using DNA sequence.
Eye-motion detection system for mnd patients

This paper aims to develop an eye-motion based communication system for motor neuron disease (MND) patients to contact with care providers any time they want when they lie on the bed. This eye-motion detection system involves technical modules of eye-blink detection, gaze estimation and head pose estimation on MND patients. The system comprises a rotating arm with a camera, an infrared light source and a speaker. The arm with the camera will autonomously rotate to track the face of the patient with arbitrary body directions so that necessary eye detections can be properly conducted when it is called. When the patient needs to call out, only designated blinking and eye motions will trigger the call out action for the need of finding the care provider.
Physicochemical requirements for rapid remineralization of early carious lesions.

Physicochemical data related to remineralization of carious lesions were determined. Diffusion properties of calcium ions, fluoride ions, calcium-anion complexes, and cation-fluoride complexes were studied using protein-impregnated and protein-apatite-impregnated membranes. Stability constants of metal-fluoride and amine-fluoride complexes were determined by titration. Artificial carious lesions were produced in human enamel and immersed in remineralizing solutions containing calcium, zinc, strontium, phosphate, acid anions, fluoride and organic cations at various pH levels. Selected samples were reimmersed in demineralizing solution. Sodium fluoride, acidulated phosphate-fluoride and calcium-phosphate fluoride solutions were tested similarly. Calcium-anion complexes diffused rapidly through protein gels. Metal-fluoride complexes were generally too weak to affect diffusion rates but some cations enhanced fluoride transport. Partial remineralization of lesions occurred with the new test solutions more rapidly than with traditional fluoride preparations, and further demineralization was markedly reduced. Remineralizing solutions based on this new hypothesis show promise as an improved caries preventive measure.
Nonimmune Hydrops fetalis: Fetal and Neonatal Outcome during 1983–1992

Prognostic factors for survival of 62 fetuses and neonates with nonimmune hydrops fetalis (NIHF) were studied retrospectively. Twenty-eight infants survived ≥28 days which is 45% for all fetuses and newborns diagnosed with NIHF and 61% for liveborns with unresolved NIHF. Univariate analysis identified that mortality was associated with the presence of ≥2 serous cavity effusions and a need for chest compressions at birth. Multivariate logistic regression analysis confirmed that the presence of ≥2 serous cavity effusions was significantly associated with mortality from NIHF <28 days after birth [OR = 48.2 (CI 3.6, 662.9) (p < 0.004)]. We conclude that, compared to published cases from the 1970s and early 1980s, survival of liveborns with NIHF seems improved. The decrease in stillbirths is more notable. The severity of hydrops at birth is the key determinant for survival.
How discernible is user impromptu behavior when unlocking a touch screen?

Being a popular computing device, smartphone (or tablet, wearable device) system's screen unlocking mechanisms have recently come under numerous successful attacks. In an aim to deter the attacks, we explored users' spontaneous touch behavioral traits in order to identify the users which we opine could be an added layer of security. We experimented with four conventional unlocking schemes: 4 Digit Pin, 3×3 “Connect the Dots”, Glow Pad, Slide Unlock and proposed one new unlocking mechanism, “Pressure Circle”. Six high-level features have been extracted from user touch activities and we designed our own verifier to identify users. For each unlocking scheme, experimental results generated from 992 impostor attacks performed on 32 user samples, show that users can be identified with an accuracy of up to 77.3% solely by considering their touch behavior. Overall, we achieve an average accuracy of 68.8%. We argue that, this inherent behavioral biometric trait when combined with the conventional unlocking schemes, would be less susceptible to attacks.
Unraveling the Mobilization of Memory in Research With Refugees

In this article, we explore how narrative accounts of trauma are co-constructed through the interaction between researcher and participant. Using a narrative multiple-case study with Kurdish refugee families, we address how this process takes place, investigating how researcher and participants were engaged in relational, moral, collective, and sociopolitical dimensions of remembering, and how this led to the emergence of particular ethical questions. Case examples indicate that acknowledging the multilayered co-construction of remembering in the research relationship profoundly complicates existing deontological guidelines that predominantly emphasize the researcher’s responsibility in sensitively dealing with participants’ alleged autobiographical trauma narratives. Instead, our analysis invites qualitative researchers to engage in a continued, context-specific ethical reflection on the potential risks and benefits that are invoked in studies with survivors of collective violence.
Continuous ambulatory peritoneal dialysis improves immunodeficiency in uremic patients.

F. Giacchino, MD, Nephrology and Dialysis Unit, San Giovanni Hospital, Largo Gottardo 143, I-10154 Turin (Italy) Dear Sir, The high incidence of infections and malignancies in uremic patients [1, 2] is a clear indication of the immuno-suppressive effect of uremia [3–5]. Numerous hypotheses have been put forward, including protein-calorie malnutrition [6], vitamin deficiency [7], and lowered blood zinc levels [8], but so far none of them has proved satisfactory. A more recent suggestion is that serum factors (medium molecular weight) may be responsible for this phenomenon in vitro [9], and in experimental animals [10]. There is still considerable debate however, as to whether middle molecules play a toxic role in cell-mediated immunity in man [11]. In order to evaluate the effect of different degrees of removal of middle molecules by dialysis treatment on cellular immunodeficiency, we analyzed the immunological state of 60 uremic patients treated by continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis (HD) during a follow-up of 12 months. 30 healthy people were also studied as controls. DNCB and PPD skin tests, Eand active Erosettes, the E-rosette inhibition assay were investigated as markers of cellular immunity [12]. The results of our study are summarized in table I. CAPD patients showed an improvement in cellular immunity, with a significant increase in the E-rosette count (p < O.Ol), and improved delayed hypersensitivity reactions 3 months after treatment was started, while no difference was observed in HD patients. The most compelling evidence for a role of middle molecules in cellmediated deficiency has been provided by the E-rosette inhibition test. Serum from CAPD patients showed a significant reduction of the percentage of E-rosette inhibition (p < 0.02), even 1 month after treatment was started, and the results were confirmed at the following controls. In the HD patients the percentage of inhibition remained high throughout our study. Our results are in agreement with previous findings in vitro and in animals [9, 10]. Since CAPD removes middle molecules more satisfactory than hemodialysis [13], and Table I. Cellular immunity in CAPD and HD patients
Regulation of Hed1 and Rad54 binding during maturation of the meiosis‐specific presynaptic complex

Most eukaryotes have two Rad51/RecA family recombinases, Rad51, which promotes recombination during mitotic double‐strand break (DSB) repair, and the meiosis‐specific recombinase Dmc1. During meiosis, the strand exchange activity of Rad51 is downregulated through interactions with the meiosis‐specific protein Hed1, which helps ensure that strand exchange is driven by Dmc1 instead of Rad51. Hed1 acts by preventing Rad51 from interacting with Rad54, a cofactor required for promoting strand exchange during homologous recombination. However, we have a poor quantitative understanding of the regulatory interplay between these proteins. Here, we use real‐time single‐molecule imaging to probe how the Hed1‐ and Rad54‐mediated regulatory network contributes to the identity of mitotic and meiotic presynaptic complexes. Based on our findings, we define a model in which kinetic competition between Hed1 and Rad54 helps define the functional identity of the presynaptic complex as cells undergo the transition from mitotic to meiotic repair.
Optimization of low voltage synchronous reluctance machines using different modulation schemes

This paper presents different possibilities to increase the efficiency and operating range of synchronous reluctance machines in low-voltage traction applications. The maximum power is defined based on the limit of the maximum DC-link voltage level. By using different modulation and control schemes, it is possible to optimize the complete drive train. Moreover, the control schemes will be presented with flow diagrams. Finally, the theory will be approved based on the dynamic and static measurement results.
Cross-Sectional Analysis of Neurological Findings among Healthy Elderly: Study in a Remote Island in Kagoshima, Japan

We have conducted annual health checkup surveys of elderly subjects aged 60 years or older in a remote island of southwestern Japan. After excluding patients with neurological diseases and the subjects who needed help in activities of daily living, a cross-sectional analysis of the data obtained from 348 elderly people aged 60–89 years was made. We examined the age and sex distributions of abnormal neurological findings, including the scores of the Mini-Mental State Examination (MMSE). In this study, aging was associated with muscle weakness in the lower limbs, cerebellar dysfunction, hand tremor, decrease in handgrip, abnormality of deep sensation and a decrease in the MMSE score. These findings suggest a characteristic pattern of nervous system deterioration with age. We discuss the possible pathogenesis and significance of these findings that should contribute to a better understanding of normal aging in the nervous system.
Metabolism of the polysaccharides of human dental plaque. I. Dextranase activity of streptococci, and the extracellular polysaccharides synthesized from sucrose.

An investigation into occurrence of dextranase in human oral streptococci revealed that cell extracts of 8 out of 25 strains contained an enzyme, α-1,6-glucan glucohydrolase, that hydrolyzed the α-(1 → 6)-glucosidic linkages in dextran and isomaltose. Glucose was the only product of low molecular weight released by this enzyme. Six strains contained a different dextranase that released oligosaccharides of the isomaltose series from dextran. In the case of Streptococcus mutans IB16, it was established that the main oligosaccharide products were isomaltotetraose and isomaltopentaose. Cell-free filtrates from 14 of the 25 strains synthesized extracellular polysaccharides from sucrose, and eleven of the filtrates produced water-insoluble glucans. Dextranase occurred in five of the strains that synthesized glucan and in five strains that were unable to synthesize extracellular polysaccharides. All the insoluble glucans were partially hydrolyzed by a fungal α-(1 → 3)-glucanase. None of the cell-extracts or cell-free filtrates was able to hydrolyze α-1,3-glucan.
Review of long-term outcomes of disc arthroplasty for symptomatic single level cervical degenerative disc disease

ABSTRACT Introduction: Cervical disc arthroplasty (CDA) was developed as an alternative for anterior cervical discectomy and fusion (ACDF) for nerve root decompression. The rationale behind CDA was to help prevent adjacent segment degeneration which potentially may lead to additional surgery. Multiple randomized controlled trials have evaluated a myriad of disc arthroplasty devices over the past 10 years and provided data regarding clinical benefits and safety. Their long-term data, reporting results at 5–10 years, presents the opportunity to comment on the overall efficacy, safety and reported complications of these devices. This report reviews results of the Prestige, proDisc-C, Mobi-C Disc and various other arthroplasty devices and provides an overall report of the longest term available data and comparisons between devices. Areas covered: This review summarizes previously published articles in a literature search using keywords: ‘cervical disc arthroplasty’, ‘cervical total disc replacement’, ‘anterior cervical decompression and fusion’, ‘anterior cervical arthrodesis’, ‘symptomatic degenerative disc disease’ and commercial names of devices. Expert commentary: CDA, with the devices reviewed, resulted in favorable outcomes in comparison to ACDF for the treatment of symptomatic cervical degenerative disc disease (DDD) taking in to account the long-term functional recovery, adverse events, development of adjacent segment degeneration and subsequent surgical interventions.
Swedish Prosody

Abstract The paper summarizes project work on Swedish accents and intonation. One major goal was the development of a generative model for intonation. The input of the model is a text with markings for word and sentence prosody and dialect. The output is a realistic intonation contour. The model was first set up for statement intonation in isolated sentences from five prototype dialects. It was later applied to interrogative intonation, to transitional forms between the prototype dialects, to Greek and French intonation and to prosodic transfer in a foreign accent.
The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles

The dense-core vesicle is a secretory organelle that mediates the regulated release of peptide hormones, growth factors, and biogenic amines. Dense-core vesicles originate from the trans-Golgi of neurons and neuroendocrine cells, but it is unclear how this specialized organelle is formed and acquires its specific cargos. To identify proteins that act in dense-core vesicle biogenesis, we performed a forward genetic screen in Caenorhabditis elegans for mutants defective in dense-core vesicle function. We previously reported the identification of two conserved proteins that interact with the small GTPase RAB-2 to control normal dense-core vesicle cargo-sorting. Here we identify several additional conserved factors important for dense-core vesicle cargo sorting: the WD40 domain protein EIPR-1 and the endosome-associated recycling protein (EARP) complex. By assaying behavior and the trafficking of dense-core vesicle cargos, we show that mutants that lack EIPR-1 or EARP have defects in dense-core vesicle cargo-sorting similar to those of mutants in the RAB-2 pathway. Genetic epistasis data indicate that RAB-2, EIPR-1 and EARP function in a common pathway. In addition, using a proteomic approach in rat insulinoma cells, we show that EIPR-1 physically interacts with the EARP complex. Our data suggest that EIPR-1 is a new component of the EARP complex and that dense-core vesicle cargo sorting depends on the EARP-dependent retrieval of cargo from an endosomal sorting compartment. Author Summary Animal cells package and store many important signaling molecules in specialized compartments called dense-core vesicles. Molecules stored in dense-core vesicles include peptide hormones like insulin and small molecule neurotransmitters like dopamine. Defects in the release of these compounds can lead to a wide range of metabolic and mental disorders in humans, including diabetes, depression, and drug addiction. However, it is not well understood how dense-core vesicles are formed in cells and package the appropriate molecules. Here we use a genetic screen in the microscopic worm C. elegans to identify proteins that are important for early steps in the generation of dense-core vesicles, such as packaging the correct molecular cargos in the vesicles. We identify several factors that are conserved between worms and humans and point to a new role for a protein complex that had previously been shown to be important for controlling trafficking in other cellular compartments. The identification of this complex suggests new cellular trafficking events that may be important for the generation of dense-core vesicles.
System identification acceleration and improvement with genetic programming usage

Identification of controlled system is a known and necessary task in proper controller design and its adaptation. In all cases, system identification is also a needed procedure for assessment of the nature of the systems and for the simulation proposes. Presented system identification is based on the difference equation parameters finding (optimization) with the usage of the genetics algorithms. The only disadvantage of the proposed method could be the computing time, which can be too long for real applications, when it is necessary to be really precise. One of the factor, which influences the computing time is the number of input-output data. The acceleration and improvement of the proposed method is done by the taking into the account the number of the data, which is necessary for the sufficiently precise identification of the system.
Haptoglobin and abnormal haemoglobin types in Sinhalese and Punjabis.

Phenotype frequencies and gene frequencies of haptoglobins and haemoglobins were assessed in Sinhalese and Punjabis, two quite different populations of the Indian subcontinent. A clinical component, a latitudinal gradient, may be discerned in the great range of Hp1 gene frequencies that occurs in India. Haptoglobin and heamoglobin gene frequencies are compatible with but do not give clear proof of a more northerly origin of the Sinhalese.
Significance of Early CT Signs in Acute Stroke

Objective: To study the pathophysiology of early CT signs. Background: Early CT signs, due to an increase in tissue water content, are commonly attributed to cytotoxic edema and development of irreversible injury. This may have important implications for thrombolysis. Methods: In patients with acute ischemic stroke in the middle cerebral artery territory, the areas of early CT signs and diffusion weighted imaging (DWI) hypersignal were independently assessed and drawn on a standardized atlas. Then, patients were classified into three groups (early CT signs larger than, similar to or smaller than DWI hypersignal) and compared with perfusion weighted imaging (PWI). Results: Of 16 patients, CT scanning was performed with a median time of 3 h after onset and early CT scan signs were recorded in 10/16 patients (62.5%). DWI signal hyperintensity was present in 15/16 (94%) patients. In 7/16 (43%) patients, the area with early CT scan signs was larger than the DWI lesion (‘CT-larger group’). Only in 2/16 (12%) patients were the areas matching (‘matching group’). In 7/16 (43%) the DWI lesion was larger than the early CT scan signs area (‘DWI-larger group’). When compared with PWI, the areas of early CT signs were larger than DWI hypersignal and were matching with PWI abnormalities (rMTT) in 2 cases, suggesting that they may represent a reversible process. Conclusions: Early CT signs might have a potential dual fate: infarction or reversibility. Other techniques of recognizing reversible ischemic damage, such as DWI-PWI, are needed to improve acute stroke diagnosis and management.
Adaptive Denoising and Multiscale Detection of the V Wave in Brainstem Auditory Evoked Potentials

This paper describes a wavelet-transform-based system for the V wave identification in brainstem auditory evoked potentials (BAEP). The system combines signal denoising and rule-based localization modules. The signal denoising module has the potential of effective noise reduction after signal averaging. It analyses adaptively the evolution of the wavelet transform maxima across scales. The singularities of the signal create wavelet maxima with different properties from those of the induced noise. A non-linear filtering process implemented with a neural network extracts out the noise-induced maxima. The filtered wavelet details are subsequently analysed by the rule-based localization module for the automatic identification of the V wave. In the first phase, it implements a set of statistical observations as well as heuristic criteria used by human experts in order to classify the IV–V complex. At the second phase, using a multiscale focusing algorithm, the IV and V waves are positioned on the BAEP signal. Our experiments revealed that the system provides accurate results even for signals exhibiting unclear IV–V complexes.