Miracle-dz/UniFAR-FTUs huggingface dataset:
Flexion and anterior knee pain after high flexion posterior stabilized or cruciate retaining knee replacement.

BACKGROUND Special high-flexion prosthetic designs show a small increase in postoperative flexion compared to standard designs and some papers show increased anterior knee pain with these prosthesis. METHODS A prospective double blind randomized controlled trial investigates the difference in flexion and anterior knee pain between standard and high-flexion total knee arthroplasty. In total 47 patients were randomly allocated to a standard cruciate retaining fixed bearing design (CR) in 23 patients and to a high-flexion posterior stabilized mobile bearing design (HF-PS) in 24 patients. RESULTS The HF-PS did show a significantly higher passive postoperative flexion; 120.8° (SD 10.3°) vs. 112.0° (SD 9.5°) for the CR group (p = 0.004). The active postoperative flexion, VAS-pain score and Feller score did not show significant differences between both groups. Sub analysis with the HF-PS group showed a higher VAS-pain for the patients achieving ≥130° of flexion; 30.5 (SD 32.2) vs. 12.2 (SD 12.5) (p = 0.16). CONCLUSION The present study showed a significant higher passive flexion in the high-flexion prosthesis compared to the standard prosthesis. However this difference disappeared when comparing active flexion. No difference in anterior knee pain was found between both groups.
Graphene for antenna applications: Opportunities and challenges from microwaves to THz

The use of graphene for antennas and other electromagnetic passives could bring significant benefit such as extreme miniaturization, monolithic integration with graphene RF nanoelectronics, efficient dynamic tuning, and even transparency and mechanical flexibility. Though recently different related theoretical works have been presented, relatively few applications have been proposed and realistically assessed. In this invited talk we will briefly review the main properties of graphene and the state of the art in its theoretical and experimental characterization. Then, we will discuss a number of potential antenna applications from microwave to THz, providing in each case a critical assessment of the benefits, limitations, and remaining issues towards actual real-life implementations. Here we provide a brief overview of different devices and associated developments in our group discussed in the talk, including graphene antennas and reflectarrays at microwave and THz, plasmonic switches, isotropic and anisotropic meta-surfaces, or graphene RF-NEMS.
Translation, History and Culture

Introduction - Proust's grandmother and the "Thousand and One Nights" the "cultural turn" in translation studies translation - its genealogy in the West translation, text and pre-text "adequacy" and "acceptability" in cross-cultural communication translation and the consequences of scepticism translation in oral tradition as a touchstone for translation theory and practice translation, colonialism and poetics - Rabindranath Tagore in two worlds culture as translation linguistic polyphony as a problem in translation linguistic transcoding or cultural transfer? - a critique of translation theory in Germany theorizing feminist discourse/translation translation and the mass media translating the will to knowledge - preface and Canadian literary politics translation as appropriation - the case of Milan Kundera's "The Joke".
The nutrition evaluation of kidney beans (Phaseolus vulgaris). The effect of nutritional value of seed germination and changes in trypsin inhibitor content.

The total N content of kidney beans (Phaseolus vulgaris) was found to increase on germination. The overall amino acid composition however changed very little. Rats fed on a diet containing raw beans lost more weight than the protein-free controls (negative n.p.u. value). Germination was found to bring about a gradual improvement in nutritive value probably through the elimination of some of the toxic constituents of the seed. The near doubling of the amount of trypsin inhibitors by the 8th day of germination taken together with the substantial improvement in the nutritive value of the bean appeared to rule out trypsin inhibitors as the main toxic components of raw beans.
Expression of cellular oncogenes in human gastric carcinoma: c‐myc, c–erb B2′ and c‐Ha‐ras

Expression of oncogenes in gastric cancer tissue was evaluated with immu‐nohistochemical staining methods using monoclonal antibodies to products of the oncogenes. Rates of expression in gastric cancer tissue were 50% for c‐myc, 72% for c‐erb B2, and 56% for c‐Ha‐ras oncogenes. Expression of these oncogenes in gastric cancer was not correlated with the histologic differentiation. The c‐Ha‐ras oncogene was positive in 19 of 26 cases with lymph node and/or distant metastasis: the positive rate was significantly higher than in cases without metastasis. Results suggest that c‐Ha‐ras oncogene is related to the prognosis of gastric cancer. The rate of expression of c‐myc and c‐Ha‐ras oncogenes in gastric cancer tissues was higher in the DNA aneuploid group than in the DNA diploid group. Expression of c‐myc and c−Ha−ras oncogenes correlated with other prognostic factors such as DNA ploidy pattern and metastasis. These oncogenes can be used to evaluate prognosis of gastric cancer patients. © 1993 Wiley‐Liss, Inc.
Innovative web 2.0 implementation: a case study of a web 2.0 technology proliferation within a university setting

This study examines the chronological use of web 2.0 technologies within a university setting with the goal of strengthening the level of community communication, interaction and collaboration. We provide an analysis of the structural potential of web 2.0 technologies, and their practical usage as a key determinant of the technology's impact on a specific organisation, as well as an analysis of its significance pertaining to Information Systems (IS) research. The role of web 2.0 usage to bring about organisational change is analysed through the lens of Adaptive Structuration Theory (AST).
Contribución a la validación de sistemas complejos tolerantes a fallos en la fase de diseño. Nuevos modelos de fallos y técnicas de inyección de fallos.

En el diseno de sistemas informaticos (y en particular, de aquellos en los que, por las caracteristicas del servicio que prestan, un mal funcionamiento puede provocar perdida de vidas humanas, perjuicio economico, suspension de servicios primordiales, etc.), se establece como prioridad esencial conseguir que funcionen correctamente durante el mayor tiempo posible y con un elevado nivel de eficacia. Los sistemas que regulan servicios criticos disponen de unos mecanismos especiales que les proporcionan una cierta inmunidad a la ocurrencia de averias que puedan causar un cese o deterioro del servicio prestado. Por ello, se les denomina Sistemas Tolerantes a Fallos, o STF. Se define el concepto de Confiabilidad como un conjunto de funciones (o atributos) que permiten cuantificar la calidad del servicio prestado en cuanto a averias producidas, y en consecuencia, el grado de confianza que el usuario puede depositar en el sistema. Al desarrollar cualquier sistema tolerante a fallos es preciso validarlo, o lo que es lo mismo, cuantificar sus parametros de Confiabilidad. Entre los numerosos metodos y tecnicas existentes para validar sistemas tolerantes a fallos, esta tesis se ha centrado en un metodo de validacion experimental: las tecnicas de inyeccion de fallos basadas en la simulacion de modelos en VHDL. Las principales ventajas de este conjunto de tecnicas son que se pueden aplicar en la fase de diseno del sistema y que permiten acceder a cualquier elemento del modelo del sistema. Por contra, presentan el inconveniente de que, sobre todo en modelos de sistemas complejos, la inyeccion de los fallos supone un elevado coste temporal. Sin embargo, sus importantes ventajas las hacen lo suficientemente atractivas como para ser utilizadas al menos como tecnica complementaria de otras mas utilizadas por su bajo coste y sencillez de implementacion, como SWIFI (software implemented fault injection). Un aspecto muy importante de las tecnicas de inyeccion de fallos mediante simulaci
Behavioral deviance in 13-year-old twins: an item analysis.

Abstract A genetic study of behavioral deviance in 285 pairs of 13-year-old twins is described. Parents and teachers completed standardized questionnaires on the total sample. Concordance rates for monozygotic and dizygotic twins with respect to individual items of behavior, as well as antisocial and neurotic subscale scores, were calculated to produce an estimate of the genetic contribution to etiology of deviance. It is concluded that genetic influences are greatest for items relating to overactivity, inattention, and lack of concentration but are present to a less certain degree for a range of neurotic, antisocial, and psychosomatic behavior items.
Enhanced Expression of Interleukin (IL)-1 and IL-6 Messenger RNA and Bioactive Protein after Hypoxia-Ischemia in Neonatal Rats

The effect of hypoxia-ischemia (HI) on IL-1, and IL-6 bioactivity in relation to expression of IL-1α, IL-1β, and IL-6 mRNA was studied, and the neuroprotective efficacy of IL-1 receptor antagonist (IL-1ra) was evaluated in neonatal rats. HI was induced in 7-d-old rats by unilateral carotid artery ligation and hypoxia for 70-100 min. Animals were killed at different time points up to 14 d after HI, and brains were analyzed for IL-1 and IL-6 bioactivity using bioassays and for mRNA for IL-1α, IL-1β, and IL-6 with reverse transcription followed by a polymerase chain reaction. In separate animals, IL-1ra was administered intracerebrally before or after HI, and the extent of brain injury was assessed 14 d after HI. A transient increase of IL-1 bioactivity occurred after HI, reaching a peak at 6 h of recovery. IL-1β mRNA followed a similar time course but attained maximum expression at 3 h. IL-6 bioactivity and mRNA were also stimulated by HI and followed a similar time course as IL-1. Pretreatment with IL-1ra reduced HI brain damage from 54.5 ± 9.3 to 41.4 ± 10.0% (p ≤ 0.01), and IL-1ra posttreatment increased the proportion of animals devoid of brain injury (40%) compared with vehicle-treated controls (13%) (p≤ 0.05). In conclusion, a transient activation of IL-1 and IL-6 occurred after HI, and IL-1ra reduced HI brain injury to a moderate degree.
Securing Distributed SDN Controllers against DoS Attacks

Software-defined networking (SDN) is an agile and flexible computer network architecture that allows a quick and efficient response by the network administrator to any changes. A Distributed SDN Controllers architecture is more effective and scalable with higher availability. This paper proposes a distributed controller approach to detect Denial of Service (DoS) attacks in SDN network and recover attacked controller. To address DoS attacks efficiently, the approach proposes a protocol with several components including a mapping algorithm, heart-beat messages, synchronization messages, take-over process, and protective mode. Besides the DoS attack, the proposed approach addresses several concerns that come with it. The proposed approach has been applied and tested on mininet simulator.
itochondrial mutant cells are hypersensitive to ionizing radiation , phleomycin nd mitomycin

Mitochondrial DNA (mtDNA) is an important contributor to the ATP-generating oxidative phosphorylation complex. Single nucleotide mutations in mitochondrial genes involved in ATP synthesis result in a broad range of diseases. Leber optic atrophy and Leigh’s syndrome are two such diseases arising from point mutations in the mitochondrial genome. Here, ionizing radiation, phleomycin and mitomycin C (MMC) were used to induce structural chromosomal aberrations in Leber’s and Leigh’s cells to investigate how these mitochondrial mutations affect the cell’s DNA repair processes. Because of the energy deprivation that results from mitochondrial mutations, we hypothesized that these mutant cells would demonstrate hypersensitivity when exposed to oxidative and genotoxic stress and we also expected that these cells would not be able to repair nuclear DNA damage as efficiently as normal cells. As a consequence, these mutant cells are expected to show increased levels of DNA damage, longer cell cycle delays and increased levels of cell death. Following acute radiation exposure these mutant cells showed an increase in the number of chromosomal aberrations and decreased mitotic indices when compared with normal human lymphoblastoid cells with wild-type mtDNA. When exposed to phleomycin or MMC, the mitochondrial mutant cells again showed hypersensitivity and decreased mitotic indices compared to normal cells. These results suggest that Leber’s and Leigh’s cells have an impaired ability to cope with oxidative and genotoxic stress. These observations may help explain the role of ATP generation in understanding the enhanced sensitivity of mitochondrial mutant cells to cancer therapeutic agents and to adverse environmental exposure, suggesting that individuals with mtDNA mutations may be at a greater risk for cancer and from other diseases that result
Face Recognition Based On Vector Quantization Using Fuzzy Neuro Clustering

— A face recognition system is a computer application for automatically identifying or verifying a person from a digital image or a video frame. A lot of algorithms have been proposed for face recognition. Vector Quantization (VQ) based face recognition is a novel approach for face recognition. Here a new codebook generation for VQ based face recognition using Integrated Adaptive Fuzzy Clustering (IAFC) is proposed. IAFC is a fuzzy neural network which incorporates a fuzzy learning rule into a competitive neural network. The performance of proposed algorithm is demonstrated by using publicly available AT&T database, Yale database, Indian Face database and a small face database, DCSKU database created in our lab. In all the databases the proposed approach got a higher recognition rate than most of the existing methods. In terms of Equal Error Rate (ERR) also the proposed codebook is better than the existing methods.
Development of basic medical sciences in a new medical school with an integrated curriculum: The ANU experience

Background: The development of a basic medical science curriculum in a new medical school with a problem-based focus in Australia has been subject to a number of constraints. We describe the process and early evaluation. Aim: To describe the development of a basic medical science curriculum in an Australian medical school with a problem-based curriculum. Methods: We describe the process we used for curriculum development and the benefits and constraints that arose from pre-existing strong biomedical science on the Australian National University (ANU) campus. We outline methods we used to inform our curriculum content and report on accreditation and early internal evaluation. Results: Australian medical schools design their curriculum within a relatively restrictive framework put forward by a national accreditation system. The curriculum achieved accreditation from the external accrediting agency, but early student evaluation has been mixed. Conclusion: Although our internal faculty evaluation and external review by the accrediting agency has supported the view that this aspect of the curriculum has performed reasonably well, student feedback is mixed and further evaluation is needed and adjustments probably warranted.
Data association approach to mobile robot localization using non-unique landmarks

In global localization problem, the robot should localize itself without the knowledge of its initial pose, i.e., its initial position and attitude. Under GPS-denied environment, non-unique landmarks such as traffic signs can be used as alternative absolute position information. However, such landmarks lead to ambiguous correspondence between landmarks and their features. For a robot to successfully localize itself, this ambiguity should be tackled. To solve the problem, a multiple hypothesis testing method is adopted. As robot detects other landmarks, the number of the hypotheses can be increased exponentially. The nearest neighbor filter technique is applied to prevent the number increase. The capability of the suggested algorithm is examined based on a computer simulation.
Critical evaluation of comparative model building of Streptomyces griseus trypsin.

The X-ray crystal structure of Streptomyces griseus trypsin has been solved and refined at 1.7-A resolution. The structure of this protein had been predicted in two models on the basis of its expected homology to structures of bovine trypsin and other pancreatic serine proteases [Jurásek, L. , Olafson, R.W. , Johnson, P., & Smillie, L.B. (1976) Miami Winter Symp. 11, 93-123; Greer, J. (1981) J. Mol. Biol. 153, 1027-1042]. An evaluation of these models in light of the known structure demonstrates the effect of several sources of error on such comparative model building. The objective of comparative model building is often to explain substrate specificity, or to suggest potential highly specific drugs. The unique parts of modeled proteins that are most important for such purposes are, however, the most poorly determined by the model-building procedure.
Comparison of Directly Determined and Calculated Plasma Bicarbonate Concentration in the Turtle Chrysemys Picta Bellii at Different Temperatures

In any study on the effects of changes in body temperature on acid-base status of ectotherms, the relationship between temperature and plasma bicarbonate is of central interest. Many such studies report that arterial pH varies inversely with temperature (see reviews by Howell & Rahn, 1976; Reeves&Rahn, 1979; Jackson, 1982); in air-breathing vertebrates, this is often exclusively caused by a rise in blood PcO2 with body temperature. In contrast, total CO2 (CCO2) and thus bicarbonate concentration of the plasma remain essentially constant with changes in temperature. Other studies report a departure from this pattern with bicarbonate concentrations changing significantly with temperature (Bennett, 1973; Wood, Glass &Johansen, 1977; Nolan & Frankel, 1982). However, in most studies on acid-base balance in reptiles, bicarbonate concentration has not been measured directly but has been calculated from the Henderson-Hasselbalch equation:
Synchronous Optimal Pulsewidth Modulation for Low-Switching-Frequency Control of Medium-Voltage Multilevel Inverters

This paper presents the mechanism and details of synchronous optimal pulsewidth modulation (PWM) generation for control of medium-voltage induction motor drives using multilevel inverters at low switching frequency. Multilevel inverters allow operation at multiple of dc-link voltage and reduce the total harmonic distortion (THD). Synchronous optimal PWM control permits setting the maximum switching frequency to a low value without compromising THD. Low switching frequency reduces the switching losses of the power semiconductor devices. An optimal control procedure is explained in detail. The performances of three- and five-level inverter topologies are compared. The experimental results of a five-level inverter drive using optimal PWM control are presented.
Preparations for unrelated donor transplantation

This mini-review briefly describes some of the issues that are important for a transplant physician preparing a patient for an unrelated donor (UD) stem cell transplant. It is primarily directed at referring hemato-oncologists and trainees in transplantation and aims to provide them with the information they require to deal with these patients appropriately and efficiently. It discusses search strategies, the need for urgency and early identification of the major problems that will determine the outcome of the transplant. Excellent communication with the histocompatibility and immunogenetics laboratory and the referring physician are emphasized. Many of the recommendations are derived from personal experience; there is a need for more of an evidence base to aid decision-making.
Solutions de viscosité des équations de Hamilton-Jacobi

Le but de ce livre est de presenter la theorie des solutions de viscosite pour les equations de Hamilton-Jacobi du premier ordre et ses applications aux problemes de controle optimal deterministe et de perturbations singulieres, en particulier du type Grandes Deviations. Il est principalement destine aux etudiants de troisieme cycle et aux chercheurs qui souhaitent se familiariser avec cette theorie mais il en fournit egalement un panorama assez complet pour les equations du premier ordre.
Molecular Mechanisms of Tenofovir Resistance Conferred by Human Immunodeficiency Virus Type 1 Reverse Transcriptase Containing a Diserine Insertion after Residue 69 and Multiple Thymidine Analog-Associated Mutations

ABSTRACT Two amino acids inserted between residues 69 and 70 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) are rare mutations that may develop in viruses containing multiple thymidine analog (zidovudine [AZT], stavudine)-associated mutations and that confer high-level resistance to all currently approved chain-terminating nucleoside and nucleotide RT inhibitors (NRTIs). The two known mechanisms of resistance to NRTIs are decreased incorporation and increased excision. The mechanism used by RT insertion mutants has not been described for tenofovir (TFV), a recently approved agent in this class. A patient-derived HIV-1 strain (strain FS-SSS) that contained an insertion mutation in a background of additional resistance mutations M41L, L74V, L210W, and T215Y was obtained. A second virus (strain FS) was derived from FS-SSS. In strain FS the insertion and T69S were reverted but the other resistance mutations were retained. The FS virus showed strong resistance to AZT but low-level changes in susceptibilities to other NRTIs and TFV. The FS-SSS virus showed reduced susceptibilities to all NRTIs including TFV. Steady-state kinetics demonstrated that the relative binding or incorporation of TFV was slightly decreased for FS-SSS RT compared to those for wild-type RT. However, significant ATP-mediated excision of TFV was detected for both mutant RT enzymes and followed the order FS-SSS RT > FS RT > wild-type RT. The presence of physiological concentrations of the +1 nucleotide inhibited TFV excision by the wild-type RT and slightly inhibited excision by the FS RT, whereas the level of excision by the FS-SSS RT remained high. Computer modeling suggests that the increased mobility of the β3-β4 loop may contribute to the high-level and broad NRTI resistance caused by the T69 insertion mutation.