Miracle-dz/UniFAR-FTUs huggingface dataset:
Programa en red para la reperfusión del infarto con telemedicina

Fil: Silberstein, A. Hospital de Alta Complejidad en Red El Cruce Dr. Nestor C. Kirchner. Servicio de Cardiologia. Florencio Varela, Argentina. Fil: de Abreu, M. Hospital de Alta Complejidad en Red El Cruce Dr. Nestor C. Kirchner. Servicio de Cardiologia. Florencio Varela, Argentina. Fil: Mariani, J. Hospital de Alta Complejidad en Red El Cruce Dr. Nestor C. Kirchner. Servicio de Cardiologia. Florencio Varela, Argentina. Fil: Kyle, D. Hospital de Alta Complejidad en Red El Cruce Dr. Nestor C. Kirchner. Servicio de Cardiologia. Florencio Varela, Argentina. Fil: Gonzalez Villa Monte, G. Hospital de Alta Complejidad en Red El Cruce Dr. Nestor C. Kirchner. Servicio de Cardiologia. Florencio Varela, Argentina. Fil: Sarmiento, R. Hospital de Alta Complejidad en Red El Cruce Dr. Nestor C. Kirchner. Servicio de Cardiologia. Florencio Varela, Argentina. Fil: Tajer, C. Hospital de Alta Complejidad en Red El Cruce Dr. Nestor C. Kirchner. Servicio de Cardiologia. Florencio Varela, Argentina.
THU0138 Das 28 correlated poorly with the objective evidence of inflammation as detected by ultrasound (US) examination of hands and feet in patients with established rheumatoid arthritis (RA)

Background The Disease Activity Score including 28 joint count (DAS-28) is the most widely used outcome measure in RA. However, despite evidence that metatarsophalangeal (MTP) joints are often the first joints affected in RA, DAS-28 score does not incorporate them. Objectives Our study aimed to investigate the correlation between DAS-28 assessment and objective evidence of active joint inflammation using the US examination of both hands and feet, including wrists, metacarpophalangeal (MCP), proximal interphalangeal (PIP), and MTP joints. Methods A retrospective study was conducted, including 87 patients who were referred to the US clinic for an examination of their hands and feet in the last 6 months (46 patients with RA and 43 controls - patients with other inflammatory or degenerative arthropathies). Information about demographics, disease duration, current treatment, inflammatory markers, and DAS-28 scores was captured. The US OMERACT criteria were used for grading synovial hypertrophy, and assessing for the presence of Power Doppler (PD) signal, erosions and osteophytes. Statistical analysis methods included T-test, Mann-Whitney U test, Z score for proportions and Spearman's correlation coefficients. Results In the RA group, DAS-28 had a weakly positive correlation with the cumulative PD scores of their hands and feet joints (R=0.14, P=0.02), but did not correlate with PD score of MTP joints (R=0.03, P=0.09). In the control group, DAS-28 did not correlate significantly with either the total PD scores of feet (R=0.42, P=0.26) or hands and feet joints (R=0.5, P=0.25). Sensitivity of US examination of hands alone compared to hands and feet was 74.3% for the RA group, while the sensitivity of US feet to detect the presence of PD was 59.2% when compared to the US of both hands and feet. Conclusions We found that DAS-28 correlated poorly with objective evidence of inflammation as detected by US of the hands and feet, and this correlation was lost when only the presence of inflammation in the feet was taken into consideration. Further validation of our results in a larger study including patients stratified based on the disease duration might help understand which patient subgroups are more likely to have their disease activity significantly under-evaluated using DAS-28 outcome measure. Disclosure of Interest None declared
A multi-genre model for music emotion recognition using linear regressors

ABSTRACT Making the link between human emotion and music is challenging. Our aim was to produce an efficient system that emotionally rates songs from multiple genres. To achieve this, we employed a series of online self-report studies, utilising Russell's circumplex model. The first study (n = 44) identified audio features that map to arousal and valence for 20 songs. From this, we constructed a set of linear regressors. The second study (n = 158) measured the efficacy of our system, utilising 40 new songs to create a ground truth. Results show our approach may be effective at emotionally rating music, particularly in the prediction of valence.
Borsa İstanbul ile Türkiye nin Yüksek Dış Ticaret Hacmine Sahip Ülke Borsalarının Entegrasyonu: Rejim Kaymalı Eşbütünleşme Analizinden Bulgular (Integration of BIST and Stock Exchanges of Countries Having High Foreign Trade Volumes with Turkey: Empirical Evidence from Regime Shift Cointegration Anal

Bulgular – Dickey-Fuller (ADF;1981), Phillips-Perron (PP;1988) ile Lee ve Strazicich (2003) birim kök testi sonuçlarına göre serilerin bütünleşme dereceleri I(1) olarak belirlenmiştir. Hatemi-J (2008) yapısal kırılmalı eşbütünleşme testi BIST100 ile DAX 30, FTSE 100, IMOEX, CAC 40 ve S&P 500 arasında uzun dönemli bir ilişkinin olduğunu, fakat FTMIB ve IBEX ile uzun dönemli bir ilişki bulunmadığını göstermektedir.
A study on influence of education and occupation on family planning practices in rural Shamirpet, R.R. District, T.S., India.

Family planning is an important pillar for safe motherhood and good reproductive health and is influenced by number of socio-demographic factors. Since fertility in India is primarily marital this study was planned among married women. A community based cross-sectional study was conducted among 402 women of reproductive age group. Details regarding various socio-demographic factors with special emphasis on education and occupation of husband and wife and their socio-economic status and its relation to contraceptive usage were studied. Prevalence of contraception was found to be 61.7%. Contraceptive usage had a significantly positive relation with literacy status of women, socio economic status of the couple. On the other hand husband’s educational status, occupation of women, husband’s occupation did not have any relation with contraceptive usage.
A Full Field-of-View Self-Steering Beamformer for 5G mm-Wave Fiber-Wireless Mobile Fronthaul

The upcoming new radio access allows ultra-high data rate using millimeter-wave (mm-Wave) frequencies, while it normally suffers from large path loss. To compensate for path loss, phased arrays for both the transmitter and receiver are used. The 5G new radio (NR) three beam management process proceeds as follows: The transmitted beam is first swept in the downlink direction from the remote radio unit (RRU) to the user equipment (UE), and then the uplink beam is aligned to determine which beam direction has the best reception quality, and vice versa. However, this sequential beam management requires that the RX must be able to perform both beam detection and steering across all the reception angles. Moreover, due to the narrow beamwidth of the phased array operation, a “quantum leap” performance improvement of the receiver operating at mm-Wave is required. In this article, a self-steering array beamformer (SSA-BF) receiving system is proposed, which is composed of a home-designed IC package with zero DC power consumption and a 4-element antenna array. We first conduct the measurement without the antenna, and the SSA-BF receiver shows a significant array factor enhancement with negligible SNR degradation over full field-of-view (FoV) (incidence angle = ±90°), <3 ms fast beam alignment time, and it can support enhanced mobile data-rate up to 10 and 7.8 Gb/s with 20x100 MHz carrier aggregation OFDM in back-to-back and over 25-km fiber transmission, respectively. Moreover, a broadside 3-dB beamwidth ±80° and broadband 17-36 GHz antenna is designed for the proposed SSA-BF receiver in a 5G fiber-wireless access. The SSA-BF receiving system with the 1 × 4 antenna array is designed at 28 GHz, and it shows the normalized array gain better than 3- and 6-dB degradation over broad FoV incidence = ± 68° and ± 85°, respectively. Without any external tuning controls, the proposed SSA-BF achieves the state-of-the-art autonomous beamforming for 6 Gb/s 64-QAM signal over 50-cm wireless distance, achieving a substantial array factor improvement. To the best of authors’ knowledge, this is the first demonstration of a high-speed switching SSA-BF receiver in a fiber-wireless integrated radio access as a true enabler for mm-Wave mobile fronthaul applications
The Ontario Structures of Care in Colorectal Cancer Surger Study (OSCRC): Assessing Hospital Level Variation and Impact on Short Term Patient Outcomes

HOSPITAL-LEVEL STRUCTURES OF CARE AND SHORT TERM OUTCOMES OF COLORECTAL CANCER SURGERY Rahima N. Nenshi Masters of Science 2009 Graduate Department of Health Policy, Management and Evaluation University of Toronto Introduction: Surgical treatment is the cornerstone of the management of colorectal cancer (CRC). This study described the structures of care at Ontario hospitals performing CRC surgery. Methods: Patients diagnosed with CRC undergoing surgery were identified from 2003-2007. Data linkage identified all institutions performing CRC surgery. Multiple hospital level structures were measured. For the final year of our study, the impact of these structures on 30-day mortality was evaluated. Results: 20,784 patients underwent CRC surgery. Each year, between 106 and 109 institutions performed at least one CRC operation. There was variation in hospital level structures of care. After adjustment for patient characteristics, no hospital level structures were independently associated with 30d mortality. Conclusions: Although variation in surgical care and patient outcomes is likely related to variation in processes and structures of care, after adjusting for covariates, our study did not show any significant relationship between hospital level structures and 30-day mortality.
Comparison of Knee Muscle Strength and Endurance of Affected Legs of Korean Women Diagnosed with Kellgren-Lawrence grade (K-L II) by Age

PURPOSE: The purpose of this study was to compare the maximum knee strength and endurance of elderly Korean women with Kellgren-Lawrence grade (K-L II) by age. METHODS: In this study, the total number of participants was 50, divided into five groups of 10 by age. Maximum knee muscle strength was measured at a low speed of 60°/sec using Biodex, an isokinetic device for comparison of maximum knee muscle strength, whereas muscle endurance was measured by muscle contraction at a high speed of 180°/sec. The peak torque values of the extensor and flexor muscles in the muscle strength and muscle endurance tests were collected according to each classification. RESULTS: The results of the experiment show that maximum muscle strength and muscle endurance decreased significantly at 60°/sec and 180°/sec during flexion and extension according to age (p<.05). In particular, the age
Relations entre modes de gestion des agroécosystèmes et biodiversité fonctionnelle des sols

Notre contexte economique, environnemental et societal actuel nous incite a considerer, dans le cadre de la transition agroecologique, des pratiques agricoles limitant l’usage d’intrants de synthese et favorisant la biodiversite planifiee dans les agroecosystemes. Ces pratiques mobilisent certains services ecosystemiques realises par la biocenose du sol. Dans cette communication, nous presentons les principales composantes de la biocenose du sol et certains services ecosystemiques associes. Nous abordons ensuite les impacts des principales pratiques culturales (labour, fertilisation) et des modes de gestion des terres alternatifs. Nous concluons sur l’importance de la preservation de la biodiversite des sols sur la fertilite des agroecosystemes, et suggerons des pratiques cles d’amelioration telles que l’augmentation de la diversite vegetale dans les systemes de culture.
Die Bedeutung des intestinalen Mikrobioms beim ischämischen Schlaganfall

Zusammenfassung Experimentelle und klinische Studien der letzten Jahre belegen die wichtige Rolle der intestinalen Mikrobiota für die Homöostase des Zentralnervensystems (ZNS), aber auch für die Pathophysiologie von ZNS-Erkrankungen. Dabei spielt u. a. der modifizierende Einfluss der Mikrobiota auf die periphere Immunantwort eine wichtige Rolle, die wiederum einen modulierenden Effekt auf die Neuroinflammation im ZNS haben kann. Hier fassen wir die verfügbaren experimentellen und klinischen Daten zur Bedeutung des Mikrobioms beim Schlaganfall zusammen: 1) Schlaganfall verändert die intestinale Mikrobiota; 2) Mikrobiota kann die Prognose nach Schlaganfall beeinflussen; 3) Mikrobiota spielt eine wichtige Rolle in der Pathogenese von (Risikofaktoren) des Schlaganfalls. Aufgrund der vorliegenden klinischen und experimentellen Ergebnisse stehen für die nächsten Jahre klinisch relevante Entdeckungen zur Bedeutung der Darm-Mikrobiota beim Schlaganfall an.
AAV ablates neurogenesis in the adult murine hippocampus

Recombinant adeno-associated virus (rAAV) has been widely used as a viral vector across mammalian biology and has been shown to be safe and effective in human gene therapy. We demonstrate that neural progenitor cells (NPCs) and immature dentate granule cells (DGCs) within the adult murine hippocampus are particularly sensitive to rAAV-induced cell death. Cell loss is dose dependent and nearly complete at experimentally relevant viral titers. rAAV-induced cell death is rapid and persistent, with loss of BrdU-labeled cells within 18 hours post-injection and no evidence of recovery of adult neurogenesis at 3 months post-injection. The remaining mature DGCs appear hyperactive 4 weeks post-injection based on immediate early gene expression, consistent with previous studies investigating the effects of attenuating adult neurogenesis. In vitro application of AAV or electroporation of AAV2 inverted terminal repeats (ITRs) is sufficient to induce cell death. Efficient transduction of the dentate gyrus (DG)—without ablating adult neurogenesis—can be achieved by injection of rAAV2-retro serotyped virus into CA3. rAAV2-retro results in efficient retrograde labeling of mature DGCs and permits in vivo 2-photon calcium imaging of dentate activity while leaving adult neurogenesis intact. These findings expand on recent reports implicating rAAV-linked toxicity in stem cells and other cell types and suggest that future work using rAAV as an experimental tool in the DG and as a gene therapy for diseases of the central nervous system (CNS) should be carefully evaluated.
Customized Graph Embedding: Tailoring Embedding Vectors to different Applications

Graph is a natural representation of data for a variety of real-word applications, such as knowledge graph mining, social network analysis and biological network comparison. For these applications, graph embedding is crucial as it provides vector representations of the graph. One limitation of existing graph embedding methods is that their embedding optimization procedures are disconnected from the target application. In this paper, we propose a novel approach, namely Customized Graph Embedding (CGE) to tackle this problem. The CGE algorithm learns customized vector representations of graph nodes by differentiating the importance of distinct graph paths automatically for a specific application. Extensive experiments were carried out on a diverse set of node classification datasets, which demonstrate strong performances of CGE and provide deep insights into the model.
Optimizing Mental Health in an Academic NurseManaged Clinic

Conclusions This health status evaluation indicated that the mental health scores for clinic clients were lower than national normed data. This result could reflect unmet mental health needs in clinic clients. Mental health reasons for the visit were reported in only 3% of the sample. Most clients in this sample sought treatment in the clinic for physical health screening and episodic health problems.
Host cholesterol dependent activation of VapC12 toxin enriches persister population during Mycobacterium tuberculosis infection

A worldwide increase in the frequency of multidrug-resistant and extensively drug-resistant cases of tuberculosis is mainly due to therapeutic noncompliance associated with a lengthy treatment regimen. Depending on the drug susceptibility profile, the treatment duration can extend from 6 months to 2 years. This protracted regimen is attributed to a supposedly non-replicating and metabolically inert subset of the Mycobacterium tuberculosis (Mtb) population, called ‘persisters’. The mechanism underlying stochastic generation and enrichment of persisters is not fully known. We have previously reported that the utilization of host cholesterol is essential for mycobacterial persistence. In this study, we have demonstrated that cholesterol-induced activation of a ribonuclease toxin (VapC12) inhibits translation by targeting proT tRNA in Mtb. This results in cholesterol-specific growth modulation that increases the frequency of the generation of persisters in a heterogeneous Mtb population. Also, a null mutant strain of this toxin (ΔvapC12) failed to persist and demonstrated an enhanced growth phenotype in a guinea pig model of Mtb infection. Thus, we have identified a novel strategy through which cholesterol-specific activation of a toxin–antitoxin (TA) module in Mtb enhances persister formation during infection. In addition to identifying the mechanism, the study provides opportunity for targeting persisters, a new paradigm facilitating tuberculosis drug development.
Challenges in clinical performance of dentistry clinicians: towards strengthening areas of outcomes or competencies

The study investigated the phenomenon of challenges and difficulties in the clinicalperformance of students in a university, accounting for the frequency of weaknesses and errorsof clinician students during clinical training as observed by the faculty in terms of theirknowledge, practical skills and attitudes. All eighteen faculty clinical consultants who weresupervising the 7 Clinical Departments in the College of Dentistry in a university were invitedto participate in the study, wherein questionnaires were given in two stages to identify andrecall the frequency of occurrence of errors or weaknesses in the clinical performance ofstudent clinicians in the 3rd and 4th year proper levels of the Dentistry Program. The sevenClinical Departments included the Restorative Dentistry Department, Oral DiagnosisDepartment, Periodontics Department, Oral Surgery Department, Endodontics Department,Prosthodontics Department, and the Pediatric Dentistry Department. The findings revealedseveral errors or weaknesses in clinical performance of students and some of these weaknesseswere seen by the clinical consultants to be frequently performed. Some of these are critical inthe proper training of future dentists and thus interventions in the target outcomes in the clinicaltraining program, as well as target outcomes and competencies in the area of pre-clinicaltraining, were recommended to be addressed.
Adherence to insulin treatment in children with type I diabetes mellitus at a hospital in Malaysia

Objective: This study aimed to evaluate adherence to insulin treatment and identify factors that influence adherence in children with T1DM at a tertiary care hospital in Malaysia.Methods: Patients were identified from the pharmacy computer system based on the prescribed insulin therapy from 2010 to 2014. Medical records of screened patients were then retrieved from the medical record department. Adherence was assessed via the medication possession ratio (MPR) and glycated hemoglobin A1c value. Patients were classified as adherent or non-adherent if the MPR calculated for the prescribed insulin regimen was â‰¥80% or 0.05). These predictors were also found to be insignificant based on multiple logistic regression analysis (p>0.05). Conclusion: Adherence to insulin treatment based on the A1c measurement was generally poor among children with T1DM. Further prospective research should be performed in this area to identify reasons for the non-adherence to insulin treatment so that appropriate interventions can be instituted to improve adherence and ultimately prevent complications from the disease. Â
Transethosome: Novel Vesicular Carrier for Enhanced Transdermal Drug Delivery System

Transethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and the systemic circulation. Although transethosome systems are conceptually sophisticated, they are simple in their preparation, safe for use a combination that can highly expand their application. Transethosome are gaining popularity in designing drug delivery systems for topical and transdermal use for their capability to reach deep skin layers and systemic circulation. The dermal route has been recognized as one of the highly potential routes of systemic drug delivery and provide the advantage of avoidance of the first pass effect, ease of use and withdrawal (in case of side effects) and better patient compliance. Transethosome have both ethanol and penetration enhancer due to which drug penetrates through stratum corneum by increase fluidity of cell membrane lipids. The present review includesthe composition, mechanism of penetration, advantage, method of preparation and characterization of transethosome.
Chronic obstructive pulmonary disease, inflammation, and lung cancer

Both lung cancer and chronic obstructive pulmonary disease (COPD) are associated with cigarette smoking, which, by generating reactive oxidant species, induces a chronic inflammatory state in the lung. Activation, particularly of nuclear factor-κB, occurs in both cancer and COPD, and expression of a number of genes is altered in both diseases. In lung cancer, DNA damage, lack of DNA repair, and genomic instability predominate, whereas matrix degradation, lack of repair, and an intense immune response predominate in COPD. The reasons for the different responses to a common inflammatory response induced by smoking remain to be determined, but likely lie in genetic polymorphisms in genes that regulate genome integrity in cancer and that regulate the immune response to tissue destruction in COPD.
Facing the Artificial: Understanding Affinity, Trustworthiness, and Preference for More Realistic Digital Humans

In recent years, companies have been developing more realistic looking human faces for digital, virtual agents controlled by artificial intelligence (AI). But how do users feel about interacting with such virtual agents? We used a controlled lab experiment to examine users’ perceived trustworthiness, affinity, and preference towards a real human travel agent appearing via video (i.e., Skype) as well as in the form of a very human-realistic avatar; half of the participants were (deceptively) told the avatar was a virtual agent controlled by AI while the other half were told the avatar was controlled by the same human travel agent. Results show that participants rated the video human agent more trustworthy, had more affinity for him, and preferred him to both avatar versions. Users who believed the avatar was a virtual agent controlled by AI reported the same level of affinity, trustworthiness, and preferences towards the agent as those who believed it was controlled by a human. Thus, use of a realistic digital avatar lowered affinity, trustworthiness, and preferences, but how the avatar was controlled (by human or machine) had no effect. The conclusion is that improved visual fidelity alone makes a significant positive difference and that users are not averse to advanced AI simulating human presence, some may even be anticipating such an advanced technology.