Miracle-dz/UniFAR-FTUs huggingface dataset:
Toughening Effect of Rodlike Cellulose Nanocrystals in Epoxy Adhesive

Epoxy structural adhesives have been used extensively in the automotive and aerospace industries to bond assembly parts. Much effort has been devoted to enhancing the mechanical properties of epoxy resin by incorporating fillers. Among a variety of fillers investigated for this purpose, nanocelluloses are regarded as a promising type of emerging green filler material because of their excellent mechanical and physicochemical properties. Indeed, nanocelluloses have been used as a filler for polymer nanocomposites. However, the toughening and reinforcing effects of nanocelluloses on rigid epoxy adhesives have not yet been fully revealed, particularly from the perspective of adhesive bonded joints. Here we report that epoxy adhesive containing cellulose nanocrystal (CNC) aggregates produced using a solvent-free ball milling method achieves drastically improved adhesive strength and fracture toughness compared with that of the reference adhesive without CNCs. The epoxy adhesive containing CNC aggregates exhibi.
Accelerating the Emergence of order in Swarming Systems

Our ability to understand and control the emergence of order in swarming systems is a fundamental challenge in contemporary science. The standard Vicsek model (SVM) — a minimal model for swarming systems of self-propelled particles — describes a large population of agents reaching global alignment without the need of central control. Yet, the emergence of order in this model takes time and is not robust to noise. In many real-world scenarios, we need a decentralized protocol to guide a swarming system (e.g., unmanned vehicles or nanorobots) to reach an ordered state in a prompt and noise-robust manner. Here, we find that introducing a simple adaptive rule based on the heading differences of neighboring particles in the Vicsek model can effectively speed up their global alignment, mitigate the disturbance of noise to alignment, and maintain a robust alignment under predation. This simple adaptive model of swarming systems could offer new insights in understanding the prompt and flexible formation of animals and help us design better protocols to achieve fast and robust alignment for multi-agent systems.
A New Supplement for the Treatment of Metabolic Syndrome in Postmenopausal Women

Background: Metabolic Syndrome (MS) is considered a cluster of metabolic abnormalities whose pathogenesis is principally attributable to insulin resistance. Lack of estrogens occurs in postmenopausal women and worsening insulin resistance and lipid profile, predispose to MS. The aim of the study was to show whether a new supplement containing cinnamon, corosolic acid and glycyrrhizic acid may counteract MS manifestations. Methods: A total of 60 postmenopausal women were enrolled in a randomized, controlled trial; the active treatment group was taking the new supplement for 3 months and was on a hypocaloric diet, control group was only on diet. At the beginning and after 3 months, metabolic variables were evaluated. Results: After 3 months, a significant difference in the treated group was observed for glucose, HOMA, total cholesterol and HDL-cholesterol; whereas, in the control group, a significant difference was shown only for glucose. After 3 months, a significant difference between groups was highlighted only for HDL-cholesterol. Conclusion: This study has shown the naturally occurring components of this new supplement may improve insulin resistance and lipid profile in a small sample of postmenopausal women.
Readily-Available Antibiotic Formulations to Improve Outcomes in Cancer Patients with Severe Sepsis and Septic Shock

Readily-Available Antibiotic Formulations to Improve Outcomes in Cancer Patients with Severe Sepsis and Septic Shock Jason D. Goldman, MD Chair of the Supervisory Committee: Corey Casper, MD, MPH Professor, Department of Medicine Adjunct Professor, Departments of Epidemiology and Global Health Background: Cancer patients are at high risk for severe sepsis (SS) and septic shock (SSh) and delay to effective antimicrobial therapy (ABx) is strongly associated with increased mortality. Anti-pseudomonal beta-lactam intravenous monotherapy is equally effective and less toxic than combination therapy for uncomplicated neutropenic fever, but combination therapy may be superior for more severe disease. Methods: We implemented a clinical algorithm to simplify timely and effective empiric ABx and other resuscitative care to cancer outpatients with SS/SSh prior to hospital admission. Triple therapy with meropenem, tobramycin and linezolid or alternatives such as aztreonam for penicillin-allergic patients can be co-administered and provides broad coverage for resistant organisms typically encountered in this population. A pre-printed order form triggered dispensing of kits containing ABx, fluids and dexamethasone. We performed a retrospective cohort study to assess the impact of this strategy. Results: From 1/1/08 through 1/31/12, 162 patients met inclusion criteria. Median age was 53 (IQR: 42 – 63) years and 65% were male. The majority of patients (87%) had hematopoietic malignancies. 77 (48%) were hematopoietic stem cell transplant recipients and 80 (49%) were neutropenic. SSh was diagnosed in 25 patients (15%), SS in 46 (28%), sepsis in 72 (44%) alternative diagnosis in 6 (4%) and infection without systemic inflammatory response syndrome in 13 (8%). Median time from clinical encounter to ABx administration was 111 (IQR: 60 – 178) minutes, 93% had blood cultures drawn prior to ABx, 46% received dexamethasone and 99% had crystalloid infusion started before hospital transfer. De-escalation on hospital day 1 occurred in 95% of persons admitted. 44% of 25 persons with SSh received vasopressors. 71 persons (44%) had bacteremia and 18% of 93 isolates were multidrug resistant. Possible nephrotoxicity occurred in 4 patients. 30 day mortality was 6/160 (4%) including 3/71 (4%) with SS/SSh. For each hour delay to administer antibiotics, there was an18% increased risk of developing SSh or death within 30 days (95% CI: 4 – 34%), p=0.01. Conclusions: A program to simplify choice of aggressive empiric ABx among cancer patients presenting to an ambulatory clinic with suspected sepsis was associated with excellent survival in those with SS/SSh, without excessive adverse events or inappropriately long empiric ABx
Open subset inclusion graph of a topological space

Abstract In this paper we introduce a graph topological structure, called open subset inclusion graph of a topological space on a finite set X, where the vertex set is the collection of nonempty proper open subsets of a topological space and two vertices U 1, U 2 are adjacent or U 1 ∼ U 2 or (U 1, U 2) ∈E, if either U 1 ⊂ U 2 or U 2 ⊂ U 1. The diameter, girth,connectivity, maximal independent sets, different variants of domination number, clique number and chromatic number, degree of , edge and vertex connectivity of are studied
Role of Ultrasonography in Cancer Theranostic Applications

Ultrasound imaging technique involves the use of sound waves and their echoes to produce a picture of internal organs or masses. An ultrasound transducer emits sound waves and picks up the echoes as they bounce off from the body tissue interfaces. These echoes are converted into images to display on the monitor. This imaging modality is completely non-invasive, helps in real time monitoring, it is a cost-effective, portable and versatile instrument with a wide range of clinical utility including characterizing lesions in the liver, urogenital tract, various soft tissues etc. With the introduction of micro-bubbles intravascular structures are examined based on their vascularity. In the context of cancer imaging, ultrasound is used for numerous routine screening examinations; it assists x-ray mammography, it has the ability to characterize liver lesions, with respect to urogenital tract, it helps to detect non-symptomatic cancer in prostate, uterus, ovaries, bladder and kidney. Apart from these, it helps to characterize lymph nodes by its architectural changes and shape, also helps to diagnose and staging of thyroid and neck cancers. This review gives an overview of the history and the current scenario of targeted ultrasound imaging of cancers of different tissues.
All‐Printed MnHCF‐MnOx‐Based High‐Performance Flexible Supercapacitors

Here, a simple active materials synthesis method is presented that boosts electrode performance and utilizes a facile screen‐printing technique to prepare scalable patterned flexible supercapacitors based on manganese hexacyanoferrate‐manganese oxide and electrochemically reduced graphene oxide electrode materials (MnHCF‐MnOx/ErGO). A very simple in situ self‐reaction method is developed to introduce MnOx pseudocapacitor material into the MnHCF system by using NH4F. This MnHCF‐MnOx electrode materials can deliver excellent capacitance of 467 F g−1 at a current density of 1 A g−1, which is a 2.4 times capacitance increase compared to MnHCF. In addition a printed, patterned, flexible MnHCF‐MnOx/ErGO supercapacitor is fabricated, showing a remarkable areal capacitance of 16.8 mF cm−2 and considerable energy and power density of 0.5 mWh cm−2 and 0.0023 mW cm−2, respectively. Furthermore, the printed patterned flexible supercapacitors also exhibit exceptional flexibility, and the capacitance remains stable, even while bending to various angles (60°, 90°, and 180°) and for 100 cycles. The flexible supercapacitor arrays integrated by multiple prepared single supercapacitors can power various LEDs even in the bent states. This approach offers promising opportunities for the development of printable energy storage materials and devices with high energy density, large scalability, and excellent flexibility.
Design of multi-stage charging power supply for TETS lithium battery based on PNGV model

In this paper, a multi-stage TETS charging system of the PNGV model of lithium-ion battery is proposed based on on the analysis of the equivalent circuit model of lithium-ion battery and the existing charging method. Using this system, the charging speed is increasing while the polarization and the temperature rising is suppressed. Taking into account the charging quality of the the lithium-ion battery, the actual charging curve is closer to the optimal charging curve in this system. Combining MATLAB and SIMPLORERMAXWELL multi-platform, the effectiveness of the scheme is verified by joint simulation. The simulation results have theoretical research and practical application value for the establishment of TETS charging system platform for lithium-ion battery.
Construction and commissioning of the tracker for the SuperNEMO Demonstrator Module and Unfolding the 2νββ spectrum of 100Mo from the NEMO-3 experiment

The SuperNEMO experiment will search for the neutrinoless double beta decay of 82Se, with an expected half-life sensitivity of >10^26 years. The first stage of the experiment, the SuperNEMO Demonstrator Module, is expected to achieve a half-life sensitivity of 6.6×10^24 years after running for 2.5 years with 7 kg of source isotope. Key results from the construction, and commissioning of the wire tracker for the Demonstrator Module are described, and the drift distance-time relationship of each of the first three quarters measured. The two-neutrino double-beta decay half-life of 100Mo has been measured as 7.01±0.01(stat)±0.46\(syst)×10^18 years using a sample of 6914 g of isotope measured for 5.25 years by the precursor experiment, NEMO-3. The summed electron energy spectrum was unfolded, allowing for a limit of -1.12×10^-1 < a³_of < 6.95×10^-2 MeV to be placed on the Lorentz Violating operator a³_of. A further unfolded distribution in the three dimensions of summed energy, energy asymmetry, and the opening angle of the emitted electrons has been produced, allowing subsequent experiment-agnostic analyses.
Una revisión comparativa de la literatura acerca de metodologías tradicionales y modernas de desarrollo de software

Existen una gran variedad de metodologías de desarrollo de software, con diferencias significativas en cuanto al tipo de proceso empleado y productos obtenidos, cantidad de recursos involucrados, tiempos de desarrollo y estructura organizacional requerida. Considerando la diversidad de información disponible, este trabajo presenta una revisión enfocada a identificar las tendencias reportadas en la literatura sobre metodologías de desarrollo de software, incluyendo tanto las modernas como las tradicionales. Se aplicaron filtros de búsqueda para seleccionar estudios primarios y secundarios, encontrando que las metodologías de desarrollo tradicionales más reportadas son los de tipo cascada y modelos en espiral, mientras que entre las metodologías modernas las ágiles son las más reportadas, incluyendo programación extrema, scrum, desarrollo orientado a funcionalidades y las basadas en componentes. Se identificaron y compararon las principales ventajas y desventajas de las metodologías, buscando que este trabajo sirva como un punto de partida para los desarrolladores de software a nivel empresarial, educativo e investigativo.
Essai de modélisation des échanges et des réseaux de circulation dans les Alpes centrales au premier âge du Fer

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Essai de modelisation des echanges et des reseaux de circulation dans les Alpes centrales au premier âge du Fer Veronica Cicolani, Thomas Huet
Glucocortycosteroids and disturbances of glucose metabolism

Glikokortykosteroidy (GS) nalezą do grupy hormonow steroidowych, ktore u ludzi regulują szerokie spektrum reakcji fizjologicznych niezbednych do zycia, takich jak wzrost, reprodukcja, reakcje immunologiczne i zapalne. Syntetyczne GS są powszechnie stosowanymi lekami w chorobach zapalnych, autoimmunologicznych i limfoproliferacyjnych. Steroidoterapia wiąze sie jednak z wystepowaniem wielu dzialan niepoządanych, w tym zaburzen metabolicznych. Jednym z nich jest cukrzyca posteroidowa. Za efekt diabetogenny GS odpowiada kilka mechanizmow, takich jak antago­nistyczne dzialanie w stosunku do insuliny, wzrost insulinooporności na poziomie wątroby, mieśni szkieletowych i tkanki tluszczowej, upośledzenie zdolności sekrecyjnych komorki beta, wplyw na komorki alfa i wzrost wydzielania glukagonu, zmniejszenie efektu inkretynowego czy stymulowanie gromadzenia sie tluszczu trzewnego. Zaburzenia gospodarki weglowodanowej wywolane dzialaniem GS charakteryzują sie prawidlowym lub nieznacznie podwyzszonym stezeniem glukozy na czczo i istotnym wzrostem glikemii poposilkowych, zwlaszcza w godzinach popoludniowych i wieczornych. Wysilki terapeutyczne powinny zatem byc ukierunkowane na zwalczanie tych wlaśnie zaburzen.
Factores edáficos y nemátodos entomopatógenos en un agroecosistema neotropical de banano

Edaphic factors and entomopathogenic nematodes in a neotropical banana agroecosystem. Introduction: In Costa Rica the banana is one of the most important crops in terms of production and exports; the application of pesticides is hence necessary to control the effect of pests on the plantation, such as the Cosmopolites sordidus black weevil. Because of the harmful effects of pesticides on human and environmental health, and the possibility that pests become resistant to these substances, alternatives compatible with the environment, as potential biological controllers, have been investigated to complement the effect of agrochemicals. The entomopathogenic nematodes (EPN) of genera Heterorhabditis and Steinernema have become a focus of study in the field of biological control because of their symbiotic relation with bacteria of genera Photorhabdus and Xenorhabdus, which are a complex capable of eliminating host insects in hours. Objective: The objective was to determine the presence of EPN of genera Heterorhabditis and Steinernema in soil samples taken from banana plantations in the Caribbean region of Costa Rica, and to characterize their habitat. Methods: Sampling points were selected within the plantations and surrounding areas; physicochemical and microbiological analyses were undertaken (pH, acidity, organic matter, Ca, K, Mg, P, Fe, Cu, Zn, Mn, texture, biomass and microbial respiration of the soil, EPN isolation). Variables were analyzed statistically to determine differences between them, in sampling sites, and samples with presence and absence of EPN. A principal-component analysis (PCA) was undertaken using the variables of greater influence in both categories to find their combinations that would explain their presence according to habitat conditions. A discriminant analysis was undertaken to determine the efficiency of the variables selected in the diagnosis of nematode occurrence. Results: The variables related to the presence of EPN were shown to correspond to organic matter, carbon biomass and microbial respiration. Of the samples 38.4 % were found to be positive with respect to the presence of EPN, of which 95 % correspond to genus Steinernema and the remaining 5 % to Heterorhabditis. According to the quadratic discriminant equation, from 81.2 % of the samples without nematodes, six belong to the group with their presence, whereas for those with EPN, 55.0 % (nine of 20) belong to the absence group. Conclusions: No statistical difference was found between the selected sampling habitats (P = 0.4296); the three variables mentioned above were thus determined have an influence on the presence of EPN; their large values indicate favorable conditions for their persistence.
Preparation and evaluation of burns wound healing ointment base of leaves and stem bark of Anthocleista djalonensis (L) extract using animal model.

BACKGROUND: Burn wounds are inescapable life events especially in low income areas. Contamination of the burn wound site results in localized wound infection, hence the need for potent phytochemicals readily available for wound healing. The use of stem bark of Anthocleista djalonensis efficacy for burn wound has not been evaluated to the best of our knowledge. AIM: The study is aimed at evaluating and comparing the wound healing potential of ointment base of leaves and Stem bark of Anthocleista djalonensis on burn wounds created on wistar albino rats. METHODS: The leaves and Stem bark of Anthocleista djalonensis collected were extracted using 95%v/v methanol and phytochemical analysis conducted. Simple ointments of varying concentrations were formulated to screen for wound healing activity using the burn wound model on experimental rats grouped into six (n=4). Group 1 was treated with silver sulfadiazine cream (positive control), group 2 with ointment base (negative control), group 3 with 1% stem bark extract ointment, group 4 with 2% stem bark ointment, group 5 with 1% leave extract ointment, and group 6 with 2% leave extract ointment. All animals were anesthetized before the creation of burn wounds. Measurement was taken on day zero and the wound was left untreated for 48 hours in order to allow bacterial colonization before daily treatment of the wound for 16 days. RESULTS: The result of the phytochemical screening revealed that both extract of Anthocleista djalonensis contains flavonoids, tannins and saponins. On day 2, 1% stem bark, 2% stem bark and 1% leaf extract had 16%, 15%, and 10% wound contraction respectively which was higher than the 8.5% wound contraction of silver sulfadiazine. Also as the concentration of the extract increased, the wound healing effect also increased as seen by the percentage wound contraction on day 16 for all treatment. CONCLUSION: The findings of the study have shown that methanolic extracts of stem bark and leaf of Anthocleista djalonensis contained bioactive constituents which have burn wound healing activity. The stem bark extract showed better activity when compared with the leaf extract and also the positive control (silver sulfadiazine).
Akalazya: Cerrahi olarak tedavi edilen 6 olgunun irdelenmesi

Giris ve amac: Akalazya, etiyolojisi bilinmeyen, ozofagusun primer motilite bozuklugudur. Bu calismada klinigimizde akalazya tanisi konulan olgularin tedavi algoritmi retrospektif olarak irdelenmistir. Gerec ve yontem: Eylul 1996- Kasim 2002 tarihleri arasinda , klinigimizde akalazya tanisi konulan ve tedavi edilen 6 olgu, yas, cinsiyet, semptom, ust gastrointestinal endoskopi ve ozofagus,mide , duodenum pasaj grafileri, manometrik olcumleri, uygulanan endoskopik ve cerrahi tedavi yontemleri ve izlem sonuclari acisindan degerlendirildi. Bulgular: Olgularin tumu erkek olup yas ortalamasi 47,9(31-69) idi. Yutma guclugu tum olgularda primer semptom olup, 5 olguda retrosternal yanma ve 3 olguda da regurjitasyon mevcuttu. Olgularin tumunde pasaj grafileri akalazyayla uyumlu olup, 5 olguda da endoskopi ile tani konuldu. Dort olguya pnomotik dilatasyon uygulanmis olup, tedavi sonrasi semptomlarin tekrar etmesi uzerine cerrahi uygulandi.Iki olguda ise cerrahi primer tedavi olarak yapildi.Olgularda mortaliteye rastlanilmadi. Sonuc:Akalazyanin tedavisinde ; endoskopik pnomotik dilatasyon ilk tercih edilen tedavi yontemi olup, 40 yas altinda, ek cerrahi hastaligi olan ve pnomotik dilatasyon sonrasi semptomlari tekrarlayan olgularda cerrahi yapilmalidir.
In vitro and in silico Evaluation of Some Natural Molecules as Potent Glutathione Reductase Inhibitors

Glutathione reductase inhibitors are very popular antimalarial and anticancer agents. In this study, in vitro inhibition effects of β -sitosterol, stigmasterol, diosgenin and jervine which containing steroidal structure were determined against glutathione reductase enzyme. β- sitosterol, diosgenin and jervine were isolated from Veratrum album and stigmasterol was isolated from Artemisia dracunculus L. by chromatographic methods. According to the results obtained, IC 50 values of β -sitosterol, stigmasterol, diosgenin and jervine were found as 1.2580, 5.2116, 0.1916 and 0.7701 µM, respectively. Among test compounds, diosgenin showed the strongest inhibitory effect against glutathione reductase with Swissdock docking figure. In current study first time, β -sitosterol, stigmasterol, diosgenin and jervine were found to be much more glutathione reductase inhibitors.