Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapeutic Roles of Goji Berry and Ginseng in Traditional Chinese

Background: Goji berries (Lycium barbarum), widely used in traditional Chinese medicine, can be applied as a dietary supplement. They are classified as nutraceutical food due to their long and safe traditional use. Ginseng has been increasingly used in the last decades and has become well known for its significant role in preventing and treating many diseases. Methods: The keywords of Goji berry, Ginseng, Traditional Chinese medicine were searched in Google Scholar, Scopus, Research Gate, and PubMed in both English and Chinese languages. Results: Goji berry significantly inhibited the generation and spread of cancer cells, improved eyesight, and increased reserves of muscle glycogen and liver glycogen, which may increase human energy and has anti-fatigue effect. Usage of Goji berries improved brain function and enhanced learning and memory. It had positive effects on anti-cancer, anti-oxidant activities, retinal function preservation, anti-diabetes, immune function, and anti-fatigue. Pharmacological activities of ginseng extracts affected the central nervous system, antipsychotic action, tranquilizing effects, protection from stress ulcers, increase of gastrointestinal motility, anti-fatigue action, endocrinological effects, enhancement of sexual behavior, acceleration of metabolism, or synthesis of carbohydrates, lipids, RNA, and proteins. In Traditional Chinese Medicine, ginseng helps to maintain a healthy immune system. Conclusions: In this review article we found that Goji berries and Ginseng were sources of compounds with valuable nutritional and bioactive properties. Therefore, they could be incorporated into foods with functional properties. More clinical studies are necessary to uncover the numerous substances and their effects in goji berries and ginseng that contribute to public health.
Studying POU2F1 to Unveil the Structural Facet for Pan-Cancer Analysis Considering the Functional Annotations and Sequence-Structure Space Paradigm

POU domain class 2 homebox 1 (POU2F1) is largely known for its transcription factor(TF) activity. Due to its association with different types of malignancies, POU2F1 becomes one of the key factors in pan-cancer analysis. However, in spite of understanding it as a potential drug target, none of the drug has been designed till date due to its extreme dynamicity. In this article, we have proposed a three fold comprehensive framework for understanding the structural conservation and co-variation of POU2F1. Firstly, a gene regulatory network based non-pathogenic and pathogenic study have been performed to understand the strong association between cancers and POU2F1. After that, based on evolutionary sequence space study, the comparative sequential dynamicity of the protein members of POU domain family has been observed mostly between non-human and human samples. Subsequently, the reciprocity effect of the residual co-variation has been identified through direct coupling analysis. Along with that, the structure of POU2F1 has been analysed depending on quality assessment and normal mode based structure network. Comparing the sequence and structure space information, the most significant set of residue viz., 3, 9, 13, 17, 20, 21, 28, 35, 36 have been identified as structural facet for stable binding. It is observed that targeting these residues can help to prevent the monomeric aggregations. This study demonstrates-the observed malleability of POU2F1 is one of the prime reason behind its functional multiplicity in terms of protein moonlighting. SIGNIFICANCE POU2F1 is one of the important TFs associated with several malignancies. In spite of orderly stable structure in primitive family proteins, this protein is highly unstable at the monomeric stage. Previous studies show that POU2F1 has a clear association with 121 different diseases. Therefore, it becomes one of the important links in the pan-cancer study. Interestingly, TFs can be considered as a potential drug target. However, it is hardly possible to control the extreme dynamicity of TFs. In this regard, protein moonlighting plays an important role. We have tried to provide a theoretical frame to build understanding on POU2F1. The study provides pathogenic and non-pathogenic connections of the protein in terms of comprehensive and precise Gene Regulatory Network. Subsequently, the instability has been unveiled and the structural facet has been identified. Finally, the specified set of function for a suitable session to target the protein is analyzed based on protein moonlighting properties.
Abordagem perioperatória do doente diabético Perioperative management of diabetic patient

The hyperglycemia is a common finding in hospitalized patients, with or without previous diagnosis of diabetes. It has been recently considered as an independent marker of bad prognosis and of raised mortality. The aggressive control of the glycaemia levels has been recognized in several reference studies as an important therapy target for the treatment of serious acute illness. It can also be related to the improvement of the clinical results and a significant reduction of mortality. Diabetic patients are prone to a more frequent and longer hospitalization and to a larger number of surgical interventions. It is justifiably associated with an increased morbidity and mortality rate. Consequently, it requires a specific therapy strategy, which would improve its prognosis. This paper aims at presenting the diabetic patient’s preparation for the operation, as well as the main insulin treatments in the perioperative period. It discloses the intensive insulin therapy’s prescription according to the protocols previously established, adapted to the patients and institutions reality.
The effect of frost and hale on the peach tree cultivars from R.S.F.G. Constanța.

In this study, few aspects regarding the influence of different storage condition upon the shelf life of some apple cultivars were highlighted. In the experiment following apple cultivars were used: ‘Redix’, ‘Rubinola’ and ‘Golden Delicious’. All fruits were harvested at the harvesting ripeness time. Afterwards, the apple fruits were stored in different environments, which consists the experimental variants: natural ventilation, cooling storage, cooling storage by using micro perforated bag pre-package and cooling storage by using semipermeable plastic bag package introduced into plastic material boxes. The obtained results show that the fruit storage period ranges from 80 days for ‘Golden Delicious’, 95 days for ‘Redix’ and ‘Rubinola’ in natural ventilation conditions to 130 days for ‘Golden Delicious’ and 140 days for ‘Redix’ and ‘Rubinola’, in conditions of refrigerating storage and fruit semipermeable plastic bags package. Regarding the rotting process, the main pathogens involved were Gloeosporium album for ‘Golden Delicious’ and Penicillium sp. for ‘Rubinola’.
Arabidopsis ENHANCED DISEASE RESISTANCE1 Protein Kinase Regulates the Association of ENHANCED DISEASE SUSCEPTIBILITY1 and PHYTOALEXIN DEFICIENT4 to Inhibit Cell Death

ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1) and PHYTOALEXIN DEFICIENT4 (PAD4) are sequence-related lipase-like proteins that function as a complex to regulate defense responses in Arabidopsis by both salicylic acid-dependent and independent pathways. Here we describe a gain-of-function mutation in PAD4 (S135F) that enhances resistance and cell death in response to infection by the powdery mildew pathogen Golovinomyces cichoracearum. The mutant PAD4 protein accumulates to wild-type levels in Arabidopsis cells, thus these phenotypes are unlikely to be due to PAD4 over accumulation. The phenotypes are similar to loss of function mutations in the protein kinase Enhanced Disease Resistance1 (EDR1), and previous work has shown that loss of PAD4 or EDS1 suppresses edr1-mediated phenotypes, placing these proteins downstream of EDR1. Here we show that EDR1 directly associates with EDS1 and PAD4 and inhibits their interaction in yeast and plant cells. We propose a model whereby EDR1 negatively regulates defense responses by interfering with the heteromeric association of EDS1 and PAD4. Our data indicate that the S135F mutation likely alters an EDS1-independent function of PAD4, potentially shedding light on a yet unknown PAD4 signaling function.
A New Vegetative Albino Form of the Otherwise Mixotrophic Orchid Cephalanthera subaphylla (Orchidaceae)

parts (reviewed by Selosse & Roy 2009). The genus Cephalanthera includes both fully and partially mycoheterotrophic species, five species and four forms of which are known to occur in Japan (Hayakawa et al. 2014, 2016). Cephalanthera falcata (Thunb.) Blume f. falcata, f. albescens S. Kobay. , f. conformis Hiros. Hayak. & J. Yokoy. , C. erecta (Thunb.) Blume, C. longibracteata Blume f. longibracteata, f. lurida Hayashi, and C. longifolia (L.) Fritsch have well-developed foliage leaves, while C. subaphylla Miyabe & Kudô f. subaphylla has only extremely reduced leaves and are highly dependent on a mycoheterotrophic mode of nutrition (Yukawa 2015, Hayakawa et al. 2016, Sakamoto et al. 2016). As with some foreign species of Cephalanthera (Selosse & Roy 2009), some Japanese species, such as C. falcata and C. subaphylla, produce achlorophyllous leafbearing variants (hereafter albino; Umezawa 2009, Suetsugu & Kato 2014, Suetsugu 2015a, b). None of the Japanese albino Cephalanthera variants, however, have been given scientific names. Here, I describe a new form of C. subaphylla where the entire plant is achlorophyllous. All 25,000 species of orchids are assumed to be initially mycoheterotrophic, which means they rely on a fungal host for their carbon and mineral nutrient during the early seedling phase (Cameron et al. 2006). Later on, however, most orchids develop green leaves and become autotrophic. Regardless, more than 200 species of orchids remain achlorophyllous throughout their life. Those orchids totally depend upon their fungal host for carbon and most likely for mineral nutrients. This nutritional mode is referred to as full mycoheterotrophic (Leake 1994). While the vast majority of orchids develop photosynthetic leaves and are fully autotrophic in adulthood (Cameron et al. 2006), several orchids have a mixotrophic strategy where they obtain carbon not only through photosynthesis, but also from mycorrhizal fungi (Gebauer & Meyer 2003). Mixotrophy is often considered to be an intermediate state leading to full mycoheterotrophy, which evolves after the establishment of mixotrophy rather than through direct transition from autotrophy to mycoheterotrophy (Selosse & Roy 2009, Motomura et al. 2010). Some mixotrophic orchids produce fully achlorophyllous leaf-bearing variants that can Acta Phytotax. Geobot. 68 (3): 199–201 (2017) doi: 10.18942/apg.201704 ISSN 1346-7565
Evaluation of the Epidemiological Relevance of Variable-Number Tandem-Repeat Genotyping of Mycobacterium bovis and Comparison of the Method with IS6110 Restriction Fragment Length Polymorphism Analysis and Spoligotyping

Sources of Mycobacterium bovis contamination remain unclear for many cases of animal and human disease. A major limitation is the lack of sufﬁciently informative or epidemiologically well evaluated molecular methods for typing. Here, we report an evaluation of a high-throughput method based on 29 mycobacterial interspersed repetitive unit–variable-number tandem-repeat (MIRU-VNTR) loci to genotype 127 M. bovis isolates from cattle from 77 different Belgian farms, representative of a nationwide collection obtained from 1995 to 2003. MIRU-VNTR stability was demonstrated by analyzing a series of 74 isolates in total, obtained from different animals from a single farm or from different farms with an identiﬁed epidemiological link. The genotyping results and the genotypic diversity ( h ) were compared with those obtained by IS 6110 restriction fragment length polymorphism (RFLP) analysis and spoligotyping. Among 68 isolates with no known epidemiological link, MIRU-VNTR typing discriminated better than either RFLP analysis or spoligotyping, with isolates taken individually (32 versus 16 and 17 genotypes; h (cid:1) 0.91 versus 0.73 and 0.85, respectively) or in combination (32 versus 28 genotypes; h (cid:1) 0.91 versus 0.92). Maximal resolution was already achieved with a subset of 9 loci. The observed congruence of the genetic relationships based on IS 6110 RFLP analysis, spoligotyping, and MIRU-VNTR markers is consistent with a clonal population structure of M. bovis. These results support MIRU-VNTR typing as a convenient and discriminatory technique for analysis of the population structure of M. bovis in much greater detail and for addressing some still unresolved issues in the epidemiology of the pathogen.
Cryptic Patterns of Speciation in Cryptic Primates: Microendemic Mouse Lemurs and the Multispecies Coalescent.

Mouse lemurs (Microcebus) are a radiation of morphologically cryptic primates distributed throughout Madagascar for which the number of recognized species has exploded in the past two decades. This taxonomic revision has prompted understandable concern that there has been substantial oversplitting in the mouse lemur clade. Here, we investigate mouse lemur diversity in a region in northeastern Madagascar with high levels of microendemism and predicted habitat loss. We analyzed RADseq data with multispecies coalescent (MSC) species delimitation methods for two pairs of sister lineages that include three named species and an undescribed lineage previously identified to have divergent mtDNA. Marked differences in effective population sizes, levels of gene flow, patterns of isolation-by-distance, and species delimitation results were found among the two pairs of lineages. Whereas all tests support the recognition of the presently undescribed lineage as a separate species, the species-level distinction of two previously described species, M. mittermeieri and M. lehilahytsara is not supported - a result that is particularly striking when using the genealogical discordance index (gdi). Non-sister lineages occur sympatrically in two of the localities sampled for this study, despite an estimated divergence time of less than 1 Ma. This suggests rapid evolution of reproductive isolation in the focal lineages, and in the mouse lemur clade generally. The divergence time estimates reported here are based on the MSC calibrated with pedigree-based mutation rates and are considerably more recent than previously published fossil-calibrated relaxed-clock estimates. We discuss the possible explanations for this discrepancy, noting that there are theoretical justifications for preferring the MSC estimates in this case.
A NOVEL METHOD BASED ON BISECTION SEARCH ALGORITHM FOR EXTRACTING THE REFERENCE PARAMETERS OF PV MODULES

Manufacturers generally share datasheet values of photovoltaic (PV) modules at only standard test conditions (STC). These conditions enable PV modules to generate high power but are rarely encountered in the real environment. Therefore, accurate modeling of PV modules is very important in terms of estimating the energy that can be obtained under all operating conditions. Many studies have been conducted in this field in the literature. In this study, a new method is proposed for the implementation of the commonly used five-parameter model. This new method uses a bisection search algorithm for calculating the value of the series resistance, which is one of the five parameters, and thus extracting the other parameters. The datasheet values provided by the manufacturers are sufficient for obtaining the series resistance and therefore other parameters. The accuracy of the method was first tested by comparing the datasheet values of the three different PV modules with the outputs of the proposed method. Finally, the simulation accuracy of the proposed method for different operating conditions was tested by comparing the real measurement data collected by the National Renewable Energy Laboratory (NREL) with the outputs of the method under the same operating conditions. The results show that the proposed method demonstrates good agreement with both datasheet values and real measurement data. The method offers a good balance of simplicity-accuracy.
Sit Back or Dig In: The Role of Activity Level in Landscape Market Segmentation

Activity level, or the amount of action/interaction with a product, can be an indication of interest in a product category and influences purchases. Our goal was to assess the overall market for landscape plants using consumers’ activity level from the active/passive continuum proposed by Pine and Gilmore (2011). An online survey instrument was administered to invitees from a national online panel from 7 to 13 Sept. 2016 yielding 1543 useful responses. Factor analysis of 23 items adapted from a previous study revealed five factors, including one active factor and a separate passive factor. These two factors were used in the present study as a basis for a k-means cluster analysis. Two clusters emerged and were labeled “Active Engagement” and “Obligatory Passive Engagement” in landscape activities. We compared cluster means for all five factors and found the Active cluster purchased more plants of all types as well as had greater landscape pride and desire for a low (water) input landscape. Members of the Active cluster were from higher income and education households which were slightly larger and more likely to have Caucasian residents compared with the Passive cluster. In practice, retail employees and landscape professionals might initially ask about consumers’ activity level desired in the landscape as a screening question. Subsequent assistance in design and/or plant selection/purchase could then be tailored toward the desired activity level.
Paradoxical Aortic Stiffening and Subsequent Cardiac Dysfunction in Hutchinson-Gilford Progeria Syndrome

Hutchinson-Gilford Progeria Syndrome (HGPS) is an ultra-rare disorder with devastating sequelae resulting in early death, presently believed to stem primarily from heart failure secondary to central arterial stiffening. We analyze novel longitudinal cardiovascular data from a mouse model of HGPS (LmnaG609G/G609G) using allometric scaling and advanced computational modelling and show that a late-stage increase in pulse wave velocity, with associated diastolic dysfunction but preserved systolic function, emerges with a loss of aortic function, independent of sex. Specifically, there is a dramatic late-stage loss of smooth muscle function and cells and an excessive accumulation of proteoglycans along the entire aorta, which result in a loss of biomechanical function (contractility and elastic energy storage) and marked structural stiffening despite a distinctly low intrinsic material stiffness that is consistent with the lack of functional lamin A. Importantly, vascular function appears to be normal within the low stress environment of development, only to succumb progressively to pressure-related effects of the lamin A mutation and become extreme in the peri-morbid period. Because the dramatic life-threatening aortic phenotype manifests during the last quarter of life there may be a therapeutic window in maturity that could alleviate concerns with therapies administered during early periods of arterial development. Disclosures D.T. B is an equity holder in, and receives research and consulting support from, Inozyme Pharma, Inc. for therapeutics for ENPP1 deficiency. None of the other authors declare any conflict, financial or otherwise.
Cell-Surface Proteomic Profiling in the Fly Brain Uncovers Wiring Regulators

Molecular interactions at the cellular interface mediate organized assembly of single cells into tissues, and thus govern the development and physiology of multicellular organisms. Here, we developed a cell-type-specific, spatiotemporally-resolved approach to profile cell-surface proteomes in intact tissues. Quantitative profiling of cell-surface proteomes of Drosophila olfactory projection neurons (PNs) in pupae and adults revealed a global down-regulation of wiring molecules and an up-regulation of synaptic molecules in the transition from developing to mature PNs. A proteome-instructed in vivo screen identified 20 new cell-surface molecules regulating neural circuit assembly, many of which belong to evolutionarily conserved protein families not previously linked to neural development. Genetic analysis further revealed that the lipoprotein receptor LRP1 cell-autonomously controls PN dendrite targeting, contributing to the formation of a precise olfactory map. These findings highlight the power of temporally-resolved in situ cell-surface proteomic profiling in discovering new regulators of brain wiring.
Performance of cows and summer-born calves and economics in semi-confined and confined beef systems

ABSTRACT Objectives Cow and calf performance in a semi-confined cow-calf production system was compared with total confinement using summer-born calves. Material and Methods The experiment was conducted over 3 yr in eastern Nebraska (ENREC) and 2 yr in western Nebraska (PREC) in a randomized complete block design. Lactating, crossbred beef cows (n = 127 at ENREC; n = 56 at PREC) with summer-born calves were used from November to April. Treatments were (1) dry-lot feeding or (2) cornstalk grazing with supplementation. Dry-lot pairs were limit fed a crop residue and distillers–based diet to meet energy requirements of a lactating cow. A dried distillers grain–based pellet was supplemented to pairs on cornstalks at a rate of 2.4 kg of DM/pair daily. Dry-lot cow-calf pairs were limit fed 12.1 kg of DM/d throughout the trial. Results and Discussion At ENREC, cows wintered on cornstalks lost BW and had a 0.46-unit decrease in BCS (P < 0.01), whereas cows in the dry-lot gained BW and had a 0.24-unit increase in BCS. At PREC, BCS increased by 0.03 units for cows wintered in the dry-lot and decreased by 0.26 units for cows wintered on cornstalks (P < 0.04). At both locations, calves fed in a dry-lot had greater ADG and BW per day of age compared with calves offered cornstalk grazing with supplementation (P ≤ 0.03). Implications and Applications A partial budget suggests that lower winter production inputs compensate for reduced performance of calves when cow-calf pairs are wintered on cornstalks, making residue grazing a viable option in partial confinement systems.
Recent Innovations in Soft Computing Applications

The advancements of hybrid and the collection of procedures in the field of soft computing (SC) in biomedical science has turned out to be more fascinating. The importances of these techniques are propelled by their energy of having the capacity to express information contained in informational indexes in various ways by profiting each other. Particularly while managing high-dimensional complex issues. The combination of the essential innovations into hybrid SC techniques encourages solutions for cutting edge and complex issues [1-10].
PREGNANT WOMEN IN OPIOID MAINTENANCE TREATMENT (OMT): MATERNAL AND NEONATAL OUTCOMES

Objectives: Given that buprenorphine+naloxone is prescribed for opioid-dependent pregnant women, it is important to examine the extent to which it differs from buprenorphine alone, methadone, or methadone-assisted withdrawal on neonatal and maternal outcomes. Methods: All data presented are gathered from 7 previously published studies. Not all studies from which data were extracted had data for all outcomes. Results: Differences in maternal and neonatal outcomes from exposure to buprenorphine+naloxone during pregnancy compared to buprenorphine alone, methadone, or methadone-assisted withdrawal were non-existent or small. Conclusions: These preliminary findings suggest no significant adverse maternal or neonatal outcomes related to the use of buprenorphine+naloxone for the treatment of opioid dependence during pregnancy. However, further research should examine possible differences between buprenorphine+naloxone and buprenorphine alone or methadone in fetal physical development. Patient preference, individual risk:benefit ratio, and treatment context should be considered when prescribing any medication during pregnancy.