Miracle-dz/UniFAR-FTUs huggingface dataset:
A Triple Take on Information System Implementation

While researchers have used a variety of models to explain information system (IS) implementation outcomes, few have analyzed the same project or set of projects with different models looking for complementary explanations. Recognizing the multilevel nature of IS implementation, our study rises to this challenge by conducting an alternate template analysis of three cases of IS implementation in hospitals. First, we explain individual use, group resistance, and organizational adoption with models situated at the same level of analysis as each outcome. At the individual level, we use a model of cognitive absorption to explain individual system usage. At the group level, the political variant of interaction theory is used to explain group resistance to IS implementation. At the organizational level, we use organizational configurations to explain IS adoption in terms of emergence and routinization. We identify each model's limits and prediction failures, and we show that using alternate models helps to remedy a model's prediction failures and overcome its limits. Finally, we propose an alternate-template theory of IS implementation outcomes that takes into account all three levels of analysis, their respective outcomes, and the time dimension. This multilevel, longitudinal theory provides a better understanding of IS implementation and further elucidates what may initially have seemed to be contradictory results.
Demonstration of the Sensorized RBO Hand 2 : Using Task Knowledge to Efficiently Sensorize Soft Actuators

Contact with objects and the environment will cause complex deformations in soft hands. While the space of possible deformations of soft hands is very large due to their flexible materials, deformations that actually occur during contact interactions are much more limited. We use this knowledge to add sensors that measure task-relevant deformations. This demo presents the Sensorized RBO Hand 2, capable of measuring three-dimensional deformation of each of its four fingers. This enables it to detect and measure contacts that occur during grasping and manipulation.
Nuclear transplantation in mammals: Remodelling of transplanted nuclei under the influence of maturation promoting factor

Whilst the role of Maturation or M‐phase Promoting Factor (MPF) as a universal M‐phase regulator is well documented, much less attention has been paid to its role in nuclear transplantation experiments and especially to its influence upon remodelling of transplanted nuclei. There is currently wide acceptance that successful nuclear transplantation using differentiated nuclei is possible only in a cytoplasmic environment that is capable of inducing rapid nuclear de‐differentiation to a pronuclear‐like form. In this review our purpose is firstly, to outline the conditions under which such remodelling can be induced, and secondly, to extend the debate to include a consideration of whether complete nuclear remodelling is an absolute necessity for clonal development.
Large Compressive Pseudomeningocele Causing Early Major Neurologic Deficit After Spinal Surgery

Study Design: Retrospective review. Objectives: Large compressive pseudomeningocele causing a major neurologic deficit is a very rare complication that is not well described in the existing literature. Methods: Institutional review board consent was obtained to study 2552 consecutive extradural spinal surgical cases performed by a single senior spinal surgeon during a 10-year period. The surgeon’s database for the decade was retrospectively reviewed and 3 cases involving postoperative major neurologic deficits caused by large compressive pseudomeningocele were identified. Results: The incidence of postoperative compressive pseudomeningocele causing major neurologic deficit was 0.12% (3/2552) per decade of spinal surgery with approximately 1.3% of cases incurring incidental durotomy. Average age of the patients was 57 years (range 45-78). One patient had posterior cervical spine surgery, and 2 patients had posterior lumbar surgery. All 3 patients had intraoperative incidental durotomy repaired during their index procedure. Large compressive pseudomeningocele causing major neurologic deficit occurred in the early 2-week postoperative period in all patients and was clearly identified on postoperative magnetic resonance imaging. All 3 patients were treated with emergent decompression and repair of the dural defect. All patients recovered neurologic function after revision surgery. Conclusions: Incidental durotomy and repair causing a large compressive pseudomeningocele after spine surgery is a rare and potentially devastating event. Early postoperative magnetic resonance imaging assists in the diagnosis. Emergent decompression combined with revision dural repair surgery may result in improved outcomes. Surgeons should be cognizant of this rare cause of early postoperative major neurologic deficit in patients who had previous dural repair.
Connexin Genes in the Mouse and Human Genome

Gap junctions serve for direct intercellular communication by docking of two hemichannels in adjacent cells thereby forming conduits between the cytoplasmic compartments of adjacent cells. Connexin genes code for subunit proteins of gap junction channels and are members of large gene families in mammals. So far, 17 connexin (Cx) genes have been described and characterized in the murine genome. For most of them, orthologues in the human genome have been found (see White and Paul 1999; Manthey et al. 1999; Teubner et al. 2001; Söhl et al. 2001). We have recently performed searches for connexin genes in murine and human gene libraries available at EMBL/Heidelberg, NCBI and the Celera company that have increased the number of identified connexins to 19 in mouse and 20 in humans. For one mouse connexin gene and two human connexin genes we did not find orthologues in the other genome. Here we present a short overview on distinct connexin genes which we found in the mouse and human genome and which may include all members of this gene family, if no further connexin gene will be discovered in the remaining non-sequenced parts (about 1-5%) of the genomes.
Traffic Information Services Using FM Multiplex Broadcasting

NHK has developed an FM multiplex broadcasting system using a new digital modulation method called level controlled minimum shift keying (L-MSK) which is a kind of MSK. This system is multipath-proof, and has a transmission capacity of 16 kbps. Moreover, it has a compatibility with radio data system (RDS) because they use different frequency bands. Transmission tests were carried out to measure the performance of the 16 kbps L-MSK system in the service area of the NHK Tokyo FM station. These tests revealed that this system was superior to RDS in terms of the correct reception rates obtained in mobility. FM multiplex broadcasting using L-MSK has many merits for traffic information services.
Nasopharyngeal cancer cell death induced by high-dose gold nanoparticles

This study investigated if gold nanoparticles (AuNPs) could be used as a new therapeutic agent for NPC by evaluating their anti-tumor effect in vitro. AuNPs prepared in this study had an average diameter of 20.5 nm and they were observed under light microscopy as dark material aggregated in the cells after treatment. The AuNPs reduced cell viability in a concentration-dependant manner by Trypan Blue assay: 74.7% at 50 μM, 39.0% at 100μM, and 7.1% at 200 μM, respectively. TUNEL stain was positive in AuNP-treated cells. The AuNP possess specific imaging properties and is cytotoxic to NPC cells at high concentrations.
Design and finite element analysis of hybrid stepper motor for spacecraft applications

This paper presents the design and analysis of a 400-step hybrid stepper motor for spacecraft applications. The design of the hybrid stepper motor for achieving a specific performance requires the choice of appropriate tooth geometry. In this paper, a detailed account of the results of two-dimensional finite-element (FE) analysis conducted with different tooth width/tooth pitch ratios (t/λ) and also with different tooth shapes such as square and trapezoidal, is presented. The use of equal t/λ ratio on stator and rotor provides nearly 10% more torque than the case with unequal t/λ ratio, but with corresponding increase in detent torque and distorted static torque profile. For the requirements of maximum torque density, less-detent torque, and better positional accuracy and smooth static torque profile, different pitch slotting with equal tooth width has to be provided. From the various FE models subjected to analysis trapezoidal teeth configuration with unequal tooth pitch on the stator and rotor is found to be the best configuration and is selected for fabrication. The designed motor is fabricated and the experimental results is compared with the FE results.
Multiple Support Vector Regression for Antenna Array Characterization and Synthesis

The support vector regression framework is proposed as the basis for a new antenna array characterization technique able to model radiating structures including all the coupling effects between the elements of the array from experimental data. The obtained model can then be used to solve practical synthesis problems with high accuracy and using an appropriate cost function for template-based specification handling. A design example is presented to show the efficiency of the proposed method.
A Framework for Training Health Professionals in Implementation and Dissemination Science

The authors describe a conceptual framework for implementation and dissemination science (IDS) and propose competencies for IDS training. Their framework is designed to facilitate the application of theories and methods from the distinct domains of clinical disciplines (e.g., medicine, public health), population sciences (e.g., biostatistics, epidemiology), and translational disciplines (e.g., social and behavioral sciences, business administration education). They explore three principles that guided the development of their conceptual framework: Behavior change among organizations and/or individuals (providers, patients) is inherent in the translation process; engagement of stakeholder organizations, health care delivery systems, and individuals is imperative to achieve effective translation and sustained improvements; and IDS research is iterative, benefiting from cycles and collaborative, bidirectional relationships. The authors propose seven domains for IDS training—team science, context identification, literature identification and assessment, community engagement, intervention design and research implementation, evaluation of effect of translational activity, behavioral change communication strategies—and define 12 IDS training competencies within these domains. As a model, they describe specific courses introduced at the University of California, San Francisco, which they designed to develop these competencies. The authors encourage other training programs and institutions to use or adapt the design principles, conceptual framework, and proposed competencies to evaluate their current IDS training needs and to support new program development.
El uso de los formularios online como una herramienta ubicua de realimentación docente

En este articulo, se presentan las experiencias en la introduccion del formulario online como una herramienta muy efectiva que permite comunicar a los alumnos y los docentes con unos resultados muy positivos. El procedimiento de trabajo establecido fue el siguiente. En primer lugar, el equipo docente establece unos objetivos de aprendizaje y los distribuye en el cuatrimestre. Para cada sesion teorica, se prepara un cuestionario que explora los contenidos del dia. Este cuestionario, que se prepara en una herramienta abierta, a la que todos los alumnos tienen acceso, se presenta a los alumnos veinte minutos antes de finalizar la clase. Los alumnos pueden contestar en la clase con sus ordenadores portatiles, moviles o tabletas, sin importar el sistema operativo al tratarse de aplicaciones en la red basadas en navegadores web. Para facilitar la inclusion de alumnado que no ha podido asistir fisicamente a clase, pero sigue los contenidos a traves de los materiales que el equipo docente publica previamente a la clase, los formularios quedan abiertos hasta la medianoche de ese dia. Los resultados demuestran el alto nivel de transmision de los contenidos en una verdadera evaluacion continua que, a su vez, se percibe por el alumnado muy positivamente.
Reinvasion of Calcutta city by Aedes albopictus: the proven vector of dengue in suburban areas.

Dengue is a mosquito-borne viral disease transmitted by Aedes aegypti in cities and A. albopictus in suburban and rural areas. Dengue outbreaks occur almost regularly and sometimes reach epidemic proportions in cities and towns. Dengue endemicity in Calcutta was established for the first time in 1960, then re-established by another serosurvey in 1966. An outbreak of dengue was recently reported in the Bankura district of the city, where it has not previously been reported. With the literature suggesting a recent change in the epidemiology of dengue, probably due to the invasion of suburban and urban areas by A. aegypti and A. albopictus, respectively, a preliminary study was conducted to determine whether A. albopictus has gained a foothold in Calcutta. A larval and adult survey of Aedes species conducted from October 1995 to September 1996 in crowded areas of the city and an urban garden in central city found both A. aegypti and A. albopictus present in the surveyed areas as larvae and adults. A. albopictus, however, is competing with, and attempting to displace, A. aegypti.
Combination effect of AC‐7700, a novel combretastatin A‐4 derivative, and cisplatin against murine and human tumors in vivo

The in vivo combination effect of AC‐7700, a novel combretastatin A‐4 derivative, and cisplatin (CDDP) was examined. The combination of AC‐7700 and CDDP increased antitumor activity against murine colon 26 tumor in mice and cured the mice. This combination effect was found over wide dosage ranges of AC‐7700 (20–80 mg/kg) and CDDP (2.5–5 mg/kg). Moreover, this combination augmented antitumor activity against murine S180 and M109 tumors, and human LX‐1 and LS180 tumor xenografts in mice. The effect was the strongest when AC‐7700 and CDDP were administered simultaneously. To study this combination effect we measured the concentrations of CDDP in tumors, plasma and kidneys of the mice with colon 26 tumor. In the combination with AC‐7700, the concentration of CDDP in the tumors increased from 0.5 to 96 h after administration, but did not change or decrease in plasma or kidneys. Against human LS180 xenografts in mice, the combination similarly increased the concentration of CDDP in the tumors. These results suggest that AC‐7700 may specifically augment the accumulation of CDDP in tumors, and thus has the potential to be useful in combination chemotherapy with CDDP. (Cancer Sci 2003; 94: 200–204)
Influence of antirheumatic drugs on nitric oxide and interleukin 8 production in human articular chondrocytes.

OBJECTIVE To determine whether antirheumatic drugs can inhibit chondrocyte nitric oxide and interleukin 8 (IL-8) production. METHODS IL-1beta stimulated human chondrocytes were incubated with indomethacin, methotrexate, sulfasalazine, dexamethasone, and methylprednisolone. Nitric oxide was detected as nitrite; IL-8 was detected by a radioimmunoassay method. RESULTS Nitric oxide production was partly (< or = 50%) inhibited and IL-8 almost completely suppressed (> 80%) by dexamethasone and methylprednisolone. Sulfasalazine in pharmacological concentration and indomethacin slightly increased IL-8. No effect of methotrexate on nitric oxide or IL-8 production was found. CONCLUSION Dexamethasone and methylprednisolone are inhibitors of human chondrocyte nitric oxide production, although to a lesser extent than for IL-8 production. Indomethacin, sulfasalazine, and methotrexate had no major influence on these mediators.
Recurrent network in network intrusion detection system

This paper presents a study of network intrusion detection system based on network, and proposes a method using recurrent network in network intrusion detection system. This method can be regarded as a modified Jordan recurrent network. Recurrent network is used to extract rule set of describing intrusion, pattern and features. The rule set can then be used for intrusion detection. Experiments prove that recurrent network improve performance of intrusion detection system.
Epac and Phospholipase Cϵ Regulate Ca2+ Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II*

Recently, we identified a novel signaling pathway involving Epac, Rap, and phospholipase C (PLC)ϵ that plays a critical role in maximal β-adrenergic receptor (βAR) stimulation of Ca2+-induced Ca2+ release (CICR) in cardiac myocytes. Here we demonstrate that PLCϵ phosphatidylinositol 4,5-bisphosphate hydrolytic activity and PLCϵ-stimulated Rap1 GEF activity are both required for PLCϵ-mediated enhancement of sarcoplasmic reticulum Ca2+ release and that PLCϵ significantly enhances Rap activation in response to βAR stimulation in the heart. Downstream of PLCϵ hydrolytic activity, pharmacological inhibition of PKC significantly inhibited both βAR- and Epac-stimulated increases in CICR in PLCϵ+/+ myocytes but had no effect in PLCϵ–/– myocytes. βAR and Epac activation caused membrane translocation of PKCϵ in PLCϵ+/+ but not PLCϵ–/– myocytes and small interfering RNA-mediated PKCϵ knockdown significantly inhibited both βAR and Epac-mediated CICR enhancement. Further downstream, the Ca2+/calmodulin-dependent protein kinase II (CamKII) inhibitor, KN93, inhibited βAR- and Epac-mediated CICR in PLCϵ+/+ but not PLCϵ–/– myocytes. Epac activation increased CamKII Thr286 phosphorylation and enhanced phosphorylation at CamKII phosphorylation sites on the ryanodine receptor (RyR2) (Ser2815) and phospholamban (Thr17) in a PKC-dependent manner. Perforated patch clamp experiments revealed that basal and βAR-stimulated peak L-type current density are similar in PLCϵ+/+ and PLCϵ–/– myocytes suggesting that control of sarcoplasmic reticulum Ca2+ release, rather than Ca2+ influx through L-type Ca2+ channels, is the target of regulation of a novel signal transduction pathway involving sequential activation of Epac, PLCϵ, PKCϵ, and CamKII downstream of βAR activation.
Bending Direction Detective Fiber Sensor for Dual-Parameter Sensing Based on an Asymmetrical Thin-Core Long-Period Fiber Grating

An asymmetrical thin-core long-period fiber grating (ATC-LPFG) cascaded with an inline Mach-Zehnder interferometer (MZI) for dual-parameter sensing has been demonstrated. In addition, bending direction is also determined at the same time. A section of thin-core fiber (TCF) is fusion spliced between two single-mode fibers (SMFs). ATC-LPFG is 4 cm away from the first splicing point to form an inline MZI. The transmission spectrum consists of four dominant resonant wavelengths generated by multimode interference and loss peaks of ATC-LPFG. Two resonant wavelengths are the main loss peaks of ATC-LPFG, and additional two resonant wavelengths are caused by multimode interference. Bending direction is determined by former two resonant wavelengths; curvature and temperature sensitivities are measured by the resonant wavelength of multimode interference and ATC-LPFG. Cross sensitivity can be overcome because the resonant wavelength is generated by different mechanisms. The experimental results indicate that the sensitivities of curvature and temperature are 28.82 dB/m-1 and 67.3 pm/°C, respectively.
INTERACTION OF MONO‐ AND DIVALENT METALLIC CATIONS AND OF INDOMETHACIN ON THE MEMBRANE POTENTIAL OF VASCULAR ENDOTHELIAL CELLS in vitro

1 Endothelial cells depolarized progressively when heated for 5 h at 45° C in the presence of calcium (1 mM), cupric (0.08 mM) or ferrous (0.04 mM) ions. In the absence of these ions, heating caused only slight depolarization. Higher concentrations of these ions caused depolarization even at normal body temperature (37° C). 2 Cuprous and potassium ions, although producing depolarization at 37° C, failed to augment the depolarization due to heating to 45° C. 3 Hydrogen peroxide caused depolarization which was potentiated by the presence of calcium, cupric or ferrous ions, but not by the presence of cuprous or potassium ions. 4 Indomethacin (0.25 mM) reduced the depolarization caused by calcium, cupric or ferrous ions at 37° C and also reduced the potentiation of heat‐induced and hydrogen peroxide‐induced depolarization which these divalent metallic cations produced. However, indomethacin failed to modify the depolarization caused by cuprous or potassium ions.
A Nucleosome Surface Formed by Histone H4, H2A, and H3 Residues Is Needed for Proper Histone H3 Lys36 Methylation, Histone Acetylation, and Repression of Cryptic Transcription*

Set2-mediated H3 Lys36 methylation is a histone modification that has been demonstrated to function in transcriptional elongation by recruiting the Rpd3S histone deacetylase complex to repress intragenic cryptic transcription. Recently, we identified a trans-histone pathway in which the interaction between the N terminus of Set2 and histone H4 Lys44 is needed to mediate trans-histone H3 Lys36 di- and trimethylation. In the current study, we demonstrate that mutation of the lysine 44 residue in histone H4 or the Set2 mutant lacking the histone H4 interaction motif leads to intragenic cryptic transcripts, indicating that the Set2 and histone H4 interaction is important to repress intragenic cryptic transcription. We also determine that histone H2A residues (Leu116 and Leu117), which are in close proximity to histone H4 Lys44, are needed for proper trans-histone H3 Lys36 methylation. Similar to H4 Lys44 mutants, histone H2A Leu116 and Leu117 mutations exhibited decreased H3 Lys36 di- and trimethylation, increased histone H4 acetylation, increased resistance to 6-azauracil, and cryptic transcription. Interestingly, the combined histone H4 Lys44 and H2A mutations have more severe methylation defects and increased H4 acetylation levels. Furthermore, we identify that additional histone H2A and H3 core residues are also needed for H3 Lys36 di- and trimethylation. Overall, our results show and suggest that multiple H4, H2A, and H3 residues contribute to and form a Set2 docking/recognition site on the nucleosomal surface so that proper Set2-mediated H3 Lys36 di- and trimethylation, histone acetylation, and transcriptional elongation can occur.
An Unified Framework Based on p-Norm for Feature Aggregation in Content-Based Image Retrieval

Feature aggregation is a critical technique in content- based image retrieval systems that employ multiple visual features to characterize image content. In this paper, the p-norm is introduced to feature aggregation that provides a framework to unify various previous feature aggregation schemes such as linear combination, Euclidean distance, Boolean logic and decision fusion schemes in which previous schemes are instances. Some insights of the mechanism of how various aggregation schemes work are discussed through the effects of model parameters in the unified framework. Experiments show that performances vary over feature aggregation schemes that necessitates an unified framework in order to optimize the retrieval performance according to individual queries and user query concept. Revealing experimental results conducted with IAPR TC-12 ImageCLEF2006 benchmark collection that contains over 20,000 photographic images are presented and discussed.