Miracle-dz/UniFAR-FTUs huggingface dataset:
Fleksibilitet i strategiske processer

Hvad vil det sige at strategiske processer er fleksible? Kan man lede sådanne fleksible processer? Hvilke udfordringer, muligheder, dilemmaer, - og for den sags skyld - glæder og frustrationer er der knyttet til dette? Dette paper vil forsøge at behandle og diskutere disse spørgsmål. Dette sker med udgangspunkt i data fra et longitudinalt forskningsprojekt byggende på kvalitative metoder. Et pro-jekt der gennem halvanden år genererede empiri om, hvordan et strategiske tiltag om at arbejde med værdibaseret ledelse udvikler og udvikles gennem daglig praksis i en dansk mellemstor ser-vicevirksomhed. Empirien viser, at de strategiske tiltag fik indbygget en vis fleksibilitet i sig, idet de udviklede sig i mange forskellige og til tider også modstridende retninger, som dog alle fra hver deres perspektiv var meningsfulde. i tre vignetter, illustrerer, processer,
Rotor flux oriented control of induction machine based drives with compensation for the variation of all machine parameters

The performance of rotor ﬂux oriented induction motor drives, widely used these days, relies on the accurate knowledge of key machine parameters. In most industrial drives, the rotor resistance, subject to temperature variations, is estimated on-line due to its signiﬁcant inﬂuence on the control behaviour. However, the rest of the model parameters are also subject to slow variations, determined mainly by the operating point of the machine, compromising the dynamic performance and the accuracy of the torque estimation. This paper presents an improved rotor-resistance on-line estimation algorithm that contemplates the iron losses of the electrical machine, the iron saturation curve and the mechanical losses. In addition, the control also compensates the rest of the key machine parameters such as the leakage and magnetizing inductances and the iron losses. These parameters are measured by an oﬀ-line estimation procedure and stored in look up-tables used by the control. The paper begins by presenting the machine model and the proposed rotor ﬂux oriented control strategy. Subsequently, the oﬀ-line parameter measurement procedure is described. Finally, the algorithm is extensively evaluated and validated experimentally on a 15 kW test bench.
Clinical manifestations and antiretroviral management of HIV/AIDS patients with tuberculosis co-infection in Kramat 128 Hospital.

AIM to give a description of HIV-AIDS and tuberculosis co-infection in Jakarta, viewed from the perspective of virologic and immunologic status and the correct selection of antiretrovirals. METHODS cross-sectional descriptive study was performed on the outpatient clinic of Kramat 128, from June to July 2007. Tuberculosis infection was confirmed chest X-ray or sputum acid fast smear. Viral load was determined by Polymerase Chain Reaction (PCR) and CD4 count done by flow cytometry. The data were then analyzed using SPSS 14th and Chi Square tests for proportional data. RESULTS the study enrolled 130 patients with the prevalence of tuberculosis co-infection of 66.9% (n=87). The TB co-infected patients came with more clinical manifestations (3-4 manifestations) than the non co-infected ones (2-3 manifestations; p<0.001). They also underwent more hospitalizations (44.8% vs. 11.6%, p=0.003), had lower CD4 levels (126.49 cell/microL vs. 240.68 cell/microL; p=0.001) and more patients with CD4 levels of below 100 cell/microL (64.6% vs. 25.6%; p<0.001). The co-infected patients had more virologic failure than the non co-infected ones (38% vs. 12.5%; p=0.030), and so did the co-infected patients treated with nevirapine than those treated with efavirenz (37.8% vs. 6.3%; p=0.019). CONCLUSION tuberculosis co-infection complicated the clinical management of People Living with HIV-AIDS (PLWHA) and the antiretroviral regimen selection in these patients need to be modified. Subsequent studies were needed to confirm this study result of superior efavirenz based therapy in the TB co-infected PLWHA.
Exploring XP for Scientific Research

Can we successfully apply XP (Extreme Programming) in a scientific research context? A pilot project at the NASA Langley Research Center tested XPs applicability in this context. Since the cultural environment at a government research center differs from the customer-centric business view, eight of XPs 12 practices seemed incompatible with the existing research culture. Despite initial awkwardness, the authors determined that XP can function in situations for which it appears to be ill suited.
KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer

It has been suggested that the down-regulation of AR expression should be considered the principal strategy for the treatment of hormone-refractory prostate cancer.We have previously shown that inhibition of AR induced PI3K-independent activation of Akt that was mediated by CaMKII. In this study, we found that the CaMKII inhibitor KN-93 has a broader effect on apoptosis than just inhibition of CaMKII: first, KN-93 inhibits AR activity and induces cell death in PCa cells after androgen deprivation when many other drugs fail to kill prostate cancer cells; second, KN-93 inhibits expression of the anti-apoptotic protein Mcl-1 and induces expression of the pro-apoptotic protein PUMA; third, KN-93-mediated cell death is p53-independent; and fourth, KN-93 induces the generation of ROS. The ROS induction allows KN-93 to circumvent the activation of Akt, which occurs in prostate cancer cells under androgen deprivation, since Akt could not inhibit ROS-mediated apoptosis. KN-93 also synergistically induces cell death in combination with low doses of doxorubicin and converts the phenotype of prostate cancer cells from TRAIL-resistant to -sensitive. These data suggest that KN-93 could be used for novel therapeutic approaches when hormonal therapy has failed.
Small-signal analysis of nonideal switched-capacitor circuits

An approximate analysis method of nonideal switched capacitor circuits is introduced. The method solves the time domain presentation in steady state as well as the frequency response for nonideal circuits. Circuits may be composed of all kinds of linear components and nonlinear transistor model can be used for the switches. An example is given to demonstrate that the proposed method is efficient enough to be used in practical circuit design. Simulation results show good agreement with those obtained by conventional slow transient analysis. <<ETX>>
Retinoblastoma‐related geneRb2/p130 are rarely mutated in Burkitt's lymphoma from Brazil

It has been suggested that alterations of cell cycle genes probably contribute to the pathogenesis of endemic Burkitt's lymphoma (BL) in addition to c‐MYC translocation. Mutations disrupting the normal nuclear localization signal of the retinoblastoma‐related gene Rb2/p130 have been documented in BL cell lines and primary tumors from endemic areas. The aim of this study was to investigate the involvement of Rb2/p130 gene in the pathogenesis of sporadic BL in Brazil. DNA samples from 26 pediatric BL tumors and two healthy blood donors were screened by PCR amplification followed by single strand conformation polymorphism analysis of exons 19 and 20 (B domain) and exons 21 and 22 (C‐terminus), where most of the point mutations in the Rb2/p130 gene were identified. No abnormal band shifts were present in the samples analyzed. We concluded that mutations in exons 19–22 of the Rb2/p130 are unlikely to be involved directly in the pathogenesis of sporadic Brazilian BL. Am. J. Hematol. , 2007. © 2006 Wiley‐Liss, Inc.
Localization studies of IGFBP-2 and IGFBP-5 in the anterior compartment of the eye.

PURPOSE Insulin-like growth factor binding proteins (IGFBPs) may modulate insulin-like growth factor-I (IGF-I) action and are important regulating factors in the IGF system. Our aim was to determine the presence of IGFBP-2 and -5 in the anterior compartment of the eye and to compare the histological sites of these IGFBP proteins with the respective IGFBP mRNAs. METHODS To investigate this, immunohistochemistry was used to detect the presence of IGFBP-2 and -5 proteins, and in situ hybridization was used to determine the presence of IGFBP-2 and -5 mRNAs. The studies were performed in normal adult male Sprague-Dawley rats. Immunohistochemistry was performed by the immunoperoxidase method with polyclonal antibovine-IGFBP-2 and antihuman-IGFBP-5 antibodies. In situ hybridization was performed using 35S-radiolabelled riboprobes. RESULTS IGFBP-2 mRNA and protein were demonstrated in the outer non-pigmented ciliary epithelium, the corneal germinal epithelium and the corneal endothelium. IGFBP-2 mRNA was detected in these same histological layers of the ciliary processes and the cornea. IGFBP-5 mRNA localized to the stroma and also to the inner pigmented ciliary epithelium and IGFBP-5 protein was demonstrated in the adjacent outer nonpigmented ciliary epithelium. IGFBP-5 mRNA and protein were not demonstrated in the cornea. IGFBPs-2 and -5 were not demonstrated by immunohistochemistry in other structures of the eye. CONCLUSION We have shown co-localization of IGFBP-2 mRNA and protein and adjacent cellular localization of IGFBP-5 mRNA and proteins in the anterior compartment of the eye. The presence of IGFBP-2 and -5 in the outer ciliary epithelium suggests secretion into the aqueous humour, where they may enhance trapping of IGF-1 which may be important for lens and corneal cell survival. Our studies outlining the site of locally synthesized IGFBPs suggests specific roles in regulation of IGFs and highlights the potential importance of the IGF system in the eye.
Insulin enhances the gain of arterial baroreflex control of muscle sympathetic nerve activity in humans

Recent animal studies indicate that insulin increases arterial baroreflex control of lumbar sympathetic nerve activity; however, the extent to which these findings can be extrapolated to humans is unknown. To begin to address this, muscle sympathetic nerve activity (MSNA) and arterial blood pressure were measured in 19 healthy subjects (27 ± 1 years) before, and for 120 min following, two common methodologies used to evoke sustained increases in plasma insulin: a mixed meal and a hyperinsulinaemic euglycaemic clamp. Weighted linear regression analysis between MSNA and diastolic blood pressure was used to determine the gain (i.e. sensitivity) of arterial baroreflex control of MSNA. Plasma insulin was significantly elevated within 30 min following meal intake (Δ34 ± 6 uIU ml−1; P < 0.05) and remained above baseline for up to 120 min. Similarly, after meal intake, arterial baroreflex‐MSNA gain for burst incidence and total MSNA was increased and remained elevated for the duration of the protocol (e.g. burst incidence gain: −3.29 ± 0.54 baseline vs.−5.64 ± 0.67 bursts (100 heart beats)−1 mmHg−1 at 120 min; P < 0.05). During the hyperinsulinaemic euglycaemic clamp, in which insulin was elevated to postprandial concentrations (Δ42 ± 6 μIU ml−1; P < 0.05), while glucose was maintained constant, arterial baroreflex‐MSNA gain was similarly enhanced (e.g. burst incidence gain: −2.44 ± 0.29 baseline vs.−4.74 ± 0.71 bursts (100 heart beats)−1 mmHg−1 at 120 min; P < 0.05). Importantly, during time control experiments, with sustained fasting insulin concentrations, the arterial baroreflex‐MSNA gain remained unchanged. These findings demonstrate, for the first time in healthy humans, that increases in plasma insulin enhance the gain of arterial baroreflex control of MSNA.
Constituents of the Essential Oil from Melissa officinalis

Melissa officinalis L. subsp. inodora (Bornm.) Bornm. is one of the three subspecies of lemon balm which grows naturally in Anatolia (1). It has been used in folk medicine for many years. Melissa officinalis is a perennial plant with erect, branched stems 30—75cm and produces white flowers. Taxonomically, it differs from the other subspecies by the following features: stems and leaves are sparingly pilose with some long patent hairs; glands are numerous; leaves are truncate to subcordate at base; the middle tooth of the upper lip of the calyx is fairly distinct and triangular (1).
The co-measurement of curvature and temperature using a single LPG in a standard single mode fibre

We propose and demonstrate the use of a single long period grating (LPG), having one cladding mode that is unresponsive to changes in curvature, for simultaneous measurement of curvature and temperature. We also demonstrate that such a cladding mode can be produced at different wavelengths in a standard single mode fibre (SMF). Furthermore, we show that harmonic modes of LPGs, that are often undesirable in many applications, can now be utilized along with such a curvature-insensitive cladding mode to achieve a sensor that can measure curvature and temperature simultaneously, whilst having the capability to compensate for induced strain.
Spotlight on platelets: summary of BBTS combined special interest group autumn meeting, November 2015

This conference first addressed aspects of component quality, highlighting the role of pathogen inactivation, the role of PAS or plasma in prolonging platelet viability and acceptable storage deviations. A series of talks on the medical use of platelets covered the role of platelet transfusion in preventing intracranial haemorrhage, platelet prophylaxis in haematological patients and the new trial of the HLA Matchmaker programme to provide epitope‐matched platelets. The session on the surgical use of platelets considered the role of platelet transfusions in patients on anti‐platelet agents, major trauma and interventional procedures and also the scope for tests of platelet function to direct therapy. The conference concluded with a panel discussion highlighting key areas of general interest, including the clinical use of platelets and near patient platelet function tests.
Adjoint Logic and Its Concurrent Operational Interpretation

Adjoint logic provides a schematic way to combine multiple logics, some of which may be substructural, through modal operators that are adjoint to each other. We provide a simple formulation for adjoint logic with explicit structural rules. The adjoint logic is parameterized by a preorder of modes of truth characterizing (potential) dependence between the modes. We demonstrate that suitable choices of this preorder allow us to directly embed various logics including lax logic, judgmental S4, LNL, and intuitionistic subexponential linear logic into adjoint logic. Under the proofs-as-programs paradigm, proofs correspond to concurrent processes and cut reduction to synchronous communication. We show how to restructure the sequent calculus so that cut reduction entails asynchronous communication and give an operational interpretation that provides session-typed communication extended with multicast and distributed garbage collection.
Metabolic effects of low-dose fluconazole in healthy female users and non-users of oral contraceptives.

1. Azole antifungal agents such as ketoconazole act by inhibiting cytochrome P-450 mediated sterol synthesis in the fungal cell membrane and thus have the potential to interfere with mammalian steroidogenesis. Fluconazole is a novel orally-effective antifungal triazole which has been reported to have more specific effects on the cytochrome P-450 enzymes involved in fungal sterol synthesis. 2. Due to the potential value of systemic antifungal agents in the treatment of infections commonly occurring in women, we assessed the effect of oral fluconazole on the metabolic profile of 18 healthy premenopausal women, 10 of whom were taking combined oral contraceptives (OC). Each woman acted as her own control, being studied both before and 21-28 days after fluconazole therapy (50 mg daily), in the luteal phase of consecutive menstrual cycles. 3. The endocrinological profile included measurement of serum oestradiol, progesterone, testosterone and sex hormone binding globulin (SHBG) concentrations, short tetracosactrin adrenal stimulation test and thyroid function tests. Carbohydrate metabolism was investigated by means of an oral glucose tolerance test with measurement of plasma glucose, insulin and C-peptide concentrations. Serum lipids, lipoproteins and apolipoproteins were analysed on samples taken after an overnight fast. 4. Minor biochemical changes associated with fluconazole treatment included increases in serum thyroxine and testosterone concentrations (but not in women taking OC as well as fluconazole) and in insulin and apolipoprotein B levels (but only in women taking OC as well as fluconazole). In general, these changes were small and of no clinical significance with the values remaining within the laboratory normal range. There were no adverse side-effects. (ABSTRACT TRUNCATED AT 250 WORDS)
Stressful Events and Psychological Symptoms in Patients with Functional Urinary Disorders

The relationship between micturition, stressful events, and psychological symptoms was studied in 58 female patients with functional micturition disorders (urethral syndrome) and 21 control patients. All received three questionnaires (Symptom Questionnaire, Illness Behavior Questionnaire, and the Biographic Questionnaire). Analysis highlighted the appearance of the urethral syndrome in highly stressful situations and the increase in the patient's anxiety, depression, dysphoria, hostility, and irritability. A tendency to complain of other psychophysiologic symptoms was also noted.
oradrenergic signaling in the medial prefrontal cortex and amygdala ifferentially regulates vicarious trial-and-error in a spatial ecision-making task

In uncertain choice situations, we deliberately search and evaluate possible options before taking an action. Once we form a preference regarding the current situation, we take an action more automatically and with less deliberation. In rats, the deliberation process can be seen in vicarious trial-and-error behavior (VTE), which is a head-orienting behavior toward options at a choice point. Recent neurophysiological findings suggest that VTE reflects the rat’s thinking about future options as deliberation, expectation, and planning when rats feel conflict. VTE occurs depending on the demand: an increase occurs during initial learning, and a decrease occurs with progression in learning. However, the brain circuit underlying the regulation of VTE has not been thoroughly examined. In situations in which VTE often appears, the medial prefrontal cortex (mPFC) and the amygdala (AMY) are crucial for learning and decision making. Our previous study reported that noradrenaline regulates VTE. Here, to investigate whether the mPFC and AMY are involved in regulation of VTE, we examined the effects of local injection of clonidine, an alpha2 adrenergic autoreceptor agonist, into either region in rats during VTE and choice behavior during a T-maze choice task. Injection of clonidine into either region impaired selection of the advantageous choice in the task. Furthermore, clonidine injection into the mPFC suppressed occurrence of VTE in the early phase of the task, whereas injection into the AMY inhibited the decrease in VTE in the later phase and thus maintained a high level of VTE throughout the task. These results suggest that the mPFC and AMY play a role in the increase and decrease in VTE, respectively, and that noradrenergic mechanisms mediate the dynamic regulation of VTE over experiences. © 2015 Elsevier B.V. All rights reserved. Abbreviations: AMY, amygdala; HR, high-reward arm; LR, low-reward arm; PFC, medial prefrontal cortex; NA, noradrenaline; VTE, vicarious trial-and-error ehavior. ∗ Corresponding author at: Department of Human Health Sciences, Tokyo etropolitan University, 1-1 Minamiohsawa, Hachioji, Tokyo 192-0397, Japan. el. : +81 42 677 1111; fax: +81 42 677 2961. E-mail address: amemiyas@tmu.ac. jp (S. Amemiya). ttp://dx.doi. org/10.1016/j.bbr. 2015.09. 002 166-4328/© 2015 Elsevier B.V. All rights reserved.
Free Space Optical Interconnects Security Aspects of Future High Speed Technology

Free space optical (FSO) communication involves the use of optical or laser beams to send the information through the atmosphere. The key towards our vision is the use of FSO technology which in contrast to traditional wireless of RF technologies has lower interference footprint, can support longer range and offers higher bandwidth. In this paper we review the recent advances made in the field of data security for the FSO link along with certain aspects of FSO which make this technology most secure than the other existing technologies and discuss future research direction needed to bring FSO to the realm of practice.
Selection-Like Biases Emerge in Population Models with Recurrent Jackpot Events

Evolutionary dynamics driven out of equilibrium by growth, expansion, or adaptation often generate a characteristically skewed distribution of descendant numbers: the earliest, the most advanced, or the fittest ancestors have exceptionally large number of descendants, which Luria and Delbrück called “jackpot” events. Here, I show that recurrent jackpot events generate a deterministic median bias favoring majority alleles, which is akin to positive frequency-dependent selection (proportional to the log ratio of the frequencies of mutant and wild-type alleles). This fictitious selection force results from the fact that majority alleles tend to sample deeper into the tail of the descendant distribution. The flip side of this sampling effect is the rare occurrence of large frequency hikes in favor of minority alleles, which ensures that the allele frequency dynamics remains neutral in expectation, unless genuine selection is present. The resulting picture of a selection-like bias compensated by rare big jumps allows for an intuitive understanding of allele frequency trajectories and enables the exact calculation of transition densities for a range of important scenarios, including population-size variations and different forms of natural selection. As a general signature of evolution by rare events, fictitious selection hampers the establishment of new beneficial mutations, counteracts balancing selection, and confounds methods to infer selection from data over limited timescales.
Research on the Influence of Data Fusion on Clustering Lifespan in Wireless Sensor Networks

This paper deals with influence of the fusion of part of the related data in WSN on the energy consumption of network clustering based on the hypothesis that the data packets transmitted by cluster-head node after data fusion are the minimum with the rate distortion function theory. The study shows that node energy consumption largely depends on its location: although some nodes are comparatively distant from the sink node, they are likely to consume more energy. The study results further show that there is a trade-off between the total energy consumption of the networks and the network lifespan, i.e. even if the total energy consumption of the networks reaches its minimum, the network lifespan is not necessarily the longest.