Miracle-dz/UniFAR-FTUs huggingface dataset:
Ethanolic Extract of Moringa’s leaves (Moringa oleifera) Induce Senescence on Adenocarcinomic Alveolar Basal Epithelial Cells (A549 Cell-lines)

Moringa (Moringa oleifera) is a plant that widely used as traditional medicines. The use of Moringa as herbal medicine until now is widely studied due to its high antioxidant activity and its role as an anticancer in vitro. This study aims to determine the effect of the ethanolic extract of Moringa's leaf on the viability and senescence of lung cancer cells (A549 cell-lines). Moringa leaves were extracted with 70% ethanol solvent and tested for cell viability by MTS test. Senescence detection test were conducted by Senescence Associated-β-Galactosidase (SA-β-Gal) staining. The result of the viability test showed that the ethanolic extract of Moringa leaves was able to reduce the viability of cancer cells by 1000 µg / ml of IC50 value. The senescence detection test results used SA-β-Gal showed that the ethanolic extract of Moringa leaves was able to induce senescence up to 25% in cancer cells. The same test also performed on normal cells (MCF-12A cell-lines). The result of the assay that conducted on normal cells showed that the ethanolic extract of Moringa leaves conduct greater toxicity in cancer cells, and did not significantly induce senescence in normal cells. These results indicate the potential of Moringa as a cancer therapy agent and could be used as a basis for further research on the potential for Moringa as an anticancer.
The efect of myeloperoxidase isoforms on biophysical properties of red blood cells

Myeloperoxidase (MPO), an oxidant-producing enzyme, stored in azurophilic granules of neutrophils has been recently shown to inluence red blood cell (RBC) deformability leading to abnormalities in blood microcirculation. Native MPO is a homodimer, consisting of two identical protomers (monomeric MPO) connected by a single disulide bond but in inlammatory foci as a result of disulide cleavage monomeric MPO (hemi-MPO) can also be produced. This study investigated if two MPO isoforms have distinct efects on biophysical properties of RBCs. We have found that hemi-MPO, as well as the dimeric form, bind to the glycophorins A/B and band three protein on RBC’s plasma membrane, that lead to reduced cell resistance to osmotic and acidic hemolysis, reduction in cell elasticity, signiicant changes in cell volume, morphology, and the conductance of RBC plasma membrane ion channels. Furthermore, we have shown for the irst time that both dimeric and hemi-MPO lead to phosphatidylserine (PS) exposure on the outer lealet of RBC membrane. However, the efects of hemi-MPO on the structural and functional properties of RBCs were lower compared to those of dimeric MPO. These indings suggest that the ability of MPO protein to inluence RBC’s biophysical properties depends on its conformation (dimeric or monomeric isoform). It is intriguing to speculate that hemi-MPO appearance in blood during inlammation can serve as a regulatory mechanism addressed to reduce abnormalities on RBC response, induced by dimeric MPO.
AHP-based analysis of the risk assessment delay case study of public road construction project: An empirical study

This study proposes an empirical study of risk assessment module for public road construction projects. A case study of a conventional road construction project for new road access for a university that is located in East Coast Malaysia is adopted in this study. Seven delay factors and twenty-two sub-factors were designated from a review of literature and consultations with public road experts. The designate pair-wise questionnaire survey was distributed to the road project team in accordance with the Analytic Hierarchy Process (AHP) technique. The delay risk was assessed quantitatively by prioritizing the risk delay factors and conducting sensitivity analysis in determining the critical construction phase. This study identified the top five most prioritized factors as follows: technical (0.242), natural hazard (0.208), economic and financial (0.186), contractual (0.125), and socio-politics (0.105). The global weight obtained was ranked and the top-five of most prioritised sub-factors were determined as follows: fund risk (0.111), flood (0.099), heavy rain (0.092), unforeseen ground condition (0.086), and existing utility issue (0.076). Sensitivity analysis simplified from Expert Choice 11 programme revealed that the construction phase captured most of the risk, followed by project inception (planning stage), project design, and finally, project completion.
Association of IGFBP-3 gene polymorphism g. 3.930 G>A with birth size and birth weight in crossbred beef cattle

Crossing between cattle breeds is the one way to improve the genetic quality of cattle. Controlling crosses using genetic markers will speed up the process. The IGFBP-3 gene is a potential marker of selection due to its role in regulating growth and metabolism in cattle. The aim of this study was to determine the effect of genotype on birth size and birth weight using IBFBP-3 gene marker. A total of 32 cattle consisted of 10 Brahman Cross cattle, 14 cattle results of Brahman Cross cow crosses with Belgian Blue bull, and 8 cattle results of Brahman Cross cow crosses with Wagyu bull. Sequences of 563 bp, including the part intron 2, exon 3, and the part intron 3. Genotyping was done by sequencing method and PCR-RFLP method with the restriction enzyme PvuII. An SNP was identified at location g 3,930 (G>A). Two genotypes were observed, namely GA and GG. The genotype did not affect the performance of birth (body weight, body length, height at withers, heart girth) of the research sample. Birth traits are influenced by the cattle breed, it can be seen that Brahman Cross cattle have a body length that is bigger than the other crossbred .
Exercise with music: An innovative approach to increase cognition and reduce depression in institutionalized elderly

Concerning dementia and depression prevention, non-pharmacological interventions such as cognitive-training are currently recommended as an alternative for the elderly, for the reason that they produce less side effects. Based on this perspective, the aim of this study was to identify the effects of movement with music upon cognition and depression in institutionalized elderly. A longitudinal study was conducted from November 2013 to February 2014 in Vila Real, Portugal. The sample included thirty-nine institutionalized healthy seniors over 60 years of age who were divided into two groups: music plus movement (MMG, n=20, 80.65±6.59 years) and cognitive training group without music (CTG, n=19, 83.68±6.54 years); both groups were submitted to an intervention period (4 months, 3x/week, 90min/session). Before and after the intervention period the following instruments were applied in both groups: Mini Mental State Examination (MMSE), Raven’s Coloured Progressive Matrices (MPCR), and Geriatric Depression Scale (GDS-27). Both interventions proved to improve cognitive function, mental ability and depression. The interaction effect between programs’ intervention and time was observed in language, mental ability, and depression indicators. Considering these variables, the magnitude of variation between moments was higher in the MMG in language and depression with a high effect value for depression (η2ρ =.342). In conclusion, this study emphasises the role of music and movement as a broad intervention in mental health, acting simultaneously as cognitive training and an anti-depressive.
Interactive comment on “Seasonal characteristics, formation mechanisms and source origins of PM2.5 in two megacities in Sichuan Basin, China” by Huanbo Wang et al

R: Based on this and another reviewer’s critical comments, we have added many indepth analyses in the revised manuscript. These include: (1) providing gaseous precursors and meteorological parameters data to explain the seasonal variation trends of PM2.5 and its chemical components; (2) conducting air mass back trajectory analyses to illustrate the influence of topography on PM2.5 pollution in Sichuan Basin; (3) adding deliquescence relative humidity (DRH) analysis for the summer season to explain the different NO3concentrations at the two sites, and (4) comparing the characteristics of PM2.5 pollution episodes in Sichuan Basin with those in the other regions of China.
ENVIRONMENTAL FACTORS INFLUENCING THE HEALTH AND PRODUCTIVITY OF PHANG-NGA BAY

The Andaman Sea of Thailand borders the west coast ofsouthern Thailand. The Sea venues runoffand of fishore upwelling supporting rich fisheries habitats. The richness is further enhanced by environmental regimes both in the northern and southern Andaman Sea. Phang-nga Bay is a rich ecosystem, located in between these regimes of the Andaman Sea. The Bay is one of Southeast Asias most valuable assets, characterized by its extensive estuarine ecosystem and dense mangrove forests. It is blessed with a pleasant tropical climate and high rainfall. The rainfall enriches the Bay's nutrients tbatsupport extensive aquaculture and a wide diversity of marine life, The high potential for economic benefits from these resources has led to hea y exploitation andst resses on the Bay's ecosys tem. This paper reviews the s t a tus of Phang-nga Bay's environmenta l resources and ecosys tem processes tha t help determine its health andproductivity. These include beddepositedsediment, distribution of grain size andsortingin relation to its coexisting trace element and CaCO3 as well as mangrove progradation. Water quality characteristics and their seasonal variations are highlighted together with the application of a twodimensional, vertically averaged tidal circulation-dispersion model. The mode/simulation showed residual tidal eddies in relation to wind-driven circulation vis-a-vis seasonal change. The residence time of both seawater and runoff water in the Bay were estimated to gain insight into the accumulation anddilution of wasteloads in the Bay.
Structure of the Calx-β domain of the integrin β4 subunit: insights into function and cation-independent stability

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Inheritance of maize (Zea mays L.) leaf traits

Maize leaf plays an important role in the synthesis of organic compounds. It hosts the interception of light energy and conversion to organic energy, and the capture and assimilation of carbon dioxide in order to produce food. In this study, we explore the heritability of the maize leaf length, leaf width, and the number of leaves of two maize genotypes, JNE and BLC. The estimates of heritability varied from 0.2 to 0.44. Only estimates for leaf width and leaf length are significant. The coefficients of genotypic correlation were between 0.45 and 0.66, and like the estimates of heritability, only the genotypic correlations between parents and offspring are significant for leaf length and leaf width of the two genotypes. The estimates of degree of genetic determination also known as heritability in the broad sense are all high. They range between 0.52 and 0.85. We determined a significance criterion for the degree of genetic determination, the critical value at the level of significance = 0.05. We evaluated three methods for finding the critical value. With two methods based on the algebraic transformation of a function of the Snedecor’s F and a simulation based on that function of F, it can be concluded that the estimates of the degree of genetic determination of leaf width of both the JNE and BLC genotypes are significant. With the third method that is based on fitting a Beta distribution, the critical value helped to conclude that none of the estimates of the degree of genetic determination is significant. The Pearson coefficients of correlation between plant height and all three leaf traits showed significant correlation between them, except leaf length and number of leaves. Key words: Heritability, genotypic correlation, degree of genetic determination, genotype, significance test.
Interactive comment on “ Relevance of aboveground litter for soil organic matter formation – a soil profile perspective

This is a nice straightforward presentation of a field study investigating the fate of surficial litter-derived carbon as it enters and travels down the soil profile. The introduction presents a good overview of the current scientific understanding and of the study objectives. As mentioned by previous reviewers, it may benefit from acknowledging past studies using radioactive carbon, as well as the few studies using stable carbon to follow the fate of surface litter. The methodological approach is described in sufficient detail, and the results are concisely presented (thank you! ). This paper presents a case study-results from a specific soil. There is still value in getting the work published as is, as I agree with the authors that quantitative information on the fate of carbon inputs after they enter soils is still mostly missing. Out of curiosity, why was that particular study
THE ANTIOXIDANT EFFECTS OF VITAMIN C ON LIVER ENZYME (SGPT) ACTIVITY IN RATS UNDER PARAQUAT TOXICITY

Recent studies on exposure assessment and health effects have shown paraquat (PQ) to have serious deleterious effects on certain organs. Activities are now geared towards enhancing the antioxidant system to counter the destructive effects of reactive oxygen species (ROS) initiated by paraquat in the body. This study, therefore, is aimed at understudying vitamin C (antioxidant) ability to quench the ROS effects of paraquat on cells, using the enzyme SGPT as an index. A 2mls sub-lethal dose of the toxicant PQ was administered intraperitoneally (ip) to the animals, once a month, over a period of three months. The test subgroups (A2, B2, C2, and D2) were maintained with vitamin C solution (200mg/l) and the other subgroups (A1, B1, C1 and D1) were maintained with water during study period. Four animals per subgroup at the end of each month were decapitated and blood samples taken for SGPT enzyme activity determination. The results obtained indicated that the test subgroups without vitamin C administration had a very-significant elevation of SGPT activities as against the subgroups with vitamin C administration, from month 1 (P≤0.01) to month 3 (P≤0.001). The control subgroup on vitamin C maintenance (A2) had a non-significant elevation of SGPT enzyme activities when compared to the subgroup without vitamin C (A1) all through the study period. The between groups/subgroups comparison showed a dose and time dependent elevations in enzyme activities. The within groups/subgroups indicated that vitamin C treated rats had less elevated enzyme activities when compared to the rats treated with paraquat without vitamin C. With these results it could be concluded that vitamin C when administered at moderate doses and maintained for a long duration could be used as a life saving medication in patient under toxic insult.
Interactive comment on “Investigating the Impacts of Saharan Dust on Tropical Deep Convection Using Spectral Bin Microphysics” by

To better understand the impacts of dust aerosols on deep convective cloud (DCC) systems reported by previous observational studies, a case study in the tropical eastern Atlantic was investigated using the Weather Research and Forecasting (WRF) model coupled with a Spectral Bin Microphysics (SBM) model. A detailed set of ice nucleation parameterizations linking ice formation with aerosol particles have been implemented in the SBM. Increasing IN 10 concentration in the dust cases results in the formation of more numerous small ice particles in the heterogeneous nucleation regime (between -5°C and -38°C) compared to the background (Clean) case. Convective updrafts are invigorated by increased latent heat release due to depositional growth and riming of these more numerous particles, which results in increased overshooting and higher convective core top heights. Competition between the more numerous particles for available water vapour during diffusional growth and available smaller crystals/drops during collection reduces particle 15 growth rates and shifts precipitation formation to higher altitudes in the heterogeneous nucleation regime. Homogeneous ice formation is reduced in the dust cases as IN concentration is increased, due to more liquid drops converting to ice by freezing or riming before reaching -38°C and reduced peak supersaturation values from increased diffusional growth. Local IN activation in the stratiform regime contributes to increased cloudiness in the heterogeneous nucleation regime. A greater number of large snow particles form in the dust cases, which are transported from the core into the stratiform regime and 20 sediment out quickly. Together with reduced homogeneous ice formation, fewer cloud ice particles form within and/or are transported into the anvil regime. This shifts the stratiform/anvil cloud occurrence frequency to warmer temperatures and reduces anvil cloud extents. Total surface precipitation accumulation is reduced proportionally as IN concentration is increased, due to less efficient graupel formation reducing convective rain rates. Stratiform precipitation accumulation is increased due to greater snow formation and growth, but does not counteract the reduced convective accumulation. Riming 25 efficiency in the dust cases is reduced due to smaller cloud ice crystals, resulting in smaller graupel sizes overall. Ice particle aggregation occurs earlier in the simulation and over a wider temperature range in the dust cases, which increases snow formation in the heterogeneous nucleation regime. Radar reflectivity values are increased in the dust cases at temperatures below 0°C in both the convective and stratiform regimes due to more large snow particles. More numerous small ice/graupel particles that form in the heterogeneous nucleation regime in the dust cases melt and reduce reflectivity values in the 30 convective core near the surface, consistent with case study observations.
MODERN ALGORITHMS TO IDENTIFY PLAGIARISM

Nowadays information technology industry is growing extremely fast. To solve business needs, address researcher demand for problem solving a lot of programs are built from scratch. However, not all developers are fair enough to align their products with the corresponding library or another (open source) product licenses, i.e. copyrights are being violated, intentionally or due to familiarization with another source code. To address this issue in past decade multiple plagiarism detection techniques and algorithms were invented. Despite the fact, that many of them are capable of code comparison on meta-level, modern Integrated Development Environments (IDEs) provide convenient way to modify program source code without actual re-writing, preserving the original code workflow and avoiding plagiarism detection. This paper will compare and identify available approaches to apprehend this issue, as well as provide insights for the future this problem mitigation.
Фенольные соединения лавра благородного (обзор)

One of the most famous plants of the laurel family (Lauraceae) is Laurus nobilis L. The aim of the study was to review scientific information on the study of phenolic compounds of wild-growing and cultivated Laurus nobilis L. Materials and methods . The study was performed using information retrieval (PubMed, ScholarGoogle) and library databases (eLibrary, Cyberleninca), as well as ResearchGate application for semantic search. The research methods are analysis and synthesis of the scientific literature data for the period from 2000 up to the present. Results . The data presented in the review show that leaves, fruits, and shoots of Laurus nobilis L. are valuable sources of phenolic compounds, such as phenolic acids, flavonoids, and proanthocyanidins. The quantitative content of these groups of substances varies depending on the collecting ground, the source of raw materials (cultivated or wild plants), the time (phase) of their harvesting, the method of drying, extraction from raw materials, etc. Phenolic compounds exhibit a pronounced antioxidant and antiradical activity, have an inhibitory effect on NO production, sodium-potassium adenosine triphosphatase, on tumour cell lines (HeLa, MCF7, NCI-H460 and HCT15), and are characterised by an antibacterial action against gram-positive and gram-negative bacteria. Conclusion . The analysis of the available scientific information showed that the phenolic compounds of Laurus nobilis L. are one of the main groups of the active compounds of this plant. The use of this information is essential for the development of new effective medicines based on the raw materials of Laurus nobilis L.
penelitian dengan analisis deskriptif kualitatif berdasarkan teori dan penelitian terapan di lapangan. Pengumpulan data digunakan untuk memperoleh hal-hal khusus yang berkaitan dengan penelitian melalui observasi wawancara. Dari hasil penelitian dan pembahasan menunjukkan bahwa kinerja karyawan di h

collection wasc onducted In this study Pastry section Aryaduta Palembang. Research methods with qualitative descriptive analysis based on the theory and applied research in the field. The collection of data is used to obtain the particulars relating tothe research through observation, interviews. From the results of research and discussion shows that performance of employees in the hotel pastry Aryaduta Palembang has been greatly support the smooth operation of the hotel. This is shown By the performance of employees pastry that can produce the highest quality products. All operations related to the pastry section went well and the employees working order in accordance with standard operating procedures that have beendetermined.
DISAGGREGATED INFLATION AND ASYMMETRIC OIL PRICE PASS‐THROUGH IN NIGERIA

The oil price – inflation relationship has continued to significantly feature in the macroeconomic debate, a situation that is guaranteed by nineteen oil market disruptions experienced by the world over the last forty years (Verleger, 2019). The debate on the dynamic behavior between oil price and domestic inflation is an ongoing process and recent literature indicated that the relationship shows non-linearities, which could have some implication for monetary policymaking. We estimate NARDL models of the link between oil price and inflation decomposed into CPI sub-indices of food, core, other energy and transport and find support for long-run asymmetry in relation to oil price shocks as well as incomplete pass-through of oil price to inflation. Our results suggest that it takes within 4 - 8 quarters for the disaggregated inflation to converge to its long-run equilibrium after a negative or positive unitary oil price shock. Hence, we conclude that there is the need to boost domestic oil refining capacity and fostering of competition in the domestic market as well as unlocking investment in other bio-fuels and other low-cost energy products to reduce energy imports in Nigeria.
Network Effects, Consumer Expectations and Ride-hailing Rivalries: Understanding How Platform Entries Influence New Car Sales

The gradual entries of ride-hailing platforms across China provide us with a unique opportunity to examine the interplay among network effects, consumer expectations and platform competition in the sharing economy. While recent empirical evidence shows that the initial entry of Didi Chuxing (the leading ride-hailing platform in China) positively impacts new car sales in the short run, our study demonstrates that, once the time window of investigation is expanded from one year to three years, the impacts of entries on new car sales turn negative. In addition, our analysis provides evidence suggesting that intensified competition resulting from platform rivalries can boost new car sales to alleviate the negative impacts in the short run.