Miracle-dz/UniFAR-FTUs huggingface dataset:
Providing Security to Mobile Video Streaming and Video Sharing in the Cloud

Demand on video traffic over mobile network is increasing in year on year basis, wireless link capacity cannot satisfying the traffic requirement. The difference in the traffic demand and the link capacity with varying link conditions results in poor quality of videos such as intermittent disruptions and long buffering time over mobile networks. Due to such environments, we propose a new mobile video streaming and sharing system, which efficiently stores videos on the cloud (VC) and construct agent (subVC) for each mobile user at client side to offer “non-terminating” video streaming. And also proposed system will monitor the social network communication among mobile users and their private agent prefetch videos in advance according to social activities. The security of videos and private data of user is provided by using AES algorithm and secure key exchange by using Diffie Hellman Key Exchange algorithm.
Intraoperative hypothermia and blood loss: are antifibrinolytic exposure and variations in anesthetic technique possible confounders?

To the Editor:—I read with great interest the excellent article by Dr. Rajagopalan et al. detailing their meta-analysis to investigate the relation between mild perioperative hypothermia, blood loss, and transfusion. Their analysis demonstrated that mild hypothermia increases blood loss by approximately 16% and increases the risk for transfusion by approximately 22%. My first question to the authors is whether perioperative antifibrinolytic exposure has confounded the results of the meta-analysis. For example, tranexamic acid was used in the one cardiac study that did not show increased blood loss or transfusion due to hypothermia. Was antifibrinolytic therapy a major confounder across studies included in the meta-analysis? Does antifibrinolytic exposure explain the studies that documented no increased bleeding or transfusion risk due to mild hypothermia? My second question to the authors is whether these negative studies are confounded by hemostatic variations in anesthetic technique, such as induced hypotension and/or regional anesthesia. I congratulate Dr. Rajagopalan et al. on their excellent article that has further highlighted the importance of perioperative euthermia. I look forward to their comments. John G. T. Augoustides, M.D., F.A. S.E. , Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. yiandoc@hotmail.com
Theory of Profit: The Islamic Viewpoint

Much of the literature on Islamic economics in the realm of distribution has so far been mainly concerned with questions relating to interest. Rent and, at times, wages have also been discussed. But the subject of profit continues to remain in a state of almost total neglect. References to it have made occasional appearance in the discussions on mudarabah or the principles of trade. The present paper, therefore, makes a preliminary attempt to look at profit theory from the Islamic viewpoint.
The effect of various levels of ractopamine hydrochloride on the performance and carcass characteristics of finishing swine.

Six trials involving 888 pigs (Study 1) and three trials involving 360 pigs (Study 2) were conducted at various geographical locations in the U.S. and Canada to evaluate the effect of ractopamine hydrochloride on the performance and carcass characteristics of finishing swine. All trials were conducted using a randomized complete block design. Trial data were pooled within study for statistical analysis. Pigs averaged approximately 64.5 kg (Study 1) and 65.9 kg (Study 2) initially and had ad libitum access to a 16% crude protein corn-soybean meal or barley-soybean meal diet. Ractopamine was included in the diet at 0, 2.5, 5, 10, 20 or 30 ppm (Study 1), or at 0, 5, 10, 15 or 20 ppm (Study 2); diets were fed for an average of 45 d (Study 1) and 50 d (Study 2) to a final weight of about 104.3 kg (Study 1) and 106.6 kg (Study 2). Carcass dissection data were collected in three of the six trials in Study 1 (0, 5 and 20 ppm ractopamine) and in all three trials in Study 2 (0, 5, 10, 15 and 20 ppm ractopamine). All ractopamine levels improved (P less than .05) ADG and feed: gain (Studies 1 and 2) above those of control pigs. Ractopamine levels of 10 to 30 ppm (Studies 1 and 2) improved (P less than .05) dressing percentage over controls. Pigs fed ractopamine at 5 and 20 ppm (Study 1) and 10, 15 and 20 ppm (Study 2) had increased (P less than .05) dissected leanness compared with controls. (ABSTRACT TRUNCATED AT 250 WORDS)
Review: Aldosterone Inhibition Reduces the Risk of Sudden Cardiac Death in Patients with Heart Failure

Sudden cardiac death (SCD) accounts for over 450,000 deaths annually in the USA. Sudden death is estimated to account for approximately 50% of all deaths from cardiovascular causes. Total cardiac mortality has decreased from 728,115 in 1989 to 719,456 in 1999 but the percentage of deaths that are sudden has actually increased from 38% to 47%. Prevention of SCD in patients with risk factors is a high priority for public health professionals. Aldosterone has been shown to be associated with myocardial inflammation, endothelial dysfunction and fibrosis. There is evidence from clinical trials suggesting the endothelial dysfunction and fibrosis. There is evidence from clinical trials suggesting role of aldosterone inhibition in prevention of SCD. We reviewed the potential mechanisms and discuss the clinical implications of Randomised ALdactone Evaluation Study (RALES) and Eplerenone Neurohormonal Efficacy and Survival Study (EPHESUS). The use of aldosterone receptor blockers had an overall effect of 21% risk reduction in SCD. Appropriate monitoring and counselling is essential while using either of the aldosterone inhibitors.
Joint 3D Human Motion Capture and Physical Analysis from Monocular Videos

Motion analysis is often restricted to a laboratory setup with multiple cameras and force sensors which requires expensive equipment and knowledgeable operators. Therefore it lacks in simplicity and flexibility. We propose an algorithm combining monocular 3D pose estimation with physics-based modeling to introduce a statistical framework for fast and robust 3D motion analysis from 2D video-data. We use a factorization approach to learn 3D motion coefficients and join them with physical parameters, that describe the dynamic of a mass-spring-model. Our approach does neither require additional force measurement nor torque optimization and only uses a single camera while allowing to estimate unobservable torques in the human body. We show that our algorithm improves the monocular 3D reconstruction by enforcing plausible human motion and resolving the ambiguity of camera and object motion. ,,,,,,The performance is evaluated on different motions and multiple test data sets as well as on challenging outdoor sequences.
Decision Making Before the Location Model of Distribution Center

Appropriate locations for distribution centers benefit both distribution centers and their clients. Many location models of distribution centers base on the assumption that the companies that the distribution center serves are known. Few literatures touch on the issue that if the right companies have been found as the service objects for the distribution center. This paper believes the better way is to find the right service clients first, and then, build location model based on it. And this paper focuses on the identification of the service clients and other decisions can be made based on the identification result. In order to find the right clients for distribution centers a network which can reflects the transport relationships among companies is created first. Then the companies that should share logistics service are identified through community detection method. The companies belonging to a same community of the network may become the right service clients for a distribution center.
One‐thousand‐and‐one substrates of protein kinase CK2?

CK2 (formerly termed “casein kinase 2”) is a ubiquitous, highly pleiotropic and constitutively active Ser/Thr protein kinase whose implication in neoplasia, cell survival, and virus infection is supported by an increasing number of arguments. Here an updated inventory of 307 CK2 protein substrates is presented. More than one‐third of these are implicated in gene expression and protein synthesis as being either transcriptional factors (60) or effectors of DNA/RNA structure (50) or translational elements. Also numerous are signaling proteins and proteins of viral origin or essential to virus life cycle. In comparison, only a minority of CK2 targets (a dozen or so) are classical metabolic enzymes. An analysis of 308 sites phosphorylated by CK2 highlights the paramount relevance of negatively charged side chains that are (by far) predominant over any other residues at positions n+3 (the most crucial one), n+1, and n+2. Based on this signature, it is predictable that proteins phosphorylated by CK2 are much more numerous than those identified to date, and it is possible that CK2 alone contributes to the generation of the eukaryotic phosphoproteome more so than any other individual protein kinase. The possibility that CK2 phosphosites play some global role, e.g., by destabilizing α helices, counteracting caspase cleavage, and generating adhesive motifs, will be discussed. —Meggio, F. , Pinna, L. A. One‐thousand‐and‐one substrates of protein kinase CK2? FASEB J. 17, 349–368 (2003)
The Impact of Aging on Vasa Nervorum, Nerve Blood Flow and Vasopressin Responsiveness

Abstract: Objective: Aging impacts microvessels in a number of tissue beds. Vasopressin acts as a vasoconstrictor in most blood vessels but may also cause vasodilation. We evaluated the role of aging and vasopressin in the regulation of nerve blood flow (NBF) in rat peripheral nerve. Methods: We undertook a dose-response study to examine the impact of aging on resting NBF and its vasoreactivity to vasopressin. Nerve blood flow was measured using microelectrode hydrogen polarography. Argininevasopressin was administered both intra-arterially and topically. Results: In young adult rats (two months old) topical epineurial application of arginine-vasopressin produced a concentration-dependent reduction of NBF (ED50= 3.8 X 10-5 mol/L). Intra-arterial arginine-vasopressin also reduced NBF. Nerve blood flow was lower in aged rats (12 months old) and less responsive to topically applied vasopressin. The aging group had significantly higher concentrations of vasopressin in plasma than did the younger group. Conclusions: The results suggest that vasopressin constricts vessels in peripheral nerve and that there is an age related decline in the vasoconstrictive response to vasopressin. There may be a reduction in receptor sensitivity in vascular smooth muscle cells in peripheral nerve with increasing age.
Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma.

PURPOSE This study compared denosumab, a fully human monoclonal anti-receptor activator of nuclear factor kappa-B ligand antibody, with zoledronic acid (ZA) for delaying or preventing skeletal-related events (SRE) in patients with advanced cancer and bone metastases (excluding breast and prostate) or myeloma. PATIENTS AND METHODS Eligible patients were randomly assigned in a double-blind, double-dummy design to receive monthly subcutaneous denosumab 120 mg (n = 886) or intravenous ZA 4 mg (dose adjusted for renal impairment; n = 890). Daily supplemental calcium and vitamin D were strongly recommended. The primary end point was time to first on-study SRE (pathologic fracture, radiation or surgery to bone, or spinal cord compression). RESULTS Denosumab was noninferior to ZA in delaying time to first on-study SRE (hazard ratio, 0.84; 95% CI, 0.71 to 0.98; P = .0007). Although directionally favorable, denosumab was not statistically superior to ZA in delaying time to first on-study SRE (P = .03 unadjusted; P = .06 adjusted for multiplicity) or time to first-and-subsequent (multiple) SRE (rate ratio, 0.90; 95% CI, 0.77 to 1.04; P = .14). Overall survival and disease progression were similar between groups. Hypocalcemia occurred more frequently with denosumab. Osteonecrosis of the jaw occurred at similarly low rates in both groups. Acute-phase reactions after the first dose occurred more frequently with ZA, as did renal adverse events and elevations in serum creatinine based on National Cancer Institute Common Toxicity Criteria for Adverse Events grading. CONCLUSION Denosumab was noninferior (trending to superiority) to ZA in preventing or delaying first on-study SRE in patients with advanced cancer metastatic to bone or myeloma. Denosumab represents a potential novel treatment option with the convenience of subcutaneous administration and no requirement for renal monitoring or dose adjustment.
It's not what you hear, it's the way you think about it: appraisals as determinants of affect and behaviour in voice hearers

Background Previous studies have suggested that beliefs about voices mediate the relationship between actual voice experience and behavioural and affective response. Method We investigated beliefs about voice power (omnipotence), voice intent (malevolence/benevolence) and emotional and behavioural response (resistance/engagement) using the Beliefs About Voices Questionnaire – Revised (BAVQ-R) in 46 voice hearers. Distress was assessed using a wide range of measures: voice-related distress, depression, anxiety, self-esteem and suicidal ideation. Voice topography was assessed using measures of voice severity, frequency and intensity. We predicted that beliefs about voices would show a stronger association with distress than voice topography. Results Omnipotence had the strongest associations with all measures of distress included in the study whereas malevolence was related to resistance, and benevolence to engagement. As predicted, voice severity, frequency and intensity were not related to distress once beliefs were accounted for. Conclusions These results concur with previous findings that beliefs about voice power are key determinants of distress in voice hearers, and should be targeted specifically in psychological interventions.
Men's knowledge about prostate cancer: a case study of rural Mhondoro‐Ngezi, Kadoma District, Zimbabwe

Men in Zimbabwe, like elsewhere in the world, suffer from prostate cancer. Yet ironically, men's awareness of the disease and comprehensive knowledge about the signs and symptoms, screening methods and the age groups predisposed to the risk of the diseases has remained poorly understood. Utilising a survey of 500 men aged between 15 and 79 years, 12 key informant interviews and seven focus group discussions in Mhondoro-Ngezi, the study established that men's awareness and comprehensive knowledge about prostate cancer is very low and marred with misconceptions. Informal sources of communication, especially friends, continue to be the major sources of information about prostate cancer, while formal sources are passive. The aforementioned findings imply that playmakers in the health delivery programmes have an overdue responsibility to rescue men from the catastrophic trap so that they freely enjoy their rights to good health. There is also need for accelerated information, education and communication regarding male reproductive cancers to cater for the future welfare of men given that they are drivers of national economies in their various capacities. Failure to do so would mean that men's reproductive health-seeking behaviour regarding early screening and treatment of prostate cancer will forever remain compromised.
A fusion protein derived from Moraxella catarrhalis and Neisseria meningitidis aimed for immune modulation of human B cells

Moraxella IgD-binding protein (MID) is a well characterized trimeric autotransporter that specifically targets the IgD of B cells. We fused the membrane anchor of the meningococcal autotransporter NhhA with the IgD-binding region of MID (aa 962–1200) to create a chimeric protein designated as NID. The aim was to use this specific targeting to provide a better vaccine candidate against meningococci, in particular serogroup B by enhancing the immunogenicity of NhhA. NID was thereafter recombinantly expressed in E. coli. The NID-expressing E. coli bound to peripheral B lymphocytes that resulted in cellular activation. Furthermore, we also successfully expressed NID on outer membrane vesicles, nanoparticles that are commonly used in meningococcal vaccines. This study thus highlights the applicability of the menigococcal-Moraxella fusion protein NID to be used for specific targeting of vaccine components to the IgD B cell receptor.
famRCA-RACE: A ROLLING CIRCLE AMPLIFICATION RACE FOR ISOLATING A FAMILY OF HOMOLOGOUS cDNAs IN ONE REACTION AND ITS APPLICATION TO OBTAIN NAC GENES TRANSCRIPTION FACTORS FROM CROCUS (CROCUS SATIVUS) FLOWER

We describe an improvement of the RCA-RACE (rolling circle amplification—rapid amplification of cDNA ends) method, called family RCA-RACE (famRCA-RACE). The method is based on the generation of circular cDNA fragments, followed by rolling circle amplification of the circular cDNA using ϕ29 DNA polymerase and the application of PCR using degenerate outworking primers, designed for a conserved region of homologous genes, that allows the isolation of homologous cDNA sequences expressed in the mRNA preparation in a single polymerase chain reaction (PCR). As an example we present the isolation of seven NAC-like transcription factors cDNA sequences expressed in Crocus sativus flower, used for saffron production. Sequence alignment revealed that CsatNAC proteins contain the typical domain structure of plant NAC proteins, consisting of the conserved N-terminal NAC domain used to design the primers and the five subdomains. Phylogenetic analysis revealed that CsatNAC proteins fall in subgroup I of the NAC family of proteins.
Communication patterns of primary care physicians.

OBJECTIVES To use audiotape analysis to describe communication patterns in primary care, to relate these to ideal relationship types as described in the literature, and to explore the patterns' relationships with physician and patient characteristics and satisfaction. DESIGN Description of routine communication in primary care based on audiotape analysis and patient and physician exit questionnaires. SETTING A total of 11 ambulatory clinics and private practices. PARTICIPANTS The participants were 127 physicians and 537 patients coping with ongoing problems related to disease. MAIN OUTCOMES MEASURES Roter Interactional Analysis System (RIAS) and patient and physician exit satisfaction questionnaires. RESULTS Cluster analysis revealed 5 distinct communication patterns: (1) "narrowly biomedical," characterized by closed-ended medical questions and biomedical talk occurring in 32% of visits; (2) "expanded biomedical," like the restricted pattern but with moderate levels of psychosocial discussion occurring in 33% of the visits; (3) "biopsychosocial," reflecting a balance of psychosocial and biomedical topics (20% of the visits); (4) "psychosocial," characterized by psychosocial exchange (8% of visits); and (5) "consumerist," characterized primarily by patient questions and physician information giving (8% of visits). Biomedically focused visits were used more often with more sick, older, and lower income patients by younger, male physicians. Physician satisfaction was lowest in the narrowly biomedical pattern and highest in the consumerist pattern, while patient satisfaction was highest in the psychosocial pattern. CONCLUSIONS Primary care communication patterns range from narrowly biomedical to consumerist patterns and parallel the ideal forms of patient-physician relationships described in the literature.
[Lox-1--an actor in cardiovascular disease?].

BACKGROUND Among risk factors such as smoking, hypertension and LDL cholesterol, oxidized LDL (ox-LDL) has emerged as a new and interesting factor. Scavenger receptors are a group of cell-surface receptors located on various cell types within the vessel wall with special affinity for ox-LDL. Of all the scavenger receptors involved in coronary heart disease, the lectin-like oxidized low-density lipoprotein receptor (LOX-1) is probably the most important. MATERIAL AND METHODS This article provides a general overview of the scavenger receptors, with special emphasis on LOX-1 and its role in hypertension, heart failure, atherosclerotic heart disease and diabetes mellitus, based on the literature and our own published data. RESULTS AND INTERPRETATION LOX-1 is located in various cell types within atherosclerotic plaque, in humans as well in animals, and it accumulates during the progression of the plaque. The receptor is highly expressed in hypertension, hyperhomocysteinaemia and diabetes mellitus. Data indicate that there is a complex interaction between LOX-1 and a number of different processes, such as inflammation, lipid accumulation and oxidative stress. In addition, LOX-1 seems to have therapeutic potential, and a prospective treatment aiming to reduce the level of LOX-1 may be important in the development of atherosclerotic disease, such as coronary heart disease.
Chaos Analysis of Discharge Current on Phenolic Resin under Reduced Pressure

The experiment of this research was carried out on a phenolic resin laminate in accordance with IEC60112 under a reduced pressure. In order to assess the performance in the tracking test, the chaos theory was adopted. According to the characteristics of statistical self-similarity and complexity of discharge current in the tracking test, the fractal dimension was calculated based on the G-P algorithm, and the strange attractor was reconstructed by using Takens theory. The C-C method was used to estimate the delay time. Obtained results show that the correlation dimension and the Lyapunov exponents show a similar tendency with the decrease of the ambient pressure
Different positions of tropomyosin isoforms on actin filament are determined by specific sequences of end‐to‐end overlaps

Tropomyosins are dimeric rod‐like proteins which polymerize along actin filaments and regulate interactions with other actin‐binding proteins. Homologous sequences responsible for the binding of tropomyosin to consecutive actin monomers repeat along tropomyosin and are called actin‐binding periods. In this work, the localization of tropomyosin isoforms on actin alone and on actin–myosin complex was evaluated by measuring Förster resonance energy transfer (FRET) distances between a donor (AEDANS) attached to either the N‐terminal actin‐binding period 1 or to the central actin‐binding period 5 and an acceptor (DABMI) bound to actin's Cys374. The recombinant α‐tropomyosin isoforms – TM2, TM5a, and TM1b9a, used in this study, had various amino acid sequences of the N‐ and C‐termini forming the end‐to‐end overlap. Although the sequences of actin‐binding period 5 of the three isoforms were identical, the donor–acceptor distances calculated for each isoform varied between 38.6 and 41.5 Å. Differences in FRET distances between the three tropomyosin isoforms labeled in actin‐binding period 1 varied between 34.8 and 40.2 Å. Rigor binding of myosin heads to actin increased all measured distances. The degree and cooperativity of myosin‐induced shift was different for each of the isoforms and actin‐binding periods. The structural differences correlate with cooperative regulation of actin‐activated S1 ATPase by the three tropomyosins. The results indicate that amino acid sequences of the end‐to‐end overlap determine specific orientation of tropomyosin isoform on actin. This can be important for steric and cooperative regulation of the actin filament and determine functional specificity of multiple tropomyosin isoforms present in eucaryotic cells. © 2011 Wiley‐Liss, Inc.