Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative randomised study of GlideScope® video laryngoscope versus flexible fibre-optic bronchoscope for awake nasal intubation of oropharyngeal cancer patients with anticipated difficult intubation

Background and Aims: Awake flexible fibre-optic bronchoscope (FFS) is the standard method of intubation in difficult airway in oral cancer patients. We decided to evaluate GlideScope® video laryngoscope (GL) for intubation as compared to the standard FFS for nasal intubation in such patients. Methods: After the ethical committee approval, we included 54 oropharyngeal cancer patients divided randomly into two equal groups: Group G and Group F. After pre-medication and pre-oxygenation, awake nasal intubation was performed using GL in Group G and FFS in Group F. In both groups, we compared intubation time in seconds (mean ± standard deviation) (primary outcome), success rate of the first intubation attempt, percentage of Cormack and Lehane glottic score and incidence of complications. We assumed that GL could be a suitable alternative for the standard FFS in nasal intubation of patients with oropharyngeal cancer. Success rate of the first attempt and Cormack and Lehane glottic score were compared using Chi-square test. Results: Intubation time in seconds was significantly shorter in Group G (70.85 ± 8.88 S) than in Group F (90.26 ± 9.41 S) with (P < 0.001). The success rate of the first attempt intubation was slightly higher in Group G (81.5%) than Group F (78.8%). Cormack and Lehane glottic Score I and II showed insignificant difference between both Group G (92.6%) and Group F (96.3%). We detected three cases of sore throat in each group. Conclusion: GlideScope® could be a suitable alternative to FFS in nasal intubation of oropharyngeal cancer patients.
Transmettre des valeurs entre générations : tel père tel fils ?

Ce texte propose un historique des differentes etudes concernant le degre de mobilite intergenerationnelle des patrimoines. L’ensemble des mesures etablies par les differents auteurs permet de juger de l’importance de la transmission des inegalites de richesse selon les societes. Outre les transferts intergenerationnels materiels (heritage et donations), certaines etudes prennent en compte la transmission d’autres caracteristiques : education, revenus, preferences, genes, . , pour expliquer le degre de mobilite.La plupart des etudes econometriques sur la mobilite intergenerationnelle des patrimoines met en evidence un effet non negligeable de la fortune des parents pour expliquer celle de leur progeniture. L’ampleur de cette immobilite depend des pays, des epoques, des donnees utilisees, mais aussi des niveaux de richesse eux-memes. L’elasticite intergenerationnelle du patrimoine est sans doute plus elevee chez les riches (autour de 0,70) que dans le reste de la population ou elle depasse rarement 0,50 : autrement dit, avoir des parents deux fois plus dotes que la moyenne de leur generation permet au maximum d’etre plus fortune de 50 % par rapport a la sienne.
Integrating the Kano Model into Designing Service Quality of Online-Shopping Web to Enhance Customer Satisfaction

The customer satisfaction is one of important factors for service performance of online shopping web. The Kano model is used to better understand the relationship between performance criteria and customer satisfaction, and to resolve trade-off dilemma in multiple-criteria optimization by identifying the key criteria in customer satisfaction. This study presents an approach incorporating the Kano model to obtain the optimal combination of service quality elements for online shopping webs. On the basis of the study of the service quality of e-commerce, this study identifies 23 factors of service quality which impact of customer satisfaction of online shopping, then Carries out a customer satisfaction survey on online shopping, 173 valid questionnaires recovered. Based on Kano model analysis, the service quality elements can be divided into three categories that are the basic factor quality, performance quality, and attractive quality. Keywords-service quality; kano model; e-service; customer satisfaction
Factors associated with readmission to adolescent psychiatric care.

OBJECTIVE The aim of this study is to identify factors associated with readmission to adolescent psychiatric inpatient care, in the context of a relapsing major mental illness. METHOD Data were obtained from 71 patients admitted to an adolescent psychiatric inpatient unit over a 2-year period. Patients who were rehospitalized within 12 months of discharge were compared with patients who had only one admission during the study period with respect to diagnosis, age of first admission, history of child sexual abuse (CSA) and the events precipitating admission. RESULTS Medication non-adherence and a history of CSA were positively and independently associated with relapse readmission, while a trend emerged among readmitted patients toward younger age at first psychiatric hospitalization. A negative association was found between readmission and the experience of personal loss. Readmission was not related to DSM-IV axis I or axis II diagnosis, including substance abuse. CONCLUSIONS The association, in an adolescent sample, of medication non-adherence and relapse readmission is consistent with findings from numerous adult studies, as is the trend toward younger age of first admission. The relationship of a history of CSA to readmission has attracted little previous research and the finding of a positive association suggests that further investigation of a history of CSA in this context is warranted. The implications of these findings and suggestions for further research are discussed.
Cointegrating Analysis of Monetary Transmission Mechanism

In this paper, the mechanism is investigated by which mone同rypolicy is transmitted to the real economy in Japan. The stationarity of variables is checked by unit root test and the cointegTation property a.mong nonstationary variables is tested by Johansen、method.The system is cons七ructedin a form of VEClVI(Vector Error Corr巴ctionlVIodel) and finaly impulse responses of real GDP are calculated under several situations where the shock of cal 1 rate influences to real GDP with two channels of money and credit.
Patient predictors of response to psychotherapy and pharmacotherapy: findings in the NIMH Treatment of Depression Collaborative Research Program.

OBJECTIVE The authors investigated patient characteristics predictive of treatment response in the National Institute of Mental Health (NIMH) Treatment of Depression Collaborative Research Program. METHOD Two hundred thirty-nine outpatients with major depressive disorder according to the Research Diagnostic Criteria entered a 16-week multicenter clinical trial and were randomly assigned to interpersonal psychotherapy, cognitive-behavior therapy, imipramine with clinical management, or placebo with clinical management. Pretreatment sociodemographic features, diagnosis, course of illness, function, personality, and symptoms were studied to identify patient predictors of depression severity (measured with the Hamilton Rating Scale for Depression) and complete response (measured with the Hamilton scale and the Beck Depression Inventory). RESULTS One hundred sixty-two patients completed the entire 16-week trial. Six patient characteristics, in addition to depression severity previously reported, predicted outcome across all treatments: social dysfunction, cognitive dysfunction, expectation of improvement, endogenous depression, double depression, and duration of current episode. Significant patient predictors of differential treatment outcome were identified. 1) Low social dysfunction predicted superior response to interpersonal psychotherapy. 2) Low cognitive dysfunction predicted superior response to cognitive-behavior therapy and to imipramine. 3) High work dysfunction predicted superior response to imipramine. 4) High depression severity and impairment of function predicted superior response to imipramine and to interpersonal psychotherapy. CONCLUSIONS The results demonstrate the relevance of patient characteristics, including social, cognitive, and work function, for prediction of the outcome of major depressive disorder. They provide indirect evidence of treatment specificity by identifying characteristics responsive to different modalities, which may be of value in the selection of patients for alternative treatments.
Comparison of Isoflurane and Desflurane Anesthetic Depth Using Burst Suppression of the Electroencephalogram in Neurosurgical Patients

We compared the anesthetic effects of desflurane and isoflurane using percent burst suppression of the electroencephalogram (EEG) as an end-point in 10 neurosurgical patients. The EEG was recorded from frontal leads and processed variables were analyzed as a function of increasing isoflurane and desflurane concentration with age and baseline delta EEG power (0.5-3.75 Hz) as independent variables. Isoflurane and desflurane (0.5, 1.0, 1.5, 2.0 minimum alveolar anesthetic concentration [MAC]) were incrementally administered until the EEG was quiesecent at least 40% of the time. Both anesthetics were evaluated separately in each patient. By analysis of variance, isoflurane and desflurane produced doserelated increments in burst suppression which were significantly affected by the age and baseline delta EEG of the patient. When isoflurane and desflurane were equated by MAC and adjusted for age, they produced statistically similar patterns of EEG burst suppression. Within subjects, a high degree of correlation was observed for percent burst suppression between equipotent levels of isoflurane and desflurane (r = 0.85; P < 0.05). Patients with baseline delta EEG power less than 80% of total power showed increases in delta EEG and decreases in median frequency with isoflurane and desflurane. Patients with baseline delta EEG power > 80% of total power produced no change in EEG frequency with increasing anesthesia but revealed a greater sensitivity to the development of burst suppression. These results show that isoflurane and desflurane produce similar EEG suppression in neurosurgical patients. If the EEG is initially slow, further slowing cannot be used to assess anesthetic depth. (Anesth Analg 1995;81:811-6)
Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.

A series of selective antiherpetic compounds were found to exert pronounced cytostatic activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) thymidine kinase (TK) gene-transfected mammary carcinoma FM3A cells. Based on their potency and mechanism of cytostatic action, the antiherpetic compounds could be divided into two different classes. The first class encompasses (E)-5-(2-bromovinyl)-2'-deoxyuridine and structurally related analogues thereof [i.e., the cytosine derivative (E)-5-(2-bromovinyl)-2'-deoxycytidine and the 4'-thio derivative (E)-5-(2-bromovinyl)-2'-deoxy-4'-thiouridine]. These compounds are exquisitely cytostatic against FM3A/TK-/HSV-1 TK+ and FM3A/TK-/HSV-2 TK+ cells (50% inhibitory concentrations ranging from 0.047 to 0.001 microM) and inhibit tumor cell proliferation by inhibiting cellular thymidylate synthase. The second class consists of the acyclic guanosine derivatives penciclovir, buciclovir, and ganciclovir. These compounds are also more inhibitory to the HSV-1 TK or HSV-2 TK gene-transfected FM3A cells than to FM3A/0 or FM3A/TK- cells, but at concentrations that are higher than the concentrations at which the (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives proved to be inhibitory. These acyclic guanosine analogues appear to be targeted at the cellular DNA polymerase. From this study, (E)-5-(2-bromovinyl)-2'-deoxy-4'-thiouridine emerged as a promising candidate compound for the treatment of HSV-1 TK gene-transfected tumors in vivo, due to its metabolic stability (i.e., resistance to hydrolysis by thymidine phosphorylase).
Essays in Financial Econometrics

The first paper sheds light on the informational content of high frequency data and daily data. I assess the economic value of the two family models comparing their performance in forecasting asset volatility through the Value at Risk metric. In running the comparison this paper introduces two key assumptions: jumps in prices and leverage effect in volatility dynamics. Findings suggest that high frequency data models do not exhibit a superior performance over daily data models. In the second paper, building on Majewski et al. (2015), I propose an affine-discrete time model, labeled VARG-J, which is characterized by a multifactor volatility specification. In the VARG-J model volatility experiences periods of extreme movements through a jump factor modeled as an Autoregressive Gamma Zero process. The estimation under historical measure is done by quasi-maximum likelihood and the Extended Kalman Filter. This strategy allows to filter out both volatility factors introducing a measurement equation that relates the Realized Volatility to latent volatility. The risk premia parameters are calibrated using call options written on S&P500 Index. The results clearly illustrate the important contribution of the jump factor in the pricing performance of options and the economic significance of the volatility jump risk premia. In the third paper, I analyze whether there is empirical evidence of contagion at the bank level, measuring the direction and the size of contagion transmission between European markets. In order to understand and quantify the contagion transmission on banking market, I estimate the econometric model by Ait-Sahalia et al. (2015) in which contagion is defined as the within and between countries transmission of shocks and asset returns are directly modeled as a Hawkes jump diffusion process. The empirical analysis indicates that there is a clear evidence of contagion from Greece to European countries as well as self-contagion in all countries.
Transfer of Plasma Lipoprotein Components and of Plasma Proteins into Aortas of Cholesterol‐Fed Rabbits

The arterial influx of esterified and free cholesterol from low density Iipoproteins and very low density Iipoproteins in 20 hyperchoiesteroiemic rabbits was measured simultaneously by the use of Iipoproteins labeled in vivo with [3H]- and [14C]-cholesterol. The simultaneous arterial influx of either [3H]-leucine-labeled very low density Iipoproteins, low density Iipoproteins, high density Iipoproteins, or plasma proteins was also measured in each rabbit. The arterial influx was calculated as intimai clearance, i.e., the influx of a given fraction divided by its plasma concentration. The intimai clearance of low density lipoprotein esterified cholesterol was equal to that for the apolipoproteins of that fraction, which is compatible with an arterial influx of intact low density lipoprotein molecules. The intimai clearance of very low density apolipoprotein or cholesteryl ester was less than that for low density lipoprotein, whereas high density lipoprotein and albumin clearances exceeded low density lipoprotein clearance by 1.5-to 3-fold. The intimai clearances of plasma proteins, high density, low density, and very low density Iipoproteins decreased linearly with the logarithm of the macromolecular diameter. This indicates that the arterial influx of three plasma lipoprotein fractions and of plasma proteins proceeds by similar mechanisms. Apparently the relative intimai clearances of Iipoproteins are more dependent on their size relative to pores or vesicular diameters at the plasma-artery interface than on specific interactions between Iipoproteins and the arterial intimai surface.
Involvement of dimethylarginine dimethylaminohydrolase‐2 in visfatin‐enhanced angiogenic function of endothelial cells

Visfatin, a new adipocytokine, was reported to promote angiogenesis. Dimethylarginine dimethylaminohydrolase (DDAH), which could regulate vascular endothelial growth factor (VEGF) expression in endothelial cells, is thought as a novel modulator of angiogenesis. The aim of the study was to investigate the role of DDAH2 in visfatin‐induced angiogenesis in human umbilical vein endothelial cells (HUVECs).
Aligning the Social Interaction Spaces of Intergenerational Family Members

The adoption of digital media for supporting social interaction among family members has caused a misalignment between the social interaction spaces of different generations. This usually produces social isolation in the elderly people due to their limitations on using digital media. This thesis work studies cross-generational family communication practices, in order to provide insights for designing computer-mediated solutions that help reduce the social isolation of elderly people. Based on that, we intend to support family connection through a social personalization model that tries to align the social interaction spaces of the elderly with those of their family members.
Linkage mapping of a novel susceptibility locus for Behçet's disease to chromosome 6p22-23.

OBJECTIVE The etiology of Behçet's disease is unknown; however, familial aggregation studies indicate a strong genetic background and a complex inheritance model. Association of HLA-B51 with Behçet's disease is regarded as being the strongest evidence of genetic contribution described to date. A low rate of recombination was observed within the telomeric end of the major histocompatibility complex up to the HFE gene, which causes hereditary hemochromatosis. We therefore hypothesized that the telomere of 6p may harbor a susceptibility gene for Behçet's disease. METHODS A series of 28 multicase families of Turkish origin was ascertained, and 78 of the 183 available family members were diagnosed as having Behçet's disease. For the analysis of the telomeric region adjacent to HLA-B, we used a panel of 20 highly polymorphic microsatellite markers between D6S273 and D6S470, covering a region of approximately 36 cM. RESULTS Multipoint nonparametric linkage analysis using GeneHunter 2.0 software revealed a broad peak of linkage, with the highest Z score of 4.11 at position D6S285, which is approximately 17 cM telomeric to HLA-B. CONCLUSION This significant linkage finding may indicate a second susceptibility locus in the telomere of chromosome 6p. Identification of this putative susceptibility gene could help to further understand the pathogenesis of Behçet's disease.
Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity

Significance Basal ganglia circuits are engaged in controlling psychomotor function. The circuits consist of striatonigral and striatopallidal pathways. The opposing but balanced activity of these two neural pathways is important for regulating movement-related functions. How the cell types of striatonigral and striatopallidal neurons are specified to construct these two pathways during development remains elusive. We found that the LIM homeodomain transcription factor Islet-1 (Isl1) was specifically expressed in striatonigral neurons during development. Genetic inactivation of Isl1 resulted in increased apoptosis, abnormal differentiation, and aberrant axonal projections of striatonigral neurons. These findings suggest that Isl1 plays a key role in specification of striatonigral neurons. Our study provides insights into genetic mechanisms by which basal ganglia circuits are built to function. Striatal projection neurons comprise two populations of striatonigral and striatopallidal neurons. These two neuronal populations play distinct roles in controlling movement-related functions in the basal ganglia circuits. An important issue is how striatal progenitors are developmentally specified into these two distinct neuronal populations. In the present study, we characterized the function of Islet-1 (Isl1), a LIM-homeodomain transcription factor, in striatal development. Genetic fate mapping showed that Isl1+ progeny specifically developed into a subpopulation of striatonigral neurons that transiently expressed Isl1. In Nestin-Cre;Isl1f/f KO mouse brain, differentiation of striatonigral neurons was defective, as evidenced by decreased expression of striatonigral-enriched genes, including substance P, prodynorphin, solute carrier family 35, member D3 (Slc35d3), and PlexinD1. Striatonigral axonal projections were also impaired, and abnormal apoptosis was observed in Isl1 KO striatum. It was of particular interest that striatopallidal-enriched genes, including dopamine D2 receptor (Drd2), proenkephalin, A2A adenosine receptor (A2aR) and G protein-coupled receptor 6 (Gpr6), were concomitantly up-regulated in Isl1 mutant striatum, suggesting derepression of striatopallidal genes in striatonigral neurons in the absence of Isl1. The suppression of striatopallidal genes by Isl1 was further examined by overexpression of Isl1 in the striatum of Drd2-EGFP transgenic mice using in utero electroporation. Ectopic Isl1 expression was sufficient to repress Drd2-EGFP signals in striatopallidal neurons. Taken together, our study suggests that Isl1 specifies the cell fate of striatonigral neurons not only by orchestrating survival, differentiation, and axonal projections of striatonigral neurons but also by suppressing striatopallidal-enriched genes. The dual action of developmental control by Isl1 in promoting appropriate striatonigral but repressing inappropriate striatopallidal genetic profiles may ensure sharpening of the striatonigral identity during development.
Developmental Enamel Defects in Primary Teeth in Children with Cerebral Palsy, Mental Retardation, or Hearing Defects: A Review

Developmental enamel defects in primary teeth have been found at least twice as frequently in children with cerebral palsy or mental retardation as in control children, and frequently also in children with sensori-neural hearing deficits. The developing tooth germ is sensitive to a range of systemic disturbances, some of which may also affect neurologic development. Because the enamel cannot recover once it is damaged, it may provide a repository of information on the timing and nature of insults potentially affecting other ectodermally derived structures, including the brain. This paper reviews the literature on developmental defects of enamel in primary teeth, asking whether these might be useful as biological markers of the timing and in some cases the nature of insults. Among systemic factors related to development of enamel that might also have implications for neurologic development are certain genetic disorders including tuberous sclerosis, premature birth, neonatal nutritional disturbances (especially hypocalcemia), viral infections (such as rubella and cytomegalovirus during gestation), thyroid disorders, and maternal diabetes. It is concluded that further research is warranted concerning whether developmental defects of dental enamel can be useful markers for the timing of intra-uterine or perinatal events associated with certain neurologic and sensory disorders of children.