Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification, characterization, and synthesis of process-related impurities in antiproliferative agent TQ-B3203

ABSTRACT Liposoluble camptothecin derivative, research name TQ-B3203, is a recently developed investigational antiproliferative agent by our group. The structure of TQ-B3203 is 2-(hexadecyloxycarbonyl)-2,5,7,8-tetramethylchroman-6-yl 7-ethyl-camptothecin-10-yl succinate, containing an SN-38 component, a trolox component, a succinic acid linker, and a hexadecanol chain. In this study, the process-related impurities of bulk TQ-B3203 were identified, characterized, and synthesized. Seven major impurities were revealed based on the mass spectrum (MS) and nuclear magnetic resonance (NMR) spectral data. They were characterized as SN-38 (IMP-I), trolox (IMP-II), 2-(dodecyloxycarbonyl)-2,5,7,8-tetramethylchroman-6-yl 7-ethyl-camptothecin-10-yl succinate (IMP-III), hexadecyl 7-ethyl-camptothecin-10-yl succinate (IMP-IV), 2-(tetradecyloxycarbonyl)-2,5,7,8-tetramethylchroman-6-yl 7-ethyl-camptothecin-10-yl succinate (IMP-V), 4-(2-(hexadecyloxycarbonyl)-2,5,7,8-tetramethylchroman-6-yloxy)-4-oxobutanoic acid (IMP-VI), and 4-(2-(octodecyloxycarbonyl)-2,5,7,8-tetramethylchroman-6-yloxy)-4-oxobutanoic acid (IMP-VII). The probable origin of the impurities from the preparation process of TQ-B3203 was discussed. GRAPHICAL ABSTRACT
Technique for Reconstruction of Nasal Alar Defects in Asian Patients with a Modified Bilobed Nasolabial Flap

Introduction: The Oriental nose differs from the Caucasian nose in terms of size, subunit definition, texture, and thickness of the skin [1]. Zitelli’s bilobed flap enables aesthetic reconstruction in Caucasian noses but in smaller Oriental noses the outcomes are less desirable with nasal alar retraction commonly seen [2]. Hence, we describe a modification of Zitelli’s bilobed flap incorporating nasolabial skin for a single stage nasal reconstruction with reduced nasal alar retraction [3]. Methods: We modified the bilobed flap based on Zitelli’s bilobed flap and the aesthetic subunit principle, as modified for Orientals by Yotsuyanagi in 2000 [4]. The primary lobe was located between the defect and the cheek and the second lobe was located on the cheek, above the nasolabial fold. The modification of the bilobed flap was designed to have a primary lobe that was 10% longer than the length of the distal defect edge from the flap’s pivot point, and the width of the primary lobe was equal to the width of the defect. The length of the secondary lobe was 130% of the length of the distal defect edge to the flap’s pivot point, and the width of the secondary lobe was two-thirds the width of the primary lobe. Results: Satisfactory alar reconstruction was achieved from the viewpoint of the patient and surgeon. There was good nasal contour and appropriate symmetry of the nasal tip with reduced nasal alar retraction. Conclusion: The modification of Zitelli’s bilobed flap to have a longer primary lobe and include nasolabial skin, results in reduced nasal alar retraction.
Effects of Core Stability Exercises, Lumbar Lordosis and Low-Back Pain: A Systematic Review

Core stability has a very positive effect on the prevention of lumbar lordosis and lower back pain. The main focus of this paper was on a review of the available literature on the influence of trunk stability on lower back pain and lumbar lordosis. The two electronic databases researched for collecting articles are PubMed and ScienceDirect. A search was conducted by title, taking a predefined combination of the following keywords into account: low back pain, core stability, training, sports. Screening processes are summarized through a PRISMA flow chart. 408 studies were identified, of which 20 met the inclusion criteria. It was concluded that exercise on the stability of the pelvic nucleus and muscles is recommended as the simplest and most favorable prevention of lower back pain and lumbar lordosis. The stability of the nucleus helps to overcome the main causes and deprive the body of functional disorders and pain.
The use of Ventilator Parameters in the Prediction of Development and Outcome of Acute Respiratory Distress Syndrome in Postoperative Patients

Background: To investigate the usefulness of ventilator parameters in the prediction of development and outcome of acute respiratory distress syndrome (ARDS) in postoperative patients with esophageal or lung cancer on admission to the surgical intensive care unit (SICU). Methods: A total of 32 post-operative patients with lung or esophageal cancer from SICU in a tertiary medical center were retrospectively analyzed. The study patients was divided into ARDS group (n = 21) and non-ARDS group (n = 11). ARDS group were the post-operative patients who developed ARDS after lung or esophageal cancer surgery. The ventilator variables were analyzed in this study. Principal component analysis (PCA) was performed to reduce the correlated ventilator variables to a small set of variables. By using the PCA selection method, top three ventilator variables with large coefficients can be considered as sensitive variables and were included in the analysis model based on the rule of 10 events per variable. Firth logistic regression with selective stepwise elimination procedure was performed to identify the most important predictors of morbidity and mortality in patients with ARDS. The ventilator parameters including rapid shallow breath index during mechanical ventilation (RSBIv), rate pressure product of ventilation (RPPv), rate pressure volume index (RPVI), mechanical work (MW), and inspiration to expiration time ratio (IER) were analyzed in this studyResults: The newly defined parameter MW/IER was the most important predictors for the development of ARDS, and both RPPv and RPVI were the significant predictors of mortality in patients with ARDS.Conclusion: Some ventilator parameters can be derived from ventilator readings and be used to predict the development and outcome of ARDS in mechanically ventilated patients on admission to the SICU, such as RPPv, RPVI and MW/IER defined in this study.
Assessment of Cerebellar and Hippocampal Morphology and Biochemical Parameters in the Compound Heterozygous, Tottering/leaner Mouse

Assessment of Cerebellar and Hippocampal Morphology and Biochemical Parameters in the Compound Heterozygous, Tottering/leaner Mouse. (December 2009) Emily Mary Murawski, B.S., Texas A&M University Chair of Advisory Committee: Dr. Louise C. Abbott Due to two different mutations in the gene that encodes the α1A subunit of voltage-activated CaV 2.1 calcium ion channels, the compound heterozygous tottering/leaner (tg/tg la ) mouse exhibits numerous neurological deficits. Human disorders that arise from mutations in this voltage dependent calcium channel are familial hemiplegic migraine, episodic ataxia-2, and spinocerebellar ataxia 6. The tg/tg la mouse exhibits ataxia, movement disorders and memory impairment, suggesting that both the cerebellum and hippocampus are affected. To gain greater understanding of the many neurological abnormalities that are exhibited by the 90-120 day old tg/tg la mouse the following aspects were investigated: 1) the morphology of the cerebellum and hippocampus, 2) proliferation and death in cells of the hippocampal dentate gyrus and 3) changes in basic biochemical parameters in granule cells of the cerebellum and hippocampus. This study revealed no volume abnormalities within the hippocampus of the mutant mice, but a decrease in cell density with the pyramidal layer of CA3 and the hilus of the dentate gyrus. Cell size in the CA3 region was unaffected, but cell size in the
Detection of HMA5, PCs and MT2 Genes Expression in Vicia faba Under Heavy Metal Stress Using Quantitative Real-Time PCR

In order to achieve phytoremediation during agricultural production, it is essential to identify high genotypesyield that is able of accumulating many types of heavy metals not in the edible parts which have significantnutritional value but in the non-edible parts. This study conducted to estimate the heavy metal ATPases 5(HMA5), Phytochelatins synthase (PCs) and metallothionein 2 (MT2) genes expression in plant Vicia fabain response to an elevated concentration of copper and zinc in nutrient media. Using Quantitative RealTime PCR (RT-qPCR) technique, the results of hydroponic culture methods with high concentrations ofcopper (75 µMol / L) and high concentration of zinc (500 µ Mol / L) showed high expression level for thethree genes of Vicia faba plant compared with control. Established that the expression of the genes underthe influence of copper ion was higher than the expression under zinc ion influence. Besides that, geneexpression increased with increased exposure time to zinc ion, also in the case of copper ion exposure time,all genes expression slightly increases with increased exposure time. In response to excess copper and zinc,an increase in the expression of genes (HMA5, PCs and MT2) involved in plant protection, providing thepossibility of its transfer from the cytosol to the apoplast demonstrate that this plant might be useful forphytoremediation of moderately polluted areas with copper or zinc.
Recreational watercraft decontamination: can current recommendations reduce aquatic invasive species spread?

Decontaminating recreational watercraft, and fishing, sailing or watersports equipment after use can reduce the overland dispersal of aquatic invasive species (AIS) among lakes. Recommended methods include pressure-washing, rinsing with hot water, using cleaning agents, or air-drying, but the extent of their efficacy is unknown. The aim of this review is to assess the effectiveness of current decontamination measures for recreational watercraft against various AIS. Web of Science, Greenfile, Environment Complete and Geobase were searched for articles published through September 2019. Studies on preventing overland AIS spread, and plant and invertebrate AIS response to hot water, pressure-washing, desiccation or cleaning agents, were selected. Of 37 studies included in the review, the majority (70.3%) assessed air-drying, followed by hot water (32.4%), household chemicals (16.2%), and pressure-washing (2.7%). The recommended air-drying duration of up to one week produced high mortality (≥ 90%) a mong several invertebrate and macrophyte species, although survival was high for certain aquatic snails. Larger and/or older invertebrates were more resistant to desiccation. Aquatic plant survival and growth were inversely related to water loss (a function of drying time and relative humidity), and short or single fragments were less resistant to air-drying than larger or clustered fragments. Immersion in water ≥ 50 °C for 15 minutes resulted in 100% mortality among mussels, small invertebrates and some plant species. A higher temperature of 60 °C was required for hot water spray applications lasting ≥ 5 seconds to achieve the same mortality rate among dreissenid mussels. High pressure-washing eliminated significantly more entangled plants, and small organisms and seeds than low pressure. Household chemicals such as salt or bleach required specific doses and immersion durations to be lethal to small organisms. This review reveals that current decontamination methods may be effective, but their efficacy against a diversity of AIS, including those on watch lists, are not yet well-understood. As the literature is currently skewed towards studies on air-drying, which has limited efficacy, further research is required to evaluate practical, and alternate or combined measures to best inform management practices.
Radio Frequency Fingerprinting on the Edge

Deep learning methods have been very successful at radio frequency fingerprinting tasks, predicting the identity of transmitting devices with high accuracy. We study radio frequency fingerprinting deployments at resource-constrained edge devices. We use structured pruning to jointly train and sparsify neural networks tailored to edge hardware implementations. We compress convolutional layers by a <inline-formula><tex-math notation="LaTeX">$27.2\times$</tex-math><alternatives><mml:math><mml:mrow><mml:mn>27</mml:mn><mml:mo>. </mml:mo><mml:mn>2</mml:mn><mml:mo>×</mml:mo></mml:mrow></mml:math><inline-graphic xlink:href="jian-ieq1-3064466.gif"/></alternatives></inline-formula> factor while incurring a negligible prediction accuracy decrease (less than 1 percent). We demonstrate the efficacy of our approach over multiple edge hardware platforms, including a Samsung Gallaxy S10 phone and a Xilinx-ZCU104 FPGA. Our method yields significant inference speedups, <inline-formula><tex-math notation="LaTeX">$11.5\times$</tex-math><alternatives><mml:math><mml:mrow><mml:mn>11</mml:mn><mml:mo>. </mml:mo><mml:mn>5</mml:mn><mml:mo>×</mml:mo></mml:mrow></mml:math><inline-graphic xlink:href="jian-ieq2-3064466.gif"/></alternatives></inline-formula> on the FPGA and <inline-formula><tex-math notation="LaTeX">$3\times$</tex-math><alternatives><mml:math><mml:mrow><mml:mn>3</mml:mn><mml:mo>×</mml:mo></mml:mrow></mml:math><inline-graphic xlink:href="jian-ieq3-3064466.gif"/></alternatives></inline-formula> on the smartphone, as well as high efficiency: the FPGA processing time is <inline-formula><tex-math notation="LaTeX">$17\times$</tex-math><alternatives><mml:math><mml:mrow><mml:mn>17</mml:mn><mml:mo>×</mml:mo></mml:mrow></mml:math><inline-graphic xlink:href="jian-ieq4-3064466.gif"/></alternatives></inline-formula> smaller than in a V100 GPU. To the best of our knowledge, we are the first to explore the possibility of compressing networks for radio frequency fingerprinting; as such, our experiments can be seen as a means of characterizing the informational capacity associated with this specific learning task.
Design of a Wide-Input-Voltage PCB-Embedded Transformer Based Active-Clamp Flyback Converter Considering Permeability Degradation

Today, high power density, high efficiency, and wide-input-voltage operation are becoming increasingly important in power electronics for automotive applications. Active-clamp flyback (ACF) converters, showing a good tradeoff between simplicity and efficiency, are widely used in this industry. With benefits of small profile, low cost, and high reliability in mass production, the printed-circuit-board (PCB) embedding technique of magnetic components has attracted strong interest; however, magnetic cores can lose significant permeability due to the mechanical stress during this fabrication process; as a result, transformer properties, such as leakage inductance, coupling coefficient, and effective turns ratio change, affecting the input-voltage operating range as well as the working temperature. In this article, a detailed analysis of the design constraints of automotive ACF converters with a wide-input-voltage requirement is presented, focusing on the impact that the embedding process has on the transformer properties and the converter operation. Specifically, experiments are performed to investigate the permeability degradation effect, based on which correction factors are derived and added to the proposed design optimization process. A 10-W dual-output high power density (53.2 W/in3) integrated ACF converter prototype based on GaN devices operating at 1 MHz is built and demonstrated for this purpose.
Application Research On Satisfaction Evaluation Of Clothing Advertising Based On Micro Expression Recognition Technology

---------------------------------------------------------------------- ABSTRACT ----------------------------------------------------------- Questionnaire is one of the most important means to collect data and make information decision. In this paper, the micro expression recognition technology of artificial intelligence is applied in the field of print advertising satisfaction collection and information decision-making. Starting with the analysis of micro expression, a new concept of satisfaction factor of print advertising is proposed and then various optimization functions in neural network are analyzed and discussed. In the following part, the Adabound optimization function is applied to the network model in the example of clothing print advertisement and the convergence speed of the loss function is accelerated in order to improve the detection accuracy of the model. Experimental result shows the satisfaction of the viewers to the clothing print advertisements, allowing researchers to judge their purchase desire at the same time.
Decreased levels of vaspin and its potential association with cardiometabolic risk in patients with psoriasis: preliminary results

Introduction Omentin and vaspin are considered to have beneficial effects preventing the development of metabolic disorders which are common comorbidities in psoriasis. Aim To evaluate the serum level of these adipokines in psoriatic patients and elucidate possible associations with disease activity, metabolic or inflammatory parameters and systemic treatment. Material and methods Thirty-three patients with active plaque-type psoriasis and 11 healthy controls participated in the study. Blood samples were collected before and after 3 months of treatment with acitretin or methotrexate. Results Serum vaspin concentration in psoriatic patients was significantly lower than in the control group (p < 0.05). No correlation between adipokines and severity of disease evaluated with PASI was found. However, median vaspin levels decreased with the severity of skin lesions and the omentin level was higher in patients with severe disease versus those with moderate form (p < 0.05). The vaspin level correlated with BMI of psoriatic patients (p < 0.05), with cholesterol and triglycerides levels (p = 0.054, p = 0.049, respectively). No significant effect of systemic treatment on omentin levels was found. Regarding vaspin, we observed an upward trend in its concentration after treatment. Conclusions Omentin and vaspin may play a modulating role in the systemic inflammation present in psoriasis and thus may contribute to the development of metabolic complications.
Functional Connectivity in Multi-Habitat Marine Species

Many marine species use different habitats at different stages of their life cycle. Functional connectivity, the degree to which the seascape facilitates or impedes movement between habitat patches, is poorly studied in marine systems. We reviewed the scientific literature to explore the various barriers preventing functional connectivity between marine habitats and how the removal of these barriers may restore connectivity. To our knowledge, this is the first systematic review to investigate functional connectivity between life cycle habitats for a range of marine species. A total of 4,499 records were identified and screened, leaving 69 publications eligible for review. The results highlighted a range of distances between nursery and adult habitats that limited functional connectivity for a number of species, predominantly reef fishes. For some species, adults were absent on reefs >9km from the closest nursery habitat, suggesting a threshold for connectivity. Similarly, increased distance between spawning and settlement habitats decreased settling success of larvae of various taxa. Pelagic larval duration, seascape topography and climate change were also shown to impact functional connectivity during the larval phase. The removal and mitigation of barriers preventing functional connectivity, including dams and habitat fragmentation, restored connectivity between disconnected life cycle habitats, but the efficacy of these approaches differed between species and studies. The results of this review deepen our understanding of marine functional connectivity between life cycle habitats via larval, juvenile, and adult dispersal. These findings have implications for the design and management of marine reserve networks.
A langasite surface acoustic wave wide-range temperature sensor with excellent linearity and high sensitivity

Langasite (LGS) surface acoustic wave (SAW) temperature sensors have a large second order temperature coefficient of frequency, which leads to their non-linear and non-monotonic responses in a wide temperature range and possibly makes the measured temperatures non-unique for a specific sensor response. Here, we propose a high-temperature Pt/LGS SAW sensor with linear frequency–temperature behavior in a wide temperature range, which was fabricated on a LGS (0°, 138.5°, 72°) substrate. The sensor has a single acoustic mode, but dual resonances with similar second- and third-order temperature sensitivities that were utilized for achieving a linear frequency–temperature response by a method of difference. A linear relationship between the measured sensor output (Δfm21) and temperature was obtained in the range of −60 °C to 700 °C, consistent with the theoretical analysis. The sensor has a high sensitivity of −167 ppm/K for the whole temperature range. All the results demonstrated exciting prospects of the sensor for wide temperature monitoring in harsh environments.
Network in Sequential Form: Combine Tree Structure Components into Recurrent Neural Network

Smaller units nestled in larger units-a natural language that is hierarchically ordered. Smaller sections are replaced because of the completion of the bigger constituencies. The basic LSTM architecture does not have a clear choice for modeling the hierarchy of components as separate neurons do not require knowledge to be monitored on various time scales. The idea in this paper is to introduce inductive bias by grouping the neurons. The modifications we create to the master input vector are changed in all neurons following the order of the specified neuron and forget windows. Four activities on which we can achieve strong care unattended sorting, logical inference, and language modeling and guided syntax evaluation.
3-D Textural Analysis of 2-[¹⁸F]FDG PET and Ki67 Expression in Nonsmall Cell Lung Cancer

The immunohistochemical determination of the Ki67 expression is regarded as a reliable method to monitor nonsmall cell lung cancer (NSCLC) proliferation. However, cancer tissues are not uniform and the use of a small tumor sample in biopsy may not be accurate. Although positron emission tomography (PET) represents an alternative to biopsy, by providing the 3-D functional and morphological distribution of cancer cells across the entire tumor volume, standardized uptake values (SUVs) exhibit poor accuracy. The purpose of this study is to identify quantitative features in 2-[18F]FDG PET images uniquely correlated with proliferating lung cancer cells that may perform better than SUVs in the evaluation of lung cancer proliferation. By using a xenograft NSCLC model implanted in 19 mice, we found that 89 textural parameters extracted from 3-D 2-[18F]FDG uptake can be described by 6 independent principal components accounting for 95% of the total variance. One of these components features a significant and univocal correlation with 3-D-stacked Ki67 staining immunohistochemical images ( $|r|>0.6; P< 0.05/6$ , including compensation for multiple comparisons). Furthermore, the values of these components extracted from the PET images of in vivo and ex vivo explanted NSCLC cancers exhibit a strong correlation, verifying the stability of the segmentation method.