Miracle-dz/UniFAR-FTUs huggingface dataset:
Targeted-mitochondria antioxidants therapeutic implications in inflammatory bowel disease

Abstract The role of the mitochondria, particularly its implications in cellular redox and oxidative balance is important for cell survival, and is involved in a variety of human diseases including inflammatory bowel disease (IBD). In this review we address mitochondria physiology and reactive oxygen species as cognate to IBD. Several studies have reported altered mitochondria function in intestinal epithelium in IBD. However, mitochondrion significance in this disease has not been much investigated. Finally, we suggest potential for antioxidants targeted to mitochondria in IBD therapy as a treatment strategy.
Robust impulsive synchronization of uncertain dynamical networks

This paper studies robust impulsive synchronization of uncertain dynamical networks. By utilizing the concept of impulsive control and the stability results for impulsive systems, several criteria for robust local and robust global impulsive synchronization are established for complex dynamical networks, in which the network coupling functions are unknown but bounded. Three examples are also worked through for illustrating the main results.
Optimisation du protocole de recherche des Escherichia coli producteurs de Shiga-toxines (STEC) dans les aliments

Les Escherichia coli producteurs de Shiga-toxines (STEC) sont des agents pathogenes importants emergents en sante publique. Ces bacteries sont a l’origine des epidemies de colites hemorragiques et de syndrome hemolytique et uremique (SHU). La grande majorite des cas est liee a la consommation d’aliments contamines par un type particulier de STEC appeles E. coli enterohemorragiques (EHEC) parmi lesquels on trouve les serogroupes definis comme pathogenes par l’AFSSA : O26, O103, O111, O145 et O157.Les bovins ont depuis longtemps ete identifies comme un important reservoir de STEC. Bien que la transmission des STEC a l'homme soit frequemment associee a la consommation de viande, les produits laitiers ont egalement ete impliques dans les cas humains. Le developpement de methodes rapides pour la detection des STEC les plus impliques en pathologie humaine est donc essentiel pour assurer la securite des produits alimentaires. Cependant, la detection des STEC dans les aliments est problematique principalement en raison de la diversite des serogroupes de STEC et de l'absence de caracteristiques biochimiques communes permettant de les distinguer des autres E. coli.L'objectif de cette these etait d’optimiser le protocole de detection des STEC dans les aliments de maniere a pouvoir proposer aux industriels des protocoles leur permettant une reelle maitrise du « danger STEC » dans leur filiere.Pour se faire, nous sommes intervenus a differentes etapes du protocole. Nous avons notamment selectionne un milieu d’enrichissement permettant la detection des E. coli O26 dans les fromages au lait cru : EPT+ acriflavine + CT. Nous avons egalement evalue les performances d’une methode de detection des E. coli O157 :H7 (VIDAS ECPT UP) dans la viande de boeuf. Cette nouvelle technique est basee sur l’utilisation de proteines recombinante de phage qui ciblent specifiquement les E. coli O157. A travers cette etude, nous avons demontre la possibilite d’avoir des temps d’enrichissement minimes pour l’analyse d’echantillon de 25g (6h) et la faisabilite d’analyser des echantillons de 375g avec un ratio de dilution de ¼ et un enrichissement de 24h. Enfin nous nous sommes interesses a l’etape de confirmation en mettant au point un test d’immuno-concentration automatise (utilisant des proteines de phages specifiques de nos bacteries cibles) permettant d’immuno-concentrer les 5 serogroupes les plus connus de STEC (O26, O103, O111, O145 et O157) en une seule fois
Polymorphism in the Promoter Region of SEMA5A Is Associated with Sociality Traits in Korean Subjects with Autism Spectrum Disorders

In this study, we evaluated the association between autism spectrum disorders (ASDs) and 10 single-nucleotide polymorphisms (SNPs) in the 5' region of the semaphorin 5A gene (SEMA5A) for 250 Korean trios including children with ASDs. Family-based association testing and haplotype analysis revealed a statistically significant association between rs194085 and multiple sociality traits with Korean ASDs in the dominant model (p<0.001, corrected p=0.035). This indicates that genetic variations in the 5' region of SEMA5A play a role in the genetic predisposition to sociality traits in Korean ASDs.
Nonlinear vibration of fluid-conveying carbon nanotube using homotopy analysis method

Nonlinear vibration analysis of a single-walled carbon nanotube, using the Eringen nonlocal elasticity and Euler-Bernoulli beam theories, is carried out. Pasternak-type foundation and the simply-supported boundary conditions are assumed for the carbon nanotube and the governing equation of motion is developed using those theories. The Galerkin method is utilized to obtain the nonlinear ordinary differential equation of vibration of the single-walled carbon nanotube and the homotopy analysis method is employed to determine its nonlinear natural frequency. A parametric sensitivity study is then carried out. Few of the parameters were the axial tension, nonlocal parameter, fluid velocity and the foundation stiffness. The parametric study is mainly focused on the nonlinear natural frequency of single-walled carbon nanotube. Finally, a numerical simulation is carried out to determine the accuracy of the obtained results. Furthermore, an elliptical integral is utilized to verify the nonlinear natural frequency, which was obtained using the homotopy analysis method.
All-solid-state multimodal probe based on ISFET electrochemical microsensors for in-situ soil nutrients monitoring in agriculture

We report the design of a silicon chip dedicated to the in-situ monitoring of soil nitrogen cycle in wheat crop. Our study shows that ion-sensitive field effect transistor (ISFET) microsensors are suitable for quick on-site or long-term analysis of nutrients measured directly in soil as opposed to soil extracts analysis. Our pH-ISFET recorded soil pH for six months with results in good accordance with standard sampling method and without any loss of sensitivity. The adaptation of pH-ISFET in pNO3 and pNH4-ISFET allowed, for the first time, the in-situ measurements of natural variations of soil nitrogen contents caused by microorganisms' activity.
Planar Wireless Charging Technology for Portable Electronic Products and Qi

This paper discusses the recent system platforms based on planar charging as well on the first wireless power ABSTRACT | Starting from the basic principles of Tesla’s wireless power transfer experiment in the 1890s, this review article addresses the key historical developments of wireless power and its modern applications up to formation of the world’s first international wireless power standard ‘‘Qi’’ launched in 2010 for portable electronics. The scientific principles laid down by Nicolas Tesla for wireless power transfer, which still remain valid today, are first explained. Then, modern wireless power applications based on nonradiative (near-field) magnetic coupling for short-range applications are described. Some industrial application examples emerging since the 1960s are highlighted. The article then focuses on the comparison of the horizontal and vertical magnetic flux approaches developed in the early 1990s for low-power planar wireless charging pads. Several critical features such as localized charging, load identification, and freedom of positioning that are essential to wireless charging of portable electronic devices are explained. The core technologies adopted by the Wireless Power Consortium (WPC) for the ‘‘Qi’’ Standard in 2010 are summarized. Finally, the latest research and developments of wireless power transfer for midrange applications based on the domino-resonator concept and their future application poten-tial are described.
Plasmacytoid dendritic cells and autoimmune inflammation

Abstract Plasmacytoid dendritic cells (pDC) are a sub-population of dendritic cells (DC) that produce large amounts of type I interferon (IFN) in response to nucleic acids that bind and activate toll-like-receptor (TLR)9 and TLR7. Type I IFN can regulate the function of B, T, DC, and natural killer (NK) cells and can also alter the residence time of leukocytes within lymph nodes. Activated pDC can also function as antigen presenting cells (APC) and have the potential to prime and differentiate T cells into regulatory or inflammatory effector cells, depending on the context. In this review we discuss pDC ontogeny, function, trafficking, and activation. We will also examine how pDC can potentially be involved in regulating immune responses in the periphery as well as within the central nervous system (CNS) during multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE).
Functional performance measures: are they superior to self-assessments?

BACKGROUND It has been suggested that performance measures of functional status have several advantages over self-report measures for both clinical and research purposes, including: greater patient acceptability, interpretability, reproducibility, sensitivity to change, and the focus on actual ability rather than presumed capability. This article challenges this assumed superiority of "objective," "behavioral" measures by directly comparing self-assessments and blindly rated performance assessments on a specific item by task basis, using an identical rating format. METHODS A set of 14 performance tasks, consisting of a range of functional abilities (including simulations of cooking and sweeping), was administered to 99 community-dwelling older adults (aged 60-92) who had previously completed a 50-item instrumental activities of daily living (IADL) questionnaire. A subsample was retested 2 weeks later, and reassessed at 1 year. RESULTS Of 182 subjects willing and able to complete the IADL questionnaire, only 99 attempted at least one of the performance tasks. Tasks that took longer to complete were not necessarily associated with a greater number of errors, nor did accuracy ratings correspond well with difficulty ratings. Good correspondence (greater than 80% agreement) between observed and perceived difficulty was found for only one-third of the item/task matchings. Generally, the rater tended to underestimate difficulty relative to subjective assessments. CONCLUSIONS Relative to questionnaires, performance measures were not found to be psychometrically superior, more acceptable to respondents, easier to administer, or easier to interpret. Neither type of measure by itself distinguishes between motivation and capability, reflects adaptations made in everyday living, or accounts for personal preferences or reasons for difficulty.
Sex and Crossing over in Linkage Group IV of TRIBOLIUM CASTANEUM.

HE formal genetics of flour beetles of the genus Tribolium is still in its infancy. Although these organisms have found a habitat in the laboratories of the ecologist, the quantitative geneticist, and more recently, the population biologist (KING and DAWSON 1972) their use has been restricted by the availability of only a limited number of reliable mutants and further hampered by a meager knowledge of linkage relationships. At present there are 10 linkage groups corresponding to the 10 chromosomes of T. castaneum, the most widely used and genetically best known of the species in this genus. Although some of the linkage groups are represented by only a single gene, linkage group IV is one of the better marked, with some 11 loci that have been at least tentatively mapped ( SOKOLOFF 1966; SOKOLOFF, HOY and JOHNSON 1966; DAWSON 1972). One interesting feature associated with linkage group IV is a sex difference in the frequency of crossing over. SOKOLOFF (1963) reported no sex difference in a study of crossing over between two loci on this chromosome, but JOHNSON (1966) found a significant difference for the same two loci. During the course of studies with a new mutant in this linkage group, further information was collected on the sex difference in crossing over.
Abih tandeh : masyarakat desa di bawah rejim Orde Baru

Buku ini memberikan semacam testimoni tertulis tentang bagaimana pemerintah orde baru secara sistematis meluluhlantakkan struktur kekuasaan masyarakat adat, berkaitan dengan diberlakukannya UU No. 5 tahun 1979 tentang masyarakat desa.
An analysis of the CoRoT-2 system: A young spotted star and its inflated giant planet

Context: CoRoT-2b is one of the most anomalously large exoplanet known. Given its large mass, its large radius cannot be explained by standard evolution models. Interestingly, the planet's parent star is an active, rapidly rotating solar-like star with a large fraction (7 to 20%) of spots. Aims: We want to provide constraints on the properties of the star-planet system and understand whether the planet's inferred large size may be due to a systematic error on the inferred parameters, and if not, how it may be explained. Methods: We combine stellar and planetary evolution codes based on all available spectroscopic and photometric data to obtain self-consistent constraints on the system parameters. Results: We find no systematic error in the stellar modeling (including spots and stellar activity) that would yield the required ~10% reduction in size for the star and thus the planet. Two classes of solutions are found: the usual main sequence solution for the star yields for the planet a mass of 3.67+/-0.13 Mjup, a radius of 1.55+/-0.03 Rjup for an age that is at least 130Ma, and should be less than 500Ma given the star's fast rotation and significant activity. We identify another class of solutions on the pre-main sequence, in which case the planet's mass is 3.45\pm 0.27 Mjup, its radius is 1.50+/-0.06 Rjup for an age between 30 and 40 Ma. These extremely young solutions provide the simplest explanation for the planet's size which can then be matched by a simple contraction from an initially hot, expanded state, provided the atmospheric opacities are increased by a factor ~3 compared to usual assumptions for solar compositions atmospheres. Other solutions imply in any case that the present inflated radius of CoRoT-2b is transient and the result of an event that occurred less than 20 Ma ago: a giant impact with another Jupiter-mass planet, or interactions with another object in the system which caused a significant rise of the eccentricity followed by the rapid circularization of its orbit. Conclusions: Additional observations of CoRoT-2 that could help understanding this system include searches for infrared excess and the presence of a debris disk and searches for additional companions. The determination of a complete infrared lightcurve including both the primary and secondary transits would also be extremely valuable to constrain the planet's atmospheric properties and to determine the planet-to-star radius ratio in a manner less vulnerable to systematic errors due to stellar activity.
Circumcision for phimosis and other medical indications in Western Australian boys

TO THE EDITOR: Spilsbury et al argue that “improve education or physicians, and perhaps parents, with regard to foreskin development and management is required. ”1 However, updating of textbooks and medical curricula is required to accomplish this objective. Articles by Caldamone et al2 and Cendron et al are two examples of incorrect data in text books. Gairdner was the first to provide data on the normal development of the foreskin in young boys.4 Gairdner incorrectly believed that 92% of boys would have a retractile prepuce by age 5 years. Unfortunately, Gairdner’s data was wrong.5 Gairdner achieved his artificially high rate of retractability by first “running a probe around the preputial space” to break the normal physiological fusion between the foreskin and glans penis,4 a procedure few would recommend today because of pain, trauma, risk of infection, and iatrogenic creation of adhesions. As stated above, some textbooks continue to uncritically parrot Gairdner’s incorrect data. The error has been further compounded by the confusing presentation of data in Øster’s otherwise excellent study.6 Øster presents information about the incidence of “phimosis”, “tight foreskin”, and “adhesions” in separate tables. To obtain the percentage of boys in each age group with partially or completely non-retractile foreskins, it is necessary to sum the percentage incidence of these conditions. When that is done, Øster’s data are very similar to those provided by Kayaba et al7 on the development of the retractile prepuce. Therefore, according to current research, about 50% of boys will have a retractile prepuce by age 10 years and about 99% will have a retractile prepuce by the completion of puberty. The non-retractile foreskin is normal in boys and no cause for concern. Based on the data of Øster6 and Kayaba et al,7 Doctors Opposing Circumcision believes that the new rule-ofthumb should be that about 50% of boys will have a retractile prepuce by age 10 and about 99% will have a retractile prepuce by the completion of puberty. This information needs to be incorporated into textbooks, medical curricula, and information provided to the public. When the normal development of the prepuce is properly understood, one can easily see that patiently awaiting the natural development of preputial retractability will usually eliminate the need for medical or surgical intervention. Better information about the normal development of the foreskin should relieve parental anxiety and reduce false diagnoses of phimosis in boys.
The ‘Holy Plane’ of Rectal Surgery

The surgical plane For me surgery is primarily a craft and I see little shame in regarding a surgeon as a person who exists to do operations. Of course to know when not to do them and to be humane and honest with the patients is also of immense importance and there are many facets of our lives which perhaps transcend mere operative skill or technique. Nevertheless, this is the story of a simple artisan's pleasure in the actual style of performing an operation in essence the way to use a pair of scissors to define and develop a plane in a precise manner. The unique nature of this skill and its difference from the skills of carving the Sunday joint provide an excellent excuse for all surgeons whose wives seem unimpressed by their efforts in this other important field. A surgical plane is a potential space between contiguous organs which can be reproducibly created by dissection. In many cases a clue to the existence of the plane is provided by a glimpse, through the window of its peritoneal covering, of mobility between (forexample) a visceral structure (e.g, the mesorectum) and the somatic structures which surround it. It has long been a strong personal preference to find these planes around the gut and its derivatives with exasperating slowness. Thus, when armed with one of the early SPTU guns which Professor John Goligher had introduced to me, I set off on my 'Have gun, will travel' exploits. My desire to move the tissues back and forth in search of the perfect mobile lubricated plane led to real embarrassment with some of my host surgeons who supposed that some inexplicable and perhaps fatal 'fiddling inertia' had overtaken their guest who had after all been invited to 'fire the gun'. In developing these planes there are thus three basic principles: (1) Recognition ofmobility between tissues ofdifferent embryological origins. (2) Sharp dissection under direct vision in a good light. (3) Gentle opening of the plane by continuous traction with no actual tearing. 'The job of the Assistant is to put the tissues on stretch' (Lawrie)'.
Patterns and predictors of unplanned hospitalization in a population-based cohort of elderly patients with GI cancer.

PURPOSE Hospitalizations among patients with cancer are common and costly and, if unplanned, may interrupt oncologic treatment. The rate of unplanned hospitalizations in the population of elderly patients with cancer is unknown. We sought to describe and quantify patterns and risk factors for early unplanned hospitalization among elderly patients with GI cancer. PATIENTS AND METHODS We conducted a retrospective cohort study using linked Texas Cancer Registry and Medicare claims data from 2001 to 2009. Texas residents age 66 years or older initially diagnosed with GI cancer between 2001 and 2007 were included in the study. The unplanned hospitalization rate was estimated, and reasons for unplanned hospitalization were evaluated. Risk factors were identified using adjusted Cox proportional hazards modeling. RESULTS Thirty thousand one hundred ninety-nine patients were included in our study, 59% of whom had one or more unplanned hospitalizations. Of 60,837 inpatient claims, 58% were unplanned. The rate of unplanned hospitalization was 93 events per 100 person-years. The most common reasons for unplanned hospitalization were fluid and electrolyte disorders, intestinal obstruction, and pneumonia. Multivariable analysis showed that black race; residing in census tracts with poverty levels greater than 13.3%; esophageal, gastric, and pancreatic cancer; advanced disease stage; high Charlson comorbidity index score; and dual eligibility for Medicare and Medicaid increased the risk for unplanned hospitalization (all P values < .05). CONCLUSION Unplanned hospitalizations among elderly patients with GI cancer are common. Some of the top reasons for unplanned hospitalization are potentially preventable, suggesting that comorbidity management and close coordination among involved health care providers should be promoted.
Trends in the Usage of ISI Bibliometric Data: Uses, Abuses, and Implications

Librarians rely on the Institute for Scientific Information's journal impact factor as a tool for selecting periodicals, primarily in scientific disciplines. A current trend is to use this data as a means for evaluating the performance of departments, institutions, and even researchers in academic institutions—a process that is now being tied to tenure and promotion—despite the fact that such usage can be misleading and prejudicial. This paper will highlight the history of the development of impact factors, describe the limitations in their use, and provide a critique of the usage of impact factors in academic settings.
Sedative, anxiolytic and analgesic effects of Urena sinuata L. leaf extract in animal models

The sedative and analgesic potential of Urena sinuata L. was investigated for the first time in this study. The crude methanol extract of Urena sinuata L. leaves was evaluated for its central nervous system (CNS) depressant effect using rodent behavioral models. Methanol extract of Urena sinuata at a dose of 400 mg/kg body weight, displayed a suppressive effect on motor activity, exploratory behavior (in hole cross and open field tests) and prolongation of thiopental induced sleeping time in mice. In the elevated plus-maze (EPM) test, the same dose of methanol extract significantly (p < 0.05) increased the time spent by the treated mice in EPM open arms. Analgesic potential of the extract was also evaluated for centrally acting analgesic activity using formalin induced licking response model and for peripheral analgesic action using acetic acid-induced writhing test and tail immersion tests. In formalin induced licking response model, a significant (p < 0.05) inhibition of pain compared to reference drug diclofenac sodium was observed. In acetic acid-induced writhing test and tail immersion test, the extract at 200 mg/kg body weight produced a significant reduction of writhing response and pain respectively. These results evidenced the potential sedative and analgesic effects of Urena sinuata leaves.