Miracle-dz/UniFAR-FTUs huggingface dataset:
A regional Industrial Symbiosis methodology and its implementation in Geneva, Switzerland

The Agenda 21 for the Geneva region is the results from a broad consultation process including all local actors. The article 12 stipulates that « the State facilitates possible synergies between economic activities in order to minimize their environmental impacts » thus opening the way for Industrial Ecology (IE) and Industrial Symbiosis (IS). An Advisory Board for Industrial Ecology and Industrial Symbiosis implementation was established in 2002 involving relevant government agencies. Regulatory and technical conditions for IS are studied in the Swiss context. Results reveal that the Swiss law on waste does not hinder by-product exchanges. Methodology and technical factors including geographic, qualitative, quantitative and economical aspects are detailed. The competition with waste operators in a highly developed recycling system is also tackled.The IS project develops an empirical and systematic method for detecting and implementing by-products synergies between industrial actors disseminated throughout the Geneva region. Database management tool for the treatment of input-output analysis data and GIS tools for detecting potentials industrial partners are constantly improved. Potential symbioses for 17 flows (including energy, water and material flows) are currently studied for implementation.
A Novel Approach to an Multi-Cloud Data Hosting For Protection Optimization and Security

Numerous associations and ventures stores information into the cloud to diminish upkeep cost and urthermore to expand unwavering quality of information. While facilitating their information into cloud, client faces many cloud merchants and in addition their evaluating approaches so that the client may get mistaken for which cloud(s) are reasonable for putting away information. CHARM propose an information facilitating plan which consolidate two key capacities initially capacity is choosing a cloud to store information in least cost and ensured accessibility and second is activating move procedure to re-appropriate information. It can do as per evaluating of mists and varieties of information examples. While sending information to Third-Party regulatory control in cloud, it additionally turns into an issue identified with security. We require high safety efforts to ensure information in a cloud so we utilize DROPs idea that settles security and execution issue. In this we isolate information into parts and imitate that pieces into cloud hubs and every hub contain just a solitary information. Every one of these hubs are isolated with a specific separation utilizing diagram T-shading. Utilizing this security and execution streamlining is finished.
Plasma B-type natriuretic peptide predicts atrial fibrillation during rehabilitation after cardiac surgery

Background B-type natriuretic peptide (BNP) levels are known to predict atrial fibrillation (AF) occurrence short-term after cardiac surgery, but no information is available on their predictive potential at a later time point. We evaluated whether BNP levels predict postcardiac surgery AF events occurring during rehabilitation program. AF impact on hospitalization length and rehabilitation program have also been evaluated. Methods and results One hundred and forty-nine patients who underwent cardiac surgery were monitored for ‘late’ AF, defined as AF occurring during the rehabilitation period (20 ± 5 days) in contrast to ‘early’ AF defined as AF documented in the surgical department soon after surgery. BNP was determined at rehabilitative hospital admission (10 ± 5 days after surgery). Late AF was observed in 17% of patients. AF patients had higher BNP levels than event-free patients (459 ± 209 vs. 401 ± 449 pg/ml, P = 0.01). Lower kaliemia values (P = 0.048), early AF (P < 0.001), and combined surgery (coronary artery by pass graft and valve replacement; P = 0.016) were also associated with late AF. At multivariate analysis, BNP levels more than 322 pg/ml (P = 0.02), and early AF (P = 0.003) showed an independent association with late AF occurrence, which did not interfere with the physical training program but prolonged hospitalization (22 ± 5 vs. 20 ± 5 days, P = 0.062) and telemetry monitoring (6 ± 5 vs. 1 ± 3 days, P < 0.001). Conclusion BNP levels measured at the beginning of the rehabilitation program are independent predictors of late AF after cardiac surgery. These results suggest a more aggressive therapeutical approach during the rehabilitation period in patients with elevated BNP levels who have already experienced AF in the surgical department. Eur J Cardiovasc Prev Rehabil 15:460-466 © 2008 The European Society of Cardiology
Sharia Banking Opportunities and Challenges in the Digital Era

—The Indonesian government in the era of President Joko Widodo had a big vision in the digital economy sector. Jokowi is targeting Indonesia in 2020 to become the largest digital economic power in ASEAN, with e-commerce transaction projection values reaching 130 million US dollars. Indonesia's population currently reaches 262 million people. More than 50 percent or about 143 million people have been connected to the internet throughout 2017, report the Indonesian Internet Service Providers Association (APJII). In era disruption in the progress of financial technology, there has been a problem how are the opportunities and challenges of Islamic banking in the digital era? with SWOT analysis revealing the opportunities and challenges of using financial technology in Islamic banking services. The use of financial technology that is in line with regulations makes good opportunities to improve the quality of Islamic banking services for the convenience and security of customers. However, the application of financial technology also contains challenges for banks. The presence of financial technology raises a more variative financing model with lower costs and fast service. So that the existence of the role of banking institutions can be displaced/ threatened.
REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY The Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders

Serotonin is an important gastrointestinal signaling molecule. It is a paracrine messenger utilized by enterochromaffin (EC) cells, which function as sensory transducers. Serotonin activates intrinsic and extrinsic primary afferent neurons to, respectively, initiate peristaltic and secretory reflexes and to transmit information to the central nervous system. Serotonin is also a neurotransmitter utilized by a system of long descending myenteric interneurons. Serotonin is synthesized through the actions of 2 different tryptophan hydroxylases, TpH1 and TpH2, which are found, respectively, in EC cells and neurons. Serotonin is inactivated by the serotonin reuptake transporter (SERT)-mediated uptake into enterocytes or neurons. The presence of many serotonin receptor subtypes enables selective drugs to be designed to therapeutically modulate gastrointestinal motility, secretion, and sensation. Current examples include tegaserod, a 5-HT4 partial agonist, which has been approved for treatment of irritable bowel syndrome (IBS) with constipation in women and for chronic constipation in men and women. The 5-HT3 antagonists, granisetron and ondansetron, are useful in combating the nausea associated with cancer chemotherapy, and alosetron is employed in the treatment of IBS with diarrhea. Serotonergic signaling abnormalities have also been putatively implicated in the pathogenesis of functional bowel diseases. Other compounds, for which efficacy has not been rigorously established, but which may have value, include tricyclic antidepressants and serotonin selective reuptake inhibitors to combat IBS, and 5-HT1 agonists, which enhance gastric accommodation, to treat functional dyspepsia. The initial success encountered with serotonergic agents holds promise for newer and more potent insights and therapies of brain-gut disorders.
Secret Sharing Scheme: Securing data in multi-clouds using systmatic Secret sharing methods

Cloud storages have many exciting features that attract many individuals and organizations for storing and sharing data over the cloud. However, security and key management are still remaining the highlighted concerns in cloud storage. Managing/protecting keys is a problem for existing approaches, and opens the risk of attackers working to offline brute-force crack the decryption and/or surreptitiously obtaining the key and using it offline. To address these issues, we propose the CloudStash scheme, a system that applied the secret-sharing scheme directly on the file to store multi-shares of a file into multi-clouds. CloudStash utilizes secret-sharing, low cost cloud storages and multi-threading to improve confidentiality, availability, performance and fault tolerance. CloudStash achieves this improvement by splitting a file into multi-shares of secret and distributing these multi-shares into multi-clouds simultaneously where threshold shares are required to reconstruct the file. Our experiments show that CloudStash is statistically significantly faster for small files, and even for large files the added cost is not statistically worse. So the added security benefits are nearly free from the users’ perspective.
Brainstem microstimulation differentially inhibits pudendal motoneuron reflex inputs

SENSORY information from the genitourinary tract is transmitted to perineal muscle reflex circuits in the spinal cord and to the medullary reticular formation (MRF). This is the first report of a functional descending connection between neurons in the MRF and sensory inputs of the pudendal motoneuron reflex circuitry. In anesthetized rats, microstimulation of the MRF produced a decrease in amplitude and increase in latency of pudendal motoneuron reflex discharges (PMRD) elicited by stimulation of the dorsal nerve of the penis. No effects on pelvic nerve-elicited PMRD were found. The most robust reflex depression was observed when the lateral paragigantocellular reticular nucleus was microstimulated bilaterally. Reproductive abnormalities that occur following severe spinal cord injury probably result from disruption of these descending connections.
Crystal Structure of Reduced and of Oxidized Peroxiredoxin IV Enzyme Reveals a Stable Oxidized Decamer and a Non-disulfide-bonded Intermediate in the Catalytic Cycle*

Background: Peroxiredoxin IV metabolizes endoplasmic reticulum-derived hydrogen peroxide. Results: Peroxiredoxin IV structures reveal an unusually stable decamer and a sulfenylated intermediate in the enzymatic cycle. Conclusion: The enzymatic cycle of peroxiredoxin IV involves destabilization of the active site followed by formation of a stable disulfide-bonded decamer. Significance: Elucidating peroxiredoxin structures is required to understand how they function during oxidative stress. Peroxiredoxin IV (PrxIV) is an endoplasmic reticulum-localized enzyme that metabolizes the hydrogen peroxide produced by endoplasmic reticulum oxidase 1 (Ero1). It has been shown to play a role in de novo disulfide formation, oxidizing members of the protein disulfide isomerase family of enzymes, and is a member of the typical 2-Cys peroxiredoxin family. We have determined the crystal structure of both reduced and disulfide-bonded, as well as a resolving cysteine mutant of human PrxIV. We show that PrxIV has a similar structure to other typical 2-Cys peroxiredoxins and undergoes a conformational change from a fully folded to a locally unfolded form following the formation of a disulfide between the peroxidatic and resolving cysteine residues. Unlike other mammalian typical 2-Cys peroxiredoxins, we show that human PrxIV forms a stable decameric structure even in its disulfide-bonded state. In addition, the structure of a resolving cysteine mutant reveals an intermediate in the reaction cycle that adopts the locally unfolded conformation. Interestingly the peroxidatic cysteine in the crystal structure is sulfenylated rather than sulfinylated or sulfonylated. In addition, the peroxidatic cysteine in the resolving cysteine mutant is resistant to hyper-oxidation following incubation with high concentrations of hydrogen peroxide. These results highlight some unique properties of PrxIV and suggest that the equilibrium between the fully folded and locally unfolded forms favors the locally unfolded conformation upon sulfenylation of the peroxidatic cysteine residue.
Spousal Understanding of Patient Quality of Life: Implications for Surrogate Decisions

Most guidelines for surrogate decision making for mentally incapacitated patients who once had decision-making capacity recommend that patient preferences be approximated based on previous written or verbal communication (direct evidence) or, if these are unavailable, knowledge of the patient’s values (indirect evidence). This approach, known as the substituted-judgment standard
Susceptibilities of 428 gram-positive and -negative anaerobic bacteria to Bay y3118 compared with their susceptibilities to ciprofloxacin, clindamycin, metronidazole, piperacillin, piperacillin-tazobactam, and cefoxitin

The susceptibilities of 428 gram-negative and gram-positive anaerobes (including selected cefoxitin-resistant strains) to Bay y3118 (a new fluoroquinolone), ciprofloxacin, clindamycin, metronidazole, cefoxitin, piperacillin, and piperacillin-tazobactam were tested. Organisms comprised 115 Bacteroides fragilis group, 116 non-B. fragilis Bacteroides, Prevotella, and Porphyromonas spp. , 40 fusobacteria, 58 peptostreptococci, 48 gram-positive non-spore-forming rods, and 51 clostridia. beta-Lactamase production was demonstrated in 87% of the gram-negative rods but in none of the gram-positive organisms. Overall, Bay y3118 was the most active agent, with all organisms inhibited at an MIC of < or = 2.0 micrograms/ml (MICs for 50% [MIC50] and 90% [MIC90] of strains tested, 0.125 and 0.5 microgram/ml, respectively). By contrast, ciprofloxacin was much less active, with only 42% of strains susceptible at a breakpoint of 2.0 micrograms/ml (MIC50, 4.0 micrograms/ml; MIC90, 16.0 micrograms/ml). Metronidazole was active against all gram-negative rods, but 7% of peptostreptococci, 83% of gram-positive non-spore-forming rods, and 4% of non-Clostridium perfringens, non-Clostridium difficile clostridia were resistant to this agent (MICs, > 16.0 micrograms/ml). Clindamycin was active against 94% of Bacteroides, Prevotella, and Porphyromonas spp. , 91% of peptostreptococci, and 100% of gram-positive non-spore-forming rods, but was active against only 70% of fusobacteria and 53% of clostridia. Cefoxitin was active against > or = 90% of all groups except the B. fragilis group and non-Propionibacterium acnes gram-positive non-spore-forming rods (both 85%) and C. difficile (20%). Significant enhancement of piperacillin by tazobactam was seen in all beta-lactamase-positive strains (99% susceptible; MIC90, 8.0 micrograms/ml), and all beta-lactamase-negative strains were susceptible to piperacillin (MIC90, 8.0 micrograms/ml). Clinical studies are required to delineate the role of Bay y3118 in the treatment of anaerobic infections.
Discovery and characterization of electron transfer proteins in the photosynthetic bacteria 1

Research on photosynthetic electron transfer closely parallels that of other electron transfer pathways and in many cases they overlap. Thus, the first bacterial cytochrome to be characterized, called cytochrome c2, is commonly found in non-sulfur purple photosynthetic bacteria and is a close homolog of mitochondrial cytochrome c. The cytochrome bc1 complex is an integral part of photosynthetic electron transfer yet, like cytochrome c2, was first recognized as a respiratory component. Cytochromes c2 mediate electron transfer between the cytochrome bc1 complex and photosynthetic reaction centers and cytochrome a-type oxidases. Not all photosynthetic bacteria contain cytochrome c2; instead it is thought that HiPIP, auracyanin, Halorhodospira cytochrome c551, Chlorobium cytochrome c555, and cytochrome c8 may function in a similar manner as photosynthetic electron carriers between the cytochrome bc1 complex and reaction centers. More often than not, the soluble or periplasmic mediators do not interact directly with the reaction center bacteriochlorophyll, but require the presence of membrane-bound intermediates: a tetraheme cytochrome c in purple bacteria and a monoheme cytochrome c in green bacteria. Cyclic electron transfer in photosynthesis requires that the redox potential of the system be delicately poised for optimum efficiency. In fact, lack of redox poise may be one of the defects in the aerobic phototrophic bacteria. Thus, large concentrations of cytochromes c2 and c′ may additionally poise the redox potential of the cyclic photosystem of purple bacteria. Other cytochromes, such as flavocytochrome c (FCSD or SoxEF) and cytochrome c551 (SoxA), may feed electrons from sulfide, sulfur, and thiosulfate into the photosynthetic pathways via the same soluble carriers as are part of the cyclic system. Abbreviations: FCSD – flavocytochrome c sulfide dehydrogenase; FNR – ferredoxin NADP reductase; HiPIP – high potential iron–sulfur protein; RBC – Rieske iron–sulfur protein/cytochrome b/cytochrome c complex; RC – reaction center; SQR – sulfide quinone reductase
NO ASSOCIATION OF COMPLEMENT FACTOR H GENE POLYMORPHISM AND AGE-RELATED MACULAR DEGENERATION IN THE JAPANESE POPULATION

Purpose: The aim of this study was to determine whether genetic polymorphism of complement factor H (CFH) is associated with age-related macular degeneration (AMD) in the Japanese population. Methods: Genomic DNA was examined in a cohort of 67 Japanese patients with AMD and 107 controls. TT/TC/CC genotypes on exon 9 were screened for sequence alternation by polymerase chain reaction analysis and through sequencing. Results: The mean ages ± SD of AMD patients and control subjects were 73 ± 8.5 years and 72 ± 8.7 years, respectively. There was no significant difference between CFH genotypes in the AMD group (TT, 76%; TC, 19%; CC, 5%) and the control group (TT, 80%; TC, 17%; CC, 3%). The frequencies of T and C alleles were 86% and 14%, respectively, in the AMD group and 89% and 11%, respectively, in the control group. Conclusion: CFH gene polymorphism is not associated with AMD in the Japanese population. Moreover, the frequency of the C allele is low among the Japanese population.
The End of the “ Two Solitudes ” ?

It is useful to discuss the origins of this text as they highlight the underlying problem it aims to discuss. When I was director of the School of Canadian Studies at Carleton University, I received a phone call from a colleague at the University of Ottawa. One of his students wanted to take a course, taught in English, dealing with the broad question of French and English relations Canada. The discipline ~sociology, political science, history, literature! did not matter, as long as the theme was discussed. After looking at the list of courses offered by my own university, I saw that none matched this student’s interests. There were a few courses regarding Quebec politics, history, and literature, but none that focused specifically on the relations between French and English societies in Canada. My first observation was that in Ottawa, the “national” capital of Canada, it was impossible for a student to learn about one of the main aspects of Canada’s social, cultural and political life. A few months later, I received a phone call from another colleague, at Laval University in Québec City. He wanted to know which French-
Syndrome de Kallmann (KS) : étude de corrélation phénotype/génotype et des modes de transmission de mutations PROK2 et PROKR2 : caractérisation d’un nouveau gène responsable de KS, l’alpha dystrobrévine

Le syndrome de Kallmann de Morsier (KS) est defini par l’association d’un hypogonadisme hypogonadotrope (HH) et d’une alteration de l’odorat, hyposmie ou anosmie.L’association d’anomalies du systeme olfactif avec un hypogonadisme a ete observee la premiere fois par Maestre de San Juan en 1956, un anatomopathologiste espagnol qui a decrit un sujet ayant des testicules de petite taille et l’absence de bulbes olfactifs (Maestre de San Juan 1856). En 1944, le psychiatre et geneticien americain Franz Josef Kallmann individualisa le syndrome au sein de 3 familles et fit l’hypothese de son caractere hereditaire (Kallmann et al. 1944). Dans les annees 50, l’anatomopathologiste suisse de Morsier approfondit la connaissance du syndrome en decrivant plusieurs cas d’absence complete ou partielle des bulbes et du tractus olfactif chez des patients masculins atteints d’hypogonadisme et d’anomalie anatomique de la ligne mediane (de Morsier 1954; de Morsier 1962; de Morsier and Gauthier 1963). Il appela ce syndrome « dysplasie olfactogenitale » et il fut le premier a suggerer l’origine hypothalamique de l’hypogonadisme. Enfin, en 1971, l’origine hypothalamique de l’hypogonadisme fut demontre, secondaire a un deficit en gonadoliberine (GnRH) (Naftolin et al. 1971).
Feasibility of conducting a randomized controlled trial to evaluate the effect of motivational interviewing on hearing-aid use

Abstract Objectives: The aim of this study was to evaluate the feasibility of conducting a randomized controlled trial (RCT) on the effect of motivational interviewing (MI) on hearing-aid use. Design: This was a pilot single-blind, randomized parallel-group study conducted in the UK. Study sample: Thirty-seven adult patients who reported using their hearing aid(s) less than four hours per day were randomized to MI combined with Standard Care (MISC) (n = 20), and Standard Care only (SC) (n = 17). Results: Of 220 patients invited, 37 were enrolled giving the recruitment rate of 17%. One participant withdrew giving the retention rate of 97%. It was feasible to combine MI with SC for facilitating hearing-aid use and deliver the intervention with high fidelity in an audiology setting. The measure on hearing-aid use (data logging) one month after interventions favoured the MISC group. Conclusions: This pilot study suggests that conducting an RCT on using MI for facilitating hearing-aid use in people who do not use their hearing aids is feasible, and that MI combined with SC may have more positive effects on hearing-aid use compared to SC only.
Cloning of Human PEX cDNA

Mutations in the PEX gene are responsible for X-linked hypophosphatemic rickets. To gain insight into the role of PEX in normal physiology we have cloned the human full-length cDNA and studied its tissue expression, subcellular localization, and peptidase activity. We show that the cDNA encodes a 749-amino acid protein structurally related to a family of neutral endopeptidases that include neprilysin as prototype. By Northern blot analysis, the size of the full-length PEXtranscript is 6.5 kilobases. PEX expression, as determined by semi-quantitative polymerase chain reaction, is high in bone and in tumor tissue associated with the paraneoplastic syndrome of renal phosphate wasting. PEX is glycosylated in the presence of canine microsomal membranes and partitions exclusively in the detergent phase from Triton X-114 extractions of transiently transfected COS cells. Immunofluorescence studies in A293 cells expressing PEX tagged with a c-myc epitope show a predominant cell-surface location for the protein with its COOH-terminal domain in the extracellular compartment, substantiating the assumption that PEX, like other members of the neutral endopeptidase family, is a type II integral membrane glycoprotein. Cell membranes from cultured COS cells transiently expressing PEX efficiently degrade exogenously added parathyroid hormone-derived peptides, demonstrating for the first time that recombinant PEX can function as an endopeptidase. PEX peptidase activity may provide a convenient target for pharmacological intervention in states of altered phosphate homeostasis and in metabolic bone diseases.