Miracle-dz/UniFAR-FTUs huggingface dataset:
The acute effects of exercise intensity on HDL-C metabolism.

To determine whether exercise intensity influences acute HDL-C responses, 12 male recreational runners (24.8 +/- 4 yr) who ran 15-30 miles.wk-1 exercised on a motor driven treadmill at 60% (L) and 75% (H) VO2max. A counterbalanced experimental design was utilized and energy expenditure was 800 Kcal. Fasting blood samples were obtained 24 h before exercise (24 PRE), immediately post-(IPE), 1 h post- (1 h PE), 6 h post- (6 h PE), and 24 h post- (24 h PE) exercise and analyzed for HDL-C and HDL2&3-C. In addition, postheparin plasma samples, obtained 24 h PRE, 6 h PE, and 24 h PE were analyzed for lipolytic activity--LPLA and HTGLA. An exercise trial by time interaction was observed for HDL-C (P < 0.01). Post-hoc analysis revealed no change in HDL-C following the L trial. However, an increase in HDL-C was observed 24 h PE (P < 0.01) following the H trial. The increase in HDL-C was attributed to an elevated HDL3-C (P < 0.01), with no change in HDL2-C. Analysis of plasma lipolytic activity revealed an increase in LPLA 24 h PE (P < 0.05) which may be responsible for the postexercise alterations in HDL-C. However, HTGLA decreased 6 h PE (P < 0.01) and 24 h PE (P < 0.05). We conclude that increases in HDL-C levels following endurance activity are influenced, in part, by the exercise intensity.
Functional Coupling of Glycosyl Transfer Steps for Synthesis of Gangliosides in Golgi Membranes from Neural Retina Cells (*)

The synthesis of the oligosaccharide of gangliosides is carried out in the Golgi complex by successive sugar transfers to proper glycolipid acceptors. To examine how the product of one glycosylation step couples with the next transfer step, the endogenous gangliosides of Golgi membranes from 14-day-old chick embryo retina were labeled from CMP-[3H]NeuAc or UDP-[3H]GalNAc or UDP-[3H]Gal in conditions which do not allow vesicular intercompartmental transport. After saturation of the endogenous acceptor capacity, labeling was mostly in the immediate acceptors of the corresponding labeled sugars. However, some labeled intermediates progressed to more glycosylated gangliosides if the membranes were incubated in a second step in the presence of the necessary unlabeled sugar nucleotides. This was particularly evident in the case of membranes incubated with UDP-[3H]Gal, in which most of the [3H]Gal-labeled lactosylceramide synthesized in the first step was converted to GM3 and GD3, or to GM2 or to GD1a in a second incubation step in the presence of unlabeled CMP-NeuAc alone, or together with UDP-GalNAc, or together with UDP-Gal plus UDP-GalNAc, respectively. Conversion was time dependent and dilution-independent. Since prior reports using brefeldin A indicate that transfer steps catalyzed by GalNAc-T, Gal-T2, and Sial-T4 localize in the trans-Golgi network (TGN), our results lead to the following major conclusions: (a) transfer steps catalyzed by GalNAc-T, Gal-T2, and Sial-T4 colocalize and are functionally coupled in the TGN; (b) proximal Golgi Gal-T1, Sial-T1, and Sial-T2, and their corresponding glycolipid acceptors, extend their presence to the TGN, and (c), GalNAc-T and Sial-T2 compete for a common pool of acceptor GM3 in the synthesis of GM2 and GD3.
Childhood epidermolysis bullosa acquisita with autoantibodies against the noncollagenous 1 and 2 domains of type VII collagen: case report and review of the literature

Epidermolysis bullosa acquisita (EBA) is an acquired subepidermal bullous disease characterized by IgG autoantibodies to type VII collagen, a major component of anchoring fibrils. Most patients with EBA are adult and develop autoantibodies to the noncollagenous (NC) 1 domain of type VII collagen. We describe a 4‐year‐old Japanese boy presenting pruritic vesicles and tense blisters over his whole body. Immunofluorescence studies revealed linear IgG/C3 deposits along the dermal–epidermal junction of the patient's skin, and circulating IgG autoantibodies mapping to the dermal side of 1 M NaCl‐split skin. By immunoblotting analysis using dermal extracts as a substrate, the patient's IgG antibodies labelled a 290‐kDa protein corresponding to type VII collagen. Immunoblotting studies using recombinant proteins demonstrated that the patient's circulating autoantibodies recognized not only the NC1 but also the NC2 domain of type VII procollagen. Review of the previously reported cases and the present case suggested that patients with EBA with autoantibodies to regions other than the NC1 domain are all children younger than 10 years of age with clinical features of an inflammatory phenotype.
Nitrogen metabolism in flag leaf and grain of wheat in response to irrigation regimes

Although scarcity of irrigation water is one of the key limiting factors for wheat production in many regions of the world, by using partial irrigation at strategic times during the growing season, it might be possible to enhance productivity. We measured the changes in various parameters related to nitrogen (N) metabolism in flag leaf and grain of wheat (Triticum aestivum L.) plants (cv. Jinan 17 and Lumai 21), which were subjected to five irrigation regimes until physiological maturity. Severely deficient or excessive irrigation during grain filling decreased the photosynthetic rate (A), the concentrations of N, free amino acid, and soluble protein, as well as the activities of nitrate reductase (NR) and glutamine synthetase (GS) and increased malondialdehyde (MDA) accumulation and endopeptidase (EP) activity, though grain protein concentration might mainly depend on genotype. The activities of NR and GS were significantly positively correlated with A, but those of EP were significantly negatively correlated with A. The results indicate that while severe water stress aggravates the adverse effect on nitrogen metabolism, excessive soil moisture is also not useful during the grain-filling stage, resulting in lower grain yield and quality. Our results suggest that applying an optimal irrigation regime in wheat fields still plays an important role in the improvement of grain yield and quality.
Management Pattern of Self-Made Equipment Entire Process in Manufacturing Enterprise Based on Knowledge Management

From the perspective of process management of self-made equipment in manufacturing enterprise, this paper analyzes shortages of the existing equipment management patterns, with the combination of knowledge management idea and method, establishes the knowledge management pattern of self-made equipment entire process in manufacturing enterprise, studies the expression way of knowledge objectives, knowledge acquisition approach and knowledge diffusion and sharing method, which exist in the process of the equipment’s design and maintenance, and finally, resolves knowledge cohesion and feedback problem between equipment design, operation and maintenance processes.
Frequency-based energy management of stand-alone systems: Design of the control parameters for high versatility

Frequency-based energy management strategies have been proposed for stand-alone systems with either centralized or distributed energy storage. This paper proposes a methodology for the design of the control parameters which ensures stability in both type of systems. As a result, the inverter manufacturer can implement one sole strategy, regardless of whether the expected stand-alone system is centralized or distributed. In addition, the battery inverter becomes more versatile since it can be used alone or in parallel with other battery inverters. Simulation results corroborate the theoretical analysis and demonstrate that energy management is carried out with no need of communication cables for a system with 1, 2 or 3 battery inverters with the same firmware.
Parcellisation et analyse multi-niveaux de données IRM fonctionnelles. Application à l'étude des réseaux de connectivité cérébrale. (Multi-level parcellation and analysis of fMRI data - Application to the study of brain functional networks)

Durant les dernieres decennies, l'IRM fonctionnelle a permis de cartographier les differentes fonctions cerebrales et, plus recemment, d'identifier les reseaux fonctionnels qui decrivent les interactions qui peuvent s'etablir entre regions cerebrales, proches ou distantes, lors de l'execution d'une tâche cognitive. Pour identifier ces reseaux, une strategie recente repose sur une parcellisation preliminaire du cerveau en regions fonctionnellement homogenes, puis sur l'identification des reseaux fonctionnels significatifs depuis une mesure des interactions entre l'ensemble des regions. Ainsi, la premiere partie de cette these propose une nouvelle methode de parcellisation du cerveau en regions fonctionnellement homogenes. La methode proposee est exploratoire et multi-niveaux : elle fournit plusieurs niveaux de parcellisation, et nous avons montre que les regions definies par notre methode se superposent de maniere satisfaisante aux structures anatomiques du cortex. Dans la deuxieme partie de la these, nous avons propose une methode originale d'identification des reseaux fonctionnels. L'approche developpee permet la significativite des reseaux etant donne leur taille et le seuil utilise pour leur detection. Une telle approche permet de detecter des reseaux de faible taille qui impliquent des liens tres significatifs, et egalement des reseaux plus grands impliquant des liens moins significatifs. Enfin, nous avons developpe une approche permettant de classer les reseaux obtenus, de maniere a realiser une etude de groupe. L'information disponible sur l'ensemble des sujets permet alors de definir des classes qui synthetisent les caracteristiques des reseaux les plus partages au sein d'une population de sujets.
A survey and comparative study of simulators for vehicular ad hoc networks (VANETs)

Wireless communication technologies have now greatly impact our daily lives. From indoor wireless LANs to outdoor cellular mobile networks, wireless technologies have benefited billions of users around the globe. The era of vehicular ad hoc networks (VANETs) is now evolving, gaining attention and momentum. Researchers and developers have built VANET simulation software to allow the study and evaluation of various media access, routing, and emergency warning protocols. VANET simulation is fundamentally different from MANETs (mobile ad hoc networks) simulation because in VANETs, vehicular environment imposes new issues and requirements, such as constrained road topology, multi-path fading and roadside obstacles, traffic flow models, trip models, varying vehicular speed and mobility, traffic lights, traffic congestion, drivers' behavior, etc. Currently, there are VANET mobility generators, network simulators, and VANET simulators. This paper presents a comprehensive study and comparisons of the various publicly available VANET simulation software and their components. In particular, we contrast their software characteristics, graphical user interface (GUI), popularity, ease of use, input requirements, output visualization capability, accuracy of simulation, etc. Finally, while each of the studied simulators provides a good simulation environment for VANETs, refinements and further contributions are needed before they can be widely used by the research community. Copyright © 2009 John Wiley & Sons, Ltd.
Putative Association of Fas and FasL Gene Polymorphisms with Clinical Outcomes of Hepatitis B Virus Infection

Objective:Fas/FasL polymorphisms, which are related to apoptosis, might influence the clearance of hepatitis B virus (HBV) infection and the occurrence of hepatocellular carcinoma (HCC). This study was performed to determine whether Fas and FasL promoter polymorphisms are associated with clinical outcome in chronic HBV infection. Methods: A total of 1,095 Korean subjects were prospectively allocated to two different groups: ‘the chronic carrier group’ (CC; n = 666), who were repeatedly hepatitis B surface antigen (HBsAg)-positive, and ‘the spontaneous recovery group’ (SR; n = 429), who were HBsAg-negative with antibodies to HBsAg and hepatitis B core antigen. In addition, the CC group was subcategorized into chronic hepatitis and HCC subgroups. Fas promoter polymorphisms at –1377G>A and –670A>G and the FasL promoter polymorphism at –844C>T were analyzed for and the genotype distributions of subjects were compared. Results: There were no significant associations between Fas or FasL promoter polymorphism with the HBV clearance and HBeAg clearance. However, –1377G>A in Fas promoter region showed protective effect to HCC occurrence (RH = 0.70, p = 0.03). Conclusions:Fas–1377G>A polymorphisms might be involved in the pathogenesis of human HCC.
Abnormalities of lipoprotein metabolism in patients with the nephrotic syndrome.

BACKGROUND AND METHODS Patients with the nephrotic syndrome characteristically have multiple abnormalities of lipoprotein metabolism, but the cause and exact nature of these abnormalities are uncertain. In this study, we measured serum lipids and apoproteins in 57 patients with the nephrotic syndrome. We also determined the kinetic indexes of low-density lipoprotein (LDL) metabolism in six patients, and again in three of the six after recovery. RESULTS The patients with the nephrotic syndrome had elevated serum concentrations of cholesterol, triglycerides, and phospholipids, which were confined to the lipoproteins containing apoprotein B. The serum concentrations of high-density lipoproteins and the associated A-I and A-II apoproteins were similar in the patients with the nephrotic syndrome and normal subjects. The relative proportions of lipids and their positive association with the increased serum concentrations of apoproteins B, C-II, C-III, and E suggest quantitative rather than qualitative differences in the lipoproteins. All the patients had lipiduria, which probably reflected the excretion of high-density lipoproteins, although no intact immunoreactive apoprotein A-I was found in urine. Serum albumin concentrations were inversely related to serum lipid concentrations in the patients, the severity of the hypoalbuminemia corresponding to the degree of change in serum lipoprotein concentrations. The kinetic studies of lipoprotein metabolism revealed an overproduction of LDL apoprotein B that returned to normal after recovery. CONCLUSIONS The elevated serum concentrations of LDL cholesterol, other lipids, and apoprotein B in patients with uncomplicated nephrotic syndrome are due to reversible increases in lipoprotein production.
Compressed Sensing High-accuracy Detection for Electric Power Interharmonics

Interharmonics frequencies are not integer multiple of the fundamental frequency, and interharmonics amplitudes are far less than fundamental amplitude and harmonics amplitudes, which mean high sensitivity to desynchronization problems, so it’s dificult to estimate interharmonics. In this paper, a new method based on random sparse sampling and compressed sensing (CS) Bregman technique was proposed to estimate the interharmonics. The random sam pling has following advantages; alias-free、sampling frequency need not obey the Nyquist limit、and higher frequency resolution. So the random sampling can measure the signals which their frequencies component are close, and can implement the higher frequencies measurement with lower sampling frequency. However,the rangdom sampling exists the noise in spectrum analysis, so it’s difficult to estimate the low amplitude signals. Compressed sensing can work out this problem by designing observation matrix and with the sparsity reconstruction of the signal in the Fourier domain; in addition, the application of CS can estimate the amplitudes and phases of the signals exactly. The results ofexperiments show that the proposed method can estimate the interharmonics exactly,even if the interharmonics frequencies are close the fundam ental frequency and interharmonics amplitudes are far less than fundamental am plitude；and can measure high order interharmonics with lower sam pling frequency.
Dynamics of a two-state quantum dot laser with saturable absorber

In this paper, we report on both experimental and theoretical investigations on the dynamics of self-pulsation regimes in a two-section QD laser that is operating simultaneously on the GS and ES transitions. We show that the competition between the two states results in anti-phase dynamics. We also found a sub-harmonic sequence that leads ultimately to chaos.
The I.F.A.S.T. model allows the prediction of conversion to Alzheimer disease in patients with mild cognitive impairment with high degree of accuracy.

This paper presents the results obtained with the innovative use of special types of artificial neural networks (ANNs) assembled in a novel methodology named IFAST (implicit function as squashing time) capable of compressing the temporal sequence of electroencephalographic (EEG) data into spatial invariants. The aim of this study is to test the potential of this parallel and nonlinear EEG analysis technique in providing an automatic classification of mild cognitive impairment (MCI) subjects who will convert to Alzheimer's disease (AD) with a high degree of accuracy. Eyes-closed resting EEG data (10-20 electrode montage) were recorded in 143 amnesic MCI subjects. Based on 1-year follow up, the subjects were retrospectively classified to MCI converted to AD and MCI stable. The EEG tracks were successively filtered according to four different frequency ranges, in order to evaluate the hypotheses that a specific range, corresponding to specific brain wave type, could provide a better classification (0.12 Hz, 12.2 - 29.8 Hz; 30.2 - 40 Hz, and finally Notch Filter 48 - 50 Hz). The spatial content of the EEG voltage was extracted by IFAST step-wise procedure using ANNs. The data input for the classification operated by ANNs were not the EEG data, but the connections weights of a nonlinear auto-associative ANN trained to reproduce the recorded EEG tracks. These weights represented a good model of the peculiar spatial features of the EEG patterns at scalp surface. The classification based on these parameters was binary and performed by a supervised ANN. The best results distinguishing between MCI stable and MCI/AD reached to 85.98%. (012 Hz band). And confirmed the working hypothesis that a correct automatic classification can be obtained extracting spatial information content of the resting EEG voltage by ANNs and represent the basis for research aimed at integrating spatial and temporal information content of the EEG. These results suggest that this low-cost procedure can reliably distinguish eyes-closed resting EEG data in individual MCI subjects who will have different prognosis at 1-year follow up, and is promising for a large-scale periodic screening of large populations at amnesic MCI subjects at risk of AD.
New effects in an ultracompact Young's double nanoslit with plasmon hybridization

We present a theoretical study on the anomalous transmission of an asymmetric Young's double metallic nanoslit with an ultrathin interval. The slit–slit interactions show exotic optical properties, particularly strong suppression of light transmission with narrow bandwidth and red/blue shifting of transmission peaks from individual slits, in contrast to currently well-developed subwavelength optical structures. Dip transmission is also observed to gradually decay with increasing interval distance. Analysis results reveal that such a phenomenon physically lies in the hybridized cross-talking of surface modes within two slits throughout the interval film in between. Depending on the plasmon hybridization type, either symmetric or antisymmetric, the newly induced optical phase retardation between the two slits can decrease and increase, respectively. This investigation suggests a potential way of nonlinearly bonding metallic waveguides and consequently aiding in the design of new plasmonic devices.
Ambulatory blood pressure monitoring and microalbuminuria in normotensive subjects with insulin-dependent diabetes mellitus.

OBJECTIVE To assess the association between microalbuminuria with ambulatory blood pressure monitoring in normotensive individuals with insulin-dependent diabetes mellitus. METHODS Thirty-seven patients underwent determination of the rate of urinary excretion of albumin through radioimmunoassay and ambulatory blood pressure monitoring. Their mean age was 26.5+/-6.7 years, and the mean duration of their disease was 8 (1-34) years. Microalbuminuria was defined as urinary excretion of albumin > or =20 and <200 microg/min in at least 2 out of 3 urine samples. RESULTS Nine (24.3%) patients were microalbuminuric. Ambulatory blood pressure monitoring in the microalbuminuric patients had higher mean pressure values, mainly the systolic pressure, during sleep as compared with that in the normoalbuminuric patients (120.1+/-8.3 vs 110.8+/-7.1 mmHg; p=0.007). The pressure load was higher in the microalbuminuric individuals, mainly the systolic pressure load during wakefulness [6.3 (2.9-45.9) vs. 1.6 (0-16%); p=0.001]. This was the variable that better correlated with the urinary excretion of albumin (r(S)=0.61; p<0.001). Systolic pressure load >50% and diastolic pressure load > 30% during sleep was associated with microalbuminuria (p=0.008). The pressure drop during sleep did not differ between the groups. CONCLUSION Microalbuminuric normotensive insulin-dependent diabetic patients show greater mean pressure value and pressure load during ambulatory blood pressure monitoring, and these variables correlate with urinary excretion of albumin.
As easy as ABC? Primary prevention of sexually transmitted infections

Uganda’s ABC programme has led to dramatic decreases in HIV infection rates for over a decade. No country in the world has seen its HIV incidence fall through condom promotion alone. Changes in primary sexual behaviour are always present when HIV rates decline. Safer sex is first about partner choice and then condom use, but both are important. There are valid criticisms of the ABC approach but its critics and proponents alike should work together if the Ugandan success is to be maintained and replicated in other countries. In this issue, Genuis and Genuis draw renewed attention to the success of the ABC strategy (abstinence, being faithful, condom use) in reducing HIV infection rates in Uganda. They suggest that this approach will provide “an adaptable framework for …STD prevention programmes in other nations”. 1 Although initially, there was much debate about the reality of the Ugandan success, few now dispute the overwhelming evidence showing both the extent and duration of the reduction of HIV infection.2 HIV prevalence in Uganda declined from 21.1% to 9.7% from 1991 to 1998 across 15 antenatal clinics, with the greatest declines among the younger age groups. In 21 year old army recruits, the decline was from 18.5% to 4% (1991–2002) and among blood donors, HIV prevalence fell from 24% to 7% (1989–1998). 3 While there was some geographical variation, HIV prevalence fell in both urban and rural areas and in both men and women. There also continues to be a decline in the incidence of HIV in Uganda with a 37% decrease in HIV-1 incidence between the years 1995–99 compared with 1990–94 in a recently reported study.4 As incidence is a better measure of the future trends of the disease than prevalence, it seems probable that Ugandan HIV rates will continue to decline …
Linear sparse feature based face detection in gray images

A very simple algorithm is used to construct an over complete set of linear sparse feature based classifiers, and AdaBoost algorithm is adopted to select part of them to form a strong classifier. During the course of feature extraction and selection, the new method minimizes the classification error directly, whereas most previous works cannot do this. An important difference between this method and other methods is that the sparse features are learned from the training set, instead of being arbitrarily defined. Experiments demonstrate that the new algorithm performs quite well.