Miracle-dz/UniFAR-FTUs huggingface dataset:
Reducing the effect of sample bias for small data sets with double‐weighted support vector transfer regression

Small data sets are an extremely challenging problem in the machine learning (ML) realm, and in specific, in regression scenarios, as the lack of relevant data can lead to ML models that have large bias. However, there are many applications for which a purely data‐driven procedure would be advantageous, but a large amount of data are not available. This article proposes a novel regression‐based transfer learning (TL) model to address this challenge, where TL is defined as knowledge transfer from a large, relevant data set (source domain data) to a small data set (target domain data). The proposed TL model is termed double‐weighted support vector transfer regression (DW‐SVTR), which couples least squares support vector machines for regression (LS‐SVMR) with two weight functions. The first weight function uses kernel mean matching (KMM) to reweight the source domain data such that the mean values of the source and target domain data in a reproduced kernel Hilbert space (RKHS) are close. In this way, the source domain data points relevant to the target domain points have a larger weight than irrelevant source domain points. The second weight is a function of estimated residuals, which aims to further reduce the negative interference of irrelevant source domain points. The proposed approach is assessed and validated via simulated data and by enhanced shear strength prediction of nonductile columns based on limited availability of nonductile column data. Specifically, the results for the latter show that the proposed DW‐SVTR can reduce the root mean square error (RMSE) by 34% and enhance the coefficient of determination (R2) by 229%. These numerical results demonstrate that the DW‐SVTR significantly reduces the effect of small sample bias and improves prediction performance compared to standard ML methods.
Age structure of boreal willows and fluctuations in herbivore populations

The age structure, both on the ramet and the genet level of boreal willow populations ( Salix myrsinifolia-phylicifolia ) was studied in relation to fluctuations in populations of voles ( Clethrionomys glareolus and Microtus agrestis) . Willow ramets were collected from four different areas in the coastal part of Sweden and Finland at the Bothnian Bay. In each area we selected one mainland and one island locality. The ramets, as well as the scars left by bark-eating voles on the ramets, were aged. We found in general a high correlation between ramet ages and peaks in vole cycles (based on frequencies of scars). From a sample of 79 willow clones where all ramets were aged, more than half of the ramets were produced the summer following a vole peak. Field surveys of seedling survival showed that successful establishment is mainly confined to disturbed ground (vole run-ways, etc.) in connection with vole peak years. It is concluded that the age structure both at the genet and the ramet level in boreal willow populations are strongly influenced by the fluctuations in vole populations. The consequences of vole herbivory are manifold, e.g. periodic damage of willows may delay senescence of individual genets and delay the rate of succession due to increased opportunities for willow recruitment.
A critical narrative inquiry to understand relapse among Filipino methamphetamine polydrug users in low-income communities

Abstract In the Philippines where an ongoing national drug campaign is implemented, continuous recovery of drug users is compromised especially those coming from low-income communities. However, studies that explore drug relapse and recovery issues in such communities are still scant. As an exemplar case, a critical narrative inquiry was performed to analyze accounts of 17 Filipino male low-income methamphetamine polydrug users and their experiences of repeated drug relapse. Findings show three overarching narratives namely: drug relapse as being taken by the body, drug use as mode of living and thriving in communities, and as a cyclic narrative of rehabilitation and community reintegration. Implications on understanding the interplay between personal agency and broader risk environments are discussed in light of existing rehabilitation and treatment modalities in drug recovery targeting low-income communities.
Avaliação do Impacto Emocional e de Desempenho em Jogos Sérios para o Desenvolvimento do Pensamento Computacional na Educação Inclusiva

Serious games can improve teaching-learning processes by attracting,inspiring and motivating student interest. Through the applicationof educational games, students develop skills that encompasscomputational thinking. Such skills enable students to solve realproblems. Thus, this article aims to evaluate the impact of the insertionof serious games for the teaching of basic concepts aboutcomputational thinking, analyzing and correlating the emotionaland performance aspects that contribute to a better interactionamong students of inclusive education. For this purpose, two seriousgames were selected and nineteen students with special needswere recruited, proposing to perform a set of tasks in each game,measuring the emotional aspects through the Geneva Emotions andperformance wheel. The results demonstrate a strong correlationbetween positive emotions and good student performance, thuslowering the barriers to interaction, significantly impacting theaccomplishment of tasks and gameplay of games.
King size or all size: Proposing a typology of amplification translation technique for children picturebook translation

The necessity for a children’s picturebook to generate a proairetic decoding by the children influences translators to deliver the messages of the source text as explicit as possible. This condition leads the translators to implement amplifications aimed at detailing particular information. Though a proairetic reading is achieved through amplification, negative impacts follow the implementation. This qualitative experiential study involves nine children picturebook translators. Exchanging insights and translated texts in a focused group discussion (FGD) comprising of English to Indonesian and English to Javanese children picturebook translators, we found that a typology of amplification technique constructed specifically for children picturebook translation is required to provide a guideline for the translators when forced to apply amplification. The result of the translation data, supported by FGD, indicates that amplification is classifiable into three function-based types namely naturalizing, synchronizing, and stylizing amplifications. These amplifications, when applied, generate four impacts namely congruity losses, effect rendering, reading level deviation, and deviation on the purposes of the children’s picturebooks. These impacts deal with verbosity and thus requiring a further concern on verbosity level acceptance.
Estimation of Average Annual Daily Bicycle Counts using Crowdsourced Strava Data

Traffic volumes are fundamental for evaluating transportation systems, regardless of travel mode. A lack of counts for non-motorized modes poses a challenge for practitioners developing and managing multimodal transportation facilities, whether they want to evaluate transportation safety or the potential need for infrastructure changes, or to answer other questions about how and where people bicycle and walk. In recent years, researchers and practitioners alike have been using crowdsourced data to supplement the non-motorized counts. As such, several methods and tools have been developed. The objective of this paper is to take advantage of new data sources that provide a limited and biased sample of trips and combine them with traditional counts to develop a practical tool for estimating annual average daily bicycle (AADB) counts. This study developed a direct-demand model for estimating AADB in Texas. Data from 100 stations, installed in 12 cities across the state, was used together with the crowdsourced Strava, roadway inventory, and American Community Survey data to develop the count model for estimating AADB. The results indicate that crowdsourced Strava data is an acceptable predictor of bicycle counts, and when used with the roadway functional class and number of high-income households in a block group, can provide quite an accurate AADB estimate (29% prediction error).
A MATHEMATICAL MODEL FOR TREATMENT OF PAPILLARY THYROID CANCER USING THE ALLEE EFFECT

The incidence of thyroid cancer is rising all over the world, and the papillary subtype (PTC) is the primary factor for this increase. The presence of thyroid tumors is commonly associated with increased levels of cytokines, such as interleukin 6 (IL-6). Considering PTC patients treated with thyroidectomy and radioactive iodine [Formula: see text]I (RAI), we propose an ordinary differential system using four variables: the RAI activity, the number of cancer cells and the serum concentrations of IL-6 and thyroglobulin (Tg). Our objective is to study the efficacy of different therapeutic doses of RAI in the treatment of thyroid cancer. The Allee effect is taken into account when modeling cancer cells growth under the influence of IL-6. From the results obtained, the main factors and conditions correlated with successful treatment, such as the RAI activity used and the tumor response are addressed. The detection of minimal doses of RAI that can cause tumor extinction is performed, though this has also meant longer periods for tumor cell elimination. The critical number of tumor cells due to the Allee effect is analyzed and linked to the immune system or biological factors that can slow the progression of the tumor but are insufficient after thyroid resection surgery.
Isatin Endowed Metal Chelates as Antibacterial and Antifungal Agents

River ABSTRACT A new series of 5-chloroindoline-2,3-dione (isatin) derived ligands (L1)-(L4) were prepared by reacting isatin with various diamines such as ethane-1,2-diamine, propane-1,3-diamine, butane-1,4-diamine, and benzene-1,2-diamine in an equimolar ratio to give 3-[(2-aminoethyl)imino]-5-chloro-1,3-dihydro-2H-indol-2-one (L1), 3-[(3-aminopropyl) imino]-5-chloro-1,3-dihydro-2H-indol-2-one (L2), 3-[(4-aminobutyl)imino]-5-chloro-1,3-dihydro-2H-indol-2-one (L3) and 3-[(2-aminophenyl)imino]-5-chloro-1,3-dihydro-2H-indol-2-one (L4). All ligands acted as tridentate possessing three active sites, isatin-O, azomethine-N, and amino-N for binding with the metal atoms. The structures of the isatin based Schiff bases were elucidated through their spectral (infrared, ultraviolet, nuclear magnetic resonance, and mass spectra), physical (melting point and solubility) and analytical (C, N, H %) data. The prepared ligands were reacted with Co(II), Ni(II), Cu(II), and Zn(II) transition metals in 1:2 molar ratio (metal:ligand) to form their complexes. IR, UV, NMR, conductance, magnetic moment, and elemental analysis was used to characterize the metal complexes. Metals based isatins were evaluated for their in-vitro antimicrobial properties against selected fungal and bacterial species. The anti-bacterial and anti-fungal results showed the metal chelates to be more biologically active than their parent uncomplexed ligands.
Trichodinids (Ciliophora) of Corydoras paleatus (Siluriformes) and Jenynsia multidentata (Cyprinodontiformes) from Argentina, with description of Trichodina corydori n. sp. and Trichodina jenynsii n. sp.

During surveys of parasites of the pepper cory Corydoras paleatus Jenyns, 1842 and sided-livebearer Jenynsia multidentata Jenyns, 1842 from Samborombon River, Argentina, Trichodina corydori n. sp. , Trichodina cribbi Dove and O’Donoghue, 2005 and T. jenynsii n. sp. were morphologically studied. Taxonomic and morphometric data for these trichodinids based on dry silver nitrate-impregnated specimens are presented. Trichodina corydori is characterized by a prominent blade apophysis, the section connecting the blade and central part is short, and the adoral ciliary spiral makes a turn of 370–380°. Trichodina jenynsii is characterized by curved blades and prominently-shaped denticle rays that are characteristically extremely long, tapering to thin sharp points in adult specimens. This study is the first formal report of these trichodinids from South America, and the description of two new species.
Population dynamics of the tomato leaf miner Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) in Tunisia natural conditions

Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) is a key pest of tomato crops in Tunisia causing heavy losses to its production. The population dynamics of this pest was surveyed during spring-summer tomato growing season in Zaghouan and Nabeul provinces between 2014 and 2016. T. absoluta was monitored using two sex pheromone water traps. Tomato leaves were harvested and inspected weekly in order to determine the number of generation accomplish by each alive instar (eggs, larvae and pupae). Mines with and without larvae are also counted. Results showed that this pest was able to achieve 4-5 flight peaks. Three generations of eggs and larvae were recorded with a significant preference to laid eggs in the underside of leaves. High correlations were found between traps catches, eggs laid, active and total mines. Obtained data may help Tunisian farmers to detect early infestations, therefore to establish and to apply efficient control methods.
Improved path flux analysis mechanism reduction method for high and low temperature oxidation of hydrocarbon fuels

Due to the increasing attention of low temperature combustion, more precise and convenient low temperature chemical reaction mechanism is needed in the combustion reaction flow modelling. However, most of the conventional mechanism reduction methods are difficult to deal with the low temperature mechanism. In order to reduce the low temperature combustion mechanisms of hydrocarbon fuel efficiently, an improved path flux analysis mechanism reduction method (PFA) is proposed. In the improved reduction method, in addition to considering the coupling with the preselected components, the influence on the heat release should be fully considered. By comparing the reaction flow of the method with the traditional PFA method in the process of homogeneous ignition and flame propagation of heptane and octane, the accuracy and efficiency of the improved method (PFAHRR) are fully confirmed. The PFAHRR method is used in the mechanism reduction software ChemRC, which greatly improves the accuracy and efficiency of the software. This new method and tool provide an effective means for the analysis of combustion characteristics of hydrocarbon fuels, especially low temperature kinetics.
Complejo respiratorio bovino: evidencia de circulación viral múltiple en un establecimiento de cría

El complejo respiratorio bovino (CRB) es una de las principales causas de perdidas productivas en rodeos de cria, tambo y engorde a corral. Los agentes infecciosos involucrados incluyen virus, bacterias y micoplasmas. Dentro de los agentes virales se encuentran el virus respiratorio sincicial bovino (bRSV), virus parainfluenza 3 bovino (BPIV3), herpesvirus bovino tipo 1 (BoHV1) y el virus de la diarrea viral bovina (BVDV). El objetivo de este trabajo fue evaluar la circulacion de los virus asociados al CRB en un rodeo de cria, durante el periodo post destete, mediante un estudio serologico longitudinal. En forma complementaria, se describieron y compararon los hallazgos clinicos y hematologicos. Se seleccionaron 32 animales de 5 a 7 meses de edad, sin vacunacion previa, y se evaluo diariamente la presencia de signos clinicos compatibles con CRB. Se extrajeron muestras de sangre los dias 0 (destete), +14 y +25 (momento en que culmino el ensayo). No se detectaron animales con manifestacion clinica de CRB y los parametros hematologicos se encontraron dentro del rango de referencia. Al inicio de la expereriencia, ningun animal presentaba anticuerpos (Ac) especificos para bRSV, mientras que para el resto de los agentes virales, el porcentaje de animales seropositivos fue variable: 53% (BVDV1a), 31% (BPIV3), 25% (BVDV2) y 13% (BoHV1). Al dia +25 los porcentajes de seropositivos fueron los siguientes: 47% (BVDV1a), 50% (BPIV3), 19% (BVDV2), 25% (BoHV1) y 81% (bSRV). Los porcentajes de seroconversion para bRSV, BPIV3, BVDV1a y BoHV1 fueron 34%, 25%, 16% y 13%, respectivamente. Ademas, el 66 % de los animales seroconvirtio a uno o mas virus. Para BVDV2 y BVDV1b no se observo seroconversion. Estos resultados evidencian la circulacion, e incluso en algunos casos la coinfeccion, de los agentes virales involucrados en el CRB en el periodo post destete. Resulta importante la realizacion de estudios virologicos complementarios que permitan identificar y caracterizar las cepas circulantes en esta etapa productiva, principalmente en relacion a bSRV y PI3, virus de los que se posee escasa informacion en nuestro medio.
Development of the solar roof tile with internal cooling

This paper deals with the development of the roof tile with the integrated solar panel. This panel is cooled down with respect to maximizing of the efficiency. Dimensions of the tile are according generally used roof tile. Plastic solar tile can replace the regular one. The design of the tile was validated by usage of thermal simulations and flow simulations in NX Nastran software. These FEM solutions were validated by the measurement on the prototype. The output of this research is prototype from plastic material. This material was selected because of the fast and cheap production.
Analysis of labels of medicinal teas from formal trade and notes on the lack of concern for botanical nomenclature

This work analyzed the labels of medicinal teas from formal trade, according to the specific legislation. Thirty samples of herbal drugs included in the Form of Phytotherapeutics of the Brazilian Pharmacopeia were photographed in commercial establishments in Rio de Janeiro state, Brazil, and analyzed according to the Resolution of Anvisa RDC 26/2014 and the Form. Information related to the botanical nomenclature, plant part, guidelines for preparation, warnings, claims, and orientations for use was inconsistent with the official standards in most samples, and 77% were marketed as food products, although the studied species are not regulated for the commercialization in the food area. The consumption of herbal products in disagreement with the official recommendations may cause toxic effects or lack of the expected benefits. The irregularities identified suggest the absence or failure in quality control and a lack of concern for the scientific botanical nomenclature, exposing the public health to risks.
Solution structure properties and (dys)function of phospholipase Cγ

Phosphatidylinositol phospholipase Cγ (PLCγ) is an intracellular membrane-associated second messenger signalling protein, which is activated by tyrosine kinases such as fibroblast growth factor receptor 1 (FGFR1). PLCγ contains the pseudocyclic γ-specific array (γSA), in which a SH2 domain pair (tandem-SH2), a SH3 domain, and a split-PH domain are connected by linker segments, effectively within a loop that is an insert in the catalytic domain. Activated FGFR1 binding to the nSH2 domain leads to phosphorylation of Y783, a residue in the γSA cSH2-SH3 linker. This modification terminates PLCγ autoinhibition by the cSH2 domain and reduces nSH2 affinity to FGFR1. This work has focused on the effect of Y783 phosphorylation on the tandem-SH2 solution structure and on PLCγ-FGFR dissociation. This work also aims to shed light on the mechanistic basis of activating mutations in PLCγ relevant for cancer and autoimmune disease. Molecular dynamics simulations followed by principal component analysis and contact analysis suggest a substantial solution structure difference between phospho- and non-phospho-tandem-SH2, the crystal structures of which are similar. After NMR backbone resonance assignment for both forms of tandem-SH2, chemical shift perturbation analyses, relaxation data analysis, residual dipolar coupling and SAXS experiments suggest that phosphorylation reduces the inter-SH2-domain flexibility, but does not lead to a change of relative SH2 domain orientation. The cSH2-Y783 linker is mechanistically important for allosterically communicating Y783 phosphorylation to the nSH2-cSH2 junction, which had been predicted by MD simulations. The C-terminus, along with the cSH2-Y783 linker, might thereby play an important role in an allosteric mechanism leading to FGFR1 kinase release. Activating PLCγ mutations were characterized in terms of their effects on autoinhibition, on the ability of Y783 to be phosphorylated, on and protein stability and on relative SH2 domain orientation. The PLCγ1 mutation R707Q was found to act by destabilizing the cSH2 domain and thereby promote release of PLCγ autoinhibition. The PLCγ1 mutation R687W leads to a complex modulation of the allosteric pathways in cSH2; it was also observed to be phosphorylated faster in a custom-made real-time in-NMR-tube FGFR kinase assay. An NMR analysis in the context of the γSA became feasible after transfer of backbone resonance assignments from the individual domains.
Optimization of the Enzymatic Hydrolysis of Soy Protein Isolate by Alcalase and Trypsin

1Department of Food Science and Technology, Sabzevar Branch, Islamic Azad University, Sabzevar, Iran. 2Department of Food Science and Technology, Sabzevar Branch, Islamic Azad University, Sabzevar, Iran. 3Agricultural Research Education and Extension Organization (AREEO), Iranian Fisheries Science Research Institute (IFSRI), Caspian Sea Ecology Research Center, Sari, Iran. 4Department of Fisheries, Ghaemshar Branch, Islamic Azad University, Ghaemshar, Iran.
Discrimination Power Assessment of STR Genotyping in Parentage Investigation

OBJECTIVE Nowadays, the application of DNA-typing in laboratory medicine is increasing rapidly for paternity/maternity disputes. The goal of this study was to evaluate the use of polymorphic microsatellite marker DNA analysis and to establish this analysis as the method of choice for parentage investigations. SUBJECTS AND METHODS Among 708 civil parentage tests addressed to our Laboratory previously examined for HLA class I (-A*,-B*,-Cw*), and class II (-DRB1*,-DQB1*,-DPB1*) alleles using PCR-SSOP and/or PCR-SSP methodologies, a cohort of 50 cases (137 individuals) of disputed parentage was selected. In these cases DNA-typing was generated from co-amplification of 15 autosomal STR DNA markers (D3S1358, HUMTH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, HUMCSF1PO, Penta D, HUMvWA, D8S1179, HUMTPOX, HUMFGA and the sex determining Amelogenin marker HUMAMEL), using fragment analysis methodology. RESULTS The evaluation of the results showed that 15 out of 50 cases, were sufficient for exclusion of fatherhood by both approaches (HLA and STRs). In all remaining 35 non-excluded cases, the PI value using HLA genotyping ranged from 76 to 6,452,794, whereas using aSTR genotyping ranged from 15,173 to 9.2 x 10 10 . In one non-excluded motherless case the alleged father showed one genetic discrepancy with the child at D21S11 locus, due to a mutation event. CONCLUSION The use of DNA-typing with 15 aSTR loci for parentage testing provides an accurate and high-sensitivity method which is simpler to perform and more rapid than an accepted standard technology, such as HLA genotyping. The analysis of aSTR loci offers a highly discriminating test suitable for trio paternity testing, increasing the W rate in comparison to HLA genotyping. Nevertheless, when a mutation event occurs in motherless cases, combination of HLA and STR polymorphisms offers high level of information, and also diminishes the possibility of false exclusion due to aSTRs mutations.