Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevention of Cesarean Delivery Surgical Site Infections.

Importance Surgical site infection (SSI) is a common complication of cesarean delivery. Seen in up to 12% of cesarean deliveries, it is a major cause of prolonged hospital stay and a burden to the healthcare system. Interventions and techniques must be identified to decrease the risk of cesarean delivery SSIs. Objective We review the categories of SSI, current studies that have focused on various interventions to decrease SSI, and preoperative, intraoperative, and postoperative recommendations for cesarean delivery SSI prevention. Evidence Acquisition A thorough search of PubMed for all current literature was performed. Various surgical interventions and techniques were reviewed. We included studies that looked at preoperative, intraoperative, and postoperative interventions for SSI prevention. Results We have summarized several surgical interventions and techniques as well as current consensus statements to aid the practitioner in preventing SSIs after cesarean delivery. Conclusions and Relevance Upon analysis of current data and consensus statements pertaining to cesarean deliveries, there are certain preoperative, intraoperative, and postoperative interventions and techniques that can be recommended to decrease the risk of cesarean delivery SSI.
Fossils with Feathers and Philosophy of Science

Abstract The last half century of paleornithological research has transformed the way that biologists perceive the evolutionary history of birds. This transformation has been driven, since 1969, by a series of exciting fossil discoveries combined with intense scientific debate over how best to interpret these discoveries. Ideally, as evidence accrues and results accumulate, interpretive scientific agreement forms. But this has not entirely happened in the debate over avian origins: the accumulation of scientific evidence and analyses has had some effect, but not a conclusive one, in terms of resolving the question of avian origins. Although the majority of biologists have come to accept that birds are dinosaurs, there is lingering and, in some quarters, strident opposition to this view. In order to both understand the ongoing disagreement about avian origins and generate a prediction about the future of the debate, here we use a revised model of scientific practice to assess the current and historical state of play surrounding the topic of bird evolutionary origins. Many scientists are familiar with the metascientific scholars Sir Karl Popper and Thomas Kuhn, and these are the primary figures that have been appealed to so far, in prior attempts to assess the dispute. But we demonstrate that a variation of Imre Lakatos’s model of progressive versus degenerative research programmes provides a novel and productive assessment of the debate. We establish that a refurbished Lakatosian account both explains the intractability of the dispute and predicts a likely outcome for the debate about avian origins. In short, here, we offer a metascientific tool for rationally assessing competing theories—one that allows researchers involved in seemingly intractable scientific disputes to advance their debates.
Areas Suspicious for Prostate Cancer : MR – guided Biopsy in Patients with at Least One Transrectal US-guided Biopsy with a Negative Finding — Multiparametric MR Imaging for Detection and Biopsy Planning 1

Tobias Franiel , MD Carsten Stephan , MD , PhD Andreas Erbersdobler , MD , PhD Ekkehart Dietz , MS , PhD Andreas Maxeiner Nina Hell Alexander Huppertz , MD Kurt Miller , MD , PhD Ralph Strecker , MS , PhD Bernd Hamm , MD , PhD Purpose: To prospectively investigate the incremental value of multiparametric magnetic resonance (MR) imaging compared with standard T2-weighted imaging for biopsy planning.
The effect of polyphenols and vitamin E on the antioxidant status and meat quality of broiler chickens exposed to high temperature

ABSTRACT The aim of this study was to determine the effect of a polyphenol product (PP) (Proviox) and vitamin E on the antioxidant status and meat quality of broiler chickens exposed to high temperature. The experimental materials comprised 120 ROSS 308 broilers (6 treatments, 10 replications, 2 birds per replication). Dietary supplementation with vitamin E and PP was applied in the following experimental design: group I (negative control) – without supplementation; group II (positive control) – without supplementation; group III – supplementation with 100 mg vitamin E/kg; group IV – 200 mg vitamin E/kg; group V – 100 mg vitamin E/kg and 100 mg PP/kg; group VI – 200 mg PP/kg. In groups II–VI, broiler chickens aged 21–35 d were exposed to increased temperature (34°C for 10 h daily). In chickens exposed to high temperature, dietary supplementation with antioxidants, mostly PP, improved growth performance parameters, including body weight, body weight gain and feed intake until 28 d of age. Vitamin E added to broiler chicken diets at 200 mg/kg and vitamin E combined with PP was most effective in improving the total antioxidant status of birds, enhancing blood antioxidant enzyme activities and increasing vitamin E concentrations in the liver and breast muscles. Broilers fed diets supplemented with 200 mg/kg of vitamin E alone and vitamin E in combination with PP were characterised by a higher percentage content of breast muscles in the carcass. Dietary supplementation with antioxidants improved the water-holding capacity of meat, reduced natural drip loss and increased the crude ash content of meat. The breast muscles of chickens fed diets supplemented with PP had a lower contribution of yellowness. The breast muscles of chickens receiving diets with 100 mg vitamin E/kg(group III) and diets supplemented with PP (groups V and VI) were characterised by the highest concentrations of polyunsaturated fatty acids. The PP can be a valuable component of diets for broiler chickens exposed to high temperature.
Statins Perturb Gβγ Signaling and Cell Behavior in a Gγ Subtype Dependent Manner

Guanine nucleotide-binding proteins (G proteins) facilitate the transduction of external signals to the cell interior, regulate most eukaryotic signaling, and thus have become crucial disease drivers. G proteins largely function at the inner leaflet of the plasma membrane (PM) using covalently attached lipid anchors. Both small monomeric and heterotrimeric G proteins are primarily prenylated, either with a 15-carbon farnesyl or a 20-carbon geranylgeranyl polyunsaturated lipid. The mevalonate [3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase] pathway synthesizes lipids for G-protein prenylation. It is also the source of the precursor lipids for many biomolecules, including cholesterol. Consequently, the rate-limiting enzymes of the mevalonate pathway are major targets for cholesterol-lowering medications and anticancer drug development. Although prenylated G protein γ (Gγ) is essential for G protein–coupled receptor (GPCR)-mediated signaling, how mevalonate pathway inhibitors, statins, influence subcellular distribution of Gβγ dimer and Gαβγ heterotrimer, as well as their signaling upon GPCR activation, is poorly understood. The present study shows that clinically used statins not only significantly disrupt PM localization of Gβγ but also perturb GPCR-G protein signaling and associated cell behaviors. The results also demonstrate that the efficiency of prenylation inhibition by statins is Gγ subtype-dependent and is more effective toward farnesylated Gγ types. Since Gγ is required for Gβγ signaling and shows a cell- and tissue-specific subtype distribution, the present study can help understand the mechanisms underlying clinical outcomes of statin use in patients. This work also reveals the potential of statins as clinically usable drugs to control selected GPCR-G protein signaling.
Another Notch in the Genetic Puzzle of Tetralogy of Fallot.

Congenital heart disease (CHD) is the most common type of birth defect, affecting ≈1% of live births, and with the inclusion of bicuspid aortic valve, the prevalence is estimated to be 2% to 3%. Remarkable improvements in the medical and surgical management of individuals affected by CHD have resulted in an ever-growing population of adult CHD survivors. As these children reach reproductive age, questions arise regarding the risk of having an infant with CHD as prior epidemiological studies have consistently demonstrated an increased recurrence risk supporting genetic contributors. Recently, a greater understanding of the complex genetic architecture that underlies CHD has been achieved, based on molecular discoveries defining cardiovascular developmental pathways and new genomic technologies that allow for detailed analysis of the human genome. The first successes were achieved using positional cloning approaches studying inherited forms of syndromic and nonsyndromic CHD, but the increasing use of genome-wide approaches is uncovering novel submicroscopic chromosomal abnormalities and pathogenic sequence variants associated with CHD. Currently, it is estimated that a genetic cause can be identified in nearly 30% of CHD cases.
Semisupervised Discriminant Multimanifold Analysis for Action Recognition

Although recent semisupervised approaches have proven their effectiveness when there are limited training data, they assume that the samples from different actions lie on a single data manifold in the feature space and try to uncover a common subspace for all samples. However, this assumption ignores the intraclass compactness and the interclass separability simultaneously. We believe that human actions should occupy multimanifold subspace and, therefore, model the samples of the same action as the same manifold and those of different actions as different manifolds. In order to obtain the optimum subspace projection matrix, the current approaches may be mathematically imprecise owe to the badly scaled matrix and improper convergence. To address these issues in unconstrained convex optimization, we introduce a nontrivial spectral projected gradient method and Karush–Kuhn–Tucker conditions without matrix inversion. Through maximizing the separability between different classes by using labeled data points and estimating the intrinsic geometric structure of the data distributions by exploring unlabeled data points, the proposed algorithm can learn global and local consistency and boost the recognition performance. Extensive experiments conducted on the realistic video data sets, including JHMDB, HMDB51, UCF50, and UCF101, have demonstrated that our algorithm outperforms the compared algorithms, including deep learning approach when there are only a few labeled samples.
Bridging the cultural divide? Exploring school pupils’ perceptions of medicine

Literature published around a decade ago demonstrated that UK individuals from non‐traditional groups may not consider, or aspire to, medicine because of sociocultural barriers and instead may perceive medicine as ‘not for the likes of me’. Since this time, the UK higher education landscape has undergone significant change, with an increased emphasis on student choice and widening access (WA) initiatives. Consequently, the present study looks anew at the perceptions of medicine held by school pupils from non‐traditional backgrounds to assess whether sociocultural factors remain a major barrier to medicine.
A comparison of the effects of mirror therapy and phantom exercises on phantom limb pain

Background/aim Although mirror therapy (MT) and phantom exercises (PE) have been shown to reduce pain, the efficacy of these methods in terms of pain, quality of life (QoL), and psychological status (PS) has not been investigated and compared to date. The aim of this study was to determine whether there is any difference between MT and PE in the treatment of phantom limb pain (PLP). Materials and methods Forty unilateral transtibial amputees (aged 18–45 years) participated in this study. The subjects were randomly divided into ‘MT group’ and ‘PE group’. QoL was assessed using Short-Form 36 (SF-36), psychological status using the Beck depression inventory (BDI), and pain intensity using a visual analog scale (VAS), before and at the end of the program, and on the 3rd and 6th months thereafter. Results All assessments for all parameters improved significantly in both groups (P < 0.05). Comparison of the two groups revealed a significant difference in changes for VAS and BDI in all measurements, and in pre- and posttreatment scores for all SF-36 parameters (except for Role-Emotional) in favor of the MT group (P < 0.05). Conclusion While pain intensity decreased and QoL and PS improved in both the MT and PE groups, these improvements were greater in the MT group.
Raspberries Improve Postprandial Glucose and Acute and Chronic Inflammation in Adults with Type 2 Diabetes

Background: Postprandial metabolic impairments in diabetes have been shown to play an important role in vascular complications. Dietary polyphenols and other bioactive compounds in berries have been shown to improve postprandial hyperglycemia and related metabolic impairments, but few clinical studies have been reported in diabetes. Objective: To examine the effects of daily dietary raspberries on postprandial and 4-week fasting glucose, lipids and biomarkers of inflammation in obese adults with type 2 diabetes. Design: This was a randomized crossover study with 2 different phases: a “postprandial phase” of acute raspberry supplementation (2 separate days at least 1 week apart), followed by a 1-week washout phase and then a 10-week “diet supplement phase”, with and without raspberry supplementation periods of 4 weeks each, separated by 2-week washout phase. Results: The postprandial phase revealed significantly lower levels of serum glucose at 2 and 4 h postprandial after raspberry versus control phase. In addition, among the serum biomarkers of inflammation, interleukin (IL)-6 and high-sensitivity tumor necrosis factor alpha (hsTNF-α) were also lower at 4 h postprandial following raspberry versus control meal (all p < 0.05). Finally, postprandial serum triglycerides showed a decreasing trend at 4 h in the raspberry versus control phase. Four-week daily raspberry supplementation continued to show a significant lowering effects on IL-6 and hsTNF-α versus control phase (all p < 0.05); systolic blood pressure revealed a decreasing trend after 4-week of raspberry supplementation. No effects were noted on fasting glucose and lipids, C-reactive protein and arterial elasticity. Conclusions: Thus, dietary raspberries, which are low in calories and high in polyphenols and other nutrients may lower postprandial hyperglycemia and inflammation, and in general exert selected anti-inflammatory effects in adults with diabetes. These findings deserve further investigation.
Chronic Staphylococcus aureus lung infection correlates with proteogenomic and metabolic adaptations leading to an increased intracellular persistence

Background Chronic lung infection of cystic fibrosis (CF) patients by Staphylococcus aureus is a well-established epidemiological fact. Indeed, S. aureus is the most commonly identified pathogen in the lungs of CF patients. Strikingly the molecular mechanisms underlying S. aureus persistency are not understood. Methods We selected pairs of sequential S. aureus isolates from 3 patients with CF and from one patient with non-CF chronic lung disease. We used a combination of genomic, proteomic and metabolomic approaches with functional assays for in-depth characterization of S. aureus long-term persistence. Results For the first time, we show that late S. aureus isolates from CF patients have an increased ability for intracellular survival in CFBE-F508del cells compared to ancestral early isolates. Importantly, the increased ability to persist intracellularly was confirmed for S. aureus isolates within the own patient F508del epithelial cells. An increased ability to form biofilm was also demonstrated. Furthermore, we identified the underlying genetic modifications inducing altered protein expression profiles and notable metabolic changes. These modifications affect several metabolic pathways and virulence regulators that could constitute therapeutic targets. Conclusions Our results strongly suggest that the intracellular environment might constitute an important niche of persistence and relapse necessitating adapted antibiotic treatments. Summary S. aureus persists for years in the lungs of patients with cystic fibrosis despite antibiotic therapies. We demonstrate that S. aureus adaptation leads to increased intracellular persistence suggesting a key role for intracellular niche during S. aureus chronic lung infection.
Toward Voice Query Clarification

Query suggestions are a standard means to clarify the intent of underspecified queries. In a voice-based search setting, the compilation of query suggestions is not straightforward, and user-centric research targeting query underspecification is lacking so far. Our paper analyses a specific type of ambiguous voice queries and studies the impact of various kinds of voice query clarifications offered by the system and its impact on user satisfaction. We conduct a user study that measures the satisfaction for clarifications that are explicitly invoked and presented by seven different methods. Our findings include that (1) user experience depends on language proficiency levels, (2) users are not dissatisfied when prompted for clarifications (in fact, enjoy it sometimes), and (3) the most effective way of query clarification depends on the number and lengths of the possible answers.
Glutamate receptor delocalization in postsynaptic membrane and reduced hippocampal synaptic plasticity in the early stage of Alzheimer’s disease

Mounting evidence suggests that synaptic plasticity provides the cellular biological basis of learning and memory, and plasticity deficits play a key role in dementia caused by Alzheimer’s disease. However, the mechanisms by which synaptic dysfunction contributes to the pathogenesis of Alzheimer’s disease remain unclear. In the present study, Alzheimer’s disease transgenic mice were used to determine the relationship between decreased hippocampal synaptic plasticity and pathological changes and cognitive-behavioral deterioration, as well as possible mechanisms underlying decreased synaptic plasticity in the early stages of Alzheimer’s disease-like diseases. APP/PS1 double transgenic (5XFAD; Jackson Laboratory) mice and their littermates (wild-type, controls) were used in this study. Additional 6-week-old and 10-week-old 5XFAD mice and wild-type mice were used for electrophysiological recording of hippocampal dentate gyrus. For 10-week-old 5XFAD mice and wild-type mice, the left hippocampus was used for electrophysiological recording, and the right hippocampus was used for biochemical experiments or immunohistochemical staining to observe synaptophysin levels and amyloid beta deposition levels. The results revealed that, compared with wild-type mice, 6-week-old 5XFAD mice exhibited unaltered long-term potentiation in the hippocampal dentate gyrus. Another set of 5XFAD mice began to show attenuation at the age of 10 weeks, and a large quantity of amyloid beta protein was accumulated in hippocampal cells. The location of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor and N-methyl-D-aspartic acid receptor subunits in synaptosomes was decreased. These findings indicate that the delocalization of postsynaptic glutamate receptors and an associated decline in synaptic plasticity may be key mechanisms in the early onset of Alzheimer’s disease. The use and care of animals were in strict accordance with the ethical standards of the Animal Ethics Committee of Capital Medical University, China on December 17, 2015 (approval No. AEEI-2015-182).
Multipole Radiations from Large Gold Nanospheres Excited by Evanescent Wave

We proposed the use of the evanescent wave generated in a total internal reflection configuration to excite large gold nanospheres and investigated the radiations of the high-order plasmon modes supported in gold nanospheres. It was revealed that the evanescent wave excitation is equivalent to the excitation by using both the incident and reflected light, offering us the opportunity to control the orientation of the electric field used to excite nanoparticles. In addition, it was found that the scattering light intensity is greatly enhanced and the background noise is considerably suppressed, making it possible to detect the radiations from high-order plasmon modes. Moreover, the influence of the mirror images on the scattering induced by a metal substrate is eliminated as compared with the surface plasmon polariton excitation. By exciting a gold nanosphere with s-polarized light and detecting the scattering light with a p-polarized analyzer, we were able to reveal the radiation from the electric quadrupole mode of the gold nanosphere in both the spatial and the frequency domains. Our findings are important for characterizing the radiations from the high-order modes of large nanoparticles and useful for designing nanoscale photonic devices.
Idiopathic syringomyelia: phase-contrast MR of cerebrospinal fluid flow dynamics at level of foramen magnum.

PURPOSE To measure cerebrospinal fluid (CSF) flow velocities in the foramen magnum in patients with idiopathic syringomyelia (IS). MATERIALS AND METHODS Patient consent for this retrospective study was waived by the institutional review board within the guidelines of HIPAA. The authors reviewed the medical records of a neurosurgery specialty clinic to identify patients with IS-that is, syringomyelia without evidence of Chiari malformation, tumor, or substantial spine trauma. Patients without syringomyelia or Chiari malformation identified from the review served as control subjects. The data of patients and control subjects who had undergone phase-contrast magnetic resonance (MR) imaging were included in the study. MR flow images were inspected for evidence of synchronous bidirectional CSF flow and heterogeneous spatial and temporal flow patterns. Peak CSF flow velocities in the IS and control groups were calculated, and differences were tested for statistical significance by using the Wilcoxon rank sum test. RESULTS Eight patients who met the criteria for IS and six who met the criteria to serve as control subjects were identified. The phase-contrast MR images obtained in five of the eight patients with IS and in none of the control subjects depicted synchronous bidirectional flow and/or large flow jets. Mean peak systolic (caudal) CSF flow velocities were 6.7 cm/sec in the IS group and 3.6 cm/sec in the control group; the difference was significant (P < .01). Mean peak diastolic (cephalic) velocities were 3.9 and 3.4 cm/sec in the IS and control groups, respectively; the difference was not significant (P = .36). CONCLUSION Some patients with IS have increased peak systolic CSF flow velocities.