Study on Effect of Anticlostridial Antibiotics Medication and Acidifier Copper Sulfate Mixture in Improvement of Performance against Clostridial Infection in Broiler Chickens

This study was conducted to evaluate different regimen usually used in field for treatment of necrotic enteritis (NE) as bacitracin methylene disalicylate (BMD), amoxycillin (Bioamoxi) and acidifier copper sulphate mixture (Sanifeed NC). Two hundred broiler chicken were divided into eight groups; 25 each. Performance parameters were studied including average weekly body weight, feed conversion rate (FCR), mortalities, postmortem (P.M.) lesions together with liver and intestinal tissue samples for histopathological examination. Results revealed that all control negative chicks and groups received bacitracin methylene disalicylate (bacitracin M.D.), amoxycillin and acidifier copper sulphate mixture from one day old or after challenge shows no mortalities and clinical signs, while those control positive group shows typical clinical signs and mortalities of 70% and 30%; respectively, clinical signs including depression, tendency to huddle and watery dropping. P.M. findings in dead birds were severe inflammation in different parts of small intestine. Regarding average weekly body weight and FCR, it was found that control positive group was the most affected group challenged with Clostridium perfringens (C. perfringens) as average weekly body weight and FCR were 1015 gm and 2.2; respectively by the end of week 4 of age. In case of treatment therapy groups, they showed improved body weight and FCR that were better in groups received treatment therapy start from one day old chicks than those treated post challenge comparatively. Moreover, treated post challenged groups had lower body weight and FCR when compared with control negative group. The group received bacitracin M.D. was the best followed by acidifier copper sulphate mixture then those received amoxycilline in terms of average weekly body weight and FCR. Regarding histopathological changes, it was found that chicken groups treated from one day old are more better than those treated after challenge, on the other hand control positive group are severely affected as intestine of control positive group showed severe necrosis in the mucosa with inflammatory cells infiltration, liver showed severe congestion of the portal veins and vacuolar degeneration of the hepatocytes by 2 day post infection, at 4 day post infection liver of control positive groups showed area of coagulative necrosis infiltrated with inflammatory cells together with congestion of the portal veins and vacuolar degeneration of the hepatocytes. It could be concluded that bacitracin M.D. still standard effective medication against NE and it is preferable to use acidifier as safe alternative for antibiotic medication with long treatment period as it act as growth promotor either by enhancing digestibility or competitive inhibition of colonization of pathogenic bacteria. [Kh. M. Elbayoumi, Eman R. Hassan, Hoda M. Mekky, Zeinab M.S. Amin Girh, M.A.Bosila and Dalia Sedeek. Study on Effect of Anticlostridial Antibiotics Medication and Acidifier Copper Sulfate Mixture in Improvement of Performance against Clostridial Infection in Broiler Chickens. Life Sci J 2014;11(10):838843]. (ISSN:1097-8135). http://www.lifesciencesite. com. 133