Miracle-dz/UniFAR-FTUs huggingface dataset:
Retinopatía del prematuro en el Hospital Nacional Doctor Mario Catarino Rivas de Honduras

Antecedentes: la retinopatia del prematuro es el desarrollo anormal de los vasos de la retina y principal causa de ceguera infantil. El diagnostico precoz y tratamiento oportuno mejoran el pronostico visual. En Latinoamerica viven unos 25,000 ciegos por esta causa. Los principales factores de riesgo son: prematurez, bajo peso al nacer y oxigenoterapia; cuando esta ultima es necesaria, se debe mantener la saturacion de oxigeno por debajo del 93% hasta llegar a la semana 34, para disminuir el riesgo de retinopatia. Objetivo: determinar la frecuencia de retinopatia del prematuro para despertar el interes de las autoridades de salud publica en la prevencion de ceguera por esta causa. Pacientes y Metodos: Estudio descriptivo transversal realizado en el Hospital Nacional Doctor Mario Catarino Rivas en la ciudad deSan Pedro Sula, al norte de Honduras, en donde la natalidad anual supera los 7,000 nacidos vivos, y de estos, 21% nacen con algun grado de prematurez. Resultados: se valoraron 561 lactantes con factores de riesgo para desarrollar retinopatia del prematuro: peso al nacer≤ 1,800 g, edad gestacional ≤ 35 semanas, oxigenoterapia mayor a 8 horas, peso menor a 2,000 g y uno de los siguientes criterios: apoyo ventilatorio, exsanguineo transfusion, fototerapia, transfusion de hemoderivados, maniobras de reanimacion, apgar inferior al normal, embarazos multiples menores de 2,000 g. Encontrandose 242 (43%) afectados y 24 prematuros con ceguera. Conclusion: La mayor sobrevida de ninosprematuros ha aumentado la morbilidad, entre ellas esta la retinopatia del prematuro, que obliga a establecer protocolos para la prevencion, diagnostico y manejo precoz, y asi, evitar la ceguera por esta causa. (AU)
Arthroscopic Revision Rotator Cuff Repair

&NA; Rotator cuff repair leads to good and excellent outcomes in most patients. However, structural failure of the repair occurs in a substantial number of cases and can lead to an unsatisfactory result. Several factors have been implicated, including patientrelated factors (eg, patient age, tear size) and extrinsic factors (eg, surgeon surgical volume, biomechanical failure). Structural failure requires a detailed patient evaluation to elucidate the cause of persistent symptoms. Function can be maintained despite a recurrent tear; therefore, a recurrent tear alone is not an indication for revision repair. The major indication for revision rotator cuff repair is the persistence of clinical symptoms, despite nonsurgical management, in the absence of substantial risk factors for failure. Although the outcome is poorer than after primary repair, satisfactory results have been reported following revision repair of recurrent rotator cuff tears, particularly with arthroscopic techniques.
Entre os domínios da metáfora e da metonímia: um estudo de processos de recategorização

LIMA, Silvana Maria Calixto de. Entre os dominios da metafora e da metonimia: um estudo de processos de recategorizacao. 2009. 205f. – Tese (Doutorado) – Universidade Federal do Ceara, Departamento de Letras Vernaculas, Programa de Pos-graduacao em Linguistica, Fortaleza (CE), 2009.
CONCEPTUAL BASES OF PSYCHIATRY FOR THE PERSON Biological Perspectives on Psychiatry for the Person

The World Psychiatric Association’s Program on Psychiatry for the Person is founded on the World Health Organization’s recognition that health is a state of physical, mental, social, and spiritual well-being, rather than merely the absence of disease (WHO 2001; Mezzich 2007). The WHO definition of health indicates a holistic perspective that a human being cannot be reduced to a material body alone. The whole person is comprised of physical, mental, and spiritual aspects. What may not be obvious to the casual observer, however, is the fact that each of the three aspects of a person has a distinctive biological basis. Different biological systems are involved in the regulation of physical processes (e.g., sexuality, digestion, movement), algorithmic mental processes (e.g., emotional expression, language, logical reasoning), and self-aware creativity (e.g., art, science, spirituality) (Cloninger 2004). Measures of psychological well-being and ill-being have been shown to be associated with numerous biomarkers, adding to a growing literature indicating that the biological correlates of well-being and ill-being are mostly distinct, rather than opposites extremes of common processes (Ryff, Dienberg Love et al. 2006). Any rigorous understanding of the biological perspective on Psychiatry for the Person must recognize the nature of these distinctive biological processes and their implications for promotion of positive health and for the prevention and treatment of ill health.
An Update on the Epidemiology of Pediatric Fractures

Despite public health measures to prevent childhood injuries, the incidence of pediatric fractures is increasing. This fracture incidence is dependent on many demographic factors, the various contributors to bone health, and an individual's risk-taking behavior. Although traditional play activities continue to be the prevalent causes for fractures, there is an evolving array of new sport and recreation activities that carry significant fracture risk. The following review article outlines the developing epidemiology of pediatric fractures by analyzing some of the individual risk factors that influence fracture incidence as well as the variety of activities that are associated with these fractures.
Parameter design for improving injection type hybrid active power filter performance in high power grid

Conventional shunt hybrid active power filter must endure fundamental voltage of power system. To overcome the disadvantage, a new kind shunt hybrid active power filter is researched which is suitable to high power system by installing the active power filter in parallel of fundamental series resonance branch. Based on the summing-up of its electric model, issues in their realization such as sharp rise on dc-link voltage, resonance between filter and grid are analyzed in detail. Multi-objective genetic algorithm is put forward to optimize the parameters of the injection branch in hybrid active power filter. The above parameter design method restrains the resonance and rise on dc-link voltage effectively, and ensure the injection ability of harmonic currents. Simulation and industrial application results have testified that the shunt hybrid active power filter using the parameter designed by the proposed method can achieve high performance in reactive power compensation and harmonic suppression.
Glycemic variability: measurement and utility in clinical medicine and research--one viewpoint.

One cannot control average glucose levels unless one firstreducesglycemicvariability! Thissounds intuitively obvious 1,2 and can also be demonstrated rigorously, mathematically. 3 If the mean glucose level were 100mg/dL but the SD were 40mg/dL, one could predict that there would be an unacceptable incidence of severe hypoglycemia even though the mean glucose is in the euglycemic range. Clinicians must understand glycemic variability both qualitatively and quantitatively and endeavor to reduce that variability before trying to reduce the mean level of blood glucose. This applies to blood glucose as measured by self-monitoring of blood glucose (SMBG), laboratory measurements of venous samples or arterial blood, and interstitial glucose as measured by continuous glucose monitoring (CGM). When titrating a medication such as basal insulin, it is essential to know the between-day (within-subject) variability in fasting plasma glucose to be able to set the target glucose level appropriately so that risk of hypoglycemia is at an acceptable level. Unfortunately, these estimates of glycemic variability are rarely obtained. Glycemic variability also serves as one facet of the quality of glycemic control—another reason to quantify gly
A FINITE ELEMENT METHOD ON COMPOSITE GRIDS BASED ON NITSCHE'S METHOD

In this paper we propose a finite element method for the approximation of second order elliptic problems on composite grids. The method is based on continuous piecewise polynomial approximation on each grid and weak enforcement of the proper continuity at an artificial interface defined by edges (or faces) of one the grids. We prove optimal order a priori and energy type a posteriori error estimates in 2 and 3 space dimensions, and present some numerical examples.
DNA Repair Gene Polymorphisms and Risk of Second Primary Neoplasms and Mortality in Oral Cancer Patients

Objectives/Hypothesis: We tested the hypothesis that polymorphisms in genes involved in DNA repair pathways are associated with the development of second primary neoplasms of the upper aerodigestive tract (UADT), as well as mortality, in patients previously diagnosed with oral squamous cell cancer (OSCC).
Fabrication and characterization of wafer-level deep TSV arrays

Three Dimensional (3D) integration, based on through silicon vias (TSV), has the potential to become a key enabling technology for many applications. TSVs are commonly categorized according to their aspect ratio and diameter. An equally important parameter of the TSV, usually omitted, is their depth. This paper discusses the fabrication process, characterization and detailed failure analysis of deep Cu TSVs, with high aspect ratio. For the proposed process, TSVs are etched on a 380μm thick wafer using standard deep reactive ion etching (DRIE). The electroplating is performed in two steps, the first step seals off one side of the TSV using super conformal chemistry, Dow chemical Intervia™ 8520 bath, and the second step uses the now partially filled via as a seed layer for a bottom up technique, bath Intervia™ 8510 or Intervia™ 8520 Dow Chemical. After the electroplating, a chemical-mechanical polishing (CMP) step is used to planarize the wafer, and double-sided metal sputtering and photolithography are performed to connect the TSVs in a daisy chain. A conventional bonding technique, like solder bumps, can be used to bond layers with TSVs.
Aldosterone remodels human endothelium

Aim: In response to aldosterone endothelial cells swell and stiffen. Although amiloride‐sensitive sodium and water uptake is known to be involved, the underlying mechanisms are yet unclear. We tested the hypothesis whether the intracellular accumulation of water or organic matter is responsible for the structural and functional alterations.
Emergence and Prevalence of Persistent and Residual Speech Errors

Abstract This report reviews the existing literature on the emergence and prevalence of speech sound errors in older children and adults. Findings from several different sources suggest that 1 to 2% of the young adult population overall may present with these errors. Up to 75% of these errors may resolve on their own between the end of the developmental period (i.e., age 9 years) and the end of high school, though speech therapy services may still be justified to reduce any negative social consequences of these errors. At least two different sources of these errors are postulated. Residual speech errors (the more common of the two types) appear to arise as a leftovers from a much earlier speech delay and were originally omission or substitution errors but migrated closer to normal to become distortions. Persistent speech errors, on the other hand, appear to be distortions from an early age that reflect long-instantiated habits. Whether this distinction points to different responses to particular interventions, or whether either type is more or less likely to resolve spontaneously is not clear at this time.
Resource allocation for broadband networks

The author suggests the use of congestion measures at the packet level, the burst level, and the call level to evaluate congestion for integrated traffic. These measures result from the fact that communication terminals can often be characterized in terms of call level, burst level, and packet level statistics. They can be used for the purpose of bandwidth allocation at these levels, virtually emulating the functions of circuit switching, fast circuit switching, and fast packet switching, respectively. Various methodologies are described for evaluating blocking probabilities at these levels. The analysis sheds light on traffic engineering issues such as appropriate link load, traffic integration, trunk group and switch sizing, and bandwidth reservation criteria for bursty services. <<ETX>>
Tumores Malignos Primários dos Ossos

The authors show the value of multidisciplinary treatment on limb sparing of patients with malignant bone tumors. From 1981 to 1994, 70% of 174 patients with osteosarcoma treated with pre-operative chemotherapy, had limb sparing surgery with recurrence rate of 4% in mean follow-up of 5 years. Similar results were achieved in patients with Ewing’s sarcoma. The authors print out the improvement in survival and quality of life with multidisciplinar approach. *Trabalho realizado no Departamento de Cirurgia Pélvica do Hospital A. C. Camargo da Fundação Antonio Prudente São Paulo SP. 1Titulares do Serviço de Ortopedia Diretor do Departamento de Cirurgia Pélvica Endereço para correspondência: Ademar Lopes Hospital A.C. Campos Rua Prof. Antonio Prudente, 211 São Paulo SP Descritores: Osteossarcoma Sarcoma de Ewing cirurgia
Intravenous dimethylsulfoxide therapy causes severe hemolysis mimicking a hemolytic transfusion reaction

new designation is anti-Rx, after the original proposita. Before use, urines should be centrifuged or filtered to remove particulate matter, and the pH should beadjusted to neutrality. The urines then should be dialyzed for 24 to 48 hours at 4OC against phosphate-buffered saline (pH 7.0 7.4). In some instances, dialysis against low-ionicstrength solution may be appropriate. ’ Finally, a negative control test with the dialysis fluid should always be included in inhibition studies as a check for “nonspecific”inhibition. W. JOHN JUDD, FIMLS, MI Biol Associate Professor of Medical Technology Department of Pathology University of Michigan Medical School Ann Arbor, Michigan
Jigsaw-Puzzle-Like 3D Glyphs for Visualization of Grammatical Constraints

Three-dimensional visualization using jigsaw-puzzle-like glyphs, or shapes, is proposed as a means of representing grammatical constraints in programming. The proposed visualization uses 3D glyphs such as convex, concave, and wireframe shapes. A semantic constraint, such as a type constraint in an assignment, is represented by an inclusive match between 3D glyphs. An application of the proposed visualization method to a subset of the Java programming language is demonstrated. An experimental evaluation showed that the 3D glyphs are easier to learn and enable users to more quickly understand their relationships than 2D glyphs and 1D symbol sequences.
Whole-Genome Sequencing for Detecting Antimicrobial Resistance in Nontyphoidal Salmonella

ABSTRACT Laboratory-based in vitro antimicrobial susceptibility testing is the foundation for guiding anti-infective therapy and monitoring antimicrobial resistance trends. We used whole-genome sequencing (WGS) technology to identify known antimicrobial resistance determinants among strains of nontyphoidal Salmonella and correlated these with susceptibility phenotypes to evaluate the utility of WGS for antimicrobial resistance surveillance. Six hundred forty Salmonella of 43 different serotypes were selected from among retail meat and human clinical isolates that were tested for susceptibility to 14 antimicrobials using broth microdilution. The MIC for each drug was used to categorize isolates as susceptible or resistant based on Clinical and Laboratory Standards Institute clinical breakpoints or National Antimicrobial Resistance Monitoring System (NARMS) consensus interpretive criteria. Each isolate was subjected to whole-genome shotgun sequencing, and resistance genes were identified from assembled sequences. A total of 65 unique resistance genes, plus mutations in two structural resistance loci, were identified. There were more unique resistance genes (n = 59) in the 104 human isolates than in the 536 retail meat isolates (n = 36). Overall, resistance genotypes and phenotypes correlated in 99.0% of cases. Correlations approached 100% for most classes of antibiotics but were lower for aminoglycosides and beta-lactams. We report the first finding of extended-spectrum β-lactamases (ESBLs) (blaCTX-M1 and blaSHV2a) in retail meat isolates of Salmonella in the United States. Whole-genome sequencing is an effective tool for predicting antibiotic resistance in nontyphoidal Salmonella, although the use of more appropriate surveillance breakpoints and increased knowledge of new resistance alleles will further improve correlations.
HIV vaccines

Defining immune correlates of protection against the human immunodeficiency virus (HIV) remains a major challenge. While the role of neutralizing antibodies and CD8+ T cell responses has been widely acknowledged and applied in vaccine development, little vaccine candidates have focused on CD4+ T cells. As the main target of HIV, CD4+ T cells play a pivotal role in HIV infection. An HIV vaccine that elicits strong, multi-specific, polyfunctional and persisting CD4+ T cell responses would therefore have the potential of lowering viral set point when HIV infection occurs or reducing viral load in already infected patients. In a combined approach with neutralizing antibodies and CD8+ T cells, CD4+ T cells cannot only enhance the magnitude, quality and durability of the desired antibody response, but will also provide the help needed to induce and maintain effective antiviral CD8+ T cell responses. In addition, the disease-modifying potential of the CD4+ T cell response, by lowering viral set point and/or viral load and thus probability of transmission, may be beneficial both at the individual and public health level.
Expectation maximization-based passive localization in asynchronous wireless networks

This paper studies TOA-based localization of a passive target with one transmitter and multiple distributed receivers. Different from the existing studies which assume synchronous or quasi-synchronous network, we consider a more practical case in which all the receivers have different time offsets to the transmitter. To tackle the multi-dimensional optimization problem in the maximum likelihood estimation, an expectation maximization (EM) algorithm is proposed. Taylor expansion to the result obtained in the expectation step is applied, which enables us to give a closed-form solution of localization in the maximization step. The Cramér-Rao bound of the target's position estimation with asynchronous receivers is derived. Simulation results show that the proposed EM-based algorithm outperforms the traditional methods and can perfectly attach the derived Cramér-Rao bound.
Functional communication and executive function in aphasia

The purpose of this exploratory study was to investigate the relationship between functional communication and executive function ability in aphasia. Twenty‐five participants with aphasia underwent examination with an extensive test battery including measures of functional communication, executive function ability, and language impairment. Compared to published norms, most participants did not perform within normal limits on the executive function tests. As expected, the correlation between severity of language impairment and functional communication ratings exceeded that among the executive functioning and functional communication measures. Eight of ten correlation coefficients for the relationship between executive functioning and functional communication reached statistical significance suggesting a clear relationship between scores on the executive functioning measures and functional communication ability. Based on these results, it appears that decreased executive functioning ability may coincide with decreased functional communication ability in persons with aphasia.
Probabilistic and Bayesian nonparametric approaches for recommender systems and networks. (Approches probabilistes et bayésiennes non paramétriques pour les systemes de recommandation et les réseaux)

We propose two novel approaches for recommender systems and networks. In the first part, we first give an overview of recommender systems and concentrate on the low-rank approaches for matrix completion. Building on a probabilistic approach, we propose novel penalty functions on the singular values of the low-rank matrix. By exploiting a mixture model representation of this penalty, we show that a suitably chosen set of latent variables enables to derive an expectation-maximization algorithm to obtain a maximum a posteriori estimate of the completed low-rank matrix. The resulting algorithm is an iterative soft-thresholded algorithm which iteratively adapts the shrinkage coefficients associated to the singular values. The algorithm is simple to implement and can scale to large matrices. We provide numerical comparisons between our approach and recent alternatives showing the interest of the proposed approach for low-rank matrix completion. In the second part, we first introduce some background on Bayesian nonparametrics and in particular on completely random measures (CRMs) and their multivariate extension, the compound CRMs. We then propose a novel statistical model for sparse networks with overlapping community structure. The model is based on representing the graph as an exchangeable point process, and naturally generalizes existing probabilistic models with overlapping block-structure to the sparse regime. Our construction builds on vectors of CRMs, and has interpretable parameters, each node being assigned a vector representing its level of affiliation to some latent communities. We develop methods for simulating this class of random graphs, as well as to perform posterior inference. We show that the proposed approach can recover interpretable structure from two real-world networks and can handle graphs with thousands of nodes and tens of thousands of edges.
Exposure to biohazards in wood dust: bacteria, fungi, endotoxins, and (1-->3)-beta-D-glucans.

Personal exposure to fungi, bacteria, endotoxin, and (1-->3)-beta-D-glucan was determined at different woodworking sites--logging sites, sawmills, woodchipping sites, and joineries. Exposure levels to fungi at logging sites and sawmills were in the range of 10(3)-10(4) cfu/m3, at the woodchipping mill, 10(3)-10(5) cfu/m3, and at joineries, 10(2)-10(4) cfu/m3. Although mean endotoxin levels were lower than the suggested threshold value of 20 ng/m3, some personal exposures at sawmills and a joinery exceeded the standard. The geometric mean personal (1-->3)-beta-D-glucan exposure level at the woodchipping mill was 2.32 ng/m3, at sawmills, 1.37 ng/m3, at logging sites, 2.02 ng/m3, and at joineries, 0.43 ng/m3. Highly significant associations were found between mean personal inhalable endotoxin exposures and Gram-negative bacteria levels (p < 0.0001), and mean personal inhalable (1-->3)-beta-D-glucan exposures and fungi levels (p = 0.0003). The prevalence of cough, phlegm, chronic bronchitis, nasal symptoms, frequent headaches, and eye and throat irritations was significantly higher among woodworkers than controls. Dose-response relationships were found between personal exposures and work-related symptoms among joinery workers and sawmill and chip mill workers.
Fault detection in λ-tuned control loops using an observer with integral action

A model-based fault detection algorithm assuming uncertain process parameters is used for detecting poorly operating λ-tuned control loops. The a priori information obtained from λ-tuning is used to create an observer as residual generator. The observer has integral action which makes it possible to obtain a tight fault detection threshold. A linear optimization approach is used for finding the parameters in the threshold