Miracle-dz/UniFAR-FTUs huggingface dataset:
Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer

Colon cancer has been viewed as the result of progressive accumulation of genetic and epigenetic abnormalities. However, this view does not fully reflect the molecular heterogeneity of the disease. We have analyzed both genetic (mutations of BRAF, KRAS, and p53 and microsatellite instability) and epigenetic alterations (DNA methylation of 27 CpG island promoter regions) in 97 primary colorectal cancer patients. Two clustering analyses on the basis of either epigenetic profiling or a combination of genetic and epigenetic profiling were performed to identify subclasses with distinct molecular signatures. Unsupervised hierarchical clustering of the DNA methylation data identified three distinct groups of colon cancers named CpG island methylator phenotype (CIMP) 1, CIMP2, and CIMP negative. Genetically, these three groups correspond to very distinct profiles. CIMP1 are characterized by MSI (80%) and BRAF mutations (53%) and rare KRAS and p53 mutations (16% and 11%, respectively). CIMP2 is associated with 92% KRAS mutations and rare MSI, BRAF, or p53 mutations (0, 4, and 31% respectively). CIMP-negative cases have a high rate of p53 mutations (71%) and lower rates of MSI (12%) or mutations of BRAF (2%) or KRAS (33%). Clustering based on both genetic and epigenetic parameters also identifies three distinct (and homogeneous) groups that largely overlap with the previous classification. The three groups are independent of age, gender, or stage, but CIMP1 and 2 are more common in proximal tumors. Together, our integrated genetic and epigenetic analysis reveals that colon cancers correspond to three molecularly distinct subclasses of disease.
Dynamics and M-Stability of Legged Robots

This article presents a theoretical approach for modeling and controlling the stability of legged robots. The new proposed concept is two-fold: (a) the definition of the (m-d)-stability and (b) the definition of the Virtual Generalized Stabilizer. These concepts are developed throughout a theoretical and general approach to the dynamics of legged robots. Numerical results are analyzed through the simulated behavior of a biped robot recovering a statically stable state under two conditions: an unstable initial posture and an impulsive external force.
Capacity Control of Social Media Diffusion for Real-Time Analysis System

In Twitter-like services, countless messages are being posted in real-time every second all around the world. Timely knowledge about what kinds of information are diffusing in social media is quite important. For example, in emergency situations such as earthquakes, users provide instant information on their situation through social media. The collective intelligence of social media is useful as a means of information detection complementary to conventional observation. We have developed a system for monitoring and analyzing information diffusion data in realtime by tracking retweeted tweets. A tweet retweeted by many users indicates that they find the content interesting and impactful. Analysts who use this system can find tweets retweeted by many users and identify the key people who are retweeted frequently by many users or who have retweeted tweets about particular topics. However, bursting situations occur when thousands of social media messages are suddenly posted simultaneously, and the lack of machine resources to handle such situations lowers the system’s query performance. Since our system is designed to be used interactively in real-time by many analysts, waiting more than one second for a query results is simply not acceptable. To maintain an acceptable query performance, we propose a capacity control method for filtering incoming tweets using extra attribute information from tweets themselves. Conventionally, there is a trade-off between the query performance and the accuracy of the analysis results. We show that the query performance is improved by our proposed method and that our method is better than the existing methods in terms of maintaining query accuracy. key words: information diffusion, social media, in-memory database, microblogging, stream processing
of the

—Most of today’s ADASs rely on the data of local perception sensors. With the introduction of Vehicle-to-X (V2X) communication, the perception range of next generation vehicles will be extended even further. In addition to the introduction of local perception sensors in Veins, we present ArteryLTE , a holistic simulation environment for using the vehicle position data from the microscopic trafﬁc simulator SUMO in combination with ETSI ITS G5 and LTE enabled vehicles, as well as a backend. We use the proposed simulation framework to present preliminary results for detecting lane-level trafﬁc phenomena
Success Stories: Communicating the School Health Message.

Background: Thirteen school district teams from Michigan and Indiana participated in the Michiana Coordinated School Health Leadership Institute with the intent of Coordinated School Health Program (CSHP) implementation. The study purpose was to analyze the utilization of success stories for documenting CSHP achievements. Methods: Throughout the three-year Institute, teams were introduced to the process of sharing success stories with school and community stakeholders and provided a common format for crafting stories. To conceptualize stories, data were analyzed via content analysis. Results: Success stories primarily focused on four CSHP components: physical education and activity, food and nutrition services, family and community involvement, and staff wellness. “Success” was typically defined through four avenues: receipt of grants and financial support, high participation rates, requests for followup events, and community support. Discussion: Stories are an effective strategy for communicating school health messages and successes. They provide advantages for both authors and audience members. For authors, composing a story may be a less intimidating process that does not require an extensive skill set. For audience members, the structure provides a memorable story line. This study helps substantiate the use of success stories as a practical tool for articulating and disseminating the importance of CSHP.
Synthesis of Graphene Nano Sheets by the Rapid Reduction of Electrochemically Exfoliated Graphene Oxide Induced by Microwaves

Graphene has been produced by various methods and techniques from various precursors. Here we demonstrate a simple and fast method of electrochemical exfoliation of graphite to graphene oxide (GO) and then its rapid reduction to graphene nano-sheets (GNs) with the help of microwaves. The samples prepared by this method were characterized with different techniques such as Ultra Violet-Visible spectrophotometry (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and Atomic force microscopy (AFM) to confirm their characteristic properties. The UV spectra of GO and GNs showed a sharp and intensive peaks centered at 266.5 nm and 230 nm. The FTIR spectra confirmed the oxidation of graphite and deoxygenation of the GO. Similarly, XRD analysis also confirmed the comparative layer structures of GO and GNS. The typical AFM morphology of GNs drop-casted on glass substrate ascertained the presence of few layers of graphene. This electrochemical exfoliation method and microwaves reduction offers a low-cost and efficient route to produce high quality graphene with high yield.
Sensory and verbal coding strategies in subjects with absolute pitch.

The performance of six absolute‐pitch and six control subjects was examined in three studies involving recognition memory for tone frequency. When the standard and comparison were 1/10 semitone apart, absolute‐pitch subjects reported using a sensory coding strategy and did not differ from the controls in overall performance or rate of forgetting. When the stimulus difference was 3/4 semitone, absolute‐pitch subjects shifted to a verbal coding strategy, and their memory for pitch was significantly better than the controls. With a one‐semitone difference, the absolute‐pitch group showed no significant forgetting over a 15‐sec retention interval filled with interference tones. These findings support the hypothesis that possessors of absolute pitch show superior pitch memory only when they can differentially label the stimuli with musical‐note names.
Atrial fibrillation management: a prospective survey in ESC member countries: the Euro Heart Survey on Atrial Fibrillation.

AIMS To describe atrial fibrillation (AF) management in member countries of the European Society of Cardiology (ESC) and to verify cardiology practices against guidelines. METHODS AND RESULTS Among 182 hospitals in 35 countries, 5333 ambulant and hospitalized AF patients were enrolled, in 2003 and 2004. AF was primary or secondary diagnosis, and was confirmed on ECG in the preceding 12 months. Clinical type of AF was reported to be first detected in 978, paroxysmal in 1517, persistent in 1167, and permanent in 1547 patients. Concomitant diseases were present in 90% of all patients, causing risk factors for stroke to be also highly prevalent (86%). As many as 69% of patients were symptomatic at the time of the survey; among asymptomatic patients, 54% were previously experienced symptoms. Oral anticoagulation was prescribed in 67 and 49% of eligible and ineligible patients, respectively. A rhythm control strategy was applied in 67% of currently symptomatic patients and in 44% of patients who never experienced symptoms. CONCLUSION This survey provides a unique snapshot of current AF management in ESC member countries. Discordance between guidelines and practice was found regarding several issues on stroke prevention and antiarrhythmic therapy.
Changes of adrenergic reaction pattern in experimental diabetes mellitus.

Changes of the adrenergic reaction pattern in experimental diabetes have been studied in rabbit aortic strip preparations. Strips taken from alloxan-treated diabetic rabbits showed increased noradrenaline (NA) sensitivity when compared to control preparations. A similar increase in NA sensitivity was noted in strips from prednisolone-treated, non-diabetic animals. Whereas in the control and prednisolone-treated groups, NA contractions could be blocked only by alphaand not by beta-adrenergic blocking agents, in diabetes both phentolamine, 0.5 |ig/ml, and propranolol, 0.5-2 M-g/ml, produced a significant parallel shift to the right of the NA dose-response curve. In control preparations isoproterenol (ISO) exerted only a contraction at high concentrations, which could be blocked by alpha-blocking agents. In diabetes sensitivity to this effect increased, and it became susceptible to beta-blocking agents. Sensitivity to phenylephrine remained the same in all 3 groups. After cold storage at + 5 C for 24 hr the NA sensitivity of strips from diabetic animals remained increased, whereas the inhibitory action of propranolol disappeared. It is concluded that separable quantitative (supersensitivity) and qualitative (vasoconstriction sensitive also to beta antagonists) changes in adrenergic reactions develop in experimental diabetes. Possible mechanisms for the 2 phenomena are discussed. {Endocrinology 93: 752, 1973) E H A N C E D responsiveness of the peripheral blood vessels to endogenous catecholamines in diabetes is a well-known phenomenon and it may account for the appearance of vascular disease in diabetic patients (1 ) . Since similar functional changes in the vascular reaction pattern precede by far and may underlie morphologic changes of the vessels, it is important to know whether increased catecholamine sensitivity is the only change in the functional state of the vessels or whether qualitative changes in the adrenergic receptor mechanism also appear in di-
Temperature during embryonic development has persistent effects on thermal acclimation capacity in zebrafish

Global warming is intensifying interest in the mechanisms enabling ectothermic animals to adjust physiological performance and cope with temperature change. Here we show that embryonic temperature can have dramatic and persistent effects on thermal acclimation capacity at multiple levels of biological organization. Zebrafish embryos were incubated until hatching at control temperature (TE = 27 °C) or near the extremes for normal development (TE = 22 °C or 32 °C) and were then raised to adulthood under common conditions at 27 °C. Short-term temperature challenge affected aerobic exercise performance (Ucrit), but each TE group had reduced thermal sensitivity at its respective TE. In contrast, unexpected differences arose after long-term acclimation to 16 °C, when performance in the cold was ∼20% higher in both 32 °C and 22 °C TE groups compared with 27 °C TE controls. Differences in performance after acclimation to cold or warm (34 °C) temperatures were partially explained by variation in fiber type composition in the swimming muscle. Cold acclimation changed the abundance of 3,452 of 19,712 unique and unambiguously identified transcripts detected in the fast muscle using RNA-Seq. Principal components analysis differentiated the general transcriptional responses to cold of the 27 °C and 32 °C TE groups. Differences in expression were observed for individual genes involved in energy metabolism, angiogenesis, cell stress, muscle contraction and remodeling, and apoptosis. Therefore, thermal acclimation capacity is not fixed and can be modified by temperature during early development. Developmental plasticity may thus help some ectothermic organisms cope with the more variable temperatures that are expected under future climate-change scenarios.
Laboratory Diagnosis of Antithrombin and Heparin Cofactor II Deficiency

Antithrombin activity should probably be determined in persons with early onset of recurrent thrombosis, especially if a family history is present. The initial screening test should be a heparin cofactor assay optimized to reduce the contribution of heparin cofactor II. If the heparin cofactor assay is low, an antigenic determination should be performed to rule out the possibility of an antithrombin variant. At the present time, there is insufficient evidence to recommend the routine determination of heparin cofactor II levels in patients with thrombosis.
Leadership and Culture in India: The GLOBE Research Project 1

in spite of the fact that the languages of India are many, and there are well marked differences between one regional culture and another, yet there is an over-all unity of design which makes them all members of one family. This stems primarily from the economic and social organization of the country and extends to commonness of intellectual and emotional attachments and obligations. The details might vary from place to place, and from one caste to another, yet the sameness of the traditions on which all of them have been reared cannot be overlooked (Bose, 1967, p.9).
Injectable vaccines for preventing pneumococcal infection in patients with chronic obstructive pulmonary disease.

BACKGROUND As chronic obstructive pulmonary disease (COPD) progresses, exacerbations can occur with increasing frequency. One goal of therapy is to prevent these exacerbations, thereby reducing morbidity and associated healthcare costs. Pneumococcal vaccinations are one strategy for reducing the risk of infective exacerbations. OBJECTIVES To determine the safety and efficacy of pneumococcal vaccination in COPD. The primary outcomes assessed were episodes of pneumonia and acute exacerbations. Secondary outcomes of interest included hospital admissions, adverse events related to treatment, disability, change in lung function, mortality, and cost effectiveness. SEARCH STRATEGY We searched the Cochrane Airways Group COPD trials register and the databases CENTRAL, MEDLINE and EMBASE using pre-specified terms. The latest searches were performed in March 2010. SELECTION CRITERIA Randomised controlled trials assessing the effects of injectable pneumococcal vaccine in people with COPD were included. DATA COLLECTION AND ANALYSIS Two review authors independently extracted data and three review authors independently assessed trial quality. MAIN RESULTS Seven studies were identified that met the inclusion criteria for this review and were included in the 2010 review update. Two older trials used a 14-valent vaccine and five more recent trials used a 23-valent injectable vaccine.In six studies involving 1372 people, the reduction in likelihood of developing pneumonia with pneumococcal vaccination compared to control did not achieve statistical significance, the odds ratio (OR) was 0.72 (95% confidence interval (CI) 0.51 to 1.01), with moderate heterogeneity present between studies. The reduction in likelihood of acute exacerbations of COPD from two studies involving 216 people was not statistically significant (Peto OR 0.58; 95% CI 0.30 to 1.13). Of the secondary outcomes for which data were available there was no statistically significant effect for reduction in hospital admissions (two studies) or emergency department visits (one study). There was no significant reduction in pooled results from three studies involving 888 people for odds of all-cause mortality for periods up to 48 months post-vaccination (OR 0.94; 95% CI 0.67 to 1.33), or for death from cardiorespiratory causes (OR 1.07; 95% CI 0.69 to 1.66). AUTHORS' CONCLUSIONS The limited evidence from randomised controlled trials (RCTs) included in this review suggests that, while it is possible that injectable polyvalent pneumococcal vaccines may provide some protection against morbidity in persons with COPD, no significant effect on any of the outcomes was shown. Further large RCTs in this population would be needed to confirm effectiveness of the vaccine suggested by results from longitudinal studies.
Road condition analysis using 3-axis accelerometer and GPS sensors

This work proposes road quality data analysis based on accelerometer and GPS sensors built into smartphone. Given paper particularly addresses the problem of road conditions. In order to study on road patterns we collected sufficient amount of data during the driving on different types of roads. In this paper, we provide visual representation of differences of consecutive accelerometer values. All examined cases consider speed of the moving vehicle.
Bats and birds increase crop yield in tropical agroforestry landscapes.

Human welfare is significantly linked to ecosystem services such as the suppression of pest insects by birds and bats. However, effects of biocontrol services on tropical cash crop yield are still largely unknown. For the first time, we manipulated the access of birds and bats in an exclosure experiment (day, night and full exclosures compared to open controls in Indonesian cacao agroforestry) and quantified the arthropod communities, the fruit development and the final yield over a long time period (15 months). We found that bat and bird exclusion increased insect herbivore abundance, despite the concurrent release of mesopredators such as ants and spiders, and negatively affected fruit development, with final crop yield decreasing by 31% across local (shade cover) and landscape (distance to primary forest) gradients. Our results highlight the tremendous economic impact of common insectivorous birds and bats, which need to become an essential part of sustainable landscape management.
Standards of Medical Care in Diabetes—2017: Summary of Revisions

In light of the American Diabetes Association’s (ADA’s) new position statement on psychosocial care in the treatment of diabetes, the “Standards of Medical Care in Diabetes,” referred to as the “Standards of Care,” has been updated to address psychosocial issues in all aspects of care including self-management, mental health, communication, complications, comorbidities, and life-stage considerations. Although levels of evidence for several recommendations have been updated, these changes are not addressed below as the clinical recommendations have remained the same. Changes in evidence level from, for example, E to C are not noted below. The 2017 Standards of Care contains, in addition to many minor changes that clarify recommendations or reflect new evidence, the following more substantive revisions.
Type A Personality & Coronary Artery Disease: A Case Control Study -

Background and objective: Cardiovascular diseases are becoming the major cause of morbidity and mortality in most of the developing countries including India. Various studies proposed that type A personality is an independent risk factor for coronary artery disease. Present study was carried out to study the role of type A personality in the occurrence of coronary artery disease. Materials and Methods: Present study was a hospital based paired matched case-control study, carried out at civil hospital, Ahmedabad. 135 newly diagnosed cases of coronary artery disease and 135 controls were studied after taking informed written consent. Data was analysed by using Epi-info version 3.5. 1 computer package, Chi -square test, and Odds ratio were calculated. Results: Among the total 135 cases 70.4% were male and 29.6% were female, most of the cases (40%) were belongs to the age group of 51-60 years. In our study significantly higher number of the cases (28.9%) having Type A personality as compared to controls (12.6%), and this difference was statistically significant (X2= 10.90, P < 0.001). Conclusion: findings of our study suggest that type A personality is major etiology behind the occurrence of coronary artery disease. Awareness should be created among the people regarding type A behavior and also promote various stress management techniques like breathing exercises, stretching exercises, yoga, meditation which are quite helpful in reducing the risk of CAD.
Mysticism: from the Eleusinian Mysteries to Today

In the Hellenistic world, ‘mystical’ referred to “secret” religious rituals, specifically starting with the Eleusinian Mysteries in Ancient Greece. The mysteries were taken up in the same form in the Roman Empire and then morphed, as the dominant religion in the West shifted from the Olympians to the Way. This paper first focuses on the original meaning of the word, specifically as it refers to the Eleusinian Mysteries, the most significant Pan-Hellenic transcendence initiation ceremony aimed at accepting death and opening the consciousness into the superhuman understanding. The origins of the concept of mysteries, exploring in particular the Eleusinian mysteries, are briefly described, by investigating accounts from classical texts and archeological evidence. In the beginning of the last century the term mysticism reappeared and evolved in definition in religious studies and an account of the understanding is presented in the second part. The definition of the term “experience” is complex in general and even more complex for a term such as “mystical experience”. The last part of this paper explores the idea of what constitutes a mystical experience and how it relates to the accounts from the Eleusinian Mysteries. This paper uses literary and scholarly sources, in Ancient Greek, Greek and English.
Realizing Efficient Volume Depletion in SOI Junctionless FETs

In this paper, we provide a simple and effective solution to realize efficient volume depletion and therefore, significantly reduce the OFF-state leakage current of a junctionless FET (JLFET) by replacing the SiO<sub>2</sub> by HfO<sub>2</sub> in the buried oxide (BOX). Using calibrated 2-D simulations, we show that the JLFET with a high-k BOX (HB JLFET) exhibits a considerably high I<sub>ON</sub>/I<sub>OFF</sub> ratio of ~10<sup>6</sup> even for a channel length of 20 nm. Further, we demonstrate that the use of a high-k BOX leads to a reduction in both gate capacitance C<sub>g</sub> and gate-to-drain feedback (Miller) capacitance C<sub>gd</sub>.