Miracle-dz/UniFAR-FTUs huggingface dataset:
Getting Histoplasmosis on the Map of International Recommendations for Patients with Advanced HIV Disease

Progressive disseminated histoplasmosis, caused by H. capsulatum, is a life-threatening illness and is an AIDS-defining opportunistic infection. It is neglected, worryingly under-diagnosed, and often misdiagnosed as cancer or tuberculosis with fatal consequences. Globally, over 100,000 cases of disseminated histoplasmosis have been estimated. In 2017, the World Health Organization (WHO) noted that disseminated histoplasmosis is a significant cause of mortality in AIDS patients. Through the rigorous efforts of the Global Action Fund for Fungal Infections (GAFFI) and partners, in 2019, the Histoplasma antigen test was included on the 2nd Edition of the WHO List of Essential Diagnostics. The drugs used in the treatment of histoplasmosis (amphotericin B and itraconazole) are on the WHO Essential Medicine List. The Manaus Declaration on histoplasmosis in the Americas and the Caribbean, where histoplasmosis kills more people with HIV than tuberculosis, advocates for universal access to rapid testing for histoplasmosis and availability of essential drugs for the treatment of histoplasmosis in every country by 2025. Hyperendemic areas are present in the Americas, Caribbean, Southeast Asia, and Latin America. In conclusion, histoplasmosis remains an important clinical and public health problem. To reduce HIV-associated mortality, disseminated histoplasmosis must be addressed through advocacy, increased awareness, and universal access to essential diagnostics and antifungal agents.
Bioactive Compounds, Antioxidant Activity, and Sensory Analysis of Rice-Based Extruded Snacks-Like Fortified with Bean and Carob Fruit Flours

Generally, extruded gluten-free foods are mostly phytochemically deficient. In this study inositol phosphates, α-galactosides, lectins, protease inhibitors, and phenols, their antioxidant activity and sensorial analysis of some rice/bean/whole carob fruit flour blends were determined in unprocessed (controls) and extruded formulations. The fortification of rice-based extrudates with both legumes has a positive influence on both their bioactive compound content and their acceptability by consumers. The extruded formulations contained around twice as much (p < 0.05) total α-galactosides than their unprocessed counterparts. Extrusion significantly reduced the phytic acid content (10%) and significantly increased the less phosphorylated forms (16%–70%). After extrusion, the lectins and protease inhibitors were eliminated. The different phenolic compounds mostly increased (11%–36%), notably in the formulations with carob fruit. The antioxidant activity and the different groups of phenols showed a positive correlation in the extrudates. All the experimental extrudates had higher amounts of bioactive compounds than the commercial extruded rice. Considering the amount of phytochemicals determined in the novel gluten-free extrudates and the scores of sensorial analysis, formulations containing 20%–40% bean and 5% carob fruit could be adequate in promoting health-related functions, helping to increase pulse consumption, and allowing the food industry to satisfy consumers’ requirement for functional foods.
The Effect of Group Composition and Mineral Supplementation during Rearing on Measures of Cartilage Condition and Bone Mineral Density in Replacement Gilts

Simple Summary The lifetime performance of commercial sows relies on longevity, which is dependent on good health, particularly, limb health. In many countries, young female pigs (gilts) intended for breeding are often reared with male finisher pigs destined for meat production. However, finisher diets are not designed to meet the needs of developing gilts and may not supply the necessary minerals to support good limb health. Moreover, gilts reared with uncastrated (i.e., entire) male pigs are exposed to high levels of sexual mounting and aggression, which may cause physical damage. This experiment investigated the effect of female-only or mixed-sex rearing with and without supplementary minerals (Copper, Zinc and Manganese) on locomotory ability, cartilage condition and areal bone mineral density (aBMD) of breeding age gilts. The addition of the minerals to the diet resulted in increased aBMD in the humerus bone compared to gilts on the control diet. Rearing gilts in female-only groups reduced the number of cartilage lesions, and there were fewer incidences of elbow cartilage fractures. Overall, both strategies (mineral supplementation and female-only rearing) had benefits for limb health, which could help to improve sow longevity. Abstract Lameness is a major cause of poor longevity and poor welfare in replacement gilts. The problem is exacerbated by inappropriate housing and diet during the rearing period. Replacement gilts are often reared with male finisher pigs destined for slaughter. If they are not castrated, they perform high levels of potentially injurious sexual and aggressive behaviour. Furthermore, finisher pig diets are not designed to meet the needs of developing gilts and may not supply the necessary minerals to support good limb health. The objective of this study was to evaluate the effect of supplementing the diet of replacement gilts with copper, zinc and manganese and separating them from males during the rearing period on locomotory ability, bone mineral density and cartilage lesion scores. A 2 × 2 factorial design experiment investigated the effect of female-only or mixed-sex rearing, with or without supplementary minerals (Copper, Zinc and Manganese). In total, 384 maternal line gilts were assigned to 32 pens of 12 and were locomotion scored during the rearing period. A sub-sample (n = 102) of gilts were culled at breeding age and the front right limb was removed at slaughter. Areal bone mineral density (aBMD) was measured using dual energy X-ray absorptiometry, after which the limb was dissected to score the condition of the cartilage. The addition of trace minerals to the diet resulted in increased aBMD in the humerus (P < 0.05) compared to the control diet. Rearing gilts in female-only groups reduced the number of cartilage lesions overall (P < 0.05), and on the humeral condyle (P < 0.05). Rearing replacement gilts in female-only groups and with mineral supplementation had benefits for limb health.
Does self-determined motivation interact with environmental contexts to influence moderate-to-vigorous physical activity during a girls’ youth sport camp?

ABSTRACT Objective: To explore whether basketball player’s self-determined motivation interacts with environmental contexts and coach training to influence percentage time in moderate-to-vigorous physical activity (%MVPA). Methods: A secondary analysis of data from 76 girls (mean ± SD, 10.5 ± 1.0 years) was conducted. Players were classified as high self-determined motivation (HSDM) or low self-determined motivation (LSDM) and randomised to trained (intervention) or untrained (control) coaches. Training included 2 workshops on strategies for activity-promoting practices. Girls were exposed to environmental contexts (practices and games) led by a trained/untrained coach (depending on arm) and one without coaches (free time) daily. Girls wore accelerometers each day. Using mixed random-effects models, the influence of motivation, context and training on %MVPA was analysed. Results: Trained coaches’ practices were associated with the greatest %MVPA with no difference between HSDM and LSDM players (38.28 ± 1.77%; 37.64 ± 1.80%; p = 0.66). HSDM players had significantly greater %MVPA versus LSDM players during untrained coaches’ practices (23.58 ± 1.77%; 20.51 ± 1.78%; p = 0.03). During games with trained coaches, HSDM players had greater %MVPA compared to LSDM players (23.79 ± 1.76%; 18.56 ± 1.74%; p < 0.001). No between-group difference in %MVPA during free time was found (12.85 ± 0.82%; 13.39 ± 0.84%; p = 0.64). Conclusion: The impact of individual differences in self-determined motivation on %MVPA during practices was attenuated when coaches were trained to implement activity-promoting practices.
Stride and Step Length Obtained with Inertial Measurement Units during Maximal Sprint Acceleration

During sprint acceleration, step length, step rate, ground contact, and airtime are key variables for coaches to guide the training process and technical development of their athletes. In the field, three of these variables are easily obtained with inertial measurement units (IMUs), but, unfortunately, valid estimates of step length with IMUs currently are limited to low speeds (<50% max). A simple method is proposed here to derive step length during maximal sprint acceleration, using IMUs on both feet and two timing gates only. Mono-exponential velocity-time functions are fitted to the 30-m (split) and 60-m times, which in combination with IMU-derived step durations yield estimates of step length. To validate this approach, sixteen well-trained athletes with IMUs on the insteps of both feet executed two 60-m maximal sprints, starting from a three-point position. As a reference, step lengths were determined from video data. The reference step lengths combined with IMU-derived step durations yielded a time series of step velocity that confirmed the appropriateness of a mono-exponential increase of step velocity (R2 ≥ 0.96). The comparison of estimated step lengths to reference measurements showed no significant difference (p > 0.05) and acceptable agreement (root mean square error, RMSE = 8.0 cm, bias ± Limits of Agreement = −0.15 ± 16 cm). Step length estimations further improved (RMSE = 5.7 cm, −0.16 ± 11 cm) after smoothing the original estimated step lengths with a third order polynomial function (R2 = 0.94 ± 0.04). In conclusion, during maximal sprint acceleration, acceptable estimates of stride and step length were obtained from IMU-derived step times and 30-m (split) and 60-m sprint times.
Energy-Efficient Multi-Disjoint Path Opportunistic Node Connection Routing Protocol in Wireless Sensor Networks for Smart Grids

The gradual increase in the maturity of sensor electronics has resulted in the increasing demand for wireless sensor networks for many industrial applications. One of the industrial platforms for efficient usage and deployment of sensor networks is smart grids. The critical network traffic in smart grids includes both delay-sensitive and delay-tolerant data for real-time and non-real-time usage. To facilitate these traffic requirements, the asynchronous working–sleeping cycle of sensor nodes can be used as an opportunity to create a node connection. Efficient use of wireless sensor network in smart grids depends on various parameters like working–sleeping cycle, energy consumption, network lifetime, routing protocol, and delay constraints. In this paper, we propose an energy-efficient multi-disjoint path opportunistic node connection routing protocol (abbreviated as EMOR) for sensor nodes deployed in neighborhood area network. EMOR utilizes residual energy, availability of sensor node’s buffer size, working–sleeping cycle of the sensor node and link quality factor to calculate optimum path connectivity after opportunistic connection random graph and spanning tree formation. The multi-disjoint path selection in EMOR based on service differentiation of real-time and non-real-time traffic leads to an improvement in packet delivery rate, network lifetime, end-end delay and total energy consumption.
Metabolic comorbidities and medical institution utilization among breast cancer survivors: a national population-based study

Background/Aims We investigated metabolic comorbidity status and patterns of medical institution utilization among breast cancer survivors using medical claims data from the Health Insurance Review and Assessment Service (HIRA). Methods Using claims data obtained from the HIRA, we selected breast cancer survivors between 2010 and 2015. Descriptive statistics were calculated to determine the frequency of metabolic comorbidities, as well as to analyze patterns of medical institution utilization in accordance with disease status. Results A total of 89,953 breast cancer survivors were identified. Among these, 12,364 (13.7%) had hypercholesterolemia, 20,754 (23.1%) had hypertension (HTN), and 11,102 (12.3%) had diabetes mellitus (DM). In particular, more than half of breast cancer survivors older than 60 years had HTN, and other diseases sharply increased beginning at age 50 years. For HTN, a total of 531,292 claims were submitted; more than 80% (n = 473,737) were from primary medical institutions, whereas only 2.4% (n = 12,551) were from tertiary medical institutions. The number of claims submitted for DM was 231,526; those from primary medical institutions accounted for 68.5% (n = 158,566), whereas claims from tertiary medical institutions accounted for 12.0% (n = 27,693). In subgroup analyses, the utilization of secondary and tertiary medical institutions was higher among patients with severe diseases and those diagnosed following their breast cancer diagnosis. Conclusions More than 10% of breast cancer survivors were diagnosed with a metabolic comorbidity. Through analysis of medical institution utilization patterns, we ascertained that a communication system linking secondary and tertiary medical institutions with primary medical institutions is needed.
The dietary education trial in carbohydrate counting (DIET-CARB Study): study protocol for a randomised, parallel, open-label, intervention study comparing different approaches to dietary self-management in patients with type 1 diabetes

Introduction Clinical guidelines recommend that patients with type 1 diabetes (T1D) learn carbohydrate counting or similar methods to improve glycaemic control. Although systematic educating in carbohydrate counting is still not offered as standard-of-care for all patients on multiple daily injections (MDI) insulin therapy in outpatient diabetes clinics in Denmark. This may be due to the lack of evidence as to which educational methods are the most effective for training patients in carbohydrate counting. The objective of this study is to compare the effect of two different educational programmes in carbohydrate counting with the usual dietary care on glycaemic control in patients with T1D. Methods and analysis The study is designed as a randomised controlled trial with a parallel-group design. The total study duration is 12 months with data collection at baseline, 6 and 12 months. We plan to include 231 Danish adult patients with T1D. Participants will be randomised to one of three dietician-led interventions: (1) a programme in basic carbohydrate counting, (2) a programme in advanced carbohydrate counting including an automated bolus calculator or (3) usual dietary care. The primary outcome is changes in glycated haemoglobin A1c or mean amplitude of glycaemic excursions from baseline to end of the intervention period (week 24) between and within each of the three study groups. Other outcome measures include changes in other parameters of plasma glucose variability (eg, time in range), body weight and composition, lipid profile, blood pressure, mathematical literacy skills, carbohydrate estimation accuracy, dietary intake, diet-related quality of life, perceived competencies in dietary management of diabetes and perceptions of an autonomy supportive dietician-led climate, physical activity and urinary biomarkers. Ethics and dissemination The protocol has been approved by the Ethics Committee of the Capital Region, Copenhagen, Denmark. Study findings will be disseminated widely through peer-reviewed publications and conference presentations. Trial registration number ClinicalTrials.gov Registry (NCT03623113).
Simple photoplethysmography pulse encoding technique for communicating the detection of peripheral arterial disease—a proof of concept study

Objective: To assess the feasibility of novel photoplethysmography (PPG) Pulse Sounder/Pulse Visualizer communication techniques for alerting the presence (or absence) of peripheral arterial disease (PAD). Approach: Proof of concept evaluation using our previously published multi-site PPG pulse data set (110 participants included; age > 40 years; 44% PAD by ankle brachial pressure index (ABPI)). Two main pulse encoding rules using the risetime as an example feature to mark each heartbeat in a 6 s analysis study window: if risetime at both great toes ⩽time threshold (‘no PAD’ state) then heartbeat marked with a single 5 kHz audio tone; if risetime from either great toe > threshold (‘PAD’) then heartbeat marked with a distinct train of 5 kHz audio tones. A simple spectrogram visual plot was also produced for each participant’s audio signals. ROC curve analysis first determined an appropriate risetime threshold using the simple-to-evaluate PAD Visualizer and then re-tested at this level with PAD Sounder and classification performance summarized. Main results: The pulse encoding rules used were easy to learn. Visualizer best communication performance at risetime 0.27 s gave specificity 80.6%, sensitivity 95.8%, accuracy 87.3%, negative predictive value 96.2%, and Kappa statistic of 0.75. Classification performance for blinded assessment with audio PAD Sounder was identical. Significance: Substantial agreements demonstrated between Sounder/Visualizer disease techniques and the ABPI PAD reference. These simple-to-use PAD communications methods when embedded into an appropriate device platform could offer significant benefits in PAD diagnosis for a range of clinical settings, including primary care where low-cost, portable and easy-to-use diagnostics can be desirable.
Bioinspired magnetoreception and navigation in nonorthogonal environments using magnetic signatures

Diverse taxa use Earth’s magnetic field in conjunction with other sensory modalities to accomplish navigation tasks ranging from local homing to long-distance migration across continents and ocean basins. However, despite extensive research, the mechanisms that underlie animal magnetoreception are not clearly understood, and how animals use Earth’s magnetic field to navigate is an active area of investigation. Concurrently, Earth’s magnetic field offers a signal that engineered systems can leverage for navigation in environments where man-made systems such as GPS are unavailable or unreliable. Using a proxy for Earth’s magnetic field, and inspired by migratory animal behavior, this work implements a behavioral strategy that uses combinations of magnetic field inclination and intensity as rare or unique signatures that mark specific locations. Specifically, to increase the realism of previous work, in this study, a simulated agent uses a magnetic signatures based strategy to migrate in magnetic environments where lines of constant inclination and intensity are not necessarily orthogonal. The results further support existing notions that some animals may use combinations of magnetic properties as navigational markers, and provide insights into features and constraints that could enable navigational success or failure in either a biological or engineered system.
KCa3.1 Channels Confer Radioresistance to Breast Cancer Cells

KCa3.1 K+ channels reportedly contribute to the proliferation of breast tumor cells and may serve pro-tumor functions in the microenvironment. The putative interaction of KCa3.1 with major anti-cancer treatment strategies, which are based on cytotoxic drugs or radiotherapy, remains largely unexplored. We employed KCa3.1-proficient and -deficient breast cancer cells derived from breast cancer-prone MMTV-PyMT mice, pharmacological KCa3.1 inhibition, and a syngeneic orthotopic mouse model to study the relevance of functional KCa3.1 for therapy response. The KCa3.1 status of MMTV-PyMT cells did not determine tumor cell proliferation after treatment with different concentrations of docetaxel, doxorubicin, 5-fluorouracil, or cyclophosphamide. KCa3.1 activation by ionizing radiation (IR) in breast tumor cells in vitro, however, enhanced radioresistance, probably via an involvement of the channel in IR-stimulated Ca2+ signals and DNA repair pathways. Consistently, KCa3.1 knockout increased survival time of wildtype mice upon syngeneic orthotopic transplantation of MMTV-PyMT tumors followed by fractionated radiotherapy. Combined, our results imply that KCa3.1 confers resistance to radio- but not to chemotherapy in the MMTV-PyMT breast cancer model. Since KCa3.1 is druggable, KCa3.1 targeting concomitant to radiotherapy seems to be a promising strategy to radiosensitize breast tumors.
Impact of dietary chitosan oligosaccharide and its effects on coccidia challenge in broiler chickens

ABSTRACT 1. Two experiments were conducted, the first to determine the optimum inclusion of chitosan oligosaccharide (COS) in broiler diets to support growth performance, digestive functions, intestinal morphology, and immune organs. The second experiment evaluated the immune-protective properties of COS on broiler chickens during coccidia challenge (CC). 2. Experiment 1 investigated the effect of graded dietary concentration of COS in the diets of broiler chickens using eight cage replicates for each of the six diets. A corn-soybean meal-based diet was used as the basal diet and supplemented with 0.0, 0.5, 1.0, 1.5, 2.0, or 2.5 g of COS/kg feed to form the six treatments. 3. The diet supplemented with 1.0 g COS/kg of feed provided the optimal inclusion level for broiler chickens regarding body weight (BW) gain, jejunal villus height, villus height to crypt depth ratio, and ileal energy digestibility at d 22 of age. 4. Experiment 2 investigated the immune-protective properties of COS in broiler chickens during CC. A total of 224 male broiler chicks were randomly assigned to eight replicate cages in a 2 × 2 factorial arrangement of treatments with two COS concentrations (0 or 1 g of COS/kg of diet), with or without CC. 5. On d 18 of age, birds in the CC group received twice the recommended coccidia vaccine dose of 30 doses/kg BW. 6. Coccidia challenge reduced (P < 0.05) and dietary COS increased (P < 0.05) BW gain, and feed intake. Dietary COS mitigated (P < 0.05) the CC-induced effects on gain:feed. Dietary COS supplementation attenuated the CC-induced effects (P < 0.05) on the expression of occludin genes. 7. In conclusion, dietary COS improved performance, and the immune-related beneficial impact of COS supplementation was associated with reduced expression of pro-inflammatory cytokine genes.
Chronic Diseases Diagnosis using Machine Learning

As the chronicle disease is long lasting diseases, it takes the long period to diagnosis. The chronicle disease is a threatening disease all over the world, its cost more to diagnosis, as some of the chronicle diseases are unable to diagnose, the patient has to suffer throughout his lifetime. This kind disease data are available hugely in the medical field, to make easier for healthcare system the data mining approaches are applied. As in this project, five chronicle dataset are taken and the machine learning approaches are applied, the machine learning algorithms such as decision tree, random forest, and the support vector machine are applied and the predicted whether the patient is suffering from a disease. The chronicle disease such as heart disease, liver disease, diabetes, disease dataset is retrieved from the open source and applied the data mining process to all the dataset. As we get the result by comparing all algorithms performance on all dataset the random forest predicts with high accuracy.
A method for predicting IT vulnerabilities using Branching Processes – an outline

Being able to predict vulnerability existence in future software releases may have a considerable impact on assessing software security risk during its lifecycle. Some of the existing quantitative models for vulnerability analysis have been developed relying on dedicated software data thus, their real scenario implementation may be sometimes limited. The article focuses on the attempt to propose an outline of the method for predicting software vulnerabilities, based on the use of Branching Processes.