Miracle-dz/UniFAR-FTUs huggingface dataset:
OPERA: Reasoning about continuous common knowledge in asynchronous distributed systems

This paper introduces a new family of consensus protocols, namely \emph{Lachesis-class} denoted by $\mathcal{L}$, for distributed networks with guaranteed Byzantine fault tolerance. Each Lachesis protocol $L$ in $\mathcal{L}$ has complete asynchrony, is leaderless, has no round robin, no proof-of-work, and has eventual consensus. The core concept of our technology is the \emph{OPERA chain}, generated by the Lachesis protocol. In the most general form, each node in Lachesis has a set of $k$ neighbours of most preference. When receiving transactions a node creates and shares an event block with all neighbours. Each event block is signed by the hashes of the creating node and its $k$ peers. The OPERA chain of the event blocks is a Directed Acyclic Graph (DAG); it guarantees practical Byzantine fault tolerance (pBFT). Our framework is then presented using Lamport timestamps and concurrent common knowledge. Further, we present an example of Lachesis consensus protocol $L_0$ of our framework. Our $L_0$ protocol can reach consensus upon 2/3 of all participants' agreement to an event block without any additional communication overhead. $L_0$ protocol relies on a cost function to identify $k$ peers and to generate the DAG-based OPERA chain. By creating a binary flag table that stores connection information and share information between blocks, Lachesis achieves consensus in fewer steps than pBFT protocol for consensus.
Tofacitinib for the treatment of ulcerative colitis

ABSTRACT Introduction: New generations of small molecules are being developed for the treatment of ulcerative colitis. Among them, tofatinib (a Janus kinase (JAK) inhibitor) has demonstrated efficacy for inducing and maintaining remission and achieving mucosal healing with a reasonable safety profile. Oral administration is attractive for patients and lack of immunogenicity represents an advantage over biologic drugs. Areas covered: This review discusses the molecular aspects of the JAK-STAT pathway; the mechanism of action of tofacitinib pertinent to ulcerative colitis and the evidence on the efficacy of tofacitinib for achieving clinically relevant outcomes, including clinical remission, mucosal healing, and normalization of quality of life, as well as safety aspects with special attention to adverse events related to the mode of action of the drug. Expert commentary: Tofacitinib will be the first drug on the class of JAK inhibitors to be available for treatment of ulcerative colitis. The efficacy of the drug, with a rapid onset of action even in cases of severe colitis, oral administration, and possibility to use the drug intermittently without generating immunogenicity, will bring about a redesign of current treatment paradigms for ulcerative colitis.
Calendula officinalis: Potential Roles in Cancer Treatment and Palliative Care

A continuous challenge in cancer management is to improve treatment efficacy and to diminish its side effects. Consequently, new conventional and unconventional drugs and bioactive compounds from plants are constantly developed, characterized, and used for in vitro and in vivo models. This review focuses on the antitumor properties of Calendula officinalis, its biological and molecular effects in tumor cells and animal models, as well as its role in cancer palliative care. A systematic review of studies describing the cytotoxic role of C officinalis and its therapeutic role on cancer cells were carried out using the PubMed database. Albeit C officinalis extracts have cytotoxic activity toward different cancer cell lines, a high grade of variation between studies was observed, depending on plant organ subjected to extraction, extraction method, and the cancer cell lines used for each study. Nevertheless, its cytotoxic activity is related to a few bioactive compounds, presenting multiple roles in both activation of proapoptotic proteins and decreasing the expression of the proteins that inhibit cell death. Moreover, due to its anti-genotoxic/protective as well as antitumor and antimetastatic effects proven in animal models, C officinalis could have important future implications in developing novel cancer treatment strategies, while until now it has been used especially for diminishing the side effects of radiotherapy.
CEACAM1 Is Associated With the Suppression of Natural Killer Cell Function in Patients With Chronic Hepatitis C

Natural killer cells (NK cells) play an essential role in the immunological mechanism underlying chronic hepatitis C (CHC). Impairment of NK cell function facilitates persistent infection with hepatitis C virus (HCV) and hepatocellular carcinogenesis. However, the mechanism by which NK cell activity is suppressed in CHC is not completely understood. In this study, we focused on carcinoembryonic antigen–related cell‐adhesion molecule 1 (CEACAM1). CEACAM1 is thought to suppress NK cell function. We examined the effect of CEACAM1 on NK cell function in CHC. We investigated the function of CEACAM1 in vitro using Huh7.5. 1 cells and the HCV‐Japanese fulminant hepatitis (JFH)‐1 strain. We analyzed serum CEACAM1 level, NK cell function, and CEACAM1 messenger RNA (mRNA) level in human liver samples. Levels of CEACAM1 on the cell surface, CEACAM1 mRNA levels, and soluble CEACAM1 levels in supernatants were significantly higher in Huh7.5. 1 cells infected with JFH‐1 (Huh7.5.1/JFH‐1 cells) than in Huh7.5. 1 cells. Significantly higher NK cell cytotoxicity was observed toward K562 cells after coculture with CEACAM1 knockout Huh7.5. 1/JFH‐1 cells than after coculture with Huh7.5. 1/JFH‐1 cells. CEACAM1 expression was induced by the HCV E2 glycoprotein in HCV infection. Significantly higher serum CEACAM1 levels were detected in patients with CHC compared with healthy subjects and patients who achieved sustained virological responses. The expression of CD107a on NK cells from patients with CHC was negatively correlated with serum CEACAM1 levels. Significantly higher levels of CEACAM1 mRNA were detected in HCV‐infected livers compared with uninfected livers. Conclusion: CEACAM1 expression was induced in hepatocytes following HCV infection and decreased NK cell cytotoxicity. These results demonstrate a possible role for CEACAM1 in the pathogenesis of CHC and hepatocellular carcinoma progression.
Action Model Acquisition using LSTM

In the field of Automated Planning and Scheduling (APS), intelligent agents by virtue require an action model (blueprints of actions whose interleaved executions effectuates transitions of the system state) in order to plan and solve real world problems. It is, however, becoming increasingly cumbersome to codify this model, and is more efficient to learn it from observed plan execution sequences (training data). While the underlying objective is to subsequently plan from this learnt model, most approaches fall short as anything less than a flawless reconstruction of the underlying model renders it unusable in certain domains. This work presents a novel approach using long short-term memory (LSTM) techniques for the acquisition of the underlying action model. We use the sequence labelling capabilities of LSTMs to isolate from an exhaustive model set a model identical to the one responsible for producing the training data. This isolation capability renders our approach as an effective one.
KOH modified Thevetia peruviana shell activated carbon for sorption of dimethoate from aqueous solution

Abstract Modified Thevetia peruviana shell activated carbon for sorption of dimethoate from aqueous solution derived with potassium hydroxide (KOH) was studied at different concentrations for its potential application in water treatment. The batch sorption was investigated using dimethoate solution of 10–100 mg/L concentrations. Proximate analysis was determined and changes on the surfaces and structure of the TPS were characterized after chemical activation with KOH using XRD, FTIR, SEM–EDAX, pHpzc, BET. The quantum chemical calculation for dimethoate yielded molecule associated energies of –9.8421 (HOMO) and –2.3879 (LUMO) and a total energy of –53,376.2. The kinetic of the sorption was modeled which indicated the sorption equilibrium time as 90 min and pseudo-first order kinetics model showing R2 = 0.994 provided a better description of the process. Analysis of sorption equilibrium revealed that the data fitted well to Freundlich sorption isotherm model (R2 = 0.966), indicating multi-layer sorption of dimethoate on the surface of sorbent. The sorption of dimethoate onto KOHTPS shows 92.60% removal efficiency.
Do criminal associates impact psychiatric inpatients’ social support and interpersonal needs?

Abstract Suicide risk is elevated among psychiatric inpatients; however, research has not examined moderators of the associations between perceived social support and thwarted belongingness (TB) and perceived burdensomeness (PB), such as involvement with criminal associates. Adult psychiatric inpatients (N = 142) completed assessments. Perceived social support was negatively associated with TB and PB; however, associates’ criminal involvement did not moderate these associations. A significant interaction indicated a stronger negative association between perceived social support and TB when participants spent more time with associates. Therefore, time spent with associates, regardless of criminal involvement, may be a relevant interpersonal suicide risk factor.
THE CLINICAL PRESENTATION OF PRIMARY HYPERPARATHYROIDISM: A SOUTHERN EUROPEAN PERSPECTIVE OVER THE LAST 2 DECADES.

OBJECTIVE The clinical presentation of primary hyperparathyroidism (PHPT) has changed widely in developed countries in the last few decades. We evaluated its variations in our series over a 20-year period (i.e., 1997-2016). METHODS A retrospective survey was conducted in our series of 364 well-characterized consecutive patients, arbitrarily divided into 4 consecutive 5-year periods at diagnosis. RESULTS In the overall series, only estimated glomerular function (eGFR) and urinary calcium (UCa) showed a significant upward trend ( P = .032 and .039, respectively), whereas demographic and clinical characteristics were stable. The UCa upward trend was also confirmed for the subgroup of symptomatic patients ( P = .013). No difference was observed in the demographic, clinical, or biochemical characteristics of asymptomatic patients or in the fraction of patients meeting surgical criteria. CONCLUSION The clinical presentation of PHPT was stable over 20 years in our large series. ABBREVIATIONS Ca = calcium; eGFR = estimated glomerular filtration rate; 25OHD = 25-hydroxyvitamin D; PHPT = primary hyperparathyroidism; PTH = parathyroid hormone; UCa = urinary calcium.
Youth Speak Out on School Food Environments

In Philadelphia, over 40% of youth are overweight or obese. The objective in this assessment was to learn about urban residents’ perspectives regarding the local food environment and its impact on eating behaviors. Using photo-elicitation, 20 adolescents reflected on their food environments through photographs and corresponding interviews. Without specific prompting from interviewers, every participant raised concerns about their school food environments, which they commonly found to be unhealthy and unappealing. Participants’ responses reflected four themes: (1) mixed reviews regarding the healthfulness of school vending machines, (2) lunch from home versus lunch from school, (3) factors that influenced food choice at school, and (4) critiques of school food environments. Students embraced the photo-elicitation approach as a way to convey their concerns and to suggest opportunities for improvements. School nurses, who are trusted by students and school personnel, are well-positioned to solicit student input and advocate for healthier school food environments.
A mono-component microbial protease improves performance, net energy, and digestibility of amino acids and starch, and upregulates jejunal expression of genes responsible for peptide transport in broilers fed corn/wheat-based diets supplemented with xylanase and phytase

ABSTRACT A total of 90 male Ross 308 broiler chicks were used in a digestibility and performance bioassay to explore the effect of reduction in dietary protein and digestible amino acids and inclusion of an exogenous mono‐component protease on amino acid digestibility, net energy, jejunal gene expression, and bird performance. Four dietary treatments were created by the supplementation, or not, of 2 control diets with a mono‐component exogenous protease. The control diets were corn/wheat/soybean meal‐based and were formulated to be either nutritionally adequate or reduced in protein and amino acids (around 3%). The 2 control diets were supplemented with xylanase and phytase (2000 FYT). Treatments were therefore arranged as a 2 × 2 factorial design. The reduction in diet nutrient density had no significant effect on various experimental outcomes (including bird performance, amino acid digestibility, and net energy [NE]) that were measured with the exception of a reduction in the expression of aminopeptidase N and glucose transporter 2. However, the addition of exogenous protease resulted in an increase in weight gain and a reduction in feed conversion ratio (around 4%; P < 0.05) and an increase in the digestibility of several amino acids (P < 0.05) and starch (P = 0.06). Protease addition also resulted in an increase in both apparent metabolizable energy (AME) (+73 kcal/kg; P < 0.05) and NE (+107 kcal/kg; P < 0.05). The addition of exogenous protease to the diet also increased the jejunal expression of genes responsible for peptide transport (PepT2; P < 0.01) and starch digestion (sucrase isomaltase; P = 0.06). These results confirm the efficacy of exogenous protease in broiler diets that contain both xylanase and phytase and suggest substantial beneficial effects that extend beyond protein and amino acid nutrition. The effect of exogenous protease on energy partitioning, starch digestibility and the efficiency of nitrogen cycling is an area for further study.
Lateralization Value of Low Frequency Band Beamformer Magnetoencephalography Source Imaging in Temporal Lobe Epilepsy

Objective: In presurgical evaluation of temporal lobe epilepsy (TLE), selection of the resection side is challenging when bilateral temporal epileptiform discharges or structural abnormalities are present. We aim to evaluate the lateralization value of beamformer analysis of magnetoencephalography (MEG) in TLE. Methods: MEG data from 14 TLE patients were analyzed through beamformer analysis. We measured the hemispherical power distribution of beamformer sources and calculated the lateralization index (LI). We calculated the LI at multiple frequencies to explore the frequency dependency and at the delta frequency to define laterality. LI values ranging from −1 to −0.05 indicated right hemispheric dominance. LI values ranging from 0.05 to 1 indicated left hemispheric dominance. LI values ranging from −0.05 to 0.05 defined bilaterality. We measured the power of beamformer sources with a 9-s duration to explore time dependency. Results: The beamformer analysis showed that 10/14 patients had power dominance ipsilateral to resection. The delta frequency band had a higher lateralization value than other frequency bands. A time-dependent power fluctuation was found in the delta frequency band. Conclusions: MEG beamformer analysis, especially in the delta band, might efficiently provide additional information regarding lateralization in TLE.
Resonator Based Switching Technique between Ultra Wide Band (UWB) and Single/Dual Continuously Tunable-Notch Behaviors in UWB Radar for Wireless Vital Signs Monitoring

This paper presents a novel resonator that can switch and create three important behaviors within the same antenna using miniaturized capacitors. The resonator was integrated into conventional Ultra-Wide Band (UWB) antenna to achieve UWB and Single/Dual continuously tunable-notch behaviors. The Single/Dual notched was continuously tuned to our desired frequency band by changing the value of the capacitors. The antenna designed and fabricated to validate these behaviors had a compact size of 24 × 30.5 mm2, including the ground plane. The radiation patterns were very clean due to the placement of the proposed resonator in the special ground plane. Moreover, the presented novel resonator and switching technique was compared with the recently proposed resonators and their switching techniques. The prototype for the antenna was also developed in order to validate its performance in wireless vital signs monitoring. The presented miniaturized resonator based antenna was utilized for tumor sensing and simulations were provided in this regard. Moreover, the deployment of the proposed resonator based UWB antenna sensor in Pipeline Integrity Monitoring system was also investigated and discussed.
Restoration of Movement using FES: An Introductory Study I

FES has been applied for movement restoration, rehabilitation and therapy in spinal cord injury and nervous system failure subjects, whose number rise worldwide every year. Despite the increase, assist devices that are expected to aid healthcare delivery are not in abundance and could be as a result of standards imposed due to the sensitive condition of the subjects. Although closed loop control systems are expected to positively aid in that regards, the delicacy of the plant was a big constraint. An existing model from the works Ferrarin and Pedotti was elaborated from the knee swinging to the sit-to-stand movements and from the two mathematical models it can be inferred that even though similar higher level of excitation would be required for sit-to-stand manoeuvre. As part of research to improve on closed approach for the FES system, an appraisal was successfully done on the neuromuscular model together with fatigue models from the works on Lynch. The remodelled fatigue models to suit the research were presented.
Influence of body mass index and polycystic ovarian syndrome on ICSI/IVF treatment outcomes: A study conducted in Pakistani women

Background: Obesity may establish a crucial barrier for effective fertility treatment in polycystic ovary syndrome (PCOS) females. Objective: To compare results of intra-cytoplasmic sperm injection (ICSI) in females with and without polycystic ovarian syndrome and further appraise the effect of obesity in PCOS females. Materials and Methods: A cross-sectional study from June 2015 to July 2016 included non-PCOS and PCOS (recognized by Rotterdam criteria) females who underwent ICSI. The PCOS were further stratified into non-obese and Obese according to the South Asian criteria for body mass index. Results were categorized on the basis of beta-human chorionic gonadotropin (β-hCG) and transvaginal scan into non-pregnant (β-hCG <25 mIU/ml), preclinical abortion (β-hCG >25 mIU/ml with no fetal cardiac activity) and clinical pregnancy (β-hCG >25 mIU/ml with fetal cardiac activity on transvaginal scan). In addition, reproductive outcomes; implantation rate, clinical pregnancy rate and miscarriage rate among obese and non-obese PCOS and non-PCOS patients were compared. Results: Our results revealed 38.5% clinical pregnancy rate in non-PCOs females, 23.8% in non-obese PCOS females whereas 26.4% in obese PCOS. Preclinical abortions were found to be highest (31.5%) in non-obese PCOS females and were the lowest (26.2%) in non-PCOS females. In non-PCOS group and non-obese PCOS females 35.4% and 44.6%, respectively, failed to become pregnant. Conclusion: The success after ICSI in terms of number of clinical pregnancies was more in non-PCOS patients as compared to PCOS. Increase in body mass index reflected a negative impact on the reproductive outcome in PCOS patients.
Exploring suicide-related disclosure motivation and the impact on mechanisms linked to suicide

Abstract Suicide-related disclosure enables improved risk management but disclosure motivations are understudied. This study identified reasons for and against disclosing suicidal thoughts and examined their link to future disclosure and interpersonal needs among 44 people receiving psychiatric care. The most endorsed reasons for disclosure (approach-motivations) included help-seeking, shared background, and catharsis. The most endorsed reasons against disclosure (avoidance-motivations) included fear of rejection, shame, and hospitalization. Higher mean approach motivation was associated with more disclosure intent and less burdensomeness. No associations with avoidance motivation were observed. Programming that seeks to orient people toward approach motivation holds promise for attenuating suicide risk.
Non‐human primates as a reservoir for rabies virus in Brazil

Rabies virus (RABV) does not persist in the environment as it is a very fragile agent. The primary hosts are mammalian species in the orders Carnivora and Chiroptera. Since the late 1980s, RABV has been isolated from non‐human primates, Callithrix jacchus (the white‐tufted marmoset), in four coastal states (Rio Grande do Norte, Ceará, Piauí and Pernambuco) in north‐eastern Brazil, where this species is indigenous. The original habitat of C. jacchus consisted of two Brazilian biomes, the Atlantic Forest and the Caatinga. However, these marmosets have since adapted to other ecosystems as a result of human activities. Between 1988 and 1989, RABV isolates were obtained from white‐tufted marmosets in the state of Rio Grande do Norte, but antigenic and genetic identification studies were not conducted at that time. In the following years, three additional states reported cases (Ceará, Piauí and Pernambuco). In two of these states (Ceará and Piauí), human cases of rabies transmitted by marmosets were reported. According to Brazilian Health Ministry data, at least 19 human cases in which this species was the source of infection were registered in between 1990 and 2016. Recent findings in laboratory tests of 12 rabid samples from humans and marmosets and the regional transmission among these animals for over 20 years, together with the gradual increase in the affected geographic area, support the concept of the emergence of a new RABV reservoir. Regional tourism, the wild animal trade and the cultural practice of maintaining these animals as pets, particularly in coastal regions, appear to be major risk factors for the increase in human cases. Additional epidemiological and ecological studies are required to better understand local disease dynamics and to identify ideal opportunities for prevention and control of this fatal infection.
Le cas de la communauté de pratique en innovation pilotée par le Groupe SEB

Dans une ere de changement continu, les entreprises qui reussissent sont celles qui creent constamment de nouvelles connaissances et les diffusent largement au sein de toute l’entreprise pour les integrer ensuite dans de nouveaux produits, services ou procedes. Dans ce contexte, de nombreuses entreprises multinationales mettent en place des communautes de pratique qui favorisent l’apprentissage, le developpement et le partage des connaissances et conduisent a la creation d’un environnement propice a la creativite et l’innovation. Cette recherche vise a contribuer a une meilleure comprehension des processus de mise en place et de developpement d’une communaute de pratique en innovation. L’etude empirique, conduite au sein du Groupe SEB, concerne une communaute de pratique en innovation. Les donnees ont ete collectees a travers 63 entretiens semi-directifs, completes par une observation directe et l’analyse de documents internes. Les resultats obtenus mettent en exergue l’existence de quatre phases caracterisant la mise en place et le developpement d’une communaute de pratique.