Miracle-dz/UniFAR-FTUs huggingface dataset:
New prioritization function for user scheduling in OFDMA Systems

In this paper a new prioritization function for Orthogonal Frequency Division Multiple Access (OFDMA) is proposed where the resource allocation problem is divided in two phases, minimum requirements satisfaction, and spectral efficiency maximization. For each phase a different prioritization function is considered. The performance of the proposal is evaluated, via computer simulation, by the packet delay statistics obtained for different scenarios and also compared to other prioritization functions from the literature.
Therapeutic arteriogenesis has arrived.

The report by Seiler et al1 on a clinical trial using granulocyte-macrophage colony-stimulating factor (GM-CSF) to stimulate the growth of coronary collateral vessels is the temporary culminating point of a long history of research that started in the early 1940s with the observation that the pressure measured in the distal stump of an occluded canine coronary (or femoral or carotid) artery rose as a function of time and was caused by the development of a collateral circulation.2,3 Strandness4 and Schoop and Jahn5 were probably the first to measure the pressure in the distal stump of a peripheral artery in the leg of patients for an estimation of residual perfusion. See p 2012 Almost 30 years after Gregg, my group presented the first systematic analysis of peripheral coronary pressure (PCP), provided a theoretical framework, and described the influence of coronary collateral growth and of collateral blood flow on PCP.6 This led to the formulation of an electrical analog of the coronary arterial system that was later refined by Scheel et al7 and Harrison et al.8 The electrical analog could be displayed on an Apple Macintosh computer and served as a great educational aid for training young cardiologists and physiologists. This was necessary because the complex network of coronary resistances sometimes behaved counterintuitively, but the program helped solve problems of interpretation. A classic case of confusion to the uninitiated is the fall in PCP with increasing collateral blood flow and vice …
CD28‐mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28

JJ316 and JJ319 are rat CD28‐specific monoclonal antibodies (mAb) of the γ1χ isotype with identical co‐stimulatory potency. At a concentration 100–1000‐fold higher than that required for co‐stimulation, JJ316, but not JJ319 induces massive proliferation of all T cell subsets in vitro without T cell receptor (TCR) triggering. “Direct” stimulation by JJ316 is fully blocked by JJ319, indicating that it is not due to cross‐reactivity of JJ316 with the TCR complex or other activating receptors. JJ316 binds much more slowly to primary T cells than JJ319, whereas both antibodies bind with similar kinetics to CD28‐transfected L‐929 cells, suggesting that JJ316 binding to T cells requires redistribution or a conformational change of CD28. In vivo, JJ316 but not JJ319 induces rapid and transient proliferation of most CD4 T cells and, indirectly, of B cells. These data show that TCR engagement is not an absolute prerequisite either in vitro or in vivo for the induction of T cell proliferation through CD28 and suggest that mAb JJ316 is able to stimulate resting T cells directly by recruiting CD28 molecules from an inactive to an active form.
Escherichia coli protein analogs StpA and H‐NS: regulatory loops, similar and disparate effects on nucleic acid dynamics.

Expression of the Escherichia coli StpA protein was investigated and a functional comparison undertaken with the structurally analogous nucleoid protein H‐NS. Analysis of stpA and hns expression indicated that although stpA transcript levels are much lower than those of hns, the two gene products are capable of both negative autogenous control and cross‐regulation. Examination of cellular proteins in stpA, hns, or stpA‐hns backgrounds revealed that StpA can repress and activate a subset of H‐NS‐regulated genes. Mechanistic parallels in regulation of gene expression are indicated by the ability of both proteins to inhibit transcription from promoters containing curved DNA sequences, and to form nucleoprotein structures that constrain DNA supercoils. Despite their functional similarities, each molecule is capable of independent activities. Thus, H‐NS regulates a class of genes that are unaffected by StpA in vivo, whereas StpA has much stronger RNA chaperone activity in vitro. We therefore propose that in addition to its role as a molecular back‐up of H‐NS, StpA's superior effect on RNA may be exploited under some specific cellular conditions to promote differential gene expression.
Deletion of RBM and DAZ in azoospermia: evaluation by PRINS.

Molecular and cytogenetic studies from infertile men have shown that one or more genes controlling spermatogenesis are located in proximal Yq11.2 in interval 6 of the Y chromosome. Microdeletions within the azoospermia factor region (AZF) are often associated with azoospermia and severe oligospermia in men with idiopathic infertility. We evaluated cells from a normal-appearing 27-year-old man with infertility and initial karyotype of 45,der(X)t(X;Y)(p22.3;p11.2)[8]/46,t(X;Y)(p22.3;p11.2)[12]. By fluorescence in situ hybridization with dual-color whole chromosome paint probes for X and Y chromosomes, we confirmed the Xp-Yp interchange. By primed in situ labeling, we identified translocation of the SRY gene from its original location on Yp to the patient's X chromosome at band Xp22. We also obtained evidence that the apparent marker was a der(Y) (possibly a ring) containing X and Y domains, and observed that the patient's genome was deleted for RBM and DAZ, two candidate genes for AZF.
The role of Toll-like receptors in chronic B cell malignancies

Toll-like receptors (TLR) are key players in host defence from infection. They recognize a specific set of molecular patterns of microbial origin, immediately trigger an innate immune response, and bridge innate and adaptive immunity. TLR have also been shown to play a role in tumor development. In this context, chronic B-cell malignancies are an interesting example as clonal B lymphocytes remain responsive to and dependent on stimuli originating from the microenvironment which then become crucial for maintaining and propagating the disease. Emerging evidences suggest that, among other microenvironmental elements, TLR ligands may play a role in the pathogenesis of chronic B-cell lymphoid malignancies. Conceivably, their manipulation may find a place in specific settings of treatment of these tumors.
Net intergroup contact

The Net Intergroup Contact (NIC) platform is an Internet website located at http://www.intergroupconflict. com. It has been created out of the scholarship and experience acquired both from traditional Face to Face intergroup contact (F2F) and on online group interaction. NIC is an open invitation to people from different communities around the world to put an end to intergroup conflicts, through the use of online meetings that are conducted under the guidance of social psychologists.
Twin studies in psychotic disorders

etiology of major psychoses, particularly schizophrenia and bipolar disorder. Nevertheless, little is known about the nature and extent of the specific genetic contribution to disease liability (Kendler et al., 1993; Danese, 2008). Twin studies can provide crucial insights regarding the etiology of sub-threshold and clinical psychosis, and represent an extraordinarily powerful design to establish the role of genes and environment both in the expression of a trait (e.g., development of a disease) and in the co-expression of multiple traits (e.g., comorbidity of multiple diseases). By comparing the correlation for a trait between genetically identical monozygotic (MZ) twins with that between dizygotic (DZ) twins who represent full sibs, and assuming that MZ twins share relevant environmental exposures to the same extent as DZ twins (‘equal environments assumption’), it is possible to estimate the contribution of genetic factors (“heritability”) and environmental influences to the expression of the trait. Furthermore, when multiple phenotypes are studied, cross-twin/cross-trait correlation (i.e., between a given phenotype in a twin and another phenotype in his/her cotwin) in MZ and DZ twin pairs provides information on genetic or environmental influences common to the phenotypes (genetic or environmental correlation between the phenotypes), which could play a role in their coexpression (Boomsma et al., 2002; Spector et al., 2000). The potential of the twin design enormously increased after the implementation of population-based registries of data on twins in several countries (Busjahn & Hur, 2006), including Italy (Fagnani et al., 2006; Stazi et al., 2002). A large body of twin studies aimed at unraveling the genetic and environmental architecture of major psychoses and psychotic symptoms. Although results vary Twin studies in psychotic disorders
The Functional Topography and Temporal Dynamics of Overlapping and Distinct Brain Activations for Adaptive Task Control and Stable Task-set Maintenance during Performance of an fMRI-adapted Clinical Continuous Performance Test

Previous studies have demonstrated that stable and adaptive attention processes are mediated by partly overlapping, but distinct, brain areas. Dorsal medial PFC and anterior insula may form a “core network” for attention control, which is believed to operate on both temporal scales. However, both the existence of such a network as well as the unique functional topography for adaptive and stable attention processes is still highly debated. In this study, 87 healthy participants performed a clinical not-X continuous performance test optimized for use in a mixed block and event-related fMRI design. We observed overlapping activations related to stable and adaptive attention processes in dorsal medial PFC and anterior insula/adjacent cortex as well as in the right inferior parietal lobe and middle temporal gyrus. We also identified areas of activations uniquely related to stable and adaptive attention processes in widespread cortical, cerebellar, and subcortical areas. Interestingly, the functional topography within the PFC indicated a rostro-caudal distribution of adaptive, relative to stable, attention processes. There was also evidence for a time-on-task effect for activations related to stable, but not adaptive, attention processes. Our results provide further evidence for a “core network” for attention control that is accompanied by unique areas of activation involved in domain-specific processes operating on different temporal scales. In addition, our results give new insights into the functional topography of stable and adaptive attention processes and their temporal dynamics in the context of an extensively used clinical attention test.
Research on the Effect of Debt Financing in Electric Power Listed Company

This paper investigates the effect of debt financing in electric power listed company through an empirical research with the regression analysis method. According to the capital structure theory, the effect of debt financing lies in financial leverage effect, the tax shield effect and the company governance effect. Considering the characteristics of the electric power industry, we makes a detailed study relying on the data of electric power listed companies from 2004-2006, which belongs to the security markets of Shanghai and Shenzhen. The empirical results show that, for the companies with strong profitability, raising the debt ratio can contribute to the improvement of the effect of debt fiancing; for the companies with poor profitability, it will cause worse effect. These researches help to make suggestions for improving the effect of financing.
Relatives' experiences of everyday life when receiving day care services for persons with dementia living at home —"It's good for her and its good for us"

Relatives often become involved in the care of people with dementia who are living at home. The caregivers’ burdens are extensively described in several studies, and one of the most common, unmet needs of the caregivers is the opportunity for daytime activities. The aim in this qualitative study is therefore to explore the everyday lives of eight relatives of people with dementia who are receiving day care services. A content analysis is used, and three major themes emerge and are discussed: 1) when life becomes chaotic; 2) rebuilding a new, everyday life; and 3) the agonies of choice. The findings indicate that day care service offers respite care, and, at the same time, it gives both the relatives and those with dementia a meaningful day. These findings can also be described as relatives traveling a route from a situation characterized by chaos and suffering to a new life situation that has meaning through day care services. It is important to note that despite this new meaning in the relatives’ lives, the relatives continue to struggle with decisions about the futures of their loves ones in regard to the dilemma of placing them in an institution versus aging in place.
Major postpartum haemorrhage

Postpartum haemorrhage remains in the top five causes of maternal deaths in both developed and developing countries. Persistent blood loss of more than 1000 ml should prompt predetermined measures to achieve resuscitation and haemostasis. A protocol including guidelines is given and volume replacement is discussed. The range of medical and surgical interventions that may be considered for the modern management of major haemorrhage unresponsive to oxytocin and ergometrine are presented. The review discusses in depth the use of misoprostol, recombinant activated factor VII, the uterine tamponade procedures, artery ligation, and uterine haemostatic suturing techniques. It also evaluates the place of interventional radiology and hysterectomy in modern obstetrics.
Suppression of Atrial Ectopy with Intravenous Metoprolol in Chronic Obstructive Pulmonary Disease Patients

Abstract: To determine the efficacy of a cardioselective beta blocker in the treatment of atrial ectopy in patients with chronic obstructive pulmonary disease (COPD), we administered intravenous metoprolol (0.2 mg/kg) to six patients with atrial ectopic depolarizations (AEDs) and chronic partially reversible airflow limitation (FEV1 = 1.24 ± 0.21 liter, mean ± S.E.). Metoprolol reduced the mean frequency of AEDs from 713 ± 237 per hour to 218 ± 127 per hour. Furthermore, three of six patients experienced an 85 per cent or greater decrease in AEDs. No changes were observed in FEV1, FVC, or FEF25–75 over the course of the study. These data suggest that intravenous metoprolol is effective in reducing the frequency of AEDs and that it can be administered to patients with COPD without causing an increase in airflow limitation.
Physical dosimetry and mathematical dose calculation in nuclear medicine: A comparative study

Objectives: This paper addresses a comparison between physical dosimetry and mathematical dose calculation in nuclear medicine. Materials and Methods: Dose rate was calculated by mathematical external dose calculation formula and by physical dosimetry from the surface of 38 adult patients’ body referred to nuclear medicine department. Results of the methods were compared and correlation and regression tests were also performed. Results: Although the physical dosimetry data in this study are in good consistency with other researches, they are much lower than the results of mathematical dose calculation formula. The correlation coefficient between measured dose rate with calculated values derived by mathematical formula was found to be 0.852 (P value=0.148). Conclusion: It seems that physical dosimetry data are more accurate than the results of mathematical dose calculation. In case of using mathematical dose calculation formula, other correction factors should be considered and applied for getting reliable data.
Hepatocellular carcinoma occurring in nonfibrotic liver: Epidemiologic and histopathologic analysis of 80 French cases

Hepatocellular carcinoma (HCC) occurring in nonfibrotic liver represents a rare, ill‐defined subgroup of HCC without cirrhosis in which mechanisms of hepatocarcinogenesis remain unclear. The aim of our study was to assess epidemiological factors and detailed histopathologic changes in the nontumoral liver of patients developing such tumors. Of 330 HCCs resected in our institution between 1985 and 1998, we retrospectively analyzed 80 cases (53 men, 27 women; mean age, 51 ± 16 years) in which the nontumoral liver showed no (n = 28) or minimal (n = 52) portal fibrosis without any septal fibrosis. In the group with no portal fibrosis there was no male predominance, and patients were significantly younger (44 ± 19 years vs. 54 ± 14 years) than those with minimal portal fibrosis. Sixty‐seven tumors were typical HCCs, 8 were of fibrolamellar type, and 5 were hepatocholangiocarcinomas. Mean tumor size was 10 ± 5 cm. Risk factors for HCC development were found in 30 patients: hepatitis B (n = 17) or C (n = 2) virus infections, alcohol consumption (n = 11), and hemochromatosis (n = 1). In the nontumoral liver, periportal and lobular necrosis, mild portal inflammation, steatosis, and iron overload were present in 15%, 57%, 52%, and 54% of cases, respectively. Liver cell changes were noted in 6%. This study emphasizes the need for strict criteria to classify HCC without cirrhosis. HCC in nonfibrotic liver is a distinct subgroup in which nontumoral liver shows nonspecific minimal changes without regeneration or premalignant lesion. Etiologic factors are often unidentified, although presence of HBV infection in 21% suggests a direct oncogenic role of this virus.
A 3∼5-GHz low-phase-noise fractional-N frequency synthesizer with AFC for GSM/PCS/DCS/WCDMA tranceivers

A low-phase-noise Σ-Δ fractional-N frequency synthesizer for GSM/PCS/DCS/WCDMA transceivers is presented. The voltage controlled oscillator (VCO) is designed with modified digital controlled capacitor array (DCCA) to extend tuning range and minimize phase noise. A high-resolution adaptive frequency calibration (AFC) technique is proposed to choose frequency bands automatically in short time and increase phase noise immunity. A prototype is implemented in 0.13 μm CMOS technology. Experimental results show that the designed 1.2V wideband frequency synthesizer is locked from 3.05GHz to 5.17GHz within 30μs (20ppm), including 8μs AFC time. The measured in-band phase noise is −95.5 and −101dBc/Hz for 1.955GHz and 948MHz carriers, respectively, and accordingly the out-of-band phase noise is −123, −132dBc/Hz at 1MHz offset, and the reference spur is less than −69dBc.
ISSa 4-Based Differentiation of Streptococcus agalactiae Strains and Identification of Multiple Target Sites for ISSa 4 Insertions

ISSa4-Based Differentiation of Streptococcus agalactiae Strains and Identification of Multiple Target Sites for ISSa4 Insertions Alexander Dmitriev, Adong Shen, Xuzhuang Shen, and Yonghong Yang* Institute of Experimental Medicine, Academy of Medical Sciences, Saint Petersburg 197376, Russia, and Beijing Children s Hospital Affiliated to Capital University of Medical Sciences, Beijing 100045, People’s Republic of China
n individual-based quantitative approach for delineating core areas of animal pace use

Core areas are often employed in space-use studies to emphasize sections of a home range where an animal supposedly concentrates its time spent (i.e., areas of intense use). The area designated as the core is often subjectively selected based on aggregations of animal locations, thus not quantitatively repeatable, or selected based on arbitrary areas from a home range estimator, thus not biologically significant. We present an explicit ecological model of space use for objectively delineating areas of intense use, or core areas, based on further refining the definition of core area as the area within which an animal spends a maximum amount of time. Core areas were delineated using a time-maximizing function derived from kernel analyses. Essentially, we plotted utilization distribution area against volume and determined the point at which the slope of the line fitted to the data is equal to 1; this point represents a threshold where the proportional home range area begins to increase at a greater rate than the probability of use and the corresponding isopleth value defines the boundary of the core area; an animal’s time spent within this area is maximized relative to the periphery. We used summer locations from 60 adult female moose (Alces alces) to demonstrate our method. Moose core areas were bounded by the x̄ = 58% (SD = 0.60) isopleth and comprised x̄ = 77% (SD = 6.09) of animal relocations. Core areas represented x̄ = 27% (SD = 1.99) of the home range (x̄ = 3837 ha, SD = 4336.15; 95% utilization distribution) and were used an average of 2.16 (SD = 0.20) times more intensely than home range peripheries. Proportions of intensively used areas, as defined by isopleth values, were not related to home range size. Our technique reflects a biological understanding of a core area and provides a repeatable, quantitative method that enables statistical testing of hypotheses related to the effects of environmental factors on home range and core area size and usage. Adopting our approach will greatly improve our capacity to understand and ability to compare rce s spatial dynamics of resou
Selective targeting of the nuclear factor-kappaB pathway enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated pancreatic cancer cell death.

BACKGROUND Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor family, selectively induces apoptosis in various cancer cells; however, certain cancers can evade TRAIL-mediated apoptosis. FLICE-like inhibitory protein (FLIP), an inhibitor of caspase-8, (also known as FLICE) is regulated by the transcription factor nuclear factor-kappaB (NF-kappaB) and can contribute to TRAIL resistance. The purpose of our study was to determine whether inhibition of NF-kappaB can enhance TRAIL-mediated pancreatic cancer cell death and decrease FLIP levels. METHODS The human pancreatic cancer cell lines MIA PaCa-2 and L3.6 were treated with TRAIL, NEMO-binding domain (NBD) peptide (a novel selective NF-kappaB inhibitor), or a combination of both. Cell viability and apoptosis were measured. Gel mobility shift assays were performed to assess NF-kappaB binding activity. Western blots were performed to assess FLIP levels after treatment with NBD or infection with an adenovirus encoding mutated IkappaBalpha. RESULTS The aggressive L3.6 cell line was resistant to TRAIL treatment, whereas MIA PaCa-2 cells were sensitive to TRAIL. The combination of TRAIL and NBD significantly decreased cell viability and increased apoptosis in L3.6 cells. Cellular levels of FLIP were decreased by inhibition of NF-kappaB (either by NBD treatment or mutant IkappaBalpha infection). CONCLUSIONS Our findings demonstrate resistance of the aggressive L3.6 pancreatic cell line to TRAIL treatment alone; inhibition of NF-kappaB by NBD increased TRAIL-mediated cell death and decreased FLIP protein levels. Novel agents that selectively target the NF-kappaB pathway may be useful adjuvant therapies for chemoresistant pancreatic cancers.
A discrete fractional Fourier transform based on orthonormalized McClellan-Parks eigenvectors

A version of the discrete fractional Fourier transform (DFRFT) is developed with the objective of approximating the continuous fractional Fourier transform (FRFT). First the McClellan-Parks nonorthogonal eigenvectors of the discrete Fourier transform (DFT) matrix are generated analytically after deriving explicit expressions for the elements of those vectors. Second the Gram-Schmidt technique is applied to orthonormalize the eigenvectors in each eigensubspace individually. Third Hermite-like approximate eigenvectors are generated. Finally exact orthonormal eigenvectors as close as possible to the Hermite-like approximate eigenvectors are obtained by the orthogonal procrustes algorithm.