Miracle-dz/UniFAR-FTUs huggingface dataset:
Provable multiple replication data possession with full dynamics for secure cloud storage

Cloud storage has been gaining tremendous popularity among individuals and corporations because of its low maintenance cost and on‐demand services for the clients. To improve the availability and the reliability of critical data, storing multiple replicas on multiple servers is a commonly used strategy. Currently, several provable data possession (PDP) protocols for multiple replicas of dynamic data have been proposed to ensure the integrity of outsourced multi‐copy data, but the efficiency of these protocols on verifying multiple replicas one by one is not satisfactory. In this paper, we propose a provable multiple replication data possession protocol with full dynamics, named MR‐DPDP. In MR‐DPDP, we utilize a novel authenticated data structure called Merkle hash tree with rank to support both full dynamic data updates and efficient integrity verification. In addition, our construction with RSA signature can support both variable‐sized file blocks and public verification. Through security proof and performance evaluation, we demonstrate that MR‐DPDP not only is sound but also incurs less communication overhead when updating data blocks as well as verifying a proof of the integrity of multiple replicas. Copyright © 2015 John Wiley & Sons, Ltd.
Log-learning: A preliminary study

The paper presents a preliminary study of the log-learning approach. Reinforcement learning literature typically discusses tabula rasa agents. While not having to depend on prior knowledge in general is useful, in many cases more complex tasks prove intractable when no knowledge is communicated to the agent in advance. The log-learning approach presents a way to encode knowledge of useful partial behaviours. The approach is verified and experimental results are given. The paper concludes by suggesting some further steps of inquiry.
JSEA: A Program Comprehension Tool Adopting LDA-based Topic Modeling

Understanding a large number of source code is a big challenge for software development teams in software maintenance process. Using topic models is a promising way to automatically discover feature and structure from textual software assets, and thus support developers comprehending programs on software maintenance. To explore the application of applying topic modeling to software engineering practice, we proposed JSEA (Java Software Engineers Assistant), an interactive program comprehension tool adopting LDA-based topic modeling, to support developers during performing software maintenance tasks. JSEA utilizes essential information automatically generated from Java source code to establish a project overview and to bring search capability for software engineers. The results of our preliminary experimentation suggest the practicality of JSEA.
Causas moleculares de la hiperhomocisteinemia

Objetivo: revisar minuciosamente las investigaciones mas relevantes de las causas tanto geneticas como ambientales que explican el aumento de la concentracion de homocisteina en sangre (hiperhomocisteinemia). Fuentes: se realizo una busqueda en el Medline entre los anos 1962 y 1998 de las investigaciones relacionadas con las causas moleculares que inducen hiperhomocisteinemia tanto en animales de experimentacion como en humanos. Seleccion de las investigaciones: se encontraron 380 resumenes y de estos fueron seleccionadas 151 que identificaban las causas de hiperhomocisteinemia. Extraccion de los datos: los datos informados en esta revision fueron sacados de aquellos estudios experimentales cuyos objetivos y estrategias de investigacion permitian identificar algunas de las causas de hiperhomocisteinemia tanto en ayunas como despues de una sobrecarga oral de metionina. Resultados: estos estudios han permitido profundizar en el conocimiento del metabolismo de la homocisteina y desvelar algunas de las causas y mecanismos responsables del aumento de la homocisteina en sangre. Estas causas incluyen los factores geneticos que afectan la actividad de la enzima cistationina p-sintasa, la metilenotetrahidrofolato reductasa, la metionina sintasa o cualquiera de las enzimas involucradas en la formacion de una de las formas activas de la vitamina B12 (coenzima, metilcobalamina) o los factores ambientales que ocasionen una disminucion de la concentracion en sangre de acido folico, vitamina B6 o vitamina B12 En todos los casos, el aumento de homocisteina es proporcional al grado de alteracion de la actividad enzimatica o al deficit vitaminico. Conclusiones: la hiperhomocisteinemia puede ser detectada tras un analisis en ayunas y/o tras una sobrecarga de metionina. Estas determinaciones informan sobre la via metabolica afectada y permiten seleccionar la estrategia terapeutica por emplear.
The association of microalbuminuria and mortality in non-insulin-dependent diabetes mellitus. A systematic overview of the literature.

OBJECTIVES To critically analyze the literature linking microalbuminuria with total and cardiovascular mortality and cardiovascular morbidity in non-insulin-dependent diabetes mellitus (NIDDM) and to quantify the risk. METHODS A combination of retrieval techniques (MEDLINE, SCISEARCH, and handsearching published bibliographies) was used to find all relevant articles based on title and abstract and "Methods" sections. Unpublished data on albumin excretion rate were sought from large NIDDM cohort studies. RESULTS A total of 264 citations were retrieved, of which 11 cohort studies were selected for inclusion in the overview, representing a total of 2138 patients followed up for a mean of 6.4 years. Patient age was similar across cohorts. Duration of NIDDM ranged from newly diagnosed to 13 years. The prevalence of microalbuminuria ranged from 20% to 36% in the 8 cohorts that excluded patients with clinical proteinuria. All studies reported either a trend or a significant association between microalbuminuria and total mortality or cardiovascular morbidity or mortality; the overall odds ratio for death was 2.4 (95% confidence interval, 1.8-3.1) and for cardiovascular morbidity or mortality, 2.0 (95% confidence interval, 1.4-2.7). We found no evidence of reporting bias. CONCLUSION Microalbuminuria is a strong predictor of total and cardiovascular mortality and cardiovascular morbidity in patients with NIDDM.
Power transfer capacity improvements of existing overhead line systems

The increased demand for power transfer in combination with environmental and economic issues which set constraints to building new lines, force the implementation of new technologies into the existing system in order to improve its power capability. Such methods involve re-tensioning, re-conductoring, or modifying the tower design to utilize composite cross-arms. It is hypothesized that a composite cross-arm and a novel conductor together provide an insulating significant opportunity to increase the overhead line voltage. The paper explores the range of options that could be implemented on an L3 overhead line tower typically used at 275kV in the United Kingdom, and demonstrates clear improvement in power capacitiy through the implementation of new technologies.
Pathomorphosis of Cervical Cancer Stage IIB With the Applying of Preoperative Therapy

The article contains the results of study treatment the pathomorphosis squamous cell cervical cancer stage IIb using preoperative therapy. The study included 127 patients with cervical cancer stage IIB , of which 53 received preoperative course of external beam radiotherapy to 2 Gray to a total dose of 30 Gray with potentiation of cisplatin 40 mg/m2 weekly and 74 who applied neoadjuvant systemic chemotherapy according to the scheme FR (cisplatin 100 mg/m2, 5-fluorouracil 1000 mg/m2 from 1st to 4th day) 2-3 courses every 3 weeks, surgical intervention in the volume of panhisterectomy type III. The degree of therapeutic pathomorphosis of parenchymatous-stromal components was evaluated on a scale according to G.A. Lavnikova (1976). Methods of preoperative therapy that we used, led to the development of pronounced therapeutic pathomorphosis, especially in patients who received radiation therapy. Morphological and morphometric study of surgical specimens showed that therapeutic pathomorphosis after application of preoperative chemotherapy allows to achieve tumor devitalization. Consequently, the use of preoperative chemotherapy and radiation therapy are objective conditions for the realization of maximum possible effect of anti blastomic action, that corresponding the operating principles of ablation procedures.
A novel dopamine agonist for the transdermal treatment of Parkinson’s disease

Rotigotine is a non-ergot, enantio-selective, D3/D2/D1 dopamine (DA) agonist drug that is effective in classical models of Parkinson’s disease (PD), including the reserpinised mouse, the 6-hydroxydopamine-lesioned rat, and the MPTP-treated primate. It is active after oral administration but shows high clearance and a relatively short duration of effect. However, rotigotine is also effective after transdermal application in 6-hydroxydopamine-lesioned rats and MPTP-treated monkeys, in both of which the duration of effect is markedly enhanced. The pharmacologic properties of rotigotine suggest that it has the characteristics necessary to form the basis of a transdermal treatment for the control of motor symptoms of PD.
Zika Virus Outbreak, Bahia, Brazil

To the Editor: Zika virus (ZIKV) is a mosquito-borne flavivirus related to yellow fever virus, dengue virus (DENV), and West Nile virus (WNV). It is a single-stranded positive RNA virus (10,794-nt genome) that is closely related to the Spondweni virus and is transmitted by many Aedes spp. mosquitoes, including Ae. africanus, Ae. luteocephalus, Ae. hensilli, and Ae. aegypti. The virus was identified in rhesus monkeys during sylvatic yellow fever surveillance in the Zika Forest in Uganda in 1947 and was reported in humans in 1952 (1).
Notes et avis des consommateurs sur le web

Parmi les differentes sources d’information disponibles en ligne, les avis de consommateurs sont aujourd’hui tres couramment utilises. Ce dispositif de classement et de recommandation des biens et services se retrouve sur la plupart des sites de e-commerce mais egalement sur des plateformes dediees, generalistes ou specialisees (Ciao, Tripadvisor, Allocine, etc.). Il prend une forme relativement standardisee, combinant, modulo quelques variations, agregation de notes et commentaires rediges. A partir de l’observation de l’architecture de ces sites, du traitement de jeux de donnees collectees a cette fin et d’entretiens, l’article rend d’abord compte de la diffusion du dispositif « Note et Avis » en soulignant le mimetisme ou au contraire les amenagements specifiques etablis par les plateformes en fonction des equipements preexistants sur les marches. L’article analyse ensuite les differentes facons dont, sur le Web, la parole profane est mise en forme par le dispositif et s’articule ou entre en conflit avec les formes expertes de l’evaluation des produits. Une typologie est enfin proposee pour cartographier le monde des sites de Notes et Avis, a partir, d’une part, des caracteristiques des produits qui sont evalues et, d’autre part, de la nature de l’incertitude sur la(es) qualite(s) qui pese sur le consommateur dans sa phase de prospection.
The Intricacies of p21 Phosphorylation: Protein/Protein Interactions, Subcellular Localization and Stability

p21 was originally described as functioning as a cell cycle regulator via inhibition of both cyclin-dependent kinases and processive DNA replication. Nowadays it is recognised to play other fundamental roles including transcriptional regulation and the modulation of apoptosis. Each of these functions of p21 is achieved through direct p21/protein interactions and the subcellular localisation of p21 plays an important part in dictating the binding partners to which p21 is exposed. Over recent years, a number of phosphorylation sites in p21 have been identified, these being targeted by several important intracellular signalling protein kinases. Here we review the state of our knowledge of p21 phosphorylation with respect to the kinases involved and the molecular biological effects of each phosphorylation event.
L’influence des effets directs, non circadiens de la lumière et de la phototransduction mélanopsinergique sur l’humeur, la veille et le sommeil

Les troubles du sommeil et la depression ont une interaction fonctionnelle et constituent un enjeu majeur de sante publique. La lumiere influence la physiologie, le comportement, en particulier la locomotion, le sommeil et l’humeur, via des effets, circadiens (entrainement de l’horloge) et directs,non-circadiens. L’objectif de ce travail a ete de caracteriser les effets directs, non circadiens de la lumiere sur les comportements, et d’evaluer le role des differents photorecepteurs impliques. Des souris « melanopsin knockout » ont ete exposees a differents niveaux de luminance (<10 lux, 150 lux,600 lux) sans changer la phase du rythme circadien. Nos resultats montrent que l’intensite lumineuse influence l’humeur, le sommeil, et la locomotion et qu’a <10 lux, il existe une alteration de l’humeur et de l’homeostasie du sommeil. Ces effets sont principalement melanopsine dependants. Si elles sont confirmees chez l’homme, ces observations seront pertinentes pour optimiser les indications de la luminotherapie et l’utilisation de la lumiere dans notre societe.
A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen

Human papillomavirus type 16 (HPV16) plays a role in the development of a subgroup of head and neck squamous cell carcinomas (HNSCC). However, uncertainty exists about the true impact of HPV in this tumor type as conflicting reports have been published with prevalence rates from 0 to 100%. We aimed to find a detection algorithm of a biologically and thus clinically meaningful infection, applicable for high‐throughput screening of frozen and formalin‐fixed paraffin embedded (FFPE) specimens. By considering detection of HPV E6 oncogene expression in frozen biopsies as gold standard for a meaningful HPV infection, the value of several assays was evaluated on FFPE tumor specimens and sera of 48 HNSCC patients. The following assays were evaluated on FFPE tissue samples: HPV DNA general primer (GP)5+/6+ PCR, viral load analysis, HPV16 DNA FISH detection, HPV16 E6 mRNA RT‐PCR, p16 immunostaining, and on corresponding serum samples detection of antibodies against the HPV16 proteins L1, E6 and E7. Comparing single assays on FFPE tissue samples detection of E6 expression by RT‐PCR was superior, but application remains at present limited to HPV16 detection. Most suitable algorithm with 100% sensitivity and specificity appeared p16 immunostaining followed by GP5+/6+ PCR on the p16‐positive cases. We show that clinically meaningful viral HPV infections can be more reliably measured in FFPE HNSCC samples in a standard and high throughput manner, paving the way for prognostic and experimental vaccination studies, regarding not only HNSCC, but possibly also cancer types with HPV involvement in subgroups such as penile and anal cancer. © 2007 Wiley‐Liss, Inc.
Reduced relapse rate in upfront tandem autologous/reduced-intensity allogeneic transplantation in multiple myeloma only results in borderline non-significant prolongation of progression-free but not overall survival

Results of Allogeneic Stem Cell Transplantation (Allo-SCT) as part of first-line therapy for multiple myeloma (MM) are conflicting. [1][1]–[7][2] The 96 month long-term followup of the EBMT trial showed a significantly prolonged PFS and OS for Auto-/Allo-SCT as compared to double Auto-SCT, both in
Brain Abscesses Due to Aspergillus nidulans Infection During Induction Chemotherapy for Acute Lymphoblastic Leukemia

We present the case of a 3-year-old boy who was diagnosed with cerebral abscesses due to Aspergillus nidulans infection on day 28 of induction chemotherapy for acute lymphoblastic leukemia. He responded well to treatment with voriconazole and caspofungin, making a full recovery. There are very few cases of invasive aspergillosis reported in children during induction chemotherapy for acute leukemia and A. nidulans is rare in the absence of chronic granulomatous disease.
Gonadotropin-releasing hormone analogue plus hormone replacement therapy for the treatment of endometriosis: a randomized controlled trial.

OBJECTIVE The aim of this study was to determine whether or not continuous combined HRT used with GnRH-a for the treatment of endometriosis can prevent hypoestrogenic side effects associated with GnRH-a. METHODS Forty premenopausal women with laparoscopically proven endometriosis entered the study. The patients were randomized into two groups. Group I (n = 19) received 3.75 mg i.m. leuprolide acetate (LA) every 4 weeks for 24 weeks. Group II (n = 21) received 3.7 mg LA combined with 1.25 mg oral conjugated equine estrogen (CEE) and 5 mg oral medroxyprogesterone acetate (MA). RESULTS Total revised AFS score as well as total pelvic pain scores decreased significantly (P < .001) in both groups. However, a statistically significant difference of hot flushes and sweating was reported by women receiving LA + HRT as compared to those treated with LA alone (P < .001). Furthermore, the bone loss at the lumbar spine was 4.2% in group I compared to 0.9% in group II at the end of the study. CONCLUSIONS This study suggests that 1.25 mg CEE + 5 mg MA is effective in preventing hypoestrogenic side effects caused by GnRH-a, while the treatment of endometriosis is not impaired.
The relationship between in vivo emptying of the gallbladder, biliary pain, and in vitro contractility of the gallbladder in patients with gallstones: is biliary colic muscular in origin?

BACKGROUND This study sought to determine whether there is a positive correlation between gallbladder emptying, biliary pain, and in vitro contractility. METHODS Ultrasound measurements were carried out on 25 gallstone patients. The response of gallbladder strips to 1.75*10(-11) to 5.25*10(-7) M cholecystokinin-8 was recorded. In a second study 23 patients filled in pain questionnaires, and in vitro studies were again carried out. RESULTS Of five patients with no gallbladder emptying, four had in vitro contraction. Overall, a significant, positive linear correlation was found (P < 0.0001). In the second study in vitro contractility showed a positive linear correlation with pain. CONCLUSION Gallbladder emptying correlates with contractility. However, since most 'non-contractors' can contract, we suggest the term 'non-emptying' or 'emptying' to describe gallbladder dynamics. The positive correlation between pain and contractility suggests that biliary pain has a muscular component.
Automated Molecular Library Generation of Proteic Fragments by Virtual Proteolysis for Molecular Modelling Studies

This paper presents a computer aided design method useful for simulation of a set of proteolytic cleavages upon target proteins obtained from the Brookhaven Data Bank. The method was developed by using algorithms that are able to interface themselves with other software environments, in order to assist computer analyses in the molecular modelling field, and allowing the generation of molecular libraries containing protein fragments produced by simulated proteolysis. These libraries include structures that differ for several amino acid deletions upon specified regions of the primary sequence. Target residues chosen for the simulation are compatible with enzymatic proteolysis methods used in conventional laboratory procedures. Furthermore, algorithms were able to identify a set of chemical-physical properties of the starting proteins, leading the simulation to find out the most suitable residues for proteolysis. The goal of these strategies is to generate fragments that are leaded to maintain the native-like condition of starting molecules, avoiding loss of conformational characteristics of the original tertiary structure. Proteins chosen for generating proteolytic libraries were represented by naphthalene 1,2 dioxygenase and Rigidoporus lignosus laccase.
Residual Stress Generation in Brazed Tungsten Dissimilar Joints

Understanding the residual stress state in brazed joints is crucial for the operational design and lifetime performance of the part in service. High-magnitude residual stresses are expected in the joined materials following cooling from brazing temperatures (≈ 950 °C) due to large mismatches in the thermal and mechanical properties. This paper aims at further understanding of the residual stresses caused when brazing tungsten to copper and tungsten to 316L austenitic steel using a eutectic gold-copper brazing alloy. These configurations are potentially useful for future diverter designs. Finite element analysis has been used to predict the brazing-induced stresses and residual stress measurements were carried out on the brazed joint by X-ray diffraction to validate the prediction model. Large residual stresses are predicted and measured in the tungsten; however, there is disagreement in the nature of the stress in the tungsten-copper configuration. Predicted stresses are highly tensile in nature close to the brazing interface, whereas the measured stresses are highly compressive. The disagreement is believed to be caused by the model not accurately simulating the complex brazing process. Residual stress measurements on the copper were not possible due to texturing during brazing, grain growth, and significant inelastic strains. There is excellent correlation between the measured and predicted stresses in the tungsten-316L configuration. High-tensile stresses were predicted in the tungsten (magnitude approximately 1000 MPa close to the braze interface) and high tensile stresses were measured (magnitude approximately 800 MPa in the same region). Joint misalignment of parent materials was also observed to significantly affect the residual stresses.
Classification of Polyene Antibiotics According to Chemical Structure and Biological Effects

Fourteen polyene antibiotics and six of their semisynthetic derivatives were compared for their effects on potassium (K+) leakage and lethality or hemolysis of either Saccharomyces cerevisiae or mouse erythrocytes. These polyene antibiotics fell into two groups. Group I antibiotics caused K+ leakage and cell death or hemolysis at the same concentrations of added polyene. In this group fungistatic and fungicidal levels were indistinguishable. Group I drugs included one triene (trienin); tetraenes (pimaricin and etruscomycin); pentaenes (filipin and chainin); one hexaene (dermostatin); and one polyene antibiotic with unknown chemical structure (lymphosarcin). Group II antibiotics caused considerable K+ leakage at low concentrations and cell death or hemolysis at high concentrations. The fungistatic levels were clearly separable from fungicidal. This group included the heptaenes (amphotericin B, candicidin, aureofungin A and B, hamycin A and B), and five of their semisynthetic derivatives (amphotericin B methyl ester, N-acetyl-amphotericin B, hamycin A and B methyl esters, and N-acetyl-candicidin). Nystatin, classified as a tetraene, and its derivative, N-acetyl nystatin, also were in this group.