Miracle-dz/UniFAR-FTUs huggingface dataset:
CD 98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap 1

CD98 is a multifunctional heterodimeric membrane protein involved in the regulation of cell adhesion as well as amino acid transport. We show that CD98 cross-linking persistently activates Rap1 GTPase in a LFA-1-dependent manner and induces LFA-1/ICAM-1-mediated cell adhesion in lymphocytes. Specific phosphatidylinositol-3-kinase (PI3K) inhibitors suppressed both LFA-1 activation and Rap1GTP generation, and abrogation of Rap1GTP by retroviral overexpression of a specific Rap1 GTPase activating protein, SPA-1, totally inhibited the LFA-1/ICAM-1-mediated cell adhesion. These results suggest that CD98 cross-linking activates LFA-1 via the PI3K signaling pathway and induces accumulation of Rap1GTP in a LFA-1-dependent manner, which in turn mediates the cytoskeleton-dependent cell adhesion process. ß 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
ii Insider trading and voluntary nonfinancial disclosures

Voluntary nonfinancial disclosure of product and business expansion plans occurs frequently in practice and is an important vehicle by which managers convey corporate information to outsiders, but little is known about how managerial opportunistic incentives affect the choice of such nonfinancial disclosures. This study examines whether managers strategically time, and make selectivity in, their voluntary nonfinancial disclosures for selfserving trading incentives. Accounting for the endogeneity between disclosures and insider trades, I find strong and robust evidence that insiders manipulate the timing and selectivity of their nonfinancial disclosures to maximize trading profits. In particular, managers tend to disclose bad (good) news on product or business expansion information before purchasing (selling) shares. Overall, the results contribute to understanding managers’ use of nonfinancial disclosure strategies for fulfilling personal trading incentives, and should be of interest to boards of directors, which monitor and restrict opportunistic disclosures and insider trading within a firm.
Syntactic Properties of Legal Language in English and Albanian

Being the primary means of communication worldwide, English has become a career tool for all categories of professionals, including lawyers, as it allows them to communicate internationally. English Legal documents are one of the objects of a lawyer’s routine since they write and interpret English-based contracts and other important documents, which may be complex and also include technical vocabulary. Legal terminology and grammar for non-native speakers of English language may bring difficulties. This article is a cross-linguistic study which describes the typical linguistic features of legal English, focusing on syntactic constructions, and aims to make it more comprehensible not only to those studying it, but to teacher of legal English at the same time. It will mainly deal with the pragmatic aspect of language in a synchronic approach. Such characteristics will be presented using a comparative descriptive perspective, between English and Albanian language. We will mainly focus on grammatical features of instructional language used in English legal documents such as the use of performative verbs and speech acts, performative utterances, verb form, finite verbs, passive forms, subjects and objects etc., comparing them to the Albanian equivalent ones.
Private Channels in Wireless Local Networks

Summary This paper presents a modified version (DHBT-E) of an existing two-party key agreement protocol (DH-BT) used for efficiently establishing secure communication sessions in local wireless networks. A formal security analysis in the model of Bellare and Rogaway is provided to justify the relevant security properties and thus to enforce trustworthiness. The basic intuition is that key agreement in open-air-networks should provide forward secrecy, since eavesdropping is essentially for free and hence may give the adversary a small but significant advantage. For this reason, the protocol uses basic Diffie-Hellmann key exchange. Entity authentication is based on the shared string model, with the key formed by two cryptographic component keys (one key being eventually a low-entropy human memorable string), thus guaranteeing a stronger (two-factor) level of security.
The Scientific Building Blocks of PeaceBuilders Nine Key Principles of the Science of PeaceBuilding

This key principle is supported by Dr. Donald Baer, who argued that children’s behavior is always functional in the conditions they face. Dr. Dennis D. Embry’s work with children of deployed military parents during the Gulf War revealed that up to 40% of these children had significant behavior changes1 such as increased fighting, fears, distractions, restlessness, nightmares, and sleeping problems. More of these children engaged in risk behaviors such as the use of tobacco, alcohol, drugs and early sexual behavior. Rather than view these behavior changes as symptoms of mental illness, Dr. Embry concluded that these behaviors were adaptations to a world that was perceived to be filled with predatory adult humans in a violent world. Some of Dr. Embry’s students challenged him to write a book on how to build peace. He reread classic studies and phoned many scholars to seek understanding of what might be done. He began the collaborative work of applying these scientific principles in order to create a more peaceful world.
Development of Broadband Class E Power Amplifier for WBAN Applications

In this paper, a Class E Power Amplifier (Class-E PA) suitable for Wireless Body Area Networks (WBAN) is proposed. A commercially available RF3931 GaN (gallium nitride) high electron mobility transistor deviceis used in the proposed design, together with an active harmonic load–pull analysis of the class E mode. The proposed PA utilizes a band pass filter matching network and operates in the frequency range of 6.78MHz to 2.2GHz. The designed PA is fabricated in FR4 substrate and the measurement results are provided. The designed PA provides 78.5% of maximum power efficiency with a fractional bandwidth of 40 while achieving the gain of 10.8-to14.8 dB. The maximum output power achieved is 42.9 dBw.
Influenza's Response to Climatic Variability in the Tropical Climate: Case Study Cuba

This paper is aimed to assess Zika virus (ZIKV) spatiotemporal historical distribution, the potential mechanisms and contributing risk factors for epidemic emerging, the attempt to mitigate, and its future aspect. Available literature from the years 1900 to 2018 were assessed and compiled. Previous analyses on the partial structural envelope as well as the non-structural proteins gene sequences suggests the occurrence of ZIKV strains ancestor erstwhile in the beginning of 1900s in Uganda. Infection with the virus was also first reported in Uganda since 1947. It gradually distributed to different countries in the world until the present 2018. It was found that ZIKV has multifactorial health challenges from several corners. Its epidemiology has wide reservoirs, susceptible and vector hosts, and different mode of transmission. The potential mechanisms of epidemic occurrences are viral evolution changes in mosquito, presence of human viremia and immunity in endemic exposures, and stochastic introduction to new areas. Moreover, climate change which disrupts health security and sociology-economy favors vector mosquito make ZIKV adaptation and causes global emerging epidemics. Presence of global travel with possibility of human-to-human transmission, urban area preference of the vector mosquito, and climate change adaptation of both the virus and the vector are core current risk for the epidemic. Presence of crossreactors, absence of both therapeutic drug and vaccine (the only promising future vaccine being ZIKV sub-unit recombinant biotechnology) were exacerbating the risk of Zika infections. The present sole preventive strategy is vector control. Therefore, defined and prioritized research on the epidemiology, diagnostic techniques, therapeutic drug and preventive vaccine development are recommended. Burst feed transmission should be checked. Capacity building on diagnostic laboratories and risk communication are relevant for developing countries.
Performance & Power Impact of Multiple DRAM Address Mapping Schemes: The Performance and Power Impact of Using Multiple DRAM Address Mapping Schemes in Multicore Processors

Lowest-level cache misses are satisfied by the main memory through a specific address mapping scheme that is hard-coded in the memory controller. A dynamic address mapping scheme technique is investigated to provide higher performance and lower power consumption, and a method to throttle memory to meet a specific power budget. Several experiments are conducted on single and multithreaded synthetic memory traces -to study extreme cases- and validate the usability of the proposed dynamic mapping scheme over the fixed one. Results show that applications performance varies according to the mapping scheme used, and a dynamic mapping scheme achieves up to 2x increase in peak bandwidth utilization and around 30% higher energy efficiency than a system using only a single fixed scheme Moreover, the technique can be used to limit memory accesses into a subset of the memory devices by controlling data allocation at a finer granularity, providing a method to throttle main memory by allowing un-accessed devices to be put into power-down mode, hence saving power to meet a certain power budget.
A Study on Random Access Performance in Next Generation Mobile Network Systems

The next generation of mobile telecommunication, 5G, will be specified in the near future. One of the proposed changes relative to the previous generation, 4G, is the inclusion of a new system control plane (SCP). The purpose of the SCP is to improve system scalability, forward compatibility, peak performance and to enable a higher degree of support for advanced antenna techniques. This is done by logically separating data transmitted explicitly from and to the user, the dynamic transmissions, from the broadcasted transmissions that remain constant regardless of user activity, the static transmissions, and by then redesigning the static part to make it more lean. This is expected to have several positive effects such as considerably more free resources, resulting in energy savings and potentially increased usage of MIMO. Knowing what effect the SCP has upon aspects such as random access is of importance when designing the solution that will go into the standard. Simulations show that there is potential in the inclusion of the new SCP. While the simulated 5G candidate systems that include the SCP have an increased delay when running the random access procedure, some aspects of the procedure have been improved. The main differences relative to the simulated 4G system are the performance of the first message in the procedure, which increased, and the performance of the second message in the procedure, which decreased. The deficiencies found in the handling of the second message, however, can be alleviated by using a more proper algorithm and channel design than what was used in this study.
A NON-DIMENSIONAL FE MODEL FOR THE SIMULATION OF HEAT CONDUCTION IN CONCRETE

The simulation of heat conduction in concrete is fundamental to the assessment of the long-term performance of structural elements under the conditions of service. The phenomenon is conventionally described using a partial parabolic differential equation with thermal diffusivity as the transport parameter. Under ambient conditions, the thermal diffusivity value for concrete remains practically constant and hence the governing model is often taken to be linear. This study develops a non-dimensional form of the model to achieve computational efficiency and stability. The developed model subjected to constant temperature boundary conditions, has been subsequently analysed with a one-dimensional FE scheme based on a lumped mass matrix model developed through Galerkin’s technique. The algorithm has been implemented through a C++ programme to simulate the evolution of temperature distribution in a dry concrete medium with siliceous aggregates. The effect of different thermal gradients (60-25, 40-25, 20-25, and 0-25°C) on the attainment of steady state over a medium length of 0.1 m has been evaluated. The comparison of the simulated steady state temperature profiles against standard analytical solution verifies the reliability of the developed scheme.
Synthesizing Affect with an Analog Vocal Tract : Glottal Source

An analog speech synthesizer is constructed based on the sourcefilter model of the human vocal tract. The artificial tract was developed in part for studies on emotional and paralinguistic content in speech synthesis and for eventual studies on speech interaction. In this study, the glottal open quotient (OQ) of the waveforms generated as the source (weak to strong high frequency spectrum), the fundamental frequency (F0), and a jitter parameter were varied as the filter shape or tongue posture was randomly altered. Subjects were first asked to rate caricature facial expressions on affective attributes and then to rate goodness of fit between the faces and the sound stimuli. Association scores between attributes and sounds based on these ratings were calculated. Results indicate that in the context of isolated sound segments, OQ is the strongest determinant of perceived android arousal and F0 is the strongest determinant of perceived android valence. Further results point to dependencies between the three varied parameters. Findings are consistent with related research and help to establish a foundation for future work with the artificial tract. A concluding discussion remarks on how this study and the project itself speaks to other research on speech and to android science in general. The rich visual cues and the more ecologically realistic acoustic radiation characteristics of an analog synthesizer are strategic to a science where naturalistic mechanisms for social interaction are needed.
or A d ? Readers ’ Recognition and E valuations of Native Advertisements on Online News Websites

The online media and advertising landscape has quickly changed in the past few years, and both media and advertisers are facing several major challenges. Consumers are more trained than ever to ignore traditional banner advertisements (Hill, 2013), and the amount of internet users with an ad blocker have been going up fast (Adobe, 2015). At the same time, from the media’s side, online news outlets increasingly rely on advertising to generate revenue, as most readers refuse to pay subscription fees to read online news (Newman, Fletcher, Levy, & Nielsen, 2016). Consequently, both media and advertisers are searching for alternative ways to deliver their message to their target audiences. Following this, so-called ‘native advertisements’ are an emerging phenomenon on online news websites (Filloux, 2013). With native advertising, advertisers are trying to reach the ad-avoiding news readers by delivering advertisements that mimic the style and content of editorial news articles (Wojdynski & Evans, 2015). Currently, almost all major news media are offering native advertising as part of their digital advertising mix (Einstein, 2016). It has been argued that native advertisements are positively evaluated due to their ‘editorial value’ and ‘non-intrusiveness’ (Campbell, 2015). Yet, critics are stressing the deceptiveness of native advertisements, and are warning news media for the long-term negative consequences of making the line between advertising and editorial content less clear (Carlson, 2014). Without a doubt, the preservation of news media’s credibility is important to both news media and advertisers, as credibility, autonomy and trustworthiness are the main reasons for readers to visit news platforms (Baker, 2001). Advertisers are also taking benefit of publishing on credible platforms, as this credibility could spill-over on readers’ evaluations of their advertisements (Bronner & Neijens, 2006; Van Reijmersdal, Neijens, & Smit, 2010). Therefore, native advertisements should be thoughtfully implemented. Nevertheless, little research has been conducted on readers’ evaluations of the advertising technique, and direct consequences for the news media are yet understudied. Although some research showed that native advertisements are positively evaluated and do not harm the credibility of the news website, the authors were not sure whether this was because readers liked the advertising
TNF-α correlates oxidative stress-induced cardiomyopathy: A comparative study among Indian male and female diabetic patients

Diabetic cardiomyopathy (DCM) is common disorder of the heart muscle and it contributes significantly to cardiovascular related death in the diabetic population. Oxidative stress plays a significant role in the development of diabetic cardiomyopathy. Tumour necrosis factor (TNF-α) which is increasingly expressed in the failing heart and in blood may stimulate oxidative stress. Objective: we investigated the relationship of TNF-α with oxidative stress in well and poorly controlled type-1 & type-2 diabetic cardiomyopathic Indian male and female subjects. Material and Methods: We measured plasma TNF-α, blood HbA1C & oxidative markers (MDA, SOD,) in the remnants samples, which come in lab for various investigations and collect ECHO data for the same subjects from various heart clinics.
Novel Approach to Query Expansion Using Genetic Algorithm on Clustered Query Sessions for Effective Personalized Web Search

Research has been done based on query expansion to bridge the gap between vocabulary of user search query and documents relevant to user in order to retrieve relevant documents early in search results. In this paper novel approach is proposed for recommending optimal set of terms for query expansion using genetic algorithm based on clustered query sessions. The genetic algorithm is applied on clustered query sessions for user input queries optimization in order to identify the optimal set of expansion terms relevant to the domain of cluster. The initial input query issued for search on the web is used to select the cluster for recommending the set of terms for query expansion. The process of retrieval of web search results using input query expanded with the selected terms along with the recommendations of next set of query terms for query expansion continues till the search is personalized according to the information need of the user. Experiment was conducted on the data set of query sessions captured on the web in three domain Academics, Entertainment and Sports and results show the significant improvement in the precision of search results using the proposed approach. Keywords— Information Retrieval, Personalized Web Search, Genetic Algorithms, Search engines, Query Expansion.
Multiple time scale sliding mode control of reusable launch vehicles in ascent and descent modes

A reusable launch vehicle control problem during ascent and descent is addressed via multiple-time scaled continuous sliding mode control. The proposed sliding mode controller utilizes a two-loop structure and provides robust decoupled tracking of both orientation angle command profiles and angular rate command profiles in the presence of bounded external disturbances and plant uncertainties, including aerodynamic surfaces and engine failures. Sliding mode control causes the angular rate and orientation angle tracking error dynamics to be constrained to linear, decoupled, homogeneous, and vector valued differential equations with desired eigenvalues. The dual-time scale sliding mode controller was designed for the X-33 technology demonstration sub-orbital launch vehicle in the ascent and descent modes. Simulation results show that the designed controller provides robust, accurate, decoupled tracking of the orientation angle command profiles in ascent and descent in presence of external disturbances and vehicle inertia uncertainties. The designed robust controller is to significantly reduce the time and cost associated with flying to new orbits, with new payloads, and with modified vehicles.
Characterization of Dye Sensitized CdSe Quantum Dots

The generation of dye sensitized solar cell (DSSC) and quantum dot-sensitized solar cells (QDSSCs) is considered as the third generation of the solar cell. Cadmium selenide (CdSe) is commonly used as n-type semiconducting layer for heterojunction thin film solar cells. In the present work, synthesis of nanoparticles of CdSe has been done using chemical precipitation technique. And extract dye from pomegranate fruit as the natural dyes. Co-sensitization by using two or more sensitizers with complementary absorption spectra to expand the spectral response range is an effective approach to enhance device performance of quantum dot sensitized solar cells (QDSSCs). To improve the light-harvesting in the visible/near-infrared (NIR) region, CdSe quantum dots (QDs) was combined with pomegranate dye for co-sensitized solar cells. The prepared CdSe QDs were characterized by UV–Vis absorption, and PL spectra. The CdSe quantum dots were prepared successfully of size 2.9 nm synthesized used LEEH as a capping agent. The size of nanoparticles in pomegranate dye found to be 8.99nm. The proposed solution have been characterized by, UVVisible spectra and photoluminescence studies. The size of nanoparticles is estimated from Yu model. When CdSe quantum dots are combined with dye, CdSe shows absorption from 387nm to 530nm. KeywordDye Sensitized Solar Cells, PL Spectra, Quantum Dots, Quantum Confinement, UV Absorption __________________________________________________________________________________________________
EXPERIMENTAL EVALUATION OF QUERY REFORMULATION TECHNIQUES IN THE CONTEXT OF MEDICAL INFORMATION RETRIEVAL

With the proliferation of online medical information, a majority of laypeople (ordinary people with little medical background knowledge) and medical specialists now find the Web an indispensable tool for searching for medical information in various domains of interest. However, when using existing medical search engines, the precision of the retrieved results is governed by two main factors. First, users (be they laypeople or medical professionals) need to submit vocabularies that best describe their information needs. Second, the quality of the returned results is largely based upon the effectiveness of the techniques and medical knowledge resources that are exploited by such search engines. Several systems and approaches have been proposed to address problems associated with each of these factors independently; however, little attention has been paid to cooperatively address problems of both factors. In this article, we aim to investigate the impact of exploiting medical knowledge resources and information retrieval techniques on 1) reformulating medical queries through enriching them with semantically-related medical terms and 2) indexing documents in the medical domain to improve the matching process between the reformulated queries and their corresponding medical documents. A prototype of the proposed system has been instantiated and experimentally validated using CLEF2014 eHealth Dataset and state-of-the-art effectiveness indicators. The produced results by our system demonstrate that the quality of the returned results has improved compared to other similar medical information retrieval systems.