Miracle-dz/UniFAR-FTUs huggingface dataset:
Short Communication Absence of Human Papillomavirus in Tonsillar Squamous Cell Carcinomas from Chinese Patients

Epidemiological and experimental evidence from Western countries now consistently support an etiological role for human papillomavirus (HPV) in a subset of oropharyngeal squamous cell carcinomas (SCC), especially those originating in the tonsil. The role of HPV in the etiology of tonsil cancer in developing countries such as China has not been investigated. In this study, none of 16 tonsil cancer specimens from Chinese patients were positive for HPV DNA, whereas those from Australian patients using the same methodology gave a positivity rate of 46%. The tumors from Chinese patients, like the Australian HPV-negative subset, significantly overexpressed pRb and cyclin D1 and underexpressed p16 INK4A (p16). In contrast, the Australian HPV-positive cancers overexpressed p16 and had reduced expression of pRb and cyclin D1. These findings may help explain why China has a relatively low rate of oropharyngeal cancer compared with Australia. They also support the hypothesis that molecular pathways to tonsil cancer mediated by HPV are distinct from those induced by mutagens present in cigarette smoke or alcohol. (Am J Pathol 2003, 163:2185–2189)
Rotating Out-of-Plane Micromirror

Out-of-plane micromirrors have been developed for a wide range of applications including optical switching, beam steering, and precise transmission and reception of bio-optical signals. This paper focuses on the design, simulation, and testing of a rotating out-of-plane micromirror. The system consists of a polysilicon micromirror, which is erected to an out-of-plane position using a relatively simple postprocessing procedure. The mirror is mounted on a gear which has a rotational freedom of 360° and can be driven at frequencies ranging from 1 to 1000 Hz using an electrostatically actuated rotational drive. Multiple out-of-plane configurations of the mirror are possible, with each utilizing a serpentine spring that attaches the mirror to the gear and a position specific ¿catch block¿ to allow 30 °, 45° , 60°, 75°, and 90° orientations of the mirror. This paper focuses on the 45° out-of-plane mirror, and it was tested for robustness as well as optical performance. A good correlation was found between experiment and various simulations.
Reconfigurable and parallelized network coding decoder for VANETs

Network coding is a promising technique for data communications in wired and wireless networks. However, it places an additional computing overhead on the receiving node in exchange for the improved bandwidth. This paper proposes an FPGA-based reconfigurable and parallelized network coding decoder for embedded systems especially for vehicular ad hoc networks. In our design, rapid decoding process can be achieved by exploiting parallelism in the coefficient vector operations. The proposed decoder is implemented by using a modern Xilinx Virtex-5 device and its performance is evaluated considering the performance of the software decoding on various embedded processors. The performance on four different sizes of the coefficient matrix is measured and the decoding throughput of 18.3 Mbps for the size 16 × 16 and 6.5 Mbps for 128 × 128 has been achieved at the operating frequency of 64.5 MHz. Compared to the recent TEGRA 250 processor, the result obtained with128 × 128 coefficient matrix reaches up to 5.06 in terms of speedup.
Angular dependence of scattered light, rotary frictional coefficients, and distribution of sizes of associated oligomers in solutions of bovine liver glutamate dehydrogenase

The angular dependence of scattering in solutions of bovine liver glutamate dehydrogenase was studied in 0.2M Na‐phosphate buffer, pH 7, 10−4M EDTA, and in buffered solutions saturated with either toluene or benzene. Whereas the shape of the scattering curves is in qualitative accord with the previously reported polymerization to rodlike linear structures, quantitative agreement between the calculated and experimental curves is poor when the polydispersity consistent with the association mechanism (derived from molecular weight determinations by light scattering and equilibrium sedimentation) is properly taken into account. The measurement of rotary frictional coefficients of macroscopic models of linearly associated glutamate dehydrogenase oligomers allowed the calculation of intrinsic viscosities of enzyme solutions but did not permit discrimination, by hydrodynamic means, between systems with different distributions of length.
Charge carrier transfer in tungsten disulfide—black phosphorus heterostructures

Photocarrier dynamics in tungsten disulfide—black phosphorus (BP) heterostructures were studied by time-resolved differential reflection measurements. The heterostructures were fabricated by stacking together monolayer WS2 and BP flakes that are both fabricated by mechanical exfoliation. Efficient and ultrafast transfer of photocarriers from WS2 to BP flakes was observed. This confirms the type-I band alignment of WS2/BP heterostructures that was predicted by theory. Accompanied with the photocarrier interlayer transfer process from WS2 to BP flakes, the change of the absorption of WS2 persists for several nanoseconds. These results promote the consciousness about the carrier dynamics of interlayer transfer process in van der Waals heterostructures and its application in optoelectronic devices.
Categories, diversity, and relevance of memory strategies reported by community-dwelling seniors

ABSTRACT Background: Memory strategies help seniors remember information that is essential for the performance of their daily activities and contribute to their independence in the context of declining memory skills. This study aimed to analyze the categories, the diversity, and relevance of memory strategies known by seniors, and to identify individual characteristics that correlated with these variables. Methods: The sample consisted of 294 participants aged 60 and over who decided to take part in a cognitive vitality promotion program. An adapted version of the memory situation questionnaire (Troyer, 2001) was administered to identify the memory strategies that seniors would use in five daily life situations. A scoring grid, also adapted from the questionnaire's original version (Troyer, 2001), was used to quantify the relevance of the strategies that were reported by participants. Results: All participants mentioned at least once that they would use a strategy from the physical category of memory strategies. Out of a possible range of 26 strategies, participants answered an average of 6.14 (SD = 1.7) different answers across the five situations. Based on expert consensus, 67.7% of the mentioned memory strategies were relevant. Diversity and relevance were significantly higher when trying to remember appointments, things to bring or phone numbers (p ≤ 0.05). The level of education, cognitive skills, and participation in leisure activities were related to diversity and relevance of reported strategies. Conclusions: Seniors know various and relevant memory strategies to perform daily activities. The advantages of integrating strategies that they already know in cognitive health promotion programs should be considered in further studies.
Allelic loss on chromosomes 8p, 22q and 18q (DCC) in human prostate cancer

Previous studies have suggested the involvement of tumour‐suppressor genes on chromosomes 8p, 22q and 18q (DCC) in prostate cancer. The aim of this study was to further characterize these regions. We investigated 20 polymorphic regions on the 3 chromosome arms in 43 cancers and 10 cases of benign prostatic hyperplasia (BPH). Allelic loss was observed in 72% of cancers on 8p, 16% on 22q and 24% at DCC. For BPH, loss was observed in 20% on 8p and in 12% at DCC. The low incidence of LOH on 22q implies that this locus has no significant role in prostate carcinogenesis. At DCC, although the overall incidence was low, tumours with LOH were mostly of high grade or had metastases, suggesting a role for this gene in prostate cancer progression. On chromosome 8p, 29% of cancers had deletions at the LPL locus on 8p22 and 60% had deletions within a region flanked by the markers D8S339 and ANKI on 8p11.1‐p21.1. Within this region, 2 distinct areas of allelic loss were observed, at one or both ANKI and D8S255, and in the region defined by the markers D8S259‐D8S505. For the regions 8p22 and ANKI‐D8S255, tumours with metastases had a greater frequency of LOH compared to non‐metastasizing tumours, suggesting the presence of putative metastasis‐suppressor genes in these regions. © 1996 Wiley‐Liss, Inc.
Konjunkturanalyse mit einem Gleichgewichtsmodell für die deutsche Wirtschaft

Es wird kontrovers daruber diskutiert, ob die Rezession in Deutschland im Jahr 2009 von einem Einbruch des Welthandels oder von einem Angebotsschock aufgrund der Probleme im Bankensektor verursacht wurde. Gemas dem neuen DSGE-Modell des Instituts der deutschen Wirtschaft Koln haben sowohl die rucklaufige Auslandsnachfrage als auch ein Produktivitatsruckgang den Wirtschaftseinbruch in Deutschland ausgelost. Der Produktivitatsschock kann allerdings auch auf unausgelastete Kapazitaten und die rucklaufige Investitionstatigkeit zuruckgefuhrt werden. Er spiegelt somit ebenfalls einen Nachfrageschock wider. Die DSGE-Modelle konnen dies aufgrund ihrer Konstruktion nicht adaquat abbilden.
Functional definition and characterization of acute traumatic coagulopathy

Objective:To identify an appropriate diagnostic tool for the early diagnosis of acute traumatic coagulopathy and validate this modality through prediction of transfusion requirements in trauma hemorrhage. Design:Prospective observational cohort study. Setting:Level 1 trauma center. Patients:Adult trauma patients who met the local criteria for full trauma team activation. Exclusion criteria included emergency department arrival >2 hrs after injury, >2000 mL of intravenous fluid before emergency department arrival, or transfer from another hospital. Interventions:None. Measurements:Blood was collected on arrival in the emergency department and analyzed with laboratory prothrombin time, point-of-care prothrombin time, and rotational thromboelastometry. Prothrombin time ratio was calculated and acute traumatic coagulopathy defined as laboratory prothrombin time ratio >1.2. Transfusion requirements were recorded for the first 12 hrs following admission. Main Results:Three hundred patients were included in the study. Laboratory prothrombin time results were available at a median of 78 (62–103) mins. Point-of-care prothrombin time ratio had reduced agreement with laboratory prothrombin time ratio in patients with acute traumatic coagulopathy, with 29% false-negative results. In acute traumatic coagulopathy, the rotational thromboelastometry clot amplitude at 5 mins was diminished by 42%, and this persisted throughout clot maturation. Rotational thromboelastometry clotting time was not significantly prolonged. Clot amplitude at a 5-min threshold of ≤35 mm had a detection rate of 77% for acute traumatic coagulopathy with a false-positive rate of 13%. Patients with clot amplitude at 5 mins ≤35 mm were more likely to receive red cell (46% vs. 17%, p < .001) and plasma (37% vs. 11%, p < .001) transfusions. The clot amplitude at 5 mins could identify patients who would require massive transfusion (detection rate of 71%, vs. 43% for prothrombin time ratio >1.2, p < .001). Conclusions:In trauma hemorrhage, prothrombin time ratio is not rapidly available from the laboratory and point-of-care devices can be inaccurate. Acute traumatic coagulopathy is functionally characterized by a reduction in clot strength. With a threshold of clot amplitude at 5 mins of ≤35 mm, rotational thromboelastometry can identify acute traumatic coagulopathy at 5 mins and predict the need for massive transfusion.
Factor Structure and Psychometric Properties of the Posttraumatic Stress Disorder (PTSD) Checklist and DSM-5 PTSD Symptom Set in a Long-Term Postearthquake Cohort in Armenia

Psychometric properties of the Armenian-language posttraumatic stress disorder (PTSD) Checklist–Civilian version (PCL-C) and the DSM-5 PTSD symptom set were examined in a long-term cohort of earthquake survivors. In 2012, 725 survivors completed the instruments. Item-/scale-level analysis and confirmatory factor analysis (CFA) were performed for both scales. In addition, exploratory factor analysis (EFA) was conducted for DSM-5 symptoms. Also, the differential internal versus external specificity of PTSD symptom clusters taken from the most supported PTSD structural models was examined. Both scales had Cronbach’s alpha greater than . 9. CFA of PCL-C structure demonstrated an excellent fit by a four-factor (reexperiencing, avoidance, numbing, and hyperarousal) model known as numbing model; however, a superior fit was achieved by a five-factor model (Elhai et al.). EFA yielded a five-factor structure for DSM-5 symptoms with the aforementioned four domains plus a negative state domain. This model achieved an acceptable fit during CFA, whereas the DSM-5 criteria-based model did not. The Armenian-language PCL-C was recommended as a valid PTSD screening tool. The study findings provided support to the proposed new classification of common mental disorders, where PTSD, depression, and generalized anxiety are grouped together as a subclass of distress disorders. Recommendations were made to further improve the PTSD diagnostic criteria.
Induction of glucose‐regulated proteins in Xenopus laevis A6 Cells

We have characterized the induction of glucose‐regulated proteins (GRPs) in Xenopus laevis A6 cells, a kidney epithelial cell line. Exposure of A6 cells to medium in which 2‐deoxyglucose replaced galactose resulted in enhanced synthesis of two proteins at 78 and 98 kd. The 78 kd protein was determined by two‐dimensional PAGE to consist of two isoelectric variants with pls of 5.3 and 5.2 whereas the 98 kd protein resolved into a single spot with a pl of 5.1. The 78 kd protein cross‐reacted with antiserum against chicken GRP78 (glucose‐regulated protein), suggesting that the Xenopus protein shares homology with a previously characterized GRP. This was supported by the finding that a rat GRP78 probe hybridized with a 2‐deoxyglucose‐inducible mRNA. Synthesis of the two proteins was also induced by tunicamycin, 2‐deoxygalactose, and dithiothreitol. However, the GRPs were not induced by glucosamine or calcium ionophore A23187 at concentrations and exposure periods that have previously been shown to elicit a GRP response in mammalian and avian cells. Enhanced synthesis of the two GRPs by 2‐deoxyglucose was transient, reaching maximal levels by 12‐24 h and decreasing to near control levels by 48 h. Removal of the stress at the point of peak synthesis resulted in decreased synthesis of both proteins within 6 h and a return to control levels within 24 h of recovery. These data suggest that Xenopus cells have a GRP response that is similar, but not identical, to that found in mammalian cells.
Tibolone, a Steroid with a Tissue‐Specific Hormonal Profile, Completely Prevents Ovariectomy‐Induced Bone Loss in Sexually Mature Rats

Tibolone (Org OD 14) is a synthetic steroid with combined estrogenic, progestagenic, and androgenic properties and behaves as a tissue‐specific steroid. In the current study, we determined the effects of a 4‐week treatment with different doses of tibolone on estrogen deficiency–induced bone loss in mature 3‐month‐old rats. As a reference, 17α‐ethinyl estradiol (EE2) was used. The frequency of administration, once or twice a day, was also studied. Bone parameters were determined in sham operated controls, ovariectomized (OVX) controls and OVX‐treated rats. Bone loss was assessed by peripheral quantitative computed tomography directly and by quantitative Roentgen densitometry after defatting to exclude influence of fat changes. Femoral bone geometric parameters, plasma osteocalcin level, and urinary deoxypyridinoline/creatinine ratio were also determined. Ovariectomy caused a significant decrease in trabecular bone mineral density in the distal metaphyseal part of the femur using both methods, whereas no change in cortical bone density was found. Trabecular bone loss was prevented in a dose‐dependent manner by tibolone (250, 1000, and 4000 μg/rat/day) when given once or twice daily. EE2 also prevented trabecular bone loss but its efficacy was dependent upon the frequency of dosing. Both tibolone and EE2 induced a significant reduction in the urinary deoxypyridinoline/creatinine ratio and plasma osteocalcin level. Tibolone and EE2 had no effect on other femoral bone parameters except a reduction in femoral length. In conclusion, treatment with tibolone for 4 weeks prevented OVX‐induced bone loss by suppressing both bone resorption and bone turnover in a similar way as EE2. However, the frequency of dosing is more important for EE2 than for tibolone. Tibolone acts in this animal model for postmenopausal bone loss as an estrogen agonist on bone.
Recomendaciones para el diagnóstico y manejo de la anemia por déficit de hierro en la mujer embarazada

La anemia es una condicion altamente prevalente a nivel mundial y, el deficit de hierro, la causa mas frecuente, sin excepcion; la mujer embarazada esta particularmente en riesgo dada la mayor demanda de hierro que la gestacion significa. La anemia se asocia a mayor morbilidad y mortalidad materno-perinatal. En mujeres embarazadas sin anemia, la prevencion, mediante el uso de multivitaminicos que contienen hierro en dosis de 30-60 mg de hierro elemental, ha demostrado ser efectiva y se recomienda durante todo el embarazo. En casos de anemia, el diagnostico de deficit de hierro se establece cuando la ferritina es menor a 30 ug/L y/o la saturacion de transferrina es menor a 20%. La severidad de la anemia y la situacion temporal en el embarazo, son factores modificantes del tratamiento. En mujeres embarazadas, con hemoglobina ≥9.0 g/dL y que tengan <34 semanas de embarazo, la indicacion es tratamiento con hierro oral, en dosis de 100 mg al dia, en dias alternos, hasta normalizar los parametros antes mencionados. Si la hemoglobina es <9.0 g/dL, o el embarazo es ≥34 semanas, el uso de hierro intravenoso ha demostrado ser mas efectivo en corregir la anemia y el deficit de hierro y en disminuir la morbilidad materno-perinatal. En estos casos, sugerimos el uso del hierro carboximaltosa, dado su perfil de seguridad y efectividad favorable. Recomendamos conocer y practicar estas recomendaciones para el diagnostico y manejo de la anemia por deficit de hierro durante el embarazo.
The Importance of a Comprehensive , Patient-Centered Approach to End-of-Life Care

Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles, CA, USA; Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA, USA; Department of Health Policy & Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Harry J. Duffey Family Pain and Palliative Care Program, Johns Hopkins Kimmel Cancer Center, Baltimore, MD, USA.
Cortico-striate interrelations in the albino rat.

Interest in connexions between the cerebral cortex and corpus striatum has been revived by the work of Dusser de Barenne, Garol & McCulloch (1942) using the strychnine method. Although this work is now largely disregarded there has persisted the widespread concept that the cortical afferents to the striatum are derived from areas 4 and 6 (Jung & Hassler, 1960, pp. 869-70). In fact the contention of Dusser de Barenne and his colleagues that there is a differential projection to the caudate nucleus (from the strip areas) and the putamen (from areas 4 and 6) has never been critically investigated. Examination of the literature further emphasizes the confusion concerning the cortical areas involved and even the postulation that a connexion exists at all. Also the 'fibres of passage' explanation of degeneration seen in the striatum after cortical ablation, used by Wilson (1914) and others, has not been convincingly refuted. Retrograde cell changes in the striatum after cortical ablation have rarely been found (Morrison, 1929). However, Minkowski (1923) reported obvious cell changes after cortical ablation and since that time there have appeared numerous physiological reports recording striato-cortical impulses (Hovde & Mettler, 1953; Purpura, Housepian & Grundfest, 1958). In view of these discrepancies it has been decided to reinvestigate Ithe problems of cortico-striate and striato-cortical connexions.
From NETTER to PETTER: PSMA-Targeted Radioligand Therapy

In this month’s issue of The Journal of Nuclear Medicine, Rahbar et al. present exciting retrospective German multicenter data (12 centers) on the performance of prostate-specific membrane antigen (PSMA)–targeted radioligand therapy (RLT) using 177Lu-PSMA 617 in metastatic castration-resistant prostate cancer (mCRPC) (1). The authors describe in detail the safety and efficacy of this new theranostic approach applied under the compassionate use provision in 145 patients. It took 20 y for somatostatin receptor–directed RLT (also commonly abbreviated as PRRT for peptide receptor RLT) to get close to European Medicines Agency as well as Food and Drug Administration approval (as of today still pending). However, PSMA-directed therapy seems to be off to a promising start. The high demand for PSMA-directed RLT started with the initial report by Zechmann et al. who described the use of a 131I-labeled PSMA ligand (2). After
The psychosocial work environment and musculoskeletal disorders: design of a comprehensive interviewer-administered questionnaire.

BACKGROUND Psychosocial working conditions are likely to contribute to work-related musculoskeletal disorders (WRMSDs), but a lack of standardized measurement tools reflects both the theoretical and methodological limitations of current research. METHODS An interdisciplinary team including biomedical, behavioral, and social science researchers used an iterative process to adapt existing instruments for an interviewer-administered questionnaire assessing psychosocial workplace exposure related to musculoskeletal disorders. RESULTS The resulting questionnaire included measures of psychosocial workplace factors based on two theoretical models (the demand-control-support and the effort-reward imbalance models), supplemented by the additional constructs of "emotional demands," and "experiences of discrimination. " Other psychosocial and physical measures selected for questionnaire inclusion address physical workload, sociodemographic and anthropometric characteristics, social relations and life events, health behaviors, and physical and psychological health. CONCLUSION Using an interdisciplinary approach facilitated the development of a comprehensive questionnaire inclusive of key measures of psychosocial factors that may play a role in the complex mechanisms leading to WRMSDs.