Miracle-dz/UniFAR-FTUs huggingface dataset:
Trunk or branch? Identifying and targeting intratumoral heterogeneity in hepatocellular carcinoma using genomics and patient derived primary cancer cells

Precision oncology aims to deliver personalized treatment to individual patients based on genomic profiling of tumors (1). Molecular targeted therapies have been developed based on the identification of “oncogene drivers” from large-scale genomic studies; leading to several successful genotype-directed clinical applications of targeted therapies (2,3). However, complete and durable responses to these therapies are rare, and the residual tumors eventually acquired new mutations or rewired signaling pathways to by-pass blockade of these targeted therapies (4-6). Moreover, intratumoral heterogeneity (ITH) and tumor evolution play key roles in resistance mechanisms in targeted therapies (7). Therefore, current research efforts have been focusing on identifying these molecular changes in resistant tumors in search for more effective rational combination treatment to overcome resistance mechanisms.
Viral Marketing Strategies in Palestine Cellular Communications Company (Jawwal)

This study aimed to identify the viral marketing strategies in Palestine Cellular Communications Company (Jawwal), where the researchers used the descriptive analytical method, through a questionnaire randomly distributed to the sample of workers in Palestine Cellular Communications Company (Jawwal) In the Gaza Strip reached (60) employees. The results of the study showed that there is a high level of viral marketing in Palestine Cellular Communications Company (Jawwal), where the total score was relative (82.17%). The order of dimensions of viral marketing was as follows: material stimulation and free offers with a relative weight (86.81%), opinion leaders "influential spoken word with a relative weight (83.76%), viral advertising campaigns with a relative weight (81.17%), electronic publishing media with a relative weight ( The results showed that there are differences due to the gender variable in Palestine Cellular Communications Company (Jawwal) in favor of males, and there are no differences due to the age variable, and there are differences due to the variable years of service in the field of electronic publishing and the total degree of viral marketing. The study made a number of recommendations, including: Increasing interest in using social media as an important area for viral marketing campaigns. Attention to the use of electronic publishing means to motivate beneficiaries to receive the company's services. Increase the trust of beneficiaries in the company's services by offering competitive campaigns that meet the needs of the beneficiaries. Mainstreaming viral marketing to different Palestinian companies as a modern marketing approach that leads to quick results.
Visualized Information Graphic Design of Intangible Culture Heritage

: In order to construct a convenient, interesting information graphic design and user interaction system, based on Visualized enhanced display technology, a life application system is development. The system integrates Visualized interactive service module, mobile user terminal module, Web communication service module, and information recording module. The user turns on the mobile user terminal and obtains functional services such as Visualized interactive mode and navigation area introduction. The service information is enter into the information-recording module, and the user selects and records the information via the Web to exchange and share. Experiments display that the application system is convenient and interesting. The results display that the application of the proposed system can satisfy the daily needs of cultural heritage.
Book Tax Differences, Operating Cash Flow, Leverage and Earning Persistence in Indonesia Manufacturing Companies

Current earnings can be used by investors to predict future earnings if the earnings are of high quality (persistent). This study examines the effect of book tax differences, operating cash flow and debt level on earnings persistence. This study uses manufacturing companies listed on the Indonesia Stock Exchange (IDX) in 2014-2016 as populations. Based on data analysis with ordinary least square regression, the results show that two hypotheses are accepted, namely temporary book tax differences and cash flow from operating. As hypothesized, book tax differences negatively affect earnings persistence and operating cash flow has a positive effect on earnings persistence. Meanwhile, permanent book tax differences have not been proven to influence earnings persistence.
‘Nutrimune®’ and immune defence against pathogens in the gastrointestinal and upper respiratory tracts: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006

Abstract Following an application from H.J. Heinz Supply Chain Europe B.V. , submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of the Netherlands, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to ‘Nutrimune®’ and immune defence against pathogens in the gastrointestinal (GI) tract and upper respiratory tract (URT). The food ‘Nutrimune®’ (a pasteurised cow's skim milk fermented with Lactobacillus paracasei CBA L74) which is the subject of the health claim is sufficiently characterised. The Panel considers that immune defence against pathogens in GI tract and URT is a beneficial physiological effect. One human intervention study from which conclusions can be drawn showed an effect of ‘Nutrimune®’ on immune defence against pathogens in the GI tract and the URT, and the results from one animal study could support an effect of ‘Nutrimune®’ on defence against pathogens in the GI tract. However, there were inconsistencies in the reporting of the process and criteria used for the diagnosis of URTI in the human intervention study, the results of this study have not been replicated, and no evidence was provided for a plausible mechanism by which ‘Nutrimune®’ could exert the claimed effect in vivo in humans. The Panel concludes that the evidence provided is insufficient to establish a cause and effect relationship between the consumption of ‘Nutrimune®’ and immune defence against pathogens in the gastrointestinal and upper respiratory tracts.
Social network, social support and unplanned hospital admission in older patients with cancer.

201Background: Cancer incidence is rising as the number of older adults increases. Lack of social support has been found to predict mortality among cancer patients. Emotional support has been reported to be the most desirable type of social support. Methods: The data was collected prospectively, and analysis conducted in a retrospective manner, in a cohort of older adults seen at the Program for Healthy Aging at the MD Anderson Cancer Center between Jan 2013 and December 2015. Demographics, cancer diagnosis, and other geriatric conditions were diagnosed and collected during comprehensive geriatric assessments. Social supports were measured through self-report RAND’s Medical Outcomes study (MOS) questionnaires. Overall social support and sub domains (emotional, informational, tangible, affectionate, and positive interaction) were scored. Outcomes including unplanned hospital admission were collected through reviewing of medical records. Pearson chi-square or the Fisher exact tests were used to compare grou.
Identifying Sea Ice Ridging in SAR Imagery using various Machine Learning Models

Sea ice ridging presents a great challenge to ships navigating thearctic. In this paper, we examine the capabilities of various machinelearning methods in predicting regions of high ridge density fromSAR imagery of Hudson Strait. Our results showed that althoughridging in Hudson Strait may be difficult to distinguish even with thehuman eye, machine learning can give some insight into potentiallydangerous regions of Hudson Strait.
Privacy Concerns in the VR and AR Applications in Creative Cultural Industries

Creative culture industry refers to industries that combine the creation, distribution, production, and commercialization of creative contents in advertising, design, film & video, interactive leisure software, music, publishing, and television and radio. This chapter focuses on the museum sub-sector of the creative cultural industries. These sub-sectors have eagerly embraced digital technologies to promote cultural heritage by transforming their archaeological finds into more immersive creative and cultural contents. However, the pervasive nature of mobile technologies and the heavy reliance on consumers' locational information have caused rising privacy concerns among consumers. This chapter employed a text mining study to explore how potential privacy infringement, as one of the most observable social impacts of mobile-based and location-sensitive AR and VR technologies, is discussed in major media outlets around the world. Discussions and implications conclude the chapter.
2 Diagnosis and Neuroprotection in Parkinson's Disease

Insidious onset of mild, unspecific vegetative, psychopathological, cognitive and perceptive disturbances with a resulting change of personal behavior often precede the initially intermittend occurring motor symptoms in patients with Parkinson’s disease (PD). Thus the current available diagnostic tools and concepts do not enable such an early diagnosis of Parkinson’s disease. However they are necessary to perform an effective neuroprotective treatment regimes, since neuronal dopaminergic death is advanced at the clinical treshold of onset of motor symptoms. Treatment of these symptoms should be formed in a more continuous fashion, in order to imitate and provide more physiological conditions of dopaminergic neurotransmission. This delays onset of motor complications, which may be interpreted as a certain neuroprotective effect from the clinical point of view. List of Abbreviations: 5‐HT, 5‐hydroxytryptamine; PD, Parkinson’s disease
The Influence of DMBA (7,12-dimethylbenz-(a)anthracene) Regimen In The Development of Mammae Carcinogénesis on Sprague Dawley Female Rat

There are many methods for development of mammae cancer animal model, one of which is chemical induction using carcinogenic agent, DMBA. This research aimed to explore the influence of dose and time regimens of DMBA on development of mammae carcinogenesis on Sprague dawley female rats. The first study was 50 rats treated with 20 mg/kg bw of DMBA orally for eleven times at twice a week. Morphological evaluations were conducted with mammae palpation for 15 weeks and then all of rats were sacrificed for collecting mammae organs for histological analysis using hematoxylin-eosin staining. The results showed that the first and the latest nodules appeared at the fourth-week and the fourteenth-week after ending DMBA induction, respectively, in which the most often nodule appearances were at the seventh-week. The number of nodule incidence and multiplicity were by 74% and 2 noduls/rat, respectively. Histological analysis of mammae glands determined that they fell under in Ductal Carcinoma Invasive (DCIV) category. The second study was 25 rats gavaged orally with DMBA at dose 20 mg/kg bw for five times every three days. After palpating for 15 weeks, the results showed that no nodule was observed but the histological analysis demonstrated developing of mammae gland carcinogenesis reaching about 60% Ductal Carcinoma Insitu (DCIS) and 40% Ductal Carcinoma Invasive (DCIV) stages. Based on the results of this study can be concluded that the dose and frequency of DMBA will affect the successful development of mammary gland carcinogenesis. In DMBA induction with low frequency, no data showed the incidence and multiplicity of tumor, but histopathologic level carcinogenesis can be distinguished. In DMBA induction with high frequency, incidence and multiplicity of tumor data can be obtained but can not be distinguished histopathologically. Keywords: DMBA, doses, carcinogenesis, mammae, histopatology
How Market Value Relates to Corporate Philanthropy and its Assurance. The Moderating Effect of the Business Sector

Corporate philanthropy strategy integrated into the core business constitutes a novel vision and a little&#8208;explored field of study with regard to corporate social commitment. The goal of this study is to analyse how the diverse ways of managing and assuring philanthropy can be considered signals of a firm's social commitment and consequently affect its market value. In addition, the analysis considers whether the business sector moderates those relationships. We aim to provide a comprehensive vision of corporate philanthropy and its effect on market value. From a sample of 965 firm&#8208;years, of 193 firms from 2011 to 2015, we found that the market responds positively to the professional, independent management of philanthropy via a foundation, in preference to donations, and welcomes external assurance of corporate philanthropy as a set of actions that improve the perceived reliability of philanthropic activities. In addition, we observe a moderating effect of the business sector on the relationships among corporate philanthropy, assurance and the company's market value. The main contribution of this study is the provision of new evidence of how corporate philanthropy and its assurance are effective signals that reduce the information asymmetries between firms and investors, affecting company market value positively.
MRST-Shale: An Open-Source Framework for Generic Numerical Modeling of Unconventional Shale and Tight Gas Reservoirs

 OpenShale successfully applied in field history matching and new model evaluation 11 12 Abstract 13 We present a generic and open-source framework for the numerical modeling of the expected 14 transport and storage mechanisms in unconventional gas reservoirs. These unconventional reservoirs 15 typically contain natural fractures at multiple scales. Considering the importance of these fractures in 16 shale gas production, we perform a rigorous study on the accuracy of different fracture models. The 17 framework is validated against an industrial simulator and is used to perform a history-matching 18 study on the Barnett shale. This work presents an open-source code that leverages cutting-edge 19 numerical modeling capabilities like automatic differentiation, stochastic fracture modeling, 20 multi-continuum modeling and other explicit and discrete fracture models. We modified the 21 conventional mass balance equation to account for the physical mechanisms that are unique to 22 organic-rich source rocks. Some of these include the use of an adsorption isotherm, a dynamic 23 permeability-correction function, and an embedded discrete fracture model (EDFM) with 24 fracture-well connectivity. We explore the accuracy of the EDFM for modeling 25 hydraulically-fractured shale-gas wells, which could be connected to natural fractures of finite or 26 infinite conductivity, and could deform during production. Simulation results indicates that although 27 the EDFM provides a computationally efficient model for describing flow in natural and hydraulic 28 fractures, it could be inaccurate under these three conditions: 1. when the fracture conductivity is 29 very low. 2. when the fractures are not orthogonal to the underlying Cartesian grid blocks, and 3. 30 when sharp pressure drops occur in large grid blocks with insufficient mesh refinement. Each of 31 these results are very significant considering that most of the fluids in these ultra-low matrix 32 permeability reservoirs get produced through the interconnected natural fractures, which are 33 expected to have very low fracture conductivities. We also expect sharp pressure drops near the 34 fractures in these shale gas reservoirs, and it is very unrealistic to expect the hydraulic fractures or 35 complex fracture networks to be orthogonal to any structured grid. In conclusion, this paper presents 36 Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 9 January 2020 doi:10.20944/preprints202001.0080. v1
A EMERGÊNCIA DO GÊNERO “RESUMO EXPANDIDO” SOB A ÓTICA DA TEORIA DA COMPLEXIDADE

Esta pesquisa objetiva relacionar alguns pressupostos da Teoria da Complexidade (LARSEN-FREEMAN, 2008; MORIN, 2011) com a nocao de generos textuais – na perspectiva dialogica da linguagem de Bakhtin –, identificando, por meio dos elementos constitutivos dos generos – conteudo, estilo e construcao composicional –, em que condicoes o genero textual secundario “resumo expandido” emerge na esfera academica. Para tanto, realizamos uma breve discussao sobre os Generos Textuais e a Teoria da Complexidade, abordando algumas questoes substanciais para a compreensao dessas duas abordagens teoricas como convergentes a partir da discussao dos seguintes topicos: os generos na visao bakhtiniana; o genero textual secundario “resumo expandido”; a emergencia sob a otica da complexidade; e a emergencia do genero “resumo expandido”. Nesse sentido, entendemos que sao as condicoes de uso e a necessidade de mudanca que abrem espaco para que um genero possa emergir, de modo que ao analisarmos o genero “resumo expandido” sob a otica do pensamento complexo, tanto a abertura como a plasticidade dos generos se tornam evidentes. Assim, percebemos que o tripe constituido por conteudo, estilo e construcao composicional evidencia a natureza multidimensional e complexa dos generos textuais, por meio da relacao existente entre esses elementos e a esfera da comunicacao na qual os generos se ancoram.
Pengenalan Aksara Jawa dengan Menggunakan Algoritma Convolutional Neural Network

Abstrak Aksara jawa merupakan salah satu warisan budaya suku Jawa yang penggunaannya perlu dilestarikan. Aksara jawa memiliki bentuk tulisan yang unik dan memiliki makna yang berbeda menyebabkan perlunya pembelajaran atau merupakan warga asli yang sering membaca tulisan tersebut. Dengan teknologi yang telah berkembang sampai saat ini, dapat dimanfaatkan untuk meningkatkan kesadaran dan kemudahan dalam mempelajari budaya jawa tersebut. Pada penelitian ini dibuat sebuah sistem yang mampu mengenali gambar aksara jawa yang ditulis tangan pada lembaran kertas. Algoritma Convolutional Neural Network (CNN) digunakan sebagai basis pembuatan sistem, dimana CNN dapat mengenali tulisan tanpa menggunakan algoritma ekstrasi fitur tambahan. Dalam penelitian ini CNN mampu mengenali gambar tulisan dengan performansi model 95,35% pada saat proses pelatihan menggunakan data training. Hasil klasifikasi pada data test menghasilkan akurasi sebesar 73%, menunjukkan bahwa CNN dapat mengenali sebagian besar gambar tulisan tangan aksara jawa. Kata kunci: Convolutional Neural Network, pengenalan tulisan, aksara jawa _______________________________________________________________ Abstract Javanese script is one of many heritages of Javanese tribe, which in need to be preserved. With how unique its style and how each word has different meaning, to understand Javanese script means the need of learning the script or simply is a native that has frequently read the script. Current technology makes it possible to increase awareness and make easier access to learn the culture. This research has built a system which managed to recognize handwritten Javanese script images that were drawn in papers. Convolutional Neural Network algorithm is the basis of the system, which managed to recognize the script without any extra feature extraction method. The performance of model of the CNN is around 95,35%. The classification result of test data yields around 73% which shows how CNN is capable of recognizing most of handwritten Javanese script. Keywords: Convolutional Neural Network, character recognition, Javanese scrip
Understanding Sonography Clinical Decision-Making Learning Through Student Voices

Sonographers assume an important role in providing accurate diagnosis for prompt patient management. The manual task of scanning competency is driven by a high level of cognitive function in the form of clinical decision making (CDM). It is therefore critical that sonography students are grounded in the CDM fundamentals as part of their sonography education. The aim of this article is to seek better understanding of student views on CDM learning to inform educators of strategies to better support student learning. The first part of the article describes how CDM for sonography students is being developed at The University of Auckland. The second part of the article explores student perspectives of CDM learning and the application of CDM in the workplace. Using purposive sampling, five clinical supervisors and two students participated in semistructured interviews. Focus groups with students were conducted at the end of each semester, between July 2014 and June 2016. Thematic analysis was used to analyze and make sense of the data. Based on these qualitative findings, the authors make recommendations to advance CDM within the sonography curriculum.
Axillary lymph node status, age at presentation and menopausal status in female breast cancer patients attending a government tertiary care teaching hospital in Mysore, Karnataka, India

Background: Breast cancer is now the leading cause of cancer among Indian women. This study was aimed at creating a database of female breast cancer patients with emphasis on age, menopausal and axillary lymph node metastasis. Methods: A retrospective study was conducted among 103 female breast carcinoma patients who sought treatment in the Department of General Surgery from 2016 January to December. Various data including age at presentation, menopausal status, lymph node status, grade of the tumor, family history of breast cancer, location, size of the tumor and histopathological types were studied. Results: Mean age of the study population was 52.7years. Of the 103 patients, 70.9% were post-menopausal. Among different clinical and pathological variables, Grade of the tumor and menopausal status were showing statistically significant association with positive axillary lymph nodal status. Conclusions: The variables which are predictive of axillary lymph node involvement in breast cancer are tumour grade and menopausal status. The current data may be used to tailor the management protocol of patients with breast carcinoma in this region of the country.