Miracle-dz/UniFAR-FTUs huggingface dataset:
A role for lnc-DILC in liver cancer stem cells

As the sixth most common malignant tumor, the mortality rate of hepatocellular carcinoma (HCC) is the second highest worldwide (1). Despite the great amount of progress regarding the diagnosis and treatment for HCC in recent years, the long-term survival of HCC patients remains unsatisfactory. Dismal prognosis and frequent recurrence of HCC has limited patients’ survival (2). Therefore, new targets for HCC diagnosis and treatment and the strategy for research on HCC are required to be adjusted efficiently. Liver cancer stem cells (LCSCs) have the ability of selfrenewal and multi-directional differentiation, which are considered to be the origin of HCC initiation, propagation, metastasis, relapse and chemo-resistance (3). However, the regulatory mechanism of LCSCs is still unclear. It is constructive to study the molecular mechanism of LCSCs in the pathogenesis of HCC progression. At the same time, finding new therapeutic targets regarding LCSCs is also significant. Recent studies found that long noncoding RNAs (lncRNAs), present widely in eukaryotes, are involved in the regulation of diverse physiological and pathological processes in various cancers. Some evidence has indicated that lncRNAs participate in the regulation of the occurrence and development of HCC (4), and play a role in the maintenance and differentiation of the HCC cells (5). However, there are still lots of gaps between the function and mechanism of lncRNAs in LCSCs.
Expecting The Unexpected: Climate Resilience In Malaysian Local Government Land Use Planning

A resilient city will strive from stress driven by climate change and play pivotal role in climate adaptation initiatives. Thus, it is imperative that the Local Government of cities as the urban managers and city planners to effectively mainstream climate resilience adaptation in the planning processes of the local government. The aim of this research is to understand and explore the challenges faced by the Malaysian Local Government, particularly Land Use Planning (LUP) in Penang adapting to climate change. Secondly, it is to identify key defining changes needed in LUP to facilitate climate resilience adaptation. A multi method approach was used to gather data: four sessions of focus group discussion were carried out encompassing officers from the planning department of the local government, state and federal government officers, representatives from the property developers’ association, civil societies and representatives from a local university. Two sessions of interviews were also conducted with policy makers. Results implore four imperative challenges that post bigger opportunities for change including leadership on sustainable development, reliability and collation of spatial and non-spatial data, the need for transdisciplinary planning team and a climate proof land use planning approach. The findings are a steppingstone in determining the priority of LUP for the next few decades but also the physical parameter of growth of Penang. © 2019 Published by Future Academy www.FutureAcademy. org.UK
Design of Prosthetic Components for Skiing: A Preliminary Study

ABSTRACT Introduction: Prostheses are fundamental for daily living and to allow participation in sport. However, current components may not optimize the skiers' center of mass (COM), resulting in poor control and balance. This may explain why transfemoral prosthesis users often choose to ski without prostheses. Materials and Methods: Existing literature on skiing biomechanics, skiing with limb loss, and the available prosthetic componentry for skiing was examined. Normal biomechanics were ascertained for comparison with an able-bodied skier and 2 two-track skiers using transfemoral prostheses. Laser posture (LP), body segment parameters (BSPs), and pressure-sensitive insoles (PSIs) were compared to determine an appropriate method for calculating the COM in skiers while on the slopes. One able-bodied skier and two skiers with transfemoral amputation were filmed skiing through a set course. The participants wore markers to aid in joint location and help determine the skier's rotation. The footage was analyzed using video analysis software (Siliconcoach) to compare joint angles. The COM for each participant was compared by calculating BSPs. Results: The results indicated that available prosthetic knee joints do not achieve comparable biomechanics to able-bodied skiers. Conclusions: Current prosthetic knees designed to resist flexion for high activity resulted in two-track skiers having difficulty when flexing the knee during the inside of the turn. In addition, it was found that increasing the knee flexion resulted in posterior translation of the COM, which can lead to poor ski control.
Sibling rivalry disorder: Issues of diagnosis and management- A case report

The birth of a sibling is a major source of stress in the life of a child. Child’s emotional and behavioural reaction to this event and effort to cope with ambivalent feeling depends on his/her interactions with parents before, and after the birth of a second child. This case report aims to highlight the importance of exploring and also considering family environment and interaction patterns among family members, in conceptualizing the problem and planning intervention in the case of a 5-year-old female child referred to neuropsychology OPD of IHBAS having an initial impression of generalized epilepsy with hallucinations. Clinical interview with parents and grandmother along with psychological assessment shed light that the child and parents had problem adjusting with the arrival of her baby sister and difficulty in adjusting with new roles of her parents, facilitating to conceive the case as Sibling rivalry disorder. The case report also highlights the use of not so commonly used intervention, i.e. Parent-child interaction therapy, with play therapy and parents’ counseling. Intervention with the child was focused to achieve conflict resolution, emotional regulation including improving the quality of interaction with parents and grandmother. Child was followed up for 6 months. Effective parenting skills especially parent child interaction is an important factor in a child’s mental health.
Community interventions in Zimbabwe: analysis of a multi-site replication.

With 600000-1000000 inhabitants Bulawayo is Zimbabwes second largest city. It is an industrial transport and military hub with a high rate of sexually transmitted disease. An HIV intervention was implemented under the direction of the Bulawayo City Health Department. The intervention model chosen sought to integrate community mobilization AIDS education condom promotion and STD control through training peer education community outreach condom distribution improved STD services drama/music support for people with HIV/AIDS and income generation. Although the program began by targeting vulnerable groups it was soon expanded into a community-level program combining targeted intervention with community-wide outreach and mobilization. The authors describe program activities coverage and impact. The program has since been replicated in five other sites in Zimbabwe. The authors discuss the replication process and lessons learned.
Examining the Mortality of an Unsheltered Homeless Cohort From Boston, MA, 2000 Through 2009

Purpose : This dissertation addressed a gap in homelessness literature by examining mortality outcomes of an unsheltered cohort and by applying criteria developed at the Boston Health Care for the Homeless Program (BHCHP) to predict mortality. Methods: A 10-year prospective study was conducted with 445 unique unsheltered individuals. Data were collected during encounters with BHCHP’s Street Team clinicians, an integrated program providing care to homeless adults living outside. Decedent data were matched to the Massachusetts Department of Public Health death occurrence files. Analyses included describing the cohort and the high-risk criteria, calculating age-standardized all-cause and cause-specific mortality rates and age-stratified rate ratios using two comparison groups: the Massachusetts population and a general homeless cohort, and conducting survival analysis. The same methods were used when the high-risk for mortality was applied and the cohort was divided into a high-risk group and non-high-risk group. Results: During the study, 134 deaths occurred. The average age of death was 53 years old. The cohort was largely white and men. Blacks had a lower rate of death compared to whites. The all-cause mortality rate that was almost 10 times higher than the Massachusetts population and nearly three times higher than the general homeless cohort. The most common causes of death were noncommunicable diseases and causes attributable to substance use. Survival analysis showed low probabilities of survival and high rates of mortality for older age groups, men, and whites. Similar patterns of mortality outcomes were seen when the high-risk for mortality criteria were applied. The high-risk group had higher mortality rates than the non-high-risk group; both groups had higher mortality rates for comparisons to Massachusetts and for most comparisons to the general homeless cohort. Survival analysis showed lower probabilities of survival and higher rate of death for the high-risk group.
Deciphering Cattle Temperament Measures Derived From a Four-Platform Standing Scale Using Genetic Factor Analytic Modeling

The animal’s reaction to human handling (i.e., temperament) is critical for work safety, productivity, and welfare. Subjective phenotyping methods have been traditionally used in beef cattle production. Even so, subjective scales rely on the evaluator’s knowledge and interpretation of temperament, which may require substantial experience. Selection based on such subjective scores may not precisely change temperament preferences in cattle. The objectives of this study were to investigate the underlying genetic interrelationships among temperament measurements using genetic factor analytic modeling and validate a movement-based objective method (four-platform standing scale, FPSS) as a measure of temperament. Relationships among subjective methods of docility score (DS), temperament score (TS), 12 qualitative behavior assessment (QBA) attributes and objective FPSS including the standard deviation of total weight on FPSS over time (SSD) and coefficient of variation of SSD (CVSSD) were investigated using 1,528 calves at weaning age. An exploratory factor analysis (EFA) identified two latent variables account for TS and 12 QBA attributes, termed difficult and easy from their characteristics. Inclusion of DS in EFA was not a good fit because it was evaluated under restraint and other measures were not. A Bayesian confirmatory factor analysis inferred the difficult and easy scores discovered in EFA. This was followed by fitting a pedigree-based Bayesian multi-trait model to characterize the genetic interrelationships among difficult, easy, DS, SSD, and CVSSD. Estimates of heritability ranged from 0.18 to 0.4 with the posterior standard deviation averaging 0.06. The factors of difficult and easy exhibited a large negative genetic correlation of −0.92. Moderate genetic correlation was found between DS and difficult (0.36), easy (−0.31), SSD (0.42), and CVSSD (0.34) as well as FPSS with difficult (CVSSD: 0.35; SSD: 0.42) and easy (CVSSD: −0.35; SSD: −0.4). Correlation coefficients indicate selection could be performed with either and have similar outcomes. We contend that genetic factor analytic modeling provided a new approach to unravel the complexity of animal behaviors and FPSS-like measures could increase the efficiency of genetic selection by providing automatic, objective, and consistent phenotyping measures that could be an alternative of DS, which has been widely used in beef production.
Improving Sustainable Development and National Security through Office Technology and Management Programme in Nigeria

The development of skills, knowledge and competence through functional education which is the main focus of office technology and management cannot be over-emphasized. This study is undertaken to examine how sustainable development and national security can be improved through office technology and management.The survey research design was adopted while the population consists of stakeholders in office technology and management in Ekiti State. A sample size of 100 respondents was used. Two research questions guided the study and two hypotheses were formulated for the study. The research instrument used was the questionnaire and it was validated by experts in the field. The mean and standard deviation was used for the analysis of the data and chi-square was used for the hypotheses formulated.The study revealed that sustainable development and national security could be improved throughoffice technology and management if adequate attention is given to maintenance of standard and funding of the programme. It was therefore recommended that government at various levels and other stakeholders in education should give the needed attention to adequate funding of the programme to achieve better result.
Class I KNOX Gene OSH1 is Indispensable for Axillary Meristem Development in Rice

The formation of shoot branches plays a key role in plant development. Here, we show that ORYZA SATIVA HOMEOBOX1 (OSH1), a member of class I knotted-like homeobox (KNOX) genes, is involved in shoot branching in rice (Oryza sativa). During axillary bud formation, OSH1 began to be expressed in the presumptive region of the axillary meristem, and continued its expression in the established axillary meristem. In the osh1 mutant, axillary meristem formation was impaired, resulting in a failure in tiller formation. Considering a suggested role of OSH1 in the shoot apical meristem, OSH1 is likely to play an important role in maintaining undifferentiated cells during axillary bud formation.
Evaluación de Rasgos Acústicos para el Reconocimiento Automático del Habla en Escenarios Ruidosos usando Kaldi

La presente investigacion evaluara el impacto de los Coeficientes Cepstrales en la Frecuencia Mel (MFCC) y los coeficientes Predictores Perceptuales Lineales (PLP), en la tasa de errores de reconocimiento de palabras (WER) de sistemas dedicados al Reconocimiento Automatico del Habla (RAH). La experimentacion se realizara con senales de voz en idioma espanol, en escenarios con niveles de ruido desconocidos y utilizando la herramienta del estado del arte Kaldi. El articulo concluye aportando evidencias a favor de los MFCC como rasgo acustico mas robusto ante la tarea del RAH en escenarios ruidosos con respecto a los PLP; haciendo notar que ambos rasgos se comportar de manera similar en escenarios poco ruidosos y el impacto de los PLP en la reduccion de los tiempos empleados por los sistemas dedicados al RAH. Palabras claves: Reconocimiento Automatico del Habla, Rasgos Acusticos, Kaldi.
Developing a building information modeling–based performance management system for public–private partnerships

Effective performance management (PM) in public–private partnership (PPP) projects is critical to realizing value for money (VFM). This study aims to provide an in-depth understanding of problems existing in PPP PM and possible avenues for improvement, presenting an experimental system to verify that building information modeling (BIM) and other information communication technologies can improve PPP PM. ,The mixed research method adopted in this study combined empirical research with experimental research. Semistructured interviews were used to ascertain the current situation of PPP PM with the help of Nvivo software. A BIM-based performance management system (BPMS), which combines BIM with Web and Cloud technology, was then constructed to achieve performance monitoring, performance measurement, and performance-based payment. Finally, a case study was introduced to explain the function application of the proposed system. ,The case demonstration verified is found to verify that the developed BIM-based execution framework for PPP PM can effectively guide stakeholders toward achieving mixed PM, promote effective PM, and improve work efficiency with the support of BIM and other information and communication technologies. ,Through the development of a BPMS for PPP projects, the effectiveness and efficiency of PM are improved. Practical PM applications are also provided to different stakeholders, through which the key performance indicators and the behaviors of the government and private-sector partners can be monitored to form a more comprehensive and reasonable PM mechanism and promote the realization of VFM in PPP projects.
Therapeutic and Substance Abuse Biomarkers in the Immediate Postpartum Period

The aim of this thesis was to develop the use of therapeutic and substance abuse biomarkers relevant to the immediate postpartum period, to reduce the risk of adverse outcomes in mothers and their infants. A systematic review was conducted to identify the role of opioid pharmacogenetics in analgesic response among postpartum patients, and in adverse events in these patients and their breastfed infants. Following a thorough search of the literature, studies were screened for their eligibility, data was extracted, and study quality was evaluated. Collectively, the 17 studies included in the review revealed that CYP2D6, OPRM1 A118G, UGT2B7 C802T and ABCB1 G2677AT may contribute to postpartum analgesia or adverse events. A nested cohort study was performed to explore the role of codeine pharmacogenetics in a population of 98 post-cesarean women. Participants were genotyped and instructed to report their pain using the visual analog scale 1 h following each dose of codeine. The OPRM1 A118G and UGT2B7 C802T variants were found to predict codeine consumption in the cohort overall (P < 0.001) and among Caucasians (P = 0.001).
An unusual case of primary cardiac prosthetic valve-Associated lymphoma

Primary cardiac tumors are extremely rare neoplasms with an incidence of less than 0.4%. 1-3 Primary cardiac lymphoma (PCL), the majority of which is non-Hodgkin lymphoma, accounts for around 2% of cardiac tumors and less than 0.5% of extranodal lymphomas.1,4-6 Primary lymphoma involving cardiac valves has been described in few case reports and small case series owing to its rarity.7-10 Most cases of PCL present with manifestations of congestive heart failure or cardiac arrhythmias,11 whereas primary valve-associated lymphoma (PV-AL) is usually diagnosed incidentally during valve repair or replacement. The pathophysiology remains unclear, but a few cases have been associated with Epstein Barr virus (EBV). 7 Cases previously described in the literature carried an overall poor prognosis and to date there is no standardized treatment approach. We provide here an unusual case of primary prosthetic valve-associated cardiac large B-cell lymphoma, which was successfully treated with adjuvant chemotherapy after valve repair and which resulted in an excellent long-term outcome.
Investigating the implementation of asthma guidelines to community pharmacy: greater consideration of implementation is required for translation of clinical guidelines into practice

Kim Watkins 5 Abstract Assimilating healthcare research evidence into clinical practice can be challenging. Clinical guidelines are the tools designed to streamline this process. The increasing clinical role of pharmacists has seen an increase in the development of guidelines specifically for pharmacists. However, development and dissemination of clinical guidelines does not necessarily result in improved practice. Crucial to translating evidence is the process of implementation. Despite the importance of effective implementation of clinical guidelines, the scientific literature is inconclusive regarding ideal strategies. Furthermore, there is a significant gap in the literature related to clinical guideline implementation to the community pharmacy setting. Asthma is a chronic disease associated with significant morbidity and mortality, and patients need the support of health professionals to appropriately self-manage this condition. Australia has unique legislation that provides patients with access to asthma reliever medications from community pharmacists, without the necessity for a prescription or consultation with a doctor. The Guidelines for the provision of a Pharmacist Only medication: short-acting beta agonists (SABA guidelines) were developed in 2010. These guidelines were developed specifically for Australian pharmacists to ensure appropriate use of SABAs and referral of patients with suboptimal asthma management. Research had demonstrated practice deficits in this area. An initial implementation of the SABA guidelines and another resource, the Asthma Action Plan card (AAP card), was undertaken over four months from Nov 2010 to February 2011 in Western Australia. Implementation focused on education about the
Experimental myopia and anamalous eye growth patterns unaffected by optic nerve section in chickens: Evidence for local control of eye growth

We surgically sectioned the orbital segments of the optic nerves of chickens to isolate the retina from the brain. We then examined the effects of this surgery on the responses of the growing eye to lid suture and intravitreal injection of kainic acid, procedures which normally cause eye enlargement in chickens. Both techniques alter visually-driven retinal activity, sutured lids by causing optical degradation of the retinal image, and kainic acid, by eliminating subpopulations of retinal neurons. Sectioning of the optic nerve failed to prevent the eye enlargement induced either by lid suture or by kainic acid in our animals. These results suggest that eye growth is modulated locally, perhaps through vision-dependent release of growth factors from the retina itself.
Grammatical Cohesive Devices in Students’ Explanation Texts(A Study of the Fourth Semester Students of English Department, Universitas Negeri Semarang Academic Year 2018/2019)

Writing is one of the most difficult language skill since there are several things to be considered. In order to produce cohesive text, cohesive devices are needed. This final project deals with an analysis of grammatical cohesion devices in students‘ explanation texts. The objectives of this research were to describe what kind of grammatical cohesion devices used by students and what are the mostly used grammatical cohesive devices in their explanation texts. This study used qualitative-descriptive as the research design. The objects of this study are ten explanation texts written by the fourth semester students. The texts were analyzed by employing Halliday and Hasan‘s theory of cohesion (1976). They are reference (personal, demonstrative and comparative), substitution (nominal, verbal and clausal), ellipsis (nominal, verbal and clausal), conjunction (additive, adversative, causal, temporal and others), and lexical cohesion (reiteration and collocation). The findings show that there are 289 grammatical cohesive devices found in students‘ explanation text. Reference 215 (74.4%) is the mostly used grammatical cohesive devices then followed by conjunction 63 (21.8%), substitution 7 (2.4%), and ellipsis 4 (1.4%). There are three cohesive devices that do not exist in students‘ explanation text, those are verbal substitution, clausal substitution, and clausal ellipsis. In addition, even though there are 3 cases of improper use of grammatical cohesive devices such as the use of it, their, and that. In general the text written by students are cohesively produced. The result of the study shows that the students are aware of using grammatical cohesion in their text and it gives benefits to the cohesiveness of their texts. However, they should use another type of grammatical cohesion in their writing more often. Moreover, the role of the teacher in supplying information about another type of grammatical cohesion will give positive effect in their writing.