Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Otostegia persica (Burm.) Boiss on morphine withdrawal syndrome in mice

Effect of Otostegia persica on naloxone-induced morphine withdrawal syndrome was studied in male mice. Dependence was induced using daily subcutaneous injections of morphine for three days. Morphine was injected to mice at doses of 30 and 45mg/kg on day 1 and 60 and 90mg/kg on day 2 (8:00 am and 6:00 pm). On day 3, morphine (90mg/kg) was injected 1h before oral administration and 1.5h before intraperitoneal (i.p.) injection of hydroalcoholic and hexane extracts of the plant. Naloxone was injected (5mg/kg, i.p.) 2h after the final dose of morphine and the withdrawal signs including jumping, rearing, diarrhoea, piloerection, tremor and ptosis were recorded during a period of 30 minutes. While oral and i.p. administration of hydroalcoholic extract reduced the number of jumping and rearing, the hexane extract could not exert any significant change. Also the hydroalcoholic extract (1500mg/kg) significantly (p<0.05) reduced diarrhoea, piloerection, tremor and ptosis. The hexane extract only significantly (p<0.05 ) inhibited diarrhoea. Results of this study indicated that the extract of Otostegia persica contained component(s) that alleviate morphine withdrawal syndrome and the responsible constituent(s) is(are) found in polar fraction since the hexane extract had only a negligible effect.
Veteran Educators or For-Profiteers? Tuition Responses to Changes in the Post 9/11 GI Bill

In 2010, Congress reauthorized the Post-9/11 GI Bill by changing reimbursement rates from widely-varying by-state maximums to a nationwide limit. This policy created exogenous variation in the changes in reimbursement rates in direction and magnitude for veterans at private universities. We leverage this variation to examine for-profit college responses to changes in reimbursement rates. We detect tuition responses only for for-profit colleges, where we estimate a one percent pass-through rate. This for- profit response is driven by colleges in states that saw decreased benefits, colleges with higher concentrations of veterans, and colleges whose pre-change tuition was above the state maximum but below the since-increased nationwide level; the last group has a pass-through rate of eight percent. This policy also caused declines in non-veteran populations showing a substitution towards veteran students.
Effect of an essential oils blend on meat characteristics of crossbred heifers finished on a high-grain diet in a feedlot

Context Natural additives have been studied to increase animal performance and the quality of meat as alternatives to the use of antibiotics. Aims The present work investigated the effects of an essential oil blend (oregano, rosemary, lemon, garlic, eucalyptus, thyme and sweet orange) incorporated into the diet of crossbred heifers on the meat quality. Methods Thirty 12-month-old half-sister crossbred heifers (1/2 Angus vs 1/2 Nellore) with an average weight of 219.8 ± 8.8 kg were allocated in individual pens for 3 months. Three diets were tested: E0.0 (without the essential oil blend); E3.5 (with 3.5 g of the essential oil blend/animal.day); E7.0 (7.0 g of the essential oil blend/animal.day). The fatty acid composition (chemical) and profile of the Longissimus muscle were evaluated. In addition, the effect of aging (1, 7 and 14 days in vacuum packs at 2°C) on the colour, cooking and thawing losses, texture, and lipid oxidation were determined. Key results The essential oil blend did not affect (P > 0.05) the meat. It did not impact on the decrease in shear force, increased lipid oxidation or changes in colour with aging. Conclusions The chemical composition, water holding capacity, shear force, lipid oxidation, and fatty acid profile were not influenced by including the essential oil blend in the diet of heifers. Implications The use of low dosages of an essential oil blend could be applied in the diet of heifers, without affecting meat quality.
CONSUMER JOURNEY OF CULINARY PRODUCTS THROUGH SOCIAL MEDIA IN INDONESIA

Purpose of the study: This research was conducted with the aim of finding the pattern or model of the consumer journey, particularly the consumer decision-making processes for culinary products among the JKTFoodbang community on Instagram. Methodology: The method used in this research is a qualitative method in which this research emphasizes the meaning and process rather than the results of an activity. Main Findings: Social media is able to facilitate all stages in the consumer journey, particularly in the consumption process of culinary products. Applications of this study: This research will contribute to the knowledge of the concept in Indonesia and technology. The results of this study can be beneficial for marketers, society and stakeholders. Which is Social media is able to facilitate all. Novelty/Originality of this study: The diversity of information sources and content on social media provides more strength for consumers, particularly Millennials to make the consumption decisions of culinary products. Despite it has great potential, social media cannot stand alone in the context of facilitating all stages in the consumer journey, particularly for consumers of culinary products.
The Autonomic Repercussions of Fetal and Maternal Interaction in Pre-eclampsia

Abstract Pre-eclampsia (PE) is one of the severe complications of pregnancy that leads to fetal deterioration. The aim of the investigation was to determine the role of maternal respiratory sinus arrhythmia (RSA) in regulation of fetal circulatory system in case of healthy pregnancy and in PE. The investigation of maternal and fetal HRV and umbilical venous blood flow velocity spectral analysis in 106 patients at 34-40 weeks of gestation was performed. 30 of them had healthy pregnancy and were involved in the Group I. In Group II 44 pregnant women with mild-moderate PE were observed. 32 patients with severe PE were monitored in Group III. The maternal sympathetic overactivity modulated HRV in PE. The suppression of RSA was explored in preeclamptic patients. The Doppler spectrograms of the umbilical veinous blod flow had the oscillatory peak with a frequency about 0.5 Hz. The above peak characterized the participation of the maternal RSA in fetal hemodynamics. Strong relationship between maternal RMSSD and amplitude of RSA associated peak, maternal and fetal RMSSDs was found in healthy pregnancy. No considerable relationship was revealed between the maternal RMSSD and the amplitude of 0.5 Hz frequency peak, the maternal and fetal RMSSDs in the patients with severe PE. The maternal RSA propagated its influence on the fetal umbilical venous blood flow and the fetal autonomic nervous regulation in normal gestation. The control of fetal hemodynamics diminished in the mild-moderate PE and even disappeared in severe PE.
Activation of cryptic splicing in bovine WDR19 is associated with reduced semen quality and male fertility

Cattle are ideally suited to investigate the genetics of male reproduction, because semen quality and fertility are recorded for all ejaculates of artificial insemination bulls. We analysed 26,090 ejaculates of 794 Brown Swiss bulls to assess ejaculate volume, sperm concentration, sperm motility, sperm head and tail anomalies and insemination success. The heritability of the six semen traits was between 0 and 0.26. Genome-wide association testing on 607,511 SNPs revealed a QTL on bovine chromosome 6 that was associated with sperm motility (P = 2.5 x 10-27), head (P = 2.0 x 10-44) and tail anomalies (P = 7.2 x 10-49) and insemination success (P = 9.9 x 10-13). The QTL harbors a recessive allele that compromises semen quality and male fertility. We replicated the effect of the QTL on fertility (P = 7.1 x 10-32) in an independent cohort of 2481 Brown Swiss bulls. The analysis of whole-genome sequencing data revealed that a synonymous variant (BTA6:58373887C>T, rs474302732) in WDR19 encoding WD repeat-containing protein 19 was in linkage disequilibrium with the fertility-associated haplotype. WD repeat-containing protein 19 is a constituent of the intraflagellar transport complex that is essential for the physiological function of motile cilia and flagella. Bioinformatic and transcription analyses revealed that the BTA6:58373887 T-allele activates a cryptic exonic splice site that eliminates three evolutionarily conserved amino acids from WDR19. Western blot analysis demonstrated that the BTA6:58373887 T-allele decreases protein expression. We make the remarkable observation that, in spite of negative effects on semen quality and bull fertility, the BTA6:58373887 T-allele has a frequency of 24 % in the Brown Swiss population. Our findings are the first to uncover a variant that is associated with quantitative variation in semen quality and male fertility in cattle. Author summary In cattle farming, artificial insemination is the most commonly used method of breeding. To ensure high fertilization rates, ejaculate quality and insemination success are closely monitored in artificial insemination bulls. We analyse semen quality, insemination success and microarray-called genotypes at more than 600,000 genome-wide SNP markers in 794 bulls to identify a recessive allele that compromises semen quality. We take advantage of whole-genome sequencing to pinpoint a variant in the coding sequence of WDR19 encoding WD repeat-containing protein 19 that activates a novel exonic splice site. Our results indicate that cryptic splicing in WDR19 is associated with reduced male reproductive performance. This is the first report of a variant that contributes to quantitative variation in bovine semen quality.
Lipid peroxidation and antioxidant status in patients with type 2 diabetes in relation to obesity in Pokhara - Nepal

Obesity is a worldwide epidemic, associated with health related problems including type 2 diabetes. Diabetes is estimated to be responsible for 3.96 million adult deaths per year globally. The aim of this study was to determine lipid peroxidation and antioxidant status in patients with type 2 diabetes at a tertiary care hospital in relation to obesity in a section of Nepali population. Obesity is determined by the body mass index (BMI). Lipid peroxidation was determined by measurement of thiobarbituric acid reactive substances (TBARS) in plasma of the patients. The antioxidant status was estimated by determining the levels of vitamin C, vitamin E and total antioxidant activity in plasma. On BMI grading 49% male patients were of normal weight, 40% pre obese and 9.4% obese I and 2% were obese II. Similarly, among female patients 42% were normal, 45% pre obese, 5% were obese I and 8% were obese II. TBARS were increased in all the male patients except obese II. Vitamin E was decreased in male patients in normal BMI group and obese I but in female patients it was decreased in all the groups. Likewise, vitamin C was increased in all the groups in male patients and in female patients it was increased in the entire group, except pre obese. Severe obesity is rather uncommon in Nepal and in the present study it was absent in patients with type 2 diabetes. Conclusively, the results showed that male patients were relatively more prone to obesity and oxidative stress than females.
GC-MS analysis of the lipophilic compounds of medicinal plant Rhodiola rosea L.

Rhodiola (R.) rosea L. is one of the most popular adaptogenic agents. Rhodiola rosea L. (fam. Crassulaceae) commonly known as golden root or roseroot, is an insect-pollinated dioecious perennial that has been traditionally used as an immunomodulatory agent in many countries, including Kazakhstan. Plant extracts can be used both against somatic and infectious diseases, psychiatric and neurological diseases as well as in healthy people to relieve fatigue and increase concentration, memory, and productivity. There is growing evidence that the long-term effects of stressful life events and depression are associated with significant behavioral, endocrinological and neurobiological changes in human. R. rosea is a relatively rare and valuable medicinal plant and grows at high altitudes (up to 2280 m above the sea level) in the arctic and mountainous regions of Central Asia, Europe and North America. Study of the phytochemical composition of R. rosea is required in order to introduce it into official practice. Several mechanisms of action that are potentially responsible for the observed stress resistance, anti-aging and anti-cancer effects of R. rosea extracts and its active compounds have been identified in in vitro cell culture systems and on in vivo animal models. R. rosea extracts and its main biologically active compound salidroside appear to have multi-targeted effects. The results of our research showed that R. rosea in addition to adaptogenic, has several other pharmacological properties: antioxidant, antidepressant, immunomodulatory. Phytochemical study of R. rosea in Kazakhstan has been conducted for the first time. As a result of the conducted work, 28 compounds were identified in its composition.
Diez minutos de actividad física interdisciplinaria mejoran el rendimiento académico

espanolEl aumento del sedentarismo ha propiciado diferentes estrategias de promocion de la actividad fisica. Realizar ejercicio fisico en el aula puede ser una estrategia para mejorar el rendimiento academico y, al mismo tiempo, romper con los periodos de sedentarismo en los centros educativos. Por ello, el objetivo de este estudio piloto fue conocer el efecto de una intervencion interdisciplinar entre educacion fisica y una asignatura de aula. Participaron 116 estudiantes de ESO (50 chicas de 13.5 ± .7 anos; 66 chicos de 13.4 ± .7 anos). Al principio de las clases de una unidad didactica de lengua castellana y literatura, el grupo control de alumnos realizo 10 minutos de estudio-repaso sentados en sus sillas, mientras que el grupo experimental hizo 10 minutos de actividad fisica moderada y vigorosa en el aula relacionados con los contenidos de la misma unidad didactica. Antes y despues de la intervencion, ambos grupos cumplimentaron un examen con respuesta de eleccion multiple sobre los contenidos de la unidad didactica, The Strengths and Difficulties Questionnaire (SDQ) y el Cuestionario para la valoracion de la actividad fisica en escolares adolescentes. Se comprobo que realizar diez minutos de actividad fisica relacionados con los contenidos de un area curricular mejora el rendimiento academico (p EnglishThe increase in sedentary lifestyles has led to a number of strategies to promote physical activity. Doing physical exercise in the classroom could be a strategy to improve academic performance and break away from sedentary periods in schools. Thus, the objective of our pilot study was to learn about the effects of an interdisciplinary intervention between Physical Education and a classroom subject. 116 secondary education students (50 girls aged 13.5 ± .7 years and 66 boys aged 13.4 ± .7 years) took part. At the beginning of the Spanish Language and Literature teaching unit, the control group carried out 10 minutes of study and review seated in their chairs while the experimental group did 10 minutes of moderate to vigorous physical exercise related to the contents of the same teaching unit. Before and after the intervention, the participants completed a multiple- choice test about the teaching unit, The Strengths and Difficulties Questionnaire (SDQ), and the Questionnaire for Assessing Physical Activity in Teenage Schoolchildren. Doing ten minutes of physical activity related to the contents of a curricular area has been shown to improve academic performance (p
Knowledge Mobilization and Mental Health Policy: Lessons from the Canadian Consensus Conference on the Mental Health of Emerging Adults

This case study explores how the Consensus Conference on the Mental Health of Emerging Adults, hosted by the Mental Health Commission of Canada in 2015, can impact mental health policy and practice in Canada. The study draws on interviews from 14 delegates who attended the conference. Participants praised innovations such as the inclusion of an emerging adult panel that provided feedback on all discussions, and efforts to make the consensus-building process meaningful in the Canadian policy context. Findings suggest that consensus conferences are a promising way to operationalize the Mental Health Strategy for Canada through policy and practice changes.
Implementing a Participatory Human Rights-Based Research Methodology: The Unfitness to Plead Project

This article describes a novel action-research methodology that combines aspects of participatory methods and emancipatory principles into a human rights-based framework. The history of these different methods is discussed and the authors then explain how the methods can be combined to create a participatory human rights-based research methodology. This new methodology has the potential for high social impact, community inclusion, and scholarly output. The article also describes the implementation of the methodology on a project which analysed the human rights compliance of unfitness to plead laws in the Australian criminal justice system. This project developed a system of support persons within community legal centres across Australia in order to build an evidence-base for good practice in supporting people with cognitive disability who are charged with a crime. The new participatory human rights-based methodology was successful on this project and is replicable in future human rights research.
Big Data Analytics and Simulation for Better Strategic Management

Nowadays, technological innovations allow the connection between many devices through intelligent and interoperable nodes. This connection gives an ability to perform analytical processes in a real time for big data and makes enable many devices to work together in order to generate meaningful knowledge for systems. Therefore, the collection and analysis of big data has gained great importance in order to make vital strategic decisions. The emergence of big data has influenced strategic planning processes in both planning and implementation stages. Especially for companies that want to protect their assets for a long time and survive in the competition market, it is vital to use big data analytics tools. Therefore, the most important contribution of this study is that the big data structures and methodologies used in big data analytics have been examined in the context of strategic planning. n addition, the use and effectiveness of modeling and simulation approach in strategic decisions to be realized within the scope of big data are discussed. The study is aimed to provide insight for researchers working on strategic planning and big data
Midwives and obstetricians

This occasional column will draw upon archival material; its title, ‘obstetrix’ is the Latin term for ‘midwife’. It is important to be aware of the inevitable link between the work of the midwife and that of the obstetrician, and to realise that in the past, their roles have been blurred.
Synergy between parasitoids and pathogens for biological control of Helicoverpa armigera in chickpea

The chickpea pod borer, Helicoverpa armigera Hübner (Lepidoptera: Noctuidae), is an important pest of many legume crops, including chickpea, Cicer arietinum L. (Fabaceae). We field‐tested the efficacy of two pathogens, Helicoverpa armigera nucleopolyhedrosis virus (HaNPV) and Bacillus thuringiensis Berliner subsp. kurstaki (Btk), both alone and in combination with the parasitoid Habrobracon hebetor Say (Hh) (Hymenoptera: Braconidae), for control of H. armigera larvae in chickpea fields. A randomized complete block design was used at two sites, so that wasp release treatments at one site would not contaminate pathogen‐only treatments at the other. Pathogens were applied when most pest larvae were in the second instar, and wasp releases were made 2 days later. Number of H. armigera larvae per plant, number of damaged pods, yield (kg ha−1), treatment cost (US$ ha−1), and benefit:cost ratio were all determined. Treatments separated significantly at 14 days after treatment, with the HaNPV+Hh and Btk+Hh treatments providing the best control, suggesting a synergistic impact of the wasp and the pathogens when applied together. These treatments also produced the fewest damaged pods, the highest yields, and the greatest yield increments in comparison to untreated controls. However, costs were also highest for these combined treatments, which reduced their net benefit in comparison to use of Hh or Btk alone, although more efficient mass production of the pathogens might make combined applications feasible. We conclude that both HaNPV and Btk are suitable for integration with releases of H. hebetor against H. armigera in chickpea fields, provided parasitoid releases are delayed until 2 days after pathogen application.
The role of coarse aerosol particles as a sink of HNO3 in wintertime pollution events in the Salt Lake Valley

Abstract. Wintertime ammonium nitrate (NH4NO3) pollution events burden urban mountain basins around the globe. In the Salt Lake Valley of Utah in the United States, such pollution events are often driven by the formation of persistent cold-air pools (PCAPs) that trap emissions near the surface for several consecutive days. As a result, secondary pollutants including fine particulate matter less than 2.5 µm in diameter (PM2.5), largely in the form of NH4NO3, build up during these events and lead to severe haze. As part of an extensive measurement campaign to understand the chemical processes underlying PM2.5 formation, the 2017 Utah Winter Fine Particulate Study, water-soluble trace gases and PM2.5 constituents were continuously monitored using the ambient ion monitoring ion chromatograph (AIM-IC) system at the University of Utah campus. Gas-phase NH3, HNO3, HCl, and SO2 along with particulate NH4+, Na+, K+, Mg2+, Ca2+, NO3-, Cl−, and SO42- were measured from 21 January to 21 February 2017. During the two PCAP events captured, the fine particulate matter was dominated by secondary NH4NO3. The comparison of total nitrate (HNO3 + PM2.5 NO3-) and total NHx (NH3 + PM2.5 NH4+) showed NHx was in excess during both pollution events. However, chemical composition analysis of the snowpack during the first PCAP event revealed that the total concentration of deposited NO3- was nearly 3 times greater than that of deposited NH4+. Daily snow composition measurements showed a strong correlation between NO3- and Ca2+ in the snowpack. The presence of non-volatile salts (Na+, Ca2+, and Mg2+), which are frequently associated with coarse-mode dust, was also detected in PM2.5 by the AIM-IC during the two PCAP events, accounting for roughly 5 % of total mass loading. The presence of a significant particle mass and surface area in the coarse mode during the first PCAP event was indicated by size-resolved particle measurements from an aerodynamic particle sizer. Taken together, these observations imply that atmospheric measurements of the gas-phase and fine-mode particle nitrate may not represent the total burden of nitrate in the atmosphere, implying a potentially significant role for uptake by coarse-mode dust. Using the NO3- : NH4+ ratio observed in the snowpack to estimate the proportion of atmospheric nitrate present in the coarse mode, we estimate that the amount of secondary NH4NO3 could double in the absence of the coarse-mode sink. The underestimation of total nitrate indicates an incomplete account of the total oxidant production during PCAP events. The ability of coarse particles to permanently remove HNO3 and influence PM2.5 formation is discussed using information about particle composition and size distribution.