Miracle-dz/UniFAR-FTUs huggingface dataset:
Goal setting with caregivers of adults in the community: a mixed methods systematic review

Abstract Purpose: To examine how goal setting is used with caregivers of community residing adults and the effect of goal setting practices in improving the outcomes. Methods: A mixed methods systematic review was conducted. The methodological rigour of included studies was critiqued using Cochrane Collaboration’s risk of bias assessment tool, Downs and Black checklist and a framework for evaluating qualitative research. Narrative synthesis was created through tabulation and categorisation, visual mapping of the goal setting process, thematic analysis on common goal setting features and critical reflection on the accuracy and robustness of the synthesis. Results: Seventeen studies were included: 10 randomised trials, 5 other quantitative studies and two descriptive studies which incorporated qualitative methods. The trials demonstrated a relatively low risk of bias in contrast to the other studies that had varied methodological rigour. No studies isolated the effect of the goal setting process on outcomes and therefore the effectiveness of goal setting could not be evaluated. However, through a narrative synthesis six prominent features of collaborative goal setting were identified. Conclusions: Despite the fact that goal setting is an important component of client-centred care, and the prominence of client-centred care in healthcare discourse, the review uncovered a surprisingly limited number of studies. Goal setting is an elusive process that is of therapeutic value and warrants further investigation. Implications for Rehabilitation The current body of empirical evidence suggests that there are six prominent features of collaborative goal setting with caregivers. The goals that are most important to caregivers are often different to those that are important to clinicians; it is important that caregivers and clinicians agree on goals to maximise adherence to treatment and goal attainment. The quality of evidence for goal setting with caregivers is limited although some intervention trials illustrate the usefulness of collaborative goal setting in contributing to improved outcomes.
Estrogen Receptor α, Fos-Related Antigen-2, and c-Jun Coordinately Regulate Human UDP Glucuronosyltransferase 2B15 and 2B17 Expression in Response to 17β-Estradiol in MCF-7 Cells

UDP-glucuronosyltransferase 2B15 and 2B17 expression is up-regulated by 17β-estradiol in MCF-7 breast cancer cells, as assessed by quantitative real-time polymerase chain reaction. Using 5′-deletion mapping and site-directed mutagenesis, we demonstrate that 17β-estradiol activation of UGT2B15 gene transcription is mediated by a 282-base pair fragment positioned -454 to -172 nucleotides from the translation start site. This region contains two putative activator protein-1 (AP-1) elements, one imperfect estrogen response element (ERE), and two consensus ERE half-sites. We propose that these five sites act as an estrogen response unit (ERU), because mutation in any site reduces activation of the UGT2B15 promoter by 17β-estradiol. Despite the presence of two AP-1 elements, the UGT2B15 promoter is not responsive to the AP-1 activator phorbol 12-myristate 13-acetate. Although electrophoretic mobility shift assays (EMSA) indicate that the AP-1 proteins c-Jun and Fos-related antigen 2 (Fra-2) bound to the distal AP-1 site, binding of Jun or Fos family members to the proximal AP-1 site was not detected by EMSA. Chromatin immunoprecipitation assays showed a 17β-estradiol-induced recruitment of estrogen receptor (ER) α, c-Jun, and Fra-2 to the 282-bp ERU. The involvement of these three transcription factors in the stimulation of UGT2B15 gene expression by 17β-estradiol was confirmed by siRNA silencing experiments. Mutagenesis and siRNA experiments indicate that UGT2B17 expression is also regulated by 17β-estradiol via the ERU, which is fully conserved in both promoters. Because UGT2B15 and UGT2B17 inactivate steroid hormones by glucuronidation, the regulation of their genes by 17β-estradiol may maintain steroid hormone homeostasis and prevent excessive estrogen signaling activity.
Phlogiston theory and chemical revolutions

Priestley is famous among scientists mainly for his discovery of oxygen, but he also achieved many other great “firsts” in science. In this presentation, emphasis will be placed on that aspect of his work for which he became “infamous”. Priestley adopted, developed, and advanced the theory of phlogiston to explain why materials react with oxygen. He continually had to refine the theory, but in the end, he died ignominiously in the eyes of the developing community of chemical scientists. To his dying day, he refused to acknowledge the nonexistence of phlogiston as the driving force for chemical reactions.
Long-term maintenance of species-specific bacterial microbiota in the basal metazoan Hydra

Epithelia in animals are colonized by complex communities of microbes. Although a topic of long-standing interest, understanding the evolution of the microbial communities and their role in triggering innate immune responses has resisted analysis. Cnidaria are among the simplest animals at the tissue grade of organization. To obtain a better understanding of the microbiota associated with phylogenetically ancient epithelia, we have identified the epibiotic and endosymbiotic bacteria of two species of the cnidarian Hydra on the basis of rRNA comparisons. We analyzed individuals of Hydra oligactis and Hydra vulgaris from both laboratory cultures and the wild. We discovered that individuals from both species differ greatly in their bacterial microbiota. Although H. vulgaris polyps have a quite diverse microbiota, H. oligactis appears to be associated with only a limited number of microbes; some of them were found, unexpectedly, to be endosymbionts. Surprisingly, the microfauna showed similar characteristics in individuals of cultures maintained in the laboratory for >30 years and polyps directly isolated from the wild. The significant differences in the microbial communities between the two species and the maintenance of specific microbial communities over long periods of time strongly indicate distinct selective pressures imposed on and within the epithelium. Our analysis suggests that the Hydra epithelium actively selects and shapes its microbial community.
Erythrocyte vesiculation: a self‐protective mechanism?

Previous studies demonstrated that 20% of haemoglobin is lost from circulating erythrocytes during their total lifespan by vesiculation. To study whether removal molecules other than membrane‐bound haemoglobin were present in erythrocyte‐derived vesicles, flow cytometry and immunoblot analysis were employed to examine the presence of phosphatidylserine (PS) and IgG, and senescent cell antigens respectively. It was demonstrated that 67% of glycophorin A‐positive vesicles exposed PS, and that half of these vesicles also contained IgG. Immunoblot analysis revealed the presence of a breakdown product of band 3 that reacted with antibodies directed against senescent erythrocyte antigen‐associated band 3 sequences. In contrast, only the oldest erythrocytes contained senescent cell antigens and IgG, and only 0·1% of erythrocytes, of all ages, exposed PS. It was concluded that vesiculation constitutes a mechanism for the removal of erythrocyte membrane patches containing removal molecules, thereby postponing the untimely elimination of otherwise healthy erythrocytes. Consequently, these same removal molecules mediate the rapid removal of erythrocyte‐derived vesicles from the circulation.
Dark matter indirect signals with long-lived mediators

Dark matter particles could annihilate into light and metastable mediators subsequently decaying far away from where they are produced. In this scenario, the indirect signatures of dark matter are altered with respect to the conventional situation where standard model particles are directly injected where annihilation happens. We revisit the long-lived particle proposal (Rothstein et al., 2009) and devise the tools to explore this new phenomenology. We calculate the effective dark matter distribution resulting from the smearing by mediator propagation. We derive general expressions for the fluxes of mediators and their decay particles. We study how the J-factor, which naturally appears in the calculation of the dark matter induced gamma ray signal, is modified in the presence of mediators. We also derive the anisotropy which the cosmic ray positron flux exhibits in this scenario. We finally comment upon a recent proposal based on long-lived mediators where the effective dark matter density at the Earth is increased such as to explain the cosmic ray positron anomaly. We conclude that this scenario is barely tenable as regards the very dense dark matter spike which it requires at the Galactic center. The associated positron anisotropy is very small and undetectable, except at high energies where it reaches a level of order 10−4 to 10−3.
Algorithmes d'approximation garantie pour l'ordonnancement de tâches

Cette these est consacree a l'etude des problemes d'ordonnancement d'une application parallele decrite par un graphe de precedence avec delais de communication. Les problemes d'ordonnancement etant dans leur grande majorite NP-difficiles, nous presentons une approche par algorithmes d'approximation dont nous determinons les garanties de performance par rapport a une solution optimale. L'objectif de l'ordonnancement est la minimisation du temps d'execution de l'application. Afin de reduire l'impact des communications dans les performances des heuristiques, nous envisageons deux approches, par un regroupement preliminaire des tâches et par l'utilisation de la duplication. Pour le probleme du regroupement nous proposons une extension de l'algorithme DSC construisant des suites iterees de regroupements lineaires, convergeant pour des structures simples de graphes vers la solution optimale. Nous proposons egalement un algorithme d'ordonnancement avec duplication de garantie 2 pour les probleme a petits temps de communication sur un nombre limite de processeurs, base sur un algorithme de liste. Pour les problemes a grands temps de communication nous etablissons le gain, mais aussi les limitations, de cette approche, en montrant que tout algorithme de liste avec duplication possede une garantie en Θ(√ρ), ρ designant la granularite du graphe. Nous etudions finalement une generalisation du modele d'execution dans lequel chaque tâche, dite malleable, peut s'executer sur un nombre quelconque de processeurs. Un algorithme de garantie √3 est propose pour l'ordonnancement de tâches malleables independantes. Nous concluons cette these par quelques perspectives sur l'ordonnancement dynamique dans ce modele
SDPP: an intelligent secure detection scheme with strong privacy-preserving for mobile peer-to-peer social network

In this paper, we propose an intelligent secure detection scheme with strong privacy-preserving, called SDPP, for improving routing security and achieving privacy preservation of message in mobile peer-to-peer social network (MP2PSN). Specifically, in the proposed SDPP scheme, each user is granted with a pseudo-ID, a certificate, and its private key corresponding to his similar interests. Based on the cooperative neighbour technique and the homomorphic encryption method, the proposed SDPP scheme cannot only detect and avoid black hole attacks but it also can preserve the message privacy. Through security analysis, we show that the proposed scheme is secure in the MP2PSN scenarios. Moreover, we also discuss how SDPP can achieve the privacy-preservation of message and the evolution of users' certificates. Both theoretical and simulation results are given to demonstrate the effectiveness of the proposed scheme in terms of black hole detection rate, average Detectreq reporting, and average transmission delay under various scenarios.
Increased ethanol self-administration in delta-opioid receptor knockout mice.

BACKGROUND The role of the delta-opioid receptor in ethanol drinking has remained unclear despite the use of traditional pharmacological and correlational approaches. The results of several studies suggest that pharmacological blockade of these receptors results in decreases in ethanol drinking behavior, but an approximately equal number of reports have failed to observe an effect of delta-receptor antagonism on ethanol drinking. It is clear that alternative approaches to understanding opioid-receptor involvement in ethanol drinking are needed. METHODS In this study, ethanol drinking was examined in delta-opioid receptor knockout (KO) mice by using first a two-bottle-choice test, then an operant self-administration paradigm and a second two-bottle-choice test, in that order. In addition, because KO mice were previously shown to display enhanced anxiety-like behavior relative to wild-type (WT) mice, the effect of ethanol self-administration on anxiety-like responses was determined. RESULTS delta KO mice initially showed no evidence of a preference for ethanol in the first two-bottle-choice drinking test; however, after an experience of operant self-administration of ethanol, a preference for ethanol developed in the second two-bottle-choice test. KO mice also showed a preference for ethanol over water and self-administered more ethanol than WT mice in the operant self-administration paradigm. The ethanol self-administered in this procedure was sufficient to reverse the innate anxiety-like response observed in this strain. CONCLUSIONS delta KO mice showed a greater preference for ethanol and consumed more ethanol than their WT counterparts, suggesting that a decrease in delta-receptor activity is associated with increased ethanol-drinking behavior. It is hypothesized that delta receptors may influence ethanol self-administration at least partly through an effect of these receptors on anxiety-like behavior.
Análisis didáctico y formación inicial de profesores: competencias y capacidades en el aprendizaje de los escolares

Describimos aquí parte de una investigación en la que se analiza el proceso de reflexión que realizaron los estudiantes de último año de Matemáticas sobre cuestiones profesionales relativas a la enseñanza de las matemáticas, que surgieron durante sus prácticas de enseñanza. Caracterizamos la reflexión de los estudiantes a partir de una serie de dimensiones: ideas y creencias, autoridad, consideración del contexto, situaciones problemáticas y uso del conocimiento. En este artículo trataremos el modo en que los estudiantes usaron el conocimiento profesional cuando tuvieron que impartir una clase a sus compañeros sobre la cuestión profesional ¿Cómo evaluar un ejercicio/examen? Using Professional Knowledge in Reflection Processes in Initial Secondary Teachers Training We describe part of a research study in which we analyzed the process of reflection of last year mathematics students. This reflection process is based on professional questions about mathematics teaching which emerged during their teaching practice. We characterize students´ process of reflection by using a set of dimensions: ideas and beliefs, authority, context consideration, problematic situations and use of knowledge. In this article we focus on how students used professional knowledge when they had to teach a lesson to their partners about the professional question How to evaluate a task/test? Handle: http://hdl.handle. net/10481/4219Nº de citas en WOS (2017): 7 (Citas de 2º orden, 3)Nº de citas en SCOPUS (2017): 2 (Citas de 2º orden, 3)
INTEGRATION OF SENSOR NETWORKS IN CLOUD COMPUTING

The paper proposes a framework for supporting cost-effective cloud computing for intensive sensor utilization using a dedicated Sensor-Cloud Infrastructure (SCI). SCI virtualizes a physical sensor as a virtual sensor on the cloud computing. Dynamic grouped virtual sensors on cloud computing can be automatic provisioned on users request. Several configurations of virtual sensor groups are discussed, as well as some particular security policies. Finally, the advantages, but also the drawbacks of the proposed solution are presented.
Potency of parenteral antimicrobials including ceftolozane/tazobactam against nosocomial respiratory tract pathogens: considerations for empiric and directed therapy.

BACKGROUND Empiric therapy decisions are predicated on knowledge of both the epidemiology and antimicrobial susceptibility of the probable infecting pathogen(s). The objective of this study was to evaluate the microbial distribution and phenotypic profiles of nosocomial respiratory isolates collected from multiple US hospitals and assess the clinical utility of various monotherapy and combination regimens. METHODS Hospitals provided consecutive non-duplicate adult inpatients Gram-negative nosocomial respiratory isolates from cultures received ≥48 h after hospital admission. Minimum inhibitory concentrations (MICs) for 12 antimicrobials were determined using broth microdilution methods. An antibiogram was constructed for monotherapy regimens as well as combinations inclusive of either tobramycin (TOB) or ciprofloxacin (CIP). RESULTS Six hospitals provided 518 nosocomial respiratory isolates. P. aeruginosa (PSA) comprised 28% of the population followed by Klebsiella pneumoniae (13%), Enterobacter spp. (13%), S. maltophilia (9%), S. marcesens (6%), A. baumannii (6%), and others (18%). When considering monotherapy for the Enterobacteriaceae & PSA ceftolozane/tazobactam (C/T) provided the highest (87%) percent susceptibility (%S) followed by meropenem (MEM), CIP, cefepime (FEP), ceftazidime (CAZ) and piperacillin-tazobactam (TZP) at 71-85%S. The addition of TOB > CIP improved the probability that the antimicrobial combination would provide ≥1 active agent. CONCLUSIONS PSA was the predominant nosocomial respiratory pathogen; however, the Enterobacteriaceae comprised an additional 53% in this survey. When considering empiric β-lactam monotherapy therapy for the entire spectrum of pathogens C/T provided the highest (78%) %S followed by MEM, FEP and TZP. The addition of either TOB > CIP to these β-lactams enhances the likelihood that an active agent would be selected when considering empirical therapy choices for nosocomial respiratory tract infections.
Effect of different chelating solutions on the push-out bond strength of various root canal sealers

Objective: The aim of this paper was to evaluate the effects of four final irrigation solutions, on bond strength to radicular dentin of three root canal sealers based on calcium silicate and resin. Methods: This study used 96 extracted mandibular premolars. The teeth were sectioned transversally to obtain two sections. The resulting 192 samples were randomly divided into four irrigation groups: Group 1 was irrigated with 17% EDTA and 5.25% NaOCl; Group 2 with QMix; Group 3 with 0.2% chitosan solution; and Group 4 with distilled water. After these irrigation procedures, three specimens from each group were randomly chosen for SEM examination. Then, remaining teeth were randomly divided into three subgroups (n=15), according to the sealer used: AH Plus, MTA Fillapex, and Total Fill BC Sealer. A vertical load was applied using a universal testing machine. All statistical analyses were performed with the SPSS (ver. 20.0) software. The results were analysed with a One-Way Analysis of Variance (ANOVA) and a post-hoc Tukey’s test (p ≤ 0.05). Results: AH Plus and Total Fill BC Sealer provided equal bond strengths to the root canal wall in all the groups except the distilled water group (p 0.05). When chitosan was used, all root canal sealers showed their highest bond strength values. Conclusions: Chitosan may serve as an alternative chelating agent for use with various root canal sealers.
The three‐dimensional microanatomy of the rabbit and human cornea. A chemical and mechanical microdissection‐SEM approach

The three‐dimensional (3D) microanatomy of the cornea is the major determinant of its optical and mechanical properties. Scanning electron microscopy (SEM) is the most commonly used method to obtain information on the overall 3D microanatomy of organs. However, SEM has not been successful in revealing the 3D microanatomy of the cornea, because the interior of the cornea is too compact to be explored by the electron beam. In this study, the 3D organisation of the cells and extracellular materials of human and rabbit corneas was examined after exposure by HCl and NaOH digestion, and by microdissection by the adhesive tape method. In the cornea of both species, all epithelial cells exhibited microplicae regardless of their location. This raises doubts about the tear film‐holding role assigned to the microplicae of the superficial cells. Human and rabbit corneas differed in the collagen fibre patterns of the epithelial basement membranes. The 3D organisation of the stromal lamellae was similar in both species. In humans and rabbits, the keratocytes showed similar 3D features. However, the surface of human keratocytes located near Descemet's membrane exhibited small fenestrations that were not present in the rabbit keratocytes. The pattern of keratocyte innervation by the stromal neural plexus and 3D keratocyte microanatomy confirms that keratocytes form a large intercommunicating network within the corneal stroma. Two morphologically discrete subpopulations of keratocytes located at different stromal levels were identified in both human and rabbit corneas, suggesting that keratocytes are not functionally homogeneous. In addition, the density of the stromal neural plexus appeared to be greater in rabbits than in humans. Clear differences between human and rabbit corneas were observed in the collagen arrangement in Descemet's membrane, which may reflect their different biomechanical requirements.
Internet Measurement: Infrastructure, Traffic and Applications

Acknowledgments. I. BACKGROUND. 1. Introduction. 1.1 Why Measure The Internet? 1.2 How to Read This Book. 1.3 Resources for More Information. 2. Internet Architecture. 2.1 The Internet's Architecture. 2.2 Details of Internet Operation. 2.3 Protocols. 2.4 Applications. 3. Analytic Background. 3.1 Linear Algebra. 3.2 Probability. 3.3 Statistics. 3.4 Graphs. 3.5 Metrics. 3.6 Measurement and Modelling. 4. Practical Issues in Internet Measurement. 4.1 Where Can Measurements Be Made? 4.2 Role of Time in Measurements. II. IN DEPTH. 5. Infrastructure. 5.1 Properties. 5.2 Challenges. 5.3 Tools. 5.4 State of the Art. 6. Traffic. 6.1 Properties. 6.2 Challenges. 6.3 Tools. 6.4 State of the Art. 7. Applications. 7.1 Application Mix. 7.2 DNS. 7.3 Web. 7.4 P2P. 7.5 Online Games. 7.6 Other applications. III. IN PERSPECTIVE. 8 Anonymization. 8.1 Definitions. 8.2 General Motivation for Anonymizing Data. 8.3 Obstacles and Risks in Sharing Data. 8.4 Categorizing Data: What Should be Anonymized? 8.5 Anonymizing Process and Techniques: How data is Anonymized. 8.6 Anonymization Examples at Different Layers. 8.7 Attacks Against Anonymized Data. 8.8 Anonymizing Data: Metrics for Success. 8.9 Alternatives to Anonymization. 9. Security. 9.1 Role of Internet Measurement in Security. 9.2 Intranet Measurements in Aid of Security. 9.3 Gateway Measurements in Aid of Security. 9.4 Inter-domain Measurements Impact on Security. 9.5 Wide-area Measurements in Aid of Security. 9.6 Application-level Measurements of Attacks. 10. Case Studies. 10.1 Low Level Monitoring Tools. 10.2 Individual Toolsets for Network Measurement. 10.3 Large Scale Measurement Projects. 11. Conclusions and Prospects. 11.1 Trends in Internet Measurement. 11.2 Difficulties. 11.3 Future Work. Bibliography. Index.