Miracle-dz/UniFAR-FTUs huggingface dataset:
A new spectroscopic phenomenon in fatty acid metabolism. The conversion of "pro-absorptive" to "absorptive" acids in the cow.

IN an accompanying communication [Booth et al., 1935] we have reported that when the cow is turned out to pasture after the winter the fatty acids obtained from the butter fat show greatly increased absorption for radiation ofwave length 230mlL. The work described in the present paper owes its origin to an attempt to correlate this increased absorption with the marked fall in the amount of fat in the milk which, as is already known, also frequently occurs when the cow first obtains access to green pasture. Now past work has shown that the feeding of cod-liver oil likewise causes a marked diminution in the amount of butter fat in the milk [Drummond et al., 1924]. Further, cod-liver oil was reputed to yield acids having very high absorption for radiation of wave length 230m,u [Gillam et al., 1931]. It seemed possible, therefore, that the depression of the fat might be linked up with the presence in it of highly absorbing1 acids, derived either from grass or from cod-liver oil. This explanation in its simplest form was ruled out when it was found by Dann and Moore [1933] that the high absorption of the fatty acids of codliver oil, recorded by Gillam et al., is not observed if the acids are prepared by a brief saponification, but only after the acids have been submitted to prolonged treatment with the hot alkali. It remained possible, nevertheless, that acids which resembled those of cod-liver oil in showing increased absorption after suitable treatment might exert a similar depressing influence on the amount of fat in milk. Support for this view was afforded by early experiments in which we found that the absorption of the butter fat was indeed greatly increased when the relatively non-absorbing cod-liver oil was fed to the cows. Further experiments have shown that fats capable of depressing the milk fat certainly do as a general rule possess unusual potency in raising the absorption at 230m,. The same property, however, is shared, if in a less degree, by other fats possessing no noticeable depressing action. The increase of absorption would indeed appear to be of a general character. It may occur in two ways, either in
Power and collaborative climate : building competitive advantage through flexibilities

In a buyer-supplier relationship (BSR), how is a manufacturer’s power related to its collaborative supplier climate and how do these two governance mechanisms simultaneously influence a firm’s performance? Evaluating 201 responses from senior manufacturing indicates that power and collaborative climate are positively related. A manufacturing firm’s power positively impacts cost and non-cost competitive advantage and is fully mediated by the firm’s flexibility. When flexibility exists, a manufacturer’s collaborative climate positively influences non-cost advantage and flexibility, with only an indirect impact on cost. This suggests that manufacturing companies need both power and a collaborative climate to sustainably improve overall performance.
Pulmonary hypertension in children: A historical overview

Pulmonary arterial hypertension in children contributes significantly to morbidity and mortality in diverse pediatric cardiac, lung, hematologic, and other diseases. Pulmonary arterial hypertension is generally a disease of small pulmonary arteries characterized by vascular narrowing due to high-tone and abnormal vasoreactivity, structural remodeling of the vessel wall, intraluminal obstruction, and decreased vascular growth and surface area. Without therapy, high pulmonary vascular resistance contributes to progressive right ventricular failure, low cardiac output, and death. Advances in basic pulmonary vascular biology over the last few decades have led directly to several novel therapies, which have significantly expanded therapeutic choices and have led to improved survival and quality of life of many children with pulmonary arterial hypertension. Despite these improvements, long-term outcomes in many settings remain guarded and substantial challenges persist, especially with regard to understanding mechanisms and approach to structural remodeling of severe pulmonary arterial hypertension.
Signed Cycle Double Covers

The cycle double cover conjecture states that every bridgeless graph has a collection of cycles which together cover every edge of the graph exactly twice. A signed graph is a graph with each edge assigned by a positive or a negative sign. In this article, we prove a weak version of this conjecture that is the existence of a signed cycle double cover for all bridgeless graphs. We also show the relationships of the signed cycle double cover and other famous conjectures such as the Tutte flow conjectures and the shortest cycle cover conjecture etc.
The effect of source of fiber on ileal and fecal amino acid digestibility and bacterial nitrogen excretion in growing pigs.

Studies were carried out with six barrows (initial BW 50 kg) to determine the effect of two fiber sources on the apparent ileal and fecal N and amino acid digestibilities and bacterial N excretion in feces. The pigs, fitted with a simple T-cannula at the distal ileum, were fed three cornstarch-based diets formulated to contain 16% CP from soybean meal according to a repeated 3 x 3 Latin square design. Diet 1 did not contain additional fiber. Diets 2 and 3 contained 10% powdered cellulose and 10% barley straw (ground through a 2-mm mesh screen), included at the expense of cornstarch, respectively. The pigs were fed 900 g at each meal twice daily, 0800 and 2000. Feces were collected for 48 h after a 10-d adaptation period. Thereafter, ileal digesta were collected for 24 h. Chromic oxide was used as a digestibility marker. With the exception of leucine, the inclusion of fiber did not affect (P greater than .05) the ileal digestibilities of the indispensable amino acids. The values for the average of the ileal digestibilities of the indispensable amino acids were 85.3, 82.9, and 83.2% for diets 1, 2, and 3, respectively. On the other hand, the inclusion of fiber decreased (P less than .05) the fecal digestibilities of all the indispensable amino acids. The values for the average of the fecal digestibilities of the indispensable amino acids were 91.7, 87.4, and 89.1% for diets 1, 2, and 3, respectively. These decreases resulted from an increase (P less than .05) in the excretion of bacterial N, which was measured using 2,6-diaminopimelic acid as a marker. In conclusion, as measured with the ileal analysis method, the inclusion of fiber had little effect on the digestible amino acid supply.
Impact of the Expanded Criteria Donor Allocation System on the Use of Expanded Criteria Donor Kidneys

Background. The U.S. Organ Procurement and Transplantation Network recently implemented a policy allocating expanded criteria donor (ECD) kidneys by waiting time alone. ECD kidneys were defined as having a risk of graft failure ≥1.7 times that of ideal donors. ECDs include any donor ≥60 years old and donors 50 to 59 years old with at least two of the following: terminal creatinine >1.5 mg/dL, history of hypertension, or death by cerebrovascular accident. The impact of this policy on use of ECD kidneys is assessed. Methods. The authors compared use of ECD kidneys recovered in the 18 months immediately before and after policy implementation. Differences were tested using t test and &khgr;2 analyses. Results. There was an 18.3% increase in ECD kidney recoveries and a 15.0% increase in ECD kidney transplants in the first 18 months after policy implementation. ECD kidneys made up 22.1% of all recovered kidneys and 16.8% of all transplants, compared with 18.8% (P<0.001) and 14.5% (P<0.001), respectively, in the prior period. The discard rate was unchanged. The median relative risk (RR) for graft failure for transplanted ECD kidneys was 2.07 versus 1.99 in the prepolicy period (P=not significant); the median RR for procured ECD kidneys was unchanged at 2.16. The percentage of transplanted ECD kidneys with cold ischemia times (CIT) <12 hr increased significantly; the corresponding percentage for CIT ≥24 hr decreased significantly. Conclusions. The recent increase in ECD kidney recoveries and transplants appears to be related to implementation of the ECD allocation system.
Receptive field properties of ON- and OFF-ganglion cells in the mouse retina

Abstract There are two subclasses of alpha cell in the mammalian retina, which are morphologically identical in plain view but have opposite responses to a luminance change: one is ON center and the other is OFF center. Recent studies have shown that the neural circuitries, which underlie light responses in such ON- and OFF-ganglion cell pairs, are not mirror symmetric with respect to the ON and OFF pathways (Pang et al., 2003; Zaghloul et al., 2003; Murphy & Rieke, 2006). This study examines alpha-cell homologues in the mouse retina and elucidates the synaptic mechanisms that generate their light responses. Morphological analysis of recorded cells revealed three subclasses that were essentially identical in plan view but had distinct vertical stratification levels. We refer to these cells as the sustained ON (ON-S), sustained OFF (OFF-S), and transient OFF (OFF-T) cells (Murphy & Rieke, 2006; Margolis & Detwiler, 2007). Both ON-S and OFF-S cells were largely driven through the ON pathway via changes in excitatory and inhibitory inputs, respectively. Light responses of OFF-T cells were driven by transient changes in excitatory and inhibitory inputs. Light responses of OFF-S cells were also measured in connexin 36 knockout mice in order to dissect glycinergic input arising from AII amacrine cells. At photopic/mesopic intensities, peak glycinergic input to OFF-S cells in the connexin 36 knockout mouse was reduced by ~85% compared to OFF-S cells in the wild-type retina. This is consistent with the idea that AII cells receive their input from ON-cone bipolar cells through gap junctions and in turn provide glycinergic inhibition to OFF-S cells.
Avian cecum: role of glucose and volatile fatty acids in transepithelial ion transport.

In the fowl cecum in vitro, the influence of glucose and the three most prevalent naturally occurring volatile fatty acids (acetate, propionate, butyrate) on short-circuit current (Isc), electrical resistance, and transport of Na and Cl was determined. When glucose, acetate, or butyrate was present, ion transport was characterized by electrogenic Na absorption, greater than 65% of which was amiloride inhibitable, and Cl secretion, which also was electrogenic. Isc could be completely accounted for by net fluxes of Na and Cl. When glucose, acetate, or butyrate (10 mM both sides) was included in the incubation medium, cecal tissue maintained its Isc and a constant rate of net Na absorption and Cl secretion for a 5-h period. When no substrate was present or propionate was included in the medium, a marked fall in Isc and net Na and Cl fluxes was seen. Glucose caused an increase in Isc when added only to the serosal side. As 3-O-methylglucose (not metabolized) was not effective in stimulating Isc of the cecum (serosal or mucosal addition), it appeared that glucose increased Isc by acting as an energy substrate for active Na transport. Acetate and butyrate appeared to be equally effective in stimulating Na transport and Isc when placed on either side of the membrane. When the preparation was supplied with glucose (serosal side) and acetate was added to the mucosal side, no further stimulation of Isc occurred. Thus it appeared that acetate and butyrate were acting as substrates for active Na transport rather than stimulating Na transport by some other mechanism such as a cotransport with Na. (ABSTRACT TRUNCATED AT 250 WORDS)
The architecture of first trimester chorionic villous vascularization: a confocal laser scanning microscopical study.

BACKGROUND The aim of this study was to investigate normal chorionic villous vascularization using CD31 immunofluorescence and confocal laser scanning microscopy (CLSM) to elucidate the spatial arrangement in terms of connections between vessels and cords and their branching patterns compared to deficient chorionic villous vascularization in complicated pregnancies. METHODS A descriptive morphologic study using CLSM after CD31 immunofluorescence staining of placental biopsies from normal pregnancies (n = 20), complete hydatidiform molar pregnancies (CHMs; n = 3) and empty sacs (n = 3), with a well documented gestational age (GA). RESULTS In this three-dimensional study, first trimester chorionic villi were occupied by a complex network of mainly cords with redundant connections as early as 5(+5) weeks GA. With increasing GA cords transform into vessels. From about 9 weeks GA onwards, vascular development is characterized by the presence of two large vessels located centrally and surrounded by and connected to a capillary network. In first trimester CHM and empty sacs, we observed a primitive network of mainly cords. CONCLUSIONS This first visualization of the spatio-temporal patterns of blood vessel formation in placental villi is characterized by the development of the vasculosyncytial membrane from a complex network of cords and can be regarded as the placental development before it becomes functional at the end of organogenesis.
ANew Perspective of Enterprise Human Resource Management

In the new century, the traditional model of enterprise human resource management is facing the challenge of the times, improving the human resource management of enterprises, and must innovate the concept of enterprise human resource management. After the 1950s, some economists established the theory of human capital, not only can more effectively explain the problems of modern social economic growth, but also on the enterprise's human resources management contribution to a positive impact. This paper introduces the concept of human capital and human capital investment into enterprise human resource management, which opens up a new perspective for enterprise human resource management. In this paper, we will first define the characteristics of human capital and the main body of human capital investment, and then analyze the meaning of various human resource management behaviors from the perspective of capital investment, estimate their benefits, costs and risks, and finally use scientific means to establish investment decision model and risk control mechanism, to maximize the effectiveness of human resources, so that the management behavior of enterprise's human can bring more revenue for the enterprises, thereby enhancing the competitiveness of enterprises. At present, the scientific operation of human resources is the key to the healthy development of enterprises.
The posttranslational modification of phosphoglucomutase is regulated by galactose induction and glucose repression in Saccharomyces cerevisiae

The enzyme phosphoglucomutase functions at a key point in carbohydrate metabolism. In this paper, we show that the synthesis of the major isoform of yeast phosphoglucomutase, encoded by the GAL5 (PGM2) gene, is regulated in a manner that is distinct from that previously described for other enzymes involved in galactose metabolism in the yeast Saccharomyces cerevisiae. Accumulation of this isoform increased four- to sixfold when the culture experienced either glucose depletion or heat shock. However, heat shock induction did not occur unless the cells were under glucose repression. This nonadditive increase in expression suggests that the regulatory mechanisms controlling the heat shock induction and glucose repression of the GAL5 gene are functionally related. We previously demonstrated that phosphoglucomutase is modified by a posttranslational Glc-phosphorylation reaction. We now show that this posttranslational modification, like phosphoglucomutase expression itself, is also regulated by galactose induction and glucose repression. Finally, no evidence was found to indicate that the Glc-phosphorylation of phosphoglucomutase alters its enzymatic activity under the conditions examined.
Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity.

Factor D is a serine protease essential for the activation of the alternative pathway of complement. The structures of native factor D and a complex formed with isatoic anhydride inhibitor were determined at resolution of 2.3 and 1.5 A, respectively, in an isomorphous monoclinic crystal form containing one molecule per asymmetric unit. The native structure was compared with structures determined previously in a triclinic cell containing two molecules with different active site conformations. The current structure shows greater similarity with molecule B in the triclinic cell, suggesting that this may be the dominant factor D conformation in solution. The major conformational differences with molecule A in the triclinic cell are located in four regions, three of which are close to the active site and include some of the residues shown to be critical for factor D catalytic activity. The conformational flexibility associated with these regions is proposed to provide a structural basis for the previously proposed substrate-induced reversible conformational changes in factor D. The high-resolution structure of the factor D/isatoic anhydride complex reveals the binding mode of the mechanism-based inhibitor. The higher specificity towards factor D over trypsin and thrombin is based on hydrophobic interactions between the inhibitor benzyl ring and the aliphatic side-chain of Arg218 that is salt bridged with Asp189 at the bottom of the primary specificity (S1) pocket. Comparison of factor D structural variants with other serine protease structures revealed the presence of a unique "self-inhibitory loop". This loop (214-218) dictates the resting-state conformation of factor D by (1) preventing His57 from adopting active tautomer conformation, (2) preventing the P1 to P3 residues of the substrate from forming anti-parallel beta-sheets with the non-specific substrate binding loop, and (3) blocking the accessibility of Asp189 to the positive1y charged P1 residue of the substrate. The conformational switch from resting-state to active-state can only be induced by the single macromolecular substrate, C3b-bound factor B. This self-inhibitory mechanism is highly correlated with the unique functional properties of factor D, which include high specificity toward factor B, low esterolytic activity toward synthetic substrates, and absence of regulation by zymogen and serpin-like or other natural inhibitors in blood.
Forebrain mapping of secretoneurin‐like immunoreactivity and its colocalization with isotocin in the preoptic nucleus and pituitary gland of goldfish

Secretoneurin, a 33–34 amino acid neuropeptide derived from the proteolytic processing of the secretogranin‐II precursor protein, is reasonably well conserved in evolution. Goldfish secretoneurin shares >75% similarity overall with other vertebrate secretoneurin sequences. The secretoneurin peptide has numerous functions that include neuroinflammation, neurotransmitter release, and neuroendocrine regulation. A detailed description of the central distribution of secretoneurin immunoreactivity is only known for the rat. Using our polyclonal antibody against the central, conserved core of the secretoneurin peptide we studied the distribution of secretoneurin‐like immunoreactivity in the goldfish brain. Secretoneurin immunoreactivity was found in the olfactory bulb, entopeduncular nucleus, preoptic nucleus, lateral part of the lateral tuberal nucleus, posterior periventricular nucleus, nucleus of the posterior recess, the nucleus of the saccus vasculosus, and nucleus isthmi. Secretoneurin‐immunoreactive fibers were found in the dorsal part of the dorsal telencephalon, ventral and lateral parts of the ventral telencephalon, periventricular preoptic nucleus, pituitary, and the ventrocaudal aspect of the nucleus of the lateral recess. The most conspicuous secretoneurin immunoreactivity was found in the magnocellular and parvocellular cells of the preoptic nucleus that project to the pituitary. Double‐labeling studies indicated coexpression with isotocin, the fish homolog of mammalian oxytocin. Clear colabeling for secretoneurin and isotocin in fibers terminating in the neurointermediate lobe suggests that secretoneurin maybe coreleased with isotocin. Previous work indicates that secretoneurin stimulates the release of luteinizing hormone from the goldfish anterior pituitary. Our findings further support a reproductive role for secretoneurin and related peptides, given the importance of oxytocin family peptides in reproductive behavior in vertebrates. J. Comp. Neurol. 519:3748‐3765, 2011. © 2011 Wiley‐Liss, Inc.
Determinants of heterosexual relationships and sexual behaviours among elite young females in Tehran , Iran .

Background: This paper is based on a mixed method study conducted in 2005-6 aiming to investigate sexual conduct of female college students in Tehran. An objective was to assess social and individual factors responsible for variation in premarital heterosexual relationships and sex. Method: This paper focuses on the survey conducted on a sample of 1743 female undergraduate students in four multidisciplinary universities in Tehran using a twostage stratified cluster sampling. Main focus was to determine the predictors of premarital friendships and sexual intercourse among unmarried females. Results: Nearly half of unmarried women(n=1400, mean age: 21.4) reported friendships with men, more than one-fifth reported any type of sex (23%)and one-tenth reported sexual intercourse. A model including strict parental control (OR=0.70), watching pornography (OR=1.37), low self-efficacy (OR=0.75), liberal personal attitudes (OR=1.14), peers’ involvement in premarital relationships (OR=1.49) and perceived societal norms (OR=1.09) could predict more than 50% of chances to have premarital intercourse. Conclusion: Interventional programs need to be designed at various level such as enhancing self-efficacy, informing families of the protective role of a balanced control and monitoring over adolescents' behaviors and choices of peer network" against premarital sexual activity. 1 Research fellow, Family Research Institute, Shahid Beheshti University, G.C. Correspondent author, e-mail : faridehfarahani@yahoo.com 2 Professor in Medical Demography, Centre for Population Studies, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine 3 Professor in Psychiatry, Director, Center for Population Studies & Researches