Miracle-dz/UniFAR-FTUs huggingface dataset:
A systematic review of clinical outcomes, clinical process, healthcare utilization and costs associated with telerehabilitation

Purpose. To identify clinical outcomes, clinical process, healthcare utilization and costs associated with telerehabilitation for individuals with physical disabilities. Method. Relevant databases were searched for articles on telerehabilitation published until February 2007. Reference lists were examined and key journals were hand searched. Studies that included telerehabilitation for individuals with physical impairments and used experimental or observational study designs were included in the analysis, regardless of the specific clientele or location of services. Data was extracted using a form to record methodological aspects and results relating to clinical, process, healthcare utilization and cost outcomes. Study quality of randomized clinical trials was assessed using the PEDro rating scale. Results. Some 28 articles were analysed. These dealt with rehabilitation of individuals in the community, neurological rehabilitation, cardiac rehabilitation, follow-up of individuals with spinal cord injuries, rehabilitation for speech-language impairments, and rehabilitation for varied clienteles. Clinical outcomes were generally improved following a telerehabilitation intervention and were at least similar to or better than an alternative intervention. Clinical process outcomes, such as attendance and compliance, were high with telerehabilitation although few comparisons are made to alternative interventions. Consultation time tended to be longer with telerehabilitation. Satisfaction with telerehabilitation was consistently high, although it was higher for patients than therapists. Few studies examined healthcare utilization measures and those that did reported mixed findings with respect to adverse events, use of emergency rooms and doctor visits. Only five of the studies examined costs. There is some preliminary evidence of potential cost savings for the healthcare facility. Conclusions. While evidence is mounting concerning the efficacy and effectiveness of telerehabilitation, high-quality evidence regarding impact on resource allocation and costs is still needed to support clinical and policy decision-making.
Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer

It has not been well established whether genetic variations can be biomarkers for clinical outcome of gemcitabine therapy. The purpose of this study was to identify single nucleotide polymorphisms (SNPs) of gemcitabine metabolic and transporter genes that are associated with toxicity and efficacy of gemcitabine‐based therapy in patients with locally advanced pancreatic cancer.
The difference a word makes: responding to questions on ‘disability’ and ‘difficulty’ in South Africa

Purpose. This article discusses the current efforts to measure disability in a comparable manner internationally, the effects of using different types of wording in questions, and the implications of the approach of asking about ‘difficulties’ rather than ‘disability’ on the use of disability statistics. Method. The study design was qualitative. Twenty-one focus groups were run with adults responding for themselves. Nine groups were classified a priori by the author as ‘disabled’, six as ‘unsure’, and the last six as ‘non-disabled’. The participants completed a questionnaire using the Washington Group on Disability Statistics (WG) Short Set, the South African Census 2001 question, and the question ‘Are you disabled? ’. This was followed by group discussion on these questions and on how the concept of disability is understood by group participants. Results. Participants understand disability as being a permanent, unchangeable state, mostly physical, and where a person is unable to do anything. The participants in the three groups of allocated disability status (disabled, unsure and non-disabled) provided quite different responses on the three questions. All participants in the ‘disabled’ and ‘unsure’ groups reported having ‘difficulty’ on the WG questions, but the ‘unsure’ groups did not identify as being ‘disabled’ on either of the two other questions. Conclusions. Using questions that ask about ‘difficulty’ rather than ‘disability’ provides a more comprehensive and inclusive measure of disability with a clearer understanding of what is being measured. Asking about ‘difficulty’ provides an improved measure of disability status for effective data collection and analysis to promote development, implementation and monitoring of disability-inclusive policies.
Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty in Stromal Keratitis Caused by an Endoreticulatus-like Microsporidia

Purpose: To describe a case of stromal keratitis caused by an Endoreticulatus-like microsporidia satisfactorily treated with femtosecond-assisted anterior lamellar keratoplasty (femto-ALK). Methods: Case report. Results: A 65-year-old healthy woman had a 10-month history of foreign body sensation and blurred vision after a flying insect struck her right eye. The patient presented with focal central to paracentral anterior stromal infiltration and edema with keratic precipitates of the right cornea. Confocal microscopy showed enhanced keratocytes with intracellular hyperreflective round and ovoid bodies confined to the anterior two thirds of corneal stroma. Femto-ALK was performed for excisional biopsy and replacement with anterior stromal donor cornea. A modified trichrome stain of corneal tissue showed numerous microsporidial spores whose small subunit rRNA sequence belonged to that of an Endoreticulatus-like microsporidia. Conclusions: Besides systemic infection, Endoreticulatus-like microsporidia can cause stromal keratitis. With careful patient selection, femto-ALK may be considered a new surgical alternative with satisfactory treatment outcomes.
Subungual pyogenic granuloma treated by sodium tetradecyl sulfate sclerotherapy.

Pyogenic granuloma is a relatively common, acquired hemangioma, composed of welldifferentiated vessels. These lesions grow rapidly and are usually found on the head and neck region of the body. A minor injury is often described as an etiologic factor. Many treatment options are available. Sometimes it is unclear which treatment approach to use; this is especially the case for lesions in the subungual location. Herein a case with subungual pyogenic granuloma treated by sodium tetradecyl sulfate sclerotherapy is described.
Relationship between current level of immunodeficiency and non‐acquired immunodeficiency syndrome‐defining malignancies

In the combined antiretroviral therapy (cART) era, non–acquired immunodeficiency syndrome (AIDS)‐defining malignancies account for more morbidity and mortality in human immunodeficiency virus‐infected patients than AIDS‐defining malignancies. However, conflicting data have been reported on the relationship between immunodeficiency and the development of some non–AIDS‐defining malignancies.
Nonsurgical Rhinoplasty: An Evaluation of Injectable Calcium Hydroxylapatite Filler for Nasal Contouring

For decades, surgical rhinoplasty has been the therapeutic gold standard for individuals seeking to improve the cosmetic appearance of their nose. The technique, however, is not without its drawbacks. In many cases, postoperative edema and ecchymoses have resulted in prolonged downtimes as well as significant delays in achieving desired cosmetic outcomes. Furthermore, the need to raise an alar flap can result in scarring in the alar crease, particularly among patients with a hereditary predisposition toward hypertrophic scars/keloids. Finally, as with any surgical procedure, rhinoplasty has been associated with intrinsic perioperative complications, including reactions to anesthesia, infection, bleeding, and in rare instances, death.
Quality of life in MS: Does aging enhance perceptions of mental health?

Purpose. This study was designed to examine the relationship between age and quality of life in middle aged and older adults with MS. Method. Individuals with MS, recruited through a Comprehensive Care Centre and local registries of the National Multiple Sclerosis Society, completed a telephone interview which incorporated several scales of the MS Quality of Life Inventory. Participants were divided into three age groups reflective of developmental transitions in adulthood, from midlife transition to late adulthood. Results. Between group comparisons controlling for physical functioning and duration of MS revealed that the oldest age group (age 65 and above) reported significantly better mental health than the middle age group (age 50–64), but not the youngest age group (age 35–49). Differences between the middle and youngest age group were not significant. Conclusions. Results suggest that perhaps the process of getting older, or factors related to being older, enhance perceptions of mental health in individuals with MS. Results are discussed within the context of social comparison theory, which might be an adaptive strategy that could underlie response shift in older individuals with MS.
A review of participation instruments based on the International Classification of Functioning, Disability and Health

Purpose. To identify and review instruments which assess participation as defined by the International Classification of Functioning, Disability and Health (ICF). Methods. A systematic search of the literature was conducted. Data related to the content, administration, scoring, reliability, validity and responsiveness was abstracted. Results. Eleven instruments met the inclusion criteria. Seven instruments include questions with content from Chapters 4 to 9 in the ICF activities and participation component. Four instruments exclude Chapter 5 (self-care). Most of the instruments assess subjective aspects of participation. Evidence on reliability was available for 10 instruments and the majority met the criteria for group level comparisons for internal consistency and reproducibility in the health conditions assessed. In terms of validity, dimensionality was assessed in eight instruments, with six using modern measurement methods. Participation instruments have been compared with various generic and/or disease-specific instruments, but they have not been compared with each other. Evidence on responsiveness was only available for four instruments. Conclusions. There has been considerable interest in developing instruments to measure participation. To date, the World Health Organisation Disability Assessment Schedule II has undergone the most psychometric testing. Future research must continue to assess these instruments in persons with various health conditions to advance the conceptualisation and measurement of participation.
Quel bilan d’extension faut-il faire pour les carcinomes indifferencies du nasopharynx ?

Introduction : Nasopharyngeal carcinoma prognosis is often correlated with its local extension but especially lymphatic node and metastatic. The aimof our work was to study sensitivity and the specificity of clinical and paraclinic explorations in the initial assessment Patients and methods : It . s about a retrospective study of 366 patients having nasopharyngeal carcinoma, diagnosed over eleven years period between 1993 and 2003 in Sfax hospital. Into pretherapeutic, all the patients had a complementary assessment including:- Nasopharyngeal tomodensitometry (TDM), in all the cases, extended to the cervical area in 112 cases and a magnetic resonnance Imagery (MRI) of the nasopharynx and cerebral in 18 cases. - Metastatic assessment : comprising systematically a chest radiography, an abdominal ultrasonography and an osseous scintiscanning. The statistical study comprised a descriptive study and an analytical study. Results : The metastasis diagnosis was retained in 39 cases (10,7%): osseous in 82%, hepatic in 23% and pulmonary in 12,8% of the cases. The tumour was associated to lymph node N3 in 25 cases (64%). At univariate study, we retained the presence of significant difference between the groups of the metastatic and lack metastatic patients for : the male sex, reason for consultation (cervical node, rhinologic signs and otologic signs) and cervical node at the examination. The multivariate analysis for all the factors was without interest. We choose the parameters according to the result of the univariate study, the literature and parameters' found among all patients with discovered CNP. It comes out from this study that the following elements are providers of metastases: age between 40 and 45years, male sex and cervical node N3a stage. Discussion : The assessment of extension is not standardized for all the authors. Indeed, for the study of the pulmonary extension (AJCC)/ (UICC) recommends the systematic practice of the chest radiography. For (NCCN), the practice of chest radiography is only for patients classified at the stage 2 and 3 in WHO classification. For KUMAR, LEUNG and our results, it is recommended systematically to practice the chest radiography . This radiography would be supplemented by a thoracic tomodensitometry with the least suspect lesion. For the hepatic assessment, some recommend the systematic practice of abdominal echography for the advanced node stages (N3). For others, it will be indicated only for the symptomatic patients. For (AJCC)/ (UICC) abdominal echography is systematic. For the osseous assessment, KRAIPHIBUL recommends the practice of the osseous scintiscanning only for patients having signs of osseous call but LEUNG and SHAM recommend the practice of the osseous scintiscanning only for the patients having cervical node N3. Key words: Nasopharyngeal carcinoma/ extension assessment/ metastasis.
Prevalence and impact of disability and sexual dysfunction on Health-Related Quality of Life of Nigerian stroke survivors

Abstract Purpose: To investigate the impact of disability and sexual dysfunction on Health-Related Quality of Life (HRQoL) among Nigerian stroke survivors (SSv) and to determine their association using sexual functioning (SF), Global Disability Measure and Function (GDMF), and demographic profiles. Methods: This study involved 121 consecutive SSv attending healthcare services in two tertiary health facilities in Nigeria. Demographic details were obtained through interview while HRQoL, SF, and Global Disability (GD) were assessed using Stroke-Specific Quality of Life (SS-QoL-12), Changes in Sexual Functioning Questionnaire (CSFQ-14), and World Health Organization Disability Assessment Schedule (WHODAS-2.0), respectively. Determinants of HRQoL were explored using the Poisson regression analysis. Results: Most of the SSv had moderate/severe GD (95%) and low SF (86.8%). Their HRQoL decreased with increase in their age (p = 0.005) and with increase in GD (p = 0.001). This association remained unchanged even when adjusted for SF (p = 0.001). Those with low SF but with mild GD had relatively better HRQoL than those with moderate/severe GD even when they had higher SF. Their HRQoL was negatively impacted by their GD but not by their SF despite direct correlation between SF and HRQoL. With a unit increase in level of GD, there was 8% decrease in HRQoL scores in psychosocial and 17% decrease in physical domains. Conclusion: Although sexual dysfunction and global disability are prevalent among Nigerian SSv, their low HRQoL is determined by their disability and not by SF. Hence, effort at reducing global disability should be the focus of rehabilitation after stroke. Implication for Rehabilitation Global functional and sexual deficiencies abound in stroke survivors and they impact negatively on their overall quality of life. Sexual dysfunction correlates negatively on physical and psychosocial wellbeing of stroke survivors. Rehabilitation goal(s) should focus disability reduction and improvement of sexual functioning to enhance quality of life. Rehabilitation professionals should equip themselves with tools to counsel stroke survivors on sex issue since sexual dysfunction is common post stroke.
Mapping the rehabilitation interventions of a community stroke team to the extended International Classification of Functioning, Disability and Health Core Set for Stroke

Abstract Purpose: This study aim was to evaluate whether the Extended International Classification of Functioning, Disability and Health Core Set for Stroke captured the interventions of a community stroke rehabilitation team situated in a large city in New Zealand. It was proposed that the results would identify the contribution of each discipline, and the gaps and differences in service provision to Māori and non-Māori. Applying the Extended International Classification of Functioning, Disability and Health Core Set for Stroke in this way would also inform whether this core set should be adopted in New Zealand. Method: Interventions were retrospectively extracted from 18 medical records and linked to the International Classification of Functioning, Disability and Health and the Extended International Classification of Functioning, Disability and Health Core Set for Stroke. The frequencies of linked interventions and the health discipline providing the intervention were calculated. Results: Analysis revealed that 98.8% of interventions provided by the rehabilitation team could be linked to the Extended International Classification of Functioning, Disability and Health Core Set for Stroke, with more interventions for body function and structure than for activities and participation; no interventions for emotional concerns; and limited interventions for community, social and civic life. Results support previous recommendations for additions to the EICSS. Conclusions: The results support the use of the Extended International Classification of Functioning, Disability and Health Core Set for Stroke in New Zealand and demonstrates its use as a quality assurance tool that can evaluate the scope and practice of a rehabilitation service. Implications for Rehabilitation The Extended International Classification of Functioning Disability and Health Core Set for Stroke appears to represent the stroke interventions of a community stroke rehabilitation team in New Zealand. As a result, researchers and clinicians may have increased confidence to use this core set in research and clinical practice. The Extended International Classification of Functioning Disability and Health Core Set for Stroke can be used as a quality assurance tool to establish whether a community stroke rehabilitation team is meeting the functional needs of its stroke population.
Patients with only 1 positive hormone receptor have increased locoregional recurrence compared with patients with estrogen receptor‐positive progesterone receptor‐positive disease in very early stage breast cancer

Estrogen receptor (ER) and progesterone receptor (PR) are important prognostic and predictive biomarkers in breast cancer. Patients with tumors positive for either receptor are generally considered hormone receptor‐positive for treatment decisions. However, some data suggest that patients with ER+/PR− or ER−/PR+ tumors may have worse outcomes than those with ER+/PR+ tumors. Few data correlate these biomarkers with locoregional (LR) recurrence.
Die Berufsdermatosen der Arbeiter

Von Dr. A. Blasehko in Berlin. I. Das Galvaniseur-Ekzem. Ich beabsichtige in folgendem eine Reihe von Hautaffectionen zu schildern, welche in den verschiedenen Gewerben als Begleitund Folgeerscheinungen der Berufsthätigkeit und der mit derselben verbundenen schädlichen Momente auftreten, Affectionen, welche zum Theil den Dermatologen schon seit langer Zeit wohl bekannt sind, zum andern Theil jedoch entsprechend den immer neuen Gebieten, welche der werkthätigen Industrie alljährlich erschlossen werden bisher noch weniger genau studirt worden sind. Zu der letztgenannten Gruppe gehört eine Form des Ekzems, welche ich im Laufe der letzten Jahre mit zunehmender Häufigkeit bei einer ganz bestimmten Classe gewerblicher Arbeiter den Galvaniseuren beobachtet habe, und auf welche meines Wissens noch von keiner Seite aufmerksam gemacht worden ist. Das Ekzem findet sich bei denjenigen in Metallwaarenfabriken beschäftigten Arbeitern, welchen das Galvanisiren, d. i. die durch den galvanischen Strom erzeugte Bedeckung metallischer Gegenstände mit einer Schicht eines anderen Metalles oder Metallgemisches überantwortet ist, eine Thätigkeit, welche jetzt von männlichen und weiblichen Arbeitskräften ausgeübt wird. Das grösste Contingent zu den Erkrankungsfällen stellen die Gürtler, Goldarbeiter, sowie die in der Bijouterieund Galanteriewaarenfabrikation in galvanoplastischen Instituten beschäftigten Arbeiter, die chirurgischen Instrumentenmacher ferner, u. a. m. Man findet bei diesen Kranken ein subacut oder chronisch verlaufendes Ekzem, das zunächst und in einer Reihe von Fällen ausschliesslich die Dorsalfiäche der Finger und Hände, das Handgelenk und manchmal die Ellbeugen ergreift. In einzelnen Fällen verbreitet sich das chronisch bestehende Ekzem acut über den ganzen Körper und befällt dann zunächst die nicht bedeckten Theile: Gesicht, Ohren, Hals und Nacken. Die Erkrankung beginnt zumeist mit dem Auftreten einer oder mehrerer meist ziemlich scharf umschriebener Stellen, an denen die Haut aufgesprungen, die Oberhaut verdickt, rauh und brüchig, von punktförmigen und lineären leicht blutenden Rhagaden durchsetzt ist. Prädileetionsstellen für diese erste Erkrankungsform sind die dritten Phalangen der drei Mittelfinger, die Interdigitalfalten und die Radialkante des Handgelenks. In einigen Fällen entwickeln sich aus diesen ursprünglichen Herden grössere confluirende Flächen von vesiculösem, pustulösem und impetiginösem Ekzem, es schiessen zahlreiche neue, vereinzelt und gruppirtstehende Bläschen zwischen den alten Herden auf, und ein grosser Theil des Handrückens, sowie die angrenzenden Theile des Vorderarms werden. ergriffen. Aber dieser Verlauf ist selten. In der Regel bestehen die anfänglichen Herde entweder lange Zeit hinDEUTSCHE MEDICINISCRE WOCHENSOHRIFT 925
The impact of tumor burden characteristics in patients with metastatic renal cell carcinoma treated with sunitinib

An important goal of noncurative therapy for metastatic renal cell carcinoma (mRCC) is tumor burden (TB) control. However, to the authors' knowledge, the impact of TB characteristics on clinical outcome has not been studied in patients with mRCC who were treated with vascular endothelial growth factor‐targeted therapy.