Miracle-dz/UniFAR-FTUs huggingface dataset:
The Plasmodium falciparum clag9 gene encodes a rhoptry protein that is transferred to the host erythrocyte upon invasion

The first gene characterizing the clag (cytoadherence linked asexual gene) family of Plasmodium falciparum was identified on chromosome 9. The protein product (Clag9) was implicated in cytoadhesion, the binding of infected erythrocytes to host endothelial cells, but little information on the biochemical characteristics of this protein is available. Other genes related to clag9 have been identified on different chromosomes. These genes encode similar amino acid sequences, but clag9 shows least conservation. Clag9 was detected in schizonts, merozoites and ring‐stage parasites after protease digestion and peptide analysis by mass spectrometry. Using antisera raised against unique regions of Clag9 and against RhopH2, a component of the RhopH high‐molecular‐mass protein complex of merozoites, immunofluorescence co‐localized the two proteins to the apical region of merozoites. Immunoelectron microscopy co‐localized Clag9 and RhopH2 exclusively to the basal bulb region of rhoptries rather than to their apical ducts. The same Clag9‐specific antibodies bound the RhopH complex, and the protein was detected in the complex purified by antibodies to RhopH2. Clag9 protein was also shown to be present in ring‐stage parasites, carried through from the previous cycle with the RhopH complex, in a location identical to that of RhopH2. Transcription of the clag9 gene was shown to occur at the same time as the genes for other members of the RhopH complex, rhoph2 and 3. The results indicate that Clag9 is part of the RhopH complex and suggest that, within this complex, the protein previously designated RhopH1 is composed of more than one protein product of the clag gene family. The results cast doubt on a direct role for Clag9 in cytoadhesion; we suggest that the primary role of the RhopH complex is in remodelling the infected red blood cell after invasion by the merozoite. The complex may have multiple functions dependent on its exact composition, which may include, with respect to Clag9, a contribution to the mechanism of cytoadhesion.
Corporate Facebook posts in the UK and Greece: a content analysis

Despite the proliferation of research on the value of Facebook as a marketing tool, there is limited understanding on how companies use Facebook to interact with consumers. At the same time, very little is known about consumers' response to corporate Facebook posts. The present study adopts a cross-cultural approach and investigates (a) the differences in the content of corporate Facebook posts between the UK and Greece with respect to the use of informational and emotional content, and (b) consumers' response to these posts. A content analysis of 2000 corporate Facebook posts reveals that message content is country specific. UK corporate Facebook posts focus on informational content, whereas Greek corporate Facebook posts emphasise emotional content. Our results also reveal differences in the behaviour of Facebook users in the two countries. In the UK, corporate Facebook posts with informational content collect more 'Likes' compared to posts with non-informational content, whereas corporate Facebook posts with emotional content attain more 'Likes' than non-emotional posts in Greece.
A Fatal Case of Super-super Obesity (BMI >80) in a Patient with a Necrotic Soft Tissue Infection

A 35-year-old man (height, 169 cm; body weight, 240 kg; BMI, 84) visited the Department of Dermatology due to left leg pain and swelling. Focused enhanced computed tomography (CT) of the left leg ruled out complications of deep venous thrombosis. Surgical exploration of the left leg resulted in a diagnosis of necrotic soft tissue infection, but amputation was ruled out due to his weight. The patient ultimately died of multiple organ failure on the fourth day of hospitalization. A culture of the surgical material revealed Streptococcus dysgalactiae. The present case suggests that super-obese patients should be aggressively treated before lethal complications occur.
Possible locally driven folding pathways of TC5b, a 20‐residue protein

A novel computational procedure for modeling possible locally driven folding pathways by stepwise elongations of the peptide chain was successfully applied to TC5b, a 20‐residue miniprotein. Systematic exploration of the possible locally driven pathways showed that the Trp‐cage structure of TC5b could be obtained by stepwise elongation starting from the noncentral local nucleation centers preexisting in the unfolded state of TC5b. The probable locally driven folding pathway starts with folding of α‐helical fragment 4‐9, followed by formation of the proper three‐dimensional structure of fragment 4‐12, and then 4‐18. Accordingly, the Trp‐cage‐forming interactions emerge successively, first Trp6–Pro12, then Trp6–Pro18, and then Trp6–Tyr3. The Trp‐cage‐like structures of TC5b found in this study by independent energy calculations are in excellent agreement with the NMR experimental data. The same procedure rationalizes the incomplete Trp‐cage formation observed for two analogs of TC5b. Generally, the success of this novel approach is encouraging and provides some justification for the use of computational simulations of locally driven protein folding. Proteins 2003;52:292–302. © 2003 Wiley‐Liss, Inc.
Photophosphorylation and oxidative phosphorylation in intact cells and chromatophores of an aerobic photosynthetic bacterium, Erythrobacter sp. strain OCh114

Light-induced ATP synthesis was studied in intact cells and chromatophores of Erythrobacter sp. strain OCh114. ATP synthesis was measured by both the pH method and the luciferin-luciferase luminescence method. The rate of ATP synthesis was moderate (a typical value of 0.65 mol of ATP per mol of bacteriochlorophyll per min), and synthesis was inhibited by antimycin A. ATP was synthesized under illumination only under aerobic conditions and not under anaerobic conditions. This characteristic was similar to that of other light-induced energy transduction processes in this bacterial species, such as oxidation of reaction center, oxidation of cytochrome c551, and translocation of H+, which were not observed under anaerobic conditions. This phenomenon was reconciled with the fact that the Erythrobacter sp. could not grow anaerobically even in the light. The characteristics of oxidative phosphorylation and ATP hydrolysis were also investigated. The respiratory ratio of chromatophores was 2.3. Typical rates of oxidative phosphorylation by NADH and by succinate were 2.9 mol of ATP per mol of bacteriochlorophyll per min (P/O = 0.22) and 1.1 mol of ATP per mol of bacteriochlorophyll per min (P/O = 0.19), respectively. A typical rate of ATP hydrolysis was 0.25 mol of ATP per mol of bacteriochlorophyll per min in chromatophores. ATPase and adenylate kinase are also involved in the metabolism of adenine nucleotides in this bacterium.
Cutaneous stigmata associated with insulin resistance and increased cardiovascular risk

Certain cutaneous conditions have been reported to be associated with diabetes mellitus, insulin resistance, and metabolic syndrome. In this novel review paper, the evidence linking various cutaneous phenomena (e.g. skin tags, acanthosis nigricans, ear lobe creases, and xanthelasma) and metabolic syndrome and cardiovascular disease is examined, and explanations for these associations are proposed.
Sustainability Reporting Practices: Evidence from Bangladesh

The objective of this paper is to examine the nature and extent of sustainability reporting practices by the listed companies in Bangladesh. In order to fulfill this objective, the research has examined the content analysis of annual report (2015-2016) and website of the top 50 listed companies (according to market capitalization). Based on Global Reporting Initiative (GRI) G4 guidelines, the study investigates three broad areas i.e. economic, environmental and social with 40 indicators. The findings of the study demonstrate that organizations in Bangladesh address few sustainability issues. Companies focus more on community development which is 90%, followed by employment and employee benefits (67%). The level of disclosures in website is meagre where only 26% of the sample companies disclose at least one indicator. Organizations’ attention on issues like environment, human rights and product responsibility is limited in relation to other issues. The extent of disclosure is also poor that is 66% of the companies use less than 25 sentences in sustainability reporting. Moreover, only 16% of the sample companies use separate sustainability reporting section. The limited disclosures on sustainability issues may be because of voluntary sustainability reporting in Bangladesh.
Impact of Shrimp Imports on the United States' Southeastern Shrimp Processing Industry and Processed Shrimp Market.

The shrimp harvesting sector is the largest component o f the southeastern United States fishing industry, accounting for 57% of the total value o f landings in the region in 1996. U.S. shrimp imports were valued at $2.6 billion in 1996. Together, domestic production and imports o f the raw product support a large shrimp processing sector, which provides several thousand jobs either direcdy or indirecdy. In 1975 and 1984, the United States International Trade Commission (USITC) investigated the industry to determine whether the volume of shrimp imports was high enough to threaten domestic firms which were producing articles similar to, or direcdy competitive with the imported product. In both studies, the commission concluded that no harm was done to the processing sector. However, an analysis o f the shrimp industry that focused on the processing sector revealed that imports did have a negative impact. The objectives of this research were to quantify the effects o f imported shrimp quantities on processor margins and firm size distribution. Results showed that retail prices of shrimp negatively affected per capita shrimp consumption. Red meat and fish products were found to be shrimp substitutes. A t the wholesale level, findings support a peeled shrimp sector dominated by imports. The import effects increased after 1983 due to the development o f shrimp farming in South Asia and Latin America. Additionally, imports o f headless-shell-on and “other” shrimp products have negatively impacted the domestic processing activities. The ex-vessel demand was responsive to changing domestic landings and imported headlessshell-on shrimp quantities. Wholesalers were not passing on increased production costs to consumers. Consequently the margins for processors of peeled shrimp and headlessshell-on shrimp narrowed annually by $0.0323 and $0.0407 per pound. The narrowing in the margins impacted the processor size distribution. In 1973, out of 181 active processors, 45% had total shrimp sales below $1 million a year, 38% between $1 and $10 million, and 21% above $10 million. By 1996, those percentages were 38%, 36% and 32% for categories 1, 2 and 3 with a total o f 97 firms processing shrimp.
Stock Market Activities and Industrial Production Growth: Evidence from 20 International Markets

Abstract This study presents evidence on the relations of stock market performance and industrial production growth for a group of 20 industrial markets. Evidence supports the notion that an increase in stock returns or a rise in the market value of stocks contributes positively to industrial production growth. Evidence suggests that stock market risk has a significantly negative effect on production growth for advanced markets. The Granger test finds a unidirectional causality running from stock returns or stock volatility to industrial growth. However, the United States shows a bilateral causality between stock volatility and industrial production growth.
The ModelTalker Project: A Web-Based Voice Banking Pipeline for ALS/MND Patients

The Nemours ModelTalker supports voice banking for users diagnosed with ALS/MND and related neurodegenerative diseases. Users record up to 1600 sentences from which a synthetic voice is constructed. For the past two years we have focused on extending and refining a web-based recording tool to support this process. In this demonstration, we illustrate the features of the web-based pipeline that guides patients through the process of setting up to record at home, recording a standard speech inventory, adding custom recordings, and screening alternative versions of their voice and alternative synthesis parameter settings. Finally, we summarize results from 352 individuals with a wide range of speaking ability, who have recently used this voice banking pipeline.
Portfolio Management: The Process and its Dynamics

Like many areas of business, portfolio management is both an art and a science. It is much more than the selection of securities from a catalog by a financial consultant or the application of a formula to a set of financial data input supplied by a security analyst. It is a dynamic decision-making process, one that is continuous any systematic but also one that requires large amounts of astute managerial judgment about the securities markets and the individual for whom portfolio is managed. The author in this article documents the processes involved in portfolio management and the considerations which are of paramount importance in constructing an individual’s portfolio.
Discrepancies between Premorbid and Current IQ as a Function of Progressive Mental Deterioration

The declining cognitive functioning typically found in patients with Alzheimer's disease presents an opportunity to study that decline. The changing magnitude of ever widening discrepancies between premorbid estimators of IQ and observed IQ increases as severity of the disease increases. Premorbid IQs estimated by these scores (the National Adult Reading Test–Revised, the reading tests of the Revised and Third Editions of the Wide Range Achievement Test, and a demographically based regression index for the Wechsler Adult Intelligence Scale–Revised) had relatively similar discrepancies from obtained WAIS–R Full Scale IQs in samples of normal elderly (n = 30), and elderly patients diagnosed with mild (n = 30) and moderate Alzheimer's disease (n = 30) dementia. The discrepancies became larger, regardless of premorbid estimator, as disease severity progressed from none to mild to moderate across the samples.
Some of immunogenetic status of HBsAg negative, HBcAb positive Blood donors in Basra province-Iraq

Occult HBV infection is characterized as a clinical form of hepatitis B in which, despite the absence of detectable HBsAg in the serum of patients, HBV-DNA is present in the serum or liver. In this study we aimed to selecting of HBsAg negative, HBcAb positive patients among plasma samples of healthy blood donors and evaluate some of the elements of humoral immunity. The results from this study showed that all examined 350 Blood donors were divided by ELISA screening tests into four studied groups, HBsAg−/anti-HBc+ 65(18.58%) and Recovery 85(24.28%), 100 (28.57%) patients and 100 (28.57%) healthy. Our results showed that the serum levels of IgG and C3 were significantly higher in patients, while IgM and C4 were not significant among the studied groups. Based on these results, it could be concluded that one possible reason that HBV was able to persist in patients in HBsAg−/antiHBc+ group was their inability to produce appropriate levels of IgG antibodies directed towards the clearance of the viral infection.
Aortic coarctation in the adult: management of complications and coexisting arterial abnormalities with hypothermic cardiopulmonary bypass and circulatory arrest.

OBJECTIVES Adult patients with aortic coarctation may have complications after childhood repair. Other adult patients have coarctation and aneurysms of the aorta and the left subclavian artery. The optimal management of such cases is not clearly established. We evaluated the role of hypothermic cardiopulmonary bypass and circulatory arrest. METHODS Thirteen adult patients (mean age 38 years) with coarctation and coexisting abnormalities of the aorta and left subclavian artery were treated. Five patients had pseudoaneurysms develop after bypass grafting (n = 3) or patch angioplasty (n = 2). These were detected a mean of 21 years (range 13-44 years) after the initial operation. Four pseudoaneurysms were asymptomatic, and 1 had ruptured. One patient had recurrent coarctation from fibrous obliteration of a 10-mm bypass graft inserted 15 years previously. The remaining 7 patients had aneurysms of the left subclavian artery (n = 5), aneurysms of the ascending aorta and arch (n = 1), or stenosis of the left subclavian artery (n = 1) in combination with moderate or severe coarctation. Resection and interposition graft replacement of the aneurysmal or stenotic aortic segments were performed in all cases with an interval of hypothermic circulatory arrest that averaged 44 +/- 5 minutes (range 33-54 minutes). Seven patients had interposition graft replacement of aneurysmal or stenotic left subclavian arteries. RESULTS There were no in-hospital or late deaths (maximal follow-up 7 years). No patient had brain injury, paralysis, myocardial, respiratory, or renal failure. No patient has evidence of recurrent coarctation or aneurysm formation. CONCLUSIONS Cardiopulmonary bypass with hypothermic circulatory arrest can safely be used in the treatment of complex adult coarctation. It permits accurate delineation of the anatomy with minimal dissection, avoidance of aortic clamping and sacrifice of intercostal arteries, precise interposition graft repair, and adequate protection of vital organs.
Use of Antihypertensive and Antithrombotic Medications after Stroke in Community-Based Care

BACKGROUND: Secondary stroke prevention strategies include pharmacologic approaches to control hypertension and reduce thromboembolic risk. OBJECTIVE: To describe antithrombotic and antihypertensive medication use, and rates of blood pressure control in the Kansas City Stroke Study, a prospective stroke cohort receiving community-based care after primarily mild and moderate stroke. METHODS: Participants from 12 area hospitals provided information about medication use prior to stroke. Study personnel measured blood pressures at enrollment and at one, three, and six months, and collected medication data at six months during in-home assessment. RESULTS: Complete data at six months were available for 355 subjects with ischemic stroke, among whom 13% had atrial fibrillation and 67% had prior hypertension. Prior to stroke, only 45% of the patients were receiving any antithrombotic (anticoagulant and/or antiplatelet) therapy; this figure rose to 77% at six months. Antithrombotic treatment rates among those with atrial fibrillation were 59% before stroke and 83% at six months, including warfarin in 64%. Approximately 70% of subjects had controlled blood pressures one, three, and six months after stroke, defined as systolic blood pressure ≤140 mm Hg and diastolic blood pressure ≤90 mm Hg. Use of multiple antihypertensive agents was common; calcium-channel blockers and angiotensin-converting enzyme inhibitors were used most frequently. However, 19% of subjects with uncontrolled blood pressure were untreated at six months. CONCLUSIONS: Although room for improvement remains, these data suggest improved rates of antithrombotic and antihypertensive medication use after stroke in community-based care in a midwestern metropolitan community, compared with previous reports.
Statistical and judgmental criteria for scale purification

Purpose “Scale purification” – the process of eliminating items from multi-item scales – is widespread in empirical research, but studies that critically examine the implications of this process are scarce. The goals of this research are threefold: (1) to discuss the methodological underpinning of scale purification, (2) to critically analyze the current state of scale purification in supply chain management (SCM) research, and (3) to provide suggestions for advancing the scale purification process. Design/methodology/approach A framework for making scale purification decisions is developed and used to analyze and critically reflect on the application of scale purification in leading SCM journals. Findings This research highlights the need for rigorous scale purification decisions based on both statistical and judgmental criteria. By applying the proposed framework to the SCM discipline, a lack of methodological rigor and coherence is identified when it comes to current purification practices in empirical.
Novel mutations of the RPGR gene in RP3 families

X‐linked retinitis pigmentosa is a severe retinal degeneration characterized by night blindness and visual field constriction, leading to complete blindness within the third decade of life. Mutations in the RPGR gene (retinitis pigmentosa GTPase regulator), located on Xp21.1 in the RP3 region, have been associated with an RP phenotype. Further to our previous mutation screening of RPGR in families segregating with the RP3 locus, we have expanded this study to include other 8 RP3 pedigrees. Here we report the results of this expanded study and the identification of five mutations in RPGR, four of which are novel (IVS6+5 G>A, 950‐951delAA, 963 T>C, EX8del) and one of which occurs in the donor splice site of intron 1 (IVS1+1 G>A). These findings bring the proportion of “RP3 genotypes” with a mutation in this gene to 27% (10/37). Hum Mutat 15:386, 2000. © 2000 Wiley‐Liss, Inc.
Sports nutrition knowledge among collegiate athletes, coaches, athletic trainers, and strength and conditioning specialists.

CONTEXT Coaches, athletic trainers (ATs), strength and conditioning specialists (SCSs), and registered dietitians are common nutrition resources for athletes, but coaches, ATs, and SCSs might offer only limited nutrition information. Little research exists about sports nutrition knowledge and current available resources for nutrition information for athletes, coaches, ATs, and SCSs. OBJECTIVE To identify resources of nutrition information that athletes, coaches, ATs, and SCSs use; to examine nutrition knowledge among athletes, coaches, ATs, and SCSs; and to determine confidence levels in the correctness of nutrition knowledge questions within all groups. DESIGN Cross-sectional study. SETTING National Collegiate Athletic Association Division I, II, and III institutions across the United States. PATIENTS AND OTHER PARTICIPANTS The 579 participants consisted of athletes (n = 185), coaches (n = 131), ATs (n = 192), and SCSs (n = 71). MAIN OUTCOME MEASURE(S) Participants answered questions about nutrition resources and domains regarding basic nutrition, supplements and performance, weight management, and hydration. Adequate sports nutrition knowledge was defined as an overall score of 75% in all domains (highest achievable score was 100%). RESULTS Participants averaged 68.5% in all domains. The ATs (77.8%) and SCSs (81.6%) had the highest average scores. Adequate knowledge was found in 35.9% of coaches, 71.4% of ATs, 83.1% of SCSs, and only 9% of athletes. The most used nutrition resources for coaches, ATs, and SCSs were registered dietitians. CONCLUSIONS Overall, we demonstrated that ATs and SCSs have adequate sports nutrition knowledge, whereas most coaches and athletes have inadequate knowledge. Athletes have frequent contact with ATs and SCSs; therefore, proper nutrition education among these staff members is critical. We suggest that proper nutrition programming should be provided for athletes, coaches, ATs, and SCSs. However, a separate nutrition program should be integrated for ATs and SCSs. This integrative approach is beneficial for the continuity of care, as both categories of professionals might be developing and integrating preventive or rehabilitative programs for athletes.