Miracle-dz/UniFAR-FTUs huggingface dataset:
TARGET-BASED TEAMWORKING : GROUPS , WORK AND INTERDEPENDENCE IN THE UK CIVIL SERVICE Author Profiles

In terms of its implications for work and productio n, studies of teamworking have generally relied on concepts of autonomy and flexibility. An in-depth, qualitative case study of the UK Inland Revenue reveals a form of teamworking in whi ch both autonomy and flexibility play little part. It is argued that teamworking in this case is best conceptualised by giving greater weight to interdependence. In particular, teamwork ing in the Inland Revenue works through the outcome interdependence engendered by the empha sis on group or team work targets. This form of teamworking is given the name ‘targetbased teamworking’. Certain aspects of the nature of production appear to encourage this f orm of teamworking. More generally, the case promotes interdependence as a means of underst anding teamworking, and suggests that the key to this understanding is an analysis of the relationship between interdependence and autonomy.
Hypertension in an Animal Model of HELLP Syndrome is Associated With Activation of Endothelin 1

Women with hypertensive forms of pregnancy such as hemolysis–elevated liver enzymes–low platelet syndrome have increased circulating endothelin 1; however, the relationship between hypertension and endothelin 1 has not been studied. Using an animal model, we sought to determine whether there was an increased activation/dysfunction of endothelin 1, the effect of endothelin 1 receptor-A blockade on hypertension and other manifestations of hemolysis, elevated liver enzymes, and low platelets syndrome. On gestational day 12, timed-pregnant rats were infused with soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEndoglin; 4.7 and 7 µg/kg) via mini-osmotic pumps for 8 days. A subset of rats were treated with receptor-A antagonist (ABT-627, 5mg/kg) for 8 days. Rats with hemolysis-elevated liver enzymes-low platelet syndrome had significantly increased hypertension (P = .0001), circulating endothelin 1 (P = .03), and a significant 3.3- and 7.2-fold increase in preproendothelin messenger RNA (mRNA) expression in the placenta and liver (P = .01 and .04). Urinary protein:creatinine ratio was significantly increased in these animals (P = .0007), and circulating factors from these rats stimulated a significant increase in endothelial cell secretion of endothelin 1 (P = .001) in an in vitro assay. Blockade of the endothelin 1 receptor A significantly decreased hypertension (P = .001), circulating endothelin 1, and interleukin 17 (P = .004 and .003), placental preproendothelin mRNA expression (P = .016), and urinary protein:creatinine ratio (P = .007) in rats with hemolysis–elevated liver enzymes–low platelet syndrome. Blockade of the endothelin 1 receptor A significantly decreased hemolysis (P = .009), liver enzymes (P = .011), and significantly increased platelet levels (P = .03) and decreased circulating CD4+ and CD8+ T lymphocytes (P = .0004 and .0001) in rats infused with sFlt-1 and sEndoglin. These data support the hypothesis that endothelin 1 activation has a critical role in pathophysiology of as hemolysis–elevated liver enzymes–low platelet syndrome.
Coverage Extension Using Power-Controlled Relaying in CDMA

In this paper, the advantages of a power- control-based relay system for a code division multiple access (CDMA) network are explored. Relay nodes are placed in the form of a ring (not necessarily circular) based on system requirements, whereby a mobile user and base station can communicate directly or through relay nodes, depending on the received signal strength. Power control through the relays will provide an added advantage to the mobile stations, because they will use less power to transmit in reverse link. An optimal route is determined using the fundamental concept of the CDMA network, which is encouraging for implementing this system in practical circumstances. Through the proper allocation of relay nodes, coverage of the overall area (cell) can be extended. Area extension results for using relay nodes in the cell area are proven analytically. Finally, this paper shows that power-controlled relaying in a CDMA network will increase the number of active users per given cell at a given time.
Classificação de Alto Nível Baseada em Entropia da Rede

Tecnicas tradicionais de classificacao que baseiam-se apenas em caracteristicas fisicas dos dados sao chamadas de classificacao de baixo nivel. Se consideram, alem dos atributos fisicos, o padrao de formacao, sao denominadas tecnicas de classificacao de alto nivel. Apresenta-se aqui o projeto de iniciacao cientifica que propoe o desenvolvimento de uma nova tecnica de classificacao de alto nivel baseada na medicao das entropias da rede antes e depois da insercao de um item a ser classificado. Este item e classificado como pertencente a classe que resultar o maior aumento nas medicoes. O metodo pode classificar os dados por sua similaridade e padrao de formacao. Em resumo, esta tecnica calcula a importância do dado para cada uma das classes.
Mechanical ventilation in patients with acute respiratory distress syndrome.

POSITIVE-PRESSURE mechanical ventilation is essential for keeping alive critically ill patients who have acute respiratory distress syndrome (ARDS), a severe but reversible lung disease characterized by a diffuse injury of the alveolar– capillary barrier. 1 The reported incidence of ARDS ranges between 1.5 and 13.5 per 100,000 population, with a mortality rate of 27– 60%. Compelling evidence has progressively emerged suggesting that mechanical ventilation, although indispensable for survival, may be detrimental to the injured lung and may increase mortality rate if inappropriately administered. 2 Ventilatory support, by supplying the deficient lung function until recovery, is aimed at achieving an arterial oxygenation that ensures adequate tissue oxygenation and provides appropriate carbon dioxide elimination. A consensus exists that these clinical objectives should be reached without applying pressures and volumes that are too high to noninjured parts of the lung. The optimum ventilatory strategy in patients with ARDS should represent a compromise between alveolar recruitment and lung overinflation that both result from mechanical ventilation–induced increase in airway pressure. 3 This article provides a critical analysis of recent experimental and clinical studies supporting this concept.
Novel chip antenna with eight spiral monopole slot structures for DVB-H applications

A printed chip type antenna using monopole spiral slot structures with system ground for digital video broadcasting-handheld (DVB-H) signal reception in the UHF band is proposed. By utilizing the eight quarter-wavelength spiral slot l a radiator in configuration. In this case, the occupied area of the monopole slot chip antenna on the system circuit board can be further reduced. Antenna has a compact size of 20×20×0.8mm3. It size is minimized so that it can be easily installed to mobile handset. The simulated and measured results show that the impedance bandwidth covers the DVT (470∼860 MHz) band with return loss |S11| than 5. The antenna can get omnidirectional radiation pattern in the whole frequency band. The measurement result is agree with simulation.
Evolving Effective Bidding Functions for Auction based Resource Allocation Framework

In this paper, we present an auction based resource allocation framework. This framework, called GPAuc, uses genetic programming for evolving bidding functions. We describe GPAuc in the context of the exam timetabling problem (ETTP). In the ETTP, there is a set of exams, which must be assigned to a predefined set of slots. Here, the exam time tabling system is the seller that auctions a set of slots. The exams are viewed as the bidding agents in need of slots. The problem is then to find a schedule (i.e., a slot for each exam) such that the total cost of conducting the exams as per the schedule is minimised. In order to arrive at such a schedule, we need to find the bidders' optimal bids. This is done using genetic programming. The effectiveness of GPAuc is demonstrated experimentally by comparing it with some existing benchmarks for exam time-tabling.
A Frequency Stabilization Circuit for The Voltage Controlled Ring Oscillator

A design of a frequency stabilization circuit for the voltage controlled ring oscillator that can stabilize the voltage source and compensate the temperature and process variation is presented here. A linear voltage source using bandgap voltage reference and a temperature and process compensated circuit used for adjusting the control voltage are introduced into the oscillator. The simulation results show that when the proposed oscillator is set at 620 MHz, the output frequency has a variation of 0.13% for the voltage source in the range 3.0 V to 3.6 V when the temperature is 27degC and the process corner is typical; the output frequency has a variation of 0.8% for the temperature range of 0degC to 120degC when the voltage source is 3.3 V and the process corner is typical; the output frequency variation changes from 34.3% to 19.1% after the compensation circuit is added for all the process corners when the temperature is 27degC.
Grading and rotational crossbreeding of beef cattle. II. Calf performance to weaning.

Purebred Angus (A), Polled Hereford (PH) and Santa Gertrudis (SG) bulls were mated to grades, two-breed and three-breed rotational crosses of these breeds (seven herds) to produce three generations (G1, G2, G3) of calves. Birth weight and weaning traits were evaluated for herd differences, heterosis and effects of various genetic components. For each generation, the mean birth weight of SG exceeded that of PH which exceeded A (P less than .05). Averaged over generations, A and PH performed similarly for daily gain, 205-d weight and 205-d weight/cow exposed while SG exceeded A and PH for these traits. For feeder score, the breeds ranked A, PH, SG. For birth weight, daily gain, 205-d weight and 205-d weight/cow exposed, breeds ranked SG, PH, A for average additive genetic effects on the traits. Heterozygotic effects due to breed crosses, averaged over the three generations, were positive for all traits and generally significant, with PH X SG displaying more heterosis than the other two crosses. The maternal effects for A and SG were greater than PH for all traits except birth weight. Of the traits studied, from 12 (205-d wt/cow exposed) to 52% (205-d wt) of the variation averaged over generations was accounted for by a partial regression model that determined breed additive, breed maternal, heterosis and average maternal heterosis effects. Also averaged over generations, from . 3 (205-d wt/cow exposed) to 1.7% (avg daily gain) additional variation was due to factors that may have included specific maternal heterosis, epistasis and linkage.
Genetic association between CARD9 variants and inflammatory bowel disease was not replicated in a Chinese Han population.

OBJECTIVE In order to investigate whether CARD9 gene is associated with IBD in Chinese Han population, we replicated 2 SNPs of CARD9 which have been reported to be significantly associated with IBD. METHODS Two SNPs were genotyped using polymerase chain reaction with sequence-specific primers in 288 patients (232 CD patients, 56 UC patients) and 274 controls. RESULTS The frequencies and distributions of alleles and genotypes of the tested SNPs were analyzed, and no significant differences were found between patients and controls. CONCLUSIONS We observed no significant association between the investigated CARD9 SNPs and the susceptibility of either CD or UC. Further studies with larger sample size focusing on different ethnicities are required to elucidate the correlation between CARD9 and IBD.
Comparison of Pinning Voltage Estimation Methods in Pinned Photodiode CMOS Image Sensors

The pinning voltage is a key design parameter of pinned photodiode CMOS image sensors which significantly affects the device performances and which is often used by manufacturers to monitor production lines and for the optimization of technological processes. This paper presents a comparative study of pinning voltage estimation methods, which are based on both electrical measurements performed on isolated test structures (or on test structures arrays) and in-pixel measurements. It is shown, with the support of simulations and experimental measurements, that not all the estimation methods provide an absolute value of the pinning voltage. Moreover, this paper demonstrates that the commonly accepted theoretical definition of the pinning voltage does not correspond to the physical parameter which is measured with the existing methods.
Single KATP channel opening in response to stimulation of AMPA/kainate receptors is mediated by Na+ accumulation and submembrane ATP and ADP changes

• KATP channels can suppress overexcitation of CNS neurons after activation of glutamatergic receptors (GluRs), and we examined this functional interaction in the brainstem and hippocampal neurons. • GluR stimulation increased the activity of single KATP channels that was not mediated by intracellular calcium, reactive oxygen species and osmotic stress, and was abolished after inhibition of sodium influx. • ATP and sodium imaging indicated that functional cross‐talk between GluRs and KATP channels is mediated by Na+‐K+‐ATPase. • GluR contributed to KATP channel opening during hypoxia in functionally intact brainstem slices and seizure‐like activity in the hippocampal slices. • We propose that neuronal activity depletes submembrane ATP, and increases ADP levels and promotes KATP channel opening that dampen uncontrolled excitation by glutamate.
In-situ performance monitor employing threshold based notifications (TheBaN)

In-situ performance monitoring offers significantly better voltage scaling potential than classic ring-oscillator based approaches as it eliminates the uncertainty due to local random variations. The major challenge of such an approach is the timely generation of signaling events to control the voltage level at the most energy efficient point still offering reliable operation. In this paper we present a novel threshold based notification scheme together with a detailed analysis of corner cases. The presented measurement results are based on an implementation in a digital signal processor in a 40nm low-power technology achieving an effective voltage margin as low as 5mV.
PACE: Prediction-based Annotation for Crowded Environments

We present a new tool we have developed to ease the annotation of crowded environments, typical of visual surveillance datasets. Our tool is developed using HTML5 and Javascript and has two back-ends. A PHP based back-end implement the persistence using a relational database and manage the dynamic creation of pages and the authentication procedure. A python based REST server implement all the computer vision facilities to assist annotators. Our tool allows collaborative annotation of person identity, group membership, location, gaze and occluded parts. PACE supports multiple cameras and if calibration is provided the geometry is used to improve computer vision based assistance. We detail the whole interface comprising an administrative view that ease the setup of the system.
Extração de Informação e Mineração de Dados no Diário Oficial de Pernambuco

O uso de técnicas de mineração de dados tem sido amplamente utilizado para o processamento de uma grande quantidade de dados documentados. No entanto, atualmente, poucos aplicativos mostraram-se efetivos para extrair e minerar dados em diários oficiais. Este trabalho tem como objetivo apresentar um método para construção de uma aplicação que usa um algoritmo para indexar conteúdo da base do Diário Oficial do Estado de Pernambuco, transformando as informações anteriormente disponíveis no texto para o formato estruturado, para aplicar uma Mineração de Dados. Para o desenvolvimento do método, a linguagem Java foi utilizada, com a possibilidade do aplicativo web. O estudo de caso baseou-se em documentos publicados no Diário Oficial de janeiro de 2007 a abril de 2017. Os resultados mostram que é possível indexar e estruturar esses dados, mas ainda há necessidade de uma melhor padronização dos dados.
An Analytical Model for Scheduling Policies in Storage Networks

The I/O routine in network storage has longer transferring time and overhead than local I/O. To well make use of the storage network bandwidth and meet demand of concurrent I/O requests, we need to find the appropriate schedule policy for I/O requests at the level of the network. The focus in the paper is on how to schedule concurrent I/O data transferring in share storage network, and to improve performance such as the response time affected by scheduling method. Our objective is to analysis the response time of concurrent requests as function their schedule order such as the sequenced, parallel and hybrid policies. We then verify our results by both the analytical method and experiment
Ectomycorrhizal fungi of whitebark pine (a tree in peril) revealed by sporocarps and molecular analysis of mycorrhizae from treeline forests in the Greater Yellowstone Ecosystem

Whitebark pine (Pinus albicaulis Engelm.) is unique as the only stone pine in North America. This species has declined 40%–90% throughout its range owing to blister rust infection, mountain pine beetle, fire suppression, and global climate change. However, intact mature and old growth forests still exist in the Greater Yellowstone Ecosystem (GYE) at high timberline elevations. This study addresses the urgent need to discover the ectomycorrhizal (ECM) fungi critical to this tree species before forests are further reduced. A study of mature whitebark pine forests across five mountain ranges in the Northern GYE confirmed 32 ECM species of fungi with the pine by sporocarp occurrence in pure stands or by identification of mycorrhizae with ITS-matching. Boletales and Cortinariales (Cortinarius) comprise 50% of the species diversity discovered. In Boletales, Suillus subalpinus M.M. Moser (with stone pines), Suillus sibericus Singer (stone pines), Rhizopogon evadens A.H. Sm. (five-needle pines), Rhizopogon spp. (.
Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy - An update.

The recent report of a new variant of Creutzfeldt-jakob disease (CJD) from the United Kingdom (1) among unusually young patients and with links to bovine spongiform encephalopathy (BSE) prompted this review of developments in this area. Transmissible spongiform encephalopathies (TSE) are rare forms of progressive neurodegenerative disorders that affect both humans and animals (2) . Characteristic features include prolonged incubation periods , spongiform changes (microscopically visible vacuoles in the parenchyma of the brain) associated with neuronal loss and a failure to induce inflammatory response (3). Other neuropathological hallmarks include astrocytosis, and occasionally the presence of kuru plaques. TSEs include CJD, variant C)D, kuru, fatal familial insomnia and Gerstmann-Strausler-Scheinker syndrome in humans, and scrapie, mink encephalopathy, BSE, chronic wasting disease of elk, feline spongiform encephalopathy and spongiform encephalopathy of exotic ungulates in various animal species ( 1,4-8). The prototype TSE in humans , CJD, has three distinct patterns. It may occur sporadically (approximately 90% of cases), through autosomal dominant inheritance (approximately 10% of cases) or through iatrogenic transmission of the infective agent (less than 1% of cases) (9 ,1 0). In iatrogenic cases, person-to-person transmission has been associated with corneal transplants, dura mater grafts, pericardia! grafts, peripheral injections of pooled pituitary gland extract (growth hormone injection) and the use of contaminated neurosurgical instruments ( 11-1 7). CJD is a rap idly fatal dementing illness that occurs worldwide, with an estimated incidence of approximately one case per million persons in an equal male:female ratio. Although the ingestion of animal brains and a history of surgical procedures have been implicated as putative risk factors, a recent reanalysis of case control studies revealed only two risk factors including a family history of CJD and a history of psychotic illness ( 18-21). Increasing evidence suggests that unconventional agents termed prion proteins (PrP), which are encoded by genes on
Desmosomal Cadherin Binding Domains of Plakoglobin (*)

Plakoglobin is a major component of both desmosomes and adherens junctions. At these sites it binds to the cytoplasmic domains of cadherin cell-cell adhesion proteins and regulates their adhesive and cytoskeletal binding functions. Plakoglobin also forms distinct cytosolic protein complexes that function in pathways of tumor suppression and cell fate determination. Recent studies in Xenopus suggest that cadherins inhibit the signaling functions of plakoglobin presumably by sequestering this protein at the membrane and depleting its cytosolic pool. To understand the reciprocal regulation between desmosomal cadherins (desmoglein and desmocollin) and plakoglobin, we have sought to identify the binding domains involved in the formation of these protein complexes. Plakoglobin comprises 13 central repeats flanked by amino-terminal and carboxyl-terminal domains. Our results show that repeats 1-4 are involved in binding desmoglein-1. In contrast, the interaction of plakoglobin with desmocollin-1a is sensitive to deletion of either end of the central repeat domain. The binding sites for two adherens junction components, α-catenin and classical cadherins, overlap these sites. Competition among these proteins for binding sites on plakoglobin may therefore account for the distinct composition of adherens junctions and desmosomes.
A Framework for Outlier Description Using Constraint Programming

Outlier detection has been studied extensively and employed in diverse applications in the past decades. In this paper we formulate a related yet understudied problem which we call outlier description. This problem often arises in practice when we have a small number of data instances that had been identified to be outliers and we wish to explain why they are outliers. We propose a framework based on constraint programming to find an optimal subset of features that most differentiates the outliers and normal instances. We further demonstrate the framework offers great flexibility in incorporating diverse scenarios arising in practice such as multiple explanations and human in the loop extensions. We empirically evaluate our proposed framework on real datasets, including medical imaging and text corpus, and demonstrate how the results are useful and interpretable in these domains.
Expression of A53T Mutant But Not Wild-Type α-Synuclein in PC12 Cells Induces Alterations of the Ubiquitin-Dependent Degradation System, Loss of Dopamine Release, and Autophagic Cell Death

α-Synuclein mutations have been identified in certain families with Parkinson's disease (PD), and α-synuclein is a major component of Lewy bodies. Other genetic data indicate that the ubiquitin-dependent proteolytic system is involved in PD pathogenesis. We have generated stable PC12 cell lines expressing wild-type or A53T mutant human α-synuclein. Lines expressing mutant but not wild-type α-synuclein show: (1) disruption of the ubiquitin-dependent proteolytic system, manifested by small cytoplasmic ubiquitinated aggregates and by an increase in polyubiquitinated proteins; (2) enhanced baseline nonapoptotic death; (3) marked accumulation of autophagic–vesicular structures; (4) impairment of lysosomal hydrolysis and proteasomal function; and (5) loss of catecholamine-secreting dense core granules and an absence of depolarization-induced dopamine release. Such findings raise the possibility that the primary abnormality in these cells may involve one or more deficits in the lysosomal and/or proteasomal degradation pathways, which in turn lead to loss of dopaminergic capacity and, ultimately, to death. These cells may serve as a model to study the effects of aberrant α-synuclein on dopaminergic cell function and survival.