Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of wind generation on voltage stability in low-voltage distribution networks

This paper aims to study and provide understanding on the impact of wind generation on voltage stability in distribution networks taking into consideration the intermittent nature of wind generation. For this purpose a 61-bus radial distribution network has been modelled in Powerworld® simulator. Wind generation is connected at different locations of the network and these locations are identified as critical points, and the level of wind penetration is varied systematically to assess the influence on voltage stability. In addition, a voltage collapse proximity indicator, based on network loadability, is employed to investigate the contribution of wind generation to voltage stability.
From ATP as Substrate to ADP as Coenzyme

Dihydroxyacetone kinases are a family of sequence-related enzymes that utilize either ATP or a protein of the phosphoenolpyruvate:sugar phosphotransferase system (PTS) as a source of high energy phosphate. The PTS is a multicomponent system involved in carbohydrate uptake and control of carbon metabolism in bacteria. Phylogenetic analysis suggests that the PTS-dependent dihydroxyacetone kinases evolved from an ATP-dependent ancestor. Their nucleotide binding subunit, an eight-helix barrel of regular up-down topology, retains ADP as phosphorylation site for the double displacement of phosphate from a phospho-histidine of the PTS protein to dihydroxyacetone. ADP is bound essentially irreversibly with a t½ of 100 min. Complexation with ADP increases the thermal unfolding temperature of dihydroxyacetone L from 40 (apo-form) to 65 °C (holoenzyme). ADP assumes the same role as histidines, cysteines, and aspartic acids in histidine kinases and PTS proteins. This conversion of a substrate binding site into a cofactor binding site reflects a remarkable instance of parsimonious evolution.
An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY.

In Escherichia coli, a signal recognition particle (SRP) has been identified which binds specifically to the signal sequence of presecretory proteins and which appears to be essential for efficient translocation of a subset of proteins. In this study we have investigated the function of E. coli FtsY which shares sequence similarity with the alpha‐subunit of the eukaryotic SRP receptor (‘docking protein’) in the membrane of the endoplasmic reticulum. A strain was constructed which allows the conditional expression of FtsY. Depletion of FtsY is shown to cause the accumulation of the precursor form of beta‐lactamase, OmpF and ribose binding protein in vivo, whereas the processing of various other presecretory proteins is unaffected. Furthermore, FtsY‐depleted inverted cytoplasmic membrane vesicles are shown to be defective in the translocation of pre‐beta‐lactamase using an in vitro import assay. Subcellular localization studies revealed that FtsY is located in part at the cytoplasmic membrane with which it seems peripherally associated. These observations suggest that FtsY is the functional E. coli homolog of the mammalian SRP receptor.
Atopic background in patients with occupational hand eczema

Of 368 patients with hand eczema examined during the years 1978–79, at a Department of Occupational Dermatology, 39% had a history of atopic disease (dermatitis, asthma, or rhinitis). 28% of the patients had or had had atopic dermatitis. The % of atopics in the patient material was highest in the age range 20–24 years, in which 57% of the patients had a history of atopic dermatitis, compared with only 11% in the age range above 35 years. Of all patients with a history of atopy, 22% had developed allergic contact dermatitis, while the corresponding figure for non‐atopics was 45% (p < =0.001). Positive patch test reactions occurred in a significantly smaller number of individuals with past or present atopic disease than in non‐atopics. Atopics had not changed jobs because of hand eczema to a greater extent, but had healed to a lesser extent after change of occupation than non‐atopics (p < 0.01).
Viewpoint: Economic evaluation of package of care interventions employing clinical guidelines

Increasingly attention is shifting towards delivering essential packages of care, often based on clinical practice guidelines, as a means to improve maternal, child and newborn survival in low‐income settings. Cost effectiveness analysis (CEA), allied to the evaluation of less complex intervention, has become an increasingly important tool for priority setting. Arguably such analyses should be extended to inform decisions around the deployment of more complex interventions. In the discussion, we illustrate some of the challenges facing the extension of CEA to this area. We suggest that there are both practical and methodological challenges to overcome when conducting economic evaluation for packages of care interventions that incorporate clinical guidelines. Some might be overcome by developing specific guidance on approaches, for example clarity in identifying relevant costs. Some require consensus on methods. The greatest challenge, however, lies in how to incorporate, as measures of effectiveness, process measures of service quality. Questions on which measures to use, how multiple measures might be combined, how improvements in one area might be compared with those in another and what value is associated with improvement in health worker practices are yet to be answered.
Intrauterine programming of coronary heart disease and stroke

We have become accustomed to the idea that the major disorders of adult life, including coronary heart disease, stroke and diabetes, arise from an interaction between influences in our adult lifestyle and a genetically determined susceptibility. Recent research, however, suggests that growth in utero may also play an important role. □ Programming, intrauterine growth, birth weight, undernutrition, coronary heart disease, stroke
A Simple Approach for Abandoned Object Detection

In this paper, we implement a low-cost solution to detect abandoned and removed objects. To detect abandoned and stolen objects, the focus is to determine static regions that have recently changed in the scene by performing background subtraction. The time and presence of static objects, which may be either abandoned or stolen, are marked on the video feed and may be used to alert security personnel. Our system can detect abandoned objects and is capable of performing this in real-time. No special sensors are required and the results are shown to be satisfactory.
External validation of severity scoring systems for acute renal failure using a multinational database

Objective:Several different severity scoring systems specific to acute renal failure have been proposed. However, most validation studies of these scoring systems were conducted in a single center or in a small number of centers, often the same ones used for their development. Therefore, it is not known whether such severity scoring systems may be widely applied. Design:Prospective clinical investigation. Setting:Intensive care units. Patients:One thousand seven hundred and forty-two intensive care unit patients with acute renal failure who were either treated with renal replacement therapy or fulfilled predefined criteria. Interventions:Demographic and clinical information and outcomes were measured. Measurements and Main Results:Scores for four acute renal failure-specific scoring systems and two general scoring systems (Simplified Acute Physiology Score II and Sequential Organ Failure Assessment) were calculated, and their discrimination and calibration were tested with receiver operating characteristic curves and Hosmer-Lemeshow goodness-of fit-tests. For the receiver operating characteristic curves, blood lactate levels were also used as a reference. All scores had an area under the receiver operating characteristic curve <0.7 (Mehta 0.670, Liano 0.698, Chertow 0.610, Paganini 0.643, Simplified Acute Physiology Score II 0.645, Sequential Organ Failure Assessment 0.675, lactate 0.639). For scores that can calculate predicted mortality, the Hosmer-Lemeshow goodness-of-fit test showed poor calibration. Conclusions:None of the scoring systems tested had a high level of discrimination or calibration to predict mortality for patients with acute renal failure when tested in a broad cohort of patients from multiple countries. A large, multiple-center database might be needed to improve the discrimination and calibration of acute renal failure scoring system.
Un leader doit-il toujours dire la vérité pour justifier ses choix ?

La notion de transparence de l'information tend aujourd'hui a etre consideree non seulement comme valeur ethique de l'entreprise mais plus concretement comme sous-tendant la mise en œuvre d'une politique moderne de "Corporate Gouvernance". Il est donc particulierement interessant d'interroger directement les dirigeants d'entreprises sur ce theme afin de savoir si leurs opinions confirment des principes apparemment approuves par tous.Nous avons eu l'opportunite de le faire aupres d'un echantillon de 120 n°1 d'entreprises sous une forme interpretative voire provocante resumee par le titre de la contribution que nous proposons. Les resultats sont assez surprenants pour etre dans un premier temps presentes puis dans un second temps commentes.
A Ricardian Analysis of the Impact of Climate Change on European Agriculture

This research estimates the impact of climate on European agriculture using a continental scale Ricardian analysis. Climate, soil, geography and regional socio-economic variables are matched with farm level data from 41,030 farms across Western Europe. We demonstrate that a median quantile regression outperforms OLS given farm level data. The results suggest that European farms are slightly more sensitive to warming than American farms with impacts from +\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$+$$\end{document}5 to -\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$-$$\end{document}32 % by 2100 depending on the climate scenario. Farms in Southern Europe are predicted to be particularly sensitive, suffering losses of -\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$-$$\end{document}5 to -\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$-$$\end{document}9 % per degree Celsius.
Characterization of a novel VIIl sub-genotype of Newcastle disease virus circulating in Iran

ABSTRACT Newcastle disease is an economically important and highly contagious disease affecting wild and domestic avian species. Despite extensive vaccination efforts within the poultry industry, Newcastle disease virus (NDV) outbreaks causing significant economic losses still occur. Rural chickens may act as a potential reservoir of NDVs for commercial poultry due to poor biosecurity and inadequate vaccination. The aim of this study was to investigate the phylogenetic relationship and molecular characterization of eight NDVs isolated from backyard poultry in Iran during 2011–2013. The complete coding sequence of fusion (F) and haemagglutinin-neuraminidase (HN) genes of eight NDVs were determined and compared with other published NDVs. Based on inter-population distances and phylogenetic topology between available NDV categories, Iranian isolates formed a novel VIIl sub-genotype distinct from previous groups designated in genotype VII. Furthermore, both F and HN genes of the Iranian isolates shared high nucleotide sequence similarity with viruses isolated in China. All viruses analysed contained a polybasic cleavage site motif (111G/RRRQKR↓F117), indicating that all isolates could be categorized as a virulent pathotype. No mutation was observed in the neutralizing epitopes of the F protein. Analysis of amino acids associated with neutralizing antigenic sites within the HN protein revealed that all isolates exhibited a unique amino acid (Q) at position 347. These results emphasize the need for strengthening the biosecurity measures implemented on village flocks and practicing a mandatory vaccination programme for local poultry. Moreover, continuous monitoring of NDVs in different species of birds can help to gain more knowledge about the evolution of this virus and prevent future panzootics.
Endometrial bleeding in postmenopausal women: with and without hormone therapy

The aim of this study was to present a review of the potential mechanisms involved in the occurrence of endometrial bleeding in postmenopausal women using hormone therapy. Selected literature on the incidence of bleeding in postmenopausal women using estrogen progestogen therapy was reviewed. The incidence of spotting and bleeding in women using continuous-combined hormone therapy was presented. Relevant articles related to the role of angiogenic factors and vasculogenesis in the endometrium, endometrial leukocytes, and endometrial metalloproteinases were used for the review. The cause or etiology of endometrial bleeding with hormone therapy is unknown. Several options are known to alter angiogenesis or be involved in tissue remodeling during normal menstruation. Vascular endothelial growth factor and thrombospondin-1 are proangiogenic and antiangiogenic factors that could cause dysfunction in vasculogenesis that could result in blood vessel fragility and bleeding. The role of pericytes in maintaining vessel morphology and integrity is discussed. Endometrial leukocytes and metalloproteinases are involved in normal menstruation, but their role in postmenopausal bleeding is not clear suggesting involvement of mechanisms in the bleeding. There is limited information on clinical investigation into the etiology of postmenopausal bleeding associated with hormone therapy. The major cause of hormone therapy-related bleeding is unknown. Alterations in angiogenic factors that could result in vascular dysfunction and vessel breakdown provide a working hypothesis as to the potential cause of vessel breakdown.
Aerosol Properties Over the Indo-Gangetic Plain: A Mesoscale Perspective from the TIGERZ Experiment

Received 14 February 2011; revised 16 June 2011; accepted 23 June 2011; published 20 September 2011. [1]High aerosol loading over the northern Indian subcontinent can result in poor air quality leading to human health consequences and climate perturbations. The international 2008 TIGERZ experiment intensive operational period (IOP) was conducted in the Indo! Gangetic Plain (IGP) around the industrial city of Kanpur (26.51°N, 80.23°E), India, during the premonsoon (April‐June). Aerosol Robotic Network (AERONET) Sun photometers performed frequent measurements of aerosol properties at temporary sites distributed within an area covering! 50 km 2 around Kanpur to characterize pollution and dust in a region where complex aerosol mixtures and semi! bright surface effects complicate satellite retrieval algorithms. TIGERZ IOP Sun photometers quantified aerosol optical depth (AOD) increases up to! 0.10 within and downwind of the city, with urban emissions accounting for! 10‐20% of the IGP aerosol loading on deployment days. TIGERZ IOP area! averaged volume size distribution and single scattering albedo retrievals indicated spatially homogeneous, uniformly sized, spectrally absorbing pollution and dust particles. Aerosol absorption and size relationships were used to categorize black carbon and dust as dominant absorbers and to identify a third category in which both black carbon and dust dominate absorption. Moderate Resolution Imaging Spectroradiometer (MODIS) AOD retrievals with the lowest quality assurance (QA"0) flags were biased high with respect to TIGERZ IOP area! averaged measurements. MODIS AOD retrievals with QA"0 had moderate correlation (R 2 = 0.52‐0.69) with the Kanpur AERONET site, whereas retrievals with QA > 0 were limited in number. Mesoscale! distributed Sun photometers quantified temporal and spatial variability of aerosol properties, and these results were used to validate satellite retrievals.
Embedding Heuristic Rules in RRT Path Planning of Excavators

Improving safety and productivity of earthwork operations is of paramount importance, especially in congested sites where collisions are more probable. Automated Machine Guidance and Control technology is expected to improve both safety and productivity of earthwork operations by providing excavator operators with higher level of support regarding the path planning of excavators based on site conditions. However, in spite of the large number of studies related to automated path planning of excavators using well established algorithms from robotics, such as Rapidly-exploring Random Tree (RRT) and Probabilistic Roadmaps (PRM). These studies do not fully consider the engineering constrains of the equipment and do not result in smooth and optimal paths that can be applied in
High growth rate and substrate exhaustion results in rapid cell death and lysis in the thermophilic bacterium Geobacillus thermoleovorans

Batch cultures of the thermophilic bacterium Geobacillus thermoleovorans T80 attained extremely high‐specific glucose utilization rates leading to high specific growth rates, followed by extensive cell death and lysis with the onset of substrate exhaustion. The dramatic decrease in live cell numbers, as determined by flow cytometry, was accompanied by the release of soluble protein. Once the growth phase reached the point of commitment to lysis created by the impending exhaustion of substrate, the addition of extra carbon substrate did not halt the rapid death rate and lysis, although, towards the end of the exponential growth phase, the substrate was utilized producing only a small additional biomass concentration as a result of the net effect of cell growth and death. This lytic phenomenon was observed when a range of different carbon substrates (glucose, pyruvate, acetate, n‐hexadecane, nutrient broth), as well as ammonium (the nitrogen source) in the presence of excess carbon source, reached near exhaustion. The rate and extent of cell death and the ensuing lysis depend on the culture growth rate. Cultures batch grown with a lower initial substrate concentration, or at a lower temperature, or at lower dilution rates for continuous‐flow cultures, exhibited a lower rate and extent of cell death and lysis. Batch re‐culture of the persister cells resulted in a behavior identical to that of the original culture indicating that these cells were not genetically modified. The glucose utilization, cell growth and death rates were mathematically described based on Monod kinetics and estimated values of pertinent biokinetic constants are reported. © 2006 Wiley Periodicals, Inc.
Identificação de epítopos de célula B na glicoproteína-E do envelope do vírus dengue sorotipo 3

As infeccoes pelo virus dengue tem se tornado um problema crescente de Saude Publica em regioes tropicais e subtropicais do mundo. O virus pertence a familia Flaviviridae com quatro sorotipos antigenicamente distintos (DENV-1 a DENV-4). Uma possivel estrategia para evitar a patogenia associada com uma vacina para o dengue (que deve ser tetravalente), seria a construcao de uma vacina quimerica composta de epitopos criticos selecionados dos quatro sorotipos. A maioria dos epitopos envolvidos na neutralizacao do virus esta presente na glicoproteina E do envelope, que e a maior proteina de superficie da particula viral. O objetivo deste trabalho foi identificar epitopos de celula B na glicoproteina E do virus dengue sorotipo 3. Para o mapeamento de epitopos imunodominantes, noventa e cinco peptideos (15-mers cada, sobreposicao de 10) foram sintetizados (Synpep, California-USA), a partir da sequencia de 490 aminoacidos da glicoproteina E do envelope do DENV-3, de cepa circulante no Brasil. Estes peptideos foram testados por ELISA contra um pool de soros de pacientes positivos e negativos para dengue, coletados durante a fase de convalescenca da infeccao por DENV-3. Os resultados mostraram que os soros de humanos reagiram com onze, dos noventa e cinco peptideos testados, distribuidos em 5 regioes com aminoacidos na posicoes 51-65 (peptideo 11), 71-90 (peptideos 15 e 16), 131-170 (peptideos 27, 28, 29, 30, 31 e 32), 196-210 (peptideo 40) e 246-260 (peptideo 50). A analise da curva ROC mostrou que, dentre os peptideos identificados, nove seriam capazes de diferenciar entre pacientes com DENV-3 de pacientes nao-dengue e tres capazes de diferenciar a infeccao por DENV-3 daquelas por outros sorotipos virais (DENV-1 e DENV-2). Os epitopos imunodominantes aqui descritos, junto com outros epitopos bem documentados, sao potencialmente relevantes para o desenho de uma vacina para o virus dengue e para o desenvolvimento de kits de diagnostico especificos.
Trouble de l’écriture révélateur d’un accident vasculaire cérébral ischémique: à propos d’un cas

Les auteurs rapportent un cas d’un accident vasculaire cerebral ischemique constitue diagnostique fortuitement suite a un trouble de l’ecriture chez une patiente enseignante, agee de 37 ans, avec antecedent d’hypertension arterielle. L’examen neurologique a conclu a une dysgraphie peripherique et les examens paracliniques faits nous ont permis de mettre en evidence cet accident ischemique constitue. La difficulte pour cette patiente a pouvoir ecrire correctement une phrase nous a permis de conclure a la responsabilite de sa main droite dans l’ensemble des erreurs observees. Le trouble de l’ecriture serait reste inapercu si cette patiente n’avait pas ete enseignante.