Miracle-dz/UniFAR-FTUs huggingface dataset:
Gamma Dose Rate Measurements in Kuwait Using a Car-Borne GPS Integrated Dosimetric System

A mobile system comprising of a Geiger-Muller (GM) dosimeter connected with a smart phone was used for ambient gamma dose rate survey within the districts and on the roads within the state of Kuwait. While the dosimeter provides data on gamma dose rates, the smart phone provides the GPS navigation information and saves the data for subsequent analysis and mapping. The survey covered a total distance of about 2300 km within the country and 3117 data points were recorded to show the dose rate distribution on the map of Kuwait. The results show that the ambient dose rates in Kuwait range from 40 to 180 nSv.h-1 with a mean value of 103 nSv.h-1. The dosimetric system described has good potential as a tool for determining baseline background radiation dose rates in an area.
A study on the new approaches for social network based recommendations in digital marketing

Social interactions can be inferred on the web using the mailing list and home page links. It also represents the social lives of the individuals, collaborations, communities and relationship. Social networking groups are becoming increasingly important due to the volume and activities. Thus, the structure of the network, connectivity, movement of members from one group to another and change of interest are important for further investigation. Users on social networking websites maintain an explicit, self-craft run-down of their own interest and zeal, mentioned using free-form natural language. The main focus of this work is to find out the information hub or influential node which has large number of contacts in Online Social Network and recommends relevant advisement so that the product or service reaches a vast number of friends or users within the advertisement budget.
BURN INJURY INDUCES AN EARLY ACTIVATION RESPONSE BY LYMPH NODE CD4+ T CELLS

ABSTRACT Several reports have shown that burn injury primes the immune system for an early and vigorous proinflammatory CD4 T cell response, suggesting that injury might signal CD4 T cell activation. We addressed this possibility by investigating changes in CD4 T cell activation marker expression, proliferation, and T cell receptor (TCR) usage at several early time points after burn injury. Using a sensitive flow cytometry approach to measure changes in the expression of Ki-67 antigen, a nuclear protein detected only in proliferating cells, we observed an early burst of proliferation by lymph node, but not spleen, CD4+ T cells 12 h after burn injury. In contrast, mice that were treated with the bacterial superantigen staphylococcal enterotoxin B (SEB) as a positive control for in vivo T cell activation did not show this early proliferation. Instead, we observed a significant increase in proliferating lymph node and spleen CD4 and CD8 T cells by 3 days after SEB treatment. Burn injury induced higher cell surface CD25 and CD152 expression on lymph node CD4+ T cells, whereas SEB treatment increased CD25 and CD69 expression on CD4+ and CD8+ T cells. Finally, we found that burn injury induced a proliferative response at 12 h by an oligoclonal subset of TCR V&bgr;-chain-expressing CD4+ T cells (V&bgr;4, V&bgr;6, V&bgr;11, and V&bgr;14). Interestingly, CD4+ T cells expressing the V&bgr;11-TCR remained significantly increased in the lymph nodes 3 days after burn injury. Taken together, these findings indicate that burn injury induces an early proliferation and activation of CD4+ T cells in the regional lymph nodes and that these proliferating cells show restricted TCR V&bgr;-chain usage consistent with the idea that injury triggers an early T cell activation signal.
Molecular signatures of pancreatic cancer.

CONTEXT The introduction of genome- and epigenome-wide screening techniques has dramatically improved our understanding of the molecular mechanisms underlying the development of pancreatic cancer. There are now 3 recognized histologic precursors of pancreatic cancer: pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. Each of these precursor lesions is associated with specific molecular alterations. OBJECTIVE To understand the molecular characteristics of pancreatic ductal adenocarcinoma and its precursor lesions. DATA SOURCES PubMed (US National Library of Medicine). CONCLUSIONS In this review, we briefly summarize recent research findings on the genetics and epigenetics of pancreatic cancer. In addition, we characterize these molecular alterations in the context of the histologic subtypes of pancreatic cancer.
of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln Brown· Midrib Sorghum Silage for Midlactation Dairy Cows Brown· Midrib Sorghum Silage for Midlactation Dairy Cows

Brown midrib sorgbumsilase was compared with alfalfa. com. and normal sorghum silages for its, effect on perfOt. mance. 1'1lD1i,nal meta~lism. '·and diges tive ki,etfcs of Holstein dairy cows in midla'Ctation. Twelve cows·,·averaging· 90 ± S DIM were. assigned to one of four diets'" in replicated 4 X 4 Latin . squares with 4-wk periods. Additionally, 3 rumi nally fistulated cows (95 * 20 DIM) were assigned to the saniedietsina 3x 4 Youcien square for measl1Il'ment ofrumi nal characteristics. Diets were fed as isonitrogenous TMR that contained 65% silage (OM basis). The DMl was greater for the corn and brown midrib sorghum (4% of BW/d) than for the alfalfa and no~ sorghum diets (3.4% of~W/d). The brown. midrib . sorghum supported FCM production that was similar to that of cows on corn aDd alfalfa diets (25.8 kg/d), but cows fed normal sorghum produced less milk and fewer milk Com· ponents. Source' of silage had no effect on eating. time, but rumination, was leas! for the alfalfa.diet. Ruminal pH· and atn monia concentrations . were similar for all diets. Total VFAconcentrations were greatest for the corn 'and brown· midrib sorghum diets. The brown midrib sor· ghum had greater in situ extent of ruJIu nal NDF digestion than did the normal sorghum, which agreed with in vitro data. The brown midrib sorghum used in this experiment supported FCM produc tion similar to the corn and alfalfa silases commonly fed to dairy cows in midlilctation.
Evaluation of Some Biological Activities of Albizia lebbeck Flowers

Reviewing the current literature for the importance of the plant Albizia lebbeck L. growing worldwide revealed many biological interests. However, the species growing in Saudi Arabia has not received due attention. The present study was undertaken to study antipyretic, analgesic, estrogenic and anti-inflammatory activities of five different fractions from successive extraction of Albizia lebbeck flowers: n hexane, dichloromethane, ethyl acetate, n-butanol as well as the 70% total alcohol. The flowers showed reasonable antipyretic, analgesic, estrogenic and anti-inflammatory activities.
Ziconotide: a new nonopioid intrathecal analgesic for the treatment of chronic pain

Ziconotide is a new nonopioid intrathecal agent recently approved for the treatment of chronic pain. Ziconotide is indicated for the management of severe chronic pain in patients for whom intrathecal therapy is warranted and who are intolerant of or refractory to other treatment, such as systemic analgesics, adjunctive therapies or intrathecal morphine. Ziconotide blocks the N-type calcium channels located in the superficial dorsal horn of the spinal cord, resulting in potent analgesia. The efficacy of ziconotide has been demonstrated in three randomized, placebo-controlled trials in over 500 patients. In addition, its safety has been demonstrated in over 1200 subjects. Ziconotide is a potent analgesic with a narrow therapeutic window. The drug requires a slow titration in order to achieve analgesia while avoiding dose-limiting side effects. This review examines the currently available information on this new analgesic.
Manipulation control of an armed Ballbot with stabilizer

Combination of a mobile platform and a manipulator which is known as a mobile manipulator can be used in lots of applications. Motion control with respect to stability of dynamically stable mobile manipulators is one of the interesting challenges in robotics. In addition, servant robots are becoming widespread, from local uses as robotic cleaner to field applications as flexible robots, also for farming, martial, and space exploration. One of the servant robots that are designed to operate specially in indoor places is the Ballbot. A Ballbot is an under-actuated system with non-holonomic dynamic constraints. It is as tall as human height until it could interact by people. Moreover, it can be equipped with a manipulator for grasping and manipulating objects. So, manipulation control of such system is highly complicated due to severe under-actuated condition and non-linear dynamics which is considered in this article. Therefore, developing a compact dynamic model is highly practical for controller design, developing simulation studies in support of design improvement, and for useful applications. To this end, the Ballbot has been equipped with a Programmable Universal Machine for Assembly–type manipulator. This manipulator adds new advantages to the Ballbot such as an object manipulation operation and better stability. So, the dynamic model of the proposed system without any simplicity is presented, and then, the validation of this extracted model is studied. Next, the manipulator reconfiguration is used to help the system move without flutter. Because of the passive joints, the Ballbot cannot maintain its stability and follows the desired end-effector trajectory. Therefore, a stabilizing pendulum is proposed to help the stability of the system when the manipulator handles an object on the desired path. Finally, a manipulation control algorithm is proposed to reach the system to its desired position. Simulation results show the capability of the presented controllers.
Textural classification of B & W aerial photos for the forest classification

The Ministry of agriculture of the Czech Republic has defined a pilot project to summarize possible information that can be automatically evaluated from black and white aerial photos. This information should serve as input data into the large forest database or as signal data for forest state management organizations. These data were derived in traditional and modern ways. The traditional one used well-known principles of image processing as image distraction and thresholding. Modern tools were applied for other tasks using Fractal Net Evolution Approach commercially introduced by Baatz and Schäpe (1999) incorporated in commercial software eCognition for image segmentation and further classification where not only black and white aerial photos were used but also texture measures of these B&W aerial photos. The textural classification as another way used results of the detailed object oriented classification. The methodology was tested in another project defining the geodynamical model of land. The result of the project is a methodology to delineate forest areas, to distinguish deciduous and coniferous forest, to detect new deforestation and new large illegal dumpings and erosional rills from two different time level aerial photos. These tasks also include uninsured forest area detection. It means to determine six year-old forest (and younger).
Pharmacological management of attention-deficit hyperactivity disorder

Pharmacotherapy is the most common intervention for attention-deficit hyperactivity disorder (ADHD). Stimulant medications are highly efficacious and are the gold-standard for treating the inattention, impulsivity and excessive motoric activity associated with ADHD. Methylphenidate and amphetamine-based stimulants are now available in longer-acting, once-daily and shorter-acting divided dosing schedules. Several nonstimulant, second-line treatments are now available or under development for the treatment of ADHD in children and adults. This article reviews the support for a variety of pharmacological agents and the issues to be considered when selecting an agent. The authors conclude that there is a need for additional direct comparisons between the longer-acting agents to effectively guide the practicing clinician.
TOPIC REVIEW: Diagnostic work-up of early rheumatoid arthritis in the foot and ankle patient

Rheumatoid arthritis is a chronic, progressive disease that affects the synovial membranes of joints, and leads to bone and cartilage destruction of both small and large joints in the upper and lower extremities. Foot and ankle specialists may be the first providers to recognize symptoms at their earliest stages. As first line providers a good understanding of the disease and its classification criteria is imperative. Diagnostic work-up requires patient history, physical examination, imaging modalities, and laboratory markers. A literature review and review of updated diagnostic criteria are presented.
An uncommon presentation of non-Hodgkin's lymphoma: Diffuse large-cell lymphoma presenting as a peritoneal mass

Diffuse large B-cell lymphoma (DLBCL) is the most common histological variant of non-Hodgkin’s lymphoma (NHL) in adults, accounting for 30 – 40% of cases. In general terms, these develop from nodes, although up to 40% of cases may present as extranodal tumors [1]. Gastrointestinal DLBCL is the most frequent extra-nodal lymphoma, with the most common location below the diaphragm, followed by the small intestine and colon – rectum [2]. We present an unusual, atypical case of diffuse large B-cell lymphoma involving only the peritoneum. The patient was a Caucasian male, aged 62 years, who presented with a 1-month history of intermittent colic abdominal pain, together with anorexia, asthenia and weight loss of at least 6 kg. The patient reported no fever, sweating or digestive symptoms. On physical examination, the only finding was a mass in the right hypochondrium, with no peripheral adenopathies or splenomegaly. Total blood count tests showed: hemoglobin 11.5 g/dl, white blood cell count 6.756 10/mm and platelets 2056 10/mm. Serum biochemistry was also examined for lactate dehydrogenase levels and renal and liver function tests. The results of the tests were normal, as were both the B2 microglobulin determination and chest X-ray. Thoraco-abdominal-pelvic computerised tomography (CT) revealed a heterogeneous 7-cm mass on the abdominal wall and surface of the liver, as well as multiple omental and peritoneal nodules (Figure 1). No signs of ascites or other cavity effusions were found. Based on the CT findings, consideration was given to differential diagnosis between disseminated gastrointestinal carcinoma and disseminated pancreatic carcinoma. A biopsy taken from the abdominal mass showed diffuse lymphoid proliferation, with clear cytoplasmic cells, large, round nuclei, occasional indentations and a central nucleolus. Immunohistochemistry tests showed intensive positivity to the common leukocyte antigen and CD20. These findings confirmed the diagnosis of diffuse large B-cell NHL (Figure 2). Following this histology-based diagnosis, the patient underwent further work-up, including pharyngolaryngoscopy, gastroduodenal endoscopy with multiple biopsies, complete colonoscopy and unilateral bone marrow biopsy. No further nodal or extra-nodal site of the disease was found. As a result, the patient was staged as Stage IVAE, given the multiple peritoneal involvement. Serology tests for HIV, Epstein-Barr virus (EBV), human herpesvirus type 8 (HHV-8), hepatitis B virus and hepatitis C virus were negative, ruling out any possible association of the lymphoma with the patient’s immunodeficiency status or viral infection. The patient was treated with combined chemotherapy, comprising R-CHOP (rituximab, cyclophosphamide, adriamycin, vincristine and prednisolone) every 21 days, up to a total of six cycles. Complete
Interaction of calcium nutrition and physical activity on bone mass in young women

We have examined the relationships among calcium intake, mechanical stress (activity) and axial (lumbar) and peripheral (midradius) bone mass in a population of 60 young normal, healthy eumenorrheic women (age 25–34 years), selected on the basis of weight for height (within 20% of expected). In this population, vertebral bone mineral density was significantly related (r = 0.41, p < 0.005) to activity pattern but not to calcium intake. Elimination of the effects of activity, however, disclosed a significant correlation between total calcium intake and vertebral bone mass (r = 0.36, p < 0.02). Closer examination of this relationship suggested that vertebral bone mineral density did not appear to increase with calcium intakes above 800–1000 mg/day, implying a threshold effect and vertebral density was better expressed as a function of the logarithm of calcium intake (r = p < 0.01). Radial mineral content was not related to activity (which was mostly walking and running), but it was significantly affected by calcium intake. These data suggest that skeletal status in the vertebrae in young women may be influenced by modulation of mechanical stress. However, bone mineral density is probably also dependent on nutritional status such that the optimum calcium intake for this effect is 800–1000 mg/day. If such effects, observed here cross‐sectionally, can be substantiated in longitudinal studies and persist into the aging postmenopausal population, then the average age of onset of osteoporotic fractures would be expected to be delayed approximately 10 years, by relatively simple modifications of diet and activity.
Traditional SCORE-based health check fails to identify individuals who develop acute myocardial infarction.

INTRODUCTION Atherosclerotic cardiovascular disease (CVD), including acute myocardial infarction (AMI), is caused by well-known risk factors. They constitute important therapeutic targets, but their predictive value is disputed. We evaluated the effectiveness of the risk scoring system (SCORE) and thresholds for pharmacotherapy re-commended in the European guidelines on CVD prevention. MATERIAL AND METHODS The medical records of 605 consecutive patients hospitalized for a first AMI were reviewed. Patients with pre-existing CVD, diabetes, or incomplete information on risk factors were excluded. Those not treated with statin before AMI were risk stratified based on risk factors. A SCORE ≥ 5% or ≥ 10% was considered to qualify for preventive medication in young adults (age ≤ 60 years) or elderly (age > 60 years), respectively. RESULTS Before AMI, 40 (9%) used statin. Among non-statin users, only five of the 109 young adults had a SCORE ≥ 5%, and 23 of the 284 elderly had a SCORE ≥ 10%. Among women, only three elderly qualified for treatment. More than four times more patients would have qualified for treatment with the high-risk country chart used in 2011. The incremental value of the novel high-density lipoprotein adjusted SCORE charts was limited. CONCLUSION Few patients admitted with a first AMI used statin. Among non-statin users, SCORE and the recommended thresholds for pharmacotherapy identified no women and less than one out of ten men who untreated were destined for an AMI before 61 years of age. The preventive potential of a traditional risk factor-based health check is limited. FUNDING not relevant. TRIAL REGISTRATION not relevant.
Using a secure element to protect the users' profiles generated by web search engines

Web search engines (WSEs) are valuable tools that are widely used to find specific information in the World Wide Web. Recently, they have increased search result relevance by personalizing them according to the users’ interests. Nevertheless, WSEs also pose an important privacy threat, as they profile users by storing and analyzing their previous search data. To address this privacy problem, current solutions propose new mechanisms that add a significant computation and communication overhead, and/or lack personalized search results. In this paper we present a server-side web search model that serves personalized search results while preserving the privacy of the users. In this model, a mechanism called the secure element (SE) acts as an intermediary between the web search engine and end users. The secure element forwards queries from the users to the WSE and later re-ranks search results according to the user’s previous search behavior. All communication between the users and the secure element is encrypted to prevent eavesdropping. A privacy analysis shows that the scheme effectively protects users from being profiled by WSEs or external attackers.
The International Journal of Biostatistics Survival Curve Estimation with Dependent Left Truncated Data Using Cox ' s Model

The Kaplan-Meier and closely related Lynden-Bell estimators are used to provide nonparametric estimation of the distribution of a left-truncated random variable. These estimators assume that the left-truncation variable is independent of the time-to-event. This paper proposes a semiparametric method for estimating the marginal distribution of the time-to-event that does not require independence. It models the conditional distribution of the time-to-event given the truncation variable using Cox's model for left truncated data, and uses inverse probability weighting. We report the results of simulations and illustrate the method using a survival study.