Miracle-dz/UniFAR-FTUs huggingface dataset:
Factor Structure and Reliability of the Posttraumatic Cognitions Inventory in Korean Female Victims of Sexual Violence

Trauma-related cognitions play an important role in formation and persistence of posttraumatic stress symptoms. This study investigated the psychometric properties of the Korean version of the Posttraumatic Cognitions Inventory (PTCI) in a sample of 227 females who had experienced sexual violence. Data were collected from victims who sought victim support services following sexual violence between 2011 and 2015. The Impact of Event Scale–Revised, Beck Depression Inventory, and Beck Anxiety Inventory were used to measure posttraumatic stress disorder severity, depression, and anxiety, respectively. The three-factor solution of the PTCI (SELF, WORLD, BLAME) was supported; however, it was necessary to remove five items from the original 33-item scale. The 28-item PTCI displays good internal consistency, concurrent validity, and discriminant validity. SELF and WORLD subscales correlated with trauma symptom severity, controlling depression and anxiety. This is the first study to investigate factor structure and psychometric properties of the Korean version of the PTCI with female victims of sexual violence, which demonstrated that 28-item version of PTCI is an acceptable assessment measure of examining trauma-related cognitions.
HIV-1 Induces Telomerase Activity in Monocyte-Derived Macrophages, Possibly Safeguarding One of Its Reservoirs

ABSTRACT Monocyte-derived macrophages (MDM) are widely distributed in all tissues and organs, including the central nervous system, where they represent the main part of HIV-infected cells. In contrast to activated CD4+ T lymphocytes, MDM are resistant to cytopathic effects and survive HIV infection for a long period of time. The molecular mechanisms of how HIV is able to persist in macrophages are not fully elucidated yet. In this context, we have studied the effect of in vitro HIV-1 infection on telomerase activity (TA), telomere length, and DNA damage. Infection resulted in a significant induction of TA. This increase was directly proportional to the efficacy of HIV infection and was found in both nuclear and cytoplasmic extracts, while neither UV light-inactivated HIV nor exogenous addition of the viral protein Tat or gp120 affected TA. Furthermore, TA was not modified during monocyte-macrophage differentiation, MDM activation, or infection with vaccinia virus. HIV infection did not affect telomere length. However, HIV-infected MDM showed less DNA damage after oxidative stress than noninfected MDM, and this resistance was also increased by overexpressing telomerase alone. Taken together, our results suggest that HIV induces TA in MDM and that this induction might contribute to cellular protection against oxidative stress, which could be considered a viral strategy to make macrophages better suited as longer-lived, more resistant viral reservoirs. In the light of the clinical development of telomerase inhibitors as anticancer therapeutics, inhibition of TA in HIV-infected macrophages might also represent a novel therapeutic target against viral reservoirs.
What really happens to people on long-term peritoneal dialysis?

BACKGROUND Several risk factors for patients treated with peritoneal dialysis (PD) have now been identified. These include age, comorbid disease, nutritional status, loss of residual renal function (RRF) and high peritoneal solute transport. This is not the same, however, as knowing what actually happens to these patients, particularly in the long-term. The purpose of this review was to give as complete a description as is currently possible of the long-term PD patient. METHODS The literature was surveyed for publications that provide longitudinal cohort data of either selected or unselected patient groups. Detailed data from the Stoke PD Study is presented in the context of these studies. Three principle aspects of what really happens to patients were considered: (1) death, both cause and mode of death; (2) technique failure, with reference to peritoneal function and how the cause of technique failure related to patient survival; and (3) evolution of clinically relevant parameters of patients on PD, such as nutrition and peritoneal function. RESULTS Sudden death and debilitation were the predominant modes of death, with sepsis playing a contributory role. Debilitation was important regardless of co-existent comorbid disease, and time to death was not influenced by the mode of death. Predominant causes for technique failure remain peritonitis and ultrafiltration, the latter becoming more important with time on treatment. Technical failure is associated with poorer survival, particularly when due to multiple peritonitis or failure to cope with treatment. Cox regression demonstrated that whereas low albumin, loss of RRF and high solute transport predicted patient death, only high solute transport predicted technique failure. Longitudinal changes over the first five years of treatment included loss of RRF, increasing solute transport and following an initial improvement in nutritional state, a decline after two years. Patients surviving long-term PD (at least five years, N = 25) were characterized by prolonged RRF, maintained nutrition and lower solute transport in the medium term. CONCLUSIONS Several studies of long-term PD in the literature now complement each other in providing a picture of what really happens to PD patients. The links between loss of solute clearance and poor peritoneal ultrafiltration combining to exacerbate sudden or debilitated death and technique failure are emerging. For PD to be successful as a long-term therapy, strategies that maintain nutrition and preserve peritoneal membrane function must be developed.
Rate of repair in minimally invasive mitral valve surgery.

BACKGROUND Valve repair has been shown to be the method of choice in the treatment of patients with severe mitral valve regurgitation. Minimally invasive surgery has raised skepticism regarding the rate of repair especially for supposedly complex lesions, when anterior leaflet involvement or bileaflet prolapse is present. We sought to review our experience of all our patients presenting with degenerative mitral valve regurgitation and operated on minimally invasively. METHOD From September 2006 to December 2012, 842 patients (mean age 56.12±11.62 years old) with degenerative mitral valve regurgitation and anterior leaflet (n=82, 9.7%), posterior leaflet (n=688, 81.7%) and bileaflet (n=72, 8.6%) prolapses were operated on using a minimally invasive approach. RESULTS 836 patients had a valve repair (99.3%) and received a concomitant ring annuloplasty (mean size, 33.7; range, 28-40). Six patients (0.7%) underwent valve replacement. Two patients had a re-repair due to MR progression or infective endocarditis. Thirty-day mortality was 0.2% (two patients). There were 60 major adverse events (MAE) (7.1%). CONCLUSIONS A minimally invasive approach allows repair of almost all degenerative valves with good short-term outcomes in a tertiary referral center, when using proven and efficient surgical techniques.
Data Recovery in IBM Database 2

This paper presents the various forms of data recovery provided by IBM Database 2 (DB2). It describes the DB2 recovery log, introduces the notion of a unit of recovery, and discusses the two-phase commit protocol used by DB2. Furthermore, it describes what type of information is logged, the DB2 checkpoint process, what a compensation log record is, and how DB2 handles undo/redo processing, media recovery, restart after abnormal system termination, and data unavailability.
Matrix metalloproteinases may contribute compensationally to tumor invasion in T1 colorectal carcinomas.

BACKGROUND Few investigators have focused on possible interactions among several MMPs collectively. MATERIALS AND METHODS Immunostaining for MMP-7, MMP-2 and MT1-MMP was performed on 51 early invasive (T1) colorectal carcinomas, and correlations between the expressions of pairs of MMPs were examined. RESULTS MMP-7 expression was positive at the invasive front in 18 (35%) out of 51 tumors. Cytoplasmic MMP-2 expression was positive in 20(39%) out of 51 tumors, whereas its expression in the stroma was positive in 17(33%) out of 51 tumors. MT1-MMP was localized predominantly in the tumor cell cytoplasm in 14 (27%) out of 51 tumors. There was an inverse correlation between MMP-7 and cytoplasmic MMP-2 expression with marginal significance (p = 0.06), and between MMP-7 and MT1-MMP expression with statistical significance (p = 0.01). The association between cytoplasmic MMP-2 and MT1-MMP expression was statistically significant (p = 0.0004). CONCLUSION MMP-7 and MMP-2 or MT1-MMP may contribute compensationally to tumor invasion and metastasis in T1 colorectal carcinomas.
Decomposing conformance checking on Petri nets with data

Process mining techniques relate observed behavior to modeled behavior, e.g., the automatic discovery of a Petri net based on an event log. Process mining is not limited to process discovery and also includes conformance checking. Conformance checking techniques are used for evaluating the quality of discovered process models and to diagnose deviations from some normative model (e.g., to check compliance). Existing conformance checking approaches typically focus on the control flow, thus being unable to diagnose deviations concerning data. This paper proposes a technique to check the conformance of data-aware process models. We use so-called "data Petri nets" to model data variables, guards, and read/write actions. Additional perspectives such as resource allocation and time constraints can be encoded in terms of variables. Data-aware conformance checking problem may be very time consuming and sometimes even intractable when there are many transitions and data variables. Therefore, we propose a technique to decompose large data-aware conformance checking problems into smaller problems that can be solved more efficiently. We provide a general correctness result showing that decomposition does not influence the outcome of conformance checking. Moreover, two decomposition strategies are presented. The approach is supported through ProM plug-ins and experimental results show that significant performance improvements are indeed possible.
Multifunctional T Cell Response to DosR and Rpf Antigens Is Associated with Protection in Long-Term Mycobacterium tuberculosis-Infected Individuals in Colombia

ABSTRACT Multifunctional T cells have been shown to be protective in chronic viral infections. In mycobacterial infections, however, evidence for a protective role of multifunctional T cells remains inconclusive. Short-term cultures of peripheral blood mononuclear cells stimulated with the Mycobacterium tuberculosis RD1 antigens 6-kDa early secretory antigenic target (ESAT6) and 10-kDa culture filtrate antigen (CFP10), which are induced in the early infection phase, have been mainly used to assess T cell multifunctionality, although long-term culture assays have been proposed to be more sensitive than short-term assays for assessment of memory T cells, which are essential for long-term immunity. Here we used a long-term culture assay system to study the T cell immune responses to the M. tuberculosis latency-associated DosR antigens and reactivation-associated Rpf antigens, compared to ESAT6 and CFP10, in patients with pulmonary tuberculosis (PTB) and household contacts of PTB patients with long-term latent tuberculosis infection (ltLTBI), in a community in which M. tuberculosis is endemic. Our results showed that the DosR antigens Rv1737c (narK2) and Rv2029c (pfkB) and the Rv2389c (rpfD) antigen of M. tuberculosis induced higher frequencies of CD4+ or CD8+ mono- or bifunctional (but not multifunctional) T cells producing interferon gamma (IFN-γ) and/or tumor necrosis alpha (TNF-α) in ltLTBI, compared to PTB. Moreover, the frequencies of CD4+ and/or CD8+ T cells with a CD45RO+ CD27+ phenotype were higher in ltLTBI than in PTB. Thus, the immune responses to selected DosR and Rpf antigens may be associated with long-term latency, correlating with protection from M. tuberculosis reactivation in ltLTBI. Further study of the functional and memory phenotypes may contribute to further discrimination between the different states of M. tuberculosis infections.
Neural network-based position synchronised internal force control scheme for cooperative manipulator system

ABSTRACT More complex problems of simultaneous position and internal force control occur with cooperative manipulator systems than that of a single one. In the presence of unwanted parametric and modelling uncertainties as well as external disturbances, a decentralised position synchronised force control scheme is proposed. With a feedforward neural network estimating engine, a precise model of the system dynamics is not required. Unlike conventional cooperative or synchronised controllers, virtual position and virtual synchronisation errors are introduced for internal force tracking control and task space position synchronisation. Meanwhile joint space synchronisation and force measurement are unnecessary. Together with simulation studies and analysis, the position and the internal force errors are shown to asymptotically converge to zero. Moreover, the controller exhibits different characteristics with selected synchronisation factors. Under certain settings, it can deal with temporary cooperation by an intelligent retreat mechanism, where less internal force would occur and rigid collision can be avoided. Using a Lyapunov stability approach, the controller is proven to be robust in face of the aforementioned uncertainties.
Robust dichotomy for nonlinear uncertain systems

In this paper, properties of dichotomy for nonlinear systems with norm-bounded uncertainty are considered. By using some results of H∞ theory and method of linear matrix inequality (LMI) some criterions of testing robust dichotomy of uncertain nonlinear systems are given. An approach of designing state feedback controller guaranteeing dichotomy of closed loop systems with norm-bounded uncertainty is proposed. The given results are applied to Chua's circuit. A numerical algorithm of designing a controller guaranteeing dichotomy of the closed-loop system is presented which enlarges the range of some parameters.
Barriers to the use of patient-reported outcomes in clinical care.

I am conflicted in writing this Editorial Perspective. For over 20 years, I have been advocating for greater inclusion of patients’ perspectives of their disease into the outcomes of clinical trials, into the methods for quality assessment/improvement, and as a basis for shared medical decision making. I have developed disease-specific measures for coronary artery disease, heart failure, and peripheral artery disease.1–3 Although some may say this perspective is self-serving, I think I have gained important insights into the barriers of health status assessments and wish to articulate the challenges I see. Patient-reported outcomes (PROs) quantify patients’ perspectives about the frequency and severity of their symptoms, how their disease impacts their functioning, and the degree to which it limits their quality of life. Over the past several decades, numerous PROs, both generic and disease-specific, have been created, and the methodology for creating such measures has become increasingly codified. A PRO should be valid, reproducible over time in stable patients, and sensitive to clinical changes when they occur.4 Accordingly, PROs can be selected for a variety of conditions that are not only valid, reliable, sensitive to changes in disease status (or treatment), but also prognostic of clinical events, costs, and mortality. Moreover, they are probably the best assessment of the impact of a disease on patients’ health status and are far more reproducible than clinician-reported outcomes, such as the New York Heart Association (NYHA) or the Canadian Cardiovascular Society Classification.5,6 Yet, despite over a decade of calls for these measures to be included in routine clinical care, they are seldom used.7 In November 2013, the Patient-Centered Outcomes Research Institute held a 2-day conference in which multiple healthcare stakeholders assembled to discuss the importance of including PROs in electronic health records and clinical care. Numerous …
Lighting Two Candles With One Flame: An Unaided Human Identification Protocol With Security Beyond Conventional Limit

Designing an efficient protocol for avoiding the threat of recording based attack in presence of a powerful eavesdropper remains a challenge for more than two decades. During authentication, the absence of any secure link between the prover and verifier makes things even more vulnerable as, after observing a threshold challenge-response pair, users' secret may easily get derived due to information leakage. Existing literature only present new methodologies with ensuring superior aspects over previous ones, while ignoring the aspects on which their proposed schemes cope poorly. Unsurprisingly, most of them are far from satisfactory - either are found far from usable or lack of security features. To overcome this issue, we first introduce the concept of "leakage control" which puts a bar on the natural information leakage rate and greatly helps in increasing both the usability and security standards. Not just prevention, but also, by introducing the threat detection strategy (based on the concept of honeyword), our scheme "lights two candles". It not only eliminates the long terms security and usability conflict under the practical scenario, but along with threat detection from the client side, it is capable of protecting the secret at the server side under the distributed framework, and thus, guaranteeing security beyond the conventional limit.
Materials and methods Strains and growth conditions

The isoprenoid farnesol was previously shown to induce morphological features characteristic of apoptosis in the filamentous fungus Aspergillus nidulans. This study demonstrates that under similar liquid media growth conditions, farnesol also triggers apoptosis in the plant pathogenic fungus Fusarium graminearum. However, unlike A. nidulans, F. graminearum spores treated with farnesol exhibited altered germination patterns and most (460%) lysed upon prolonged exposure. Given the economic importance of F. graminearum as a pathogen of small grains, this study proposes that farnesol may have potential value as an antifungal compound.
Rethinking Old Age: Theorising the Fourth Age

1. The Idea of a Fourth Age 2. The Shadow of Long-term Care 3. Demographic and Epidemiological Aspects of the Fourth Age 4. Frailty and the Fourth Age 5. Abjection and the Fourth Age 6. Care and the Moral Identity of the Fourth Age 7. Bridges and Barriers between the Third and the Fourth Age 8. Fashioning a Future for Fourth Age Studies
Sepsis a Citrobacter en el lactante

En el desempefio diario de nuestra labor en la Unidad de Lactantes del Servicio de Pediatria del Hospital Sotero del Rio, nos llamo la atencion la aparicion en forma mas que ocasional de Hemocultivos positivos a Citrobacter, en cuadros clinicos que se com-portaban en todo con las caracteristicas des-critas en la Septicemia del Lactante. (1, 2, 3, 4, 5, 6, 7 y 8). El hecho de ser este germen raramente invocado como causante de sepsis, la falta casi absoluta de bibliografia nacional y la gravedad de los pacientes (2, 4, 6 y 8) nos llevo a realizar un estudio de los casos des-critos en los ultimos 15 meses en el Servicio, con el objeto de describir el cuadro y tenta-tivamente aventurar algunas conclusiones que pudieran ser utiles en el manejo de es-tos ninos. El Citrobacter es una forma de bacilo gram negativo, cuyas caracteristicas morfo-logicas y bioquimicas lo colocan dentro de la familia de los enterobacterias (fermenta­tion de la glucosa). Si bien corresponde a un genero bacteriano fue clasificado en un comienzo con el antiguo grupo Betbeseda y el genero Arizona, en un grupo de obser­vation. Son germenes de alta resistencia en el medio ambiente (9), cuyo habitat normal es el suelo, aguas servidas, e intestino de algu-nos animales. Su poder patogeno para el hombre ha sido discutido, aun cuando sus caracteristicas de enterobacteria lo coloca-rian dentro de los potencialmente patoge-nos. Suelen ser entonces agentes de sindro-mes diarreicos y otros (sepsis, meningitis,
Stock prediction: Integrating text mining approach using real-time news

Mining textual documents and time series concurrently, such as predicting the movements of stock prices based on news articles, is an emerging topic in data mining society nowadays. Previous research has already suggested that the relationship between news articles and stock prices do exist. However, all of the existing approaches are concerning in mining single time series only. The interrelationships among different stocks are not well-addressed. Mining multiple time series concurrently is not only more informative but also far more challenging. Research in such a direction is lacking. In this paper, we try to explore such an opportunity and propose a systematic framework for mining multiple time series based on Efficient Market Hypothesis.
xpression of the avian-specific toll-like receptor 15 in chicken eterophils is mediated by Gram-negative and Gram-positive acteria , but not TLR agonists essica

Toll-like receptors (TLRs) are a critical component of the innate immune response of mammalian and avian species. While most mammalian TLRs have been well characterized, the chicken-specific TLR15 has not been extensively studied. We recently demonstrated that TLR15 is differentially expressed between Salmonella-susceptible-and-resistant chickens, indicating a potential role in the innate immune response to infection with Salmonella. The aim of the present study was to gain better insight into the nature of the ligand for TLR15 by characterizing gene expression patterns of TLR15 by heterophils in response to numerous bacterial-derived TLR agonists LPS, flagellin, CpG oligodeoxynucleotides, lipotechoic acid (LTA), peptidoglycan (PGN), and Pam3CSK4 (PAM), stimulation with live Salmonella enterica serovar Enteritidis (SE-used as a positive control), chicken isolates of Escherichia coli (EC) and Enterococcus gallinarum (EG), the equine-specific pathogen Rhodococcus equi, and stimulation with heat-killed, and formalin-killed SE, EC, and EG. TLR15 expression increased significantly in response to stimulation with live, heat-killed and formalin-killed SE, EC, and EG, but was unaffected by stimulation with known TLR agonists and R. equi. Overall, these observations demonstrate that the individual TLR agonists are not the ligand for TLR15, and that TLR15 recognizes a unique, non-secreted, heat-stabile component of both Gramnegative and Gram-positive bacteria commonly found in and/or capable of causing disease
Exercise and Insulin: Convergence or Divergence at AS160 and TBC1D1?

Akt substrate of 160 kDa (called AS160 or TBC1D4) and TBC1D1, Rab GTPase-activating proteins that regulate glucose transport, become phosphorylated with exercise or insulin stimulation. Evidence suggests that this convergence may prove to be imperfect, and each stimulus will produce a unique phosphosignature, providing a plausible mechanism for their apparently unique and overlapping roles in exercise- and insulin-stimulated glucose transport.