Miracle-dz/UniFAR-FTUs huggingface dataset:
Internal Marketing and Organization Effectiveness on the Hospitals

Lately there is an increasing recognition about the significance of marketing activity towards the internal staff of a company as a group of customer. However, there has been little study on the marketing towards the internal staff of Hospitals. This study aims to provide basic information enabling the planning and implementation of internal marketing of hospitals by illuminating the impact of it on the management of staff. The conclusion of the study shows that the internal marketing and organization effectiveness, it was revealed that the higher the degree of recognition on the working environment, regulation on leave, participation into decision-making, education in the sphere of internal marketing, the higher the organization effectiveness, and that there is no meaningful association of compensation with the organization effectiveness.
Dry Filmpackage for Systemin Packagemolding Process

The stability of packages to protect a MEMS device against molding conditions is simulated and experimentally verified. A finite element method is used to predict the displacement of the cover of the package under influence of molding temperature and pressure. The model is verified using all organic packages of two different materials: ConforMask of Rohm-Haas and TMMF of Tokyo Ohka Kogyo Co. Ltd. The packages are made on wafer scale with a simple two layer dry film process. The process is inexpensive and compatible with CMOS processing. The experimental results were in good agreement with the modeling: the TMMF package (with relatively high Young modulus) withstands the molding pressure.
[Transfer of cDNAs of platelet factor 4 and N-truncated peptide inhibits solid tumor growth in vivo].

OBJECTIVE Determine the anti-tumor angiogenic effect of PF4 and p17 - 70 using virally mediated gene transfer. METHODS Full-length PF4 cDNA and p17 - 70 cDNA were cloned into retroviral vector (pLXSN). KB was incubated with the supernatant of transfected PA317. PCR, RT-PCR and Western blotting analysis was used to determine the integration and expression of foreign gene. By MTT method the effects of the supernatants of PA317-PF4s and KB-PF4s on the proliferation of human umbilical vein endothelial cells (HUVEC) were studied. Tumorigenecity of KB-PF4 and KBp17 - 70 cells was assayed with xenograft tumor growth in isogenous nude mice by examining the growth rate of xenograft, survival, and histochemistry of xenograft tumor. RESULTS Recombinant PF4 and p17 - 70 were able to inhibit selectively HUVEC proliferation. Animal survival was significantly prolonged. Furthermore, p17 - 70 significantly prolonged animal survival compared with PF4 group (P < 0.05). CONCLUSION Transduction of p17 - 70 inhibits solid tumor growth through an anti-angiogensis mechanism. Targeted anti-angiogenesis, using retroviral-mediated PF4 gene transfer, especially p17 - 70 represents a promising strategy for cancer gene therapy.
Design on H ∞-filtering for discrete-time switched delay systems

This article is concerned with the delay-dependent H ∞-filtering problem for discrete-time switched systems with a state delay. By using the switched Lyapunov functional method and choosing a new Lyapunov–Krasovskii functional, and, furthermore, utilising the linearisation technique, sufficient conditions on the existence of a desired filter are formulated as strict linear matrix inequalities. Neither model transformation nor the bounding technique for cross-terms is involved. A numerical example is provided to illustrate the effectiveness of the proposed method.
Estradiol induces physical association of neuronal nitric oxide synthase with NMDA receptor and promotes nitric oxide formation via estrogen receptor activation in primary neuronal cultures

Estrogens and nitric oxide (NO) exert wide‐ranging effects on brain function. Recent evidence suggested that one important mechanism for the regulation of NO production may reside in the differential coupling of the calcium‐activated neuronal NO synthase (nNOS) to glutamate NMDA receptor channels harboring NR2B subunits by the scaffolding protein post‐synaptic density‐95 (PSD‐95), and that estrogens promote the formation of this ternary complex. Here, we demonstrate that 30‐min estradiol‐treatment triggers the production of NO by physically and functionally coupling NMDA receptors to nNOS in primary neurons of the rat preoptic region in vitro. The ability of estradiol to activate neuronal NO signaling in preoptic neurons and to promote changes in protein‐protein interactions is blocked by ICI 182,780, an estrogen receptor antagonist. In addition, blockade of NMDA receptor NR2B subunit activity with ifenprodil or disruption of PSD‐95 synthesis in preoptic neurons by treatment with an anti‐sense oligodeoxynucleotide inhibited the estradiol‐promoted stimulation of NO release in cultured preoptic neurons. Thus, estrogen receptor‐mediated stimulation of the nNOS/PSD‐95/NMDA receptor complex assembly is likely to be a critical component of the signaling process by which estradiol facilitates coupling of glutamatergic fluxes for NO production in neurons.
Longevity and the life‐cycle of management buy‐outs

The longevity debate about buy-outs has hitherto been restricted. By focusing on large highly leveraged transactions, existing research has taken only a partial view of how long buy-outs last and the factors influencing longevity. This paper develops and tests hypotheses concerning the influences on buy-out longevity across the whole spectrum of management buy-out applications. Both quantitative and case study evidence from the U. K. is presented. A heterogeneity view of buy-outs is supported. Tests using quantitative data show that earlier exit is associated with larger buy-outs, and buy-outs arising on privatization from the public sector and from non-U. K. parents. Case study evidence principally supports hypotheses that earlier exit is associated with financing institutions being in a relatively stronger position than management and with more rapidly changing market conditions for the firm.
NK cells in pregnant patients with SLE : a preliminary study

NK cells are a subtype of mononuclear cells morphologically distinct of lymphocytes B and T due to its increased granular density. NK cells participate in immunoregulation, haematopoiesis, reproduction and neuroendocrine interactions. Also play significant role in host defense against certain microorganisms, in part through their ability to secrete cytokines, such as IFN-γ, TNF, and GM-CSF,1 among others.2 They are capable of producing cytokines, pro and antiinflammatory, and lead to death of target cells by apoptosis. NK cells in pregnant patients with SLE: a preliminary study
The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite

SUMMARY The metabolite 2-oxoglutarate (also known as α-ketoglutarate, 2-ketoglutaric acid, or oxoglutaric acid) lies at the intersection between the carbon and nitrogen metabolic pathways. This compound is a key intermediate of one of the most fundamental biochemical pathways in carbon metabolism, the tricarboxylic acid (TCA) cycle. In addition, 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Experimental data support the conclusion that intracellular levels of 2-oxoglutarate fluctuate according to nitrogen and carbon availability. This review summarizes how nature has capitalized on the ability of 2-oxoglutarate to reflect cellular nutritional status through evolution of a variety of 2-oxoglutarate-sensing regulatory proteins. The number of metabolic pathways known to be regulated by 2-oxoglutarate levels has increased significantly in recent years. The signaling properties of 2-oxoglutarate are highlighted by the fact that this metabolite regulates the synthesis of the well-established master signaling molecule, cyclic AMP (cAMP), in Escherichia coli.
The Self in Psychoanalytic Theory

LTERNATIVE PSYCHOLOGICALTHEORIES of the self have typA ically brought with them accompanying changes in psychoanalytic theory and practice more significant than the suggested change in the role of the self. These changes, as in the most currently discussed of such new theories, which takes for itself the title “the psychology of the self’ (Kohut, 1971, 1977), offer not new paradigms within psychoanalysis, but alternative psychoanalytic theories of mental functioning. What is left, for example, of psychoanalysis when an analyst judges a patient to be an instance of “Tragic Man,’’ by far more common in this view than “Guilty Man,” resulting from a psychic deficit brought about by parental failure from the beginning? The psychoanalytic aim which follows and the nature of the psychoanalytic process to achieve it bear no resemblance to psychoanalytic understanding or treatment as we know it. There are no longer unconscious conflicts to be understood and an analytic stance to reach them, but a corrective emotional experience-not called that-to bring the patient up again as he was not brought up before. The same leaders (Kohut, 1971, pp. 290-292) and the same audience spiritedly reject Alexander’s related treatment of years
Joint Recognition and Linking of Fine-Grained Locations from Tweets

Many users casually reveal their locations such as restaurants, landmarks, and shops in their tweets. Recognizing such fine-grained locations from tweets and then linking the location mentions to well-defined location profiles (e.g., with formal name, detailed address, and geo-coordinates etc.) offer a tremendous opportunity for many applications. Different from existing solutions which perform location recognition and linking as two sub-tasks sequentially in a pipeline setting, in this paper, we propose a novel joint framework to perform location recognition and location linking simultaneously in a joint search space. We formulate this end-to-end location linking problem as a structured prediction problem and propose a beam-search based algorithm. Based on the concept of multi-view learning, we further enable the algorithm to learn from unlabeled data to alleviate the dearth of labeled data. Extensive experiments are conducted to recognize locations mentioned in tweets and link them to location profiles in Foursquare. Experimental results show that the proposed joint learning algorithm outperforms the state-of-the-art solutions, and learning from unlabeled data improves both the recognition and linking accuracy.
Delay-aware cooperative multipoint transmission with backhaul limitation in cloud-RAN

Driven by the surging mobile data traffic demands, the cloud radio access network (Cloud-RAN) of small cells has attracted intense interest in both academia and industry. In practice, the capacity-limited backhaul may eventually restrict the performance potential of cooperative multipoint transmission in Cloud-RAN. In this paper, we consider the delay-aware cooperative beamforming control for delay-sensitive traffic with limited backhaul data transfer in Cloud-RAN of small cells. Followed by the proposed simple threshold-based MS-centric cooperative clustering scheme, we formulate the delay-aware cooperative beamforming control problem as an infinite horizon average cost Markov decision process (MDP) and introduce the discrete time Bellman equation which embraces both the queue state information (QSI) and channel state information (CSI). To tackle with the emerging slow convergence of value functions and curse of dimensionality, the continuous time Bellman equation is derived and the suboptimal solution is obtained using the linear approximation of value functions. Since the formulated problem is non-convex, we derive the conservative reformulation of it and further transform it into convex problem using semidefinite relaxation (SDR) technique. Finally, an alternating optimization algorithm is proposed to effectively solve the SDR problem. Simulation results validate the performance gain of the proposed delay-aware cooperative beamforming control with limited backhaul consumption.
Use of host population reduction to control wildlife infection: rabbits and paratuberculosis

SUMMARY Reduction in wildlife populations is a common method for the control of livestock infections which have wildlife hosts, but its success is dependent on the characteristics of the infection itself, as well as on the spatial and social structure of the wildlife host. Paratuberculosis (Mycobacterium avium subsp. paratuberculosis; Map) is a widespread and difficult infection to control in livestock populations and also has possible links to Crohn's disease in humans. Rabbits have recently been identified as a key wildlife species in terms of paratuberculosis persistence in the environment and risk to the wider host community, including cattle. Here we use a spatially explicit stochastic simulation model of Map dynamics in rabbit populations to quantify the effects of rabbit population control on infection persistence. The model parameters were estimated from empirical studies of rabbit population dynamics and rabbit-to-rabbit routes of Map transmission. Three rabbit control strategies were compared: single unrepeated population reductions based on removing individual animals; single unrepeated population reductions based on removal of entire social groups; and repeated annual population reductions based on removing individual animals. Unrealistically high rabbit culls (>95% population reduction) are needed if infection is to be eradicated from local rabbit populations with a single one-off population reduction event, either of individuals or social groups. Repeated annual culls are more effective at reducing the prevalence of infection in rabbit populations and eradicating infection. However, annual population reductions of >40% are required over extended periods of time (many years). Thus, using an approach which is both highly conservative and parsimonious with respect to estimating lower bounds on the time to eradicate the infection, we find that Map is extremely persistent in rabbit populations and requires significant and prolonged effort to achieve control.
"Elikä toimintahan ei liikahda mihinkään ellei sitä johdeta." : Päivähoidon tulevaisuus strategisen johtamisen näkökulmasta

Tampereen ammattikorkeakoulu Tampere University of Applied Sciences Master’s Degree Programme in Development and Management of Health Care and Social Services BJÖRKMAN, NETTA & TÖRNSTRÖM, TERHI: “There is no development unless the operation is being managed. ” The future of children’s day care from the perspective of strategic management. Master’s Thesis 81 pages, 5 appendix pages June 2011 _______________________________________________________________ The purpose of this thesis was to find out what kind of future children’s day care and its management have from the management’s point of view in a big city and in a medium-size municipality. The theoretical underpinnings were strategic management, Balanced Scorecard and children’s day care as a work environment. This qualitative study was executed by using focused interview. The interviewees were three upper management level persons in children’s day care in a big city and three in a medium-size municipality, the total amount of the interviewees being six. The themes of the focused interviews consisted of the four perspectives in SWOT Analysis’s: strengths, weaknesses, opportunities and threats of children’s day care in ten years ́ time, their effects from the management’s point of view, categorized by Balanced Scorecard: learning, economy, processes and client orientation and their role in the organization’s strategic planning at the moment. The results of the thesis were analyzed by data-driven content analysis. This thesis includes a development part as an appendix, which has an example of taking strategy into action in a form of Balanced Scorecard. As the key results of the study emerged the influences of economy on children’s day care and its management, regional collaboration, personnel and personnel management issues and the possible upcoming law on children’s day care, and the effects of possible reconstructing of the administrative sector. The results also highlight client orientation. _______________________________________________________________
Piezoelectric Nanopositioning Control Using Second-Order Discrete-Time Terminal Sliding-Mode Strategy

This paper presents the design of a novel second-order discrete-time terminal sliding-mode control (2-DTSMC) strategy and its application to motion tracking control of a piezoelectric nanopositioning system, which possesses a high-order plant model. The 2-DTSMC strategy is established based on the output feedback only, which eliminates the use of a state observer and facilitates an easy realization. Theoretical analysis proves that the quasi-sliding mode is reached in finite time along with high accuracy of the output tracking. The effectiveness of the proposed control scheme is validated through comparative investigations. Experimental results show that the 2-DTSMC strategy is superior to traditional discrete-time sliding-mode control (DSMC), second-order DSMC, and DTSMC algorithms in terms of motion tracking accuracy, which demonstrates the efficiency of the reported 2-DTSMC scheme with a second-order nonlinear sliding surface.
Research on Theory and Practice of Large-Scale Sports Event’s Legal Regulation——Taking Xiamen International Marathon as an Example

Xiamen marathon,as a public product and service provided by city government,is necessary and available to establish and complete the legal regulation related in order to adapt to the development of market-orientation,socialization and legalization.This paper studies the government’s principal status,legal liability and supplying model about the match on theory and operation’s level,and propose three issues which are legislation,law-enforcement and law-abiding.To explore the selection on legal regulation of Xiamen marathon and the general theory and significance of the legal regulation; the research covers the organization,rights and profits in the match,as well as certain legal regulation problems as infringement and risk-aversion.On the basis of above studies,the research proposes advices on the following three issues as match system-reformation,establishment of legal regulation and improvement of judicial system.
Trends in racial disparities for injured patients admitted to trauma centers.

OBJECTIVE To determine whether outcome disparities between black and white trauma patients have decreased over the last 10 years. DATA SOURCE Pennsylvania Trauma Outcome Study. STUDY DESIGN We performed an observational cohort study on 191,887 patients admitted to 28 Level 1 and Level II trauma centers. The main outcomes of interest were (1) death, (2) death or major complication, and (3) failure-to-rescue. Hospitals were categorized according to the proportion of black patients. Multivariate regression models were used to estimate trends in racial disparities and to assess whether the source of racial disparities was within or between hospitals. PRINCIPAL FINDINGS Trauma patients admitted to hospitals with high concentrations of blacks (>20 percent) had a 45 percent higher odds of death (adj OR: 1.45, 95 percent CI: 1.09-1.92) and a 73 percent higher odds of death or major complication (adj OR: 1.73, 95 percent CI: 1.42-2.11) compared with patients admitted to hospitals treating low proportions of blacks. Blacks and whites admitted to the same hospitals had no difference in mortality (adj OR: 1.05, 95 percent CI: 0.87, 1.27) or death or major complications (adj OR: 1.01; 95 percent CI: 0.90, 1.13). The odds of overall mortality, and death or major complications have been reduced by 32 percent (adj OR: 0.68; 95 percent CI: 0.54-0.86) and 28 percent (adj OR: 0.72; 95 percent CI: 0.60-0.85) between 2000 and 2009, respectively. Racial disparities did not change over 10 years. CONCLUSION Despite the overall improvement in outcomes, the gap in quality of care between black and white trauma patients in Pennsylvania has not narrowed over the last 10 years. Racial disparities in trauma are due to the fact that black patients are more likely to be treated in lower quality hospitals compared with whites.
Proteomic analyses of intermediate filaments reveals cytokeratin8 is highly acetylated – implications for colorectal epithelial homeostasis

Butyrate is a critical cancer‐preventive element in the colon milieu whose mechanism of action is unclear, but appears to be mediated through inhibition of histone deacetylases (HDACs) and consequent alterations in global protein acetylation. Cytokeratins (CKs) have roles in cytoskeletal function as components of the intermediate filaments (IFs) and this involves CKs in the regulation of tissue homeostasis of high‐turnover epithelia such as the colon. We used a 2‐D gel/MS analysis to characterise the proteome of IFs, and a novel monitoring‐initiated detection and sequencing (MIDAS) approach to identify acetylation sites on principal proteins. We report that CKs are highly acetylated in a colon cancer cell line, with five acetylation sites characterised on CK8 and a further one on CK18. Acetylation of CK8 is responsive to butyrate. HDAC5 is the deacetylase associated with IFs. These data indicate a novel action of butyrate as a cancer preventive agent. Acetylation of CK8 may be associated with IFs stabilisation and thereby provide a candidate mechanism for the appropriate retention or loss of epithelial cells from the flat mucosa.
Paracetamol effectively reduces prostaglandin E2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase

Epidemiological studies indicate that nonsteroidal anti‐inflammatory drugs (NSAIDs) are neuroprotective, although the mechanisms underlying their beneficial effect remain largely unknown. Given their well‐known adverse effects, which of the NSAIDs is the best for neurodegenerative disease management remains a matter of debate. Paracetamol is a widely used analgesic/antipyretic drug with low peripheral adverse effects, possibly related to its weak activity as inhibitor of peripheral cyclooxygenase (COX), the main target of NSAIDs. As microglia play an important role in CNS inflammation and pathogenesis of neurodegenerative diseases, we investigate the effect of paracetamol on rat microglial cultures. Although less potent than other NSAIDs, (indomethacin ≃ NS‐398 > flurbiprofen ≃ piroxicam > paracetamol ≃ acetylsalicylic acid), paracetamol completely inhibited the synthesis of prostaglandin E2 (PGE2) in lipopolysaccharide‐stimulated microglia, when used at concentrations comparable to therapeutic doses. The drug did not affect the expression of the enzymes involved in PGE2 synthesis, i.e., COX‐1, COX‐2, and microsomal PGE synthase, or the release of the precursor arachidonic acid (AA). Paracetamol inhibited the conversion of exogenous AA, but not PGH2, into PGE2 indicating that the target of the drug is COX activity. Consistently, paracetamol inhibited with similar IC50 the synthesis of PGF2α and thromboxane B2, two other COX metabolites. Finally, none of the NSAIDs affected the productions of nitric oxide and tumor necrosis factorα, two inflammatory mediators released by activated microglia. As paracetamol was reported to inhibit PG synthesis in peripheral macrophages with an IC50 at least three orders of magnitude higher than in microglia, we suggest that this drug represents a good tool for treating brain inflammation without compromising peripheral PG synthesis. © 2003 Wiley‐Liss, Inc.
The Evolution of Large Corporations in Korea

Controversy still looms large both in public and academic circles as to the role of large corporations in sustainable economic growth. In this book, the new-institutional economics perspective is adopted to clarify and answer some of the most critical questions relating to the behaviour of large corporations in Korea, or the chaebol, and the role and impact of institutions on their behaviour.