Miracle-dz/UniFAR-FTUs huggingface dataset:
Self-navigated motion correction using moments of spatial projections in radial MRI

Interest in radial MRI, also known as projection reconstruction (PR) MRI, has increased recently for uses such as fast scanning and undersampled acquisitions. Additionally, PR acquisitions have intrinsic advantages over standard two-dimensional Fourier transform (2DFT) imaging with respect to motion of the imaged object. It is well known that alignment of each spatial domain projection's center of mass (calculated using each projection's 0th and 1st moments) to the center of the field of view corrects shifts caused by in-plane translation. Here we report a previously unrealized ability to determine the in-plane rotational motion of an imaged object using the 2nd moments of the translation-corrected spatial domain projections. The correction requires only the PR data itself and a new projection view angle acquisition time order. The proposed view angle time order allows the acquisition to be "self-navigating" with respect to both in-plane translation and rotation. Image reconstruction using the aligned projections and detected acquisition angles can eliminate or significantly reduce image artifacts due to such motion. We describe the theory of the correction technique and demonstrate its effectiveness using a computer-controlled motion phantom executing 2-D in-plane translations and a customized pulse sequence capable of introducing known in-plane rotational errors.
Progesterone Regulation of Preimplantation Conceptus Growth and Galectin 15 (LGALS15) in the Ovine Uterus1

Abstract Peri-implantation conceptus (embryo/fetus and associated extraembryonic membranes) growth and development are primarily regulated by secretions from the uterus. This study investigated the effects of progesterone on preimplantation conceptus development and endometrial galectin 15 (LGALS15). Ewes received daily injections of either corn oil (CO) vehicle or 25 mg progesterone (P4) from 36 h postmating to hysterectomy. Treatment with P4 increased blastocyst diameter by 220% on Day 9 and advanced time of elongation of blastocysts to a filamentous conceptus on Day 12. Effects of P4 treatment on blastocyst development were blocked by administration of RU486, a progesterone receptor antagonist. Consistent with early elongation of blastocysts, interferon tau (IFNT) protein was about 50-fold greater in uterine flushes from Day 12 in ewes receiving P4 compared with those receiving CO. Expression of cathepsin L (CTSL) and radical S-adenosyl methionine domain containing 2 (RSAD2), both IFNT-stimulated genes, was increased in endometria of Day 12 P4-treated ewes. LGALS15 mRNA, expressed only in the endometrial luminal epithelium and superficial glands, was detected between Days 9 and 12 and was more abundant in ewes receiving P4 than in those receiving CO on both Days 9 and 12. RU486 treatment ablated P4 induction of LGALS15 mRNA in the endometrial epithelia. LGALS15 protein in uterine flushings was not different on Day 9 but tended to be greater in P4-treated ewes than in those receiving CO on Day 12. The advanced development of blastocysts in P4-treated ewes is hypothesized to involve early induction of specific genes in the endometrial epithelia, such as LGALS15, and undoubtedly components of uterine histotroph.
POTENTIAL USE OF GENETICALLY MODIFIED PIGS AS ORGAN DONORS FOR TRANSPLANTATION INTO HUMANS

1. Transplantation is currently viewed as a successful treatment for end‐stage organ failure. Its more widespread use is severely limited by a shortage of human organ donors. This has stimulated the scientific and medical communities to look at the potential use of animals to solve this problem. For a number of reasons, the pig appears to be the preferred species.
Pathway to Artificial Pancreas Systems Revisited: Moving Downstream

Artificial pancreas (AP) systems, a long-sought quest to replicate mechanically islet physiology that is lost in diabetes, are reaching the clinic, and the potential of automating insulin delivery is about to be realized. Significant progress has been made, and the safety and feasibility of AP systems have been demonstrated in the clinical research center and more recently in outpatient “real-world” environments. An iterative road map to AP system development has guided AP research since 2009, but progress in the field indicates that it needs updating. While it is now clear that AP systems are technically feasible, it remains much less certain that they will be widely adopted by clinicians and patients. Ultimately, the true success of AP systems will be defined by successful integration into the diabetes health care system and by the ultimate metric: improved diabetes outcomes.
THE WEDGES BETWEEN PRODUCTIVITY AND MEDIAN COMPENSATION GROWTH

I ncome inequality has grown over the last 30 years or more driven by three dynamics: rising inequality of labor income (wages and compensation), rising inequality of capital income, and an increasing share of income going to capital income rather than labor income. As a consequence, examining market-based incomes one finds that “the top 1 percent of households have secured a very large share of all of the gains in income—59.9 percent of the gains from 1979–2007, while the top 0.1 percent seized an even more disproportionate share: 36 percent. In comparison, only 8.6 percent of income gains have gone to the bottom 90 percent” (Mishel and Bivens 2011).
Outra Economia para a Nova Sociologia Econômica

Este artigo ressalta que as criticas da Nova Sociologia Economica a Economia se dirigem ao neoclassicismo. Portanto, uma interlocucao economia-sociologia deve usar “outra” economia, cujas racionalidades relacionem valores, afetividade ou tradicoes. Esta teoria economica de carater dinâmico enfoca estruturas do mercado, articula estrutura oligopolica e concorrencia dinamicamente, associa historicidade e incerteza do agente. Finalmente, destaca alguns pontos de contato desta economia com a Nova Sociologia Economica compativeis com uma filosofia do mundo social. Como consequencia, pensamos ser esse um esforco para aproximar as ciencias sociais e trabalhando para que a Economia seja de novo assumida como ciencia historica.
Metric Representations of Network Data

Networks are structures that encode relationships between pairs of elements or nodes. However, there is no imposed connection between these relationships, i.e., the relationship between two nodes can be independent of every other one in the network, and need not be defined for every possible pair of nodes. This is not true for metric spaces, where the triangle inequality imposes conditions that must be satisfied by triads of distances in the space, and these distances must be defined for every pair of nodes. In this paper, we study how to project networks into q-metric spaces, a generalization of metric spaces that encompasses a larger class of structured representations. In order to do this, we encode as axioms two intuitively desirable properties of the mentioned projections. We show that there is only one way of projecting networks onto q-metric spaces satisfying these axioms. Moreover, for the special case of (regular) metric spaces, this method boils down to computing the shortest path between every node and, for the case of ultrametric spaces, it coincides with single linkage hierarchical clustering. Furthermore, we show that the projection method satisfies two properties of practical relevance: optimality, which enables its utilization for the efficient estimation of combinatorial optimization problems, and nestedness, which entails consistency of the structure induced when projecting onto different q-metric spaces. Finally, we illustrate how metric projections can be used to efficiently search networks aided by metric trees.
[Microsatellite instability and loss of heterozygosity in squamous cell carcinoma of the head and neck].

OBJECTIVE To identify the frequency of loss of heterozygosity (LOH) and microsatellite instability (MI) in Chinese sample of squamous cell carcinoma of the head and neck (SCCHN). METHODS 18 microsatellite markers were selected and used in the analysis of 30 paired SCCHN for LOH and MI by polymerase chain reaction. RESULTS In 30 cases of SCCHN, LOH was identified in 12 cases (40%) with at least 1 marker. The prevalence rate of LOH was 0 to 21%, much lower than those reported for most markers. 7 out of the 18 markers (D7S480, D7S522, D9S162, D9S168, D9S304, D9S171 and D17S520) were identified as significant (P < 0.05). However there was no statistically significant correlation between the LOH at these loci and the clinical parameters such as pathological types, tumor size and lymph-node metastasis. MI occurred in only 4 patients, but no MI could be observed using the common criteria for defining MI in two or more markers. CONCLUSION The most common LOH at D7S480, D7S522, D9S162, D9S168, D9S304, D9S171 and D17S520 might imply the existence of potential tumor suppressor gene of a subset of SCCHN, while MI might not be a crucial event.
Importance of Literature in Pharmacovigilance: A Review

Pharmacovigilance is to track and detect new adverse drug reactions mainly due to drugs or due to any other chemical substance or similar entity. The knowledge of a drug’s adverse reactions can be increased by various means, including spontaneous reporting, intensive monitoring and literature searching. But, in this review, we discuss how the medical literature plays a crucial role in pharmacovigilance. It is necessary to improve systematic reviews of adverse drug reactions. As literature is one of the vital sources of signal detection, it is essential for pharmaceutical companies to establish pharmacovigilance programs that capitalize on the best available information from multiple data sources. So, it is important to develop a prototype that first reproduces and standardizes search strategies to have a better information retrieval. Marketing-authorization holders (MAH’s) are encouraged to be aware of publications in their local and international journals frequently or according to local regulation and to bring attention to the company safety departments also.
Phylogenetic comparison of the cyanobacterial genera Anabaena and Aphanizomenon.

Morphological analysis and sequencing of the 165 rRNA gene, the spacer region of the ribosomal operon (ITS1) and the rbcLX (RubisCO) region was performed on 26 Anabaena strains and 14 Aphanizomenon strains isolated from several lakes in Denmark, Finland and France. Based on their morphology, Anabaena strains differed from strains of Aphanizomenon: the vegetative cells, heterocysts and akinetes were significantly wider in Anabaena than in Aphanizomenon. Phylogenetic trees based on the 16S rDNA, ITS1 and rbcLX regions showed that the planktic Anabaena strains were not distinguishable from Aphanizomenon strains. The results of the clustering of Anabaena and Aphanizomenon strains based on 16S rDNA sequences showed that these two genera are not monophyletic. Sequence analysis of the 16S rDNA, ITS1-S and rbcLX regions of the planktic Anabaena strains showed that this genus is heterogeneous. In all methods, Anabaena strains that produced different toxic compounds (e.g. anatoxin-a, microcystin and an unknown neurotoxin) were clustered separately from each other but were grouped either with non-toxic Anabaena and/or Aphanizomenon strains. Our data suggest that the planktic Anabaena and Aphanizomenon isolates belong to the same genus, regardless of their morphological differences. Thus, a taxonomic revision of the two genera is required.
Précis de Doing without Concepts*

1. «Concept» en sciences cognitives Dans le premier chapitre de DwC , je m’efforce de caractériser de manière explicite la notion de concept utilisée en sciences cognitives et je propose de contraindre l’utilisation du terme «concept» dans cette discipline. Je propose qu’en sciences cognitives, un concept de x (une classe d’objets, une matière, un type d’événements, etc.) est un ensemble de croyances à propos de x qui est stocké dans notre mémoire à long terme et qui est utilisé par défaut dans les processus cognitifs qui sous-tendent la plupart (ou peut-être toutes) de nos capacités cognitives supérieures lorsque ces processus produisent des
ETİK DURUM ÖLÇEĞİ’NİN GEÇERLİLİK VE GÜVENİRLİK ÇALIŞMASI

Idealizm ve gorecilik olmak uzere iki alt boyuttan olusan Forsyth’nin (1980) Etik Durum Olcegi, (EDO) isletmeden egitim alanina tum dunyada farkli ulke ve kulturlerde yapilan arastirmalarda yaygin olarak kullanilmaktadir. Bu calismada EDO’nun gecerlilik ve guvenirligi toplam 543 lisans ogrencisi uzerine yapilan uygulamayla incelenmistir. Yapi gecerliligini degerlendirmek icin olcegin maddeleri temel bilesenler cozumlemesi yoluyla faktor cozumlemesine tabi tutulmustur. Sonuclar toplam varyansin % 51.07’sini aciklayan iki faktorlu bir yapi ortaya koymustur. Cronbach alfa yontemiyle olculen ic tutarlilik guvenirligi toplam 19 madde icin . 90, idealizm faktoru icin . 92 ve gorecilik faktoru icin . 84 olarak bulunmustur. Sonuc olarak, EDO’nin Turkce formuna iliskin bulgular olcegin gecerli ve guvenilir oldugunu gostermistir.
Validez y robustez y estabilidad en decisión multicriterio: análisis de sensibilidad en el proceso analítico jerárquico

El trabajo aborda el estudio de uno de los topicos que mas interes estan despertando durante los ultimos tiempos en el campo de la decision multicriterio: el Analisis del Comportamiento. A continuacion, conforme a los tres niveles considerados habitualmente en planificacion (estrategico, tactico y operativo), se plantea efectuar este analisis en tres ambitos: Validez de la Aproximacion, Robustez del Modelo y Estabilidad de la Solucion. Cada uno de estos ambitos evaluara, respectivamente, la efectividad, eficacia y eficiencia del proceso de decision seguido. Tras una breve descripcion de algunos de los matices que los distinguen, se presentan los intervalos de estabilidad y se obtienen los. intervalos de estabilidad globales de un juicio en dos ambitos (problemas tipo a: y y). Esta herramienta, utilizada en el analisis de sensibilidad (estabilidad) de las ordenaciones obtenidas con el Proceso Analitico Jerarquico (AHP), sera empleada, bajo el paradigma de la racionalidad procedimental multicriterio, en la deteccion de los hechos diferenciados y pautas de comportamiento, y en la fijacion de caminos de consenso entre los actores implicados en el proceso de toma de decisiones.
Donor-bridge-acceptor energetics determine the distance dependence of electron tunneling in DNA

Electron transfer (ET) processes in DNA are of current interest because of their involvement in oxidative strand cleavage reactions and their relevance to the development of molecular electronics. Two mechanisms have been identified for ET in DNA, a single-step tunneling process and a multistep charge-hopping process. The dynamics of tunneling reactions depend on both the distance between the electron donor and acceptor and the nature of the molecular bridge separating the donor and acceptor. In the case of protein and alkane bridges, the distance dependence is not strongly dependent on the properties of the donor and acceptor. In contrast, we show here that the distance decay of DNA ET rates varies markedly with the energetics of the donor and acceptor relative to the bridge. Specifically, we find that an increase in the energy of the bridge states by 0.25 eV (1 eV = 1.602 × 10−19 J) relative to the donor and acceptor energies for photochemical oxidation of nucleotides, without changing the reaction free energy, results in an increase in the characteristic exponential distance decay constant for the ET rates from 0.71 to 1.1 Å−1. These results show that, in the small tunneling energy gap regime of DNA ET, the distance dependence is not universal; it varies strongly with the tunneling energy gap. These DNA ET reactions fill a “missing link” or transition regime between the large barrier (rapidly decaying) tunneling regime and the (slowly decaying) hopping regime in the general theory of bridge-mediated ET processes.
Schnelle Regelung mit Ausgangsrückführung für Systeme mit Stellgrößenbeschränkungen

Diese Dissertation behandelt die Stabilitatsanalyse und den Entwurf von schnellen, auf einer Ausgangsruckfuhrung basierenden Regelungen fur Systeme mit linearer Dynamik und Stellgrosenbeschrankungen. Letztere stellen die wohl haufigste Nichtlinearitat in realen Regelungssystemen dar. Daruber hinaus konnen oder sollen in den meisten Anwendungen nicht alle Zustande gemessen werden. Eine Regelung mit Ausgangsruckfuhrung verwendet nur die tatsachlich gemessenen Ausgangsgrosen des Systems. Deshalb ist die Fragestellung, wie solche Regelungen unter Berucksichtigung von Stellgrosenbeschrankungen entworfen werden konnen, fur die Praxis relevant. Der Fokus der Arbeit liegt auf Reglern, die auf der Erweiterung einer Zustandsruckfuhrung um einen Beobachter basieren, und auf Reglern, die eine allgemeine dynamische Ausgangsruckfuhrung verwenden. In beiden Fallen werden sowohl sattigende als auch nichtsattigende Regler untersucht. Fur diese Regler wird jeweils ein Verfahren zur Stabilitatsanalyse und, darauf aufbauend, ein Entwurfsverfahren vorgeschlagen. Diese Verfahren basieren, soweit moglich, auf konvexer Optimierung mit Nebenbedingungen in Gestalt von linearen Matrixungleichungen (LMIs). Damit ist ein sehr effizienter, automatisierter Entwurf der Reglerparameter moglich, der anhand von Beispielen demonstriert wird.
Effects of calcium soaps of fatty acids on postpartum reproductive function in beef cows.

Twelve multiparous Simmental cows (584 kg) were used to determine the influence of calcium soaps of fatty acids (CSFA) incorporated in a range supplement on postpartum reproductive characteristics. Cows were assigned randomly to receive a control [C; containing grain sorghum (GS) and soybean meal (SBM)] or CSFA-based (containing Megalac [a source of CSFA], GS, and SBM) supplement. Supplements plus prairie hay were individually fed. Diets were isonitrogenous and met the NEm requirement for heavy-milking beef cows in early lactation. Supplement feeding and daily blood collection began at parturition. Calves were removed permanently from cows at 25 +/- 2 d postpartum. Duration of first postpartum estrous cycles was determined by both visual observations and changes in concentrations of progesterone in serum. Concentrations of LH in serum (15-min intervals for 6 h) were determined 12 h before and 48 and 96 h after calf removal. Concentrations of progesterone and estradiol-17 beta in serum were determined daily. Cows receiving CSFA had higher (P = .06) mean concentrations of LH than those receiving C (1.47 vs 1.12 +/- .13 ng/ml). Concentrations of estradiol-17 beta were lower (P less than .02) and serum progesterone were higher (P less than .02) between d 6 and 8 of the induced cycle in CSFA-fed cows. Plasma cholesterol was greater (P less than .01) in cows fed CSFA although plasma triglyceride concentrations were similar between treatments. (ABSTRACT TRUNCATED AT 250 WORDS)
Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 5. Oseltamivir Carboxylate

ABSTRACT The aim of this study was to determine the biopharmaceutical characteristics of oseltamivir carboxylate (OC) after pulmonary delivery. After OC bolus and intratracheal nebulization (NEB) in rats, blood was collected and bronchoalveolar lavages (BALs) were performed. Epithelial lining fluid (ELF) concentrations were estimated from BAL fluid. The area under the curve (AUC) ratio for ELF to plasma was 842 times higher after NEB than after intravenous (i.v.) administration, indicating that OC nebulization offers a biopharmaceutical advantage over i.v. administration.
Magnetic fields, radicals and cellular activity

ABSTRACT Some effects of low-intensity magnetic fields on the concentration of radicals and their influence on cellular functions are reviewed. These fields have been implicated as a potential modulator of radical recombination rates. Experimental evidence has revealed a tight coupling between cellular function and radical pair chemistry from signaling pathways to damaging oxidative processes. The effects of externally applied magnetic fields on biological systems have been extensively studied, and the observed effects lack sufficient mechanistic understanding. Radical pair chemistry offers a reasonable explanation for some of the molecular effects of low-intensity magnetic fields, and changes in radical concentrations have been observed to modulate specific cellular functions. Applied external magnetic fields have been shown to induce observable cellular changes such as both inhibiting and accelerating cell growth. These and other mechanisms, such as cell membrane potential modulation, are of great interest in cancer research due to the variations between healthy and deleterious cells. Radical concentrations demonstrate similar variations and are indicative of a possible causal relationship. Radicals, therefore, present a possible mechanism for the modulation of cellular functions such as growth or regression by means of applied external magnetic fields.
Impact of neighbor components heating on power transistor electrical behavior

Both reduction in device sizes and enhanced increase in current densities lead to concern about the impact of self-heating effect on device electrical characteristics. Moreover in power transistors applications, devices are connected in parallel, which follows to also consider thermal interaction between devices. In this study a dedicated structure is designed in order to investigate both thermal phenomena and their effect on electrical measurements. Measurements validate a SPICE model associated to the HICUM level 2 version 2 compact model taking into account temperature variation due to self-heating and thermal coupling.
Recomendando Objetos de Aprendizagem a partir das hashtags postadas no Moodle

A pesquisa tem como objetivo o desenvolvimento de um modulo adicional ao Ambiente Virtual de Aprendizagem - AVA Moodle, a partir do conjunto de hashtags atribuidas nas postagens dos foruns, empregando a tecnica de atribuicao de pesos a documentos conhecida na area da Recuperacao de Informacao - IR, permitindo a execucao de um algoritmo para classificacao e ranqueamento de conteudos a partir dos termos mais citados. Esta abordagem baseia-se nos estudos sobre desenvolvimento de sistemas e recursos de midias sociais. Verifica-se no decorrer da pesquisa, que o Sistema de Recomendacao – SR reduz a dispersao dos usuarios, melhorando a interacao com os conteudos ministrados.