Miracle-dz/UniFAR-FTUs huggingface dataset:
Hadoop and MapReduce technology as a solution for Wireless Body Area Networks in e-Health

Wireless Body Area Network is a wireless network of portable computing devices to monitor the state of the human body. The benefit is very important in health care and allows remote monitoring of patients. It is necessary to find solutions for the processing of such sensor data, the growth of the data increases every second. The concept of rapid data growth with large data and variance data types is characteristic of Big Data. In this paper, we were focused on integrating the sensor data into Hbase is to do this we start by simulating the numbers of data generated by the sensor network with NS2, and thereafter we estimate the amount of data for a given period and for the insertion of the generating data in Hbase we use a mass insertion script and in the last step we analyzed the data with an algorithm of data analysis with MapReduce programming for the Internet of objects in the field of health.
[Clinical research on warm acupuncture therapy for pain in postmenopausal osteoporosis].

OBJECTIVE To observe the clinical efficacy on pain in postmenopausal osteoporosis treated with the warm acupuncture therapy and discuss its effect mechanism. METHODS Ninety cases of postmenopausal osteoporosis were randomized into a warm acupuncture group, an electroacupuncture group and a medication group, 30 cases in each group. In the warm acupuncture group and the electroacupuncture group, Dazhu (BL 11), Shenshu (BL 23) and Xuanzhong (GB 39) were selected bilaterally and stimulated with the warm acupuncture and electroacupuncture therapies respectively, once a day for 30 days totally. In the medication group, caltrate-D tablets were prescribed, 600 mg, once a day for 30 days totally. The changes in the bone density T value, visual analogue scale (VAS) score, serum insulin like growth factor 1 (IGF-1), interleukin 6 (IL-6) and tumor necrosis factor (TNF-alpha) were observed before and after treatment in the three groups. RESULTS (1) The bone density T value in the patients of postmenopausal osteoporosis did not change obviously after 30 days treatment with the three therapies; (2) VAS score was all reduced after treatment, in which, the result in the warm acupuncture group was the most obvious (6.73 +/- 0.24 before treatment vs 4.43 +/- 0.26 after treatment). The value after treatment in the warm acupuncture group was different significantly as compared with the electroacupuncture group (5.13 +/- 0.31) and the medication group (5.17 +/- 0.33, both P < 0.05). (3) The level of serum IGF-1 was improved after treatment in the warm acupuncture therapy [(119.5 +/- 20.1) ng/mL before treatment vs (156.5 +/- 23.9) ng/mL after treatment], which was more apparent as compared with the electroacupuncture group [(136.3 +/- 24.5) ng/mL] and the medication group [(127.7 +/- 22.1) ng/mL, all P < 0.05]. Concerning to reducing the levels of IL-6 and TNF-alpha in serum, the results in the warm acupuncture group were superior to the other two groups (all P < 0.05). CONCLUSION The warm acupuncture therapy achieves the significant efficacy on pain in postmenopausal osteoporosis, which could be related to increasing the level of IGF-1, decreasing the levels of IL-6 and TNF-alpha, promoting bone formation and inhibting bone absorption.
Beam Angle Optimization in IMRT using Pattern Search Methods: Initial Mesh-size Considerations

In radiotherapy treatments, the selection of appropriate radiation incidence directions is decisive for the quality of the treatment, both for appropriate tumor coverage and for enhance better organs sparing. However, the beam angle optimization (BAO) problem is still an open problem and, in clinical practice, beam directions continue to be manually selected by the treatment planner in a time-consuming trial and error iterative process. The goal of BAO is to improve the quality of the radiation incidence directions used and, at the same time, release the treatment planner for other tasks. The objective of this paper is to discuss the benefits of using pattern search methods in the optimization of the BAO problem. Pattern search methods are derivative-free optimization methods that require few function value evaluations to progress and converge and have the ability to avoid local entrapment. These two characteristics gathered together make pattern search methods suited to address the BAO problem. Considerations about the initial mesh-size importance and other strategies for a better coverage and exploration of the BAO problem search space will be debated.
A three-phase shunt Active Power Filter with Unified Constant Frequency Integration Control with RLC connection circuit

This paper discusses a Modular Structure Multilevel Inverter (MSMI) with a Unified Constant Frequency Integration Control (UPC) which is used as an Active Power Filter (APF). APF is connected in shunt to the power system in order to sense the non-sinusoidal current drawn by the non-linear load and inject current to the transmission line which compensates the harmonics drawn by the load. This in turn helps having a power factor value close to one at the source side since the source current is forced to follow the source and thus be in phase with it. An APF topology is simulated for different connection parameters and its performance for each case is studied. Finally the results are compared to show that the topology proposed in this paper has a better harmonic reduction.
Dhrystone benchmark: rationale for version 2 and measurement rules

The Dhrystone benchmark program [1] has become a popular benchmark for CPU/compiler performance measurement, in particular in the area of minicomputers, workstations, PC's and microprocesors. It apparently satisfies a need for an easy-to-use integer benchmark; it gives a first performance indication which is more meaningful than MIPS numbers which, m their literal meaning (million instructions per second), cannot be used across different instruction sets (e.g. RISC vs. CISC). With the increasing use of the benchmark, it seems necessary to reconsider the benchmark and to check whether it can still fulfill this function. Version 2 of Dhrystone is the result of such a re-evaluation, it has been made for two reasons:
Assessment of Be1 and Be2 cells in systemic lupus erythematosus indicates elevated interleukin-10 producing CD5+ B cells

Recent studies indicate that normal B cells can be primed to differentiate into two distinct cytokine- secreting effector subsets, Be1 and Be2. The aim of this study was to analyse, for the first time, Be1 and Be2 cells at the single cell level in SLE patients using the recently developed technique of flow cytometry for intracellular cytokines. Peripheral blood mononuclear cells (PBMC) from SLE patients and age- and sex-matched normal controls were cultured for 24 h in the presence or absence of phorbal myristate acetate and ionomycin (PMA=I) or lipopolysaccharide (LPS). The production of type 1 (IFN-g, IL-2) and type 2 (IL-4, IL-5, IL-6, IL-10, IL-13) cytokines by B cells (and IL-10 production by fractionated CD5+ and CD57 B cells) was investigated using an intracellular cytokine staining technique and flow cytometry. In the absence of PMA=I stimulation, the percentage of B cells from SLE patients was significantly lower than those of normal subjects and significantly more SLE B cells spontaneously produced IL-10 than controls. Moreover, CD5+ B cells from SLE patients were enriched for cells with signs of previous in vivo activation and for high levels of IL-10 production. A significant positive correlation was observed between the percentage of IL-10- and IL-6-producing PMA=I-stimulated B cells in SLE patients, but not in controls. There were no significant differences in the production of other cytokines by B cells of SLE patients and normal subjects. In conclusion, a general alteration of type 1 and type 2 cytokine production by B cells is not observed in SLE patients. The role of B cell cytokines in the pathogenesis of SLE appears to be exerted by elevated secretion of in vivo IL-10, which may play an important role in the immune dysregulation observed in SLE patients. Moreover, the cross regulation of IL-10 and IL-6 is disrupted in SLE patients.
A massive MIMO system with space-time block codes

In this paper, a massive Multiple-Input, Multiple-Output (MIMO) system with space-time block codes is studied. We consider a base station equipped with a massive number of antennas and each user having dual antennas. To improve the diversity gain performance of each uplink user, a space-time block code is applied. We derive sufficient conditions for a good code which is as most orthogonal as possible to obtain high rate and full diversity. We further derive lower bounds of the throughput of the massive MIMO system with linear decoders for zero-forcing and minimum mean squared error decoders, respectively. Simulation results are shown to validate the tightness of the bounds of the throughput. The error rate performance is also demonstrated to obtain the diversity gain for each user.
The pathogenicity of behavior and its neuroendocrine mediation: an example from coronary artery disease.

Although it is frequently hypothesized that perturbations of the body's principal axes of neuroendocrine response, especially the sympathetic-adrenomedullary and pituitary-adrenocortical systems, mediate psychosocial influences on disease, evidence directly supporting this hypothesis is sparse at best and, for most disease entities, nonexistent. In this article, we illustrate a research strategy aimed at elucidating the role of behavior in disease pathogenesis by focusing on a single pathologic process--disease of the coronary vasculature--and emphasizing experimental evidence linking such disease to both behavior and sympathoadrenal activation in nonhuman primates. In cynomolgus monkeys, it is found that several psychosocial variables, e.g., social instability, behavioral dominance (in males), and subordination (in females), promote coronary atherogenesis, either independently or in interaction. Animals exhibiting a heightened cardiac responsivity to stress (reactions of probable sympathetic origin) also develop the most extensive coronary lesions and beta-adrenoreceptor blockade prevents the behavioral exacerbation of atherosclerosis. Social stress causes injury to arterial endothelium (also preventable by adrenoreceptor blockade) and, among chronically stressed animals, impairs endothelium-dependent vasomotor responses of the coronary arteries. It is suggested that similar research programs might elucidate the influence of behavior and neuroendocrine factors on the pathogenesis of other disease states and conditions, including susceptibility to infection.
Inhibitory effect of ganglioside on mastoparan‐induced cytotoxicity and degranulation in lipid raft of connective tissue type mast cell

Antihistamine, the most important drug for Hymenoptera stinging, cannot attenuate cytotoxicity and mast cell direct activation by mastoparan that is the most abundant polypeptides in the venoms of social wasps. The aim of this study was to investigate whether gangliosides inhibit the effect of mastoparan on mast cells activation. The degranulation and cytotoxicity in canine cutaneous mastocytoma cells (CM‐MC) were done by measurement of β‐hexosaminidase release and MTT assay. Lipid raft was isolated with discontinuous sucrose gradient centrifuge for the analysis of distribution of Gαq and Gαi protein by western blotting. We found that mastoparan induced the degranulation in (CM‐MC) via direct activation of Gαi and Gαq with a decrease in their amount in lipid raft. Ganglioside GD1a(disialoganglioside) and GM1 (monosialoganglioside) strongly reduced the degranulation and cytotoxicity through stabilizing the structure of lipid raft domain. In addition, mastoparan generated intracellular reactive oxygen species (ROS) independently from cytotoxicity, through arachidonic cascade but not G‐protein activations. Crude wasp venom showed cytotoxicity and induction of the release from CM‐MC, which were potently reduced by gangliosides. We show here that mastoparan activates both Gαi and Gαq protein and that the exogenous ganglioside GD1a and GM1 inhibit the degranulation and cytotoxicity through stabilizing lipid raft. Gangliosides have potentials to be therapeutic tool or clinical prophylaxis for wasp stinging. © 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25:158–168, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20372
Angiopoietin‐like protein 1 expression is related to intermuscular connective tissue and cartilage development

Angptl1, a member of the angiopoietin‐related protein family, is known to regulate angiogenesis, but little is known of its potential role in other processes. To identify the expression pattern and possible role of angptl1 during embryogenesis, we used gene targeting to generate angptl1‐deficient, nLacZ knockin mice. Staining for β‐galactosidase from embryonic day 9.5 to 6 months of age revealed that angptl1 was initially expressed in the paraxial mesoderm. Expression then shifted to intermuscular connective tissue (fascial plane), joint capsules, and perichondrium (laryngo‐trachea, ribs, and long bones), but not the muscles. The vasculature, central and peripheral nervous systems, digestive, respiratory, and other major organ systems did not show any angptl1 expression. This expression pattern suggests that angptl1 is related to development of the connective tissue and cartilage. Lack of phenotype in mutant mice may be due to a functional redundancy from other related factors. Developmental Dynamics 236:2643–2652, 2007. © 2007 Wiley‐Liss, Inc.
The Inferiority of Agriculture in China: Basis,Connotation and Ways of Transformation

The author defines the agricultural inferiority as weak productivity compared with other industries as a result of difficulty in the development of labor division in agriculture.According to this definition,the inferiority is a relative concept,not a basic characteristic of agriculture itself.Therefore,we should neither weaken the basic position of agriculture nor take high-price measures to protect agriculture,but focus on the improvement of agricultural labor division and promotion of agricultural productivity to change the agricultural inferiority.
Hierarchy of Susceptibility of Dendritic Cell Subsets to Infection by Leishmania major: Inverse Relationship to Interleukin-12 Production

ABSTRACT Dendritic cells (DCs) are professional antigen-presenting cells which initiate and regulate T-cell immune responses. Here we show that murine splenic DCs can be ranked on the basis of their ability to phagocytose and harbor the obligately intracellular parasite Leishmania major. CD4+ CD8− DCs are the most permissive host cells for L. major amastigotes, followed by CD4− CD8− DCs; CD4− CD8+ cells are the least permissive. However, the least susceptible CD4− CD8+ DC subset was the best interleukin-12 producer in response to infection. Infection did not induce in any DC subset production of the proinflammatory cytokine gamma interferon and nitric oxide associated with the induction of Th1 responses. The number of parasites phagocytosed by DCs was low, no more than 3 organisms per cell, compared to more than 10 organisms per macrophage. In infected DCs, the parasites are located in a parasitophorous vacuole containing both major histocompatibility complex (MHC) class II and lysosome-associated membrane protein 1 molecules, similar to their location in the infected macrophage. The parasite-driven redistribution of MHC class II to this compartment indicates that infected DCs should be able to present parasite antigen.
Thermal and Reference Noise Analysis of Time-Interleaving SAR and Partial-Interleaving Pipelined-SAR ADCs

This paper analyzes the thermal and reference noises of two types of successive-approximation-register (SAR) analog-to-digital converters (ADCs): the time-interleaving (TI) and the partial-interleaving (PI) Pipelined. The thermal noise is investigated with accurate estimation by deriving closed-form expressions according to the noise equivalent models on different phases. Additionally, the design trade-off between power and noise for two ADC architectures is discussed in detail. On the other hand, the reference noise due to the large switching transient, which significantly degrades the conversion accuracy, is analyzed and verified through behavioral and circuit level simulations of two ADC architectures operating at 500 MS/s for 10-bit resolution. The simulated results show the supremacy of the PI Pipelined-SAR (PS) architecture over the TI-SAR because it exhibits less reference noise sensitivity.
High potential of adhesion to abiotic and biotic materials in fish aquaculture facility by Vibrio alginolyticus strains

Aims: The ability of Vibrio alginolyticus strains isolated from Sparus aurata and Dicentrarchus labrax nursery to adhere to epithelial cell lines (Hep‐2 and Caco‐2), fish mucus and their ability to form a biofilm on different surfaces (glass, polystyrene, polyethylene and polyvinyl‐chloride) was investigated in this study.
Thermal Radiation Effects on the Mixed Convection Stagnation-Point Flow in a Jeffery Fluid

This study describes the mixed convection stagnation point flow and heat transfer of a Jeffery fluid towards a stretching surface. Mathematical formulation is given in the presence of thermal radiation. The Rosseland approximation is used to describe the radiative heat flux. Similarity transformations are employed to reduce the partial differential equations into the ordinary differential equations which are then solved by a homotopy analysis method (HAM). A comparative study is made with the known numerical solutions in a limiting sense and an excellent agreement is noted. The characteristics of involved parameters on the dimensionless velocity and temperature are also examined. It is noticed that the velocity increases with an increase in Deborah number. Further, the temperature is a decreasing function of mixed convection parameter. We further found that for fixed values of other parameters, the local Nusselt number increases by increasing suction parameter and Deborah number.
Interaction with fibronectin regulates cytokine gene expression in human melanoma cells

Our study was aimed at investigating whether interaction of human melanoma cells with the extracellular matrix (ECM) protein fibronectin (FN) could regulate lymphokine gene expression. Serum‐deprived cells (quiescent condition) of a metastatic melanoma cloned line were cultured either on uncoated or on FN‐ or BSA‐coated surfaces. By means of reverse transcriptase‐polymerase chain reaction (RT‐PCR), we analyzed mRNA expression of 4 cytokines—interleukin (IL)‐Iα, IL‐Iβ, IL‐6 and IL‐8—and 9 growth factors—endothelial cell growth factor (ECGF), basic fibroblast growth factor (bFGF), fibroblast growth factor (FGF)‐5, HST, keratinocyte growth factor (KGF), transforming growth factor (TGF)‐α, TGF‐β1, TGF‐β2 and TGF‐β3. When cultured on FN, melanoma cells expressed IL‐Iα and IL‐6 transcripts in addition to IL‐Iβ, IL‐8, ECGF, TGF‐β1, TGF‐β2 and TGF‐β3, already present in quiescent cells. Amplification parameters to achieve semi‐quantitative RT‐PCR were then determined for each detectable factor, thus allowing us to measure a selective enhancement of mRNA levels for IL‐1α, IL‐6, IL‐8 and TGF‐β2 upon interaction with FN by quiescent melanoma cells. This augmented expression was inhibited by an anti‐integrin β1 chain monoclonal antibody (MAb). Moreover, the amounts of IL‐6, IL‐8 and IL‐β produced in the supernatants, as assessed by ELISA, correlated with the corresponding mRNA expression. Extension of this analysis to the other 5 human primary and metastatic melanoma lines confirmed the ability of FN to selectively up‐regulate only IL‐6 and IL‐8 secretion. Our data indicate that FN is able to modulate expression and secretion of a defined subset of lymphokines in human melanoma. © 1996 Wiley‐Liss, Inc.
Seasonal Changes in Immune Response and Parasite Impact on Hosts

Seasonal changes in the impact of parasites on hosts should result in seasonal changes in immune function. Since both ectoparasites and endoparasites time their reproduction to that of their hosts, we can predict that hosts have been selected to show an annual peak in their ability to raise an immune response during the reproductive season. We found large seasonal changes in immune function between the breeding and the nonbreeding season for a sample of temperate bird species. These changes amounted to a decrease in spleen mass from the breeding to the nonbreeding season by on average 18% across 71 species and a seasonal decrease in T‐cell‐mediated immunity by on average 33% across 13 species. These seasonal changes in immune function differed significantly among species. The condition dependence of immune function also differed between the breeding and the nonbreeding season, with individuals in prime condition particularly having greater immune responses during breeding. Analyses of ecological factors associated with interspecific differences in seasonal change of immune function revealed that hole‐nesting species had a larger increase in immune function during the breeding season than did open nesters. Since hole nesters suffer greater reduction in breeding success because of virulent parasites than do open nesters, this seasonal change in immune function is suggested to have arisen as a response to the increased virulence of parasites attacking hole‐nesting birds.
The Neuropsychiatric Rating Schedule: reliability and validity.

OBJECTIVE To evaluate reliability and validity for the Neuropsychiatric Rating Schedule (NPRS) interview designed to permit diagnosis of organic personality syndrome (OPS) or personality change due to a general medical condition (PC). METHOD Subjects from prospective (n = 50) and retrospective (n = 72) studies of traumatic brain injury were aged 6 through 18 years. Parents and children were informants for the NPRS. Convergent and discriminant validity of subtypes of OPS/PC were assessed against standard scales completed by parents and teachers. Interrater reliability data (n = 20), test-retest reliability data (n = 42), as well as sensitivity-to-change data (n = 37) were collected. RESULTS All subtypes of OPS/PC were diagnosed, but apathy and paranoia subtypes were rare. Rating scale data supported convergent validity of OPS/PC subtypes generated with the NPRS. Affective instability, rage/aggression, and inappropriate social judgment were moderately to highly correlated, but apathy and paranoia could be discriminated from each of these subtypes. Interrater agreement for NPRS items was fair to excellent for all but one item (paranoia). Test-retest reliability was fair to good, and sensitivity to change was demonstrated. CONCLUSION The NPRS generated reliable and valid diagnoses of the common subtypes of OPS/PC.