Miracle-dz/UniFAR-FTUs huggingface dataset:
Copper Nanoparticles as Modulators of Apoptosis and Structural Changes in Tissues

Results of research on copper nanoparticles influence on index of readiness to apoptosis and structural changes of liver, spleen, kidney tissues as well as sensomotor cerebral cortex under copper multiple introductions into organism of animals are presented in the article. It is established that copper nanoparticles distribute in organs and tissues of animals and cause specific structural changes. The increase of copper nanoparticles in organism up to toxical threshold (maximum tolerated dose) results in dystrophy and tissue necrosis. Accurate expression enhancement of Caspase 3 in micro-gliocytes (brain macrophages) has been registered seven days after one-fold intramuscular introduction of copper nanoparticles (dose 2 mg/kg of animal body weight), in liver cells - three and seven days after three-fold intramuscular introduction of copper nanoparticles (total dose was 6 mg/kg of animal body weight), in proximal kidney tubules-three hours, one, three and seven days after three-fold intramuscular introduction of copper nanoparticles (with total dose 6 mg/kg of animal body weight), in spleen cells three hours, one, three and seven days after 12-fold intramuscular introduction (with total dose 24 mg/kg of animal body weight). Received data enables us to propose using index of cells readiness to apoptosis defined by Caspase 3 expression as a criterion for copper nanoparticles introduction safety assessment.
Plasma and synovial fluid inflammatory cytokine profiles in primary knee osteoarthritis

Abstract Objective: The objective of this study is to compare inflammatory cytokine levels in primary knee osteoarthritis (OA) patients and healthy controls. Methods: A total of 32 knee OA patients and 14 healthy controls were enrolled. A multiplex immunoassay was utilized for 10 cytokines in plasma and synovial fluid. Results: Plasma IL-2, IL-4, and IL-6 concentrations were significantly greater in knee OA patients than controls. Moreover, both plasma IL-4 and IL-6 were positively correlated with the radiographic severity of knee OA. Conclusions: Plasma IL-4 and IL-6 may serve as biomarkers reflecting the severity of OA.
Design and Simulation of DC-DC Converters

This research paper focuses especially the design and simulation of dc-dc converters. It contains the theoretical derivations and parameters equations with design and examples. Simulation results for buck, boost and buck-boost converters are shown with the chance of different input parameters. In this work we have analyzed the equation of a buck, boost and buck- boost converters and proposed the design components and simulation of these converters. Changing the input parameters like inductance, capacitance and switching frequency in order to observe the changes in output voltage has been added with simulation graph. These parameters and their equations should be well understood before designing buck or boost or buck- boost converters. Simulation procedures in Orcad are also added in this paper. We have achieved performance parameter equations for these three regulators. It was completed the design and investigation of these three converters through mathematical examples and have generated the circuits for simulating buck, boost and buck boost converters. And also have attained different output voltage curve with the change of input parameters. The output graphs for all the converters are well fitted.
Comparing non-linear mathematical models to describe growth of different animals

The main objective of this study was to compare the goodness of fit of five non-linear growth models, i.e. Brody, Gompertz, Logistic, Richards and von Bertalanffy in different animals. It also aimed to evaluate the influence of the shape parameter on the growth curve. To accomplish this task, published growth data of 14 different groups of animals were used and four goodness of fit statistics were adopted: coefficient of determination ( R 2 ), root mean square error ( RMSE ), Akaike information criterion ( AIC ) and Bayesian information criterion ( BIC ). In general, the Richards growth equation provided better fits to experimental data than the other models. However, for some animals, different models exhibited better performance. It was obtained a possible interpretation for the shape parameter, in such a way that can provide useful insights to predict animal growth behavior.
A mitochondrial genome phylogeny of the Neuropterida (lace-wings, alderflies and snakeflies) and their relationship to the other holometabolous insect orders

1 Cameron, S. L. , Sullivan, J., Song, H. , Miller, K. B. & Whiting, M. F. (2009). A mitochondrial genome phylogeny of the Neuropterida (lace-wings, alderflies and snakeflies) and their relationship to the other holometabolous insect orders. — Zoologica Scripta, ** , ***–*** . We present a mitochondrial (mt) genome phylogeny inferring relationships within Neuropterida (lacewings, alderflies and camel flies) and between Neuropterida and other holometabolous insect orders. Whole mt genomes were sequenced for Sialis hamata (Megaloptera: Sialidae), Ditaxis latistyla (Neuroptera: Mantispidae), Mongoloraphidia harmandi (Raphidioptera: Raphidiidae), Macrogyrus oblongus (Coleoptera: Gyrinidae), Rhopaea magnicornis (Coleoptera: Scarabaeidae), and Mordella atrata (Coleoptera: Mordellidae) and compared against representatives of other holometabolous orders in phylogenetic analyses. Additionally, we test the sensitivity of phylogenetic inferences to four analytical approaches: inclusion vs. exclusion of RNA genes, manual vs. algorithmic alignments, arbitrary vs. algorithmic approaches to excluding variable gene regions and how each approach interacts with phylogenetic inference methods (parsimony vs. Bayesian inference). Of these factors, phylogenetic inference method had the most influence on interordinal relationships. Bayesian analyses inferred topologies largely congruent with morphologically-based hypotheses of neuropterid relationships, a monophyletic Neuropterida whose sister group is Coleoptera. In contrast, parsimony analyses failed to support a monophyletic Neuropterida as Raphidioptera was the sister group of the entire Holometabola excluding Hymenoptera, and Neuroptera + Megaloptera is the sister group of Diptera, a relationship which has not previously been proposed based on either molecular or morphological data sets. These differences between analytical methods are due to the high among site rate heterogeneity found in insect mt genomes which is properly modelled by Bayesian methods but results in artifactual relationships under parsimony. Properly analysed, the mt genomic data set presented here is among the first molecular data to support traditional, morphology-based interpretations of relationships between the three neuropterid orders and their grouping with Coleoptera. Corresponding author: Stephen L. Cameron, Australian National Insect Collection, CSIRO Entomology, Canberra, ACT 2601, Australia. E-mail: stephen.cameron@csiro.au Jaron Sullivan, Hojun Song and Michael F. Whiting, Department of Biology, Brigham Young University, Provo, UT 84602, USA Kelly B. Miller, Department of Biology, and Museum of Southwestern Biology, The University of New Mexico, Albuquerque, NM 87131, USA Blackwell Publishing Ltd A mitochondrial genome phylogeny of the Neuropterida (lace-wings, alderflies and snakeflies) and their relationship to the other holometabolous insect orders
Mobile phone based participatory sensing for urban traffics

Current mobile phones are becoming important platforms that serve the ubiquitous sensing and communication needs of people [29, 55]. The sensing and communication modules on mobile phones are usually developed to provide location and context-aware services. Real-time urban traffic conditions are critical to wide populations and serve the needs of many transportation dependent applications. This report presents our experience of building participatory urban traffic informatics systems that exploits the power of bus riders’ mobile phones. In this report, we first present a bus arrival time prediction system based on bus passengers’ participatory sensing. With commodity mobile phones, the bus passengers’ surrounding environmental context is effectively collected and utilized to estimate the bus traveling routes and predict bus arrival time at various bus stops. Buses are intelligently recognized and tracked using environmental signal hints. Following the bus prediction system, we present our experience of building a participatory urban traffic monitoring system that exploits the power of bus riders’ mobile phones. The system takes lightweight sensor hints and collects minimum set of cellular data from the bus riders’ mobile phones. It then turns buses into dummy probes, monitors their travel statuses, and derives the instant traffic map of the city. Unlike previous works that rely on intrusive detection or full cooperation from “probe vehicles”, our approach resorts to the crowd-participation of ordinary bus riders, who are the information source providers and major consumers of the final traffic output. The proposed systems solely rely on the collaborative effort of the participating users and is independent from the bus operating companies, so they can be easily adopted to support universal bus service systems without requesting support from particular bus operating companies. Instead of referring to GPS enabled location information, we resolve to more generally
Real time automobile tracking system with an automated security algorithm

Numerous designs have been proposed in the contemporary times for the objective of tracking of mobile entities. Our work here proposes a novel prototype supplementing the functions of present tracking systems. It deals with the real time tracking of remote modules placed in moving automobiles. These modules comprise of an Arduino Uno board operating in conjunction with a SIM808 module. They obtain the location coordinates of the vehicle and redirect them to the monitoring authority which views them simultaneously on an ingeniously designed tracking website and Google Maps. Additionally an encrypted security algorithm has been presented which automatically establishes the vehicle operator's identity and cautions the authority in the scenario of a possible theft.
Efficient, High Brightness 1030 nm DBR Tapered Diode Lasers With Optimized Lateral Layout

Efficient, high brightness 1030 nm distributed Bragg reflector (DBR) tapered diode lasers with optimized lateral waveguide and grating designs are presented in this paper. The layout changes were carried out in order to enhance the diffraction efficiency of the manufactured DBR gratings and improve the spatial mode filtering for these lasers. In this study, lasers with straight waveguide and grating, straight waveguide and tapered grating, and tapered waveguide and straight grating are compared. The lasers provide an optical output power up to 15.5 W and narrowband emission over the whole power range. Within the studied parameter range, the highest central lobe output power of 10.1 W is obtained for a laser with a tapered grating. The layout comparison also shows that the influence of the applied ridge waveguide injection current density on the central lobe power is significantly different. Here, the lateral design with a tapered grating is the most robust layout. Compared to previous approaches for DBR tapered diode lasers, optimized waveguide and grating designs and their impact on laser performance may help to increase the application potential of such devices.
Effects of calpastatin and-calpain markers in beef cattle on tenderness traits

The objective of this study was to assess the association of single nucleotide polymorphisms (SNP) developed at the calpastatin (CAST) and -calpain (CAPN1) genes with meat tenderness and palatability traits in populations with diverse genetic backgrounds. Three populations were used in the study. One population consisted of Bos taurus that included crossbred animals derived from Hereford, Angus, Red Angus, Limousin, Charolais, Gelbvieh, and Simmental (GPE7; n = 539). Another population consisted of Bos taurus with Bos indicus influence, including crossbred animals from Hereford, Angus, Brangus, Beefmaster, Bonsmara, and Romosinuano (GPE8; n = 580). The third population was Bos indicus and consisted of purebred Brahman (STARS; n = 444). Traits evaluated were meat tenderness measured as Warner-Bratzler shear force (WBSF; kg) at 14 d postmortem, and traits evaluated by trained sensory panels that included tenderness score, juiciness, and flavor intensity. A SNP at the CAST gene had a significant (P < 0.003) effect on WBSF
Cyber Security Education, Qualifications and Training

The rise in significance of cyber security has led to an increase in the range of interesting career paths that can be followed in this area. Inevitably there has also been an explosion in the diversity of available cyber security education, qualifications and training, most of which is targeted at those seeking to engage with this promising job market. In this article, some guidelines are provided on how to select appropriate education, qualifications and training in cyber security, alongside a review of some of the many current offerings and how to differentiate between them. While the focus is on the UK cyber security sector, many of the observations have wider relevance.
Semiconductor Materials Optimization for a TFET Device With Central Nothing Region on Insulator

This paper presents the work regimes of an atypical SOI device. The proposed device belongs to the Tunneling FET class, but the main body is a vacuum cavity. Each layer has a maximum of 10 nm. Firstly, the paper studies the static characteristics of the proposed device by simulations for different semiconductor materials: Si, SiC and Ge, with different doping concentrations, in different bias conditions. Secondly, some key parameters are defined in order to establish the boundary of the different work regimes. The normal work regime is conditioned by the useful tunneling occurrence, maximum transconductance, and current capability, far away from the insulator breakdown that means a non-useful back-gate leakage current. The simulations reveal optimum Semiconductor-Vacuum-Semiconductor structures On Insulator for heavy doped films, thin oxides, and larger band gap materials. An optimum balance is offered by the SiC device with 10 nm thickness on 10 nm insulator with a cavity width of 2 nm.
Expedited design optimization of compact microwave structures using adjoint sensitivities and space mapping

Expedited design optimization of compact microwave structures using adjoint sensitivities and space mapping (SM) is proposed. For the sake of computational efficiency and good generalization capability, we utilize coarse-discretization electromagnetic (EM) simulation models which are suitably corrected using SM. The mapping parameters are evolving together with the design itself (no fully converged SM parameter extraction is executed), which results in a small number of both low- and high-fidelity EM simulations throughout the optimization process. The algorithm is applied to the design of a compact rat-race coupler.
Modelling of a high step up DC — DC converter based on Boost-flyback-switched capacitor

In this paper, a non-isolated high gain boost converter is hybridized with a switched capacitor cell. This modification has enhanced the voltage gain of the converter from the other existing converters. Further, this has encompassed a reduction in voltage stress of the switching device. The steady state analysis with the parameter design has been included in this paper. Again, the design parameters are verified with the simulation study through MATLAB R2012b.
Green RF technologies for 5G networks

By focusing on the co-design of spectral efficiency and energy efficiency, a new network architecture with both higher capacity and lower power consumption than existing networks is proposed. Through the use of a new network topology, green RF techniques using large scale antenna systems and full duplex radio are proposed as a means to reduce network energy consumption while increasing network capacity for future 5G networks.
agnetic tuning of a kinetic energy harvester using variable reluctance

In this paper we present a new technique for tuning the resonant frequency of an energy harvester using a variable reluctance device which changes the strain in a cantilever beam to alter its spring constant. In order for energy harvesting devices to be able to operate reliably in many applications they must be able to generate energy as the input excitation frequency changes. Most harvesters are resonantly tuned mass-spring-damper devices and therefore it is important that their resonant frequency is tuneable during operation. Several mechanical methods have previously been demonstrated for accomplishing this task which operates by altering the stress in a cantilever beam by altering the distance between a fixed tuning magnet and a magnet on the moving cantilever. Here, we demonstrate a new actuation ovable flux guide method for manipulating the stress in a beam. The actuation mechanism alters the magnetic reluctance between the cantilever mounted and the fixed magnet. The investigation has highlighted the importance of the design of the magnetic circuit and choice of materials in order to avoid eddy current damping and asymmetrical forces. The method presented here has demonstrated a maximum tunable frequency range of 11.1 Hz and may be more suitable for microfabrication than the previously reported techniques due ce wh to the reduced tuning for
A New Balanced Scorecard Approach for Quality of Life Measurement in Italian Local Government

This paper suggests to add social indicators to the existing set of indicators already required by the law requires for local government. We did an effort to integrate the present set of indicators and the Social Reporting (a recent methodology that companies use to report what they did for stakeholders) using balanced scorecard’s approach (a management control system that adds new perspectives to financial data) in order to measure the quality of life at local level.
Modeling and design of an integrated sliding-mode buck converter with regulated switching frequency suitable for mobile devices

Mobile applications necessitate nowadays huge digital resources. Power management of digital circuits is based on dynamic strategies to preserve energy. DC/DC converters used to supply the digital core face stringent constraints with respect to load transients. Sliding-mode control is well suited to control buck converters that are subject to high dynamic load and line transients. Fixed frequency sliding-mode control has been experimented. Transient performances or silicon area are negatively affected. A new analog implementation of the sliding-mode control with switching frequency control is presented here. The proposed synchronization scheme does not degrade the intrinsic asynchronous transient performances and is not affected by a significant silicon area penalty. The proposed DC/DC converter is implemented in CMOS 130 nm. The switching frequency is kept constant thanks to the frequency regulation loop. The demonstrator achieves more than 80% efficiency from 3mW to 840mW.
Economic analysis and energy consumption approaches for lighting improvement of government building facilities

This paper discusses the conversion of fluorescent tube lamp to LED tube lamp in terms of economic analysis point of view. This research was conducted for several brands of the lamp, namely Philips fluorescent tube, Goolite LED tube, and Philips LED tube. Each lamp brand totaling five pieces were tested in the workspace at Research Centre for Electrical Power and Mechatronics — Indonesian Institute of Sciences. The methodology of this research is to measure the lumen, voltage, current, and power factor of each type of lamp. Furthermore, an economic analysis of fluorescent and LED tube was carried out by comparing the amount of electricity cost toward the electricity cost savings. The variable of a lifetime, investment cost, and the amount of electric energy consumed are used as electricity saving variable. From the test results, it is obtained that a smaller electric power consumption about 50%, the light of LED tube lamps emit 17.36–33.84% brighter than fluorescent tube lamps. Regarding the cost, although the price of LED tube lamp is 4–6 times higher than fluorescent tube lamp, it gives 48.64–55.87% electricity cost savings. The electricity cost savings for LED tube lamp is due to 50–60% more energy efficient and 2–3 times longer lifetime compared to fluorescent tube lamp. It can be concluded that as a replacement of fluorescent tube lamp, the use of LED tube lamp for lighting in a government building is very profitable.
A comparison of in situ bottom pressure array measurements with GRACE estimates in the Kuroshio Extension

Ocean bottom pressure estimates from Gravity Recovery and Climate Experiment (GRACE) have been validated by comparisons with an array of in situ bottom pressure measurements. The 600 km by 600 km array comprised 46 bottom pressure sensors that were part of the Kuroshio Extension System Study (KESS). Validations in other ocean regions have been limited by available data to pointwise bottom pressure measurements. Spatially‐averaged monthly‐mean bottom pressure over the KESS array is highly correlated with GRACE bottom pressure estimated at the center of the array. The correlations are nearly equally high for three standard choices of spatial smoothing radius applied to GRACE estimates, 300, 500, and 750 km. In contrast, pointwise comparisons between GRACE and individual bottom pressures are high or low in sub‐regions of KESS, depending partially upon the local variance of deep mesoscale eddies whose energetic length scales are shorter than 300 km. KESS is a suitable validation experiment for the GRACE estimates at monthly scales with 300 to 750 km spatial radius of smoothing.
A Hiperatividade do Professor Bombril

Sao Paulo, segunda-feira, sete horas da manha. Pulo da cama. Calca, camisa e sapato. O dia comeca. Oito horas, primeira sala de aula. Introducao a administracao. Alunos de dependencia refazem o curso com “contagiante” entusiasmo. Taylor, padronizacao, homus-economicus. Tempos Modernos. Trabalho de estatistica e leitura de controle de custos que preciso fazer para a pos (sera que vai dar tempo? ). Fim de aula. O tempo passa. E meio dia, ja foram as tres turmas da manha. Sera que vai dar para acabar o trabalho de estatistica? Almoco por peso. “E ai professor, sua materia reprova? ”. “Professor, alem de dar aula voce tambem trabalha? ” Metamorfose: aula da pos-graduacao (nao fiz a leitura previa), o professor vira aluno. O tema interessa, a discussao tambem. O tempo voa. Fim de aula, e preciso correr, o aluno precisa virar professor novamente. Dia tipico, comentarios tipicos, aulas tipicas, livros tipicos. Simples cotidiano da grande maioria dos alunos de mestrado e doutorado em administracao de nosso pais: de um lado para o outro, de uma sala de aula para outra, de transparencia para transparencia. Os papeis invertem-se, transformam-se. O dia acaba. Amanha, cotidiano “todo dia ela faz tudo sempre igual. ”.
Space-frequency coding for the HIPERLAN/2 standard

This paper attempts to provide an evaluation of high performance local area network (HIPERLAN/2), equipped with space-frequency coded transmit diversity. The HIPERLAN/2 physical layer entities with two antennas are simulated for frequency-selective fading channels for the standard's digital modulation schemes of BPSK, QPSK, 16-QAM and 64-QAM. Packet error rate comparisons of HIPERLAN/2 with and without space frequency coding reveal the potential gains and caveats.