Miracle-dz/UniFAR-FTUs huggingface dataset:
Ancestral duplicated DL/CRC orthologs display function on orchid reproductive organ innovation

The orchid flower is renowned for complexity of flower organ morphogenesis and has attracted great interest from scientists. The YABBY genes encode plant-specific transcription factors with important roles in vegetative and reproductive development in seed plants. DROOPING LEAF/CRABS CLAW (DL/CRC) orthologs are involved in reproductive organ development (especially carpels) of angiosperms. Orchid gynostemium (the fused organ of the androecium and gynoecium) and ovule development are unique developmental processes. Understanding the DL/CRC-like genes controlling the developmental program of the gynostemium and ovule could provide accessible information for reproductive organ molecular regulation in orchids. Two DL/CRC-like genes, named PeDL1 and PeDL2, were cloned from Phalaenopsis equestris. The orchid DL/CRC forms a monophyletic clade with two subclades including AshDL, PeDL1 and DcaDL1 in subclade I, and PeDL2 and DcaDL2 in subclade II. The temporal and spatial expression analysis indicated PeDL genes are specifically expressed in the gynostemium and at the early stages of ovule development. Both PeDLs could partially complement an Arabidopsis crc-1 mutant. Transient overexpression of PeDL1 in Phalaenopsis orchids caused abnormal development of ovule and stigmatic cavity of gynostemium. PeDL1, instead of PeDL2, could form a heterodimer with PeCIN8. Paralogue retention and subsequent divergence of the gene sequence of PeDL1 and PeDL2 in P. equestris might result in the differentiation of function and protein behaviors. These results reveal the important roles of PeDLs involved in orchid gynostemium and ovule development and provide new insights for further understanding the molecular mechanisms underlying orchid reproductive organ development.
Características clínicas de los pacientes con diagnóstico de atresia de esófago

Materiales y métodos: se realizó un estudio transversal durante el periodo comprendido entre el1 de enero de 2003 y 31 de diciembre del 2007, la información proveniente de los expedientes clínicos, fue recopilada en una hoja de recolección de datos y luego se transfirió a una base de datos confeccionada en el programa Access, para un posterior análisis por medio del software estadístico Epi Info 3.5. 1.
Modeling of Neutral Red Adsorption on Apple Peel Based Activated Carbon

Neutral red is used in textile industry as dyestuff. Dyestuffs which remain unchanged throughout the process in the wastewater treatment plants have toxic effects. In this study, removal of neutral red dyestuff from aqueous medium of active carbon obtained from apple peel waste was investigated. For this purpose, the apple peel was pretreated into 2 mm pieces. Chemical Activation of apple peel with ZnCl2 was used in activated carbon preparation. The amount of adsorbed material at different temperatures (25, 35, 45°C) and concentrations (100, 150, 200 ppm) was determined. In addition to the linear model, 4 different nonlinear models were used to model the adsorbed material. From these models, the best estimate for all temperature values and concentrations gave the cubic model.
Comparison of computed Tomography and ultrasonography in evaluating causes of obstructive jaundice

Objective: To observe and compare the role of ultrasonography and computed tomography in evaluation of causes of obstructive jaundice. Materials and Methods: A total of 100 patients were enrolled in this cross-sectional study done in Department of Radiodiagnosis and Imaging, Gandhi Medical College, Bhopal. Results: Computed tomography and ultrasonography were able to detect the presence of biliary obstruction in 100% of cases. Liver function tests were altered in all the patients with alkaline phosphatase raise out of proportion to the AST/ALT. The highest incidence of biliary obstruction was found in 61-70 years’ age group with mean (±SD) age of the patient was 62.7 ± 12.64 years. Sensitivity, specificity and accuracy of computed tomography and ultrasonograhy in detecting the various causes of obstructive jaundice were 90.85%, 99.21% ,98.15% and 84.15%, 98.86% and 97% respectively. Conclusions: Computed tomography has a high sensitivity, specificity and accuracy in detecting the causes of biliary obstruction. Considering these attributes, computed tomography can be used as an effective diagnostic modality in cases of obstructive jaundice. Accuracy and specificity for ultrasonography is high in detecting the causes of biliary obstruction with a slightly low sensitivity. Hence, ultrasonography can be used as an effective screening modality in cases of obstructive jaundice.
Exploración de una estrategia alterna para la integración activa del paciente en el tratamiento de la diabetes: investigación en acción participativa, educación y actividad física

In the world, diabetes disease affects about 347 millions of people, according to the World Health Organization, (WHO). In the United States, this disease has increased from 5.6 millions in 1980 to 20.9 in 2011 (Centers for Disease Control, CDC, 2013). Moreover, the Hispanic group has the greatest rate of increase, specially puertorricans. In Puerto Rico, 2011, 13.5% of the adult population was diagnosed with diabetes. The development of cardiovascular and chronic kidney diseases, sometimes prematurely, is the most significant complications of the diabetes. Therefore, exploring alternative strategies that will help in the prevention of diabetes is of utmost importance. Physical activity/exercise can be used for primary and secondary prevention. Clinical investigations have shown the effectiveness of physical activity/exercise interventions in clinical outcomes in diabetics. However, these patients remain living a sedentary lifestyle. In this article, a description of a new strategy model, participatory action research and social marketing, to establish physical/activity as viable tool for the prevention and treatment of diabetes disease is presented, changing the biomedical model of treatment currently used.
Elements of Effective Practice in Patient-Centred Laboratory Medicine

Laboratory medicine is an evidence-based medicine which involves a set of medical diagnosis conducted on tissues, fluids, or other specimens to assist clinical staff and medical doctors in disease diagnosis and patients treatment. Chemical, cytological, haematological, microbiological, histological, and molecularly techniques are employed in the process of acquiring the diagnostic results. Quality assurance of the medical laboratory is regulated and accredited by international standardisation organisations. The whole process of patient-centred laboratory medicine could be described into five stages: screening of diseases, risk identification and stratification, clinical diagnosis, selection of medical treatment by physicians and continuous monitoring of drug efficacy and side effects. It was reported that the pre-analytical process is the major laboratory errors and thus elimination of these errors is critical for maintaining patient-centred laboratory medicine. Advanced development of molecular medicine and automation of clinical system requires development of laboratory medicine while systematic quality management should be maintained for good quality of medical practice. Foreseeably further laboratory medicine may contribute to targeted therapy and personalised management.
Retrospective Analysis of Vaginismus Patients Referred to Psychiatric Outpatient Clinic in a University Hospital

Amac : Bu calismada, vajinismus hastalarinin sosyodemografik ozelliklerini, altta yatan etyolojik faktorleri ve grup terapisinin, vajinismus tedavisine katkisini incelemeyi amacladik. Materyal ve Metod: Bu calismaya, Aralik 2014 ile Agustos 2016 tarihleri arasinda Harran Universitesi Tip Fakultesi psikiyatri poliklinigine gelen ve vajinismus teshisi konan 30 hasta dâhil edilmistir. Bu hastalar, ortalama 5 kisilik gruplar seklinde, vajinismus grup psikoterapisi alan hastalardan olusturulmustur. Hastalarin dosyalari retrospektif olarak incelenerek, sosyodemografik veriler elde edildi. Istatistiksel analiz icin Windows uyumlu IBM SPSS 23.0 (Chicago, ABD) paket programi kullanildi. Veriler, ortalama ± standart sapma (SD) olarak hesaplandi. Bulgular: Calismaya dahil edilen hastalarin ortalama yasi 23,1 ± 4,02 bulundu. Hastalarin 8'i 20 yas alti (% 26,7), 15'i 21-25 yas (% 50), 7'si 26 yas ve uzeri (% 23,3) idi. En genc hasta 17, en yaslisi 31 yasinda idi. Sadece iki hastanin (% 6.7) cocugu vardi. Hastalarin tumu jinekolojik muayeneye gitmislerdi (%100). Calismamizda dis merkezde vajinismus terapisi goren ve tedaviyi yarim birakan 3 hasta bulunmaktadir (%10). Hastalarin 18’i ilkogretim mezunu olup; ev hanimiydi (%60). Geriye kalan 12 hasta ise universite mezunu olup; bir is yerinde calismaktaydi (%40). Calismamizdaki hastalarin hepsi primer vajinismus olup; daha once hic penis penetrasyonu olmamisti (%100). Calismamizda ek bir psikiyatrik hastaligi olan 4 kadin bulunmakta idi (%13,3). Hastalarin ucunun esinde cinsel islev bozuklugu mevcuttu (%10). Calismamiza dâhil edilen hastalarin ortalama evlilik suresi 8,8±9,3 ay olarak bulundu. Sonuc: Vajinismus evliligin bircok yonunu etkileyebileceginden, bu cinsel islev bozuklugunun mumkun oldugu kadar erken tani ve tedavisi buyuk onem tasimaktadir. Klinik gozlemlerimize gore, vajinismus grup psikoterapisi, bireysel psikoterapiye gore belirgin bir sekilde hem daha kolay hem de cok daha kisa surede basariya ulasmistir. Ayrica zamaninda teshis ve etkin tedavi ile, %100’e yakin bir oranda tedavi edilebilen bir hastaliktir.
Prevalence of coronary artery diseases in type 2 diabetic women

Background: There was increasing evidence that gender differences are important in epidemiology, treatment and outcomes of many diseases, relevant for non-communicable diseases.Methods: Study was conducted in Department of General Medicine, GSL Medical College. Patients who were admitted with type 2 diabetes were recruited in the study. Each patient was interviewed to obtain detailed history and examined thoroughly as per predetermined protocol, national diabetes data group and WHO diagnostic criteria was used. Myocardial infarction was diagnosed by convex ST segment elevation in corresponding leads (early) or QS complexes or abnormal Q waves i.e. Q waves of 0.04 seconds or more in width (or) 25% or more of the voltage of the R wave in the same lead or both in the corresponding leads (late) or T wave inversion in the corresponding leads (late). Statistical analyses were done by using SPSS software version 21.0. Chi-square test was used to assess the association between different categorical variables; p<0.05 was considered statistically significant.Results: Out of 250 participants, 97 were diagnosed as coronary artery disease (CAD), maximum between 51-60 years age group; the difference was statistically significant (p<0.05). The association between dyslipidemia and CAD was statistically significant (p<0.05). Out of 188 post-menopausal cases, CAD was diagnosed in 86 cases; out of the 62 non post-menopausal cases, CAD was diagnosed in 11 cases; The difference was statistically significant (p<0.05). Conclusions: In premenopausal women, the prevalence of CHDs are significantly higher when compared to postmenopausal women.
46, XY, t(10;17) (p13;q22 ) Resiprokal translokasyon ve tekrarlayan gebelik kayıpları: Olgu Sunumu

50% of the genetic factors that play a role in the etiology of Recurrent Pregnancy Loss (RPL). Reciprocal translocations are chromosomal rearrangements. Balanced reciprocal translocation carriers produce gametes containing 50% of unstable genetic material, leading to RPL or congenital anomalies. Proband who admitted to Mersin University Hospital Urology Clinic with a history of RPL in his wife. She has four curettage histories due to cessation of embryonic development at 8 weeks. Also they have one healthy child. Cytogenetic analysis was performed after pedigree of the patient who was referred to our laboratory. Proband 46, XY, t (10; 17) (p13; q22) was found to be a balanced reciprocal translocation carrier. There are 606 genes encoded into the protein in the 17q22 a qter region that has been translocated. Some of these are genes that play an important role in embryonic development and cell metabolism such as CDK3 ( Cyclin-Dependent Kinase 3; Cell Division Kinase 3) , GAA (Gluosidase, Alpha, Acid) and GRB2 (Growth Factor Receptor- Bound Protein 2) . If unbalanced genetic material is transferred to the gametes of the probe, the embryo will be monosomic or trisomic for the genes encoded in this region. In this case, embryo development stops and pregnancy results in abortion.
Implementing Reflective Group Work Activities in a Large Chemistry Lab to Support Collaborative Learning

Many classrooms in higher education are becoming increasingly diverse. Diversity is an asset when student interactions are promoted and facilitated by instructors. The challenge is, many times students are grouped together for a collaborative project without attention to or skilled support for the learning and development that can occur through the intercultural collaborative process itself. Instructors often assume this learning happens automatically or organically and does not need to be acted upon explicitly. However, collaboration skills do not come naturally; simply putting students in groups is not enough. When collaboration is facilitated skillfully it benefits all students, especially those from marginalized and historically underserved groups. Here, we enumerate barriers instructors face in supporting groups, describe/share a model, and explore the implementation of this model in a general chemistry lab, which relies heavily on group work. We found that these activities are feasible in a large STEM class, that students participated and found value in them, and that they enhanced students’ content learning and the development of cross-cutting competencies sought by employers. We hope after reading this paper, instructors will recognize the responsibility and opportunity they have in supporting interactions, and have new inspiration and a pathway to do so.
The effect of management system on mortality and other welfare indicators in Pennsylvania dairy herds

The objective of this study was to identify farm characteristics that were associated with cow (Bos taurus) welfare outcomes, including mortality rate, culling by 60 days of lactation, survival to ≥ 6 years of age and ≥ 5th parity (aged cows), somatic cell score, milk yield, and milk composition. Data were collected on housing systems, feeding systems, pasture strategies, bedding type, labour management practices and other farm characteristics in face-to-face interviews with 314 Pennsylvania dairy herd owners where performance records were available. Five herd management systems were identified in the sample: free-stalls with complete confinement (n = 37); free-stalls that allowed outdoor access (n = 76); tie-stalls with complete confinement (n = 52); tie-stalls with outdoor access and that fed a total mixed ration (n = 72); and tie-stalls with outdoor access and that did not feed a total mixed ration (n = 77). Welfare outcomes were evaluated with multivariable linear regression models and marginal means were estimated for herd management system. Tie-stalls that allowed outdoor access and that did not feed total mixed rations had the lowest mortality rate (2.0%), culling in the first 60 days of lactation (5.1%), and the highest proportion of aged cows (13.8%). Those herds also had high lifetime-to-date milk yield, a low proportion of fat-protein inversions, and low somatic cell scores. Free-stalls with complete confinement had significantly higher levels of mortality (8.3%), culling in the first 60 days of lactation (9.7%), and fewer aged cows (6.4%). It was concluded that shifts toward more efficient herd management systems have not benefited cow health and welfare. This suggests that cow welfare has been compromised to facilitate the economic survival of dairy farms.
KEYNOTE-185: a randomized, open-label phase 3 study of pembrolizumab in combination with lenalidomide and low-dose dexamethasone in newly diagnosed and treatment-naive multiple myeloma (MM).

TPS8069Background: Pembrolizumab is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2, leading to antitumor immune response. In the phase 1 KEYNOTE-023 trial of pembrolizumab + lenalidomide and low-dose dexamethasone, the treatment combination had an acceptable safety profile and promising preliminary efficacy in patients with relapsed/refractory MM, supporting further evaluation of pembrolizumab for patients with MM. The randomized, open-label, multicenter, phase 3 KEYNOTE-185 study (NCT02579863) was designed to compare the efficacy and safety of lenalidomide and low-dose dexamethasone (standard of care) with or without pembrolizumab in patients with newly diagnosed and treatment-naive MM. Methods: Eligible patients must be aged ≥ 18 years, have newly diagnosed, treatment-naive active MM with measurable disease and be ineligible for autologous stem cell transplant. Patients are to be randomized 1:1 to receive lenalidomide 25 mg daily on days 1-21 an.
Effects of Hypoxia during Continuous and Intermittent Exercise on Glycaemic Control and Selected Markers of Vascular Function in Type 1 Diabetes

OBJECTIVES The aim of the study was to assess the effect of continuous and intermittent exercise in hypoxia on glycaemic control and selected markers of vascular function in patients with Type 1 diabetes (T1D). METHODS 12 patients suffering from T1D for 12.1±6.0 years and 12 healthy adults performed: continuous exercise (ExC) and intermittent exercise (ExInt) in normoxia and hypoxia (FiO₂=15.1%). Glycaemia and proangiogenic factors concentrations were measured at rest and immediately after exercise. RESULTS T1D patients' glycaemia decreased in response to ExC (p<0.01) and ExInt (p<0.05) under hypoxic conditions. ExInt in normoxia (p<0.05) and hypoxia (p<0.05) reduced HIF-1α in the T1D group. A tendency for vascular endothelial growth factor to increase after ExInt in hypoxia (6.0±3.8 vs. 17.1±13.07 pg/mL) and a proinflammatory cytokine TNF-α level to decrease (33.2±19.1 vs. 25.1±14.4 pg/mL) was found in the same group. CONCLUSIONS Combining exercise with hypoxia may allow more effective short-term glycaemic control in T1D. Intermittent exercise with hypoxia could stabilize the secretion of selected proangiogenic factors and reduce inflammation, potentially leading to improved vascular function.
Economics and the Shop Floor: Reflections of an Octogenarian

In 2000, the Post-Autistic Economics Newsletter began covering the resistance of French students against the “uncontrolled use of mathematics” in their discipline. The students spoke of a “need to liberate economics from its autistic obsession with formal models that have no obvious empirical reference. ” (Post-Autistic Economics Newsletter, issue 3, 27 Nov 2000) In an earlier newsletter they had elaborated, too often the lectures leave no place for reflection. Out of all the approaches to economic questions that exist, generally only one is presented to us. This approach is supposed to explain everything by means of a purely axiomatic process, as if this were THE economic truth. We do not accept this dogmatism. We want a pluralism of approaches, adapted to the complexity of the objects and to the uncertainty surrounding most of the big questions in economics (unemployment, inequalities, the place of financial markets, the advantages and disadvantages of free-trade, globalization, economic development, etc.) (Post-Autistic Economics Newsletter, issue 2, 3 Oct 2000). The students did not object to economics being a science; they just wanted to make it empirically relevant. This search for an empirically relevant science of economics has been a hard slog, for if the effort to show the autistic nature of orthodox nomothetic neoclassical economics has been relatively easy, the search for a praxis relevant alternative has not. I suggest that in looking for empirical relevancy primarily through expansion into the social sciences, post-autistic economists have been looking in the wrong place. For empirical relevance they need to focus on the relationship between economics and the shop floor.
Eight-Milligram Single Dose of Buprenorphine as an Expeditious Treatment for Severe Suicidal Ideation: A Case Report

Introduction: Buprenorphine is used to treat opioid use disorder and pain syndromes. This drug may be a suitable treatment choice for refractory depression, anxiety, self-injurious behaviors, and suicidal ideation. However, it has a signiﬁcant abuse potential, which limits its use in suicidal patients with a history of substance abuse. CaseReport: Inthisreport,wepresentacaseof chronicsuicidalideationduetosubstance-induceddepressivedisorderina25-year-oldmanfromNoorabad,Fars,Iran. Thepatientwassuccessfullytreatedwithan8-mgsingledoseof sublingualbuprenorphinewith minimal probability of diversion or misuse. We observed that 8 mg of buprenorphine exerted a rapid eﬀect on the reduction and cessation of suicidal thoughts and depression. Conclusions: We demonstrated the antisuicidal eﬀectiveness of a single dose of buprenorphine, which can be administered with minimum risk of diversion or misuse for suicidal patients with a history of substance abuse.
Preparation and study on the optical, mechanical, and antibacterial properties of polylactic acid/ZnO/TiO2 shared nanocomposites

In this research, first, ZnO nanorods were synthesized by hydrothermal method and characterized in terms of morphological and structural properties by means of field emission scanning electron microscopy, Fourier transform infrared, and X-ray diffraction techniques. Subsequently, polylactic acid/ZnO, polylactic acid/TiO2, and polylactic acid/ZnO/TiO2 nanocomposites with different percentages of nanoparticles and two different types of ZnO morphologies were prepared and their microstructural, optical, mechanical, hydrolytic degradation, and antibacterial properties were investigated. Field emission scanning electron microscopy results of polylactic acid/ZnO and polylactic acid/TiO2 samples showed a proper dispersion and nanoparticle distribution for low percentages (up to 5 wt%) and increased aggregation for the higher percentages. Besides, a large increase in the aggregation tendency was observed for combined nanoparticles (polylactic acid/ZnO/TiO2 nanocomposites). Results of the tensile test, the UV–Vis absorption tests, and the hydrolytic degradation tests of the samples showed an enhanced mechanical (approximately 55% increase in the presence of 3–5 wt% of nanoparticles) and light absorption and degradation (approximately 85% increase in the presence of 3–10 wt% of nanoparticles) for the polylactic acid by incorporating nanoparticles. It was also observed that, in addition to the quality of dispersion and distribution of nanoparticles in the polymeric matrix, the type of morphology of nanoparticles can contribute to the improvement of these properties. The cylindrical morphology of ZnO played a greater role on improving the polylactic acid mechanical properties compared to the spherical ZnO morphology (approximately 20%). On the contrary, the increased polylactic acid optical properties and degradation with ZnO spherical morphology were more pronounced (approximately 60%). Interestingly, when both ZnO and TiO2 were added, a synergistic effect in the case of UV-shielding and degradation rate and alternatively, a detrimental effect on the mechanical properties were detected. (The polylactic acid optical properties increased by about 17% and its degradation more than doubled.) Furthermore, the antibacterial activity of polylactic acid was investigated against the two Gram-positive Listeria monocytogenes and Gram-negative bacteria Escherichia coli by incorporating nanoparticles. The results indicated that as the nanoparticle percentage increases, the antibacterial activity steadily increases.