Miracle-dz/UniFAR-FTUs huggingface dataset:
QEEG Studies in the Assessment and Treatment of Childhood Disorders

Quantifying EEG measures across age allows the ability to establish parameters of normalcy at any age which can be used as a reference when children exhibit developmental delays in their abilities and/or other atypical and maladaptive behaviors. A review of the current literature on the utilization of QEEG methods to serve as an aid for identifying these children as distinctively different from normal, and in some cases as distinctive from other clinical considerations has been shown to provide a sufficient sensitivity and specificity worthy of consideration as a diagnostic aid in evaluating clinical deviations in development. Furthermore, these same QEEG measures can provide a means of establishing treatment efficacy for the evident brain dysfunctions underlying these childhood disorders.
Additive manufacturing implementation in healthcare systems : a supply chain perspective

Additive Manufacturing (AM), or “3D Printing”, also called the ‘Third Industrial Revolution’, allows companies and individuals to “print-out” solid objects layer-by-layer based on access to 3-dimensional computer data. Several authors have pointed out that AM has the potential to reduce the number of stages in the traditional supply chain and to fundamentally revolutionize manufacturing operations and supply chains. Evidence suggests that AM technology as a driver of supply chain transformation it can achieve precision, speed, affordability, and materials range. Therefore, it has the potential to redesign products with fewer components and to manufacture products near the customers. Production applications of AM technologies can be found mainly in aerospace, automotive, medical, and consumer goods. Although a number of companies are already using AM technologies they face particular difficulties in the implementation process. In particular, studies on AM implementation are disappointingly absent, especially in relation to supply chain. Most studies on supply chain focus mainly on the potential disruptions of AM in distribution/logistics and therefore on location of manufacturing. Hence, an investigation on the key AM implementation factors within the various stages of a supply chain from the selection of raw material-equipment suppliers towards the customers needs to be examined. This study proposes an AM implementation framework on supply chain. It focuses on the healthcare sector and medical device manufacturers. Healthcare organisations must constantly monitor supply chain performance to add value across entire supply chain. AM presents an effective and promising commercial proposition to respond to the increasing healthcare demands in the developing world by providing customized products, which can improve medical care, reduce healthcare costs by decreasing time spent under direct care and improve success rates. It is carried out through a case study research approach combined with background theory on advanced manufacturing systems. Three case studies were conducted to examine the AM implementation process on supply chain. The most significant contribution of the research is the proposed AM implementation framework from a supply chain perspective. At the time of writing this is the first study which examines the AM implementation process on the supply chain of medical device manufacturers. Hence, AM medical device manufacturers can use it as a guide to develop their own implementation plans.
[Validation of the Spanish version of the attention deficit hyperactivity disorder adult screening scale (ASRS v. 1.1): a novel scoring strategy].

INTRODUCTION Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder in the adulthood. It's diagnosis is a complex process in which a screening tool can be useful. AIM To analyze the six-question Adult ADHD Self-Report Scale (ASRS v. 1.1) validity in an outpatient clinical context. SUBJECTS AND METHODS We performed a case-control study, involving 90 patients with ADHD and 90 controls without ADHD. They were outpatient treated in a program for adults ADHD in a hospital. The clinical disorder diagnosis was measured by the Conners Adult ADHD Diagnostic Interview. We analyzed the test accuracy for different ways to score and cut-offs. RESULTS We found the best psychometric characteristics of ASRS v. 1.1 using a quantitative ranking between 0 and 24 points, setting as cut-off 12 points. We observed a sensitivity of 96.7%, specificity 91.1%, positive predictive value 91.6% negative predictive value 96.5%, kappa index 0.88 and area under the curve 0.94 (odds ratio = 297.3; 95% confidence interval = 76.2-1,159). CONCLUSION The ASRS is a valid and useful tool for the adult ADHD screening in the clinical context.
Purification and characterization of a novel thermo stable L-methioninase from Streptomyces sp. DMMMH4 and its evaluation for anticancer activity.

L-methioninase has been purified 2.55-fold from the crude extract of Streptomyces sp. DMMMH4. The purification procedure was carried out by heat treatment and gel filtration on Sephadex G-200 column chromatography. SDS-PAGE electrophoresis showed a migrating protein band molecular mass of 48 kDa. The kinetic properties determined for the purified enzyme displayed optimum activity at 70OC and thermal stability was 70OC for 30 min. The enzyme activity showed maximum activity at pH 6 using acetate buffer 0.05M and was relatively stable across a broad range of pH values (5.5-8 pH). The enzyme strongly inhibited by Cr+2, Fe+2, Ni+2, Cd+2, PMSF, β-mercaptoethanol and SDS while Hg+2,Cu+2 and iodoacetate completely inhibited the enzyme activity at a final concentration of 10mM. The purified enzyme exhibited a Km of 0.7, 0.15 and 0.25 mM for L-methionine, DL-ethionine and L-cystine respectively. Cytotoxicity test demonstrate that enzyme was active against liver HepG2, breast MCF-7, lung A549, prostate PC3 and colon HCT116 cancer cell lines and has negligible toxicity toward a normal melanocyte cell line HFB4 .
Pooled analysis of the accuracy of five cervical cancer screening tests assessed in eleven studies in Africa and India

Cervical cancer is the main cancer among women in sub‐Saharan Africa, India and other parts of the developing world. Evaluation of screening performance of effective, feasible and affordable early detection and management methods is a public health priority. Five screening methods, naked eye visual inspection of the cervix uteri after application of diluted acetic acid (VIA), or Lugol's iodine (VILI) or with a magnifying device (VIAM), the Pap smear and human papillomavirus testing with the high‐risk probe of the Hybrid Capture‐2 assay (HC2), were evaluated in 11 studies in India and Africa. More than 58,000 women, aged 25–64 years, were tested with 2–5 screening tests and outcome verification was done on all women independent of the screen test results. The outcome was presence or absence of cervical intraepithelial neoplasia (CIN) of different degrees or invasive cervical cancer. Verification was based on colposcopy and histological interpretation of colposcopy‐directed biopsies. Negative colposcopy was accepted as a truly negative outcome. VIA showed a sensitivity of 79% (95% CI 73–85%) and 83% (95% CI 77–89%), and a specificity of 85% (95% CI 81–89%) and 84% (95% CI 80–88%) for the outcomes CIN2+ or CIN3+, respectively. VILI was on average 10% more sensitive and equally specific. VIAM showed similar results as VIA. The Pap smear showed lowest sensitivity, even at the lowest cutoff of atypical squamous cells of undetermined significance (57%; 95% CI 38–76%) for CIN2+ but the specificity was rather high (93%; 95% CI 89–97%). The HC2‐assay showed a sensitivity for CIN2+ of 62% (95% CI 56–68%) and a specificity of 94% (95% CI 92–95%). Substantial interstudy variation was observed in the accuracy of the visual screening methods. Accuracy of visual methods and cytology increased over time, whereas performance of HC2 was constant. Results of visual tests and colposcopy were highly correlated. This study was the largest ever done that evaluates the cross‐sectional accuracy of screening tests for cervical cancer precursors in developing countries. The merit of the study was that all screened subjects were submitted to confirmatory investigations avoiding to verification bias. A major finding was the consistently higher sensitivity but equal specificity of VILI compared with VIA. Nevertheless, some caution is warranted in the interpretation of observed accuracy measures, since a certain degree of gold standard misclassification cannot be excluded. Because of the correlation between visual screening tests and colposcopy and a certain degree of over‐diagnosis of apparent CIN2+ by study pathologists, it is possible that both sensitivity and specificity of VIA and VILI were overestimated. Gold standard verification error could also explain the surprisingly low sensitivity of HC2, which contrasts with findings from other studies. © 2008 Wiley‐Liss, Inc.
On tracking control of cooperative hydraulic manipulators

This paper addresses the problem of tracking control of multiple hydraulic manipulators handling a rigid object. We propose a controller that allows two or more hydraulically-actuated robots cooperatively, to move a rigid object along a desired trajectory while sharing the load and maintaining an acceptable internal force on the object. The parasitic effect of friction in the actuators, as well as parametric uncertainties in the manipulators’ dynamics, hydraulic functions and the payload, are compensated through augmentation of the controller by a set of online updating laws. Additionally, an adaptive observer is used along with the controller to avoid the requirement of acceleration feedback, which could be difficult to obtain in practice. Only measurements of joint positions, joint velocities and hydraulic line pressures are required for the implementation of the controller. The tracking error of the control system is proven to converge to zero while the internal force remains bounded. It is further proven that the internal force can be set as close as possible to the desired value through the addition of a simple force feedback loop with an adjustable gain. Both simulation and experimental studies are conducted to clearly illustrate the effectiveness of the developed controller for various tracking tasks. The simulations are carried out using a complete nonlinear model of two multiple-degree-of-freedom industrial hydraulic manipulators handling a rigid object. Experiments are carried out on an available fully-instrumented electro-hydraulic system.
Recent trends in the management of status epilepticus

Status Epilepticus (SE) is a neurologic emergency associated with high morbidity and mortality. The etiology varies among the different age groups, and it has a U-shaped incidence curve, being more common at the extremes of ages. Mortality is rarely due to the status itself, and the outcome depends to a great extent on the underlying etiology and the presence of additional medical conditions. Outcome also depends on the rapidity of diagnosis and initiation of appropriate therapy. Anti-epileptic drug administration in appropriate doses should begin promptly after the suspicion of SE; intra-muscular midazolam and rectal diazepam administered by paramedical staff involved in transporting the patient also has been shown to shorten the duration of SE. Attention should be paid in the initial stages itself to airway patency, adequacy of breathing and ventilation, the circulatory status, securing intravenous access and identifying the underlying cause. The goals of therapy include rapid termination of clinical and electrical ictal activity, prevention of aspiration pneumonia, and treatment of complications in anticipation. Every hospital needs to manage SE on the basis of established protocols, and an early decision regarding artificial ventilation and midazolam or barbiturate anesthesia for refractory SE needs to be taken. With the existing protocols and available drugs, it is generally possible to control seizures and prevent complications and mortality.
Modulation of the Hormone Setting by Rhodococcus fascians Results in Ectopic KNOX Activation in Arabidopsis1[W][OA]

The biotrophic actinomycete Rhodococcus fascians has a profound impact on plant development and a common aspect of the symptomatology is the deformation of infected leaves. In Arabidopsis (Arabidopsis thaliana), the serrated leaf margins formed upon infection resemble the leaf phenotype of transgenic plants with ectopic expression of KNOTTED-like homeobox (KNOX) genes. Through transcript profiling, we demonstrate that class-I KNOX genes are transcribed in symptomatic leaves. Functional analysis revealed that BREVIPEDICELLUS/KNOTTED-LIKE1 and mainly SHOOT MERISTEMLESS were essential for the observed leaf dissection. However, these results also positioned the KNOX genes downstream in the signaling cascade triggered by R. fascians infection. The much faster activation of ARABIDOPSIS RESPONSE REGULATOR5 and the establishment of homeostatic and feedback mechanisms to control cytokinin (CK) levels support the overrepresentation of this hormone in infected plants due to the secretion by the pathogen, thereby placing the CK response high up in the cascade. Hormone measurements show a net decrease of tested CKs, indicating either that secretion by the bacterium and degradation by the plant are in balance, or, as suggested by the strong reaction of 35S:CKX plants, that other CKs are at play. At early time points of the interaction, activation of gibberellin 2-oxidase presumably installs a local hormonal setting favorable for meristematic activity that provokes leaf serrations. The results are discussed in the context of symptom development, evasion of plant defense, and the establishment of a specific niche by R. fascians.
Evidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways.

Cultured human endothelial cells (EC) resist tumor necrosis factor (TNF)-mediated apoptosis. However, the combination of TNF and the protein synthesis inhibitor cycloheximide (CHX) induces apoptosis in up to 50% of EC within 24 hours. TNF + CHX killing is effectively blocked by transfected CrmA protein or treatment with Z-VAD.fmk peptide-both inhibitors of interleukin-1-converting enzyme-like proteases-but not by transfected antiapoptotic proteins Bcl-2, Bcl-XL, or A1. C6-ceramide (cer) can also sensitize EC to TNF-induced apoptosis. TNF + cer killing, which can affect more than 50% of EC, is not effectively inhibited by CrmA or Z-VAD frank, but can be readily blocked by Bcl-2, Bcl-XL, or A1. Both TNF + CHX and TNF+ cer killing are induced by a TNF mutein that only interacts with the type 1 TNF receptor, and both responses can be inhibited by the antiapoptotic protein A20. These data suggest that TNF activates two biochemically separable pathways of EC injury.
A Method for Fast Multi-Exposure Image Fusion

This paper proposes a method for fusing multi-exposed images that can operate on digital cameras or smartphones. The proposed method consists of an automatic exposure bracketing algorithm that determines which exposures to capture and a newly proposed multi-exposure image fusion algorithm. This fusion algorithm attempts to improve the fusion performance on the basis of the recently proposed no-reference image-quality metrics, noting that the exposure change affects the change in the local luminance details, contrast, and colorfulness of a pixel. Experimental results of various sample image sequences show the superiority of the proposed fusion algorithm in terms of both objective and visual evaluations. By using the proposed method, users can capture high-dynamic range images directly on digital cameras or smartphones, without using offline image-processing software.
How blockchain technology can improve the outcomes of clinical trials

This article applies ‘outcome-driven innovation’ methodology, developed by Anthony Ulwick and popularised by Clayton Christensen, to the domain of clinical trials. Data were collected through in-depth, open interviews with doctors, nurses and researchers in the UK, France and Italy. Pain points for key players of the value chain were identified. The findings supported a multi-stakeholder approach to fully exploit the transformative potential of blockchain technology to resolve issues. The research identified a set of opportunities for innovators to improve the way hospitals conduct clinical trials using smart contracts and blockchain technology generally.
Optical Retroreflective Marker Fabricated on Silicon-On-Insulator

Optical retroreflective markers provide a strong return signal when illuminated by a source, resulting in an easy way to localize and identify an object. As current optical retroreflectors are typically bulky, we have investigated the use of the integrated silicon photonics platform to fabricate optical retroreflectors. An optical retroreflective marker with a total field of view (FOV) of about 57° × 4° is shown here. With a limited number of reflectors, a large FOV can then be covered.
An Incremental Method for Solving Convex Finite Min-Max Problems

We introduce a new approach to minimizing a function defined as the pointwise maximum over finitely many convex real functions (next referred to as the component functions), with the aim of working on the basis of incomplete knowledge of the objective function. A descent algorithm is proposed, which need not require at the current point the evaluation of the actual value of the objective function, namely, of all the component functions, thus extending to min-max problems the philosophy of the incremental approaches, widely adopted in the nonlinear least squares literature. Given the nonsmooth nature of the problem, we resort to the well-established machinery of bundle methods. We provide global convergence analysis of our method, and in addition, we study a subgradient aggregation scheme aimed at simplifying the problem of finding a tentative step. This paper is completed by the numerical results obtained on a set of standard test problems.
A Class of Bounded Distributed Control Strategies for Connectivity Preservation in Multi-Agent Systems

This technical note proposes a general class of distributed potential-based control laws with the connectivity preserving property for single-integrator agents. The potential functions are designed in such a way that when an edge in the information flow graph is about to lose connectivity, the gradient of the potential function lies in the direction of that edge, aiming to shrink it. The results are developed for a static information flow graph first, and then are extended to the case of dynamic edge addition. Connectivity preservation for problems involving static leaders is covered as well. The potential functions are chosen to be smooth, resulting in bounded control inputs. Other constraints may also be imposed on the potential functions to satisfy various design criteria such as consensus, containment, and formation convergence. The effectiveness of the proposed control strategy is illustrated by simulation for examples of consensus and containment.
EXAMINATION OF AGILITY FACTORS OF JUNIOR FOOTBALL PLAYERS INBAČKA TOPOLA, SERBIA

The project was designed to collect data about junior football players using complex instrumental measurements. Agility is the ability to move easily and quickly; it infers rapid onset, sudden stops and changes in direction. The execution of these requires complex skill set. In modern football, this factor is considered the most important one in terms of efficiency. Several previous studies have, with no significant results, tried to find a link between individual skills and agility. In the present research we were looking for answers to what factors influence agility among junior football players. According to the of the movement-structure analysis of these tests, it is possible, that separately they do not cover the whole scale of movement patterns which could be present during a match. Because of this, we promoted two new variables: There are the "Agility without ball" and the "Agility with ball". This test of movement structure contains all the components which could be expected of the players during a match, such as changes of direction, dribbles, using the dominant and subdominant leg separately and optionally. In modern football, agility is an extremely complex skill, and the exact structure of its performance components is hard to define. The factors influencing players' agility should be emphasized and methodically developed in youth training in the light of future efficiency.
Intratracheal and oral administration of SM‐276001: A selective TLR7 agonist, leads to antitumor efficacy in primary and metastatic models of cancer

Topical TLR7 agonists such as imiquimod are highly effective for the treatment of dermatological malignancies; however, their efficacy in the treatment of nondermatological tumors has been less successful. We report that oral administration of the novel TLR7‐selective small molecule agonist; SM‐276001, leads to the induction of an inflammatory cytokine and chemokine milieu and to the activation of a diverse population of immune effector cells including T and B lymphocytes, NK and NKT cells. Oral administration of SM‐276001 leads to the induction of IFNα, TNFα and IL‐12p40 and a reduction in tumor burden in the Balb/c syngeneic Renca and CT26 models. Using the OV2944‐HM‐1 model of ovarian cancer which spontaneously metastasizes to the lungs following subcutaneous implantation, we evaluated the efficacy of intratracheal and oral administration of SM‐276001 in an adjuvant setting following surgical resection of the primary tumor. We show that both oral and intratracheal TLR7 therapy can reduce the frequency of pulmonary metastasis, and metastasis to the axillary lymph nodes. These results demonstrate that SM‐276001 is a potent selective TLR7 agonist that can induce antitumor immune responses when dosed either intratracheally or orally.
Content Analysis on Twitter Users Interaction within First 100 Days of Jakarta’s New Government by Using Text Mining

As one of the biggest democratic country in the world, Indonesia have very responsive society towards the various political move in either the central or local governments. In Indonesia, the first 100 days of new government era usually became a crucial timelines in which the society give their intents attention to government's performance. By the massive penetration of online social networking platform likes Twitter, the interaction between netizens and government figure official account will significantly increase. The povincial election for of Jakarta momentum was one of the most attractive political events in which Anies Baswedan and Sandiaga Uno were elected the lead of Jakarta government. The implication is the society would look intensively at their performance within their first 100 days. With the huge amount of Twitter users in Indonesia, Indonesian Twitter was very reactive towards any movement of Anies Sandi. Thus, this platform can be utilized to monitor the public opinion towards first 100 days of Anies Sandi government. In this study, we analyzed the content of conversations in interaction among the netizen and official Twitter Account of Anies Baswedan (@aniesbaswedan), Sandiaga Uno (@sandiuno) and the Government of Jakarta (@DKIJakarta). A set of text mining techniques was employed in this study.