Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of temperature on the changed slope of dissipation factor of oil paper insulation

In order to evaluate the effects of temperature on dielectric response, the frequency domain dielectric spectroscopy was transformed into temperature dielectric spectroscopy in this paper. Dealing with the data of the obtained temperature dielectric spectroscopy, and the changed slope of dissipation factor of the oil paper insulation samples was calculated at each temperature section. According to the obtained new feature parameter that the changed slope of dissipation factor, the influence of moisture content and aging time on the aging state of oil paper insulation system was analyzed. The experimental results showed that the changed slope of dissipation factor of moisture content and aging time samples increased continuously with the increase of temperature, and the effects of temperature on different moisture content and aging time samples were also reflected clearly by the changed slope of dissipation factor.
The Electoral Consequences of Issue Frames

What happens after issue frames shape public opinion? We offer an account of the downstream effects of issue frames on candidate choice. We then use three studies combining issue framing experiments with conjoint candidate choice experiments to directly assess these downstream effects. Despite an ideal setting for elite influence on public opinion, we find that frames ultimately have modest effects on how the public later evaluates politicians. Our theoretical framework highlights two sources of this disconnect. Frame-induced opinion change is only one component, often outweighed by other factors, in candidate choice, and the issues most amenable to framing are the least relevant for evaluating candidates. This introduces a new consideration into debates about the political consequences of issue frames. Even after they change the public’s policy opinions, issue frames may still have limited implications for other political outcomes.
The Female Sexual Function Index (FSFI): Translation, Validation, and Cross‐Cultural Adaptation of an Urdu Version “FSFI–U”

Abstract Introduction Female sexual dysfunction (FSD) is a common problem, and many self‐report questionnaires are available for its evaluation. Pakistani women with sexual problems feel shy to consult with their physician. A validated self‐report questionnaire, in the local language with modest expressions is required for these women. Aim The aim of this study was to translate, cross‐culturally adapt, and perform a psychometric validation of an Urdu translation of the Female Sexual Function Index (FSFI). Methods The FSFI was translated in Urdu, and its precision was ascertained through reverse translation. It was pretested on 22 bilingual women and refined again to reach at a reliable Urdu version of the questionnaire FSFI‐U. One hundred sixteen bilingual women, in a stable sexual relationship over the previous 6 months were finally asked to fill out the FSFI and FSFI‐U. Their sexual function was then clinically evaluated and responses were compared with the clinical assessment as well as with each other. Main Outcome Measures The responses were analyzed through descriptive statistics for reliability, face validity, agreement between the responses to the original English version and to the FSFI‐U, and also for test–retest consistency. The data were analyzed statistically using Cronbach's alpha analysis, Intraclass correlation coefficients, Pearson correlation, and Student's t‐test. Results FSFI was found to be easily understandable and capable of adequately evaluating and measuring various aspects of female sexual function. A high degree of internal consistency was demonstrated on Cronbach's alpha analysis. Cronbach's α coefficient for various domains was sufficiently high ranging from 0.84 to 0.97. The clinical assessment of the presence and severity of FSD also matched with the self‐report questionnaire. Similarly, various domains of FSFI had high degree of correlation in the Urdu version of FSFI (P < 0.001). Conclusion The Urdu translation version of FSFI is valid and reliable for use in the literate population of Pakistan. Rehman KU, Asif Mahmood M, Sheikh SS, Sultan T, Khan MA. The Female Sexual Function Index (FSFI): Translation, Validation, and Cross‐Cultural Adaptation of an Urdu Version “FSFI–U”. Sex Med 2015;3:244–250.
Selection of priority groups for obesity prevention: current approaches and development of an evidence‐informed framework

Resources for obesity prevention interventions are inevitably limited, necessitating the selection of priority groups to ensure effective and equitable use of funds. This paper aims to review published approaches to selection of priority groups (‘target populations’) for obesity prevention, and to present the development of a new systematic framework for organizing and assessing evidence for selecting priority groups. A review was conducted of the process and justification described for selecting priority groups in a sample of obesity prevention publications. Using the results of this review and adaptation of theory and frameworks in both the obesity prevention and health promotion priority‐setting literature, a framework was developed for assessment of potential priority groups for obesity prevention. The published literature lacks discussion of and explicit processes for selection of priority groups for obesity prevention intervention. The new framework describes specific types of evidence that should be considered in the assessment of a potential priority group for obesity prevention and has applications for funding and implementing community‐based or settings‐level obesity prevention interventions and research. Application of this framework has the potential to enhance the effective use of limited obesity prevention resources and to identify areas in need of additional research evidence.
Use of placental vascularization indices and uterine artery peak systolic velocity in early detection of pregnancies complicated by gestational diabetes, chronic or gestational hypertension, and preeclampsia at risk

Aim We aimed to investigate correlations between uterine artery peak systolic velocity (AUtPSV), and placental vascularization in groups of normal blood pressure (NBP) and hypertensive disorders of pregnancy (chronic hypertension (CHT), gestational hypertension (GHT) and preeclampsia (PE)) alone or in combination with gestational diabetes mellitus (GDM), and hypothesized that AUtPSV rises when GDM complicates pregnancy hypertension. Methods Placental 3-dimensional power Doppler indices, such as vascularization index (VI), flow index (FI), and vascularization-flow index (VFI), and uterine artery peak systolic velocity (AUtPSV) were measured in CHT (N = 43), CHT+GDM (N = 15), GHT (N = 57), GHT+GDM (N = 23) and PE (N = 17) pregnancies, and compared to NBP (N = 109). Correlations were analyzed between vascularization indices, AUtPSV, pregestational BMI and adverse pregnancy outcome rates. Results In our results VI was higher in CHT (P = 0.010), while FI was lower in CHT (P = 0.009), GHT and PE (P = 0.001) compared to NBP. In case of VFI, significant difference was found between CHT and GHT (P = 0.002), and NBP and PE (P = 0.001). FI was found prognostic for umbilical pH and neonatal birth weight. Pre-gestational BMI was significantly higher in GHT+GDM compared to GHT, and in CHT+GDM compared to the CHT group. As for AUtPSV, significant difference was found between NBP and CHT (P = 0.012), NBP and CHT+GDM (P = 0.045), NBP and GHT+GDM (P = 0.007), NBP and PE (P = 0.032), and GHT and GHT+GDM (P = 0.048) groups. Conclusion Our study revealed that vascularization indices and AUtPSV show significant differences due to gestational pathology, and can be useful in detection of pregnancies at risk.
A pilot study of therapeutic vaccination with envelope protein E1 in 35 patients with chronic hepatitis C

New treatments are needed for chronic hepatitis C patients in whom viral clearance cannot be achieved. Thirty‐five chronic hepatitis C patients (genotype 1) were randomized to receive 20 μg of recombinant HCV E1 (E1) (n = 26) or placebo (n = 9) intramuscularly at weeks 0, 4, 8, 12, and 24. Thirty‐four then received open‐label E1 vaccine at weeks 50, 53, 56, 59, 62, and 65. Twenty‐four patients (12 men, 12 women; mean age, 52 y; 18 interferon‐based treatment failures; mean baseline alanine aminotransferase [ALT] level, 118 IU/L) underwent a biopsy before and after 2 courses of E1, 17 months later. Liver histology was scored by 2 blinded pathologists according to the Ishak and Metavir systems. Postinjection reactions were similar to placebo (alum only). Nine of 24 patients (38%) had improvement of 2 points or more, 10 (41%) remained stable, and 5 (21%) showed worsening in total Ishak score. Nine patients (38%) improved both on Ishak and Metavir fibrosis scores. Plasma HCV‐RNA levels remained unchanged, whereas ALT levels showed a trend toward a decrease during treatment. All but 3 patients developed a significant de novo E1‐specific T‐cell response. The increase in anti‐E1 antibody levels correlated with the decrease in total Ishak score and with the relative decreases in both Ishak fibrosis score and ALT level (all P ≤ .01). In conclusion, E1 therapeutic vaccination is well tolerated and the observed effects warrant further study.
Hormone Ontogeny in the Ovine Fetus: XIX: The Effect of a Potent Luteinizing Hormone-Releasing Factor Agonist on Gonadotropin and Testosterone Release in the Fetus and Neonate'

ABSTRACT: To investigate further the role of the hypothalamic luteinizing hormone releasing factor (LRF) pulse generator and the pituitary LRF receptor in the regulation of gonadotropin secretion and gonadal steroidogenesis in the ovine (O) fetus and neonatal lamb, we measured the increment (the difference between the concentration of plasma LH at time 0 and peak LH) in oLH (AoLH) and oFSH (AoFSH) responses to a potent LRF agonist, D-Trp6Pro9NEt-LRF (LRF-A), after consecutive daily doses in 17 ovine fetuses (six females, 11 males) and in 15 neonatal lambs (six females, nine males). Seven of the lambs had been studied as fetuses. In addition, plasma concentrations of testosterone (T) and androstenedione (A4A) were measured in nine male fetuses. After a stimulatory response to the first dose of LRF-A, the mean AoLH and AoFSH responses in the 106- to 118-d gestation fetuses of both sexes were significantly suppressed by the fourth dose and in the neonatal lamb by the second dose. Suppression was sustained throughout the duration of LRF-A therapy which included the gestational interval when the fetal pituitary exhibits its greatest responsiveness to an acute dose of synthetic LRF. The duration of oLH and oFSH suppression after cessation of LRF-A therapy was studied by measuring the AoLH and AoFSH responses to LRF before and at intervals after LRF-A therapy. In the fetus, the AoLH and AoFSH responses remained significantly decreased 7-8 d after the agonist was discontinued. No statistical differences were detected in the AoLH and AoFSH responses to LRF in the neonatal lamb at least by the 4th d after discontinuation of LRF-A. Increasing the duration of LRF-A therapy did not prolong the length of recovery of LH and FSH responsiveness to LRF in either fetus or neonate. Mean fetal plasma T levels rose significantly in response to a single dose of LRF or LRFA. Peak T responses to single dose LRF or LRF-A were lower on d 2-4 and d 7 than on the 1st d of LRF-A
Distributed Computing As Business Model within Smart Grids

Some types of renewable energy resources like wind energy or solar cells are bonded to problems such as the energy providing pattern that does not fulfill the needs of the electric energy consumers. This situation leads the provider to the problem that an electric network always has to be balanced – the amount of provided energy must be the same as the consumed one. In a worst case scenario this leads to a situation where providing electric energy will not be service – instead it will be invoice able by the consumer. The energy consumption of modern computer systems is increased based on the higher performance available for consumers. This trend will increase based on the spread of personal computer systems to individuals. In context to the problem of controllable network load provider within a power grid, this development could be a chance: data centers are acting as cloud providers and even personal computers are capable to provide great amounts of processing power as well as network load capabilities. The major difference between these computers and other network load devices is the already existing infrastructure connectivity to control the behavior externally. This paper provides a concept of a business model and associated controlling software which presents an economic added-value to both electric power providers and consumers.
Pathophysiology of premature skin aging induced by ultraviolet light.

BACKGROUND Long-term exposure to ultraviolet irradiation from sunlight causes premature skin aging (photoaging), characterized in part by wrinkles, altered pigmentation, and loss of skin tone. Photoaged skin displays prominent alterations in the collagenous extracellular matrix of connective tissue. We investigated the role of matrix-degrading metalloproteinases, a family of proteolytic enzymes, as mediators of collagen damage in photoaging. METHODS We studied 59 whites (33 men and 26 women, ranging in age from 21 to 58 years) with light-to-moderate skin pigmentation, none of whom had current or prior skin disease. Only some of the participants were included in each of the studies. We irradiated their buttock skin with fluorescent ultraviolet lights under standard conditions and obtained skin samples from irradiated and nonirradiated areas by keratome or punch biopsy. In some studies, tretinoin and its vehicle were applied to skin under occlusion 48 hours before ultraviolet irradiation. The expression of matrix metalloproteinases was determined by in situ hybridization, immunohistology, and in situ zymography. Irradiation-induced degradation of skin collagen was measured by radioimmunoassay of soluble cross-linked telopeptides. The protein level of tissue inhibitor of matrix metalloproteinases type 1 was determined by Western blot analysis. RESULTS A single exposure to ultraviolet irradiation increased the expression of three matrix metalloproteinases -- collagenase, a 92-kd gelatinase, and stromelysin -- in skin connective tissue and outer skin layers, as compared with nonirradiated skin. The degradation of endogenous type I collagen fibrils was increased by 58 percent in irradiated skin, as compared with nonirradiated skin. Collagenase and gelatinase activity remained maximally elevated (4.4 and 2.3 times, respectively) for seven days with four exposures to ultraviolet irradiation, delivered at two-day intervals, as compared with base-line levels. Pretreatment of skin with tretinoin (all-trans-retinoic acid) inhibited the induction of matrix metalloproteinase proteins and activity (by 70 to 80 percent) in both connective tissue and outer layers of irradiated skin. Ultraviolet irradiation also induced tissue inhibitor of matrix metalloproteinases-1, which regulates the enzyme. Induction of the inhibitor was not affected by tretinoin. CONCLUSIONS Multiple exposures to ultraviolet irradiation lead to sustained elevations of matrix metalloproteinases that degrade skin collagen and may contribute to photoaging. Treatment with topical tretinoin inhibits irradiation-induced matrix metalloproteinases but not their endogenous inhibitor.
McWRI1, a transcription factor of the AP2/SHEN family, regulates the biosynthesis of the cuticular waxes on the apple fruit surface under low temperature

Cuticular waxes of plant and organ surfaces play an important role in protecting plants from biotic and abiotic stress and extending the freshness, storage time and shelf life in the post-harvest agricultural products. WRI1, a transcription factor of AP2/SHEN families, had been found to trigger the related genes taking part in the biosynthesis of seed oil in many plants. But whether WRI1 is involved in the biosynthesis of the cuticular waxes on the Malus fruits surface has been unclear. We investigated the changes of wax composition and structure, the related genes and WRI1 expression on Malus asiatica Nakai and sieversii fruits with the low temperature treatments, found that low temperature induced the up-regulated expression of McWRI1, which promoted gene expression of McKCS, McLACs and McWAX in very-long-chain fatty acid biosynthesis pathway, resulting in the accumulation of alkanes component and alteration of wax structure on the fruit surface. Corresponding results were verified in McWRI1 silenced by VIGS, and WRI1 silenced down-regulated the related genes on two kinds of fruits, it caused the diversity alteration in content of some alkanes, fatty acid and ester component in two kinds of fruits. We further conducted Y1H assay to find that McWRI1 transcription factor activated the promoter of McKCS, McLAC and McWAX to regulate their expression. These results demonstrated that McWRI1 is involved in regulating the genes related synthesis of very long chain fatty acid on surface of apple fruits in storage process, providing a highlight for improvement of the modified atmosphere storage of apple fruits.
Transcriptional Analysis of the Genetic Element pSSVx: Differential and Temporal Regulation of Gene Expression Reveals Correlation between Transcription and Replication

ABSTRACT pSSVx from Sulfolobus islandicus strain REY15/4 is a hybrid between a plasmid and a fusellovirus. A systematic study performed by a combination of Northern blot analysis, primer extension, and reverse transcriptase PCR revealed the presence of nine major transcripts whose expression was differentially and temporally regulated over the growth cycle of S. islandicus. The map positions of the RNAs as well as the clockwise and the anticlockwise directions of their transcription were determined. Some genes were clustered and appeared to be transcribed as polycistronic messengers, among which one long transcriptional unit comprised the genes for the plasmid copy number control protein ORF60 (CopG), ORF91, and the replication protein ORF892 (RepA). We propose that a termination readthrough mechanism might be responsible for the formation of more than one RNA species from a single 5′ end and therefore that the nine different RNAs corresponded to only seven different transcriptional starts. Three transcripts, ORF76 and two antisense RNAs, countertranscribed RNA1 (ctRNA1) and ctRNA2, were found to be specifically expressed during (and hence correlated to) the phase in which the pSSVx copy number is kept under stringent control, as they were completely switched off upon the onset of the induction of replication.
Highly secured cloud based personal health record model

Presently, cloud computing is widely used for storing, maintaining and sharing data. Sensitive files such as Personal Health Records are also outsourced to cloud and hence security is a major issue. Privacy and fine grained data access control are other risks in securing health records. User's valuable data should be secured so that they will entrust the Cloud Service Providers. Encryption is the most suitable option to protect sensitive records. In this paper Multi Authority and Key Policy Attribute Based Encryption techniques are used to encrypt health records after dividing these records to private and public domains. Further security is increased by providing session passwords to users and implementing session regeneration.
Evaluation of the Effect of Heating an Oil-Emulsion Pasteurella multocida Bacterin on Tissue Reaction and Immunity

SUMMARY. Killed vaccines in oil emulsions are critical components of breeder and layer vaccination programs. Current vaccination sites are limited, and each has inherent problems. Oil emulsion vaccines are associated with increased condemnations of spent fowl when vaccines are injected intramuscularly into the breast. In an attempt to reduce tissue reaction when injected into the breast muscle, a commercially available Pasteurella multocida bacterin was heated to 41 C (100 F) for 5 hr prior to administration. A second treatment group was injected with the same bacterin at room temperature, 25 C. The vaccine was injected into the breast muscle at 10 and 18 wk of age into white Leghorn hens. Seroconversion was evaluated using P. multocida enzyme-linked immunosorbent assay (ELISA) at 10, 18, and 24 wk. Treatment and control groups were euthanized and lesions scored at 24 wk of age. One replicate was challenged with type 1 P. multocida at 24 wk of age. Lesion scores for the heated vaccine group were significantly lower than the room temperature vaccine. ELISA titers were not significantly different at 24 wk between the two treatment group; however, a significant rise in antibody titer was observed at 18 wk in the group that was injected with the heated vaccine. Survivability to challenge was improved in birds injected with the heated vaccine. Results suggest that heating of a P. multocida bacterin reduces local tissue reaction without having a deleterious effect on immunity as measured by ELISA and challenge.
Structure of Apolipophorin-III in Discoidal Lipoproteins

The structure of apolipophorin III in the lipid-bound state and the extent of the conformational change that takes place when the five-helix bundle apolipoprotein binds to a lipoprotein lipid surface were investigated by fluorescence resonance energy transfer in discoidal lipoproteins. Four intramolecular interhelical distances between helix pairs 1–4, 2–4, 3–4, and 5–4 were estimated by fluorescence resonance energy transfer in both the lipid-free and the lipid-bound states. Depending on the helices pairs, the intramolecular interhelical distances increased between 15 and ≥ 20 Å upon binding of the apolipoprotein to lipid, demonstrating for the first time that binding to lipid is accompanied by a major change in interhelical distances. Using discoidal lipoproteins made with a combination of apolipophorin III molecules containing donor and acceptor groups and apolipophorin III molecules containing neither donor nor acceptor groups, it was possible to obtain information about intermolecular interhelical distances between the helix 4 of one apolipoprotein and the helices 1, 2, 3, and 5 of a second apolipoprotein residing in the same discoidal lipoprotein. Altogether, the estimated intermolecular and intramolecular interhelical distances suggest a model in which the apolipoprotein arranges in pairs of antiparallel and fully extended polypeptide chains surrounding the periphery of the bilayer disc.