Miracle-dz/UniFAR-FTUs huggingface dataset:
[EMDR and Cognitive-Behavioural Therapy in the treatment of Panic Disorder: a comparison].

AIM A comparison between two treatments used in the Panic Disorder: EMDR, an evidence-based method for PTSD, and Cognitive Behavioural Therapy (CBT), which is nowadays considered the most effective psychotherapeutic approach for this disorder. METHOD In order to evaluate any improvement obtained from the adopted treatment, a descriptive analysis through the use of the SPSS software has been carried out, on a sample of 20 subjects, divided in two groups (EMDR and CBT). RESULTS From the data obtained, a tendency to improve is already clear from the first evaluation (after 12 sessions), in all the proposed tests. The symptomatic progress turned out to be quite similar in the two compared groups. EMDR treatment however seems to have a faster progress in symptom reduction which is maintained over time, as evidenced at follow-up. CONCLUSION From the showed results, it is possible to confirm that both treatments are effective for the resolution of a Panic Disorder, even if some differences between the two therapies are clear, both from a symptomatic and a timing point of view. So, it is suggested to carry on the research in this area of interest.
Solidification of stainless steel slag by accelerated carbonation

Abstract On exposure to carbon dioxide (CO2) at a pressure of 3 bars, compacts formed from pressed ground slag, and 12.5 weight percent water, were found to react with approximately 18% of their own weight of CO2. The reaction product formed was calcium carbonate causing the slag to self‐cement. Unconfined compressive strengths of 9MPa were recorded in carbonated compacts whereas strengths of <1 MPa were recorded in non‐carbonated slag compacts. As molten stainless steel slag containing dicalcium silicate (C2S) cools it can undergo several phase transitions. The final transformation from the p‐polymorph to γ‐C2S is accompanied by a volume change that causes the slag to self‐pulverise or ‘dust’. As a consequence of this the fine grained portion of the slag contains more of this phase whilst the coarser particles of the slag contain more of the calcium magnesium silicates that contribute the bulk of the waste. The fine fraction (<125μm) of the slag when ground is found to react to the same extent as the ground bulk slag and produces compacts with equivalent strength. A coarser fraction (4–8mm) when ground to a similar grading does not react as extensively and produces a weaker product. Additions of ordinary Portland cement (OPC) at 5 and 10 percent by weight did not alter the degree of reaction during carbonation of the bulk slag or ground fine fraction, however the strength of the 4–8mm fraction was increased by this change.
Clinical impact of anti‐D in intravenous immunoglobulin

are required. Because anti-HPA-la was present at the time of the first RBC transfusion but thrombocytopenia did not develop for 7 days, it is not likely that the destruction of autologous platelets was due to simple adsorption of HPA-la from the transfusion. The simultaneous development of immunemediated hemolysis and thrombocytopenia may be more frequent than is suspected. It may be helpful to test for platelet antibodies when patients present with an RBC transfusion reaction associated with a simultaneous decrease in platelet count. Jane L. Swanson, MS Shelley Pulkrabek, BS Terry L. Scofield, BS David F. Stroncek, MD Nigel S. Key, MD, MRCP Department of Laboratory Medicine and Pathology University of Minnesota Hospital and Clinic Minneapolis, MN 55455
The resistance of varroa mites (Acari: Varroidae) to acaricides and the presence of esterase

Abstract Varroa mites (Varroa destructor Anderson and Trueman, 2000) are becoming resistant to acaricide treatments via metabolic and/or target site desensitivity. Results of a survey of mites from the Carl Hayden AZ lab and from cooperators in five locations (Arizona, California, Florida, Maine, North Dakota) showed that some mites were susceptible to all three acaricides (Amitraz, Coumaphos, Fluvalinate) in the spring of 2003, but by fall most mites were resistant. Mites were resistant to all chemicals, even from beekeepers that do not treat colonies with acaricides. We used esterase native activity gels to test for the presence of specific esterases which might be involved in pesticide resistance in varroa. All mites tested had positive bands for esterase, even those exhibiting susceptibility to some acaricides. Based on the differences between the esterase activity gel profile of the susceptible and cross-resistant V. destructor, it is possible that an esterase-mediated resistance mechanism is operative in the population of the mites we analyzed. However, a combination of other resistance mechanisms may be present which make the esterase activity gel method unreliable for use in identifying varroa mites with multiple resistance.
Coherent phonon dynamics in single-layer and multilayer graphene

Coherent phonon dynamics of single-layer graphene (SLG) and multi-layer graphene (MLG) on sapphire substrate were investigated using femtosecond pump-probe techniques. The center peak of G-mode phonon redshift with the number of graphene layer and the temperature increases in the temperature range between 300 K and 900 K. Also, the dephasing time upshift from 0.82 ps to 1.14 ps as the number of graphene layer increases. This results reflect thermal expansion and damping constant of SLG and MLG.
Suicide Ideation Among College Students Evidencing Subclinical Depression

Abstract Identifying elevated suicide ideation in college students is a critical step in preventing suicide attempts and deaths by suicide on college campuses. Although suicide ideation may be most prominent in students with severe depression, this should not suggest that only students with severe depression experience significant risk factors for suicide. Objective: The purpose of these 3 studies was to explore the relation between suicide ideation and severity of depressive symptoms in college students. Participants: In each study a sample of college students were recruited for participation. Methods: Participants completed self-report assessments of depressive symptoms and suicide ideation. Results: The results of these studies suggest that although the greatest elevation in suicide ideation occurs at the highest depressive symptoms, significant suicide ideation is also experienced by college students with mild and moderate depressive symptoms. Conclusions: The implications of these findings for the assessment of suicide ideation are discussed.
A Role for Tumor Necrosis Factor Receptor-2 and Receptor-interacting Protein in Programmed Necrosis and Antiviral Responses*

Members of the tumor necrosis factor (TNF) receptor (TNFR) superfamily are potent regulators of apoptosis, a process that is important for the maintenance of immune homeostasis. Recent evidence suggests that TNFR-1 and Fas and TRAIL receptors can also trigger an alternative form of cell death that is morphologically distinct from apoptosis. Because distinct molecular components including the serine/threonine protein kinase receptor-interacting protein (RIP) are required, we have referred to this alternative form of cell death as “programmed necrosis. ” We show that TNFR-2 signaling can potentiate programmed necrosis via TNFR-1. When cells were pre-stimulated through TNFR-2 prior to subsequent activation of TNFR-1, enhanced cell death and recruitment of RIP to the TNFR-1 complex were observed. However, TNF-induced programmed necrosis was normally inhibited by caspase-8 cleavage of RIP. To ascertain the physiological significance of RIP and programmed necrosis, we infected Jurkat cells with vaccinia virus (VV) and found that VV-infected cells underwent programmed necrosis in response to TNF, but deficiency of RIP rescued the infected cells from TNF-induced cytotoxicity. Moreover, TNFR-2–/– mice exhibited reduced inflammation in the liver and defective viral clearance during VV infection. Interestingly, death effector domain-containing proteins such as MC159, E8, K13, and cellular FLIP, but not the apoptosis inhibitors Bcl-xL, p35, and XIAP, potently suppressed programmed necrosis. Thus, TNF-induced programmed necrosis is facilitated by TNFR-2 signaling and caspase inhibition and may play a role in controlling viral infection.
Users' Perceptions Using Low-End and High-End Mobile-Rendered HMDs: A Comparative Study

Currently, it is possible to combine Mobile-Rendered Head-Mounted Displays (MR HMDs) with smartphones to have Augmented Reality platforms. The differences between these types of platforms can affect the user’s experiences and satisfaction. This paper presents a study that analyses the user’s perception when using the same Augmented Reality app with two MR HMD (low-end and high-end). Our study evaluates the user’s experience taking into account several factors (control, sensory, distraction, ergonomics and realism). An Augmalpha-lowerented Reality app was developed to carry out the comparison for two MR HMDs. The application had exactly the same visual appearance and functionality for both devices. Forty adults participated in our study. From the results, there were no statistically significant differences for the users’ experience for the different factors when using the two MR HMDs, except for the ergonomic factors in favour of the high-end MR HMD. Even though the scores for the high-end MR HMD were higher in nearly all of the questions, both MR HMDs provided a very satisfying viewing experience with very high scores. The results were independent of gender and age. The participants rated the high-end MR HMD as the best one. Nevertheless, when they were asked which MR HMD they would buy, the participants chose the low-end MR HMD taking into account its price.
Characteristics of depressive symptoms in elderly urban and rural African Americans.

BACKGROUND Despite considerable progress in the epidemiology of late life depression, little data have been documented in the scientific literature on depressive symptoms among elderly African Americans. The present investigation identifies characteristic symptoms of depression in African American community-resident elders. METHOD Ninety-six African American men and women aged 60 years and older, with equal representation from urban and rural counties in west Tennessee, composed the sample. The sample was stratified in each of the two counties into three age categories; 60-69, 70-79, and 80 and older. Data from the Center for Epidemiological Studies-Depression scale were compared with the association of medical illness, medication use, social network, level of physical function in activities of daily living, and demographic characteristics. RESULTS Residents screening positive for the presence of depressive symptoms showed an increased report of hypertension (p < .036), arteriosclerosis (p < .035), and circulatory problems (p < .008). There was an increased report of symptoms of depression among those who had six or more different chronic illnesses (p < .001) and among those who reported using four or more different prescription medications in the past month for chronic illnesses (p < .015). Regression analyses of data indicated that medical illness (p < .001) and social network (p < .041) were the most important predictors of depressive symptoms among residents. CONCLUSIONS Considering the projected increase of African Americans reaching age 60, and because depressive illness is an important public heath concern, early identification of salient risk factors for depression is critical in instituting early intervention programs for the ethnic minority elderly population.
A CFAR algorithm for layover and shadow detection in InSAR images based on kernel density estimation

In this paper, a novel CFAR algorithm for detecting layover and shadow areas in Interferometric synthetic aperture radar (InSAR) images is proposed. Firstly, the probability density function (PDF) of the square root amplitude of InSAR image is estimated by the kernel density estimation. Then, a CFAR algorithm combining with the morphological method for detecting both layover and shadow is presented. Finally, the proposed algorithm is evaluated on a real InSAR image obtained by TerraSAR-X system. The experimental results have validated the effectiveness of the proposed method.
Mutagenically Separated PCR Assay for Rapid Detection of M41L and K70R Zidovudine Resistance Mutations in CRF01_AE (Subtype E) Human Immunodeficiency Virus Type 1

ABSTRACT A rapid zidovudine (ZDV) resistance genotypic assay was developed based on the mutagenically separated PCR (MS-PCR) technique to detect two ZDV-resistant mutations, M41L and K70R in CRF01_AE (subtype E). Endpoint dilution analysis revealed that the newly constructed MS-PCR assay could successfully detect three to nine copies of human immunodeficiency virus type 1 template RNA. The test against wild-type and mutant template mixtures in different ratios demonstrated that the assay could detect 10% minor population, at least. Fifty-one subtype E clinical samples were analyzed by the newly constructed MS-PCR assay and direct nucleotide sequencing. The concordance of the two assays was 92 and 100% in codons 41 and 70, respectively. The MS-PCR assay is a rapid, simple, and inexpensive assay that is highly sensitive in detecting mutant targets, including minor populations. Thus, it could be used as a powerful tool for epidemiological surveillance of drug-resistant mutations in developing countries.
Interpretation of repeated tuberculin tests. Boosting, conversion, and reversion.

The tuberculin skin test is one of the few tests developed in the 19th century that is still in present use in clinical medicine. The first tuberculin test material was prepared by Robert Koch (1); its use for detection of tuberculosis (TB) infection was first described in 1907 by von Pirquet (2). Given such a long history of use, it may seem surprising that aspects of interpretation of this test remain controversial. However, this reflects changes in the populations affected with tuberculosis and their relative frequency of true positive tests from TB infection, and false-positive tests associated with bacillus Calmette-Guerin (BCG) vaccination, or nontuberculous mycobacteria, as well as the recent human immunodeficiency virus (HIV) epidemic. Particular problems have arisen with use of repeated tuberculin tests to detect new infection in high-risk populations such as initially tuberculin-negative contacts of active cases, and workers with occupational exposure. This has revealed that tuberculin reactions may decrease in size (reversion) or increase in size because of: ( 1 ) random variability from differences in administration, reading, or biologic response; ( 2 ) immunologic recall of preexisting delayed type hypersensitivity to mycobacterial antigens (boosting); or ( 3 ) new infection (conversion). This review has been undertaken to provide information regarding factors causing changes in the size of repeated tuberculin reactions.
The new DSM-5 diagnosis of mild neurocognitive disorder and its relation to research in mild cognitive impairment

The Diagnostic Statistical Manual-5 (DSM-5) has included a category named the neurocognitive disorder which was formally known in DSM-IV as ‘dementia, delirium, amnestic, and other cognitive disorders’. The DSM-5 distinguishes between ‘mild’ and ‘major’ neurocognitive disorders. Major neurocognitive disorder replaces the DSM-IV's term ‘dementia or other debilitating conditions’. A pivotal addition is ‘mild neurocognitive disorder (mNCD)’ defined by a noticeable decrement in cognitive functioning that goes beyond normal changes seen in aging. It is a disorder that may progress to dementia – importantly, it may not. Presently, our understanding of mNCD is derived from research on mild cognitive impairment (MCI). Whereas there is currently no clear treatment for mNCD, many experimental therapies now and into the future will focus upon secondary prevention, namely decreasing the risk of progression to major NCD. In this article, we will focus on mNCD by reviewing the relevant literature on MCI. We will review the research on the incidence and prevalence of MCI, conversion rates from MCI to dementia, risk factors for conversion of MCI to dementia, comorbidity of MCI with other neuropsychiatric disorders (NPS), and the development of treatment strategies for neuropsychiatric disorders in MCI. The presence of NPS is common among individuals with MCI and is an important risk for progression to dementia. However, there has been little research on effective treatments for NPS in MCI. Clinicians and investigators must determine if the treatment of the NPS in mNCD will improve quality of life and help reduce the progression of the cognitive impairment.
New Potent Bisubstrate Inhibitors of Histone Acetyltransferase p300: Design, Synthesis and Biological Evaluation

Bisubstrate‐type compound Lys‐CoA has been shown to inhibit the p300 histone acetyl transferase activity efficiently and may constitute a lead compound for a novel class of anticancer therapeutics. Based on this strategy, we synthesized a series of CoA derivatives and evaluated these molecules for their activity as p300 histone acetyltransferases inhibitor. The best activity was obtained with compound 3 bearing a C‐5 spacing linker that connects the CoA moiety to a tert‐butyloxycarbonyl (Boc) group. Based on docking simulations, this inhibitor exhibits favorable interactions with two binding areas, namely pockets P1 and P2, within the active site.
2D Imaging Algorithm for the Evaluation of UWB B-Scans

This paper proposes an ultra-wideband imaging radar system using B-scans for the target identification. The two dimensional inverse boundary scattering transform was successfully applied for through-wall imaging applications. Using this algorithm it is not only possible to detect the target but also to reconstruct the surface curvature of a cylinder behind a wall. Moreover, it is shown that only 24 different positions of the antennas are sufficient to estimate the target shape which results in a low computation time
127.5 kbps Transmission using OLED with 7 kHz 3dB modulation bandwidth in visible light communication system

In this paper, a visible light communications (VLC) system prototype using OLED was realized and tested. Using simple DPPM technique and comparator, our prototype was able to transmit up to 127.5 kbps data rate using an OLED with only 7 kHz 3 dB modulation bandwidth. Exploiting the frequency response of OLED, we were able to achieve a better data rate to modulation bandwidth ratio than other recent reports using OLED for VLC.
Energy transfer via linear doubly-fed motor in different operating modes

The potential to transfer energy from the primary to the secondary of an asynchronous linear doubly-fed motor is investigated for different operating modes taking care of detailed losses modeling in both primary and secondary parts of the motor. The degrees of freedom for the operating point assignment and the energy transfer are discussed and a multiobjective optimization process is described and utilized to achieve an efficient energy transfer. For investigation of particular questions of thrust generation and energy transfer, a test bed of 8 m length is utilized for validation.
Endocrine and metabolic changes during altered growth rates in beef cattle.

Eight steers from a group of 14 were fed ad libitum from 240 to 510 kg live weight, gaining at 1.4 +/- . 2 kg/d. The six other steers were diet-restricted and grew at . 37 +/- . 09 kg/d from 240 to 307 kg, prior to ad libitum realimentation on the same diet to a final weight of 510 kg. Blood samples taken during the growth phases from both treatments were analyzed for insulin-like growth factor-I (IGF-I), triiodothyronine (T3), thyroxine (T4), glucose (GLU), nonesterified fatty acids (NEFA), and blood urea nitrogen (BUN) and (or) growth hormone (GH). During restricted growth, mean serum concentrations of GH were elevated (45.6 vs 23.4 ng/ml; P less than .05), serum concentrations of IGF-I decreased (108 vs 167 ng/ml; P less than .05) compared with control steers with ad libitum access to feed. Levels of T4 and GLU also were lower (P less than .05) during restricted than during normal growth. During early realimentation, levels of GLU (P less than .05), IGF-I (P less than .01), T4 and BUN (P less than .01) increased. Levels of T3 remained unchanged, whereas concentration of NEFA declined (P less than .001). Blood urea nitrogen decreased during early realimentation despite a large increase in diet protein intake and in protein storage, suggesting an increased efficiency of nitrogen use for protein synthesis. During realimentation, IGF-I levels rose above those of control steers and remained higher at the final weight of 510 kg (P less than .05). (ABSTRACT TRUNCATED AT 250 WORDS)
Deriving Generic Statements using Corpus Acquired Knowledge and WordNet

Existing work in the extraction of commonsense knowledge from text has been restricted to factoids that serve as statements about what may possibly obtain in the world. We present an approach to deriving stronger general claims from large sets of factoids. The idea is to coalesce the observed nominals for a given predicate argument into a few predominant types, obtained as WordNet synsets. The results can be construed as generically quantified sentences restricting the semantic type of an argument position of a predicate. This work was funded by NSF grants IIS-0328849 and IIS-0535105.
In Vivo Helper Functions of Alloreactive Memory CD4+ T Cells Remain Intact Despite Donor-Specific Transfusion and Anti-CD40 Ligand Therapy1

Memory T cells have specific properties that are beneficial for rapid and efficient protection from pathogens previously encountered by a host. These same features of memory T cells may be deleterious in the context of a transplanted organ. Consistent with this contention is the accumulating evidence in experimental transplantation that previously sensitized animals are resistant to the effects of costimulatory blockade. Using a model of murine cardiac transplantation, we now demonstrate that alloreactive memory CD4+ T cells prevent long-term allograft survival induced through donor-specific cell transfusion in combination with anti-CD40 ligand Ab (DST/anti-CD40L). We show that memory donor-reactive CD4+ T cells responding through the direct or indirect pathways of allorecognition provide help for the induction of antidonor CD8+ T effector cells and for Ab isotype switching, despite DST/anti-CD40L. The induced pathogenic antidonor immunity functions in multiple ways to subsequently mediate graft destruction. Our findings show that the varied functions of alloreactive memory CD4+ T cells remain intact despite DST/anti-CD40L-based costimulatory blockade, a finding that will likely have important implications for designing approaches to induce tolerance in human transplant recipients.