Miracle-dz/UniFAR-FTUs huggingface dataset:
Determinationof SeleniumConcentrationand GlutathionePeroxidase Activityin Plasmaand Erythrocytes

We determined selenium concentrations and activities of the selenoenzyme, glutathione peroxidase (EC 1.11.1.9), in the plasma and erythrocytes of 38 apparently healthy women. We determined selenium concentrations directly by polarized Zeeman-effect flameless atomic absorption spectroscopy. Within-run precision studies for the assays gave CVs of 5.6% for a mean erythrocyte selenium concentration of 149.9 (SD 8.3) rg/L (n = 10) and 6.4% for a mean plasma selenium concentration of 97.3 (SD 6.2) /1g/L (n = 12). For the women, mean selenium concentrations were 141.4 (SD 14.3) . tg/L of erythrocytes [0.49 (SD 0.07) ,rg/g of hemoglobin] and 96.3 (SD 14.2) j.gIL of plasma. Glutathione peroxidase activities were measured by a modification of the method of Paglia and Valentine (J. Lab. Gun. Med. 70: 158-169, 1967). Within-run precision studies for the glutathione peroxidase assays gave CVs of 12.8% for mean erythrocyte glutathione peroxidase activity of 77.2 (SD 9.9) U/g of hemoglobin (n = 13), and 8.1% for mean plasma activity of 312.5 (SD 25.2) U/L (n = 11). Mean enzyme activity was 78.7 (SD 12.9) U/g of hemoglobin for erythrocytes and 424 (SD 40) U/L for plasma. Erythrocyte selenium concentrations and glutathione peroxidase activities were positively, but poorly, correlated (r = 0.41, p <0.01).
The Penn State Worry Questionnaire: Comparative Model Fit and Invariance across Gender

This article identified a priori models of the Penn State Worry Questionnaire (PSWQ) identified in the extant literature and utilized bootstrapped confirmatory factor analysis (CFA) to investigate the comparative fit of the models in a nonclinical sample of college students (N = 502). Results indicated that CFA models with method effects provided relatively better fit in comparison to the original one-factor model proposed by Meyer et al. (1990). An abbreviated, 8item model provided a significant improvement in fit compared to 16-item models, and the present study extended assessed measurement invariance across gender for the abbreviated model. Results indicated that the abbreviated model displayed configural and factor loading invariance across gender but did not maintain scalar equivalence across gender. Results also indicated significant differences in terms of latent mean structure, with women displaying significantly higher levels of latent worry than men. Implications of scalar invariance are discussed.
Adaptive minimum BER reduced-rank interference suppression for very large multiuser MIMO systems

In this paper, we propose a novel adaptive reducedrank strategy for very large multiuser multi-input multi-output (MIMO) systems. The proposed reduced-rank scheme is based on the concept of joint iterative optimization (JIO) of filters according to the minimization of the bit error rate (BER) cost function. The proposed optimization technique adjusts the weights of a projection matrix and a reduced-rank filter jointly. We develop stochastic gradient (SG) algorithms for their adaptive implementation and introduce a novel automatic rank selection method based on the BER criterion. Simulation results for multiuser MIMO systems show that the proposed adaptive algorithms significantly outperform existing schemes. (5 pages)
Optimizing Recurrent Pulsing Attacks using Application-Layer Amplification of Open DNS Resolvers

Shrew attacks or pulsing attacks are low-bandwidth network-level/layer-3 denial-of-service attacks. They target TCP connections by selectively inducing packet loss to affect latency and throughput. We combine the recently presented DNS CNAME-chaining attack with temporal lensing, a variant of pulsing attacks, to create a new, harder to block attack. For an attack, thousands of DNS resolvers have to be coordinated. We devise an optimization problem to find the perfect attack and solve it by using a genetic algorithm. The results show pulses created with our attack are 14 times higher than the attacker’s average bandwidth. Finally, we present countermeasures applicable to pulsing and CNAME-chaining, which also apply to this attack.
ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication

Materials and methods: Th is is a prospective, open-label, single-centre study. Th e study involved 86 consecutive patients with nonulcer dyspepsia. All patients were randomly assigned into 2 study groups at a 2:1 ratio using random sampling numbers. Th e fi rst group of patients were administered a sequential treatment: pantoprazole 2 × 40 mg and amoxicillin 2 × 1000 mg for the fi rst 7 days and pantoprazole 2 × 40 mg, metronidazole 2 × 500 mg, and tetracycline 4 × 500 mg for the remaining 7 days. Th e second group of patients were administered pantoprazole 2 × 40 mg, amoxicillin 2 × 1000 mg, and clarithromycin 2 × 500 mg (PAC) for 14 days. Eradication was defi ned as the absence HP as assessed with the (14-C) urea breath test 4 weeks aft er the end of the antimicrobial therapy.
Abstract word count: 248words Airflow limitation and airway dimensions assessed per bronchial generation in older asthmatics (94/100words)

word count: 248words Airflow limitation and airway dimensions assessed per bronchial generation in older asthmatics (94/100words) Kaoruko Shimizu MD, Masaru Hasegawa MD, Hironi Makita MD, Yasuyuki Nasuhara MD, Satoshi Konno MD, and Masaharu Nishimura MD* First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan *Correspondence to: Masaharu Nishimura, M.D. First Department of Medicine, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, Sapporo 060-8638, Japan Tel: +81-11-706-5911; Fax: +81-11-706-7899 E-mail: ma-nishi@med.hokudai. ac.jp Running title (50/50letters): Airflow limitation and airway dimensions in asthma
Ocean acidification rapidly reduces dinitrogen fixation associated with the hermatypic coral Seriatopora hystrix

Since productivity and growth of coral-associated dinoflagellate algae is nitrogen (N)-limited, dinitrogen (N2) fixation by coral-associated microbes is likely crucial for maintaining the coraldinoflagellate symbiosis. It is thus essential to understand the effects future climate change will have on N2 fixation by the coral holobiont. This laboratory study is the first to investi- gate short-term effects of ocean acidification on N2 fixation activity associated with the tropical, hermatypic coral Seriatopora hystrix using the acetylene reduction assay in combination with cal- cification measurements. Findings reveal that simulated ocean acidification (p CO2 1080 µatm) caused a rapid and significant decrease (53%) in N2 fixation rates associated with S. hystrix com- pared to the present day scenario (p CO2 486 µatm). In addition, N2 fixation associated with the coral holobiont showed a positive exponential relationship with its calcification rates. This sug- gests that even small declines in calcification rates of hermatypic corals under high CO2 conditions may result in decreased N2 fixation activity, since these 2 processes may compete for energy in the coral holobiont. Ultimately, an intensified N limitation in combination with a decline in skeletal growth may trigger a negative feedback loop on coral productivity exacerbating the negative long-term effects of ocean acidification.
Olivine‐spinel transitions: Experimental and thermodynamic constraints and implications for the nature of the 400‐km seismic discontinuity

The sequence of high-pressure phase transitions α→β→γ in olivine is traditionally used as a model for seismic velocity variations in the 200- to 650-km-depth interval in a mantle of peridotitic bulk composition. It has been proposed that the observed seismic velocity increase at 400-km depth is too sharp and of too small a magnitude to be attributable to the α→β phase change and that the upper mantle must thus be chemically stratified, with the 400-km discontinuity being due either to a combination of phase changes in a layer of pyroxene/garnet-rich “piclogite” composition or to a chemical boundary between such a piclogite layer and an overlying peridotitic layer. Using available calorimetric, thermoelastic, and synthesis data (and their associated experimental uncertainties), we have derived internally consistent high-pressure phase relations for the Mg2SiO4-Fe2SiO4 join. We find that the divariant transition α→α+β→β, which is generally regarded as occurring over a broad depth interval for mantle olivine compositions, is, in fact, extremely sharp. The seismic discontinuity corresponding to the α→α+β→β transition in (Mg0.9Fe0.1)2SiO4 should occur over a depth interval (isothermal) of about 6 km at a depth of approximately 400 km; the sharpness of this transition is quite insensitive to uncertainties in the constraining calorimetric, thermoelastic, and synthesis data. In addition, we have computed seismic velocity profiles for a model mantle consisting of pure olivine of (Mg0.9Fe0.1)2SiO4 composition. Comparison of these computed profiles to those derived from recent seismic studies indicates that the magnitude of the observed velocity increase at 400-km depth is consistent with a mantle transition zone composed of about 60–70% olivine. We conclude that there is no need to infer the existence of pyroxene/garnet-rich compositions, such as eclogite or “piclogite,” in the transition zone, since an upper mantle of homogeneous olivine-rich peridotitic composition is consistent with the available seismic velocity data.
Modeling and Control of Livestock Ventilation Systems and Indoor Environments

The hybrid ventilation systems have been widely used for livestock barns to provide optimum indoor climate by controlling the ventilation rate and air flow distribution within the ventilated building structure. The purpose of this paper is to develop models for livestock ventilation systems and indoor environments with a major emphasis on the prediction of indoor horizontal variation of temperature and concentration adapted to the design of appropriate controlling strategy and control systems. The Linear Quadratic (LQ) optimal control method taking into account of the effect of necessary constraints and random disturbances is designed through system linearization. The well designed control systems are able to determine the demand ventilation rate and airflow pattern, improve and optimize the indoor Thermal Comfort (TC), Indoor Air Quality (IAQ) and energy use.
Photoinduced Hund excitons in the breakdown of a two-orbital Mott insulator

We study the photoinduced breakdown of a two-orbital Mott insulator and resulting metallic state. Using time-dependent density matrix renormalization group, we scrutinize the real-time dynamics of the half-filled two-orbital Hubbard model interacting with a resonant radiation field pulse. The breakdown, caused by production of doublon-holon pairs, is enhanced by Hund's exchange, which dynamically activates large orbital fluctuations. The melting of the Mott insulator is accompanied by a high- to low-spin transition with a concomitant reduction of antiferromagnetic spin fluctuations. Most notably, the overall time response is driven by the photogeneration of excitons with orbital character that are stabilized by Hund's coupling. Such Hund excitons, which can form a condensate, correspond to bound doublon-holon pairs with spin-singlet and orbital-triplet quantum numbers. Hund excitons are not directly bound by Coulomb or Hubbard-$V$ interactions, as other excitons, but due to Hund's exchange. We study exciton properties such as bandwidth, binding potential, and size within a semiclassical approach. The photometallic state, which results from a coexistence of Hund excitons and doublon-holon plasma, differs with the equilibrium concept of Hund's metal used in multiorbital physics.
Running head: Plant Mitochondrial Presequences Author for correspondence responsible for distribution of materials integral to the findings

Mitochondrial protein import is a complex multi-step process from synthesis of proteins in the cytosol, recognition by receptors on the organelle surface, to translocation across one or both mitochondrial membranes and assembly after removal of the targeting signal, referred to as a presequence. In plants, import has to further discriminate between mitochondria and chloroplasts. In this study, we determined the precise cleavage sites in the presequences for Arabidopsis and rice mitochondrial proteins using mass spectrometry by comparing the precursor sequences with experimental evidence of the Nterminal peptide from mature proteins. We validated this method by assessments of false-positive rates and comparisons with previous available data using Edman degradation. In total, the cleavable presequences of 62 proteins from Arabidopsis and 52 proteins from rice mitochondria were determined. None of these proteins contained Nterminal acetylation, in contrast to recent findings for chloroplast stromal proteins. Furthermore the classical matrix glutamate dehydrogenase was detected with intact and N-terminal acetylated sequence indicating that it is imported into mitochondria without a cleavable targeting signal. Arabidopsis and rice mitochondrial presequences had similar pI, hydrophobicity and the predicted ability to form an amphiphilic α-helix at the N-terminal region of the presequence, but variations in length, amino acid composition, and cleavage motifs for mitochondrial processing peptidase (MPP) were observed. A combination of lower hydrophobicity and start point of the N-terminal α-helix in mitochondrial presequences in both Arabidopsis and rice distinguished them (98%) from Arabidopsis chloroplast stroma transit peptides. Both Arabidopsis and rice mitochondrial cleavage sites could be grouped into three classes, with conserved -3R (Class II) and -2R (Class I) or without any conserved arginines (Class III). Class II were dominant in both Arabidopsis and rice (55-58%), but in rice sequences there was much less frequently a phenylalanine (F) in the -1 position of cleavage site than in Arabidopsis sequences. Our data also suggest a novel cleavage motif of (F/Y)↓(S/A) in plant Class III sequences. www.plantphysiol. org on October 31, 2017 Published by Downloaded from Copyright © 2009 American Society of Plant Biologists. All rights reserved.
Degradation of Fumigant Pesticides: 1,3-Dichloropropene, Methyl Isothiocyanate, Chloropicrin, and Methyl Bromide

Fumigant pesticides are frequently used in intensive agriculture to control nematodes, fungi, and weeds. Currently, four registered fumigants are available: 1,3-dichloropropene (1,3-D), methyl isothiocyanate (MITC), chloropicrin (CP), and methyl bromide (MeBr). The use of 1,3-D, MITC, and CP can be expected to increase after MeBr is completely phased out of production in the USA in 2005. In soil, the degradation of 1,3-D, MITC, CP, and MeBr occurs through both chemical and biological mechanisms. Repeated applications of the fumigants MITC and 1,3-D are known to enhance their biodegradation as a result of adapted microorganisms. Preliminary evidence suggests that the microorganisms responsible for enhanced degradation of MITC specifically target the isothiocyanate functional group. In the case of 1,3-D, a number of bacteria have been isolated that are capable of degrading 1,3-D and also using it as a sole C and energy source. Of the two isomers of 1,3-D, degradation of trans -1,3-D was found to be greater than that of cis -1,3-D in enhanced soil. Methyl bromide is mainly degraded chemically in soil by hydrolysis and methylation of nucleophilic sites on soil organic matter. Both degradation reactions occur via S 2 N nucleophilic substitution. Methanotrophic and ammonia-oxidizing bacteria can co-oxidize MeBr during the oxidation of methane and ammonia, respectively. The microbiological degradation of MeBr is apparently catalyzed by methane and ammonia monooxygenase. Chloropicrin can be dehalogenated by Pseudomonas spp. , with the major metabolic pathway occurring through three successive reductive dehalogenations to nitromethane.
Similarities Between the Binding Sites of Monoamine Oxidase (MAO) from Different Species — Is Zebrafish a Useful Model for the Discovery of Novel MAO Inhibitors?

Zebrafish (Danio rerio) is an animal model that is attracting increasing interest in pharmacol‐ ogy and toxicology. The relatively ease with which large numbers of individuals can be ob‐ tained and their inexpensive maintenance makes zebrafish a particularly suitable tool for drug discovery. Thus, in recent years diverse compounds have been assayed both in larval and adult specimens and changes of behavioral patterns, for instance, have been related to anxiolytic, addictive or cognitive effects. In this context, the molecular characterization of drug targets in zebrafish, comparing them to their mammalian counterparts, arises as a sub‐ ject of paramount importance.
Etravirine Induced Severe Hypersensitivity Reaction and Fulminant Hepatitis: A Case Report and Review of the Literature

We report the first published case of etravirine induced hypersensitivity reaction leading to fulminant hepatic failure in a 49-year-old female patient with Human Immunodefi ciency Virus. She presented with a life threatening rash and end stage organ damage requiring intensive care unit supportive care. Liver biopsy supported the diagnosis of drug-induced hypersensitivity. The patient recovered after withdrawal of etravirine and the use of systemic corticosteroids. The authors describe etravirine drug hypersensitivity as a clinically important reaction and that early recognition can improve survival.
Dephasing of a particle in a dissipative environment

The motion of a particle in a ring of length L is influenced by a dirty metal environment whose fluctuations are characterized by a short correlation distance ℓ ≪ L. We analyze the induced decoherence process, and compare the results with those obtained in the opposing Caldeira–Leggett limit (ℓ ≫ L). A proper definition of the dephasing factor that does not depend on a vague semiclassical picture is employed. Some recent Monte Carlo results about the effect of finite temperatures on ‘mass renormalization’ in this system are illuminated.
Liquid li structure and dynamics: A comparison between OFDFT and second nearest‐neighbor embedded‐atom method

The structure and dynamics of liquid lithium are studied using two simulation methods: orbital-free (OF) first-principles molecular dynamics (MD), which employs OF density functional theory (DFT), and classical MD utilizing a second nearest-neighbor embedded-atom method potential. The properties studied include the dynamic structure factor, the self-diffusion coefficient, the dispersion relation, the viscosity, and the bond angle distribution function. Simulation results were compared to available experimental data when possible. Each method has distinct advantages and disadvantages. For example, OFDFT gives better agreement with experimental dynamic structure factors, yet is more computationally demanding than classical simulations. Classical simulations can access a broader temperature range and longer time scales. The combination of first-principles and classical simulations is a powerful tool for studying properties of liquid lithium. © 2015 American Institute of Chemical Engineers AIChE J, 61: 2841–2853, 2015
Effects of In-utero Exposure to Maternal Fasting during Ramadan on Subjective Well-being and Health in Old Age

We use a new, high-frequency panel survey of elderly Singaporeans to study the effect of in-utero exposure to mild nutritional shocks on an individual’s later-life outcomes more comprehensively. The causal impact of such shocks is identified by exploiting the plausible randomness of the timing of pregnancies with respect to Ramadan. We find that in-utero exposure to Ramadan leads to poorer evaluative subjective well-being across a broad range of domains, as well as poorer mental well-being. Consistent with these subjective measures and predictions from medical theory, exposed individuals report higher rates of diagnosed cardiovascular conditions and higher body mass index (among women). We find no evidence that these results are driven by selective timing of pregnancies, differing survey participation rates, or seasonal effects. JEL Classification: I1, I12, I3, I31, J1, J14
S-cystatin C formulae or combination of s-cystatin C and s-creatinine formulae do not improve prediction of GFR

of the NEPHRIC trial (n = 129 patients), which shows a smaller incidence of contrast-induced nephropathy by using iso-osmolar contrast media [2]. However, we also have not changed our routine daily clinical approach in 2008 by using the low-osmolar contrast media, because the published results were conflicting in the last 2 years. In our paper, we emphasized these conflicting results concerning the value of the osmolality of a contrast media (iso-osmolar versus low-osmolar) in preventing contrastinduced nephropathy by citing three recent trials (RECOVER with n = 300 patients published in 2006, IMPACT with n = 166 patients published in 2006 and CARE with n = 414 patients published in 2007). It was described by the authors of the RECOVER trial, Jo et al., that they indeed found a benefit regarding the composite end-point. Regarding the end-point defined by Aspelin et al. in the NEPHRIC trial, no benefit of the isoosmolar contrast media could be demonstrated [3]. In the IMPACT and the CARE trial there were no different rates of contrast-induced nephropathy by the use of lowversus iso-osmolar contrast media [4,5]. The CARE trial is the most recent and largest, prospective, randomized double-blind trial comparing the iso-osmolar iodixanol370 with the low-osmolar iodixanol-320: when a composite end-point was assessed, the rate of contrast-induced nephropathy was not significantly different (10.3% versus 12.9%) after the administration of the different contrast media [5]. From our point of view, the results are so conflicting that there is no evidence of the superiority of the iso-osmolar versus the low-osmolar contrast media and no firm recommendation based on the overwhelming majority of evidences can be made.
Colloidal AgSbSe2 nanocrystals: surface analysis, electronic doping and processing into thermoelectric nanomaterials

We present a high-yield and scalable colloidal synthesis to produce monodisperse AgSbSe2 nanocrystals (NCs). Using nuclear magnetic resonance (NMR) spectroscopy, we characterized the NC surface chemistry and demonstrate the presence of surfactants in dynamic exchange, which controls the NC growth mechanism. In addition, these NCs were electronically doped by introducing small amounts of bismuth. To demonstrate the technological potential of such processed material, after ligand removal by means of NaNH2, AgSbSe2 NCs were used as building blocks to produce thermoelectric (TE) nanomaterials. A preliminary optimization of the doping concentration resulted in a thermoelectric figure of merit (ZT) of 1.1 at 640 K, which is comparable to the best ZT values obtained with a Pb- and Te-free material in this middle temperature range, with the additional advantage of the high versatility and low cost associated with solution processing technologies.