Miracle-dz/UniFAR-FTUs huggingface dataset:
Preclinical Aspects on Magnetic Iron Oxide Nanoparticles and Their Interventions as Anticancer Agents: Enucleation, Apoptosis and Other Mechanism

The broad area of magnetic iron oxide nanoparticle (M-IONP) applications and their exclusive physico-chemical characteristics (superparamagnetic properties per se , solu-bility and stability in aqueous solutions, and high bioavailability in vivo ) make these nanoparticles suitable candidates for biomedical uses. The most employed magnetic iron oxides in the biomedical field are magnetite and maghemite. Cancer represents a complex pathology that implies multiple mechanisms and signaling pathways, this complexity being responsible for the increased resistance to therapy and the lack of an effective curative treatment. A potential useful alternative was considered to be the use of magnetic iron nanoparticles. The M-IONPs proved to be effective as contrast agents in magnetic resonance imaging, as drug delivery carriers for different therapeutic agents, in magnetic cell separation assays, and are suitable to be engineered in terms of size, targeted delivery and substance release. Moreover, their in vivo administration was considered safe, and recent studies indicated their efficiency as anticancer agents. This chap - ter aims to furnish an overview regarding the physico-chemical properties of M-IONPs (mainly magnetite, maghemite and hematite), the synthesis methods and their in vitro biological impact on healthy and cancer cell lines, by describing their potential mecha- nism of action—enucleation, apoptosis or other mechanisms.
CMP Promoters Database: A systematic study on site-specific transcription factors in CMP genes

CMPP Database (Central Metabolic Pathway Promoter Database) consists of manually annotated regulatory sequences/motif of genes controlling Metabolic Pathways (http://cmpp.biodbs.info) such as Glycolysis’ and Krebs’ cycle. The CMPP software package written in Microsoft Visual Basics & MS Access was also developed for searching & updating the CMPP database. This database was further used to study the relationship between 10 transcription factors involved in the non-coding upstream region of CMP genes. There is an existence of common motifs between the genes encoding enzymes involved in glycolysis and Krebs cycle revealing an evolutionary relation between the genes of the two pathways. However, some of the common motif such as TATA uncommon motifs as NKX and AP2 making up the structural feature of the non coding genes are absent from few genes. Keywords: Non-coding sequence, Phylogeny, TCA, Glycolysis, TRANSFAC, Promoter, Database, Central Metabolic Pathway. Received: 17 March 2008 / Received in revised form: 5 February 2009, Accepted: 31 April 2009 Published online: 14 May 2009
Constructing iterative matching algorithms with the use of Lie theory: three-dimensional orientation example

Iterative algorithms are described for normalizing-coefficient vectors computed by expanding functions on the unit sphere into a series of spherical harmonics. Typical applications of the normalization procedure are the matching of different three-dimensional images, orientation estimations in low-level image processing, or robotics. The method uses general methods from the theory of Lie groups and Lie algebras to linearize the highly nonlinear original problem and can therefore also be adapted to applications involving groups different from the group of three-dimensional rotations. The performance of the algorithm is illustrated with a few experiments involving random coefficient vectors.
New Paradigm or Old Myopia? Unsettling the Communicative Turn in Planning Theory

During the last decade or so, many planning theorists have taken a so-called communicative turn, to the point where somiie have declared the emergence of a dominant new paradigm supported by increasing consensus among theorists. We wish to raise a number of broad questions about the communicative paradigm and claims for its theoretical dominance. We point to alternative analytical positions that focus on issues of power, of the state, and of political economy, in ways that are often underplayed in the communicative literature and that demonstrate a healthy diversity in the field. We offer six critical propositions about communicative planning theory as a contribution to the ongoing debates, in theory and practice, about the conitested nature of planning, its practices and effects.
System Analysis Applied to Autonomy: Application to High-Altitude Long-Endurance Remotely Operated Aircraft

Maturation of intelligent systems technologies and their incorporation into aerial platforms are dictating the development of new analysis tools and incorporation of such tools into existing system analysis methodologies in order to full y capture the trade -offs of autonomy on vehicle and mission success. A first -order “system analysis of autonomy” methodology is outlined in this paper. Further, this analysis methodology is subsequently applied to notional high -altitude long -endurance (H ALE) aerial vehicle missions.
School-visit to a science centre: student interaction with exhibits and the relevance of teachers’ behaviour

This study is centred on the behaviour of students and teachers during a school-visit to a Science Centre, with the purpose to answer to the following research questions: How do the students interact with the exhibits? With whom students interact during the visit? How do the teachers behave during the visit? The study was conducted in two science exhibitions, a permanent one and a temporary one. A total of 52 students and 23 teachers were observed. Data analysis showed that students used to wandering around, interacting with the exhibits for very short periods of time. However, some differences were detected between both exhibitions. In the temporary one, most students seemed to miss the interpretation of the phenomena under observation, just manipulating the exhibits, whereas in the permanent one, they tried to interpret the results of their manipulation. These results can be related to teachers' behaviour. In fact, only in the permanent exhibition teachers remained focused in the visit for almost all the time, manipulating the exhibits while explaining it to students. It is suggested that the role assumed by the teacher during a school visit to a science centre could determine the level of students' engagement with the visit.
How can an Online Community of Practice support New Teacher Development

This research concerns the professional development of teachers in their first year of teaching who were studying the Master of Teaching (MTeach). The research was interested in the views and experiences of the teachers’ participation in the online discussions (ODs) and how this helped them develop. The findings are that the ODs enabled new teachers to participate by writing for an audience of peers, and by providing a sense of community, with an underlying practitioner focus developed their criticality. These new teachers developed a collegiality, reflexivity and an engagement with wider and longer term perspectives. The research concluded that the gains from the ODs were the result of careful pedagogic design. The overarching finding is that by foregrounding the situated experiences and interests of the teachers, a ‘way in’ is provided for them to understand more fully the complexities, dilemmas and strategies encountered in their own and others’ professional practice.
The Relationship between Motivations and Self-Learning and the English Language Achievement in Secondary High School Students

This study aims to determine the level of motivation and relationship of intrinsic and extrinsic motivations and self-learning concerning students’ achievement in the English language, in relevance with their determination and the use of English to derive knowledge and as a medium of communication. A total of 120 secondary high school students in Pekanbaru Riau, Indonesia were randomly chosen as sample to evaluate and determine the influence of internal and external factors, as well as self-learning in mastering the English Language. A set of questionnaire was used in this study to assess the level of students’ motivation and self-learning and its relationship with their achievement. A test was used to measure the level of English proficiency. Pearson correlation and descriptive analysis were used to analyze the findings by using SPSS version 19.0. The findings showed a medium high level of intrinsic motivation, extrinsic motivation and self-learning, whereas students’ achievement was simply at the medium low level. The findings show that there is a less significant relationship between extrinsic motivation and the English Language achievement among students, however there is no significant relationship between intrinsic motivation and self-learning with the achievement. The study also stressed on the importance of providing a supportive learning environment to inspire and encourage students’ interest to form a culture of learning English Language rather than independent learning and intrinsic motivation.
Genetic diversity of the 3ꞌ and 5ꞌ untranslated regions of the HSP70.1 gene between native Turkish and Holstein Friesian cattle breeds

Heat stress proteins are important factors in protecting cells against environmental stress. The HSP70.1 gene is one of the most important members of the heat stress protein family, which is essential for life, production and reproduction. In this study, partial regions of HSP70.1 (3ꞌ and 5ꞌ untranslated regions (UTRs)) were sequenced in six cattle breeds. Blood samples of five native breeds, namely Yerli Kara (YK), Boz irk (BI), Yerli Guney Sarisi (YGS), Guney Dogu Anadolu Kirmizisi (GAK) and Dogu Anadolu Kirmizisi (DAK) were collected from their native regions and blood samples of the Holstein Friesian (Siyah Alaca (SA)) breed were collected from each of these regions. Totals of 249 and 206 animals were analysed for the HSP70.1 - 3ꞌ and 5ꞌ UTR regions, respectively. In the 3ꞌ UTR region, 13 single nucleotide polymorphisms (SNPs) and one indel were found, whereas this region was found to be monomorphic among animals of the Holstein Friesian breed. In the 5ꞌ UTR region, 43 SNPs and three indels were revealed in all of the investigated breeds. On the other hand, a new C983T nucleotide substitution was identified in this region, and is thought to disrupt the Sp1-hsp70 promoter binding site. The 5ꞌ UTR region was also more variable in the Turkish native breeds than in the Holstein Friesian. This study is the first to investigate the 3ꞌ and 5ꞌ UTRs of the HSP70.1 gene in Turkish native breeds. The genetic structure of these gene regions in Turkish native cattle breeds was found to be quite different from those of other cattle breeds that had been studied in the past. Keywords: Bovine, heat shock genes, heat stress, polymorphism
The Relationship between Audit Quality and Earnings Management in Listed Companies in Tehran Stock Exchange

This research aims to investigate the effect of quality of independent audit on profit management in accepted companies in Tehran stock exchange which one main hypothesis and two sub-hypotheses are considered in order to do this purpose and to determine whether there is a relationship between quality of audit and profit management of accepted companies in Tehran stock exchange? According to the assumptions and spatial (which includes the accepted companies in Tehran stock exchange) and temporal domain (2009-2013), data were collected using existing data in the software of rahavard-e-novin and investigating reports and financial statements of accepted companies in Tehran stock exchange by visiting the official website of Tehran stock exchange. The results show that there is a significance relationship between types of audit institution and auditing tenure, profit management.
Occurrence of Pseudomonas syringae pv. garcae in coffee seeds

Given the damage and losses caused by bacterial blight of coffee (Pseudomonas syringae pv. garcae) (PSG) in coffee (Coffea arabica) seedling nurseries and lack of knowledge of the origin of the initial inoculum, the goal of this study was to determine whether coffee seeds can contain viable inoculum and spread bacterial inoculum. Seeds from plants with symptoms of bacterial blight of coffee were immersed in sterilized saline solution, and the crude extract obtained was inoculated in leaves of coffee seedlings. Leaves of plants inoculated with seed extract from symptomatic plants had symptoms of bacterial blight similar to those on leaves inoculated with reference isolate PSG. Seedlings inoculated with seed extract from asymptomatic plants showed no symptoms. Symptomatic leaves were submitted to exudate tests, and the etiologic agent was isolated in culture medium. The isolates with colonies morphologically similar to reference isolate PSG were selected and tested for hypersensitive reaction (HR) and pathogenicity to coffee seedlings. The isolates positive for HR and pathogenic to coffee also showed biochemical and molecular patterns equal to those of reference isolate PSG by the rep-PCR technique using Box primer. Thus, coffee seeds from plants with symptoms of bacterial blight can contain viable inoculum of P. syringae pv. garcae.
Increasing zinc levels in phytase-supplemented diets improves the performance and nutrient utilization of broiler chickens

Three hundred and thirty-six day-old Ross-308 male broiler chicks were used in a 35-day trial to investigate the effect of different concentrations of dietary Zn and phytase on broiler performance and energy utilization. Twelve day-old birds were used for the initial slaughter group to provide baseline body compositional data, while the remaining 324 birds were randomly distributed to six experimental diets. The treatments consisted of a 3 x 2 factorial arrangement with three levels of Zn (low, mid, and high; 30, 40, and 50 mg/kg, respectively) and two levels (0, 500 FTU/kg) of microbial phytase. Each dietary treatment was fed to 6 cages (9 birds/cage). Low Zn diet significantly decreased feed intake and body weight gain at days 1-24. Phytase supplementation improved body weight gain at d 24, irrespective of Zn level. The digestibility of P was improved in birds fed high-Zn diet with phytase supplementation, and the reverse was the case for Fe and Zn digestibility. High dietary Zn increased the Zn and Fe deposition in liver. The activity of AP, Ca-ATPase and Mg-ATPase in the jejunum was high in the phytase supplemented mid-level Zn diet. Phytase supplemented to the mid and high level Zn diets significantly improved most energy utilization parameters. This result indicate that the Zn concentrations used in this study were not inhibitory to phytase activity and broiler performance. Therefore, it can be concluded that dietary zinc level in phytase-supplemented diets could be increased up to 50 mg/kg without any negative effect on phytase-mediated broiler response. Keywords : Bone quality, net energy, nutrient utilization
Unbounded Probability Theory and Its Applications

The paper deals with the order statistics and empirical mathematical expectation (which is also called the estimate of mathematical expectation in the literature) in the case of infinitely increasing random variables. The Kolmogorov concept which he used in the theory of complexity and the relationship with thermodynamics which was pointed out already by Poincar\'e are considered. The mathematical expectation (generalizing the notion of arithmetical mean, which is generally equal to infinity for any increasing sequence of random variables) is compared with the notion of temperature in thermodynamics by using an analog of nonstandard analysis. The relationship with the Van-der-Waals law of corresponding states is shown. Some applications of this concept in economics, in internet information network, and self-teaching systems are considered.
Secret Sharing Schemes Threshold Determination

In threshold secret sharing schemes, the threshold and the total number of shareholders are public information. We believe that such information should be secret and the threshold value must be determined before the secret reconstruction. Thus, this paper propose a method to do it. We propose also, an analysis of tailored access structure that has different subsets to rebuild the secret, each subset with his threshold. Furthermore, in our investigation we have seen that is possible that there are malicious access structures where a previleged subgroup of shareholders, in smaller number than the threshold, can reconstruct the secret. Finally, we propose a method to choose a polynomial that does not generate malicious access structures. Keywords–Secret sharing; threshold; information
Validity of Serum Matrix Metalloproteinase 9 in Diagnosis of Rheumatoid Arthritis: A Case-Control Study from Iraq

Objective: To assess validity of serum matrix metaloprotinase 9 (s.MMP 9) in diagnosis of rheumatoid arthritis (RA) Patients and methods: This case control study was conducted on 50 RA patients ( 10 males and 40 females) diagnosed by a rheumatologist according to American College of Rheumatology (ACR) 1987 revised criteria or ACR- European League Against Rheumatism (EULAR) 2010 Criteria and compared with 25 healthy controls (5 male and 20 female) matched in age and sex. Demographic and clinical characteristics of patients were recorded. S.MMP9 was measured using Enzyme Linked Immunosorbent Assay (ELISA) KIT in both groups. Results: No significant difference between patients and controls in age, sex, and body mass index (BMI) (p>0.05). Serum MMP9 was significantly higher in patients with RA than controls (188.4 ± 24.5 ng/ml vs 21.98 ± 7.87ng/ml, p .0001 and AUC was 1.00) with nearly 100% sensitivity and specificity. At cut-off value ≥34.038 we got the highest sensitivity 100% with specificity 96% and Accuracy 98.7%. And At cut-off value ≥125.479 we had got the highest specificity 100% with sensitivity 98% and Accuracy 98.7%. Conclusions: serum MMP9 was significantly higher in patients with RA than healthy controls. Serum MMP9 was a valid measure to differentiate between RA patients and healthy controls. This may be beneficial for early diagnosis of RA and subsequent a new promising treatment. Keywords: Matrix metalloproteinase 9. Rheumatoid arthritis, inflammatory arthritis, Matrix metalloproteinase
Automated Deviation Analysis for As-Built Status Assessment of Steel Assemblies and Pipe Spools

Steel assemblies and pipe spools play an essential role in the industrial construction sector. Fabrication of steel assemblies has been a challenging task due to the limited fabrication precision of the tools used in the process and inadequate inspection during fabrication. Moreover, unfavorable deformations may occur during the transportation phase which makes the erection and installation phase more complicated. These deviations require further considerations for realignment and repair that are associated with rework on construction sites. Hence, a systematic and automatic framework is required to continuously monitor the fabrication and installation processes of steel assemblies. Current approaches lack a sufficient level of control and are prone to error. This paper presents an automated framework to detect defective parts in steel assemblies and pipe spools in particular. A laser-based point cloud, which represents the as-built status, is compared to the original state from the CAD drawings that exist in the Building Information Model (BIM). Therefore, the defective parts are detected in a timely manner. The comparison is distance based and the procedure is fully automated. The experiments conducted to validate the proposed approach show that the model has high precision and a high rate of recall and has the potential to be employed for automated damage detection in order to improve productivity on construction sites. PROBLEM STATEMENT Steel structural assemblies are one of the critical components in both residential and industrial construction. Pipe spools are also key components for most industrial construction projects such as refineries and power plants. Utilizing steel structural assemblies on construction sites requires accurate fabrication and incident free shipment to site. Due to the advantages that staged fabrication of modules provides such as a controlled environment for fabrication, improved safety and improved
Costs of Enforcement in Developing Countries with Credit Market Imperfections

This paper examines development processes of a country when the degree of verifiability is endogenously determined. We characterize the development processes rigorously and show that although the efforts for improving of verifiability are important, the income distribution of a country is crucial for the effectiveness of efforts to the development processes. Moreover, this paper explains the situation where one country shows high growth rates temporally even if the technology of enforcement is poor, but eventually it experiences economic collapses.
AIS Electronic Library (AISeL)

Trust is an essential component for any business transaction, and is particularly critical and challenging in the online environment, which is characterized by a de-humanized interface. In this paper the concept of humanized Website design is introduced as a potential trust instiller with online customers. The validity of this concept is investigated within the framework of an online trust model which distinguishes between product, company and referee trust. An empirical study is outlined
The Impact of Climate Change on Agricultural Output in South Africa (1997-2012)

South Africa has shown major interest in the climate change discourse since the Kyoto Protocol in 1997. Climate change has moved from an issue of environmental concern to an issue of commercial significance. The purpose of this study was to investigate the impact of climate change on agriculture output in South Africa. The impact of climate change on output is examined in this study using the ordinary least squares (OLS) method. The estimated econometric model regresses temperature, rainfall, labour and capital on GDP in the agricultural sector. The results suggest that there is a negative relationship between climate change and agricultural output in South Africa.