Miracle-dz/UniFAR-FTUs huggingface dataset:
HPV 16 E 5 is produced from an HPV 16 early mRNA spliced from SD 226 to SA 3358 Running title : Translation of HPV 16 E 5 mRNAs

The HPV16 E5 open reading frame (ORF) is present on the majority of all alternatively spliced HPV16 mRNAs, but it is currently unknown how well it is translated into E5 protein. To identify HPV16 mRNAs that are efficiently translated into E5, we have generated cDNA plasmids expressing individual, alternatively spliced HPV16 mRNAs with the potential to produce E5. By replacing the E5 ORF with sLuc, we could quantitate sLuc and determine how well each cDNA was translated. Our results showed that the upstream E1 and E7 AUGs inhibited translation of the E5 ORF and revealed that only one HPV16 mRNA produced high levels of E5. This was an HPV16 early mRNA spliced from SD226 to SA3358. These results were confirmed in the context of the entire HPV16 genome. Taken together, our results indicate that E5 is expressed early in the HPV16 replication cycle since it is translated efficiently only by one early mRNA.
Stay Cool, Hang Loose, Admit Nothing: Race, Intergroup Contact, and Public-Police Relations

Drawing on the contact hypothesis of Allport (1954) and Pettigrew (1998) we examined whether public-police contact, among White and Black university students in Britain, mediated between participant race and perceived racism of police and cooperation with police, respectively. Study 1 (N = 105) showed this to be the case for quality, but not quantity of contact. High-quality contact mitigated the negative effects of being Black on greater perceived racism and lower cooperation. Study 2 (N = 130) assessed a general view of police and desired closeness to police as dependent variables and investigated the moderating potential of racial identification. Higher-quality and lower quantity of contact were associated with a more positive view of police and higher desired closeness. Identification moderated the effects of race on quantity of contact, view of police, and desired closeness, with negative effects driven by high identification.
Highlights : DR protects against acute stress associated with heart attack , stroke and organ transplantation

Reduced caloric intake including fasting, as well as the dietary composition or the timing of food intake impact longevity, likely through a modification in the onset or the severity of chronic aging-related diseases such as cancer. As with preand post-operative dietary recommendations, evidence-based nutritional advice from healthcare professionals during and after cancer treatment is often vague or conflicting. We hypothesize that preventive dietary recommendations can help in the context of both chronic cancer treatment efficacy and the avoidance of development of secondary malignancies, as well as in the context of protection from the acute stress of surgery. In this perspective review, we will discuss the latest findings on the potential role of short-term dietary restriction in cancer treatment and improvement of surgical outcome.
A Continuous-Time Model for Valuing Foreign Exchange Options

This paper makes use of stochastic calculus to develop a continuous-time model for valuing European options on foreign exchange (FX) when both domestic and foreign spot rates follow a generalized Wiener process. Using the dollar/euro exchange rate as input for parameter estimation and employing our FX option model as a yardstick, we find that the traditional Garman-Kohlhagen FX option model, which assumes constant spot rates, values incorrectly calls and puts for different values of the ratio of exchange rate to exercise price. Specifically, it undervalues calls when the ratio is between 0.70 and 1.08, and it overvalues calls when the ratio is between 1.18 and 1.30, whereas it overvalues puts when the ratio is between 0.70 and 0.82, and it undervalues puts when the ratio is between 0.86 and 1.30.
Technological aspects of public tourism communication in Italy

Purpose – The purpose of this paper is to evaluate the online presence of Italian destination management organizations (DMOs) by assessing the quality of their web sites through a demand‐side heuristic approach. Moreover, given the importance of a clear strategic vision for an efficient and effective use of online media, the paper examines the alignment between tourism development plans and practical implementation of information and communication technologies (ICT). Finally, the possible impact of the adoption of a strategic approach on the overall quality of the web sites under investigation is explored.Design/methodology/approach – A double analysis was conducted. An assessment of the main quality features of the official tourism web sites and an evaluation of the statements of public authorities concerning strategic intentions and guidelines for developing ICT instruments. The two evaluations are compared in order to examine their relationships. A strategic matrix of the technological performance and .
Laser (U‐Th)/He thermochronology of detrital zircons as a tool for studying surface processes in modern catchments

Detrital mineral thermochronology of modern sediments is a valuable tool for interrogating landscape evolution. Detrital zircon (U‐Th)/He thermochronology is of particular interest because zircons are durable and withstand transport in glacial and fluvial systems far better than, for example, apatite. However, because of the time‐intensive nature of conventional zircon (U‐Th)/He thermochronology, most previous studies of this kind have relied on data for a few tens of grains, even though conventional wisdom holds that a substantially larger number is necessary for a robust characterization of the population of cooling ages in a sample. Here, we introduce a microanalytical approach to detrital zircon (U‐Th)/He thermochronology that addresses many factors that can complicate the interpretation of conventional zircon (U‐Th)/He data, particularly with respect to alpha ejection and injection and U + Th zoning. In addition, this technique permits the effective dating of naturally abraded and broken grains, and, therefore, lessens the potential for sampling bias. We apply both conventional and laser microprobe techniques to a detrital sample from the Ladakh Range in the northwestern Indian Himalaya, showing that the two yield very similar principal modes of apparent ages. However, the laser microprobe data yield a broader spectrum of ages than that of the conventional data set, which we interpret to be caused by bias related to the selection requirements for zircons used for conventional dating. This method thus provides a time‐efficient route to obtaining a higher‐resolution distribution of dates from a single sample, which will, in turn, yield higher‐fidelity constraints regarding catchment‐wide erosion rates for surface process studies.
Quality of poultry litter submitted to different treatments in five consecutive flocks

It was evaluated the effects of poultry litter treatment on moisture content, pH, density and volatilized ammonia for five consecutive flocks of broiler chicken breeding. It was used 640 birds per flock as a complete randomized design with eight treatments and four replicates. The treatments were the following: 1 non-treated litter; 2 litter submitted to in-house composting; 3 litter treated with aluminum sulfate; 4 litter submitted to gypsum; 5 litter treated with quicklime; 6 litter treated with dolomitic limestone; 7 litter treated with zeolite and 8 litter treated with charcoal. Chopped elephant-grass hay was used as poultry litter in all flocks. Fermentation in the shed increased moisture content of the litters in the second and first flocks on 21 and 42 days of breeding, respectively. There was no difference on density among treatments. Aluminum sulfate reduced pH of the litters in all flocks at 21 days of breding. On 42 days of breeding, pH of the litters was reduced in the litters with aluminum sulfate and gypsum in the first, second and forth flocks. On 21 days, aluminum sulfate reduced the volatilized ammonia in the first, third and forth flocks, and on 42 days, there was a reduction of volatilized ammonia in the litters with aluminum sulfate in the forth flock. Aluminum sulfate can improve quality of poultry litter of chopped elephant-grass hay by reducing pH and ammonia volatilization.
Feasibility of Using Event Data Recorders to Characterize the Pre-Crash Behavior of Drivers in Rear-End Collisions

This paper investigates the feasibility of using event data recorders (EDRs) to characterize the crash avoidance behavior of drivers involved in rear end collisions. The study is based upon the records of 112 crashes from NASS/CDS 2000-2007 with associated EDR pre-crash data and of sufficient severity to deploy the frontal air bag. The study examined three factors affecting driver response to an impending rear collision: driver age, driver alcohol use, and road lighting condition. Crash avoidance actions of the drivers were inferred from the pre-crash EDR records of vehicle speed, throttle position, engine speed (RPM), and service brake status five seconds prior to impact. Factors considered included time of brake application prior to impact, peak braking deceleration, and the time history of throttle position. For these cases, this study combined EDR pre-crash records with NASS/CDS case records including scene diagrams and site photos to determine driver crash avoidance actions. The full text of this paper may be found at: http://www-nrd.nhtsa. dot.gov/pdf/esv/esv21/TOC.pdf For the covering abstract see ITRD E145407.
eview ging and HIV infection ivian

Introduction: Population aging has become a global phenomenon, and HIV infection among older individuals is also increasing. Because age can affect the progression of HIV infection, we aimed to evaluate the present knowledge on HIV infection in older patients. Methods: Literature review of the last 20 years. Results: Older HIV-infected patients have lower CD4+ T cell counts, higher viral load and are more frequently symptomatic at diagnosis. The infection progresses more rapidly, with higher morbidity and lethality rates. However, older patients are more compliant to antiretroviral treatment; they experience a better virologic response, and treatment represents a positive clinical impact. Aging affects the complex interaction between HIV infection and the immune system. Both conditions contribute to the dysfunction of immune cells, including a decrease in the phagocytes’ microbicidal capability, natural killer cells’ cytolytic function, expression of toll-like receptors and production of interleukin-12. Chronic immune activation responsible for the depletion of CD4+ and CD8+ T cells in HIV infection appears to worsen with senescence. Older patients also exhibit a less robust humoral response, with the production of less avid and specific antibodies. Conclusion: Both HIV and aging contribute to immune dysfunction, morbidity and mortality. However, highly active antiretroviral therapy (HAART) is beneficial for older patients, and treatment of older patients should not be discouraged.
UvA-DARE ( Digital Academic Repository ) Homeobox genes in neuroblastoma

A large proportion of patients suffering from the malignant pediatric tumor neuroblastoma die of progressive disease despite intensive therapy. Neuroblastomas belong to the group of neuroblastic tumors, together with more differentiated ganglioneuroblastomas and benign ganglioneuromas. Little is known of the genes driving the differentiation processes in these tumor types. A search for the transcription factors differentially expressed between ganglioneuromas, ganglioneuroblastomas, and neuroblastomas in a series of 110 neuroblastic tumors (NB110) identified a large number of HOXand TALE (Three Amino acid Loop Extension)-class homeobox transcription factor genes. The MEIS1-3, PBX1 and -3, and PKNOX1 TALE genes showed highest expression in neuroblastomas and lowest in ganglioneuromas and ganglioneuroblastomas. The PKNOX2 and TGIF1-2 genes showed the opposite expression pattern. This suggests an involvement of TALE genes in neuroblastoma differentiation. Expression of MEIS1, a known oncogene in haematopoietic tumors, was high in all neuroblastomas, and strongly correlated with undifferentiated histology. Consequently we generated IMR-32 neuroblastoma cells capable of inducible shRNA-mediated MEIS1 knockdown. We observed differentiation, growth arrest and induction of apoptosis upon MEIS1 down-regulation. Affymetrix profiling of time-course experiments using these cells allowed the identification of MEIS1 target genes. Analysis of the target genes in the NB110 series showed that 323 of these were also significantly correlated to MEIS1 expression and to tumor differentiation in neuroblastic tumors. Genes involved in the cell cycle and in developmental pathways were over-represented in this gene set. We conclude that MEIS1 governs several of the signal transduction routes important for neuroblastoma survival and differentiation.
A four-dimensional time–space trend model to be applied in the reconstruction of former sea levels and ice-front recession

Dating ice-front recession by means of late-glacial shoreline diagrams is a classical method in Quaternary geology. In Nonvegian fjord areas this was the most common method of dating ice-front recession chronology before the introduction of the radiocarbon dating method. The shoreline diagram has been used to correlate characteristic events in sea level and ice-front recession chronology on a relative time scale. The major inconveniences of this method are the relative time scale, a coarse time resolution and projection problems in the construction of the diagram.
Low-Power Ultrasonic Wake-Up and Communication through Structural Elements

Research in ultra-low energy communication for wireless sensor networks mostly focuses on radio frequency (RF). Simple, low-cost, and low-power approaches for acoustic communication are typically not explored, although in a variety of applications acoustic communication using ultrasonic waves is preferable to RF. In others, motes are already equipped with sensors and actuators for acoustics. In this work, we present a method to communicate between motes on structural elements using piezoelectric discs. We demonstrate that data rates up to one kilobit per second are achievable with only minimal additional hardware. At the same time, the energy consumption for communication is reduced compared with popular RF methods.
Catch me if you can: how geo-indistinguishability affects utility in mobility-based geographic datasets

This paper sheds light on the trade-offs between privacy and utility in mobility-based geographic datasets. We aim at finding out whether it is possible to protect the privacy of the users in a dataset while, at the same time, maintaining intact the utility of the information that it contains. In particular, we focus on geo-indistinguishability as a privacy-preserving sanitization methodology, and we evaluate its effects on the utility of the Geolife dataset. We test the sanitized dataset in two real world scenarios: 1. Deploying an infrastructure of WiFi hotspots to offload the mobile traffic of users living, working, or commuting in a wide geographic area; 2. Simulating the spreading of a gossip-based epidemic as the outcome of a device-to-device communication protocol. We show the extent to which the current geo-indistinguishability techniques trade privacy for utility in real world applications and we focus on their effects at the levels of the population as a whole and of single individuals.
leukocytoklastyczne zapalenie naczyń ( vasculitis allergica , vasculitis leukocytoclastica )

Adres do korespondencji: prof. dr hab. med. Jadwiga Roszkiewicz Katedra i Klinika Dermatologii, Wenerologii i Alergologii Akademia Medyczna w Gdańsku ul. Dębinki 7, 80–211 Gdańsk e-mail: jrosz@amg.gd. pl STRESZCZENIE Lekarz dermatolog spotyka się dość często z różnymi zmianami krwotocznymi na skórze, u podłoża których, jak wykazuje badanie histologiczne, leżą zmiany martwiczo-zapalne drobnych naczyń krwionośnych, określane najczęściej jako: purpura hyperergica, vasculitis allergica, necrotica lub vasculitis leukocytoclastica. Zmiany te dotyczą naczyń włosowatych, drobnych naczyń żylnych oraz arterioli i polegają na procesie zapalnym ścian tych naczyń z odkładaniem się w nich immunoglobulin i komplementu. Proces ten często prowadzi do tworzenia wewnątrznaczyniowych zakrzepów i ognisk martwicy włóknikowatej ścian naczyń, czemu towarzyszy naciek zapalny ściany i otoczenia naczynia, złożony głównie z neutrofili z obecnością fragmentów jąder (leukocytoclasia). Wśród czynników wywołujących wymienia się infekcje, leki, obce białko, niektóre środki chemiczne, układowe choroby tkanki łącznej, ukąszenia owadów, nowotwory. W ponad połowie przypadków choroba ma tło idiopatyczne. Krwotoczne zmiany skórne mogą niekiedy wyprzedzać lub towarzyszyć zmianom w narządach wewnętrznych (zwłaszcza w nerkach), a dalsze losy chorego zależą wówczas od właściwego wczesnego rozpoznania i leczenia.
Abbreviated title : Anatomy of the beetle central complex

Despite their tiny brains, insects show impressive abilities when navigating over short distances during path integration or during migration over thousands of kilometers across entire continents. Celestial compass cues often play an important role as references during navigation. In contrast to many other insects, South African dung beetles rely exclusively on celestial cues for visual reference during orientation. After finding a dung pile, these animals cut off a piece of dung from the pat, shape it into a ball and roll it away along a straight path until a suitable place for underground consumption is found. To maintain a constant bearing, a brain region in the beetle’s brain, called the central complex, is crucially involved in the processing of skylight cues, similar to what has already been shown for path-integrating and migrating insects. In this study, we characterized the neuroanatomy of the sky-compass network and the central complex in the dung beetle brain in detail. Using tracer injections, combined with imaging and 3D modelling, we describe the anatomy of the possible sky-compass network in the central brain. We used a quantitative approach to study the central-complex network and found that several types of neuron exhibit a highly organized connectivity pattern. The architecture of the skyA cc ep te d A rti cl e
Share What and How You Cook at Home! : Uncovering Social Identity

the passion for food and cooking establishes new social identity. There is a trend in social media usage where people share how and what they cook at home. There are also some applications that enable people to develop, experience and innovate their cooking skills. The aim of this study is to present how, why and what people's cooking activities are being shared through applications (apps), and its marketing implication. The investigation conducted through qualitative exploratory method. The findings are food and cooking could bring social cohesion and create social images that refer to certain groups or cultures and to certain extend create new groups and culture within the society. This study also finds that the extensive usage of apps by social groups creates opportunities for new marketing strategies to emerge, namely mobile advertising.
Critical Reviews in Food Science and Nutrition

Proanthocyanidins (PAs) are a class of oligomeric flavonoids found in a variety of plant foods. Intake of PAs in human diet has been associated with a reduced occurrence of various chronic disorders. Cereal and pseudocereal grains are staple food items. Grain genotypes containing PAs can be developed as functional foods to efficiently improve human health. This review summarises the occurrence of PAs in diverse grains, including rice, wheat, barley, sorghum, millets, buckwheat, and some forage grasses. Great diversity in PA structure and composition has been recorded. The biological activities of the grain PAs, such as antioxidant, antiinflammatory, anticancer, and antidiabetic capacities, are also reviewed. The bioavailability and metabolism of grain PAs in human digestive tract are discussed. Future research directions are suggested on how to improve our understandings of the chemistry of PAs in cereals and pseudocereals and of the biological properties for human health applications.
Sowers Diabetes Mellitus and Vascular Disease

Diabetes Mellitus and Vascular Disease Print ISSN: 0194-911X. Online ISSN: 1524-4563 Copyright © 2013 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Hypertension doi: 10.1161/HYPERTENSIONAHA.111. 00612 2013;61:943-947 Hypertension. http://hyper.ahajournals. org/content/61/5/943 World Wide Web at: The online version of this article, along with updated information and services, is located on the
Genetic variability in Grapevine virus A from Vitis vinifera L. × Vitis labrusca L. in Sichuan, China

Grapevine virus A (GVA) has a quasispecies nature and is closely associated with the rugose-wood disease complex of Vitis vinifera L. In the different growing regions of table grape in Sichuan, southwest China, the incidence of GVA infection was found to be 16.9% by ELISA detection among 178 grape plants (Vitis vinifera L. × Vitis labrusca L.). The results of restriction fragment length polymorphism (RFLP) studies on the polymerase chain reaction (PCR) products of a total of 139 plasmids, cloned from 15 GVA isolates, suggested that the GVA isolates contained highly divergent variants. The plasmids from each GVA isolate that yielded different PCR-RFLP profiles were preferentially chosen for sequencing and were designated as variants. Furthermore, a phylogenetic study based on the analysis of the GVA coat protein genes and RNA silencing suppressor genes showed that the 40 variants obtained from the 15 GVA isolates represented 4 clades, designated as molecular groups I, II, III, and IV, respectively. The variant-specific PCR detection results indicated that the parts of the tested grape plants were specifically infected by mild variants.
A MONOLITHIC PASSIVE CHECK-VALVE FOR SYSTEMATIC CONTROL OF TEMPORAL ACTUATION IN MICROFLUIDIC DEVICES

This work describes the design and application of a microfluidic check-valve, made solely of poly(dimethylsiloxane), capable of passively controlling pressurized fluids. The integrated check-valve is designed to only allow forward-flow at certain threshold pressures and to negate both back-flow and diffusion when in a closed state. The required threshold pressures are directly related to the valve’s geometry and therefore can be adjusted. We demonstrate that these valves are able to act similarly to a transistor and linked-up in a specific fashion to passively switch between simultaneously infused fluids. This shows the ability to create predefined passively controlled microfluidic systems.
Title : Relative Contributions and Mapping of Ventral Tegmental Area Dopamine and GABA Neurons by Projection Target in the Rat Running Title : Mapping of VTA neurons by projection

Peter Fong’s present address is: Touro University California, College of Osteopathic Medicine, Vallejo, California 94592; Patricia Himmels’s present address is: Genentech Inc. 1 DNA Way, South San Francisco, California 94080; Elayne Dias’s present address is: Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil 13083-865; and Hagar Lock’s present address is: Calle Alonso Cano 11D, Bellaterra, Barcelona, Spain, 08193