Miracle-dz/UniFAR-FTUs huggingface dataset:
AN INVESTIGATION ON PREDICTORS OF STUDENT ACADEMIC ENGAGEMENT

This study investigated: 1) senior high school students’ academic engagement; 2) factors predicting their academic engagement. The sample for this study included senior high school students from two different contexts: Vientiane capital and Luangprabang. A purposive sampling technique was used. The study employed a convergent parallel design. Both quantitative and qualitative were collected simultaneously through questionnaires, interviews, and observations. This study analyzed for percentage, mean, and standard deviation, and conducted a content analysis. The results showed that most of the students hold a high level of engagement in all three dimensions (emotional, behavioral, and cognitive). The behavioral and emotional dimensions had the highest engagement scores ( = 3.45; = 3.42 ) , showing that the students in the sample are likely to be engaged in learning behaviorally and emotionally. Furthermore, the study found that teacher and peer interaction are the most powerful factors predicting their academic engagement. Most of the students consider the kindness and friendliness of teachers to be important for their engagement. Moreover, the students in the sample also indicate that they are more engaged in learning if teachers provide opportunities to have discussions with peers. To implement a good teaching and learning environment in high school levels, and especially to promote senior high school students’ learning engagement, administrators should consider creating a close follow-up plan on teacher professional development activities, which could help ensure the quality of teaching in schools. In addition, it is recommended that school leaders integrate more extra-curricular activities, as well as more opportunities for parent/guardian participation. Article visualizations:
Array Beampattern Synthesis Without Specifying Lobe Level Masks

In this article, we devise a novel array beampattern synthesis algorithm, namely, without lobe level mask (WLLM), to avoid specifying a possibly improper or infeasible pattern mask by minimizing the ratio of the maximal sidelobe level to the minimal mainlobe level. To solve the resultant nonconvex and nonlinear fractional programming, we introduce auxiliary exponent variables to separate the numerator and denominator, and simplify each of the corresponding subproblems as a special single-variable optimization problem with a piecewise objective function and the constraints are removed via introducing unit-step functions. We also analyze the convexity or concavity of each piecewise function to compute the corresponding local minimum from which the global minimum can be obtained. Furthermore, our developed method is extended for solving the phase-only and constant modulus pattern synthesis problems. Numerical examples show that the WLLM beampattern synthesis methods can attain sufficiently low sidelobe level relative to the mainlobe level and is suitable for arbitrary array configurations.
Are students really overloaded

The ongoing reform of higher education in Lithuania is aimed at improving the quality of studies. The main actor of this process is a student, and the quality of studies depends mainly on his/her motivation to obtain knowledge and skills. The aim of the research was to analyse the patterns of studying, gaining knowledge, and acquiring skills in second-year students at Kaunas University of Technology, the Faculty of Social Sciences. The survey was carried out in 2008 in the fall semester. Diaries were received from 209 students. The diary used for data collection was adapted in 2004 by Statistics Lithuania in accordance to EUROSTAT Guidelines on Harmonised European Time Use Surveys. Data analysis was performed separating diary days to weekdays (150 respondents) and weekend-days (59 respondents). The results of the analysis showed that during weekdays, 44.3% of an average diary day is spent for personal care (including sleep), 15% – for studying, 8.9% – for travel, 8.2% – for domestic work, 7.4% – for leisure, etc. During weekend-days, the distribution of diary day was as follows: 50.2% of the time was spent for personal care, 9% – for domestic work, 6.9% – for travel, 10.1% – for leisure, 6% – for studying, etc. The main conclusions drawn from the research are: a) only the time of classes, lectures, and homework (and none of the free time) is devoted to studying; b) efforts are needed to change priorities of time use during university studies in Lithuania.
Cognitive Changes after Saline or Plasmalyte Infusion in Healthy Volunteers A Multiple Blinded, Randomized, Cross-over Trial

ABSTRACTBackground: In an incidental finding, during a study of plasma chemistry after crystalloid infusion, participants reported subjective cognitive changes, particularly slower thinking, after saline but not Hartmann’s (Ringer’s lactate) solution. The authors tested the hypothesis that saline infu-sion would produce greater adverse cognitive changes than Plasmalyte infusion. Methods: The authors conducted a randomized, cross-over, multiple blinded study of healthy adult volunteers. On sepa-rate days, participants received 30ml/kg over 1 h of either 0.9% saline or Plasmalyte with the order randomly allo-cated. Plasma chemistry was tested on venous samples. As part of a battery of cognitive tests our primary endpoint was the reaction time index after infusion. Results: The authors studied 25 participants. Plasma chloride was greater after saline than after Plasmalyte: mean difference 5.4 mM (95% CI, 4.1–6.6 mM; P < 0.001). Saline was also associated with greater metabolic acidosis: base-excess 2.5 mM more negative (95% CI, 1.9–3.0 mM more negative;
Development of Less Toxic Treatment Strategies for Metastatic and Drug-Resistant Breast Cancer Using Noninvasive Optical Monitoring

Abstract : This project involves the development of optically guided multi-agent therapies for metastatic and drug resistant breast cancer. Non-invasive Diffuse Optical Imaging technologies are able to monitor drug response and resistance through quantitative tracking of tumor metabolism and vascular supply, using clinic friendly and portable devices that can monitor deep lesions (multiple centimeters below the skin) in both breast tissue and at the site of bone metastases. During year 1 of the project we have received institutional IACUC approval as well as ACURO approval. We have successfully set up a new long wavelength intravital multiphoton microscopy system that will be important for future work on the project. We have conducted initial in vivo and ex vivo mouse imaging experiments with the system. We have also fabricated a new long wavelength Spatial Frequency Domain Imaging (SFDI) small animal imaging system and demonstrated imagining capability up to 1300 nm for the first time, which will allow for deep tissue extractions of hemoglobin, lipid, and collagen concentrations.
Original article Nutritional value, functional properties and nutraceutical applications of black cumin (Nigella sativa L.): an overview

Summary Non-conventional seeds are being considered because their constituents have unique chemical properties and may augment the supply of nutritional and functional products. Black cumin (Nigella sativa L.) seeds and its crude or essential oils have been widely used in traditional nutritional and medicinal applications. Consequently, black cumin has been extensively studied for its nutritional value and biological activities. The black cumin oilseed had been shown to be anticancer, antidiabetic, antiradical and immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, bronchodilator, hepatoprotective, antihypertensive and renal protective. Moreover, black seeds have many antioxidative properties and activities. In consideration of potential utilisation, detailed knowledge on the composition of black cumin oilseed is of major importance. The diversity of applications to which black cumin can be put gives this oilseed great industrial importance. This review summarises the nutritional value, functional properties and nutraceutical applications of black cumin (N. sativa L.) oilseeds.
Digital communications and social media use in surgery: how to maximize communication in the digital age

Abstract Communication among patients, colleagues, and staff in healthcare has changed dramatically in the last decade. Digital technology and social media sites have allowed instantaneous access to information. The potential for information technology to improve access to healthcare, enhance the quality, and lower the cost is significant. Text messaging, tweeting, chatting, and blogging are rapidly replacing e-mail as the preferred means of communication in healthcare. This review will highlight how digital technology is changing the way surgeons communicate with colleagues and patients as well as provide some guidance as to how to avoid some of the pitfalls and problems that this form of communication can bring.
Presence of Celiac Disease in Type 1 Diabetic Patients Presenting at Jinnah Hospital, Lahore

Introduction Genetically susceptible persons develop Celiac disease (CD) and multiple factors are involved in its causation, basic underlined pathology involves autoimmunity. CD is stimulated by a various environmental factors and among the related factors, gluten prolamins are the major risks resulting in generation of anti-tissue transglutaminase which act as auto-antigen. CD target is small intestine, resulting inflattening of small intestinal mucosa over a period of time. Wheat, rye, and barleycontain gluten and are hazardous for patients with CD (1) especially having type 1 diabetes . CD is a spectrum ranging from no clinical sign and symptoms to full blown malabsorption syndrome leading to weight loss diarrhea, micro nutrient
ПРОГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ ДЕЛЕЦИИ ЛОКУСА ГЕНА CDKN2A/9p21 У ВЗРОСЛЫХ ПАЦИЕНТОВ С Ph-НЕГАТИВНЫМ ОСТРЫМ ЛИМФОБЛАСТНЫМ ЛЕЙКОЗОМ НА ТЕРАПИИ ПО ПРОТОКОЛУ ОЛЛ-2009

Introduction. CDKN2A deletion is a frequent cytogenetic abnormality in acute lymphoblastic leukemia (ALL), ranging from 18 to 46 %, associating with Т-cell ALL, high WBC counts, splenomegaly, lymphadenopathy. In pediatric group of patient’s CDKN2A deletion was associated with poor event-free survival. The prognostic impact of CDKN2A deletion in adult ALL patients appear controversial. The aim of this study was to evaluate the prognostic impact of the CDKN2A deletion in adult patients with acute lymphoblastic leukemia, which were treated by RALL-2009. Materials and methods. We present the results of the CDKN2A deletion in 110 adult patients with newly diagnosed Ph-negative (Ph‒) ALL, which were treated by RALL-2009 (NCT01193933) since June 2009 till September 2016. Patients characteristics: the median age was 26 years (range 15–54), 65 (59 %) of the 110 patients had a B-precursor phenotype, 42 (38 %) had a T-cell phenotype, 3 (2.7 %) patients – biphenotypical ALL. Interphase fluorescence in situ hybridization (FISH) was performed for detection CDKN2A deletion, MLL, с-MYC rearrangement, TP53 deletion, t (1;19) (q23; p13.3)/TCF3-PBX1, t (12;21) (p13.2; q22.1)/ETV6-RUNX1 and iAMP21. The median follow-up was 31 months (0.5 to 80 months). Results. The prevalence of the CDKN2A deletion in all studied population was 24.3 % (27 cases). Our study demonstrated that CDKN2A deletion had no significant association with age, sex and blast cells immunophenotype. The analysis for T-ALL has detected that CDKN2A deletion was strongly associated with high WBC count (the median is 86 × 109/L; p = 0.006) and with high lactate dehydrogenase level (the median is 3062 IU; p = 0.0004). But in BCP-ALL cases similar correlation was not found. CDKN2A deletion didn’t have statistically significant impact on outcome of patients. OS for patients with BCP-ALL with and without deletion was 85 and 76 % (p = 0.35); DFS was 92 and 65 % (p = 0.07), respectively. OS for T-ALL patients with and without deletion was 90 and 80 % (p = 0.63); DFS was 100 and 82 % (p = 0.24), respectively. Conclusion: CDKN2A deletion is not adverse prognostic factor in adult ALL patients treated according to protocol RALL-2009.
THU0330 Mycobacterial cord factor analog induces high il-6 secretion and mincle receptor expression in patients with takayasu arteritis

Background Association between Takayasu Arteritis (TA) and Tubcerculosis (TB) has been in vogue for years. Scientific evidence for this association is limited. Objectives To study pro-inflammatory cytokine responses and mRNA expression in patients with TA on exposure to Trehalose-6,6-dibehenate (TDB), a synthetic analogue of mycobacterial cord factor in comparison with healthy controls. Methods Patients with type V TA satisfying 1990 ACR criteria and age and sex matched healthy controls were recruited. 10 ml blood was collected in heparin coated tube. PBMCs were separated by density gradient centrifugation. PBMCs were cultured with and without 5μg/ml and/or 50 μg/ml of TDB for 48 hours in RPMI medium at 5% co2 incubator. IL-6, TNF-αand IL-17 were measured in cell culture supernatant. RNA was extracted from the cells and quantification of gene expression was performed using sequence specific primers with SYBR green in Step One Plus™ Real-Time PCR Systems (Applied Biosystems). Results Twenty two TA patients and 21 age and sex matched healthy controls were recruited. Baseline characteristic of cases included median (range) age:26.5 years (15–49), male:femaleratio of 5:17, ITAS-CRP2010: 7 (1–26) and DEITAK: 7.5 (1–21). Both patients and controls showed response by secreting IL-6 and TNF-α upon stimulation withTDB. Relative induction of IL-6 was significantly higher in TA [31.88 (0.74–168)] as compared to healthy controls [1.931 (0.644–8.21); p<0.002]. IL-17 was undetectable even upon TDB stimulation. Relative mincle expression was significantly upregulated by TDB in TA1.03 (0.623–1.346) fold, as compared to healthy controls 0.43 (0.36–0.57) fold (p<0.05). Relative gene expressions of IL-6, IL-8, TNFα, IFN-gand BCL-10 were not significantly different between TA and healthy controls. Conclusions Stimulation with TDB led to higher secretion of IL-6 and increased mincle expression in PBMCs of TA patients as compared to healthy controls. Disclosure of Interest None declared
CLINICAL APPLICATION OF BONE MORPHOGENETIC PROTEIN ON FRACTURE HEALING PROCESS

Pada proses penyembuhan fraktur, sering terjadi delayed union maupun non-union. Penggunaan Bone Morphogenetic Proteins (BMP) menjadi salah satu solusi untuk masalah ini. Beberapa penelitian membuktikan bahwa BMP membantu meningkatkan regenerasi penyembuhan fraktur dengan kasus sulit pada sejumlah pasien. Tinjauan pustaka ini membahas pengenalan BMP dan efisiensi daripada penggunaan klinis BMP. Saat ini, rhBMP-2 dan rhBMP-7 menunjukkan hasil klinis yang signifikan namun subfamili BMP lainnya masih dalam penelitian.
Neural Networks for Natural Language Processing

We present in this chapter an original LSTM-based architecture, named Parallel LSTM (PLSTM), that carries out multiple parallel synchronized input sequences in order to predict a common output. The proposed PLSTM could be used for parallel sequence classification purposes. The PLSTM approach is evaluated on the automatic telecast genre sequences classification task. Results show that the proposed PLSTM method outperforms the baseline n-gram models as well as the state-of-the-art LSTM approach. This chapter corresponds to part of the work done during Mohamed Bouaziz’s Ph.D. thesis, in CIFRE convention with the company EDD and co-supervised by Georges Lianrès (LIA), Richard Dufour (LIA) and myself between September 2013 and December 2017.
A New approximate matching compression algorithm for DNA sequences

Undeveloped countries like Guatemala, where access to high-speed internet connections is limited, downloading and sharing Biological information of thousands of Mega Bits is a huge problem for the beginning and development of Bioinformatics. Based on that information is an urgent necessity to find a better way to share this biological data. There is when the compression algorithms become relevant. With all this information in mind, born the idea of creating a new algorithm using redundancy and approximate selection. Methods: Using the probability given by the transition matrix of the three-word tuple and relative frequencies. Calculating the relative and total frequencies given by the permutation formula (nr) and compressing 6 bits of information into 1 implementing the ASCII table code (0…255 characters, 28), using clusters of 102 DNA bases compacted into 17 string sequences. For decompressing, the inverse process must be done, except that the triplets must be selected randomly (or use a matrix dictionary, 4102). Conclusion: The compression algorithm has a better compression ratio than LZW and Huffman’s algorithm. However, the time needed for decompressing makes this algorithm incompatible for massive data. The functionality as MD5sum need more research but is a promising helpful tool for DNA checking.
Intervenção educativa sobre parada cardiorrespiratória intra-hospitalar: conhecimento dos profissionais de enfermagem de unidades médico-cirúrgicas

The present study aimed to assess the effect of an educational intervention about cardiorespiratory arrest in the theoretical knowledge of nursing professionals in medical-surgical hospitalization units. This is a quasi-experimental study, developed with professionals working in two admission units from a public university hospital in Parana state. As an educational intervention, we conducted theoretical-practical training. We applied a questionnaire before and after training. We considered p values <0.05 as significant. Of the 47 professionals who worked in these units, 37 (78.72%) participated in the pre-test and, 32 (68.09%) in the post-test. We identified a female prevalence, aged between 31 and 45 years, who worked in their unit and had more than five years of professional training. The scores obtained after the educational intervention (post-test) was statistically significant (p<0.0001), in comparison to the pre-test. The educational intervention positively collaborated with the theoretical knowledge of nursing professionals about cardiorespiratory arrest.
Reservoir Simulation Well Data Exchange towards Digital Transformation and Live Earth Models

Automatic updates of simulation models with historical field performance and events is a challenging and time-consuming task that reservoir engineers need to tackle; whether it is to maintain history matched reservoir models (evergreen assets), undertake new calibration exercise or update forecasting studies. The challenge takes another dimension with increasing complexity of field operations (production/injection/drilling/workover), and well designs and configuration of downhole equipment. This paper presents an efficient workflow capitalizing on IR4.0 Digital Twin principles to automate the process of seamlessly integrating and updating historical wells’ information in reservoir simulation models. The objective of this workflow is to drive reservoir simulation towards capitalizing on digital transformation and the Live Earth models concept to revolutionize model calibration and history matching for superior quality of prediction with great confidence. Well data digitization in this workflow was achieved through automating well data acquisition, well data quality checking enforcement and well modeling in interconnected simulation applications. The workflow minimizes human manual interaction with data giving engineers the chance to focus more on reservoir engineering aspects of reservoir engineering tasks. The workflow consists of four steps. The first step is data acquisition in which various types of well data are fetched. The second step is data quality check in which data from different data sources is subjected to engineering and scientific measures (i.e. Quality Indices) that translate engineering knowledge and experience to detect possible data inconsistencies. The third and fourth steps cover exporting and importing relevant data within the reservoir simulation applications’ portfolio where various data types are handled and managed seamlessly. Data and event acquisition workflows were automated to provide seamless well data transfer between different data sources and reservoir simulation pre and post-processing applications. The different types of well data were obtained through automatic fetching from data repository (databases, petrophysical models … etc.). The Quality Check (QC) procedures were automatically performed against deviation surveys, perforations, casing/tubing, flowmeter, cores, formation tops and productivity/injectivity index. This helped in identifying data discrepancy, if any, including missing data entries and contradicting well events. The automation of these workflows significantly reduced the time needed for well data transmission/update to the reservoir models, eliminated human errors associated with data entry or corrections, and helped keeping the models up-to-date (evergreen). Incorporating the digital twin concepts enabled advanced automatic digitization of well information. It provided a data exchange solution that meets E&P requirements and provided more effective and efficient methods of connecting diverse applications and data repositories.
Passive and active sampling of occupational exposures to nitrous oxide among Indian health service dental employees and possible mitigating factors

Nitrous oxide is a commonly used gas in dental facilities and considered safe for patients undergoing dental procedures. However, epidemiological studies show that there are adverse health effects associated with chronic occupational exposure to nitrous oxide, including reproductive issues, neurologic, renal and liver disease. Indian Health Service reports have documented high levels of nitrous oxide during dental procedures. This study compared sampling using the Thermo Scientific TM Miran SapphIRe portable analyzer with the Advanced Chemical Sensor™ Passive Badge, and characterized dental personnel’s exposure to nitrous oxide levels in the breathing zones during dental procedures. Similar exposure groups were determined by job title (Dentist and Dental Assistant) and an ANOVA was used to explore the appropriateness of considering similarity of the groups across 6 dental clinics within the Indian Health Service. An independent t - test was used to determine if there was a mean difference of exposure between the similar exposed groups. A paired t -test was used to compare the similarity of the two sampling methods, and the Bland-Altman analysis was used to assess level of agreement between the two methods. Finally, this study looked at the effect of nitrous