Miracle-dz/UniFAR-FTUs huggingface dataset:
The Caveolin genes: from cell biology to medicine

Caveolae are vesicular organelles (50—100‐nm in diameter) that are particularly abundant in cells of the cardiovascular system, including endothelial cells, smooth muscle cells, macrophages, cardiac myocytes and fibroblasts. In these cell types, caveolae function both in protein trafficking and signal transduction, as well as in cholesterol homeostasis. Caveolins are the structural proteins that are both necessary and sufficient for the formation of caveolae membrane domains. Caveolins 1 and 2 are co‐expressed in most cell types, while the expression of caveolin‐3 is muscle‐specific. Thus, endothelial cells and fibroblasts are rich in caveolins 1 and 2, while cardiac myocytes and skeletal muscle fibers express caveolin‐3. In contrast, smooth muscle cells express all three caveolins (Cav‐1, ‐2, and ‐3). Mechanistically, caveolins interact with a variety of downstream signaling molecules, including Src‐family tyrosine kinases, p42/44 mitogen activated protein (MAP) kinase, and endothelial nitric oxide synthase (eNOS), and hold these signal transducers in the inactive conformation until activation by an appropriate stimulus. In many ways, caveolins serve both to compartmentalize and regulate signaling. Recent studies using caveolin‐deficient mouse models dramatically show that caveolae and caveolins play a prominent role in various human patho‐biological conditions, especially those related to the cardiovascular system. These disease phenotypes include: atherosclerosis, cardiac hypertrophy, cardiomyopathy, pulmonary hypertension, and neointimal hyperplasia (smooth muscle cell proliferation). In addition, caveolins play a significant role in other disease phenotypes, such as cancer, diabetes, bladder dysfunction, and muscular dystrophy, as we discuss in this review. Thus, caveolin‐deficient mice will serve as important new animal models to dissect the intricate role of caveolae and caveolins in the pathogenesis of human diseases.
Ethnobotany of chia,Salvia hispanica L. (Lamiaceae)

Salvia hispanica L, was an important staple Mesoamerican food and medicinal plant in pre-Columbian times. Unlike other Mesoamerican pseudocereal crops such asAmaranthus andChenopodium, it has received comparatively little research attention. An ethnobotanical review of this Mesoamerican crop plantSalvia hispanica has been undertaken to examine changes in use accompanying Spanish colonization. A comparative analysis of accounts of use from the 16th century codices of Mexico and subsequent publications has revealed subtle changes in medicinal, culinary, artistic, and religious uses. Several hypotheses surrounding changes in use through time and the original use(s) that led to domestication are developed and tested through collection of ethnobotanical data in the highlands of western Mexico and Guatemala. A general decline in ethnobotanical knowledge associated with wild populations coupled with a loss of habitat in some locations has degraded important germplasm and knowledge resources for a species with great economic potential. RésuméEn contraste con otras cultivos de pseudocereales de Mesoamérica, comoAmaranthus y Chenopodium, pocas investigaciones se han realizado sobre Salvia hispanica L, a pesar de la importancia que tuvo esta especie como una planta comestible y medicinal en el periodo PreColombino. Se realizó una revision etnobotânica de la especie mesoamericanaSalvia hispanica para analizar los cambios en uso que acompañaron a la colonizaciõn española. Se presentan tablas con las descripciones de usos de códices del sigh XVI y publicaciones subsecuentes que muestran cambios sutiles en los usos médicinales, culinarios, artísticos, y religiosos. Se propusieron varias hipótesis relativas a los cambios en su uso a través del tiempo y su uso original; estas hipótesis se probaron con una colecciôn de datos etnobotánicos obtenidos en las montanas del oeste de México y Guatemala. La pérdida progresiva del conocimiento etnobotánico de las poblaciones silvestres, asociada con la pérdida del habitat en algunos sitios, ha provocado una degradación tanto de importantes recursos genéticos como del conocimiento de una especie con un gran potencial económico.
Peer and maternal influences on the expression of foot-clasp mounting by juvenile male rhesus monkeys.

The display of adultlike foot-clasp mounts by male rhesus monkeys occurs during the 1st year of life in animals reared with their mothers in social groups where peer interaction is possible 24 hr per day. In contrast, this form of mount is rarely displayed if infants are separated from their mothers at 3 months of age and allowed daily . 5-hr periods for peer interaction. To distinguish between maternal and peer access-time influences upon the development of this response, we housed rhesus monkeys with their mothers and allowed either . 5-hr or 24-hr daily access to peers in the presence of their mothers during the 1st year of life. Male infants restricted to . 5-hr periods with peers rarely or never foot-clasp-mounted peers, although 3 of 6 males foot-clasp-mounted their mothers. In contrast, males given 24-hr access to peers regularly mounted peers using the foot-clasp mount. Males from the 2 groups did not differ in total frequencies of all mount types displayed, only in the display of foot-clasp mounts. After maternal separation at the end of the 1st year, rearing effects on the display of mounting persisted into the 2nd year. Males that received 24-hr daily peer access during the 1st year continued to foot-clasp-mount peers whereas . 5-hr males failed to do so, indicating that the experience of mounting one's mother with the adult posture was not sufficient to support peer-oriented foot-clasp mounting at a later age. In addition to deficits in peer-oriented foot-clasp mounting. 5-hr infants displayed higher frequencies of threat and withdrawal behaviors to peers and presented to peers less frequently than did infants from the 24-hr rearing condition. These results contradict a motor deficiency hypothesis to account for the rare display of foot-clasp mounts to peers by males receiving . 5-hr daily access to peers during the 1st year of life. Instead, data support the view that . 5-hr animals either failed to develop positive response patterns necessary for the execution of the foot-clasp mount, or learned negative patterns of social interaction that prevented the display of this cooperative behavior.
Fine-Tuning Private Equity Replication Using Textual Analysis

In this article, the authors use textual analysis to create an investable, dynamic portfolio to mimic the factor characteristics of private equity. First, using textual analysis, they identify firms taken private by those firms in the 10-year period ending June 2018. Second, they use a multifactor model to measure the cross-sectional factor exposures of firms immediately prior to the announcement that they were being acquired by a private equity firm. Finally, they use holdings-based optimization to build a liquid, investible, long-only portfolio that dynamically mimics the factor characteristics of the portfolio of stocks that were taken private. Practitioner applications include interim beta solutions for investors (including venture capital and private equity firms) seeking to deploy excess cash, mitigate underfunding risk, and manage capital calls.
Serological identification of adult T‐cell leukaemia‐associated antigens

Adult T‐cell leukaemia (ATL) is a peripheral T‐cell neoplasm caused by human T‐cell leukaemia virus type I (HTLV‐I). Several clinical observations suggest that some tumour‐associated antigens in ATL may be recognised by the immune system. In this study, we performed the serological screening of an expression library to identify ATL‐associated antigens by using materials from a unique ATL patient with long‐term stable disease. Among five distinct genes isolated, serine/arginine protein kinase 1 (SRPK1), which has been reported to have a restricted normal tissue distribution, was found to be overexpressed in most acute type ATL samples, but not in chronic type ATL or in normal peripheral blood mononuclear cells by real‐time reverse transcription polymerase chain reaction. Interestingly, the overexpression of SRPK1 in aggressive types of ATL was more exclusively observed at the protein level than at the mRNA level. Autologous antibody to SRPK1 was confirmed in the ATL patient using Western blot analysis with plasma, but not detected in asymptomatic HTLV‐I carriers or in healthy volunteers. These results indicate that SRPK1 may be useful for the development of therapeutic and diagnostic methods for patients with ATL.
The Effect of Costimulatory and Interleukin 2 Receptor Blockade on Regulatory T Cells in Renal Transplantation

Regulatory T cells (Treg) are critical regulators of immune tolerance. Both IL‐2 and CD28‐CD80/CD86 signaling are critical for CD4+CD25+FOXP3+ Treg survival in mice. Yet, both belatacept (a second‐generation CTLA‐4Ig) and basiliximab (an anti‐CD25 monoclonal antibody) are among the arsenal of current immunotherapies being used in kidney transplant patients. In this study, we explored the direct effect of basiliximab and belatacept on the Tregs in peripheral blood both in the short term and long term and in kidney biopsies of patients with acute rejection. We report that the combined belatacept/basiliximab therapy has no long‐term effect on circulating Tregs when compared to a calcineurin inhibitor (CNI)‐treated group. Moreover, belatacept‐treated patients had a significantly greater number of FOXP3+ T cells in graft biopsies during acute rejection as compared to CNI‐treated patients. Finally, it appears that the basiliximab caused a transient loss of both FOXP3+ and FOXP3− CD25+ T cells in the circulation in both treatment groups raising important questions about the use of this therapy in tolerance promoting therapeutic protocols.
Corporate Social Responsibility in Practice: The Case of Textile, Knitting and Garment Industries in Malaysia

Malaysia is becoming an increasingly captivating market for international textile retailers. Implementation of Corporate Social Responsibility in textile and apparel industries in Malaysia is necessary because the industry has diversified itself to value-chain, from an original equipment manufacturer (OEM) producer to own brand and design supplier. There are not many studies found on approaches to implementation, drivers, and barriers for Corporate Social Responsibility in the textile sector. The objective of this paper is to examine and analyze approaches, initiatives, adoption, drivers and barriers to CSR implementation in textile and apparel industries in Malaysia. Through this study, the paper aims to understand the perspectives of the CSR practice in Malaysia and advance potential areas that could assist textile and apparel firm management to understand the hurdles preventing CSR implementation. The results of the study indicate that CSR practices among the textile, knitting and garment industry are mostly based on the stakeholders’ model widely seen in the Western world. This study further reports the potential challenges of CSR practices in these industries.
Modulation des cellules dendritiques et macrophages : implications dans le cancer et l'athérosclérose

Au cours de ma these, j’ai etudie la fonction cytotoxique des cellules dendritiques (DC) de patients cancereux comparee a celle de sujets sains. Nous avons montre que les DC generees a partir des monocytes du sang peripherique peuvent acquerir des capacites cytotoxiques importantes apres activation par des faibles doses de LPS. Le potentiel cytotoxique des DC generees a partir de patients cancereux est comparable a celui de sujets sains. Nous avons identifie le mecanisme de cytotoxicite qui fait intervenir la production de peroxynitrite. Apres avoir tue les cellules tumorales, les DC phagocytent des fragments tumoraux, surexpriment des molecules de costimulation et induisent la proliferation des lymphocytes. Un deuxieme axe de recherche au cours de ma these a consiste en l’etude des macrophages inflammatoires et de leur implication dans l’atherosclerose. Les macrophages secretent la CETP (cholesteryl ester transfert protein), proteine-cible des recepteurs LXR (liver X receptor). Nous avons montre que l’expression de la CETP, en reponse aux agonistes LXR, n’est pas augmentee dans les macrophages inflammatoires. Ceci suggere que les macrophages inflammatoires ne participeraient pas a l’augmentation du pool plasmatique de CETP en cas de traitement par des agonistes LXR.
KEPATUHAN PAJAK UMKM DI KABUPATEN KUDUS

This study aims to examine how the influence of demographic factors, taxation system, tax avoidance factors, economic conditions, and the level of trust on MSMEs tax compliance in Kudus District. The tax compliance tested is formal tax compliance and material tax compliance. Sampling technique used in this study is purposive sampling with the number of respondents as much as 79. Methods of data collection using a questionnaire survey and using multiple regression analysis in analyzing data. The results of this study indicate that partially demography factor, taxation system, tax avoidance factor, economic condition, and level of trust have no effect on formal tax compliance, while demography factor and tax system have positive effect on material tax compliance.
Method for optimizing topography-guided ablation of highly aberrated eyes with the ALLEGRETTO WAVE excimer laser.

PURPOSE To evaluate the clinical outcomes of custom topographic neutralizing technique in treating highly aberrated eyes using the WaveLight ALLEGRETTO WAVE Excimer Laser. METHODS A retrospective consecutive case series of 67 eyes with decentered ablations and 48 eyes with symptomatic small optical zones after previous LASIK underwent topography-guided retreatment with the ALLEGRETTO WAVE. Sixteen keratoconus eyes underwent topographic neutralizing technique photorefractive keratectomy (PRK). The study assessed preoperative and 6-month and 1-year postoperative results regarding best spectacle-corrected visual acuity (BSCVA), uncorrected visual acuity (UCVA), topography, and predictability. RESULTS Sixty-seven eyes with previously decentered optical zones had an improvement of centration from 0.92 mm preoperatively to 0.30 mm postoperatively relative to pupil center (P<.01). Twenty-nine percent of these eyes gained 1 or more lines of BSCVA, whereas 71% had no change in BSCVA. Forty-eight eyes with previously small optical zones had an increase of the central monodioptric optical zone from 3.9 mm to 5.6 mm (P<.01). Nineteen percent of eyes had an improvement of at least 1 line, whereas 75% had no change in BSCVA and 6% lost 1 line. Sixteen keratoconus eyes had custom topographic neutralizing technique PRK as an alternative to penetrating keratoplasty. All eyes had improvement of astigmatism up to 5.00 diopters (D), with a mean change of 1.68+/-1.62 D. Best spectacle-corrected visual acuity was unchanged in 8 (50%) eyes, with 4 (25%) eyes gaining 1 line, 2 (12%) eyes gaining 2 lines, and 2 (12%) eyes losing 1 line of BSCVA at 6 months. CONCLUSIONS Management of some highly aberrated eyes is now possible with topography-guided ablation using the WaveLight ALLEGRETTO platform and custom topographic neutralizing technique. Safety was acceptable for small optical zone and decentered ablation retreatments. The topography-guided ablation could be an alternative treatment for keratoconus patients if keratoplasty is otherwise indicated. The algorithms for custom topographic neutralizing technique need further refinement.
The Impact of Corporate Governance on Customer Satisfaction and Loyalty of Islamic Insurance Company in Indonesia

The implementation of the corporate governance in managing Islamic insurance companies hopefully can support the performance of companies to provide the best services for consumers in accordance with the Islamic principles. Good performance related to transparancy, independency, accountability, responsibility, fairness and sharia compliance are expected to increase the trust of potential customers of Islamic insurance. This study aims to examine the impact of the corporate governance toward customer satisfaction and customer loyalty in Islamic insurance companies in Indonesia. A purposive sampling technique is used for this research. Using primary data through questionnaires to Islamic insurance customer, the research finds that corporate governance positively influence the customer satisfaction and customer loyalty. Another result reveals that the customer satisfaction positively influences customer loyalty. This study recommends the strengthening of corporate governance implementation to enhance the attractiveness of Islamic insurance company and give impact on customer satisfaction and customer loyalty.
Food groups and risk of squamous cell esophageal cancer in Northern Italy

To better understand the nutritional etiology of squamous cell esophageal cancer, we conducted a case‐control study in 3 areas of northern Italy. A total of 304 incident, histologically confirmed cases of squamous cell carcinoma of the esophagus (275 men, 29 women) and 743 hospital controls (593 men, 150 women) with acute, non‐neoplastic conditions, not related to smoking, alcohol consumption or long‐term diet modification, were interviewed during 1992 to 1997. The validated food‐frequency questionnaire included 78 questions on food items or recipes, which were then categorized into 19 main food groups, and 10 questions on fat intake pattern. After allowance for age, sex, education, area of residence, tobacco smoking, alcohol drinking and non‐alcohol energy, a significant increased risk emerged for high consumption of soups (OR=2.1 for the highest vs. lowest quintile), whereas inverse associations with esophageal cancer risk were observed for pasta and rice (OR=0.7), poultry (OR=0.4), raw vegetables (OR=0.3), citrus fruit (OR=0.4) and other fruit (OR=0.5). The associations with dietary habits were consistent in different strata of tobacco smoking and alcohol drinking. Among added lipids, olive oil intake showed a significant reduction of esophageal cancer risk, even after allowance for total vegetable consumption (OR=0.4), while butter consumption was directly associated with this risk (OR=2.2). Our results thus provide further support to the evidence that raw vegetables and citrus fruit are inversely related to the risk of squamous cell esophageal cancer and suggest that olive oil may also reduce this risk. Int. J. Cancer 87:289–294, 2000. © 2000 Wiley‐Liss, Inc.
Outlining a Process to Manage the Complexity of Enterprise Systems Integration

New service combinations are constantly needed to be created from the array of information systems and technologies, developed in different times for different purposes, crossing the organizational boundaries. Integration is the key matter in organizations, yet it is also an ambiguous and often a misunderstood concept in the field of information systems. In this paper, we construct an integration process from an inductive study in a large manufacturing enterprise, by examining its long-term ERP development endeavour. The process consists of four sub-processes with dedicated actors and activities. Integration Governance is needed to align Integration Realization with the strategic goals of the organization. Integration Housekeeping is dedicated to standardization activities and keeping the architectural description of the enterprise systems’ landscape updated, and to aid Realization. By utilizing the assets produced by Governance and Housekeeping Integration Evaluation is done to decide whether it is feasible to set up an integration project or abandon the initiative. The process helps managers to manage the complexity of enterprise systems integration and avoid its pitfalls.
Controversies and challenges in the current management of nasopharyngeal cancer

Nasopharyngeal carcinoma is uncommon worldwide, but poses a significant public health burden in endemic regions. Primary treatment for nonmetastatic disease is by radiation therapy, which has evolved from simple 2D-planning techniques to intensity-modulated radiation therapy. The role of systemic therapy has also become more prominent, with concurrent cisplatin-based chemoradiation the current standard of care for locally advanced disease based on multiple Phase III studies. Based on these advances, the prognosis of nasopharyngeal carcinoma appears to have improved significantly over the past two decades. Nevertheless, there are areas of substantial uncertainty and divergent views in the optimal treatment strategy. Distant metastases have become the dominant mode of treatment failure with the excellent local control provided by intensity-modulated radiation therapy. Recent studies have focused on this challenge of treating micrometastases while keeping toxicities manageable. Radiation therapy techniques continue to be refined to maintain consistently high locoregional tumor control while decreasing the probability of acute and late toxicities. This article discusses some of the current issues confronting the multidisciplinary team managing this disease.
Otelixizumab: a novel agent for the prevention of type 1 diabetes mellitus

Introduction: Type 1 diabetes mellitus is a chronic, progressive autoimmune disorder linked to numerous genetic and environmental factors. Insulin is the only treatment and preventative strategies do not currently exist. An obvious need exists to develop a safe regimen that suppresses the progression of the disease. Areas covered: A MEDLINE search (1966–June 2011) was conducted for English-language articles using the terms ‘otelixizumab’, ‘anti-CD3 antibody’ and ‘prevention of type 1 diabetes mellitus’. Relevant literature on otelixizumab, an anti-CD3 monoclonal antibody, currently in Phase III clinical trials for prevention of T1DM is discussed. Expert opinion: Studies suggest that a monoclonal antibody directed against CD3 mitigates the deterioration in insulin production and decreases the rise in insulin requirement in recent onset T1DM for up to five years. The benefit was most pronounced in younger patients and in those with higher initial β-cell function. Adverse effects were significant but transient. Otelixizumab shows great promise but leaves room for improvement. Results of ongoing trials will help define its role in the prevention of T1DM.
INOVAÇÕES EM PROCESSOS COMO FORMA DE ESTRUTURAR CADEIAS DE SUPRIMENTOS SUSTENTÁVEIS

Este estudo tem como objetivo discutir a possibilidade de estruturar uma cadeia de suprimentos, atraves de inovacoes em processos e investigar que ferramentas de gestao da cadeia de suprimentos poderiam orientar a cadeia em vista da sustentabilidade. A prevalecer o modelo de producao e consumo atual, que se caracteriza por romper constantemente o equilibrio dinâmico da bioesfera, o planeta e insustentavel a longo prazo, talvez ja no medio prazo. Desta forma, as atividades produtivas necessitam, urgentemente, considerar os impactos ambientais que geram. Neste sentido, as inovacoes em processos tem um papel estrategico nas organizacoes como fonte poderosa de vantagens competitivas, seja pela capacidade de desenvolver algo que os concorrentes nao conseguem ou de faze-lo de forma excelente (TIDD; BESSANT; PAVITT, 2001). Nesta perspectiva, diversos estudos mostram uma inter-relacao positiva entre a performance organizacional e atividades ligadas a praticas ambientalmente corretas nas atividades de suprimento(ZHU & SARKIS, 2004; RAO, 2002). O estudo, atraves da discussao desenvolvida, aponta para um ponto convergente no que tange a sustentabilidade: a necessidade de se adotar novos processos produtivos, que sejam menos poluentes e que nao degradem o meio ambiente. Assim, a complexidade que envolve os processos decisorios das organizacoes, suas relacoes com os diversos elos em suas cadeias de suprimento e outros atores, demanda novas formas de orientar as decisoes. Estas nao podem ser excludentes, isto e, opta-se por uma ou por outra, mas necessitam permitir a convivencia simultânea dos interesses da sociedade, respeitar o meio ambiente e prover os resultados necessarios a sobrevivencia e crescimento das empresas.