Miracle-dz/UniFAR-FTUs huggingface dataset:
Local Pattern Detection

Introduction The dramatic increase in available computer storage capacity over the last 10 years has led to the creation of very large databases of scienti? c and commercial information. The need to analyze these masses of data has led to the evolution of the new ? eld knowledge discovery in databases (KDD) at the intersection of machine learning, statistics and database technology. Being interdisciplinary by nature, the ? eld o? ers the opportunity to combine the expertise of di? erent ? elds intoacommonobjective.Moreover,withineach? elddiversemethodshave been developed and justi? ed with respect to di? erent quality criteria. We have toinvestigatehowthesemethods cancontributeto solvingthe problemofKDD. Traditionally, KDD was seeking to ? nd global models for the data that - plain most of the instances of the database and describe the general structure of the data. Examples are statistical time series models, cluster models, logic programs with high coverageor classi? cation models like decision trees or linear decision functions. In practice, though, the use of these models often is very l- ited, because global models tend to ? nd only the obvious patterns in the data, 1 which domain experts already are aware of . What is really of interest to the users are the local patterns that deviate from the already-known background knowledge. David Hand, who organized a workshop in 2002, proposed the new ? eld of local patterns.
Different analysis strategies of 16S rRNA gene data from rodent studies generate contrasting views of gut bacterial communities associated with diet, health and obesity

Background One of the main functions of diet is to nurture the gut microbiota and this relationship affects the health of the host. However, different analysis strategies can generate different views on the relative abundance of each microbial taxon, which can affect our conclusions about the significance of diet to gut health in lean and obese subjects. Here we explored the impact of using different analysis strategies to study the gut microbiota in a context of diet, health and obesity. Methods Over 15 million 16S rRNA gene sequences from published studies involving dietary interventions in obese laboratory rodents were analyzed. Three strategies were used to assign the 16S sequences to Operational Taxonomic Units (OTUs) based on the GreenGenes reference OTU sequence files clustered at 97% and 99% similarity. Results Different strategies to select OTUs influenced the relative abundance of all bacterial taxa, but the magnitude of this phenomenon showed a strong study effect. Different taxa showed up to 20% difference in relative abundance within the same study, depending on the analysis strategy. Very few OTUs were shared among the samples. ANOSIM test on unweighted UniFrac distances showed that study, sequencing technique, animal model, and dietary treatment (in that order) were the most important factors explaining the differences in bacterial communities. Except for obesity status, the contribution of diet and other factors to explain the variability in bacterial communities was lower when using weighted UniFrac distances. Predicted functional profile and high-level phenotypes of the microbiota showed that each study was associated with unique features and patterns. Conclusions The results confirm previous findings showing a strong study effect on gut microbial composition and raise concerns about the impact of analysis strategies on the membership and composition of the gut microbiota. This study may be helpful to guide future research aiming to investigate the relationship between diet, health, and the gut microbiota.
Syphilis and HIV infection in patients with hepatitis A: a preliminary study from one centre in Poland

Address for correspondence: Maciej Bura MD, PhD, Department of Infectious Diseases, Hepatology and Acquired Immunodeficiencies, Poznan University of Medical Sciences, 3 Szwajcarska St, 61-285 Poznan, Poland, phone: +48 61 873 93 76, fax: +48 61 877 36 87, e-mail: mbura@umed.poznan. pl Received: 24.01. 2019, accepted: 10.05. 2019. Syphilis and HIV infection in patients with hepatitis A: a preliminary study from one centre in Poland
Effect of Urinary Incontinence on the Quality of Life of Older Adults in Riyadh: Medical and Sociocultural Perspectives

Objectives The objective of the study is to determine the impact of urinary incontinence (UI) on the quality of life (QoL) of the Saudi elderly population. Besides, we investigated individuals’ help-seeking behaviors and the religious and cultural aspects of UI among the Saudi elderly. Methods We conducted a cross-sectional study using a random sample of 150 Saudi older adults of both genders. The participants were outpatient clinics of government and private hospitals in Riyadh from January-March 2019. Volunteer medical students interviewed and distributed a standard questionnaire form (Arabic version of the ICIQ-SF [International Consultation on Incontinence Questionnaire] with 33 additional questions, four of which came from them from the King's Health Questionnaire (KHQ) to the targeted population. Results In this study, there were 124 elderly participants (response rate 83%), of whom 62.9% were women. The mean age was 71.9 (±7.8). The "moderate" and "severe" ICIQ scores account for 78 (62.9%) and 32 (25.8%), respectively. There was a significant association between the ICIQ scores severity of UI and increasing BMI, nocturnal diuresis, urinary tract infection, and lung diseases. However, 36.3% of participants did not seek help due to misconceptions about UI and aging, unavailability of treatment, and embarrassment of sharing such symptoms with others. The participants suffered from limitations of social life (36.3%), a negative impact on their physical activity (18.5%), personal hygiene (21.8%), and their self-esteem (32.3%). About 17% and 33.1% of participants repeat ablution and prayers of participants, respectively. Conclusions Urinary incontinence (UI) is a common and distressing problem in the elderly. A large proportion of the participants had a detrimental effect on their quality of life. A substantial percentage of older adults did not seek help. As a result, we recommended raising awareness about UI, QoL, the misconceptions, and encourage them to overcome the stigma of embarrassment and seek medical help.
Definition and review on a category of long non-coding RNA: Atherosclerosis-associated circulating lncRNA (ASCLncRNA)

Atherosclerosis (AS) is one of the most common cardiovascular system diseases which seriously affects public health in modern society. Finding potential biomarkers in the complicated pathological progression of AS is of great significance for the prevention and treatment of AS. Studies have shown that long noncoding RNAs (lncRNAs) can be widely involved in the regulation of many physiological processes, and have important roles in different stages of AS formation. LncRNAs can be secreted into the circulatory system through exosomes, microvesicles, and apoptotic bodies. Recently, increasing studies have been focused on the relationships between circulating lncRNAs and AS development. The lncRNAs in circulating blood are expected to be new non-invasive diagnostic markers for monitoring the progression of AS. We briefly reviewed the previously reported lncRNA transcripts which related to AS development and detectable in circulating blood, including ANRIL, SENCR, CoroMarker, LIPCAR, HIF1α-AS1, LncRNA H19, APPAT, KCNQ1OT1, LncPPARδ, LincRNA-p21, MALAT1, MIAT, and UCA1. Further researches and a definition of atherosclerosis-associated circulating lncRNA (ASCLncRNA) were also discussed.
Transport des protons dans l'ionosphère aurorale

Les electrons et les protons suprathermiques, issus du soleil et precipitant dans l'atmosphere des hautes latitudes, constituent une source d'energie de l'ionosphere terrestre. Ces particules interagissent avec le gaz thermique ambiant par collisions. L'equation de Boltzmann, fournissant les flux de particules en altitude, energie et angle d'attaque, permet une description des plus completes du transport de ces particules. Nous la redemontrons dans le cas dissipatif, le plus general, et nous proposons une resolution originale des equations de transport des protons et des atomes d 'hydrogene, equations couplees via les reactions de changement de charge. Cette resolution, fondee sur l'introduction de forces dissipatives pour decrire la degradation energetique des particules precipitant, permet la prise en compte des redistributions angulaires, d'origine collisionnelle ou magnetique, jusqu'alors negligees. Pourtant, leur effet a ete observe, depuis le sol, sur les emissions des atomes d 'hydrogene, comme en temoigne la composante, decalee vers le rouge, du profil Doppler selon le zenith magnetique. La resolution adoptee ici est validee par comparaison avec un autre modele, dans le cas classique sans redistribution angulaire. L'influence de l'effet de miroir magnetique est discutee: cet effet ne semble pas pouvoir expliquer, a lui seul, le decalage vers le rouge observe. La redistribution angulaire collisionnelle doit jouer un role significatif. Enfin, une comparaison de notre modele avec les donnees de la fusee Proton 1 est proposee.
Stabilizing Queuing Networks With Model Data-Independent Control

Classical queuing network control strategies typically rely on accurate knowledge of model data, i.e., arrival and service rates. However, such data are not always available and may be time-variant. To address this challenge, we consider a class of model data-independent (MDI) control policies that only rely on traffic state observation and network topology. In this article, we focus on the MDI control policies that can stabilize multiclass Markovian queuing networks under centralized and decentralized policies. Control actions include routing, sequencing, and holding. By expanding the routes and constructing piecewise-linear test functions, we derive an easy-to-use criterion to check the stability of a multiclass network under a given MDI policy. For stabilizable multiclass networks, we show that a centralized, stabilizing MDI policy exists. For stabilizable single-class networks, we further show that a decentralized, stabilizing MDI policy exists. In addition, for both settings, we construct explicit policies that attain maximal throughput and present numerical examples to illustrate the results.
Allen reference atlas : a digital color brain atlas of the C57Black/6J male mouse

". this atlas acts not only as a key companion to the Allen Reference Atlas but also as a harbinger of things to come. " -Genes, Brain and Behavior, 2010 The best resource available for brain research! The Allen Reference Atlas is available for the first time in this lavishly produced, full-color print edition. This exciting new resource provides users with a meticulously selected and compiled collection of key information from the highly successful web-based Allen Brain Atlas, the now-famous online mouse brain anatomical atlas and gene expression database (www.brain-map.org). Including both coronal and sagittal mouse brain sectional views, these finely detailed brain map images have been carefully chosen for maximum utility and information content, and are presented as full-color plates on pages with corresponding text labels and lists of selected genetic markers. Every brain structure annotated in the Atlas is assigned a distinct color based on its hierarchical position in the brain, which not only provides stunning visual effects to emphasize brain organization, but also facilitates unique definition and segmentation, which is critical to informatics processing and computer-generated 3D reconstruction in the online Allen Brain Atlas. In addition, more than eighty genes showing unique expression patterns in the brain were carefully selected and are presented with the brain map images as molecular markers, for substantially increasing the accuracy of brain structure delineations. The brain map images are the heart and soul of the Allen Reference Atlas, but also included are extremely useful text materials such as thoughtfully annotated nomenclature tables, comprehensive indices, lists of abbreviations, and a thorough and up-to-date bibliography. A free accompanying CD-ROM contains all of the Atlas images in a black-and-white format, perfect for quick reference and use in presentations. The Allen Reference Atlas is a valuable addition to the reference libraries of millions of neuro-scientists, molecular biologists, genomicists, genomics researchers, informaticians, informatics researchers, and many other scientists for whom beautifully developed and perfectly accurate brain reference images are an indispensable tool. The Allen Institute for Brain Science is an independent, 501(c)(3) non-profit medical research organization dedicated to performing innovative basic research on the brain and distributing its discoveries to researchers around the world. Through its efforts, the Institute aims to advance understanding of the brain in health and disease and have a positive, long-lasting impact on brain science. The Institute was established by philanthropist Paul G. Allen and Jody Allen Patton. Available in print format (with CD-ROM), as DVD edition, and as comprehensive reference set.
Clinical manifestations of diffuse large B-cell lymphoma in the skin and subcutaneous tissue a case series study

Address for correspondence: Assoc. Prof. Grażyna Kamińska-Winciorek MD, PhD, Department of Bone Marrow Transplantation and Oncohematology, Maria Skłodowska-Curie National Research Institute of Oncology (MSCNRIO), Gliwice Branch, 15 Wybrzeże Armii Krajowej St, 44-101 Gliwice, Poland, phone: +48 32 278 8523, fax: +48 32 278 91 49, +48 604 070 208, e-mail: grazyna.kaminskawinciorek@gmail.com Received: 20.03. 2020, accepted: 6.04. 2020. Clinical manifestations of diffuse large B‐cell lymphoma in the skin and subcutaneous tissue a case series study
Etude cristallographique des protéines NikA et NikR impliquées dans la transport du nickel chez Escherichia coli. Quant la structure de NikA met en évidence l'existence possible d'un nouveau métallophore.

Le nickel est un cofacteur essentiel a l'activite de certaines proteines bacteriennes, mais il est egalement toxique a forte concentration. De ce fait, il est indispensable aux bacteries de posseder un systeme d'import du Ni2+ specifique et hautement regule. Dans le cas d'Escherichia coli, il s'agit d'un systeme ABC compose des cinq proteines de l'operon nikabcde : NikA, une proteine periplasmique, NikB et NikC, deux proteines formant un pore a travers la membrane interne, et les proteines NikD et NikE, deux proteines cytoplasmiques hydrolysant l'ATP. La regulation de l'expression de cet operon est assuree par FNR, l'activateur, et de NikR, le represseur. Dans un premier temps, nous avons travaille sur une structure de la proteine NikA, resolue a partir de cristaux appartenant au systeme orthorhombique. Elle nous a permis de montrer que NikA ne fixait pas le nickel sous une forme pentahydratee comme cela etait decrit dans la litterature, mais sous la forme d'un complexe FeEDTA(H2O)-, ce qui suggere que le nickel ne se fixe pas directement a la proteine, mais par l'intermediaire d'un metallophore de structure proche de celle de l'EDTA. En remplacant l'etape d'extraction periplasmique a l'EDTA par une etape utilisant le chloroforme, nous avons resolu, une seconde structure de NikA a partir de cristaux appartenant au systeme cristallin hexagonal. Dans ce cas, on observe, dans le site de fixation de la proteine, un nickel en complexe avec une molecule similaire a l'EDTA, laquelle a de fortes chances d'etre le metallophore physiologique, que nous avons tente de caracteriser. Nous abordons aussi des etudes cristallographiques preliminaires concernant NikR.
Electrochemical Performance of SnPO4-coated LiNi1/3Mn1/3Co1/3O2 Cathode Materials

A Sn phosphate was successfully coated to the surface of LiNi1/3Co1/3Mn1/3O2 particles using a new method we developed. The elements Sn and P were observed to be uniformly distributed on the surface of the LiNi1/3Co1/3Mn1/3O2. After the Sn phosphate coating, the onset temperature shifted up to about 250 oC, and the exothermic value also decreased to 116.3 J/g, i.e. the thermal stability of the material was enhanced.The rate capability of the 1 wt% Sn phosphate-coated LiNi1/3Co1/3Mn1/3O2 materials was enhanced at room temperature and 60 oC. However, a 3 wt% Sn phosphate coating degraded the electrochemical performance. The 1 wt% Sn phosphate-coated material showed improved cycle performance compared to that of the bare material at room temperature and 60 oC. It is believed that the oxide coating layer prevented direct contact with the organic electrolyte.
Empirical or susceptibility-guided treatment for Helicobacter pylori infection? A comprehensive review

Although susceptibility-guided therapy is frequently recommended for Helicobacter pylori infection, the evidence available to date supporting this strategy is limited. The aim of the present article is to review the advantages and limitations of the susceptibility-guided and the empirical strategies to treat this infection. We performed a bibliographic search to identify studies investigating H. pylori susceptibility-guided therapy. Culture is not the only way to assess antibiotic resistance, as different polymerase chain reaction-based approaches have been developed as alternative methods. For detecting H. pylori antimicrobial resistance, a molecular approach based on a stool sample might enable more convenient, time-saving methods. Unfortunately, the antimicrobial susceptibility cannot be obtained in all cases. Furthermore, antibiotic susceptibility testing in clinical practice yields useful information only for a few antibiotics: clarithromycin, metronidazole, and quinolones. In addition, susceptibility towards clarithromycin and metronidazole in vitro does not necessarily lead to eradication in vivo. In the case of H. pylori therapy failure, we should not re-administer any of the antibiotics against which H. pylori has probably become resistant. Our updated meta-analysis showed that susceptibility-guided treatment is not better than empirical treatment of H. pylori infection in first-line therapy if the most updated quadruple regimens are empirically prescribed, and similar efficacy results were also demonstrated with the two strategies for second-line therapy. Cumulative H. pylori eradication rate with several successive rescue therapies empirically prescribed reaches almost 100%. Finally, the studies that have evaluated the cost-effectiveness of the susceptibility-guided treatment have achieved contradictory results. In summary, we can conclude that the evidence is too limited to support the generalized use of susceptibility-guided therapy for H. pylori treatment in routine clinical practice, either as first-line or as rescue treatment. Nevertheless, it would be recommended that susceptibility tests are performed routinely, even before prescribing first-line treatment, in specialized centers with an interest in H. pylori management.
Time is brain: timing of revascularization of brain arteries in stroke

Abstract Ischaemic stroke is the second leading cause of mortality and disability in the western world. Revascularization interventions are the cornerstone of the acute treatment of this pathology and must be administered as soon as possible after the patient’s arrival. They consist of intravenous thrombolysis (IVT) with alteplase, recommended by the guidelines within 4.5 h of the onset of symptoms, and endovascular treatment, recommended within 6 h of the onset of symptoms. The individualized patient selection based on the extent of the mismatch between the penumbra and the ischaemic core allowed to overcome the limits imposed by the rigid time windows, defining a benefit of mechanical revascularization therapies up to 24 h from the theoretical onset of symptoms (last time the patient was known to be well) and up to 9 h for IVT since the theoretical onset of symptoms (last time the patient was known to be well). Advanced neuroimaging methods with perfusion studies are a fundamental tool in patient selection. Their spread in the territory, together with a greater availability of neurovascular treatment units are desirable to ensure a fair delivery of treatment to all patients with ischaemic stroke.
Maternal and child health inequalities among migrants: the case of Haiti and the Dominican Republic

ABSTRACT Objective. To assess coverage and inequalities in maternal and child health interventions among Haitians, Haitian migrants in the Dominican Republic and Dominicans. Methods. Cross-sectional study using data from nationally representative surveys carried out in Haiti in 2012 and in the Dominican Republic in 2014. Nine indicators were compared: demand for family planning satisfied with modern methods, antenatal care, delivery care (skilled birth attendance), child vaccination (BCG, measles and DPT3), child case management (oral rehydration salts for diarrhea and careseeking for suspected pneumonia), and the composite coverage index. Wealth was measured through an asset-based index, divided into tertiles, and place of residence (urban or rural) was established according to the country definition. Results. Haitians showed the lowest coverage for demand for family planning satisfied with modern methods (44.2%), antenatal care (65.3%), skilled birth attendance (39.5%) and careseeking for suspected pneumonia (37.9%), and the highest for oral rehydration salts for diarrhea (52.9%), whereas Haitian migrants had the lowest coverage in DPT3 (44.1%) and oral rehydration salts for diarrhea (38%) and the highest in careseeking for suspected pneumonia (80.7%). Dominicans presented the highest coverage for most indicators, except oral rehydration salts for diarrhea and careseeking for suspected pneumonia. The composite coverage index was 79.2% for Dominicans, 69.0% for Haitian migrants, and 52.6% for Haitians. Socioeconomic inequalities generally had pro-rich and pro-urban pattern in all analyzed groups. Conclusion. Haitian migrants presented higher coverage than Haitians, but lower than Dominicans. Both countries should plan actions and policies to increase coverage and address inequalities of maternal health interventions.