Miracle-dz/UniFAR-FTUs huggingface dataset:
Chirality Induced Spin Selectivity - The Role of Electron Correlations.

Chirality induced spin selectivity, discovered about a decade ago in helical molecules, is a non-equilibrium effect that emerges from the interplay between geometrical helicity and spin-orbit interactions. Several model Hamiltonians building on this interplay have been proposed and while these can yield spin-polarized transport properties that agrees with experimental observations, they simultaneously depend on unrealistic values of the spin-orbit interaction parameters. It is likely, however, that a common deficit originates from the fact that all these models are uncorrelated, or, single-electron theories. Therefore, chirality induced spin selectivity is, here, addressed using a many-body approach, which allows for non-equilibrium conditions and a systematic treatment of the correlated state. The intrinsic molecular spin-polarization increases by two orders of magnitudes, or more, compared to the corresponding result in the uncorrelated model. In addition, the electronic structure responds to varying external magnetic conditions which, therefore, enables comparisons of the currents provided for different spin-polarizations in one of the (or both) leads between which the molecule is mounted. Using experimentally feasible parameters and room temperature, the obtained normalized difference between such currents may be as large as 5 -- 10 % for short molecular chains, clearly suggesting the vital importance of including electron correlations when searching for explanations of the phenomenon.
Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Background: Although hydromethylthionine is a potent tau aggregation inhibitor, no difference was found in either of two Phase III trials in mild to moderate Alzheimer’s disease (AD) comparing doses in the range 150–250 mg/day with 8 mg/day intended as a control. Objective: To determine how drug exposure is related to treatment response. Methods: A sensitive plasma assay for the drug was used in a population pharmacokinetic analysis of samples from 1,162 of the 1,686 patients who participated in either of the Phase III trials with available samples and efficacy outcome data. Results: There are steep concentration-response relationships for steady state plasma levels in the range 0.3–0.8 ng/ml at the 8 mg/day dose. Using a threshold based on the lower limit of quantitation of the assay on Day 1, there are highly significant differences in cognitive decline and brain atrophy in patients with above threshold plasma levels, both for monotherapy and add-on therapy, but with effect sizes reduced by half as add-on. Plasma concentrations in the range 4–21 ng/ml produced by the high doses are not associated with any additional benefit. Conclusions: Hydromethylthionine has pharmacological activity on brain structure and function at the 8 mg/day dose as monotherapy or as add-on to symptomatic treatments. This combined with a plateau at higher doses is consistent with the lack of dose-response seen in the Phase III trials. Treatment benefit is predicted to be maximal at 16 mg/day as monotherapy. A placebo-controlled trial in mild/moderate AD is now ongoing to confirm efficacy at this dose.
The Factors Influencing Customer Co- Creation

Introduction: In today's business, organizations are working with external stakeholders to develop a better product. Customers are one such stakeholder with whom organizations collaborate to develop a product fulfilling their needs. This process of Co-Creation facilitates organizations to get closer to their customers. Also in the study made in the year 2016 for the 19th annual global CEO survey, 90% of the CEOs have claimed Customers to be their main priorities. Further in the literature has also debated the process of customer co-creation being complex and studies have been made to understand the Ups and Downs of the process. Problem Background: Based on the opportunity in the field of Co-Creation growing rapidly and literature arguing on both Success and failure of the process, we in our thesis aim to address the gap of identifying the factors that influence the Customer Co-Creation Process. Purpose​: The Purpose of our thesis was to Identify the Factors for Organizations that Influence the process and suggest to imply those factors during the process of Co-Creation for a better result. Methodology​: To answer our research question we chose a qualitative approach by interviewing a total of 5 members from different organizations and different businesses in a semi-structured interview format. We chose to do research from both Customer and Organizational perspective, we formed 2 cases out of the 4 interviews and one as an expert in the field of New Product Development. Findings​: The main findings of our research shows 6 Main Influencing Factors and 12 Sub Factors within 6 main factors that enrich the process of co-creation. The factors are Communication (Feedback & Highlighting the need to Customer), Management (Environment, Relationship Management, Flexibility/Exploratory, Leadership, Rewards/Incentives, Selection of Customer), Transparency, Commitment & Trust (Secrecy Concern, Sharing of IP), Consistency, Training (Employee and Customer). Conclusions: Our research shows the factors on the application during the co-creation process can influence the process to a better output. We have suggested the organizations in our Organizational Implications on how these factors can influence the process to a better output. Thus, answering our research question.
A Proposed Method for Laboratory-Based Evaluation of Personalised Information Retrieval

Comparative evaluation of Information Retrieval Systems (IRSs) using publically available test collections has become an established practice in Information Retrieval (IR). This approach using the popular Cranfield evaluation paradigm enables researchers to compare alternative methods of addressing a specific IR task. This strategy has not to date been applied to the evaluation of Personalised Information Retrieval (PIR), for which evaluation has generally focused on user-based studies. While such studies these experiments provide many valuable insights, they do not enable the systematic comparative evaluation of the combination of IR methods and user models in alternative algorithmic approaches to PIR. In an attempt to enable such comparative invesigations, we introduce an experimental framework for the creation of test collections to facilitate repeatable laboratory-based evaluation of PIR, together with a prototype evaluation tool to analyze results collected using these collections.
miR-760 regulates skeletal muscle proliferation in rheumatoid arthritis by targeting Myo18b

MicroRNAs serve an important role in the development of several diseases. Numerous genes regulate the skeletal muscle differentiation of C2C12 myoblasts. The role of miR-760 in rheumatoid arthritis (RA) has not been reported, to the best of our knowledge. Therefore, the aim of the present study was to examine the role of miR-760 in regulating skeletal muscle proliferation in RA. Potential genes functionally involved in the tarsal joint of a collagen-induced RA model were identified using Gene Expression Omnibus. Reverse transcription-quantitative PCR and western blot analyses were performed to determine the mRNA and protein expression levels. The proliferation, cell cycle progression and migration of C2C12 myoblasts were detected using Cell Counting Kit-8, flow cytometry and wound-healing assays, respectively. TargetScan was used to predict the potential target genes of miR-760, and this was verified using a dual-luciferase reporter assay. In the present study, myosin-18b (Myo18b) expression was determined to be downregulated in the RA model. Silencing Myo18b decreased the proliferation, abrogated the cell cycle progression, and reduced the migration and differentiation of C2C12 myoblasts. Expression levels of cyclin-dependent kinase 2, cyclin D1, matrix metalloproteinase (MMP)-2, MMP-9, myogenin and myosin heavy chain 6 were all decreased when Myo18b was silenced. Furthermore, overexpression of Myo18b induced opposing effects on C2C12 myoblasts. It was shown that Myo18b was a target gene of miRNA-760. Overexpression of miR-760 decreased proliferation, cell cycle progression, migration and differentiation in C2C12 myoblasts, and decreased the expression of Myo18b. The opposite results were observed when miR-760 was downregulated. In conclusion, miR-760 inhibited proliferation and differentiation by targeting Myo18b in C2C12 myoblasts. The results of the present study may contribute to understanding the mechanisms underlying RA skeletal muscle proliferation, and miR-760/Myo18b may serve as potential targets for treating patients with RA.
A Phase II Randomized Study of HIV-Specific T-Cell GeneTherapy in Subjects with Undetectable Plasma Viremiaon Combination Antiretroviral Therapy

1University of California, San Francisco and San Francisco General Hospital, Bldg 80, Ward 84, 995 Potrero Ave., San Francisco, California, 94110, USA2ViRx Inc., 1375 Sutter St., Ste. 407, San Francisco, California 94109, USA 3University of California Los Angeles Center for Health Sciences, MRL 2734, 675 Charles E. Young Dr. S. , Los Angeles, California 90095, USA 4Massachusetts General Hospital, CNY 7214, 13th St., Bldg. 149, Charlestown, Massachusetts 02129, USA 5Advanced Research Associates, 1300 Gilmore St., Mountain View, California 94940, USA 6Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA 7University of California, San Diego, School of Medicine, 9500 Gilman Dr., La Jolla, 92093, and San Diego Veterans Administration Health Care System, California USA 8Roche Molecular Systems, 1145 Atlantic Ave., Alameda, California, 94501, USA 9Abramson Institute, University of Pennsylvania, 421 Curie Blvd., Philadelphia, Pennsylvania 19104, USA 10Cell Genesys, Inc., 342 Lakeside Drive, Foster City, California 94404, USA
Acoustic optimization of curved architecture in practice: the new Straight Cultural Arts Center in Fuzhou

October 2018 saw the inauguration of a new cultural center in Fuzhou, China. The complex consists of 5 buildings, including a 800 seat multipurpose hall, a 1700 seat opera hall and a 1000 seat symphony hall. The design of both the symphony and opera halls was entirely based on curved surfaces, both convex and concave, covered with local ceramic tiles. Providing the right amount, distribution and quality of early reflections thus required a precise analysis of the acoustic behavior of curved surfaces. The acoustic design interacted with the architecture in precisely shaping those curves in 3D. In order to explore the acoustic potential and detect problems related to the architectural concept of both rooms, novel geometrical acoustics analysis algorithms were developed within NURBS modeling software. Optimization of the curved surfaces results from a meeting of minds between the output of these algorithms, the interpretation of the acoustic consultant, and the required integration of acoustic solutions within the global architectural concept and building design. The analysis procedure and geometrical acoustics algorithms used in both rooms will be presented in detail, as well as the related decision-making process, the acoustic predictions and the measurement results of the three built halls.
What is it in Knowledge Management that is not in Information Management?

The internal and external environment is always changing which calls for relevant and appropriate information and knowledge application in organisational development. Information and knowledge are the only resources that do not decrease with use. Knowledge actually increases with use. Information is the resource on which all other resources are based; however there is need for knowledge about that information. The article examines information and knowledge management. It identifies what exactly is it in knowledge management that is not in information management. Knowledge management requires the association of the knower whilst in information management, the knower might not be really required but documents, articles books and records.
O-09 Soluble triggering receptor expressed on myeloid cells (TREM-1) as a marker of noninfection systemic inflammatory response syndrome (SIRS)

therapy does not influence long-term outcome in diabetic patients undergoing major non-cardiac surgery. Method. With approval of the ethics committees and informed consent, we included 373 diabetic patients undergoing major non-cardiac surgery ( 50% vascular surgery) in this prospective two-centre study. All patients had coronary artery disease (CAD) or were at high risk for it. The primary endpoint was all-cause mortality, and the secondary endpoint was a combination of any major cardiac event (MACE) and all-cause mortality within 12 months. Based on mortality rates of 15-25% [2] a sample size of 350 patients would allow a robust model with 5 variables. Results. The insulin group included 202 (54%) patients, either treated with insulin only (118 patients) or with a combination of insulin and OH (84 patients). A total of 171 (46%) patients were chronically treated with OH only (OH group). Patients in the insulin group had higher revised cardiac risk indices [1] (after exclusion of insulin treatment as a risk factor). During the follow-up of 12 months, 39 (19%) and 22 patients (13%) died in the insulin and the OH group, respectively (P 0.079 [log-rank test]). The secondary endpoint was reached in 70 (35%) and 41 (24%) patients in the insulin and OH groups, respectively, during follow-up (P 0.010). Multivariate analysis showed no association of insulin treatment with mortality (HR 1.52; 95% CI 0.90-2.26; P 0.12), but with the combination of MACE and mortality (HR 1.54; 95% CI 1.05-2.26; P 0.028). Conclusion. Diabetic patients with CAD or at risk for it have a high mortality and cardiovascular morbidity within 12 months after major non-cardiac surgery. Compared with patients treated with OH only, patients treated with insulin or a combination of insulin and OH are at a higher risk due to more associated cardiac risk factors.
Capacity of ‘Femtocell-like’ Secondary System in TV White Space

Here you find some suggested Thesis projects ("Exjobb") suitable for students specializing in Wireless Systems. The collection is not to be seen as complete in any way. The proposals may not all be available at the time you read this, but they still fulfil the function of "placeholders" and examples of what kind of thesis projects can be conducted at the company in question. The contact person listed in the proposals below may in this case have another project available or guide you to some colleague that has. Several of the proposals are about projects that are, or may be, run in cooperation with Wireless@KTH industry partners. Some of the projects or part thereof could also be suitable for Bachelor Theses. Contact the contact person to find out more about the projects.
Grid Connected Photovoltaic Power Plant Controlled By Using FLC and CR with DC-DC Boost Converter

This paper proposes to set up 100 KWp grid connected photovoltaic (PV) power plant. The maximum power point tracking (MPPT) of this PV power plant is controlled by using a proposed combination between the incremental conductance and integral regulator (CR) control and the fuzzy logic control (FLC). This combination is applied to the PV power plant through dc-dc boost converter. The proposed combination collects both advantages of CR and FLC control methods. Whereas the CR control method is simple and widely used for controlling MPPT of PV panels, the FLC provides accurate fast response, high performance and maximum efficiency. Therefore, the combination of these controllers together could improve the MPPT and the PV performance, especially with existing fluctuated solar irradiation and electrical noise. For comparative evaluation, the response of the PV plant with the application of the combined CR and FLC is compared to the responses of the application of each of them separately. The PV plant is simulated using MATLAB and Simulink.
Barcelona GSE Working Paper Series Working Paper n o 909 Investment , Technological Progress and Energy Efficiency

In this paper we propose a macroeconomic model where energy intensity at the macro level responds to changes in energy prices and technological innovations. In our theory this response depends on the interaction between the energy efficiency built in capital goods and the growth rate of Investment Specific Technological Change. ISTC reduces the cost to produce investment goods (extensive margin) and renders them more productive (intensive margin). Higher ISTC acts as an energy saving device. If energy prices stay constant, a permanent increase in the growth rate of ISTC may rise energy intensity in the long run, producing a rebound effect. This is so because the combination of higher ISTC growth rate and constant energy prices makes agents to choose less energy efficient capital goods. Our theory can be used to test when and how we should see a rebound effect in energy use at the aggregate level and can be used to test the aggregate effect of any policy aiming to reduce energy use.
Dielectrically Loaded Quad-Ridge Flared Horn for Beamwidth Control Over Decade Bandwidth—Optimization, Manufacture, and Measurement

We present the design, manufacture, and measured performance of a dielectrically loaded quad-ridge flared horn (QRFH) feed for decade bandwidth radio astronomy application. The introduction of the dielectric load improves the QRFH beamwidth control in H-plane at the mid and upper frequency range. Consequently on the reflector, illumination efficiency, phase efficiency, and the intrinsic cross-polarization ratio (IXR) have been improved. The dielectric load is made from homogeneous low-loss polytetrafluoroethylene and has a low profile with a cylinder shape for simple installation at the center of the QRFH. The dielectrically loaded QRFH presented here covers 1.5–15.5 GHz with a calculated average aperture efficiency above 50% on a f/D = 0.3 prime-focus reflector. We present a calculation of system noise temperature and sensitivity for the QRFH on a 100 m prime-focus reflector. Measured beam patterns of the QRFH are in good agreement with the simulations over the full frequency band. The input reflection coefficient was predicted to be below −10 dB across the bandwidth. We present a tolerance analysis that explains why the measured one deviates.
WST 49.10-T26 CORR

There is a considerable practical interest in phosphorus recovery from water authorities, elementary P-industry, fertilizer industry and regulators in a number of countries. Due to a handful of fullscale plants worldwide, P-recovery can be seen as technically feasible. However, the economic feasibility of P-recovery from sewage can still be judged as dubious. The most important reason for this is that the prices of the techniques (in €/tonne P) are much higher compared to the prices of phosphate rock. In this paper an analysis is given to recover phosphate from municipal wastewater for the elementary P-industry Thermphos International B.V. and the fertiliser industry Amsterdam Fertilizers B.V. in The Netherlands. Several scenarios are evaluated and the end products of these scenarios are compared to the quality required by both industries. From a Dutch study it became clear that all end products from the final sludge treatment do not provide a good source of secondary phosphate. As a consequence of this, the most preferred possibility for P-recovery is to extract phosphate before sludge goes to the final sludge treatment. Different scenarios can be selected based on the position of P-recovery in the WWTP configuration, the type of P-recovery product, and the precipitation technique. Local conditions will determine which scenario is the most expedient. Because it is more realistic to judge a practical situation instead of theoretical estimations based on literature, some local situations have to be assessed in sufficient detail to gain more feeling for the expenses and possible savings of P-recovery. One important actor that should be involved in the process management around P-recovery, is the national government. Especially, the Government have the responsibility for sustainable development and should have attention for some stimulation of P-recovery in The Netherlands. Water authorities and the Pand fertilizer industry made already some good steps.
BUCKLING AND POSTBUCKLING ANALYSIS OF MULTI-WALLED CARBON NANOTUBES BASED ON THE CONTINUUM SHELL MODEL

Buckling and postbuckling behaviors of multi-walled carbon nanotubes (MWCNTs) under a compressive force are studied. MWCNTs are modeled by Donnell’s shallow shell nonlinear theory with the allowance of van der Waals (vdW) interaction between the walls. It is shown herein that the buckling load decreases while the buckling strain increases as the innermost radius of MWCNT increases. For the postbuckling behavior, the shortening-load curves show an initial steep gradient that gradually level up when the radius of the innermost tube changes from a small value to a large value. However, the deflection-load curves are almost level for various radii of MWCNTs. In addition, the analytical results showed that the shortening-load curves are almost linear but the deflection-load curves are nonlinear and the stability of MWCNTs can be enhanced by adding tubes.
Kardioprotektive Mechanismen durch Training - klinische Bedeutung

Cardioprotective Mechanisms by Physical Training – Clinical Significance. Cardiovascular disease is the leading cause of death among women over 65 years and men over 45 years [1]. Regular physical activity using large muscle groups, such as walking, running, swimming, or cycling produces cardiovascular adaptations that increases exercise capacity and skeletal muscle strength. Prospective, epidemiologic studies of physical activity have documented a reduced incidence of coronary artery disease in the more physically active and fit subjects. The most physically active subjects demonstrated coronary artery disease rates half of those of the most sedentary groups [2]. Present data demonstrate a graded relationship of decreasing coronary artery disease rates with increasing levels of activity. Physical activity has a preventive effect and helps treating many established atherosclerotic risk factors, including elevated blood pressure, insulin resistance, and glucose intolerance, elevated LDL cholesterol concentrations, elevated triglyceride concentrations, and obesity. In many studies the lower frequency of coronary artery disease was independent of atherosclerotic risk factors, which implicate additional beneficial effects of exercise training-induced adaptations in the coronary circulation. J Kardiol 2005; 12: 167–9.