Miracle-dz/UniFAR-FTUs huggingface dataset:
Historical Threads in the Development of Oncology Social Work

As the Association of Oncology Social Work celebrates its 25th year, we pause to reflect on the many historical threads that contributed to its development and hear from each of the presidents who helped create the organization, as we know it today. Set within hospitals, medical social work was born in the early 20th century. In the 1940s medical social work became necessary for hospital accreditation. Two additional historical shifts, one in medical improvements in treating cancer, the other a shift to a consumer-oriented American Cancer Society, contributed to the push for a greater role for the federal government in funding cancer research. Oncology social work came to full blossom in the 1970s, a result of the physicians’ need for a member of the health care team who understood cancer, its treatment, and the patient's need to address his or her psychosocial needs resulting from cancer. Today, oncology social work is a fully developed profession with a national organization providing education and support to oncology social workers’ in their use of psychosocial interventions and research in behalf of cancer patients and their families.
Some Observations on Out-patient Psychotherapy

Buckell, M. , and Richardson, J. D. (1950). Brit. J. industr. Med., 7, 131. Dacie, J. V. (1954). The Haemolytic Anaenmas, p. 15. Churchill, London. Gasser, C. (1951). Die h.imolytischen Syndrome im Kindesalter, pp. 65, 177. Thieme, Stuttgart. (1953). Helv. paedlat. Acta, 8, 491. -and Karrer, J (1948). Ibid., 3, 387 and Willi, H. (1952). Ibid., 7, 369. Moeschlin, S. (1941). Folia haemat. (Lpz.), 65, 346. -(1942). Ibid., 66, 308. Parpart, A. K. , Lorenz, P. B. , Parpart, E. R. , Gregg, J. R. , and Chase. A. M. (1947). J. clin. Invest. , 26, 636. Schilling, V. (1928). Z. kiln. Med., 108, 709. Selwyn, J. G. (1955). Brit J. Haemat. , 1, 173. Varadi, S. (1951). J. clin. Path. , 4, 221. Webster, S. H. (1949). Blood, 4, 479. Willi, H. (1947). Schweiz. med. Wschr. , 77, 243. and Hartmeier, F. (1950). Ibid., 80, 1091. Zadek, I. , aid Burg, K. (1930). Folia haemat. (Lpz.), 41, 333.
Reciprocal Empathy and Working Alliance in Terminal Oncological Illness: The Crucial Role of Patients’ Attachment Style

Security of attachment is described as an inner resource that may also facilitate the adaptation of individuals during critical life adversity, even when facing end-stage illness and death. This study assessed the relation between attachment styles, patient–caregiver reciprocal empathy, and patient–physician working alliance, in the terminal phase of an oncological disease. We hypothesized that the attachment security of patients, as measured by the Relationship Questionnaire (RQ), is related to the reciprocal empathy with the caregiver, as measured by the Perception of Partner Empathy (PPE) questionnaire, and to the working alliance with the physician, as measured by the Working Alliance Inventory–Short Form (WAI-S). Thirty-seven end-stage cancer patients, their caregivers, and physicians participated in the study. The PPE and WAI-S were administered twice: immediately after the hospice recovery and a week later. Results showed a significant improvement in patient–caregiver empathy and in patient–physician alliance after a week at the hospice. Findings indicated that the patients’ attachment style influenced their perception of reciprocal empathy with the caregiver and the working alliance with the physician. Patients with a secure attachment had a greater capacity to show empathic closeness with their caregivers and enjoyed a better working alliance with their physicians. Caregivers’ attachment security, otherwise, did not show the same influence on empathy and alliance. Findings support the hypothesis that patients’ attachment security plays a crucial role in the relation with their own caregiver and with the physician, even at the terminal phase. Theoretical and clinical implications of these findings are explored in the discussion.
Influence of fixed prosthodontic treatment on occlusal contacts in centric occlusion: a preliminary study.

Aim: Adequate occlusal contacts are believed to be necessary for dentition function. This study aims to evaluate the impact of prosthodontic treatment on intercuspal occlusal contacts in relation to contact number and contact area. Methodology: The pre-treatment and post-treatment models of 13 patients who underwent fixed prosthodontic treatment on several teeth were retrieved. All the models were scanned by a Micro-CT scanner and 3D virtual images were established. To evaluate the occlusion, the models were virtually articulated. Two occlusion variables were evaluated: (1) contact number and (2) contact area. In addition, the impact of the inter-arch location (maxillary vs. mandibular arches) and intra-arch location (anterior vs. posterior teeth) was assessed. Results: The prosthodontic treatment had significantly increased the contact number and contact area. The effect of the inter-arch location was insignificant. However, the intra-arch location had significantly affected the contact number and area, where the posterior teeth had a significantly greater contact number and area. The posterior teeth were more influenced by the prosthodontic treatment than the anterior teeth, while the anterior teeth were minimally influenced. Conclusion: The prosthodontic treatment improved the quality of occlusal contacts by increasing the contact number and area. The effect of the prosthodontic treatment was more prominent in the posterior region, while, anteriorly, the occlusal variables were minimally affected.
Determinación de la permeabilidad viral de los condones de membrana de poliolefina al bacteriófago Φ Φ Φ ΦX174

En las membranas utilizadas para la fabricacion de los condones existe la posibilidad de encontrar pequenos agujeros, lo cual pone en duda su efectividad como barrera para agentes infecciosos como los virus; por lo anterior, se estandarizo una tecnica fundamentada en la capacidad que tienen los virus bacteriofagos para atravesar membranas e infectar una determinada especie de bacterias, consistente en formar placas de lisis en una capa de crecimiento de la bacteria hospedera, para asi evaluar la capacidad de barrera fisica de sesenta condones de membrana de poliolefina frente a la difusion del bacteriofago FX174(ATCC13706-B1) de 27 nm de diametro, comparandolos con veinte condones de membrana de latex. Se simularon condiciones fisiologicas de presion, pH, tension superficial, longitud y tiempo de exposicion y titulo viral. Para el proceso se diseno un sistema de presurizacion con el cual se inyecto aire comprimido a diez condones en forma simultanea. Se encontro que cuatro de sesenta condones de poliolefinas, y uno de veinte condones de latex fueron permeables al virus, evidenciandose que mas de 93% de los condones evaluados mostraron capacidad de retener el virus. La diferencia de permeabilidad entre los dos tipos de membranas evaluadas no fue estadisticamente significativa (p=0,7897).
The Cornea: Scientific Foundations and Clinical Practice

This new edition is a further improvement on an already outstanding cornea textbook. It is comprised of contributions from 44 well-known clinicians and investigators, including 13 new contributors, many of whom were trained by Claes H. Dohlman, former chairman of the Department of Ophthalmology at the Massachusetts Eye and Ear Infirmary, Harvard Medical School. The updating has resulted in a major revision of many chapters, including those on biochemistry; morphology; the pathological response of corneal disease; bacterial, viral, parasitic, and fungal keratitis; immunology; dermatologic diseases affecting the cornea; corneal and conjunctival tumors; refractive surgery; and contact lens use. The greatest strengths of this comprehensive text are that it addresses the important aspects of the basic sciences and presents an expanded clinical section on corneal and external disease. The editors have provided an extensive bibliography and numerous illustrations (350 black-and-white, 74 color plates) and tables. An additional 82 figures have been
Primary percutaneous coronary intervention of an unprotected left main using mini‐crush drug‐eluting stents facilitated by intracoronary reteplase

Patients suffering from acute myocardial infarction with involvement of unprotected left main (LM) coronary artery disease represent a very high‐risk subgroup. A 37‐year‐old male patient was admitted with posterolateral acute myocardial infarction and in borderline hemodynamic condition. His left ventricular ejection fraction was 30% with posterior, lateral wall, and apical akinesis along with mild mitral regurgitation. Emergency coronary angiography demonstrated ostial occlusion of the left circumflex artery (without stump, flow Thrombolysis in Myocardial Infarction 0/Rentrop 0) and severe distal LM disease with superimposed thrombus. The primary percutaneous coronary intervention procedure combined intracoronary reteplase plus thrombus aspiration to restore flow in the left circumflex and deployment of two everolimus‐eluting stents with mini‐crush technique to successfully reconstruct the LM bifurcation. The patient recovered without complications and had a favorable outcome at mid‐term. © 2011 Wiley‐Liss, Inc.
A 17 Year-Old Man with an Exon 11 Mutation of CD-117 Causing a Gastrointestinal Stromal Tumor

Gastrointestinal stromal tumors (GIST) are tumors most frequently found in adults. They are often related to activating mutations in the CD-117 tyrosine kinase receptor, most commonly at exon 11. Gastrointestinal stromal tumors have been reported in children. However, until recently, there had not been reports of activating mutations in the CD-117 gene, and none have yet documented an exon 11 mutation. We report the case of a 17-year-old found to have an activating mutation in exon 11 of the CD-117 gene. This could play a role in treatment with the targeted therapeutic agent imatinib mesylate.
Anti-Epidermal Growth Factor Receptor Strategies for Advanced Breast Cancer

Significant progress has been achieved in the treatment of breast cancer with therapeutics focused on DNA replication or cell division. Despite the armamentarium of cytotoxic agents, enthusiasm for these agents has been tempered by their lack of tumor cell selectivity, toxicity profile, and almost uniformly the emergence of resistance. In recent years, the focus has shifted to an understanding of cellular signaling pathways involved in carcinogenesis and tumor growth in hopes of allowing the development of targeted cancer drugs. The epidermal growth factor receptor (EGFR) has emerged as an attractive target for the design of targeted therapeutics due to several findings implicating their involvement in the development and progression of cancer (1–3). The activation of EGFR signaling pathways is known to increase proliferation, angiogenesis, and decrease apoptosis. Several strategies directed at the EGFR have been investigated in the clinical setting. These include monoclonal antibodies that block ligand binding to receptors and small molecule adenosine triphosphate (ATP) competitive inhibitors of the receptor tyrosine kinase. This chapter will review the current data on tyrosine kinase inhibitors in the management of advanced breast cancer. Attention will be directed at understanding the molecular mechanisms of these agents balanced with their application to clinical practice.
Clostridium difficile colitis: factors influencing treatment failure and relapse—a prospective evaluation

Objective:The aim of this study was to identify patient related factors that may influence the treatment response and relapse following Clostridium difficile (C. difficile) colitis.Methods:A total of 36 patients with C. difficile colitis were followed for 3 months. Age, sex, place of residence, severity of infection, treatment, underlying medical condition, and treatment were compared in patients who failed to respond to treatment in 14 days and in patients who relapsed after a successful treatment. Student's t test and Fisher's exact test were used to compare the groups. A p value of <0.05 was considered significant.Results:A low serum albumin (p= 0.016) and continuation of systemic antibiotic treatment were found to be associated with refractoriness to treatment. Continuation or restarting of antibiotics after successful treatment increases the risk of relapse (p= 0.003). The age, sex place of residence, underlying medical condition, and type of precipitating antibiotics had no effect on the treatment response and relapse. The severity of colitis and the type of therapy (metronidazole vs vancomycin) did not influence the treatment response or relapse.Conclusion:Low serum albumin serves as a useful marker for patients who require prolonged treatment for C. difficile colitis. It is prudent to review the need for the continuation of systemic antibiotic treatment, as it adversely affects the treatment response and increases the risk of relapse.
Prediction of outcomes after percutaneous coronary intervention for unprotected left main coronary artery stenosis using the EuroSCORE

The EuroSCORE, designed to predict surgical mortality, was recently shown to be an independent predictor of adverse outcomes after percutaneous coronary intervention (PCI) [1]. Rekik et al. confirmed, in this issue, that EuroSCORE had a function to predict mortality after PCI for 246 patients with unprotected left main coronary artery (ULMCA) stenosis [2]. The predictive power of 4-year survival was modest with the c-statistic of 0.69 in the entire population. Of interest, when the patients were separated into the low and high score groups by six of EuroSCORE, the performance of EuroSCORE to predict mortality was better in the high score group with the c-statistic of 0.71 than the low score group with the c-statistics of 0.65. Accordingly, this study reports the strength and weakness of EuroSCORE risk scoring system when it is utilized in individual care of patients with complex coronary disease. Because the EuroSCORE is a risk assessment system to integrate the diverse clinical and procedural factors of patients, it is not surprising to find the predictive ability of EuroSCORE in PCI for ULMCA stenosis [2]. However, with regard to the generalizability of this score in all interventions, its limitations need to be concerned. Because, the EuroSCORE was basically developed to predict operative mortality in open heart surgery, some components of this score may not be applicable to the prediction of PCI. For instance, procedural factors, such as cardiac surgery except coronary artery bypass surgery (CABG), surgery on thoracic aorta or postinfact septal rupture, are not considered prognostic factors of PCI. In addition, because this score was initially created with the CABG database, integers weighting the clinical importance of prognostic factors may not be reasonable in the procedures of PCI. Finally, the differential predictability according to the level of EuroSCORE, as indicated in the paper of Rekik et al, is another limitation. A lower predictive power of low EuroSCORE for operative mortality was already reported in the previous analysis evaluating studies including CABG patients [3]. In particular, because the distribution of EuroSCORE in PCI patients is generally clustered in the low scores, the performance as a risk prediction model may not be sufficiently high in patients with low EuroSCORE. Despite aforementioned illustration about the limitations of EuroSCORE, it is noteworthy that this scoring system is still one of the most validated risk models in either CABG or PCI [1]. For high risk patients, such as those with ULMCA disease, applying such a risk score is clinically relevant to decide appropriate treatment strategy and predict outcome. In fact, a recent study reported that a combination of SYNTAX score and EuroSCORE can improve the performance of risk prediction [4,5]. Therefore, in a daily patient care, assessment of carefully collected data with application of current risk scoring models would be clinically important before a single ideal risk model is created.
Intracoronary bolus‐only compared with intravenous bolus plus infusion of tirofiban application in patients with ST‐elevation myocardial infarction undergoing primary percutaneous coronary intervention

Objectives: The aim of this pilot study was to compare intracoronary bolus‐only with standard intravenous bolus plus maintenance infusion of tirofiban with respect to improvement in myocardial reperfusion after primary percutaneous coronary intervention (p‐PCI). Background: Changes in clinical practice may obviate the need for a maintenance infusion of small molecule glycoprotein IIb/IIIa inhibitors in current practice. Methods: Forty‐nine patients undergoing p‐PCI were randomized to either intracoronary bolus‐only (n = 25) or intravenous bolus plus infusion (n = 24) of tirofiban. The primary end point was coronary hemodynamic indices of microvascular perfusion measured 4–5 days after p‐PCI. The secondary end points were ST segment resolution at 90 min, the corrected TIMI frame count and myocardial blush grade. At 6 months, echocardiography and technetium‐99m single‐photon‐emission computed tomography were performed. Results: Microvascular perfusion did not differ significantly between the two treatment groups: index of microvascular resistance (27 ± 13 vs. 35 ± 15 U, P = 0.08) and coronary flow reserve (2.2 ± 0.7 vs. 1.9 ± 0.6, P = 0.25). The corrected TIMI frame counts assessed in the first (P = 0.13) and the second (P = 0.09) catheterization or the myocardial blush grades evaluated immediately (P = 0.23) and 4–5 days after MI (P = 1.00) were not significantly different between the two groups. At 6 months, there was no difference between the two groups in infarct size, left ventricular volumes, or ejection fraction. Conclusions: The standard intravenous bolus plus maintenance infusion of tirofiban in p‐PCI is not superior to intracoronary bolus‐only administration with respect to microvascular perfusion. Further, adequately powered randomized trials are warranted to evaluate the clinical outcomes associated with this strategy. © 2011 Wiley Periodicals, Inc.
A First Report of Radioembolization for Hepatic Metastases From Ocular Melanoma

Background: Ocular melanoma (OM) metastasizes to the liver and is rapidly fatal despite aggressive therapy. Yttrium-90 microspheres (radioembolization) delivered via the hepatic artery is an established and effective approach for primary and metastatic hepatic tumors, although 90Y use in OM has not been reported previously. Methods: A retrospective review was performed for all patients with OM who received radioembolization at 5 centers. Results: 11 patients received 12 treatments with a median activity of 1.55 GBq delivered per treatment. Toxicity was minimal, with PET/CT at 3 months posttreatment showing a response in all patients; 1 patient had a complete response. Conclusions: Radioembolization can control hepatic metastases of OM with very few side effects.
Hybrid therapy for interrupted aortic arch with aortopulmonary window in a low birth weight infant

Interrupted aortic arch (IAA) is rarely associated with aortopulmonary window. Single‐stage total correction is the preferred therapeutic option. When total correction is unfeasible, staged repair could be the therapeutic choice. Here, we presented a low birth weight infant who underwent bilateral pulmonary arteries banding and stenting ductus arteriosus by hybrid procedure. Hybrid procedure avoids long‐term central line insertion and guarantees ductal flow. It also avoids the side effects from prostaglandin infusion. © 2011 Wiley Periodicals, Inc.
Epidemiologic Studies of Tooth Morphology

For the purpose of this report, the term "tooth morphology" refers not only to the number and shape of cusps, ridges, and grooves, but also to tooth size as a whole. Size and shape of teeth cannot be easily separated.1 2 For example, at least in the mesiodistal dimension, the molar crown size reflects the degree of development of the highly variable distal cusps. Tooth morphologic variations in man range in degree from rather minor differences, detectable bilaterally in the same individual, to gross tooth deformities and anodontia. The dentition of man appears to be undergoing evolutionary changes which vary in intensity between races and between individuals of the same race. ' The purpose of this report is to elucidate the importance of variations in tooth morphology to clinical dentistry and dental science, and to weigh the evidence regarding the relative importance of heredity and environmental factors responsible for the variations.
Factors Influencing Healthy Eating Habits Among College Students: An Application of the Health Belief Model

Poor eating habits are an important public health issue that has large health and economic implications. Many food preferences are established early, but because people make more and more independent eating decisions as they move through adolescence, the transition to independent living during the university days is an important event. To study the phenomenon of food selection, the heath belief model was applied to predict the likelihood of healthy eating among university students. Structural equation modeling was used to investigate the validity of the health belief model (HBM) among 194 students, followed by gender-based analyses. The data strongly supported the HBM. Social change campaign implications are discussed.
2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention: Executive Summary

WRITING COMMITTEE MEMBERS* Glenn N. Levine, MD, FACC, FAHA, Chair, Eric R. Bates, MD, FACC, FAHA, Vice Chair*, James C. Blankenship, MD, FACC, FSCAI, Vice Chair*, Steven R. Bailey, MD, FACC, FSCAI*, John A. Bittl, MD, FACC, Bojan Cercek, MD, FACC, FAHA, Charles E. Chambers, MD, FACC, FSCAI, Stephen G. Ellis, MD, FACC*, Robert A. Guyton, MD, FACC*, Steven M. Hollenberg, MD, FACC*, Umesh N. Khot, MD, FACC*, Richard A. Lange, MD, FACC, FAHA, Laura Mauri, MD, MSC, FACC, FSCAI*, Roxana Mehran, MD, FACC, FAHA, FSCAI*, Issam D. Moussa, MD, FACC, FAHA, FSCAI, Debabrata Mukherjee, MD, FACC, FSCAI, Brahmajee K. Nallamothu, MD, FACC, Henry H. Ting, MD, FACC, FAHA
EXTRACTING CONTEXTUALIZED COMPLEX BIOLOGICAL EVENTS WITH RICH GRAPH‐BASED FEATURE SETS

We describe a system for extracting complex events among genes and proteins from biomedical literature, developed in context of the BioNLP’09 Shared Task on Event Extraction. For each event, the system extracts its text trigger, class, and arguments. In contrast to the approaches prevailing prior to the shared task, events can be arguments of other events, resulting in a nested structure that better captures the underlying biological statements. We divide the task into independent steps which we approach as machine learning problems. We define a wide array of features and in particular make extensive use of dependency parse graphs. A rule‐based postprocessing step is used to refine the output in accordance with the restrictions of the extraction task. In the shared task evaluation, the system achieved an F‐score of 51.95% on the primary task, the best performance among the participants. Currently, with modifications and improvements described in this article, the system achieves 52.86% F‐score on Task 1, the primary task, improving on its original performance. In addition, we extend the system also to Tasks 2 and 3, gaining F‐scores of 51.28% and 50.18%, respectively. The system thus addresses the BioNLP’09 Shared Task in its entirety and achieves the best performance on all three subtasks.