Miracle-dz/UniFAR-FTUs huggingface dataset:
Antifungal management in adults and children with hematological malignancies or undergoing hematopoietic cell transplantation: recommendations of Polish Society of Hematology and Blood Transfusion, Polish Society of Pediatric Oncology and Hematology, and Polish Adult Leukemia Study Group, 2020

Abstract Invasive fungal disease (IFD) is one of the most serious complications of therapy in patients with immune suppression. It particularly concerns patients treated for malignant hematological diseases, immune deficiencies, or undergoing hematopoietic cell transplantation (HCT). Development of IFD can abrogate the effect of previous therapy and contributes to dismal outcome of the underlying disease. The Working Group consisting of members of the Polish Society of Hematology and Blood Transfusion, the Polish Society of Pediatric Oncology and Hematology, and the Polish Adult Leukemia Study Group has prepared recommendations for the diagnostic and therapeutic management of IFD in adults and children. This paper presents the current recommendations for patients in immune suppression treated in Polish pediatric and adult hematology and HCT centers, based on the guidelines of the European Conference on Infections in Leukaemia (ECIL) 2015–2019. Levels of diagnosis of IFD (possible, probable, and proven) and antifungal management (prophylaxis, as well as empirical and targeted therapies) are declared according to updated international criteria of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group (EORTC/MSG) 2019. Patients with primary diagnosis of acute lymphoblastic leukemia, acute myeloblastic leukemia, severe aplastic anemia, chronic granulomatous disease, and severe combined immunodeficiency, as well as patients after allogeneic HCT, are included in the high-risk groups for development of IFD. For these patients, antifungal prophylaxis based on azoles or micafungin is recommended. In empirical therapy, caspofungin or liposomal/lipid formulas of amphotericin B are recommended. The Working Group has discouraged the use of itraconazole in capsules and amphotericin deoxycholate. Detailed guidelines for first- and second-line targeted therapies for invasive candidiasis, aspergillosis, mucormycosis, fusariosis, and scedosporiosis, as well as the principles of the recommended dosing of antifungals, are presented in this paper.
Polymer-Bioactive Glass Composite Filaments for 3D Scaffold Manufacturing by Fused Deposition Modeling: Fabrication and Characterization

Critical size bone defects are regularly treated by auto- and allograft transplantation. However, such treatments require to harvest bone from patient donor sites, with often limited tissue availability or risk of donor site morbidity. Not requiring bone donation, three-dimensionally (3D) printed implants and biomaterial-based tissue engineering (TE) strategies promise to be the next generation therapies for bone regeneration. We present here polylactic acid (PLA)-bioactive glass (BG) composite scaffolds manufactured by fused deposition modeling (FDM), involving the fabrication of PLA-BG composite filaments which are used to 3D print controlled open-porous and osteoinductive scaffolds. We demonstrated the printability of PLA-BG filaments as well as the bioactivity and cytocompatibility of PLA-BG scaffolds using pre-osteoblast MC3T3E1 cells. Gene expression analyses indicated the beneficial impact of BG inclusions in FDM scaffolds regarding osteoinduction, as BG inclusions lead to increased osteogenic differentiation of human adipose-derived stem cells in comparison to pristine PLA. Our findings confirm that FDM is a convenient additive manufacturing technology to develop PLA-BG composite scaffolds suitable for bone tissue engineering.
Bagging Chopped Lettuce in Selected Permeability Films

(.) Discoloration and off-flavors developed in lettuce stored in the two films in which the naturally produced CO 2 rose above 20%. In the two films (oriented low-density polyethylene) with O 2 transmission rates higher than 3000 ml . m −2. day -1. atm -1 at 22C, CO 2 remained below 20%, O 2 was between ≤2% and 15%, and the lettuce was acceptable after 14 days of storage at either 1 or 5C. Appearance and flavor were affected more by temperature than by lengh of storage
Agroecological Transitions: A Mathematical Perspective on a Transdisciplinary Problem

In the face of climate change, rising hunger and mass extinctions, scholars stress the need to transition food systems from fossil fuel-dependent conventional farms to agroecological alternatives that can store carbon, improve food security and harbor biodiversity. Theory provides a systematic approach for organizing knowledge on agroecological transitions across the natural and social sciences and summarizing the primary needs of future research. This paper reviews the socio-ecological literature related to agroecological transitions from a mathematical perspective that is derived from complex systems and critical transition theory. We organize the literature according to mathematically tractable concepts, including syndromes of production, agents, barriers and drivers of change that operate across three major frameworks of analysis: socio-ecological, socio-technological and social norms and networks. Our approach embeds the current agroecological transition theory within a critical transition framework that considers the stability of peasant and capitalist syndromes in response to various inhibitors and drivers of change. We find that the majority of our theoretical knowledge of food systems change is derived from the social sciences and limited primarily to examples from the Americas. Our work suggests a need for broader regional representations of change and transdisciplinary work aimed at better understanding how biophysical factors collide with socio-political conditions to hinder or reverse food systems change. Though scale and context are important considerations, we find that theory can generate general mechanisms that link separate case studies. For example, drivers of food systems change that shift balances between the costs and benefits of peasant and capitalist modes of production may be particularly important for explaining poverty and gilded traps in agriculture. We discuss this and other lessons learned from taking a theoretical perspective on agroecological transitions.
The Ecology of the Human Intestine and its Consequences for Overgrowth by Pathogens such as Clostridium Difficile

Article de synthese. Etude des divers aspects de l'ecologie microbienne de l'intestin dans des modeles animaux. Developpement de la flore intestinale apres la naissance. Facteurs ecologiques associes a la colonisation de l'intestin par Clostridium difficile
How Well Does Sky Harbor International Airport Characterize Winter Precipitation in the Phoenix Area?

Abstract Sky Harbor International Airport (SKA) is the first-order weather station in the Phoenix metropolitan area. Meteorological variables from the weather station, including precipitation, are reported by the media to the general public as the official weather results for the Phoenix metropolitan area, which measures more than 15,000 square miles. While temperature is a continuous meteorological parameter that does not vary much spatially across Phoenix, precipitation is a discrete and more variable weather phenomenon, even during winter, when mid-latitude storms bring wide swaths of precipitation to Arizona. Does the precipitation measured at Sky Harbor International Airport spatially characterize precipitation in the rest of the Phoenix area during winter? Have correlations between Sky Harbor winter precipitation and the rest of the Phoenix area changed over time? Precipitation data for the months of December to March were compiled for 28 Phoenix area weather stations for the time period 1990–2004 and for 8 stations from 1954–2004. Five definitions of precipitation, including total, frequency, intensity, duration, and true intensity were developed to define precipitation. Regression equations using Sky Harbor precipitation as the independent variable were run to determine correlations and variance explained with surrounding stations. Additional regressions were run on subsets of the 1954–2004 data to determine if correlations have changed over time. Overall, Sky Harbor explains between 71 to 99% of total seasonal precipitation and between 85 to 98% of the seasonal frequency, although these numbers are significantly reduced for daily data. Locations closer to Sky Harbor are more highly correlated for all variables than those farther away. Correlation coefficients show significant changes due to the urban heat island as well from climate teleconnections.
The Changing Profile of Indian Boards

The Cod bury committee report (1992) placed the corporate board at the centre stage of the governance system that it described as one by which companies are directed and governed. A major port of the debate on corporate governance centres around board composition especially board size and independence. Corporate governance reforms in the US and the UK hove focused on making the board independent of the Chief Executive Officer (CEO) and hence on independent directors. The Cadbury Committee (1992), the Greenbury Committee (1995), the Hampel Committee (1998), the Higgs Committee (2003), etc. have mandated independent directors on the board. Guidelines have been issued in India on the composition of the board of directors that are on similar lines as those given abroad, mandating the appointment of a certain percentage of independent directors. The SEBI Guidelines on Corporate Governance based on the report of the Kumar Mangalam Birla Committee and recommendations of subsequent committees, namely, the Naresh Chandra Committee, the N.R. Narayana Murthy Committee, and very recently, the J.J. Irani Committee have given a mandate for independent directors. Literature finds that smaller boards are more efficient than larger ones. A larger board impairs the performance of the firm. This paper documents the changing profile of the boards of Indian companies in the light of the guidelines on board composition which have been given by various statutory bodies and committees.
Selecting Parameters in Performance-Based Ground Delay Program Planning

In this paper, we consider the problem of selecting a set of parameters for a Ground Delay Program so that the program achieves a vector of performance objectives that is similar to a target vector. This could be used to support consensus-based ground delay program planning. We propose a method that selects several potential candidates of vectors, and we compare our method with a simple greedy algorithm. Our results indicate that our proposed method is able to provide multiple solutions that are closer to the efficient frontier than the
Disparities in Sepsis Outcomes: A Problem in Need of Solutions.

Critical Care Medicine www.ccmjournal. org 1079 screening checklist (ICDSC) for the diagnosis of delirium: A systematic review and meta-analysis of clinical studies. Crit Care 2012; 16:R115 15. Morandi A, Brummel NE, Ely EW: Sedation, delirium and mechanical ventilation: The ‘ABCDE’ approach. Curr Opin Crit Care 2011; 17:43–49 16. Rosa RG, Falavigna M, da Silva DB, et al; ICU Visits Study Group Investigators and the Brazilian Research in Intensive Care Network (BRICNet): Effect of flexible family visitation on delirium among patients in the intensive care unit: The ICU visits randomized clinical trial. JAMA 2019; 322:216–228 17. Rosa RG, Tonietto TF, da Silva DB, et al; ICU Visits Study Group Investigators: Effectiveness and safety of an extended ICU visitation model for delirium prevention: A before and after study. Crit Care Med 2017; 45:1660–1667 18. Jabre P, Belpomme V, Azoulay E, et al: Family presence during cardiopulmonary resuscitation. N Engl J Med 2013; 368:1008–1018 19. Kleinpell R, Zimmerman J, Vermoch KL, et al: Promoting family engagement in the ICU: Experience from a national collaborative of 63 ICUs. Crit Care Med 2019; 47:1692–1698
Hierarchical Clustering for Image Classification in Dermatology: Towards Mobile Deploying

In the context of increasing interest in computer-assisted diagnosis for skin lesion images and mobile applications to be used in real life settings, we propose a combined desktop-smartphone solution for dermatological image classification. Hierarchical agglomerative and divisive clustering are both implemented as methods of cluster analysis, with the RGB color histogram as descriptor for a global image analysis. The cosine similarity is employed for classifying the query image in one of the available clusters, characterized by their centroids. The solution has been tested with a public database of dermoscopic images, with an overall accuracy of 0.73, 95%CI (0.58;0.85).
Editorial

The survival of firms depends on their ability to innovate (Rubera and Kirca, 2012). Yet the failure rate of new products and new services remains high. The Product Development and Management Association (PDMA) has estimated the failure rate of new products in three successive studies (Barczak et al., 2009; Griffin, 1997; Page, 1993) and found that this rate has remained stable at around 40%. This 2016 special issue of Recherche et Applications en Marketing is intended to encourage studies that will allow us to better understand how companies can successfully innovate with a view to sustaining their long-term growth. Specifically, further research on innovation strategies seems to be essential for better understanding of how a company can effectively (1) combine the technological dimension of innovation with that of demand, (2) create a culture that encourages innovation throughout the organization, (3) organize its innovation activities, and (4) launch its innovations (Gatignon et al., 2015). Of these four themes, the six articles in this special issue address the question of the organization of innovation activities. Specifically, they focus on how to optimize the process of generating innovation opportunities. If a company’s capacity to generate “good” ideas for new products or services determines the success of its innovations (Evanschitzky et al., 2012), one of the major challenges for a firm that wants to innovate sustainably is to be able to continuously generate such innovation opportunities. This first stage of the innovation process is particularly difficult – only 14% of new product ideas become commercially successful (Barczak et al., 2009) – so much so that it is often called the “fuzzy front end” of the innovation process (e.g. Montoya-Weiss and O’Driscoll, 2000; Soukhoroukova et al., 2012). One way to continuously generate opportunities for innovation is to organize new product or new service development teams so as to make them more creative. Within the framework of a new product or new service development process, forming new product development teams is still a prevailing practice. Research has long been concerned with the effects of composing and managing new product development teams on innovation performance (Gatignon et al., 2015). In the specific context of creativity for generating ideas for new products or services, the paper by Maud Dampérat, Florence Jeannot, Eline Jongmans and Alain Jolibert, titled Team creativity: creative self-efficacy, creative collective efficacy and their determinants, explores the mechanisms underlying teams’ creativity. In particular, the authors propose and test an integrative model of individual and collective creative effectiveness (Bandura, 1977, 2007). From this they identify and hierarchize the drivers of individual creative effectiveness – with an emphasis on knowledge gained through experience – and demonstrate the impact of individual creative effectiveness on collective creative effectiveness. Furthermore, the authors clarify the effect that social proximity between team members has on collective creative team effectiveness. As a result, the paper advances Editorial
Data Integration into OMOP CDM for Heterogeneous Clinical Data Collections via HL7 FHIR Bundles and XSLT

Data integration is an important task in medical informatics and highly impacts the gain out of existing health information data. These tasks are using implemented as extract transform and load processes. By introducing HL7 FHIR as an intermediate format, our aim was to integrate heterogeneous data from a German pulmonary hypertension registry into an OMOP Common Data Model. First, domain knowledge experts defined a common parameter set, which was subsequently mapped to standardized terminologies like LOINC or SNOMED-CT. Data was extracted as HL7 FHIR Bundle to be transformed to OMOP CDM by using XSLT. We successfully transformed the majority of data elements to the OMOP CDM in a feasible time.
THE CHEMICAL CONTROL OF POSTHARVEST DISEASES: Deciduous Fruits, Berries, Vegetables and Root/Tuber Crops

In the preface of his thought-provoking book The Vanishing Harvest (235), R. K. Robinson offers this relevant insight, "Over the last twenty to thirty years, agricultural production has increased dramatically, and yet interest in the protection of crops against postharvest losses has never gained the same momentum. Some wastage of crops or animal produce is, by the very nature of the harvesting processes, inevitable, but the avoidable losses 'between the farm gate and the consumer' give cause for real concern. " International agencies that monitor world food resources have acknowl­ edged that one of the options most feasible for meeting future food needs is the reduction of postharvest losses (158). Fresh fruits, vegetables, roots, and tubers are quite perishable because their high moisture content makes them vulnerable to microbial decay as well as to physiological deterioration (123). While actual losses vary from season to season in all production areas, overall losses are highest in developing countries of the tropics where transportation and refrigeration facilities are likely to be minimal (64). Even in societies with access to the most advanced technologies for handling fresh produce, postharvest losses continue to be substantial (41, 123). A series of papers
Gliding Flight of the White-Backed Vulture Gyps Africanus

1. Glide-comparison measurements were made on ten species of East African soaring birds using a Schleicher ASK-14 powered sailplane. Horizontal and vertical speed differences between bird and glider were measured by a photographic method, and used to estimate the bird9s horizontal and vertical speeds relative to the air. The analysis refers to the white-backed vulture, since by far the largest number of measurements was obtained on this species. 2. A regression analysis using a two-term approximation to the glide polar yielded an implausibly high estimate of induced drag, which was attributed to a lack of observations at lift coefficients above 0.72. An amended glide polar was constructed assuming elliptical lift distribution and a maximum lift coefficient of 1.6 to define the low-speed end, while the high-speed end was made to pass through the mean horizontal and sinking speeds of all the experimental points. This curve gave a minimum sinking speed of 0.76 m/s at a forward speed of 10 m/s, and a best glide ratio of 15.3:1 at 13 m/s. It did not differ significantly (in the statistical sense) from the original regression curve. 3. In comparing the estimated circling performance, based on the amended glide polar, with that of the ASK-14, it was concluded that the rates of sink of both should be comparable, but that the glider would require thermals with radii about 4.3 times as great as those needed to sustain the birds. The conclusions are consistent with experience of soaring in company with birds. 4. In an attempt to assess the adaptive significance of the low-aspect-ratio wings of birds specializing in thermal soaring, the white-backed vulture9s circling performance was compared with that of an ‘albatross-shaped vulture’, an imaginary creature having the same mass as a white-backed vulture, combined with the body proportions of a wandering albatross. It appears that the real white-back would be at an advantage when trying to remain airborne in thermals with radii between 14 and 17 m, but that the albatross-shaped vulture would climb faster in all wider thermals; on account of its much better maximum glide ratio, it should also achieve higher cross-country speeds. It is concluded that the wing shape seen in vultures and storks is not an adaptation to thermal soaring as such, but is more probably a compromise dictated by take-off and landing requirements. 5. The doubts recently expressed by Tucker & Parrott (1970) about the results and conclusions of Raspet (1950 a , b ; 1960) are re-inforced by the present experience.
Treatment of adhesions after Achilles tendon injury using focused ultrasound with targeted bFGF plasmid-loaded cationic microbubbles

Abstract Nonviral targeting technology has become promising as a form of gene therapy for diseases and injuries, such as Achilles tendon injuries. In this study, we used avidin–biotin bridge and positive–negative charge attractions to load the intercellular adhesion molecule-1 (ICAM-1) antibody and the basic fibroblast growth factor (bFGF) plasmid onto the surface of the microbubbles. The saturated loading capacity for 1.1 × 108 microbubble was 6.55 ± 0.53 µg. We established the ICAM-1 antigen microenvironment using tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells and found the targeting ability of the prepared microbubbles in vitro. In vivo, we also found that the injected targeted bFGF gene microbubbles expressed the bFGF gene better when compared with that of the control group. Furthermore, we evaluated adhesions after Achilles tendon injuries in rabbits using hematoxylin and eosin and immunohistochemical (IHC) staining methods. The collagen fibers were properly arranged in the tendon, and there was greater cellularity inside the tendon sheath and a clearer boundary between the internal and external tendon sheath than that of the control group. IHC staining showed greater ICAM-1 expression inside the tendon sheath when compared with outside the tendon sheath. In conclusion, targeted microbubbles can be a useful carrier of genes to provide gene therapy for the prevention of adhesions after tendon injury.
Exploration and Research of Human Identification Scheme Based on Inertial Data

The identification work based on inertial data is not limited by space, and has high flexibility and concealment. Previous research has shown that inertial data contains information related to behavior categories. This article discusses whether inertial data contains information related to human identity. The classification experiment, based on the neural network feature fitting function, achieves 98.17% accuracy on the test set, confirming that the inertial data can be used for human identification. The accuracy of the classification method without feature extraction on the test set is only 63.84%, which further indicates the need for extracting features related to human identity from the changes in inertial data. In addition, the research on classification accuracy based on statistical features discusses the effect of different feature extraction functions on the results. The article also discusses the dimensionality reduction processing and visualization results of the collected data and the extracted features, which helps to intuitively assess the existence of features and the quality of different feature extraction effects.