Miracle-dz/UniFAR-FTUs huggingface dataset:
A pipelined, multiprocessor architecture for a connectionless server for broadband ISDN

The direct provision of connectionless service in BISDN calls for servers that are connected to or are part of an ATM network to provide the routing function at input speeds up to 622 Mb/s. Routing is achieved in such a server by changing the VCI/VPI headers in the ATM cells; actual switching is done by existing switches in the ATM network. The paper presents an architecture capable of executing all the functions of a server at input speeds up to 622 Mb/s, scalable to multiple inputs at that speed, making use of processors and special hardware that are available today. To avoid storing large quantities of data, the architecture routes data packets by examining routing information in the initial cell of the packet and routing subsequent cells as they arrive rather than waiting until the complete packet has arrived. It is capable of handling packets that have been multiplexed at the SAR sublayer using AAL Type 3/4 and, with minor modifications, could also handle Type 5 traffic. Arguments are also presented for the use of AAL Type 5 for the direct connectionless service. >
Use of muscle exudates for the detection of anti-gE antibodies to Aujeszky's disease virus

A commercial ELISA test to detect serum anti-gE antibodies to Aujeszky's disease virus was adapted for use with muscle exudates. The muscle samples were taken from the diaphragm of pig carcases at the slaughterhouse. Three hundred and eightynine pairs of samples of serum and muscle exudate were compared to determine the possibility of using muscle exudate samples in a programme to control Aujeszky's disease. Taking the serum samples as the reference, the individual sensitivity of the test was 93-2 per cent and the individual specificity was 98-3 per cent. The concentration of antibodies in the muscle exudates was on average 20 times lower than that in the serum samples.
On Graph Mining With Deep Learning: Introducing Model R for Link Weight Prediction

Abstract Deep learning has been successful in various domains including image recognition, speech recognition and natural language processing. However, the research on its application in graph mining is still in an early stage. Here we present Model R, a neural network model created to provide a deep learning approach to the link weight prediction problem. This model uses a node embedding technique that extracts node embeddings (knowledge of nodes) from the known links’ weights (relations between nodes) and uses this knowledge to predict the unknown links’ weights. We demonstrate the power of Model R through experiments and compare it with the stochastic block model and its derivatives. Model R shows that deep learning can be successfully applied to link weight prediction and it outperforms stochastic block model and its derivatives by up to 73% in terms of prediction accuracy. We analyze the node embeddings to confirm that closeness in embedding space correlates with stronger relationships as measured by the link weight. We anticipate this new approach will provide effective solutions to more graph mining tasks.
Passenger Bus Navigation and Assistance Providing System for Blind People

In this paper we propose a passenger bus navigation system using Wireless Sensor Network (WSNs). This System comprises of three Units: Bus Station Unit, Bus Unit and Blind Unit. The Blind people on the Bus Station are provided with a Blind Unit. The blind speaks his destination on the microphone provided on the Bus Station Unit. When the desired bus stops at the station for the Blind, then via voice synthesizer the recorded indication is made for blind to reach on the bus. After reaching on the bus, if Blind wants any help like medicine, water or any specific need then there are Push Buttons available on the Blind Unit. By pressing this Push Buttons Blind person can get assistance from available options. Now when bus reaches at any station, it will check at every station for blind person‟s destination. Whenever match occurs then Blind will be notified via recorded voice via voice synthesizer. This system is also useful for the elder people. Key words-Wireless sensor Networks (WSNs), Zigbee, Voice Recognition System, RFID, Voice Synthesizer
ZBTB7B (Th-POK) Regulates the Development of IL-17–Producing CD1d-Restricted Mouse NKT Cells

CD1d-dependent NKT cells represent a heterogeneous family of effector T cells including CD4+CD8− and CD4−CD8− subsets that respond to glycolipid Ags with rapid and potent cytokine production. NKT cell development is regulated by a unique combination of factors, however very little is known about factors that control the development of NKT subsets. In this study, we analyze a novel mouse strain (helpless) with a mis-sense mutation in the BTB-POZ domain of ZBTB7B and demonstrate that this mutation has dramatic, intrinsic effects on development of NKT cell subsets. Although NKT cell numbers are similar in Zbtb7b mutant mice, these cells are hyperproliferative and most lack CD4 and instead express CD8. Moreover, the majority of ZBTB7B mutant NKT cells in the thymus are retinoic acid–related orphan receptor γt positive, and a high frequency produce IL-17 while very few produce IFN-γ or other cytokines, sharply contrasting the profile of normal NKT cells. Mice heterozygous for the helpless mutation also have reduced numbers of CD4+ NKT cells and increased production of IL-17 without an increase in CD8+ cells, suggesting that ZBTB7B acts at multiple stages of NKT cell development. These results reveal ZBTB7B as a critical factor genetically predetermining the balance of effector subsets within the NKT cell population.
Estimating Tool Damage & Remaining Useful Life of a CNC milling cutter by applying Time-Frequency Analysis, Machine Learning and Evolutionary Optimization

The constant evolution of machinery and the increased degree of automation along with advances in technological knowledge have given rise to predictive maintenance (PM), a maintenance scheme that can diagnose the current state of machinery or even predict its remaining life based on collected data. In the scope of this thesis, a PM framework is designed for the estimation of tool damage and remaining tool life in CNC milling machine cutters, based on collected time-series data measuring force, vibration and acoustic emissions after each cut. Time-domain, frequency-domain and time-frequency domain features are extracted from the time-series. For the latter case, Wavelet Transform is used since it is much more suitable than Fourier Transform and its variants for time-frequency analysis of non-stationary signals. Further feature selection and feature transformation techniques are applied with the aim of dimensionality reduction and ultimately a final subset with relevant and non-redundant features. In all cases, a necessary transformation for the problem at hand is to take the cumulative values of the features, therefore adding all previous values to a feature’s value. The final feature set is then used as input to a proposed modification of Extreme Learning Machine (ELM), a single layer feedforward network that performs learning of the connecting weights without iterations. A modification of ELM, ES-RELM is proposed which uses regularization and modified Evolutionary Strategy (ES) in order to find a stable model that can predict tool wear sufficiently for different test sets. ES-RELM significantly improves the generalization capabilities of the found optimal regression model and clearly outperforms ES-ELM, a similar methodology without the use of regularization. The feature set that performs best is acquired after PCA performed at the whole feature set, since it projects the feature set into 4 independent features, thus resulting in nonredundant features. Last but not least, recommendations for future research regarding all main parts of the framework are proposed.
Early postmyocardial infarction survival in Murphy Roths Large mice is mediated by attenuated apoptosis and inflammation but depends on genetic background

The Murphy Roths Large (MRL) mouse, a strain capable of regenerating right ventricular myocardium, has a high postmyocardial infarction (post‐MI) survival rate compared with C57BL/6J (C57) mice. The biological processes responsible for this survival advantage are unknown. To assess the effect of genetic background, the LG/J strain, which harbours 75% of the MRL composite genome, was included in the study. The MRL survival advantage versus C57 mice (92 versus 68%, P < 0.05) occurred primarily in the first 5 days; LG/J survival was intermediate (P= n.s.). Microarray data analysis revealed an attenuation of apoptotic (P < 0.05) and stress response transcripts in MRL hearts compared with C57 hearts post‐MI. Supporting the microarray results, there were fewer TUNEL‐positive cells 1 day post‐MI in MRL infarcts compared with C57 infarcts (P= 0.001) and fewer CD45‐positive cells in the MRL infarct border zone 2 days post‐MI (P < 0.01); the LG/J results were intermediate (P= n.s.). The MRL hearts had smaller infarct scars and attenuated ventricular dilatation 30 days post‐MI compared with C57 hearts (P < 0.05). We conclude that the early post‐MI survival advantage of MRL mice over the C57 strain is mediated at least in part by reductions in apoptosis and inflammatory infiltration, and that these reductions may influence chronic remodelling. The intermediate survival, apoptosis and inflammation profile of LG/J mice suggests that this high tolerance for MI in the MRL mouse could be derived from its shared genetic background with the LG/J mouse.
The ROX coupler: Creation of a fixed iliac arteriovenous anastomosis for the treatment of uncontrolled systemic arterial hypertension, exploiting the physical properties of the arterial vasculature

Objectives: Uncontrolled hypertension, whether due to drug resistance or poor adherence and persistence, remains a problem in many patients. The ROX coupler is a novel technology designed to reduce arterial blood pressure consequent to the predicted physical effects of reducing vascular resistance and improving arterial compliance. This article describes the technical aspects of the device and implantation procedure, results from a preclinical study, patient selection criteria, and potential complications of this therapy for uncontrolled hypertension. Background: The coupler is a self‐expanding, stent‐like device that exploits the mechanical effects of the creation of a low‐resistance, high‐compliance venous segment to the central arterial tree, and can be implanted in a standard catheterization laboratory under fluoroscopic guidance. Methods: Preclinical studies were conducted in sheep with acute or chronic hypertension. The devices were implanted in the aorta for up to 12 months. The anastomoses were evaluated for patency, healing, conformation into the artery and vein, and complications. Results: Deployment of the anastomotic device in ovine aortas for up to 12 months showed optimal anastomotic patency in all animals with proper healing and conformation of the device into the artery and the vein. There was no significant residual mural thrombus and minimal to moderate intimal thickening at the vein outflow, consistent with expected arterialization. Conclusions: A novel arteriovenous coupler for percutaneous placement in the iliac vasculature is under clinical investigation as a potential treatment modality for selected patients with uncontrolled hypertension. Initial results from patients with uncontrolled hypertension are expected in Autumn 2014. © 2014 Wiley Periodicals, Inc.
Integrated static and dynamic modeling of an ionic polymer–metal composite actuator

Ionic polymer–metal composites have been widely used as actuators for robotic systems. In this article, we investigate and verify the characteristics of ionic polymer–metal composite actuators experimentally and theoretically. Two analytical models are utilized to analyze the performance of ionic polymer–metal composites: a linear irreversible electro-dynamical model and a dynamic model. We find that the first model accurately predicts the static characteristics of the ionic polymer–metal composite according to the Onsager equations, while the second model is able to reveal the back relaxation characteristics of the ionic polymer–metal composite. We combine the static and dynamic models of the ionic polymer–metal composite and derive the transfer function for the ionic polymer–metal composite’s mechanical response to an electrical signal. A driving signal with a smooth slope and a low frequency is beneficial for the power efficiency.
The participation of reactive oxygen species and protein thiols in the mechanism of mitochondrial inner membrane permeabilization by calcium plus prooxidants.

We have recently shown that permeabilization of the inner mitochondrial membrane by calcium plus prooxidants is associated with oxidation of protein thiols forming cross-linked protein aggregates [Fagian, M. M. , Pereira da Silva, L. , Martins, I. S. and Vercesi, A. E. (1990) J. Biol. Chem. 265, 19955-19960]. In this study we show that mitochondria could regenerate and sustain a membrane potential (delta psi) comparable to the control experiment after the protein aggregates were cleaved by dithiothreitol. The addition of ethylene glycol bis(beta-aminoethyl ether) N,N'-tetraacetic acid, which removes Ca2+ but does not eliminate the protein aggregates, caused an incomplete and nonsustainable recovery of delta psi. Exogenous catalase prevented the disruption of membrane potential and decreased the production of membrane protein aggregates when mitochondria were incubated in the presence of Ca2+ alone or Ca2+ plus a prooxidant. This strongly indicates that H2O2 and possibly other H2O2-derived reactive oxygen species are involved in the mechanism of membrane protein aggregates production that may result in the process of membrane pore formation.
Mohanty Data mining algorithm for manufacturing process control

In this paper, a new data mining algorithm based on the rough sets theory is presented for manufacturing process control. The algorithm extracts useful knowledge from large data sets obtained from manufacturing processes and represents this knowledge using “if/then” decision rules. Application of the data mining algorithm developed in this paper is illustrated with an industrial example of rapid tool making (RTM). RTM is a technology that adopts rapid prototyping (RP) techniques, such as spray forming, and applies them to tool and die making. A detailed discussion on how to control the output of the manufacturing process using the results obtained from the data mining algorithm is also presented. Compared to other data mining methods, such decision trees and neural networks, the advantage of the proposed approach is its accuracy, computational efficiency, and ease of use.
Multifunktionale DNA Kassetten zur konditionalen Mutagenese in der Maus

Im ersten Teil der vorliegenden Arbeit wurden bifunktionale Cre Expressionskonstrukte erzeugt. Diverse Konstruktvarianten exprimieren in ihrer ursprunglichen Form eine Hormon abhangige Fusionsrekombinase, die in vivo durch FLP vermittelte Rekombination auf eine konstitutiv aktive Rekombinaseform umgeschaltet werden kann. Ein weiteres Konstrukt dient in seiner ursprunglichen Form der Expression eines konstitutiv aktiven Fusionsproteins und erlaubt in vivo durch FLP vermittelte Rekombination das Umschalten auf die Expression einer Liganden induzierbaren Fusionsrekombinase. Mit diesem bifunktionalen Konstrukt konnte ein gutes Signal-zu-Rausch Verhaltnis erzielt werden, so dass es zur Herstellung einer transgenen Maus geeignet ist, die eine konstitutiv aktive Rekombinase unter der Kontrolle eines gewebespezifischen Promotors exprimiert. Durch Verpaarung mit einer FLP Rekombinase exprimierenden Maus konnen Nachkommen erhalten werden, die dann eine Liganden induzierbare Fusionsrekombinase gewebespezifisch exprimieren. Der zweite Teil der Arbeit befasst sich mit der Herstellung von DNA Kassetten, die zur konditionalen Inaktivierung von Genen oder zur Reaktivierung zuvor inaktivierter Gene in eukaryotischen Zellen oder in der Maus eingesetzt werden konnen. Die Funktion der generierten induzierbaren NMD Kassetten beruht auf dem Einsatz von Exons, in die Stopcodons in alle drei Leseraster eingefuhrt wurden. Wird eine entsprechende Kassette in Transkriptionsrichtung in ein beliebiges Zielgen inseriert, so wird eines der drei Stopcodons als pramatures Terminationscodon erkannt, wodurch der nonsense mediated mRNA decay Prozess ausgelost wird, der zur Degradierung der mRNA und damit zur Inaktivierung der Genaktivitat fuhrt. Eine konditionale Geninaktivierung wird erzielt, indem die Kassette mit Rekombinase Erkennungssequenzen flankiert wird, die eine Inversion ermoglichen. Dabei kann die Kassette von dem kodogenen in den nicht kodierenden Strang invertiert werden, wodurch die Genaktivitat wiederhergestellt wird.
10 Years of Emergency Endovascular Aneurysm Repair for Ruptured Abdominal Aortoiliac Aneurysms: Lessons Learned

Objective:To evaluate a single center's 10-year experience with emergency endovascular aneurysm repair (eEVAR) in 102 patients with ruptured abdominal aortoiliac aneurysms (RAAA). Methods:Data from 102 patients (mean age, 73 ± 9 years) with RAAA treated by eEVAR from January 1998 to April 2008 were retrospectively reviewed. From January 2000, all patients were treated according to an intention-to-treat protocol. The only exclusion criterion was unsuitable anatomy. 31/102 patients had moderate shock and 14/102 patients had severe shock with a systolic blood pressure <70 mm Hg or <50 mm Hg, respectively. 71/102 procedures were carried out under local anesthesia. Endograft types used were mainly bifurcated (92/102). Open abdomen treatment (OAT) because of abdominal compartment syndrome (ACS) was used when signs of organ failure occurred and/or bladder pressure rose >20 mm Hg. Results:The 30-day mortality for eEVAR was 13% (13/102). Technical success (defined as successful deployment of the endograft, absence of extravasation in the postprocedural contrast enhanced CT scan and hemodynamic stabilization) was 99% (101/102). Nineteen unstable patients (19%) required transfemoral supraceliac aortic balloon occlusion. ACS was detected and treated by OAT in 20 patients (20%). 16 type I, 26 type II and 1 type III endoleaks were detected on postoperative CT examination. Two patients had a combined type I and II endoleak. 11 patients were retreated for immediate correction of 10 type I and 2 type II endoleaks. 6 type I and 1 type III low-flow endoleaks were observed and resolved spontaneously within 30 days. Major 30-day morbidity was 35%. Conclusion:In this 102 patient contemporary series of eEVAR for RAAA, endografting proved to be safe with a 30-day mortality of 13%. Key components of this favorable outcome result were adequate preoperative diagnostic imaging, hypotensive hemostasis, selective transfemoral supraceliac aortic balloon occlusion, predominantly local anesthesia, detection and treatment of ACS, and attention to logistics. Widespread adoption of these treatment components is recommended.
Metal-Ferroelectric-Meta-Oxide-semiconductor field effect transistor with sub-60mV/decade subthreshold swing and internal voltage amplification

This work reports the first complete experimental demonstration and investigation of subthreshold swing, SS, smaller than 60 mV/decade, at room temperature, due to internal voltage amplification in FETs with a Metal-Ferroelectric-Metal-Oxide gate stack. The investigated p-type MOS transistor is a dedicated test structure to explore the negative capacitance effect by probing the internal voltage between the P(VDF-TrFE) and SiO2 dielectric layers of the gate stack. We find that the region of internal surface potential amplification, dψS/dVg>1, corresponds to an S-shape of the polarization versus ferroelectric voltage (associated with negative capacitance). In Fe-FETs the internal voltage amplification could significantly lower their SS, even without reaching sub-60mV/dec values. SSmin as low as 46 to 58 mV/decade and average swings, SSavg, as small as 51 to 59 mV/dec are observed for the first time in a minor loop hysteretic characteristics of Fe-FETs.
Modulation of map kinase signaling and growth characteristics by the overexpression of protein kinase C in NIH3T3 cells

This study was performed to examine effects of the overexpression of protein kinase C (PKC) isoforms (i.e., βI, βII, γ, δ,η, and ζ) mitogen‐activated protein (MAP) kinase (Erk‐1 and ‐2) signaling and growth characteristics of NIH3T3 cells. Phorbol ester (PMA) activated endogenous and ectopically expressed PKCα, βI, βII, γ, δ, ε, and η. Overexpression of the examined PKC isoforms enhanced PMA‐induced MAP kinase activation. Potentiation of MAP kinase activation was also observed upon stimulation of cells with platelet‐derived growth factor (PDGF) although there was no indication for the activation PKC isoforms by PDGF. Inhibition of PKC blocked PMA‐ but not PDGF‐induced MAP kinase activation. Thus, potentiation of PDGF‐induced MAP kinase activation appears to be independent to PKC activity, while PMA‐induced MAP kinase activation requires PKC activity. The ability of PKC isoforms to potentiate MAP kinase activation is not related to the growth characteristics of cells because individual PKC isoforms differentially regulated maximum density and proliferation of cells.
The preparation of arbovirus hemagglutinins by sonication and trypsin treatment.

Abstract For 28 of 31 arboviruses (34 strains) studied, satisfactory hemagglutinins were demonstrated after treatment of sucrose-acetone-extracted liver or brain preparations by either sonication alone or sonication plus trypsin treatment. The methods of antigen treatment are described, and the appearance of a “cellular agglutinin” under some conditions of trypsin treatment is reported. The procedure for hemagglutinin preparation seems to be consistent for any given virus, but variation is seen from virus to virus. Hemagglutination-inhibition testing of selected antigens indicates that sonication alone improves sensitivity, whereas further treatment with trypsin gives variable results.
B Lymphocyte‐Antigen Interactions in the Initiation of Tolerance or Immunity

The dilemma in whicli we find ourselves iii relation to mechanisms of B cell activation illustrates well the limitations of the reductionist approach of conventional laboratory science (Bumet 1969). Any reasonably satisfying intellectual picture needs to encompass at least three problem streams: the entry, transport, trapping, retention and catabolism of antigen (Nossal & Ada 1971); the collaborative phenomena involving T cells, macrophages and B cells which are frequently required for activation (Miller 1972); and the elaborate events of B cell proliferation and differentiation underlying antibody production, immunological memory, germinal centre formation and affinity maturation (Siskind et al. 1966). Furthermore, as we hope to show, activation ciinnot be understood without paying heed to the opposite option confronting the lymphocyte, namely tolerance, and this in turn needs to be seen in the context of B lymphocyte ontogeny (Nossal & Pike 1973, 1975). Nevertheless, and for good reason, most of the debate in the recent literature on B cell activation has focussed on an extremely limited segment of this spectrum, namely the induction of mitogenesis or IgM antibody synthesis in short-term tissue cultures. In fact, it is becoming increasingly fashionable to restrict attention to molecular events occurring during the first minutes or hours of activation. The attractions of the simplified model systems are obvious, and the present paper will refer frequently to them.