Miracle-dz/UniFAR-FTUs huggingface dataset:
Dose–Response Study of Mobilisation and Tactile Stimulation Therapy for the Upper Extremity Early After Stroke

Background. Physical therapy doses may need to be higher than provided in current clinical practice, especially for patients with severe paresis. The authors aimed to find the most effective and feasible dose of Mobilisation and Tactile Stimulation (MTS), which includes joint and soft-tissue mobilization and passive or active-assisted movement to enhance voluntary muscle contraction. Methods. This 2-center, randomized, controlled, observer-blinded feasibility trial compared conventional rehabilitation but no extra therapy (group 1) with conventional therapy plus 1 of 3 daily doses of MTS, up to 30 (group 2), 60 (group 3), or 120 (group 4) minutes for 14 days. The 76 participants had substantial paresis (Motricity Index [MI] < 61) a mean of 30 days (standard deviation [SD] = 20 days) after anterior circulation stroke. MTS was delivered using a standardized schedule of techniques (eg, sensory input, active-assisted movement). The primary outcome was the Motricity Index (MI) and secondary outcome was the Action Research Arm Test (ARAT) tested on day 16. Adverse events were monitored daily. Results. No difference was found in the change in control group MI compared with each of the 3 intervention groups (P = .593) or in the ARAT. Mean actual daily treatment time for all MTS groups was less than expected. The attrition rate was 1.3%. No adverse events related to overuse occurred. Conclusion. The authors were not able to deliver a maximum dose of 120 minutes of daily therapy each day. The mean daily dose of MTS feasible for subsequent evaluation is between 37 and 66 minutes.
Switched Output Feedback Stabilization of Discrete-Time Switched Systems

This paper addresses the problem of switched static output feedback control for a particular class of discrete-time switched systems under arbitrary switching sequences. The considered class of systems is characterized by a particular structure of the control matrices. Our main contribution consists in new sufficient linear matrix inequality (LMI) conditions for the synthesis of a switched controller. The proposed solution uses congruence transformations and is based on the existence of a switched quadratic Lyapunov function that guarantees the asymptotic stability of the closed-loop system. In addition to the numerical tractability of the LMIs, the main advantage of our new conditions resides in the fact that they work successfully for systems for which the existing conditions fail. Our claim is supported by numerical examples that we present in the paper
Physical trauma in epilepsy: Characteristics and implications in a Nigerian adolescent with severe generalized epilepsy

240 Journal of Emergencies, Trauma, and Shock I 8:4 I Oct Dec 2015 the next hour. Urgent angioembolization was performed achieving the closure of the arterial bleeding with coils [Figure 1]. Hemodynamics improved after resuscitation and the patients remained stable in the next days. Repeated CT scan 6 days later showed a significant improvement of the liver hematoma and reabsorption of the juxtacaval hematoma and resolution of the caval compression [Figure 2].
Multinary-Signaling-Based Coded Modulation for Ultrahigh-Speed Optical Transport

A multinary-signaling-based coded-modulation (CM) scheme is proposed, which is suitable for various applications ranging from multi-Tb/s to multi-Pb/s data rates, outperforming conventional CM schemes in terms of both spectral and energy efficiencies. The corresponding multinary signal constellation design algorithm is also proposed. Both 2-D and 3-D multinary-signaling-based CM schemes have been studied.
Animal vision.

No wonder you activities are, reading will be always needed. It is not only to fulfil the duties that you need to finish in deadline time. Reading will encourage your mind and thoughts. Of course, reading will greatly develop your experiences about everything. Reading animal vision is also a way as one of the collective books that gives many advantages. The advantages are not only for you, but for the other peoples with those meaningful benefits.
Momentum Cycles and Limits to Arbitrage Evidence from Victorian England and Post-Depression Us Stock Markets

We evaluate the importance of "Limits to Arbitrage" to explain profitability of momentum strategies. Specifically, when the availability of arbitrage capital is in short supply, momentum cycles last longer, and breaks in momentum cycles are shorter. We demonstrate the robustness of our findings with a unique database of stock returns from1866-1907 London and the CRSP database. Momentum cycle durations are similar in both databases and all other momentum facts documented in the literature using the CRSP database hold for the Victorian period as well, except for the January reversal due to the absence of capital gains taxation.
El microcredito ayuda realmente a los pobres

Ever since microcredit first began to capture public attention 25 years ago, the usual story line has been that it is a tool of extraordinary power to lift poor people-especially women-out of poverty, by funding their microenterprises and raising their incomes. This picture has been buttressed by hundreds of inspiring stories of micro entrepreneurs who used tiny loans to start or expand their businesses, and experienced remarkable gains not only in income and consumption but also in health, education, and social empowerment. But how well do these individual anecdotes represent the general experience of the hundreds of millions who have gotten microloans and other microfinance services? Portfolios shows us that poor households value microfinance because it is very helpful in dealing with their vulnerability, even though the nature of that help may differ substantially from the widespread story line about microloans funding investment in microenterprises that lift their owners out of poverty. But is Portfolios just another set of anecdotes, or does it paint a picture that is generally true for vast numbers of microfinance clients around the world?
Oxysterol-binding Protein Activation at Endoplasmic Reticulum-Golgi Contact Sites Reorganizes Phosphatidylinositol 4-Phosphate Pools*

Oxysterol-binding protein (OSBP) exchanges cholesterol and phosphatidylinositol 4-phosphate (PI-4P) at contact sites between the endoplasmic reticulum (ER) and the trans-Golgi/trans-Golgi network. 25-Hydroxycholesterol (25OH) competitively inhibits this exchange reaction in vitro and causes the constitutive localization of OSBP at the ER/Golgi interface and PI-4P-dependent recruitment of ceramide transfer protein (CERT) for sphingomyelin synthesis. We used PI-4P probes and mass analysis to determine how OSBP controls the availability of PI-4P for this metabolic pathway. Treatment of fibroblasts or Chinese hamster ovary (CHO) cells with 25OH caused a 50–70% reduction in Golgi-associated immunoreactive PI-4P that correlated with Golgi localization of OSBP. In contrast, 25OH caused an OSBP-dependent enrichment in Golgi PI-4P that was detected with a pleckstrin homology domain probe. The cellular mass of phosphatidylinositol monophosphates and Golgi PI-4P measured with an unbiased PI-4P probe (P4M) was unaffected by 25OH and OSBP silencing, indicating that OSBP shifts the distribution of PI-4P upon localization to ER-Golgi contact sites. The PI-4P and sterol binding activities of OSBP were both required for 25OH activation of sphingomyelin synthesis, suggesting that 25OH must be exchanged for PI-4P to be concentrated at contact sites. We propose a model wherein 25OH activation of OSBP promotes the binding and retention of PI-4P at ER-Golgi contact sites. This pool of PI-4P specifically recruits pleckstrin homology domain-containing proteins involved in lipid transfer and metabolism, such as CERT.
Location, location, (ChIP‐)location! Mapping chromatin landscapes one immunoprecipitation at a time

A small fraction of the typical animal genome (<5% in humans) codes for the organism's collection of proteins, yet the study of protein coding sequences dominated the early years of genomics research. In the decade since the sequencing of complete eukaryotic genomes, however, genomic techniques have shed a great deal of light on the non‐coding DNA making up the remainder. A single molecular technique, Chromatin Immuno‐Precipitation (ChIP) location analysis, has had a profound impact and has made possible the study of an incredible range of biology. This issue of The Journal of Cellular Biochemistry aims to put into context advancements made possible by the ChIP‐location revolution, while at the same time highlighting some of the most important technical aspects and challenges along with some of the work yet to come. J. Cell. Biochem. 107: 1–5, 2009. © 2009 Wiley‐Liss, Inc.
Molecular Bacterial Load Assay, a Culture-Free Biomarker for Rapid and Accurate Quantification of Sputum Mycobacterium tuberculosis Bacillary Load during Treatment

ABSTRACT A molecular assay to quantify Mycobacterium tuberculosis is described. In vitro, 98% (n = 96) of sputum samples with a known number of bacilli (107 to 102 bacilli) could be enumerated within 0.5 log10. In comparison to culture, the molecular bacterial load (MBL) assay is unaffected by other microorganisms present in the sample, results are obtained more quickly (within 24 h) and are seldom inhibited (0.7% samples), and the MBL assay critically shows the same biphasic decline as observed longitudinally during treatment. As a biomarker of treatment response, the MBL assay responds rapidly, with a mean decline in bacterial load for 111 subjects of 0.99 log10 (95% confidence interval [95% CI], 0.81 to 1.17) after 3 days of chemotherapy. There was a significant association between the rate of bacterial decline during the same 3 days and bacilli ml−1 sputum at day 0 (linear regression, P = 0.0003) and a 3.62 increased odds ratio of relapse for every 1 log10 increase in pretreatment bacterial load (95% CI, 1.53 to 8.59).
The Role of the Public and Private Sectors in Health Financing in Developing Countries

This paper distinguishes between public health programs and clinical services, and argues that whilst the case for public financing of the former is valid, that for the latter is more questionable. This is partly because of the impossibility any objective definition of an essential clinical package for any country. The use of DALYs (or QALYs) to derive such a package is shown to be conceptually unsound. Equally dubious are the rationales based on "market failure" in health care for public intervention. It is argued there is no a prioi reason to believe that with imperfect information (the major cited source of "market failure") there is any political solution which is "Pareto-superior" to that provided by a competitive market. Nor are the other purported "market failures" unique to health markets. So, as arguments based on an unattainable ideal are considered to be irrelevant in suppressing private markets by political solutions for other goods and services, the same conclusion applies to health markets. As regards the justification for public financing of health care for the poor, it is argued this case is only valid for destitutes, who for reasons of political economy may not do any better from public transfers than from private charity. But such charity might be stimulated by earmarking foreign aid funds for poverty alleviation, on a matching basis, to charities dealing with destitutes. Finally, the paper examines the lessons to be learnt from the private health care market in the United States and the pre-National Health Service private health market in the United Kingdom as contrasted with the experience with socialized medicine. It is argued that the ills of the U.S. health market are due to policy induced distortions in their working. For the "working poor" the mutual aid societies of 19th century Britain are of particular relevance for developing countries, and they too could be encouraged through the provision of matching public funds.
Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance

Adipose tissue (AT) inflammation contributes to impaired insulin action, which is a major cause of type 2 diabetes. RBP4 is an adipocyte- and liver-derived protein with an important role in insulin resistance, metabolic syndrome, and AT inflammation. RBP4 elevation causes AT inflammation by activating innate immunity, which elicits an adaptive immune response. RBP4-overexpressing mice (RBP4-Ox) are insulin resistant and glucose intolerant and have increased AT macrophages and T-helper 1 cells. We show that high-fat diet–fed RBP4−/− mice have reduced AT inflammation and improved insulin sensitivity versus wild type. We also elucidate the mechanism for RBP4-induced macrophage antigen presentation and subsequent T-cell activation. In RBP4-Ox, AT macrophages display enhanced c-Jun N-terminal kinase, extracellular signal–related kinase, and p38 phosphorylation. Inhibition of these pathways and of NF-κB reduces activation of macrophages and CD4 T cells. MyD88 is an adaptor protein involved in proinflammatory signaling. In macrophages from MyD88−/− mice, RBP4 fails to stimulate secretion of tumor necrosis factor, IL-12, and IL-6 and CD4 T-cell activation. In vivo blockade of antigen presentation by treating RBP4-Ox mice with CTLA4-Ig, which blocks costimulation of T cells, is sufficient to reduce AT inflammation and improve insulin resistance. Thus, MyD88 and downstream mitogen-activated protein kinase and NF-κB pathways are necessary for RBP4-induced macrophage antigen presentation and subsequent T-cell activation. Also, blocking antigen presentation with CTLA4-Ig improves RBP4-induced insulin resistance and macrophage-induced T-cell activation.
Low dead time digital SPAD readout architecture for realtime small animal PET

CMOS integrated SPAD array design normally enforces a compromise between circuit functionalities and optical detection fill factor, never quite reaching the ideal detector configuration when both are integrated together on the same substrate. The emergence of vertical 3D integrated circuits (3DIC) changes this restriction and further adds in heterogeneous electronic integration, opening technological combinations otherwise difficult or impractical to obtain. Using this approach, a heterogeneous SPAD array detector prototype with digital readout for small animal PET was developed. It is based on Global Foundries 130 nm CMOS for digital and quenching circuits and on Teledyne Dalsa 0.8 μm HV CMOS process for the SPAD arrays. This paper focuses on the realtime digital architecture tailored for small animal PET scintillation detection, where in addition to tight timing and energy resolution, low PET dead time and high spatial resolution are required. A discriminator circuit is proposed to retain first-photon timing information while protecting against dark count rate triggering. The system provides two operational modes: a slower oscilloscope-like mode and a high rate PET mode providing 2.2M singles per second on a single 200 MHz LVDS transmitter. Performances in terms of electronic jitter and event detection are reported based on simulations.
SEASONALITY IN THE KUWAIT STOCK EXCHANGE

The paper examines seasonally in the Kuwaiti stock market. The purpose of the paper is to determine if a monthly pattern in the return of stock market index exists in Kuwait, and whether such a pattern is similar to the one found in developed stock mar kets. There is ample empirical evidence in the literature for stock market seasonality with a high return in January A widely supported explanation for the "January effect" is the tax-loss selling hypothesis. The paper tries to examines two questions. First, in the absence of taxation, does the January effect exist in the Kuwaiti stock market? Second, if there is a seasonal pattern other than January, what explains such pattern? The empirical results show significant July seasonality, which can be explained by the summer holiday.
Data Mining and Business Analytics with R

Collecting, analyzing, and extracting valuable information from a large amount of data requires easily accessible, robust, computational and analytical tools. Data Mining and Business Analytics with R utilizes the open source software R for the analysis, exploration, and simplification of large high-dimensional data sets. As a result, readers are provided with the needed guidance to model and interpret complicated data and become adept at building powerful models for prediction and classification.
Role of UV in Cutaneous Melanoma †

Malignant melanoma arises from epidermal melanocytes, the cells responsible for the production of the skin pigment melanin. The photoprotective role of melanin, which is transferred to neighboring keratinocytes, in UV‐induced skin carcinogenesis, specifically in nonmelanoma skin cancers, has been well documented. Although melanocyte‐resident melanin is expected to offer similar protection to melanocytes from UV‐induced damage, UV radiation has long been suspected to have an etiologic role in cutaneous melanoma. However, nearly three decades of efforts using a variety of in vitro and in vivo models of human skin and mouse genetic models have produced conflicting data. Epidemiologic studies have also failed to establish a definitive association between UV exposure and risk of melanoma. In this review, we evaluate the dual role of the melanin pigment as a photoprotector as well as a photosensitizer and examine the evidence for association between melanin levels (constitutive and induced) and melanoma risk. We also discuss possible reasons for the lack of signature UV mutations in melanoma oncogenes known to date and potential alternative mechanisms to explain the role of UV in melanomagenesis.
Polymer-based platforms by electric field-assisted techniques for tissue engineering and cancer therapy

A large variety of processes and tools has been investigated to acquire better knowledge on the natural evolution of healthy or pathological tissues in 3D scaffolds to discover new solutions for tissue engineering and cancer therapy. Among them, electrodynamic techniques allow revisiting old scaffold manufacturing approach by utilizing electrostatic forces as the driving force to assemble fibers and/or particles from an electrically charged solution. By carefully selecting materials and processing conditions, they allow to fine control of characteristic shapes and sizes from micro to sub-micrometric scale and incorporate biopolymers/molecules (e.g., proteins, growth factors) for time- and space-controlled release for use in drug delivery and passive/active targeting. This review focuses on current advances to design micro or nanostructured polymer platforms by electrodynamic techniques, to be used as innovative scaffolds for tissue engineering or as 3D models for preclinical in vitro studies of in vivo tumor growth.
Performance Measurement in Healthcare Incentive Plans

By using quantitative survey data and conducting a case study, we examine performance measurement of incentive plans in Finnish private sector health care organizations. We find that the performance measures used in the incentive plans are in line with recent economic theories of performance measurement. The findings from the case study emphasize the importance of choosing appropriate performance measures and designing the pay package as a whole. Inadequate performance measurement leads to incentive plans that do not help organizations reach their goals.
Evaluation of Antihypertensive Effect of Aqueous Methanol Extract of Caralluma tuberculata N.E.Br in Sprauge Dawley Rats

Purpose: To evaluate the phytochemical profile and antihypertensive effect of Caralluma tuberculata N.E. Br (AMECT). Methods: The antihypertensive effect of the aqueous methanol extract of (AMECT) was evaluated in both normotensive and hypertensive rats. In normotensive rats, various doses (100, 300 and 500 mg/kg body weight, p.o.) were administered at 0, 1, 3 and 6 hr intervals. Anti-hypertensive activity of the crude extract was investigated in three experimental hypertensive models, viz, egg-fed diet, glucose-induced and cadmium-induced hypertensive rats. Cardiovascular parameters, including systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP) and heart rate (HR) were measured by tail cuff method using non-invasive blood pressure apparatus (NIBP) attached. AMECT was also investigated for its phytochemical profile. Results: The results indicate that AMECT produced a dose-dependent, significant (p < 0.05) decrease in SBP, DBP, MBP, and HR (p < 0.01) of normotensive rats, when compared to control groups, at all test doses. The 500 mg/kg dose produced a highly significant effect (mm Hg, p < 0.001) in SBP (85.9 ± 7.2), DBP (71.86 ± 12.1), MBP (75.1 ± 11.7) and HR (238.08 ± 8.3 beats/min), in comparison to 100 and 300 mg/kg doses; therefore, 500 mg/kg was selected for antihypertensive test in egg-fed, glucose-induced and cadmium-treated hypertensive rats. Significant (p < 0.05) antihypertensive and negative chronotropic effects were observed in hypertensive models compared to their respective normal controls. Phytochemical analysis revealed the presence of tannins, alkaloids, phenolic compounds, cardiac glycosides and flavonoids. Conclusion : The findings indicate that Caralluma tuberculata possesses significant anti-hypentensive activity in rats. Keywords: Phytochemical profile, Antihypertensive, Cardiovascular, Caralluma tuberculata N.E. Br, Blood pressure
Ottawa Model of Implementation Leadership and Implementation Leadership Scale: mapping concepts for developing and evaluating theory-based leadership interventions

Purpose Leadership in health care is instrumental to creating a supportive organizational environment and positive staff attitudes for implementing evidence-based practices to improve patient care and outcomes. The purpose of this study is to demonstrate the alignment of the Ottawa Model of Implementation Leadership (O-MILe), a theoretical model for developing implementation leadership, with the Implementation Leadership Scale (ILS), an empirically validated tool for measuring implementation leadership. A secondary objective is to describe the methodological process for aligning concepts of a theoretical model with an independently established measurement tool for evaluating theory-based interventions. Methods Modified template analysis was conducted to deductively map items of the ILS onto concepts of the O-MILe. An iterative process was used in which the model and scale developers (n=5) appraised the relevance, conceptual clarity, and fit of each ILS items with the O-MILe concepts through individual feedback and group discussions until consensus was reached. Results All 12 items of the ILS correspond to at least one O-MILe concept, demonstrating compatibility of the ILS as a measurement tool for the O-MILe theoretical constructs. Conclusion The O-MILe provides a theoretical basis for developing implementation leadership, and the ILS is a compatible tool for measuring leadership based on the O-MILe. Used together, the O-MILe and ILS provide an evidence- and theory-based approach for developing and measuring leadership for implementing evidence-based practices in health care. Template analysis offers a convenient approach for determining the compatibility of independently developed evaluation tools to test theoretical models.