Miracle-dz/UniFAR-FTUs huggingface dataset:
Using Domain Knowledge in Classifying Industrial Data from the Oil and Gas Sector

Finding good features for performing supervised learning on high dimensional industrial datasets can be challenging, as your feature set typically consists of hundreds to thousands of features. Specific features might follow protocols or custom coding standards that, unless decoded, are unusable by machine learning algorithms. This is often the case in industrial environments, where you need domain knowledge to interpret the semantics of the data. This paper analyzes the effect of domain knowledge on the supervised learning process in creating classifiers for industrial work orders. Our experiments, using various supervised learning algorithms on a high dimensional real-world dataset, show that incorporating domain knowledge in the pre-processing phase, improves the performance of a classifier substantially. By utilizing domain knowledge we were able to increase the performance of the classifier with 7% measured by Cohen’s Kappa. The two most important features in the resulting model were features extracted using domain knowledge (System and Equipment type). The sum of the importance of the extracted features were 38.97% in the final model. This implies that domain knowledge is crucial in order to avoid erroneous pruning of important encoded features.
Failure of rituximab in human immunodeficiency virus‐associated multicentric Castleman disease

Two human immunodeficiency virus‐infected patients who needed etoposide therapy to control exacerbations of Castleman disease received four infusions of rituximab. Clinical and virologic relapses with increased blood human herpesvirus‐8 DNA levels occurred in both patients 4 and 24 weeks later and were associated with a worsening of Kaposi sarcoma. Am. J. Hematol. 79:337–339, 2005. © 2005 Wiley‐Liss, Inc.
Retail Store Brand Commitment Study of Big Bazaar and Pantaloons

The study is all about the brand commitment by retail stores in the eyes of customers. The extensive literature review done finds the problem that in this competitive environment where the consumer choices fluctuate due to various reasons, it is getting very challenging for stores to maintain the customer’s commitment towards brand at the one end. At the other end to sustain in this war business houses need to hold their customer base, making the customers more loyal. The objectives defined to find the solution for this research problem are to know the level brand commitment of the brands taken in study, to get the comparison of brands commitment and to find the opportunity to expand the brand’s business. A structured questionnaire administered among 550 respondents. The data analyzed using SPSS with t- test and paired t- test. The outcome of paired t- test for the 6 pairs shows that there is no significant difference in opinion of respondents for the variables of brand commitment for both the brands big bazaar and pantaloons.
Chikungunya Protease Domain–High Throughput Virtual Screening

Chikungunya virus (CHICKV) is an arboviruses belonging to family Tagoviridae and is transmitted to human through by mosquito (Aedes aegypti and Aedes albopictus) bite. A large outbreak of chikungunya has been reported in India between 2006 and 2007, along with several other countries from South-East Asia and for the first time in Europe. It was for the first time that the CHICKV outbreak has been reported with mortality from Reunion Island and increased mortality from Asian countries. CHICKV affects all age groups, and currently there are no specific drugs or vaccine to cure the disease. The need of antiviral agents for the treatment of CHICKV infection and the success of virtual screening against many therapeutically valuable targets led us to carry out the structure based drug design against Chikungunya nSP2 protease (PDB: 3TRK). Highthroughput virtual screening of publicly available databases, ZINC12 and BindingDB, has been carried out using the Openeye tools and Schrodinger LLC software packages. Openeye Filter program has been used to filter the database and the filtered outputs were docked using HTVS protocol implemented in GLIDE package of Schrodinger LLC. The top HITS were further used for enriching the similar molecules from the database through vROCS; a shape based screening protocol implemented in Openeye. The approach adopted has provided different scaffolds as HITS against CHICKV protease. Three scaffolds: Indole, Pyrazole and Sulphone derivatives were selected based on the docking score and synthetic feasibility. Derivatives of Pyrazole were synthesized and submitted for antiviral screening against CHICKV. Keywords—Chikungunya, nsP2 protease, ADME filter, HTVS, Docking, Active site.
Immunological and Physiological Differences Between Layer- and Broiler Chickens after Concurrent Intratracheal Administration of Lipopolysaccharide and Human Serum Albumin

Layers and broilers were concurrently intratracheally challenged with 0.5 mg Lipopolysaccharide (LPS) and 0.1 mg Human Serum Albumin (HuSA) at 3 weeks of age. Specific total and isotype-specific (IgM, IgG, IgA) Antibody (Ab) responses to HuSA during 3 weeks following immunization, cellular in vitro mitogen responses to Concanavalin A (Con A) and specific cellular responses in vitro to different dosages of HuSA, blood serotonin (5-HT) levels, plasma Corticosterone (CORT) levels at 6 weeks of age and ex vivo nitric oxide (NO) production in the presence of LPS, respectively, were measured in all birds. Higher in vitro cellular responses to HuSA, but not Con A, were found in the broilers than in the layers. Also higher total, IgM and IgG antibody responses to HuSA were found in the broilers. Higher ex vivo NO production was found in the layers. A heavier spleen weight was found in the broilers, but relative spleen weight was higher in the layers. The broilers grew much heavier and also maintained a higher growth during the first 24 and 48 h after i.t. challenge with LPS and HuSA. No breed effect was found for body temperature responses after i.t. challenge. Blood 5-HT levels and plasma CORT levels were significantly higher in the layers. Number and type of significant correlations between 5-HT levels, cachectin response to LPS, antibody levels and cellular immunity differed between breeds. Our data suggest comparable immune responses to i.t. HuSA challenge in broilers and layers of similar age and confirm the earlier reported higher humoral immune response in broilers. On the other hand, the cachectin response to LPS differed between broilers and layers. Our results do not confirm the earlier reported higher cellular immune response of layers. Different significant relationships between physiological parameters in broilers and layers were found. Our results suggest that selection for enhanced growth does not necessarily affect specific immune competence of poultry.
Comparable potency of IFNα2 and IFNβ on immediate JAK/STAT activation but differential down-regulation of IFNAR2

Type I IFNs (interferons) (IFNα/β) form a family of related cytokines that control a variety of cellular functions through binding to a receptor composed of IFNAR (IFNα receptor subunit) 1 and 2. Among type I IFNs, the α2 and β subtypes exhibit a large difference in their binding affinities to IFNAR1, and it was suggested that high concentrations of IFNAR1 may compensate for its low intrinsic binding affinity for IFNα2. We tested whether receptor-proximal signalling events are sensitive to IFNAR1 surface concentration by investigating the relationship between relative IFNAR1/IFNAR2 surface levels and IFNα2 and IFNβ signalling potencies in several cell lines. For this, we monitored the activation profile of JAK (Janus kinase)/STAT (signal transducer and activator of transcription) proteins, measured basal and ligand-induced surface decay of each receptor subunit and tested the effect of variable IFNAR1 levels on IFNα2 signalling potency. Our data show that the cell-surface IFNAR1 level is indeed a limiting factor for assembly of the functional complex, but an increased concentration of it does not translate into an IFNα/β differential JAK/STAT signalling nor does it change the dynamics of the engaged receptor. Importantly, however, our data highlight a differential effect upon routing of IFNAR2. Following binding of IFNα2, IFNAR2 is internalized, but, instead of being routed towards degradation as it is when complexed to IFNβ, it recycles back to the cell surface. These observations suggest strongly that the stability and the intracellular lifetime of the ternary complex account for the differential control of IFNAR2. Moreover, the present study opens up the attractive possibility that endosomal-initiated signalling may contribute to IFNα/β differential bioactivities.
Aplicación de estándares de e-learning para la integración de videojuegos educativos en el flujo de la enseñanza

Este trabajo de tesis propone facilitar la integracion efectiva de los videojuegos educativos en el flujo de la ensenanza para permitir la participacion de los educadores en este proceso. Con este proposito, en primer lugar se propone un modelo conceptual para la integracion que sirva a los educadores como apoyo y orientacion en este proceso. El modelo conceptual esta formado (1) por un modelo general que propone como aprovechar los estandares de interoperabilidad actuales en la integracion de juegos; y (2) por una metodologia de trabajo que recoge las pautas necesarias para maximizar el potencial evaluativo y adaptativo de los juegos en combinacion con otras actividades educativas. A continuacion, se propone una arquitectura tecnologica que permite al educador aplicar las ideas del modelo conceptual en el mundo real. Esta arquitectura que denominamos middleware (porque media entre el EVA y el nucleo del juego) abstrae los detalles tecnicos de los dos frentes identificados del problema, el juego y el EVA. De esta forma la configuracion de la evaluacion y adaptacion en el juego es resistente a cambios en el EVA en el que finalmente se despliega. La arquitectura se ha implementado en la plataforma de autoria de juegos educativos eAdventure, de forma que los juegos desarrollados en esta plataforma pueden ser exportados para su despliegue en distintos EVAs, bien sea de manera estandarizada o de manera ad hoc en aquellos EVAs que no proporcionen soporte a estandares. Este es el caso de LAMS, un EVA inspirado en IMS Learning Design que permite al educador organizar el aprendizaje en torno a secuencias de actividades que pueden ser complejas y contener ramificaciones, pero que no cumplen ningun estandar de e-learning. Para concluir este trabajo, se ha desarrollado una herramienta especifica para la integracion de juegos eAdventure en LAMS, de tal manera que los juegos puedan utilizarse para crear ramificaciones en las secuencias, lo que sirve para evaluar las ideas reflejadas en el modelo conceptual sobre la adaptacion de las secuencias de aprendizaje. Por ultimo, se ha llevado a cabo una serie de casos de estudio para evaluar el modelo conceptual y las herramientas de apoyo propuestas, con el objetivo de validar su potencial educativo, la aplicabilidad en el entorno real y la aceptacion por parte de los educadores
Percutaneous Radiofrequency Ablation and Endoscopic Esophageal Stenting for Undifferentiated Thyroid Cancer

We report a 69-year-old woman who received chemotherapy and radiation for thyroid tumor (undifferentiated cancer) after surgery in 1998. Chemotherapy was regularly repeated in order to avoid relapse. However, the tumor increased gradually, eventually causing dysphagia. Although we offered nutritional management through intravenous hyperalimentation or gastrostomy, she strongly preferred the oral intake of nutrition. Therefore, after obtaining her consent, we performed percutaneous radiofrequency ablation (RFA) for the tumor using a Cool-Tip needle, on April 2, 2003. The algorithm of RFA was 9min: 30 120 W, 12min: 50 110 W, 9min: 50 100 W. After 2 days, a covered stent was implanted to the esophagus, and oral intake was started. Although the operation for poorly differentiated thyroid cancer is controversial, we performed RFA and esophageal stenting to improve the patient’s QOL. We believe this is the first such case in the world.
Data privacy: An end-user perspective

Online privacy has become a raising concern for digital citizens within the past few years. As users of the Internet, we are in an uncomfortable situation regarding the protection of our online data. We share, tweet, like and follow at an ever-increasing rate, while at the same time getting more aware of the possible dangers of privacy breach or identity theft. Is it possible to navigate on the web while being sure we’re not being spied on? This paper highlights the main data collection fields, taking a user’s view on the risks and tradeoffs regarding online data collection and privacy.
Exploring the Determinants of E-Service Quality in E-Retailing

The expeditious development of technology and the internet has diverted the company direction to retain customer satisfaction by providing superior service quality. It is becoming an area of great interest for companies and it has a straight impact on the profitability of a company. With regard to client service quality significance, we investigate the determinants of service quality which affects customers. Measurement and improvement of electronic service quality is important for keeping competitive advantage of an e-retail site. If online retailers understand what dimensions customers use to evaluate quality, they can take appropriate actions to monitor and enhance performance on those dimensions and remedy service failures. This paper focuses on investigating the effective factors in successful electronic retailing. In order to test the factors a questionnaire survey was designed and questionnaires were sent to online customers of e-retailing; the sample consisted of 452 respondents. By applying exploratory factor analysis and structural equation model we found that responsiveness, security, reliability, Website design, ease of use and personalization are the six leading factors which affects consumer opinion of e-retailing.
REVIEWING THE ROLE OF MUSIC IN THE MANAGEMENT OF AGITATION IN PEOPLE WITH ALZHEIMER'S DISEASE: CAN IT BE ADDED TO THE OCCUPATIONAL THERAPY TOOLKIT?

Purpose: This review explores the current use of music in the management of agitated behavioural symptoms of Alzheimer’s disease (AD) and dementia, the effects of music on these symptoms and the potential therapeutic use of music in the context of occupational therapy. Methods: A literature search was conducted using the keywords ‘Alzheimer’s disease’, ‘dementia’, ‘agitation’, ‘behavioural symptoms’, ‘music’ and ‘music therapy’. Databases searched were: Medline, CINAHL, Ovid, OTDBase, OT Seeker, PsychINFO and Cochrane Database of Systematic Reviews. Secondary sources were identified using a forward search from key articles. For inclusion, articles needed to be published in English and peer reviewed. Articles were restricted to those exploring music and/or music therapy for management of agitated behaviours in AD or dementia and have clinical relevance to occupational therapy. Databases were searched for articles between January 1990 and June 2010. Results: 32 articles were identified in the primary search. A total of 16 research based articles met criteria and are included in the review. One research article was published by an occupational therapist (Casby & Holm, 1994). In addition, eight literature reviews and one Cochrane review were identified. Publications excluded from this review included: two articles not available in English; seven articles exploring topics not relevant to the review; one article due to uncertainty if participants had dementia; and three articles not targeting agitation as an outcome of the intervention. Multiple authors have found substantial improvements in behavioural symptoms of dementia using musical interventions, although many of these studies have methodological limitations. Conclusions: Despite sufficient evidence to warrant the use of music as a creative, individualised and non-pharmacological strategy for the management of behavioural symptoms of AD, to date there is little documented evidence on the use of music by occupational therapists working in dementia care. The potential for music to improve participation and function in daily life, reduce caregiver stress and enhance wellbeing suggest music could substantially add to the occupational therapists tool kit.
EIN MODELL ZUR BERECHNUNG OPTIMAL KOORDINIERTER LICHTSIGNALSTEUERUNGEN

DAS IN DER VORLIEGENDEN UNTERSUCHUNG ENTWICKELTE OPTIMIERUNGSMODELL BIETET DIE MOEGLICHKEIT ZU EINEM VERGLEICHSWEISE WENIG AUFWENDIGEN EINSATZ EINES NUMERISCHEN PLANUNGSVERFAHRENS FUER DEN SIGNALPROGRAMMENTWURF. ES ZEICHNET SICH DURCH FOLGENDE MERKMALE AUS: SEHR EINFACHE DATENEINGABE - KEINE BESCHRAENKUNG DES BEHANDELBAREN VERKEHRSNETZES - BEWUSST APPROXIMATIVES, ABER IN WESENTLICHEN PUNKTEN REALISTISCHES VERKEHRSFLUSSMODELL - SCHNELLE BERECHENBARKEIT DER ZIELGROESSEN FUER DIE OPTIMIERUNG. DER VERFASSER HAT UNTER BENUTZUNG DER TATSACHE, DASS DIE ZIELFUNKTION DIFFERENZIERBAR IST, EIN GRADIENTEN-RUNDUNGS-VERFAHREN ENTWICKELT, DAS AUF DEM WEG EINES "QUASI STEILSTEN ABSTIEGES" EINE LOKALE LOESUNG DES PROBLEMS FINDET. DIESES OPTIMIERUNGSVERFAHREN IST DER "HILL-CLIMBING" PROCEDUR VON TRANSYT VERWANDT, HAT JEDOCH DEN VORTEIL, DASS ES UNABHAENGIG VON IRGENDEINER NUMERIERUNG DER KNOTENPUNKTE IST, AUSSERDEM IM LAUFE DER OPTIMIERUNGSRECHNUNGEN SCHNELLER ZU BESSEREN LOESUNGEN DURCH GLEICHZEITIGES VERSETZEN MEHRERER KNOTENSIGNALPROGRAMME GELANGT. DIE ANWENDUNG DES BESCHRIEBENEN OPTIMIERUNGSMODELLS UND DAS PROGRAMM PROSIG WIRD EINEM KLEINEREN UND ABGEGRENZTEN VERKEHRSNETZ IN EINEM HAMBURG-ELBVORORT GEZEIGT.
A multicenter study of the effect of solution temperature on nasal potential difference measurements.

BACKGROUND Nasal potential difference (PD) measurement quantifies the abnormal sodium and chloride transport that is characteristic of cystic fibrosis (CF) and has gained acceptance as both a diagnostic tool and outcome measure for new CF therapies. Because small changes in nasal PD-measured chloride transport are often an important component in evaluating new CF therapies, techniques to maximize sensitivity and reproducibility are essential. STUDY OBJECTIVE To determine if administration of warmed nasal PD solutions (37 degrees C), instead of room temperature solutions (22 degrees C), results in significant increase in nasal PD-measured transepithelial chloride transport. DESIGN Multicenter, prospective, cross-over trial of repeated measurements of nasal PD at 22 degrees C and 37 degrees C. RESULTS Thirty-two healthy volunteers completed the study (four centers, each with 8 subjects). For 22 degrees C vs 37 degrees C, baseline (+/- SD) nasal PD (- 19.3 +/- 6.9 millivolts [mV] vs - 18.8 +/- 7.7 mV, p = 0.76), amiloride-sensitive PD (Delta PD, 10.4 +/- 5.6 mV vs 11.0 +/- 6.1 mV, p = 0.60), and low chloride response (Delta PD, - 10.0 +/- 8.0 mV vs - 8.0 +/- 7.1 mV, p = 0.13) were not statistically significantly affected by warming of solutions. Warming solutions to 37 degrees C dramatically increased the chloride transport response to isoproterenol (Delta PD, - 6.9 +/- 6.4 mV vs - 13.3 +/- 8.8 mV, p < 0.01) and the combined total response to low chloride and isoproterenol (Delta PD, - 16.9 +/- 9.5 mV vs - 21.3 +/- 11.9 mV, p = 0.01). The average increases observed with warming in isoproterenol and combined total responses were - 6.4 mV (95% confidence interval [CI], - 8.5 to - 4.3) and - 4.4 mV (95% CI, - 7.6 to - 1.1), respectively. CONCLUSIONS Performing nasal PD studies with solutions at 37 degrees C instead of 22 degrees C increases the observed total chloride response by approximately 25% and the isoproterenol-dependent chloride response by approximately 95%. The Cystic Fibrosis Foundation Therapeutics Development Network now recommends warming of solutions as a standard procedure for nasal PD protocols. Utilization of warmed solutions will standardize nasal PD techniques across centers and potentially increase the ability to identify therapies that result in small incremental improvements in CF transmembrane conductance regulator function.
A fluorescence-based opsonophagocytosis assay to measure the functional activity of antibody to group B Streptococcus

An in vitro assay designed to measure the functional activity of vaccine-induced antibody is a necessary component of any vaccine development program. Because traditional efficacy studies of vaccines to prevent neonatal diseases caused by group B Streptococcus (GBS) are unlikely given the effectiveness of current antibiotics and screen-based surveillance practices, the ability to efficiently and effectively measure functional antibody responses may be of particular importance. GBS, like other encapsulated bacterial pathogens, are susceptible to opsonization by specific antibody and complement and subsequent killing by the host’s effector cells. The in vitro opsonophagocytosis and killing assay (OPA) mimics this in vivo defense strategy and has been used for decades to measure the functionality of natural and/or vaccine-induced GBS-specific antibody. Here we describe a fluorescence-based OPA (flOPA) that measures the ability of specific antibody to opsonize fixed, fluorescently labeled GBS or antigen-coated fluorescent microspheres for uptake by differentiated HL-60 cells in the presence of complement. Compared to the classical OPA, the flOPA is standardized with respect to effector cells, complement, and antigenic targets. The GBS flOPA is also less time-intensive and has the potential to measure antibody to multiple antigens simultaneously. Quantitative functional antibody determinations using the flOPA may serve as a surrogate measure of GBS vaccine effectiveness in lieu of traditional phase 3 efficacy trials.
Above all 'do no harm'. How shall we avoid errors in medicine?

The classic approach to quality of care evaluation has included an examination of structure, process, and outcomes and the relationship between these fundamental components of patient care. The articles by Bates et al 1 and Leape et al 2 in this issue of JAMA make an important contribution to quality-of-care evaluation by studying errors in medicine. They provide a conceptual framework, a clear and useful data analysis, and a systems analysis each of which contributes to our understanding of how care might be improved. By focusing on hospital-based adverse drug events (as errors in medicine), these researchers have shown that errors in care are prevalent and often preventable. They have shown that the systematic study of errors is feasible even when it relies on practicing physicians and on nurses as the informants of the errors. They have developed a taxonomy for adverse drug events that is clinically based. They make
Bioproduction of Therapeutic Proteins in the 21st Century and the Role of Plants and Plant Cells as Production Platforms

Abstract: In the last decade, the technique to genetically modify crop plants has gained more and more interest in terms of bioproduction of heterologous proteins. Plants have been discovered as a possible source for large amounts of cost effective recombinant protein. Main application fields are therapeutics for use in animal and human health, diagnostics, and technical enzymes. This review is focused on the recent progress in this field of molecular farming. After a comparison with hitherto established protein production systems, the advantages of plants as an alternative production system are discussed. An overview about the different host plants and possible expression strategies is given and the progress in commercialization of the techniques is highlighted. Finally, the role of plant cell cultures for the production of recombinant proteins is discussed.