Miracle-dz/UniFAR-FTUs huggingface dataset:
Drugs for the Treatment of Chronic Hand Eczema: Successes and Key Challenges

Abstract Chronic hand eczema (CHE) is a common and burdensome inflammatory skin condition seen in up to 10% of the population, more often in high-risk occupational workers. Topical therapeutics comprise the standard of care, but up to 65% of cases do not resolve after treatment, and moderate-to-severe cases are often resistant to topical therapeutics and require systemic options instead. To date, there are no systemic therapeutics approved to treat CHE in the United States, but several drugs are under investigation as potential treatments for CHE. The primary focus of this review is on the novel therapeutics, topical and systemic, that are under investigation in recently completed or currently ongoing trials. This review also briefly outlines the existing treatments utilized for CHE, often with limited success or extensive adverse effects. CHE represents a major challenge for physicians and patients alike, and efforts to improve the minimally invasive diagnostic tools and treatment paradigms are ongoing. In the near future, CHE patients may benefit from new topical and systemic therapeutics that specifically target abnormally expressed immune markers.
Perfil sintáctico de niños con y sin Trastornos del Desarrollo del Lenguaje: Un análisis descriptivo

Studies in children with Developmental Language Impairment (DLI known before as Specific Language Impairment) have isolated anomalies affecting varying elements in the grammar of different languages. The importance of these descriptions is that allows a better understanding of the DLI and the linguistic phenomenon. In this framework, the aim of this study was to describe the grammatical deviations in Spanish speaking children with DLI. To achieve this, texts were analyzed from the NIR2004 corpus of 38 children with DLI and 38 children with Typical Development Language (TDL), aged between 5 and 5 years and 11 months, attending preschool. Texts analyses were focused on detecting and classifying grammatical deviations: disagreement, elision, substitution, word disorder, overregularization and addition. Results show that both DLI and TDL children present these grammatical deviations, but the amount of deviations performed by the DLI children is significantly higher for the first five types. These results allowed to initially verify the description of the grammatical features of the DLI as a higher rate of errors, consistent with Leonard’s (2014) proposal.
Chemical structure study of SiO2/4H-SiC (0001) interface transition region by angle-dependent x-ray photoelectron spectroscopy

The chemical structure of SiO2/4H-SiC (0001) interface transition region is investigated using angle-dependent x-ray photoelectron spectroscopy. The relative intensities of various silicon oxycarbides (SiOxCy) components as a function of polar emission angle suggest that SiOC3, SiO2C2, SiO3C, and SiO2 have different depth distributions at the interface. Then a nonabrupt four-layer structure model is proposed. And the relative intensities of various SiOxCy species are fitted based on the model by an electron damping scheme. The well fitted results indicate that the SiO2/4H-SiC (0001) interface transition region can be described by a chemically nonabrupt four-layer structure model well.
Biofabricated 3D in vitro model of fibrosis‐induced abnormal hepatoblast/biliary progenitors' expansion of the developing liver

Abstract Congenital disorders of the biliary tract are the primary reason for pediatric liver failure and ultimately for pediatric liver transplant needs. Not all causes of these disorders are well understood, but it is known that liver fibrosis occurs in many of those afflicted. The goal of this study is to develop a simple yet robust model that recapitulates physico‐mechanical and cellular aspects of fibrosis mediated via hepatic stellate cells (HSCs) and their effects on biliary progenitor cells. Liver organoids were fabricated by embedding various HSCs, with distinctive abilities to generate mild to severe fibrotic environments, together with undifferentiated liver progenitor cell line, HepaRG, within a collagen I hydrogel. The fibrotic state of each organoid was characterized by examination of extracellular matrix (ECM) remodeling through quantitative image analysis, rheometry, and qPCR. In tandem, the phenotype of the liver progenitor cell and cluster formation was assessed through histology. Activated HSCs (aHSCs) created a more severe fibrotic state, exemplified by a more highly contracted and rigid ECM, as well higher relative expression of TGF‐β, TIMP‐1, LOXL2, and COL1A2 as compared to immortalized HSCs (LX‐2). Within the more severe fibrotic environment, generated by the aHSCs, higher Notch signaling was associated with an expansion of CK19+ cells as well as the formation of larger, more densely populated cell biliary like‐clusters as compared to mild and non‐fibrotic controls. The expansion of CK19+ cells, coupled with a severely fibrotic environment, are phenomena found within patients suffering from a variety of congenital liver disorders of the biliary tract. Thus, the model presented here can be utilized as a novel in vitro testing platform to test drugs and identify new targets that could benefit pediatric patients that suffer from the biliary dysgenesis associated with a multitude of congenital liver diseases.
Comparing particulate matter dispersion in Thailand using the Bayesian Confidence Intervals for ratio of coefficients of variation

Abstract Recently, harmful levels of air pollution have been detected in many provinces of Thailand. Particulate matter (PM) contains microscopic solids or liquid droplets that are so small that they can be inhaled and cause serious health problems. A high dispersion of PM is measured by a coefficient of variation of log-normal distribution. Since the log-normal distribution is often used to analyse environmental data such as hazardous dust particle levels and daily rainfall data. These data focus the statistical inference on the coefficient of variation. In this paper, we develop confidence interval estimation for the ratio of coefficients of variation of two log-normal distributions constructed using the Bayesian approach. These confidence intervals were then compared with the existing approaches: method of variance estimates recovery (MOVER), modified MOVER, and approximate fiducial approaches using their coverage probabilities and average lengths via Monte Carlo simulation. The simulation results show that the Bayesian confidence interval performed better than the others in terms of coverage probability and average length. The proposed approach and the existing approaches are illustrated using examples from data set PM10 level and PM2.5 level in the northern Thailand.
Revisiting Late-Onset Asthma: Clinical Characteristics and Association with Allergy

Abstract The Global Initiative for Asthma (GINA) 2020 defines late-onset asthma (LOA) as one of the clinical phenotypes of asthma wherein patients, particularly women, present with asthma for the first time in adult life, tend to be non-allergic and often require higher doses of inhaled corticosteroids (ICS) or are relatively refractory to corticosteroid treatment. In this review, we examine the published literature improve the understanding of the following aspects of LOA: 1) the age cut-off for its diagnosis; 2) its distinct clinical phenotypes, characteristics and risk factors; and 3) its association with allergic comorbidities and conditions. Overall, our review reveals that clinicians and researchers have used multiple age cut-offs to define LOA, with cut-off ages ranging from >12 years to ≥65 years. LOA has also been classified into several distinct phenotypes, some of which drastically differ in their clinical characteristics, course and prognosis. Although LOA has traditionally been considered non-allergic in nature, our review indicates that it is commonly associated with allergic features and comorbidities. Our findings suggest that there is an urgent need for the development of more clear clinical practice guidelines that can provide more clarity on the definition and other aspects of LOA. In addition, the association of LOA and allergy needs to be re-examined to frame a more optimal treatment strategy for patients with LOA.
An update on the dietary ligands of the AhR

Background: Halogenated aromatic hydrocarbons including dioxins and non-halogenated polycyclic aromatic hydrocarbons are ligands of an aryl hydrocarbon receptor (AhR) and stimulate its transformation. Exposure to these environmental contaminants occurs mainly through diet. Recent articles demonstrated that certain food factors regulate the AhR transformation and expression of downstream drug-metabolizing enzymes. Objective: To explain the actions of these food factors on the AhR transformation, as the mechanisms underlying are not fully understood. Methods: This review introduces recent articles that have demonstrated the molecular mechanisms by which food factors regulate the AhR transformation and downstream drug-metabolizing enzymes. Results/conclusion: The role of classical ligands including dioxins as agonists of the receptor is well documented. As to the food factors, they act as antagonists because they basically suppress the AhR transformation by different mechanisms. Moreover, the fate and metabolism of food factors are important to understand their mechanisms.
Perancangan Media Pembelajaran Tematik Sekolah Dasar Berbasis Serious Game

Pembelajaran tematik merupakan pembelajaran terpadu yang menggunakan tema sebagai pokok pikiran atau gagasan pokok pembicaraan dengan mengaitkan beberapa mata pelajaran, sehingga dapat memberikan pengalaman bermakna kepada siswa. Transfer pembelajaran berbasis tematik ke siswa Sekolah Dasar tidak mengalami kesulitan bagi guru jika dilakukan secara langsung di sekolah. Akan tetapi, pandemi covid-19 pada saat ini menyebabkan digunakannya media pembelajaran online sehingga guru-guru mengalami kesulitan. Kesulitan penyampaian materi tersebut juga dirasakan orang tua yang juga berusaha memberikan pembelajaran berbasis tematik di rumah berdasarkan buku yang diperoleh dari sekolah. Penelitian ini merancang framework pembelajaran berbasis serious game berdasarkan buku tematik Sekolah Dasar dengan tujuan dapat mempermudah guru dalam melakukan pembelajaran jarak jauh serta mempermudah orang tua dalam menyampaikan materi yang terdapat di dalam buku tematik tingkat Sekolah Dasar. Hasil penelitian menunjukkan bahwa komponen utama dalam perancangan serious game untuk memenuhi komponen pedagogi dan fun adalah game component, graph design, database design dan fitur design, di mana konsep immersifitas merupakan hal pokok sebagai upaya yang dapat membuat pemain masuk ke dalam suasana permainan dan mendapatkan pengalaman lebih dari permainan tersebut.
Effects of Economic Growth on the Environment in the Congo: The Case of Air Pollution.

The purpose of this study is to examine the effects of economic growth on the environment in the Republic of Congo. The analysis was based on the validity of the Kuznets environmental curve. For this purpose, the Johansen co-integration test (1988) and the VECM model were used over the period 1971-2014. The results of the study show that there is a long-term relationship between CO2 emissions and GDP. This last relationship suggests that in the long run, there is a Kuznets environmental curve in the Republic of Congo.
Novel framework for investment prioritisation based on flexibility needs assessment

: This study presents a novel framework for investment prioritisation in a distribution network by performing a flexibility needs assessment with regards to power quality parameters. Power range and time instances of activation are identified with a view of maintaining normal operation. A step forward is made by incorporating the importance of the flexibility needs assessment in investment prioritisation as part of the network expansion planning. The proposed framework consists of three procedures: input data preparation, operational calculations and the post-processing of results, which are used to quantify the flexibility needs and propose an investment prioritisation list. A bus node, which forms a part of the existing distribution network in Slovenia, is used to demonstrate the general applicability of the framework. As a result, an investment prioritisation list was compiled by assessing the flexibility needs. The secure power supply buffer of the node is determined, while the quantification of the flexibility power range and time instances of activation are also provided in order to further mitigate network constraints. Apart from providing valuable information to network operators, the newly proposed framework lays the foundation for aggregators and market players to plan and self-balance their portfolio and position when providing flexibility market services.
Bandwidth Improvement of Conventional Dual-Band Power Divider Using Physical Port Separation Structure

This paper presents the bandwidth improvement for dual-band power divider using complex isolation network while maintaining physical port separation. The conventional port-extended power dividers suffered from narrow system bandwidth. A rigorous analysis revealed that such problem was mainly due to the limited impedance bandwidth caused by the odd-mode bisected network. Moreover, the isolation bandwidth provided by the parallel L-C topology in the conventional approach was also limited. To overcome such technical issues, a serial L-C topology was proposed. Derivations of the impedance bandwidth through even- and odd-mode network analysis have been performed and optimal system bandwidth could be achieved when the reflection coefficients of the corresponding bisected networks exhibited minimum frequency dependence. Based on the theoretical analysis, simultaneous achievement of bandwidth broadening, size compactness, and physical port extension at both frequencies is possible with optimum combinations of the design parameters. The experimental results evidenced that other than the improvement in system bandwidth, the fabricated prototype featured low extra insertion loss, good isolation across the bands, and compactness in size while maintaining physical separation between the split ports compared with previously published works.
Proficient operation of grid interfaced solar PV system for power quality improvement during adverse grid conditions

The penetration of solar energy into the distribution network is affected by the seasonal and day-to-day variability of the solar power generation. In underdeveloped and developing countries, the power quality (PQ) deterioration issues are primarily observed due to the presence of the weak utility grid. Therefore, smart grid operability is achieved through power exchange along with the improvement in PQ indices by the application of the biquad filter, thereby exhibiting multifunctional control capability. The biquad filter is less affected by quantization errors and involves no additional usage of sensors or control loops, which are the significant advantages observed in its implementation. The biquad filter utilization in this work, includes the estimation of fundamental load current along with mitigation of harmonics, improving PQ, reactive power compensation, and satisfactory performance during voltage unbalance, sag, distortion, swell, and unbalanced loading conditions, which are observed during weak grid conditions. The stochastic inputs of the solar PV array interfaced utility grid system are agitated due to the erratic availability of solar power, and are overcome through an adaptive perturb and observe technique, which uses a variable perturbation step size. Test cases considered here, validate the performance in accordance to the IEEE-519 standard.
Analisis Peramalan dengan Metode Time Series Pada Produk Hair Dryer

Peramalan adalah metode yang digunakan untuk memperkirakan dan meramalakan suatu nilai atau kejadian dimasa depan dengan menggunakan data masa lalu. Peramalan ini menggunakan produk hair dryer yang dilakukan di daerah Medan, Sumatera Utara. Penelitian ini membahas mengenai analisis peramalan produk hair dryer. Peramalan yang dilakukan mengggunakan metode yaitu metode time series yang digunakan untuk. mengetahui tingkat kesalahan (error) dari variabel mana yang terkecil, maka metode peramalan yang terpilih yaitu metode Linear dan Konstan. Time series adalah metode yang digunakan untuk menganalisis serangkaian data yang merupakan fungsi dari waktu.Peramalan dilakukan untuk mengetahui data di masa mendatang. Metode time series menggunakan 2 variabel yaitu PDRB Lapangan Usaha ADHB 2000 (Juta Rupiah) dan Inflasi (Umum) Tahunan Tahun 2009 – 2018. Berdasarkan pengumpulan dan pengolahan data serta analisa yang sudah dilakukan maka dapat kita bandingkan bahwa dari segi tingkat kesalahan serta perangkingan trend analysis maka MAPE mempunyai tingkat kesalahan yang lebih kecil dibandingkan dengan metode SEE. Metode trend analysis mempunyai nilai MAPE sebesar 0,227 dan SEE sebesar 1563656835413320. Dapat disimpulkan bahwa metode terpilih adalah metode linier, dengan error MAPE. Berdasarkan analisa penetuan peramalan jumlah penjualan produk hair Tahun 2019 Y’ = 25503768,18 dan Tahun 2020 Y’ = 25503768,18. Forecasting is a method used to estimate and forecast a value or event in the future by using past data. This forecasting uses a hair dryer product which is carried out in Medan, North Sumatra. In this research, we discuss the analysis of forecasting hair dryer products. Forecasting is done using the method that is the time series method used for. compare the smallest error rate, then the chosen forecasting method is the Linear and Constant method. Time series is a method used to analyze a series of data that is a function of time. Forecasting is done to find out data in the future. The time series method uses 2 variables namely PDRB Field of Business ADHB 2000 (Million Rupiah) and Annual (General) Inflation in 2009 - 2018. Based on data collection and processing and analysis that has been done, we can compare that in terms of error rates and trend analysis ranking then MAPE has a smaller error rate compared to the SEE method. The trend analysis method has a MAPE value of 0.227 and a SEE of 1563656835413320. It can be concluded that the chosen method is the linier method, with MAPE error. Based on the analysis of forecasting the number of sales of hair products in 2019 Y '= 25503768.18 and 2020 Y' = 25503768.18.
Synthesis of α-ribonucleoside (Majority) by the Coupling of NP/KI and NP/I₂

In this work we will demonstrate a method of preparing α-D-ribonucleosides using the solid-phase approach using the combination between natural phosphate doped with potassium iodide (NP/KI) and natural phosphate doped with iodine (NP/I2). All these derivatives ribonucleosides were prepared by N-glycosylation reaction between silylated bases and 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranoside.
Alocação Ótima De Geradores Distribuídos Para Redução De Perdas Em Sistemas Elétricos De Distribuição Considerando Incertezas Da Demanda

This paper presents an approach for the optimal allocation of distributed generators (DG) in power distribution systems for the total loss reduction using the genetic algorithms technique. In the optimization process, the load demand uncertainties and load scenarios along the day were considered aiming an appropriate representation of the real operation of the distribution systems, which allows a wiser evaluation of the optimal bus to allocate the DG. The proposed approach was performed in the IEEE 13, IEEE 34 and IEEE 123 test systems, presenting inherent characteristics from distribution systems. Resumo: Este artigo apresenta uma abordagem para alocação ótima de geradores distribuídos (GD) em sistemas de distribuição de energia para a redução total de perdas utilizando a técnica de algoritmos genéticos. No processo de otimização, as incertezas da demanda das cargas e os cenários de carregamento ao longo do dia foram considerados, visando uma representação adequada da operação real dos sistemas de distribuição, o que permite uma avaliação mais criteriosa da barra ideal para alocação de GD. A abordagem proposta foi executada nos sistemas teste IEEE 13, IEEE 34 e IEEE 123, que apresentam características inerentes aos sistemas de distribuição.
Impact of DDT residues in feed on thyroid gland and liver secretory activity of Aberdeen-Angus cattle depending on cattle age and sex

1 South Ural State Agrarian University, st. Gagarina 13, 457100, Troitsk, Chelyabinsk Region, Russia 2 Republican Veterinary Laboratory of the Committee for Veterinary Control and Supervision of the Ministry of Agriculture of the Republic of Kazachstan, st. Zarechnoye, Yubileynaya 5a, 111108, Kostanay, Kazachstan 3 Institute of Plant Protection National Research Institute, Chełmońskiego 22, 15-195, Białystok, Poland
The role of religious coping as a moderator of the relationship between psychological burden and quality of life among caregiver of women with breast cancer

Penelitian ini bertujuan untuk mengetahui hubungan antara beban psikologis dengan kualitas hidup yang dimoderatori oleh koping religius pada caregiver wanita dengan kanker payudara. Subjek penelitian ini berjumlah 70 responden yang merupakan caregiver keluarga wanita dengan kanker payudara di Ruang Instalasi Kanker Terpadu “Tulip” RSUP Dr. Sardjito. Terdapat tiga alat ukur yang digunakan dalam penelitian diantaranya WHOQOL-BREF yang sudah diadaptasi sebelumnya ke dalam bahasa Indonesia untuk mengukur kualitas hidup, skala beban psikologis untuk mengukur beban psikologis dan skala koping religius untuk mengukur koping religius yang mana kedua skala merupakan skala yang sudah digunakan dalam penelitian sebelumnya dan dimodifikasi. Analisis data menggunakan Moderated Regression Analysis . Hasil penelitian ini menunjukkan bahwa beban psikologis secara signifikan memprediksi kualitas hidup (B= -0,388, p kurang dari 0,01) dengan sumbangan efektif sebesar 15,0 persen, sedangkan koping religius tidak terbukti memoderatori hubungan antara beban psikologis dan kualitas hidup (p lebih dari 0,05). Kesimpulan dari penelitian ini adalah beban psikologis dapat mempengaruhi kualitas hidup pada caregiver wanita dengan kanker payudara. Koping religius tidak memoderatori hubungan antara beban psikologis dan kualitas hidup pada caregiver wanita dengan kanker payudara. Abstract . The aim of this study is to determine the relationship between psychological burden and quality of life moderated by religious coping among caregivers of women with breast cancer. A total of subjects in this study were 70 family caregivers of women with breast cancer in the Intensive Cancer Center “Tulip” Dr. Sardjito Hospital. Data were collected using three scales such as WHOQOL-BREF to measure the quality of life which has been previously adapted in Bahasa Indonesia, and Psychological Burden Scale to measure psychological burden and the Religious Coping Scale to measure religious coping were both measurements from a previous study which was modified to fit the subjects of study. Analysis of data using Moderated Regression Analysis. This study showed that psychological burden significantly predicts the quality of life (B= -0,388; p less than 0,01) with effective contribution 15 percent, whereas religious coping was not proven to moderate the relation between psychological burden and quality of life (p more than 0,05). In conclusion, the psychological burden could affect the quality of life among caregivers of women with breast cancer. Religious coping did not moderate the relationship between psychological burden and quality of life among caregivers of women with breast cancer.