Miracle-dz/UniFAR-FTUs huggingface dataset:
Local recurrence of diminutive colorectal polyps after cold forceps polypectomy with jumbo forceps followed by magnified narrow-band imaging: a multicenter prospective study

Background Cold polypectomy has been increasingly used to remove diminutive colorectal polyps. We evaluated the local recurrence rate of diminutive polyps at the 1-year follow-up after cold forceps polypectomy (CFP). Methods In a prospective, multicenter, observational cohort study, patients with diminutive colorectal polyps ( ≤ 5 mm) were treated by CFP using jumbo forceps followed by magnified narrow-band imaging (NBI). Patients were assessed for local recurrence at 1-year follow-up. Risk factors associated with local recurrence were analyzed using logistic regression analysis. Results Overall, 955 lesions were resected in 471 patients who completed the 1-year follow-up. The endoscopic complete resection rate was 99.4 %. Immediate and delayed bleeding occurred in 0.8 % and 0.2 % of cases, respectively, with no perforations observed. Local recurrence occurred in 2.1 % of cases at the 1-year follow-up. Univariable analyses indicated that polyps > 3 mm (P < 0.01) and immediate bleeding (P = 0.04) were significantly associated with local recurrence. A trend was observed for patients ≥ 65 years (P = 0.06) and fractional resection (P = 0.09). Multivariable analyses confirmed that lesions > 3 mm were significantly associated with local recurrence (odds ratio 3.4, P = 0.02). Conclusions CFP with jumbo forceps followed by NBI-magnified observation had a low local recurrence rate and is an acceptable therapeutic option for diminutive colorectal polyps. Although we recommend limiting the use of CFP with jumbo forceps to polyps ≤ 3 mm in size, future comparative studies are needed to make recommendations on cold polypectomy using either forceps or snares as the preferred approach for diminutive polyp resection.
Change in Bone Density and Reduction in Fracture Risk: A Meta‐Regression of Published Trials

Meta‐analyses conducted >15 years ago reported that improvements in bone mineral density (BMD) were associated with reduction in vertebral and nonvertebral fractures in osteoporosis trials. Numerous studies have been conducted since then, incorporating new therapies with different mechanisms of action and enrolling many more subjects. To extend these prior analyses, we conducted a meta‐regression of 38 placebo‐controlled trials of 19 therapeutic agents to determine the association between improvements in BMD and reductions in fracture risk. We used a linear model to examine the relationship between mean percent difference in BMD change between treatment and placebo groups and the logarithm of the relative risk. We found that greater improvements in BMD were strongly associated with greater reductions in vertebral and hip fractures but not nonvertebral fractures. For vertebral fracture, the r2 values for total hip, femoral neck, and lumbar spine BMD change were 0.56, 0.54, and 0.63, respectively (p ≤ 0.0002). For a 2% or 6% improvement in total hip BMD, we might expect a 28% or 66% reduction, respectively, in vertebral fracture risk. For hip fracture, the r2 values for total hip, femoral neck, and lumbar spine BMD change were 0.48 (p = 0.01), 0.42 (p = 0.02), and 0.22 (ns), respectively. For a 2% or 6% improvement in total hip BMD, we might expect a 16% or 40% reduction in hip fracture risk. In conclusion, our results extend prior observations that larger improvements in dual‐energy X‐ray absorptiometry (DXA)‐based BMD are associated with greater reductions in fracture risk, particularly for vertebral and hip fractures. Although these results cannot be directly applied to predict the treatment benefit in an individual patient, they provide compelling evidence that improvements in BMD with osteoporosis therapies may be useful surrogate endpoints for fracture in trials of new therapeutic agents. © 2019 American Society for Bone and Mineral Research.
Coverage-Versus-Length Plots, a Simple Quality Control Step for de Novo Yeast Genome Sequence Assemblies

Illumina sequencing has revolutionized yeast genomics, with prices for commercial draft genome sequencing now below $200. The popular SPAdes assembler makes it simple to generate a de novo genome assembly for any yeast species. However, whereas making genome assemblies has become routine, understanding what they contain is still challenging. Here, we show how graphing the information that SPAdes provides about the length and coverage of each scaffold can be used to investigate the nature of an assembly, and to diagnose possible problems. Scaffolds derived from mitochondrial DNA, ribosomal DNA, and yeast plasmids can be identified by their high coverage. Contaminating data, such as cross-contamination from other samples in a multiplex sequencing run, can be identified by its low coverage. Scaffolds derived from the bacteriophage PhiX174 and Lambda DNAs that are frequently used as molecular standards in Illumina protocols can also be detected. Assemblies of yeast genomes with high heterozygosity, such as interspecies hybrids, often contain two types of scaffold: regions of the genome where the two alleles assembled into two separate scaffolds and each has a coverage level C, and regions where the two alleles co-assembled (collapsed) into a single scaffold that has a coverage level 2C. Visualizing the data with Coverage-vs.-Length (CVL) plots, which can be done using Microsoft Excel or Google Sheets, provides a simple method to understand the structure of a genome assembly and detect aberrant scaffolds or contigs. We provide a Python script that allows assemblies to be filtered to remove contaminants identified in CVL plots.
Remembering to Forget: Identity, Mourning and Memory Among the Jivaro

L'identite personnelle jivaro est construite a partir de 2 elements : une silhouette humaine singuliere - essentiellement un visage - puisee dans le stock fini des « formes-personnes » et des noms composant l'humanite ; ensuite une virtualite de trajectoire existentielle ou de destinee heroique. Or ces constituants de la personne viennent des morts qu'on a consignes a l'oubli. L'A. met en lumiere les aspects cognitifs du deuil jivaro en tant que mecanisme d'oubli des morts recents. A partir de l'etude d'une perte de parents tues lors de vendettas intertribales et de celle de proches decapites lors des raids de chasse aux tetes intertribaux, l'A. retrace les transformations de la conscience projetee sur les morts et vecues par les vivants au cours du deuil. Il explore la maniere dont les relations aux morts, et les moyens psychologiques pour les effacer de la memoire, determinent les formes de la conscience et du discours historique.
The Arrowhead Agility Test: Reliability, Minimum Detectable Change, and Practical Applications in Soccer Players.

Rago, V, Brito, J, Figueiredo, P, Ermidis, G, Barreira, D, and Rebelo, A. The arrowhead agility test: Reliability, minimum detectable change, and practical applications in soccer players. J Strength Cond Res XX(X): 000-000, 2019-Four independent studies were conducted to examine the utility of the arrowhead agility test (AAT) to measure change of direction (COD) capacity in soccer players, specifically, (a) intersession reliability and minimum detectable change (n = 24); (b) power-dependent abilities associated with AAT performance (n = 56); and (c) fatigue sensitivity (n = 20); differences between competitive levels and age groups (n = 264). Irrespective of the AAT outcome measure (skillful side, less-skillful side, sum of both), intersession reliability and the ability to detect changes in performance were good (ICC = 0.80-0.83; CV = 1.25-2.21%; smallest worthwhile change, 0.06-0.12 >SEM, 0.01-0.03) except for the asymmetry index. A 15-m sprint explained a significant amount of variance in COD (p < 0.01; R = 0.42). Arrowhead agility test performance did not change from the prematch toward half time (p = 0.21). However, reduced COD performance was observed after an intense period in the second half and after the game, compared with prematch and half-time performance (p < 0.05; effect size [ES] = -0.85 to 0.42). Irrespective of age group, national players were more agile than regional players (p < 0.05; ES = -1.97 to -0.36). Moreover, independently of their competitive level, senior and U18 players had a better performance than U16 (p < 0.05; ES = -2.33 to -0.84), whereas no significant differences were observed between senior and U18. Percentiles were also reported in the results. The AAT is reliable to measure COD in soccer players. The test may simultaneously encompass 15-m sprint testing but should be implemented independently to countermovement jump. Furthermore, the test is sensitive to match-induced fatigue during the second half and discriminates players from different competitive levels.
Morse Theory and Tilting Sheaves

Tilting perverse sheaves arise in geometric representation theory as natural bases for many categories. (See [1] or Section 3 below for definitions and some background results.) For example, for category O of a complex reductive group G, tilting modules correspond to tilting sheaves on the Schubert stratification S of the flag variety B. In this setting, there are many characterizations of tilting objects involving their categorical structure. (See [13] and [14].) In this paper, we propose a new geometric construction of tilting sheaves. Namely, we show that they naturally arise via the Morse theory of sheaves on the opposite Schubert stratification Sopp.
Late-onset neonatal sepsis: Overview of risk factors and bacterial etiology in a tertiary care hospital in North India

Background: Septicemia in neonates is one of the leading causes of mortality. The increasing number of multidrug-resistant pathogens is a serious concern. With this background, this study was done to evaluate the risk factors of late-onset sepsis (LOS) (community- and hospital-acquired infections) in newborns and to determine the antibiotic resistance pattern of the isolates in these infections. Materials and Methods: This retrospective study was conducted at Sarojini Naidu Medical College, Agra, on newborns admitted between August 2015 and January 2016. Newborns with the final diagnosis of sepsis obtained from the case records during the study period were included in the study. Those newborns with positive blood culture results were included in the study. Clinical details and antibiotic sensitivity of the isolates were also obtained from the records. Results: Sixty-eight newborns with LOS (38 community- and 30 hospital-acquired infections) were included in the study. Staphylococcus and Klebsiella were the most common bacteriological isolates for both community- and hospital-acquired infection cases in 36%, 26% and 26%, 33.3%, respectively. Home delivery (52.6%) and faulty breastfeeding were (57.8%) seen in significantly larger numbers in community-acquired infections (P = 0.03 and 0.01, respectively) whereas invasive procedures such as intubation were seen in 40% of nosocomial infections as compared to only 5.2% of community-acquired infections. Antibiotic susceptibility pattern in both the infections was similar. Staphylococcus aureus was susceptible to vancomycin in 100% cases while high resistance was seen for ampicillin in both the groups. Similarly, gentamicin was found to be resistant in both the groups for Klebsiella while imipenem was susceptible in 100% cases. Conclusion: Both community- and hospital-acquired infections had similar isolates and antibiotic susceptibility pattern; however, the risk factors associated with both the infections differed.
Exploiting Alignments in Linked Data for Compression and Query Answering

Joshi, Amit Krishna. Ph.D., Department of Computer Science & Engineering, Wright State University, 2017. Exploiting Alignments in Linked Data for Compression and Query Answering. Linked data has experienced accelerated growth in recent years due to its interlinking ability across disparate sources, made possible via machine-processable RDF data. Today, a large number of organizations, including governments and news providers, publish data in RDF format, inviting developers to build useful applications through reuse and integration of structured data. This has led to tremendous increase in the amount of RDF data on the web. Although the growth of RDF data can be viewed as a positive sign for semantic web initiatives, it causes performance bottlenecks for RDF data management systems that store and provide access to data. In addition, a growing number of ontologies and vocabularies make retrieving data a challenging task. The aim of this research is to show how alignments in the Linked Data can be exploited to compress and query the linked datasets. First, we introduce two compression techniques that compress RDF datasets through identification and removal of semantic and contextual redundancies in linked data. Logical Linked Data Compression is a lossless compression technique which compresses a dataset by generating a set of new logical rules from the dataset and removing triples that can be inferred from these rules. Contextual Linked Data Compression is a lossy compression technique which compresses datasets by performing schema alignment and instance matching followed by pruning of alignments based on confidence value and subsequent grouping of equivalent terms. Depending on the structure of the dataset, the first technique was able to prune more than 50% of the triples. Second, we propose an Alignment based Linked Open Data Querying System (ALOQUS) that allows users to write query statements using concepts and properties not present in linked datasets and show that querying does not require a thorough understanding of the individual datasets and interconnecting relationships. Finally, we present LinkGen, a multipurpose synthetic Linked Data generator that generates a large amount of repeatable and reproducible RDF data using statistical distribution, and interlinks with real world entities using alignments.
On the Road to Conventionalization: Analyses of Nominal Coercion

Conventionalization • Not all instances of coercion are the same • Coercive determiner-noun combinations vary widely in frequency • In novel cases like (3) we may resolve the semantic conflict between “a” and “mud” by creating an innovative meaning (a type or brand of mud) • In conventionalized cases like (1) the adjusted interpretation (a portion of beer) has become so entrenched that we may not recognize it as being noncompositional • Coercion may be more frequent within certain semantic frames (e.g., within the RESTAURANT frame we often refer to portions and varieties of mass nouns) • Processing a coercion instance may be strongly shaped by frequency and therefore conventionalized instances may be easy to process and integrate
Assessing Evidence-Based Dermatology and Evidence-Based Internal Medicine Curricula in US Residency Training Programs—Editor's Comment

Objectives: To examine attitudes toward evidence-based medicine and evidence-based dermatology and to assess evidence-based training in US internal medicine and dermatology residency programs. Methods: A 1-page self-administered questionnaire was mailed to residency training directors and chief residents at 104 dermatology and 103 internal medicine residency programs from the same or affiliated medical centers. Results: Questionnaires were returned by respondents from 70 (68%) of 103 internal medicine programs and 86 (83%) of 104 dermatology programs. Most respondents (91% internal medicine and 70% dermatology) strongly agreed or agreed that evidence-based internal medicine/dermatology is valuable and should be in-cluded in residency training (93% internal medicine and 70% dermatology). Respondents from internal medicine programs agreed strongly with both state-ments than respondents from dermatology programs ( P =.001). Dedicated evidence-based curricula were in place at significantly more internal medicine programs (50 [71%] of 70) than dermatology programs (20 [23%] of 86) ( P (cid:1) . 001). Curricula at internal medicine programs offered significantly more evidence-based medicine training sessions (24 vs 6; P (cid:1) and biostatistics sessions (10 vs 2.3; P =.03), and internal medicine programs more frequently evaluated the curricula using clinical question applications (56% vs 30%; P =.04). Conclusion: Despite attitudes toward programs.
Nonpharmacologic Measures to Prevent Ventilator-Associated Pneumonia

Ventilator-associated pneumonia (VAP) continues to be an important cause of morbidity and mortality in critically ill patients. Despite the numerous contributions in the field of the prevention of VAP in the last decade, the majority of issues related to the prevention of VAP remain unresolved and are subject to controversy. This review aims to summarize the nonpharmacologic measures for prevention of VAP and could help to design a VAP care bundle to prevent VAP as follows: oral rather than nasal intubation, maintenance of endotracheal tube cuff pressure between 20 and 30 cm of water, subglottic secretion drainage in patients expected to need mechanical ventilation longer than 72 hours, early extubation, avoidance of reintubation, use of noninvasive ventilation, early tracheostomy in patients expected to require prolonged mechanical ventilation, no routine change of ventilator circuits, heat and moisture exchanger when short-term mechanical ventilation is expected and heated humidifier when prolonged mechanical ventilation is expected, closed tracheal suctioning system rather than an open system, no routine change of closed tracheal suctioning system, sterilization of reusable respiratory devices, barrier infection-control measures, and semirecumbent position.
Tokyo Cabinet：超越键／值存储

Ruby从Matz的一个研究项目到成为我们熟悉的编程语言，耗费了不短的时间。 现在，另一位日本程序员平林斡雄（Mikio Hirabayashi）和他的新数据库项目Tokyo Cabinet完全有潜力重复这个成功故事。 Tokyo Cabinet由MixiInc．（日本的Facebook）开发及资助，它是一个高效且功能丰富的数据库。 事实上，以该项目的成熟度来说，这个项目能找到的资料除了日文之外真是少的可怜。 这里我们就来简单地了解一下它吧。
Generalized controller canonical form for linear and nonlinear dynamics

A generalized controller canonical form for linear and nonlinear dynamics is proposed. It is obtained using the theorem of the primitive element from differential algebra. The derivation of the controller form does not apply to multivariable constant linear systems. With the transformations, all nonlinear dynamics can be exactly linearized by dynamic feedback. The main departure from standard theory is that transformations may depend on input derivatives. Once differential-algebraic tools are introduced, the proofs of the results are easy. >
Cyto-morphologic correlation of equivocal C3 and C4 breast lesions

Background: National Cancer Institute (NCI) formulated a five-tiered system for reporting cytological smears from the breast. Of these, C1, C2 and C5 are usually unequivocal. The equivocal categories C3 (atypical probably benign) and C4 (suspicious probably malignant) need to be evaluated to determine their cyto-morphologic correlation and thus provide useful information on the degree of clinical weight that can be put on them in patient management. Patients and Methods: A retrospective study of cytological smears made from palpable breast lesions performed over a 5-year period from 2008-2012. The C3 and C4 smears were then compared with final histological diagnoses for these categories and their diagnostic value calculated. Result: There were 1,162 smears taken over the study period, and 200 (17.2%) had subsequent histology. Of the 200 smears, 20 were C3 and 27 were designated as C4. Subsequent histology upgraded 7 (35%) of the C3 cases to malignant and 23 (85%) of the 27 C4 cases were malignant. The difference between these two proportions is statistically significant (P < 0.005). The overall Suspicious Rate was 23.5% and C4 reports had a sensitivity of 76.7%, specificity of 76.5%, positive and negative predictive values of 85.2% and 65.0% respectively. Conclusion: A fair degree of clinical reliance can still be placed on cytologically categorized C3 and C4 breast smears. However, the rate of reporting of these categories can be reduced with availability of ancillary radiological techniques such as mammography and ultrasonography.
IL-10 resolves the neutrophilic inflammation in mice exposed to cigarette smoke

Introduction: IL-10 plays a suppressive role in the inflammation. In order to elucidate the role of IL-10 in the inflammation caused by cigarette smoke, mice exposed to cigarette smoke were investigated. Materials & methods: Mice (C57BL/6J) were exposed either to cigarette smoke or to environmental air for 5, 8 or 12 days. To characterize the inflammation, cellularity in bronchoalveolar lavage (BAL) fluid was investigated. The levels of inflammation-associated cytokines, such as IL-10, KC, MIP-2, TNF-a and GM-CSF, were further determined by measuring both mRNA levels in the lung tissues and the protein levels in BAL fluid. Then, a group of mice was intranasally treated either with recombinant murine IL-10 or with vehicle and exposed to cigarette smoke, before the same analysis was performed. Results: Cigarette smoke exposure provoked pulmonary inflammation in mice, as neutrophil and macrophage counts in BAL fluid were increased (p Conclusion: Our results suggested that IL-10 potentiates the suppression of the neutrophil-associated inflammatory reactions caused by cigarette smoke exposure.
Single-carrier modulation technology for very high-speed digital subscriber line

This article gives an overview of very high-speed digital subscriber lines, including the main issues of VDSL system design, such as its basic architecture, applications, and data rates, as well as the technological challenges of practical implementation due to different loop plant realities and spectral compatibility considerations. Some specific characteristics of the VDSL transceiver startup procedure and high-level architecture, as well as a summary of first laboratory tests and field trials, are also presented. The article concentrates on VDSL implementations using single-carrier modulation, which integrates the well-known carrierless amplitude/phase modulation and quadrature amplitude modulation technologies. Currently, SCM technology is considered one of the main candidates for the VDSL standard in the United States and Europe, and internationally.