Miracle-dz/UniFAR-FTUs huggingface dataset:
Teachers’ Burnout: The Role of Trait Emotional Intelligence and Social Support

The current study investigates the relations among teachers’ trait emotional intelligence, internal and external social support, and their levels of burnout. We hypothesized that both emotional intelligence and teachers’ perceived social support were associated with low level of teachers’ burnout. We further expected that internal and external support mediated the relationship between trait emotional intelligence and burnout scores. Participants were 318 in-service Italian teachers. The structural equation modeling analysis supports the idea that teachers’ trait emotional intelligence is strongly and directly associated with their burnout. Furthermore, internal social support (from the teachers’ workplace relationships) was more effective on burnout than support forthcoming from their external context. On the contrary, the mediation hypothesis was partially supported by the empirical data. These findings shed light on the relationship between teachers’ emotional competence and their burnout experience at school.
Protein Amphipathic Helix Insertion: A Mechanism to Induce Membrane Fission

One of the fundamental features of biomembranes is the ability to fuse or to separate. These processes called respectively membrane fusion and fission are central in the homeostasis of events such as those related to intracellular membrane traffic. Proteins that contain amphipathic helices (AHs) were suggested to mediate membrane fission via shallow insertion of these helices into the lipid bilayer. Here we analyze the AH-containing proteins that have been identified as essential for membrane fission and categorize them in few subfamilies, including small GTPases, Atg proteins, and proteins containing either the ENTH/ANTH- or the BAR-domain. AH-containing fission-inducing proteins may require cofactors such as additional proteins (e.g., lipid-modifying enzymes), or lipids (e.g., phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2], phosphatidic acid [PA], or cardiolipin). Both PA and cardiolipin possess a cone shape and a negative charge (−2) that favor the recruitment of the AHs of fission-inducing proteins. Instead, PtdIns(4,5)P2 is characterized by an high negative charge able to recruit basic residues of the AHs of fission-inducing proteins. Here we propose that the AHs of fission-inducing proteins contain sequence motifs that bind lipid cofactors; accordingly (K/R/H)(K/R/H)xx(K/R/H) is a PtdIns(4,5)P2-binding motif, (K/R)x6(F/Y) is a cardiolipin-binding motif, whereas KxK is a PA-binding motif. Following our analysis, we show that the AHs of many fission-inducing proteins possess five properties: (a) at least three basic residues on the hydrophilic side, (b) ability to oligomerize, (c) optimal (shallow) depth of insertion into the membrane, (d) positive cooperativity in membrane curvature generation, and (e) specific interaction with one of the lipids mentioned above. These lipid cofactors favor correct conformation, oligomeric state and optimal insertion depth. The most abundant lipid in a given organelle possessing high negative charge (more negative than −1) is usually the lipid cofactor in the fission event. Interestingly, naturally occurring mutations have been reported in AH-containing fission-inducing proteins and related to diseases such as centronuclear myopathy (amphiphysin 2), Charcot-Marie-Tooth disease (GDAP1), Parkinson’s disease (α-synuclein). These findings add to the interest of the membrane fission process whose complete understanding will be instrumental for the elucidation of the pathogenesis of diseases involving mutations in the protein AHs.
Open Science, Open Data, and Open Scholarship: European Policies to Make Science Fit for the Twenty-First Century

Open science will make science more efficient, reliable, and responsive to societal challenges. The European Commission has sought to advance open science policy from its inception in a holistic and integrated way, covering all aspects of the research cycle from scientific discovery and review to sharing knowledge, publishing, and outreach. We present the steps taken with a forward-looking perspective on the challenges laying ahead, in particular the necessary change of the rewards and incentives system for researchers (for which various actors are co-responsible and which goes beyond the mandate of the European Commission). Finally, we discuss the role of artificial intelligence (AI) within an open science perspective.
Synthesis and Electroluminescent Properties of Through-Space Charge Transfer Polymers Containing Acridan Donor and Triarylboron Acceptors

We report the design, synthesis and electroluminescent properties of three kinds of through-space charge transfer (TSCT) polymers consisting of non-conjugated polystyrene backbone, acridan donor and triarylboron acceptors having different substituents such as hydrogen (H), fluorine (F), and trifluoromethyl (CF3). Owing to the weak electron interaction between acridan donor and triarylboron acceptor through non-conjugated connection, blue emission with peaks in range of 429–483 nm can be achieved for the polymers in solid-state film, accompanied with photoluminescence quantum yields of 26–53%. The resulting TSCT polymers exhibit small ΔEST values below 0.1 eV owing to the separated HOMO and LUMO distributions, showing thermally activated delayed fluorescence with lifetimes in range of 0.19–0.98 μs. Meanwhile, the polymers show aggregation-induced emission (AIE) effect with the emission intensity increased by up to ~33 folds from solution to aggregation state. Solution-processed organic light-emitting diodes based on the polymers containing trifluoromethyl substituent exhibit promising electroluminescent performance with maximum luminous efficiency of 20.1 cd A−1 and maximum external quantum efficiency of 7.0%, indicating that they are good candidates for development of luminescent polymers.
Convolutional networks for traffic sign classification

Traﬃc sign classiﬁcation is an important task in autonomous driving and assistant driving systems. In this thesis we do automatic learning of features and classiﬁcation on traﬃc signs from images. First, we study several publicly available libraries for deep learning. Several CNN architectures are then tested under diﬀerent parameter settings and scenarios, such as network depth, ﬁlter size, dropout rate and preprocessing by using original images and segmented images. The German Traﬃc Sign Recognition Benchmark was used to train in a supervised way the CNN model. Preprocessing and segmentation are tested to make the training more robust and the network able to generate more independent features. The results obtained are good for all study cases and all 43 traﬃc sign classes. We reached test accuracies above 98% that are comparable to state of the art performances.
Teaching nursing skills in the clinical environment

“What is the correct size” is one of the questions most commonly asked when requesting students to set up for a catheter placement; in this scenario, the student is relying on the tutor to provide the answer. However, answering the student’s question directly will eliminate the opportunity for the student to recall or apply previous knowledge or experiences or to develop problem-solving skills (Towle & Cottrell, 1996).
Relationship between general health, occupational stress and burnout in critical care nurses of Tabriz teaching hospitals

Background and Aim: Occupational stress in nursing profession can result in poor nursing care and health problems. Bornout is the other problem in nursing practice that could result in absenteeism, low energy and low nursing care efficiency. In the other hand, high stress can result in mental disorders like depression. This study was carried out to determine levels of occupational stress, burnout and general health in critical nurses of Tabriz teaching hospitals. Materials and Method: This was a fragment of a larger cross-sectional study in which 63 nurses, working in critical care units of Tabriz teaching hospitals, were selected. Data were gathered by Occupational stress questionaire, Maslach Burnout Inventory and General Health Questionaire. Data were analyzed using Chi-square test and Pearson correlation coefficient. Results: The findings indicated that total levels of occupational stress in majority of nurses (49.2%) was high. Regarding burnout, 44.4% of nurses had high levels of burnout in emotional exhaustation aspect and 46.0% of nurses had high levels of burnout in personal accomplishment aspect. The majority of nurses (42.4%) reported high levels of anexeity. There was a statistically significant relationship of emotional exhaustation with occupational stress (P(cid:6)0.05) and mental helth was (P(cid:6)0.05). Conclusion: Occupational stress and burnout may have undesired influences on nursing function and mental health. Stratetegies decreasing stress and burnout can promote nursing mental health and quality of care.
Blepharophimosis, Ptosis, and Epicanthus Inversus Syndrome: Expanding the Phenotype

We present a 3-month-old girl who displayed typical clinical characteristics of blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES). She was referred to our clinic with an initial diagnosis of Down syndrome. Clinical features of elevated follicle stimulating hormone and low estradiol levels in the case were diagnosed as BPES syndrome and were consistent with BPES type 2. To date, there are no cases of BPES with cleft palate and cardiomyopathy, suggesting that these novel findings can be part of this condition.
Accuracy of Self-reported Height and Weight in low-income, Rural AfricanAmerican Children

Objective: To validate self-report anthropometric data in a sample of low-income, rural African American youth. Methods: Ninety-two youth, 10.16 ± 0.85 years of age, were recruited from one school in a rural area of the southeast U.S. Youth were asked to self-report height and weight prior to having their height and weight measurements recorded by trained researchers. Body Mass Index (BMI) was calculated and BMI percentile rank (BMIpct) were used to classify adolescents as non-overweight/obese or overweight/obesity. Differences between measured and self-reported values were assessed using paired t-tests, and differences between weight categories were examined with independent t-tests. Agreement between classification of overweight/obesity by self-report and measured values was assessed using Chi Square. Results: Self-report and measured weight, but not height, differed significantly with the self-reported weight value being 3.1 kg lower than the measured value. Neither height nor weight differed between methods for nonoverweight/ obese youth. For overweight/obese youth, height values were similar but weight values differed between methods (p<0.001) with overweight/obese youth under-reporting their weight to a greater extent than nonoverweight/ obese youth (-8.3 + 9.9 vs. -0.74 + 5.0; p<0.001). The prevalence of overweight/obesity from measured values was 31.5% compared to 30.4% from self-reported values. However, the sensitively was low (58.6%) because of overweight/obese youth’s inability to accurately self-report their weight. Conclusion: The use of self-reported heights and weights for deriving estimates of overweight/obesity rates in lower-income, rural African American youth was not supported by this study
Evaluation of patient-controlled sedation (PCS) during surgical removal of impacted lower third molars.

Objectives: The current study was conducted to evaluate the safety of patient-controlled sedation (PCS) and the efficiency of elastomeric infusion device during surgical removal of impacted lower third molars and its impact on patients regarding level of sedation, p atients’ satisfaction and psycho-motor recovery. Materials and methods: Twenty patients were equally divided into two groups chosen randomly. In both groups, 0.03 mg/kg Midazolam and 0.5 mg/kg Propofol were administered IV as a bolus dose. Group 1 was then given 0.3 mg/kg/hr Ketamine and 1.2 mg/kg/hr Propofol as a maintenance dose delivered through the PCS pump. Group 2 was then given 0.3 µg/kg/hr Fentanyl and 1.2 mg/kg/hr Propofol as a maintenance dose delivered through the PCS pump . For all patients’ surgical procedure were done under local anesthesia. Before going to the operating theatre all patients were instructed about the PCS pump and familiarized with it. Patients in both groups were evaluated for hemodynamic stability, patient's &surgeon's satisfaction, psychomotor recovery and adverse effects. Results: The results of this study showed no statistical difference between the two groups. The use of different drug combinations in both groups showed hemodynamic stability, patients’& surgeon's satisfaction and rapid psychomotor recovery. None of the patients in both groups suffered from any adverse reactions such as : nausea, vomiting, hallucinations, involuntary movements, or over-sedation. Conclusion: PCS can be considered as a safe option in minor oral surgeries providing the majority of patients with high satisfaction and relaxation, also providing the surgeons with good operating conditions and the cooperation of the majority of the patients. Fentanyl-Propofol and Ketamine-Propofol combinations were both safe with respect to hemodynamic changes with rapid recovery of psychomotor functions in all patients.
Cerebrospinal fl uid analyses in Thai multiple sclerosis patients

Objective: To evaluate cerebrospinal fl uid (CSF) patterns in Thai multiple sclerosis (MS) patients particularly oligoclonal bands compared with Western MS. Methods: Retrospective review of 72 patients from the MS Clinic, Siriraj Hospital, between January 1997 and June 2004. All were diagnosed MS using the Poser ’ s criteria. Results: Seventy-six patients were evaluated. There were 62 female (86.1%),10 male (13.9%) with a female:male ratio of 6.2:1. The mean age at onset was 33.11±11.76 years. The mean duration of disease was 6.62 ± 5.9 years. Among the 56 MS patients, 52 patients (72.2%) had relapsing-remitting course, 3 (4.2%) had progressive relapsing course, 1(1.4%) had secondary progressive course, none had primary progressive course. Eleven patients (15.3%) had possible MS and the remaining 5 patients had Devic’s syndrome. Approximately 46% had CSF white blood cell (WBC) less than 5 cells/μL. Only 1 (2.3%) had CSF WBC count more than 50 cells/μL. However, both opticospinal form and classic form of MS similarly showed mononuclear cell predominant in differential CSF WBC count. Presence of CSF oligoclonal bands in defi nite MS patients was low in prevalence of only 27.3%. Conclusion: The CSF of Thai MS patients have lower incidence of oligoclonal bands compared with the reports from western countries.
Steering hyper-giants' traffic at scale

Large content providers, known as hyper-giants, are responsible for sending the majority of the content traffic to consumers. These hyper-giants operate highly distributed infrastructures to cope with the ever-increasing demand for online content. To achieve commercial-grade performance of Web applications, enhanced end-user experience, improved reliability, and scaled network capacity, hyper-giants are increasingly interconnecting with eyeball networks at multiple locations. This poses new challenges for both (1) the eyeball networks having to perform complex inbound traffic engineering, and (2) hyper-giants having to map end-user requests to appropriate servers. We report on our multi-year experience in designing, building, rolling-out, and operating the first-ever large scale system, the Flow Director, which enables automated cooperation between one of the largest eyeball networks and a leading hyper-giant. We use empirical data collected at the eyeball network to evaluate its impact over two years of operation. We find very high compliance of the hyper-giant to the Flow Director's recommendations, resulting in (1) close to optimal user-server mapping, and (2) 15% reduction of the hyper-giant's traffic overhead on the ISP's long-haul links, i.e., benefits for both parties and end-users alike.
TeDia - A Telemedicine-Based Treatment Model for Inpatient and Interprofessional Diabetes Care

Introduction The proportion of hospitalized patients with diabetes as a secondary diagnosis increases continuously. Therefore, we have developed a team-based interprofessional and telemedicine-based diabetes management system named TeDia (“Telemedical Diabetology”) and implemented it in an inpatient setting. The aim of the retrospective real-world study was to show the clinical impact of TeDia following its implementation. Material and methods TeDia is characterized by an interpersonal and telemedicine-based exchange of hospital routine data between specially trained nurses (“diabetes managers”) and external diabetologists. It was implemented in three acute hospitals of the Düsseldorf Catholic Hospital Group in Düsseldorf, Germany. Clinical awareness of diabetes, diabetes-related complications and diagnosis-related group (DRG)-based revenues were analyzed using ICD routine coding. Furthermore, the frequency of HbA1c determinations as well as hospitalization days were investigated. Results Before (2010), during (2012) and after the implementation of TeDia (2014), the number of patients with ICD coding for diabetes, decompensated diabetes, diabetic neuropathy, diabetic nephropathy as well as complicated diabetes increased by +18%, +93%, +101%, +113% and +89%, respectively. Using the same DRG grouper, revenues increased by +53% (from 27 (2013) to 42 (2014) DRG points). Frequency of HbA1c determinations rose by +85%, whereas the time for an average length of stay decreased by −12% (−0, 91 days) in comparison to patients without diabetes. Conclusion TeDia improved clinical awareness for diabetes and its complications. This new treatment model increased revenues and reduced hospital days indicating enhanced treatment quality. Our findings emphasize the necessity of novel technologies in inpatient settings for the improvement of efficacy, safety and efficiency of diabetes care.
Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials

Aim The aims of this study were to investigate new nano-formulations based on ZnO and Ag nanoparticle (NP) compounds when used against clinical strains of oral gram-positive and gram-negative bacteria, and to examine the stability and behaviour of nano-formulation mixtures in saliva based on different compositions of Ag NPs, ZnO NPs and ZnO+x·Ag NPs. Methods: ZnO NPs with and without nanosilver were obtained by microwave solvothermal synthesis. Then, antibacterial activity was evaluated against bacteria isolated from human saliva. Behavior and nanoparticle solutions were evaluated in human saliva and control (artificial saliva and deionized water). Results were statistically compared. Results The NP mixtures had an average size of 30±3 nm, while the commercial Ag NPs had an average size of 55±5 nm. The suspensions displayed differing antibacterial activities and kinetics of destabilisation processes, depending on NPs composition and fluid types. Conclusion The present study showed that all NPs suspensions displayed significant destabilisation and high destabilisation over the 24 h of the analyses. The agglomeration processes of NPs in human saliva can be reversible.
Long Non-Coding RNA TUG1 Modulates Proliferation, Migration, And Invasion Of Acute Myeloid Leukemia Cells Via Regulating miR-370-3p/MAPK1/ERK

Background Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) has been discovered to participate in multiple cancers including AML. However, the detailed mechanism of TUG1 in AML remains obscure. Materials and methods AML cell lines HL-60 and Kasumi-1 were taken as cell models. TUG1 knockdown or overexpression cell lines were generated. Then, the biological influence of TUG1 on cancer cells was studied using CCK-8 assay, transwell assay and Western blot in vitro. Interaction between TUG1 and miR-370-3p was determined by bioinformatics analysis, RT-PCR, and luciferase assay. Western blot, RT-PCR, and luciferase assay were carried out to validate the interaction between miR-370-3p and its target gene Mitogen-Activated Protein Kinase 1 (MAPK1). Results Knockdown of TUG1 markedly reduced viability and metastasis of AML cells, while its overexpression had the opposite effect. MAPK1 was verified as a target gene of miR-370-3p. TUG1 could reduce the level of functional miR-370-3p, facilitate MAPK1 expression, and in turn activate ERK1/2 signaling. Conclusion TUG1 could modulate malignant phenotypes of AML cells via miR-370-3p/MAPK1/ERK signaling. Our study would help to clarify the mechanism of AML tumorigenesis and progression.
Positive Expiratory Pressure Therapy With And Without Oscillation And Hospital Length Of Stay For Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Introduction Pharmacologic management of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is well-established. Our aim in the current study is to determine if therapy with a positive expiratory pressure (PEP) device with or without an oscillatory mechanism (OM) in addition to standard care results in a reduction in hospital length of stay (LOS) among patients hospitalized for AECOPD. Methods Two studies were performed and are reported here. Study 1: Patients admitted with AECOPD and sputum production were enrolled in a prospective trial comparing PEP therapy versus Oscillatory PEP (OPEP) therapy. Study 2: A retrospective historical cohort, matched in a 2 to 1 manner by age, gender, and season of admission, was compared with the prospectively collected data to determine the effect of PEP ± OM versus standard care on hospital LOS. Results In the prospective trial (Study 1; 91 subjects), median hospital LOS was 3.2 (95% CI 3.0–4.3) days in the OPEP group and 4.8 (95% CI 3.9–6.1) days in the PEP group (p=0.16). In fully adjusted models comparing the prospective trial data with the retrospective cohort (Study 2; 182 subjects), cases had a median hospital LOS of 4.2 days (95% CI 3.8–5.1) versus 5.2 days (95% CI 4.4–6.0) in controls, consistent with a shorter hospital LOS with adjunctive PEP±OM therapy versus standard care (p=0.04). Conclusion Adjunctive therapy with a PEP device versus standard care may reduce hospital LOS in patients admitted for AECOPD. Although the addition of an OM component to PEP therapy suggests a further reduction in hospital LOS, comprehensive multicenter randomized controlled trials are needed to confirm these findings. Clinical trial registration number NCT03094806.
"I like my tutors always": East African Students in a Public Library Homework Help Program

The more than one-hundred year old public library in a small urban city in the northeastern U.S. (henceforth referred to as Riverburg) describes itself as an integral sponsor of knowledge, culture, education, and information in the city and an institution that serves “users of all ages, abilities, and backgrounds” in order to retain status as “both a significant institutional symbol and a core working component of our democratic society” (library website). Perhaps as a result of its history and mission, the library houses an afterschool homework help program that runs most weekdays during the school year. This paper concerns how East African youth (many of whom are immigrant and/or refugee) in the Riverburg Public Library afterschool program, in the words of the program director in a conversation with me in October 2011, “view themselves both as a part of the afterschool program and in relation to the program. ” A sizeable and visible minority group in the community, this group of students faces multiple obstacles to success in the traditional structures of the local public schools, some having to do with factors well outside of their control. The students’ cultural context presents unique challenges for the library afterschool program, which seeks to help these students succeed in school by providing a space where tutors can help them with their homework.