Miracle-dz/UniFAR-FTUs huggingface dataset:
Campylobacter spp em alimentos. Uma revisão

O controle da qualidade dos alimentos e fundamental para que sejam eliminados os riscos de contaminacao da populacao por via alimentar, principalmente por patogenos como as bacterias do genero Campylobacter. Os membros do genero Campylobacter sao definidos como bastonetes gram negativos curvos ou espiralados, requerem baixas concentracoes de oxigenio e altas concentracoes de CO2 para crescimento. Sao extremamente sensiveis ao congelamento, sendo tambem destruidos pela pasteurizacao. Alem disso, sao comumente encontrados no trato intestinal de homens e animais e estao normalmente associados com gastrenterites agudas veiculadas por alimentos. As principais formas de doenca sao a intestinal, e a mais severa, doenca neurologica sindrome de Guillain – Barre (GBS). Podem ser transmitidos para os seres humanos principalmente pela via fecal-oral por contato direto, por consumo de carne crua ou mal cozida, principalmente de frango, ou de agua contaminada. Todavia, a deteccao de Campylobacter spp em alimentos torna-se complicada, devido o fato de que a populacao presente nos produtos e normalmente baixa, decorrente do nao crescimento em temperaturas abaixo de 30oC e extrema sensibilidade a concentracao de oxigenio no ar. Mesmo sendo um microrganismo de grande importância na saude publica, escassas sao as publicacoes em portugues revisando sobre Campylobacter spp em alimentos, sendo assim, este trabalho teve como objetivo revisar as principais caracteristicas e os metodos de deteccao dessa bacteria em alimentos.
Diagonalisation of covariance matrices in quaternion widely linear signal processing

Recent developments in quaternion-valued widely linear processing have illustrated that the exploitation of complete second-order statistics requires consideration of both the covariance and complementary covariance matrices. Such matrices have a tremendous amount of structure, and their decomposition is a powerful tool in a variety of applications, however, this has proven rather difficult, owing to the non-commutative nature of the quaternion product. To this end, we introduce novel techniques for a simultaneous decomposition of the covariance and complementary covariance matrices in the quaternion domain, whereby the quaternion version of the Takagi factorisation is explored to diagonalise symmetric quaternion-valued matrices. This gives new insight into the quaternion uncorrelating transform (QUT) and forms a basis for the proposed quaternion approximate uncorrelating transform (QAUT) which simultaneously diagonalises all four covariance matrices associated with improper quaternion signals. The effectiveness of the proposed uncorrelating transforms is validated by simulations on synthetic and real-world quaternion-valued signals.
Un outil d'évaluation formative et de remédiation pour les cours de tableur

Alors que l’evaluation formative est largement repandue a tous les niveaux de l’enseignement, la formation en ligne n’apparait pour l’heure que dans certains domaines specifiques et n’occupe qu’un role de second plan sur la scene des moyens d’enseignement au service de l’education, du moins en ce qui concerne l’enseignement secondaire au Grand-Duche de Luxembourg. Le role possible de ces technologies pour la formation des eleves est cependant loin d’etre anodin, et les resultats d’ores et deja acquis s’averent tres prometteurs (Maki, Maki, Patterson & Whittaker, 2000; VanLehn, 2011). Ainsi la formation en ligne ne permet-elle pas seulement une evaluation et un apprentissage efficace, flexible et a distance, mais cette nouvelle pratique d’enseignement facilite egalement et surtout l’interaction si necessaire entre l’evaluation et l’apprentissage.
Brentuximab vedotin in transplant-naive patients with relapsed or refractory hodgkin lymphoma: analysis of two phase I studies.

BACKGROUND Brentuximab vedotin is an antibody-drug conjugate designed to selectively deliver monomethyl auristatin E, a microtubule-disrupting agent, to CD30-expressing cells. Brentuximab vedotin induces durable objective responses in patients with relapsed or refractory Hodgkin lymphoma (HL) after autologous stem cell transplantation (ASCT). The objective of this post-hoc analysis was to characterize the safety and efficacy of brentuximab vedotin for patients with relapsed or refractory HL who refused or were ineligible for ASCT. METHODS This case series included 20 transplant-naïve patients who were enrolled in two phase I multicenter studies. Patients received brentuximab vedotin intravenously every 3 weeks or every week for 3 out of 4 weeks. RESULTS The majority of patients were transplant-naïve because of chemorefractory disease. Median age was 31.5 years (range, 12-87 years). Treatment-emergent adverse events in >20% of patients were peripheral neuropathy, fatigue, nausea, pyrexia, diarrhea, weight decreased, anemia, back pain, decreased appetite, night sweats, and vomiting; most events were grade 1 or 2. Six patients obtained objective responses: two complete remissions and four partial remissions. Median duration of response was not met; censored durations ranged from >6.8 to >13.8 months. Three of six responders subsequently received ASCT. CONCLUSION Brentuximab vedotin was associated with manageable adverse events in transplant-naïve patients with relapsed or refractory HL. The objective responses observed demonstrate that antitumor activity is not limited to patients who received brentuximab vedotin after ASCT. The promising activity observed in this population warrants further study.
Attitude and earth velocity estimation - Part I: Globally exponentially stable observer

The main contribution of this paper is the development of a novel attitude observer based on a triaxial high-grade rate gyro and single body-fixed vector measurements of a constant inertial vector, in contrast with typical solutions that require two of these vectors. The proposed structure consists in a cascade observer, where the angular velocity of the Earth around its own axis is extracted in the first block and the attitude is estimated in the second. The stability of the system as a whole is analyzed and the error dynamics are shown to be globally exponentially stable (GES). Simulation results are presented that illustrate the achievable performance of this solution. In a companion paper an alternative observer is proposed on the special orthogonal group and both solutions are compared.
WasTE COllECTION vEHIClE R OUTINg PROblEm: lITERaTURE REvIEW

Waste generation is an issue which has caused wide public concern in modern societies, not only for the quantitative rise of the amount of waste generated, but also for the increasing complexity of some products and components. Waste collection is a highly relevant activity in the reverse logistics system and how to collect waste in an efficient way is an area that needs to be improved. This paper analyzes the major contribution about Waste Collection Vehicle Routing Problem (WCVRP) in literature. Based on a classification of waste collection (residential, commercial and industrial), firstly the key findings for these three types of waste collec tion are presented. Therefore, according to the model (Node Routing Problems and Arc Routing problems) used to represent WCVRP, different methods and techniques are analyzed in this paper to solve WCVRP. This paper attempts to serve as a roadmap of research literature produced in the field of WCVRP.
Time-dependent toxicity of fluoranthene to freshwater invertebrates and the role of biotransformation on lethal body residues.

The time-dependent toxicity of fluoranthene was examined for Hyalella azteca, Chironomus tentans, and Diporeia spp. C. tentans appeared to be the most sensitive species, and Diporeia was the least sensitive. Incipient LC50 values, the concentration at which the LC50 reaches an asymptote and does not change with increasing duration of exposure, for H. azteca and C. tentans were approximately 60 and 40 microg x L(-1), respectively. Incipient levels were not reached for Diporeia; however, the 28-d LC50 concentration was 95.5 microg x L(-1). There was a temporal relationship with respect to lethal body residues for each of the test species. For H. azteca, the LR50, the median lethal residue at an identified exposure time required to cause 50% mortality, based on total fluoranthene equivalents (parent + metabolite compounds) decreased from 3.19 micromol x g(-1) at 5 d to 0.80 micromol x g(-1) at 28 d. For C. tentans, the LR50 decreased from 0.43 to 0.17 micromol x g(-1) from 2 to 10 d. The 10-d LR50 for Diporeia was 9.97 micromol x g(-1), and the 28-d value was 3.67 micromol x g(-1). The toxicokinetics are not sufficient to address the temporal changes in LR50 values. Thus, the data were fit to a Damage Assessment Model that also accounts for toxicodynamic processes. This analysis provides estimates of the incipient lethal residues for H. azteca, C. tentans, and Diporeia: 0.84, 0.21, and 3.00 micromol x g(-1), respectively. When comparing the relative sensitivity among species using lethal body residues, special attention should be given to ensure that comparisons are made at a common point in relation to exposure duration (i.e., time to steady state, Tss). When the LR50(lipid) values among the three species were compared at steady state, C. tentans is more sensitive than H. azteca and Diporeia spp. ; however, there are no significant differences between the amphipod species. The greater sensitivity of C. tentans to fluoranthene as compared to the amphipods may be due, in part, to a potential toxic metabolite.
Use of Sunscreen and Indoor Tanning Devices Among a Nationally Representative Sample of High School Students, 2001–2011

Adolescents are particularly vulnerable to engaging in poor skin-protection behaviors. The objective of this study was to examine use of sunscreen and indoor tanning devices among a nationally representative sample of high school students during a 10-year period (2001–2011) using data from the Youth Risk Behavior Surveillance System. The percentage of youth who reported using sunscreen declined from 67.7% in 2001 to 56.1% in 2011. The prevalence of using indoor tanning devices was highest among white females: 37.4% in 2009 and 29.3% in 2011. These findings indicate the need for prevention efforts aimed at adolescents to reduce risks for skin cancer.
MINTABS: early experiences with a new paradigm for programming SIMD computers

A programming paradigm for massively parallel SIMD computers is described. The paradigm requires that each program be compiled into a special instruction set. Initially, the MINTABS software architecture's instruction set is used. A process is assigned to a processing element (PE) by storing its instructions and data at that PE. The control unit broadcasts a fixed control algorithm and the PEs use it to interpret their own program. Initial experiments have demonstrated an increase in throughput by a factor of more than 700 on an 8192-processor machine. The throughput also increases linearly with the number of processors. <<ETX>>
Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion.

The localization of circulating leukocytes within inflamed tissues occurs as the result of interactions with and migration across vascular endothelium, and is governed, in part, by the expression of adhesion molecules on both cell types. Recently, we have described a novel primary adhesion interaction between the structurally activated form of the adhesion molecule CD44 on lymphocytes and its major ligand hyaluronan on endothelial cells under physiologic laminar flow conditions, and have proposed that this interaction functions in an extravasation pathway for lymphocytes in vascular beds at sites of inflammation. While the regulation of activated CD44 on leukocytes has been characterized in depth, regulation of hyaluronate (HA) on endothelial cells has not been extensively studied. Here we demonstrate that the expression of HA on cultured endothelial cell lines and primary endothelial cultures is inducible by the proinflammatory cytokines TNFalpha and IL-1beta, as well as bacterial lipopolysaccharide. In addition, this inducibility appears strikingly restricted to endothelial cells derived from microvascular, but not large vessel, sources. The elevated HA levels thus induced result in increased CD44-dependent adhesive interactions in both nonstatic shear and laminar flow adhesion assays. Changes in mRNA levels for the described HA synthetic and degradative enzymes were not found, suggesting other more complex mechanisms of regulation. Together, these data add to the selectin and immunoglobulin gene families a new inducible endothelial adhesive molecule, hyaluronan, and help to further our understanding of the potential physiologic roles of the CD44/HA interaction; i.e., local cytokine production within inflamed vascular beds may enhance surface hyaluronan expression on endothelial cells, thereby creating local sites receptive to the CD44/HA interaction and thus extravasation of inflammatory cells.
Temporal ictal electroencephalographic frequency correlates with hippocampal atrophy and sclerosis

We studied 328 complex partial seizures (CPS) in 63 consecutive patients with temporal lobe epilepsy who underwent scalp electroencephalography/video monitoring, magnetic resonance imaging (MRI), and surgery. The initial ictal discharge (IID), defined as the first sustained electrical seizure pattern localized to the surgical site, was determined. If the IID was rhythmic waves, the median frequency was measured. To determine if IID frequency correlates with hippocampal atrophy (HA) or sclerosis (HS), hippocampal volume ratios (HVRs) were measured (n = 52) or assessed visually (n = 11) on MRI, and mesial temporal histopathology specimens (n = 22) were graded for HS. Sixteen patients (25%) had no or mild HA (HVR = 0.78‐1.02), and 47 patients (75%) had moderate‐to‐marked unilateral (HVR = 0.33−0.76), or bilateral, HA. Theta frequency IIDs were significantly more commonly associated with moderate‐to‐marked HA than were delta IIDs. Theta frequency IIDs occurred in 19% of patients with mild or no HA, and 79% of patients with moderate‐to‐marked HA; delta IIDs occurred in 63% of patients with little to no HA, and 13% of those with moderate‐to‐marked HA. In addition, the median IId frequency inversely correlated with HVR and directly correlated with HS severity. In conclusion, faster frequency rhythmic IIDs during temporal lobe CPS correlate with greater degrees of ipsilateral HA on MRI, and higher grades of HS.
SYNTHES IS An evolutionary ecology of individual differences

Sasha R. X. Dall,* Alison M. Bell, Daniel I. Bolnick and Francis L. W. Ratnieks Abstract Individuals often differ in what they do. This has been recognised since antiquity. Nevertheless, the ecological and evolutionary significance of such variation is attracting widespread interest, which is burgeoning to an extent that is fragmenting the literature. As a first attempt at synthesis, we focus on individual differences in behaviour within populations that exceed the day-to-day variation in individual behaviour (i.e. behavioural specialisation). Indeed, the factors promoting ecologically relevant behavioural specialisation within natural populations are likely to have far-reaching ecological and evolutionary consequences. We discuss such individual differences from three distinct perspectives: individual niche specialisations, the division of labour within insect societies and animal personality variation. In the process, while recognising that each area has its own unique motivations, we identify a number of opportunities for productive ‘crossfertilisation’ among the (largely independent) bodies of work. We conclude that a complete understanding of evolutionarily and ecologically relevant individual differences must specify how ecological interactions impact the basic biological process (e.g. Darwinian selection, development and information processing) that underpin the organismal features determining behavioural specialisations. Moreover, there is likely to be covariation amongst behavioural specialisations. Thus, we sketch the key elements of a general framework for studying the evolutionary ecology of individual differences.
How plants LINC the SUN to KASH

Linkers of the nucleoskeleton to the cytoskeleton (LINC) complexes formed by SUN and KASH proteins are conserved eukaryotic protein complexes that bridge the nuclear envelope (NE) via protein-protein interactions in the NE lumen. Revealed by opisthokont studies, LINC complexes are key players in multiple cellular processes, such as nuclear and chromosomal positioning and nuclear shape determination, which in turn influence the generation of gametes and several aspects of development. Although comparable processes have long been known in plants, the first plant nuclear envelope bridging complexes were only recently identified. WPP domain-interacting proteins at the outer NE have little homology to known opisthokont KASH proteins, but form complexes with SUN proteins at the inner NE that have plant-specific properties and functions. In this review, we will address the importance of LINC complex-regulated processes, describe the plant NE bridging complexes and compare them to opisthokont LINC complexes.
Non-native species in the vascular flora of highlands and mountains of Iceland

The highlands and mountains of Iceland are one of the largest remaining wilderness areas in Europe. This study aimed to provide comprehensive and up-to-date data on non-native plant species in these areas and to answer the following questions: (1) How many non-native vascular plant species inhabit highland and mountainous environments in Iceland? (2) Do temporal trends in the immigration of alien species to Iceland differ between highland and lowland areas? (3) Does the incidence of alien species in the disturbed and undisturbed areas within Icelandic highlands differ? (4) Does the spread of non-native species in Iceland proceed from lowlands to highlands? and (5) Can we detect hot-spots in the distribution of non-native taxa within the highlands? Overall, 16 non-native vascular plant species were detected, including 11 casuals and 5 naturalized taxa (1 invasive). Results showed that temporal trends in alien species immigration to highland and lowland areas are similar, but it is clear that the process of colonization of highland areas is still in its initial phase. Non-native plants tended to occur close to man-made infrastructure and buildings including huts, shelters, roads etc. Analysis of spatio-temporal patterns showed that the spread within highland areas is a second step in non-native plant colonization in Iceland. Several statically significant hot spots of alien plant occurrences were identified using the Getis-Ord Gi* statistic and these were linked to human disturbance. This research suggests that human-mediated dispersal is the main driving force increasing the risk of invasion in Iceland’s highlands and mountain areas.
A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus Hemagglutinin

ABSTRACT The conserved influenza virus hemagglutinin (HA) stem domain elicits cross-reactive antibodies, but epitopes in the globular head typically elicit strain-specific responses because of the hypervariability of this region. We isolated human monoclonal antibody 5J8, which neutralized a broad spectrum of 20th century H1N1 viruses and the 2009 pandemic H1N1 virus. Fine mapping of the interaction unexpectedly revealed a novel epitope between the receptor-binding pocket and the Ca2 antigenic site on HA. This antibody exposes a new mechanism underlying broad immunity against H1N1 influenza viruses and identifies a conserved epitope that might be incorporated into engineered H1 virus vaccines.
Recent advances in the management of obstructive sleep apnea: The dental perspective

Obstructive sleep apnea (OSA) is common in adult population. OSA shows detrimental effects on health, neuropsychological development, quality-of-life, and economic potential and now it is recognized as a public health problem. Despite the availability of expanded therapeutic options, polysomnography and nasal continuous positive airway pressure (CPAP) are the gold standards for the diagnosis and treatment for OSA. Recently, American Academy of Sleep Medicine has recommended oral appliances for OSA. Hence the therapeutic interventions that are directed at the site of airway obstruction in the maxillofacial region are within the scope of dentistry. Treatment of OSA can improve vitality, social and daytime functioning, family life and mental health of a person and hence the quality-of-life. Obesity is the main predisposing factor for OSA. Other than obesity, craniofacial abnormalities such as micrognathia and retrognathia, age, ethnic background and genetic predisposition, consumption of alcohol, smoking, and sedatives may also predispose to OSA. Treatment modalities for OSA are behavior modification, diet and medication, CPAP devices, surgical (maxillo-mandibular advancement surgery), and oral appliances. Treatment of a patient with OSA not only improves the physical health of the patients but also the mental and social well-being.
La ricerca in psicoterapia: il contributo del Gruppo di lavoro della Cattedra di Psicologia Dinamica (base) della Seconda Universitdi Napoli

Lo scopo del presente lavoro e quello di illustrare i contributi passati e gli attuali interessi del Gruppo di ricerca della Cattedra di "Psicologia Dinamica" (corso di base) della Facolta di Psicologia della Seconda Universita di Napoli, nonche di presentare e argomentare le pubblicazioni scaturite negli ultimi anni dalle quelle ricerche. I lavori si inseriscono nelle aree relative alla Teoria dell'Attaccamento, alla valutazione psicologica, allo studio della psicopatologia connessa ai Disturbi del Comportamento Alimentare, alla ricerca in psicoterapia "single case".
Champagne , Elinor American cities : the CARMELA Study Educational inequalities in obesity , abdominal obesity , and metabolic syndrome in seven Latin

Aims: Earlier reviews have found that the proportion of inverse associations between socioeconomic status and obesity increased according to the level of development of the studied country. Based on this finding, it has been hypothesized that in lowto middleincome countries the burden of obesity shifts to disadvantaged groups as a country develops. Methods and results: CARMELA is a cross-sectional, population-based observational study that sampled 11,550 women and men age 25–64 from seven major Latin American cities. We analyzed by gender the association of educational attainments (as proxy of socioeconomic status) with body mass index, waist circumference and metabolic syndrome. Participating cities were divided by country Human Development Index (HDI). An inverse gradient between socioeconomic status and body mass index in women was uniformly present in High HDI cities (Buenos Aires, Santiago, Mexico) but not in Medium HDI group (Barquisimeto, Bogota, Lima, Quito), where two cities showed an inverse gradient and two cities did not. In men, no clear socioeconomic gradients were found. Findings regarding waist circumference and metabolic syndrome closely mirrored those about body mass index. Conclusion: In women but not men, these results give support to the hypothesis of obesity shifting to the poor and extend it to the related concepts of abdominal obesity and metabolic syndrome. Obesity should be considered as a socially-generated disease and an indicator of socioeconomic disadvantage, to be approached by comprehensive strategies that bear in mind this perspective.