Miracle-dz/UniFAR-FTUs huggingface dataset:
An Effective Model of CPU/GPU Collaborative Computing in GPU Clusters

Remote procedure call (RPC) is a simple, transparent and useful paradigm for providing communication between two processes across a network. The compute unified device architecture (CUDA) programming toolkit and runtime enhance the programmability of the graphics processing unit (GPU) and make GPU more versatile in high performance computing. The current researches mainly focus on the acceleration of algorithms on a GPU or multiple GPUs on a single host. This paper proposes a CPU/GPU collaborative model which can transparently use remote CPU/GPU computing resources to accelerate the computation. The objective is to efficiently manage CPU/GPU resources in a cluster to achieve load balancing.
Crystal Structure of Mycobacterium tuberculosis Zinc-dependent Metalloprotease-1 (Zmp1), a Metalloprotease Involved in Pathogenicity*

Mycobacterium tuberculosis, the causative agent of tuberculosis, parasitizes host macrophages. The resistance of the tubercle bacilli to the macrophage hostile environment relates to their ability to impair phagosome maturation and its fusion with the lysosome, thus preventing the formation of the phago-lysosome and eventually arresting the process of phagocytosis. The M. tuberculosis zinc-dependent metalloprotease Zmp1 has been proposed to play a key role in the process of phagosome maturation inhibition and emerged as an important player in pathogenesis. Here, we report the crystal structure of wild-type Zmp1 at 2.6 Å resolution in complex with the generic zinc metalloprotease inhibitor phosphoramidon, which we demonstrated to inhibit the enzyme potently. Our data represent the first structural characterization of a bacterial member of the zinc-dependent M13 endopeptidase family and revealed a significant degree of conservation with eukaryotic enzymes. However, structural comparison of the Zmp1-phosphoramidon complex with homologous human proteins neprilysin and endothelin-converting enzyme-1 revealed unique features of the Zmp1 active site to be exploited for the rational design of specific inhibitors that may prove useful as a pharmacological tool for better understanding Zmp1 biological function.
NMR Solution Structure of the Terminal Immunoglobulin-like Domain from the Leptospira Host-Interacting Outer Membrane Protein, LigB

A number of surface proteins specific to pathogenic strains of Leptospira have been identified. The Lig protein family has shown promise as a marker in typing leptospiral isolates for pathogenesis and as an antigen in vaccines. We used NMR spectroscopy to solve the solution structure of the twelfth immunoglobulin-like (Ig-like) repeat domain from LigB (LigB-12). The fold is similar to that of other bacterial Ig-like domains and comprised mainly of β-strands that form a β-sandwich based on a Greek-key folding arrangement. Based on sequence analysis and conservation of structurally important residues, homology models for the other LigB Ig-like domains were generated. The set of LigB models illustrates the electrostatic differences between the domains as well as the possible interactions between neighboring domains. Understanding the structure of the extracellular portion of LigB and related proteins is important for developing diagnostic methods and new therapeutics directed toward leptospirosis.
Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer.

CONTEXT Abiraterone acetate is a small-molecule cytochrome P450 17A1 (CYP17A1) inhibitor that is active in castration-resistant prostate cancer. OBJECTIVE Our objective was to determine the impact of abiraterone with and without dexamethasone treatment on in vivo steroidogenesis. DESIGN AND METHODS We treated 42 castrate, castration-resistant prostate cancer patients with continuous, daily abiraterone acetate and prospectively collected blood and urine before and during abiraterone treatment and after addition of dexamethasone 0.5 mg daily. RESULTS Treatment with single-agent abiraterone acetate was associated with accumulation of steroids with mineralocorticoid properties upstream of CYP17A1. This resulted in side effects, including hypertension, hypokalemia, and fluid overload, in 38 of 42 patients that were generally treated effectively with eplerenone. Importantly, serum and urinary androgens were suppressed by more than 90% from baseline. Urinary metabolites of 17-hydroxypregnenolone and 17-hydroxyprogesterone downstream of 17α-hydroxylase remained unchanged. However, 3α5α-17-hydroxypregnanolone, which can be converted via the backdoor pathway toward 5α-dihydrotestosterone, increased significantly and correlated with levels of the major 5α-dihydrotestosterone metabolite androsterone. In contrast, urinary metabolites of 11-deoxycortisol and active glucocorticoids declined significantly. Addition of dexamethasone to abiraterone acetate significantly suppressed ACTH and endogenous steroids, including 3α5α-17-hydroxypregnanolone. CONCLUSION CYP17A1 inhibition with abiraterone acetate is characterized by significant suppression of androgen and cortisol synthesis. The latter is associated with a rise in ACTH that causes raised mineralocorticoids, leading to side effects and incomplete 17α-hydroxylase inhibition. Concomitant inhibition of 17,20-lyase results in diversion of 17-hydroxyprogesterone metabolites toward androgen synthesis via the backdoor pathway. Addition of dexamethasone reverses toxicity and could further suppress androgens by preventing a rise in substrates of backdoor androgen synthesis.
Pattern Discovery in Time-Ordered Data

This report describes the results of a Laboratory-Directed Research and Development project on techniques for pattern discovery in discrete event time series data. In this project, we explored two different aspects of the pattern matching/discovery problem. The first aspect studied was the use of Dynamic Time Warping for pattern matching in continuous data. In essence, DTW is a technique for aligning time series along the time axis to optimize the similarity measure. The second aspect studied was techniques for discovering patterns in discrete event data. We developed a pattern discovery tool based on adaptations of the A-priori and GSP (Generalized Sequential Pattern mining) algorithms. We then used the tool on three different application areas--unattended monitoring system data from a storage magazine, computer network intrusion detection, and analysis of robot training data.
The Implications of Trade Barriers for Sectoral Diversification and Macroeconomic Stability in Developing Economies

The paper examines the implications of lower trade barriers for sectoral diversification and macroeconomic stability in developing economies with a large primary goods sector. It shows that lower trade barriers can have ambiguous effects on macroeconomic stability. It shows also that diversification, in the form of equal distribution of resources between nonprimary sectors, may be counterproductive. In fact, investment in the nonprimary sector with lower trade barriers unambiguously enhances macroeconomic stability in a developing economy that is subject to substantial primary shocks.
Antigen-Specific Immunoglobulin A Antibodies Secreted from Circulating B Cells Are an Effective Marker for Recent Local Immune Responses in Patients with Cholera: Comparison to Antibody-Secreting Cell Responses and Other Immunological Markers

ABSTRACT Gut-derived lymphocytes transiently migrate through the peripheral circulation before homing back to mucosal sites and can be detected using an ELISPOT-based antibody secreting cell (ASC) assay. Alternatively, transiently circulating lymphocytes may be cultured in vitro, and culture supernatants may be assayed for antigen-specific responses (antibody in lymphocyte supernatant [ALS] assay). The ALS assay has not been validated extensively in natural mucosal infection, nor has the ALS response been compared to the ASC assay and other cholera-specific immunological responses. Accordingly, we examined immune responses in 30 adult patients with acute cholera in Bangladesh, compared with 10 healthy controls, measuring ALS-immunoglobulin A (IgA), ASC-IgA, and serum and fecal IgA responses to two potent Vibrio cholerae immunogens, the nontoxic B subunit of cholera toxin (CtxB) and lipopolysaccharide (LPS) and a weaker V. cholerae immunogen, the mannose-sensitive hemagglutinin (MSHA). We found significant increases of anti-CtxB, anti-LPS, and anti-MSHA IgA in supernatants of lymphocytes cultured 7 days after onset of cholera using the ALS assay. We found that ALS and ASC responses correlated extremely well; both had comparable sensitivities as the vibriocidal responses, and both procedures were more sensitive than fecal IgA measurements. An advantage of the ALS assay for studying mucosal immune responses is the ability to freeze antibodies in supernatants for subsequent evaluation; like the ASC assay, the ALS assay can distinguish recent from remote mucosal infection, a distinction that may be difficult to make in endemic settings using other procedures.
Comparative study of feature extraction methods applied to partial discharge signals

This paper aims to provide comparative study of different feature extraction methods applied to partial discharge signals. It has been clearly shown in research literature that partial discharge signals generated from different PD sources can have different shapes. It is highly beneficial to separate and classify such different signals as different signal shapes can indicate different underlying physical mechanisms and states. Time and frequency localisation characteristics, discrete wavelet composition (DWT) and principal component analysis (PCA) are popular feature extraction techniques that have been widely applied to signal analysis. While these techniques have their own advantages and disadvantages, their efficiency can be domain dependent. In this paper, we applied all three techniques to PD pulse analysis in order to identify the most suitable method for the purpose of PD pulse separation and anomaly detection. The comparisons are based on case studies using real data collected on site. We will show that PCA outperforms the other two methods in terms of finding efficient features for pulse separation purpose.
A Low-Voltage Planar Power MOSFET With a Segmented JFET Region

A new low-voltage planar power MOSFET with a segmented junction field effect transistor (JFET) region is proposed and demonstrated in this paper. The segmented JFET region consists of alternating n- and p-regions formed by using ion implantation, and it is fully depleted before the drain-source breakdown voltage is reached to provide a high breakdown voltage. The new planar power MOSFET allows a smaller gate-drain overlap area, a shallower p-body, and a JFET region with a doping concentration higher than those of the conventional vertical double-diffused MOSFETs (VDMOSFETs). The new structure with a breakdown voltage of 34 V is fabricated by using a 0.5-mum technology and is compared with the conventional VDMOSFET. The gate-drain charge density and the figure-of-merit are improved by 51% and 48%, respectively. However, the specific on-resistance of the device is increased by 5% due to the smaller conducting area in the segmented JFET region. Simulation results show that the figure-of-merit of the new structure is very favorable compared to those of commercial devices at the same voltage rating.
Relaxin Binds to and Elicits a Response from Cells of the Human Monocytic Cell Line, THP-1*

Relaxin is a 6-kDa peptide of the insulin family that is present at increased levels in the circulation during pregnancy. Its functions at that time are thought to include maintenance of myometrial quiescence, regulation of plasma volume, and release of neuropeptides, such as oxytocin and vasopressin. The protein also promotes connective tissue remodeling, which allows cervical ripening and separation of the pelvic symphysis in various mammalian species. In this report, we provide evidence for a novel target of relaxin, the human monocytic cell line, THP-1. Relaxin bound with high affinity (Kd = 102 pM) to a specific receptor on THP-1 cells. Receptor density was low (∼275 receptors/cell), but binding of relaxin triggered intracelluar signaling events. Receptor density was not modulated by pretreatment with estrogen, progesterone, or a number of other agents known to induce differentiation of THP-1 cells. Cross-linking studies showed radiolabeled relaxin bound primarily to cell surface proteins with an apparent molecular mass of >200 kDa. Other members of the insulin-like family of proteins (insulin, insulin-like growth factors I and II, and relaxin-like factor) were unable to displace the binding of relaxin to THP-1 cells, suggesting that a distinct receptor for relaxin exists on this monocyte/macrophage cell line.
Relationship between winter orographic precipitation with synoptic and large-scale atmospheric circulation: The case of mount Olympus, Greece

The relationship between the winter (DJFM) precipitation and the atmospheric circulation patterns is examined around Mount Olympus, Greece in order to assess the effects of orography and atmospheric dynamics over a small (less than 100 x 100 km) spatial domain. Winter accumulated rainfall datasets from 8 stations spread along the eastern (marine) and western (continental) sides of the Mount Olympus at elevations between 30 m and 1150 m are used during the period 1981 to 2000. Synoptic scale conditions of mean sea-level pressure and geopotential heights at 850 hPa and 500 hPa, were used to explain the multiyear rainfall variability. High pressure systems dominated over the central Mediterranean and most parts of central Europe during the late 1980’s and early 1990’s, are associated with minimum winter rainfall along both sides of Mount Olympus. The winter of 1996 was associated with peak in rainfall along the marine side of the mountain and was characterized by enhancement of upper level trough over the western Mediterranean and increased low tropospheric depressions over the southern Adriatic and the Ionian Seas. This atmospheric circulation pattern facilitated a southeasterly air flow that affected more (less) the marine (continental) sides of the mountain. In contrast, dominance of low pressure systems with cores over the Gulf of Genoa and the Central Mediterranean affect the study area mostly from west/southwest revealing higher correlations with the precipitation in the continental side of the mountain (r= -0.80; Elassona station) and considerably lower correlations with the marine side (r = -0.67; Katerini station). This highlights the orographic barrier of the Mount Olympus revealing large differences between the upward and leeward sides. Large scale atmospheric patterns like the North Atlantic Oscillation and the Arctic Oscillation seem to influence the winter rainfall in the lowlands along the continental side of the mountain.
Méthodologie de design CEM - Couche équipement

L’objectif de cet article est de presenter un etat de l’art sur la methodologie de developpement CEM. Apres un rappel du cycle de developpement en V, nous decrivons les etapes de l’approche remontante qui vont permettre de justifier les specifications de design. Les regles de l’art permettent d’eviter les erreurs majeures de design, cependant les contraintes mecaniques, thermiques ou de placement rendent inapplicables certaines regles. Il faut donc specifiquement les adapter et les justifier par modelisation. La derniere etape du developpement est la redaction du Plan de Test qui va permettre de garantir la reproductibilite des resultats.
Severity of renal vascular disease predicts mortality in patients undergoing coronary angiography.

BACKGROUND Renal artery stenosis (RAS) is a relatively uncommon but potentially reversible cause of renal failure. In a previous report, we demonstrated that the presence of RAS is independently associated with mortality in a group of patients undergoing coronary angiography. Our current study expands on this cohort, investigating the effect of the severity of RAS on all-cause mortality. METHODS A total of 3987 patients underwent abdominal aortography immediately following coronary angiography. For the purpose of survival analysis, significant RAS was defined as > or =75% narrowing in the luminal diameter. RESULTS Significant RAS was present in 4.8% of patients studied and was bilateral in 0.8%. Factors associated with the presence of RAS included female gender, older age, hypertension, congestive heart failure, elevated serum creatinine, and congestive heart failure. The four-year unadjusted survivals for patients with and without significant RAS were 57 and 89%, respectively (P < 0.001). Using the Cox proportional hazards model, the factors independently associated with decreased survival were the presence of RAS, increased age, the severity of coronary artery disease, the presence of comorbid disease, reduced ejection fraction, symptoms of congestive cardiac failure, and the mode of treatment of coronary artery disease. In the multivariate model, the presence of RAS conferred a hazard ratio of 2.01 (95% CI, 1.51 to 2.67, P < 0.001). We demonstrated an incremental effect on mortality according to the severity of RAS at baseline. Four-year adjusted survival for patients with 50%, 75%, and > or =95% stenosis was 70%, 68%, and 48%, respectively. In addition, bilateral disease was associated with four-year survival of 47% as compared with 59% for patients with unilateral disease (P < 0.001). The impact of RAS on survival remained robust regardless of the manner of treatment of coronary artery disease [that is, medical, percutaneous transluminal coronary angioplasty (PTCA), or coronary artery bypass graft (CABG)]. CONCLUSIONS In this patient population, the presence of RAS is a strong independent predictor of mortality. Increasing severity of RAS has an incremental effect on survival probability.
Residues of gentamicin in eggs following medication of laying hens

1. Gentamicin was injected subcutaneously and intramuscularly into 5 groups of 10 laying hens and its concentration was determined in albumen, yolk and whole egg. 2. Groups 1 and 3 were intramuscularly injected with doses of 10 and 25 mg/kg while groups 2, 4 and 5 were subcutaneously injected with doses of 10, 25 and 50 mg/kg, respectively. 3. The final gentamicin concentration in albumen was measured on d 3 for groups 1 and 2; on d 4 for groups 3 and 4, and on d 5 for group 5. Concentrations in yolk and whole egg were measured on d 7, 10 and 12. 4. Gentamicin recovery was as follows: 2% in groups 1 and 2, 2·5% in groups 3 and 4, and 3% in group 5. 5. Most of the residue (∼90%) was recovered from the yolk.
Thermal aging effects on the moisture equilibrium curves of mineral and mixed oil-paper insulation systems

Moisture equilibrium curves are well accepted methods for moisture estimation of insulation paper in field transformers. The thermal aging effects on moisture partition diagrams of mineral oil-paper and a new aging-resistant mixed oil-paper insulation system were studied. The purpose was to assess the moisture content accurately, particularly in transformers used for long-term operations. Thermal aging experiment was conducted at 130 °C for 80 days, and moisture equilibrium curves at five different aging degrees and three different temperatures were constructed. Results showed that under the same oil moisture content, the moisture content in paper decreased as the aging condition aggravated. The mass fraction of moisture content in oil and paper was calculated at each aging degree. Comparative results revealed that the moisture absorption capacity of insulation paper had an age-related decreasing tendency, whereas the moisture absorption capacity of insulating oil had an age-related increasing tendency. Moisture partition diagrams of mineral and aging-resistant mixed oil-paper samples were compared. Results showed that with the same oil moisture concentration, the moisture of insulation paper impregnated in mixed oil was remarkably lower than that impregnated in mineral oil.
Passive antibody decay in rabbits under cold or altitude stress.

Rabbits maintained at an environmental temperature of -15℃ (5℉) for 10 weeks exhibit an increase in the decay rate of passively administered antibody. Rabbits acclimatized at an altitude of 12,470 feet for 30 days show little or no change in passive antibody decay. Protein turnover in these groups of animals is discussed. Submitted on October 27, 1958
Analog circuit design at and below VT + 2Vds,sat

Design methods and architectures for high-performance analog circuitry which operates at supply voltages at and below VT + 2 Vds,sat are developed. A low voltage amplifier is designed using these methods. The amplifier, fabricated in an AMIS 0.5 mum CMOS process with 0.8 V p-channel threshold voltages, is shown to operate at supply voltages as low as 0.75 V with full rail-to-rail input and output operation. The amplifier shows 105 dB of open loop gain and GBW of 0.31 MHz while dissipating 11.5 muW from a 0.8 V supply. The design methods may be used with advanced CMOS processes to further reduce the required analog supply voltage.
"The living end".

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Ciliary neurotrophic factor and phorbol ester each decrease selected STAT3 pools in neuroblastoma cells by proteasome-dependent mechanisms.

Many cytokines and growth factors activate common signal transduction pathways and yet are able to elicit distinct cell-specific responses. We are defining mechanisms regulating signalling molecules in order to understand how cytokines can produce unique responses. It was found that individual members of the signal transducer and activator of transcription (STAT) family are regulated by ciliary neurotrophic factor (CNTF) and by protein kinase C. Treatment of SH-SY5Y human neuroblastoma cells with the phorbol ester, 12- O -tetradecanoylphorbol 13-acetate (TPA), for 4-5 h caused a 60% decline in both STAT2 and STAT3 levels and no decline in levels of STATs 1, 5 or 6, or in Jaks 1 or 2. The decline in STAT3 was inhibited by treatment with MG132, an inhibitor of proteasome-dependent protein degradation. Treatment of cells with CNTF induced a rapid tyrosine phosphorylation of STAT3 followed by a time-dependent decay of this signal. Loss of tyrosine phosphorylated STAT3 was inhibited by MG132 but did not require protein kinase C activity. These results suggest that STAT3 availability can be controlled by proteasome-dependent pathways activated either by protein kinase C or by cytokines.
The p53 isoforms are differentially modified by Mdm2

The discovery that the single p53 gene encodes several different p53 protein isoforms has initiated a flurry of research into the function and regulation of these novel p53 proteins. Full-length p53 protein level is primarily regulated by the E3-ligase Mdm2, which promotes p53 ubiquitination and degradation. Here, we report that all of the novel p53 isoforms are ubiquitinated and degraded to varying degrees in an Mdm2-dependent and -independent manner, and that high-risk human papillomavirus can degrade some but not all of the novel isoforms, demonstrating that full-length p53 and the p53 isoforms are differentially regulated. In addition, we provide the first evidence that Mdm2 promotes the NEDDylation of p53β. Altogether, our data indicates that Mdm2 can distinguish between the p53 isoforms and modify them differently.