Miracle-dz/UniFAR-FTUs huggingface dataset:
Whole foods nutrition for enhanced injury prevention and healing

Copyright © 2016 American C INTRODUCTION fter an injury or surgery, one of the primary goals of all athletes is to be able to heal as quickly as possible and return to play. Trainers and coaches monA the athlete’s rehabilitation process and attempt to use themost effective modalities and resources available to them. In this process, nutrition often is an underutilized component. Many athletes use dietary supplements on a daily basis and have begun to associate nutrition with pills and powders instead of real food. One of the roles that health professionals can play is to guide athletes toward a return to whole foods. Whole foods offer the best nutrition, often at a better price than supplements, and include components that are not available in pills and powders, because of the synergistic value of whole foods. Postinjury or postsurgery is a critical time to get athletes eating better because this will aid in healing and enhance performance once they return to play.
PolyQ-independent toxicity associated with novel translational products from CAG repeat expansions

Expanded CAG nucleotide repeats are the underlying genetic cause of at least 14 incurable diseases, including Huntington’s disease (HD). The toxicity associated with many CAG repeat expansions is thought to be due to the translation of the CAG repeat to create a polyQ protein, which forms toxic oligomers and aggregates. However, recent studies show that HD CAG repeats undergo a non-canonical form of translation called Repeat-associated non-AUG dependent (RAN) translation. RAN translation of the CAG sense and CUG anti-sense RNAs produces six distinct repeat peptides: polyalanine (polyAla, from both CAG and CUG repeats), polyserine (polySer), polyleucine (polyLeu), polycysteine (polyCys), and polyglutamine (polyGln). The toxic potential of individual CAG-derived RAN polypeptides is not well understood. We developed pure C. elegans protein models for each CAG RAN polypeptide using codon-varied expression constructs that preserve RAN protein sequence but eliminate repetitive CAG/CUG RNA. While all RAN polypeptides formed aggregates, only polyLeu was consistently toxic across multiple cell types. In GABAergic neurons, which exhibit significant neurodegeneration in HD patients, codon-varied (Leu)38, but not (Gln)38, caused substantial neurodegeneration and motility defects. Our studies provide the first in vivo evaluation of CAG-derived RAN polypeptides and suggest that polyQ-independent mechanisms, such as RAN-translated polyLeu peptides, may have a significant pathological role in CAG repeat expansion disorders.
Stability of the inverse source problem for the Helmholtz equation in R3

We consider the reconstruction of a compactly supported source term in the constant-coefficient Helmholtz equation in R3, from the measurement of the outgoing solution at a source-enclosing sphere. The measurement is taken at a finite number of frequencies. We explicitly characterize certain finite-dimensional spaces of sources that can be stably reconstructed from such measurements. The characterization involves only the measurement frequencies and the problem geometry parameters. We derive a singular value decomposition of the measurement operator, and prove a lower bound for the spectral bandwidth of this operator. By relating the singular value decomposition and the eigenvalue problem for the Dirichlet–Laplacian on the source support, we devise a fast and stable numerical method for the source reconstruction. We do numerical experiments to validate the stability and efficiency of the numerical method.
Calves Productivity with Applying Integrated Village Management System (IVMS) and Rice-Straw Based Feed

The objective of the study was to assess the productivity of PO calves with Integrated Village Management System (IVMS). The calf management generally follows cow pattern. The IVMS management applied to calves include weaning 5-6 months and optimizing local feed. Straw-based cow feed with supplementation using greenfeed and concentrate. Recording productivity of calf include: birth, weaning, body weight, calf death calf mobilization. Weighing weight was done at birth, weaning, and every month in the first year of study and every 2 months in the next research year. Implementation of IVMS management with rice straw-based feed produces good PO calf productivity when supported by addition of other feed sources, i. e. feed with high protein composition (concentrate, legume) to balancing the nutrient composition of feed.
Aktivitas Sitotoksik pada Sel MCF-7 dari Tumbuhan Indonesia untuk Pengobatan Tradisional Kanker Payudara

Indonesia is rich in a variety of potential plants as research materials based on local wisdom in the discovery of new medicinal compound. The research results have been documented in the research office of plant and herbal medicine (Ristoja) 2012. This research is a further assessment of Ristoja 2012, aims to test the cytotoxic activity of 20 parts of plants that are used for traditional treatment of cancer in Indonesia. The extraction was carried out by the infuse method using water solvent then dried in 40 o C oven to obtain a dry extracts. The cytotoxicity activity test was performed on MCF-7 breast cancer cell model using MTT method, and cell profile with flow cytometry method. The results of cytotoxic test showed that 19 extracts had cytotoxic activity with IC 50 100-300 μg/ml. One plant showed strong activity i.e. Gerrardanthus macrorhizus Harv. ex Benth. & Hook.f. tuber with IC50 value 73.5 μg/mL. Root tuber extract did not affect the MCF-7 cell cycle profile but increased cell population in sub G1 indicating apoptosis induction, potentially developed as chemopreventive agent. Abstrak Indonesia kaya akan berbagai jenis tumbuhan yang potensial sebagai bahan riset berbasis kearifan lokal dalam penemuan senyawa baru berkhasiat obat. Kekayaan tersebut terhimpun dalam hasil penelitian riset tumbuhan dan jamu (Ristoja) tahun 2012. Penelitian ini merupakan analisis lanjut dari Ristoja 2012 yang bertujuan untuk menguji aktivitas sitotoksik 20 bagian tumbuhan yang dimanfaatkan untuk pengobatan tradisional kanker di Indonesia. Ekstraksi dilakukan dengan metode infusa menggunakan pelarut air kemudian dikeringkan dalam oven suhu 40 o C hingga diperoleh ekstrak kering. Uji aktivitas sitotoksik dilakukan pada model sel kanker payudara MCF-7 menggunakan metode MTT, dan profil siklus sel dengan metode flow cytometry . Hasil uji sitotoksik menunjukkan, 19 ekstrak memiliki aktivitas sitotoksik dengan IC 50 100-300 μg/mL. Satu tumbuhan menunjukkan aktivitas kuat yaitu umbi akar batu ( Gerrardanthus macrorhizus Harv. ex Benth. & Hook.f.) dengan nilai IC 50 73,5 μg/mL. Ekstrak umbi akar batu tidak mempengaruhi profil siklus sel MCF-7 namun meningkatkan populasi sel di sub G1 yang mengindikasikan terjadinya apoptosis, sehingga potensial dikembangkan sebagai agen kemopreventif.
Neuro-functional modeling of near-death experiences in contexts of altered states of consciousness

Near-death experiences (NDEs) including out-of-body experiences (OBEs) have been fascinating phenomena of perception both for affected persons and for communities in science and medicine. Modern progress in the recording of changing brain functions during the time between clinical death and brain death opened the perspective to address and understand the generation of NDEs in brain states of altered consciousness. Changes of consciousness can experimentally be induced in well-controlled clinical or laboratory settings. Reports of the persons having experienced the changes can inform about the similarity of the experiences with those from original NDEs. Thus, we collected neuro-functional models of NDEs including OBEs with experimental backgrounds of drug consumption, epilepsy, brain stimulation, and ischemic stress, and included so far largely unappreciated data from fighter pilot tests under gravitational stress generating cephalic nervous system ischemia. Since we found a large overlap of NDE themes or topics from original NDE reports with those from neuro-functional NDE models, we can state that, collectively, the models offer scientifically appropriate causal explanations for the occurrence of NDEs. The generation of OBEs, one of the NDE themes, can be localized in the temporo-parietal junction (TPJ) of the brain, a multimodal association area. The evaluated literature suggests that NDEs may emerge as hallucination-like phenomena from a brain in altered states of consciousness (ASCs).
Energy-Saving Measurement in LoRaWAN-Based Wireless Sensor Networks by Using Compressed Sensing

In modern monitoring systems, it is essential to deploy sensor nodes and deliver related data to the information center. Wireless sensor networks (WSNs) usually work in harsh environments with vibration, temperature variations, noise, humidity, and so on. The batteries of sensor nodes are always not replaceable because of difficult access. Most of existing literature tries to prolong network lifetime by improving sleep scheduling strategies and deployment methods, independently or jointly. However, the congenital defects of mesh network can’t be avoided completely. To overcome the technology challenges, this paper develops a LoRaWAN-based WSN and investigates its energy efficient scheduling method. Firstly, the basics and the limits of LoRaWAN are introduced and the feasibility and the considerations of LoRaWAN-based star wireless sensor network are discussed. Secondly, an improved compressed sensing algorithm named ISL0 (improved SL0) is proposed for network data reconstruction and compressed sensing algorithm can reduce the number of LoRa nodes transmitting data packets to avoid collision and latency. Thirdly, a sleep schedule method is proposed to reliably monitor environment data and device operating status. By using the proposed method, not only the abnormal information can be detected on time, but also the overall network data can be recorded termly. Simulation and measurement results verify all nodes have same power level at different times, and the network lifetime is maximized.
Intracellular function in rehydrated lyophilized platelets

This study aimed to evaluate the effect of cross‐linking and lyophilization on intracellular signalling processes in rehydrated, lyophilized (RL) platelets, which are under development as a platelet substitute for transfusion. Exposure of RL platelets to thrombin resulted in enhanced phosphorylation of several proteins, including 18 kDa and 42 kDa kinase substrates that were shown to be the substrates of myosin light chain and protein kinase C respectively. Cross‐linking and lyophilization depleted the platelets of free cytoplasmic ADP and ATP, but had less effect on protein‐bound nucleotides. The surface membrane of RL platelets was found to be permeable to poly dT probes less than approximately 3 kDa in size; larger nucleotide probes and proteins did not penetrate the surface membrane. Taken together, our results indicate that RL platelets retain some of the haemostatic stimulus‐response functions of fresh platelets and are capable of feedback amplification in coagulation.
Isolation and Molecular Identification of some Food Borne Pathogens from Raw and Processed Meats: In vitro Synergistic Probability of Lactobacillus CFS and Antibiotic

MICROBIAL food safety is an important health concern; isolation of food-borne pathogens from available meat products is a bad indicator of poor hygienic practices. A Total of 200 samples of meats comprise beef burger, sausage, raw chicken and raw red meat (50 of each) were examined for hygienic quality by detecting the presence of potential bacterial food-borne pathogens. The highest frequency was recorded for E. coli (48.25%) and Salmonella sp. (26.25%) for the different meat samples, at the same time chicken meat was the most contaminated type. Isolates were identified by conventional bacteriological methods and confirmed by polymerase chain reaction using specific 16S rRNA primer pairs. B. cereus was identified by targeting the presence of enterotoxin nhe A and B genes. Checking for the presence of shiga-toxin gene in E. coli O517 showed positive result. All confirmed isolates were tested for multidrug resistance characterization and found to be highly resistant to almost of the studied antibiotics. The most resistant strain was B. cereus (75%) and the less efficient antibiotics were ampicillin and Sulfamethaxole/trimethoprim. Lactobacillus acidophilus cell free supernatant (CFS) showed efficient activity to inhibit the growth of all resistant isolates. Synergistic activity was detected when both agents (ampicillin & CFR) were used in combination against S. aureus and P. aeruginosa.
El uso de las redes sociales para posicionar un destino turístico: el caso de la ciudad de Guararema y sus visitantes del día

Social networks have become an important tool for image formation and positioning of tourist destinations. The aim of this study is to understand the use of social networks for the positioning of a city using these means in the important segment of day visitors, i.e., those tourists who do not spend the night in the place visited. This is an exploratory and qualitative study, for which the municipality of Guararema, in São Paulo, Brazil, was chosen. Data triangulation was based on a) content analysis of 11 social network accounts, b) specialized journals, c) in-depth interviews with visitors; and d) content of the city’s website and tourism master plan. As a result, it turned out that in this destination there is a clear positioning for day visitors interested in natural landscapes and cuisine. Placement is consistent with images that are viewed on networks. Social networks and the press together tend to generate visits, generating a cycle. As a suggestion for future studies, we propose to understand this phenomenon in the low or high season and expand studies on day-visitors, still little studied in the literature. KEYWORD: social networks, city positioning, day visitors.
Simulation of the Structure of Bond Issuer’s Obligations Fulfillment: A Case of Sub-Federal Bonds

Depreciable bonds issues can significantly expand the issuers’ abilities to manage public debt. The purpose of the study is to suggest possible options for a model for fulfilling obligations by issuers of depreciable sub-federal bonds. The study was conducted using a discrete grouping constructed according to the criterion of the bonds face value repayment number. We propose a set of indicators to assess the issuers’ possibilities to place depreciable sub-federal bonds in the Russian market. Our analyses showed that, during the period under review, the probability of successful depreciable bond issues placement in the sub-federal segment remained at a high level for bond issues with a nominal value of no more than 30.0 billion rubles and a maturity of no more than 3650 days. Deterioration of the bond market environment did not lead to significant changes in the structure of the bond issuers’ obligations fulfillment. The most common was a model involving four repayments of the depreciable bonds nominal value.
High-Temperature Nano-Indentation Creep Behavior of Multi-Principal Element Alloys under Static and Dynamic Loads

Creep is a serious concern reducing the efficiency and service life of components in various structural applications. Multi-principal element alloys are attractive as a new generation of structural materials due to their desirable elevated temperature mechanical properties. Here, time-dependent plastic deformation behavior of two multi-principal element alloys, CoCrNi and CoCrFeMnNi, was investigated using nano-indentation technique over the temperature range of 298 K to 573 K under static and dynamic loads with applied load up to 1000 mN. The stress exponent was determined to be in the range of 15 to 135 indicating dislocation creep as the dominant mechanism. The activation volume was ~25b3 for both CoCrNi and CoCrFeMnNi alloys, which is in the range indicating dislocation glide. The stress exponent increased with increasing indentation depth due to higher density and entanglement of dislocations, and decreased with increasing temperature owing to thermally activated dislocations. The results for the two multi-principal element alloys were compared with pure Ni. CoCrNi showed the smallest creep displacement and the highest activation energy among the three systems studied indicating its superior creep resistance.
Relationship between the levels of volatile sulfur compounds with the levels of RANKL and OPG in patients with moderate or severe periodontitis: A cross sectional study

Background: The effect of the Volatile Sulfur Compounds (VSC) on the periodontal tissues, specifically at the RANKL/OPG level has not been elucidate and there is little literature published on this subject. Aim: To explore if the VSC levels measured in the oral cavity of patients with moderate or severe chronic periodontitis are correlated with the expression of RANKL and OPG at the gingival fluid level (GF). Method: A crosssectional study was conducted with 71 patients referred by the Universidad de los Andes’s dentistry diagnosis department. After undergoing fullmouth periodontal exam, levels of CVS were recorded using a sulfur monitor and then GF was extracted to assess RANKL and OPG levels with ELISA. Data was analyzed with Spearman correlation test. Results: The correlation (R) between the VSC and the GF levels was 0.098 with a p value = 0.41; -0.084 with a p value = 0.48 y 0.067 with a p value = 0.57 respectively. Conclusions: This study could not demonstrate if there is a relation between the VSC levels and the expression of RANKL and OPG in the GF in patients with chronic periodontitis. Rev. Clin. Periodoncia Implantol. Rehabil. Oral Vol. 6(1); 20-24, 2013.
Consumer price index prediction using Long Short Term Memory (LSTM) based cloud computing

Long Short Term Memory (LSTM) is known as optimized Recurrent Neural Network (RNN) architectures that overcome the lack of RNN’s about maintaining long period of memories information. As part of machine learning networks, LSTM also notable as the right choice for time-series prediction. Inflation rate has been used for decision making for central banks also private sector. In Indonesia, CPI (Consumer Price Index) is one of best practice inflation indicators besides Wholesale Price Index and The Gross Domestic Product (GDP). Since CPI data could be used as a direction for next inflation move, we conducted CPI prediction model using Long Short Term Memory Method. The network model input consists of 34 variables of staple price in Surabaya and the output is CPI value. In the interest of predictive accuracy improvement, we used several optimization algorithm i.e. Stochastic Gradient Descent (sgd), Root Mean Square Propagation (RMSProp), Adaptive Gradient (AdaGrad), Adaptive moment (Adam), Adadelta, Nesterov Adam (Nadam) and Adamax. The result indicate that Nesterov Adam has 4.088 RMSE’s value, less than other algorithm which indicate the most accurate optimization algorithm to predict CPI value.
The National Audit of Cardiac Rehabilitation : Annual Statistical Report 2016

All rights reserved. No part of this publication may be reproduced or transmitted, in any form or by any means, electronic, photocopying or otherwise without prior permission of the publishers. NHS workers and teachers may make photocopies for education purposes only, provided that no charge or profit is made for any course or event for which they are used. 1 ACKNOWLEDGEMENTS The National Audit of Cardiac Rehabilitation (NACR) is a British Heart Foundation (BHF) project which aims to ensure that patients with cardiovascular disease achieve the best possible outcomes following a cardiac event. The NACR has supported over 300 programmes to enter clinical data for over 75,000 patients in the last year alone. The National Audit team is grateful for the continued support from the BHF and welcomes their new strategy which reaffirms its commitment to supporting the NHS to deliver high-quality services aimed at optimising outcome for people with cardiovascular disease. The British Association for Cardiovascular Prevention and Rehabilitation (BACPR) is a formidable ally with a shared ambition to ensure that all CR programmes in the UK are, at the very least, carried out to a basic minimum standard that is known to benefit patients. We look forward to working even closer with the BACPR and its members as part of our collaborative national certification programme. Thanks also to the Health and Social Care Information Centre (HSCIC) team for their support and expertise in redesigning the audit and supporting the NACR to achieve high quality data governance. The HSCIC shares our desire to use audit data to reduce inequalities and improve services for the betterment of patients. The National Audit team would like to thank patients for agreeing to take part in the audit and for completing the clinical assessments and questionnaires before and after their programme. Our gratitude extends to the 300 plus cardiac rehabilitation (CR) teams who, in collaboration with patients and carers, have helped over 600 patients to stop smoking, improved risk factor management, increased exercise frequency and improved psychosocial well-being for tens of thousands of patients in the last 12 months. We would very much like to thank the NACR Steering Committee for their continued support and expertise in shaping recent developments. They are:
Nurses assessment of symptoms in cancer patients

Introduction: One of the leading health problems in the female population is cancer of gynecological organs. The illness and medical treatment modalities cause many physical and / or psychological symptoms that have a negative impact on recovery and are an obstacle to the continuation of the expected functioning in both the daily and professional environments. Aim: To determine the prevalence of the most common physical and psychological symptoms in the patient population with gynecological carcinoma after surgery in relation to the localization of malignant tumors. Material and methods: The research was conducted according to the type of cross section study by interviewing patients suffering from gynecological carcinoma at the Institute for Oncology of Vojvodina in Sremska Kamenica, at the Clinic for operative oncology, Department of Gynecology in the period from December 2017 to February 2018. A brief version of the Symptom Assessment Scale - Short Form [MSAS-SF. ] Was used to assess the symptoms. Data processing included methods of descriptive and inferential statistics, for the data analysis, the statistical package SPSS 21 for Windows was used. Results: The average values of all supplements are the highest in the group of subjects with ovarian cancer. The highest mean value had a Global Distress Indicator. The total MSAS score indicates that psychological symptoms are dominant in relation to physical symptoms, for example, in divorced women with a secondary education level. The lack of energy and concern were the most common symptoms regardless of the localization of the carcinoma. Conclusion: The results of the study indicate that patients with gynecologic and gynecologic cancer patients show a higher proportion of psychological symptoms than physical ones. In the domain of psychological symptoms, concern had the highest incidence, while in the supplements of physical symptoms the lack of energy was highlighted. Physical and psychological symptoms are most common in divorced women with secondary education.