Miracle-dz/UniFAR-FTUs huggingface dataset:
Establishing a Community Response

Too often the burden of responsibility falls solely upon the shoulders of the school when responding to a suicide crisis situation. While it is critical for the school to have procedures in place for responding to a crisis and for educating staff on how to respond effectively to a suicidal crisis, schools may find it extremely helpful and more effective to share the responsibility for successful and comprehensive intervention with the community (5, 6, 7, 8). The organized efforts of a community are the foundation of a public health approach. Schools are an integral partner in a public health approach for any area focused on children and youth.
Wisconsin Card Sorting Test Performance in Mesial Temporal Lobe Epilepsy

Purpose:To investigate the origin of frontal lobe dysfunction identified by the Wisconsin Card Sorting Test (WCST) in mesial temporal lobe epilepsy (MTLE). Methods:We included 85 patients with unilateral MTLE and 34 patients with neocortical temporal lobe epilepsy (NTLE). We included only MTLE patients who postoperatively became seizure free at least for 1 year. Comparisons were made on the WCST performance between MTLE and NTLE and between preoperative and postoperative test in MTLE. Standardized regression based (SRB) methodology was used for correcting test-retest bias. Results:1) There were no significant differences in frontal lobe dysfunction defined as more than 17 perseverative errors between MTLE (64%) and NTLE (76%). 2) No significant differences in WCST performance between MTLE and NTLE were noted, except in categories completed (p=0.05). NTLE achieved significantly fewer categories than MTLE. 3) The proportions of patients with MTLE who postoperatively showed a clinically meaningful improvement on WCST performance were higher than those who displayed a significant decline. In case of perseverative responses, 52% of patients with MTLE postoperatively showed an improvement whereas 18% displayed a decline. 4) Postoperatively, mean values of perseverative responses and total errors were significantly decreased (p<0.05). 5) Significant negative correlations were found between preoperative WCST performance and postoperative SRB change scores for WCST (r=-0.3~-0.4, p<0.05). Conclusions:Our results could not be explained by any one of ‘neural noise’ or ‘hippocampal’ hypothesis. Our data suggest that poor WCST performance in patients with MTLE might be attributed to dysfunction of neural system including both hippocampus and frontal lobe cortex. Further studies are needed to make new hypothesis. (J Korean Epilep Soc 2003;7(1):27-32)
Global Profiling Of Outcome Associated Alternative Splicing Events and Gene Expression In Diffuse Large B-Cell Lymphoma

Background Alternative splicing (AS) increases dramatically the diversity of the proteome by allowing a single gene to generate multiple transcripts and functionally diverse protein isoforms. Although previous studies have provided evidence that AS is often deregulated in cancers, the role of AS events in diffuse large B-cell lymphoma (DLBCL) remains largely unexplored. Here, we design and apply a novel method to analyze the global prognostically significant mRNA and AS variation by comparing differentially expressed exons and splicing variants between diffuse large B-cell lymphoma (DLBCL) patients, who have relapsed (poor prognosis group) or remained in remission (good prognosis group) after chemoimmunotherapy. Design and methods We performed genome-wide exon array analysis on RNAs isolated from 38 tumor tissues from young ( 1) disease. The patients were treated in a Nordic phase II protocol with six courses of R-CHOEP-14 followed by systemic central nervous system prophylaxis with one course of high dose methotrexate and high dose cytarabine. At the time of the analysis, median follow up was 50 months, predicted 5-year progression free survival (PFS) 74% and overall survival (OS) 75%. To identify genes with differential expression or with differential splicing between patients with poor or good prognosis, a novel algorithm based on a splicing index was developed. Results With a criteria of p Conclusions AS index is a more potential discriminator than conventional gene profiling between good and bad prognosis patients in DLBCL, and may provide a new class of cancer biomarker candidates. Disclosures: No relevant conflicts of interest to declare.
Acute Kidney Injury Sequel to Aspirin Induced Intestinal Obstruction

Self medication is common, though the harmful effects are usually not overt. In some cases the effects are many, serious and could be quite fatal. NSAIDS are drugs that are usually abused and their use, if contrary to instructions results in conditions that if care is not taken would not be only result in hospital attendance but also require some ivasive or surgical resolution. A classical example is the indiscriminate use of aspirin which would not only inflame the bowels but will also bring about bowel obstruction. With the adoption of a careful clinical appraisal and a choice of conservative treatment, an intestinal obstruction could be resolved thereby minimizing the possibility of re-admission as cases of abdominal surgical intervention are associated with increased risk of relapse.
Rapid Health and Equality Impact Assessment (HEqIA)of Mersey Care NHS Trust’s Outline Business Case for Mental Health and Learning Disability Services

The aim of this assessment is to look at the health and equality impacts of Mersey Care's Outline Business Case which aims to: Establish home treatment as the norm; Refocusing in-patient services around patients who are acutely ill with shorter lengths of stay; Developing a local Psychiatric intensive Care in-patient Unit (PICU); Strengthen community and primary care services. The results of this Health and Equality Impact Assessment will be used to feed the Outline Business Case
Final Results of a Phase I Study of the Anti-CD79b Antibody-Drug Conjugate DCDS4501A (Polatuzumab Vedotin) in Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma 4400

M.C. Palanca-Wessels,1 G. Salles,2 M. Czuczman,3 S. Assouline,4 I. Flinn,5 L.H. Sehn,6 M. Patel,7 R. Sangha,8 H. Tilly,9 R. Advani,10 O. Casasnovas,11 O. Press,1 S. Yalamanchili,12 R. Kahn,12 D. Lu,12 A. Chai,12 Y. -W. Chu,12 F. Morschhauser13 1Fred Hutchinson Cancer Research Center, Seattle, WA; 2Hospices Civils de Lyon, Pierre Benite, France; 3Roswell Park Cancer Institute, Buffalo, NY; 4Jewish General Hospital, Montreal, Canada; 5Sarah Cannon Research Institute and Tennessee Oncology, Nashville, TN; 6BC Cancer Agency, Centre for Lymphoid Cancer, Vancouver, Canada; 7Sarah Cannon Research Institute and Florida Cancer Specialists, Sarasota, FL; 8Cross Cancer Institute, Edmonton, Canada; 9Hematology, Centre Henri Becquerel, Rouen, France; 10Stanford Cancer Center, Stanford, CA; 11Hematology, CHU Dijon, Dijon, France; 12Genentech, Inc., South San Francisco, CA; 13CHU Claude Huriez, Lille Cedex, France
The influence of the levels of personality traits on the quality of life of latereproductive age women

Wstęp. coraz częściej dostrzega się istotny wpływ cech osobowości na wiele aspektów życia, w tym utrzymanie lub przywrócenie zdrowia. Zdrowie jest istotnym elementem jakości życia. Zatem na jakość życia w znacznym stopniu może wpływać osobowość jednostki. Cel pracy. ocena wpływu nasilenia cech osobowościowych na jakość życia kobiet w późnym okresie reprodukcyjnym. Materiał i metody. badaniami objęto 345 kobiet zdrowych, w późnym wieku reprodukcyjnym według standaryzowanej klasyfikacji straW. były to kobiety w wieku 42,3 ± 4,5 lat mieszkające w województwie zachodniopomorskim. Do pomiaru cech osobowości użyto inwentarza osobowości nEo–FFi costy i Mccrae w polskiej adaptacji Zawadzkiego, strelaua, szczepaniak i Śliwińskej, natomiast do oceny jakości życia zastosowano kwestionariusz sF-36 (Short Form Health Survey). Wyniki. najbardziej nasiloną cechą osobowości wśród badanych kobiet była otwartość na doświadczenie, w następnej kolejności ugodowość. badane kobiety najlepiej oceniły swoje funkcjonowanie fizyczne, emocjonalne oraz swoją sprawność fizyczną. W badanej grupie takie cechy jak: neurotyczność, ekstrawersja, sumienność, ugodowość i otwartość, korelują z większością wskaźników jakości życia. Wnioski. 1. Jakość życia zależna od zdrowia jest kształtowana przez cechy osobowościowe, które są względnie stabilne przez całe życie kobiety. 2. Wysoki poziom neurotyczności wpływa znacząco na pogorszenie jakości życia. 3. Świadomość wpływu nasilenia cech osobowości na jakość życia kobiet pozwoli optymalizować lekarzowi rodzinnemu działania diagnostyczo-terapeutyczne. Słowa kluczowe: cechy osobowości, jakość życia, kobiety
Validation of the device for evaluation of muscular strength in the cervical spine region

Abstract Background: In the physiotherapeutic practice, the need for measurements of e.g. range of motion or strength of the cervical spine muscles results from a variety of degenerative processes in the area of the head, cervical spine and shoulder girdle. In Poland, we designed a measurement stand based on the equipment described in foreign literature. Validation of the measurement stand was performed in order to determine the usefulness of this stand for measurements of maximal strength and muscle torques for the isometric contraction of the cervical spine muscles. Material/Methods: A group of 13 women was examined to validate the device. The criteria for inclusion into the study group were adult age, no back pain and head pain syndromes. Validation of the equipment consisted in the calculation of the intraclass correlation coefficient (ICC). Three measurements were performed for each movement in three planes: initial measurement (I), second measurement after 15 minutes (II) and the third measurement after a week (III). The ICC coefficient was calculated based on the methodology discussed in the study by Shrout and Fleiss (1979). Results: The results of the measurements reached the "excellent" level of the ICC coefficient between the first and the second test. In the case of the first and the third tests, the ICC coefficient reached the "good" level for the movements in the sagittal and transverse planes and the "excellent" level for the movements in the frontal plane. Conclusions: The measurement system used in the measurement stand designed by the authors of the present study can be successfully used for comparative studies of several groups or repeated examinations of the same study group after application of a specific therapeutic procedure.The stand cannot be used for evaluation whether the results obtained are consistent with the standards for specific populations or for comparison with the results obtained from other devices.
Central nervous system manifestations of multiple myeloma: risk and prognostic considerations

M ultiple myeloma accounts for about 1% of all cancers and for 10% of hematologic malignancies in the United States. e incidence rate ranges from 4-5 per 100,000 population. It is characterized by the neoplastic proliferation of a clone of plasma cells that produces monoclonal immunoglobulin and presents as focal or disseminated plasma cell dyscrasia. is clone of plasma cells usually multiplies in the bone marrow and often results in end-organ damage including anemia, osteolytic lesions, hypercalcemia, and abnormal kidney function. e involvement of the central nervous system (CNS) in multiple myeloma is uncommon, but can present at initial diagnosis or later in the course of the disease. More common causes of neurological symptoms in multiple myeloma include hypercalcemia, uremia, spinal cord or nerve root compression, and peripheral neuropathies. Risk factors linked to the development of CNS disease include unfavorable cytogenetics, heavy tumor burden, plasmablastic morphology, and extramedullary disease. In this report, we describe 2 patients who developed CNS involvement after autologous stem cell transplant (ASCT) in the context of extramedullary disease.
A Randomized Comparison of Total-Marrow Irradiation, Busulfan and Cyclophosphamide with Tandem High-Dose Melphalan in Patients with Multiple Myeloma.

Background Myeloablative chemotherapy with support of autologous peripheral blood stem cells (APBSC) has widely been accepted as a standard of care in patients (pts) with newly diagnosed multiple myeloma (MM). High-dose (HD) melphalan (Mel) 200 mg/m 2 was considered superior to total-body irradiaton (TBI) plus Mel 140 mg/m 2 for toxicity reasons. Since MM plasma cells are inherently responsive to irradiation, our group evaluated TBI aimed at reduced organ toxicity by shielding lungs and liver (total-marrow irradiation [TMI], 9 Gy) combined with busulfan (Bu, 12 mg/kg) and cyclophosphamide (Cy, 120 mg/kg) in a previous phase I/II trial (Einsele et al, Bone Marrow Transplant, 2003). Patients and methods In the current study (DSMM I), subjects with previously untreated MM in Durie-Salmon stages II/III were randomly assigned to either receive one course of TMI/Bu/Cy versus two cycles of HD Mel 200 mg/m 2 each with APBSC transplantation if having had an adequate number of stem cells collected and at least stable disease. Primary end point was event-free survival (EFS), secondary end points overall (OS) and disease-free survival (DFS). Results A total of 294 pts (median age, 54 years), 246 of whom completed stem cell harvest were enrolled between 8/1998 and 1/2002 by 46 centres. Eventually, 198 (n=100 TMI/Bu/Cy and n=98 HD Mel) pts were randomized and included into the ITT population. The safety population (n=80 TMI and n=118 HD Mel, due to 18 pts switching to Mel) was analyzed for toxicity and response. CR rate before HD therapy was 7.0% (7/100) in the TMI and 6.1% (6/98) in the Mel arm respectively. Significantly more pts receiving TMI/Bu/Cy experienced WHO grades 3 and 4 pulmonary and gastrointestinal toxicity and pain. Following HDT, CR rate increased to 17.5% (14/80, TMI) and 32.2% (38/118, HD Mel; p=.022) respectively. After a median follow-up of 1447 days, median EFS in the TMI group was 1161 days versus 1090 days for HD Mel (p=.812). Probability of 4-year OS was 72.7% (95%-CI: 62.1–80.7) with TMI and also 72.7% (95%-CI: 61.7–81.1) after HD Mel (p=.754). For pts in CR following HD therapy, probability of 4 year DFS was 62.4% (95%-CI: 33.6–81.6) for TMI vs. 50.4% (95%-CI: 30.6–67.3) for HD-Mel (p=.138). Conclusion In this randomized trial on pts with newly diagnosed MM, the irradiation-based regimen was associated with more pulmonary and GI toxicity when compared to HD Mel. Incidences of other toxicities including hepatotoxicity, however, were not different between the two treatment arms. CR rate was superior for HD-Mel, while there was no difference in OS and EFS between the two treatment arms. Subjects achieving CR may be more likely to enjoy prolonged DFS after TMI/Bu/Cy.
Metabolic outcomes of islet transplantation and correlation of graft function with hepatic imaging and immune response

s, posters and oral presentations ‘The impact of de novo Donor Specific Antibody development on 12 month graft outcome after islet transplantation. ’ Brooks AMS, Carter V, Marshall H, Aldibbiat A, Wardle J, Sheerin N, Manas DM, White SA, Shaw JAM. Published abstract and poster presentation at British Transplant Society Annual Professional Conference (March 2013). ‘Quantification of hepatic steatosis before and after intraportal pancreatic islet transplantation. ’ Ahmmed A, Brooks AMS, Hollingsworth KG, Trenell M, Choudhary P, Amiel SA, Huang GC, Rosenthal M, Forbes S, Rutter MK, Taylor R, Shaw JAM. Published Abstract, Poster 102, Brief Oral Presentation. Shortlisted for the Lilly Diabetes Clinical Science Poster Award. Diabetes UK Annual Professional Conference (March 2013).
Cardiovascular disease beyond traditional risk factors; balancing lipids and inflammation

In this thesis we aim to identify subjects at increased cardiovascular disease risk, not recognized or optimally treated by current guidelines. Part one of this thesis concerns lipids: we assess the inflammatory potential of LDL cholesterol, and the effects of available potent LDL lowering therapies hereon. The need for and timing of treatment of other hyperlipidemias remains elusive. Remnant cholesterol has been identified as an independent risk factor for cardiovascular disease. We assess its clearance by the liver and its relation with apo-CIII levels, and show that this lipid moiety influences several inflammatory pathways. In the second part of this thesis we investigate non-lipid driven diseases that predispose to cardiovascular risk, in which guidelines are scarce and interpretation may be difficult. Using ¹⁸F-FDG PET/CT we find increased arterial inflammation in common chronic inflammatory diseases (rheumatoid arthritis and ankylosing spondylitis). We assess the influence of anti-inflammatory treatment hereon and potential treatment with statins. We also find increased arterial inflammation in subjects suffering from Chronic Kidney Disease or diabetes, both associated with high CVD risk. The level of arterial inflammation is largely independent of traditional risk factors and driven by measures of disease regulation, highlighting the need for additional screening and treatment options. Although lowering of the inflammation is likely to improve cardiovascular outcomes, reduced immune responses carry increased risk of infection. Future therapies may also aim at enhancing anti-inflammatory pathways. In the final chapter of this thesis, we assess the potential of enhancing anti-inflammatory B cells on the progression of atherosclerosis.
Biomechanical regulation of permeability in Schlemm's canal endothelium with respect to glaucoma

Glaucoma is the leading cause of irreversible blindness worldwide and is associated with elevated intraocular pressure caused by increased aqueous humor outflow resistance. The majority of outflow resistance is located near the inner wall endothelium of Schlemm’s canal (SC) where aqueous humor passes through micron-sized pores to cross the endothelium. The basal-toapical direction of aqueous humor filtration pushes SC cells away from their supporting basement membrane, imposing large biomechanical strain on them and leading to the formation of domeshaped cellular outpouchings known as giant vacuoles (GVs). Our overarching hypothesis is that the demanding biomechanical environment of the inner wall provides local cues that regulate pore formation and filtration across SC endothelium. Four studies examined this hypothesis. The first study demonstrated that pore density increases with biomechanical strain applied to SC cells cultured on elastomeric membranes. The second study demonstrated that inner wall pores co-localise with regions of greater filtration across the inner wall. The third study developed a fluorescent assay to investigate pore formation in cultured SC cells, and experiments using this assay indicated that glaucomatous SC cells may have impaired pore-forming ability in response to strain. The fourth study examined the cytoskeleton and three-dimensional ultrastructure of the inner wall and showed that vimentin intermediate filaments colocalize with GVs, possibly providing internal support to allow inner wall cells to withstand the demanding mechanical environment of the inner wall. Taken together, these studies reveal that pore formation is a mechanosensitive process that allows the inner wall to function as a self-regulating filter by modulating its own porosity in response to local biomechanical cues arising from basal-to-apical filtration across the endothelium. This process appears altered in glaucoma, contributing to impaired pore formation and elevated outflow resistance characteristic of the disease. Pores and intermediate filaments are therefore potential targets for future glaucoma therapies.
The gut and oral microbiome in HIV disease: Workshop B1

Recent years have seen a massive expansion in our understanding of how we interact with our 13 microbial colonists. The development of new, rapid sequencing techniques such as pyrosequencing 14 and other next-generation sequencing systems have enabled us to begin to characterize the 15 constituents of our diverse microbial communities, revealing the astonishing genetic richness that is 16 our microbiome. Despite this, our ignorance of how these communities change over the course of an 17 HIV infection is profound. Whilst some steps have been made to characterize the HIV microbiome at 18 selected sites, these reports are still limited and much remains to be done. It has become apparent, 19 however, that host-microbiota interactions are perturbed during HIV infections, with microbial 20 translocation of potential pathogens linked to a variety of different HIV complications, including 21 more rapid progression of disease. The use of probiotics and prebiotics has been investigated as 22 treatments to alleviate symptoms for a variety of conditions, and is now being proposed for the 23 treatment of symptoms associated with HIV. However, this is a new area of investigations and many 24 questions remain unanswered. What we know about both of these topics is a drop in the ocean 25 compared with what we need to know. In this article, we report on a workshop where these two 26 major under-investigated research areas were presented, and future directions explored and 27 discussed. 28
Influence of dry herbal extracts on pentylenetetrazole-induced seizures in mice: screening results and relationship “chemical composition – pharmacological effect”

Aim. Screening of 48 dry extracts of plants belonging to 18 species of 8 families not studied before on anticonvulsant activity, to analyze the chemical composition for the extracts with proved anti- and proconvulsant activity, and to estimate the connection of the effect of herbal products and their phytochemical composition.Methods. On the model of pentylenetetrazole-induced seizures in mice the influence of 48 dry herbal extracts with varied chemical composition has been investigated. Extracts were standardized by the content of alkaloids, flavonoids and polyphenols according to European Pharmacopoeia methods (HPTLC, HPLC, UPLC, GC-MS). Results. By the integral indicator of efficacy – reduction of the mortality rate – it has been found that 11 of herbal preparations have significant anticonvulsant properties, 10 extracts act as proconvulsants, and the remaining 27 extracts have practically no effect on experimental convulsions. It has been established that there is a relationship between the pharmacological effect of preparations and phytochemical composition of the plant being extracted as well as the host species (for parasitic species – Viscum album) and the degree of polarity of the extracting agents. For the extracts with expressed anti- and proconvulsant features the chemical composition has been investigated.Conclusion. The detailed analysis of relationship between phytochemical composition and influence of the extracts on the experimental seizures has found that anticonvulsant peculiarities of extracts most probably depend on rutin high content, but for the herbal medicines with proved proconvulsant properties the role of individual biologically active compounds has not been defined
Resilienz als Gelingensfaktor

Zusammenfassung: Lebenskompetenzen und seelische Widerstandskraft (Resilienz) werden bei der Förderung kindlicher Entwicklung immer stärker berücksichtigt. Im vorliegenden Beitrag wird das Konzept der Resilienz vorgestellt und die Bedeutung von Schutz- und Resilienzfaktoren hervorgehoben. Es hat sich gezeigt, dass eine wertschätzende Beziehung sowie die gezielte Stärkung von Selbstwirksamkeit, Problemlösefähigkeiten und Bewältigungsstrategien Menschen im Umgang mit schwierigen Lebenssituationen unterstützen können.