Miracle-dz/UniFAR-FTUs huggingface dataset:
In Vivo Study on the Relationship between ALDH2 Gene Polymorphism and Efficacy of Nitroglycerin in Patients with Stable Angina

Objective To investigate the relationship between aldehyde dehydrogenase-2 (ALDH2) gene polymorphisms and the efficacy of nitroglycerin (GTN) in the CHD patients with stable angina pectoris.Method One hundred and thirteen CHD patients with stable angina pectoris,who were confirmed by coronary angiography (one of the main coronary arteries narrows ≥50%) and only sublingual nitroglycerin during acute stable angina pectoris attack were involved in this study.The whole patients were divided into two groups according to the efficacy of only sublingual nitroglycerin during acute stable angina pectoris attack:efficacious group (Group A) and inefficacious group (Group B). Among Group A,according to the time which was cost by relief of angina pectoris after sublingual nitroglycerin,we divided the patients into Group A1 (≤5 min,n=69) and Group A2 (5 min,n=18). We obtained the DNA from 2ml peripheral blood of each patient.Polymorphism chain reaction (PCR) and reverse direct sequencing were performed to screen the polymorphism of ALDH2 gene in exon 12.Result There is a Glu to Lys polymorphism of ALDH2 gene in exon 12 at position 504 (Gly504Lys). The frequencies of G and A allele in the total population was 0.819 and 0.181,respectively.No significant difference was found in the genotype distribution of ALDH2 gene between Group A and Group B (G/G:74.713% vs.61.538%,P0.05;A/A:6.897% vs.11.538%,P0.05). Among Group A,we did not find the significant difference in the distribution of ALDH2 gene between Group A1 and Group A2 (G/G:73.913% vs.77.778%,P0.05;A/A:4.348% vs.16.667%,P0.05),either.And ALDH2 genotype also did not show any significant difference between Group A1 and Group B (G/G:73.913% vs.61.538%;P0.05;A/A:4.348% vs.11.538%,P0.05). ConclusionThe genotype of G/A polymorphism in ALDH2 gene is not associated with the efficacy of nitroglycerin (GTN) in the CHD patients with stable angina pectoris.
Usable characteristics of a disc biomass grinding

It was investigated multi-disc grinding in directions knowledge of, describe and utilize, for design and structural purposes, the characteristics that indicate the relations between speeds idle movement, loads and the indicators of usable variables in the grinding space. The mathematical description of the states of and changes in grains, their surface and volume during movement (idle and working movement) of the components and assemblies in the multi-hole grinding process was obtained as a objective of this work.
Patient-Rated Outcomes of Lumbar Fusion in Patients With Degenerative Disease of the Lumbar Spine: Does Age Matter?

Study Design. Single-center retrospective study of prospectively collected data, nested within the Eurospine Spine Tango data acquisition system. Objective. The aim of this study was to assess the patient-rated outcome and complication rates associated with lumbar fusion procedures in three different age groups. Summary of Background Data. There is a general reluctance to consider spinal fusion procedures in elderly patients due to the increased likelihood of complications. Methods. Before and at 3, 12, and 24 months after surgery, patients completed the multidimensional Core Outcome Measures Index. At the 3-, 12-, and 24-month follow-ups, they also rated the Global Treatment Outcome and their satisfaction with care. Patients were divided into three age groups: younger (≥50 years <65 years; n = 317), older (≥65 years <80 years; n = 350), and geriatric (≥80 years; n = 40). Results. A total of 707 consecutive patients were included. The preoperative comorbidity status differed significantly (P < 0.0001) between the age groups, with the highest scores in the geriatric group. Medical complications during surgery were lower in the younger age group (7%) than in the older (13.4%; P = 0.006) and geriatric groups (17.5%; P = 0.007); surgical complications tended to be higher in the elderly group (younger, 6.3%; older, 6.0%; geriatric, 15.0%; P = 0.09). There were no significant group differences (P > 0.05) for the scores on any of the Core Outcome Measures Index domains, Global Treatment Outcome, or patient-rated satisfaction at either 3-, 12-, and 24-months of follow-up. Conclusion. Despite greater comorbidity and complication rates in geriatric patients, the patient-rated outcome was as good in the elderly as it was in younger age groups up to 2 years after surgery. These data indicate that geriatric age needs careful consideration of associated risks but is not per se a contraindication for fusion for lumbar degenerative disease. Level of Evidence: 4
The Role of Drug-coated Balloons in Infrapopliteal Intervention

The goal of infrapopliteal endovascular therapy is the re-establishment of straight-line flow to the foot with adequate perfusion of tissue. This treatment should be the first method in properly selected patients to relieve ischaemic rest pain, heal ulcers and prevent limb loss, improving quality of life. Percutaneous angioplasty (PTA) continues to be the cornerstone of infrapopliteal therapy. Metal stents are reserved for suboptimal PTA. Although data are accumulating that may eventually guide the use of alternative devices such as lasers, excisional and rotational atherectomy, drug-eluting stents or drug-coated balloons, we currently lack adequate evidence demonstrating improved outcomes. Endovascular therapy has expanded to include patients with severe co-morbidities such as renal failure and complex occlusive disease. Despite advances in below-the-knee (BTK) angioplasty balloons and a focus on angioplasty technique, current PTA results demonstrate one-year restenosis rates up to 80 %, depending on lesion complexity. Drug-coated balloons have demonstrated superior patency in the superficial femoral artery and it is yet to be determined if this technology can achieve improved patency and the clinical outcomes in the infrapopliteal region.
On the relationship between intensity changes and rainfall distribution in tropical cyclones over the North Indian Ocean

Using Tropical Rainfall Measuring Mission rain estimates the relationship between rainfall and intensity changes in tropical cyclones (TCs) over the North Indian Ocean (NIO) based on 71 TCs during 1997–2017 is investigated. The axisymmetric analyses revealed that climatologically the Bay of Bengal (BoB) TCs produce extremely heavy rainfall (~9–10 mm⋅hr−1) and Arabian Sea TCs produce very heavy rainfall (~7–8 mm⋅hr−1) in the storm inner core region (0–100 km). The inner‐core region receives three times higher rainfall than the outer region (100–300 km). The left‐forward sector experiences the maximum rainfall for any TC intensity over the NIO basin. A significant increase (decrease) in the rain rate is seen during normal to rapid intensification (weakening) phase. A notable decrease in rainfall of ~4.3 mm⋅hr−1 is observed for the rapidly weakening TCs. Slow‐moving TCs are generally stronger and produce heavy rainfall (2–4 mm⋅hr−1) up to ~300 km storm radius. As the translation speed increases, rainfall gradually shifts from rear to the forward sector of the TC. The asymmetry (wavenumber‐1) in TC rainfall structures revealed that rainfall maximum is located in the left‐forward sector for almost all intensity stages. The amplitude of wave number‐1 asymmetry in TC rainfall shows cyclonic shift as the TC intensity increases and is particularly prevalent in the BoB region. These analyses would be helpful as a baseline for evaluating the performance of numerical models and to identify the vulnerable areas for TC heavy rainfall.
Insolation and Glacial Meltwater Influence on Sea‐Ice and Circulation Variability in the Northeastern Labrador Sea During the Last Glacial Period

The variable amounts of ice rafted debris (IRD) and foraminifers in North Atlantic sediments are related to the abrupt, millennial‐scale alteration from Greenland stadials to interstadials during the last glacial period and indicate past ice sheet instabilities, changes in sea‐ice cover and productivity. In the Norwegian Sea, Greenland stadials were likely characterized by an extensive, near‐perennial sea‐ice cover whereas Greenland interstadials were seasonally ice‐free. The variability in other areas, such as the Labrador Sea, remains, however, obscure. We therefore investigated deep‐sea sediment core GS16‐204‐22CC retrieved south of Greenland. Using a multiproxy approach, we distinguish two sediment regimes and hence different environmental conditions between ca. 65 and 25 ka b2k. Regime 1 (~65‐49 ka b2k) is characterized by the dominance of planktic foraminifers in the sediments. During late MIS4 and early MIS3, the site was covered by near‐perennial sea‐ice with occasional periods of iceberg discharge. During the younger part of regime 1 the northeastern Labrador Sea was seasonally ice‐free with hardly any icebergs melting near the site and long‐term environmental conditions were less variable. Regime 2 (~49‐25 ka b2k) is characterized by pronounced stadial‐interstadial variability of foraminifer and IRD fluxes, suggesting an extensive sea‐ice cover during most Greenland stadials and seasonally ice‐free conditions during most Greenland interstadials. During MIS2 environmental conditions were very similar to those of the younger part of regime 1. While all Heinrich (H) related Greenland stadials are marked by depleted oxygen isotope values at our core site, only H4 and H3 are associated with pronounced IRD peaks.
Microscale Canopy Interactions in Aquatic Phototrophs

The light field on coral reefs varies in intensity and spectral composition, and is the key regulating factor for phototrophic reef organisms such as scleractinian corals harboring microalgal symbionts. However, the actual efficiency of light utilization in corals and the mechanisms affecting the radiative energy budget of corals are underexplored. We present the first balanced light energy budget for a symbiont-bearing coral based on a fine-scale study of the microenvironmental photobiology of the massive coral Montastrea curta. The majority (>96%) of the absorbed light energy was dissipated as heat, whereas the proportion of the absorbed light energy used in photosynthesis was ~4.0% under an irradiance of 640 μmol photons m-2 s-1. With increasing irradiance, the proportion of heat dissipation increased at the expense of photosynthesis. Despite such low energy efficiency, we found a high photosynthetic efficiency of the microalgal symbionts showing high gross photosynthesis rates and quantum efficiencies of ~0.1 O2 photon-1 approaching theoretical limits under moderate irradiance levels. Corals thus appear as highly efficient light collectors with optical properties enabling light distribution over the corallite/tissue microstructural canopy that enables a high photosynthetic quantum efficiency of their photosynthetic microalgae in hospite.
Total hip arthroplasty: implant breakage as a mechanism of failure

There are many failure mechanisms for total hip arthroplasty. The most common ones include fixation loosening, infection, and instability. Failure from implant breakage is rare and has only been reported in a few publications. It is increasingly rare with current biomaterials, designs and surgical techniques. Implant breakage and other mechanical failures have been reported with some of the contemporary implant designs over the past 2 decades. This review focuses on this particular failure mechanism for total hip arthroplasty.
Organic Carbon Flux in Ditches during the Growing Season in a Drained Alpine Peatland

The carbon budget dynamics of peatlands plays a crucial role in both the response of peatland ecosystems to environmental change and the effect of environmental change on peatlands. Studies on northern peatlands have suggested that the reliable assessment of the carbon budget must include the carbon flux at the land‐stream interface. But this argument has not been proved in the Qinghai‐Tibet Plateau, the world's largest alpine system. To address the knowledge gap, in the growing season (May to October) of 2016, we chose Riganqiao peatland, a typical peatland in the Zoige Basin of the Qinghai‐Tibet Plateau which has been intensely drained via ditches since the 1960s. The objective of this study was to measure the organic carbon export from ditches, and to estimate what proportion of the carbon budget can be attributed to this export. Results showed that, during the growing season in 2016, total organic carbon flux in ditches was 2,345 t (8.6 g m−2), of which particulate organic carbon accounted for 12% and dissolved organic carbon for 88%. This flux decreased the carbon budget of Riganqiao peatland by 11.2% (from +76.8 g m−2 to +68.2 g m−2), making it a weakened carbon sink. This result revealed that organic carbon export from ditches plays an important role in the carbon balance in peatland of the Qinghai‐Tibet Plateau.
A novel G26A variation in 5′ half of TGIF1 gene associates with high myopia in ethnic Kashmiri population from India

This study aims to look at novel variations in TGIF1 gene and explores their potential association with high myopia in an ethnic population from Kashmir (India). Genomic DNA was genotyped for polymorphic variations, and allele frequencies were tested for the Hardy–Weinberg disequilibrium in 240 ethnic Kashmiri cases with high myopia with a spherical equivalent of >−6 diopters (D) and compared with emmetropic controls with spherical equivalent within −0.5D in one or both eyes represented by a sample size of 228. In this study, we found a novel sequence variation G26A (GAT to AAT) in 5′ half of TGIF1 gene (p. aspartic acid >asparagine) at a frequency of 62% (148/240, P ≤ 0.0001). Variation appears to associate with high myopia significantly (P ≤ 0.001) as it happens to be present only in high myopia affected individuals. Further, it shows statistical significance for its association with gender and the degree of myopia (P ≤ 0.05). In addition, in silico predictions show that variation likely has an impact on the structure and functional properties of the protein. The assessment of the I-TASSER protein structure showed higher energy for a wild-type protein (−5820.186 kJ/mol) as compared to mutant protein (−6595.593 kJ/mol).
Spatio-Temporal Dynamics and Evolution of Land Use Land Cover Using Remote Sensing and GIS in Sebou Estuary, Morocco

Land use and land cover (LULC) represent the ongoing challenge of environmental variation. The understanding of the level and process of its change is the basis for any environmental planning and management. In Morocco, as everywhere in the world, human population densities are constantly increasing on the coastal zones. This results in a continuous and rapid acceleration of the use of coastal space and an increase in pressures on ecosystems and the different species they contain. The purpose of this study is the analysis of the changes in LULC from 1985 to 2017 in the coastal area of Sebou estuary, situated in the Northwest of the Moroccan Atlantic coast. The changes were identified and assessed after classifying a series of Landsat images taken during 1985, 2002 and 2017. The algorithm used for the classification is the Support Vector Machine (SVM), which yielded results with accuracy higher than 85%. The results of the land use land cover change describe phenomenal urbanization and deforestation, as well as an evolution of the agricultural sector, indicating the impact of anthropization in this vulnerable environment.
Analysis of Industrial Structure of Gansu Province Based on IO-SDA Method

Based on the IO-SDA economic growth factor model, the Gansu Provincial Input-output Table from 2002 to 2012 was used to analyze the industrial structure related issues. Studies have shown that traditional industries such as extractive industries, petroleum and petrochemical industries, and textile industries are still the leading industries for economic development in Gansu Province; the dependence of the primary and secondary industries on the tertiary industry is rising, but the development is relatively slow. The modern service industry has a limited role in promoting economic development; consumer demand and fixed capital formation are the primary factors driving the industrial development of Gansu Province. Therefore, it is necessary to optimize the industrial structure, develop leading industries and characteristic industries, and develop modern industrial clusters with outstanding advantages to realize the adjustment and optimization of the industrial structure of Gansu Province. Keywords—IO-SDA model; industrial structure; dynamic mechanism; Gansu Province
Protection of ecological corridors in spatial planning documents in Poland implementation problems

The paper discusses main theoretical and methodological assumptions regarding designation of ecological corridors and determination of their boundaries. It presents a review of concepts of ecological corridors prepared in Poland and draws attention to the lack of legal instruments which would ensure ecological network continuity. The paper discusses the state and scope of works on the implementation of the concept of the Lublin Ecological Network in updated spatial development plan of the Lublin Voivodship.
Cytochrome P4502E1 and Other Xenobiotics Metabolizing Isoforms in Pathogenesis of Male Reproductive Disorders

Cytochrome P4502E1 and Other Xenobiotics Metabolizing Isoforms in Pathogenesis of Male Reproductive Disorders Last decades investigations demonstrated significant decreasing of men fertility and sperm quality. Approximately, 50% clinically confirmed infertility cases are attributed to the male partners. Male infertility pathogenesis is investigated insufficiently; its direct interrelation with such pathologies as varicocele or urogenital infections was demonstrated only in 23% of cases. At present, it is supposed that different etiologic factors (including idiopathic) could start similar processes, which final result would be spermatozoids quality, and/or quantity decreasing. The present review discusses possible impact of cytochrome P-450 xenobiotics modulation effects directly in male reproductive organs, suggesting it as one of the mechanisms of subfertility development.
Expression quantitative de la couleur, liée à la réflectance diffuse, de quelques roches et minéraux

On a determine, de 400 a 800 nm, les spectres de reflectance diffuse des mineraux : goethite, hematite, ilmenite, olivine, hypersthene, labrador, grenat, hornblende, augite ; et des roches : andesite, verre basaltique, obsidienne, basalte, rhyolite, ignimbrite, eclogite, peridotite, anorthosite. Ces spectres permettent, en outre, de fournir une expression quantitative de la couleur de chaque echantillon, selon le systeme de coordonnees chromatiques dont on rappelle le principe. On montre l'interet de la reflectance diffuse et des valeurs de couleur pour le classement et l'identification a distance des materiaux de l'ecorce terrestre ou du systeme solaire.
Vertical distribution of planktonic foraminifera in the Subtropical South Atlantic: depth hierarchy of controlling factors

Abstract. Temperature appears to be the best predictor of species composition of planktonic foraminifera communities, making it possible to use their fossil assemblages to reconstruct sea surface temperature (SST) variation in the past. However, the role of other environmental factors potentially modulating the spatial and vertical distribution of planktonic foraminifera species is poorly understood. This is especially relevant for environmental factors affecting the subsurface habitat. If such factors play a role, changes in the abundance of deeper dwelling species may not solely reflect SST variation. In order to constrain the effect of subsurface parameters on species composition, we here characterize the vertical distribution of living planktonic foraminifera community across the subtropical South Atlantic Ocean, where SST variability is small but the subsurface water mass structure changes dramatically. Four planktonic foraminifera communities could be identified across the top 700 m of the E–W transect. Gyre and Agulhas Leakage faunas were predominantly composed of Globigerinoides ruber, Globigerinoides tenellus, Trilobatus sacculifer, Globoturborotalita rubescens, Globigerinella calida, Tenuitella iota and Globigerinita glutinata, and only differed in terms of relative abundances (community composition). Upwelling fauna was dominated by Neogloboquadrina pachyderma, Neogloboquadrina incompta, Globorotalia crassaformis and Globorotalia inflata. Thermocline fauna was dominated by Tenuitella fleisheri, Globorotalia truncatulinoides and Globorotalia scitula in the western side, and by G. scitula in the eastern side of the basin. The largest part of the standing stock was consistently found in the surface layer, but SST was not the main predictor of species composition, neither for the total fauna at each station nor in analyses considering each depth layer separately. Instead, we identified a consistent vertical pattern in parameters controlling species composition at different depths, in which the parameters appear to reflect different aspects of the pelagic habitat. Whereas productivity appears to dominate in the mixed layer (0–60 m), physical-chemical parameters are important at depth immediately below (60–100 m), followed by parameters related to the degradation of organic matter (100–300 m), and parameters describing the dissolved oxygen availability (> 300 m). These results indicate that the seemingly straightforward relationship between assemblage composition and SST in sedimentary assemblages reflects vertically and seasonally integrated processes that are only indirectly linked to SST. This also implies that fossil assemblages of planktonic foraminifera should also contain a signature of subsurface processes, which could be used for paleoceanographic reconstructions.
O segredo ineficiente revisto: o que propõem e o que aprovam os deputados brasileiros

Shugart and Carey posit that presidential democracies in which legislators have a parochial focus of representation are electorally inefficient because voters are not offered highly identifiable choices on national policies. Such systems are driven by an inefficient secret, which is essentially a nonpartisan representation of the policy process. To check the propositions of the inefficient secret model (ISM), this article investigates the aggregation level, effect, and subject of Brazilian deputies' legislative input and output. Our empirical analysis indicates that, although some ISM-related factors drive legislative output, there is partisanship in deputies' legislative input. This result means that the ISM underestimates the prospects for programmatic parties (especially in the opposition) to emerge within systems where the electoral and constitutional rules encourage particularism.