Miracle-dz/UniFAR-FTUs huggingface dataset:
Implications physiopathologiques de la Nestine lors du remodelage pulmonaire et cardiaque à la suite de l’infarctus du myocarde, du diabète et de l’hypertension pulmonaire

V TABLE DES MATIÈRES . VII LISTE DES TABLEAUX . XV LISTE DES FIGURES . XVII LISTE DES SIGLES ET DES ABRÉVIATIONS. XXII REMERCIEMENTS . XXXI CHAPITRE 1 : INTRODUCTION . 1 1.1 LE CŒUR . 2 1.1.1 De l’anatomie à la physiologie cardiaque . 2 1.1.1.1 Les tuniques de la paroi du cœur et le péricarde . 2 1.1.1.2 Les cavités du cœur . 3 1.1.1.3 Le système de conduction cardiaque . 4 1.1.2 Les types cellulaires cardiaques . 6 1.1.2.1 Les cardiomyocytes . 6 1.1.2.1.1 Les cellules cardionectrices . 11 1.1.2.1.2 La régénération des cardiomyocytes . 11 1.1.2.2 Les fibroblastes cardiaques . 14 1.1.2.2.1 La caractérisation morphologique et phénotypique des fibroblastes cardiaques . 15 1.1.2.2.2 L’origine des fibroblastes cardiaques . 18 1.1.2.2. 3 Les fonctions des fibroblastes cardiaques . 20 1.1.3 L’infarctus du myocarde . 22 1.1.3.1 L’épidémiologie et les facteurs de risques des maladies cardiovasculaires et de l’infarctus du myocarde . 22 1.1.3.2 La principale cause de l’infarctus du myocarde : l’athérosclérose . 25
Somatostatin and/or somatostatin-like immunoreactive endocrine-paracrine cells in the human prostate gland.

: We demonstrated the presence of somatostatin and/or somatostatin-like immunoreactive (SSLI) endocrine-paracrine (EP) cells for the first time in the human prostate gland. Specimens from 26 prostates removed at radical cystectomies were studied using the unlabeled-antibody peroxidase-antiperoxidase technique. The SSLI cells were located predominantly in the prostatic ducts in widely scattered clusters and were mostly of the closed type. Some SSLI cells had processes that were prominent, suggesting a paracrine role. The SSLI cells were always associated with aggregates of numerous argyrophil cells. The finding of SSLI cells in the prostate gland (particularly in association with other EP cells) is circumstantial evidence that other polypeptide hormones are present. The SSLI and other prostatic EP cells may play major roles in the pathophysiology of the prostate gland and have an effect on such diverse conditions as infertility, nodular prostatic hyperplasia, and prostatic carcinoma.
Role of MR Spectroscopy by Using Endo-rectal Coil in the Differential Diagnosis of Prostatic Carcinoma

Objective:To discuss the diagnostic value of the metabolic characteristics of normal prostate,prostatic carcinoma (PCA),benign prostatic hypertrophy (BPH) and peripheral zone benign node by using magnetic resonance spectroscopy (MRS). Methods:The MRS finding of 35 cases of PCA,34 cases of BPH including 7 cases of peripheral zone benign node proved by pathology were analyzed.The region of interest (ROI) was set on the middle slice of prostate or the region through the biggest lesion.The (choline+creatine)/citrate (CC/C) value of each region was measured quantitatively.Results:The average CC/C ratios of the normal prostate peripheral zone,the area of PCA,the region of prostate peripheral zone benign node and the central zone of BPH were separately 0.94±0.53,2.23±1.67,1.19±0.64 and 0.93±0.49. The average ratio of CC/C for prostate cancer was statistically higher than that of the region of prostate peripheral zone benign node and the central zone of BPH (t=2.78,P=0.01;t= 4.4,P=0.001). The ratio of CC/C in PCA was the biggest among all groups and there were 18 cases whose ratios of CC/C were bigger than 1.5 (51.4%). The other was about 1.0. Conclusion:The ratio of CC/C in PCA increases significantly.MRS may be useful in the differential diagnosis of PCA.
Gestational Diabetes Mellitus

OBJECTIVE To determine the impact of the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria on 1) gestational diabetes mellitus (GDM) diagnosis compared with the American Diabetes Association (ADA) criteria and 2) the fasting plasma glucose (FPG) to predict GDM. RESEARCH DESIGN AND METHODS In 10,283 pregnant women undergoing a 75-g oral glucose tolerance test (OGTT) for universal screening of GDM, two FPG thresholds (of the OGTT) were used to rule in and to rule out GDM. RESULTS The IADPSG and ADA criteria identified GDM in 3,875 (37.7%) women and 1,328 (12.9%) women, respectively (P < 0.0005). FPG thresholds of ≥5.1 mmol/l ruled in GDM in 2,975 (28.9%) women with 100% specificity, while <4.4 mmol/l ruled out GDM in 2,228 (21.7%) women with 95.4% sensitivity. FPG independently could have avoided the OGTT in 5,203 (50.6%) women. CONCLUSIONS The IADPSG criteria increased GDM prevalence nearly threefold. By circumventing a significant number of OGTTs, an initial FPG can greatly simplify the IADPSG diagnostic algorithm.
Electric energy consumption and economic growth in Togo

The general purpose of this study is to analyze the effect of the consumption of electric energy on Togo’s economic growth and check the direction of the causality between this consumption and economic growth. From a simple methodological approach, the study uses cointegration and causality techniques to meet its objectives and tests the research hypothesis that consumption of electric energy causes, as Granger puts, the economic growth. The results show that there is a positive correlation between economic growth, capital stock and consumption of electric energy with a negative effect energy crisis in 1983. These results also show that there is no causality between economic growth and consumption of electric energy, in other words, the consumption of electric energy dwells a small component of economic growth.
Regorafenib for treatment of imatinib- and sunitinib-resistant metastatic gastrointestinal stromal tumors

ABSTRACT Introduction: The treatment of gastrointestinal stromal tumors (GISTs) has been transformed by the use of small molecule KIT/PDGFRA tyrosine kinase inhibitors (TKIs). Unfortunately, most GIST tumors develop resistance to front-line (imatinib) and second-line (sunitinib) therapy. Regorafenib, a multi-targeted KIT/PDGFRA/VEGFR oral TKI, has been shown to improve progression-free survival in the third- or fourth-line setting. Areas covered: This review encompasses the pre-clinical and clinical studies of regorafenib for treatment of GIST. The reviewed studies were all those retrievable using the PubMed database as of December 2015. Expert opinion: Based on the results of a randomized, double-blind, placebo-controlled, phase III study, regorafenib is now firmly established as the only proven third-line therapy. Regorafenib’s activity in this setting is believed to be due to its activity against oncogenic forms of KIT/PDGFRA. Side effects are common with this agent; however, they can be effectively managed with a combination of supportive care, dose interruptions and dose reductions. In frail patients, starting at a lower dose with subsequent dose escalation/de-escalation may improve tolerance and optimize treatment. Regorafenib’s toxicity profile is similar to other oral TKIs with anti-VEGFR activity. Regorafenib is primarily metabolized by CYP3A4, and concomitant use of strong inducers/inhibitors of this enzyme should be avoided.
Community Pharmacists' Intervention: How a 6-episode of one-on-one intervention changed patients' attitudes towards their medication and disease self-management

Adherence to medication is reported to be <33%. Most people who suffer chronic conditions require pharmacological intervention; they collect prescription repeats every month creating an opportunity for further regular intervention by the community pharmacist. to investigate if pharmacist intervention in Chronic Disease Management in rural Australia could improve patients’ outcomes through better monitoring of disease markers, selfmanagement skills and medication adherence. This project was a pilot before and after, pragmatic study, which was designed as a foundation to support future definitive studies. The data was analysed in ASReml-R™ using linear mixed models or generalised linear mixed models. Using modified Health Education Impact Questionnaires™, there was 29.65% improvement in patients’ total score from pre and post clinical intervention. Patient education and ongoing interaction between patients and pharmacists enforced the importance of monitoring improving patients’ knowledge and self-management commitment. The use of prescription repeat collections as an opportunity to reinforce disease management messages deserves further investigation.
Accounting Fundamentals and Systematic Risk: Corporate Failure over the Business Cycle

In this paper, we use accounting fundamentals to measure systematic risk of distress. Our main testable prediction—that this risk increases with the probability of recessionary failure, P(R|F)—is based on a stylized model that guides our empirical analyses. We first apply the lasso method to select accounting fundamentals that can be combined into P(R|F) estimates. We then use the obtained estimates in asset-pricing tests. This approach successfully extracts systematic risk information from accounting data—we document a significant positive premium associated with P(R|F) estimates. The premium covaries with the news about the business cycle and aggregate failure rates. Additional tests underscore the importance of the “structure” imposed through recessionary-failure-probability estimation. The “agnostic” return predictor that relies only on past correlations between the same fundamental variables and returns exhibits markedly different properties. JEL Classifications: G12; G32; G33; M41.
A longitudinal study of lead mobilization during pregnancy : Concentrations in maternal and umbilical cord blood

The effect of pregnancy on blood lead concentrations is still a controversial question. The purpose of this study was to assess the maternal lead mobilization from bone during pregnancy and to evaluate the passage of this metal from the mother to the fetus. In 1993 - 1994, a longitudinal survey of the blood lead levels from 120 women, measured before and through pregnancy as well as at delivery was conducted in Reus (Catalonia, Spain). Serum iron and calcium levels were also analyzed. Blood samples were also obtained from umbilical cord after the cord had been severed, and lead concentrations were determined. Hematocrit-corrected maternal blood lead levels ranged from 0.06 μmol/l to 0.74 μmol/l. The geometric mean concentration of maternal blood lead before pregnancy and at parturition was 0.22 μmol/l. The average serum calcium and iron concentrations throughout the study were 2.40 mmol/l and 21. 6μmol/l, respectively. The geometric mean concentration of lead in umbilical cord blood was 0.19 μmol/l. A significant correlation between maternal blood lead levels at delivery and blood lead concentrations in the umbilical cord could be established (r = 0.6809, p < 0.001). Because the placenta is not a complete and effective barrier for lead, a supplement of dietary calcium is strongly suggested to prevent lead absorption during pregnancy. In addition, this supplement could also avoid a high mobilization of lead from bone. On the other hand, according to the results of this study together with data from previous investigations, in order to avoid misleading results and conclusions only longitudinal studies are designed to provide adequate information on blood lead levels during pregnancy. In these surveys blood lead concentrations should be corrected for hematocrit.
More attention should be paid to the basic research on corneal diseases

Comeal disease is the second leading cause of blindness in China. Improvement of the diagnosis and treatment of corneal disease depends on the deepening and widening of the basic research in this area. In some fields, the research conducted in our country has reached the top level in the world. However, in general, obvious disparities exist between China and the developed countries in terms of lack of systematic research, limited financial support, the insufficiency of the quality and quantity of researchers and so on. Based upon the current situations of China, the future basic research on comeal diseases should focus on the mechanism of infectious corneal diseases, gene mutation of comeal dystrophy, corneal tissue engineering, the pathogenesis of dry eye, the reconstruction after severe chemical bums of ocular surface, the pathogenesis of ocular surface neovascularization, the prophylaxis and therapy of comeal graft rejection, etc. Other important measures to improve the basic research of comeal diseases in our country would include applying for more research funds, training high quality researchers, and strengthening the cooperation with different disciplines and with other countries.
A brief history of the international monetary system since Bretton Woods

This paper provides a historical background to contemporary debates on the international monetary system: their genesis, similarities, and differences of problems it has faced at different times. It looks sequentially at the design of the Bretton Woods system; the tensions it faced since the 1960s and its collapse in the early 1970s; the management of the collapse, the failure to agree on a new system, and the resulting non-system that followed; the maturing of these ad hoc arrangements, and the reforms after the North Atlantic financial crisis and debates on how to build up a broader global 'financial safety net'.
Survey on work satisfaction and stability of community health workers in Fuzhou City

We surveyed on the satisfaction and stability of community health workers in Fuzhou using questionnaire and interview.The results showed that the satisfaction of community health worker was generally poor.They were mostly dissatisfied with their salaries and welfare.It was serious that doctors with good education background left their jobs.Therefore,we proposed to increase salary,meet the need of self-realization,and pay attention to your doctors' growing.
The association between smoking and clinical manifestations in patients with Behçet's disease

Background/Aims: There is controversy related to the role of smoking in affecting the clinical features of patients with Behcet’s disease (BD). The aim of this study was to investigate the effect of smoking on clinical manifestations in Korean BD patients. Methods: We enrolled 131 patients with BD who fulfilled the International Study Group (ISG) criteria of 1990. The disease-related clinical features of BD―oral ulcers, genital ulcers, ocular lesions, arthritis, vascular lesions, gastrointestinal lesions―and central nerve lesions, smoking history, disease duration, and the presence of HLA-B51 were retrospectively assessed through medical record reviews and patient interviews. Statistical analysis was performed using Chi-square, Fisher’s exact, or student t-test, if appropriate. Results: The frequencies of vascular and gastrointestinal lesions in smokers were significantly increased compared to those in non-smokers (p=0.040, OR=3.341, 95% CI 1.083-10.305; p=0.012, OR=3.878, 95% CI 1.379-10.906, respectively). Male smokers developed vascular lesions more frequently compared to female smokers, male non-smokers, and female non-smokers (p=0.025, OR=3.896, 95% CI 1.245-12.196). Moreover, smoking, male sex, and positive HLA-B51 may be risk factors for the development of gastrointestinal lesions in BD. Venous lesions were more frequently found in male smokers compared with other patients (p=0.038). Conclusions: Smoking may be associated with the development of vascular and gastrointestinal lesions in Korean BD patients. A large population prospective assessment of the clinical effect of smoking on BD is needed.
The Institutional Impact of the Georgia HOPE Scholarship

This paper examines the effects offinancial aid policies on the behavior of post-secondary institutions. Using the introduction of the Georgia HOPE Scholarship as a natural experiment, it investigates the impact of the policy on college pricing, institution aid, expenditures, and state appropriations. The results suggest that four-year colleges in Georgia, particularly private institutions, did respond by increasing student charges. In the most extreme case, colleges recouped approximately 30 percent of the scholarship award. As a result, the institutional responses reduced the intended benefit of the scholarship and increased the cost of college for nonrecipients.
Association of Smoking,Residential Environment and Polymorphisms with Lung Cancer

[Objective] To reveal risk factors of lung cancer. [Methods] A case-control study was designed with 781 lung cancer patients and 781 control subjects.Both epidemiological investigation and laboratory examination were performed in every subject. [Results] We revealed that smoke during cooking,irritant smell after decoration,insufficient ventilation,smoking and cooking presented increased risk of developing lung cancer.The low temperature of oil during cooking and rs144848 C allele were identified as protective factors.Smoking,smoke during cooking and living in bungalow showed a synergic effect. [Conclusion] The results suggest that smoking and air pollution are associated with lung caner.Rs144848 C allele may have protective effect on lung cancer.
Precarious Lives: Food, Work and Care After the Global Food Crisis

September 2016 Precarious Lives: Food, Work and Care After the Global Food Crisis Prarious Les: Fod, W rk nd C re After he G lbal Food C risis ScoVilliers, C hholm , W ajiku Klbert nd H osain This report is the result of four years of collaboration between Oxfam GB, the Institute of Development Studies and qualitative and quantitative researchers in ten countries. It builds on a prior IDS-Oxfam study into the effects of the global food crisis on the lives of people on low and uncertain incomes, which ran between 2009 and 2011 in four countries. The longitudinal study synthesised here was carried out between 2012 and 2015 and involved annual visits to communities in rural, urban and peri-urban sites, along with commissioned reviews of national-level prices and policies over the period. With the help of the research partners and of Oxfam offices around the world, the findings have already begun to be disseminated and discussed with communities, government representatives and members of civil society at multiple levels. The research was funded by the UK Department for International Development, Irish Aid and Oxfam.
An ethnobotanical study of medicinal plants used in the coastal bushland of Lindi District, Southeast Tanzania

Background: An ethnomedicinal study was conducted to document the medicinal plants used for treating diseases in the coastal bushland of the Lindi Region in southeastern Tanzania. Methods: Semistructured interviews were conducted between August 2016 and September 2018 to collect information regarding local medicinal plant names, the diseases that they were used to treat, and the plant organ used to prepare remedies. The data collected were compared with previous reports within Tanzania and elsewhere and counted and cross-tabulated when appropriate. Results: A total of 108 species belonging to 49 families and 91 genera were reported. The most commonly used plant families were Caesalpiniaceae and Euphorbiaceae. The most commonly used plant types in the coastal bushland were trees and shrubs, and leaves were mostly used due to various reasons. The majority of the recorded plants were indigenous/natural, which included one newly identified and five endemic species. Most of the local names originated from the Mwera ethnic group. A total of 268 usage variations based on a combination of the plant organ used and disease treated were recorded for the species identified, including edibility. The documented diseases treated with medicinal plants included hernia, convulsion, stomachache, snake bites, skin parasites, abscesses, tinea capitis, malaria, and measles. Medicinal plants related to magic also constituted a significant proportion of uses. In this study, 64.9% of the plant species used to manage diseases were previously reported medicinal species. Moreover, 29.1% were used to manage a similar disease and 13.1% for the same disease, whereas 9.3% of the medicinal plants had the same organ used to treat the same disease as reported. Of the plants identified, 28.7% were edible. Within the study, new treatments that have not been previously reported in Tanzania were identified for 35.1% of the species. Conclusions: The use of mostly native plants to manage diseases in the study area was validated through cross-checking uses at other locations, and the therapeutic claims of the interviewees were verified. Some of the new findings and new species utilized may provide a basis for new medicinal compounds and remedies in the future.
Dysfunctional Network and Mutation Genes of Hypertrophic Cardiomyopathy

Background Hypertrophic cardiomyopathy (HCM) is a group of heterogeneous diseases that affects the myocardium. It is also a common familial disease. The symptoms are not common and easy to find. Objective In this paper, we aim to explore and analyze the dysfunctional gene network related to hypertrophic cardiomyopathy, and the key target genes with diagnostic and therapeutic significance for HCM were screened. Methods The gene expression profiles of 37 samples (GSE130036) were downloaded from the GEO database. Differential analysis was used to identify the related dysregulated genes in patients with HCM. Enrichment analysis identified the biological function and signaling pathway of these differentially expressed genes. Then, PPI network was built and verified in the GSE36961 dataset. Finally, the gene of single-nucleotide variants (SNVs) in HCM samples was screened by means of maftools. Results In this study, 920 differentially expressed genes were obtained, and these genes were mainly related to metabolism-related signaling pathways. 187 interacting genes were identified by PPI network analysis, and the expression trends of C1QB, F13A1, CD163, FCN3, PLA2G2A, and CHRDL2 were verified by another dataset and quantitative real-time polymerase chain reaction. ROC curve analysis showed that they had certain clinical diagnostic ability, and they were the potential key dysfunctional genes of HCM. In addition, we found that PRMT5 mutation was the most frequent in HCM samples, which may affect the pathogenesis of HCM. Conclusion Therefore, the key genes and enrichment results identified by our analysis may provide a reference for the occurrence and development mechanism of HCM. In addition, mutations in PRMT5 may be a useful therapeutic and diagnostic target for HCM. Our results also provide an independent quantitative assessment of functional limitations in patients with unknown history.
Effects of vitamin D supplementation on depression in patients with colorectal cancer

Background: The relation and possible mechnism of vitamin D supplementation on depression in colorectal cancer (CRC) patients was not clearly ; Objective: This study investigates the effect of vitamin D supplementation on depression in colorectal cancer (CRC) patients. Methods : We recruited 168 CRC patients and 168 healthy control subjects into this study. 17-item Hamilton Depression Rating Scale (HDRS-17) was used to assess depression. Results: We found that 25-hydroxyvitamin D (25(OH)D) concentrations were independently associated with depression among CRC patients. For the 45 depressed patients receiving vitamin D3 supplementation, depression scores decreased markedly with 25(OH)D concentrations increasing to normal. Conclusion: Therefore, we advise monitoring this indicator in CRC patients and supplementing with vitamin D 3 when their 25(OH)D concentrations are low.