Miracle-dz/UniFAR-FTUs huggingface dataset:
Pharmacists and vaccination in pregnancy

Introduction Across Canada, pharmacists are increasingly involved in providing vaccinations. The accessibility of pharmacists provides opportunity to improve adult vaccination rates for influenza and other routinely recommended vaccines. Since pregnant women are an important segment of the population that may require vaccines, pharmacists should be aware of vaccine recommendations as well as contraindications in pregnancy. Physiologic changes that occur during pregnancy, such as alterations in the balance of type 1 and 2 T-helper cells, increase the susceptibility of pregnant women to illness. Vaccination in pregnancy provides protection not only for the woman but also for the fetus and infant in the first few vulnerable months of life (i.e., before infant vaccines can be given) and thus addresses a previous gap in vaccination coverage. However, misperceptions around the safety of vaccines have been shown to influence patient decisions to refuse vaccinations during pregnancy. Other commonly reported patient barriers include not receiving a provider recommendation for the vaccine and pregnant women perceiving they are not at risk for contracting the disease. This article highlights vaccines that are recommended in all pregnant women, as well as vaccines that should be avoided. The significant role and responsibility of pharmacists in proactively promoting maternal vaccination are also underscored (summarized in Box 1).
A Baker’s Dozen of Top Antimicrobial Stewardship Intervention Publications in 2018

Abstract With an increasing number of antimicrobial stewardship–related articles published each year, attempting to stay current is challenging. The Southeastern Research Group Endeavor (SERGE-45) identified antimicrobial stewardship–related peer-reviewed literature that detailed an actionable intervention for 2018. The top 13 publications were selected using a modified Delphi technique. These manuscripts were reviewed to highlight the actionable intervention used by antimicrobial stewardship programs to provide key stewardship literature for teaching and training as well as to identify potential intervention opportunities within one’s institution.
ASSESSING THE PROVISION OF QUALITY STUDENTS' SERVICE AND SATISFACTION IN TERTIARY INSTITUTION IN GHANA; Using Cape Coast Polytechnic as Case Study

Quality students’ service of higher education, however, has been largely overlooked when the issue of quality service has been considered. This is not surprising. Because normally higher education, primarily, remain focused on teaching and research, with the administration tasks existing as a supporting role. Again, most of research works on quality services have ignored the education sector. Ironically even academicians who will be the immediate beneficiaries even focuses their research works on other sectors of the economy. This is partly so, because academicians in tertiary institutions focus on that area that concerns them the most and where they can easily get fund to finance their work. This has meant, however, that the role of quality student service in tertiary organizational culture has been somehow ignored. But focus on teaching and research alone cannot be the only pre-requisites for success in academia. Quality student service is the focus of the moment in higher education sector everywhere in the world and Ghana cannot be exception, ensuring that institutions maintain a high level of attention to quality issues will not only attract more students but also increase their internally generated fund. The research assesses the provision of quality student service and satisfaction in tertiary institution in Ghana; using Cape Coast Polytechnic as a case study.
ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer’s Disease

Significant knowledge about the pathophysiology of Alzheimer’s disease (AD) has been gained in the last century; however, the understanding of its causes of onset remains limited. Late-onset AD is observed in about 95% of patients, and APOE4-encoding apolipoprotein E4 (ApoE4) is strongly associated with these cases. As an apolipoprotein, the function of ApoE in brain cholesterol transport has been extensively studied and widely appreciated. Development of new technologies such as human-induced pluripotent stem cells (hiPSCs) and CRISPR-Cas9 genome editing tools have enabled us to develop human brain model systems in vitro and readily manipulate genomic information. In the context of these advances, recent studies provide strong evidence that abnormal cholesterol metabolism by ApoE4 could be linked to AD-associated pathology. In this review, we discuss novel discoveries in brain cholesterol dysregulation by ApoE4. We further elaborate cell type-specific roles in cholesterol regulation of four major brain cell types, neurons, astrocytes, microglia, and oligodendrocytes, and how its dysregulation can be linked to AD pathology.
DOES ASPIRIN PRETREATMENT PREVENT DIABETES IN RATS

Aspirin is irreversibly acetylates cyclooxygenase, thus inactivating this enzyme and blocking prostaglandin synthesis,is rapidly deacetylated by esterases in the body, yielding salicylate, which has anti-inflammatory, antipyretic, and analgesic effects and anti thrombotic , antioxidant and anti diabetic effects. Diabetes was induced in neonatal rats by streptozotocin (STZ). Rat pups (neonates) were divided in to three groups consisting of six each. It was found that only by 8 weeks of animals and thereafter n5 STZ rats showed mild hyperglycemia. The first group served as control group, second group was treated only with streptozotocin (90mg/kg, i.p) and third group was treated with aspirin (1mg/kg/day, p.o) for one week (0-7days) before streptozotocin. On day 8, blood samples were collected and estimated fasting serum glucose levels (10 weeks), total anti oxidant status and lipid profiles for two weeks (8 and 10). Aspirin treated groups showed no increase in blood glucose levels following STZ treatment when studied for 10 weeks. Total antioxidant status was decreased in STZ treated group and increased in aspirin treated group similarly there was a significant influence on lipid profile following aspirin protection. The present study indicates that aspirin pretreatment seems to protect pancreas from damage caused by STZ and maintains good lipid profile in diabetic rats and increases insulin sensitivity. It also brings about improvement of antioxidant status in diabetes mellitus.
On Electrical Load Disaggregation using Recurrent Neural Networks

In a residential setting, Load disaggregation (LD) is about obtaining appliance-specific operational details in terms of time and power consumption by processing aggregate power consumption data. The disaggregated load information helps utilities to categorize customers based on their usage patterns, facilitating optimal demand response design. Further, LD helps customers to know about their energy-consuming behavior, which is beneficial in reducing the consumption. To be able to provide appliance-specific consumption patterns for aforementioned goals, apart from accurate load identification, estimates of energy consumption of appliances of interest are necessary. In short, it is essential to cull out operational waveform of each of the requisite appliance. Towards this end, very few results have been reported in the literature related to estimating the operational wave-forms, even for large power consuming appliances. In this work, we address this problem using a deep-learning architecture with Recurrent Neural Networks (RNN) variants like Long-Short Term Memory networks (LSTM) and Generalized Recurrent Unit networks (GRU). In addition, a simple but effective technique in pre-processing of the aggregated data is proposed and implemented to identify and reconstruct the consumption pattern of low-power consuming appliances like Refrigerator.
LncRNA SNHG1 contributes to tumorigenesis and mechanism by targeting miR-338-3p to regulate PLK4 in human neuroblastoma.

OBJECTIVE Neuroblastoma is a common malignancy in children. Despite the occurrence of diverse therapies in recent years, the survival rate of patients with high-risk NB is still unpredictable due to the high metastatic potential and poor prognosis. Therefore, it is urgent to study the molecular mechanism of NB metastasis. SNHG1 has been reported to be closely related to the development, metastasis, and prognosis of many cancers. The purpose of this study was to clarify the molecular mechanism of the role of SNHG1 in NB tumors. PATIENTS AND METHODS The expression levels of SNHG1, miR-338-3p, and PLK4 were detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) and Western blot, respectively. The functional targets between miR-338-3p and SNHG1 or PLK4 were predicted by online software Diana tools and observed by Luciferase reporter assay and RIP assay. Cell proliferation was measured by MTT assay. Cell migration and invasion were operated through flow cytometry. The expression of p-AKT was quantified by Western blot. Xenograft tumor model was established to confirm the biological role of SNHG1 in NB in vivo. RESULTS The expression levels of SNHG1 and PLK4 were increased in NB tissues and cells, and miR-338-3p expression was on the contrary. PLK4 was verified as a direct target of miR-338-3p and miR-338-3p could specially bind to SNHG1. The negative effect of SNHG1 down-regulation on cell proliferation, migration, and invasion could be rescued by miR-338-3p inhibition. The suppression of miR-338-3p mimics on cell proliferation, migration, and invasion could be reversed by PLK4 overexpression. In addition, SNHG1 knockdown weakened the volume and weight of tumor in vivo. CONCLUSIONS SNHG1 conduced to tumorigenesis and mechanism by upregulating PLK4 and by acting as miR-338-3p sponge in neuroblastoma.
Small Dense Low-Density Lipoprotein Cholesterol and the Risk of Coronary Heart Disease in a Japanese Community

Aims: This study aims to investigate the association between serum small dense low-density lipoprotein (sdLDL) cholesterol level and the development of coronary heart disease (CHD) in a Japanese community. Methods: A total of 3,080 participants without prior cardiovascular disease, aged 40 years or older, were followed up for 8 years. The participants were divided into the quartiles of serum sdLDL cholesterol levels. The risk estimates were computed using a Cox proportional hazards model. Results: During the follow-up period, 79 subjects developed CHD. Subjects in the highest quartile had a 5.41-fold (95% confidence interval, 2.12–13.82) higher risk of CHD than those in the lowest quartile after controlling for confounders. In the analysis classifying the participants into four groups according to the levels of serum sdLDL cholesterol and serum low-density lipoprotein (LDL) cholesterol levels, the risk of CHD almost doubled in subjects with sdLDL cholesterol of ≥ 32.9 mg/dL (median), regardless of serum LDL cholesterol levels, as compared with subjects with serum sdLDL cholesterol of < 32.9 mg/dL and serum LDL cholesterol of < 120.1 mg/dL (median). When serum sdLDL cholesterol levels were incorporated into a model with known cardiovascular risk factors, c-statistics was significantly increased (from 0.77 to 0.79; p = 0.02), and the net reclassification improvement was also significant (0.40; p < 0.001). Conclusions: The present findings suggest that the serum sdLDL cholesterol level is a relevant biomarker for the future development of CHD that offers benefit beyond the serum LDL cholesterol level and a possible therapeutic target to reduce the burden of CHD in a Japanese community.
Katydids (Orthoptera: Tettigoniidae) of Gorongosa National Park and Central Mozambique.

A list of 60 species of the Tettigoniidae (Orthoptera) recorded from Gorongosa National Park and provinces Sofala and Manica in central Mozambique is provided and their natural history is discussed. Of these, 58 species are illustrated and bioacoustic data are presented for 47 species. Two new genera and 9 new species are described: Gorongosa carri gen. et sp. n. , Ovonotus abreuae gen. et sp. n. , Afroagraecia muagurai sp. n. , Enyaliopsis iaculator sp. n. , Eurycorypha parkeri sp. n. , Eurycorypha stalmansi sp. n. , Eulioptera carolli sp. n. , Eulioptera mutembai sp. n. , and Parpyrrhicia guytonae sp. n. Four species of Ruspolia are recognized as potentially new and their bioacoustic data are presented. Pseudorhynchus pungens meridionalis Ragge, 1969 is synonymized with Pseudorhynchus pungens pungens (Schaum, 1853); Angustithorax spiniger Massa, 2015 is synonymized with Oxyecous magnus Ragge, 1956; and the synonymy of Lanista africana (Walker, 1870) with Lanista annulicornis (Walker, 1869) is reversed. Two species, G. carri and O. abreuae, appear to be endemic to Mt. Gorongosa and 24 species are recorded for the first time from Mozambique.
I CAN'T SLEEP IN MY BED: THE RELATIONSHIP BETWEEN SLEEP AND LATE-LIFE HOARDING

Abstract Hoarding disorder in late life has been associated with increased risk for medical conditions and decreased ability to perform activities of daily living in the home; however, no studies have yet examined the relationship between geriatric hoarding and sleep. This study represents a secondary data analysis of older adults who received 26 sessions of group behavioral treatment for hoarding disorder (n = 41; mean age 64, range 55-85). Baseline sleep disturbance was significantly associated with hoarding severity, even when controlling for inability to sleep in a bed due to household clutter level. However, no significant change in sleep disturbance was reported following completion of treatment and baseline sleep disturbance was not significantly predictive of change in hoarding symptom severity. Findings suggest that disturbed sleep quality is associated with greater hoarding symptom severity but does not preclude positive symptom change in treatment.
PERCEPCIÓN DE LA CULTURA DE LA SEGURIDAD DE LOS PACIENTES POR PERSONAL DE ENFERMERÍA NURSING PERCEPTION OF PATIENT SAFETY CULTURE

RESUMEN Objetivo: Identificar las areas de fortaleza y oportunidad de mejora continua, percibidas por el personal de en-fermeria en relacion a la cultura de seguridad en la atencion de los pacientes en un Hospital General del Sistema de Salud, en Tampico, Tamaulipas, Mexico. Material y metodo: estudio cuantitativo, descriptivo con diseno transversal, realizado en un hospital de segundo nivel de atencion. Muestra fue de 195 enfermeras, obtenida en un muestreo probabilistico por turnos. La recoleccion de los datos para el analisis de la cultura de la seguridad fue a traves de un indicador tipo encuesta de la Agency for Healthcare Research and Quality-AHQR, validada al contexto de espanol como Cuestionario sobre seguridad de los pacientes, version espanola del Hospital Survey on Patient Safety. Resultados: Las dimensiones percibidas como fortalezas son el trabajo en equipo en la unidad/servicio y aprendizaje organizacional. Las dimensiones percibidas hacia la mejora continua fueron: dotacion de personal, respuesta no punitiva a los errores, apoyo de la gerencia del hospital en la seguridad del paciente, percepcion de seguridad, problemas en cambios de turno y transiciones entre servicios/unidades y franqueza de la comunicacion. El clima de seguridad fue evaluado con una media de 7,35. El mayor porcentaje no reporta eventos adversos asociados a la atencion para la salud. Conclusion: el indicador utilizado permitio identificar la percepcion global del personal de enfermeria hacia la seguridad en la atencion del paciente, identificando seis dimensiones problematicas con oportunidad hacia la mejora continua; asi como dos dimensiones fuertes dentro de la cultura de seguridad.
The Contribution of Carotenoids, Phenolic Compounds, and Flavonoids to the Antioxidative Properties of Marine Microalgae Isolated from Mediterranean Morocco

This study aimed to investigate the potential of four sea water microalgae, isolated and cultivated at M′diq Bay in Morocco, as a new source of natural antioxidants. These microalgae belong to different classes, including Phaedactylium tricornitum (Bacillariophyceae), Nannochloropsis gaditana (Eustigmatophyceae), Nannochloris sp (Trebouxiophyceae), and Tetraselmis suecica (Chlorodendrophycea). The antioxidant properties were screened by the use of in vitro assays, namely 2,2-difenil-1-picrylhydrazyl, Ferric reducing antioxidant power, and Ferrous ions chelating activity, and compoundidentification was carried out in methanol and acetone extracts of both dried and fresh microalgae biomass by HPLC–PDA–MS analysis. Among the investigated microalgae, Phaedactylium tricornutum was the richest one regarding its carotenoid (especially all-E-fucoxanthin) and phenolic (especially protocatechuic acid) contents, as well as antioxidant activity (65.5%), followed by Nannochloris sp, Tetraselmis suicica, and Nannochloropsis gaditana, with antioxidant activity of 56.8%, 54.9%, and 51.1%, respectively.
Student veterans and adjustment to college: Making meaning of military experiences

Abstract Objective This study examined the relationships among meaning making, military stressor severity, and adjustment to college among student service members/veterans (SSM/Vs). Participants Participants were 128 SSM/Vs enrolled in postsecondary education from April to June 2016. Methods Participants completed online self-report rating scales of stressor severity for their most stressful military event, meaning made of that stressor, and adjustment to college. Results Regression analyses revealed that made meaning of military stressors was associated with more positive academic, social, and emotional adjustment to college. Stressor severity was not associated with adjustment, nor did made meaning moderate the relationship between stressor severity and adjustment to college. Conclusion These findings provide preliminary evidence that making meaning of stressful military experiences can promote academic, social, and emotional adjustment to college among SSM/Vs and has implications for incorporating meaning making strategies into university and clinical programs aimed at promoting adjustment to college in this population.
NREM sleep is the state of vigilance that best identifies the epileptogenic zone in the interictal electroencephalogram

Interictal epileptiform anomalies such as epileptiform discharges or high‐frequency oscillations show marked variations across the sleep‐wake cycle. This study investigates which state of vigilance is the best to localize the epileptogenic zone (EZ) in interictal intracranial electroencephalography (EEG).
Severe late dysphagia after multimodal treatment of stage III/IV laryngeal and hypopharyngeal cancer.

BACKGROUND Long-term side effects after radiotherapy for organ preservation 'could deteriorate' the laryngeal function. This study intended to identify the incidence of severe late dysphagia following the multimodal treatment for stage III/IV laryngeal and hypopharyngeal cancer 'to evaluate the function of larynx'. METHODS The medical records of patients successfully treated for laryngeal and hypopharyngeal cancer with a multimodal approach, including radiotherapy, were retrospectively analyzed. 'Functional larynx was defined as tolerable oral diet without severe late dysphagia or tracheostoma'. RESULTS The study included 99 patients with a median follow-up period of 72 months. 'Tracheostomy during the follow-up period was required in only one patient due to aspiration pneumonia, and dysphagia is the main determinant for functional larynx'. The probability of maintaining functional larynx was 63% for 10 years, when the treatment was started with radiotherapy or concurrent chemoradiotherapy. In upfront surgery (operation first and adjuvant radiotherapy/concurrent chemoradiotherapy) group, 37% of patients required total laryngectomy as primary treatment and 43% of patients could maintain laryngeal function for 10 years. And severe late dysphagia in the latter group developed mainly after laryngeal preservation surgery. The patients aged ≥65 years showed significantly higher incidence of dysphagia. Severe late dysphagia was very rare in laryngeal cancer successfully cured with radiotherapy/concurrent chemoradiotherapy (1/25, 4%); however, it gradually increased over time in hypopharyngeal cancer patients showing a statistically significant difference from laryngeal cancer patients (P = 0.040). CONCLUSION Severe late dysphagia occurred in 19.2% of patients treated for laryngeal and hypopharyngeal cancers, regardless of whether treatment started with radiotherapy/concurrent chemoradiotherapy or surgery.
Reliability and Criterion Validity of the Assess2Perform Bar Sensei

The Assess2Perform Bar Sensei is a device used to measure barbell velocity for velocity-based training that has not yet been validated. The purpose of this study was to determine criterion validity and reliability of the Assess2Perform Bar Sensei in barbell back squats by comparing it against the GymAware PowerTool, a previously validated instrument. Sixteen injury-free, resistance-trained subjects (eleven males and five females) were recruited. Subjects were tested for their back squat one repetition maximum (1RM). Then, on two separate days, subjects performed two sets of three repetitions at loads of 45%, 60% and 75% 1RM. The GymAware PowerTool and Bar Sensei were attached to the barbell in similar locations for concurrent collection of mean concentric velocity (MCV) and peak concentric velocity (PCV). The Bar Sensei and PowerTool showed generally fair to poor agreement for MCV and PCV when subjects lifted 45% of 1RM (intraclass correlation;ICC 0.4–0.59), and they showed poor agreement when subjects lifted 60% and 75% of 1RM (ICC 0.3–0.4). Inter-repetition/within-set reliability for the Bar Sensei ranged between ICC = 0.273–0.451 for MCV and PCV compared to the far more reliable PowerTool (ICC = 0.651–0.793). Currently, the Bar Sensei is not a reliable or valid tool for measuring barbell velocity in back squats.
In situ multiplex immunofluorescence analysis of the inflammatory burden in kidney allograft rejection: A new tool to characterize the alloimmune response

The exact composition of leukocyte infiltration during kidney allograft rejection is difficult to comprehend and visualize on the same biopsy slide. Using an innovative technology of multiplex immunofluorescence (mIF), we were able to detect simultaneously NK cells, macrophages, and T cells and to determine their intra‐ or extravascular localization using an endothelial marker. Twenty antibody‐mediated rejection (ABMR), 20 T cell–mediated rejection (TCMR), and five normal biopsies were labeled, with automatic leukocyte quantification and localization. This method was compared to a classic NKp46 immunohistochemistry (IHC) with manual quantification and to mRNA quantification. mIF automatic quantification was strongly correlated to IHC (r = .91, P < .001) and to mRNA expression levels (r > .46, P < .021). T cells and macrophages were the 2 predominant populations involved in rejection (48.0 ± 4.4% and 49.3 ± 4.4%, respectively, in ABMR; 51.8 ± 6.0% and 45.3 ± 5.8% in TCMR). NK cells constituted a rare population in both ABMR (2.7 ± 0.7%) and TCMR (2.9 ± 0.6%). The intravascular compartment was mainly composed of T cells, including during ABMR, in peritubular and glomerular capillaries. However, NK cell and macrophage densities were significantly higher during ABMR in glomerular and peritubular capillaries. To conclude, this study demonstrates the feasibility and utility of mIF imaging to study and better understand the kidney allograft rejection process.