Miracle-dz/UniFAR-FTUs huggingface dataset:
Inducible Nitric Oxide Synthase Modulates Cyclooxygenase-2 Activity in the Heart of Conscious Rabbits During the Late Phase of Ischemic Preconditioning

Cyclooxygenase-2 (COX-2) is known to mediate the cardioprotective effects of the late phase of ischemic preconditioning (PC); however, the signaling pathways involved in COX-2 induction following ischemic PC are unknown. In addition, although inducible nitric oxide synthase (iNOS) has been identified as a co-mediator of late PC together with COX-2, the interaction between iNOS and COX-2 in the heart is unknown. Using conscious rabbits, we found that the induction of COX-2 expression 24 hours after ischemic PC was blocked by pretreatment with inhibitors of protein kinase C (PKC), Src protein tyrosine kinases (PTKs), and nuclear factor-κB (NF-κB) but not by inhibitors of NOS or scavengers of reactive oxygen species (ROS). The selective iNOS inhibitors SMT and 1400W, given 24 hours after PC, abrogated the increase in myocardial prostaglandin E2 (PGE2) and 6-keto-PGF1α, whereas the selective soluble guanylate cyclase inhibitor ODQ had no effect. COX-2 selective inhibitors (celecoxib and NS-398) did not affect.
Alternation of the flickering morphology between the high and low state in MV Lyr

AIMS: We studied unique data of a nova-like system MV Lyr during transition from the high to low state and vice versa taken by the Kepler space telescope. We were interested in evolution of frequency components found previously by Scaringi et al. in different data also obtained by Kepler. METHODS: We divided the light curve into 10 day segments and investigated the corresponding power density spectra. We searched for individual frequency components by fitting with Lorentzian functions. Additionally, we investigated the variability using averaged shot profiles calculated from the light curve divided into 10 equally spaces subsamples. RESULTS: We found very complex changes of the power density spectra. We focused our study onto three frequency components. Strong activity increase is seen at low frequencies. Contrariwise, the high frequency part of the spectrum strongly decreases in power with specific rise in characteristic frequencies of the individual components. We discuss various scenarios of this phenomenology as reprocessing of X-rays in a receding accretion disc or a radiation from a more active region at the outer disc. Finally, we show that various cataclysmic variables show similar characteristic frequencies in their power density spectra. These are dependent on activity stage, making the situation similar to X-ray binaries.
Derin Öğrenmede Diferansiyel Mahremiyet

Verinin boyut ve cesitlilik olarak arttigi, kisisel verilerin kolaylikla paylasildigi ve ihlallerinin sayisinin hizla yukseldigi gunumuzde veri mahremiyeti, uzerinde cokca calisilan ve onlemler gelistirilen konularin basinda gelmektedir. Kisisel verileri kullanan, depolayan veya isleyen her turlu uygulama, urun veya sistem, veri mahremiyetini saglamak, korumak ve dogru bir sekilde uygulandigini gostermek zorundadir. Son yillarda veri mahremiyeti kapsaminda pek cok yeni cozumler gelistirilse de teknolojik gelismeler, yapay zekâdaki ilerlemeler, derin ogrenme yaklasimlarinin uygulama basarisi, bu yaklasimlarin pek cok alanda kullanilmaya baslanmasi ve yapisi itibariyle kara-kutu cozum saglamasi, veri mahremiyeti acisindan yeni endiseleri de beraberinde getirmistir. Bu calismada, gunumuzun onemli yapay zekâ teknolojilerinden biri olan derin ogrenmede, kisisel bilgi iceren verilerin analiz edilmesi surecinde mahremiyet koruyucu cesitli onlemler incelenmis, bu onlemlerden en cok kullanilani olan diferansiyel mahremiyet aciklanmis ve derin ogrenmedeki uygulamalari ve tehditler karsilastirilmistir. Sunulan bu calismanin, kisisel verileri isleyen derin ogrenme tabanli uygulamalarda, olusabilecek ihlallerin onlenmesine, karsilasilabilecek risklerin dogru belirlenmesine ve gereken onlemlerin daha saglikli alinmasina katki saglayacagi degerlendirilmektedir.
Blood group reckoning: Unraveling the mystery of blood group antigens

Corresponding author Dr. Mehnaaz Sameera Arifuddin DOI: https://doi.org/10.23921/amp.2018v2i4. 23002 Associate Professor Print ISSN: XXXX-XXXX Department of Physiology, Deccan College of Medical Sciences, DMRL ‘X’ Road, Kanchanbagh, Hyderabad-500058, Telangana, India. Online ISSN: 2456-8422 Copyright © 2018. Quench Academy of Medical Education and Research (QAMER). Phone: +91-9963850393 This is an open access article licensed under a Creative Commons Attribution 4.0 International License. Email: mehnaaz@deccancollegeofmedicalsciences.com
Learning 2-in-1: towards integrated EEG-fMRI-neurofeedback

Neurofeedback (NF) allows to exert self-regulation over specific aspects of one’s own brain function by returning information extracted in real-time from brain activity measures. These measures are usually acquired from a single modality, most commonly EEG or fMRI. EEG-fMRI-neurofeedbaek (EEG-fMRI-NF) is a new NF approach that consists of providing a NF based simultaneously on EEG and fMRI. By exploiting the complementarity of these two modalities, EEG-fMRI-NF opens a spectrum of possibilities for defining bimodal NF targets that could be more ro-bust, flexible and effective than unimodal ones. However facing a greater amount of information, the question arises of how to represent the EEG and fMRI features simultaneously in order to allow the subject to achieve better self-regulation. In this work, we propose that the EEG and fMRI features should be represented in a single bimodal feedback, which we refer to as integrated feedback. We then introduce two integrated feedback strategies for EEG-fMRI-NF and compare their early effects on a motor imagery task with a between-group design. The first group (BI DIM, n=10) was shown a two-dimensional (2D) feedback in which each dimension de-picted the information from one modality. The second group (UNI DIM, n=10) was shown a one-dimensional (1D) feedback that integrated both types of information even further by merging them into one. Online fMRI activations were significantly higher in the UNI DIM group than in the BI DIM group, which suggests that the 1D feedback is easier to control than the 2D feedback. However when looking at posthoc activation levels, the difference of fMRI activation levels between the NF runs and the preliminary motor imagery run without NF was more significant in the 2D group. Moreover, subjects from the BI DIM group produced more specific BOLD activations with a notably stronger activation in the right superior parietal lobule (BI DIM > UNI DIM, p < 0.001, uncorrected). These results suggest that the 2D feedback encourages subjects to explore their strategies to recruit more spe-cific brain patterns. To summarize, our study shows that 1D and 2D integrated feedbacks are effective but also appear to be complementary and could therefore be used in combination in a bimodal NF training program. Altogether, our study paves the way to novel integrated feedback strategies for the development of flexible and effective bimodal NF paradigms making the most of the bimodal information and better suited to clinical applications.
Decentralized SDN Control Plane for a Distributed Cloud-Edge Infrastructure: A Survey

Today’s emerging needs (Internet of Things applications, Network Function Virtualization services, Mobile Edge computing, etc.) are challenging the classic approach of deploying a few large data centers to provide cloud services. A massively distributed Cloud-Edge architecture could better fit these new trends’ requirements and constraints by deploying on-demand infrastructure services in Point-of-Presences within backbone networks. In this context, a key feature is establishing connectivity among several resource managers in charge of operating, each one a subset of the infrastructure. After explaining the networking management challenges related to distributed Cloud-Edge infrastructures, this article surveys and analyzes the characteristics and limitations of existing technologies in the Software Defined Network field that could be used to provide the inter-site connectivity feature. We also introduce Kubernetes, the new de facto container orchestrator platform, and analyze its use in the proposed context. This survey is concluded by providing a discussion about some research directions in the field of SDN applied to distributed Cloud-Edge infrastructures’ management.
Development of marama bean, an orphan legume, as a crop

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2019 The Authors. Food and Energy Security published by John Wiley & Sons Ltd. on behalf of Association of Applied Biologists. 1Department of Biology, Case Western Reserve University, Cleveland, Ohio 2Formerly Rothamsted Research, Harpenden, UK 3Department of Natural and Applied Sciences, Namibia University of Science and Technology, Windhoek, Namibia 4Mulungushi University School of Agriculture and Natural Resources, Kabwe, Zambia 5Department of Plant and Soil Sciences, Forestry and Agricultural Biotechnology Institute, University of Pretoria, Pretoria, South Africa
Study on the scheme‐design framework and service‐business case of product service system oriented by customer value

As the market competition is becoming fierce, to obtain long-term profits for manufacturing enterprises, under the high-frequency dynamic customer needs (CNs), many manufacturing enterprises have to transform from product manufacturers to industrial product–service providers. The product–service system (PSS) is the key to spur manufacturing companies to move from the design and production of a single product to the design and manufacture of an overall solution (including products and services). Because of the shortcomings of the current research, a customer value-oriented PSS overall scheme-design framework is proposed. On this basis, a customer value hierarchy model, value model, function model, and scheme model are established. The multi-level mapping of CNs information to product–service solutions was realised, and the leading key technologies of scheme design of the PSS were proposed. Finally, according to the different scheme-design implementation models, various service-business cases are analysed, which can provide a reference value for the research of the scheme design of the PSS.
The Hedonic Method in Evaluating Apartment Price: A Case of Ho Chi Minh City, Vietnam

The study examines factors affecting apartment prices in the real estate market of Ho Chi Minh City, Vietnam. The study uses primary data based on surveys of customers who have traded successfully, and collects transaction data from real estate trading companies that are the top investors in Ho Chi Minh City real estate market. The collected data include 384 observations in a total of 24 districts, detailing that each district surveyed on a minimum of four projects, each project carried out a survey on a minimum of four apartments. The survey collected 339 valid questionnaires for analysis and model testing. This study employs multivariate regression with the data of 339 observations. The research results reveal that five significant factors affect positively the price of apartments in Ho Chi Minh City – apartment area, toilet and bedroom, apartment floor, reference price, and apartment interior. Besides, there are three significant factors affecting negatively the price of apartments – next price trend, distance to city center, and potential building. From the results, the research proposes solutions in the pricing of apartments in the real estate market in Ho Chi Minh City – better information system, a real estate transaction index, and stricter management of small brokerage activities.
Central Heating Cost Optimization for Smart-Homes with Fuzzy Logic and a Multi-Agent Architecture

Recent years have defined the need to reduce gas emissions to fight climate change, and society’s move to green energies is important to make responsible use of non-renewable energies. Therefore, it is now important to use technologies to optimize the use of actual energy sources. In this aspect, the Internet of Things (IoT) technology has had a great impact on society. Hence, this research work aims to use IoT technology and multi-agent systems to optimize the use of central heating installation in buildings. It is intended to improve the user’s comfort, reduce the consumption of energy and reduce the financial costs. Therefore, a multi-agent system is proposed to collect data from sensors located in a smart-home and obtain the best action to perform in a central heating system. The decisions will be taken by an intelligent agent based on fuzzy logic. This technology will allow for generating the control action with a fuzzy controller. The results obtained show that the proposal improves the actual system in terms of users’ comfort and financial and energy savings.
Selenium Content in Spelt, Buckwheat, and Vegetable Pasta

Аннотация. Введение. Селен относится к микроэлементам, который участвует в работе антиоксидантной системы защиты организма человека и обладает иммуномодулирующим действием. В организме человека селен входит в состав 30 биологически активных соединений. Дефицит селена считается глобальной проблемой. Целью данного исследования являлось определение содержания селена в разработанных макаронных изделиях. Объекты и методы исследования. Лабораторные образцы макаронных изделий из смеси цельнозерновой полбяной муки с добавлением гречневой муки и порошков низкотемпературной сушки брокколи и сельдерея. Определение содержания селена выполнено методом атомно-абсорбционной спектроскопии с электротермической атомизацией с модификатором матрицы палладий азотнокислый на атомно-абсорбционном спектрофотометре Hitachi 180-80. Определение содержания селена выполнено после мокрой минерализации образцов в азотной и хлорной кислотах с добавлением перекиси водорода и этанола для переведения селена из неорганических и органических форм в селенит-ион. Результаты и их обсуждение. Установлено, что применяемые компоненты являются богатым источником селена. Поэтому их можно использовать в рецептурах продуктов с функциональной направленностью. Содержание селена в образцах составило от 105,7 ± 22 мкг/кг до 302,5 ± 17 мкг/кг. С учетом потерь селена при варке макаронных изделий содержание селена в 100 г продукта составило 13,5–38,5 %. Выводы. Разработанные макаронные изделия являются источниками селена. Использование гречневой муки и овощных порошков в рецептуре макаронного теста из цельнозерновой полбяной муки повысило содержание селена в макаронных изделиях на 40,7–186,2 %. Полученные в данном исследовании результаты могут использоваться для таблиц химического состава российских продуктов питания.
Professional Self-Identification of Future Educators as a Form of Personal Growth

The article covers the issue of professional self-identification of future specialists. The meaning of the concept of “self-identification” has been revealed, the circle of related concepts highlighted, and the process of self-identification in the context of personal self-determination analyzed. The purpose and objectives of the study have led to the need for a comprehensive use of the basic general scientific methods which are interchangeable at different stages of study. Among them, we should point out theoretical methods (scientific analysis, comparison, systematization, classification, integration of information obtained from psychological, pedagogical literature to design the scholarly apparatus of the study) and empirical research methods (diagnostic techniques: observation, surveying, testing). Professional self-identification is a very important component in the path of professional development of a would-be specialist, as a future teacher must not only have theoretical knowledge and empirical skills, he must also clearly understand the purpose, objects, means, possible difficulties, prospects of his activity, etc. Based on the psychological and pedagogical analysis of scholarly ideas, the meaning and content of definitions, concepts, and conceptual provisions revealing the specific features of the future educators' professional self-identification have been established. It has been proved that a teacher is one of the most responsible professions; helping people, he must be able to maintain aloofness as well as provide professional assistance, and for this, he requires a high level of professional training. It has been determined that the concept of “professional self-identification” correlates with such currently popular notions as self-determination, self-actualization, self-fulfillment, and self-awareness. The study materials may be applied when preparing the lectures on pedagogical subjects such as Pedagogy, History of Pedagogy, Educational and Developmental Psychology, Methodology of Pedagogical Work.
Implementasi core value di sheraton bali kuta resort

The background of this research stems from the value in Marriott companies carried out by all employees as a guideline in working the Marriott core value. Marriott's core value is the core value o f Marriott's company in running its business. But Marriott's core value has not been fully implemented by employees, even employees have not memorized this core value. The purpose of this study was to determine the implementation and percept ion of employees towards core values at the Sheraton Bali Kuta Resort. The type of data in this study are qualitat ive and quantitat ive data. Data sources are primary and secondary data. Data collect ion techniques are observation, interviews, questionnaires, and documentation. The data analysis technique is descript ive qualitat ive. The sampling technique is proportional stratified random sampling. Determinat ion of samples by simple random sampling. The result of the implementation of core is the implementation of put people first related to theprogram take care, job opportunity, welfare facilit ies and infrastructure, and insurance for associates. Implement persue excellence related to career anddevelopment training programs skill, cross training, and associate awards. Implementation of embrance change related to training and socializat ion of changing t imes and techno logical developments. Implement actions with integrity related to see something, say something. The implementation of serve our world is related to the contribution to nature and the surrounding community. Thepercept ion associate's or employee'sof the core value at the Sheraton Bali Kuta Resort is core value put people first is 3.42 categorized as agreed, core value persue excellence that is 4.2 categorized agree, core value embrance change is 4.29 categorized strongly agree, core value act with integrity is 4.14 categorized agree, and core value serves our world which is 4.03 categorized agree. Obtaining anpercept ion associate or employeerelated to the core value overallof 4,016 in the agreed category. Suggest ions in this research are the management of the Sheraton Bali Kuta Resort always regularly conducts socializat ion related to core values Marriott's.
Incidence of complications following non-watertight dural reconstruction with a non-suturable, absorbable collagen matrix onlay graft in elective cranial surgery

At the conclusion of craniotomy procedures, it is a common practice to reapproximate the dura to mitigate the leakage of CSF. Dural closure also limits muscle and epidural scar tissue from coming into contact with the brain following the operation. Duraplasty occurs by interposing a graft material between the dural defects (secondary closure). Duraplasty materials vary from autologous substances, such as pericranium and fat, to synthetic, such as acellular human dermis or collagen matrix. Closure of dural defects is a necessity after neurosurgical procedures to prevent cerebrospinal fluid (CSF) leakage and to reduce the risk of perioperative infections. In several surgical settings primary closure is technically impossible, e.g. due to coagulation-induced shrinkage or retraction of dura, surgical excision of dura (resection of meningiomas), or dural injury after trauma and therefore reconstruction of the dural defect using a substitute is required. Reconstruction with endogenous material is most common. However, harvesting of periosteum or fascia lata may require extended surgical approach, additional incisions and time intensive suturing. Numerous dura substitutes are currently ABSTRACT
Diurnal variation in freshwater ecoacoustics: Implications for site‐level sampling design

Ecoacoustic methods are increasingly used to monitor the state of populations and ecosystems. In freshwater environments, they present the clear advantages of being non‐invasive, reducing bias, and providing continuous observations instead of only limited sampling snapshots in time. However, similar to standard bioassessment methods, temporal variation and choice of indicators can greatly influence ecoacoustic assessments, highlighting the importance of sampling and analysis design. In this study, we quantified diurnal variation in underwater sound and its effect on sampling regimes for two waterholes in the Einasleigh River, Northern Australia. Recording continuously for 6 days, and subsampling 5 s every 10 min, we found 22 distinct sounds that were emitted by fish, Hemiptera and Coleoptera as well as another 22 of abiotic or unknown origin. Through rarefaction analyses, we found that subsampling the data to 60% of the recorded sound events resulted in capture of most of the 44 identified sound types. Temporal heterogeneity—patchy sound events through time—needs to be considered when maximising detected sound events. Reducing the sampling interval from every 10 min to half‐hourly or hourly had a much greater effect on capturing all sound types compared to the number of days recorded or the length of the recording. Overall, only 10–20% of the sound events need to be annotated for most sound types to be described; for example, restricting analysis of the days recorded to only three and the recording interval to 0.5–1 s. Acoustic indices were dominated by three main event types—a diurnally flowing creek, a nocturnal chorus of Hemiptera, as well as a dawn chorus of terapontid fishes. We conclude with two key messages: First, a select group of informative signals can be monitored using very simple methods—namely, converting an audio stream into indices using freely available software. Second, however, to detect less acoustically dominant sound events, manual annotation or single call processing will still be needed. While these findings are encouraging, similar analysis will need to be conducted within other freshwater ecosystems before general conclusions about optimal sampling regimes can be drawn.