Miracle-dz/UniFAR-FTUs huggingface dataset:
The multinational Men's Attitudes to Life Events and Sexuality (MALES) study: I. Prevalence oSf erectile dysfunction and related health concerns in the general population

Objective: The aims of the Men's Attitudes to Life Events and Sexuality (MALES) study were to identify prevalence of erectile dysfunction (ED) and related health issues in the general male population in Europe, North and South America, and to examine the attitudes and behavior of men in relation to these health issues. Research design and methods: Phase I of the MALES study involved 27839 men aged 20-75years who were interviewed in eight countries (United States, United Kingdom, Germany, France, Italy, Spain, Mexico, and Brazil) using a standardized questionnaire. Phase II of the MALES study involved 2912 men who were recruited from the sub-sample of Phase I MALES participants who reported ED together with additional men with ED recruited from other sources. Main outcome measure: Prevalence of ED and associated attitudes. Results:The overall prevalence of ED in the MALES sample was 16%. ED prevalence varied markedly by country, however, from a high of 22% of men in the US reporting ED to a low of 10% in Spain. The prevalence of self-reported ED increased with increasing age. Men with co-morbid medical conditions and risk factors, including cardiovascular disease, hypertension, dyslipidemia, and depression all reported higher prevalence of ED. Men with ED also reported increased prevalence rates of these co-morbid conditions. MALES Phase II data indicated that among men who reported ED, 58% had actively sought medical attention for their condition; however, only 16% of men with ED were currently being treated with oral PDE-5 therapy. Conclusions: The MALES study confirms the high prevalence rates of ED and its association with co-morbid medical conditions, such as diabetes and depression, reported in other large-scale, epidemiological studies. Despite the advent of oral phosphodiesterase inhibitors, only 58% of ED sufferers consult a physician about their problem, and only 16% of men with self-reported ED maintain their use of oral therapy.
Wavelet Support Vector Machine Algorithm in Power Analysis Attacks

Template attacks and machine learning are two powerful methods in the field of side channel attacks. In this paper, we aimed to contribute to the novel application of support vector machine (SVM) algorithm in power analysis attacks. Especially, wavelet SVM can approximate arbitrary nonlinear functions due to the multidimensional analysis of wavelet functions and the generalization of SVM. Three independent datasets were selected to compare the performance of template attacks and SVM based on various kernels. The results indicated that wavelet SVM successfully recovered the offset value of the masked AES implementation for each trace, which was obviously 5 to 8 percentage points higher than SVM-RBF. And also, the time required was almost reduced by 40% when using the optimal parameters of wavelet SVM. Moreover, wavelet SVM only required an average of 5.4 traces to break the secret key for the unmasked AES implementation and less than 7 traces for the masked AES implementation.
Corticosteroids can reverse severe imatinib-induced hepatotoxicity.

BACKGROUND Imatinib can induce severe hepatotoxicity, in 1-5% of CML patients, many of whom need permanent imatinib discontinuation. DESIGN AND RESULTS We report 5 CML patients who developed grade 3-4 hepatotoxicity after 2-8 months in imatinib. Different aetiologies of liver damage were ruled out and toxicity recurred in 2 patients with further attempts at low dose imatinib. In all patients prednisone or methylprednisolone at 25- 40 mg/day resolved hepatotoxicity in 3-8 weeks and allowed imatinib to be resumed at full doses. Corticosteroid were tapered off in 3-5 months without hepatotoxicity recurrence. CONCLUSIONS Corticosteroid may avoid discontinuation for hepatotoxicity of the most effective anti-CML therapy.
Dual-band stepped-impedance filters for ultra-wideband applications

New ultra-wideband planar dual-band filter designs are presented. Two broad passbands with up to 48 percent fractional bandwidths are obtained by utilizing quarter- wavelength coupled-line section to create additional reflection zeros within each passband. Parallel open-end high impedance segments in stepped-impedance resonators achieve passband separation as they provide attenuation poles between the passbands. Out-of-band rejection is improved by introducing source-load coupling, which produces attenuation poles in the lower and higher rejection bands. The basic design approach is discussed. Several different dual ultra-wideband filters are proposed. Two different professional EM software packages verify the individual responses.
Infant Formula, Tea, and Water Supplementation of Latino Infants at 4-6 Weeks Postpartum

The American Academy of Pediatrics recommends exclusive breastfeeding until 6 months-of-age. The authors examined prevalence and risk factors for use of infant formulas, water, and teas at 4-6 weeks in Latino infants in the San Francisco Bay Area, a group at high risk for future obesity. They recruited a cohort of pregnant Latina women (N = 201). Infant dietary recall and postpartum depressive symptoms were assessed at 4-6 weeks. The authors found that 105 women (53.1%) were feeding infant formulas and 48 (25.4%) were supplementing with tea or water. Of those providing water or tea, 60.0% were providing daily supplementation. In multivariate analyses, risk for infant supplementation with water or tea was associated with postpartum depressive symptoms (relative risk, 1.8; 95% confidence interval, 1.1-3.0), cesarean delivery (relative risk, 1.9; 95% confidence interval, 1.3-2.9), and infant formula use (relative risk, 1.3; 95% confidence interval, 1.1-1.6). Early supplementation with water or teas and infant formulas should be discouraged in Latinos, given the high frequency observed in this population.
Neural mechanisms involved in odor pleasantness and intensity judgments

Olfactory processing in the human brain was examined using positron emission tomography. Twelve normal volunteers were scanned while smelling pairs of odors: they were asked to judge which odor was more pleasant in one condition, and which was more intense in a second condition; they also were scanned while sniffing an odorless stimulus. As in prior studies, greater cerebral blood flow was found in the right orbitofrontal cortex during both pleasantness and intensity judgments as compared to baseline. Cerebellar activity was also seen, but contrary to expectations no activity was detected in the primary olfactory (piriform) cortex. Only the pleasantness judgment elicited additional activity within the hypothalamus, suggesting that this structure may be involved in affective processing that requires access to information about internal state.
Programmed aortic dysfunction and reduced Na+,K+‐ATPase activity present in first generation offspring of lard‐fed rats does not persist to the second generation

We have previously reported that male and female offspring of Sprague–Dawley rats fed a diet rich (approximately 50% of caloric intake from fat) in animal fat (lard) during pregnancy and suckling (OHF) demonstrate cardiovascular dysfunction, including blunted endothelium‐dependent vasodilatation in the aorta as well as reduced renal Na+,K+‐ATPase activity. Cardiovascular dysfunction has been reported in other models of developmental programming and some researchers describe transmission from F1 to F2 generations. Here we report a study of vascular function, as assessed in isolated rings of aorta mounted in an organ bath, and renal Na+,K+‐ATPase activity in 6‐month‐old male and female F2 offspring of lard‐fed and control‐fed (OC) dams (n= 13 per diet group). An increase in brain (OC 0.61 ± 0.01%versus OHF 0.66 ± 0.02% of bodyweight) and kidney weights (OC 0.32 ± 0.01%versus OHF 0.37 ± 0.01% of bodyweight) was observed in female F2 offspring of lard‐fed dams compared with F2 controls (P < 0.03). Constrictor responses to phenylephrine in the aorta were not different from F2 controls (repeated measures ANOVA, P= 0.85). Also, endothelium‐dependent dilator function, as assessed by responses to acetylcholine (repeated measures ANOVA, P= 0.96) and passive distensibility in the absence of extracellular calcium (repeated measures ANOVA, P= 0.68), was similar. Additionally, renal Na+,K+‐ATPase activity was not statistically different from that observed in control animals (ANOVA, P= 0.89). Although a maternal diet rich in animal fat has deleterious effects on parameters of cardiovascular risk in F1 animals, it does not appear that disorders previously reported in the F1 generation are transmitted to the F2 generation.
THE ROLE OF NITRIC OXIDE (NO) AND STATINS IN ENDOTHELIAL DYSFUNCTION AND ATHEROSCLEROSIS

Vascular endothelium plays an essential role in the regulation of the vascular tone, contributing to maintaining the balance between vasodilatation – vasoconstriction, owing to the production of endogenous nitric oxide (NO) under the action of different endogenous and exogenous factors. The loss of the functional integrity of the vascular endothelium, called endothelial dysfunction, in different hearth diseases, is associated with the damage of NO production. Atherosclerosis, an inflammatory chronic disease, is characterised from the beginning through leukocytes adhesion to the vascular endothelium, the first step of endothelial dysfunction in atherosclerosis. Statins, recently introduced in the therapy for lowering the cholesterol level, through this effect and also the pleiotropic effects, improve the endothelial dysfunction through the increase of endogenous production of NO in different pathways. Rezumat Endoteliul vascular joacă un rol cheie in reglarea tonusului vascular contribuind la menţinerea unui echilibru intre vasodilataţie – vasoconstricţie, datorită producţiei endogene de oxid nitric (NO) sub acţiunea diferiţilor factori endogeni si exogeni. Pierderea integrităţii funcţionale a endoteliului vascular, denumită disfuncţie endotelială, in diferite boli cardiovasculare, este asociată cu pierderea capacităţii de producţie a NO. Ateroscleroza, afecţiune inflamatorie cronică, se caracterizează de la inceput prin adeziunea leucocitelor de endoteliul vascular, prim pas al disfuncţiei endoteliale in ateroscleroză. Statinele, recent introduse in terapia hipercolesterolemiei, atât prin efectul de scădere a concentraţiei colesterolului, cât si prin asa numitele efecte pleiotrope ale lor, imbunătăţesc disfuncţia endotelială prin cresterea producţiei endogene de NO prin diferite mecanisme.
Estudo sobre a distribuição dos serviços de reabilitação: o caso do Rio de Janeiro

Norms and regulations from the Brazilian Ministry of Health – MS related to rehabilitation are all concerned with high necessity groups, such as the physically and mentally disabled and the elderly. Taking into consideration that there is no national rehabilitation policy within the assistance organization of the Brazilian Health System – SUS, the main objective of this paper is to critically analyze national directions and norms that deal with this matter and evaluate their impact on the services provided in the State of Rio de Janeiro, Brazil. To achieve this goal, a survey within the technical areas of MS has been carried out, focusing on norms, concepts, directions, actions and the policies from SAS/MS 303/92; 305/92; 304/92; 306/92; 185/01; 116/93; 146/93 and GM/MS 818/01; 1.531/01; 1.395/99 702/02; 249/02; 738/02; 1.635/02; 189/02; 336/02, all related to rehabilitation as their main concern. On the sequence, it has compared the quantity of rehabilitation services provided by the State of Rio de Janeiro, which are connected to the SUS, with the population necessity, as shown by the Brazilian Institute of Geography and Statistics – IBGE, ministry recommendations and service allocation within the cities of Rio de Janeiro and Niteroi. Mental health services are overestimated, representing about 81% of all rehabilitation services. There is a deficit of visual and physical rehabilitation services, as well as services specialized on the elderly, and there are no hearing rehabilitation services at all. As such, this research aims at showing the necessity to, not only create new standards, but also have the present norms work together, so as to make available a national rehabilitation policy that will contribute to and make easier the planning of services based on the epidemiological necessities of the population.
Stochastic Ageing and Dependence for Reliability

This book aims to introduce simulation techniques for practitioners in the financial and risk management industry at an intermediate level. The only prerequisite is a standard undergraduate course in probability at the level of Hogg and Tanis (2005), say, and some rudimentary exposure to finance. It is a hands-on book that has extensive simulation examples using S–PLUS or Visual Basics. The book contains 10 chapters. The chapters are organized into three parts. Part one consists of the first three chapters, part two covers Chapters 4–6, and part three consists of the rest of the book. Throughout the book, hands-on examples and case studies from finance and risk management are incorporated. Almost all of the examples and case studies are illustrate with S–PLUS and some with Visual Basics. Readers can reproduce the analysis and learn about either S–PLUS or Visual Basics by replicating some of the empirical examples.
Prolonged effect of calcium supplementation on risk of colorectal adenomas in a randomized trial.

BACKGROUND Calcium supplementation has been shown to decrease the risk of recurrence of colorectal adenomas in randomized trials. However, the duration of this protective effect after cessation of active supplementation is not known. METHODS In the Calcium Polyp Prevention Study, 930 subjects with a previous colorectal adenoma were randomly assigned from November 1988 through April 1992 to receive placebo or 1200 mg of elemental calcium daily for 4 years. The Calcium Follow-up Study was an observational phase of the trial that tracked adenoma occurrence for an average of 7 years after the end of randomized treatment and gathered information regarding the use of medications, vitamins, and supplements during that time. We obtained follow-up information for 822 subjects, 597 of whom underwent at least one colonoscopy after the end of study treatment and are included in this analysis. Generalized linear models were used to compute relative risks (RRs) and 95% confidence intervals (CIs) for the effect of randomized calcium treatment on risk of adenoma recurrence during the first 5 years after study treatment ended and during the subsequent 5 years. Statistical tests were two-sided. RESULTS During the first 5 years after randomized treatment ended, subjects in the calcium group still had a substantially and statistically significantly lower risk of any adenoma than those in the placebo group (31.5% versus 43.2%; adjusted RR = 0.63, 95% CI = 0.46 to 0.87, P = .005) and a smaller and not statistically significant reduction in risk of advanced adenomas (adjusted RR = 0.85, 95% CI = 0.43 to 1.69, P = .65). However, the randomized treatment was not associated with the risk of any type of polyp during the next 5 years. The findings were broadly similar when the analysis was restricted to subjects who did not report use of any calcium supplements after the treatment phase of the trial ended. CONCLUSION The protective effect of calcium supplementation on risk of colorectal adenoma recurrence extends up to 5 years after cessation of active treatment, even in the absence of continued supplementation.
Reconfigurable Silicon and Germanium Nanowire Electronics – From Multifunctional Devices to Circuits

Semiconductor nanowire transistors are considered potential successors of finFETs providing the ultimate miniaturization capabilities of MOS transistors targeting an even higher circuit complexity and performance. A promising perspective for further advancement beyond classical CMOS scaling is to exploit functionality enhancement of the elementary computing units. Several nanowire based multi-gated device concepts known as reconfigurable field effect transistors (RFETs) [1,2] and polarity control (PC) FETs [3] that combine multifunctionality with the inherent advantages of silicon nanowires are being currently evaluated. These four-terminal devices merge unipolar nand pFET switching characteristics from the same device as selected simply by an electric signal and without the need for doping enabling complementary CMOS operation with a single kind of transistor. RFETs make use of two sharp metal-NiSi2 / intrinsic-silicon interfaces with individual gates for the selective injection of electrons and holes into the channel region [4]. In order to allow complementary circuit operation symmetry in the pand n-type I-V characteristics is mandatory. To this end, the application of radially compressive strain to <110> oriented silicon nanowires is able to align the injection efficiency of electrons and holes [5]. Full swing complementary operating circuits are shown with symmetric RFETs [6]. Multi-functionality is used to synthesize logic circuits with lower transistor count reducing critical pathes and power consumption as compared to conventional CMOS [7,8]. We will further analyze the prospects of Ge based RFETs for performance enhancement.
Integrin expression on chondrocytes: correlations with the degree of cartilage damage in human osteoarthritis.

OBJECTIVE To verify the distribution of different types of beta 1 integrin on the plasma membrane of chondrocytes and to correlate the pattern of integrin expression to the severity of osteoarthritis (OA). METHODS The articular cartilage of ten OA patients who had undergone surgical knee replacement for "genu varum" were studied. The cartilage was separated into three zones that macroscopically and microscopically showed a decreasing degree of anatomic lesions. After enzymatic digestion, the isolated chondrocytes were immediately challenged with monoclonal antibodies against the beta 1, alpha 1-6 and alpha v chains. The phenotypic study was paralleled by a cell cycle analysis performed by flow cytometry on chondrocytes stained with propidium iodide. RESULTS Chondrocytes isolated from the articular cartilage of osteoarthritic patients expressed, in different percentages, all the alpha chains (alpha 1-6 and alpha v) of the beta 1 integrins. The alpha chain most frequently expressed was alpha 1, followed by alpha 3, alpha 5, alpha 2 and alpha v, with lesser amounts of alpha 4 and alpha 6. The beta 1 chain was expressed (on average) on the 40% of the chondrocytes regardless of the zone they were isolated from. Differential phenotypic analysis of the three zones showed that beta 1 integrins correlate inversely with the severity of the anatomic lesions and the cycle phase of the chondrocytes (the G0/G1 phase prevailed in the anatomically normal cartilage of the least damaged zone, and the S-phase in the most damaged zone). CONCLUSIONS This study provides evidence of the existence of beta 1 integrins on the surface of chondrocytes from human OA cartilage, all of the alpha chains being represented, although in different percentages. Moreover, an inverse correlation was demonstrated between the severity of the anatomical changes found in the zones and the phenotypic/metabolic changes of the cells. These results, together with the well known inside-out signaling function of the adhesion molecules, highlight the key role of matrix interactions in the pathogenesis of the anatomic changes in OA.
Investigate and Control of Power Transformer Noise

The importance and recent achievements in the field of noise control of power transformer are expounded in this paper. Oscillation is presented as the reason for the transformer and cooling system noise. The methods used in transformer noise research are summed up. Generally speaking, far-field radicalization noise can be analyzed by summing up statistic data and setting calculating model, and sound intensity method is more accurate in measuring noise level of a transformer compared with traditional sound pressure method. The measures for controlling the transformer noise are introduced in detail. High-quality silicon-steel is suggested to be used, as well as adopting some effective measures when design, machining and install transformers. Assuasive equipments, muffler, sound insulation board and isolation booth, which will result attenuation in noise transmission, are proposed in order to reducing noise. Lastly but not the least important, opinions on the trend of the transformer noise control are bring forward.
Algorithme primal-dual de points intérieurs pour l'estimation pénalisée des cartes d'abondances en imagerie hyperspectrale

L'estimation des cartes d'abondances en imagerie hyperspectrale necessite de resoudre un probleme d'optimisation sous des contraintes de positivite et d'additivite. Nous nous placons dans le cadre ou les spectres des composants presents au sein de l'image ont ete prealablement estimes par un algorithme d'extraction des poles de melange. Afin de reduire le temps de calcul, nous proposons un algorithme rapide de points interieurs de type primal-dual pour l'estimation de ces cartes. En comparaison avec la methode de reference FCLS, l'algorithme propose presente l'avantage d'un cout de calcul reduit. Un second avantage est de pouvoir traiter le cas d'un critere penalise favorisant la regularite spatiale des cartes d'abondances. Des exemples sur des donnees synthetiques et reelles illustrent les performances de cet algorithme.
An environment for exploring low power memory configurations in system level design

Presents an environment for the exploration of low-power memory configurations. The environment uses accurate models of memory energy, area and delay to evaluate different configurations. Taking the constraints specified by the user and memory profiling information from the application, the environment can optimize the memory organization for a specific application. The environment also places and routes the organizations to provide more accurate energy, area and delay estimates. Our overall memory system estimation is highly accurate, with average absolute percentage errors within 7%. Within the environment, the user can explore powerful energy/area/delay trade-offs. We present results which show energy reductions within the memory system of up to 63%.