Miracle-dz/UniFAR-FTUs huggingface dataset:
Design of Function Signal Generator Based on DDFS

The system is designed to construct a Function Signal Generator based on Direct Digital Frequency Synthesis Technology (DDFS), in which MCU and FPGA are the key components and necessary peripheral circuits are provided. Its main modules are responsible for the formation of oscillogram, the frequency synthesis, the digital-to-analog transformation, the control of range, and back-stage treatment, the user interface and other necessary modules. MCU controls FPGA to generate the oscillogram and other control words, and the FPGA controls output waveform and frequency synthesis. Amplitude control is realized by 2 DA. Low-pass filter and Transistor push-pull power amplification circuit are used to increase the quality of the output waveform and its loading capacity, and display the signal on the LCD. The system constitutes of 2 DAC and the FPGA, so that realizes the expanded requirements of 1 Hz-1MHz of the four waveform output.
Food Habits, Weight Status and Metabolic Risk Factors in a Group of Adults in Tehran

Background and Objectives: This study was carried out to assess food habits and their associations with weight status and metabolic risk factors in adults in Tehran, Capital of Iran. Materials and Methods: A cross-sectional survey was conducted in a sample of adults (n=227) over 18 years old residing in Tehran. Demographic, anthropometric and food frequency questionnaires were filled out for all of the participants. Food habits were recorded using dietary habit questionnaires. Serum concentrations of glucose and lipids (total cholesterol [TC], triglycerides [TG] and high-density lipoprotein-cholesterol [HDL-C]) were analyzed from fasting blood samples. Results: The mean body mass index (BMI) was 28.52 kg/m and a minority of the participants (22.2%) had normal BMI. The participants rarely used table salt, fast food and crispy foods, dined at restaurants and had two snacks, three or more meals a day, five or more breakfast episodes a week and regular meals. They used vegetable oils for cooking and frying and/or cooking oil for frying. Drivers (p < 0.001) and less educated participants (p= 0.012) were susceptible to overweight. Positive associations were found between the BMI and the participant age (rs =0.28, p<0.001) and serum glucose (rs = 0.22, p =0.005), TG (rs = 0.34, p< 0.001) and TC (rs = 0.36, p < 0.001). Participants with normal weights had regular meals (p= 0.034) and frequent snacks (p = 0.048). Overweight and obese participants had a higher rate of dyslipidemia (serum TG ≥ 150 mg/dL), compared to that of the normal weight participants (18.0 and 35.0% vs.7.9%, p=0.004). Conclusions: The present participants had relatively healthy food habits, except for the order of meals and saturated fat consumptions. This study confirms the associations between overweight/obesity and dyslipidemia. Nutrition education with emphases on regular meals and frequent snacks (as protective habits against obesity) is recommended, especially for susceptible groups.
Validation of an Immune-Related Gene Pair Index as a Prognostic Marker of Lung Squamous Cell Carcinoma

Background: Lung squamous cell carcinoma (LUSC) is one of the subtypes of non-small-cell lung cancer (NSCLC) and accounts for approximately 20 to 30% of all lung cancers. Methods: In this study, we developed an immune-related gene pair index (IRGPI) for LUSC from 8 public LUSC data sets, including The Cancer Genome Atlas LUSC cohort and Gene Expression Omnibus data sets, and explored the prognostic value of IRGPI for patients with LUSC. Results: IRGPI was constructed by 13 gene pairs consisting of 25 unique immune-related genes from the training cohort. Multivariate cox regression analysis showed that high risk based on IRGPI was an independent risk factor for poor prognosis of patients with LUSC in the training cohort (230 patients; HR= 3.40; 95%CI [2.34-4.94]; p<0.001), the testing cohort (228 patients; HR=2.11; 95%CI [1.48-3.01]; p<0.001) and the validation cohort (472 patients; HR=1.99; 95%CI [1.5-2.63]; p<0.001). The infiltrations of naïve B cells, plasma cells, CD8+ T cells, activated memory CD4+ T cells, gamma delta (γδ) T cells, M1 macrophages, and activated dendritic cells were lower in the high-risk group, as compared with the low-risk group in the TCGA cohort. The infiltrations of neutrophils, activated mast cells, and monocytes were higher in the high-risk group. Conclusions: IRGPI is a significant prognostic biomarker for predicting overall survival in LUSC patients. Combining clinical features with IRGPI will improve prognostic accuracy.
PROPOSTA DE MELHORIA NO PROCESSO DE COMBATE À CRIMINALIDADE NA CIDADE DO RIO DE JANEIRO

Crime rates in large urban centers have intensified in recent years due to population growth and lack of infrastructure in cities. In parallel, information technology, mobile devices and sensors are leveraging a new paradigm where a large volume of data has been generated. Given that there is a timid advance in public management integration practices, decisions often take place in an inarticulate and imprecise manner. The objective of this paper is to propose improvements in the process of combating crime in the city of Rio de Janeiro, suggesting the use of Big Data to collect data, and where this large volume of data underpins the integrated decision making of the management sectors. municipal. The method used for the research involved the theoretical study on the subject and the survey of examples of use of Big Data. From the survey of crime rates in the Tijuca neighborhood in the north of the city of Rio de Janeiro, it is presented a proposal to improve the fight against crime to help the integrated public management and basis for decision making.
Pharmacognostic and phytochemical studies on Plumeria obtusa L.

From last few decades there is an upsurge in the use of herbal medicines all over the world and these herbal drugs should be studied scientifically to develop their monographs to assure their quality. The present research work was an attempt to establish parameters for identification of Plumeria obtusa L. (Fam. Apocynaceae) according to the guidelines of WHO, by studying its morphological and organoleptic characters, detailed microscopic evaluation, histochemical studies, fluorescence analysis, loss on drying, extractive values, swelling index, foaming index and preliminary phytochemical screening of the leaves and flowers. Although conventional, but it is simple, easy and quick way for identification and standardization of herbal substances affordable even in developing countries. This is the first report on pharmacognostic and physicochemical studies on P. obtusa which can be helpful in establishing pharmacopoeial monograph of this plant.
DIAGNÓSTICO DO GRAU DE DESENVOLVIMENTO E DOS FATORES DE IMPACTO NA IMPLEMENTAÇÃO DA INDÚSTRIA 4.0 NO SETOR INDUSTRIAL CATARINENSE

The industrial sector plays a fundamental role in the consolidation of a strong and sustainable economy, functioning as a source of technological advancements and long-term growth. However, in recente years in Brazil, the sector is losing participation in the composition of the Gross Domestic Product (GDP), phenomenon known as deindustrialisation. As an alternative to restore growth in the industrial sector and make it competitive again in a digitized global scenario, are the principles of Industry 4.0. Defended by many scholars as the fourth Industrial Revolution, Industry 4.0, or Advanced Manufacturing, aims to integrate digital information and communication technologies to the productive systems, generating exponential gains throughout the value chain. This work aims to contribute with the digitalization process of the Industry in Santa Catarina, through the current diagnosis of implementation of Industry 4.0 in the industrial sector of the state and the identification of the challenges and opportunities during this process. For this reason, are applied statistical techniques on data from the state of Santa Catarina industries, in the period from March 2017 to May 2017. The results obtained show that many sectors of the state industry are already incorporating the technologies of the Industry 4.0 to its productive process, such as Big Data and Internet of Things. It was also identified the high cost of initial investment, the lack of IT infrastructure and the lack of skilled labor as the main obstacles to Industry 4.0 in the state. These findings may help the industrial sector of the Santa Catarina state to take more effective measures in aid to companies during this industrialisation process that, in many countries, is already quite well established.
ON THE HIERARCHICAL LEVELS OF DESIGN KNOWLEDGE

Abstract Hierarchies of knowledge represent a popular formalism for conceptualizing beliefs, justifications, and truth statements. To capitalize on the opportunity for formulating effective maps of design knowledge, this article introduces the hierarchical context–design development–high-level (CDH) model that stratifies different bodies of design-specific knowledge into ranked levels. We compare it with existing hierarchical models of knowledge, and describe its unique uses and benefits for both design research and design practice.
EXPLORING CHALLENGES WITH DESIGNING AND DEVELOPING SHORE CONTROL CENTERS (SCC) FOR AUTONOMOUS SHIPS

The concept of remotely operated, unmanned, and autonomous ships is creating increasing interest in the maritime domain, promising safety, increased efficiency and sustainability. Shore control centers (SCCs) have been proposed to operate such vessels and some industry projects are initiated. This paper aims at bringing knowledge about what a SCC is envisioned to be. It identifies and explores challenges related to designing and developing SCCs through semi-structured interviews with the research community and industry. We discuss tasks, functions and interactions between human and machine.
Survey of knowledge, attitudes and practices of obstetricians and gynecologists about screening for Hepatitis B virus infection among pregnant women in Iran, in 2018

Background: Various screening programs for all pregnant women are presented in the first pregnancy visit to reduce the vertical transmission of Hepatitis B virus (HBV) infection from mother to fetus during labor. Obstetricians and gynecologists are often referred to as a reliable source for health information for pregnant women. The present survey aimed to assess the knowledge, attitudes and practices (KAP) of obstetricians and gynecologists regarding screening for HBV infection among pregnant women in Iran, in 2018. Methods: This KAP study was performed in 200 obstetricians and gynecologists in Iran using the available sampling method. Data were collected using a researcher-made, valid and reliable questionnaire which contained 4 parts, including demographic data (3 questions), knowledge (20 questions), attitude (5 questions), and practice (8 questions). The level of knowledge and practice was evaluated using the Likert score, and attitude was defined as positive or negative. The relation between knowledge, attitude and practice, as well as their relationship with the work experience of obstetricians and gynecologists was evaluated. Results: The mean age of obstetricians and gynecologists was 38.9±3.7 years. The knowledge and practice of obstetricians and gynecologists about the screening for HBV in pregnant women was good, and they had a positive attitude on this. There was a direct and significant relationship between knowledge, attitude and practice with each other, as well as between knowledge and lower work experience (P <0.05). Conclusion: Obstetricians and gynecologists play an important and strategic role in the creation and transfer of health information, and the development of preventative measures and control of HBV for pregnant women. Despite the knowledge and attitude of obstetricians and gynecologists being reported at an appropriate level, the moderate level of practice can be alarming.
Predictors of Subjective Wellbeing in Students of Medical Sciences: The Role of Orientation to Happiness and Life Goals

* Corresponding Author: Siavash Talepasand, PhD. Address: Department of Educational Science, Faculty of Psychology and Educational Science, Semnan University, Semnan, Iran. Tel: ±98 (912) 6040690. E-mail: stalepasand@semnan.ac. ir Objective: Subjective wellbeing is a personal experience that points at high levels of positive ‎affections‎and‎life‎satisfaction. ‎The‎relationship‎between‎happiness‎and‎life‎goals‎with‎subjective‎ wellbeing‎provides‎useful‎insight‎into‎the‎prerequisites‎of‎wellbeing. ‎This‎‎study‎aimed‎to‎determine‎ the‎role‎of‎orientation‎to‎happiness‎and‎life‎goals‎in‎predicting‎subjective‎‎wellbeing. ‎
Caenorhabditis Elegans and Tenebrio Molitor - New Tools to Investigate Malassezia Species

Malassezia species are part of human commensal microbiota and is also related to diseases. Little is known about the interaction of these microorganisms with their host. Here we established two standard culture conditions for Malassezia spp. to perform infection assays using C. elegans and T. molitor. Invertebrate hosts infected by Malassezia spp. cultured in M9M resulted in higher death rate on survival assays when compared to yeasts cultured in standard Dixon medium indicating that M9M cultured Malassezia species have increased virulence. The culture and infection conditions established in this work, using invertebrate alternative models, are valuable tools to understand Malassezia-host interaction.
Tryptamines as Ligands and Modulators of the Serotonin 5‑HT2A Receptor and the Isolation of Aeruginascin from the Hallucinogenic Mushroom Inocybe aeruginascens

Aeruginascin is a natural product from the hallucinogenic mushroom Inocybe aeruginascens. This compound was isolated and identified as 4-phosphoryloxy-N,N,N-trimethyltryptamine. Aeruginascin is the quaternary trimethylammonium analog of the hallucinogenic compound psilocybin. Synthetic aeruginascin was identical in all aspects to the isolated sample. Additionally, the mushroom alkaloids norbaeocystin and baeocystin were synthesized and a new synthetic approach to 4‑hydroxy-tryptamines was investigated.In a related project the influence of N-terminal substituents of tryptamines on serotonin receptor binding was studied. A series of tryptamines carrying a broad range of structurally diverse amino-substituents was synthesized. Most compounds had binding affinities in the nanomolar range for the 5‑HT1A, the 5‑HT2A, and the 5‑HT2C receptor. In functional 5‑HT2A IP accumulation assays most ligands acted as antagonists or partial agonists. Several compounds had biphasic dose-response curves. Sometimes the response at higher concentrations exceeded even that of the natural agonist serotonin. As shown by additional experiments, this effect was probably caused by non-competitive positive allosteric modulation of the 5‑HT2A receptor at higher concentrations. These results indicate a new independent regulatory binding site of the 5‑HT2A receptor. In contrast to a previous publication, in our hands the lead compound N‑(4‑bromobenzyl)-5‑methoxy­tryptamine was a low-affinity antagonist at the 5‑HT2A receptor.
Anomaly Detection of Pantograph Based on Salient Segmentation and Generative Adversarial Networks

The pantograph is an important component of railway pantograph-catenary system, which can provide electric current for electrified railway electric locomotive. Since the pantograph is in an open roof environment, the defects of the pantograph are inevitable in the long run. In order to ensure the safe operation of trains, in this paper, we propose a new method for anomaly detection of pantograph based on salient segmentation and generative adversarial networks. First, an object location model is trained by U-Net which perform excellent properties for a small number of samples to accurately extract salient area of the pantograph. Second, a generative adversarial model is constructed to generate the reconstructed salient images of pantograph by vector mapping. Finally, the structural similarity algorithm is used to evaluate the similarity between the input salient image and the reconstructed salient image, so as to extract the image difference and realize the anomaly detection of the pantograph. Experimental results validate the effectiveness and accuracy of our approach.
Estimulación de las funciones ejecutivas y su influencia en el rendimiento académico en escolares de primero básico

El estudio de la estimulación de las funciones ejecutivas (FE) en la infancia ha generado un creciente interés investigativo en la última década, especialmente por su relación con el desempeño académico y éxito escolar. De acuerdo a esto, el presente estudio tiene por objetivo estudiar el efecto de un programa de estimulación de las FE sobre el desempeño ejecutivo y el rendimiento académico de una muestra de 43 estudiantes de primero básico de la comuna de Valparaíso (Chile), de edades entre 6 y 7 años. Para ello, se implementó un diseño factorial mixto. La intervención duró 12 semanas y se llevó a cabo en el aula, dirigida por un educador diferencial y con el apoyo de la profesora del curso. Los resultados evidencian la existencia de un efecto significativo del programa implementado en la mejora del desempeño ejecutivo de los participantes, particularmente del grupo experimental. Tales efectos no fueron replicados en el rendimiento académico, lo que podría encontrar una posible explicación en los factores contextuales relacionados con las condiciones de precariedad de la institución educativa. Se observó además un efecto diferenciado del programa sobre el componente de control inhibitorio. Los hallazgos generales ponen de manifiesto la relevancia de la estimulación de las FE en la infancia temprana y los beneficios que esto puede reportar en contextos educativos. Además, sugiere el potencial aporte de la incorporación de este tipo de intervenciones en las prácticas docentes cotidianas.
Within-host Diversification of Pseudomonas aeruginosa in the Cystic Fibrosis Airways and its Effects on Antimicrobial Resistance

The opportunistic bacterial pathogen Pseudomonas aeruginosa causes fatal pulmonary infections in patients with the genetic disease cystic fibrosis (CF). Phenotypic and genetic diversity are prominent features of P. aeruginosa populations adapting to changes in the lung microenvironment during chronic infection. However, little is known about how this diversity impacts factors such as antimicrobial resistance and patient clinical outcome. Here, we characterized diversity within a P. aeruginosa population from a chronically infected CF patient to identify the extent of phenotypic and genetic change over time. Significant heterogeneity was observed in 34 phenotypes tested among 233 sputum cultured P. aeruginosa isolates from a single study patient, making predictions of an isolate’s phenotypic properties by colony morphology alone difficult. Fluctuations in susceptibility profiles for β-lactam antibiotics over a 350 day period coincided with the emergence of three variant alleles of the penicillin binding protein 3 gene (pbpB). Distinct allele-specific susceptibility patterns for different types of β-lactam antibiotics were not associated with other common mechanisms of resistance. Multiple variant iii alleles of pbpB carrying novel non-synonymous mutations were common among other P. aeruginosa isolated from CF patients with a history of β-lactam treatment. The work described in this thesis demonstrates that P. aeruginosa can behave somewhat unpredictably to antimicrobials in CF infections due to high levels of phenotypic and genetic diversity, and identifies that antibiotic target modification, in the form of penicillin binding protein 3, is a common adaptation among β-lactam exposed P. aeruginosa and may be clinically relevant.
Clinico-Diagnostic Experience with Cervical Lymphadenopathy Patients in a Tertiary Health Care Hospital

Original Research Article This is an observational prospective study, which include 60 patients with cervical lymphadenopathy which came to outpatient department or got admitted in the wards. Clinico-diagnostic profile of these cases was determined. Among 60 cases of cervical lymphadenopathy, females (34, 56.6%) were more than the male (26, 43.3%) patients and most of the patients were at the age group of 21–30 years. Most patients presented with fever (66.1%), weight loss (50%), night sweating (40%), anorexia (46.66%), and cough (30%). 54 (86.66%) cases were diagnosed by fine needle aspiration cytology (FNAC) and 6 (13.3%) were diagnosed by biopsy. 44 (73.33%) had caseous necrosis, 54 (90%) had epithelioid cells, and 16 (26.67%) had giant cells. Previous history of antitubercular therapy (ATT) was present in 20 (33.3%) patients, 16 (26.6) of them took ATT for lymph node TB and 4 (6.66) patients took ATT for pulmonary tuberculosis (TB). 8 (13%) patients has other diagnosis than TB, 4 of them has Hodgkins lymphoma, 2 has other malignancy (carcinoma breast) and 2 has reactive lymphadenitis. Cervical lymphadenopathy can have varied manifestation from non-neoplastic to neoplastic condition. Proper history, examination and relevant investigations and disease specific treatment can only cure the patient and improve the prognosis. Fine-needle aspiration is a safe, easy, accurate, and valuable tool for the evaluation of cervical adenopathy.
Improving e-commerce logistics with Augmented Reality and Machine Learning: The case of the 3D bin packing problem

The volume of activity in e-commerce increases every year. It leads to new challenges on the logistic side to deliver all the goods worldwide in a minimal amount of time. Indeed, the volume of goods delivered by air, sea or land is now gigantic: according to Pitney Bowes (2018), 87 billion of parcels were shipped in 2018. Amazon itself delivers an average of 2.5 billion packages each year (Sheetz, 2019). Alibaba, with the Asian market, has even more customers and targets now Europe with a first European hub in Belgium through a deal struck in 2018. Moreover, customers have grown more demanding in terms of delay. Nowadays it is not uncommon to see the major players offering delivery in less than 24 hours for some destinations and products. This is only possible by optimizing all the elements of the supply chain.
Roof rainwater harvesting as an alternative to mitigate water scarcity in Rwanda

Water scarcity is a problem that affects all developmental aspects, including agriculture, health, education, peace, and economic activities. The state of water scarcity problem is increasing due to the rise of water demand caused by population growth, urbanization, and increase of industrial water usage. The millennium development goals had set targets that were not met, and the on-going sustainable development goals were set to realize the goals. Water is addressed on most of the SDGs goals: clean water and sanitation, life below water, zero hunger, etc. There must be a consideration of investing in the community to harvest rainwater from rooftop to supplement the available water as this can reduce the problems of water scarcity and rainwater runoff that sometimes cause floods, erosion, and landslides. The majority of Rwandese have been experiencing water scarcity problems to the point of weekly or monthly water shortage, and the trend is expected to have an increase due to the projected rapid urbanization. There has been an effort to increase water supply and implementation of the roof rainwater harvesting system by the national government and private sector, trying to help in financial assistance.