Miracle-dz/UniFAR-FTUs huggingface dataset:
THE DEVELOPMENT OF HUMAN RESOURCES IN ORGANIZATIONS

Development of human resources can be one of the main functions of the human resources department. Pat McLagan, using a study, tried to identify the HRD roles and competences required for the effective functioning of HRD. Establishing the need for staff development is the starting point for the preparation, establishing what type of programs is needed and who should attend. This stage also involves the identification of key skills that individuals need in order to perform in their jobs. Career development is a process that characterizes a long period of time, which completely takes over a person's profession, encompassing programs and activities leading to the achievement of individual career plan. It can also be seen as a product of interaction between what the company provides for the employee and his wish to achieve. Employee development methods can be classified in methods directly related to the function (at work) and not directly based methods (outside the workplace). The first category differs from the second in that it is more efficient for staff development because it can be adapted to the preparation, attitude, expectations and responsibilities of each individual.
A comparison of four buprenorphine dosing regimens using open-dosing procedures: is twice-weekly dosing possible?

AIMS To compare opioid withdrawal symptoms during 24-, 48-, 72- and 96-hour buprenorphine dosing regimens and to evaluate subjects' preferences for these different dosing schedules. SUBJECTS Fourteen opioid-dependent subjects participated in this study. They received daily sublingual maintenance doses of 4 mg/70 kg (n = 4) or 8 mg/70 kg (n = 10) of buprenorphine. INTERVENTION In the first study subjects received, in a random order, four dosing regimens for five repetitions of each: daily maintenance doses every 24 hours (4 or 8 mg/70 kg), double the daily maintenance dose every 48 hours (8 or 16 mg/70 kg), triple the daily maintenance dose every 72 hours (12 or 24 mg/70 kg), and quadruple the daily maintenance dose every 96 hours (16 or 32 mg/70 kg). Measures of subjective and observer opioid withdrawal symptoms were assessed prior to receipt of each dose. In a second study, subjects chose between the different dosing regimens. FINDINGS Some withdrawal ratings increased during the less frequent dosing schedules in the first study. In the second study, 46% of subjects preferred the quadruple-every-fourth-day dosing regimen over every other option, and only 14% preferred to be dosed daily. CONCLUSIONS These results suggest that some opioid-dependent outpatients are willing and able to endure the withdrawal symptoms associated with less than daily dosing, and a twice-weekly dosing regimen may be possible.
The Management of a Multicultural Workforce

Human Resource Management and its Significance for International Firms. Origins and Scope of National Culture. Relevance of National Culture for Organisations. Influences of National Culture on Organisations. DEALING AND COPING WITH DIFFERENT NATIONAL CULTURES. Management of Human Resources in a Single Multinational Firm: The Context. Management of Human Resources in a Single Multinational Firm: Thinking Globally, Acting Locally. Management of Human Resources in International Alliances and Joint Ventures. Management of a Multi--Ethnic Workforce in the Same Site. Transferring Management Practices Across Cultures. Concluding Remarks. Index.
Meat quality analysis of Djallonke lambs co-infected with Teladorsagia circumcincta and Trichostrongylus colubrifromis (Trichostrongyloidae) and treated with two medicinal plants

Gastrointestinal nematode infection adversely affects small ruminant productivity all over the world, especially in tropical countries. A study was carried out to evaluate the extent to which concurrent infection with these nematodes may influence lamb meat quality, and how phytotherapy might improve these parameters. During the trial, 24 male Djallonke lambs (Age: 3 to 5 months) were experimentally infected with Teladorsagia circumcincta (4000 infective larvae) and Trichostromgylus colubriformis (10000 infective larvae) and treated from day 26 post infection with methanol extracts of Harungana madagascariensis and Momordica foetida twice daily. Lambs were divided into 8 groups: An untreated (Group 1), Albendazole 7.5 mg/kg (Group 2), H. madagascariensis extract at 125 mg/kg (Group 3), H. madagascariensis extract at 250 mg/kg (Group 4), H. madagascariensis at 500 mg/kg (Group 5), M. foetida extract at 125 mg/kg (Group 6), M. foetida 250 mg/kg (Group 7), and M. foetida at 500 mg/kg (Group 8). Meat quality attributes of lambs from different treatment groups were evaluated. Treatment with different doses of plant extracts led to differences in the level of parasitic load at necropsy. This effect was accompanied by an elevated pH24 in meat from the most severely infected lambs and a concomitant decrease in their chemical composition. This high pH24 equally had significant influence on meat flavour, overall acceptability and water retention of lamb meat. The present study suggested that nematode infection may influence pH of resulting carcass, nutritional composition and some sensory parameters of meat while treatment using M. foetida at 500 mg/kg maybe important in reducing parasite burden while enhancing quality of subsequent lamb carcass. Key words: Phytotherapy, meat quality, Teladorsagia circumcincta, Trichostrongylus colubriformis, Harungana madagascareinsis, Momordica foetida, Djallonke lambs.
Cash Dividend Announcement Effect: Evidence from Dhaka Stock Exchange

The sole motive of the paper is to investigate cash dividend announcement effect of the stocks traded in the Dhaka Stock Exchange from 2006 to 2010. Classic event study methodology was used to analyze the data. It was found that in 2006, 2007 and 2009 market has reacted over the announcement in the event date. Some sectors like Food & Auxiliary, Fuel and Miscellaneous have impacted the market both in the event and post event date across the years considered. All the efforts were given to discover reaction therefore the underlying reasoning of such impact are set aside. Keywords: Cash dividend, Dhaka stock exchange, Event study, Announcement effect
Intimate Partner Violence: An Underappreciated Etiology of Orbital Floor Fractures

Purpose: To evaluate the prevalence of intimate partner violence (IPV) in a large population of female orbital floor fracture patients and provide recommendations on effectively identifying and referring IPV survivors. Methods: Retrospective review of facial fracture patients examined at the University of Iowa Hospitals and Clinics between January 1995 and April 2013. International Classification of Diseases, Ninth Revision, codes and medical record review were used to determine the prevalence of IPV victimization and clinical outcomes. Results: A total of 1,354 women and 4,296 men sustained facial fractures. Of these, 405 women and 1,246 men sustained orbital floor fractures. Leading mechanisms of orbital floor fractures in women were motor vehicle collisions (29.9%) and falls (24.7%). Twenty percent had no etiology documented. Intimate partner violence–associated assault was the third leading documented cause of orbital floor fractures in women (7.6%) followed by non–IPV-associated assault (7.2%). Among women with orbital floor fractures due to assault, leading patterns of injury included the following: isolated orbital floor fractures (38.7%, 12/31 in IPV patients; 55.2%, 16/29 in non-IPV patients), zygomaticomaxillary complex fractures (35.5%, 11/31 in IPV patients; 17.2%, 5/29 in non-IPV patients), and orbital floor plus medial wall fractures (16.1%, 5/31 in IPV patients; 24.1%, 7/29 in non-IPV patients). Involvement of ancillary services was documented in 20.0% (7 law enforcement and 5 social service agencies, 12/60) of assault-related orbital floor fracture cases. Ascertainment of patient safety was documented in 1.7% (1/60) of these cases. Conclusions: Ophthalmologists treating orbital floor fracture patients should maintain a high index of suspicion for IPV and screen accordingly. Following IPV disclosure, patient safety should be assessed and referral provided.
Photoactivated voltage imaging in tissue with an archaerhodopsin-derived reporter

A photoactivated fluorescent voltage sensor protein combines high sensitivity and optical sectioning in tissue. Photoactivated genetically encoded voltage indicators (GEVIs) have the potential to enable optically sectioned voltage imaging at the intersection of a photoactivation beam and an imaging beam. We developed a pooled high-throughput screen to identify archaerhodopsin mutants with enhanced photoactivation. After screening ~105 cells, we identified a novel GEVI, NovArch, whose one-photon near-infrared fluorescence is reversibly enhanced by weak one-photon blue or two-photon near-infrared excitation. Because the photoactivation leads to fluorescent signals catalytically rather than stoichiometrically, high fluorescence signals, optical sectioning, and high time resolution are achieved simultaneously at modest blue or two-photon laser power. We demonstrate applications of the combined molecular and optical tools to optical mapping of membrane voltage in distal dendrites in acute mouse brain slices and in spontaneously active neurons in vivo.
Biomarkers of immunosuppressant organ toxicity after transplantation: status, concepts and misconceptions

Introduction: A major challenge in transplantation is improving long-term organ transplant and patient survival. Immunosuppressants protect the transplant organ from alloimmune reactions, but sometimes also exhibit limiting side effects. The key to improving long-term outcome following transplantation is the selection of the correct immunosuppressive regimen for an individual patient for minimizing toxicity while maintaining immunosuppressive efficacy. Areas covered: Proteomics and metabolomics have the potential to develop sensitive and specific diagnostic tools for monitoring early changes in cell signal transduction, regulation and biochemical pathways. Here, we review the steps required for the development of molecular markers from discovery, mechanistic and clinical qualification to regulatory approval, and present a critical discussion of the current status of molecular marker development as relevant for the management and individualization of immunosuppressive drug regimens. Expert opinion: Although metabolomics and proteomics-based studies have yielded several candidate molecular markers, most published studies are poorly designed, statistically underpowered and/or often have not gone beyond the discovery stage. Most molecular marker candidates are still at an early stage. Due to the high complexity of and the resources required for diagnostic marker development, initiatives and consortia organized and supported by funding agencies and regulatory agencies will be critical.
Barriers to Trade in Health and Financial Services in ASEAN

The purpose of this paper is to give background information on current barriers to trade in four services sectors in the ASEAN region. The information was summarized in a companion paper (Dee 2009), which also laid out concrete proposals for achieving the liberalization targets for these sectors from the ASEAN Economic Blueprint. The four key services are medical services (medical, dental and paramedical services), health services (hospital, medical laboratory and ambulance services), banking services and insurance services. The medical and health sectors are priority sectors under the ASEAN Economic Community Blueprint. This paper describes the survey instruments that were used to collect information about current regulatory policy settings in these sectors in each of the ten ASEAN economies, gives a detailed presentation of results, and compares the results to other recent surveys of services trade barriers in these sectors. In the case of healthcare, there are few comparable cross-country studies, and none that have looked at the evolution of services trade barriers over time. In the case of banking and insurance, by contrast, there have been several previous studies, two of which have looked at how services trade barriers in these sectors have changed over time. In this paper, the most recent information on barriers to financial services trade in ASEAN is also made comparable to that in these other recent studies, so that the current situation in ASEAN can be compared with the recent situation in a number of other developed and developing countries. The findings of the other recent studies on the patterns of financial services liberalization over time are also summarized, as this can give insights into likely patterns of liberalization in ASEAN.
Quantitative analysis of texture parameter estimation in SAR images

This paper deals with the validation of a previously developed texture model for SAR data as well as its associated parameter estimation algorithm. The mentioned model is named the Anisotropic Gaussian Kernel (AGK) model and allows the description of the possibly nonstationary and anisotropic behaviour of texture on heterogeneous areas of SAR images. The parameter estimation performance is evaluated over simulated data. We also investigate about the validity of our model over experimental data, by means of dissimilarity measures.
Lean Healthcare and Ontario Case Costing - An Examination of Strategic Change and Management Control Systems

In this paper we examine how two different strategic changes influence the Management Control Systems in six Ontario based hospitals. These changes are: 1. new funding regimes based on Ontario Case Costing and, 2. Lean Healthcare initiatives in Ontario Hospitals.The Ontario Case Costing (OCC) approach is based on the traditional MAS assumption that more accurate costs will lead to lower costs through better management decisions of some sort. In contrast, Lean Healthcare is premised on the assumption that the primary path to better performance is realized by individual employees, who serve as the leading actors in a daily process of waste removal and efficiency improvement.Based on the MA literature and on information about both the OCC and Lean Healthcare initiatives, we expect there to be significant frictions inside the financial management staff as well as between the Lean initiative and the financial management staff related to the OCC mandate. This study examines this set of interactions to learn how these issues impact the employees involved. In particular, the Ontario context allows us to examine the variety of responses to the interaction of Lean healthcare strategy and a traditional MAS such as OCC.We find that the MASs of hospitals in our sample are too loosely coupled to develop the frictions indicated by traditional MAS theory and propose modifications in application of the theory to accommodate this observation.
Erythromycin- and Chloramphenicol-Induced Ribosomal Assembly Defects Are Secondary Effects of Protein Synthesis Inhibition

ABSTRACT Several protein synthesis inhibitors are known to inhibit ribosome assembly. This may be a consequence of direct binding of the antibiotic to ribosome precursor particles, or it could result indirectly from loss of coordination in the production of ribosomal components due to the inhibition of protein synthesis. Here we demonstrate that erythromycin and chloramphenicol, inhibitors of the large ribosomal subunit, affect the assembly of both the large and small subunits. Expression of a small erythromycin resistance peptide acting in cis on mature ribosomes relieves the erythromycin-mediated assembly defect for both subunits. Erythromycin treatment of bacteria expressing a mixture of erythromycin-sensitive and -resistant ribosomes produced comparable effects on subunit assembly. These results argue in favor of the view that erythromycin and chloramphenicol affect the assembly of the large ribosomal subunit indirectly.
Origins of the Greenland shark (Somniosus microcephalus): Impacts of ice‐olation and introgression

Abstract Herein, we use genetic data from 277 sleeper sharks to perform coalescent‐based modeling to test the hypothesis of early Quaternary emergence of the Greenland shark (Somniosus microcephalus) from ancestral sleeper sharks in the Canadian Arctic‐Subarctic region. Our results show that morphologically cryptic somniosids S. microcephalus and Somniosus pacificus can be genetically distinguished using combined mitochondrial and nuclear DNA markers. Our data confirm the presence of genetically admixed individuals in the Canadian Arctic and sub‐Arctic, and temperate Eastern Atlantic regions, suggesting introgressive hybridization upon secondary contact following the initial species divergence. Conservative substitution rates fitted to an Isolation with Migration (IM) model indicate a likely species divergence time of 2.34 Ma, using the mitochondrial sequence DNA, which in conjunction with the geographic distribution of admixtures and Pacific signatures likely indicates speciation associated with processes other than the closing of the Isthmus of Panama. This time span coincides with further planetary cooling in the early Quaternary period followed by the onset of oscillating glacial‐interglacial cycles. We propose that the initial S. microcephalus–S. pacificus split, and subsequent hybridization events, were likely associated with the onset of Pleistocene glacial oscillations, whereby fluctuating sea levels constrained connectivity among Arctic oceanic basins, Arctic marginal seas, and the North Atlantic Ocean. Our data demonstrates support for the evolutionary consequences of oscillatory vicariance via transient oceanic isolation with subsequent secondary contact associated with fluctuating sea levels throughout the Quaternary period—which may serve as a model for the origins of Arctic marine fauna on a broad taxonomic scale.
Clinical relevance of telomerase polymorphism for breast cancer: A systematic review.

PURPOSE To perform a systematic review to explore the clinical relevance of hTERT polymorphisms for breast cancer (BC). METHODS Twenty-nine polymorphic regions were evaluated after comprehensive searching of 1236 articles, and selection of 9 publications (total of 12986 cases and 16758 controls). RESULTS About the influence of hTERT variants in BC risk, 3 studies showed that the variant rs2736098 was associated with increasing risk. The variants rs10069690 and rs2853676 were also described as risk factors for BC. Only one variant rs2736100 presented as risk factor for BC. MNS16A genotype influenced the risk of BC in an Iranian, but not in the Greek and American populations. The associations of 5 hTERT variants with expression of hormone receptors were also evaluated in some studies. One study showed that the variant rs10069690 was associated to the estrogen receptor (ER)-negative and triple negative subtype, but other authors did not find the same results. In addition, the association of rs273618 with ER-/progesterone receptor (PR)+ cases, and rs10069690, rs2735940, rs4246742 and rs2736100 with both negative receptors were described. After data reanalyses, we found that the variant rs2735940 and rs2736100 were associated with ER-/PR- cases among patients with BC. Also, the variant rs2736100 was associated with ER+/PR+ cases and the variant rs2736118 was associated to ER+/PR+ and ER-/PR+ cases. CONCLUSIONS The associations between hTERT variants and BC risk and outcomes could be useful since a polymorphism can be identified before the diagnosis, but the heterogeneity of data and analyses found in different studies lead to many controversies.
The Effects of Sertraline and Fluoxetine on Anxiety in the Elevated Plus-Maze Test

The aim of this study was to evaluate the acute and chronic effects of two SSRIs (sertraline and fluoxetine) on anxiety by the elevated plus-maze test. Diazepam increased the time spent in open arms significantly whereas the anxiogenic m-chlorophenylpiperazine (m-CPP) decreased the time significantly. Acute sertraline (10 mg x kg(-1)) and fluoxetine (20 mg x kg(-1)) treatment significantly decreased the time spent in open arms. Acute fluoxetine (20 mg x kg(-1)) treatment also decreased the total number of enclosed arm entries. Seven days sertraline treatment decreased the time spent in open arms, whereas 14 days fluoxetine treatment increased the time spent in open arms. These results show that acute administration of SSRIs may produce anxiogenic effects in the elevated plus-maze test.
The e V ects of the members of growth hormone family knockdown in zebra W sh development

Growth hormone (GH), prolactin (PRL), and somatolactin (SL) are members of GH/PRL superfamily. These hormones are involved in the regulation of an array of physiological processes, including growth, lactation, and osmoregulation. While recent evidence has shown the GH, PRL, and SL gene transcripts and protein products are expressed during early zebraWsh development, their functions at this time of embryogenesis remain unknown. In the current study, antisense morpholino oligonucleotide (MO) inhibition of gh, prl, and sl gene translation was used to examine the eVects of gene knockdown on hormone function in zebraWsh development. We observed that PRL, SL and SL MO treatment all aVected development. PRL MO-treated embryos showed defects in gas bladder inXation, reduced head and eye size, shorter body length and fewer melanophores than untreated controls, whereas SL and SL MO-treated embryos were only defective in gas bladder inXation, GH MO-inhibition of GH speciWc translation did not lead to any discernable morphological changes within 10 days post fertilization (dpf). The eVects of PRL knockdown were further veriWed using a second PRL morpholino antisense and by a rescue experiment with in vitro transcribed prl mRNA containing 5 nucleotide mismatch within the PRL–MO binding region. These results provide the Wrst evidence that members of the GH/PRL superfamily play a role in proper development of various structures including the head, eyes, melanophores and the gas bladder in zebraWsh. © 2006 Elsevier Inc. All rights reserved.