Miracle-dz/UniFAR-FTUs huggingface dataset:
2x2 STC with Full Rate and Full Diversity for Mobile WiMAX

The 2 × 2 MIMO profiles included in Mobile WiMAX specifications are Alamouti’s space-time code (STC) for transmit diversity and spatial multiplexing (SM). The former has full diversity and the latter has full rate, but neither of them has both of these desired features. An alternative 2×2 STC, which is both full rate and full diversity, is the Golden code. It is the best known 2×2 STC, but it has a high decoding complexity. Recently, the attention was turned to the decoder complexity, this issue was included in the STC design criteria, and different STCs were proposed. In this thesis, a full-rate full-diversity 2 × 2 STC design leading to substantially lower complexity of the optimum detector compared to the Golden code with only a slight performance loss. We provide the general optimized form of this STC and show that this scheme achieves the diversitymultiplexing frontier for square QAM signal constellations. Then, we present a variant of the proposed STC, which provides a further decrease in the detection complexity with a rate reduction of 25% and show that this provides an interesting trade-off between the Alamouti scheme and SM.
Strategy for 3D Reconstruction of Industrial Rubber Part

The motivation for this paper c omes from problems involved with the 3D surface reconstruction of the black components in rubber industry. In this paper, a stereo vision system made by two low-cost cameras, a multi-media projector is explained at first. In order to calibrate cameras, an algorithm based on quaternion attitude description is applied to simplify initial values achieving procedure and overcome the correlation problems of the least square estimation based on 2D planar pattern. A method combined with gray code and epipolar geometry is a dopted to deal with the matching problem without texture. The whole mathematical algorithms for 3D space coordinates are proposed based on the linear computation and nonlinear space intersection from stereo vision. The experimental results show s that the relative accuracy for 3D reconstruction could reach 1/10000. This indicated that the methods used in this paper were feasible for 3D reconstruction of textureless objects.
An amino-terminal c-myc domain required for neoplastic transformation activates transcription

The product of the c-myc proto-oncogene is a nuclear phosphoprotein whose normal cellular function has not yet been defined. c-Myc has a number of biochemical properties, however, that suggest that it may function as a potential regulator of gene transcription. Specifically, it is a nuclear DNA-binding protein with a short half-life, a high proline content, segments that are rich in glutamine and acidic residues, and a carboxyl-terminal oligomerization domain containing the leucine zipper and helix-loop-helix motifs that serve as oligomerization domains in known regulators of transcription, such as C/EBP, Jun, Fos, GCN4, MyoD, E12, and E47. In an effort to establish that c-Myc might regulate transcription in vivo, we sought to determine whether regions of the c-Myc protein could activate transcription in an in vitro system. We report here that fusion proteins in which segments of human c-Myc are linked to the DNA-binding domain of the yeast transcriptional activator GAL4 can activate transcription from a reporter gene linked to GAL4-binding sites. Three independent activation regions are located between amino acids 1 and 143, a region that has been shown to be required for neoplastic transformation of primary rat embryo cells in cooperation with a mutated ras gene. These results demonstrate that domains of the c-Myc protein can function to regulate transcription in a model system and suggest that alterations of Myc transcriptional regulatory function may lead to neoplastic transformation.
Experimental study of IP spoofing attack in 6LoWPAN network

6L0WPAN is a communication protocol for Internet of Things. 6LoWPAN is IPv6 protocol modified for low power and lossy personal area networks. 6LoWPAN inherits threats from its predecessors IPv4 and IPv6. IP spoofing is a known attack prevalent in IPv4 and IPv6 networks but there are new vulnerabilities which creates new paths, leading to the attack. This study performs the experimental study to check the feasibility of performing IP spoofing attack on 6LoWPAN Network. Intruder misuses 6LoWPAN control messages which results into wrong IPv6-MAC binding in router. Attack is also simulated in cooja simulator. Simulated results are analyzed for finding cost to the attacker in terms of energy and memory consumption.
SN 2012cg: EVIDENCE FOR INTERACTION BETWEEN A NORMAL SN Ia AND A NON-DEGENERATE BINARY COMPANION

We report evidence for excess blue light from the Type Ia supernova (Sn Ia) SN 2012cg at 15 and 16 days before maximum B-band brightness. The emission is consistent with predictions for the impact of the supernova on a non-degenerate binary companion. This is the first evidence for emission from a companion to a normal SN Ia. Sixteen days before maximum light, the B − V ? > color of SN 2012cg is 0.2 mag bluer than for other normal SN Ia. At later times, this supernova has a typical SN Ia light curve, with extinction-corrected M B = − 19.62 ± 0.02 ? > mag and Δ m 15 ( B ) = 0.86 ± 0.02 ? > . Our data set is extensive, with photometry in seven filters from five independent sources. Early spectra also show the effects of blue light, and high-velocity features are observed at early times. Near maximum, the spectra are normal with a silicon velocity vSi = −10,500 km s−1. Comparing the early data with models by Kasen favors a main-sequence companion of about six solar masses. It is possible that many other SN Ia have main-sequence companions that have eluded detection because the emission from the impact is fleeting and faint.
Mass Culture and Characterization of Tumor Cells From a Naturally Occurring Invertebrate Cancer Model: Applications for Human and Animal Disease and Environmental Health

On the northeastern coast of the United States and Canada, Mya arenaria, the soft shell clam, develops a diffuse, hemopoetic tumor (a fatal leukemia-like cancer) resulting from inactivation of p53-like family member proteins.These malignant cells provide a model for an unrelated set of human cancer cells that are also characterized by mortalin-based cytoplasmic sequestration of wild-type p53 tumor suppressor protein (mortalin is the mitochondrial Hsp70 protein). Here we describe methods for mass culture and long-term storage of tumor cells from this cancer. These are the first successful efforts at maintaining malignant cells from any marine invertebrate in vitro. Following passage (subculture), these cultures undergo transition from primary cultures to non-immortalized cell lines that continue to proliferate and do not re-differentiate the normal hemocyte phenotype. We also characterize normal clam hemocytes and the pathology of cancerous clam hemocytes in vitro and in vivo using light and electron microscopy, cyto- and immunocytochemistry, molecular biology, and a phagocytosis assay. Our protocols provide biomedical and environmental researchers with ready access to this naturally occurring cancer model. We discuss the clam cancer model regarding (a) human health and disease; (b) animal health, disease, and aquaculture; (c) environmental health monitoring; and (d) future research directions.
MMPI-2 Clinical Scale 6 (Paranoia) and Restructured Clinical Scale 6 (Ideas of Persecution) in Child Custody Litigants

The MMPI-2 is the most frequently used psychological test with parents undergoing child custody evaluations (CCE’s). Studies of parents who completed the MMPI-2 in the CCE context have consistently found that, on average, parents portray a very favorable image of themselves as both virtuous and psychologically well-adjusted. Also, on average, Clinical Scale 6 (Paranoia) and its counterpart on the Restructured Clinical Scales, RC6, “Ideas of Persecution”, have been the most frequently elevated of the clinical scales on the MMPI-2 in samples of child custody litigants, albeit, the reported scores on these scales were well within the norm. This paper examines the significance of clinically elevated scores on Scale 6 (and RC6) in parents undergoing CCE’s, with consideration of both contextual and psychometric features. Based on these considerations, this writer suggests that custody evaluators may encounter the paradox that some parents whose clinical profile suggests mistrust and suspiciousness in interpersonal relations may actually trust enough to report their perceptions in a candid and forthcoming manner. Some of these parents may not be mistrustful in general and might not be inclined to model or influence their children toward the development of mistrust. In contrast, other parents may respond to the test in a more defensive and deceptive manner resulting in a “normal” clinical profile, which may be specific to the evaluation context, but may also reflect moral righteousness and a more insidious tactic. The custody evaluator is advised to use caution when interpreting clinically elevated scores on the MMPI-2.
Mediterranean Moisture Source for an Early-Holocene Humid Period in the Northern Red Sea

Paleosalinity and terrigenous sediment input changes reconstructed on two sediment cores from the northernmost Red Sea were used to infer hydrological changes at the southern margin of the Mediterranean climate zone during the Holocene. Between approximately 9.25 and 7.25 thousand years ago, about 3‰ reduced surface water salinities and enhanced fluvial sediment input suggest substantially higher rainfall and freshwater runoff, which thereafter decreased to modern values. The northern Red Sea humid interval is best explained by enhancement and southward extension of rainfall from Mediterranean sources, possibly involving strengthened early-Holocene Arctic Oscillation patterns and a regional monsoon-type circulation induced by increased land-sea temperature contrasts. We conclude that Afro-Asian monsoonal rains did not cross the subtropical desert zone during the early to mid-Holocene.
Attachement parental et addiction aux substances psychoactives - Étude transversale comparative au centre hospitalier spécialisé de Zébé (Togo)

ResumeLes raisons de l’augmentation des conduites addictives observees chez les jeunes adultes ne sont pas toujours tres bien definies. Cette etude avait pour objectif de determiner d’une part le lien entre les types d’attachement parental et l’addiction aux substances psychoactives et, d’autre part, le type d’attachement et la substance psychoactive consommee. Il s’est agi d’une etude comparative transversale portant sur deux echantillons, un groupe de 112 sujets presentant une addiction et un groupe temoin de non-usagers. Le groupe des sujets presentant une addiction etait composes de tous les sujets presentant une addiction, selon les criteres diagnostiques de la CIM-10, et suivis a l’hopital de juin en decembre 2010. Les sujets non-usagers (primaires ou secondaires) ont ete selectionnes selon la technique du tout-venant durant la meme periode, parmi les accompagnants de malades et visiteurs de l’hopital. Le type d’attachement parental dans les deux groupes a ete evalue par le questionnaire de Bartholomew et Horowitz (1991). Les sujets non-usagers ont un attachement secure dans 64,28% contre 96,43% de sujets presentant une addiction ayant un type d’attachement insecure. L’attachement insecure evitant est associe a l’addiction a l’alcool, au tabac et au cannabis, l’attachement insecure craintif a l’addiction a l’alcool et au tabac, l’attachement insecure preoccupe a l’addiction de la plupart des substances psychoactives. Cette etude confirme l’influence determinante dans le choix de la conduite addictive, de l’histoire evenementielle du sujet dans son enfance, et en particulier de la qualite des premieres interactions de l’enfant avec son environnement.
[MicroRNA differential expression profile during differentiation of embryonic stem cells towards hepatocytes induced by sodium butyrate].

OBJECTIVE To explore the expression profile of microRNAs during the course of embryonic stem cells differentiation towards hepatocytes induced by sodium butyrate. METHODS Total RNA was extracted from embryonic stem cells on day 0, 6, and 9 during cell differentiation, and microRNA was isolated from the total RNA. Microarray analysis of microRNA expression was performed to detect the different expression levels of microRNA among the indicated time points (day 0, 6, and 9). RESULTS Compared with the microRNA expression level on day 0 of cell differentiation, 17 different microRNAs exhibited higher expressions both on day 6 and day 9. Twenty-two and 27 microRNA demonstrated lower expressions on day 6 and day 9, respectively. Further analysis revealed that 15 microRNA among the above microRNAs with significant differential expression may keep close interation with histone deacetylase. CONCLUSION During the course of embryonic stem cells differentiation towards hepatocytes induced by sodium butyrate, histone deacetylase and its relevant microRNAs may play important roles in cell differentiation.
Hyperuricemia and incident hypertension: A systematic review and meta‐analysis

A novel rodent model and a recent randomized trial of hyperuricemic adolescents with hypertension suggest a pathogenetic role of uric acid in hypertension, but it remains unknown whether these findings would be applicable to adult populations where the larger disease burden exists. We conducted a systematic review and meta‐analysis to determine if hyperuricemia was associated with incident hypertension, particularly in various demographic subgroups.
Contribution of obesity to hepatitis C-related fibrosis progression

OBJECTIVE:Hepatitis C virus (HCV) disease progression is variable. Identification of factors predictive of rapid progression is an important goal for improving patient management. The aim of this study was to evaluate the predictive role of several variables, including some that are etiologically related to the nonalcoholic steatohepatitis (NASH) syndrome such us obesity, in fibrosis progression in both patients with elevated and normal transaminase levels.METHODS:A total of 114 chronic HCV-infected (HCV-RNA positive) patients were recruited prospectively between 2000 and 2001. All patients had at least one liver biopsy. The annual change in fibrosis stage (fibrosis progression rate) was assessed from the time of presumed infection (fibrosis = 0) among those who had only one biopsy (n = 97) or between two biopsies if these were available (n = 17). Based on published data, we arbitrarily defined a patient as a rapid progressor when the fibrosis progression rate was >0.2 U/yr. Potential predictors of rapid progression were: age at infection and biopsy, sex, significant alcohol intake (>50 g/day), risk factor of HCV acquisition (based on answers to a questionnaire), obesity (based on body mass index [BMI]), autoantibodies, iron overload (ferritin, transferrin saturation), diabetes, hyperlipidemia, anti-HBcore IgG, genotype, and viral load.RESULTS:The median fibrosis progression rate was 0.05 U/yr (range 0–1.58 yr). In all, 22 patients (19%) were rapid progressors. Variables associated with progression by multivariate analysis included: advanced age at infection (p = 0.0001), BMI ≥25 (p = 0.01), and ALT >1.5 times upper limit of normal (p = 0.01). Among patients with ALT >1.5 times upper limit of normal, these variables were advanced age at infection, BMI ≥25, diabetes and transferrin saturation >45. Among those with normal ALT levels, only BMI ≥30 was predictive of progression.CONCLUSIONS:Obesity, advanced age at infection, and elevated ALT levels predict rapid disease progression, suggesting that measures aimed at weight reduction may play a significant role in hepatitis C management. The natural history of hepatitis C is independent of the presence of autoimmunity markers.
Novel Mode of Action of Angiotensin I Converting Enzyme Inhibitors

Angiotensin I converting enzyme (kininase II; ACE) inhibitors are important therapeutic agents widely used for treatment in cardiovascular and renal diseases. They inhibit angiotensin II release and bradykinin inactivation; these actions do not explain completely the clinical benefits. We found that enalaprilat and other ACE inhibitors in nanomolar concentrations activate human bradykinin B1 receptors directly in the absence of ACE and the B1 agonist des-Arg10-Lys1-bradykinin. These inhibitors activate at the Zn2+-binding consensus sequence HEXXH (195–199) in B1, which is present also in ACE but not in the B2 receptor. Activation elevates [Ca2+] i and releases NO from endothelial or transfected cells expressing the B1 receptor but is blocked by Ca-EDTA, a B1 receptor antagonist, the synthetic undecapeptide sequence (192–202) of B1, and the mutagenesis of His195 to Ala195. Except for the B1 antagonist, these agents and manipulations did not block activation by a peptide ligand. Thus, Zn2+ is essential for B1 receptor activation by ACE inhibitors at the zinc-binding consensus sequence. Ischemia or cytokines induce abundant B1 receptor expression. B1 receptor activation by ACE inhibitors, a novel mode of action reported here first, can contribute to their therapeutic effects by releasing NO in the heart and to some side effects.
Future internet architecture and testbeds

With the tremendous advances in the field of information and communications technology (ICT), and the emergence of new applications, such as 4K/8K, AR/VR, Internet of Things, and Industrial Internet and so on, the traditional Internet has faced severe challenges on scalability, flexibility, controllability, mobility and security and so on. In order to cope with these challenges, numerous promising future Internet architectures and techniques, such as software-defined networking (SDN), information-centric networking (ICN), and network virtualization (NV), have emerged over the last few years and been attracted a lot of attention.
A RAPID algorithm for sequence database comparisons: application to the identification of vector contamination in the EMBL databases

MOTIVATION Word-matching algorithms such as BLAST are routinely used for sequence comparison. These algorithms typically use areas of matching words to seed alignments which are then used to assess the degree of sequence similarity. In this paper, we show that by formally separating the word-matching and sequence-alignment process, and using information about word frequencies to generate alignments and similarity scores, we can create a new sequence-comparison algorithm which is both fast and sensitive. The formal split between word searching and alignment allows users to select an appropriate alignment method without affecting the underlying similarity search. The algorithm has been used to develop software for identifying entries in DNA sequence databases which are contaminated with vector sequence. RESULTS We present three algorithms, RAPID, PHAT and SPLAT, which together allow vector contaminations to be found and assessed extremely rapidly. RAPID is a word search algorithm which uses probabilities to modify the significance attached to different words; PHAT and SPLAT are alignment algorithms. An initial implementation has been shown to be approximately an order of magnitude faster than BLAST. The formal split between word searching and alignment not only offers considerable gains in performance, but also allows alignment generation to be viewed as a user interface problem, allowing the most useful output method to be selected without affecting the underlying similarity search. Receiver Operator Characteristic (ROC) analysis of an artificial test set allows the optimal score threshold for identifying vector contamination to be determined. ROC curves were also used to determine the optimum word size (nine) for finding vector contamination. An analysis of the entire expressed sequence tag (EST) subset of EMBL found a contamination rate of 0.27%. A more detailed analysis of the 50 000 ESTs in est10.dat (an EST subset of EMBL) finds an error rate of 0.86%, principally due to two large-scale projects. AVAILABILITY A Web page for the software exists at http://bioinf.man.ac.uk/rapid, or it can be downloaded from ftp://ftp.bioinf.man.ac.uk/RAPID CONTACT: crispin@cs.man.ac.uk
Prevalence and correlates of high body mass index in rural Appalachian children aged 6-11 years.

INTRODUCTION In rural regions of the United States of America, estimates of pediatric obesity often exceed national averages. This problem may be particularly pronounced in Appalachian regions, where significant health and economic disparities abound. This study presents the findings of a body mass index (BMI) screening program for 6-11 year old children living in a rural Appalachian community. County-wide estimates of high BMI (>or=85th percentile) were obtained to understand the health status and needs of our pediatric community and to compare obesity prevalence rates with national averages. An additional aim was to identify subpopulations of children who may warrant clinical intervention due to demographic and behavioral risks factors of high BMI. METHODS A school-based BMI screening was conducted of 6-11 year old children in southeastern Ohio. Investigators collected 3 sets of height and weight measurements from approximately 2000 elementary school students between 2006 and 2007. Caregivers for a subset of this population also completed a health behaviors questionnaire. RESULTS Thirty-eight percent of children had high BMI, with 17% at risk for overweight and 20.9% overweight. Boys were 23% more likely than girls to be overweight (chi(2)(1) = 95% CI = 1.08, 1.40) and 11% more likely to become overweight with each year of age (OR = 1.11, 95% CI = 1.07, 1.15). Overweight children were more likely to view television, eat meals at school, and live with a caregiver who smokes. CONCLUSIONS Consistent with expectations, prevalence of high BMI in this sample of rural Appalachian children exceeds national averages. Prevalence of overweight varied by age and sex; boys are particularly vulnerable to developing obesity, especially as they age. Preliminary survey data suggest that eating breakfast at home and at school and increased hours of television viewing may be associated with higher BMI, especially in younger boys.
Creative foraging: An experimental paradigm for studying exploration and discovery

Creative exploration is central to science, art and cognitive development. However, research on creative exploration is limited by a lack of high-resolution automated paradigms. To address this, we present such an automated paradigm, the creative foraging game, in which people search for novel and valuable solutions in a large and well-defined space made of all possible shapes made of ten connected squares. Players discovered shape categories such as digits, letters, and airplanes as well as more abstract categories. They exploited each category, then dropped it to explore once again, and so on. Aligned with a prediction of optimal foraging theory (OFT), during exploration phases, people moved along meandering paths that are about three times longer than the shortest paths between shapes; when exploiting a category of related shapes, they moved along the shortest paths. The moment of discovery of a new category was usually done at a non-prototypical and ambiguous shape, which can serve as an experimental proxy for creative leaps. People showed individual differences in their search patterns, along a continuum between two strategies: a mercurial quick-to-discover/quick-to-drop strategy and a thorough slow-to-discover/slow-to-drop strategy. Contrary to optimal foraging theory, players leave exploitation to explore again far before categories are depleted. This paradigm opens the way for automated high-resolution study of creative exploration.