Miracle-dz/UniFAR-FTUs huggingface dataset:
Nationwide Survey of Hemophagocytic Lymphohistiocytosis in Japan

Hemophagocytic lymphohistiocytosis (HLH), a disorder of the mononuclear phagocyte system, can be classified into two distinct forms: primary HLH (FHL) and secondary HLH. To clarify the epidemiology and clinical outcome for each HLH subtype, we conducted a nationwide survey of HLH in Japan. Since 799 patients were diagnosed in 292 institutions of Japan between 2001 and 2005, the annual incidence of HLH was estimated as 1 in 800,000 per year. Among them, 567 cases were actually analyzed in this study. The most frequent subtype was Epstein-Barr virus (EBV)-associated HLH, followed by other infection- or lymphoma-associated HLH. Age distribution showed a peak of autoimmune disease- and infection-associated HLH in children, while FHL and lymphoma-associated HLH occurred almost exclusively in infants and the elderly, respectively. The 5-year overall survival rate exceeded 80% for patients with EBV- or other infection-associated HLH, was intermediate for those with FHL or B-cell lymphoma-associated HLH, and poor for those with T/NK cell lymphoma-associated HLH (<15%). Although this nationwide survey establishes the heterogeneous characteristics of HLH, the results should be useful in planning prospective studies to identify the most effective therapy for each HLH subtype.
Development of a nutritious low viscosity weaning mix using natural ingredients and microbial amylases

A nutritious weaning food was developed using natural ingredients; namely, staple cereals and pulses, groundnut, Spirulina and gooseberry. The nutritive value of the developed weaning mix was found to be better than a commercial mix. The viscosity of the mixes was reduced by the addition of bacterial and fungal amylases. Addition of amylases at a concentration of 0.1-0.4% drastically reduced the viscosity in all the formulated mixes. The maximum viscosity reduction effect was evident at 0.2% for bacterial amylase and at 0.4% for fungal amylases.
The Canadian Early Arthritis Cohort (CATCH): Patients with New-onset Synovitis Meeting the 2010 ACR/EULAR Classification Criteria But Not the 1987 ACR Classification Criteria Present with Less Severe Disease Activity

Objective. Our objective was to describe characteristics of Canadian patients with early arthritis and examine differences between those fulfilling 1987 and 2010 rheumatoid arthritis (RA) classification criteria. Methods. The Canadian Early Arthritis Cohort (CATCH) is a national, multicenter, observational, prospective cohort of patients with early inflammatory arthritis, receiving usual care, recruited since 2007. Inclusion criteria include age > 16 years; symptom duration 6–52 weeks; swelling of ≥ 2 joints or ≥ 1 metacarpophalangeal/proximal interphalangeal joint; and 1 of rheumatoid factor ≥ 20 IU, positive anticitrullinated protein antibodies (ACPA), morning stiffness ≥ 45 min, response to nonsteroidal antiinflammatory drug, or positive metatarsophalangeal joint squeeze test. Data from patients enrolled to March 15, 2011, were analyzed. Results. In total, 1450 patients met the eligibility criteria (1187 were followed). At baseline, mean age was 53 ± 15 years, symptom duration was 6.1 ± 3.2 months, Disease Activity Score (DAS28) was 4.9 ± 1.6, Health Assessment Questionnaire-Disability Index was 1.0 ± 0.7. Forty-one percent (n = 450) of patients had moderate (3.2 < DAS28 ≤ 5.1) and 46% (n = 505) had high (DAS28 > 5.1) disease activity; 28% of those with baseline radiographs (n = 250/908) had radiographic evidence of erosions. ACPA status was available for 70% (n = 831) of patients; 55% (n = 453) tested positive. Sixty percent (n = 718) of patients were treated with methotrexate (MTX) initially. Of 612 patients without erosions, 63% and 83% fulfilled 1987 and 2010 RA classification criteria, respectively. Seventy-three percent (n = 166) of those who did not fulfill 1987 criteria were newly identified by the 2010 criteria. These patients had less severe disease and more were MTX-naive compared to those satisfying the 1987 criteria. Forty-seven percent of all patients achieved remission at 1 year. Conclusion. Patients with early RA present with moderate high disease activity; < 50% achieve remission at 1 year, despite MTX treatment in the majority. The 2010 RA classification criteria identify more patients with RA who would previously have been designated as having undifferentiated disease. However, these patients have lower disease activity at the time of identification.
Phylogeny and Power in the IS Domain: A Response to Benbasat and Zmud's Call for Returning to the IT Artifact

We question a call by Benbasat and Zmud (2003) to narrow the focus of information systems research to a set of core properties. We first discuss three limitations of their argument and then offer two alternative viewpoints for analyzing the state of our profession. One viewpoint casts the arguments of Benbasat and Zmud in terms of power in the domain of scholarship. The second viewpoint, based on colonial systems, sees fresh perspectives, discipline newcomers, boundary spanners, and topical outliers as the likely source of the field’s creativity, vitality, and long-term survival. We conclude that the discipline is best served by focusing on supporting diverse and novel research. We proffer neither an alternative research agenda nor a research-appropriate evaluation mechanism since we demonstrate that such restrictive policies hinder both our relevance ∗ Detmar Straub was the accepting senior editor for this paper. IS RESEARCH PERSPECTIVES ARTICLE Ives et al. /Phylogeny and Power in IS Journal of the Association for Information Systems Vol. 5 No. 3, pp. 108-124/March 2004 109 and potential survival. We suggest some administrative changes for the IS discipline intended to encourage and nurture creativity without sacrificing academic rigor.
Entwurf robuster modellbasierter Fehlerisolationsfilter

Die vorliegende Arbeit behandelt den Entwurf robuster modellbasierter Fehlerisolationsfilter fur lineare zeitinvariante Systeme. Die Verfahren erlauben eine zuverlassige Lokalisierung von Fehlern auf Basis eines quantitativen Systemmodells. Zunachst wird die Dualitat des Fehlerisolationsproblems zu Methoden des Entkopplungsreglerentwurfes herausgearbeitet. Auf dieser Grundlage werden Methoden zum Entwurf von Fehlerisolationsbeobachtern prasentiert. Die Robustheit der Beobachter sowohl hinsichtlich exogener Storungen als auch bezuglich unsicherer Systemparameter wird dabei unter Ruckgriff auf lineare Matrixungleichungen optimiert. Schlieslich werden Fehlerisolationsfilter allgemeinerer Struktur betrachtet, die gegenuber den beobachterbasierten Methoden einen vereinheitlichenden Entwurf liefern. Dieser erfolgt optimierungsbasiert und erlaubt eine einfache Auslegung, bei der lediglich intuitive Parameter einzustellen sind.
Effects of m-Tyrosine on Growth and Sporulation of Bacillus Species

Aronson, John N. (Arizona State University, Tempe), and Gerald R. Wermus. Effects of m-tyrosine on growth and sporulation of Bacillus species. J. Bacteriol. 90:38–46. 1965. —The aromatic amino acid analogue, dl-β-(3-hydroxyphenyl)alanine (m-tyrosine), reduced sporulation of a strain of Bacillus subtilis to less than 5% of that of control cultures in a glucose-salts minimal medium. The mass-doubling time increased twofold, but maximal growth equivalent to that of control cultures was eventually attained. A decreased growth rate could be maintained in the presence of the analogue for more than 10 doublings, despite incorporation of m-tyrosine-2-C14 in place of some of the protein phenylalanine. The organism proliferated to chain lengths of 10 to 15 cells. These cells persisted for many hours after maximal growth had been reached, in contrast to normal cultures which had begun to autolyze and sporulate. The response to m-tyrosine of strains of B. cereus, B. thuringiensis, and B. megaterium was like that of B. subtilis. In addition, B. thuringiensis and B. cereus converted m-tyrosine to dihydroxyphenylalanine, which was further oxidized to a melaninlike substance. Growth of a strain of B. stearothermophilus was not slowed by m-tyrosine, but a strain of Escherichia coli grew at a reduced rate.
A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho*

Small GTP-binding proteins of the Rho family play a critical role in signal transduction. However, there is still very limited information on how they are activated by cell surface receptors. Here, we used a consensus sequence for Dbl domains of Rho guanine nucleotide exchange factors (GEFs) to search DNA data bases, and identified a novel human GEF for Rho-related GTPases harboring structural features indicative of its possible regulatory mechanism(s). This protein contained a tandem DH/PH domain closely related to those of Rho-specific GEFs, a PDZ domain, a proline-rich domain, and an area of homology to Lsc, p115-RhoGEF, and a Drosophila RhoGEF that was termed Lsc-homology (LH) domain. This novel molecule, designated PDZ-RhoGEF, activated biological and biochemical pathways specific for Rho, and activation of these pathways required an intact DH and PH domain. However, the PDZ domain was dispensable for these functions, and mutants lacking the LH domain were more active, suggesting a negative regulatory role for the LH domain. A search for additional molecules exhibiting an LH domain revealed a limited homology with the catalytic region of a newly identified GTPase-activating protein for heterotrimeric G proteins, RGS14. This prompted us to investigate whether PDZ-RhoGEF could interact with representative members of each G protein family. We found that PDZ-RhoGEF was able to form, in vivo, stable complexes with two members of the Gα12 family, Gα12 and Gα13, and that this interaction was mediated by the LH domain. Furthermore, we obtained evidence to suggest that PDZ-RhoGEF mediates the activation of Rho by Gα12 and Gα13. Together, these findings suggest the existence of a novel mechanism whereby the large family of cell surface receptors that transmit signals through heterotrimeric G proteins activate Rho-dependent pathways: by stimulating the activity of members of the Gα12 family which, in turn, activate an exchange factor acting on Rho.
Can TCP and Locator / ID Separation get along ?

Aiming at solving the scalability problem that the current Internet is facing, the separation of the IP namespace into two different namespaces (the Locator and the Identifier namespaces) is one of the most promising paradigms. However, the impact of this new paradigm on the Internet traffic is yet to be assessed. In this extended abstract, we present a preliminary analysis of TCP performance in the context of Locator/ID separation.
Depot neuroleptic therapy: an underutilized treatment option.

BACKGROUND Depot neuroleptics are effective as long-term maintenance therapy in chronic schizophrenia and are widely used in Europe. In the United States, however, physicians have been reluctant to use them. They assume that depot neuroleptics present an increased risk of major side effects, that patients do not accept or tolerate them as well as oral agents, and that prescribing depot neuroleptics increases the possibility of medicolegal problems. METHOD We analyzed the published data on neuroleptic malignant syndrome, tardive dyskinesia, extrapyramidal symptoms, perceptions of depot therapy, and medicolegal concerns. Whenever possible, we used the Mantel-Haenszel test to compare the outcome of oral versus depot neuroleptic medication treatment. RESULTS Depot neuroleptics are not associated with an increase in any of the negative outcomes assessed. CONCLUSION Depot neuroleptics represent a valuable treatment option for many patients and merit wider use.
Prevalencija progresivnih parodontnih bolesti zagrebačkog stanovništva

Epidemioloπka ispitivanja parodontnih bolesti pokazuju da je potrebno ispitati ËestoÊu posebnih oblika progresivnih parodontnih bolesti, juvenilnog i rapidno progresivnog parodontitisa. Te bolesti poËinju u mladenaËkoj dobi pa zato zahtijevaju rano prepoznavanje i prikladan tretman. Na uzorku od 1202 ispitanika populacije grada Zagreba, prihvatljivom za ovo istraæivanje, ispitivali smo s pomoÊu CPITN-a ËestoÊu juvenilnog i rapidno progresivnog parodontitisa, te usporedili odnos udjela progresivnih oblika parodontne destrukcije prema drugim vrstama parodontnih bolesti. Ispitanici su bili πkolska djeca, radnici i sluæbenici svrstani u dobne skupine: 15-19, 20-24, 25-29, 30-34, 35-44 i > 55 godina. Za procjenu stanja parodonta primijenili smo CPITN koji Ëini srednji broj sekstanata ispitanika u kojih se javlja krvarenje iz gingivnoga sulkusa, zubni kamenac, te pliÊi ili dublji parodontni dæepovi. Dodatni kriteriji za procjenu tih oblika parodontitisa u mlaoj dobi bili su: jaËe izraæeni upalni simptomi na gingivi, aktivni i dublji parodontni dæepovi, te klimavost zuba. StatistiËkom obradom podataka, primjenom programa STATJOB-a dobiveni su rezultati koji pokazuju da prevalencija progresivnih parodontitisa na podruËju grada Zagreba iznosi 4,1% (juvenilnog 0,6% i rapidnog 3,5%). ËestoÊa gingivitisa kao poËetnog oblika parodontne bolesti mnogo je veÊa i iznosi do 82% u mlaoj dobi, a ËestoÊa parodontne bolesti u odraslih takoer je visoka i iznosi 80%. Ispitali smo i ËestoÊu pojedinih stupnjeva parodontne destrukcije. Tako je postotak osoba s dubokim parodontnim dæepovima u skupini s juvenilnim i rapidno progresivnim parodontitisom bio 87,7%, a u skupini s adultnim parodontitisom 9,5 %, πto upozorava na teæi oblik parodontne destrukcije u skupini s juvenilnim i rapidno progresivnim parodontitisom. Primjena CPITN-a pokazala se je orijentacijskom metodom kojom smo dobili uvid u prevalenciju ispitivanih oblika parodontne destrukcije te upotrebe tretmana. Na taj smo naËin izdvojili iz populacije pojedinaËne sluËajeva progresivnih parodontitisa koji traæe daljnje kliniËke pretrage i terapiju. KljuËne rijeËi: prevalencija, juvenilni parodontitis, rapidno progresivni parodontitis. Marija IviÊ-Kardum
Assessment of Patient Selection Criteria for Treatment of the Infected Hip Arthroplasty

In a group of 37 infected hip arthroplasties (36 patients) treated consecutively between January 1997 and October 1999, the feasibility of published patient selection criteria for direct exchange arthroplasty was tested. These criteria include the requirement of a healthy patient with good soft tissues, minimal femoral bone loss, and an organism identified preoperatively as an antibiotic sensitive gram-positive organism. After assignment of the selection criteria, only four patients (four hips) (11%) were deemed potential candidates for a direct exchange procedure. Infected arthroplasties excluded from a primary exchange included 14 patients (15 hips) with gram-negative or methicillin-resistant gram-positive organisms obtained from preoperative joint aspirations, 10 patients (10 hips) with moderate or severe femoral bone loss, four patients (four hips) who required a proximal femoral osteotomy for component removal, two patients (two hips) with poor health status, and two patients (two hips) with poor soft tissues. Because of the increasing emergence of antibiotic-resistant bacteria and an increased prevalence of revision arthroplasties with associated bone loss, the feasibility of published selection criteria for direct exchange are limited. A philosophy of delayed reconstruction for the treatment of the infected hip arthroplasty seems most appropriate in the current era of patient treatment.
STUDIES ON THE SPECIFICITY OF INTERFERON.

SUMMARY: The antiviral effects of chick and mouse interferons on chick and mouse cells were studied. In both systems a small amount of antiviral activity was found in the heterologous assays which varied from approximately 1 to 10 % of the homologous antiviral effect. A difference in the uptake of interferon by homologous and heterologous cells was observed which only partly explained the relative species specificity of the antiviral action of the two interferons. Destruction of interferon by supernatants from homologous or heterologous cultures could not be shown. The slopes of the dose response curves of mouse or chick interferon seemed to be significantly different and were independent of the two cell strains employed.
The World Health Organization Disability Assessment Schedule 2.0 can predict the institutionalization of patients with stroke.

BACKGROUND The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) is a well-known questionnaire used to evaluate disability. We can not only evaluate disability but also obtain additional information by using the standardized WHODAS 2.0 scores. AIM To predict the institutionalization of the patients with stroke by using the standardized WHODAS 2.0 scores. DESIGN Observational study. SETTING The data of 10,255 patients with stroke were acquired from the Data Bank of Persons with Disabilities (TDPD) in Taiwan. POPULATION Patients with either ischemic or hemorrhagic stroke during chronic stage. METHODS For the patients with stroke, we used a χ2 analysis for the categorical variables, and an independent Student's t test to compare the standardized WHODAS 2.0 scores in the six domains between different groups. We also generated a receiver operating characteristic curve using the standardized WHODAS 2.0 scores, and applied Youden Index to calculating the optimal cut-off point on the ROC curve. Then, we used a binary logistic regression analysis to determine risk factors for the institutionalization. RESULTS All WHODAS 2.0 domains had higher scores in the institution group than in the community group. The ROC curve used to predict the institutionalization of patients with stroke revealed that all WHODAS 2.0 domains were statistically significant. The cognition, and mobility domains and the sum of WHODAS 2.0 scores were more accurate for predicting the risk of institutionalization in a long-term care facility. In a logistic regression analysis, standardized WHODAS 2.0 scores ≥69, residence in an urban area, and severity of impairment were factors for predicting the institutionalization of the patients with stroke. CONCLUSIONS WHODAS 2.0 scores, urbanization level, and severity of impairment were positive factors for the institutionalization of patients with stroke in long-term care facilities, whereas the female sex and an age of ≥85 years were negative factors. The cognition and mobility domains and standardized WHODAS 2.0 scores were more accurate for predicting the institutionalization of patients with stroke. CLINICAL REHABILITATION IMPACT Proper analysis of the functioning status and risk factors, as well as prediction of discharge destination for the patients with stroke can help the healthcare system reduce unnecessary expenditures and make the allocation of social resources more efficient.
EFFECTS OF NICKEL AND ZINC ON BIOCHEMICAL PARAMETERS IN PLANTS-A REVIEW

The focus of the review is on the specific aspects of Ni and Zn effects on growth morphology, Biochemical activity/responses, mineral nutrition and enzyme activity of plants. The quantity of Ni required for normal growth and development of plant is very low. Ni has been identified as a component of various enzymes in plants, various other biochemical, physiological and growth responses. The concentrations of Ni and Zn in the environment are currently increasing due mainly of human activities. Zn and Ni are essential elements for several biochemical processes in plants. At high concentration in soil, can cause severe damage to physiological and biochemical activities of plants. The higher concentration of Ni is associated with soils, plants chlorosis and inhibits, root and shoot growth. Excess of Ni inhibits a large number of enzyme and including photosynthesis; pigments synthesis.
Interaction of 4,4′-Dithiodipyridine with Cys458 Triggers Disassembly of GroEL*

Chaperonin GroEL, consisting of two seven-subunit rings stacked back-to-back, is disassembled by interaction of 4,4′-dithiodipyridine (DTP) with Cys458 located close to the intersubunit contacts within and between the rings. The thiol group of Cys458 is inaccessible to the probe being buried into the pocket locked by segment Asn475–Asn487. Flexibility of this segment is proposed to induce the “open” state of the pocket and accommodate the bulky probe inside so that the consequential irreversible shifts in the pocket constituents disassemble GroEL. This scheme is supported by the finding that DTP-induced disassembly of GroEL is facilitated by ATP, which specifically stimulates a local shift of the segment Asn475–Asn487 into solution.
Mapping of Functional Domains in Eukaryotic Protein Synthesis Initiation Factor 4G (eIF4G) with Picornaviral Proteases

Cap-dependent binding of mRNA to the 40 S ribosomal subunit during translational initiation requires the association of eukaryotic initiation factor 4G (eIF4G; formerly eIF-4γ and p220) with other initiation factors, notably eIF4E, eIF4A, and eIF3. Infection of cells by picornaviruses results in proteolytic cleavage of eIF4G and generation of a cap-independent translational state. Rhinovirus 2A protease and foot-and-mouth-disease virus L protease were used to analyze the association of eIF4G with eIF4A, eIF4E, and eIF3. Both proteases bisect eIF4G into N- and C-terminal fragments termed cpN and cpC·. cpN was shown to contain the eIF4E-binding site, as judged by retention on m7GTP-Sepharose, whereas cpC· was bound to eIF3 and eIF4A, based on ultracentrifugal co-sedimentation. Further proteolysis of cpN by L protease produced an 18-kDa polypeptide termed cpN2 which retained eIF4E binding activity and corresponded to amino acid residues 319-479 of rabbit eIF4G. Further proteolysis of cpC· yielded several smaller fragments. cpC2 (∼887-1402) contained the eIF4A binding site, whereas cpC3 (∼480-886) contained the eIF3 binding site. These results suggest that cleavage by picornaviral proteases at residues 479-486 separates eIF4G into two domains, one required for recruiting capped mRNAs and one for attaching mRNA to the ribosome and directing helicase activity. Only the latter would appear to be necessary for internal initiation of picornaviral RNAs.
Design and realization of multi-channel test Software based on Vector Network Analyzer

In order to verify the test results consistency, the design and realization of multi-channel test Software based on Vector Network Analyzer is introduced in this paper. The platform of software development is LabWindows/CVI. This software realizes multi-channel test by using switching network. It not only completes normal test of DUT (device under test), but also verifies the test results consistency, so the test results are more reliable. Meanwhile, it realizes that mass test data is quickly stored, compared and displayed through graphs. The database management system is MySQL database, which quickly processes data, and has large capacity. The Software is strong practicability and easy-to-use.