Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization and screening of thermophilic strains forphenol degradation

This research is about characterization, screening, and enzymatic assay for potential phenol degrader. The objectives of this research are to characterize the thermophilic strains, to screen the thermophilic strains towards utilization of phenol at various concentration, and to detect the catechol 2,3 dioxygenase activities. Three thermophilic strains that isolated from Oil Palm Empty Fruit Bunch (OPEFB), namely NAedEFBs-Cr1, NAdEFBus-Cr1. and RdEFBs-Cr1 were characterized by their colony morphology and cellular morphology. All these three strains are cocci, aerobic bacteria, have no endospore, are not able to reduce sulphur, and cream in colour. For NAedEFBs-Crl and RdEFBs-Crl, both are Gram-positive and not motile bacterium whereas NAdEFBus-Crl is a Gram-negative and motile bacterium. All the three strains were tested for their growth curve at 40Â°C, 50 Â°C, and 60Â°C for 24 hours incubation at 200 rpm. The growth temperature is at 40 Â°e. Among the three strains, NAdEFBus-Cr1 is the most tolerance toward phenol where it can grow dense in phenol-containing Ramsay Agar at concentrations of 0.5 mM, 1.0 mM, and 1.5 mM. This strain also shows the highest growth of cells in phenol-containing Ramsay broth tested by CFU mLâ�»Â¹ and Optical Density (OD) 600 nm at different concentrations of phenol. The results are 4.14 x 10â�¶ CFU mLâ�»Â¹, 3.58 x 10â�¶ CFU mLâ�»Â¹ and 3.46 x 10â�¶ CFU mLâ�»Â¹ ; 0.843, 0.804, and 0.817 respectively. Catechol 2.3 dioxygenase was used to detect the catabolism of phenol by meta- pathway. Yellow formations in both spray plate method and test-tube method showed that NAedEFBs-Cr1, NAdEFBus-Cr1), and RdEFBs-Cr1) degrade phenol via meta-pathway.
Facteurs de production du lait et caractéristiques des fromages. I. Influence des facteurs de production sur l'aptitude à la coagulation des laits de troupeaux

Les variations de la composition chimique et de l'aptitude a la coagulation des laits de troupeaux (n = 271) ont ete observees a l'echelle de la quinzaine pendant 18 mois chez 6 producteurs de fromage fermier (reblochon) du departement de la Haute-Savoie (France). Elles ont ete mises en relation avec les caracteristiques physiologiques et genetiques des animaux et les pratiques d'alimentation hivernales et estivales. La fermete du gel a ete fortement correlee au taux de proteines coagulables (R 2 = 0,72). Elle a varie sous l'effet du stade physiologique moyen du troupeau (R 2 = 0,50) et les gels les plus fermes ont ete associes aux niveaux d'apports energetiques les plus eleves. A meme taux de proteines coagulables, les gels les plus fermes provenaient d'une part des troupeaux caracterises par les frequences alleliques du variant B de la caseine κ les plus elevees, et d'autre part de la periode de pâturage ou les taux de calcium ont ete plus eleves. Le temps de gelification a varie de facon parallele au pH initial du lait (R 2 = 0,50). Il a diminue de 20% entre le 6 e et le 9 e mois de lactation et a ete plus court de 13% lorsque la frequence allelique du variant B de la β-lactoglobuline etait plus faible de 20%. La variabilite du temps de gelification des laits a egalement ete associee a la nature des aliments et aux modalites de leur distribution.
Ultrastructure of the spermatozoon of the tuatara sphenodon punctatus and its relevance to the relationships of the sphenodontida

Spermatozoa of the New Zealand tuatara , Sphenodon punctatus punctatus (Gray), are described from light and electron microscopic observations and compared with spermatozoa of other living ‘reptiles’ (Chelonia, Crocodilia, Squamata), birds and mammals. Mature Sphenodon spermatozoa consist of an acrosomal complex (length 4 µm), elongate, helical nucleus (54-56 µm), a relatively short midpiece (7-8 µm), elongate principal piece (74-78 µm) and short end piece (2-4 µm). The acrosomal vesicle and underlying subacrosomal material form a double, curved, conical sheath around the nucleus anteriorly. Two parallel, loosely helical, endonuclear canals each containing perforatorial material, extend posteriorly from the apex of the nucleus to at least 2.5 µm below the base of the acrosomal complex. Rings of several spherical mitochondria are stacked around the elongate distal centriole to form the midpiece. Each mitochondrion has concentric cristae surrounding a dense central body. Proximal and distal centrioles, although differing markedly in length, are similar in having triplets with an open C tubule. Nine peripheral fibres are intimately associated with the triplets of the distal centriole. A well developed annulus defines the posterior extremity of the midpiece. The principal piece consists of a 9 + 2 axoneme (accompanied anteriorly by nine peripheral fibres) surrounded by a highly electron-dense fibrous sheath and the plasma membrane. Absence of a penis in Sphenodon has not resulted in recognizable modifications of the spermatozoon. Sphenodon shares many spermatozoal features here interpreted as plesiomorphies with crocodiles and turtles, particularly the latter group, but exhibits none of the advanced character states (apomorphies) diagnostic of the Squamata. These data not only underscore the primitive status of living tuatara (recently questioned in the literature) but also militate against a close, sister-group relationship between the Sphenodontida and Squamata.
Medieval Monogamy

Was polygyny stopped by the Christian Church? Probably not. In the Middle Ages, as in other ages, powerful men married monogamously, but mated polygynously. Both laymen and church men tended to have sexual access to as many women as they could afford. But first-born sons were allowed a legitimate wife, on whom they got legitimate heirs. And latter-born sons were often celibate—that is, ineligible to sire heirs, though not chaste—that is, ineligible to sire bastards. Church men, like laymen, sought wealth to provide for their women and children. To get it, church men used canon law. Authorities like Gratian and Lombard insisted that “mutual consent” made a marriage. That undercut parents' ability to impose celibacy. And church bans against incest, divorce and remarriage, concubinage, wet nursing, and maybe even incontinence kept laymen from rearing heirs. That let the men who filled the monasteries come into their fathers' estates by default. In short, both church men and laymen practiced polygynous mating. At the same time, both approved of monogamous marriage. There was no conflict in either case. The conflict came when they tried to sow their seeds on the same finite plot. Neither wanted to get cut out of an inheritance.
Identification of Signature Predictive of Pathological Situation from Atherosclerosis Plaque Microarray Data

Large-scale gene expression analysis provides significance to the differentially expressed genes regulated in disease processes such as Atherosclerosis. Many targeting the promise of medical informatics by developing individualized diagnostic and therapeutic techniques for Atherosclerosis plaque will provide a detailed understanding about the genes and its variants that played an imperative role to this disease vulnerable and progression. A computational approach that accounts for genetic network, incorporates non- transcriptionally regulated genes, and accommodate foreseeing offers many advantages. We performed a comprehensive gene level estimation of performed prediction analysis for early and advanced condition of atherosclerosis plaque among 29 Atherosclerosis patients. Predictive signature profiles could be developed from normal tissues in humans and this is ambiguous and interchangeably sometimes it predicts as Diagnostic signature and in this it, reveals from advanced atherosclerosis plaque condition compares with early one. And after implicative analysis of microarrays to reveal gene ontology analyses and relative gene expression profiles. Our studies revealed that immune responsive genes is more up regulated in advance atherosclerosis patients as compared to early atherosclerosis patients and these gene expression is the elementary expression signature of disease progression in atherosclerosis plaque formation. Furthermore, we provide vision to the mutual genes interaction network of many clusters of genes associated with Atherosclerosis, revealing an overflow of immune and inflammatory signaling genes. We present a novel approach to future Pathway circuit designing based on connectivity approach. In doing this, we identify 1151genes of total genes are differentially expressing rest of many genes shows no variation in expression in early and advanced stages of Atherosclerosis that are preprocessing candidates for therapeutic targeting to future relevance. This study also provide significant insights over for systems-based approach to analyzing complex disease and also to evaluate global gene expression patterns in the common iliac arteries of monkeys with a diverse expansion of atherosclerosis vulnerabilities which is the basis of new medical informatics approaches in terms of their further drug development.
The Distribution of Free and Glycosidically-Bound Monoterpenes Among Skin, Juice, and Pulp Fractions of Some White Grape Varieties

The amount of free and glycosidically-bound forms of linalool, geraniol, nerol, α-terpineol, cis - and trans -furan linalool oxides, cis - and trans -pyran linalool, oxides, and diendiol I (3,7-dimethylocta-l,5-diene-3,7-diol) were determined in the skin, juice (serum), and pulp (pellet) fractions of mature Muscat of Alexandria, White Frontignac, and Traminer grapes. The pulp fractions of the grapes were found to have terpene compositions reflecting those of the juices. In all the varieties, free geraniol and nerol were associated mostly with the skins of the berries. Free linalool and diendiol I were uniformly distributed between skin and juice of the two muscats, and Traminer contained very little of either of these monoterpenes. Glycosylation effectively redistributes the monoterpenes throughout the berry fractions. The linalool oxides were lesser terpenes of the three varieties, with cis - and trans -furan linalool oxides present principally as glycosides in both skin and juice. The pyran linalool oxides were found mainly free in the juices. α-Terpineol and its glycosides were minor components of all the varieties. From the distribution patterns, it is clear that free aroma substances as well as potential flavorants of the grape are not concentrated solely in the skins of the berries but are present in the juice as well.
Impact of Bt Cotton on Animal Health: A Review

2 Abstract: Bacillus thuringiensis (Bt) cotton is commonly grown in all over the world to control wide range of pests. Bt cotton have several advantages over conventional chemical fertilizers and biological control methods as it provide safe, quick, efficient and long term resistance against diverse range of cotton insects. With the passage of time several technical, socio-economical, ethical and biosafety issues arises with use of Bt cotton. As Bt cotton adversely affects a variety of non targeted organisms including many beneficial animals. Several researchers have been reported that Bt toxins affect several different species of animals such as cows, buffaloes, model mice, goats, pigs, chickens, herbivores and human. The effect of Bt toxin is more lethal on Gastro Intestinal Tract (GIT) than other organs in all tested mammals that feed on Bt cotton seeds. Besides its usefulness, Bt toxin also interrupt normal biochemical and biological processes of many important animals. However some findings revealed that Bt toxins affect human lymphocytes and other physiological characters when used in higher concentration. Therefore, the present review is designed to describe the possible lethal effects of different types of Bt proteins on non-target animal species. The present study will be useful to minimize the toxicity associated with Bt cotton on wide ranges of animals.
Questions versus statements: Challenging an assumption about semantic illusions

In previous semantic-illusion research the tacit assumption has been that questions and statements-to-be-verified of similar semantic content lead to a similar proportion of semantic illusions. This assumption was made despite the fact that questions are thought to have different processing demands from those of statements. This paper presents empirical evidence that questions tend to lead to more semantic illusions than do statements-to-be-verified. Two experiments were carried out to provide a direct comparison between the semantic-illusion rates for statements and for questions. In Experiment 1, open-ended questions led to significantly more semantic illusions than did true/false statements. Experiment 2 replicated this effect using multiple-choice response options in the question condition. It is concluded that the syntactic form of a sentence affects the way in which semantic information is processed, and the implications of the findings are discussed.
Unpacking the Narrative Decontestation of CSR: Aspiration for Change or Defense of the Status Quo?

Corporate social responsibility (CSR) has repeatedly been described as an “essentially contested concept,” which means that its signification is subject to continuous struggle. We argue that the “CSR institution” (CSRI; i.e., the set of standards and rules regulating corporate conduct under the banner of CSR) is legitimized by narratives which “decontest” the underlying concept of CSR in a manner that safeguards the CSRI from calls for alternative institutional arrangements. Examining several such narratives from a structuralist perspective, we find them to be permeated with six recurrent ambiguities that we show to be reflective of three deep-set taboos: the taboo of the noncongruency between corporate profit objectives and societal needs, the taboo of multinational firms’ continued contribution to the emergence of global socioenvironmental issues, and the taboo of the CSRI’s moderate results in solving these problems. We contend that the perpetuation of these taboos contributes to inhibiting substantial change in the way of doing business, and we sketch out possibilities for initiating a “recontestation” of CSR’s meaning.
Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies

Cardiovascular diseases, including coronary artery disease, ischemic heart diseases such as acute myocardial infarction and postischemic heart failure, heart failure of other etiologies, and cardiac arrhythmias, belong to the leading causes of death. Activation of capsaicin-sensitive sensory nerves by the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor and other receptors, as well as neuropeptide mediators released from them upon stimulation, play important physiological regulatory roles. Capsaicin-sensitive sensory nerves also contribute to the development and progression of some cardiac diseases, as well as to mechanisms of endogenous stress adaptation leading to cardioprotection. In this review, we summarize the role of capsaicin-sensitive afferents and the TRPV1 ion channel in physiological and pathophysiological functions of the heart based mainly on experimental results and show their diagnostic or therapeutic potentials. Although the actions of several other channels or receptors expressed on cardiac sensory afferents and the effects of TRPV1 channel activation on different non-neural cell types in the heart are not precisely known, most data suggest that stimulation of the TRPV1-expressing sensory nerves or stimulation/overexpression of TRPV1 channels have beneficial effects in cardiac diseases.
Genetic interactions regulating seed phytate and oligosaccharides in soybean (Glycine max L.)

Two low-phytate soybean (Glycine max (L.) Merr. ) mutant lines– V99-5089 (mips mutation on chromosome 11) and CX-1834 (mrp-l and mrp-n mutations on chromosomes 19 and 3, respectively) have proven to be valuable resources for breeding of low-phytate, high-sucrose, and low-raffinosaccharide soybeans, traits that are highly desirable from a nutritional and environmental standpoint. A recombinant inbred population derived from the cross CX1834 x V99-5089 provides an opportunity to study the effect of different combinations of these three mutations on soybean phytate and oligosaccharides levels. Of the 173 recombinant inbred lines tested, 163 lines were homozygous for various combinations of MIPS and two MRP loci alleles. These individuals were grouped into eight genotypic classes based on the combination of SNP alleles at the three mutant loci. The two genotypic classes that were homozygous mrp-l/mrp-n and either homozygous wild-type or mutant at the mips locus (MIPS/mrp-l/mrp-n or mips/mrp-l/mrp-n) displayed relatively similar ~55% reductions in seed phytate, 6.94 mg g -1 and 6.70 mg g-1 respectively, as compared with 15.2 mg g-1 in the wild-type MIPS/MRP-L/MRP-N seed. Therefore, in the presence of the double mutant mrp-l/mrp-n, the mips mutation did not cause a substantially greater decrease in seed phytate level. However, the nutritionally-desirable high-sucrose/low-stachyose/low-raffinose seed phenotype originally observed in soybeans homozygous for the mips allele was reversed in the presence of mrp-l/mrp-n mutations: homozygous mips/mrp-l/mrp-n seed displayed low-sucrose (7.70%), high-stachyose (4.18%), and the highest observed raffinose (0.94%) contents per gram of dry seed. Perhaps the block in phytic acid transport from its cytoplasmic synthesis site to its storage site, conditioned by mrp-l/mrp-n, alters myo-inositol flux in mips seeds in a way that restores to wild-type levels the mips conditioned reductions in raffinosaccharides. Overall this study determined the combinatorial effects of three low phytic acid causing mutations on regulation of seed phytate and oligosaccharides in soybean.
Approximating the Gradient of Cross-Entropy Loss Function

A loss function has two crucial roles in training a conventional discriminant deep neural network (DNN): (i) it measures the goodness of classification and (ii) generates the gradients that drive the training of the network. In this paper, we approximate the gradients of cross-entropy loss which is the most often used loss function in the classification DNNs. The proposed approximations are noise-free, which means they depend only on the labels of the training set. They have a fixed length to avoid the vanishing gradient problem of the cross-entropy loss. By skipping the forward pass, the computational complexities of the proposed approximations are reduced to <inline-formula> <tex-math notation="LaTeX">$\mathcal {O}(n)$ </tex-math></inline-formula> where <inline-formula> <tex-math notation="LaTeX">$n$ </tex-math></inline-formula> is the batch size. Two claims are established based on the experiments of training DNNs using the proposed approximations: (i) It is possible to train a discriminant network without explicitly defining a loss function. (ii) The success of training does not imply the convergence of network parameters to fixed values. The experiments show that the proposed gradient approximations achieve comparable classification accuracy to the conventional loss functions and can accelerate the training process on multiple datasets.
Network Calculus Results for TSN: An Introduction

Time-Sensitive Networking (TSN) is a set of standards that enables the industry to provide real-time guarantees for time-critical communications with Ethernet hardware. TSN supports various queuing and scheduling mechanisms and allows the integration of multiple traffic types in a single network. Network Calculus (NC) can be used to calculate upper bounds for latencies and buffer sizes within these networks, for example, for safety or real-time traffic. We explain the relevance of NC for TSN-based computer communications and potential areas of application. Different NC analysis approaches have been published to examine different parts of TSN and this paper provides a survey of these publications and presents their main results, dependencies, and differences. We present a consistent presentation of the most important results and suggest an improvement to model the output of sending end-devices. To ease access to the current research status, we introduce a common notation to show how all results depend on each other and also identify common assumptions. Thus, we offer a comprehensive overview of NC for industrial networks and identify possible areas for future work.
A Preliminary Study on Effectiveness of a Standardized Multi-Robot Therapy for Improvement in Collaborative Multi-Human Interaction of Children With ASD

This research article presents a preliminary longitudinal study to check the improvement in multi-human communication of children with Autism Spectrum Disorder (ASD) using a standardized multi-robot therapy. The research is based on a 3 step framework: 1) Human-Human Interaction, Stage-1 (HHI-S1), 2) Human-Robot Interaction, Stage-2 (HRI-S2), and 3) Human-Human Interaction, Stage-3 (HHI-S3). All three stages of the therapy consist of two command sets: 1) Controls commands and 2) Evaluation commands (auditory commands, visual commands, and combination of both). The concept of multiple robots is introduced to help multi-human communication and discourage isolation in ASD children. The joint attention of an ASD child is improved by the robotic therapy in stage 2 considering it as a key parameter for a multi-human communication scenario. The improvement in joint attention results in better command following in a triad multi-human communication scenario in stage 3 as compared to stage 1. The proposed intervention has been tested on 8 ASD subjects with 10 sessions over a period of two and a half months (10 weeks). Each session of human-human interaction (stage 1 and 3) consisted of 14 cues whereas 18 cues were presented by each robot for human-robot interaction (stage 2). The results indicate an overall 86% improvement in the social communication skills of ASD children in case of a multi-human scenario. Validation of results and effectiveness of the therapy has been further accomplished through the use of the Childhood Autism Rating Scale (CARS) score.
Multicentre, randomized comparison of two-stent and provisional stenting techniques in patients with complex coronary bifurcation lesions: the DEFINITION II trial.

AIM The present study aimed to assess the benefits of two-stent techniques for patients with DEFINITION criteria-defined complex coronary bifurcation lesions. METHODS AND RESULTS In total, 653 patients with complex bifurcation lesions at 49 international centres were randomly assigned to undergo the systematic two-stent technique (two-stent group) or provisional stenting (provisional group). The primary endpoint was the composite of target lesion failure (TLF) at the 1-year follow-up, including cardiac death, target vessel myocardial infarction (TVMI), and clinically driven target lesion revascularization (TLR). The safety endpoint was definite or probable stent thrombosis. At the 1-year follow-up, TLF occurred in 37 (11.4%) and 20 (6.1%) patients in the provisional and two-stent groups, respectively [77.8%: double-kissing crush; hazard ratio (HR) 0.52, 95% confidence interval (CI) 0.30-0.90; P = 0.019], largely driven by increased TVMI (7.1%, HR 0.43, 95% CI 0.20-0.90; P = 0.025) and clinically driven TLR (5.5%, HR 0.43, 95% CI 0.19-1.00; P = 0.049) in the provisional group. At the 1 year after indexed procedures, the incidence of cardiac death was 2.5% in the provisional group, non-significant to 2.1% in the two-stent group (HR 0.86, 95% CI 0.31-2.37; P = 0.772). CONCLUSION For DEFINITION criteria-defined complex coronary bifurcation lesions, the systematic two-stent approach was associated with a significant improvement in clinical outcomes compared with the provisional stenting approach. Further study is urgently warranted to identify the mechanisms contributing to the increased rate of TVMI after provisional stenting. STUDY REGISTRATION http://www.clinicaltrials. com; Identifier: NCT02284750.