Miracle-dz/UniFAR-FTUs huggingface dataset:
Estudio poblacional de la mutación KRAS en pacientes con diagnóstico de cáncer de páncreas.

in English, 250 words or less): Pancreas cancer has a high mortality rate among the world population. In 90 % of the cases appears as a consequence of the mutation in the KRAS protein. In this work, a descriptive analysis a population study of the sequences of patients with pancreas carcinomas and other types of carcinomas have been carried out in order to evaluate the mutations that appear in the 2nd exon chromosome ́s 12 codon 12 the KRAS gene. A study has been done with of DNA where 26 of these sequences belong to pancreatic carcinoma and 69 belong to other types of carcimomas. All the sequences are discharged from the bank of genomics information. The results show that the averages of the mutations in pancreas carninomas are higher than in other kinds of carcinomas obtaining statistically significant differences
Design And Control Of Concrete Mixtures

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Design Neuro-Fuzzy On-line Tuning Controller for Sensitive Dental Actuator

In this research, Neuro-fuzzy fuzzy feedback linearization controller is recommended for sensitive three degrees of freedom dental actuator. To design stable high quality controller conventional feedback linearization controller is recommended. Conventional feedback linearization (FL) controller is a nonlinear, stable, and reliable controller. This controller is model-base and in uncertain situation, model-base is challenge. The nonlinear dynamic formulation problem in highly nonlinear system has been solved by fuzzy logic theorem. Fuzzy logic theory is used to estimate the system dynamics. This type of controller is free of mathematical dynamic parameters of plant. When system works in uncertainty, the nonlinearity term of system is not equal to equivalent term of FL controller. According to this technique, the number of rule base is reduced with respect to have PID like fuzzy logic controller. The simulation results show that the proposed controller works well in various situations. Based on result and discussion, proposed method can eliminate chattering in certain and uncertain condition. This controller reduces the level of energy due to the torque performance. This controller removed the fluctuation in presence of uncertainties.
Scalable scenario specifications to synthesize component-centric behaviour models

Several scenario description languages and associated behaviour synthesis processes have been developed. The goal of these is to synthesize behaviour models from system requirement specifications, in order to enable the early identification of weak design spots or code generation. To date, however, most of the scenario languages are poorly scaled with regards to system sizes. This is because scalability requires more expressive constructs that can help when writing a scenario specification in a concise and compact manner, thereby resulting in a reduced number of scenarios. Furthermore, due to a lack of expressiveness in scenario languages, synthesis algorithms may need to rely on global behaviour models to determine inter-scenario dependencies. The global model is an additional factor that limits the approaches' scalability. The reason is that the construction of a global model becomes harder as the system specification increases. To tackle these issues, within this article is proposed an expressive scenario description language that provides a concise and compact approach to scenario description, and defines inter-scenario dependencies semantically. A new algorithm that can address the additional constructs of the language was defined, in order to synthesize component-centric behaviour models. The applicability of this work has been demonstrated through both an illustrative example and a real-world case study. The evaluation indicates that the proposed scenario description language is more scalable than existing languages.
[E-Biomed: A Proposal for Electronic Publications in the Biomedical Sciences (Draft and Addendum)]

Varmus posted the May 5th draft of the E-Biomed proposal on the NIH server in May, and the addendum in June, following comments from many scientists. (As of September 2014, it could still be found by searching for "ebiomed," though the links to the comments and sources don't work anymore.)
Interference-Aware Spreading Factor Assignment Scheme for the Massive LoRaWAN Network

In LoRaWAN, end devices of class A adapts pure ALOHA for the channel access where interference occurs due to the use of same/different spreading factors (SFs) which leads to high packet loss. In this paper, we propose an Interference-Aware Spreading Factor Assignment (I-ASF) algorithm to counteract against the interference occurred due to the same/different SFs. The I-ASF algorithm considers gateway sensitivity, the interfered SFs, overlaps time of the collided packets, and the interfering energy in order to assign SF to decrease the significance of the interference. Thus, this behavior leads to an optimal assignment of SFs which minimizes the ToA for every end device. As a result, I-ASF reduces the collision and enhances the packet success ratio. Simulation results show that I-ASF algorithm outperforms both the existing distance-based and random-based spreading factor allocation schemes in terms of packet success ratio.
Knowledge on human papillomavirus and cervical cancer awareness among women in South India

Background: Cervical malignancy is a major health problem threatening women community in the developing countries. Aims: The main objective of this study is to investigate the awareness, knowledge of human papillomavirus (HPV) and cervical cancer (CC) risk factors among women. Methods: A cross-sectional, questionnaire-based, survey was conducted among females aged from 15 to 64 years in Tamil Nadu. It contained questions on sociodemographic data, awareness, knowledge of HPV and CC. Results and Conclusion: Of the 573 participants, only about 19% of women in Tamil Nadu were aware of CC and they know it is the second-most common gynecological cancer found among women in the country. About 14% of women were aware of HPV and HPV vaccine. Merely about 9% recognize that CC can be prevented and 7% say that HPV can be sexually transmitted. This study reveals that there is a low level of awareness and knowledge of HPV, CC among women in Tamil Nadu. The present study indicates the need for government organizations, health-care providers to join hands to educate middle-aged women with low educational status, create social awareness about the disease, its symptoms and reduce the risk of having CC in the population.
Determining the non-pharmacological methods using to cope with radiation-related oral mucositis in patients with head and neck cancer

Background & Aim: The radiation-related oral mucositis is common in patients with head and neck cancer. Patients trying pharmacological and non-pharmacological methods to cope with oral mucositis. In this study, it was aimed to determine the non-pharmacological methods in dealing with oral mucositis of head and neck cancer patients. Methods & Materials: In this descriptive study, the data were collected from a University Hospital's radiotherapy unit and a special cancer treatment center between June 2017 and October 2018. The study included 108 individuals aged 18 and over, who were diagnosed with head and neck cancer, could be communicated verbally and accepted to take part in the study during the study period. A convenience sample of patients was obtained from among all patients meeting the criteria for inclusion. A 20-item questionnaire (including the sociodemographic items, risk factors, oral mucositis history, and non-pharmacological methods) form developed by researchers were used in the study. The written permissions were obtained from the Ethics Committee of Ege University, Faculty of Nursing, the centers that research conducted and the participants. IBM Statistical Package for Social Science for Windows package program version 25.0 was used for analyzing the data. Results: Of the 108 individuals included in the study, 64.8% (n=70) were male. The mean age of the participants was 59.73±8.92. It was found that 58.3% (n=63) of the participants had mouth problems after starting treatment. 69.8% of the individuals who developed oral mucositis used a non-pharmacological method to cope with oral mucositis. The most commonly used non-pharmacological method was the mixture of carbonate and salt with 60.7%. The second most common method was black mulberry syrup with 37.7%. Other methods were including propolis, mulberry syrup, raspberry syrup, tea tree oil, thyme, and sumac. Conclusion: While some methods used by the patients were effective, the others were ineffective. Health professionals, especially nurses, requirement be informed about the non-pharmacological methods, therefore, they can guide the patients about using the right methods.
Window Processing of SSB CP-OFDM System for the OOB Spectrum Reduction

In order to provide the very fast eMBB (enhanced mobile broadband) service of the next generation mobile communication, it is important to increase the spectrum efficiency for accommodating the more channel capacity. To do this goal, it should have higher frequency efficiency than the existing mobile communication system. Numerous studies have been conducted and are still underway. In this paper, SSB (Single Side Band) modulation is applied into the existing CP (Cyclic Prefix)-OFDM (Orthogonal Frequency Division Multiplexing) as a modulation method to achieve higher frequency efficiency. Conventional SSB modulation is a method that can increase the frequency efficiency twice, because it transmits and receives using half spectrum using analog modulation method. However, it has a disadvantage that it is not easy to perform high-speed transmission compared with digital communication such as CP-OFDM. In this paper, we propose the SSB modulation with the CP-OFDM and sends different information signals to each of the two half spectrum. In addition, to reduce the OOB (Out of Band) power spectrum, the windowing technique is studied using various window functions with many different window lengths. As the simulation results show, As a result, we have confirmed that the BER performance of SSB-CP-OFDM and the spectral OOB power reduction by each window function and length. OOB power reduction of 63 dB can be found when the window length of 32 with the Kaiser window is used. Of course, the longer window length, the lower OOB power spectrum. However, it will be harmonized considering other design parameters.
Disease Activity, Occupational Participation, and Quality of Life for Individuals with and without Severe Fatigue in Ankylosing Spondylitis

Background Fatigue is one of the most frequently reported symptoms by individuals with ankylosing spondylitis. However, it is often overlooked clinically and in research. Literature researching the impact of severe fatigue on occupational participation in ankylosing spondylitis is limited. Therefore, the aim of this research was to explore the impact of severe fatigue on occupational participation, disease activity, and quality of life in people with AS. Methods A sequential exploratory mixed method study design was used in this study. Self-reported questionnaires gathered quantitative data which were analysed with descriptive and inferential statistics. Qualitative data were generated through semistructured interviews and analysed using a content analysis approach. Results Fifty individuals with AS completed all study questionnaires. Participants had a mean age of 46.5 years; 72% were men with a mean disease duration of 14.5 years. High fatigue was reported by 38% of participants using the Multidimensional Assessment of Fatigue (MAF). Fatigue was significantly associated with lower occupational participation (p = 0.018), higher disease activity (p < 0.001), higher pain (p < 0.001), reduced physical capacity (p = 0.018), lower quality of life (p < 0.001), and lower global well-being (p < 0.001). There were significant differences between those with low and high fatigue levels for occupational participation (p = 0.007), disease activity (p < 0.001), physical capacity (p = 0.015), pain (p < 0.001), and quality of life (p < 0.001). Participants discussed the impact of fatigue on productivity and leisure. They also discussed a range of strategies for managing their fatigue but reported a lack of education from health professionals on managing this symptom. Conclusion Severe fatigue is a prevalent symptom for individuals with ankylosing spondylitis and results in reduced occupational participation in productivity and leisure. Early fatigue management interventions may reduce the occupational participation impact of this symptom for individuals with ankylosing spondylitis.
Abstract 1632: Deep learning functional associations using histopathology images

Histopathological images have critical value for understanding cancer subtype, local structure, and malignancy. Manual interpretation of such images can be time-consuming and error-prone, while also failing to make use of the power of image aggregation for coordinated data mining. Large-scale patient cohorts such as TCGA provide high-resolution HE 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1632.
Iteration acceleration for the Kohn-Sham system of DFT for semiconductor devices

In Density Functional Theory the main object of relevance is the systems particle density, which, thanks to Hohenberg and Kohn [42], is known to uniquely determine the systems ground-state and all other properties. It was due to Kohn and Sham [57] to benefit from this information, by introducing a single-particle formulation for describing the multi-particle problem. For incorporating interaction effects, they included an exchange and correlation term in the effective potential. The resulting Kohn-Sham system is a nonlinearly coupled system of partial differential equations, that has to be solved self-consistently. In this work we are mainly interested in the quantum mechanical description of semiconductor heterostructures. Thus, we will look at the involved Schrodinger operator in effective mass approximation and have to deal with discontinuous coefficients and potentials. For numerically treating the Kohn-Sham system, we will use the fixed point formulation on basis of the particle density. A commonly used scheme for solving this problem is the well-known linear mixing scheme, that corresponds to a damped Picard (or Banach) iteration. However, this method is known to suffer from slow convergence and thus the use of acceleration methods is advised. Using well-established acceleration schemes based on the Newton-method, is possible, but the numerical costs for computing the needed information about the Jacobian are quite big. The aim of this work is the introduction of a fast and efficient acceleration method that generalises the linear mixing scheme to higher dimensions. The basis of our approach will be the direct inversion in the iterative subspace (DIIS) method from quantum chemistry. In Hartree-Fock and Coupled Cluster calculations DIIS is used to accelerate the calculation of electron orbitals. However, a straight forward transfer to our problem is dangerous. This is due to the extrapolation ability of the DIIS scheme, leading to negative mixing coefficients. Applied to our density approach, this may result in a negative density, meaning an iterate lying outside of the solution space. Thus, when applying the DIIS scheme to our problem, we have to ensure positivity of the produced density. We do this by introducing further constraints on the coefficients, that ensure positivity of the computed iterates. The resulting convex DIIS (CDIIS) scheme is then tested on exciton calculation in a three-dimensional quantum dot example. The results show, that the CDIIS method considerably accelerates the linear mixing approach, while in every step only a single function evaluation is performed. Thus, the CDIIS scheme accelerates the calculation while keeping the computational costs low and ensuring the quality of the iterates.
Common spatial pattern-based feature extraction from the best time segment of BCI data

Feature extraction is one of the most crucial stages in the field of brain computer interface (BCI). Because of its ability to directly influence the performance of BCI systems, recent studies have generally investigated how to modify existing methods or develop novel techniques. One of the most successful and well-known methods in BCI applications is the common spatial pattern (CSP). In existing CSP-based methods, the spatial filters were extracted either by using the whole data trial or by dividing the trials into a number of overlapping/nonoverlapping time segments. In this paper, we developed a CSP-based moving window technique to obtain the most distinguishable CSP features and increase the classifier performance by finding the best time segment of electroencephalogram trials. The extracted features were tested by using support vector machines (SVMs). The performance of the classifier was measured in terms of classification accuracy and kappa coefficient (κ) . The proposed method was successfully applied to the two-dimensional cursor movement imagery data sets, which were acquired from three healthy human subjects in two sessions on different days. The experiments proved that instead of using the whole data length of EEG trials, extracting CSP features from the best time segment provides higher classification accuracy and κ rates.
Relationship between physical activity, body mass index (BMI) and lipid profile of students in Ghana

Introduction In Ghana, there is no data regarding physical activity habits and lipid profiles of students. Therefore, the aim of this study was to investigate the relationship between physical activities, Body Mass Index (BMI) and lipid profile of students in Ghana. Methods Cluster and systematic sampling techniques were employed to recruit 120 students, aged 18 years and above. This cross-sectional study was carried out among students from the University of Ghana. Biochemical analysis was conducted analysing total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and triglycerides (TG) in serum samples. Anthropometry measurements were also taken and BMI calculated. The physical activities, undertaken over a 7-day period, by the students were assessed using the International Physical Activity Questionnaire (IPAQ). Results 31.7% and 21.7% of the students were overweight and obese respectively. 61.5% of the obese students were engaged in high level physical activity as compared to 45.5% and 36.8% of the normal and overweight students, respectively. Normal weight students and overweight students showed significant differences in means of TC; [(4.56 ± 0.930 mmol/L) and (5.06 ± 0.93 mmol/L), respectively] and also between normal weight group (4.54 ± 0.93 mmol/L) and the obese students (5.24 ± 1.18 mmol/L). Significant correlations were also observed between TG, TC and BMI; and TC and TG, HDL and a strong correlation between LDL and TC (r=0.967). Conclusion Strong correlations between BMI, physical activity and lipid profile indices among students in Ghana. Comprehensive efforts should be applied to reduce the incidence of CVDs among students.
Die EFSUMB-Leitlinien und Empfehlungen für den klinischen Einsatz des kontrastverstärkten Ultraschalls (CEUS) bei nicht- hepatischen Anwendungen

Citation for published version (APA): Sidhu, P. S. , Cantisani, V. , Dietrich, C. F. , Gilja, O. H. , Saftoiu, A. , Bartels, E. , Bertolotto, M. , Calliada, F. , Clevert, D-A. , Cosgrove, D. , Deganello, A. , D'Onofrio, M. , Drudi, F. M. , Freeman, S. , Harvey, C. , Jenssen, C. , Jung, E-M. , Klauser, A. S. , Lassau, N. , . Wijkstra, H. (2018). Die EFSUMB-Leitlinien und Empfehlungen für den klinischen Einsatz des kontrastverstärkten Ultraschalls (CEUS) bei nicht-hepatischen Anwendungen: Update 2017 (Kurzversion). Ultraschall in der Medizin, 39(2), 154-180. https://doi.org/10.1055/s-0044-101254
ADEQUACY OF AXILLARY LYMPH NODE CLEARANCE IN BREAST CARCINOMA: ARE WE ACHIEVING THE RECOMMENDED STANDARDS?

Introduction: In the setup of breast cancer management, axillary lymph node clearance plays a role in staging and planning of adjuvant chemotherapy and local control of cancer. Harvesting minimum of 10 lymph nodes for histopathological analysis is cut off value to consider a 90% certainty of a true negative axillary lymph node after axillary clearance. Aim: To assess the adequacy of axillary lymph node clearance considering influence of tumor factor (size, site, grade, type, lymphovascular invasion and hormonal and HER 2-NEU receptor status). Method: Retrospective analysis of histopathological report included 117 patients underwent mastectomy and axillary lymph node clearance from January 2011 to July 2016 in professorial surgical unit teaching hospital Jaffna. The analysis assessed the adequacy of the axillary lymph node clearance considering the influence of tumor factor. Results: Adequate axillary lymph node clearance was done in 89.7% (105). None of considered factors showed significance influence (p<0.05) except tumor type. Conclusion: Unit achieved desirable adequacy in axillary lymph node clearance, clearance adequacy is not associated with considered tumor factors except tumor type. Keywords: Axillary lymphnode clearance, Adequacy, Breast cancer, nodal status