Miracle-dz/UniFAR-FTUs huggingface dataset:
Prediction of clinical responses in a simulated phase III trial of Crohn's patients administered the antisense phosphorothioate oligonucleotide ISIS 2302: comparison of proposed dosing regimens.

ISIS 2302, an antisense phosphorothioate oligonucleotide (ODN) targeting human intercellular adhesion molecule-1 (ICAM-1) mRNA, is currently being evaluated for treatment of patients with Crohn's disease. From data collected in phase II clinical studies with ISIS 2302, validated population pharmacokinetic and exposure-response models were developed and used to simulate the plasma exposure and clinical response results for a proposed phase III trial design involving 100 patients treated with active drug and 50 patients treated with placebo. Simulated results of 1000 replications of the trial were calculated for various proposed dosing regimens. Overall, the simulated results indicated that a fixed dose regimen (250-400 mg, depending on patient sex and total body weight) given three times weekly provides both desirable ISIS 2302 plasma exposure and a high rate of clinical response in this patient population. However, the simulated results also suggest that inclusion of a larger number of patients than projected may be necessary to provide a desirable probability of study success (i.e., >80%), regarding demonstration of statistically significant differences between the active treatment and placebo groups for the primary clinical response measure (CCR rate).
Multi-Sensor Surveillance of Indoor Environments by an Autonomous Mobile Robot

In this paper, we present our autonomous mobile robotic system for surveillance of indoor environments. The robot is equipped with a monocular camera, a laser scanner, encoders, and an RFID device, connected to a multi-layer decision and control scheme. Two main functions are implemented: to build a map of the environment, identifying specific areas of interest, marked by RFID tags; to monitor the target zones to detect unexpected changes, such as object addition or removal, based on a vision scene change detector (V-SCD) and a laser scene change detector (L-SCD). Fuzzy logic is used to integrate information provided by the different sensors. Applications of the proposed system include surveillance of wide areas, such as airports and museums, and monitoring of safety equipment. The feasibility of the approach is demonstrated through experimental tests, performed in the ISSIA Mobile Robotics Laboratory of Ban, Italy. The results are promising, proving the method to be effective in detecting either new or removed objects in the surveyed scene, also in presence of relatively small viewpoint changes. It is shown that the proposed robotic surveillance system successfully addresses a number of specific problems related to environment mapping, autonomous navigation, and scene processing, and can be potentially employed in real world surveillance applications.
Calcium sensors as new therapeutic targets for asthma and chronic obstructive pulmonary disease

In this thesis, the effects of the two calcium -like peptides CALP1 and CALP2 on several cell types involved in asthma are examined. Furthermore, we tested the effects of these peptides in a guinea pig model for allergic asthma. Calcium is a key secondary messenger, whose function is tightly regulated by the calcium-sensing regulatory protein calmodulin (CaM). CALPs are peptides which specifically bind to the calcium -binding sites, the EF-hands, of CaM. Specific modulation of calcium and/or CaM-regulated processes provides insights into processes such as cell signalling. Specifically, CaM modulates the intracellular calcium concentration, since CaM regulates the opening and closing of calcium channels present in non-excitable cells. Asthma is a chronic airway disease characterized by airway obstruction, airway hyperresponsiveness and most importantly, inflammation. The disease affects about 10% of the population, and the prevalence is rising in many parts of the world, especially in children. Cells involved in the pathophysiology of asthma include airway epithelial cells, mast cells and inflammatory cells. In this thesis we show that CALP1 blocks mast cells mediator release, inhibits the release of epithelium-derived relaxing factors and presumably attenuates radical production by alveolar macrophages in vivo. CALP2, on the other hand, blocks mast cell mediator release, increases the release of NO by airway epithelial cells and markedly increases radical production by alveolar macrophages in vitro, and most likely also in vivo. Taken together, these peptides have both beneficial and detrimental effects on cells involved in the pathogenesis of asthma. Thus, neither CALP1 nor CALP2 seem to be candidates for therapeutic interventions in asthma. However, although more research has to be performed to elucidate the exact mechanism of action of these peptides, some indirect evidence has been obtained that store-operated calcium channels are crucial in this mechanism. Therefore, specific modulation of store-operated calcium influx might be a target for future therapy against asthma. CALPs can serve as useful tool to further explore the role of these calcium channels in asthma.
Tracheal collapse in the dog: a review of the literature and report of two new cases.

Forty-two cases of tracheal collapse in the dog are reviewed and two new cases are reported. Aspects of the condition studied were age incidence, length of illness, diagnosis and treatment. Diagnosis depends on breed predisposition, long period of respiratory distress, radiography and bronchoscopy. Various surgical treatments are discussed. Resume. Quarante-deux cas d'affaissement tracheal sont examines et deux nouveaux cas sont rapportes. La maladie a ete etudiee a la lumiere de l'incidence de l'âge, de la duree de la maladie, du diagnostic et du traitement. Le diagnostic depend de la predisposition de la race, de la longue periode de contrainte eprouvee lors de la respiration, de la radiographie et de la bronchoscopie. Differents traitements chirurgicaux sont examines. Zusammenfassung. 42 Falle von Trachealkollaps beim Hund werden besprochen und zwei neue Falle werden beschrieben. Die betrachteten Aspekte des Zustands waren die Haufigkeit in Abhangigkeit vom Alter, die Krankheitsdauer, Diagnose und Behandlung. Die Diagnose ist von der Disposition der Hunderasse, einer langen Zeit der Atembeschwerden und radiographischen und bronchoskopischen Ergebnissen abhangig. Verschiedene chirurgische Behandlungsmethoden werden besprochen.
Ontology-based Context Modeling to Facilitate Reasoning in a Context-Aware System: A Case Study for the Smart Home

A context-aware system provides services based on the current context of the environment and user activities. So, context management and reasoning in context-aware systems are important tasks. A formal context model based on ontology can play a vital role in facilitating reasoning by formally representing domain knowledge. This paper presents an ontology-based reusable generic context model for context-aware systems. This model provides a context vocabulary and structure for contexts and their semantics which are essential for reasoning. We evaluate the effectiveness of this model for both ontology and rule-based reasoning in the smart home domain and the result we obtain is promising.
The extreme mutator effect of Escherichia coli mutD5 results from saturation of mismatch repair by excessive DNA replication errors.

Escherichia coli mutator mutD5 is the most potent mutator known. The mutD5 mutation resides in the dnaQ gene encoding the proofreading exonuclease of DNA polymerase III holoenzyme. It has recently been shown that the extreme mutability of this strain results, in addition to a proofreading defect, from a defect in mutH, L, S‐encoded postreplicational DNA mismatch repair. The following measurements of the mismatch‐repair capacity of mutD5 cells demonstrate that this mismatch‐repair defect is not structural, but transient. mutD5 cells in early log phase are as deficient in mismatch repair as mutL cells, but they become as proficient as wild‐type cells in late log phase. Second, arrest of chromosomal replication in a mutD5‐dnaA(Ts) strain at a nonpermissive temperature restores mismatch repair, even from the early log phase of growth. Third, transformation of mutD5 strains with multicopy plasmids expressing the mutH or mutL gene restores mismatch repair, even in rapidly growing cells. These observations suggest that the mismatch‐repair deficiency of mutD strains results from a saturation of the mutHLS‐mismatch‐repair system by an excess of primary DNA replication errors due to the proofreading defect.
Family of energy management system for smart grid

Energy management system (EMS) utilizes information flow to control power flow in order to balancing and optimizing the power flow every moment and place. Conventionally, the EMS is centralized one. However the architecture of future EMS is distributed & autonomous, interactive & coordinated. A new concept and architecture of future EMS for smart girds, i.e. EMS family, are proposed. Some new members of EMS family are introduced for autonomous and fast energy management of smart grids, for example, substation EMS, wind farm EMS and electric vehicle (EV) EMS. Interaction among EMS family members is introduced to do coordinated control in order to accumulating large-scale renewable energy as much as possible and to enhance entire gird security, which forms an EMS family network, for example, interaction between transmission and distribution grids, interaction between substation and control center, interaction between wind and EV. Implementation of demonstrative applications of such an EMS family will be carried out in several power grids in China in the near future.
Relationship of sidechain hydrophobicity and α‐helical propensity on the stability of the single‐stranded amphipathic α‐helix

The aim of the present investigation is to determine the effect of α‐helical propensity and sidechain hydrophobicity on the stability of amphipathic α‐helices. Accordingly, a series of 18‐residue amphipathic α‐helical peptides has been synthesized as a model system where all 20 amino acid residues were substituted on the hydrophobic face of the amphipathic α‐helix. In these experiments, all three parameters (sidechain hydrophobicity, α‐helical propensity and helix stability) were measured on the same set of peptide analogues. For these peptide analogues that differ by only one amino acid residue, there was a 0.96 kcal/mole difference in α‐helical propensity between the most (Ala) and the least (Gly) α‐helical analogue, a 12.1‐minute difference between the most (Phe) and the least (Asp) retentive analogue on the reversed‐phase column, and a 32.3°C difference in melting temperatures between the most (Leu) and the least (Asp) stable analogue. The results show that the hydrophobicity and α‐helical propensity of an amino acid sidechain are not correlated with each other, but each contributes to the stability of the amphipathic α‐helix. More importantly, the combined effects of α‐helical propensity and sidechain hydrophobicity at a ratio of about 2:1 had optimal correlation with α‐helix stability. These results suggest that both α‐helical propensity and sidechain hydrophobicity should be taken into consideration in the design of α‐helical proteins with the desired stability.
KEY FACTORS FOR SUSTAINABLE RATIONAL USE OF MEDICINE PROGRAM IN GUNUNGKIDUL AND SLEMAN DISTRICTS, INDONESIA

Â Objective: Many of the rational use of medicines (RUM) interventions have been proven effective in improving medicine use, but the impacts were usually not sustainable for longer period of time. Gunungkidul and Sleman Districts of Indonesia have succeeded in implementing RUM program for more than two decades. This is considered rare, and therefore, it is important to identify factors contributing to the success. Methods: This is a single case study with non-experimental exploratory design. Quantitative and qualitative data were collected integratively to obtain information concerning the indicators and the process of RUM implementation. Quantitative data were collected in reference to the World Health Organization (WHO) 1993 RUM indicators, including average number of medicines per prescription (polypharmacy), percentage of patients receiving antibiotics, and percentage of patients receiving injections. Qualitative data were analyzed descriptively and were arranged chronologically in respective to each district. Results: Implementation of RUM in the two districts has successfully lasted up to 20 years. The annual medicine use indicators from 1994 to 2014 in Gunungkidul District show that polypharmacy decreased from 4.2 to 2.89, percentage patients receiving injections declined from 68.05% to 0%, and percentage of patients receiving antibiotics improved from 52.1% to 24.1%. The same indicators in Sleman District show that, between 1998 and 2014, polypharmacy remained stable at 3, percentage of patients receiving injections declined from 4.9% to 0.18%, and percentage of patients receiving antibiotics improved from 44.31% to 20%. Culturization of RUM program is the main key for sustainable impacts. Another important key is the high commitment of health policymakers to implement the principles of evidence-based treatment. Conclusions: The culturization of RUM program followed by continuous monitoring and evaluation by district health managers were the key factors to maintain the impact of the intervention.
Effectively Settling SMEs financing Difficulty with Warehouse Receipt-a Case from China

: SMEs financing is a difficult problem in the world, and it is more difficult in China. The highlight of our paper is that it offers a route which could settle the difficult problem but loan on credit. There are three platforms which can effectively settle SMEs financing difficulty with warehouse receipt. Platform 1 is a warehouse receipt management platform which manages SMEs movable property. Platform 2 is a P2P platform, or warehouse receipt financing platform. Platform 3 is a transaction platform of warehouse receipt. Future works have been put in the end.
TakeLab at SemEval-2017 Task 6: #RankingHumorIn4Pages

This paper describes our system for humor ranking in tweets within the SemEval 2017 Task 6: #HashtagWars (6A and 6B). For both subtasks, we use an off-the-shelf gradient boosting model built on a rich set of features, handcrafted to provide the model with the external knowledge needed to better predict the humor in the text. The features capture various cultural references and specific humor patterns. Our system ranked 2nd (officially 7th) among 10 submissions on the Subtask A and 2nd among 9 submissions on the Subtask B.
Online co-creation: comparative pilot study on Poland, Ukraine and Spain

The article presents the process of co-creation on the Internet as an innovative method of product and service innovation development by modern companies. The aim of the article is to present the process of co-creating products on the Internet based on desk studies and own pilot surveys conducted on respondents from three countries: Poland, Ukraine and Spain. The research methods included: desk research, online diagnostic survey in three countries, and statistical methods. The hypothesis is made that the participation of contributors is higher for longer traditions of using the Internet and availability of the Internet in a given country. The main respective hypothesis, which has a high degree of generality, could not be confirmed by the analysis of the rather limited amount of data collected through the survey. To properly test this hypothesis, a considerably wider sample would have been required. However, specific hypotheses have been confirmed or partially confirmed. On the basis of deliberations, author’s division of the online co-creation process into stages was also presented. The conclusions provide recommendations for entrepreneurs intending to engage their clients in products and services co-creation on the Internet and the opportunities for further research.
Language and the Internet

A solution to get the problem off, have you found it? Really? What kind of solution do you resolve the problem? From what sources? Well, there are so many questions that we utter every day. No matter how you will get the solution, it will mean better. You can take the reference from some books. And the language and the internet is one book that we really recommend you to read, to get more solutions in solving this problem.
Imagerie optique dans les milieux fortement diffusants par modulation ultrasonore du speckle : application aux tissus biologiques

L'imagerie optique a travers les tissus biologiques constitue un nouveau defi, porteur d'espoir pour le diagnostic medical. Nous avons developpe dans le cadre de ce travail de these une methode originale d'imagerie combinant les ondes optiques et acoustiques. Le principe de cette imagerie est de marquer les photons passant dans un petit volume de l'echantillon delimite par la zone focale d'un transducteur ultrasonore : l'application du champ ultrasonore focalise induit des variations d'indice et des deplacements des diffuseurs qui modulent le speckle dont la source est la diode laser illuminant le milieu biologique. Cette imagerie acousto-optique, ou le champ acoustique focalise fournit la resolution du systeme, permet de contourner le probleme de la forte diffusion optique des tissus. Pour chaque position de la zone focale a l'interieur du tissu, la proportion de photons emergeants et ayant traverse cette zone qui est liee aux proprietes optiques locales. On peut ainsi obtenir une cartographie du contraste optique du tissu. Les origines physiques du signal acousto-optique et son comportement en fonction de differents parametres ont ete etudies. Nous avons egalement montre les differents avantages lies a l'utilisation d'une camera ccd associee a une detection synchrone multiplexee, qui permet de traiter en parallele la modulation d'un grand nombre de grains de speckle. Le fonctionnement et l'implantation de la detection multiplexee ont ete decrits ainsi que les differents elements du montage. La flexibilite du montage a ete demontree, il peut aussi bien fonctionner en transmission qu'en retrodiffusion. Differents moyens d'optimiser le rapport signal sur bruit du systeme ont ete evoques. Cette methode a ete utilisee pour
Extracellular but not intracellular calcium mobilization is required for epstein‐barr virus‐containing supernatant‐induced b cell activation

Changes in intracytosolic free calcium concentration ([Ca2+]i) are thought to be an important trigger for the initiation of the cellular events culminating in B cell activation. After exposure of human B lymphocytes loaded with the fluorescent indicator quin‐2 to the Epstein‐Barr virus (EBV)‐containing supernatant of B95‐8 cell line, a rise in [Ca2+]i is observed. To determine the respective contribution of the intra‐ and extracellular Ca2+ pools in EBV‐induced B cell activation, the pharmacologic modulation of these processes was investigated using an intracellular calcium chelator, 1,2‐bis(o‐aminophenoxy)ethane‐N,N,N',N'‐tetraacetic (BAPTA) or the calcium channel blocking drugs. When the extracellular Ca2+ contribution was minimized in the presence of calcium channel‐blocking drugs or incubation of the cells in Ca2+‐free medium, the EBV‐induced human B cell activation was fully inhibited. When the calcium channel‐blocking drugs, either verapamil or diltiazem, were withdrawn or when exogenous Ca2+ was added to the Ca2+‐free medium, EBV‐induced B cell activation was noted, demonstrating the reversibility of the inhibition. On the contrary, when the intracellular Ca2+ contribution was reduced after loading the cell with BAPTA, no alteration of the EBV‐induced B cell activation was observed. Thus, the EBV‐induced rise of [Ca2+]i required in the activation of human B cells appears to be essentially related to the entry of extracellular Ca2+ and not to the release of Ca2+ from internal stores.
PIGMENTED CELLS in MOSQUITOS

7. The exclusion of the liver from the circulation diminishes the amount of sugar in the blood. (a) Schenck"' showed that after bleeding there is an increase of sugar in the blood, but that this does not occur after excluaion of the liver by ligature, and that it is veiy small in starving animals, where, of course, the glycogen stored in the Hver is small in amount. (b) Tangl and Harley17 showed that, in dogs fed on flesh,ligature of the intestinal arteries diminished the amount of sugar in the blood. Here the supply of sugar from without was, from the nature of the diet, cut off before the operation, but it was only when the blood supply to the liver was interrupted that the amount of glucose in the blood fell. Even in prolonged starvation the amount of sugar in the blood is not diminished. How, if the kidneys are constantly excreting it, and if it is not being constantly manufactuied in the body, is this supply kept up ?
Is Ecuador ready to change its productive matrix?: an analysis of the Ecuadorian innovation system

Through a review of the Ecuadorian science, technology and innovation surveys and of several empirical studies on Ecuador; this article describes the Ecuadorian business sector, its science and technology organizations and their interactions; with the objective of examining the capacity of the Ecuadorian innovation system to move towards a productive structure based on the use of knowledge. The analysis indicates that Ecuador does not yet have an innovation system with learning capacity, which allows such a transition, when the technological conditions are propitious.
The Significance of Consumer Responses to Packaging Attributes of Giftware Design as Drivers of Business Innovation Growth in Malaysia

In today’s massive rapid changes in consumer’s demand and purchase desires, consumer responses to packaging attributes are significant for the businesses. It creates better relationship with consumers, producing new ideas to enhance business’ marketing performances, strategies and innovation growth. However, when entering Malaysian unique market because it is multiracial country, the marketers and designers must aware of its complex social behaviour in order to build strong relationship with consumers. This paper presents selected findings of doctoral research exploring how SMEs in Malaysia leveraging on packaging attributes of giftware design to enhance consumer’s involvement with product and emphasising consumers’ responses as drivers for business innovation growth from a management point of view. A qualitative method was conducted with in- depth interviews with three companies to examine how local SME’s develop packaging attributes of giftware design to fulfil specific consumer needs and influence their purchase intention in Malaysia. The results show that consumer responses about packaging attributes of giftware design such as colour, typography, ease of use, materials and shape can generate positive or negative responses and significant role to influence their purchase intentions. The main conclusion of this paper is significant for businesses and marketers to show the impact of packaging attributes of giftware design can establish an effective competitive marketing strategies and using consumer responses from packaging attributes offerings as a driver business innovation growth in the right direction.