Miracle-dz/UniFAR-FTUs huggingface dataset:
Diseño y desarrollo de una herramienta de extracción y procesado de información volumétrica a partir de imágenes de OCT macular para la evaluación del pronóstico visual en pacientes

La aparicion de patologias a nivel retinal en pacientes con discapacidad visual es un hecho relevante que afecta a un porcentaje elevado de la poblacion mundial. El campo de la oftalmologia, en las ultimas decadas, ha tenido numerosos avances y ha sido participe de diversos cambios producidos en el mundo de la medicina. Estos avances se han visto motivados por la aparicion de adelantos tecnologicos en el sector, asi como la introduccion de nuevas tecnicas y modalidades de imagen, con la finalidad de mejorar los metodos de diagnostico, tratamientos y, en definitiva, el cuidado del paciente. La tomografia de coherencia optica (OCT) es una tecnica moderna que ha supuesto, en los ultimos anos, un avance clave en el campo de la oftalmologia. Con esta nueva tecnica, la visualizacion de la vascularizacion de la retina y de las diferentes capas que la componen, entre otras diversas estructuras oculares que pueden verse afectadas por ciertas patologias, supone un apoyo vital para la rutina hospitalaria de los medicos oftalmologos y el resto del personal sanitario. La segmentacion de imagenes de OCT retinal y la extraccion de caracteristicas volumetricas de distintos componentes retinales a partir de dichas imagenes, suponen tareas complejas, pero a la vez de gran utilidad para conseguir un diagnostico y tratamiento completo y eficaz que garantice una mejora considerable en la calidad de vida y el bienestar del paciente. En este Trabajo de Fin de Grado se ha disenado y desarrollado una herramienta completa e intuitiva de extraccion y procesado de informacion volumetrica a partir de imagenes de OCT macular, que permite realizar una evaluacion rigurosa y objetiva del pronostico visual en pacientes que presentan alguna forma de discapacidad visual causada por patologias a nivel de la macula. El uso de la herramienta ha permitido analizar de forma objetiva las modificaciones en las capas de la retina tras la intervencion quirurgica de pacientes con membranas epirretinianas (ERM) en un estudio clinico preliminar. Los resultados preliminares obtenidos en dicho estudio demuestran que el volumen, y por tanto el grosor, de la retina de pacientes con ERM se ve reducido tras un proceso de vitrectomia y extraccion de la ERM de su superficie interna. Por todo ello, se pretende que los medicos oftalmologos, mediante el procesamiento y analisis de este tipo de imagenes, puedan complementar sus diagnosticos actuales con la informacion adicional extraida con esta aplicacion.
Antiangiogenic-specific adverse events (AEs) in patients with non-small cell lung cancer (NSCLC) treated with nintedanib (N) and docetaxel (D).

8100 Background: Antiangiogenic treatments, including monoclonal antibodies and TKIs, have shown activity in tumors; however, their use is limited in part by their characteristic side effects (eg, bleeding, thrombosis, perforation, serious skin reactions, hypertension). N is an oral, twice-daily, triple angiokinase inhibitor. Here we extend our investigation of the LUME-Lung 1 study (ClinicalTrials.gov NCT00805194) and evaluate whether adding N to standard second-line D increases the frequency of characteristic adverse events (AEs) associated with antiangiogenic agents and whether these AEs restrict the use of N. Methods: LUME-Lung 1, a randomized, placebo-controlled Phase III trial investigating N + D in patients with advanced NSCLC after failure of first-line chemotherapy, demonstrated significant PFS improvement regardless of histology and showed significant survival improvement for patients with adenocarcinoma histology. The incidence and intensity of antiangiogenic-associated AEs according to the com.
PENGEMBANGAN DUSUN EKOWISATA DI DUSUN SELOKURUNG DESA KAUMREJO KECAMATAN NGANTANG KABUPATEN MALANG

Pariwisata pedesaan menjadi dorongan baru agar semua daerah dapat mengembangkan daya tarik wisatanya. Hal tersebut menjadi alternatif baru sekaligus menambah diversifikasi produk dalam industri pariwisata. Pengembangan konsep desa wisata dianggap strategis untuk menjawab beberapa agenda dalam pembangunan kepariwisataan terdapat 3 (tiga) faktor yang mendasari pentingnya pengembangan desa wisata diantaranya pariwisata menjadi sektor prospektif di masa depan, munculnya tren dan motivasi perjalanan wisata minat khusus, serta pengembangan daya produktif lokal untuk mendorong pengembangan wilayah dan ekonomi masyarakat. Daya tarik utama desa bagi wisatawan adalah pada budaya, adat istiadat yang unik, serta kehidupan sehari-hari yang menarik. Selanjutnya, dengan konsep ini masyarakat desa yang memiliki kemampuan ekonomi kurang dapat berperan aktif dalam pengelolaan desa wisata. Ekowisata merupakan suatu bentuk wisata yang sangat erat dengan prinsip konservasi, bahkan dalam strategi pengembangan ekowisata juga menggunakan strategi konservasi, dengan demikian ekowisata sangat tepat dalam mempertahankan keutuhan dan keaslian ekosistem di areal yang masih alami. Bahkan dengan ekowisata pelestarian alam juga dapat ditingkatkan kualitasnya karena desakan dan tuntutan dari para eco-traveler . Dalam ekowisata pengelolaan alam dan budaya masyarakat yang menjamin kelestarian dan kesejahteraan, sementara konservasi merupakan upaya menjaga kelangsungan pemanfaatan sumber daya alam untuk masa sekarang dan masa yang akan datang, hal tersebut sejalan bahwa konservasi adalah usaha manusia untuk memanfaatkan biosphere dengan berusaha memberikan hasil yang besar dan lestari untuk generasi kini dan mendatang . Kata -kata K unci : desa wisata, ekowisata, konservasi
Using REDCap to track stakeholder engagement: A time-saving tool for PCORI-funded studies

Abstract Background: Research Electronic Data Capture (REDCap) is a secure, web-based electronic data capture application for building and managing surveys and databases. It can also be used for study management, data transfer, and data export into a variety of statistical programs. REDcap was developed and supported by the National Center for Advancing Translational Sciences Program and is used in over 3700 institutions worldwide. It can also be used to track and measure stakeholder engagement, an integral element of research funded by the Patient-Centered Outcomes Research Institute (PCORI). Continuously and accurately tracking and reporting on stakeholder engagement activities throughout the life of a PCORI-funded trial can be challenging, particularly in complex trials with multiple types of engagement. Methods: In this paper, we show our approach for collecting and capturing stakeholder engagement activities using a shareable REDCap tool in one of the PCORI’s first large pragmatic clinical trials (the Comprehensive Post-Acute Stroke Services) to inform other investigators planning cluster-randomized pragmatic trials. Benefits and challenges are highlighted for researchers seeking to consistently monitor and measure stakeholder engagement. Conclusions: We describe how REDCap can provide a time-saving approach to capturing how stakeholders engage in a PCORI-funded study and reporting how stakeholders influenced the study in progress reports back to PCORI.
A Transcendental Phenomenological Study of Student Nurses With Learning Disabilities in the Clinical Learning Environment

The purpose of this transcendental phenomenological study was to record the lived experiences of nursing students with learning disabilities while in the clinical learning environment. Dewey’s theory of education and Knowles’ theory of adult learning were used to ground this study. Their theories provided a foundation to understand how the learning process is affected in nursing students with learning disabilities in the clinical learning environment. The study answered the following research questions: (a) What are the lived experiences of student nurses with learning disabilities in the clinical learning setting? (b) How are nursing students impacted by their learning disability during clinical learning experiences? (c) What are perceived obstacles that hinder nursing students with learning disabilities during clinical learning experiences? and (d) What are reasonable accommodations or solutions for students with learning disabilities during clinical learning experiences? Data collection for this study included student interviews, audio memos of the students’ descriptions of their lived experiences, and analysis of documents. Data was analyzed and coded using Moustakas’ (1994) transcendental phenomenological model and revealed the themes of negative emotions, disclosure, hands-on, negative faculty members, difficulties/obstacles, and determination. Implications for schools of nursing, nursing faculties, and nursing students with learning disabilities are discussed, and recommendations for areas of future research are included.
Association of VEGFA SNP rs2010963 with prognosis and prediction of vascular toxicity of bevacizumab in recurrent glioblastomas.

2028 Background: VEGFA has become an attractive target in high grade gliomas but there is no predictor of response or toxicity to anti-VEGF therapy. We investigated here the association between functional single nucleotide polymorphism (SNP) +405 G>C (rs2010963), located in 5’ untranslated terminal region of VEGFA gene, survival, response to bevacizumab (BVZ), and vascular toxicity. Methods: The rs2010963 was analyzed in blood DNA using a Taqman SNP Genotyping Assay and confronted to Progression Free Survival (PFS), Overall Survival (OS) in the general population of gliomas, and -for the glioblastomas (GBM) treated with BVZ at recurrence- with Response, PFS, and thrombo-hemorragic events. Results: In the general population of 954 gliomas stratified per grade (362 grade 2, 269 grade 3, 323 grade 4) there was no association between rs2010963 and OS or PFS. In the population of 123 recurrent GBM treated with BVZ, we observed a favourable trend in PFS associated with the C allele of rs2010963 (5.4 vs 4.2 mont.
Arabidopsis AZG2, an auxin induced putative cytokinin transporter, regulates lateral root emergence

The phytohormones cytokinin (CK) and auxin are key regulators of plant growth and development. During the last decade specialised transport mechanisms turned out to be the key for the control of local and long distance hormone distributions. In contrast to auxin, CK transport is poorly understood. Here we show that Arabidopsis thaliana AZG2, a member of the AZG purine transporter family, acts as CK transporter involved in the determination of the root system architecture. The expression of AtAZG2 is primarily auxin dependent and restricted to a small group of cells surrounding the lateral root primordia. Compared to wild type, mutants carrying loss-of-function alleles of Atazg2 have higher density of lateral roots, suggesting AZG2 as being part of a regulatory pathway in lateral root emergence. Moreover, azg2 mutants are partially insensitive to exogenously applied CK, which is consistent with the observation that the CK reporter gene TCSnpro:GFP showed lower fluorescence signal in the roots of azg2 mutants compared to those of wild type. These results indicate a defective CK signalling pathway in the region of lateral root primordia. By the integration of AtAZG2 subcellular localization and CK transport capacity data, our results allowed us to propose a local Auxin/CK signalling model for the regulation of lateral root emergence.
Poly(3,4-Ethylenedioxythiophene) Nanoparticles as Building Blocks for Hybrid Thermoelectric Flexible Films

Hybrid thermoelectric flexible films based on poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles and carbon nanotubes were prepared by using layer-by-layer (LbL) assembly. The employed PEDOT nanoparticles were synthesized by oxidative miniemulsion polymerization by using iron(III) p-toluenesulfonate hexahydrate (FeTos) as an oxidant and poly(diallyldimethylammonium chloride) (PDADMAC) as stabilizer. Sodium deoxycholate (DOC) was used as a stabilizer to prepare the aqueous dispersions of the carbon nanotubes. Hybrid thermoelectric films were finally prepared with different monomer/oxidant molar ratios and different types of carbon nanotubes, aiming to maximize the power factor (PF). The use of single-wall (SWCNT), double-wall (DWCNT), and multiwall (MWCNT) carbon nanotubes was compared. The Seebeck coefficient was measured by applying a temperature difference between the ends of the film and the electrical conductivity was measured by the Van der Pauw method. The best hybrid film in this study exhibited a PF of 72 µW m−1K−2. These films are prepared from aqueous dispersions with relatively low-cost materials and, due to lightweight and flexible properties, they are potentially good candidates to recover waste heat in wearable electronic applications.
Uso de imagens do Landsat 8 para determinação da correlação entre a temperatura de superfície e o índice de vegetação em Municípios da Grande Vitória

This paper presents the findings of the study for evaluating the correlation between the Land Surface Temperature (LST) and the presence of vegetation cover, identified by the Normalized Difference Vegetation Index (NDVI). Therefore, the researchers used images from LANDSAT 8 (L8) satelite, specifically, the spectral bands 4, 5 and 10 were used, whose capture dates the September 27th of 2016. These bands represent, respectively, the red band (0,64 – 0,67 μm), the near infrared band (0,85 – 0,88 μm) and the thermal infrared band (10,60 – 11,19 μm). The studied area encompasses the following counties of the main metropolitan area of the state of Espírito Santo: Vitória, Vila Velha and Serra, with a 10 km buffer surrounding it’s political limits, including, thus, part of the neighboring counties and also a sea track. Regarding the importance of population ́s quality life, both terrestrial surface temperature and vegetation presence should be considered together, since the knowledge about the possible correlation between these two variables becomes preponderant for decision towards the well-being of the population. The analysis of the scatter plot between the TST and NDVI values showed that the behavior of the trendline was best represented by a degree 3 polynomial, whose R-Squared was 0.73, indicating a high correlation between the values of TST and NDVI. In relation to the values associated with the presence of dense vegetation (NDVI greater than 0.5), characterized by areas of preserved native vegetation, such as riparian forests, parks and natural reserves, it was verified that the TST decreases according as the NDVI increases and that represents a temperature reduction of approximately 4°C
A supernumerary designer chromosome for modular in vivo pathway assembly in Saccharomyces cerevisiae

The construction of microbial cell factories for sustainable production of chemicals and pharmaceuticals requires extensive genome engineering. Using Saccharomyces cerevisiae, this study proposes Synthetic Chromosomes (SynChs) as orthogonal expression platforms for rewiring native cellular processes and implementing new functionalities. Capitalizing the powerful homologous recombination capability of S. cerevisiae, modular SynChs of 50 and 100 Kb were fully assembled de novo from up to 44 transcriptional-unit-sized fragments in a single transformation. These assemblies were remarkably efficient and faithful to their in silico design. SynChs made of non-coding DNA were stably replicated and segregated irrespective of their size without affecting the physiology of their host. These non-coding SynChs were successfully used as landing pad and as exclusive expression platform for the essential glycolytic pathway. This work pushes the limit of DNA assembly in S. cerevisiae and paves the way for de novo designer chromosomes as modular genome engineering platforms in S. cerevisiae.
Coexistence of neuroendocrinal rectal tumour and pulmonary tuberculosis – diagnostic difficulties

W ostatniej dekadzie guzy neuroendokrynne układu pokarmowego (ang. gastroenteropancreatic neuroendocrinal tumors – GEP NET) budzą ogromne zainteresowanie ze względu na postęp związany z ich rozpoznawaniem i leczeniem. Stanowią one niejednorodną grupę nowotworów wywodzących się z gruczołów wydzielania wewnętrznego, wysp komórek endokrynnych tkanek gruczołowych oraz układu rozproszonych komórek endokrynnych (ang. diffuse endocrine system – DES). Zapadalność na GEP NET wynosi 10–13 przypadków na 1 mln mieszkańców rocznie. Przyjmuje się, że guzy te stanowią ok. 2% wszystkich nowotworów układu pokarmowego i 60% wszystkich guzów typu NET [1–3]. Guzy typu GEP NET długo mogą nie dawać żadnych dolegliwości lub ich objawy kliniczne mogą nie być charakterystyczne. W przypadku nowotworów czynnych wydzielniczo objawy choroby mogą zależeć od aktywności wydzielanej substancji. Diagnostyka GEP NET opiera się na oznaczaniu specyficznych i niespecyficznych markerów, połączeniu nowoczesnych badań obrazowych ze scyntygrafią z użyciem znakowanych izotopem analogów somatostatyny (ang. somatostatin receptor scyntigraphy – SRS) oraz badaniach histopatologicznych i immunohistochemicznych [4, 5]. Guzy neuroendokrynne układu pokarmowego odbytnicy stanowią 17% przypadków rakowiaków w przewodzie pokarmowym [6]. Najczęściej rozpoznawane są przypadkowo przy okazji badania endoskopowego wykonywanego z innych przyczyn lub w trakcie badań przesiewowych w kierunku raka jelita grubego. Stwierdzane są raz na 1000–2000 badań. Większość pacjentów nie ma objawów. Duże guzy manifestują się tak samo jak rak odbytnicy [7]. W pracy przedstawiono bardzo rzadki przypadek współwystępowania wysoko dojrzałego raka neuroendokrynnego odbytnicy i gruźlicy płuc oraz związane z tym trudności diagnostyczne.
Characterization of the Global Sources of Atmospheric Ammonia from Agricultural Soils

Global ammonia (NH3) emissions to the atmosphere are projected to increase in the coming years with the increased use of synthetic nitrogen fertilizers and cultivation of nitrogen‐fixing crops. A statistical model (NH3_STAT) is developed for characterizing atmospheric NH3 emissions from agricultural soils and compared to the performance of other global and regional NH3 models (e.g., Emission Database for Global Atmospheric Research, Magnitude and Seasonality of Agricultural Emissions, MIX, and U.S. Environmental Protection Agency). The statistical model was developed from a multiple linear regression between NH3 emission and the physicochemical variables. The model was evaluated for 2012 NH3 emissions. The results indicate that, in comparison to other data sets, the model provides a lower global NH3 estimate by 58%, (NH3_STAT: 13.9 Tg N yr−1; Emission Database for Global Atmospheric Research: 33.0 Tg N yr−1). We also performed a region‐based analysis (United States, India, and China) using the NH3_STAT model. For the United States, our model produces an estimate that is a ~1.4 times higher in comparison to the Environmental Protection Agency. Meanwhile, the NH3_STAT estimate for India shows NH3 emissions between 0.8 and 1.4 times lower when compared to other data sets. A lower estimate is also seen for China, where the model estimates NH3 emissions 0.4 to 5 times lower than other data sets. The difference in the global estimates is attributed to the lower estimates in major agricultural countries like China and India. The statistical model captures the spatial distribution of global NH3 emissions by utilizing a simplified approach compared to other readily available data sets. Moreover, the NH3_STAT model provides an opportunity to predict future NH3 emissions in a changing world.
Peer supported open dialogue in a UK NHS trust – a qualitative exploration of clients’ and network members’ experiences

As the evidence base in relation to open dialogue continues to grow and develop, this paper contributes to the growing evidence base within the UK. The purpose of this paper is to focus on the experiences of those who have received the service and reports a qualitative evaluation of an open dialogue service operating within the National Health Service of the UK. ,The opportunity to participate was offered to all those who had received open dialogue within this particular National Health Service (NHS) trust. In total, seven participants, from four different social networks, participated in the research and attended semi-structured focus groups. The audio recordings of all focus groups were transcribed and the data as subjected to inductive thematic analysis. ,The results provide an insight into the lived experience of the individuals who received open dialogue. The analysis of the data gathered in the focus groups revealed three major themes: relational mutuality, dichotomy with other mental health services and dialogical freedom. ,The results suggest that individuals and networks positively experienced receiving open dialogue, particularly in relation to the way in which they were able to relate to, and work with practitioners. However, the results did also raise some issues in relation to the complications of introducing the open dialogue model into existing NHS structures. ,This research contributes to the emerging evidence base in relation to open dialogue, especially considering the current lack of existing research undertaken within the UK.
Implementação de arquitetura baseada em IoT para leitura de tags RFID de Ultra Alta Frequência

Internet of Things comprises an increasing number of interconnected smart devices, where communication happens anytime, anywhere, reducing hardware costs and the complexity of the architectures. Reading Radio Frequency Identification tags using Ultra High Frequency is an activity that can generate a large amount of data due to the tag reader of that frequency. This work proposes an architecture that implements the reading of Radio Frequency Identification tags using Ultra High Frequency with a low cost tag reader in relation to those that use this frequency in an infrastructure with cloud computing and microservices. The use of cloud computing and microservices is necessary because of the scalability and flexibility for the large volume of data that can be generated in the reading of Radio Frequency Identification tags using Ultra High Frequency. The proposed architecture was applied in a real case study to verify their adherence and compliance, in addition to showing up properly performed the case study. The results obtained demonstrate that the tag reading board with Radio Frequency Identification chosen obtained a satisfactory performance in the reading of tags, as well as the architectural decisions proposed in the work. In scenarios where reading distance is a fundamental requirement, it is necessary to include an external antenna for better tag reading results. The use of cloud computing and microservices have been shown to have a high development cost in the proposed architecture due to its complexities and the amount of resources created to implement the architecture.