Miracle-dz/UniFAR-FTUs huggingface dataset:
Leveraging SNOMED and ICD-9 cross mapping for semantic interoperability at a RHIO

The HEAL10-NY grant, funded by the New York State Government, is an outcome of the state's effort to integrate hospitals, clinics and laboratories in New York. This paper discusses the mapping strategies adopted for the semantic and process interoperability between two hospital systems that have been implemented at two different clinical settings using standard vocabularies. All scripts EMR is being used at ante/prenatal clinics to document ante/prenatal care and General Electricity's Centricity Perinatal (CPN) is being used at labor and delivery units in the hospital. Both applications differ in their content usage, software/hardware architectures, and platforms. Clinical information from these prenatal clinics/hospitals is transmitted after every visit to the RHIO, which acts as a clinical data repository and an aggregator of clinical information. At the time of admission for labor and delivery, the aggregated data is pushed to the inpatient labor and delivery system. This paper describes the usage of the recursive functions to traverse the SNOMED hierarchies to match the granularity levels of the All scripts EMR application as well as SNOMED→ICD-9 crosswalk tables.
Chronic Alcohol Consumption Modulates the Clotting Time In Wistar Rats

The study investigated the changes in blood clotting time due to the effect of chronic consumption of alcohol. Thirty six (36) adult male Wistar rats were randomly divided into six groups of A, B, C, D, E and F (n=6). Animals in experimental groups B, C and D were given 15%, 20% and 25% alcohol respectively by oral intubation for forty two (42) days, groups E and F received 25% alcohol each and after initial treatment alcohol was withdrawn for an additional twenty one (21) and forty two (42) days respectively, while group A (control) received equivalent volume of distilled water. In all groups, the blood samples were obtained by cardiac puncture under chloroform anaesthesia to determine clotting time. The study revealed significant (p<0.05) increase in clotting time in the animals treated with alcohol while the clotting time decreased after subsequent alcohol withdrawal. Chronic of alcohol consumption therefore increases clotting time and its withdrawal returns the clotting time to normal level.
Obesity-related cardiac and vascular structural alterations: beyond blood pressure overload.

Studies performed in the past few years have convincingly documented the adverse impact the obese state carries on cardiovascular morbidity and mortality with particular reference to congestive heart failure, myocardial infarction and renal failure as well [1–3]. Data recently collected in the context of the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study have reinforced the results of the above-mentioned studies, by showing, for example, that the occurrence of an obese state is an important predictor of cardiovascular events in the general population living in northern Italy, Brianza area, even when data are adjusted for confounders such as age and clinic blood pressure values (Mancia G, Grassi G, et al., unpublished observations). Interestingly, similar conclusions can be achieved when the data are adjusted for 24-h ambulatory blood pressure values, suggesting that extrahaemodynamic factors participate at the obesity-related increase in cardiac mass. Despite the large amount of data collected in the past years, several aspects related to this issue still remain far from being fully elucidated. These include, for example, the pathophysiology of obesity-related left ventricular hypertrophy. They also include, however, other aspects such as the relative weight of haemodynamic vs. nonhaemodynamic factors in the development and progression of the cardiac structural changes; the role of neurohumoral factors in the pathophysiology of this complication; and the clinical impact of different types of cardiac structural alterations reported in the obese state.
Interventions for reducing adolescent alcohol abuse: a meta-analytic review.

OBJECTIVE To assess the effectiveness of substance abuse interventions for their ability to reduce adolescent alcohol use. DATA SOURCES MEDLINE; PsycINFO; ERIC; Wilson Social Science Abstracts; Criminal Justice Abstracts; Social Work Abstracts; Social Science Citation Index; Dissertations Abstracts International; National Criminal Justice Research Service; Social, Psychological, Criminological, Educational Trials Register; and the PsiTri databases from 1960 through 2008. STUDY SELECTION Of 64 titles and abstracts identified, 16 studies and 26 outcomes constituted the sample. The researchers calculated Hedges g effect sizes and used a random-effects model to calculate adjusted pooled effect sizes. Heterogeneity was explored using stratified analyses. Main Exposure Completion of a substance abuse intervention that aimed to reduce or eliminate alcohol consumption. MAIN OUTCOME MEASURES Abstinence, frequency of alcohol use, and quantity of alcohol use measured between 1 month and 1 year upon completion of treatment. RESULTS Pooled effects of standardized mean differences indicate that interventions significantly reduce adolescent alcohol use (Hedges g = -0.61; 95% confidence interval [CI], -0.83 to -0.40). Stratified analyses revealed larger effects for individual treatment (Hedges g = -0.75; 95% CI, -1.05 to -0.40) compared with family-based treatments (Hedges g = -0.46; 95% CI, -0.66 to -0.26). CONCLUSIONS Treatments for adolescent substance abuse appear to be effective in reducing alcohol use. Individual-only interventions had larger effect sizes than family-based interventions and effect sizes decreased as length of follow-up increased. Furthermore, behavior-oriented treatments demonstrated promise in attaining long-term effects.
Atypical Mycobacterial and Fungal Infections in Cystic Fibrosis

Nontuberculous mycobacteria (NTM) and fungi are prevalent in the sputum of cystic fibrosis patients and are increasingly recognized to cause clinically significant disease. In both instances the organisms are ubiquitous within the environment making exposure common, although specific risk factors that contribute to active pulmonary infection have not been identified. A consistent and aggressive approach to screening for NTM and fungi within the cystic fibrosis airway is likely indicated, especially in the setting of clinical deterioration despite standard antipseudomonal therapies.
Specific Bradycardic Agents, A New Therapeutic Modality for Anesthesiology: Hemodynamic Effects of UL‐FS 49 and Propranolol in Conscious and Isoflurane‐anesthetized Dogs

A “specific bradycardic agent” has direct negative chronotropic actions without producing other systemic or coronary hemodynamic alterations. UL-FS 49, a recently synthesized structural analog of verapamil without classical slow channel calcium blocking activity, is proposed as such an agent. The purpose of this investigation was to characterize the hemodynamic and electrocardiographic actions of UL-FS 49 (0.25, 0.50, and 1.0 mg/kg) and compare its effects with those of propranolol (0.25, 0.50, and 1.0 mg/kg) in conscious or isoflurane-anesthetized (with and without neuro-muscular blockade by pancuronium) chronically instrumented dogs. In six groups, comprising 52 experiments, UL-FS 49 was found to be more efficacious than propranolol in reducing heart rate, although this agent did not block the hemodynamic response to isoproterenol. UL-FS 49 produced 45–50% reductions in heart rate in dogs with isoflurane-induced tachycardia as compared to 15 and 30% reductions following propranolol. Furthermore, few other he modynamic alterations were produced by UL-FS 49 indicating the remarkable specificity of this drug for reducing heart rate. A “specific bradycardic agent” such as UL-FS 49 may be useful clinically during the perioperative period. Such a drug may be especially advantageous for patients with documented or suspected ischemic heart disease, those who cannot tolerate the side effects of beta adrenergic blockade, as well as patients requiring a greater reduction in heart rate than can be obtained with beta adrenergic receptor antagonists.
Endothelial injury in human atherosclerosis.

A light and electron microscopic investigation (scanning and transmission electron microscopy) was performed on 51 human atherosclerotic carotid lesions. The purpose of this study was to establish whether features of endothelial injury such as those described in animals occur in man and whether these features can be related to specific stages of human atherosclerosis. Irrespective of their histological appearance the atherosclerotic lesions were covered with endothelium which showed non-specific changes in cell shape and size. However, all complicated lesions appeared denuded. Moreover, a peculiar interaction of endothelium with monocytes and lymphocytes as well as blood components (e.g., fibrin and lipoproteins) was observed in intimal thickenings, fatty streaks and uncomplicated plaques. The surface exposure of macrophage-derived foam cells was seen on florid fatty lesions. Large areas of the arterial surface lacking any endothelial coverage were characteristic of complicated plaques. They appeared to be a consequence of the arterial wall degeneration with an associated failure in endothelial repair.
Functional interaction of TRPV4 channel protein with annexin A2 in DRG

Abstract Background: Transient receptor potential vanilloid 4 (TRPV4) is a Ca2+-permeable, non-selective cation channel that is involved in the transmission of pain signals mediated by dorsal root ganglion (DRG). Annexin A2 belongs to a class of membrane-binding proteins that plays an important role in the regulation of ion channels. Nevertheless, little is known about the interaction between them in DRG. In this paper, we evaluated the functional interaction of TRPV4 with annexin A2 in DRG. Methods: We have used immunocytochemistry and co-immunoprecipitation assays to investigate the interaction between annexin A2 and TRPV4 in DRG. The role of annexin A2 in the regulation of TRPV4 activity in DRG was further verified by measurement of intracellular free calcium concentrations ([Ca2+]i) and substance P (SP) release. Results: First, annexin A2 was showed partial co-localization with TRPV4 in DRG neurons. Then, annexin A2 and TRPV4 were co-precipitated with each other in DRG lysates. Furthermore, the downregulation of annexin A2 using specific small interfering RNA significantly inhibited Ca2+ influx and SP mediated by TRPV4. Conclusion: Our results provide evidence that annexin A2 is associated with TRPV4 and regulates TRPV4-mediated Ca2+ influx and SP release in DRG neurons. The objective of this work is to determine the influence of annexin A2 on TRPV4 in DRG neurons, which may be the basis for treatment of pain relief.
Recognizing and managing comorbidities in psoriatic arthritis

Purpose of reviewMany patients with psoriatic arthritis (PsA) have additional medical problems that can have an impact on morbidity and mortality. The goal of this review is to summarize the available evidence to date on the association of medical comorbidities with PsA and the implications these comorbidities have on prognosis, therapy selection and treatment response. Recent findingsCardiovascular disease, metabolic syndrome, obesity, diabetes, fatty liver disease Crohn's disease, ophthalmic disease, depression and anxiety are common comorbidities associated with PsA. Additional comorbidities may include an elevated risk for malignancy and osteoporosis; however, fewer studies have addressed these issues and the data available are sometimes conflicting. SummaryAll clinicians caring for patients with PsA should be aware of the relevant comorbidities affecting patients with PsA and should have an understanding of how these comorbidities affect management.
Anticipation Induces Polarized Collective Motion in Attraction Based Models

In most models of collective motion in animal groups each individual updates its heading based on the current positions and headings of its neighbors. Several authors have investigated the effects of including anticipation into models of this type, and have found that anticipation inhibits polarized collective motion in alignment based models and promotes milling and swarming in the one attraction-repulsion model studied. However, it was recently reported that polarized collective motion does emerge in an alignment based asynchronous lattice model with mutual anticipation. To our knowledge this is the only reported case where polarized collective motion has been observed in a model with anticipation. Here we show that including anticipation induces polarized collective motion in a synchronous, off lattice, attraction based model. This establishes that neither asynchrony, mutual anticipation nor motion restricted to a lattice environment are strict requirements for anticipation to promote polarized collective motion. In addition, unlike alignment based models the attraction based model used here does not produce any type of polarized collective motion in the absence of anticipation. Here anticipation is a direct polarization inducing mechanism. We believe that utilizing anticipation instead of frequently used alternatives such as explicit alignment terms, asynchronous updates and asymmetric interactions to generate polarized collective motion may be advantageous in some cases.
Advanced Smart Mobile Monitoring Solution for Managing Efficiently Gas Facilities of Korea

Remote monitoring and control system using Wireless communication have been developed to improve the efficiency of management solution for industrial facilities. However, those systems might be decreasing the efficiency and convenience because of connecting portable device using wired cable (RS232C or USB). This study is intended to design and develop a mobile smart city gas safety management system in order to solve inefficiency and inconvenience of wireless smart city gas safety management system. The mobile system is to be designed to be applicable to major city gas supply facilities and to provide augmented reality-based facility information in order to improve usability and practicality. Accordingly, this system is being implemented to be usable on diverse smart devices and is expected to bring about management efficiency with its strength and mobility.
No difference in patient satisfaction or quality of care provided by nurses or GPs for low-complexity primary care presentations

Commentary on: Iglesias B, Ramos F, Serrano B, et al. A randomised controlled trial of nurses vs. doctors in the resolution of acute disease of low complexity in primary care. J Adv Nurs 2013;69:2446–57. [OpenUrl][1][CrossRef][2][PubMed][3] As the prevalence of chronic disease increases, both due to an ageing population and more efficient treatment and monitoring of patients with chronic diseases, GPs are experiencing an increased demand for health services.1 ,2 At the same time, an increasing demand exists for high-quality services in the form of same-day consultations.3 This … [1]: {openurl}? query=rft.jtitle%253DJ%2BAdv%2BNurs%26rft.volume%253D69%26rft.spage%253D2446%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fjan.12120%26rft_id%253Dinfo%253Apmid%252F23517494%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref? access_num=10.1111/jan.12120&link_type=DOI [3]: /lookup/external-ref? access_num=23517494&link_type=MED&atom=%2Febnurs%2F17%2F4%2F119.atom
Medical Encounters in Finnish Reception Centres: Asylum-Seeker and Clinician Perspectives

Refugee health often is shaped by interactions with clinicians in care settings that lack ethnocultural match. The article analyses intersubjective perspectives concerning key aspects of 41 ethnoculturally discordant medical encounters involving asylum seekers, mainly from the former Soviet Union, the former Yugoslavia, Kurdish areas in the Middle East, and Somalia, resident during summer 2002 in five Finnish reception centres. Attaining congruent perspectives is an important challenge in transnational encounters involving clinicians and displaced persons. The healthcare perspectives of asylum seekers and their attending Finnish physicians showed little correspondence. Transnational competence (TC) offers an innovative comprehensive framework for assessing and addressing ethnoculturally discordant healthcare encounters. In this study, we most frequently encountered congruent perspectives regarding health status at the time of arrival, illness explanations, utilization of ethnocultural healthcare practices, and perceptions regarding the presence of mental health problems, depression, and place-of-origin contributors among patients attended by high-TC physicians. The findings also suggest that the TC of all medical-encounter participants makes a difference in terms of asylum seekers’ satisfaction with medical encounters, confidence in the future value of the attending physician’s recommendations, and perceived healthcare effectiveness in their new surroundings—perspectives with the potential to exert a positive impact on health outcomes for forced migrants and receiving societies.
Strong Stabilization of a Non-uniform SCOLE Model

Abstract The SCOLE (NASA Spacecraft Control Laboratory Experiment) model is considered the best model for the coupled system consisting of a flexible beam with one end clamped and the other end linked to a rigid body. This model has been studied extensively, with most papers assuming that the flexible beam is uniform. In our study we allow the coefficients of the beam equation to vary with position, like in Guo [2002] which has considered the non-homogeneous structure of the beam. It has been proved that the exponential stabilization of the uniform SCOLE model is impossible to achieve by boundary feedback from the natural output signals (the speed and the angular velocity of the rigid body) (see Rao [1995]). Thus the non-uniform SCOLE model is not exponentially stabilizable in general, by using these signals. Although the exponential stabilization of the SCOLE model can be obtained by high order output feedback (see Guo [2002] and Rao [1995]), the corresponding closed-loop system is not well-posed. In addition, such a feedback is difficult to realize in practice. Thus we have to compromise for strong stabilization. Following a recent strong stabilization theorem for passive systems in Curtain and Weiss [2007], we have shown that the non-uniform SCOLE model is strongly stabilizable by static output feedback from either the speed or the angular velocity of the rigid body.
Performance measures for niching algorithms

Numerous niching algorithms have been developed to find multiple optima for multimodal optimisation problems. Analysis of niching algorithms presents a problem due to the multiple objectives of niching algorithms, that is, to find as many optima as possible, to find accurate solutions, and to find a diverse set of solutions. Performance analysis becomes more difficult when no knowledge of the fitness landscape is available. This is due to the assumption of most performance measures that information about the optima is available. This paper provides a critical review of existing performance measures for niching algorithms. In addition, the paper introduces a new approach, the mid-point technique, to determine a unique set of solutions for performance measurement. The performance measures are used to evaluate the performance of seven particle swarm optimisation niching algorithms. The obtained results are then used to compute the predictive capability of non-knowledge assuming performance measures to that of knowledge assuming measures. The analysis shows that the considered performance measures do show a convergent behaviour.
Inflammatory cells, refractive regression, and haze after excimer laser PRK.

OBJECTIVE To examine the role of inflammatory cell invasion and aspects of tissue reaction on refractive regression and corneal haze after myopic PRK in rabbits. METHODS Measurements were made for 12 weeks postoperatively of haze intensity, corneal topography, tear cytology, inflammatory cell invasion, subepithelial fibroblast density, and the thickness of the newly laid down connective tissue and of the regrown epithelium. RESULTS Inflammatory cell invasion could be prevented by fitting a soft contact lens, but this had no effect on the haze or the regression. Haze intensity correlated with subepithelial fibroblast proliferation but not with new connective tissue formation or epithelial hyperplasia. Neither connective tissue nor epithelium regrew in the form of a lens and thus they could not account for regression. Intensive treatment with corticosteroids resulted in a marked reduction in postoperative haze and a slight lessening of long-term regression. Correspondingly, it reduced fibroblast proliferation. CONCLUSIONS Haze appears, at least in part, to be a result of fibroblast proliferation. Regression is possibly caused by slow distortion of existing tissue rather than the growth of new.
Visual Requirements for Safety and Mobility of Older Drivers

Efforts to assess visual deterioration with increasing age, coupled with new mechanisms proposed to limit the exposure of visually impaired drivers to driving risks, have emerged in response to the increase in older drivers. Visual functions discussed in this context include static acuity (photopic, mesopic, and in the presence of glare), dynamic visual acuity, visual field, contrast sensitivity, and motion perception. Exposure control mechanisms discussed include alternative periodic vision testing strategies, visual training, and environmental and vehicular modifications to accommodate the older driver. Finally, relevant research needs are addressed.
Methicillin-Resistant Staphylococcus aureus Harboring mecC in Livestock in Spain

ABSTRACT We report for the first time mecC-positive methicillin-resistant Staphylococcus aureus (mecC-MRSA) in livestock in Spain. One isolate (sequence type 130) was found in milk samples among 601 S. aureus isolates obtained from 229 dairy sheep farms. This finding highlights the potential for zoonotic transmission of mecC-positive MRSA and the need for surveillance programs to monitor its presence and clonal evolution.
Transport of vitamin B12 in Escherichia coli: cloning of the btuCD region

The transport of vitamin B12 in Escherichia coli requires a specific vitamin B12 receptor protein in the outer membrane and the tonB gene product. In addition, the btuC gene, located at min 38 on the genetic map, has been found to influence vitamin B12 uptake or utilization. The btuC function is required for the growth response to vitamin B12 when the outer membrane transport process (btuB or tonB function) is defective. However, even in a wild-type strain, btuC is required for proper transport of vitamin B12. Additional mutations in the vicinity of btuC were isolated as lac fusions that produced a phenotype similar to that of a btuC mutant. The btuC region was cloned by selection for complementation of a btuC mutation. Complementation testing with plasmids carrying various deletions or transposon Tn1000 insertions demonstrated that the new mutations defined a separate, independently expressed locus, termed btuD. The coding regions for both genes were identified on a 3.4-kilobase HindIII-HincII fragment and were 800 to 1,000 base pairs in length. They were separated by a 600- to 800-base-pair region. The gene order in this portion of the chromosome map was found to be pps-zdh-3::Tn10-btuD-btuC-pheS. Expression of beta-galactosidase in the btuD-lac fusion-bearing strains, whether proficient or defective in vitamin B12 transport, was not regulated by the presence of vitamin B12 in the growth medium.