Miracle-dz/UniFAR-FTUs huggingface dataset:
Blood Parameters as Surrogate Markers to Predict Treatment Response after Radiation Therapy in Head and Neck Malignancies

Background : Several prognostic factors have been defined for Head and neck cancers that can influence response to therapy and eventual outcomes. Recent studies show that Neutrophil to Lymphocyte ratio (NLR) Platelet to Lymphocyte ratio (PLR) and Red blood cell distribution width (RDW)are hematologic makers that have started to show prognostic significance across many types of cancers. Aim: Evaluate role of NLR, PLR and RDW as surrogate markers to predict treatment response in head and neck malignancies Methodology: We retrospectively analysed stage II to IVB HNC treated with radical intent from Jan 2018 to Dec 2018 in the department of Radiation oncology. Inclusion criteria were new histologically confirmed head and necksquamous cell cancer. Result: Out of 51patients analysed, 31 patients had complete response and 19 had residual/recurrence. Baseline RDW NLR and PLR ranged from10.2-20.1, 1.02-18.6 and 22.7-608.9 respectively. In complete response patients mean NLR was 2.0 (CI-1.78-2.21) which was significantly lower than mean NLR in disease which was 5.18 (CI-3.46-6.90). Mean PLR in complete response patients was 93.99 (CI-79.11-108.87) that was significantly lower than mean PLR in disease which was 218.47 (CI-158.59-278.35). There was a significantly higher RDW in disease patients with mean 16.0 (CI-15.13-16.87) than mean RDW in complete response patients which was 13.52 (CI-12.93-14.88). Conclusion: NLR and PLR represent immunity status and also an indicator of prognosis of cancer patients. RDW is a marker of systemic inflammatory response. In our study elevated pre-treatment NLR, PLR and RDW predicted poor response to treatment.
Evaluation of the tumor-targeting efficiency and intratumor heterogeneity of anticancer drugs using quantitative mass spectrometry imaging

The development of improved or targeted drugs that discriminate between normal and tumor tissues is the key therapeutic issue in cancer research. However, the development of an analytical method with a high accuracy and sensitivity to achieve quantitative assessment of the tumor targeting of anticancer drugs and even intratumor heterogeneous distribution of these drugs at the early stages of drug research and development is a major challenge. Mass spectrometry imaging is a label-free molecular imaging technique that provides spatial-temporal information on the distribution of drugs and metabolites in organisms, and its application in the field of pharmaceutical development is rapidly increasing. Methods: The study presented here accurately quantified the distribution of paclitaxel (PTX) and its prodrug (PTX-R) in whole-body animal sections based on the virtual calibration quantitative mass spectrometry imaging (VC-QMSI) method, which is label-free and does not require internal standards, and then applied this technique to evaluate the tumor targeting efficiency in three treatment groups—the PTX-injection treatment group, PTX-liposome treatment group and PTX-R treatment group—in nude mice bearing subcutaneous A549 xenograft tumors. Results: These results indicated that PTX was widely distributed in multiple organs throughout the dosed body in the PTX-injection group and the PTX-liposome group. Notably, in the PTX-R group, both the prodrug and metabolized PTX were mainly distributed in the tumor tissue, and this group showed a significant difference compared with the PTX-liposome group, the relative targeting efficiency of PTX-R group was increased approximately 50-fold, leading to substantially decreased systemic toxicities. In addition, PTX-R showed a significant and specific accumulation in the poorly differentiated intratumor area and necrotic area. Conclusion: This method was demonstrated to be a reliable, feasible and easy-to-implement strategy to quantitatively map the absorption, distribution, metabolism and excretion (ADME) of a drug in the whole-body and tissue microregions and could therefore evaluate the tumor-targeting efficiency of anticancer drugs to predict drug efficacy and safety and provide key insights into drug disposition and mechanisms of action and resistance. Thus, this strategy could significantly facilitate the design and optimization of drugs at the early stage of drug research and development.
Klberhasilan dalam kompetisi suatu bangsa ditentukan oleh kemampuan penguasaan ilmu dan teknologi dan arakteristik-karakteristik lain yang diperlukan dalam ber- saing untuk mendapatkan peluang berkiprah. Pendidikan memiliki tugas untuk menempa anak didik agar memiliki kompetensi tekno- logis dan kom

The system employing semester credit units requires students' good self-regulated learning in order that they attain learning goals successfully. The present article concerns a research aimed at knowing (1) of what level mechanical engineering students' selfdependence in learning was as seen from both their self-stated views about their self-regulated learning and their self-regulated learning in practice; (2) whether there was any difference in level of selfregulated learning among those having different types of high school educational background; (3) whether there was any difference in level of self-regulated learning among those having studied for different numbers of semesters; and (4) whether the environment where they live influences their self-dependence in learning, or, in other words, their self-regulated learning. The research employed a positivistic approach which was exploratory in nature. The population consisted of 254 students of the Mechanical Engineering Education Study Program, Faculty of Engineering, State University of Yogyakarta, who were taking courses in one even-numbered semester or another in the academic year of 200512006. The sample size was 228 and the research subjects were randomly selected. The data were compiled by using a closed self-report type of questionnaire using a Linkert-type scale model. The data were analyzed by means of non-parametric statistics using the Kruskal-Wallis Test and the Mann-Whitney U Test since the data distribution did not fulfill the inferential parametric analysis assumption.
Comparative prognostic implication of treatment response assessments in mCRPC: PERCIST 1.0, RECIST 1.1, and PSA response criteria

Accurate appraisal of treatment response in metastatic castrate-resistant prostate cancer (mCRPC) is challenging in view of remarkable tumor heterogeneity and the available choices among many established and novel therapeutic approaches. The purpose of this single-center prospective study was to evaluate the comparative prognostic utility of PERCIST 1.0 in predicting overall survival (OS) in patients with mCRPC compared to RECIST 1.1 and prostate-specific antigen (PSA)-based treatment response assessments. Methods: Patients with mCRPC were prospectively enrolled if they were beginning systemic medical therapy or transitioning to new systemic therapy after not responding to a prior treatment. All patients underwent a baseline 18F-fluorodeoxyglucose (FDG) positron emission tomography/ computed tomography (PET/CT) prior to the initiation of treatment and again 4 months after the start of therapy. Patients' responses to treatment at 4 months compared to baseline were evaluated with RECIST 1.1, PERCIST 1.0 and PSA response criteria. The associations between patients' response categories and OS were evaluated. OS was defined as the duration in time between the date of baseline PET/CT to death from any cause. Patients with different response status were compared with logrank tests. Survival probabilities were calculated using the Kaplan-Meier method. Results: Patients with progressive disease by PSA response criteria at 4 months demonstrated significantly shorter OS (24-month OS probability: 18% ± 11%) compared to patients with stable disease, SD, (44% ± 19%, p=0.03) and complete response, CR, or partial response, PR, (53% ± 11%, p=0.03). RECIST 1.1 response criteria demonstrated a similar trend in OS, however no statistically significant differences were noted between patients with PD (25% ± 15%) compared to SD/non-CR, non-PD (54% ± 13%) and CR/PR (54% ± 14%) (p=0.13). PERCIST 1.0 criteria demonstrated significant differences in OS between responders, CMR/PMR (56% ± 12%), compared to SMD (38% ± 17%, p=0.03) and PMD (21% ± 10%, p=0.01). Patients with progressive disease by both PERICST 1.0 and PSA response criteria demonstrated significantly worse OS (24-month OS: 0%, 12-month OS: 31% ± 14%) compared to patients with progressive disease by either response criteria. Conclusion: PERCIST 1.0 may provide significant prognostic information for patients with mCRPC undergoing systemic chemotherapy, particularly when incorporated with PSA treatment response criteria.
EXACT CONTROLLABILITY FOR THE WAVE PROBLEM WITH ROBIN CONDITIONS ON AN ε- PERIODIC DOMAIN M. Dumitrache and C. Gheldiu

The paper presents the study of the exact controllability on an εperiodic domain lying along two directions. The exact control is applied on a part of the boundary domain, in the case of the wave problem with Robin conditions. The result is a plane wave problem, with convection term end exactly controlled by a control which represents a combination between the limit of the initial control and the convection of the limit. 2010 Mathematics Subject Classification: 35B27, 76M50.
Supplementary material to "A Global Analysis of Dust Diurnal Variability Using CATS Observations"

Abstract. The current study investigates the diurnal cycle of dust loading across the global tropics, sub-tropics, and mid-latitudes by analyzing aerosol extinction and typing profiles observed by the Cloud–Aerosol Transport System (CATS) lidar aboard the International Space Station. According to the comparison with ground-based and other satellite observations, CATS aerosol and dust loading observations exhibits reasonable quality but significant day–night inconsistency. To account for this day–night inconsistency in CATS data quality, the diurnal variability in dust characteristics are currently examined separately for daytime and nighttime periods. Based on an analysis of variance analytical framework, pronounced diurnal variations in dust loading are generally uncovered during daytime periods and over terrestrial areas. The current study identifies statistically significant diurnal variability in dust loading over key dust sources, including the Bodélé Depression, the West African El Djouf, Rub-al Khali Desert, and western and southern North America, confirming the previous observation-based findings regarding the diurnal cycle of dust emission and underlying meteorological processes in these regions. Significant seasonal dust diurnal variability is identified over the Iraqi and Thar deserts. The identified significant diurnal cycles in dust loading over the rainforests in Amazon and tropical southern Africa are hypothesized to be driven by enhanced dust emission due to wildfires.
UTILIZATION OF ENERGETIC GRASS FIBRE FOR MODIFICATION OF RECOVERED FIBRE PROPERTIES

Innovation trends in paper industry reveal some new possibilities of novel raw materials utilization in paper production. Over the last couple of years, the energetic grass (ET) for modification of primary fibres was used. Handsheets were produced by combining ET and recovered fibres from old corrugated containers (OCC). Twelve physical or mechanical properties of prepared handsheets at different ratio of raw materials were determined. The modified content of ET in the mixed handsheets made of OCC and ET had no significant influence on thickness (maximum of thickness, 141 μm at the ratio of OCC : ET = 20 : 80). Decreasing of ET content caused increasing of physical or mechanical properties of mixed handsheets in case of four physical or mechanical properties (tear strength, tear index, air permeation resistance of paper, smoothness). However, increasing of ET content caused increasing of physical or mechanical properties in most cases.
Oligometastatic disease in prostate cancer, a continuously changing paradigm: patient selection and treatment strategy

The recent publication of the results of a relatively large cohort of patients treated with stereotactic body radiation therapy (SBRT) at the Mayo Clinic for oligometastatic prostate cancer (1) has to be considered as another significant step toward the assessment of the potential of radiation therapy in the optimal management of these “niche” patients.
O uso do bolus na radioterapia

Preliminary to the radiation therapy, it is posisble to develop a therapeutic device contained in the buccomaxillofacial prosthesis resources, creating the bolus. Bolus are materials used to increase the dose on the entrance surface of a field or to compensate for a lack of tissue. The requirements for a material to be used as a bolus include to interact with ionizing radiations in a similar manner to tissues and to be soft enough to allow its molding to the patient’s contour. There are various materials available for this purpose, however, with a relatively high cost. Some inexpensive options can also be used, such as pressed cellophane and wet gauze, however, these materials do not present favorable malleability and do not offer true reproducibility. The aim of this article was to ascertain whether there is harmonious knowledge of this technique by dental surgeons, medical oncologists and radiotherapists. This technique or device minimizes the deleterious effects resulting from exposure to radiation. It was concluded the bolus can reduce possible complications arising from radiation therapy, concomitantly offering improved living conditions during treatment.
Sugary beverages consumption and latent autoimmune diabetes in adults: systematic review and meta-analysis

Introduction. Sugary beverages consumption (SBC) has amplified globally. SBC is associated with and leads to obesity and chronic diseases, nonetheless the role of SBC in development of autoimmune disorders such as latent autoimmune diabetes in adults (LADA) has not been addressed adequately among the different ethnic groups. We conducted this meta-analysis to compare the random effect of SBC intake on the risk of development of LADA. Methods. We scrutinized the MEDLINE database up until January 2019 for articles addressing the associa­tion between sugary beverages, coffee consumption and LADA. We found 6 studies all of them addressed the LADA. We have included them in the meta-analysis and compared the random effect of SBC from the uppermost to the lowermost quantiles parallel to the risk of LADA. Results. According to the research conducted, and data extracted, which involved 15027 contributors and 1862 patients with LADA, the participants in the uppermost quantile of SBC intake (used 1–2 servings per day in most cases) were at risk of developing LADA more than those in the lowermost quantile (≤ 1 serving per month) (odds ratio [OR] 1.37 [95% CI 1.23–1.52]). Conclusion. According to the meta-analysis results excessive SBC intake may increase the risk of develop­ment of latent autoimmune diabetes in adults. However, no definite conclusions could be drawn due to heterogeneous data from low quality researches and the analysis was based on observational and case-control studies only.
Interoceptive Attention Tendencies Predict Trait Anxiety in Undergraduate Students and Hospital Nurses Participating in Stress Management Programs

Interoceptive attention tendencies have been posited as the dimensions of change in body awareness gained through the acquisition of self-regulatory skills from engaging in contemplative and body-mind health practices such as mindfulness meditation, yoga, and relaxation training. However, eff orts are still needed to confi rm the model of the dimensions and to delineate the “positive” (adaptive) and “negative” (maladaptive) forms of attention to the body due to their relationships with anxiety. This study tests the factor and predictive incremental validity assumptions of positive body awareness through correlational and regression analysis of interoceptive attention tendencies measured by the Multidimensional Assessment of Interoceptive Awareness (MAIA) with trait anxiety as the response variable measured by the State-Trait Anxiety Inventory (STAI). Data were analyzed from one-hundred and sixty-nine undergraduate students (n = 169; M age = 19.07, SD = 0.73) and sixty-six early-career nurses (n = 66, M age = 25.68, SD = 3.01) participating in stress management programs in southwestern Japan. Negative correlations between trait anxiety and the MAIA dimensions suggested divergent validity in both samples in line with previous studies, except for Noticing. Providing evidence that contrasts with other work on the instrument in Japan, Self-Regulation was found to negatively correlate with and predict trait anxiety with regressions that were consistent in direction with the original MAIA validation for both samples. Among hospital nurses, the regression coefficient for Body Listening was consistent in direction but shown to differ in magnitude from the original validation. Implications for these relationships as they relate to research on the MAIA are discussed.
Do primary care physicians use the 5As in counselling obese patients? A qualitative study

Background: Obesity is a global public health problem. A systematic review showed that intensive behavioural counselling is effective in weight management amongst patients with obesity, but little is known if primary care physicians (PCPs) are involved in delivering such counselling. Studies revealed that patients had weight reduction if they were counselled by PCPs who used the 5As (Ask, Assess, Advise, Agree and Assist) method, but PCPs varied in their use of this tool. We aimed to explore the local PCP modalities of obesity counselling and if their approaches and methods corresponded to the 5As tool. Methods: Qualitative data were obtained from interviews with 50 PCPs from public and private primary care practices during six focus group discussions and seven in-depth interviews. The interviews were audio-recorded, transcribed, audited and analysed iteratively based on the grounded theory. Emergent themes were first externally validated, and then finalized after rounds of deliberations amongst the investigators. Results: PCPs varied in their approach in obesity counselling, focusing predominantly on “Ask”, “Assess” and “Advise” in the 5As tool. “Asking” was indirect and “Assessment” rarely covered the effects of obesity on psychosocial functioning. Dietary and lifestyle modifications were the main foci in “Advise”. “Agree” was least performed. Polyclinic doctors tended to “Assist” patients with referral to other healthcare workers for further weight management, but few deliberately “Arrange” to review progress in weight management, citing barriers. Conclusion: PCPs varied in their method of obesity counselling, pending on context and setting of their practices. In contrast to “Ask’, “Assess” and “Advise”, the use of “Agree” and “Arrange” was uncommon.
Instructional Leadership Sensemaking for Science and Maths in South African Multi-Deprived Middle Schools.

Sensemaking is pivotal in shaping organisational activities, such as instructional leadership actions in schools. This study used sensemaking to explore the outcome when two middle schools with similar multi-deprivation settings followed different instructional leadership enactment trajectories for science and mathematics. Two schools with effective and ineffective instructional leadership enactment strategies respectively were purposively selected from the same locality to participate in the study. Data were obtained through semi-structured interviews with 10 participants, as well as unstructured observations. Emerging data were analysed for content by means of the technique of constant comparison. The findings of the study indicate that, although multi-deprivation conditions have the potential to shape instructional leadership, schools can use sensemaking to forge unique practices that culminate in effective instructional leadership. Since ineffective sensemaking of instructional leadership generally characterises schools in multi-deprived settings, the findings of this study make it essential for districts to provide tools that support schools’ effective sensemaking of instructional leadership.
Mapping of the Akt and Beta-arrestin Interface for Drug Development

G-protein-coupled receptors (GPCRs) are well-known therapeutic targets, and it has been demonstrated that they can signal both via guanine nucleotide-binding proteins (G proteins) signaling and arrestin signaling. Dopamine (DA) and dopamine receptors, which are GPCRs, are involved in numerous neuropsychiatric disorders. Notably, dopamine D2 receptor (D2R) signaling is targeted by drugs used for mental illnesses like bipolar disorder (BP) and schizophrenia (SZ). Indeed, a signaling pathway involving arrestin signaling is targeted by both lithium and antipsychotic medications. This pathway involves a modulation of glycogen synthase kinase 3 (GSK-3) by D2Rs via a complex formed of Akt (also called protein kinase B or PKB), β-arrestin 2 (βArr2) and protein phosphatase 2A (PP2A). The aim of this project is to further elucidate this signaling pathway by studying the direct interaction between two of its components, the proteins Akt and βArr2, in view of possible drug development.
Hemostatic materials in non-variceal upper gastrointestinal hemorrhage

Division of Gastroenterology, Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea Utah-Inha DDS and Advanced Therapeutics Research Center, Incheon, Korea Received August 5, 2019; Revised January 20, 2020; Accepted January 20, 2020 * Corresponding author. Division of Gastroenterology, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, 27 Inhang-ro, Jung-gu, Incheon 22332, Korea. E-mail address: LDH@inha.ac. kr (D.H. Lee).
Analysis of Hybrid Cryptosystem Developed Using Blowfish and ECC with Different Key Size

Hybridization is always done in search of better system which may not be always achieved. But most of the time hybridization has proved to produce a system with advantages of the algorithms used in developing that hybrid system. Even if the system doesn’t have performance enhancement it will act as multi-layer security. Here, combing of Blowfish algorithm along with ECC algorithm is performed. After hybridization their performance analysis is done based on five different parameters with different key size of Blowfish algorithm i.e. 32 bit, 128 bit, 192 bit, 256 bit, 448 bit. Among these different hybrid cryptosystem we found that the Blowfish ECC system with key size 448 bit has better performance than all other bit size.
Design of FIR Filter Using Particle Swarm Optimization

: This paper presents an optimal design of digital low pass finite impulse response (FIR) filter using Particle Swarm Optimization (PSO). The design target of FIR filter is to approximate the ideal filters on the request of a given designing specifications. The traditional based optimization techniques are not efficient for digital filter design. The filter specification to be realized PSO algorithm generatesthe best coefficients and try to meet the ideal frequency response. Particle swarm optimization (PSO) proposes a new equation for the velocity vector and updating the particle vectors and hence the solution quality is improved. The PSO technique enhances its search capability that leads to a higher probability of obtaining the optimal solution. In this paper for the given problem the realization of the FIR filter has been performed. The simulation results have been performed by using the particle swarm optimization (PSO) method.