Miracle-dz/UniFAR-FTUs huggingface dataset:
Similarity threshold to detect plagiarism in Spanish

Plagiarism is, unfortunately, a very common practice in today's society. This practice occurs in several areas: journalistic, educational, literary and scientific world, among others. Previous studies on the detection of plagiarism establish that it is unlikely that two authors write independently two identical sequences of more than seven words in English. This article examines whether this established similarity threshold in English can be applied into the Spanish language. In addition, the possible variability in the threshold according to the text genre in which the sequence has occurred been also taken into account in this study. For this reason, a selection of utterances in Spanish, from different genres (journalism, literary and scientific) has been analysed. Results show that the similarity threshold for the Spanish language is lower than for the English language regardless of genre. Findings of this study will contribute to furnish more reliable results in Court, in cases of plagiarism detection.
Natural Triterpenoids for the Treatment of Diabetes Mellitus: A Review

Triterpenoids, an important group of secondary metabolites, are widely distributed in nature. Many triterpenoids have been found with potential therapeutic effect against diabetes mellitus. However, the use of triterpenoids for the treatment of diabetes has not been systematically discussed previously. This review summarized the anti-diabetic activity of natural triterpenoids reported since the late 1980s with the emphasis on the molecular mechanisms.
The Triumphs of Joseph: How Today's Community Healers are Reviving our Streets and Neighborhoods

Listening to Joseph is a tribute to a contemporary miracle -- workers of the inner city who exemplify the imagination, courage, and the self-help ethic necessary to renew our communities. As the biblical story goes, Joseph was imprisoned by the Pharaoh, but when the ruler had a nightmare he and his soothsayers could not understand, it was the young man from the dungeon who was able to interpret it for him and thereby save the kingdom.Robert L. Woodson identifies with Joseph -- seeing in him an example of the men and women who battle daily to change the lives in our poorest neighborhoods. While many such Josephs exist, Woodson argues, their efforts are too often ignored or disparaged by Pharaoh's courtiers -- the people who operate today's social service networks. Always accessible and colorful, this powerful appeal for the health of America's inner cities can resurrect the passion to fight poverty -- but only through the vision and deeds of the street-level heroes whose efforts and voices we must heed.
Modelos de comportamento de busca de informação: contribuições para a Organização da Informação

With the development of the Web and, consequently, of the digital libraries, open archives, repositories between other, new systems and information sources have been created, placing the users in a new search and information retrieval environment, characterized by the abundance of informational resources disposed in the hypertext format, increasing the access possibilities significantly. Ahead of this ‘information digital environment’, one of the Indexing Languages functions is to represent the information of the documents contained in these information systems, so that the user be capable to access that information for the use, communication and, mainly, for the generation of new knowledge. However, the problem-key of the Information Retrieval goes by the search of theoretical and methodological proceedings for the Information Organization and Representation. In other words, the principal problematic is to find means of improving the methods of Information Organization at the conceptual level, in way to increase the accessibility for the end-users. Ahead this, an exploratory study of theoretical analysis was proposed of some information search behavior models that, in agreement with the specialized literature, they are the ones that have larger impact in research terms in the area. Such models can be incorporate to the information thematic treatment processes, allowing to librarians and indexers the if give bill of the intervening variables in the search and information retrieval process of the users and, this way, that they understand the factors that affect the information organization and representation. As results are considered that an approach that tries to place the user in the center of the concerns in the Information Organization should appeal to the accumulated experience in the calls studies of users. It is ended that the studies about the users' information behaviors, that include the contextual factors that intervening in these behaviors, can contribute for the development of new systems and tools for the Information Organization and Representation, as well as for the use of the information, be in the academics/scientifics contexts or, still, in other types of organizations.
Impact of Hydrous Manganese and Ferric Oxides on the Behavior of Aqueous Rare Earth Elements (REE): Evidence from a Modeling Approach and Implication for the Sink of REE

In this study, models were used for the first time to investigate the fate and transport of rare earth elements (REE) in the presence of hydrous manganese and ferric oxides in groundwaters from the coastal Bohai Bay (China). Results showed that REE sorption is strongly dependent on pH, as well as hydrous manganese and ferric oxide content. Higher proportions of REE were sorbed by hydrous manganese oxide as compared to hydrous ferric oxides, for example in the presence of neodymium. In this case, a mean 28% of this element was sorbed by hydrous manganese oxide, whereas an average 7% sorption was observed with hydrous ferric oxides. A contrasting REE sorption behavior was observed with hydrous manganese and ferric oxide for all investigated groundwaters. Specifically, REE bound to hydrous manganese oxides showed decreasing sorption patterns with increasing atomic number. The opposite trend was observed in the presence of hydrous ferric oxides. In addition, these results suggested that light REE (from La to Sm) rather than heavy REE (from Eu to Lu) are preferentially scavenged by hydrous manganese oxide. However, the heavy REE showed a greater affinity for hydrous ferric oxides compared to light REE. Therefore, both hydrous manganese and ferric oxide are important scavengers of REE. This study shows the implication of hydrous manganese and ferric oxide sorption for the sink of REE in groundwater.
Structure and function of Rnt1p: An alternative to RNAi for targeted RNA degradation

The double‐stranded RNA‐binding protein (dsRBP) family controls RNA editing, stability, and function in all eukaryotes. The central feature of this family is the recognition of a generic RNA duplex using highly conserved double‐stranded RNA‐binding domain (dsRBD) that recognizes the characteristic distance between the minor grooves created by the RNA helix. Variations on this theme that confer species and functional specificities have been reported but most dsRBPs retain their capacity to bind generic dsRNA. The ribonuclease III (RNase III) family members fall into four classes, represented by bacterial RNase III, yeast Rnt1p, human Drosha, and human Dicer, respectively. Like all dsRBPs and most members of the RNase III family, Rnt1p has a dsRBD, but unlike most of its kin, it poorly binds to generic RNA helices. Instead, Rnt1p, the only known RNase III expressed in Saccharomyces cerevisiae that lacks the RNAi (RNA interference) machinery, recognizes a specific class of stem‐loop structures. To recognize the specific substrates, the dsRBD of Rnt1p is specialized, featuring a αβββααα topology and a sequence‐specific RNA‐binding motif at the C‐terminus. Since the discovery of Rnt1p in 1996, significant progress has been made in studies of its genetics, function, structure, and mechanism of action, explaining the reasons and mechanisms for the increased specificity of this enzyme and its impact on the mechanism of RNA degradation.
Cardiac Rehabilitation Program with High Intensity Aerobic Exercise Can Reverse Diastolic Impairment in Patients Undergoing Coronary Artery Bypass Surgery

Background: Cardiac rehabilitation is known as a powerful non-pharmacological approach for improving functional capacity, and left ventricular systolic function; however, some limited data have suggested an attenuation of the decline in diastolic function with this program. This study investigated the effect of high intensity aerobic exercise following coronary artery bypass surgery (CABG) on diastolic dysfunction. Materials and Methods: Forty four patients with different levels of diastolic dysfunction who underwent CABG surgery were included. The participants attended the complete cardiac rehabilitation program three times per week for two months (totally 24 sessions). The patients underwent complete transthoracic echocardiographic studies including two-dimensional and spectral Doppler echocardiography immediately before attending rehabilitation program and also after the completion of rehabilitation sessions. Results: There was a significant decrease of isovolumic relaxation time (IVRT) after participating complete cardiac rehabilitation (94.0 to 89.0; P=0.001). The diastolic function parameters of early diastolic mitral inflow peak velocity to late diastolic mitral inflow peak velocity (E/A) ratio (0.94 to 1.04; P=0.001), deceleration time (DT) of the mitral E wave (192.7 to 219.0; P=0.011), and velocity of early diastolic mitral annular motion (Ea) (5.9 to 6.7; P=0.026) were improved after the rehabilitation, whereas mitral A duration to pulmonary A duration (MAD/PAD) ratio was slightly improved (1.07 to 1.12; P=0.056) and pulmonary veins systolic flow to pulmonary vein diastolic flow (PVS/PVD) ratio (0.89 to 1.04; P=0.345) remained unchanged. Conclusion: A complete cardiac rehabilitation program with high intensity aerobic exercise approach can reverse diastolic impairment in patients undergoing CABG.
Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering

The discovery of bioactive glasses (BGs) in the late 1960s by Larry Hench et al. was driven by the need for implant materials with an ability to bond to living tissues, which were intended to replace inert metal and plastic implants that were not well tolerated by the body. Among a number of tested compositions, the one that later became designated by the well-known trademark of 45S5 Bioglass® excelled in its ability to bond to bone and soft tissues. Bonding to living tissues was mediated through the formation of an interfacial bone-like hydroxyapatite layer when the bioglass was put in contact with biological fluids in vivo. This feature represented a remarkable milestone, and has inspired many other investigations aiming at further exploring the in vitro and in vivo performances of this and other related BG compositions. This paradigmatic example of a target-oriented research is certainly one of the most valuable contributions that one can learn from Larry Hench. Such a goal-oriented approach needs to be continuously stimulated, aiming at finding out better performing materials to overcome the limitations of the existing ones, including the 45S5 Bioglass®. Its well-known that its main limitations include: (i) the high pH environment that is created by its high sodium content could turn it cytotoxic; (ii) and the poor sintering ability makes the fabrication of porous three-dimensional (3D) scaffolds difficult. All of these relevant features strongly depend on a number of interrelated factors that need to be well compromised. The selected chemical composition strongly determines the glass structure, the biocompatibility, the degradation rate, and the ease of processing (scaffolds fabrication and sintering). This manuscript presents a first general appraisal of the scientific output in the interrelated areas of bioactive glasses and glass-ceramics, scaffolds, implant coatings, and tissue engineering. Then, it gives an overview of the critical issues that need to be considered when developing bioactive glasses for healthcare applications. The aim is to provide knowledge-based tools towards guiding young researchers in the design of new bioactive glass compositions, taking into account the desired functional properties.
Comparison of Clinical Manifestations, Antimicrobial Susceptibility Patterns, and Mutations of Fluoroquinolone Target Genes between Elizabethkingia meningoseptica and Elizabethkingia anophelis Isolated in Taiwan

Elizabethkingia meningoseptica and Elizabethkingia anophelis are two major pathogens in the genus Elizabethkingia. Studies have revealed that Elizabethkingia anophelis is frequently misidentified as E. meningoseptica. Therefore, our aim was to explore the clinical and molecular differences between these two species. The database of a clinical microbiology laboratory in a university-affiliated hospital of Taiwan was searched to identify patients with Elizabethkingia infections between January 2005 and June 2018. Species were reidentified using 16S ribosomal RNA gene sequencing. Twenty E. meningoseptica and 72 E. anophelis samples were collected from consecutive patients. E. meningoseptica was significantly more frequently isolated from the cerebrospinal fluid than was E. anophelis. The most susceptible antibiotic for all Elizabethkingia isolates was minocycline (91.3%), followed by levofloxacin (52.2%), tigecycline (23.9%), and piperacillin tazobactam (23.9%). Compared with E. anophelis, E. meningoseptica was significantly less susceptible to piperacillin tazobactam, minocycline, and levofloxacin. Regarding nonsynonymous substitutions in the quinolone-resistance determining regions of DNA gyrase, six sites were recognized in E. meningoseptica and one site was recognized in E. anophelis. E. meningoseptica had a significantly higher rate of fluoroquinolone target gene mutations than did E. anophelis. Because of less susceptibility to multiple antibiotics than E. anophelis, empirical antimicrobial therapy of E. meningoseptica should be more rigorous.
Case of autoimmune intraepidermal and subepidermal blistering disease in which autoantibodies to desmoglein 1 and BP230 coexist

Dear Editor, Among the antibodies found in autoimmune bullous diseases, desmoglein (Dsg)1 is an autoantigen in patients with intraepidermal blistering diseases such as pemphigus foliaceus (PF), whereas BP230 is a common target of autoantibodies in patients with bullous pemphigoid (BP). The coexistence of these autoantibodies in a patient has rarely been reported. We herein report a case showing mixed features of PF and BP associated with autoantibodies to both Dsg1 and BP230.
Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis

Aging is a complex and progressive process characterized by physiological and functional decline with time that increases susceptibility to diseases. Aged-related functional change is accompanied by a low-grade, unresolved chronic inflammation as a major underlying mechanism. In order to explain aging in the context of chronic inflammation, a new integrative concept on age-related chronic inflammation is necessary that encompasses much broader and wider characteristics of cells, tissues, organs, systems, and interactions between immune and non-immune cells, metabolic and non-metabolic organs. We have previously proposed a novel concept of senescent (seno)-inflammation and provided its frameworks. This review summarizes senoinflammation concept and additionally elaborates modulation of senoinflammation by calorie restriction (CR). Based on aging and CR studies and systems-biological analysis of Omics big data, we observed that senescence associated secretory phenotype (SASP) primarily composed of cytokines and chemokines was notably upregulated during aging whereas CR suppressed them. This result further strengthens the novel concept of senoinflammation in aging process. Collectively, such evidence of senoinflammation and modulatory role of CR provide insights into aging mechanism and potential interventions, thereby promoting healthy longevity.
Evaluating the Impact of Prescribed Versus Nonprescribed Benzodiazepine Use in Methadone Maintenance Therapy: Results From a Population-based Retrospective Cohort Study

Objectives: Benzodiazepine (BZD) use is common in patients who are engaged in methadone as a treatment for opioid use disorder. BZD prescribing is generally discouraged for this patient population due to the increased risk of BZD dependence and BZD use disorder, medication-assisted treatment (MAT) discontinuation, and opioid-overdose death. However, some patients have concurrent mental health disorders, where BZD use may be clinically indicated. This study evaluates the impact of prescribed BZD on MAT outcomes. Methods: Linking urine drug screening data (UDS) and prescribing information from single-payer health records, we conducted a retrospective Kaplan–Meier analysis between patients using prescribed and nonprescribed BZD with methadone treatment retention as the primary outcome. Data are from a network of 52 outpatient clinics in Ontario, Canada, between January 1, 2006 and June 30, 2013. Results: We identified 3692 patients initiating methadone-assisted treatment for the first time; 76% were BZD−/UDS− (no BZD prescription and <30% screens positive for BZD); 13% were BZD+/UDS−; 6% BZD−/UDS+; and 6% BZD+/UDS+. Using 1-year treatment retention as a primary outcome, patients using nonprescribed BZD (BZD−/UDS+) were twice as likely (adjusted odds ratio 0.38, 95% confidence interval 0.27–0.53) to discontinue treatment as those not using BZD (BZD−/UDS−), or those using BZD in a prescribed manner (BZD+/UDS+). Conclusions: Our findings suggest that prescribed BZD can be used during methadone MAT without impacting a patient's retention in MAT, but nonprescribed BZD use is predictive of treatment discontinuation. Importantly, we urge both the physician and patient to seek alternative clinical options to BZD prescribing, due to the potential for developing physical dependence (and BZD use disorder) to BZD and the risks of negative interactions with opioids.
VO2(B)/Graphene Composite-Based Symmetrical Supercapacitor Electrode via Screen Printing for Intelligent Packaging

More multipurpose and convenient demand driven by Radio Frequency Identification (RFID) and intelligent packaging require flexible power sources. A VO2(B)/graphene (VO2(B)/GN) core-shell composite was successfully synthesized by the hydrothermal treatment with V2O5 and graphite. The as-obtained sample was characterized by XRD, FT-IR, SEM, TEM, and XPS measurements. In addition, the electrochemical properties of VO2(B)/GN were tested. Due to its great electrochemical performance and mechanical properties, graphene could increase the electrochemical performance and strengthen the structural stability of the material at the same time. With increasing loading amount of GN, the specific capacitance of VO2(B)/GN increased correspondingly. With 20% GN loading, the initial discharge specific capacity could reach 197 F g−1 at 0.5 A g−1, and 160 F g−1 at 1 A g−1 in 0.5 M Na2SO4 electrolyte, which is better than that of pure rod-like VO2(B). The capacitance of the VO2(B)/GN (20%) composite electrode retains 95.49% after 1000 cycles, which is higher than that of a pure VO2(B) electrode (85.43%), indicating that the VO2(B)/GN composite possesses better cycling stability. Moreover, a symmetrical solid-state supercapacitor (SCs) using VO2(B)/GN(20%) as the anode was assembled. Four printed SCs were connected in series to light up a 1.5 V red LED. This demonstrates its potential application in intelligent packaging to trace food safety.
Transmission Power Control for IEEE 802.15.6 Body Area Networks

Energy consumption is an important issue in body area networks (BANs). In this letter, we propose an energy efficient transmission power control scheme for IEEE 802.15. 6 BANs, which can improve energy efficiency by adaptively adjusting the transmit power in an on‐demand way to adapt to varying channel environments. Simulations are performed to evaluate the performance, and it is shown that the proposed power control scheme outperforms traditional ones in terms of energy efficiency without significant reliability degradation.
Multidelay multiparametric arterial spin labeling perfusion MRI and mild cognitive impairment in early stage Parkinson's disease

Mild cognitive impairment (MCI), a well‐defined nonmotor manifestation of Parkinson's disease (PD), greatly impairs functioning and quality of life. However, the contribution of cerebral perfusion, quantified by arterial spin labeling (ASL), to MCI in PD remains poorly understood. The selection of an optimal delay time is difficult for single‐delay ASL, a problem which is avoided by multidelay ASL. This study uses a multidelay multiparametric ASL to investigate cerebral perfusion including cerebral blood flow (CBF) and arterial transit time (ATT) in early stage PD patients exhibiting MCI using a voxel‐based brain analysis. Magnetic resonance imaging data were acquired on a 3.0 T system at rest in 39 early stage PD patients either with MCI (PD‐MCI, N = 22) or with normal cognition (PD‐N, N = 17), and 36 age‐ and gender‐matched healthy controls (HCs). CBF and ATT were compared among the three groups with SPM using analysis of variance followed by post hoc analyses to define regional differences and examine their relationship to clinical data. PD‐MCI showed prolonged ATT in right thalamus compared to both PD‐N and HC, and in right supramarginal gyrus compared to HC. PD‐N showed shorter ATT in left superior frontal cortex compared to HC. Prolonged ATT in right thalamus was negatively correlated with the category fluency test (p = .027, r = −0.495) in the PD‐MCI group. This study shows that ATT may be a more sensitive marker than CBF for the MCI, and highlights the potential role of thalamus and inferior parietal region for MCI in early stage PD.
The inhibitory effects of Qingchang Wenzhong granule on the interactive network of inflammation, oxidative stress, and apoptosis in rats with dextran sulfate sodium‐induced colitis

Ulcerative colitis (UC) is a kind of complex immune disease, the pathogenesis of which remains elusive. Destruction of the intestinal barrier, extreme inflammation, oxidative stress, and apoptosis might play key roles in the development of UC. In previous studies, we observed that Qingchang Wenzhong granule (QCWZG) had the exact effect on the remission of UC in the clinic; however, the underlying mechanism has not been identified. This study aimed to reveal the effects of QCWZG on the intestinal physical barrier and the interactive network of inflammation, oxidative stress, and apoptosis in rats with dextran sulfate sodium (DSS)–induced colitis.