Miracle-dz/UniFAR-FTUs huggingface dataset:
Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin.

BACKGROUND Heparin-induced thrombocytopenia, defined by the presence of heparin-dependent IgG antibodies, typically occurs five or more days after the start of heparin therapy and can be complicated by thrombotic events. The frequency of heparin-induced thrombocytopenia and of heparin-dependent IgG antibodies, as well as the relative risk of each in patients given low-molecular-weight heparin, is unknown. METHODS We obtained daily platelet counts in 665 patients in a randomized, double-blind clinical trial comparing unfractionated heparin with low-molecular-weight heparin as prophylaxis after hip surgery. Heparin-induced thrombocytopenia was defined as a decrease in the platelet count below 150,000 per cubic millimeter that began five or more days after the start of heparin therapy, and a positive test for heparin-dependent IgG antibodies. We also tested a representative subgroup of 387 patients for heparin-dependent IgG antibodies regardless of their platelet counts. RESULTS Heparin-induced thrombocytopenia occurred in 9 of 332 patients who received unfractionated heparin and in none of 333 patients who received low-molecular-weight heparin (2.7 percent vs. 0 percent; P = 0.0018). Eight of the 9 patients with heparin-induced thrombocytopenia also had one or more thrombotic events (venous in 7 and arterial in 1), as compared with 117 of 656 patients without heparin-induced thrombocytopenia (88.9 percent vs. 17.8 percent; odds ratio, 36.9; 95 percent confidence interval, 4.8 to 1638; P < 0.001). In the subgroup of 387 patients, the frequency of heparin-dependent IgG antibodies was higher among patients who received unfractionated heparin (7.8 percent, vs. 2.2 percent among patients who received low-molecular-weight heparin; P = 0.02). CONCLUSIONS Heparin-induced thrombocytopenia, associated thrombotic events, and heparin-dependent IgG antibodies are more common in patients treated with unfractionated heparin than in those treated with low-molecular-weight heparin.
Diversity and Relevance in Social Search.

We propose the use of social features in studying diversity. The surge of social network engagements has led to growing insights on how an individual’s connections view the world via opinions, likes, status updates, and their own connections. In information seeking scenarios that require sensemaking, these social signals can be leveraged to increase the diversity of search results and summarize one’s network view on the query topic by pivoting on various social cues such as friend circle, expertise, and affinity. This position paper makes the case for incorporating social cues as a diversification tool and through user scenarios discusses the interplay between social cues and the sensemaking process.
Debt collection.

I. Overview §9.1 II. Preliminary Considerations A. Types of Collection Cases §9.2 B. Forwarders and Receivers §9.3 C. The Advantages to the Client of Using a Collection Agency §9.4 III. State and Federal Legislation of Importance to Debt Collectors §9.5 IV. Operating a Debt Collection Practice A. Establishing Fee Structures 1. In General §9.6 2. Contingent Fees §9.7 3. Piecework Fees §9.8 4. Hourly Fees §9.9 5. Ensuring That a Collection Practice Is Profitable §9.10 B. Efficient Office Systems §9.11 V. Contacting and Settling with the Debtor A. Contact with the Debtor §9.12 B. The Debtor’s Reply 1. Commercial Claims §9.13 2. Retail or Consumer Claims §9.14 3. The Importance of Being a Good Listener §9.15 C. Tone §9.16 D. Settlement and Payment Programs Before Filing Suit §9.17 VI. The Collection Suit A. The Prima Facie Case §9.18 B. Affidavits of Open Accounts or Accounts Stated §9.19 C. Suits on Negotiable Instruments, Guaranty Instruments, or Bills of Lading §9.20 D. Service of Process §9.21 E. The Complaint §9.22 VII. Payment Programs After the Suit Has Begun A. Essential Provisions §9.23 B. Acceleration §9.24 C. Other Provisions §9.25
Clinical efficacy of attentional bias modification procedures: an updated meta-analysis.

CONTEXT Attentional bias modification (ABM) treatment is a promising intervention tool for a variety of clinical conditions. OBJECTIVES This study provides an updated review of the clinical effect of ABM by employing standard meta-analytic procedures to (a) estimate the average effect size of ABM in reducing both attention bias (AB) and symptoms, (b) estimate the average effect size for different conditions (e.g., anxiety, depression, and substance abuse), (c) test possible variables that may moderate the effect sizes, and (d) investigate the relationship between preexistent AB and the reduction in AB and symptoms. METHOD We included 43 controlled trials with a total of 2,268 participants providing 47 group comparisons (i.e., training vs. control condition). Inclusion criteria were as follows: AB was specifically targeted to reduce symptomatology and emotional vulnerability; participants were randomized to the experimental conditions; a control condition (defined as sham training) existed; symptoms were assessed at least postintervention; sufficient data were provided to allow effect size estimation. RESULTS We obtained a small overall effect size on symptoms postintervention, g = 0.160, 95% confidence interval (CI) = [0.055, 0.265], driven by anxiety studies, g = 0.260, 95% CI = [0.132, 0.388], and studies conducted in healthy participants, g = 0.211, 95% CI = [0.046, 0.375]; no significant effect sizes were found postintervention for other symptom categories. CONCLUSION The therapeutic benefit of ABM is rather small for anxiety, while the amount of data for other symptom categories is limited. We argue that more efficient, psychometrically sound procedures are needed for assessing and modifying AB.
Discontinuity-capturing directional dissipation (DCDD) in computation of turbulent flows

Abstract. Stabilized formulations are now widely used in the computation of turbulent flows. The Streamline-Upwind/Petrov-Galerkin (SUPG) and Pressure-Stabilizing/PetrovGalerkin (PSPG) methods are among the most popular stabilized formulations. The Discontinuity Capturing Directional Dissipation (DCDD) was first introduced as a complement to the SUPG and PSPG stabilizations for the computation of incompressible flows in the presence of sharp solution gradients. The DCDD stabilization takes effect where there is a sharp gradient in the velocity field and introduces dissipation in the direction of that gradient. The length scale used in defining the DCDD stabilization is based on the solution gradient. Here we describe how the DCDD stabilization, in combination with the SUPG and PSPG stabilizations, can be applied to computation of turbulent flows. We examine the similarity between the DCDD stabilization and a purely dissipative energy cascade model. To evaluate the performance of the DCDD stabilization, we compute as test problems a plane channel flow and an axial flow fan rotor.
Functional Analysis of the RING-Type Ubiquitin Ligase Family of Arabidopsis1[w]

Approximately 5% of the Arabidopsis (Arabidopsis thaliana) proteome is predicted to be involved in the ubiquitination/26S proteasome pathway. The majority of these predicted proteins have identity to conserved domains found in E3 ligases, of which there are multiple types. The RING-type E3 is characterized by the presence of a cysteine-rich domain that coordinates two zinc atoms. Database searches followed by extensive manual curation identified 469 predicted Arabidopsis RING domain-containing proteins. In addition to the two canonical RING types (C3H2C3 or C3HC4), additional types of modified RING domains, named RING-v, RING-D, RING-S/T, RING-G, and RING-C2, were identified. The modified RINGs differ in either the spacing between metal ligands or have substitutions at one or more of the metal ligand positions. The majority of the canonical and modified RING domain-containing proteins analyzed were active in in vitro ubiquitination assays, catalyzing polyubiquitination with the E2 AtUBC8. To help identity regions of the proteins that may interact with substrates, domain analyses of the amino acids outside the RING domain classified RING proteins into 30 different groups. Several characterized protein-protein interaction domains were identified, as well as additional conserved domains not described previously. The two largest classes of RING proteins contain either no identifiable domain or a transmembrane domain. The presence of such a large and diverse number of RING domain-containing proteins that function as ubiquitin E3 ligases suggests that target-specific proteolysis by these E3 ligases is a complex and important part of cellular regulation in Arabidopsis.
Clinical tests of the sacroiliac joint. A systematic methodological review. Part 1: Reliability.

In the literature concerning the sacroiliac joint (SIJ) there are numerous specific tests used to detect joint mobility or pain provocation. In this article the authors have reviewed 11 studies which investigated the reliability of these tests. The methodological quality of the studies was tested by a list of criteria developed by the authors. This list consisted of three categories: (1) study population, (2) test procedures and (3) test results. To each criterion a weighting was attached. The methodological score for nine out of the 11 studies was found to be acceptable. The results of this review, however, could not demonstrate reliable outcomes and therefore no evidence on which to base acceptance of mobility tests of the SIJ into daily clinical practice. There are no indications that 'upgrading' of methodological quality would have improved the final conclusions. With respect to pain provocation tests, the findings did not show the same trend. Two studies demonstrated reliable results using the Gaenslen test and the Thigh thrust test. One study showed acceptable reliability for five other pain provocation tests; however, since other authors have described contradictory results, there is a necessity for further research in this area with an emphasis on multiple test scores and pain provocation tests of the SIJ.
Moderate Effect of Customer Orientation and Supplier Participation on Relationship between Process Innovation and Corporate Performance in Chinese Manufacturing Companies

The primary purpose of this study is to conceptualize process innovation, customer orientation, and supplier participation, and investigate the causal relationships between process innovation and corporate performance through empirical analysis. Furthermore, it examines whether customer orientation and supplier participation have moderating effects on the relationship between process innovation and corporate performance. To confirm our theories, we have conducted a sample survey of 187 Chinese manufacturing companies, which produced the following results. First, product innovation has a positive effect on corporate performance. Second, customer orientation has a significant positive moderating effect on the relationship between process innovation and corporate performance, while supplier participation does not. From these results, we derive managerial implication on the compatibility of process innovation and customer orientation and their simultaneous pursuance to improve the performance of Chinese manufacturing industries.
Factors that drive Coopetition and exploration of potential Supply-Based Drivers to Coopetition

Although coopetition has received more and more attention over the past couple of years, researchers have given little attention to coopetition for supply. In practice a lot of companies coopete for supply, but in literature this practice has been neglected almost completely. This study aims to provide an overview of the current knowledge about drivers for coopetitive relationships and expands this knowledge with the data of two case studies involved in coopetitive relationships for supply purposes. The overview of drivers for coopetitive relationships in the field of Supply Management provides managers with an idea of occurrences that can be tackled by involvement in coopetitive relationships.
Decidable Subsets of CCS based on the paper with the same title by Christensen , Hirshfeld and Moller from 1994

Process algebra is a very interesting framework for describing and analyzing concurrent systems. Therefore CCS is used very often and considered pretty important. But it is undecidable if two CCS agents are bisimilar. Luckily Christensen, Hirshfeld and Moller showed 1994 in their paper “Decidable Subsets of CCS” that bisimulation for CCS without communication or without restriction and relabelling is decidable. As this subset is powerful enough for many problems, this is an interesting discovery. In addition they derived a complete axiomatisation for these two sublanguages. I want to present this work.
Exploring the Black Box: Investment Banking Compensation and IPO Pricing

Using a large sample of initial public offerings (I POs) from 1985-2008, we study how the compensation of the investment banks participating in an IPO affects the pricing of the offer. We show that shifting investment bank compensation tow ard the selling concession (away from management fees and/or underwriting fees) has a sig nificant impact on the offer price of the IPO. That is, redistributing compensation toward the inv estment banks in the selling group increases the average price revision from the initial filing range. This result is robust to a number of controls and endogeneity concerns, and is statistic ally and economically significant.
Research on the Innovation of Enterprise Financial Management Based on the Internet

with the development of network technology, the survival environment of enterprises has changed significantly, and many traditional business methods are gradually being replaced by electronic shopping, electronic payment and other electronic commerce, which has led to a great change in the environment of enterprises financial management. At present, many enterprises are faced with financial management problems, which seriously restricts the sustainable development of enterprises. Therefore, the reform of enterprise financial management model is very necessary. Based on the author's many years of work experience, firstly, this paper analyzes the significance of the transformation of enterprise financial management under the network environment, then it discusses the main problems faced by enterprises in the process of financial management transformation, at last, it puts forward the strategies of enterprise financial management innovation under the network environment.
Idebenone treatment in Friedreich patients: One-year-long randomized placebo-controlled trial

86% of control values and more. Mean absolute volumes of extrastriatal areas showed large standard deviations in the HD group resulting in considerable overlap between HD and controls. Using a general linear model for correlated data (GLM-CD), the authors concluded that extrastriatal volume reductions in HD were not due to chance. Because the standard deviations for HD patients were substantially higher than for controls (e.g., cerebral exterior 159.79 versus 9.96), we wonder whether this inhomogeneity is compatible with the assumptions of a GLM-CD. Furthermore, it is unclear how structure volumes were “adjusted” for total brain volumes (do the values given represent percentages of individual total brain volumes? ) and whether the denominator “total brain volume” refers to the volume of all brain tissues or to the internal volume of the skull; only the latter would not be subject to changes in the course of the disease. In addition, in our view the use of a ROI-based technique as primary method of analysis has several drawbacks. First, robust changes in areas not defined as ROI, e.g., the hypothalamic area, which exhibited significant changes in our morphometric study3 as well as in neuropathologic studies,5 were missed. Second, we are concerned that ROI definitions such as “cerebral gray” may be misleading because multiple areas with potentially variable natural history in terms of degeneration are lumped together. In addition, the surprising observation that the nucleus accumbens appears as atrophic as the caudate in the present study (which is at odds with numerous neuropathologic studies2) might reflect difficulties in interactively outlining this ROI in pathologically altered brain scans. The demonstration of quantitative extrastriatal volume loss may be of limited use in the context of clinical trials given a marked interindividual variability: disease progression may be far more robustly reflected in striatal volume changes. Longitudinal studies will show whether subregional striatal alterations can be used as progression markers in clinical trials and whether they are more reliably captured using voxelbased or ROI-based approaches.
Self-interference elimination by physical feedback channel in CCFD for 3-D beamforming communication

The 3-D beamforming scheme has elite as evolving interest because of its efficiency to empower assorted techniques such as vertical and horizontal domains and emanation beamforming according to subscriber's provisions. Usually, 3-D beamforming communication is set up on FDD/TDD approach those effects on the performance of spectrum and energy efficiency. Co-frequency and Co-Time Full Duplex (CCFD) is an effective solution to improve the spectrum and energy efficiency by transmitting and receiving simultaneously in frequency and time domain. While, CCFD communication often face the self-interference issue when communication occurs, simultaneously. Consequently, in this paper a self-interference elimination by physical feedback channel in CCFD for 3-D Beam-forming communication scheme is proposed to improve the over-all system performance in terms of energy and spectrum efficiency. The simulation and analytical outcomes demonstrated that the proposed system is superior than the traditional one.
Animal model for assessment of skin irritancy

Irritant skin reactions from repeated open applications of low concentrations of sodium lauryl sulphate (SLS) have been studied microscopically and microscopically in guinea pigs. After 3 applications daily for 3 days. 2% SLS aqueous solutions gave a naked eye assessment, increase in epidermal thickness and total dermal inflammatory cell response, which was greater than for a 1% SLS solution. The dermal inflammatory cell response was mainly mononuclear (lymphocytic) in nature. With the SLS reactions as control, various organic solvents were studied and ranked against the SLS reactions and internally. Trichlorethylene was the most irritant solvent, ranking as high as 2% SLS Other chlorinated hydrocarbons and aromatic hydrocarbons tested caused irritant reactions. The alcohols and acetone gave no reaction. White spirit was us irritant as trichlorethylene. Thinners were less irritant, around the level of the 1% SLS control reaction. The 4‐day experimental design is a convenient and suitable animal model for screening irritant potential, and provides information relevant to the pathogenesis of irritant contact reactions
Optimum channel coding rate and spreading factor values achieving one-cell frequency reuse in downlink VSF-spread OFDM packet radio access

This paper investigates the optimum minimum coding rate of a very-low-rate Turbo coding and spreading factor value that achieves one-cell frequency reuse in Variable Spreading Factor (VSF)-Spread Orthogonal Frequency Division Multiplex- ing (OFDM) radio access in the downlink. Simulation results show that the optimum minimum coding rate is approximately R = 1/5 to 1/9 to obtain a clear additional coding gain from random code spreading. Moreover, by applying hybrid ARQ with packet combining, the required spreading (repetition) factor value can be decreased by the time diversity gain associated with soft-com- bining, compared to the case without ARQ. Accordingly, we show that the spreading factor of 8, 4, and 2 is necessary in addition to Turbo coding with R = 1/8 when the maximum number of retrans- missions in hybrid ARQ with packet combining is 0, 1, and 3 times, respectively, in order to achieve one-cell frequency reuse at the required residual packet error rate of 10 -3 for a cell radius of 1 km with 46-dBm transmission power in a 10-MHz channel bandwidth. Furthermore, for a large cell radius such as greater than 2 km, a large spreading factor of greater than 16 is required to mitigate the influence of background noise under such noise limited conditions. I. INTRODUCTION
Effects of tibolone and continuous combined hormone replacement therapy on mammographic breast density.

OBJECTIVE Our purpose was to compare the effects of tibolone, continuous combined hormone replacement therapy, and placebo on mammographic breast density. STUDY DESIGN A prospective, randomized, double-blind placebo-controlled study was performed. A total of 166 postmenopausal women were equally randomized to receive tibolone 2.5 mg, estradiol 2 mg/norethisterone acetate 1 mg (E(2)/NETA), or placebo. Mammograms were performed at baseline and after 6 months of treatment. Mammographic density was quantified according to the Wolfe classification and by the percentage area of the breast that had a dense pattern. RESULTS An increase in mammographic density was much more common among women receiving continuous combined hormone replacement therapy (46%-50%) than among those receiving tibolone (2%-6%) and placebo (0%) treatment. The difference between E(2)/NETA and placebo was highly significant (P <.001). Treatment with tibolone did not differ from that with placebo. The relative risk of an increase in breast density for E(2)/NETA versus tibolone was found to be 8.3 (95% CI 2.7-25.0). CONCLUSION An increase in mammographic density should be regarded as an unwanted side effect of hormone replacement therapy. In contrast to estrogen/progestogen treatment, tibolone seems to exert little stimulation of breast tissue.
Business and Technology Trends in Social CRM

Social media technologies have transformed the traditional CRM applications landscape in many ways. Apart from extending the traditional customer touch points, social media technologies play a critical role in integrating the activities involved in operational and analytical CRM. This chapter explores the business and technology trends in social CRM and examines current social CRM solutions and their capabilities in the analytical and operational (sales, service, and marketing) efforts of organizations. The chapter also discusses the technological and managerial challenges organizations may face in embracing social media technologies in their customer relationship management processes.
Clinical management of infections caused by multidrug-resistant Enterobacteriaceae

Enterobacteriaceae showing resistance to cephalosporins due to extended-spectrum β-lactamases (ESBLs) or plasmid-mediated AmpC enzymes, and those producing carbapenemases have spread worldwide during the last decades. Many of these isolates are also resistant to other first-line agents such as fluoroquinolones or aminoglycosides, leaving few available options for therapy. Thus, older drugs such as colistin and fosfomycin are being increasingly used. Infections caused by these bacteria are associated with increased morbidity and mortality compared with those caused by their susceptible counterparts. Most of the evidence supporting the present recommendations is from in vitro data, animal studies, and observational studies. While carbapenems are considered the drugs of choice for ESBL and AmpC producers, recent data suggest that certain alternatives may be suitable for some types of infections. Combined therapy seems superior to monotherapy in the treatment of invasive infections caused by carbapenemase-producing Enterobacteriaceae. Optimization of dosage according to pharmacokinetics/pharmacodynamics data is important for the treatment of infections caused by isolates with borderline minimum inhibitory concentration due to low-level resistance mechanisms. The increasing frequency and the rapid spread of multidrug resistance among the Enterobacteriaceae is a true and complex public health problem.