Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring Relationship-aware Dynamic Message Screening for Mobile Messengers

Mobile instant messengers lack the social appropriateness of conversation, which incurs embarrassing situations when an unwanted message is unexpectedly exposed to people nearby. To avoid such situations, we develop a relationship-aware mobile messenger that takes into account the relationship of a receiver to a sender and people nearby. Based on the in-situ relationship, it selectively shows or hides a content of incoming messages on the notification pop-up. We develop a messenger prototype and show its usefulness via a deployment study.
Towards Ultra Low-Cost Myoactivated Prostheses

In developing countries, due to the high cost involved, amputees have limited access to prosthetic limbs. This constitutes a barrier for this people to live a normal life. To break this barrier, we are developing ultra-low-cost closed-loop myoactivated prostheses that are easy to maintain manufacture and that do not require electrodes in contact with the skin to work effectively. In this paper, we present the implementation for a simple but functional hand prosthesis. Our simple design consists of a low-cost embedded microcontroller (Arduino), a wearable stretch sensor (adapted from electroresistive bands normally used for “insulation of gaskets” against EM fields), to detect residual muscle contraction as direct muscle volumetric shifts and a handful of common, not critical electronic components. The physical prosthesis is a 3D printed claw-style two-fingered hand (PLA plastic) directly geared to an inexpensive servomotor. To make our design easier to maintain, the gears and mechanical parts can be crafted from recovered materials. To implement a closed loop, the amount of closure of prosthesis is fed back to the user via a second stretch sensor directly connected to claw under the form of haptic feedback. Our concept design comprised of all the parts has an overall cost below AUD 30 and can be easily scaled up to more complicated devices suitable for other uses, i.e., multiple individual fingers and wrist rotation.
DEVELOPMENTAL PATHWAYS BETWEEN LOW BIRTH WEIGHT STATUS AND CHILDREN’S ACADEMIC AND SOCIOEMOTIONAL COMPETENCE: THE ROLE OF PARENTING PROCESSES AS A MODERATOR

The present study examined the longitudinal associations among moderate low birth weight (MLBW), parenting factors, and childrenâ€™s developmental outcomes within an at-risk sample (N= 1,809), using secondary data from Fragile Families and Child Wellbeing (FFCW) study. Of particular interest was whether parenting factors moderate the associations between MLBW and indicators of both socioemotional and cognitive/academic competence. Birth weight and prenatal data were taken from medical records. Parenting factors were assessed during in-home assessments at ages 3 and 5. Mothers and teachers reported on externalizing behaviors and teachers reported on social skills at age 9. In addition, cognitive/academic outcomes were assessed using teacher reports and standardized assessments at age 9. Overall, findings suggest that MLBW was significantly associated with teacher reports of children's socioemotional competence as well as cognitive/academic outcomes including receptive vocabulary, reading, and math achievement at age 9. These associations remained significant after accounting for a large battery of control variables; the exception was the link between MLBW status and parent's report of externalizing behavior at age 9. Results also indicated that maternal warmth, but not parenting stress, moderated the longitudinal associations between MLBW and cognitive/academic outcomes and teacher-reported socioemotional competence. To conclude, these results highlight the significance of MLBW and positive parenting processes across diverse child outcomes. The implications of these findings are discussed for interventions targeting MLBW children within at-risk populations.
Symptoms of cognitive load in interactions with a dialogue system

Humans adapt their behaviour to the perceived cognitive load of their dialogue partner, for example, delaying non-essential information. We propose that spoken dialogue systems should do the same, particularly in high-stakes scenarios, such as emergency response. In this paper, we provide a summary of the prosodic, turn-taking and other linguistic symptoms of cognitive load analysed in the literature. We then apply these features to a single corpus in the restaurant-finding domain and propose new symptoms that are evidenced through interaction with the dialogue system, including utterance entropy, speech recognition confidence, as well as others based on dialogue acts.
Altered Functional Connectivity of Amygdala with the Fronto-Limbic-Striatal Circuit in Temporal Lobe Lesion as a Proposed Mechanism for Poststroke Depression

Objective Poststroke depression (PSD) is an important complication that affects stroke rehabilitation. Abnormal cortical-subcortical connectivity may be associated with the development of PSD. However, few studies have focused on the emotional network of PSD in the temporal lobe lesions. The aim of is study was to investigate amygdala-cortical functional connectivity (FC) in the temporal lobe in individuals with and without PSD. Design Twenty-three patients with PSD and 21 stroke patients without depression were recruited to undergo functional magnetic imaging scanning. Results In stroke patients with depression, the left amygdala had increased FC with the bilateral precuneus and right orbital frontal lobe but decreased FC with the right putamen. The right amygdala had increased FC with the right temporal pole, right rectus gyrus, and left orbital frontal lobe but decreased FC with the right primary sensory area (S1). Correlative analyses revealed that the amygdala's FCs with the right orbital frontal lobe, right insular cortex, and right cingulate cortex were correlated with the Hamilton Depression Rating Scale score. Conclusion The current study identified mood affected through the fronto-limbic-striatal circuit in PSD. Hyperconnectivity between the amygdala, default mode network, and salience network might be related to depressive symptoms, which may provide novel insight into the underlying neuropathologic mechanisms of PSD in temporal lobe lesions.
Predicting early bulking in potatoes

Early bulking of potatoes is important for potato breeders for several reasons, including flexibility in scheduling and less influence of weather conditions. In this paper we use statistical models to model tuber growth in order to identify which existing varieties allow for early bulking. We also investigate which genetic properties (SNP’s) may be important for early bulking.
A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases.

BACKGROUND & OBJECTIVE Alzheimer's disease (AD) and Parkinson's disease (PD) affect an increasing number of the elderly population worldwide. The existing treatments mainly improve the core symptoms of AD and PD in a temporary manner and cause alarming side effects. Naturally occurring flavonoids are well-documented for neuroprotective and neurorestorative effects against various neurodegenerative diseases. Thus, we analyzed the pharmacokinetics of eight potent natural products flavonoids for the druggability and discussed the neuroprotective and neurorestorative effects and the underlying mechanisms. CONCLUSION This review provides valuable clues for the development of novel therapeutics against neurodegenerative diseases.
Egr-1 is involved in coronary microembolization-induced myocardial injury via Bim/Beclin-1 pathway-mediated autophagy inhibition and apoptosis activation

Coronary microembolization (CME) substantially reduces the clinical benefits of myocardial reperfusion therapy. Autophagy and apoptosis participate in the pathophysiological processes of almost all cardiovascular diseases, including CME-induced myocardial injury, but the precise underlying mechanisms remain unclear. In the present study, we observed that Egr-1 expression was substantially increased after CME modeling. Inhibition of Egr-1 expression through the targeted delivery of rAAV9-Egr-1-shRNA improved cardiac function and reduced myocardial injury. The microinfarct size was also significantly smaller in the Egr-1 inhibitor group than in the CME group. These benefits were partially reversed by the autophagy inhibitor 3-MA. As shown in our previous study, autophagy in the myocardium was impaired after CME. Inhibition of Egr-1 expression in vivo restored the autophagy flux and reduced myocardial apoptosis, at least partially, by inhibiting the Egr-1/Bim/Beclin-1 pathway, as evidenced by the results of the western blot, RT-qPCR, and TUNEL staining. At the same time, TEM showed a dramatic increase in the number of typical autophagic vacuoles in the Egr-1 inhibitor group compared to the CME group. Based on these findings, the Egr-1/Bim/Beclin-1 pathway may be involved in CME-induced myocardial injury by regulating myocardial autophagy and apoptosis, and this pathway represents a potential therapeutic target in CME.
Determination of Three Main Chlorogenic Acids in Water Extracts of Coffee Leaves by Liquid Chromatography Coupled to an Electrochemical Detector

Coffee is a beverage widely consumed in the world. The coffee species most commercialized worldwide are Arabica (Coffea arabica) and Robusta (Coffea canephora). Roasted coffee beans are the most used, but coffee leaves are also consumed as infusion in several countries for traditional medicinal purposes. They contain several interesting phenolic antioxidant compounds mainly belonging to chlorogenic acids (CGAs). In the present work, a liquid chromatography-electrochemical detection (LC-EC) method was developed for the determination of three main chlorogenic acid isomers, namely 3-, 4-, and 5-caffeoylquinic acids (CQA), in coffee leaves aqueous extracts. Samples from eight coffee species, namely; Coffea arabica, Coffea canephora, Coffea liberica, Coffea humilis, Coffea mannii, Coffea charrieriana, Coffea anthonyi, and Coffea liberica var. liberica, were grown and collected in tropical greenhouses. Linearity of the calibration graphs was observed in the range from the limit of quantification to 1.0 × 10−5 M, with R2 equal to 99.9% in all cases. High sensitivity was achieved with a limit of detection of 1.0 × 10−8 M for 3-CQA and 5-CQA (i.e., 3.5 µg/L) and 2.0 × 10−8 M for 4-CQA (i.e., 7.1 µg/L). The chromatographic profile of the samples harvested for each Coffea species was studied comparatively. Obtained raw data were pretreated for baseline variations and shifts in retention times between the chromatographic profiles. Principal Component Analysis (PCA) was applied to the pretreated data. According to the results, three clusters of Coffea species were found. In the water sample extracts, 5-CQA appeared to be the major isomer, and some species contained a very low amount of CQAs. Fluctuations were observed depending on the Coffea species and harvesting period. Significant differences between January and July were noticed regarding CQAs content. The species with the best CQAs/caffeine ratio was identified. The LC-EC data were validated by liquid chromatography-high resolution mass spectrometry (LC-HRMS).
The Role of Melanoma Cell-Stroma Interaction in Cell Motility, Invasion, and Metastasis

The importance of studying cancer cell invasion is highlighted by the fact that 90% of all cancer-related mortalities are due to metastatic disease. Melanoma metastasis is driven fundamentally by aberrant cell motility within three-dimensional or confined environments. Within this realm of cell motility, cytokines, growth factors, and their receptors are crucial for engaging signaling pathways, which both mediate crosstalk between cancer, stromal, and immune cells in addition to interactions with the surrounding microenvironment. Recently, the study of the mechanical biology of tumor cells, stromal cells and the mechanics of the microenvironment have emerged as important themes in driving invasion and metastasis. While current anti-melanoma therapies target either the MAPK signaling pathway or immune checkpoints, there are no drugs available that specifically inhibit motility and thus invasion and dissemination of melanoma cells during metastasis. One of the reasons for the lack of so-called “migrastatics” is that, despite decades of research, the precise biology of metastatic disease is still not fully understood. Metastatic disease has been traditionally lumped into a single classification, however what is now emergent is that the biology of melanoma metastasis is highly diverse, heterogeneous and exceedingly dynamic—suggesting that not all cases are created equal. The following mini-review discusses melanoma heterogeneity in the context of the emergent theme of mechanobiology and how it influences the tumor-stroma crosstalk during metastasis. Thus, highlighting future therapeutic options for migrastatics and mechanomedicines in the prevention and treatment of metastatic melanoma.
Cerebrovascular Physiology During Pediatric Extracorporeal Membrane Oxygenation: A Multicenter Study Using Transcranial Doppler Ultrasonography*

Objectives: To explore changes to expected, age-related transcranial Doppler ultrasound variables during pediatric extracorporeal membrane oxygenation. Design: Prospective, observational, multicenter study. Setting: Tertiary care PICUs. Patients: Children 1 day to 18 years old requiring veno arterial extracorporeal membrane oxygenation. Methods: Participants underwent daily transcranial Doppler ultrasound measurement of bilateral middle cerebral artery flow velocities. Acute neurologic injury was diagnosed if seizures, cerebral hemorrhage, or diffuse cerebral ischemia was detected. Measurements and Main Results: Fifty-two children were enrolled and analyzed. In the 44 children without acute neurologic injury, there was a significant reduction in systolic flow velocity and mean flow velocity compared with predicted values over time (F [8, 434] = 60.44; p ⩽ 0.0001, and F [8, 434] = 17.61; p ⩽ 0.0001). Middle cerebral artery systolic flow velocity was lower than predicted on extracorporeal membrane oxygenation days 1–5, and mean flow velocity was lower than predicted on extracorporeal membrane oxygenation days 1–3. In the six infants less than 90 days old suffering diffuse cerebral ischemia, middle cerebral artery systolic flow velocity, mean flow velocity, and diastolic flow velocity from extracorporeal membrane oxygenation days 1–9 were not significantly different when compared with children of similar age in the cohort that did not suffer acute neurologic injury (systolic flow velocity F [8, 52] = 0.6659; p = 0.07 and diastolic flow velocity F [8, 52] = 1.4; p = 0.21 and mean flow velocity F [8, 52] = 1.93; p = 0.07). Pulsatility index was higher in these infants over time than children of similar age in the cohort on extracorporeal membrane oxygenation that did not suffer acute neurologic injury (F [8, 52] = 3.1; p = 0.006). No patient in the study experienced cerebral hemorrhage. Conclusions: Flow velocities in the middle cerebral arteries of children requiring extracorporeal membrane oxygenation are significantly lower than published normative values for critically ill, mechanically ventilated, sedated children. Significant differences in measured systolic flow velocity, diastolic flow velocity, and mean flow velocity were not identified in children suffering ischemic injury compared with those who did not. However, increased pulsatility index may be a marker for ischemic injury in young infants on extracorporeal membrane oxygenation.
The Third French Individual and National Food Consumption (INCA3) Survey 2014–2015: method, design and participation rate in the framework of a European harmonization process

Abstract Objective Assessing dietary exposure or nutrient intakes requires detailed dietary data. These data are collected in France by the cross-sectional Individual and National Studies on Food Consumption (INCA). In 2014–2015, the third survey (INCA3) was launched in the framework of the European harmonization process which introduced major methodological changes. The present paper describes the design of the INCA3 survey, its participation rate and the quality of its dietary data, and discusses the lessons learned from the methodological adaptations. Design Two representative samples of adults (18–79 years old) and children (0–17 years old) living in mainland France were selected following a three-stage stratified random sampling method using the national census database. Setting Food consumption was collected through three non-consecutive 24 h recalls (15–79 years old) or records (0–14 years old), supplemented by an FFQ. Information on food supplement use, eating habits, physical activity and sedentary behaviours, health status and sociodemographic characteristics were gathered by questionnaires. Height and body weight were measured. Participants In total, 4114 individuals (2121 adults, 1993 children) completed the whole protocol. Results Participation rate was 41·5% for adults and 49·8% for children. Mean energy intake was estimated as 8795 kJ/d (2102 kcal/d) in adults and 7222 kJ/d (1726 kcal/d) in children and the rate of energy intake under-reporters was 17·8 and 13·9%, respectively. Conclusions Following the European guidelines, the INCA3 survey collected detailed dietary data useful for food-related and nutritional risk assessments at national and European level. The impact of the methodological changes on the participation rate should be further studied.
Expert consensus for the diagnosis and treatment of patient with hyperuricemia and high cardiovascular risk.

Department of Medical and Surgical Sciences, University of Bologna, Italy Department of Hypertension, Angiology and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland Department of Hypertension and Internal Medicine, Pomeranian Medical University, Szczecin, Poland First Department of Cardiology, Medical University of Warsaw, Poland Department of Internal Medicine and Cardiology with the Center for Diagnosis and Treatment of Venous Thromboembolism, Medical University of Warsaw, Poland Club 30, Polish Cardiac Society, Poland Heart and Vascular Center, Semmelweis University, Budapest, Hungary First Department of Cardiology, Medical University of Gdansk, Poland Department of Hypertension and Diabetology, Medical University of Gdansk, Poland Università Milano-Bicocca, Milan, Italy
Regulation of skeletal mineralisation by PHOSPHO1.

PHOSPHO1 is a skeletal specific phosphatase whose activity towards the lipid metabolites, phosphocholine (PCho) and phosphoethanolamine (PEth), results in the generation of inorganic phosphate (Pi) within matrix vesicles (MV). PHOSPHO1 activity is essential for the initiation of biomineralisation. The genetic ablation of Phospho1 results in severe hypomineralisation of the skeleton and dentition. Neutral sphingomyelinase 2 (nSMase2, encoded by the Smpd3 gene) catalyses the breakdown of the membrane lipid sphingomyelin to generate ceramide and PCho. Similar hypomineralisation of the skeleton is noted in the Smpd3 mouse. This observation led to the hypothesis that nSMase2 and PHOSPHO1 work in tandem for the generation
Anti-inflammatory effects of shikonin in human periodontal ligament cells

Abstract Context: Shikonin (SHI), an active component extracted from Radix Arnebiae, has been reported to possess anti-inflammatory properties in various cells. However, its effect on lipopolysaccharide (LPS)-stimulated human periodontal ligament cells (hPDLCs) is unknown. Objective: To investigate the effects of SHI on the expression of inflammatory related cytokines in LPS-stimulated hPDLCs. Materials and methods: The effects of SHI (0.125, 0.25, 0.5, 1, and 2 μg/mL) on hPDLCs proliferation for 1, 3 and 7 days were measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The expression of interleukin-1 (IL-1), IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-2 (MMP-2), MMP-9 and cyclooxygenase-2 (COX-2) were detected in hPDLCs following SHI treatment (0.25 and 0.5 μg/mL) using Quantitative Reverse Transcriptase Polymerase Chain Reaction (qRT-PCR). The signaling pathways triggered by SHI in hPDLC were evaluated using western blotting. Results: LD50 of SHI is 1.7 μg/mL (day 1) and 1.1 μg/mL (day 3 and 7) in hPDLCs. No morphological changes were observed when hPDLCs were treated with LPS only (1 μg/mL) or LPS with SHI (0.25 and 0.5 μg/mL). Data from qRT-PCR suggests that SHI attenuates LPS-induced increases of IL-1, IL-6, TNF-α, MMP-2, MMP-9 and COX-2 in hPDLCs. Down-regulation of phosphorylated extracellular signal-regulated kinase (ERK) and nuclear factor-κB (NF-κB), and up-regulation of I-κB, were observed in LPS-stimulated hPDLCs after exposed to SHI at 0.25 or 0.5 μg/mL. Discussion and conclusions: SHI possesses anti-inflammatory effects in LPS-stimulated hPDLCs via phospho-ERK and NF-κB/I-κB signaling pathways; this suggests that SHI may hold potential as an anti-inflammatory agent against periodontitis.
Virulent Epidemic Pneumonia in Sheep Caused by the Human Pathogen Acinetobacter baumannii

The human pathogen Acinetobacter baumannii has emerged as a frequent cause of hospital-acquired infections, but infection of animals has rarely been observed. Here we analyzed an outbreak of epidemic pneumonia killing hundreds of sheep on a farm in Pakistan and identified A. baumannii as the infecting agent. A pure culture of strain AbPK1 isolated from lungs of sick animals was inoculated into healthy sheep, which subsequently developed similar disease symptoms. Bacteria re-isolated from the infected animals were shown to be identical to the inoculum, fulfilling Koch’s postulates. Comparison of the AbPK1 genome against 2283 A. baumannii genomes from the NCBI database revealed that AbPK1 carries genes for unusual surface structures, including a unique composition of iron acquisition genes, genes for O-antigen synthesis and sialic acid-specific acetylases of cell-surface carbohydrates that could enable immune evasion. Several of these unusual and otherwise rarely present genes were also identified in genomes of phylogenetically unrelated A. baumannii isolates from combat-wounded US military from Afghanistan indicating a common gene pool in this geographical region. Based on core genome MLST this virulent isolate represents a newly emerging lineage of Global Clone 2, suggesting a human source for this disease outbreak. The observed epidemic, direct transmission from sheep to sheep, which is highly unusual for A. baumannii, has important consequences for human and animal health. First, direct animal-to-animal transmission facilitates fast spread of pathogen and disease in the flock. Second, it may establish a stable ecological niche and subsequent spread in a new host. And third, it constitutes a serious risk of transmission of this hyper-virulent clone from sheep back to humans, which may result in emergence of contagious disease amongst humans.
Accelerating System Log Processing by Semi-supervised Learning: A Technical Report

There is an increasing need for more automated system-log analysis tools for large scale online system in a timely manner. However, conventional way to monitor and classify the log output based on keyword list does not scale well for complex system in which codes contributed by a large group of developers, with diverse ways of encoding the error messages, often with misleading pre-set labels. In this paper, we propose that the design of a large scale online log analysis should follow the "Least Prior Knowledge Principle", in which unsupervised or semi-supervised solution with the minimal prior knowledge of the log should be encoded directly. Thereby, we report our experience in designing a two-stage machine learning based method, in which the system logs are regarded as the output of a quasi-natural language, pre-filtered by a perplexity score threshold, and then undergo a fine-grained classification procedure. Tests on empirical data show that our method has obvious advantage regarding to the processing speed and classification accuracy.