Miracle-dz/UniFAR-FTUs huggingface dataset:
Application of CAPS markers for genomic studies in wild emmer wheat

Wild emmer wheat, Triticum dicoccoides, the tetraploid progenitor of domesticated wheat, is a promising source for crop improvement. Wild wheat populations harbor broad phenotypic diversity for numerous agronomic traits such as yield, grain quality, disease resistance, tolerance to abiotic stresses, and phenological characters. Wheat is of great societal and economic importance. However, it possesses a large and complex genome due to polyploidy and a high proportion of repetitive DNA, making genomic analysis and development of markers for wheat improvement a significant challenge. Singlenucleotide polymorphisms (SNPs) are considered among the most reliable and reproducible types of sequence-based genetic markers. SNP genotyping by cleaved amplified polymorphic sequences (CAPS) and derived CAPS (dCAPS) markers are commonly used to target specific chromosome regions in genetic and breeding projects. However, the application of CAPS markers for genetic mapping in polyploid wheat is * Corresponding author: Tel: +972-4-8240-784, Fax: +972-4-8288-602, Email: fahima@research.haifa. ac.il. Dina Raats, Elitsur Yaniv, Assaf Distelfeld et al. 2 complicated by the presence of both paralogous and homoeologous gene copies. Therefore, an essential part of any mapping strategy is the development of genomespecific markers. Previously, the development of CAPS markers was based on very limited resources such as wheat expressed sequence tags (EST) and syntenic information from rice, making the allocation of loci on homoeologous genomes a very laborious task. Nevertheless, CAPS markers served as a major tool for high-resolution genetic mapping and QTL cloning of the high grain protein transcription factor Gpc-B1 and the slowrusting resistance gene, Yr36, derived from wild emmer wheat. The recent efforts to develop whole-genome sequence and chromosome-specific bacterial artificial chromosome (BAC) libraries have permitted the establishment of large-scale wheat genomics resources. An increase in wheat sequence data and the sequencing of complete model grass genomes, used to infer wheat gene content and order based on comparative genomics, had a major impact on CAPS marker development. Gene isolation projects, including the powdery mildew resistance genes PmG16 and PmG3M, as well as the stripe rust resistance genes Yr15 and YrH52 derived from wild emmer wheat, are currently underway. In these projects, the development of genome-specific CAPS primers is based on comparisons of wheat genome survey sequence data of individually sorted chromosome arms. Although high throughput development and genotyping of markers has progressed significantly in wheat, CAPS markers remain the method of choice for fine genetic dissection and positional cloning of genes derived from T. dicoccoides and other species in the genus because they provide simple analysis of complex genomes.
Technological diffusion as a recombinant process1

In this work we analyse patterns of technological development using patent applications at the United States Patent and Trademark Office (USPTO) over the 1973-2012 period. Our study focuses on the combinations of technological fields within patent documents and their evolution in time, which can be modelled as a diffusion process. By focusing on the combinatorial dimension of the process we obtain insights that complement those from counting patents. Our results show that the density of the technological knowledge network increased and that the majority of technological fields became more interconnected over time. We find that most technologies follow a similar diffusion path that can be modelled as a Logistic or Gompertz function, which can then be used to estimate the time to maturity defined as the year at which the diffusion process for a specific technology slows down. This allows us to identify a set of promising technologies which are expected to reach maturity in the next decade. Our contribution represents a first step in assessing the importance of diffusion and cross-fertilization in the development of new technologies, which could support the design of targeted and effective Research & Innovation and Industrial policies.
Dynamic pricing and inventory management in the presence of online reviews

We study the joint pricing and inventory management problem in the presence of online customer reviews. Customers who purchase the product may post reviews that would influence future customers’ purchasing behaviors. Under the common practice of customer-generated reviews on e-commerce platforms, rigorous investigation of their operational implications offers valuable insights and guidance for both the research community and practitioners. We develop a stochastic joint pricing and inventory management model to characterize the optimal policy in the presence of online reviews. We show that a rating-dependent basestock/list-price policy is optimal. Interestingly, the inventory dynamics of the firm do not influence the optimal policy as long as the initial inventory is below the initial base-stock level. Hence, we can reduce the dynamic program that characterizes the optimal policy to one with a single-dimensional state-space (the aggregate net rating). The presence of online reviews gives rise to the trade-off between generating current profits and inducing future demands, thus having several important implications upon the firm’s operations decisions. First, online reviews drive the firm to deliver a better service and attract more customers to post a review. Hence, the safety-stock and base-stock levels are higher in the presence of online reviews. Second, the evolution of the aggregate net rating process follows a mean-reverting pattern: When the current rating is low (resp. high), it has an increasing (resp. decreasing) trend in expectation. Third, although myopic profit optimization leads to significant optimality losses in the presence of online reviews, balancing the current profits and near-future demands suffices to exploit the network effect induced by online reviews. We propose a dynamic look-ahead heuristic policy that well leverages this idea and achieves small optimality gaps which decay exponentially in the length of the look-ahead time-window.
Hypermaps - Beyond occupancy grids

Intelligent and autonomous robotic applications often require robots to have more information about their environment than provided by traditional occupancy maps. An example are semantic maps, which provide qualitative descriptions of the environment. While research in the area of semantic mapping has been performed, most robotic frameworks still offer only occupancy maps. In this thesis, a framework is developed to handle multi-layered 2D maps in ROS. The framework offers occupancy and semantic layers, but can be extended with new layer types in the future. Furthermore, an algorithm to automatically generate semantic maps from RGB-D images is presented. Software tests were performed to check if the framework fulfills all set requirements. It was shown that the requirements are accomplished. Furthermore, the semantic mapping algorithm was evaluated with different configurations in two test environments, a laboratory and a floor. While the object shapes of the generated semantic maps were not always accurate and some false detections occurred, most objects were successfully detected and placed on the semantic map. Possible ways to improve the accuracy of the mapping in the future are discussed.
Role of Innovation in Small and Medium Enterprises Performance : A Case of Maize Flour Millers in Meru South Sub-Counties , Kenya

The purpose of this study was to investigate the role of innovation in Small and Medium Enterprises (SMEs) performance with a specific reference to Maize Flour Milling Enterprises in Meru South SubCounties, Kenya. The study sought to investigate the type of innovation and its role on firm performance, determine other factors influencing performance and to establish barriers to innovation among the maize flour millers. Innovation is key element in entrepreneurship and is vital to the success and growth of many organizations. Although some studies link good business performance to innovation others associate performance with other factors such as first-mover advantage and access to resources. The study adopted descriptive research survey design with the sample taken from the population using stratified random sampling method. The result indicates that only about 34% of the SMEs embraced some innovation while 58% had little or no innovation. The most innovative SMEs reported higher revenue and increased market share while less innovative SMEs recorded declining revenue and stagnation. To be competitive, SMEs need to be driving more innovation in their products, services and processes while adopting new technologies. It is therefore recommended that for the SMEs to perform well and grow, should find innovation opportunities and allocate more resources for innovative initiatives.
Executive summary

How much new information is created each year? Newly created information is stored in four physical media – print, film, magnetic and optical – and seen or heard in four information flows through electronic channels – telephone, radio and TV, and the Internet. This study of information storage and flows analyzes the year 2002 in order to estimate the annual size of the stock of new information recorded in storage media, and heard or seen each year in information flows. Where reliable data was available we have compared the 2002 findings to those of our 2000 study (which used 1999 data) in order to describe a few trends in the growth rate of information.
Fast and accurate analysis of complicated metamaterial structures using a low-frequency multilevel fast multipole algorithm

We present efficient solutions of electromagnetics problems involving realistic metamaterial structures using a low-frequency multilevel fast multipole algorithm (LF-MLFMA). Ordinary implementations of MLFMA based on the diago-nalization of the Green's function suffer from the low-frequency breakdown, and they become inefficient for the solution of metamaterial problems dis-cretized with very small elements compared to the wavelength. We show that LF-MLFMA, which employs multipoles explicitly without diagonalization, significantly improves the solution of metamaterial problems in terms of both processing time and memory.
A case study for distributed and efficient protection of communications in reconfigurable embedded systems

The development of security services in embedded systems is more and more relevant. The more we need complex treatments, the more security is involved inside such devices. This work looks after giving a trusted environment for multiprocessor communications implemented in reconfigurable technology-based architectures (such as FPGAs) with a good latency/area trade-off.
Evaluating Mental Health Disability in the Workplace: Model, Process, and Analysis

Introduction. -Taking the High Road: Ethics and Practice in Employment Evaluations. -Employment Evaluations and the Law. -Why We Work: Psychological Meaning and Effects. -Psychiatric Disorders, Functional Impairment, and the Workplace. -Psychiatric Disability: A Model for Assessment. -Practice Guidelines for Mental Health Disability Evaluations in the Workplace. -The Maze of Disability Benefit Programs: Social Security Disability, Workers' Compensation, and Private Disability Insurance. -Working with Disabilities: The Americans with Disabilities Act. -Fitness-for-Duty Evaluations. -Conclusion. -Appendix I: The American Academy of Psychiatry and the Law: Ethics Guidelines for the Practice of Forensic Psychiatry, 2005. -Appendix II: The American Psychology-Law Society, Committee on Ethical Guidelines of Division 41 of the American Psychological Association and the American Academy of Forensic Psychology: Specialty Guidelines for Forensic Psychologists, 1991. -Appendix III: The Disability Report. -References. -Legal citations
Intra-operative tumour localisation in robot-assisted minimally invasive surgery : a review

Robot-assisted Minimally Invasive Surgery has many advantages compared to conventional open surgery but also certain drawbacks: it causes less operative trauma and faster recovery times but does not allow for direct tumour palpation as is the case in open surgery. This article reviews state-of-the-art intraoperative tumour localisation methods used in Robot-assisted Minimally Invasive Surgery and in particular methods that employ force-based sensing, tactile-based sensing, and medical imaging techniques. The limitations and challenges of these methods are discussed and future research directions are proposed.
Chinese tone and intonation perceived by L 1 and L 2 listeners 1

Pitch is used in Chinese both at the word level to differentiate between four (or more) lexical tones and at the sentence level. A functional view claims that if some phonetic dimension is exploited in one area of the grammar (including the phonology) it will not be used to the same extent in another part of the phonology. We addressed the issue by asking how well learners of Chinese as a second language (L2) perceive pitch variations at word and sentence-levels. We assume that if there is competition between these two uses of pitch, we should expect L2 speakers whose native language (L1) is a tone language to be more sensitive to lexical tones and less sensitive to sentence intonation than L2 speakers whose L1 is a non-tone language. Eighty-one Chinese-speaking (Beijing dialect) subjects participated in two laboratorycontrolled perception experiments, on lexical tone and sentence intonation (statement vs. question), in which we manipulated the intonation contour of an entire utterance as well as that of the final syllable. We recruited one group of L1 listeners (native Beijing speakers) and three groups of L2 listeners, i.e. two groups with a tone-language L1 (Nantong and Changsha dialect) and one group with non-tone language L1 (Uygur, an Altaic language). Results revealed that in perceiving tones and intonation in Beijing dialect, relative to L1 performance, L2 listeners with a non-tone-language L1 (Uygur) proved less sensitive to lexical tones but were at the same time more sensitive to intonation than L2 listeners with a tone-language L1. These results support the functional view, i.e., if some phonetic dimension is exploited in one area of the grammar, e.g. lexical tones, it will not be used to the same extent in another part of the phonology, e.g. sentence intonation. CHINESE TONE AND INTONATION PERCEIVED BY L1 AND L2 LISTENERS 3
Identification of Candidate Microsatellite Markers Associated with Agronomic Traits in Rice ( Oryza sativa L . )

DIVERSE collection of Egyptian and exotic rice genotypes, were evaluated for agronomic traits. Subsequently in order to assess the allele diversity of quantitative trait loci (QTLs) attributed to agronomic traits. The genotypes were characterized using a set of 23 microsatellite markers. In total, 24 significant marker-trait associations QTLs were identified; 2 for heading date, 10 for plant height, 2 for panicle length, 4 for number of panicles per plant, 1 for number of filled grains per panicle, 1 for 1000-grain weight and 4 for grain yield per plant. More of these QTLs were located on chromosomes 2 and 7. Association analysis of SSR markers showed 4 markers RM6, RM118, RM151 and RM307 had significant association with most of agronomic traits. Detection of QTLs for agronomic traits at different chromosomes indicated that these characters are controlled by multiple loci. Higher R values were obtained for most traits and ranged from -0.366* to 0.695** for grain yield per plant and plant height, respectively. Genetic analysis identified the best rice microsatellite markers attributed to agronomic traits and they can be informative for improvement of agronomic traits through marker-assisted selection. Breeders can use this information to design crosses that assemble new potentially durable combinations of genes/QTLs to improve rice genotypes.
Ageing carers and intellectual disability: a scoping review

Purpose Individuals with intellectual disability(ies) are living longer contributing to an overall increase in the average age of caregivers. The purpose of this paper is to review the literature on the physical, social and psychological needs of ageing carers of individuals with intellectual disability(ies) in the UK. Design/methodology/approach A scoping review framework was used to identify literature from eleven databases, the grey literature and the references lists of relevant studies. Only primary research studies that discussed the needs of non-professional carers, aged 65+ years old, of individuals with intellectual disability(ies) in the UK were included. No date restrictions were applied. Thematic analysis was used to narratively synthesise findings. Findings Six studies were included. Five key themes were identified: Living with fear, lack of information, rebuilding trust, proactive professional involvement and being ignored. Housing and support information is not communicated well to carers. Professionals require more training on carer needs and trust must be rebuilt between carers and professionals. Proactive approaches would help identify carer needs, reduce marginalisation, help carers feel heard and reduce the risk of care crisis. Greater recognition of mutual caring relationships is needed. Originality/value This review highlighted the needs of older caregivers for individuals with intellectual disability(ies) as well as the need for more high-quality research in this field. The information presented in this review may be considered by primary care providers and funding bodies when planning future support for this growing population of carers.
Le reflux gastro-oesophagien de l'adulte: Quels sont les resultats des traitements medicaux? (I)

LES ANTAGONISTES DES RÉCEPTEURS HISTAMINIQUES H2 • Traitement d’attaque − Résultats et efficacité des différents anti-H 2 • Ranitidine • Cimétidine • Famotidine • Nizatidine − Tolérance − Rapport dose/efficacité des principaux anti-H 2 • Ranitidine • Cimétidine • Famotidine • Nizatidine − Efficacité comparée des anti-H 2 et des inhibiteurs de la pompe à protons • Traitement d’entretien • Effets indésirables • Ranitidine • Cimétidine • Famotidine • Nizatidine
Effect of circle therapy on breast cancer pain management

Objectives & Background: Recent studies have shown that alternative non pharmacological approaches have significant effect on pain management. Hypnosis has also been seen effective in pain management including cancer pain. The current study was conducted to assess the effect of novel hypnotic approach, called ‘circle therapy’ on pain due to breast cancer. Methodology: For this study, 60 females suffering from stage 2 breast cancer, undergoing through chemotherapy, were selected by using purposive sampling technique. An intervention plan for breast cancer patients was developed using a hypnosis technique, the ‘circle therapy’. Subjective pain rating scale was used for the pre and post assessment of the pain.Results: Repeated measure ANOVA showed a significant effect of ‘circle therapy’ on pain caused by breast cancer (p < 0.05). Conclusion: On the basis of this current research, it is concluded that hypnosis has significant effect on pain reduction due to breast cancer. This effect is for short duration; however, this positive effect may be prolonged by increasing the number of hypnotic sessions.
ACUTE PHASE PROTEINS AS MARKERS OF INFECTIOUS DISEASES IN SMALL ANIMALS

During the acute phase response, there is an increased production and release of certain proteins known as acute phase proteins (APPs) which can be produced by hepatocytes and peripheral tissues such as C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp), alpha-1 acid glycoprotein (AGP). These proteins have been investigated as markers of various infectious diseases in small animals and the purpose of this review is to update the current knowledge about APPs in infectious diseases in dogs and cats.
Design and Development of Solar-Based Water Heating System with Mechanical Sun Tracking

In this work, the effect of integrating a mechanical sun tracking system on the performance of a solar heating system was investigated. The heating system consists of a copper pipe in the form of rectangular vortex. The solar tracking system is designed and constructed mechanically through a water float associated with a tow pulley to the gearbox. The gearbox is connected to a pulley on the shaft that is connected to the parabolic trough. A programming method to control the pumping system as a function of time is used. An experimental study was conducted to investigate the performance of the solar heating system with and without tracking. The results of experimentation indicate that in the case of exposing solar heating to the sun for 15 minutes, the heating system with mechanical tracking increased water temperature from 24 C to 84 C, while the heating system without tracking increased water temperature from 24 C to 55 C. Keywords— Heating system, Mechanical sun tracking, Parabolic trough.
ASMA: DA INFÂNCIA À ADOLESCÊNCIA ASMA: DA INFÂNCIA À ADOLESCÊNCIA ASMA: DA INFÂNCIA À ADOLESCÊNCIA ASMA: DA INFÂNCIA À ADOLESCÊNCIA ASMA: DA INFÂNCIA À ADOLESCÊNCIA ASTHMA: FROM CHILDHOOD TO ADOLESCENCE

O diagnóstico de asma baseia-se em características clínicas como a obstrução do fluxo aéreo, que é parcial, se não totalmente reversível, e na hiper-responsividade brônquica, que predispõe à broncoconstrição após exposição a desencadeantes, variáveis para cada indivíduo. A inflamação e a hiper-responsividade na asma apresentam características heterogêneas e isto explica, pelo menos em parte, a resposta variável à terapêutica. O novo guia para asma, National Asthma Education Prevention Program (NAEPP), utilizado na faixa pediátrica, enfatiza a importância de monitoração regular de vários parâmetros, incluindo sintomas diurnos e noturnos, interferência com as atividades escolares, com o trabalho e com outras atividades, uso de medicação de resgate, exacerbações, avaliação pessoal do nível de controle e de função pulmonar. Quando possível, a avaliação da função pulmonar, aliada a parâmetros clínicos (história e exame físico) fornecem a primeira indicação da piora da asma e permitem intervenções terapêuticas precoces, que no final podem levar a menos exacerbações e menos necessidade de esteróides sistêmicos e inalados. Finalmente, o manejo ideal da asma envolve atenção nas queixas do paciente (sintomas), que servirão como parâmetro de controle da asma, além da prescrição de medicamentos apropriados, em doses individualizadas, de acordo com a gravidade do caso. Palavras-chave: Asma, criança, guias de tratamento, controle.
Neuromuscular essentials : applying the preferred physical therapist practice patterns

Neuromuscular Essentials: Applying the Preferred Physical Therapist Practice PatternsSM answers the call to what today's physical therapy students and clinicians are looking for when integrating the Guide to Physical Therapist Practice as it relates to the neuromuscular system in clinical care. As a part of the Essentials in Physical Therapy led by Series Editor Dr. Marilyn Moffat, Neuromuscular Essentials: Applying the Preferred Physical Therapist Practice PatternsSM is edited by Joanell Bohmert in a user-friendly format that not only brings together the conceptual frameworks of the Guide language, but also parallels the patterns of the Guide. In each case, where appropriate, a brief review of the pertinent anatomy, physiology, pathology, pharmacology, and imaging is provided. Each pattern then details one to five diversified case studies coinciding with the Guide format. The physical therapist examination, including history, systems review, and specific tests and measures for each case, as well as evaluation, diagnosis, prognosis, plan of care, and evidence-based interventions are also addressed.