Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of radiotherapy in non-small-cell lung cancer.

The 5-year overall survival in patients with stage I NSCLC after surgery is around 67% for T1N0M0 tumors and 57% for T2N0M0 tumors [1]. Significant co-morbidity in these patients can render them medically inoperable [2]. Untreated earlystage lung cancer has a poor outcome, with the majority of patients dying of lung cancer in the 5-year period following diagnosis [3, 4]. Outcomes after conventional radiotherapy are modest, with a literature review reporting 3- and 5-year disease-specific survivals of 39±10% and 25±9%, and overall survival around 34±9% and 21±8%, respectively [5]. Reasons for the poorer survival after conventional radiotherapy in comparison with surgery include suboptimal staging of patients, insufficiently high radiation doses and ‘geographical misses’ owing to tumor mobility. Far superior local control rates have been reported with the use of hypofractionated extracranial stereotactic radiotherapy in stage I NSCLC, ranging from 85‐95% for T1N0 lesions [6‐8]. The high local control rates can be accounted for by the use of very high radiation doses (e.g. three fractions of 20Gy) delivered with careful attention paid towards accurate positioning of patients, individualized assessment of tumor mobility, non-coplanar radiation beam arrangements (Figure 1) and short overall treatment times. Despite the delivery of biologically effective doses of up to 180Gy [9], symptomatic radiation pneumonitis is observed in <5% of patients. While long-term follow-up data are awaited to confirm the low incidence of late radiation toxicity, stereotactic radiotherapy appears to be an effective alternative to surgery in high-risk patients with stage I NSCLC.
Ovarian Cancer Stem Cell–Like Side Populations Are Enriched Following Chemotherapy and Overexpress EZH2

Platinum-based chemotherapy, with cytoreductive surgery, is the cornerstone of treatment of advanced ovarian cancer; however, acquired drug resistance is a major clinical obstacle. It has been proposed that subpopulations of tumor cells with stem cell–like properties, such as so-called side populations (SP) that overexpress ABC drug transporters, can sustain the growth of drug-resistant tumor cells, leading to tumor recurrence following chemotherapy. The histone methyltransferase EZH2 is a key component of the polycomb-repressive complex 2 required for maintenance of a stem cell state, and overexpression has been implicated in drug resistance and shorter survival of ovarian cancer patients. We observed higher percentage SP in ascites from patients that have relapsed following chemotherapy compared with chemonaive patients, consistent with selection for this subpopulation during platinum-based chemotherapy. Furthermore, ABCB1 (P-glycoprotein) and EZH2 are consistently overexpressed in SP compared with non-SP from patients' tumor cells. The siRNA knockdown of EZH2 leads to loss of SP in ovarian tumor models, reduced anchorage-independent growth, and reduced tumor growth in vivo. Together, these data support a key role for EZH2 in the maintenance of a drug-resistant, tumor-sustaining subpopulation of cells in ovarian cancers undergoing chemotherapy. As such, EZH2 is an important target for anticancer drug development. Mol Cancer Ther; 10(2); 325–35. ©2010 AACR.
Scale-out evaluation of news feed retrieval algorithms on Neo4j and Titan clusters Bachelorarbeit

News feed platforms, such as Facebook and Twitter, are growing continuously. Their primary requirements are scalability, low request latencies and high availability [7] for read and write requests. This requires to scale out the system to multiple machines [10]. STOU and Graphity were reported as high performant algorithms to power a news feed system. However, their evaluation took place on a single machine with one thread, the algorithms didn’t support to run in a distributed system. We identified a proper experimental setup for the evaluation of scale-out. We implemented versions of STOU and Graphity, that support a distributed execution. We evaluated the news feed algorithms on two distributed graph databases, that use different distribution strategies: a) Neo4j with its database replication and b) Titan using Cassandra, that bases upon distributed hash-tables. Cassandra is an eventually-consistent database. Neo4j shows good read scale-out properties, for both STOU and Graphity, but its database replication approach can’t provide write scaleout. On Titan Graphity provides better read scale-out than STOU, while STOU shows good write scale-out properties. We weren’t able to implement Graphity in a manner, that would support concurrent writes in a distributed system. Graphity seems too complex, to be used on eventually-consistent databases. With caching enabled, its read performance is similar to STOU, while its runtime complexity for writes is higher. We conclude that STOU is more suitable to run in a distributed system. Both distribution strategies have strengths that can be used to power a news feed system and a combination of both approaches will show the better scale-out properties.
Who’s to Blame? Partisanship, Responsibility, and Support for Mental Health Treatment

This article investigates partisan beliefs regarding attributions of responsibility for mental illness and support for mental health treatment. In study 1, we utilize a nationally representative data set to investigate these relationships with respect to generalized anxiety disorder. In study 2, we utilize an online convenience sample to assess these relationships in the context of schizophrenia. In both studies, Republicans were more likely than Democrats to attribute mental health disorders to factors that lie within patients’ control and were less supportive of healthcare coverage. In addition, given the rhetorical, erroneous link between schizophrenia and gun violence, we assess participants’ beliefs about gun control in the context of mental health. Paradoxically, we find that people who support gun rights for the mentally ill are the least likely to support healthcare coverage for the mentally ill. We discuss the implications of our findings for shaping U.S. gun debates.
Orthogonal decode and forward relaying with improved spectral efficiency

Cooperative relay communications can significantly improve the reliability of data transmission over wireless fading channels by implementing spatial diversity in a distributed fashion. Orthogonal decode and forward (ODF) relaying achieves maximum diversity provided by the source-destination and relay destination channels, but suffers from low spectral efficiency. We propose a novel ODF protocol having higher spectral efficiency without sacrificing the diversity gain. We analyze the symbol error probability of the proposed protocol and also present simulation results.
L’INTRODUCTION D’UNE COMPTABILITE GENERALE AU SEIN DES CENTRES HOSPITALO-UNIVERSITAIRES (CHU) AU MAROC : CARACTERISTIQUES ET ANALYSE DES FACTEURS DE SUCCES

Selon (Bartoli, 2005), la comptabilite privee possede depuis longtemps un caractere complet que la comptabilite publique ne possede pas encore. Aussi la comptabilite publique n’a-t-elle longtemps ete qu’une comptabilite de caisse. Le systeme de gestion financiere publique est toujours caracterise de centralise de lourd, et d’inadapte. L’enjeu economique de recherches de recettes ou de sources de financement nouvelles selon plusieurs auteurs, (Allison, 1987; Bozec, 2004; Bozeman, 1987; Gibert, 2002; Parenteau, 1992; Thoening, 2000), represente une cause principale justifiant l’inadaptation de la comptabilite generale ou tout autres outils de gestion privee dans un contexte public. Cependant, la tenue de la comptabilite generale et la comptabilite analytique au lieu de la comptabilite publique peut contribuer a un meilleur controle de la gestion de l’entite publique. Ainsi, la plupart des innovations en SI incluent et les technologies d’information et les methodes de gestion administrative, mais pas necessairement dans les memes proportions. En effet, certaines innovations ont plus d’aspects technologiques (implantation d’une base de donnees), tandis que d’autres au contraire, ont plus d’impact sur le travail administratif (implantation d’un systeme de planification strategique). Plusieurs constats ont mis en evidence la trop lente diffusion des outils modernes de gestion dans les organisations publiques malgre leurs avantages par rapport aux outils traditionnelles. Dans cette communication, nous avons tente d’apporter de nouveaux elements de reponse a ce paradoxe, en examinant le volet de diffusion des outils de la comptabilite generale et puis le volet du succes ou de blocage dans son implantation. Nous avons donc construit un modele theorique global qui porte sur les facteurs de succes ou blocage d’implantation des outils modernes de la gestion comptable dans les etablissements publics a caractere administratif, a partir d’une analyse des apports theoriques et les resultats de notre enquete empirique.
KIF 14 and citron kinase act together to promote effi cient cytokinesis

Cytokinesis is the physical cell division process that follows the duplication and spatial segregation of the genetic material (Glotzer, 2005). In animal cells, a complex microtubule structure termed the central spindle or spindle midzone forms between the retreating chromosomes in anaphase and organizes many proteins essential for the process of cytokinesis (Glotzer, 2005). One of the critical components of this structure is the microtubule-associated protein (MAP) PRC1 (protein-regulating cytokinesis 1; Jiang et al., 1998; Mollinari et al., 2002; Kurasawa et al., 2004). PRC1 not only promotes the formation of stable microtubule bundles (Mollinari et al., 2002) but also acts as a scaffold for the kinesin-4 family chromokinesin KIF4 (Kurasawa et al., 2004; Miki et al., 2005). In PRC1-depleted
An FPGA-based test platform for analyzing data retention time distribution of DRAMs

Data retention time distribution of a dynamic random access memory (DRAM) has a heavy impact on its yield, power, and performance. Accurate and detailed information of data retention time distribution thus is very important for the DRAM designer and user. This paper proposes an FPGA-based test platform for analyzing the data retention time distribution of a DRAM. Based on the test platform, a test flow is also proposed to classify the DRAM cells with different data retention times with respect to different supply voltage and temperature. We have demonstrated the test platform and test flow using a Micron 2Gb DRAM.
Mining Customer Requirement from Helpful Online Reviews

Today there are a huge quantity of online reviews available across different categories of products. The key question is how to select helpful online reviews and what can we learn from the abundant reviews. In this paper, we first conclude five categories of features to predict reviews' helpfulness from the perspective of a product designer and then present an approach based on conjoint analysis to measure customer requirement. The suggested approach are demonstrated using product data from a popular Chinese mobile phone market.
Form registration: a computer vision approach

In this paper, a technique for extracting the distortion parameters in filled-in forms is presented. The technique determines the transformations that are required to convert a filled-in form to match a known master and then extracts filled-in information. The method involves determining corresponding lines and key points between the master and the filled-in form and using the correspondence to determine the appropriate transformation. The correspondence problem is solved using results from affine geometry.
A possible correlation between vestibular stimulation and auditory comprehension in children with attention-deficit/ hyperactivity disorder

Twenty children, aged 10 to 12 years with attention-deficit/hyperactivity disorder (ADHD), were selected to study the effect of vestibular stimulation on auditory perception and sensitivity using the Integrated Visual and Auditory Continuous Performance Test (IVA CPT; a neuropsychological test that is applied in occupational therapy clinics). The present study examined children based on the criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision. After obtaining guardian and parental consent, the children were enrolled in the study and randomly matched according to age across intervention and control groups. The IVA CPT was applied as a pre-test. The children in the intervention group then received vestibular stimulation during therapy sessions twice per week for 10 weeks. The IVA CPT assessment (post-test) was then applied in both groups. The mean pre- and post-test scores were compared across groups. The statistical analyses revealed a significant difference in improvement in auditory comprehension. In conclusion, the present findings suggest that vestibular training is a reliable and powerful treatment option for ADHD, especially when combined with other training. Stimulating the sense of balance highlights the important interaction between inhibition and cognition.
Effects of Hyperbaric Oxygen on Inflammatory Response to Wound and Trauma: Possible Mechanism of Action

There is growing interest in expanding the clinical applications for HBO2 (hyperbaric oxygen therapy) into new medical and surgical fields. The pathophysiology of response towards wounds, infection, trauma, or surgery involves various chemical mediators that include cytokines, prostaglandins (PGs), and nitric oxide (NO). The beneficial role played by HBO2 in wound healing, carbon monoxide poisoning, decompression sickness, and other indications is well documented. However, the exact mechanism of action is still poorly understood. This review addresses the effects of HBO2 on PGs, NO, and cytokines involved in wound pathophysiology and inflammation in particular. The results of this review indicate that HBO2 has important effects on the biology of cytokines and other mediators of inflammation. HBO2 causes cytokine down-regulation and growth factor up-regulation. HBO2 transiently suppresses stimulus-induced proinflammatory cytokine production and affects the liberation of TNFα (tumor necrosis factor alpha) and endothelins. VEGF (vascular endothelial growth factor) levels are significantly increased with HBO2, whereas the value of PGE2 and COX-2 mRNA are markedly reduced. The effect of HBO2 on NO production is not well established and more studies are required. In conclusion, cytokines, PGs, and NO may play a major role in the mechanism of action of HBO2 and further research could pave the way for new clinical applications for HBO2 to be established. It could be proposed that chronic wounds persist due to an uncontrolled pathological inflammatory response in the wound bed and that HBO2 enhances wound healing by damping pathological inflammation (anti-inflammatory effects); this hypothetical proposal remains to be substantiated with experimental results.
Intraoperative Dermatomal Evoked Potential Monitoring Fails to Predict Outcome From Lumbar Decompression Surgery

Study Design. Thirty‐three patients with single‐level, unilateral lumbosacral radiculopathy underwent microdecompression and intraoperative dermatomal evoked potential monitoring. Side‐to‐side latency asymmetry was calculated. A criteria for "abnormal" was defined. Intraoperative dermatomal evoked potentials were obtained before and after decompression. The changes were correlated with clinical outcome at the 3‐month follow‐up examination. Objectives. To determine whether intraoperative dermatomal evoked potential latency asymmetry confirms nerve root compression and whether an improvement of latency asymmetry after decompression predicts a good clinical outcome. Summary of Background Data. Intraoperative dermatomal evoked potential has been proposed as a test to assess the adequacy of nerve root decompression. Initial reports suggested improvement of dermatomal evoked potential amplitude and latency after decompression. The clinical efficacy is controversial because of its technical difficulty and inherent variation. Methods. Cervical recording was chosen to reduce the effects of anesthesia. The asymptomatic nerve root was used as a control. Quality of the tracings was determined by evoked potentials‐to‐noise amplitude ratio. Clinical outcome was based on patient's pain relief and satisfaction. Results. Tracings of acceptable quality were obtained at baseline in 57.6% (19 of 33) of patients. A side‐to‐side latency asymmetry > 5% was defined as abnormal. Before decompression, 68.4% (13 of 19) of patients had an abnormal dermatomal evoked potential. After decompression, latency asymmetry returned to normal in every patient. Clinical outcome was good or excellent in 13 patients, fair in four patients, and poor in two patients. Dermatomal evoked potential latency improvements were not related to variation in clinical outcome. Conclusions. Intraoperative dermatomal evoked potential monitoring is technically demanding. Finding reproducible potentials is difficult. More research is necessary before general use of dermatomal evoked potentials for monitoring nerve root decompression.
Comparative study on Wordlength Reduction and Truncation for low power multipliers

Power consumption in Digital Signal Processing systems directly relies on the precision of multipliers. As bigger bitwidths are desirable for achieving higher precisions, they result in bigger multipliers with high toggling profiles and higher power figures. In recent years some techniques that trade power for accuracy by removing or reconfiguring blocks of the multiplier have been made available. Choosing the correct technique and implementing it can make a big difference regarding power. This being specially important on low-power battery-operated devices, where a longer life could be preferred to a higher output precision. Operand Reduction and Truncated multipliers are two such techniques. They are reviewed in this paper and their effectiveness and power vs accuracy exchange profiles are compared and analyzed for ASIC design via simulation. Comparative results are presented after applying both techniques to a 16-bit Wallace tree-based multiplier synthesized in 90nm low power standard cells.
Client-centred home modifications improve daily activity performance of older adults

Background Remaining at home is a high priority for many older adults, but the capacity to “age in place” often is threatened by environmental barriers. Purpose To describe a client-centred occupational therapy home modification intervention program and examine the impact of the intervention on daily activity performance over time. Methods Using a competence-environmental press framework, a client-centred home modification program for older adults was implemented. In this quasi-experimental, single group prospective study, participants' subjective ratings of daily activity performance were evaluated before and after the intervention (baseline/post/post). Findings After home modification, participants' perception of their daily activity performance at home improved significantly and was maintained 2 years post-modification. Implications Home modification may benefit older adults attempting to age in place.
Step-stress accelerated degradation modeling based on nonlinear Wiener process

Aiming at nonlinear degradation data in step-stress accelerated degradation test (SSADT), the reliability assessment method is put forward based on Wiener process. the process and degradation data model of SSADT is analyzed. The time scale model is used to convert nonlinear data into linear data. Draft coefficient of Wiener process is regarded as a random variable. Reliability model for nonlinear degradation data is built in consideration of individual variation. The two-step maximum likelihood estimation method (TSMLE) is used to derive the unknown parameters. An example is analyzed to show that presented model is correct.
Walter Scott and the Islamic East: Ivanhoe and the Talisman

This paper examines representations of the Islamic East in two novels by Sir Walter Scott: Ivanhoe (1820) and The Talisman (1825). The paper’s argument is that Scott’s representations of the Islamic East seems influenced in very specific ways by dominant nineteenth-century portrayals of the East. Scott’s two novels present ambivalent depictions of the East, some of which deviate from standard patterns of representation of earlier centuries. For instance, on the one hand his novels attribute positive spiritual qualities to Saracens such as generosity, bravery and kindness to animals, while on the other, and often in the same passage, they sometimes depict Saracens as violent and atavistic. I argue that, through his various narrators and characters, Scott depicts the relationship between the Islamic East and the Christian West as a significant form of cultural interaction whereby the East is presented as complementing the West. However, Scott’s portrayal of East-West relation is complex, and it would be inaccurate to claim that this denotes total acceptance of Islamic manners, customs and perspectives.
Current concepts in laceration repair

Lacerations account for a significant number of emergency department and urgent care clinic visits for pediatric patients. Children represent a unique challenge in repairing lacerations because of their developmental and behavioral characteristics, making rapidity, ease of performance, and minimal pain particularly desirable. This review focuses on three concepts in laceration repair where there have been significant advances in the past several years in terms of new techniques and drugs. New pharmacologic modalities such as the fentanyl oralet for sedation of children are discussed as well as important nonpharmacological techniques such as parental presence. Topical administration of anesthetics such as tetracaine, adrenaline, and cocaine and lidocaine, epinephrine, and tetracaine offers the advantage of replacing lidocaine infiltration and provides an effective, safe, and painless alternative for local anesthesia. Finally, the introduction of cyanoacrylate tissues adhesives such as Histoacryl Blue (Trihawk International, Montreal, Canada) and Dermabond (Ethicon, Somerville, NJ) appear to be an ideal technique for laceration closure in children because they are easy and rapid to apply, are relatively painless, eliminate the need for suture removal, and provide an acceptable cosmetic result.