Miracle-dz/UniFAR-FTUs huggingface dataset:
Distinct Effects of Recombinant Tenascin‐R Domains in Neuronal Cell Functions and Identification of the Domain Interacting with the Neuronal Recognition Molecule F3/11

We have identified distinct domains of the rat extracellular matrix glycoprotein tenascin‐R using recombinant fragments of the molecule that confer neuronal cell functions. In short‐term adhesion assays (0.5 h), cerebellar neurons adhered best to the fragment representing the fibrinogen knob (FG), but also the fibronectin type Ill (FN) repeats 1‐2 and 6‐8. FG, FN1‐2 and FN3‐5 were the most repellent fragments for neuronal cell bodies. Neurites and growth cones were strongly repelled from areas coated with fragments containing the cysteine‐rich stretch and the EGF‐like domains (EGF‐L), FN1‐2, FN3‐5 and FG. Polarization of morphology of hippocampal neurons was exclusively associated with FG, while EGF‐L prevented neurite outgrowth altogether. The binding site of the neuronal receptor for tenascin‐R, the immunoglobulin superfamily adhesion molecule F3/11, was localized to EGF‐L. The combined observations show distinct, but also overlapping functions for the different tenascin‐R domains. They further suggest the existence of multiple neuronal tenascin‐R receptors which influence the response of neurons to their extracellular matrix environment.
A comparison of speed-sensorless induction motor control with torque compensation

This paper compares two indirect field oriented control approaches of speed sensorless MRAS schemes. The first scheme is a feedback linearization control of an induction motor including proportional integral compensation. The second is a modify feedback linearization scheme, where the current control is composed only by proportional integral controllers. Experimental analyses of the feedback linearization control demonstrate that it requires a larger computation effort as well as it has high sensitivity to model parameters variation. In order to overcome these limitations, this paper proposes a modified scheme based on two PI controllers to generate the stator drive voltage. Simulation and experimental results, in DSP TMS 320F2812 based platform, are provided to evaluate both control schemes performance.
In situ use of suicide genes for cancer therapy.

Gene therapy has now become a standard experimental approach for treating cancers that have failed conventional therapies. As the understanding of the molecular nature of carcinogenesis develops, new approaches are being taken to directly target tumor cells, thus bypassing the difficulties of killing cells that are resistant to chemotherapy and radiation. One emerging gene therapy approach has been through the genetic modification of tumor cells with a suicide gene such as the herpes simplex virus thymidine kinase gene (HSV-TK) and ganciclovir (GCV) therapy. Death of tumor cells modified with the HSV-TK gene leads to killing of unmodified in situ tumor cells in a phenomenon termed the "bystander effect. " The basis both for this effect and other gene therapy trials underway for the treatment of cancer will be discussed.
ERK and mTOR Signaling Couple β-Adrenergic Receptors to Translation Initiation Machinery to Gate Induction of Protein Synthesis-dependent Long-term Potentiation*

β-Adrenergic receptors critically modulate long-lasting synaptic plasticity and long-term memory in the mammalian hippocampus. Persistent long-term potentiation of synaptic strength requires protein synthesis and has been correlated with some forms of hippocampal long-term memory. However, the intracellular processes that initiate protein synthesis downstream of the β-adrenergic receptor are unidentified. Here we report that activation of β-adrenergic receptors recruits ERK and mammalian target of rapamycin signaling to facilitate long-term potentiation maintenance at the level of translation initiation. Treatment of mouse hippocampal slices with a β-adrenergic receptor agonist results in activation of eukaryotic initiation factor 4E and the eukaryotic initiation factor 4E kinase Mnk1, along with inhibition of the translation repressor 4E-BP. This coordinated activation of translation machinery requires concomitant ERK and mammalian target of rapamycin signaling. Taken together, our data identify distinct signaling pathways that converge to regulate β-adrenergic receptor-dependent protein synthesis during long-term synaptic potentiation in the hippocampus. We suggest that β-adrenergic receptors play a crucial role in gating the induction of long-lasting synaptic plasticity at the level of translation initiation, a mechanism that may underlie the ability of these receptors to influence the formation of long-lasting memories.
Huffman Coding based Adaptive Pixel Pair Matching Steganography for Audio files

Information Hiding is the process of securing data over covert channel. Cryptography and Steganography are two main techniques for accomplishing security. Steganography is the process of concealing secret data within cover media. Substitution techniques like Least Significant Bit Substitution (LSB) and Optimum Pixel Adjustment Process (OPAP) uses one pixel for concealing the secret digit. Pixel Pair Matching (PPM) uses two pixel pairs for accomplishing data hiding. Two variants of PPM are Exploiting Modification Direction (EMD) and Diamond Encoding (DE). PPM achieves better Embedding Capacity than the previous methods. Improved variant of DE is Adaptive Pixel Pair Matching (APPM) where the extraction function is modified than that of the existing PPM techniques to improve the payload capacity and to minimize the Peak Signal to Noise Ratio (PSNR). In this paper, the secret message is first Huffman encoded and then undergoes the existing APPM technique. Huffman Encoding depends on the probability of occurrence of pixel values. It is a kind of lossless compression algorithm. It tends to improve the data embedding capacity. APPM technique employs two pixel values (a, b) and (a’, b’) where one is used as reference coordinate and the other is used as search co-ordinate. Depending on the coded secret value, the extraction function is employed to conceal the pixel.
[P50 sensory gating studies in schizophrenics: a systematic review].

OBJECTIVE To conduct a systematic review of P50 sensory gating studies in schizophrenics and the change between before and after treatment. METHODS Standard search strategy for the Cochrane Review Group was performed by two review authors. Searches were made in PubMed, EMBase, Web of knowledge, PsycINFO, Cochrane Library, CNKI, Wanfang, VIP and CBMDisc databases. STROBE (strengthening the reporting of observational studies in epidemiology) was used to assess the methodological quality of the studies. RevMan 5.0. 23 software was employed to conduct a Meta analysis. RESULTS Seventy-one literatures were reviewed and 7 studies met the inclusion criteria for a Meta analysis. The meta-analysis of random effects showed that S1 amplitude was lower in the schizophrenia group than in the normal control group (P = 0.02). And S2 amplitude was significant higher in schizophrenia group than the normal control group (P = 0.001). There were no statistical significance in S1 and S2 latency between two groups (P = 0.34 and P = 0.19 respectively). P50 Ratio in schizophrenia group was significantly higher than the normal control group. And the difference was statistically significant [Z = 11.46, P < 0.00001, combined SMD = 44.18, 95%CI (36.62, 51.74)]. However the P50 difference showed no significant difference (P = 0.14). An analysis of fixed effects showed that the P50 Ratio difference was not statistically significant in schizophrenics between before and after treatment (P = 0.19). CONCLUSION The schizophrenics have a sensory gating dysfunction. P50 Ratio is a stable and reliable indicator of sensory gating function. Antipsychotics may partly enhance P50 sensory gating in schizophrenics, but can not completely reverse the defect of P50 suppression.
SOME METHODOLOGICAL ASPECTS IN THE PSYCHOSOMATIC GYNAECOLOGY

Abstract. Psychosomatic medicine—and thus psychosomatic gynaecology—is presented as an approach to be used by doctors when meeting the patient. At the same time it is a method, a technique, trying to elucidate the mechanisms in the most complicated interplay between the psychological, somatic and social “parts of the whole”. Some diagnostic methods which can be used in this connection are discussed. The basic aim of the paper is to show the necessity and the possibility for the gynaecologist to use new technique from the psychodiagnostic field in his daily practice in order to achieve a better understanding of his patienťs complaints and needs.
Multi-channel measurement of RF complex refractive index by live electrooptic imaging camera

The concept of multi-channel RF complex refractive index measurement using a live electrooptic imaging (LEI) camera is proposed. The complex refractive index of water has been successfully evaluated with the transmitted microwave intensity and phase information being acquired within 0.5 s in a parallel manner suggesting that the instantaneous observation functionality of the LEI camera could be beneficial for prompt diagnosis and analysis of time-varying samples. The obtained refractive indices coincide well with those reported in the literature.
Boosted subunits: a framework for recognising sign language from videos

This study addresses the problem of vision-based sign language recognition, which is to translate signs to English. The authors propose a fully automatic system that starts with breaking up signs into manageable subunits. A variety of spatiotemporal descriptors are extracted to form a feature vector for each subunit. Based on the obtained features, subunits are clustered to yield codebooks. A boosting algorithm is then applied to learn a subset of weak classifiers representing discriminative combinations of features and subunits, and to combine them into a strong classifier for each sign. A joint learning strategy is also adopted to share subunits across sign classes, which leads to a more efficient classification. Experimental results on real-world hand gesture videos demonstrate the proposed approach is promising to build an effective and scalable system.
Sparse Localized Decomposition of Deformation Gradients

Sparse localized decomposition is a useful technique to extract meaningful deformation components out of a training set of mesh data. However, existing methods cannot capture large rotational motion in the given mesh dataset. In this paper we present a new decomposition technique based on deformation gradients. Given a mesh dataset, the deformation gradient field is extracted, and decomposed into two groups: rotation field and stretching field, through polar decomposition. These two groups of deformation information are further processed through the sparse localized decomposition into the desired components. These sparse localized components can be linearly combined to form a meaningful deformation gradient field, and can be used to reconstruct the mesh through a least squares optimization step. Our experiments show that the proposed method addresses the rotation problem associated with traditional deformation decomposition techniques, making it suitable to handle not only stretched deformations, but also articulated motions that involve large rotations.
Rim, a Component of the Presynaptic Active Zone and Modulator of Exocytosis, Binds 14-3-3 through Its N Terminus*

Rim1, a brain-specific Rab3a-binding protein, localizes to the presynaptic cytomatrix and plays an important role in synaptic transmission and synaptic plasticity. Rim2, a homologous protein, is more ubiquitously expressed and is found in neuroendocrine cells as well as in brain. Both Rim1 and Rim2 contain multiple domains, including an N-terminal zinc finger, which in Rim1 strongly enhances secretion in chromaffin and PC12 cells. The yeast two-hybrid technique identified 14-3-3 proteins as ligands of the N-terminal domain. In vitro protein binding experiments confirmed a high-affinity interaction between the N terminus of Rim1 and 14-3-3. The N-terminal domain of Rim2 also bound 14-3-3. The binding domains were localized to a short segment just C-terminal to the zinc finger. 14-3-3 proteins bind to specific phosphoserine residues. Alkaline phosphatase treatment of N-terminal domains of Rim1 and Rim2 almost completely inhibited the binding of 14-3-3. Two serine residues in Rim1 (Ser-241 and Ser-287) and one serine residue in Rim2 (Ser-335) were required for 14-3-3 binding. Incubation with Ca2+/calmodulin-dependent protein kinase II greatly stimulated the interaction of recombinant N-terminal Rim but not the S241/287A mutant with 14-3-3, again indicating the importance of the phosphorylation of these residues for the binding. Rabphilin3, another Rab3a effector, also bound 14-3-3. Serine-to-alanine mutations identified Ser-274 as the likely phosphorylated residue to which 14-3-3 binds. Because the phosphorylation of this residue had been shown to be stimulated upon depolarization in brain slices, the interaction of 14-3-3 with Rabphilin3 may be important in the dynamic function of central nervous system neurons.
Cell survival and X-ray-induced DNA degradation in Micrococcus radiodurans.

Survival curves after x-irradiation of Micrococcus radiodurans were done by micromanipulation in a manner so that each colony-forming unit was visually accounted for. A measure of the survival of single cells was obtained by microdissection after the first post-irradiation division and reinoculation of the progeny cells. More than 90% of the cells (distinguished from colony-forming units) formed colonies after 600 krads. Irradiated cells and their progeny gave rise to a significant number of microcolonies which were distinguished by very slow growth rates. About 90% of lethally irradiated cells underwent between one and six divisions after which death and lysis of all the progeny occurred. This suggests that radiation-induced damage in some form persisted in the progeny of irradiated cells. Further evidence of persistent radiation-induced damage was found in the decreased survival of the first generation progeny of irradiated cells. Complete survival follows radiation doses which are associated with the d.
Tax Debt Enforcement: Theory and Evidence from a Field Experiment in the United States

We present theory and evidence about the enforcement of tax delinquencies, which are tax debts incurred with the government. In our model, the tax agency relies on a financial penalty and a social penalty that involves publishing the names of tax delinquents online, a policy that is becoming increasingly common. We show that, when the tax agency cares about social welfare as well as revenues, the optimal policy involves a mix of financial and social penalties. We conducted a field experiment with 35,000 tax delinquents who owed half a billion dollars in three U.S. states. We find that increasing the salience of both financial and social penalties reduces tax delinquencies. We also provide suggestive evidence that, as predicted by our model, the effectiveness of social and financial penalties depends on the debtor's income garnishability.
Does the Source of Laser Energy Influence the Coagulation of Chorionic Plate Vessels? Comparison of Nd:YAG and Diode Laser on an ex vivo Placental Model

Objectives: To compare the histological effects of diode and Neodymium-Yttrium Aluminium Garnet (Nd:YAG) laser coagulation of chorionic plate vessels. Methods: In selected chorionic plate vessels in an ex vivo term placenta perfused with warm saline solution, diode (wavelength 940 nm) and Nd:YAG (wave length 1,064 nm) laser were used with an output of 30, 40, and 50 W, and 55 and 70 W respectively using preset energy and duration of impact. All vessels were examined histologically blindly to the procedures’ characteristics. Results: A total of 23 vessels were coagulated. Similar histological lesions were observed using diode and Nd:YAG lasers. The lesions were compatible with an acceptable clinical effect at all power outputs tested. The results were not related to the diameter or type of vessels. Lesions of the endothelium and reduction of the vessel lumen were best achieved with a diode laser at 40 W. Conclusion: Nd:YAG and Diode laser induce significant and comparable changes in chorionic plate vessels compatible with an efficient coagulation process under the experimental condition used.
Avaliação da síntese de nanopartículas de prata sob diferentes concentrações do extrato de Copaíba multijuga(Heine)

As nanoparticulas, em especial as nanoparticulas de prata NPs-Ag, estao sendo empregadas hoje em diversas aplicacoes tecnologicas, como por exemplo, no campo da informatica, medicina, biotecnologia entre outros. As NPs-Ag possuem propriedades fisico-quimicas muito caracteristicas, incluindo a sua flexibilidade, maleabilidade e uma condutividade termica e eletrica elevada em relacao a qualquer outro metal, alem da sua estabilidade quimica, atividade catalitica e um comportamento otico nao linear. As nanoparticulas de prata foram feitas a partir do metodo de sintese verde, utilizando extratos de plantas, respectivamente a copaiba como agente redutor, as concentracoes utilizadas foram de 100µg/mL, 150 µg/mL, 200 µg/mL, 250 µg/mL e 300 µg/mL.Para obtencao das nanoparticulas de prata foi utilizada uma solucao padrao de nitrato de prata e como agente redutor foram utilizados diferentes concentracoes de extrato de copaiba. A caracterizacao das Nps-Ag foram feitas por espectroscopia Uv-Vis e as leituras do tamanho e da distribuicao do tamanho das nanoparticulas nos coloides foram realizadas pela tecnica de espalhamento dinâmico de luz – DLS que avalia o raio hidrodinâmico, utilizando um sistema zetasizer Nano ZS90 (Malvern Instruments, UK). A sintese de nanoparticulas de prata utilizando o extrato aquoso das folhas de Copaiba multijuga promove uma abordagem mais amigavel ao meio ambiente, simples, eficiente e com baixo custo para a obtencao de nanoparticulas, pois dispensa o uso de estabilizadores ou agentes redutores externos
Response to Patient‐Initiated Plant Extract Treatment for Atopic Dermatitis

Ethnomedical practices are increasing in all parts of the world, including many urban centers. We describe a unique case of a 7‐year‐old girl with atopic dermatitis who was responsive to parent‐initiated treatment with the extract of a plant from the Chenopodium genus. A brief discussion raises awareness of such practices to the practicing dermatologist.
April 1994 EDO-CG-94-05 Counselor Intentionality and Effective Helping

The counseling profession has historically searched for characteristics, traits, behaviors, and other variables that contribute to successful helping relationships. One characteristic that emerges in contemporary literature and research relates to the notion that successful counselors select their helping behaviors and choose specific strategies with a clear purpose and direction. This characteristic is referred to as counselor’s level and degree of intentionality (Ivey, 1994; Purkey & Schmidt, 1987; Schmidt, 1984). Research indicates that effective counselors tend to exhibit positive perceptions of self and others, are personally motivated and fully functioning, accurately assess the world around them, and are capable of using this assessment to facilitate beneficial helping relationships (Schmidt, 1984).
The value architecture framework for success of ICT type projects

Critical Success Factors (CSFs) are essential factors that ensure success. CSFs must in some way be harnessed to ensure that the ICT type project is not handicapped from the start and is successful instead. In the research community, considerable research is dedicated to CSFs due to the number of ICT type project failures. The central issues of CSFs have not been solved. The intention of this paper is to present a new framework to better support ICT type projects, using three (3) CSFs. This framework begins at the core of the organisation, suitably changing the approach to projects beginning at the core business processes. The structure of the framework is conceptually suitable for organisations in different industrial sectors. The value architecture results in less CSFs and stimulates innovative thought around core business processes.
Characterization and Modeling of a Hybrid-Electric-Vehicle Lithium-Ion Battery Pack at Low Temperatures

Although lithium-ion batteries have penetrated hybrid electric vehicles (HEVs) and pure electric vehicles (EVs), they suffer from significant power capability losses and reduced energy at low temperatures. To evaluate those losses and to make an efficient design, good models are required for system simulation. Subzero battery operation involves nonclassical thermal behavior. Consequently, simple electrical models are not sufficient to predict bad performance or damage to systems involving batteries at subzero temperatures. This paper presents the development of an electrical and thermal model of an HEV lithium-ion battery pack. This model has been developed with MATLAB/Simulink to investigate the output characteristics of lithium-ion batteries over the selected operating range of currents and battery capacities. In addition, a thermal modeling method has been developed for this model so that it can predict the battery core and crust temperature by including the effect of internal resistance. First, various discharge tests on one cell are carried out, and then, cell's parameters and thermal characteristics are obtained. The single-cell model proposed is shown to be accurate by analyzing the simulation data and test results. Next, real working conditions tests are performed, and simulation calculations on one cell are presented. In the end, the simulation results of a battery pack under HEV driving cycle conditions show that the characteristics of the proposed model allow a good comparison with data from an actual lithium-ion battery pack used in an HEV.
Outer membrane vesicles – offensive weapons or good Samaritans?

Outer membrane vesicles (OMVs) from Gram-negative bacteria were first considered as artifacts and were followed with disbelief and bad reputation. Later, their existence was accepted and they became characterized as bacterial bombs, virulence bullets, and even decoys. Today, we know that OMVs also can be involved in cell–cell signaling/communication and be mediators of immune regulation and cause disease protection. Furthermore, OMVs represent a distinct bacterial secretion pathway selecting and protecting their cargo, and they can even be good Samaritans providing nutrients to the gut microbiota maintaining commensal homeostasis beneficial to the host. The versatility in functions of these nanostructures is remarkable and includes both defense and offense. The broad spectrum of usability does not stop with that, as it now seems that OMVs can be used as vaccines and adjuvants or vehicles engineered for drug treatment of emerging and new diseases not only caused by bacteria but also by virus. They may even represent new ways of selective drug treatment.