Miracle-dz/UniFAR-FTUs huggingface dataset:
Synergistic and antagonistic effects of immunomodulatory drugs on the action of 1 antifungals against Candida glabrata and Saccharomyces cerevisiae 2 3

20 Candidemia and other forms of invasive candidiasis caused by Candida glabrata and to a lesser 21 extent Saccharomyces cerevisiae are a serious health problem, especially if their steadily rising 22 resistance to the limited range of antifungal drugs is taken into consideration. Various drug 23 combinations are an attractive solution to the resistance problem, and some drug combinations 24 are already common in the clinical environment due to the nature of diseases or therapies. We 25 tested a few of the common antifungal-immunomodulatory drug combinations and evaluated 26 their effect on selected strains of C. glabrata and S. cerevisiae. The combinations were 27 performed using the checkerboard microdilution assay and interpreted using the Loewe 28 additivity model and a model based on the Bliss independence criterion. A synergistic 29 interaction was confirmed between calcineurin inhibitors (Fk506 and cyclosporine A) and 30 antifungals (fluconazole, itraconazole, and amphotericin B). A new antagonistic interaction 31 between mycophenolic acid (MPA) and azole antifungals was discovered in non-resistant 32 strains. A possible mechanism that explains this is induction of the Cdr1 efflux pump by MPA 33 in C. glabrata ATCC 2001. The Pdr1 regulatory cascade plays a role in overall resistance to 34 fluconazole, but it is not essential for the antagonistic interaction. This was confirmed by the 35 Cgpdr1D mutant still displaying the antagonistic interaction between the drugs, although at 36 lower concentrations of FLC. This antagonism calls into question the use of simultaneous 37 therapy with MPA and azoles in the clinical environment. 38 39 Introduction 40 The frequency and associated mortality of candidemia and other forms of invasive 41 candidiasis have not decreased over the past two decades despite the introduction of several 42 extended-spectrum triazole and echinocandin antifungal drugs for use in prophylaxis, empiric 43 therapy, and targeted therapy (Pfaller & Diekema, 2007; Pfaller & Castanheira, 2016). Candida 44 Commented [DC1]: Saccharomyces does not cause candidemia rewrite
Image Based Panorama Representation for Immersive Projection Display System

The immersion is the key feature of the CAVE system of virtual reality. If we surround users by the real images panoramic imaging in CAVE, we can make more realistic environment. We make the panoramic images from the real environment using a digital camera and a panoramic tripod head and apply them to the K-CAVE system to increase user's immersion. We formulate panoramic image photographing for efficiency and use the SCTP data connection for reliability in the K-CAVE system.
Meeting in the agora: a description logic approach to peer-to-peer e-commerce

We propose a logical approach to supply-demand matching in peer-to-peer e-commerce, where demand and supply are both described as concepts to be matched, either completely -full match- or partially -partial match- as it allows for an open-world assumption. Incomplete information can be dealt with, and absence of information can be distinguished from negative information, allowing one to discard offers/requests without the necessary properties, and to ask for missing information in the potential matches. The logical approach has been deployed in a prototype system implemented for a particular ontology but easily generalizable. Limits and possibilities of the proposed approach are analyzed and discussed.
The Main Approaches of Studying the Mechanisms of Action of Artificial Electromagnetic Fields on Cell

The effects of Electromagnetic Fields (EMFs) on health are discussed. These effects produce public interest to biological action of EMFs. The cell effects of EMFs have to be investigated to understand the mechanism of the biological action of EMFs. Among such mechanisms three main points are discussed: EMF action on cell membranes; EMF action on free radical concentration in cell; the action of EMF on intracellular regulatory systems. The analysis of experimental results proves the multilateral nature of the impact of EMFs on cell.
A Multiscale Haemorheological Computer-Based Model of Atherosclerosis: An In-Depth Investigation of Erythrocytes-Driven Flow Characteristics in Atheroma Development

The mortality caused by cardiovascular diseases is dramatically increasing [1-4]. Atherosclerosis is among the main contributors to this extremely high cardiovascular disease mortality [1]. Atherosclerosis is controlled by mechanical forces exerted by the flow of blood on the inner lining of arteries, the endothelium [5-9]. In order to fight this lethal disease a realistic computational model is required that offers an accurate understanding of the effect of blood flow on the arterial wall. In order to realistically describe complex blood flow patterns and their interaction with the arterial wall, we have developed an integrated computational technique that takes into account both the particulate cellular composition of the blood and the interactions between the particulate blood and the vessel wall, in macro-circulation. The cellular composition of the blood was modelled using a multiphase fluid dynamics method by computing both an Eulerian fluid domain for modelling blood plasma, and a Lagrangian solid domain that represented the blood cells. Interactions of the blood with the vessel wall were realistically modelled using a novel iterative immersed boundary method. Both the multiphase technique and the immersed boundary method were validated by comparing obtained numerical results with the literature [10-1], and a high degree of similarity was found. Moreover, our multiscale integrated model was applied to characterize clinically relevant flow patterns from atherosclerotic arterial segments. Our model revealed that under realistic non- Newtonian multiphase cellcontaining blood flow conditions, the pressure at the stenosis site is c. 30% higher than predicted by single-phase Newtonian fluid dynamics models [10,12]. This effect is most probably explained by a decrease of c. 28% in the peak velocity. The latest seems to be caused by the momentum interchange due to the collision of the particles (blood cells) with each other, with the vessel wall, and with the fluid phase (plasma). The most significant difference in velocities between the single-phase and the two-phase results was registered at the stenosis site. It was also found that high blood cell content (peak particle concentration) correlates with increasing flow laminarization. This means a decrease in velocity, which is more evidenced at the site of the stenosis. Additionally, our findings indicated that wakes forming downstream of the stenosis might be much weaker in non-Newtonian blood flow simulations compared to the Newtonian models. Taken together, our mathematical model and the resulting computational results might offer a more accurate understanding of the effects of realistic blood flow patterns on atherosclerotic vessels. This is of crucial importance since this deadly disease is initiated and progressed by blood flow related mechanical factors, such as the wall shear stress [8-9,22-25].
Report on the Psychology and Sociology of the Todas and other Indian Tribes

Six months were spent in India, the greater part of the time being devoted to the investigation of the Todas of the Nilgiri Hills. The senses of these people were examined experimentally on the same lines as those followed by the Cambridge Expedition to Torres Straits. The general result was to confirm the chief conclusion of this expedition that there are no great differences between the senses of savage and civilised races. In pure sense-acuity little difference was found, and the observations lend no support to the view that the sense-acuity of savage or harbarous races is superior to that of civilised man, the apparent superiority in some cases being due to the training of observation in special directions. In two senses only is there distinct evidence of difference between Todas and Englishmen in sensory endowment. The Todas are distinctly less sensitive to pain than the average educate Englishman, and they show the same kind of deficiency in the colour-sense which has been found in other races of low culture, especially in the Papuan and the Egyptian peasant.
Software Reliability Prediction Based on Least Squares Estimation

Abstract Of the main interest in practical software testing would be the prediction of the number of detected faults in future rather than the estimation of the quantitative reliability function, which is defined as the probability that the software does not fail during a pre-specified time interval after release. In other words, practitioners wish to know the number of remaining faults and the saturated level of the cumulative number of faults, in order to control the software testing process. In not only such a situation but also the case where the likelihood information of statistical models is not fully available, the least squares estimation (LSE) may be simple but very useful in estimating model parameters. Hence, the LSE methods should be comprehensively studied in the context of software reliability engineering. In this paper we examine four LSE methods with application to the software reliability prediction. In real data analyses based on several software fault data, we show that LSE methods are still attractive in terms of goodness-of-fit performance and predictive performance in many cases. Also, we analyze the software reliability models with trend change point based on the LSE methods.
Real Time Motion Authoring of a 3D Avatar

A diverse number of avatars that express human motions are produced in the fields of film, computer games, and virtual reality. In order to simulate human motions realistically, data are collected through a sensor-based method such as motion capture and are organized into a database; motions are then generated on the basis of this database. Human body motions can be reproduced naturally through a vast amount of data, but complicated calculations are necessary to generate these motions, and thus, it is not easy to generate an interactive 3 dimensional (3D) avatar in real time. In order to generate the motions of a 3D mobile avatar in real time, in this study, we implement a dataset with an intuitive classification through pattern recognition and propose the mapping of various avatar motions using a flexible and adaptive hierarchical algorithm. For real time motion authoring, we use a support vector machine (SVM) to classify the types of motion pattern data input from magnetic, angular rate, gravity (MARG) sensor.
Optimizing offer sets based on user profiles

Personalization and recommendation systems are being increasingly utilized by ecommerce firms to provide personalized product of ferings to visitors at the firms’ web sites. Th ese systems o ften recommend, at ea ch i nteraction, multiple items (referred to as an o ffer set) that mig ht be o f interest to a visito r. Wh en making recommenda tions firms typ ically attemp t to maximize th eir expected payoffs from the offer set. This paper examines how a firm c an maximize its expected payoffs by leverag ing th e kn owledge o f t he profiles of visito rs to t heir site. We provide a methodology that accounts for the interactions among items in an offer set in order to d etermine the exp ected payoff. Identifying t he optimal o ffer set is a difficult p roblem wh en t he nu mber of candidate items to rec ommend is large. We develop an ef ficient heuristic for this problem, and show that it performs well for both small and large problem instances.
A Study of How Behavioural Finance Theory Applies to the Senior Management Decision-Making Process in M&A

The purpose of this study is to construct a multi-factor behavioural model which can be applied to the research of behavioural trends in senior managers’ decision-making processes in M&A. Based on the academic analysis of Shefrin, Greenspan and empirical observations, a multi-factor behavioural model was constructed, in which the major factors were determined as ‘confirmation bias’, ‘information availability’, ‘illusion of control’, ‘affect heuristics’, the ‘human factor’ and the ‘individual investor behavioural model’. The existence of these factors in the senior management decision-making process was tested empirically by carrying out semi-structured interviews with senior practitioners in the M&A industry. The multi-factor behavioural model was extended to include two new behavioural factors: ‘risk aversion’ and ‘personal legacy’. These factors were displayed by senior managers by their tendency to evaluate the effect of a potential deal on their own welfare before initiating any M&A transaction, and only then conducting a risk-return profile assessment. Corresponding author: Rasa Balsyte, Cass Business School, 106 Bunhill Row, London EC1Y 8TZ, United Kingdom. Telephone: +44 (0) 20 7040 5146. Facsimile: +44 (0) 20 7040 5168. Email: rasa.balsytte@gmail.com (Balsyte), S.Moeller@city.ac. uk (Moeller).
On the psychology and economics of antisocial personality

Center for Research in Experimental Economics and Political Decision Making (CREED), University of Amsterdam, 1018 WB, Amsterdam, The Netherlands; Amsterdam Brain and Cognition (ABC), University of Amsterdam, 1018 WB, Amsterdam, The Netherlands; Behavioral and Experimental Economics, The Tinbergen Institute, 1082 MS, Amsterdam, The Netherlands; Institute for Transport Planning and Systems (IVT), Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland; Institute of Psychology, Leiden University, 2333 AK, Leiden, The Netherlands; Jacobs Center for Productive Youth Development, University of Zurich, 8050 Zurich, Switzerland; and Department of Economics, University of Zurich, 8006 Zurich, Switzerland
Capacitive sensors for measuring the pressure between the foot and shoe

A test was conducted of a Hercules Orthoflex capacitive sensor used to measure pressure distribution under the foot for gait analysis and sensory substitution. Maximal nonlinearity for the sensor is 16%, and maximal hysteresis is 10% over the pressure range 0 to 1.3 MPa. Seven transducers in each shoe determine the distribution of pressure. <<ETX>>
Multivariate Analysis of Variance for High Energy Physics Software in Virtualized Environments

Victor Fernandez Albor1, Marcos Seco1, Victor Mendez Munoz2, Tomas Fernandez Pena3, Juan Saborido Silva1 and Ricardo Graciani Diaz4 1 Physics department, Santiago de Compostela University Av Ciencias sn, Santiago de Compostela, Spain E-mail: {victormanuel.fernandez,marcos.seco,juan.saborido}@usc.es 2 Computer Architecture and Operating Systems (CAOS),Universidad Autonoma de Barcelona E-mail: victor.mendez@uab.es 3 Research Center in Information Technologies (CiTIUS), Santiago de Compostela University Av Ciencias sn, Santiago de Compostela, Spain E-mail: tf.pena@usc.es 4 Departamento de Estructura y Constituyentes de la Materia,Barcelona University E-mail: Ricardo.graciani@ecm.ub. es
BioSurveillance and the Holy Grid - Does it Compute?

The Centers for Disease Control and Prevention currently use Base SAS® and SAS® BI (OLAP, Portal, WebReport Studio) for the BioSense Application. Despite all caveats, the search for technology silver bullets continues in every field. The concept of a grid of computing resources originated in the 1970’s, and has re-emerged in the 90’s and this century as computing power, networks and middleware capabilities advanced to support it. Grid computing can provide a powerful backbone for healthcare research issues. However, establishing a grid is not just a matter of clustering large numbers of disks or blade servers, nor is it a solution for every public health issue. Grid-like resource usage can enable systems not typically associated with massively parallelizable problems to achieve higher levels of availability and reliability. This presentation will review the basics of grid architecture (i.e. grid computing, grid storage, grid collaboration) and existing uses in public health (for example, caBIG™), potential future uses relative to biosurveillance systems such as BioSense, and the pros and cons of introducing grid models in this arena. This presentation will be based upon experience with BioSense, IDS and CRA from the CDC and both SAS® and BioSense's relevance to the move towards a federated model based on grid technology.
SELECTED LEAST SIGNIFICANT BIT APPROACH FOR HIDING INFORMATION INSIDE COLOR IMAGE STEGANOGRAPHY BY USING MAGIC SQUARE

Abstruct : The main goal of steganography is to hide the existence of any secret data from the eye of third party, so the resultant stego-image must appear normal and not suspicious after the impeding process. Stego-image must have an acceptable quality in comparison with its size. Moreover, its size has to be on the rate of the usual Internet images, because it is required to be sent by this medium. This work focuses on these problems, using a novel Selected Least Significant Bit method. Standard color images were used to hide the data. The proposed approach has been evaluated and the results had been analyzed. The obtained results showed clear enhancements on the impeding space considering previous related works.
A Fingerprint Matching Algorithm Based on Band-Limited Phase-Only Correlation

ユビキタス情報化社会において,セキュリティ は,最も重要なキーワードの 1つであり,信頼性が 高く,利便性に優れたシステムが必要とされてい る. 現在までによく用いられている認証方法は,パ スワード,PIN (Personal Identification Number), 鍵などのように記憶や所持を必要とするものであ る. そのため,「忘れる」,「盗まれる」,「なくす」 という危険性がある. これらの問題に対し,記憶 や所持が不要で,さらに時間がたっても変化する ことのない究極的な認証方法として,個人の身体 的・行動的特徴をそのまま認証情報として利用す るバイオメトリクスが注目されている. 個人認証 システムにおいて利用されるバイオメトリクスに は,指紋・網膜・虹彩・筆跡などがある. これらの 中で,指紋を用いた認証システムは,その利便性 より最も研究開発されている 1). 指紋を使った照合法には,指紋の流れ(隆線) が途切れる点(端点)や分岐する点(分岐点)を 利用する「特徴点を使った照合」2, 3, 4) と,指紋 画像を重ね合わせて類似度を調べる「相関を使っ た照合」5, 6)がある. 特徴点を使った照合は,状態 が悪く特徴点が抽出しづらい指紋に対して弱いが, 歪みに対して強いという特徴がある. 一方,相関 を使った照合は,歪みに弱いが,特徴点が抽出し づらいような状態の悪い指紋でも正確に照合でき るという特徴がある.
DEVELOPMENT AND IMPLEMENTATION OF A METHODOLOGY FOR THE STUDY OF VOLTAGE DIPS IN BOGOTA

This paper presents a methodology developed by the authors for the study of quality power, in particular voltage dips in industrial and commercial users. The methodology consists of several steps and is applied to Mosquera Substation in Bogotá D.C. From the application of the methodology gives a method of extracting information of power quality meters, it applies a methodology to classify the different industrial and commercial users, then it applies the Bollen methodology to obtain the amount, duration, magnitude and types of voltage dips, then it uses an alternative methodology based on wavelet transformed and it compares the results of both methods. Finally, it develops contour curves and it evaluates some immunity cases from customer equipment in the substation under study.
miR-1395 p inhibits aerobic glycolysis , cell proliferation , migration , and invasion in hepatocellular carcinoma via a reciprocal regulatory interaction with ETS 1

Cancer cells have metabolic features that allow them to preferentially metabolize glucose through aerobic glycolysis, providing them with a progression advantage. However, microRNA (miRNA) regulation of aerobic glycolysis in cancer cells has not been extensively investigated. We addressed this in the present study by examining the regulation of miR-1395p on aerobic glycolysis of hepatocellular carcinoma (HCC) using clinical specimens, HCC cells, and a mouse xenograft model. We found that overexpressing miR-139-5p restrained aerobic glycolysis, suppressing proliferation, migration, and invasion in HCC cells. miR-139-5p regulated hexokinase 1 (HK1) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) expression by directly targeting the transcription factor ETS1, which bound to the promoters of the HK1 and PFKFB3 genes. miR-139-5p-induced aerobic glycolysis, proliferation, migration, and invasion were reversed by ETS1 overexpression, while ETS1 silencing induced the expression of miR-139-5p via a post-transcriptional regulation mode involving Drosha. miR-139-5p expression was reduced in HCC compared to para-carcinoma tissue, which was confirmed in The Cancer Genome Atlas and GSE54751 HCC cohorts. Notably, the lower expression of mir-139 was correlated with worse prognosis. These outcomes indicate that reciprocal regulatory interactions between miR-139-5p and ETS1 modulate aerobic glycolysis, proliferation, and metastasis in HCC cells, suggesting new targets for HCC treatment.
Economic Development of Shale Gas Reservoirs via Optimal Design of Hydraulic Fracture Stages : An Efficient Evolutionary Multi-Objective Approach

Recently, due to a rapid decline in petroleum prices the industry experiences higher demand for fast optimization strategies in unconventional reservoir management to keep the projects profitable and produce commercial volumes of natural gas from shale plays. To achieve these objectives we propose to couple shale gas numerical reservoir simulation with advanced optimization techniques for optimal hydraulic fracture design and placement. Judicious application of this approach can yield higher shale gas reserve estimates and improved project revenue. In this paper we present our novel multi-objective evolutionary optimization framework that allows to place hydraulic fractures in presence of multiple economic and/or production objectives.
Development of transient fault management methodology

This paper presents the results of development studies to diagnostic and support to locate faults in distribution systems with recognition patterns using neural networks. It presents the developed methodology for input data processing for neural networks, as well as for fault type identification. In this methodology is necessary to get input data and were designed equipment prototypes to measure and transmit data's and voltage transducers. These equipments were installed in two feeders in the concession area of an electrical energy distribution company. The paper conclusion is that all results obtained indicate the suitability of neural networks to support transient fault management.
Conventional Mechanics And Self-Organizing Processes In the Arctic Pack

Mechanical processes in the Arctic ice pack result in fragmented sea ice cover, the regular geometry of which could be described in main features in terms of the conventional mechanics. However the size distribution of sea ice floes does not exhibit the random (poissonianlike) statistics and follows the power law typical for self-similar (fractal) structures. The experimental data collected at the Russian iceresearch camp “North Pole 35” established on the Arctic ice pack in 2008 evidence that the driving force of this scale-invariant patterning is the self-organized drift dynamics, which exhibits scaling properties both in the energy exchange with the environment and in the time distribution of mechanical events.
RESPONSE OF MULTIDRUG-RESISTANT PSEUDOMONAS AERUGINOSA STRAINS TO ACTION OF SYNTHETIC AMINO ACIDS AND PEPTIDES

The influence of synthetic amino acids and peptides on the growth of Pseudomonas aeruginosa multidrug resistant strains isolated from soil has been studied. All investigated strains were sensitive to (S)-β-[4-allyl-3-(furan-2-yl)-5-thioxo-1,2,4-triasol-1-yl]-α-alanine, (S)-β-[4-allyl-3-(2’-chlorophenyl)-5-thioxo1,2,4-triazol-1-yl]-α-alanine, dipeptide N-formyl-methionyl-(S)-β-[4-allyl-3-(2’-chlorophenyl)-5-thioxo-1,2,4-triasol-1-yl]-α-alanine and tripeptide alanyl-glycyl(S)-β-[4-allyl-3-(pyridin-4’-yl)-5-thioxo-1,2,4-triasol-1-yl]-α-alanine. Dipeptide alanyl-(S)-β-[4-allyl-3-(pyridin-4’-yl)-5-thioxo-1,2,4-triazol-1-yl]-α-alanine demonstrates the strongest effect on the growth of P. aeruginosa strains 9311 (resistant to beta-lactams) and 9211 (resistant to beta-lactams and chloramphenicol), but has no influence on the P. aeruginosa 5249 (resistant to all antibiotics used in this study).