Miracle-dz/UniFAR-FTUs huggingface dataset:
A Case of Solitary Mediastinal Metastasis of Hepatocellular Carcinoma

背景．肝細胞癌の孤立性縦隔転移は稀である．症例．症例は51歳，男性．多発肝細胞癌に対する肝動脈塞栓療法中に，前縦隔の結節影を指摘された．胸部CTやMRIで周囲への浸潤を認めず，非浸潤性胸腺腫の術前診断で，胸腔鏡下胸腺右葉切除術を施行した．Hep Par 1を含む免疫染色の結果，肝細胞癌の縦隔転移と診断した．3ヶ月後に腹部大動脈周囲のリンパ節が孤立性に腫大したため，縦隔転移も前横隔膜リンパ節への孤立性転移であったと診断した．術後18ヶ月の現在，UFTを内服しながら担癌生存中である．肝細胞癌の孤立性縦隔転移は極めて稀であり，本邦での報告は本例を含めても11例に過ぎない．この11例中，局所のコントロールが良好であった5例は1年以上の予後が得られており，孤立性縦隔転移を摘出する意義は十分あると思われた．結語．肝細胞癌の孤立性縦隔転移に対して胸腔鏡下摘出術を行うことで，予後の改善が得られる可能性がある．
Association of Her-2 Expression and Clinicopathological Parameters in Colorectal Carcinoma in Indian Population

BACKGROUND: Human epidermal growth factor receptor 2 (HER-2) is an oncogenic gene and a well-established therapeutic target in several cancers including breast and ovary. AIM: The present study aimed to compare HER-2 expression status with histological grades as well as Clinicopathological parameters including age, bleeding per rectum, pain/burning sensation in defecation and exercise. METHODS: Her-2 status was assessed by immunohistochemistry (IHC). RESULTS: Results of the study shows that 40.96% patients were Her-2 positive for expression and a statistically significant difference (p-value = 0.004) was observed in histological grades where most of the cases were of grade II. We also observed a significant difference in histological grades with gender (p-value = 0.04), as well as in both the age groups ≤ 55 years and > 55 years (p-value = < 0.0001). Patients with the bleeding rectum and pain/burning sensation in defecation had grade II/III tumours (93.4%, 88.7%) respectively. A significant association was observed between bleeding per rectum and pain/burning sensation in defecation. About 95% of patients with pain/burning sensation in defecation had bleeding per rectum. CONCLUSION: To conclude, Her-2 can be a potential prognostic marker in CRC. The role of age, tumour grade and bleeding per rectum/burning sensation in defecation are of significant worth. Thus, CRC cases of high grades can be screened for HER-2/neu positivity so that they can be subjected to mAb-based individualised therapy.
A Simple Way to Synchronize Chaotic Systems with Applications to

In this paper, we give a scheme for synthesizing synchronizing circuits and systems. Synchronization of drive and response system is proved trivially without the need for computing numerically the conditional Lyapunov exponents. We give a definition of the driving and response system having the same functional form, which is more general than the concept of homogeneous driving of Pecora and Carroll [Pecora & Carroll, 1991]. Finally, we show how synchronization coupled with chaos can be used to implement secure communication systems which is inherently error-free in contrast with the signal-masking schemes proposed in [Cuomo & Oppenheim, 1993a,b; Kocarev et al., 1992]
PENGGUNAAN DESAIN GRAFIS PADA MAJALAH HIDAYATULLAHSEBAGAI MEDIA DAKWAH DALAM MENARIK MINAT BACA MAD’U DIBANDAR LAMPUNG

Desain grafis merupakan visualisai/penggambaran dari seni yang digunakan majalah Hidayatullah untuk memberikan tampilan majalah yang memiliki nilai estetika, sebagai kemasan dari media dakwah yaitu majalah Hidayatullah. Permasalahannya adalah dakwah di era modern ini memerlukan kreatifitas dan inovasi agar tetap menarik minat mad’u. salah satunya yaitu desain grafis pada media dakwah mulai banyak diterapkan untuk membuat tampilan yang bagus serta untuk membuat tampilan yang memudahkan mad’u dalam memahami dan membaca. Kemudian yang menjadi pokok permasalahan adalah apakah penggunaan prinsip desain grafis pada majalah Hidayatullah sebagai media dakwah mampu menarik minat baca mad’u di Bandar Lampung. Dakwah Islam harus fleksibel, mampu mengikuti perkembangan zaman, perkembangan umat dan teknologi. Oleh karena itu saat ini desainer grafis mengajak untuk memperbaiki umat dengan mengunakan program desain grafis sebagai media kemasan dakwah untuk memudahkan mad’u (umat) memahami pesan-pesan Islam yang di kontruksi secara interaktif unttuk memperbaiki perilaku umat menjadi baik. Sebagaimana yang telah diterapkan pada tampilan majalah hidayatullah Penelitian ini adalah deskriptif kualitatif dengan menggunakan objek penelitian lapangan. Pengambilan sampel dengan teknik snowball sampling, sehingga akhirnya diperoleh 10 orang sampel dan beberapa informan. Sedangkan alat pengumpul data dalam penelitian ini menggunakan observasi, wawancara, dan dokumentasi. Kemudian setelah data terkumpul barulah dianalisis. Dari penelitian ini penulis mendapat temuan atau kesimpulan sebagai berikut, pertama penggunaan desain grafis pada majalah Hidayatullah berperan dan berpengaruh besar sehingga maksud dan tujuan dari penggunaan desain grafis pada tampilan majalah hidayatullah ini dapat tersampaikan dengan baik. Dengan adanya penggunaan prinsip desain grafis pada majalah Hidayatullah yang terdiri dari komposisi, keseimbangan, irama,perbandingan/proporsi dan kesatuan. Beserta elemen-elemen yang terdapat pada desain grafis yaitu garis, bentuk, tekstur, ruang, dan warna.Penggunaan desain grafis tersebut mampu menarik minat baca mad’u di Bandar Lampung. Hal itu ditandai dengan meningkatnya pelanggan Majalah Hidayatullah dari tahun sebelumnya.
Geographically constrained information retrieval

The state-of-the-art information retrieval systems lack the geographical intelligence needed to effectively answer geography-dependent questions. Two importance research objectives with respect to the above mentioned challenges are addressed in this thesis: how to mine and analyse the geographical information implicit in text, and how to use the geographical knowledge obtained in this way to build models for answering geography-dependent user questions. More specifically, we seek answers to the following (1) how can place names, geographical adjectives and the names of people be used to automatically determine the geographical scopes of documents? (2) how well do the automatically determined scopes of documents compare to human assigned scopes? (3) how best to evaluate of scope resolution systems? (4) how effective is the documents scope in aiding toponyms resolution? (5) how best to evaluate toponym resolution systems? (6) how effective is relevance feedback for Geo-IR? (7) how effective is a scope-controlled toponym selection scheme in relevance feedback procedure? (8) how can scope and type information be incorporated into the document ranking procedure for Geo-IR?
Seroprevalence of hepatitis C and human immunodeficiency viruses in blood donors of northwestern Pakistan.

Background: Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections are major health problems associated with blood transfusion practices in Pakistan. This study was conducted on a large population to asses the epidemiology of HCV and HIV in the North West Frontier Province (N.W.F.P) of Pakistan Methods: Between January 2008 and July 2009, 62,251 healthy blood donors (BDs), aged 17-50, were included. In that group, 61,059 (98.1%) were male and 1192 (1.9%) were female. All donors from the 11 areas of N.W. F.P were screened for HCV and HIV antibodies by ELISA (Biokit). Blood groups were also determined. Results: HCV prevalence was 2.6% while HIV infection was 0.045% in this Pakistani population. Prevalence of HCV and HIV in 2008 was 2.4% and 0.049% respectively. In 2009, it was 3.0% for HCV and 0.038 for HIV. Among the age groups, the prevalence of HCV and HIV was not significantly different (p=0.128). Only 1484 (2.4%) of the donors were voluntary, the remaining were paid and family blood donors. The difference in the number of male and female donors was highly significant (p=0.00001). The B+ blood group was found in 30.5% followed by O+ in 25.9%, A+ in 24.9%, AB+ in 10.4%, A- in 2.6%, B- in 2.5%, O- in 2.3%, and AB- in 0.9%. Our study revealed a higher prevalence of HIV than in most of previous reports. Conclusion: The frequency of HCV infection in blood donors is higher in N.W. F.P than in most of the rest of the world and lower than in other regions of Pakistan. Transfusion of infected blood is a common cause of transmission. HIV prevalence is increasing in Pakistan. Keywords: Blood donors, hematological values, hepatitis C, HIV, northwestern Pakistan
Applying Scalable Interprocedural Pointer Analysis to Embedded Applications

This paper evaluates six different types of interprocedural pointer analyses on 22 telecommunication and media applications and describes their application to an SRAM power reduction technique. Thisconfigurable SRAM provides differentiation of data access time and port counts within a single on-chip structure. Scheduling for configurable SRAM relies on inter-procedural dependence analysis for safe assignment of program data objects to on-chip storage regions with little or no performance degradation. It thus provides a meaningful vehicle for exploring the applicability of and need for various interprocedural analysis techniques, as well as a demonstration of how compilation and hardware techniques can be combined to achieve optimization beyond that for performance.
Increasing Throughput of FPGA-based Streaming Applications : by using Pipelining

The utilization of the used FPGA resources in time is rather low compared to an ASIC due to the lower clock frequency. The efficiency of FPGA resources (lookup tables) can be increased by using designs with many pipeline stages combined with a very high clock frequency. In this work, the automatic insertion of pipeline stages in data paths after synthesis and the usage of high clock frequencies should be investigated. The overall goal is to increase the efficiency and performance of FPGAs. The data paths of critical parts of a design should be analyzed and additional pipeline stages should be automatic inserted.
Everolimus in combination with weekly paclitaxel and trastuzumab in patients (pts) with HER2-overexpressing metastatic breast cancer (MBC) with prior resistance to trastuzumab and taxanes: A multicenter phase II clinical trial.

1013^ Background: Resistance to trastuzumab (H) may be associated with deregulation of PTEN or mutations in PI3K/AKT pathway. Preclinically, everolimus (E), an oral inhibitor of mTOR, enhances activity, reverses resistance to H and demonstrates synergistic activity with paclitaxel (T). The objective of this phase II study was to evaluate the efficacy of E combined with T and H in heavily pretreated HER2-positive MBC pts. Methods: A multicenter, Novartis sponsored, phase II trial was conducted using: T 80mg/m2, IV on days 1, 8 and 15 q4w; H 4mg/kg IV loading dose, then weekly 2mg/kg; E daily 10mg in patients whose disease is resistant to both H (progression on or within 3 months of the end of H therapy for metastatic cancer or within 12 months after the end of neoadjuvant or adjuvant H) and taxanes (progression on or within 4 months of the end of taxane therapy for metastatic cancer or within 12 months after the end of neoadjuvant or adjuvant therapy.) Treatment continued until progression or unacceptable .
Identification des indices acoustiques utilisés lors de la compréhension de la parole dégradée

Bien qu’il existe un large consensus de la communaute scientifique quant au role des indices acoustiques dans la comprehension de la parole, les mecanismes exacts permettant la transformation d’un flux acoustique continu en unites linguistiques elementaires demeurent aujourd’hui largement meconnus. Ceci est en partie du a l’absence d’une methodologie efficace pour l’identification et la caracterisation des primitives auditives de la parole. Depuis les premieres etudes de l’interface acoustico-phonetique par les Haskins Laboratories dans les annees 50, differentes approches ont ete proposees ; cependant, toutes sont fondamentalement limitees par l’artificialite des stimuli utilises, les contraintes du protocole experimental et le poids des connaissances a priori necessaires. Le present travail de these s’est interesse { la mise en oeuvre d’une nouvelle methode tirant parti de la situation de comprehension de parole degradee pour mettre en evidence les indices acoustiques utilises par l’auditeur.Dans un premier temps, nous nous sommes appuyes sur la litterature dans le domaine visuel en adaptant la methode des Images de Classification a une tâche auditive de categorisation de phonemes dans le bruit. En reliant la reponse de l’auditeur { chaque essai a la configuration precise du bruit lors de cet essai, au moyen d’un Modele Lineaire Generalise, il est possible d’estimer le poids des differentes regions temps-frequence dans la decision. Nous avons illustre l’efficacite de notre methode, appelee Image de Classification Auditive, a travers deux exemples : une categorisation /aba/-/ada/, et une categorisation /da/-/ga/ en contexte /al/ ou /aʁ/. Notre analyse a confirme l’implication des attaques des formants F2 et F3, deja suggeree par de precedentes etudes, mais a egalement permis de reveler des indices inattendus. Dans un second temps, nous avons employe cette technique pour comparer les resultats de participants musiciens experts (N=19) ou dyslexiques (N=18) avec ceux de participants controles. Ceci nous a permis d’etudier les specificites des strategies d’ecoute de ces differents groupes.L’ensemble des resultats suggerent que les Images de Classification Auditives pourraient constituer une nouvelle approche, plus precise et plus naturelle, pour explorer et decrire les mecanismes { l’oeuvre au niveau de l’interface acoustico-phonetique.
Database Modelling For the Expertise of Special Needs Teachers

Special needs school is builds for education practice for special needs children. The teacher must have special qualification with special education. Besides special qualification, teacher for special needs children also get full support by Ministry of Education and Culture for doing their research and service, and certification programs for teacher quality improvement. However, in its application, Ministry of Education and Culture have some problem to get the required teacher’s data. To facilitate Ministry of Education and Culture to get the required data, it need an expertise system to accommodate, process, and display the information system of teacher expertise. The design of this expertise system have functional requirements as search system, statistic display process like research statistic, service, and teacher certification, and teacher statistic as a companion. To develop an expertise system, required database design that can meet the needs of the system and accordance to ideal database category. MySQL selected For Database Management System (DBMS). There are some tests for the database design to know if the design already required the needs. The testing done by using query and constraint.
Automated and Portable Hadoop Cluster Orchestration on Clouds with Occopus for Big Data Applications

Apache Hadoop [1], an open-source software framework for storing data in a distributed cluster environment and running applications to process this large amount of data in a fast and efficient way. In the last few years, Hadoop has become a very popular system for analyzing Big Data with its MapReduce [2] framework introduced by Google in 2004. Many scientific applications, such as weather forecasting [3], DNA sequencing [4], and molecular dynamics [5], have been parallelized using Hadoop. However, the deployment of a fully functional Hadoop cluster is not a trivial task, it is currently not in line with the capabilities of the data scientists, and therefore there is still a significant barrier for this technology to spread among data scientists. Combining Hadoop, Cloud and an orchestration tool for dynamically build up Hadoop clusters would help these scientists run their Big Data applications. Complex virtual infrastructures, like Hadoop, with all of its configuration and network design, needs special planning, care and skills by the end-users to have proper functioning Hadoop cluster. One of our main targeted user groups is the Hungarian academic research community and their new computing infrastructure, the MTA Cloud. This paper focuses on utilizing a hybrid, cloud orchestration tool called Occopus [6]. The solution presented in this paper, provides automatic deployment of a fully functional Hadoop cluster without the need for low level understanding of Hadoop architecture or cloud computing. Moreover, (1) it is portable, since the solution does not depend on any cloud-specific feature, (2) it is scalable by utilizing Occopus and Hadoop dynamicity, (3) it does not require any prepared image, (4) it gives the possibility to fine-tune the configuration of the Hadoop components for advanced users and finally (5) it supports short or long-term usage scenarios.
A Review on: Network Load Balancing in Dynamic Data Center

: Achieving efficient resource utilization and guaran-tees of required performance in data centers is difficult. Efficient load balancing, on various parts of data center, is the key to overcome these problems. This paper presents load-balancing in two parts of the data center: network traffic load balancing and virtual server load balancing. We review some of the proposed load balancing systems, and discuss their advantages and challenges.
Accuracy of Consumer Wearable Heart Rate Measurement During an Ecologically Valid 24-Hour Period: Intraindividual Validation Study

Background Wrist-worn smart watches and fitness monitors (ie, wearables) have become widely adopted by consumers and are gaining increased attention from researchers for their potential contribution to naturalistic digital measurement of health in a scalable, mobile, and unobtrusive way. Various studies have examined the accuracy of these devices in controlled laboratory settings (eg, treadmill and stationary bike); however, no studies have investigated the heart rate accuracy of wearables during a continuous and ecologically valid 24-hour period of actual consumer device use conditions. Objective The aim of this study was to determine the heart rate accuracy of 2 popular wearable devices, the Apple Watch 3 and Fitbit Charge 2, as compared with the gold standard reference method, an ambulatory electrocardiogram (ECG), during consumer device use conditions in an individual. Data were collected across 5 daily conditions, including sitting, walking, running, activities of daily living (ADL; eg, chores, brushing teeth), and sleeping. Methods One participant, (first author; 29-year-old Caucasian male) completed a 24-hour ecologically valid protocol by wearing 2 popular wrist wearable devices (Apple Watch 3 and Fitbit Charge 2). In addition, an ambulatory ECG (Vrije Universiteit Ambulatory Monitoring System) was used as the gold standard reference method, which resulted in the collection of 102,740 individual heartbeats. A single-subject design was used to keep all variables constant except for wearable devices while providing a rapid response design to provide initial assessment of wearable accuracy for allowing the research cycle to keep pace with technological advancements. Accuracy of these devices compared with the gold standard ECG was assessed using mean error, mean absolute error, and mean absolute percent error. These data were supplemented with Bland-Altman analyses and concordance class correlation to assess agreement between devices. Results The Apple Watch 3 and Fitbit Charge 2 were generally highly accurate across the 24-hour condition. Specifically, the Apple Watch 3 had a mean difference of −1.80 beats per minute (bpm), a mean absolute error percent of 5.86%, and a mean agreement of 95% when compared with the ECG across 24 hours. The Fitbit Charge 2 had a mean difference of −3.47 bpm, a mean absolute error of 5.96%, and a mean agreement of 91% when compared with the ECG across 24 hours. These findings varied by condition. Conclusions The Apple Watch 3 and the Fitbit Charge 2 provided acceptable heart rate accuracy (<±10%) across the 24 hour and during each activity, except for the Apple Watch 3 during the daily activities condition. Overall, these findings provide preliminary support that these devices appear to be useful for implementing ambulatory measurement of cardiac activity in research studies, especially those where the specific advantages of these methods (eg, scalability, low participant burden) are particularly suited to the population or research question.
CCM (Chronic Care Model) w ramach podstawowej opieki zdrowotnej

sprawnego funkcjonowania systemu opieki nad chorymi przewlekle jest podstawowa opieka zdrowotna realizowana przez wielodyscyplinarny zespol profesjonalistow, kierowana przede wszystkim do pacjentow chorych przewlekle i ich potrzeby biopsychospoleczne. coraz szersze zainteresowanie wiąze sie takze z probą ksztaltowania opieki zdrowotnej w strone spelniania oczekiwan chorych przewlekle z rownoczesną ewolucją systemu reaktywnego (reagującego, gdy zglasza sie osoba juz chora) w proaktywny (dązący do utrzymania wysokiego poziomu jakości zycia). powyzsze elementy ma realizowac Model opieki nad chorymi przewlekle (Chronic Care Model – ccM) w ramach podstawowej opieki zdrowotnej zakladający: partnerstwo miedzy wspoldecydującymi pacjentami i profesjonalistami opieki zdrowotnej, wspolprace w ramach opieki oraz edukacje uzupelnioną wsparciem dla pacjentow w osiąganiu najwyzszej mozliwej jakości zycia. Slowa kluczowe: chorzy przewlekle, podstawowa opieka zdrowotna, choroby niezakaźne It is suggested that health systems should be modeled on the structure supporting the “management of chronic diseases” – depending of course on local capabilities, the needs and expectations of patients. For many years, there has been a need to define the system of care within the home environment of patients, focused on the individual health needs of patients. It has been shown that home care has a clinical efficacy with lower risk of hospitalization and increased satisfaction ratings. It is assumed that the most effective level for the development and smooth functioning of the system of care for the chronically ill is the primary health care administered by a multidisciplinary team of professionals, led primarily for chronically ill patients and their bio-psycho-social needs. More and more interest has also been associated with an attempt to shape health care in meeting the expectations of chronically ill patients and simultaneous evolution of reactive system (responsive when a person is already sick) to proactive (seeking to maintain a level of quality of life). these elements should be realized by chronic care Model (ccM) in the primary care setting assuming: a partnership between cooperating patients and health care professionals, cooperation within care and education complemented by support for patients in achieving the highest possible quality of life.
Architecture and History

‘Architecture and History’: I take my title from a lecture by William Morris, delivered in 1884. One of its themes was the link between art and society, between style and culture, between architecture past, present, and future. My lecture takes up a similar theme from a rather different perspective. I want to concentrate on the stylistic problems created by those assumptions of continuity and reciprocity. In a nutshell, Morris’s generation was faced with an architecture apparently dying from a surfeit of history. In an age of extraordinary scientific and technological progress — an age bewitched by theories of evolution — architecture seemed to be mesmerized by the Renaissance, by the Middle Ages, by Antiquity. Hence the dilemma of style. What I shall try to do is to examine that Victorian problem of style through the eyes of the Victorians themselves. But this is an inaugural lecture. So the witnesses I shall call will be my predecessors.