Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis and extension of an open-source VHDL model of a general-purpose GPU

In the last years, high-performance computing requirements leaded to unite the advantages brought by parallel computing typical of graphic processors with the flexibility of the general-purpose programming. This is how the so-called GPGPUs (General-Purpose Graphic Processing Units) have started to be developed and diffused on the market. However, due to their rigid microarchitectural features, GPGPUs are not available as support unit for most of the computing systems. On the contrary, FPGAs (Field Programmable Gate Array) are can be seen as soft (reconfigurable) hardware accelerators to be placed next to CPUs, because they are perfectly adaptable to the designer requirements. Although, when using FPGAs a certain degree of expertise in HDL (Hardware Description Language) coding is expected, and besides, reconfiguration of the logic may take unaffordable times. In order to put together the pros of the two platforms alleviating their drawbacks, University of Massachusetts has studied a model for a soft integer GPGPU optimized for FPGA implementation which is called FlexGrip (FLEXible GRaphIc Processor). Beyond the benefits of using it as an accelerator for FPGA, FlexGrip also has the trivial but not obvious merit of offering the academic community an open-source model of a graphic processor, due to the reservation adopted by GPU manufacturer about the implementation details of their devices. The accelerated development that some sectors of the industry have known in the last years from the automation point of view (think for example of the automotive industry) necessarily pushes companies to request that these components have a sufficiently high degree of reliability. The challenge is gathered by the departments and the academic teams involved in IT reliability, such as ours, which are trying to offer innovative techniques for building efficient SBST (Software-Based Self Test) for such devices. In fact, many of the techniques used routinely for the self-test of normal processors cannot be reused here, due to the presence of specific modules that are to be precisely studied at the gate level to identify all the possible faults. This is clearly not possible without the netlist of a working GPU. Then, this thesis work has been focused on the correction of the VHDL model of FlexGrip through an instruction-level analysis. The behavior of all the nominally supported functionalities has been analyzed by compiling a high number of random CUDA kernels to make appear as many formats as possible of each of the instructions, due to the absence of any reference manual for the effective ISA by Nvidia. Formats which were not fully working or implemented have been corrected and completed, as well as collected in a tool which is able to write down the corresponding mnemonic and binary in the . SASS input file (the format of the assembly language for the Nvidia family).
Development of DuplexPolymerase Chain Reactionin-house assay to Detect of Chlamydia trachomatis and Neisseria gonorrhoeaefrom Genital Discharge in Patient with Sexual Transmitted Infections

The incidence of sexually transmitted infections (STIs) with discharge in Indonesia to high-risk groups provide dominant pattern of Chlamydia trachomatis(CT) and Neisseriagonorrheae(NG) infection. Pathogenesis change of CT and NGinfection suggeststhat routine syndromic approach diagnostic is no longer accurate. To develop detection system of CTand NG using duplex polymerase chain reaction (PCR) assay to genital discharge in patient with STIs. Three phases: firstly was PCR assay optimalization to annealing time and temperature, primer concentration, centrifugation time and elution volume, secondly, specificity test and thirdly duplex PCR assay application to clinical specimen. Duplex PCR assay optimalization gave results as follow: annealing temperature and time 54°C and 60 seconds, CTand NG primer concentration were 0,7μM and0,5μM, centrifugation time 10 minutes, and elution volume 60 μl. Detection limit of duplex PCR to CTand NG 0.927 and 1.19 pg / PCR reaction, respectively. Duplex PCR to detect NG has ensitivity, specificity, positive predictive value and negative predictive value were 100%, 61.9%, 20%, and 100% in endocervical specimens, respectively and 75%, 40%, 50%, and 66.67%, in male urethral specimens respectively. Duplex PCR to detect CT was compared with chlamydial antigen detection test were show positive results higher both in endocervical and male urethral specimens (10:3 and 1:0). Development of detection system of CT and NG using duplex PCR assay is applicable to endocervical and male urethral swab specimens.
Immunocytochemical Localization of a 58kDa Glycoprotein of Epididymal Fluid of Rhesus Monkey (Macaca mulatta)

Abstract Jamal, F. and Srivastav, A. 2010. Immunocytochemical localization of a 58kDa glycoprotein of epididymal fluid of rhesus monkey (Macaca mulatta). J. Appl. Anim. Res., 37: 177–183. A 58kDa glycoprotein of epididymal fluid of rhesus monkey, using lectins Lens culinaris agglutinin (LCA) and Ricinus communis agglutinin (RCA), was studied raising polyclonal antisera against this protein to study cross-reactivity with the epididymal fluids of mice, rat, hamster, guinea pig, rabbit and Triton X-100 human sperm extract. The present study aimed at delineating the distribution of this 58kDa antigen in testis, epididymis, vas deferens, seminal vesicle and prostate tissues of rhesus monkey using immunological probes, depicting their ontogeny and its association with maturing spermatozoa. The epitopes cross-reacting with 58kDa antisera were predominantly distributed in the stroma region and luminal spermatozoa throughout the epididymis, vas deferens and prostate tissues. The epitopes against this 58kDa antisera have been conserved and could be explored for immuno-contraception in humans.
Assessment of negative symptoms in male and female schizophrenia patients using the Polish version of the Brief Negative Syndrome Scale and Self-evaluation of Negative Symptoms

Introduction: The assessment of the severity of negative symptoms is an important diagnostic element in schizophrenia. Recently, two new diagnostic tools have been introduced, included in second-generation scales: the Brief Negative Symptom Scale (BNSS) and Self-evaluation of Negative Symptoms (SNS). The aim of the study is to evaluate the differences between men and women in the severity of negative symptoms using the Polish versions of BNSS and SNS. Material and methods: The study involved 40 patients (20 men, 20 women) with paranoid schizophrenia (ICD-10). They were in the period of symptomatic stabilisation (PANSS < 80 points) and had received unchanged pharmacological treatment during the preceding three months. The assessment of the severity of the disease symptoms was made using the PANSS. The Polish versions of the BNSS and SNS were used to assess negative symptoms. Results: There were no gender differences regarding the age and duration of the illness. The mean total PANSS score was higher in men. Negative symptoms evaluated by the BNSS showed significantly greater scores in men compared to women in asociality (internal experience and total), avolition (internal experience and total), and alogia (spontaneous elaboration). There were no gender differences using the SNS. Conclusions: The results indicate the existence of significant gender differences in the assessment of negative symptoms in three subscales of negative
A Highly Nonlinear Boussinesq Wave Model of Improved Dispersion Characteristics

In the present study a modified Boussinesq-type model is derived to account for propagation of regular and irregular waves in two horizontal dimensions. An improvement of the linear and nonlinear characteristics of the model is obtained by optimizing the coefficients of each term in the momentum equation, expanding in this way its applicability in very deep waters and thus overcoming a dominant short-coming of most likewise models. The values of the coefficients were obtained by an inverse method in such a way to satisfy exactly the dispersion relation in terms of both first and second order analyse. The modified model was applied to simulate the propagation of regular and irregular waves in one horizontal dimension, in a variety of bottom profiles, such as constant depth, mild slope, submerged obstacles. The simulations are compared with experimental data and analytical results, indicating very good agreement in most cases.
Assessment of prothrombin and activated partial thromboplastin time in dogs.

Blood coagulation is an important part of haemostasis. Laboratory evaluation of this haemostatic process involves assessment of coagulation profile. The aim of this study was to estimate the reference range for prothrombin time (PT) and activated partial thromboplastin time (aPTT) in normal dogs. These determinations were made on 15 healthy male and female dogs from various breeds using a semiautomatic coagulometer using commercially available kits for human medicine. The range value for aPTT was 43.17±2.39 second and PT range value was 12.12±0.57 second.
ASYMPTOTIC COST OF CUTTING DOWN RANDOM FREE TREES

The limit distribution of the total cost incurred by splitting a tree uniformly distributed on the set of all finite free trees, appears as an additive functional induced by a toll equal to the square of the size of tree. The main tools used are the recent results connecting the asymptotics of generating functions with the asymptotics of their Hadamard product, and the method of moments.
Espacialización de datos poblacionales de la provincia de Cádiz a escala de detalle

Spatialization of socio-economic data constitutes a key factor in a wide range of applications dealing with planning, management and research. Although many statistical data is gathered at individual or home level, information is afterwards georeferred by area-based aggregation (census track, municipalities.). This paper shows some results derived from a geocoding process of population data for Cadiz province in 2011. This geocoding process uses the official digital street map of Andalucia as the spatial data reference, and the enterprice-GIS geocoding tools as software environment. Succesfully geocoded data at address level rises to 60%, although higher percentages are reach if lower confidence intervals are assumed. Obtained data allows different kind of geostatistical analysis and cartographic representations for demographic information diffusion.
Effect of inulin-type fructans on body weight gain and selected biochemical parameters at calcium hypoalimentation in rats.

The aim of the present study was to determine changes in body weight gain and the level of selected biochemical blood serum parameters under conditions of diminished calcium content in rat diet and after introducing inulin-type fructans into the diet. The effect of inulin or oligofructose on the content of calcium in femur was studied as well. The 21-day experiments were carried out on albinotic male Wistar rats. The animals were fed with semi-synthetic AIN’93 G diet with various amounts of calcium in a mineral mix (Ca 100 , Ca 50 , Ca 25 ) and containing inulin (Ca 50 +I, Ca 25 +I) or oligofructose (Ca 50 +OF, Ca 25 +OF) in conditions of Ca deficiency – 50% and 75%, respectively. Our results showed that the level of total and ionised calcium, magnesium and phosphorus in blood serum as well as Ca content in femur varied with the amount of Ca in rat diet. The intake of inulin-type fructans increased significantly Ca content in rat femur, both at 50% (33% w/w Ca in the Ca 50 group vs. 38% w/w for animals fed diet with inulin, and 37% w/w for oligofructose fed rats) and 25% of the recommended dietary calcium level (25% w/w Ca25 group, 31% – after inulin intake, and 30% after oligofructose consumption).
Evaluation of a shelf-stable direct-fed microbial for control of Escherichia coli O157 in commercial feedlot cattle

Stanford, K, Gibb, D. and McAllister, T. A. 2013. Evaluation of a shelf-stable direct-fed microbial for control of Escherichia coli O157 in commercial feedlot cattle. Can. J. Anim. Sci. 93: 535-542. A direct-fed microbial (DFM) registered for use in cattle in Canada containing Lactobacillus acidophilus strain BT-1386 and a Saccharomyces cerevisiae yeast autolysate was evaluated for control of E. coli O157. Weaned calves entered the feedlot in October and November and in January were sorted into Control (12 pens with a total of 2170 calves) and DFM treatment groups (10 pens with a total of 2040 calves). Although targeted dosage of L. acidophilus was 9 log10 colony forming units (CFU) head-1 d-1, analyses after storage at ambient temperature showed an average dose of 8.6 Log10 CFU head-1 d-1 and demonstrated stability of DFM over the range of temperatures encountered (-32.6 to 32.9°C) during storage. Calves entering the feedlot had low prevalence (0.8%) of E. coli O157 in feces, which increased to 11.2% in January. A 47°C range in ambient temperature for that month may have stressed cattle and led to increased shedding of E. coli O157 compared with seasonal norms. Comparing hide swabs collected at initiation of DFM feeding with those at shipping for slaughter, prevalence of E. coli O157 declined (P<0.05) in cattle fed DFM, although prevalence of E. coli O157 in hide swabs from Control and DFM-treated cattle did not differ at any time. As well, numbers of E. coli O157 and prevalence of the organism in fecal pats did not differ among treatments. Colonization of calves with E. coli O157 prior to DFM feeding likely reduced efficacy of DFM in the present study. Additional information regarding timing of feeding DFM relative to interactions among organisms within the gastrointestinal tract of cattle are required to ensure consistent efficacy of DFM for pre-harvest control of E. coli O157.
Giant kelp (Macrocystis pyrifera) survival in deep water (25–40 m) during El Niño of 1997–1998 in Baja California, Mexico

Abstract During the 1997–1998 El Niño, we examined seasonally a giant kelp population in deep water (25–40 m) off the coast of Northern Baja California. Though most populations in the region completely disappeared, large fertile adults survived the entire warming event at depth. At 25 m, there was no significant change in density or number of fronds per individual during the warming period from spring 1997 to spring 1998, though the surface canopy sloughed off (died) down to 15 m depth. By summer 1998, recruitment occurred at all depths at the site. Adult survival at depth was most likely important in post-disturbance recovery in surrounding populations by occupying substratum, providing vegetative growth, and producing spores. Survival in deep water during this extreme El Niño may have been due to local hydrography, such as internal waves bringing cool nitrate-rich water into the deeper regions of the shelf from below the thermocline, providing a refugium against the warm temperatures, low nutrients, and heavy wave action associated with warming events. Deep-water populations may regularly survive El Niño warming in this region due to internal wave activity, and go undetected due to the depth at which they occur and the sloughing of the shallow (<15 m) biomass.
Genetic Monitoring of a Critically-Endangered Seal Population Based on Field-Collected Placentas

Genetic analyses of non-invasively collected samples are increasingly being used in the monitoring of wildlife populations and individuals. This study is the first describing the use of placentas as non-invasive genetic samples from a natural population. We collected 66 placentas from birth-lair sites of Saimaa ringed seals (Phoca hispida saimensis) after the breeding seasons, with the aim of obtaining DNA from both the pup and the mother. Umbilical cord samples proved to yield the pup genotypes, but mothers could not be genotyped with confidence. Comparisons with existing mtDNA and microsatellite reference data sets showed that placentas can be used for inferring population-level genetic parameters. Our microsatellite panel provided sufficient resolution for genetic identification of individuals but, due to the extremely low variability of the population, parentage and sibship could not be inferred reliably. Field-collected placentas could provide means for genetic monitoring of many other seal species as well.
Pyromancy: Reading Stories in the Flames

Abstract: A consensus history of fire in the United States has emerged over the past decade. It correctly identifies fire suppression's liabilities, while probably over‐enthusing about fire‐science capabilities. What it lacks, however, is a context of the subject's larger, braided narratives. There is, first, the grand story of fire on Earth. Quite apart from active suppression, open fire is disappearing in competition with industrial combustion. Second, there is the peculiar narrative of the public lands, the prime domain for wildland fires. These lands, and the institutions for their management, are rapidly changing. They began as “imperial” institutions, but now are devolving, privatizing, and otherwise decolonizing. Fire will change with those reforms. Third, there is a national narrative, currently obsessed with the collision of the wild and the exurban. This will probably pass within 5–6 years. Finally, there is the evolving narrative of how we imagine fire. We need a truly biological theory of fire, one in which we can flourish as unique fire creatures.
Interferon-α / β-Receptor Interactions: A Complex Story Unfolding

The Type I interferons (IFN-α / s) exhibit pleiotropic biological activities. Notably, the different IFN subtypes activate the same cell surface receptor complex to mediate variable responses. Accumulating evidence suggests that distinct differences in critical amino acid residues among the different IFN-αs and IFN-s determine the nature of the ligand-receptor interaction and the subsequent responses. This review focuses on IFN-receptor interactions, the key residues involved in this interaction and the potential for targeted modifications of the ligand to enhance bioactivity.
A new index to evaluate anomalies of trace elements in soils: the case of SE Spain

In this work, an index is established to detect anomalies in trace elements in the soil. This index, which relates the total concentration of each element with the regional geochemical background value of the element considered, was defined by studying the levels of trace elements from different soils located in SE Spain. In the area, a previous screening of trace elements detected seven zones with anomalies and revealed two conflictive areas: Sierra Gador and Cabo de Gata. In each zone, a second sampling was undertaken at two different depths (0-20 cm and 20-40 cm). The results indicate that the main anomalies were due to arsenic (As), lead (Pb), and zinc (Zn). In Sierra Gador Pb was the element that registered the highest rate of enrichment with respect to the regional geochemical background, reaching values up to 270-fold higher in some samples. In this zone, more than 50% of the samples were anomalous in any of the trace elements studied (higher than regional geochemical background). In Cabo de Gata, As concentration was higher than the geochemical background in more than 40% of the samples; meanwhile Pb concentration was higher in 50% of the samples. Additional key words: enrichment index, geochemical background, soil pollution. Resumen Nuevo indice para evaluar anomalias de elementos traza en suelos: el caso del SE espanol En este trabajo establecemos un indice para detectar anomalias en el contenido de elementos traza en suelos. Este indice relaciona el contenido total de cada elemento traza con el fondo geoquimico regional, definido mediante el estudio de los niveles de elementos traza en diferentes suelos localizados en el sureste espanol. En un primer estudio sobre niveles de electos traza en suelos del area de estudio detectaron siete zonas con anomalias, de las cuales dos fueron consideradas conflictivas: Sierra de Gador y Cabo de Gata. En cada una de estas dos zonas se realizo un segundo estudio mas exhaustivo a dos niveles de profundidad (0-20 y 20-40 cm). Los resultados indican que las principales anomalias correspondes a los niveles de As, Pb y Zn. En Sierra de Gador el Pb es el elemento que presenta una mayor tasa de enriquecimiento con respecto al fondo geoquimico regional, con valores puntuales que lo superan hasta 270 veces. Tambien en esta zona mas del 50% de las muestras presentan anomalias en alguno de los elementos analizados. En Cabo de Gata el As supera el fondo geoquimico regional en mas del 40% de las muestras; mientras que el Pb lo supera en el 50% de las muestras. Palabras clave adicionales: contaminacion de suelos, fondo geoquimico, indice de enriquecimiento.
Regulations of P-Glycoprotein/ABCB1/MDR1 in Human Cancer Cells

Multidrug resistance (MDR) in cancer cells is a phenotype whereby cells display reduced sensitivity to anticancer drugs, based on a variety of mechanisms, including an increase in drug efflux, the reduction of drug uptake, the activation of cell growth and survival signaling, the promotion of DNA repair, and the inhibition of apoptosis signaling. Increased expression of the plasma membrane drug efflux pumps, the ATP-binding cassette (ABC) transporters, is involved in MDR. P-Glycoprotein/ABCB1 is a member of the ABC transporter family, and facilitates the efflux of various anticancer drugs, including anthracyclines, vinca alkaloids, epipodophyllotoxins, taxanes, and kinase inhibitors, from cells. P-Glycoprotein is also expressed in normal tissues and cells, including the kidney, liver, colon, and adrenal gland, to transport and/or secrete substrates and at the blood-brain, blood-placenta, and blood-testis barriers to protect these tissues from toxic substances. To understand the mechanistic functions of P-glycoprotein and to overcome MDR, investigators have identified the substrates and competitive inhibitors of P-glycoprotein. Recently, we and other groups reported associations between cellular signaling pathways and the expression, stability, degradation, localization, and activity of P-glycoprotein. The present review summarizes the currently available information about the transcriptional and posttranslational regulation of P-glycoprotein expression and function.
Analytical Model for Just-in-Time Purchasing

Just-in-Time purchasing strategy is adopted by organizations to gain advantage over their competitors. Implementation of purchasing strategy can increase firms’ performance. Just-in-Time purchasing strategy has benefits like higher inventory turnover, increased product quality and productivity. This strategy lead to a reduction in product costs. Lower prices will lead to increased market share and profit. This paper is based on model of Just-in-Time purchasing factors like top management commitment, employee relations, training, supplier quality management, transportation, and quantities.
Leveraging Digital Twin Technology in Model-Based Systems Engineering

Digital twin, a concept introduced in 2002, is becoming increasingly relevant to systems engineering and, more specifically, to model-based system engineering (MBSE). A digital twin, like a virtual prototype, is a dynamic digital representation of a physical system. However, unlike a virtual prototype, a digital twin is a virtual instance of a physical system (twin) that is continually updated with the latter’s performance, maintenance, and health status data throughout the physical system’s life cycle. This paper presents an overall vision and rationale for incorporating digital twin technology into MBSE. The paper discusses the benefits of integrating digital twins with system simulation and Internet of Things (IoT) in support of MBSE and provides specific examples of the use and benefits of digital twin technology in different industries. It concludes with a recommendation to make digital twin technology an integral part of MBSE methodology and experimentation testbeds.