Miracle-dz/UniFAR-FTUs huggingface dataset:
Antenna Decoupling by Common and Differential Modes Cancellation

In this article, a general decoupling method based on a new perspective of common mode (CM) and differential mode (DM) cancellation is proposed. For two closely spaced antennas, the mutual coupling effect can be analyzed and solved by exciting them simultaneously with in-phase (CM) and out-of-phase (DM) signals. It is theoretically proved that, if CM and DM impedances are the same, the mutual coupling effect between two separated antennas can be totally eliminated. Therefore, we can solve the coupling problem by CM and DM impedance analysis and exploit the unique field properties of characteristic modes to assist in antenna decoupling in a physical intuitive way. To validate the feasibility of this method, two practical design examples, including the decoupling between closely spaced dipole antennas and planar inverted-F antennas, are proposed. Both design examples have demonstrated that the proposed method can provide a systemic design guideline for antenna decoupling and achieve better decoupling performance compared to the conventional decoupling techniques. We forecast the proposed decoupling scheme, with a simplified decoupling procedure, has great potential for the applications of antenna arrays and multi-input multi-output (MIMO) systems.
Utilization of Infrared Thermography in Cattle Production and Its Application Potency in Indonesia

Infrared thermography (IRT) is a non-invasive remote sensing method to detect temperature. Many studies have shown that temperature in several regions of the body could be representative of core body temperature. Body temperature of cattle can be used to evaluate health status, stress, thermal balance, and feed efficiency. The aim of this article is to review utilization of IRT in cattle production system and its potency to be applied in Indonesia. The ability of IRT to detect even the small change of body surface temperature has made this device is very useful in cattle production industry. Infrared thermography has been used as a tool to detect an early detection of inflammation as sign of some diseases such as mastitis, foot and mouth disease. Infrared thermography can also evaluate feed efficiency through detection of heat production produced by metabolism process. Some important constraints of cattle production in Indonesia such as diseases and low feed efficiency may have strong correlation with body temperature change. Therefore, IRT is very potential to be applied in cattle farms in Indonesia.
Robust Network Enhancement From Flawed Networks

Network data in real-world tends to be error-prone due to incomplete sampling, imperfect measurements, etc.; this in turn results in inaccurate results when performing network analysis or modeling, such as node classification and link prediction, on these flawed networks. In this paper, we aim to reconstruct a reliable network from a flawed, undirected, unweighted network, a process referred to network enhancement. More specifically, network enhancement aims to detect the noisy links that are observed in the network but should not exist in the real world, as well as to predict the missing links that do indeed exist in the real world yet remain unobserved. While some attempts have been made to detect either noisy links or missing links, few of these works have considered unifying these two tasks, even though they are inter-dependent and capable of mutually boosting each others’ performance. In this paper, we therefore propose E-Net, an end-to-end graph neural network model, to leverage the mutual influence of these two tasks in order to achieve both goals more effectively. On one hand, detecting noisy links can benefit the performance of missing link prediction, while on the other hand, predicting missing links can provide indirect supervision for detecting noisy link detection when the labels of these noisy links are unavailable. Moreover, by proposing a subgraph extraction mechanism based on random walk with restart, the model can be scaled up to large networks and is able to preserve the local and global structural characteristics. The experimental results on several types of large networks demonstrate that the proposed model obtains an improvement of 10.7 percent on average in terms of F1 for predicting missing links, along with an average of 3.7 percent improvement in terms of precision for detecting noisy links compared with the state-of-the-art baselines.
New cassava cultivars for starch and flour production in the Cerrado of Central Brazil

The cassava cultivars BRS 417, BRS 418 and BRS 419 are the first specifically developed for flour and starch production in the Cerrado biome of Central Brazil. They are promising for higher yields, lower production costs (mechanical planting) and the increase of genetic variability in cassava crops.
Aplicação de Técnicas de Aprendizado de Máquina para Previsão do IBOVESPA

Matheus Scalco Hernandes Engenharia de Produção, Escola Politécnica EP, Pontifícia Universidade Católica do Paraná PUCPR Curitiba, Brasil matheus.hernandes@pucpr.br Leandro dos Santos Coelho Programa de Pós-Graduação em Engenharia de Produção e Sistemas PPGEPS, Escola Politécnica EP, Pontifícia Universidade Católica do Paraná PUCPR Departamento de Engenharia Elétrica DEE, Universidade Federal do Paraná UFPR Curitiba, Brasil leandro.coelho@pucpr.br Roberto Zanetti Freire Programa de Pós-Graduação em Engenharia de Produção e Sistemas PPGEPS, Escola Politécnica EP, Pontifícia Universidade Católica do Paraná PUCPR Curitiba, Brasil roberto.freire@pucpr.br
Combinatorial library generation, molecular docking and molecular dynamics simulations for enhancing the isoflavone scaffold in phosphodiesterase inhibition

Isoflavones are listed among the most widely studied natural compounds in light of their several biological properties, one of which consists in their ability to inhibit phosphodiesterases (PDEs). The enzymes from this class are deputed to the regulation of the 3′,5′-cyclic adenosine monophosphate (cAMP) and 3′,5′-cyclic guanosine monophosphate (cGMP) levels in the central and in the peripheral nervous systems (CNS and PNS), thus affecting several downstream pathways involved in different diseases. In this work, an extensive set of semi-synthetically obtainable molecules was generated by a combinatorial approach starting from the isoflavone scaffold with the aim of optimizing the interaction with the macromolecule and identifying new putative hit compounds. More specifically, a docking protocol was developed, validated and then adopted to screen the generated compounds towards PDE4, PDE5 and PDE9, three isoforms which are known to be involved in neurodegenerative disorders. Then, a structure based analysis was employed to guide the identification of the most promising hits based on the interactions with specific residues in the metal binding pocket of the PDEs, which have been proved to be crucial for triggering enzymatic inhibition. Lastly, molecular dynamics (MD) simulations were conducted to study with greater accuracy the binding of these compounds with the considered macromolecules. This study led to the set up and validation of a multi-technique computational approach for efficiently screening molecular structures towards PDE isoforms involved in neurodegeneration, and may pave the way for more targeted development of new, semi-synthetic potential PDE inhibitors derived from the isoflavone scaffold.
Is unemployment caused by a socioeconomic phenomenon in the case of Kuwait

This study examines the main macroeconomic factors triggering unemployment in Kuwait. In particular, it examines the impact of GDP growth, inflation rate, government expenditure on education, oil prices, and population growth on unemployment. The yearly data sample covers the period between 1993 and 2016. The estimated model is tested using time series analyses, such as a unit root test (the Augmented Dickey-Fuller test), the autoregressive distributed lag (ARDL) model (bounds testing), the error correction model (VECM), and the Granger causality test. The findings indicate that oil prices, population growth, GDP growth, and government spending on education Granger cause unemployment in both the short run and long run. Moreover, oil prices and government expenditure on education exhibited a significant negative effect on unemployment in the long run. Given the unique characteristics of the demographic features of Kuwait's population, this paper finds that the population growth rate contributes to unemployment in Kuwait, indicating that the increased population of expatriates causes unemployment among Kuwaiti nationals.
Effect of adding astaxanthin and taurine to the Tris extender on the semen quality of Awassi rams during cooling storage

H.J. Neamah and A.A. Houbi Department of Animal Production, Agricultural Engineering Sciences, College, University of Baghdad, Iraq Corresponding author: har_H15@yahoo.com Abstract This study was carried out at the animal farm\ Department of Animal Production\ Agricultural Engineering Sciences, College \ University of Baghdad, Iraq, during the period from 3\2 -28 \9\ 2019, to explore the effect of the adding astaxanthin and taurine to Tris extender on post-cooling semen characteristics of Awassi rams for different periods. In this experiment, used three mature Awassi rams. The semen was divided into nine experiments. Control group (without addition), T1 (1μМ astaxanthin), T2 (0.5 μМ astaxanthin), T3 (35 mM taurine), T4 (45 mM taurine), T5 (1μМ (astaxanthin and 35 mM taurine), T6 (1μМ astaxanthin and 45 mM taurine), T7 (0.5 μМ astaxanthin and 35 mM taurine) and T8 (0.5 μМ astaxanthin and 45 mM taurine), individual sperm motility, acrosome integrity, sperm abnormality and live sperm percentage were investigated following different periods. Using a combination of astaxanthin and taurine improved the individual sperm motility after dilution and after 72 hours. The addition of 45 μМ taurine has improved the percentage of acrosome integrity during different cooling periods. While the sperm abnormality was decreased after dilution and after 42 hours in group T6 and after 24, 48 in group T1. The results were showing that added astaxanthin and taurine separately or as a combination improve the live sperm percentage after dilution and after 24 hours. Through this study, we conclude the importance of adding astaxanthin and taurine in improving the qualities of diluted semen of Awassi rams.
Identification of on-target mutagenesis during correction of a beta-thalassemia splice mutation in iPS cells with optimised CRISPR/Cas9-double nickase reveals potential safety concerns

Precise and accurate gene correction is crucial for enabling iPSC-based therapies, and Cas9-Nickase based approaches are increasingly considered for in vivo correction of diseases such as beta-thalassemia. Here, we generate footprint-free induced pluripotent stem cells from a patient with a beta-thalassemia mutation (IVSII-1 G > A) and employ a double Cas9nickase-mediated correction strategy combined with a piggyBac transposon-modified donor vector for gene correction. Our approach further aimed to minimize the formation of adjacent single-strand breaks at the targeted allele through the destruction of the binding site for one guide and the use of a synonymous protospacer adjacent motif blocking mutation (canonical PAM sequence 5'-NGG-3' is changed to 5'-NCG-3', where N indicates any nucleobase) for the other guide. We show that this strategy indeed not only permits bi-allelic seamless repair of the beta-globin gene splice site mutation and negligible off-target mutagenesis or re-editing of the targeted allele but also results in unexpected on-target mutagenesis with some guide RNAs (gRNAs) in several targeted clones. This study thus not only validates a framework for seamless gene correction with enhanced specificity and accuracy but also highlights potential safety concerns associated with Cas9-nickase based gene correction.
Nucleic acid cleavage with a hyperthermophilic Cas9 from an uncultured Ignavibacterium

Significance Cas9 proteins have revolutionized biotechnology by enabling flexible and facile targeted cleavage of nucleic acids. Nearly all of these proteins are active only at moderate, near-physiological temperatures. Through mini-metagenomic sequencing of hot spring samples from Yellowstone National Park, we discovered and characterized a novel hyperthermophilic Cas9 protein from an unculturable Ignavibacterium. This Cas9 protein, IgnaviCas9, expands the temperature range at which targeted nucleic acid cleavage is possible, thus speeding the development of new biotechnological techniques. We demonstrated one such application by using IgnaviCas9 to deplete undesired amplicons during the amplification step of library preparation in sequencing workflows. This Cas9 protein underscores the exciting applications that can be made possible by exploring nature’s diversity. Clustered regularly interspaced short palindromic repeats (CRISPR)-associated 9 (Cas9) systems have been effectively harnessed to engineer the genomes of organisms from across the tree of life. Nearly all currently characterized Cas9 proteins are derived from mesophilic bacteria, and canonical Cas9 systems are challenged by applications requiring enhanced stability or elevated temperatures. We discovered IgnaviCas9, a Cas9 protein from a hyperthermophilic Ignavibacterium identified through mini-metagenomic sequencing of samples from a hot spring. IgnaviCas9 is active at temperatures up to 100 °C in vitro, which enables DNA cleavage beyond the 44 °C limit of Streptococcus pyogenes Cas9 (SpyCas9) and the 70 °C limit of both Geobacillus stearothermophilus Cas9 (GeoCas9) and Geobacillus thermodenitrificans T12 Cas9 (ThermoCas9). As a potential application of this enzyme, we demonstrate that IgnaviCas9 can be used in bacterial RNA-seq library preparation to remove unwanted cDNA from 16s ribosomal rRNA without increasing the number of steps, thus underscoring the benefits provided by its exceptional thermostability in improving molecular biology and genomic workflows. IgnaviCas9 is an exciting addition to the CRISPR-Cas9 toolbox and expands its temperature range.
Comparison of the effectiveness of allopurinol and methylprednisolone in reducing reperfusion injury in coronary artery bypass surgery

Background: Reperfusion injury due to the release of ROS when using CPB and the return of oxygen-rich blood flow to ischemic myocardium after the release of aortic clamps, can cause myocardial dysfunction. Allopurinol as an inhibitor of xanthine oxidase and methylprednisolone is used to reduce the effects of inflammation and reperfusion injury. Method: A double-blind randomized clinical trial study was conducted on 42 patients undergoing coronary artery bypass surgery using CPB between October 2019 and March 2020, which was allocated to the allopurinol group or the methylprednisolone group. Examination of biomarkers of reperfusion injury is carried out by examination of a blood sample of MDA which is performed shortly after the installation of a central venous catheter and 5 minutes after the aortic clamp are removed. MDA examination is done by the ELISA method. Assessment of VIS was carried out in the first 24 hours of postsurgical treatment. While the assessment of the incidence of postoperative arial fibrilation was performed during the first 48 hours after surgery. Results: MDA post reperfusion levels increased significantly in the administration of methylprednisolone (p=0.041) and increased not significantly in the administration of allopurinol (p=0.251). The postoperative VIS value in the administration of allopurinol was significantly lower than in the administration of methylprednisolone (median 6 vs. 22, p = 0.009). The incidence of POAF in the two groups showed no differences were statistically significant (p = 0.231). Conclusion: Allopurinol is more effective than methylprednisolone and can be used in efforts to reduce reperfusion injury in coronary artery bypass surgery.
Jatropha curcas leaves extract as corrosion inhibitor for mild steel in 1M hydrochloric acid

Corrosion is one of the greatest menace combating metallic materials. This research sought to find a way of minimizing it using a plant based inhibitor that is readily available and eco-friendly. The inhibitive effect of the acid extract of jatropha curcas leaves on the corrosion inhibition of mild steel using mass loss method was investigated. The study was carried out at different concentration of the extract and temperature. Inhibition efficiency of 93.69% was obtained and this show that jatropha curcas leaves extract could inhibit mild steel corrosion in acidic medium. The inhibition efficiency of the extract was found to increase as both the concentration of the extract and temperature increased. Langmuir isotherm was best fitted into the results. The activation energy values of the inhibited corrosion reaction of mild steel are lesser than the value obtained for the blank. The adsorption mechanism was found to be chemiosorption. Kinetic and thermodynamic parameters were also evaluated.
Direct Sinus Lift and Immediate Loading of Dental Implant– Clinical Reports and Preliminary Radiographic Results

Edentulous posterior maxilla is the most challenging area for the implant placement. Because of increase pneumatization of sinus in this area available bone height is inadequate for primary stability of implants. Sinus lift procedure followed by floor augmentation is the only option to increase the availability of bone in this area. Sinus lift procedure can be direct or indirect type depending on available bone height. For augmentation of floor the grafting materials varies from Autogenous bone grafts to xenografts and alloplastic material. We can also use combination of these to increase the success rate. In our cases we used direct sinus lift with MILA SLA Kit and augmentation with Bone Plus TM bone graft with successful immediate implant placement by Anyridge Megagen company in Maxillofacial and Dental Department of M P Shah Hospital, Kenya.
Bilingual Acculturation Assessment: An Overview of Current Developments

Assessments are often used for decision-making in education, mental health practices, and industry. Consequently, decisions based on these assessments affect multiple aspects of a person’s life. Given the increase of ethnic minorities in the U.S., factors concerning the appropriateness and interpretation of tests based on norms must be reconsidered. The multifaceted effects of culture are just one factor to consider so as to not overlook important cultural components that may negatively impact the decision-making process. Additionally, language, with close ties to culture, must also be considered. Thus, the complexity of culture and language in tandem to assessment-based decision-making necessitates fundamental understanding of the effects of bilingual acculturation assessment development. A brief history of bilingual acculturation is considered. Careful consideration is given to bilingual acculturation assessment within the context of measurement development, empirical application, and validity issues. Implications and limitations of the current studies are discussed.
A Case of Hepatocellular Carcinoma with a Complete Response to Second-Line Chemotherapy with Ramucirumab

Introduction: Ramucirumab has become the standard of care in second-line systemic therapy for advanced Hepatocellular Carcinoma (HCC) (AFP ≥400 ng/ml). A Complete Response (CR) to systemic therapy is generally very rare. We encountered a patient who achieved CR to secondline therapy with ramucirumab. Case presentation: We herein report a case of a 62-year-old male diagnosed with HCC and lung metastases 6 months after liver surgery. AFP and PIVKA-II were elevated and his liver function was Child-Pugh A. Sorafenib at 800 mg as the first-line therapy was administered for 6 weeks, and after the progression of the first-line therapy ramucirumab was administered as second-line systemic therapy. The tumor decreased in size and this was judged to be a partial response. Due to the absence of recurrence for approximately 5 years after the cessation of treatment, the present case was considered to have achieved CR. Conclusion: We encountered a case of HCC with CR to second-line systemic therapy with ramucirumab after sorafenib. The high affinity of ramucirumab to vascular endothelial growth factor receptor 2 (VEGFR2) may have exerted additional anti-tumor effects in cases refractory to systemic therapy having anti-VEGF effects.
Targeting the Ubiquitin Proteasome System in Cancer

The ubiquitin proteasome system is involved in a myriad of biological functions including cell cycle progression, intracellular signaling and protein degradation. As such, it is not surprising to find many components of the system misregulated in cancer. The clinical success of Bortezomib for treatment of multiple myeloma proves that targeting the ubiquitin proteasome system is valid and feasible. Here, a detailed examination of the strategies used to target the ubiquitin proteasome system in cancer is discussed. The inhibitors available, its targets, the cancer type and the developmental stage it is in are discussed. conjugation cascade and inhibitors targeting specific cascade component.
Characterisation of novel paramyxoviruses isolated from pteropid bat urine

Bats are a significant source of zoonotic viruses including the highly pathogenic Hendra and Nipah viruses. Virus discovery efforts in bats have demonstrated many novel viruses but the zoonotic potential of many of these viruses remains unknown. This thesis describes the analysis of bat urine samples resulting in the detection of multiple viral sequences and the isolation of novel viruses. In addition, it details the characterisation of two novel paramyxoviruses, Teviot virus and Alston virus, through whole genome sequencing, analysis of antigenic relatedness, growth kinetics assays and animal infection trials.
Complicaciones por esterilización quirúrgica mediante ovariohisterectomía en perras: revisión sistemática

La ovariohisterectomía en perras es un procedimiento quirúrgico de esterilización frecuente. Sin embargo, se pueden presentar complicaciones a corto y largo plazo que son necesarias conocer. Esta revisión sistemática tiene como objetivo identificar las complicaciones por ovariohisterectomía en perras, analizando la calidad metodológica de los estudios que aportan estos datos. Se identificaron 40 estudios publicados en español, inglés y portugués mediante búsqueda electrónica en PubMed, Medwell Journals, SciELO, Science Direct y Google Académico. Se seleccionaron seis estudios descriptivos de complicaciones por ovariohisterectomía en perras. Se excluyeron los estudios sobre complicaciones con metodologías no comparables. Se apreció heterogeneidad en las características y calidad de los estudios. La mayoría utilizó muestreo por conveniencia, en el que el número de participantes varió entre los estudios desde 72 a 1880. Las unidades de análisis fueron hembras caninas de seis a 108 meses de razas puras y cruces. El periodo de seguimiento de los pacientes para la valoración de complicaciones varió desde una semana hasta diez años. La proporción de complicaciones se situó entre 0,1 y 74 %. Los principales eventos reportados son los que se presentan a corto plazo como las complicaciones anestésicas, hemorragias e inflamación de la herida; a largo plazo está la incontinencia urinaria, piómetra y obesidad. Se concluye que la evidencia científica disponible sobre complicaciones en perras esterilizadas mediante ovari ohisterectomía no es suficiente como respaldo para la toma de decisiones en la práctica clínica de esta especie respecto al tema abordado.