Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of calcium hydroxide on the apical microleakage of canals filled with bioceramic and resin sealers

Aim: To evaluate the impact of calcium hydroxide (Ca[OH]2) on the apical microleakage of canals filled with the bioceramic Total Fill BC (TF BC) and the resin AH 26 sealers. Methodology:A total of 104 human single-canal maxillary teeth were prepared with rotary files. The teeth were randomly divided into two main test groups (n=48) and two control groups, one positive and one negative (n=4). In one test group, Ca(OH)2 was used; in the other test group, no dressing was placed within the canal. Samples in each test group - with or without Ca(OH)2 dressing - were randomly divided into two subgroups. In one subgroup, AH 26 sealer was used and in the other one, TF BC sealer was used. The specimens with Ca(OH)2 were kept at 37 °C in 100% humidity. A dye penetration technique was used to evaluate the leakage. The data were analyzed by Kolmogorov-Smirnov, Kruskal-Wallis, Mann-Whitney U, and Fisher exact tests. Results: The mean microleakage in the subgroups filled with TF BC sealer, with or without Ca(OH)2, was significantly greater than that in the subgroups filled with AH 26 sealer. In addition, the microleakage of the TF BC specimens with Ca(OH2) was significantly higher than the microleakage of TF BC specimens without the dressing (P<0.001). Conclusion: The findings of this study showed that use of Ca(OH)2 as an intracanal dressing negatively affected the sealing potential of TF BC.
Avaliação sanitária e fisiológica de sementes de mogno e baru tratadas com captana

Mogno (Swietenia mahagoni, Meliaceae) e baru (Dipteryx alata, Fabaceae) são espécies arbóreas de grande importância econômica para produção de móveis de luxo, decoração, artesanato e alimentação. No entanto, a ação de patógenos associados às sementes pode causar redução em populações dessas espécies. Tratamentos com fungicidas constituem-se em uma medida segura e de baixo custo para o controle de fungos associados às sementes. Dessa forma, o objetivo do trabalho foi avaliar a influência de diferentes doses de fungicidas na qualidade fisiológica e sanitária de sementes de mogno e baru. As sementes foram tratadas com três doses do fungicida Captan® (0,1; 0,3 e 0,5 g/ 100 g de sementes). As avaliações sanitárias foram realizadas a partir de testes em caixas de poliestireno cristal (gerbox) forrado com papel filtro, mostrando os diferentes efeitos nas sementes das espécies analisadas. O tratamento químico proporcionou uma redução na incidência de fungos associados às sementes de baru, recomendando-se o uso deste princípio ativo para o tratamento de sementes dessa espécie. Apesar de ser recomendado para o tratamento de sementes de baru, o tratamento químico influenciou negativamente no desenvolvimento das sementes de mogno, prejudicando a germinação devido provavelmente a penetrância do produto através do tegumento, influenciando negativamente no desenvolvimento do embrião.
Exploring the Socio-Economic Experiences of Women Post-Mastectomy in the Tamale Metropolis

Background: Breast cancer (BC) is the most commonly diagnosed cancer among females. Mastectomy is the treatment of choice in most African countries due to late reporting. The majority of women diagnosed with BC experience socio-economic challenges. This study explored the factors that affect the socio-economic well-being of women post-mastectomy in Ghana. Methods: The study was conducted at the teaching hospital in the northern region of Ghana using descriptive exploratory qualitative design. A purposive sampling method was employed to recruit participants. Data was saturated with 15 participants aged between 28 and 78 years. The in-depth interviews were recorded and transcribed verbatim. Data were analyzed using thematic content analysis procedures. Results: Participants isolated themselves as society frown on them after mastectomy. Some of the women loss their jobs/businesses and some did not get the needed support. The high cost of treatment placed a huge financial burden on them. Some of the participants felt rejected and loss their femininity, as their partners were not having sex with them after the operation. Conclusion: Women post mastectomy faces several challenges and family support is vital to improve their wellbeing. There is a need to educate the public against the stigmatization of women post mastectomy.
Corrosion of calcareous stones in humid air containing SO 2 and NO 2

Samples of limestone, marble and travertine were exposed to mixtures of sulphur dioxide and nitrogen dioxide gases in humid air. A strong synergistic effect on corrosion was found when the gases were combined. Sulphur dioxide alone causes the formation of calcium sulphite while in the presence of nitrogen dioxide as well, the sulphate (gypsum) is produced the mexhanism of deposition and the catalytic oxidation of suuphur dioxide are discussed.
Leisure Spending Patterns and their Relationship with Mental Health in the Elderly in Iran

Objectives: Older adults need vitality to survive. Entertainment and activity for the elderly creates a lively life, boost their self-esteem, and saves them from being inactive and unproductive, which will ultimately improve their mental health. This study aims was to determine the relationship between leisure spending patterns and mental health in the elderly Methods & Materials: This descriptive-analytical study was carried out on 413 elderly people aged ≥60 years, who were selected using a cluster random sampling method from four districts of Tehran, Iran. Data were collected using the standard General Health Questionnaire, and a researcher-made Leisure Spending Scale. The collected data were analyzed in SPSS V. 21 software using descriptive statistics (frequency, standard deviation) and statistical tests including Spearman correlation test and regression analysis. Results: The most frequent leisure activity was TV watching. There was a significant relationship between recreational and religious activities of elderly and their mental health (P<0.0001). Among the confounding factors, physical health had the most impact. Conclusion: Given the significant relationship of recreational and religious activities with the mental health of the elderly, planners should take the role of mosques, ḥosayniyas, and leisure facility providers such as municipalities, seriously. On the other hand, considering the impact of physical health on the relationship of leisure spending with mental health, it is necessary to provide opportunities to the elderly to participate in sports and recreational activities.
An Approach to Grade Aggregates having Mild Potential Alkali - Silica Reactivity

In many parts of the world concrete structures have failed due to Alkali-Aggregate Reaction (AAR). Researchers have explored remedial actions to be taken and mitigation techniques to be followed in concrete construction to alleviate the problem of AAR. In Sri Lanka, so far no documented evidence has been produced about investigations of this nature though there are a few old concrete structures which are still being used but showing symptoms similar in nature to AAR. To investigate the potential alkali-silica reactivity of Sri Lankan aggregates, preliminary work has been attempted. A quick chemical method which is used in many countries has been used to test fine and coarse aggregates collected from different locations in the country. According to the results, many aggregates can be placed in the non-reactive zone of the chart of innocuous and deleterious aggregates illustration of ASTM C 289. But some fall in a gray area close to the boundary of the demarcation of reactivity, which could be defined as a ‘slowly reactive’ zone. Having recognized the significance of quantifying the degree of reactivity of such slowly reactive aggregates, a new parameter called ‘potential reactivity index’ has been introduced. This index may serve the process of screening aggregates for structures of long life expectancies.
Increased Expression of DNA Methyltransferase 1 and 3B Correlates with Tumor Grade in Laryngeal Squamous Cell Carcinoma

Background: DNA methyltransferase (DNMT) enzymes, encoded by DNMT1, DNMT3A andDNMT3B genes, play a major role in the development of cancers through aberrant promotermethylation. Due to little information about the biological and clinical significance of expressionchanges of these genes in Laryngeal Squamous Cell carcinoma (LSCC), the current study wasdesigned to evaluate the contribution of DNMTs expression as potential diagnostic biomarkersin progression of LSCC. Methods: DNMT1, DNMT3A and DNMT3B expressions in tumoral and normal tissues fromthirty-three LSCC patients were evaluated by relative comparative real-time PCR, prior toany therapeutic intervention. Relationship between genes expression and clinicopathologicalfeatures were also analyzed. Results: The mRNA expression levels of all three DNMTs (DNMT1, DNMT3A and DNMT3B)were significantly elevated in LSCC tumor specimens compared to that of non-tumor tissues(P<0.0001, P=0.011 and P<0.0001, respectively). The expression of DNMT1 and DNMT3Bwas strongly associated with histopathological tumor grade. Moreover, the mRNA expressionlevels of DNMT3A were significantly correlated with laryngopharyngeal reflux. No significantrelationships existed with other clinicopathological parameters. Conclusion: Data showed that the expression levels of DNMT1, DNMT3A and DNMT3Bmarkedly increased in LSCC tissues. DNMT1 and DNMT3B were mainly overexpressed in highgrade LSCC tumors, therefore, they may have a role in LSCC progression. It seems that thesegenes may serve as diagnostic biomarkers in development of LSCC.
Functional conservation and divergence of five AP1/FUL-like genes in Marigold (Tagetes erecta)

Background: Members of AP1/FUL subfamily genes play an essential role in the regulation of floral meristem transition, floral organ identity, and fruit ripping. At present, there have been insufficient studies to explain the function of the AP1/FUL-like subfamily genes in Asteraceae. Results: Here, we cloned two euAP1 clade genes TeAP1-1 and TeAP1-2, and three euFUL clade genes TeFUL1, TeFUL2, and TeFUL3 from marigold (Tagetes erecta). Expression profile analysis demonstrated that TeAP1-1 and TeAP1-2 were mainly expressed in receptacles, sepals, petals, and ovules. TeFUL1 and TeFUL3 were expressed in floral buds, stems and leaves as well as in productive tissues, while TeFUL2 was mainly expressed in floral buds and vegetative tissues. Transgenic Arabidopsis lines showed that overexpression TeAP1-2 or TeFUL2 resulted in early flowering, implying that these two genes might regulate the floral transition. Yeast two-hybrid analysis indicated that TeAP1/FUL proteins only interacted with TeSEP proteins to form heterodimers, and that TeFUL2 could also form a homodimer.Conclusion: In general, TeAP1-1 and TeAP1-2 might play a conserved role in regulating sepal and petal identity, just like the role of MADS-box class A genes, while TeFUL genes might display divergent functions. This study provides an insight into molecular mechanism of AP1/FUL-like genes in Asteraceae species.
Trazodone Not Only A Stabilizer in Allergic Rhinitis

We report the case of a 44 years old woman referred to the outpatient Sleep Disorder Service of the Neurological Clinic, Marche Polytechnic University for a symptomatology characterized by difficulty in maintaining sleep and a feeling of unrefreshing sleep on waking. On clinical history, she referred an allergic rhinitis, treated with short cycles of inalatory steroids and vasoconstrictors. At the moment of our observation, she did not assume any treatment [1]. Due to the reported symptoms, particular attention was paid to the possible presence of sleep disturbances, in particular sleep-related breathing disorders. In this respect, patient reported a morning dry mouth. Further, the partner referred an important snoring and continuous lightening of sleep. Nocturnal apnea events were not reported as well as discomfort or abnormal movements in the legs. No other disturbance suggestive for NREM or REM sleep disturbances, nor fewer specific phases were evidenced. Patient was then submitted to a polygraphy which showed a rhonchopathy associated with air flow limitations, a high arousal index and elevated heart rate variability. The exam excluded periodic limb movements (Figure 1) [2,3]. Considering the history of allergic rhinitis and also to evaluate the possible presence of anomalies of the upper airways, an ENT assessment was indicated. Further, in relation to the difficulty in maintaining sleep and for the high indices of autonomic dysfunction, a pharmacological treatment with trazodone at the dose of sleep stabilizer, 30 mg in the evening was prescribed.
Fractal dimension of phylogenetically different parts of the human cerebellum (magnetic resonance imaging study)

In recent years, fractal analysis has been increasingly used as a morphometric method, which allows to assess the complexity of the organization of quasi-fractal biological structures, including the cerebellum. The aim of the study was to determine the value of fractal dimension of phylogenetically different parts of the cerebellum by studying magnetic resonance imaging of the brain using the method of pixel dilation and to identify gender and age characteristics of individual variability of fractal dimension of the cerebellum and its external linear contour. The study was performed on the magnetic resonance images of the brain of 120 relatively healthy patients in age 18-86 years (65 women, 55 men). T2 weighted tomographic images were investigated. Fractal analysis was performed using the method of pixel dilation in the author’s modification. Fractal dimension (FD) values were determined for cerebellar tomographic images segmented with brightness values of 100 (FD100), 90 (FD90) and in the range of 100-90 (FD100-90 or fractal dimension of the outer cerebellar contour) in its upper and lower lobes, which include phylogenetically different zones. The obtained data were processed using generally accepted statistical methods. The average value of FD100 of the upper lobe of the cerebellum was 1.816±0.005, the lower lobe – 1.855±0.005. The average value of FD90 of the upper lobe of the cerebellum was 1.734±009, the lower lobe – 1.768±0.009. The average value of FD100-90 of the upper lobe of the cerebellum was 1.370±0.009, the lower lobe – 1.431±0.008. All three values of the fractal dimension of the lower lobe, which lobules have a lower phylogenetic age, are statistically significantly higher than the corresponding values of the fractal dimension of the upper lobe, have a more pronounced correlation with age than in the upper lobe. The developed research algorithm can be used to assess the condition of the cerebellum as an additional morphometric method during magnetic resonance imaging study of the brain.
Detecting Drug-Drug Interaction (DDI) over the Social Media using Convolution Neural Network Deep Learning

Drug-Drug Interaction (DDI) detection is a challenging problem for drug manufacturers, drug regulatory authorities, and medical professionals alike. It is impossible to run trials or be aware of every single case involving an entire population. Research in the use of social media data is currently gaining attention, and with the application of machine learning techniques has been successfully applied in businesses. This paper presents a project extracting DDI from biomedical text using a Convolutional Neural Network (CNN) classifier. The classifier is trained on the SemEval 2013 DDIExtraction challenge dataset and aims to automatically learn the best feature representation on the input of the given task. Different models have been proposed, which make use of position embeddings in combination with word embeddings trained on the machine learning model to learn features. Word embeddings are necessary for providing dense vector representation of words that can be trained, but a large amount of data is required to train an effective vector representation of words. To compensate for the lack shortage of data, the CNN model is trained on a pre-trained PubMed word embedding, which provides a vector dimension of size 200 for the representation of each word. This project aims to provide a trained CNN model for which vector representation of words is provided by weights that have been trained for medical text classification purposes.
AKTIVITAS ANTIHIPERPIGMENTASI LIKOPEN SECARA IN SILICO

Hiperpigmentasi disebabkan oleh terakumulasinya melanin yang berlebihan pada kulit sehingga terjadi penggelapan kulit. Hiperpigmentasi ini salah satu penyebab orang kurang percaya diri, sehingga produk kosmetik dipasaran menawarkan solusi antihiperpigmentasi. Senyawa yang umum digunakan pada produk antihiperpigmentasi adalah hidrokuinon Permasalahan penggunaan hidrokuinon terletak pada efek samping yang ditimbulkan yaitu okronosis, genotoksisitas, dan karsinogenik. Tujuan penelitian ini untuk mengetahui potensi likopen sebagai antihiperpigmentasi secara in silico dengan mekanisme penghambatan tirosinase dibandingkan dengan hidrokuinon. Metode yang digunakan adalah molecular docing. Analisis data dilakukan dengan membandingkan energi ikatan yang diperoleh dari likopen dan hidroquinone yang di-docking-kan dengan tirosinase. Energi ikatan dari kedua senyawa tersebut dengan tirosinase secara berturut-turut adalah -5,18 dan -4,22. Nilai energi ikatan tirosinase lebih rendah dibandingkan dengan hidrokuinon. Perbandingan energi ikatan dari likopen dan hidroquinone menunjukkan bahwa likopen merupakan senyawa yang memiliki potensi sebagai inhibitor tirosinase secara in silico dengan aktivitas yang lebih tinggi dibandingkan dengan hidrokuinon. Kata kunci: Hiperpigmentasi, Hidrokuinon, Likopen, In Silico
Avaliação Dinâmica de um Sistema Elétrico em Cenário de Estiagem

The present work intends to analyze the transient and dynamic behavior of an electrical network that contains a steam thermal plant, a hydroelectric plant and a wind farm. The work started from the hypothesis that in a drought scenario with little hydro generation, less rotating mass, the system would be more vulnerable to disturbance. In this case, the disturbances suffered by the system were the short circuit and the load cut in four simulation scenarios: Normal, Hydro reduction, Thermal reduction and Hydro reduction with thermal increase. The behavior of the waveforms of the rotor speed of the induction generator and the synchronous one as a function of time will be shown and the veracity of the initial hypothesis will be proven. Resumo: O presente trabalho pretende analisar o comportamento transitório e dinâmico de uma rede elétrica que contém uma usina Térmica a vapor, uma usina Hidrelétrica e um parque eólico. O trabalho partiu da hipótese de que em um cenário de seca com pouca geração hídrica, menos massa girante, o sistema estaria mais vulnerável a perturbação. Nesse caso, as perturbações sofridas pelo sistema foram o curtocircuito e o corte de carga em quatro cenários de simulação: Normal, Redução de hídrica, Redução de térmica e Redução de hídrica com aumento de térmica. Serão mostrados os comportamentos das formas de onda da velocidade do rotor do gerador de indução e do síncrono em função do tempo e comprovado a veracidade da hipótese inicial.
Numerical Investigation of the Effect of Flutter Instability of the Blade on the Unsteady Flow in a Modern Low-Pressure Turbine

Modern aeronautical Low-Pressure Turbines (LPTs) are prone to aeroelastic instability problems such as flutter. The aerodynamic performance of a modern LPT is often influenced by the interaction between the transient flow and the dynamic behaviour of the blade. Therefore, the investigation and understanding of the physics behind the interaction between the unsteady flow and the flutter phenomenon of the blade in an LPT, which is normally left out by existing studies, is an important aspect of the research to improve the aerodynamic performance of the turbine as well as to ensure the blade mechanical integrity. In this paper, a novel analysis is conducted to explore the flutter instability in a modern LPT, T106A turbine, using two inter blade phase angles (IBPAs), and their effects on the unsteady flow field are investigated. The zero degree and 180 degrees IBPAs are considered in this paper. A high-fidelity direct numerical simulation method is used for the flow simulations. Another distinctive feature of this paper is the use of the 3D model to analyse the effects associated with the 3D blade structure and the 3D vibration mode. The investigation and identification of adequate working ranges of the harmonic balance method, which has been widely used for the aeromechanical analysis of turbomachines, are also presented in this work. This paper will bridge a key gap in the knowledge of aeroelasticity modelling and analysis of modern LPTs.
Isolation of Murine Myeloid Progenitor Populations by CD34/CD150 Surface Markers

Myeloid progenitors are intermediates between Hematopoietic Stem Cells (HSCs) and Myeloid effector progeny. In mouse bone marrow, they are part of the Lineage− cKit+ Sca1− (LK) compartment. To date, most researchers used CD34 and FcγR surface markers for the dissection of this compartment into various populations. Surprisingly, however, this approach does not provide distinct separation by fluorescence-activated cell sorting (FACS). In this study, we suggest using CD150 instead of FcγR. We re-analyzed published single-cell RNA-Seq data and found that CD34/CD150 provides better sub-populations separation, compared to the “classical” CD34/FcγR-based approach. We confirm our findings by independent FACS analysis. We demonstrate comparable differentiation potential of the newly-obtained LK sub-populations, like previous “classical” ones. Therefore, we suggest the CD34/CD150 gating strategy, utilizing commonly-used surface markers, as a robust and reproducible separation of the LK compartment into distinct sub-populations.
Massive MIMO for 5G and beyond

Massive multiple -input multiple -output (MIMO) is one of the key technologies for fifth generation (5G) and beyond [1]. By utilizing a large number of antennas, it can significantly improve the spectrum efficiency and is promising to achieve 5G key performance indicators. However, the application of large-scale antenna arrays leads to new challenges for physical layer signal processing. In this chapter, we will focus on massive MIMO systems and give a comprehensive introduction on massive MIMO technology for 5G and beyond.