Miracle-dz/UniFAR-FTUs huggingface dataset:
A gene causing ocular retardation in the mouse.

In 1955 three mice with very small eyes were observed in a stock segregating for the gene Patch . These animals all came from the same mating and on investigation proved to be homozygous for a new gene causing a reduction in the blood-supply of the eyes at a critical embryonic stage. The original animals where also Ph /+, but this gene was soon eliminated from the new stock and had nothing to do with the size of the eyes. A segregating litter of these mice was given to Dr. B. V. Konyukhov of oscow in 1959 for immunological studies on the development of the lens. Since then Dr. Konyukhov (1961) has carried out genetical (Konyukhov & Glukharev, 1961) and embryological investigations which have partly duplicated the present work. Unfortunately, Dr. Konyukhov has used the unofficial laboratory name of ‘blind’ (symbol bl ) for the mutant.
SSLLE: Semi-supervised Locally Linear Embedding based Localization Method for Indoor Wireless Networks

Due to vast applications of mobile devices and local area wireless networks, location based services are popularized and location information use has become important . The paper proposes a method based on Semisupervised Locally Linear Embedding for localization in indoor wireless networks. Previous methods for location estimation in indoor wireless networks require a large amount of labeled data for learning the radio map. However labeled instances are often difficult, expensive, or time consuming to obtain, as they require great efforts, meanwhile unlabeled data may be relatively easy to collect. So the use of semi-supervised learning is more feasible. In the experiment 101 access points (APs) have been deployed so the Received Signal Strength (RSS) vector received by the mobile station has large dimensions (i.e.101). First we have used Locally Linear Embedding, a dimensional reduction technique to reduce the dimensions of data, and then we have used semi-supervised learning algorithm to learn the radio map. The algorithm performs nonlinear mapping between the received signal strengths from nearby access points and the user’s location. It is shown that the proposed scheme is easy in training and implementation. Experimental results are presented to demonstrate the feasibility of the proposed SSLLE algorithm.
Encryption and Data Management Architecture to Protect Biometric Security

In this paper, a novel symmetric encryption algorithm and its data management architecture to protect biometric security and privacy is proposed. Unlike current biometric encryption, the proposed method uses cryptographic keys in conjunction with extracted MultiBiometrics to create cryptographic bonds. To further enhance the security protection and to improve authentication accuracy, a data management architecture is being developed. The proposed method is being tested on images from three public databases: the “Put Face Database”, the “Indian Face Database”, and the “CASIA Fingerprint Image Database Version 5.1”. The performance of the proposed solution has been evaluated using the Equal Error Rate (EER) and Correct Recognition Rate (CRR). The experimental results demonstrate the effectiveness of the proposed method.
The Effect of Laser Sintering Process Parameters on Cu Nanoparticle Ink in Room Conditions

Copper is an interesting material for printed electronics inks because, for example, of its good conductivity and lower raw material price compared to silver. However, post-processing Cu inks is challenging because of non-conductive copper oxide. In this work, inkjet-printed Cu nanoparticle structures were sintered on a polyimide substrate with a continuous-wave 808-nm diode laser. Laser sintering was tested by varying the sintering parameters (optical power and scanning velocity), and the electrical resistance of the samples was measured. A minimum sheet resistance of approx.90 mΩ/□ was obtained. All tests were run in room conditions. Sintered structures were then analyzed from SEM images. Results showed that laser sintering produces good repeatability, that a scanning velocity increment positively affects the process window, and that multiple sintering cycles do not increase conductivity.
Performance from Aligning Smalltalk & Javascript Classes

Amber is a wonderful Smalltalk programming environment that runs on top of Javascript, including a browser-based IDE and compiler, as well as command-line support. The only challenge is that execution performance can be 1--2 orders of magnitude slower than native Javascript code. Amber-Direct is a series of modest changes to the compiler and some infrastructure classes and methods that bring most generated programs to within a factor of two of native Javascript. The challenge we faced was maintaining a seamless integration into existing Javascript classes while maximizing fidelity to Smalltalk execution semantics.
Slow-Wave Broadside-Coupled Microstrip Lines and Its Application to the Rat-Race Coupler

This letter proposes a type of slow-wave broadside-coupled microstrip lines. The new structure only requires a single-layer substrate and has the independently controllable even- and odd-mode impedances and slow-wave factors by adjusting the corresponding structural parameters. This property greatly simplifies the circuit design. In addition, it provides a large coupling strength. A miniaturized wideband microstrip rat-race coupler with the high isolation and perfect balances is implemented using the proposed slow-wave coupled lines.
Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters

Summary Emerging evidence supports a role for platelets in the progression of atherosclerosis in addition to an involvement in thrombotic vascular occlusion. Platelet Factor 4 (PF4), a chemokine released by activated platelets, stimulates several pro-atherogenic processes. Therefore, we examined the localization of PF4 and the homologous protein, Neutrophil Activating Protein-2 (NAP-2) in lesions representing the evolution of human atherosclerotic plaques. Carotid plaques from 132 patients with critical carotid stenosis and 6 autopsy specimens were studied. Clinical, histologic and immunohistochemical data were analyzed using a χ2-test. PF4 was detected in the cytoplasm of luminal and neovascular endothelium, in macrophages and in regions of plaque calcification. The presence of PF4 in macrophages and neovascular endothelium correlated with lesion grade (p = 0.004; p = 0.044). Staining of macrophages for PF4 correlated with the presence of symptomatic atherosclerotic disease (p = 0.028). In early lesions, PF4 was commonly found in macrophages of early lesions (Grade I/II), whereas NAP-2 was rarely present. In conclusion, correlation between PF4 deposition, lesion severity and symptomatic atherosclerosis suggests that persistent platelet activation may contribute to the evolution of athero-sclerotic vascular lesions. These studies support the rationale for the chronic use of anti-platelet therapy in patients at risk for developing symptomatic atherosclerosis.
Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.

A long-standing problem in developmental biology has been to understand how the embryonic germ layers gain the competence to differentiate into distinct cell types. Genetic studies have shown that members of the GATA and HNF3/fork head transcription factor families are essential for the formation and differentiation of gut endoderm tissues in worms, flies, and mammals. Recent in vivo footprinting studies have shown that GATA and HNF3 binding sites in chromatin are occupied on a silent gene in endoderm that has the potential to be activated solely in that germ layer. These and other data indicate that these evolutionarily conserved factors help impart the competence of a gene to be activated in development, a phenomenon called genetic potentiation. The mechanistic implications of genetic potentiation and its general significance are discussed.
Telehealth in palliative care in the UK: a review of the evidence

We reviewed telehealth applications which were being used in palliative care settings in the UK. Electronic database searches (Medline, CINAHL, PsychInfo and Embase), searches of the grey literature and cited author searches were conducted. In total, 111 papers were identified and 21 documents were included in the review. Telehealth was being used by a range of health professionals in oncology care settings that included specialist palliative care, hospices, primary care settings, nursing homes and hospitals as well as patients and carers. The most common applications were: out-of-hours telephone support, advice services for palliative care patients, carers and health professionals, videoconferencing for interactive case discussions, consultations and assessments, and training and education of palliative care and other health-care staff. The review suggests that current technology is usable and acceptable to patients and health professionals in palliative care settings. However, there are several challenges in integrating telehealth into routine practice.
Harmonic analysis of power system signals using a new regularized adaptive windowed Lomb periodogram

This paper proposes a new regularized adaptive windowed Lomb periodogram (RAWLP) method for time-frequency analysis of non-stationary power signals. It extends the conventional Lomb periodogram by estimating the periodogram locally using the weighted least-squares (WLS) estimator. Instead of employing one constant window in WLS, variable window bandwidth is adaptively selected by the intersection of confidence intervals (ICI) method to achieve a better tradeoff between time resolution and frequency resolution. Furthermore, regularization techniques are incorporated in the AWLP to further improve its performance by reducing the variance of the estimator. Simulation results show that the proposed RAWLP method has superior performance over windowed Lomb periodogram with one constant bandwidth for estimating the harmonic and interharmonic frequencies in power systems.
Organizational Culture and Knowledge Sharing Behavior: Examining Serial Mechanisms

This study aims to examine how hierarchy organizational culture affect the knowledge sharing behavior of teachers in higher education institutions and universities and its mediated link through formal knowledge governance mechanism and knowledge sharing opportunity. A sample of 269 teachers was drawn from university teachers in Pakistan and structural equation modeling is used to test the hypotheses. The results of this study suggest that first, hierarchy organizational culture is positively associated with knowledge sharing behavior of teachers. Second, formal knowledge governance mechanism fully mediated the relationship between hierarchy organizational culture and knowledge sharing behavior. Third, knowledge sharing opportunity fully mediated the relationship between hierarchy organizational culture and knowledge sharing behavior. Finally, the relationship between hierarchy organizational culture and knowledge sharing behavior is sequentially and fully mediated by formal knowledge governance mechanism and knowledge sharing opportunity. Theoretical and managerial implications are discussed followed by limitations of the study along with suggestions for future research.
Design Choice in 45-nm Dual-Port SRAM - 8T, 10T Single End, and 10T Differential

As process technology is scaled down, a large-capacity SRAM will be used. Its power must be lowered. The Vth variation of the deep-submicron process affects the SRAM operation and its power. This paper compares the macro area, readout power, and operating frequency among dual-port SRAMs: an 8T SRAM, 10T single-end SRAM, and 10T differential SRAM considering the multi-media applications. The 8T SRAM has the lowest transistor count, and is the most area efficient. However, the readout power becomes large and the access time increases because of peripheral circuits. The 10T single-end SRAM, in which a dedicated inverter and transmission gate are appended as a single-end read port, can reduce the readout power by 74%. The operating frequency is improved by 195%, over the 8T SRAM. However, the 10T differential SRAM can operate fastest (256% faster than the 8T SRAM) because its small differential voltage of 50mV achieves high-speed operation. In terms of the power efficiency, however, the readout current is affected by the Vth variation and the timing of sense cannot be optimized singularly among all memory cells in a 45-nm technology. The readout power remains 34% lower than that of the 8T SRAM (33% higher than the 10T single-end SRAM); even its operating voltage is the lowest of the three. The 10T single-end SRAM always consumes less readout power than the 8T or 10T differential SRAM.
Implementation of evidence-based employment services in specialty mental health.

OBJECTIVE Study a quality improvement approach for implementing evidence-based employment services at specialty mental health clinics. DATA SOURCES/STUDY SETTING Semistructured interviews with clinicians and administrators before, during, and after implementation. Qualitative field notes, structured baseline and follow-up interviews with patients, semistructured interviews with patients after implementation, and administrative data. STUDY DESIGN Site-level controlled trial at four implementation and four control sites. Hybrid implementation-effectiveness study with mixed methods intervention evaluation design. DATA COLLECTION/EXTRACTION METHODS Site visits, in-person and telephone interviews, patient surveys, patient self-assessment. A total of 801 patients completed baseline surveys and 53 clinicians and other clinical key stakeholders completed longitudinal qualitative interviews. PRINCIPAL FINDINGS At baseline, sites varied in the availability, utilization, and quality of supported employment. Each site needed quality improvement for this service, though for differing reasons, with some needing development of the service itself and others needing increased service capacity. Improvements in knowledge, attitudes, beliefs, and referral behaviors were evident in mid- and postimplementation interviews, though some barriers persisted. Half of patients expressed an interest in working at baseline. Patients at implementation sites were 2.3 times more likely to receive employment services during the study year. Those who had a service visit were more likely to be employed at follow-up than those who did not. CONCLUSIONS Studies of implementation and effectiveness require mixed methods to both enhance implementation in real time and provide context for interpretation of complex results. In this study, a quality improvement approach resulted in superior patient-level outcomes and improved clinician knowledge, attitudes, and behaviors, in the context of substantial variation among sites.
Attention-deficit hyperactivity disorder and problems in peer relations: predictions from childhood to adolescence.

OBJECTIVE To determine whether childhood attention-deficit hyperactivity disorder (ADHD) and persistence of the disorder are associated with later difficulty in adolescent peer relations. METHOD One hundred eleven children with ADHD were interviewed as adolescents and compared with 100 adolescents without an ADHD history (aged 13-18 years). The multi-informant assessment strategy included parents, teachers, and adolescents. RESULTS Parents of probands reported fewer close friendships and greater peer rejection compared with the non-ADHD group. Probands reported that their friends were less involved in conventional activities compared with the non-ADHD group. Childhood aggression predicted less self-perceived social competence for probands. The long-term effects of ADHD on social functioning were more pronounced for probands with persistent ADHD or conduct disorder in adolescence. CONCLUSIONS Impairments in peer relations for ADHD youths, known to be common in childhood, also exist in adolescence. Given the developmental significance of peer relations, further research into the causes and treatment of poor social functioning in youths with ADHD is recommended.
The Design of a Risk-Based Performance Audit Program for Court-Fee Management for the Comptroller of Supreme Court of Indonesia

This research aimed to design a risk-based performance audit program for court-fee management for the comptroller of the Supreme Court of Indonesia by analyzing the implementation of the existing audit-planning process. This research is qualitative research with descriptive analysis. It used responses from people in the comptroller’s office to analyze the existing audit-planning process and use responses from court-fee managers at district courts to analyze the court-fee management. The initial results showed that, although the comptroller has limited resources, the existing audit-planning process has not fully used the risk base. Therefore, in this research, we proposed an audit program using a full-risk basis. The district courts do not have a risk register for court-fee management. Therefore, we facilitated the creation of a risk register for court-fee management using the previous audit reports and the responses of risk owners. We further determined the audit objective, audit scope, audit criteria, and audit procedures as components of an audit program using mind mapping based on the risk register. Finally, this research produced a risk-based performance audit program for the comptroller in the face of resource constraints.
Process Evaluation of a Nurse-Delivered Smoking Relapse Prevention Program for New Mothers

The objective of this study1 is to evaluate the feasibility, recall, and acceptability of an evidence-based intervention using home-health nurses to provide smoking relapse prevention skills to new mothers. The design of this study is process evaluation. Setting and participants include women who had delivered a normal newborn at a university hospital, who quit smoking during pregnancy, were smoke free for 7 days, and had saliva cotinine of less than or equal to 14 nanogram/ml. The intervention is a multicomponent cognitive-behavioral intervention, including inpatient contact, a home-health visit, and 2 follow-up phone calls. Results are as follows: 121 participants enrolled, and the intervention was implemented in 78 home visits. Nurses discussed tobacco issues for an average of 12.0 min. Almost all participants recalled the home visit; nearly two thirds recalled discussing tobacco use. Only 4% reported negative feelings toward discussing tobacco issues. In 87% of home visits, nurses implemented all 5 intervention components with self-reported nonsmokers. The conclusion is as follows: A nurse-delivered smoking relapse prevention intervention for new mothers was feasible and acceptable.
The Effectiveness of Self-Supporting Housing Stimulant Assistance Program on Feasibility of Low-Income People House in Daerah Istimewa Yogyakarta

Home is a main commodity. The goverment must guarantee its implementation. In fact, there are still many Indonesian's citizen who have not been able to own a house. The goverment has a role in providing it through the Self-Supporting Housing Stimulant Assistance Program.This program has the purpose and objective to increase the MBR initiative in the development / improvement of the quality of homes and buildings for decent housing. The purpose of this study is to assess the effectiveness of that program and find the factors that influence it. Descriptive and inferential statistical techniques are used in this study. A total of 314 samples were taken through combined sampling method that combines proportional and stratified sampling. Assessment of program effectiveness is processed with descriptive statistics while testing the factors that influence the decent of a home is carried out by binomial logistic regression. The results showed that the Self-Supporting Housing Stimulant Assistance Program was effective in realizing a decent home for MBR in Yogyakarta. However, improvements in some aspects are still needed. This program is also effective in realizing the self-supporting of the role of community groups so that it can support the realization of a decent house. However, this program cannot be said to be effective in growing selfsupporting in terms of development funds. In other words, this program has not been sufficiently capable to stimulate the community in seeking additional development funds for themselves. This condition needs to be watched out as a negative indication that needs to be anticipated early. There are only three factors that are significant in influencing the eligibility of a Low-Income people home in DIY, namely the land ownership factor, the availability of the bathroom, and the availability of a family room. Even so, other factors cannot be concluded that it has no effect. This is made possible by the correlation with other independent variables. Keywords— Self-supporting housing stimulant assistance program, effectiveness, decent home, community self-supporting.
Chemical Constituents of Teucrium polium L. var. mollissimum Hand-Mazz

A new neo-clerodane type diterpenoid, Syrapolin II 1 (12,18-diacetoxy-15,16-diepoxy-6oxo-neo-cleroda-13(16),14-diene-3β,7α-20β-trihydroxy-19-hemiacetal) 1, and tow known compounds 6'-O-Caffeoyl-8-O-acetylharpagide 2, clerosterol-3-O-glucoside 3, were isolated from the aerial parts of Teucrium polium L. var. mollissimum Hand-Mazz. The structure of compounds were proposed on the basis of spectroscopic methods (IR, MS, NMR), and comparison with closely related compounds.
SWI/SNF Stimulates the Formation of Disparate Activator-Nucleosome Complexes but Is Partially Redundant with Cooperative Binding*

To investigate the potential mechanisms by which the SWI/SNF complex differentially regulates different genes we have tested whether transcription factors with diverse DNA binding domains were able to exploit nucleosome disruption by SWI/SNF. In addition to GAL4-VP16, the SWI/SNF complex stimulated nucleosome binding by the Zn2+ fingers of Sp1, the basic helix-loop-helix domain of USF, and the rel domain of NF-κB. In each case SWI/SNF action resulted in the formation of a stable factor-nucleosome complex that persisted after detachment of SWI/SNF from the nucleosome. Thus, stimulation of factor binding by SWI/SNF appears to be universal. The degree of SWI/SNF stimulation of nucleosome binding by a factor appears to be inversely related to the extent that binding is inhibited by the histone octamer. Cooperative binding of 5 GAL4-VP16 dimers to a 5-site nucleosome enhanced GAL4 binding relative to a single-site nucleosome, but this also reduced the degree of stimulation by SWI/SNF. The SWI/SNF complex increased the affinity of 5 GAL4-VP16 dimers for nucleosomes equal to that of DNA but no further. Similarly, multimerized NF-κB sites enhanced nucleosome binding by NF-κB and reduced the stimulatory effect of SWI/SNF. Thus, cooperative binding of factors to nucleosomes is partially redundant with the function of the SWI/SNF complex.