Miracle-dz/UniFAR-FTUs huggingface dataset:
Mobile Tracking for Mental Health and Wellbeing

In western countries, up to 30% of young people experience mild, moderate or more severe depressive symptoms by 18 years of age (Lewinsohn, Hops, Roberts, Seeley, & Andrews, 1993; Rushton, Forcier, & Schectman, 2002). Mild symptoms can progress to moderate and then severe symptoms (Rushton et al., 2002), resulting in diagnosable mental health disorders. Therefore, there is a substantial need for prevention programs that are simple and low-cost. These programs are fundamental to reducing the economic and personal burden of depression (Andrews, Sanderson, Corry, & Lapsley, 2000). Using a stepped care model may reduce the disease burden of mental illness, beginning with simple and inexpensive prevention programs (that occur before the onset of diagnosed disorders) and ‘stepping up’ to higher intensity programs as needed (Geisner, 2006; Jorm & Griffiths, 2006; van Straten, Seekles, Beekman, & Cuijpers, 2010). The stepped-care model has the advantage of providing low intensity early intervention programs with reduced length and cost of the treatment to young people experiencing mild mental health symptoms (Kuehner, Huffziger, & Liebsch, 2009; Lynch et al., 2005; Spence et al., 2005). van Straten et al. (2010) advocate the use of ‘watchful waiting’ with young people experiencing mild mental health problems as a first step in the stepped care model. Current universal prevention programs that focus on intensive computerised or school-based cognitive behavioural therapy-based programs, such as the beyondblue Schools Research Initiative (Spence, Sheffield, & Donovan, 2003) are costly, time-consuming, have high attrition rates and therefore may be better suited to second-step early intervention targeting young people with elevated symptomatology. Third-step interventions should involve individualised face-to-face therapy with young people experiencing diagnosed disorders. Fourth-step interventions could then involve the use of anti-depressant medication combined with face-to-face therapy for use with severe chronic episodes of depression, anxiety or severe mental illness in combination with CBT and regular monitoring for suicidal ideation and behaviour (van Straten et al., 2010). As a first step intervention, the ‘watchful waiting’ approach has two limitations. First, as general practitioners (GPs) are often the first point of contact for people with mild mental health symptoms (Council of Australian Governments, 2006), the onus of watchful waiting would be placed upon GPs. Nonetheless, GPs are under pressure to treat many people within a day and to keep appointment times brief. In Australia, for example, the current average appointment time for GPs is approximately 15 minutes per patient (Britt, Valenti, & Miller, 2002). Second, GPs are more likely to identify mental health problems in young people who are aware of emotion distress (Haller, Sanci, Sawyer, & Patton, 2009); therefore, Sylvia Kauer University of Melbourne, Australia & Murdoch Children’s Research Institute, Australia
SnpHub: an easy-to-set-up web server framework for exploring large-scale genomic variation data in the post-genomic era with applications in wheat

Abstract Background The cost of high-throughput sequencing is rapidly decreasing, allowing researchers to investigate genomic variations across hundreds or even thousands of samples in the post-genomic era. The management and exploration of these large-scale genomic variation data require programming skills. The public genotype querying databases of many species are usually centralized and implemented independently, making them difficult to update with new data over time. Currently, there is a lack of a widely used framework for setting up user-friendly web servers to explore new genomic variation data in diverse species. Results Here, we present SnpHub, a Shiny/R-based server framework for retrieving, analysing, and visualizing large-scale genomic variation data that can be easily set up on any Linux server. After a pre-building process based on the provided VCF files and genome annotation files, the local server allows users to interactively access single-nucleotide polymorphisms and small insertions/deletions with annotation information by locus or gene and to define sample sets through a web page. Users can freely analyse and visualize genomic variations in heatmaps, phylogenetic trees, haplotype networks, or geographical maps. Sample-specific sequences can be accessed as replaced by detected sequence variations. Conclusions SnpHub can be applied to any species, and we build up a SnpHub portal website for wheat and its progenitors based on published data in recent studies. SnpHub and its tutorial are available at http://guoweilong.github. io/SnpHub/. The wheat-SnpHub-portal website can be accessed at http://wheat.cau. edu.cn/Wheat_SnpHub_Portal/.
A Milliwatt-Level 70–110 GHz Frequency Quadrupler With >30 dBc Harmonic Rejection

This article presents a two-channel 70–110-GHz frequency quadrupler in the GF8HP 0.12-<inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> SiGe BiCMOS process. The <inline-formula> <tex-math notation="LaTeX">$\times 4$ </tex-math></inline-formula> frequency multiplication is based on cascaded frequency doublers with an interstage bandpass filter to reject undesired harmonics. The measured peak output power is −1.5 to 3 dBm at 70–110 GHz, with a worst case harmonic rejection ratio (HRR) of >30 dBc. The chip size is 1.9 mm<sup>2</sup> and consumes 240 mW for the two-channel operation. To the best of our knowledge, this article represents state-of-the-art in terms of bandwidth, output power, and excellent HRR. Application areas include mm-wave multi-channel, mm-wave network analyzers, and wideband sources for radar and imaging systems and reconfigurable E-band radios.
The Evaluation of a Prothrombotic Risk in a Human Fibrinogen Concentrate

Fibrinogen is a circulating coagulant protein which is converted to polymerizable fibrin by thrombin. The human fibrinogen concentrate (FC) (CSL Behring) has been used for the treatment of bleeding in fibrinogen deficiency. In this investigation we investigated the prothrombotic potential of FC using the in-vivo, Wessler venous stasis assay in rabbits Thrombogenicity in clinical use was assessed in a postmarketing drug surveillance review. Forty-five rabbits were randomized to receive either placebo or 40 mg/kg of one of four different lots of FC, injected into a marginal ear vein. Thirty seconds thereafter, a segment of the right jugular vein (1.5 – 2.0 cm) was ligated. After 15 minutes the segment was removed and evaluated for thrombus formation according to a score system from 0 –3. Thrombogenic materials, such as activated prothrombin complexes, have consistently shown high scores of thrombus formation in this assay. The mean score in the FC treated rabbits (0.85 ± 1.04) was not different from that in the placebo-treated rabbits (0.8 ± 0.84). Postmarketing data was comprised of spontaneous reports to a postmarketing surveillance system for Adverse Drug Reports (ADR). The number of ADR reports was expressed relative to the number of estimated single standard doses. The estimated dose per patient was adjusted to the degree of bleeding (between one to eight gram). Between January 01, 1986 and April 30, 2008 in total 983,195 g of Haemocomplettan® P had been distributed. Very few reports (n=9) of thromboembolic events have been reported throughout postmarketing surveillance, corresponding to one case report for every 13,655 treatments of 8 grams FC. The reported thromboembolic events occurred in patients with congenital afibrinogenemia or acquired hypofibrinogenemia. In most cases, patients had additional risk factors (e.g. concomitant administration of blood products prothrombin complex concentrate, platelet concentrates, activated factor VII, etc.). Although a causal relationship to administration of FC could not be definitely excluded, the occurrence of thromboembolic events is very rare. From congruent results of both a classical preclinical model of thrombogenicity and analysis of postmarketing data, FC appears to have a very low risk of thrombogenicity.
Reading Strategies for Effective English Language Instruction

The objectives behind this strategy are as follows: it increases reading comprehension through collaborative learning and understanding of new words and main ideas in an interactive manner; promotes accountability in the classroom, as students need to be responsible about assigned tasks to reach a common goal; and improves listening, communication, problem-solving skills, and interpersonal skills. That is to say, the jigsaw reading strategy helps language students create learning in a meaningful way by being accountable of their own learning as well as by learning from their peers.
Prospects and perspectives of breeding science

1) Faculty of Agriculture, Kibi International University, Minami-Awaji, Hyogo 656-0484 2) Faculty of Agriculture, Kindai University, Nara, Nara 631-8505 3) Tohoku University, Sendai, Miyagi 980-8577 4) Institute of Crop Science, NARO, Tsukuba, Ibaraki 305-8518 5) Fukui Agricultural Experiment Station, Fukui, Fukui 918-8215 6) Plant Breeding & Experiment Station, Takii & Company, Limited, Konan, Shiga 520-3231 7) Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo 113-8657 8) Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido 060-8589
Moderating Earning Management: Quality of Internal Auditors, Business Strategy, and Sustainability Reporting on Economic Performance

This research aims to determine the effect of internal auditor quality, business strategy, and sustainability reporting on economic performance with moderated by earning management partially on companies kompas100 index during the period 2013-2016.The population in this research is all companies kompas100 index listed on Indonesia Stock Exchange during the period 2013-2016. The total samples tested were 9 companies selected by purposive sampling technique. Data type in this research use secondary data obtained from Indonesia Stock Exchange and site respectively of company being sampled. Data analysis technique use panel data regression with Eviews 9.0 program. The result indicates that internal auditor quality have a positive effect on economic performance but after moderated by earning management of internal auditor quality has no effect on economic performance. Business strategy have a positive effect on economic performance but after moderated by earning management of business strategy has a negative effect on economic performance. Sustainability reporting have no effect on economic performance but after moderated by earning management of sustainability reporting has no effect on economic performance and return on assets as control variable have a positive effect on economic performance. Keywords: Economic performance, Internal Auditor Quality, Business Strategy, Sustainability Reporting. DOI : 10.7176/RJFA/11-2-09 Publication date: January 31 st 2020
Phase III trial (NGR015) with NGR-hTNF plus best investigator choice (BIC) versus placebo plus BIC in previously treated patients with advanced malignant pleural mesothelioma (MPM).

7501 Background: Currently, there are no standard options for MPM patients who failed a pemetrexed-based chemotherapy (CT). NGR-hTNF, a tumor-targeted antivascular agent, displays antitumor activity through a vessel normalization that improves intratumor CT uptake and T-cell infiltration. Methods: MPM patients who progressed on or after a front-line pemetrexed-based regimen, stratified for performance status (PS) and CT agent, were randomly assigned to receive weekly NGR-hTNF 0.8 μg/m2 (arm A; n = 200) or placebo (arm B; n = 200), both given with BIC (gemcitabine [G], vinorelbine [V], doxorubicin [D] or supportive care). Primary endpoint was overall survival (OS). Hypothesis testing: hazard ratio (HR) = 0.72, 1-β = 0.80, α = 0.05. Results: Baseline characteristics were balanced between arms (A vs B): median age (65 vs 67 years); men (76% vs 74%); PS ≥ 1 (72% vs 69%); nonepithelial histology (15% vs 19%); poor EORTC score (30% vs 23%); prior treatment-free interval (TFI) < median of 4.8 months (47% vs 53%).
First-principles-based multiple-isotope particle transport modelling at JET

Core turbulent particle transport with multiple isotopes can display observable differences in behaviour between the electron and ion particle channels. Experimental observations at JET with mixed H-D plasmas and varying NBI and gas-puff sources (Maslov et al 2018 Nucl. Fusion 7 076022) inferred source dominated electron peaking, but transport dominated isotope peaking. In this work, we apply the QuaLiKiz quasilinear gyrokinetic transport model within JINTRAC flux-driven integrated modelling, for core transport validation in this multiple-isotope regime. The experiments are successfully reproduced, predicting self consistently j , ne, nBe, Te, Ti, and the isotope composition. As seen in the experiments, both H and D profiles are predicted to be peaked regardless of the core isotope source. An extensive sensitivity study confirmed that this result does not depend on the specific choices made for the boundary conditions and physics settings. While kinetic profiles and electron density peaking did vary depending on the simulation parameters, the isotope ratio remained nearly invariant, and tied to the electron density profile. These findings have positive ramifications for multiple-isotope fuelling, burn control, and helium ash removal.
Response Assessment of Bevacizumab for Treatment of Malignant Glioma by Neuroimaging

Since 2013, antiangiogenic therapy such as bevacizumab has been introduced in Japan for treatment of malignant gliomas, and previous studies have shown that a problem of pseudoresponse cannot be solved by evaluating images of the treatment. For rapidly reduced enhanced lesions after the initiation of bevacizumab, it would be mistaken to determine high response rate. The Response Assessment in Neuro‒Oncology(RANO)group recommends fluid‒attenuated inversion recovery(FLAIR)or T2 hyper‒intensity to determine tumor progression during the bevacizumab therapy. However, since tumor‒related edema, ischemia and radiation effects can all result in increased hyper‒intensity area on FLAIR and T2WI, it is difficult to evaluate the activity of tumor. To this end, hypovascularized diffusion‒weighted imaging(DWI), decreased relative cerebral blood volume(rCBV)on dynamic susceptibility contrast(DSC)perfusion weighted imaging(PWI)and increased ratio between N‒acetyl‒aspartate(NAA)and choline(Cho)on MR spectroscopy may represent imaging biomarkers for the improved outcome of the therapy. For assessment of treatment response to bevacizumab therapy, additional metabolic PET imaging provides an important and valuable addition to standard MRI. Amino acid PET tracers such as 11C‒methionine(MET), O‒ (2‒18F‒fluoroethyl)‒L‒tyrosine(FET)and L‒3,4‒dihydroxy‒6‒18F‒fluoro‒phenylalanine(FDOPA)have been evaluated for the assessment of treatment response to the therapy. Recent studies suggest that changes in FET and FDOPA PET parameters such as metabolically active tumor volume are useful for determining treatment failure at earlier time point than MRI‒based RANO criteria and have also been used to predict a favorable outcome for responders to bevacizumab. 18F‒fluoro‒3’‒deoxy‒3’‒L‒fluorothymidine(FLT)is a helpful predictor of glioma progression. However, the assessment of treatment response to the therapy based on FLT needs careful interpretation because FLT is significantly dependent on blood brain barrier permeability. 18F‒fluoromisonidazole(FMISO)could evaluate the dynamic biological effects between tissue hypoxia and vascular normalization occurring within recurrent high‒grade glioma treated by bevacizumab. These multiple imaging modalities combining standard MRI with new physiological MRI and metabolic PET imaging may have a capacity to detect the susceptibility to bevacizumab therapy and will increasingly become important biomarkers in the future. (Received January 29, 2016;accepted March 16, 2016)
Engaging the Paradoxical: Zeno's Paradoxes in Three Works of Interactive Fiction

For over two millennia thinkers have wrestled with Zeno’s paradoxes on space, time, motion, and the nature of infinity. In this article we compare and contrast representations of Zeno’s paradoxes in three works of interactive fiction, Beyond Zork, The Chinese Room, and A Beauty Cold and Austere. Each of these works incorporates one of Zeno’s paradoxes as part of a puzzle that the player must solve in order to advance and ultimately completely the story. As such, the reader must engage more deeply with the paradoxes than he or she would in a static work of fiction. In addition, each of the three works presents a different perspective on the intellectual challenges associated with the paradoxes.
BRICS-T ÜLKELERİNDE EKONOMİK BÜYÜME VE KÜRESELLEŞME İLİŞKİSİ*

Dunya ekonomik sistemi uzerinde ciddi etkisi olan kuresellesmenin ulkeler uzerinde etkisinin farkli oldugu gorulmektedir. Kuresellesme ile ulkeler arasinda olusan yogun ekonomik, sosyal ve politik iliskiler ulkelerin ekonomik buyume performansi uzerinde de olumlu ya da olumsuz etkiler ortaya cikarmaktadir. Bu calismada kuresellesmenin ekonomik buyume uzerindeki etkisinin BRICS-T ulkeleri icin incelenmesi amaclanmaktadir. Bu dogrultuda, kuresellesmenin reel GSYH uzerindeki etkisi, 1990-2014 donemi icin Pedroni ve Kao esbutunlesme testi ve FMOLS katsayi tahmincisi araciligiyla incelenmistir. Degiskenler arasindaki nedensellik iliskisi ise Dumitrescu ve Hurlin (2012) Panel Granger Nedensellik Testi ile arastirilmistir. Ayrica, ampirik modelin Cobb-Douglas uretim fonksiyonuna dayali olarak kurulmasi nedeniyle sermaye degiskeni de modele bagimsiz degisken olarak dahil edilmistir. Calismada elde edilen bulgular sonucunda kuresellesmenin ve sermayenin birikiminin milli gelir uzerinde etkisinin pozitif oldugu gorulmustur. Degiskenler arasindaki nedensellik iliskisi incelendiginde kisi basina dusen sermaye birikimi ve ekonomik buyume arasinda cift yonlu, kuresellesmeden ekonomik buyumeye dogru tek yonlu, kisi basina dusen sermaye birikiminden kuresellesmeye dogru tek yonlu nedensellik iliskisi oldugu gorulmustur. Bu dogrultuda ulkelerin kuresellesme seviyelerinin yukseltilmesinin ulkelerin ekonomik buyumelerinde avantaj saglayacagi degerlendirilmektedir.
Data-driven Business Models in Logistics: A Taxonomy of Optimization and Visibility Services

The nature of business conduct is changing due to emerging digital technologies and the ever-increasing role of data as a critical resource. Traditional industry branches such as logistics need to adapt accordingly to keep up with change through digitization and to design adequate business models using data. The present article focuses on investigating the anatomy of these data-driven business models in the logistics sector. In order to achieve this goal, the study develops a taxonomy of data-driven business models in logistics. Start-ups serve as the frame of reference, as they are particularly suitable for deriving explicitly novel and vital business models. The study focuses on two particular types of data-driven business models, namely those offering visibility or optimization services in logistics. The goal of the taxonomy is to uncover the structural composition of such business models and to make the results usable as a morphology for innovation.
Má měnový agregát M3 vliv na inflaci? Případová studie České republiky, Švýcarska a Izraele

The aim of the paper is to analyse the influence of monetary aggregate M3 on inflation in the Czech Republic, Switzerland and Israel between the years 2000 and 2017. The central banks in selected countries have not been able to fulfill their stated goal of achieving price stability. During the period under review, the selected central banks chose foreign exchange intervention as an instrument of unconventional monetary policy to achieve the set inflation target. The analysis of monetary policy in the selected countries will be determined by the long-term relationships between the M3 monetary aggregate and the inflation. Selected indicators were analyzed on quarterly data in the Czech Republic, Switzerland and Israel using the Engle Granger cointegration test. We have found, based on the tests performed, that monetary policy in the monitored countries was not quite effective in the years 20002017 because we did not confirm in our empirical analyzes the long-term relationship between the monetary aggregate M3 in relation to inflation.
PERSIST: A programmable RNA regulation platform using CRISPR endoRNases

Regulation of transgene expression is becoming an integral component of gene therapies, cell therapies and biomanufacturing. However, transcription factor-based regulation upon which the majority of such applications are based suffers from complications such as epigenetic silencing, which limits the longevity and reliability of these efforts. Genetically engineered mammalian cells used for cell therapies and biomanufacturing as well as newer RNA-based gene therapies would benefit from post-transcriptional methods of gene regulation, but few such platforms exist that enable sophisticated programming of cell behavior. Here we engineer the 5’ and 3’ untranslated regions of transcripts to enable robust and composable RNA-level regulation through transcript cleavage and, in particular, create modular RNA-level OFF- and ON-switch motifs. We show that genomically introduced transgenes exhibit resistance to silencing when regulated using this platform compared to those that are transcriptionally-regulated. We adapt nine CRISPR-specific endoRNases as RNA-level “activators” and “repressors” and show that these can be easily layered and composed to reconstruct genetic programming topologies previously achieved with transcription factor-based regulation including cascades, all 16 two-input Boolean logic functions, positive feedback, a feed-forward loop and a putative bistable toggle switch. The orthogonal, modular and composable nature of this platform as well as the ease with which robust and predictable gene circuits are constructed holds promise for their application in gene and cell therapies.
Determinants of net interest margin: the effect of capital requirements and deposit insurance scheme

ABSTRACT This paper analyzes the determinants of net interest margin with a focus on the impact of capital regulation and deposit insurance. We extend the Ho and Saunders (1981) family of models to explicitly include both capital requirement and the deposit insurance premium as determinants of net interest margin. The model predicts that the higher the capital requirements and deposit insurance premium, the higher banks’ interest rates will be. We test the theoretical model using panel data for OECD countries between 2000 and 2014. Our results support the positive relationship between both the capital requirement and the deposit insurance premium on interest margins. The most important determinants of the net interest margin are implicit payments, efficiency, average operating costs, the intensity of competition, the deposit insurance premium and capital stringency.