Miracle-dz/UniFAR-FTUs huggingface dataset:
Dendrite-Free Li Metal Plating/Stripping Onto Three-Dimensional Vertical-Graphene@Carbon-Cloth Host

Lithium metal is deemed as an ideal anode material for next-generation lithium ion batteries (LIBs) due to its high specific capacity and low redox potential. However, uncontrolled lithium dendrite formation during electrochemical deposition leads to a low Coulombic efficiency and serious safety issues, dragging metallic lithium anodes out of practical application. One promising strategy to suppress lithium dendrite issues is employing a three-dimensional host with admirable conductivity and large surface area. Herein, a vertical graphene nanosheet grown on carbon cloth (VG/CC) synthesized is adopted as the Li deposition host. The three-dimensional VG/CC with a large surface area can provide abundant active nucleation sites and effectively reduce the current density, leading to homogeneous Li deposition to overcome the dendrite issue. The Li@VG/CC anode exhibits a dendrite-free morphology after a long cycle and superior electrochemical performance to that of planar Cu current collector. It delivers a small voltage hysteresis of 90.9 mV at a high current density of 10 mA cm−2 and a Coulombic efficiency of 99% over 100 cycles at 2 mA cm−2. Our results indicate that this all-carbon-based nanostructure host has great potential for next-generation Li metal batteries.
Single-Trial Mechanisms Underlying Changes in Averaged P300 ERP Amplitude and Latency in Military Service Members After Combat Deployment

Attenuation in P300 amplitude has been characterized in a wide range of neurological and psychiatric disorders such as dementia, schizophrenia, and posttraumatic stress disorder (PTSD). However, it is unclear whether the attenuation observed in the averaged event-related potential (ERP) is due to the reduction of neural resources available for cognitive processing, the decreased consistency of cognitive resource allocation, or the increased instability of cognitive processing speed. In this study, we investigated this problem by estimating single-trial P300 amplitude and latency using a modified Woody filter and examined the relation between amplitudes and latencies from the single-trial level to the averaged ERP level. ERPs were recorded from 30 military service members returning from combat deployment at two time points separated by 6 or 12 months. A conventional visual oddball task was used to elicit P300. We observed that the extent of changes in the within-subject average P300 amplitude over time was significantly correlated with the amount of change in three single-trial measures: (1) the latency variance of the single-trial P300 (r = −0.440, p = 0.0102); (2) the percentage of P300-absent trials (r = −0.488, p = 0.005); and (3) the consistent variation of the single-trial amplitude (r = 0.571, p = 0.0022). These findings suggest that there are multiple underlying mechanisms on the single-trial level that contribute to the changes in amplitudes seen at the averaged ERP level. The changes between the first and second assessments were quantified with the intraclass correlation coefficient, the standard error of measurement and the minimal detectable difference. The unique population, the small sample size and the large fraction of participants lost to follow up precludes generalizations of these measures of change to other populations.
Improving Scratch Programming with CRC-Card Design

Scratch and other block-based programming environments are popular and successful in engaging young learners with basic concepts of programming. It is common, and intentional, that programming with Scratch is done using an explorative "tinkering" approach, where blocks are selected from toolboxes and assembled. However, this type of bottom-up programming behaviour is generally associated with code quality issues, makes it difficult to create more complex programs, and may impede the learning of fundamental concepts. In order to investigate whether a more structured approach is feasible, we adapted the object-oriented design methodology of CRC cards (class-responsibility-collaboration) to Scratch programs, such that learners first plan the central aspects of their programs (i.e., the sprites and their interactions), before writing the code. We applied this methodology in the context of a pilot study with two school classes to investigate how this affects the students and their resulting projects. The results of this initial investigation suggest that students are not deterred by the additional design work, and we observed a slight improvement in the completeness and correctness of the resulting programs.
The Effectiveness of a Program of Physical Activity and Diet to Modify Cardiovascular Risk Factors in Patients with Severe Mental Illness (CAPiCOR Study)

Background: Patients with severe mental disorders have a higher prevalence of cardiovascular risk factors. Obesity and sedentarism are cardiovascular risk factors and their control reduces morbidity and mortality. Thus, interventions directed toward decreasing weight and/ or increasing the level of physical activity are necessary. Objectives: The aim of this study would be to evaluate the effectiveness of an educational intervention focused on diet and physical activity in order to change the amount of physical activity, Body Mass Index and waist circumference in these patients. Design: Randomized clinical trial with a control group with one-year follow-up. Setting: Outpatient Mental Health Teams of Barcelona and a residence for patients with severe mental disorders. Participants: Patients between 18 and 65 years of age diagnosed with schizophrenia, a schizoaffective disorder or bipolar disorder in treatment with antipsychotic medication and a low level of physical activity (240 patients in each randomized group). Intervention group: Physical activity group educational program of 24 sessions over 12 weeks and diet (16 sessions in the fist 8 weeks) carried out by nurses and physical activity specialists. Control group: Usual practice with regular checks and the usual t reatment of their disease. Main outcome measures: Level of physical activity (IPAQ questionnaire), weight, Body Mass Index and waist circumference. Other outcomes: Cardiovascular risk, quality of life (SF-36 questionnaire), tobacco consumption, dietary habit (PREDIMED questionnaire), blood pressure and laboratory parameters (cholesterol, triglycerides, glucose). Evaluations will be masked and will be made at 0, 3, 6 and 12 months. Data analysis: Intention to treat analysis. Analysis of variance for repeated measures to adjust for differences attributable to the effect o f the intervention for potential confounders (drug treatment, care level of intervention and mental status of the patient). Ethical aspects: The project has been evaluated and approved by the ethics committee (CEIC) of the Primary Healthcare-University Research Institute IDIAP Jordi Gol, with registration number P11/64. Trial registration: Clinicaltrials.gov NCT01729650.
Reversal of Anticoagulants in Critical Care

ABSTRACT There has seen an increase in anticoagulant consumption worldwide over the past few decades. With this widespread utilization of anticoagulants, clinicians are increasingly likely to encounter situations where anticoagulants would need to be withheld. This includes emergency and elective procedures or surgeries as well as major or minor bleeding as a direct result of over anticoagulation or consequent to other intercurrent illnesses such as sepsis or trauma with multiorgan failure, where the anticoagulant may contribute to coagulation abnormalities. Clinicians are required to have a thorough understanding of the indications for anticoagulant prescription, drug interactions and monitoring, indications and options of reversal of anticoagulation and management of bleeding in the situations described above. Once the acute process is managed, the ongoing need and timing of reinitiation of anticoagulation is also crucial. This article provides an overview on the indications for reversal of anticoagulation, the agents used for reversal and the timing of reinitiation of anticoagulants. How to cite this article Chacko B, Peter JV, Subramani K. Reversal of Anticoagulants in Critical Care. Indian J Crit Care Med 2019;23(Suppl 3):S221–S225.
Aspergillus terreus obtained from mangrove exhibits antagonistic activities against Pythium aphanidermatum-induced damping-off of cucumber

A study was conducted to investigate the potential of Aspergillus terreus obtained from Avicennia marina mangrove roots in inhibiting Pythium aphanidermatum and damping-off disease of cucumber. Aspergillus terreus exhibited in vitro inhibition of Pythium aphanidermatum growth. Electron microscope examination revealed that the antagonistic fungal isolate resulted in shrinking and groves in Pythium hypha. When Aspergillus terreus culture filtrate was added to Pythium aphanidermatum, it resulted in a significant increase (by 73%) in electrolyte leakage from Pythium hypha compared to the control, as well as significant reduction (by 71%) in oospore production. The Aspergillus terreus culture was also found to produce a cellulase enzyme, which is suggested to be involved in the antagonism against Pythium aphanidermatum. Adding Aspergillus terreus to soil infested with Pythium aphanidermatum significantly reduced percent mortality in cucumber seedlings by 70%. Aspergillus terreus, when applied alone on cucumber seedlings, did not show any suppressive effects on cucumber growth (length and fresh and dry weight). This appears to be the first report of isolation from mangrove of Aspergillus terreus with antagonistic activity against Pythium aphanidermatum-induced damping-off of cucumber. The study indicates that fungal isolates obtained from marine environments may serve as potential biocontrol agents against some plant pathogens.
Synthesis, Pharmacological and Toxicological Screening of Penicillin–Triazole Conjugates (PNTCs)

A series of hybrid antimicrobial compounds were prepared by carboxylic acid protection of 6-aminopenicillanic acid using benzyl alcohol and thionyl chloride succeeded by azide displacement using trifluoromethanesulfonyl azide in dichloromethane. The azide thus formed was reacted with substituted alkynes to furnish benzyl-protected penicillin–triazole conjugates. Benzyl deprotection of the conjugates resulted in furnishing PNTCs under water methanol mixture using Pd/C as a catalyst. The PNTCs (7a–j) formed were screened for in vitro antibacterial potency against pathogenic strains of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pyogenes and antifungal potency against Candida albicans, Aspergillus niger, and Aspergillus clavatus. Further antimicrobial evaluation revealed compounds 7c, 7d, 7e, 7g, and 7i to be the most compounds of the series with minimum inhibitory concentration value for antibacterial in the range 0.5–50 μg/mL and for antifungal in the range 9–300 μg/mL. Toxicological analysis documented for compounds 7c, 7d, 7e, 7g, and 7i revealed compound 7i to be the most promising member of the series with 1000 and 500 mg/kg LD50, and no-observed-adverse-effect level to facilitate future clinical studies of the same.
Dissecting racial bias in an algorithm used to manage the health of populations

Racial bias in health algorithms The U.S. health care system uses commercial algorithms to guide health decisions. Obermeyer et al. find evidence of racial bias in one widely used algorithm, such that Black patients assigned the same level of risk by the algorithm are sicker than White patients (see the Perspective by Benjamin). The authors estimated that this racial bias reduces the number of Black patients identified for extra care by more than half. Bias occurs because the algorithm uses health costs as a proxy for health needs. Less money is spent on Black patients who have the same level of need, and the algorithm thus falsely concludes that Black patients are healthier than equally sick White patients. Reformulating the algorithm so that it no longer uses costs as a proxy for needs eliminates the racial bias in predicting who needs extra care. Science, this issue p. 447; see also p. 421 A health algorithm that uses health costs as a proxy for health needs leads to racial bias against Black patients. Health systems rely on commercial prediction algorithms to identify and help patients with complex health needs. We show that a widely used algorithm, typical of this industry-wide approach and affecting millions of patients, exhibits significant racial bias: At a given risk score, Black patients are considerably sicker than White patients, as evidenced by signs of uncontrolled illnesses. Remedying this disparity would increase the percentage of Black patients receiving additional help from 17.7 to 46.5%. The bias arises because the algorithm predicts health care costs rather than illness, but unequal access to care means that we spend less money caring for Black patients than for White patients. Thus, despite health care cost appearing to be an effective proxy for health by some measures of predictive accuracy, large racial biases arise. We suggest that the choice of convenient, seemingly effective proxies for ground truth can be an important source of algorithmic bias in many contexts.
Minimal navigation solution for a swarm of tiny flying robots to explore an unknown environment

A minimal navigation solution is presented for swarms of tiny flying robots to explore unknown, GPS-denied environments. Swarms of tiny flying robots hold great potential for exploring unknown, indoor environments. Their small size allows them to move in narrow spaces, and their light weight makes them safe for operating around humans. Until now, this task has been out of reach due to the lack of adequate navigation strategies. The absence of external infrastructure implies that any positioning attempts must be performed by the robots themselves. State-of-the-art solutions, such as simultaneous localization and mapping, are still too resource demanding. This article presents the swarm gradient bug algorithm (SGBA), a minimal navigation solution that allows a swarm of tiny flying robots to autonomously explore an unknown environment and subsequently come back to the departure point. SGBA maximizes coverage by having robots travel in different directions away from the departure point. The robots navigate the environment and deal with static obstacles on the fly by means of visual odometry and wall-following behaviors. Moreover, they communicate with each other to avoid collisions and maximize search efficiency. To come back to the departure point, the robots perform a gradient search toward a home beacon. We studied the collective aspects of SGBA, demonstrating that it allows a group of 33-g commercial off-the-shelf quadrotors to successfully explore a real-world environment. The application potential is illustrated by a proof-of-concept search-and-rescue mission in which the robots captured images to find “victims” in an office environment. The developed algorithms generalize to other robot types and lay the basis for tackling other similarly complex missions with robot swarms in the future.
Dental caries and salivary Interleukin-6 among preterm postpartum women in relation to baby birth weight (Comparative study)

The physiologic, biochemical and anatomic changes that occur during pregnancy are extensive and may be systemic or local. However, most of these changes return to pre pregnancy status six weeks postpartum. The aim of the study was to investigate the effect of dental caries among preterm postpartum women and it's relation to baby birth weight and salivary interleukin-6 (IL-6). Materials and methods: 66 postpartum women were examined, 33 preterm postpartum women (study group) and 33 full term postpartum women (control group). Dental caries was recorded using, decayed, missing and filled surfaces index, also assess the decayed lesion by severity. Salivary samples were taken from all subjects to estimate salivary IL- 6 levels. Babies' birth weight also was measured. Results: Data of the present study showed a higher caries severity among study group compared to control group, with no statistically significant difference (P> 0.05). For both groups, the initial decayed surface D 2 was the lightest value for both groups. While the deep frank cavitations D 4 was the lowest in study group with no data recording among control group. The result revealed highly significant difference in baby birth weight between the two groups. The correlation between DS and salivary IL-6 was highly significant, and a significant correlation noticed between D3 and salivary IL-6 in study group. In control group, a highly significant positive correlation was detected between baby birth weight and DMFS, and a significant correlation was obscured between baby birth weight with decayed surface, also a significant correlation was found between salivary IL-6 and decayed surface in the same group. Conclusion: During pregnancy, a woman may be particularly amenable to disease prevention and health promotion interventions that could enhance her oral health on that of her infant's, due to the potential associations between oral health and preterm delivery and baby birth weight. Keywords; Dental caries, salivary IL-6, preterm postpartum women, baby birth weight. (J Bagh Coll Dentistry 2013;
The effects of medication adherence on study outcomes in randomized clinical trials: A role for cognitive dysfunction?

Abstract Medication nonadherence is common and has been associated with poor health outcomes. Older adults are especially likely to be non-adherent to their medications, as they often have more medications to manage and are at greater risk for cognitive dysfunction. Though less frequently examined, the association between cognitive dysfunction and nonadherence also likely extends to clinical trials research. The current study used archival data to examine the potential impact of cognitive dysfunction on adherence to a nutritional supplement as part of a 90-day randomized clinical trial in neurologically healthy middle-aged and older adults. Results showed overall cognitive performance was predictive of adherence to capsule intake when controlling for polypharmacy [F(1,157) = 6.53, p < . 01]. These results suggest that cognitive dysfunction may impact findings from RCTs through its adverse impact on adherence to study protocol, possibly leading to greater treatment variance, artificially reduced treatment effects, lower study power, and distorted study outcomes and conclusions. A better understanding of methodological and statistical approaches to account for these unwanted effects are needed.
New Insights into Malaria Pathogenesis.

Malaria remains a major public health threat in tropical and subtropical regions across the world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 deaths per year, predominantly in young children in sub-Saharan Africa. Therefore, it is imperative to understand why a subset of infected individuals develop severe syndromes and some of them die and what differentiates these cases from the majority that recovers. Here, we discuss progress made during the past decade in our understanding of malaria pathogenesis, focusing on the major human parasite Plasmodium falciparum. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease, Volume 15 is January 24, 2020. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Trombolisis acelerada en tromboembolismo pulmonar agudo con seguimiento ecocardiográfico y tomográfico.

El tromboembolismo pulmonar es una enfermedad frecuente y muchas veces fatal. En un estudio en los EE.UU de 42 millones de muertes por un periodo de 20 anos, alrededor de 600.000 pacientes (1,5%) fueron diagnosticados con embolismo pulmonar. Sin embargo, este estudio seguramente infraestima la verdadera prevalencia e incidencia de esta entidad, debido a que mas de la mitad de estos casos no son diagnosticados. Se presenta una paciente femenina, mestiza de 46 anos de edad con APP de Hipotiroidismo e Hipertension Arterial no tratados y Tendosinovitis en miembro inferior derecho que la mantuvo con un mes de estadia en cama, con 10 dias de terapia de rehabilitacion cardiaca, manteniendo aun importante limitacion funcional.
Variabilidad genética de poblaciones de Triatoma flavida (Hemiptera: Reduviidae) en la península de Guanahacabibes

INTRODUCTION: chagas disease is a Triatomineos-borne disease. Triatoma flavida is an indigenous Cuban species, presumably attracted to houses by light and it is the most abundant species in the country. OBJECTIVE: the intrapopulatinal and interpopulational genetic variability of T. flavida collected in the western region, using the Random Amplified Polymorphic DNA (RAPD) technique, thus determining possible genetic relationships among the populations. METHODS: a total of ten random primers (OPA-1 at the 10) were used to evaluate the genetic variability in one population and among 9 populations of T. flavida using the RAPD technique. We also evaluate the genetic diversity among wild individuals and their first generation (F1) obtained in the laboratory as well as different stages of this species. RESULTS: differences were not detected in the amplification patterns among the wild individuals and the F1. The same results were achieved among different life cycles of this species. Genetic homogeneity of the studied population and low genetic variability among different T. flavida populations were observed. Two well-defined groups were obtained according to random amplified polymorphic DNA data; they matched with the geographical origin in the populations captured in areas from east and west of Guanahacabibes, Pinar del Río. Among these populations, small genetic differentiation (Fst 0,030) was found as well as migration rates (N> 1), which reveals the gene flow and genetic homogeneity. CONCLUSIONS: The results of this study constitute an approach to the genetic structure of T. flavida. The genetic homogeneity between wild individuals of T. flavida represents an important item for the implementation of the vector control
Association of Body Mass Index and Extreme Obesity With Long‐Term Outcomes Following Percutaneous Coronary Intervention

Background Previous studies have reported a protective effect of obesity compared with normal body mass index (BMI) in patients undergoing percutaneous coronary intervention (PCI). However, it is unclear whether this effect extends to the extremely obese. In this large multicenter registry‐based study, we sought to examine the relationship between BMI and long‐term clinical outcomes following PCI, and in particular to evaluate the association between extreme obesity and long‐term survival after PCI. Methods and Results This cohort study included 25 413 patients who underwent PCI between January 1, 2005 and June 30, 2017, who were prospectively enrolled in the Melbourne Interventional Group registry. Patients were stratified by World Health Organization–defined BMI categories. The primary end point was National Death Index–linked mortality. The median length of follow‐up was 4.4 years (interquartile range 2.0‐7.6 years). Of the study cohort, 24.8% had normal BMI (18.5‐24.9 kg/m2), and 3.3% were extremely obese (BMI ≥40 kg/m2). Patients with greater degrees of obesity were younger and included a higher proportion of diabetics (P<0.001). After adjustment for age and comorbidities, a J‐shaped association was observed between different BMI categories and adjusted hazard ratio (HR) for long‐term mortality (normal BMI, HR 1.00 [ref]; overweight, HR 0.85, 95% CI 0.78‐0.93, P<0.001; mild obesity, HR 0.85, 95% CI 0.76‐0.94, P=0.002; moderate obesity, HR 0.95, 95% CI 0.80‐1.12, P=0.54; extreme obesity HR 1.33, 95% CI 1.07‐1.65, P=0.01). Conclusions An obesity paradox is still apparent in contemporary practice, with elevated BMI up to 35 kg/m2 associated with reduced long‐term mortality after PCI. However, this protective effect appears not to extend to patients with extreme obesity.