Miracle-dz/UniFAR-FTUs huggingface dataset:
The Power of Social Media in the Promotion and Tenure of Clinician Educators

Introduction Social networking sites (or social media [SM]) are powerful web-based technologies used to bolster communication. SM have changed not only how information is communicated but also the dissemination and reception of a variety of topics. This workshop highlighted the benefits of SM for clinician educators. The use of SM was explored as a way to maximize opportunities for clinician educators to network, establish themselves as experts, and build a national reputation leading to promotion. The target audience for this submission is faculty developers who would like to implement a similar workshop, and clinician-educator faculty motivated by promotion and advancement. Methods The training workshop involved an interactive session, with approximately 20 minutes of content, 20 minutes of individual and small-group activities, and 15 minutes of large-group discussion. The effectiveness of the workshop was evaluated by asking participants to complete a postsession survey of SM knowledge, attitude, and action. Results Survey responses (n = 14) demonstrated an increase in participants’ knowledge of SM platforms, ability to identify benefits of SM, skills to disseminate their work, and eagerness to build their personal brand. Discussion This workshop provided a foundation for clinician educators to think strategically about SM use in ways that highlight access to a broader network of colleagues and potential collaborators and that influence the impact of publications and work.
Atypical Palmar Involvement with Erythema Elevatum Diutinum as a Sole Manifestation: A Report of Two Cases

Abstract Erythema elevated diutinum (EED) is a rare distinctive form of cutaneous leukocytoclastic vasculitis. EED typically presents with asymptomatic symmetrical erythematous-brown papules, nodules or plaques which favor the extensor aspect of extremities while distinctly sparing the palms. We report two cases of EED with a rare presentation limited to the palms.
Brain Temperature Fluctuations in Helmeted Guineafowl under Semi-Natural Conditions

Birds are generally assumed to regulate their brain temperature (Tbr) at a level somewhat lower than cloacal temperature (T1e) (Richards 1970, Kilgore et al. 1973, 1976). Some birds when heat-stressed elevate Tbr and TC1, such that TclTbr is relatively constant (Kilgore et al. 1973, 1976) whereas heat-stressed chickens do not have a Tcl-Tbr gradient (Richards 1970). We previously demonstrated that Helmeted Guineafowl (Numida meleagris) have a labile Tbr in the laboratory at ambient temperatures of 5-400C, whereas T~1 is constant (Crowe 1978, Crowe and Withers 1979; Fig. 1). We suggested that the naked head and neck of guineafowl might facilitate heat exchange with the environment, based upon laboratory data and other morphological evidence (Crowe 1978). However, we wished to document the normal pattern of Tbr, and determine if there was any physiological significance of the naked head and neck, under natural conditions. Furthermore, we are unaware of any data pertaining to brain temperature of free-ranging birds under natural or semi-natural conditions. We report here our findings from a telemetric study of guineafowl brain temperature under semi-natural conditions.
Endocrine Therapy Plus Anti-HER2 Therapy as Adjuvant Systemic Therapy for Luminal HER2-Positive Breast Cancer: An Analysis of the National Cancer Database

Background: Guidelines regarding the usage of adjuvant systemic therapy in patients with small human epidermal growth factor receptor 2 (HER2)-positive and estrogen receptor/progesterone receptor–positive (luminal HER2 positive) tumors are nonspecific. Outcomes of chemotherapy followed by endocrine therapy (ET), with or without anti-HER2 therapy, vs ET alone (no chemotherapy) have not been widely studied in this disease subtype. We sought to examine the usage and outcomes of adjuvant systemic therapy (ET vs chemotherapy with or without trastuzumab) in stage I luminal HER2-positive breast cancer (BC), based on the large National Cancer Database. Methods: We conducted a retrospective analysis of patients with luminal HER2-positive stage I BC, diagnosed between 2010 and 2015, in the United States, using univariable and multivariable logistic regression analyses. The Kaplan-Meier method estimated overall survival (OS). Results: A total of 37 777 patients were included in the analysis; of these, n = 32 594 (86%) received adjuvant ET and n = 5183 (14%) received chemotherapy. Around 40% of all patients received anti-HER2 therapy (trastuzumab). Patients who received trastuzumab had a better 5-year OS (93.4% vs 92.0%, P = .0002) compared with those who did not. Patients who received anti-HER2 therapy plus ET had the best OS rate at 5 years (93.5%, confidence interval [CI]: 89.2%-98%, P < .0001) compared with those receiving anti-HER2 therapy plus chemotherapy (92.7%, CI: 89.4%-96.1%, P < .0001). Conclusions: Most patients in the United States, with stage I luminal HER2 positive BC, received ET, not chemotherapy but most of them do not receive anti-HER2 therapy resulting in inferior outcome. Future trials exploring the de-escalation of systemic adjuvant therapy for early-stage luminal HER2-positive BC to ET plus anti-HER2 therapy would be desirable.
Teaching how to cite scientific articles: a study of citation deviation in citing "multi-authored papers" by top authors from Iranian Universities of Medical Sciences in 2017

Aim: The present study aims at teaching the right citation models in scientific publications by top authors from Iranian universities of medical sciences in 2017, considering the relationship between moral development and self-control variables and model of "citation to multi-authored papers" in these articles. Background: Multi-authorship increases the amount of self-citation and also increases the likelihood of being cited by others. Methods: This study is of the applied scientometrics and correlation (model presentation) studies type. The research population in the first part of this study includes all the authors who had an H-index of 10 or more in the scientific databases of 2017. The sample size at this stage was 110, selected by systematic random sampling. The collected data were analyzed using SPSS 16.0. Results: The results of regression analysis based on the concurrent method indicated that the regression model is significant. The coefficient of determination is 0.096 and the F ratio is 5.650, which are significant at the level of p <0.001. In this regression model, the variables of the level of moral development (β = -5.801, p <0.001) and self-control (p < 0.001, β = -0.253) have significant predictive power and can be considered as predictors of behavioral modeling in citing "multi-authored papers". Conclusion: Based on the results, teaching how to avoid blindly citing the "multi-authored papers", which is regarded as a kind of "citation deviation", can, to some extent, lead to strengthening citation indexes.
The Effects of a Recollection-Based Occupational Therapy Program of Alzheimer's Disease: A Randomized Controlled Trial

Considering the high socioeconomic costs related to the increasing number of dementia patients and their poor quality of life and that of their families, it is important to identify the condition early on and provide an appropriate intervention. This study organized a recollection-based occupational therapy program: a nonpharmacological intervention consisting of five categories of activities (physical, horticultural, musical, art, and instrumental activity of daily living; IADL) and applied it to those having a mild stage of Alzheimer's disease. The experimental group participated in a total of 24 sessions––five times per week for one hour per session––while the control group took part in regular activities offered by the existing facilities. The experimental group presented improved cognitive functions, reduced depression, and enhanced quality of life; the two groups showed a statistically significant difference in every category. This study is meaningful in that it made a cognitive stimulation program concerning five different categories, implemented it for people suffering mild dementia, and confirmed positive outcomes. If a systemic version of the program is offered in dementia care facilities, it is expected to make a considerable contribution to the care of dementia patients.
Protective Effects of Leukadherin1 in a Rat Model of Targeted Experimental Autoimmune Encephalomyelitis (EAE): Possible Role of P47phox and MDA Downregulation

Background Reactive oxygen and nitrogen species (ROS and RNS) are involved in pathologic mechanisms underlying demyelination and exacerbation in multiple sclerosis (MS) lesions. P47phox is the most important subunit of an ROS-producing enzyme (NADPH oxidase) which is reportedly upregulated in MS plaques due to the intense activity of infiltrated immune cells and resident microglia. Leukadherin1 is a specific CD11b/CD18 agonist that inhibits signaling and transmigration of inflammatory cells to sites of injury. Based on this mechanism, we evaluated therapeutic effects of leukadherin1 in an animal model of targeted experimental autoimmune encephalomyelitis (EAE) through focal injection of inflammatory cytokines to the spinal cord. Methods For model induction, Lewis rats were first immunized with 15µg MOG 1–125 emulsion. Twenty days later, animals were subjected to stereotaxic injection of IFNγ and TNFα to the specific spinal area (T8). One day after injection, all animals presented EAE clinical signs, and their behaviors were monitored for eight days through open-field locomotion and grid-walking tests. Leukadherin1-treated animals received daily intraperitoneal injections of 1mg/kg of the drug. The specific spinal tissues were extracted on day 5 in order to measure nitric oxide (NO), malon di-aldehyde (MDA), and TNFα concentrations alongside P47phox real-time PCR analysis. In addition, spinal sections were prepared for immunohistochemical (IHC) observation of infiltrated leukocytes and activated microglia. Results Leukadherin1 exhibited promising improvements in EAE clinical scores and behavioral tests. Demyelination, CD45+ leukocyte infiltration, and Iba1+ microglia activation were reduced in spinal tissues of leukadherin1-treated animals. Furthermore, P47phox expression levels, MDA, and NO amounts were decreased in treated animals. However, TNFα concentrations did not differ following treatment. Conclusion Based on our results, we suggest that leukadherin1 may be used as a novel therapeutic agent in tackling the clinical challenge of multiple sclerosis, especially during the acute phase of the disease. This effect was possibly mediated through decreased leukocyte infiltration and oxidative stress.
Floristic composition of a stand of Pinus oocarpa in Honduras

The species composition of a frequently burned, 1.7 ha stand of Pinus oocarpa Schiede in west-central Honduras is described. One hundred and twenty-four species of vascular plants were recorded, mostly perennial herbs, among which grasses, legumes, and composites were well represented. Variation was recorded in the frequency, density, and biomass of species growing in two sites within the stand. One site was burned during the dry season preceding the study, and the other was burned a year earlier. Forty-three percent of the genera also occurred in a previously studied pineland in Florida, and other comparisons with the Florida stand are noted. PINE FORESTS are common in Central America and extend as far south as Nicaragua (Critchfield and Little 1966). In neighboring Honduras 24 percent of the country is covered with pinelands (FAO Report 1968). The most common Honduran species is Pinus oocarpa Schiede, which grows between 600 and 1700 m above sea level and often forms pure stands (Molina 1964). The focus of this paper is the quantitative description of one such pure stand of Pinus oocarpa in west-central Honduras (fig. 1). This pineland was studied briefly in May 1972, at the end of the dry season by a class in Central American pineland ecology, sponsored by the Organization for Tropical Studies. The present investigation extended throughout the following wet or grow-
Cost of Hemodialysis Treatment and Associated Factors Among End-Stage Renal Disease Patients at the Tertiary Hospitals of Addis Ababa City and Amhara Region, Ethiopia

Purpose Hemodialysis is a renal replacement therapy for end-stage renal disease (ESRD) patients who consume substantial healthcare resources, which increases the economic burden. Plenty of factors affects the cost of hemodialysis treatment, particularly in resource-limited settings. Moreover, the demand for hemodialysis may decrease as the cost increases, but there is limited evidence in Ethiopia. Thus, this study aimed to estimate the cost of hemodialysis treatment among ESRD patients in the tertiary hospitals of Addis Ababa City and Amhara region, Ethiopia. Patients and Methods An institutional-based cross-sectional study was conducted among 172 ESRD patients undergoing hemodialysis treatment. A structured questionnaire and patients’ medical chart were used to estimate the costs, and the human capital approach was applied to calculate the indirect costs. A generalized linear model (GLM) was fitted after the modified park test to identify the associated factors. In the final GLM, a p-value of <0.05 and a 95% CI were used to declare the significant variables. Results The mean annual cost of hemodialysis treatment was 121,089.27ETB ($4466.59) ± 33,244.99 ($1226.29). The direct and indirect costs covered 77.0% and 23.0% of the total costs, respectively. Age (ex(b): 1.01, p-value <0.001), highest wealth status (ex(b): 1.09, p-value: 0.008), eight (ex(b): 1.27, p-value <0.001) and 12 visits/month (ex(b): 1.34, p-value <0.001), anemia (ex(b): 1.13, p-value <0.001), and comorbidity (ex(b): 1.09, p-value: 0.039) were the factors associated with the costs of hemodialysis treatment. Conclusion The annual cost of hemodialysis treatment among ESRD patients was high compared to the national per capita health expenditure, and two-thirds covered by the direct medical costs. Old age, high wealth status, more visits, anemia, and comorbidity were factors associated with the costs of hemodialysis. Therefore, the healthcare system must make a great effort for cost reduction and reduce the patients with kidney disease before they reach end-stages.
Avian Immune Responses: A Brief ReviewA

certain basic respects, most notably in the bird's possession of a bursa of Fabricius and the absence of organized lymph nodes. Nevertheless, there is no reason to suppose that birds differ significantly from mammals in the basic mechanisms involved in immune responses. Thus, in both birds and mammals, immune responses require a minimal number of steps: 1) Access of antigen to the body, followed by appropriate processing, generally by mononuclear cells. 2) Presentation of antigen to antigen-sensitive small lymphocytes. 3) Response of antigen-sensitive cells to antigen in a specific fashion to generate the effector mechanisms of the immune responses. 4) Rigorous control of responses in order to ensure that they are appropriate both qualitatively and quantitatively. This review follows the immune responses of birds along that basic pathway.
Structural and Molecular Docking Analytical Studies of the Predicted Ligand Binding Sites of Cadherin-1 in Cancer Prognostics

Introduction Several studies have explored the design of antimicrobial peptides (AMPs) for the development of therapeutic and diagnostic molecules for the treatment and identification of pathogenic diseases as well as cancer. Human cadherin-1 protein has been identified to be involved in adhesion-mediated signalling pathways in normal cells and its loss through genetic and epigenetic alterations can result in an enhanced invasion and metastasis of malignancy in tumours. Therefore, the identification of cadherin during treatment of cancer can be used as prognostic biomarker to establish the responsiveness of patients to treatment regimen. Antimicrobial peptides (AMPs) offer several compensatory advantages in biomedical applications and have been used for treatment of diseases, dietary supplements and diagnosis of diseases. The aim of this research work was to use in silico approaches to analyse retrieved human cadherin-1 as prognostic targets in cancer treatments using modelled putative anticancer AMPs. Methods The structures of the putative AMPs and cadherin-1 were modelled using I-TASSER server and the protein overall quality was validated using PROCHECK. Thereafter, the protein motifs were predicted and the molecular interaction between the putative anticancer AMPs and protein was carried out using PatchDock. Results The results revealed that all the AMPs were good prognostic molecules for cancer with BOO1 having the highest binding affinity of 15,874. Conclusion This study revealed that all the generated AMPs have good prognostic value for monitoring the progress of cancer treatment using human cadherin-1 as receptor. This is the first report where AMPs were used in prognostics of cancer using human cadherin-1.
Pediatric Quality Improvement (QI) Virtual Practicum: Adapting a QI Simulator

Introduction Pediatric residencies are expected to arm trainees with skills in quality improvement (QI) that allow trainees to systematically enhance their own practice. Simulation has been shown to be effective in teaching QI, but there are no published QI simulation tools that target pediatric learners. Methods We adapted a previously developed QI simulation to include a case relevant for pediatric residents. Participants devised interventions using basic QI principles with iterative feedback from facilitators with knowledge of QI methodology. Changes in resident knowledge, attitudes about the curriculum, and depth of engagement in QI were assessed using pre- and posttests, surveys, and assessment of independent QI activities performed prior to graduation, respectively. Results Eighty-two residents completed the simulation. Of the 76 residents who completed both the pre- and posttests, which each had a total possible score of 28 points, 68% had improved posttest scores, with an average score increase of 2.6 points (SD = 0.6, p < .001). Improvements were most pronounced for residents that scored in the lowest quartile on the pretest. After the simulation, residents reported greater confidence in and likelihood of completing a QI initiative. There was no difference in the level of involvement in future independent QI activities completed by residents who were simulation participants compared with nonparticipants. Discussion Adapting a previously published QI simulation for pediatric residents was feasible and effective, and the QI simulation was well-liked by learners. Those with lower baseline QI knowledge may have the most to gain from this simulation.
Antipredator Strategies of Female Thomson'S Gazelles with Hidden Fawns

Mothers of young Thomson's gazelles ( Gazella thomsoni ) were distinctive because of their high levels of vigilance. However, they revealed so little information concerning the location of their hidden fawns that it was not profitable for predators to search near them. An alternative strategy, that of waiting for the mother to reveal the position of her fawn at the end of the hiding period, was only worthwhile if the predator remained undetected. Otherwise, gazelle mothers delayed returning to feed their fawns.
Analyse d'images de documents anciens : une approche texture Old document image analysis : a texture approach

and key words In this article, we propose a method of characterization of images of old documents based on a texture approach. This characterization is carried out with the help of a multi-resolution study of the textures contained in the images of the document. Thus, by extracting five features linked to the frequencies and to the orientations in the different areas of a page, it is possible to extract and compare elements of high semantic level without expressing any hypothesis about the physical or logical structure of the analysed documents. Experimentations demonstrate the performance of our propositions and the advances that they represent in terms of characterization of content of a deeply heterogeneous corpus. Document image analysis, Texture features, Multiresolution, digital libraries, indexation.
EFFECT OF EXPLANT SOURCE ON REGENERATION AND GENETIC TRANSFORMATION EFFICIENCY IN GALIA MELON (Cucumis melo L.) MALE AND FEMALE PARENTAL LINES

El objetivo de este trabajo fue investigar la capacidad de regeneracion de plantas in vitro de explantes de cotiledon, hipocotilo y hoja de las lineas parentales masculina y femenina de melon Galia, asi como probar su eficiencia de transformacion por Agrobacterium tumefaciens. Para la transformacion se usaron cepas de A. tumefaciens (ABI y AGL-1) conteniendo plasmidos con el gen reportero uidA que codifica la β-glucuronidasa (GUS), o el gen reportero que codifica la proteina verde fluorescente (GFP). La regeneracion de brotes se consiguio en todos los tipos de explantes utilizados. El mayor indice de la capacidad de formacion de brotes (BFC) fue 6.99; ademas, se obtuvieron GUS positivos de brotes y raices (10.0%) (p≤0.05) a partir de los cotiledones. Los explantes de hipocotilo produjeron el mayor numero de brotes y raices positivos a GFP (13.3%) (p≤0.05). No se regeneraron brotes transgenicos en explantes de hoja con ninguno de los vectores probados. Plantas transgenicas de ambas lineas parentales se regeneraron en 3 a 4 meses utilizando cotiledones, y en 6 a 7 meses usando hipocotilos. El analisis de citometria de flujo demostro que solo 10% de las plantas regeneradas fueron diploides
Evaluation of date fiber as s feed ingredient for Nile tilapia Oreocromis niloticus fingerlings.

This study was carried out to evaluate the use of date fiber (DF) as a feed ingredient for tilapia fingerlings in terms of growth parameters, body composition, anatomical alterations of the intestinal villi. In addition to, pellet strength and bacterial type and population in the test diets. Four isonitrogenous isocaloric diets containing 0, 100, 200 and 300 g kg-1 DF as replacement of wheat bran were fed to triplicate groups of ten O. niloticus fingerlings (0.65 g) in a recirculating water system for 70 days. Fish fed diets contain up to 200 g kg-1 DF had similar growth parameters. Further increase in dietary DF to 300 g kg-1 resulted in significant retardation in all parameters. Body fat was reduced while protein, ash and moisture were increased by DF level. Increasing dietary DF level caused changes in tilapia’s intestinal villi, reduced dietary microbial activity and bacterial population of selected species, and produced stronger pellets.