Miracle-dz/UniFAR-FTUs huggingface dataset:
Secure IoT-Based, Incentive-Aware Emergency Personnel Dispatching Scheme with Weighted Fine-Grained Access Control

Emergency response times following a traffic accident are extremely crucial in reducing the number of traffic-related deaths. Existing emergency vehicle dispatching systems rely heavily on manual assignments. Although some technology-assisted emergency systems engage in emergency message dissemination and path planning, efficient emergency response is one of the main factors that can decrease traffic-related deaths. Obviously, effective emergency response often plays a far more important role in a successful rescue. In this article, we propose a secure IoT-based and incentive-aware emergency personnel dispatching scheme (EPDS) with weighted fine-grained access control. Our EPDS can recruit available medical personnel on-the-fly, such as physicians driving in the vicinity of the accident scene. An appropriate incentive, such as paid leave, can be offered to encourage medical personnel to join rescue missions. Furthermore, IoT-based devices are installed in vehicles or wearable on drivers to gather biometric signals from the driver, which can be used to decide precisely which divisions or physicians are needed to administer the appropriate remedy. Additionally, our scheme can cryptographically authorize the assigned rescue vehicle to control traffic to increase rescue efficacy. Our scheme also takes advantage of adjacent roadside units to organize the appropriate rescue personnel without requiring long-distance communication with a trusted traffic authority. Proof of security is provided and extensive analyses, including qualitative and quantitative analyses and simulations, show that the proposed scheme can significantly improve rescue response time and effectiveness. To the best of our knowledge, this is the first work to make use of medical personnel that are close by in emergency rescue missions.
The synergistic effects of stimulants and parental psychotherapy in the treatment of attention deficit hyperactivity disorder

A 5‐year‐old boy presented with attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder and separation anxiety disorder. The clinical assessment revealed longstanding parent‐child relationship problems, ongoing family stress, and a chronic level of low grade depression in the mother. The treatment approach consisted of drug treatment of the child and long‐term psychotherapy of the mother. At termination symptoms associated with ADHD were markedly reduced and parent‐child relationship problems were no longer evident. It is argued that in a subgroup of children family stress and attachment difficulties may be involved in the development of ADHD. These difficulties should be considered separately in the treatment of children with ADHD, especially if still present after the symptomatic treatment. The treatment outcome raises the question whether or not certain symptoms attributed to ADHD may be reversible, and the long‐term adverse outcome of the condition preventable.
Does the timing of cardiac rehabilitation impact fitness outcomes? An observational analysis

Objectives To ascertain the characteristics associated with delayed cardiac rehabilitation (CR) and determine if an association between CR timing and fitness outcomes exists in patients receiving routine care. Methods The study used data from the UK National Audit of Cardiac Rehabilitation, a data set which captures information on routine CR practice and patient outcomes. Data from 1 January 2012 to 8 September 2015 were included. Logistic regression models were used to explore the relationship between timing of CR and fitness-related outcomes as measured by patient-reported exercise level (150 min/week: yes/no), Dartmouth quality of life physical fitness scale and the incremental shuttle-walk test. Results Based on UK data current CR practice shows that programmes do not always adhere to recommendations on the start of prompt CR, that is, start CR within 28 days of referral (42 days for coronary artery bypass graft (CABG)). Wait time exceeded recommendations in postmyocardial infarction (post-MI), elective percutaneous coronary intervention (PCI), MI-PCI and post-CABG surgery patients. This was particularly pronounced in the medically managed post-MI group, median wait time 40 days. Furthermore, statistical analysis revealed that delayed CR significantly impacts fitness outcomes. For every 1-day increase in CR wait time, patients were 1% less likely to improve across all fitness-related measures (p<0.05). Conclusions With the potential for suboptimal patient outcome if starting CR is delayed, efforts should be made to identify and overcome barriers to timely CR provision.
Private vs. Collective Wine Reputation

Using a hedonic pricing model, this paper investigates the pricing implications of two broadly defined wine reputation strategies: private and collective. While the former consists of an individual quality differentiation strategy relying on an individual wine producer's own reputation, the latter mainly relies on the reputation of a group of wineries belonging to a particular geographic denomination. To this aim, wine purchases made by a nationally representative panel of Italian households were analyzed. Estimates based on quantile regression reveal that the effects of the two reputation strategies (private and collective) have a different weight according to the price segment of the wines in question. While private reputation plays a major role in both low and high priced wines, collective reputation in terms of geographical designations seems especially important for high priced wines.
Binding Site of the Bridged Macrolides in the Escherichia coli Ribosome

ABSTRACT Ketolides represent the latest group of macrolide antibiotics. Tight binding of ketolides to the ribosome appears to correlate with the presence of an extended alkyl-aryl side chain. Recently developed 6,11-bridged bicyclic ketolides extend the spectrum of platforms used to generate new potent macrolides with extended alkyl-aryl side chains. The purpose of the present study was to characterize the site of binding and the action of bridged macrolides in the ribosomes of Escherichia coli. All the bridged macrolides investigated efficiently protected A2058 and A2059 in domain V of 23S rRNA from modification by dimethyl sulfate and U2609 from modification by carbodiimide. In addition, bridged macrolides that carry extended alkyl-aryl side chains protruding from the 6,11 bridge protected A752 in helix 35 of domain II of 23S rRNA from modification by dimethyl sulfate. Bridged macrolides efficiently displaced erythromycin from the ribosome in a competition binding assay. The A2058G mutation in 23S rRNA conferred resistance to the bridged macrolides. The U2609C mutation, which renders E. coli resistant to the previously studied ketolides telithromycin and cethromycin, barely affected cell susceptibility to the bridged macrolides used in this study. The results of the biochemical and genetic studies indicate that in the E. coli ribosome, bridged macrolides bind in the nascent peptide exit tunnel at the site previously described for other macrolide antibiotics. The presence of the side chain promotes the formation of specific interactions with the helix 35 of 23S rRNA.
Online banking in an emerging market: evidence from Saudi Arabia

This paper aims to investigate and identify the adoption characteristics of online banking in one of the largest economies in the Middle East region, namely Saudi Arabia. The study is based on a questionnaire survey directly distributed to Saudi banks' customers in four major cities. The paper employs different statistical techniques such as factor analysis, multivariate analysis of variance and analysis of variance to draw the results. Eight factors including convenience, trust, difficulty, lifestyle, physical contact, complexity, reference group and third party concern are identified. Results indicate that adopters and non-adopters had varied perceptions on factors such as convenience, trust, difficulty, lifestyle, physical contact, complexity and third party concerns. The findings of this study shall enable Saudi banks to have an in-depth understanding of the factors that affect online banking adoption. Banks should refocus their efforts on customers who have not used online banking services by implementing or tailoring their marketing strategies to increase the rate of online usage. Furthermore, by enhancing online banking services, Saudi banks will be able to minimise the number of branch transactions thereby improving banking efficiency, reducing costs, gaining new clients and creating effective customer satisfaction.
Image smoothing and edge detection CMOS sensor array with improved signal output range

This paper consists of design, simulation, layout, and test of a CMOS image sensor array. It is an analog nonlinear circuitry with on-board photoreceptors that acquire and process the image on a single, compact VLSI chip. Spatial image processing chips implementing resistive grid have been broadly explored. One of the main drawbacks of one group of these sensors is the large percentage of analog output signal loss due to the known low CMOS sensors sensitivity and the relative large offset of the readout amplifier caused by run-to-run and in chip process variations. In our design, we modified the pixel circuit and the read out transresistance amplifier gaining back close to fifty percent of the photo signal. The motivation of the overall chip is derived from its neurobiological counterpart. It models the first stage of retinal processing at the first synapse
Optimal distributed generation placement among interconnected cooperative microgrids

The significant technical and economic benefits associated with microgrids have led to vast efforts in expanding their penetration in electric power systems. The benefits, however, must be scrutinized and compared with the huge investment cost to justify future microgrid deployments. There are lots of studies about integrating distributed generation (DG) units into a single microgrid; but DG deployment in cooperative microgrids, which allows power exchange among interconnected microgrids, lacks of study. In this paper, we first study DG placement problem among interconnected cooperative microgrids. In particular, we jointly optimize the long-term DG placement and short-term system operation to minimize microgrids' total operation cost. Uncertainties, including load demands and renewable energy generation, are taken into consideration. By using Branch Flow model, the DG placement problem can be formulated as a stochastic mixed integer convex problem. We propose to solve the problem in two stages: 1) to derive the analytical expression of Optimal Power Flow (OPF) problems for the short-term operation; 2) to solve the remaining integer problem for the long-term planning. Numerical results show that an optimal DG placement can save at most 5.8% of the long-term cost in our case studies.
Subarachnoid Hemorrhage and Inflammation: Bench to Bedside and Back

Subarachnoid hemorrhage (SAH) is a devastating and complicated disease. The development of therapeutic interventions has been hampered by a poor understanding of the three components of the disease pathology in SAH: aneurysm rupture, cerebral edema, and vasospasm. The role of inflammation in the pathology of subarachnoid hemorrhage will be reviewed. The events leading up to aneurysm rupture are heralded by degradation of the endothelial cell layer integrity and inflammatory cell infiltration into the wall of the aneurysm. This is associated with release of active agents that can digest the basement membrane and may cause rupture. After rupture, cytokine release by mononuclear leukocytes is associated with early edema. Vasospasm is a complicated process that includes arterial wall thickening and vasoconstriction. Evidence supports the role of inflammation in free radical formation and in perturbations in nitric oxide and endothelin-1 levels that are important mediators of the vasoconstriction in vasospasm. Targeting the inflammatory mediators associated with the three prominent events in SAH is a promising strategy for reducing the mortality and morbidity in these patients. More study is needed to determine which specific effectors in the inflammatory cascade may serve as targets for intervention.
The Relevance of Qualitative Research for Clinical Programs in Psychiatry

It is time to move beyond education about qualitative research theory and methods to using them to understand and improve psychiatric practice. There is a good fit between this agenda and current thinking about research use that broadens definitions of evidence beyond the results of experiments. This paper describes a qualitative program evaluation to illustrate what kind of useful knowledge is generated and how it can be created through a clinician–researcher partnership. The linkage and exchange model of effective knowledge translation described involves interaction between clinicians and researchers throughout the research process and results in mutual learning through the planning, disseminating, and application of existing or new qualitative research in decision making.
Antimicrobial resistance among Streptococcus pneumoniae in the United States: have we begun to turn the corner on resistance to certain antimicrobial classes?

BACKGROUND Antimicrobial resistance has emerged as a major problem in Streptococcus pneumoniae in the United States during the past 15 years. This study was undertaken to elucidate the current scope and magnitude of this problem in the United States and to assess resistance trends since 1994-1995. METHODS A total of 1817 S. pneumoniae isolates obtained from patients with community-acquired respiratory tract infections in 44 US medical centers were characterized during the winter of 2002-2003. The activity of 27 antimicrobial agents was assessed. In addition, selected isolates were examined for the presence of mutations in the quinolone-resistance determining regions (QRDRs) of parC and gyrA that resulted in diminished fluoroquinolone activity. The results of this survey were compared with the results of 4 previous surveys conducted in a similar manner since 1994-1995. RESULTS Overall rates of resistance (defined as the rate of intermediate resistance plus the rate of resistance) were as follows: penicillin, 34.2%; ceftriaxone, 6.9%; erythromycin, 29.5%; clindamycin, 9.4%; tetracycline, 16.2%; and trimethoprim-sulfamethoxazole (TMP-SMX), 31.9%. No resistance was observed with vancomycin, linezolid, or telithromycin; 22.2% of isolates were multidrug resistant; 2.3% of isolates had ciprofloxacin MICs of >or=4.0 microg/mL. It was estimated that 21.9% of the isolates in this national collection had mutations in the QRDRs of parC and/or gyrA, with parC only mutations occurring most often (in 21% of all isolates). Trend analysis since 1994-1995 indicated that rates of resistance to beta -lactams, macrolides, tetracyclines, TMP-SMX, and multiple drugs have either plateaued or have begun to decrease. Conversely, fluoroquinolone resistance among S. pneumoniae is becoming more prevalent. CONCLUSION It appears that, as fluoroquinolone resistance emerges among S. pneumoniae in the United States, resistance to other antimicrobial classes is becoming less common.
Compact Hyper-Band Printed Slot Antenna With Stable Radiation Properties

A compact hyper-band ( >10:1 impedance bandwidth) printed antenna design is investigated numerically and experimentally. It is based on an elliptical-slot antenna augmented with a parasitic oval patch and driven with a specially engineered microstrip-line-fed elliptical tuning fork element. The parasitic and driven elements are adjusted along with the elliptical slot to create additional resonance modes; adjust the coupling strengths among all of the design components; facilitate the overlap of adjacent resonance modes; and fine tune the input impedance. The total size of the final optimized antenna is only 30 ×40 mm2. It exhibits a -10-dB impedance bandwidth from 2.26 to 22.18 GHz. Desirable radiation performance characteristics, including relatively stable and omni-directional radiation patterns, are obtained over this range. A prototype was fabricated and tested. The experimental results confirm the predicted input impedance bandwidth and radiation characteristics. While the hyper-band performance could be used for high fidelity short pulse applications, the antenna could also be used for multi-band operations from 3.1-10.6 GHz since it covers that entire ultra-wideband (UWB) spectral range.
IDR and YEN Currency With Structural Model

This research aims to investigate a simple algorithm modeling, how the algorithm implementation and development into the structural model in the form of multivariate time series data using Eviews. 2 basic instruments are in use are vector auto regressive (VAR) and vector error correction (VEC) which will be developed into a structural vector auto regressive (SVAR) and structural vector error correction (SVEC). In this study used a variable currency IDR (Indonesia) and YEN (Japan) during the period 2004-2014, which convert into USD. Modeling of basic instruments that created and continue to shape innovative structures, can result in that the VAR model and SVAR be implemented on the stationary, while the VEC and SVEC models can be implemented in the data that are nonstationary.
Postinfusion phlebitis after intravenous push versus intravenous piggyback administration of antimicrobial agents.

The incidence and severity of phlebitis associated with the i.v. push method versus the i.v. piggyback method of administration of antimicrobial agents were evaluated. All patients admitted to two nursing units of an 886-bed, tertiary-care hospital from March through June 1987 who received intravenous cephalosporins or extended-spectrum penicillins were considered for inclusion in the study. The method of administration, either i.v. push or i.v. piggyback, was randomly assigned. Each patient's catheter site was evaluated every 24 hours according to standardized definitions of phlebitis and patency. Information on each patient and venipuncture site also was collected. A total of 319 catheter sites were studied in 155 patients. There was no significant difference in the incidence or severity of postinfusion phlebitis between the i.v. push and the i.v. piggyback groups (41% versus 47%). When studying only those catheter sites discontinued because of phlebitis, the time until development of phlebitis averaged 45 +/- 20.5 hours in the i.v. push group, compared with only 36.2 +/- 17.6 hours in the i.v. piggyback group; this difference was significant. The fact that the catheter sites lasted significantly longer in the i.v. push group, combined with elimination of the cost of syringe infusion pumps or i.v. tubing and minibags, suggests that use of the i.v. push method may result in substantial cost savings. Other advantages associated with the i.v. push method include time savings for nursing personnel and patients and greater ease in scheduling doses of multiple antimicrobial agents. (ABSTRACT TRUNCATED AT 250 WORDS)
Stroke recurrence in patients with recently symptomatic carotid stenosis and scheduled for carotid revascularization

Patients with symptomatic carotid stenosis (sCS) have a higher risk of stroke recurrence following the first ischaemic event. Guidelines recommend that patients undergo carotid revascularization (CR), preferably within 2 weeks of the event. We aimed to determine the rate of stroke recurrence during hospitalization in patients who were admitted to the hospital with an acute ischaemic event and who underwent CR for recently sCS.
Day of the Week Effect in biotechnology stocks: An Application of the GARCH processes

This study examines the presence of the day-of-the-week effect on daily returns of biotechnology stocks over a 16-year period from January 2002 to December 2015. Using daily returns from the NASDAQ Biotechnology Index (NBI), we find that the stock returns were the lowest on Mondays, and compared to the Mondays the stock returns were significantly higher on Wednesdays, Thursdays, and Fridays. Moreover, the results from using the asymmetric GARCH processes reveal that momentum and small-firm effect were positively associated with the market risk-adjusted returns of the biotechnology stocks during this period. The findings of our study suggest that active portfolio managers need to consider the day of the week, momentum, and small-firm effect when making trading decisions for biotechnology stocks.
Homeotic control in Drosophila; the scabrous gene is an in vivo target of Ultrabithorax proteins.

The regulatory functions of transcription factors encoded by the Ultrabithorax (Ubx) gene initiate genetic programmes essential for segmental identity and morphogenesis in Drosophila. Based on the formation of DNA‐protein adducts in intact nuclei and immunoselection procedure, we cloned genomic targets for Ubx proteins. One clone was studied in detail. It encompasses parts of the last intron and exon of the scabrous (sca) gene, which encodes a secreted protein involved in cellular communication during neurogenesis. Five motifs, presenting the ATTA core, which is shared by most homeodomain binding sites, were found in the nucleotide sequence of this clone. We detail here the dynamic pattern of sca transcript accumulation during embryogenesis and show that mutation of Ubx results in the ectopic transcription of sca in the first abdominal segment. We propose that a direct interaction of Ubx with cis‐acting elements in sca negatively regulates the gene. Transcript localization in several combinations of deficiencies in the Bithorax complex (BX‐C) indicates that sca is downregulated by abdominal A (abdA) and Abdominal B (AbdB), and suggests that it is a common target of the three genes of BX‐C.
MicroRNA‐16 affects key functions of human endothelial progenitor cells

The capacity of EPCs to repair injured tissues is limited. The role of miRNAs in EPCs is largely unknown. We tested whether miRNAs may be useful to enhance the regenerative capacity of EPCs. Early EPCs were isolated from human PBMCs, and late EPCs were amplified from enriched human peripheral CD34+ cells. Expression profiles of miRNAs and mRNAs were obtained by microarrays. Among the miRNAs differentially expressed between early and late EPCs, five members of the miR‐16 family (miR‐15a/‐15b/‐16/‐103/‐107) were overexpressed in early EPCs. Web‐accessible databases predicted 375 gene targets for these five miRNAs. Among these, two regulators of cell cycle progression (CCND1 and CCNE1) and one associated gene (CDK6) were less expressed in early EPCs. Administration of anti‐miR‐16 in early EPCs enhanced the expression of these three genes, and administration of pre‐miR‐16 in late EPCs decreased their expression. In early EPCs, antagonism of miR‐16 allowed for cell‐cycle re‐entry, stimulated differentiation, enhanced IL‐8 secretion, and promoted the formation of capillary‐like structures by HUVECs. In conclusion, miR‐16 regulates key biological pathways in EPCs. This may have important implications to enhance the capacity of EPCs to repair injured tissues.