Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical features of Nipah virus encephalitis among pig farmers in Malaysia.

BACKGROUND Between September 1998 and June 1999, there was an outbreak of severe viral encephalitis due to Nipah virus, a newly discovered paramyxovirus, in Malaysia. METHODS We studied the clinical features of the patients with Nipah virus encephalitis who were admitted to a medical center in Kuala Lumpur. The case definition was based on epidemiologic, clinical, cerebrospinal fluid, and neuroimaging findings. RESULTS Ninety-four patients with Nipah virus infection were seen from February to June 1999 (mean age, 37 years; ratio of male patients to female patients, 4.5 to 1). Ninety-three percent had had direct contact with pigs, usually in the two weeks before the onset of illness, suggesting that there was direct viral transmission from pigs to humans and a short incubation period. The main presenting features were fever, headache, dizziness, and vomiting. Fifty-two patients (55 percent) had a reduced level of consciousness and prominent brain-stem dysfunction. Distinctive clinical signs included segmental myoclonus, areflexia and hypotonia, hypertension, and tachycardia and thus suggest the involvement of the brain stem and the upper cervical spinal cord. The initial cerebrospinal fluid findings were abnormal in 75 percent of patients. Antibodies against Hendra virus were detected in serum or cerebrospinal fluid in 76 percent of 83 patients tested. Thirty patients (32 percent) died after rapid deterioration in their condition. An abnormal doll's-eye reflex and tachycardia were factors associated with a poor prognosis. Death was probably due to severe brain-stem involvement. Neurologic relapse occurred after initially mild disease in three patients. Fifty patients (53 percent) recovered fully, and 14 (15 percent) had persistent neurologic deficits. CONCLUSIONS Nipah virus causes a severe, rapidly progressive encephalitis with a high mortality rate and features that suggest involvement of the brain stem. The infection is associated with recent contact with pigs.
Physicians and sleep deprivation.

Correspondence to Lee K. Brown, MD, Professor of Medicine and Pediatrics, Vice Chair, Clinical Program Development, Department of Internal Medicine, University of New Mexico School of Medicine, Executive Director, Program in Sleep Medicine, University of New Mexico Health Sciences Center, 1101 Medical Arts Avenue NE, Building #2, Albuquerque, NM 87102, USA Tel: +1 505 272 6110; fax: +1 505 272 6112; e-mail: lkbrown@alum.mit. edu
Systematic Design of Fully Balanced Differential Current- Mode Multiple-Loop Feedback Filters Using CFBCCII

In this paper, a systematic design method producing balanced current-mode filters is proposed, using current controlled fully balanced second-generation current conveyor circuit (CFBCCII). In this method, many kind of all-pole multiple loop feedback (MF) current mode balanced filters can be obtained, all the produced filters have fully balance structures. Moreover, the frequency of the filters can be electronically adjustable. The produced nth-order filters are constructed by n CFBCCIIs and 2n grounded capacitors, no resistors are needed. The sensitivities of the filters and influences of CFBCCII parasitic elements on filters are analyzed.
Nonclassical Critical Behaviour and Low Temperature Anomalies in Ferroelectric DMACA as Described by Many-Sublattice Model

A model based on the crystallographic data on dimethylammonium nonachlorodiantimonate (DMACA) is constructed. Gradual orientational ordering of three inequivalent sublattices of the dimethylammonium cations is shown to be at the origin of the anomalous behaviour of the spontaneous polarisation in this material. A quantitative comparison with the experimental data reveals a temperature dependence of a coupling between two sublattices and a strong deformability of the underlying structure.
Validade de equações antropométricas para estimar a massa muscular em idosos. DOI:10.5007/1980-0037.2012v14n1p23

O presente estudo objetivou validar equacoes preditivas para estimar a quantidade de massa muscular esqueletica (MME) em idosos. A absorciometria radiologica de dupla energia (DXA) foi adotada como referencia, e utilizada para estimar a MME apendicular, cujos valores foram comparados aqueles, obtidos por equacoes preditivas, que utilizam dados antropometricos, idade, etnia e sexo. A concordância entre os metodos foi verificada pelo teste t pareado, pelo coeficiente de correlacao de Pearson e pela medida de dispersao dos erros, enquanto a comparacao da prevalencia de sarcopenia foi analisada pelo coeficiente de Kappa, pela sensibilidade e especificidade. Foram mensurados 180 idosos (120 mulheres e 60 homens), com idade entre 60 e 81 anos. A quantidade de MME, estimada pela equacao preditiva de Lee et al., nao diferiu daquela obtida pela DXA (p>0,05), e apresentou elevada correlacao, tanto em homens (r=0,90; p<0,001), quanto em mulheres (r=0,86; p<0,001), com significância estatistica. A prevalencia de sarcopenia, tambem, nao diferiu entre os metodos (DXA=33,3% e equacao=36,1%) e apresentou elevados valores de concordância (k=0,74; p<0,001), bem como de especificidade (89%) e de sensibilidade (86%). Conclui-se que a equacoes preditivas, em particular a de Lee et al., sao validas para estimar a quantidade de MME e a prevalencia de sarcopenia, em idosos.
Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk

OBJECTIVE: To describe the association between postmenopausal estrogen-only therapy use and risk of ovarian carcinoma, specifically with regard to disease histotype and duration and timing of use. METHODS: We conducted a pooled analysis of 906 women with ovarian carcinoma and 1,220 women in a control group; all 2,126 women included reported having had a hysterectomy. Ten population-based case–control studies participating in the Ovarian Cancer Association Consortium, an international consortium whose goal is to combine data from many studies with similar methods so reliable assessments of risk factors can be determined, were included. Self-reported questionnaire data from each study were harmonized and conditional logistic regression was used to examine estrogen-only therapy's histotype-specific and duration and recency of use associations. RESULTS: Forty-three and a half percent of the women in the control group reported previous use of estrogen-only therapy. Compared with them, current or recent estrogen-only therapy use was associated with an increased risk for the serous (51.4%, odds ratio [OR] 1.63, 95% confidence interval [CI] 1.27–2.09) and endometrioid (48.6%, OR 2.00, 95% CI 1.17–3.41) histotypes. In addition, statistically significant trends in risk according to duration of use were seen among current or recent postmenopausal estrogen-only therapy users for both ovarian carcinoma histotypes (P trend<.001 for serous and endometrioid). Compared with women in the control group, current or recent users for 10 years or more had increased risks of serous ovarian carcinoma (36.8%, OR 1.73, 95% CI 1.26–2.38) and endometrioid ovarian carcinoma (34.9%, OR 4.03, 95% CI 1.91–8.49). CONCLUSION: We found evidence of an increased risk of serous and endometrioid ovarian carcinoma associated with postmenopausal estrogen-only therapy use, particularly of long duration. These findings emphasize that risk may be associated with extended estrogen-only therapy use.
Dendritic organization of class II (inter)neurons in the dorsal lateral geniculate nucleus of the tree shrew: Observations based on Golgi, immunocytochemical, and biocytin methods

In this report we examine the dendritic organization of putative interneurons (class II cells) in different layers of the dorsal lateral geniculate nucleus of the tree shrew. The results show that there is considerable morphological diversity within this class, but that two broad groups can be identified: neurons whose dendrites remain within a layer or its adjacent interlaminar zones (intralaminar class II cells); and neurons whose dendrites cross into an adjacent layer(s) (interlaminar class II cells). The majority of class II cells in every layer have intralaminar dendrites, some of which are oriented along a particular axis, and others that are organized radially. The paired layers (1 and 2, 4 and 5) contain a particular group of intralaminar class II cells that have radially organized dendrites and elaborate claw‐like appendages. The dendrites of interlaminar class II cells are organized along lines of projection and extend across as many as four layers. These cells often reside close to or within the interlaminar zones. Overall, the organization of class II cells seems to follow a pattern similar to the class I (relay) cells identified previously. Most have intralaminar dendrites, which presumably underlie the fidelity of signals transmitted from the retina to a particular layer. However, there are also a number of other cells whose processes cross laminar borders, presumably to affect integrative functions within the nucleus. © 1992 Wiley‐Liss, Inc.
Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

Introduction of TCR alpha transgene, TCR beta transgene, or both into RAG-2-/-mice differentially rescues T cell development. RAG-2-/- mice have small numbers of TCR-CD4-CD8-(double negative, DN) thymocytes that express CD3 gamma delta epsilon and zeta proteins intracellularly. Introduction of a TCR beta transgene, but not a TCR alpha transgene, into the RAG-2-/- background restored normal numbers of thymocytes. These cells were CD4+CD8+ (double positive, DP) and expressed small amounts of surface TCR beta chain dimers in association with CD3 gamma delta epsilon but not zeta. RAG-2-/- mice that expressed alpha and beta TCR transgenes developed both DP and single positive thymocytes. Thus, the TCR beta subunit, possibly in association with a novel CD3 complex, participates in the DN to the DP transition.
Elevating maternal insulin-like growth factor-I in mice and rats alters the pattern of fetal growth by removing maternal constraint.

Fetal growth is normally constrained by maternal factors. This constraint is demonstrated by the usual inverse linear relationship between litter size and mean fetal weight. Cross-breeding experiments between mice of lines selected for high or low plasma insulin-like growth factor (IGF-I) levels suggested that elevations in maternal IGF-I abolish (P less than 0.01) this constraining effect and reverse the usual positive relationship between fetal and placental size in late gestation. This was confirmed by treating mice and rats throughout pregnancy with IGF-I. In normal mice and in low IGF-I line mice treatment with IGF-I (10 micrograms 8-hourly s.c. from day 1 to 19 of pregnancy) abolished maternal constraint whereas 0.9% (w/v) NaCl treatment did not. In Wistar rats osmotic pumps were implanted to deliver IGF-I (1 microgram/g body weight per day), bovine GH (bGH; 0.6 microgram/g body weight per day) or saline from day 1 to 19 of pregnancy. IGF-I therapy but not bGH or saline abolished (P less than 0.01) maternal constraint and altered (P less than 0.01) the relationship between placental and fetal weight. When high or low IGF-I line mice embroys were transplanted into a normal line of mice, the expected negative relationship (P less than 0.05) between mean fetal weight and litter size was maintained. However, the embryos of the high line were heavier (P less than 0.05) than those from the low line irrespective of fetal number, suggesting a direct role for IGF-I in the regulation of fetal growth. (ABSTRACT TRUNCATED AT 250 WORDS)
Isolated bilateral oculomotor nerve palsy in pituitary apoplexy: case report and review

Pituitary tumours usually present with visual field defects; extraocular palsy is usually a sign of cavernous sinus extension and is a sign of advanced disease. We report a case of a pituitary adenoma presenting with complete, bilateral oculomotor nerve palsies, but minimal loss of visual fields, and intact abducens and trochlear nerves.
Neurobehavioral outcomes of school-age children born extremely low birth weight or very preterm in the 1990s.

CONTEXT The outcome into school age of regional cohorts of children born in the 1990s with birth weights less than 1000 g (extremely low birth weight, ELBW) or earlier than 28 weeks' gestation (very preterm) is not known. OBJECTIVE To determine the cognitive, educational, and behavioral outcome of ELBW or very preterm infants born in the 1990s compared with normal birth weight (NBW) controls. DESIGN Regional cohort study. SETTING Victoria, Australia. PARTICIPANTS The ELBW or very preterm cohort was composed of 298 consecutive survivors born during 1991-1992. The NBW cohort was composed of 262 randomly selected children with birth weights of more than 2499 g. MAIN OUTCOME MEASURES Cognitive ability, educational progress, and behavioral problems. RESULTS The follow-up rates from birth to 8 years of age for survivors were 92.3% (275/298) for the ELBW or very preterm cohort and 85.1% (223/262) for the NBW cohort. The ELBW or very preterm children scored significantly below NBW controls on full-scale IQ (mean difference, -9.4; 95% confidence interval [CI], -12.1 to -6.7; P<.001) and indices of verbal comprehension (mean difference, -6.8; 95% CI, -9.5 to -4.2; P<.001), perceptual organization (mean difference, -9.9; 95% CI, -12.7 to -7.2; P<.001), freedom from distractibility (mean difference, -8.1; 95% CI, -10.8 to -5.5; P<.001), and processing speed (mean difference, -6.7; 95% CI, -9.4 to -4.0; P<.001). The ELBW or very preterm children performed significantly worse than the NBW cohort on tests of reading (mean difference, -6.7; 95% CI, -9.5 to -3.9; P<.001), spelling (mean difference, -5.6; 95% CI, -8.0 to -3.3; P<.001), and arithmetic (mean difference, -8.8; 95% CI, -11.3 to -6.2; P<.001). Attentional difficulties, internalizing behavior problems, and immature adaptive skills were more prevalent in the ELBW or very preterm cohort. CONCLUSION School-aged ELBW or very preterm children born in the 1990s continue to display cognitive, educational, and behavioral impairments.
Statistical methods in epidemiology. II: A commonsense approach to sample size estimation.

PURPOSE It has been argued, by many, that mathematical formulae for estimating sample size are unnecessarily complex, so much so that researchers may be reluctant to seek statistical advice. METHOD This paper reviews methods of sample size estimation arguing that two formulae (one based on comparison of proportion of 'successes', the other based on comparison of means of normally distributed data) suffice for many situations. This paper argues the case by taking examples drawn mainly from clinical trials research. However, the methods outlined can also be used in epidemiology specifically in both case-control and cohort studies with no loss of information. RESULTS For the situations outlined, worked examples are provided. CONCLUSIONS Sample size estimation need not necessarily be a complex process. Simple techniques exist which enable the clinician and the statistician to work together. Continued dialogue between both parties is required so that good ideas do not go to waste.
Simulated weightlessness by tail-suspension affects follicle development and reproductive capacity in rats

Weightlessness is known to induce many pathophysiological changes in various organs and systems in simulated weightlessness animal models. However, there is limited data on the effects of weightlessness on the female reproductive system. In the present study, we used the Morey-Holton hind limb suspension model to simulate weightlessness in female rats. We have shown that this weightlessness induces alterations in follicle development, ovarian hormone secretion, proliferation and apoptosis of granulosa cells, and reproductive capacity. These results demonstrate that simulated weightlessness decreases follicle number, enhances follicular atresia, inhibits granulosa cell proliferation, promotes granulosa cell apoptosis, affects levels of hormone secretion, and significantly decreases reproductive capacity. In addition, our results show that the negative effects of microgravity on the reproductive functions in female rats are reversible when gravity is restored.
Input admittance of circular waveguide opening mounted on dielectric-covered grounded spherical surface

The paper deals with a circular waveguide antenna mounted on a grounded spherical surface with a dielectric coating. The analysis method is based on the moment method in the spectral domain. The influence of thickness and permittivity of dielectric radome is discussed. The analysis method is verified by comparing the theoretical results with measurements.
Pressure-Controlled Palpation: A New Technique Which Increases the Reliability of Manual Palpation

The objective of the present study was to investigate whether the reliability of tenderness evaluation can be increased by using a new technique called “pressure-controlled palpation” (pcp). The technique has been made possible by a newly invented piece of equipment called a palpometer, with which a pressure-sensitive plastic film attached to the index finger records the pressure exerted. In 15 patients with chronic tension-type headache and in 15 healthy volunteers, 2 investigators studied myofascial tenderness using conventional palpation and pressure-controlled palpation. Tenderness was scored on a 4–point scale in each of the examined pericranial regions. The sum of tenderness scores recorded by two observers using conventional palpation differed significantly (p = 0.0003), while results did not differ between observers using pressure-controlled palpation (p = 0.89). During palpation with seven different pressure intensities a positive and linear relation between pressure and pain intensity was found (p = 0.00006). Pain intensity reported by the subjects correlated highly with tenderness scored by the observer (rs = 0.95, p < 0.0001). These results demonstrate for the first time that tenderness scores can be compared between observers if palpation pressure is controlled. Pressure-controlled palpation represents a major improvement on current palpation techniques and should be standard in future research on myofascial pain disorders.
Clinical Management of Babesiosis in Crossbred Dairy Cattle

Four months back calved crossbred dairy cow had history of coffee coloured urine. Blood smear and Blood samples of this cow were collected on the day of acute stage of infection and then 15th day of post treatment for haematological parameters. Based on the clinical pathonomonic symptom (coffee coloured urine) and blood smear examination presence of Babesia bigemina organisms the disease was diagnosed as babesiosis. The animal was treated with inj. diminazene diaceturate 30 ml,i/m ,inj. Chlorpheniraminemaleate 10 ml,i/m:inj.Malexicam 15 ml,i/m and Iron injection 10 ml i/m. After 12 hours treatment the colour of the urine was almost normal and other feeding habits were improved. In posttreatment the haematological parameters were increased with administration of iron as well as diminazene diaceturate compared to stage of infection.
Unconventional therapies in ocular adnexal lymphomas

usually represented by a rituximab–cyclophosphamide–adriamycin–vincristine– prednisone (R-CHOP) regimen. A large proportion of patients are usually treated as a first-line approach with radiotherapy, with obvious implications related to the long-term complications of this strategy.
Initial tumor cell arrest in animals of defined coagulative status

Experiments were made to evaluate the potential role played by thrombogenic factors on the hematogenous arrest of circulating tumor cells in mice with demonstrable coagulopathies associated with the presence of a primary tumor, by administration of “therapeutic” doses of anticoagulants. The effects of warfarin, aspirin and heparin administration on the early arrest patterns of 125IdUrd‐labelled TA3 carcinoma and Gardner lympho‐sarcoma cells injected intravenously into tumor‐bearing mice were examined. Several hematologic parameters of carcinoma‐ and lymphosarcoma‐bearing animals were measured prior to anti‐coagulation experiments and the results indicated that mice had coagulopathies similar to those found in cancer patients with disseminated intra‐vascular coagulation syndrome, i.e., thrombocyto‐penia and elevated fibrinogen levels. Despite the presence of coagulation abnormalities and effective anticoagulation in recipient animals, all three agents were without effect on localization patterns of both tumor types. It was concluded that the proposed involvement of thrombogenesis in metastasis was probably not due to any role played by those clotting factors inhibited by aspirin, warfarin and heparin in early intravascular tumor cell arrest.
Electron transfer flavoprotein from pig liver mitochondria. A simple purification and re-evaluation of some of the molecular properties.

Electron transfer flavoprotein (ETF) from pig liver mitochondria has been purified to homogeneity by a three-step procedure with approx. 10-fold higher yields than previously reported. The purified ETF exhibits an absorption coefficient for the bound FAD of 13.5 mM-1.cm-1 at 436 nm and an isoelectric point of 6.75. Gel filtration, sodium dodecyl sulphate gel electrophoresis and flavin analysis indicate that pig liver ETF is a dimer, composed of non-identical subunits (Mr 38 000 and 32 000) with only one FAD/dimer. Anaerobic reduction by dithionite produces anionic flavin semiquinone as a stable intermediate and establishes the flavin to be the only redox-active chromophore in ETF.
La résorption osseuse péri-implantaire après ostéointégration

L’implantologie est aujourd’hui une discipline couramment utilisee pour la restauration esthetique et fonctionnelle perenne des edentes partiels et totaux. Cependant, des complications primaires (les echecs d’osteointegration) et les peri-implantites entrainent un certain nombre d’echecs implantaires. Les maladies peri-implantaires ont un mecanisme hysiopathologique similaire a celui des maladies parodontales affectant les dents naturelles. Une meilleure connaissance des facteurs influencant l’apparition de ces complications est necessaire, d’autant plus que le nombre de praticiens placant des implants et le nombre de procedures chirurgicales realisees sont en constante augmentation dans le monde. Leur prise en charge precoce est d’autant plus importante que l’arsenal therapeutique pour le traitement des peri-implantites est vaste mais que le succes est pour l’instant loin d’etre garanti. Afin de mieux comprendre ces pathologies, nous aborderons leur prevalence, leur physiopathologie, les facteurs de risques ainsi que leur diagnostic et les modalites de traitement.
MatchingSem: Online recruitment system based on multiple semantic resources

The growth of online recruitment has spurred the need for more effective automated systems. On the one hand, traditional approaches based on keyword-based matching techniques suffer from low precision, i.e. a large fraction of the systems' suggestions are irrelevant. On the other hand, the newer semantics-based approaches are penalized by limitations of the exploited semantic resources, namely semantic knowledge incompleteness and limited domain coverage. In this paper, we present an automatic semantics-based online recruitment system that reuses knowledge captured in multiple existing semantic resources to match between candidate resumes and job posts. In addition, we use statistical-based concept-relatedness measures to alleviate the problem of semantic knowledge incompleteness in the exploited resources. An experimental instantiation of the proposed system has been installed to validate its effectiveness in matching job applicants to job posts.