Miracle-dz/UniFAR-FTUs huggingface dataset:
Atividade antioxidante in vitro e in vivo de análogos sintéticos da curcumina e compostos heterocíclicos

Diabetes mellitus e uma doenca caracterizada por hiperglicemia cronica, resultando em desequilibrio metabolico e estresse oxidativo que promove dano tecidual. O aparecimento dessa patologia esta altamente relacionado aos habitos de vida e alimentares da populacao, sendo de grande interesse a busca por um suplemento alimentar que possa tambem atuar evitando ou diminuindo alteracoes oxidativas em individuos diabeticos. Com base na conhecida acao antioxidante apresentada pela curcumina, objetivou-se nesse trabalho avaliar, in vitro, a atividade antioxidante de uma serie de analogos sinteticos da curcumina, bem como de novas estruturas quimicas heterociclicas tiazolicas, e selecionar a substância mais promissora para estudos adicionais in vivo. As analises in vitro foram feitas pelos metodos ABTS, captura do radical DPPH e Reducao de Ferro (FRAP). A partir dos resultados obtidos, um heterociclo tiazolico sintetico, RI46, foi selecionado para estudos in vivo, considerando potencia, facilidade de sintese e baixa citotoxicidade. A curcumina foi utilizada como controle positivo tanto nos ensaios in vitro quanto in vivo. Nos estudos in vivo, foram utilizados os extratos hepaticos de ratos Wistar saudaveis e diabeticos, com analises de determinacao da atividade enzimatica de SOD, CAT, GPx e GR, e determinacao da peroxidacao lipidica pelo teste TBARS; no sangue desses animais foram analisados os parâmetros bioquimicos: hemoglobina, colesterol total, colesterol HDL, triglicerides, ALT, AST, fosfatase alcalina, ureia, proteinas totais, creatinina, magnesio, acido urico, amilase e albumina. Os resultados foram submetidos a analise de variância ANOVA e as medias dos tratamentos foram comparadas pelo teste de Tukey (p = 0,05). Nao foram detectadas evidencias estatisticas de alteracoes causadas nas enzimas hepaticas e no nivel de peroxidacao lipidica apos tratamento com RI46 ou curcumina, entretanto, esses parâmetros tambem nao estavam alterados quando comparados os grupos controle sem e com diabetes. Por outro lado, com relacao aos parâmetros bioquimicos, houve diferencas significativas para acido urico, fosfatase alcalina, ALT e ureia, demonstrando um possivel papel protetor antioxidante dessas substâncias no figado e nos rins dos animais diabeticos que poderia estar agindo por outras vias que nao as comumente relatadas na literatura.
Evaluating the chemical composition and antioxidant activity of three Egyptian seaweeds: Dictyota dichotoma, Turbinaria decurrens, and Laurencia obtusa

Abstract Seaweeds have a growing number of successful applications in the food industry, medicine and in the cosmetic industry, which increases the importance of evaluating their chemical composition. In the present study, three common Egyptian seaweeds (Dictyota dichotoma, Turbinaria decurrens and Laurencia obtusa) were collected from the Red Sea coast, Suez, Egypt. The chemical profile of the three seaweeds was studied beside the antioxidant activity of their extracts. The results indicated that the amount of carbohydrate was greater than the protein and lipid contents in the three seaweeds, with a natural richness in minerals and antioxidants besides considerable amounts of monounsaturated and polyunsaturated fatty acids, including Omega-3 and Omega-6 fatty acids. All essential amino acids for human were found in the three seaweeds, with significant amounts of aspartic and glutamic acids. Furthermore, the results of the antioxidant activity assays were consistent with the antioxidant contents (phenols, flavonoids, alkaloids, vitamin C, carotenoids) of each seaweed. D. dichotoma was the most valuable seaweed of the three species studied, due to its relatively high protein content of 7.28 ± 0.25%, moderate carbohydrate content of 25.35 ± 0.32%, and highest pigment and antioxidant contents. In conclusion, these three seaweeds, especially Dictyota dichotoma, have an interesting chemical composition with a prospective nutritional and pharmaceutical value.
ACUTE TOXICOLOGICAL INVESTIGATION OF POLYETHYLENE GLYCOL DERIVATIZED FOURTH AND FIFTH GENERATION POLY (PROPYLENEIMINE) DENDRIMERS

Objective: The aim of the present study leads a comparative assessment of the toxicological profile of PEGylated fourth and fifth-generation poly (propylene imine) dendrimers (PPI). Methods: 4.0G and 5.0G generations of PPI dendrimer were synthesized and PEGylated with Mono polyethylene glycol 5000 (MPEG-5000). Each PEGylated 4.0G and 5.0G dendrimeric generation were administered in three different doses: 2.5 mg/kg, 25 mg/kg and 250 mg/kg (i.e., low, intermediate and high dose) to wister rats. After the dose administration, the blood and tissue samples of wister rats were collected after 24 h and 15 d after. All the collected samples were proceeded for hematological, biochemical and histopathological studies. Results: After 24 h of (250 mg/kg) dose administration PEGylated 5.0G PPI dendrimer the RBC count, hemoglobin content and WBC count were found 7.873±0.129 mill/cmm, 13.833±0.491g/dl and 9033.33±2384.906 mill/cmm, while PEGylated 4.0G PPI dendrimer indicated RBC count, hemoglobin content and WBC count 8.733±0.239 mill/cmm, 14.033±0.12 g/dl and 9666.667±2567.316 mill/cmm, in blood samples as compare to RBC count 9.346±0.037 mill/cmm, hemoglobin content 15.35±0.15 g/dl and WBC count 8500±286.675 mill/cmm of the animals of normal control group. Thus there are no remarkable changes (p>0.05) in RBC count, hemoglobin content and other hematological profile after 24 h in comparison of normal control group of animals. Similarily insignificant changes (p>0.05) in serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), lactate dehydrogenase (LDH) and sections of different organs indicate inoffensive nature of both generations of PEGylated 4.0G and 5.0 G PPI dendrimers. Conclusion: It can be concluded that fifth-generation PPI dendrimers are more suitable as compared to fourth generation of PPI dendrimer, while both dendrimers are not generating any severe toxicity.
Shoulder complaints : the occurence, course and diagnosis

textabstractShoulder complaints are expressed in a variety of symptoms. In many cases, the prominent symptom is pain. In some cases, pain is present most of the day and frequently also at night. In other cases, it is provoked primarily by physical activities. Often it is accompanied by restricted range in shoulder movement. This inhibit people in their daily lives by reducing their ability to use their arm in activities such as dressing, personal hygiene, work, household activities, hobbies and sports. These shoulder symptoms may also lead to sick leave, bringing costs to the workers themselves, as well as to employers and society. Although these are a common musculoskeletal complaint, the estimated prevalence of shoulder complaints varies considerably.
A Theoretical Solution for Ventricular Septal Defects And Pulmonary Vein Stenosis

Ventricular Septal Defects (VSD) and Pulmonary Vein Stenosis (PVS) are both normally non- life- threatening problems for survivors of early childhood. However, it can be a large hindrance to many patients who want a normal life. With this proposed solution, patients should be able to achieve a life mostly free of problems. Hopefully, only regular check-ups will be required after the initial treatment.
Cavity Filtering Magic-T and Its Integrations Into Balanced-to-Unbalanced Power Divider and Duplexing Power Divider

In this article, a cavity filtering magic-T based on three fundamental modes, namely, TE011, TE101, and TM110, in a single triple-mode resonator (TMR) is presented. Taking advantage of the magic-T concept, two types of cavity-based filtering power dividers (PDs) integrated with balanced and duplexing functions are investigated. For the first design of a balanced-to-unbalanced (B2U) PD, balanced functions are integrated at input ports. Three fundamental modes provide the odd- and even-symmetric field distributions so that in-phase and out-of-phase responses at output ports can be achieved. Meanwhile, the common-mode suppression can be achieved at the balanced ports, and high isolation is achieved at the single-end ports, respectively. For the second design of a duplexing PD, instead of using resistors for output ports isolation, isolated ports are applied for magic-Ts to achieve all ports impedance matched and high isolation between channels of the proposed duplexing PD. To verify the concept, a B2U PD and a duplexing PD are fabricated and tested. Good matching between simulated and measured results shows the accuracy of the proposed design methodologies.
Reciprocating engines as a source of flexibility in a power system

In recent years, flexibility of power generation systems – understood as their ability to perform quick start-ups, shut-downs and load changes in possibly broad range and with small loss of efficiency – has been seen as increasingly important. This is due to increased popularisation of wind and solar power generation systems, which operate at variable and not fully predictable output. This creates a demand for power sources able to quickly replace temporarily lost (reduced) output of renewables, which would be characterised by low fixed cost (due to relatively low capacity utilisation factor). The paper presents the newest technical achievements in the field of large reciprocating internal combustion engines used to meet this kind of demand – including technical parameters of current and prospective solutions, as well as operating experience from plants used to provide backup power, along with results of tests confirming ability of engine-based power generation systems to provide ancillary services (primary and secondary frequency control). Also discussed are results of selected techno-economic analyses which highlight system-level benefits resulting from building high-flexibility sources in various power systems, and economic conditions necessary to adopt such technologies. Incentives and obstacles for development of such technologies at the Polish and European energy markets are presented along with different commercial concepts for plants ensuring power flexibility based on examples from different countries.
Suppression of Spatial and Temporal Noise in a CMOS Image Sensor

This paper presents methodologies for suppressing the spatial and the temporal noise in a CMOS image sensor (CIS). First of all, it demonstrates by using a longer-length column bias transistor, both the fixed pattern noise (FPN) and temporal noise can be suppressed. Meantime, it employs column-level oversampling delta-sigma ADCs to suppress temporal noise as well as to facilitate the realization of the thermal compensation of dark signal non-uniformity (DSNU). In addition, the image pixels are re-configured as temperature sensors with inaccuracies within ±0.65 °C, between −20 and 80 °C. If the dark current and its non-uniformities are caused by thermal gradients, the obtained in-pixel thermal information can be employed to compensate for the measured dark current by 95 % and DSNU, up to 13 %. All the column-level 13 bit 2<sup>nd</sup>-order incremental delta-sigma ADCs are measured with SNR around 65 dB and INL around 1.5 LSB, when tested with a −8 dB input signal and sampling at 2 MHz with an oversampling ratio (OSR) of 128, when the full scale voltage is 2 Vp-p. The 4T Pinned Photodiode (PPD) CIS is measured to have a temporal noise of <inline-formula> <tex-math notation="LaTeX">$34~\mu \text{V}$ </tex-math></inline-formula> rms (with an OSR of 128, or, an input referred temporal noise of 0.5 e<sup>−</sup> rms, with a conversion gain, CG, of <inline-formula> <tex-math notation="LaTeX">$73~\mu \text{V}/ \text{e}^{-}$ </tex-math></inline-formula>), a column gain FPN of 0.06 %, a dynamic range (DR) of 92 dB (with OSR = 512), as well as a linearity of 1 %. It has a measured DSNU of 3.2 %, after the thermal compensation using the in-pixel temperature sensors, a dark current of 290 pA/cm<sup>2</sup> and 15 pA/cm<sup>2</sup>, measured at 60 °C, before and after the thermal compensation, respectively.
PCB/Microstrip Antenna Design and Simulation

The paper will give insights on the different types of printed circuit board (PCB) antennas. The study will also explain why the PCB antenna is continuously being developed. The paper will also explain how PCB antennas work. This research aims to create and simulate a working Printed circuit board antenna design. The study will be implemented using MATLAB and its toolboxes. The simulation will focus on the practicality of a PCB antenna and will show how it functions. The design of the PCB antenna will show the basic implementation of a smartphone antenna. The data that will be gathered will show how a smartphone antenna works in the real world. Through the data and results presented in the paper, the concept of how the signal transmission works within smartphones and how data is being sent and received will be explained. The study will give insights on how to improve upon current PCB antennas and what factors should be worked on to make more accurate, efficient and cost-efficient.
Aplicação de SDN no gerenciamento de perfis de usuário em dispositivos de rede

Software Defined Networks (SDN) isolate the control plane from the data plane, allowing a global view of the network and providing a high level programmable network. This can be very useful for managing network access control by associating device flows to user profiles. This paper proposes a tool for managing user profiles by authorizing device flows using software-defined networks. This tool has been implemented on the OpenFlow controller POX. In this paper we describe the experiments performed and the results obtained, which show the efficacy and the ease of use of the mechanism.
Image inverting interferometer for extra-solar planet detection

In the last thirty years, thousands of extra-solar planets have been detected. The overwhelming majority of these detections were performed by indirect techniques. Only a few tens have been detected by direct methods, because the current technology limitations. The rotational shearing interferometer (RSI) has been proposed as a promising technique for the direct detection of extra-solar planets. The RSI is insensitive to rotationally symmetrical wavefronts. This feature allows it to distinguish between a symmetrical wavefront generated by an star alone and an asymmetrical wavefront generated by a star-planet system. However the aperture and resolution of this method is limited by the size of the Dove prisms. We propose the use of an image-inverting interferometer (III) as alternative to the RSI. The III is equivalent to a RSI with a rotation of pi. It conserves the detection features of the RSI. Additionally the III uses mirrors instead Dove prisms avoiding its size limitations.
A Fokker–Planck approach to a moment closure for mixing in variable-density turbulence

ABSTRACT We develop a theory for the cascade mixing terms in a moment closure approach to binary active scalar mixing in variable-density turbulence. To address the variable-density complications we apply, as a principle and constraint, the conservation of the probability density function (PDF) through a Fokker–Planck equation with bounded sample space whose attractor is the beta PDF with skewness. Mixing is related to a single-point PDF as a realisability principle to provide mathematically rigorous expressions for the small scale statistics in terms of largescale moments. The problem of the unknown small-scale mixing is replaced with the determination of the drift and diffusion terms of a Fokker–Planck equation in a beta-PDF-convergent stochastic process. We find that realisability of a beta-convergent process requires the mixing time-scale ratio, taken as a constant in passive scalar mixing, to be a function of the mean mass fraction, mean fluid density, the Atwood number, the density-volume correlation and moments of the density field. We develop and compare the new model with direct numerical simulations data of non-stationary homogeneous variable-density turbulence.
HIGH-FREQUENCY FILTERS MANUFACTURED USING HYBRID 3D PRINTING METHOD

In this work, two different high-frequency filters were produced, and each was manufactured in two different ways, one using conventional PCB technology and the other using hybrid 3D printing. The hybrid 3D printing technique combined the use of microdispensing of conductive inks and fused filament fabrication (FFF) of thermoplastic substrates. Measurements, properties, and comparisons between these filters are discussed. The goal of the research was to benchmark 3D printing of highfrequency filters to more confidently manufacture sophisticated devices and high-frequency systems by hybrid 3D printing.
On generalizing the foldover technique to 3^{f-s} regular fractional factorial designs

The foldover technique allows for an expansion of a fractional factorial experiment with two level factors to achieve a resolution IV design from a resolution III design. Resolution IV designs allow for unbiased estimation of main effects if third order interactions and higher are 0. This paper lays out a scheme that generalizes the foldover technique to regular fractional factorial experiments with three level factors by augmenting the design matrix by a rotation vector. The criterion for choosing an optimal rotation vector is discussed in detail. It is shown that no perfect analog exists to always achieving resolution IV designs for regular fractional factorial experiments with three level factors although minimum aberration can be gained in all situations where resolution IV designs are not available.
Cyclone impact on sea ice in the central Arctic Ocean: a statistical study

This study investigates the impact of cyclones on the Arctic Ocean sea ice for the first time in a statistical manner. We apply the coupled ice–ocean model NAOSIM which is forced by the ECMWF analyses for the period 2006–2008. Cyclone position and radius detected in the ECMWF data are used to extract fields of wind, ice drift, and concentration from the ice–ocean model. Composite fields around the cyclone centre are calculated for different cyclone intensities, the four seasons, and different sub-regions of the Arctic Ocean. In total about 3500 cyclone events are analyzed. In general, cyclones reduce the ice concentration in the order of a few percent increasing towards the cyclone centre. This is confirmed by independent AMSR-E satellite data. The reduction increases with cyclone intensity and is most pronounced in summer and on the Siberian side of the Arctic Ocean. For the Arctic ice cover the cumulative impact of cyclones has climatologic consequences. In winter, the cyclone-induced openings refreeze so that the ice mass is increased. In summer, the openings remain open and the ice melt is accelerated via the positive albedo feedback. Strong summer storms on the Siberian side of the Arctic Ocean may have been important contributions to the recent ice extent minima in 2007 and 2012.
Deep Hashing for Speaker Identification and Retrieval

Speaker identification and retrieval have been widely used in real applications. To overcome the inefficiency problem caused by real-valued representations, there have appeared some speaker hashing methods for speaker identification and retrieval by learning binary codes as representations. However, these hashing methods are based on i-vector and cannot achieve satisfactory retrieval accuracy as they cannot learn discriminative feature representations. In this paper, we propose a novel deep hashing method, called deep additive margin hashing (DAMH), to improve retrieval performance for speaker identification and retrieval task. Compared with existing speaker hashing methods, DAMH can perform feature learning and binary code learning seamlessly by incorporating these two procedures into an end-to-end architecture. Experimental results on a large-scale audio dataset VoxCeleb2 show that DAMH can outperform existing speaker hashing methods to achieve state-of-the-art performance.
Caracterização in situ dos orientadores de axônio por repulsão (RGMs) na musculatura esquelética, e caracterização funcional do membro A (RGMa) durante a miogênese em camundongos

Orientadores de axonio por repulsao (RGMs) sao moleculas que atuam como pistas negativas para orientar o crescimento axonal durante o desenvolvimento embrionario, permitindo a correta inervacao dos tecidos e orgaos. A familia RGM e composta por quatro membros: RGMa, RGMb, RGMc e RGMd. Novas evidencias tem sugerido possiveis papeis para estas RGMs durante o desenvolvimento e manutencao da musculatura esqueletica em vertebrados. RGMa e RGMb foram encontrados na regiao dos somitos onde se originam os precursores miogenicos e celulas satelites. Evidencias tambem sugerem a presenca dessas moleculas nas celulas musculares esqueleticas de camundongos adultos. No presente estudo, procuramos (1) determinar a localizacao de RGMa, RGMb e RGMc nas celulas musculares esqueleticas de camundongos adultos; e (2) investigar os efeitos da super-expressao e knockdown de RGMa nas celulas musculares esqueleticas in vitro. RGMa, RGMb e RGMc foram encontradas no sarcolema. RGMa tambem foi observada no sarcoplasma, onde apresentou um padrao estriado de marcacao, semelhante as proteinas sarcomericas. Foi possivel co-localizar RGMa com proteinas sarcoplasmaticas conhecidas, sugerindo que este orientador de axonio atue como uma proteina sarcoplasmatica. Ensaios de western blot revelaram a presenca de dois peptideos para RGMa em amostras de musculo esqueletico adulto, um de 60 e outro de 33 kDa. A funcao biologica de RGMa em celulas musculares esqueleticas foi investigada em celulas da linhagem C2C12 e mioblastos primarios. A super-expressao de RGMa in vitro promoveu o aparecimento de celulas mais largas, hipertroficas, em sua maioria miotubos; enquanto o knockdown de RGMa resultou em celulas menores, atroficas, com morfologia tipica de mioblastos indiferenciados. O knockdown de RGMa bloqueou a formacao de miotubos, uma vez que, interferiu na fusao dos mioblastos. Nossos resultados sao os primeiros a mostrar uma molecula orientadora de axonio como uma proteina sarcoplasmatica e a incluir RGMa nos sistemas que regulam o tamanho e a diferenciacao da celula muscular esqueletica in vitro.
Continuous Incident Triage for Large-Scale Online Service Systems

In recent years, online service systems have become increasingly popular. Incidents of these systems could cause significant economic loss and customer dissatisfaction. Incident triage, which is the process of assigning a new incident to the responsible team, is vitally important for quick recovery of the affected service. Our industry experience shows that in practice, incident triage is not conducted only once in the beginning, but is a continuous process, in which engineers from different teams have to discuss intensively among themselves about an incident, and continuously refine the incident-triage result until the correct assignment is reached. In particular, our empirical study on 8 real online service systems shows that the percentage of incidents that were reassigned ranges from 5.43% to 68.26% and the number of discussion items before achieving the correct assignment is up to 11.32 on average. To improve the existing incident triage process, in this paper, we propose DeepCT, a Deep learning based approach to automated Continuous incident Triage. DeepCT incorporates a novel GRU-based (Gated Recurrent Unit) model with an attention-based mask strategy and a revised loss function, which can incrementally learn knowledge from discussions and update incident-triage results. Using DeepCT, the correct incident assignment can be achieved with fewer discussions. We conducted an extensive evaluation of DeepCT on 14 large-scale online service systems in Microsoft. The results show that DeepCT is able to achieve more accurate and efficient incident triage, e.g., the average accuracy identifying the responsible team precisely is 0.641~0.729 with the number of discussion items increasing from 1 to 5. Also, DeepCT statistically significantly outperforms the state-of-the-art bug triage approach.