Miracle-dz/UniFAR-FTUs huggingface dataset:
The Association of Serum Testosterone Levels With Recurrence and Mortality After Acute Ischemic Stroke in Males

The current study aimed to investigate whether low testosterone predicted the recurrence and clinical outcomes after acute ischemic stroke (AIS) in males. From June 2015 through August 2017, the study prospectively enrolled 110 male AIS patients. All received detailed evaluations at admission and were followed for at least 1 year. The cumulative incidence, overall survival, length of hospital stay, and the percentage of previous stroke were compared between subjects with testosterone <440 ng/dl and >440 ng/dl. The median age was 62 years (range, 35–93 years). The median serum testosterone at admission was 438 [203] ng/dl (range, 44–816 ng/dl); 55 patients (50%) had testosterone <440 ng/dl and were considered as low testosterone. The median follow-up was 23 months. During the period, 12 recurrences and 10 deaths occurred. The 1-year and 3-year cumulative recurrence rate were 8.3% and 11.9%, respectively; the 1-year and 3-year overall survival were 96.3% and 84.6%, respectively. The cumulative recurrence rates were similar between the two testosterone groups (log-rank test, p = .88). Low testosterone was associated with poor survival with marginal significance (log-rank test, p = .079). Men with low testosterone had a higher percentage of previous stroke (29.1% versus 12.7%, p = .035). The mean lengths of hospital stay were similar between the two testosterone groups (16.6 ± 15.8 days versus 14.0 ± 10.6, p = .31). Total testosterone at admission fails to predict stroke recurrence. However, men with low testosterone at admission are more likely to have previous stroke and may have a higher all-cause mortality rate after AIS.
The DNA Damage Response Mediator MDC1 Directly Interacts with the Anaphase-promoting Complex/Cyclosome*

MDC1 (NFBD1), a mediator of the cellular response to DNA damage, plays an important role in checkpoint activation and DNA repair. Here we identified a cross-talk between the DNA damage response and cell cycle regulation. We discovered that MDC1 binds the anaphase-promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase that controls the cell cycle. The interaction is direct and is mediated by the tandem BRCA1 C-terminal domains of MDC1 and the C terminus of the Cdc27 (APC3) subunit of the APC/C. It requires the phosphorylation of Cdc27 and is enhanced after induction of DNA damage. We show that the tandem BRCA1 C-terminal domains of MDC1, known to directly bind the phosphorylated form of histone H2AX (γ-H2AX), also bind the APC/C by the same mechanism, as phosphopeptides that correspond to the C termini of γ-H2AX and Cdc27 competed with each other for the binding to MDC1. Our results reveal a link between the cellular response to DNA damage and cell cycle regulation, suggesting that MDC1, known to have a role in checkpoint regulation, executes part of this role by binding the APC/C.
Diversity and seasonal variation of ground and understory spiders from a tropical mountain cloud forest

We made intensive samplings to study the seasonal response of spiders across different forest strata (ground and understory) in a tropical mountain cloud forest from Mexico. We sampled spiders from ten plots in six sampling events during the dry and rainy season, to analyze their abundance, structure (distribution of abundance among species), diversity and the response of the five dominant species at each stratum. Results demonstrated that seasonal patterns of spider communities differed among strata, revealing a complex spatiotemporal dynamic. Abundance, structure, diversity of ground spiders, as well as the responses of four dominant species at this stratum, showed low seasonal variations. In contrast, a strong seasonal variation was observed for the understory assemblage, with lowest abundance and highest diversity in the rainy season, and different assemblage structures for each season. Seasonal patterns of each assemblage seem linked to the responses of their dominant species. We found high co‐occurrence among most of the ground dominant species with similar habitat use and with multivoltine patterns, contrasting with low co‐occurrence among most of the understory dominant species with similar habitat use and univoltine patterns. Our results showed that the spiders’ assemblages of tropical mountain cloud forest (opposed to what is found in temperate and boreal forests) increase their species richness with the height, and that their responses to seasonal change differ between strata. Management programs of these habitats should consider the spatial and temporal variations found here, as a better understanding of their ecological dynamics is required to support their sustainable management.
Influence of verification bias on the assessment of MRI in the diagnosis of meniscal tear.

OBJECTIVE Previous studies of the sensitivity and specificity of MRI in the diagnosis of meniscal tear have not included correction for verification bias. The purpose of this study was to investigate the extent to which verification bias affected assessment of the utility of MRI in the diagnosis of meniscal tear. MATERIALS AND METHODS The patients included in the study were outpatients who from April 2006 through July 2008 consecutively visited a single institution for MRI of the meniscus for evaluation of knee pain. For patients who underwent arthroscopy in addition to MRI, the sensitivity and specificity of MRI were calculated. Global sensitivity analysis of data on patients who did not undergo arthroscopy was performed to estimate the influence of verification bias. Global sensitivity analysis is a method for graphically determining whether a particular pair of sensitivity and specificity estimates is compatible with observed data. RESULTS Eighty-two patients (23%) underwent arthroscopic verification. The sensitivity and specificity of MRI were 85% and 31%. When the possibility of meniscal tears in patients who did not undergo arthroscopy was subjected to global sensitivity analysis, the sensitivity of MRI ranged from 29% to 95% and the specificity ranged from 3% to 92%. All combinations of sensitivity and specificity produced a butterfly-shaped curve, but the base case was not inside the curve. CONCLUSION Verification bias greatly affected assessment of the utility of MRI in the diagnosis of meniscal tear. Sensitivity and specificity from previous studies may be incompatible with our data owing to verification bias.
A Structure-Based Human Facial Age Estimation Framework Under a Constrained Condition

Developing an automatic age estimation method toward human faces continues to possess an important role in computer vision and pattern recognition. Many studies regarding facial age estimation mainly focus on two aspects: facial aging feature extraction and classification/regression model learning. To set our work apart from existing age estimation approaches, we consider a different aspect—system structuring, which is under a constrained condition: given a fixed feature type and a fixed learning method, how to design a framework to improve the age estimation performance based on the constraint? We propose a four-stage fusion framework for facial age estimation. This framework starts from gender recognition, then goes to the second phase, gender-specific age grouping, followed by the third stage, age estimation within age groups, and finally ends at the fusion stage. In the experiment, three well-known benchmark datasets, MORPH-II, FG-NET, and CLAP2016, are adopted to validate the procedure. The experimental results show that the performance can be significantly improved by using our proposed framework and this framework also outperforms several state-of-the-art age estimation methods.
Norcantharidin Suppresses YD-15 Cell Invasion Through Inhibition of FAK/Paxillin and F-Actin Reorganization

Norcantharidin (NCTD), a demethylated derivative of cantharidin, has been reported to exhibit activity against various types of cancers. However, the anti-invasive effects of NCTD and its molecular mechanism in human mucoepidermoid carcinoma (MEC) remain incompletely elucidated. Clonogenic, wound healing, invasion, zymography, western blotting and immunocytochemistry assays were performed in YD-15 cells to investigate the anti-invasive effect of NCTD and its molecular mechanism of action. The inhibitory effects of NCTD on invasiveness were compared with those of a novel focal adhesion kinase (FAK) kinase inhibitor, PF-562271. NCTD markedly suppressed the colony formation, migration, and invasion of YD-15 cells as well as the activities of MMP-2 and MMP-9. It disrupted F-actin reorganization through suppressing the FAK/Paxillin axis. Moreover, NCTD exhibited a powerful anti-invasive effect compared with that of PF-562271 in YD-15 cells. Collectively, these results suggest that NCTD has a potential anti-invasive activity against YD-15 cells. This study may clarify the impact of NCTD on migration and invasion of human MEC cells.
Neuropeptide tyrosine (NPY)‐like immunoreactivity in adrenal chromaffin cells and intraadrenal nerve fibers of rats

The present peroxidase‐antiperoxidase immunohistochemical study demonstrated that approximately 50% of the total chromaffin cells of the rat adrenal medulla exhibited NPY‐like immunoreactivity. The immunoreactive material was localized in the core of the chromaffin granules as well as diffusely in the cytoplasm. By combination of immunohistochemistry with noradrenaline‐fluorescence microscopy, all NPY‐immunoreactive chromaffin cells are nonfluorescent, indicating that all NPY‐chromaffin cells co‐store adrenaline. A comparison of two consecutive sections, each of which was processed for the immunostaining with anti‐NPY and anti‐Met‐Enk‐Arg‐Gly‐Leu antisera, respectively, indicated that NPY and preproenke‐phalin A and its derivatives coexist in approximately one‐fifth of the total NPY‐immunoreactive cells.
Circulating microparticles in cardiovascular disease: implications for atherogenesis and atherothrombosis

Summary. The complex and multifactorial nature of atherogenesis and development of atherothrombotic complications involves numerous interactions between various cell types inside the vascular wall (e.g. macrophages and smooth muscle cells) and in the blood (e.g. leukocytes and platelets). One relatively recent advance in this area is the discovery of circulating microparticles and their role in endothelial damage, platelet activation, hypercoagulability and regulation of inter‐cellular interactions. Microparticles are small anucleoid phospholipid vesicles released from different cells, such as platelets, erythrocytes, leukocytes and endothelial cells. Microparticles carry surface proteins and include cytoplasmic material of the parental cells responsible for the exertion of microparticle‐mediated biological effects. About 25% of the procoagulant activity of stimulated platelet suspensions is associated with microparticles released upon platelet activation and their surface may be approximately 50–100‐fold more procoagulant than the surface of activated platelets per se. The available lines of evidence indicate that shedding of microparticles from the parental cells is not just a passive process accompanying cellular dysfunction and apoptosis, but a tightly regulated mechanism implicated in the interactions between various cell types. The role of microparticles as biological messengers is supported by their differential and specific involvement in the pathophysiology of different cardiovascular disorders, including atherogogenesis and thrombosis.
Lung deposition patterns of MWCNT vary with degree of carboxylation

Abstract Functionalization of multi-walled carbon nanotubes (MWCNT) is known to affect the biological response (e.g. toxicity, inflammation) in vitro and in vivo. However, the reasons for these changes in vivo are not well described. This study examined the degree of MWCNT functionalization with regard to in vivo mouse lung distribution, particle retention, and resulting pathology. A commercially available MWCNT (source MWCNT) was functionalized (f-MWCNT) by systematically varying the degree of carboxylation on the particle’s surface. Following a pilot study using seven variants, two f-MWCNT variants were chosen and for lung pathology and particle distribution using oropharyngeal aspiration administration of MWCNT in Balb/c mice. Particle distribution in the lung was examined at 7 and 28 days post-instillation by bright-field microscopy, CytoViva hyperspectral dark-field imaging, and Stimulated Raman Scattering (SRS) microscopy. Examination of the lung tissue by bright-field microscopy showed some acute inflammation for all MWCNT that was highest with source MWCNT. Hyperspectral imaging and SRS were employed to assess the changes in particle deposition and retention. Highly functionalized MWCNT had a higher lung burden and were more disperse. They also appeared to be associated more with epithelial cells compared to the source and less functionalized MWCNT that were mostly interacting with alveolar macrophages (AM). These results showing a slightly reduced pathology despite the extended deposition have implications for the engineering of safer MWCNT and may establish a practical use as a targeted delivery system.
A Work Efficient Parallel Algorithm for Exact Euclidean Distance Transform

A fully-parallelized work-time optimal algorithm is presented for computing the exact Euclidean Distance Transform (EDT) of a 2D binary image with the size of <inline-formula> <tex-math notation="LaTeX">$n\times n$ </tex-math></inline-formula>. Unlike existing PRAM (Parallel Random Access Machine) and other algorithms, this algorithm is suitable for implementation on modern SIMD (Single Instruction Multiple Data) architectures such as GPUs. As a fundamental operation of 2D EDT, 1D EDT is efficiently parallelized first. Specifically, the GPU algorithm for the 1D EDT, which uses CUDA (Compute Unified Device Architecture) binary functions, such as ballot(), ffs(), clz(), and shfl(), runs in <inline-formula> <tex-math notation="LaTeX">$O(log_{32}n)$ </tex-math></inline-formula> time and performs <inline-formula> <tex-math notation="LaTeX">$O(n)$ </tex-math></inline-formula> work. Using the 1D EDT as a fundamental operation, the fully-parallelized work-time optimal 2D EDT algorithm is designed. This algorithm consists of three steps. Step 1 of the algorithm runs in <inline-formula> <tex-math notation="LaTeX">$O(log_{32}n)$ </tex-math></inline-formula> time and performs <inline-formula> <tex-math notation="LaTeX">$O(N)$ </tex-math></inline-formula> (<inline-formula> <tex-math notation="LaTeX">$N = n^{2}$ </tex-math></inline-formula>) of total work on GPU. Step 2 performs <inline-formula> <tex-math notation="LaTeX">$O(N)$ </tex-math></inline-formula> of total work and has an expected time complexity of <inline-formula> <tex-math notation="LaTeX">$O(logn)$ </tex-math></inline-formula> on GPU. Step 3 runs in <inline-formula> <tex-math notation="LaTeX">$O(log_{32}n)$ </tex-math></inline-formula> time and performs <inline-formula> <tex-math notation="LaTeX">$O(N)$ </tex-math></inline-formula> of total work on GPU. As far as we know, this algorithm is the first fully-parallelized and realized work-time optimal algorithm for GPUs. The experimental results show that this algorithm outperforms the prior state-of-the-art GPU algorithms.
SIOP-E-BTG and GPOH Guidelines for Diagnosis and Treatment of Children and Adolescents with Low Grade Glioma

Abstract Low grade gliomas (LGGs) constitute the largest, yet clinically and (molecular-) histologically heterogeneous group of pediatric brain tumors of WHO grades I and II occurring throughout all pediatric age groups and at all central nervous system (CNS) sites. The tumors are characterized by a slow growth rate and may show periods of growth arrest. Around 40% of all LGG patients can be cured by complete neurosurgical resection and are followed by close observation. In case of relapse, second resection often is possible. Following incomplete resection observation is recommended, as long as there is no radiologic tumor growth and the patient does not suffer from significant, tumor-related symptoms. This also applies to patients with a diagnosis of LGG on the basis of radiological criteria. By contrast, clinical worsening and / or radiologic progression are an indication to treatment with either chemo- or radiotherapy. Overall survival is around 90%, and many patients survive with residual tumor, i. e. they suffer from chronic disease. All patients need comprehensive neuro-oncological care, the principles and details of which are summarized in the current guidelines. These represent standard of care for diagnostic work-up (including neuroimaging and neuropathology), and for therapeutic decisions (including the indications to non-surgical treatment) as well as concepts for neurosurgical intervention, chemotherapy and radiotherapy as well as surveillance and rehabilitation. The current treatment algorithm was compiled by members of the LGG working group of the SIOP-E brain tumor group (SIOP-E-BTG) and is based upon the results of previous European LGG studies and international reports.
Predicting Operational Tolerance in Pediatric Living-Donor Liver Transplantation by Absence of HLA Antibodies

Background The role of anti–human leukocyte antigen (HLA) antibodies in operational tolerance (OT) after pediatric living-donor liver transplantation (LDLT) remains inconclusive. We investigated whether the presence of HLA antibodies impeded the development of OT. Methods We retrospectively examined the prevalence of anti-HLA antibodies in pediatric LDLT recipients before transplantation and at 3 weeks after transplantation and analyzed the significance of those antibodies in relation to later OT. Forty pediatric LDLTs were performed between April 1996 and December 2000 and followed up through July 2011, with sera available for measurement of HLA antibodies. Seventeen patients achieved OT (mean follow-up, 4571.9±544.7 days) and 23 patients did not achieve OT (mean follow-up, 4532.0±425.4 days). Protocol liver biopsy was done for 14 OT patients and 16 non-OT patients. Their sera were tested for anti-HLA class I and II antibodies using the LABScreen single antigen beads test, in which a 1000 mean fluorescence value was considered positive. Results The prevalence of antibodies after transplantation in non-OT patients was higher than in OT patients (95.2% vs. 73.3%; P<0.001). The highest mean fluorescence intensity of antibodies was significantly higher in non-OT patients than in OT patients. The prevalence of HLA-B, HLA-C, HLA-DQ, and HLA-DR antibodies was significantly higher in non-OT patients than in OT patients. The highest mean fluorescence intensity of HLA-A, HLA-B, and HLA-DQ observed in non-OT patients was significantly higher than those in OT patients. Conclusions In our study, posttransplantation HLA antibodies were associated with the future absence of OT. A prospective study with more patients is necessary to confirm the predictive value of HLA antibodies for OT.
Risk Factors and Prevalence of Abdominal Obesity among Upper-Secondary Students

Inadequate eating habits, as well as a low level of physical activity, influence adipose tissue deposition. The aim of the study was to assess the prevalence of central obesity in upper-secondary students and to determine the factors related to its occurrence. The survey included 309 participants, aged 16 to 18 years from Krakow (Poland). Anthropometric measurements were taken during the periodic assessment of students’ health status. An anonymous questionnaire was used to assess the nutritional and non-nutritional risk factors of participants. According to different methods of measurement, abdominal obesity (AO) was observed in 15.5% (WC—waist circumference), 10.7% (WHtR—waist to height ratio) or 21.7% (WHR—waist to hip ratio) participants. Abdominal obesity (WC) was significantly associated with family history of excess body weight and higher economic status of the family. The risk of AO (WC) was significantly lower among adolescents who declared higher physical activity. Boys who eat first breakfasts have lower AO risk according to WHtR interpretation. Abdominal obesity in gender group was related to the self-esteem of one’s own appearance according to WHtR and WC. Abdominal obesity was associated with the family environment and modifiable lifestyle factors and was dependent on gender.
Investigations on the effect of voltage harmonics on leakage current for condition monitoring in insulators

Leakage current pattern and its harmonic content are widely known to be excellent monitoring indices for condition assessment of overhead line insulators. Whenever there is a change in the contamination severity on the insulator surface, a corresponding change in the leakage current is observed. Traditionally, it has been assumed that the changes in leakage current pattern are entirely due to the changes in surface condition of insulators. However, in real-time online monitoring, the system voltage and its harmonic content will also have a certain effect on the leakage current pattern. Changes in the harmonic content of system voltage may also produce changes in the leakage current pattern. This may lead to incorrect interpretation of the obtained results where systems are prone to harmonic distortions. In such cases, there is no way of knowing whether the change in leakage current pattern is entirely due to changes in surface condition of insulators or on account of harmonics in the applied voltage. Keeping this in mind, this work investigates for the first time the effect of presence of harmonics in voltage waveform on the leakage current pattern in overhead insulators. The purpose of this paper is to present the preliminary results on the degree of influence of voltage harmonics on the leakage current pattern, and demonstrate the importance of more detailed research on the topic.
Optimizing Selection and Mating in Genomic Selection with a Look-Ahead Approach: An Operations Research Framework

New genotyping technologies have made large amounts of genotypic data available for plant breeders to use in their efforts to accelerate the rate of genetic gain. Genomic selection (GS) techniques allow breeders to use genotypic data to identify and select, for example, plants predicted to exhibit drought tolerance, thereby saving expensive and limited field-testing resources relative to phenotyping all plants within a population. A major limitation of existing GS approaches is the trade-off between short-term genetic gain and long-term potential. Some approaches focus on achieving short-term genetic gain at the cost of reduced genetic diversity necessary for long-term gains. In contrast, others compromise short-term progress to preserve long-term potential without consideration of the time and resources required to achieve it. Our contribution is to define a new “look-ahead” metric for assessing selection decisions, which evaluates the probability of achieving high genetic gains by a specific time with limited resources. Moreover, we propose a heuristic algorithm to identify optimal selection decisions that maximize the look-ahead metric. Simulation results demonstrate that look-ahead selection outperforms other published selection methods.