Miracle-dz/UniFAR-FTUs huggingface dataset:
Attacking Profiles of the Best Ranked Teams From Elite Futsal Leagues

This study aimed to (i) explore the discriminatory power of the task-related variables and the context in establishing differences in the elite futsal leagues of Portugal, Spain, and Russia and (ii) understand how these variables vary according to the match outcome. Methodological issues concerning efficiency (goals and shots), offensive organisation (positional attack, counterattack, set pieces, or 5vs4+Goalkeeper), 1st goal scored during matches (home or away team), match type (balanced or unbalanced), and match outcome (winner, loser, or drawer) were discussed. Archival data were obtained from the 2017–2018 season of Portuguese, Spanish, and Russian professional futsal leagues for all play-off matches. Crosstabs analysis was conducted to establish the significance relationship between the elite futsal leagues and the situational variables. Afterward, discriminant analysis was used to identify the task-related variables that maximise mean differences between different league teams for defining offensive profile, and the variations found when the condition of the winner, loser, or drawer is taken into account. The results allowed to understand that the Portuguese and Russian teams used the positional attacks more, and less the counterattacks and set pieces than the Spaniards, who present a more balanced offensive profile. Overall, winners were better discriminated by goals scored, whereas 5vs4+Goalkeeper strategy discriminated loser teams. Coaches should be aware of these different offensive profiles in order to increase control over the match planning and decrease predictability against opposing teams.
Activation of Immune Genes in Leafhoppers by Phytoplasmas and Symbiotic Bacteria

Insect immunity is a crucial process in interactions between host and microorganisms and the presence of pathogenic, commensal, or beneficial bacteria may result in different immune responses. In Hemiptera vectors of phytoplasmas, infected insects are amenable to carrying high loads of phytopathogens, besides hosting other bacterial affiliates, which have evolved different strategies to be retained; adaptation to host response and immunomodulation are key aspects of insect-symbiont interactions. Most of the analyses published to date has investigated insect immune response to pathogens, whereas few studies have focused on the role of host immunity in microbiota homeostasis and vectorial capacity. Here the expression of immune genes in the leafhopper vector of phytoplasmas Euscelidius variegatus was investigated following exposure to Asaia symbiotic bacteria, previously demonstrated to affect phytoplasma acquisition by leafhoppers. The expression of four genes related to major components of immunity was measured, i.e., defensin, phenoloxidase, kazal type 1 serine protease inhibitor and Raf, a component of the Ras/Raf pathway. The response was separately tested in whole insects, midguts and cultured hemocytes. Healthy individuals were assessed along with specimens undergoing early- and late-stage phytoplasma infection. In addition, the adhesion grade of Asaia strains was examined to assess whether symbionts could establish a physical barrier against phytoplasma colonization. Our results revealed a specific activation of Raf in midguts after double infection by Asaia and flavescence dorée phytoplasma. Increased expression was observed already in early stages of phytoplasma colonization. Gut-specific localization and timing of Raf activation are consistent with the role played by Asaia in limiting phytoplasma acquisition by E. variegatus, supporting the involvement of this gene in the anti-pathogen activity. However, limited attachment capability was found for Asaia under in vitro experimental conditions, suggesting a minor contribution of physical phytoplasma exclusion from the vector gut wall. By providing evidence of immune modulation played by Asaia, these results contribute to elucidating the molecular mechanisms regulating interference with phytoplasma infection in E. variegatus. The involvement of Raf suggests that in the presence of reduced immunity (reported in Hemipterans), immune genes can be differently regulated and recruited to play additional functions, generally played by genes lost by hemipterans.
Treponema pallidum Induces the Secretion of HDVSMC Inflammatory Cytokines to Promote the Migration and Adhesion of THP-1 Cells

The pathological features of syphilis, a disease caused by Treponema pallidum (T. pallidum), are characterized by vascular involvement with endarteritis and periarteritis. Little is known about the interactions of infiltrating immunocytes with human dermal vascular smooth muscle cells (HDVSMCs) in arterioles during the immunopathogenesis of syphilis. In the present study, we demonstrated that stimulation of HDVSMCs with T. pallidum resulted in the upregulated gene transcription and protein expression of interleukin (IL)-6, monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule-1 (ICAM-1) in a dose- and time-dependent manner. Moreover, the migration and adhesion of THP-1 cells to HDVSMCs were significantly suppressed by anti-MCP-1 and anti-ICAM-1 neutralizing antibodies, respectively. Further studies revealed that T. pallidum activated the NF-κB signaling pathway in HDVSMCs. Inhibition of NF-κB suppressed T. pallidum-induced IL-6, MCP-1, and ICAM-1 expression. In addition, the migration and adhesion of THP-1 cells to T. pallidum-treated HDVSMCs were significantly decreased by pretreatment with an NF-κB inhibitor. These findings demonstrate that T. pallidum induces the production of IL-6, MCP-1, and ICAM-1 in HDVSMCs and promotes the adherence and migration of THP-1 cells to HDVSMCs through the NF-κB signaling pathway, which may provide new insight into the pathogenesis of T. pallidum infection.
Not Just a Pathogen? Description of a Plant-Beneficial Pseudomonas syringae Strain

Plants develop in a microbe-rich environment and must interact with a plethora of microorganisms, both pathogenic and beneficial. Indeed, such is the case of Pseudomonas, and its model organisms P. fluorescens and P. syringae, a bacterial genus that has received particular attention because of its beneficial effect on plants and its pathogenic strains. The present study aims to compare plant-beneficial and pathogenic strains belonging to the P. syringae species to get new insights into the distinction between the two types of plant–microbe interactions. In assays carried out under greenhouse conditions, P. syringae pv. syringae strain 260-02 was shown to promote plant-growth and to exert biocontrol of P. syringae pv. tomato strain DC3000, against the Botrytis cinerea fungus and the Cymbidium Ringspot Virus. This P. syringae strain also had a distinct volatile emission profile, as well as a different plant-colonization pattern, visualized by confocal microscopy and gfp labeled strains, compared to strain DC3000. Despite the different behavior, the P. syringae strain 260-02 showed great similarity to pathogenic strains at a genomic level. However, genome analyses highlighted a few differences that form the basis for the following hypotheses regarding strain 260-02. P. syringae strain 260-02: (i) possesses non-functional virulence genes, like the mangotoxin-producing operon Mbo; (ii) has different regulation pathways, suggested by the difference in the autoinducer system and the lack of a virulence activator gene; (iii) has genes encoding DNA methylases different from those found in other P. syringae strains, suggested by the presence of horizontal-gene-transfer-obtained methylases that could affect gene expression.
Potential role of estradiol in ovariectomy-induced derangement of renal endocrine functions

Abstract Menopause is an important physiological event associated with structural and functional changes in the kidneys. An animal model of bilateral ovariectomy was used to study the effects of estrogen depletion, replacement and antiestrogen on renal structure and endocrine function. Sixty female rats were divided into six groups; group I was the control group, the remaining five groups underwent ovariectomy: group II received no treatment. The other groups received estradiol in group III, tamoxifen in group IV, estradiol followed by tamoxifen in group V and tamoxifen followed by estradiol in group VI. Serum creatinine, blood urea nitrogen, and endocrine functions of kidney were measured. Tissue samples were examined both microscopically for beta estrogen receptors and ultrastructurally for cell changes. Groups II, IV & VI showed a significant increase in creatinine, blood urea nitrogen, renal malondialdehyde, renal erythropoietin, plasma renin and plasma prostaglandin E2 and a significant decrease in renal antioxidants and serum vitamin D3. Groups III &V had a significant decrease in creatinine, blood urea nitrogen, renal malondialdehyde and renal erythropoietin with an increase in renal antioxidants, plasma prostaglandin E2 and serum vitamin D3. Histopathological and ultrastructural examinations revealed atrophic tubular changes in group II. The changes were less marked in groups III &V and more extensive in groups IV & VI. Estrogen receptor beta staining showed progressively increased expression in the absence of estrogen. Structural and most endocrine functions of the kidney were significantly affected by estradiol deficiency. Estradiol replacement exhibited a protective effect on renal tissue and endocrine functions.
Cohort profile: the West Sweden Asthma Study (WSAS): a multidisciplinary population-based longitudinal study of asthma, allergy and respiratory conditions in adults

Purpose The West Sweden Asthma Study (WSAS) is a population-representative longitudinal study established to: (1) generate data on prevalence trends, incidence and remission of asthma, allergy and respiratory conditions, (2) elucidate on the risk and prognostic factors associated with these diseases, (3) characterise clinically relevant phenotypes of these diseases and (4) catalyse relevant mechanistic, genomic, genetic and translational investigations. Participants WSAS comprised of randomly selected individuals aged 16 to 75 years who are followed up longitudinally. The first stage involved a questionnaire survey (>42 000 participants) and was undertaken in 2008 and 2016. A random sample (about 8000) of participants in the initial survey undergoes extensive clinical investigations every 8 to 10 years (first investigations in 2009 to 2012, second wave currently ongoing). Measurements undertaken at the clinical investigations involve structured interviews, self-completed questionnaire on personality traits, physical measurements and extensive biological samples. Findings to date Some of our key findings have shown a 54% increase in the use of asthma medications between the 1990s and 2000s, primarily driven by a five-fold increase in the use of inhaled corticosteroids. About 36% of asthmatics expressed at least one sign of severe asthma indicator, with differential lung performance, inflammation and allergic sensitisation among asthmatics with different signs of severe asthma. Multi-symptom asthmatics were at greater risk of having indicators of severe asthma. In all adults, being raised on a farm was associated with a decreased risk of allergic sensitisation, rhinitis and eczema, but not asthma. However, among adolescents (ie, those 16 to 20 years of age), being raised on a farm decreased the risk of asthma. Personality traits were associated with both beliefs of asthma medication and adherence to treatment. Future plans Follow-up of the cohort is being undertaken every 8 to 10 years. The repeated clinical examinations will take place in 2019 to 2022. The cohort data are currently being linked to routine Swedish healthcare registers for a continuous follow-up. Mechanistic, genomic, genetic and translational investigations are ongoing.
Effects of stimulation frequency and stimulation waveform on steady-state visual evoked potentials using a computer monitor

Objective. A visual stimulator plays a vital part in brain–computer interfaces (BCIs) based on steady-state visual evoked potential (SSVEP). The properties of visual stimulation, such as frequency, color, and waveform, will influence SSVEP-based BCI performance to some extent. Recently, the computer monitor serves as a visual stimulator that is widespread in SSVEP-based BCIs because of its great flexibility in generating visual stimuli. However, stimulation properties based on a computer monitor have received very little attention. For a better comprehension of SSVEPs, this study explored the stimulation effects of waveforms and frequencies, when evoking SSVEPs through a computer monitor. Approach. This study utilized the approximation methods to realize sine- and square-wave temporal modulations at 18 stimulation frequencies ranging from 6 to 40 Hz on a conventional 120 Hz LCD screen. We collected electroencephalogram (EEG) datasets from 12 healthy subjects and compared the signal-to-noise ratios (SNRs), amplitudes, and topographic mapping of SSVEPs evoked by these two temporal modulation flickers (sine- and square-wave). In addition, a BCI experiment with two nine-target BCIs (i.e. low-frequency BCI and high-frequency BCI) was implemented to compare the two stimulation waveforms in terms of BCI performance. Main results. For both sine- and square-wave stimulation conditions, strong SSVEPs over the occipital area were observed for each stimulation frequency. SSVEP amplitudes at the stimulation frequency exhibited a global peak in the low-frequency band. The second harmonic SSVEP frequency-response functions showed the largest amplitude at 6 Hz and fell sharply for higher frequencies. In the BCI experiment, the classification performance of the square-wave stimuli was notably higher than that of the sine-wave stimuli when using shorter data lengths. Significance. These results suggested that the square-wave flicker was more efficient at implementing high-speed BCIs based on SSVEP when using a computer monitor as a visual stimulator.
Breathing Rate Estimation Using Kalman Smoother With Electrocardiogram and Photoplethysmogram

Objective: The objective of this paper is to obtain accurate estimation of breathing rate (BR), using only the electrocardiogram (ECG) or the photoplethysmogram (PPG) signals, to avoid wearing cumbersome and uncomfortable sensors for direct measurements. Methods: Several respiration waveforms are derived from ECG or PPG signals based on amplitude, frequency, and baseline wander modulations. It is, however, difficult to determine their optimal combination for BR estimation due to the noise and patient specificity. We first propose to quantify the quality of modulation waveforms using respiratory quality indices (RQIs). We then present two methods: the first automatically selects the modulation signal with highest RQI for BR estimation, and the second tracks the respiration signal using the Kalman smoother to fuse modulation signals with highest RQI. Results: These two methods are evaluated on two independent datasets, one benchmark database (DB) with immobilized patients recordings and the second with those performing daily activities. Our results outperform existing methods in the literature in both the cases. Conclusion: Experimental results show that the RQIs coupled with a fusion algorithm increases the accuracy for BR estimations in dealing with derived modulation signals. Significance: This work describes a robust Kalman Smoother method applicable in multiple clinical contexts to improve breathing rate estimation from data fusion.
Novel Approaches Toward Area- and Energy-Efficient Embedded Memories

Keywords: embedded memories ; VLSI systems ; SoC ; ASIC ; CMOS ; SRAM ; eDRAM ; standard-cell based memory ; dynamic storage cells ; voltage scaling ; near-threshold operation ; sub-threshold operation ; ultra-low power ; reliability ; non-volatile memory ; ReRAM ; OxRAM ; gain-cells ; gain-cell based eDRAM (GC-eDRAM) ; retention time improvement ; refresh power reduction ; body biasing ; replica techniques ; technology scaling ; multilevel gain-cell These Ecole polytechnique federale de Lausanne EPFL, n° 6074 (2014)Programme doctoral Microsystemes et MicroelectroniqueFaculte des sciences et techniques de l'ingenieurInstitut de genie electrique et electronique Laboratoire de circuits pour telecommunicationsJury: Prof. D. Atienza Alonso (president), Prof. A.P. Burg, Prof. Y. Leblebici (directeurs), Prof. C. Enz, Prof. A. Fish, Prof. J. Rodrigues (rapporteurs) Public defense: 2014-2-7 Reference doi:10.5075/epfl-thesis-6074Print copy in library catalog Record created on 2014-01-29, modified on 2017-05-10
Asynchronous and distributed multi-criteria decision making using a web-based group support system

A detailed model for designing a Web-based Multi-Criteria Group Support System (MCGSS) is presented. The model is based on the Analytic Hierarchy Process (AHP) and uses the intensity of preferences of group members rather than simple voting procedures. This approach offers several advantages over simple voting mechanisms, including a much richer picture of both individual and group positions and more equitable decision-making. A prototype system, with a user-friendly graphical user interface (GUI), has been developed and used to analyze an experimental group decision process over the Internet. This permits a wider range of users, including those with limited typing skills, asynchronous communication across many time zones, and a larger number of participants than conventional systems. An agenda for further research is outlined.
Demonstration of Learned Helplessness with Fuzzy Reinforcement Learning

This paper demonstrates a kind of learned helplessness in human being that is appeared in Fuzzy Reinforcement Learning (FRL) algorithm. At the beginning of learning, when an agent continuously performs actions that cause sequential punishments, afterwards it does not usually behave well and often selects actions that evoke punishments. This faulty learning is similar to what is called learned helplessness in social sciences. Here, this problem is demonstrated in training an agent by FRL algorithm. By analyzing this problem, a new reinforcement function for prevention is presented.
Factors Associated with Adherence to Transdermal Nicotine Patches within a Smoking Cessation Effectiveness Trial.

Background Adherence to transdermal nicotine patches, one of the most popular and effective treatment for nicotine dependence, remains very low and is a strong predictor of cessation rates. This study examined individual factors related to adherence as well as differences over time between adherent (≥ 80% of daily patch use) and non-adherent participants (< 80% of daily patch use). Methods We analyzed data from 440 participants who received 8 weeks of 21mg transdermal nicotine and 4 behavioral counseling sessions within an effectiveness trial that examined the effects of long-term treatment. Multiple logistical regression assessed baseline variables associated with patch adherence and generalized estimating equations (GEE) were used to evaluate changes in craving and withdrawal, depressive and anxiety symptoms, substitute and complementary reinforcers, and side effects between participants who were or were not adherent. Results In a logistic regression model, being female, living with a child or children, and higher self-reported anxiety symptoms were predictive of lower patch adherence (p < .05). In the GEE analysis, adherence was significantly associated with: a greater reduction in craving, a greater engagement in substitute reinforcers, and a greater decrease in complementary reinforcers over time (p < .05). Conclusions Difficulties adhering to transdermal nicotine patches may be related to psychiatric comorbidity, difficulty managing nicotine craving, and challenges with engaging in substitute reinforcers and reducing exposure to complementary reinforcers. These constructs may serve as targets for interventions designed to increase treatment adherence.
Software process modeling at SEI

A discussion is presented of a software process modeling case study. The four primary objectives of software process modeling are summarized. Thirteen substantive requirements for a software modeling approach are identified. The author has developed a model of this process utilizing a commercially available automated system called STATEMATE. Although this system was originally developed to aid in specifying and designing real-time reactive systems software, successful experiences indicate that it is well suited for modeling software processes. STATEMATE offers a representation formalism that is highly visual, yet formally defined. <<ETX>>
In-Vivo Quantitative Image Analysis of Age-Related Morphological Changes of C. elegans Neurons Reveals a Correlation between Neurite Bending and Novel Neurite Outgrowths

Abstract The aging of the human brain in the absence of diseases is accompanied by subtle changes of neuronal morphology, such as dendrite restructuring, neuronal sprouting, and synaptic deteriorations, rather than neurodegeneration or gross deterioration. Similarly, the nervous system of Caenorhabditis elegans does not show neurodegeneration or gross deterioration during normal aging, but displays subtle alterations in neuronal morphology. The occurrence of these age-dependent abnormalities is stochastic and dynamic, which poses a major challenge to fully capture them for quantitative comparison. Here, we developed a semi-automated pipeline for quantitative image analysis of these features during aging. We employed and evaluated this pipeline herein to reproduce findings from previous studies using visual inspection of neuronal morphology. Importantly, our approach can also quantify additional features, such as soma volume, the length of neurite outgrowths, and their location along the aged neuron. We found that, during aging, the soma of neurons decreases in volume, whereas the number and length of neurite outgrowths from the soma both increase. Long-lived animals showed less decrease in soma volume, fewer and shorter neurite outgrowths, and protection against abnormal sharp bends preferentially localized at the distal part of the dendrites during aging. We found a correlation of sharp bends with neurite outgrowth, suggesting the hypothesis that sharp bends might proceed neurite outgrowths. Thus, our semi-automated pipeline can help researchers to obtain and analyze quantitative datasets of this stochastic process for comparison across genotypes and to identify correlations to facilitate the generation of novel hypothesis.
H/sup infinity / control of a twin lift helicopter system

Two H/sup infinity / controller designs are presented for a twin lift helicopter system (TLHS). The TLHS configuration consists of two US-60A Sikorsky Blackhawk helicopters jointly lifting a heavy payload. The first design presented considers the case in which the tethers connecting each helicopter to the load are equal in length, and the second considers the case in which the lengths are unequal. Both designs are based on a seven-degree-of-freedom model linearized about hover. The primary objective of each controller is to minimize the control action and pitching motion required to stabilize the helicopters as they perform elementary maneuvers. A simulation of a typical TLHS command scenario is used to evaluate the stability robustness characteristics of the resulting two feedback systems with respect to structured parametric uncertainty. <<ETX>>
Culturable endophytic bacteria of Camellia species endowed with plant growth promoting characteristics

Tea (Camellia sinensis (L.) O. Kuntze) is an economically important caffeine‐containing beverage crop with massive plantation in the Northeast corner of the agroclimatic belt of India. The main aim of the work was to isolate, identify and characterize the native plant growth promoting endophytes associated with tea for future microbe based bioformulation.