Miracle-dz/UniFAR-FTUs huggingface dataset:
A case of prohormone convertase deficiency diagnosed with type 2 diabetes

Prohormone convertase 1/3, encoded by the proprotein convertase subtilisin/kexin type 1 gene, is essential for processing prohormones; therefore, its deficiency is characterized by a deficiency of variable levels in all hormone systems. Although a case of postprandial hypoglycemia has been previously reported in the literature, prohormone convertase insufficiency with type 2 diabetes mellitus has not yet been reported. Our case, a 14-year-old girl, was referred due to excess weight gain. She was diagnosed as having type 2 diabetes mellitus based on laboratory test results. Prohormone convertase deficiency was considered due to the history of resistant diarrhea during the infancy period and her rapid weight gain. Proinsulin level was measured as >700 pmol/L(3.60–22) during diagnosis. In genetic analysis, a c.685G> T(p.V229F) homozygous mutation in the PCSK1 gene was detected and this has not been reported in relation to this disorder. In conclusion, patients with recurrent resistant diarrhea during infancy followed by rapid weight gain need to be evaluated with the diagnosis of prohormone convertase deficiency.
Comparative Study of Cyclic Fatigue Resistance of Protaper Gold, OneShape, and TF Files

Aim: The purpose of this study was to compare the resistance to cyclic fatigue of three nickel-titanium (NiTi) endodontic instruments from Protaper Gold (PTG), OneShape (OS), and Twisted files (TF). Methodology: A total of 45 nickel-titanium instruments were tested and divided into 3 experimental groups (n = 15): group 1, Protaper Gold (F2 25/.08); group 2, OneShape (25/.06) file; and group 3, Twisted file (25/.06). The testing device was specially designed for this experiment. The time and cycles to failure were calculated. The data were compared for differences by using 2-way analysis of variance (p < 0.05). Results: Statistical analysis revealed that PTG showed the statistically significantly highest mean cyclic fatigue value, while TF showed statistically significantly lower mean cyclic fatigue value. OS system showed the statistically significantly lowest mean cyclic fatigue value. Conclusions: ProTaper Gold files demonstrated significantly higher cyclic fatigue resistance than OneShape and Twisted files, while OneShape files revealed the lowest cyclic fatigue resistance. The enhanced alloy properties of ProTaper Gold may be the main reason for this difference.
Program Eliminasi Lymphatic Filariasis di Indonesia

Filariasis has been a public health problem in Indonesia for a long time and WHO has established this disease as a neglected disease which is a public health problem in the world, therefore a global filariasis elimination program that must be achieved in 2020. This article compiles some literature for writing references related to the development of global filariasis elimination and the progress of filariasis elimination in Indonesia particularly. Filariasis elimination program in Indonesia has been running at least 26 districts that have stopped implementing mass drug administration (MDA) from 239 endemic filariasisdistricts. The remaining districts are expected to have implemented MDAstart from 2015 so that the year 2020 is completed and verified also given predicates of filariasis elimination according to global target of filariasis elimination. Management-based and community-based research is important to determine the best model of elimination. There are still many challenges in increasing coverage, so that continuing education efforts on filariasis and the importance of treatment will motivate communities to play an active role in achieving maximum coverage targets, and national filariasis elimination targets can be achieved by 2020.
Tribute and a Perspective: Reto Jörg Strasser: An innovator, a wonderful friend and “Professor of the World"

DOI:-https://doi.org/10.32381/JPSR.2019. 35.02. 1 After presenting a very brief insight into the life of Reto Jörg Strasser, we provide here first a glimpse of his joint research with Govindjee, in the 1990s, done at the Bioenergetics laboratory, University of Geneva, Switzerland. They both had the most wonderful time there; Reto’s collaborative spirit was superb. The two have interacted with each other since then and have continued even after their retirement(s). This is followed by a brief description of this interaction as well as a glimpse of Reto’s life and career. Then, Alaka Srivastava and Sandra Stirbet, who have worked with Reto for around eight years, in Geneva, Switzerland, Vineet Soni, who did a post-doc with Reto, and Neera Bhalla Sarin, who had worked with Reto in New Delhi, India, provide their tributes to Reto by remembering their time with him. We all honor Reto Jörg Strasser on his 75th birthday that was in December, 2018. Some of us expect our collaboration to continue in the future. To all of us, Reto is an innovator of the highest order, and a wonderful friend. He is dedicated to his family, his friends, his students and all his collaborators–worldwide. He is indeed a special person; we have included here several photographs to document our camaraderie with him.
Pelatihan Seni bagi Orangtua Siswa PAUD Jl.UNPAR II No. 10, Sukawarna, Cibogo, Bandung

Early Childhood Education Program (PAUD) is an informal goverment education program for children which is mostly held to answer the need of lower economy community. These community consist of family who are mainly dependent to the fathers as the main source of income. The informal school give education to children of the age of 3-5 for 2 hours duration per day. The mothers have the habit of taking their children to school and waited until finished. Hence this is potential to give these mothers additional art and craft skill , hence in the future after they could produce sellable craft to help gaining additional income for the family.
Stereotactic radiotherapy for choroidal melanoma: analysis of eye movement during treatment

This study aims to analyse the eye’s movement during radiotherapy treatment for choroidal melanoma, as well as the methodology used in the repositioning of the patient between treatments sessions. For this purpose, the procedures used by the hospital staff were analysed on site and videos were recorded during the treatments. The methodology for the fixation of the eye is correct in its objective. However, the repositioning needs improvements in its reproducibility. It is recommended the study to fix the eye by the healthy eye and the feasibility study for the development of a software that assists in patient repositioning.
Interlimb Asymmetries: Understanding How to Calculate Differences From Bilateral and Unilateral Tests

ABSTRACT INTERLIMB ASYMMETRIES HAVE BEEN A POPULAR TOPIC OF INVESTIGATION IN THE STRENGTH AND CONDITIONING LITERATURE. RECENTLY, NUMEROUS EQUATIONS HAVE BEEN HIGHLIGHTED THAT CAN QUANTIFY THESE BETWEEN-LIMB DIFFERENCES. HOWEVER, NO DISTINCTION WAS PROVIDED ON WHETHER THEIR USE WAS APPLICABLE TO BOTH BILATERAL AND UNILATERAL TESTS. THIS ARTICLE PROVIDES A FRAMEWORK FOR SELECTING THE MOST APPROPRIATE ASYMMETRY EQUATION BASED ON THE SELECTED TEST METHOD, ENSURING ACCURATE CALCULATION AND INTERPRETATION. IN ADDITION, CONSIDERATIONS FOR DATA ANALYSIS HAVE ALSO BEEN INCLUDED AS A GUIDE FOR PRACTITIONERS ON THE RELEVANCE OF MONITORING INTERLIMB DIFFERENCES LONGITUDINALLY.
Derivatives Growth Confirming Financial Sustainability: Anecdotes from Derivatives in CBOE & NSE

Purpose: A country’s growth can better be measured in terms of financial indicators; derivatives is one of them. It is one of the evolving instruments to hedge risk and offer information about market and thereby economy. With this background, the objective of the paper is to study and compare the Indian options with European options.Research Methodology: The data has been used for Nifty and CBOE exchange for 2018-19. To analyse the determinants, options mispricing in B-S model is explained. The linear Granger causality test has been used to identify potential variable to determine implied volatility smile.Findings: The study finds difference in volatility in both the markets. It is advocated that European market is more mature than nascent Indian market.Value: Derivatives being the instruments of hedging needs to be developed in India. In this regard the paper study the relationship between implied volatility and money-ness has been analysed and compared in both the markets. The determinants affecting volatility has been identified.
The Association between Mental Workload and Work-related Musculoskeletal Disorders in Workers of Ahvaz Kavian Steel Company

Background: One of the most important problems in modern industries is the high mental workload which can affect the health and hygiene of workers in these industries. This study was carried out to investigate the association between mental workload and workrelated musculoskeletal disorders (WMSDs) in a case study among workers of Ahvaz Kavian Steel Company, Ahvaz, Iran, in 2016. Methods: In this descriptive cross-sectional study, 240 workers of Ahvaz Kavian Steel Company participated. Data collection tools were the Nordic Musculoskeletal Disorders Questionnaire (NMQ) and NASA-TLX mental workload questionnaire, filled out through interviewing participants in the work place. Data were analyzed by using independentsamples t-test and chi-square in SPSS19. Results: During the last 12 months, 75.8% of workers experienced musculoskeletal disorder symptoms. "Physical demand" (P=0.002) and "Effort" (P=0.015) from the NASA-TLX questionnaire and shift work, among demographic features, (P=0.025) were significantly associated with MSDs prevalence in these workers. Conclusion: Musculoskeletal disorders had a high prevalence in workers of Ahvaz Kavian Steel Company. Because of the significant relation between of some dimensions of the mental work load index and demographic characteristics with musculoskeletal disorders; creating proper working conditions, utilizing ergonomic based designed implements and providing more staff training programs, can help prevent musculoskeletal disorders.
Survey of use mobile augmented reality for teaching materials

This study discusses the review of the literature focuses on the use of Augmented Reality (AR) as a teaching material. Authors conducted a review 20 articles which were published from 2008 to 2018. Design studies also found a variety of experiments such as data, analysis, action research, surveys, mixed methods, and Research and Development. This review found that the use of AR as a teaching material in learning shows that the AR is able to improve your skills, understanding, motivation, response, and the results of student learning of the content and media used.
Online examination for takaful basic examination – a license to practice certificate: a Malaysian case

The purpose of this study is to examine the extent of effectiveness of the online examination using electronic learning management system (e-LMS) services in the Malaysian Takaful sector for Takaful Basic Examination (TBE). TBE is conducted through online examination which is a web-based examination system (ES). The TBE is an entry qualification for all those who intend to become registered takaful agents in the financial services industry promoting takaful products and services. The term Takaful refers to the concept of Islamic insurance based on mutual cooperation, where both risks and funds are shared between the insured and insurer. TBE is a mandatory license-to-practice qualification to enhance the competency and professionalism of takaful agents. It is also an induction for individuals who intend to pursue a career in Takaful. The study also aims to address issues concerning quality of services by focusing on the following: ease of use, information security and reliability and its role in influencing customer adoption of electronic services, as well as the mechanisms of monitoring and control over these services. The research employed the analytic and descriptive methodology, by collecting secondary data on candidates sitting for the examination. This was then compared to the passing rate from the year 2012 until 2016. The findings show that online examinations have succeeded in attaining significant customer satisfaction by improving electronic services, facilitating electronic transactions, improving processing performance and enhancing the specifications of electronic services. In addition, the Takaful institutions have achieved effective communication with their customers as well as speeding up of applications. However, there is an absence of awareness and guidance for candidates about the e-examination system. The results of this research led to some recommendations to improve the electronic services provided by Takaful institutions in order to enhance customer and institution’s satisfaction. (Abstract by authors)
Biomarkers for eligibility and surrogate endpoints in heart failure trials

6 List of original papers 7 List of abbreviations 8 Introduction 9 Global burden 9 Definition 9 Etiology, risk factors and clinical characteristics 10 Pathophysiology 10 HFrEF 10 HFpEF 10 Natriuretic peptides 10 1-year mortality and prognosticators 13 Treatments in HF 13 HFrEF 13 HFpEF 15 HFmrEF 15 ADHF 15 Failure of trials in HF 16 Aims 17 Patients and methods 18 Data source 18 Studies I, III and IV – the Swedish Heart Failure Registry (SwedeHF) 18 Studies II – the Karolinska-Rennes (KaRen) study 19 Study I 19 Aim 19 Patients 19 Endpoints 20 Study II 20 Aim 20 Patients 20 Endpoints 20 Statistics in Studies I-II 20 Study III 21 Aim 21 Patients 21 Endpoints 21 Statistics 22 Study IV 22 Aim 22 Patients 22 Endpoints 23 Statistics 23 Ethical considerations 23 Results 24 Study I 24 Study II 28 Study III 31 Study IV 38 Discussion 46 NPs as surrogate endpoints 46 Relationship between NT-proBNP levels and prognosis 46 Relationship between changes in NT-proBNP levels and prognosis 47 NT-proBNP for eligibility and enrichment in HF trials 47 Strengths and Limitations 48 Conclusions 50 Acknowledgements 51 References 52
Bakırköy dr. Sadi konuk eğitim araştırma hastanesi’nde hasta memnuniyeti ve etkileyen faktörlerin araştırılması

The analysis of patient satisfaction and related factors in Bakirköy Dr. Sadi Konuk Training and Research Hospital Objective: Determine the factors which affect patient satisfaction, associated with patient satisfactiondissatisfaction, uncover the demographıc characteristics of the inpatient and outpatient in İstanbul Bakırköy Dr Sadi Konuk Educatıon and Research Hospital. Material and Method: 1440 patients whom included in study admitted our hospital through 15 April 2010-2011, treated inpatient and outpatient. It was applied the outpatient and inpatient satisfaction questionnares, prepared by the Health Ministry about patients’ demograpic infortmation and
Characterizing Sleep-Wake Circadian Rhythm Consolidation in Early Childhood and Its Association with Motor Development Using Actigraphy

1. Child Health Advocacy Institute, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2. Department of Biostatistics, School of Public Health, Yale University, New Haven, CT, USA 3. School of Public Health, Shanghai Jiao Tong University, Shanghai, China 4. Department of Developmental and Behavioral Pediatrics, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China 5. Shanghai Jiao Tong University – Yale Joint Center for Biostatistics, Shanghai, China
Usefulness of the MMS and S5 for Assessing Medication Management Capacity for Clients Post-Stroke

Occupational therapists need a means to efficiently and accurately screen a client’s medication management capacity, especially for clients post-stroke. Most therapists are not aware of, nor do they utilize specific assessments for medication management capacity, partly due to lack of thorough assessments. The purpose of this study was to compare the scores of the ManageMed Screen (MMS), the Screening for Self-Medication Safety Post Stroke (S5), and the Montreal Assessment of Cognition (MoCA) on a population of rehabilitation clients post-stroke to evaluate consistency of scores and determine their usefulness in clinical practice. All screens were designed for use in occupational therapy; the MMS was validated for the general adult population, the S5 for clients post-stroke, and the MoCA is a cognitive screen used with adult clients with a variety of diagnoses including stroke. The MoCA was used to explore the potential relationship between cognition and medication management capacity. Study participants included five clients post-stroke and three occupational therapists. Clients were screened by the occupational therapists with the MMS, S5, and MoCA, and clinicians also participated in a focus group to assess their perceived usefulness of the screens. Results demonstrated that the MMS was consistent with the S5 in identifying the clients who performed the poorest. The MoCA has no consistent relationship with either the MMS or S5. Additionally, through a focus group, clinicians deemed both the MMS and S5 as useful, but felt the MMS was a more useful screen for their clinical practice in regards to efficient and practical use with clients post-stroke in a rehabilitation setting. MEDICATION MANAGEMENT CAPACITY POST-STROKE 3
Liberation On and Off Screen: Black Panther and Black Liberation Theory

2018’s Black Panther is arguably a revolutionary film. Revolutionary as it is the first blockbuster superhero film that features a predominately black cast, allowing people of color to see themselves represented in the film’s heroes. It also places women of color in the forefront of the action, breaking down common sexist tropes within the superhero genre. Beyond those issues of representation, Black Panther recreates what is possibly the most significant and enduring debate in radical politics, the debate between resistance and revolution. Indeed, it was this debate, personified by the conflict between Huey P. Newton and Eldridge Cleaver, which terminally fractured the Black Panther Party. This article first looks at Black Panther ’s use of space and setting (Oakland, California versus the fictional utopic Wakanda) in an analysis of the formation of conflictual black political identities. The article then examines how the conflict between the protagonist, the Wakandan king and Black Panther T’Challa, and the principle antagonist Eric “Killmonger” Stevens, recreates the pivotal debate, a debate that defines much of radical politics. Finally, this article uses Edward Soja’s concept of “Thirdspace” to examine the character of Nakia, arguing that she presents an alternative resistant approach to black emancipation.
Sex Differences in Cardiac Baroreflex Sensitivity after Isometric Handgrip Exercise

Purpose This study aimed to investigate potential sex-related differences on spontaneous cardiac baroreflex sensitivity (cBRS) after acute isometric handgrip (IHG) exercise. Methods Twenty men (age, 23 ± 3 yr) and 20 women (age, 24 ± 4 yr) randomly performed four sets of 2-min IHG exercise (two sets for each limb) at 30% maximal voluntary contraction (experimental) or 3% maximal voluntary contraction (sham). Beat-to-beat heart rate (HR) and arterial blood pressure (BP) were monitored using finger photoplethysmography before and 10, 20, and 30 min after IHG. Spontaneous cBRS was assessed via the sequence technique and cardiac autonomic modulation via time- and frequency-domain HR variability. Results After IHG, spontaneous cBRS increased during 10 min of recovery in men (&Dgr;13% ± 5%, P = 0.03 vs rest) and increased further in women (&Dgr;23% ± 4%, P < 0.01 vs rest; P = 0.04 vs men). During 20 and 30 min of recovery, cBRS returned to baseline in men but remained elevated in women. HR decreased 10 min after IHG in men (10 min: &Dgr;-2 ± 1 bpm, P < 0.01 vs rest; 20 min: &Dgr;-1 ± 1 bpm, P = 0.39 vs rest; 30 min: &Dgr;1 ± 1 bpm, P = 0.31 vs rest) and throughout recovery in women (10 min: &Dgr;-5 ± 1 bpm, P < 0.01 vs rest; 20 min: &Dgr;-3 ± 1 bpm, P < 0.01 vs rest; 30 min: &Dgr;-2 ± 1 bpm, P < 0.01 vs rest). Systolic BP increased 10 min after IHG and remained elevated during 20 min and 30 min in men (P < 0.05). In women, systolic BP increased during 10 min (P < 0.01) and returned to baseline during 20 and 30 min of recovery. Time-domain HR variability (root mean square of successive differences) was increased during recovery in men and women (P < 0.05). Sham had no effect on any variables. Conclusions Acute IHG exercise increases cBRS and cardiac vagal activity in healthy young subjects, but the magnitude and the time course of changes in cBRS differ between men and women.
The associations between demographic characteristics and depressionin hemodialysis patients

Introduction: Dialysis is a stressful process with several psychological and social problems that can lead to the expression of psychological disorders in patients. The aim of the present study was to investigate the relationshipsbetween the demographic variables and depression among the dialysis patients. Methods: The present study is across-sectional observation that involved all of the patients in hemodialysis centerof Shahid Mohammadi hospital of Bandar Abbas in 2012. One hundred fourteen patients were selected based on the statistical methods.Beckrs depression inventory (BDI) with 21 questions was used to collect the data. Statistics SPSS 19 software for Windows was used for the statistical analyses. A two sided a = 0.05 was considered statistically significant. Correspondence: Ali Akbar Hesam, MSc Student. Hormozgan of Fertility and Inferility Research Center, Hormozgan University of Medical Sciences. Bandar Abbas, Iran. Tel:+98 76 33337104 Email: aliakbar.hesam@yahoo.com Results: About 57.9 of the samples were males and 42.1 were females and 74.4 were single and 52.6 were married. Significant correlation (P<0.01) was found between the variables of sex, age, marital status, level of education, and income level with depression. The results showed that there was a higher depression among female patients than the male ones and also in singles compared to married patients. Concerning the income variable it was found that those with lower incomes were suffering more from depression. Conclusion: Our findings support the importance of demographic characteristics to determine the prevalence of depression in hemodialysis patients. Among demographic variables, sex, age, marital status, level of education, and income level were the most important predictors.
Método de cálculo de reajuste por variação de custos para contratos de planos de saúde suplementar a partir da teoria da credibilidade

The estimation of the percentage of adjustment for cost variation in health plan contracts is still a subjective process in the actuarial environment. The accident rate analysis, normally used as a tool in this process, can result in a biased adjustment, given the asymmetry in the probabilistic distribution of care cost data in this sector. Thus, this study aimed to develop a method of calculation for the readjustment percentage based on the Credibility Theory. For this, data from a large health care provider were used. It was concluded that the average loss ratio per contract would be 73%, which is lower than the observed loss ratio, allowing us to infer that the proposed method proved to be adequate, as, in addition to being coherent, presenting statistical and actuarial basis, it allowed for a satisfactory calculation of the readjustment, contributing both to the academic community and to the supplementary health sector, considering that this study can be the basis for calculating the readjustment that operators apply in their contracts. As limitations, the study used a historical database referring to 12 months, which can impact the efficiency of the statistical prediction model due to high variability and unpredictability scenarios.