Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Immune Response, Comorbidities andImmunomodulation in SARS-CoV2 Pandemic

SARS-CoV2 can be originate from bats or unknown intermediate hosts and cross the species barrier toward humans. Virus-host interactions affect the entry and viral replication. Virus genome encodes four essential structural proteins, the glycoprotein spike, the small envelope protein, protein arrays and nucleocapsid protein. The S glycoprotein of SARS-CoV2 binds to receptors on the host cell enzyme, angiotensin-converting enzyme 2 (ACE2), which is a critical step for the entry of viruses, it is expressed more in men than in women probably by the estradiol and testosterone that can influence in a different way the activity of ACE. It is considered a viremia phase when the virus can pass from the salivary glands and mucous membranes, in special nose and larynx, to lungs and other organs with the same receptors as heart, liver and even to the central nervous system. It can get intestines, which may explain why is detected SARS-CoV-2 in feces for up to 30 days from the start of the infection. Risk factors of the host are key to viral pathogenesis and the most recognized are an immunosuppressed status, old age, systemic arterial hypertension, diabetes mellitus or chronic lung diseases. When the immune system is inefficient to effectively control the virus in the acute phase may evolve to a serious or critical condition. The timely and accurate diagnosis of infection by SARS-CoV2 is the cornerstone of efforts to provide adequate treatment to patients, limiting the spread of the virus and ultimately, eliminating the presence of the virus in humanity. It is essential to know that treatment has several aspects, the first is during the acute and critical phase of the disease, where the life of the patient is involved and the other, is the stage in which his/her clinical condition is mild and is where it really is to recommend only isolation. However, this is something you should consider because some evolve to seriousness; this should be avoid because it implies serious health and quality life impairment with an increase of contagion. It has been suggested the use of immunostimulants, known as biological response modifiers, whose effectiveness has been demonstrated in other type of acute and recurrent viral respiratory infections.
Follicle selection by ultrasonography and plasmatic characteristics and ovulatory capacity in buffaloes

Abstract The objectives of the present work were to determine follicle deviation assessed by ultrasonography and profile of plasmatic gonadotrophins, and ovulatory capacity in buffalo species, since these information are not available in the literature. The knowledge of follicular development and gonadotrophins profile during deviation and the follicular response to an exogenous ovulation inducer can be useful tools for follicular manipulation of estrous cycle.
THE CASES OF CONSTRUCTION OF THE EU AND REFORM TREATY

The mass media are key social actors in the articulation of themes of common concern in the European public space, nowadays. Through mediation of messages, symbols and visions on important issues the media may infl uence on which themes to dominate the European public sphere. In this article we examine the patterns of media reporting on important EU-related issues, particularly the issues of Construction of the EU and Reform Treaty, in 16 European countries, incl. Turkey. We analyse the EU-related content of 77 print and broadcast media actors by focusing on two dimensions of media reporting: the frequency of reporting and the attitudes manifested by the media actors while reporting on EU-related issues. Our general fi ndings suggest that at the time of data collection (May-October 2008) there was a prevailing country-specifi c, instead of a unifi ed pattern of media reporting in Europe. Signifi cant interdependencies between the types of state membership (old, new and non-member) and the articulation of both discussed cases, as well as other topics of the EU integration in media are outlined. YOLANDA ZOGRAFOVA
Statistical Applications in Genetics and Molecular Biology Comparison of Clinical Subgroup aCGH Profiles through Pseudolikelihood Ratio Tests

Array-based Comparative Genomic Hybridization (aCGH) is a microarray-based technology that assists in identification of DNA sequence copy number changes across the genome. Examination of differences in instability phenotype, or pattern of copy number alterations, between cancer subtypes can aid in classification of cancers and lead to better understanding of the underlying cytogenic mechanism. Instability phenotypes are composed of a variety of copy number alteration features including height or magnitude of copy number alteration level, frequency of transition between copy number states such as gain and loss, and total number of altered clones or probes. That is, instability phenotype is multivariate in nature. Current methods of instability phenotype assessment, however, are limited to univariate measures and are therefore limited in both sensitivity and interpretability. In this paper, a novel method of instability assessment is presented that is based on the Engler et al. (2006) pseudolikelhood approach for aCGH data analysis. Through use of a pseudolikelihood ratio test (PLRT), more sensitive assessment of instability phenotype differences between cancer subtypes is possible. Evaluation of the PLRT method is conducted through analysis of a meningioma data set and through simulation studies. Results are shown to be more accurate and more easily interpretable than current measures of instability assessment.
Predicting Crime by Exploiting Supervised Learning on Heterogeneous Data

Crime analysis supports law-enforcing agencies in preventing and resolving crimes faster and efficiently by providing methods and techniques to understand criminal behavior patterns. Strategies for crime reduction rely on preventive actions, e.g., where perform street lighting and police patrol. The evaluation of these actions is paramount to establish new security strategies and to ensure its effectiveness. In this article, we propose a supervised learning approach that exploits heterogeneous criminal data sources, aiming to understand criminal behavior patterns and predicting crimes. Thus, we extract crime features from these data to predict the tendency of increase or decrease, and the number of occurrences of crimes types by geographic regions. To predict crimes, we exploit four learning techniques, as k-NN, SVM, Random Forest, and XGBoost. Experimental results show that the proposed approach achieves up to 89% of accuracy and 98% of precision for crime tendency, and up to 70% of accuracy and 79% of precision for crime occurrence. The results show that Random Forest and XGBoost usually perform better when trained with a short time window, while k-NN and SVM perform better with a longer time window. Moreover, the use of heterogeneous sources of data can be effectively used by supervised techniques to improve forecast performance.
Understanding Query Interfaces: Automatic Extraction of Data from Domain-specific Deep Web based on Ontology

The resources of many Web-accessible databases, which are a very large portion of the structured data on the Web, are only available through query interfaces but are invisible to the traditional search engines. Many methods, which discovery these resources automatically, rely on the different structures of Web pages and various designing modes of databases. However, some semantic meanings and relations are ignored. Here we introduce a Web information retrieval system that obtains the knowledge from multiple databases automatically by using common ontology WordNet. Also, deep Web query results are post-processed based on domain ontology. That is, given an integrated interface, after inputting a query, our system offers an ordered list of data records to users. We have conducted an extensive experimental evaluation of the Web information retrieval system over real documents. Also, we test our system with hundreds of databases on different topics. Experiments show that our system has low cost and achieves high discovering accuracy across multiple databases.
Sequencing Operator Counts with State-Space Search

A search algorithm with an admissible heuristic function is the most common approach to optimally solve classical planning tasks. Recently Daviesetal. (2015) introduced the solver OpSeq using Logic-Based Benders Decomposition to solve planning tasks optimally. In this approach, the master problem is an integer program derived from the operator-counting framework that generates operator counts, i.e., an assignment of integer counts for each task operator. Then, the operator counts sequencing subproblem verifies if a plan satisfying these operator counts exists, or generates a necessary violated constraint to strengthen the master problem. In OpSeq the subproblem is solved by a SAT solver. In this paper we show that operator counts sequencing can be better solved by state-space search. We introduce OpSearch, an A∗-based algorithm to solve the operator counts sequencing subproblem: it either finds an optimal plan, or uses the frontier of the search to derive a violated constraint. We show that using a standard search framework has two advantages: i) search scales better than a SAT-based approach for solving the operator counts sequencing, ii) explicit information in the search frontier can be used to derive stronger constraints. We present results on the IPC-2011 benchmarks showing that this approach solves more planning tasks, using less memory. On tasks solved by both methods OpSearch usually requires to solve fewer operator counts sequencing problems than OpSeq, evidencing the stronger constraints generated by OpSearch.
EFFECTS OF INTRAVITREAL AFLIBERCEPT (EYLEA) IN THE TREATMENT OF BILATER- AL CYSTOID MACULAR EDEMA IN RETINITIS PIGMENTOSA – A CASE REPORT EFFEKTI INTRAVITREALNOG AFLIBERCEPTA (EYLEA) U LEČENJU BILATERALNOG CISTOIDNOG EDEMA KOD RETINITIS PIGMENTOSAE – PRIKAZ SLUČAJA

The term retinitis pigmentosa (RP) refers to a group of hereditary conditions [1] also known as retinal dystrophy. It is caused by the loss of photoreceptors, and is clinically characterized by retinal pigment deposits visible on fundus examination [2]. The disease can be inherited as an autosomal-domSummary Introduction. The aim of the study was to evaluate the effects of intravireal injections of aflibercept (Eylea) on bilateral cystoid macular edema in a patient with retinitis pigmentosa. Material and Methods. A 17-year-old man presented with a moderate bilateral decrease of visual acuity (0.3) and ocular examination was performed. Optical coherence tomography imaging was performed and cystoid macular edema was detected in both eyes. Due to disease progression in a short period of time, intravitreal repeated injections of aflibercept (Eylea) were initiated according to recent clinical reports. Results. The initial values of cystoid macular edema before intravitreal therapy were 248 μm in the right and 237 μm in the left eye; they increased slowly in next several weeks. Four bilateral repeated doses of intravitreal aflibercept injections at 6-week intervals were given in local anesthesia. The patient reported a subjective improvement, and his visual acuity was 4/10 in both eyes. Objectively, the macular edema decreased at week 24, reaching 173 μm in the right and 188 μm in the left eye. Conclusion. There are few literature reports on the possible effects of intravitreal aflibercept injections in the treatment of retinitis pigmentosa-related cystoid macular edema. In our study, bilateral macular edema in a patient with retinitis pigmentosa has improved significantly after four consecutive treatments. Further studies are necessary with a larger sample size and longer follow-up period to obtain information on the role and safety of intravitreal drugs for cystoid macular edema in retinitis pigmentosa.
Software Similarity Patterns and Clones: A Curse or Blessing?

: Similarities are inherent in software. They show as software clones – similar code fragments, functions, classes, source files, and bigger program structures spreading through software systems in multiple variant forms. Often, these recurring program structures represent important concepts from software requirements or design spaces. Interestingly, despite potential benefits, avoiding many of such redundancies is often either impossible or would require developers to compromise important design goals. In this paper, I discuss software similarity phenomenon, its sources, the many roles clones play in programs, the software productivity benefits that can be gained by avoiding clones, and difficulties to realize these benefits with conventional programming languages and design techniques. I point to generative techniques as a promising approach to address software redundancy problems.
AN ANALYSIS OF SPECIES DISTRIBUTION PATTERNS IN THE ATLANTIC FORESTS OF SOUTHEASTERN BRAZIL

This study analysed phytogeographic patterns of several Atlantic Forest areas in southeastern Brazil, including forest areas in the Espinhaco Range, to identify species with congruent distribution patterns and possible environmental factors that might influence these. A total of 54 floristic surveys, predominantly from semideciduous woodland sites but also including some rainforest areas, were compared using UPGMA and DCA methods as well as Jaccard analyses. The former identified four main groupings: group 1 included forests located throughout the Espinhaco Range; group 2 was formed by forest areas in the Rio Jequitinhonha basin; group 3 was formed by three distinct subgroups, one (3.1) predominantly of forest areas pertaining to the Alto Rio Grande basin, another (3.2) of upland forests of the Quadrilatero Ferrifero, and a third subgroup (3.3) of upland forests of the Serra da Mantiqueira; and group 4 encompassed forest areas in the Rio Doce, Rio Paraiba do Sul, Rio Itanhem and Rio Itapemirim basins. The prevailing relief in these basins has influenced rainfall and seasonality in these areas which, in turn, have exerted a major influence on the composition of the semideciduous forests. Geographic proximity and altitude, although important factors, play a minor role in the phytogeographic patterns analysed. Despite the floristic heterogeneity of the Espinhaco Range forests, there are physiognomic and floristic affinities among the forests within the campos rupestre vegetation. These are due to the high altitude and features of the soil.
DNA Barcoding in Plants and Current Molecular Issues

DNA barcoding especially used in the field of molecular biology that uses primers with 500-700 segments to classify various species at molecular and genetic level. This review focuses on the role of DNA barcoding in conservation of biodiversity and current applications for the discovery of species. Some species of plants and animals remain unidentified at molecular level. DNA barcoding uses molecular tools for the discovery of species found in natural ecosystem and playing important role in biodiversity conservation. Genetic barcoding mainly focuses on conservation strategies on populations due to differences found in the mitochondrial DNA. The most commonly used DNA barcodes for the plant species are ITS, rbcL, psbA-trnH and matK. DNA barcodes has several applications for the detection of plants species by providing specific information about the taxa. There is need to use DNA barcoding in combinations with other sciences such as ecology and taxonomy methods for conservation of biodiversity. There is also need to use databases for appropriate storage of data about species to conserve biodiversity.
EFFECT OF YOGA AND AEROBIC EXERCISES ON SELECTED RED BLOOD CELLS AND MEAN ARTERIAL BLOOD PRESSURE AMONG OBESE MEN

The purpose of the study was to find out the effect of yoga and aerobic exercise on selected red blood cell and mean arterial blood pressure among obese men. The subjects were divided into three groups (n=20) at random. Group I underwent yogic practices, Group II underwent aerobic exercise and Group III acted as control group. The study consisted of pre test and post test. Pre test and post test were conducted for all the subjects on selected hematological (red blood cells) physiological variables (mean arterial blood pressure) among obese men. The data obtained were analyzed by Analysis of Covariance (ANCOVA) to assess the significant difference among the groups on red blood cell and mean arterial blood pressure variables to find out the effects of yoga and aerobic exercise among obesity men. The ’F’ ratio obtained by Analysis of Covariance were compared at 0.05 level of significance. It is concluded that yogic practices to be significantly beneficial in enhancing the Red blood cells the selected bio hematological variablered blood cells, and the selected physiological variablereduced mean arterial blood pressure among obesity middle aged men than the control group. Aerobic exercise also to be significantly beneficial in enhancing the Red blood cells effectively the selected hematological variable red blood cells and the selected physiological variable – reduced mean arterial blood pressure among obesity middle aged men than the control group. It is found that yogic practices are slightly effective than aerobic exercise on the selected hematological variable red blood cells – and physiological variables variable – mean arterial blood pressure.
Structural Characterization of Normal and Mutant Human Steroid 17α- Hydroxylase Genes: Molecular Basis of One Example of Combined 17α- Hydroxylase/17,20 Lyase Deficiency

Steroid 17α-hydroxylase (cytochrome P-45017α) catalyzes both 17α-hydroxylation of pregnenolone and progesterone and 17,20-lysis of 17α-hydroxypregnenolone and 17α-hydroxyprogesterone. In the course of undertaking detailed investigation of the structure-function relationships which exist within this enzyme we have begun to elucidate the molecular basis of human deficiencies in either or both of these activities. Consequently we have determined the exonic structure of the human P-45017α gene as well as the sequences at the exon/intron boundaries and at the site of initiation of transcription. A single gene in the human genome encodes this protein, being the sole member of a unique gene family (P450XVII) within the P-450 supergene family. A protocol for exonic sequencing of the P-45017α gene has been established which permits structural analysis of the gene from patients having 17α-hydroxylase and/or 17,20-lyase deficiency. This procedure has been applied to the mutant gene from one individual having combine.
Sucrose/cytokinin interaction in Sinapis alba at floral induction: a shoot‐to‐root‐to‐shoot physiological loop

In plants of Sinapis alba induced to flower by exposure to a single long day (LD), previous work demonstrated that the movement of a shoot-to-root signal early during the photoextension period of the LD was essential for flowering. Interrupting this movement by bark ringing (girdling) of the stem inhibited the floral response of plants to the LD. In the present work we show that (a) the girdling treatment decreases the soluble sugar level in the roots of induced plants, and (b) the inhibitory effect on the floral response caused by girdling can be completely overcome by supplying the roots with sucrose directly at appropriate times. Thus, we demonstrate that sucrose moving in the phloem is the shoot-to-root signal essential for flowering. We have also found that one of the major effects of the extra-sucrose on the roots is to stimulate the root-to-shoot movement of [9R]Z, the predominant cytokinin of the xylem sap in Sinapis. The importance of this upward movement of [9R]Z for flowering is indicated by the observation that (a) the floral response to the LD is inhibited by growing plants in an atmosphere saturated with water (impairing upward movement of xylem sap) during the LD itself, and (b) the inhibitory effect on the floral response caused by girdling, which markedly reduces [9R]Z export from roots, is relieved by direct application of BA, a cytokinin, to the apex. Other possible effects of the shoot-derived sucrose on roots in relation to flowering are also discussed. Our results show that a shoot-to-root-to-shoot physiological loop is essential for flowering in intact Sinapis plants.
Effect of salinomycin on in vitro caecal fermentation in pigs

Summary The effect of salinomycin was investigated in anaerobic incubations of the pig caecal contents collected at slaughter, diluted with buffer and either supplied with starch or not. Salinomycin was present in cultures at 0, 2, 5 and 10 mg/l. In the whole range of concentrations that were tested, salinomycin significantly increased the production of propionate at the expense of acetate and butyrate. At 5 and 10 mg/l, these fermentation shifts were accompanied by a significant decrease of the total VFA, gas and methane production. The formation of molecular hydrogen which was low in control incubations without substrate (0.20 mmol/l), was increased in the salinomycin-treated cultures with starch (1.30 mmol/l). Salinomycin tended to decrease the synthesis of microbial protein, but its effect was not significant. The metabolic hydrogen recovery was significantly increased in salinomycin-treated cultures, indicating a partial inhibition of acetate formation from CO2 and H2. Zusammenfassung Der Einflus von Salinomycin auf die caecale Fermentation in vitro bei Schweinen. Es wurde der Einflus von Salinomycin auf einige Metabolite und die mikrobielle Proteinsynthese mit Hilfe der anaeroben Inkubation von Blinddarminhalt bei Mastschweinen untersucht. Die Schweine erhielten vor der Schlachtung Kraftfutter. Der Blinddarminhalt wurde mit Puffer verdunnt und unter Zusatz von 0, 2, 5 und 10 mg/l Salinomycin mit oder ohne Starke als Substrat inkubiert. Der Zusatz von Salinomycin fuhrte zu einer signifikanten Erhohung der Propionat-Konzentration auf Kosten von Acetat und Butyrat. Bei hoherer Salinomycin-Konzentration (5 und 10 mg/l) waren die unterschiedlichen Verhaltnisse in den fluchtigen Fettsauren von einer Verminderung der gesamten Produktion an fluchtigen Fettsauren, Methan und Gargasen begleitet. Die Entstehung von molekularem Wasserstoff, die bei der Inkubation ohne Starke als Substrat niedriger (0, 20 mmol/l) lag, betrug mit Starke und Salinomycin 1, 30 mmol/l). Der Zusatz von Salinomycin erniedrigte die Synthese von mikrobiellem Protein. Allerdings war dieser Effekt nicht signifikant.