Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapeutic clowning in paediatric practice

Over the past 30 years, there has been much research into the health benefits of humour and laughter. Although often viewed very positively, rigorous evaluation of the therapeutic effect of clowning is complex. Clowning is a multi-modal intervention, which may have an impact on medical conditions, procedures, family functioning and health care teams. Clowns help children to adapt to their hospital surroundings and can distract from, and demystify, painful or frightening procedures through ‘doses of fun’ to complement traditional clinical interventions. This paper provides a review of the paediatric literature and reveals studies looking at the effect of clown interventions on various practical procedures and individual medical conditions, and the effects of clowning within clinical teams.
Hsp 90 : a chaperone for protein folding and gene regulation 1

Molecular chaperones are essential components of a quality control machinery present in the cell. They can either aid in the folding and maintenance of newly translated proteins, or they can lead to the degradation of misfolded and destabilized proteins. Hsp90 is a key member of this machinery. It is a ubiquitous molecular chaperone that is found in eubacteria and all branches of eukarya. It plays a central role in cellular signaling since it is essential for maintaining the activity of several signaling proteins, including steroid hormone receptors and protein kinases. Hsp90 is currently a novel anticancer drug target since it is overexpressed in some cancer cells. The chaperone typically functions as part of large complexes, which include other chaperones and essential cofactors that regulate its function. It is thought that different cofactors target Hsp90 to different sets of substrates. However, the mechanism of Hsp90 function remains poorly understood. As part of an effort to elucidate the Hsp90 chaperone network, we carried out a large-scale proteomics study to identify physical and genetic interactors of the chaperone. We identified 2 highly conserved novel Hsp90 cofactors, termed Tah1 and Pih1, that bind to the chaperone and that also associate physically and functionally with the essential DNA helicases Rvb1 and Rvb2. These helicases are key components of the chromatin remodeling complexes Ino80 and SWR-C. Tah1 and Pih1 seem to represent a novel class of Hsp90 cofactors that allow the chaperone to indirectly affect gene regulation in the cell in addition to its ability to directly promote protein folding. In this review, we provide an overview of Hsp90 structure and function, and we discuss the literature that links the chaperone activity to gene regulation.
Blood flow changes and vascular appearance in preovulatory follicles and corpora lutea in immature, pregnant mare's serum gonadotropin-treated rats.

In the present study, synchronized follicular growth, ovulations, and luteogenesis were prematurely induced in 26-day-old immature rats by the s.c. injection of 4 IU of pregnant mare's serum gonadotropin (PMSG) at 2100 h. Relative blood flow of follicles/corpora lutea, fallopian tube, and uterus was measured with radioactive microspheres during the periovulatory period (Day 28, 1700 h-Day 31, 1300 h). Also, follicular/corpus luteal light microscopy and plasma progesterone were studied at the same intervals after PMSG injection. It was found that the relative follicular blood flow did not increase after the endogenous gonadotropin surge (Day 29, 0300-0500 h) and toward ovulation (Day 29, 1300-1500 h). During the same time period, light microscopy showed an interstitial edema and extravasation of erythrocytes appearing in the follicular wall near the time of ovulation. The relative blood flow reached its nadir in the young corpus luteum (21 h after ovulation) and increased thereafter (i.e., 48 h after ovulation). Plasma progesterone showed a preovulatory increase and then declined just prior to the ovulatory period. Between 24 and 48 h after ovulation, parallel increases in relative blood flow, morphological vascularization, morphological luteinization, and plasma progesterone levels were observed in the growing corpus luteum. These data indicate that a functional relationship between blood flow and steroid output may exist within the ovarian follicle and corpus luteum.
The Effect of Arch Height and Material Hardness of Personalized Insole on Correction and Tissues of Flatfoot

Flat foot is one of the common deformities in the youth population, seriously affecting the weight supporting and daily exercising. However, there is lacking of quantitative data relative to material selection and shape design of the personalized orthopedic insole. This study was to evaluate the biomechanical effects of material hardness and support height of personalized orthopedic insole on foot tissues, by in vivo experiment and finite element modeling. The correction of arch height increased with material hardness and support height. The peak plantar pressure increased with the material hardness, and these values by wearing insoles of 40° were apparently higher than the bare feet condition. Harder insole material results in higher stress in the joint and ligament stress than softer material. In the calcaneocuboid joint, the stress increased with the arch height of insoles. The material hardness did not apparently affect the stress in the ankle joints, but the support heights of insole did. In general, insole material and support design are positively affecting the correction of orthopedic insole, but negatively resulting in unreasonable stress on the stress in the joint and ligaments. There should be an integration of improving correction and reducing stress in foot tissues.
Immune-adherence with soluble antigens.

Immune-adherence has been demonstrated by haemagglutination with four soluble antigens, two polysaccharide and two protein. A zone phenomenon occurs with the immune-adherence of soluble antigens similar to that found with other antigen-antibody reactions. It is suggested that the failure of immune-adherence with two soluble antigens, despite marked fixation of complement, is due to the failure of the antigen-antibody complexes to fix all four components of complement.
Reduction of regression tests for Erlang based on impact analysis

Refactoring is a widely used technique in the software development and maintenance process. However refactorings should preserve the original behaviour of the system, developers want to be convinced about that, thus they retest the software after some modifications. Software testing is said to be the most expensive part of the lifecycle of software systems. Therefore our research focuses on impact analysis of changes to select test cases affected by refactorings that should be retested after the transformations. We describe the used mechanism in case of a dynamically typed functional programming language, Erlang.
Data Warehousing , Data Mining , OLAP and OLTP Technologies Are Indispensable Elements to Support Decision-Making Process in Industrial World

This paper provides an overview of Data warehousing, Data Mining, OLAP, OLTP technologies, exploring the features, new applications and the architecture of Data Warehousing and data mining. The data warehouse supports on-line analytical processing (OLAP), the functional and performance requirements of which are quite different from those of the online transaction processing (OLTP) applications traditionally supported by the operational databases. Data warehouses provide on-line analytical processing (OLAP) tools for the interactive analysis of multidimensional data of varied granularities, which facilitates effective data mining. Data warehousing and on-line analytical processing (OLAP) are essential elements of decision support, which has increasingly become a focus of the database industry. OLTP is customer-oriented and is used for transaction and query processing by clerks, clients and information technology professionals. An OLAP system is market-oriented and is used for data analysis by knowledge workers, including managers, executives and analysts. Data warehousing and OLAP have emerged as leading technologies that facilitate data storage, organization and then, significant retrieval. Decision support places some rather different requirements on database technology compared to traditional on-line transaction processing applications.
Principles-Based versus Rules-Based Accounting Standards and Extreme Cases of Earnings Management

In this study, I investigate whether characteristics that are commonly claimed to indicate whether a standard is principles-based or rules-based are associated with the dollar magnitude of earnings management, the probability of being penalized for earnings management, and the penalty assessed to firms that manage earnings. To address these questions, I develop an instrument that measures the extent to which a standard contains rules-based characteristics. I identify earnings management firms as those firms that restate earnings due to fraud or whose restatement is investigated by the SEC. Finally, I determine whether the SEC penalized earnings management firms by issuing an enforcement action. I find that the SEC is less likely to issue an enforcement action when a firm violates a standard that has more rules-based characteristics. If executives realize they are less likely to be penalized for a rules-based violation, then I expect executives to manage the dollar amount of earnings more when standards contain rules-based characteristics. Consistent with this notion, I find the dollar magnitude of earnings management is greater when an executive violates a standard that has more rules-based characteristics. Principles-Based versus Rules-Based Accounting Standards and Extreme Cases of Earnings Management
NodeLeaper: Lower Overhead Oblivious AVL Tree

Obliviousness is crypto primitives which intent to hide access pattern. Although ORAM is strongest crypto model, it incurs significant overhead. Elaine Shi et. al. propose Obliviousness Data Structrue (ODS) that makes a great theriotical improvement comparing to general ORAM algorithm, in case of the data blocks exhibit some degree of access predictability. Take AVL tree as an example, when all data blocks are organized as one AVL tree, every nodes (data blocks) contain position information points to both of its child node. As such, the client can immediately obtain the next position to be accessed instead of issuing another ORAM access to the server for a PosMap lookup. Also, the algorithm need extra client space for updating the AVL tree.In this paper, we introduce oblivious AVL tree NodeLeaper, NodeLeaper for short, which enables position information of all child nodes to share part of bits. As such one can store multiple positions for is child and grandson node positions with same block size. In this way, the search can be processed in a leap manner. As a result, NodeLeaper theriotically needs less ORAM accessand client space for node updating than ODS.
Histological and histochemical evaluations on the effects of high incubation temperature on the embryonic development of tibial growth plate in broiler chickens

The effects of experimentally induced high incubation temperature on the embryonic development of growth plate of the chicken were investigated by means of histological and enzyme histochemical methods. In the experiments, 250 fertile eggs of Ross‐308 broiler strain were divided into two groups, the control eggs were maintained under optimal conditions (37.8°C and 65% ± 2% relative humidity, rh) during the whole incubation period. Heat‐stress imposed eggs were maintained under normal conditions (37.8°C and 65% ± 2% rh) until the 10th day of incubation, and then, continuously (24 h per day) exposed to high temperature (38.8°C and 65% ± 2% rh). Tissue samples were taken from 10 animals of each group at the 11th, 13th, 15th, 18th, 21st days of incubation. Tissue samples were processed by enzyme histochemical methods in addition to routine histological techniques. The relative tibia weights and tibia length were lower in the heat‐stress group compared to the control group. The results of the measurements of the growth plate showed that the proliferative zone was narrowed whereas, the transitional and hypertrophic zone were thickened in the heat stress group. Alkaline phosphatase (ALP) density was significantly decreased in the heat‐stress group compared to the control group. In conclusion, bone formation and growth plate formation are crucial for embryo development and 1°C higher from optimum may increase the incidence of skeletal disorders and leg problems in broiler chickens which is one of the major animal welfare concerns for the poultry industry. Microsc. Res. Tech. 79:106–110, 2016. © 2016 Wiley Periodicals, Inc.
Abdominal regional in-situ perfusion in donation after circulatory determination of death donors

Purpose of reviewProvide an overview regarding the current state of abdominal regional perfusion (ARP) in donation after circulatory determination of death (DCD) organ transplantation, including the principles behind how ARP functions and the most recent results of its clinical application. Recent findingsARP has been applied clinically in DCD at both hypothermic and normothermic temperatures. The use of hypothermic perfusion has primarily been limited to DCD kidney transplantation, whereas normothermic regional perfusion has been used to improve and assess the quality of DCD kidneys, livers, and even a handful of pancreata for transplantation. Results of recent single-center series reflect acceptable rates of early graft function and survival using grafts that might have otherwise been discarded. SummaryARP is an important form of donor maintenance that helps improve DCD organ viability and may help expand the applicability of transplantation using organs arising through this process.
QoS Sensitive VANET Control Scheme based on Feedback Game Model

As a special type of mobile ad-hoc network, Vehicular Ad-hoc Network (VANET) is considered as an attractive topic by many researchers. In VANETs, vehicles act as routers and clients, which are connected with each other through unreliable wireless links. Due to the dynamic nature of vehicles, developing communication protocols for VANETs is a challenging task. In this paper, we tackle the problem of real-world VANET operations and propose a new dual-level communication scheme through the combination of power and rate control algorithms. Based on the game theoretic approach, the proposed scheme effectively formulates the interactive situation among several vehicles. With a simulation study, it is confirmed that the proposed scheme can achieve better performance than other existing schemes under widely diverse VANET environments.
The Chronicity of Schizophrenia in Indigenous Tropical Peoples

Although the belief that primitive man might be free from schizophrenia has joined the rest of the golden age myths, there is still a serious question respecting the severity or chronicity of the disease in many tropical peoples. In such peoples typical cases of schizophrenia are proportionately uncommon, and in their place one often meets an acute short-lasting psychosis, which may be indistinguishable from classical schizophrenia in its initial stages but which runs a much shorter course and carries a better prognosis.
Modeling and performance assessment of pontoon roller wave energy converter in Singapore

Wave energy generation is one of the promising renewable energy generation systems. It has broad distribution around the world, with enormous potential. In this paper, the electrical characteristics of a pontoon roller wave energy converter (WEC) is presented. The pontoon roller WEC is located at the Tanah Merah Ferry Terminal (TMFT), Singapore. The paper shows the WEC system deployed at TMFT, Singapore. The power generation system is developed from the wave turbine, which is a roller operated by the wave through the pontoon with the gear box, connected to the permanent magnet generator (PMG). The generated power from the PMG is passed through the AC/DC rectifier, and the DC/DC buck converter with maximum power point tracking (MPPT) algorithm, to the battery bank, and to the DC/DC boost converter with DC/AC inverter to cater the consumer load. Detailed physical and simulation models of the different subsystems are presented. The paper presents the real measured results at TMFT, Singapore, and comparison of the real measured power output with the simulated results.
Late gadolinium enhancement cardiac magnetic resonance imaging for the prediction of ventricular tachyarrhythmic events: a meta‐analysis

Approaches to the risk stratification for sudden cardiac death (SCD) remain unsatisfactory. Although late gadolinium enhancement cardiac magnetic resonance imaging (LGE‐CMR) for SCD risk stratification has been evaluated in several studies, small sample size has limited their clinical validity. We performed this meta‐analysis to better gauge the predictive accuracy of LGE‐CMR for SCD risk stratification.
Humoral stimulation of adrenal cortical secretion.

II, 4 per cent glucose with 20 mEq per L KCl added at 1.5 Ml per minute; and 2) intravenous infusion of angiotensin II and ab-ACTH. The systemic blood pressure during intravenous infusion of angiotensin II is recorded also.
Genome Sequence of Streptomyces griseus Strain XylebKG-1, an Ambrosia Beetle-Associated Actinomycete

ABSTRACT Streptomyces griseus strain XylebKG-1 is an insect-associated strain of the well-studied actinobacterial species S. griseus. Here, we present the genome of XylebKG-1 and discuss its similarity to the genome of S. griseus subsp. griseus NBRC13350. XylebKG-1 was isolated from the fungus-cultivating Xyleborinus saxesenii system. Given its similarity to free-living S. griseus subsp. griseus NBRC13350, comparative genomics will elucidate critical components of bacterial interactions with insects.
The role of risk communication in shared decision making

First let's get to choices I want to feel like a rational and autonomous person, even when I'm ill. Doctors ought to use their power (legal and knowledge) not only to relieve suffering but to enhance patients' autonomy.1 A prescription for this is shared decision making, a middle ground between “nanny knows best” paternalism and rampant consumerism–an ideal that aims to reconcile the fact of professional power with the ethic of informed choice. Laws are leaning towards informed choice. For example, the supreme court of Canada in 1980 ruled that doctors have a legal obligation to disclose, unasked, whatever a reasonable person in that patient's particular position would want to know before making a decision. The ethical positions of medical guilds have more or less followed suit: “Duties of a doctor [are to] give patients information in a way they can understand; respect the rights …
The role of neutrophils in injury and repair following muscle stretch

Stretch injury to the myotendinous junction is a common problem in competitive athletes and those involved in regular physical activity. The major risk factor for recurrent injury appears to be the primary injury itself. Physicians, physical therapists, athletic trainers and athletes alike continue to search for optimal treatment and prevention strategies. Acute inflammation is regarded as the body's generalized protective response to tissue injury. An especially important and unexplored aspect of inflammation following injury is the role of inflammatory cells in extending injury and possibly directing muscle repair. It has been suggested that the inflammatory reaction, although it typically represents a reaction to damage and necrosis, may even bring about some local damage of its own and therefore increase the possibility for scarring and fibrosis. Limiting certain aspects of inflammation may theoretically reduce muscle damage as well as signals for muscle scarring. Here we focus on the role of neutrophils in injury and repair of stretch‐injured skeletal muscle. A minimally invasive model that generates a reproducible injury to rabbit skeletal muscle is presented. We present a plausible theory that neutrophil‐derived oxidants resulting from the initial stretch injury are responsible for extending the damage. An anti‐CD11b antibody that blocks the neutrophil's respiratory burst is employed to reduce myofibre damage. An intriguing area that is currently being explored in our laboratory and others is the potential role for neutrophils to contribute to muscle growth and repair. It may be possible that neutrophils facilitate muscle repair through removal of tissue debris as well as by activation of satellite cells. Recent and ongoing investigations point to interleukin‐6 as a possible key cytokine in muscle inflammation and repair. Studies to elucidate a clearer understanding of this possibility will be reviewed.
cAMP-independent Activation of the Adenovirus Type 12 E2 Promoter Correlates with the Recruitment of CREB-1/ATF-1, E1A12S, and CBP to the E2-CRE*

Expression of the transcription unit early region 2 (E2) is of crucial importance for adenoviruses because this region encodes proteins essential for viral replication. Here, we demonstrate that the E1A12S protein of the oncogenic adenovirus serotype 12 activates the E2 promoter in dependence of the N terminus and the conserved region 1. Activation is mediated through a cAMP-response element that is bound by CREB-1 and ATF-1. Moreover, the Ad12 E2 promoter is inducible by protein kinase A and repressed by either a dominant-negative cAMP-response element-binding protein (CREB) mutant or the highly specific protein kinase A inhibitor protein underscoring the participation of CREB-1/ATF-1 in promoter activation. E1A12S binds to CREB-1 and ATF-1 in dependence of the N terminus and CR1 and is recruited to the E2 cAMP-response element through both cellular transcription factors. Most interestingly, point mutations revealed that E1A12S domains essential for binding to CREB-1/ATF-1 and for activation of the Ad12 E2 promoter are also essential for binding to the CREB-binding protein. Due to these data and results obtained in DNA-dependent protein-protein interaction assays, we propose a model in which the cAMP-independent activation of the Ad12 E2 promoter is mediated through a ternary complex consisting of CREB-1/ATF-1, E1A12S, and CREB-binding protein, which assembles on the E2 cAMP-response element.
piggyBac‐mediated germline transformation in the beetle Tribolium castaneum

The lepidopteran transposable element piggyBac can mediate germline insertions in at least four insect orders. It therefore shows promise as a broad‐spectrum transformation vector, but applications such as enhancer trapping and transposon‐tag mutagenesis are still lacking. We created, cloned, sequenced and genetically mapped a set of piggyBac insertions in the red flour beetle, Tribolium castaneum. Transpositions were precise, and specifically targeted the canonical TTAA recognition sequence. We detected several novel reporter‐expression domains, indicating that piggyBac could be used to identify enhancer regions. We also demonstrated that a primary insertion of a non‐autonomous element can be efficiently remobilized to non‐homologous chromosomes by injection of an immobile helper element into embryos harbouring the primary insertion. These developments suggest potential for more sophisticated methods of piggyBac‐mediated genome manipulation.