Miracle-dz/UniFAR-FTUs huggingface dataset:
PENGARUH PROMOSI DAN WORD OF MOUTH TERHADAP KEPUTUSAN BERKUNJUNG MELALUI DESTINATION IMAGE (Studi Kasus pada Wisatawan Grand Maerakaca Semarang)

Tourism is one of the potential business sectors because the community's need to travel continues to increase. Grand Maerakaca is a type of artificial tourism that has the concept of culture and education about the culture of Central Java. Grand Maerakaca is one of the leading tourist destinations in Semarang, but because there are still problems in the Grand Maerakaca, tourists are hesitant to visit. This type of research is explanatory research, using a questionnaire as a method of data collection. The research method used is the Non Probability Sampling technique with Purposive Sampling and Accidental Sampling methods. Samples collected as many as 100 respondents of Grand Maerakaca Semarang tourists were selected based on consideration. The study uses a Partial Least Square analysis technique, which is estimated with the WarpPLS 6.0 program. The results of the analysis by WarpPLS explain that the test results of the direct effect on the research model are the influence of Promotion on Visiting Decisions showing positive and significant results, the influence of Word of Mouth on Visiting Decisions shows positive and significant results, the effect of Promotion on Destination Image shows positive and significant results, Word of Mouth towards Destination Image shows positive and significant results, and the effect of Destination Image on Visiting Decisions shows positive and significant results. Test the indirect effect on the research model that is the effect of Promotion of Visiting Decisions through Destination Image shows positive and significant results, the effect of Word of Mouth on Visiting Decisions through Destination Image shows positive and significant results. Researchers give advice to the Grand Maerakaca based on the lowest recapitulation value given by respondents to the assessment indicators, namely adding detailed information on their social media, stimulating positive word of mouth, considering making iconic entrance access, and continuing to increase the quantity and quality of promotions on social media. which is close to potential tourists.
Hybrid modelling of biological systems using fuzzy continuous Petri nets

Abstract Integrated modelling of biological systems is challenged by composing components with sufficient kinetic data and components with insufficient kinetic data or components built only using experts’ experience and knowledge. Fuzzy continuous Petri nets (FCPNs) combine continuous Petri nets with fuzzy inference systems, and thus offer an hybrid uncertain/certain approach to integrated modelling of such biological systems with uncertainties. In this paper, we give a formal definition and a corresponding simulation algorithm of FCPNs, and briefly introduce the FCPN tool that we have developed for implementing FCPNs. We then present a methodology and workflow utilizing FCPNs to achieve hybrid (uncertain/certain) modelling of biological systems illustrated with a case study of the Mercaptopurine metabolic pathway. We hope this research will promote the wider application of FCPNs and address the uncertain/certain integrated modelling challenge in the systems biology area.
Dignity in end-of-life care at hospice An Action Research Study

Background: Safeguarding the dignity of patients at the end of life is a key objective in palliative care practice in Denmark. The concept of dignity and how it influences a dying persons’ quality of life is thus influential in end-of-life care at hospices. However, what is meant by dignity, how dignity is understood and practiced by healthcare professionals in Danish hospices, and whether this relates to the patients’ understandings and needs concerning dignity remains unanswered. Aim: The aim of this study was to explore and improve dignity in care through an action research study with patients and hospice staff at two different hospices in Denmark. This was done by exploring how patients and health care professionals expressed their understandings and needs concerning dignity and involving participants in the research process with the goal of improving dignity in care. Methods: An action research method with reflection-of-praxis and action-in-praxis was applied. It was combined with methods of semi-structured individual interviews with twelve patients, five staff, and nine focus-group interviews with staff. theoretical model on dignity presented in the study also worked as a map to guide staffs’ reflections on dignity in praxis and facilitated a broader focus on supporting and caring for patients’ dignity in care. We believe this study has improved dignity in care at the two hospices involved in the study.
SISTEMAS TUTORES INTELIGENTES COMO RECURSO DIDÁTICO NO ENSINO DA MATEMÁTICA

O presente trabalho tem como objetivo potencializar a elaboracao e uso de novas ferramentas tecnologicas que venham a contribuir como recurso didatico no processo ensino-aprendizagem. Nesta perspectiva, este projeto tem a ideia de utilizar o computador como uma ferramenta no auxilio didatico. Apresentando um prototipo, desenvolvido atendendo aos requisitos de fundamentos de Sistemas Tutores Inteligentes (STI). Neste caminho, foi implementado o software educacional, sob STI, para solucionar ou minimizar problemas de assimilacao de conteudos matematicos, no qual os alunos sejam capazes de registrar informacoes relevantes, fazer exercicios e provas, gerenciar consultas e retornos de atividades, emitir relatorios, visualizar notas e rendimento.
Direct current magnetron coating chamber characterization directed toward the efficient development of broadband x-ray optic multilayer coatings

Abstract. A direct current (DC) magnetron sputtering system has been developed at NASA Marshall Space Flight Center for depositing broadband x-ray optic multilayer coatings. The system has the capability to house up to four, 2-in. -diameter direct-cooled DC magnetron cathodes. The 2-in. -diameter cathodes facilitate low-cost, early stage research and development of various types of optical coatings. Despite the small target diameter, good coating uniformity on 4-in. -diameter substrates is demonstrated. Sources of both systematic and random error in the deposition of depth-graded multilayer coatings were identified and compensated for, resulting in the ability to deposit coating that required ∼7.5 h of total deposition time. Final verification of the system was concluded with the deposition of an NuSTAR W/Si depth-graded multilayer coating design (flight recipe 10).
The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Utility and Advantages of the Eccentric Training through the Isoinertial System

We are glad to introduce the first Journal Club of volume five, the first issue. This edition is focused on relevant studies published in the last years in the field of eccentric training, chosen by our editorial board members and their colleagues. We hope to stimulate your curiosity in this field and to share with you the passion for the sport, seen also from a scientific point of view. The editorial board members wish you an inspiring lecture.
EVOLUTIONARY HISTORY OF THE SOX GENES THROUGHOUT GENE DUPLICATION

Sox gene family encodes important transcription factors involved in early stages of embryonic development. They contain a conserved region called HMG-box which is at least 50% similar to the HMG-box of Sry gene. Several phylogenetic models have been proposed for a better understanding of their evolution suggesting a possible emergence in the last common ancestor, and a posterior divergence in early metazoans due to several genome duplication events. Duplicated copies acquired new functions or went through sub-functionalization leading to the emergence of new gene sub-families in different animal clusters. Here, we review the current knowledge on Sox gene family, their evolution and their functions.
The intensity of PLA2R and C4d immunoexpression in primary membranous nephropathy

Objective: Antibodies against the phospholipase A2 receptor (PLA2R) on podocyte membranes result in the formation of immune complexes that cause loss of function of the glomerular basement membrane in primary membranous nephropathy (PMN). It has also been demonstrated that there is a deposition of complement 4d (C4d) in the glomeruli in PMN. The present study aims to evaluate PLA2R and C4d immunoexpressions in PMN cases and search the correlation with the clinical parameters.
Triple and Quintuple Hops: Utility, Reliability, Asymmetry, and Relationship to Performance

ABSTRACT TRIPLE AND QUINTUPLE HOPS (THT AND QHT, RESPECTIVELY) ARE USED TO TEST REPEATED PROPULSION. THIS NARRATIVE REVIEW PROVIDES INFORMATION REGARDING THE USE OF THT AND QHT, AS WELL AS THEIR RELIABILITY, TESTING NORMS BY SEX AND ATHLETIC LEVEL, THEIR ABILITY IN DETECTING ASYMMETRY AND RELEVANCE TO OTHER PERFORMANCE MEASURES. THE TESTS' RELIABILITY (INTRACLASS CORRELATION COEFFICIENT [ICC]THT = 0.80–0.98; STANDARD ERROR OF THE MEAN [SEM]THT = 0.11–0.23 M; ICCQHT = 0.89) WARRANTS THEIR INCLUSION DURING TESTING BATTERIES. THT RANGES FROM 4.28 TO 6.90 M AND ASYMMETRIES RANGE FROM 10 TO 15%. THT IS LIKELY RELATED TO ACCELERATION CAPABILITIES. PRACTICAL RECOMMENDATIONS ARE PROVIDED TO PRACTITIONERS REGARDING TESTS' ADMINISTRATION.
Desenvolvimento de produtos ambientalmente sustentáveis: uma análise inicial de tendências a partir do método Delphi

Leandro Milano Yano (faculdade de engenharia de bauru ) leandroyano44@gmail.com Daniel Jugend (Faculdade de Engenharia de Bauru-Departamento de Engenharia de Produção ) daniel@feb.unesp. br VERUSKA MAZZA RODRIGUES DIAS (Faculdade de Engenharia de Bauru-Departamento de Engenharia de Produção ) veve_mazza@hotmail.com Wagner Colucci Izeppi (Faculdade de Engenharia de BauruDepartamento de Engenharia de Produção ) wagner_ci@hotmail.com Paulo Augusto Cauchick Miguel (Universidade Federal de Santa Catarina ) cauchick@usp.br
The Effect of Hinged Ankle-Foot Orthosis on Walking Function in Children With Spastic Diplegic Cerebral Palsy: A Cross-Sectional Pilot Study

Purpose: The aim of the current study was to examine the effects of hinged ankle-foot orthosis (HAFO) on walking function in children with spastic diplegic cerebral palsy (CP). Methods: Thirty-two children (mean age: 6.79±0.35 years, age range: 5-7 years) who were diagnosed with spastic diplegic cerebral palsy participated in the study. Each subject typically walked through 10 meters of a gait platform with markers on the subject's proper body segments and underwent 3-D motion analysis system with and without hinged ankle-foot orthosis. The HAFOs were all custom-made for individual CP children and had plantarflexion stop at 0° with no dorsiflexion stop. The interventions were conducted over three trials in each group, and measurements were performed on each subject by one examiner in three trials. 3-D motion analysis system was used to measure gait parameters such as walking velocity, cadence, step-length, step-width, stride-length, and double support period in two conditions. Results: The walking velocity, cadence, step-length, and stride-length were significantly greater for the HAFO condition as compared to the no HAFO condition (p<.05). However, no significant difference in step-width and double support period was observed between two conditions. Conclusion: These findings suggest that using the HAFO during walking would suggest positive evidence for improving the spatiotemporal parameters of gait in children with spastic diplegic cerebral palsy.
Oral Cancer: Etiology and Its Diagnostic Aids

Oral cancer is of major concern as it is southeast Asia primarily because of the prevalent oral habits of betel quid chewing, smoking, and alcohol consumption. Recent advances in diagnosis and therapeutic techniques of these lesions have yielded novel molecular targets, uncovered signal pathway dominance and advanced early cancer detection. This paper is an overview of the various etiological agents and risk factors implicated in the development of oral cancer and also diagnostic aids in oral cancer.
Heritage Languages: A Language Contact Approach

Heritage languages, such as the Turkish varieties spoken in Berlin or the Spanish used in Los Angeles, are non-dominant languages, often with little prestige. Their speakers also speak the dominant language of the country they live in. Often heritage languages undergo changes due to their special status. They have received a lot of scholarly attention and provide a link between academic concerns and educational issues. This book takes a language contact perspective: we consider heritage languages from the perspective of their history, their structural properties, and their interaction with other surrounding languages.
Research on the Construction Technology of Knowledge Graph in Aviation

In order to alleviate the overload of airspace information under the network environment and integrate the scattered and useful airspace information, the technical architecture of knowledge graph in the aviation field is proposed. This paper describes the technical architecture of aviation knowledge graph construction, including knowledge extraction, knowledge fusion, knowledge processing, knowledge update and other key technologies and applications. Finally, an instance of knowledge graph for air combat is constructed. The knowledge graph discovers the hidden relationship between task and maneuver through resource sharing and information mining, which can be used for mission optimization and maneuver prediction to assist air combat decision-making.
‘User-Home relationship’ regarding user experience of smart home products

ABSTRACT Technological developments in recent years have radically advanced the design of smart home products. With the help of artificial intelligence, the interaction between user and product has been raised to a new level. While AI has been changing the type of interaction, the relationships between user, product and home have gained importance to provide useful and meaningful outputs for smart home systems. This paper proposes a new approach by focusing on a specific relationship. The aim of the study is to explore the relationship between the user and the home to obtain insight into improving the user experience quality. The research explores specific characteristics such as home-occupancy status, home type and number of members of a household. This study consists of a literature review on the concept of smart home and a field study. The field study was conducted with 48 participants in the Bay Area, San Francisco. Following this, multiple-choice questionnaires and semi-structured interviews were conducted. With the findings of the study, the impact of the user-home relationship on the user experience of smart home products is discussed. We propose that this relationship should be taken into consideration as a new dynamic dimension for developing user experience strategies.
The role of microbiome in the formation of child health (literature review)

The review is devoted to the microbiome interactions with physiologic and pathologic processes that have place during child organism development. Modern data concerning the questions of the microbiome formation in children are examined, beginning from the intrauterine fetus development and further during the process of ontogenesis. Characteristics of the microbiota content and functional activity in infants are presented. Influence of changed microbiota on the disease development in the child age is described. Analysis of the data available is performed with appreciation of medicines used for the improvement of microbiome health at different forms of child pathology. No conflict of interest was declared by the authors.
Management, Triage and Outcomes of 378 Patients Presenting to the Emergency Department with Chest Pain of Acute Onset： A Single Centre Observational Study

Chest pain accounts for 700,000 hospital attendances in the UK each year. Prompt risk assessment and diagnosis both improves outcomes and reduces unnecessary admissions. Data on patients who presented to the ED with chest pain was collected retrospectively. Patients were then followed up via hospital records and telephone. 70% of the authors’ patients were triaged as low risk chest pain. Three represented within 30 d with non ischaemic chest pain. 1 patient had MACE. The authors’ triage pathway safely managed those presenting with chest pain.
Cross-Sectional survey to ascertain the prevalence of Molar Incisor Hypo-mineralization in the Trinidad and Tobago population

Aim: To determine the prevalence of molar incisor hypomineralization (MIH) in 11 to 12-year olds in the Trinidad and Tobago population and to determine if there is any association with ethnicity and gender. Design: Cross-sectional survey. Materials and Methods: First permanent molars and all permanent incisors were examined in 532 children comprising 317 females (58.1%) and 229 males (41.9%). The sample were 11-12 years olds (mean age 11.9 years) in high schools across Trinidad and Tobago. Examinations were conducted by one examiner. Results: Afro-Trinidadian subjects comprised 62% of the sample, Indo- Trinidadian subjects 22 % and Mixed ethnicity 16%. 7 out of 532 subjects had at least one molar with hypomineralization which represents overall prevalence of 1.3%. Maxillary molars were more frequently hypomineralized and females showed a higher prevalence than males. Conclusion: The prevalence of molar incisor hypomineralization in Trinidad and Tobago population was 1.3% in the 11-12 ears age group.
MHTyper: a microhaplotype allele-calling pipeline for use with next generation sequencing data

ABSTRACT Microhaplotypes have been reported for applications in different aspects of human forensics. Next generation sequencing (NGS) possesses several advantages in microhaplotype genotyping. Large amounts of NGS-based microhaplotype data has been accumulated, and bioinformatic software designed for microhaplotype NGS data analysis is in urgent need. In this work, we introduced MHTyper, a Linux/Unix pipeline designed for efficient microhaplotype allele-calling and sequencing depth statistics. We developed an NGS-based 30-plex microhaplotype panel and used MHTyper to analyse the data produced. The allele-calling accuracy of MHTyper was evaluated by manually comparing the MHTyper-reported genotypes with those visualized, along with the well-accepted bioinformatic software Integrative Genomics Viewer. No discordance was observed in all 150 pairs for comparison. These data supported that MHTyper could provide an efficient tool for NGS-based forensic microhaplotype data analysis.
How perceptions of residents toward assessment influence learning: A qualitative study

Any form of assessment activity will act as a stimulus and provoke an educational response. There is a risk however that the response will not result in a beneficial educational response, thus there is a need to monitor and understand the relationship between assessment and learning. This is true at any level of education including postgraduate medical education. To understand how residents perceived assessment, we interviewed 20 residents from the departments of internal medicine and paediatrics. Our goal was to determine how assessment influenced their motivation to accumulate knowledge and skills and attain the competence levels expected of a specialist. We utilised grounded theory to analyse the data. Our results showed that the trainees acknowledged that assessment, in general, has a positive influence on their learning, it motivated them to study and fostered an active learning attitude. A high degree of self-directed learning was also present among the residents. An interplay of new or interesting patient cases, concern for the welfare of the patients, engagement with the consultants, and a supportive environment contributed to creating the motivation for the residents to study.
Transitioning Trees from Traditional to Low-Water Landscapes

• A new plan for the landscape should be designed that clearly shows plants to be retained as well as those that will be removed. • Any new plants added near trees should be selected based on compatibility with the tree and its environment. Fig. 2. The mugo pine in this image needed less water than the (now dead) Japanese maple. Irrigation should have been managed to meet the greater water need of the maple.
Cheminformatics Analysis of Natural Product Scaffolds: Comparison of Scaffolds Produced by Animals, Plants, Fungi and Bacteria

Natural products (NPs) have evolved over a very long natural selection process to form optimal interactions with biologically relevant macromolecules. NPs are therefore an extremely useful source of inspiration for the design of new drugs. In the present study we report the results of a cheminformatics analysis of a large database of NP structures focusing on their scaffolds. First, general differences between NP scaffolds and scaffolds from synthetic molecules are discussed, followed by a comparison of the properties of scaffolds produced by different types of organisms. Scaffolds produced by plants are the most complex and those produced by bacteria differ in many structural features from scaffolds produced by other organisms. The results presented here may be used as a guidance in selection of scaffolds for the design of novel NP-like bioactive structures or NP-inspired libraries.
Tumor venéreo transmissível canino com resistência quimioterápica e metástase esplênica - Relato de caso

O Tumor Venéreo Transmissível Canino (TVTC) é uma neoplasia de células redondas que tem a particularidade de se implantar em mucosas que tenham perdido a sua integridade. Nesse local o tumor prolifera e ocasionalmente origina metástase. Em geral, o tumor responde ao tratamento com sulfato de vincristina, porém a resistência quimioterápica associada ao fenótipo tumoral tem sido documentada. Objetivou-se relatar um caso de TVTC genital de fenótipo citológico misto com metástase esplênica e o insucesso da quimioterapia com sulfato de vincristina, em uma fêmea canina, da raça Australian Cattle Dog, de cinco anos de idade. Após diagnóstico citológico e histológico, o tumor primário foi ainda caracterizado em fase de progressão e mostrou baixa expressão de moléculas do complexo principal de histocompatibilidade MHC (4,4 ± 2% classe I e 11 ± 4,1% classe II). A cadela foi submetida à ovariohisterectomia e esplenectomia terapêutica e não apresentou recidiva do tumor após 12 meses de acompanhamento clínico.