Miracle-dz/UniFAR-FTUs huggingface dataset:
Trends in female lifespan in South Korea, 1987–2016

South Korea shows a remarkable rapid increase in lifespan in recent decades. Employing a mathematical model that is appropriate for human survival curves, we evaluate current trends in female lifespan for South Korea over three recent decades, 1987–2016, and predict coming trends in female lifespan until 2030. From comparative analyses with industrialized countries such as Japan, France, Australia, Switzerland, UK, Sweden, and USA, we confirm that South Korea has the highest increase rate of female lifespan in recent decades, and estimate that maximum lifespan would reach 125 years and characteristic life would surpass 95 years for South Korean female by 2030. South Korea would deserve much attention in study on human health and longevity as the longest-lived country in coming decades.
Genetic diversity among walleye (Sander vitreus) populations in inland Ontario: Relationships with life history traits.

This thesis focuses on the relationships between genetic diversity, environmental parameters, and fitness in walleye {Sander vitreus: Percidae), as well as the influences of natural and anthropogenic factors on walleye population structure across the province of Ontario. 11 selectively neutral microsatellite DNA loci were used to characterize the genetic diversity and population structure of 46 populations of walleye. Genetic diversity estimates (observed heterozygosity (Ho), mean square allelic distance (d^), and Wright’s inbreeding coefficient (Fis)) revealed high levels of genetic diversity. The relationships observed between lake parameters and population genetic diversity revealed positive relationships between lake surface area, growing degree days, number of species, and hatchery supplementation versus H q and d . ̂ The only significant positive correlation observed between life history traits and genetic diversity was early growth rate versus H q for male and female walleye. The relationship between Fis and male early growth rate was significant (p < 0 .0 1 ) and marginally non significant for females (p= 0.06), and both relationships had negative slopes, indicative of inbreeding effects. No significant relationships were observed for d ̂with any life history trait. A moderate level of population differentiation (Fst = 0.155, 95% Cl 0.125 0.185) exists among the 46 walleye populations. AMO VA revealed that among populations, the variance explained by within primary drainage basins (14.3 %) was more than 10 times of the variance explained by among drainage basins (1.2 %). Neighbour-joining cluster analysis did not show strong clustering of populations within drainage basins, but it did show a distinct pattern of population division into northern vs. southern clades. Geographic patterning of differentiation among four of the five primary drainage basins could not be
Phagocyte apoptosis in innate immunity: Initiation by bacterial phagocytosis and modulation by B-cell lymphoma-2 (Bcl-2) family members

The apoptosis of phagocytes strongly affects course and termination of responses of the innate immune system during infection. This work identified phagocytosis and the intracellular degradation of bacteria as an important factor in the initiation of macrophage apoptosis. In the termination phase of the immune response, granulocyte apoptosis plays a critical role, and the involvement of the Bcl-2 proteins Bim, Puma, and A1 in cell death could be shown. It was further demonstrated that activated immune functions of neutrophils can only be shut off through apoptosis. Accordingly, in a murine model of pneumococcal meningitis, a block of apoptosis led to hyperinflammation and aggravated the course of the disease.
The neoliberal reality of higher education in Australia: how accountingisation is corporatising knowledge

Purpose As accounting academics, the authors know that performance measurement is well-trodden ground in the literature. Yet rarely have they turned their gaze inwards to examine the performance controls which they are subject to in the own everyday working life. Over the past 40 years, the rise of the New Public Management paradigm and neoliberalism has intensified changes in the way universities, disciplines and individual academics justify the quality of their work. This paper aims to explore the impact of accountingisation on the field and the Australian public sector higher education sector. Design/methodology/approach The perceptions of accounting academics in Australia’s 37 business faculties and schools were collected via an online survey. Additionally, a document analysis of annual reports, internal reports, strategy documents and other confidential material were also used. Findings The changes have included the use of corporate and individual research metrics aimed at increasing institutional status, brand reputation and revenue generation. These changes have transformed business schools and universities into commercial enterprises and commoditised education. What this analysis demonstrates is the apparent relationship between various government agendas, the commercialisation of universities and the distortion of the research activities by individual academics. For increased profits and efficiencies, individual scholars have paid the highest price. Practical implications If the accounting discipline is to be sustainable in the long term, business schools in Australia must reconfigure their performance measurement systems. Originality/value To date, research on “accountingisation” has previously been primarily conducted in the health and social services sectors. This research raises rarely heard voices to expose the actual social and human costs of accountingisation in Australia’s higher education sector.
Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1

Main mitotic kinases as PLK1 are activated at the S/G2 transition. A change in Cyclin A2 localisation at the S/G2 transition enables activation of PLK1. Cyclin A2 is a key regulator of the cell cycle, implicated both in DNA replication and mitotic entry. Cyclin A2 participates in feedback loops that activate mitotic kinases in G2 phase, but why active Cyclin A2-CDK2 during the S phase does not trigger mitotic kinase activation remains unclear. Here, we describe a change in localisation of Cyclin A2 from being only nuclear to both nuclear and cytoplasmic at the S/G2 border. We find that Cyclin A2-CDK2 can activate the mitotic kinase PLK1 through phosphorylation of Bora, and that only cytoplasmic Cyclin A2 interacts with Bora and PLK1. Expression of predominately cytoplasmic Cyclin A2 or phospho-mimicking PLK1 T210D can partially rescue a G2 arrest caused by Cyclin A2 depletion. Cytoplasmic presence of Cyclin A2 is restricted by p21, in particular after DNA damage. Cyclin A2 chromatin association during DNA replication and additional mechanisms contribute to Cyclin A2 localisation change in the G2 phase. We find no evidence that such mechanisms involve G2 feedback loops and suggest that cytoplasmic appearance of Cyclin A2 at the S/G2 transition functions as a trigger for mitotic kinase activation.
Chromosome analysis of tea plant (Camellia sinensis) and ornamental camellia (Camellia japonica)

Chromosome analysis of tea plant (Camellia sinensis), an important commercial crop used to prepare beverages throughout the world, was conducted using fluorescence in situ hybridization (FISH) and chromosome image analyzing system IV (CHIAS IV) software. Chromosomes of C. japonica, a popular woody plant used as an ornamental tree and an important breeding resource for tea plants, were used for comparison with C. sinensis. Both C. sinensis and C. japonica comprised 30 chromosomes. The 5S rDNA, a fundamental repeat sequence and a landmark for FISH, was used for Camellia karyotyping. We observed one 5S rDNA locus on two chromosomes in both the species and confirmed the presence of bivalents in the meiotic cells of interspecific hybrids between C. japonica and C. sinensis. These results suggest that the two species have homoeologous chromosomes. C. sinensis chromosomes were analyzed using CHIAS IV, which performs quantitative karyotyping. This is the first report on the karyotyping of the Japanese tea plant C. sinensis by FISH and quantitative image analysis using CHIAS IV. This report will accelerate the use of cytological and genetic linkage map analysis in tea breeding.
DNA methylation dynamics during embryonic development and postnatal maturation of the mouse auditory organ of Corti

Background The mammalian inner ear is a complex morphological structure responsible for hearing and balance, and its pathology is associated with deafness and balance disorders. To evaluate the role of epigenomic dynamics in the development and maturation of mouse inner ear sensory epithelium, we performed whole-genome bisulfite sequencing on inner ear tissue, yielding temporal base-pair resolution methylomes at key developmental time points. Results We found a late accumulation of non-CpG methylation, indicating a similarity between the inner ear sensory epithelium and neuronal tissue. Moreover, annotation of both unmethylated and low methylated regions pointed to regulatory elements active in the inner ear in proximity of and distal from transcriptional units. Finally, we identified differentially methylated regions across the transition periods. An analysis of these regions led us to identify several novel candidate regulatory factors, connecting regulatory elements from specific time points in development to molecular features that drive the development and maturation of the inner ear sensory epithelium. The GJB6 locus putative regulatory region was shown to upregulate distal GJB6 gene expression and a non-coding RNA. Conclusions Our analysis of inner ear sensory epithelium DNA methylation sheds light on novel regulatory regions in the hearing organ, and may help boost diagnostic capabilities and guide the development of therapeutics for hearing loss, by providing multiple intervention points for manipulation of the auditory system.
A Stacked Deep Learning Approach for IoT Cyberattack Detection

Internet of things (IoT) devices and applications are dramatically increasing worldwide, resulting in more cybersecurity challenges. Among these challenges are malicious activities that target IoT devices and cause serious damage, such as data leakage, phishing and spamming campaigns, distributed denial-of-service (DDoS) attacks, and security breaches. In this paper, a stacked deep learning method is proposed to detect malicious traffic data, particularly malicious attacks targeting IoT devices. The proposed stacked deep learning method is bundled with five pretrained residual networks (ResNets) to deeply learn the characteristics of the suspicious activities and distinguish them from normal traffic. Each pretrained ResNet model consists of 10 residual blocks. We used two large datasets to evaluate the performance of our detection method. We investigated two heterogeneous IoT environments to make our approach deployable in any IoT setting. Our proposed method has the ability to distinguish between benign and malicious traffic data and detect most IoT attacks. The experimental results show that our proposed stacked deep learning method can provide a higher detection rate in real time compared with existing classification techniques.
Evolution and Functional Information

“Functional Information”—estimated from the mutual information of protein sequence alignments—has been proposed as a reliable way of estimating the number of proteins with a specified function and the consequent difficulty of evolving a new function. The fantastic rarity of functional proteins computed by this approach emboldens some to argue that evolution is impossible. Random searches, it seems, would have no hope of finding new functions. Here, we use simulations to demonstrate that sequence alignments are a poor estimate functional information. The mutual information of sequence alignments fantastically underestimates of the true number of functional proteins, because it also is strongly influenced by a family’s history, mutational bias, and selection. Regardless, even if functional information could be reliably calculated, it tells us nothing about the difficulty of evolving new functions, because it does not estimate the distance between a new function and existing functions. The pervasive observation of multifunctional proteins suggests that functions are actually ver close to one another and abundant. Multifunctional proteins would be impossible if the FI argument against evolution were true.
Exploring the use of goal proximity by Olympic athletes: A preliminary study

An athlete’s 4-year Olympic preparation cycle requires systematic planning involving the use of shortand long-term goals. These goals provide athletes with increased motivation, persistence, effort and direction in their goal pursuit. Short-term goals can be viewed as steppingstones towards the long-term goals. Therefore, the purpose of this study was to explore the use of shortand long-term goals by Olympic athletes. A qualitative design was used, with semi-structured interviews as the major data source. Participants were purposefully sampled from a typically understudied sports population. Four male Olympians, representing swimming and athletics, shared their experiences about how and why they set and used shortand long-term goals. The athletes spent an average of 11.3 years training and competing at the elite level. Findings revealed that winning a national championship and competing at the Olympic Games were their major long-term goals. Furthermore, these goals did not change during their athletic career. Short-term goals were primarily set to learn, develop and improve their skills/techniques that would allow them to reach their ultimate goals. Major competitive events (e.g. national championships, Pan Am Games, Olympic Games) dictated how they planned these goals. The findings also support previous research suggesting the use of both short and long-term goals. Coaches and young athletes can use the information provided to plan their sports goals. Future research should investigate the goal setting practices of team versus individual sport Olympic athletes.
EFFECTS OF PRIVATE SECURITY COMPANIES ON ENHANCEMENT OF PUBLIC SECURITY AND SAFETY IN DAR ES SALAAM, TANZANIA: CASE STUDY OF ILALA MUNICIPALITY

Worldwide, countries have showing great consideration on crime control and prevention within the community for the purpose of enhancing public security. Governments, or public law enforcement agencies - individuals, communities, non-governmental organizations, civil society and the private sectors have all played a role in enhancing security and community safety. The study aims to determine the perceptions of the clients towards Private Security Companies have their role in terms of providing public security and safety, to explore the attitudes of the Tanzania police force towards the Private Security Companies in IIala Municipal. The study adopted descriptive research design, the study used Slovene's Formula to obtain a sample size of 205 respondents from the target population for this study constituted of 2 private security companies (MKB and MOKU), 270 security guards, 80 clients, and 70 Police officers making 420 in a total, structured questionnaire was used to collect primary data, data was analyzed using a descriptive statistic, the study concluded that Tanzania police need to continue to work in collaboration with PSCs to combat crime in promoting public safety and there was A good link between TPF and PSC in promoting public security in Tanzania. The study recommended that PSCs and police need to strengthen especially in areas of investigation of crime, training of security companies, registration of these companies and the process needed to acquire firearms and other security-related equipment that needed in promoting Public security also the study recommended that further study should be conducted concerning rules and policy governing private security company operations in Tanzania.
Etude biochimique, biophysique et structurale du mécanisme d'action et de l'inhibition sélective de l'histone désacétylase HDAC8

Les histones desacetylases (HDACs) sont les principales cibles des medicaments epigenetiques anticancereux actuellement approuves par la FDA. Les HDACs jouent aussi un role important dans l'homeostasie des pathogenes eucaryotes. Par consequent, une strategie pour lutter contre les maladies negligees causees par ces pathogenes est de modifier les medicaments epigenetiques actuellement approuves qui ciblent les HDACs. HDAC8 de Schistosoma mansoni (smHDAC8) est une cible medicamenteuse valable pour traiter la schistosomiase, deuxieme maladie negligee mortelle apres le paludisme. Les differences structurales entre les poches catalytiques des HDAC8 humaine et smHDAC8 ont permis la conception d'inhibiteurs selectifs des schistosomes qui se lient dans une poche selective unique a HDAC8. Ce travail de these montre comment cibler selectivement des isoformes HDAC l'aide de structures a resolution atomique, et ouvre la porte a l'etude du mode d'action de HDAC8 au niveau fondamental.
Effects of perceived predation risk on extra-pair mating in blue tits (Cyanistes caeruleus)

Teaching Since 2014 University of Bergen (25% teaching): Ecology, Evolutionary Biology, Parasitology (Department of Biological Sciences) Evolutionary theory, Darwin’s biography (Centre for Women and Gender Research) 2012-2014 University of Amiens (Associate Professor), >200h of classroom presence / year: Ecology (course coordinator), developed from scratch incl. field and lab courses Evolutionary Biology, Parasitology, and Behavioural Ecology 2010 University of Bergen (voluntary teaching, 2 weeks): Advanced Topics in Ecology and Evolution 2004-2008 University of Montpellier (teaching assistant, lab courses & tutorials, 100h / year): Zoology, botany, developmental biology, reproduction biology, phylogeny Education
CARCASS AND MEAT QUALITY IN RELATION TO THE POLYMORPHISM IN PORCINE MYF4 GENE

The aim of this study was to analyse the associations between polymorphism in porcine myogenin gene (MYF4) and economically important traits in relation to the carcass and meat quality of pigs. The genomic DNA samples were taken from in total 180 crossbreeds (Large White x Landrace). The detection of polymorphism in MYF4 gene were performed in order to evaluate its effect on back fat thickness, proportion of valuable meat parts, MLT area and proportion of thigh. The genotyping of analysed individuals was carried out by means PCR-RFLP method and restriction endonuclease MspI. The allele frequencies were as follows: A 0.75 and B 0.25. A prevalence of AA genotype (59%) compared to AB (33%) and BB genotypes (8%) were detected in analysed crossbreed population. The observed average value of heterozygosity (0.33) and positive value of the Wright's FIS index (0.12) similarly reflected the higher proportion of homozygous genotype in populations. The effect of MYF4 gene polymorphism on selected phenotypic traits has been tested using one-way ANOVA procedure. The statistical analysis showed only non-significant results. Due to the polygenic character of selected phenotypic traits the involvement of other candidate genes and increase of sample size could clarify the role of MYF4 gene in porcine carcass and meat quality regulation. The study, which is based on molecular variability of livestock genetic resources, is necessary for the genetic improvement and understanding of relations between markers and trait of interest.
The synergism of B and T lymphocyte attenuator (BTLA) and cytotoxic T lymphocyte associated antigen-4 (CTLA-4) attenuated acute T-cell mediated rejection and prolonged renal graft survival

Background Acute T-cell mediated rejection (TCMR) continues to be a major problem in the area of kidney transplantation. The B and T lymphocyte attenuator (BTLA) and cytotoxic T lymphocyte associated antigen-4 (CTLA-4) were recently found costimulatory molecules. The research aims to explore the inhibitory synergism of BTLA and CTLA-4 in TCMR. Methods We investigated the suppressive role of overexpressed BTLA and CTLA-4 in vitro. The rat kidney transplantation model was established to explore the effect of combined overexpressed BTLA and CTLA-4 in recipients of kidney transplantation. The grafts and peripheral blood were harvested for renal function, histology, immunohistochemical and flow cytometry analysis. Results Combination therapy decreased the secretion of interleukin-2 (IL-2) and proliferation of T cells compared to the single therapy and the control group. Decrease of interstitium monocyte infiltration and especially intimal arteritis in the graft was observed with the combination therapy, with remarkable reduction of numbers and proliferation response of T cells in peripheral blood and grafts. Combined overexpressed BTLA and CTLA-4 attenuated the acute TCMR after kidney transplantation and improved the graft function and prolonged the graft survival. The inhibiting role against TCMR in the combination therapy group was more effective than single therapy. Conclusions The synergism of BTLA and CTLA-4 attenuated acute TCMR after kidney transplantation by suppressing T cell activation and proliferation.
Feeding Forage in Poultry: A Promising Alternative for the Future of Production Systems

The present review discusses the existing research findings on the nutritional impact of forages in poultry diet and the significance of forages in sustainable poultry production systems. The nutritional composition and antinutritional factors of the main forages and the pros and cons of feeding forage on poultry meat and egg quality under free-range and organic production systems are also discussed. This review highlights the importance of forages and forage meals in poultry ration, considering that these feedstuffs may have greater value to the success of local poultry production in many regions of the world due to their potential of production.
Evaluating the toxicological effects of agrochemicals on glucocorticoid receptor and serum cortisol level in Mozambique tilapia

Abstract The agricultural sector is considered to be the backbone of a countries economy. To increase the crop yield, there is an extensive use of agrochemicals in the form of insecticides, herbicides, nutrient mixture, fungicides, etc. This is necessarily involved in controlling the unwanted organisms; however, it leads to toxicity in a nearby ecosystem. Aquatic habitats being a complexed ecosystem are distressed with the increasing concentration of agrochemicals, which leads to an alteration in nontarget species at various trophic levels. Fishes are considered to be the dynamic players of this ecosystem and are the first one to be acquainted with any contaminants present in it. In this context, the present study was aimed to find the sublethal effects (1/10th of the LC50 value) of four different agrochemicals (imidacloprid—insecticide, pyrazosulfuron ethyl—herbicide, curzate—fungicide and micronutrient mixture) on the stress physiology of Oreochromis mossambicus. The hormonal titer of cortisol and gene expression of its receptor was carried out to understand the toxicity of diverse agrochemicals. The results suggested that there was a significant decrease in hormonal titer of cortisol upon the exposure of curzate and imidacloprid, with a significant downregulation of glucocorticoid receptor under the exposure of imidacloprid. Thus, the novel findings suggest that fishes were found to be devoid of stress response which may be due to hypothalamus pituitary interrenal exhaustion.