Miracle-dz/UniFAR-FTUs huggingface dataset:
Invariant eigendistributions on semisimple Lie groups

1. Let M be an oriented separable differentiable manifold of dimension n. (We do not assume that M is connected.) Let C*(M) denote the space of all complex-valued C functions on M with compact support. A distribution T on M is a linear mapping T: CTM(M)-*C which is continuous in the topology of Schwartz. More explicitly, this means the following. Let U be any open and relatively compact set in M. Then we can select differential operators Di9 • • • , Dr on M such that In/)I ^ZsupiA/i a€cT(to).
Recovery of parathyroid function after total thyroidectomy: Long‐term follow‐up study

Background: To prevent postoperative hypoparathyroidism following total thyroidectomy, the parathyroid glands are preserved in situ and/or resected or devascularized parathyroid glands are autotransplanted. A retrospective investigation was conducted utilizing biochemical and specific endocrine assessments to evaluate the difference in recovery of parathyroid function in the long term.
C-kit Expression of Melanocytic Neoplasm and Association With Clinicopathological Parameters and Anatomic Locations in Chinese People

Abstract:Distinct genetic aberrations between melanomas in different anatomical locations have been confirmed in recent years. However, the associations between immunohistochemical expression, tumor sites, and clinical parameters are not clear. We examined the correlation of protein expression and gene mutation of c-kit with clinicopathological parameters and lesion locations in patients with malignant melanoma (MM). We collected 170 melanocytic lesions, including 106 cutaneous MM from acral melanoma (AM) and nonacral melanoma (NAM) sites, 24 dysplastic nevi, and 40 common melanocytic nevi. Tissue microarray was constructed, and immunohistochemical expression for c-kit was assessed with correlation with clinical parameters. Mutation in exons 11, 13, 17, and 18 of KIT gene in genomic DNA by polymerase chain reaction sequencing was also analyzed. Immunostaining scores for c-kit were found to be statistically higher in Dysplastic Nevi than in common melanocytic nevi and MM. In addition, cytoplasmic c-kit staining was significantly correlated with poor survival in patients with AM but not in those with NAM. Twenty-nine cases of MM (including 9 NAM and 20 AM) are analyzed for mutation in exons 11, 13, 17, and 18 of KIT gene in genomic DNA by polymerase chain reaction sequencing, and no genetic mutation is found. Our findings confirm that KIT mutations, in contrast to previous white cohorts, are not common in both AM and NAM of the Chinese and do not necessarily correlate with c-kit expression. The significantly different association between the expression of c-kit immunoreactivities and the mortality risks of melanomas on acral versus nonacral sites might change site-specific targeted therapeutic concepts in melanoma in the future.
Endocrine effects of alcohol.

A variety of effects of alcohol on endocrine function are now well documented. Clinically, the most important of these are alcohol-induced 'pseudo-Cushing's syndrome' and a syndrome of hypothalamic-pituitary-adrenocortical unresponsiveness, both of which result from long-term over-indulgence, and impairment of testosterone secretion which may occur following relatively short-term drinking. Evidence indicates that a number of different mechanisms are responsible for mediating the effects of alcohol on endocrine function. In a few instances (e.g. inhibition of vasopressin secretion and impairment of steroidogenesis resulting in a fall in testosterone production rate), alcohol appears to influence directly the release or synthesis of individual hormones. However, the majority of the endocrine effects of alcohol are probably indirect, resulting from either the stress of intoxication (stimulation of cortisol, catecholamines and possibly GH and prolactin), changes in the level of intermediary metabolites (e.g. a fall in circulating FFA stimulating GH secretion) or changes in the metabolism of hormones (e.g. catecholamines, oestrogens, androgens) resulting from alteration in intracellular redox state or tissue damage.
Justice Orientation as a Moderator of the Framing Effect on Procedural Justice Perception

ABSTRACT Justice orientation is a justice-relevant personality trait, which is referred to as the tendency to attend to fairness issues and to internalize justice as a moral virtue. This study examined the moderating role of justice orientation in the relationship between justice perception and response to a decision problem. The authors manipulated procedural justice and the outcome valence of the decision frame within a vignette, and measured justice orientation of 174 Japanese participants. As hypothesized, the results indicated an interaction between procedural justice and framing manipulation, which was moderated by individual differences in justice orientation. In negative framing, justice effects were larger for individuals with high rather than low justice orientation. The results are explained from a social justice perspective, and the contributions and limitations of this study are also discussed with respect to our sample and framing manipulation.
Aging A Natural History

Thank you very much for downloading aging a natural history. Maybe you have knowledge that, people have search numerous times for their chosen readings like this aging a natural history, but end up in harmful downloads. Rather than enjoying a good book with a cup of coffee in the afternoon, instead they cope with some infectious bugs inside their desktop computer. aging a natural history is available in our book collection an online access to it is set as public so you can get it instantly. Our digital library saves in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Merely said, the aging a natural history is universally compatible with any devices to read.
Fitspiration on Instagram: Identifying Topic Clusters in User Comments to Posts with Objectification Features

ABSTRACT This study aimed to examine features of objectified images in popular fitspiration accounts on social media, identify the most prevalent user discussion topics about these images, and investigate the linkages between specific objectification cues and discussion topics. We employed content analysis to identify gender-specific objectification elements in fitspiration images (N = 2,000) on Instagram and unsupervised topic modeling to uncover topics in user comments (N = 35,263). Multilevel regressions were conducted to examine how gender and objectification features associate with the topics. Results revealed that one-third of the images were objectified. Objectification features such as sexual posing and the presence of objectified chest or abdomen were associated with the occurrence of two out of the three most prominent topic clusters (inspiration, body, and image-related discussions). We concluded that objectified fitspiration may distract users from health goals.
Supporting Clinical Cognition: A Human-Centered Approach to a Novel ICU Information Visualization Dashboard

Advances in intensive care unit bedside displays/interfaces and electronic medical record (EMR) technology have not adequately addressed the topic of visual clarity of patient data/information to further reduce cognitive load during clinical decision-making. We responded to these challenges with a human-centered approach to designing and testing a decision-support tool: MIVA 2.0 (Medical Information Visualization Assistant, v.2). Envisioned as an EMR visualization dashboard to support rapid analysis of real-time clinical data-trends, our primary goal originated from a clinical requirement to reduce cognitive overload. In the study, a convenience sample of 12 participants were recruited, in which quantitative and qualitative measures were used to compare MIVA 2.0 with ICU paper medical-charts, using time-on-task, post-test questionnaires, and interviews. Findings demonstrated a significant difference in speed and accuracy with the use of MIVA 2.0. Qualitative outcomes concurred, with participants acknowledging the potential impact of MIVA 2.0 for reducing cognitive load and enabling more accurate and quicker decision-making.
Estimating the Return-on-Investment From Changes in Employee Health Risks on The Dow Chemical Company's Health Care Costs

Objective: We sought to estimate the impact of corporate health-management and risk-reduction programs for The Dow Chemical Company by using a prospective return-on-investment (ROI) model. Methods: The risk and expenditure estimates were derived from multiple regression analyses showing relationships between worker demographics, health risks, and medical expenditures. Results: A “break-even” scenario would require Dow to reduce each of 10 population health risks by 0.17% points per year over the course of 10 years. More successful efforts at reducing health risks in the population would produce a more significant ROI for the company. Conclusions: Findings from this study were incorporated into other components of a business case for health and productivity management, and these supported continued investments in health improvement programs designed to achieve risk reduction and cost savings.
Energy conscious scheduling with controlled threshold for precedence-constrained tasks on heterogeneous clusters

Efficient task scheduling of concurrent tasks is one of the primary requirements for high-performance computing platforms. Recent advances in high-performance computing have resulted in widespread performance improvement though at the cost of increased energy consumption and other system resources. In this article, an energy conscious scheduling algorithm with controlled threshold has been developed for precedence-constrained tasks on heterogeneous cluster, which aims at lower makespan along with reduced energy consumption. Energy conscious scheduling with controlled threshold algorithm combines the benefits of dynamic voltage scaling with controlled threshold-based duplication strategy to achieve its objectives. Effectiveness of the proposed algorithm is analyzed in comparison with available duplication- and non-duplication-based scheduling algorithms (with and without dynamic voltage scaling approach) to ascertain its performance and energy consumption. Exhaustive simulation results on random and real-world graphs demonstrate that energy conscious scheduling algorithm with controlled threshold has the potential to reduce energy consumption and makespan.
Amenorreia em atletas: revisão da literatura / Amenorrhea in athletes: literature review

A pratica de atividades fisicas feita por mulheres no menacme, visando excelencia competitiva, pode levar a diversas alteracoes no ciclo menstrual ate mesmo com a suspensao da menstruacao. No presente artigo, pretendeu-se avaliar o efeito da pratica excessiva de exercicios realizados pelas mulheres atletas em relacao a disturbios menstruais e a amenorreia, atraves de revisao da literatura. Para obter uma analise atual sobre o tema, foi realizada uma revisao bibliografica sistematica dos trabalhos publicados e inseridos dos bancos de dados PUBMED, LILACS e SCIELO, cruzando as palavras chave “amenorreia” e “atleta”, no periodo de 2011 a maio de 2016. Como resultado, foram aqui descritos 13 artigos que trazem um panorama das ultimas atualizacoes sobre o tema. Descritores : Atletas, Amenorreia, Esportes, Ciclo menstrual, Disturbios menstruais
Rôle de la SIRT3 et de la déacétylation des protéines mitochondriales dans la cardioprotection : effet du vieillissement

L'infarctus du myocarde est une des premiere cause de mortalite mondiale et l'amelioration de la prise en charge et des techniques de reperfusion ont permis une amelioration de la survie des patients. Les methodes de cardioprotection se sont developpees afin de limiter la taille d'infarctus apres l'episode d'ischemie reperfusion dans le but de limiter les effets deleteres de l'infarctus du myocarde, tels que le remodelage ventriculaire et l'insuffisance cardiaque.Dans notre etude, nous nous sommes particulierement focalises sur le role majeur de la mitochondrie dans les phenomenes de mort cellulaire associes a l'ischemie reperfusion. Au sein de la mitochondrie, notre cible principale etait la sirtuine 3 (SIRT3), dont les modifications post-traductionnelles associees ont ete montrees comme ayant un role potentiel dans la modulation de la mort cellulaire liee a l'ischemie reperfusion. Ainsi, dans la premiere partie de notre travail, nous avons pu mettre en evidence (1) la necessite de la SIRT3 dans les mecanismes de cardioprotection chez les souris jeunes et (2) l'importance de la deacetylation par la SIRT3 de la cyclophiline D (CypD) dans la reussite de la cardioprotection.Recemment, de nombreuses etudes precliniques ont mis en avant de nouvelles techniques de cardioprotection efficace chez differents modeles animaux, qui n'ont pourtant pas fait leur preuve lors de la transposition en etude clinique. Dans une seconde partie de notre travail, nous nous sommes attaches a comprendre une des raisons de ces differents echec cliniques, en nous appuyant sur le simple constat que les etudes precliniques sont realisees sur des animaux jeunes, alors que l'infarctus du myocarde est une pathologie des personnes senescentes. Nous avons ainsi etudie l'impact du vieillissement sur differentes methodes de cardioprotection utilisees au laboratoire, et avons mis en evidence (3) des modifications mitochondriales impactant la deacetylation de la CypD en reponse aux techniques de cardioprotection chez les souris âgees. Cette etude nous a permis de soulever un probleme majeur des etudes precliniques, a savoir l'âge des modeles animaux utilises par rapport a la pathologie etudiee.Ce travail a donc permis de determiner le role crucial de la deacetylation de la CypD et de la SIRT3 dans la cardioprotection, mais aussi de soulever la question de l'âge des modeles animaux avant de possibles transferts des avancees therapeutiques en clinique humaine
The Vasopressor Response to Centrally Administered Ouabain

Ouabain (80 γgAg) injected into the lateral cerebroventricles (ICV) of rats produced a prompt and sustained increase in arterial blood pressure. A diastolic blood pressure increase of about 40 mm Hg began within 10 minutes of injection and lasted at least 1 hour. This dose of ouabain had no effect on arterial pressure when given intravenously. The vasopressor response to intracerebroventricularly administered ouabain was not blocked by prior intravenous administration of phentolamine (1 γg/kg) or hexamethonium (3 mg/kg). However, continuous intravenous infusion of saralasin (2 mg/kg per min) prevented the pressor response to intracerebroventricularly administered ouabain. In addition, bilateral nephrectomy, adrenalectomy, pretreatment with intravenously administered propranolol (2 mg/kg) or captopril (10 mg/kg) abolished the increase in blood pressure evoked by intracerebroventricularly administered ouabain. Plasma renin and epinephrine levels at the peak of the pressor response to intracerebroventricularly administered ouabain were respectively, about 2.5- and 2-fold higher than in control rats. Our data indicate that ouabain administered into the central nervous system produces a hypertensive effect which does not primarily involve peripheral α-adrenergic receptors, but appears to be due to angiotensin II produced by renin of renal origin. These data suggest that digitalis agents can interact with sites in the central nervous system to induce a release of renin from the kidney; this release appears to involve activation of β-adrenergic receptors by catecholamines from the adrenal medulla, perhaps through a direct adrenal-kidney vascular network.
Clues from Xanthomonas campestris about the evolution of aromatic biosynthesis and its regulation.

The recent placement of major Gram-negative prokaryotes (Superfamily B) on a phylogenetic tree (including, e.g., lineages leading to Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter calcoaceticus) has allowed initial insights into the evolution of the biochemical pathway for aromatic amino acid biosynthesis and its regulation to be obtained. Within this prokaryote grouping, Xanthomonas campestris ATCC 12612 (a representative of the Group V pseudomonads) has played a key role in facilitating deductions about the major evolutionary events that shaped the character of aromatic biosynthesis within this grouping. X. campestris is like P. aeruginosa (and unlike E. coli) in its possession of dual flow routes to both L-phenylalanine and L-tyrosine from prephenate. Like all other members of Superfamily B, X. campestris possesses a bifunctional P-protein bearing the activities of both chorismate mutase and prephenate dehydratase. We have found an unregulated arogenate dehydratase similar to that of P. aeruginosa in X. campestris. We separated the two tyrosine-branch dehydrogenase activities (prephenate dehydrogenase and arogenate dehydrogenase); this marks the first time this has been accomplished in an organism in which these two activities coexist. Superfamily B organisms possess 3-deoxy-D-arabino-heptulosonate 7-P (DAHP) synthase as three isozymes (e.g., in E. coli), as two isozymes (e.g., in P. aeruginosa), or as one enzyme (in X. campestris). The two-isozyme system has been deduced to correspond to the ancestral state of Superfamily B. Thus, E. coli has gained an isozyme, whereas X. campestris has lost one. We conclude that the single, chorismate-sensitive DAHP synthase enzyme of X. campestris is evolutionarily related to the tryptophan-sensitive DAHP synthase present throughout the rest of Superfamily B. In X. campestris, arogenate dehydrogenase, prephenate dehydrogenase, the P-protein, chorismate mutase-F, anthranilate synthase, and DAHP synthase are all allosteric proteins; we compared their regulatory properties with those of enzymes of other Superfamily B members with respect to the evolution of regulatory properties. The network of sequentially operating circuits of allosteric control that exists for feedback regulation of overall carbon flow through the aromatic pathway in X. campestris is thus far unique in nature.
[Association between ambient air pollution and stroke mortality in Wuhan, China: A time-series analysis].

OBJECTIVE Using time-series analyses to determine the association between ambient air pollution and stroke mortality in Jiang'an District of Wuhan, China from 2003 to 2010. METHODS Data on daily stroke mortality for the period 2003 January 1 to 2010 December 31 was obtained from Jiang'an District Center for Disease Control and Prevention, Wuhan and data on relevant air pollution and meteorological factors from the local municipal environmental monitoring center and meteorology bureau of Wuhan, respectively. Application of a time-series analysis in generalized additive model was applied to evaluate the association between air pollution and stroke mortality. RESULTS Annual average concentrations of PM10, SO(2) and NO(2) during the study period were (115.0 ± 60.0), (50.2 ± 33.7), and (57.6 ± 25.3) µg/m³ respectively. The total stroke death was 9 204, including 4 495 women, and 7 628 people aged over 65-years old. In single-pollutant model, a 10 µg/m³ increase in previous day (lag 1 d) ambient pollutants was associated with 0.67% (95% CI: 0.25%-1.10%) excess risk in stroke mortality for PM10, 0.87% (95% CI: 0.13%-1.63%) excess risk for SO(2) and 2.07% (95% CI: 1.08%-3.07%) excess risk for NO(2), respectively. When co-pollutants were involved into the models, only NO(2) remained strongly associated with stroke mortality (β = 2.07, 95% CI: 1.08-3.07, P < 0.001). A 10 µg/m³, increase of NO(2) in lag 1 d was associated with 1.77% (95% CI: 0.54%-3.01%), 2.27% (95% CI: 0.98%-3.57%) and 2.00% (95% CI: 0.59%-3.43%) excess risk in stroke mortality, respectively, after adjusting for PM10, SO(2)th PM10 and SO(2) e-specific and gender-specific analyses showed that the association between ambient air pollution and stroke mortality was stronger in the elderly (≥ 65 years old) people and women. A 10 µg/m, increase of PM10, SO(2) NO(2) in lag 1 d was associated with excess stroke mortality of 0.97% (95% CI: 0.37%-1.57%), 1.73% (95% CI: 0.69%-2.78%) and 2.98% (95% CI: 1.59%-4.39%) for women, respectively and 0.94% (95% CI: 0.47%-1.42%), 1.06% (95% CI: 0.23%-1.90%) and 2.50% (95% CI: 1.40%-3.62%) for the elderly people (> 65 years old), respectively. CONCLUSION PM10 and gaseous pollutants (SO(2), NO(2)) were significant risk factors for acute stroke death, and people aged over 65-years old and women were more susceptible to the effect of ambient pollutants on stroke mortality.
Initial clinical experience of selective coronary angiography using one prolonged injection and a 180 degrees rotational trajectory.

OBJECTIVE Evaluate the safety of prolonged coronary injections during a rotational acquisition covering 180 degrees. BACKGROUND Rotational angiography has been adapted to coronary angiography and shown to reduce radiation and contrast exposure. Three-dimensional (3D) reconstructions and other advanced applications require imaging over a 180 degrees -arc with a single but longer injection of larger contrast volumes. METHODS Thirty patients referred for angiography were enrolled. Blood pressure (BP), heart rate (HR), symptoms, and ectopy were recorded before-and-after injections. RESULTS Pre and post-injection HRs for the LCA/RCA were not statistically different (LCA-pre-injection 63+/-13 bpm vs. LCA-post-injection 62+/-11 bpm, P=0.54 and RCA-pre-injection 65+/-12 bpm vs. RCA-post-injection 65+/-10, P=0.88). Central aortic pressure values were not statistically different for the RCA injections (RCA-systolic-pre-injection 118+/-14 mm Hg vs. RCA-systolic-post-injection 112+/-25 mm Hg, P=0.15, and RCA diastolic-pre-injection 69+/-9 mm Hg vs. RCA-diastolic-post-injection 60+/-10 mm Hg, P=0.88) but were statistically significant for the LCA injections (LCA systolic-pre-injection 122+/-19 mm Hg vs. LCA-systolic-post-injection 116+/-17 mm Hg, P=0.0004, and LCA-diastolic-pre-injection 69+/-10 mm Hg vs. LCA-diastolic-post-injection 65+/-9 mm Hg, P=0.0007). There were no symptoms or electrical events documented during or immediately post-injection. CONCLUSION This study demonstrates the feasibility and safety of longer coronary injections. There were no significant HR changes, clinically insignificant pressure changes, and no adverse reactions. Additional studies will be needed to assure its safety in a larger and clinically more varied patient population.
You Need to Recognize Ambiguity to Avoid it

We study the influence of attention and comprehension on ambiguity attitudes. Subjects are presented with screening questions before choosing between two alternatives represented by payoff-matrices which are essentially equivalent to those in Ellsberg’s (1961) two-urn problem. The observed rate of ambiguity aversion for the standard two-urn problem is similar to what is reported in the literature regardless of the level of comprehension. When facing the essentially equivalent yet more complex matrix-based choice task, high-comprehension subjects continue to exhibit ambiguity aversion typical of the standard two-urn problem while low-comprehension subjects appear to behave randomly. We also classify subjects as “probability minded” or “ambiguity minded” based on whether they assign probabilities to draws from a deck of cards with unknown composition during the screening phase. High-comprehension subjects who are ambiguity-minded are far more likely to be ambiguity averse than those who are probability-minded. Significantly, subject “mindedness” appears to explain ambiguity attitudes an order of magnitude more than all other demographic characteristics combined. Contrary to intuition about subjects’ sophistication, ambiguity-minded high-comprehension subjects are younger, more educated, more analytic, and more reflective about their choices compared with their probability-minded counterparts.