Miracle-dz/UniFAR-FTUs huggingface dataset:
Dietary Fibre, Fibre-depleted Foods and Disease

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Sustained release nanoparticles containing acyclovir prodrugs for ocular herpes simplex keratitis and characterization of folate transport proteins in a corneal epithelial cell line

Ocular herpes is a persistent viral infection caused by the herpes simplex virus-1. It is one of the most common infectious diseases causing corneal blindness in the United States. In this study, polymeric nanoparticles of stereoisomeric di-peptide prodrugs of acyclovir (L-valineL-valine-ACV, L-valine-D-valine-ACV, D-valine-L-valine-ACV, and D-valine-D-valine-ACV) were developed and characterized for the treatment of ocular herpes keratitis. L-valine-Lvaline-ACV and L-valine-D-valine-ACV were determined to be optimum in terms of enzymatic stability, uptake and cytotoxicity. Uptake and docking results indicated that Lvaline in the terminal position increases the affinity of prodrug to the peptide transporter protein. Entrapment efficiency values of L-valine-L-valine-ACV and L-valine-D-valine-ACV were optimal with PLGA 75:25 and PLGA 65:35 polymers, respectively. In vitro release of prodrugs from nanoparticles exhibited a biphasic release pattern with initial burst phase followed by sustained release. Dispersion of nanoparticles in thermosensitive gels eliminated the burst release phase. Novel nanoparticulate systems of dipeptide prodrugs of ACV suspended in thermosensitive gels may provide sustained delivery following topical
A Typology of Verbs Culled From 23,000 Videogame Walkthroughs

OVERVIEW In life and in videogames, verbs are really important. They constitute the essential part of speech in natural language, and in game analysis (and game design) there is the notion of game verbs, which denote core gameplay interactions (e.g., Crawford, 2003). Following Grace (2014), we assert the scholarly promise of treating verbs appearing in text describing gameplay as proxies for the actual game verbs that characterize the gameplay being described. Likewise, we invoke here our own arguments about the yet untapped potential of the sheer billions of words describing games that exist online in structured collections that are freely available (Ryan et al., 2015). From these bases, we present in this paper preliminary insights from an analysis of verb usage across 23,131 videogame walkthroughs extracted from the website GameFAQs; in total, this corpus comprises some 1.4B words. Specifically, we employ a hybrid approach (adapted from Zagal and Tomuro, 2010) that combines two modes of clustering analysis—one automated (using machine learning) and the other manual (using grounded theory)—to produce a preliminary hierarchical typology of game verbs that is based in the copious descriptive language of thousands of videogame enthusiasts. Additionally, we have built an explorable visualization of this typology, which we link to below. We hope that our typology may be of interest and use to game scholars (as an analytical starting point), and to game designers as well.
Study of Chest Physical Therapy Effect on Full Term Neonates with Primary Pneumonia: A Clinical Trial Study

Background Chest physiotherapy has been used to clear secretions in pediatrics for many respiratory problems. The aim of this study was to investigate the effect of chest physical therapy on full term neonates with primary pneumonia. Materials and Methods Sixty full term neonates admitted to neonatal intensive care unit (NICU), Minia University, Egypt, during the period from September 2016 to September, 2017 divided into two equal groups: group I included 30 patients received routine medical treatment according to American Academy of Pediatrics (AAP) recommendations and group II included another 30 patients received routine medical treatment plus chest physical therapy modalities in the form of positioning, postural drainage, percussion and vibration. We compared between the two groups as regards the duration for mechanical ventilation and/or oxygen therapy, clinical improvement, oral feeding and duration of hospitalization. Results There was significant differences between group I, neonates who received routine medical treatment) and group II, neonates who received routine medical treatment plus chest physical therapy regarding the duration needed for mechanical ventilation and/or oxygen (p<0.045), the duration needed for clinical improvement (p<0.042), the duration needed for oral feeding (p<0.035) and the duration of hospitalization (p<0.031). Conclusion According the results, chest physical therapy has a positive supportive effect on full term neonates with primary pneumonia regarding the duration needed for mechanical ventilation and/or oxygen therapy, the duration needed for clinical improvement and the duration of hospitalization.
Model-based analysis of role-based access control

Model-Driven Engineering (MDE) has been extensively studied. Many directions have been explored, sometimes with the dream of providing a fully integrated approach for designers, developers and other stakeholders to create, reason about and modify models representing software systems. Most, but not all, of the research in MDE has focused on general-purpose languages and models, such as Java and UML. Domain-specific and cross-cutting concerns, such as security, are increasingly essential parts of a software system, but are only treated as second-class citizens in the most popular modelling languages. Efforts have been made to give security, and in particular access control, a more prominent place in MDE, but most of these approaches require advanced knowledge in security, programming (often declarative), or both, making them difficult to use by less technically trained stakeholders. In this thesis, we propose an approach to modelling, analysing and automatically fixing role-based access control (RBAC) that does not require users to write code or queries themselves. To this end, we use two UML profiles and associated OCL constraints that provide the modelling and analysis features. We propose a taxonomy of OCL constraints and use it to define a partial order between categories of constraints, that we use to propose strategies to speed up the models’ evaluation time. Finally, by representing OCL constraints as constraints on a graph, we propose an automated approach for generating lists of model changes that can be applied to an incorrect model in order to fix it. All these features have been fully integrated into a UML modelling IDE, IBM Rational Software Architect.
Situação das doenças de milho no Brasil.

A cultura de milho ocupa, no Brasil, 13,6 milhões de hectares. Conquanto o milho seja cultivado em todo o país, há uma forte concentração nas regiões Sul, Sudeste e Centro-oeste, onde observou-se, pelos dados da safra 1985/86, 73% da área plantada e 88% da produção. O aumento da produção de milho nos pr6ximos anos deverá ocorrer tanto pelo aumento da área cultivada como pelo aumento da produtividade, sendo que o balanceamento entre estes dois fatores será variável de acordo com as características de cada região fisiogrãfica, Para o aumento da produtividade, prevê-se a utilização intensiva de tecnologias como uso de irrigação, utilização de plantas mais produtivas, precoces, aumento na fertilidade do solo, etc. Em uma cultura com estas características, isto é, abrangendo várias regiões que diferem entre si e dentro delas quanto ao clima e utilizando tecnologias que se relacionam diretamente com . 0 aparecimento das doenças, é de seesperar a ocorrência de um' elevado número de doenças. Assim, mais de 20 já foram identificadas na cultura de milho no Brasil. Contudo, pela freqüência e intensidade com que ocorrem, somente algumas apresentam importância econômica. Por outro lado, por ser doença o resultado da interação entre dois seres vivos (pat6geno e hospedeiro), influenciada pelas condições ambientais, basta que estas sejam favoráveis à interação ou que _ocorra variação no pat6geno para que doenças de importância secundária passem a se constituir em problemas fitopatol6gicos para a cultura do milho. Assim, é necessário àqueles que trabalham com esta cultura, não s6 conhecerem adistribuição geográfica das doenças comotambém as possíveis variações que venham a ocorrer nos pat6genos. O presente trabalho, apresentado no Simp6sio sobre Moléstias de Milho, realizado de 28 a 29 de julho de 1987, em Campinas, teve como fmalidade reunir informações sobre . as doenças mais importantes da cultura do milho, nas principais regiões produtoras. Estas informações, obtidas também através de consultas feitas a técnicos ligados a instituições oficiais de pesquisa, como IAP AR, EMPASC e companhias particulares produtoras de sementes, como Sementes Cargill Ltda. e Sementes Agroceres SI A, estão contidas nos Quadros 1,2 e 3, e nos mostram as seguintes situações para as doenças de milho nas diferentes regiões.
A Node Localization Algorithm based on Wireless Sensor Network

After analyzing the disadvantages of the centralized multidimensional localization algorithms MDS-MAP (Multi-Dimensional Scaling-MAP) in positioning accuracy and computational complexity, we present a new localization algorithm based on a set of statistical vectors (SV). The solving equation of the double center matrix can be simplified by node coordinate transformation. In order to reduce the noise disturbance and decrease the effect of ranging error on the followed location accuracy, a new coordinate inner product matrix can be reconstructed by using a set of statistical vectors, which can be used to calculate the node coordinates directly. This algorithm can realize centralized localization, distributed localization and incremental localization of nodes.
Atualização no uso de agentes antifúngicos

We summarize here data regarding the spectrum of action, the pharmacological aspects, the toxicological aspects and the clinical efficacy of liposomal amphotericin B, amphotericin B in colloidal dispersion, amphotericin B lipid complex, voriconazole and caspofungin. We discuss the use of these more recently introduced antifungal agents in terms of their safety, efficiency and cost. We also offer suggestions for the clinical use of these drugs in pulmonary and systemic infections, with an emphasis on the lower toxicity of the lipid formulations of amphotericin B in comparison with conventional medications. In addition, we explore the possibility of using voriconazole as the primary treatment for invasive infections such as aspergillosis, as well as those caused by Scedosporium spp. and Fusarium spp. , together with that of using caspofungin to treat disseminated candidiasis and invasive aspergillosis.
Equine piroplasmosis: An updated review

Summary Equine piroplasmosis (EP) is a tick-borne protozoal disease. The causative agents are Babesia caballi and Theileria equi. Horses infected with T. equi remain carriers for life. Iatrogenic means can also be factors for transmission. Typical clinical signs of acute EP can include fever, anorexia, anaemia, icterus, congested mucous membranes, tachypnoea and tachycardia, sweating, and limb and supraorbital oedema. In severe cases, haemoglobinuria and bilirubinuria are present as well as a variety of atypical presentations due to organ damage and dysfunction. Because clinical pathology is not specific of EP, accurate diagnosis requires specific diagnostic tests. The value and the pertinence of blood smears, polymerase chain reaction and serological tests are presented. Imidocarb propionate is considered as the drug of choice against EP. However, treatment strategies differ greatly between endemic and nonendemic regions. In endemic regions the goal is to reduce clinical disease because premunition plays an important role in the protection of horses, while in nonendemic regions the goal of treatment is to eliminate the risk of transmission with sterilising treatment protocols. As there is no effective vaccine available to date, prevention relies mainly on drug therapy, restriction in the movement of infected horses, and control of tick vectors.
Attracting and Retaining Faculty at New Schools of Pharmacy in the United States

These are challenging times for recruiting and retaining pharmacy faculty members at new Schools of Pharmacy. The pervasive pharmacist shortage in the United States has resulted in significantly higher salaries for pharmacists, as well as meaningful increases in student applications to pharmacy schools. So great is the demand for pharmacists that many established Schools of Pharmacy have increased their class sizes. In addition, at least nine Schools of Pharmacy have opened in the US since 1996, with at least three more scheduled to begin accepting students by the fall of 2006 (American Association of Colleges of Pharmacy, 2004). Coinciding with the pharmacist shortage is a pharmacy faculty shortage, which is exacerbated by recruitment at the newer Schools of Pharmacy and higher paying jobs in the private sector. Since, the majority of the new schools do not award Doctor of Philosophy degrees and/or have fellowship programs, they often must hire faculty members from the relatively static pool of established pharmacy programs that have Ph.D. and/or fellowship programs. This may result in a greater overall shortage of faculty. Thus, the supply side of the equation has not kept pace with the demand side, and this is especially challenging for new Schools of Pharmacy, which must recruit a full complement of faculty. A recent survey by AACP sought to determine, in part, the extent of the faculty shortage in schools of pharmacy (American Foundation of Pharmaceutical Education, 2003). Sixty-seven out of 84 pharmacy schools responded and reported an average of six open faculty positions per school, with the overwhelming majority being for full-time faculty members. Given that there is already a shortage of faculty members, a pertinent question may be, “How can new schools of pharmacy attract and retain competent faculty members? ” This is an especially critical question since most of the new pharmacy school growth is happening at small liberal arts colleges and universities that often do not possess the needed infrastructure to provide research opportunities for many new faculty members (especially basic scientists). When recruiting faculty members to new Schools of Pharmacy, department heads must articulate to potential faculty members the mission and vision of their institutions. For example, the new Schools of Pharmacy will probably require a greater teaching load than more research-intensive universities. However, this requirement may be mitigated by lower expectations for scholarship activity in the form of refereed publications and extramural funding, which provide universities with money via indirect costs to fund graduate programs. Assuming that most faculty members wish to develop professionally, the challenge for new Schools of Pharmacy is how to foster faculty satisfaction in the academic roles of teaching, scholarship and service.
Mise en débat de la figure de l'expert dans les échanges en ligne sur les changements climatiques: héros, anti-héros et représentations de la science

Cet article rend compte d’un travail exploratoire etudiant les representations de la science et des scientifiques debattues et diffusees dans des debats en ligne entre non professionnels de la science au sujet du rechauffement climatique anthropique. Nous avons analyse de maniere qualitative et comprehensive les commentaires sur deux sites ou sont discutees des theses dites « sceptiques ». Les resultats montrent que ces echanges sont le fait de communautes actives reduites developpant un propos assez structure. Les defenseurs de positions sceptiques pretendent produire un veritable discours scientifique, et developpent une representation de la science ou les sceptiques incarnent l’ideal scientifique veritable face a des institutions et des chercheurs percus comme corrompus et animes par l’ideologie. Les opposants aux vues sceptiques mettent en avant les mecanismes propres a la litterature scientifique pour refuser aux sceptiques le statut d’experts.
Development of vehicle lane changing model within U-turn facilities

U-turning movements at roadway segments are channelized and aided with splitting islands in the middle so that drivers can be on their desired trajectories and the road segment are often accompanied with weaving, merging and diverging movement. The objectives are to determine the speed differences (Vd), reaction time (RT) and safe distance where from those parameters and their relationships, the statistical model was developed and used in estimating the safe distances to execute the lane changing within the U-turn facilities. The data were taken from the field which is video recording, picture and geometric design and was used to simulate the driving simulator like an actual environment while the driving simulator come out with the speed differences, reaction time and distance as a raw data. Result show that the mean value of reaction time (RT) of the driver in making the lane changing at the U-turn area is 2.5s where the distance to execute the lane changing is 16.467m from the merging vehicle. Through the relationship between the RT, Vd and distance of the subject vehicle within U-turn facilities, the findings from the statistical model has been developed with the equation [Safe distance = (13.448 + 1.410 RT – 0.075 Vd)]. The model was used to estimate the safe distance which is 15.00m within U-turn facilities. The result shown that the safe distance will increase when the driver slowing down their speed and increasing the reaction time. The research concluded that the speed difference and reaction time have a significant relationship in estimating the safe distance in executing the lane changing within U-turn facilities.
Antimicrobial susceptibility and management of bacterial skin and soft tissue infections at Moi Teaching and Referral Hospital, Eldoret, Kenya

Background:Bacterial skin and soft tissue infections (SSTIs) are the second most common indication for antimicrobial therapy. The causative bacterial organisms are increasingly resistant, and are posing a great challenge and threat to public health, key among these being Methicillin-resistant Staphylococcus aureus (MRSA). There is little data on local antimicrobial susceptibility patterns in SSTIs and hence the approach to treatment remains a challenge. Objectives:To determine the antimicrobial susceptibility of bacterial organisms causing SSTIs and the antimicrobial management of SSTIs at the Moi Teaching and Referral Hospital (MTRH). Methods:This was a cross sectional descriptive study. Census sampling was done on patients diagnosed andadmitted with SSTIs at MTRH between January and December 2014. Pus and tissue from abscesses, cellulitis and wound infections were cultured. Bacteria were identified using gram stain and biochemical tests including indole, catalase, coagulase, oxidase, voges-proskeur, urease, bacitracin, aesculin, methyl red and citrate tests. Antimicrobial susceptibility was done using the disc diffusion method. Results:Out of 84 bacteria cultured, Staphylococcus aureus constituted 47.6%. MRSA constituted 45% of Staphylococcus aureus. Over 80% of Staphylococcus aureus were susceptible to vancomycin and ceftazidime. Likewise, other gram positive bacteria, including Enterococcus spp. , coagulase negative staphylococci and Streptococcus pyogenes were susceptible to vancomycin and clindamycin. Gramnegative bacteria were 25, and most were susceptible to meropenem and amikacin (>80%). However, Acinetobacter baumanii were not susceptible to any antimicrobial tested. Flucloxacillin and metronidazole were most used as empiric therapy, which was effective against the etiologic bacteria in 18%. Conclusions:The most common cause of SSTIs was Staphylococcus aureus, which were susceptibile to vancomycin and clindamycin. Gram-negative bacteria were susceptible to meropenem and amikacin. Most empiric therapy was not appropriate. Recommendations:Vancomycin, clindamycin, meropenem and amikacin should be used for the empiric treatment of severe SSTIs. De-escalation of this antimicrobial therapy should then be done according to the antimicrobial susceptibility results.
Teaching Faculty Perceptions of Academic Librarians at Memphis State University

In recent years academic librarians have shown increasing concern over how their teaching faculty colleagues perceive their role in the university community. Four surveys conducted on university and college campuses since the 1980s have identified attitudes held by teaching faculty. A survey conducted at Memphis State University (MSU) in the spring and fall of1990 repeated earlier survey questions and added original questions evaluating the MS U Libraries' adequacy, librarians' service, and the library collection. The Memphis State survey supplements previous findings highlighting similarities and differences in teaching faculty's perceptions and suggesting strategies to promote better understanding of academic librarians' roles. any recent studies focus on the public's perception of librarians. Academic librarians show increasing concern over how they are perceived by their faculty colleagues. Several constant factors affect the relationship between librarians and teaching faculty. They include the number of academic librarians, the strength or weakness of the collection, and the size of the institution, the faculty, the student body, and the library facility. Currently, diminishing financial resources strain this relationship even further. As early as 1%8, florence Holbrook cited Robert Leigh's observation that much of the librarian's unfavorable image can be ascribed to the fact that the nonpro-fessional library worker is more visible, and subsequently, patrons cannot determine ne who is a librarian and who is not. Faculty cannot easily distinguish between librarians and support staff. Robert Black-burn noted that teaching faculty and librarians clash because of the roles they play, competing ends, and characterdiffer-ences.2 In 1969 Maurice Marchant traced conflict between teaching faculty and librarians to anything that diminished faculty's control over students. 3 In 1981 Mary Biggs cited several sources of conflict between teaching faculty and
Relative Cognitive Complexity of the Kaufman Assessment Battery for Children (K-ABC) and the WISC-R

We evaluated whether abilities measured by the Kaufman Assessment Battery for Children (K-ABC)are as complex as those measured by the Wechsler Intelligence Scale for Children-Revised (WISC-R)within a sample of referred children. Results of factor and multidimensional scaling analyses indicated that abilities tapped by the K-ABC Mental Processing scale are not as complex as those assessed by the WISC-R. K-ABC Achievement scale subtests, however, seemed to assess skills as complex as those measured by many WISC-R subtests. The relative cognitive complexity of the K-ABC and the WISC-R seem comparable, but only when all the K-ABC subtests are administered.