Miracle-dz/UniFAR-FTUs huggingface dataset:
A Risk Score Including Carotid Plaque Inflammation and Stenosis Severity Improves Identification of Recurrent Stroke

Supplemental Digital Content is available in the text. Background and Purpose— In randomized trials of symptomatic carotid endarterectomy, only modest benefit occurred in patients with moderate stenosis and important subgroups experienced no benefit. Carotid plaque 18F-fluorodeoxyglucose uptake on positron emission tomography, reflecting inflammation, independently predicts recurrent stroke. We investigated if a risk score combining stenosis and plaque 18F-fluorodeoxyglucose would improve the identification of early recurrent stroke. Methods— We derived the score in a prospective cohort study of recent (<30 days) non-severe (modified Rankin Scale score ≤3) stroke/transient ischemic attack. We derived the SCAIL (symptomatic carotid atheroma inflammation lumen-stenosis) score (range, 0–5) including 18F-fluorodeoxyglucose standardized uptake values (SUVmax <2 g/mL, 0 points; SUVmax 2–2.99 g/mL, 1 point; SUVmax 3–3.99 g/mL, 2 points; SUVmax ≥4 g/mL, 3 points) and stenosis (<50%, 0 points; 50%–69%, 1 point; ≥70%, 2 points). We validated the score in an independent pooled cohort of 2 studies. In the pooled cohorts, we investigated the SCAIL score to discriminate recurrent stroke after the index stroke/transient ischemic attack, after positron emission tomography-imaging, and in mild or moderate stenosis. Results— In the derivation cohort (109 patients), recurrent stroke risk increased with increasing SCAIL score (P=0.002, C statistic 0.71 [95% CI, 0.56–0.86]). The adjusted (age, sex, smoking, hypertension, diabetes mellitus, antiplatelets, and statins) hazard ratio per 1-point SCAIL increase was 2.4 (95% CI, 1.2–4.5, P=0.01). Findings were confirmed in the validation cohort (87 patients, adjusted hazard ratio, 2.9 [95% CI, 1.9–5], P<0.001; C statistic 0.77 [95% CI, 0.67–0.87]). The SCAIL score independently predicted recurrent stroke after positron emission tomography-imaging (adjusted hazard ratio, 4.52 [95% CI, 1.58–12.93], P=0.005). Compared with stenosis severity (C statistic, 0.63 [95% CI, 0.46–0.80]), prediction of post-positron emission tomography stroke recurrence was improved with the SCAIL score (C statistic, 0.82 [95% CI, 0.66–0.97], P=0.04). Findings were confirmed in mild or moderate stenosis (adjusted hazard ratio, 2.74 [95% CI, 1.39–5.39], P=0.004). Conclusions— The SCAIL score improved the identification of early recurrent stroke. Randomized trials are needed to test if a combined stenosis-inflammation strategy improves selection for carotid revascularization where benefit is currently uncertain.
Characteristics of Warm Clouds and Precipitation in South China during the Pre-Flood Season Using Datasets from a Cloud Radar, a Ceilometer, and a Disdrometer

The millimeter-wave cloud radar, ceilometer, and disdrometer have been widely used to observe clouds and precipitation. However, there are some drawbacks when those three instruments are solely employed due to their own limitations, such as the fact that radars usually suffer from signal attenuation and ceilometers/disdrometers cannot provide measurements of the hydrometeors of aloft clouds and precipitation. Thus, in this paper, we developed an integrated technology by combining and utilizing the advantages of three instruments together to investigate the vertical structure and diurnal variation of warm clouds and precipitation, and the raindrop size distribution. Specifically, the technology consists of appropriate data processing, quality control, and retrieval methods. It was implemented to study the warm clouds and precipitation in South China during the pre-flood season of 2016. The results showed that the hydrometeors of warm clouds and precipitation were mainly distributed below 2.5 km and most of the rainfall events were very light with a rain rate less than 1 mm h−1, however, the stronger precipitation primarily contributed the accumulated rain amount. Furthermore, a rising trend of cloud base height from 1000 to 1900 BJT was found. The cloud top height and cloud thickness gradually increased from 1200 BJT to reach a maximum at 1600 BJT (Beijing Standard Time, UTC+8), and then decreased until 2000 BJT. Also, three periods of the apparent rainfall on the ground of the day, namely, 0400–0700 BJT, 1400–1800 BJT, and 2300–2400 BJT were observed. During three periods, the raindrops had wider size spectra, higher number concentrations, larger rain rates, and higher water contents than at other times. The hydrometeor type, size, and concentration were gradually changed in the vertical orientation. The raindrop size distributions of warm precipitation in the air and on the ground were different, which can be expressed by γ distributions N(D) = 1.49 × 104D−0.9484exp(−6.79D) in the air and N(D) = 1.875 × 103D0.862exp(−2.444D) on the ground, where D and N(D) denote the diameter and number concentration of the raindrops, respectively.
The role of paediatricians in implementing adequate social programs to assist children suffering parental loss

1European Paediatric Association-Union of National European Paediatric Societies and Associations (EPA-UNEPSA), Berlin, Germany 2Division of Gastroenterology, Department of Pediatrics, İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, İstanbul, Turkey 3Italian Society of Pediatrics (SIP), Rome, Italy 4Institute of Pediatrics, Catholic University Medical School, Rome, Italy 5Campus Bio-Medico University Medical School, Rome, Italy 6Second Pediatric Clinic, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania 7Romanian Social Pediatrics Society, Cluj-Napoca, Romania 8Italian Federation of Pediatricians, Rome, Italy 9Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy 10Department of Pediatrics, Scientific Institute “Casa Sollievo della Sofferenza”, University of Foggia, Foggia, Italy
A Software-Defined Networking approach for congestion control in Opportunistic Networking

The short-term adoption of opportunistic networks (OppNet) depends on improving the current performance of this type of network. Software-Defined Networks (SDN) architecture is used by Internet applications with high resource demand. SDN technology improves network performance by programmatically managing the network configuration by using a control layer. In this paper, we propose that OppNet nodes use a control layer to get an overview of the whole network and use this knowledge to apply policies to get a better performance of the network. As a use case for our experimentation, we have focused on improving congestion control in OppNet with a control layer that dynamically regulates the replication degree used by forwarding algorithms. We have compared the performance of our proposal with two different configurations of the OppNet, over two community scenarios based on real mobility traces. The results of the test prove that our SDN-like approach overruns the other two approaches in terms of delivery ratio and latency time performance.
The CRISPR toolbox in medical mycology: State of the art and perspectives

Fungal pathogens represent a major human threat affecting more than a billion people worldwide. Invasive infections are on the rise, which is of considerable concern because they are accompanied by an escalation of antifungal resistance. Deciphering the mechanisms underlying virulence traits and drug resistance strongly relies on genetic manipulation techniques such as generating mutant strains carrying specific mutations, or gene deletions. However, these processes have often been time-consuming and cumbersome in fungi due to a number of complications, depending on the species (e.g., diploid genomes, lack of a sexual cycle, low efficiency of transformation and/or homologous recombination, lack of cloning vectors, nonconventional codon usage, and paucity of dominant selectable markers). These issues are increasingly being addressed by applying clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9 mediated genetic manipulation to medically relevant fungi. Here, we summarize the state of the art of CRISPR–Cas9 applications in four major human fungal pathogen lineages: Candida spp. , Cryptococcus neoformans, Aspergillus fumigatus, and Mucorales. We highlight the different ways in which CRISPR has been customized to address the critical issues in different species, including different strategies to deliver the CRISPR–Cas9 elements, their transient or permanent expression, use of codon-optimized CAS9, and methods of marker recycling and scarless editing. Some approaches facilitate a more efficient use of homology-directed repair in fungi in which nonhomologous end joining is more commonly used to repair double-strand breaks (DSBs). Moreover, we highlight the most promising future perspectives, including gene drives, programmable base editors, and nonediting applications, some of which are currently available only in model fungi but may be adapted for future applications in pathogenic species. Finally, this review discusses how the further evolution of CRISPR technology will allow mycologists to tackle the multifaceted issue of fungal pathogenesis.
Factors That Protect Children From Community Violence: Applying the INSPIRE Model to a Sample of South African Children

Community violence is a prevalent form of interpersonal violence in South Africa for children living in low-income areas. Trauma arising from violence exposure is of concern in contexts where access to treatment is often unattainable. As simultaneous multisectoral strategies show higher potential to counter interpersonal violence than single interventions, the World Health Organization with partners created INSPIRE. INSPIRE takes an integrated approach coordinated across formal and informal settings of civil and private society. Responding to research paucity on methods that counter community violence in LMIC settings, this study employed a cross-sectional correlational design consisting of a sample of 2,477 children aged 10 to 17 years from the Young Carers 2009–2010 study conducted in a low-income, HIV-endemic province of South Africa highly affected by community violence. Multiple logistic regressions assessed individual and dose associations between four INSPIRE-based violence prevention strategies—positive parenting, basic necessities, formal social support, and school structural support—and direct and indirect community violence outcomes. Three strategies had significant associations with community violence outcomes: necessities (direct p < .001; adjusted odds ratio [AOR] = .57; indirect p < .01; AOR = .62), formal support (direct p < .05; AOR = .83; indirect p < .05; AOR = .73), and school support (direct p < .001; AOR = .53; indirect p < .001; AOR = .49). Combined interventions in direct and indirect community violence analyses demonstrated that children reporting a higher number of strategies were less likely to have experienced community violence. This outcome extends the results of longitudinal studies in South Africa highlighting social protection with care as a means to overcome structural deprivation strains, thereby reducing the likelihood of children’s exposure to community violence. Moreover, these findings uphold the INSPIRE model as an effective cross-sectoral approach to prevent and reduce the community violence that children experience.
Balancing the double‐edged sword effect of increased resistant starch content and its impact on rice texture: its genetics and molecular physiological mechanisms

Summary Resistant starch (RS) is the portion of starch that escapes gastrointestinal digestion and acts as a substrate for fermentation of probiotic bacteria in the gut. Aside from enhancing gut health, RS contributes to a lower glycemic index. A genome‐wide association study coupled with targeted gene association studies was conducted utilizing a diverse panel of 281 resequenced Indica rice lines comprising of ~2.2 million single nucleotide polymorphisms. Low‐to‐intermediate RS phenotypic variations were identified in the rice diversity panel, resulting in novel associations of RS to several genes associated with amylopectin biosynthesis and degradation. Selected rice lines encoding superior alleles of SSIIa with medium RS and inferior alleles with low RS groups were subjected to detailed transcriptomic, metabolomic, non‐starch dietary fibre (DF), starch structural and textural attributes. The gene regulatory networks highlighted the importance of a protein phosphatase alongside multiple genes of starch metabolism. Metabolomics analyses resulted in the identification of several metabolite hubs (carboxylic acid, sugars and polyamines) in the medium RS group. Among DF, mannose and galactose from the water‐insoluble fraction were found to be highly associated with low and medium RS lines, respectively. Starch structural analyses revealed that a moderate increase in RS is also linked to an elevation of amylose 1 and amylose 2 fractions. Although rice lines with medium RS content negatively affected textural and viscosity properties in comparison to low RS, the textural property of medium RS lines was in the same acceptable range as IR64, a rice mega variety popular in Asia.
Validity of the Medication Adherence Rating Scale for Adherence to Inhaled Corticosteroids among Older Adults with Asthma or Chronic Obstructive Pulmonary Disease

Abstract Regular use of inhaled corticosteroids (ICS) is the standard of care for patients with persistent asthma and chronic obstructive pulmonary disease (COPD). Adherence to ICS is measured using the 10-item Medication Adherence Report Scale (MARS), a self-reported medication adherence assessment. However, data on the validity of this measure are limited. Data were obtained from two cohort studies that examined the association of health literacy with self-management behaviors among adults ages 65 and older with asthma and adults ages 40 and older with COPD. ICS adherence was objectively measured over a 4-week period using electronic monitoring devices. Adequate adherence by MARS assessment was defined as a score ≥4.5, and by electronic monitoring as ≥80% of doses prescribed. We assessed the criterion validity using correlations between self-reported adherence and electronic adherence. Receiver Operating Characteristic (ROC) curve analysis was performed between the two measures. Among patients with asthma, the continuous values for adherence measured by self-report and electronically were weakly correlated (r = 0.33, p < 0.001); similarly, the agreement between the dichotomized measures was weak (kappa 0.30, p=.49). Findings were similar for COPD patients: r = 0.26, p = 0.003; kappa 0.19, p = . 60. Area under curve (AUC) values generated from ROC analysis was 0.69 and 0.61, for asthma and COPD patients, respectively. Commonly used measure for adherence performed weakly compared to electronic monitoring in separate populations of patients with asthma and COPD. Investigators measuring self-reported medication adherence among patients with these pulmonary diseases should consider using alternative instruments or using objective measures exclusively.
[Influence of dasatinib treatment on body height in children with acute myeloid leukemia].

OBJECTIVE To study the influence of dasatinib treatment on body height in children with acute myeloid leukemia (AML). METHODS A retrospective analysis was performed for the clinical data of 86 AML children aged <17 years. According to the treatment regimen, these children were divided into a conventional chemotherapy group and a dasatinib chemotherapy group. The 57 children in the conventional chemotherapy group were given conventional chemotherapy drugs without tyrosine kinase inhibitor, and the 29 children in the dasatinib chemotherapy group were given conventional chemotherapy drugs and dasatinib. The two groups were compared in terms of height standard deviation score (HtSDS) at the beginning of treatment and after treatment, as well as the change in HtSDS after 1 and 2 years of treatment. RESULTS There was no significant difference in HtSDS between the conventional and dasatinib chemotherapy groups before treatment. Within the first two years of treatment, the dasatinib chemotherapy group had a similar change trend of HtSDS as the conventional chemotherapy group. Four children in the dasatinib chemotherapy group reached the final adult height during follow-up, which was significantly lower than the target height (P=0.044). In the conventional chemotherapy group, there was no significant difference between final adult height and target height. In the dasatinib chemotherapy group, the children in adolescence had a significant change in HtSDS after treatment (P=0.032). CONCLUSIONS Dasatinib treatment may affect the final height of children with AML, and the use of dasatinib after the beginning of adolescence may lead to growth disorder, but dasatinib treatment has little effect on body height in the short-term treatment.
Sliding-Mode Surface-Based Approximate Optimal Control for Uncertain Nonlinear Systems With Asymptotically Stable Critic Structure

This article develops a novel sliding-mode surface (SMS)-based approximate optimal control scheme for a large class of nonlinear systems affected by unknown mismatched perturbations. The observer-based perturbation estimation procedure is employed to establish the online updated value function. The solution to the Hamilton–Jacobi–Bellman equation is approximated by an SMS-based critic neural network whose weights error dynamics is designed to be asymptotically stable by nested update laws. The sliding-mode control strategy is combined with the approximate optimal control design procedure to obtain a faster control action. The stability is proved based on the Lyapunov’s direct method. The simulation results show the effectiveness of the developed control scheme.
A Cuboid Model for Assessing Surface Soil Moisture

This study proposes a cuboid model for soil moisture assessment. In the model, the three edges were the meteorological, soil, and vegetation feature parameters highly related to soil moisture, and the edge lengths represented the degree of influence of each feature parameter on soil moisture. Soil moisture is assessed by the cuboid diagonal, which is referred to as the cuboid soil moisture index (CSMI) in this paper. The model was applied and validated in the Huang-Huai-Hai Plain. The results showed that (1) the difference in land surface temperature between day and night (ΔLST), land surface water index (LSWI), and accumulated precipitation (AP) were most closely correlated with soil moisture observation data in our study area, and were therefore selected as soil, crop, and meteorological system parameters to participate in CSMI calculations, respectively. (2) CSMI-1, with a cuboid length coefficient of 2/1/2, was the best model. The correlation of soil moisture derived from CSMI-1 with observed values was 0.64, 0.60, and 0.52 at depths of 10 cm, 20 cm, and 50 cm, respectively. (3) CSMI-1 had good applicability to the evaluation of soil moisture under different vegetation coverage. When the normalized difference vegetation index (NDVI)was 0–0.7, CSMI-1 was highly correlated with soil moisture at a significance level of 0.01. (4) The three-dimensional (3D) CSMI model can be easily converted to a two-dimensional (2D) model to adapt to different surface conditions (as long as the weight coefficient of one parameter is set to 0). Irrigation information (if available) can be considered as artificial recharge precipitation added in the AP to improve the accuracy of soil moisture inversion. This study provides a reference for soil moisture inversion using optical remote sensing images by integrating soil, vegetation, and meteorological feature parameters.
Strong coloring 2‐regular graphs: Cycle restrictions and partial colorings

Let H $H$ be a graph with Δ ( H ) ≤ 2 ${\rm{\Delta }}(H)\le 2$ , and let G $G$ be obtained from H $H$ by gluing in vertex‐disjoint copies of K 4 ${K}_{4}$ . We prove that if H $H$ contains at most one odd cycle of length exceeding 3, or if H $H$ contains at most three triangles, then χ ( G ) ≤ 4 $\chi (G)\le 4$ . This proves the Strong Coloring Conjecture for such graphs H $H$ . For graphs H $H$ with Δ = 2 ${\rm{\Delta }}=2$ that are not covered by our theorem, we prove an approximation result towards the conjecture.
Improvements of Motor Performances in the Drosophila LRRK2 Loss-of-Function Model of Parkinson’s Disease: Effects of Dialyzed Leucocyte Extracts from Human Serum

Within neurodegenerative syndromes, Parkinson’s disease (PD) is typically associated with its locomotor defects, sleep disturbances and related dopaminergic (DA) neuron loss. The fruit fly, Drosophila melanogaster (D. melanogaster), with leucine-rich repeat kinase 2 mutants (LRRK2) loss-of-function in the WD40 domain, provides mechanistic insights into corresponding human behaviour, possibly disclosing some physiopathologic features of PD in both genetic and sporadic forms. Moreover, several data support the boosting impact of innate and adaptive immunity pathways for driving the progression of PD. In this context, human dialyzable leukocyte extracts (DLE) have been extensively used to transfer antigen-specific information that influences the activity of various immune components, including inflammatory cytokines. Hence, the main goal of our study was to ascertain the therapeutic potential of DLE from male and female donors on D. melanogaster LRRK2 loss-of-function, as compared to D. melanogaster wild-type (WT), in terms of rescuing physiological parameters, such as motor and climbing activities, which are severely compromised in the mutant flies. Finally, in search of the anatomical structures responsible for restored functions in parkinsonian-like mutant flies, we found a topographical correlation between improvement of locomotor performances and an increased number of dopaminergic neurons in selective areas of LRRK2 mutant brains.