Miracle-dz/UniFAR-FTUs huggingface dataset:
Étude de la dynamique des interactions des constituants du complexe de biosynthèse et d’insertion de la sélénocystéine dans la traduction des sélénoprotéines in vivo

Selenoproteins are proteins that incorporate selenocysteines, which is called the 21st amino acid, during their translation. Specifically, selenocysteine (Sec) is a metabolic derivate of serine, which is structurally equivalent to Cys except for replacement of sulfur with an atom of selenium in the δ-position. It differs from other amino acids since a unique synthetase converts the serine into Sec while the residue is already attached to the tRNA. The codon for Sec on the mRNA is a UGA codon that is usually a STOP signal, introducing the concept of "recoding". Through a specific metabolic machinery for the tRNA and the presence of a SecIS (Selenocysteine Insertion Sequence) on the mRNA, this codon allows the incorporation of the Sec into the protein. However, the mechanism of biosynthesis of this amino acid and its incorporation into proteins is not well understood. It is known that the synthesis starts with the acetylation of tRNA by seryl-tRNA synthetase (SerRS) to give the seryltRNA. The latter is subsequently phosphorylated by the O-phosphoseryltRNA kinase (PSTK) which will generate the O-phosphoseryl-tRNA. Subsequently, a large complex of several proteins and cofactors acting as machinery for incorporation of Sec during translation, associates with tRNA and the mRNA and finally, the components of the ribosome. Among these proteins, SepSecS catalyzes the final step in the biosynthesis of Sec converting O-phosphoseryl-tRNA into selenocysteinyl-tRNA using monoselenophosphate as a source of selenium. Recent studies showed that the association with SECp43 would be required for SepSecS to play its role to segregate into the nucleus to be associated with the machinery that recognizes the UGA codon. Among the proteins of the biosynthesis machinery of selenoproteins that we analyzed, there are eEFSec, RPL30, SPS2, SPS1, SBP2 and NSEP1. Results of analysis of the dynamics of the interaction between the components of the Sec biosynthetic machinery confirm some data from the literature, but conflict with the model so far established. A better understanding of the dynamics of interactions between its constituents and the reaction of this process would allow us to make
Tension free, mesh free inguinal hernia repair: a prospective study of Desarda’s technique

The inguinal hernia is the most common hernia in men and women but much more common in men. Estimated lifetime for inguinal hernia is 27% for men and 3% for women. Inguinal hernia repair is one of the most common surgical procedures performed worldwide. Lichtenstein repair is the most commonly performed operation in the developed world. Lichtenstein mesh repair, however, has its own shortcomings that include recurrences (1-15%), inguinodynia, chronic groin sepsis that requires mesh removal, cost, non-availability in many parts of the developing world, and tendency to fold or wrinkle (foreign body sensation). Because of the observed complications and postoperative dysfunctions, many investigators look for new hernia repair. Efforts were made to develop a technique which is more physiological, avoids foreign body such as mesh and specifically reduces the recurrence rate and inguinodynia. An example of such an effort is the Desarda method, which was presented in 2001 and became a new surgical option for tissue-based groin hernia repair. In this technique a strip of external oblique aponeurosis was used for strengthening of the posterior wall alternative to a prosthetic mesh. It is a simple, safe, tension free, mesh free, cost effective repair. Thus we are presenting our experience in treating inguinal hernias with Desarda’s technique using continuous absorbable suture in order to ABSTRACT
Gain enhanced multipattern reconfigurable antenna for vehicular communications

This article presents the design and implementation of a high‐gain tunable dual‐band pattern reconfigurable antenna for vehicular communications. The proposed antenna consists of a slotted patch loaded with a double‐side FSS acting as superstrate. The proposed slotted antenna operates at 2.45 and 3.5 GHz and the frequency tuning over the dual‐band is accomplished by employing a varactor diode for tuning the center frequency from 2.41 to 2.62 GHz and from 3.38 to 3.65 GHz at lower and upper frequency bands, respectively. To obtain pattern reconfiguration, the slotted patch is divided into four regions by using two diagonal lines of vias. By properly choosing the excitation port combinations, 14 different radiation patterns are realized with a maximum realized gain of 8.4 and 7.9 dB. Further enhancement of gain is achieved using frequency‐selective surface (FSS) screens which act as a partially reflecting surface. The unique feature of this design is to provide reflection coefficient with high reflectivity in two predetermined frequency ranges. The prototype antenna is fabricated and the measurement results are reported. The experimental results show that the prototype antenna with FSS offers tunable dual‐band with beam reconfigurable properties.
Species and organ specificity of fungal endophytes in herbaceous grassland plants

1. aFoliar endophytic fungi in herbaceous plants are known to be diverse, yet studies characterizing the fungal communities in roots and shoots of plants across time are absent. These fungi are supposedly ubiquitous in nature, infecting plants through airborne spores. As many foliar endophytes can also exist in soil, we hypothesized that there would be a strong similarity between root and shoot endophytes in any given plant species and that differences between plant species would be greater than those between organs within a species.
The role of public health dietary messages and guidelines in tackling overweight and obesity issues

Overweight and obesity in Malaysia pose serious threats to health. Prevalence has escalated to alarming levels in recent decades despite a multitude of public health dietary messages geared towards obesity prevention and health promotion. Gaps between health messages, messengers, and the public must be identified and closed to effectively combat obesity and overweight. This review article aims to examine public health dietary messages, guidelines, and programmes for the prevention of obesity in Malaysia, and explore potential reasons for the continued rise in its prevalence. Public health dietary communication in Malaysia has progressed and improved substantially over the years. However, most messages have been designed for the general audience, with little consideration of differences in physical, social, cultural, and environmental backgrounds, and varying levels of comprehension. We offer several recommendations to increase the effectiveness of public health dietary messages in fighting the obesity epidemic, based on a cross-sectoral, place-based approach that recognise the complexity of the underlying causes of obesity.
Lactic acid bacteria: classification and physiology.

Lactic acid bacteria (LAB) constitute a group of gram-positive bacteria united by a constellation of morphological, metabolic, and physiological characteristics. The general description of the bacteria included in the group is gram-positive, nonsporing, nonrespiring cocci or rods, which produce lactic acid as the major end product during the fermentation of carbohydrates. The LAB term is intimately associated with bacteria involved in food and feed fermentation, including related bacteria normally associated with the (healthy) mucosal surfaces of humans and animals. The boundaries of the group have been subject to some controversy, but historically the genera Lactobacillus, Leuconostoc, Pediococcus, and Streptococcus form the core of the group. Taxonomic revisions of these genera and the description of new genera mean that LAB could, in their broad physiological definition, comprise around 20 genera. However, from a practical, food-technology point of view, the following genera are considered the principal LAB: Aerococcus, Carnobacterium, Enterococcus, Lactobacillus, Lactococcus, Leuconostoc, Oenococcus, Pediococcus, Streptococcus, Tetragenococcus, Vagococcus, and Weissella. The genus Bifidobacterium, often considered in the same context as the genuine lactic acid bacteria and sharing some of their typical features, is phylogenetically unrelated and has a unique mode of sugar fermentation. The classification of lactic acid bacteria into different genera is largely based on morphology, mode of glucose fermentation, growth at different temperatures, configuration of the lactic acid produced, ability to grow at high salt concentrations, and acid or alkaline tolerance. Chemotaxonomic markers such as fatty acid composition and constituents of the cell wall are also used in classification. In addition, the present taxonomy relies partly on true phylogenetic relationships,
Relative reproductive effort drives metabolic changes and maternal emaciation during pregnancy in a viviparous snake

Most viviparous squamates are lecithotrophic, and maternal effort during pregnancy mainly involves behavioural and thermoregulatory shifts to optimize developmental conditions. Still, pregnancy also imposes specific metabolic demands on the female, known as the metabolic cost of pregnancy (MCP). Contrary to the thermoregulatory shift, these energy constraints should be directly fecundity dependent and their evaluation is important to assess the ‘costs’ of viviparity. We measured the metabolic rate of aspic vipers Vipera aspis at three stages (early pregnancy, late pregnancy and post parturition), and we examined the determinants of maternal metabolic changes over time. We found a 55% metabolic increase over the course of pregnancy that was better explained by maternal relative reproductive effort (relative litter mass) when compared with absolute estimates (litter mass, litter size). After parturition, female metabolism dropped below values recorded at early pregnancy and this decrease was closely related to maternal relative reproductive effort. Our estimates for MCP ranged from 13.9 to 14.7% of maternal metabolic rate, suggesting that specific energetic demands of pregnancy are significant. It appears crucial to consider both direct (MCP) and indirect (thermoregulatory shift) components to evaluate overall maternal metabolic demand during pregnancy. Because females are already emaciated at the onset of pregnancy, these combined constraints are likely costly by inducing structural protein mobilization and altered performances after parturition.
Identification of cis and trans factors that regulategenetic stability in Saccharomyces cerevisiae

The genome of an organism is not uniformly mutagenic. The overall aim of this project was to identify cis and trans factors that may contribute to such differential mutagenic activities within the genome using Saccharomyces cerevisiae. A well-characterised recombination reporter construct, hisG-URA3-hisG, was separately introduced into five different locations of chromosome III. Each locus had differing features with respect to their replication dynamics: three replication termination sites, two of which coincided with “Replication Slow Zones” (RSZ; Cha and Kleckner, 2002), one replication origin and a region of no discernable feature. Fluctuation analysis was used to assess the rate of URA3 inactivation at each locus. First, the effects of temperature, a replication inhibitor hydroxyurea, and ploidy were assessed. Significant differences in mutation rates existed in diploid strains heterozygous for the construct in these conditions, but not in respective haploids. The effects of inactivating various genes known to be involved in genome stability were also examined. Elimination of an essential signal transduction protein, Mec1p, or a DNA helicase required for efficient replication, Rrm3p, led to an increase in mutation rates only in diploid strains. No statistically significant effect was seen when a top2 temperature-sensitive allele was used in either haploids or diploids. In general, no cis effect was observed in any of these mutant backgrounds. The nature of genetic alterations associated with URA3 inactivation was also determined by Southern analysis for the five loci. The analysis revealed that the nature of genetic alteration is regulated in a cis manner, as URA3 inactivation was either exclusively via recombination or by small changes depending on the location of the reporter construct. These findings reveal some unexpected ways in which cis and trans factors may regulate mutagenic events in budding yeast. These will be discussed in context of eukaryotic genome instability in general.
Dual 3D Ceramic Textile Electrodes: Fast Kinetics for Carbon Oxidation Reaction and Oxygen Reduction Reaction in Direct Carbon Fuel Cells at Reduced Temperatures

Direct carbon fuel cells (DCFCs) are an efficient energy‐conversion technology capable of generating electricity with carbon‐dioxide‐capture chemistry with solid carbon as fuels. The efficiency and performance of DCFCs depend on the kinetics of the carbon oxidation reactions (COR) and the oxygen reduction reactions (ORR), each occurring at anode and cathode, respectively. The limited active sites paired with reduced temperatures greatly decrease the efficiency of the electrochemical reactions. Ultraporous dual‐3D ceramic textiles (dual‐3DCT) are integrated into electrolyte‐supported DCFCs to enhance charge and mass transfer at the electrodes. Improved COR at the anode is achieved by the synergy between the 3DCT NiO–Ce0.8Gd0. 2O1.95 (GDC) structure and optimal carbon fuel choice. In a comparative study, DCFCs using graphitic carbon (GC) as fuel show the best COR performance when compared to DCFCs utilizing alternative fuels such as carbon black (CB) and activated carbon (AC). The 3DCT Sm0.5Sr0. 5CoO3‐δ–GDC (SSC–GDC) composite cathode shows electrochemical performance superior to that of the conventional screen‐printed SSC–GDC. A peak power density of 392 mW cm−2 at 600 °C is obtained in a DCFC using the 3DCT‐anode/electrolyte/3DCT‐cathode configuration, an unprecedented value for any reported DCFC as of yet. This points toward promising applications of dual‐3DCT electrodes for reduced‐temperature DCFCs.
Research on User Clustering Algorithm Based on Improved ROCK Algorithm

This paper analyzes the merits and demerits of the ROCK algorithm firstly, then indicates that the merits of Rock is easy to cluster categorical database such as Mushroom, and the demerits is that the similarity formula sim of this algorithm depends on the intuition of domain experts. The improved ROCK gets the result of clustering by calculating the similarity using Jaccard coefficient based on the reason which is that the bigger figure of the similarity is, the more alike the object is. Then we can implement personality recommendation according to the result.
A eficiência de mercado futuro do café no Brasil: uma abordagem por meio da regressão quantílica

The present paper intends to verify the brazilian future market’s efficiency for the arabica coffee, according to the contracts negotiated in B3 between 2007 and 2017. For this, the method of ordinary least squares and quantile regression was applied. The results indicated that the series are stationary of first order and the test of Engle and Granger indicated that the models are cointegrated. The residue tests made it impossible to interpret the OLS, indicating that its use is not adequate. However, the same does not occur with the quantile regression, which presented in the long term an increase of the optimal rate and the market efficiency, with risk premium where the price oscillations were higher and in the short term the opposite occurs.
The Oestrid Flies: Biology, Host-Parasite Relationships, Impact and Management

Introduction, D D Colwell, M J R Hall and P J Scholl Historical Perspectives on the Importance and Impact of Oestrids, R A Roncalli, Milltown, USA Phylogeny and Evolution of the Bot Flies, T Pape, Zoological Museum, Copenhagen, Denmark Molecular Phylogeny and Identification, D Otranto, University of Bari, Italy and J R Stevens, University of Exeter, UK Life Cycle Strategles, D D Colwell Morphology of Adult Oestridae, D M Wood, Agriculture and Agri-Food Canada Egg Morphology, D D Colwell Larval Morphology, D D Colwell Pupal Biology and Metamorphosis Behaviour, A C Nilssen, Tromso Museum, Norway Adult Biology, J R Anderson, Bend, USA Larval - Host Parasite Relationships, C Boulard, INRA, France, E Lello, Botucatu, Brazil, D Colwell and P Dorchies, Ecole Nationale Veterinaire de Toulouse, France Oestrid Myiasis of Humans, J R Anderson Management and Control of Oestrid Flies, P J Scholl A Synopsis of the Biology, Hosts, Distribution, Disease, D D Colwell, M J R Hall and P J Scholl.
An infrequent association: Left ventricular non compaction with bicuspid aortic valve and coarctation of the aorta.

Left ventricular non compaction (LVNC) is a condition rarely diagnosed and reported in current literature. It affects approximately 8 to 12 per 1 million of individuals and its causes are not well understood, but they are linked to gene mutations. The authors present a 29-year-old male who came to medical consult for a pre surgical evaluation. He was completely asymptomatic. Due to an aortic diastolic murmur we performed a transthoracic echocardiogram which revealed severe aortic regurgitation, signs of left ventricular non compaction and coarctation of the aorta. Subsequently, we decided to send him for a CT scan and CMR that allowed to confirm our diagnosis and gave more support to our findings. We ́re aimed to report this case because LVNC was found in a patient without symptoms but with a murmur missed in previous medical evaluations. Then, we encourage to be very accurate in patient’s examination and use noninvasive methods properly in order to identify such important cases.
Reactivity of 12, 13-Epoxytrichothecenes with Epoxide Hydrolase, Glutathione-S-Transferase and Glutathione

Interaction of the 12, 13-epoxytrichothecenes and related mycotoxins with epoxide hydrolase and glutathione-S-transferase (GSH-S-transferase) from rat liver was examined in vitro. Neither hydrolysis of safrole oxide by the microsomal epoxide hydrolase nor conjugation of 2, 3-epoxy-(p-nitrophenoxy) propane with GSH by the soluble GSH-S-transferase was interfered with the trichothecenes such as T-2 toxin and fusarenon-X. Gas-liquid chromatography (GLC) analysis and colorimetric determination of the residual GSH revealed that the trichothecenes were inert to the partially purified GSH-S-transferase. In contrast to the trichothecenes, PR-toxin, an epoxide mycotoxin from Penicillium roqueforti, and lactones such as patulin and penicillic acid from Penicillium and Aspergillus spp. , were found to react non-enzymatically with GSH in molar ratio of 1 : 1.
Colletotrichum destructivumによるシソ炭疽病(新称)(学術報告)

KAWARADANI ， M.h ， NISHIMURA ， A 人 MORIWAKI ，]人 TOMIOKA ， K 人 SATO ， T. 4 ， OKADA ， K. 1 and NAKASONE ， W 1 (2008). An thracnose of perilla (Perilla ocymoides 1.) caused by Colletotrichum destructivum. ]pn. ]. Phytopatho l. 74: 335-339. Brown leaf spots and shoot blight were observed on perilla (Perilla ocymoides 1.) in Osaka Prefecture in] une 2006. The causal agent was identified as Colletotrichum destructivum O'Gara. The same symptoms were produced after inoculating perilla plants with present isolate. This report is the first of anthracnose of perilla in ]apan. This pathogen ， originally found on a reddish purple cultivar of perilla (akajiso) ， also infects P. frutescens (L ふ (Received 2008)
Diş Hekimliğinde Kazein Fosfopeptit Amorf Kalsiyum Fosfat: Bir Literatür Derlemesi

Casein is a phosphoprotein in bovine milk and accounts for almost 80 percent of its total protein. Casein fosfopeptit (CPP) is produced as a result of decomposition of casein with trypsin enzyme using a selective deposition method. CPP can remarkably stabilize calcium phosphate in a state-forming CPPamorphous calcium phosphate (ACP) complex. CPPACP is located in topical gels, sugar-free chewing gum and mint dragees at the present day. In this paper, the effectiveness of CPP-ACP and usage in dentistry are presented with a wide review of the literature.
Insights into the influence of the capsule on powder de-agglomeration and drug-carrier detachment in a capsule-based dry powder inhaler

This thesis describes a body of work specifically focusing on the influence of the capsule on powder emitted dose, fluidisation, de-agglomeration and drug-carrier detachment in the context of capsule-based dry powder inhalers namely the Rotahaler ® device. By modifying the movement of the capsule during device actuation, further insight into the dominant influence of capsule-based dry powder performance were attained.
Second-Order Approximation of the Seismic Reflection Coefficient in Thin Interbeds

As most of the lithostratigraphic reservoirs in China are thin interbeds, the study of seismic responses in thin interbeds is an integral part of lithologic reservoir exploration. However, at present, the research on seismic reflection coefficients of thin interbeds in exploration seismology is still weak, which leads to the lack of theoretical basis for the subsequent interpretation of amplitude variation with offset (AVO) related to thin interbed. To solve this problem, in this paper, we proposed second-order approximate equations of the seismic reflection coefficients in thin-bed and thin-interbed layers. Under the assumption of a small impedance contrast in layered media, we made a second-order approximation with a more evident physical meaning to the reflection coefficient calculation method proposed by Kennett. Then, based on the test of the single thin-layer theoretical model, it was confirmed that the second-order approximation equation of the PP-wave (reflected compressional wave) is accurate at incident angles less than 30°, and that of the PS-wave (converted shear wave) is accurate at wider incident angles. Finally, based on the single-thin-bed equations, the approximate equations of seismic reflection coefficients in thin interbeds were established, the validity of which was verified by the theoretical model. Our equations will be applicable to the calculation of PP- and PS-wave reflection coefficients in thin interbeds where internal multiples are difficult to suppress and transmission loss is hard to accurately compensate. This lays a theoretical foundation for improving the seismic prediction accuracy of lithologic reservoirs.
The 3D Seismic Azimuthal Anisotropies and Velocities in the Eastern Tibetan Plateau Extracted by an Azimuth‐Dependent Dispersion Curve Inversion Method

An azimuth‐dependent dispersion curve inversion (ADDCI) method is applied to Rayleigh waves to extract 3D velocity and azimuthal anisotropy. The synthetic tests show that the ADDCI method is able to extract azimuthal anisotropy at different depths. The errors of the fast propagation direction (FPD) and the magnitude of the anisotropy (MOA) are less than 10° and 1–2%, respectively. The 3D anisotropic model shows large variations in the FPDs and MOAs with depth and blocks; strong contrasts are observed across major faults, and the average MOA in the crust is approximately 3%. The FPDs are positively correlated with the GPS velocity direction and the strikes of regional faults in most of the blocks. The low‐velocity zones (LVZs) in middle to lower crust are widely observed in the Songpan‐Ganze terrane, the north Chuan‐Dian block, and surprisingly in the Huayingshan thrust and fold belt. The LVZs in middle crust are also positively correlated with a region of low velocities in the uppermost mantle. These observations may suggest that large‐scale deformation is coupled vertically from surface to uppermost mantle. Crust shortening by the pure shearing process, which involves the thrusting and folding of the upper crust and the lateral extrusion of blocks, may be the major mechanism causing the growth of the eastern Tibetan Plateau.