Miracle-dz/UniFAR-FTUs huggingface dataset:
Global collapse of molecular clouds as a formation mechanism for the most massive stars

The relative importance of primordial molecular cloud fragmentation versus large-scale accretion still remains to be assessed in the context of massive core/star formation. Studying the kinematics of the dense gas surrounding massive-star progenitors can tell us the extent to which large-scale flow of material impacts the growth in mass of star-forming cores. Here we present a comprehensive dataset of the 5500(±800) M⊙ infrared dark cloud SDC335.579-0.272 (hereafter SDC335), which exhibits a network of cold, dense, parsec-long filaments. Atacama Large Millimeter Array (ALMA) Cycle 0 observations reveal two massive star-forming cores, MM1 and MM2, sitting at the centre of SDC335 where the filaments intersect. With a gas mass of 545(-385+770) M⊙ contained within a source diameter of 0.05 pc, MM1 is one of the most massive, compact protostellar cores ever observed in the Galaxy. As a whole, SDC335 could potentially form an OB cluster similar to the Trapezium cluster in Orion. ALMA and Mopra single-dish observations of the SDC335 dense gas furthermore reveal that the kinematics of this hub-filament system are consistent with a global collapse of the cloud. These molecular-line data point towards an infall velocity Vinf = 0.7( ± 0.2) km s-1, and a total mass infall rate Ṁinf ≃ 2.5(±1.0) × 10-3 M⊙ yr-1 towards the central pc-size region of SDC335. This infall rate brings 750(±300) M⊙ of gas to the centre of the cloud per free-fall time (tff = 3 × 105 yr). This is enough to double the mass already present in the central pc-size region in 3.5-1.0+2.2 × tff. These values suggest that the global collapse of SDC335 over the past million year resulted in the formation of an early O-type star progenitor at the centre of the cloud’s gravitational potential well.
Singing the Praise of Empowerment: Or Paying the Cost of Chaos

Empowerment is based on the belief that employees have the ability, and the desire, to shoulder more responsibility and perform better when given freedom. In an empowered organization, authority is given to employees with the intent to increase responsiveness to customers, improve decision-making power and to increase team motivation and skills. However, while most studies picture empowerment as the "ideal state" and the place where all organizations strive to be, our research shows that fully empowered teams without strategic guidance suffer from a number of problems. Based on multi-case study research in eleven software-intensive companies, we see that companies need to allow for different levels of empowerment depending on what they aim to achieve, characteristics of the industry domain, the business model and other factors, and that strategic guidance is critical to set direction and for avoiding chaos. To help companies approach the optimal level of empowerment, we provide a framework consisting of two inter-connected models that help companies to, rather than staying in their current hierarchical structures, transition to a level of empowerment that maximizes business value and performance.
WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4

WAVE2 is a member of the WASP/WAVE family of actin cytoskeletal regulatory proteins; unfortunately, little is known about its function in pancreatic cancers. In this study, we report the role of WAVE2 in the motility and invasiveness of pancreatic cancer cells. High WAVE2 expression in human pancreatic cancer tissues was correlated with overall survival. WAVE2 accumulated in the cell protrusions of pancreatic cancer cell lines. Downregulation of WAVE2 by small interfering RNA decreased the cell protrusions and inhibited the motility and invasiveness of pancreatic cancer cells. WAVE2 promoted pancreatic cancer cell motility and invasion by forming a complex with the actin cytoskeletal protein alpha‐actinin 4 (ACTN4). Downregulation of ACTN4 by small interfering RNA also inhibited the motility and invasiveness of the cells through a decrease in cell protrusions. Further investigation showed that WAVE2/ACTN4 signaling selectively stimulated p27 phosphorylation and thereby increased the motility and invasiveness of the cells. These results suggest that WAVE2 and ACTN4 stimulate p27 phosphorylation and provide evidence that WAVE2 promotes the motility and invasiveness of pancreatic cancer cells.
Activation of Nrf2 by Sulforaphane Inhibits High Glucose-Induced Progression of Pancreatic Cancer via AMPK Dependent Signaling

Background/Aims: Sulforaphane (SFN) is known for its potent bioactive properties, such as anti-inflammatory and anti-tumor effects. However, its anti-tumor effect on pancreatic cancer is still poorly understood. In the present study, we explored the therapeutic potential of SFN for pancreatic cancer and disclosed the underlying mechanism. Methods: Panc-1 and MiaPaca-2 cell lines were used in vitro. The biological function of SFN in pancreatic cancer was measured using EdU staining, colony formation, apoptosis, migration and invasion assays. Reactive oxygen species (ROS) production was measured using 2’-7’-Dichlorofluorescein diacetate (DCF-DA) fluorometric analysis. Western blotting and immunofluorescence were used to measure the protein levels of p-AMPK and epithelial-mesenchymal transition (EMT) pathway-related proteins, and cellular translocation of nuclear factor erythroid 2-related factor 2 (Nrf2). Nude mice and transgenic pancreatic cancer mouse model were used to measure the therapeutic potential of SFN on pancreatic cancer. Results: SFN can inhibit pancreatic cancer cell growth， promote apoptosis, curb colony formation and temper the migratory and invasion ability of pancreatic cancer cells. Mechanistically, excessive ROS production induced by SFN activated AMPK signaling and promoted the translocation of Nrf2, resulting in cell viability inhibition of pancreatic cancer. Pretreatment with compound C, a small molecular inhibitor of AMPK signaling, reversed the subcellular translocation of Nrf2 and rescued cell invasion ability. With nude mice and pancreatic cancer transgenic mouse, we identified SFN could inhibit tumor progression, with smaller tumor size and slower tumor progression in SFN treatment group. Conclusion: Our study not only elucidates the mechanism of SFN-induced inhibition of pancreatic cancer in both normal and high glucose condition, but also testifies the dual-role of ROS in pancreatic cancer progression. Collectively, our research suggests that SFN may serve as a potential therapeutic choice for pancreatic cancer.
Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS‐III—Omics

Biological and technical variability has been increasingly appreciated as a key factor impacting red blood cell (RBC) storability and, potentially, transfusion outcomes. Here, we performed metabolomics analyses to investigate the impact of factors other than storage duration on the metabolic phenotypes of stored RBC in a multicenter study.
Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women

Objective: Oxidized low-density lipoprotein (LDL) seems to play an important role in the etiology of atherosclerosis. To further study this, we performed two studies: (1) we determined the ability of 10 estrogen components of the drug, conjugated equine estrogen (CEE), trans-resveratrol (t-resveratrol) and quercetin (red wine components), trolox (vitamin E analog), and probucol (a serum cholesterol-lowering drug) to delay or prevent the oxidation of plasma LDL isolated from untreated postmenopausal women, and (2) we assessed the effect of long-term (>1 year) estrogen replacement therapy and hormone replacement therapy on LDL oxidation by ex vivo methods. Design: For the in vivo study, three groups of postmenopausal women were selected based on whether they were on long-term CEE therapy (group A: 0.625 mg CEE; n = 21), on combination CEE plus progestogen therapy (group B: 0.625 mg CEE + 5.0 mg medroxyprogesterone acetate, 10 days; n = 20), or not on any hormone therapy (group C; n = 37). For the in vitro study, only LDL samples obtained from group C were used. The kinetics of LDL oxidation were measured by continuously monitoring the formation of conjugated dienes followed by determination of the lag time. Results: All compounds tested protected the LDL from oxidative damage. The relative antioxidant potency of estrogen components was generally greater than that of the other compounds. The minimum dose (nmoles) required to double the lag time from the control lag time of 57 ± 2 min was 0.47 for 17&bgr;-dihydroequilenin, 17&agr;-dihydroequilenin, &Dgr;8-estrone; 0.6 to 0.7 for &Dgr;8-17&bgr;-estradiol, equilenin, and quercetin; 0.9 for 17&bgr;-dihydroequilin and 17&agr;-dihydroequilin; 1.3 for equilin, estrone, 17&bgr;-estradiol, 17&agr;-estradiol; 1.4 for trolox; 1.9 for probucol; and 3.0 for t-resveratrol. The data from the in vivo study indicate that after long-term estrogen replacement therapy (group A) and hormone replacement therapy (group B), the LDL was significantly (p < 0.01) protected (higher lag time) against oxidation compared with the control (group C). There was no difference between groups A and B. Conclusions: The oxidation of LDL isolated from postmenopausal women is inhibited differentially by various estrogens and other antioxidants. The unique ring B unsaturated estrogen components of CEE were the most potent, and t-resveratrol, the red wine component, was the least potent. Long-term CEE or CEE + medroxyprogesterone acetate administration to postmenopausal women protects the LDL against oxidation to the same extent. These combined data support the hypothesis that some of the cardioprotective benefits associated with CEE therapy and perhaps red wine consumption may be due to the ability of their components to protect LDL against oxidative modifications.
Patient safety problems from healthcare information technology in medical imaging

Health information technology (HIT) systems have been deployed extensively by healthcare organizations and promoted as a panacea to many of the challenges faced by medical imaging departments, particularly with respect to workflow, efficiency and diagnostic accuracy. This report describes how inadequate planning, integration, training and testing of HIT can impact on patient safety and result in patient harm.
Modeling the Hysteresis Loop of Ultra-High Permeability Amorphous Alloy for Space Applications

This paper presents investigation results regarding the Jiles-Atherton-based hysteresis loop modeling of ultra-high permeability amorphous alloy MELTA® MM-5Co. The measurement stand is capable of accurately measuring minor and major hysteresis loops for such a material together with exemplary measurement results. The main source of the measurement error is highlighted, which includes the Earth’s field influence. The results of hysteresis loop modeling with the original Jiles-Atherton model and with two of its modifications are given. In all cases, the parameters of the Jiles-Atherton model were identified in two-step identification on the basis of a differential evolution optimization algorithm. The results indicate that both the original and modified Jiles-Atherton models are suitable for modeling the ultra-soft amorphous alloy. However, the hysteresis model’s parameters vary significantly.
Research on the dynamic effect of the intelligent urban experience to the tourists' two‐way internet word‐of‐mouth

As the scene experience tourism enterprises develop rapidly in the market, more and more users begin to experience this type of tourism products in the tourism of affair at the beginning, but with the increase of the wisdom of the city experience popularity and user stickiness, more tourism enterprises get the opportunities. Early feedback of the wisdom of the city has become the effective way to get the reputation from other users through the user experience and earn a reputation at the same time; tourism enterprises have also been hurt by negative word‐of‐mouth users, and various contradictions become more and more apparent. Based on the previous literature, this paper studied the relationship between enterprises and tourism enterprises from Gu networking in the process of investigation, and the relationship among negative word‐of‐mouth users. In‐depth research and analysis were also done among the users through the dynamic relationship between evolutionary game theory and tourism scene experience. Quantitative research on evolution model in tourism enterprises and in the case of the external competition will investigate the negative reputation of the user, analyze negative word‐of‐mouth users and maintain positive word‐of‐mouth users, and give the corresponding countermeasures that the tourism enterprises should take, as things really play to verify efficacy and enterprise efficient user management to provide the reference. At the same time, whether the control of the measures is analyzed by the evolution of phase diagram, it defines the essence of tourism enterprises and the relationship among negative word‐of‐mouth competing users.
Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment

The prevalence of autoimmune diseases has been increasing over the last 20 years. The clinical presentation of this large and heterogeneous group of disorders depends on whether the involvement is organ-specific or non-organ-specific. Dizziness, vertigo, and disequilibrium are common symptoms reported by patients with vestibulocochlear involvement. The association of vertigo and autoimmune diseases has been largely documented, suggesting that autoimmune disorders could be overrepresented in patients with vertigo in comparison to the general population. The aim of this review is to present the recent literature findings in the field of autoimmune-mediated diseases with cochleovestibular involvement, focusing on the clinical presentation, diagnosis, and treatment of immune-mediated inner ear diseases including autoimmune inner ear disease (AIED), Meniere's disease, and bilateral vestibulopathy, as well as of systemic autoimmune diseases with audiovestibular disorders, namely, Behçet's disease, Cogan's syndrome, sarcoidosis, autoimmune thyroid disease, Vogt-Koyanagi-Harada syndrome, relapsing polychondritis, systemic lupus erythematosus, antiphospholipid syndrome, IgG4-related disease, and ANCA-associated vasculitides.
Resource Management in Energy Harvesting Cooperative IoT Network under QoS Constraints

Cooperative communication with RF energy harvesting relays has emerged as a promising technique to improve the reliability, coverage, longevity and capacity of future IoT networks. An efficient relay assignment with proper power allocation and splitting is required to satisfy the network’s QoS requirements. This work considers the resource management problem in decode and forward relay based cooperative IoT network. A realistic mathematical model is proposed for joint user admission, relay assignment, power allocation and splitting ratio selection problem. The optimization problem is a mixed integer non-linear problem (MINLP) whose objective is to maximize the overall sum rate (bps) while satisfying the practical network constraints. Further, an outer approximation algorithm is adopted which provides epsilon-optimal solution to the problem with guaranteed convergence and reasonable complexity. Simulations of the proposed solution are carried out for various network scenarios. The simulation results demonstrate that cooperative communication with diversity achieves a better admission of IoT users and increases not only their individual data rates but also the overall sum rate of an IoT network.
Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma

Purpose: To investigate genomic differences between urothelial carcinomas of the upper tract (UTUC) and bladder (UCB), with a focus on defining the clonal relatedness of temporally distinct tumors. Experimental Design: We prospectively sequenced tumors and matched germline DNA using targeted next-generation sequencing methods. The cohort included 195 UTUC patients and 454 UCB patients. For a subgroup of 29 patients with UTUC and a history of a subsequent UCB, both tumors were analyzed to assess their clonal relatedness. Results: With the progression to higher UTUC clinical state, there were fewer alterations in the RTK/RAS pathway but more alterations in TP53/MDM2. Compared with UCB, TP53, RB1, and ERBB2 were less frequently altered in UTUC (26% vs. 46%, 3% vs. 20%, 8% vs. 19%, respectively; Q < 0.001), whereas FGFR3 and HRAS were more frequently altered (40% vs. 26%, 12% vs. 4%, respectively; Q < 0.001). On the basis of an integrated analysis of tumor mutational burden, MSIsensor score and mutational signature, 7.2% of UTUC tumors were classified as MSI-high/MMR-deficient (MSI-H/dMMR). The risk of bladder recurrence after UTUC was significantly associated with mutations in FGFR3, KDM6A, CCND1, and TP53. Comparison of UCB with corresponding UTUC tumors from the same patient supports their clonal relatedness. Conclusions: UTUC and UCB exhibit significant differences in the prevalence of common genomic alterations. In individual patients with a history of both tumors, UCB and UTUC were always clonally related. Genomic characterization of UTUC provides information regarding the risk of bladder recurrence and can identify tumors associated with Lynch syndrome.
Milk microbiome diversity and bacterial group prevalence in a comparison between healthy Holstein Friesian and Rendena cows

Dry and early lactation periods represent the most critical phases for udder health in cattle, especially in highly productive breeds, such as the Holstein Friesian (HF). On the other hand, some autochthonous cattle breeds, such as the Rendena (REN), have a lower prevalence of mastitis and other transition-related diseases. In this study, milk microbiota of 6 HF and 3 REN cows, all raised on the same farm under the same conditions, was compared. A special focus was placed on the transition period to define bacterial groups’ prevalence with a plausible effect on mammary gland health. Four time points (dry-off, 1 d, 7–10 d and 30 d after calving) were considered. Through 16S rRNA sequencing, we characterized the microbiota composition for 117 out of the 144 milk samples initially collected, keeping only the healthy quarters, in order to focus on physiological microbiome changes and avoid shifts due to suspected diseases. Microbial populations were very different in the two breeds along all the time points, with REN milk showing a significantly lower microbial biodiversity. The taxonomic profiles of both cosmopolitan and local breeds were dominated by Firmicutes, mostly represented by the Streptococcus genus, although in very different proportions (HF 27.5%, REN 68.6%). Large differences in HF and REN cows were, also, evident from the metabolic predictive analysis from microbiome data. Finally, only HF milk displayed significant changes in the microbial composition along the transition period, while REN maintained a more stable microbiota. In conclusion, in addition to the influence on the final characteristics of dairy products obtained from milk of the two breeds, differences in the milk microbiome might, also, have an impact on their mammary gland health.
One-point fluctuation analysis of the high-energy neutrino sky

We perform the first one-point fluctuation analysis of the high-energy neutrino sky. This method reveals itself to be especially suited to contemporary neutrino data, as it allows to study the properties of the astrophysical components of the high-energy flux detected by the IceCube telescope, even with low statistics and in the absence of point source detection. Besides the veto-passing atmospheric foregrounds, we adopt a simple model of the high-energy neutrino background by assuming two main extra-galactic components: star-forming galaxies and blazars. By leveraging multi-wavelength data from Herschel and Fermi, we predict the spectral and anisotropic probability distributions for their expected neutrino counts in IceCube. We find that star-forming galaxies are likely to remain a diffuse background due to the poor angular resolution of IceCube, and we determine an upper limit on the number of shower events that can reasonably be associated to blazars. We also find that upper limits on the contribution of blazars to the measured flux are unfavourably affected by the skewness of the blazar flux distribution. One-point event clustering and likelihood analyses of the IceCube HESE data suggest that this method has the potential to dramatically improve over more conventional model-based analyses, especially for the next generation of neutrino telescopes.
Multi-Level Memory for Task Oriented Dialogs

Recent end-to-end task oriented dialog systems use memory architectures to incorporate external knowledge in their dialogs. Current work makes simplifying assumptions about the structure of the knowledge base, such as the use of triples to represent knowledge, and combines dialog utterances (context) as well as knowledge base (KB) results as part of the same memory. This causes an explosion in the memory size, and makes the reasoning over memory harder. In addition, such a memory design forces hierarchical properties of the data to be fit into a triple structure of memory. This requires the memory reader to infer relationships across otherwise connected attributes. In this paper we relax the strong assumptions made by existing architectures and separate memories used for modeling dialog context and KB results. Instead of using triples to store KB results, we introduce a novel multi-level memory architecture consisting of cells for each query and their corresponding results. The multi-level memory first addresses queries, followed by results and finally each key-value pair within a result. We conduct detailed experiments on three publicly available task oriented dialog data sets and we find that our method conclusively outperforms current state-of-the-art models. We report a 15-25% increase in both entity F1 and BLEU scores.
Novel staining procedures for whole mount preparations of greater wax moth (Galleria mellonella) embryos: toluidine blue-rhodamine B, plus calcofluor white

ABSTRACT Although hematoxylin and eosin (H & E) staining of sectioned embryonic insect material is widely used, it is time-consuming and may not provide sufficient information. We evaluated new staining procedures for embryonic whole mounts of the greater wax moth, Galleria mellonella. We compared a combination of toluidine blue and rhodamine B (TB-RB) to H & E; we also investigated calcofluor white (CFW) staining. TB-RB staining produced staining similar to H & E. TB-RB staining was less time-consuming and improved visualization of the blastoderm and its differentiation into the germ disk and serosa membrane. CFW enhanced details of mitosis in nuclei post-fertilization and stained the primary serosal membrane. Staining of whole mounts with TB-RB and CFW enabled embryonic staging that was more rapid, convenient and effective than the routine approach using H & E and fluorescent probes.