Miracle-dz/UniFAR-FTUs huggingface dataset:
Introduction to Special Issue on Body Tracking and Healthcare

This Special Issue on Body Tracking and Healthcare highlights the exciting possibilities that sensor technologies are opening up in health and well-being. From the assessment and monitoring of medical conditions, to new opportunities for rehabilitation, to innovations in interaction in the operating theatre, body-tracking technology makes possible a whole new world of applications and systems. One important aspect of this change is that advances in the availability, diversity, cost, robustness, weight, accuracy, and reliability of these sensing systems have meant that we are now seeing a move out of controlled, specialist laboratory settings into the real world. Whether it be the clinic, the operating theatre, the home, or out and about in the world at large, developing healthcare applications for everyday life presents a new set of challenges for researchers, designers, and developers of these systems. When it comes to body-tracking technologies, this shift out of the laboratory is having a profound impact. For the clinical world, it has opened up new opportunities to capture, assess, monitor, and diagnose a much more diverse range of medical conditions both in and outside of the clinic. More than this, it offers up ways of more actively engaging patients in their own treatment and rehabilitation. Systems can be more interactive and can be used now not simply under the watchful eye of the health professional but also at home or with a carer. Given the potential benefits in these kinds of uses, there are many circumstances where these can be traded off against potential performance costs (in terms of accuracy and precision) arising when moving
Zonal heterogeneity of the effects of chronic ethanol feeding on hepatic fatty acid metabolism

Periportal and perivenous hepatocytes were isolated from rats fed a high‐fat, ethanol‐containing diet to investigate the acinar heterogeneity of the effects of prolonged ethanol administration on lipid metabolism. Chronic feeding of ethanol caused a rather selective accumulation of triacylglycerols in the perivenous zone of the liver. In control animals the rate of lipogenesis and the activity of acetyl‐CoA carboxylase were higher in perivenous than in periportal hepatocytes, whereas the rate of fatty acid oxidation and the activity of carnitine palmitoyltransferase I were higher in periportal than in perivenous cells; however, no zonation was evident for very‐low‐density‐lipoprotein‐lipid secretion. Prolonged ethanol administration abolished the zonal asymmetry of the lipogenic process and inverted the acinar distribution of the fatty acid—oxidative process (i.e., in ethanol‐fed animals the rate of fatty acid oxidation and the activity of carnitine palmitoyltransferase I were higher in perivenous than in periportal hepatocytes). Moreover, chronic feeding of ethanol led to a marked and selective inhibition of very‐low‐density‐lipoproteintriacylglycerol secretion by the perivenous zone of the liver. Nevertheless, no zonal differences were observed between control and ethanol‐fed animals with respect to the effects of acute doses of ethanol and acetaldehyde on lipid metabolism. In conclusion, our results show that chronic ethanol intake produces important alterations in the acinar distribution of the different fatty acid—metabolizing pathways. (HEPATOLOGY 1990; 12:1098–1105).
Hypothesis-Driven Specialization of Gene Expression Association Rules

This paper focuses on analyzing patterns mined from gene expression data. Whether a particular gene is "turned on" (expressed) or not is controlled by particular DNA se- quences (motifs). Multiple motifs are commonly involved in the expression of each gene, and the position and spacing of these motifs may be important. However, most available computational tools consider the importance only of indi- vidual motifs. We designed and developed an interactive tool that uses genetic data to derive association rules in- volving multiple motifs of possible significance in gene ex- pression. Genetic data are visualized in the context of a rule to facilitate rule specialization according to biological hypotheses regarding order, position, and spacing of mo- tifs. Different measures of interestingness (confidence, lift, p-value) are used to evaluate the rules' significance.
The embodiment of the categorical imperative

Am I enjoined and moved by a sense of moral responsibility that, prior to consciousness, prior to volition, has always already informed and predisposed the very nature of my flesh? How could we account for this experience without recognizing that it is the flesh that first bears the order of the moral law? This study undertakes a hermeneutical reading of some texts in which the question of the embodiment of the categorical imperative, the responsibility enjoined by the procedural form of the moral law, is introduced. It is hoped that this reading will contribute to our understanding of the body of experience, the so-called body-subject, showing the body to be not only an object-body, not only, as in the work of Foucault, a material substratum for the application of power, but also, as Levinas thought, the primordial bearer of a certain rudimentary moral compass, at the very heart of which there lies, if only deeply encrypted, the categorical assignment of the moral law. Thus, the human body is not, as some postmodern writers contend, a totally unruly, uncivilized nature without any implicit order of its own, but is a first nature always already disposed, if only in a preliminary and rudimentary way, to bear the moral development that society requires us to undertake.
An autism cohort study of cobalt levels following vitamin B12 injections

The effects of methylcobalamin (vitamin B12) injection (75 µg kg−1) on cobalt levels in autism spectrum disorders (ASDs) and potential toxic effects of cobalt on human neurons were evaluated. A cohort of ASDs (n = 72) presenting to the Genetic Centers of America were evaluated for the frequency of methylcobalamin injections and cobalt levels using Laboratory Corporation of America (LabCorp) testing. Potential toxic effects of cobalt (cobalt(II) nitrate hexahydrate) to human neurons grown in vitro were evaluated. Methylcobalamin injections significantly increased the mean levels of plasma cobalt (6.83-fold) and urinary cobalt (51-fold) in comparison to unexposed subjects, and significant positive correlations were found between the frequency of methylcobalamin injections and the levels of plasma and urinary cobalt (injections every second day induced cobalt levels in excess of the LabCorp cobalt occupational maximum exposure limits). The LC50 in human neurons following 24 h incubation with cobalt is 559 µM. Research must be conducted to determine optimal therapeutic methylcobalamin doses.
Factors Determining the Outcome of Hematopoietic Stem Cell Transplantation in Patients With Acute Lymphoblastic Leukemia at King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

Medical records of 82 patients with acute lymphoblastic leukemia (ALL) who underwent hematopoietic cell transplantation (HCT) at our institution from 2005 to 2011 were reviewed. Forty-five patients were male (54.8%). The median age at HCT was 7.46 years (range, 0.98 to 14.31 y), the median time to HCT after diagnosis was 12.56 months. Ten patients were below the age of 1 year (12%). All patients were in complete remission at the time of HCT. In 83 transplants, 64 patients received HCT from human leukocyte antigen-identical–related donors and 19 from other donors. Stem cell source was bone marrow in 65 (78%) and cord blood in 18 (22%). Five-year overall survival was 58.8% and event-free survival was 54.3%. The cumulative incidence of acute graft versus host disease was 4.8%±2.3% and of chronic graft versus host disease was 8.9%±3.2%. The median time to absolute neutrophil count and platelet recovery was 17 days (range, 12 to 43 d) and 28 days (range, 15 to 98 d), respectively. One patient acquired CMV infection after transplant. No one developed venoocclusive disease, hemorrhagic cystitis, or other complication. Patient’s age at diagnosis, sex, donor’s human leukocyte antigen status and sex, source of transplant and complete remission status at HCT did not affect overall survival and event-free survival. Our results show a favorable outcome to HCT for acute lymphoblastic leukemia patients comparable to published data, and no single factor was associated with superior outcome.
Molecular Mechanisms of the Biological Clock in Cultured Fibroblasts

In mammals, the central circadian pacemaker resides in the hypothalamic suprachiasmatic nucleus (SCN), but circadian oscillators also exist in peripheral tissues. Here, using wild-type andcryptochrome (mCry)–deficient cell lines derived from mCry mutant mice, we show that the peripheral oscillator in cultured fibroblasts is identical to the oscillator in the SCN in (i) temporal expression profiles of all known clock genes, (ii) the phase of the various mRNA rhythms (i.e., antiphase oscillation of Bmal1 and mPer genes), (iii) the delay between maximum mRNA levels and appearance of nuclear mPER1 and mPER2 protein, (iv) the inability to produce oscillations in the absence of functionalmCry genes, and (v) the control of period length by mCRY proteins.
GitHub's big data adaptor: an eclipse plugin

The data of GitHub, the most popular code-sharing platform, fits the characteristics of "big data" (Volume, Variety and Velocity). To facilitate studies on this huge GitHub data volume, the GHTorrent web-site publishes a MYSQL dump of (some) GitHub data quarterly. Unfortunately, developers using these published data dumps face challenges with respect to the time required to parse and ingest the data, the space required to store it, and the latency of their queries. To help address these challenges, we developed a data adaptor as an Eclipse plugin, which efficiently handles this dump. The plugin offers an interactive interface through which users can explore and select any field in any table. After extracting the data selected by the user, the parser exports it in easy-to-use spreadsheets. We hope that using this plugin will facilitate further studies on the GitHub data as a whole.
Introduction to Alfred Lorenzer's paper ‘Language, life praxis and scenic understanding in psychoanalytic therapy’

In the contribution reproduced here, which dates from 1983, Alfred Lorenzer develops his conception of psychoanalytic knowledge and of the method whereby it is obtained. It forms part of the more comprehensive project to establish a new metatheory of psychoanalysis, centred on the scenic understanding of the unconscious. After a short biographical sketch, I shall describe by way of introduction the fundamentals of his metatheory of psychoanalysis. Alfred Lorenzer was born in 1922; following his medical studies, he trained as a psychiatrist with Ernst Kretschmer at T€ ubingen University’s clinic for nervous diseases. He completed his psychoanalytic training at Stuttgart’s institute of psychotherapy and in Alexander Mitscherlich’s psychosomatic clinic at the University of Heidelberg, and then worked at the Sigmund Freud Institute in Frankfurt, which was headed by Mitscherlich. He was a training analyst in the German Psychoanalytical Association (DPV). In 1971 he became Professor of Social Psychology at the University of Bremen, moving in 1974 to Frankfurt University, in whose sociology faculty he held a chair in the theory of socialization. A serious illness caused him to give up his scientific and psychoanalytic activity in 1991. He died in 2002. On the basis of the Critical Theory due to Horkheimer and Adorno, an extraordinarily stimulating and fertile culture of discussion on such issues as scientific methodology in the social sciences, scientific objectivity, and the hermeneutic understanding of meaning had arisen in 1960s Frankfurt, embracing psychoanalysis too as a theory. The resulting dialogue between social scientists and psychoanalysts led to fruitful advances within the discipline of psychoanalysis. One of these was Alfred Lorenzer’s project for a new metatheory of psychoanalysis. Lorenzer was one of the great theorists of German psychoanalysis. His scientific approach was concentrated on gaining a detailed understanding of the formation of knowledge in psychoanalysis and on placing psychoanalysis in the context of a theory of society. From the beginning of his scientific career, he was concerned with the particularity of psychoanalytic understanding. His concept of scenic understanding enabled him to overcome the limitations of logical and psychologi-
An approach to a cross layer-based QoE improvement for MANET routing protocols

Currently, multimedia communications are monopolizing Internet traffic. These services present highly demanding real-time requirements that need great bandwidths in order to provide acceptable quality levels. Meanwhile, the variety of network architectures employed by final users to access these contents is wider and wider. One of the most attractive access networks due to its ease-of-deployment and decentralized architecture is the Mobile Ad-hoc NETworks (MANETs). The inherent dynamic nature of these networks entails the use of appropriate routing protocols in order to obtain good performance in the services supported by the system. In this work, we focus on evaluating the performance of the novel routing protocol Better Approach To Mobile Ad-hoc Networking (BATMAN) and the widely extended IETF experimental drafts Optimized Link State Routing (OLSR) and Ad hoc On-Demand Distance Vector (AODV) protocols supporting video traffic. The results obtained from a chain-topology network have been improved in terms of Quality of Experience (QoE) by means of different modifications at different OSI layers. We have found out that each protocol presents low performance in different scenarios that can be enhanced by means of the proposed techniques. As we show in this work, taking a proper action in the right OSI layer permits an improvement on the multimedia traffic support in MANETs.
Control of carbamyl phosphate synthesis in Salmonella typhimurium.

Abstract Carbamyl phosphate synthetase from Salmonella typhimurium LT-2 has been purified 320-fold; the modulation of enzyme activity by substrate concentration, effectors, and the effect of temperature on this modulation have been studied. Uridine phosphate inhibits the enzymic reaction; ornithine reverses this inhibition and also activates the enzyme in the absence of UMP by decreasing the apparent Km for ATP. The stimulation by ornithine is greater at low temperature, whereas the inhibitory effect of UMP is equal at high and low temperatures. Studies with various strains blocked by mutation in steps which interconvert cytosineand uracil-containing compounds have established that the pyrimidine repressor of the synthesis of carbamyl phosphate synthetase is a cytosine-containing compound.
Teorías relacionales sobre la estructura del espacio-tiempo: física, filosofía, teología

We present some modern theories on the structure of space-time that can be classified as relational theories in the direction of Leibniz’s ontology. In particular we summarize the Leibniz’s position against Newton and Clarke on the nature of space-time, Penrose’s model of spin networks, Heisenberg’s fundamental equation for the unification of elementary particles, Finkelstein’s space-time code, Weizsacker’s urs theory that unifies the postulates of quantum mechanics and the theory of relativity, Sorkin’s causal sets, Markopoulou’s quantum causal histories, Markopoulou and Smolin’s causal spin foams, in the last three of which the principle of causality has been introduced. In order to analyze the nature of space-time, we consider three levels of knowledge —observational, theoretical and ontological— to which the different models can be ascribed. Following similar approach to the models mentioned in the first sections, we present our theoretical model of the structure of the space-time, some physical applications and the ontological interpretation of the model. In order to implement the above models with theological aspects we present in the last sections two theologians, Pannenberg and Torrance, who have made explicit analysis of the nature of space-time from a relational point of view. Following their expositions we have presented, after some epistemological presuppositions, the connection between the Creation and the rationality of God through the structure of space-time and the communication of God to the creatures in the Incarnation through the same structure.
Identificação do perfil da ionosfera utilizando lógica nebulosa: parte I

A ionossonda digital e um dos instrumentos que mede a densidade eletronica da baixa ionosfera, atraves de radio frequencia, obtendo como resultado espectros de frequencia em funcao da altura chamados ionogramas. A ionosfera pode ser analisada estudando-se alguns parâmetros criticos que indicam a altura da base da camada F(h'F), a frequencia com o pico de densidade eletronica na camada F (foF2) e a altura do pico de densidade eletronica na camada F(hpF2). Ate o presente momento, estes parâmetros sao extraidos dos ionogramas de uma forma manual e dependente da interpretacao de um analista. Devido a grande quantidade de dados coletados pelas ionossondas necessita-se de uma automatizacao deste processo de coleta e analise. Este trabalho propoe um modelo de apoio a decisao para o processo de analise dos dados coletados por ionossondas com o proposito de elevar a capacidade de compilacao dos dados ionosfericos. A implementacao do modelo de apoio a decisao foi estruturada em duas partes: a primeira parte propoe uma abordagem de logica nebulosa para o problema de associacao de dados, considerando as diferentes camadas ionosfericas. A segunda parte propoe o emprego de relacao nebulosa como estrutura para a construcao das regras de um sistema nebuloso especialista. Este trabalho apresenta apenas a primeira parte do modelo.
Performance analysis of mobile wireless overlay networks based on application services

An overlay network constructed from underlaying wireless base networks has become of great interest to researchers of the integration of heterogeneous networks under a global perspective. Overlaying can be implemented either directly in the network layer or in the application layer. The application layer overlay is becoming more attractive due to its flexibility and expanded functionalities at the higher layer. However, the main cost paid for these is the relative delay penalty (RDP). The paper prepares an overlay tree and makes a comprehensive analysis between network services and application services. The various metrics for application overlay networks are discussed, based on simulation results.
EEG Alpha Rhythm and Glucose Metabolic Rate in the Thalamus in Schizophrenia

Positron emission tomography with uptake of [18F]fluorodeoxyglucose (FDG) and quantitative EEG were simultaneously performed in 18 medication-free patients with schizophrenia and in 13 normal volunteers. Subjects performed the Continuous Performance Task (CPT) during FDG uptake. Correlations were calculated between alpha power during the CPT and glucose metabolic rate (GMR) in thalamic regions and between alpha power during the CPT and GMR in occipital cortices. Regression analyses were used to describe the prediction of GMR in the occipital cortices and in the thalamic regions of occipital alpha power. In normal controls, we found (1) significant negative correlations between absolute alpha power and GMR in the left occipital cortex, (2) significant positive correlations between normalized alpha power and GMR in the right and left lateral thalamus and (3) combined effects of GMR in the thalamic regions and the occipital cortices on alpha power, which accounted for 98% of the variance of alpha power. In patients with schizophrenia, we found no significant correlations between alpha power and GMR in the occipital cortices or between alpha power and GMR in the thalamic regions. Correlation coefficients between absolute alpha power and GMR in the left occipital cortex and between normalized alpha power and GMR in the left lateral thalamus were significantly different in normal subjects compared to schizophrenic patients. The present findings provide evidence for involvement of the thalamus in the generation of alpha rhythm in humans. Furthermore, the present results suggest differences in thalamocortical circuits between normal controls and schizophrenic subjects.
A homozygous SLITRK6 nonsense mutation is associated with progressive auditory neuropathy in humans

SLITRK family proteins control neurite outgrowth and regulate synaptic development. In mice, Slitrk6 plays a role in the survival and innervation of sensory neurons in the inner ear, vestibular apparatus, and retina, and also influences axial eye length. We provide the first detailed description of the auditory phenotype in humans with recessive SLITRK6 deficiency.
Effectiveness of the Liverpool care pathway for the dying in residential care homes: An exploratory, controlled before-and-after study

Background: Clinical pathways aim to ensure that individuals receive appropriate evidence-based care and interventions, with the Liverpool Care Pathway for the Dying Patient focusing on end of life. However, controlled studies of the Liverpool Care Pathway for the Dying Patient, particularly outside of cancer settings, are lacking. Aim: To compare the effects of the Liverpool Care Pathway for the Dying Patient and usual care on patients’ symptom distress and well-being during the last days of life, in residential care homes. Design: Exploratory, controlled before-and-after study. During a 15-month baseline, usual care was carried out in two areas. During the following 15-months, usual care continued in the control area, while residential care home staff implemented Liverpool Care Pathway for the Dying Patient use in the intervention area. The intervention was evaluated by family members completing retrospective symptom assessments after the patient’s death, using the Edmonton Symptom Assessment System and Views of Informal Carers – Evaluation of Services. Settings/participants: Patients who died at all 19 residential care homes in one municipality in Sweden. Results: Shortness of breath (estimate = −2.46; 95% confidence interval = −4.43 to −0.49) and nausea (estimate = −1.83; 95% confidence interval = −3.12 to −0.54) were significantly reduced in Edmonton Symptom Assessment System in patients in the intervention compared to the control area. A statistically significant improvement in shortness of breath was also found on the Views of Informal Carers – Evaluation of Services item (estimate = −0.47; 95% confidence interval = −0.85 to −0.08). Conclusion: When implemented with adequate staff training and support, the Liverpool Care Pathway for the Dying Patient may be a useful tool for providing end-of-life care of elderly people at the end of life in non-cancer settings.