Miracle-dz/UniFAR-FTUs huggingface dataset:
Synergy and Cross-Tolerance Between Toll-Like Receptor (TLR) 2- and TLR4-Mediated Signaling Pathways1

A family of Toll-like receptor (TLR) mediates the cellular response to bacterial cell wall components; murine TLR2 and TLR4 recognize mycoplasmal lipopeptides (macrophage-activating lipopeptides, 2 kDa (MALP-2)) and LPS, respectively. Costimulation of mouse peritoneal macrophages with MALP-2 and LPS results in a marked increase in TNF-α production, showing the synergy between TLR2- and TLR4-mediated signaling pathways. Macrophages pretreated with LPS show hyporesponsiveness to the second LPS stimulation, termed LPS tolerance. The LPS tolerance has recently been shown to be primarily due to the down-regulation of surface expression of the TLR4-MD2 complex. When macrophages were treated with MALP-2, the cells showed hyporesponsiveness to the second MALP-2 stimulation, like LPS tolerance. Furthermore, macrophages pretreated with MALP-2 showed reduced production of TNF-α in response to LPS. LPS-induced activation of both NF-κB and c-Jun NH2-terminal kinase was severely impaired in MALP-2-pretreated cells. However, MALP-2-pretreated macrophages did not show any reduction in surface expression of the TLR4-MD2 complex. These findings indicate that LPS-induced LPS tolerance mainly occurs through the down-regulation of surface expression of the TLR4-MD2 complex; in contrast, MALP-2-induced LPS tolerance is due to modulation of the downstream cytoplasmic signaling pathways.
Suggest Solutions for Diffusion and Implementation of Activity-Based Costing In Vietnam

Activity-Based Costing (ABC) was developed by Robert S. Kaplan in the mid-1980s and up to now the academics, researchers as well as accounting practitioners have perceived it as the normative appropriate cost system. It has been considered as a method to overcome the shortcomings of the traditional costing. However, the application the new method as ABC is a challenge for Vietnamese companies because most of them have used traditional costing for calculating product cost. Changing from traditional costing system to ABC system will face many difficulties. In the fierce competitive business environment, along with the growth of Vietnamese companies – it means that the production of product diversity, machinery and equipment invested more and more modernly and automatically, leads indirect costs increasing and major proportion in total costs. These characteristics are suitable for the application of ABC method to calculate product cost and provide information for management. In addition, increasing of pressure from consumers and competitors force Vietnamese businesses to find a more modern approach to help them achieve advantage competition and increase profitability. Thus, application of ABC method is need for Vietnamese companies. This paper attempts to find obstacles to ABC application and suggests solutions for ABC diffusion and implementation in Vietnam.
Who are the top contributors in a MOOC? Relating participants' performance and contributions

The role of social tools in massive open online courses MOOCs is essential as they connect participants. Of all the participants in an MOOC, top contributors are the ones who more actively contribute via social tools. This article analyses and reports empirical data from five different social tools pertaining to an actual MOOC to characterize top contributors and provide some insights aimed at facilitating their early detection. The results of this analysis show that top contributors have better final scores than the rest. In addition, there is a moderate positive correlation between participants' overall performance measured in terms of final scores and the number of posts submitted to the five social tools. This article also studies the effect of participants' gender and scores as factors that can be used for the early detection of top contributors. The analysis shows that gender is not a good predictor and that taking the scores of the first assessment activities of each type test and peer assessment in the case study results in a prediction that is not substantially improved by adding subsequent activities. Finally, better predictions based on scores are obtained for aggregate contributions in the five social tools than for individual contributions in each social tool.
Barcode Medication Administration Work-Arounds: A Systematic Review and Implications for Nurse Executives

Safe medication administration is necessary to ensure quality healthcare. Barcode medication administration systems were developed to reduce drug administration errors and the related costs and improve patient safety. Work-arounds created by nurses in the execution of the required processes can lead to unintended consequences, including errors. This article provides a systematic review of the literature associated with barcoded medication administration and work-arounds and suggests interventions that should be adopted by nurse executives to ensure medication safety.
Characterization and Diversity of Novel Pif/Harbinger Dna Transposons in Brassica Genomes

Among DNA transposons, PIF/Harbinger is most recently identified superfamily characterized by 3 bp target site duplications (TSDs), flanked by 14-45 bp terminal inverted repeats (TIRs) and displaying DDD or DDE domain displaying transposase. Their autonomous elements contain two open reading frames, ORF1 and ORF2 encoding superfamily specific transposase and DNA-binding domain. Harbinger DNA transposons are recently identified in few plants. In present study, computational and molecular approaches were used for the identification of 8 Harbinger transposons, of which only 2 were complete with putative transposase, while rest 6 lack transposase and are considered as defective or non-autonomous elements. They ranged in size from 0.5-4 kb with 3 bp TSDs, 15-42 bp TIRs and internal AT rich regions. The PCR amplification of Brassica Harbinger transposase revealed diversity and ancient nature of these elements. The amplification polymorphism of some non-autonomous Harbingers showed species specific distribution. Phylogenetic analyses of transposase clustered them into two clades (monocot and dicot) and five sub-clades. The Brassica, Arabidopsis and Malus transposase clustered into genera specific sub-clades; although a lot of homology in transposase was observed. The multiple sequence alignment of Brassica and related transposase showed homology in five conserved blocks. The DD35E triad and sequences showed similarity to already known Pong-like or Arabidopsis ATISI12 Harbinger transposase in contrast to other transposase having DD47E or DD48E motifs. The present study will be helpful in the characterization of Harbingers, their structural diversity in related genera and Harbinger based molecular markers for varietal/lines identifications.
Co‐stimulation‐dependent activation of a JNK‐kinase in T lymphocytes

Previously we implicated c‐Jun N‐terminal kinase (JNK) as an element that is involved in signal integration during co‐stimulation of T lymphocytes. This pathway has now been traced to an upper level, comprising MAPKK SEK1/MKK4/JNKK1 which, similarly to JNK, must receive input both from the TCR and CD28. A large portion of this input is probably integrated at the level of the Rho‐family protein CDC42 which, here, activates SEK1 and JNK to the level reached by TCR and CD28 stimulation. We have identified another putative SEK/JNK pathway regulator, PKCθ, which in contrast to CDC42, activates SEK and JNK maximally only in conjunction with a calcium signal delivered through calcineurin. Signals originating at the TCR and CD28 may travel down the JNK pathway via PKCθ, calcineurin, CDC42, MEKK1 and SEK1.
GDF3, a BMP inhibitor, regulates cell fate in stem cells and early embryos

The TGFβ superfamily of ligands plays key functions in development and disease. In both human and mouse embryonic stem cells, a member of this family, GDF3, is specifically expressed in the pluripotent state. We show that GDF3 is an inhibitor of its own subfamily, blocks classic BMP signaling in multiple contexts, interacts with BMP proteins and is expressed specifically in the node during gastrulation in a pattern consistent with BMP inhibition. Furthermore, we use gain- and reduction-of-function to show that in a species-specific manner, GDF3 regulates both of the two major characteristics of embryonic stem cells: the ability to maintain the undifferentiated state and the ability to differentiate into the full spectrum of cell types.
Personalized Microblog Sentiment Classification via Multi-Task Learning

Microblog sentiment classification is an interesting and important research topic with wide applications. Traditional microblog sentiment classification methods usually use a single model to classify the messages from different users and omit individuality. However, microblogging users frequently embed their personal character, opinion bias and language habits into their messages, and the same word may convey different sentiments in messages posted by different users. In this paper, we propose a personalized approach for microblog sentiment classification. In our approach, each user has a personalized sentiment classifier, which is decomposed into two components, a global one and a user-specific one. Our approach can capture the individual personality and at the same time leverage the common sentiment knowledge shared by all users. The personalized sentiment classifiers of massive users are trained in a collaborative way based on multi-task learning to handle the data sparseness problem. In addition, we incorporate users' social relations into our model to strengthen the learning of the personalized models. Moreover, we propose a distributed optimization algorithm to solve our model in parallel. Experiments on two real-world microblog sentiment datasets validate that our approach can improve microblog sentiment classification accuracy effectively and efficiently.
Analytic Studies in Plant Respiration

selves constitute a somewhat inadequate and elementary review. Anesthesia, though generally considered a specialty of its own, is an adjuvant to operative treatments, and the skillful review presented here should be of interest to all surgeons; a companion presentation is the very pertinent presentation concerning surgical patients with cardiac, diabetic, or renal handicaps. The discussion of thrombosis and embolism is considered to be one of the most worthwhile portions of the monograph. The author has taken a very fundamental and questioning attitude toward current concepts and provides the thoughtful reader with much to consider in basically altered physiology and biochemistry. The highly specialized topics of problems related to certain areas of operative treatment are handled in manners varying from excellence to mediocrity. The significant ones appear to be those concerned with cardiac arrest, prevention 'and treatment of surgical infections, steroids in the management of advanced carcinoma, postoperative pulmonary complications, biliary tract operations, acute intestinal obstruction, lesions of the colon and rectum, urinary tract complications, and patients with multiple injuries. In summary, the monograph is generally an excellent one for general review reading and should be available as references for all physicians with a surgical interest.
Ciencias cognitivas y taichi

El present article esta dedicat a establir ponts entre les ciencies cognitives (mes concretament, la visio enactiva de la cognicio), i la practica del tai-txi, provinent de la Xina. Per a aixo, dedicarem la primera part a fer una breu analisi de la visio enactiva de la cognicio, contraposant a la visio cognitivista. En el segon apartat, s'oferira una interpretacio de l'essencia i practica del tai-txi, a la llum dels conceptes apareguts en el primer apartat. En tercer lloc, hi haura un apartat dedicat a explicar les consequencies practiques i etiques de l'aprenentatge de tai-txi, i l'ultima part de l'article estara dedicada a l'us de combinacions conceptuals i ancoratges materials en l'aprenentatge i transmissio de coneixement del tai-txi.
The Interplay between Immigration and Local Population Dynamics in Metapopulations

Stochastic models of closed populations predict eventual extinction with certainty. Consequently, their behavior is often characterized by the quasi-stationary state, i.e. the long-term distribution of population sizes conditional on non-extinction. In contrast, models which allow for immigration exhibit a regular stationary state. At the limit of a low immigration rate, a population is expected to alternate between three states: the quasi-stationary state of a closed population, the extinction state, and the transient phase during which a newly arrived immigrant either establishes a new population or fails to do so. We develop this argument into a simple and intuitive framework that can be used to assess the effect of immigration in a general class of population models. We exemplify the framework for models in which immigrants arrive either singly or in groups, for models with an Allee effect, for models with environmental stochasticity, and for models leading to metapopulation dynamics.
Aplicação de metaheurísticas na abordagem do problema de otimização do ciclo de montagem de uma insersora automática de componentes

Este artigo apresenta a aplicacao de meta-heuristicas na abordagem do problema de otimizacao do ciclo de operacao de uma insersora automatica de componentes (pick-and-place) em maquinas do tipo multicabecas. Um algoritmo hibrido foi desenvolvido utilizando as meta-heuristicas Busca Tabu e Algoritmo Genetico. Na abordagem do problema sao considerados os problemas de escalonamento das ferramentas, de escalonamento da sequencia de insercao de componentes e, por fim, o problema da alocacao dos componentes no alimentador. Como resultados foram obtidas solucoes de boa qualidade aplicaveis a sistemas reais.
Insect venom immunotherapy induces interleukin‐10 production and a Th2‐to‐Th1 shift, and changes surface marker expression in venom‐allergic subjects

The current study was carried out to elucidate the immunoregulatory changes induced by venom immunotherapy (VIT) in bee or wasp allergic subjects. All subjects included in this study had a history of severe systemic allergic reactions to stings of the respective insect as well as positive skin tests with the respective venom or venom‐specific IgE in the sera. Parameters assessed in peripheral blood mononuclear cells (PBMC) before and after initiation of VIT (rush therapy reaching a maintenance dose of 100 μg venom injected subcutaneously within 1 week) were expression of CD3, CD4, CD8, CD45RA, CD45R0, interleukin (IL)‐2 receptor (R)α, IL‐4R, IL‐12R, FcσRII, CD40, and CD40 ligand (CD40L), cells producing interferon (IFN)‐γ and IL‐10 after stimulation with phorbol 12‐myristate 13‐acetate + ionomycin in the presence of monensin measured by flow cytometry; secretion of IFN‐γ, IL‐4, and IL‐10 measured by ELISA (IFN‐γ and IL‐10 were additionally measured by PCR), and proliferation after stimulation with the respective venom. Significant decreases were observed after VIT for proliferative response to venom and venom + IL‐4, IL‐4 secretion, FcσRII, CD40, and CD40L expression. Significant increases were observed after VIT for IFN‐γ concerning the amount secreted and the number of producing cells, and IL‐10. IL‐10 was mainly produced by CD4+ cells that were negative for IFN‐γ, but some double‐positive (IL‐10 and IFN‐γ) cells were always detected. Addition of blocking anti‐IL‐10 antibodies, but not isotype control antibodies, prevented down‐regulation of proliferation (but not IL‐4 secretion) and further enhanced IFN‐γ secretion after VIT. These data indicate that in insect venom allergic subjects, VIT not only induces a rapid shift in cytokine expression from Th2 to Th1 cytokines, but also leads to induction of the immunosuppressive cytokine IL‐10, which may be important for the limitation of potentially harmful allergen‐specific Th1 responses. The described changes in cytokine expression may be responsible for subsequent increases in allergen‐specific IgG and decreases in IgE production, as well as suppressive activity observed in earlier studies.
The Strategic Approach to Exploration Review on TQM and Lean Production

The aim of this paper is to explore similarities and differences between TQM and Lean Production with an emphasis on Lean strategy approach. This paper investigates the related literature of various studies, analyzes, and finally reviews them systematically. This study finds that, although Lean and TQM both aim to improve quality, TQM reaches a certain point or stage at which no more improvements can be made. Lean, however, focuses on taking quality improvement to the next level. It is clear that Lean journey is deeper and more extensive in comparative to TQM Journey. Lean production evolution is Lean thinking; Lean was reconsidered to this renown. And, the result of this research discloses that TQM and Lean Production have many concepts in common. However, based on Lean strategies; TQM, similar to many improvement approaches, can be a tool to support and create synergy for making a more competitive factors market place amid firms. JEL Classifications: L15, M11, O14, O33
A new perspective of integrative genome-wide association analysis considering trans eSNP effect

Most loci discovered through genome-wide association analyses are predicted to affect gene expression, the integrative approach of genome-wide analysis with gene expression data is becoming essential procedure for discovering genetic effect of disease development. Many studies have been performed to discover significant SNP-gene associations, but most of them are limited to consider only cis-associations and neglect trans-territory. In this study, we explored the effect of trans-eSNP associations that may underlie the alternation of gene expressions. Through the integrative genome-wide association analysis considering the entire SNP-gene associations, we identified numerous trans associations which are significantly associated with gene expression, even more than cis associations in quantity and significance. Our findings revealed the necessity of reconsidering trans-association effect from integrative genome-wide association analysis and provided novel insights to find undiscovered genetic causalities.
Content adaptor selection models in Adaptation Management Framework

Pervasive devices possess restricted capabilities in terms of processing, information display and network data rates due to their mobile nature. Therefore in order to provide content to users with pervasive devices, the quality of the media presentation often needs to be adjusted according the different characteristics of those devices, and it is not efficient for content and service providers to provide all sort of contents in advanced. That indicates the great importance of adaptation in pervasive computing environment. Adaptation Management Framework (AMF) has been proposed to provide an environment in which the content/services are personalized to the user's preferences automatically. In this paper, we look into one major complication in the design of the AMF, that is to select and combine appropriate adaptation operations as well as their concrete implementations which is called Adaptation Mechanisms. We proposed the use of two selection algorithm methods to fulfill the tasks. Their performances are evaluated and compared with respect to effectiveness and efficiency.
The effects of resistance exercise on skeletal muscle abnormalities in patients with advanced heart failure.

Resistance exercise increases muscular strength and endurance, which prevents injuries associated with musculoskeletal disorders, favorably alters muscle fiber type distribution, and up-regulates the genetic expression of certain enzymes seen in dysfunctional skeletal muscles. Although the benefits of resistance exercise are well documented in the literature, this form of exercise is not routinely recommended for patients with heart failure for fear of symptom exacerbation, and because of poor understanding of how best to prescribe this type of exercise. Because muscle atrophy and deconditioning states are common findings in patients with heart failure, these patients stand to benefit substantially from resistance training because this type of physical activity results in functional adaptations in the neuromuscular system. This article addresses changes in skeletal muscle pathophysiology that occur in patients with heart failure and the potential role resistance training may play in reversing this sequela, and recommends a weight lifting exercise prescription for these patients.
Blood lactate levels of decathletes during competition.

There are many detailed physiological profiles of athletes who participate in a wide variety of sporting activities but few data have been obtained on decathletes. This study defines some physiological characteristics of these athletes and measures capillary lactate concentrations [La(b)] during a laboratory test of progressive maximal exhaustion and the different events during competition. The treadmill test is similar to the 100 m, 400 m and 1500 m in terms of [La(b)] accumulation but only similar to the 1500 m in terms of velocity. The 400 m is the most demanding event with the greatest blood lactate accumulation (mean(s.d.) 16.38(2.36) mmol l-1). The [La(b)] at the end of the 110 m hurdles is significantly lower than in any other racing events (mean(s.d.) 6.96(1.32) mmol l-1) compared with mean(s.d.) 12.14(2.87) and mean(s.d.) 11.44(2.16) for the 100 m and 1500 m respectively. The [La(b)] after the long jump, the high jump and the pole vault are not significantly different (mean(s.d.) 5.30(2.23), 4.64(1.39) and 5.36(1.34) mmol l-1) respectively).
Hybrid Excavator Power System Controller Design Based on Fuzzy Control

Controller of hybrid excavator power system was designed with control target was to improve diesel engine fuel efficiency and decrease shaft rotate speed fluctuation. Controller input parameters were set as hydraulic pump required torque, hydraulic pump rotate speed and battery SOC. Controller output parameters were set as diesel engine output torque and motor torque. Diesel engine output torque was obtained according to its load characteristic curves. Control method of diesel engine throttle based on Fuzzy control was proposed. Power system working pattern switch rules were introduced. Simulation model of controller performance based on MATLAB was established. Controller working performance simulations in mining condition and formation condition were simulated. Simulation results show that hydraulic pump required torque is provided by diesel engine and motor in mining condition. Power system required torque is provided by motor in formation condition. Battery SOC curve is changed according to designed control rules. Diesel engine shaft rotate speed is almost constant during the whole working process. Diesel engine fuel consumption rate is constant in mining condition and is almost zero in formation condition.