Miracle-dz/UniFAR-FTUs huggingface dataset:
Fully Human Monoclonal Antibody Directed to Proteolytic Cleavage Site in Severe Acute Respiratory Syndrome (SARS) Coronavirus S Protein Neutralizes the Virus in a Rhesus Macaque SARS Model

Abstract Background. There is still no effective method to prevent or treat severe acute respiratory syndrome (SARS), which is caused by SARS coronavirus (CoV). In the present study, we evaluated the efficacy of a fully human monoclonal antibody capable of neutralizing SARS-CoV in vitro in a Rhesus macaque model of SARS. Methods. The antibody 5H10 was obtained by vaccination of KM mice bearing human immunoglobulin genes with Escherichiacoli–producing recombinant peptide containing the dominant epitope of the viral spike protein found in convalescent serum samples from patients with SARS. Results. 5H10, which recognized the same epitope that is also a cleavage site critical for the entry of SARS-CoV into host cells, inhibited propagation of the virus and pathological changes found in Rhesus macaques infected with the virus through the nasal route. In addition, we analyzed the mode of action of 5H10, and the results suggested that 5H10 inhibited fusion between the virus envelope and host cell membrane. 5H10 has potential for use in prevention and treatment of SARS if it reemerges. Conclusions. This study represents a platform to produce fully human antibodies against emerging infectious diseases in a timely and safe manner.
ScienceDirect Eleventh International Multi-Conference on Information Processing-2015 ( IMCIP-2015 ) Cross-Lingual Preposition Disambiguation for Machine Translation

This paper presents a supervised prepositional ambiguity resolution method for machine translation models in which the target language is Tamil and source language is English. We restrict our transfer ambiguity resolution problem with few prepositions only. This resolution method is based on supervised models which exploit collocation occurrences and linguistic information as features. This attempt will rectify the challenges in handling prepositions in English to Tamil automatic translation system. The preliminary results obtained from the evaluation shows that the proposed method is suitable for preposition resolution problem. © 2015 The Authors. Published by Elsevier B.V. Peer-review under responsibility of organizing committee of the Eleventh International Multi-Conference on Information Processing-2015 (IMCIP-2015).
Modelling of Stent Deployment and Deformation in Diseased Arteries by Considering Vessel Anisotropy Modelling of Stent Deployment and Deformation in Diseased Arteries by Considering Vessel Anisotropy

In this paper, finite element simulation of stent deployment was carried out using an anisotropic model for the artery, consisting of three individual tissue layers, i.e., intima, media and adventitia. Each layer was modelled as a hyperelastic anisotropic material described by the Holzapfel-Gasser-Ogden (HGO) model. The model parameters were calibrated against the experimental stress-stretch responses in both circumferential and longitudinal directions. The results showed that, at the peak pressure, stent expansion obtained using the anisotropic model was much reduced when compared to that obtained using the isotropic model. However, after deflation, the finally achieved diameter for the anisotropic model is comparable to that for the isotropic model, due to the significant reduction in recoiling for the anisotropic model. Also, the anisotropic model generated slightly higher levels of stress in the arteryplaque system than the isotropic model. For the isotropic model, the high-level stresses were found mainly on the plaque, while, for the anisotropic model, both the intima layer and the plaque experienced high-level stresses. The media and adventitia layers had lower stress levels due to their relatively softer stress-strain response in the circumferential direction as well as limited deformation. Following deployment, deformation of the stent was also modelled by applying relevant biomechanical forces, such as bending and radial compression, to the stent-artery system. The results were utilised to interpret the mechanical performance of stent after deployment.
Brazilian Journal of Chemical Engineering OBSERVANCE OF POLYMORPHIC BEHAVIOUR DURING DISSOLUTION OF INSULIN AND LYSOZYME

Although protein crystallization is a unit operation with potentially high separation factors, it has not been widely used in industry. Protein crystallization studies and practices have hitherto been largely limited to crystallography protocols. Knowledge of the behaviour of protein in solution would help to overcome empiric limitations in protein crystallisation. Thus, dissolution of porcine insulin and hen egg white lysozyme was studied and an unusual variation in solute concentration, with a concentration peak for short dissolution times, was verified. Polymorphic behaviour of protein in solution was observed, which altered physical properties such as solubility.
Exposure of rabbit lens to hyperbaric oxygen in vitro: regional effects on GSH level.

Previous studies have indicated that in vivo exposure to hyperbaric O2 may be associated with the development of nuclear cataract. In the present work, in vitro effects of hyperbaric O2 on rabbit lenses were investigated following culture of the lenses in an atmosphere of 99% O2 at pressures ranging between 1 and 100 atm. Treatment with O2 resulted in a significant decrease in the level of reduced glutathione (GSH) in the lenses even at the lower pressures studied (less than 8 atm). At 100 atm O2 the loss of GSH was 85% after a 3 hr exposure. At 8 atm O2 a significant drop in GSH concentration was shown to occur in the lens nucleus prior to loss of the tripeptide in the superficial cortex. O2-treated lenses became hazy in appearance, especially at the higher pressures, but did not become densely opaque. Pressures of N2 up to 100 atm had no effect on either lens transparency or on the concentration of GSH. Although oxidized glutathione (GSSG) was detected in the whole lens at pressures of O2 as low as 4 atm, no change in GSH level or evidence for GSSG accumulation was observed in the capsule-epithelium of the lens at pressures as high as 50 atm O2. Ninety percent of the GSSG present in lenses after exposure to 100 atm O2 could be reconverted to GSH by subsequent culture of the lenses under normal conditions. Exposure of lenses to 50 atm O2 produced a three-fold stimulation of hexose monophosphate shunt activity, equal to that which has been reported for treatment of lenses with 0.06 mM H2O2. (ABSTRACT TRUNCATED AT 250 WORDS)
COMPARATIVE ASSESSMENT OF THE QUALITY OF SOME COMMERCIAL BRANDS OF ARTESUNATE AND AMODIAQUINE ANTIMALARIAL COMBINATION DRUGS IN THE NIGERIAN MARKET *

In Nigeria, the increase in demand for artemisinin based combination therapy especially the artesunate and amodiaquine combination has lead to the proliferation of different brands for sale of which some are suspected to be counterfeit or substandard. Therefore, this work was undertaken to assess the quality of some artesunate and amodiaquine combination brands sold in Nigeria using HPLC. Three fixed doses and one co – blistered brands of artesunate were assessed using uniformity of weight, disintegration time, tensile stregnth and friability tests. H.P.L.C. was used to determine the percentage artesunate and amodiaquine content of the tablets. Results showed that crushing strength (N) ranged from 4.49 ± 1.37 to 13.70 ± 4.56 kgf. Friability ranged from 0.001 to 0.800 and disintegration time was from 28.28 ± 4.62 to 92.65 ± 23.37. For weight uniformity test, none deviated by up to 5% which was satisfactory. The retention time for amodiaquine and artesunate were 4.2 min and 6.2 min respectively. The percentage concentration of amodiaquine in batches A, B, C, and D1 were 98, 98, 99 and 98.5% respectively while the percentage artesunate concentration was 97, 98, 98 and 99% for batches A, B, C and D2 respectively. The result showed that the products passed the tests. Having met the pharmacopoeia recommendations, the products were confirmed not to be substandard.
Improving Outcomes of Liver Retransplantation: An Analysis of Trends and the Impact of Hepatitis C Infection

Retransplantation (RT) in Hepatitis C (HCV) patients remains controversial. Aims: To study trends in RT and evaluate the impact of HCV status in the context of a comprehensive recipient and donor risk assessment. The UNOS database between 1994 and October 2005 was utilized to analyze 46 982 LT and RT. Graft and patient survival along with patient and donor characteristics were compared for 2283 RT performed in HCV and non‐HCV patients during 1994–1997, 1998–2001 and 2002–October 2005. Overall HCV prevalence at RT increased from 36% in the initial period to 40.6% after 2002. In our study group, 1‐year patient and graft survival post‐RT improved over the same time intervals from 65.0% to 70.7% and 54.87% to 65.8%, respectively. HCV was only associated with decreased patient and graft survival with a retransplant (LT‐RT) interval (RI) >90 days. Independent predictors of mortality for RT with RI >90 days were patient age, MELD score >25, RI <1 year, warm ischemia time ≥75 min and donor age ≥60 (significant for HCV patients only). Outcomes of RT are improving, but can be optimized by weighing recipient factors, anticipation of operative factors and donor selection.
Global impact of antimicrobial resistance

The advent of the first antimicrobial medication in 1928, penicillin, gave healthcare practitioners a powerful tool in their arsenal with which to combat infectious disease. Since the days of penicillin, medical technology has continued to generate scores of antimicrobial agents, targeting bacteria, fungi, viruses, and protozoa. However, these organisms have concurrently evolved mechanisms of antimicrobial resistance, and the medical community is losing an arms race with infectious organisms that were once simple to treat. Therefore, the onus is now not only on the medical community, but also the agriculture and pharmaceutical industries to address this issue promptly. This review will summarize the causes for concern, causes of increasing resistance rates, global impact, and potential strategies to prevent the end of the antimicrobial era.
Phosphine Resistance in Tribolium castaneum and Rhyzopertha dominica from Stored Wheat in Oklahoma

ABSTRACT Phosphine gas, or hydrogen phosphide (PH3), is the most common insecticide applied to durable stored products worldwide and is routinely used in the United States for treatment of bulk-stored cereal grains and other durable stored products. Research from the late 1980s revealed low frequencies of resistance to various residual grain protectant insecticides and to phosphine in grain insect species collected in Oklahoma. The present work, which used the same previously established discriminating dose bioassays for phosphine toxicity as in the earlier study, evaluated adults of nine different populations of red flour beetle, Tribolium castaneum (Herbst), and five populations of lesser grain borer, Rhyzopertha dominica (F.) collected from different geographic locations in Oklahoma. One additional population for each species was a laboratory susceptible strain. Discriminating dose assays determined eight out of the nine T. castaneum populations, and all five populations of R. dominica, contained phosphine-resistant individuals, and highest resistance frequencies were 94 and 98%, respectively. Dose-response bioassays and logit analyses determined that LC99 values were ≈3 ppm for susceptible and 377 ppm for resistant T. castaneum, and ≈2 ppm for susceptible and 3,430 ppm for resistant R. dominica. The most resistant T. castaneum population was 119-fold more resistant than the susceptible strain and the most resistant R. dominica population was over 1,500-fold more resistant. Results suggest a substantial increase in phosphine resistance in these major stored-wheat pests in the past 21 yr, and these levels of resistance to phosphine approach those reported for other stored-grain pest species in other countries.
Analysis on the Online Reviews Based on Hidden Markov Model

In this study, a new sentiment analysis model of online-shopping reviews based on hidden Markov model has been proposed. Both the influence of the latest two comments and the most popular comment from the Amazon Japan review page are taken into consideration. The supervised training method is used to train this model, and then the model is optimized by using a variation of genetic algorithm. The performance is evaluated through an experiment of sentiment classification of online-shopping reviews of Amazon Japan’s tea category comparing to other methods from previous ones such as Support Vector Machine, Logistic Regression with built-in cross-validation and so on. The result shows that the adapted hidden Markov model has the highest f1 score among the other baseline methods.
What is the Relationship Among Cleaner Production, Pollution Prevention, Waste Minimization and ISO 14000?

In the last 15 years there has been a growing world wide movement among government and industry to change the way industry interacts with the environment. The focus of this movement has been to reduce environmental impacts from industry through changes in industrial behavior and technology. There are a number of terms that are used to describe both the movement and the approaches being used. All of them are based on what is commonly known as the “precautionary Principle,” also known by the old saying, ”an ounce of prevention is worth a pound of cure. ” It is better, and usually much less expensive, to prevent environmental problems from happening than to fix them once they are created. And if we don’t know what effects our actions will have on the environment, we should proceed with caution and try to minimize any potential effects that might occur.
HMD with Pupillary Response Meter and Its Application to Virtual Lathe Operation

An HMD with a pupillary response that works under dynamic environment is developed. It is known that pupillary dilations and constrictions are governed by the autonomic nervous system. The HMD measure the pupil size with an infrared camera by image processing. Visual stimuli provided via video-see-through by the Augmented Reality technique. Virtual Environment of the lathe operation is used to display the accident to the participants without injury.
Accelerated SQLite database using GPUs

This paper introduces the development of a new GPU-based database to accelerate data retrieval. The main goal is to explore new ways of handling complex data types and managing data and workloads in massively parallel databases. This paper presents three novel innovations to create an efficient virtual database engine that executes the majority of database operations directly on the GPU. The GPU database executes a subset of SQLite’s SELECT queries, which are typically the most computationally expensive operations in a transactional database. This database engine extends existing research by exploring methods of table caching on the GPU, handling irregular and complex data types, and executing multiple table joins and managing the resulting workload on the GPU. The GPU database discussed in this paper is implemented on a consumer grade GPU to demonstrate the high-performance computing benefits of relatively inexpensive hardware. Advances are compared both to existing CPU standards and to alternate implementations of the GPU database.
À procura do trabalho perdido ( In search of lost work )

Outra vez te revejo, cidade de minha infância pavorosamente perdida . Cidade triste e alegre, outra vez sonho aqui . Eu? Mas sou eu o mesmo que aqui vivi, e aqui voltei, E aqui tornei a voltar, e a voltar? E aqui de novo tornei a voltar? Ou somos, todos os Eu que estive aqui ou estiveram, Uma série de contas-entes ligadas por um fio-memória, Uma série de sonhos de mim de alguém de fora de mim? [. ] Outra vez te revejo, Mas, ai, a mim não me revejo Partiu-se o espelho mágico em que me revia idêntico, E em cada fragmento fat́ıdico vejo só um bocado de mim — Um bocado de ti e de mim!
The production of grammatical and lexical determiners in Broca’s aphasia

ABSTRACT Determiner production is a testing ground for theories of Broca’s aphasia and agrammatic speech. On one type of theory, determiner production is impaired in so far as determiners are grammatical items. On another type of theory, determiner production is impaired because determiners depend on verbs for case-assignment. These two types of theories are mutually compatible, but in recent years, research on determiner production has focused on the second type. In order to test the first type, an experiment was carried out which contrasted the production of Danish grammatical determiners (indefinite articles) and lexical ones (numerals) in five speakers diagnosed with Broca’s aphasia and four non-brain-damaged controls. The results strongly support the first type of theories: (1) in agrammatic speech, only grammatical determiners were omitted to an extent which differs from omission rates in the speech of the controls; (2) substitutions of grammatical agreement markers were found only in agrammatic speech.
Predictors of Subjective Well-Being Across Cultures

We provide an overview of well-documented factors that predict and explain national and cultural differences in happiness. A brief history of the culture and happiness research is offered, followed by a literature summary on how cultural variations in happiness is related with objective life conditions, lay cultural beliefs of happiness, emotion patterns, characteristics of the self, and excessive concerns of social evaluation in East Asian cultures. We also briefly comment on findings from the culture-person fit research, and introduce recent biological and ecological papers that may point to new research directions for the culture and happiness field.
of the Bioflux Society Detection of Vibrio spp . in shrimp from aquaculture sites in Iran using polymerase chain reaction ( PCR )

Shrimp is one of the most important fishery products of the coastal provinces in the Persian Gulf in Iran. Vibriosis has been an important cause of production loss due to bacterial disease in shrimp farms in south Iran in recent years. The objective of this study was to detect the prevalence of Vibrio spp. in shrimp samples from farms in the southern provinces of Iran by polymerase chain reaction (PCR). A total number of 36 shrimp were caught from south coast of Iran and were studied to identify Vibrio spp. Three Vibrio species including Vibrio parahemolyticus, V. alginolyticus and V. harveyi were identified using biochemical and molecular methods. Two shrimp contained one or more Vibrio spp. as two samples contained V. parahemolyticus, two samples contained V. alginolyticus and two contained V. harveyi. The results of the present study revealed that the shrimp from the studied area is contaminated with Vibrio spp. and molecular detection systems were applied for the investigation of shrimp samples for the presence of the different Vibrio spp. The collected data indicate that the PCR systems can be useful for rapid detection and differentiation of Vibrio spp. in shrimp samples as basis for preventive protection policy to consumers.
Integrated balun design for dual-band WLAN a/b/g applications

This paper presents an integrated balun design optimized for low insertion loss and minimal imbalance. The concept of an integrated dual-band balun is proposed to significantly improve the integration and reliability of WLAN a/b/g transceivers. The design has been implemented in standard 90nm CMOS technology. The measured minimum insertion loss (ILmin) is 1.6 dB in the 2.4 GHz band, and 1.2 dB at 5.6 GHz. The measured phase imbalance is less than 0.4deg, and the amplitude imbalance is below 0.1 dB, in both frequency bands. Attributed to its symmetry, the balun yields more than 40 dB attenuation of undesired mode conversions. The balun core occupies 220 mum x 220 mum, and has the lowest measured insertion loss reported to date for integrated baluns in standard CMOS.
Is Isoprene Emitted by Plants Synthesized via the Novel Isopentenyl Pyrophosphate Pathway?

Abstract The incorporation of deuterium labeled 1-deoxy-ᴅ-xylulose into isoprene, emitted by three higher plants upon illumination, was analysed by headspace GC-MS. A high extent of incorporation into isoprene was found, indicating that isoprene is synthesized in higher plants via the novel isopentenyl pyrophosphate pathway, of which 1-deoxy-ᴅ-xylulose-5-phosphate is an intermediate. A new chemical synthesis of methyl [ 1-2H1]-1-deoxy-α/β-ᴅ-xyluloside from ᴅ-xylulose is presented.
Gas Sensing with Nanoplasmonic Thin Films Composed of Nanoparticles (Au, Ag) Dispersed in a CuO Matrix

Magnetron sputtered nanocomposite thin films composed of monometallic Au and Ag, and bimetallic Au-Ag nanoparticles, dispersed in a CuO matrix, were prepared, characterized, and tested, which aimed to find suitable nano-plasmonic platforms capable of detecting the presence of gas molecules. The Localized Surface Plasmon Resonance phenomenon, LSPR, induced by the morphological changes of the nanoparticles (size, shape, and distribution), and promoted by the thermal annealing of the films, was used to tailor the sensitivity to the gas molecules. Results showed that the monometallic films, Au:CuO and Ag:CuO, present LSPR bands at ~719 and ~393 nm, respectively, while the bimetallic Au-Ag:CuO film has two LSPR bands, which suggests the presence of two noble metal phases. Through transmittance-LSPR measurements, the bimetallic films revealed to have the highest sensitivity to the refractive index changes, as well as high signal-to-noise ratios, respond consistently to the presence of a test gas.
PRELIMINARY EVALUATION OF A NEW SCREENING TEST FOR DEMENTIA (EUROTEST)

Introduction. The changeover to the new currency has meant that the Money test, a screening test for dementia with a number of advantages over those currently available, is now of no use. Aims. Our aim was to perform a preliminary evaluation of the Eurotest, which is a version of the Money test adapted to the new currency system. Subjects and methods. Design: phase I, diagnostic evaluation (convenience sampling; pre-test prevalence 50%). Subjects: > 65 years with no sensory deficit; 30 with mild dementia and 30 without dementia. Method: evaluation of socio-demographic variables and of mini-mental performance (MMSE), Pfeiffer’s test (SPMSQ), the seven-minute test (7MT) and Eurotest. Statistical study: comparison between groups using t test and chi squared, depending on the variables; determination of diagnostically useful parameters and ROC curves, with their respective 95% confidence intervals; linear regression study with a ‘step-by-step’ strategy. Results. The groups did not differ as regards age, sex, level of schooling, degree of literacy, employment and knowledge of money systems. The Eurotest has a sensitivity of 0.93 (0.760.99) and a specificity of 0.87 (0.68-0.96), which is similar to that of the MMSE and the 7MT. The Eurotest (6.77±1.65 min) takes less time than the 7MT (8.87±1.81 min) and is not modified by the subject’s clinical situation. The level of schooling does not affect the results of the Eurotest. Conclusions. The Eurotest is simple, quick, valid, useful and is unaffected by the level of schooling, which are features that make it a valid alternative to the tests currently available. [REV NEUROL 2004; 38: 201-9]