Miracle-dz/UniFAR-FTUs huggingface dataset:
The impact of lymphovascular invasion in patients with prostate cancer following radical prostatectomy and its association with their clinicopathological features

Objective: Numerous studies have shown that lymphovascular invasion (LVI) is linked to biochemical recurrence (BCR) in prostate cancer (PCa) patients following radical prostatectomy (RP). However, the actual clinicopathological impacts of LVI remain unclear. Thus, we performed a meta-analysis to evaluate the pathologic and prognostic impacts of LVI in PCa patients. Methods: Following the guidance of the PRISMA statement, relevant studies were collected systematically from the PubMed, EMBASE, and Web of Science databases to identify relevant studies published before June 2018. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated to investigate the association of LVI with BCR and clinicopathological features. Results: A total of 20 studies including 25,570 patients (106–6678 per study) with PCa were incorporated into this meta-analysis. Overall pooled analysis suggested that LVI was associated with a higher BCR risk both in univariate (pooled HR=1.50, 95% CI: 1.34–1.68, P <.001) and multivariate analyses (pooled HR=1.25, 95% CI: 1.17–1.34, P <.001). In addition, LVI was closely correlated with extraprostatic extension (yes vs no: OR = 4.23, 95% CI: 1.86–9.61, P <.001), pathological GS (≥7 vs <7: OR = 5.46, 95% CI: 2.25–13.27, P <.001), lymph node metastases (yes vs no: OR = 18.56, 95% CI: 7.82–44.06, P <.001), higher pathological stage (≥ T3 vs < T2: OR = 6.75, 95% CI: 5.46–8.36, P <.001), positive surgical margin (positive vs negative: OR = 2.42, 95% CI: 1.57–3.72, P <.001) and seminal vesicle invasion (yes vs no: OR = 5.72, 95% CI: 2.45–13.36, P <.001). Conclusions: This study suggests that LVI in histopathology is associated with a higher risk of BCR and advanced clinicopathological features in PCa patients and could serve as a poor prognostic factor in patients who underwent RP.
Review of light parameters and photobiomodulation efficacy: dive into complexity

Abstract. Photobiomodulation (PBM) therapy, previously known as low-level laser therapy, was discovered more than 50 years ago, yet there is still no agreement on the parameters and protocols for its clinical application. Some groups have recommended the use of a power density less than 100 mW/cm2 and an energy density of 4 to 10 J/cm2 at the level of the target tissue. Others recommend as much as 50 J/cm2 at the tissue surface. The wide range of parameters that can be applied (wavelength, energy, fluence, power, irradiance, pulse mode, treatment duration, and repetition) in some cases has led to contradictory results. In our review, we attempt to evaluate the range of effective and ineffective parameters in PBM. Studies in vitro with cultured cells or in vivo with different tissues were divided into those with higher numbers of mitochondria (muscle, brain, heart, nerve) or lower numbers of mitochondria (skin, tendon, cartilage). Graphs were plotted of energy density against power density. Although the results showed a high degree of variability, cells/tissues with high numbers of mitochondria tended to respond to lower doses of light than those with lower number of mitochondria. Ineffective studies in cells with high mitochondrial activity appeared to be more often due to over-dosing than to under-dosing.
Antinephrolithiatic Potential of Macrotyloma uniflorum Aqueous Extract in Rats

Urolithiasis is a major health problem with its high morbidity, high cost of management and potential for end-stage renal disease. The aim of our study is to cure and prevent the recurrent stone formation. Herbal drugs claim many promising remedies in urolithiasis. An attempt is made in this direction in the current work by using Macrotyloma uniflorum. The experimental model selected for the present study is subcutaneous administration of gentamicin (40mg/kg/day) for 8 days and dietary supplementation with 5% ammonium oxalate starting at day 5 of the treatment regimen to induce calcium oxalate urolithiasis. On administration of aqueous extract of Macrotyloma uniflorum in preventive and curative groups, moderate to few crystals are observed along the mild appearance of edema and dilation in tubules and crystals are present focally indicating the ability of aqueous extract of Macrotyloma uniflorum to dissolve the preformed stones. The parameters monitored in the present study are Kidney weight, calcium and oxalate deposition in kidney and the histological studies support the calcium and oxalate deposition data in kidney. Thus aqueous extract of Macrotyloma uniflorum showed significant antinephrolithiatic activity.
Saint Chrysostom: homilies on the acts of the apostles and the Epistle to the Romans

ly of the resurrection as to give rise to such a misapprehension. Paul doubtless spoke of Jesus’ own resurrection and of its relation to that of believers (vid. 1 Cor. xv.), although in the text the absence of αὐτοῦ permits us to find only the idea of the general resurrection expressed. —G.B.S. Homily XXXVIII on Acts xvii. 16, 17. 433 Homily XXXVIII on Acts xvii. 16, 17.
Artificial intelligence and upper gastrointestinal endoscopy: Current status and future perspective

With recent breakthroughs in artificial intelligence, computer‐aided diagnosis (CAD) for upper gastrointestinal endoscopy is gaining increasing attention. Main research focuses in this field include automated identification of dysplasia in Barrett's esophagus and detection of early gastric cancers. By helping endoscopists avoid missing and mischaracterizing neoplastic change in both the esophagus and the stomach, these technologies potentially contribute to solving current limitations of gastroscopy. Currently, optical diagnosis of early‐stage dysplasia related to Barrett's esophagus can be precisely achieved only by endoscopists proficient in advanced endoscopic imaging, and the false‐negative rate for detecting gastric cancer is approximately 10%. Ideally, these novel technologies should work during real‐time gastroscopy to provide on‐site decision support for endoscopists regardless of their skill; however, previous studies of these topics remain ex vivo and experimental in design. Therefore, the feasibility, effectiveness, and safety of CAD for upper gastrointestinal endoscopy in clinical practice remain unknown, although a considerable number of pilot studies have been conducted by both engineers and medical doctors with excellent results. This review summarizes current publications relating to CAD for upper gastrointestinal endoscopy from the perspective of endoscopists and aims to indicate what is required for future research and implementation in clinical practice.
Characteristics and Outcome of Thyroid Cancer Patients with Indeterminate Cytology

The objective of this retrospective study was to evaluate the clinical, laboratory, ultrasonographic, and cytological features as well as the surgical outcome of thyroid nodules with initial cytology of indeterminate. The subjects were a total of 1,049 patients with indeterminate cytology, who underwent thyroidectomy between 2005 and 2011 in Ito hospital. All of the patients had undergone an ultrasound examination and fine needle aspiration cytology. The cytological classification used in this study was based on the cytological reporting system recommended by the Japanese guidelines for the management of thyroid nodules published in 2013. Malignancy was diagnosed histologically in 472 patients (45.0%), and the postoperative histological diagnoses in the majority of these cases were classical papillary carcinoma (44.1%) or follicular carcinoma (46.2%). The prevalence of indeterminate cytology was rather lower than that in previous reports, and the follicular variant papillary carcinoma was not a common histological type. Although the follow-up period was short, the outcome of the patients with papillary thyroid carcinoma or follicular thyroid carcinoma was similar to that of those in our previous reports.
Portafolio de consumo: problema de Merton

En este documento exponemos la estructura de base de un problema clasico de control optimal ilustrado a traves de un ejemplo de matematicas financieras. La modelacion es realizada mediante la utilizacion de procesos estocasticos en tiempo continuo y la herramienta utilizada es el calculo estocastico desarrollado por Ito en los anos 60 del siglo pasado. El objetivo de este articulo es mostrar la aplicacion de la teoria de Ito en la eleccion de la mejor inversion para optimizar el consumo de un agente.
CRISE DU CADRE (Art et langage)

Questionner la crise du cadre oblige a une definition rigoureuse de la notion de cadre. Cette crise prend la forme d'un doute : peut-on analyser l'art en un temps ou sa definition est elle-meme problematique ? Exemplaire, la figure de Malevitch porte en elle-meme les signes de contradictions de son epoque et celles-ci sont a l'origine de plusieurs phases de crise qui se manifestent encore de nos jours. Malevitch, un des premiers, a suppose des cadres conceptuels pour comprendre un " langage de l'art " (" l'element additionnel ", 1927). Un cadre materiel se transforme ainsi en un cadre conceptuel, le cadre de reference (" frame of reference ") chez Nelson Goodman. Sa theorie (" Langages de l'art ", 1968) est ici consideree comme celle du cadre modelant. La crise du cadre dans l'art ramene au moteur de la creation. Toutes les crises constatees - celles du discours, de l'œuvre, du lieu, de l'artiste, du regard - contribuent a l'ouverture de nouvelles visions et donc, en un sens plus large, a la creation.
Seamless service continuity in cloud based lte systems

Cloud computing model offers better network resource utilization by pooling shared computing resources that can be rapidly provisioned and released. The increasing use of mobile devices (e.g. smart phones, tablets, etc.) has increased the complexity in provisioning cellular network resources. Applying cloud computing model in LTE systems could be a good solution to increase LTE’s performance by building a shared distributed LTE mobile network that can optimize the utilization of resources, minimize communication delays, and avoid bottlenecks. One of the most important concepts used in mobile networks is service continuity. Mobile users moving from one sub-network to another sub-network should be able to seamlessly continue retrieving content and use services (e.g. video streaming, gamming, VoIP, etc.) that they want. In cloud based LTE systems, services are hosted on Virtual Machines (VMs) that can move and migrate across multiple networks to locations that are the best to deliver services to mobile users. The migration of VMs and/or service/functionality instances running on such VMs should happen without losing service continuity. In this thesis, Content Centric Networking (CCN) is evaluated and verified whether it is possible to be implemented in cloud based LTE systems as a solution for service continuity. Several integration options of CCN in LTE systems and the proposed solutions to support VM and/or content migration are described in detail. Two sets of experiments that focus on “Content Migration Support” and “VM and Content Migration Support” are implemented and performed using ns-3 LENA simulation environment together with ndnSIM. The simulation results demonstrate that the proposed solution can support seamless service continuity when content migration occurs. However, in order to support service continuity when VM migration occurs, the implementation of solutions such as mobility prediction systems are needed to predict the movement of users and determine when the VM migration should be triggered in advance.
Recidiva postrasplante de hepatopatías no virales

Objetivo: El objetivo del presente trabajo fue analizar la frecuencia y presentacion de recidiva de hepatopatias postrasplante no virales. Metodos y Resultados: Los pacientes con hepatopatias no virales que recibieron un trasplante hepatico fueron 39 y de estos, seis presentaron recidiva de la enfermedad (15.3%): uno con recaida del alcoholismo, tres con enfermedad autoinmune (dos trasplantados por cirrosis biliar primaria recurrieron con hepatitis autoinmune y uno con diagnostico original de cirrosis hepatica criptogenica presento recurrencia de hepatitis autoinmune), uno con diagnostico de esteatohepatitis no alcoholica tuvo recurrencia con la misma enfermedad; por ultimo, un paciente se trasplanto por cirrosis hepatica secundaria a metotrexate y postrasplante manifesto cirrosis biliar secundaria a estenosis del coledoco en el sitio de la anastomosis. Conclusiones: Todos los pacientes aqui analizados presentaron recidiva en el largo plazo (despues de 11 meses postrasplante). La recidiva del alcoholismo se identifico en 8.3%, de las hepatopatias autoinmunes en 30%, y de la esteatohepatitis no alcoholica en 20% de los casos. Las tres pacientes con recidiva de hepatopatia autoinmune presentaron en el postras-plante una enfermedad diferente a la que dio origen al trasplante.
Historical Review of "Kampung" Baluwerti in Keraton Palace as "Evidence" of Java Villages' Development in Surakarta

“Kampung” Baluwerti established by Paku Buwono II became an area outside Keraton Palace. This “kampung” is very specific because it is not only a town village, but also a royal “kampung”. Those names of sub-“kampung” were provided by the king according to toponymy. There are some preceding writers researching on Keraton (Javanese palace), but no one yet researching on that “kampung”. Seen from its existence, it is very specific and attractive to research. Had the form alteration of “kampung” occurred spatially at the time when the king ruled (past time) and at the time of post-power alteration (from kingdom to city government/present time)? How is its link with toponymy from the form, sign, and symbol sides? This research will use method of the grounded research, since it includes aspects of history, culture, and architecture. The research is done by revealing via: (1) appearance visually; (2) element observation becoming the symbol or myth; (3) observation of human or mobile products that is non-material through symbol expression or myth with the meaning hidden behind that; and (4) research of element permanent and change toward the element meant as symbol or myth. Research is coupled with theory of power that has relations to king, symbol, and myth.
Realtime tracking and identification of multiple objects in a cluttered environment

The authors have developed a distributed multi-module system for realtime tracking of objects, and online training of neural network classifiers. The aim of the project was to build a system which is able to locate objects and to follow them and learn to recognise them with minimal supervision. The problem domain chosen was the tracking and recognition of three species of tropical fish swimming in an aquarium. >
LOG Analiz: Erişim Kayıt Dosyaları Analiz Yazılımı ve GOP Üniversitesi Uygulaması

Internet kullanicilarinin web sitesi ziyareti suresince geride biraktigi izler sunucu uzerindeki erisim kayit dosyalarinda tutulmaktadir. Bu verilerin analiz edilerek bilgiye donusturulmesi web madenciligi ile yapilmaktadir. Bu calisma ile web sunucu erisim kayitlarinin web kullanim madenciligi ile analizi icin “Log Analiz” isminde bir yazilim gelistirilmistir. Hazirlanan yazilim web sitesine ait cesitli istatistiki bilgileri cikarmakta ve apriori algoritmasi ile birliktelik kuralLarini bulmaktadir. Log Analiz ile Gaziosmanpasa Universitesi kurumsal web sitesine ait 15 gunluk sunucu erisim kayitlari incelenmis ve analiz sonuclari verilmistir. Boylece, web sitesine ait erisim kayitlari kolayca analiz edilebilecek ve atil durumdaki veriler bilgiye donusturulebilecektir.
The Sense of Ensemble: a Machine Learning Approach to Expressive Performance Modelling in String Quartets

Computational approaches for modelling expressive music performance have produced systems that emulate music expression, but few steps have been taken in the domain of ensemble performance. In this paper, we propose a novel method for building computational models of ensemble expressive performance and show how this method can be applied for deriving new insights about collaboration among musicians. In order to address the problem of inter-dependence among musicians we propose the introduction of inter-voice contextual attributes. We evaluate the method on data extracted from multi-modal recordings of string quartet performances in two different conditions: solo and ensemble. We used machine-learning algorithms to produce computational models for predicting intensity, timing deviations, vibrato extent, and bowing speed of each note. As a result, the introduced inter-voice contextual attributes generally improved the prediction of the expressive parameters. Furthermore, results on attribute selection show that the models trained on ensemble recordings took more advantage of inter-voice contextual attributes than those trained on solo recordings.
Molecular Neuropharmacology: A Foundation for Clinical Neuroscience

An engagingly written, vibrantly illustrated reference that expertly links neurobiology, clinical psychiatry, and neurology Molecular Neuropharmacology first reviews the fundamental biochemistry of the functioning nervous system and then describes in clear, concise and consistent terms how nerve cells communicate with one another through numerous types of neurotransmitters involving amino acids, monoamines, neuropeptides, and neurotrophic factors, among several others. The neuropharmacology and neural circuits that underlie complex behaviors as well as major neural disorders are then discussed as are the drugs used to treat those conditions. In this final section, the authors use the concepts presented in the first two sections to explain how irregularities in the biochemistry of neuronal interactions can lead to a wide array of clinical manifestations. Key points begin every chapter for a brief overview. Each chapter is packed with figures, tables and text boxes (presented on every page and accessible with clear color coding). More than 300 detailed diagrams provide specific information on receptor and drug families, biosynthetic and metabolic pathways, and interactions between the nervous system and the rest of the body. Simple and elegant, these illustrations are rich enough in content to serve as brief overviews of each chapter when viewed alone. Features NEW chapter on neuroinflammation All chemical structure illustrations have been redrawn and improved Fully updated to reflect the latest breakthroughs and new drugs The best written and most easily understood work on the subject
Geschiedenis van de afasiologie: Franz Joseph Gall (1758-1828)

Eind 18e eeuw introduceerde Franz Joseph Gall (1758-1828) het concept van discrete corticale lokalisatie van mentale functies in de wetenschappelijke wereld. Op basis van het bevoelen van de schedel (‘cranioscopie’) onderscheidde en lokaliseerde hij 27 faculteiten waaronder het taalvermogen, dat hij als eerste in de frontale cortex plaatste. Broca’s ontdekking van het spraakcentrum in 1861 was de uitkomst van het lokalisatiedebat dat in reactie op de ideeen van Gall ontstond. In dit artikel wordt aandacht besteed aan Gall’s plaats in de geschiedenis van de wetenschap, zijn leven, leerstelsel en de ‘frenologie’, een latere aanpassing van het leerstelsel die vooral gericht was op sociale hervorming. Gall werd tijdens zijn leven geprezen als neuroanatoom vanwege een aantal belangrijke neuroanatomische ontdekkingen, maar de reacties op zijn leerstelsel waren wisselend. Halverwege de 19e eeuw was zijn ‘organologie’ verworpen als serieuze wetenschappelijke doctrine, waarna het nog tot het begin van de 20e eeuw voortleefde als een vorm van karakteranalyse uitgevoerd door ‘praktische frenologen’, die tegen betaling schedels lazen. Het leerstelsel dat begin 19e eeuw plausibel werd geacht komt ons vandaag de dag absurd voor, maar wellicht wordt over honderd jaar hetzelfde oordeel geveld over onze huidige ideeen en methoden van onderzoek inzake de relatie tussen taal en hersenen.
Stability analysis of neural networks based adaptive controllers for robot manipulators

This paper presents an approach to the stability analysis of neural networks based adaptive controllers for motion control of robot manipulators. New adaptive feedback and feedforward control structures using neural networks are proposed. The controllers are adaptive to robot dynamics and payload uncertainties. Practical asymptotic stability conditions for the proposed controllers are given considering the neural networks learning errors. A robust adaptive approach which leads to global asymptotic stability is also presented. The analysis includes the evaluation of the control error as a function of the neural networks learning errors.
Diaschisis, Degeneration, and Adaptive Plasticity After Focal Ischemic Stroke

Focal stroke refers to sudden brain dysfunction due to an interruption of blood supply to a particular region of the brain. An ischemic stroke (~80% of focal strokes) occurs due to a blockage of a blood vessel, typically by a blood clot, whereas a haemorrhagic stroke results from rupture of a cerebral blood vessel and the resulting accumulation of blood in the brain parenchyma. Symptoms of stroke will vary depending on the size and location of the tissue damaged by the reduced blood flow (the infarct), but common symptoms include sudden weakness of the limbs or face, trouble speaking or understanding speech, impaired vision, headache and dizziness. According to the World Health Organization (WHO), more than 15 million people suffer a stroke each year, of which five million people will die. Stroke is a leading cause of chronic adult disability worldwide, and the majority of those who survive their stroke (more than five million people per year) are left with permanent sensorimotor disabilities, which may include loss of strength, sensation, coordination or balance (with the nature and severity of disability depending on the location and size of the lesion). Despite the significant societal and personal cost of stroke, treatment options remain limited. Currently, only recombinant tissue-type plasminogen activator (rtPA), a serine proteinase, has proved effective in treating ischemic stroke in clinical trials (NINDS, 1995). Thrombolysis after rtPA administration occurs as a result of plasminogen being converted to plasmin by rtPA. The plasmin then participates in the degradation of fibrin to restore blood flow to territories downstream of the occlusion. Unfortunately, few patients are treated with rtPA, in part due to it short therapeutic window of 4.5 hours (relative to delays in symptom recognition, transport, and triaging) after ischemic onset (Lansberg et al., 2009; Kaur et al., 2004; Clark et al., 1999; Del Zoppo et al., 2009). Moreover, rtPA is ineffective for many patients treated within its therapeutic window, particularly with respect to middle cerebral artery occlusion (MCAo), the most common cause of focal ischemic stroke (Kaur et al., 2004; Seitz et al., 2011). Given the limited treatment options for stroke, an improved understanding of its pathophysiology and the brains endogenous mechanisms for neuroprotection, brain repair and neuroanatomical rewiring is important to developing new strategies and improving stroke care. While death and disability due to stroke can be predicted based on the size and location of the infarct, damage due to stroke extends beyond the ischemic territories. Moreover, while treatment options remain limited, partial recovery after stroke occurs due to adaptive changes (plasticity) in brain structure and function that allow uninjured brain regions to