Miracle-dz/UniFAR-FTUs huggingface dataset:
Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite

Immunity to intestinal helminths is known to require both innate and adaptive components of the immune system activated along the Type 2 IL-4R/STAT6-dependent pathway. We have found that macrophage migration inhibitory factor (MIF) is essential for the development of effective immunity to the intestinal helminth Heligmosomoides polygyrus, even following vaccination which induces sterile immunity in wild-type mice. A chemical inhibitor of MIF, 4-IPP, was similarly found to compromise anti-parasite immunity. Cellular analyses found that the adaptive arm of the immune response, including IgG1 antibody responses and Th2-derived cytokines, was intact and that Foxp3+ T regulatory cell responses were unaltered in the absence of MIF. However, MIF was found to be an essential cytokine for innate cells, with ablated eosinophilia and ILC2 responses, and delayed recruitment and activation of macrophages to the M2 phenotype (expressing Arginase 1, Chil3, and RELM-α) upon infection of MIF-deficient mice; a macrophage deficit was also seen in wild-type BALB/c mice exposed to 4-IPP. Gene expression analysis of intestinal and lymph node tissues from MIF-deficient and -sufficient infected mice indicated significantly reduced levels of Arl2bp, encoding a factor involved in nuclear localization of STAT3. We further found that STAT3-deficient macrophages expressed less Arginase-1, and that mice lacking STAT3 in the myeloid compartment (LysMCrexSTAT3fl/fl) were unable to reject a secondary infection with H. polygyrus. We thus conclude that in the context of a Type 2 infection, MIF plays a critical role in polarizing macrophages into the protective alternatively-activated phenotype, and that STAT3 signaling may make a previously unrecognized contribution to immunity to helminths.
Prevalence of multi-drug-resistant tuberculosis among human immunodeficiency virus and nonhuman immunodeficiency virus-positive pulmonary tuberculosis patients of two referral hospitals in Southeast Nigeria

Introduction: Multidrug-resistant tuberculosis (MDR-TB) is a type of TB that is resistant to the two most effective first-line drugs: rifampicin and isoniazid and it remains a major public health threat, particularly in developing countries. Objectives: To assess the MDR-TB prevalence among human immunodeficiency virus (HIV) and nonHIV positive pulmonary TB patients of two referral hospitals in southeast Nigeria. Materials and Methods: Sputum specimens of individuals presenting with a cough of >2 weeks duration were screened by Ziehl–Neelsen technique for the presence of acid-fast bacilli (AFB). Results: A total of 103 subjects with AFB-positive sputum samples were recruited from the two referral hospitals and HIV-1/2 antibodies were screened using serial algorithm method. The positive sputum samples were subjected to Xpert MTB/RIF assay (GeneXpert®, Cepheid, USA) and cultured on the Lowenstein–Jensen medium for 42 days at 37°C. Drug susceptibility testing was done on the isolates using the nitrate reduction assay. Eighty-three (80.6%) of the isolates were obtained from culture after suspected colonies were subjected to morphological, biochemical, and immunological tests and of the 83 (80.6%) samples analyzed using Xpert MTB/RIF assay 45 (67.2%) were rifampicin-resistant. The prevalence of culture-positive TB was higher in the HIV-negative sub-population (82.02%) when compared with the HIV-positive participants (71.40%). The rate of MDR-TB was high among HIV-positive patients though not statistically significant. HIV positive patients showed prevalence of (66.70%), whereas HIV-negative patients had (42.60%). Conclusions: The World Health Organization estimated that 26% of patients with TB infection in Nigeria are HIV-positive and the alarming evidence of MDR-TB prevalence in this study calls for close monitoring of the prevalence of drug resistance, especially in HIV-infected population.
Gut microbial metabolites in depression: understanding the biochemical mechanisms

Gastrointestinal and central function are intrinsically connected by the gut microbiota, an ecosystem that has co-evolved with the host to expand its biotransformational capabilities and interact with host physiological processes by means of its metabolic products. Abnormalities in this microbiota-gut-brain axis have emerged as a key component in the pathophysiology of depression, leading to more research attempting to understand the neuroactive potential of the products of gut microbial metabolism. This review explores the potential for the gut microbiota to contribute to depression and focuses on the role that microbially-derived molecules – neurotransmitters, short-chain fatty acids, indoles, bile acids, choline metabolites, lactate and vitamins – play in the context of emotional behavior. The future of gut-brain axis research lies is moving away from association, towards the mechanisms underlying the relationship between the gut bacteria and depressive behavior. We propose that direct and indirect mechanisms exist through which gut microbial metabolites affect depressive behavior: these include (i) direct stimulation of central receptors, (ii) peripheral stimulation of neural, endocrine, and immune mediators, and (iii) epigenetic regulation of histone acetylation and DNA methylation. Elucidating these mechanisms is essential to expand our understanding of the etiology of depression, and to develop new strategies to harness the beneficial psychotropic effects of these molecules. Overall, the review highlights the potential for dietary interventions to represent such novel therapeutic strategies for major depressive disorder.
Audiological assessment modalities in children with multiple handicaps and parents′ perception

Noorain Alam1, Shamim Ansari2, Deepanshu Gurnani, Vikas Sinha, Pawan K. Sharma, Sachin Jindal Department of ENT and Head and Neck Surgery, M P Shah Government Medical College, Jamnagar, Gujarat, 1Department of Audiology, C U Shah Institute of Audiology and Speech Therapy, Surendranagar, 2Department of Audiology, Ali Yavar Jung National Institute For The Hearing Handicapped, Mumbai, Maharashtra, India
Changes in reaching skill in patients with cervical spondylosis after cervical decompression surgery

[Purpose] The aim of this study was to evaluate the changes in reaching function during a reaching task in cervical spondylosis (CS) patients before and after surgery. [Participants and Methods] Nine patients participated in the study. Wrist acceleration peaks were monitored pre- and postoperatively using a tri-axial accelerometer, and the Japanese Orthopedic Association (JOA) score was recorded preoperatively. Additional upper extremity function tests were performed pre- and postoperatively. Multiple stepwise regression analysis was used to investigate the contribution of wrist acceleration peak to the severity of clinical symptoms. Moreover, we compared the acceleration peaks produced during the reaching task before and after surgery. [Results] Multiple regression analysis showed that wrist acceleration peak, grip strength and pinch strength were associated with the upper extremity function of the JOA score, explaining 61.0% of the variance. There was a significant improvement in x-axis acceleration peak after surgery. [Conclusion] Our results suggested that quantitative assessments of reaching function are useful to objectively evaluate the changes in reaching function in patients undergoing cervical decompression surgery.
Borophene-graphene heterostructures

Borophene and graphene form 2D lateral and vertical heterostructures with sharp and rotationally commensurate interfaces. Integration of dissimilar two-dimensional (2D) materials is essential for nanoelectronic applications. Compared to vertical stacking, covalent lateral stitching requires bottom-up synthesis, resulting in rare realizations of 2D lateral heterostructures. Because of its polymorphism and diverse bonding geometries, borophene is a promising candidate for 2D heterostructures, although suitable synthesis conditions have not yet been demonstrated. Here, we report lateral and vertical integration of borophene with graphene. Topographic and spatially resolved spectroscopic measurements reveal nearly atomically sharp lateral interfaces despite imperfect crystallographic lattice and symmetry matching. In addition, boron intercalation under graphene results in rotationally commensurate vertical heterostructures. The rich bonding configurations of boron suggest that borophene can be integrated into a diverse range of 2D heterostructures.
Superior safety of direct oral anticoagulants compared to Warfarin in patients with atrial fibrillation and underlying cancer: a national veterans affairs database study

Background Studies evaluating safety of warfarin and direct oral anticoagulants (DOACs) for prevention of stroke in patients with atrial fibrillation (AF) are lacking. Methods & Results All patients (n = 196,521) receiving care at veteran's affairs with active cancer and AF from 2010–2015 were included. One-year mortality was significantly higher in unadjusted analysis with warfarin (44.9%) compared to dabigatran (25%, P < 0.001), rivaroxaban (24.4%, P < 0.001) and apixaban (30%, P < 0.001) and after adjusting for age, sex and type of cancer mortality (OR = 2.66, 95% CI: 2.52–2.82, P < 0.001). Risk of ischemic stroke (13.5% vs. 11.1%, 12.0%, 14.0%) was similar, however risk of hemorrhagic stroke was significantly higher among patients receiving warfarin (1.2%) compared to patients receiving dabigatran (0.5%), rivaroxaban (0.7%) and apixaban (0.8%) respectively, P = 0.04. Conclusions We demonstrated the superior safety profile of DOACs compared to warfarin among patients with underlying cancer and AF. Warfarin was associated with higher mortality, similar ischemic stroke risk but higher risk of hemorrhagic stroke.
Optimum production plan for maize-based crop farmers in Niger State, Nigeria

The study tried to address optimum production plan for maize-based crop farmers in Niger State, Nigeria. Primary data were collection with the aid of a structured questionnaire. Simple random sampling technique was used in selecting a total of 133 farm households engaged in maize-based crop production. The results showed that maize-based arable crop production in the study area is predominantly male activity, with a mean age of 37 years. The average household size of the respondents was 5 persons. Majority (86.46%) of the farmers had one form of formal education ranging from tertiary, primary, secondary and adult education. Also, 81.95% of the farmers earned less than ₦100,000 per annum from off-farm activities. An average farmer had 20 years of farming experience and cultivated 1.88 ha of land. Linear programming solution prescribed maize/soybeans on 1.1988 ha and maize/cowpea on 0.0468 ha respectively in the optimum farm plans for the farmers. It also indicated gross margin could be increased from ₦120,122.73 ha −1 in the existing crop production plan to ₦211,555.70 ha −1 in the prescribed optimum crop production plan. It was concluded that production inputs were not optimally utilized and that crop mixtures were in a better competitive position than sole crop to increase the farmers’ income in maize-based crop production systems in Niger State. It was recommended that farmers should produce crop mixtures maize/soybeans and maize/cowpea based on their hectarage allocation as prescribed in the optimum farm plans and that farm advisory services should give attention to optimum cropping patterns towards promoting increased agricultural productivity among farmers. Keywords: linear programming, sole crop, crop mixtures, income
A Qualitative Study of Mentally Ill Women Who Commit Filicide in Gauteng, South Africa

Introduction: Filicide is the deliberate act of a parent killing his/her own child and a major contributor to child homicide rates. In order to prevent future homicides of this nature and aid in the rehabilitation of those mentally ill women who perpetrate these crimes, it is important to gain a better understanding of the dynamics that may result in filicide and the association of the mental illness with filicide. It is also important to explore how the rehabilitation processes are experienced and the impact they have had. The purpose of this study was to examine the perceptions of women regarding their offenses and their perceptions about their treatment and rehabilitation in a South African context. Method: This was a qualitative study which followed a naturalistic paradigm. The data from the semistructured interviews conducted were analyzed using thematic analysis. The use of subjective experiences and descriptions by the participants aimed to give a representation of the participants’ lived experience. This allowed the authors to explore the emerging themes, subthemes, and concepts and organize the most replicated information into a hierarchical assessment. The semistructured interviews were conducted with seven filicidal women with mental illness between July 2016 and April 2017 at Sterkfontein Hospital, Gauteng, South Africa. Results: Most filicidal mothers were psychotic at the time of the offense and perceived trauma and remorse for their offenses. Support from the community and empathy and unconditional positive regard from the staff, notably psychologists, and occupational therapists were overwhelmingly present. Conclusion: Filicide is tragic and largely understudied, particularly from the perpetrator’s perspective. When perpetrators are mentally ill, rehabilitation within a nonjudgmental and empathetic environment is necessary.
Improving the Detection of Individuals at Clinical Risk for Psychosis in the Community, Primary and Secondary Care: An Integrated Evidence-Based Approach

Background: The first rate-limiting step for improving outcomes of psychosis through preventive interventions in people at clinical high risk for psychosis (CHR-P) is the ability to accurately detect individuals who are at risk for the development of this disorder. Currently, this detection power is sub-optimal. Methods: This is a conceptual and nonsystematic review of the literature, focusing on the work conducted by leading research teams in the field. The results will be structured in the following sections: understanding the CHR-P assessment, validity of the CHR-P as a universal risk state for psychosis, and improving the detection of at-risk individuals in secondary mental health care, in primary care, and in the community. Results: CHR-P instruments can provide adequate prognostic accuracy for the prediction of psychosis provided that they are employed in samples who have undergone risk enrichment during recruitment. This substantially limits their detection power in real-world settings. Furthermore, there is initial evidence that not all cases of psychosis onset are preceded by a CHR-P stage. A transdiagnostic individualized risk calculator could be used to automatically screen secondary mental health care medical notes to detect those at risk of psychosis and refer them to standard CHR-P assessment. Similar risk estimation tools for use in primary care are under development and promise to boost the detection of patients at risk in this setting. To improve the detection of young people who may be at risk of psychosis in the community, it is necessary to adopt digital and/or sequential screening approaches. These solutions are based on recent scientific evidence and have potential for implementation internationally. Conclusions: The best strategy to improve the detection of patients at risk for psychosis is to implement a clinical research program that integrates different but complementary detection approaches across community, primary, and secondary care. These solutions are based on recent scientific advancements in the development of risk estimation tools and e-health approaches and have the potential to be applied across different clinical settings.
Adult Attachment Style, Emotion Regulation, and Social Networking Sites Addiction

While there is substantial evidence that emotion regulation plays a role in the maintenance of substance and behavior addiction, its role in addiction to social networking sites (SNS) remains unclear. Drawing on attachment theory, we explore whether emotion regulation mediates the relationship between insecure attachment and SNS addiction among 463 college students. The participants completed the short version of the Experience in Close Relationships Scale, Difficulties in Emotion Regulation Scale, and Chinese Social Media Addiction Scale. The results indicated that attachment anxiety positively predicted SNS addiction and that emotion regulation mediated this link. These findings suggest that individuals’ affective regulation capability should be a target of future interventions and treatments.
A Sensitive, Specific and Simple Loop Mediated Isothermal Amplification Method for Rapid Detection of Campylobacter spp. in Broiler Production

Campylobacteriosis is one of the most common foodborne diseases worldwide. Two Campylobacter species – C. jejuni and C. coli in poultry and poultry products are considered to be the main source of human campylobacteriosis. Therefore, studying Campylobacter status in poultry flocks is needed to prevent transmission of disease and reduce human risk, health cost, and economic losses. In this study, we adapted and used a Loop-Mediated Isothermal Amplification (LAMP) assay for specific, sensitive, simple and cost-effective rapid detection of C. jejuni and C. coli in the poultry production chain. Amplified LAMP products were detected using a small, low-cost portable commercial blue LED transilluminator and a direct visual detection strategy was demonstrated. By using optimized conditions for amplification a limit of detection (LOD) of 50 CFU/ml was achieved for testing of C. jejuni and C. coli in spiked chicken feces without enrichment. The method took 60–70 min from receiving the samples to the final results (including 30 min for amplification). The optimized LAMP showed a relative accuracy of 98.4%, a specificity of 97.9%, and a sensitivity of 100% in comparison to real-time PCR method. Cohen’s kappa index also showed an excellent agreement (0.94) between the two methods. The results showed that the method is specific, sensitive and is suitable to develop for rapid detection of Campylobacter spp. at poultry production.
Investigating the Impact of Image Content on the Energy Efficiency of Hardware-accelerated Digital Spatial Filters

Battery-operated low-power portable computing devices are becoming an inseparable part of human daily life. One of the major goals is to achieve the longest battery life in such a device. Additionally, the need for performance in processing multimedia content is ever increasing. Processing image and video content consume more power than other applications. A widely used approach to improving energy efficiency is to implement the computationally intensive functions as digital hardware accelerators. Spatial filtering is one of the most commonly used methods of digital image processing. As per the Fourier theory, an image can be considered as a two-dimensional signal that is composed of spatially extended two-dimensional sinusoidal patterns called gratings. Spatial frequency theory states that sinusoidal gratings can be characterised by its spatial frequency, phase, amplitude, and orientation. This article presents results from our investigation into assessing the impact of these characteristics of a digital image on the energy efficiency of hardware-accelerated spatial filters employed to process the same image. Two greyscale images each of size 128 × 128 pixels comprising two-dimensional sinusoidal gratings at maximum spatial frequency of 64 cycles per image orientated at 0° and 90°, respectively, were processed in a hardware implemented Gaussian smoothing filter. The energy efficiency of the filter was compared with the baseline energy efficiency of processing a featureless plain black image. The results show that energy efficiency of the filter drops to 12.5% when the gratings are orientated at 0° whilst rises to 72.38% at 90°.
Factors associated with antidepressant responses to repetitive transcranial magnetic stimulation in antidepressant-resistant depression

Background A significant proportion of patients with major depressive disorder (MDD) failed to respond to antidepressant medications. Repetitive transcranial magnetic stimulation (rTMS) is an effective option for treating such treatment-resistant patients with MDD (TRD). Reliable clinical predictors for antidepressant responses to rTMS remain elusive. Methods In total, 212 patients with MDD who failed to respond to at least one adequate antidepressant trial and had a detailed evaluation before rTMS were recruited for chart review. Demographic data, clinical characteristics, psychiatric comorbidities, symptom ratings [e.g., objective and subjective depression, life stress, depression refractoriness by Maudsley Staging Method (MSM)], and antidepressant treatment responses were analyzed. Results MSM-subitem1 (duration of current depressive episode; Beta = 0.209, p = 0.004), MSM-subitem5 (a history of ECT treatment; Beta = –0.210, p = 0.004), and psychiatric admissions (Beta = 0.241, p = 0.001) predicted antidepressant response of rTMS treatment. ECT was underutilized (only 3.3%). Psychiatric admissions [Exp(B) = 1.382, p = 0.021], a comorbidity of OCD [0.047, 0.005], and life stress level [0.984, 0.029] predicted the history of ECT treatment. Conclusion Several clinical variables (e.g., number of psychiatric admissions, OCD as a comorbidity, and life stress level) were reliable clinical factors associated with antidepressant responses of rTMS treatment and may be utilized in combination with MSM subitems to evaluate levels of TRD.
Corrections to "SiamFT: An RGB-Infrared Fusion Tracking Method via Fully Convolutional Siamese Networks"

In [1] , an error was created during the preparation of the final files. This only affected Figure 5 and had no influence on the discussion and conclusions in the paper. The correct graphs of Figure 5 are given below. Two examples of modality weights computed using the proposed method are presented. In the first one, the target (car) is clear in the first frame and gradually becomes unclear due to over-exposure. In the second example, it is difficult to see the target from visible images due to darkness, whereas it is easy to locate the target in infrared images. It can be seen clearly that the computed modality weights indeed indicate different reliability degrees of two modalities.
Parental smartphone addiction and adolescent smartphone addiction by negative parenting attitude and adolescent aggression: A cross-sectional study

Introduction This study aimed to examine the mediating role of negative parenting attitudes and adolescent aggression in the relationship between parents' and adolescents' smartphone addiction. Methods This was a cross-sectional descriptive study that used data from the 2018 Korean Children and Youth Panel Survey. The study involved 2,360 adolescents (1,275 boys, 54.0%, mean age 14.52 ± 0.33 years) and their parents (2,148 mothers, 91.0%), who used smartphones. Adolescents completed questionnaires assessing negative parenting attitudes, aggression, and smartphone addiction while parents completed questionnaires assessing their sociodemographic characteristics and smartphone addiction. Results Parents' smartphone addiction was directly and indirectly related to adolescents' smartphone. Additionally, negative parenting attitudes and adolescent aggression played serial mediating roles in the relationship between parents' smartphone addiction and adolescent smartphone addiction. Conclusion The findings suggest that it is necessary to consider parental smartphone addiction, parenting attitude, and adolescent aggression, when developing interventions to prevention smartphone addiction among adolescents. Moreover, it highlighted the importance of developing healthy parenting environment that includes parents' healthy smartphone use and positive parenting to prevent adolescents' smartphone addiction.