Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of essential oil from plants on migratory activity of Sitophilus granarius and Tenebrio molitor

Measures against pests should be performed in the context of integrated management of agricultural crops and complex control of pests. Therefore, use of ecologically safe approaches is the best option. Essential oils of plants can make an impact on the main metabolic, biochemical, physiological and behavioural functions of insects. We evaluated the effect of 18 essential oils and 18 dried plants on migratory activity of Sitophilus granarius (Linnaeus, 1758) and Tenebrio molitor Linnaeus, 1758 in conditions of laboratory experiment. Notable repellent activity against S. granarius was exhibited by Citrus sinensis and Picea abies. Repellent action against T. molitor was displayed by dried and cut leaves of Origanum vulgare and Eucalyptus globulus, and also essential oils from Juniperus communis, Р. abies, Pterocarpus santalinus, C. sinensis and C. aurantiifolia. Therefore, out of 18 studied essential oils, only two samples had a notable biological effect on migratory activity of S. granarius and five samples – on T. molitor. These data indicate a possibility of using essential oils or their main components as ecologically safe natural repellents against pests of stored wheat and products of its processing.
Da operação clássica de serviços à era da transformação digital e os desafios para o Serviço 4.0

Em busca de um diferencial frente aos seus concorrentes, as empresas se vêem obrigadas a explorar o potencial de crescimento com base na inovação. Impulsionando esse movimento, a transformação digital torna-se um paradigma no desenvolvimento de aplicação de inovações e tecnologias, seja no ramo da manufatura ou de serviços. O período considerado como quarta revolução industrial, ou como atualmente está sendo denominada – Indústria 4.0, tornou-se recentemente referência no desenvolvimento e na aplicação de inovações e tecnologias nos processos de manufatura. Como pilares da Indústria 4.0 destacam-se os Sistemas Cyber Físicos, a Internet das Coisas e a Internet de Serviços. Similarmente, o Serviço 4.0 é um termo que reúne tecnologias e conceitos de serviço, baseados em inovações disruptivas como Big Data, Mobilidade, Internet das Coisas e Internet de Serviços. Este artigo visa explanar as diferentes dimensões da Transformação Digital e suas interseções no âmbito do setor de Serviços. Através da integração desses conceitos, o artigo propõe um modelo conceitual que visa definir o termo Serviço 4.0 e mostrar os desafios da sua implementação em um cenário cada vez mais interconectado.
Exploitation of Elliptical Polarization for Improved Orthogonal Static Links

Orthogonal static or fixed links with polarization multiplexing can be formed by using dual-polarized antennas with a low cross-coupling from one polarization to the other. This is limited by the level of achievable polarization purity of two orthogonal dual-polarized antennas. Any practical antenna is inherently elliptically polarized (EP), resulting in either circular or linear polarization (LP) impurity. This article exploits such impurity where simple semi-directional EP antennas are designed to have minimal cross-coupling. The results show that a dual polar static link can reach the capacity limit using EP, which is not reached with LP. Channel measurements in both free-space and indoor environments were carried out from 2.2 to 2.4 GHz using a derived cross-polar ratio to quantify the impact of multipath scattering on static links.
Hospitalizations and re-Hospitalizations Due to Tuberculosis: Economic Costs and Spatial Distribution Analysis in an Endemic Northeastern City, Brazil

Introduction: In Brazil, preventable hospitalizations and re-hospitalizations due to tuberculosis represent increased costs for the health system. The aim was to analyze the sociodemographic and clinical profile of individuals who needed preventable hospitalizations and re-hospitalizations due to tuberculosis, the costs to the local health system, and the spatial pattern for the occurrence of these events in a Brazilian endemic city. Methods: Descriptive and exploratory study conducted in Natal, city located in the Northeast region of Brazil. The population comprised all cases of preventable hospitalizations and re-hospitalizations due to tuberculosis occurring between 2008 and 2013 obtained from the Hospital Information System. The neighborhoods and census tracts were chosen as the geographical units. Descriptive statistics and non-parametric tests were applied. Position and dispersion measures were used to analyze the costs. The gross rates were estimated, softened by the Global Empirical Bayesian Method. The Global and Local Moran indices were used to evaluate the spatial dependency. Results: 569 cases of hospitalizations due to tuberculosis were identified: 97.4 % were pulmonary form; 62.0% between 30 and 59 years old; 77.7% male; 87.3% mulatto. In the total group of hospitalizations, 13.4% died and 17.9% were readmitted. In total, US$ 470,370.07 was spent on preventable hospitalizations and re-hospitalizations due to tuberculosis, with an annual mean cost of US$ 78,395.01, median amounts of US$ 392.70 per hospitalization and US$ 1,342.19 per re-hospitalization. The spatial distribution of the events was not random, with high rates identified in neighborhoods of the East and West Health Districts. Conclusions: The non-randomness in the spatial pattern of preventable hospitalizations and re-hospitalizations cases due to tuberculosis suggests frailty in the access to Primary Health Care and appoints vulnerable spatial areas to these events. The recognition of these areas can contribute to public management in the improvement of health service access and to the equitable and efficient use of health resources, aiming to reduce the hospitalization costs.
Variation Analysis of Root System Development in Wheat Seedlings Using Root Phenotyping System

Root system architecture is a vital part of the plant that has been shown to vary between species and within species based on response to genotypic and/or environmental influences. The root traits of wheat seedlings are critical for their establishment in soil and evidently linked to plant height and seed yield. However, plant breeders have not efficiently developed the role of RSA in wheat selection due to the difficulty of studying root traits. We set up a root phenotyping platform to characterize RSA in 34 wheat accessions. The phenotyping pipeline consists of the germination paper-based moisture replacement system, image capture units, and root-image processing software. The 34 accessions from two different wheat ploidy levels (hexaploids and tetraploids), were characterized in ten replicates. A total of 19 root traits were quantified from the root architecture generated. This pipeline allowed for rapid screening of 340 wheat seedlings within 10 days. At least one line from each ploidy (6× and 4×) showed significant differences (p < 0.05) in measured traits, except for mean seminal count. Our result also showed a strong correlation (0.8) between total root length, maximum depth and convex hull area. This phenotyping pipeline has the advantage and capacity to increase screening potential at early stages of plant development, leading to the characterization of wheat seedling traits that can be further examined using QTL analysis in populations generated from the examined accessions.
A Phase 2 Dose Regimen Optimization Study of Three Schedules of Voreloxin as Single Agent Therapy for Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia.

A PHASE 2 DOSE REGIMEN OPTIMIZATION STUDY OF THREE SCHEDULES OF VORELOXIN AS SINGLE AGENT THERAPY FOR ELDERLY PATIENTS WITH NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA F Ravandi1, H Kantarjian1, L Cripe2, M Maris3, M Cooper4, S Dakhil5, R Stone6, D DeAngelo6, M Wadleigh6, F Turturro7, K Mahadocon8, J Fox8, G Michelson8, R Stuart9 1MD Anderson Cancer Center, Houston, TX; 2Indiana University Cancer Center, Indianapolis, IN; 3Rocky Mountain Bone Marrow Transplant Program, Denver, CO; 4St. Francis Hospital, Indianapolis, IN; 5Cancer Center of Kansas, Wichita, KS; 6Dana Farber Cancer Institute, Boston, MA; 7LSU Health Sciences Center, Shreveport, LA; 8Sunesis Pharmaceuticals, Inc., South San Francisco, CA; 9Medical University of South Carolina, Charleston, SC
The corrosion of character scale development: a validity and reliability study

The aim of this study is to develop a scale that determines the “Corrosion of Character” levels of research assistants. In the development process of the scale draft was presented to the evaluation of expert views. After the scope validity processes held via Lawshe analysis, seven items were taken out of the scale and four items were added. Totally 312 research assistants working at different private and state universities in Istanbul were subjected to the draft scale, which was comprised of 50 items in the 2018-2019 academic year. In the light of the data analysis, it was observed that the KMO value was . 88 and the data set was suitable for the factorization. In order to detect the structural validity of the scale, Principle Components and Exploratory Factor Analysis (EFA) were conducted and in the end “Corrosion of Character Scale” showed a four-factored (belongingness, precarity, scud, individuality) structure with an eigenvalue of over 1.00, and Cronbach’s alpha (.90) coefficients for the totality of the scale were observed. As a result of the Confirmatory Factor Analysis (CFA) applied, the fit indices were found as an acceptable level (x2/df=2.6, RMSEA=.06, GFI=.90, CFI=.92, TLI=.91). The results obtained prove that the “Corrosion of Character Scale” as a measurement tool is valid and reliable.
Oxidative Damage to Various Root and Shoot Tissues of Durum and Soft Wheat Seedlings during Salinity

The toxicity of high concentrations of sodium chloride creates significant difficulties in realizing the productivity potential of wheat. The development of effective test systems for the identification and selection of resistant genotypes is an urgent task given the global increase in soil salinity in agricultural land. To identify the characteristics of the plant’s reaction to the toxic effect of sodium chloride, wheat genotypes with different resistance to ionic toxicity (the Orenburgskaya 10 and Orenburgskaya 22 varieties) were used. In model experiments, we used fluorescence, light-optical and electron microscopy to characterize the structural and functional features of the cells of the roots of wheat seedlings, and cytological markers suitable for creating a test system for the early diagnosis of the sensitivity of wheat genotypes to sodium chloride were established. The response of the plants to the effects of sodium chloride was assessed by changes in biometric data, respiration rate, peculiarities in the accumulation of reactive oxygen species (ROS) and mitochondrial staining, and the quantitative assessment of coleoptile cell viability as putative sensitivity markers. In the sodium chloride-sensitive genotype (Orenburgskaya 10), toxic effects resulted in oxidative damage in the root cells, while in the resistant genotype (Orenburgskaya 22), oxidative damage to the cells was minimal. A high level of expression of mitochondrial superoxide dismutase (MnSOD) was found in the roots of the Orenburgskaya 22 variety. The identification and functional analysis of cytological and molecular markers provide the basis for further studies of the resistance of wheat to sodium chloride stress.
Morita Equivalence and Generalized Kähler Geometry

Morita Equivalence and Generalized Kähler Geometry Francis Bischoff Doctor of Philosophy Graduate Department of Mathematics University of Toronto 2019 Generalized Kähler (GK) geometry is a generalization of Kähler geometry, which arises in the study of super-symmetric sigma models in physics. In this thesis, we solve the problem of determining the underlying degrees of freedom for the class of GK structures of symplectic type. This is achieved by giving a reformulation of the geometry whereby it is represented by a pair of holomorphic Poisson structures, a holomorphic symplectic Morita equivalence relating them, and a Lagrangian brane inside of the Morita equivalence. We apply this reformulation to solve the longstanding problem of representing the metric of a GK structure in terms of a real-valued potential function. This generalizes the situation in Kähler geometry, where the metric can be expressed in terms of the partial derivatives of a function. This result relies on the fact that the metric of a GK structure corresponds to a Lagrangian brane, which can be represented via the method of generating functions. We then apply this result to give new constructions of GK structures, including examples on toric surfaces. Next, we study the Picard group of a holomorphic Poisson structure, and explore its relationship to GK geometry. We then apply our results to the deformation theory of GK structures, and explain how a GK metric can be deformed by flowing the Lagrangian brane along a Hamiltonian vector field. Finally, we prove a normal form result, which says that locally, a GK structure of symplectic type is determined by a holomorphic Poisson structure and a time-dependent real-valued function, via a Hamiltonian flow construction.
Recent Research Topics in Nuclear Cardiology from the YIA Session of JSNC 2015

The Young Investigator Award (YIA) competition session is one of the highlights of the Japanese Society of Nuclear Cardiology (JSNC) annual scientific meeting. Beginning in 2014, the top 3 abstracts submitted to the JSNC annual meeting by candidates under the age of 40 have been considered for the YIA. At the 2015 YIA session, these candidates presented abstracts on the latest important research topics in nuclear cardiology. These topics included phase analysis in chronic kidney disease, cardiac sarcoidosis, and risk assessment using myocardial perfusion imaging.
Aktuální pohled na diagnostiku a léčbu folikulárního lymfomu

Folikularni lymfom (FL) představuje nejcastějsi indolentni ne-hodgkinův lymfom. Přestože je stale považovan za nevylecitelne onemocněni, u pacientů s pokrocilou chorobou bylo aktualně zaznamenano prodlouženi celkoveho přežiti. Mezinarodni prognostický index pro FL (FLIPI) je robustni prognostický nastroj, jehož platnost byla potvrzena i v eře rituximabu. FLIPI, biologicke proměnne a histologický grading mohou pomoci diferencovat pacienty s vysokým rizikem casneho navratu FL respektive casne transformace. Tyto nastroje take usnadni možnost rozpoznat, kteři pacienti s pokrocilým avsak asymptomatickým onemocněnim by měli být ihned leceni, a kteři pouze sledovani („watch and wait“ strategie). Rituximab podstatně změnil lecebne postupy u folikularniho lymfomu, přicemž největsi přinos je patrný v kombinacni lecbě s chemoterapii a v zavedeni udržovaci lecby pro relabujici nemocne. Problemem zůstava rekurentni ci rezistentni choroba (vcetně FL refrakterniho k rituximabu), v tomto připadě je jako standardni lecba indikovana radioimunoterapie, autologni nebo alogenni transplantace kostni dřeně.
Endoplasmic reticulum (ER) lumenal indicators in Drosophila reveal effects of HSP-related mutations on ER calcium dynamics

Genes for ER-shaping proteins are among the most commonly mutated in Hereditary Spastic Paraplegia (HSP). Mutation of these genes in model organisms can lead to disruption of the ER network. To investigate how the physiological roles of the ER might be affected by such disruption, we developed tools to interrogate its Ca2+ signaling function. We generated GAL4-driven Ca2+ sensors targeted to the ER lumen, to record ER Ca2+ fluxes in identified Drosophila neurons. Using GAL4 lines specific for Type Ib or Type Is larval motor neurons, we compared the responses of different lumenal indicators to electrical stimulation, in axons and presynaptic terminals. The most effective sensor, ER-GCaMP6-210, had a Ca2+ affinity close to the expected ER lumenal concentration. Repetitive nerve stimulation generally showed a transient increase of lumenal Ca2+ in both the axon and presynaptic terminals. Mutants lacking neuronal reticulon and REEP proteins, homologs of human HSP proteins, showed a larger ER lumenal evoked response compared to wild type; we propose mechanisms by which this phenotype could lead to neuronal dysfunction or degeneration. Our lines are useful additions to a Drosophila Ca2+ imaging toolkit, to explore the physiological roles of ER, and its pathophysiological roles in HSP and in axon degeneration more broadly.
The unexpected high risk of occurrence or recurrence of hepatocellular carcinoma after successful antiviral therapy with interferon-free direct-acting antivirals

Chronic hepatitis C (CHC) infection is one of the major etiologies of hepatocellular carcinoma (HCC). In the previous era of interferon-based therapy, successful viral eradication has greatly reduced the risk of disease progression and HCC occurrence (1-3). Around three quarters of HCC events may be prevented at all stages of liver fibrosis (1,4,5), even among patients with compensated liver cirrhosis (6). On the hand, the effect of interferon-based antiviral therapy in tertiary prevention of HCC recurrence is much more controversial (7-11), which may attribute to heterogeneous patient characteristics and study designs.
Social Security Membership and Saving: The Turkish Case

Bu calisma Turkiye’de tasarruf oranlarinda kambur bir profil olup olmadigini inceleyerek tasarrufun mikro temellerini arastirmaktadir. Hanehalki Butce Anketleri kullanilarak bir yapay panel veri seti olusturulmustur. Daha sonra yas-kohort-zaman ayristirmasi ile Turkiye’de tasarruf oraninin yasa bagli davranisi incelenmistir. Analiz, sosyal guvenlik sistemi uyeligine gore olusturulan alt orneklemler icin tekrarlanmistir. Kesikli inceleme de yapilarak analiz derinlestirilmistir. Kambur bir profilin varligi teyid edilmistir fakat kambur profilin varligi ile sosyal guvenlik uyeligi arasinda duzenli bir baginti gozlemlenmemistir.
Incidence and risk factors for pelvic lymph node metastasis in early-stage endometrial cancer: a retrospective study

Objective: We aimed to determine the incidence and risk factors of pelvic lymph node metastasis in patients with presumably early-stage endometrial cancer in a hospital in Hong Kong. Methods: We retrospectively reviewed medical records of patients with endometrial cancer confined to the uterus who underwent total hysterectomy with bilateral salpingo-oophorectomy, with or without pelvic lymphadenectomy at Tuen Mun Hospital between 1 January 2011 and 31 December 2015. Patients with gross uterine serosa involvement, extrauterine disease, synchronised ovarian cancers, or sarcomatous tumour (adenosarcoma and endometrial stromal sarcoma) were excluded. Pelvic lymph node metastasis is defined as the presence of metastasis in the excised lymph nodes or within 12 months if pelvic lymphadenectomy was not performed. Results: Of 268 patients (mean age, 54.8 years), 249 (92.8%) had endometrioid or mucinous adenocarcinoma, 14 (5.3%) had serous or clear cell carcinoma, and 5 (1.9%) had carcinosarcoma. Overall, 33 (12.5%) patients had highgrade pathology. 179 (66.8%) patients underwent pelvic lymphadenectomy with a mean of 25.2 (range, 7-85) pelvic lymph nodes removed; 16 of them had pelvic lymph node metastasis. Among the remaining 89 patients with no pelvic lymphadenectomy, 14 had selective lymph node sampling and 2 of them had pelvic lymph node metastasis. The incidence of pelvic lymph node metastasis in our cohort was 6.7% (n=18). In univariate logistic regression, large tumour size, deep myometrial invasion, cervical stromal invasion, and lymphovascular space invasion were significant risk factors of pelvic lymph node metastasis. In multivariate logistic regression, only large tumour size (adjusted OR=9.18, 95% CI=1.12-75.48, p=0.039) and cervical stromal invasion (adjusted OR=5.14, 95% CI=1.7215.3, p=0.003) were significant independent risk factors. Conclusion: Large tumour with maximal tumour diameter >2 cm and cervical stromal invasion are independent risk factor for pelvic lymph node metastasis in patients with early-stage endometrial cancer. Pelvic lymphadenectomy may not be necessary in patients with small tumour and absence of cervical involvement, especially when there is no evidence of high-grade pathology or deep myometrial invasion.
Heat tolerant epoxy-amine functionalized graphene oxide composites for insulation applications

Abstract Heat tolerant polymers are in much demand in electrical, structural, and electronic packaging applications. This article reports on a comparison of epoxy composites reinforced with graphene oxide (GO) and amine-functionalized GO (AGO) on their dielectric properties and adhesive strength in the temperature range of 30–110 °C. GO was synthesized using the modified Hummers method and functionalized with amine functional group using hexamethylenediamine (HMDA) and confirmed by Raman spectroscopy. Various filler concentrations (0.2–0.6 wt.%) of GO/AGO epoxy nanocomposites were prepared using the solution blending method and analyzed using a dynamic mechanical analyzer (DMA), impedance spectroscopy, and the single lap shear (SLS) test. Studies showed AGO reinforced epoxy composites outperforming than neat epoxy and GO-epoxy composites for all the compositions. The optimum concentration of AGO was found to be 0.4 wt. % based on its relative permittivity, dielectric loss and retention of adhesive strength up to 90 °C. The percentage of cohesive area on the fractured surface of SLS tested AGO was ∼1.4 and ∼3 times better than that of GO-epoxy and neat epoxy, respectively. The higher strength retention of AGO-epoxy nanocomposites is suitable for high-temperature insulation applications as adhesive coatings.
Financial Stability with Sovereign Debt

Are government guarantees or fnancial regulation a more effective way to prevent banking crises? I study this question in the presence of a negative feedback loop between the fscal position of the government and the health of the banking sector. I construct a model of fnancial intermediation in which the government issues, and may default on, debt. Banks hold some of this debt, which ties their health to that of the government. The government's tax revenue, in turn, depends on the quantity of investment that banks are able to fnance. I compare the effectiveness of government guarantees, liquidity regulation, and a combination of these policies in preventing self-fulflling bank runs. In some cases, a combination of the two policies is needed to prevent a run. In other cases, liquidity regulation alone is effective and adding guarantees would make the fnancial system fragile.
AStarix: Fast and Optimal Sequence-to-Graph Alignment

We present an algorithm for the optimal alignment of sequences to genome graphs. It works by phrasing the edit distance minimization task as finding a shortest path on an implicit alignment graph. To find a shortest path, we instantiate the A⋆ paradigm with a novel domain-specific heuristic function that accounts for the upcoming subsequence in the query to be aligned, resulting in a provably optimal alignment algorithm called AStarix. Experimental evaluation of AStarix shows that it is 1–2 orders of magnitude faster than state-of-the-art optimal algorithms on the task of aligning Illumina reads to reference genome graphs. Implementations and evaluations are available at https://github.com/eth-sri/astarix.