Miracle-dz/UniFAR-FTUs huggingface dataset:
Biodistribution and Radiation Dosimetry of Deuterium-Substituted 18F-Fluoromethyl-[1, 2-2H4]Choline in Healthy Volunteers

11C-choline and 18F-fluoromethylcholine (18F-FCH) have been used in patients to study tumor metabolic activity in vivo; however, both radiotracers are readily oxidized to respective betaine analogs, with metabolites detectable in plasma soon after injection of the radiotracer. A more metabolically stable FCH analog, 18F-fluoromethyl-[1,2-2H4]choline (18F-D4-FCH), based on the deuterium isotope effect, has been developed. We report the safety, biodistribution, and internal radiation dosimetry profiles of 18F-D4-FCH in 8 healthy human volunteers. Methods: 18F-D4-FCH was intravenously administered as a bolus injection (mean ± SD, 161 ± 2.17 MBq; range, 156–163 MBq) to 8 healthy volunteers (4 men, 4 women). Whole-body (vertex to mid thigh) PET/CT scans were acquired at 6 time points, up to 4 h after tracer injection. Serial whole-blood, plasma, and urine samples were collected for radioactivity measurement and plasma radiotracer metabolites. Tissue 18F radioactivities were determined from quantitative analysis of the images, and time–activity curves were generated. The total numbers of disintegrations in each organ normalized to injected activity (residence times) were calculated as the area under the curve of the time–activity curve normalized to injected activities and standard organ volumes. Dosimetry calculations were performed using OLINDA/EXM 1.1. Results: The injection of 18F-D4-FCH was well tolerated in all subjects, with no radiotracer-related serious adverse event reported. The mean effective dose averaged over both men and women (±SD) was estimated to be 0.025 ± 0.004 (men, 0.022 ± 0.002; women, 0.027 ± 0.002) mSv/MBq. The 5 organs receiving the highest absorbed dose (mGy/MBq) were the kidneys (0.106 ± 0.03), liver (0.094 ± 0.03), pancreas (0.066 ± 0.01), urinary bladder wall (0.047 ± 0.02), and adrenals (0.046 ± 0.01). Elimination was through the renal and hepatic systems. Conclusion: 18F-D4-FCH is a safe PET radiotracer with a dosimetry profile comparable to other common 18F PET tracers. These data support the further development of 18F-D4-FCH for clinical imaging of choline metabolism.
Miniaturized 122 GHz short range radar sensor with antenna-in-package (AiP) and dielectric lens

This paper shows a SiGe single chip radar sensor with high efficient LCP off-chip antennas integrated in a standard QFN package at a center frequency of 122.5 GHz. The millimeter-wave interconnect is performed by a CPW bond-wire connection with subsequent matching network. For demonstration purposes a complete baseband processing and RF unit is implemented on a PCB and integrated in a plastic housing where a focusing HDPE lens with a directivity of 30.7 dBi for gain enhancement can be connected. Distance measurements in a real world scenario are performed from 0.4-18.25m and 0.6-14.5m for a metal plate and a wooden plate, respectively. Additionally, a velocity measurement from 0.5-5m/s in the laboratory is performed.
Noise discrimination from PD signal in pre-breakdown discharge detection test

In Japan, 22-77 kV cross-linked polyethylene (XLPE) cables have been put into practical use for about 40 years, and some of them have been in operation for more than 30 years, which exceeds their expected lifespans of 30 years. At these voltage levels, the degradation of the insulation of XLPE cables is due mainly to the water tree. Central Research Institute of Electric Power Industry (CRIEPI) has studied the dielectric strength of XLPE cables and the various aspects of water tree degradation using a pre-breakdown discharge detection (PBPD test). This test's success rate of whether to find the water tree of weakest point in cable specimen depends on a method that distinguishes small partial discharge (PD) signals caused by water trees from noises in noisy environments of the test field. It also determines the likelihood of establishing a robust PBPD test that incorporates the developed method for the discrimination of PD signals from noises.
Mechanism of activation of transcription by the complex formed between cyclic AMP and its receptor in Escherichia coli.

and single-strand-specific cleavage. The two open complexes produce identical deoxyribonuclease I footprints and similar methylation interference/protection (one base shows different behaviour), indicating that both complexes are at the same binding site. The two open complexes, however, differ in the amount of unwinding in the 13 to + 3 region, as assayed by probes for singlestranded DNA. A functional assay, transcription within the gel slices containing the open complexes, indicates that the open complexes also differ in the ability to escape from the abortive initiation cycle into productive transcription. The upper gel band 0, has a lower total RNA synthesis rate but a greater relative production of the stably bound 1 1-mer compared with the abortive 8-mer product. Dominance of 0, at higher temperature may reflect an adaptive mechanism to counter the observed tendency of abortive initiation to increase with increasing temperature. The results are summarized in the scheme shown in Fig. 1. Deoxyribonuclease I footprinting of the initiated complex containing only the first stable transcript (the 1 1-mer) shows a contraction from the open-complex footprints by loss of approximately 25 bp of contacts in the 35 region, and loss of the o-subunit. This drastic structural change, and the measured apparent activation energy for abortive release of nascent RNA transcripts, lead us to propose a model which features an energetically stressed intermediate in the translocation of polymerase away from its contact in the 35 region. The model focuses on mutually competitive interactions of polymerase with the 35 region or with short transcripts in the 0 to + 10 region; the stability of the RNA-DNA hybrid double helix formed by the pascent transcripts can also be expected to affect the relative importance of abortive initiation.
A study on the influence of personality and anonymity on electronic brainstorming

This study examines the influence of personality and anonymity on idea generation in electronic brainstorming systems. A hypothesis was set up that anonymity encourages introverts to generate ideas in electronic brainstorming, and this hypothesis was examined by a laboratory experiment and questionnaire. The subjects of this experiment were 20 university students and graduate students who had studied and used groupware systems. 2/spl times/2 factorial design was used, crossing anonymity (anonymous/identified) with personality (introvert/extravert). As for the results of the laboratory experiment, introverts with anonymity generated a lot of ideas. As for the results of the questionnaire, it was clarified that the anonymous condition in electronic brainstorming is suited to introverts' idea generation. So, in this study the hypothesis was basically supported. Generally speaking, Japanese are, like introverts, sensitive to conformance pressure. So, the anonymous condition may be most suited to Japanese people. In the future, the relationship between anonymity and cultural background should be studied.
Increasing Risks of Introduction of Heartwater onto the American Mainland Associated with Animal Movements

Abstract: Opportunities to introduce heartwater onto the American mainland through animal movements include importation from Africa of tick‐infested reptiles and of subclinically infected wild ungulates and importation of livestock from islands in the Caribbean infested with Amblyomma variegatum ticks. Measures to control importation of heartwater vectors on reptiles include importation bans of infested species, treatment of imported reptiles, and eradication of established infestations on the American mainland. Measures to control importation of infected wildlife must focus on improved methods, such as the PCR assay, of screening animals to prevent the entry of carriers of Cowdria ruminantium. Measures to control importation of infected animals from the Caribbean must be based on knowledge of the islands that are infected with C. ruminantium so that the risk of dissemination of heartwater can be established.
Energy Harvesting and Information Transmission Protocol in Sensors Networks

We focus on the design of transmission protocol for energy harvesting wireless sensors. The sensors can harvest the energy from the environment, but they cannot charge and discharge at the same time. We propose a protocol for energy harvesting and wireless transmission, which contains two steps. In the first step, the sensor harvests the energy from environment, and the energy harvesting rate is controlled by the harvested energy power of the energy saving device (ESD). In the second step, some data should be transmitted to the receiver in a certain time. Considering one slot time, the first part of the time is devoted exclusively to energy harvesting, and the remaining time of the slot is for transmitting the information data. Assume that Q bits are transmitted to the receiver within one time slot; we establish the relationship between the harvesting energy time and the transmit data time. In addition, we analyze the system outage probability performance over the Rayleigh fading channel.
Spectroscopic and Characterization ofMedical and Physical Applications of MetalComplexes of Schiff bases in nano-sized Shape:Mg(II), Ca(II) and Ba(II) Schiff baseComplexes

Mg(II), Ca(II) and Ba(II) metal chelates with formulas, (Mg(HL)2(Cl)2). 6H2O, (Ca(HL)2(Cl)2). 2H2O and (Ba(HL)2(H2O)2). Cl2.2H2O thatHL is the Schiff base moiety formed from condensation of 2-thiophenecarboxaldehyde with 2-chlorophenyl hydrazine have been prepared and characterized by elemental analysis and spectroscopic measurements (infrared and 1 H-NMR). Elemental analysis of the complexes suggests the stoichiometry is 1:2 (metal- ligand). Infrared spectra of the complexes agree with the coordination to the central metal atom through the nitrogen of the 2-chlorophenyl hydrazine(-Ph-NH-) group and the sulfur atom of the thiophene ring. Biological properties of prepared compounds were studied included antimicrobial activity and cytotoxicity. A potent antimicrobial activity evaluated by disc inhibition zone and variety degree of activity recorded against gram-positive; gram-negative and fungal strains. Cytotoxicity against two cell lines; MCF-7 and HePG-2 were evaluated and IC50 values were calculated. The (Ba(HL)2(H2O)2). Cl2.2H2O and (Mg(HL)2(Cl)2). 6H2O had the highest antitumor effect with IC50 values; 32.6 and 30. 4µg/ml for MCF-7 cell line and 37.5 ; 39.5 µg/ml for HePG-2 cell line.
An Improved ZVT PWM Three Level Boost Converter for Power Factor Preregulator

An improved ZVT PWM three level boost converter for power factor preregulator is proposed in this paper. Only one auxiliary switch is used in the active soft switching circuit. By using this ZVT converter topology, zero voltage turn-on and zero voltage turn-off of the main switches can be achieved and the reverse-recovery loss of boost diode can be reduced. In addition, the auxiliary switch is ZCS during the turn-on switching transition and zero voltage turn-off. A prototype of boost converter rated at 420 W has been built to confirm the effectiveness of the converter.
Switched-beam antenna based on EBG periodic structures

This paper presents the design and the fabrication of a new switched beam antenna based on Electromagnetic BandGap (EBG) periodic structures. For this purpose, two different frequency selective surfaces are analyzed and their geometric and electromagnetic (EM) dualities are assessed. Then, these FSS structures are used to achieve EBG structures with controllable features. These agile structures are considered for the design of a switched beam antenna. The antenna is operating at 1.8GHz and presents a gain of 10dBi with 60° of beam-width in azimuth plane and the possibility to generate and switch between six different beams and cover 360°. Finally experimental results are presented and discussed. This system is suitable for smart antenna systems.
Predicting the equilibrium protein folding pathway: Structure‐based analysis of staphylococcal nuclease

The equilibrium folding pathway of staphylococcal nucleas (SNase) has been approximated using a statistical thermodynamic formalism that utilizes the high‐resolution structure of the native state as a template to generate a large ensemble of partially folded states. Close to 400,000 different states ranging from the native to the completely unfolded states were included in the analysis. The probability of each state was estimated using an empirical structural parametrization of the folding energetics. It is shown that this formalism predicts accurately the stability of the protein, the cooperativity of the folding/unfolding transition observed by differential scanning calorimetry (DSC) or urea denaturation and the thermodynamic parameters for unfolding. More importantly, this formalism provides a quantitative account of the experimental hydrogen exchange protection factors measured under native conditions for SNase. These results suggest that the computer‐generated distribution of states approximates well the ensemble of conformations existing in solution. Furthermore, this formalism represents the first model capable of quantitatively predicting within a unified framework the probability distribution of states seen under native conditions and its change upon unfolding. © 1997 Wiley‐Liss, Inc.
ACTOMYOSIN CONTENT OF THE HUMAN PLACENTA

The total soluble protein and the concentration of the contractile protein actomyosin were estimated in the human placenta at varying stages of gestation. As maturity and differentiation of the placenta occurred the proteins increased in concentration. The actomyosin was thought to be present in the smooth muscle fibres in the chorionic plate, and related to the placental vessel walls. The contractile property of the smooth muscle and the demonstration of contractile protein suggested that they play an active role in the dynamics of placental circulation.
Distribution of HLA‐DRB1 and HLA‐DQB1 families of alleles and haplotypes in Vojvodina population

Major histocompatibility complex encoding human leucocyte antigens (HLA) is a highly polymorphic gene cluster that makes it a valuable tool in the population genetic studies. The aim of our study was to compare HLA class II gene frequencies with other populations from Europe and to determine the relationship between the investigated populations. In this study, one hundred and twenty healthy individuals from Vojvodina, northern Serbia, were studied for 18 of the HLA‐DRB1 and HLA‐DQB1 loci. The HLA families of alleles were analysed by using sequence‐specific primers for polymerase chain reaction (PCR‐SSP). The results showed the increased frequency of HLA‐DRB1*11(0.333), ‐DRB1*04(0.300), ‐DRB1*07(0.250), ‐DQB1*03(0.730) and ‐DQB1* 05(0.391), among the tested families of alleles. The two‐locus haplotype analysis revealed significant positive linkage disequilibrium for DRB1*11DQB1*03 (Δ = 0.0788, χ2 = 12.61) and DRB1*04DQB1*03 (Δ = 0.0583, χ2 = 8.04). A phylogenetic tree constructed on the basis of the DRB1* gene frequencies derived from other populations revealed the clustering among the Vojvodina population together with other populations in Europe (Croats, Austrians and Hungarians). Close relationship of the Vojvodina population with the populations of Hungarians and Austrians can be the result of their historical influence on the region of Vojvodina.
Trichloroethylene and Cancer: Systematic and Quantitative Review of Epidemiologic Evidence for Identifying Hazards

We conducted a meta-analysis focusing on studies with high potential for trichloroethylene (TCE) exposure to provide quantitative evaluations of the evidence for associations between TCE exposure and kidney, liver, and non-Hodgkin lymphoma (NHL) cancers. A systematic review documenting essential design features, exposure assessment approaches, statistical analyses, and potential sources of confounding and bias identified twenty-four cohort and case-control studies on TCE and the three cancers of interest with high potential for exposure, including five recently published case-control studies of kidney cancer or NHL. Fixed- and random-effects models were fitted to the data on overall exposure and on the highest exposure group. Sensitivity analyses examined the influence of individual studies and of alternative risk estimate selections. For overall TCE exposure and kidney cancer, the summary relative risk (RRm) estimate from the random effects model was 1.27 (95% CI: 1.13, 1.43), with a higher RRm for the highest exposure groups (1.58, 95% CI: 1.28, 1.96). The RRm estimates were not overly sensitive to alternative risk estimate selections or to removal of an individual study. There was no apparent heterogeneity or publication bias. For NHL, RRm estimates for overall exposure and for the highest exposure group, respectively, were 1.23 (95% CI: 1.07, 1.42) and 1.43 (95% CI: 1.13, 1.82) and, for liver cancer, 1.29 (95% CI: 1.07, 1.56) and 1.28 (95% CI: 0.93, 1.77). Our findings provide strong support for a causal association between TCE exposure and kidney cancer. The support is strong but less robust for NHL, where issues of study heterogeneity, potential publication bias, and weaker exposure-response results contribute uncertainty, and more limited for liver cancer, where only cohort studies with small numbers of cases were available.
Triangle/Square Waveform Generator Using Area Efficient Hysteresis Comparator

A function generator generating both square and triangle waveforms is proposed. The generator employs only one low area comparator with accurate hysteresis set by a bias current and a resistor. Oscillation frequency and its non-idealitiesareanalyzed. Thefunctionoftheproposedcir- cuitisdemonstratedonadesignof1MHzoscillatorinSTMi- croelectronics 180 nm BCD technology. The designed cir- cuit is thoroughly simulated including trimming evaluation. It consumes 4. 1µA at 1.8V and takes 0.0126mm 2 of silicon area. The temperature variation from 40 C to 125 C is 1.5% and the temperature coecient is 127ppm = C.
Possible Involvement of Cyclophilin B and Caspase-Activated Deoxyribonuclease in the Induction of Chromosomal DNA Degradation in TCR-Stimulated Thymocytes1

TCR engagement of immature CD4+CD8+ thymocytes induces clonal maturation (positive selection) as well as clonal deletion (negative selection) in the thymus. However, the cell death execution events of thymocytes during the negative selection process remain obscure. Using a cell-free system, we identified two different DNase activities in the cytosol of in vivo anti-TCR-stimulated murine thymocytes: one that induced chromosomal DNA fragmentation, which was inhibited by an inhibitor of caspase-activated DNase, and another that induced plasmid DNA degradation, which was not inhibited by an inhibitor of caspase-activated DNase. We purified the protein to homogeneity that induced plasmid DNA degradation from the cytosol of anti-CD3-stimulated thymocytes and found that it is identical with cyclophilin B (Cyp B), which was reported to locate in endoplasmic reticulum. Ab against Cyp B specifically inhibited the DNA degradation activity in the cytosol of anti-CD3-stimulated thymocytes. Furthermore, recombinant Cyp B induced DNA degradation of naked nuclei, but did not induce internucleosomal DNA fragmentation. Finally, we demonstrated that TCR engagement of a murine T cell line (EL4) with anti-CD3/CD28 resulted in the release of Cyp B from the microsome fraction to the cytosol/nuclear fraction. Our data strongly suggest that both active caspase-activated DNase and Cyp B may participate in the induction of chromosomal DNA degradation during cell death execution of TCR-stimulated thymocytes.
Communication and computer networks - modelling with discrete-time queues

In this age of modern era, the use of internet must be maximized. Yeah, internet will help us very much not only for important thing but also for daily activities. Many people now, from any level can use internet. The sources of internet connection can also be enjoyed in many places. As one of the benefits is to get the on-line communication and computer networks modelling with discrete time queues book, as the world window, as many people suggest.
Mitigating amphibian chytridiomycoses in nature

Amphibians across the planet face the threat of population decline and extirpation caused by the disease chytridiomycosis. Despite consensus that the fungal pathogens responsible for the disease are conservation issues, strategies to mitigate their impacts in the natural world are, at best, nascent. Reducing risk associated with the movement of amphibians, non-amphibian vectors and other sources of infection remains the first line of defence and a primary objective when mitigating the threat of disease in wildlife. Amphibian-associated chytridiomycete fungi and chytridiomycosis are already widespread, though, and we therefore focus on discussing options for mitigating the threats once disease emergence has occurred in wild amphibian populations. All strategies have shortcomings that need to be overcome before implementation, including stronger efforts towards understanding and addressing ethical and legal considerations. Even if these issues can be dealt with, all currently available approaches, or those under discussion, are unlikely to yield the desired conservation outcome of disease mitigation. The decision process for establishing mitigation strategies requires integrated thinking that assesses disease mitigation options critically and embeds them within more comprehensive strategies for the conservation of amphibian populations, communities and ecosystems. This article is part of the themed issue ‘Tackling emerging fungal threats to animal health, food security and ecosystem resilience’.
Knowledge Capture and the Retirement of the Director of Finance: Succession Planning in the San Mateo County Human Services Agency

Concern over the impending retirement of several top-level managers led a county agency to engage in efforts aimed at more efficient succession management. Administrators developed plans to prevent the loss of invaluable knowledge and wisdom accompanying retirement of experienced agency leaders. The agency's Director of Finance (DoF) was one of the first key figures projected to retire, and a succession plan was implemented to transfer his knowledge for use after his departure. The knowledge transfer process involved three stages, including: (1) employing the DoF as teacher, having him develop curricula and conduct trainings; (2) engaging the DoF as mentor, allowing an existing staff member and the DoF's successor to shadow and be coached by the DoF; and (3) developing a knowledge management system that could be used after the DoF departed. This case study describes the knowledge transfer process and experiences shared by the DoF and this agency.