Miracle-dz/UniFAR-FTUs huggingface dataset:
Footwear Alters Lower Extremity Coordination Variability

Footwear has been shown to have a significant effect on numerous kinematic and kinetic variables during walking and running. While footwear mass is an indisputably important influence on gait patterns, we suspected that the amount of outsole material on most footwear would likely diminish or delay the integration of tactile feedback in motor control strategies during gait. Thus, we designed this study to investigate the influence of footwear and augmented tactile feedback on lower extremity coordination patterns during walking. A secondary purpose of the study was to examine gender differences in response to altered footwear conditions. Forty-eight participants (24 male and 24 females) walked during four standardized footwear conditions (barefoot, shod, barefoot with augmented tactile feedback, and shod with augmented tactile feedback), and we collected three-dimensional kinematic data and calculated continuous relative phase values for two adjacent lower extremity joints to determine interjoint coordination patterns. We used deviation phase and the mean of the continuous relative phase to compare motor coordination patterns across conditions. We found significant footwear and gender effects for spatiotemporal variables but only significant footwear effects for motor coordination patterns. Females displayed a significantly higher cadence and shorter height-normalized stride length as compared to males. Participants displayed significantly greater thigh-shank coordination variability in the shod, as compared to the unshod, conditions. Thus, footwear results in a diminished or delayed tactile feedback that alters neuromuscular control strategies during walking.
Large herbivore assemblages in a changing climate: incorporating water dependence and thermoregulation

Abstract The coexistence of different species of large herbivores (ungulates) in grasslands and savannas has fascinated ecologists for decades. However, changes in climate, land‐use and trophic structure of ecosystems increasingly jeopardise the persistence of such diverse assemblages. Body size has been used successfully to explain ungulate niche differentiation with regard to food requirements and predation sensitivity. But this single trait axis insufficiently captures interspecific differences in water requirements and thermoregulatory capacity and thus sensitivity to climate change. Here, we develop a two‐dimensional trait space of body size and minimum dung moisture content that characterises the combined food and water requirements of large herbivores. From this, we predict that increased spatial homogeneity in water availability in drylands reduces the number of ungulate species that will coexist. But we also predict that extreme droughts will cause the larger, water‐dependent grazers as wildebeest, zebra and buffalo–dominant species in savanna ecosystems – to be replaced by smaller, less water‐dependent species. Subsequently, we explore how other constraints such as predation risk and thermoregulation are connected to this two‐dimensional framework. Our novel framework integrates multiple simultaneous stressors for herbivores and yields an extensive set of testable hypotheses about the expected changes in large herbivore community composition following climate change.
[Effect of life style interventions over quality of life in colorectal cancer survivors].

INTRODUCTION One third of cancer deaths are related to poor diet, physical inactivity and obesity. The high healthcare costs of cancer treatment and its repercussions on the quality of life have led the scientific community to investigate a variety of other interventions. METHODS Review of experimental and observational studies of the last 5 years, including adult subjects surviving colorectal cancer, subjected to lifestyle interventions of a minimum duration of 12 weeks. The review was guided by the PRISMA statement (data extraction from PubMed, Science Direct and EBSCO: Medline Complete). The selection of the studies was completed using the Covidence platform. RESULTS There are positive associations between physical activity level and quality of life; on the other hand, in survivors of colorectal cancer, inverse relationships between time of sedentary attitude and quality of life are evidenced. CONCLUSION Lifestyle interventions generate an increase in quality of life indicators in survivors of colorectal cancer.
Research on two-phase chain store distribution vehicle routing problem with soft time windows

According to chain enterprises distribution routing optmization decision making problem,this paper established a mathematic model of the problem by using the decomposition method for two phase analysis,and introduced a time window constraints.First,the method determined the optimal number and locations of suppliers and distribution centers by using minimum wrap-net method,then used TS to search the optimal routes from distribution centers to stores.The test example shows the validity this method of and practical value.
Elucidation of the Molecular Mechanism Underlying Lippia citriodora(Lim.)-Induced Relaxation and Anti-Depression

Lippia citriodora ethanolic extract (VEE) and verbascoside (Vs), a phenypropanoid glycoside, have been demonstrated to exert relaxant and anxiolytic properties. However, the molecular mechanisms behind their effects are still unclear. In this work, we studied the effects and action mechanisms of VEE and Vs in vivo and in vitro, on human neurotypic SH-SY5Y cells.TST was conducted on mice treated orally with VEE (25, 50 and 100 mg/Kg), Vs (2.5 and 5 mg/Kg), Bupropion (20 mg/Kg) and Milli-Q water. Higher dose of VEE-treated mice showed an increase of immobility time compared to control groups, indicating an induction of relaxation. This effect was found to be induced by regulation of genes playing key roles in calcium homeostasis (calcium channels), cyclic AMP (cAMP) production and energy metabolism. On the other hand, low doses of VEE and Vs showed an antidepressant-like effect and was confirmed by serotonin, noradrenalin, dopamine and BDNF expressions. Finally, VEE and Vsenhancedcell viability, mitochondrial activity and calcium uptake in vitro confirming in vivo findings. Our results showed induction of relaxation and antidepressant-like effects depending on the administered dose of VEE and Vs, through modulation of cAMP and calcium.
A Guide on Deep Learning for Complex Trait Genomic Prediction

Deep learning (DL) has emerged as a powerful tool to make accurate predictions from complex data such as image, text, or video. However, its ability to predict phenotypic values from molecular data is less well studied. Here, we describe the theoretical foundations of DL and provide a generic code that can be easily modified to suit specific needs. DL comprises a wide variety of algorithms which depend on numerous hyperparameters. Careful optimization of hyperparameter values is critical to avoid overfitting. Among the DL architectures currently tested in genomic prediction, convolutional neural networks (CNNs) seem more promising than multilayer perceptrons (MLPs). A limitation of DL is in interpreting the results. This may not be relevant for genomic prediction in plant or animal breeding but can be critical when deciding the genetic risk to a disease. Although DL technologies are not “plug-and-play”, they are easily implemented using Keras and TensorFlow public software. To illustrate the principles described here, we implemented a Keras-based code in GitHub.
Effects of Suspension Versus Traditional Resistance Training on Explosive Strength in Elementary School-Aged Boys.

PURPOSE The aim of this study was to determine the effects of an 8-week program of resistance training (RT) or suspension training (ST) on explosive strength in prepubescent boys. METHODS Fifty-seven boys aged 10-11 years were assigned to 2 training groups, RT or ST or a control group (no training program). Boys trained twice weekly for 8 weeks. RESULTS A significant interaction was reported with a large (P < .001, ηp2=.463), medium (P < .001, ηp2=.395), and small effect sized (P ≤ .001, ηp2=.218) in the 1-kg ball throw, 3-kg ball throw, and time-at-20-m test, respectively. There was no significant interaction in the countermovement vertical jump or the standing long jump. Changes from preintervention to postintervention for the 1-kg ball throw were 5.94% and 5.82% for the ST and RT, respectively, and 8.82% and 8.14% in the 3-kg ball throw for the ST and RT, respectively. The improvement in the 20-m sprint was 1.19% for the ST and 2.33% for the RT. CONCLUSION Traditional RT and ST seem to be effective methods for improving explosive strength in prepubescent boys. ST could be considered as an alternative modality to optimize explosive strength training in school-based programs.
Hits and Holds: Two Algorithms for Identifying the Elephant Flows

As networks expanded largely and link speeds grow rapidly,keeping a counter for each flow is too expensive.Estan et al.propose two algorithms: sample and hold and multistage filters,to identify large flows,which have obvious shortcomings: sample and hold discard packets randomly while multistage filters simultaneously calculate 5~6 hash functions that is unsuitable for hardware implementation.This paper proposes two algorithms,Hits and Holds,to identify large flows quickly and correctly,which overcome the shortcomings of Estan’s algorithms,while effectively reducing false positive and false negative errors.
Intravesical Chemotherapy after Radical Nephroureterectomy for Primary Upper Tract Urothelial Carcinoma: A Systematic Review and Network Meta-Analysis

The aim of this study was to determine the prophylactic effect of intravesical chemotherapy. Furthermore, it aimed to compare the efficacy of regimens on the prevention of bladder recurrence, after nephroureterectomy, for upper tract urothelial carcinoma by systematic review and network meta-analysis. A comprehensive literature search was conducted to search for studies published before 22 December 2016 using PubMed, Embase, and Scopus. All studies comparing nephroureterectomy alone with prophylactic intravesical chemotherapy after nephroureterectomy were included. The primary outcome was intravesical recurrence-free survival rate. In addition, we conducted indirect comparisons among regimens using network meta-analysis, as well as three randomized controlled trials (RCTs) on multicenter setting, and one large retrospective study with a total of 532 patients were analyzed. The pooled hazard ratio (HR) of bladder recurrence was 0.54 (95% CI: 0.38–0.76) in intravesical instillation patients. On network meta-analysis, pirarubicin was ranked the most effective regimen, while maintenance therapy of mitomycin C (MMC) with Ara-C and induction therapy of MMC were ranked as the second and third most effective regimens, respectively. Our study demonstrates that intravesical chemotherapy can prevent bladder recurrence in patients with upper tract urothelial carcinoma after nephroureterectomy. It also suggests that a single instillation of pirarubicin is the most efficacious intravesical regimen.
A Mediterranean Diet Rich in Extra-Virgin Olive Oil Is Associated with a Reduced Prevalence of Nonalcoholic Fatty Liver Disease in Older Individuals at High Cardiovascular Risk.

BACKGROUND Adherence to a Mediterranean diet (MedDiet) is thought to reduce liver steatosis. OBJECTIVES To explore the associations with liver steatosis of 3 different diets: a MedDiet + extra-virgin olive oil (EVOO), MedDiet + nuts, or a control diet. METHODS This was a subgroup analysis nested within a multicenter, randomized, parallel-group clinical trial, PREvención con DIeta MEDiterránea (PREDIMED trial: ISRCTN35739639), aimed at assessing the effect of a MedDiet on the primary prevention of cardiovascular disease. One hundred men and women (mean age: 64 ± 6 y), at high cardiovascular risk (62% with type 2 diabetes) from the Bellvitge-PREDIMED center were randomly assigned to a MedDiet supplemented with EVOO, a MedDiet supplemented with mixed nuts, or a control diet (advice to reduce all dietary fat). No recommendations to lose weight or increase physical activity were given. Main measurements were the percentage of liver fat and the diagnosis of steatosis, which were determined by NMR imaging. The association of diet with liver fat content was analyzed by bivariate analysis after a median follow-up of 3 y. RESULTS Baseline adiposity and cardiometabolic risk factors were similar among the 3 treatment arms. At 3 y after the intervention hepatic steatosis was present in 3 (8.8%), 12 (33.3%), and 10 (33.3%) of the participants in the MedDiet + EVOO, MedDiet + nuts, and control diet groups, respectively (P = 0.027). Respective mean values of liver fat content were 1.2%, 2.7%, and 4.1% (P = 0.07). A tendency toward significance was observed for the MedDiet + EVOO group compared with the control group. Median values of urinary 12(S)-hydroxyeicosatetraenoic acid/creatinine concentrations were significantly (P = 0.001) lower in the MedDiet + EVOO (2.3 ng/mg) than in the MedDiet + nuts (5.0 ng/mg) and control (3.9 ng/mg) groups. No differences in adiposity or glycemic control changes were seen between groups. CONCLUSIONS An energy-unrestricted MedDiet supplemented with EVOO, a food with potent antioxidant and anti-inflammatory properties, is associated with a reduced prevalence of hepatic steatosis in older individuals at high cardiovascular risk.
Plant defenses interact with insect enteric bacteria by initiating a leaky gut syndrome

Significance Many plant defenses that deter insect herbivory target the attacker’s digestive system. We found that plant defenses against the fall armyworm created opportunities for resident gut microbes to penetrate protective gut barriers, invading the body cavity and exacerbating the negative impacts of plant defenses on the insect. These interactions triggered insect immune responses and collectively overwhelmed the insect’s ability to cope with multiple stressors. However, the effects varied between bacterial taxa, indicating that variation in the caterpillar microbiome can alter their phenotype. Our results reveal a previously unrecognized, and likely widespread, mechanism allowing the plant to use the insect’s gut microbiota against it in collaboration with the plant’s own defenses. Plants produce suites of defenses that can collectively deter and reduce herbivory. Many defenses target the insect digestive system, with some altering the protective peritrophic matrix (PM) and causing increased permeability. The PM is responsible for multiple digestive functions, including reducing infections from potential pathogenic microbes. In our study, we developed axenic and gnotobiotic methods for fall armyworm (Spodoptera frugiperda) and tested how particular members present in the gut community influence interactions with plant defenses that can alter PM permeability. We observed interactions between gut bacteria with plant resistance. Axenic insects grew more but displayed lower immune-based responses compared with those possessing Enterococcus, Klebsiella, and Enterobacter isolates from field-collected larvae. While gut bacteria reduced performance of larvae fed on plants, none of the isolates produced mortality when injected directly into the hemocoel. Our results strongly suggest that plant physical and chemical defenses not only act directly upon the insect, but also have some interplay with the herbivore’s microbiome. Combined direct and indirect, microbe-mediated assaults by maize defenses on the fall armyworm on the insect digestive and immune system reduced growth and elevated mortality in these insects. These results imply that plant–insect interactions should be considered in the context of potential mediation by the insect gut microbiome.
Leader-Based Multi-Scale Attention Deep Architecture for Person Re-Identification

Person re-identification (re-id) aims to match people across non-overlapping camera views in a public space. This is a challenging problem because the people captured in surveillance videos often wear similar clothing. Consequently, the differences in their appearance are typically subtle and only detectable at particular locations and scales. In this paper, we propose a deep re-id network (MuDeep) that is composed of two novel types of layers – a multi-scale deep learning layer, and a leader-based attention learning layer. Specifically, the former learns deep discriminative feature representations at different scales, while the latter utilizes the information from multiple scales to lead and determine the optimal weightings for each scale. The importance of different spatial locations for extracting discriminative features is learned explicitly via our leader-based attention learning layer. Extensive experiments are carried out to demonstrate that the proposed MuDeep outperforms the state-of-the-art on a number of benchmarks and has a better generalization ability under a domain generalization setting.
Std fimbriae-fucose interaction increases Salmonella-induced intestinal inflammation and prolongs colonization

Expression of ABO and Lewis histo-blood group antigens by the gastrointestinal epithelium is governed by an α-1,2-fucosyltransferase enzyme encoded by the Fut2 gene. Alterations in mucin glycosylation have been associated with susceptibility to various bacterial and viral infections. Salmonella enterica serovar Typhimurium is a food-borne pathogen and a major cause of gastroenteritis. In order to determine the role of Fut2-dependent glycans in Salmonella-triggered intestinal inflammation, Fut2+/+ and Fut2-/- mice were orally infected with S. Typhimurium and bacterial colonization and intestinal inflammation were analyzed. Bacterial load in the intestine of Fut2-/- mice was significantly lower compared to Fut2+/+ mice. Analysis of histopathological changes revealed significantly lower levels of intestinal inflammation in Fut2-/- mice compared to Fut2+/+ mice and measurement of lipocalin-2 level in feces corroborated histopathological findings. Salmonella express fimbriae that assist in adherence of bacteria to host cells thereby facilitating their invasion. The std fimbrial operon of S. Typhimurium encodes the π-class Std fimbriae which bind terminal α(1,2)-fucose residues. An isogenic mutant of S. Typhimurium lacking Std fimbriae colonized Fut2+/+ and Fut2-/- mice to similar levels and resulted in similar intestinal inflammation. In vitro adhesion assays revealed that bacteria possessing Std fimbriae adhered significantly more to fucosylated cell lines or primary epithelial cells in comparison to cells lacking α(1,2)-fucose. Overall, these results indicate that Salmonella-triggered intestinal inflammation and colonization are dependent on Std-fucose interaction.
Prader-Willi Syndrome - Clinical Genetics, Diagnosis and Treatment Approaches: An Update

Background Prader-Willi Syndrome (PWS) is a neurodevelopmental genomic imprinting disorder with lack of expression of genes inherited from the paternal chromosome 15q11-q13 region usually from paternal 15q11-q13 deletions (about 60%) or maternal uniparental disomy 15 or both 15s from the mother (about 35%). An imprinting center controls the expression of imprinted genes in the chromosome 15q11-q13 region. Key findings include infantile hypotonia, a poor suck, failure to thrive and hypogonadism/hypogenitalism. Short stature and small hands/feet due to growth and other hormone deficiencies, hyperphagia and marked obesity occur in early childhood, if uncontrolled. Cognitive and behavioral problems (tantrums, compulsions, compulsive skin picking) are common. Objective Hyperphagia and obesity with related complications are major causes of morbidity and mortality in PWS. This report will describe an accurate diagnosis with determination of specific genetic subtypes, appropriate medical management and best practice treatment approaches. Methods and Results An extensive literature review was undertaken related to genetics, clinical findings and laboratory testing, clinical and behavioral assessments and summary of updated health-related information addressing the importance of early PWS diagnosis and treatment. A searchable, bulleted and formatted list of topics is provided utilizing a Table of Contents approach for the clinical practitioner. Conclusion Physicians and other health care providers can use this review with clinical, genetic and treatment summaries divided into sections pertinent in the context of clinical practice. Frequently asked questions by clinicians, families and other interested participants or providers will be addressed.
Meditation interventions among heart failure patients: An integrative review

Background: There has been growing interest in meditation techniques as an intervention in chronic disease populations. Little is known of the effect meditation practice has on outcomes among patients with heart failure. Purpose: To identify and examine current literature on meditation interventions on heart failure outcomes. Method: The review utilized methods described by Whittemore and Knafl. Three electronic databases were searched through March 2018. Terms used were “mindfulness OR meditation” and “heart failure” in combination, generating 58 articles after duplicates were removed. After inclusion and exclusion criteria were applied, six studies qualified for review, including four articles with samples from the United States and two with samples from Brazil and Sweden, respectively. Results: Among the six studies in the final sample, the total number of participants was 320 heart failure patients. Interventional design and length varied among the studies, and 20 different dependent variables were identified. This study distinguished four categories of outcome measures with significant findings: psychosocial, biophysical, quality of life and heart failure symptom burden. Compared with controls meditation practice significantly improved depression (p<.05), social support (p<.05), biophysical factors and quality of life (p<.05), in addition to reducing heart failure symptom burden. Across-study comparisons were limited due to variation in intervention definitions and designs. Additionally, the intervention dose and reporting method varied, limiting comparisons. The sample size in five out of six studies was fewer than 50 participants. Over 20 different measures were used across the six studies to measure outcome variables. Conclusion: Meditation may offer a patient-driven practice to reduce heart failure symptoms as well as improve psychosocial wellness and quality of life. Future research among heart failure patients should include the following: rigorous definition of meditation interventions, consistency in intervention characteristics, larger controlled trials, and standardized outcome instruments.
Conductance-based biophysical distinction and microfluidic enrichment of nano-vesicles derived from pancreatic tumor cells of varying invasiveness.

Diagnostics based on exosomes and other extracellular vesicles (EVs) are emerging as strategies for informing cancer progression and therapies, since the lipid content and macromolecular cargo of EVs can provide key phenotypic and genotypic information on the parent tumor cell and its microenvironment. We show that EVs derived from more invasive pancreatic tumor cells, which express high levels of tumor-specific surface proteins and are composed of highly unsaturated lipids that increase membrane fluidity, exhibit significantly higher surface conductance, as measured by dielectrophoresis, in comparison to those derived from less invasive tumor cells. Furthermore, through specific binding of the EVs to gold nanoparticle-conjugated antibodies, we show that these conductance differences can be modulated in proportion to the type, as well as level of expressed tumor-specific antigens, thereby presenting methods for selective microfluidic enrichment and cytometry-based quantification of EVs based on invasiveness of their parent cell.