Miracle-dz/UniFAR-FTUs huggingface dataset:
Network Based Caching for Near Real-Time Streaming Video

Nowadays more and more live events are being consumed via the web or smart phones rather than legacy broadcast services. In this paper we present a scenario − focusing on wireless smartphone-based nodes − that covers this trend. Starting from this scenario we introduce a novel service that can be offered on top of classical streaming media services to the users of these mobile handheld devices. Considering that the wireless infrastructure is heavily loaded by the traffic of the real-time stream itself, we propose a distributed caching solution to offload it, improving the scalability of the system. We define two heuristic algorithms to place the caching elements within the network in an optimal way – the goal was either to minimize the required number of caching nodes or the size of the cache. In our earlier work we have investigated some individual aspects covered by the scenario and built a testbed that implements these proposals. In this paper we present the extension of this integrated testbed suitable for network coding based communication, which supports the measurement based evaluation of the presented scenario and the evaluation of the implementation details. Finally we offer a measurement based assessment of the features implemented in the testbed.
Intussusception following treatment for glioblastoma multiforme: A rare association

Sir, Non-Hodgkins Lymphoma (NHL) as a lead point causing intussusception is very rare, though reported. [1] Our patient was a 6-year-old boy who was symptomatic for three months with a vague, ill-defined pain in the right lower abdomen with recurrent episodes of bilious vomiting. Two years ago, he had been diagnosed with Glioblastoma Multiforme grade IV, for which he had undergone craniotomy and tumor excision, followed by radiotherapy and chemotherapy with temozolomide (TMZ). Abdominal examination revealed a solitary globular, soft, nontender ill-defined fixed mass measuring about 5 × 5 cm in the right iliac fossa. Ultrasound revealed hypoechoic thick-walled concentric ring-like lesion in the right hypochondrium with vascularity in the region. Barium meal follow through was suggestive of chronic ileocolic intussusception [Figure 1]. The patient underwent laparotomy and, intraoperatively, a 2 × 2–cm intraluminal mass was noticed in the cecum with edematous terminal ileum and multiple mesenteric lymph nodes. A limited right hemicolectomy with ileo ascending end-to-end anastomosis was performed. Postoperative recovery was unremarkable. The histopathology of the resected cecal polyp revealed NHL, B cell immunophenotype with CD 20 positivity. The dissected lymph nodes also showed the features of NHL. The patient has been started on a chemotherapy regime for NHL.
Opstrukcijska apneja u snu – važan čimbenik srčanožilnog rizika

Rijec je o prekidu disanja tijekom sna do kojeg dolazi zbog kolapsa faringealne muskulature. Opstrukcijska apneja podrazumijeva prestanak disanja u trajanju od deset ili vise sekunda, uz istovremene kontrakcije disne muskulature.1 O opstrukcijskoj hipopneji govori se kad je ventilacija smanjena (odnosno, nepotpuno prekinu­ ta), povezana s padom saturacije kisika ili s buđenjem. Dijagnoza opstrukcijske apneje u snu postavlja se kad je apneja­hipopneja indeks (AHI) u satu veci od pet, uz izrazitu pospanost tijekom dana. Kolaps misica ždrijela u bolesnika s OAS­om za­ hvaca stražnji dio jezika, uvulu, meko nepce, odnosno one organe koji inace nemaju kostanu ili neku cvrscu potporu, te su zbog toga, izrazito ovisni o tonusu u održavanju prohodnosti tog dijela disnog puta.2 Dakle, temeljni, primarni poremecaj u bolesnika s OAS­om anatomsko je suženje nastalo kao posljedica uskog fa­ ringealnog dijela disnog puta, kao posljedica debljine, kostanih ili mekotkivnih promjena, povecanih tonzila ili adenoidnih vegetacija (npr. u djece) (slika 1). Tijekom apneje ili hipopneje, hipoksija i hiperkapnija stimuliraju ventilacijske napore (disne muskulaturte) ili pak iza­ zivaju buđenje da bi se prekinula hipoksicna epizoda. Apneja i hipopneja mogu biti ne samo opstrukcijske vec i tzv. centralne, gdje uz prestanak disanja, izostaju kontrakcije disne muskulature.
Smoking reduction with oral nicotine inhalers: double blind, randomised clinical trial of efficacy and safety

Abstract Objectives: To determine whether use of an oral nicotine inhaler can result in long term reduction in smoking and whether concomitant use of nicotine replacement and smoking is safe. Design: Double blind, randomised, placebo controlled trial. Four month trial with a two year follow up. Setting: Two university hospital pulmonary clinics in Switzerland. Participants: 400 healthy volunteers, recruited through newspaper advertisements, willing to reduce their smoking but unable or unwilling to stop smoking immediately. Intervention: Active or placebo inhaler as needed for up to 18 months, with participants encouraged to limit their smoking as much as possible. Main outcome measures: Number of cigarettes smoked per day from week six to end point. Decrease verified by a measurement of exhaled carbon monoxide at each time point compared with measurement at baseline. Results: At four months sustained reduction of smoking was achieved in 52 (26%) participants in the active group and 18 (9%) in the placebo group (P<0.001; Fisher's test). Corresponding figures after two years were 19 (9.5%) and 6 (3.0%) (P=0.012). Conclusion: Nicotine inhalers effectively and safely achieved sustained reduction in smoking over 24 months. Reduction with or without nicotine substitution may be a feasible first step towards smoking cessation in people not able or not willing to stop abruptly.
The temperature-mass relation in magnetized galaxy clusters

We use cosmological, magneto-hydrodynamic simulations of galaxy clusters to quantify the dynamical importance of magnetic elds in these clusters. The set-up of initial magnetic eld strengths at high redshifts is chosen such that observed Faraday-rotation measurements in low-redshift clusters are well reproduced in the simulations. We compute the radial proles of the intracluster gas temperature and of the thermal and magnetic pressure in a set of clusters simulated in the framework of an Einstein-de Sitter and a low-density, spatially-flat CDM cosmological model. We nd that, for a realistic range of initial magnetic eld strengths, the temperature of the intracluster gas changes by less than5%
Regularized Image Reconstruction from Projections Method

We propose a new image reconstruction from projection method consistent with the maximum a posteriori probability (MAP) approach, i.e. using regularization. We compare reconstruction with three regularization methods -- Tikhonov regularization, smoothed total variation regularization, and early stopping. We compute a number of objective evaluation measures and compare the reconstruction results. We conclude that the best result, both in terms of subjective and objective assessment, is obtained for smoothed total variation regularization.
Environmentally toxicant exposures induced intragenerational transmission of liver abnormalities in mice

Environmental toxicants such as chemicals, heavy metals, and pesticides have been shown to promote transgenerational inheritance of abnormal phenotypes and/or diseases to multiple subsequent generations following parental and/or ancestral exposures. This study was designed to examine the potential transgenerational action of the environmental toxicant trichloroethane (TCE) on transmission of liver abnormality, and to elucidate the molecular etiology of hepatocyte cell damage. A total of thirty two healthy immature female albino mice were randomly divided into three equal groups as follows: a sham group, which did not receive any treatment; a vehicle group, which received corn oil alone, and TCE treated group (3 weeks, 100 μg/kg i.p., every 4th day). The F0 and F1 generation control and TCE populations were sacrificed at the age of four months, and various abnormalities histpathologically investigated. Cell death and oxidative stress indices were also measured. The present study provides experimental evidence for the inheritance of environmentally induced liver abnormalities in mice. The results of this study show that exposure to the TCE promoted adult onset liver abnormalities in F0 female mice as well as unexposed F1 generation offspring. It is the first study to report a transgenerational liver abnormalities in the F1 generation mice through maternal line prior to gestation. This finding was based on careful evaluation of liver histopathological abnormalities, apoptosis of hepatocytes, and measurements of oxidative stress biomarkers (lipid peroxidation, protein carbonylation, and nitric oxide) in control and TCE populations. There was an increase in liver histopathological abnormalities, cell death, and oxidative lipid damage in F0 and F1 hepatic tissues of TCE treated group. In conclusion, this study showed that the biological and health impacts of environmental toxicant TCE do not end in maternal adults, but are passed on to offspring generations. Hence, linking observed liver abnormality in the offspring to environmental exposure of their parental line. This study also illustrated that oxidative stress and apoptosis appear to be a molecular component of the hepatocyte cell injury.
Effect of Biofilm Growth on Expression of Surface Proteins of Actinomyces naeslundii Genospecies 2

ABSTRACT The predominant surface proteins of biofilm and planktonic Actinomyces naeslundii, a primary colonizer of the tooth surface, were examined. Seventy-nine proteins (the products of 52 genes) were identified in biofilm cells, and 30 of these, including adhesins, chaperones, and stress-response proteins, were significantly up-regulated relative to planktonic cells.
Thermodynamic properties and pressure effect on the superconductivity in CaAlSi and SrAlSi

Superconductivity in the $C32$ compounds CaAlSi and SrAlSi is investigated by heat capacity measurements as well as high-pressure ac-susceptibility experiments. The heat capacity in the superconducting state is well explained by the BCS theory for weak (SrAlSi) and enhanced coupling strength (CaAlSi). The magnitudes of the superconducting gaps are estimated as 2.7 meV (CaAlSi) and 1.4 meV (SrAlSi). The pressure effect on the superconducting transition temperature, $d\mathrm{ln}{T}_{c}/dp,$ is positive in CaAlSi $(+0.026{\mathrm{GPa}}^{\ensuremath{-}1})$ but negative in SrAlSi $(\ensuremath{-}0.024{\mathrm{GPa}}^{\ensuremath{-}1}). $ The opposite sign of the pressure coefficients of ${T}_{c}$ indicates distinct differences in the electronic structure and the density of states at the Fermi energy of the two compounds in agreement with recent band structure calculations.
Diabetes-Related Autoantibodies in Children With Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is the most common subtype of leukemia in children. Although ALL and type 1 diabetes appear to be biologically unrelated, there are common threads in both epidemiology and etiology. Rising incidence rates of both ALL (1) and type 1 diabetes (2) observed over recent decades in many Western countries seem to support common etiological factors (3). In the current study, we report on diabetes-related autoantibodies (Abs) in a group of patients with ALL. Thirty-four consecutive children (19 males and 15 females, mean age 6.2 ± 4.6 years) were referred to our institution in 2004 for newly diagnosed ALL. Patients were tested for Abs to islet and thyroid antigens. After the initial investigation and treatment, 31/34 (91%) patients (3 died in the mean time) were followedup for 6 years to evaluate the evolution of the autoimmune markers and progression toward type 1 diabetes. Glutamic acid decarboxylase (GAD) Abs by direct …
E-Business's Page Ranking with Ant Colony Algorithm

Almost all E-Business transactions use classical keyword-based methods for searching commercial goods. One of the main problems that plague modern search engines is poor relevance. In many situations, search engines retrieve thousands of pages at least partially satisfying input query. Of course, human attention remains more or less constant, and most humans are able to cope only with about 100-200 retrieved documents. PageRank index method has been successfully used for search engine output sorting. Two such experimental search engines have been constructed at Stanford University [1]. There seems to be quite high correlation between high PageRank index, and general page importance judged by human users. This is especially spectacular for very general queries, for which a lot of relevant pages exist in the Internet. This work proposes an algorithm for page rank called Ant Colony Ranking (ACR) algorithm. The goal of this paper is to investigate the Ant Colony Ranking (ACR) algorithm in the context of such selfmodifying systems to solve two drawbacks of this method. The experiments show that the algorithm has good convergence properties over hypertext structure of the Internet.
Immune reconstitution after transplantation of autologous peripheral CD34+ cells: analysis of predictive factors and comparison with unselected progenitor transplants

The recovery of lymphocyte count, CD4+ and CD8+ T‐cell subsets, natural killer (NK) cells and CD19+ B‐cells was evaluated in a cohort of 15 patients receiving autologous CD34+ peripheral blood progenitor cells (PBPCs; group A) for haematological malignancies and in 20 patients transplanted with autologous unselected PBPCs (group B). Lymphocyte count recovered in both patient cohorts, being significantly lower in group A than in group B 1 (P = 0·008) and 2 months (P = 0·0035) after progenitor cell infusion. The repopulation of CD3+ T‐cells occurred more rapidly in group B than in group A (P = 0·034 on week 4); CD19+ B‐lymphocytes did not return to reference ranges in either group of patients. The count of CD4+ T‐lymphocytes remained < 200/μl during the study period in patients transplanted with CD34+ PBPCs, significantly lower than group B levels (P = 0·034 and P = 0·021 on weeks 4 and 8 respectively). CD8+ T‐cells increased rapidly in both groups; thus, the CD4 to CD8 ratio was severely reduced. CD4+ and CD8+ T‐cells displayed an activated phenotype in both groups of patients, co‐expressing the HLA‐DR antigen throughout the study period. NK cells followed a similar repopulation kinetics in both study groups, although their expansion was greater in group B than in group A (P = 0·014 on week 4). In the CD34+ group, post‐transplant administration of granulocyte colony‐stimulating factor predicted a faster lymphocyte recovery in multivariate analysis (P = 0·025); interestingly, the amount of passively transferred lymphocytes correlated inversely with time to achieve a lymphocyte count > 0·5 × 109/l (r = –0·63, P = 0·01). Further investigations are necessary to characterize T‐cell competence after transplantation of CD34+ PBPCs.
Logics in access control: a conditional approach

The paper introduces a framework based on constructive conditional logics to define axiomatization, semantics and proof methods for access control logics. We formalize the well known says operator as a conditional normal modality and, by considering some specific combinations of access control axioms, we define four access control logics, namely, CondUC ACL , Cond U4 ACL , CondIC ACL and Cond I4 ACL . Such logics integrate access control logics with intuitionistic conditional logics and provide a natural formulation of boolean principals. The well known “speaks for” operator introduced in the logic ABLP is defined on the top of the says modality. We provide a Kripke model semantics for the logics and we prove that their axiomatization is sound and complete with respect to the semantics. Also, we develop sound, complete, cut-free sequent calculi for them. For the logic CondUC ACL , which (as concerns atomic principals) is slightly stronger than the logic ICL recently introduced by Garg and Abadi, we also provide a terminating sequent calculus, thus proving that the logic is decidable and that validity in CondUC ACL is in PSPACE.
Assessing the quality of the management skills required for lower respiratory tract infections in Kilimanjaro, Tanzania

Background: Lower respiratory tract infections (LRTI) are among the leading causes of morbidity and mortality. A severe form of atypical pneumonia, Q fever, has been found in Northern Tanzania. Assessment of the quality of health care for lower respiratory tract infection from the clinicians’ performance has rarely been performed. Methods: A cross sectional descriptive study using the qualitative and quantitative approaches for assessing clinicians and patient files from 11 health facilities of Kilimanjaro region. The facilities were of 4 different levels of public health care delivery and 1 private independent hospital. Results: Medications for LRTI were highly variable in 346 files and from attempts of treatment reported in 53 clinician’s interviews. No file showed attempts for assessing the severity of Pneumonia. Only 6 (11.1%) clinicians could mention causes of atypical pneumonia. Only 7 clinicians (13.0%) were aware of Q-fever and could mention the cause. The quality of clinical records for monitoring the progress was not the same in all levels of care and the difference in availability was statistically significant as level of mental state χ2 (4) = 139.4; P value
Somatostatin augments the spread of limbic seizures from the hippocampus

The role of the neuropeptide somatostatin in limbic seizures was studied using electrical stimulation of the hippocampus in kindled rats. Cysteamine, an agent which selectively and reversibly depletes brain somatostatin stores, had a biphasic action. An early proconvulsant effect was seen within a few hours, consisting of prolonged electrographic seizures in the hippocampus and more severe behavioral convulsions. A later anticonvulsant effect, maximal at 1 to 2 days and dissipating within a week, was manifested by less intense behavioral convulsions without change in the duration of electrical seizure activity. Both effects were dose‐dependent. No change in afterdischarge thresholds was detected at any time after the administration of cysteamine. Intraventricular administration of somatostatin to animals with behavioral seizures attenuated by cysteamine treatment restored the responses to precysteamine levels. We conclude that somatostatin facilitates the spread of seizures over limbic circuits from a region of focal seizure initiation.
Using principal components to test normality of high-dimensional data

ABSTRACT Many multivariate statistical procedures are based on the assumption of normality and different approaches have been proposed for testing this assumption. The vast majority of these tests, however, are exclusively designed for cases when the sample size n is larger than the dimension of the variable p, and the null distributions of their test statistics are usually derived under the asymptotic case when p is fixed and n increases. In this article, a test that utilizes principal components to test for nonnormality is proposed for cases when p/n → c. The power and size of the test are examined through Monte Carlo simulations, and it is argued that the test remains well behaved and consistent against most nonnormal distributions under this type of asymptotics.
Attenuated response to purified protein derivative in patients with rheumatoid arthritis: study in a population with a high prevalence of tuberculosis

Background: The purified protein derivative (PPD) skin test is the only widely used method which detects latent tuberculosis infection (LTBI) and is dependent on a normal T cell function. In rheumatoid arthritis (RA) the T cell function is altered, which may result in an inability to develop an adequate PPD reaction. Objectives: To evaluate the response to PPD in patients with RA and to compare it with that of control subjects. Methods: 112 patients with RA and 96 healthy controls were studied. PPD 5 U was applied using the Mantoux method, and skin reaction was measured at 72 hours. The reaction was considered negative for PPD <5 mm. Results: There were no significant differences in age, sex, history of bacille Calmette-Guerin vaccination, or tuberculosis contact between the two groups. The median size of the PPD induration in the patients with RA was significantly less than that in the control group (4.5 v 11.5 mm, p<0.01). 79 (70.6%) patients with RA compared with 25 (26%) of the control group had a negative reaction to PPD (p<0.01), a response not influenced by disease activity or duration of disease in the patients with RA. Conclusion: A PPD skin test is not an appropriate test for recognising LTBI in patients with RA in our population.
Bench-to-bedside: The use of local anesthetics to attenuate inflammation in acute respiratory distress syndrome

The acute respiratory distress syndrome (ARDS) remains a world-wide treatment challenge, with high morbidity and mortality. The central pathophysiology of ARDS centers around inflammation in the lung and increased microvascular permeability. Local anesthetics have been shown to have anti-inflammatory effects at the basic science level and the advent of local anesthetics with improved cardiovascular safety profiles has made use of local anesthetics in attenuating the inflammation in ARDS a recent research interest. In this review, we will provide a brief summary of some of the basic science work in local anesthetics and lung inflammation and provide a case for the bench to bedside research in this potential therapy.
TRP-ML1 Regulates Lysosomal pH and Acidic Lysosomal Lipid Hydrolytic Activity*

Mucolipidosis type IV (MLIV) is caused by mutations in the ion channel mucolipin 1 (TRP-ML1). MLIV is typified by accumulation of lipids and membranous materials in intracellular organelles, which was hypothesized to be caused by the altered membrane fusion and fission events. How mutations in TRP-ML1 lead to aberrant lipolysis is not known. Here we present evidence that MLIV is a metabolic disorder that is not associated with aberrant membrane fusion/fission events. Thus, measurement of lysosomal pH revealed that the lysosomes in TRP-ML1-/- cells obtained from the patients with MLIV are over-acidified. TRP-ML1 can function as a H+ channel, and the increased lysosomal acidification in TRP-ML1-/- cells is likely caused by the loss of TRP-ML1-mediated H+ leak. Measurement of lipase activity using several substrates revealed a marked reduction in lipid hydrolysis in TRP-ML1-/- cells, which was rescued by the expression of TRP-ML1. Cell fractionation indicated specific loss of acidic lipase activity in TRP-ML1-/- cells. Furthermore, dissipation of the acidic lysosomal pH of TRP-ML1-/- cells by nigericin or chloroquine reversed the lysosomal storage disease phenotype. These findings provide a new mechanism to account for the pathogenesis of MLIV.
Les Facultés de lettres doivent-elles assurer l'employabilité de leurs diplômés ?

Introduction relative au concept de l'employabilite, Resultats d'enquetes sur le devenir professionnel des diplomes de la Faculte de philosophie, arts et lettres de l'Universite catholique de Louvain et pistes a envisager afin de mieux assurer l'employabilite des diplomes.