Miracle-dz/UniFAR-FTUs huggingface dataset:
New Road Transport Infrastructure and Sectoral Regional Growth: A SCGE Analysis for the A4 extension to the Austrian- Hungarian border

In mature economies new transport infrastructure (beyond bottle-neck elimination) is considered to hardly influence overall growth, but well so its spatial distribution and implied transport emissions. In a sectorally diversified spatial computable general equilibrium (SCGE) model of the Lower Austrian - Burgenland new highway (opened in 1991) to the now new member state Hungary, we analyse regional growth. Based on a GIS-approach we acknowledge both actual freight transport cost reduction by sector and interregional link and labour force accessibility change. We find that freight transport cost reduction even for a small region does have negligible overall economic impacts. However, it is a few transport intensive sectors that show substantial impact in interregional trading prices and regional output. In particular our findings point out, that locally specific sectoral shares in production, freight transport cost shares, and - most of all - accessibility determine the order of magnitude of regional economic impact and transport emission consequences.
PREPARATION OF MYCOPLASMA SYNOVIAE ANTIGENS AND EVALUATION BY RAPID SLIDE AGGLUTINATION AND ENZYME LINKED IMMUNOSORBENT ASSAY

Poultry industry has high annual growth rate in Pakistan. Mycoplasmosis, separately or in combination with other diseases, cause major setbacks to poultry industry. Due to significant role of Mycoplasmosis in poultry industry, its control programme success depends on timely and accurate diagnosis of infected flocks. Poultry flocks are generally screened for Mycoplasma by Rapid Slide Agglutination (RSA) test and Enzyme Linked Immunosorbent Assay. Aim of the current project was to prepare and evaluate indigenous Mycoplasma synoviae RSA antigen and ELISA plate coating antigen. M. Synoviae isolates were characterized using 16s rRNA polymerase chain reaction. RSA antigen was prepared using Rose Bengal dye and compared with a commercially prepared RSA antigen. Incubation of ELISA plate, coated with indigenous antigen, at 4C and 37C had no significant difference (P=1.0000), but there was a significant difference (P value = 0.01) in the ELISA antibody titers of plates, coated with local antigen incubated at 37C compared with pre coated plates available in imported kit. ELISA plate coating antigen and RSA antigen of M. synoviae prepared from local isolate is cheap and produced equally reliable results to their commercial companion.
Factors Affecting Employee Performance: A Conceptual Study on the Drivers of Employee Engagement

Employee Engagement, as a concept, has been gaining significance since the past 10 years. Organizations today consider engaged employees as strategic partners in their businesses. The concept of employee engagement has now gained even more prominence, since many drivers have been identified, which impact employee performance and well-being at the workplace. As companies across industries strive to survive and rise above the stiff competition, physical and mental well-being of employees will be one of the important aspects that HR managers need to focus on. Hence, employee engagement is today seen as a powerful source of competitive advantage, especially in the turbulent times. The present study explored the concept of employee engagement and also throws light on key drivers of employee engagement by analyzing specifically four drivers, namely communication, work-life balance, leadership, and organizational culture. Furthermore, this study also analyzed how these drivers impacted the level of employee performance and well-being at the workplace. The existing literature on drivers of employee engagement indicated that there is paucity of research on these four drivers and their impact on employee engagement. Thus, we focused on these four specific and less researched drivers.
Tumor and Stromal-Based Contributions to Head and Neck Squamous Cell Carcinoma Invasion

Head and neck squamous cell carcinoma (HNSCC) is typically diagnosed at advanced stages with evident loco-regional and/or distal metastases. The prevalence of metastatic lesions directly correlates with poor patient outcome, resulting in high patient mortality rates following metastatic development. The progression to metastatic disease requires changes not only in the carcinoma cells, but also in the surrounding stromal cells and tumor microenvironment. Within the microenvironment, acellular contributions from the surrounding extracellular matrix, along with contributions from various infiltrating immune cells, tumor associated fibroblasts, and endothelial cells facilitate the spread of tumor cells from the primary site to the rest of the body. Thus far, most attempts to limit metastatic spread through therapeutic intervention have failed to show patient benefit in clinic trails. The goal of this review is highlight the complexity of invasion-promoting interactions in the HNSCC tumor microenvironment, focusing on contributions from tumor and stromal cells in order to assist future therapeutic development and patient treatment.
Stock Market Liquidity and Optimal Management Compensation: Theory and Evidence

Recent research strongly suggests that CEO incentive schemes are not solely determined by the standard considerations of risk-sharing and effort. Here, we examine the effect of the microstructure of the market in which the firm's shares are traded. If informed traders are free to choose both the size of orders they place on the market and the amount of information they gather, an increase in market liquidity makes the stock price more informative and increases the optimal linkage between CEO compensation and shareholder wealth. If on the other hand informed traders are severely restricted in their ability to take positions by considerations such as wealth constraints, increased liquidity reduces the informativeness of share price and dilutes optimal CEO incentives. We find evidence to support the second view in a sample of 329 large US corporations. Our sample contains firms that are listed on either the NYSE or the NASDAQ. The relationship between CEO incentives and the spread is significant and positive only for the NYSE firms, and NYSE firms have significantly higher pay-performance sensitivities. These results suggest a regulatory explanation whereby the monopoly specialist on the NYSE widens the bid-ask spread on small trades and subsidizes more informative large trades because of an affirmative duty to dampen large price movements.
Identification of Apoptotic Cells by Means of Lectin Histochemistry: State of the Art Review

Apoptosis is a cellular phenomenon of great importance in the cellular homeostasis of tissues and organs. For many years diverse techniques have been developed for the identification and differentiation of normal and apoptotic cells, but only in cells isolated in cultures as in histology sections. These techniques are based on the modifications that cells suffer during the process of apoptosis. One of these changes is linked with modifications of glycoconjugates in the glycocalix of cells, which allows the use of lectins for identification of these apoptotic cells. In this review, we first present the data obtained to date with this approach for the detection of apoptotic cells with lectins, both using flow cytometry and, especially, cytochemical methods. Secondly we comment on the results obtained in the detection of apoptotic cells with classical lectin histochemistry using histological sections of the seminiferous epithelium. These results open the possibility of using lectins in normal and pathological organs as a tool to identify “in situ” apoptotic cells both in the initial and late phases of apoptosis although further studies are needed in other organs to determine their usefulness and effectiveness over others identification techniques of “in situ” apoptosis.
Deep Search Engine [ Based on image representations and text ]

We present an image and text based image retrieval system that is built to scale. The image based image retrieval, or reverse image look-up, is based on similarity in their representations that were obtained by passing the image through a deep neural network. Text retrieval uses the words in the description of the image and calculates similarity. We use Flickr as the data source. We implement sharding of the text and images using TF-IDF vectors and KD-Trees respectively, for effective scaling.
Structure and Flexibility Adaptation in Nonspecific and Specific Protein-DNA Complexes

Interaction of regulatory DNA binding proteins with their target sites is usually preceded by binding to nonspecific DNA. This speeds up the search for the target site by several orders of magnitude. We report the solution structure and dynamics of the complex of a dimeric lac repressor DNA binding domain with nonspecific DNA. The same set of residues can switch roles from a purely electrostatic interaction with the DNA backbone in the nonspecific complex to a highly specific binding mode with the base pairs of the cognate operator sequence. The protein-DNA interface of the nonspecific complex is flexible on biologically relevant time scales that may assist in the rapid and efficient finding of the target site.
High-Throughput Growth Assay for Toxoplasma gondii Using Yellow Fluorescent Protein

ABSTRACT A high-throughput growth assay for the protozoan parasite Toxoplasma gondii was developed based on a highly fluorescent transgenic parasite line. These parasites are stably transfected with a tandem yellow fluorescent protein (YFP) and are 1,000 times more fluorescent than the wild type. Parasites were inoculated in optical-bottom 384-well culture plates containing a confluent monolayer of host cells, and growth was monitored by using a fluorescence plate reader. The signal was linearly correlated with parasite numbers over a wide array. Direct comparison of the YFP growth assay with the β-galactosidase growth assay by using parasites expressing both reporters demonstrated that the assays' sensitivities were comparable but that the accuracy of the YFP assay was higher, especially at higher numbers of parasites per well. Determination of the 50%-inhibitory concentrations of three known growth-inhibiting drugs (cytochalasin D, pyrimethamine, and clindamycin) resulted in values comparable to published data. The delayed parasite death kinetics of clindamycin could be measured without modification of the assay, making this assay very versatile. Additionally, the temperature-dependent effect of pyrimethamine was assayed in both wild-type and engineered drug-resistant parasites. Lastly, the development of mycophenolic acid resistance after transfection of a resistance gene in T. gondii was followed. In conclusion, the YFP growth assay limits pipetting steps to a minimum, is highly versatile and amendable to automation, and should enable rapid screening of compounds to fulfill the need for more efficient and less toxic antiparasitic drugs.
Role of Matrix Metalloproteinase-7 (Matrilysin) in Human Cancer Invasion, Apoptosis, Growth, and Angiogenesis

Matrix metalloproteinase (MMP)-7, also known as matrilysin, is a “minimal domain MMP” that exhibits proteolytic activity against components of the extracellular matrix (ECM). Matrilysin is frequently overexpressed in human cancer tissues and is associated with cancer progression. Tumorigenesis is a multi-step process involving cell growth, invasion, metastasis, and angiogenesis. Matrilysin has been shown to play important roles not only in degradation of ECM proteins, but also in the regulation of several biochemical processes such as activation, degradation, and shedding of non-ECM proteins. This minireview provides a summary of the current literature on the roles of matrilysin in tumorigenesis with a focus on the roles of modifications of non-ECM proteins by matrilysin and other related MMPs in tumorigenesis. Proteolysis of insulin-like growth factor binding protein by matrilysin results in increased bioavailability of insulin-like growth factors and enhanced cellular proliferation. Matrilysin has also been implicated in the ectodomain shedding of several cell surface molecules. Heparin-binding epidermal growth factor precursor (proHB-EGF) is cleaved by matrilysin into mature HB-EGF, which promotes cellular proliferation. Membrane-bound Fas ligand (FasL) is cleaved into soluble FasL, which increases apoptosis of cells adjacent to tumor cells. E-cadherin is converted to soluble E-cadherin to promote invasion. Tumor necrosis factor (TNF)-alpha precursor is cleaved to release soluble TNF-alpha to increase apoptosis. We propose that these matrilysin-mediated pathways provide the necessary and logical mechanisms to promote cancer progression.
Telemedicine in diabetic retinopathy: Access to rural India

Diabetic retinopathy (DR) is a growing concern in India. The first step in management of DR is timely screening. With 10% prevalence in rural India, 11 million people are likely to have DR by the year 2030. With limited resources and skilled manpower, it will not be possible to have routine eye examination to identify and treat these patients on a regular basis. Telemedicine is a possible answer in these situations where patients could be remotely screened and appropriately advised. With the advent of several technological advances such as low cost hand-held nonmydriatic camera, increased capabilities of the smartphones to take external eye and retinal photographs coupled with improving broadband connectivity; teleophthalmology in the management of DR could be a reality in the not too distant future.
New Trends and Solutions in Mobile Business

Nowadays the business medium requires anytime and anywhere connectivity. In an increasingly competitive business environment, more and more organizations need fast responses and instant results. Therefore, mobility changes the way companies do business; instant messaging, voice services, real-time LAN access, network access while traveling are transforming the business environment. In this context, WLANs are critical from the business point of view. The effectiveness with which employees make decisions drives to the success or failure of the business; thus, the business must enable employees to access the information needed to exceed corporate expectations. This article presents the key characteristics of the mobile business and analyzes a possible solution offered by a giant of the networking industry
Retailer buying behaviour: a review

With centralized buying organizations, growth in market coverage and turnover, retailers have become gateways to the consumer markets. Therefore, knowledge about retailers's and trade buyers' buying behaviour has become important to producers. We review the literature on retailer buying behaviour and find that research findings appear scattered and unrelated. Most of the previous research has been concerned with generating lists of criteria used by retailers when deciding whether or not to accept a new product. Other areas that have caught the interest of researchers are: the role of buying committees, the relationship with manufacturers, European buying alliances, the use of information, retail buyer task, sales staff influences, acceptances of trade deals, country or origin effects and new information technology.
Phase diagram of the half-filled 3D Hubbard model.

The antiferromagnetic Neel temperature T/sub N/ is calculated as a function of the Coulomb interaction U for a half-filled 3D Hubbard model. Numerical results are given for the specific heat and staggered magnetic suspectibility on periodic lattices ranging from 4/sup 3/--10/sup 3/ sites, and used to determine T/sub N/. The size dependence of the results suggests that the transition is weakly first order at small to intermediate values of U.
GB virus C and mortality from HIV infection.

Infection with the human immunodeficiency virus (HIV) is associated with conditions ranging from stability of the immune system and asymptomatic infection to severe compromise of the immune system and the development of AIDS.1 Before highly active antiretroviral therapy became available in 1996, the usual course of events for infected persons was depletion of the CD4+ T-cell population and the development of AIDS 8 to 10 years after the initial infection. In some exceptional cases, there was a more rapid progression of disease with a brisk rate of loss of CD4+ T cells. In contrast, in other rare cases, AIDS did .
Through the depths and heights of darkness; mothers as patients in psychiatric care.

INTRODUCTION This study attempts to contribute to the knowledge of caring science and mental health care by means of a profound understanding of the patients' existential world when being a mother in receipt of psychiatric care, with focus on inner processes such as health and suffering. Mothers struggle to cope with the demands of the illness and the responsibility for their children. They see themselves through their children and regard the child as an important part of themselves. Mothers experience guilt and shame related to motherhood, and when they have to relinquish their responsibility as a mother, they consider themselves a failure. Despite a range of practical and emotional difficulties, motherhood involved extremely positive experiences, which provide a purpose as well as fulfilment and meaning in life. METHODOLOGY This study is rooted in philosophical hermeneutics inspired by Gadamer with an inductive-deductive-abductive approach. Interpretation of the data was made on different levels of abstraction described as rational, contextual, existential and ontological. The point of departure was the caring science theory about health and suffering and the hermeneutic philosophy of understanding. RESULT OF THE INTERPRETATION The interpretation revealed the mothers' experiences of health and suffering as a struggle between the darkness of suffering and their inner source of strength. In the light of the theory of caring, the conscience became visible as the bearer of the human being's inner ethos of love and compassion. Experiences of health and suffering were interpreted as a struggle between guilt and responsibility, where conscience emerged as the road from ontological guilt to responsibility that leads the human being to what is true, beautiful and good in life.
Evaluation of Transport Services for VoIP

We study transport protocol performance from an application-specific perspective. Initially, we focus on TCP and UDP supportive role in the context of VoIP performance. Applying our metric for real-time performance, we discover that UDP has limited efficiency. Beyond UDP/TCP, we evaluate a solution-framework based on TCP protocols which incorporate variable congestion mechanisms. We also investigate VoIP traffic friendliness, as well as potential tradeoffs between protocol performance and fairness. Furthermore, we evaluate VoIP quality and protocol sensitivity versus a range of QoS parameter adjustments.
The Diagnosis of UTI: Concentrating on Pyuria

* Abbreviations: AB — : asymptomatic bacteriuria LE — : leukocyte esterase UTI — : urinary tract infection WBC — : white blood cell The term “pyuria” literally means “pus in the urine” but, in common usage, the focus is not on the presence of pus but on the number of white blood cells (WBCs) or amount of leukocyte esterase (LE) that exceeds a threshold and suggests a urinary tract infection (UTI). In this issue of Pediatrics , Chaudhari et al1 share the results of a study of the impact of urine concentration on the optimal threshold in the new era of automated urinalysis. Centrifugation of urine specimens has long been standard laboratory practice, presumably performed to concentrate sediment and facilitate the detection of cellular elements and bacteria. The implied (but questionable) assumption is that the process renders 1 spun specimen comparable to another in concentration. The “enhanced urinalysis”2 and automated urinalysis methods use analysis of unspun urine for cellular elements but have not attempted to control for concentration. The authors recognized concentration as a potential concern and demonstrated, with automated urinalysis, different thresholds for dilute and … Address correspondence to Kenneth B. Roberts, MD, 3500 Bramblewood Dr, Mebane, NC 27302. E-mail: kenrobertsmd{at}gmail.com
Grain-boundary effects on the magnetoresistance properties of perovskite manganite films.

The role of grain boundaries in the magnetoresistance (MR) properties of the manganites has been investigated by comparing the properties of epitaxial and polycrystalline films of ${\mathrm{La}}_{0.67}{D}_{0.33}\mathrm{Mn}{\mathrm{O}}_{3\ensuremath{-}\ensuremath{\delta}} (D=\mathrm{C}\mathrm{a},\phantom{\rule{0ex}{0ex}}\mathrm{S}\mathrm{r},\phantom{\rule{0ex}{0ex}}\mathrm{o}\mathrm{r}\phantom{\rule{0ex}{0ex}}\mathrm{v}\mathrm{a}\mathrm{c}\mathrm{a}\mathrm{n}\mathrm{c}\mathrm{i}\mathrm{e}\mathrm{s})$. While the MR in the epitaxial films is strongly peaked near the ferromagnetic transition temperature and is very small at low temperatures, the polycrystalline films show large MR over a wide temperature range down to 5 K. The results are explained in terms of switching of magnetic domains in the grains and disorder-induced canting of Mn spins in the grain-boundary region.
Research On Method Of PUCCH Channel Estimation Based On UCI Separate Coding

channel quality indicator and hybrid automatic repeat -request acknowledgement are important feedback information in system of 3GPP LTE, adopted joint or separate coding when transmitted via Physical uplink control channel. When uplink control information adopted type of joint coding, performance of channel estimation will decline and the number of reference signal will decrease because the ACK/NAK bits are embedded in one of the CQI reference signals. A program for uplink channel estimation is proposed for this issue. Simulation results show the effectiveness of the algorithm, which has been applied to TD-LTE wireless integrated test instrument.
Improvement in a quantitative measure of bradykinesia after microelectrode recording in patients with Parkinson's disease during deep brain stimulation surgery

It is widely accepted that patients with Parkinson's disease experience immediate but temporary improvement in motor signs after surgical implantation of subthalamic nucleus (STN) deep brain stimulating electrodes before the electrodes are activated, although this has never been formally studied. Based on anecdotal observations that limb mobility improved just after microelectrode recording (MER) during deep brain stimulation (DBS) procedures, we designed a prospective study to measure upper extremity bradykinesia using a quantitative measure of angular velocity. Measurements were made pre‐ and post‐MER and during intraoperative DBS. Analysis of 98 STN DBS procedures performed on 61 patients showed that MER did not create adverse clinical symptoms despite concerns that MER increases morbidity. Quantitative upper extremity bradykinesia improved after MER alone, and further improvement was seen during intraoperative DBS. Electrophysiological data from each case were then compared to the improvement in bradykinesia post‐MER alone and a significant correlation was found between the improvement in arm bradykinesia, the number of passes through the STN with somatosensory driving, and also with the number of arm cells with somatosensory driving in the STN, but not with total number of passes, total number of passes through the STN, or total number of cells with somatosensory driving in the STN. This study demonstrates that there is a significant improvement in upper extremity bradykinesia just after MER, before inserting or activating the DBS electrode in patients with Parkinson's disease who undergo STN DBS. © 2006 Movement Disorder Society