Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of the reporting-interval size on critical difference estimation: beyond "2.77".

BACKGROUND The reporting interval is the bin size used to report numerical pathology results and must be determined for every analyte. The influence of the size of the reporting interval on the critical difference (CD) between two results from the same patient has not been addressed previously. METHODS The effect of changing the reporting-interval size (RIS) on CDs was modeled by use of a spreadsheet application. The findings were applied to data on CDs with analytical precision values from our laboratory. RESULTS As the RIS increases relative to the combined analytical and within-person biological variation, there is an approximately linear increase in the CD from the value determined by use of published techniques. The revised estimate is as follows: CD = 2(1/2) x z x (SDa(2) + SDi(2))(1/2) + 1.5 x RIS, where CD, SD, and RIS are all in the same units. This effect is seen for any probability associated with the critical difference and for both uni- and bidirectional changes. CONCLUSIONS The choice of reporting interval should be made in the light of assay requirements. Where there is a clinical need for detection of small changes in analyte concentration, the reporting interval should be kept small relative to the combined variation attributable to assay precision and within-person biological variation.
Insulation systems for HVDC transformers: Present configurations, trends, challenges, solutions and open points

Examples of present configurations of insulation systems for windings and bushings in HVDC transformers are presented. Active trends are higher operating voltage (up to 1100 kV DC), more polarity reversals (PR) due to trading of energy and an increasing use of voltage sourced converters. There are several challenges to reliability of these units. Main ones are the uncertainty about oil electrical conductivity and the effectiveness of DC and PR tests. CIGRE Joint Working Group A2/D1.41 “HVDC transformer insulation - Oil conductivity” is preparing recommendations to address both issues. There is still considerable work to do in the characterization of insulating materials, in simulation of dielectric transients with ion drift for realistic insulation systems, in investigation of insulation behavior under both DC and AC stress and in monitoring oil conductivity over HVDC transformers life cycle.
Astera - A model for Multimodal IR with a Combined Approach of Structured and Non-structured Retrieval

Astera is a model for information retrieval on multimodal collections. We leverage different information sources to improve the effectiveness of a retrieval system. Taking into account both explicit and latent semantics present in the data can fertilize the potentiality to answer complex queries, not currently answerable neither by document retrieval systems, nor by semantic web systems. We provide a hybrid approach combining IR and structured search techniques. This model is under test with a multimodal collection.
Remous dans le creuset des temps : la Préhistoire à l'épreuve des traditions académiques (1850-1950)

La fondation intellectuelle de la Prehistoire a constitue une remise en question radicale du temps du passe humain. Paradoxal et insaisissable, ce temps immemorial a suscite des les origines de la discipline les approches les plus diverses. Retracer les metamorphoses du concept de temps en Prehistoire, c'est assister a un bouillonnement intellectuel complexe et parfois incoherent que l'historien des sciences doit s'interdire d ordonner en fonction de schemas de pensee actuels. Pour cela, notre propos se developpera autour de trois figures emblematiques du recit historio graphique : Edouard Lartet, Gabriel de Mortillet et l'abbe Breuil. Les travaux de ces auteurs serviront de points de depart pour explorer dans leur complexite trois moments importants de l'histoire de l'archeologie prehistorique. Nous chercherons ainsi a degager la dynamique d'evolution des idees dans une discipline au carrefour de diverses traditions academiques.
Telomerase Activity in Body Cavity Fluid and Peritoneal Washings in Uterine and Ovarian Cancer

The telomeric repeat amplification protocol (TRAP) assay was used to measure telomerase activity in body cavity fluid from 10 ovarian cancer patients (ascites, 9; pleural fluid, 1), ascites and peritoneal washings from eight uterine corpus cancer patients, and ascites from one with cancer of the uterine cervix. Telomerase activity was observed in five of six (83.3%) samples with positive cytology, one of four (25%) samples with suspicious cytology and one of nine (11.1%) samples with negative cytology. A high level of activity was observed in samples containing large numbers of blood-cell components, which could be removed without inactivating the telomerase by treating the samples with Nycodenz (N, N1-Bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl) acetamide]2,4,6-triiodo-isophtalamide). In two patients with ovarian cancer treated with anticancer drugs, 5 and 7 days after treatment, intracellular vacuoles and multinucleation were observed in ascites tumour cells, and telomerase activity decreased. At 14 to 21 days after treatment, the ascites tumour cell morphology was the same as before treatment, and telomerase activity rose once again. The TRAP assay is a sensitive method of detecting telomerase in cytological material and may provide a useful adjunct to cytological diagnosis.
Tyrosine Phosphoproteomics of Fibroblast Growth Factor Signaling

Signal transduction by receptor tyrosine kinases is initiated by recruitment of a variety of signaling proteins to tyrosine-phosphorylated motifs in the activated receptors. Several signaling pathways are thus activated in parallel, the combination of which decides the cellular response. Here, we present a dual strategy for extensive mapping of tyrosine-phosphorylated proteins and probing of signal-dependent protein interactions of a signaling cascade. The approach relies on labeling of cells with “heavy” and “light” isotopic forms of Arg to distinguish two cell populations. First, tyrosine-phosphorylated proteins from stimulated (“heavy”-labeled) and control samples (“normal”-labeled) are isolated and subjected to high sensitivity Fourier transform ion cyclotron resonance mass spectrometry analysis. Next, phosphopeptides corresponding to tyrosine phosphorylation sites identified during the tyrosine phosphoproteomic analysis are used as baits to isolate phosphospecific protein binding partners, which are subsequently identified by mass spectrometry. We used this approach to identify 28 components of the signaling cascade induced by stimulation with the basic fibroblast growth factor. Insulin receptor substrate-4 was identified as a novel candidate in fibroblast growth factor receptor signaling, and we defined phosphorylation-dependent interactions with other components, such as adaptor protein Grb2, of the signaling cascade. Finally, we present evidence for a complex containing insulin receptor substrate-4 and ShcA in signaling by the fibroblast growth factor receptor.
Do silicone breast implants affect breastfeeding?

QUESTION One of my patients has silicone breast implants. She gave birth to a healthy baby boy but is afraid to breastfeed because she read in a magazine that the baby might be affected by silicone secreted in the milk. How should I advise her? ANSWER Neither silicone nor its components could be measured in the breast milk of women with silicone implants. Your patient should be able to breastfeed safely.
Planes de desarrollo económico-social y calidad de la educación en Colombia

El presente texto es una reflexion que se inscribe dentro de los analisis de los lexicos dominantes en la educacion superior colombiana entre 1993 y 2012, con los cuales se anuncia un cambio de enfasis en la valoracion social de la educacion en su conjunto. Se parte de una descripcion de la relacion entre la sociedad y la educacion y se insinuan las variaciones sufridas por esta ultima en las concepciones de las personas y su importancia social. Se toman como referencia los planes de desarrollo economico y social en Colombia para el periodo estudiado y se muestran como son explicitos y enfaticos los lenguajes alusivos a la educacion como mercancia. En especial, se reconoce un viraje en el contexto de la educacion superior hacia expresiones como eficiencia, eficacia, competencia, desarrollo, productividad, competitividad, mercado mundial, estandarizacion, credito, mejoramiento de la calidad, autosostenibilidad, entre otros.
Research in Acute Lung Injury and Pulmonary Fibrosis Surfactant replacement therapy reduces acute lung injury and collapse induration-related lung remodeling in the bleomycin model

Surfactant replacement therapy reduces acute lung injury and collapse induration-related lung remodeling in the bleomycin model. Am J Physiol Lung Cell Mol Physiol 313: L313–L327, 2017. doi:10.1152/ajplung.00033. 2017. —Bleomycin-induced lung injury leads to surfactant dysfunction and permanent loss of alveoli due to a remodeling process called collapse induration. Collapse induration also occurs in acute interstitial lung disease and idiopathic pulmonary ﬁbrosis in humans. We hypothesized that surfactant dysfunction aggravates lung injury and early remodeling resulting in collapse induration within 7 days after lung injury. Rats received bleomycin to induce lung injury and either repetitive surfactant replacement therapy (SRT: 100 mg Curosurf/kg BW (cid:2) surf group) or saline (0.9% NaCl (cid:2) saline group). After 3 (D3) or 7 (D7) days, invasive pulmonary function tests were performed to determine tissue elastance (H) and static compliance (Cst). Bronchoalveolar lavage (BAL) was taken for surfactant function, inﬂammatory markers, and protein measurements. Lungs were ﬁxed by vascular perfusion for design-based stereology and electron microscopic analyses. SRT signiﬁcantly improved minimum surface tension of alveolar surfactant as well as H and Cst at D3 and D7. At D3 decreased inﬂammatory markers including neutrophilic granulocytes, IL-1 (cid:3) , and IL-6 correlated with reduced BAL-protein levels after SRT. Numbers of open alveoli were signiﬁcantly increased at D3 and D7 in SRT groups whereas at D7 there was also a signiﬁcant reduction in septal wall thickness and parenchymal tissue volume. Septal wall thickness and numbers of open alveoli highly correlated with improved lung mechanics after SRT. In conclusion, reduction in surface tension was effective to stabilize alveoli linked with an attenuation of parameters of acute lung injury at D3 and collapse induration at D7. Hence, SRT modiﬁes disease progression to collapse induration.
Factors Associated With the Thickness of the Ligamentum Flavum: Is Ligamentum Flavum Thickening Due to Hypertrophy or Buckling?

Study Design. Ligamentum flavum (LF) thickness was measured by using lumbar magnetic resonance imaging in patients with low back or leg pain. Objective. This study investigated whether LF thickening is due to hypertrophy or buckling related to disc degeneration and examined the correlations between the thickness of the LF and age, sex, body mass index (BMI), degree of pain, lumbar spinal stenosis (LSS), and disc herniation. Summary of Background Data. “LF thickness” and “LF hypertrophy” are used interchangeably in the literature, although they are not necessarily the same thing. Thickness may increase by buckling without a change in the mass of the LF, and whether LF thickening is due to tissue hypertrophy or buckling remains controversial. Methods. The thickness of 896 LFs at the L2–L3, L3–L4, L4–L5, and L5–S1 levels of 224 (mean age, 47.8 ± 16.7 yrs) patients was measured prospectively on axial T1-weighed magnetic resonance images, obtained at the facet joint level. The presence of disc degeneration, spinal stenosis, and disc herniation was evaluated. Results. At all of the levels investigated, LF thickness was significantly greater in patients with grades IV to V degeneration compared with the patients with grades I to III degeneration (P < 0.05). LF thickness at all levels increased significantly with age (P < 0.05). Sex and the degree of pain were not correlated with the thickness of the LF. Patients with a BMI of 25 kg/m2 or greater had the thickest LF at the L3–L4 level (P < 0.01). LF thickness was significantly greater at the L2–L3, L3–L4, and L4–L5 levels in subjects with LSS and significantly greater at all levels in subjects with disc herniation (P < 0.05). Conclusion. Thickening of the LF is correlated with disc degeneration, aging, BMI, LSS, spinal level, and disc herniation. The authors concluded that thickening of the LF is due to buckling of the LF into the spinal canal secondary to disc degeneration more than to LF hypertrophy. Sex and the degree of pain were not correlated with the thickness of the LF.
Interference in the resonance fluorescence of two incoherently coupled transitions

The fluorescence light emitted by a four-level system in J=1/2 to J=1/2 configuration driven by a monochromatic laser field and in an external magnetic field is studied. We show that the spectrum of resonance fluorescence emitted on the {pi} transitions shows a signature of spontaneously generated interference effects. The degree of interference in the fluorescence spectrum can be controlled by means of the external magnetic field, provided that the Lande g factors of the excited and the ground state doublet are different. For a suitably chosen magnetic field strength, the relative weight of the Rayleigh line can be completely suppressed, even for low intensities of the coherent driving field. The incoherent fluorescence spectrum emitted on the {pi} transitions exhibits a very narrow peak whose width and weight depend on the magnetic field strength. We demonstrate that the spectrum of resonance fluorescence emitted on the {sigma} transitions shows an indirect signature of interference. A measurement of the relative peak heights in the spectrum from the {sigma} transitions allows us to determine the branching ratio of the spontaneous decay of each excited state into the {sigma} channel.
Semantically-Enabled Context-Aware Abbreviations Expansion in the Clinical Domain

Abbreviations (aka acronym, shorthand, initialism) constitute an important part of the textual description of a clinical study. However, detecting their meaning may be rather difficult not only for software agents but also humans since a considerable amount of them is not accompanied by their long form (aka expansion), while, in general, every abbreviation has more than one possible meaning (aka sense) on average. Moreover, even in cases that the abbreviations are specified in the document, detecting their expansion may be still difficult due to partial or non-similarity among them. For this purpose a system has been developed for detecting the meaning of abbreviations used in clinical studies. In the background innovative algorithms and techniques have been used for both abbreviation recognition and suggestion purposes. The evaluation of the system developed was based on an abbreviations-annotated corpus of clinical studies developed in close collaboration with clinical experts.
Convergence of ℓ2/3 Regularization for Sparse Signal Recovery

In this paper, we consider the problem of finding the sparsest solution to underdetermined linear systems. Unlike the literatures which use the l1 regularization to approximate the original problem, we consider the l2/3 regularization which leads to a better approximation but a nonconvex, nonsmooth, and non-Lipschitz optimization problem. Through developing a fixed point representation theory associated with the two thirds thresholding operator for l2/3 regularization solutions, we propose a fixed point iterative thresholding algorithm based on two thirds norm for solving the k-sparsity problems. Relying on the restricted isometry property, we provide subsequentional convergence guarantee for this fixed point iterative thresholding algorithm on recovering a sparse signal. By discussing the preferred regularization parameters and studying the phase diagram, we get an adequate and efficient algorithm for the high-dimensional sparse signal recovery. Finally, comparing with the existing algorithms, such as the standard l1 minimization, the iterative reweighted l2 minimization, the iterative reweighted l1 minimization, and iterative Half thresholding algorithm, we display the results of the experiment which indicate that the two thirds norm fixed point iterative thresholding algorithm applied to sparse signal recovery and large scale imageries from noisy measurements can be accepted as an effective solver for l2/3 regularization.
Wilsvrijheid en strafrechtelijke verantwoordelijkheid

De wilsvrijheid wordt wel de meest intieme vorm van vrijheid genoemd (zie Mooij 2004, p. 94, 139). Zij heeft betrekking op de bij uitstek aan mensen toegedachte bekwaamheid om te reflecteren op de eigen wil. Het strafrechtelijke concept van de wilsvrijheid is analoog aan dat binnen de voor-juridische leefwereld: beide concepten duiden in de grond op de gedachte dat de mens beschikt over de principiele mogelijkheid om afstand te nemen van de situatie waarin hij zich bevindt, van de verlangens, wensen, overtuigingen die zich aan hem opdringen, en daarop vervolgens terug te buigen ofwel te reflecteren (Slors 2012, p. 123; Mooij 2012, p. 48, 135-138; Korsgaard 1996). Men is in deze diepere zin vrij wanneer men in staat is om niet alleen de eigen voorkeur die men gewaar wordt te volgen, maar ook de eigen voorkeur eventueel niet te volgen en wel omdat men deze voorkeur bij nader inzien niet wil volgen.
Testing the Efficacy of Chaplaincy Care

The current article reviews the research conducted in the United States on the clinical practice of chaplains with patients and family members, referrals to chaplains, patient satisfaction with chaplaincy services, and the limited literature on the efficacy of chaplain interventions. It also discusses the methodological limitations of studies conducted on these topics and makes suggestions for improving future chaplaincy research. The authors conclude that past studies have not adequately defined chaplain interventions, nor sufficiently documented the clinical practice of chaplains, and that more and better designed studies are needed to test the efficacy of chaplaincy interventions. The authors recommend that chaplains generate research-based definitions of spirituality, spiritual care, and chaplaincy practice; and that more research be conducted to describe the unique contributions of chaplains to spiritual care, identify best chaplaincy practices to optimize patient and family health outcomes, and test the efficacy of chaplaincy care.
Pepino mosaic virus triple gene block protein 1 (TGBp1) interacts with and increases tomato catalase 1 activity to enhance virus accumulation.

Various plant factors are co-opted by virus elements (RNA, proteins) and have been shown to act in pathways affecting virus accumulation and plant defence. Here, an interaction between Pepino mosaic virus (PepMV) triple gene block protein 1 (TGBp1; p26) and tomato catalase 1 (CAT1), a crucial enzyme in the decomposition of toxic hydrogen peroxide (H₂O₂), was identified using the yeast two-hybrid assay, and confirmed via an in vitro pull-down assay and bimolecular fluorescent complementation (BiFC) in planta. Each protein was independently localized within loci in the cytoplasm and nuclei, sites at which their interaction had been visualized by BiFC. Following PepMV inoculation, CAT mRNA and protein levels in leaves were unaltered at 0, 3 and 6 days (locally) and 8 days (systemically) post-inoculation; however, leaf extracts from the last two time points contained increased CAT activity and lower H₂O₂ evels. Overexpression of PepMV p26 in vitro and in planta conferred the same effect, suggesting an additional involvement of TGBp1 in potexvirus pathogenesis. The accumulation of PepMV genomic and subgenomic RNAs and the expression of viral coat protein in noninoculated (systemic) leaves were reduced significantly in CAT-silenced plants. It is postulated that, during PepMV infection, a p26-CAT1 interaction increases H₂O₂ cavenging, thus acting as a negative regulator of plant defence mechanisms to promote PepMV infections.
Galaxy and Mass Assembly (GAMA): Exploring the WISE Web in G12

We present an analysis of the mid-infrared Wide-field Infrared Survey Explorer (WISE) sources seen within the equatorial GAMA G12 field, located in the North Galactic Cap. Our motivation is to study and characterize the behavior of WISE source populations in anticipation of the deep multiwavelength surveys that will define the next decade, with the principal science goal of mapping the 3D large-scale structures and determining the global physical attributes of the host galaxies. In combination with cosmological redshifts, we identify galaxies from their WISE W1 (3.4 μm) resolved emission, and we also perform a star-galaxy separation using apparent magnitude, colors, and statistical modeling of star counts. The resulting galaxy catalog has ≃590,000 sources in 60 deg2, reaching a W1 5σ depth of 31 μJy. At the faint end, where redshifts are not available, we employ a luminosity function analysis to show that approximately 27% of all WISE extragalactic sources to a limit of 17.5 mag (31 μJy) are at high redshift, . The spatial distribution is investigated using two-point correlation functions and a 3D source density characterization at 5 Mpc and 20 Mpc scales. For angular distributions, we find that brighter and more massive sources are strongly clustered relative to fainter sources with lower mass; likewise, based on WISE colors, spheroidal galaxies have the strongest clustering, while late-type disk galaxies have the lowest clustering amplitudes. In three dimensions, we find a number of distinct groupings, often bridged by filaments and superstructures. Using special visualization tools, we map these structures, exploring how clustering may play a role with stellar mass and galaxy type.
Design factors in multicast service delivery using the optical layer in core and metro networks

As optical switching and multiplexing architectures evolve, optical multicast keeps on being a capability advertised by a few core and transport optical equipment vendors. However, to the date, not much use of this service has been made by operators. This work addresses the reasons behind this fact, identifies the key technical design factors in a multicast-capable network and the challenges to face for an effective use of multicast at the optical layer.