Miracle-dz/UniFAR-FTUs huggingface dataset:
A Pilot Study of Teachers' Perceptions of Two Handwriting Curricula: Handwriting Without Tears and the Peterson Directed Handwriting Method

The purpose of this study was to explore first grade teachers' perceptions of handwriting curricula (the Peterson Directed Method and Handwriting Without Tears) to better understand the collaborative process that can support decision making. A qualitative method was used as quarterly journals from six first grade teachers were analyzed using the constant comparative method. Through this, the following themes emerged: teacher satisfaction, effectiveness, student preference and engagement, and curriculum adaptations. These themes indicate that teachers perceived Handwriting Without Tears to be easy to implement, engaging, and effective without curriculum adaptations, whereas the Peterson Directed Method was effective in promoting student success with curriculum adaptations.
Effect of Transforming Growth Factor-beta (TGF-) on Mammary Development

Abstract Mammary growth and development in heifers and cows is regulated by a complex interaction of multiple stimuli, including environmental, nutritional, and endocrine factors. The action of these various stimuli is mediated by a host of growth factors, including transforming growth factor-beta (TGF- β ). TGF- β is a potent inhibitor of mammary epithelial cell growth and regulates extracellular matrix composition. TGF- β is expressed during bovine mammary development and its expression is particularly high at times of mammary growth and reorganization. The purpose of this paper is to review what we know about TGF- β and mammary growth and to explain how TGF- β affects the cell cycle in a normal epithelial cell line.
Type 2 Diabetes and Hashimoto Thyroiditis-Possible Associations and Clinical Correlations - Preliminary Results

Abstract Background and aims: The primary objective is to evaluate the possible relationship between Type 2 Diabetes (T2DM) and Hashimoto Thyroiditis (HT), since the only correlation described until now is between Type 1 Diabetes and HT based on the autoimmune mechanism. The secondary end-point is to evaluate if there is a correlation between the characteristics of Type 2 Diabetes and autoimmune thyroiditis and if the metabolic component may be a factor of association. Material and method: We designed a retrospective, observational research, enrolling patients from “Sanamed” Hospital from Bucharest. Between 2016 and 2017 in our clinic a number of 150 patients were enrolled, in the following groups: 50 only with T2DM, 50 only with HT and 50 with both T2DM and HT. Results: The main observations of the study were the following: the prevalence of obesity was higher in patients with T2DM (p<0.001) than in the group with HT (p<0.001); Dyslipidemia was higher in the HT group (p<0.001) than in the group of T2DM (p<0.001); Ischemic cardiac disease was more frequent in the HT group (p<0.001) than in the Diabetes group (p<0.001); in the group that had both T2DM and HT, the HbA1c was correlated with pre-existing Thyroid pathology (p<0.001), also Dyslipidemia was associated with hepatic steatosis (p<0.001). Conclusions: After assessing all the parameters we have reached the conclusion that there is an association between the characteristics of T2DM and HT, as well as an interaction between these two diseases, considering their metabolic component.
Information Systems Effectiveness

The evaluation of Information Systems success is a subject that has been widely studied in recent years. The present document aims to demonstrate an analysis carried out on the two main approaches regarding this subject, as follows: from a purely academic basis, the DeLone, McLean and Pitt approach, and from a business environment basis, the ISO/IEC 20000 approach. It was also carried out a study on how the two approaches are complementary and still, held a proposal for joint use of them. In order to evaluate the success/effectiveness of Information Systems of a business group/organization, a case study was produced using a service quality performance tool – SERVQUAL. Finally, an overall conclusion is carried out, bearing in mind the bridge between theory and practice.
Post-Modern Ideas in Substance Abuse Treatment

ABSTRACT This article describes the use of post-modern ideas in the treatment of substance abusers at a long term residential and day treatment center. It describes some of the changes that ensued as a result of a transformation from a “therapeutic community” (TC) model to a “solution-focused” model. The TC is a deficit model that focuses on a person's flaws and weaknesses. Solution-focused therapy, on the other hand, focuses on what a person has done and is doing right and his or her strengths, assets, and resources. This approach not only improves the quality and effectiveness of substance abuse treatment for clients, but also creates a better working environment for staff.
The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling

The interferon alpha receptor (IFNAR) and T-cell receptor (TCR) are expressed upon the T-cell surface. The dimeric Class I interferon receptor is a cytokine receptor that recognises interferons such as IFNα. Interferons (IFNs) are pluripotent, antiviral cytokines that causes antiproliferative effects, primarily through Jak/STAT signalling. The T-cell receptor is an antigenic receptor that recognises antigenically-derived peptides in the context of the MHC complex located on an antigen presenting cell, resulting in a cellular proliferation. Although both receptors elicit opposing cellular outcomes, both the TCR and IFNAR activate the ERK MAPK signalling pathway, albeit with a different time course. Furthermore, studies have shown that the IFNAR and TCR utilise an overlapping subset of proteins for this pathway to occur such as CD45, Lck and Zap70. In this study evidence is presented to show that two further TCR-associated proteins are phosphorylated in response to the IFNAR; the 95kDa guanosine nucleotide exchange factor, Vav, and the 76kDa adaptor protein Slp76. This proceeds in a similar manner to that observed at the TCR. Furthermore, the absence of either protein impairs IFNAR-induced ERK MAPK signalling. The similarities between TCR and IFNAR signalling led to questioning of whether crosstalk occurs between the two receptors. To address this possibility a TCRβ deficient cell line, which lacks functional TCR expression, was utilised. It was demonstrated that the absence of the TCR completely abrogates the ERK MAPK response emanating from the IFNAR yet Jak/STAT signalling is unaffected. These results highlight for the first time an intimate connection between the TCR and IFNAR.
Stealing into the wild: conservation science, plant breeding and the makings of new seed enclosures

Faced with pressing climatic changes, scientific and industrial interests are vying to develop crops that can survive drought, floods and shifting pest regimes. Increasingly, they look for solutions in an unlikely place: the gene pools of wild plants. Crop wild relatives (CWR) – species closely related to crops, including their ancestors – offer breeders the allure of retracing the domestication bottleneck, infusing genomes of modern crops with ‘lost’ genetic variety. Yet wild relatives also confront threats from climate change, urbanization and expansion of industrial agri-food. Thus, CWR, seen as both salvational and threatened, have become an international conservation and food-security priority. It is my contention that, in their common project to harness wild-relative potential, conservation and breeding science are co-evolving to extend seed commodity relations into new spheres. I examine enclosures along two fronts: first within ‘systematic CWR conservation’, where ‘in situ’ approaches, typically regarded as empowering and sustainable alternatives to ‘ex situ’, instead may support a complementary system of value extraction; second, in breeding and biotechnology research, which produces new value for CWR while profoundly shaping upstream conservation priorities. An important finding is that although today’s ‘ex situ-centric’ complementarity favors dispossession, an ‘in situ-centric’ approach could foster democratic renewal of biocultural diversity.
Creative Relations

Reporting about a project with male home carers, this paper presents some of the interactions, which took place between the participants as they got to know each other, becoming part of each other’s lives. Presenting information from the artist’s personal diaries as someone who has lived in the participating community all his life, he attempts to reveal the importance of seemingly insignificant data by making diary entries after each event and reflecting on them at a later date. These have been selected to compare the similarities between Tim Ingold’s descriptions of creativity and Grant Kester’s model for a dialogical aesthetic, which highlights key points in the engagement processes of a socially engaged artist. These reflective notes, made while the experiences were still fresh in his mind, help to illustrate the impact not only on the participants but also upon the artist as a participant in the social process.
Taking advantage of genomic data to develop reliable microsatellite loci in Trypanosoma brucei

Taking advantage of the annotated genome of Trypanosoma brucei, a unicellular eukaryotic parasite which causes sleeping sickness across sub-Saharan Africa, this study develops 11 variable microsatellite loci, which reliably amplify in poor and unknown quality DNA samples. We provide insights into effective screening methods to develop microsatellite loci from genomic resources and a set of markers to study regional population variation in this important parasite. Page 2 of 22 Molecular Ecology Resources
Knowledge and attitudes towards vitamin D food fortification

Purpose Vitamin D deficiency is a well-recognised public health problem within the UK, with specific population groups more vulnerable to deficiency. Two pilot studies were used to explore awareness of vitamin D deficiency and attitudes towards food fortification. Design/methodology/approach A survey of 120 participants from five at-risk groups (South Asians, Blacks, Middle Eastern, Far Eastern and Caucasian older adults over 65 years) plus a group of British Caucasians who do not avoid sun exposure explored awareness of vitamin D, sun exposure knowledge and behaviour and attitudes towards food fortification. The latter group was included to provide a comparison group who were at a reduced risk of deficiency. χ2 was used to test associations between categorical variables and the study groups. The second study used three focus groups and two interviews, conducted on young South Asian females and examined knowledge and awareness of vitamin D and vitamin D-fortified foods. Findings A lack of knowledge and misconceptions were highlighted by both studies in relation to at-risk factors, including sunlight exposure (p = 0.037), dietary intakes (p = 0.0174) and darker skin pigmentation (p = 0.023), sources of vitamin D and the health benefits associated with optimal consumption. Attitudes to mandatory fortification of some foods varied significantly (p = 0.004) between the groups with acceptance rates for Blacks (68 per cent), those over 65 years (50 per cent), Middle Eastern (67 per cent) and Far Eastern (73 per cent), whereas the control (71 per cent) showed no acceptance, and South Asians gave a mixed response (48 per cent No). Focus group findings highlighted positive views towards fortification, although this was less for mandatory as opposed to voluntary fortification. Both pilot studies highlight the need for more research into this area, to create more effective public health policies. Originality/value The research presents novel insights into a topical area where there is limited research.
AB0627 Physical activity by self-reported physical activity and lupus nephritis in patients with systemic lupus erythematosus

Background Physical activity is found to be associated with clinical status such as disease activity, organ damage, disability, fatigue, and quality of life in systemic lupus erythematosus (SLE). Objectives The aim of this study was to identify the association between physical activity and disease activity and organ damage in patients with SLE. Methods A total of 415 patients with SLE were consecutively enrolled from KORean lupus Network (KORNET) registry. This registry assessed clinical features, disease activity Systemic Lupus Erythematosus Disease Activity Index 2000 [SLEDAI-2K]), and disease damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology [SLICC/ACR] damage index [SDI]) at the enrollment of study. Self-reported physical activity was measured by International Physical Activity Questionnaire (IPAQ). Statistical analyses were used by Mann-Whitney U test and multivariate logistic regression analysis. Results There is significant difference of vigour activity between patients with lupus nephritis (n=93) and without lupus nephritis (n=322) (p=0.012), but not moderate and walking activities. In contrast, the differences of each physical activity, walking, moderate, and vigorous intensity, according to SLEDAI-2K and SDI were not found. In addition to high PCS of SF-36 (p=0.006) and SLEDAI-2K (p=0.038), less vigorous physical activity were related with lupus nephritis (p=0.033). However, the risk of CVD was not associated with physical activity of SLE. Conclusions This study showed that patients with lupus nephritis had less vigorous physical activity. It implicates that SLE-related organ damage might be associated with levels of physical activity. References [1] Costenbader KH, Wright E, Liang MH, Karlson EW. Cardiac risk factor awareness and management in patients with systemic lupus erythematosus. Arthritis Rheum2004;51:983–8. [2] Katz P, Julian L, Tonner MC, Yazdany J, Trupin L, Yelin E, Criswell LA. Physical activity, obesity, and cognitive impairment among women with systemic lupus erythematosus. Arthritis Care Res (Hoboken)2012;64:502–10. Disclosure of Interest None declared
Assessment of anemia in pregnant women at a tertiary care centre in Western Maharashtra, India

Introduction: Deficiency of anemia is a prevalence cause of nutritional deficiency, lacking intake of iron-rich food and lower bioavailability of consumed iron required during pregnancy. Objective: To assess the rate in pregnant women with lower haemoglobin for the determination if cause of anemia and to calculate daily caloric intake of anemia. Materials and Methods: A tertiary care health institute based study carried out with enrolled patients from January 2007 to June 2009. A total of 113 pregnant women with low haemoglobin concentration, and less and controlled group respectively were included in the study. Results: Out of 113 pregnant women divided into two groups, in group one, 30 pregnant women had haemoglobin concentration of 5gm% and group two, 83 pregnant women had haemoglobin concentration between 5.1 to 7gm. The duration of pregnancy anemia detection were non significance (p = < 0.06327) and quantitative calorie intake deficit were find highly significant (p = 0.000004) between all groups. The types of anemia were detected in both groups are Microcytic hypochromic, Dimorphic, Megaloblastic, Normocytic anemia. Hence, higher cause of anemia in both groups due to nutritional deficiency. Total 55.56% pregnant women presented with 60-80 ug/dl serum iron level. Overall 3 maternal deaths (2 deaths in group 1 and 1 death in group 2) were resulted out of 113 pregnant women. Conclusions: The higher rates of mortality were detected in lower haemoglobin level group, which shows high risk mortality in pregnant women with low level of blood.
Inhibition of Cell Division

The danger inherent in formulating specific models to explain physicsl- biological phenomena is discussed. Some of the phenomenological observations on effects of ionizing radiations on cell division in yeast are reviewed. Recent observations made on the modification of radiation damage in yeast by various envirommental agents are described. These findings are analyzed within the frameworks of the generalized migration model of Zirkle and Tobias and of the modified directaction model formulated by Alper, Howard-Flanders, Alexander, and others. 34 references. (C.H.)
Living on the edge: benefit-sharing from protected area tourism

Abstract Tourism in protected areas not only plays an essential role in terms of contributing to the financial sustainability of protected areas but through effective and efficient benefit-sharing can positively impact numerous stakeholders within and beyond the protected area. This paper provides a brief analysis of the evolution of benefit-sharing from protected area tourism, discussing tangible and intangible benefits and highlighting that revenue-sharing is only one way of sharing benefits from tourism and protected areas. The paper highlights the complexity of benefit-sharing, the importance of identifying all relevant stakeholders, the challenges of ensuring equity and sustainability and the critical importance of good governance. The evolution of benefit-sharing mechanisms over time emphasises a continuing need to evolve and adapt to each unique situation, as much evidence indicates that little has changed for those living on the edge. Although this paper focuses on benefit-sharing from protected area tourism, it is essential to acknowledge that along with these benefits are costs associated with tourism, including possible increased local prices, loss of access to land, human-wildlife conflict, and other related costs. Recommendations for future research are included to encourage an ongoing evolution and improvement in benefit-sharing mechanisms.
Foreword

This special issue of the Journal of Nonprofit & Public Sector Marketing consists of articles resulting from the inaugural conference “Social Marketing Advances in Research and Theory” (SMART), held September 16-18, 2004 in Kananaskis, Alberta Canada. The conference was sponsored by the Centre for Socially Responsible Marketing at the University of Lethbridge, Canada, in conjunction with the Society for Consumer Psychology. SMART was an intimate conference that brought together academics and practitioners from around the globe to present their original social marketing research. Over 50 participants from seven countries were in attendance. The purpose of the conference was to provide an opportunity for researchers to share their work in a peer-reviewed, competitive paper format. This resulted in many high quality articles published here. As both a practice and a field of academic study, social marketing is a process tool. Philip Kotler and his colleagues have been instrumental in this evolutionary process. One of the first definitions of social marketing was put forward by Kotler and Zaltman (1971):
Rural development through the construction of new, nested, markets: comparative perspectives from China, Brazil and the European Union

This article discusses and compares the rural development processes and practices currently occurring in China, Brazil and the European Union. Although these are strongly rooted in the specificities of time and space, they also share important commonalities. We argue that rural development can be viewed as an evolving set of responses to market failures. A key element of these responses is that they are unfolding through the construction of new markets: a seemingly contradictory phenomenon that has, as yet, hardly been scrutinized or theoretically elaborated. We describe these newly emerging markets as ‘nested markets’ and support our argument with a careful reconsideration of the dynamics of long-established nested markets. We then extend this analysis, firstly, by arguing that the construction of such new markets occurs through a process of social struggle and, secondly, by exploring the strength of these newly emerging constellations in relation to the hegemony exerted by food empires. Our analysis puts common-pool resources, which underlie these new, nested markets, centre stage.
Book Review—Jesse Walker, Rebels On The Air: An Alternative History Of Radio In America

Slotten's thesis is that much should be learned from the early regulatory history, and the basic concerns remain today: For example, his engaging Epilogue (pp. 232-244) and Note on Secondary Sources (pp. 293-299), offer evidence that government's "important role in stimulating technological innovations" is one of the "traditional themes" of broadcast regulation (p. 243). He probably does not go far enough in suggesting that this tendency exists for all emerging media, such as the Internet. Likewise, a communication scholar might connect this vital thread to Everett Rogers' (1995) Diffusion of Innovations. From this perspective, policy actors may be considered innovators spurring an early majority of adapters-critical to sparking a sustained cycle of adoption. It is important to recognize, as radio scholars have with the failed case of AM Stereo, that policy initiatives sometimes fal l flat on their face. Slotten's work will be a "must-read" for those researching radio regulation, but it is not likely to find a large following among classroom teachers. Instead, it offers a useful supplementary reference for those seeking to understand the seminal period in the history of electronic media regulation.
SOMATOTROPIN RESPONSE TO CORTICOSTERONE AND THE THYROID HORMONE T3 DURING CHICK EMBRYONIC DEVELOPMENT: INVOLVEMENT OF TYPE I AND TYPE II GLUCOCORTICOID RECEPTORS

Title of Thesis: SOMATOTROPIN RESPONSE TO CORTICOSTERONE AND THE THYROID HORMONE T3 DURING CHICK EMBRYONIC DEVELOPMENT: INVOLVEMENT OF TYPE I AND TYPE II GLUCOCORTICOID RECEPTORS Kristina Anne Heuck, M.S., 2004 Thesis Directed By: Associate Professor Tom E. Porter, Department of Animal and Avian Sciences Corticosterone (CORT) can stimulate growth hormone (GH) cell (somatotroph) differentiation and GH secretion on embryonic day (e) 12 but not e20 in the chicken. GH induction involves both glucocorticoid receptors (GR) and mineralocorticoid receptors (MR); however, this finding has been characterized only on e12. To further define changes in somatotroph responsiveness to CORT, pituitary cells obtained on e12-e20 were cultured with CORT alone and in combination with T3. GH secretion increased over basal with CORT treatment on e12, e14, e16, and e18, but not e20. Contributions of GR and MR in CORT responses were evaluated using GR and MR antagonists. Blocking both receptors was required to abolish the CORT response by e12 cells. The same treatment on e20 decreased GH secretion relative to basal. We conclude that positive somatotroph responses to CORT are lost during embryonic development and that both GR and MR mediate CORT-induced GH secretion by cultured somatotrophs. SOMATOTROPIN RESPONSE TO CORTICOSTERONE AND THE THYROID HORMONE T3 DURING CHICK EMBRYONIC DEVELOPMENT: INVOLVEMENT OF TYPE I AND TYPE II GLUCOCORTICOID RECEPTORS
How can we Make Food Risk Communication Better: Where are we and Where are we Going?

Over the past number of years the reporting of food scares, particularly in European context, have grown in prevalence. These scares are more often than not amplified by the media leading to greater pressure on regulators, industry and other stakeholders to communicate the actual risks associated with the food issue in question accurately. The aims of this paper is three fold: firstly, provide a brief background on the history of risk communication itself. Secondly, to summarise some of the main theoretical avenues that are presently favoured by the wider academic (risk) community. The final section of the paper provides research ideas regarding what academics working in the food risk communication area may wish to look at now. Among the issues highlighted include addressing the issue of media amplification, rebuilding public trust, and better communicating uncertainty.