Miracle-dz/UniFAR-FTUs huggingface dataset:
Distortion Product Otoacoustic Emission Levels and Input/Output-Growth Functions in Normal-Hearing Individuals with Tinnitus and/or Hyperacusis

The purpose of this study was to determine whether distortion product otoacoustic emissions (DPOAEs) can be used to distinguish among four groups with audiometrically normal-hearing sensitivity: (1) control adults without tinnitus or hyperacusis, (2) patients with tinnitus alone, (3) patients with hyperacusis alone, and (4) patients with both tinnitus and hyperacusis. Two types of DPOAE measures were evaluated: (1) the distortion product- (DP-) gram measured with fixed primary levels as a function of frequency, and (2) DPOAE input/output (I/O) functions for a range of primary levels between 45 and 70 dB sound pressure level (SPL) at 1000, 2000, and 4000 Hz. DP-grams did not clearly distinguish between the control and patient groups. There was, however, a consistent trend for the three patient groups to have decreased average DP levels at 4000 and 6000 Hz; this notch in the DP-gram was not observed in the response configuration for the control group. In the three patient groups, 51 to 74% of these individuals had DP levels that were outside of the 95% confidence range for the control group. The average slopes of the I/O growth functions for each of the patient groups were consistently steeper than those for the control group; however, the slope values were indistinguishable among the patient groups. About 60% of the patients' DPOAE responses (in each group) were categorized as abnormal based on their slope values. Thus, DPOAE measures can be used with at least partial success to distinguish controls from patients with tinnitus, hyperacusis, or both tinnitus and hyperacusis, but not to discriminate among the respective patient groups. These findings suggest that the pathology represented among the patient groups is consistent at the level of the cochlea; however, diagnostic tests targeted at higher centers of processing are needed if the individuals in these groups are to be distinguished among themselves.
A prospective, controlled study assessing the effect of lopinavir on amprenavir concentrations boosted by ritonavir

In a controlled, prospective study, the efficacy of ritonavir 200 mg twice daily (bid) in inhibiting the decrease of amprenavir plasma concentrations caused by co‐administration of lopinavir was assessed. Twelve HIV‐seropositive patients were enrolled, and nine patients completed the 28‐day study. At day 14, plasma concentrations of amprenavir 600 mg bid and ritonavir 200 mg bid were determined over 12 h. At day 15, lopinavir 400 mg bid was added. At day 28, plasma concentrations of amprenavir, ritonavir and lopinavir were assessed. Co‐administration of lopinavir was found to decrease the amprenavir concentration, determined as the median area under the curve over 12 h (AUC12), by 25% (AUC12 24.9 μg/h/mL vs. 18.5 μg/h/mL; P<0.01), despite the presence of ritonavir 200 mg bid. Eight participants discontinued the study regimen during the first 6 weeks because of adverse gastrointestinal events. In conclusion, gastrointestinal tolerance of a regimen containing an increased dose of ritonavir 200 mg bid was low, while the regimen did not prevent a decrease of amprenavir and possibly lopinavir plasma concentrations.
Approaches to Display of Ultra-resolution Video Streaming by Multi-transmission on Tiled Display Environment

In order to realize advanced remote communication via WAN, we consider that non-verbal communication play an important role, and displaying the existence of participant in remote sites with the large-scale screen by transmission of high-quality video streaming is effective. In past research, we have constructed tele-immersive environment with tiled display wall to realize realistic remote communication. However, the video image captured by a single small camera is difficult to display as video streaming with realistic high-resolution on tiled display wall, because there is a limit in the display resolution of video image captured by a single camera. In this paper, we have constructed the remote communication environment with tiled display wall, and have tried to display ultra resolution video streaming on tiled display wall by transmitting each video image which captured by four cameras in order to study the possibility of realistic remote communication. From experimental results, we could display more high-quality than expanded video image by a single camera. Therefore, we showed to have the feasibility of realistic remote communication by display of ultra-resolution video streaming on tiled display wall by multi-transmission video.
Faecal enterococci from camels in Tunisia: species, antibiotic resistance and virulent genes

The involvement of the adrenal gland in short- and long-term adaptation of organisms to stress-inducing agents is known. A number of studies have shown that anaesthetics might regulate these systems and, consequently, influence serum glucocorticoid concentrations in rabbits (Gonzalez Gil and others 2001). In order to assess the cortico-adrenal response to different anaesthetics mixtures in rabbits, 10 New Zealand White rabbits maintained under conventional conditions (12/12 light/dark, 20–22°C, 50–55 per cent relative humidity, 10–15 air changes/hour), were assigned to four treatment groups (n = 10/group). The experimental protocols adhered to the Council of EU (European Union) rules, and were approved by the Institutional Animal Care and Use Committee of the Veterinary Faculty of Madrid at Universidad Complutense of Madrid, Spain. Treatment order was randomised, and each animal received all treatments with a minimum interexperiment interval of 10 days. The groups were: control group (C), 1 ml normal saline solution; group K/F, ketamine (25 mg kg−1, Imalgene 1000, Merial, Barcelona, Spain) and fentanyl (0.02 mg kg−1, Fentanest, Kern Pharma, Barcelona, Spain); group F/M, fentanyl (0.02 mg kg−1) and medetomidine (0.2 mg kg−1, Domtor, Pfizer, Madrid, Spain); and group F/M/D, fentanyl (0.02 mg kg−1), medetomidine (0.2 mg kg−1) and diazepam (1 mg kg−1, Valium, Roche Farma, Madrid, Spain). The dosages were based upon preliminary studies and from a review of previous anaesthetics studies using rabbits (Baumgartner and others 2010). In order to minimise …
Single-photon-counting hotspot detector with integrated RSFQ readout electronics

Absorption of an infrared photon in an ultrathin film (such as 10-nm NbN) creates a localized nonequilibrium hotspot on the submicron length scale and sub-ns time scale. If a strip /spl sim/1 /spl mu/m wide is biased in the middle of the superconducting transition, this hotspot will lead to a resistance pulse with amplitude proportional to the energy of the incident photon. This resistance pulse, in turn, can be converted to a current pulse and inductively coupled to a SQUID amplifier with a digitized output, operating at 4 K or above. A preliminary design analysis indicates that this data can be processed on-chip, using ultrafast RSFQ digital circuits, to obtain a sensitive infrared detector for wavelengths up to 10 /spl mu/m and beyond, with bandwidth of 1 GHz, that counts individual photons and measures their energy with 25 meV resolution. This proposed device combines the speed of a hot-electron bolometer with the single-photon-counting ability of a transition-edge microcalorimeter, to obtain an infrared detector with sensitivity, speed, and spectral selectivity that are unmatched by any alternative technology.
EZH2 mutations and their association with PICALM‐MLLT10 positive acute leukaemia

results from the MOLI-SANI project. Haematologica, 96, 1180–1188. Siervo, M. , Ruggiero, D. , Sorice, R. , Nutile, T. , Aversano, M. , Stephan, B.C. & Ciullo, M. (2010) Angiogenesis and biomarkers of cardiovascular risk in adults with metabolic syndrome. Journal of Internal Medicine, 268, 338–347. Soranzo, N. , Spector, T.D. , Mangino, M. , Kuhnel, B. , Rendon, A. , Teumer, A. , Willenborg, C. , Wright, B. , Chen, L. , Li, M. , Salo, P., Voight, B.F. , Burns, P., Laskowski, R.A. , Xue, Y. , Menzel, S. , Altshuler, D. , Bradley, J.R. , Bumpstead, S. , Burnett, M.S., Devaney, J., Doring, A. , Elosua, R. , Epstein, S.E. , Erber, W. , Falchi, M. , Garner, S.F. , Ghori, M.J., Goodall, A.H. , Gwilliam, R. , Hakonarson, H.H. , Hall, A.S. , Hammond, N. , Hengstenberg, C. , Illig, T. , Konig, I.R. , Knouff, C.W. , McPherson, R. , Melander, O. , Mooser, V. , Nauck, M. , Nieminen, M.S., O’Donnell, C.J., Peltonen, L. , Potter, S.C. , Prokisch, H. , Rader, D.J., Rice, C.M. , Roberts, R. , Salomaa, V. , Sambrook, J., Schreiber, S. , Schunkert, H. , Schwartz, S.M. , Serbanovic-Canic, J., Sinisalo, J., Siscovick, D.S. , Stark, K. , Surakka, I. , Stephens, J., Thompson, J.R. , Volker, U. , Volzke, H. , Watkins, N.A. , Wells, G.A. , Wichmann, H.E. , Van Heel, D.A. , Tyler-Smith, C. , Thein, S.L. , Kathiresan, S. , Perola, M. , Reilly, M.P., Stewart, A.F. , Erdmann, J., Samani, N.J., Meisinger, C. , Greinacher, A. , Deloukas, P., Ouwehand, W.H. & Gieger, C. (2009) A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nature Genetics, 41, 1182–1190. Stasi, R. , Amadori, S. , Osborn, J., Newland, A.C. & Provan, D. (2006) Long-term outcome of otherwise healthy individuals with incidentally discovered borderline thrombocytopenia. PLoS Med, 3, e24. Tepper, B.J., Koelliker, Y. , Zhao, L. , Ullrich, N.V. , Lanzara, C. , d’Adamo, P., Ferrara, A. , Ulivi, S. , Esposito, L. & Gasparini, P. (2008) Variation in the bitter-taste receptor gene TAS2R38, and adiposity in a genetically isolated population in Southern Italy. Obesity (Silver Spring), 16, 2289– 2295. Traglia, M. , Sala, C. , Masciullo, C. , Cverhova, V. , Lori, F. , Pistis, G. , Bione, S. , Gasparini, P., Ulivi, S. , Ciullo, M. , Nutile, T. , Bosi, E. , Sirtori, M. , Mignogna, G. , Rubinacci, A. , Buetti, I. , Camaschella, C. , Petretto, E. & Toniolo, D. (2009) Heritability and demographic analyses in the large isolated population of Val Borbera suggest advantages in mapping complex traits genes. PLoS ONE, 4, e7554.
Modelling software quality costs by adapting established methodologies of mature industries

In the software sector, the calculation and modelling of quality costs have not achieved the maturity of other industries yet. In this paper, a model that bridges the gap between classic cost accounting and software development specific models is proposed. This model considers defect introduction and removal, and can be applied to different granularities. An implementation plan is suggested for its instantiation and explained exemplarily by a commonly used software quality model.
Leadership : A Critical Perspective

The Problem This paper considers concepts of toxic and bad leadership from a critical, poststructuralist perspective and illustrates how this can be conveyed to management students through the use of film analysis. In response to the paucity of critical approaches within toxic and bad leadership studies, we suggest that film is a useful way of developing in-depth discussion in student and management groups to uncover underlying subtleties and complexity in leadership theory and practice. The Solution We connect to film clips from Batman: the Dark Knight, and explain how this film is used with students and managers to illustrate the ambiguous nature of ‘good’ and ‘bad’ leadership and explore the fluid, shifting and relational nature of these two concepts. We conclude that students and managers can recognise this more readily through viewing, discussing and analysing film clips such as the ones discussed herein. Stakeholders – university lecturers and students, executive educators and managers, general HRD professionals
Visual Hallucinations and Amyloid Deposition in Parkinson's Disease Dementia: A Case Report

Parkinson's disease dementia (PDD) is notorious for its debilitating clinical course and high mortality rates. Consequently, various attempts to investigate predictors of cognitive decline in Parkinson's disease (PD) have been made. Here we report a case of a 75-year-old female patient with PD who visited the clinic with complaints of recurrent visual hallucinations and cognitive decline, whose symptoms were ameliorated by the titration of rivastigmine. Imaging results showed pronounced diffuse cortical amyloid deposition evidenced by 18F-florbetaben amyloid positron emission tomography (PET) imaging. This observation suggests that pronounced amyloid deposition and visual hallucinations in PD patients could be clinically significant predictors of cognitive decline in PD patients. Future research should concentrate on accumulating more evidence for possible predictors of cognitive decline and their association with PD pathology that can enable an early intervention and standardized treatment in PDD patients.
Hypoglycemic and Hypolipidemic Effect of Seed Hydromethanolic Extract of Tamarindus indica L. on Streptozotocin-Induced Diabetes Mellitus in Rat

Objectives: The present available drugs for diabetes management by insulin or oral hypoglycemic agents have one or more adverse effects. Search for new hypoglycemic drugs from herbal plants parts without or a minimum adverse effect is a challenges. Present study was aimed to evaluate the antidiabetic and antihyperlipidemic effect of hydromethanolic extract of seed of Tamarindus indica L covering the biochemical parameters for the management of streptozotocin-induced diabetic rat. Methods: Forty matured Wistar strain male albino rats, fasting blood glucose level 75±5 mg/dl and weighing 135±10 g were selected for this experiment. They were divided into four groups. Diabetes was induced by intramuscular injection of streptozotocin. Fasting blood sugar level was monitored by glucometer. Hydromethanolic extract (1:1) of seed of Tamarindus indica was administered at the dose of 80 mg/100 g body weight/day by gavage for 14 days to diabetic rats. Serum was separated and used for total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDLc), low density lipoprotein cholesterol (LDLc), very low density lipoprotein cholesterol (VLDLc) and also subjected to used for ELISA method for insulin assay. Activities of hepatic and renal biomarker enzymes were measured. The statistical analysis of the results was carried out using ANOVA followed by multiple two tail t test. Results: Diabetic rats showed elevated blood glucose level and significant diminution in the activities of hexokinase activity in liver. Administration of hydromethanolic extract of Tamarindus indica seed to diabetic rats resulted a significant recovery of above mentioned parameters (P<0.05) side by side serum insulin level, glycogen content in liver and skeletal muscle, along with diabetic dyslipidemia was protected in comparison to diabetic rats. Active biomolecule(s) present of this seed extract revealed the presence of flavonoids and total phenolic compounds. There was a significant diminution in the activities of hepatic and renal function biomarkers in diabetic rats treated with seed extract compared to only diabetic rats indicating the non toxic properties of this said extract against liver and kidney damage. Conclusion: It is concluded that the hydromethanolic extract of T. indica seed is capable of managing hyperglycemia, anti-hyperlipidemia and diabetes related complications. Hence this extract may be considered as one of the potential source for the isolation of new oral hypoglycemic drugs.
Prolonged exposure therapy: past, present, and future

Edna B. Foa, Ph.D., is a professor of Clinical Psychology in Psychiatry at the University of Pennsylvania and Director of the Center for the Treatment and Study of Anxiety. Dr. Foa devoted her academic career to study the psychopathology and treatment of anxiety disorders, primarily obsessive–compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). Her research, aimed at delineating theoretical frameworks, targeted treatments, and treatment mechanisms of pathological anxiety has been highly influential. She is currently one of the leading experts in the areas of PTSD OCD. The treatment program she has developed for PTSD sufferers has received the most evidence for its efficacy and has been disseminated in the United States and around the world. Dr. Foa has published 18 books and more than 350 articles and book chapters and has lectured extensively around the world. Her work has been recognized with numerous awards and honors, among them the Distinguished Scientific Contributions to Clinical Psychology Award from the American Psychological Association; Lifetime Achievement Award presented by the International Society for Traumatic Stress Studies; Lifetime Achievement Award presented by the Association for Behavior and Cognitive Therapies; TIME 100 most influential people of the world; 2010 Lifetime Achievement in the Field of Trauma Psychology Award from the American Psychological Association; and the Inaugural International Obsessive–Compulsive Disorder Foundation Outstanding Career Achievement Award.
An enhanced spatial reasoning ontology for maritime anomaly detection

Although originally conceived as a conceptual object for modelling knowledge, current ontologies do not make it possible to manipulate spatial knowledge. However, spatial knowledge is an essential component of any modelling specification. This problem provided the motivation for the creation of an expert system driven by an ontology. The system enables experts in the maritime domain to characterise abnormal ship behaviour based on formal semantic properties. Users are able to specify and execute spatial rules that are directly integrated into the ontology and a map interface linked to the ontology displays the results of the inferences obtained.
Cognitive deficits associated with optic aphasia: Neuropsychological contribution to a differential diagnosis

Optic aphasia is characterized by a deficit in naming objects presented visually, as a result of left occipito-temporal lesion. It differs from other neuropsychological disorders due to the nature of the deficits and impairment of cognitive function. A 52 year-old patient, admitted after an episode of sub-acute infarction in the territory of the left posterior cerebral artery involving the temporo-occipital region, was submitted to neuropsychological evaluation as part of a diagnostic investigation and presented specific characteristics of this disorder, as well as impairment to episodic memory. The relevance of the present case is justified not only due to the rarity of the disorder, but also because it highlights the importance of differential diagnosis in the treatment of patients.
Entwicklungen und Herausforderungen rund um die ergotherapeutische Fachsprache im deutschen Sprachraum: Wie stehts um Betätigung?

Abstract Der Artikel gibt einen Überblick über die Entwicklung der ergotherapeutischen Fachsprache seit der Einführung der Begriffe Betätigung und Handlung als mögliche Bezeichnungen für das Konzept Occupation vor 15 Jahren. Die Begriffe sind mittlerweile in der Literatur als Fachbegriffe fest verankert. Als Problem stellt sich jedoch die inkonsequente Verwendung der beiden Begriffe dar, deren zögerliche Akzeptanz in der Praxis sowie die unscharfe Trennung zu Begriffen rund um das Tun. Die große Herausforderung besteht in der inhaltlichen Klärung des Konzeptes Betätigung und der damit möglichen Abgrenzung zum Konzept der Aktivität. Projekte aus dem deutschsprachigen Raum werden beschrieben, die auf einen einheitlichen Sprachgebrauch abzielen. Der Prozess der inhaltlichen Klärung des Konzeptes Betätigung wird im Kontext des professionellen Reasonings und der möglichen Auswirkungen auf die ergotherapeutische Forschung beschrieben. Ein vermehrtes Bewusstsein über die Herausforderungen rund um die deutsche Fachterminologie könnte zur internationalen Diskussion über Fachterminologie beitragen.
Phenomenology of the Scream

We will begin with a single remarkable scream or, at any rate, with the literary description of one. This scream is emitted in the second canto of Comte de Lautréamont’s Maldoror. The narrator, like a perverse St. John, has a vision of an anthropophagic god, his feet immersed in a “vast pool of boiling blood, to whose surface two or three cautious heads would suddenly rise like tapeworms from a full chamberpot,” in reserve for the god’s next course. Maldoror is paralyzed with horror until, “my tight chest unable to exhale the lifegiving air quickly enough, my lips parted and I cried out . a cry so earsplitting . that I heard it! ”1—a fact remarkable only because the narrator has been deaf from birth. Now this medical miracle is of less interest to me than what is said about this scream, and screams in general, by Douglas Kahn in his history of sound in the arts, Noise, Water, Meat. He writes of Maldoror:
A Column Generation Algorithm for a Rich Vehicle-Routing Problem

We present an optimization algorithm developed for a provider of software-planning tools for distribution logistics companies. The algorithm computes a daily plan for a heterogeneous fleet of vehicles that depart from different depots and must visit a set of customers for delivery operations. In this rich vehicle-routing problem (VRP), we consider multiple capacities; time windows associated with depots and customers; incompatibility constraints between goods, depots, vehicles, and customers; maximum route length and duration; upper limits on the number of consecutive driving hours and compulsory drivers' rest periods; the possibility of skipping some customers and using express courier services instead of the given fleet to fulfill some orders; the option of splitting up the orders; and the possibility of open routes that do not terminate at depots. Moreover, the cost of each vehicle route is computed through a system of fees depending on the locations visited by the vehicle, the distance traveled, the vehicle load, and the number of stops along the route. We developed a column generation algorithm where the pricing problem is a particular resource-constrained elementary shortest-path problem, solved through a bounded bidirectional dynamic programming algorithm. We describe how to encode the cost function and the complicating constraints by an appropriate use of resources, and we present computational results on real instances obtained from the software company.
CLUSTERS COMERCIAIS: UM ESTUDO SOBRE CONCENTRAÇÕES DE BARES NA CIDADE DE SÃO PAULO

O presente trabalho resultou do estudo da adequacao da abordagem de clusters de negocios para operacoes varejistas concentradas geograficamente em centros urbanos. Examinou-se o desempenho de bares em Sao Paulo, presentes em concentracoes e externas a elas. Indicadores, associados as condicoes de operacao examinadas, foram analisados segundo modelo de Zaccarelli et. al. (2008), buscando-se a verificacao e a compreensao das potenciais diferencas, preconizadas pelo modelo. O metodo empregado na pesquisa consistiu de etapa quantitativa, com entrevistas baseadas em questionario, envolvendo responsaveis por bares na Vila Madalena, na Vila Olimpia e em localizacoes isoladas, e de etapa qualitativa, na qual, por meio de entrevistas semi-estruturadas, foram coletadas informacoes de gestores de bares. As diferencas identificadas sugerem consistentemente relacao com localizacao dos bares, entretanto, as informacoes obtidas nao caracterizaram suficientemente as concentracoes como clusters, embora, a de Vila Madalena ofereca indicios vigorosos da presenca de atributos caracteristicos de cluster de negocios. Palavras-chave : clusters de negocios, rede de negocios, APL, competitividade de clusters de negocios.