Miracle-dz/UniFAR-FTUs huggingface dataset:
An upper-level functional design ontology to support knowledge management in SME-based E-Manufacturing of mechanical products

Abstract This paper presents a conceptual and computational framework for supporting the development of knowledge management systems based on ontology design and implementation. This framework supports enterprises involved in the design and manufacturing of complex mechanical products: in particular, we focus our attention on a network of small/medium Italian enterprises that collaborates in the production of a supermotard bike called Terra Modena 198. Starting from some theoretical considerations about the role of ontologies in engineering design, this paper reflects on the difficulties that arise when knowledge is distributed, and misunderstanding and communication problems among partners could easily lead to errors in the final product.
Exploiting personal web servers for mobile context-aware applications

Abstract There is an increasing trend in moving desktop applications to web browsers, even when the web server is running on the same desktop machine. In this paper, we go further in this direction and show how to combine a web server, a web application framework (enhanced to support desktop-like Model–View–Controller interaction) and a context-aware architecture to develop web-based mobile context-aware applications. By using this approach we take advantage of the well-established web paradigm to design the graphical user interfaces (GUIs) and the inherent ability of the web to mash up applications with external components (such as Google Maps). On top of that, since the web server runs on the device itself, the application can access local resources (such as disk space or sensing devices, which are indispensable for context-aware systems) avoiding the sandbox model of the web browsers. To illustrate our approach we show how a mobile hypermedia system has been built on top of our platform.
High expression of Wls is associated with lymph node metastasis and advanced TNM stage in gastric carcinomas

The roles of Wnt protein in carcinogenesis have been well documented in human cancers. Wls is a key modulator for the secretion of Wnt protein. We previously found that Wls was aberrantly expressed in colorectal carcinomas. Studies have revealed that dysregulation of Wnt signal transduction plays an important role in gastric carcinoma. We hypothesized that Wls may play a role in the development and progression of gastric carcinoma. In this study, three gastric cancer cell lines MGC‐803, SGC‐7901, and AGS, and a set of gastric carcinoma tissue specimens were subjected to immunohistochemistry. The relationship between the expression of Wls and clinicopathological parameters was analyzed. Wls was negatively detected in MGC‐803, positively detected in SGC‐7901 and AGS cell lines. Wls was weakly expressed in 9.7% (15/154), moderately in 33.1% (51/154), and strongly in 57.1% (88/154) of tested gastric carcinoma specimens. High expression of Wls was positively associated with well and moderately differentiated tumors (P = 0.035, rs = 0.170), lymph node metastasis (P = 0.001, rs = 0.276), and advanced TNM stage (P = 0.006, rs = 0.219). Our data suggest that Wls protein is related to tumor metastasis and advanced TNM stage, and may be used as a new marker for prognosis of gastric carcinoma.
Efficient modification of the myostatin gene in porcine somatic cells and generation of knockout piglets

Myostatin (MSTN) is a negative regulator of myogenesis, and disruption of its function causes increased muscle mass in various species. Here, we report the generation of MSTN‐knockout (KO) pigs using genome editing technology combined with somatic‐cell nuclear transfer (SCNT). Transcription activator‐like effector nuclease (TALEN) with non‐repeat‐variable di‐residue variations, called Platinum TALEN, was highly efficient in modifying genes in porcine somatic cells, which were then used for SCNT to create MSTN KO piglets. These piglets exhibited a double‐muscled phenotype, possessing a higher body weight and longissimus muscle mass measuring 170% that of wild‐type piglets, with double the number of muscle fibers. These results demonstrate that loss of MSTN increases muscle mass in pigs, which may help increase pork production for consumption in the future. Mol. Reprod. Dev. 83: 61–70, 2016. © 2015 Wiley Periodicals, Inc.
Epigenetic imprinting during assisted reproductive technologies: The effect of temporal and cumulative fluctuations in methionine cycling on the DNA methylation state

Assisted reproductive technology (ART) exposes gametes and embryos to an artificial environment that does not resemble the conditions of natural conception, and therefore might change epigenetic regulation of genes that are imprinted during development. In the present review, we discuss the relationship between susceptibility of specific genes to receive an altered epigenetic composition during ART processes, possibly via alterations in the biochemical folate and methionine cycle. We provide a comprehensive view of the current state of epigenetic patterning in ART‐conceived healthy children and in Angelman syndrome (AS) and Beckwith–Wiedemann syndrome (BWS) patients. We illustrate that similar genes—that is, MEST, KCNQ1OT1, and IGF2—possess an altered DNA methylation profile in animal models, ART‐conceived healthy children, and AS and BWS patients. The developmental stage at which these genes receive their epigenetic imprint appears to coincide with the specific moment that ART takes place. We highlight that ART procedures affect physiological levels of enzymes and substrates involved in the folate and methionine cycle thereby altering the DNA methylation state. Moreover, although the DNA methylation rate appears to be robust: (i) temporal imbalances coinciding with defined moments of epigenetic imprinting of specific genes affect the eventual DNA methylation state of those genes and (ii) cumulative ART effects on methionine and folate cycling can alter DNA methylation rates. These observations underscore the necessity to further investigate consequences of ART treatments on the epigenetic profile. Mol. Reprod. Dev. 83: 94–107, 2016. © 2015 Wiley Periodicals, Inc.
Growth stimulation in inflorescences of an Arabidopsis tubulin mutant under microgravity conditions in space.

Cortical microtubules are involved in plant resistance to hypergravity, but their roles in resistance to 1 g gravity are still uncertain. To clarify this point, we cultivated an Arabidopsis α-tubulin 6 mutant (tua6) in the Cell Biology Experiment Facility on the Kibo Module of the International Space Station, and analyzed growth and cell wall mechanical properties of inflorescences. Growth of inflorescence stems was stimulated under microgravity conditions, as compared with ground and on-orbit 1 g conditions. The stems were 10-45% longer and their growth rate 15-55% higher under microgravity conditions than those under both 1 g conditions. The degree of growth stimulation tended to be higher in the tua6 mutant than the wild-type Columbia. Under microgravity conditions, the cell wall extensibility in elongating regions of inflorescences was significantly higher than the controls, suggesting that growth stimulation was caused by cell wall modifications. No clear differences were detected in any growth or cell wall property between ground and on-orbit 1 g controls. These results support the hypothesis that cortical microtubules generally play an important role in plant resistance to the gravitational force.
The poverty of the Mayan stimulus*

ABSTRACT Poverty of the stimulus (POS) arguments have instigated considerable debate in the recent linguistics literature. This article uses the comparative method to challenge the logic of POS arguments. Rather than question the premises of POS arguments, the article demonstrates how POS arguments for individual languages lead to a reductio ad absurdum as POS arguments from genetically related languages are compared. Comparison leads to different contradictions for poverty of the negative stimulus (PONS) and poverty of the positive stimulus (POPS) arguments. Comparing PONS arguments leads to the conclusion that Universal Grammar contains language-specific versions of linguistic rules. Comparing POPS arguments leads to the conclusion that Universal Grammar may supply knowledge that is ungrammatical in the target language. The reductio shows that universal principles of grammar cannot be established on the basis of POS arguments from a single language.
Text messaging in healthcare: the elephant knocking at the door.

Introduction n discussions of telemedicine modalities, text messaging, also more technically referred to as SMS for Short Message Service, isn’t the elephant in the room, the one everybody’s ignoring and afraid to talk about. Text messaging is the elephant at the door, the one everybody knows is trying to get into the room, but nobody’s quite sure how it’ll fit through the door, how big it is, or what exactly they’re going to do with it once it gets through. Comparatively, the U.S. is behind the rest of the world in terms of text messaging. Research company SNL Kagan (Charlottesville, VA) released a report in 2007 estimating that 84% of the U.S. population—including consumers, business users and people with multiple units—would have mobile phones by the end of 2007, which would surpass 100% by 2013. Yes, that’s ‘surpass’ 100% due to the number of multiple unit owners. Informa Telecoms and Media (London, UK) reported in 2006 that thirty countries had exceeded 100% cell phone penetration in that year. It is further estimated that 50% of the global population currently owns a mobile phone and 98% of those phones have text messaging capabilities. Here’s one more statistic to further drive home the growth of text messaging: According to messaging services provider Acision (Nieuwegein, Netherlands), on New Year’s Day, January 1, 2008, 43 billion text messages were sent globally.
First language development: a usage-based perspective on past and current research*

ABSTRACT I first outline three major developments in child language research over the past forty years: the use of computational modelling to reveal the structure of information in the input; the focus on quantifying productivity and abstraction; and developments in the explanation of systematic errors. Next, I turn to what I consider to be major outstanding issues: how the network of constructions builds up and the relationship between social and cognitive development and language learning. Finally, I briefly consider a number of other areas of importance to a psychologically realistic understanding of children's language development.
Underlying manifestations of developmental phonological disorders in French-speaking pre-schoolers*

Abstract This study examined the psycholinguistic profiles of Quebec French-speaking children with developmental phonological disorders (DPD). The purpose was to determine whether the endophenotypes that have been identified in English-speaking children with DPD are similarly associated with speech impairment in French-speaking children. Seventy-two children with DPD and ten children with normally developing speech, aged four to six years, received a comprehensive assessment battery that included measures at the phenotype level (i.e. measures of overt speech production skills) and endophenotype level (i.e. measures of potential underlying core deficits such as phonological processing or oral motor impairments). The majority of the children with DPD presented with a psycholinguistic profile indicative of difficulties with phonological processing. Phonological processing skills also explained unique variance in speech production accuracy, indicating that French-speaking children with DPD, who produce different surface speech errors than English-speaking children with DPD, are nonetheless very similar with regards to their underlying psycholinguistic profile.
Maternal verbal responsiveness and directiveness: consistency, stability, and relations to child early linguistic development*

Abstract Maternal responsive and directive speech to children at ages 0;10 and 2;0 was investigated by applying a procedure first introduced by Flynn and Masur (2007) to a new language community (Finnish). The issues examined were consistency and stability over time, and also the role of responsiveness and directiveness in child linguistic development at 1;0 and 2;6. The measures of maternal speech from each age were used to predict the results of the subsequent linguistic assessment. Negative correlations between responsive and directive utterances were found at both ages. The frequencies of responsive utterances and supportive directives increased over time. Responsiveness was positively, and intrusive directiveness negatively, related to child early comprehensive skills and the use of symbolic actions and communicative gestures. By contrast, no relations were found between responsiveness and directiveness and children's later linguistic capacities.
Theory and generalization of monte carlo models of the BOLD signal source

The dependency of the blood oxygenation level dependent (BOLD) signal on underlying hemodynamics is not well understood. Building a forward biophysical model of this relationship is important for the quantitative estimation of the hemodynamic changes and neural activity underlying functional magnetic resonance imaging (fMRI) signals. We have developed a general model of the BOLD signal which can model both intra‐ and extravascular signals for an arbitrary tissue model across a wide range of imaging parameters. The model of the BOLD signal was instantiated as a look‐up‐table (LuT), and was verified against concurrent fMRI and optical imaging measurements of activation induced hemodynamics. Magn Reson Med, 2008. © 2008 Wiley‐Liss, Inc.
Exploring Women’s Attitudes and Intentions to Seek Care from Nurse Practitioners across Different Age Groups

RÉSUMÉ Puisque l’acceptation publique est essentielle à une intégration réussie des infirmières praticiennes dans le système de soins de santé canadien, la présente étude examine de quelle manière les femmes de différents groupes d’âge perçoivent les infirmières praticiennes. Les femmes d’âge moyen avaient généralement une opinion plus positive des professionnels de la santé et étaient plus enclines à indiquer qu’elles demanderaient de l’aide des infirmières praticiennes que les femmes plus âgées et plus jeunes qu’elles. Les répondants des trois groupes d’âge étaient davantage portés à consulter des médecins que des infirmières praticiennes, particulièrement en ce qui concerne les problèmes de santé aigus (par opposition aux questions préventives). ABSTRACT Because public acceptance is critical for the successful integration of nurse practitioners into the Canadian health care system, the current study explored how women of different ages perceive nurse practitioners. Middle-aged women held more positive views of health care professionals in general and were more likely to indicate that they would seek help from nurse practitioners compared to younger and older women. Across all three age groups, respondents were more likely to seek help from physicians than from nurse practitioners, especially for acute (versus preventive) health concerns.
CONCERNING THE NATURE OF PROTOZOAN-LIKE CELLS IN CERTAIN LESIONS OF INFANCY

The so-called "protozoan-like" cells with which this paper is concerned were first described in 1904 by Jesionek and Kiolemenoglou,1who found them in the kidneys, lungs and liver of an eight months fetus, in intimate association with lesions of hereditary syphilis. The authors pictured these extraordinary structures as measuring on an average from 20 to 30 microns in diameter, usually oval in outline, possessing a well defined, though not sharply stained, cuticular zone having the appearance of a capsule. The nuclei were large, eccentrically placed, each containing a very pronounced "central nuclear body" surrounded by two well defined zones, an inner dark and an outer clear zone. The entire nucleus appeared separated from the cell body by a membrane. In the clear outer zone of the nucleus were found spherical, darkly staining granules of different sizes averaging 1 micron. The width of the nucleus, inclusive of the membrane, measured
The role of teachers in sex education and the prevention and control of HIV/AIDS in Nigeria

Research was undertaken to assess the role of primary school teachers with regard to the prevention and control of HIV/AIDS in Nigeria. Structured and semi‐structured questionnaires were responded to by 210 teachers drawn from primary schools in Eastern Nigeria (with pupils aged 6–15 years). These were supplemented by focus group discussions and key informant interviews. The findings show that the teachers have a reasonably high knowledge of the modes of HIV transmission, the behavioural risk factors and modes of prevention. The teachers, however, are reluctant to teach this because of socio‐cultural and religious factors, lack of teacher training in delivery of sex education as well as poor motivation. The motivation and participation of primary school teachers in the prevention of HIV in Nigeria are very low. This calls for serious and urgent policy intervention to remedy the situation and increase the role of primary school teachers in combating the spread of HIV/AIDS in Nigeria.
Brassica napusGLABRA3-1 promotes anthocyanin biosynthesis and trichome formation in true leaves when expressed in Arabidopsis thaliana.

Previous studies have shown that GLABRA3 (AtGL3), a bHLH transcription factor, plays essential roles in anthocyanin biosynthesis and trichome formation in Arabidopsis thaliana. However, there have been no such studies of a homologue, BnGL3, from the closely related crop, Brassica napus. Here, we analysed the BnGL3-1 coding domain sequence from the B. napus cultivar QINYOU Seven, identified conserved protein domains and performed a phylogenetic analysis to elucidate its relationship with homologues form a range of plant species. When expressed in tobacco leaves as a fusion protein with green fluorescent protein, BnGL3-1 accumulated in the nucleus, consistent with its predicted function as a transcription factor. Ectopic expression of the BnGL3-1 gene in the A. thaliana gl3-3 mutant resulted in levels of anthocyanins and numbers of trichomes in true leaves that were higher than in wild-type plants. Moreover, overexpression of BnGL3-1 in gl3-3 compensated for the promotion and repression of genes involved in anthocyanin biosynthesis and trichome formation, respectively, that has been reported in gl3-3 young shoots and expanding true leaves. This study provides new insights into GL3 function in anthocyanin biosynthesis and trichome formation in crucifers, and represents a promising target for genetic manipulation of B. napus.
Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 1994: NSAID: AN UPDATE ON THEIR ANALGESIC EFFECTS

1. The non‐steroidal anti‐inflammatory drugs (NSAID) are a group of drugs that possess both analgesic and anti‐inflammatory properties. They are used to treat a variety of painful and inflammatory disorders such as postoperative pain, dental surgery, headache, acute and chronic musculoskeletal pain.
Tendon Transfers for the Balancing of Hind and Mid-foot Deformities in Adults and Children

Tendon transfer surgery (soft-tissue balancing) is one of the most important steps for the correction of complex foot deformities in adults and children. Often, tendon transfers are accompanied by additional bony procedures for the correction of the structural component of the foot deformity. Detailed preoperative planning (patient history, clinical examination, radiographs, dynamic pedobarography, and 3D gait and foot analysis) is considered to be necessary for the indication of the technique. The surgical technique of different tendon transfers (total split posterior tibial tendon transfer, split posterior tibial tendon transfer, spilt anterior tibial tendon transfer, posterior tibial tendon transfer, Hiroshima procedure) as a part of complex foot deformity correction is presented. Furthermore, pitfalls and complications as well as salvage strategies are discussed. The key for successful soft-tissue balancing is the consideration of the underlying pathology. The main focus is on the selection of the appropriate tendon transfers in different pathologies (eg, Charcot-Marie-Tooth disease, cerebral palsy, stroke, etc.). Bony procedures may only correct structural deformity but do not address the dynamic component of the deformity (muscular imbalance, instability, etc.). This may lead to inadequate correction and recurrence. It is therefore essential to combine bony correction with tendon transfers (soft-tissue balancing) in nearly every neurogenic foot deformity.
Subluxating Peroneal Tendon: Repair of Superior Peroneal Retinaculum Using a Retrofibular Periosteal Flap

This modification of a soft tissue reconstruction procedure for the treatment of peroneal tendon subluxation and dislocation consists of creating an anterior-based periosteal flap in the peroneal groove from the fibula. This flap is used to augment the superior peroneal retinaculum and prevent the anterior displacement of the peroneal tendons. Its multiple benefits include the augmentation of the anterior aspect of the superior peroneal retinaculum (which may be deficient) and the recreation of the normal anatomy with little disturbance of the surrounding tissue. This simple procedure, with its relative ease of reconstruction, can be performed quickly for patients with acute or chronic peroneal tendon subluxation.