Miracle-dz/UniFAR-FTUs huggingface dataset:
Intracranial venous thrombosis in a man taking clomiphene citrate

Clomiphene citrate is widely used by the female population for the management of a wide array of medical conditions especially those related to ovulation, but its use in male population remains controversial. Efficacy of clomiphene is not well established in male hypogonadism and infertility. Its side effects and complications are also poorly studied or reported. We present a case of a man with infertility issues for which he started receiving clomiphene citrate 3 weeks before presenting with progressive symptoms of headache, vomiting, transient blurred vision and diplopia, which eventually turned out to be the symptoms of intracranial venous thrombosis. After excluding the common causes of intracranial venous thrombosis and hypercoagulable state, clomiphene citrate seems the most likely culprit.
Dietary arginine supplementation speeds pulmonary VO2 kinetics during cycle exercise.

PURPOSE To test the hypothesis that L-arginine (the substrate for nitric oxide synthase [NOS]) administration slows the VO2 kinetics at the onset of moderate-intensity exercise in humans. METHODS Seven physically active males were randomly assigned to receive either placebo (lactose) or L-arginine hydrochloride capsules (7.2 g x d(-1)) for 14 d in a double-blind crossover design, with a 7-d washout period between the two conditions. On day 11 and day 14 of each condition, the subjects completed two consecutive 6-min bouts of cycle exercise at 80% of the ventilatory threshold with a 12-min rest interval. VO2 was measured on a breath-by-breath basis, and VO2 kinetics were determined with a single exponential model from the averaged data derived from four repetitions. Capillary and venous blood samples were taken to determine plasma [La] and serum [arginine], respectively. RESULTS There were no differences in circulating lactate either before or during exercise. However, serum [arginine] was higher (P < 0.05) in the arginine condition at rest (119.0 +/- 12.6 vs 103.6 +/- 15.7 micromol x L(-1) in the control condition) and after exercise (113.3 +/- 26.0 vs 103.8 +/- 12.6 micromol x L(-1) in the control condition). With regard to the pulmonary VO2 kinetics, no significant difference was observed in the time at which the phase II response emerged or in the phase II amplitude between the two conditions. However, contrary to our hypothesis, the time constant was significantly reduced after arginine administration (i.e., 13.9 +/- 3.1 vs 15.8 +/- 2.6 s in the control condition, P < or = 0.014). CONCLUSION Exogenous L-arginine administration speeds the phase II pulmonary VO2 response by 12% at the onset of moderate-intensity exercise in humans.
Variations in the inclination of the condylar path in children and adults.

OBJECTIVE To test the null hypothesis that there are no differences between children and adults in the condylar path inclination angle on the right and left sides. MATERIALS AND METHODS A group of 80 children aged 6 to 10 years (subgroups I through V, according to chronologic age) was compared with an adult group with regard to the condylar path inclination angle (CPIA) on the right and left sides. The CPIA was measured using the ultrasonic JMA-System for registration. RESULTS During development of the temporomandibular joint the condylar path inclination angle increased with age in the subgroups of children. A significant difference was found in the CPIA between the groups of adults and children. In the group with the oldest children (mean age: 10.3 years) the condylar path inclination angle had reached 81.87% on the right side and 78.85% on the left side compared with the adult group at a 5 mm protrusive path. In the pooled group of children the CPIA amounted to 73.08% on the right side and 72.13% on the left side compared with the values for the adults. No significant difference was found between the right and left CPIA in any group. CONCLUSION The hypothesis is rejected. The CPIA on the right and left sides increased with age in the group of children and was significantly smaller in the group of children compared with the group of adults.
ETUDE EN LABORATOIRE DE L'INFLUENCE DES TEMPS DE REPOS SUR LES CARACTERISTIQUES DE FATIGUE DES ENROBES BITUMINEUX

TRADUCTION DE LA COMMUNICATION PARUE DANS LE VOL 51 DES PROCEEDDINGS OF THE ASSOCIATION OF ASPHALT PAVING TECHNOLOGISTS 1982, P.104-21. LE MODULE DE RIGIDITE DES ENROBES ET LEUR RESISTANCE A LA FATIGUE SONT DES PARAMETRES IMPORTANTS QUI GOUVERNENT LA STRUCTURE DES CHAUSSEES. LES CARACTERISTIQUES EN FATIGUE DES ENROBES SONT DETERMINEES A L'AIDE D'ESSAIS QUI NE CORRESPONDENT PAS AUX CONDITIONS DE CHARGEMENT RECONTREES SOUS LE TRAFIC QUI SONT DISCONTTINUES. POUR SE FAIRE UNE OPINION PLUS PRECISE DE L'EFFET DES PERIODES DE REPOS SUR LA DUREE DE VIE EN FATIGUE DES ENROBES, ON A EFFECTUE UNE ETUDE SYSTEMATIQUE. SES RESULTATS SONT PRESENTES DANS CETTE PUBLICATION ET COMPARES AUX CONNAISSANCES ACTUELLES TIREES DE LA LITTERATURE. CES RESULTATS SONT PRESENTES AUSSI DE FACON A POUVOIR ETRE UTILISES DANS UNE METHODE DE CALCUL RATIONNEL DES CHAUSSEES. (A).
Risk of cervical cancer in women with autoimmune diseases, in relation with their use of immunosuppressants and screening: Population‐based cohort study

Severely immunosuppressed individuals have a strongly increased risk of cervical cancer. In patients with autoimmune diseases (AID), who have defects in their immune system and receive immunosuppressants, the risk of cervical cancer is less clear. We conducted a cohort study, using Danish nationwide population‐based registers including information on AID diagnoses, immunosuppressant intake, cervical screening participation, and cervical cancer incidence. Standardized incidence ratios (SIR) were computed to compare the risk of cervical cancer in AID patients to that of the general population. Hazard ratios (HR) from time‐dependent Cox models stratified by AID were used to explore the effect of the most frequently used immunosuppressants, taking into account potential dose–response relationships and lag times between drug exposure and cervical cancer development. Cervical screening coverage of patients with AIDs was compared to the general population. Among 341,758 patients with AIDs, the risk of cervical cancer was not higher than in the general population (SIR = 1.0, 95% CI: 0.9–1.1, based on 720 cases). The intake of immunosuppressants was generally not associated with the risk, apart from azathioprine. The crude HR comparing the period of exposure versus non‐exposure to azathioprine was 1.4 (95% CI: 0.9–2.1). Furthermore, the risk was substantially increased in patients who received a high cumulative dose of azathioprine (HR = 2.2, 95% CI = 1.2–3.9), and appeared to be highest when considering that the immunosuppressant exposure would take 5 years to trigger cervical cancer. Patients with AIDs had similarly high screening rates as the general population. Although most patients with AIDs do not have an increased risk of cervical cancer, those taking substantial amounts of azathioprine might need more stringent cervical screening measures.
Focus on Vastarel MR Reperfusion injury : reduction by Vastarel MR

Ischemia-reperfusion syndrome is defined as myocardial injury caused by the restoration of coronary flow. This phenomenon has a complex pathophysiology and results in a paradoxical reduction of the beneficial effect of myocardial reperfusion. Studies suggest that ischemia-reperfusion injury may account for up to 50% of the final size of a myocardial infarct. Vastarel MR (trimetazidine) is a pharmacological agent that shifts the preference for energy substrate away from fatty acid metabolism and towards glucose metabolism. Furthermore, it reduces intracellular acidosis, and protects against the toxicity induced by oxygen free radicals, which are key participants in ischemia-reperfusion injury. Accordingly, in animal studies a reduction in ischemia-reperfusion injury has been observed in association with the use of trimetazidine. These protective properties of trimetazidine over ischemia-reperfusion have also been suggested in clinical studies. Heart Metab. 2008;40:23–25.
Exact solutions of VNE: A survey

Network virtualization is an enabling technology of running multiple virtual networks on a shared substrate network. It aims to deal with the ossification of current network architecture. As a crucial component of network virtualization, virtual network embedding (VNE) can efficiently and effectively allocates the substrate resource to proposed virtual network requests. According to the optimization strategy, VNE approaches can be classified into three categories: exact, heuristic and meta-heuristic solution. The VNE exact solution is the foundation of its corresponding heuristic and meta-heuristic solutions. This paper presents a survey of existing typical VNE exact solutions, and open problems for the future research of VNE exact solutions are proposed.
Decentralized Approximate Bayesian Inference for Distributed Sensor Network

Bayesian models provide a framework for probabilistic modelling of complex datasets. Many such models are computationally demanding, especially in the presence of large datasets. In sensor network applications, statistical (Bayesian) parameter estimation usually relies on decentralized algorithms, in which both data and computation are distributed across the nodes of the network. In this paper we propose a framework for decentralized Bayesian learning using Bregman Alternating Direction Method of Multipliers (B-ADMM). We demonstrate the utility of our framework, with Mean Field Variational Bayes (MFVB) as the primitive for distributed affine structure from motion (SfM).
Optimization of Gradient Threshold Parameter inFeature Preserving Anisotropic Diffusion forImage Denoising

Image denoising emphasizes on noise removal while preserving meaningful details such as blurred thin edges and low contrast fine features. In this work, feature preservation anisotropic diffusion is proposed which not only removes noise but also has the capability of preserving fine details even of low contrast in the denoised image. This type of filtering technique is also highly dependent on some crucial parameters of filtering such as conductance function, gradient threshold parameter and stopping time. This paper also focuses on the optimization of gradient threshold parameter. The alternative options for the parameters of anisotropic diffusion at each stage of the algorithm are examined, evaluated and the best choice is selected. Experimental results evaluated on standard test images have shown that the proposed anisotropic diffusion gives better results in terms of subjective and objective measure in respect to other compared diffusion techniques.
Divergent patterns of progression to AIDS after infection from the same source: human immunodeficiency virus type 1 evolution and antiviral responses

The rate of progression to AIDS in human immunodeficiency virus type 1 (HIV-1)-infected individuals is determined by a complex series of interactions between the host and virus. Here we evaluate virologic properties and host responses in two men near-simultaneously infected with HIV-1 from the same sexual partner--one individual progressed to AIDS in less than 2 years, and the other remains asymptomatic 3 years postinfection. Distinct neutralizing antibody and cellular immune responses were evident, with the slower progressor exhibiting generally stronger and broader responses, except for cytotoxic T-lymphocyte responses early in infection. Virtually identical, homogeneous virus populations were found in both patients in the first sample obtained; however, a second unrelated HIV-1 virus population was also found in the fast progressor. Whether the second population emanated from an additional source of infection or the two were transmitted from the original source could not be determined. The virus population in the slower progressor turned over and diversified rapidly, whereas both virus populations in the rapid progressor evolved at a much slower rate. In addition, the character of mutational changes underlying these diversities appeared to be distinct, with a bias for diversifying selection developing in the slower progressor and a reciprocal bias towards purifying selection maintained in both populations in the fast progressor. Thus, the rapid evolution that is a hallmark of HIV replication may be a reflection of strong host resistance against emerging virus variants and a longer period of asymptomatic infection. Furthermore, rapid progression was not linked to a collapse of any appreciable immune response following attainment of some threshold of antigenic diversity but rather to a failure to drive this diversification and a condition of relatively unimpeded expansion of variants with optimized replicative capacity within the host.
Indexing Similar Trajectories using mvp-tree

Moving object environments contain large number of queries and continuously moving objects. The data of object trajectories in a two or three dimensional space usually contain great amount of noise. The indexing technique to for similarity queries has to be able to get the trajectories which move in similar pattern as the query though contains great amount of noise using reasonable amount of space and time. This project investigates such indexing techniques. The trajectories which contain great amount of noise can be included in the answer set as this project uses the distance function which is proposed in [1] as our distance function. The indexing scheme that we used is based on the structure of mvp-tree which helps decrease the computation time while searching because of its pre-computation during the tree construction. Furthermore, the structure of MVP-tree promotes the spherical cuts which helps pruning out the irrelevant branches during searching time works more efficiently.
Validation via Weight-of-Evidence Approaches

Early discussions on evaluating the reliability and relevance of non-animal tests for particular purposes, i.e. on their validation, focused on the performance of practical multi-laboratory studies (Balls et al., 1990, 1995). However, it subsequently became clear that such practical studies would not always be necessary or even possible, and that, in some circumstances, a weight-ofevidence approach would be more appropriate, i.e. an evaluation based on the independent collection and assessment of appropriate and sound pre-existing supporting evidence. For example, there could be evidence of sufficient volume and quality to permit an evaluation of a method which had long been in use. In other cases, there might not be in vivo benchmark data of sufficient breadth and quality to serve as acceptable reference standards for the practical evaluation of an in vitro method.
Strontium 89 for palliation of bone metastases.

At the University of Kansas Medical Center, systemic use of strontium 89 ((89)Sr), a betaemitting radioisotope, was evaluated in the treatment of metastatic carcinoma to bone for relief of bone pain. Eighty-five patients were treated with systemic (89)Sr in the dosage of 30 to 40 μCi/kg. All patients had multiple bone metastases, the majority with primary breast or prostatic cancer. The response to treatment was evaluated by daily diary entries, changes in the amount of pain medication, periodic bone scans, and other laboratory values.In the patients who survived (47) and who were observed for three or more months, overall results showed 15 percent becoming pain free; 23 percent showed marked improvement with decreased consumption of pain medication; 53 percent showed mild but significant improvement in pain relief and decrease in pain medication requirement; and 9 percent showed no improvement. No patients noted a worsening of bone pain after the treatment. There was a combined favorable response in 91 percent (43/47) of patients with some meaningful palliation after (89)Sr therapy. This study, using (89)Sr systemic therapy, suggests that this isotope may be a valuable adjuvant therapy for palliation of pain from metastatic bone lesions.
A Polymer-Based Flexible Tactile Sensor for Both Normal and Shear Load Detections and Its Application for Robotics

This paper proposes and demonstrates a novel flexible tactile sensor for both normal and shear load detections. For the realization of the sensor, polyimide and polydimethylsiloxane are used as a substrate, which makes it flexible. Thin metal strain gauges, which are incorporated into the polymer, are used for measuring normal and shear loads. The salient feature of this tactile sensor is that it has no diaphragm-like structures. The unit tactile cell characteristics are evaluated against normal and shear loads. The fabricated tactile sensor can measure normal loads of up to 4 N, and the sensor output signals are saturated against loads of more than 4 N. Shear loads can be detected by different voltage drops in strain gauges. The device has no fragile structures; therefore, it can be used as a ground reaction force (GRF) sensor for balance control in humanoid robots. Four tactile unit sensors are assembled and placed in the four corners of the robots sole. By increasing bump dimensions, the tactile unit sensor can measure loads of up to 2 kgf. When loads are exerted on the sole, the GRF can be measured by these four sensors. The measured forces can be used in the balance control of biped locomotion systems.
Highly sensitive graphene-based chemical and biological sensors with selectivity achievable through low-frequency noise measurement — Theoretical considerations

We have developed a theory of the low-frequency noise caused by interaction of the analyte with the active area of chemical and biological sensors. The main result is an analytical expression for the spectral density of the fluctuations of the number of particles adsorbed onto the sensing surface, taking into account the processes of mass transfer through the sensor reaction chamber, adsorption and desorption, and surface diffusion of adsorbed particles. The performed numerical calculations show good agreement with the experimental data from the literature, obtained for a graphene-based gas sensor. The derived theory contributes to the theoretical basis necessary for the development of a new method for the recognition and quantification of analytes, based on the measured noise spectrum.
Circulating genuine multiparty entanglement in a quantum network

We propose a deterministic scheme of generating genuine multiparty entangled states in quantum networks of arbitrary size having various geometric structures – we refer to it as entanglement circulation . The procedure involves optimization over a set of two-qubit arbitrary unitary operators and the entanglement of the initial resource state. We report that the set of unitary operators that maximize the genuine multipartite entanglement quantiﬁed via generalized geometric measure (GGM) is not unique. We prove that the GGM of the resulting state of arbitrary qubits coincides with the minimum GGM of the initial resource states. By ﬁxing the output state as the six-qubit one, we ﬁnd the optimal way to create such states according to the available resource. Moreover, we show that the method proposed here can be implemented by using logic gates, or by using the time dynamics of realizable spin Hamiltonians. In case of an ordered system, GGM varies periodically with time while the evolution via disordered models lead to a low but constant multipartite entanglement in outputs at a critical time, which decreases exponentially with the increase of the strength of the disorder.
Towards a unifying framework for demand-driven directed transport (D3T)

Decentralized autonomous systems have the potential to be more performant, resilient and sustainable than classical systems under central control. For example, this includes vehicle routing problems in logistics systems, courier services, and public transport. Here, we outline elements of a framework to model, simulate, and assess the performance of such demand-driven directed transport (D3T) systems. Our contribution is a common language based on the Discrete-Event System Specification, which facilitates modelling and performance analysis of transportation systems across domains. We expect that our approach is useful to identify universal mechanisms and to explore the intricate interplay of the transport system structure at hand and its dynamics.
The relationship between lipid peroxidation in- tensity and total antioxidant capacity in cases of spontaneously released and retained bovine placenta.

La retention des enveloppes foetales (REF) est probablement liee au stress oxydatif qui peut etre evalue par des parametres directs et indirects et notamment par la mesure de la capacite anti-oxydante totale (CAT) et celle de l'intensite de la peroxydation lipidique (IPL). Des echantillons de placentas maternels et foetaux ont ete preleves sur des vaches Holstein Frisonne a terme et saines immediatement apres cesarienne (n = 13, groupe A) ou apres velage (n = 10, groupe C) ainsi que sur des vaches presentant une retention placentaire apres la cesarienne (n = 15, groupe B) ou apres le velage (n = 8, groupe D) et la CAT et l'IPL ont ete mesurees par spectrophotometrie dans les surnageants tissulaires correspondants aux echantillons placentaires. Les vaches saines (sans REF) delivrees par cesarienne (groupe A) ont presente une CAT abaissee par rapport a celles du groupe C (p < 0.05) alors que l'lPL etait identique dans les deux groupes. Les valeurs de CAT et d'IPL ont ete nettement augmentees a la fois dans les parties maternelles et foetales du placenta chez les vaches presentant une retention placentaire (groupes B et D) (p < 0.05 par comparaison aux groupes A et C). Quelque soit le type d'accouchement et independamment de la retention placentaire, l'IPL a ete plus intense dans la partie foetale que dans la partie maternelle (p < 0.05), tandis que la CAT etait plus elevee dans le placenta maternel excepte chez les vaches velant spontanement et presentant une REF (groupe D). Ces resultats confirment l'existence d'un stress oxydatif durant la retention placentaire, particulierement dans le placenta foetal mais les relations entre processus oxydants et systemes antioxydants doivent encore etre clarifiees.
Francisella tularensis Induces Extensive Caspase-3 Activation and Apoptotic Cell Death in the Tissues of Infected Mice

ABSTRACT Although Francisella tularensis subsp. tularensis is known to cause extensive tissue necrosis, the pathogenesis of tissue injury has not been elucidated. To characterize cell death in tularemia, C57BL/6 mice were challenged by the intranasal route with type A F. tularensis, and the pathological changes in infected tissues were characterized over the next 4 days. At 3 days postinfection, well-organized inflammatory infiltrates developed in the spleen and liver following the spread of infection from the lungs. By the next day, extensive cell death, characterized by the presence of pyknotic cells containing double-strand DNA breaks, was apparent throughout these inflammatory foci. Cell death was not mediated by activated caspase-1, as has been reported for cells infected with other Francisella subspecies. Mouse macrophages and dendritic cells that had been stimulated with type A F. tularensis did not release interleukin-18 in vitro, a response that requires the activation of procaspase-1. Dying cells within type A F. tularensis-infected tissues expressed activated caspase-3 but very little activated caspase-1. When caspase-1-deficient mice were challenged with type A F. tularensis, pathological changes, including extensive cell death, were similar to those seen in infected wild-type mice. In contrast, type A F. tularensis-infected caspase-3-deficient mice showed much less death among their F4/80+ spleen cells than did infected wild-type mice, and they retained the ability to express tumor necrosis factor alpha and inducible NO synthase. These findings suggest that type A F. tularensis induces caspase-3-dependent macrophage apoptosis, resulting in the loss of potentially important innate immune responses to the pathogen.