Miracle-dz/UniFAR-FTUs huggingface dataset:
Mesenchymal Stem Cells and Their Clinical Applications in Osteoarthritis

Osteoarthritis is a chronic degenerative joint disorder characterized by articular cartilage destruction and osteophyte formation. Chondrocytes in the matrix have a relatively slow turnover rate, and the tissue itself lacks a blood supply to support repair and remodeling. Researchers have evaluated the effectiveness of stem cell therapy and tissue engineering for treating osteoarthritis. All sources of stem cells, including embryonic, induced pluripotent, fetal, and adult stem cells, have potential use in stem cell therapy, which provides a permanent biological solution. Mesenchymal stem cells (MSCs) isolated from bone marrow, adipose tissue, and umbilical cord show considerable promise for use in cartilage repair. MSCs can be sourced from any or all joint tissues and can modulate the immune response. Additionally, MSCs can directly differentiate into chondrocytes under appropriate signal transduction. They also have immunosuppressive and anti-inflammatory paracrine effects. This article reviews the current clinical applications of MSCs and future directions of research in osteoarthritis.
Variable separation method based analytical model for surface potential profile of triple material double gate MOSFETs

The concept of integration of transistors evolves towards smaller line widths. This can be achieved by the prominent Very Large Scale Integration (VLSI) technology. The level of integration of silicon technology as measured in terms of number of devices per IC. This leads to the idea of scaling in MOSFET (Metal Oxide Semiconductor Field Effect Transistor) devices. Scaling enhances the design or manufacturing of extremely small complex circuitry using modified semiconductor material. But eventually scaling leads to short channel effects (SCEs). To enable future technology scaling, new device structures like MULTIGATE MOSFET refers to a MOSFET (metal-oxide-semiconductor field-effect transistor) which includes quite one gate into a sole device have been proposed. These Nano scale devices have a significant potential to scale beyond the perceived scaling limitations of traditional CMOS (Complementary Metal Oxide Semiconductor). The present work involves several distinct features, viz. The main objective is to reduce the Short Channel Effects (SCE) and effects of surface potential variation by using Triple Material Double Gate MOSFET (TMDG) in which the gate is made of three materials with different work functions. For analysing a short channel effects in Triple material double gate MOSFET, a 2-D Analytical channel potential and minimum surface potential is developed by solving the two dimensional Poisson's equation using variable separation method(superposition technique). To simulate surface potential behavior of TMDG, TCAD Simulator is used for investigating novel features offered by the device.
Technology Developed in GICE from the Director

In honor of Dr. Kao’s visit, GICE and College of EECS, GIPO, EE Dept., and NSC co-hosted a speech dedicated to the Father of Fiber Optic Communication to honor his achievements and dedication. Prof. Chinlon Lin, the former Professor and Director of Center for Advanced Research in Photonics of Chinese University of Hong Kong, introduced Dr. Kao’s research and career during the presentation. (upper left) Dean L. S. Lee (upper right) and GICE Director K. C. Chen (upper left) photographed with Dr. Kao and Mrs. Kao.
Effects of plastic hatching timing carry over through metamorphosis in red-eyed treefrogs

Environmentally cued plasticity in hatching timing is widespread in animals. As with later life-history switch points, plasticity in hatching timing may have carryover effects that affect subsequent interactions with predators and competitors. Moreover, the strength of such effects of hatching plasticity may be context dependent. We used red-eyed treefrogs, Agalychnis callidryas, to test for lasting effects of hatching timing (four or six days post-oviposition) under factorial combinations of resource levels (high or low) and predation risk (none, caged, or lethal Pantala flavescens dragonfly naiads). Tadpoles were raised in 400-L mesocosms in Gamboa, Panama, from hatching until all animals had metamorphosed or died, allowing assessment of effects across a nearly six-month period of metamorphosis. Hatching early reduced survival to metamorphosis, increased larval growth, and had context-dependent effects on metamorph phenotypes. Early during the period of metamorph emergence, early-hatched animals were la.
Individually Tailored Treatment of Medication Nonadherence

Objective: Nonadherence is a significant health care issue in pediatric inflammatory bowel disease (IBD) that requires intervention to improve outcomes. This pilot randomized controlled trial was designed to evaluate the feasibility, acceptability, and preliminary efficacy of an individually tailored behavioral treatment for nonadherence in adolescents with IBD. Patients and Methods: Fourteen adolescents ages 14.89 ± 2.01 years were randomly assigned to immediate care or wait list control conditions and received a manualized individually tailored behavioral intervention for nonadherence. Medication adherence, measured by pill count, served as the primary endpoint. Parents provided demographic data and ratings of intervention acceptability and patients provided disease-severity data. Results: Feasibility of the treatment was demonstrated by 100% treatment session attendance for all of the patients enrolled in the trial. Both parent and patient acceptability ratings were favorable. Comparison of baseline with posttreatment percent adherence across both conditions demonstrated that treatment resulted in a 4% gain in 6-mercaptopurine/azathioprine adherence (52% at baseline; 56% at posttreatment; &dgr; = 0.07) and a 25% gain in mesalamine adherence (43% at baseline; 68% at posttreatment; &dgr; = 0.57). Conclusions: Individually tailored treatment of nonadherence in adolescents with IBD is feasible and may result in substantial improvement in medication adherence. Differential effect of the intervention on medications requires further investigation, but it may reflect differences in regimen complexity, concerns about medication adverse effects, and/or patient/parent preference to target more complex regimens. Large-scale testing of this intervention is needed to demonstrate effect on clinical outcomes.
Learner Preferences in Multimedia Design

From the multimedia research, a number of design principles have been developed in order to improve learning by reducing burden on working memory load (i.e., the multimedia principles). However, very little of this research has attempted to examine learners’ preferences of multimedia design. As a result, the purpose of this study was to examine learners’ preferences for multimedia in order to see if design principles align with learner preferences. The results of the study indicate that learners’ preferences partially align with the multimedia principles. Learners preferred multiple to single representations, which is directly in-line with the multimedia principle. However, learners overwhelmingly preferred text + narration + images which directly violates the redundancy principle. They indicated that they prefer options. They enjoy seeing the images and then want to choose if they want to listen, read, or do both. Given these results, it is clear that the multimedia principles are not always aligned with learner preferences.
Flexibility assessment platform for the factory of the future

In order to assign an important role to flexibility, companies must first find a way to quantitatively measure flexibility. In this work, we attempt to address this problem and provide industrial users with a holistic platform capable of quantitatively assessing flexibility. The solution presented has two main objectives. Firstly, to provide engineers with appropriate measures in order to successfully gauge flexibility quantitatively. Secondly, to integrate the provided measures into a flexibility assessment platform by taking advantage of modern information technologies. This will result in the formation of a flexibility assessment platform, expected to become a useful asset to production engineers and stakeholders.
High Oxygen Affinity Hemoglobin Variant in a Canadian Family: Hb Bunbury [β94(FG1)Asp→Asn, GAC→AAC]

We investigated a three-generation Canadian family in which individuals displayed varying degrees of erythrocytosis due to a high oxygen affinity β chain hemoglobin (Hb) variant [Hb Bunbury, β94(FG1)Asp→Asn, GAC→AAC]. This is the fourth reported case of Hb Bunbury.
Review on Prediction of Churn Customer Behavior

has been major research problem with the growth of market development as customer’s asset more valuable persons for growth of company. The task of churn prediction is to identify the customers who are pretending to shift from one company to another. As in the competitive environment, it becomes necessary to focus on retaining churn customers as well as attracting new customers. The overall objective of this paper is to compare the various algorithms of Data Mining have been used for making distinguish between customers into loyal and churn, so that appropriate steps can be taken into consideration in order to retain the churn customers to the company as customers are more valuable to the survival and development of the company.
Plasma aldosterone concentrations and plasma renin activity in healthy dogs and dogs with hyperadrenocorticism

The mean (se) basal plasma aldosterone concentrations were significantly lower in 31 dogs with pituitary-dependent hyperadrenocorticism (PDH) (75 [9] pmol/litre) than in 12 healthy dogs (118 [14] pmol/litre), whereas in five dogs with hyperadrenocorticism due to an adrenocortical tumour they were significantly higher (205 [109] pmol/litre). The mean basal renin activity was not significantly different between the dogs with PDH (303 [48] fmol/litre/second), the dogs with an adrenocortical tumour (141 [63] fmol/litre/second), and the control dogs (201 [25] fmol/litre/second). At three and four hours after the intravenous administration of 0.1 mg/kg dexamethasone, the concentrations of aldosterone decreased significantly to about 60 per cent of their initial values in the control dogs but did not change in the dogs with PDH or an adrenocortical tumour. In the dogs with PDH the renin activity increased significantly after the administration of dexamethasone.
Genetic algorithm restricted by tabu lists in data mining

The present work shows an implementation of a genetic algorithm (GA) integrated with tabu lists to generate a classifier tool for a data mining task. The choice of the GA paradigm is partially justified by its great capacity to deal with noise, invalid or inexact data, and its easy adaptation to different data domains. The GA algorithm uses a tabu list to restrict the selection process. This restriction allows the creation of set of potential rules for the classifier tool. This strategy was proposed by Kurahashi et al. (2000), for multimodal and multiobjective function optimization and represents an alternative to sharing methods. In this work, the behavior of this approach in data mining task was analyzed. Experiments were performed on five databases and results were compared with 34 other classifying algorithms. After that, noise was added to the databases and a new set of experiments was performed. The results show that the algorithm proposed is efficient and robust. And the strategy used to maintain the diversity was considered valid, since the algorithm was able to keep its accuracy in categorization even for smaller populations.
Partial discharge: overview and signal generation

It is shown how a partial discharge (PD) within a test sample generates a signal that can be measured outside the apparatus under test. Because the transfer function between the phenomenon within the apparatus under test and the signal that can be measured can vary widely, measured partial-discharge magnitudes rarely have absolute meaning and are often referred to as effective partial-discharge magnitude to acknowledge this uncertainty. The most common sources of PD are floating components, corona, and voids. Each of these is considered in turn, and the fundamentals of how the phenomenon generates a current in the external circuit are explained. <<ETX>>
EFFECTS OF HYDRAULIC BACKWASH LOAD ON EFFLUENT QUALITY OF UPFLOW BAF

Using an upflow biological aerated filter (BAF) with treatment capacity of 100 ton/day, various hydraulic loads of backwashing water and influent were investigated to determine how they affect effluent quality of BAF during normal operation. The BAF packed with expanded polypropylene media of 3–5 mm diameter was operated over a five-month period for paper wastewater treatment. The average removal efficiencies of 78% for chemical oxygen demand (COD) and 88% for suspended solids (SS) were maintained, but the effluent CODs varied between 5–60 mg/l depending on the biodegradable fraction of influent wastewater. During normal BAF operation with cyclic backwash, the effluent SS concentrations showed initial peaks after backwash and gradually decreased to a steady state, while the soluble CODs of effluent did not significantly changed. The effluent SS concentrations and the required time intervals to reach steady state after backwash were related with hydraulic loads of backwashing water and influent wastewater applied to the BAF. A higher load of backwashing water gave larger deviation of initial SS peaks from the steady state, the extent of which was more significant under the higher load of influent wastewater.
Measurement of prostate-specific antigen in serum as a screening test for prostate cancer.

BACKGROUND Prostate-specific antigen (PSA) is secreted exclusively by prostatic epithelial cells, and its serum concentration is increased in men with prostatic disease, including cancer. We evaluated its usefulness in the detection and staging of prostate cancer. METHODS We measured serum PSA concentrations in 1653 healthy men 50 or more years old. Those with PSA values greater than or equal to 4.0 micrograms per liter then underwent rectal examination and prostatic ultrasonography. Ultrasound-directed prostatic needle biopsies were performed in the men with abnormal findings on rectal examination, ultrasonography, or both. The results were compared with those in 300 consecutively studied men 50 or more years old who underwent ultrasound-directed biopsy because of symptoms or abnormal findings on rectal examination. RESULTS Serum PSA levels ranged from 4.0 to 9.9 micrograms per liter in 6.5 percent of the 1653 men (107). Nineteen of the 85 men in this group (22 percent) who had prostatic biopsies had prostate cancer. Serum PSA levels were 10.0 micrograms per liter or higher in 1.8 percent of the 1653 men (30). Eighteen of the 27 men in this group (67 percent) who had prostatic biopsies had cancer. If rectal examination alone had been used to screen the men who had biopsies, 12 of the 37 cancers (32 percent) would have been missed. If ultrasonography alone had been used to screen these men, 16 of the 37 cancers (43 percent) would have been missed. Serum PSA measurement had the lowest error rate of the tests, and PSA measurement plus rectal examination had the lowest error rate of the two-test combinations. CONCLUSIONS The combination of measurement of the serum PSA concentration and rectal examination, with ultrasonography performed in patients with abnormal findings, provides a better method of detecting prostate cancer than rectal examination alone.
Analyse des images de tomographie par émission de positons pour la prédiction de récidive du cancer du col de l'utérus

Ces travaux de these s'inscrivent dans le contexte de la prediction de la recidive en radiotherapie du cancer de l'uterus. L'objectif etait d'analyser les images de tomographie par emission de positons (TEP) au 18F-fluorodesoxyglucose (18F-FDG) en vue d'en extraire des parametres quantitatifs statistiquement correles aux evenements de recidive. Six etudes ont ete realisees afin de repondre aux differentes problematiques soulevees par l'analyse des images 18F-FDG TEP telles que la presence d'artefact, l'isolation du metabolisme tumoral ou l'evaluation du signal en cours de traitement. Les etudes statistiques ont porte sur l'analyse de parametres refletant l'intensite, la forme et la texture du metabolisme tumoral avant, et en cours de traitement. A l'issue de ces travaux, le volume metabolique tumoral pre-therapeutique ainsi que la glycolyse totale de la lesion per-therapeutique apparaissent comme les parametres les plus prometteurs pour la prediction de recidive de cancers du col de l'uterus. De plus, il apparait que la combinaison de ces parametres avec d'autres caracteristiques de texture ou de forme, a l'aide de modeles statistiques d'apprentissage supervise ou de modeles de regression plus classiques, ont permis d'augmenter la prediction des evenements de recidive.
Characteristics of Gate-All-Around Twin Poly-Si Nanowire Thin-Film Transistors

We have investigated the characteristics of gate-all-around (GAA) twin polycrystalline-silicon nanowire (NW) thin-film transistors (TFTs). The NW channel and surrounding gate imparted the GAA twin NW TFT with superior channel controllability. Moreover, the combination of the high surface-to-volume ratio of the NW and the split channel structure led to highly efficient NH3 plasma treatment, which reduced the effective grain-boundary trap-state density. The GAA twin NW TFT exhibited greatly improved electrical performance, including a lower threshold voltage, a steeper subthreshold swing (114 mV/dec), a higher on/off current ratio (> 108), and a virtual absence of drain-induced barrier lowering (13 mV/V).
Electron microscopic immunostaining of nerve growth factor: Secretagogue stimulated submandibular glands

Immunocytochemical localization of nerve growth factor (NGF) was assessed on thin sections of plastic‐embedded male mouse submandibular glands by electron microscopy. Both control and secretagogue‐stimulated glands were examined. NGF was localized in granules of both granular convoluted tubule (GCT) cells and transition cells. The latter were intermediate in morphology between GCT cells and striated duct cells. Both large and small granules were immunostained in GCT cells; however, considerable variability in immunostaining intensity was observed in both sizes of granules but especially in the small granules of transition cells. Rough endoplasmic reticulum (RER) in both cell types exhibited NGF immunoreactivity. No Golgi‐associated immunostaining was observed.
Mixed Martial Art og det totale engagement

Mixed Martial Arts is a relatively new staging of the ultimate battle between two practitioners fighting in a cage. With it’s brutality it challenges the practitioner’s physical limits and mental barriers. In this article we go behind – or maybe rather before – the fight and describe the training practices of American MMA practitioners. Accordingly, the aim of this article is to describe the community of practices which MMA practitioners are part of – ‘backstage’ – when preparing for their fight(s).
QTor : une organisation basée sur les requêtes pour les systèmes distribués de gestion de ﬂux

La constante augmentation du nombre de donnees et flux de donnees disponibles sur Internet ainsi que le nombre toujours plus important d'utilisateurs les requetant necessitent d'ameliorer l'acces a des sources de donnees multiples et distribuees. La performance, le passage a l'echelle et l'adaptabilite d'un systeme d'interrogation de sources de donnees se trouvent au centre de problematiques visant a eviter tout goulot d'etranglement au niveau des sources de donnees et a permettre l'usage de langages de requete expressives. Ce papier presente l'approche nouvelle que nous proposons dans QTor (« Querry Torrent »), le projet sur lequel je travaille dans le cadre de ma these. Cette approche repose sur l'usage des relations mathematiques entre les requetes exprimees pour regrouper les utilisateurs en communautes d'interet, et organiser ces communautes entre elles afin d'obtenir, par un minimum d'operations, une reduction efficace des traitements redondants dans le systeme.
Public Key Pinning Extension for HTTP

This document defines a new HTTP header that allows web host operators to instruct user agents to remember ("pin") the hosts' cryptographic identities over a period of time. During that time, user agents (UAs) will require that the host presents a certificate chain including at least one Subject Public Key Info structure whose fingerprint matches one of the pinned fingerprints for that host. By effectively reducing the number of trusted authorities who can authenticate the domain during the lifetime of the pin, pinning may reduce the incidence of man-in-the-middle attacks due to compromised Certification Authorities.
Re: Pomerance et al. High‐level expression, activation, and subcellular localization of p38‐MAP kinase in thyroid neoplasms. J Pathol 2006; 209: 298–306

The neoplastic transformation of follicular thyroid cells essentially transmits signals to the mitogen-activated protein kinase (MAPK) pathways [1–3], which result in the activation of signal transduction cascades (JNK1, ERKs, and p38 kinases) [4,5]. The cascade end points include the MAPK-activated protein kinases and some of the numerous transcrip-tion factors that regulate apoptosis, inﬂammation, cell growth, and differentiation. The role of p38-MAPK has been recently emphasized in cell line studies from follicular thyroid neoplasms [3,6].
One-pot route to graft long-chain polymer onto silica nanoparticles and its application for high-performance poly(l-lactide) nanocomposites

A facile “one-pot” synthetic route to modify SiO2 nanoparticles with long-chain polymer was developed. The structure and morphology of SiO2 grafted with poly(l-lactide) (SiO2-g-PLA) were characterized by FTIR, TGA, GPC, and TEM. Furthermore, a series of PLA/SiO2-g-PLA nanocomposites were prepared with different nanofiller loadings, and their related performances were investigated. As an effective nucleating agent, the SiO2-g-PLA had a positive effect to improve the crystallization rate and increase the crystallinity. Meanwhile, the PLA nanocomposites presented outstanding mechanical properties including excellent toughness and high stiffness. In addition, the PLA materials kept good transparency with less than 3 wt% nanofillers. Overall, this work provides a useful method for preparing high-performance polymer nanocomposites.
Studies on the physicochemical properties of fenugreek (Trigonella Foenum-Graecum L.) seeds

Fenugreek (Trigonella foenum-graecum L.) is one of the most promising medicinal herbs known from ancient times having nutritional value. This study aimed at determining the physicochemical properties of fenugreek seeds in order to ascertain its quality as a food and medicinal agent. The proximate analysis was carried out based on standard methods of Association of Official Analytical Chemists (AOAC), while the vitamin composition was analyzed based on the method described in CODEX. Vitamin C was determined by titration method. The moisture and ash contents of the sample had average values of 10.91±0.85% and 2.99±0.48% respectively. The protein content had an average value of 2.74±0.35%, while fat and carbohydrate contents were 6.33±0.52% and 77.04±0.63% respectively. The vitamin B1, B2, B6 and B12 gave average values of 0.1137mg/g, 0.0366 mg/g, 0.0495 mg/g and 0.8710 mg/g respectively, whereas vitamin C and folic acid contents had values of 10.5400 mg/g and 0.0386 mg/g respectively. The aqueous extract of fenugreek seeds found vitamins, carbohydrates, proteins and fats may be a very good source of food supplement and has potential for treating diverse medical ailments which supports its traditional use.