Miracle-dz/UniFAR-FTUs huggingface dataset:
ElementaryMode Analysis for the Rational Design of Efficient Succinate Conversion fromGlycerol by Escherichia coli

By integrating the restriction of oxygen and redox sensing/regulatory system, elementary mode analysis was used to predict the metabolic potential of glycerol for succinate production by E. coli under either anaerobic or aerobic conditions. It was found that although the theoretical maximum succinate yields under both anaerobic and aerobic conditions are 1.0 mol/mol glycerol, the aerobic condition was considered to be more favorable for succinate production. Although increase of the oxygen concentration would reduce the succinate yield, the calculation suggests that controlling the molar fraction of oxygen to be under 0.65 mol/mol would be beneficial for increasing the succinate productivity. Based on the elementary mode analysis, the rational genetic modification strategies for efficient succinate production under aerobic and anaerobic conditions were obtained, respectively. Overexpressing the phosphoenolpyruvate carboxylase or heterogonous pyruvate carboxylase is considered to be the most efficient strategy to increase the succinate yield.
Marine-Derived Secondary Metabolites as Promising Epigenetic Bio-Compounds for Anticancer Therapy

Sessile organisms such as seaweeds, corals, and sponges continuously adapt to both abiotic and biotic components of the ecosystem. This extremely complex and dynamic process often results in different forms of competition to ensure the maintenance of an ecological niche suitable for survival. A high percentage of marine species have evolved to synthesize biologically active molecules, termed secondary metabolites, as a defense mechanism against the external environment. These natural products and their derivatives may play modulatory roles in the epigenome and in disease-associated epigenetic machinery. Epigenetic modifications also represent a form of adaptation to the environment and confer a competitive advantage to marine species by mediating the production of complex chemical molecules with potential clinical implications. Bioactive compounds are able to interfere with epigenetic targets by regulating key transcriptional factors involved in the hallmarks of cancer through orchestrated molecular mechanisms, which also establish signaling interactions of the tumor microenvironment crucial to cancer phenotypes. In this review, we discuss the current understanding of secondary metabolites derived from marine organisms and their synthetic derivatives as epigenetic modulators, highlighting advantages and limitations, as well as potential strategies to improve cancer treatment.
Investigation of Children's Plantar Pressure Distribution with Varied Angle of Hallux

INVESTIGATION OF CHILDREN'S PLANTAR PRESSURE DISTRIBUTION WITH VARIED ANGLE OF HALLUX ABSTRACT. Fashion shoes with narrow and tight toe are widely designed for children and their influence was rarely considered. Therefore, the aim of this study is to investigate children's plantar pressure distribution with varied angle of hallux (AoH), so as to simulate the effect of the tight shoes on the children's feet. Totally, 892 healthy children aged between two and 11 were recruited and those with the foot deformities were excluded by an experienced clinical expert. Both the dynamic AoH and plantar pressure distribution were measured by a pressure plate, with the two-steps protocol and self-selected walking speed. Regions of Hallux, medial
FSR based Force Myography ( FMG ) Stability Throughout Non-Stationary Upper Extremity Tasks

Force Myography (FMG) is a method of tracking movement and functional activity that is based on the volumetric changes that occur in a limb during muscle contraction. There are several advantages of FMG over other myographic modalities that support its implementation in rehabilitative and assistive technology to track upper extremity movement during activities of daily living. The aim of the current work is to explore the stability of FMG sensors during non-static upper extremity activities. Twenty-one participants with varying age and gender were recruited to perform a set of tasks while wearing a custom FMG band. The participants were required to move between two extremes of range of motion (wrist flexion/extension and forearm pronation/supination) or between two extremes of grasp force (squeeze and relax). FMG presented low variability (<6%) and demonstrated little to no drift with ongoing task duration (Spearman’s |R| < 0.3). FMG variability did not present any relationship to differences in anthropometry or grip strength (Spearman’s |R| < 0.3), suggesting that FMG wearers will present a stable FMG signal despite differing musculoskeletal characteristics. Finally, variability in FMG presented no significant relationship between user variables and the testing accuracies of machine learning models trained on FMG data. The results of this study demonstrate the stability of FMG signals during non-stationary tasks and support the potential of implementing FMG into user-machine interface technology. Keywords—Activities of daily living; age-related rehabilitation; assistive technology; biomedical devices; human factors; independent living; prosthetic control; sensors/sensor application; force myography
POWER DELAY PROFILE ESTIMATION TECHNIQUE FOR LMMSE CHANNEL ESTIMATOR OF MIMO-OFDM SYSTEM

A multiple-input multiple-output (MIMO) communication system combined with the orthogonal frequency division multiplexing (OFDM) modulation technique can achieve reliable high data rate transmission over broadband wireless channels. But the performance gain depends heavily on accurate channel estimation. In linear-minimum-mean-Square error (LMMSE) channel estimation for multicarrier system, one needs to know the channel statistics. We propose a power delay profile (PDP) estimation technique to obtain the frequency domain channel statistics at the receiver. The pilot symbols of all transmit antenna ports are used in estimating the PDP. The estimated PDP is used to generate the LMMSE filter Coefficients for data-subcarrier channel estimation. The distortions caused by null subcarriers and an insufficient number of samples for PDP estimation are also considered. The proposed technique effectively reduces the distortions for accurate PDP estimation. Simulation results show that the performance of LMMSE channel estimation using the proposed PDP estimate approaches that of Wiener filtering due to the mitigation of distortion effects.
Chaotic quadruple secular evolution and the production of misaligned exomoons and Warm Jupiters in stellar multiples

We study the chaotic and secular evolution of hierarchical quadruple systems in the $3+1$ configuration, focusing on the evolution of mutual inclination of the inner binaries as the system undergoes coupled Lidov-Kozai (LK) oscillations. We include short-range forces (SRF; such as those due to tidal and rotational distortions) that control the eccentricity excitation of the inner binary. The evolution of mutual inclination is described, a priori, by two dimensionless parameters, $\pazocal{R}_0$, the ratio between the inner and outer LK time-scales and $\epsilon_{SRF}$, the ratio between the SRF precession and the inner LK precession rates. We find that the chaotic zones for the mutual inclination depend mainly on $\pazocal{R}_0$, while $\epsilon_{SRF}$ controls mainly the range of eccentricity excitation. The mutual inclination evolves chaotically for $1\lesssim \pazocal{R}_0\lesssim 10$, leading to large misalignments. For $0.4 \lesssim \pazocal{R}_0 \lesssim 0.8$, the system could be weakly excited and produce bimodal distribution of mutual inclination angles. Our results can be applied to exomoons-planets in stellar binaries and Warm/Hot Jupiters in stellar triples. Such systems could develop large mutual inclination angles if the inner binary is tight enough, and also high eccentricities, depending of the strength of the short-range forces. Future detections of tilted Warm/Hot Jupiters and exomoons could put our mechanism under observational tests.
Interaction and eruption of two filaments observed by Hinode, SOHO, and STEREO

We investigate the interaction between two filaments and the subsequent filament eruption event observed from different viewing angles by Hinode, the Solar and Heliospheric Observatory, and the Solar Terrestrial Relations Observatory. In the event, the two filaments rose high, interacted with each other, and finally were ejected along two different paths. We measure the bulk-flow velocity using spectroscopic data. We find significant outflows at the speed of a few hundreds of km s−1 during the filament eruption, and also some downflows at a few tens of km s−1 at the edge of the eruption region in the late stage of the eruption. The erupting material was composed of plasmas with a wide temperature range of 104–106 K. These results shed light on the filament nature and the coronal dynamics.
LOW-Γ JETS FROM COMPACT STELLAR MERGERS: CANDIDATE ELECTROMAGNETIC COUNTERPARTS TO GRAVITATIONAL WAVE SOURCES

Short gamma-ray bursts (GRBs) are believed to be produced by relativistic jets from mergers of neutron stars (NSs) or NSs and black-holes (BHs). If the Lorentz-factors Γ of jets from compact stellar mergers follow a similar power-law distribution to those observed for other high-energy astrophysical phenomena (e.g., blazars, active galactic nuclei), the population of jets should be dominated by low-Γ outflows. These jets will not produce prompt gamma-rays, but jet energy will be released as X-ray/optical/radio transients when they collide with the ambient medium. Using Monte Carlo simulations, we study the properties of such transients. Approximately 78% of merger jets Mpc result in failed GRBs if the jet Γ follows a power-law distribution of index −1.75. X-ray/optical transients from failed GRBs will have broad distributions of their characteristics: light-curves peak days after a merger; flux peaks for X-ray mJy; and optical flux peaks at . X-ray transients are detectable by Swift XRT, and of optical transients will be detectable by telescopes with limiting magnitude , for well localized sources on the sky. X-ray/optical transients are followed by radio transients with peak times narrowly clustered around days, and peak flux of ∼10–100 mJy at 10 GHz and ∼0.1 mJy at 150 MHz. By considering the all-sky rate of short GRBs within the LIGO/Virgo range, the rate of on-axis orphan afterglows from failed GRBs should be 2.6(26) per year for NS–NS(NS–BH) mergers, respectively. Since merger jets from gravitational-wave (GW) trigger events tend to be directed to us, a significant fraction of GW events could be associated with the on-axis orphan afterglow.
Health-related quality of life of patients colonized or infected with multidrug-resistant organisms

Aim: Due to their resistance against multiple antibiotics, multidrugresistant bacteria (MDRO) impose higher costs upon health care proFranziska Claus Walter Ried viders and involve several risks for the health of patients. In the first place, the present paper aims to report on the applicability of amodified version of the German Short Form-36 (SF-36) Health Survey to address 1 University of Greifswald, Chair of Public Finance, Greifswald, Germany health-related quality of life (HRQoL) of inpatients colonized or infected withMDRO. Additionally, the study analyzes effects on HRQoL of affected patients. Methods: A prospective intervention study was conducted to implement a multimodal hygiene program against MDRO in acute care hospitals within the Health Region Baltic Sea Coast in Germany. HRQoL was assessed at discharge from the attending ward and six months after, respectively. In addition, the SF-6D as a preference-based measure of health was calculated. In order to control for confounders, statistical matching was performed using the variables age, gender, hospital, hospital status (i.e., intervention vs. control group of the empirical study) and attending ward as matching criteria. Results: Inpatients with MDRO (n=27) on average report lower scores for themajority of subscales. In addition, for these patients the component summary scores and the SF-6D are lower as well. With respect to follow-up examinations, the empirical data lead to no clear-cut impact on HRQoL for patients tested positive during their hospital stay. Conclusion: Themodified version of the German SF-36 has been shown to be a suitable instrument to measure HRQoL of patients colonized or infected withMDRO. In particular, our results indicate thatMDRO impose a risk upon the health of colonized patients. As a consequence, effective prevention measures against MDRO may not only be beneficial for health care providers but for affected patients and for society as well.
Analysis on the circulation characteristics of summer precipitation conversion in North China.

In this paper, a comprehensive analysis on decadal shift of precipitation rainfall pattern and circulation characteristics during summer in North China is made based on such data as daily precipitation, general atmospheric circulation reanalyzed by NCEP/NCAR. The results of the analysis indicate that: 1) The shift of precipitation rainfall pattern during summer in Eastern China can be divided into 5 periods, i.e., 1961-1965 with significantly more rainfall both in North China and Northeast China, 1966-1980 with more rainfall in North China but normally less rainfall in Northeast China, 1981-2000 with more rainfall in Northeast China but normally less rainfall in North China, 2001-2010 with less rainfall in North China and Northeast China but significantly more rainfall in Huaihe River Basin, and 2011-2013 with more rainfall in North China and Northeast China but less rainfall in Yangtze-Huaihe River Basin. 2) In recent years, the precipitation in rainy season (summer) in North China and Northeast China is similar to that during 1961-1965, which is significantly high. However, the circulation pattern is significantly different from that during 1961-1965. For the sea-level pressure field in summer, the low-pressure center in Mongolia was located in South Central Mongolia during 1961-1965, with low pressure trough significantly deepened; while it was located in Eastern Mongolia and toward North China and Northeast China during 2011-2013, with low pressure trough significantly weakened. At 500 hPa height field, Siberia trough and North China trough were deepened but Baikal Lake Ridge was weakened during 1961-1965. Besides, the “step trough” brought more rainfall to North China and Northeast China. During 2011-2013, however, the Baikal Lake Ridge was normal, the geopotential height of Okhotsk Sea was increased, the subtropical high was located northward, and the blocking effect by the eastern part on the North China trough was strengthened, resulting in more rainfall during summer in North China and Northeast China. At 850 hPa wind field, southerly wind was obviously
Introduction – coopetition strategies : towards a new form of inter-organizational dynamics ?

economics to an understanding of reallife interfi rm relationships. This state of aff airs leads to the emergence of a clear necessity to enhance management research in this direction. 3. COOPETITION STRATEGIES – THE RESEARCH OBJECT The fi rst challenge of a new theoretical approach is usually to defi ne the boundaries of the concept under investigation. Since the seminal work by Nalebuff and Brandenburger (1996), coopetition has been the focus of a growing body of researchers. It had in eff ect started in Europe, developing from a number of key events. In 2002, there were 13 paper presentations at a European Academy of Management (EURAM) conference track dedicated to coopetition strategy. In 2004, a European Institute for Advanced Studies in Management (EIASM) workshop was held in Catania (34 of the 53 submitted papers were accepted). EIASM presented a second workshop in the series in Milan’s SDA Bocconi in 2006 (34 of the 44 presented papers were accepted). In 2007 there was a coopetition track at the EURAM conference (12 of the 24 submitted papers were accepted), followed by a third EIASM workshop in Madrid in 2008. In 2009 a Professional Development Workshop on ‘Coopetition strategy: current issues and future research directions’ was held at the Academy of Management annual conference in Chicago. An invited workshop on ‘Coopetition and Entrepreneurship’ has been organized in June 2010 in Montpellier. Finally, in 2010, an EIASM coopetition workshop is scheduled to be held in Montpellier on June 17 and 18, under the broadspectrum label ‘Coopetition and Innovation’ and a track named ‘Coopetition strategy’ will be organized at the IFSAM Conference in Paris. Special issues of publications also refl ect the growing body of literature in the coopetition fi eld. For instance, in International Studies of Management and Organization (Vol.37, no.2, 2007), and Management Research (Vol.6, no.3), while the International Journal of Entrepreneurship and Small Business links coopetition to entrepreneurship (Vol.8, no. 2009). Some books are under way; the fi rst one is for Routledge on Coopetition Strategy: Theory Experiments and Cases (Dagnino and Rocco, 2009). This Edward Elgar book is a collection of some of the best contributions extracted from the Paris EURAM track in 2007 and the Milan EIASM workshop on coopetition in 2006. The emerging coopetition community is founded on the idea that coopetition requires a dedicated theoretical approach. It is noteworthy that diff erent authors, however, capture the concept diff erently. In its broadest Saïd Yami, Sandro Castaldo, Giovanni Battista Dagnino, Wojciech Czakon and Frederic Le Roy 9781849807241 Downloaded from Elgar Online at 02/27/2019 11:16:51PM
Three‐year outcomes of peripheral blood mononuclear cells vs purified CD34 + cells in the treatment of angiitis‐induced no‐option critical limb ischemia and a cost‐effectiveness assessment: A randomized single‐blinded noninferiority trial

For patients with angiitis‐induced critical limb ischemia (AICLI), cell transplantation, such as purified CD34+ cells (PCCs) and peripheral blood mononuclear cells (PBMNCs), is gradually being used as a promising treatment. This was the first randomized single‐blinded noninferiority trial (number: NCT 02089828) specifically designed to evaluate the therapeutic efficacies of the transplantation of PCCs vs those of PBMNCs for the treatment of AICLI. We aimed to compare the mid‐term safety and efficacy between the two groups and determine their respective advantages. From April 2014 to September 2019, 50 patients with AICLI were equally allocated to the two groups, except for 1 lost patient, 1 amputee, and 1 patient who died of heart disease. The other 47 patients completed the 36‐month follow‐up. The endpoints were as follows: major amputation‐free survival and total amputation‐free survival at 6 months, which were 96.0% and 84.0% in the PBMNCs group and 96.0% and 72.0% in the PCCs group, respectively. These rates remained stable at 12, 24, and 36 months. The PCCs group had a significant higher probability of rest pain relief than the PBMNCs group, whereas earlier significant improvements in the Rutherford classification were observed in the PBMNCs group. Accordingly, PCCs would be preferred for patients with significant pain, whereas PBMNCs may be a good option for patients with two or more critically ischemic limbs. Concerning cost‐effectiveness, PCCs are not more cost‐effective than PBMNCs. These outcomes require verification from long‐term trials involving larger numbers of patients.
Heat-Not-Burn , Modified Risk Tobacco Product , Actual Use , Product Adoption

This was a pre-market actual use study with the Tobacco Background: Heating System (THS), a candidate modified risk tobacco product, conducted with adult smokers in eight cities in the United States. The main goal of the study was to describe THS adoption in a real-world setting. The aim of this analysis was to identify potential predictors for adoption of THS using stepwise logistic regression method. This actual use study was an observational study assessing Methods: self-reported stick-by-stick consumption of the THS product compared with the use of commercial cigarettes over six weeks. The study aimed at replicating the usage of THS in real-world conditions with participants being able to consume cigarettes, THS, and any other nicotine-containing products (e.g., e-cigarettes, cigars, etc.) . ad libitum 14.6% of participants adopted THS, which comprised 70% or Results: more of their total tobacco consumption by the end of the observational period (in Week 6). The main predictors of adoption were the liking of the smell, taste, aftertaste, and ease of use of THS. The proportion of adoption was higher in participants aged 44 years and older and in Hispanic or Latino adult smokers. Additionally, adoption of THS was more likely in participants who had never attempted to quit smoking and in participants who smoked up to 10 cigarettes per day. Finally, the adoption of THS was higher in participants who consumed both regular and menthol THS compared with those who consumed only one THS variant. The main predictors of THS adoption were positive sensory Conclusions: assessment and the ease of use. Socio-demographic characteristics and smoking habits appeared much less important. Post-marketing studies will provide further insights on the impact of the THS at the individual and the overall population level. 1 2 3 4
A bearing fault detection method with low-dimensional compressed measurements of vibration signal

The traditional bearing fault detection method is achieved often by sampling the bearing vibration data under the Shannon sampling theorem. Then the information of the bearing state can be extracted from the vibration data, which is used in fault detection. A long-term and continuous monitoring needs to sample and store large amounts of raw vibration signals, which will burden the data storage and transmission greatly. For this problem, a new bearing fault detection method based on compressed sensing is presented, which just needs to sample and store a small amount of compressed observation data and uses these data directly to achieve the fault detection. Firstly, an over-complete dictionary is trained, on which the vibration signals corresponded to normal state can be decomposed sparsely. Then, the bearing fault detection can be achieved based on the difference of the sparse representation errors between the compressed signals in normal state and fault state on this dictionary. The fault detection results of the proposed method with different parameters are analyzed. The effectiveness of the method is validated by the experimental tests.