Miracle-dz/UniFAR-FTUs huggingface dataset:
Interaction design for Web-based, within-page collection making and management

A common issue in Web browsing is how to manage information found while browsing or searching. The usual approach is either to bookmark an entire page when perhaps only one element is relevant, or to copy information from the page and paste it into a second application, such as a text editor. Neither approach is sufficient. Bookmarks over capture data; copying and pasting components implies that users must shift task focus from search tasks to information management tasks. This forced divided attention [8] between knowledge discovery and information management generally compromises both tasks. In this paper, we look at our iterative process to determine requirements for a tool to support the gathering process. In particular, we consider how these requirements have raised other issues about this interactive process, and how, by further evaluation, we hope to develop a richer Web-based design heuristics for within-page collections.
Roles of Arrest-Defective Protein 1225 and Hypoxia-Inducible Factor 1α in Tumor Growth and Metastasis

Background Vascular endothelial growth factor A (VEGFA), a critical mediator of tumor angiogenesis, is a well-characterized target of hypoxia-inducible factor 1 (HIF-1). Murine arrest-defective protein 1A (mARD1A225) acetylates HIF-1α, triggering its degradation, and thus may play a role in decreased expression of VEGFA. Methods We generated ApcMin/+/mARD1A225 transgenic mice and quantified growth of intestinal polyps. Human gastric MKN74 and murine melanoma B16F10 cells overexpressing mARD1A225 were injected into mice, and tumor growth and metastasis were measured. VEGFA expression and microvessel density in tumors were assessed using immunohistochemistry. To evaluate the role of mARD1A225 acetylation of Lys532 in HIF-1α, we injected B16F10-mARD1A225 cell lines stably expressing mutant HIF-1α/K532R into mice and measured metastasis. All statistical tests were two-sided, and P values less than . 05 were considered statistically significant. Results ApcMin/+/mARD1A225 transgenic mice (n = 25) had statistically significantly fewer intestinal polyps than ApcMin/+ mice (n = 21) (number of intestinal polyps per mouse: ApcMin/+ mice vs ApcMin/+/mARD1A225 transgenic mice, mean = 83.4 vs 38.0 polyps, difference = 45.4 polyps, 95% confidence interval [CI] = 41.8 to 48.6; P < .001). The growth and metastases of transplanted tumors were also statistically significantly reduced in mice injected with mARD1A225-overexpressing cells than in mice injected with control cells (P < .01). Moreover, overexpression of mARD1A225 decreased VEGFA expression and microvessel density in tumor xenografts (P < .04) and ApcMin/+ intestinal polyps (P = .001). Mutation of lysine 532 of HIF-1α in B16F10-mARD1A225 cells prevented HIF-1α degradation and inhibited the antimetastatic effect of mARD1A225 (P < .001). Conclusion mARD1A225 may be a novel upstream target that blocks VEGFA expression and tumor-related angiogenesis.
Effect of gender on psychosocial adjustment of colorectal cancer survivors with ostomy.

BACKGROUND Stoma can pose extensive challenges for colorectal cancer survivors. Identifying the psychological and social adjustment among them and how it differs by gender will aid in identifying those particularly at risk of having poor adjustment and in planning programs to improve their adjustment. The purpose of this study was to determine the effect of gender on psychosocial adjustment of colorectal cancer survivors with ostomy. METHODS A descriptive cross sectional study was carried out in the stoma clinic of B.P. Koirala Memorial Cancer Hospital, Bharatpur, Nepal. A purposive sample of 122 patients with ostomy was taken from the above mentioned setting. Selection criteria included colorectal cancer survivors having ostomy for at least 6 months. Data on socio-demographic and clinical variables were collected. Psychosocial adjustment was measured using Ostomy Adjustment Inventory-23 (OAI-23). RESULTS A total of 122 patients were included in the study. Mean time since ostomy surgery was 2.53 and 1.98 years for men and women respectively. Both men and women had significant impairment in the psychosocial adjustment, however, men had significantly lower psychosocial adjustment score (37.68±12.96 vs. 43.45±12.81, t=-2.47, P=0.015) at 95% CI as compared to women and they reported more negative emotions. Furthermore, men significantly predicted low acceptance {β=-3.078, P=0.023, ΔR2=0.036, F [4,117] =7.90, P<0.001} and social engagement score {β=-2.501, P<0.001, ΔR2=0.098, F [4,117] =6.03, P<0.001}. CONCLUSIONS Colorectal cancer survivors with ostomy should be monitored for psychosocial concerns in regular basis and health care providers should tailor care based on their need. Approaches of survivorship care and psychosocial interventions in colorectal cancer survivors with ostomy should take into account gender specific concerns and requirements to aid adjustment.
Temporal Dynamics and Motivations for Urban Community Food Gardens in Medium-Sized Towns of the Eastern Cape, South Africa

Urban agriculture is said to be increasing with global urbanization. However, there is little examination of the temporal or spatial dynamics of urban agriculture. We investigated the benefits and challenges experienced by community gardeners in four towns in South Africa, along with GIS analysis of the number, area, and location of urban food community gardens over the last three decades. Common reasons for practicing community gardening were cash poverty (37%) and the need to grow food (34%). The most common benefits reported by respondents were a healthy lifestyle (58%) and consumption of the food produced (54%). Theft of garden infrastructure or produce was a noteworthy challenge to continued motivation and engagement in urban community gardening. There were declines in the number and area of urban community gardens, and more central location over the last three decades. Only 16% of the gardens present in the 1980s were still operating in the 2000s. Clearly community gardening is temporally and spatially dynamic, which requires context-sensitive policy initiatives.
NMDA Receptor‐dependent LTD in different subfields of hippocampus in vivo and in vitro

In simulations with artificial neural networks, efficient information processing and storage has been shown to require that the strength of connections between network elements has the capacity to both increase and decrease in a use‐dependent manner. In contrast to long‐term potentiation (LTP) of excitatory synaptic transmission, activity‐dependent long‐term depression (LTD) has been difficult to demonstrate in forebrain in vivo. Theoretical arguments indicate that coincidence of presynaptic excitation and low‐magnitude postsynaptic activation are the necessary prerequisites for LTD induction. Here we report that stimulation paradigms which cause 1) sufficient excitation to result in NMDA receptor activation and simultaneously 2) attenuate the level of postsynaptic activation by recruitment of GABAA receptor‐mediated inhibition consistently produce LTD of commissural input to area CA1 in the hippocampus of anesthetized adult rats, and of the perforant path input to the dentate gyrus in the hippocampus of anesthetized and unanesthetized adult rabbits. A functionally similar pre‐ and postsynaptic activation pattern applied to the hippocampal slice preparation by injecting hyperpolarizing current into the postsynaptic cell during NMDA receptor‐mediated excitation also was effective in consistently inducing LTD. Results of studies in vitro show that Ca2+ influx through the NMDA channel is necessary for the induction of LTD, and moreover, that NMDA receptors also participate in the expression of LTD. Our findings demonstrate a general mechanism for the implementation of a theoretically derived learning rule in adult forebrain in vivo and in vitro and provide justification for the inclusion of use‐dependent decreases of connection weights in formal models of cognitive processing. © 1996 Wiley‐Liss, Inc.
Computerized tomography-guided sphenopalatine ganglion pulsed radiofrequency treatment in 16 patients with refractory cluster headaches: Twelve- to 30-month follow-up evaluations

Background Sphenopalatine ganglion percutaneous radiofrequency thermocoagulation treatment can improve the symptoms of cluster headaches to some extent. However, as an ablation treatment, radiofrequency thermocoagulation treatment also has side effects. Objective To preliminarily evaluate the efficacy and safety of a non-ablative computerized tomography-guided pulsed radiofrequency treatment of sphenopalatine ganglion in patients with refractory cluster headaches. Methods We included and analysed 16 consecutive cluster headache patients who failed to respond to conservative therapy from the Pain Management Center at the Beijing Tiantan Hospital between April 2012 and September 2013 treated with pulsed radiofrequency treatment of sphenopalatine ganglion. Results Eleven of 13 episodic cluster headaches patients and one of three chronic cluster headaches patient were completely relieved of the headache within an average of 6.3 ± 6.0 days following the treatment. Two episodic cluster headache patients and two chronic cluster headache patients showed no pain relief following the treatment. The mean follow-up time was 17.0 ± 5.5 months. All patients enrolled in this study showed no treatment-related side effects or complications. Conclusion Our data show that patients with refractory episodic cluster headaches were quickly, effectively and safely relieved from the cluster period after computerized tomography-guided pulsed radiofrequency treatment of sphenopalatine ganglion, suggesting that it may be a therapeutic option if conservative treatments fail.
Functional Implementation of the Posttranslational SecB-SecA Protein-Targeting Pathway in Bacillus subtilis

ABSTRACT Bacillus subtilis and its close relatives are widely used in industry for the Sec-dependent secretory production of proteins. Like other Gram-positive bacteria, B. subtilis does not possess SecB, a dedicated targeting chaperone that posttranslationally delivers exported proteins to the SecA component of the translocase. In the present study, we have implemented a functional SecB-dependent protein-targeting pathway into B. subtilis by coexpressing SecB from Escherichia coli together with a SecA hybrid protein in which the carboxyl-terminal 32 amino acids of the B. subtilis SecA were replaced by the corresponding part of SecA from E. coli. In vitro pulldown experiments showed that, in contrast to B. subtilis SecA, the hybrid SecA protein gained the ability to efficiently bind to E. coli SecB, suggesting that the structural details of the extreme C-terminal region of SecA constitute a crucial SecB binding specificity determinant. Using a poorly exported mutant maltose binding protein (MalE11) and alkaline phosphatase (PhoA) as model proteins, we could demonstrate that the secretion of both proteins by B. subtilis was significantly enhanced in the presence of the artificial protein targeting pathway. Mutations in SecB that do not influence its chaperone activity but prevent its interaction with SecA abolished the secretion stimulation of both proteins, demonstrating that the implemented pathway in fact critically depends on the SecB targeting function. From a biotechnological view, our results open up a new strategy for the improvement of Gram-positive bacterial host systems for the secretory production of heterologous proteins.
Iterating a framework for the prevention of caregiver depression in dementia: a multi-method approach

ABSTRACT Background: Dementia caregiving is often stressful and depression in family caregivers is not uncommon. As caregiver depression can have significant effects, there is a need for preventive efforts which are consistent with the extensive literature. We sought to consolidate the wide range of evidence (using a multi-method approach) into a simple framework that can guide the prevention of caregiver depression. Methods: Using multiple logistic regression, we derived the predictors of caregiver depression from an empirical dataset containing key information and depression scores (based on the Center-for-Epidemiological-Studies-Depression-Scale) of 394 family caregivers. We then chose an underpinning theory as the foundation of the framework, and conducted an umbrella systematic review to find possible links between the derived predictors and the theory. Last, we compared the iterated framework with known interventions for caregiver depression in recent literature to assess whether the framework could map meaningfully with the known interventions. Results: Significant predictors of caregiver depression included primary caregiver (odds ratio, OR = 1.53), severe dementia (OR = 1.40), and behavioral problems (OR = 3.23), lower education (OR = 1.77), and spousal caregivers (OR = 1.98). The integrated framework derived focuses on four strategic areas: physical-care demands of persons with dementia (PWD), behavioral problems of PWD, caregiving competency, and loss and grief of caregivers. This framework is supported by known interventions for caregiver depression in recent literature. Conclusions: By consolidating a broad range of evidence, we iterated a framework to aid the understanding and prevention of caregiver depression in dementia. The framework offers an approach to prevention which is simple, systematic, and reflective of the extensive literature.
From Materialising to Memories: Design research to support personal remembering

Perhaps the term computer 'memory' has led people to believe that human memory has to be perfect and infallible. Many people worry when they realise they forget and some turn to recording and collecting as much as they can, e.g. photos or videos through life logging or personal data as seen in the quantified-self trend. Some people assume that by collecting they can avoid forgetting or at least have access to the information anytime later. And that is where they are wrong. First of all, recordings are not equivalent to memories, and memories 'can not be stored'. Secondly it has already been shown that people collect too much and organize too little for them to be able to find information later [1]. Thirdly, human memory works best when we forget. a lot. What I want to talk about is my vision [2] that we can use design research to support human remembering by supporting our memory's functions [3], which include a directive function (using the past to guide present and future thoughts and behaviours, e.g. solving problems), a self-representative function (creating a sense of self over time) and a social function (developing and nurturing relationships, through sharing of personal experiences). It is important to realise that in order to support these functions there is no need to improve our remembering capabilities, however it could benefit from the right type of support. Since remembering is a reconstructive process, individual memories are subject to change, continuously, and what someone experiences as a memory does not have to be the same as what happened or what other people remember from the experience. Bits of information from the original experience can be used to stimulate and facilitate the reconstruction process. These so-called memory cues [4], which can be anything: from a photo, a song to a person or a location, are at the core of our research. We use a people-centred approach to study memory cues in everyday life, which informs the design of interactive systems that present these memory cues. Since these cues are often digital, while people prefer material objects [e.g. 5], we combine material and digital in our studies and designs.
Activation of the interleukin‐10 gene in the human T lymphoma line HuT 78: identification and characterization of NF‐κ B binding sites in the regulatory region of the interleukin‐10 gene

Interleukin‐10 (IL‐10) is a pleiotropic cytokine which has potent inhibitory effects on macrophages and T cells, and contributes to the regulation of proliferation and differentiation of B cells. Resting HuT 78, a T‐cell line derived from a Sezary lymphoma, produced significant amounts of IL‐10 compared with another T‐cell line, Jurkat. To elucidate the mechanisms by which the IL‐10 is expressed, we have analyzed their activity in human T‐cell lines. We report here evidence that members of the family of transcription factors nuclear factor‐κ B (NF‐κ B)/Rel can specifically recognize 3 identical sequences located in the 5′‐regulatory region of IL‐10 gene in resting HuT 78 cells, whereas Jurkat cells expressed high levels of NF‐κ B consisting of p65 and p50 only upon activation with tumor necrosis factor‐α (TNF‐α). In HuT 78 cells, p50 was the major component in the NF‐κ B complexes. Exogenous TNF‐α and the monoclonal antibody to TNF‐α did not affect IL‐10 production and constitutive NF‐κ B binding levels in HuT 78 cells. This study is the first demonstration of a role for NF‐κ B in the IL‐10 gene expression, and suggests that its expression does not require TNF‐α. These novel findings may account for the specific IL‐10 gene expression in T cells.
Environmental Distribution, Analysis, and Toxicity of Organometal(loid) Compounds

ABSTRACT The biochemical modification of the metals and metalloids mercury, tin, arsenic, antimony, bismuth, selenium, and tellurium via formation of volatile metal hydrides and alkylated species (volatile and involatile) performs a fundamental role in determining the environmental processing of these elements. In most instances, the formation of such species increases the environmental mobility of the element, and can result in bioaccumulation in lipophilic environments. While inorganic forms of most of these compounds are well characterized (e.g., arsenic, mercury) and some of them exhibit low toxicity (e.g., tin, bismuth), the more lipid-soluble organometals can be highly toxic. Methylmercury poisoning (e.g., Minamata disease) and tumor development in rats after exposure to dimethylarsinic acid or tributyltin oxide are just some examples. Data on the genotoxicity (and the neurotoxicity) as well as the mechanisms of cellular action of organometal(loid) compounds are, however, scarce. Many studies have shown that the production of such organometal(loid) species is possible and likely whenever anaerobic conditions (at least on a microscale) are combined with available metal(loid)s and methyl donors in the presence of suitable organisms. Such anaerobic conditions can exist within natural environments (e.g., wetlands, pond sediments) as well as within anthropogenic environmental systems (e.g., waste disposal sites and sewage treatments plants). Some methylation can also take place under aerobic conditions. This article gives an overview about the environmental distribution of organometal(loid) compounds and the potential hazardous effects on animal and human health. Genotoxic effects in vivo and in vitro in particular are discussed.
Sixteen novel microsatellite markers developed for Dendrocalamus sinicus (Poaceae), the strongest woody bamboo in the world.

PREMISE OF THE STUDY Microsatellite primers were developed in the strongest and most economically important bamboo species, Dendrocalamus sinicus, to investigate its genetic variability. METHODS AND RESULTS Using the Fast Isolation by AFLP of Sequences COntaining Repeats (FIASCO) protocol, 16 polymorphic primer sets were identified within 24 individuals from two geographic locations. The number of alleles per locus ranged from two to four, with a mean of 2.6. The observed and expected heterozygosities varied from 0 to 1.000 and from 0.311 to 0.754, respectively. The cross-amplification of the 16 primer pairs was tested in four other Dendrocalamus species, and nine to 13 (56.3-81.3%) primer pairs were successfully amplified. CONCLUSIONS These markers will be useful for studies on the genetic diversity of D. sinicus, which may facilitate conservation of this species.
Extra-pulmonary and pulmonary tuberculosis in Hong Kong.

OBJECTIVE To compare the characteristics of patients with pulmonary and extra-pulmonary tuberculosis and to describe the organ involvement, diagnosis and treatment of extra-pulmonary tuberculosis. MATERIALS AND METHODS All patients with a diagnosis of tuberculosis treated by the Hong Kong Government Tuberculosis and Chest Service (Chest Service) in 1996 were studied. RESULTS Of the 5757 patients treated, 13.7% had extra-pulmonary tuberculosis alone and 8.6% had both extra-pulmonary tuberculosis and pulmonary tuberculosis. Extra-pulmonary tuberculosis was more common in women under 30 and over 75 years of age. Only six patients had human immunodeficiency virus (HIV) infection, of whom two had extra-pulmonary tuberculosis. The most common site of extra-pulmonary involvement was the pleura, followed by the lymph nodes. Miliary tuberculosis occurred in only 2.9%. Lymph node involvement occurred significantly higher in women, while pleural disease was significantly higher in men. The duration of treatment varied according to the site of disease, being shorter (6 months) for those with pleural disease only and >9 months for those with miliary, meningeal, gastrointestinal and genitourinary disease; 80.3% completed treatment at 12 months and 85.5% at 24 months. Of those who completed treatment, 1.4% had a relapse of disease at 24 months follow-up; there was no significant difference between those with pulmonary or extra-pulmonary disease. CONCLUSION In Hong Kong, extra-pulmonary tuberculosis is common, affecting 22.3% of TB patients, and is unrelated to HIV infection. There are sex differences in the organs most commonly affected. The rate of relapse of disease is low for those who completed treatment, irrespective of the site of involvement.
Access and stratification in Nordic higher education. A review of cross-cutting research themes and issues*

ABSTRACT The purpose of this review is to investigate cross-cutting research themes and issues related to access and stratification in Nordic higher education (H.E.) (Denmark, Iceland, Finland, Norway and Sweden). We synthesise how recent changes in H.E. policy, practise, and appropriations have influenced educational opportunities along social class, gender and age. In this review we highlight results and conclusions shared by various recent Nordic studies. The emphasis is on the common trends and patterns related to social stratification in access.