Miracle-dz/UniFAR-FTUs huggingface dataset:
miR-106a-5p Functions as a Tumor Suppressor by Targeting VEGFA in Renal Cell Carcinoma

MicroRNAs (miRNAs) regulate progression of different cancers. Nevertheless, there is limited information regarding the role of miR-106a-5p in renal cell carcinoma (RCC). Herein, we demonstrate that miR-106a-5p levels are drastically decreased in clear cell RCC (ccRCC) tissues and cell lines, which subsequently contribute to a poor patient overall survival and a high tumor stage. By screening and analyzing, we found that miR-106a-5p directly targets the 3′-UTR of the VEGFA mRNA and led to a decrease in VEGFA. This process is important for tumor cells' growth and colony formation, and overexpression of miR-106a-5p can especially kill kidney tumor cells. Therefore, our data reveal that miR-106a-5p functions as a tumor suppressor by regulating VEGFA and ccRCC may be susceptible to miR-106a-5p therapy.
Factors associated with successful completion of outpatient parenteral antibiotic therapy in an area with a high prevalence of multidrug-resistant bacteria: 30-day hospital admission and mortality rates

Objectives To identify factors associated with hospital admission and mortality within the first 30 days after enrolment in an outpatient parenteral antimicrobial therapy (OPAT) program, also analysing adequacy of the treatment regimen and clinical outcomes. Patients and methods This was a retrospective cohort study conducted between October 2016 and June 2017 in the state of São Paulo, Brazil. Variables related to hospital admission and mortality were subjected to bivariate analysis, and those with a P<0.05 were subjected to multivariate analysis as risk factors. Results We evaluated 276 patients, of whom 80.5% were ≥60 years of age and 69.9% had more than one comorbidity. Of the patients evaluated, 41.3% had pneumonia and 35.1% had a urinary tract infection. The most common etiological agent, isolated in 18 (31.6%) cases, was Klebsiella pneumoniae, and 13 (72,2%) strains were carbapenem resistant. The OPAT was in accordance with the culture results in 76.6% of the cases and with the institutional protocols in 76.4%. The majority (64.5%) of the patients were not admitted, and a cure or clinical improvement was achieved in 78.6%. Multivariate analysis showed that, within the first 30 days after enrolment, the absence of a physician office visit was a predictor of hospital admission (P<0.001) and mortality (P = 0.006). Conclusions This study demonstrated the viability of OPAT in elderly patients with pulmonary or urinary tract infections in an area with a high prevalence of multidrug-resistant bacteria and that a post-discharge physician office visit is protective against hospital admission and mortality.
The Use of System Dynamics Methodology in Building a COVID-19 Confirmed Case Model

Researchers used a hybrid model (a combination of health resource demand model and disease transmission model), Bayesian model, and susceptible-exposed-infectious-removed (SEIR) model to predict health service utilization and deaths and mixed-effect nonlinear regression. Further, they used the mixture model to predict the number of confirmed cases and deaths or to predict when the curve would flatten. In this article, we show, through scenarios developed using system dynamics methodology, besides close to real-world results, the detrimental effects of ignoring social distancing guidelines (in terms of the number of people infected, which decreased as the percentage of noncompliance decreased).
Histo- and clinico-pathological analysis of a large series of triple-negative breast cancer in a single center in China: Evidences on necessity of histological subtyping and grading

Objective To investigate histo-pathological distribution and clinico-pathological significance in a large Chinese triple-negative breast cancer (TNBC) patients serials based on the latest understanding of its clinico-pathological diversity, and to provide more information to clinicians to improve precision of individualized treatment of TNBC. Methods A retrospective analysis was performed on patients with TNBC at Breast Disease Center, Peking University First Hospital between January 2010 and December 2019. Histo- and clinico-pathological characteristics were analyzed by Chi-square test and Student’s t-test, and prognoses were calculated using Kaplan-Meier method and a Cox proportionate hazards model. Bonferroni correction was used to correct for multiple comparison. Results Conventional type of TNBC (cTNBC) were identified in 73.7% of 582 TNBC, while special type of TNBC (sTNBC) were 26.3%, including 71 apocrine carcinoma, 20 medullary carcinoma, 31 metaplastic carcinoma, 18 invasive lobular carcinoma, 7 invasive micropapillary carcinoma, 5 adenoid cystic carcinoma and 1 acinic cell carcinoma. Compared to sTNBC, cTNBC was associated with high histologic grade (P<0.001) and lower androgen receptor (AR) expression (P<0.001). TNM stage of low-grade cTNBC was significantly lower than that of high-grade cTNBC (P=0.002). Although no significant difference, there was a trend that the rate of 5-year disease-free survival (DFS) and 5-year overall survival (OS) were longer in high-grade cTNBC than in high-grade sTNBC (P=0.091 and 0.518), and were longer in low-grade sTNBC than in high-grade sTNBC (P=0.051 and 0.350). Metaplastic carcinomas showed larger tumor size (P=0.008) and higher proliferative Ki67 index (P=0.004) than cTNBCs. Conclusions Results from our cohort imply that sub-categorization or subtyping and histological grading could be meaningful in pathological evaluation of TNBC, and need to be clarified in more large collections of TNBC.
Détermination des visiteurs floraux de trois essences ligneuses à haute valeur commerciale : Baillonella Toxisperma Pierre, Afzelia Bipindensis Harms et Erythrophleum Suaveolens (Guill. & Perr.) Brenan

Pollination is at the bottom of sustainability and diversity of our ecosystems. However this ecosystemic service is threatened by human activities. The selective exploitation of tropical wood could alter cross pollination mecanisms by spacing out flowering species. This could improve selfing and drive an inbreeding depression. By this study we tried to identify pollinators of three main commercial woody species from Central Africa: Moabi Baillonella toxisperma Pierre, Doussié Afzelia bipindensis Harms and Tali Erythrophleum suaveolens (Guill. & Perr) Brenan. This research was carried out in FSC-certified forest concessions in southeastern Cameroon. A zoocentric approach was adopted in two stages: firstly, passive capture of insects by using three types of standardized traps (yellow traps, butterfly traps and light traps) in the flowering canopies of the three woody species; and secondly, check the presence of pollen grains of target species on insects. A total of 1.745 insects were collected from 8 Doussié, 6 Moabi and 3 Tali. Due to lack of time, and although a protocol was developed, Due to time constraints, palynological and specific analyses could not be performed although an effective protocol was put in place. Floral visitors were therefore determined at the family level, based on three characteristics: their morphology, their diet and the scientific literature. A total of 1745 insects were collected from 8 Doussié, 6 Moabi and 3 Tali. This number consisted of 1361 floral visitors of which 610 insects were captured on the Doussié for 35 families, 574 insects were captured on the Moabi for 37 families and 177 insects were captured on the Tali for 25 families. Although most of the floral visitors caught are similar for the three species (generalist pollinators), their distribution within the latter are significantly different, suggesting that some taxa are preferred for certain species. The main floral visitors to Doussie are mainly nocturnal insects with Coleoptera of the family Scarabeidae and Lepidoptera of the family Noctuidae and Sphingidae, and day floral visitors are Apidae and Syrphidae. Floral visitors to Moabi are both day and night visitors with mainly Lepidoptera of the family Nymphalidae and Noctuidae, Coleoptera of the family Scaradeidae and Elateridae, Diptera and Hymenoptera of the family Apidae. And the floral visitors of Tali are essentially Nocturnal Lepidoptera but the low sampling effort for this species does not allow us to affirm this status with certainty. The distances between the flowering plants calculated for each species after exploitation are 306 m for Doussié, 808 m for Moabi and 211 m for Tali. The comparison of these distances with the scientific literature seems to indicate that the selective exploitation has no impact on the dispersion of pollen.
Recruitment patterns and post-metamorphic attachment by the solitary ascidian, Ciona intestinalis (Linnaeus, 1767) in an invading population from Placentia Bay Newfoundland and Labrador

Ciona intestinalis (Linneaus, 1767) is a non-indigenous species discovered in Newfoundland (NL) in 2012. It is a bio-fouler with potential to cause environmental distress and economic strain for the aquaculture industry. Key in management of this species is site-specific knowledge of life history and ecology. This study defines the environmental tolerances, recruitment patterns, habitat preferences, and attachment behaviours of C. intestinalis in Newfoundland. Over two years of field work, settlement plates and surveys were used to determine recruitment patterns, which were correlated with environmental data. The recruitment season extended from mid June to late November. Laboratory experiments defined the growth rate and attachment behaviours of Ciona intestinalis. I found mean growth rates of 10.8% length·d⁻¹. The ability for C. intestinalis to undergo metamorphosis before substrate attachment, forming a feeding planktonic juvenile, thus increasing dispersal time was also found. These planktonic juveniles were then able to attach to available substrates post-metamorphosis.
Comparative Study on the Outcome of Stroke Patients Transferred by Doctor Helicopters and Ground Ambulances in South Korea: A Retrospective Controlled Study

The purpose of this study was to analyze the effectiveness of helicopter emergency medical services (HEMS) for its economic operations in South Korea. This study targeted stroke patients who were transported via HEMS or ground emergency medical services (GEMS) from the scene of an accident to a regional emergency medical center. From this patient population, stroke patients who traveled at least 50 km from the scene of the cerebral infarction to the hospital with analyzable outcome data were extracted and included in this study. This study included 26 HEMS and 102 GEMS stroke patients from a pool of 183 potential patients. The survival-to-discharge rate of patients transported via HEMS (96.2%; 25/26) was significantly higher than that of patients transported via GEMS (83.2%; 104/128) (P=0.001). The HEMS transfer was quicker with respect to the decision-making process because the emergency physician actively evaluates and communicates on-site and during in-transit travel to request an appointment immediately upon arrival at the emergency room. These results indicate that using HEMS increased discharge and survival rates and reduced in-hospital mortality of HEMS of stroke patients with a reduced admission time. This result association leads to reasonable cost-effectiveness and efficient estimates overall. In conclusion, HEMS indicate reduced time taken for stroke patients to be hospitalized and treated and decreased mortality after 24 hours. According to this result, HEMS transport can be more effective than GEMS in long-distance delivery of stroke patients.
The awareness of neglected tropical diseases in a sample of medical and nursing students in Cairo University, Egypt: A cross-sectional study

Neglected tropical diseases (NTDs) are a group of chronic diseases affecting 1.2 billion people worldwide, with more burden in the developing communities. Improving awareness about NTDs is a powerful affordable long-term intervention for infection control. In literature, there is a limited number of studies in the developing countries assessing the awareness of healthcare providers regarding these diseases. The present study aimed at assessing the awareness of a sample of Cairo University medical and nursing students regarding NTDs. A cross-sectional descriptive study was conducted on 184 medical and nursing students in Cairo University. An anonymous self-administered questionnaire in English language with an estimated completion time of 15 minutes was used for evaluation. It included question categories which cover the knowledge about NTDs and control measures as well as the willingness to participate in NTDs control activities. Content analysis was performed on the materials and specifications of the epidemiology course given to medical and nursing students. Out of the study participants, 26% knew the meaning of NTDs. The main source of their knowledge was social media followed by the epidemiology course. A percentage of 33% of the students agreed that NTDs are of public health importance in Egypt. Thirty four percent of the participants expressed their willingness to participate in control activities for NTDs. Comparing medical and nursing students, a higher percentage of the nursing students stated that NTDs are causing a public health problem in Egypt with a statistically significant difference (P value < 0.001), while a statistically significant higher percentage of medical students believed that the awareness level regarding NTDs in Egypt is low (P value = 0.002). Cairo University medical and nursing students in this study showed a gap in the level of knowledge regarding NTDs and their control activities which represents a great threat to the control of these diseases.
New classification of intrinsic disorder in the Human proteome

We propose a new, sequence-only, classification of intrinsically disordered human proteins which is based on two parameters: dr, the percentage of disordered residues, and Ld, the length of the longest disordered segment in the sequence. Depending on dr and Ld, we distinguish five variants: i) ordered proteins (ORDs); ii) not disordered proteins (NDPsj; (iii) proteins with intrinsically disordered regions (PDRs); iv) intrinsically disordered proteins (IDPs) and v) proteins with fragmented disorder (FRAGs). PDRs have been considered in the general category of intrinsically disordered proteins for a long time. We show that PDRs are closer to globular, ordered proteins (ORDs and NDPs) than to disordered ones (IDPs), both in amino acid composition and functionally. Moreover, NDPs and PDRs are uniformly spread over several functional protein classes, whereas IDPs are concentrated only on two, namely nucleic acid binding proteins and transcription factors, which are just a subset of the functions that are commonly associated with protein intrinsic disorder. As a conclusion, PDRs and IDPs should be considered, in future classifications, as distinct variants of disordered proteins, with different physical-chemical properties and functional spectra.
Northern exposure: Intergrating disaster management in a humanitarian and community studies program in the Northern Territory of Australia

This paper outlines a novel approach to preparing students for practising in situations of emergency and disaster management. The teaching approach and curriculum design uses an intensive which takes the form of an extended simulation of a disaster necessitating the establishment of a displaced persons’ camp. In higher education, extended simulation is an under-utilised teaching technique that is rarely included in social work curricula. The example is given of how social work and humanitarian studies programs embed a live simulation in order to teach students disaster management competencies. This experience provides team and individual learning experiences which involve the application of practical survival skills involved in setting up sanitation systems, obtaining food and medication supplies, using four-wheel-drive vehicles and horse handling. These skills promote work readiness when students go out to work in both rural and remote communities in Australia and internationally. Principles of reflective practice, teamwork and disaster/trauma response are embedded in a “community of learning” model. The implications for teaching and learning are outlined.
The growth performances and the gut health parameters of Sentul chickens supplemented with various dosage of turmeric powder

Asmara IY, Widjastuti T, Setiawan I, Abun, Partasasmita P. 2018. The growth performances and the gut health parameters of Sentul chickens supplemented with various dosage of turmeric powder. Nusantara Bioscience 10: 121-125. The aim of this study was to investigate the effect of different levels of turmeric powder (0, 1, 2, 3 g/kg) on production performance and the number of Escherichia coli and Staphylococcus aureus bacteria in the intestine of Sentul chickens. The results showed that addition of 3 g/kg of turmeric powder to diet significantly reduced feed intake (FI) and improved feed conversion ratio (FCR) of Sentul Chickens aged 9-16 weeks. The birds fed with control diet had the highest number of S. aureus and E. coli, while the birds fed with the diets added with 2 and 3 g/kg turmeric powder had the lowest number of bacteria. The study reveals that increasing levels of turmeric powder in diets had positive effects on bird’s performance and the number of intestinal bacteria. It can be concluded that a level of 3 g/kg turmeric powder in diets gave the best result due to significantly improved FCR.
The Forgotten Side of Partisanship: Negative Party Identification in Four Anglo-American Democracies (forthcoming, Comparative Political Studies, November 2014)

Early studies of electoral behavior proposed that party identification could be negative as well as positive. Over time, though, the concept became mostly understood as a positive construct. The few studies that took negative identification into account tended to portray it as a marginal factor that went “hand-in-hand” with positive preferences. Recent scholarship in psychology reaffirms, however, that negative evaluations are not simply the bipolar opposite of positive ones. This article considers negative party identification from this standpoint, and evaluates its impact in recent national elections in Australia, Canada, New Zealand, and the United States. Our findings highlight the autonomous power of negative partisanship. They indicate as well that ideology has an influence on both positive and negative partisan identification. The Forgotten Side of Partisanship: Negative Party Identification in Four Anglo-American Democracies In April 2002, the first round of the French presidential election produced a political earthquake. Undermined by a high level of abstention and by the fragmentation of the left, the socialist candidate, Lionel Jospin, finished third, leaving conservative Jacques Chirac and farright leader Jean-Marie Le Pen to fight for the presidency in the second round (Miguet, 2002). Shocked, voters from the left mobilized to prevent the worst, and they rallied under an unlikely call to “vote for the crook, not the fascist” (Hayter, 2002). For these voters, the reasons to cast a ballot appeared purely negative. Their motives were nevertheless powerful, and the participation rate increased significantly in the second round. This atypical development indicates how negative motivations can influence voters’ decisions. Yet, relatively little is known about such negative views. Even though the early, and seminal, studies of electoral behavior proposed that party identification could be negative as well as positive (see, notably, Campbell et al., 1960: 122-36), over time the concept became mostly understood as a positive construct (Vlachova, 2001: 483; Garry, 2007: 348). The possibility that party identification could be multidimensional and that positive and negative evaluations may not be correlated was acknowledged (Weisberg, 1980), but the few studies that took negative political attachment into account tended to portray it as a factor that only became relevant in exceptional situations (Rose and Mishler, 1998), or as an underlying dimension of party identification that probably went “hand-in-hand” with a preference for a given party (Greene, 1999: 395; see also Maggiotto and Piererson, 1977).
An enhanced biometrics-based remote user authentication scheme using smart cards

Authentication and key exchange are fundamental techniques for enabling secure communication over mobile networks. In order to reduce implementation complexity and achieve computation efficiency, design issues for efficient and secure biometrics-based remote user authentication scheme have been extensively investigated by research community in these years. Recently, two biometrics-based authentication schemes using smart cards are introduced by Li and Hwang and Li et al., respectively. Li and Hwang proposed an efficient biometrics-based remote user authentication scheme using smart card and Li et al. proposed an improvement. The authors of both schemes claimed that their protocols deliver the important security features and system functionalities, such as without synchronized clock, freely changes password, mutual authentication, as well as low computation costs. However, these two schemes still have much space for security enhancement. In this paper, we first demonstrate a series of vulnerabilities on these two schemes. Then, an enhanced scheme with corresponding remedies is proposed to eliminate all identified security flaws in both schemes.
Alguns procedimentos e estratégias para lidar com a resistência ao uso de novas tecnologias: uma revisão da literatura

A implementacao de uma inovacao relacionada com uma aplicacao informatica numa organizacao tem como reflexo manifestacoes de resistencia por parte dos utilizadores, que podem ser catalogadas de diversas formas e causar mau estar na organizacao se nao forem percebidas. Deve existir um empenho por parte dos decisores organizacionais para as diluir. A resistencia tem sido apresentada e discutida como um dos mais frequentes motivos para se tomarem medidas importantes aquando da implementacao de inovacoes. Estas medidas podem ser desencadeadas previamente, no momento de implementacao ou delineadas como accoes pos-implementacao. E importante que em cada organizacao, conhecedora do ambiente organizacional e do perfil dos potenciais utilizadores da nova tecnologia, se esboce um plano estrategico com as possiveis accoes para que exista sucesso de utilizacao. Neste documento apresentamos uma revisao da literatura acerca da resistencia e estrategias para a combater nas diferentes fases de implementacao de tecnologias de informacao.
Oral Medicine 10. Pigmentaties van het mondslijmvlies.

Pigmented oral lesions may be due to the most diverse disorders. A distinction can be made between non-melanin-associated and melanin-associated pigmentations. Some lesions may be diagnosed on the basis of medical history and clinical research. In focal pigmented lesions, histological examination is necessary to establish a definitive diagnosis. Most disorders are benign but some may be malignant melanomas.
In-vitro antidermatophytic activity of essential oil of Psidium guajava (Linn.)

Dermatophyte with the ability to digest keratine invade and therve on keratinized of human and animals. In the present study, the activity of essential oil of Psidium guajava (Linn.) was evaluated against four selected dermatophytes, namely Microsporiumcanis, Trichophytomruburum, T. verrucossum, T. tonsurans. Dermatophyteswere isolated with the infected skin, scalp, nail and genital organs of patients from districts hospital, Bareilly. Griseofulvin was used as a standard antifungal drug against the test dermatophytes. Oil was extracted through clevenger’s apparatus. Maximum inhibition zone was reported 69 mm against T. verrucossum followed by 60 mm Trichophytomruburum, 48 mm Trichophytomruburum and 45mm Microsporiumcanis. All five concentrations of oil showed excellent inhibitory effect against all test dermatophytes as compared to standard antifungal used.