Miracle-dz/UniFAR-FTUs huggingface dataset:
Técnica de recambio de electrodo percutáneo disfuncional para estimulación medular como tratamiento del dolor crónico refractario en paciente con schwannoma de raíz L2 izquierda: reporte de un caso

espanolIntroduccion: Los sistemas de estimulacion medular espinal pueden utilizar electrodos percutaneos (EP) o paletas percutaneas, a diferencia de los electrodos quirurgicos que se requiere un abordaje quirurgico para su implantacion mediante laminotomia o laminectomia. Hasta la fecha no existen reportes en la literatura mundial acerca del retiro percutaneo de EP disfuncional. Materiales y metodos: Es un reporte de caso, descriptivo y retrospectivo, que ha requerido de colocacion de Neuroestimulador Medular Implantable (NEMI) con EP por dolor neuropatico cronico refractario, que curso con disfuncion y posteriormente candidato para recambio del EP con tecnica percutanea. Realizado en el servicio de Clinica del Dolor del Centro Medico Nacional "20 de Noviembre" en el mes de septiembre de 2016. Resultados: Paciente de sexo femenino de 54 anos con diagnostico de schwannoma de raiz L2 izquierda, que presento disfuncion del EP del NEMI durante accidente automovilistico. Se realizo abordaje percutaneo en sala de fluoroscopia mediante el uso del EpiducerTM de ST. Jude Medical como "puente" para el retiro del EP disfuncional y recolocacion del nuevo EP sin realizar abordaje por laminotomia o laminectomia. Conclusiones: El abordaje percutaneo para recambio de EP es una tecnica efectiva minimamente invasiva, con menor probabilidad de complicaciones y sin necesidad de realizar laminectomia o laminotomia. EnglishIntroduction: Spinal cord stimulation systems can use percutaneous electrodes or percutaneous (PP) paddles, unlike surgical paddles that require a surgical approach for implantation by laminotomy or laminectomy. To date, there are no reports in the world literature regarding percutaneous withdrawal of dysfunctional (PP). Materials and methods: It is a case report, descriptive and retrospective. Who required implantation of implanted medullary neurostimulator (NEMI) with (PP) for refractory chronic neuropathic pain, who attended with dysfunction and later candidate for replacement of the (PP) with percutaneous technique. Performed in service of Pain Clinic of the National Medical Center "November 20" in September 2016. Results: A 54-year-old female with a diagnosis of Schwannoma of the left L2 root who presented dysfunction of the (PP) of the (NEMI) during an automobile accident. A percutaneous approach is performed in a fluoroscopy room using the Epiducer TM of ST. Jude Medical as a "bridge" for the removal of the dysfunctional (PP) and replacement of the new (PP) without conducting a laminotomy or laminectomy approach. Conclusions: The percutaneous approach to replacement of (PP) is an effective minimally invasive technique, with a lower probability of complications and without the need for laminectomy or laminotomy.
Mobile User Interface for a patient-centered health care application

Low back pain is a prevalent issue in the developed world as people adopt a more sedentary lifestyle. This thesis gives insight to available interactive health communication applications for self-managing non-specific low back pain, with the main focus on mobile delivered interventions. The aim of this thesis was to conceptualize and prototype a mobile user interface for the decision support system selfBACK which is providing an interactive self-management program for non-specific low back pain. We conducted three workshops with a multidisciplinary group of people specialising in technology, medicine and user experience design. The outcome of this process was the initial sketches of the conceptual design. After this we conducted a review of existing solutions in found in literature and a review of commercial mobile apps. Finally, all the ideas from the workshops and existing solutions were brought together in a complete design proposal. In order to conduct experiments to validate the design, we implemented both a native Android and iOS prototype which is communicating with a restful backend server. The prototyped allowed us to conduct the user test with a survey of non-implemented functionality, a usability test of the implemented components and a post-test questionnaire. The participants were five eligible testers having suffered from back pain. The results and feedback from the user test were compared to previous research, and finally we present suggestions for improvements to design proposal.
The Role of Consumers’ Perceived Security, Perceived Control, Interface Design Features, and Conscientiousness in Continuous Use of Mobile Payment Services

Mobile payment has played a vital role in transforming traditional payment methods into digital payment methods and has led to changes in consumers’ behaviors in economic exchanges. However, there is a lack of knowledge about how perceived security influences are a sustainable use of mobile payment services. In order to examine the impact of perceived security on users’ continuous use, especially regarding mobile payment services and factors related to perceived security (i.e., perceived control, interface design features, and conscientiousness), an empirical study was conducted to collect data from 252 participants. Then, the proposed research model was examined using structural equation modelling. The results revealed that the perception of interface design features was influenced by conscientiousness. Perceived security was affected by perceived control, the perception of interface design features, and conscientiousness. Moreover, perceived security was identified to have a strong impact on continuous intention to use mobile payment. The design implications for mobile service providers and designers are presented.
False Passage Mass due to Broken Probe after Nasolacrimal Duct Probing: A Case Report

Purpose: To report a patient with retained broken probe tip in the false passage site after nasolacrimal duct (NLD) probing Case report: A 18-month-baby with epiphora and a nontender mass in the site of lacrimal sac was visited in clinic. She had a history of probing six months ago by another ophthalmologist. The probing was repeated successfully but the mass size didn’t change. The mass was dissected and small size whitish color mass was completely removed. In pathologist report, there was a metallic foreign body (5 mm × 0.3 mm) in the center of the mass. The foreign body was due to probe breaking and its tip being retained in the false passage site. Conclusion: This case report shows the importance of gentle probing and notification to integrity of the probe before and after the procedure.
Frequency of Dengue Fever in Children Presenting with Hepatomegaly and Elevated SGPT Level

Objective: To determine the frequency of Dengue fever in children presenting with Hepatomegaly and elevated SGPT level. Study Design: Cross sectional study. Duration of Study: March 2016 to August 2016. Setting: Department of Pediatric Medicine Unit-1, Allied Hospital, Faisalabad. Methodology: Over 6 months, 91 children meeting the inclusion criteria were selected from OPD and ward after parental informed consent. Laboratory investigations included Complete Blood Count with peripheral film for Malarial Parasite, SGPT level, IgM and IgG typhoid antibodies, Hepatitis A by ELISA, Hepatitis B and C. Patients were thoroughly evaluated by detailed history and clinical examination. Ultrasonography of the patients was performed to confirm the presence of hepatomegaly. After 5 days 2cc blood for IgM and IgG dengue antibodies were sent to pathology laboratory. Finally, the data were analyzed to determine the mean and standard deviation for quantitative variable like age of child, duration of fever and SGPT level. Qualitative variable like sex and presence of Dengue Fever were presented as frequency and percentage. Results: Age distribution of the patients was done which shows that 59.34% were between 1-7 years and 40.66% were between 8-14 years of age, mean+SD was calculated as 7.02+4.05 years. Mean SGPT levels were recorded as 58.32+6.43. Frequency of dengue fever in children presenting with hepatomegaly and elevated SGPT level was recorded in 72.53%. Conclusion: We concluded that the frequency of Dengue fever in children is high among patients presenting with hepatomegaly with elevated SGPT levels. Therefore, it is recommended that every child who presents with hepatomegaly and elevated SGPT levels might also be elevated for Dengue fever in dengue endemic areas.
Workplace violence in the emergency department in India and the United States

Background: Internationally, emergency medicine (EM) physicians are vulnerable to both physical and verbal violence. Few studies have examined or compared perceptions and the impacts of workplace violence in India and the United States (US). Objectives: To assess the perceived incidence of workplace violence and its implications on sleep, missed days of work, fear in the workplace, and overall job satisfaction. Materials and Methods: This was an anonymous, prospective, cross-sectional electronic survey of EM residents and physicians. A cohort of physicians in the US was matched to a cohort of physicians in India. Results: Overall, 286 physicians were eligible to participate, 177 responded (98 people from the US and 79 from Indian, for a 62% total response rate). In the US 100% of respondents witnessed verbal violence, whereas only 23% of verbal abuse cases were reported. In India, 89% of respondents witnessed verbal abuse, 46% of cases were reported. Respondents in the US both witnessed and experienced significantly more verbal and physical abuse (P < 0.001). Despite the differences in perceived rates of violence, there were no significant differences between country cohorts regarding the consequences of these incidents. This includes self-reported sleep, missed days of work, and fear of going to the workplace. US respondents were less satisfied with their jobs due to workplace violence as compared to their Indian colleagues (P = 0.041). Conclusion: ED workplace violence is common internationally, underreported, and results in poor job satisfaction, workplace fear, and loss of sleep. The following core competencies are addressed in this article: Patient care, Professionalism, Systems-based practice.
Livets sluttfase - om å finne passende behandlingsnivå og behandlingsintensitet for alvorlig syke og døende

på hvordan man kan forbedre beslutningsprosessene knyttet til begrensning av medisinsk behandling i livets sluttfase slik at overbehandling kan unngås. Selv om deler av forskningsgrunnlaget for konklusjonene i denne rapporten er svakt, ser det ut til at: • Kulturelle, etniske, religiøse og sosioøkonomiske faktorer i tillegg til diagnose, sivilstatus, alder, kjønn og erfaring kan medvirke i beslutninger om medisinsk behandling og omsorg i livets sluttfase og på pasientenes behov for informasjon og medvirkning i beslutningsprosessen. • Et fl ertall av pasienter med alvorlig sykdom gir uttrykk for at de ønsker å være informert om sin sykdom og prognose, og diskutere spørsmål knyttet til behandling og omsorg i livets sluttfase. Ofte blir ikke dette godt nok ivaretatt, og kjennskapen til pasientenes preferanser kan være mangelfull. • Prognostisk verktøy i tillegg til klinisk vurdering, kjennskap til pasientens preferanser, tverrfaglig samarbeid, gode kommunikasjonsferdigheter og kompetanse innen etikk og Livets sluttfase om å fi nne passende behandlingsnivå og behandlingsintensitet for alvorlig syke og døende
Original research article Contraceptives and cerebral thrombosis: a five-year national case-control study

The object of this study was to assess the influence of oral contraceptives (OCs) on the risk of cerebral thromboembolic attacks (CTA) including thrombotic stroke and transitory cerebral ischemic attacks. A 5-year case-control study including all Danish hospitals was conducted. All women 15‐ 44 years old suffering a first ever CTA during the period January 1, 1994 to December 31, 1998, were included. Controls were selected annually, 600 per year in 1994 ‐1995, 1200 per year 1996 ‐1998. Response rates for cases and controls were 88% and 90%, respectively. After exclusion of nonvalid diagnoses, pregnant women, and women with previous thrombotic diseases, 626 cases and 4054 controls were available for analysis. A multivariate matched analysis was performed. Controls were matched to cases within 1-year age bands. Adjustments were made for the following potential confounders: year, length of OC use, smoking, hypertension, migraine, family CTA, and years of schooling. There were 212 and 1208 current users of OCs among cases and controls, respectively. The risk of CTA among current users of OCs decreased significantly with decreasing estrogen dose (nonusers reference): OCs with 50 g, 30 ‐ 40g, 20 g ethinyl estradiol (EE) and progestin-only pills implied adjusted odds ratios (ORs) (95% CI) of 4.5 (2.6 ‐7.7), 1.6 (1.3‐2.0), 1.7 (1.0 ‐3.1), and 1.0 (0.3‐3.0), respectively. Current users of OCs with second- (levonorgestrel or norgestimate) and third(desogestrel or gestodene) generation progestins combined with 20 ‐30 g EE had ORs of CTA of 2.2 (1.6 ‐3.0) and 1.4 (1.0 ‐1.9), respectively. After correction for differences in estrogen dose, the third- to second-generation risk ratio was 0.6 (0.4 ‐ 0.9; p 0.01). In conclusion, high dose OCs and OCs with second-generation progestins were associated with the risk of CTA. The risk increased 2.5 times with estrogen dose increasing from 20 to 50 g EE, and users of low-dose OCs with second-generation progestins had a 61% higher risk-association of CTA than users of OCs with third-generation progestins. © 2002 Elsevier Science Inc. All rights reserved.
Aceites esenciales, obesidad y diabetes tipo 2

The increase of obesity in our society has become evident nowadays. Recent statistics from official entities place it within the most prevalent diseases in the world. Obesity is a chronic pro-inflammatory disease that causes an imbalance in endocrine activity of adipose tissue, changing the production pattern of certain adipocytokines related to insulin resistance, consequently there is an increase of glycemia characteristic in type 2 diabetes mellitus. The treatment for these disorders is aimed to lower bloodsugar levels and reduce the weight of those who suffer it. The medicines used to treat both diseases usually have undesirable side effects, which have made pharmacologists be in constant search for new drugs. The aim of this publication is to review the state of the art on these two diseases, starting from the fact that both have in common mild systemic inflammation and immunological alterations that lead to resistance to insulin action, and additionally to describe the activity of some essential oils studied so far in rats and mice as possible therapeutic alternatives in controlling obesity and type 2 diabetes mellitus.
SLIT2 Prevents Renal Ischemia Reperfusion Injury in Mice

The Slit family of secreted proteins act as axonal repellents during embryogenesis. Slit2 via its receptor, Roundabout-1, also inhibits chemotaxis of multiple leukocyte subsets. Using static and microfluidic shear assays, we found that Slit2 inhibited multiple steps required to recruit circulating neutrophils. Slit2 blocked capture and firm adhesion of human neutrophils to and transmigration across inflamed primary vascular endothelial cells. To determine the response of Slit2 in renal ischemia reperfsuion injury, Slit2 was administered prior to bilateral renal pedicle clamping in mice. This led to significant decreases in both renal tubular necrosis score and neutrophil infiltration. Administration of Slit2 also prevented elevation of plasma creatinine following injury in a dose-dependent manner. Furthermore, administration of Slit2 did not increase hepatic bacterial load in mice infected with L.monocytogenes infection. Collectively, these data demonstrate Slit2 as an exciting therapeutic molecule to combat renal ischemia reperfusion injury without compromising protective host innate immune functions.
Scheme Construction of VR Cloud Integration Intelligent System Based on Internet of Things

With the rapid development of mobile Internet and intelligent terminals, the privacy data generated by mobile applications is increasing. Because of the limited computing and storage capacity of mobile intelligent terminals, the security measures designed for traditional network terminal devices are not suitable for mobile intelligent terminals. This paper analyses the current application situation of virtual reality technology and Internet of Things technology and the bottleneck of engineering application and popularization, and probes into relevant problems. On this basis, a new model of intelligent system based on virtual reality and Internet of Things is proposed. The extended Spice protocol provides efficient support for front-end separation of displays and calculations. The encryption master key is generated by splicing the keys generated by the authentication cloud and the mobile intelligent terminal, and the master key is used to effectively prevent the mobile intelligent terminal and the cloud storage server from leaking the privacy data of the mobile user. Realize the unified management, flexible deployment, flexible delivery and automatic operation and maintenance of basic resources, and promote the transformation of application deployment from applying for equipment to applying for service.
Secondary Vulvodynia Patients Show Reduced Bacterial Diversity in Vestibular Microbiome

Introduction: Localized Provoked Vulvodynia (LPV) is a quite common form of sexual pain among young women. Primary LPV (e.g. pain from the first attempted intercourse) and secondary LPV (pain-free time period before the initiation of symptoms) have been suggested to develop via different pathomechanisms. As inflammation is one possible trigger in LPV, changes in vaginal and/or vulvar microbiome may be an initiator of the inflammatory process leading to peripheral neurosensitization and predisposing women to LPV. Aim: Aim of this pilot study was to find out, whether there are differences in vestibular microbiome between LPV patients and controls. Materials and Methods: Thirty women with LPV (8 with primary and 22 with secondary LPV) and 21 controls were prospectively recruited to the study from Kanta-Hame Central Hospital and Tampere University Hospital (TAUH). Paired vestibular samples were collected in clinical outpatient setting and analyzed with 16s rRNA sequencing. Results: LPV patients had lower BMI, were younger and more often nulliparous than controls. Patients with secondary vulvodynia had reduced (p = 0.06) bacterial species diversity (alpha diversity) and more clustered (p= 0.05) vaginal microbiome community (beta diversity) compared to healthy controls. Differential abundance analysis identified 31 bacterial taxa that contributed to the difference in bacterial composition between secondary cases and controls (p < 0.05). Bacteria taxa that were increased among patients were Gardneralla vaginalis (p<0.0001), Peptoniphilus spp (p<0.0001), Prevotella amnii (p<0.0001) and Streptococcus spp (p=0.0001). Several bacterial species were more abundant among healthy controls reflecting reduced bacterial diversity among patients. Conclusion: In patients with secondary LPV changes in vulvar microbiome may contribute to pathogenesis of LPV and ultimately lead to targeted therapeutic options. These preliminary findings need to be confirmed in a larger study.
Musculoskeletal Injuries in British Army Recruits: A Retrospective Study of Incidence and Training Outcome in Different Infantry Regiments Over Five Consecutive Training Years

Background: Musculoskeletal training injuries represent a considerable socio economic burden with far reaching implications on organisational effectiveness. Injury data analysis is fundamental to understanding the magnitude of the problem and underpins the subsequent design and delivery of targeted prevention strategies. Aim: To evaluate five years inter-regimental musculoskeletal injury patterns and training outcomes in British infantry recruits. Methods: This was a descriptive retrospective observational study of 4777 MSKI reported from a total of 12501 British Infantry recruits over five consecutive training years (1st April 2012-31th March 2017). The observed cohorts comprised of recruits from the Parachute Regiment (n=1910), Line Infantry (n=7799), Guards (n=1834) and the Gurkha Regiment (n=958). The physiotherapy Department collected the injury data throughout consecutive phase 1 and phase 2 training, the Combat Infantryman Course (CIC). Results: The five year cumulative incidence varied between the individual training regiments; 66.49% (95% CI: 64.39-68.62), 38.17% (95% CI: 35.97-40.42) 33.29% (95% CI: 32.22-34.31) and 22.03% (95% CI: 19.42-24.65) for Parachute, Guards, Line, and Gurkha respectively. Overuse injuries were the most frequently observed subclassification whilst the most common site for all types of injury was the knee. Significant difference was found (p week 13). 42.1% of the total injuries accounted for within the first eight weeks of training. Training outcomes, recruits successfully completing training at the first attempt were found to be significantly different (p<0.01); 37.0% (Parachute), 53.1% (Guards), 64.6% (Line) and 98.42% (Gurkha). Conclusions: The wide range in the incidence of MSKI and training outcomes across the four Infantry training Regiments, suggests that there is a requirement to thoroughly investigate the content and delivery of training within the CIC as well as the impact of the introduction of an integrated injury prevention strategy-Project OMEGA.
The role of altered fatty acid metabolism in cardiomyopathy and heart failure : an in vivo magnetic resonance imaging and spectroscopy approach

• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.
The serious business of instructional humor outside the classroom: a study of elite gymnastic coaches’ uses of humor during training

ABSTRACT This study documents the use of humor in an instructional setting outside traditional classrooms. Specifically, it studied the use of instructional humor in training elite and aspiring gymnasts. Analysis of practice recordings, firsthand observations, and interviews with coaches, staff members, athletes and their guardians, revealed that coaches employed instructional humor in patterned ways and at patterned times to encourage the learning process. This study is the first to document that coaches used humor to address athletes’ potential identity harm due to failure during practice (labeled here, ‘identity distracting function’) and to reaffirm athletes’ relational standing with coaches and peers in spite of those failures (labeled here, ‘relational reaffirmation function’). The study also identified situations in which humor is inappropriate during training. Thus, this study identified new functions of instructional humor used during the learning process for aspiring elite athletes. The transferability of findings to other settings is also described.