Miracle-dz/UniFAR-FTUs huggingface dataset:
Cost–effectiveness of linezolid in methicillin-resistant Staphylococcus aureus skin and skin structure infections

Linezolid is a novel oxazolidinone antibacterial agent with a broad clinical application, especially in methicillin-resistant Staphylococcus aureus skin and soft-tissue infections and skin and skin-structure infections. Pharmacoeconomic advantages include decreased hospital duration, reduction in intravenous antibiotic use and early discharge opportunities that contribute to an overall reduction in healthcare resources. Linezolid’s oral formulation has a pharmacokinetic profile that is similar to its intravenous formulation, which creates opportunities for early discharge not available to comparators like vancomycin and daptomycin. Both vancomycin and daptomycin require intravenous therapy, which compounds the resources required in treating methicillin-resistant S. aureus skin and soft tissue/skin and skin structure infections. Pharmacoeconomic studies have demonstrated an overall reduction in total direct costs to the payer in favor of linezolid over its comparators. Its overall reduction in healthcare utilization makes it an appropriate alternative to the standard therapy, vancomycin.
Submucosal Diathermy of the Inferior Turbinates

IN this article we describe a method of treating nasal obstruction due to engorgement of the inferior turbinates by means of unipolar submucosal diathermy. The results of treatment in a series of a hundred cases are given. These cases represent a large and often depressing section of rhinological practice. They fill the surgeries and and their of the industry.
A proposal for revision of hemicrania continua diagnostic criteria based on critical analysis of 62 patients

Background: Misdiagnosis of hemicrania continua (HC) is common. It is diagnosed according to the criteria of the International Headache Society (IHS), but in clinical practice, these criteria seem too restrictive and many hemicrania continua-like headaches remain unclassified. Subjects and methods: We retrospectively studied the patients fulfilling the IHS criteria for HC. In addition, we identified a group of patients who met all criteria minus cranial autonomic features (HC-A) or minus a complete response to indomethacin (HC-I). We compared epidemiological profiles, clinical features and therapeutic responses to drug(s) between the groups. In addition, we reviewed the literature and critically analysed the diagnostic criteria for HC. Results: Sixty-two patients with a putative diagnosis of HC were identified. Thirty patients (48%) fulfilled the IHS criteria for HC. Thirty-two (52%) patients failed to satisfy one of the features of HC. Thirteen patients (21%) did not show any evidence of cranial autonomic feature during the episodes of the exacerbations (HC-A). Another 19 patients (31%) did not show a complete response to indomethacin (HC-I). Epidemiological and clinical features of all three groups were compared. None of the differences were statistically significant. In review of the literature, we noted that cranial autonomic features, a sense of restlessness/agitation during exacerbations, and response to indomethacin (marked to complete) are the specific features of HC. However, these features may not all be present in all cases. Conclusion: Present diagnostic criteria are too restrictive. We suggest adding the site of pain in the criteria, as described for trigeminal autonomic cephalalgias. Cranial autonomic features, a sense of restlessness during exacerbations, and marked to complete response to indomethacin are three characteristics features of HC. We suggest that the presence of any two may be sufficient to diagnose HC.
Monitoring for environmental mutagenesis in wild animals - lessons from human studies

The increasing realisation that environmental monitoring practices need to demonstrate radiological protection of the whole ecosystem has led to suggestions that genotoxic techniques derived from human monitoring of radiation exposure could be applied to other animal species. Human studies have highlighted the need to establish the relationship between exposure, genetic effect and biological consequence so that different study objectives, e.g. hazard identification, dose estimation, risk evaluation, can be addressed by the application of the most appropriate and informative assay.
NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response.

BACKGROUND & AIMS The role of nuclear factor kappaB (NF-kappaB) activation in acute pancreatitis is uncertain. The transcription factor NF-kappaB is activated early in acute pancreatitis, and NF-kappaB is widely considered a key element in inflammatory responses based on its ability to regulate the expression of inflammatory mediators in vitro. However, its role in vivo in specific diseases remains unclear, and the current data on the role of NF-kappaB in acute pancreatitis is primarily correlative. METHODS In this study, NF-kappaB was directly activated within the pancreas using adenoviral-mediated transfer of an active subunit, RelA/p65 (Adp65), delivered by intraductal injection. RESULTS Administration of Adp65 led to the infection of a population of acinar cells within the pancreas, the activation of NF-kappaB, the expression of NF-kappaB target genes, and an inflammatory response. Administration of Adp65 increased the infiltration of neutrophils to the pancreas and lung and caused widespread damage to pancreatic acinar cells. In contrast, at the same titer, control adenovirus (AdGFP) had no effect on these parameters. The level of NF-kappaB activation and the severity of inflammation were reduced when an adenovirus bearing the inhibitory subunit IkappaB-alpha was coadministered with Adp65. CONCLUSIONS Thus, activation of NF-kappaB within the pancreas was sufficient for the initiation of an inflammatory response in this model. These results help define the specific role of NF-kappaB activation in acute pancreatitis.
The Pipsqueak Protein of Drosophila melanogasterBinds to GAGA Sequences through a Novel DNA-binding Domain*

Pipsqueak (Psq) belongs to a family of proteins defined by a phylogenetically old protein-protein interaction motif. Like the GAGA factor and other members of this family, Psq is an important developmental regulator in Drosophila, having pleiotropic functions during oogenesis, embryonic pattern formation, and adult development. The GAGA factor controls the transcriptional activation of homeotic genes and other genes by binding to control elements containing the GAGAG consensus motif. Binding is associated with formation of an open chromatin structure that makes the control regions accessible to transcriptional activators. We show here that Psq contains a novel DNA-binding domain, which binds, like the GAGA factor zinc finger DNA-binding domain, to target sites containing the GAGAG consensus motif. Binding is suppressed, as in the GAGA factor and other proteins of the family, by the associated protein-protein interaction motif. The DNA-binding domain, which we call the Psq domain, is identical with a previously identified region consisting of four tandem repeats of a conserved 50-amino acid sequence, the Psq motif. The Psq domain seems to be structurally related to known DNA-binding domains, both in its repetitive character and in the putative three-α-helix structure of the Psq motif, but it lacks the conserved sequence signatures of the classical eukaryotic DNA-binding motifs. Psq may thus represent the prototype of a new family of DNA-binding proteins.
Functional Results After External Vocal Fold Medialization Thyroplasty With the Titanium Vocal Fold Medialization Implant

Objectives/Hypothesis A persistent insufficiency of glottal closure is mostly a consequence of a unilateral vocal fold movement impairment. It can also be caused by vocal fold atrophy or scarring processes with regular bilateral respiratory vocal fold function. Because of consequential voice, breathing, and swallowing impairments, a functional surgical treatment is required. The goal of the study was to outline the functional results after medialization thyroplasty with the titanium vocal fold medialization implant according to Friedrich.
A surface on the androgen receptor that allosterically regulates coactivator binding

Current approaches to inhibit nuclear receptor (NR) activity target the hormone binding pocket but face limitations. We have proposed that inhibitors, which bind to nuclear receptor surfaces that mediate assembly of the receptor's binding partners, might overcome some of these limitations. The androgen receptor (AR) plays a central role in prostate cancer, but conventional inhibitors lose effectiveness as cancer treatments because anti-androgen resistance usually develops. We conducted functional and x-ray screens to identify compounds that bind the AR surface and block binding of coactivators for AR activation function 2 (AF-2). Four compounds that block coactivator binding in solution with IC50 ≈ 50 μM and inhibit AF-2 activity in cells were detected: three nonsteroidal antiinflammatory drugs and the thyroid hormone 3,3′,5-triiodothyroacetic acid. Although visualization of compounds at the AR surface reveals weak binding at AF-2, the most potent inhibitors bind preferentially to a previously unknown regulatory surface cleft termed binding function (BF)-3, which is a known target for mutations in prostate cancer and androgen insensitivity syndrome. X-ray structural analysis reveals that 3,3′,5-triiodothyroacetic acid binding to BF-3 remodels the adjacent interaction site AF-2 to weaken coactivator binding. Mutation of residues that form BF-3 inhibits AR function and AR AF-2 activity. We propose that BF-3 is a previously unrecognized allosteric regulatory site needed for AR activity in vivo and a possible pharmaceutical target.
International Conference on Intelligent Robots and Systems Mobile Manipulation of Humanoid Robots-Analysis of Manipulability and Stability in Mobile Manipulation

This paper describes mobile manipulation of humanoid robots. A humanoid robot is a kind of integrated machines: two a r m and two leg mechanism. It could be well applied to mobile manipulation in nonroutine task automation. The main objective of the mobile manipulation is t o obtain versatile and eficient manipulation b y the arms. In this respect the legs are required to assist the arms obtaining their high manipulability b y changing step length and timing of step motion. Accordingly, the required motion of the legs in mobile manipulation is different from conventional biped locomotion. From this point of view, the relationship between manipulability of the a r m and various leg motions is analyzed and evaluated by computer simulations.
[Diagnosis and treatment of cardiopulmonary hantavirus syndrome: Chile-2007].

En un mundo globalizado como el de hoy, se han ampliado los mecanismos de participación ciudadana y fortalecido las organizaciones sociales. Ello ha traído consigo ciudadanos más informados y, por consiguiente, la necesidad de contar con profesionales de la medicina capaces de responder a esa demanda. Esperamos que esta guía sea una herramienta facilitadora que contribuya al trabajo de los equipos clínicos de nuestro sistema sanitario y a la mejoría de la calidad asistencial.
SELDOM-ENCOUNTERED AGENTS OF BACTERIAL MENINGITIS.

In five cases of bacterial meningitis (one associated with a brain abscess) four seldom-encountered bacteria were identified as causative agents: Mima polymorpha, Listeria monocytogenes, Corynebacterium acnes , and Serratia marcescens . Circumspection is required of the bacteriologist and physician concerning "contaminants" introduced nosocomially or iatrogenically. Various methods for culture of certain recalcitrant "problem bacteria" are suggested.
Dual-Function Gate Driver for a Power Module With SiC Junction Field-Effect Transistors

Silicon Carbide high-power modules populated with several parallel-connected junction field-effect transistors must be driven properly. Parasitic elements could act as drawbacks in order to achieve fast and oscillation-free switching performance, which are the main goals. These two requirements are related closely to the design of the gate-drive unit, and they must be kept under certain limits when high efficiencies are targeted. This paper deeply investigates several versions of gate-drive units and proposes a dual-function gate-drive unit which is able to switch the module with an acceptable speed without letting the current suffer from significant oscillations. It is experimentally shown that turn-on and turn-off switching times of approximately 130 and 185 ns respectively can be reached, while the magnitude of the current oscillations is kept at an adequate level. Moreover, using the proposed gate driver an efficiency of approximately 99.7% is expected for a three-phase converter rated at 125 kVA and having a switching frequency of 2 kHz.
Enhanced Anonymization and Clustering of OSN

In current scenario online social networks such as Facebook, LinkedIn are increasingly utilized by many people. These platforms have successfully created a virtual world by allowing the user to connect with each other just by sharing information about themselves. The information disclosed in here are public as well as private which has created a lot of trouble in recent times. The More data is shared by people the more privacy issues are being violated. In shared data publishing process, we need not only protect the privacy of data but also insure the data‟s integration. To address this issue we proposed the solution of reliable and secure data set by using various Anonymization and clustering concepts and then this paper explores data randomization, i.e. our method maintains statistical relations among data to preserve knowledge, whereas in most anonymization methods, knowledge is lost then we shift on how to launch inference attacks using released social networking data to predict private information and then our work shows the effectiveness of these techniques and finally we worked on how we can decrease the privacy leakage from social networks.
BRAIN EDEMA, ELECTROLYTES, AND EXTRACELLULAR SPACE. EFFECT OF TRIETHYL TIN OR BRAIN AND SKELETAL MUSCLE.

During the course of a number of studies of the blood-brain barrier, the urgent need for good physiological measurements of the size of the functional compartments (extracellular space, glial space, neuronal space, etc) of the central nervous system became apparent. In one of these studies the volume of distribution of sucrose in the CNS was investigated. It was observed that sucrose distributed in two compartments of the brain at markedly different rates. On this basis it was suggested that the compartment with the shortest half-time for sucrose entry was the extracellular space and that the other compartment was the intracellular, composed of one or more cell types, possibly glial cells.14 Triethyl tin (TET) in very small quantities causes cerebral edema, shown by Torack et al19to be confined to the glial cells although other workers have suggested that TET edema is extracellular.11Luse and Harris10have
Cost-effectiveness analysis of treatment of methicillin-resistant Staphylococcus aureus bacteremia and endocarditis is a difficult issue.

Methicillin-resistant Staphylococcus aureus (MRSA) was first detected in 1961. Today, MRSA is widely spread around the world. In the United States [1] and in many European countries, 25%–50% of S. aureus isolates are MRSA [2], even if some countries (eg, the Netherlands and the Scandinavian countries) have a low level of cases of invasive MRSA infection. Invasive MRSA infections, such as bacteremia and endocarditis, are difficult to treat because the treatment options are limited. MRSA bacteremia also has a higher mortality rate than does bacteremia due to methicillin-susceptible S. aureus (MSSA) [3]. Infective endocarditis due to MRSA has a trend toward a higher mortality rate compared with that due to MSSA [4]. Many of the patients are immunocompromised with underlying diseases and may have intracardiac devices or intravenous catheters in place, and such infections are difficult to treat without replacement of these devices.
Extremely low frequency magnetic fields and the promotion of H2O2‐induced cell death in HL‐60 cells

Purpose: To test whether exposure to an extremely low frequency magnetic field (60 Hz, 5 mT) affects hydrogen peroxide (H2O2)‐induced cell death in human leukaemia HL‐60 cells. Materials and methods: Cells were treated with H2O2 with or without exposure to an extremely low frequency magnetic fields. Viable cells, apoptotic and necrotic cells were determined by annexin V flow cytometry assay. The levels of apoptosis‐related proteins (caspase‐3, caspase‐7, Bcl‐2 and Bax) and poly(ADP‐ribose) polymerase were detected using Western blotting. Results: Simultaneous treatment with exposure to the magnetic field and H2O2 (85 or 100 µM) for 24 h increased the number of apoptotic and necrotic cells significantly, and significantly decreased the number of viable cells compared with cells treated with H2O2 alone. The protein levels of Bax and Bcl‐2 showed no differences between H2O2‐treated cells and those treated with both H2O2 and an extremely low frequency magnetic field. Exposure to the magnetic field also had no effect on H2O2‐induced caspase‐3 activation. However, the protein levels of active caspase‐7 in cells simultaneously exposed to an extremely low frequency magnetic field and H2O2 for 2 and 8 h was higher than that of H2O2 treatment alone. In addition, simultaneous exposure to an extremely low frequency magnetic field and H2O2 caused poly(ADP‐ribose) polymerase cleavage and induced early inactivation at 2 h, while H2O2 treatment alone did not produce this effect until 4 h. Conclusions: The data suggest that although the magnetic field itself cannot induce apoptosis and necrosis, it exerts a promoting effect on H2O2‐induced cell death, and it demonstrates that caspase‐7 as well as poly(ADP‐ribose) polymerase might be involved in this process.
Coping strategies in mothers and fathers of preschool and school-age children with autism

Despite the theoretical and demonstrated empirical significance of parental coping strategies for the wellbeing of families of children with disabilities, relatively little research has focused explicitly on coping in mothers and fathers of children with autism. In the present study, 89 parents of preschool children and 46 parents of school-age children completed a measure of the strategies they used to cope with the stresses of raising their child with autism. Factor analysis revealed four reliable coping dimensions: active avoidance coping, problem-focused coping, positive coping, and religious/denial coping. Further data analysis suggested gender differences on the first two of these dimensions but no reliable evidence that parental coping varied with the age of the child with autism. Associations were also found between coping strategies and parental stress and mental health. Practical implications are considered including reducing reliance on avoidance coping and increasing the use of positive coping strategies.
Role of turmeric in oxidative modulation in end‐stage renal disease patients

Oxidative stress is considered as a major player in uremia‐associated morbidity and mortality in hemodialysis (HD) patients. The aim of this study was to evaluate the effects of turmeric on oxidative stress markers in HD patients. This study was a prospective and double‐blind randomized clinical trial. Fifty HD patients aged 18–60 years were recruited after fulfilling the inclusion criteria. Patients were randomly categorized into 2 groups: trial group received turmeric and control group received placebo for 8 weeks. Each patient in the trial group received turmeric, whereas the control group received starch for the same 8 weeks. Plasma malondialdehyde (MDA), red blood cell (RBC) antioxidant enzyme activities as glutathione peroxidase (GPX), glutathione reductase (GR), and catalase (CAT), cholesterol, high‐density lipoprotein‐cholesterol, low‐density lipoprotein‐cholesterol, triglyceride, albumin, and hemoglobin were also measured before and after study. Although MDA level was reduced in both groups, the ratio of decrease was significantly higher in the turmeric group (0.2 vs. 0.1, P = 0.040). Three enzymes of GPX, GR, and CAT levels were increased in both groups; the ratio of increased was significantly higher in the turmeric group for the CAT enzyme (0.73 vs. 0.54; P = 0.02). Also, significant elevation of albumin level in the turmeric group compared with the control group was observed (P = 0.001). Regular ingestion of turmeric reduces plasma MDA and increases RBC CAT activity and plasma albumin levels in HD patients. Turmeric showed no adverse effects.
Off-line constant current LEDs driver using the HVLED primary controller

The article introduces an off-line constant current LEDs driver controller, using the HVLED, an innovative all-primary controller, by STMicroelectronics. Using the proprietary patented technique, the IC is able of providing a constant output current using primary sensing feedback, thus eliminating the need for the optocoupler, secondary voltage reference and current sensor, still maintaining quite accurate current regulation. The power supply is able to drive up to 4 LEDs in the European range, i.e. 185–265VAC, even if the same configuration can be also used in U.S. range and for a different numbers of LEDs, only limited from the maximum IC power capability. The proposed driver can be suitably used in all the applications where the tight regulation tolerance, efficiency performances and low component count are decisive to meet the LED's market requirements.
Angiotensin Converting Enzyme Inhibitors Enhance the Antihypertensive Efficacy of Diuretics and Blunt or Prevent Adverse Metabolic Effects

Angiotensin converting enzyme (ACE) inhibition has provided a new approach to the treatment of hypertension. The broad efficacy of ACE inhibitors across the entire spectrum of hypertension exceeds original predictions. Diuretics have been shown to extend efficacy to over 85% of noncomplicated hypertensives. In addition to efficacy, combination of ACE inhibitors with diuretics permits prevention or attenuation of many undesirable side effects of diuretic therapy, including hypokalemia, hyperuricemia, hyperglycemia, and hypercholesterolemia. Thus, considerations of both efficacy and beneficial effects on cardiovascular disease risk factors make the combination of ACE inhibitors and diuretics an attractive one in the treatment of hypertension.
Research on optimizing control of high-power dual-inverter drive system

The superiority of Selective Harmonics Elimination Pulse Width Modulation (SHEPWM) control technique for dual inverter drive system is mainly studied. The SHEPWM mathematical model is established and its solving method is given. By analyzing the harmonic components of DC side capacitor in dual inverter, an optimizing control strategy based on SHEPWM is put forward for the structure of dual inverter drive system. Finally a computer simulation with obtained switching angles is made. The capacity current waveforms before and after optimizing control was compared, as well as the DC side harmonics while in the case of asymmetric load and symmetric load between two inverters. By analysis, the optimization strategy is verified and the optimizing goal by eliminating the harmonics below 103th in the output voltage is achieved.