Miracle-dz/UniFAR-FTUs huggingface dataset:
Biomechanical and Histological Evaluations of the Doubled Semitendinosus Tendon Autograft After Anterior Cruciate Ligament Reconstruction in Sheep

Background: A sheep or goat anterior cruciate ligament (ACL) reconstruction model with the semitendinosus tendon autograft has not as of yet been established. Hypothesis: The semitendinosus tendon graft may be necrotized after ACL reconstruction until 12 weeks. Structural properties of the femur-graft-tibia complex may not be restored to the normal ACL level even at 12 months after surgery. Study Design: Controlled laboratory study. Methods: Thirty-eight mature sheep were used. In each animal, the right knee underwent ACL reconstruction using the semitendinosus tendon autograft. Two of them were not tested because of pneumonia. Twenty of 36 sheep were used for biomechanical evaluations. Five randomly selected animals were sacrificed at 0, 12, 24, or 52 weeks after surgery. In each animal, both the knees were harvested, and the left knee was used to obtain the control data. The remaining 16 sheep were used for histological evaluation. Two or 3 randomly selected animals were sacrificed at 0, 2, 6, 12, 24, or 52 weeks after surgery. Results: The tendon graft was predominantly acellular at 2 weeks. Although cell infiltration increased at 6 weeks, the core portion remained necrotic even at 12 weeks. At 24 and 52 weeks, the necrotic lesion disappeared in the core portion. In each period, the anteroposterior translation of the reconstructed knee remained significantly greater than that of the control (P < .0001). At 52 weeks, the maximum load of the femur-graft-tibia complex was significantly lower than that of the femur-ACL-tibia complex (P < .0001), although there was no significant difference in the cell density, the tissue dimensions, the stiffness, and the elongation at failure between the 2 complexes. Conclusion: The sheep ACL reconstruction model showed predominant intrinsic fibroblast necrosis in the tendon autograft until 12 weeks. Although the structural properties of the femur-graft-tibia complex gradually improved, they were not completely restored to the femur-ACL-tibia complex level even at 52 weeks. Clinical Relevance: Remodeling of the semitendinosus tendon autograft after ACL reconstruction is not different from that of the bone-tendon-bone graft. This study has suggested that vigorous activity should not be permitted for patients in the early periods after ACL reconstruction using semitendinosus tendon autografts, which are necrotized and weakened after surgery.
Crossing studies in cyphomandra solanaceae and their systematic and evolutionary significance

A crossing program involving eight species of Cyphomandra was instituted to elucidate systematic relationships between the taxa and evolutionary mechanisms operating in the genus. The results show that gametophytic self-incompatibility is widespread in Cyphomandra. Pollen tubes were able to reach the ovules in nearly all interspecific crosses. Most of these crosses failed, however, indicating that postzygotic barriers are important in reproductive isolation. Only five of 44 interspecific combinations attempted have produced viable seeds. F, plants have been evaluated from three of the five hybrid combinations: C. betacea x acuminata, C. uniloba x betacea, and C. corymbiflora x diploconos. All three hybrid combinations show reduced fertility as compared to the parents, apparently caused in part by differences in chromosome structure between parent species. Crossing success was congruent with morphological similarity in C. betacea, C. acuminata, and C. uniloba, but not in C. corymbiflora and C.
Análisis de la aplicación de la realidad aumentada en el sector turístico: una propuesta de mejora

El presente trabajo tiene como objetivo realizar un estudio sobre las nuevas tecnologias aplicadas al turismo, centrandose en la utilizacion de una nueva herramienta tecnologica movil de gran potencial para el sector, la realidad aumentada (RA). Para alcanzar dicho objetivo se ha realizado un estudio sobre su impacto, considerando todas sus aplicaciones, en el ambito del turismo. Tras el estudio llevado a cabo, se ha concluido que la RA cubre ciertas necesidades que el turista pueda tener y, ademas, enriquece su vivencia en la practica turistica. Sin embargo, se ha detectado una necesidad de mejora de la RA, asi como de una mayor promocion por parte de los destinos turisticos, debido a que aun impera cierto desconocimiento por parte de los destinatarios finales de estas herramientas tecnologicas.
Endocrine therapy initiation from 2001 to 2008 varies by age at breast cancer diagnosis and tumor size.

PURPOSE To evaluate tamoxifen and aromatase inhibitor (AI) initiation over time and by patient characteristics among women diagnosed with breast cancer in a community setting. METHODS We conducted a retrospective cohort study of 1,501 women age ≥ 18 years diagnosed with stages I to II invasive, hormone receptor-positive breast cancer from 2001 to 2008 in an integrated delivery system. Using automated pharmacy dispensings, we determined endocrine therapy receipt within 12 months of diagnosis. We used generalized linear models to estimate adjusted relative risks (RRs) with 95% CIs for any endocrine therapy use (v none), tamoxifen use (v none), AI use (v none), and AIs first (v tamoxifen). Each model adjusted for age, stage, body mass index, tumor size, lymph node status, comorbidities, other treatment, and diagnosis year. RESULTS Tamoxifen use was at its highest (56.9%) in 2001 and then decreased; AI use was lowest in 2001 (5.5%) and then peaked in 2005 (36.8%). In multivariate models, women age ≥ 65 years were less likely to use any endocrine therapy compared with women age 55 to 64 years (age 65 to 74 years: RR, 0.86; 95% CI, 0.78 to 0.96; age ≥ 75 years: RR, 0.71; 95% CI, 0.61 to 0.81). Women age ≥ 75 years were significantly less likely to begin AIs versus no treatment (RR, 0.46; 95% CI, 0.32 to 0.64) and versus tamoxifen (RR, 0.67; 95% CI, 0.46 to 0.97). Women with tumor sizes 1.0 to 1.9 cm and ≥ 2.0 cm were significantly more likely to use any endocrine therapy compared with women with tumor sizes < 1.0 cm (RR, 1.41; 95% CI, 1.23 to 1.61 and RR, 1.52; 95% CI, 1.27 to 2.81, respectively). CONCLUSION Differential initiation over time, as well as by age and tumor size, suggests patient preferences and provider recommendations for endocrine therapy vary, despite guideline recommendations.
Emotion communication and language socialisation

In this paper, we provide some background to our research project on the study of self-disclosure and negative emotion communication among three cultural groups, drawing on data collected in Anglo-Australian, French and Italian films. Our project involved the elaboration of a model of the cultural script of anger display in interactions involving male friends, and the observation and analysis of non-verbal responses based on a small corpus. Results of this study support the view that although there are common sets of nonverbal features associated to listeners’ responses, there are also cultural optional variants. For example, the provision of a backchannel cue (vocalization, head nod or shake) appears to be common to all groups to signal the “entering” strategy, whereas smiling or touching are optional variants as they may be considered culturally inappropriate. This study contributes to the constitution of social knowledge on emotion and adds to a growing body of data regarding the non-verbal expression of emotion within a cross-cultural perspective which can be of benefit to L2 learners and teachers.
Patient-reported outcome results from the open-label phase III AURELIA trial evaluating bevacizumab-containing therapy for platinum-resistant ovarian cancer.

PURPOSE To determine the effects of bevacizumab on patient-reported outcomes (PROs; secondary end point) in the AURELIA trial. PATIENTS AND METHODS Patients with platinum-resistant ovarian cancer were randomly assigned to chemotherapy alone (CT) or with bevacizumab (BEV-CT). PROs were assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Ovarian Cancer Module 28 (EORTC QLQ-OV28) and Functional Assessment of Cancer Therapy-Ovarian Cancer symptom index (FOSI) at baseline and every two or three cycles (8/9 weeks) until disease progression. The primary PRO hypothesis was that more patients receiving BEV-CT than CT would achieve at least a 15% (≥ 15-point) absolute improvement on the QLQ-OV28 abdominal/GI symptom subscale (items 31-36) at week 8/9. Patients with missing week 8/9 questionnaires were included as unimproved. Questionnaires from all assessments until disease progression were analyzed using mixed-model repeated-measures (MMRM) analysis. Sensitivity analyses were used to determine the effects of differing assumptions and methods for missing data. RESULTS Baseline questionnaires were available from 89% of 361 randomly assigned patients. More BEV-CT than CT patients achieved a ≥ 15% improvement in abdominal/GI symptoms at week 8/9 (primary PRO end point, 21.9% v 9.3%; difference, 12.7%; 95% CI, 4.4 to 20.9; P = .002). MMRM analysis covering all time points also favored BEV-CT (difference, 6.4 points; 95% CI, 1.3 to 11.6; P = .015). More BEV-CT than CT patients achieved ≥ 15% improvement in FOSI at week 8/9 (12.2% v 3.1%; difference, 9.0%; 95% CI, 2.9% to 15.2%; P = .003). Sensitivity analyses gave similar results and conclusions. CONCLUSION Bevacizumab increased the proportion of patients achieving a 15% improvement in patient-reported abdominal/GI symptoms during chemotherapy for platinum-resistant ovarian cancer.
The Effect of Inbreeding and Crossbreeding Upon Development.

The experiments dealing with the effects of inbreeding and crossbreeding in the naturally cross-pollinated corn plant, Zea mays L. , carried on at the Connecticut Experiment Station have been reported on previously by East2 and Hayes.3 A continuation of these experiments shows that tlere is no appreciable reduction in vigor and productiveness, as indicated by the yield of grain and height of plant, after the eighth generation of self-fertilization as can be seen in table 1. The resulting inbred strains, now in the eleventh
Finger-Pressure Waveforms Measured on Clynes' Sentograph Distinguish among Emotions

We examined the transient finger-pressure when subjects were exposed to the schematic faces which depict “anger,” “joy,” “sadness,” and “no emotion,” and to two nonfacial stimuli. In Exp. 1, nine undergraduate women were asked to discriminate between those target stimuli and the nontarget stimuli by pressing on the finger rest of Clynes' Sentograph, without informing subjects that this experiment was to measure emotions. In Exp. 2, the same subjects were asked to express their feelings evoked by the schematic faces by pressing on the finger rest. Results indicate that, even on the discrimination task, the differentiation in the finger-pressure waveforms among emotions was observed. Such differentiation suggests the possibility of measuring the expression of emotions with finger pressure even when the subjects are not aware their emotions are being measured. The identifiable characteristics of the waveforms are the long duration for “sadness” and the strong intensity of pressure for “anger. ”
A New View of Hybridized Atomic Orbitals from N-dimensional World

By taking a birds-eye view from the n-dimensional world (or n-space), it was found that the conventionally used sp, sp 2 , and sp 3 hybridized atomic orbitals belong to the sp n hybridization and their geometrical shapes correspond to n-simplexes, which are, respectively, the smallest geometrical objects in n-space. Similarly, sp, sp 2 d, and sp 2 d 3 hybridizations are found to belong to the sp n d n–1 hybridization, whose geometrical shapes correspond to n-cross polytopes (obtained from 2n vertices equidistantly located on n rectangular coordinate axes). Another series of n-cube hybridization is also discussed, whose 3-space member is 8-coordinated cubic hybridization, sp 3 d 3 f. General analytical forms of the wavefunctions of these three series of hybridized atomic orbitals in n-space are obtained. The periodic table and related problems of atoms and molecules in n-space are discussed.
Zero dispersion in attenuation optimized doubly clad fibers

In a weakly guiding single-mode fiber, there exists an optimum value for the HE11mode spot size, which minimizes splicing and microbending losses. Zero dispersion and this optimum spot size for the mode can simultaneously be achieved with any inner-cladding depth; increasing the inner-cladding depth, however, allows smaller dopant concentrations in the core and thus lower intrinsic losses, but this induces an enhanced sensitivity to curvatures and to parameter fluctuations. When the inner-cladding depth is sufficiently high, on the other hand, the fundamental mode has a nonzero cutoff and dispersion can be minimized over a wide spectral range. At\lambda = 1.55\mum, we determine the optimum value for the inner-cladding depth from criteria of both sensitivity to bending and fabrication tolerances or by requiring a given mode dispersion behavior over a wide spectral range.
×Phosphorylation of Bax Ser184 by Akt Regulates Its Activity and Apoptosis in Neutrophils*

Although important for apoptosis, the mechanism of Bax regulation is poorly understood. This study demonstrates that phosphorylation of Ser184 regulates Bax activity. The phosphorylation required phosphatidylinositol 3-kinase/Akt activation and appeared to be mediated by Akt itself. In the serine-phosphorylated form, Bax was detected in the cytoplasm, could not be immunoprecipitated with the activation-specific antibody 6A7, and promoted heterodimerization with Mcl-1, Bcl-xL, and A1. Apoptotic neutrophils possessed reduced levels of serine-phosphorylated Bax correlating with an increase in activated Bax as well as an increase in the amount of Bax found translocated to the mitochondria. We suggest that Bax is regulated by phosphorylation of Ser184 in an Akt-dependent manner and that phosphorylation inhibits Bax effects on the mitochondria by maintaining the protein in the cytoplasm, heterodimerized with antiapoptotic Bcl-2 family members.
[Occupational rhinitis].

INTRODUCTION Rhinitis is one of the most common occupational diseases. It is often neglected by those affected because it causes little disability. It is poorly understood by doctors who have insufficient experience of occupational diseases and their causes. However it is often the first manifestation of a respiratory disorder that may cause physical complications and socio-economic disability. BACKGROUND Numerous diverse agents are potential causes of rhinitis. The diagnosis of occupational rhinitis should be considered when sneezing, rhinorrhoea or nasal obstruction are associated with work. The causal agent can be identified by ta-king a careful history. When the mechanism of the disease is immunologic the suspected antigen can be confirmed by skin testing, specific IgE or nasal provocation. The respiratory disorder of which rhinitis is the first manifestation may progress to asthma if the exposure continues. The prevention of occupational rhinitis depends on the reduction of exposure to allergens and/or irritants. When it has developed removal of the causative agent is essential to prevent progression to asthma.
From partial derivatives of 3-D density images to ridge lines

Three-dimensional edge detection in voxel images is used to locate points corresponding to surfaces of 3-D structures, and the local geometry of these surfaces is characterized in order to extract points or lines which may be used by registration and tracking procedures. Typically, second-order differential characteristics of the surfaces must be calculated. To avoid the problem of establishing links between 3-D edge detection and local surface approximation it is proposed to compute the curvatures at locations designated as edge points, using the partial derivatives of the image directly. By assuming that the surface is defined locally by an iso-intensity-contour, it is possible to calculate directly the curvatures and characterize the local curvature extrema (ridge points) from the first, second, and third derivatives of the gray-level function. These partial derivatives can be computed using the operators of the edge detection. Experimental results obtained using real X-ray scanner data are presented. <<ETX>>
Reduced short-term memory capacity in Alzheimer's disease: The role of phonological, lexical, and semantic processing

Individuals with Alzheimer's disease (AD) are often reported to have reduced verbal short-term memory capacity, typically attributed to their attention/executive deficits. However, these individuals also tend to show progressive impairment of semantic, lexical, and phonological processing which may underlie their low short-term memory capacity. The goals of this study were to assess the contribution of each level of representation (phonological, lexical, and semantic) to immediate serial recall performance in 18 individuals with AD, and to examine how these linguistic effects on short-term memory were modulated by their reduced capacity to manipulate information in short-term memory associated with executive dysfunction. Results showed that individuals with AD had difficulty recalling items that relied on phonological representations, which led to increased lexicality effects relative to the control group. This finding suggests that patients have a greater reliance on lexical/semantic information than controls, possibly to make up for deficits in retention and processing of phonological material. This lexical/semantic effect was not found to be significantly correlated with patients’ capacity to manipulate verbal material in short-term memory, indicating that language processing and executive deficits may independently contribute to reducing verbal short-term memory capacity in AD.
A Cultural Analysis of the difference between Interpersonal Trust and Institutional Trust

The developing world’s electronic commerce potential is huge. However, it has been demonstrated that successful e-business models from developed countries do not seem to transfer well to developing countries. We argue one reason for this is that perceptions of trust differ across developing and developed nations. This, in turn, requires a different design for e-commerce markets. This paper focuses on the impact of trust perception on infrastructure in Chinese e-commerce. A price comparison of Taobao (an institutional trust-based electronic market) and WeChat (an interpersonal trust-based electronic market) for 34 products purchased from outside China demonstrates that sellers in interpersonal trust-based electronic markets can command a higher price than those in institutional trust-based ones. Furthermore, trust labels (a standard form of institutional trust in western e-markets) appear to command no benefit in China. Our research suggests e-commerce companies planning on moving to China should focus on incorporating technologies facilitating interpersonal trust rather than institutional trust.
Inhibition of advanced glycation end-product formation on eye lens protein by rutin

Formation of advanced glycation end products (AGE) plays a key role in the several pathophysiologies associated with ageing and diabetes, such as arthritis, atherosclerosis, chronic renal insufficiency, Alzheimer's disease, nephropathy, neuropathy and cataract. This raises the possibility of inhibition of AGE formation as one of the approaches to prevent or arrest the progression of diabetic complications. Previously, we have reported that some common dietary sources such as fruits, vegetables, herbs and spices have the potential to inhibit AGE formation. Flavonoids are abundantly found in fruits, vegetables, herbs and spices, and rutin is one of the commonly found dietary flavonols. In the present study, we have demonstrated the antiglycating potential and mechanism of action of rutin using goat eye lens proteins as model proteins. Under in vitro conditions, rutin inhibited glycation as assessed by SDS-PAGE, AGE-fluorescence, boronate affinity chromatography and immunodetection of specific AGE. Further, we provided insight into the mechanism of inhibition of protein glycation that rutin not only scavenges free-radicals directly but also chelates the metal ions by forming complexes with them and thereby partly inhibiting post-Amadori formation. These findings indicate the potential of rutin to prevent and/or inhibit protein glycation and the prospects for controlling AGE-mediated diabetic pathological conditions in vivo.
Role of service characteristics in determining the degree of customer involvement: a typology

Involving customers in the generation of services is important for service firms because such involvement can help firms develop their competitive quality. Services differ in their fundamental attributes; therefore, any attempt to classify services based on the degree of customer involvement must consider their attributes. No comprehensive framework is available in the extant literature to guide firms to evaluate their service offerings from a customer involvement perspective. Applying the customer contact model and the customer involvement perspective, this manuscript attempts to offer a three-dimensional typology that can be used by service firms to determine the degree of customer involvement in service generation. The three dimensions of the typology are obtained by combining the appropriate attributes from a list of nine common service characteristics. By involving the customers to a greater degree when predicted, service firms can substitute their own employee effort with customers’ effort to some degree.
care costs in China household expenditure patterns and medical The impact of smoking and quitting on

These include: Material Supplemental html http://tobaccocontrol.bmj. com/content/suppl/2009/03/24/tc.2008. 026955.DC1. References http://tobaccocontrol.bmj. com/content/18/2/150.full. html#ref-list-1 This article cites 19 articles, 9 of which can be accessed free at: Open Access is properly cited. use, distribution, and reproduction in any medium, provided the original work Commons Attribution Non-commercial License, which permits unrestricted This is an open-access article distributed under the terms of the Creative