Miracle-dz/UniFAR-FTUs huggingface dataset:
The Risks of Living Kidney Donation.

Only candidates with an apparent low risk of kidney disease are accepted as living kidney donors. Postdonation studies that extend up to 12 years have shown rates of end-stage renal disease (ESRD) among donors that are similar to those observed in the general population, which suggests minimal risk from the inevitable reduction in the glomerular filtration rate (GFR) that occurs at donor nephrectomy.1 However, a recent 7.6-year study in the United States showed that the incidence of ESRD was 8 times as high among donors as among well-selected nondonor controls.2 A similar 15.2-year study in Norway showed that the risk .
QTc Prolongation in Acute Methadone Poisoning

Background : Methadone is considered as a good choice for maintenance treatment program (MMTP) in opioid addicted individuals. QT interval prolongation was reported previously in methadone chronic usersespecially in high dose prescription. QT-interval prolongation predisposes patients to lethal dysrhythmia. This is a report of corrected QT(QTc) prolongation due to acute methadone poisoning. To the best of our knowledge, in review of literatures, there is no previous report of QTc prolongation in cases that are not on chronic methadone therapy. Case Report: The patient was a 20 years old man who has occasionally used opium and ice since 8 month before admission. One night before admission he consumed ice and found psychotic state so he was referred to the addiction treatment center and they put him on methadone maintenance treatment with high dose of methadone. After 40 minutes the patient was drowsy and then hypopnea was started. The patient was referred to the hospital and resuscitation was done after naloxone prescription. After stabilizing general conditions the electrocardiograph shows QTc prolongation which was returned to normal status after 2 days. After 5 days the patient was transferred to psychiatric service with normal sinus rhythm and stable condition. Conclusion: QT interval prolongation in chronic methadone maintenance therapy is defined previously especially in patients on other drugs that interact with the CYP3A4 isoenzyme system and who are on high dose methadone treatment, but it seems that acute methadone intoxication also may prolong the QT interval which should be investigated in future studies.
Endarterectomy, Stenting, or Neither for Asymptomatic Carotid-Artery Stenosis.

Important data from two large, randomized trials comparing early and late outcomes after carotid endarterectomy and carotid-artery stenting have now been published in the Journal.1,2 In common with every other large, multicenter, randomized trial to date, the Asymptomatic Carotid Trial (ACT I) and the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) showed that after the perioperative period, there was no difference in the rate of late ipsilateral stroke after endarterectomy or stenting. In ACT I, which included asymptomatic patients who were deemed to be at average risk, the 5-year rate of ipsilateral stroke (excluding the perioperative period) was .
Cardiac and Renovascular Complications in Type 2 Diabetes--Is There Hope?

According to the current posting on the website of the World Health Organization, the worldwide prevalence of diabetes mellitus among persons 18 years of age or older is 8.5% and increasing. Most of those affected have type 2 diabetes, which has been epidemic for several decades and is associated with many complications, including premature macrovascular and microvascular diseases affecting the eyes, heart, kidneys, and the circulation. We know that diabetes is associated with major morbidity and mortality, with an estimated 1.5 million deaths in 2012 being directly due to diabetes.1 Various approaches in the treatment of type 2 diabetes have .
Activities and mortality in the elderly: the Leisure World cohort study.

BACKGROUND Although physical activity has substantial health benefits and reduces mortality, few studies have examined its impact on survival beyond age 75. METHODS Using the population-based Leisure World Cohort Study, we explored the association of activity on all-cause mortality in older adults (median age at baseline = 74 years). We followed 8,371 women and 4,828 men for 28 years or until death (median = 13 years) and calculated relative risks for various measures of activity at baseline using Cox regression analysis for four age groups (<70, 70-74, 75-79, and 80+ years) in men and women separately. RESULTS Time spent in active activities, even ½ hour/day, resulted in significantly lower (15-35%) mortality risks compared with no time in active activities. This reduction was evident in all sex-age groups except the youngest men. Participants who reported spending 6 or more hours/day in other less physically demanding activities also had significantly reduced risks of death of 15-30%. The beneficial effect of activities was observed in both those who did and those who did not cut down their activities due to illness or injury. Neither adjustment for potential confounders, exclusion of the first 5 years of follow-up, nor exclusion of individuals with histories of chronic disease substantially changed the findings. CONCLUSIONS Participation in leisure-time activities is an important health promoter in aging populations. The association of less physically demanding activities as well as traditional physical activities involving moderate exertion with reduced mortality suggests that the protective effect of engagement in activities is a robust one.
Magnitude of Mental Illness and Associated Factors among Holy Water Users at Entoto St. Mary Church, Addis Ababa, Ethiopia, 2014

Introduction: Mental disorders are among the major causes of impairment which results in serious economical, social and other consequences. Many people with this disorder get religious help before or after getting modern treatment. Despite this there is lack of information which indicates the magnitude of mental illness among holy water users and associated factors. Objective: The aim of the study was to assess the prevalence and associated factors of mental illness among holy water users at Entoto St. Mary Church, Addis Ababa, Ethiopia, 2014. Method: Cross sectional study design was conducted from April 28-May 28, 2014 at Entoto St. Mary church. A total of 416 holy water users were included in the study. The participants were selected using systematic random sampling method. Data were collected by face-to-face interviews using structured questionnaire for socio demographic factors, substance related factors using WHO’s ASSIST, interview and observation by Brief Psychiatric Rating Scale (BPRS) for mental illness symptoms and clinical factors were collected using structured questionnaires. Result: A total of 416 participants were interviewed and observed with a response rate of 98.35%. The prevalence of mental illness was 60.1% with 95% CI, (54.34, 65.86). Being jobless [AOR=2.42, 95% CI (1.37,4.28)], ever use of more than one substance (i.e. alcohol, tobacco, khat and cannabis) [AOR=2.4, 95% CI (1.39, 4.17)], current daily drinking of alcohol [AOR=5.08, 95% CI (2.08, 12.2)], having previous history of mental illness [AOR=5.82, 95% CI (2.732,12.378)] and having a known medical or surgical problem [AOR=2.46, 95% CI (1.39,4.34)] were significantly associated with mental illness. Conclusion: More than half of holy water users had mental illness so it needs to give attention to develop reference link between psychiatric institutions and religious places, people’s awareness about the cause, consequence and treatment options of mental illness must be enhanced.
Which Anti-CD20 Antibody Is Better in Follicular Lymphoma?

Rituximab changed the treatment of patients with follicular lymphoma. When added to standard chemotherapy regimens, it increased the response rate and the complete remission rate.1,2 Rituximab has often been administered as maintenance therapy after a remission that was induced either by single-agent rituximab or by rituximab combined with standard chemotherapy drugs, and it has been shown to prolong the duration of remission.3,4 Since 2000, when rituximab became widely available, survival among patients with low-grade follicular lymphoma has increased from a median of approximately 10 years to a median of approximately 15 to 20 years.5,6 In this issue of the Journal, .
Diagnostic Value of Barium Esophagogram and Bernstein Test in Patients with Esophagitis

From the 19th of July to the 19th of October 1999, we conducted a study to evaluate the diagnostic capabilities/benefits of the double contrast barium esophagogram in patients with esophagitis. The sample patients were taken from patients with reflux-type dyspepsia who visited the out patient clinic of the Sub-department of Gastroenterology of the Department of Internal Medicine of the Faculty of Medicine of the University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta. During the duration of study, 32 patients fulfilled the criteria for inclusion, and did not fulfill the criteria for exclusion. All of the subjects underwent double contrast barium esophagogram, Bernstein test, and endoscopy of the upper gastrointestinal tract, as well as biopsy of the lower third esophageal mucosa. The chief complaints for reflux type dyspepsia were found in the following order: pyrosis/heartburn (56.26%), acid/sour taste in the mouth (12.5%), chest pain (9.38%), swallowing disturbance (6.25%), breathing difficulties (6.25%), belching (6.25%), and palpitation (3.12%). From the 32 patients with reflux type dyspepsia that underwent double contrast barium esophagogram, 10 patients (31.25%) were found positive for esophagitis, and the remaining 22 patients were found to be negative (68.75%). Bernstein test found 11 patients (34.37%) positive and 21 (65.63%) negative, while endoscopy of the upper gastrointestinal tract showed positive esophagitis in 25 patients (78.13%) and negative in 7 patients (21.87%). The degree of accordance between double contrast barium esophagogram and the Bernstein test or even a combination of the two was unsatisfactory in diagnosing esophagitis in reflux type dyspepsia. Based on this, this study concludes that double contrast barium esophagogram and Bernstein are incapable of replacing endoscopic examination in establishing the diagnosis of esophagitis. Keywords: esophagitis, esophagogram, Bernstein test
Systematic Review of Clinical Trials of Small‐ and Large‐Gel‐Particle Hyaluronic Acid Injectable Fillers for Aesthetic Soft Tissue Augmentation

BACKGROUND Hyaluronic acid (HA) is the most frequently injected filler for soft tissue augmentation in the United States. OBJECTIVE To systematically review published evidence for aesthetic use of small‐ and large‐gel‐particle HA. METHODS AND MATERIALS Clinical data on anatomic area, level of evidence, patient population, trial design, endpoints, efficacy, and safety were extracted from PubMed. RESULTS Fifty‐three primary clinical reports were analyzed. The highest‐quality efficacy evidence was for the nasolabial folds (NLFs), with 10 randomized, blind, split‐face, comparative trials. Several randomized, blind trials supported treatment of the glabella, lips, and hands. Lower‐level evidence (from studies with nonrandomized, open‐label, or retrospective designs) was recorded for the nasojugal folds (tear troughs), upper eyelids, nose, infraorbital hollows, oral commissures, marionette lines, perioral rhytides, temples, and cheeks. Common adverse events (AEs) across anatomic areas were pain, bruising, swelling, and redness. Serious AEs were uncommon (8 events in 8 patients of 4,605 total patients) and were considered to be unrelated (7 events) or probably unrelated (1 event) to treatment. CONCLUSION The efficacy and safety of small‐ and large‐gel‐particle HA are well established for NLFs; evidence for the glabella, lips, and hands is more limited. Preliminary reports in other anatomic regions suggest efficacy without major complications.
Transforming growth factor‐β1 as a useful serologic marker of small hepatocellular carcinoma

Although alpha‐fetoprotein (AFP) is a useful serologic marker of hepatocellular carcinoma (HCC), it has been reported insufficiently sensitive in detecting small HCCs. Plasma transforming growth factor‐β1 (TGFβ1) has been reported to be elevated in HCC patients compared with liver cirrhosis patients. It has been reported that TGFβ1 mRNA was overexpressed in HCC, especially in patients with small HCC and well‐differentiated HCC compared with patients with liver cirrhosis. The current study investigated the usefulness of TGFβ1 compared with AFP in the diagnosis of small HCCs.
Nutrient potential of blends of malted maize (Zea Mays. L.), African yam bean (Sphenostylis Stenocarpa) and fermented cocoyam (Colocasia Esculenta) flours

This study evaluated the nutrient composition of blends of malted maize, African yam bean and fermented cocoyam. Maize and African yam bean were separately germinated for 48 h. Cocoyam was fermented for the same period. The samples were separately dried and milled to fine flours. Ratios of 70:28:2, 60:38:2 and 50:48:2 (protein basis) of maize (M), African yam bean (AYB) and cocoyam (CY) were used to formulate blends. The blends were chemically analyzed for nutrient composition using standard methods. Porridges prepared from the blends were tested for viscosity. The blend containing M:AYB:CY (50:48:2) had more protein, lipid and minerals but lower carbohydrate and energy. The carbohydrate levels of the blends were higher than that of Nutrend—a commercial weaning food, however, the protein, lipid and minerals were lower. The porridge from M:AYB:CY (70:28:2) mixture had lower viscosity than the porridges from Nutrend and the other blends. The blends have promising nutrient potential as base ingredients for the formulation of complementary food in Nigeria.
Maggot debridement therapy in surgery

Ondanks moderne wondbehandeling en antibiotica, bestaan er nog steeds patienten met chronische wonden. Het ontstaan van antibioticaresistente bacterien, zoals MRSA (Metilcilline-resistente Staphylococcus Aureus), heeft in de laatste 10 tot 20 jaar tot een ware opkomst van behandelingen met maden geleid. Ronald Sherman heeft in 1989 madentherapie als het ware opnieuw ontdekt. Behandeling met steriele maden (Engels: Maggot Debridement Therapy) krijgt een steeds grotere vlucht, ook in Nederland. Het feit dat er, in de laatste tien jaar alleen al, meer dan 100 artikelen over maden zijn verschenen, laat zien dat madentherapie een sterke comeback heeft gemaakt in de geneeskunde. In januari 2004 heeft de Amerikaanse FDA (U.S. Food and Drug Administration), regel 510(k)#33391 uitgegeven, waardoor de productie en verkoop van maden als een medisch apparaat is toegestaan. De International Biotherapy Society heeft haar zevende internationale congres in 2007. Er zijn nu ongeveer 300 centra in Amerika en meer dan 1000 in Europa die madentherapie toepassen. Bewijs in de vorm van multi-center gerandomiseerd onderzoek van behandeling met maden is niet voorhanden. Er zijn drie gerandomiseerde studies naar madentherapie in de literatuur gepubliceerd, de patientenaantallen van de studies waren klein, en de kwaliteit van de studies kon in twee gevallen niet gecontroleerd worden. De studie waarvan de kwaliteit wel gecontroleerd kon worden, ging maar over een totaal van twaalf patienten. Madentherapie heeft, na de introductie in het LUMC in 1999, ook een grote vlucht in Nederland genomen. In 2002 werd in het Rijnland Ziekenhuis een speciale wondenpolikliniek opgericht. Naast vele andere behandelmethoden is daar in 2007 de 150ste patient met maden behandeld. Bij de start van de madentherapie bleken er nog vele basale klinische vragen onbeantwoord. Die vragen vormden de basis voor dit proefschrift.
A Review of the Metabolism of 1,4-Butanediol Diglycidyl Ether–Crosslinked Hyaluronic Acid Dermal Fillers

BACKGROUND Cosmetic procedures are growing ever more common, and the use of soft tissue fillers is increasing. Practicing physicians need to be aware of the biological behavior of these products in tissue to enable them to respond to any safety concerns that their patients raise. OBJECTIVES To provide an overview of the metabolism of 1,4‐butanediol diglycidyl ether (BDDE)‐crosslinked hyaluronic acid (HA) dermal fillers and to examine the safety of the resulting byproducts. METHODS A review of available evidence was conducted. RESULTS After reaction with HA, the epoxide groups of BDDE are neutralized, and only trace amounts of unreacted BDDE remain in the product (<2 parts per million). When crosslinked HA, uncrosslinked HA, and unreacted BDDE degrade, they break down into harmless byproducts or into byproducts that are identical to substances already found in the skin. CONCLUSION Clinical and biocompatibility data from longer than 15 years support the favorable clinical safety profile of BDDE‐crosslinked HA and its degradation products. Given the strength of the empirical evidence, physicians should be confident in offering these products to their patients.
Trabalho e Saúde: um estudo sobre o processo saúde-doença dos servidores de um hospital universitário

Official records show that the number of public servants that retire on health grounds is greater than those in the private sector. We tried to establish a correlation between workloads and stress, and the reasons for absence for treatment among workers of a University hospital. In order to draw a profile of the hospital personnel and establish the contributing factors for absence from work, we used qualitative and quantitative analyses plus a documentary research. Our data show that the main factor leading to the absence from work on health grounds is related more to the general organization and distribution of jobs and responsibilities than the nature of the work. It points to the need to new studies about the different types of work contracts and the process of concession of medical licenses in the public service.
Policy and institutional frameworks : mainstreaming Adolescent Reproductive Health (ARH) and Gender in HIV/AIDS programs : examples from Ethiopia and Uganda

This assessment was conducted in Ethiopia and Uganda in 2005 for a number of reasons. The study has been a part of the World Bank's support to Ethiopia and Uganda, as the low-income countries, in accelerating the achievement of the committed (Millennium Development Goals) MDGs through scaling-up their battle against Human Immunodeficiency Virus (HIV) / Acquired Immunodeficiency Syndrome (AIDS) and facilitating their national poverty reduction strategies. It was also initiated as a part of the Bank's effort to provide assistance to these countries in: (a) assessing the effectiveness of their policies pertaining adolescents, women and HIV/AIDS, and (b) mainstreaming the linkages between ARH and gender in HIV/AIDS interventions. In addition, Ethiopia and Uganda are among the first group of countries that benefited from the multi-country HIV/AIDS Programs of the World Bank in Africa. Finally, tackling issues of ARH and gender in HIV/AIDS programming is vitally important in the context of both Ethiopia and Uganda considering that youth and adolescents not only comprise over thirty percent of their populations, but also are the most affected by HIV/AIDS with young girls bearing the heaviest burden. The overall objective of this study was to develop the capacity of key policy makers, program managers, partners and stakeholders to better understand the linkages between ARH, gender and HIV/AIDS and to increase the participation of vulnerable groups in HIV/AIDS interventions, as the beneficiaries and key stakeholders in policy and decision making for HIV/AIDS programs.
Fractional photothermolysis treatment of digital cutis laxa reverses hand disability

In this case study, we present a safe and novel treatment for a patient with soft tissue hand disability caused by severe and chronic lupus and cutis laxa (CL). This patient was a woman in her 50s with a 20‐year history of systemic lupus erythematous (SLE) and multiple sclerosis who developed hand disability because of the drastic loss of firmness in her soft tissue, extending from the dermis down to the ligaments. The likely cause was CL with SLE synovitis, exacerbated by corticosteroid tapering. Fractional photothermolysis (FP) LASER (Fraxel DUAL 1550/1927; Solta Medical) therapy profoundly alleviated her joint locking in addition to improving the firmness of the overlying skin to reverse her hand disability. This case illustrates a novel approach to CL hand treatment and the profound impact the treatment had on the patient's disabled hand. FP therapy is quick and safe, and its medical application to skin and joints should be further explored.
Long-term follow-up of obstetric studies

This thesis focuses on long-term child follow-up after obstetric studies. Obstetric randomized controlled clinical trials (RCTs) are performed to evaluate the effectiveness of perinatal interventions. However, most often only short-term outcomes are reported, while long-term outcomes are just as important because serious sequelae from perinatal complications frequently manifest themselves only after several years. In this thesis we aimed (1) to assess the current state of affairs concerning follow-up after obstetric RCTs, (2) to explore the possibilities for development of prediction models for different long-term child outcomes using existing cohort data and (3) to discuss the possibilities to formulate a brief guideline for long-term follow-up to facilitate future clinical trialists in their decisions on the need for long-term follow-up.
Occupational sources of stress ; a review of the literature relating to coronary heart disease and mental ill health

Felton & Cole (1963) estimate that all cardiovascular diseases accounted for 12 per cent of the time lost by the ‘working population’ in the US, for a total economic loss of about $4 billion in a single year. A report (1969) by the Department of Health and Social Security in the UK shows, as Aldridge (1970) indicates, that the sum of incapacity for men suffering from mental, psychoneurotic and personality disorders, nervousness, debility and migraine headache accounted for 22·8 million work days lost in 1968 alone (second only to bronchitis in the league table of illness and lost working days). Coronary heart disease and mental ill health together, therefore, represent a serious cost for industry both in human and financial terms.
Plantarflexor muscle ‐ tendon properties are associated with mobility in 1 healthy older adults 2

All material supplied via JYX is protected by copyright and other intellectual property rights, and duplication or sale of all or part of any of the repository collections is not permitted, except that material may be duplicated by you for your research use or educational purposes in electronic or print form. You must obtain permission for any other use. Electronic or print copies may not be offered, whether for sale or otherwise to anyone who is not an authorised user. Plantarflexor Muscle–Tendon Properties are Associated With Mobility in Healthy Older Adults Stenroth, Lauri; Sillanpää, Elina; McPhee, Jamie S. ; Narici, Marco V. ; Gapeyeva, Helena; Pääsuke, Mati; Barnouin, Yoann; Hogrel, Jean-Yves; Butler-Browne, Gillian; Bijlsma, Astrid; Meskers, Carel G. M. ; Maier, Andrea B. ; Finni Juutinen, Taija; Sipilä, Sarianna
A case of penile basal cell carcinoma reconstructed by scrotal myofasciocutaneous flap

Basal cell carcinoma is the most common cutaneous malignant tumor and usually arises from the facial skin and is diagnosed as the solid tumor. However, rarely it arises from genital skin and/or proceeds with ulcerative manner. We report a case of male basal cell carcinoma arising from penile base, which showed urinary disturbance. Tumor resection including total penectomy and skin resection was performed then scrotal myofasciocutaneous flap was used to cover the defect. Scrotal myofasciocutaneous flap was useful for covering the defect in the genital lesion. Moreover, this simple closure was helpful for early postoperative ambulation especially for aged male patients.