Miracle-dz/UniFAR-FTUs huggingface dataset:
Contribution à la modélisation morphofonctionnelle 3D de l'épaule

RERUME: Les modeles personnalises 3D sont de plus en plus demandes pour la planification chirurgicale et les recherches en biomecanique. L’objectif principal de cette these cotutelle etait d’ameliorer la methode de reconstruction 3D a partir des images radiographies biplanes proposee par Lagace, Ohl et al., afin que celle-ci puisse etre plus facilement utilisee en clinique et qu’elle puisse permettre d’aider a la planification chirurgicale et/ou l’evaluation post-chirurgicale. Le systeme de radiographie biplane EOS a faible dose d’irradiation est le resultat d’une collaboration entre la societe EOS imaging, l’institut biomecanique humaine Georges Charpak d’Arts et Metiers ParisTech, le laboratoire de recherche en imagerie et orthopedie (LIO) de l’ecole de technologie superieure de Montreal, Georges Charpak, Jean Dubousset et Gabriel Kalifa (Dubousset et al. 2010). Le principe du detecteur de rayon X est base sur les travaux developpes par le Prof. Charpak, qui reduit significativement la dose de rayonnement compare a la radiographie standard (Dubousset et al. 2010) Quatorze indices cliniques utilises plus ou moins couramment en clinique pour le diagnostic et le suivi des pathologies de l’epaule et pour la planification chirurgicale et son evaluation post-operatoire ont ete calcule. La justesse est acceptable (biais <1 mm sauf la distance sous acrominale) et une reproductibilite (2 fois ecart-type inferieur a 5 mm ou 5° sauf 2 parametres) qui est similaire a ce qui est presente dans la litterature. L’approche proposee apporte sur une amelioration de la reconstruction dans un contexte ou il serait interessant qu’elle devienne utilisable en routine clinique. Bien que les ameliorations soient encore necessaires, cette contribution apporte une pierre a l’analyse de l’articulation intacte et pathologique et est prometteuse quant a la possibilite de son implantation dans la routine clinique pour evaluer les interventions chirurgicales en pre- et post-operatoire.
Targeted sequencing in patients with clinically diagnosed hereditary lipid metabolism disorder and acute coronary syndrome

Истинная распространенность генетических вариантов, стоящих за развитием семейной гиперхолестеринемии (СГХС) и характерных для каждой популяции, остается неизвестной. Целью работы было определение спектра патологических генетических вариантов у больных острым коронарным синдромом (ОКС) с клинически диагностированной СГХС с помощью таргетного секвенирования. Были отобраны 38 из 2081 пациентов двух многоцентровых наблюдательных исследований больных ОКС (2004–2007; 2014–2016 гг.) возрастом ≤ 55 лет (мужчины) и ≤ 60 лет (женщины) с СГХС, клинически диагностированной по критериям Голландской сети липидных клиник и критериям регистра Simon Broome. Молекулярно-генетическое исследование проводили с помощью таргетного секвенирования следующего поколения: сначала секвенировали 3 гена, ассоциированные с СГХС: LDLR, APOB, PCSK9; при отсутствии значимых изменений панель расширяли. Из 38 пациентов у 24 (63,2%) были выявлены генетические изменения, которые могли обусловить клинические проявления СГХС и раннюю манифестацию ишемической болезни сердца. Все пациенты являлись гетерозиготными носителями генетических вариантов. Выявлены варианты в трех основных генах (LDLR, APOB, PCSK9), связанных с СГХС, и редкие варианты в других генах системы липидного обмена (APOE, ABCA1, ABCG5, ABCG8, LPL, ANGPTL3, MTTP). Пять генетических вариантов описаны впервые: патогенный вариант p.Val273_Cys313del гена LDLR; вероятно патогенный вариант p.Arg160His гена APOE; варианты неуточненной клинической значимости p.Glu612Lys и c. *415G>A гена PCSK9; вариант p.Ala776Ser гена LDLR. Таким образом, использование клинических критериев позволяет выявить среди пациентов с ОКС и СГХС носителей мутаций не только «классических» генов, связанных с СГХС, но и редких, способных приводить к фенотипическим проявлениям СГХС.
Proceedings of the First Workshop on Measurement, Privacy, and Mobility

The First Workshop on Measurement, Privacy, and Mobility (MPM'12) will gather researchers to discuss novel ideas about measurement, privacy, and mobility. The ever increasing need for our personal data, location, preferences and interests has raised the bar for regulations and techniques to catch up with the privacy and security aspects of such information. In this workshop we aim to discuss systems, methods, policies and techniques that help in profiling, data mining, offering location based services, while making an attempt in improving privacy preservation. We aim to solicit research papers, work in progress papers and reports from a variety of disciplines, including but not limited to data mining, security, privacy, advertising, epidemics and information dissemination, mobility and location-based data services across academia and industry in order to create a dynamic inter-disciplinary workshop environment.
Le logiciel d'intermédiation: Un panorama critique et réutilisation dans les systèmes d'automatisation enfouis à sûreté de fonctionnement

Le present article resulte de travaux de recherche conduits dans le cadre du projet intitule DepAuDE (Dependability for Embedded Automation Systems in Dynamic Environments with Intra-site and inter-site Distribution Aspects). Tout d'abord est dresse un panorama des principaux logiciels d'intermediation disponibles aujourd'hui; ces logiciels sont analyses des points de vue de la tolerance aux pannes, de la qualite de service et du temps reel. Ensuite, l'article se poursuit par une analyse, d'une part, des exigences pour le projet DepAuDE et, d'autre part, des caracteristiques de solutions existantes qui peuvent etre utilisees, au niveau intra-site ou inter-site, dans l'architecture du systeme faisant l'objet du projet. Afin de tirer parti du travail deja accompli dans le domaine par d'autres equipes de recherche et entreprises, les auteurs ont dresse un panorama de l'etat de l'art en matiere de solutions de logiciel d'intermediation. Ce panorama porte sur des produits connus comme DCE, DCOM, Java RMI et CORBA ainsi que sur certaines approches de la tolerance aux pannes comme Chameleon, ROAFTS, FRIENDS, AQuA et TIRAN.
An interdisciplinary model of context morphology

Using an abstract graph model we describe a hypothetical transformation of a literary entity through the active connections in the graph. First, we weakly define a set of transformations (“morphology”) over a particular entity as a series of the recent activities distinguishing them into categories according to their effect on the entity. Second, to our conjecture, the emerging paths of forms are slowly abandoning the original “birth context”, shaping a decreased, cleaned set of entities, to replace the gap with entities derived from the dynamic set of “recipient context”.
The use of nanotechnology: polyanionic carbosilane dendrimers and antivirals as novel preventive methods against HIV-1 and HCV

The human immunodeficiency virus type 1(HIV-1)/hepatitis C virus (HCV) co-infection remains a growing and evolving epidemic, but new developments and enhanced models offer promising outcomes. Nanotechnology and specially dendrimers are considered emerging and exponential technologies with great potential to develop novel therapeutic and preventive strategies against HIV-1 and HCV infections due to similar sizes with biological structures. The most common way to be infected with HIV-1 is through sexual exposure. In the absence of an effective vaccine, self-applied topical microbicides provide a female-controlled preventive option that not requires negotiation, consent or their partners knowing. Three percent of vaginally-applied G2-S16 microbicide, a polyanionic carbosilane dendrimer (PCD), in humanized BLT mice showed a good safety profile preventing the HIV-1 transmission at 84%. G2-S16 inhibited the HIV-1 infection at early stages by blocking the HIV-1 entry, particularly the gp120/CD4 interaction. G2-S16 inactivated HIV-1 particles by tight binding to HIV-1 envelope proteins provided a barrier to the infection for long periods and prevented the HIV-1 cell-to-cell transmission. With the failure of clinical trials of the non-specific microbicides and that the use of single ARV as vaginal microbicides has not demonstrated to have a sufficient effect, more efforts to develop combinatorial approaches targeting entry and post-replication steps can be the best strategy to prevent the HIV-1 spread. Combinations based on G2-STE16/PCD (G2-S24P or G2-S16), G2-STE16/tenofovir (TFV) and G2-STE16/maraviroc (MRV) or PCD/PCD/PCD, PCD/PCD/TFV, PCD/PCD/MRV and PCD/TFV/MRV showed a synergistic activity profile and a reduction in EC50 against a broad-spectrum of HIV-1 isolates. These combinations maintained their potent anti-HIV-1 activity in the presence of acidic pH and seminal plasma and did not produce vaginal irritation after administration in a BALB/c mouse model. Direct acting agents (DAA) have been successfully developed for the treatment of the chronic HCV infection. However, the lack of a HCV vaccine and the emergence of resistance makes of the development of novel agents an urgent need. By using an unbiased cell-based screening, we identified a family of seven PCD that inhibit the HCVcc infection. PCD inhibited early aspects of the HCV infection, interfered in the HCV entry against HCVpp and bona fide virions from different genotypes, had effect during viral adsorption and did not irreversibly alter the HCV virion infectivity with the exception of G2-S24P. G2-S24P was virucidal at high doses against the HCV infection. In summary, these results suggest that G2-S24P in combination with DAA can be effective antiviral agents, supporting further clinical research on these as potential therapies in the context of blocking the HCV transmission.
Secure Distributed Computing on a Manycore Cloud

Computation outsourcing is an increasingly successful paradigm today. Private and public organizations, as well as common users, can access a large number of economically viable resources to perform the desired computations or access data. The cloud approach allows outsourcers to offer on-demand scalable services to third parties or to perform large computations without high server farm maintenance costs. Scientific computing is one of the beneficiaries of such novel scenarios. Stemming from the first in-house built clusters, distributed computing has flourished over the years also thanks to the Internet. Grids before, and later clouds, have enhanced the storage and computation potentiality. At the same time, to overcome Moore’s law real-world limitations, multicore and manycore hardware has emerged thus allowing parallel computing on a chip. Again, scientific computing in particular has benefited from the speed-up of such novel technology, especially when combined with outsourced cloud computing. As a further opportunity, increasingly powerful mobile devices are now widespread and feature multiple execution cores. They are pervasively immersed in the cloud and can host a large number of applications. These handheld devices can provide additional data acquisition interfaces and pervasive computational resources for heterogeneous workloads. In such a novel scenario it is of primary importance to provide adequate security and privacy guarantees to both providers and users of outsourced services. The problem is complex, as present cloud landscape actors (cloud providers, service providers, and service users) have different requirements and objectives. The first category aims at offering cost-efficient computation while avoiding misuse, the second category aims at reducing costs while at the same time maximizing revenue, the last category aims at reducing the expenses for the accessed services while being guaranteed that the computation is secure, reliable and correct. As a common threat to all these categories lies malicious software, increasingly smart and stealth, affecting a wide range of devices from servers to desktops and even mobile nodes. Such malware can access distributed resources, alter computation outcome and data, leak information. As such, it is of paramount importance to prevent, detect and react to such threats in the smartest possible way.
The differences in functional recovery between HIV-positive and HIV-negative stroke survivors.

Objectives This study aims to identify the differences in functional abilities between stroke survivors who are human immunodeficiency virus (HIV)-positive and HIV-negative. Patients and methods This was a retrospective, longitudinal record review of stroke survivors' files between April 2005 and December 2010. Of a total of 173 stroke survivors who were admitted to the rehabilitation unit, 141 (75 males, 66 females; mean age 52.7±14.3 years; range, 19 to 86 years) met the inclusion criteria. The patients were divided into two groups as HIV-positive (n=21) and HIV-negative (n=120). Functional ability was recorded using the admission and discharge BETA® scores. Results Ischemic strokes were more prevalent than hemorrhagic strokes (74.5% vs. 25.5%, respectively) with hypertension as the most common (31.9%) stroke risk factor. The mean age of stroke onset for HIV-positive patients and HIV-negative patients was 39.6 years and 54.9 years, respectively. In HIV-positive patients, the mean duration of rehabilitation was 7.5-day shorter than HIV-negative patients. After receiving rehabilitation from a multidisciplinary team, the HIV-positive group improved with a mean of 40 points and the HIV-negative group improved with a mean of 38 points. The similarities in functional outcome between the HIV-positive and HIV-negative group were related to the fact that HIV-positive stroke survivors were relatively younger than the HIV-negative group. Conclusion Our study results show that patients who sustain a stroke, are HIV-positive, are receiving antiretroviral therapy and rehabilita- tion may recover similar to those who are HIV-negative, spending a similar length of stay in a rehabilitation clinic. Therefore, stroke survivors who are HIV-positive should receive full rehabilitation similar to any other stroke survivors.
Effect of Ethanolic Extract Fractions of Boerhaavia diffusa in Doxorubicin-induced Myocardial Toxicity in Albino Rats

Background: Doxorubicin is a Anthracycline derivative and has proven efficacy in various malignancies. It is the most effective cytotoxic agent in current use. The clinical usefulness is limited due to its cardiac toxicity. Objectives: To study the preventive role of ethanolic extract fractions of Boerhaavia diffusa (BD) against doxorubicin (Dox) induced myocardial toxicity in albino rats. Methods: The ethanolic extract of whole plant of Boerhaavia diffusa was prepared by hot extraction method and further fractionated into Petroleum ether (PEBD), Chloroform (CLBD), Ethyl acetate (EABD) and Aqueous (AQBD) fractions by increasing in order of polarity. Cardiotoxicity was produced by cumulative administration of Dox (2.5 mg/kg, i.p. alternative day for two weeks). All four fractions (PEBD-20 mg/kg, CLBD-25 mg/kg, EABD-30 mg/kg and AQBD-25 mg/kg) and vitamin E as standard (100 mg/kg) were administered orally as pretreatment for two weeks followed by Dox on alternative days for two weeks. The general observations, biomarker enzymes like lactate dehydrogenase (LDH), Creatine kinase (CK-MB) and Troponin-I (cTnI), biochemical parameters such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were monitored after three weeks of last dose. Myocardial toxicity was also evaluated by histopathologic studies. Results: Repeated administration of Dox-induced cardiomyopathy characterized with an increased level of biomarkers and antioxidant deficit. Pretreatment with the EABD and Vit-E significantly protected myocardium from the toxic effects of Dox by reducing the elevated level of biomarker enzymes like LDH, CK-MB, biochemical parameters such as AST and ALT, absence of cTnI and restoring of disorganized myocardial tissue to normal. Conclusion: The biomarker, biochemical and histopathological data evidently substantiate the cardioprotective effect of EABD, which could be attributed to flavanoids present in the ethyl acetate fraction. Key words: Boerhaavia Diffusa , Cardiotoxicity, Doxorubicin, Troponin-I, CKMB.
Adaptive Transient Leakage-Aware Linearised Model for Thermal Analysis of 3-D ICs

Physics-based models for thermal simulation that involve numerical solution of the heat equation are well placed to accurately capture the heterogeneity of materials and structures in modern 3-D integrated circuits (ICs). The introduction of non-linear effects such as leakage power significantly improves their accuracy. However, this non-linearity increases considerably the complexity and computational time of the analysis. In this paper, we introduce a linearised thermal model by demonstrating that the weak temperature dependence of the specific heat and the thermal conductivity of IC related materials has only minor effect to computed temperature profiles. Thus, these parameters can be considered constant for the operating temperature ranges of modern ICs. The non-linearity in leakage power is approximated by a piecewise linear least square fit and the resulting model is linearised by exact Newton’s method. The method is applied to transient thermal analysis with adaptive time step selection, where we demonstrate the importance of applying Newton corrections to obtain the right time step size selection. The resulting method is typically 2 − 3× faster than a full non-linear method with a global relative error of less than 1%.
Obesity and pregnancy: overcoming the communication barriers

Obesity prevalence and impact You would be hard pressed to miss the message that obesity represents a serious risk to health and has increased markedly in the UK in recent years. Perhaps less well recognised are health concerns for women who enter pregnancy with a Body Mass Index (BMI; weight/height) over 30 (kg/m) (the clinical threshold for obesity) or who gain excessive weight during pregnancy. In the UK the prevalence of obesity among women of childbearing age increased from 12% to 20% between 1993 and 2010, and in 2009 approximately 5% of all pregnancies in England (more than 38,000 per year) were associated with a maternal BMI of over 35. In addition, all women are vulnerable to excessive weight gain during pregnancy.
Temporal bone partial ostectomy via the temporomandibular joint to treat osteosarcoma of the caudal zygoma in a three-year-old Labrador retriever

A three years, seven-month-old male entire Labrador retriever was referred with a one-month history of pain when yawning and eating. CT revealed a 20×10×10 mm mass in the region of the left caudal zygoma. CT-guided biopsy results identified a florid periosteal reaction but were otherwise inconclusive. Surgery was performed to resect the left caudal zygoma via the temporomandibular joint. Further histopathological results confirmed completely resected osteogenic osteosarcoma with narrow margins. No other treatment modalities were pursued. The dog remained free from clinical signs until 28 months following surgery when local tumour growth and thoracic metastases were diagnosed.
Exploring Distributed Cognition Collaborative Group Learning on Interactive Tabletop Displays

Learning and education are research fields with a myriad of different theories, frameworks and methods. They cover everything from the traditional classroom session to how the population of a whole country learns over decades. One specific type of learning is how a small group of people sitting around a table solving problems learn from each other and the material at hand. This type of learning is often modeled as Distributed Cognition learning. Specifique AS develops a type of paper tool that fits right into the Distributed Cognition category of learning and has been working on it for over 20 years. Their wish is to re-­‐imagine this tool in digital form to improve its function. Taking analog tools and improving them by making them digital has a very successful history, and making this specific kind of learning digital is a relatively unexplored field. It is just now that this kind of technology is cheap enough and readily available to make it feasible for a bigger market. There is a clear opportunity to break new ground. Touchtech AB is a Gothenburg based company that focuses on multi-­‐touch and other NUI solutions to various problems. Utilizing their and Specifique's knowledge in their respective fields the goal of this thesis is to take a step in the direction of how to design a new tabletop display based DC learning tool. The method used is a variation of a Goal Directed design method. Starting with scope definition, stakeholder interviews, audit of existing work, user observations, design phase and user tests. This was conducted in two iterations. The final results of the thesis are a set of key design considerations for designing tabletop display DC learning tools. Because of the thesis' limited scope it is difficult to draw any general conclusions on the benefit of using a digital tool instead of an analog one, but the results seem to indicate that using a digital tabletop display instead of a analog has clear benefits. Mainly by giving designers more tools in their toolbox to shape the user experience. The design considerations in this thesis is a list of guidelines that help designers use those tools in the right way to facilitate DC learning.
A case report of accidental extrusion of sodium hypochlorite into the maxillary sinus during endodontic retreatment and review of current prevention and management

A case is presented of a patient attending with a sodium hypochlorite (NaOCl) accident of the left maxillary sinus during endodontic retreatment of a maxillary molar tooth. Sodium hypochlorite accidents are relatively uncommon but when they occur there is potential for severe complications. A literature review has been carried out reviewing current recommendations to reduce the likelihood of a sodium hypochlorite accident and the management of a sodium hypochlorite accident if occurs.
Design and implementation of an “Web API” for the automatic translation Colombia's language pairs: Spanish-Wayuunaiki case

This paper presents the design and implementation of an Application Programming Interface (API) that allows exposing the service of automatic translation between two languages (Spanish and Wayuunaiki case) using a evolving development model based on prototypes and through solutions based on open source technologies. This innovative development uses the Information Technology and Communication (ICT) to focus on Aboriginal languages translation enhancing the integration of technology with communities and allowing inclusion of languages and cultures conserving in the ICT ecosystem in Colombia. During the development of this document It will describe how various open source (Python 2.7, Apertium, SO Ubuntu Linux 12.04 LTS 64 Bits Server Edition, Apache Web Server con mod_wsgi, PostgreSQL 9.1,Gunicorn, Django 1.4) tools were integrated to achieve the goal of creating an API with a reproducible architecture in various environments, which complies with current trends and technical requirements for web implementation, such as usability, scalability, simple and clear code, and others. Finally we developed a web application that allows knowing and validating the functionality of the API implemented.