Miracle-dz/UniFAR-FTUs huggingface dataset:
Border Medicine: A Transcultural History of Mexican American Curanderismo. By Brett Hendrickson

sented in historical and archival records and scholarly research. Dobransky’s inclusion of client interviews in his analysis shows that clients possess important situated knowledge. The analysis put forth suggests that clients’ experiences are as important as those of doctors and other mental health care workers to understand treatment administered to individuals with SPMI, and to understand more generally the mental health care system in the United States. Another advantage of both ethnography and oral history is that both have the potential to challenge dominant hierarchies of power by welcoming alternative narratives of events and experiences (see, for example, Katherine Fobear, “‘I Thought We Had No Rights’—Challenges in Listening, Storytelling, and Representation of LGBT Refugees” [Studies in Social Justice 9, no. 1, 2015]). An important contribution of Dobransky’s book is that it raises questions about authority and expertise in the mental health care system. Dobransky interviewed health care workers with a variety of professional expertise. While some workers had obtained educational credentials, others had lived experience of mental illness obtained by working with clients. The book shows that these different types of workers may relate to clients with the same or similar problems in dissimilar ways. This is important given that clients are socially constructed as good, bad, or symptomatic patients, and treated based on their interaction with workers. Dobransky’s book is slim, but readers should not mistake it for an easy read. At times, it is difficult to keep track of examples from and comparisons across the two field sites. Overall, the book provides important insights into the challenges workers and clients face in the mental health care system. Sociologists and mental health care professionals, including policy makers, will find Dobransky’s work of particular interest. Oral historians interested in questions of authority and expertise or documenting mental health care workers and clients will also enjoy this book.
E‐cadherin expression in human epithelial ovarian cancer and normal ovary

The ovarian surface epithelium (OSE) is the origin of the majority of human ovarian cancers. These adenocarcinomas are characterized by initial local growth followed by spreading into the peritoneal cavity at later stages of tumor progression. The cell‐adhesion molecule E‐cadherin (E‐cad) plays an important role in maintaining tissue integrity. Disappearance or impaired function of E‐cad have often been associated with tumor formation and invasion in vivo and in vitro. The cell‐specific expression of E‐cad was investigated in normal human ovaries (n = 12), in benign (n = 5) and borderline (n = 4) ovarian epithelial tumors and in adenocarcinomas of different stages and histological grades (n = 18), by immunohistochemistry and immunoblotting. An ovarian cancer cell line (NIH‐OVCAR3) was used as a reference. The epithelial origin of the cells was confirmed with cytokeratin (AE1/AE3) staining. In normal ovaries, the expression of E‐cad was limited to inclusion cysts or deep clefts lined with OSE, whereas no staining of the OSE could be demonstrated at the surface of the ovary. In contrast, benign and borderline tumors uniformly expressed E‐cad. This was observed in malignant tumors of all stages despite their degree of differentiation. E‐cad was also present in metastasis from such tumors. The cell‐specific expression of E‐cad in inclusion cysts of normal ovaries and in epithelial layers of borderline tumors indicates a role for E‐cad in the early events of the progression to a malignant phenotype. E‐cad was not downregulated in later stages of ovarian cancer progression. Int. J. Cancer 74:275‐280, 1997. © 1997 Wiley‐Liss, Inc.
Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner

An unresolved question regarding the RNA-recognition motif (RRM) protein Half pint (Hfp) has been whether its tumour suppressor behaviour occurs by a transcriptional mechanism or via effects on splicing. The data presented here demonstrate that Hfp achieves cell cycle inhibition via an essential role in the repression of Drosophila myc (dmyc) transcription. We demonstrate that regulation of dmyc requires interaction between the transcriptional repressor Hfp and the DNA helicase subunit of TFIIH, Haywire (Hay). In vivo studies show that Hfp binds to the dmyc promoter and that repression of dmyc transcription requires Hfp. In addition, loss of Hfp results in enhanced cell growth, which depends on the presence of dMyc. This is consistent with Hfp being essential for inhibition of dmyc transcription and cell growth. Further support for Hfp controlling dmyc transcriptionally comes from the demonstration that Hfp physically and genetically interacts with the XPB helicase component of the TFIIH transcription factor complex, Hay, which is required for normal levels of dmyc expression, cell growth and cell cycle progression. Together, these data demonstrate that Hfp is crucial for repression of dmyc, suggesting that a transcriptional, rather than splicing, mechanism underlies the regulation of dMyc and the tumour suppressor behaviour of Hfp.
2 Molecularbiology of Basal Cell Carcinoma

Basal cell carcinoma is the most frequently occurring skin tumor. Most cases are not life threatening. Only a very small proportion of BCCs metastasize. A high tendency to recurrence makes characterizing BCCs and tumor margin areas obligatory. It will assist in better understanding their pathogenesis and in more effective treatment through prevention of recurrence and second primary disease. In addition to histopathological assessment, the spread of the primary tumor according to TNM classification is crucial for estimating the further development of the disease.
The Innervation of the Pelvic and adjoining Viscera

WE stated in Part IV. that stimulation of the sacral nerves has no observable effect on the internal generative organs, and from this we concluded that the sacral nerves send no efferent fibres to these organs. It seemed to us imperative to test this conclusion in some other way, and if it were confirmed, it seemed highly desirable to ascertain also whether the internal, generative organs are or are not supplied with afferent fibres by the sacral nerves. The obvious way of applying a test, was to cut the sacral nerves and to observe microscopically the course of the degenerating nerve fibres. We have accordingly nmade five experiments, as follows:
Study on the fluctuation characteristics of the yield rate of stocks of Chinese listed companies in the agricultural sector

This paper studied the fluctuation characteristics of the yield rate of stocks of Chinese listed companies in the agricultural sector through empirical analysis. 36 listed agricultural industrialization companies in the main board market of Shanghai Stock Exchange are taken as samples for data collection, and descriptive statistics, modeling and ARCH test method are applied to describe the fluctuation characteristics of the yield rate of stocks of the listed companies in the agricultural sector. Finally, it is found that the yield rate of stocks of listed agricultural companies is characterized by sharp peak and fat tail in the yield curve, heteroscedasticity, continuity in fluctuation, asymmetry, as well as ARCH effect.
Beyond the Prisoner's Dilemma: Toward Models to Discriminate among Mechanisms of Cooperation in Nature

Lee Alan Dugatkin is at the Dept of Biology, Mount Allison University, Sackville, New Brunswick, Canada EOA 3C0 (from I luly 1992: T.H. Morgan School of Biological Sciences, University of Ken- tucky, Lexington, KY 40506-0225, USA); Michael Mesterton-Gibbons is at the Dept of Mathematics B-154, Florida State University, Tallahassee, FL 32306, USA; Alasdair Houston is at the Dept of Zoology, University of Oxford, South Parks Road, Oxford, UK OXI 3PS.
Health benefits of gastric bypass surgery after 6 years.

CONTEXT Extreme obesity is associated with health and cardiovascular disease risks. Although gastric bypass surgery induces rapid weight loss and ameliorates many of these risks in the short term, long-term outcomes are uncertain. OBJECTIVE To examine the association of Roux-en-Y gastric bypass (RYGB) surgery with weight loss, diabetes mellitus, and other health risks 6 years after surgery. DESIGN, SETTING, AND PARTICIPANTS A prospective Utah-based study conducted between July 2000 and June 2011 of 1156 severely obese (body mass index [BMI] ≥ 35) participants aged 18 to 72 years (82% women; mean BMI, 45.9; 95% CI, 31.2-60.6) who sought and received RYGB surgery (n = 418), sought but did not have surgery (n = 417; control group 1), or who were randomly selected from a population-based sample not seeking weight loss surgery (n = 321; control group 2). MAIN OUTCOME MEASURES Weight loss, diabetes, hypertension, dyslipidemia, and health-related quality of life were compared between participants having RYGB surgery and control participants using propensity score adjustment. RESULTS Six years after surgery, patients who received RYGB surgery (with 92.6% follow-up) lost 27.7% (95% CI, 26.6%-28.9%) of their initial body weight compared with 0.2% (95% CI, -1.1% to 1.4%) gain in control group 1 and 0% (95% CI, -1.2% to 1.2%) in control group 2. Weight loss maintenance was superior in patients who received RYGB surgery, with 94% (95% CI, 92%-96%) and 76% (95% CI, 72%-81%) of patients receiving RYGB surgery maintaining at least 20% weight loss 2 and 6 years after surgery, respectively. Diabetes remission rates 6 years after surgery were 62% (95% CI, 49%-75%) in the RYGB surgery group, 8% (95% CI, 0%-16%) in control group 1, and 6% (95% CI, 0%-13%) in control group 2, with remission odds ratios (ORs) of 16.5 (95% CI, 4.7-57.6; P < .001) vs control group 1 and 21.5 (95% CI, 5.4-85.6; P < .001) vs control group 2. The incidence of diabetes throughout the course of the study was reduced after RYGB surgery (2%; 95% CI, 0%-4%; vs 17%; 95% CI, 10%-24%; OR, 0.11; 95% CI, 0.04-0.34 compared with control group 1 and 15%; 95% CI, 9%-21%; OR, 0.21; 95% CI, 0.06-0.67 compared with control group 2; both P < .001). The numbers of participants with bariatric surgery-related hospitalizations were 33 (7.9%), 13 (3.9%), and 6 (2.0%) for the RYGB surgery group and 2 control groups, respectively. CONCLUSION Among severely obese patients, compared with nonsurgical control patients, the use of RYGB surgery was associated with higher rates of diabetes remission and lower risk of cardiovascular and other health outcomes over 6 years.
Presence of the Paternal Pronucleus Assists Embryo in Overcoming Cycloheximide Induced Abnormalities in Zygotic Mitosis

After fertilization, the maternal and paternal chromosomes independently proceed through pronuclear formation. These chromatin reconfigurations occur within a shared cytoplasm thus exposing both gametes to the same factors. Here, we report that continuous cycloheximide [40 μg/mL] treatment of parthenogenotes, androgenotes, and ICSI embryos reveals ORC2 pronuclear instability in the maternal (MPN) but not the paternal pronucleus (PPN). When released from CHX after 8 h, the MPN can recover ORC2 and proceed through replication, however, parthenogenotes encounter severe mitotic defects while both ICSI embryos and androgenotes are able to recover and develop at significantly higher rates. Taken together, these data suggest cycloheximide treatment promotes an environment that asymmetrically affects the stability of ORC2 on the MPN, and the ability of the MPN to develop. Furthermore, the presence of the PPN in the zygote can ameliorate both effects. These data suggest further evidence for crosstalk between the two pronuclei during the first cell cycle of the embryo. J. Cell. Biochem. 117: 1806–1812, 2016. © 2016 Wiley Periodicals, Inc.
[Effect of combined therapy using complex of natural cytokines and antimicrobial peptides in urogenital infections caused by Chlamydia and Mycoplasma].

AIM To study efficacy of complex therapy of urogenital infections caused by Chlamydia and Mycoplasma using immunomodulator Superlimph. MATERIALS AND METHODS Fifty males and thirty six females ages 22 - 47 years old with chronic urogenital infections--cervicitis and vulvovaginitis (females), prostatitis (males)--were studied. PCR and bacteriologic methods were used for diagnostics of mixed infection and microbiota efficiency. Patients were divided on 3 groups according to treatment protocol. Twenty patients (group 1)--standard therapy (josamycin), 48 patients received immunomodulator (suppositorium) before treatment with josamycin (group 2), 18 patients were simultaneously treated with josamycin and immunomodulator (group 3). RESULTS Combinations of Chlamydia trachomatis, Ureaplasma urealyticum, Gardnerella vaginalis and Mycoplasma genitalium were identified in 30 - 35% of cases before treatment. After treatment with josamycin (group 1) or simultaneous therapy with josamycin and immunomodulator (group 3) considerable suppression of growth and elimination of both main pathogens and members of microbiota. Use of immunomodulator (group 2) in some cases resulted elimination of main pathogens and associated opportunistic microflora. CONCLUSION Microbiological monitoring in 97% cases demonstrated therapeutic effect of immunomodulator Superlymph on urogenital infections associated with Chlamydia and Mycoplasma and disbiotic microbiota of urogenital tract.
Tracking control of differential mobile robots using adaptive coupling scheme

In this paper, a new adaptive coupling control algorithm is developed to synchronize motions of two driving wheels of a differential mobile robot so that the robot maintains in the desired trajectory path. Unlike considerable approaches in the literature, in this study motion of driving wheels instead. of the robot configuration are directly controlled in a synchronous manner. This strategy avoids the involvement of nonholonomic constraint in the control design, and therefore simplifies the practical implementation significantly. The proposed controller incorporates the cross-coupling technology into adaptive control architecture, and guarantees asymptotic convergence to zero of both position tracking error and the synchronization error. Experiments have been conducted to verify the effectiveness of the proposed control approach.
Two Presentations of Contact Lens-Induced Papillary Conjunctivitis (CLPC) in Hydrogel Lens Wear: Local and General

Purpose. The purpose of this study was to confirm that two distinct clinical presentations of contact lens-induced papillary conjunctivitis (CLPC), local and general, occur in hydrogel lens wear. Methods. Retrospective analyses of 124 CLPC events were identified. The classification of CLPC was based on location and extent of papillae. CLPC was classified as local if papillae were present in one to two areas of the tarsal conjunctiva and general if papillae occurred in three or more areas. The CLPC events were compared with an asymptomatic control group in prospective clinical trials conducted from 1993 until 2003 at two clinical sites, Australia and India. Two hundred sixteen subjects from Australia and 914 subjects from India wore either high Dk silicone hydrogel or low Dk hydrogel lenses on a 6-night (6N) or 30-night extended-wear (EW) schedule. The physiological responses of the ocular surface, including tarsal conjunctiva redness and roughness, number of papillae present, lens fit and performance, and subjective patient symptoms, were measured during each visit at each site. These variables listed were compared between local CLPC groups and asymptomatic controls and general CLPC groups and asymptomatic controls. Results. Two types of CLPC in hydrogel lens wearers have been confirmed. Of the 124 CLPC events, there were 61 local and 63 general events. Local and general CLPC cases reported significantly greater frequency of symptoms compared with the asymptomatic controls, in particular itching, lens awareness, secretion, and blurred vision (p < 0.1). Conclusions. The classification of CLPC into two types, local and general, in hydrogel lens wear was confirmed based on presentations at both sites. This distribution of papillae between local and general CLPC may indicate separate etiologies involved in the pathogenesis of the condition.
Integro-Differential Harmonic Maps into Spheres

For s ∈ (0, 1) we introduce (integro-differential) harmonic maps v: Ω ⊂ ℝ n → ℝ N , which are defined as critical points of the Gagliardo/Slobodeckij energy with the condition that v(Ω) ⊂ 𝕊 N−1, for the (N − 1)-sphere 𝕊 N−1 ⊂ ℝ N . If p = 2 these are the classical fractional harmonic maps first considered by Da Lio and Rivière. For p ≠ 2 this is a new energy which has degenerate, non-local Euler-Lagrange equations. They are different from the n/p-harmonic maps introduced by Da Lio and the author, and have to be treated with new arguments, which might be of independent interest for further applications on geometric energies. The main result is Hölder continuity for these maps in the critical case .
Protagonist: Should we eradicate Helicobacter pyloribefore long term antireflux therapy?

Patient management recommendations that might become health care policy should be based on the highest level of evidence. The evidence supporting the recommendation to “test and treat” for Helicobacter pylori infection before starting long term antireflux treatment falls well short of this standard. This recommendation arose directly from the report by Kuipers and colleagues1 in 1996 that the prevalence of corpus glandular atrophy increased during chronic omeprazole treatment in patients infected with H pylori . We were pleased to have another reason to eradicate H pylori ; the prevailing wisdom was that no H pylori should go unpunished. This aggressive approach has been challenged, particularly in the case of patients with gastro-oesophageal reflux disease (GORD). Approximately 42% of adults in the USA suffer from GORD.2 Nearly 7% experience heartburn on a daily basis,3 making them potential candidates for proton pump inhibitor (PPI) therapy and, therefore, testing for H pylori infection. Apart from the obvious economic and antimicrobial resistance implications, growing evidence indicates that H pylori infection protects against the complications of …
Dynamic neointimal pattern after drug-eluting stent implantation defined by optical coherence tomography

Objectives Certain neointimal patterns including neoatherosclerosis (NA) are known to be associated with poor clinical outcome. The prevalence and time course of different neointimal patterns have not been studied systematically. The aim of this study was to investigate the serial changes in neointimal pattern after drug-eluting stent implantation. Patients and methods A total of 132 patients with 207 drug-eluting stents, who underwent two follow-up optical coherence tomography studies at 6 and 12 months, were included. Neointimal patterns were categorized as homogeneous, heterogeneous, layered, or NA using optical coherence tomography. Quantitative and qualitative analyses of neointima were carried out. Results Both at 6 and at 12 months, the homogenous neointima was the predominant type (>75%), followed by the layered and the heterogeneous pattern. At 12 months, progression to NA was observed in 0.6% of the patients in the homogeneous group, in 5.6% of the patients in the heterogeneous group, and in 3.9% of the patients in the layered group. Regression to the homogeneous pattern was observed in 5.6% of the patients in the heterogeneous group and 11.5% of the patients in the layered group. Conclusion The homogenous neointima is the predominant pattern both at 6 and at 12 months. The neointimal pattern changed between 6 and 12 months in 10.6% of stents. Further studies are needed to understand the mechanisms of these neointimal changes and their clinical significance.
Near-Roadway Air Pollution and Coronary Heart Disease: Burden of Disease and Potential Impact of a Greenhouse Gas Reduction Strategy in Southern California

Background Several studies have estimated the burden of coronary heart disease (CHD) mortality from ambient regional particulate matter ≤ 2.5 μm (PM2.5). The burden of near-roadway air pollution (NRAP) generally has not been examined, despite evidence of a causal link with CHD. Objective We investigated the CHD burden from NRAP and compared it with the PM2.5 burden in the California South Coast Air Basin for 2008 and under a compact urban growth greenhouse gas reduction scenario for 2035. Methods We estimated the population attributable fraction and number of CHD events attributable to residential traffic density, proximity to a major road, elemental carbon (EC), and PM2.5 compared with the expected disease burden if the population were exposed to background levels of air pollution. Results In 2008, an estimated 1,300 CHD deaths (6.8% of the total) were attributable to traffic density, 430 deaths (2.4%) to residential proximity to a major road, and 690 (3.7%) to EC. There were 1,900 deaths (10.4%) attributable to PM2.5. Although reduced exposures in 2035 should result in smaller fractions of CHD attributable to traffic density, EC, and PM2.5, the numbers of estimated deaths attributable to each of these exposures are anticipated to increase to 2,500, 900, and 2,900, respectively, due to population aging. A similar pattern of increasing NRAP-attributable CHD hospitalizations was estimated to occur between 2008 and 2035. Conclusion These results suggest that a large burden of preventable CHD mortality is attributable to NRAP and is likely to increase even with decreasing exposure by 2035 due to vulnerability of an aging population. Greenhouse gas reduction strategies developed to mitigate climate change offer unexploited opportunities for air pollution health co-benefits. Citation Ghosh R, Lurmann F, Perez L, Penfold B, Brandt S, Wilson J, Milet M, Künzli N, McConnell R. 2016. Near-roadway air pollution and coronary heart disease: burden of disease and potential impact of a greenhouse gas reduction strategy in Southern California. Environ Health Perspect 124:193–200; http://dx.doi. org/10.1289/ehp.1408865
Pituitary responsiveness to LRH in the short-term ovariectomized rat.

A single injection of estradiol benzoate (Eb, 5 ugh00 g body weight) to rats ovariectomized (Ovx) 48 h earlier induces daily afternoon surges of LH. The objective of the present study was to test the possibility that changes in pituitary responsiveness to LRH could account, in part at least, for the diurnal rhythm in LH release and for the diminution in the LH response with time after Eb treatment in the 48 h-Ovx rat. It also investigates the effects of exogenous LRH on the Eb-induced LH surge. The results show that Eb was effective in eliciting an afternoon surge of LH 1 and 2 days after treatment while morning levels remained low, and that the LH response was clearly reduced by the second day after Eb treatment. Although estrogen caused a minimal increase in pituitary responsiveness to LRH, the responsiveness did not prove significantly different when tested in pentobarbital blocked animals either a) in the morning (1000) and afternoon (1700) of the same day after Eb treatment, orb) in the afternoon of Days 1 and 2 after Eb injections. This stability in pituitary responsiveness to LRH was maintained in spite of dramatic differences in LH levels at these times. Studies on the priming effects of exogenous LRH showed that the Eb-induced LH surge could be significantly potentiated by giving a morning injection of 100 ng LRH; curiously, rats receiving 200 ng LRH showed an LH response similar to that of the saline control animals. These results suggest that after estrogen has sensitized the pituitary to LRH, the responsiveness remains stable for at least 2 days, but that an appropriate dose of LRH can further sensitize the pituitary to endogenous LRH. These findings support the hypothesis that the daily LH surges in Ovx rats are controlled primarily by neural mechanisms that require estrogen for their expression.