Miracle-dz/UniFAR-FTUs huggingface dataset:
Circulating BRAFV 600 E in the Diagnosis and Follow-Up of Differentiated Papillary Thyroid Carcinoma

Endocrinology Unit (C.P., B.F., M.R., L.P., M.L.D.F., G.F.), Careggi University Hospital, 50141 Florence, Italy; Clinical Biochemistry Unit (P.P., F.S., M.P., C.O.), Department of Biomedical, Experimental, and Clinical Sciences, University of Florence, 50139 Florence, Italy; Department of Medical and Surgical Critical Care (G.P.), Careggi University Hospital, 50141 Florence, Italy; and Department of Medical and Surgical Critical Care (V.V.), Division of Pathological Anatomy, Careggi University Hospital, 50141 Florence, Italy
Investigation of Pile-Up and Delamination of Au Thin Films on Various Substrates and the Behavior of the Films Described by a Discontinuous Elastic Strain Model

ii Acknowledgments . iii List of Tables . vi List of Illustrations . vi List of Abbreviations . x Chapter 1: Introduction . 1 1.1 Overview . 1 1.2 Thesis Structure . 2 Chapter 2: Literature Review of Instrumented Thin Film Indentation . 3 2.1 Instrumented Indentation Testing . 3 2.2 Continuous Stiffness Measurement . 7 2.3 Erroneous Contact Area . 10 2.4 Modeling Thin Film Substrate Effects . 12 Chapter 3: Material Selection . 20 3.1 Material Selection and Their Mechanical Properties . 20 Chapter 4: Experimental Setup and Fabrication . 21 4.1 Film Deposition . 21 4.2 Nanoindentation . 26
Morphology and Thermal Properties of Core-Shell PVA/PLA Ultrafine Fibers Produced by Coaxial Electrospinning

Coaxial electrospinning process was used to produce biodegradable membranes made of coreshell fibers of a poly(lactic acid) (PLA) shell and a poly(vinyl alcohol) (PVA) core. Scanning electron microscopy analyses of these structures showed that the PLA shell can present certain porosity depending on the process condition. FTIR-ATR and contact angle measurements also suggested imprisonment of the PVA core within the PLA shell. This type of structure was also confirmed by means of transmissions electron microscopy. The morphology of these fibers was dependent on the flow rate of both core and shell solutions, and homogeneous and smooth surface was only attained when the flow rate of the external PLA solution was 4 times the flow rate of the internal PVA solution. The increase in the PLA solution flow rate increases the diameter of the core-shell fiber which reaches up to 1.7 μm. Nevertheless, fibers with smaller average diameter could also be produced (200 nm). These core-shell fibers presented improved hydrophilicity as compared with monolithic PLA fibers.
Optimization of Process Parameters for Siderophore Production Under Solid State Fermentation Using Polystyrene Beads as Inert Support

Kuttanad, commonly called the rice bowl of Kerala, is noted for its paddy cultivation well below sea level. Decrease in micro and macro nutrients is a common phenomenon in all agricultural lands and the micro-biota plays a major role in maintaining soil fertility of agrarian regions. Iron is one of the most common limiting trace elements in nature which is essential for the growth and metabolism of almost all living organisms. Deficiency of iron is primarily due to its poor solubility. Bacteria secrete iron chelating agents known as siderophores to absorb iron, which promotes plant growth. In the present study, soil and water samples from Kuttanad were screened for siderophore producing bacteria. Ten siderophore producing bacteria were isolated from the soil and water environments by primary screening. Secondary screening using Chrome Azurol Sulphonate agar was done to confirm siderophore producers. A Pseudomonas strain isolated from the soil was selected for siderophore production under solid state fermentation using polystyrene beads as inert support. Process parameters of the fermentation process along with additional carbon, nitrogen and amino acid sources were optimized so as to increase the production of siderophores. Succinate medium of pH 8, incubation temperature of 35 o C and incubation time of 48 hours were proved optimum for siderophore production. 0.5% v/w glycerol, 0.5% w/w ammonium chloride and 2.5 % w/w L-asparagine were the carbon, nitrogen and amino acid sources which gave maximum siderophore production respectively. This is the first study of its kind and has tremendous potential for further research.
Ultra-violet Spectrophotometric Determination of Caffeine in Soft and Energy Drinks Available in Yenagoa, Nigeria

This study was carried out to determine the pH and levels of caffeine in eight brands of carbonated and energy drinks available in local market in Yenagoa, Nigeria. Quantitative analysis of caffeine was performed by a simple and fast standard UV spectrophotometric method, using carbon tetrachloride as the extracting solvent. Results showed that the pH of the beverages were slightly acidic ranging from 5.92-6.44. The minimum caffeine level was observed in the carbonated soft drink Coca Cola (43.71±0.55 ppm), while the energy drink, Red Bull sample showed the highest caffeine content (58.31±0.35 ppm). The carbonated soft drinks showed caffeine levels in the range of 43.71 and 45.83 ppm with average concentration of 44.52 ppm, whereas in the energy drinks it ranged from 47.56 to 58.31 ppm with a mean concentration of 52.24 ppm. The caffeine content in all the beverage samples analyzed in this study are well below the maximum allowable limits set by the US Food and Drugs Administration.
ANALYSIS OF THE EXPRESSION OF FAS/CD95 AND HSP70 IN LOW AND HIGH GRADE UROTHELIAL CELL CARCINOMA OF THE BLADDER

Urothelial Cell Carcinoma (UCC), also called transitional cell carcinoma of the bladder, is the most common malignancy in urinary tract. The prognosis of this disease is highly dependent on the histological grading at diagnosis. Fas/CD95 has a role in apoptotic process, whereas HSP70 has an antiapoptotic role. This study aimed to analyze the expression of Fas/CD95 and HSP70 in low grade and high grade urothelial cell carcinoma in the bladder. This was an analytic observational study with cross sectional approach. Population and sample were paraffin blocks of urothelial cell carcinoma in the Laboratory of Anatomic Pathology, Dr. Soetomo Hospital, Surabaya in the period of January 2011-December 2016. Each grading of urothelial cell carcinoma was randomly sampled. Immunohistochemystry with Fas/CD95 and HSP70 were performed. Expression of Fas/CD95 and HSP70 were assessed semiquantitatively. Expression of Fas/CD95 and HSP70 were analyzed using Mann-Whitney test and Spearman test. The results showed there was significant different in expression of Fas/CD95 and HSP70 in low and high grades in urothelial cell carcinoma. There was no significant correlation between the expression of Fas/CD95 and HSP70 in urothelial cell carcinoma. As a conclusion, the role of CD95 and HSP70 expression can be useful as marker for the diagnosis, especially in the determination of the grade of differentiation.
The effects of institutional change on innovation and productivity growth in the Swedish pharmaceutical industry

The relation between innovative output from the R&D process and total factor productivity (TFP) in the Swedish pharmaceutical industry has been investigated. The focus has been on the 1960s when the institutional conditions for innovation changed drastically in the pharmaceutical industry through new and stricter regulation. The short term effect of the new regulation was a shift towards quality products. Patenting increased and there were an increasing number of economically successful drugs based on new substances (NCEs). This had a positive impact on TFP growth.
The effect of sago pith waste granule compost and inorganic fertilizer on soil physical characteristics and corn (Zea mays L.) production in Inceptisol

The study aimed to determine the effect of sago pith waste granule compost and inorganic fertilizers on soil physical characteristics and the results of corn in Inceptisol. The research design used in this study was a randomized block design with three replications. Treatment consisted of: no fertilizer (KGES1), with granule 8 t ha -1 compost (KGES2), inorganic fertilizer (Urea, SP - 36, and KCl), recommended dosage (KGES3), inorganic fertilizer + granule 8 t ha - compost ( KGES4 ), ½ x dose of inorganic fertilizer + compost granule (8 t ha -1 ) (KGES5) , 2 doses of inorganic fertilizer + granule 8 t ha -1 compost (KGES6), ½ x dose of inorganic fertilizer + 12 t ha -1 granule compost (KGES7) and 2 times the dose of inorganic fertilizer + 4 t ha compost (KGES8). The results showed that sago pith waste granule compost and inorganic fertilizers significantly affect the physical characteristics of the soil that is categorized into heavy volume of soil (0.80 g cm -3 ), soil particle density (2.30 g cm -3 ), soil porosity (7.77 %), fast drainage pore (23:54 %), slow drainage pore (8.83 %), available water pore (11.62 %), and unavailable water pore (11:31). On the other hand, the plant growth (plant height) and dry shelled corn grain results amounted to 249.17 cm and 7.85 tones ha -1 . The combination of sago pith waste granule compost and inorganic fertilizer may improve the results of 30-47 % better compared to inorganic fertilizer or granule compost alone. Excessive inorganic fertilizer did not show the significant increase of dry shelled corn seeds productions. Based on these results, the reduction of a half dose of inorganic fertilizer combined with 12 t ha -1 granule compost yielded of dry shelled corn grain of the highest (7.85 t ha -1 ) or in percentage the increase of the results of 32 % of inorganic fertilizer application.
INVESTIGATING THE EFFECT OF CUSTOMER KNOWLEDGE MANAGEMENT AND ELECTRONIC MARKETING ON ORGANIZATIONS DEVELOPMENT

Information Technology, by facilitating the relationship with customers as well as its speed and effectiveness, paves the way for performance improvement and innovations in offering services by organizations. On the other hand, knowledge is considered to be a unique asset for any organization, and customers are regarded as a rich source of knowledge for organizations; the knowledge that companies can acquire, analyze and investigate in order to achieve competitive advantage and thereby, take some steps to offer new services, improve their services to customers, respect and fulfill customer satisfaction, discover serious needs and respond to them. Customer knowledge management has become one of the important, determining strategies for businesses, and makes it possible for organizations to carefully identify appeared opportunities in the market and improve their competitive advantage by using marketing tools and sales thoughts and identifying the important factors in attracting customer satisfaction as well as their loyalty. In this research, efforts have been done to investigate the effects of knowledge management in organizations as well as consumer relationship management, and then investigate the role of customer knowledge management in organization development and electronic marketing. In this regard, some strategies for developing and achieving competitive advantage of organizations have been presented.
La musique électroacoustique : analyse morphologique et représentation analytique

L'analyse de la musique electroacoustique est ici developpee sous l'angle de la description morphologique. Celle-ci consiste, apres segmentation du materiau musical, a decrire, a l'aide de criteres, les differentes unites sonores et musicales. Ces criteres sont classees en trois groupes : interne (spectre, dynamique, allure, grain et espace), referentiel (causalite, voix, effet et emotion) et structurel (analyse formelle). La representation graphique est devenue un outil essentiel de l'analyste et peut etre envisagee sous un angle iconique - creer des liens forts entre le son, ses criteres analytiques et les formes graphiques - ou symbolique - figurer le son et ses criteres par un ensemble de symboles extremement precis. En outre, la representation est aussi un materiau ideal pour la publication multimedia : l'analyse representee est associee au son, voire a d'autres medias, pour former un document didactique tres riche. Le plan theorique est complete par des analyses de Spirale de Pierre Henry, " Geologie sonore " de Bernard Parmegiani et Stilleben de Kaija Saariaho.
Apprentissage de la prise en charge de la douleur chez l'enfant : le forum DIACOM et ses modèles sous jacents

DIACOM (Discussions Interactives a bAse de Cas pour la fOrmation Medicale) est un forum interactif qui propose une activite de formation continue, a distance, dediee aux medecins et basee sur le partage et la confrontation de cas cliniques. Sa fonction principale vise a donner la possibilite a des medecins de decrire des cas cliniques et d'inciter la mise en relation de praticiens dont les cas presentent des centres d'interet communs. Cette mise en relation est rendue possible grâce a un processus d'appariement de cas. Cet article vise a presenter les modeles sous-jacents du forum DIACOM, resultant des experimentations menees sur le theme de la prise en charge de la douleur chez l'enfant. Le processus d'appariement elabore grâce a ces experimentations est egalement expose.
Comparative studies in visual pattern processing

Diese Dissertation befasst sich mit empirischer Asthetik, in diesem Fall der Erforschung von visueller Wahrnehmung und Herstellung von abstrakten geometrischen Mustern. Geometrische Muster haben eine hohe Relevanz fur die Asthetikforschung, da Menschen aller Kulturen sie herstellen, um sich und ihre Umgebung zu schmucken. So scheint es naheliegend, dass dieser asthetische Schaffensdrang tief in der menschlichen Psychologie verwurzelt ist. Hinzu kommt, dass abstrakte Muster, die zur Verzierung verwendet werden, weltweit vorzufinden sind, reprasentative Kunst hingegen langst nicht in allen Kulturen vorkommt und dort, wo sie auftritt, die geometrischen Muster nicht ersetzt. Geometrische Muster haben nicht nur eine starke asthetische Dimension, die den menschlichen sense of order (‘Ordnungssinn’), wie es der Kunsthistoriker Ernst Gombrich nannte, widerspiegelt, ihre Strukturen sind auch zu jedem Zeitpunkt des kreativen Prozesses exakt beschreibbar, was eine quantitative Analyse erleichtert. Das zweite Hauptthema dieser Dissertation ist die Rolle der Herstellung in der empirischen Asthetikforschung. Bis auf wenige Ausnahmen lag der Fokus bisher vor allem auf der Wahrnehmung von Kunstwerken, nicht aber auf deren Herstellung. Bereits im 19. Jahrhundert stellte Gustav Fechner drei Methoden vor, um Asthetik zu untersuchen: Methode der Wahl, Methode der Herstellung und Methode der Verwendung. Er empfahl die Kombination von mindestens zwei Methoden bei der Untersuchung eines asthetischen Phanomens. In dieser Arbeit werden alle drei Methoden auf abstrakte geometrische Muster angewendet. Diese Arbeit illustriert das Potenzial, das abstrakte geometrische Muster haben, um unser Verstandnis von wichtigen Teilen des menschlichen asthetischen Drangs oder “Ordnungssinns”, zu erweitern. Visuelle Muster, insbesondere wenn sie mit computerbasierten Methoden eingesetzt werden, stellen ein Mittel der kontrollierten quantitativen Untersuchung des menschlichen kreativen Prozesses dar, die zukunftig eine wichtige Rolle in der empirischen Asthetik einnehmen sollte.
Acute Coronary Syndrome In Elderly - The Difference Compared With Young In Intensive Care Unit Of A Tertiary Hospital In Western Nepal

Introduction: Acute coronary syndrome (ACS), one of the commonest causes of intensive care unit (ICU) admission, casts a large burden of cost on the health care system, along with a huge mortality in the elderly population. Objectives: This study determined the difference in presentation, complication, management and outcome in elderly patients with acute coronary syndrome, as compared to the young patients. Material And Methods: Records of all patients who were diagnosed to have acute coronary syndrome, admitted to the ICU in the Manipal Teaching Hospital in the month of March 2006 to June 2007, was entered in a designated Proforma. Demographic details, clinical findings, treatment and complications were recorded. A total of 153 patients were analyzed and elderly patients (≥ 65 yrs) were compared with young patients (< 65yrs) using SPSS-10.0 software. Results: Elderly patients constituted 51% (78) of the study population, among which 46.2% (36) were females. 7.7% (6) elderly patients presented with atypical symptoms, among which syncope was the commonest. Young patients were more likely to be hypertensive as compared to the elderly patients (70.7% vs. 39.7%; p<0.001). The median time of presentation to the hospital after chest pain was comparable in the two groups: 16 hours overall, but in cases of STEMI, elderly patients were brought to the hospital comparatively late, with a median time of 15 hours (IQ 5.5 – 72 as compared to young individuals in which median time was 7.25 hours (IQ 2.87 – 39 hours), which was statistically significant (p=0.000). Non ST elevated myocardial infarction (NSTEMI) and ST elevated myocardial infarction (STEMI) were similar in distribution among the elderly and young patients. Complication was seen predominantly among the elderly, with 62.8 %( 49) Vs38.7% (29); p =0.03. Overall, heart failure was the commonest complication (28.2%), followed closely by arrhythmias (26.9%). Cardiogenic shock complicating STEMI resulted in high patient mortality in both the age groups. Thrombolysed patients were similar in distribution in both groups. But the success rate of thrombolysis was lower in elderly patients (50%) as compared to young patients (76.9%). Beta blockers were less commonly used in the elderly- 47.4% (34) than in young patients- 61.3% (46). A combination of aspirin and clopidogrel was also less commonly used in the elderly patients {60.3% (47) Vs 76% (57); p=0.03}. Mortality was higher in the elderly patients (24.4% Vs 10.7%; p =0.03) Conclusion: Elderly patients are more prone to complications, have less success rate for thrombolysis and have a higher mortality rate as compared to young patients of ACS.
El triunfo de la justicia poética

Ni el silencio, ni la indiferencia, ni la escritura a contracorriente durante muchos anos consiguieron acallar la voz de uno de los poetas mas hondos y autenticos que ha dado nuestro idioma. Antonio Gamoeda ha sabido mantenersa fiel a la palabra poetica dominante. Su independencia y su opbra son un ejemplo de integridad, de honestidad con la palabra. Quien lea a Antonio Gamoneda puede comprobar que aun queda espacio para la poesia y quien lo lee lo sabe.
"Realistic" Electronic Neuron

An electronic circuit, imitating spiking trains from real neurons, is described. The electronic neuron is a Wien-bridge based circuit with a super-linear spike mechanism. Numerical simulations using ELECTRONICS WORKBENCH and MAT H E M AT I C A software, also hardware experiments have been performed. The characteristics of the spikes are the following: spike height is 100 mV, spike width is 1 ms, and interspike interval is 100 ms.
Hidradenitis supurativa con transformación carcinomatosa Suppurative hidradenitis with carcinomatous transformation

Summary Hidradenitis Suppurativa or Verneuils disease is a chronic inflammatory recurring process that affects the apocrine glands of the armpit, groin, per- ineal area, scalp and anoperineal area. Its accurate ethiology is unknown. It is a rare disease, it is misdiagnosed and its incidence rate is estimated in 1 every 300 adults. It affects mainly women and black race people. However the perianal localization disease affects mainly men. The medical treatment would mitigate the symptoms but most patients have chronic lesions that would require surgical treatment. The squamous cell carcinoma is a rarely reported complication which develops in the chronic lesions of Hidradenitis Suppurativa of long-term evolution. We present a case of a male patient, 51 years old, who has, on old scar lesions, a centrally ulcerated multilobulated tumor formation of 3 months of evolution localized in the left gluteo-perineal area. Complementary methods were used which led to the diagnostics of Hydradernitis Suppurativa with Carcinomatose Transformation (Squamous cell carcinoma). Surgical treatment followed by skin graft was used with excellent evolution. The reason for this presentation is the infrequent localization and the unusual complication. Something important to point out is that publications on this topic are rare.
Correcciones a la entropía de entrelazado y la constante de Newton.

La entropia de entrelazado es una magnitud relevante en diversas areas de la fisica, que ha sido relacionada con varias magnitudes de la teoria de campos. En este trabajo proponemos una formula para el termino de area de la entropia de entrelazado de un campo cuantico arbitrario en terminos de correadores de la traza del tensor de energia impulso. Esta igualdad es sugerida por la formula de Bekenstein-Hawking que relaciona la entropia de un agujero negro con el area del horizonte de eventos y la constante de Newton. En el caso de la entropia de entrelazado, existe una relacion similar entre el termino de area de la misma y la correccion ΔG"-1 a la constante de Newton que hace un campo cuantico. Para calcular ΔG"-1, derivamos una generalizacion a toda dimension de una formula debida a Adler, lo que nos permite establecer la igualdad que proponemos en cualquier dimension. Comprobamos por calculos explcitos que la igualdad se cumple para los campos libres escalar y fermionico en todas las dimensiones.
SEX PREFERENCESAMONG RURAL COMMUNITY: PUBLIC HEALTH AND SOCIAL CONCERN

Background: Sex preference is choice of selecting the sex of children by their parents or family members. The objective of the study was to study the existence of sex preference among rural community. Material and methods: A Cross-sectional study was carried out among 200 ever married women of reproductive age group. Random digits sampling method was used to select 10 villages in Rahata Tehsil of Ahmednagar, while systematic sampling was applied for selection of 20 samples in each village. Results: In the previous sex preference for male child was 37.3%, 58.75%, 88.5%, 100% and 100% from firstchild to fifth respectively, while female preference and either sexpreference was decreasing. In the current sex preference for male, female and either was 36.8%, 25% and 38.2% respectively. Future sex preference was 40.9% for male child, 22.7% for female child and 36.4% for either sex. The main reason for son preference was for old age care and support, to continue the family name and earning member in the family. Conclusion: Study confirms that son preference still existsin the rural community of Maharashtra. Attitude for son preference is mainly because of the economic earning, old age care and continuation of the family nameamong all groups.
Traditional Medicine Programmes in Madagascar

The note reviews Madagascar's inherited wealth of ethno-medical knowledge, being endowed with a flora of unique global importance on account of its biodiversity, endemicity, and ethno-medical uses. The government of Madagascar has shown its political commitment to traditional medicine by supporting, through an inter-ministerial convention, a commission to study regulations on traditional medicine, and its pharmacopoeia in the country, which was established in May 1996. The note further enumerates the general and operational objectives of the traditional medicine policy, and identifies associations and institutions involved in traditional medicine, in medicinal plant research and production, in pharmacopoeia, and in phyto-medicine production, and relevant programmes.