Miracle-dz/UniFAR-FTUs huggingface dataset:
Video Head Impulse Test in Labyrinthine Fistula due to Middle Ear Cholesteatoma.

OBJECTIVES To assess and monitor lateral semicircular canal (LSC) function over time in patients affected by chronic otitis media with cholesteatoma (CHO) complicated by fistula of LSC (LSC-F) before and after surgery using video Head Impulse Test (vHIT). MATERIALS AND METHODS Eight patients aged 18-67 years affected by CHO with imaging-ascertained LSC-F were included in this preliminary prospective study. The following protocol has been applied: oto-microscopic diagnosis with patient's history; computed tomography scan of the temporal bone; surgery with concomitant resurfacing of LSF-F; audiological and vestibular evaluation before surgery (T0) and at 30 days (T1), 6 months (T2), and 1 year after surgery (T3). vHIT was used to assess vestibulo-ocular reflex (VOR) in LSC. RESULTS None of the patients showed deterioration of bone conduction hearing levels during the different time of evaluation. Three patients showed a reduced VOR gain and catch-up saccades at T0, with VOR gain normalization at T2. This finding remained stable at the 1-year follow-up. The VOR gain in the nonaffected side generally experienced an increase, paralleled by the normalization on the affected side, with statistically significant correlation. The subjects with normal vHIT before surgery did not show any variation following surgery. CONCLUSION vHIT allows the assessment of LSC function in case of fistula. The adopted surgical fistula repair did not induce deterioration of the auditory or LSC function, but indeed, it could prevent worsening and help promoting recovery to the normal function.
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor

Overexpression of P-glycoprotein (P-gp) and other ATP-binding cassette (ABC) transporters in multidrug resistant (MDR) cancer cells is responsible for the reduction of intracellular drug accumulation, thus decreasing the efficacy of chemotherapeutics. P-gp is also found at endothelial cells’ membrane of the blood-brain barrier, where it limits drug delivery to central nervous system (CNS) tumors. We have previously developed a set of pyrazolo[3,4-d]pyrimidines and their prodrugs as novel Src tyrosine kinase inhibitors (TKIs), showing a significant activity against CNS tumors in in vivo. Here we investigated the interaction of the most promising pair of drug/prodrug with P-gp at the cellular level. The tested compounds were found to increase the intracellular accumulation of Rho 123, and to enhance the efficacy of paclitaxel in P-gp overexpressing cells. Encouraging pharmacokinetics properties and tolerability in vivo were also observed. Our findings revealed a novel role of pyrazolo[3,4-d]pyrimidines which may be useful for developing a new effective therapy in MDR cancer treatment, particularly against glioblastoma.
Haptic Feedback Perception and Learning With Cable-Driven Guidance in Exosuit Teleoperation of a Simulated Drone

Robotics teleoperation enables human operators to control the movements of distally located robots. The development of new wearable interfaces as alternatives to hand-held controllers has created new modalities of control, which are more intuitive to use. Nevertheless, such interfaces also require a period of adjustment before operators can carry out their tasks proficiently. In several fields of human-machine interaction, haptic guidance has proven to be an effective training tool for enhancing user performance. This paper presents the results of psychophysical and motor learning studies that were carried out with human participant to assess the effect of cable-driven haptic guidance for a task involving aerial robotic teleoperation. The guidance system was integrated into an exosuit, called the Flyjacket, that was developed to control drones with torso movements. Results for the just noticeable difference and from the Stevens Power Law suggest that the perception of force on the users’ torso scales linearly with the amplitude of the force exerted through the cables and the perceived force is close to the magnitude of the stimulus. Motor learning studies reveal that this form of haptic guidance improves user performance in training, but this improvement is not retained when participants are evaluated without guidance.
Learning through observing: Effects of modeling truth- and lie-telling on children's honesty.

The current study examined the influence of observing another's lie- or truth-telling - and its consequences - on children's own honesty about a transgression. Children (N = 224, 5 to 8 years of age) observed an experimenter (E) tell the truth or lie about a minor transgression in one of five conditions: (1) Truth-Positive - E told the truth with a positive outcome; (2) Truth-Negative - E told the truth with a negative outcome; (3) Lie-Positive - E lied with a positive outcome; (4) Lie-Negative - E lied with a negative outcome; (5) Control - E did not tell a lie or tell the truth. Later, to examine children's truth or lie-telling behavior, children participated in a temptation resistance paradigm (TRP) where they were told not peek at a trivia question answer. They either peeked or not, and subsequently lied or told the truth about that behavior. Additionally, children were asked to give moral evaluations of different truth and lie-telling vignettes. Overall, 85% of children lied. Children were less likely to lie about their own transgression in the TRP when they had previously witnessed the experimenter tell the truth with a positive outcome or tell a lie with a negative outcome. This article is protected by copyright. All rights reserved.
Associations between change in blood pressure and functional outcome, early events and death: results from the Efficacy of Nitric Oxide in Stroke trial

Objectives: High blood pressure (BP) is associated with a poor outcome after acute stroke. Early reduction in BP may be associated with fewer early adverse events and deaths, and improved functional outcome. Methods: Analyses used data from the Efficacy of Nitric Oxide in Stroke trial, a multicentre randomized single-masked and outcome-masked trial of glyceryl trinitrate vs. no glyceryl trinitrate in 4011 patients recruited within 48 h of an ischaemic or haemorrhagic stroke and with raised SBP (140–220 mmHg). Change in SBP from baseline to day 1 was categorized as: more than 15% decrease, 15–5% decrease, 5% decrease to 5% increase (no change – reference) and more than 5% increase. The primary outcome was functional outcome (modified Rankin scale) score at 90 days. Results: Across all patients, both moderate (5–15%) and large (>15%) decreases in SBP were associated with beneficial shifts in the modified Rankin scale relative to patients with no change in BP: adjusted common odds ratio (OR) 0.81 [95% confidence interval (CI) 0.70–0.90] and OR 0.84 (95% CI 0.71–1.00), respectively. A moderate decrease in SBP was also associated with a lower risk of early adverse events, adjusted OR 0.69 (95% CI 0.52–0.90). Conclusion: Modest decreases in SBP in acute stroke appear to be associated with fewer early events and better long-term functional outcome.
Cytomegalovirus (CMV) infection and risk of mortality in allogeneic hematopoietic stem cell transplantation (Allo‐HSCT): A systematic review, meta‐analysis, and meta‐regression analysis

Controversy surrounds the potential association between cytomegalovirus (CMV) infection and increased risk of mortality after allogeneic hematopoietic stem cell transplantation (Allo‐HSCT). A systematic literature search was conducted using the PubMed, EMBASE, and Web of Science databases, assessing the association between CMV infection, as documented by the pp65 antigenemia assay or by polymerase chain reaction (PCR) using blood specimens, and overall mortality (OM) and nonrelapse mortality (NRM) in the allo‐HSCT setting. Pooled effects were estimated using the generic inverse variance random effects model. Heterogeneity was evaluated by Cochrane's Q test and I2 statistics. The source of heterogeneity was investigated by meta‐regression and subgroup analyses. Twenty‐six of 1367 studies fulfilled eligibility criteria. CMV infection identified by PCR monitoring was significantly associated with an increased risk of OM and NRM (hazard ratio 1.47, 95% confidence interval [1.20‐1.81], P ≤ .001; hazard ratio 1.68, 95% confidence interval [1.14‐2.49], P = .05, respectively). In this setting, the use of preemptive antiviral therapy (PET) resulted in a twofold increased risk of OM and NRM. The estimated effect sizes were associated with allo‐HSCT modalities. Although our analyses point to an association between CMV infection and an increased risk of OM and NRM in allo‐HSCT recipients, the high heterogeneity across studies prevented drawing of robust conclusions on this matter.
Magnesium for Dynamic Nanoplasmonics

Conspectus The key component of nanoplasmonics is metals. For a long time, gold and silver have been the metals of choice for constructing plasmonic nanodevices because of their excellent optical properties. However, these metals possess a common characteristic, i.e., their optical responses are static. The past decade has been witnessed tremendous interest in dynamic control of the optical properties of plasmonic nanostructures. To enable dynamic functionality, several approaches have been proposed and implemented. For instance, plasmonic nanostructures can be fabricated on stretchable substrates or on programmable templates so that the interactions between the constituent metal nanoparticles and therefore the optical responses of the plasmonic systems can be dynamically changed. Also, plasmonic nanostructures can be embedded in tunable dielectric materials, taking advantage of the sensitive dependence of the localized surface plasmon resonances on the neighboring environment. Another approach, which is probably the most intriguing one, is to directly regulate the carrier densities and dielectric functions of the metals themselves. In this Account, we discuss a relatively new metal in nanoplasmonics, magnesium, and its important role in the development of dynamic plasmonic nanodevices at visible frequencies. We first elucidate the basic optical properties of Mg and compare it with conventional plasmonic materials such as Au, Ag, and others. Then we describe a unique characteristic of Mg, i.e., its reversible phase transitions between the metallic state and a dielectric state, magnesium hydride, through hydrogenation and dehydrogenation. This sets the basis for Mg in dynamic nanoplasmonics. In particular, the structural properties and dielectric functions of the two distinct states are discussed in detail. Subsequently, we highlight the experimental investigations of the physical mechanisms and nanoscale understanding of Mg nanoparticles during hydrogenation and dehydrogenation. We then introduce a plethora of newly developed Mg-based dynamic optical nanodevices for applications in plasmonic chirality switching, dynamic color displays with Mg nanoparticles and films, and dynamic metasurfaces for ultrathin and flat optical elements. We also outline strategies to enhance the stability, reversibility, and durability of Mg-based nanodevices. Finally, we end this Account by outlining the remaining challenges, possible solutions, and promising applications in the field of Mg-based dynamic nanoplasmonics. We envision that Mg-based dynamic nanoplasmonics will not only provide insights into understanding the catalytic processes of hydrogen diffusion in metals by optical means but also will open an avenue toward functional plasmonic nanodevices with tailored optical properties for real-world applications.
Bridging the Reciprocal Gap between Sleep and Fruit and Vegetable Consumption: A Review of the Evidence, Potential Mechanisms, Implications, and Directions for Future Work

A substantial burden of disease and mortality globally is attributable to both sleep disruption and low intakes of fruit and vegetable (FV) and there is increasing mechanistic and epidemiological evidence to support a reciprocal relationship between the two. This review provides an overview of experimental and observational studies assessing the relations between sleep and FV consumption from 52 human adult studies. Experimental studies are currently limited and show inconsistent results. Observational studies support a non-linear association with adults sleeping the recommended 7–9 hours/day having the highest intakes of FV. The potential mechanisms linking sleep and FV consumption are highlighted. Disrupted sleep influences FV consumption through homeostatic and non-homeostatic mechanisms. Conversely, FV consumption may influence sleep through polyphenol content via several potential pathways. Few human experimental studies have examined the effects of FV items and their polyphenols on sleep and there is a need for more studies to address this. An appreciation of the relationship between sleep and FV consumption may help optimize sleep and FV consumption and may reduce the burden of chronic diseases. This review provides implications for public health and directions for future work.
Amelioration of Behavioral Impairments and Neuropathology by Antiepileptic Drug Topiramate in a Transgenic Alzheimer’s Disease Model Mice, APP/PS1

Alzheimer’s disease (AD) is a neurodegenerative disease that is the main cause of dementia in the elderly. The aggregation of β-amyloid peptides is one of the characterizing pathological changes of AD. Topiramate is an antiepileptic drug, which in addition, is used in the treatment of many neuropsychiatric disorders. In this study, the therapeutic effects of topiramate were investigated in a transgenic mouse model of cerebral amyloidosis (APP/PS1 mice). Before, during, and after topiramate treatment, behavioral tests were performed. Following a treatment period of 21 days, topiramate significantly ameliorated deficits in nest-constructing capability as well as in social interaction. Thereafter, brain sections of mice were analyzed, and a significant attenuation of microglial activation as well as β-amyloid deposition was observed in sections from topiramate-treated APP/PS1 mice. Therefore, topiramate could be considered as a promising drug in the treatment of human AD.
MODELO CONCEPTUAL PARA MODELACIÓN DE APLICACIONES MÓVILES SENSIBLES AL CONTEXTO / CONCEPTUAL MODEL FOR CONTEXT-AWARE MOBILE APPLICATIONS

Las aplicaciones moviles sensibles al contexto presentan caracteristicas propias que afectan el proceso de desarrollo del software. Estas deben ejecutarse en diferentes plataformas de computacion, ajustarse a las capacidades de diversos dispositivos de acceso y adaptarse a diferentes contextos de uso. El contexto de uso facilita la utilizacion del ambiente en una forma que garantice la calidad del servicio al usuario. Esto es un aspecto determinante en aplicaciones moviles, generalmente inalambricas, cuyas propiedades imponen como determinante la gestion de la calidad de estos servicios. La meta de este trabajo es definir un modelo de calidad para el dominio de aplicaciones moviles sensibles al contexto. La importancia de este modelo es la especificacion de los requisitos de calidad para el producto final del software y este tambien puede ser usado para una evaluacion cuantitativa de todos los productos de software durante el proceso de desarrollo. El nivel de servicio requerido se especifica de acuerdo a un modelo de calidad. Este modelo se define utilizando una taxonomia denominada RECLAMO (Requirements Classification Model) y el nuevo estandar ISO/IEC 25030 es usado para identificar los requerimientos de calidad y el ISO 25010 es usado para especificar un modelo de calidad. ABSTRACT Context-aware mobile applications show special features that can affect the software development process. These systems must run on heterogeneous computing platforms, must adjust to the capacities of different access devices and adapt to different contexts of use. The quality of service to the user is guaranteed by the way the environment is responding, which is facilitated by the context of use. This aspect is crucial in mobile applications, often wireless, demanding the quality of these services. The required service level is specified by a quality model. The goal of this work is to define the quality model for the context-aware mobile applications domain. The importance of this model is the specification of the quality requirements for the final software product and it can be used for a quantitative evaluation of all the software products obtained during the development process. A taxonomy called RECLAMO (Requirements Classification Model) and the new standard ISO/IEC 25030 is used to identify the quality requirements and the ISO 25010 is used to specify quality model.Keywords: Context-aware applications, Quality model, RECLAMO, ISO/IEC 25010, ISO/IEC 25030.
Estimating glomerular filtration rate in adult kidney transplant recipients in the Asian population

Estimation of glomerular filtration rate (GFR) in renal transplant patients is often assessed by application of creatinine-based equations. The aim was to correlate the estimated GFR (eGFR) using creatinine-based equations [Cockroft-Gault, Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Nankivell] with gold standard 51Cr-EDTA in kidney transplant patients in the Asian population. This is a single-center, cross-sectional study involving adult renal transplant patients. Background demographic data, medications, office blood pressure, and baseline investigations were taken. Correlations between measured GFR and eGFR were analyzed and Pearson’s correlation coefficients, bias, and accuracy were assessed. Thirty-seven renal transplant patients with a mean age of 46 ± 13 years were recruited. Majority were Chinese (68%), Malay (24%), and Indian (8%). The median duration of the transplant was 84 (interquartile range 60,132) months. The mean measured GFR was 71 ± 21 mL/min/1.73 m2. Cockroft-Gault and CKD-EPI has the best correlation with 51Cr-EDTA with Pearson correlation coefficients of 0.733 (P <0.001) and 0.711 (P < 0.001), respectively. All formulae showed >80% accuracy with eGFR lies between 30% of the measured value. CKD-EPI and MDRD had the greatest accuracy with 89.2% each. Clinician may use any of these three serum creatinine-based equations to estimate GFR in kidney transplant recipients.
The Potential Associations of Pornography Use with Sexual Dysfunctions: An Integrative Literature Review of Observational Studies

This paper reviews the associations between pornography use and sexual dysfunction based on evidence from observational studies. The existing data in this regard mostly derive from cross-sectional investigations and case reports. There is little if no evidence that pornography use may induce delayed ejaculation and erectile dysfunction, although longitudinal studies that control for confounding variables are required for a full assessment. The associations between pornography use and sexual desire may differ between women and men although the existing data is contradictory and causal relationships cannot be established. The strongest evidence is available for the relation of pornography use with decreased sexual satisfaction, although the results of prospective studies are inconsistent. The paper outlines future research prospects beneficial in understanding the nature of associations between pornography use and sexual dysfunctions in men and women.
Reproducibility of the European Society of Hypertension - International Protocol for validation of blood pressure measuring devices in obese patients.

BACKGROUND Electronic devices for blood pressure (BP) measurements need to go through independent clinical validation as recommended by different authorities, both in general and special populations. Reproducibility of such validation protocols is unknown. OBJECTIVE The aim of this study was to assess the inter-centre reproducibility of the European Society of Hypertension-International protocol (ESH-IP) in patients with large arm circumference at least 32 cm or obesity. METHODS Two independent validation studies were performed in parallel according to the ESH-IP protocol in two centres (Serbia and Armenia). The two studies were performed blindly and independently. The ESH-IP criteria were applied for the analysis. The OMRON RS7 wrist oscillometric devices were used in both studies. RESULTS The distribution of the mean differences values of 5 or less, 10 or less and 15 mmHg or less between the observers and the device were for the Serbia team: 74, 95 and 98 for SBP and 78, 95 and 99 for DBP; and for the Armenia team: 86, 95 and 99 for SBP and 90, 99 and 99 for DBP. The mean differences (SD) of BP values between the observers and the device were for the Serbia team of 1.7 ± 4.8 mmHg for SBP and 1.2 ± 4.6 mmHg for DBP and for the Armenia team of -1.1 ± 4.2 mmHg for SBP and -0.3 ± 3.5 mmHg for DBP. CONCLUSION This study showed that the ESH-IP validation protocol presents a good inter-centre reproducibility. The OMRON RS7 device showed similar results, fulfilling the validation criteria in two independent studies in patients with arm circumference at least 32 cm.
Satellite-based assessment of electricity restoration efforts in Puerto Rico after Hurricane Maria

A real-time understanding of the distribution and duration of power outages after a major disaster is a precursor to minimizing their harmful consequences. Here, we develop an approach for using daily satellite nighttime lights data to create spatially disaggregated power outage estimates, tracking electricity restoration efforts after disasters strike. In contrast to existing utility data, these estimates are independent, open, and publicly-available, consistently measured across regions that may be serviced by several different power companies, and inclusive of distributed power supply (off-grid systems). We apply the methodology in Puerto Rico following Hurricane Maria, which caused the longest blackout in US history. Within all of the island’s settlements, we track outages and recovery times, and link these measures to census-based demographic characteristics of residents. Our results show an 80% decrease in lights, in total, immediately after Hurricane Maria. During the recovery, a disproportionate share of long-duration power failures (> 120 days) occurred in rural municipalities (41% of rural municipalities vs. 29% of urban municipalities), and in the northern and eastern districts. Unexpectedly, we also identify large disparities in electricity recovery between neighborhoods within the same urban area, based primarily on the density of housing. For many urban areas, poor residents, the most vulnerable to increased mortality and morbidity risks from power losses, shouldered the longest outages because they lived in less dense, detached housing where electricity restoration lagged. The approach developed in this study demonstrates the potential of satellite-based estimates of power recovery to improve the real-time monitoring of disaster impacts, globally, at a spatial resolution that is actionable for the disaster response community.