Miracle-dz/UniFAR-FTUs huggingface dataset:
ake the monkey and run imberley

Background: The common marmoset (Callithrix jacchus) is a small, New World primate that is used extensively in biomedical and behavioral research. This short-lived primate, with its small body size, ease of handling, and docile temperament, has emerged as a valuable model for aging and neurodegenerative research. A growing body of research has indicated exercise, aerobic exercise especially, imparts beneficial effects to normal aging. Understanding the mechanisms underlying these positive effects of exercise, and the degree to which exercise has neurotherapeutic effects, is an important research focus. Thus, developing techniques to engage marmosets in aerobic exercise would have great advantages. New method: Here we describe the marmoset exercise ball (MEB) paradigm: a safe (for both experimenter and subjects), novel and effective means to engage marmosets in aerobic exercise. We trained young adult male marmosets to run on treadmills for 30 min a day, 3 days a week. Results: Our training procedures allowed us to engage male marmosets in this aerobic exercise within 4 weeks, and subjects maintained this frequency of exercise for 3 months. Comparison with existing methods: To our knowledge, this is the first described method to engage marmosets in aerobic exercise. A major advantage of this exercise paradigm is that while it was technically forced exercise, it did not appear to induce stress in the marmosets. Conclusions: These techniques should be useful to researchers wishing to address physiological responses of exercise in a marmoset model. © 2015 Elsevier B.V. All rights reserved.
The Characteristics of the Swedish/Norwegian El-Certificate Market: An empirical impulse-response analysis

In the recent years the increasing threat of climate change has become a political issue all around the world. Looking for ways to minimize climate change has led to ideas of using renewable production of electricity instead of coal, oil and gas. In Sweden and Norway, the El-Certificate Scheme was introduced as a way to achieve a higher production of renewable energy, and with that achieve a lower amount of carbon emissions. This thesis analyses the conditional mean and volatility characteristics of the Spot and One-year forward price of the Swedish-Norwegian El-Certificate market (2005-2018). Based on statistical tests of the two weekly price movement series, a semi-nonparametric (SNP) model is used for a wellspecified conditional mean and volatility. Moreover, from relatively new available model specification software, an impulse-response analysis is applied for extracting enhanced market characteristics. The market for Spot and One-Year Forward prices show similar results. Hence, for the impulse-response analysis both series show linear and asymmetric mean reversion. For both series, the responses are therefore greater for negative impulses. For the volatility of both series, the impulse-response analysis shows an increase in variance when the impulses increase, together with larger responses for negative impulses. The impulse response is short, with a large standard derivation, indicating high uncertainty. The analysis shows large manifestations in the negative direction has a longer mean reversion time, the volatility is larger with a negative change.
Role of clover species and AM Fungi (Glomus mosseae) on forage yield, nutrients uptake, nitrogenase activit y and soil microbial biomass

The effects of earthworms (Ew), arbuscular mycorrhi zal (AM) fungi and mixed cropping systems on nitrogenase activity of rhizosphere free -living bacteria, soil microbial biomass C (MBC) and growth of clovers were studied in various mixed cropping ratios of 1:0, 3:1, 1:1 and 1:3 berseem clover ( Trifolium alexandrinum L.) to Persian clover ( Trifolium resupinatum L.). AMF G. mosseae and cropping system gave significantly affected on total forage yield. Mixed cropping gave a greater stability of yield over mon oculture. Although G. mosseae application increased mycorrhiza colonization rate but there wa s no obvious effect of clover ratios on mycorrhiza colonization rate. The greatest P-uptake was in the berseem clover:Persian clover ration treatment of 3:1. N-uptake accumulated in ab ove-ground biomass of 173.64 kg ha -1
Multiwavelength modelling of the β Leo debris disc: one, two or three planetesimal populations?

In this paper we present a model of the β Leo debris disc, with an emphasis on modelling the resolved Photodetector Array Camera and Spectrometer (PACS) images obtained as a part of the Herschel key programme DEBRIS. We also present new Spectral and Photometric Imaging REceiver (SPIRE) images of the disc at 250 μm, as well as new constraints on the disc from SCUBA-2, mid-infrared (mid-IR) and scattered light imaging. Combining all the available observational constraints, we find three possible models for the β Leo (HD 102647) debris disc: (i) a two-component model, comprised of a hot component at 2 au and a cold component from 15 to 70 au; (ii) a three-component model with hot dust at 2 au, warm dust at 9 au and a cold component from 30 to 70 au, is equally valid since the cold emission is not resolved within 30 au; (iii) a somewhat less likely possibility is that the system consists of a single very eccentric planetesimal population, with pericentres at 2 au and apocentres at 65 au. Thus, despite the wealth of observational constraints significant ambiguities remain; deep mid-IR and scattered light imaging of the dust distribution within 30 au seems to be the most promising method to resolve the degeneracy. We discuss the implications for the possible planetary system architecture, e.g. the two-component model suggests that planets may exist at 2–15 au, while the three-component model suggests planets between 2 and 30 au with a stable region containing the dust belt at 9 au, and there should be no planets between 2 and 65 au in the eccentric planetesimal model. We suggest that the hot dust may originate in the disintegration of comets scattered in the cold disc, and examine all A stars known to harbour both hot and cold dust to consider the possibility that the ratio of hot and cold dust luminosities is indicative of the intervening planetary system architecture.
Pseudomonas aeruginosa and Staphylococcus aureus-defensins against antibiotic-resistant θ-and α Microbicidal effects of

Antibiotic-resistant bacterial pathogens threaten public health. Because many antibiotics target specific bacterial enzymes or reactions, corresponding genes may mutate under selection and lead to antibiotic resistance. Accordingly, antimicrobials that selectively target overall microbial cell integrity may offer alternative approaches to therapeutic design. Naturally occurring mammalian aand y-defensins are potent, non-toxic microbicides that may be useful for treating infections by antibiotic-resistant pathogens because certain defensin peptides disrupt bacterial, but not mammalian, cell membranes. To test this concept, clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), including vancomycin heteroresistant strains, and ciprofloxacin-resistant Pseudomonas aeruginosa (Cip-PA) were tested for sensitivity to a-defensins Crp-4, RMAD-4 and HNPs 1-3, and to RTD-1, macaque y-defensin-1. In vitro, 3 lM Crp-4, RMAD-4 and RTD-1 reduced MRSA cell survival by 99%, regardless of vancomycin susceptibility. For PA clinical isolates that differ in fluoroquinolone resistance and virulence phenotype, peptide efficacy was independent of strain ciprofloxacin resistance, site of isolation or virulence factor expression. Thus, Crp-4, RMAD-4 and RTD-1 are effective in vitro antimicrobials against clinical isolates of MRSA and Cip-PA, perhaps providing templates for development of aand y-defensin-based microbicides against antibiotic resistant or virulent infectious agents.
Birds, resources and time in a tablelands forest

In forests on the Southern Tablelands of New South Wales seasonal events within the avian community were tied to the annual cycle of cold winters and warm summers. Insect, carbohydrate and seed abundance changed with the seasons and were tracked by the avifauna. Superimposed were events determined on a larger regional scale. Irruptions of birds from the arid interior and drought caused significant, if transitory, changes in the forest avifauna. This has implications for the conservation and management of forest ecosystems.
Microimmune Algorithm for Solving Inverse Kinematics of Redundant Robots

A micro immune optimization algorithm presented in this paper was considered for solving inverse kinematics of a redundant robotic arm. For this purpose, a multiobjective criterion was defined to compare performances of micro immune and micro genetic algorithms. Multiobjective optimization was used to determine a set of best algorithms, and the micro immune algorithm proved superior in solving a selected optimization problem. The assessment of time needed for algorithms to solve the inverse kinematics problem on-line was made based on the tests carried out on a low-cost micro controller.
ise au point uivi clinique et paraclinique après radiothérapie pour un cancer des oies aérodigestives supérieures linical and paraclinical follow-up after radiotherapy for head and neck cancer

Head and neck cancer management often involves heavy multimodal treatments including radiotherapy. Despite the improvement of intensity-modulated radiation therapy, acute and late toxicities remain important. After such treatment, patients have to face different potential problems, depending on the post-therapeutic delay. In this way, short-term follow-up permits to appreciate the healing of acute toxicities and response to treatment. Long-term follow-up aims to recognize second primitive tumours and distant failure, and to detect and manage late toxicities. Medical and psychosocial supportive cares are essential, even after several years of complete remission. The objective of this article is to review the modalities of short-term and long-term follow-up of patients who receive a radiotherapy for head and neck cancer. © 2015 Société française de radiothérapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.
Aalborg Universitet Cooperative Control with Virtual Selective Harmonic Capacitance for Harmonic Voltage Compensation in Islanded

This paper focuses on the islanded operation of microgrids. In this mode of operation, the microsources are required to cooperate autonomously to regulate the local grid voltage and frequency. Droop control is typically used to achieve this autonomous voltage and frequency regulation. Inverters having LCL output filters would cause voltage distortion to be present at the PCC when non-linear current is supplied to the load due to the voltage drop across the grid side inductor. Techniques to reduce the output voltage distortion typically consist of installing either passive or active filters to selectively compensate harmonic frequencies. However, by adding suitable control strategies to the inverters connected to the microgrid, the power quality of the microgrid can be improved without the installation of any additional equipment. In this paper, a capacitive virtual impedance loop, implemented in each of the microsource inverters, is proposed so as to dampen the voltage harmonics at the PCC. Simulation results are presented showing the suitability of the proposed algorithm in dampening the PCC voltage harmonics.
Septins in filamentous fungi Gladfelter 721 A primer on basic properties of septin proteins

Recent investigations have established core principles by which septins can form non-polar filaments in vitro. How cells then assemble, regulate and use septin polymers is still only beginning to be understood. It is clear that there is plasticity and variability in septin organization across diverse species and cell types. Work in the filamentous fungi has been invaluable in discovering this variation in form and function. In particular filamentous fungi display many forms of higher order septin structures and study of septins in these systems has led to insights into septin assembly, dynamics and regulation. Importantly in many cases work in these alternative systems reveal differences to how septins may be organized, functioning or regulated in Saccharomyces cerevisiae. Here I review the novel aspects of septin biology found in filamentous fungi and raise many open questions about these enigmatic polymers that should guide future study.
European Conference on Information Systems ( ECIS ) 5-15-2012 INTEGRATION : AN OMITTED VARIABLE IN INFORMATION SYSTEMS RESEARCH

The widespread deployment of IT in the past decades has significantly increased the integration reach, breadth, and scope in organisations. Many of the associated socio-economic phenomena have been studied by IS researchers, for example, in the context of IT adoption, the business value of IT, and IS success. Surprisingly though, the concept of integration in itself has so far attracted only little interest on the part of researchers. According to our knowledge, no established theoretical framework seems to place integration-related constructs at the centre of scientific inquiry. The objective of the present study is to take a first step to fill this gap by reviewing the literature on integration in order to structure the existing body of knowledge and to derive an agenda for further research in this area. Our literature review reveals that, in spite of its importance for academia and practice, integration is still an under-researched topic, with a noticeable lack of theorization and synthesis of the different research strands into a more holistic model. As we argue, a to-be-developed ‘Theory of Integration’ would be highly valuable to increase our understanding of the different phenomena surrounding integration on the technological and the organisational level within the firm.
Proposing a General Feature Weighting Function

Feature weighting is a vital step in machine learning tasks that is used to approximate the optimal degree of influence of individual features. Because the salience of a feature can be changed by different queries, the majority of existing methods are not sensitive enough to describe the effectiveness of features. We suggest dynamic weights, which are dynamically sensitive to the effectiveness of features. In order to achieve this, we propose a differentiable feature weighting function that dynamically assigns proper weights for each feature, based on the distinct feature values of the query and the instance. The proposed weighting function, which is an extension of our previous work, is suitable for both single-modal and multi-modal weighting problems, and, hence, is referred to as a General Weighting Function. The number of parameters of the proposed weighting function is fewer compared to the ordinary weighting methods. To show the performance of the General Weighting Function, we proposed a classification algorithm based on the notion of dynamic weights, which is optimized for one nearest neighbor algorithm. The experimental results show that the proposed method outperforms the ordinary feature weighting methods.
Investigation of the conductive behavior of poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonic acid) for organic electronics

xvi CHAPTER 1 INTRODUCTION . 1 1.1. Conducting Polymers . 2 1.2. Poly(3,4-ethylenedioxythiophene/poly(styrene sulfonic acid) (PEDOT/PSS) . 4 1.3. PEDOT synthesis . 6 1.4. Modification of PEDOT/PSS . 11 1.5. PEDOT/PSS applications . 13 1.6. Objectives. 15 CHAPTER 2 EXPERIMENTAL . 17 2.1. Materials and Reagents . 18 2.2. Preparation of PEDOT/PSS aqueous dispersions . 19 2.3. Preparation of end-capped PEDOT/PSS aqueous dispersions . 20 2.4. Synthesis of Star PEDOT/PSS . 22 2.5. Preparation of PEDOT/PSS films . 24 2.6. Conductivity measurements . 24 2.7. Capillary electrophoresis . 25 2.8. FTIR studies . 27 2.9. NMR studies . 27 2.10. UV spectrophotometric analysis . 27 2.11. Particle size measurements . 27 2.12. Zeta potential measurements . 28 2.13. Thermogravimetric analysis . 28 2.14. Optical microscopy and Scanning Electron Microscopy (SEM) . 29 2.15. Statistical Analysis using SPSS program . 29
Genetic variation in PNPLA 3 confers susceptibility to nonalcoholic fatty liver disease

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, Boerwinkle E, Cohen JC, Hobbs HH. Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem of unknown etiology that varies in prevalence among ancestry groups. To identify genetic variants contributing to differences in hepatic fat content, we carried out a genome-wide association scan of nonsynonymous sequence variations (n = 9229) in a population comprising Hispanic, African American and European American individuals. An allele in PNPLA3 (rs738409[G], encoding I148M) was strongly associated with increased hepatic fat levels (P = 5.9 10( 10)) and with hepatic inflammation (P = 3.7 10( 4)). The allele was most common in Hispanics, the group most susceptible to NAFLD; hepatic fat content was more than twofold higher in PNPLA3 rs738409[G] homozygotes than in noncarriers. Resequencing revealed another allele of PNPLA3 (rs6006460[T], encoding S453I) that was associated with lower hepatic fat content in African Americans, the group at lowest risk of NAFLD. Thus, variation in PNPLA3 contributes to ancestry-related and inter-individual differences in hepatic fat content and susceptibility to NAFLD.
The mat dist

Material and methods. Three-dimensional models of teeth were created with the ANSYS program to simulate the different materials used for metal ceramic crowns (nickel-chromium, gold-palladium), posts and cores (Ti, Ni-Cr, Au-Pd), and cement (glass ionomer, composite resin, zinc phosphate, polycarboxylate, Panavia). Models were divided into 2 groups according to the alloys used in the crown restorations. A simulated masticatory force of 400 N was applied to the occlusal surface at a 45-degree inclination in the linguolabial direction to the long axis of the tooth, and von Mises equivalent stress values were calculated.
Vacuoles Play a Decisive Role in Calcium Homeostasis in Neurospora crassa

SUMMARY: Mutants of the filamentous fungus Neurospora crassa which grow well only in a medium in which the concentration of calcium is lower than in the medium used for culture of the wild-type strain were isolated by use of the ionophore A23187 and medium which contained a high concentration of calcium. These mutants showed a significantly lower uptake of calcium into their vacuoles than the wild-type, while other activities associated with the transport of calcium across several other types of membrane were not affected. The results indicated an essential role for the vacuoles in the regulation of the cytosolic concentration of calcium.
THE MORPHOLOGY AND RELATIONSHIPS OF DALECHAMPIA SCANDENS (EUPHORBIACEAE)

A B S T R A C T The circumtropical but preponderantly American genus Dalechampia, comprising nearly 100 species of twining vines (or rarely subshrubs), is strikingly isolated within the Euphorbiaceae because of its distinctive bibracteate inflorescences. There has been considerable taxonomic controversy with regard to the relationships of the genus, and it has been suggested that Dalechampia is allied to the tribe Euphorbieae because of a supposed analogy between its inflorescence and the cyathium in the Euphorbieae. Field and laboratory investigations of the common American species D. scandens, together with a comparative survey of related species, have thrown some light on these problems. The Dalechampia inflorescence seems best interpreted as consisting of a terminal staminate pleiochasium (with part of the lateral branches transformed for nectar production), juxtaposed to a 3-flowered pistillate cyme. The lips of the conspicuous bilabiate involucre are formed by the hypertrophied bracts which subtend the staminate and pistillate cymes. The bisexual inflorescences appear to be distinctly proterogynous, rather than proterandrous, as has been previously suggested. The configuration of the inflorescence-a bilaterally symmetrical pseudanthium-suggests adaptation for crosspollination, but the closing movement of the bracts makes self-pollination probable in the absence of visits by pollinators. The similarity of the Dalechampia inflorescence to the cyathium of the Euphorbieae appears to be entirely superficial, and both reproductive and vegetative data suggest that Dalechampia is related to taxa of tribe Plukenetieae.
OXYGEN DEFICIENCY IN THE NORTH INDIAN OCEAN DEFICIENCIA DE OXIGENO EN EL OCEANO INDICO NORTE

The Indian Ocean contains one of the oceans' most pronounced oxygen minimum zones (OMZ), which, anomalously, is the most intense in the northwestern sector (Arabian Sea). It also contains the majority of the area of oceanic continental margins in contact with oxygen-depleted waters. Impacts of the oxygen deficiency on regional biogeochemistry, especially anaerobic nitrogen transformations, are described. A comparison of the perennial, mesopelagic OMZ in the open Northwestern Indian Ocean is made with a shallower oxygen deficient system that develops seasonally (during late summer and autumn) over the western Indian shelf. The latter appears to have intensified in recent years presumably due to anthropogenic nutrient loading from land.
Title : NY-ESO-1 TCR single edited central memory and memory stem T cells to treat multiple myeloma without inducing GvHD

Transfer of T cell receptors (TCR) specific for tumor-associated antigens is a promising approach for cancer immunotherapy. We developed the TCR gene editing technology, that is based on the knockout of the endogenous TCR α and β genes, followed by the introduction of tumor-specific TCR genes, and that proved safer and more effective than conventional TCR gene transfer. While successful, complete editing requires extensive cell manipulation and four transduction procedures. Here we propose a novel and clinically feasible ‘single TCR editing’ (SE) approach, based on the disruption of the endogenous TCR α chain only, followed by the transfer of genes encoding for a tumor specific TCR. We validated SE with the clinical grade HLA-A2 restricted NY-ESO-1157-165 specific TCR. SE allowed the rapid production of high numbers of tumor specific T cells, with optimal TCR expression and preferential stem memory and central memory phenotype. Similarly to unedited T cells redirected by TCR gene transfer (TR), single edited T cells killed efficiently NY-ESO-1 targets; however, while TR cells proved highly alloreactive, SE cells showed a favorable safety profile. Accordingly, when infused in NSG mice previously engrafted with myeloma, SE cells mediated tumor rejection without inducing xenogeneic graft versus host disease, thus resulting in significantly higher survival than that observed in mice treated with TR cells. Overall, single TCR gene editing represents a clinically feasible approach, able to increase the safety and efficacy of cancer adoptive immunotherapy. For personal use only. on June 24, 2017. by guest www.bloodjournal. org From
Expectations About the Temporal Structure of the World Result in the Attentional Blink and Repetition Blindness

We consider how repetition blindness and the attentional blink might arise from prior assumptions about the occurrence of task-relevant states of the world. Repetition blindness and the attentional blink are behavioral deficits in the identification of items during rapid serial visual presentation at varying delays after identifying the first “target. ” Here we propose that both of these effects are explained by rational inference given prior expectations about the timing of task-relevant world transitions. While such expectations would be helpful in the natural world, they may result in unanticipated biases in laboratory settings. We show that a rational model using prior expectations of the timing of task-relevant information captures the basic repetition blindness and the attentional blink effects, and also the specific distributions of errors made during the attentional blink.