Miracle-dz/UniFAR-FTUs huggingface dataset:
[Biostratigraphy and paleoecology of the Neogene micromammalian faunas from the Calatayud-Teruel Basin (Spain) / Freudenthal, M. (editor)]: Cricetidae (Rodentia) from the type Aragonian; the genus Megacricetodon

This paper is a detailed study of 10 000 Megacricetodon teeth from 35 localities of Aragonian and early Vallesian age. One new species is described: M. rafaeli sp. nov. from Armantes 7. Evolutionary trends of this group are discussed and a comparison with French and Central European material is made.
Modelagem de tempo de sobrevida via método bootstrap

Em estudos estatisticos de analise de sobrevida, o tempo nao e normalmente distribuido, pois e uma variavel continua que nao admite valores negativos. Sendo assim, as funcoes densidade de probabilidade exponencial, Weibull e lognormal sao as mais utilizadas para modelar tempo de sobrevida. Cada uma dessas funcoes possui suas limitacoes e complexidades quando utilizadas para estimar tempo de sobrevida. O metodo bootstrap consiste de um procedimento estatistico computacionalmente intensivo que permite avaliar diversas estatisticas, com base nos dados obtidos da amostra. Portanto, dentro desse contexto, o objetivo do presente estudo foi apresentar um metodo alternativo para modelar tempo de sobrevida utilizando o metodo bootstrap. Para tanto, foi desenvolvido um programa computacional na linguagem C++. Os resultados obtidos indicaram que o uso do metodo bootstrap na modelagem de tempo de sobrevida, evitou as interferencias estatisticas resultantes da escolha de um modelo de distribuicao de probabilidade.
Avaliação biológica de soja com baixas atividades de inibidores de tripsina e ausência do inibidor Kunitz

The soybean cultivar BR 36 with conventional levels of trypsin inhibitors activity and the soybean line BRM95-5262, which was genetically selected to contain low activity of trypsin inhibitors were used for biological assays with rats. BR 36 and BRM95-5262 contained 40 and 20, and 30 and 20% of relative residual activity of trypsin inhibitors, respectively. The mean values of PER and NPR showed that treatments with crude soybeans were minor than treatments with soybean thermically processed. However, the treatments of thermically processed soybean did not showed significative differences (p > or = 0.05). When the trypsin inhibitors activity were 8.61 and 8.44 UIT/mg of samples or 20 and 30% of relative residual activity of cultivar BR 36 and line BRM95-5262, respectively, it was observed that mean values of PER and NPR were not significatives. The mean values of CDA and CDV of treatments with crude soybeans were minor than treatment with casein and similar to the treatments with soybean thermically processed. So, it can be concluded that the biological evaluation obtained with soybean protein were dependent of initial trypsin inhibitors activities and of its respective thermical treatment. There was advantage in the use of BRM95-5262 soybean line with low trypsin inhibitors activity.
The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans

Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity - Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. * Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists * Provides a novel synthesis of existing ideas about the biology of longevity and aging * Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition
Effect of phytase and vitamin d metabolite (25oh-d3) in turkey diets on phosphorus solubility in manure-amended soils

It has become common practice to use feed additives (such as phytase) to increase the digestibility of phytate-P to monogastric animals, decreasing the need for P supplements to diets and decreasing the total P content in manures. In this study, the effect of incorporating phytase/and 25-hydroxycholecalciferol (250H-D 3 ) in turkey diets on the solubility of P in turkey manures (TMs) and TM-amended soils was investigated. Turkey manures were collected from turkeys fed (i) a normal diet, and three diets containing reduced nonphytate P (nPP) called (ii) P deficient, (iii) phytase, and (iv) phytase+25OH-D3. The TMs were added to five soils at the same total P rate (150 kg P ha -1 ) and incubated for 42 days. The dried TMs were analyzed for water soluble-P (WS-P) and total P, whereas the incubated soils were analyzed for pH, organic matter (OM), Mehlich-3 P, Al, and Fe (M3-P, M3-A1 and M3-Fe), water soluble-molybdate reactive P (WS-MRP), and organic-P (WS-OP). The normal diet produced TMs that had six times higher WS-P and more than 40% greater total P than any of the reduced nPP diets. Adding phytase to the reduced nPP diets did not increase the percentage of total P that was water soluble. As a result of its greater P content, TM from the normal diet increased soil WS-MRP, but not M3-P or WS-OP, to a greater extent than the reduced nPP diets. All TMs increased WS-MRP relative to the unamended soil, and these increases were inversely related to the M3 [Al+Fe] content of each soil. Converting from a normal turkey diet to one that contains reduced nPP and phytase/and 25OH-D 3 shows potential for reducing total and soluble P in manures and soluble P in manure-amended soils. As reduced nPP, phytase/and 25OH-D 3 in diets lead to reduced TM total P, long-term applications of these reduced P TMs using nitrogen-based management would be expected to reduce total P and Mehlich-3 P in soils, compared with TMs from normal diets.
Physiology, stress, and malnutrition : functional correlates, nutritional intervention

This text, based on the proceedings of the third Clintec International Horizons Conference, offers a panoramic view of the effects of nutrition on the human body. An international array of multidisciplinary researchers present their scientific and clinical studies, and discuss results with researchers from divergent but related fields. The editors' aim is to strengthen scientific direction, propel a more rapid incorporation of technical and clinical advances into patient care, and directly improve nutritional care for the critically ill. Coverage includes: human energy metabolism; energy stores and energy balance with focus on the cellular mechanisms; organ systems; the role of nutrition in organ failure; nutritional support strategies; whole body metabolism; and the challenging issues of whole body outcome measures.
Mapeamento de QTLs para caracteres relacionados com a fixação biológica de nitrogênio (FBN) em soja

Mapping QTLs for traits associated with biological nitrogen fixation (BNF) in soybeans Soybeans [Glycine max (L.) Merrill] is a crop with high protein content (about 40%) in the seeds. As a result, the crop demands high nitrogen (N) inputs, which can be supplied by the process of biological nitrogen fixation (BNF), through the symbiosis with bacteria of the genus Bradyrhizobium. In Brazil the BNF allows to fulfill all the demand for N; therefore N fertilizers are not required. However, the traits associated with BNF have not been directly considered in breeding programs due to the difficulties to its evaluation, which require, generally, the plant destruction. The objective of this study was to map Quantitative Trait Loci (QTLs) of traits related to BNF and to identify useful associations for marker-assisted selection, as well as to obtain other information about the genetic basis of these traits in soybeans. A population of 157 F2:7 recombinant inbred lines (RILs), derived from a two-way cross, were genotyped with 105 microsatellite markers as well as evaluated for the following traits related with BNF: number of nodes (NN); nodule dry weight (NDW); mean nodule dry weight (NDW/NN); and shoot dry weight (SDW). Using the composite interval mapping for multiple traits (mCIM) method, the QTLs were mapped for all the traits. A genetic map was constructed with an estimated size of 1,263.2 cM, covering about 50% of the genome. Eight genomic regions were associated with the four traits and four of these regions, located on linkage groups (LG) C1, C2, E and I, were associated with more than one trait: in LG C1 (Satt190-Satt136), QTLs for NDW, NDW/NN and SDW were mapped; in LG C2 (Satt460-Satt307), QTLs for NN and NDW were mapped; in GL E (Satt573-SAtt185), QTLs for SDW and NN were mapped; and in GL I (Satt239-Satt354) QTLs for NDW/NN and NN were mapped. The pleiotropy was attributed to QTL association in the LG C1, C2, and E, whereas genetic linkage was attributed to QTL association in LG I. QTLs affecting only one trait were mapped in LG A2, B1, G and L: in LG A2 (Sct067-Satt589) a QTL was mapped, for NDW/NN; in LG B1 (Satt509-Satt251) a QTL was mapped for NN; in LG L (Satt232-Satt418) a QTL was mapped for SDW; and in LG G (Satt394Satt288) a QTL was mapped for SDW. The QTLs individually explained very little of the phenotypic variation (R = 1.2% to 10.0%), and the most significant QTL was mapped in the LG L, explaining 10.0% of the variation for SDW, with an additive effect of 0.57 g plant. Therefore, QTLs in four regions were detected for SDW (C1, E, G, and L), in five regions for NN (B1, C1, C2, E, and G), in two regions for NDW (C1, and C2) and in three regions for SDW/NN (A2, C1, and I), which explained 23.0%, 20.0%, 11.8% and 16.0% of phenotypic variation, respectively. These results are in agreement with the relatively low heritability of the traits (28% to 49%) and reflect the complex nature of BNF traits, which are influenced by the environmental effects.
ARF6: A NEW PLAYER IN THE FcγRIIIA LYMPHOCYTE-MEDIATED CYTOTOXICITY Running title: A role for Arf6 in lymphocyte-mediated cytotoxicity

(1930 articles) Signal Transduction  (5023 articles) Immunobiology  Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#reprints Information about ordering reprints may be found online at: http://bloodjournal.hematologylibrary. org/site/subscriptions/index.xhtml Information about subscriptions and ASH membership may be found online at:
Preference for Collpa Water by Frugivorous Bats (Artibeus): An Experimental Approach

Several species of stenodermatine bats congregate in large numbers at collpas in southeastern Peru to drink water. We conducted the first experimental tests of preference for collpa water by representative bats. Artibeus species preferred mineral‐rich collpa water over water from other sources, supporting the hypothesis that they seek resources (especially sodium) at collpas.
Relatos y experiencias de profesores colombianos de inglés sobre el Programa Nacional de Bilingüismo: tres retratos que forjan su recorrido de formación

In-service teachers’ continuous education is one of the main lines of action in the National Program of Bilingualism. Building upon the tenets of qualitative research and the method of portraiture, this multiple case study presents three English teachers’ voices working in the basic secondary and higher education. They narrate the experiences they lived in continuous education efforts provided in an Antioquia subregion, within the framework of the bilingualism policy. Data were gathered from documents, semi-structured interviews, and a group in-terview. In short, teachers acknowledge regional agencies have made some efforts to foster teacher professional development. Also, they recognize education approaches because of the benefits in terms of disciplinary strategies and pedagogical knowledge, as well as the opportunity to share with their peers. However, they call the attention about some lack of continuity in the regional in-service education initiatives, a lack of clarity in communication and the socialization of those initiatives, and scheduling conflicts that prevent them to attend to training sessions. We conclude that a policy is needed that (a) reconsiders the ontological educational approach, with teachers being viewed as educational actors, rather than objects, and as political actors in control of their own destiny, and one that (b) promotes continuous education for all in the long term, with a clear track.
COMPARATIVE STUDY ON DIAGNOSIS OF URINARY TRACT INFECTION AMONG ADOLESCENTS IN THE KUMASI METROPOLIS USING DIPSTICK , CULTURE AND PCR METHODS

Urinary tract infection (UTI) is associated with clinical conditions such as hypertension, anaemia, kidney failure and even death. Diagnosis and early detection of UTI are critical measures in the management of the disease. The classical microbiological culture method is hindered by long diagnostic time and characteristic features of certain microbes becoming viable-but-non-culturable (VBNC). Direct PCR is a more sensitive and rapid diagnostic tool for detecting pathogens in clinical samples. This work aimed at developing a simplified PCR assay for detection of uropathogenic Escherichia coli, an index microorganism for UTI and the results compared to two common diagnostic markers – i.e., dipstick and microbiological culture methods. The cross-sectional study involved collection of urine samples from 195 adolescents, aged between 13 and 18 years. DNA segments were amplified using specific primers targeting papC gene for fimbriae formation and the bacteriocin usp gene of the uropathogenic E. coli. Comparing the three diagnostic tools, the PCR produced the highest sensitivity of 71%, and the nitrite-based dipstick method recording the least sensitivity of 3%. Leukocyte esterase-based dipstick recorded the highest specificity of 76% as against 24% specificity by the PCR method. In addition, leukocyte esterase detection dipstick produced the highest values for both positive and negative predictive values of 52% and 76%, respectively. From the receiver operator characteristic (ROC) analyses, PCR showed an area of 0.7231± 0.0262 (age in years X number of positives) over culture method with P value 0.0001, compared to 0.7205± 0.02623 (age in years X number of positives) of culture method over the dipstick method (p< 0.0001). Although the PCR diagnostic method for UTI uropathogenic indicator (E. coli) was found to be superior method as compared to culture and dipstick methods, it should be made a complementary UTI diagnostic tool due to the low specificity.
TRANSMISSION CHARACTERISTICS OF LETTUCE PHYLLODY PHYTOPLASMA BY Neoaliturus fenestratus IN FARS

Phytoplasmal lettuce phyllody (LP) disease previously was reported from Fars province is vectored by Neoaliturus fenestratus leafhopper. Transmission characteristics of LP phytoplasma with N. fenestratus including acquisition feeding, latency and inoculation feeding period were studied. The minimum acquisition access period (AAP) was four hours. Transmission increased with AAP. With an AAP of 48 hours, 88.88 % of plants were infected. The minimum latent period (LP) in N. fenestratus was 14 days and transmission increased after this minimum LP. At 32 days postacquisition, 92.85% of plants were infected, but the rate of transmission gradually decreased. The minimum inoculation access period (IAP) was 4 hours. Transmission increased with IAP. At an IAP of 48 hours, 96.66 % of the plants were infected. Results of this study indicate that the transmission processes of acquisition, latency and inoculation occur in much the same pattern as in other plant pathogenic mollicutes.
Etude du métabolisme du nickel chez Hélicobacter pylori

Le nickel est un metal de transition qui est essentiel a la survie de la bacterie pathogene Helicobacter pylori au sein de sa niche unique, l'estomac humain. En effet, le nickel est le cofacteur de deux proteines indispensables a la virulence de ce pathogene, l'urease et l'hydrogenase. Cependant la concentration intracellulaire de ce metal doit etre strictement controlee car s'il est en exces, il provoque des effets toxiques pour la cellule. Etant donne la basse concentration en nickel dans l'homme, H. Pylori a besoin d'un systeme de transport a haute affinite pour importer suffisamment d'ions nickel. Nous avons montre que le passage les ions nickel a travers la membrane externe de H. Pylori depend egalement du systeme TonB/ExbB/ExbD et du recepteur FrpB4. Des mutants portant des deletions des genes tonB/exbB/exbD ou du gene frpB4 sont affectes dans la capacite a transporter du nickel lors d'une incubation a pH acide. La proteine NikR est un regulateur transcriptionnel qui repond a la concentration intracellulaire en nickel et regule un grand nombre de genes chez H. Pylori. La structure cristallographique de NikR metallee en nickel ou non a ete determinee. Cette etude nous a permis d'identifier des acides amines qui sont impliques dans l'incorporation du nickel a un site de haute affinite et de proposer un mecanisme de fixation du nickel asymetrique dans NikR. Finalement, nous avons caracterise plusieurs proteines de H. Pylori impliquees dans la detoxification du nickel et dans son incorporation au sein des deux metallo-enzymes a nickel. En conclusion, ce travail nous a permis de mieux comprendre la contribution du nickel dans la physiologie et la virulence de H, pylori.
Problemas del metodo de clorofila - luz para estimar productividad del fitoplancton en aguas costeras

The chlorophvll-light method to estimate phytoplankton productivity in coastal zones has had severe limitations. Analytic solutions are based on chlorophyll a and phytoplankton light conditioning being constant with depth and time. On the other side, it is obsolete to estimate relative photosynthesis geometrically, using nomograms. An algebraic expression for relative photosynthesis is given. This can be used for computerized estimations. With the meager data on the photosynthesislight intensity relationship, available in the literature. 1 CIENCIAS MARINAS (Mex) V. 7 (l), 1981 67 http://dx.doi. org/10.7773/cm.v7i1. 358
Variation of ligulate florets in some taxa of the genus Achillea L.

The author distinguished eight forms of variation of ligulate florets in some species of the genus Achillea L. and presented them in figures (Figs 2-9). From them five forms were found in plants of characters intermediate between A. collina Becker and A. millefolium L. s. str. (Table 1). In forms: bipetala, caliciformis and subtubulosa in some florets also the sex was changed – such florets were bisexual, but of different number of stamina. In form tubulosa in all florets the sex was changed, such florets were bisexual, but of different number of stamina. Form heteropetala was observed in the nature and also obtained experimentally by the author through selfpollination of a plant of characters intermediate between A. collina Becker and A. millefolium L. s. str. and A. asplenifolia Vent. It is possible that the described variation of ligulate florets is a result of hybridization especially but may be also the result of some other causes.
Diagnostic Potential of Extant Anti-schistosoma Genus-Specific Monoclonal Antibodies

The suitability o f five Schistosoma genus-specific monoclonal antibodies (MoAbs) (Sh3/34.10, Sh3/38.2, Sh4/14.3, Sh5/32.30 and Sh5/34.10) in detecting schistosome antigens in infected human and cattle was evaluated. These antibodies were employed in various diagnostic assays to diagnose human and animal schistosomiasis. Extant MoAb secreting hybridoma cells were first propagated in culture to produce the MoAbs. The culture supernatants containing secreted antibodies were analysed by immunodiffusion and the isotypes o f the immunoglobulins shown to be IgM (Sh3/34.10, Sh3/38.2, Sh5/32.30 and Sh5/34.10) and IgGl (Sh4/14.3). Gel purified fractions o f the MoAbs were utilised in developing dipstick ELISA and micro-plate ELISA in diagnosing schistosomiasis. Also, the suitability o f the indirect immunoflourescent Antibody Test (IFAT) was employed to demonstrate anti-schistosoma antibodies in the blood o f infected cattle. Three o f the antibodies (Sh3/38.2, Sh4/14.3, Sh5/32.30) showed no cross-reactivity with Plasmodium falciparum circum-sporozoite protein (CSP) and crude antigen extract of P. falciparum. However Sh3/34.10 and Sh5/34.10 reacted with the crude antigen extract o f P. falciparum at high antibody concentrations even though the reactivity was abrogated at higher antibody titres. In human schistosomiasis, the diagnostic potential o f the MoAbs in detecting schistosome antigens were assessed alongside microscopy and the standard Sh2/15.F urinary schistosomiasis dipstick ELISA developed by researchers at the NMIMR. Out o f 74 human subjects from a schistosomiasis endemic area screened for urinary schistosomiasis, 81.1% were microscopically positive for S. haematobium eggs whilst the standard dipstick assay gave prevalence estimate o f 87.3%. The sensitivity o f this assay was 100% whereas the specificity was 64.7% compared with microscopy as the gold standard test. Dipstick assays utilizing the individual Schistosoma genus-specific monoclonal antibodies estimated prevalences o f urinary schistosomiasis between 48.6 and xii University of Ghana http://ugspace.ug. edu.gh