Miracle-dz/UniFAR-FTUs huggingface dataset:
Control of Spin Defects in Wide-Bandgap Semiconductors for Quantum Technologies

Deep-level defects are usually considered undesirable in semiconductors as they typically interfere with the performance of present-day electronic and optoelectronic devices. However, the electronic spin states of certain atomic-scale defects have recently been shown to be promising quantum bits for quantum information processing as well as exquisite nanoscale sensors due to their local environmental sensitivity. In this review, we will discuss recent advances in quantum control protocols of several of these spin defects, the negatively charged nitrogen-vacancy (NV-) center in diamond and a variety of forms of the neutral divacancy (VV0) complex in silicon carbide (SiC). These defects exhibit a spin-triplet ground state that can be controlled through a variety of techniques, several of which allow for room temperature operation. Microwave control has enabled sophisticated decoupling schemes to extend coherence times as well as nanoscale sensing of temperature along with magnetic and electric fields. On the other hand, photonic control of these spin states has provided initial steps toward integration into quantum networks, including entanglement, quantum state teleportation, and all-optical control. Electrical and mechanical control also suggest pathways to develop quantum transducers and quantum hybrid systems. The versatility of the control mechanisms demonstrated should facilitate the development of quantum technologies based on these spin defects.
The effects of different types and doses of oestrogen replacement therapy on clinic and ambulatory blood pressure and the renin-angiotensin system in normotensive postmenopausal women.

OBJECTIVE The effect on blood pressure of oral replacement' doses of exogenous oestrogen may depend on the type and dose of oestrogen administered. This study was designed to compare with placebo the effect of once daily treatment with a 'natural' oestrogen, piperazine oestrone sulphate, in two different doses and a semisynthetic oestrogen, ethinyloestradiol, on clinic and ambulatory blood pressure and the renin-angiotensin system in postmenopausal women. DESIGN AND METHODS Twenty-four normotensive postmenopausal women (median age 54 years, range 47-60 years) participated in the study which used a double-blind crossover design. For each subject there were four randomized treatment phases, each lasting 4 weeks. The separate treatments administered once daily were 0.625 mg oestrone sulphate, 2.5 mg oestrone sulphate, 0.02 mg ethinyloestradiol and matching placebo. Clinic blood pressure, heart rate and weight were measured weekly with the mean values of weeks three and four of each phase used for analysis. Ambulatory blood pressure and biochemical measurements were performed in the final week of each phase. RESULTS Twenty-four subjects entered and 22 completed the randomized phases of the study. Compared with the placebo phase, end-of-phase mean clinic diastolic blood pressure was reduced in subjects taking the semisynthetic oestrogen (P < 0.01) but was unchanged in those taking the 'low' and 'high' dose natural oestrogen. Mean clinic systolic blood pressure was also unchanged by any of the oestrogen treatments. Ambulatory night-time systolic, diastolic and mean arterial blood pressures were reduced with the low-dose natural and semisynthetic oestrogen treatments compared with placebo (P < 0.01), whereas there was no significant effect of the oestrogen treatments on ambulatory daytime blood pressures. A reduction in clinic and ambulatory heart rate was observed with the high-dose oestrone and semisynthetic oestrogen treatments. There was a dose-dependent increase in plasma renin substrate and decrease in plasma renin concentration with all active treatments; however, there was no change in plasma renin activity or plasma aldosterone concentration. CONCLUSION In normotensive postmenopausal women, replacement doses of natural and semisynthetic oestrogen reduce night-time ambulatory blood pressure with either no change or a small reduction in clinic blood pressure. Reduction in blood pressure is not explained by reduced activity of the renin-angiotensin system but could have a component of reduced central sympathetic drive consistent with the decreased heart rate.
Role of nitric oxide in regional blood flow in angiotensin II-induced hypertensive rats.

The present study was designed to evaluate the contribution of nitric oxide (NO) to regional hemodynamics during the early phase of angiotensin II (Ang II)-induced hypertension. The responses of regional blood flow to chronic NO synthase inhibition with N(G)-nitro-L-arginine methyl ester (L-NAME) were assessed using radioactive microspheres in conscious Ang II-infused hypertensive rats. Ang II-infused rats (270 ng/kg/min, subcutaneously for 12 days: n=11) showed higher mean arterial pressure (MAP: 153+/-4 mmHg) and total peripheral resistance (TPR: 1.61+/-0.06 mmHg/min/ml), and lower cardiac output (CO: 102+/-3 ml/min) than vehicle-infused normotensive rats (115+/-2 mmHg, 0.96+/-0.05 mmHg/min/ml and 130+/-7 ml/min, n=11, respectively). The blood flow rates in the brain, spleen, large intestine and skin were significantly reduced in Ang III-infused rats compared with vehicle-infused rats, while those in the lung, heart, liver, kidney, adrenal gland, small intestine, and skeletal muscle were similar. Treating Ang II-infused rats with L-NAME (75 mg/l in drinking water for 10 days, n=11) resulted in higher MAP (166+/-6 mmHg) and TPR (1.89+/-0.18 mmHg/min/ml) and lower CO (87+/-7 m/min) than untreated Ang II-infused rats. L-NAME-treated Ang II-infused rats showed widespread increases in regional vascular resistance and reduced blood flow rates in the kidney (3.81+/-0.27 ml/min/g) and skeletal muscle (0.20+/-0.03 ml/min/g) compared with untreated Ang II-infused rats (6.88+/-0.27 and 0.33+/-0.04 ml/min/g, respectively). However, there were no significant differences in the flow rates of other organs investigated between these animals. An NO donor, (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (FK409: 30 microg/kg/min, i.v.), significantly decreased MAP (110+/-6 mmHg) and TPR (1.23+/-0.18 mmHg/min/ml) without significant changes in CO (89+/-9 ml/min) in L-NAME-treated Ang II-infused rats. Furthermore, FK409 partially reversed blood flow rates in the kidney (4.72+/-0.40 ml/min/g) and skeletal muscle (0.25+/-0.02 ml/min/g)in these animals. These results suggest that NO counteracts, at least in part, the vasoconstrictor effects of elevated Ang II levels in renal and skeletal muscle vascular beds, and is an important modulator in the regulation of blood flow to these organs during the development of Ang II-induced hypertension.
Navigating stroke care: the experiences of younger stroke survivors

Abstract Purpose: Although stroke is associated with ageing, a significant proportion of strokes occur in younger people. Younger stroke survivors have experienced care available as inappropriate to their needs. However, insufficient attention has been paid to how the social context shapes their experiences of care. We investigated this question with younger stroke survivors in Greater London, UK. Method: We conducted in-depth interviews with individuals aged between 24 and 62 years. Interviews were analysed thematically, with interpretation informed by Bourdieu’s concepts of field, capital and habitus. Results: In the acute care setting it was implicit for participants that expertise and guidance was to be prioritised and largely this was reported as what was received. Individuals’ cultural capital shaped expectations to access information, but health care professionals’ symbolic capital meant they controlled its provision. After discharge, professional guidance was still looked for, but many felt it was limited or unavailable. It was here that participants’ social, cultural and economic capital became more important in experiences of care. Conclusions: The field of stroke shaped younger stroke survivors’ experiences of care. Navigating stroke care was contingent on accessing different forms of capital. Differences in access to these resources influenced longer term adjustment after stroke. Implications for Rehabilitation Stroke care can be conceptualised as a temporal field of social activity and relationships which shapes variations in experiences of care among younger stroke survivors, and differences in expectations of support at different time points after stroke. On entering the field of stroke participants reported needing health care professional guidance and expertise to manage the acute event, yet difficulties accessing information in hospital limited the agency of some individuals wanting to take an active role in their recovery. After discharge from hospital variations in experiences of care among participants were more evident, with a number still seeking professional guidance, and requiring the capital and agency to navigate the field of stroke. Despite international efforts to improve the quality of acute care, effective models of community stroke care still need to be developed.
Model for end‐stage liver disease (MELD) exception guidelines

Russell Wiesner, John R. Lake, Richard B. Freeman, and Robert G. Gish Mayo Clinic Foundation, Rochester Minnesota; Department of Medicine and Division of Gastroenterology, University of Minnesota, Minneapolis, MN; Department of Surgery Tufts New England Medical Center, Boston, MA; and Departments of Medicine and Transplantation and the Division of Hepatology and Complex GI, Physicians Foundation, California Pacific Medical Center, San Francisco, CA
Do diabetic veterans use the Internet? Self-reported usage, skills, and interest in using My HealtheVet Web portal.

OBJECTIVE The Veterans Health Administration has developed My HealtheVet (MHV), a Web-based portal that links veterans to their care in the veteran affairs (VA) system. The objective of this study was to measure diabetic veterans' access to and use of the Internet, and their interest in using MHV to help manage their diabetes. MATERIALS AND METHODS Cross-sectional mailed survey of 201 patients with type 2 diabetes and hemoglobin A(1c) > 8.0% receiving primary care at any of five primary care clinic sites affiliated with a VA tertiary care facility. Main measures included Internet usage, access, and attitudes; computer skills; interest in using the Internet; awareness of and attitudes toward MHV; demographics; and socioeconomic status. RESULTS A majority of respondents reported having access to the Internet at home. Nearly half of all respondents had searched online for information about diabetes, including some who did not have home Internet access. More than a third obtained "some" or "a lot" of their health-related information online. Forty-one percent reported being "very interested" in using MHV to help track their home blood glucose readings, a third of whom did not have home Internet access. Factors associated with being "very interested" were as follows: having access to the Internet at home (p < 0.001), "a lot/some" trust in the Internet as a source of health information (p = 0.002), lower age (p = 0.03), and some college (p = 0.04). Neither race (p = 0.44) nor income (p = 0.25) was significantly associated with interest in MHV. CONCLUSIONS This study found that a diverse sample of older VA patients with sub-optimally controlled diabetes had a level of familiarity with and access to the Internet comparable to an age-matched national sample. In addition, there was a high degree of interest in using the Internet to help manage their diabetes.
Role of Epstein-Barr Virus in the Development of Nasopharyngeal Carcinoma

Abstract Southern China experiences larger extent of total cancer pathologies, of which nasopharyngeal carcinoma has the highest incidence under otorhinolaryngeal malignant carcinomas. Risk factor of nasopharyngeal carcinoma varies from hereditary causes to virus infection, among which Epstein-Barr virus (EBV) infection is the mostly investigated. The study into mechanism of EBV in occurrence, development and prognosis of nasopharyngeal carcinoma has been studied for several decades. The pathophysiology in making of EBV into a cancerogen includes proteins as latent membrane protein 1 (LMPs) and nucleic acids as micro-RNAs. In this paper, we reviewed till date studies focusing on relationship between EBV and nasopharyngeal carcinoma.
Prolonged Elevation of Intracellular Cyclic AMP Activates Interleukin‐1 Production in Human Peripheral Blood Monocytes

The capability of elevated intracellular cyclic AM P concentration to activate IL‐l gene expression and protein production was examined in human peripheral blood monocytes. In accordance with previous studies it was observed that the transiently elevated cyclic AMP (induced either with prostaglandin E2 or with the direct adenylate cyclase activator, forskolin) was not a sufficient signal to activate IL‐l production. However, if the degradation of cyclic AMP was inhibited with isobutyl‐methyl‐xanthine (IBMX). IL‐l production was strongly activated. This prostaglandin E2 plus IBMX effect could also be mimicked with high concentrations of the cell permeant structural cyclic AMP analogue, dibutyryl cyclic AMP. The cyclic AMP4nduced IL‐l production differed in some aspects from the bacterial lipopolysaccharide‐induced IL‐l production: (1) the kinetics of both IL‐l gene expression and protein production was much slower: (2) the IL‐1β gene expression was superinducible by inhibiting the protein synthesis with cycloheximide. Thus these data suggest that prolonged elevation of cyclic AMP is alone a sufficient signal to activate IL‐l production.
Design and New Control of DC/DC Converters to Share Energy Between Supercapacitors and Batteries in Hybrid Vehicles

In this paper, the authors propose the supercapacitor integration strategy in a hybrid series vehicle. The designed vehicle is an experimental test bench developed at the laboratory of electrical engineering and systems (L2ES) in collaboration with the research in electrical engineering and electronics center of Belfort (CREEBEL). This test bench currently has two diesel motors (each connected to one alternator) and lead-acid batteries with a voltage rating of 540 V and a fluctuation margin between +12% and -20% of the rated voltage. The alternators are connected to the dc link by rectifiers. An original strategy of the supercapacitor integration in this vehicle with their control is presented to find a better compromise between the dimensions of the embarked devices, the share energy efficiency, the dynamics of the supply, and the electric power storage. The supercapacitor packs are made up of two modules of 108 cells each and present a maximum voltage of 270 V. The main objective is to provide a peak power of 216 kW over 20 s from supercapacitors to the dc link. Various topologies of dc/dc converters are presented with effective methodologies of electric power management in the hybrid vehicle.
A histopathological study of Hudson River crayfish, Orconectes virilis, exposed to platinum group metals

Platinum group metals (PGMs), such as platinum (Pt), palladium (Pd), and rhodium (Rh), are of increasing concern due to rising anthropogenic input to aquatic systems. In this study, PGMs’ effects on bioaccumulation and histopathological changes were investigated using Orconectes virilis, a native Hudson River crayfish, as a model. Organisms were exposed to varying concentrations of water-soluble PGM salts for 10 days. The following experimental treatments were established: 0.0, 1.0, 5.0, 10.0 ppm Pt(IV), 1.0 ppm Rh(III), 1.0 ppm Pd(II), and a PGM mix (1.0 ppm Pt(IV), Rh(III), Pd(II) each) dissolved in raw Hudson River water. Metal content in the tissue samples were analyzed by a Spectro Genesis ICP-OES. The relationship between Pt, Pd, and Rh concentrations in different treatments and observed behavioral changes during the experiment was analyzed through One-Way ANOVA Student-Newman-Keuls multiple comparison test (P ≤ 0.05). Paraffin sections, 6-μm-thick, were prepared in standard eosin-Y and hematoxylin-2 stain and examined for histological abnormalities within hepatopancreas, exoskeleton, brain, and ganglia tissue. Statistically significant differences in PGM bioaccumulation were observed in all organs, with highest concentrations found in the hepatopancreas, 81.68 mg g−1 dw in 1.0 ppm Pd treatment, 20.03 mg g−1 dw Rh in 1.0 ppm Rh treatment, and 81.58 mg g−1 dw Pt in the 5.0 ppm Pt treatment. Pt bioaccumulation in the hepatopancreas and exoskeleton decreased at the highest Pt exposure treatment, suggesting severe structural damage to tissue. Hyper-segmentation of vacuoles and swelling of the vascular channels were observed in the hepatocyte structure of the hepatopancreas. Exoskeleton exhibited visible bands in the exocuticle indicating demineralization. Brain and ganglia demonstrated extensive vacuolization. Behavioral analysis showed an increase of maximum response intensity over the experimental period within each treatment. Bioaccumulation and cellular abnormalities observed in exposed aquatic organisms raise concern of PGM bio-magnification within the food chain and its effect on the environment and human health.
Ice contamination of Meteosat/SEVIRI IR13.4 channel implied by Inter-Calibration against Metop/IASI

The inter-calibration of the infrared channels of the geostationary Meteosat/SEVIRI satellite instruments shows most channels are radiometrically consistent with Metop-A/IASI, which is used as a reference instrument. However, the 13.4 μm channel shows a cold bias of ~1 K in warm scenes, which changes with time. This is shown to be consistent with the contamination of SEVIRI by a layer of ice ~1 μm thick building up on the optics, which is believed to have condensed from water outgassed from the spacecraft. This modifies the spectral response functions and hence the weighting functions of channels in stronger atmospheric absorption bands, thus introducing an apparent calibration error. Analysis of the radiometer's gain using views of the on board black body source and cold space confirm a loss consistent with transmission through a layer of comparable thickness, which also increases the radiometric noise - especially for channels near the 12 μm libration band of water ice. Inter-calibration, such as the Global Space-based Inter-Calibration System (GSICS) Correction, offers an empirical method to correct this bias.
Altered age-dependent modulation of tissue renin messenger RNA levels in the spontaneously hypertensive rat

Objective To evaluate the possible role of tissue renin overproduction in the pathogenesis and time course of hypertension development in the spontaneously hypertensive rat (SHR) of the Okamoto strain by measuring tissue renin gene expression at different stages of hypertension development Design Measurements of kidney, adrenal gland and brain stem renin messenger RNA( mRNA) levels were performed in SHR aged 4, 12, 20 and 36 weeks and in age-matched normotensive Wistar-Kyoto (WKY) rats Methods A fully quantitative, competitive reverse transcriptase polymerase chain reaction method was used to measure tissue renin mRNA levels. Plasma renin concentrations were measured by radioimmunoassay Results Compared with age-matched WKY rats, renin mRNA levels in the adrenal gland of SHR were significantly higher at ages 4,12 and 36 weeks. Brain stem renin mRNA levels were significantly higher in SHR than in WKY rats at ages 4, 12 and 20 weeks. In contrast, renal renin mRNA levels were consistently lower in SHR at all ages, as were plasma renin concentrations Conclusions The present study indicates an important role for renin gene expression both in adrenal and in brain stem tissues in the pathogenesis of hypertension in SHR. Adrenal and brain renin-angiotensin systems may interact with each other synergistically in the development and maintenance of hypertension in SHR. Suppressed renal renin gene expression could then be an indirect consequence of the amplified renin-angiotensin system in the adrenal gland and in the brain or a baroreceptor-mediated consequence of its hypertension
Jitter peaking investigation in charge pump based clock and data recovery circuits

Jitter transfer function of a clock and data recovery circuit (CDR) must satisfy difficult specifications versus of loop bandwidth and jitter peaking. This paper describes the method of setting poles and zero in third order CDR circuit to keep jitter peaking below a certain value required by specific optical standards. The results are validated by MATLAB simulations for a 10 Gb I s clock and data recovery circuit with an approximately 1MHz bandwidth.
Circularly polarized square patch antenna with improved axial ratio bandwidth

This paper proposes and analyses a circularly polarized square patch antenna with an improved axial ratio bandwidth covering a frequency of 1.665GHz to 1.845GHz. The antenna attains circular polarization using the perturbations — truncated corners and well-shaped slots embedded on the patch. The results indicate that the antenna attains desirable axial ratio (below 3dB) for a wide elevation range of −134° to 47°. When compared to conventional truncated corner circularly polarized square patch antenna, the axial ratio bandwidth of the proposed antenna is increased by 30MHz. The antenna model is fabricated, tested and the measured results show a high correlation with the predicted ones.
Socio-Ecological Intervention to Promote Active Commuting to Work: Protocol and Baseline Findings of a Cluster Randomized Controlled Trial in Finland

Active commuting to work (ACW) is beneficial to traffic, environment and population health. More evidence is needed on effective ways to promote ACW. This paper describes the protocol and baseline findings of a cluster-randomized controlled study, which aims to promote ACW with multilevel strategies in two large workplace areas in Tampere, Finland. In Phase 1, the impacts of environmental strategies (trail improvements) were evaluated in 11 workplaces within Area 1. In Phase 2, five more workplaces were recruited from Area 2 to evaluate the impacts of social and behavioral strategies customized for each workplace. For this purpose, the workplaces in both areas were randomly assigned into experimental group (EXP, n = 6 + 2), which promoted ACW with social and behavioral strategies or into comparison group (COM, n = 5 + 3), which participated in the data collection only. The primary indicator in both phases is the change in employees’ ACW. Secondary indicators are e.g., changes in employees’ self-rated health, wellbeing at work, restrictions to and motivation for ACW, adverse effects due to ACW and the use and quality of the main walking and cycling trails. Also process, efficiency and environmental evaluation is included. The study is the first one in Finland to combine interdisciplinary collaboration between practitioners and researchers working in the fields of transportation, urban design, physical activity and sustainable development to promote ACW. The findings benefit all stakeholders interested in promoting ACW in urban context.