Miracle-dz/UniFAR-FTUs huggingface dataset:
Neuroendocrine differentiation as an indicator of chemosensitivity and prognosis in nonsmall cell lung cancer

Context: Nonsmall cell lung cancers with neuroendocrine differentiation (NSCLC-ND) may demonstrate biologic behavior intermediate between NSCLC and small cell lung cancer (SCLC) with impact on prognosis. Methods: We analyzed 116 consecutive patients with Stage III and IV NSCLC who were diagnosed and treated between 2001 and 2006. Using immuno-histochemical staining for neuron-specific enolase (NSE), chromogranin A (ChrA), and synaptophysin (Syn), 29 (25%) NSCLC-ND were identified. Results: Expression of NSE was present in 22.4%, ChrA in 15.5% and Syn in 14.8% of patients with NSCLC. Therapeutic response was significantly better in the NSCLC-ND group and specimens with > 30% neuroendocrine (NE)-differentiated tumor cells showed favourable therapeutic response (P < 0.05). Multivariate binary logistic regression showed that percentage of NE positive tumor cells was a significant independent prognostic factor associated with a favourable outcome. Receiver operating characteristic (ROC) curves and areas under ROC curves confirmed that percentage of NE-differentiated tumor cells could be useful prediction factor of therapeutic response. Moreover, according to percentage of NE-differentiated tumor cells, optimal cutoffs and related sensitivities and specificities were determined for each markers. Conclusion: Advanced-stage NSCLC with NE tumor cells are clinically less aggressive tumors. Percentage of NE-differentiated tumor cells identifies patients with favourable therapy response to paclitaxel-cisplatin
Hacia el manejo de una herramienta por un robot NAO usando programación por demostraci ón Towards tool handling by a NAO robot using progra mming by demonstration

Resumen La programacion por demostracion es una tecnica, donde, al contrario de la programacion detallada que convencionalmente se hace al robot, este aprende a partir de una o varias demostraciones por parte de un humano u otro robot. Se presenta una tecnica que permite a un robot humanoide, llevar una herramienta hasta la cabeza de un tornillo, siguiendo una trayectoria similar a las trayectorias demostradas por un ser humano. Ademas, permite variaciones en la ubicacion y orientacion de la cabeza del tornillo. Esto se logra gracias al uso de tecnicas de vision de maquina y de modelos probabilisticos estimados a partir de las trayectorias de las demostraciones. El procesamiento de la imagen consistio en la segmentacion en el espacio de color, la seleccion de puntos de interes de la cabeza del tornillo y a partir de estos el calculo de su posicion y orientacion. La trayectoria que se requiere ante las variaciones, se genera usando la tecnica de modelo de mezclas de Gaussianas parametrizado en la tarea. A traves de graficas de las nuevas trayectorias e imagenes de la secuencia del robot ejecutando estas trayectorias, se muestra el funcionamiento de la tecnica. Pese a algunas limitaciones de la plataforma robotica utilizada, se lograron resultados aceptables.
Title : Phototropism : translating light into directional growth

page Phototropism allows plants to align their photosynthetic tissues with the incoming light. The direction of incident light is sensed by the phototropin family of blue light photoreceptors (phot1 and phot2 in Arabidopsis) which are light activated protein kinases. The kinase activity of the phototropins and phosphorylation of residues in the activation loop of their kinase domain are essential steps for the phototropic response. Nevertheless, it remains rather poorly understood how these initial steps are connected to the formation of an auxin gradient across the hypocotyl which, once established, results in asymmetric growth through a series of steps that are starting to be elucidated. In this review we cover the major steps leading from light perception to the directional growth response concentrating on Arabidopsis. In addition we highlight links connecting the different steps.
Efficiency of the Clinical Veterinary Diagnostic Practices and Drug Choices for Infectious Diseases in Livestock in Bangladesh.

As in most low-income countries, adequate laboratory facilities are not available in Bangladesh to assist veterinarians in diagnosing animal diseases. We aimed to determine the efficiency of veterinary diagnoses for two common ruminant diseases in Bangladesh: Peste des petits ruminants (PPR) and foot-and-mouth disease (FMD). We conducted the study from May 2009 to August 2010 in three government veterinary hospitals where veterinarians collected samples from sick livestock and recorded the presumptive diagnosis on the basis of clinical presentations. Samples were tested for PPR and FMD using real-time RT-PCR. We estimated the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the presumptive diagnoses when compared to laboratory tests. We tested 539 goats for PPR and 340 cattle and goats for FMD. Our results indicate that the veterinarians' presumptive diagnoses were different from laboratory findings for both PPR (P < 0.05) and FMD (P < 0.05). The overall sensitivity of the presumptive clinical diagnoses was 54% (95% CI: 47-61%) while specificity was 81% (95% CI: 78-84%) compared to real-time RT-PCR tests. The kappa value obtained in our validation process for PPR (kappa: 0.25) and FMD (kappa 0.36) indicated a poor performance of the presumptive diagnoses. Most of the animals (93%) were treated with antibiotics. Our findings indicate that veterinarians can detect animals not infected with FMD or PPR but miss the true cases. The clinical competency of these veterinarians needs to be improved and access to laboratory diagnostic facilities could help veterinarians to improve the diagnostics and outcomes. The rational use of antibiotics by veterinarians in animals must be ensured.
Depressive Symptoms in Parkinson Disease: Degree of Association and Rate of Agreement of Clinician-Based and Self-Report Measures

Depression in Parkinson disease (PD) is associated with faster disease progression, lower activities of daily living, and more severe cognitive impairment. Even mild symptoms of depression may impact outcomes in patients with PD. Nevertheless, a low rate of agreement has been reported between patient and clinician ratings of depression, suggesting that clinicians may underestimate depression in patients with PD. However, to accurately compare the rates of agreement, comparable estimates are needed so that patient and clinician ratings have similar meaning (eg, mild, moderate, severe, etc). The purpose of this study was to examine this question by investigating the degree of association and rate of agreement of levels of symptom severity among self-report and clinician ratings using established cutoffs that correspond to more comparable estimates of these levels for both patient and clinician. Our findings suggest that patient’s self-report of depressive symptoms was significantly correlated with clinician-based report irrespective of the stage of disease. Moreover, patients demonstrated a 72% rate of agreement with clinicians in classifying symptoms as asymptomatic, mildly symptomatic, or fully symptomatic, a rate significantly higher than the rate of 35% previously reported. This difference in rate of agreement may be accounted for using varying criteria for severity levels across the studies. Findings suggest that clinician and patient reports show a high rate of agreement across a range of depressive symptoms and that self-report measures may provide a relatively efficient means of detecting depressive symptoms especially if patients are disinclined to initiate their report.
Three-Phase Grid Connected ZCT Inverter integrated Photovoltaic Systems

When ac loads are fed through inverters it required that the output voltage of desired magnitude and frequency be achieved. Low leakage current and high efficiency are two key indexes for transformer less PV grid-connected inverter. The transformer less inverter topologies have superior efficiency thanks to saving transformer, but their semiconductor devices are still on hard-switching state at present. A variable output voltage can be obtained by varying the input dc voltage and maintaining the gain of the inverter constant. On the other hand, if the dc input voltage is fixed and it is not controllable, a variable output voltage can be obtained by varying the gain of the inverter, which is normally accomplished by pulse-width-modulation (PWM) control within the inverter. First and foremost, a novel zero current-transition (ZCT) concepts for the threephase full-bridge transformer less PV grid-connected inverters are presented in this paper. Second, the zerocurrent turn-off for high-frequency main switches of the inverters and the zero-current turn-on for auxiliary switches added are achieved by introducing two resonant tanks. Furthermore, a family of ZCT transformer less grid connected inverters with sinusoidal pulse width modulation is deduced.
The ABCD of anti-hypertensive therapy?

While the study was limited to 34 patients under the age of 55 years, its systematic cross-over design, substantially reduced variation. This enabled the authors to con®rm that patients do vary reproducibly in their response to initial treatment with amlodipine, doxazosin, lisinopril, bisoprolol, bendro ̄uazide and placebo. Each of the ®ve drugs was `best' for some patients, and in six and 12 patients, respectively, the `best' drug lowered systolic and diastolic blood pressure by 10 and 5 mmHg more than any other drug. The ®rst drug in the rotation was `best' in only four of 34 patients. Only six patients reached goal blood pressure (systolic pressure , 140 mmHg) on their ®rst active treatment in the rotation. It was noteworthy that there were no signi®cant differences in quality of life or adverse events between placebo and any of the active drugs.
Potassium transport in Langendorff‐perfused mouse hearts assessed by 87Rb NMR spectroscopy

We studied the fluxes of a potassium congener (Rb+) in mouse hearts by 87Rb MRS at 8.4T. The hearts were loaded with Rb+ by perfusion with Krebs‐Henseleit buffer, in which 50% of K+ was substituted with Rb+. We initiated Rb+ efflux by changing the perfusion medium to Rb+‐free buffer. Spectra were acquired every 1.85 min, and the kinetics of Rb+ transport were analyzed by means of monoexponential fits. The rate constants of Rb+ uptake and efflux were 0.0680 ± 0.0028 and 0.0510 ± 0.0051 min–1, respectively (∼30% faster than in the rat heart). The ATP‐sensitive potassium channel opener, P‐1075 (5 μM), and mitochondrial uncoupler, 2,4‐dintrophenol (50 μM), activated Rb+ efflux from mouse hearts by ∼35%. The mechanisms responsible for the differences in Rb+ uptake and efflux under baseline conditions and stimulation, in comparison with rat hearts, are discussed. These data provide a background for studies of cardiac potassium transport in transgenic mouse strains. Magn Reson Med 53:1172–1176, 2005. © 2005 Wiley‐Liss, Inc.
Description grammar for discourse

This work presents the Logical Description Grammar framework of discourse interpretation, and applies the model in the domain of anaphora resolution and presupposition theory. The purpose of the enterprise is to provide what might be called a common language for the specification of discourse theory. Much of current research in linguistics and discourse semantics focuses on highly specialised issues. Moreover, it employs a number of different formal representation systems, so that the analyses provided are sometimes hard to compare. Although it is unavoidable that alternative treatments of one and the same topic arise in a field of research where we may meet with uncertainties of various kinds, such a dispersion of linguistic findings need not be accepted. Even when we concentrate on details or isolated phenomena, linguistic theory is essentially a theory of the whole of a language user’s linguistic capabilities. Analyses of different topics must be combined so that they may help to evaluate and strengthen each other. The LDG framework of discourse interpretation is a flexible system which allows much freedom in setting the parameters of discourse theory. As such it may help to integrate and compare findings currently spread over different approaches or spelled out in different formal theories. Thus, a shared discourse theoretical perspective may be developed. The LDG framework is a reasoning system, the central component of which is a so-called Logical Description Grammar (LDG) for discourse. The grammar represents the language user’s linguistic knowledge. To obtain the full meaning of a discourse, however, linguistic knowledge is not enough. Language users employ world knowledge and knowledge of what is normally the case as well. They are able to infer a most plausible interpretation of a discourse, given their combined linguistic and nonlinguistic knowledge.
[Predictive models for complex diseases].

UNLABELLED The Non Communicable Complex Disease (NCCD) are the leading causes of death in the world, causing more deaths each year than all other combined causes. The approximately 80% of deaths were caused by NCCD and occured in low and middle income countries. However, NCCD deaths could be avoided by prevention programs and early diagnosis. The challenge of the multifactorial phenotypes is to achieve a valid strategy for identifying risk individuals at the population. These strategies may be addressed to screening population or generating causal predictive models for early detection, interpreting the root causes that create the condition. The aim of this paper is to describe the characteristic of complex chronic diseases and some of the current methods of study of these in the health area . CONCLUSIONS Interdisciplinary work, a team of health professionals belonging to different areas allows for an adequate management of complex diseases. The application of graph models, such as DAG's, is a valuable tool for a better adjustment of the statistical model, which allows an appropriate correspondence with the actual health model of these illnesses. And the best methodological strategy for complex diseases is the early diagnosis and the monitoring of risk groups and therapy monitoring of patients diagnosed.
Définition et potentiel de dénomination d’une nomenclature

Citer cet article Portelance, C. (1990). Définition et potentiel de dénomination d’une nomenclature. TTR : traduction, terminologie, rédaction, 3(1), 99–124. https://doi.org/10.7202/037061ar Ce document est protégé par la loi sur le droit d'auteur. L'utilisation des services d'Érudit (y compris la reproduction) est assujettie à sa politique d'utilisation que vous pouvez consulter en ligne. [https://apropos.erudit. org/fr/usagers/politique-dutilisation/]
Coordination and control of a group of small mobile robots

The task of coordinating and controlling a group of small mobile robots may be decomposed into five subtasks: formation of geometric pattern, alignment of each robot's orientation, coordination of the robots in the group, motion realization and stability of the formation in motion. The technique of imposing constraint conditions is utilized to coordinate and control the formation. Group stability is presented in terms of the bound of the transient response of the formation system. <<ETX>>
Prevalence and determinants of smoking in three regions of Saudi Arabia

OBJECTIVES To study the prevalence and determinants of cigarette smoking among Saudi nationals in three regions of Saudi Arabia. PARTICIPANTS A sample of 8310 individuals aged 15 years and above from both sexes, randomly selected from the three regions, using a stratified cluster sampling technique. DESIGN A cross-sectional, household, community-based survey. Using a predesigned and tested questionnaire, the participants were interviewed by primary care physicians. The interview covered personal, social, and educational characteristics of the respondents, and also included questions about their smoking status, duration of smoking, and daily cigarette consumption. MAIN OUTCOME MEASURES Association between current smoking and sociodemographic variables, in univariate and multivariate analysis. Degree of interaction between the different determinants of cigarette smoking. RESULTS The overall prevalence of current smoking was 21.1% for males and 0.9% for females. Most smokers (78%) were young to middle-aged (21–50 years old). Smoking prevalence was higher among married people, among uneducated people, and among those in certain occupations: manual workers, businessmen, army officers, and office workers. CONCLUSIONS Cigarette smoking is an important public health problem in Saudi Arabia. A more intense and comprehensive tobacco control effort is needed.
THE ACUTE EFFECTS OF A SINGLE SET OF CONTRAST PRELOADING ON A LOADED COUNTERMOVEMENT JUMP TRAINING SESSION

The aim of this research was to assess the effect of a single set of contrast preloading on peak vertical displacement (PD) during a loaded countermovement jump (LCMJ) training session. Nine strength-trained males participated in 2 randomly assigned, crossover design testing sessions consisting of 5 sets of 6 repetitions of 20-kg LCMJs with 3-minute rest intervals between sets. The preloading intervention was performed 3 minutes after the first set and 4 minutes before the second set of 20-kg LCMJs. The control (CON) group performed 1 set of 20-kg LCMJs, whereas the jump squat (JS) group performed 1 set of 40-kg LCMJs. The number of repetitions performed during each preloading condition was varied to match total concentric work between the 2 sessions. A significant (p < 0.05) preload 3 set interaction for PD was observed, with the JS group jumping significantly higher during the third set performed after the preload in comparison with the CON group. Analysis of peak power output and mean power output during the concentric movement for this set revealed that as the knee flexion angle increased, the effect of the preload was augmented. These results suggest that a single set of preloading exercises enhances performance during a lower-body explosive power training session; however, the effects of a single preloading set may not peak until midway through the training session.
Dinamika titra specifičnih IgG protutijela u liječenju Helicobacter pylori infekcije primjenom terapijskog protokola s azitromicinom

Budu}i da do sada, ni jednim terapijskim protokolom, nije zabilje`en 100 % u~inak na eradikaciju Helicobacter pylori (HP), uspje{nost lije~enja treba provjeriti i pratiti. Najpristupa~nije su kvantitativne serolo{ke metode, koje su brze, to~ne, relativno jeftine i jednostavne za izvo|enje, a za pacijente sigurne i prihvatljivije od invazivnih pretraga koje zahtijevaju gastroskopiju. Prednost ima imunoenzimsko odre|ivanje (ELISA) visine titra specifi~nih IgG-protutijela u serumu bolesnika. Svrha ovog istra`ivanja bila je pratiti i prikazati kretanje titra tih protutijela u bolesnika, koji su pri prvom pregledu bili seropozitivni, a nakon lije~enja eradikacija uzro~nika je uspjela. Prikazane su zna~ajke 90 lije~enih bolesnika, prosje~ne dobi 50 godina (16–79), od toga 52 s vrijedom dvanaesnika, 9 s vrijedom `eluca i 29 s gastritisom bez vrijeda. Serolo{ke pretrage ra|ene su imunoenzimskom tehnikom (ELISA), pomo}u Pyloriset EIA-G komercijalnog pripravka (Orion Diagnostica, Finland), po uputama proizvo|a~a. Po~etne vrijednosti titra kretale su se izme|u 280 i 11 875 (srednja vrijednost 2808 ), uz grani~ni titar 280 ±20. Nakon lije~enja, u svim kontrolnim uzorcima seruma, razine specifi~nih IgG protutijela postupno su padale za sve vrijeme pra}enja. Svi bolesnici ~iji po~etni titar nije prelazio 1200, tijekom godinu dana pra}enja postali su seronegativni. Srednji postotak pada titra anti-HP-IgG ispitivane populacije, bio je nakon dva mjeseca 56, nakon ~etiri mjeseca 68, nakon {est mjeseci 75, nakon godinu dana 87 (relativni titar bio je 13). Kao indikator uspje{nog lije~enja smatra se pad titra IgG najmanje za 40 % do ~etvrtog mjeseca po zavr{enoj terapiji, odnosno najmanje 50 % {est mjeseci nakon zadnje doze antibiotika.
Characterisation of ultra wideband body-centric radio channel dependency on angular and spatial variations

Variation in path loss models with respect to orientation of human body for both line-of-sight (LOS) and non-line-of-sight (NLOS) scenarios for ultra wideband off-body communication is experimentally and statistically investigated in this paper. Results show that for every 1° change in orientation angle between off-body transmitter and on-body receiver, path loss varies by almost 0.097 dB for LOS case and 0.12 dB for NLOS case.
A Novel And Efficient Algorithm To Enhance The Complexity Of Elliptic Curve Cryptography

In this paper, we propose a novel and efficient way to improve the computational complexity of the Elliptic Curve Cryptography [ECC] algorithm. ECC is a public key cryptography system, where the underlying calculations are performed over elliptic curves. The security of ECC is based on solving the Elliptic Curve Discrete Logarithm Problem [EDCLP]. We propose an algorithm to double the computational complexity of the conventional algorithm. The proposed algorithm generates two ECDLP opposed to one problem that was generated by the conventional algorithm being used till now. With the same key size, the proposed algorithm provides more security when compared to public key cryptography systems like RSA and ECC. It can be implemented efficiently in even less time when compared to ECC. The paper discuses the underlying protocol and proves how the enhancement in security and reduction in implementation time is achieved, thereby making it well suited for wireless communication.
Science at the Extremes?

2004 ANNUAL MEETINGSEATTLE, WASHINGTON-- A highly caffeinated crowd of about 11,000 attended this year's meeting here of the AAAS ( Science 's publisher). At one session, National Science Foundation Director Rita Colwell denied that the Bush Administration is "hostile to science" and suggested that the profession, and the writers who cover it, are to blame for the public's distorted view of scientific controversies.
Preventing pneumococcal bacteremia in patients at risk. Results of a matched case-control study.

BACKGROUND Three randomized controlled trials of the effectiveness of pneumococcal vaccine in elderly and chronically ill adults in the United States have failed to show significant protective efficacy during 44,213 person-years of follow-up. Case-control studies have greater statistical power to detect significant prevention of rare diseases such as pneumococcal bacteremia, but they also have a greater susceptibility to bias, necessitating consistent results from multiple studies. Three case-control studies at two different universities have shown prevention of systemic infection, but another study found no benefit. METHODS Patients with pneumococcal bacteremia who were at least 2 years old and had chronic illness indicating the need for pneumococcal vaccine, or who were at least 65 years old were compared with matched control subjects for frequency of prior vaccination. Matching variables included date of admission, age, sex, race, type and duration of chronic illness serving as the major vaccine indication, number of vaccine indications and number of medical hospitalizations since licensure of the pneumococcal vaccine in 1978, and type of primary medical care. RESULTS Pneumococcal vaccination was documented in the records of six (7%) of 85 cases and 26 (17%) of 152 control subjects, suggesting 81% efficacy in conditional logistical regression analysis (95% confidence interval, 34% to 94%, P = .008). CONCLUSIONS Four case-control studies at three universities have now demonstrated significant protective efficacy of pneumococcal vaccine for preventing pneumococcal bacteremia. The development of antibiotic-resistant Streptococcus pneumoniae indicates an urgent need for an increased rate of vaccination among high-risk patients and for the development of more immunogenic conjugate vaccines that may enhance efficacy among elderly and immunocompromised patients as well as infants.