Miracle-dz/UniFAR-FTUs huggingface dataset:
Urinary proteomics and molecular determinants of chronic kidney disease: possible link to proteases

Chronic kidney disease (CKD) is the gradual decrease in renal function. Currently available biomarkers are effective only in detecting late stage CKD. Biomarkers of early stage CKD and prognostic biomarkers are required. We review the major findings in urinary proteomics in CKD during the last five years. Significant progress has been made and today urinary proteomics is applied in large randomized trials, and in patient management. Many of the biomarkers indicate altered protease activity. We therefore also review the literature on proteases associated with renal function loss. We anticipate in silico prediction tools of protease activity and additional system biology studies may contribute to biomarker discovery and elucidate the role of proteases in CKD development and progression. These approaches will enable the deciphering of the molecular pathophysiology of CKD, and hence definition of the most appropriate therapeutic targets in the future. Together with stable biomarker panels available today, this will significantly improve patient management.
Online fine tuning of current PI controllers in spin-dry cycle of washing machines

A washing machine is a good example of a complex system. To meet market standards of the white goods industry the main driving motor of a washing machine must be chosen correctly and controlled effectively. High performance permanent magnet synchronous motors (PMSM) are now becoming the dominant electrical motor used in washing machines. In order to reach the desired efficiency level with PMSM type motors vector control scheme should be applied while cost and reliability requires no sensor to be used. This paper proposes an online method for tuning the proportional and integral terms of current controllers, which control the direct and quadrature axis currents in vector control of PMSM. The tuning is based on Nelder-Mead optimization algorithm and experimental results for spin-dry cycle are presented.
Odor Recognition Memory in Humans: Role of Right Temporal and Orbitofrontal Regions

Odor memory was studied in 121 patients with unilateral cerebral excision from temporal, frontal, frontotemporal, or centroparietal areas, and 20 control subjects. Odors were presented birhinally, and half were named, to examine the effect of verbal labelling. Testing was by yes-no recognition immediately after presentation, 20 min later, and after 24 hr, using eight different targets and eight new foils each time. The results showed impairment only after excision from the right temporal or right orbitofrontal cortex. All groups showed significant forgetting over time, and verbalized odors were recognized more efficiently than unlabelled ones. The findings, suggesting a right hemisphere predominance in odor memory, support similar results for odor discrimination.
IDENTITY DISCLOSURE PROTECTION IN DYNAMIC NETWORKS USING K W - STRUCTURAL DIVERSITY ANONYMITY

The data mining figures out accurate information for requesting user after the raw data is analyzed. Among lots of developments, data mining face hot issues on security, privacy and integrity. Data mining use one of the latest technique called privacy preserving data publishing (PPDP), which enforces security for the digital information provided by governments, corporations, companies and individuals in social networks. People become embarrassed when adversary tries to know the sensitive information shared. Sensitive information is gathered through the vertex and multi community identities of the user. Vertex identity denotes the self-information of user like name, address, mobile number, etc. Multi community identity denotes the community group in which the user participates. To prevent such identity disclosures, this paper proposes K W -structural diversity anonymity technique, for the protection of vertex and multi community identity disclosure. In K W -structural diversity anonymity technique, k is privacy level applied for users and W is an adversary monitoring time.
Frequent mutation of the p53 gene in human esophageal cancer.

Sequence alterations in the p53 gene have been detected in human tumors of the brain, breast, lung, and colon, and it has been proposed that p53 mutations spanning a major portion of the coding region inactivate the tumor suppressor function of this gene. To our knowledge, neither transforming mutations in oncogenes nor mutations in tumor suppressor genes have been reported in human esophageal tumors. We examined four human esophageal carcinoma cell lines and 14 human esophageal squamous cell carcinomas by polymerase chain reaction amplification and direct sequencing for the presence of p53 mutations in exons 5, 6, 7, 8, and 9. Two cell lines and five of the tumor specimens contained a mutated allele (one frameshift and six missense mutations). All missense mutations detected occurred at G.C base pairs in codons at or adjacent to mutations previously reported in other cancers. The identification of aberrant p53 gene alleles in one-third of the tumors we tested suggests that mutations at this locus are common genetic events in the pathogenesis of squamous cell carcinomas of the esophagus.
The Reduction of Allograft Arteriosclerosis in Intestinal Transplant Is Associated With Sphingosine Kinase 1/Sphingosine-1-Phosphate Signaling After Fish Oil Treatment

Background Transplant arteriosclerosis is a major cause of late intestinal allograft dysfunction. However, little is known about the immunologic and molecular mechanisms underlying it, and no effective treatment is available. This study aimed to investigate the role of sphingosine kinase 1 (SPHK1)/sphingosine-1-phosphate (S1P) in transplant arteriosclerosis and find out whether fish oil (FO) attenuates allograft arteriosclerosis through S1P signaling. Methods A rat model with orthotopic intestinal transplantation was conducted in this study. Animals received daily FO supplementation after intestinal transplant. The allogeneic recipients by phosphate-buffered saline or corn oil treatment served as controls. The allograft arteriosclerosis was characterized, and the expression of SPHK1 and S1P receptors (S1P1, S1P2, and S1P3) was determined on day 190 posttransplant. Results The allogeneic controls presented transplant vasculopathy in mesenteric vessels, including intimal thickening, fibrosis, and leukocyte infiltration. The transplant arteriosclerosis was markedly reduced in FO-fed animals. The pression of SPHK1 and its activity were significantly augmented, and the expression of S1P1 and S1P3 messenger RNA was up-regulated in the allogeneic controls. FO supplementation suppressed the activation of SPHK1 and led to a decrease in the expression of S1P1 and S1P3 in these tissues in transplant arteriosclerosis. Conclusions These results demonstrate that the activation of SPHK1/S1P signaling plays a possible role in the pathogenesis of transplant arteriosclerosis. The reduction of allograft arteriosclerosis by FO may be associated with down-regulation of SPHK1/S1P signaling. Understanding the role of FO for SPHK1/S1P may help us to identify considerable therapeutic targets for transplant arteriosclerosis.
Discovery of topic based on mass incidents and research of user roles

Based on the analysis of user behavior in social network, knowledge is introduced into social subject's behavior and explores the online social network public opinion research in the related method. First of all, based on the multi-dimensional social relationship between the users participating subject discussion, two-layer overlay network model of topic keywords with the user based on implicit link is put forward targeting at the problem of short text and semantic sparse in a new generation of online social network represented by Weibo system. The model takes the user as the center, the keyword as the basic unit, and applies the clustering method. The model can be used on the real data sets to show that all kinds of important users and user groups of the hot topics, and discuss different users and user group of the topics of concern in the form of a keyword to. It is found that the same role in different groups of users have different motives in the real social network. These findings have important practical significance for discovery and control of public opinion in the social network systems.
Five-level converter with selective harmonic elimination for STATCOM

In this paper, five-level Static Synchronous Compensator (STATCOM) is analyzed with reduced number of power switches. The simulation has been performed by using a digital signal processing unit (DSP) and Matlab/Simulink together. Selective harmonic elimination, single phase real (P) and reactive (Q) power methods are used to control power flow in the delta connected converter. The response of STATCOM is investigated under inductive loading conditions. All the control algorithm is programmed on DSP and grid connected AC/DC converter is simulated in Matlab/Simulink. The predicted results from Matlab and DSP TMS320F28335 have been presented.
Impact of disturbance method on parameter identification of photovoltaic inverter model

With large scale grid-connected photovoltaic (PV) generation, it plays a more and more important role in power system, while the investigation of PV integration problem and solution is based on accurate model parameters. In this paper, the inverter model is introduced and model parameter sensitivity is analysed under different disturbances. Then the impact of disturbance method on parameter identification of PV inverter is discussed. Three disturbance cases are simulated to provide data for identification, and the identification results from these cases are compared. The analysis conclusion is useful for experimental design. Finally, the parameters of an actual inverter are identified based on experimental data.
Overview and Categorization of Robots Supporting Independent Living of Elderly People: What Activities Do They Support and How Far Have They Developed

Over the past decades, many robots for the elderly have been developed, supporting different activities of elderly people. A systematic review in four scientific literature databases and a search in article references and European projects was performed in order to create an overview of robots supporting independent living of elderly people. The robots found were categorized based on their development stage, the activity domains they claim to support, and the type of support provided (i.e., physical, non-physical, and/or non-specified). In total, 107 robots for the elderly were identified. Six robots were still in a concept phase, 95 in a development phase, and six of these robots were commercially available. These robots claimed to provide support related to four activity domains: mobility, self-care, interpersonal interaction & relationships, and other activities. Of the many robots developed, only a small percentage is commercially available. Technical ambitions seem to be guiding robot development. To prolong independent living, the step towards physical support is inevitable and needs to be taken. However, it will be a long time before a robot will be capable of supporting multiple activities in a physical manner in the home of an elderly person in order to enhance their independent living.
Reproductive character displacement of female mate preferences for male cuticular hydrocarbons in Drosophila subquinaria

Several lines of evidence implicate sexual isolation in both initiating and completing the speciation process. Although its existence is straightforward to demonstrate, understanding the evolution of sexual isolation requires identifying the underlying phenotypes responsible so that we can determine how these have diverged. Here, we study geographic variation in female mate preferences for male sexual displays in the fly Drosophila subquinaria. Female D. subquinaria that are sympatric with its sister species D. recens discriminate strongly against both D. recens and allopatric conspecific males, whereas females from allopatric populations do not. Furthermore, female mate preferences target at least in part a suite of cuticular hydrocarbons (CHCs) in males and geographic variation in CHCs mirrors the pattern of mate discrimination. In this study, we quantify female mate preferences for male CHCs from populations that span the geographic range of D. subquinaria. We find that the direction of linear sexual selection varies significantly between populations that are sympatric versus allopatric with D. recens in a pattern of reproductive character displacement. Differences in preference partially align with existing differences in CHCs and patterns of sexual isolation, although discrepancies remain that suggest the involvement of additional traits and/or more complex, nonlinear preference functions.
Total respiratory input impedance with the upper airway wall shunt minimized.

Respiratory impedances (Zrs) measured with the cheeks manually supported (Zsc) demonstrate an antiresonance (AR) at approximately 170 Hz, whereas those measured with the head generator (Zhg) have an AR at significantly lower frequencies (150 Hz). The differences in the AR between methods were previously attributed to upper airway wall (UAW) shunting in Zsc, and Zhg was believed to represent shunt-free impedance. To test this hypothesis, we measured four independent estimates of Zrs (4-256 Hz) in five healthy adults. Applying the oscillations at the mouth, we measured Zrs with the cheeks unsupported (Zuc) and when the subject's head and neck were enclosed in a rigid chamber completely filled with water (Zwa). We also measured Zhg with the oscillations applied around the head. Because water is incompressible, Zwa should minimize UAW shunt if not completely eliminate it. There were no significant differences in any of the AR features (e.g., location and bandwidth) of Zuc, Zsc, and Zwa. Conversely, all AR features of Zwa and Zhg were significantly different. To assess wall motion during both forms of oscillations (i.e., applied at the mouth and around the head), we measured two UAW local impedances by use of accelerometers placed on the cheeks (Zch) and submental (Zsm) region. Above 40 Hz, Zch and Zsm estimates were significantly dependent on the forcing method. Furthermore, Zch and Zsm made with the standard oscillations were consistent with the lumped UAW impedances measured with a head plethysmograph, whereas those made with the oscillations around the head were not. Therefore we conclude that, at > 32 Hz, Zsc more closely represents shunt-free impedance than does Zhg and hence should be preferred when Zrs are measured.
Influence of Cigarette Smoking on the Changes Produced by‐Spinal Anesthesia on Expiratory Forced Volumes and Flow Rates

Since subarachnoid block is frequently the anesthetic of choice in patients with lung disease, we undertook a study in patients undergoing a variety of surgical procedures, comparing the changes produced by spinal anesthesia on expiratory forced volumes and flow rates in patients with varied smoking histories. In addition, a correlation of these results with the height of sensory blockade was made. METHOD Twenty-five patients, 14 men and 11 women between 24 and 64 years old, were premedicated with 1 to 2 ml. of Innovare and 0.01 mg. /kg. of atropine sulfate intramuscularly at least 45 minutes before initial determination of expiratory forced volumes and flow rates. A vitalograph apparatus was
Characterization and Functional Expression of cDNAs Encoding Methionine-sensitive and -insensitive Homocysteine S-Methyltransferases from Arabidopsis *

Plants synthesize S-methylmethionine (SMM) from S-adenosylmethionine (AdoMet), and methionine (Met) by a unique reaction and, like other organisms, use SMM as a methyl donor for Met synthesis from homocysteine (Hcy). These reactions comprise the SMM cycle. Two Arabidopsis cDNAs specifying enzymes that mediate the SMM → Met reaction (SMM:HcyS-methyltransferase, HMT) were identified by homology and authenticated by complementing an Escherichia coli yagDmutant and by detecting HMT activity in complemented cells. Gel blot analyses indicate that these enzymes, AtHMT-1 and -2, are encoded by single copy genes. The deduced polypeptides are similar in size (36 kDa), share a zinc-binding motif, lack obvious targeting sequences, and are 55% identical to each other. The recombinant enzymes exist as monomers. AtHMT-1 and -2 both utilize l-SMM or (S,S)-AdoMet as a methyl donor in vitro and have higher affinities for SMM. Both enzymes also use either methyl donor in vivo because both restore the ability to utilize AdoMet or SMM to a yeast HMT mutant. However, AtHMT-1 is strongly inhibited by Met, whereas AtHMT-2 is not, a difference that could be crucial to the control of flux through the HMT reaction and the SMM cycle. Plant HMT is known to transfer the pro-R methyl group of SMM. This enabled us to use recombinant AtHMT-1 to establish that the other enzyme of the SMM cycle, AdoMet:MetS-methyltransferase, introduces the pro-Smethyl group. These opposing stereoselectivities suggest a way to measure in vivo flux through the SMM cycle.
Platelet-derived growth factor increases the in vivo activity of phospholipase C-gamma 1 and phospholipase C-gamma 2

Upon binding to its cell surface receptor, platelet-derived growth factor (PDGF) causes the tyrosine phosphorylation of phospholipase C-gamma 1 (PLC-gamma 1) and stimulates the production of diacylglycerol and inositol 1,4,5-triphosphate. We showed that following stimulation by PDGF, rat-2 cells overexpressing PLC-gamma 1 display an increase in the levels of both tyrosine-phosphorylated PLC-gamma 1 and inositol phosphates compared with the parental rat-2 cells. This increased responsiveness to PDGF is a direct effect of PLC-gamma 1 overexpression, as a cell line expressing similar levels of an enzymatically inactive point mutant of PLC-gamma 1, PLC-gamma 1 335Q, did not show elevated inositol phosphate production in response to PDGF. Hematopoietic cells express PLC-gamma 2, a PLC isoform that is closely related to PLC-gamma 1. When rat-2 cells overexpressing PLC-gamma 2 were treated with PDGF, an increase in both the tyrosine phosphorylation and the in vivo activity of PLC-gamma 2 was observed. Aluminum fluoride (AIF4-), a universal activator of PLC linked to G-proteins, did not produce an increase in the levels of inositol phosphates in either of the overexpressing cell lines compared with parental rat-2 cells, demonstrating that PLC-gamma isoforms respond specifically to a receptor with tyrosine kinase activity.
Estimation of power system dominant modes

The aim of this paper is to propose an approach to estimate the nature (damping and frequency) of a dominant mode. The suggested method, based on Prony analysis, aims to directly evaluate dominant modes of electromechanical oscillations. The basic idea is to fit the given oscillation with a fitting function having one mode only whose parameters need to be identified by any identification process. When the transient of the given signal vanishes, modes having high damping attenuate reaching a quasi linear behavior and revealing the dominant mode only. In this sense, the fitting function gains characteristic parameters (damping and frequency) of the dominant mode. For the identification process we suggest a nonlinear analysis approach based on the Lyapunov method applied to the Sensitivity theory. The proposed methodology is tested on the New England 39-bus system.
Induction of Oxidative Metabolism by Mitochondrial Frataxin Inhibits Cancer Growth

More than 80 years ago Otto Warburg suggested that cancer might be caused by a decrease in mitochondrial energy metabolism paralleled by an increase in glycolytic flux. In later years, it was shown that cancer cells exhibit multiple alterations in mitochondrial content, structure, function, and activity. We have stably overexpressed the Friedreich ataxia-associated protein frataxin in several colon cancer cell lines. These cells have increased oxidative metabolism, as shown by concurrent increases in aconitase activity, mitochondrial membrane potential, cellular respiration, and ATP content. Consistent with Warburg's hypothesis, we found that frataxin-overexpressing cells also have decreased growth rates and increased population doubling times, show inhibited colony formation capacity in soft agar assays, and exhibit a reduced capacity for tumor formation when injected into nude mice. Furthermore, overexpression of frataxin leads to an increased phosphorylation of the tumor suppressor p38 mitogen-activated protein kinase, as well as decreased phosphorylation of extracellular signal-regulated kinase. Taken together, these results support the view that an increase in oxidative metabolism induced by mitochondrial frataxin may inhibit cancer growth in mammals.
Active control for flutter suppression: an experimental investigation

This paper describes an experimental study involving the implementation of the method of receptances to control binary flutter in a wind-tunnel aerofoil rig. The aerofoil and its suspension were designed as part of the project. The advantage of the receptance method over conventional state-space approaches is that it is based entirely on frequency response function measurements, so that there is no need to know or to evaluate the system matrices describing structural mass, aeroelastic and structural damping and aeroelastic and structural stiffness. There is no need for model reduction or the estimation of unmeasured states, for example by the use of an observer. It is demonstrated experimentally that a significant increase in the flutter margin can be achieved by separating the frequencies of the heave and pitch modes. Preliminary results from a complementary numerical programme using a reduced-order model, based on linear unsteady aerodynamics, are also presented
The monocular model-based 3D pose tracking

Image acquisition devices can usually only get two-dimensional plane images. It has always been research focus in the field of computer vision that how to quickly and accurately recover motion parameters of objects in space from two-dimensional plane images. In this paper, the 3D pose tracking algorithm of monocular model-based is studied. This paper firstly uses the technology of binocular stereo vision to achieve Three-dimensional reconstruction of the objects and uses a two-step method based on the reweighted brightness depth change constraint equation to solve pose on the frame. The paper adopts the brightness change constraint equation to get the coarse value of 3D pose, and then proposes the reweighted brightness depth method based on Huber function to get the exact value of 3D pose. The paper also presents the multi-frame registration method of view to solve the registration failure problem and eliminate the accumulated error. Experiments results prove a great advantage of real-time and accuracy compared with other systems.