Miracle-dz/UniFAR-FTUs huggingface dataset:
A systematic mapping of test case generation techniques using UML interaction diagrams

Model‐based test case generation techniques provide a mechanism to derive tests systematically. This study provides a systematic mapping of test case generation techniques based on UML interaction diagrams. The study compares the test case generation techniques regarding their capabilities and limitations, and it also assesses the reporting quality of the primary studies. We can conclude that the studies presenting test case generation techniques using UML interaction diagrams were not following the guidelines for research methods (eg, case studies or experiments). Solutions were not empirically evaluated in industrial contexts. Our study revealed that better tool support is needed to introduce the UML interaction diagram–based test case generation techniques in the industry.
A INFLUÊNCIA DA ESTRUTURA ORGANIZACIONAL NO PROCESSO DE FORMULAÇÃO E IMPLEMENTAÇÃO DO PLANEJAMENTO ESTRATÉGICO NA PMMG.

Este artigo tem o objetivo de avaliar como o fator estrutura orgânica influencia no processo de formulacao e implementacao do processo de Planejamento Estrategico, atraves do estudo de caso na realidade da P olicia Militar de Minas Gerais (PMMG) . A instituicao foi escolhida, principalmente por viven ciar o processo de implementacao do planejamento estrategico e possuir uma estrutura organizacional formalizada. Para elucidar o problema de pesquisa foi utilizado como ferramenta a entrevista semi - estruturada em profundidade, analisadas de forma qualitativa. A implementacao do planejamento estrategico pode ser considerada um desafio para muitas organizacoes e o caso da PMMG nao se difere desta realidade, entretanto, os dados demonstram que a integracao entre o planejamento estrategico e a estrutura organizacional tende a promover a implementacao das estrategias. Isto porque o resultado deste estudo indica que as fases do planejamento estrategico influenciam e sao influenciadas pelos elementos da estrutura organizacional.
Connections Between Nuclear Physics and the Origin of Life - Examining the Origin of Biomolecular Chirality

The discovery of bio-molecules in meteorites with an excess of one chiral state has created one of the biggest questions in astrobiology today. That is, what is the origin of bio-molecular homochirality? Studies of this question are highly interdisciplinary, and while several phenomenological models exist, we examine the relationship between fundamental symmetries at the particle level and the macroscopic formation of bio-molecules. A model has been developed which couples fundamental interactions with the formation of molecular chirality. In this magneto-chiral model atomic nuclei bound in amino acids interact via the weak interaction in stellar environments. Nuclei are coupled to the molecular geometry (chirality) via the shielding tensor, the same interaction responsible for NMR identification. Associated with this is the fact that isotopic abundances vary from solar system values. Interactions with leptons can selectively destroy one chiral state over the other while changing isotopic values. Possible sites are proposed in which this model may exist.
Endovascular reconstruction of primary coarctation in a 12-year-old boy technical consideration

Coarctation is a generalized disease which mainly manifests in aorta and presents as aortic coarctation. While transcatheter approaches have replaced surgery, there is still no consensus about the best among only balloon dilatation, aortic stent-grafts, self-expanding stent or balloon expandable stent. Here, we report a case of 12-year-old boy who presented with hypertension in whom severe primary coarctation of thoracic aorta was diagnosed which was successfully treated with endovascular reconstruction using self-expandable stent. Stent migration is always an issue during deployment and which is minimized with rapid pacing and bringing down the blood pressure. We successfully performed the endovascular treatment without aid of pacing thereby bringing his blood pressure to near normal level with no further catch up on follow up. Therefore, balloon expandable sten
Parallel unstructured mesh adaptation using iterative remeshing and repartitioning

Mesh adaptation has proven to be a powerful tool for increasing the accuracy ofnumerical simulations whenever the solution exhibits strong non-uniform features over the com-putational domain. Sequential remeshing currently represents a bottleneck for parallel solvers. Tothis aim, we present a parallel remeshing algorithm that enables the reuse of existing sequential remeshing libraries, a non-intrusive linkage with third-party solvers, and an efficient exploitationof distributed parallel environments. The numerical procedure is implemented in the open sourceParMmg software package.
Zum Gesundheitszustand Hochschulbeschäftigter im Altersgang am Beispiel aerober Ausdauerleistungsfähigkeit und der Einfluss sportlicher Aktivität

Zusammenfassung Neben dem natürlichen Alterungsprozess ist insbesondere die körperliche Inaktivität für die Abnahme der Ausdauerleistungsfähigkeit im Altersgang verantwortlich zu machen. Das Ziel der vorliegenden Untersuchung besteht zunächst in der Einschätzung der Ausdauerleistungsfähigkeit Hochschulbeschäftigter. Hierfür erfolgt anschließend der Vergleich sportlich aktiver (≥ 2 Stunden Sport / Woche) und inaktiver (< 2 Stunden Sport / Woche) Personen. Die retrospektiv durchgeführte Untersuchung an 218 Rostocker Hochschulbeschäftigten zeigt für die Gesamtstichprobe eine im IPN-Test erhobene leicht überdurchschnittliche Ausdauerleistungsfähigkeit. Beginnend mit dem mittleren Erwachsenenalter nimmt diese unabhängig vom Sporttyp deutlich ab (p < 0,05). In den Altersgruppen der 30–44-Jährigen und der 45–60-Jährigen weisen sportlich Aktive wesentlich bessere Werte als sportlich Inaktive auf (p < 0,05). Die Ergebnisse zeigen außerdem, dass Aktive 45–60-Jährige eine annähernd vergleichbare Ausdauerleistungsfähigkeit wie die Inaktiven 30–40-Jährigen erreichen. Der altersbedingte Rückgang ab dem mittleren Lebensalter kann nicht gänzlich aufgehalten, aber über sportliche Aktivität um zumindest eine Altersklasse erhalten und deutlich begünstigt werden. Unter Nutzung der vorliegenden Ergebnisse kann die Organisation und Bewertung von Interventionen zur Gesundheitsförderung im Hochschulwesen gezielter erfolgen.
Study on blood gases, Acid-Base balance and the therapeutic evaluation of different protocol of treatment of mastitic cows.

This study was planned to reveal the changes in blood gases and acid-base values in mastitic cows and to state the intravenous fluid therapy regimen treatment. A herd with a population of 150 lactating cows was screened for clinical and subclinical mastitis for a period of 6 months. Based on inclusion and exclusion criteria, twenty-eight cows with clinical mastitis were divided in three groups (mastitic not treated (group M), mastitic treated with antibiotic only (group TA) and mastitic treated with antibiotic and fluid therapy (group TAF) and another five healthy cows (group C) served as controls. Blood gases, SCC, CMT scores, udder health status and cure rate were carefully investigated. There was significant differences between PO2, PCO2, BE, and HCO3 concentration in mastitic cows. Increased pH, BE, and HCO3 referred to metabolic alkalosis whereas increased PCO2 indicate compensatory respiratory acidosis. The results of SCC in milk agreed to CMT scores, and to some extent to udder health status among the entire period of study. Cure rate was earlier in group TAF with less number of treatment than in group TA. It has been concluded from this study that administration of fluid therapy might be useful as an adjunct in case of clinical mastitis in cows to get quick clinical recovery with less number of treatments. However, the role of blood gases and acid – base status in mastitis should be investigated in details.
Flood Risk Literacy: Communication and Implications for Protective Action

Flooding is among the costliest natural disasters in the United States. Research indicates that flood risk perceptions and knowledge often shape flood-related decision making; however, relatively less is known about specific individual differences in flood risk literacy. The current study presents data from 630 participants who completed a flood risk communication experiment and a general decision-making inventory (e.g., numeracy, risk perceptions, knowledge). Structural equation modeling revealed that both numeracy and flood knowledge partially explain differences in vulnerability, including effects on risk comprehension, weather risk perceptions, and decision quality (i.e., taking protective action). Limitations and implications for enhancing flood risk literacy are discussed.
Classification of 3D Film Patterns with Deep Learning

Researches on pattern recognition have been tremendously performed in various fields because of its wide use in both machines and human beings. Previously, traditional methods used to study pattern recognition problems were not strong enough to recognize patterns accurately as compared to optimization algorithms. In this study, we employ both traditional based methods to detect the edges of each pattern in an image and apply convolutional neural networks to classify the right and wrong pattern of the cropped part of an image from the raw image. The results indicate that edge detection methods were not able to detect clearly the patterns due to low quality of the raw image while CNN was able to classify the patterns at an accuracy of 84% within 1.5 s for 10 epochs.
ASSOCIATION OF THE METABOLIC SYNDROME AND VITAMIN D RECEPTOR GENE POLYMORPHISMS: A CROSS SECTIONAL STUDY

The Vitamin D Receptor gene (VDR) expressed in many tissues and are able to modulate the expression of several other genes. The purpose of this study was to assess the association between the metabolic syndrome (MetSyn) and the presence of VDR genes ApaI, BsmI, TaqI and FokI polymorphisms as well as serum levels of vitamin D. Total eighty two (82) individuals were assessed in a cross-sectional study. Enzymatic digestion method was used to detect the VDR polymorphisms and established by allele specific PCR or amplification of refractory mutation. MetSyn was classified based on the National Cholesterol Education Program – Adult Treatment Panel III Assessment of the association of VDR, as well as serum vitamin D level, with MetSyn components was also evaluated. Serum vitamin D levels were significantly low (p < 0.01) in MetSyn patients. The occurrence of the genotypes in Apal was significantly different as compared to individuals with MetSyn and the control group (P <0.05). A negative correlation was reported between MetSyn and 25(OH) vitamin D levels, type-2 diabetes and glucose homeostasis. Further, as compared to individuals without MetSyn, subjects with MetSyn who carry AA genotype had higher waist circumference and BMI. Serum Vitamin D level was also inversely associated with waist circumference (P < 0.001), triglycerides (P < 0.01), haemoglobin A1c (P < 0.01), * Corresponding author KEYWORDS
Новые взгляды на понятие «пребиотики» и их влияние на организм ребенка // Reconsidered Concept of «Prebiotics» and Their Impact on the Child’s Organism

Detection of a large number of oligosaccharides in breast milk predetermined their use in the composition of infant formula. The most studied prebiotic simulating the unique properties of breast milk oligosaccharides is the scGOS/lcFOS mixture. Its efficacy is confirmed in clinical studies. In 2017, the experts of the International Scientific Association of Probiotics and Prebiotics (ISAPP) adopted a new definition for «prebiotics», which greatly expanded the concept of their application. The World Allergy Organization (WAO) recommends the use of prebiotics in allergy- prone children. The guidelines are based on the results of studies of the influence of prebiotics on the intestinal microbi, a violation of the composition and functions of which predisposes to the development of allergy. Currently, the search for more promising technologies for the production of prebiotics continues. Обнаружение большого количества олигосахаридов в грудном молоке предопределило их использование в составе детских молочных смесей. Наиболее изученным пребиотиком, имитирующим уникальные свойства олигосахаридов грудного молока, является комплекс scGOS/lcFOS. Его эффективность подтверждена в клинических исследованиях. В 2017 г. эксперты Международной научной ассоциации пробиотиков и пребиотиков (ISAPP) приняли новое определение понятия «пребиотики», что значительно расширило концепцию их использования. Всемирная организация по аллергии рекомендует использовать пребиотики у детей с повышенным риском развития аллергии. Рекомендации основаны на результатах исследований влияния пребиотиков на микробиом кишечника, нарушение состава и функций которого предрасполагает к развитию аллергии. В настоящее время продолжается поиск более перспективных технологий по производству пребиотиков.
eCommons@AKU eCommons@AKU

Introduction: Monitoring vital signs is a basic indicator of a patient’s health status and allows prompt detection of delayed recovery or adverse effects and early intervention. Patients with adverse events during hospitalization often display clinical decline for several hours before the event is observed. Non-critical care Nurses’ inconsistent recognition and response to patient deterioration lead to an increase in the length of hospital stay, unexpected admissions to the ICU, and increased morbidity and mortality. Aim: The study aimed to assess the factors that facilitate or impede the detection of early warning signs among adult patients hospitalized in tertiary care settings. Training should be provided to improve nurses’ knowledge, practice and attitude toward early warning signs of deteriorating patients leading to enhanced clinical judgment, skills and decision-making in addressing alerts. Methodology: A literature search was carried out in various databases; these were Cumulative Index to Nursing and Allied Health Literature (CINHAL), Google Scholar, PubMed, Science Direct, and Sage. The search area was narrowed from 2017 to 2022. The keywords used were “prevalence” AND “un-planned ICU admission”, “the importance of early warning signs” “outcome failure in rescue” “patient deterioration, communication” “improvement in early detection” AND “patient outcome admission” AND “early warning signs” AND “Pakistan”. After the analysis process, around 33 articles that met the inclusion criteria and were most relevant to the scope and context of the current study were considered. Conclusion: Most of the studies had reviewed literature in a qualitative retrospective observational study, content analysis, mixed method, and quasi-experimental study. The
The value and opportunity of restoring Australia's lost rock oyster reefs

Recognizing the historical loss of habitats and the value and opportunities for their recovery is essential for mobilizing habitat restoration as a solution for managing ecosystem function. Just 200 years ago, Sydney rock oysters (Saccostrea glomerata) formed extensive reef ecosystems along Australia's temperate east coast, but a century of intensive harvest and coastal change now confines S. glomerata to encrusting the hard‐intertidal surfaces of sheltered coastal waters. Despite the lack of natural reef recovery, there appears enormous potential for the restoration of intertidal S. glomerata ecosystems across Australia's east coast, with large anticipated benefits to water quality, shoreline protection, and coastal productivity. Yet, no subtidal reefs remain and the potential for subtidal restoration is a critical knowledge gap. Here, we synthesize historical, ecological, and aquaculture literature to describe a reference system for the traits of S. glomerata reefs to inform restoration targets, and outline the barriers to, and opportunities and methods for, their restoration. These reefs support extremely biodiverse and productive communities and can ameliorate the environmental stress experienced by associated communities. Rock oyster restoration, therefore, provides an ecosystem‐based strategy for assisting the adaptation of marine biodiversity to a changing climate and intensive human encroachment. Though an estimated 92% of S. glomerata ecosystems are lost, there remains great potential to restore these valuable and resilient ecosystems.
Distribution of genetic diversity reveals colonization and philopatry of the loggerhead sea turtles across geographic scales

Aim Understanding the processes that underlie the distribution of genetic diversity in endangered species is a goal of modern conservation biology. Specifically, how population structure affects genetic diversity and contributes to a species’ adaptive potential remain elusive. The loggerhead sea turtle (Caretta caretta) faces multiple conservation challenges due to its migratory nature and philopatric behaviour. Locations Atlantic Ocean, Cabo Verde, island of Boavista Methods Here, using 4207 mtDNA sequences, we analysed the colonisation patterns and distribution of genetic diversity within a major ocean basin (the Atlantic), a regional rookery (Cabo Verde Archipelago) and a local island (Island of Boavista, Cabo Verde). Results Hypothesis-driven population genetic models suggest the colonization of the Atlantic has occurred in two distinct waves, each corresponding to major mtDNA lineages. We propose the oldest lineage entered the basin via the isthmus of Panama and sequentially established aggregations in Brazil, Cabo Verde and in the area of USA and Mexico. The second lineage entered the Atlantic via the Cape of Good Hope, establishing colonies in the Mediterranean Sea, and from then on, re-colonized the already existing rookeries of the Atlantic. At the Cabo Verde level, we reveal an asymmetric gene flow maintaining links across nesting groups despite significant genetic structure amongst nesting groups. This structure stems from female philopatric behaviour which could further be detected by weak but significant structure amongst beaches separated by only a few kilometres on the island of Boavista. Main conclusion To explore demographic processes at diverse geographic scales improves understanding the complex evolutionary history of highly migratory philopatric species. Unveiling the past facilitates the design of conservation programmes targeting the right management scale to maintain a species’ adaptive potential and putative response to human-induced selection.
Relaciones ecológicas entre pecaríes de collar y cerdos asilvestrados en el sur de México: ¿evidencia de la división de nicho?

Se ha registrado la presencia de pecaries de collar ( Pecari tajacu ) y cerdos asilvestrados ( Sus scrofa ) en el suroeste de Campeche. A pesar de esta coexistencia, la division de nicho entre estas especies no habia sido estudiada en Mexico. Los objetivos de este trabajo fueron: evaluar el uso y seleccion de habitat, identificar variables que determinan la presencia de ambas especies; asi como analizar el patron de actividad de pecaries de collar en presencia y ausencia de cerdos asilvestrados. Se recolectaron registros directos e indirectos mediante camaras-trampa y transectos, entre enero y junio de 2018. Se obtuvo un alto grado de traslape en el uso de habitat entre especies, sin embargo, a escala mas fina, los pecaries seleccionaron areas de selva baja inundable y los cerdos seleccionaron cultivos de palma de aceite y popales/tulares. Las variables antropicas influyeron positivamente en la presencia de los cerdos y negativamente en la de los pecaries. Los patrones de actividad de pecaries se alteraron en presencia de los cerdos. Es posible que en la region de laguna de Terminos, donde la configuracion del paisaje compuesta por areas altamente antropizadas y ligadas a fragmentos conservados, se este permitiendo la distribucion de recursos, y por consiguiente, la segregacion espacio-temporal de ambas especies.
Fog computing task scheduling optimization based on multi-objective simplified swarm optimization

With the dramatic growth of data volume, the cloud computing structure has faced a severe difficulty, the latency. To deal with this problem, researchers have proposed the fog computing structure, which can successfully release the computation loads from one datacenter of cloud to multiple local fog devices. Hence, the tasks will be processed at the local fog device and avoid transmitting to datacenter which is not cost-effective, and the results can be transmitted to the users immediately. The main differences of task scheduling between cloud computing and fog computing are the processors specifications, such as processing rate, cost per unit time. The processing rate of processors in datacenter is fast but the cost per unit time is costly. However, the processing rate of fog devices is not as fast as datacenter but it is relatively cost-effective. Consequently, we are facing a multi-objective optimization problem. Hence, we adopted an elite MOSSO (Multi-Objective Simplified Swarm Optimization) with considering the characteristics of fog computing paradigm.
Subtype-specific epigenomic landscape and 3D genome structure in bladder cancer

Muscle-invasive bladder cancers have recently been characterized by their distinct expression of luminal and basal genes, which could be used to predict key clinical features such as disease progression and overall survival. For example, FOXA1, GATA3, and PPARG have been shown to be essential for luminal subtype-specific regulation and subtype switching, while TP63 and STAT3 are critical for basal subtype bladder cancer. Despite these advances, the underlying epigenetic mechanism and 3D chromatin architecture for subtype-specific regulation in bladder cancers remains largely unknown. Here, we determined the genome-wide transcriptome, enhancer landscape, TF binding profiles (FOXA1 and GATA3) in luminal and basal subtypes of bladder cancers. Furthermore, we mapped genome-wide chromatin interactions by Hi-C in both bladder cancer cell lines and primary patient tumors, for the first time in bladder cancer. We showed that subtype-specific transcription is accompanied by specific open chromatin and epigenomic marks, at least partially driven by distinct TF binding at distal-enhancers of luminal and basal bladder cancers. Finally, we identified a novel clinically relevant transcriptional factor, Neuronal PAS Domain Protein 2 (NPAS2), in luminal bladder cancers that regulates other luminal-specific genes (such as FOXA1, GATA3, and PPARG) and affects cancer cell proliferation and migration. In summary, our work shows a subtype-specific epigenomic and 3D genome structure in urinary bladder cancers and suggested a novel link between the circadian TF NPAS2 and a clinical bladder cancer subtype.