Miracle-dz/UniFAR-FTUs huggingface dataset:
Believe The HiPe: Hierarchical Perturbation for Fast and Robust Explanation of Black Box Models

Understanding the predictions made by Artiﬁcial Intelligence (AI) systems is becoming more and more important as deep learning models are used for increasingly complex and high–stakes tasks. Saliency mapping – an easily interpretable visual attribution method – is one important tool for this, but existing formulations are limited by either computational cost or architectural constraints. We therefore propose Hierarchical Perturbation, a very fast and completely model-agnostic method for explaining model predictions with robust saliency maps. Using standard benchmarks and datasets, we show that our saliency maps are of competitive or superior quality to those generated by existing black-box methods – and are over 20 × faster to compute.
Repairing serializability bugs in distributed database programs via automated schema refactoring

Serializability is a well-understood concurrency control mechanism that eases reasoning about highly-concurrent database programs. Unfortunately, enforcing serializability has a high performance cost, especially on geographically distributed database clusters. Consequently, many databases allow programmers to choose when a transaction must be executed under serializability, with the expectation that transactions would only be so marked when necessary to avoid serious concurrency bugs. However, this is a significant burden to impose on developers, requiring them to (a) reason about subtle concurrent interactions among potentially interfering transactions, (b) determine when such interactions would violate desired invariants, and (c) then identify the minimum number of transactions whose executions should be serialized to prevent these violations. To mitigate this burden, this paper presents a sound fully-automated schema refactoring procedure that refactors a program’s data layout – rather than its concurrency control logic – to eliminate statically identified concurrency bugs, allowing more transactions to be safely executed under weaker and more performant database guarantees. Experimental results over a range of realistic database benchmarks indicate that our approach is highly effective in eliminating concurrency bugs, with safe refactored programs showing an average of 120% higher throughput and 45% lower latency compared to a serialized baseline.
Column randomization and almost-isometric embeddings

∣ ≤ δ √ k‖x‖ 2 . We show that if A is (δ, k)-regular for 1 ≤ k ≤ 1/δ, then by multiplying the columns of A by independent random signs, the resulting random ensemble Aε acts on an arbitrary subset T ⊂ R (almost) as if it were gaussian, and with the optimal probability estimate: if l∗(T ) is the gaussian mean-width of T and dT = supt∈T ‖t‖2, then with probability at least 1− 2 exp(−c(l∗(T )/dT )), sup t∈T ∣ ∣‖Aεt‖2 − ‖t‖2 ∣
Conservative and accurate solution transfer between high-order and low-order refined finite element spaces

In this paper we introduce general transfer operators between high-order and low-order reﬁned ﬁnite element spaces that can be used to couple high-order and low-order simulations. Under natural restrictions on the low-order reﬁned space we prove that both the high-to-low-order and low-to-high-order linear mappings are conservative, constant preserving and high-order accurate. While the proofs apply to aﬃne geometries, numerical experiments indicate that the results hold for more general curved and mixed meshes. These operators also have applications in the context of coarsening solution ﬁelds deﬁned on meshes with nonconforming reﬁnement. The transfer operators for H 1 ﬁnite element spaces require a globally coupled solve, for which robust and eﬃcient preconditioners are developed. We present several numerical results conﬁrming our analysis and demonstrate the utility of the new mappings in the context of adaptive mesh reﬁnement and conservative multi-discretization coupling.
Clinical significance of hypertension in patients with different types of cancer treated with antiangiogenic drugs

Hypertension is a common comorbidity in patients receiving antiangiogenic therapy. Prior studies have reported worsening or new-onset hypertension as an adverse event of antiangiogenetic therapy, which can be managed by dose reduction or discontinuation of the culprit medication. By contrast, other studies have found that the occurrence of hypertension is a potential biomarker associated with greater efficacy of antiangiogenic therapy and predicts improved survival. At present, there is no consensus on the effects of hypertension in patients treated with antiangiogenic drugs. The present study reviewed the relationship between antiangiogenic drugs and hypertension in different types of cancer. It was demonstrated that the use of antiangiogenic drugs was associated with an increased risk of hypertension in most types of solid cancers. There was no significant difference in the incidence of hypertension between monoclonal antibody and small-molecule tyrosine kinase inhibitor treatments. Hypertension was more likely to occur in patients younger than 75 years old, female, and those with no history of bevacizumab use. Discontinuation or death caused by hypertension was rare, although previous studies have reported that hypertension was a risk factor for acute and chronic cardiovascular diseases and ischemic stroke. Of note, the early development of hypertension may serve as a potential biomarker associated with greater efficacy of antiangiogenic therapy.
Comparison and interpretability of machine learning models to predict severity of chest injury

Abstract Objective Trauma quality improvement programs and registries improve care and outcomes for injured patients. Designated trauma centers calculate injury scores using dedicated trauma registrars; however, many injuries arrive at nontrauma centers, leaving a substantial amount of data uncaptured. We propose automated methods to identify severe chest injury using machine learning (ML) and natural language processing (NLP) methods from the electronic health record (EHR) for quality reporting. Materials and Methods A level I trauma center was queried for patients presenting after injury between 2014 and 2018. Prediction modeling was performed to classify severe chest injury using a reference dataset labeled by certified registrars. Clinical documents from trauma encounters were processed into concept unique identifiers for inputs to ML models: logistic regression with elastic net (EN) regularization, extreme gradient boosted (XGB) machines, and convolutional neural networks (CNN). The optimal model was identified by examining predictive and face validity metrics using global explanations. Results Of 8952 encounters, 542 (6.1%) had a severe chest injury. CNN and EN had the highest discrimination, with an area under the receiver operating characteristic curve of 0.93 and calibration slopes between 0.88 and 0.97. CNN had better performance across risk thresholds with fewer discordant cases. Examination of global explanations demonstrated the CNN model had better face validity, with top features including “contusion of lung” and “hemopneumothorax. ” Discussion The CNN model featured optimal discrimination, calibration, and clinically relevant features selected. Conclusion NLP and ML methods to populate trauma registries for quality analyses are feasible.
Epigallocatechin-3-Gallate Promotes the in vitro Maturation and Embryo Development Following IVF of Porcine Oocytes

Purpose Epigallocatechin-3-gallate (EGCG) is a major ingredient of catechin polyphenols and exerts protective effects because of its strong antioxidant properties. As far as we know, there is still a lack of systematic research on the effects of EGCG on the in vitro maturation (IVM) and in vitro fertilization (IVF) of porcine oocytes. The present study aimed to determine the effects of EGCG on the IVM and IVF of porcine oocytes. Methods Porcine oocytes were treated with different concentrations of EGCG (5, 10 and 20 µM), and the cumulus cell expansion, oocyte maturation rate, reactive oxygen species (ROS), glutathione (GSH) and malondialdehyde (MDA) levels, total antioxidant capacity were determined. The mRNA expression levels of oxidative stress- and apoptosis-associated genes were determined by quantitative real-time PCR. The cleavage rate and blastocyst rate of oocytes after 10 μM EGCG treatment during IVM and IVF were also evaluated. Results EGCG at 5, 10 and 20 μM significantly promoted cumulus cell expansion, and EGCG at 10 μM increased the oocyte maturation rate. EGCG (10 μM) treatment reduced the ROS and MDA levels, while increased the antioxidant capacity and GSH concentrations in the mature oocytes. The qRT-PCR results showed that EGCG treatment up-regulated the mRNA expression of catalase, glutathione peroxidase and superoxide dismutase in the mature oocytes. In addition, EGCG treatment also decreased the mRNA expression levels of Bax and caspase-3 and increased the Bcl-2 mRNA expression level in the mature oocytes. In addition, the cleavage rate and blastocyst rate of oocytes treated with 10 μM EGCG during IVM and IVF were significantly higher than those of the control group. Conclusion Our results suggest that EGCG promotes the in vitro maturation and embryo development following IVF of porcine oocytes. The protective effects of EGCG on the oocytes may be associated with its antioxidant and anti-apoptosis properties.
Geographic patterns of genomic diversity and structure in the C4 grass Panicum hallii across its natural distribution

Abstract Geographic patterns of within-species genomic diversity are shaped by evolutionary processes, life history and historical and contemporary factors. New genomic approaches can be used to infer the influence of such factors on the current distribution of infraspecific lineages. In this study, we evaluated the genomic and morphological diversity as well as the genetic structure of the C4 grass Panicum hallii across its complex natural distribution in North America. We sampled extensively across the natural range of P. hallii in Mexico and the USA to generate double-digestion restriction-associated DNA (ddRAD) sequence data for 423 individuals from 118 localities. We used these individuals to study the divergence between the two varieties of P. hallii, P. hallii var. filipes and P. hallii var. hallii as well as the genetic diversity and structure within these groups. We also examined the possibility of admixture in the geographically sympatric zone shared by both varieties, and assessed distribution shifts related with past climatic fluctuations. There is strong genetic and morphological divergence between the varieties and consistent genetic structure defining seven genetic clusters that follow major ecoregions across the range. South Texas constitutes a hotspot of genetic diversity with the co-occurrence of all genetic clusters and admixture between the two varieties. It is likely a recolonization and convergence point of populations that previously diverged in isolation during fragmentation events following glaciation periods.
Colorectal cancer burden and trends: Comparison between China and major burden countries in the world

Objective To summarize the colorectal cancer (CRC) burden and trend in the world, and compare the difference of CRC burden between other countries and China. Methods Incidence and mortality data were extracted from the GLOBOCAN2018 and Cancer Incidence in Five Continents. Age-specific incidence trend was conducted by Joinpoint analysis and average annual percent changes were calculated. Results About 1.85 million new cases and 0.88 million deaths were expected in 2018 worldwide, including 0.52 million (28.20%) new cases and 0.25 million (28.11%) deaths in China. Hungary had the highest age-standardized incidence and mortality rates in the world, while for China, the incidence and mortality rates were only half of that. CRC incidence and mortality were highly correlated with human development index (HDI). Unlike the rapid increase in Republic of Korea and the downward trend in Canada and Australia, the age-standardized incidence rates by world standard population in China and Norway were rising gradually. The age-specific incidence rate in the age group of 50−59 years in China was increasing rapidly, while in Republic of Korea and Canada, the fastest growing age group was 30−39 years. Conclusions The variations of CRC burden reflect the difference of risk factors, as well as levels of HDI and screening (early detection activities). The burden of CRC in China is high, and the incidence of CRC continues to increase, which may lead to a sustained increase in the burden of CRC in China in the future. Screening should be expanded to control CRC, and focused on young people in China.
Short loop functional commonality identified in leukaemia proteome highlights crucial protein sub-networks

Abstract Direct drug targeting of mutated proteins in cancer is not always possible and efficacy can be nullified by compensating protein–protein interactions (PPIs). Here, we establish an in silico pipeline to identify specific PPI sub-networks containing mutated proteins as potential targets, which we apply to mutation data of four different leukaemias. Our method is based on extracting cyclic interactions of a small number of proteins topologically and functionally linked in the Protein–Protein Interaction Network (PPIN), which we call short loop network motifs (SLM). We uncover a new property of PPINs named ‘short loop commonality’ to measure indirect PPIs occurring via common SLM interactions. This detects ‘modules’ of PPI networks enriched with annotated biological functions of proteins containing mutation hotspots, exemplified by FLT3 and other receptor tyrosine kinase proteins. We further identify functional dependency or mutual exclusivity of short loop commonality pairs in large-scale cellular CRISPR–Cas9 knockout screening data. Our pipeline provides a new strategy for identifying new therapeutic targets for drug discovery.
The prevalence of adult attention-deficit hyperactivity disorder: A global systematic review and meta-analysis

Background Adult attention-deficit hyperactivity disorder (ADHD) has recently attracted much attention, however, an up-to-date estimation on the prevalence of adult ADHD is lacking. In this study, we aimed to assess the global prevalence of adult ADHD in the general population through a systematic review and meta-analysis. Methods PubMed, Medline, Embase and PsycINFO were searched to identify relevant articles published from January 2000 onwards. Population-based studies that were conducted in the general adult population and quantified the prevalence of adult ADHD were included. Results The prevalence of persistent adult ADHD (with a childhood onset) and symptomatic adult ADHD (regardless of a childhood onset) both decreased with advancing age. By adjusting for the global demographic structure in 2020, the prevalence of persistent adult ADHD was 2.58% and that of symptomatic adult ADHD was 6.76%, translating to 139.84 million and 366.33 million affected adults in 2020 globally. Conclusions This study provides an up-to-date estimation of the global prevalence of both persistent and symptomatic adult ADHD. A well-defined strategy for diagnosing adult ADHD and large-scale investigations on the epidemiology of adult ADHD are needed.
STUDIES ON COMPLEXES OF COBALT(II), NICKEL(II), COPPER(II), AND CADMIUM(II) WITH ACETOPHENONE AND 4-HYDROXYACETOPHENONE SALICYLOYL AND ISONICOTINOYLHYDRAZONES

ABSTRACT Metal(II) complexes of the types [M(L)mCl2(H2O)n] and [Cu(L′)SO4(H2O)2] [M˭Co(II), Ni(II), Cu(II) and Cd(II), L˭acetophenone salicyloylhydrazone (ASH) OHC6H4CONHN˭C(CH3)C6H5, m=2, n=2; 4-hydroxyacetophenone salicyloylhydrazone (4-HOASH), m=2, n=0; acetophenone isonicotinoylhydrazone (AINH), NC5H4CONHN˭C(CH3)- C6H5, m=1, n=2; 4-hydroxyacetophenone isonicotinoylhydrazone (4-HOAINH), NC5H4CONHN˭C(CH3)C6H4OH, m=1, n=2, and L′=4-HOAINH and 4-HOASH] were prepared and characterized by elemental and thermal analyses, molar conductance, magnetic susceptibility, infrared, electronic, NMR, ESR and X-ray powder diffraction studies. Some of the complexes were screened against E. coli and Aspergillus niger to explore their biological activity.
Theoretical and Experimental Investigation of a Two-Bed Adsorption System Using a Novel Adsorber Configuration

To improve the performance of an adsorption system for cooling applications, a novel integrated adsober/evaporator configuration made of a bellows structure was described. A two-bed adsorption system arrangement using the bellows adsorber and zeolite 13X/water working-pair and related mathematical analysis was also presented. Results of computer modelling and experimental tests of various operating and performance parameters of the system including operating temperature and pressure in the adsorbent bed, mass transfer, COP and SCC were discussed.
Global prevalence of burnout among postgraduate medical trainees: a systematic review and meta-regression

Background: Burnout among postgraduate medical trainees (PMTs) is increasingly being recognized as a crisis in the medical profession. We aimed to establish the prevalence of burnout among PMTs, identify risk and protective factors, and assess whether burnout varied by country of training, year of study and specialty of practice. Methods: We systematically searched MEDLINE, Embase, PsycINFO, the Cochrane Database of Systematic Reviews, Web of Science and Education Resources Information Center from their inception to Aug. 21, 2018, for studies of burnout among PMTs. The primary objective was to identify the global prevalence of burnout among PMTs. Our secondary objective was to evaluate the association between burnout and country of training, year of study, specialty of training and other sociodemographic factors commonly thought to be related to burnout. We employed random-effects meta-analysis and meta-regression techniques to estimate a pooled prevalence and conduct secondary analyses. Results: In total, 8505 published studies were screened, 196 met eligibility and 114 were included in the meta-analysis. The pooled prevalence of burnout was 47.3% (95% confidence interval 43.1% to 51.5%), based on studies published over 20 years involving 31 210 PMTs from 47 countries. The prevalence of burnout remained unchanged over the past 2 decades. Burnout varied by region, with PMTs of European countries experiencing the lowest level. Burnout rates among medical and surgical PMTs were similar. Interpretation: Current wellness efforts and policies have not changed the prevalence of burnout worldwide. Future research should focus on understanding systemic factors and leveraging these findings to design interventions to combat burnout. Study registration: PROSPERO no. CRD42018108774
Full methylation of H3K27 by PRC2 is dispensable for initial embryoid body formation but required to maintain differentiated cell identity.

Polycomb repressive complex 2 (PRC2) catalyzes methylation of histone H3 on lysine 27 and is required for normal development of complex eukaryotes. The nature of that requirement is not clear. H3K27me3 is associated with repressed genes, however the modification is not sufficient to induce repression, and in some instances is not required. We blocked full methylation of H3K27 with both a small molecule inhibitor, GSK343 and by introducing a point mutation into EZH2, the catalytic subunit of PRC2. Cells with substantively decreased H3K27 methylation differentiate into embryoid bodies, which contrasts with EZH2 null cells. PRC2 targets had varied requirements for H3K27me3, with a subset that maintained normal levels of repression in the absence of methylation. The primary cellular phenotype of blocked H3K27 methylation was an inability of altered cells to maintain a differentiated state when challenged. This phenotype was determined by H3K27 methylation in embryonic stem cells through the first four days of differentiation. Full H3K27 methylation therefore was not necessary for formation of differentiated cell states during embryoid body formation but was required to maintain a stable differentiated state.
Look-ahead fixations during visuomotor behavior: Evidence from assembling a camping tent

Eye movements can support ongoing manipulative actions, but a class of so-called look ahead fixations (LAFs) are related to future tasks. We examined LAFs in a complex natural task—assembling a camping tent. Tent assembly is a relatively uncommon task and requires the completion of multiple subtasks in sequence over a 5- to 20-minute duration. Participants wore a head-mounted camera and eye tracker. Subtasks and LAFs were annotated. We document four novel aspects of LAFs. First, LAFs were not random and their frequency was biased to certain objects and subtasks. Second, latencies are larger than previously noted, with 35% of LAFs occurring within 10 seconds before motor manipulation and 75% within 100 seconds. Third, LAF behavior extends far into future subtasks, because only 47% of LAFs are made to objects relevant to the current subtask. Seventy-five percent of LAFs are to objects used within five upcoming steps. Last, LAFs are often directed repeatedly to the target before manipulation, suggesting memory volatility. LAFs with short fixation–action latencies have been hypothesized to benefit future visual search and/or motor manipulation. However, the diversity of LAFs suggest they may also reflect scene exploration and task relevance, as well as longer term problem solving and task planning.
Geometrically restricted image descriptors: A method to capture the appearance of shape

Shape perception varies depending on many factors. For example, presenting a stimulus in the periphery often yields a different appearance compared with its foveal presentation. However, how exactly shape appearance is altered under different conditions remains elusive. One reason for this is that studies typically measure identification performance, leaving details about target appearance unknown. The lack of appearance-based methods and general challenges to quantify appearance complicate the investigation of shape appearance. Here, we introduce Geometrically Restricted Image Descriptors (GRIDs), a method to investigate the appearance of shapes. Stimuli in the GRID paradigm are shapes consisting of distinct line elements placed on a grid by connecting grid nodes. Each line is treated as a discrete target. Observers are asked to capture target appearance by placing lines on a freely viewed response grid. We used GRIDs to investigate the appearance of letters and letter-like shapes. Targets were presented at 10° eccentricity in the right visual field. Gaze-contingent stimulus presentation was used to prevent eye movements to the target. The data were analyzed by quantifying the differences between targets and response in regard to overall accuracy, element discriminability, and several distinct error types. Our results show how shape appearance can be captured by GRIDs, and how a fine-grained analysis of stimulus parts provides quantifications of appearance typically not available in standard measures of performance. We propose that GRIDs are an effective tool to investigate the appearance of shapes.