Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of obesity in gestational hypertension in primigravidae women: A case control study in Shadegan, Iran

Background: Gestational hypertension is a serious problem among pregnant women in Shadegan. This study was conducted to estimate the prevalence and risk factors of gestational hypertension in these women. Methods: In this study, the prevalence of gestational hypertension was estimated. Then, a case-control study was performed on 310 pregnant women with gestational hypertension and 930 healthy pregnant women in 2014. Multiple logistic regression was used to explore the possible risk factors. The analysis was repeated in a subgroup of primigravidae women to identify the risk factors that led to gestational hypertension. Results: The prevalence of gestational hypertension among pregnant women in Shadegan was 9.6%. Moreover, multiple logistic regression of all pregnant women showed that obese pregnant women were 1.79 times (OR = 1.79; 95%CI= 1.19-2.71; p<0.005) more likely to have gestational hypertension. Overweight and obese primigravidae women were 2.13 (OR= 2.1; 95%CI= 1.031-4.34; p<0.041) and 4.8 (OR= 2.4; 95%CI= 1.13-5.16; p<0.022) times more likely to have gestational hypertension than women with normal BMI, respectively. Age, education, history of gestational hypertension, and type of residential area of the primigravidae women were also significant factors. Conclusion: BMI is the most important risk factor for gestational hypertension. More focus needs to be laid on this issue to raise awareness on the preservation of proper BMI before pregnancy, which can help decrease gestational hypertension.
Probiotic Potential of Noni and Mulberry Juice Fermented with Lactic Acid Bacteria

The present study assesses the feasibility of noni and mulberry as a raw substrate for the production of probiotic noni and mulberry juice by lactic acid bacteria (Lactobacillus plantarum SK-3 and Pediococcus acidilactici M-3). Changes in pH, titratable acidity (lactic acid), cell survival, and antioxidant properties were examined during fermentation. Both the strains grew well in noni juice and mulberry juice after 48 hour fermentation. P. acidilactici M-3 produced less lactic acid than L. plantarum SK-3. After 28 days of cold storage, both tested strains survived the low-pH conditions in fermented noni juice and mulberry juice. Both the juices fermented with L. plantarum SK-3 had a high antioxidant capacity. The noni and mulberry juice fermented with L. plantarum SK-3 had shown the cholesterol-lowering ability better than the juices fermented with P. acidilactici M-3. Finally, L. plantarum SK-3 and P. acidilactici M-3 were found as optimal probiotics for fermentation with noni juice as well as mulberry juice. In this investigation, the results could be an indicator of the development of health-promoting food juices.
Analysis of the CDK4/6 Cell Cycle Pathway in Leiomyosarcomas as a Potential Target for Inhibition by Palbociclib

Leiomyosarcoma (LMS) is characterized by high genomic complexity, and to date, no specific targeted therapy is available. In a genome-wide approach, we profiled genomic aberrations in a small cohort of eight primary tumours, two relapses, and eight metastases across nine different patients. We identified CDK4 amplification as a recurrent alteration in 5 out of 18 samples (27.8%). It has been previously shown that the LMS cell line SK-LMS-1 has a defect in the p16 pathway and that this cell line can be inhibited by the CDK4 and CDK6 inhibitor palbociclib. For SK-LMS-1 we confirm and for SK-UT-1 we show that both LMS cell lines express CDK4 and that, in addition, strong CDK6 expression is seen in SK-LMS-1, whereas Rb was expressed in SK-LMS-1 but not in SK-UT-1. We confirm that inhibition of SK-LMS-1 with palbociclib led to a strong decrease in protein levels of Phospho-Rb (Ser780), a decreased cell proliferation, and G0/G1-phase arrest with decreased S/G2 fractions. SK-UT-1 did not respond to palbociclib inhibition. To compare these in vitro findings with patient tissue samples, a p16, CDK4, CDK6, and p-Rb immunohistochemical staining assay of a large LMS cohort (n=99 patients with 159 samples) was performed assigning a potential responder phenotype to each patient, which we identified in 29 out of 99 (29.3%) patients. Taken together, these data show that CDK4/6 inhibitors may offer a new option for targeted therapy in a subset of LMS patients.
Myopia – A 21st Century Public Health Issue

Serge Resnikoff, Jost B. Jonas, David Friedman, Mingguage He, Monica Jong, Jason J. Nichols, Kyoko Ohno-Matsui, Earl L. Smith III, Christine F. Wildsoet, Hugh R. Taylor, James S. Wolffsohn, and Tien Y. Wong Brien Holden Vision Institute and School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karis-University Heidelberg, Mannheim, Germany Dana Center for Preventive Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States Centre for Eye Research Australia; Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Australia University of Alabama at Birmingham, School of Optometry, Birmingham, Alabama, United States Tokyo Medical and Dental University, Tokyo, Japan College of Optometry, University of Houston, Houston, Texas, United States Berkeley Myopia Research Group, School of Optometry & Vision Science Program, University of California Berkeley, Berkeley, California, United States Melbourne Laureate Professor and Chair of Indigenous Eye Health, University of Melbourne, Melbourne, Victoria, Australia Ophthalmic Research Group, Aston University, Birmingham, United Kingdom Singapore Eye Research Institute, Singapore National Eye Center, Duke-NUS Medical School, National University of Singapore, Singapore
Habitat differentiation among three Nigeria–Cameroon chimpanzee (Pan troglodytes ellioti) populations

Abstract Ecological niche models (ENMs) are often used to predict species distribution patterns from datasets that describe abiotic and biotic factors at coarse spatial scales. Ground‐truthing ENMs provide important information about how these factors relate to species‐specific requirements at a scale that is biologically relevant for the species. Chimpanzees are territorial and have a predominantly frugivorous diet. The spatial and temporal variation in fruit availability for different chimpanzee populations is thus crucial, but rarely depicted in ENMs. The genetic and geographic distinction within Nigeria–Cameroon chimpanzee (Pan troglodytes ellioti) populations represents a unique opportunity to understand fine scale species‐relevant ecological variation in relation to ENMs. In Cameroon, P. t. ellioti is composed of two genetically distinct populations that occupy different niches: rainforests in western Cameroon and forest–woodland–savanna mosaic (ecotone) in central Cameroon. We investigated habitat variation at three representative sites using chimpanzee‐relevant environmental variables, including fruit availability, to assess how these variables distinguish these niches from one another. Contrary to the assumption of most ENM studies that intact forest is essential for the survival of chimpanzees, we hypothesized that the ecotone and human‐modified habitats in Cameroon have sufficient resources to sustain large chimpanzee populations. Rainfall, and the diversity, density, and size of trees were higher at the rainforest. The ecotone had a higher density of terrestrial herbs and lianas. Fruit availability was higher at Ganga (ecotone) than at Bekob and Njuma. Seasonal variation in fruit availability was highest at Ganga, and periods of fruit scarcity were longer than at the rainforest sites. Introduced and secondary forest species linked with anthropogenic modification were common at Bekob, which reduced seasonality in fruit availability. Our findings highlight the value of incorporating fine scale species‐relevant ecological data to create more realistic models, which have implications for local conservation planning efforts.
Armet, an aphid effector protein, induces pathogen resistance in plants by promoting the accumulation of salicylic acid

Effector proteins present in aphid saliva are thought to modulate aphid–plant interactions. Armet, an effector protein, is found in the phloem sap of pea-aphid-infested plants and is indispensable for the survival of aphids on plants. However, its function in plants has not been investigated. Here, we explored the functions of Armet after delivery into plants. Examination of the transcriptomes of Nicotiana benthamiana and Medicago truncatula following transgenic expression of Armet or infiltration of the protein showed that Armet activated pathways associated with plant–pathogen interactions, mitogen-activated protein kinase and salicylic acid (SA). Armet induced a fourfold increase in SA accumulation by regulating the expression of SAMT and SABP2, two genes associated with SA metabolism, in Armet-infiltrated tobacco. The increase in SA enhanced the plants' resistance to bacterial pathogen Pseudomonas syringae but had no detectable adverse effects on aphid survival or reproduction. Similar molecular responses and a chlorosis phenotype were induced in tobacco by Armet from two aphid species but not by locust Armet, suggesting that the effector function of Armet may be specific for aphids. The results suggest that Armet causes plants to make a pathogen-resistance decision and reflect a novel tripartite insect–plant–pathogen interaction. This article is part of the theme issue ‘Biotic signalling sheds light on smart pest management’.
Factors associated with adverse childhood experiences in Scottish children: a prospective cohort study

Background and objectives Adverse childhood experiences (ACEs) have been associated with a range of poorer health and social outcomes throughout the life course; however, to date they have primarily been conducted retrospectively in adulthood. This paper sets out to determine the prevalence of ACEs at age 8 in a recent prospective birth cohort and examine associations between risk factors in the first year and cumulative ACEs. Design This study uses the Growing Up in Scotland Birth Cohort 1, in which children born in Scotland in 2004/5 were identified using Child Benefit Records and followed up for 7 years (n.3119). ACE scores and sample characteristics were calculated and described. Logistic regression models were fitted to explore associations between risk factors (sex, mother’s age and education, household income, area level deprivation and urban/rural indicator) and ACE scores. Results Seven ACEs (or proxies) were assessed: physical abuse, domestic violence, substance abuse, mental illness, parental separation, parental incarceration and emotional neglect. Instances of sexual abuse were too few to be reported. Emotional abuse and physical neglect could not be gathered. Around two-thirds of children had experienced one or more ACE, with 10% experiencing three or more in their lifetime. Higher ACE scores were associated with being male, having a young mother, low income and urban areas. Conclusions Using prospective data, the majority of children born in 2004/2005 in Scotland experienced at least one ACE by age 8, although three ACEs could not be assessed in this cohort. ACEs were highly correlated with socioeconomic disadvantage in the first year of life.
Leiomyosarcoma of the Right Gonadal Vein: Review of the Approach and Prognostic in a Rare Case

Background Venous leiomyosarcoma is a mesenchymal tumour that represents 5-7% of soft tissue sarcomas. It originates in the smooth muscle cells of the vessel wall and is frequently located in the inferior vena cava. Primary leiomyosarcomas of the gonadal vein are rare, with only 10 cases reported in the literature. Case report We present the case of a 51-year-old woman diagnosed with a right retroperitoneal mass by computed tomography (CT). The differential diagnosis was between a neurogenic tumour and a mesodermic tumour. The tumour was dissected from the vena cava and right ureter by laparoscopy without performing resection en bloc. Histologic examination of the surgical specimen showed a high-grade leiomyosarcoma of the right gonadal vein. The postoperative course was uneventful. Three cycles of chemotherapy with epirubicin-ifosfamide were performed. Discussion and conclusions Venous leiomyosarcoma is an aggressive tumour, and prognosis is poor due to haematogenous spread. No chemotherapy or radiotherapy has yet proven effective in improving survival, and complete surgical excision is currently considered to offer the best chance of cure. Despite the more conservative treatment approach used in the present case, the patient is alive three years after surgery and has a good quality of life. Although it was not used in this patient, the standard procedure for optimal survival is resection en bloc.
Extraction and purification of the H9N2 virus nucleoprotein: A simple and practical method

Background: Avian Influenza disease annually entails a significant economic loss to the poultry industry around the world. Influenza virus is a polymorphic virus of the orthomyxoviridae family (single-stranded RNA genome), and nucleoprotein (NP) is the structural and internal protein of the virus. The aim of the work was to purify nucleoprotein for further investigations with a simple, low-cost, fast and practical method. Methods: In this study, H9N2 influenza virus was isolated in specific pathogen-free embryonated chicken eggs by allantoically inoculating 103 to 105 egg-infective doses (EID50) for 9 to 11 days, purified by 10% (W/V) polyethylene glycol (PEG) 6000 with a sucrose gradient of 60% to 30%. The influenza virus proteins were collected and prepared as fractions by preparative electrophoresis. Finally, the purified NP was subjected to sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot procedures. Results: The protein analysis with SDS-PAGE and silver nitrate staining indicated that the desired samples contained purified nucleoprotein and lacked other viral proteins. The results of the investigation of lyophilized fractions containing nucleoprotein on the SDS-PAGE revealed the absence of viral RNA in nucleoprotein and its high purity. Conclusion: According to this study, purified nucleoprotein can be used to produce nucleoprotein vaccines, as well as to study structural, molecular and diagnostic and therapeutic materials.
BeautyNet: Joint Multiscale CNN and Transfer Learning Method for Unconstrained Facial Beauty Prediction

Because of the lack of discriminative face representations and scarcity of labeled training data, facial beauty prediction (FBP), which aims at assessing facial attractiveness automatically, has become a challenging pattern recognition problem. Inspired by recent promising work on fine-grained image classification using the multiscale architecture to extend the diversity of deep features, BeautyNet for unconstrained facial beauty prediction is proposed in this paper. Firstly, a multiscale network is adopted to improve the discriminative of face features. Secondly, to alleviate the computational burden of the multiscale architecture, MFM (max-feature-map) is utilized as an activation function which can not only lighten the network and speed network convergence but also benefit the performance. Finally, transfer learning strategy is introduced here to mitigate the overfitting phenomenon which is caused by the scarcity of labeled facial beauty samples and improves the proposed BeautyNet's performance. Extensive experiments performed on LSFBD demonstrate that the proposed scheme outperforms the state-of-the-art methods, which can achieve 67.48% classification accuracy.
Low Molecular Weight Heparin-Coated and Dendrimer-Based Core-Shell Nanoplatform with Enhanced Immune Activation and Multiple Anti-Metastatic Effects for Melanoma Treatment

High-efficiency treatment for tumor is not easy to achieve owing to the existence of metastasis, which remains the arch-criminal of most tumor deaths. Conventional chemotherapy exhibits insufficient inhibitory efficiency on tumor metastasis and more powerful strategies to conquer metastatic tumors are urgently needed. In this study, a rational chemoimmunotherapy strategy was adopted to treat highly aggressive melanoma based on a newly developed multifunctional nanoplatform. Firstly, immunoadjuvant cytosine-phosphate-guanine oligonucleotides (CpG ODNs) were used to boost the doxorubicin (DOX)-elicited immune responses, which synergistically suppressed tumor growth and metastasis. And the anti-metastatic low molecular weight heparin (LMWH) was also integrated, thus multiple anti-metastatic effects to against tumor metastasis were achieved. Methods: G4 PAMAM was serving as the main support to conjugate DOX by pH-sensitive hydrazone bond (PPD) and the synthesized conjugates were confirmed by 1H-NMR spectra, IR spectra and HRMS. Immunoadjuvant CpG ODNs were loaded by electrostatic adsorption to formulate PPD/CpG. After the coating of anti-metastatic LMWH, the designed LMWH/PPD/CpG was fabricated and characterized. The platelets-related and platelets-unrelated anti-metastatic mechanisms were investigated on B16F10 melanoma cells. The capacity of DOX to elicit immunogenic cell death (ICD) on B16F10 melanoma cells was examined by flow cytometry, laser scanning confocal microscope and immumohistochemical staining. Then the immune activation effects, anti-tumor and anti-metastatic efficacy of LMWH/PPD/CpG were evaluated on a B16F10 melanoma xenograft model. Results: DOX elicited tumor-specific immune responses by ICD, and the immunological effects could be further promoted by CpG ODNs, exhibiting enhanced maturation of dendritic cells (DCs) and increased level of cytolytic T lymphocytes (CTLs) in vivo. Owing to the coating of LMWH, the platelets-induced epithelial-mesenchymal-like transition of tumor cells was hindered and the actin cytoskeletal arrangement of tumor cells was affected, thus the migration ability of tumor cells was further inhibited. This multifunctional nanoplatform showed enhanced treatment efficiency on melanoma primary tumor and pulmonary metastasis. Conclusion: The immune activation and multiple anti-metastatic effects of LMWH/PPD/CpG establish a novel therapeutic strategy for melanoma. This anti-metastatic nanoplatform could be broadly applied for the co-delivery of other nucleic acids and chemotherapeutic drugs to treat highly aggressive tumors.
Metal leaching from a spent catalyst by Alternaria alternata

El estudio evaluo la habilidad de lixiviacion d el medio extracelular producido por un hongo, el cual fue identificado como Alternaria alternata . El estudio comprendio la seleccion de un medio de cultivo que favor ece la produccion de acidos organicos y de sideroforos , los medios de cultivo evaluados fueron m edio de sacarosa y Czapek. Una vez seleccionado el medio de cultivo, se continuo con el estudio de biolixiviacion de metales de un catalizador al 1 y 5%, utilizando el medio extracelular en medio de sacarosa e incubando a 30°C, 150 rpm durante 7 dias. Los resultados indicaron que el medio extracelular disminuyo su pH de 6 a 4.8 ; en este medio se producen sideroforos . E l estudio de lixiviacion de metales en presencia del catalizador demostro que el extracto del hongo es capaz de lixiviar metales ; la concentracion del catalizador tiene un efecto importante sobre la remocion de los metales y sobre la especificidad hacia los met ales; a una concentracion de catalizador del 1%, se removieron los siguientes metales, en orden descendente, V > Al > Si > Mo > Mg > Fe > Ni > As > Cr despues de 48 h. Este es el primer reporte sobre la remocion de metales a partir de un catalizad or por el medio extracelular de A . alternata lo cual abre nueva s alternativas de investigacion para el tratamiento de residuos peligrosos con alto contenido metalico
Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors

Pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide. However, its toll is higher in more developed countries. Reasons for vast differences in mortality rates of pancreatic cancer are not completely clear yet, but it may be due to lack of appropriate diagnosis, treatment and cataloging of cancer cases. Because patients seldom exhibit symptoms until an advanced stage of the disease, pancreatic cancer remains one of the most lethal malignant neoplasms that caused 432,242 new deaths in 2018 (GLOBOCAN 2018 estimates). Globally, 458,918 new cases of pancreatic cancer have been reported in 2018, and 355,317 new cases are estimated to occur until 2040. Despite advancements in the detection and management of pancreatic cancer, the 5-year survival rate still stands at 9% only. To date, the causes of pancreatic carcinoma are still insufficiently known, although certain risk factors have been identified, such as tobacco smoking, diabetes mellitus, obesity, dietary factors, alcohol abuse, age, ethnicity, family history and genetic factors, Helicobacter pylori infection, non-O blood group and chronic pancreatitis. In general population, screening of large groups is not considered useful to detect the disease at its early stage, although newer techniques and the screening of tightly targeted groups (especially of those with family history), are being evaluated. Primary prevention is considered of utmost importance. Up-to-date statistics on pancreatic cancer occurrence and outcome along with a better understanding of the etiology and identifying the causative risk factors are essential for the primary prevention of this disease.
Effects of Temperature and Moisture on Soil Organic Carbon Mineralization

As an important index of soil fertility and ecological balance, soil organic carbon had been universal concern. This paper summarized research conditions of temperature and moisture on soil organic carbon in recent years, introduces the effects of temperature, freezing-thawing cycles, water and dry-wet cycles on soil organic carbon mineralization, and discusses the dynamics research of soil organic carbon mineralization, proposed to be further resolved problems.
Aprendizado de Métrica Supervisionado para Classificador por Arestas de Suporte

Resumo Como outros modelos baseados em informações de margem, os Classificadores por Arestas de Suporte (CLAS) utilizam propriedades intŕınsecas dos Grafos de Gabriel para filtrar amostras na região de separação visando a suavizar a resposta do classificador. A abordagem utilizada está sujeita à distribuição das amostras na região de superposição e pode depender do conjunto de dados. Como alternativa, propõe-se, neste trabalho, uma etapa de aprendizado de métrica supervisionado baseado no método Large Margin Nearest Neighbors no treinamento de modelos CLAS com o efeito de reduzir a sobreposição entre as classes e controlar também a suavização do modelo.