Miracle-dz/UniFAR-FTUs huggingface dataset:
Rapeseed Hulls Fat Characteristics

Rapeseed hull which tends to be eliminated from the seeds before technological processing, contains considerable amounts of fat (14–19%). Neither the composition not the properties of the fat hve been known well so far hence the investigation to determine the possibilities of its utilization have been undertaken. The analysis of fat extracted with petroleum ether from thoroughly purified hulls of several varieties of rapeseed cultivated in Poland proved that it contained less triglycerides (ab. 10%), more polar fat (ab. 5%) and 2% of partial glycerides compared with the fat from cotyledones. Hull fat was also characterized by a considerably higher acid value as well as by a lower stability compared with cotyledones fat and whole rapeseeds fat. The established low quality of hull fat shows the possibilities of its non-consumptive utilization and indicates that dehulling brings upon the improvement both of rapeseed meal as a feed and of raw fat. Eigenschaften des Fetts von Rapsschalen Rapsschalen, die meistens vor der technischen Verarbeitung aus der Saat entfernt werden, enthalten beachtliche Fettmengen (14–19%). Weder die Zusammensetzung noch die Fetteigenschaften waren genugend bekannt, so das deswegen die Untersuchung uber die Anwendungsmoglichkeiten vorgenommen wurde. Die Analyse des Fetts, das mit Petrolather aus grundlich gereinigten Schalen mehrerer Rapssorten, die in Polen angebaut wurden, extrahiert wurde, zeigte, das es weniger Triglyceride (ca. 10%), mehrpolare Fette (ca. 5%) und 2% Mono-und Diglyceride enthielt im Vergleich zu dem Fett der Keimblatter. Das Schalenfett zeichnete sich auch durch einen betrachtlich hoheren Saurewert ebenso wie durch eine geringere Stabilitat im Vergleich zu dem Keimblattfett und dem Gesamtrapsfett aus. Die festgestellte geringe Qualitat des Schalenfetts zeigt die Moglichkeiten seiner Verwendung auserhalb der Ernahrung und macht deutlich, das das Entschalen eine Verbesserung des Rapsmehls sowohl als Futter als auch als Rohfett bewirkt.
Privacy Assessment in Mobile Health Apps: Scoping Review

Background Privacy has always been a concern, especially in the health domain. The proliferation of mobile health (mHealth) apps has led to a large amount of sensitive data being generated. Some authors have performed privacy assessments of mHealth apps. They have evaluated diverse privacy components; however, different authors have used different criteria for their assessments. Objective This scoping review aims to understand how privacy is assessed for mHealth apps, focusing on the components, scales, criteria, and scoring methods used. A simple taxonomy to categorize the privacy assessments of mHealth apps based on component evaluation is also proposed. Methods We followed the methodology defined by Arksey and O’Malley to conduct a scoping review. Included studies were categorized based on the privacy component, which was assessed using the proposed taxonomy. Results The database searches retrieved a total of 710 citations—24 of them met the defined selection criteria, and data were extracted from them. Even though the inclusion criteria considered articles published since 2009, all the studies that were ultimately included were published from 2014 onward. Although 12 papers out of 24 (50%) analyzed only privacy, 8 (33%) analyzed both privacy and security. Moreover, 4 papers (17%) analyzed full apps, with privacy being just part of the assessment. The evaluation criteria used by authors were heterogeneous and were based on their experience, the literature, and/or existing legal frameworks. Regarding the set of items used for the assessments, each article defined a different one. Items included app permissions, analysis of the destination, analysis of the content of communications, study of the privacy policy, use of remote storage, and existence of a password to access the app, among many others. Most of the included studies provided a scoring method that enables the comparison of privacy among apps. Conclusions The privacy assessment of mHealth apps is a complex task, as the criteria used by different authors for their evaluations are very heterogeneous. Although some studies about privacy assessment have been conducted, a very large set of items to evaluate privacy has been used up until now. In-app information and privacy policies are primarily utilized by the scientific community to extract privacy information from mHealth apps. The creation of a scale based on more objective criteria is a desirable step forward for privacy assessment in the future.
Influenza vaccine efficacy induced by orally administered recombinant baculoviruses

Although vaccine delivery through the oral route remains the most convenient and safest way for mass immunization purposes, this method is limited by the requirement for large antigen doses and low vaccine efficacy. In this study, we generated recombinant baculoviruses (rBVs) expressing influenza hemagglutinin (A/PR/8/34) and orally delivered a low dose of rBVs to evaluate its vaccine efficacy in mice. Intranasal rBV vaccination was included in the whole experiment for comparison. We found that oral vaccination elicited high levels of virus-specific IgG and IgA antibody responses in both serum and mucosal samples (lung, tracheal, intestinal, fecal and vaginal). Surprisingly, complete protection from the lethal influenza challenge was observed, as indicated by reductions in the virus titer, inflammatory cytokine production, body weight change, and enhanced survival. These results suggest that oral delivery of the influenza rBV vaccine induces mucosal and systemic immunity, which protect mice from the lethal influenza virus challenge. Oral delivery of baculovirus vaccines can be developed as an effective vaccination route.
Distribution and status of the Pallas’s Fish Eagle Haliaeetus leucoryphus in Mongolia: a cause for conservation concern?

Summary Pallas’s Fish Eagle Haliaeetus leucoryphus (PFE) is sparsely distributed across a vast swathe of central, eastern and southern Asia, and is classified as ‘Vulnerable’ by IUCN on the basis of population size and reports of declines in many areas. Mongolia has long been considered a breeding stronghold for the species, but evidence to support this is unclear. Our objective was to assess the current distribution and status of the PFE in Mongolia to enable a more accurate assessment of the species’ conservation status, through collation of existing information from the historical literature, and a contemporary survey of historical sites and potential PFE breeding habitat. Thirty-four traceable locations were identified in the historical literature, of which breeding activity had been recorded in seven. Field surveys were conducted at a total of 77 sites throughout the study period (2005–2011) between April and October, including 21 of the historical PFE locations. PFE were observed at eight sites, all of which were historical PFEs locations, and no evidence of breeding activity was recorded. These findings suggest that Mongolia is not (and may never have been) a breeding stronghold for the PFE. The lack of eagles at 13 of 21 historical sites surveyed, coupled with a lack of sightings of birds at alternative locations is suggestive of a decline in site occupancy. Observations of juvenile eagles within one month of the spring thaw suggests that at least a proportion of Mongolian PFEs are breeding at southern latitudes, and future studies to establish these migratory linkages are warranted. These findings, coupled with evidence of declines in other parts of the PFE range indicate a need to re-evaluate the species’ conservation status, and in particular to determine the number of mature PFEs present in suitable habitat in the Indian Subcontinent and Myanmar between November and March.
CCL17 in Inflammation and Pain

Key Points GM-CSF–dependent CCL17 is expressed predominantly in macrophage lineage populations. CCL17 acts on CCR4+ non–bone marrow–derived cells for arthritic pain development. GM-CSF→CCL17 pathway–dependent pain requires NGF, CGRP, and substance P. It has been reported that a GM-CSF→CCL17 pathway, originally identified in vitro in macrophage lineage populations, is implicated in the control of inflammatory pain, as well as arthritic pain and disease. We explore, in this study and in various inflammation models, the cellular CCL17 expression and its GM-CSF dependence as well as the function of CCL17 in inflammation and pain. This study used models allowing the convenient cell isolation from Ccl17E/+ reporter mice; it also exploited both CCL17-dependent and unique CCL17-driven inflammatory pain and arthritis models, the latter permitting a radiation chimera approach to help identify the CCL17 responding cell type(s) and the mediators downstream of CCL17 in the control of inflammation and pain. We present evidence that 1) in the particular inflammation models studied, CCL17 expression is predominantly in macrophage lineage populations and is GM-CSF dependent, 2) for its action in arthritic pain and disease development, CCL17 acts on CCR4+ non–bone marrow–derived cells, and 3) for inflammatory pain development in which a GM-CSF→CCL17 pathway appears critical, nerve growth factor, CGRP, and substance P all appear to be required.
PERSISTENCE OF CARBARYL (SEVIN-4-OIL®) IN WOODLAND PONDS AND ITS EFFECTS ON POND MACROINVERTEBRATES FOLLOWING FOREST SPRAYING

Abstract The impact of an experimental aerial application of carbaryl (Sevin-4-oil®) on the macroinvertebrate fauna of woodland ponds was studied in northern Maine. Carbaryl was applied at the rate of 840 g A.I./ha, the same rate as was used for control of spruce budworm, Choristoneura fumiferana (Clemens), damage. Four treated ponds and three untreated ponds were observed for up to 30 months following treatment. Maximum residue levels of 254 μg/L were found in the water and 53,793 μg/kg (dry weight) in the sediment. Residues were detectable in the water 14 months and in the sediment 16 months after treatment. The most severe and persistent impact was on the Amphipoda with Hyallela azteca (Saussure) and Crangonyx richmondensis Ellis reduced to near 0/m2 and failing to recolonize in some of the ponds 30 months after treatment. Numbers of immature Ephemeroptera and Trichoptera were reduced immediately following spray application but this impact did not persist throughout the season nor into the following year. Immediate reduction in numbers of adult Ephemeroptera and Trichoptera emerging from the ponds was also found. Numbers of immature Odonata were reduced following treatment and remained low during the following year. The Chironomidae did not appear affected either as immatures or emerging adults. Résumé L'impact des applications aériennes de carbaryl (Sevin-4-oil®) sur la macro-faune invertébrée d'étangs du sous-bois a été étudié dans le nord du Maine. Le carbaryl a été appliqué à la dose de 840 g I.A. /ha, soit la dose appliquée pour le contrôle des dommages causés par la tordeuse, Choristoneura fumiferana (Clemens). Des observations ont été faites dans quatre étangs traités et 3 étangs non-traités, jusqu'à 30 mois après le traitement. Des niveaux maximum de résidus de 254 μg/L ont été observés dans l'eau, et de 53,793 μg/kg (poids sec) dans les sédiments. Des niveaux détectables de résidus ont été trouvés 14 mois après le traitement dans l'eau, et 16 mois après le traitement dans les résidus. L'impact le plus important et le plus persistant a été noté pour les Amphipoda, Hyallela azteca (Saussure) et Crangonyx richmondensis Ellis ayant été réduits à près de 0/m2, et la recolonisation n'ayant pas eu lieu dans certains étangs 30 mois après le traitement. Les nombres d'Ephemeroptera et de Trichoptera immatures ont été réduits immédiatement après l'arrosage, mais cet effet n'a pas persisté au cours de la saison, ni l'année suivante. Une réduction immédiate des nombres d'Ephemeroptera et de Trichoptera adultes ayant émergé des étangs a aussi été observée. Les nombres d'Odonata immatures ont été réduits après le traitement et sont demeurés bas l'année suivante. Les Chironomidae n'ont pas semblé affectés à l'état d'immatures, ni comme adultes émergés.
Biological control of Sclerotinia minor using a chitinolytic bacterium and actinomycetes

Isolates of 85 bacteria and 94 streptomycete and 35 nonstreptomycete actinomycetes were obtained from a lettuce-growing field in Al-Ain, United Arab Emirates, on colloidal chitin agar, and screened for their ability to produce chitinase. Twenty-three bacteria and 38 streptomycete and 15 nonstreptomycete actinomycete isolates produced high levels of chitinase and were examined in vitro for their ability to suppress the growth of Sclerotinia minor, a pathogen causing basal drop disease of lettuce. The three most suppressive isolates were examined further for their production of β-1,3-glucanase and antifungal activity as well as their ability to colonize the roots and rhizosphere of lettuce in vitro and in planta. The three isolates, Serratia marcescens, Streptomyces viridodiasticus and Micromonospora carbonacea, significantly reduced the growth of S. minor in vitro, and produced high levels of chitinase and β-1,3-glucanase. Streptomyces viridodiasticus also produced antifungal metabolite(s) that significantly reduced the growth of the pathogen in vitro. When the pathogen was presented as the sole carbon source, all three isolates caused extensive hyphal plasmolysis and cell wall lysis. Serratia marcescens and St. viridodiasticus were competent to varying degrees in colonizing the roots of lettuce seedlings after 8 days on agar plates and the rhizosphere within 14 days in pots, with their competency being superior to that of M. carbonacea. All three isolates, individually or in combination, were antagonistic to S. minor and significantly reduced incidence of disease under controlled glasshouse conditions.
“Forever young”—Postnatal growth inhibition of the turbinal skeleton in brachycephalic dog breeds (Canis lupus familiaris)

In short snouted (brachycephalic) dogs (Canis lupus familiaris), several genetic mutations cause postnatal growth inhibition of the viscerocranium. Thus, for example, the pug keeps a snub nose like that observed in neonate dogs in general. However, little is known how far intranasal structures like the turbinal skeleton are also affected. In the present study, we provide the first detailed morphological and morphometric analyses on the turbinal skeleton of pug, Japanese chin, pekingese, King Charles spaniel, and Cavalier. In order to elucidate how a shortened snout affects turbinal shape, size, and density, our sample covers different degrees of brachycephaly. Macerated skulls of 1 juvenile and 17 adult individuals were investigated by μCT and virtual 3D reconstructions. In addition, histological serial sections of two prenatal and one neonate whippet were taken into account. All investigated postnatal stages show three frontoturbinals and three ethmoturbinals similar to longer snouted breeds, whereas the number of interturbinals is reduced. The shape of the entire turbinal skeleton simplifies with decreasing snout length, that is, within a minimized nasal cavity the turbinals decrease proportionally in surface area and surface density due to a looser arrangement. We interpret these apparent reductions as a result of spatial constraint which affects postnatal appositional bone growth and the position of the turbinals inside the nasal cavity. The turbinal skeleton of brachycephalic dogs arrests at an early ontogenetic stage, corresponding with previous studies on the dermal bones. Hence, we assume an association between the growth of intranasal structures and facial elongation.
MicroRNA‐708 modulates Hepatic Stellate Cells activation and enhances extracellular matrix accumulation via direct targeting TMEM88

Transmembrane protein 88 (TMEM88) is a potential 2‐transmembrane‐type protein that interacts with the PDZ domain of Dishevelled‐1 (DVL‐1), a crucial component of Wnt signalling pathway through its C‐terminal Val‐Trp‐Val (VWV) motif in Xenopus embryo cells. Since the significant function of β‐catenin in liver fibrosis, it is urgent to study the TMEM88 mechanism in liver fibrosis. The current research was for evaluating the function of TMEM88 in the process of the liver fibrosis and clarifying the inherent mechanism. The study found that TMEM88 is decreased in human fibrotic liver tissues. Functionally, TMEM88 significantly reduced the expression levels of α‐smooth muscle actin (α‐SMA) and collagen type I (Col.I) and repressed extracellular matrix (ECM) accumulation by restoring the balance between matrix metalloproteinases (MMPs) and TIMPs (tissue inhibitor of metalloproteinases). TMEM88 inhibited HSCs proliferation and evaluated the apoptosis of activated LX‐2 cells by regulating Wnt3a, Wnt2b and β‐catenin of Wnt/β‐catenin signalling pathway. Moreover, we demonstrated that miR‐708 particularly targeted TMEM88 3′‐UTR regions and down‐regulated the expression level of TMEM88 in TGF‐β1‐stimulated LX‐2 cells. MiR‐708 promoted the generation of ECM and cell activation in activated LX‐2 cells. These results determined that miR‐708 could promote HSCs activation and enhance ECM accumulation via direct targeting TMEM88 by Wnt/β‐catenin signalling pathway. This will provide a potential target for future research in the process of liver fibrosis.
Food sources, behaviour, and distribution of hydrothermal vent shrimps at the Mid-Atlantic Ridge

Five species of bresilioid shrimp were investigated at seven hydrothermal sites on the Mid-Atlantic Ridge: Menez Gwen, Lucky Strike, Rainbow, Broken Spur, TAG, Snake Pit and Logatchev. Samples were prepared for analysis of stable isotopes, elemental composition and lipids. Shrimp behaviour was observed from the submersible ‘Alvin’ and in the laboratory aboard RV ‘Atlantis’. The distribution and zonation of the shrimp species was recorded. Juvenile shrimp of all species arrive at the vents carrying reserves of photosynthetic origin, built-up in the pelagic larval stages. These reserves are used while the shrimp metamorphose to the adult form and, in Rimicaris exoculata and Chorocaris chacei, while they develop epibiotic bacteria supporting structures, the modified mouthparts and the inside of the carapace. The main food of adult R. exoculata is filamentous bacteria that grow on these structures. The intermediate sizes of C. chacei also feed on such bacteria, but the final stage gets some food by scavenging or predation. Mirocaris species scavenge diverse sources; they are not trophically dependent on either R. exoculata or mussels. Adults of Alvinocaris markensis are predators of other vent animals, including R. exoculata. The dense swarms of R. exoculata, with their exosymbionts, can be compared to endosymbiont-containing animals such as Bathymodiolus and the vestimentiferan tube-worms of the Pacific vents. Such associations, whether endo- or ectosymbiotic, may be necessary for the development of flourishing communities at hydrothermal vents.
Initiation of roots on hypocotyl cuttings of Pinus contorta in vitro

The origin of roots and wound tissue after treatments for induction of roots on hypocotyl cuttings of three-week-old Pinus contorta Dougl. ex Loud, is discussed. The cuttings were cultured in vitro and treated with 1.2 μM to 1.5 M IBA (indole-3-butyric acid) for 6 h to 10 days. The control, which was not treated with IBA developed a wound tissue from which roots formed. Cuttings treated with IBA developed roots directly from the hypocotyl. Direct rooting was faster than indirect rooting via a wound tissue. Rooting was considered to be optimal if more than 80% of the cuttings rooted within 19 days and half of the cuttings which possessed roots after one month had acquired them within 14 days. This type of rooting was obtained after treatment with either 80 μM IBA for 4 to 6 days or 1.25 to 5.0 mM IBA for 6 h. Suboptimal treatments gave lower rooting percentages and superoptimal treatments resulted in delayed rooting. In IBA-treated cuttings, large increases in mitotic activity (number of mitoses per mm hypocotyl) were found in the pericycle and parenchyma inside endodermis. However, the control also had similar mitotic activities as the IBA-treated cuttings but closer to the cut surface. This led us to the conclusion that similar tissues may produce either wound tissue or roots. Almost all roots obtained through direct rooting originated outside resin ducts.
Evidence of Subpopulations of Lake Whitefish, Coregonus clupeaformis, Involving a Dwarfed Form

Abstract An unusually small, mature whitefish which appeared to be identical to the lake whitefish, Coregonus clupeaformis, was found in 22 lakes in northwestern Maine in 1957-62. In most lakes the “dwarfed” form was found sympatric with “normal” lake whitefish, but populations that are completely dwarfed were found in three lakes. Distinct differences have been found in the size and age at which the two forms of whitefish become sexually mature, in their rate of growth, in their morphology, and in their erythrocyte antigens. Information on spawning habits provides further evidence of two separate breeding populations. All evidence leads to the conclusion that the two forms of lake whitefish are discrete, and that at least a partial barrier to gene flow exists between them. The differences between the two forms are highly variable from lake to lake, making any conclusions as to their systematic relationship tenuous. It is suggested that this variation may be due in part to varying degrees of convergence o.
National Trends in Antibiotic Use in Australian Residential Aged Care Facilities, 2005-2016.

BACKGROUND Understanding current patterns of antibiotic use in residential aged care facilities (RACFs) is essential to inform stewardship activities, but limited utilization data exist. This study examined changes in prevalence and consumption of antibiotics in Australian RACFs between 2005-2006 and 2015-2016. METHODS This population-based, repeated cross-sectional analysis included all long-term permanent residents of Australian RACFs between July 2005 and June 2016 who were aged ≥ 65 years. The yearly prevalence rate of antibiotic use and number of defined daily doses (DDDs) of systemic antibiotics per 1000 resident-days were determined annually from linked pharmaceutical claims data. Trends were assessed using ordinary least squares regression. RESULTS This study included 502 752 residents from 3218 RACFs, with 424.9 million resident-days analyzed. Antibiotics were dispensed on 5 608 126 occasions during the study period, of which 88% were for oral use. Cefalexin, amoxicillin-clavulanic acid, and trimethoprim were the most commonly dispensed antibiotics. The annual prevalence of antibiotic use increased from 63.8% (95% confidence interval [CI], 63.3%-64.4%) to 70.3% (95% CI, 69.9%-70.7%) between 2005-2006 and 2015-2016 (0.8% average annual increase, P < .001). There was a 39% relative increase in total consumption of systemic antibiotics, with utilization increasing from 67.6 to 93.8 DDDs/1000 resident-days during the study period (average annual increase of 2.8 DDDs/1000 resident-days, P < .001). CONCLUSIONS This nationwide study showed substantial increases in both prevalence of use and total consumption of antibiotics in Australian RACFs between 2005 and 2016. The increasingly widespread use of antibiotics in Australian RACFs is concerning and points to a need for enhanced efforts to optimize antibiotic use in this setting.