Miracle-dz/UniFAR-FTUs huggingface dataset:
Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection

Crimean-Congo hemorrhagic fever virus is an important human pathogen with a wide global distribution for which no therapeutic interventions are available. CCHFV encodes a cysteine protease belonging to the ovarian tumor (OTU) family which is involved in host immune suppression. Here we demonstrate that artificially prolonged binding of the OTU to a substrate inhibits virus infection. This provides novel insights into CCHFV OTU function during the viral replicative cycle and highlights the OTU as a potential antiviral target. ABSTRACT Crimean-Congo hemorrhagic fever virus (CCHFV) infection can result in a severe hemorrhagic syndrome for which there are no antiviral interventions available to date. Certain RNA viruses, such as CCHFV, encode cysteine proteases of the ovarian tumor (OTU) family that antagonize interferon (IFN) production by deconjugating ubiquitin (Ub). The OTU of CCHFV, a negative-strand RNA virus, is dispensable for replication of the viral genome, despite being part of the large viral RNA polymerase. Here, we show that mutations that prevent binding of the OTU to cellular ubiquitin are required for the generation of recombinant CCHFV containing a mutated catalytic cysteine. Similarly, the high-affinity binding of a synthetic ubiquitin variant (UbV-CC4) to CCHFV OTU strongly inhibits viral growth. UbV-CC4 inhibits CCHFV infection even in the absence of intact IFN signaling, suggesting that its antiviral activity is not due to blocking the OTU’s immunosuppressive function. Instead, the prolonged occupancy of the OTU with UbV-CC4 directly targets viral replication by interfering with CCHFV RNA synthesis. Together, our data provide mechanistic details supporting the development of antivirals targeting viral OTUs. IMPORTANCE Crimean-Congo hemorrhagic fever virus is an important human pathogen with a wide global distribution for which no therapeutic interventions are available. CCHFV encodes a cysteine protease belonging to the ovarian tumor (OTU) family which is involved in host immune suppression. Here we demonstrate that artificially prolonged binding of the OTU to a substrate inhibits virus infection. This provides novel insights into CCHFV OTU function during the viral replicative cycle and highlights the OTU as a potential antiviral target.
Weight Gain After Simultaneous Kidney and Pancreas Transplantation

Background. Excessive weight (EW) gain is common after solid organ transplantation, but there is little information concerning obesity after pancreas transplantation. The study goal was to characterize EW gain after kidney-pancreas (KP) transplantation. Methods. This was a retrospective single-center review of 100 KP recipients transplanted between September 2007 and June 2015. Results. The median percent weight gain for all recipients at 1 year posttransplant was 10% (interquartile range, 2.7%–19.3%) of baseline weight. EW gain, defined as greater than or equal to a 19% 1-year increase in weight, included all recipients (n = 26) above the upper limit of interquartile range for weight gain at 1 year. In multivariate analysis, recipient age <40 years, the use of tacrolimus/mammalian target of rapamycin immunosuppression, and an acute rejection event were independent risk factors for EW gain. At a mean follow-up of 43±23 months, there was no difference in patient or graft survival between the EW and non-EW cohorts. Although mean hemoglobin A1c levels between groups were equivalent, the EW versus non-EW cohort displayed a significant increase in mean insulin levels and a trend towards higher C-peptide levels. Criteria for posttransplant metabolic syndrome was met in 34.6% of EW versus 17.6% of non-EW cohorts (P = 0.07). Conclusions. At intermediate-term follow-up, EW gain after KP transplantation was not associated with an increased risk of death or graft loss, although there was a trend toward a greater risk of posttransplant metabolic syndrome. There may be a metabolic consequence of successful pancreas transplantation that results in EW gain in a proportion of recipients, leading to an increased risk of long-term cardiovascular complications.
Consumer Acceptability, Eye Fixation, and Physiological Responses: A Study of Novel and Familiar Chocolate Packaging Designs Using Eye-Tracking Devices

Eye fixations on packaging elements are not necessarily correlated to consumer attention or positive emotions towards those elements. This study aimed to assess links between the emotional responses of consumers and the eye fixations on areas of interest (AOI) of different chocolate packaging designs using eye trackers. Sixty participants were exposed to six novel and six familiar (commercial) chocolate packaging concepts on tablet PC screens. Analysis of variance (ANOVA) and multivariate analysis were performed on eye tracking, facial expressions, and self-reported responses. The results showed that there were significant positive correlations between liking and familiarity in commercially available concepts (r = 0.88), whereas, with novel concepts, there were no significant correlations. Overall, the total number of fixations on the familiar packaging was positively correlated (r = 0.78) with positive emotions elicited in people using the FaceReader™ (Happy), while they were not correlated with any emotion for the novel packaging. Fixations on a specific AOI were not linked to positive emotions, since, in some cases, they were related to negative emotions elicited in people or not even associated with any emotion. These findings can be used by package designers to better understand the link between the emotional responses of consumers and their eye fixation patterns for specific AOI.
Gid10 as an alternative N-recognin of the Pro/N-degron pathway

Significance In eukaryotes, N-degron pathways comprise proteolytic systems whose unifying feature is their ability to recognize proteins containing N-terminal degradation signals called N-degrons, thereby causing degradation of these proteins. Gid4, a subunit of the GID ubiquitin ligase in the yeast Saccharomyces cerevisiae, is the recognition component (N-recognin) of the Pro/N-degron pathway. Gid4 targets proteins by recognizing their N-terminal Pro residues or a Pro at position 2. We identified an uncharacterized Gid4-like yeast protein, termed Gid10. A screen for N-terminal sequence motifs that can bind to Gid10 showed that substrate specificities of Gid10 and Gid4 overlap but are not identical. We also found that Gid10 can function as a specific N-recognin of the GID ubiquitin ligase and the Pro/N-degron pathway. In eukaryotes, N-degron pathways (formerly “N-end rule pathways”) comprise a set of proteolytic systems whose unifying feature is their ability to recognize proteins containing N-terminal degradation signals called N-degrons, thereby causing degradation of these proteins by the 26S proteasome or autophagy. Gid4, a subunit of the GID ubiquitin ligase in the yeast Saccharomyces cerevisiae, is the recognition component (N-recognin) of the GID-mediated Pro/N-degron pathway. Gid4 targets proteins by recognizing their N-terminal Pro residues or a Pro at position 2, in the presence of distinct adjoining sequence motifs. Under conditions of low or absent glucose, cells make it through gluconeogenesis. When S. cerevisiae grows on a nonfermentable carbon source, its gluconeogenic enzymes Fbp1, Icl1, Mdh2, and Pck1 are expressed and long-lived. Transition to a medium containing glucose inhibits the synthesis of these enzymes and induces their degradation by the Gid4-dependent Pro/N-degron pathway. While studying yeast Gid4, we identified a similar but uncharacterized yeast protein (YGR066C), which we named Gid10. A screen for N-terminal peptide sequences that can bind to Gid10 showed that substrate specificities of Gid10 and Gid4 overlap but are not identical. Gid10 is not expressed under usual (unstressful) growth conditions, but is induced upon starvation or osmotic stresses. Using protein binding analyses and degradation assays with substrates of GID, we show that Gid10 can function as a specific N-recognin of the Pro/N-degron pathway.
Diabetic Retinopathy, lncRNAs, and Inflammation: A Dynamic, Interconnected Network

Diabetic retinopathy (DR) is reaching epidemic levels globally due to the increase in prevalence of diabetes mellitus (DM). DR also has detrimental effects to quality of life, as it is the leading cause of blindness in the working-age population and the most common cause of vision loss in individuals with DM. Over several decades, many studies have recognized the role of inflammation in the development and progression of DR; however, in recent years, accumulating evidence has also suggested that non-coding RNAs, especially long non-coding (lncRNAs), are aberrantly expressed in diabetes and may play a putative role in the development and progression of DR through the modulation of gene expression at the transcriptional, post-transcriptional, or epigenetic level. In this review, we will first highlight some of the key inflammatory mediators and transcription factors involved in DR, and we will then introduce the critical roles of lncRNAs in DR and inflammation. Following this, we will discuss the implications of lncRNAs in other epigenetic mechanisms that may also contribute to the progression of inflammation in DR.
Effect of Different Classes of Antihypertensive Drugs on Endothelial Function and Inflammation

Hypertension is characterized by structural and functional changes in blood vessels that travel with increased arterial stiffness, vascular inflammation, and endothelial dysfunction. Some antihypertensive drugs have been shown to improve endothelial function and reduce levels of inflammatory markers regardless of the effect of blood pressure lowering. Third-generation β-blockers, such as nebivolol and carvedilol, because they have additional properties, have been shown to improve endothelial function in patients with hypertension. Calcium channel antagonists, because they have antioxidant effects, may improve endothelial function and vascular inflammation.The Angiotensin Receptor Blocker (ARBs) are able to improve endothelial dysfunction and vascular inflammation in patients with hypertension and other cardiovascular diseases. Angiotensin converting enzyme (ACE) inhibitors have shown beneficial effects on endothelial function in patients with hypertension and other cardiovascular diseases, however there are few studies evaluating the effect of treatment with this class on the reduction of C-reactive protein (CRP) levels. Further studies are needed to assess whether treatment of endothelial dysfunction and vascular inflammation may improve the prognosis of patients with essential hypertension.
Responsiveness of the anterior cruciate ligament – Return to Sports after Injury (ACL-RSI) and Injury – Psychological Readiness to Return to Sport (I-PRRS) scales

ABSTRACT The ACL-Return to Sport after Injury (ACL-RSI) and Injury-Psychological Readiness to Return to Sport (I-PRRS) scales were developed to assess psychological factors associated with return to sports. Validity and reliability have been determined. The aim of this study was to investigate the responsiveness of the Dutch ACL-RSI and I-PRRS. Seventy patients with ACL reconstruction completed both scales twice 2 months apart, plus a Global Rating of Change (GRC) questionnaire. Distribution and logistic regression-based methods were used to study responsiveness. The Standardized Response Mean (SRM) for the ACL-RSI was 0.3 and for the I-PRRS 0.1, indicating low responsiveness. The minimally important change (MIC) for ACL-RSI was 2.6 and for the I-PRRS 0.9. Since the standard error of measurement (SEM) and smallest detectable change (SDC) were larger than MIC in individual patients, it does not seem possible to distinguish minimally important changes from measurement error in individual patients with either scale. At the group level responsiveness seemed sufficient; hence, both scales can be used to investigate the effectiveness of an intervention at the group level. Both scales can also be used in cross-sectional research and in clinical practice as screening instruments to identify patients at risk of not returning to sports.
What predictors are associated with the social inclusion of people with disabilities? A comparison of community-based rehabilitation participants to the general population in Vietnam

Abstract Purpose To estimate which predictors from the World Health Organization’s Community-Based Rehabilitation (CBR) Indicators have the strongest association with the social inclusion of people with disabilities who participate in CBR compared to the general population. Methods Data were collected using the CBR Indicators survey in Vietnam, including both CBR participants and the general population. A social inclusion score was created using seven questions covering the domains of interpersonal relationships and community participation. Additional questions were used as predictors and were grouped into five theoretical categories: sociodemographic, health, education, livelihood, and empowerment. Multivariate linear regression was used to show which predictors had a significant association with social inclusion. Results Seven predictors (one health, three livelihood, and three empowerment) explained 70.9% of the variance in social inclusion for CBR participants and seven predictors (two health, one education, three livelihood, and one empowerment) explained 58.8% of the variance for the general population. Age, gender, education, employment, and self-rated health had non-significant associations in both populations. Conclusions Livelihood and empowerment predictors showed the strongest association with social inclusion of CBR participants, and livelihood predictors for the general population. CBR programs should emphasize livelihood and empowerment activities to increase social inclusion of people with disabilities. Implications for rehabilitation Social inclusion is a human right which has emerged as a major priority in the United Nation’s Sustainable Development Goals. People with disabilities continue to experience low levels of social inclusion. It is important to determine which factors have the greatest impact on the social inclusion of people with disabilities. Although Community-Based Rehabilitation programs are often health focused, this study found that empowerment and livelihood predictors had the greatest association with social inclusion. Programs aiming to improve the social inclusion of people with disabilities should target empowerment and livelihood issues.
A Rapid URL-Based Spam Filtering System

The cat and mouse game between spammer and anti-spam vendors has continually evolved. As the latest gen- eration of spam incorporates sophisticated tactics, previous spam filtering technologies face a new challenge. In the term of spammers using URL-based anti-filtering techniques, we design a rapid URL-based spam filtering system. The system identifies spams through URL queries and uses Hplf hash function to accelerate query speed. It is proved that the system is an effective method of anti-spain by experiment.
Rfid Design Principles

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The Will To Change Poems 1968 1970

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NRC User Codes for EGSnrc

This manual describes the NRC User codes DOSRZnrc, CAVRZnrc, FLURZnrc and SPRRZnrc which all work with the EGSnrc Code system for Monte Carlo transport of electrons and photons (see NRC REPORT PIRS–701, “The EGSnrc Code System”). There is a graphical user interface available for creating the inputs to these codes (described separately).
Obstacles and Potential of IPv6 Unicast QoS Route Implementation

Based on IPv6 and its main OSPFv3 route protocol, this paper analyses the obstacles met possibly by IPv6 unicast QoS route, such as the current IPv4 QoS routing schemes are not appliable, the multiple QoS metrics are difficult to be expressed and their updates cost much to be flooded and so on. It develops the potential for IPv6 of how to use its simplified packet header, flow concept, traffic class and flow label fields to support QoS route.
Video coding method based on human visual system

This paper presented a video coding method based on human visual system.Based on the feature of the human visual system,detecting the fovea point and non-fovea block,through the use of the model of human visual system computed the weight of fovea block and non-fovea block.According to weight of them to decide the size of motion compensated block and bit allocation.Software simulation results show that the method can improve compression rate greatly and the image quality loss negligibly.
Reading aloud and the structure of information

ABSTRAC’i ‘ihe present article explores the role of English intonation in the organization of the information structure in read aluud poetry; and the extent tu which the reader reflects his or her interpretation of the text in the act of reading. In order tu account for this fact, two readings of the same poem are compared, the second of these after a discussion about the meaning of the poem. The analyses show how intonation patterns differ in both readings. 1. IN’iRODUCTION Reading aloud is a somewhat unusual activity which is mainly restricted tu religious, artistic, scholarly and political domains. Ihe act of reading in itself implies having tu provide an interpretation of the written text; and reading aloud mirrors the reader’s understanding of the text and, therefore, of the world that it depicts. The present article explores the degree of change in the informatiun structure uf a poem which is read aloud twice. ‘ihe main purpuse is tu discover the relationship between reading and the conceptual framework that the reader has in mmd when transferring the written text into the spoken mude.
Knowledge Transfer and Dynamics Behavior Pattern of Network Organization(I)

Previous studies suggested the interaction between knowledge transfer and structural characteristics and behavior pattern of network organization.In these research works,however,the process of knowledge transfer is explored from the micro-level.Little,concerning the macro-level dynamics behavior pattern of network organization and the links of micro-macro in the process of knowledge transfer,is considered.In this paper,virtual experiment(VE) is utilized to explore the interdependence of knowledge transfer and dynamics behavior pattern of network organization on the basis of rules system.
Genetic Algorithm Based on Adaptive Big Mutation Rate and Simulated Annealing and Its Application

To overcome premature or local-best solution , an adaptive big mutation rate algorithm based on simulated annealing, which copies big proportion of the fittest and also melts the theory of simulated annealing algorithm to assure its astringency, is put forward . The simulation to traveling salesman problem proves that the algorithm can rapidly get the best or second best solution.
A Novel Analog Decision-Feedback Equalizer in CMOS for Serial 10-Gb/sec Data Transmission Systems

To My Family iv ACKNOWLEDGEMENTS A long journey of formal education has come to a close and this is a good time to acknowledge the contributions that others have made toward my education. First, I would like to thank my advisor, Professor Joy Laskar for his encouragement, guidance and support during my five years in graduate school. His insight, suggestions for improvement, and his own achievements have been a constant source of motivation and encouragement for me. I will always be grateful to him for giving me the opportunity to pursue my graduate studies in his group.
Schedulability Analysis for Fault-tolerant Real-time System Under Rollback Recovery Model

A real-time system is required to guarantee its stringent requirements in real-time response and reliability since any task failing to response correctly within its deadline may result in a catastrophe.Based on the rollback recovery model,the paper presents a schedulability analysis for fault-tolerant real-time systems taking account of the effects of errors.The schedulability analytical method based on worst-case response time is applied in which fault-tolerant priority configuration is crucial to the system's schedulability.The main contribution of the approach is to deduce the computing formula of task's worst-case response time under a new priority configuring strategy which allows the lower priority task using the higher priority task's spare time to meet its deadline by lowering the faulty task's priority levels.The simulation shows that decreasing task's fault-tolerant priority can improve system fault resilience efficiently.
Natural Language Parsing: New Perspectives from Contemporary Biolinguistics

Automatic natural language processing captures a lion’s share of the attention in open information management. In one way or another, many applications have to deal with natural language input. In this chapter the authors investigate the problem of natural language parsing from the perspective of biolinguistics. They argue that the human mind succeeds in the parsing task without the help of languagespecific rules of parsing and language-specific rules of grammar. Instead, there is a universal parser incorporating a universal grammar. The main argument comes from language acquisition: Children cannot learn language specific parsing rules by rule induction due to the complexity of unconstrained inductive learning. They suggest that the universal parser presents a manageable solution to the problem of automatic natural language processing when compared with parsers tinkered for specific purposes. A model for a completely language independent parser is presented, taking a recent minimalist theory as a starting point.