Miracle-dz/UniFAR-FTUs huggingface dataset:
Memory conjunction errors for autobiographical events: More than just familiarity

Two diary studies investigated the prevalence of memory conjunction errors for real‐life events. In both studies, participants completed detailed diary pages over the course of several weeks. Participants in both diary studies committed memory conjunction errors on a later recognition memory test. In the second diary study participants also made remember/know judgements. For a large proportion of their memory conjunction errors participants indicated that they “remembered” the event occurring in that context. These diary studies demonstrate that memory conjunction errors do occur for autobiographical memories, and these errors can seem compelling.
Bromocriptine: old drug, new formulation and new indication

Bromocriptine is an ergot alkaloid dopamine D2 receptor agonist that has been used extensively in the past to treat hyperprolactinaemia, galactorrhoea and Parkinsonism. It is known that hypothalamic hypodopaminergic states and disturbed circadian rhythm are associated with the development of insulin resistance, obesity and diabetes in animals and humans. When administered in the early morning at the start of the light phase, a new quick release (QR) formulation of bromocriptine appears to act centrally to reset circadian rhythms of hypothalamic dopamine and serotonin and improve insulin resistance and other metabolic abnormalities. Phase II and III clinical studies show that QR‐bromocriptine lowers glycated haemoglobin by 0.6–1.2% (7–13 mmol/mol) either as monotherapy or in combination with other antidiabetes medications. Apart from nausea, the drug is well tolerated. The doses used to treat diabetes (up to 4.8 mg daily) are much lower than those used to treat Parkinson's disease and have not been associated with retroperitoneal fibrosis or heart valve abnormalities. QR‐bromocriptine (Cycloset™) has recently been approved in the USA for the treatment of type 2 diabetes mellitus (T2DM). Thus, a QR formulation of bromocriptine timed for peak delivery in the early morning may provide a novel neurally mediated approach to the control of hyperglycaemia in T2DM.
Working memory, executive function and impulsivity in Internet-addictive disorders: a comparison with pathological gambling

Objective The purpose of the present study was to test whether individuals with Internet addiction disorder (IAD) presented analogous characteristics of working memory, executive function and impulsivity compared with pathological gambling (PG) patients. Methods The subjects included 23 individuals with IAD, 23 PG patients and 23 controls. All of the participants were measured with the digit span task, Wisconsin Card Sorting Test, go/no-go task and Barratt Impulsiveness Scale-11 (BIS-11) under the same experimental conditions. Results The results of this study showed that the false alarm rate, total response errors, perseverative errors, failure to maintain set and BIS-11 scores of both the IAD and PG groups were significantly higher than that of the control group. In addition, the forward scores and backwards scores, percentage of conceptual level responses, number of categories completed and hit rate of the IAD and PG groups were significantly lower than that of the control group. Furthermore, the false alarm rate and BIS-11 scores of the IAD group were significantly higher than those of PG patients, and the hit rate was significantly lower than that of the PG patients. Conclusions Individuals with IAD and PG patients present deficiencies in working memory, executive dysfunction and impulsivity, and individuals with IAD are more impulsive than PG patients.
Secondary oesophageal or gastric cancer in patients treated for head and neck squamous cell carcinoma.

INTRODUCTION Patients with head and neck squamous cell carcinoma (HNSCC) are at an elevated risk of developing second primary malignancies (SPM). Our objectives were to estimate the excess risk of oesophageal and gastric SPMs in patients with malignancies of the pharynx or larynx and, additionally, to examine possible risk factors of developing SPMs. METHODS Data on all patients treated for HNSCC with curative intent in the Region of Southern Denmark in the period between 1 January 2000 and 31 December 2010 were reviewed. A total of 1,172 patients were identified. The combined data from the DAHANCA database, the Danish National Pathology Registry and the patient charts were analysed. RESULTS A total of 27 patients developed an SPM in the oesophagus or stomach corresponding to a standardised incidence ratio of 9.5 (95% confidence interval (CI): 6.5-13.9). Supraglottic (odds ratio (OR) = 6.9; p < 0.004) and hypopharyngeal (OR = 3.9; p < 0.049) index tumour sites were significant risk factors for developing SPM. The median survival of patients with SPM was 3.6 years (95% CI: 1.6-5.1; range: 0.7-12.4) from diagnosis of the index cancer compared with 3.4 years (95% CI: 3.1-4.3; range: 0.04-13.7) for patients without SPM. CONCLUSION In this study, we confirm that there is an elevated risk of developing oesophageal and gastric cancer in the Danish population of patients with a cancer in the supraglottic or hypopharyngeal region. Therefore, we recommend close follow-up of these patients and a low threshold for examination of the oesophagus and stomach. FUNDING not relevant. TRIAL REGISTRATION not relevant.
Income Level and Environmental Quality in The MENA Countries: Discussing the Environmental Kuznets Curve Hypothesis

This study extends the recent works of Liu (2005), Ang (2007), Apergis et al. (2009) and Payne (2010) by implementing recent bootstrap panel unit root tests and co-integration techniques to investigate the relationship between carbon dioxide emissions, energy consumption, and real GDP for 12 MENA countries over the period 1981–2005. Our results show that in the long-run energy consumption has a positive significant impact on CO2 emissions. More interestingly, we show that real GDP exhibits a quadratic relationship with CO2 emissions for the region as a whole. However, although the estimated long-run coefficients of income and its square satisfy the EKC hypothesis in most studied countries (except Tunisia, Morocco and UAE), the EKC turning points are very low in some cases and very high in the other cases, hence providing poor evidence in support of the EKC hypothesis (except for Jordan). Thus, our findings suggest that not all MENA countries need to sacrifice economic growth to decrease their emission levels as they may achieve CO2 emissions reduction via energy conservation without negative long run effects on economic growth.
Competitive Positioning and Generic Strategies : Revisiting the ’ Stuck in the Middle ’ proposition

We explorethe evolution of competitive positions using a formal model of competition with differentiated products in which production technologies improve over time. We show how the interplay between improving technologies and consumers’valuation of the resulting performance improvements affects whether or not the classic generic strategies of Low Cost and Differentiation remain viable in the face of a rival taking an intermediate position between them. We thus clarify when intermediate positions leave a firm’stuck in the middle’and when they allow a firm to ’dominate from the middle. ’Our focus on consumer choice and value creation complements the traditional focus in the strategy literature on competition and value capture.
Computer Support for Collaborative Learning

Contents: Introduction: Foundations for a CSCL Community. Part I: Keynote Discussions. Section 1: (Theory Track): Featured Foundational Papers. Part II: Long Papers. Section 2: (Theory Track): The Role of Artifacts in Collaborative Learning. Section 3: (Theory Track): Foundational Issues of CSCL. Section 4: (Methodology Track): Quantitative Analysis of Social Structures. Section 5: (Methodology Track): Qualitative Studies and Their Implications for CSCL. Section 6: (Pedagogy Track): Computer Support for Problem-Based Learning. Section 7: (Pedagogy Track): Computer Support to Scaffold Collaborative Learning. Section 8: (Pedagogy Track): Teachers and CSCL. Section 9: (Pedagogy Track): CSCL in the Broader Social Context. Section 10: (Technology Track): Synchronous Collaboration Support for Children. Section 11: (Technology Track): Synchronous Collaboration Support for Adults. Section 12: (Technology Track): Issues in the Design of Asynchronous Collaboration Systems. Section 13: (Technology Track): Issues of Representation in CSCL. Part III: Short Papers. Section 1: Issues in the Design of CSCL Systems. Section 2: Quantitative Analyses of Case Studies and Their Implications for CSCL. Section 3: Qualitative Analyses of Case Studies and Their Implications for CSCL. Part IV: Interactive Events. Section 1: Collaborative Workspaces. Section 2: Community and Culture. Section 3: New Media. Section 4: Online Communities. Section 5: PDAs and Ubiquitous Computing. Section 6: Professional Development. Section 7: Representational Scaffolding. Part V: Workshop Program. Part VI: Tutorial Program. Part VII: Doctoral Consortium Program.
Traffic grooming algorithms for reducing electronic multiplexing costs in WDM ring networks

We develop traffic grooming algorithms for unidirectional SONET/WDM ring networks. The objective is to assign calls to wavelengths in a way that minimizes the total cost of electronic equipment [e.g., the number of SONET add/drop multiplexers (ADM's)]. We show that the general traffic grooming problem is NP-complete. However, for some special cases we obtain algorithms that result in a significant reduction in the number of ADM's. When the traffic from all nodes is destined to a single node, and all traffic rates are the same, we obtain a solution that minimizes the number of ADM's. In the more general case of all-to-all uniform frame we obtain a lower bound on the number of ADM's required, and provide a heuristic algorithm that performs closely to that bound. To account for more realistic traffic scenarios, we also consider distance dependent traffic, where the traffic load between two nodes is inversely proportional to the distance between them, and again provide a nearly optimal heuristic algorithm that results in substantial ADM savings. Finally, we consider the use of a hub node, where traffic can be switched between different wavelength, and obtain an optimal algorithm which minimizes the number of ADM's by efficiently multiplexing and switching the traffic at the hub. Moreover, we show that any solution not using a hub can be transformed into a solution with a hub using fewer or the same number of ADM's.
Regional differences in the Okun’s Relationship: New Evidence for Spain (1980-2015)

This paper provides new empirical evidence on the relationship between the unemployment rate and the output growth in Spain at the regional level. The “gap version” with the output growth on the left-hand side of the equation is our benchmark model. We observe in our estimates that all coefficients are significant and show the expected negative sign. Significant regional differences in the Okun’s relationship, both for the short run and the long run, are found. These results are robust to two different specifications for the gaps: the HP filter and the QT procedure. In the final part of the paper, we also find that the OLS and the GMM estimates for panel data exhibit a similar pattern and that there is a clear asymmetry in the Okun’s relationship in booming and recession phases of the Spanish business cycle.
UvA-DARE ( Digital Academic Repository ) Crystallizing hard-sphere glasses by doping with active particles

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Engaging Values in Sustainable Agriculture and Food Systems Education: Toward an Explicitly Values-Based Pedagogical Approach

Agriculture education programs that provide integrative learning experiences that reflect the complexities, values, and challenges inherent to sustainable agriculture and food systems (SAFS) continue to evolve as faculty, staff, and students implement, experience, and modify them. Higher education institutions, especially land-grant universities, have strengths that position them to implement transformative learning and action methodologies. In this article we explore the principles, approaches, and practices consistent with integrative learning and a values-based pedagogical approach to curriculum design and teaching specific to SAFS. By a values-based pedagogical approach, we mean paying explicit attention to the values that (1) underpin different agricultural and food systems and their governance, (2) inform and shape educational strategies and experiences, and (3) are held by different individuals in various encounters in the learning environment. A values-based approach to SAFS curriculum development, teaching, and integrative learning is dynamic rather than static. We provide illustrations of practices across the education "life-cycle" — curriculum design, implementation, and evaluation — that have used values-based pedagogy to guide the development, modification, and strengthening of SAFS curricula. Finally, we discuss some limitations and issues that arise when using such pedagogical frameworks. We conclude by challenging educators to focus on connecting values relevant to SAFS with innovative curricular practices that allow emergence of new ways of teaching, learning, and knowing for all.
Transcriptional profiling identifies strain-specific effects of caloric restriction and opposite responses in human and mouse white adipose tissue

Caloric restriction (CR) has been extensively studied in rodents as an intervention to improve lifespan and healthspan. However, effects of CR can be strain- and species-specific. This study used publically available microarray data to analyze expression responses to CR in males from 7 mouse strains (C57BL/6J, BALB/c, C3H, 129, CBA, DBA, B6C3F1) and 4 tissues (epididymal white adipose tissue (eWAT), muscle, heart, cortex). In each tissue, the largest number of strain-specific CR responses was identified with respect to the C57BL/6 strain. In heart and cortex, CR responses in C57BL/6 mice were negatively correlated with responses in other strains. Strain-specific CR responses involved genes associated with olfactory receptors (Olfr1184, Olfr910) and insulin/IGF-1 signaling (Igf1, Irs2). In each strain, CR responses in eWAT were negatively correlated with those in human subcutaneous WAT (scWAT). In human scWAT, CR increased expression of genes associated with stem cell maintenance and vascularization. However, orthologous genes linked to these processes were down-regulated in mouse. These results identify strain-specific CR responses limiting generalization across mouse strains. Differential CR responses in mouse versus human WAT may be due to differences in the depots examined and/or the presence of “thrifty genes” in humans that resist adipose breakdown despite caloric deficit.
Defective signaling, osteoblastogenesis and bone remodeling in a mouse model of connexin 43 C-terminal truncation

ABSTRACT In skeletal tissue, loss or mutation of the gap junction protein connexin 43 (Cx43, also known as GJA1) in cells of the osteoblast lineage leads to a profound cortical bone phenotype and defective tissue remodeling. There is mounting evidence in bone cells that the C-terminus (CT) of Cx43 is a docking platform for signaling effectors and is required for efficient downstream signaling. Here, we examined this function, using a mouse model of Cx43 CT-truncation (Gja1 K258Stop). Relative to Gja1+/− controls, male Gja1−/K258Stop mice have a cortical bone phenotype that is remarkably similar to those reported for deletion of the entire Cx43 gene in osteoblasts. Furthermore, we show that the Cx43 CT binds several signaling proteins that are required for optimal osteoblast function, including PKCδ, ERK1 and ERK2 (ERK1/2, also known as MAPK3 and MAPK1, respectively) and β-catenin. Deletion of the Cx43 CT domain affects these signaling cascades, impacting osteoblast proliferation, differentiation, and collagen processing and organization. These data imply that, at least in bone, Cx43 gap junctions not only exchange signals, but also recruit the appropriate effector molecules to the Cx43 CT in order to efficiently activate signaling cascades that affect cell function and bone acquisition. Highlighted Article: The C-terminal domain of Cx43 in skeletal tissue affects signaling cascades and osteoblast function. Truncation of this domain recapitulates key aspects of Cx43 conditional deletion in bone.
Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study

Diffusion tensor imaging (DTI) can non-invasively examine the molecular diffusion of water in vivo and directly reflects the anatomical integrity of neural fibers in white matter. Fractional anisotropy (FA) can be calculated from DTI data, and utilized to evaluate white matter integrity. DTI was performed on 30 patients with schizophrenia and 19 healthy controls, and their FA values were subsequently measured in multiple brain regions. Statistical analyses revealed that FA values were decreased in the anterior cingulum of schizophrenia subjects. There were no significant differences between patients and controls in any other regions. This study supports the hypothesis that schizophrenia is associated with abnormal white matter integrity of the anterior cingulum.
THE VARIABLE GENOMIC ARCHITECTURE OF ISOLATION BETWEEN HYBRIDIZING SPECIES OF HOUSE MICE

Studies of the genetics of hybrid zones can provide insight into the genomic architecture of species boundaries. By examining patterns of introgression of multiple loci across a hybrid zone, it may be possible to identify regions of the genome that have experienced selection. Here, we present a comparison of introgression in two replicate transects through the house mouse hybrid zone through central Europe, using data from 41 single nucleotide markers. Using both genomic and geographic clines, we found many differences in patterns of introgression between the two transects, as well as some similarities. We found that many loci may have experienced the effects of selection at linked sites, including selection against hybrid genotypes, as well as positive selection in the form of genotypes introgressed into a foreign genetic background. We also found many positive associations of conspecific alleles among unlinked markers, which could be caused by epistatic interactions. Different patterns of introgression in the two transects highlight the challenge of using hybrid zones to identify genes underlying isolation and raise the possibility that the genetic basis of isolation between these species may be dependent on the local population genetic make‐up or the local ecological setting.
Specificity of the Type II Secretion Systems of Enterotoxigenic Escherichia coli and Vibrio cholerae for Heat-Labile Enterotoxin and Cholera Toxin

ABSTRACT The Gram-negative type II secretion (T2S) system is a multiprotein complex mediating the release of virulence factors from a number of pathogens. While an understanding of the function of T2S components is emerging, little is known about what identifies substrates for export. To investigate T2S substrate recognition, we compared mutations affecting the secretion of two highly homologous substrates: heat-labile enterotoxin (LT) from enterotoxigenic Escherichia coli (ETEC) and cholera toxin (CT) from Vibrio cholerae. Each toxin consists of one enzymatic A subunit and a ring of five B subunits mediating the toxin's secretion. Here, we report two mutations in LT's B subunit (LTB) that reduce its secretion from ETEC without global effects on the toxin. The Q3K mutation reduced levels of secreted LT by half, and as with CT (T. D. Connell, D. J. Metzger, M. Wang, M. G. Jobling, and R. K. Holmes, Infect. Immun. 63:4091-4098, 1995), the E11K mutation impaired LT secretion. Results in vitro and in vivo show that these mutants are not degraded more readily than wild-type LT. The Q3K mutation did not significantly affect CT B subunit (CTB) secretion from V. cholerae, and the E11A mutation altered LT and CTB secretion to various extents, indicating that these toxins are identified as secretion substrates in different ways. The levels of mutant LTB expressed in V. cholerae were low or undetectable, but each CTB mutant expressed and secreted at wild-type levels in ETEC. Therefore, ETEC's T2S system seems to accommodate mutations in CTB that impair the secretion of LTB. Our results highlight the exquisitely fine-tuned relationship between T2S substrates and their coordinate secretion machineries in different bacterial species.
Fluorescent Antibody‐Viability Staining and β‐Glucuronidase Assay as Rapid Methods for Monitoring Escherichia coli Viability in Coastal Marine Waters

Abstract A faecal pollution monitoring of coastal Messina waters was performed by comparing three (microscopic, enzyme, and culture) methods. Evidence of Escherichia coli cells (29.99 to 96.79% of the total enteropathogenic serotypes) retaining their viability into the marine environment was shown. β‐Glucuronidase activity rates suggested that living cells were also metabolically active. Heavily polluted sites were detected, where improperly treated urban wastes were discharged. Significant relationships between microscopic and enzymatic data proved both methods to be suitable alternatives to the culture method for E. coli detection, improving environmental quality assessment.
Arterial blood supply of hepatocellular carcinoma and histologic grading: radiologic-pathologic correlation.

OBJECTIVE The objective of our study was to clarify the sequential changes of arterial blood supply during the development of hepatocellular carcinoma (HCC) with an emphasis on its late stage. MATERIALS AND METHODS Sixty HCC nodules were confirmed at pathology in 59 patients who had undergone CT hepatic arteriography and CT during arterioportography (CTAP). Lesions were classified into one of the four groups: group 1, nodules that appeared to show preserved portal perfusion on CTAP and showed hypo- or isoattenuation on CT hepatic arteriography; group 2, very hyperattenuating on CT hepatic arteriography; group 3, hyperattenuating on CT hepatic arteriography; and group 4, hypo- or isoattenuating on CT hepatic arteriography. Groups 2, 3, and 4 showed the portal perfusion defect on CTAP. These hemodynamic patterns were compared among different histologic grades. We also examined the number of unpaired arteries and the Ki-67 labeling index of the tumor pathologically. RESULTS The numbers of lesions in each group were as follows for groups 1, 2, 3, and 4, respectively: 17, one, two, and 0 well-differentiated HCCs; 0, 10, nine, and one moderately differentiated HCC; and 0, three, 12, and five poorly differentiated HCCs. The lesions showed significantly different hemodynamic patterns among different histologic grades (Cramer's V = 0.6919, p < 0.0001). The number of unpaired arteries showed a strong correlation with Ki-67 labeling index in well-differentiated HCC and moderately differentiated HCC (rho = 0.673, p < 0.0001) and a moderate inverse correlation with Ki-67 labeling index in poorly differentiated HCC (rho = -0.540, p = 0.0185). CONCLUSION In the late stage of HCC development, the arterial blood supply significantly decreases as the histologic grade progresses.