Miracle-dz/UniFAR-FTUs huggingface dataset:
Toward a Common Framework for the Design of Soft Robotic Manipulators with Fluidic Actuation

Abstract Soft robotic manipulators with fluidic actuation are devices with easily deformable structures that comprise a set of chambers that can be pressurized to achieve structural deflection. These devices have experienced a rapid development in recent years, which is not least due to the advantages they offer in terms of robustness, affordability, and compliance. Nowadays, however, soft robotic manipulators are designed mostly by intuition, which complicates design improvement and hampers the advancement of the field. In this article, a general study of the design of soft robotic manipulators with fluidic actuation is presented using an analytical derivation. The study relies on a novel approach that is applicable to a general design and thus provides a common framework for the design of soft robots. In the study, two design layouts of interest are first justified, which correspond to extending and contracting devices. Design principles for each of the layouts are subsequently derived, both for planar and 3D scenarios, and considering operation to support any external loading and to provide any desired deflection. These principles are found to agree with the main design trends in the literature, although they also highlight the potential for improvement in specific aspects of the design geometry and stiffness distribution. The principles are used to identify the most suitable design for both extending and contracting devices in 2D and 3D and extract insight into their behavior. To showcase the use of these design principles, a prototypical scenario in minimally invasive surgery requiring a manipulator segment capable of bending in any direction is defined, where the objective is to maximize its lateral force. The principles are applied to determine the most suitable design. These also highlight the need for numerical analysis to optimize two design parameters. Finite element simulations are developed, and their results are reported. Among the most relevant is the fact that the cross-sectional area with pressurized fluid should be maximized and that the stiffness in the design should be selected to minimize structural stretching. The simulations yield the optimal design, which offers higher force than existing, reference ones. The simulations also provide verification for the study.
Implications of parental lifestyle changes and education level on adolescent offspring weight: a population based cohort study - The HUNT Study, Norway

Objective Obesity tends to cluster in families reflecting both common genetics and shared lifestyle patterns within the family environment. The aim of this study was to examine whether parental lifestyle changes over time, exemplified by changes in weight and physical activity, could affect offspring weight in adolescents and if parental education level influenced the relationship. Design, setting and participants The population-based cohort study included 4424 parent-offspring participants from the Nord-Trøndelag Health Study, Norway. Exposition was parental change in weight and physical activity over 11 years, and outcome was offspring weight measured in z-scores of body mass index (BMI) in mixed linear models. Results Maternal weight reduction by 2–6 kg was significantly associated with lower offspring BMI z-scores: −0.132 (95% CI −0.259 to −0.004) in the model adjusted for education. Parental weight change displayed similar effect patterns on offspring weight regardless of parents’ education level. Further, BMI was consistently lower in families of high education compared with low education in the fully adjusted models. In mothers, reduced physical activity level over time was associated with higher BMI z-scores in offspring: 0.159 (95% CI 0.030 to 0.288). Associations between physical activity change and adolescent BMI was not moderated by parental education levels. Conclusion Lifestyle changes in mothers were associated with offspring BMI; reduced weight with lower—and reduced physical activity with higher BMI. Father’s lifestyle changes, however, did not significantly affect adolescent offspring’s weight. Overall, patterns of association between parental changes and offspring’s BMI were independent of parental education levels, though adolescents with parents with high education had lower weight in general.
Mitigation of excessive fatigue associated with functional electrical stimulation

Objective. Restoration of motor function in paralyzed limbs using functional electrical stimulation (FES) is undermined by rapid fatigue associated with artificial stimulation. Typically, single electrodes are used to activate muscles with FES. However, due to the highly distributed branching of muscle nerves, a single electrode may not be able to activate the entire array of motor axons supplying a muscle. Therefore, stimulating muscle with multiple electrodes might enable access to a larger volume of muscle and thereby reduce fatigue. Approach. Accordingly, we compared the endurance times that ankle dorsiflexion could be sustained at 20% maximum voluntary force using feedback controlled stimulation (25 Hz) of human tibialis anterior (TA) using one or four percutaneous intramuscular electrodes. In addition, we measured endurance times in response to direct stimulation of the nerve supplying TA and during voluntary contraction. In all sessions involving electrical stimulation, an anesthetic nerve block proximal to the site of stimulation was used to isolate the effects of stimulation and alleviate discomfort. Main results. Endurance time associated with stimuli delivered by a single intramuscular electrode (84 ± 19 s) was significantly smaller than that elicited by four intramuscular electrodes (232 ± 123 s). Moreover, endurance time in response to nerve stimulation (787 ± 201 s) was not significantly different that that produced during voluntary contraction (896 ± 272 s). Significance. Therefore, excessive fatigue associated with FES is probably due to the inability of conventional FES systems to enlist the full complement of motor axons innervating muscle and can be mitigated using multiple electrodes or nerve-based electrodes.
DAS PALAVRAS E DA MÚSICA: INTERSECÇÕES NA OBRA DE FERNANDA DE CASTRO

In this research, the involvement of the author and poet Fernanda de Castro (1900-1994) in musical creation is investigated. Drawing on the concept of sociability, this article discusses the context of her artistic output in music during the Estado Novo regime in Portugal. This output is identified, described, and characterized, and an analysis of the associated intersection between music, text, and gender is proposed.
An Application of Network Science to Phonological Sequence Learning in Children With Developmental Language Disorder.

Purpose Network science has been a valuable tool in language research for investigating relationships between complex linguistic elements but has not yet been applied to sound sequencing in production. In the present work, we used standard error-based accuracy and articulatory kinematic approaches as well as novel measures from network science to evaluate variability and sequencing errors in speech production in children with developmental language disorder (DLD; aka specific language impairment). Method Twelve preschoolers with DLD and 12 age-matched controls participated in a 3-day novel word learning study. Transcription and articulatory movement data were collected to measure accuracy and variability of productions, and networks of speech productions were generated to analyze syllable co-occurrence patterns. Results Results indicated that children with DLD were less accurate than children with typical language at the segmental level. Crucially, these findings did not align with performance at the articulatory level, where there were no differences in movement variability between children with DLD and those with typical language. Network analyses revealed characteristics that were not captured by standard measures of phonetic accuracy, including a larger inventory of syllable forms, more connections between the forms, and less consistent production patterns. Conclusions Network science provides significant insights into phonological learning trajectories in children with DLD and their typically developing peers. Importantly, errors in word production by children with DLD do not surface as a result of weakness in articulatory control. Instead, results suggest that speech errors in DLD may relate to deficits in sound sequencing.
Discriminative Learning of Similarity and Group Equivariant Representations

One of the most fundamental problems in machine learning is to compare examples: Given a pair of objects we want to return a value which indicates degree of (dis)similarity. Similarity is often task specific, and pre-defined distances can perform poorly, leading to work in metric learning. However, being able to learn a similarity-sensitive distance function also presupposes access to a rich, discriminative representation for the objects at hand. In this dissertation we present contributions towards both ends. In the first part of the thesis, assuming good representations for the data, we present a formulation for metric learning that makes a more direct attempt to optimize for the k-NN accuracy as compared to prior work. We also present extensions of this formulation to metric learning for kNN regression, asymmetric similarity learning and discriminative learning of Hamming distance. In the second part, we consider a situation where we are on a limited computational budget i.e. optimizing over a space of possible metrics would be infeasible, but access to a label aware distance metric is still desirable. We present a simple, and computationally inexpensive approach for estimating a well motivated metric that relies only on gradient estimates, discussing theoretical and experimental results. In the final part, we address representational issues, considering group equivariant convolutional neural networks (GCNNs). Equivariance to symmetry transformations is explicitly encoded in GCNNs; a classical CNN being the simplest example. In particular, we present a SO(3)-equivariant neural network architecture for spherical data, that operates entirely in Fourier space, while also providing a formalism for the design of fully Fourier neural networks that are equivariant to the action of any continuous compact group.
Types of Fireballs (Extended Version)

The good properties of Plotkin's call-by-value lambda-calculus crucially rely on the restriction to weak evaluation and closed terms. Open call-by-value is the more general setting where evaluation is weak but terms may be open. Such an extension is delicate, and the literature contains a number of proposals. Recently, Accattoli and Guerrieri provided detailed operational and implementative studies of these proposals, showing that they are equivalent from the point of view of termination, and also at the level of time cost models. This paper explores the denotational semantics of open call-by-value, adapting de Carvalho's analysis of call-by-name via multi types (aka non-idempotent intersection types). Our type system characterises normalisation and thus provides an adequate relational semantics. Moreover, type derivations carry quantitative information about the cost of evaluation: their size bounds the number of evaluation steps and the size of the normal form, and we also characterise derivations giving exact bounds. The study crucially relies on a new, refined presentation of the fireball calculus, the simplest proposal for open call-by-value, that is more apt to denotational investigations.
Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslink

Abstract DNA interstrand crosslinks (ICLs) covalently join opposing strands, blocking both replication and transcription, therefore making ICL-inducing compounds highly toxic and ideal anti-cancer agents. While incisions surrounding the ICL are required to remove damaged DNA, it is currently unclear which endonucleases are needed for this key event. SNM1A has been shown to play an important function in human ICL repair, however its suggested role has been limited to exonuclease activity and not strand incision. Here we show that SNM1A has endonuclease activity, having the ability to cleave DNA structures that arise during the initiation of ICL repair. In particular, this endonuclease activity cleaves single-stranded DNA. Given that unpaired DNA regions occur 5′ to an ICL, these findings suggest SNM1A may act as either an endonuclease and/or exonuclease during ICL repair. This finding is significant as it expands the potential role of SNM1A in ICL repair.
Osteopathic Manipulative Treatment Effect on Pain Relief and Quality of Life in Oncology Geriatric Patients: A Nonrandomized Controlled Clinical Trial

Purpose: The aim of present study was to study the effect of osteopathic manipulation on pain relief and quality of life improvement in hospitalized oncology geriatric patients. Methods: A nonrandomized controlled clinical trial was performed in the Oncology Rehabilitation Unit, Milan, Italy, from September 2015 to March 2016. Twenty-three older cancer patients were enrolled and allocated in 2 experimental groups: the study group (OMT group, N = 12) underwent osteopathic manipulative treatment in addition to physiotherapy, and the control group (PT group, N = 12) underwent only physiotherapy. At enrollment (T0), 24 recruited oncology patients completed the sociodemographic forms and were evaluated for pain intensity and quality of life by an external examiner. All patients were revaluated every week (T1, T2, T3, and T4) for pain intensity and at the end of the study treatment (T4) for quality of life. A standard level of significance was set at α < . 05. Results: The 2 groups did not significantly differ in age (P = .682), body mass index (P = .413), or gender (P = 1). The osteopathic manipulative treatment added to physiotherapy produced a significant reduction in Numeric Rating Scale (NRS) scores both at T2 (P = .004) and T4 (P = .002). The difference in quality of life improvements between T0 and T4 was not statistically significant. NRS improved in the PT group at T4. Between-group analysis of NRS and quality of life with the Mann-Whitney test did not show any significant difference between the 2 treatments. Conclusions: Our study showed a significant improvement in pain relief and a nonsignificant improvement in quality of life in hospitalized geriatric oncology patients during osteopathic manipulative treatment. Trial Registration: Protocol registered on Clinicaltrials.gov (NCT03142386).
Emergency department crowding: A systematic review of causes, consequences and solutions

Background Emergency department crowding is a major global healthcare issue. There is much debate as to the causes of the phenomenon, leading to difficulties in developing successful, targeted solutions. Aim The aim of this systematic review was to critically analyse and summarise the findings of peer-reviewed research studies investigating the causes and consequences of, and solutions to, emergency department crowding. Method The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. A structured search of four databases (Medline, CINAHL, EMBASE and Web of Science) was undertaken to identify peer-reviewed research publications aimed at investigating the causes or consequences of, or solutions to, emergency department crowding, published between January 2000 and June 2018. Two reviewers used validated critical appraisal tools to independently assess the quality of the studies. The study protocol was registered with the International prospective register of systematic reviews (PROSPERO 2017: CRD42017073439). Results From 4,131 identified studies and 162 full text reviews, 102 studies met the inclusion criteria. The majority were retrospective cohort studies, with the greatest proportion (51%) trialling or modelling potential solutions to emergency department crowding. Fourteen studies examined causes and 40 investigated consequences. Two studies looked at both causes and consequences, and two investigated causes and solutions. Conclusions The negative consequences of ED crowding are well established, including poorer patient outcomes and the inability of staff to adhere to guideline-recommended treatment. This review identified a mismatch between causes and solutions. The majority of identified causes related to the number and type of people attending ED and timely discharge from ED, while reported solutions focused on efficient patient flow within the ED. Solutions aimed at the introduction of whole-of-system initiatives to meet timed patient disposition targets, as well as extended hours of primary care, demonstrated promising outcomes. While the review identified increased presentations by the elderly with complex and chronic conditions as an emerging and widespread driver of crowding, more research is required to isolate the precise local factors leading to ED crowding, with system-wide solutions tailored to address identified causes.
Özel Eğitim Öğretmen Adaylarının Öğretmen Özyeterlik Düzeyleri ve Öğretmenlik Mesleğine Yönelik Tutumları

Bu calismanin amaci, ozel egitim ogretmen adaylarinin ogretmen ozyeterlik duzeyleri ile ogretmenlik meslegine yonelik tutumlarini cesitli degiskenler acisindan incelemektir. Arastirmanin calisma grubunu 2013-2014 egitim ogretim yili bahar doneminde Ondokuz Mayis Universitesi Egitim Fakultesi Ozel Egitim Bolumunde 4.sinifta okumakta olan toplam 129 ogrenci olusturmaktadir. Ozel egitim ogretmen adaylarinin ozyeterlik algi duzeylerini belirlemeye yonelik “Ogretmen Ozyeterlik Olcegi” ve ogretmenlik meslegine yonelik tutumlarini belirlemek icin, “Ogretmenlik Meslegine Yonelik Tutum Olcegi” kullanilmistir. Arastirmanin sonucunda, ozel egitim ogretmen adaylarinin ozyeterlik duzeyleri ile ogretmenlik meslegine yonelik tutumlari arasinda orta duzeyde anlamli bir iliski oldugu; Zihin Engelliler ogretmen adaylarinin ozyeterlik algisinin Isitme Engelliler ogretmen adaylarindan daha yuksek oldugu, bayan ogretmen adaylarinin ve akademik basarisi daha yuksek olan ogretmen adaylarinin meslege yonelik tutumlarinin ise daha olumlu oldugu bulunmustur. Elde edilen bulgular ilgili alanyazin isiginda tartisilmistir.
Transcription factors Rv0081 and Rv3334 connect the early and the enduring hypoxic response of Mycobacterium tuberculosis

ABSTRACT The ability of Mycobacterium tuberculosis (M. tb) to survive and persist in the host for decades in an asymptomatic state is an important aspect of tuberculosis pathogenesis. Although adaptation to hypoxia is thought to play a prominent role underlying M. tb persistence, how the bacteria achieve this goal is largely unknown. Rv0081, a member of the DosR regulon, is induced at the early stage of hypoxia while Rv3334 is one of the enduring hypoxic response genes. In this study, we uncovered genetic interactions between these two transcription factors. RNA-seq analysis of ΔRv0081 and ΔRv3334 revealed that the gene expression profiles of these two mutants were highly similar. We also found that under hypoxia, Rv0081 positively regulated the expression of Rv3334 while Rv3334 repressed transcription of Rv0081. In addition, we demonstrated that Rv0081 formed dimer and bound to the promoter region of Rv3334. Taken together, these data suggest that Rv0081 and Rv3334 work in the same regulatory pathway and that Rv3334 functions immediately downstream of Rv0081. We also found that Rv3334 is a bona fide regulator of the enduring hypoxic response genes. Our study has uncovered a regulatory pathway that connects the early and the enduring hypoxic response, revealing a transcriptional cascade that coordinates the temporal response of M. tb to hypoxia.
Vector Control, Pest Management, Resistance, Repellents Impact of Wearing and Washing/Drying of Permethrin- Treated Clothing on Their Contact Irritancy and Toxicity for Nymphal Ixodes scapularis (Acari: Ixodidae) Ticks

Permethrin-treated clothing is available as consumer products to prevent bites by tick and insect pests. We used bioassays to examine the impact of wearing and washing/drying of permethrin-treated shirts, pants, and socks, and wearing of treated shoes, on their contact irritancy and toxicity for nymphal Ixodes scapularis Say (Acari: Ixodidae) ticks, the primary vectors in the eastern United States of the causative agents of Lyme disease, human anaplasmosis, and human babesiosis. Pristine permethrin-treated clothing displayed strong contact irritancy and toxicity toward I. scapularis nymphs, with 0–30% of ticks across clothing types and tick sources displaying normal movement 1 h after forced contact for 30–120 s with treated textile. Following 16 d of wear and 16 rounds of machine washing and drying, we recorded reduced concentrations (by 50–90%) of permethrin, compared with pristine treated clothing, from shirts, pants, and socks. This loss of permethrin was associated with reduced contact irritancy and toxicity for ticks after forced contact with worn and washed/dried treated clothing: 31–67% of ticks displayed normal movement 1 h after contact. Nevertheless, the worn and washed/dried treated clothing was still superior to nontreated textile, for which 90–100% of ticks displayed normal movement. Treated shoes, which were worn but not washed, remained as toxic to the ticks as pristine treated shoes. We caution that these laboratory bioassay results should not be interpreted as being directly indicative of the outcome of using washed/worn permethrin-treated clothing in daily life. Although wear and washing/drying did reduce the irritancy and toxicity of permethrin-treated clothing for I. scapularis nymphs more than we had expected, the remaining effect might still reduce the risk of tick bites in a real-life scenario.
Comparison of Highly and Weakly Virulent Dickeya solani Strains, With a View on the Pangenome and Panregulon of This Species

Bacteria belonging to the genera Dickeya and Pectobacterium are responsible for significant economic losses in a wide variety of crops and ornamentals. During last years, increasing losses in potato production have been attributed to the appearance of Dickeya solani. The D. solani strains investigated so far share genetic homogeneity, although different virulence levels were observed among strains of various origins. The purpose of this study was to investigate the genetic traits possibly related to the diverse virulence levels by means of comparative genomics. First, we developed a new genome assembly pipeline which allowed us to complete the D. solani genomes. Four de novo sequenced and ten publicly available genomes were used to identify the structure of the D. solani pangenome, in which 74.8 and 25.2% of genes were grouped into the core and dispensable genome, respectively. For D. solani panregulon analysis, we performed a binding site prediction for four transcription factors, namely CRP, KdgR, PecS and Fur, to detect the regulons of these virulence regulators. Most of the D. solani potential virulence factors were predicted to belong to the accessory regulons of CRP, KdgR, and PecS. Thus, some differences in gene expression could exist between D. solani strains. The comparison between a highly and a low virulent strain, IFB0099 and IFB0223, respectively, disclosed only small differences between their genomes but significant differences in the production of virulence factors like pectinases, cellulases and proteases, and in their mobility. The D. solani strains also diverge in the number and size of prophages present in their genomes. Another relevant difference is the disruption of the adhesin gene fhaB2 in the highly virulent strain. Strain IFB0223, which has a complete adhesin gene, is less mobile and less aggressive than IFB0099. This suggests that in this case, mobility rather than adherence is needed in order to trigger disease symptoms. This study highlights the utility of comparative genomics in predicting D. solani traits involved in the aggressiveness of this emerging plant pathogen.