Miracle-dz/UniFAR-FTUs huggingface dataset:
A Systematized Review of Nurses’ Perceptions of Medication Errors Contributing Factors in Developing Countries

Introduction: Nurses are a main factor in maintaining the safety of a patient. Nurses are the main component and are indeed at the front of dispensing medicines to patients; they also have a responsibility to maintain the patient’s safety. Objective: This systematized review intends to review studies that assess and explore nurses’ attitudes and perceptions of medication errors in developing countries within the Middle East region, thereby contributing to knowledge regarding medication error risk. Methodology: a database search has been conducted for studies related to the research question that has been formulated using PEO framework, the database includes: MEDLINE and CINAHL EBSCO and OVID, NICE, Science Direct and ERIC. The reference lists and bibliographies were also analyzed, all the studies founded during the search process were assessed according to predefine inclusion and exclusion criteria. 10 studies (6 quantitative studies, 3 qualitative and 1 which used mixed methods) were chosen and were included in this review. Result: The studies assessed in this review were noted to have moderate to strong quality. The review found a range of factors that contribute to medication error, including both human and environmental factors. Among the contributing factors that most frequently mentioned inthis review were insufficient pharmacological knowledge, fatigue and overwork, communication breakdown, inadequate staff training, and high patient-to-nurse ratio. Conclusion and Recommendation: It would behave Saudi Arabia and neighboring countries to invest attention in this topic. Particularly advised would be additional theoretically focused research to determine the causes of medication errors.
RELIABILITY OF TESTS FOR MEASURING ISOMETRIC FORCE OF THE MUSCLES WHILE SHOOTING IN BASKETBALL

The aim of this research is to determine the isometric muscle force (IMF) of the dominant arm in the position directly before the basketball shooting, and to check test reliability. Fifteen male basketball players (age 17±1 years, body height 185.60±6.31 cm; body mass 78.07±8.56 kg) with at least 5 years of the basketball experience, were subjected to a muscle manual test (shoulder flexion, elbow extension and wrist flexion), using a hand-held dynamometry (HDD). High values of relative reliability are reported in each of the tests (0.79, 0.82, and 0.84, respectively). Cronbach's alpha coefficient indicated the values of reliability during shoulder flexion, elbow extension and wrist flexion range from 0.779, 0.807, 0.848 respectively, presenting the results of the reliability as high. The applied F test provides a statistically significant Intraclass Correlation Coefficient at the level of p<0.001 for each test. Absolute reliability is displayed through the coefficient of variation, and meets the criterion which ranged between 5.6 to 7.8%. HDD was determined to be reliable in terms of measuring IMF.
Prevalence of non-alcoholic fatty liver disease in patients with prediabetes

Background. Diabetes mellitus (DM) is one of the largest global health emergencies. Prediabetes is an early stage in hyperglycemia continuum where individual is at an increased risk for development of DM. NAFLD represents a range of liver disorders characterized by hepatic steatosis or accumulation of fat in the liver cells in the absence of excessive alcohol consumption, viral or drug related etiologies. However, not many studies have been conducted to study the prevalence of non-alcoholic fatty liver disease (NAFLD) in persons with prediabetes. This study is an endeavor in that direction. Materials and methods. This was a cross-sectional observational study. 100 prediabetic patients, fulfilling the criteria as under, were included in the study over a period from November 2017 to March 2019, after informed consent. Investigations carried out on the patients included baseline biochemical parameters like complete hemogram, fasting plasma glucose, liver function tests, kidney function tests, serum electrolytes and specialized investigations like HbA1c, 2-hour-OGTT and serum insulin levels. Results. The study included 38 males and 62 females, with the median age for the study population being 46 years. The mean BMI was found to be 24.29 ± 3.98 kg/m2, and the mean waist circumference was found to be 81.26 ± 8.71 cm. A significant association was found between the level of fatty echotexture on ultrasound and BMI (p = 0.003), and gender (0.05). 30 % population was found to be insulin sensitive, 22 % was found to be depicting early insulin resistance and 48 % had significant insulin resistance. There was a statistically significant correlation between ultrasound and fibroscan findings. A significant statistical correlation was found between HOMA IR and level of fatty echotexture on ultrasound, as well as median liver stiffness on fibroscan. Conclusions. We found a significant correlation between insulin resistance and presence of NAFLD. Also, significant associations were observed between various demographic characteristics and grade of steatosis. There is a need to undertake further studies on a larger scale, to substantiate the observations of this study. This understanding is expected to go a long way in generating awareness and optimizing public health strategies.
Significance of OCT3/SLC22A3, Organic Cation Transporter 3, Expression for the Cytotoxic Effect of Oxaliplatin in Colorectal Cancer

The effect of oxaliplatin against colorectal cancer is superior to that of cisplatin, but the molecular mechanism(s) involved is not clear. We previously found that oxaliplatin, but not cisplatin, was transported by human (h) and rat OCT3/SLC22A3, organic cation transporter 3. In the present study, we examined whether hOCT3 was significantly involved in the oxaliplatin-induced cytotoxicity and accumulation of platinum in colorectal cancer. The level of hOCT3 mRNA in the colon was 9.7-fold higher in cancerous than normal tissues in six Japanese patients (P=0.0247). results of this study, that the cytotoxicity of oxaliplatin depended on hOCT3 expression, may be expanded to include the effectiveness in clinical cases.
Is SARS-CoV-2 Spike glycoprotein impairing macrophage polarization via α7-nicotinic acetylcholine receptors?

The innate immune cells play an important role in handling early infections, and can eliminate them completely up to a certain threshold. Beyond that threshold they take up their role in “The Resolution of Inflammation”. The recognition of the SARS-CoV-2 antigen triggers an eicosanoid storm and initiates a robust inflammatory response. This establishes a positive feedback loop which develops into a sustained cytokine storm which interferes with the activation of adaptive immune cells. The mechanism of this interaction, and hence the pathogenesis of the virus with the immune system, is yet to be determined. In silico studies predict a direct SARS-CoV-2 spike glycoprotein interaction with nicotinic acetylcholine receptors, which could impair macrophage function and initiate the cascade of events described above. We here, add to the hypothesis that immune dysregulation can be caused by the interaction of the SARS-CoV-2 spike glycoprotein via a cryptic epitope with the α7-nAChR in Type-1 macrophages, discuss its implications for the treatment of COVID-19 patients, and present better prospects for the design and dissemination of more effective vaccines and their importance.
The Concurrent Effects of IFRS Mandate and Formal Institutional Quality on the Aftermarket Performance of IPO Firms in Emerging Countries

This paper provides the first empirical investigation seeking to find whether International Financial Reporting Standards (IFRS) mandate, changes in the quality of formal institutions, or, the concurrent effect of these two elements can explain the ongoing phenomenon of the aftermarket performance difference of Initial Public Offerings (IPO) firms. We perceive little awareness of the concurrent effect of IFRS mandate and the quality of formal institutions in emerging countries, although these nations account for more than half of the IFRS mandating countries. We employ numerous Difference-in-Differences (DiD) models utilizing reliable IPO and formal institutional data for Saudi Arabia from 2005 to 2017. Our empirical results show that the absence of IFRS influence in the aftermarket performance of IPO firms led us to posit that the quality of formal institutions is the key player in influencing long-term performance of IPO firms in Saudi Arabia. We uncover evidence showing that an improvement in formal institutional quality increases the long-term performance of IPO firms. We find no evidence of a concurrent effect of changes in formal institutional quality and IFRS mandate on the aftermarket performance of IPO firms. Our results show that what does really matter in relation to the aftermarket performance of IPO firms in Saudi Arabia, are the enhancements in the level of formal institutional quality. Our results provide some important implications for IFRS-IPO research.
Assessment of Perceived Healthcare Access in a Rural Community in Rizal: A Cross-sectional Study

Background: Access to health care is considered a basic right and integral to human life. However, this still remains a challenge especially in developing countries where the majority of the poor reside and suffer from a disproportionate amount of disease. The study determined the six key components of health care access: approachability, availability, accessibility, affordability, acceptability, and accommodation, as perceived by a rural community in Taytay, Rizal, Philippines. Methods: This descriptive-cross sectional study included a convenience sample of 62 participants. The Perceived Access to Health Care Instrument was utilized. Frequency, percentage, mean, standard deviation, and univariate linear regression were used to analyze the data. Results: The study revealed that health care access in terms of approachability was rated as good, whereas availability was rated as good, and accessibility was rated as fair. On the other hand, the affordability of health care services was rated as good, the acceptability was rated as good while the accommodation was rated as fair. It was also revealed that none of the demographic profiles significantly predicted the perceived access to health care Conclusion: Assessment of health care access is an important measure of health care equity and despite several factors previously shown to affect health care access, the results of this study showed that the participants have good access to health care in their community.
Investigation of the change in the biological structure of the tumor in metastatic breast cancer

Objective: When metastasis develops in some breast cancer patients, hormone receptors (HR) and Human Epidermal Growth Factor-2 (Her-2) status can change and the tumor alters its character. We tried to determine the rate of these changes in tumor biology in 110 patients that we followed in our clinic and performed the change of the biopsy from the metastatic site (re-bx). We aimed to determine the biological changes of tumors and, contribute to the literature by examining the relationship of these changes with the adjuvant endocrine treatments (ET) or chemotherapy type (CT). Material and Methods: We included 110 metastatic breast cancer patients in our study. These patients had previously completed their local treatments followed by CT, and those with positive HR completed ET. After the first metastasis developed in the patients, we performed metastasectomy or biopsy from the metastatic site. Results: The median ki-67 value was 25% at the time of primary diagnosis and 30% in re-bx. 20.9% of patients estrogen receptor (ER), 31.8% of patients progesterone receptor (PR) and 26.3% of patients Her-2 changed when metastasis developed. Conclusions: We found that the metastatic tumor has more aggressive properties than the primary tumor. Adjuvant chemotherapy and endocrine treatments or the location of metastasis did not make a significant difference in tumor biology.
ANTIBACTERIAL ACTIVITY OF Gynura procumbens LEAF EXTRACT AGAINST Pseudomonas aeruginosa IN VITRO

Intensification of fish farming has caused various impacts, for example diseases in fish. One of the diseases in fish is a bacterial disease. The use of natural compounds as an antimicrobial agents, which is relatively safe and effective, is a strategy to treat the disease. The aim of this study was to evaluate the antibacterial activity of Gynura procumbens leaf extract against Pseudomonas aeruginosa. Antibacterial activity test was done by using paper disc diffusion. The variations on the test paper disc method used were based on the concentration difference of Gynura procumbens leaf extract such as: A (250 ppm), B (500 ppm), C (750 ppm), D (1.000 ppm) dan E (1.250 ppm). The results showed Gynura procumbens leaf extract produced antibacterial compounds which inhibited the growth of the bacteria. Effective antibacterial activity was detected in concentration of 1.250 ppm with inhibition zone diameter of 11,01 ± 0,59 mm. It can be concluded that Gynura procumbens leaf extract may contribute in controlling the spread of bacterial diseases in fish farming, particularly caused by Pseudomonas aeruginosa.
Brain Signal Based Driver Drowsiness Prediction

Drowsiness has been one of the leading causes of injuries or fatalities in vehicle accidents. Therefore, in this research work, it is proposed to develop an adaptive heavy vehicle driver fatigue and alertness model based on EEG frequency bands by combining signal processing algorithms and soft computing techniques such as Neuro-fuzzy algorithm to estimate the driver cognitive state while driving a vehicle in a virtual reality (VR)-based dynamic simulator under monotonous driving environment. Thus in this research, it is proposed to minimize the number of features using soft computing techniques and classification using non-linear supervised classification algorithms. The proposed adaptive model identifies the discrimination between the driver's level of fatigue by recognizing whether the driver is fatigue due to task-induced factors or attitude/behaviour using the brain responses, then the level of fatigue is related with sleepiness (i.e. level of alertness towards driving). Further, the adaptive model can be utilized to alert drivers and regulators in optimizing the properties of the interface systems in identifying potential catastrophe. The proposed system alerts the driver during fatigue/drowsiness according to the recognition of cognitive state and produce the fatigue index and level of alertness. The proposed system also helps the driver to be more attentive and intuitive to prevent from fatal road accidents.
Peramalan Data Indeks Harga Konsumen Berbasis Time Series Multivariate Menggunakan Deep Learning

Multivariate Time Series based forecasting is a type of forecasting that has more than one criterion changes from time to time that it can forecast based on historical patterns of data sequences. The Consumer Price Index (CPI) issued regularly every month by the Statistics Indonesia calculated based on data observations. This study is a development of previous research that only used on type of algorithm to predict CPI value resulting poor of accuracy due to lack of architecture variations testing. This study developed a CPI forecasting model with a new approach about using several types of deep learning algorithms, namely LSTM, Bidirectional LSTM, and Multilayer Perceptron with architectural variations of the number of neurons and epochs. Furthermore, this study adapt ADDIE model of Research and Development method. Based on the results, the best accuracy is obtained from the LSTM Bidirectional with 10 neurons and 2000 epoch resulting 3,519 of RMSE value. Meanwhile, based on the average RMSE value for the whole test, LSTM gets the smallest average of RMSE followed Bidirectional LSTM and Multilayer Perceptron with the RMSE value 4,334, 5,630, 6,304 respectively.
Complete response of metastatic cervical adenocarcinoma treated with chemoradiotherapy followed by pembrolizumab: A case report

Introduction: Metastatic adenocarcinoma of the uterine cervix is challenging to treat, particularly if there is persistent disease following surgery and chemoradiotherapy. In recent years, advances in checkpoint inhibitor-based immunotherapy have shown promise in patients in a variety of cancers. Only limited information is available concerning treatment of cervical adenocarcinoma with checkpoint inhibitors. Case Report: This case report details a patient with metastatic cervical adenocarcinoma with persistent disease following surgical resection. Subsequent treatment with cisplatin, paclitaxel, and bevacizumab therapy with concurrent radiotherapy resulted in a partial response. The patient was subsequently treated with pembrolizumab. After 3 cycles of treatment the patient achieved a stable radiologic complete remission, which continues after treatment discontinuation. Conclusion: This result suggests that chemoradiotherapy with either concurrent or sequential administration of a PD-1 antibody, such as pembrolizumab, may have significant activity as treatment of metastatic or unresectable cervical adenocarcinoma. Further prospective clinical testing appears warranted. Wolfram Samlowski1,2, Mark Chang2, Raul Meoz3, Amin Hedayat4 Affiliations: 1Comprehensive Cancer Centers of Nevada, Las Vegas, NV, USA; University of Nevada, Reno, NV, USA; 2University of Nevada Las Vegas (UNLV), Las Vegas, NV, USA; 3Comprehensive Cancer Centers of Nevada, Las Vegas, NV, USA; 4Associated Pathologists Chartered Laboratories, American Melanoma Institute, University of Nevada Las Vegas (UNLV), Las Vegas, NV, USA. Corresponding Author: Wolfram Samlowski, MD, Comprehensive Cancer Centers of Nevada, 9280 W. Sunset Rd, Suite 100, Las Vegas, NV 89148, USA; Email: wsamlowski1@gmail.com Received: 19 September 2020 Accepted: 02 February 2021 Published: 10 March 2021 PEER REVIEWED | OPEN A CE S
The State, Institutions, and the Challenge of Development in Bangladesh

In order to understand the challenges of development in Bangladesh, this paper attempts to examine the linkages between the state, institutional effectiveness, and the problems of development. In doing so, the paper systematically reviews extensive literature on the state, institutional effectiveness, and the challenges of development in Bangladesh focusing issue of governance. Considering the fact that the state is an important political actor, this paper first attempts to outline the understandings of the state. In other words, the paper does not intend to define the state but rather endeavour to show the understanding of the state. The paper then critically examines the degree of state intervention in promoting growth and development, and the nature of the Bangladesh state. And finally, it attempts to recount conventional accounts of the Bangladesh state and show the challenges of governance in promoting development under the auspices of the state.
Haulier Value Creation in Supply Chains

Purpose Road transport is a dynamic sector with market changes because of liberalization and increasing demand of transport and logistics services. Shippers’ supply chain objectives of low costs and agility and a demanding operating environment due to, for example, congestion is challenging. Haulier competitiveness, however, resides in knowledge, technology and networks so the purpose of this study is to develop a conceptualisation of how these capabilities are deployed and make up effective value propositions for customers. Design/methodology/approach Two case studies of value proposition development are analysed for objectives of strategic development. Findings Haulier competitiveness is not a static but a result of resource deployment. From the strategy-as-practice perspective collaborators’ and customers’ resources are considered potentials for emergent strategies and learning for value-creation. Research limitations/implications The usefulness of the conceptual apparatus lies in understanding strategic development as a result of capability deployment rather than managerial decision making per se. Practical implications Both hauliers and shippers are able to improve value creation from increased understanding of capability deployment. Original/value This research shows that innovation of transport companies’ (hauliers’ and other types of logistics providers’) value propositions drives competitiveness. The strategy-as-practice approach is applied as the theoretical lens for understanding and developing strategic outcomes of transport and logistics provision and supply chain value creation.
From auction theory to market design: Paul Milgrom and Robert Wilson’s contributions to Economics

The 2020 Economics Nobel Prize was awarded to Paul Milgrom and Robert Wilson. Both laureates have made seminal, crucial contributions to auction theory and practical market design. Here, we briefly describe those contributions and their significance within the general context of auction theory and practice. We also review the laureates’ substantial and highly influential work in other areas of economics.
A new ranking function of triangular neutrosophic number and its application in integer programming

Real humankind problems have different sorts of ambiguity in the creation, and amidst them, one of the significant issues in solving the integer linear programming issues. In this commitment, the conception of aggregation of ranking function has been focused on a distinct framework of reference. Here, we build up another framework for neutrosophic integer programming issues having triangular neutrosophic numbers by using the aggregate ranking function. To legitimize the proposed technique, scarcely numerical analyses are given to show the viability of the new model. At long last, conclusions are talked about.
Review of Biosynthesis Silver Nanoparticles by Microbiology

Nanotechnology is a multidisciplinary field that evolved within the past few decades and played a substantial role in the environment, industry, agriculture, and pharmacology. Nanoparticles are generally classified based on their dimensionality, morphology, composition, uniformity, and agglomeration. The shape, and morphology of nanoparticles play an essential role in their functionality and toxic effect on the environment and humans. In this review, we discuss the biosynthesis of nanoparticles from microbes. For the biological synthesis of nanoparticles, microbes have been exploited all over the globe. Microbes like bacteria, fungi, and yeasts are mostly preferred for nanoparticles (NPs) synthesis because of their fast growth rate, easy cultivation, and their ability to grow at ambient conditions of temperature, pH, and pressure. Applications of Nanoparticles is a field of research with tremendous prospects for the improvement of the diagnosis and treatment of human diseases. Microbial nanoparticles are found to have vigorous antibacterial activities. The nanoparticles' efficiency is probably due to their larger surface area for enhanced interaction with the micro-organisms. Nanoparticles adhere to the cell membrane and further penetrate inside by interacting with DNA, thereby interfering with the replication process or may attack the respiratory chain of pathogens. A similar bactericidal mechanism of silver nanoparticles obtained from endophytic bacterium Bacillus cereus was observed against pathogenic bacteria like Salmonella typhi, Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus, and Pseudomonas aeruginosa.