Miracle-dz/UniFAR-FTUs huggingface dataset:
2011 ACCF/AHA Coronary Artery Bypass Graft Surgery Data Supplements Data Supplement 1. Anesthetic Considerations Author Drug Number of Patients Number of patients with ≥1 SAE (%) RR (95% CI) P-Value Mortality Number of Patients (%) RR

Ott et. al. 2003 (1) Standard Care 151 15 (9.9) 0 (0) 4 (2.6) 0 (0) Parecoxib/valdecoxib 311 59 (19.0) 0.015 4 (1.3) 0.31 17 (5.4) 10 (3.2) 0.035 Nussmeier et al. 2005 (2) Placebo 560 22 (4.0) 1 (0.2) 3 (0.5) 16 (2.9) Placebo+Valdecoxib 556 40 (7.4) 1.9 (1.1 to 3.2) 0.02 3 (0.6) 3.0 (0.3 to 29.3) 0.31 6 (1.1) 2.0 (0.5 to 8.1) 0.31 27 (5.0) 1.7 (0.9 to 3.3) 0.08 Parecoxib/valdecoxib 555 40 (7.4) 1.9 (1.1 to 3.2) 0.02 4 (0.7) 4.1 (0.5 to 36.4) 0.18 11 (2.0) 3.7 (1.0 to 13.5) 0.03 20 (3.7) 1.3 (0.7 to 2.5) 0.48 Both COX-2 Groups 1,088 1,088 (7.4) 2.9 (0.8 to 9.9) 0.08 7 (0.6) 3.6 (0.4 to 29.1) 0.2 17 (1.6) 2.9 (0.8 to 9.9) 0.08 47 (4.3) 1.5 (0.8 to 2.7) 0.15 CI indicates confidence interval; COX-2; cyclooxygenase-2 inhibitors; CV, cardiovascular; N, number of patients; RR, relative risk; and SAE, serious adverse events.
Effects of Physiological Levels of Estrogen on Coronary Vasomotor Function in Postmenopausal Women

BACKGROUNDEstrogen replacement therapy has been associated with a reduction in cardiovascular events in postmenopausal women. One of the mechanisms responsible may be a beneficial effect of estrogen on coronary vascular function. We therefore studied the short-term effects of estrogen on coronary artery dimensions and microvascular resistance in postmenopausal women.METHODS AND RESULTSTwenty postmenopausal women 61 +/- 7 years old participated in this study. Seven had angiographic evidence of atherosclerosis of the left coronary artery. Coronary artery diameters were measured by quantitative coronary angiography. Blood flow velocity was measured with a Doppler wire placed in a proximal left coronary artery segment. Left coronary artery infusions of acetylcholine (range, 10(-8) to 10(-5) mol/L estimated delivered concentrations) and of adenosine (n = 18) and sodium nitroprusside (n = 10) were performed before and during concomitant continuous intracoronary infusion of 17 beta-estradiol to test endothelium-.
Patients' experiences of having their wounds treated with medical grade honey: an interpretative phenomenological analysis

A sense of desperation led to the willingness to use ‘anything’ to cure, heal and alleviate pain as described in Dot’s and Agnes’s accounts (Table 1). A holistic approach to treatment was provided by the educational support and empowerment encouraged by Leg Club® staff thus allowing participants to feel autonomous highlighted in Agnes’s and Bill’s accounts (Table 1). Moreover, the consistent and high quality care received amongst this cohort by the Leg Club® staff was illustrated and studies have shown that such practices enhance patient compliance thus resulting in better healing outcomes (Greenfield et al.,1988; Conboy et al., 2010). The lived experiences of honey to treat leg ulcers varied from positive experiences to mixed experiences to negative experiences and the two main attributes of honey included honey being a folkloric medicine and honey being a natural medicine. Participants felt comfortable when using honey in wound care as it was considered as a natural remedy that could exploit its healing properties. Furthermore, honey being used by the historical figure, Florence Nightingale provided a sense of credibility when using honey to treat wounds. Participants also expressed positive experiences by identifying the beneficial properties of honey. Conversely, honey was also identified as the source of pain as it caused a stinging and drawing sensation. The lived experiences of using honey also suggests that no one antimicrobial offers a panacea and clinicians should consider whether the patient’s wound is suitable for the particular antimicrobial treatment in question.
Psychiatric Morbidity Among Prisoners in England and Wales

My favourite scene in the film Wayne's World has the aspiring rock stars brought face to face with the real thing, in the shape of Alice Cooper, clad in leather and mascara. Overawed, their wits desert them and they can only babble: “We're not worthy, we're not worthy, we're not worthy! ”, as
Dietary Intake of Antioxidants in the Elderly People under Nursing Care: A Case–Control Study

Background: Nutrient deficiency such as antioxidants is a common problem in the elderly; it can result in different diseases such as cancer. Accordingly, assessment of the dietary intake of antioxidants is necessary to design a specific plan for solving this problem. Methods: This case–control study was conducted on 152 old people (≥60 years) with and without nursing care in nursing care centers in Isfahan, Iran, in 2017. Nutritional assessment was performed by an expert nutritionist using semi-quantitative validated Food Frequency Questionnaire. Nutrition IV software was used as food analyzer. Analysis of covariance and independent t-test were used for data analysis. Results: The mean age of the participants was 68.6 ± 4.9 and 68.9 ± 6.1 years in case and control groups, respectively, and the percentage of male/females in these groups was 46.3%/53.7% and 51.4%/48.6%, respectively. Dietary intake of energy, vitamin E, and selenium was significantly higher (P = 0.041; 0.007; 0.017) while beta-carotene intake was significantly lower in the elderly under nursing care than in the control (P = 0.002). Conclusions: The findings indicated that nursing care leads to improved intake of energy, vitamin E, and selenium, while diminished beta-carotene intake in the elderly. Intake of vitamin E, A, C, zinc, and selenium was high among elderly people with and without care, compared with the dietary reference intake. It seems that further studies are required to confirm these findings.
Pandemic Influenza Threat

The threat of a human influenza pandemic has greatly increased over the past several years with the emergence of highly virulent avian influenza viruses, notably H5N1 viruses, which have infected humans in several Asian and European countries. Previous influenza pandemics have arrived with little or no warning, but the current widespread circulation of H5N1 viruses among avian populations and their potential for increased transmission to humans and other mammalian species may afford us an unprecedented opportunity to prepare for the next pandemic threat. The US Department of Health and Human Services is coordinating a national strategy to respond to an influenza pandemic that involves multiple agencies, including the Centers for Disease Control and Prevention, the Food and Drug Administration, and the National Institutes of Health (NIH). Within NIH, the National Institute of Allergy and Infectious Diseases (NIAID) conducts basic and clinical research to develop new vaccine technologies and antiviral drugs against influenza viruses. We describe recent research progress in preparing for pandemic influenza.
IN THE PRUNE BELL Y SYNDROME

Objectives: To describe our experience with chronic ambulatory peritoneal dialysis in children with the prune belly syndrome (PBS). Design: From our peritoneal dialysis (PD) program we were able to review the medical records of 6 boys with PBS. Data were collected on potential complications such as infections, hernias, growth, and problems encountered with PD catheter insertion. Results: The ages of the 6 boys ranged from 10 months17 years. The dialysis duration was from 9-22 months, with a total of 76 patient-months on PD. There was one death, possibly as a complication of an exit-site infection. Five received a renal transplant, and 4 have functioning grafts. Peritonitis occurred once in every 10.8 patientmonths, and exit-site or tunnel infection was diagnosed every 7.6 patient-months. Four patients required PD catheter replacement because of tunnel infection in 2, persistent exit-site infection in 1, and fluid leakage in 1. Of a total of nine catheters, three were inserted using a laparoscopic technique. There were no leaks in these three; however , therewas one exit-site infection. Two patients had inguinal hernias that required surgery. Conclusion: Deficiency of abdominal musculature in PBS poses potential problems for the use of PD, in particular, catheter anchorage, exit-site healing, and leakage. In our patients the most serious complications were infections of the exit site or catheter tunnel. Our experience suggests that a laparoscopic technique may provide improved catheter placement. PD offers a potentially successful form of dialysis for patients with PBS.
Identification of the concentration of iodopovidone pleurodesis in rats for the maximal effectiveness Siçanlarda maksimum etkinlik için iodopovidon plörodezis konsantrasyonunun belirlenmesi

Amac: Bu calismada, plorodez amaci ile kullanilan iodopovidonun farkli dozlarinin etkinligi ve guvenilirligi arastirildi ve tiroid dokusundaki histopatolojik degisiklikler degerlendirildi. Ca­lis­ma­ pla­ni:­Bu deneysel calismaya alinan 38 Albino Wistar erkek sican (260-320 g, 6-8 aylik) rastgele dort gruba ayirildi. Grup 1, 2 ve 3’e sirasiyla plevra icine %1, %2 ve %4’luk konsantrasyonlarda 2 mL/kg iodopovidon, grup 4’e plevra icine serum fizyolojik verildi. Plevral yuzeyler 30. gunde makroskopik ve mikroskopik inceleme ile derecelendirildi ve tiroid dokulari histopatolojik olarak incelendi. Bul gu lar: Iodopovidon %2 ve %4’luk konsantrasyonlarda daha belirgin yapisma ve enflamatuvar yanita neden oldu. Yuzde dortluk iodopovidon kontralateral viseral plevra yuzeyinde anlamli olmayan mikroskopik degisiklere neden oldu. Hicbir grupta tiroid dokusunda hipertiroidizm bulgusu olan vakuolizasyon izlenmedi. So­nuc:­Etkili ve guvenli bir plorodez icin %2’lik iodopovidonun yeterli olacagini ve basari saglanamayan olgularda iodopovidon konsantrasyonunun %4’e yukseltilebilecegini onermekteyiz. Ancak deney sicanlar uzerinde calisilmis oldugundan, insan calismalarinda da benzer sonuclarin alinabilecegi kesinlik kazanmamistir. Anah tar soz cuk ler: Iyot; iodopovidon; plorodezis; tiroid. Background:­This study aims to investigate the efficacy and safety of different doses of iodopovidone for pleurodesis and to evaluate the histopathological changes in thyroid tissue. Methods: Thirty-eight male Albino Wistar rats (260-320 g, 6-8 months old) included in this experimental study were randomly divided into four groups. Groups 1, 2, and 3 were given 2 mL/kg intrapleural iodopovidone at concentrations of 1%, 2%, 4%, respectively, while group 4 was administered intrapleural saline. The surfaces were graded by macroscopic and microscopic examination on Day 30 and thyroid tissues were histopathologically examined. Results:­ Iodopovidone at concentrations of 2% and 4% resulted in significantly more adhesions and inflammatory response. Four percent iodopovidone produced nonsignificant microscopic changes in the contralateral visceral pleural surface. No vacuolization in thyroid tissue showing hyperthyroidism was observed in the groups. Conclusion:­We suggest that 2% iodopovidone is enough for an effective and safe pleurodesis and the concentration of iodopovidone may be raised to 4% in unsuccessful cases. However, as the study was conducted on rats, it still remains to be elucidated that the similar results can be achieved in human studies.
Sero-prevalence of anti- CMV- IgM and anti -CMV- IgG in Iraqi Aborted Women Infected with Human Cytomegalovirus in Nasiriyah city

Many viruses infections are associated with abortion as cytomegalovirus infection. CMV is almost asymptomatic there for, diagnosis depends primarily on serological tests namely Enzyme linked immunosorbent assay (ELISA) to detect immunoglobulin M and G (IgM, IgM) in serum of aborted women. This study was carried out in Bent- Al Huda hospitals for the period (April 2015 to June 2015). A number of 50 aborted women serum collected during 2015. Serum samples were collected and then tested by ELISA for detection of anti-CMV IgM and IgG antibodies. The number of abortion more incidences in second group aged (20 to30 years). CMV specific IgM antibody was detected in 3pataint (6%) of the 50 aborted women ,while the specific IgG antibody detected in high percentage 46% in 23 samples. these result was statistically significant (P<0.05) . Seropositivity results for cytomegalovirus (CMV) is highly occurrences in women with first trimester of gestation.
The Anti-Cancer Drug Supply Chain: A Coupled Production-Distribution Problem

Providing chemotherapy at home is an emerging problem, especially in France. Due to a recent French health regulation, the preparation of anticancer drugs must be performed inside a specific unit with an insulator or flow hood. This condition implies a centralized production, transportation under specific conditions, and taking into account a drug’s shelf life. In this article, we briefly present the anti-cancer drug supply chain. We then focus on the coupled production-distribution problem detailing the solution approach and the result analysis.
RISK ASSESSMENT PROGRAM FOR FETAL ANEUPLOIDIES AT THE MUNICIPAL CLINICAL EMERGENCY HOSPITAL IN TIMISOARA

Objective: To analyze the risk assessment program for fetal aneuploidies done by the Municipal Clinical Emergency Hospital Timisoara. The primary indicators are: the rate of false positive results and the detection rate. Materials and methods: A triple test determination (AFP, hCG, Free E3) and a fetal morphology ultrasound was performed on 2169 gravidas. The aneuploidy risk was assessed based on a standard mathematical formula including biochemical and ultrasound results. High risk gravidas received amniocentesis and a fetal karyotype in one of the four genetic centers in our area. The antenatal and postnatal diagnosed cases were counted. Results: The age of gravidas was 29.3+/-4.5 years (Mean+/-DS) and the gestational age at the moment of screening was 16.3+/1.1 weeks. 43 gravidas had an age-risk and 49 gravidas a biochemical risk higher than 1:100 while 184 gravidas had an age-risk and 163 gravidas a biochemical risk higher than 1:250. The biochemical risk was adapted based on second trimester ultrasound. In the evaluated cases, we performed 62 amniocentesis, from which 4 were positive: 3 Down syndrome fetuses and 1 Turner syndrome. There were one newborn with Down syndrome (due to poor doctor – patient communication). The rate of false positive cases was 2.85% and the detection rate was 80%. Conclusions: The combined assessment of aneuploidies based on age, biochemical triple test parameters and the second trimester ultrasound remains an applicable method in our system as long as not all gravidas come for screening during the first trimester of pregnancy.
STUDY OF THE EFFECTS OF ADIPOSE-TISSUE MESENCHYMAL STEM CELLS AND CONDITIONED MEDIUM ON CELL INFILTRATION IN THE BRAINS OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS C57 BL/6 MICE

Objective: This study investigated the effects of adipose-derived mesenchymal stem cells (MSCs) and conditioned medium injection on cell infiltration in the brains of an experimental C57BL/6 mice model of autoimmune encephalomyelitis (EAE). Methods: EAE was induced with myelin oligodendrocyte glycoprotein (35-55 peptides) in 20 mice. MSCs were obtained from the adipose tissue of C57BL/6 mice and cultured with Eagle’s minimum essential medium/alpha medium (DMEM) after removal of nonadherent cells. After 2 to 3 passages, 15 days after induction of EAE, 4 groups (n=5) of C57BL/6 mice were treated as follows: i) MSCs were injected intraperitoneally, ii) MSCs were injected intravenously, iii) conditioned medium was administrated intraperitoneally, and iv) the control group received no treatment. After day 60, the mice brains were removed and the effect of adipose-tissue MSCs and administration of conditioned medium was investigated. Results: Leukocyte infiltration and clinical scores were significantly reduced in animals that received MSC and conditioned medium compared to untreated animals. Body weight increased significantly in the treated groups compared to the control group. Percentage of survival also increased in the animals that received MSCs and conditioned medium as compared to the control group. Conclusion: MSCs had immunomodulatory and neurogenerative functions which reduced leukocyte infiltration and improved clinical scores in the EAE animals that received MSC and conditioned medium compared to untreated animals with EAE.
DEVELOPMENTS IN COLON SPECIFIC DRUG DELIVERY SYSTEMS-A REVIEW

Colon specific drug delivery has gained increased importance not for the treatment of local diseases associated with the colon but also as potential site for systemic delivery of therapeutic proteins and peptides. Colon is a site where both local and systemic delivery of drug can take place. Treatment could be more effective if it is possible for drug to be directly to colon. Systemic side effects can also be reduced the primary approaches to obtain colon specific delivery is based on prodrugs, pH and time dependent systems (or) microflora activated systems and have achieved limited success only. Most recently new colon – specific delivery systems are developed. These are pressure controlled colon delivery capsules, CODESTM, colon drug delivery systems based on pectin and galactomam coating, hydrogels, osmotic controlled drug delivery system, pulsincap system, time clock system, chronotropic system, enterion capsule technology. The review is aimed at understanding above pharmaceutical approaches to colon targeted drug delivery systems for better therapeutic action without compromising on drug degradation (or) its low bioavailability.
THE INTERACTION OF a-THALASSEMIA WITH SICKLE CELL ANEMIA

The coinheritance of a-thalassemia (a-thal) and sickle cell anemia provides a most interesting example of how separate globin gene mutations influence clinical manifestations of abnormal gene expression. Early reports in the 1 iterature contained conflicting opinions as to whether a-thal ameliorated the clinical consequences of sickle cell disease. With the discovery that the concentration of sickle hemoglobin (Hb S) had a profound influence on both the kinetics (1) and extent (2) of deoxy Hb S polymerization, it was predicted that the lower intraerythrocyti c concentration of Hb S associated with a-thal would mitigate the clinical severity of sickle cell anemia. Moreover, the use of a-globin gene mapping for objectively diagnosing a-thal revealed that one in three Black Americans were silent carriers of a-thal (3). Thus, it followed that a great many sickle cell patients may be affected by this potential 1 y modifying inf 1 uence.
A real-life correlation between clinical SYNTAX score II and carotid intima-media thickness in patients with stable coronary artery disease

Background SYNTAX score II (SSII) is an update of the established SYNTAX score (SS) that uses clinical variables such as age, sex, creatinine clearance, left ventricular ejection fraction, chronic obstructive pulmonary disease, and peripheral arterial disease. Furthermore, SSII has been proven to be a more powerful predictive tool than SS in patients with complex coronary artery disease (CAD). Carotid õntima-media thickness (CIMT) is a widely used noninvasive evidence for subclinical or early atherosclerosis, and it was proved to be an independent predictor for cardiovascular events. Most of the previously published articles studied the association between the CIMT with old cardiovascular scoring systems such as SSI and Gensini score with debatable data about their correlation. Aim To study the correlation between SSII and CIMT in stable CAD patients undergoing elective coronary angiography (CA). Method and patients A prospective study including 155 patients undergoing elective CA for stable CAD excluding patients with history of acute coronary syndrome, previous coronary revascularization either by percutaneous coronary intervention or coronary artery bypass grafting, and previous cerebrovascular stroke. Results The mean age of patients was 58.25 ± 16.46 years, and 79 patients (50.96%) were men. The mean SSII score was 10.23 ± 11.36 and mean CIMT was 0.85 ± 0.24. The correlation between SSII and CIMT using Spearman correlation showed a strong correlation between SSII score and CIMT with correlation coefficient r = 0.752. Conclusion The study showed a strong positive correlation between SSII and CIMT in stable CAD patients undergoing elective CA.
The effectiveness of exercise in the treatment of osteoarthritic knees: a critical review.

Osteoarthritis of the knee is a common cause of pain and disability in the elderly. For many years exercise treatment has been prescribed for patients with knee osteoarthritis. Many authors have investigated the effectiveness of exercise in the treatment of osteoarthritic knees, but due to design flaws in the research undertaken it has been impossible to establish the effectiveness of exercise. Recently, several rigorous studies have been undertaken which have enabled some of the questions regarding the effectiveness of exercise to be answered. A review of the literature has revealed a number of facts regarding exercise treatment for osteoarthritic knees. Exercise treatment when provided by physiotherapists, in a hospital setting, is safe, reduces pain, improves function and increases strength. Exercise classes are well attended and do not exacerbate symptoms in the vast majority of patients. There is no evidence that exercise programmes cause acceleration of the disease process.
The role of GLP-1 receptor agonists as weight loss agents in patients with and without type 2 diabetes

Obesity contributes to the pathogenesis of type 2 diabetes (T2DM) and cardiovascular disease. A modest weight loss of 5–10% can have significant impact on glucose control, medications use and patients’ functionality and quality of life. Until recently, only orlistat was approved in Europe for weight loss. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been shown to improve glycaemia in patients with T2DM with an added benefit of weight reduction. However, the weight loss varies considerably within class and between individuals with up to 30% of patients not losing weight with GLP-1 RA treatment. GLP-1 RAs were placed as a possible second-line treatment as an add on to metformin by the latest ADA/EASD joint guidelines while NICE placed them as third-line agents for patients with T2DM and a body mass index (BMI) ≥35kg/m2 and inadequate glycaemic control. NICE recommended that GLP-1 RAs can be used in patients with BMI <35kg/m2 in ethnic groups, when used as an alternative to insulin where insulin treatment has vocational implications, or if weight loss would be beneficial for other medical reasons. A GLP-1 RA (Saxenda) has recently been approved by the FDA and EMA as a weight loss treatment in patients without T2DM. This paper aims to review the impact of GLP-1 RA treatment on weight loss in patients with and without diabetes, from clinical trials as well as real-life UK data from the ABCD nationwide audits, and also discuss the future role of GLP-1 RAs. Copyright © 2015 John Wiley & Sons. Copyright © 2015 John Wiley & Sons, Ltd.