Miracle-dz/UniFAR-FTUs huggingface dataset:
O Setor Turístico de Hospitalidade: Um Estudo do Perfil do Dirigente de Pousadas e da Satisfação Gerada por Este Tipo de Empreendimento

Este estudo objetivou identificar o perfil dos dirigentes de pousadas da orla aracajuana e sua satisfacao com o empreendimento. O levantamento, realizado no ano de 2001, tem carater exploratoriodescritivo. Foram entrevistados dirigentes de 14 (quatorze) pousadas em um universo de 19 empresas, segundo dados da Empresa Sergipana de Turismo – EMSETUR. Entre as conclusoes da pesquisa estao: o empresario do setor de pousadas da orla de Aracaju e, em sua maioria, do sexo masculino, com idade acima dos 33 anos, tem formacao superior e uma renda mensal acima de R$ 4.000,00 (quatro mil reais); e nascido no Estado de Sergipe e catolico. No tocante a satisfacao com o empreendimento, observaram-se, por diversas vezes, contradicoes nas respostas apresentadas. Os entrevistados ora apontavam como dificuldade enfrentada a falta de comprometimento dos gestores publicos com o turismo, ora apresentavam como oportunidade de crescimento percebida o “bom” trabalho de promocao do turismo feito pelo governo. Palavras-chave: Empresa-diretoria, Hospitalidade, Satisfacao
Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?

BACKGROUND & AIMS Comorbid or extraintestinal symptoms occur frequently with irritable bowel syndrome and account for up to three fourths of excess health care visits. This challenges the assumption that irritable bowel is a distinct disorder. The aims of this study were to (1) assess comorbidity in 3 areas: gastrointestinal disorders, psychiatric disorders, and nongastrointestinal somatic disorders; and (2) evaluate explanatory hypotheses. METHODS The scientific literature since 1966 in all languages cited in Medline was systematically reviewed. RESULTS Comorbidity with other functional gastrointestinal disorders is high and may be caused by shared pathophysiological mechanisms such as visceral hypersensitivity. Psychiatric disorders, especially major depression, anxiety, and somatoform disorders, occur in up to 94%. The nongastrointestinal nonpsychiatric disorders with the best-documented association are fibromyalgia (median of 49% have IBS), chronic fatigue syndrome (51%), temporomandibular joint disorder (64%), and chronic pelvic pain (50%). CONCLUSIONS Multivariate statistical analyses suggest that these are distinct disorders and not manifestations of a common somatization disorder, but their strong comorbidity suggests a common feature important to their expression, which is most likely psychological. Some models explain the comorbidity of irritable bowel with other disorders by suggesting that each disorder is the manifestation of varying combinations of interacting physiological and psychological factors. An alternative hypothesis is that the irritable bowel diagnosis is applied to a heterogeneous group of patients, some of whom have a predominantly psychological etiology, whereas others have a predominantly biological etiology, and that the presence of multiple comorbid disorders is a marker for psychological influences on etiology.
The ClpB ATPase of Streptomyces albus G belongs to the HspR heat shock regulon

The clpB gene of Streptomyces albus was cloned by polymerase chain reaction (PCR) using degenerate oligonucleotides. Transcriptional analysis showed that the clpB gene was heat induced. Primer extension identified a transcription start site preceded by typical vegetative −10 and −35 hexamer sequences. The Streptomyces HspR repressor is known to bind to three inverted repeat motifs (IR1, IR2, IR3) upstream from the S. coelicolor dnaK operon. We identified an inverted repeat motif identical to IR3 upstream from the S. albus clpB gene. DNA‐binding experiments showed that HspR regulates clpB transcription by interacting directly with this motif. Streptomyces albus is the first Gram‐positive organism for which the co‐regulation of DnaK and ClpB has been described. Such co‐regulation suggests that there is a physiological relationship between these two proteins in this bacterium. Genes similar to hspR were also identified in Mycobacterium leprae, M. tuberculosis and in bacteria unrelated to the actinomycetales order, such as Helicobacter pylori and Aquifex aeolicus. HspR binding sites were found in these bacteria upstream from various heat shock genes, suggesting that these genes are regulated by HspR. The HspR binding site, here called HAIR (H spR associated inverted repeat), has the consensus sequence CTTGAGT N7 ACTCAAG.
Application of Structural Events Detected on ASR Outputs for Automated Speaking Assessment

We investigated features reﬂecting utterance structure and disﬂuency proﬁle to improve the automated scoring of spontaneous speech responses by non-native speakers of English. Features derived from structural events (SEs), e.g., clause structure and disﬂuencies, showed promisingly high correlations to the human proﬁciency scores. However, previous studies were based on speech transcriptions, and the usefulness of these SE-derived features on ASR hypotheses was still unknown. In this paper, we reported our studies related to the detection of SEs from noisy ASR outputs and the application of the detected SEs for automated speech scoring. We found that clause boundary (CB) detection was impacted much less than disﬂuency interruption point (IP) detection when facing ASR errors. Next, several features derived from the SEs were evaluated based on their correlations to human scores and their relative importance in a linear regression model.
Promoter Hypermethylation of RASSF 1 A in Esophageal Squamous Cell Carcinoma 1

Purpose: The RAS association domain family 1A (RASSF1A) gene, a candidate tumor suppressor gene, is frequently inactivated by hypermethylation of its promoter region in several human cancers. The aim of this study was to evaluate the promoter methylation status of the RASSF1A in esophageal squamous cell carcinoma. Experimental Design: We analyzed the methylation status of RASSF1A promoter by methylation-specific PCR in 23 esophageal squamous cell carcinoma cell lines and 48 primary tumors. Results: Hypermethylation of RASSF1A was found in 74% of cell lines and 52% of primary tumors. The presence of hypermethylation was statistically associated with loss of RASSF1A mRNA expression in both cell lines (P 0.007) and primary tumors (P 0.003). There was a statistically significant correlation between the presence of hypermethylation and tumor stage (P 0.009). Conclusions: Our findings suggest that epigenetic silencing of RASSF1A gene expression by promoter hypermethylation could play an important role in primary esophageal squamous cell carcinogenesis.
Discovery-based nutritional systems biology: developing N-of-1 nutrigenomic research.

The progress in and success of biomedical research over the past century was built on the foundation outlined in R.A. Fisher's The Design of Experiments (1935), which described the theory and methodological approach to designing research studies. A key tenet of Fisher's treatise, widely adopted by the research community, is randomization, the process of assigning individuals to random groups or treatments. Comparing outcomes or responses between these groups yields “risk factors” called population attributable risks (PAR), which are statistical estimates of the percentage reduction in disease if the risk were avoided or in the case of genetic associations, if the gene variant were not present in the population . High throughput metabolomics, proteomic and genomic technologies provide 21st century data that humans cannot be randomized into groups: individuals are genetically and biochemically distinct. Gene–environment interactions caused by unique dietary and lifestyle factors contribute to heterogeneity in physiologies observed in human studies. The risk factors determined for populations (i.e., PAR) cannot be applied to the individual. Developing individual risk or benefit factors in light of the genetic diversity of human populations, the complexity of foods, culture and lifestyle, and the variety of metabolic processes that lead to health or disease are significant challenges for personalizing dietary advice for healthy or medical treatments for individuals with chronic disease.
Mesophilic Two-Phase Anaerobic Digestion of Excess Sludge Pretreated by Ultrasound and Lime

The effects of combined pretreatment of simultaneous ultrasound (40 KHz, 50 W) and alkaline (lime, dosage of 560 mg/L) were examined on the subsequent mesophilic (35plusmn1degC) two-phase anaerobic digestion. The influent organic loading rate (OLR) of the process was held at about 1.1plusmn0. 2 g VS/L-d, and the total hydraulic retention time (HRT) was 20 days. The results showed that the pretreatment increased the amount of soluble COD, ammonia and total phosphorus of supernatant. The ammonia concentrations in two phases were further enhanced during the anaerobic digestion. However, there was no significant phosphorus release due to the addition of lime. The volatile solids (VS) reduction increased from 29.6% to 40.8% after pretreatment. The specific methanogenic activity (SMA) and specific INT-electron transfer system (ETS) activity were enhanced in two phases. The settlement performance and dewatering ability of sludge became poor after anaerobic digestion.
Complexity of Rhythmic Ability as Measured in Preschool Children

There are many aspects which need to be explored before a comprehensive description of young children's rhythmic ability can be developed. The present study examined the relation of age and sex and preschool children's rhythmic ability expressed in performance with one and two hands, bilateral and parallel use of upper and lower limbs. Two groups of preschool children participated (N = 77), 4.5 to 5.5 and 5.6 to 6.5 yr. of age. A version of the High/Scope Beat Competence Analysis Test was used to assess rhythmic ability. The children performed the same six movements, e.g., parallel movement of hands, bilateral movement of hands, movement of the preferred hand, movement of the nonpreferred hand, bilateral movement of feet in a seated position, and bilateral movement of feet in a standing position. Analysis showed that girls were more accurate than boys on bilateral movement of hands while boys were more accurate than girls on bilateral movement of feet in a seated position. Also, children were more accurate (a) on the movement with the preferred hand than with parallel movement of hands and nonpreferred hand movement, (b) on bilateral movement of hands than with parallel movement of hands and bilateral movement of feet in a seated position, and (c) on bilateral movement of feet while standing than seated. It can be concluded that the various rhythmic movements with upper and/or lower limbs follow different rates of development in preschool children. The above findings may assist physical educators in implementing a physical education program more effectively for the corresponding age groups.
Supportive Care in Pediatric Cancer: The Road to Prevention of Thrombosis

Abstract The survival rate of children with cancer has increased impressively to almost 80% over the last decades as a result of improved diagnostic procedures and multimodal treatment strategies. Therefore, it becomes more and more important to prevent mortality and morbidity of treatment-associated complications, including venous thromboembolism (VTE). VTE occurs predominantly in children with acute lymphoblastic leukemia, lymphoma, and sarcoma. Pathogenesis of thrombosis in children with cancer is multifactorial. Thrombosis develops due to a combination of the primary disease itself, chemotherapy and supportive care, associated complications, and inherited prothrombotic risk factors probably contributed to the development of thrombosis in these children. Mortality as a result of VTE is low, but both symptomatic and asymptomatic thrombosis cause significant morbidity to justify primary thromboprophylaxis in children with cancer. Identification of risk factors is important to develop predictive models to identify patients at highest risk of thrombosis. Due to variations in risk factors, these models should be tailored to treatment protocols and patient populations. Multicenter studies are needed to investigate which prophylactic strategies are effective and safe to prevent thrombosis in children with cancer.
Bisphosphonates and Connexin 43: A Critical Review of Evidence

Abstract Bisphosphonates (BPs) are drugs commonly used in the treatment of various disease arising or affecting bone tissue. There is a standard use in bone neoplasia and metastasis, hormonal and developmental disorders as well as for compensation of adverse effects in several medical therapies. Many in-vivo and in-vitro studies have assessed the efficacy of this drug and its function in cellular scale. In this concern, BPs are described to inhibit the resorptive function of osteoclasts and to prevent apoptosis of osteoblasts and osteocytes. They can preserve the osteocytic network, reduce fracture rate, and increase the bone mineral content, which is therapeutically used. Connexin 43 (Cx43) is a crucial molecule for basal regulation of bone homeostasis, development, and differentiation. It is described for signal transduction in many physiological and pathological stimuli and recently to be involved in BP action.
Performance prediction of large-scale parallell system and application using macro-level simulation

To predict application performance on an HPC system is an important technology for designing the computing system and developing applications. However, accurate prediction is a challenge, particularly, in the case of a future coming system with higher performance. In this paper, we present a new method for predicting application performance on HPC systems. This method combines modeling of sequential performance on a single processor and macro-level simulations of applications for parallel performance on the entire system. In the simulation, the execution flow is traced but kernel computations are omitted for reducing the execution time. Validation on a real terascale system showed that the predicted and measured performance agreed within 10% to 20 %. We employed the method in designing a hypothetical petascale system of 32768 SIMD-extended processor cores. For predicting application performance on the petascale system, the macro-level simulation required several hours.
Comparative evaluation of subclavian vein catheterisation using supraclavicular versus infraclavicular approach

Background and Aims: Infraclavicular (IC) approach of subclavian vein (SCV) catheterisation is widely used as compared to supraclavicular (SC) approach. The aim of the study was to compare the ease of catheterisation of SCV using SC versus IC approach and also record the incidence of complications related to either approach, if any. Methods: In the study, 60 patients enrolled were randomly divided into two groups of 30 patients each. In Gp. SC right SCV catheterisation was performed using SC approach and in Gp. IC catheterisation was performed using IC approach. Access time, success rate of cannulation, number of attempts to cannulate vein, ease of guidewire and catheter insertion and length of catheter inserted and any associated complications were recorded. Results: The mean access time in group SC for SCV catheterisation was 4.30 ± 1.02 min compared to 6.07 ± 2.14 min in group IC. The overall success rate in catheterisation of the right SCV using SC approach (29 out of 30) was better as compared with group IC (27 out of 30) using IC approach. First attempt success in the SC group was 75.6% as compared with 59.25% in the IC group. All successful subclavian vein catheterisations in SC group and IC group were associated with smooth insertion of guidewire following subclavian venipuncture. Conclusion: The SC approach of SCV catheterisation is comparable to IC approach in terms of landmarks accessibility, success rate and rate of complications.
Evidence for Dissociation of Spatial and Nonspatial Auditory Information Processing

Several lines of evidence suggest that visual information processing is segregated into the ventral "what" and dorsal "where" pathways. But the question whether information processing in the auditory system is also parceled to spatial and nonspatial domains remains open. In the present study, we performed simultaneous EEG and MEG recordings during auditory location and pitch delayed matching-to-sample tasks to find out whether working memory processing of the auditory stimulus attribute affects the transient components of the evoked potentials. In both tasks, identical blocks of tone stimuli of one of two frequencies were presented in one of two locations; the only difference between the tasks was the instruction to attend either to the frequency or to the location. In the match condition, the N1 latency was shorter and the N1m amplitude larger in the location task compared to the pitch task. Furthermore, the right-hemisphere generator of N1m elicited in the match condition of the location task was situated significantly medially to the N1m generator in the match condition of the pitch task. Latency and amplitude task-related differences in the N1/N1m components as well as the source location differences indicate at least partial segregation of neuronal mechanisms involved in working memory processing of spatial and nonspatial auditory information.
Lithium, suicide prevention and unipolar depression?

Australia’s suicide rate continues to rise, which is of significant concern, while lithium use has been in decline. The release of the Royal Australian and New Zealand College of Psychiatrists (RANZCP) mood disorder guidelines (Malhi et al., 2015) comprehensively addresses most aspects of mood disorder management, including the important role of lithium. However, the role of lithium’s anti-suicidal effect specifically for unipolar depression is not described. In a recent conceptual overview of suicide in the Lancet (Turecki and Brent, 2016), the role of lithium in reducing suicide was specifically mentioned for both unipolar and bipolar depression. A recent systematic review and meta-analysis of randomized trials (Cipriani et al., 2013) found that in unipolar depression, lithium was associated with a significantly reduced risk of suicide (odds ratio: 0.36, 95% confidence interval [CI] = [0.13, 0.98]). The new metaanalytic findings (Cipriani et al., 2013) in relation to lithium’s specific antisuicidal effects for unipolar depression are an important addition to current clinical knowledge and practice. It is generally known that lithium’s anti-suicidal effect likely relates to more than just its prophylactic benefits for mood disorder relapse. It is thought that lithium may also decrease aggression and impulsivity, which are both mediating factors associated with increased rates of suicide (Cipriani et al., 2013; Turecki and Brent, 2016). The adverse effect profile of lithium is well known including renal insufficiency and thyroid dysfunction (Malhi et al., 2015), which when accompanied by the requirement for regular blood-level monitoring may limit its widespread use by clinicians. The medical risks associated with lithium overdose may also lead to clinical concerns about its safety in potentially suicidal patients. However, from an overall evidence-based perspective, we think lithium should now be considered beyond the acute phase of depression treatment but also as a specific indication for the maintenance treatment of unipolar depressed patients at longitudinal risk of self-harm or suicide (Cipriani et al., 2013). This will require clinician education that lithium may well have effects beyond mood stabilization (Cipriani et al., 2013; Turecki and Brent, 2016), which may include independent anti-suicidal, anti-aggressive, anti-impulsive and possible neuroprotective effects. Further research is required to both confirm the evidence that lithium can prevent suicide in unipolar depression and elucidate its mechanism of action to prevent suicide. This research will help in formulating targeted public health strategies for suicide prevention, as well as providing a better understanding about the neurobiology of suicide.
Implementation of on-chip training system for cellular neural networks using iterative annealing optimisation method

Cellular neural networks proved to be a useful parallel computing system for image processing applications. Cellular neural networks (CNNs) constitute a class of recurrent and locally coupled arrays of identical cells. The connectivity among the cells is determined by a set of parameters called templates. CNN templates are the key parameters to perform a desired task. One of the challenging problems in designing templates is to find the optimal template that functions appropriately for the solution of the intended problem. In this paper, we implement the iterative annealing optimisation method (IAOM) on the analogue CNN chip to find an optimum template by training a randomly selected initial template. We have been able to show that the proposed system is efficient to find the suitable template for some specific image processing applications.
Determinants Of FX-Risk Management Evidence Of Hungary

This paper investigates the motives of FX-risk management based on the changes of forward open positions of Hungarian corporations. We have found that Hungarian companies are significantly more exposed in short EUR forward position, than in EUR long one. Our linear regression model also showed that changing market conditions have an essentially higher impact on the EUR short positions. Our results confirmed that expectations are determining in the risk hedging decisions proving that financial risk management also has a speculative motive.