Miracle-dz/UniFAR-FTUs huggingface dataset:
PENETAPAN RUMUS REGRESI TERHADAP PENENTUAN BOBOT KARKAS BERDASARKAN BOBOT HIDUP SAPI PERSILANGAN SIMMENTAL DI RUMAH PEMOTONGAN HEWAN (RPH) LUBUK BUAYA KOTA PADANG

Penelitian ini bertujuan untuk menetapkan rumus regresi dalam penentuan bobot karkas berdasarkan bobot hidup sapi persilangan Simmental kondisi tubuh sedang umur 1,5-2 tahun. Penelitian ini menggunakan metode survey pada 60 ekor sapi persilangan Simmental, yang dilaksanakan di RPH Lubuk Buaya Kota Padang. Peubah yang diukur adalah bobot hidup, bobot karkas dan persentase karkas. Data hasil pengukuran peubah dianalisis dengan analisis regresi (Steel and Torrie, 1991 dan Santoso dkk, 1992) menggunakan model-model regresi sebagai berikut :1) Ỳ = a + bX (Linear); 2). Ỳ = a.e^bX (Eksponensial); 3). Ỳ = a.X^b (Geometrik); 4). Ỳ = a+b_1X+b_2 X^2 (Kuadratik). Berdasarkan hasil penelitian disimpulkan bahwa bobot hidup dapat dimanfaatkan untuk menduga bobot karkas, dan terdapat hubungan yang erat antara bobot hidup dan bobot karkas pada ternak sapi persilangan Simmental. Model regresi yang paling sesuai untuk menentukan bobot karkas berasarkan bobot hidup adalah model regresi geometrik dengan persamaan Y = 0,4276 . X^(1,002) dan koefisien korelasi, r = 0,8177dan nilai penyimpangan model ( F_(hitung lect of fit)) 0,9835. Bobot hidup ternak sapi persilangan Simmental kondisi tubuh sedang adalah 472,26 kg dan bobot karkas 203,32 kg, dengan persentase karkas 43,06 %. Kata kunci : Sapi persilangan Simmental, bobot karkas, bobot hidup, regresi geometrik.
Curcumin, an active component of turmeric (Curcuma longa), and its effects on health

ABSTRACT Turmeric (Curcuma longa) is a type of herb belonging to ginger family, which is widely grown in southern and south western tropical Asia region. Turmeric, which has an importance place in the cuisines of Iran, Malesia, India, China, Polynesia, and Thailand, is often used as spice and has an effect on the nature, color, and taste of foods. Turmeric is also known to have been used for centuries in India and China for the medical treatments of illnesses such as dermatologic diseases, infection, stress, and depression. Turmeric's effects on health are generally centered upon an orange-yellow colored, lipophilic polyphenol substance called “curcumin,” which is acquired from the rhizomes of the herb. Curcumin is known recently to have antioxidant, anti-inflammatory, anticancer effects and, thanks to these effects, to have an important role in prevention and treatment of various illnesses ranging notably from cancer to autoimmune, neurological, cardiovascular diseases, and diabetic. Furthermore, it is aimed to increase the biological activity and physiological effects of the curcumin on the body by synthesizing curcumin analogues. This article reviews the history, chemical and physical features, analogues, metabolites, mechanisms of its physiological activities, and effects on health of curcumin.
The new way of configuration management of network devices under mutable environment

Network Environment keeps stable usually, but under some extreme cases, the network environment changes regularly. The campus network located at classrooms is a typical case. The right of classroom internet access has been changed according to curriculum schedule. Thus, the network managers have to re-configure the network devices frequently for permitting or forbidding student computers access internet. In this paper, the protocol of telnet was discussed and an idea of network devices automatic configuration based on Telnet, script language and database was prompted. The experiment program of the configuration management of network devices system based on Rujie switches was introduced in detail.
Gonadal Steroid Modulation of Vasopressin Pathways a

Gonadal steroids profoundly influence brain psychology and behavior. During development, these hormones determine whether brains will function in a typical male or female fashion. In adulthood, environmentally induced or endogenously programmed changes in gonadal steroid levels influence steroid-sensitive functions of behaviors. Is2 These actions of gonadal steroids provide valuable tools in relating structure to function, since sexual differentiation of steroid-sensitive functions can be compared with sexual differentiation of structures implicated in these functions. In addition, hormonally induced changes in structure and function can be compared in adult animals. Such comparisons have given insight as to how gonadal steroids mold the brain during development and in adulthood help it generate functions and behaviors relevant to sex and environmental condition. Numerous sex differences have indeed been found, for example, in the size of particular nuclei, the density of synaptic connections, or the extent of dendritic or axonal branching, in areas implicated in steroid-sensitive functions,-’ such as in the medial preoptic area.4 As most of these areas are heterogeneously composed, one would like to identify which particular cellular elements are sexually differentiated. Sorting the various neuronal systems by their neurotransmitter content has proven to be a very fruitful way to unravel various sexually dimorphic structure^. ^ This review will focus on sexually dimorphic vasopressin pathways that provide clear examples of how gonadal steroids may cause sexual differentiation of neural tissue and how these hormones affect neural pathways to influence brain physiology and behavior in adulthood.
Acciones y estrategias de comunicación en plataformas digitales. El caso Cifuentes

Las redes sociales como herramientas de comunicacion politica han tenido un crecimiento permanente durante la ultima decada. La confluencia masiva en estos espacios favorece la imposicion de sentidos por parte de los actores dominantes, mas alla de los tradicionales medios de comunicacion. Este estudio analiza el modo en que fueron utilizadas las plataformas Facebook y Twitter en el marco del denominado Caso Cifuentes. La presidenta de la Comunidad de Madrid resistio en su cargo durante 34 dias luego de que eldiario.es pusiera en duda la veracidad de su Master, supuestamente cursado en la Universidad Rey Juan Carlos. A partir del analisis de contenido de las publicaciones de los actores politicos intervinientes en el caso, se indaga sobre el modo en que condujeron las acciones de comunicacion, asi como las estrategias y soportes utilizados. Desde una perspectiva marcada por la comunicacion politica se exploran los sentidos que cada uno de estos actores pusieron en juego en el marco de estas plataformas. Entre los hallazgos destaca que las redes significaron un espacio mas de disputa desde donde se defendieron ciertos intereses, y como la estrecha relacion con medios tradicionales se mantiene en los espacios digitales.
Perception et action en natation : effets de l’environnement aquatique et de la vitesse de mouvement sur la dynamique des coordinations

L’objectif de ce travail est de caracteriser la dynamique des coordinations de nageurs experts en fonction de la manipulation de contraintes de tâche (vitesse de nage) et d’environnement (ecoulement). Les coordinations intra- et inter-membre (bras vs. bras et bras vs. jambes) sont determinees a l’aide de centrales inertielles positionnees sur des nageurs experts, realisant deux tâches de scanning dans une piscine et un bassin a contre-courant. Nous caracterisons l’effet de l’environnement en comparant la coordination intra-bras a la meme vitesse de nage dans les deux bassins, puis la dynamique de cette meme coordination et de la coordination bras vs. bras lors d’une tâche impliquant huit vitesses. Finalement, la dynamique des coordinations bras vs. jambes est analysee, tout comme l’asymetrie droite/gauche.Nos resultats montrent que le flume canalise l’emergence de comportements fonctionnels, en particulier en faisant decroitre la duree de la phase de glisse du fait de l’ecoulement dynamique de la masse d’eau. L’augmentation de la vitesse de nage montre de plus larges implications des jambes dans la propulsion. La nage dans le flume conduit a une force de couplage plus faible entre les bras et les jambes et de plus larges asymetries droite/gauche. Les nageurs experts sont donc capables d’adapter leurs coordinations intra- et inter-segmentaires et peuvent transiter entre differents patrons en fonction des contraintes auxquelles ils font face. Ainsi, des periodes de stabilite sont couplees avec des periodes de flexibilite comportementales, exemplifiant leur habilete pour realiser le but de la tâche en interagissant fonctionnellement avec l’environnement aquatique.
REGULATION OF VASCULAR TONE BY ENDOTHELIUM‐DERIVED HYPERPOLARIZING FACTOR

1. Endothelium‐derived hyperpolarizing factor (EDHF) mediates the nitric oxide (NO)‐independent component of the relaxation in rat mesenteric arteries. The relationship between hyperpolarization and vascular tone was studied by simultaneous recording of membrane potential with intracellular microelectrodes and tension in ring segments of rat mesenteric arteries.
In vitro generation of a highly immunogenic subline of L1210 leukemia following exposure to 5-(3,3'-dimethyl-1-triazeno)imidazole-4-carboxamide.

Strong and heritable increase of immunogenicity of L1210 Ha leukemia has been obtained in vitro following multiple treatments with 5-(3,3'-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC), metabolically activated by mouse liver preparations (MLP) containing liver microsomes. The DTIC-treated leukemia (L1210D line) or the control line treated with MLP alone (L1210N line) showed comparable growth kinetics in vitro. However, progressive increase of immunogenicity occurred in leukemic cells in the course of in vitro treatments with DTIC plus MIP, but not with MLP alone, as evidenced by comparative studies on transplantation immunity elicited in BALB/c x DBA/2 F1 mice by graded inocula of L1210D or L1210N leukemia cells. In vitro experiments confirmed that metabolic transformation of DTIC is required for increasing tumor immunogenicity. In fact, L1210Ha cells became highly immunogenic when treated with DTIC in intact mice but not in animals metabolically depressed by CCl4. Immunochemotherapy experiments based on the antigenic cross-reactivity between the L1210D line and the original L1210Ha leukemia showed that i.p. administration of L1210D cells followed by 1,3-bis(2-chloroethyl)-1-nitrosourea treatment afforded marked protection in mice inoculated intracerebrally with the parental lymphoma. The present findings could provide an adequate in vitro technique for developing further studies on DTIC-mediated immunogenic changes of tumors, including human cancer cells growing in tissue culture.
Xeya3 regulates survival and proliferation of neural progenitor cells within the anterior neural plate of Xenopus embryos

The transcriptional coactivater and tyrosine phosphatase eyes absent (eya) is vital for eye development in Drosophila. We identified a vertebrate member of the Eya family, Xeya3, which is expressed in the anterior neural plate, including the eye field. Overexpression of wild‐type Xeya3 or of a phosphatase‐negative version of Xeya3 creates massive enlargements of brain and retinal tissues, mainly caused by overproliferation of neural precursor cells. On the other hand, suppression of Xeya3 function induces local apoptosis within the sensorial layer of the anterior neuroectoderm. Thus, Xeya3 is key factor for the formation and size control of brain and eyes in vertebrates. Developmental Dynamics 236:1526–1534, 2007. © 2007 Wiley‐Liss, Inc.
Declining Expression of Neprilysin in Alzheimer Disease Vasculature: Possible Involvement in Cerebral Amyloid Angiopathy

Molecular, genetic, and pharmacological studies have shown that neprilysin (also called NEP) catabolizes amyloid β peptides (Aβ) in healthy conditions. However, in Alzheimer disease (AD), Aβ accumulates forming senile plaques in brain parenchyma and amyloid deposition around blood vessels. In this study, we tested at cellular level the relationship between neprilysin and Aβ in human healthy and AD brain. Our results provided evidence for declining levels of neprilysin in AD brains as compared to healthy controls in parallel with increasing deposition of Aβ. In hippocampus of AD individuals we observed a significant down-regulation of neprilysin expression in pyramidal neurons, consistent with the possibility that neprilysin controls the level of Aβ accumulation and plaque formation in this area. In the cortex and leptomeninges, neprilysin was expressed in the smooth muscle cells of blood vessels. In sections from AD patients we observed a clear inverse relationship between neprilysin and Aβ peptide levels in the vasculature, implicating neprilysin in cerebral amyloid angiopathy.
Common and relative components of reflected light as information about the illumination, colour, and three-dimensional form of objects.

— A model for perceptual analysis of the proximal stimulus into common and residual components, earlier described in a series of papers by Johansson and his co-workers for motion and space perception, is applied to colour perception. Though still premature, this application seems to make colour constancy a natural result of the analysis in the same way as size and form constancy is solved by Johansson's vector analysis in the frame of reference of projective geometry. Applications of the model to Land's Mondrian experiments, to simultaneous contrast, and to the Cornsweet-OBrien effect are outlined. The information from variations and invariances in reflected light (besides the geometrical projection) is discussed with reference to Gibson's ecological optics.
Prácticas organizativas, capacidades dinámicas y desempeño económico

El objetivo principal de esta investigacion versa sobre el analisis de las capacidades dinamicas, sus antecedentes y principales resultados, bajo el prisma del Enfoque Basado en Competencias. Para ello, tras esclarecer la confusion terminologica en la literatura relacionada con los conceptos de recurso, practica, capacidad y competencia, constructos todos ellos clave para la correcta comprension de las capacidades dinamicas, el desarrollo de la presente investigacion se estructura en tres grandes partes. La primera parte se focaliza en el estudio de las relaciones existentes entre las capacidades dinamicas sobre la base de la identificacion de los procesos de gestion del conocimiento que subyacen al desarrollo de cada una de estas capacidades. La delimitacion de las fronteras conceptuales entre las capacidades dinamicas identificadas permite abrir la "caja negra" por la que la empresa acumula, integra y aplica el conocimiento. La segunda parte analiza el efecto de la implementacion de practicas organizativas, en concreto de las practicas de gestion de la calidad y las practicas de organizacion del trabajo, sobre el desarrollo de las capacidades dinamicas. Volviendo a centrar el foco de atencion en las capacidades dinamicas, en un tercer y ultimo bloque se examina el efecto de estas sobre la razon de ser de cualquier empresa: la generacion de rentas economicas. La revision de la literatura en estos tres bloques da lugar al establecimiento de un modelo teorico de relaciones estructurales que es testado en una muestra de 952 empresas industriales espanolas. Los resultados obtenidos permiten comprender mejor el modo en el que la organizacion sirve de marco al desarrollo de las capacidades necesarias para generar rentas economicas superiores.
Influence of magnesium stearate on the physicochemical and pharmacodynamic characteristics of insulin-loaded Eudragit entrapped mucoadhesive microspheres

Abstract Effective oral insulin delivery has remained a challenge to the pharmaceutical industry. This study was designed to evaluate the effect of magnesium stearate on the properties of insulin-loaded Eudragit® RL 100 entrapped mucoadhesive microspheres. Microspheres containing Eudragit® RL 100, insulin, and varying concentrations of magnesium stearate (agglomeration-preventing agent) were prepared by emulsification-coacervation method and characterized with respect to differential scanning calorimetry (DSC), morphology, particle size, loading efficiency, mucoadhesive and micromeritics properties. The in vitro release of insulin from the microspheres was performed in simulated intestinal fluid (SIF, pH 7.2) while the in vivo hypoglycemic effect was investigated by monitoring the plasma glucose level of the alloxan-induced diabetic rats after oral administration. Stable, spherical, brownish, mucoadhesive, discrete and free flowing insulin-loaded microspheres were formed. While the average particle size and mucoadhesiveness of the microspheres increased with an increase in the proportion of magnesium stearate, loading efficiency generally decreased. After 12 h, microspheres prepared with Eudragit® RL 100: magnesium stearate ratios of 15:1, 15:2, 15:3 and 15:4 released 68.20 ± 1.57, 79.40 ± 1.52, 76.60 ± 1.93 and 70.00 ± 1.00 (%) of insulin, respectively. Reduction in the blood glucose level for the subcutaneously (sc) administered insulin was significantly (p ≤ 0.05) higher than for most of the formulations. However, the blood glucose reduction effect produced by the orally administered insulin-loaded microspheres prepared with four parts of magnesium stearate and fifteen parts of Eudragit® RL 100 after 12 h was equal to that produced by subcutaneously administered insulin solution. The results of this study can suggest that this carrier system could be an alternative for the delivery of insulin.
The Efficacy of Guanxinning Injection in Treating Angina Pectoris: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Objective. The randomized controlled trials (RCTs) on Guanxinning injection (GXN) in treating angina pectoris were published only in Chinese and have not been systematically reviewed. This study aims to provide a PRISMA-compliant and internationally accessible systematic review to evaluate the efficacy of GXN in treating angina pectoris. Methods. The RCTs were included according to prespecified eligibility criteria. Meta-analysis was performed to evaluate the symptomatic (SYMPTOMS) and electrocardiographic (ECG) improvements after treatment. Odds ratios (ORs) were used to measure effect sizes. Subgroup analysis, sensitivity analysis, and metaregression were conducted to evaluate the robustness of the results. Results. Sixty-five RCTs published between 2002 and 2012 with 6064 participants were included. Overall ORs comparing GXN with other drugs were 3.32 (95% CI: [2.72, 4.04]) in SYMPTOMS and 2.59 (95% CI: [2.14, 3.15]) in ECG. Subgroup analysis, sensitivity analysis, and metaregression found no statistically significant dependence of overall ORs upon specific study characteristics. Conclusion. This meta-analysis of eligible RCTs provides evidence that GXN is effective in treating angina pectoris. This evidence warrants further RCTs of higher quality, longer follow-up periods, larger sample sizes, and multicentres/multicountries for more extensive subgroup, sensitivity, and metaregression analyses.
Regulation of carbon processes by macrophyte species in a Great Lakes coastal wetland

The objective of this research was to compare and contrast C dynamics within plots occupied by Phragmites australis, Typha spp. , and Sagittaria latifolia in a Lake Erie coastal wetland (Ohio, USA). The effect of each species on above- and belowground biomass, soil C pools, soil labile C, litter decomposition rates, and microbial catabolic response profiles were analyzed. Phragmites australis and Typha spp. produced significantly more aboveground biomass (1,522 ± 464 and 1,177 ± 164 g DM m−2, respectively) than S. latifolia (500 ± 80 g DM m−2), although no difference was observed in terms of belowground biomass. After 208 days in the field, litter of S. latifolia had lost 72% of its initial mass while only 47% of the litter of Typha spp. and P. australis had decomposed. This coupled process of high primary production and slow litter decomposition within P. australis and Typha spp. communities did not translate into greater accumulation of C in the soil. In fact, we observed lower rates of C mineralization and greater biomass of methanogens in the S. latifolia plots. Despite similar water level, soil conditions in the S. latifolia community was more saturated, which might have limited availability of C for microbial consumption in these plots. Microbial catabolic responses to 24 substrates demonstrated distinct differences in the respiration responses of the soil microbial communities of the three macrophyte species. The microbial community found in the rhizosphere of P. australis was particularly responsive to phenolic acids. Few differences in C fluxes and pools were observed between plots occupied by P. australis and Typha spp. , but the replacement of S. latifolia by one of the two other species could have a significant effect on the C cycle in the Great Lakes coastal wetlands.
Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake

The Forkhead transcription factors FoxO1, FoxO3a, and FoxO4 play a prominent role in regulating cell survival and cell cycle. Whereas FOXO1 was shown to mediate insulin sensitivity and adipocyte differentiation, the role of the transcription factor FoxO4 in metabolism remains ill defined. To uncover the effects of FoxO4, we generated a cellular model of stable FoxO4 overexpression and subjected it to microarray-based gene expression profiling. While pathway analysis revealed a disruption of cholesterol biosynthesis gene expression, biochemical studies revealed an inhibition of cholesterol biosynthesis, which was coupled with decreased mRNA levels of lanosterol 14α demethylase (CYP51). FoxO4-mediated repression of CYP51 led to the accumulation of 24,25 dihydrolanosterol (DHL), which independently and unlike lanosterol inhibited cholesterol biosynthesis. Furthermore, FoxO4-overexpressing cells accumulated lipid droplets and triacylglycerols and had an increase in basal glucose uptake. Recapitulation of these effects was obtained following treatment with CYP51 inhibitors, which also induce DHL buildup. Moreover, DHL but not lanosterol strongly stimulated liver X receptor α (LXRα) activity, suggesting that DHL and LXRα mediate the downstream effects initiated by FoxO4. Together, these studies suggest that FoxO4 acts on CYP51 to regulate the late steps of cholesterol biosynthesis.
Construire une marque leader : Comment faire s'épanouir la relation entre une marque et le consommateur ?

Lorsqu'une entreprise perd des parts de marche, c'est souvent parce qu'elle a « oublie » de s'interesser au consommateur. Et donner une orientation marketing a son entreprise pour construire une marque leader, concretement, cela signifie quoi aujourd'hui ? Un demi-siecle apres que les bases du marketing management ont ete formulees au sein de grandes universites americaines et developpees par des leaders mondiaux comme Colgate, Procter & Gamble ou Coca-Cola, quel est le constat ? Les grands principes ont bien ete adoptes et mis en œuvre mais cela s'est souvent accompagne d'une rigidification des processus. Or, cette mecanisation a joue a l'encontre d'une ouverture vers le marche, necessitant souplesse et adaptation a un environnement de plus en plus mouvant. En ce debut de XXIesiecle, marque par le succes de l'Internet et une maturite croissante des marches, le terrain de jeu des marques est bien different de celui des Trente Glorieuses. Alors, comment faire s'epanouir la relation entre une marque et le consommateur ? Comment retrouver le sens du client, vivre l'experience du consommateur a l'ecart des rigidites et dogmes internes ? L'auteur developpe huit themes cles, assortis d'exemples et de cas concrets qu'il a vecus et analyses. Clairs et concrets, ces outils constituent un veritable guide du succes pour la marque et l'entreprise.