Miracle-dz/UniFAR-FTUs huggingface dataset:
Correspondances et transformations actives dédiées aux IHM

La recente evolution vers le Web 2.0 a mis en evidence l'importance de l'interaction entre les utilisateurs et les applications Web. Cependant, cette evolution n'est pas basee sur la transformation de donnees sources en vues cibles (graphiques), malgre l'interet deja demontre d'utiliser les transformations dans un tel contexte. Nous proposons d'utiliser le concept de transformation active en tant qu'objet central des systemes interactifs. Une transformation active transforme des donnees sources en une vue cible mise a jour des lors que les donnees sources changent. Ce papier definit les principes fondamentaux des transformations actives dans une approche IDM. Il explique comment notre environnement AcT permet la generation automatique de transformations actives a partir de correspondances entre meta-modeles source et cible, et comment ces transformations peuvent etre executees sur une plate-forme.
Subclavian flap angioplasty: does the arch look after itself?

OBJECTIVES We sought to assess the early and long-term results of subclavian flap angioplasty in neonates and infants, with particular attention to growth of the hypoplastic arch. METHODS A retrospective analysis of 185 consecutive patients who underwent subclavian flap angioplasty between 1974 and 1998 was carried out. The patients included 125 neonates and 60 infants, with a median age of 18 days. Sixty-six (36%) patients had an additional ventricular septal defect, 41 (22%) patients had aortic arch hypoplasia diagnosed preoperatively, 141 (76%) had an associated patent ductus arteriosus, and 41 (22%) had additional complex heart disease. Follow-up was with transthoracic Doppler echocardiography in all patients. RESULTS The early mortality was 3%. Recoarctation, defined as a Doppler gradient of 25 mm Hg or more, occurred in 11 (6%) patients at a median follow-up of 6.2 years (6.2 +/- 4.6 years). This included 4 of the 41 patients in whom arch hypoplasia was diagnosed preoperatively. There were no complications with the left arm. By multivariate analysis, risk factors for death were determined to be residual arch hypoplasia and low birth weight. The only risk factor for recoarctation was persistent arch hypoplasia after surgical treatment. However, angiographic imaging of the aorta showed that recoarctation was not due to a hypoplastic transverse arch, and it was probably at the site of ductal tissue. Survival at 5 and 10 years was 98% and 96%, respectively. Freedom from reoperation for recoarctation at 2 years was 95%, and at 5, 10, and 15 years, it was 92%. CONCLUSIONS Subclavian flap repair remains an effective technique for repair of aortic coarctation with excellent results and low mortality. In the majority of patients, arch hypoplasia regresses after this procedure.
Determination of External Loop Topology in the Serotonin Transporter by Site-directed Chemical Labeling*

The transmembrane topology of the serotonin transporter (SERT) has been examined by measuring the reactivity of selected lysine and cysteine residues with extracellular reagents. An impermeant biotinylating reagent, sulfosuccinimidyl 2-(biotinamido)ethyl-1,3-dithiopropionate (NHS-SS-biotin), was shown to label SERT transiently expressed in cultured cells. Replacement of four lysine residues that were predicted to lie in external hydrophilic loops (eK-less) largely prevented the biotinylation reaction. Likewise, the cysteine-specific biotinylation reagentN-biotinylaminoethylmethanethiosulfonate (MTSEA-biotin) labeled wild type SERT but not a mutant in which Cys-109, predicted to lie in the first external loop, was replaced with alanine. These two mutant transporters reacted with the biotinylating reagents in digitonin-permeabilized cells, demonstrating that the abundant lysine and cysteine residues predicted to lie in intracellular hydrophilic domains were reactive but not accessible in intact cells. Mutants containing a single external lysine at positions 111, 194, 243, 319, 399, 490, and 571 reacted more readily with NHS-SS-biotin than did the eK-less mutant. Similarly, mutants with a single cysteine at positions 109, 310, 406, 489, and 564 reacted more readily with MTSEA-biotin than did the C109A mutant. All of these mutants were active and therefore likely to be folded correctly. These results support the original transmembrane topology and argue against an alternative topology proposed recently for the related glycine and γ-aminobutyric acid transporters.
College Instructors' Sense of Teaching and Collective Efficacy Helenrose Fives

Helenrose Fives Montclair State University Lisa Looney California State University ` The purpose of this study was to provide an exploratory investigation of college-level instructors’ sense of teaching and collective efficacy. We investigated the relations of teacherand collectiveefficacy with a series of variables: experience, professional level, age, gender, academic domain (for teacher-efficacy only), and academic department (for collective-efficacy only) as well as the relationship between collectiveand teacher-efficacy. Data from 117 graduate students, lecturers, and faculty were analyzed. Differences in teacher-efficacy were found with respect to gender and academic domain. Differences in collective-efficacy were not found across departments, experience levels, or professional levels. Teacher-efficacy was significantly correlated with collective-efficacy.
USING GIS AND REMOTE SENSING TO MAP COASTLINE CHANGES OF WEDAM _ ALSAHEL AREA , BATINAH , OMAN BETWEEN 1998 AND 2008

Abstract: Coastal erosion is a universal phenomenon because of sea level rise, which is considered a result of climate change. This paper aims to detect and measure coastline changes of Wedam_Alsahel area, Batinah, north of Oman using GIS and remote sensing. For this purpose, two satellite images were used. The first one is IRS image acquired in 1998, while the second one is IKONOS image acquired in 2008. The images were geometrically corrected. Spatial resolution of IKONOS image was modified to conform to spatial resolution of IRS image to perform comparison between images. Coastline was identified and digitized in both images, and then coastline changes were measured in many locations along the coast of the area of study. The size of coastline erosion ranged between 50.81 meter and 112.27 meter. The average coastline erosion is 8.78 meter annually. This size of change is very hazardous and it has great impacts on the population and environment. This critical issue needs to be managed. The study introduced some recommendations to deal with this phenomenon.
Physical and Functional Interactions between Escherichia coli MutY Glycosylase and Mismatch Repair Protein MutS

ABSTRACT Escherichia coli MutY and MutS increase replication fidelity by removing adenines that were misincorporated opposite 7,8-dihydro-8-oxo-deoxyguanines (8-oxoG), G, or C. MutY DNA glycosylase removes adenines from these mismatches through a short-patch base excision repair pathway and thus prevents G:C-to-T:A and A:T-to-G:C mutations. MutS binds to the mismatches and initiates the long-patch mismatch repair on daughter DNA strands. We have previously reported that the human MutY homolog (hMYH) physically and functionally interacts with the human MutS homolog, hMutSα (Y. Gu et al., J. Biol. Chem. 277:11135-11142, 2002). Here, we show that a similar relationship between MutY and MutS exists in E. coli. The interaction of MutY and MutS involves the Fe-S domain of MutY and the ATPase domain of MutS. MutS, in eightfold molar excess over MutY, can enhance the binding activity of MutY with an A/8-oxoG mismatch by eightfold. The MutY expression level and activity in mutS mutant strains are sixfold and twofold greater, respectively, than those for the wild-type cells. The frequency of A:T-to-G:C mutations is reduced by two- to threefold in a mutS mutY mutant compared to a mutS mutant. Our results suggest that MutY base excision repair and mismatch repair defend against the mutagenic effect of 8-oxoG lesions in a cooperative manner.
The FACT complex interacts with the E3 ubiquitin ligase Psh1 to prevent ectopic localization of CENP-A

Centromere identity and its epigenetic maintenance require the incorporation of the histone H3 variant CENP-A at centromeres. CENP-A mislocalization may disrupt chromatin-based processes and chromosome segregation. Here, Deyter and Biggins identify a role for the conserved chromatin-modifying complex FACT in preventing CENP-ACse4 mislocalization to euchromatin by mediating its proteolysis. The budding yeast Spt16 subunit of the FACT complex binds to Psh1, an E3 ubiquitin ligase that targets CENP-ACse4 for degradation. A Psh1 mutant that cannot associate with FACT has a reduced interaction with CENP-ACse4 in vivo.
Technical note: Radiofrequency ablation of hepatocellular carcinoma with contrast-enhanced ultrasound guidance: First Indian experience

Abstract Radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) is an established alternative treatment to surgery and intra-arterial chemotherapy, usually performed under contrast-enhanced CT scan guidance. We describe our experience with the use of contrast-enhanced ultrasound and contrast dynamics analysis for planning and monitoring RFA in a patient with HCC.
Semantic Verbs Are Intensional Transitives

In this paper I show that we have strong empirical and theoretical reasons to treat the verbs we use in our semantic theorizing—particularly ‘refers (to)’, ‘applies (to)’, and ‘is true (of )’—as intensional transitive verbs (ITVs). Stating our semantic theories with intensional vocabulary allows us to partially reconcile two competing approaches to the nature and subject-matter of semantics: the Chomskian approach, on which semantics is non-relational, internalistic, and concerns the psychology of language users, and the Lewisian approach, on which semantics is fully relational, specifies truth-conditions, and has metaphysical implications. ITVs have two readings: an intensional, de dicto reading, and a relational, de re reading. A semantic theory stated with the de dicto readings of our semantic verbs captures the core insights of the Chomskian approach to semantics, in part because it allows us to assign extremely fine-grained semantic values to expressions, even when those expressions are empty. On the other hand, the de re reading yields a theory that is fully relational, and issues in truth-conditions. The resulting theories are related— and compatible—in that they are expressed by two different readings of the very same semantic vocabulary, and plausibly, the distinction between these two readings is one of scope.
SigBox: Automatic Signature Generation Method for Fine-grained Traffic Identification

The continual appearance of new applications and their frequent updates emphasize the need for automatic signature generation. Although several automatic methods have been proposed, there are still limitations to their adoption in a real network environment in terms of automation, robustness, and elaboration. To address this issue, we propose an automatic signature generation method, so called SigBox, for fine-grained traffic identification. Using a modified sequence pattern algorithm, this system extracts three types of signatures: content, packet, and flow signature. A flow signature, the final result of this system, consists of a series of packet signatures, and a packet signature consists of a series of content signatures. A content signature is defined as a distinguishable and unique substring of the packet payload. By using the modified sequence pattern algorithm, we can improve the system performance in terms of automation and robustness. In addition, the proposed method can generate an elaborated signature for fine-grained traffic identification by using flow-level features beyond those of the packet level. In order to verify the feasibility of our proposed system, we present the results of experiments based on ten popular applications according to three defined metrics: redundancy, coverage, and accuracy. In addition, we show the quality of the generated signatures as compared to those produced by existing methods.
Aspectos relevantes da lei anticorrupção empresarial brasileira (Lei nº 12.846/2013)

A partir de uma analise critica da Lei no 12.846/2013, que trata da responsabilidade administrativa e civil de pessoas juridicas pela pratica de atos contra a administracao publica, busca-se desenhar um panorama geral do regime juridico relativo a aplicacao das sancoes em face dos atos lesivos as licitacoes, a adocao do compliance pelas empresas, a desconsideracao da personalidade juridica, o acordo de leniencia, a prescricao da punibilidade das infracoes praticadas, e, principalmente, o regime de independencia de instâncias para fins de punibilidade, conforme previsto nos artigos 3o, 18 e 30, o que possibilita a dupla sancao pelo mesmo fato ilicito.
Long-Stem versus Short-Stem Preformed Antibiotic-Loaded Cement Spacers for Two-Stage Revision of Infected Total Hip Arthroplasty

Two-stage revision is the most widely accepted and performed intervention for chronically infected hip prostheses. In recent years short and long stem antibiotic-loaded preformed spacers have become available on the market. The aim of this prospective, comparative study was to assess the safety and efficacy of long stem versus short stem preformed spacers. From year 2000 to 2007 102 consecutive patients underwent two-stage revision of septic hip replacement with a preformed antibiotic-loaded cement spacer and a cementless modular hip revision prosthesis. Patients were divided in two groups: Group L (long stem spacer) (N=60) and Group S (short stem) (N=42) and compared. No systemic toxicity due to local antibiotic release and no spacer breakage were observed in either group. At spacer removal, no statistically significant difference was observed in infection recurrence. After revision, at a mean 4 years follow-up, 2 patients in Group L and 2 in Group S showed infection recurrence. The Harris Hip Score improved in both groups, compared to post spacer implant values: 79.6 ± 15.4 versus 38.4 ± 14.5 in Group L (p < 0.0001) and 82.3 ± 14.4 versus 44.8 ± 16.6 in Group S (p < 0.0001); the difference between groups was not statistically significant. Short and long stem spacers provide comparable low infection recurrence rate and clinical outcome, with negligible risk of breakage and toxicity.
Different Mechanisms Regulate Expression of Zebrafish Myelin Protein Zero (P0) in Myelinating Oligodendrocytes and Its Induction following Axonal Injury*

Background: Zebrafish CNS oligodendrocytes up-regulate axon growth-promoting genes following axonal injury. Results: Separate cis-regulatory elements mediate mpz expression in myelinating oligodendrocytes and its transcriptional induction by axonal damage. Conclusion: Different mechanisms specify oligodendroglial mpz expression in the intact and injured CNS. Significance: Mechanisms underlying the zebrafish repair response might be exploited to enhance axonal regeneration in the mammalian CNS. Zebrafish CNS axons regenerate robustly following injury; it is thought that CNS oligodendrocytes contribute to this response by expressing growth-promoting molecules. We characterized the mpz gene, which encodes myelin protein zero and is up-regulated in oligodendroglia following axonal injury. The 2.5-kb mpz mRNA is expressed from a single TATA box promoter. Four independent Tg(mpz:egfp) transgenic zebrafish lines, in which GFP was expressed under the mpz promoter and 10 kb of genomic 5′-flanking sequence, showed transgene expression in CNS oligodendrocytes from larval development through adulthood. Following optic nerve crush injury, the mpz:egfp transgene was strongly up-regulated in oligodendrocytes along the regenerating retinotectal projection, mirroring up-regulation of endogenous mpz mRNA. GFP-expressing oligodendroglia were significantly more abundant in the regenerating optic pathway, resulting from both transgene induction in oligodendroglial precursors and the birth of new cells. Up-regulation of the mpz:egfp transgene was not dependent on axonal regeneration, suggesting that the primary signal may be axonal loss, debris, or microglial infiltration. Deletion experiments indicated that an oligodendroglial enhancer located in the region from −6 to −10 kb with respect to the mpz transcriptional start site is dissociable from the cis-regulatory element mediating the mpz transcriptional response to axonal injury, which is located between −1 and −4 kb. These data show that different mechanisms regulate expression of zebrafish mpz in myelinating oligodendrocytes and its induction following axonal injury. The underlying molecular events could potentially be exploited to enhance axonal repair following mammalian CNS injury. The transgenic lines and cis-regulatory constructs reported here will facilitate identification of the relevant signaling pathways.
A new potential barrier model in epoxy resin nanodielectrics

The dielectric constant and the conductivity of epoxy resin nanocomposites exhibit a lower value at slight filler loading compared with the host epoxy resin. The electrical strength has an increase and presents an optimal value at filler loading of 1 wt%. The interaction zone between the nanoparticles and the polymeric matrix is considered as an independent region. Accordingly, a new potential barrier model is proposed. Based on the model, carriers are restrained in the interaction zone when nanoparticle is in an isolated dispersion, leading to a decrease in both mobility and density of carriers. As a result, the conductivity decrease and the electrical strength increase. The restriction of dipole movement in the interaction zone and the increase of free volume are collectively contributed to the reduction of the dielectric constant. With increasing filler loading, the thickness of the interaction zone extends due to the overlap of the interaction zone, even a conductive path occurs when filler loading exceeds the percolation threshold, leading to a great increase in both mobility and density of carriers. Consequently, the conductivity increase and the electrical strength decrease. The increase of the dielectric constant is chiefly ascribed to the particles.
Killing of human malaria parasites by macrophage secretory products

The susceptibility of the human malaria parasite, Plasmodium falciparum, to killing in vitro by macrophage secretory products was investigated. The effect of O2 radicals and tumor necrosis factor on parasite viability was assessed both morphologically and by following the uptake of [3H]hypoxanthine. H2O2 produced by the interaction of glucose and glucose oxidase was found to reduce viability; this effect was reversed by the addition of exogenous catalase. Further studies indicated that the catalase level within the erythrocyte was not altered upon parasite invasion. O2 radicals produced during the xanthine-xanthine oxidase interaction also killed P. falciparum. The addition of various O2 radical scavengers (including catalase) did not reverse this effect; therefore, it was not possible to determine which of the O2 radicals were involved in the killing process. Samples from three different sources containing tumor necrosis factor, a nonspecific soluble mediator derived from Mycobacterium bovis BCG-activated macrophages treated with endotoxin, also killed the parasite. There was no evidence that tumor necrosis factor or the products of the xanthine-xanthine oxidase interaction caused damage to the erythrocyte membrane that could be implicated as an important aspect of the killing process. These findings all strongly suggest that such macrophage products play an important role in immunity to malaria.
Distinct sites of origin of oligodendrocytes and somatic motoneurons in the chick spinal cord: oligodendrocytes arise from Nkx2.2-expressing progenitors by a Shh-dependent mechanism.

In the vertebrate spinal cord, oligodendrocytes arise from the ventral part of the neuroepithelium, a region also known to generate somatic motoneurons. The emergence of oligodendrocytes, like that of motoneurons, depends on an inductive signal mediated by Sonic hedgehog. We have defined the precise timing of oligodendrocyte progenitor specification in the cervico-brachial spinal cord of the chick embryo. We show that ventral neuroepithelial explants, isolated at various development stages, are unable to generate oligodendrocytes in culture until E5 but become able to do so in an autonomous way from E5.5. This indicates that the induction of oligodendrocyte precursors is a late event that occurs between E5 and E5.5, precisely at the time when the ventral neuroepithelium stops producing somatic motoneurons. Analysis of the spatial restriction of oligodendrocyte progenitors, evidenced by their expression of O4 or PDGFR(&agr;), indicate that they always lie within the most ventral Nkx2.2-expressing domain of the neuroepithelium, and not in the adjacent domain characterized by Pax6 expression from which somatic motoneurons emerge. We then confirm that Shh is necessary between E5 and E5.5 to specify oligodendrocyte precursors but is no longer required beyond this stage to maintain ongoing oligodendrocyte production. Furthermore, Shh is sufficient to induce oligodendrocyte formation from ventral neuroepithelial explants dissected at E5. Newly induced oligodendrocytes expressed Nkx2.2 but not Pax6, correlating with the in vivo observation. Altogether, our results show that, in the chick spinal cord, oligodendrocytes originate from Nkx2.2-expressing progenitors.
Antennes co-localisées reconfigurables en fréquence pour systèmes MIMO

Ce papier presente trois antennes co-localisees dont les acces presentent un decouplage de l'ordre de 30dB en simulation. La diversite entre chaque antenne est assuree par une combinaison de diversite de polarisation et de rayonnement. Le dispositif a ete dimensionne pour fonctionner autour de 5.25GHz avec une largeur de bande d'environ 9.8%. Toutefois, afin de repondre aux besoins actuels concernant la multiplication de fonctions au sein d'un meme dispositif, une agilite en frequence a ete introduite via l'utilisation de courts-circuits etendant ainsi la bande a 33%, de 5GHz a 7GHz. La faisabilite pratique d'une telle antenne et la fiabilite des choix des differents parametres de simulation ont ete demontres precedemment dans le cas d'une antenne cube du meme type excitee par un seul monopole.
Phenytoin and Carbamazepine: Potential‐ and Frequency‐Dependent Block of Na Currents in Mammalian Myelinated Nerve Fibers

Summary: Voltage clamp experiments were performed in single myelinated nerve fibers of the rat and the effects of phenytoin (PHD and carbamazepine (CBZ) on the ionic membrane currents were studied. PHT and CBZ are almost selective blockers of Na channels. The main part of this inhibition is a potential‐dependent block which can be removed by hyperpolarization. The dose‐response curve of PHT was described as a first‐order reaction with Kd= 37 μM; 100 μM CBZ was equally as effective 100 μM PHT. Both drugs shift the steady‐state Na inactiva‐tion curve (h1(V)) to more negative membrane potentials and decrease its steepness. PHT and CBZ have equimolar effects on the shift and decrease in steepness of h1(V). All of the drug‐induced effects depend on drug concentration. Both drugs induce a slowing of recovery from Na inactivation. PHT has a stronger slowing effect than CBZ. From this ensues a frequency‐dependent block, which is more pronounced in the presence of PHT than of CBZ. The effects of both drugs can be interpreted in the framework of the modulated receptor hypothesis.