Miracle-dz/UniFAR-FTUs huggingface dataset:
Implementation challenges in worksite health promotion programs.

challenges that occur during planning, development, implementation, and evaluation efforts. In this commentary, we focus on implementation challenges faced by employers— issues that must be addressed after an organization has made a commitment to offering a worksite health promotion program. Of course, initial support from top management must be secured. But evidence suggests that management support alone does not guarantee program success. A nationally representative sample of employers responded to the 2004 National Worksite Health Promotion Survey and reported that the most common barriers or challenges to health promotion program success were: lack of interest among employees (63.5%); lack of staff resources (50.1%); lack of funding (48.2%); lack of participation among high-risk employees (48.0%); and lack of management support (37.0%). No significant differences in barriers were reported based on industry type or worksite size except that worksites with 750+ employees were significantly more likely to report lack of participation by high risk employees as a barrier. We review each of these potential implementation challenges and argue that engaging employees and managers in identifying and addressing them early in the planning process allows an organization to develop the necessary strategies to overcome them. First, some employers clearly believe that employees are not interested in worksite health promotion programs. This tends to occur when employee participation in programs is low. It is important to both understand and clarify some of the potential underlying “causes” of low levels of employee interest and participation. For example, insufficient or ineffective communication about health promotion programs could result in low levels of participation simply because employees were not aware of programs being offered. Another potential “cause” of low perceived employee interest is that employees might not participate at all (or in lower numbers) if they have to pay to join a program, or if the program is offered at inconvenient times or locations, or when child care and other issues may limit participation. Employees exposed to stressful and/or otherwise hazardous work conditions might not participate because they are skeptical of worksite health promotion programs and/or angry if these programs are being prioritized ahead of addressing work conditions. Additionally, if employees believe that employers are intruding on their privacy or trying to “control” their health, they may not participate. Thus, low employee participation may be caused by several of these factors and may lead to a perception among employers that employees are not “interested” in health promotion programs. Implementation Challenges in Worksite Health Promotion Programs
Human herpesvirus type 8 and Epstein–Barr virus‐associated cutaneous lymphoma taking anaplastic large cell morphology in a man with HIV infection

Human herpesvirus type 8 (HHV‐8, Kaposi's sarcoma‐associated herpesvirus)‐positive lymphoma taking anaplastic large cell morphology in the skin is described in a 46‐year‐old man with AIDS. Multiple erythematous nodules appeared on the trunk and extremities during the treatment of AIDS. Histological examination of cutaneous nodules showed dense infiltration of CD30 + atypical lymphoid cells in the deep dermis. Immunoglobulin JH gene rearrangement was detected in these lymphoma cells. Both Epstein–Barr virus‐encoded small RNA and HHV‐8 mRNA (T1.1/nut‐1) were detected in these lymphoma cells by in situ hybridization. Remarkable retention of the pericardial fluid was observed at the same time that cutaneous lesions grew, and lymphoma cells in the pericardial fluid showed the same phenotype as the cutaneous lymphoma. Chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone effectively reduced both the cutaneous nodules and pericardial fluid. However, the patient died 4 months after diagnosis because of cytomegalovirus infection. As far as we know, this is the first report of an HHV‐8‐positive cutaneous lymphoma taking anaplastic large cell morphology. This case suggests the association of AIDS‐related anaplastic large cell lymphoma with HHV‐8.
Amniotic Fluid Lecithin/Sphingomyelin Ratio as an Index of Fetal Maturity

A simple, rapid and reproducible semiquantitative method for determining the amniotic fluid phospholipid lecithin/sphingomyelin (L/S) ratio was used to study 190 samples from 140 women. L/S ratio and infant birth-weight correlated significantly (r = 0.5). Amniotic fluid L/S ratio correlated significantly with amniotic fluid fat cells (Nile blue stain), bilirubin (ΔLOD400), creatinine and amniotic fluid/maternal blood creatinine ratio. In small infants (<2500 g) with an L/S ratio >2.0, neonatal respiratory problems were not noted. In infants with an L/S ratio <2.0, 6 (33.3%) had respiratory distress and 3 (16.7%) died of respiratory problems. This test is recommended before early delivery to decrease neonatal respiratory problems.
Activation of major vault protein by TGF-beta is associated with advanced malignancy and poor prognosis in breast cancer

Emerging studies have demonstrated that major vault protein (MVP) may play critical roles in tumor development and progression. However, the biology functions of MVP in breast cancer have not yet been evaluated. The present study is to investigate the expression level and the significance of MVP in breast cancer and to explore the mechanism underlying the deregulation of MVP. We examined the expression of MVP and the relationship with clinicopathological features. Cell proliferation and transwell assays were performed to explore the effect of MVP in breast cancer cell lines. The results indicated that the expression levels of MVP mRNA and protein were significantly higher in breast cancer tissues and the overexpression of MVP was associated with lymph node invasion and advanced tumor stage. We also identified that MVP could be an independent prognostic factor. In addition, knockdown of MVP showed that deficiency of MVP retarded cell growth and invasion ability. Furthermore, we noticed that TGF-β signaling activation was involved in regulating MVP expression as MVP expression could be reduced by TGF-β signaling inhibitor. In conclusion, we found that abnormal activation of TGF-β signaling could induce MVP expression and high expression level of MVP promoted breast cancer cells proliferation and invasion, indicating that MVP could serve as a potential target for therapy of breast cancer.
Standardize Concepts, Not Tools for Quality Improvement

Pay for performance has become a new mantra in the ongoing efforts to improve the quality of healthcare and stabilize healthcare costs. In response to complaints of employers and others, numerous organizations have emerged to try and standardize the tools used to measure quality. This article maintains that such an approach will not lead to improvement in quality. Rather, we should be standardizing on specific quality of care concepts, such as hospital satisfaction or bypass graft mortality. In turn, appropriate federal agencies should calibrate (or translate) well-validated tools measuring desired concepts. This would allow consumers to take action on quality reports calibrated to allow comparison of results based on a standardized concept such as hospital satisfaction but which in turn contains results using different, well-validated satisfaction questionnaires. This article provides a road map for the implementation of a process of standardizing on concepts rather than tools.
Group B vaccine development : present status Streptococcus and future considerations , with emphasis on perspectives for low and middle income countries

Globally, group B (GBS) remains the leading cause of sepsis Streptococcus and meningitis in young infants, with its greatest burden in the first 90 days of life. Intrapartum antibiotic prophylaxis (IAP) for women at risk of transmitting GBS to their newborns has been effective in reducing, but not eliminating, the young infant GBS disease burden in many high income countries. However, identification of women at risk and administration of IAP is very difficult in many low and middle income country (LMIC) settings, and is not possible for home deliveries. Immunization of pregnant women with a GBS vaccine represents an alternate pathway to protecting newborns from GBS disease, through the transplacental antibody transfer to the fetus in utero. This approach to prevent GBS disease in young infants is currently under development, and is approaching late stage clinical evaluation. This manuscript includes a review of the natural history of the disease, global disease burden estimates, diagnosis and existing control options in different settings, the biological rationale for a vaccine including previous supportive studies, analysis of current candidates in development, possible correlates of protection and current status of immunogenicity assays. Future potential vaccine development pathways to licensure and use in LMICs, trial design and implementation options are discussed, with the objective to provide a basis for reflection, rather than recommendations. 1,2 3 4-6 7
Use of the Student-Tat to Assess Coping Behavior in Hospitalized, Normal, and Exceptionally Competent College Freshmen

The college freshman year, as a transition period in late adolescent development, is assumed to provide new and stressful situations that challenge the adaptive and problem-solving potential of entering freshmen. All transitions are periods of vulnerability, but they are also, in normal development, stimuli for the rehearsal of coping responses to problem tasks in novel simations. W e were interested in devising an economical and reliable psychological instrument for measuring the coping behavior potential of adolescents during their college freshman year. In a report of a pilot study of competent adolescents in transition from high school to college, we defined coping behavior, from a personality-social viewpoint, as having two broad components: " (a) the effectiveness with which each task is accomplished and ( b ) the cost to the individual of this effectiveness. Behavior may be considered to serve coping functions when it increases the likelihood . that a task will be accomplished according to standards that are tolerable both to the individual and to the group in which he lives" (Silber, Hamburg, Coelho, Murphey, Rosenberg, & Pearlin, 1961 ) . A TAT-type projective test was designed for making pre-diagnostic assessments of the coping behavior potential of college freshmen. Our research aim was twofold: ( a ) to develop a method for analyzing story productions elicited in response to various problem college situations, and ( b ) to determine how three groups of freshmen who were known to differ independently in their behavioral competence differed in fantasied coping responses to specific problem tasks in adolescent development. W e hypothesized that normal and clinically disrurbed groups of freshman Ss would differ in problem-solving competence when dealing with adaptive
Retriever wire supported carotid artery revascularization (ReWiSed CARe) in acute ischemic stroke with underlying tandem occlusion caused by an internal carotid artery dissection: Technical note

We hereby report a novel technical approach for the treatment of acute stroke with underlying tandem occlusion. The so-called retriever wire supported carotid artery revascularization (ReWiSed CARe) technique, utilizing the wire of a stent-retriever as a guiding wire for carotid artery stenting, is technically feasible in tandem occlusions caused by an internal carotid artery (ICA) dissection or high grade ICA stenosis. This technique eliminates the need to use a long microwire in order to maintain the position inside the true lumen of a dissection. Additionally, it leads to anterograde perfusion through the released stent-retriever during the time of ICA stenting, which is favorable in all tandem occlusion cases.
On the inter-relations between artificial and physiological neural networks

Abstract This paper discusses the inter-relations between findings on the physiological neural network (PNN) and artificial neural networks (ANN). It discusses the interaction of progress in both PNN and ANN for the purpose of borrowing from ANN's mathematical understandings to establish pointers for further explorations to better understand the PNN, and also for the reciprocal transferring of knowledge from PNN findings to improve ANN schemes. Such improvements in ANN are essential for better handling the needs of the information technology (IT) explosion in dealing with huge data bases and where data often defy analysis and are incomplete and fuzzy. On the other hand, principles and elements of ANN designs that appear to be important and successful can serve as guides for identifying them in the PNN, to be subsequently confirmed by bioanalytical tests. Hence progress in PNN is obviously essential for progress in ANN, as is progress in ANN helpful in PNN modeling, though its laboratory confirmation is still a far lengthier process. We discuss certain specific ANN schemes with respect to the above inter-relations with PNN. We feel that the progress in both PNN and ANN research provides a major link between the thrust in information technology developments and the thrust in biological science research, which are most probably the two major focus areas of research at the dawn of the 21st century. [Neurol Res 2001; 23: 482-488]
Compartmentalization of Pancreatic Secretory Zymogen Granules as Revealed by Low-Voltage Transmission Electron Microscopy

Low-voltage (5-kV) transmission electron microscopy revealed a novel aspect of the pancreatic acinar cell secretory granules not previously detected by conventional (80-kV) transmission electron microscopy. Examination of ultra-thin (30-nm) sections of non-osmicated, stain-free pancreatic tissue sections by low-voltage electron microscopy revealed the existence of granules with non-homogeneous matrix and sub-compartments having circular or oval profiles of different electron densities and sizes. Such partition is completely masked when observing tissues after postfixation with osmium tetroxide by low-voltage transmission electron microscopy at 5 kV and/or when thicker sections (70 nm) are examined at 80 kV. This morphological partition reflects an internal compartmentalization of the granule content that was previously predicted by morphological, physiological, and biochemical means. It corresponds to the segregation of the different secretory proteins inside the granule as demonstrated by high-resolution immunocytochemistry and reflects a well-organized aggregation of the secretory proteins at the time of granule formation in the trans-Golgi. Such partition of the granule matrix undergoes changes under experimental conditions known to alter the secretory process such as stimulation of secretion or diabetes.
Colorectal Cancer Screening Among Latinos in Three Communities on the Texas–Mexico Border

Objective. To assess colorectal cancer screening (CRCS) prevalence and psychosocial correlates of CRCS among Latinos in South Texas. Method. Using multivariable analyses, we examined the association of perceived susceptibility, self-efficacy, pros and cons, subjective norms, knowledge and fatalism on CRCS among 544 Latinos (50 years and older). Results. In this socioeconomically disadvantaged population, 40% had never heard of any CRCS test, only 34% reported ever completing any type of CRCS, and only 25% were adherent to CRCS guidelines. Insurance status, gender, perceived cons, CRCS self-efficacy, and CRCS norms were significantly associated with CRCS. Conclusion. CRCS interventions in this population should focus on improving access, increasing self-efficacy and perceived norms, and decreasing negative perceptions of CRCS.
Converters with AC transformer intermediate link suitable as interfaces for supercapacitor energy storage

The paper considers a problem of construction, control and design of converters designed as interfaces between supercapacitor energy storage battery with maximal voltage not higher than 100 V and DC link with voltages corresponding to standard grid voltage (over 600 V). The main feature of this type of converters is the presence of an intermediate AC medium frequency link with transformer permitting the direct voltage fitting. Two types of the converter are investigated showing advantages and disadvantages of both solutions. As more promising the solution with voltage type intermediate DC link on low voltage side has been analyzed and tested in details. The matching of DC capacitance with AC- stray inductance together with proper phase synchronization of DC power controlling converter with AC link voltage permit to obtain a better power factor of DC/AC/DC converters and lower capacitor current, which improved efficiency ensuring the good dynamic. The investigation of the converter circuit and its control is done with the use of exact simulation model and verified on laboratory bench with MOS and IGBT converters and ferrite core transformer.
Closure of the spheno‐occipital synchondrosis

Comparative anatomical and histologic methods have been responsible for the belief that the spheno‐occipital synchondrosis in the human is an active growth center until the adult stage is reached. According to standard texts the suture closes between the eighteenth and twenty‐fifth years. The present investigation was a re‐examination of this question by means of midsagittal laminagraphy. The material consisted of 205 males 8 to 21 years; and 193 females 6 to 18 years. The midsagittal lamina of the spheno‐occipital junction appears as a band of less radiopacity when the suture is open. Closure was found to occur first on the cranial border and to progress downward. Initial closure was found in a male of 10 years, 10 months; first complete closure at 13 years, 4 months. The last found completely open was at 15 years, 2 months. Complete obliteration was found at 8 years, 1 month in one female subject and the last completely open suture at 13 years, 9 months. In general, the closing age for the males was between 13–16 years, and the female between 11–14 years.
The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo.

Insulin-like peptide 5 (INSL5), a member of the insulin/relaxin superfamily, can activate the G-protein-coupled receptor relaxin/insulin-like family peptide receptor 4 (RXFP4), but its precise biological functions are largely unknown. Recent studies suggest that INSL5/RXFP4 is involved in the control of food intake and glucose homoeostasis. We report in the present study that RXFP4 is present in the mouse insulinoma cell line MIN6 and INSL5 augments glucose-stimulated insulin secretion (GSIS) both in vitro and in vivo. RXFP4 is also expressed in the mouse intestinal L-cell line GLUTag and INSL5 is capable of potentiating glucose-dependent glucagon-like peptide-1 (GLP-1) secretion in GLUTag cells. We propose that the insulinotrophic effect of INSL5 is probably mediated through stimulation of insulin/GLP-1 secretion and the INSL5/RXFP4 system may be a potential therapeutic target for Type 2 diabetes.
Fluoroquinolones and risk of Achilles tendon disorders: case-control study

Fluoroquinolones have been associated with tendon disorders, usually during the first month of treatment,1–5 but the epidemiological evidence is scanty. We did a nested case-control study among users of fluoroquinolones in a large UK general practice database to study the association with Achilles tendon disorders. We obtained data from the IMS Health database (UK MediPlus), which contains data from general practice on consultations, morbidity, prescriptions, and other interventions in a source population of 1-2 million inhabitants. The base cohort consisted of all patients aged 18 years or over who had received a fluoroquinolone. We excluded people with a history of Achilles tendon disorders, cancer, AIDS, illicit drug use, or alcohol misuse. We identified potential cases by reviewing patient profiles and clinical data and excluded tendon disorders due to direct trauma. We randomly sampled a group of 10 000 control patients from the study cohort. We defined four categories of exposure to …
Evolutionary design of decision trees

Decision tree (DT) is one of the most popular symbolic machine learning approaches to classification with a wide range of applications. Decision trees are especially attractive in data mining. It has an intuitive representation and is, therefore, easy to understand and interpret, also by nontechnical experts. The most important and critical aspect of DTs is the process of their construction. Several induction algorithms exist that use the recursive top‐down principle to divide training objects into subgroups based on different statistical measures in order to achieve homogeneous subgroups. Although being robust and fast, generally providing good results, their deterministic and heuristic nature can lead to suboptimal solutions. Therefore, alternative approaches have developed which try to overcome the drawbacks of classical induction. One of the most viable approaches seems to be the use of evolutionary algorithms, which can produce better DTs as they are searching for globally optimal solutions, evaluating potential solutions with regard to different criteria. We review the process of evolutionary design of DTs, providing the description of the most common approaches as well as referring to recognized specializations. The overall process is first explained and later demonstrated in a step‐by‐step case study using a dataset from the University of California, Irvine (UCI) machine learning repository. © 2012 Wiley Periodicals, Inc.
Tissue Engineering in the Trachea

This review summarizes efforts to generate an autologous tissue‐engineered trachea (TET) using various biomaterial or cell sources to make tracheal cartilage to form the structural components of a functional tracheal replacement. Biomechanical assessments of the TET showed that the cartilage stiffness was excellent in the nude models; however, the sheep autologous TET did not provide sufficient support and collapsed easily. As a result, tissue engineering technology is still far from allowing the functional recovery of patients who suffer from severe tracheal disease. On the other hand, there are several clinical reports seeding cells to decellularized tissue using tissue engineering techniques. However, the working mechanisms of the tissue‐engineered trachea remain unclear. Nevertheless, we believe that the field of tissue engineering has great potential for surmounting these obstacles and allowing us to generate functional tracheal replacements in the near future. Anat Rec, 297:44–50. 2014. © 2013 Wiley Periodicals, Inc.
Beneficial effects of rituximab on primary cold agglutinin disease refractory to conventional therapy

Abstract: A case is reported of lymphoplasmacytoid lymphoma (LPL) associated with a monoclonal immunoglobulin (Ig) M and cold agglutinin disease (CAD) that was successfully treated with rituximab. A 52‐yr‐old male was admitted with a direct antiglobulin test positive haemolytic anaemia and thrombocytopenia associated with monoclonal IgM. Bone marrow examinations disclosed the marked infiltration of medium‐sized lymphoma cells with plasmacytoid differentiation that indicated non‐Hodgkin's lymphoma of B‐cell origin (LPL). Prednisolone and combination chemotherapy were temporarily effective for both anaemia and thrombocytopenia, although these strategies became refractory and bone marrow lymphoplasmacytosis persisted. CAD ameliorated, and the serum level of IgM decreased in association with the disappearance of lymphoma cells and clonal rearrangement of the Ig heavy chains in the bone marrow after treatment with rituximab. Rituximab played a significant role in the treatment of refractory CAD associated with LPL.