Miracle-dz/UniFAR-FTUs huggingface dataset:
Myocardial Infarction Response to Prasugrel and Levels of Circulating Reticulated Platelets in Patients With ST-Segment Elevation Myocardial Infarction

ardiology Department, R Faculty of Medicine, T epartment, School of Ph srael; zDepartment of M l School, Boston, Massach abin Medical Center, P the Grant for Young Inv s have reported that they disclose. pt received May 1, 201 y 31, 2013. he aim of this study was to determine whether response to prasugrel is associated with the proportion of circulating reticulated platelets (RPs) in patients with ST-segment elevation myocardial infarction (STEMI).
Self-Application of Complementary and Alternative Medicine by Patients with Gynecologic Cancer

Objectives: In this study we aimed to determine the epidemiology and demographic data on complementary and alternative medicine (CAM) use along with the medical/surgical treatment modalities in patients with gynecologic cancers in Turkey. Materials and Methods: A cross-sectional study was designed to determine demographic data on CAM use of patients with gynecologic cancers who had medical and/or surgical treatments. Semistructured questionnaires were used for collecting data from 126 patients. Results: When the CAM use ratio of patients was evaluated with respect to demographic characteristics, patients using any type of CAM were younger and more educated, and there were no significant differences between the patients who used and who did not use any type of CAM with respect to geographical region. There were no significant correlations between the use of CAM and the type of malignancy, treatment modality and time period after diagnosis. Conclusion: There is critical concern about the probable serious risks associated with non-educated CAM practitioners. Therefore, informed and educated healthcare professionals should inform and help in relieving patients in a more professional and multidisciplinary way.
Transmission success of the malaria parasite Plasmodium mexicanum into its vector: role of gametocyte density and sex ratio

The life-cycle of Plasmodium depends on transmission of the parasite from the vertebrate host into its vector when the insect takes a bloodmeal. Transmission success may depend in part on the parasite's gametocyte density and sex ratio in the blood. P. mexicanum, a parasite of fence lizards in California, USA, exploits the sandfly Lutzomyia vexator as its vector. In experimental transmissions using naturally infected lizards as donors of blood, transmission success (measured as percentage of vectors infected and number of parasite oocysts on the insect's midgut) was positively related to gametocyte density, although density above 20/1000 erythrocytes did not improve transmission. Sex ratio (proportion of microgametocytes in the infection) was positively correlated with gametocyte density. Transmission improved with higher proportion of microgametocytes, but partial correlations revealed that this was a result only of higher gametocyte densities. These results agree with the theory of virulence and sex ratios because single clone infections should produce a more female-biased sex ratio and grow to the minimum parasitaemia that would maximize clonal transmission, whereas multiple clone infections will be closer to a 1[ratio ]1 sex ratio and yield a higher parasitaemia when each clone competes for transmission to the vector.
A Family Study in Oman: Large, Consanguineous, Polygamous Omani Arab Pedigrees

Objective: To establish a suitable human model for the study of the genetics of complex diseases. Methods: We have selected an Omani Arab population to provide the statistical power required to study the genetics of complex diseases with confidence. This model consists of five multigenerational highly inbred pedigrees, descending from a small number of founders just a few generations ago with environmental homogeneity, restricted geographical distribution, detailed records and well-ascertained and -validated pedigrees. Stringent criteria were adopted for defining the phenotypes of hypertension, diabetes mellitus, dyslipidemias and obesity. The SOLAR genetic software package was used to draw the pedigree structure. Results: Outstanding statistical power to detect susceptibility loci was obtained. Conclusions: This model represents a large homogeneous human family-based population for the study of genetic and environmental factors contributing to complex diseases.
Performance Comparison of Enterprise Applications on Mobile Operating Systems

Seiring kemajuan dalam teknologi ponsel, Smartphone memiliki kemampuan untuk mengakses layanan web dalam aplikasi pengguna berinteraksi untuk mengambil dan mengirim informasi dari dan ke layanan web. Karenanya, Smartphone semakin meningkat popularitasnya. Pemanfaatan layanan web baru dan layanan web yang telah ada juga akan tumbuh pesat. Makalah ini memberikan perbandingan dari dua jenis utama dari layanan web: SOAP dan REST. Kinerja penggunaaan SOAP dan REST pada smartphone juga dievaluasi. Pengujian yang dilakukan meliputi waktu yang dibutuhkan untuk melakukan panggilan layanan web, RAM digunakan membuat panggilan layanan web, dan data yang dikirim dan diterima ketika membuat panggilan layanan web.
Technical Efficiency, Environment Efficiency, Productivity and Beneficial Management Practices

An input distance function (IDF) is estimated to empirically evaluate and analyze the technical and environmental efficiencies of 210 farms located in the Chaudiere watershed (Quebec), where water quality problems are particularly acute because of the production of undesirable outputs that are jointly produced with agricultural products. The true IDF is approximated by a flexible translog functional form estimated using a full information maximum likelihood method. Technical and environmental efficiencies are disaggregated across farms and account for spatial variations. Our results show that there is a significant correlation between technical and environmental efficiencies. Farms that are technically efficient tend to be environmentally efficient. We used the cumulative Malmquist productivity index and the Fisher index to measure changes in technology, profitability, efficiency, and productivity in response to the adoption of 2 selected best management practices (BMPs) whose objective is to reduce water pollution. We found significant differences across BMPs regarding the direction and the magnitude of their effect on profitability, efficiency and productivity.
Electronic Prescription Writing Errors in the Pediatric Emergency Department

M edication errors in the pediatric setting are common. The error rates range from 4% to 30% of all medication orders. These errors include the wrong dose, route, frequency, and medication choice, and can lead to an adverse drug event (ADE) in up to 16% of pediatric patients. The ADEs can require emergency medical care and hospital admission. The Food andDrugAdministration reported that ADEs (injuries, disabilities, and death) tripled between 1998 and 2005. Medication errors occur in the emergency department as well. In 1 study at a pediatric tertiary care hospital, medication errors occurred in 10% of orders placed in the emergency department. Medication errors among ambulatory prescriptions written in the pediatric emergency department (PED) are also common, ranging from 4.3% to 59%. In these studies, the majority of errors are due to incorrectly writing the prescription, including minor omissions or incomplete directions, and not due to incorrect dosing. Physicians with numerous different training backgrounds, many of which are not primarily pediatric-based, work in academic PEDs. Some studies show that trainees have a higher error rate than attendings and that level of training is directly related to error rate. In terms of resident specialty, research shows that emergency medicine residents need further training in pediatric medication dosing. The electronic health record (EHR) and computerized physician order entry (CPOE) have the potential to improve prescription error rates. The EHR and CPOE software helps to prevent medication errors by connecting to either an online formulary, which provides recommended dosing and lists the side effects of a medication, or with a formal clinical decision support system (CDSS). The CDSS links the formulary to the patient's chart and will provide alerts, for example, if drug dose is in excess for age or weight or if there is an allergy contraindication to a medication. The Institute of Medicine recently endorsed CPOE software as a necessity to reduce medication error rates. A recent review found that the introduction of CPOE in the emergency department decreased medication error rates. More specifically, a second study found that electronic prescribing systems reduced error in a PED. The role of specialty and level of training on electronic prescription errors, however, has yet to be addressed in the literature. The purpose of this study is to evaluate the frequency, type, and severity of electronic prescription errors written by residents in
Learning‐induced modulation of SK channels‐mediated effect on synaptic transmission

Although small conductance (SK)‐mediated calcium‐dependent potassium currents are usually mostly thought to modulate neuronal adaptation by suppressing repetitive spike firing, recent evidence suggests that these channels also modulate synaptic transmission. SK2 channels were shown to be activated in dendritic spines following calcium entry via N‐methyl‐d‐aspartate (NMDA) receptor. Such activation of potassium currents terminates the NMDA‐dependent postsynaptic potential (PSP).
The place of eprints in scholarly information delivery

The continuing high costs of scholarly information provision have encouraged the proliferation of eprint servers. We have seen the establishment of the Chemistry Preprint Server, PhilSci Archive and ClinMed, to mention just three examples. Both the well‐established and the evolving eprint repositories offer hope that academic libraries can continue to provide access to required scholarly information at reasonable cost. The paper describes the advantages of eprint servers and possible obstacles to their acceptance.
Direct Metabolic Interrogation of Dihydrotestosterone Biosynthesis from Adrenal Precursors in Primary Prostatectomy Tissues

Purpose: A major mechanism of castration-resistant prostate cancer (CRPC) involves intratumoral biosynthesis of dihydrotestosterone (DHT) from adrenal precursors. We have previously shown that adrenal-derived androstenedione (AD) is the preferred substrate over testosterone (T) for 5α-reductase expressed in metastatic CRPC, bypassing T as an obligate precursor to DHT. However, the metabolic pathway of adrenal-derived DHT biosynthesis has not been rigorously investigated in the setting of primary disease in the prostate. Experimental Design: Seventeen patients with clinically localized prostate cancer were consented for fresh tissues after radical prostatectomy. Prostate tissues were cultured ex vivo in media spiked with an equimolar mixture of AD and T, and stable isotopic tracing was employed to simultaneously follow the enzymatic conversion of both precursor steroids into nascent metabolites, detected by liquid chromatography-tandem mass spectrometry. CRPC cell line models and xenograft tissues were similarly assayed for comparative analysis. A tritium-labeled steroid radiotracing approach was used to validate our findings. Results: Prostatectomy tissues readily 5α-reduced both T and AD. Furthermore, 5α-reduction of AD was the major directionality of metabolic flux to DHT. However, AD and T were comparably metabolized by 5α-reductase in primary prostate tissues, contrasting the preference exhibited by CRPC in which AD was favored over T. 5α-reductase inhibitors effectively blocked the conversion of AD to DHT. Conclusions: Both AD and T are substrates of 5α-reductase in prostatectomy tissues, resulting in two distinctly nonredundant metabolic pathways to DHT. Furthermore, the transition to CRPC may coincide with a metabolic switch toward AD as the favored substrate. Clin Cancer Res; 23(20); 6351–62. ©2017 AACR.
Learning, unlearning and relearning - knowledge life cycles in library and information science education

The knowledge life cycle is applied to two core capabilities of library and information science (LIS) education – teaching, and research and development. The knowledge claim validation, invalidation and integration steps of the knowledge life cycle are translated to learning, unlearning and relearning processes. Mixed methods are used to determine the extent and nature of learning, unlearning and relearning among academic faculty in graduate level library and information science programs. Mixed methods include (1) targeted interviews, (2) manual review of curriculum scope and coverage at seven universities, (3) semantic analysis of the content of 1,711 course syllabi, and (4) machine based analysis of learning, unlearning and relearning semantic markers in 432 journal articles drawn from twelve peer-reviewed journals. The research results provide a foundation for an open and national survey of LIS faculty in 2015. Research results suggest that there is evidence of learning, relearning and unlearning in teaching methods, but only evidence of learning in curriculum and course development, and research. Unlearning practices appear to be scarce in the field. This has implications for the disciplines ability to generate new knowledge and remain competitive in the knowledge economy.
Story of electromyography equipment

It all started in 1950 with the introduction of the first commercially available electromyography (EMG) system. From 1950 to 1973 was the era of the analog EMG systems: EMG signals were recorded, and subsequent analyses were carried out manually on film or paper. From 1973 to 1982, the first modular digital EMG systems were introduced. Dedicated analysis modules were introduced, but detailed analysis was still done on paper. In 1982, the first system controlled by a microprocessor was introduced. From 1982 to 1993, many new ways of analyzing EMG signals and basic reporting features were implemented in the EMG systems. Since 1993, personal computer technology has been used in EMG systems. Standard software and hardware components are used to record, analyze, and document EMG examinations. Since 1950, many people have influenced the development of new features in commercial EMG systems. However, within the last 3 decades, Erik Stålberg has always been in the forefront and has shown ways of implementing new methods for analyzing EMG activity or nerve signals. The development of new commercial EMG systems has been dependent on the technology introduced to the market at that particular period of time. This article only refers to systems that have been sold or are now being sold worldwide. © 2002 Wiley Periodicals, Inc. Muscle Nerve Supplement 11: S128–S133, 2002
Designing the Ideal Stent Stent cell geometry and its clinical significance in carotid stenting.

B alloon-expandable closed-cell stents were introduced for carotid artery stenting (CAS) as early as 1995. At that time, the cell structure of these stents was intended to support tissue and plaque against the vessel wall. This provided the necessary scaffolding for the stented carotid artery, as it did for the coronary or other peripheral arterial stenotic lesions (Figure 1). The postprocedure angiograms demonstrated the precision in which these stents restored the vessel to its normal dimension. Unfortunately, there was a 2% incidence of stent collapse.1 The stainless steel stent, when placed lower than the level of the mandible, could be externally compressed. For these reasons, the balloon-expandable stent for carotid occlusive disease was largely abandoned. Several valuable lessons, however, were learned from those early studies. Not only were radial rigidity and scaffolding important design features, but a range of expansion became a necessity. In the absence of articulation in the early designs, the flexibility and high profile of the stents prevented easy trackability. To improve the flexibility and the trackability, a connecting bridge between the two stents was integrated into the design (Figure 2). It was then observed that, depending on the length of the bridge, plaque prolapse could occur at the site. This observation would prove to be critical as we moved to the newer designs. When the noncrushable memory alloy nickel titanium (NiTi) stent was introduced, there were already several established design improvements. Flexibility, trackability, device profile, and security were essential for the delivery system. The stent design concept included vessel conformability, scaffolding, side branch preservation, visibility, and recoil control to minimize migration and foreshortening. To evaluate expansion and prolapse analysis, tests were designed to measure the flexion (ie, radial forces) that could occur under controlled pressure.
Sedation of children for electroencephalograms.

OBJECTIVE Sedation sometimes is necessary to perform an electroencephalogram (EEG) on a child. A dramatic decline in the need to use conscious sedation in our EEG laboratory prompted this review of our sedation experience. The purpose of this review was to determine the incidence of adverse sedation effects and to determine why the need for sedation had declined. METHODS All 513 attempts to administer sedation to children who were undergoing EEG studies during a 4-year period were reviewed retrospectively. Parameters studied included type and amount of the sedative agents, need for repeated dosing, successful completion of the EEG, and complications attributed to the sedative. RESULTS Sedation was attempted in 513 (18%) of 2855 EEGs performed during the 4-year period. Ninety-one percent of the EEGs performed with sedation were completed successfully. Chloral hydrate was the most frequently administered sedative. Complications (transient oxygen desaturation) occurred in 3 children, all of whom had recognized risk factors for airway compromise. The proportion of children who required sedation decreased from 32% to just 2% during that time period. CONCLUSION Sedation of children who are undergoing EEG examinations is effective and safe. Complications are infrequent. The need for sedation can be decreased greatly by adequate preparation and by creating a less-threatening, child-friendly environment in which to perform the study.
Four-Modality Therapy in Malignant Pleural Mesothelioma: A Phase II Study

Background: Treatment approaches in malignant pleural mesothelioma (MPM) patients range from mere palliation to aggressive anticancer therapy, and there is currently no consensus on the optimal therapeutic strategy. In 1999, we began a phase II study to investigate four-modality treatment of advanced stage MPM. Methods: From 1999 to 2004, 49 patients with International Mesothelioma Interest Group stage II–III MPM underwent four-modality treatment with intrapleural preoperative interleukin-2 (18 × 106 UI/day for 3 days), pleurectomy/decortication, intrapleural postoperative epidoxorubicin (25 mg/m2 for 3 days), interleukin-2 (18 × 106 UI/day for 3 days), adjuvant radiotherapy (30 Gy), systemic chemotherapy (cisplatin 80 mg/m2 day 1, gemcitabine 1250 mg/m2 days 1 and 8 for up to six courses) and long-term subcutaneous interleukin-2 (3 × 106 UI/day on 3 days per week). Results: Patients included 41 men and eight women with a median age of 61 years (range, 41–77). All patients were diagnosed with MPM by thoracoscopy before inclusion. There was no postoperative mortality. Postoperative morbidity included bleeding (n = 1) and arrhythmias (n = 3). After a median follow-up of 59 months (range, 14–81), 13 patients are still alive and the median actuarial survival is 26 months (31 and 21 months for stages II and III, respectively). The 2- and 5-year actuarial survival rates were 60.2% and 23.3%, respectively. Baseline Eastern Cooperative Oncology Group performance status significantly influenced survival time (p = 0.02). Conclusion: The four-modality treatment that we adopted for advanced-stage MPM was feasible, well tolerated by most of the patients, and produced a favorable median survival. This treatment approach warrants further investigation.
iShare: Balancing I/O performance isolation and disk I/O efficiency in virtualized environments

Performance isolation has long been a challenging problem for disk resource allocation in virtualized environments. While there have been many researches working on I/O performance isolation and disk utilization, none of them addresses the I/O performance isolation and disk utilization as a whole. To this end, we investigate the impact of current disk I/O performance isolation schemes on disk I/O utilization. Interestingly, our studies report that current isolation schemes bring unnecessary disk idle and reduce the overall disk I/O performance because of ignoring the disk states and characteristics of requests. Accordingly, we propose an adaptive proportional‐share I/O scheduling framework, named iShare, in virtualized environments. iShare not only ensures I/O performance isolation through proportionally allocating time slices according to the weights of virtual machines but also preserves high disk efficiency by detecting disk states and adaptively adjusting the time slice size based on characteristics of requests. We implement a prototype of iShare on the Xen platform. The experimental results show that iShare ensures I/O performance isolation while improving disk I/O efficiency, compared with Blkio (i.e., the default I/O performance isolation method in Xen), iShare increases disk I/O bandwidth by 58% and slightly improves the I/O performance isolation for the sequential write applications. Copyright © 2015 John Wiley & Sons, Ltd.
The effect of lateral ankle sprain on dorsiflexion range of motion, posterior talar glide, and joint laxity.

STUDY DESIGN Retrospective study. OBJECTIVE Assess range of motion, posterior talar glide, and residual joint laxity following ankle sprain in a population of athletes who have returned to unrestricted activity. BACKGROUND Lateral ankle sprains occur frequently in athletic populations and the reinjury rate may be as high as 80%. In an effort to better understand risk factors for reinjury, the sequelae to injury in a sample of college athletes were assessed. METHODS AND MEASURES Twelve athletes with a history of lateral ankle sprain within the last 6 months and who had returned to sport participation were tested. Only athletes who reported never injuring the contralateral ankle were included. The injured and uninjured ankles of subjects were compared for measures of joint laxity, ankle dorsiflexion range of motion, and posterior talar glide. Friedman's test of rank order was used to analyze the laxity measures and a MANOVA was used to assess the dorsiflexion and posterior talar glide measures. RESULTS Laxity was significantly greater at the talocrural and subtalar joints of the injured ankles. There were no significant differences in any of the ankle dorsiflexion measurements between injured and uninjured ankles, but posterior talar glide was significantly reduced in injured ankles as compared to uninjured ankles. CONCLUSION In our sample of subjects, residual ligamentous laxity was commonly found following lateral ankle sprain. Dorsiflexion range of motion was restored in the population studied despite evidence of restricted posterior glide of the talocrural joint. Although restoration of physiological range of motion was achieved, residual joint dysfunction persisted. Further research is warranted to elucidate the role of altered arthrokinematics after lateral ankle sprain.