Miracle-dz/UniFAR-FTUs huggingface dataset:
The long-term impact of a fire disaster on the physical and mental health of adolescents – a cohort study

The literature on adult trauma survivors demonstrates that those exposed to traumatic stress have a poorer physical health status than non-exposed individuals. Studies on physical health effects in adolescent trauma survivors, in contrast, are scarce. In the current study, it was hypothesized that adolescents who have been involved in a mass burn incident (N = 124) will demonstrate more physical and mental health problems than an unaffected cohort from the same community (N = 1,487). Health data were extracted from electronic medical records, covering one year pre-fire and four years post-fire. When compared to the pre-fire baseline, survivors showed significantly larger increases in mental, respiratory and musculosceletal problems than community controls during the first year after the fire, but not during the later years. Recent research demonstrates that trauma-exposed adults report a poorer health status than non-exposed individuals ( Boscarino, 2004; Kimerling, Clum, McQuery, & Schnurr, 2002; Oilman & Siegel, 2006). Research on physical health effects in younger age groups is scarce, however. In younger age groups, so far, most of the research has addressed mental health effects (Bolton, O'Ryan, Udwin, Boyle, & Yule, 2000; Broberg, Dyregrov, & Lilled, 2005; Goenjian et al., 2001; Goenjian et al., 2005; Yule et al., 2000). The current prospective, record-based study provided the opportunity to examine both physical and mental health problems in a group of adolescents who survived a mass burn incident which occurred in a café-bar‚ in Volendam, the Netherlands, on New Year’s Eve 2000. The bar was a popular meeting place for the town’s young people. When the fire began, the bar was seriously overcrowded. Fourteen adolescents died due to the fire and more than 200 victims were treated in hospitals (Welling et al., 2005). In order to separate the effects of psychological and physical trauma, the present study focusses on adolescents who were trapped in the fire, but did not suffer burns. These adolescents had experienced life-threat and witnessed how their peers were injured or died at This is a NIVEL certified Post Print, more info at http://www.nivel. eu Dorn, T. , Yzermans, J., Spreeuwenberg, P., Schilder, A. , Zee, J. van der. A cohort study of the long-term impact of a fire disaster on the physical and mental health of adolescents. Journal of Traumatic Stress: 2008, 21(2), 239-242 the scene. As a control group, adolescents from the same community who were not directly involved in the fire are examined.
Effect of cyclosporin and tacrolimus on kidney function in liver recipients

Introduction. Chronic renal failure is a significant issue regarding treatment of patients after liver transplantation. One of the factors determining the impaired renal function after liver transplantation is a long-term immunosuppressive therapy based on calcineurin inhibitors. The objective of the study was to evaluate the dynamics of renal function, depending on the use of various calcineurin inhibitors in the long-term postoperative period in liver recipients in real clinical practice. Materials and methods. A retrospective analysis of the renal function in patients operated in the State Public Health Budget Institution “Scientific Research Institute – S.V. Ochapovsky Regional Clinic Hospital № 1”, Krasnodar Region, was carried out. This article describes dynamics of creatinine level and glomerular filtration rate (GFR) in patients before liver transplant, as well as 6 months, 1, 2 and 3 years after surgery. GFR was calculated using the CKD-EPI formula (Chronic Kidney Disease Epidemiology Collaboration). Statistical processing of the results was carried out using the Statistica 10 software package. Results and discussion. Before transplantation, the level of creatinine in the blood plasma was 82.9±19.8 mmol/l, 6 months later a20.4% increase in creatinine was registered (p=0.004), 12, 24 and 36 months later – it increased by 24.8% (p=0.00001), 24.4% (p=0.0004), and 26.0% (p=0.0005), respectively. Both cyclosporine and tacrolimus caused an increase in the level of creatinine. Baseline GFR was 83.4±25.9, the reduction in GFR occurred in comparison with the baseline by 14.2% (p=0.0005), 18.8% (p=0.00001), 20.2% (p=0.00003), 22.6% % (p=0.00006) 6, 12, 24 and 36 months later, respectively. The degree of the decrease in GFR against the background of tacrolimus therapy did not differ significantly from that in case of cyclosporine. Verification of chronic kidney disease and the administration of statins were recorded in isolated cases. Conclusions. In liver recipients, the level of creatinine rises and GFR decreases. Reduction of kidney function occurs against the background of both inhibitors of calcineurin, in connection with which it is necessary to increase the doctors’ alertness for early detection of a decrease in glomerular filtration rate with further verification of chronic kidney disease.
Molekularne badania HPV w profilaktyce raka szyjki macicy

Accumulated evidence suggests that incorporating molecular DNA of high-risk HPV types detection into screening programs based on conventional or liquid cytology may bring significant health benefits, related to extremely high sensitivity and negative predictive value of such combined tests. It seems to be feasible and safe to extend the intervals between screening rounds. However efficacy of the cytology and DNA HPV based screening may be limited by high prevalence of transient HPV infections with little or any clinical significance.
Explanatory Machine Learning Model Plots for Epidemiological and Real-World Evidence Studies

For real-world evidence (RWE) and epidemiological studies, comparative effectiveness research (CER) provides actionable information for drug regulatory and health care decision-making. CER relies on white box statistical and machine learning (ML) models for estimating treatment effect and drug safety evaluation. Black box ML models are also powerful for generating better predictions, but how to interpret the model results is not straightforward. How should ML model results be presented to regulators to assure them that the results are accurate, fair, and unbiased? How should ML model findings be presented to end users to overcome the stigma of black box model bias? We provide a standardized interpretability plots framework for evaluating and explaining patient-level ML models using observational health-care data. The paper shows how to use SAS® Cloud Analytic Services action sets and model-agnostic interpretability tools available in SAS® Visual Data Mining and Machine Learning to explain the functional relationship between model features and target outcome variable. In addition to using the partial dependence and individual conditional expectation plots, we present some use cases and example code to demonstrate how plots that represent time-varying and non-time dependent variables interaction, cohort-period-feature effect, gender-age group stratification, beneficial and untoward effects of drug exposure, drug-disease interactions, and confounding-by-indication effect can be used to explain ML model results.
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

Abstract Secondary metabolites produced by bacteria and fungi are an important source of antimicrobials and other bioactive compounds. In recent years, genome mining has seen broad applications in identifying and characterizing new compounds as well as in metabolic engineering. Since 2011, the ‘antibiotics and secondary metabolite analysis shell—antiSMASH’ (https://antismash.secondarymetabolites.org) has assisted researchers in this, both as a web server and a standalone tool. It has established itself as the most widely used tool for identifying and analysing biosynthetic gene clusters (BGCs) in bacterial and fungal genome sequences. Here, we present an entirely redesigned and extended version 5 of antiSMASH. antiSMASH 5 adds detection rules for clusters encoding the biosynthesis of acyl-amino acids, β-lactones, fungal RiPPs, RaS-RiPPs, polybrominated diphenyl ethers, C-nucleosides, PPY-like ketones and lipolanthines. For type II polyketide synthase-encoding gene clusters, antiSMASH 5 now offers more detailed predictions. The HTML output visualization has been redesigned to improve the navigation and visual representation of annotations. We have again improved the runtime of analysis steps, making it possible to deliver comprehensive annotations for bacterial genomes within a few minutes. A new output file in the standard JavaScript object notation (JSON) format is aimed at downstream tools that process antiSMASH results programmatically.
Urban Scaling and Its Relation with Governance Structures and Future Prospects of Cities

We investigated the socioeconomic urban scaling behavior in three European Union countries: Denmark, Germany, and the Netherlands. In the case of Denmark our analysis relates to all 96 municipalities. We investigate the scaling of larger cities, municipalities within the Copenhagen agglomeration, and municipalities in rural areas. We also distinguish between municipalities with high and low centrality. We find superlinear scaling of the gross urban product with population size in all cases, with exponents between 1.14 and 1.23, and for municipalities in rural areas a surprisingly high value of 1.39. In Germany we distinguish between major cities of which the surrounding urban region belongs to the municipality of the city, the ‘Kreisfreie Städte’ (in total 106), and ‘Kreise’, i.e., regions around smaller cities consisting of several municipalities (in total 296). A striking finding is that the scaling exponents differ substantially from one region to another. We find in most cases a significant superlinear scaling with exponents up to 1.31. Our analysis convincingly shows that urban regions with one municipality (Kreisfreie Städte) perform significantly better than urban regions with fragmented governance structures (more than one municipality). Also we find a strong relation between the measured residuals of the scaling equations and the socio-economic position of a cities as perceived by expert reviews. For the Netherlands we focus on the group of the major cities (in total 21) with their agglomerations and on all 60 municipalities in the Province of Zuid-Holland (PZH). Again in both cases significant superlinear scaling is measured with exponents up to 1.26. Our earlier observation that one-governance urban areas perform better than multigovernance urban areas is confirmed and this is in line with the above mentioned findings for Germany.
Combining message encryption and authentication

The first part of the paper explains the need for combining message encryption and authentication. We begin with the example to emphasize the fact that privacyi¾? does not imply authenticity. Then we prove, one needs both privacy and authenticity, even if one's aim is just getting privacy. In the second part we present an overview of different methods for providing authenticated encryption (AE) i.e. generic compositions, single-pass modes and two-pass combined modes. We analyze what are the advantages and disadvantages of different AE constructions. In the third part of the paper we focus on noncei¾? based authenticated encryption modes. Our motivation is the wish to know the methodology of designing authenticated encryption mode of operation. We take into consideration a few most important properties, e.g. parallelizability, memory requirements and pre-processing capability. We analyze possibilities of choice of underlying encryption and authentication components and their order in a message we also try to answer. What does single-key mode really mean? Finally we mention the importance of provable security theory in the security of authenticated encryption modes.
PRESNOSŤ BUZOLOVÉHO MERANIA S VYUŽITÍM PRÍSTROJOV POUŽÍVANÝCH V ZOSTAVÁCH FIELD-MAP ACCURACY OF COMPASS MEASUREMENT WITH THE USE OF DEVICES APPLIED IN FIELD-MAP SETS

The paper contains the output of research aimed on applicability of compass measurement with the use of laser range-finder Impulse LR 200, electronic compass LTI MapStar Compass Module II and Trupulse 360B range-finder, which are a part of the Field-Map set. The research was aimed on the impact of measured azimuths and lengths precision and the measurement and computation methods on the final accuracy of the position evaluation. Lengths and azimuth measurement analyses showed that the main problem is the azimuth accuracy. In dependence on used equipment, and measurement and computation methods, there is a quite wide interval of mean coordinate error mxy values (0.23–2.95 m). The knowledge of these values framework can help to choose the optimal variant of the solution for the tasks where compass measurement can be applied. The best of the results show the possibility of use in tasks with higher accuracy demands, especially in combination with other measurement methods. In general it can be stated that compass measurement in areas without negative effects on the natural magnetism is the applicable method for the under-canopy forestry mapping and research. Kľúčové slová: buzolové meranie, presnosť, lesnícke mapovanie, Field-Map
Chats, Tweets and SMS in the SoNaR Corpus: Social Media Collection.

In this paper we discuss the compilation of a social media corpus with chats, tweets and SMS text messages as part of the SoNaR corpus, a 500-million word reference corpus of written Dutch, comprising many different text categories. Social media are more and more becoming part of everyday life, which makes the need for social media corpora an urgent matter for research. Special focus was addressed to the collection of metadata and intellectual property rights (IPR). IPR was obtained both through licenses with platform owners, and by consent of individual contributors. Recruitment of participants was done by means of free publicity. The data will be available for research and commercial use.
Un nouveau passage à l'échelle en recherche d'information

The quantity of numerised information that is being produced and consulted daily has considerably increased over the last few years; it is much more heteregeneous too. The quality and quantity of processing that can be applied to sources of information is inherently dependent on their sizes as well as the expectations of the users. This paper surveys some of the main problems that are directly related to the increase in size and variety of the collections of data. It also indicates some research issues in order to answer a seemingly new “scale up” problem in information management.
The Influence of Corporate External Environment on Strategy

The research examines empirically the influence of external environment in strategic management in small and medium-sized companies in Moravian Silesian Region. Questionnaires were selected for data collection. The survey results show that companies are affected by the environment. The influence of factors is different. The difference is due to the nature of business. Businesses are responding to the impact of factors in their strategies.
The effects of advanced maternal age on T‐cell subsets at the maternal–fetal interface prior to term labor and in the offspring: a mouse study

Women who conceive at 35 years of age or older, commonly known as advanced maternal age, have a higher risk of facing parturition complications and their children have an increased risk of developing diseases later in life. However, the immunological mechanisms underlying these pathological processes have yet to be established. To fill this gap in knowledge, using a murine model and immunophenotyping, we determined the effect of advanced maternal age on the main cellular branch of adaptive immunity, T cells, at the maternal–fetal interface and in the offspring. We report that advanced maternal age impaired the process of labor at term, inducing dystocia and delaying the timing of delivery. Advanced maternal age diminished the number of specific proinflammatory T‐cell subsets [T helper type 1 (Th1): CD4+IFN‐γ+, CD8+IFN‐γ+ and Th9: CD4+IL‐9+], as well as CD4+ regulatory T cells (CD4+CD25+FoxP3+ T cells), at the maternal–fetal interface prior to term labor. Advanced maternal age also altered fetal growth and survival of the offspring in early life. In addition, infants born to advanced‐age mothers had alterations in the T‐cell repertoire but not in CD71+ erythroid cells (CD3−CD71+TER119+ cells). This study provides insight into the immune alterations observed at the maternal–fetal interface of advanced‐age mothers and their offspring.
Proposal for Updated Nomenclature and Classification of Potential Causative Mechanism in Patent Foramen Ovale-Associated Stroke.

Importance Recent epidemiologic and therapeutic advances have transformed understanding of the role of and therapeutic approach to patent foramen ovale (PFO) in ischemic stroke. Patent foramen ovale is likely responsible for approximately 5% of all ischemic strokes and 10% of those occurring in young and middle-aged adults. Observations Randomized clinical trials have demonstrated that, to prevent recurrent ischemic stroke in patients with PFO and an otherwise-cryptogenic index ischemic stroke, PFO closure is superior to antiplatelet medical therapy alone; these trials have provided some evidence that, among medical therapy options, anticoagulants may be more effective than antiplatelet agents. Conclusions and Relevance These new data indicate a need to update classification schemes of causative mechanisms in stroke, developed in an era in which an association between PFO and stroke was viewed as uncertain. We propose a revised general nomenclature and classification framework for PFO-associated stroke and detailed revisions for the 3 major stroke subtyping algorithms in wide use.
Containing COVID‐19 in the Emergency Department: The Role of Improved Case Detection and Segregation of Suspect Cases

Abstract Objectives Patients with COVID‐19 may present with respiratory syndromes indistinguishable from common viruses. This poses a challenge for early detection during triage in the emergency department (ED). Over a 3‐month period, our ED aimed to minimize nosocomial transmission by using broader suspect case criteria for better detection and using appropriate personal protective equipment (PPE) for health care workers (HCWs). Methods All ED admissions with respiratory syndromes over a 3‐month period were tested for COVID‐19. The sensitivity and specificity of screening criteria in detecting COVID‐19 were assessed. A risk‐stratified approach was adopted for PPE usage in the ED, based on high‐risk “fever areas” and lower‐risk zones. When a case of COVID‐19 was confirmed, surveillance was conducted for potentially exposed patients and HCWs. Results A total of 1,841 cases presenting with respiratory syndromes required admission over the study period. Among these, 70 cases of COVID‐19 were subsequently confirmed. The majority (84.2%, 59/70) were detected at ED triage because they fulfilled suspect case criteria. Of these, 34 met the official screening criteria; an additional 25 were detected by the broader internal screening criteria. Over the 12‐week period, the cumulative sensitivity of internal screening criteria was 84.3% (95% confidence interval [CI] = 73.6% to 91.9%), whereas the sensitivity of the official screening criteria was 48.6% (95% CI = 36.4% to 60.8%). Given the broadened internal criteria, the preexisting ED “fever area” was insufficient and had to be expanded. However, there were no cases of nosocomial transmission from intra‐ED exposure, despite extensive surveillance. Conclusion Frontline physicians need to be given leeway to decide on the disposition of cases based on clinical suspicion during an ongoing outbreak of COVID‐19. If a broader criterion is used at ED triage, ED facilities and isolation facilities need to be readied to accommodate a surge of suspect cases. Usage of appropriate PPE is essential in minimizing nosocomial transmission.
Phosphorus toxicity disrupts Rubisco activation and reactive oxygen species defence systems by phytic acid accumulation in leaves.

Phosphorus (P) is an essential mineral nutrient for plants. Nevertheless, excessive P accumulation in leaf mesophyll cells causes necrotic symptoms in land plants; this phenomenon is termed P toxicity. However, the detailed mechanisms underlying P toxicity in plants have not yet been elucidated. This study aimed to investigate the molecular mechanism of P toxicity in rice. We found that under excessive inorganic P (Pi) application, Rubisco activation decreased and photosynthesis was inhibited, leading to lipid peroxidation. Although the defence systems against reactive oxygen species (ROS) accumulation were activated under excessive Pi application conditions, the Cu/Zn-type superoxide dismutase activities were inhibited. A metabolic analysis revealed that excessive Pi application led to an increase in the cytosolic sugar phosphate concentration and the activation of phytic acid synthesis. These conditions induced mRNA expression of genes that are activated under metal-deficient conditions, although metals did accumulate. These results suggest that P toxicity is triggered by the attenuation of both photosynthesis and metal availability within cells mediated by phytic acid accumulation. Here, we discuss the whole phenomenon of P toxicity, beginning from the accumulation of Pi within cells to death in land plants. This article is protected by copyright. All rights reserved.
Coal Discrimination Analysis using Tandem Laser-Induced Breakdown Spectroscopy and Laser Ablation Inductively Coupled Plasma Time of Flight Mass Spectrometry.

The contribution and impact of combined laser ablation inductively coupled plasma time of flight mass spectrometry (LA-ICP-TOF-MS) and laser induced breakdown spectroscopy (LIBS) were evaluated for the discrimination analysis of different coal samples. This Tandem approach allows simultaneous determination of major and minor elements (C, H, Si, Ca, Al, Mg, etc), and trace elements (V, Ba, Pb, U, etc.) in the coal. The research focused on coal classification strategies based on prin-ciple component analysis (PCA) combined with K-means clustering, partial least squares discrimination analysis (PLS-DA), and support vector machine (SVM) for analytical performance. Correlation analyses performed from TOF mass and LIBS emission spectra from the coal samples showed that most major, minor, and trace elements emissions had negative correla-tion with the volatile content. Suitable variables for the classification models were determined from these data. The individ-ual TOF data, LIBS data, and the combined data of TOF and LIBS, respectively, as the input for different models were analyzed and compared. In all cases, the results obtained with the combined TOF and LIBS data were found to be superior to those obtained with the individual TOF or LIBS data. The nonlinear SVM model combined with TOF and LIBS data pro-vided the best coal classification performance, with a classification accuracy of up to 98%.
Cytotoxic compounds from the stems of Diospyros ehretioides and their bioactivity

Abstract A new (naphthalenyl)methyl acetate, (1,4,5-trimethoxynaphthalen-2-yl)methyl acetate (1) and (±)-4,5-dihydroxy-2-methyltetralone (2) were isolated together with five lupane triterpenes (3–7), naphthoquinone derivatives (8–13), coumarins (14 and 15) and a vanillic acid (16) from the stems of Diospyros ehretioides. Their structures were established through spectroscopic analysis, IR, 1D and 2D NMR. Both 1 and 2 displayed significant cytotoxicity against three cancer cell lines including HeLa, HCT116 and MCF-7, with IC50 values in the range of 5.05–15.90 µg/mL, while 16 exhibited moderate cytotoxicity against HeLa and HCT116 cell lines and was not toxic to Vero cells. Graphical Abstract