Miracle-dz/UniFAR-FTUs huggingface dataset:
Dermatofibrosarcoma protuberans atrófico: a propósito de un caso

El dermatofibrosarcoma protuberans (DFSP) es un tumor maligno mesenquimal poco comun, que surge en la dermis y se caracteriza por una latencia prolongada, lo que retrasa su deteccion. La forma atrofica o morfea simil es una forma rara de la enfermedad que se asemeja a otras lesiones benignas, como la morfea, atrofodermia idiopatica, anetodermia o lipoatrofia. Se comporta como un DFSP clasico y predomina en adultos jovenes o de edad media. Tiene un crecimiento infiltrativo lento y alta tasa de recurrencia local si no se extirpa completamente. Las metastasis son raras y ocurren luego de multiples recurrencias locales. El tratamiento de primera linea es la escision quirurgica. Para detectar recurrencias es necesario el seguimiento a largo plazo. Reportamos un caso de DFSP atrofico; el diagnostico se alcanzo mediante hallazgos clinicos, histopatologicos e inmunohistoquimicos. El tumor fue removido en su totalidad y se le da seguimiento a la paciente
Effect of the menstrual cycle on pain experience associated with periodontal therapy: randomized, pilot study.

OBJECTIVES The aim of this pilot cross-over study was to compare preliminarily the pain perception of female patients undergoing periodontal debridement during menstrual or pre-menstrual phases (peri-menstrual period) with that observed during mid-menstrual phase (post-menstrual period). MATERIALS AND METHODS Twenty women with moderate-to-advanced chronic periodontitis and regular menstrual cycles were asked to complete Corah's Dental Anxiety Scale (DAS) during the first debridement visit. Patients were randomly assigned to receive their first debridement visit during either their peri-menstrual or post-menstrual period. Debridement was performed in bilateral quadrants of patients during the periods. Pain levels for each quadrant were assessed with a Visual Analogue Scale (VAS), after each debridement visit. RESULTS There was no significant correlation of order of treatment in the intensity of perceived pain during the periods (p<0.05). The median VAS scores were 22.0 and 15.2 mm in the peri-menstrual and the post-menstrual period, respectively. Increase in pain perception among females during their peri-menstrual period was significantly greater than their post-menstrual period (p<0.05). CONCLUSION No clinical conclusions can be drawn at this stage as this pilot study did not have a sufficiently broad population to generalize these observations to all female periodontal patients. Providing clinicians with information about patients' menstrual cycle during debridement can alter the pain experience.
Nonpolar interactions of thrombin and its inhibitors at the fibrinogen recognition exosite: thermodynamic analysis.

Nonpolar interactions play a major role in the association of the fibrinogen recognition exosite of thrombin with the C-terminal fragment (55-65), Asp-Phe-Glu-IIe-Pro-Glu-Glu-Tyr-Leu-Gln, of hirudin, which is a naturally occurring thrombin inhibitor. The thermodynamic details (free energy, enthalpy, entropy, and heat capacity) of the molecular recognition are studied by using five analogs of a synthetic bivalent thrombin inhibitor (P552), tert-butylbenzensulfonyl-Arg-(D-pipecolic acid)-(12-amino-dodecanoic acid)-(gamma-aminobutyric acid)-hirudin55-65. The residue of PheH56, IleH59, ProH60, TyrH63, or LeuH64 in hirudin 55-65 segment is substituted by Gly in each analog in order to elucidate the contributions of these nonpolar side chains. The results show that the interactions of these nonpolar side chains with thrombin are enthalpy-driven, except for the contribution of the PheH56 side chain which is entropy-driven. Interestingly, molecular modeling predicts a large conformational change due to the Gly substitution of PheH56. In analyzing the correlation among the thermodynamic and structural properties of the nonpolar interaction, a good correlation is observed between the binding free energy and the hydrophobicity of the molecular surface; i.e., tighter binding is observed as more nonpolar atoms are buried and more polar atoms are exposed upon molecular association.
ACT II.

___________________________________ ACT II Read ACT II of the play and make notes. Scene One I. WHEN? – TIME: ____ ________________________________________________________________________ II. WHERE? – PLACE __________________________________________________________________________ III. WHO? – ___________________________________________________________________________________ IV. WHAT? – Short summary ______________________________________________________________________________________ ______________________________________________________________________________________ ______________________________________________________________________________________ _______________________________________________________________________________________________________ _______________________________________________________________________________________________________ _______________________________________________________________________________________________________ ____________________________________________________________________________________________ ____________________________________________________________________________________________
Physical activity and adolescents: an exploratory randomized controlled trial investigating the influence of affective and instrumental text messages.

OBJECTIVE The present study attempts to develop and pilot the feasibility and efficacy of a novel intervention using affective messages as a strategy to increase physical activity (PA) levels in adolescents. Design An exploratory pilot randomized control trial was used to compare behaviour change over 2 weeks. A modified form of the International Physical Activity Questionnaire was used to assess PA behaviour. A total of 120 adolescents (16-19 years) from 4 sixth forms in West Yorkshire completed the field-based study. METHOD Participants were randomly assigned to one of three experimental conditions, or the control condition (N=28). Participants in experimental conditions received 1 short messaging service (SMS) text message per day over the 2 weeks, which included manipulations of either affective beliefs (enjoyable/unenjoyable; N=31), instrumental beliefs (beneficial/harmful; N=30), or a combination of these (N=31). Control participants received one SMS text message per week. Outcomes were measured at baseline and at the end of the 2 week intervention. RESULTS PA levels increased by the equivalent of 31.5 minutes of moderate (four metabolic equivalent) activity per week during the study. Main effects of condition (p=.049), and current physical activity level (p=.002) were identified, along with a significant interaction between condition and current activity level (p=.006). However, when the sample was split at baseline into active and inactive participants, a main effect of condition remained for inactive participants only (p=.001). Post hoc analysis revealed that inactive participants who received messages targeting affective beliefs increased their activity levels significantly more than the instrumental (p=.012), combined (p=.002), and control groups (p=.018). CONCLUSION Strategies based on affective associations may be more effective for increasing PA levels in inactive individuals.
Falsely low direct HDL-cholesterol results in a patient with dysbetalipoproteinemia.

Direct methods for measuring HDL-cholesterol (HDL-C) are becoming more widely used because of their labor savings and favorable performance characteristics. We investigated three methodologies for direct HDL-C measurements. All three contain an initial reagent to block measurement of cholesterol in lipoproteins other than HDL, followed by a second reagent to measure HDL-C. The performance of each of these assays has been evaluated previously (1)(2)(3)(4)(5)(6)(7)(8). All of these direct assays appear to be relatively free of common interferences; however, triglycerides >10 g/L may affect recoveries. There are minimal published data on these new direct methods with patients who have a dyslipidemia or are receiving lipid-modifying drugs. In this report, we describe a patient with type III hyperlipidemia for whom three direct HDL-C assays yielded erroneously low results compared with traditional HDL-C methods. We analyzed a specimen from a 69-year-old man, using a direct HDL-C assay, and obtained a value that was less than the 40 mg/L detection limit of the assay. The patient had no signs or symptoms such as large orange tonsils, corneal opacities, or relapsing polyneuropathy, compatible with primary hypoalphalipoproteinemia. His medical history was remarkable for chronic obstructive pulmonary disease, peripheral vascular disease, recurrent deep vein thrombosis, congestive heart failure, coronary artery disease, hypertension, and an unspecified hyperlipidemia. His current medications included aspirin, coumadin, digoxin, diltiazem, furosemide, albuterol/ipratropium inhaler, and simvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor. He had consumed no alcohol for at least 1 year. A review of results for hepatic disease tests for the past 4 years revealed serum concentrations of aspartate aminotransferase, alanine aminotransferase, and total bilirubin within the appropriate reference intervals. Alkaline phosphatase values were 1.3- to 1.9-fold higher than the upper limit of normal over this same time period. Additional …
A new last aggregation compromise solution approach based on TOPSIS method with hesitant fuzzy setting to energy policy evaluation

Utilizing renewable energies is identified as one of significant issues for economical and social significance in future human life. Thus, choosing the best renewable energy among renewable energy candidates is more important. To address the issue, multi-criteria group decision making (MCGDM) methods with imprecise information could be employed to solve these problems. The aim of this paper is to propose a new compromise solution approach based on technique for order preference by similarity to ideal solution (TOPSIS) method under evaluations of a group of experts with hesitant fuzzy information. The hesitant fuzzy set (HFS) is a modern fuzzy set which could help the experts by providing some membership degrees for renewable energy candidates under the evaluation criteria to margin of errors. Also, weights of each expert and criterion are determined by proposing extended hesitant fuzzy entropy and maximizing deviation methods based on hesitant fuzzy Euclidean-Hausdorff distance measure. In addition, the judgments (preferences) of experts are aggregated in the final step to prevent the loss of data. Finally, an illustrative example about the energy policy selection is presented to demonstrate the procedure of the proposed decision approach. Also, a comparative analysis is provided with the recent decision method of the literature to show the capability of the proposed approach.
Apoptotic signal transduction: emerging pathways.

Apoptosis is a counterbalance to mechanisms of cell proliferation and is critically important in regulation of the immune system, development, and normal tissue homeostasis. Mammalian signal transduction pathways affecting apoptosis are more complex than their counterparts in the nematode Caenorhabditis elegans, a valuable model system that has provided powerful initial insights into key molecules regulating apoptosis. Despite this complexity, substantial progress has been made in recent years towards defining the nature and detail of signalling pathways bringing about apoptosis in mammalian cells. In particular, the identity and precise substrate specificities of a large family of caspase enzymes, implicated as critical components of the apoptotic machinery, have been defined. In addition, the mechanism by which the cell surface Fas receptor mediates induction of apoptosis, via activation of caspases, has recently been elucidated. A prominent role for mitochondria in cell death pathways has also recently emerged, a clear theme being that mitochondria can trigger degradative events by the release of apoptogenic proteins (e.g., cytochrome c) from the intermembrane space to the cytosol. This review focuses on recent progress in these areas and discusses integration of this knowledge in our overall understanding of the processes that control apoptosis.
Ultrasound for central venous cannulation: economic evaluation of cost effectiveness.

Study population The study population comprised a hypothetical cohort of 1,000 patients. The characteristics of the population were not described in detail. The authors reported that patients in emergency scenarios were excluded from the study, as were high-risk patients. Also excluded were those who faced higher risk of complications, such as infants, neonates, and adult patients in whom cannulation is more difficult to perform (e.g. obese or short-necked patients). More information on the study population can be found in the three papers cited in the 'Other Publications of Related Interest' section.
Sociodemographic Correlates of Tobacco Consumption in Rural Gujarat, India

Background. The purpose of this study was to examine occupation-, education-, and gender-specific patterns of tobacco use and knowledge of its health effects among 23,953 rural Asian Indians ≥18 years in Gujarat. Methodology. A statewide, community-based, cross-sectional survey was conducted in 26 districts of Gujarat (December 2010–May 2015), using face-to-face interviews by trained community health workers called SEVAKS. Results. Mean age was 39.8 ± 15.2 years. Eighteen percent of respondents used tobacco in various forms. Tobacco consumption was significantly higher among males (32%), 18–34 years' age group (35%), those who were self-employed (72%), and those with elementary education (40%). The prevalence was 11 times higher among males than females (95% CI = 9.78, 13.13). Adjusted ORs for tobacco use showed strong gradient by age and educational level; consumption was lower among the illiterates and higher for older participants (≥55 years). Tobacco consumption also varied by occupation; that is, those who were self-employed and employed for wages were more likely to use tobacco than those who were unemployed. Knowledge of health effects of tobacco lowered the odds of consumption by 30–40%. Conclusions. Effective educational programs should be tailored by gender, to improve knowledge of health risks and dispel myths on perceived benefits of tobacco.
Large Scale Identification and Quantitative Profiling of Phosphoproteins Expressed during Seed Filling in Oilseed Rape*S

Seed filling is a dynamic, temporally regulated phase of seed development that determines the composition of storage reserves in mature seeds. Although the metabolic pathways responsible for storage reserve synthesis such as carbohydrates, oils, and proteins are known, little is known about their regulation. Protein phosphorylation is a ubiquitous form of regulation that influences many aspects of dynamic cellular behavior in plant biology. Here a systematic study has been conducted on five sequential stages (2, 3, 4, 5, and 6 weeks after flowering) of seed development in oilseed rape (Brassica napus L. Reston) to survey the presence and dynamics of phosphoproteins. High resolution two-dimensional gel electrophoresis in combination with a phosphoprotein-specific Pro-Q Diamond phosphoprotein fluorescence stain revealed ∼300 phosphoprotein spots. Of these, quantitative expression profiles for 234 high quality spots were established, and hierarchical cluster analyses revealed the occurrence of six principal expression trends during seed filling. The identity of 103 spots was determined using LC-MS/MS. The identified spots represented 70 non-redundant phosphoproteins belonging to 10 major functional categories including energy, metabolism, protein destination, and signal transduction. Furthermore phosphorylation within 16 non-redundant phosphoproteins was verified by mapping the phosphorylation sites by LC-MS/MS. Although one of these sites was postulated previously, the remaining sites have not yet been reported in plants. Phosphoprotein data were assembled into a web database. Together this study provides evidence for the presence of a large number of functionally diverse phosphoproteins, including global regulatory factors like 14-3-3 proteins, within developing B. napus seed.
Chondrules with Peculiar REE Patterns: Implications for Solar Nebular Condensation at High C/O

Rare earth element (REE) data from two ordinary chondrite chondrules show distinct negative chondrite-normalized concentration anomalies of samarium, europium, and ytterbium. The peculiar patterns may be the result of REE gas/solid fractionation at an oxygen fugacity lower than has been assumed for the canonical solar nebula. We suggest that the two ordinary chondrite chondrules acquired the fractionated REE patterns by incorporation of highly reduced, ultrarefractory condensates in their precursors. This interpretation implies that high-temperature condensation processes occurred in nebular environments with a strong deficit in oxygen, such as regions with an enhanced carbon/oxygen ratio.
Constrained model predictive control for mobile robotic manipulators

SUMMARY This paper discusses the application of a constraint-based model predictive control (MPC) to mobile manipulation tracking problems. The problem has been formulated so as to guarantee offset-free tracking of piecewise constant references, with convergence and recursive feasibility guarantees. Since MPC inputs are recomputed at every control iteration, it is possible to deal with dynamic and unknown scenarios. A number of motion constraints can also be easily included: Acceleration, velocity and position constraints have been enforced, together with collision avoidance constraints for the mobile base and the arm and field-of-view constraints. Such constraints have been extended over the prediction horizon maintaining a linear-quadratic formulation of the problem. Navigation performance has been improved by devising an online algorithm that includes an additional goal to the problem, derived from the classical vortex field approach. Experimental validation shows the applicability of the proposed approach.
Seroepidemiological study of retroviruses (HTLV‐I/II, HIV‐1, HIV‐2) in the Department of Atacora, Northern Benin

A seroepidemiological survey to determine the prevalence of retrovirus infection (HTLV‐I/II, HIV‐I, HIV‐2) by representative sampling of the general population in the Department of Atacora in north‐western Benin is reported. The seroprevalence rate of HTLV‐I in this sample was at 1.86% (95% CI 1.20–2.52%). This is in agreement with prevalence rates reported from neighbouring countries of the sub‐region. No sera were found positive for HTLV‐II. Seropositivity to HIV‐I was 0.3%; HIV‐2 seropositivity was not encountered.
Artificial intelligence in radiation oncology treatment planning: a brief overview

Among medical specialties, radiation oncology has long been an innovator and early adopter of therapeutic technologies. This specialty is now situated in prime position to be revolutionized by advances in artificial intelligence (AI), especially machine and deep learning. AI has been investigated by radiation oncologists and physicists in both general and niche radiotherapy planning tasks and has often demonstrated performance that is indistinguishable from human experts, while substantially shortening the time required to complete these tasks. We sought to review applications of AI to domains germane to radiation oncology, namely: image segmentation, treatment plan generation and optimization, normal tissue complication probability modeling, quality assurance (QA), and adaptive re-planning. We sought likewise to consider obstacles to AI adoption in the radiotherapy clinic, now primarily political, legal, and ethical rather than technical in nature.
Catecholamine-induced cAMP response in streptozotocin-induced diabetic rat liver.

UNLABELLED The effect of prolonged diabetic state on catecholamine-induced adenosine 3',5'-monophosphate (cAMP) response in the rat liver was examined using isolated liver perfusion. Epinephrine- or isoproterenol-induced cAMP production was enhanced (10-fold of the control) in the liver from extremely emaciated (intraperitoneal adipose tissue was absent completely) diabetic rats 4 weeks after streptozotocin-injection kept without insulin, but not from adipose tissue-present diabetic rats. Glucagon-induced cAMP production was decreased in the diabetic rat liver 4 weeks after streptozotocin regardless of the presence or absence of adipose tissue. Secretin-induced cAMP production was also decreased in the adipose tissue-absent diabetic rat liver. Plasma levels of glucose or insulin were not different between adipose tissue-present and -absent diabetic rats. Liver dysfunction (elevated AST and ALT levels) was observed 1 week after streptozotocin-injection, and worsened at 4 weeks. Forskolin-induced production of cAMP, and oxymetazoline (an alpha 2-adrenergic agonist)-induced suppression of it were not different among the control, newly diabetic (1 week after streptozotocin-injection), and the adipose tissue-absent diabetic rat liver. IN CONCLUSION 1) enhanced beta-adrenergic, and decreased glucagon- or secretin-induced cAMP production seems to be caused by different mechanisms; 2) the prolonged severe diabetic state losing adipose tissue may cause a considerable change in metabolism and the characteristics of hepatocyte, and lead to enhanced beta-adrenergic cAMP production.
Mutations of the granulocyte‐colony stimulating factor receptor in patients with severe congenital neutropenia are not required for transformation to acute myeloid leukaemia and may be a bystander phenomenon

Point mutations of the granulocyte‐colony stimulating factor receptor (G‐CSFR) resulting in an abnormally truncated receptor have been implicated in the pathogenesis of some cases of severe congenital neutropenia (SCN) and in the transformation of SCN to acute myeloid leukaemia (AML). We report here studies in 11 patients with SCN. No mutations were detected in the one patient who developed AML indicating that development of such mutations is not a prerequisite for transformation. Truncation mutations were detected in a minor percentage of transcripts from two other patients. In one patient the mutation has been constant at a low level (5–10% of total mRNA and 2/40 myeloid colonies) for 2 years. In the other patient the mutation was acquired, remained present at low levels for nearly 3 years and then spontaneously disappeared. Both patients had polyclonal haemopoiesis. We hypothesize that these mutations do not cause SCN, are randomly acquired with the mutant clone being expanded to detectable levels by high levels of exogenous or endogenous G‐CSF, and may disappear by clonal succession. In a pre‐leukaemic marrow the mutated subclone could achieve high levels, but this does not necessarily indicate a primary role of the mutant receptor in the leukaemogenic process.
Circadian regulation of growth hormone secretion after treatment in acromegaly.

In eight patients who underwent transsphenoidal adenomectomy for acromegaly,baselineplasma GH levels were consistently less than 8 ng/ml during 1–4 yr postoperatively. Plasma GH was measured every 20 min for 24 h, and the responses to oral glucose, iv TRH, and oral bromocriptine were examined during the follow—up. The 2-h mean (±SD) GH value varied from 1.1 ± 0.9 to 10.8 ± 4.9 ng/ml. Statistical analysis of these mean values allowed identification of two groups of patients. In each group I patient (five cases), the mean 24-h GH level was less than or equal to 2.0 ng/ml. One to four daytime GH secretion peakswith intervening periods oflow secretory activity were observed. In all five cases, a significant nocturnal GH rise was found; this rise coincided with the onset of deep sleep in only two patients. Responses to dynamic tests returned t o normal after surgery in this group. In group II patients (three cases), the mean (±SD) 24-h GH levels varied from 46 ± 1.0 to 10.8 ± 4.9 ng/ml. Two patients presented .