Miracle-dz/UniFAR-FTUs huggingface dataset:
Is an Epic Pluvial Masking the Water Insecurity of the Greater New York City Region

AbstractSix water emergencies have occurred since 1981 for the New York City (NYC) region despite the following: 1) its perhumid climate, 2) substantial conservation of water since 1979, and 3) meteorological data showing little severe or extreme drought since 1970. This study reconstructs 472 years of moisture availability for the NYC watershed to place these emergencies in long-term hydroclimatic context. Using nested reconstruction techniques, 32 tree-ring chronologies comprised of 12 species account for up to 66.2% of the average May–August Palmer drought severity index. Verification statistics indicate good statistical skill from 1531 to 2003. The use of multiple tree species, including rarely used species that can sometimes occur on mesic sites like Liriodendron tulipifera, Betula lenta, and Carya spp. , seems to aid reconstruction skill. Importantly, the reconstruction captures pluvial events in the instrumental record nearly as well as drought events and is significantly correlated to precipitation.
In Silico Receptorome Screening of Antipsychotic Drugs

The recent availability of a complete interaction matrix between 13 antipsychotic drugs and 34 protein targets (Roth et al. Nat. Rev. Drug Discov. 2004, 3, 353–359) allows to assess the performance of computational methods on their ability to anticipate the entire affinity profile of drugs across multiple targets. The analyses reveal that our current implementations, based on the similarity of drugs against a reference set of small molecules for which pharmacological data is available in the public domain, are able to predict 65 % of the 442 affinities within 1‐log unit error, with a level of precision above 92 %. In spite of the relatively small scale of this validation study, the results are indicative that in silico receptorome screening of drugs offers an efficient and cost‐effective complement to in vitro screening.
Control of the motion of an acrobot approaching a horizontal bar

In this paper, we consider the motion of a gymnast approaching a horizontal bar and focus on the acrobot. In the stance phase, we set the jump with a desired speed direction and a desirable angular momentum as the control objective, and achieve it by introducing an output feedback control with a suitably chosen output function. In the flight phase, a suitable desired trajectory enables us to control the posture when the acrobot approaches it. Finally, numerical simulations are shown to demonstrate this motion.
Mensuração de custos intangíveis: uma análise prática

O objetivo desta pesquisa e a mensuracao de custos intangiveis. A partir de uma revisao da literatura sobre Estrategia, Ativos Intangiveis, Fatores Intangiveis, Custos Intangiveis, Custeio ABC e Matriz de Relacao, aplicou-se o modelo proposto por Diehl (1997) para a mensuracao de custos intangiveis. Amplia-se o modelo com a inclusao da priorizacao dos fatores intangiveis por meio de tecnicas qualitativas como: entrevista nao estruturada e matriz de relacoes, a partir da selecao dos atributos constantes na estrategia empresarial comparados com os fatores intangiveis mais citados pelos gestores. Tal modelo foi aplicado na empresa de Trens Urbanos de Porto Alegre (Trensurb S/A). O periodo para analise dos custos intangiveis foi de novembro de 2007 a outubro de 2008. A partir da selecao do fator intangivel imagem empresarial foi possivel mensurar o que foi gasto para manter esse fator nos ultimos doze meses pela organizacao. Com a utilizacao pratica do modelo, pode-se constatar que ele e aplicavel, sobretudo em organizacoes cuja sistematica do Custeio ABC ja esta inserida ou que ja exista sistema integrado de informacoes nos moldes do custeio por atividades.
Regulation of the herpesvirus saimiri (HVS) delayed-early 110-kilodalton promoter by HVS immediate-early gene products and a homolog of the Epstein-Barr virus R trans activator

We have reported previously the detection of two stable immediate-early (IE) transcripts that accumulate in cycloheximide-treated cells infected with herpesvirus saimiri (HVS). These are the 1.6-kb mRNA from the 52-kDa gene (which is homologous to the BSLF2-BMLF1 gene of Epstein-Barr virus) and the 1.3-kb mRNA from the HindIII-G fragment of virus DNA. In order to study the roles of the HVS IE gene products in the progression of a lytic infection, the promoter region of the delayed-early 110-kDa gene of HVS was sequenced, the transcription initiation site was mapped by RNase protection, and the promoter sequences were cloned upstream of the chloramphenicol acetyltransferase (CAT) gene. Sequences between -447 and +37 (relative to the 110-kDa transcription initiation site) were sufficient for response to HVS superinfection of transfected cells, but the 110-kDa promoter was activated only poorly by the 52-kDa and HindIII-G IE (IE-G) proteins in cotransfection experiments. However, a distinct region of the genome, EcoRI-D (15 kbp), was able to activate 110-kDa-CAT expression relatively efficiently in similar experiments. A 4.7-kbp PstI fragment encoding this function was isolated and sequenced, and further subcloning identified the gene encoding the EcoRI-D trans activator. This gene, which we now designate HVS.R, is homologous to the BRLF1-encoded transcriptional effector of Epstein-Barr virus.
THE RELATIONSHIP BETWEEN REPRODUCTION INDICATORS AND THE STRUCTURE OF FOOD RATION , IN THE DAIRY COWS FARMS

There is always a correlation between the exact feeding and fertility indicators [1]. Nutrition affects the fertility of the cows, especially during the first three months after calving [2, 6]. In almost 50 % of cases indicators of hypo-fertility depend from dietary mistakes and this was and is a current topic of increasing interest for specialists and farmers [7]. The study aims to clarify the relationship between food ration structure and reproduction indicators, in concrete breeding conditions in cows’ farms for milk production. During the period March 2015 March 2016, relationship between reproduction indicators and the structure of feed rations in five cows’ farm, with each over 25 cows were studied. The indicators of pre-service period (PSP), days open (DO) and the average index of copulation (IC), were confronted with mineral content of elements calcium (Ca), phosphor (P) and magnesium (Mg). The reproduction indicators were calculated with the standard methods, meanwhile the mineral content elements in the food rations were calculated according to McDonald [7]. The data obtained were processed statistically with ANOVA method and were prepared graphs of linear regression. After grouping and statistical development, gained results indicated that there is a relationship between the indicators we were studying. The strength relationships was found between open days (OD) and copulation index (IC) with the level of Ca in the food ration (r = 0.840 and r = 0.832 respectively). Pre service period seems to be unaffected from the composition and structure of feed rations. Relationships which have to be evaluated too, are between the level of P with days open (DO) and copulation index (IC) (r = 0.397 and r = 0.454 respectively). The results are indicating that levels of Mg seems to be insignificant for the days open indicator and the pre service period (r = 0.124 and r = 0.211). Our data are approximately the same with the conclusions of other authors. In cows feeding, the structure and the composition of the food rations are the most estimated elements. From the indicators of the structure of food ration in cows, seems that a stronger impact in reproduction indicators has the content of CA and P. Pre-service period (PSP) seems to be not affected by the structure and composition of the food ration. The composition and content of mineral elements in the food ration can be used for prognostic purposes.
Clinical two‐photon microendoscopy

Two‐photon medical imaging has found its way into dermatology as an excellent method for noninvasive skin cancer detection without need of contrast agents as well as for in situ drug screening of topically‐applied cosmetical and pharmaceutical components. There is an increasing demand to apply the multiphoton technology also for deep‐tissue skin imaging as well as for intracorporal imaging. We report on the first clinical use of multiphoton endoscopes, in particular of a miniaturized rigid two‐photon GRIN lens endoscope. The microendoscope was attached to the multiphoton tomograph DermaInspect and employed to detect the extracellular matrix proteins collagen and elastin in the human dermis of volunteers and patients with ulcera by in vivo second harmonic generation and in vivo two‐photon autofluorescence. Microsc. Res. Tech., 2007. © 2007 Wiley‐Liss, Inc.
Fibrilación auricular en un hospital general

Juan Manuel Cortes-Ramirez,* Juan Manuel de Jesus Cortes-de la Torre,** Raul Arturo Cortes-de la Torre,*** Jesus Uriel Cisneros-Contreras,* Baldomero Javier Mendez-Reyes,**** Alfredo Salazar-de Santiago,***** Ma. del Carmen Aceves,**** Elda Mayorga-Garcia,**** Adrian Jimenez,****** Paloma Barajas-Prieto,**** Gabriela Guerrero-Martinez,**** Mayra Lizbeth Hernandez-Trujillo,**** Raquel de la Torre-Murillo
Mapping subcortical extrarelay afferents onto primary somatosensory and visual areas in cats

Projections from the claustrum (Cl) and the thalamic anterior intralaminar nuclei (MN) to different representations within the primary somatosensory (S1) and visual (V1) areas were studied using the multiple retrograde fluorescent tracing technique. The injected cortical regions were identified electrophysiologically. Retrograde labeling in Cl reveals two different projection patterns. The first pattern is characterized by a clear topographic organization and is composed of two parts. The somatosensory Cl shows a dorsoventral progression of cells projecting to the hindpaw, forepaw, and face representations of S1. The visual Cl has cells projecting to the vertical meridian representation of V1 surrounded dorsally by neurons projecting to the representation of retinal periphery. A second pattern of Cl projections is composed of neurons that are distributed diffusely through the nucleus. In both somatosensory and visual sectors, these intermingle with the topographically projecting cells. Neurons retrogradely labeled from cortical injections are always present in the AIN. In the central medial nucleus, the segregation of modality is evident: The visual‐projecting sector is dorsal, and the somatosensory is ventral. Projections from the central lateral nucleus display detectable somatotopic and retinotopic organization: Individual regions are preferentially connected with specific representations of S1 or V1. In the paracentral nucleus, no clear regional preferences are detectable. Also performed were comparisons of the proportions of neurons projecting to different sensory representations. Projections to V1 from both AIN and Cl are biased towards the retinal periphery representation. S1 projection preference is for the forepaw representation in Cl and for the hindpaw in the AIN. The quantitative analysis of multiply labeled cells reveals that, compared to Cl, the AIN contains a higher proportion of neurons branching between different representations of S1 or V1. The concept of topographic vs. diffuse projecting systems is reviewed and discussed, and functional implications of quantitative analysis are considered. © Wiley‐Liss, Inc.
Effect of corticotropin on aldosterone excretion and plasma renin in normal subjects, in essential hypertension and in primary aldosteronism.

ABSTRACT Administration of a large dose of ACTH caused an acute increase in aldosterone excretion in normal subjects, in cases of uncomplicated essential hypertension and in primary aldosteronism. Plasma renin levels were unaltered. The continued administration of ACTH for several days led to a fall in aldosterone excretion to below the control value in most cases, even when the subjects were maintained on a low salt diet. On the day after ceasing ACTH treatment, aldosterone transiently fell to even lower levels, which were also inappropriate to the low sodium intake. These various changes in aldosterone excretion produced by ACTH administration cannot be explained by any concurrent changes in activity of the renin-angiotensin system. The data also suggest that any changes in electrolyte metabolism induced by ACTH are only a minor influence in causing the depression in aldosterone secretion which follows its initial rise. This second part of the biphasic response therefore appears to result from a direct .
Efficacy of a new navigable percutaneous disc decompression device (L'DISQ) in patients with herniated nucleus pulposus related to radicular pain.

STUDY DESIGN An institutional, prospective clinical data analysis. OBJECTIVE To evaluate the safety and efficacy of a new navigable percutaneous disc decompression device (L'DISQ) in patients with lumbar disc herniation with radicular pain. METHODS AND OUTCOME MEASURES We performed disc decompressions using L'DISQ on 27 patients with persistent disabling back and leg pain for 1 month or longer (average 6.48 months) due to a herniated lumbar intervertebral disc. Baseline data were prospectively gathered before the index procedure and at 1, 4, 12, and 24 weeks post-procedure. Data included pain intensity (visual analog scale [VAS]), measure of disability (Oswestry Disability Index [ODI] and Rolando-Morris Questionnaire [RM]), health-related quality of life (Bodily Pain Scale of Short Form-36 version 2 [SF-36 BP]), and passive straight leg raising test (SLR). RESULTS The VAS fell from 7.08±1.22 to 1.84±0.99 scores at 24 weeks post-procedure. At 24 weeks, the ODI had fallen from 41.88±10.61 to 16.66±8.55% and the RM from 11.52±3.91 to 2.68±1.97 points. The SF-36 BP dropped significant improvement from 32.89±5.83 to 49.57±4.96 scales. In the SLR test, the angular change of 24 weeks showed considerable improvement from 60.20±20.02 to 83.00±14.29 degrees. No major complication occurred, although two cases developed a disc reherniation 1 month post-procedure. CONCLUSIONS The L'DISQ device is specifically designed to remove herniated disc using a wand that can be navigated into a disc protrusion or extrusion. Following decompression, we measured clinically significant pain improvement and decreased disability for patients with both radicular and axial pain caused by protruded and extruded discs.
An intravenous toxicity study of 2-hydroxypropyf-P-cycle a useful drug so~u~~lizer, in rats and monkeys

The subacute and subchro~c intravenous (i.v.) toxicity of Z-~ydroxypropyl-~-cyc~~ext~~ (FiPCD) was ex~ined in SpragueDawley rats and cynomolgus monkeys. After either 14 or 90 days of alternate day dosing with either saline ar 200 mg/kg HPCD, no to~co~o~cally meaningful differences were observed in the following parameters: body weight. body weight gain, food consumption, hematology, clinical chemistry, organ weights, organ to brain weight ratio, organ to body weight ratio and macroscopic and microscopic histopatbology. Subsequent to these studies, an acute high-dose study was performed in cynomolgus monkeys which indicated that a single iv. dose of HPCD as bigb as 10 g/kg was not lethal.
Non destructive complex permittivity determination of glass material with planar and convex surface

A nondestructive microwave measurement setup for complex permittivity determination of glass material with planar and convex surfaces over a frequency range of 75 MHz to 6 GHz is presented. The measurement method is based on an open-ended coaxial probe technique. Two coaxial probes were constructed and their design was optimized in order to meet two contradictory requirements. On the one hand a large probe aperture is needed for sufficient measurement sensitivity at desired frequency range, on the other hand a small probe aperture is better suited for contacting non planar surfaces and avoiding air gaps. The calibration procedure of the measurement setup is explained and experimental results for planar and curved glass material are presented.
A substance P analogue reduces amino acid contents in the rat spinal cord.

In a further attempt to examine a possible neurotoxic effect of DPDT-SP on the spinal cord, we measured the levels of amino acids, glutamate, glycine, γ-aminobutyrate (GABA) and aspartate in rats which were divided into two groups after, DPDT-SP, paralysed and non-paralysed rats
A Contribuição dos Objectivos Sociais para a Conceptualização da Competência Social em Contexto Escolar

O presente estudo averiguou a contribuicao da orientacao por objectivos sociais para a conceptualizacao da competencia social em contexto escolar. Foi testado empiricamente um modelo teorico de competencia social, junto de estudantes preadolescentes, concebido pela interaccao de quatro dimensoes: objectivos sociais, competencia percebida, competencia comportamental e relacoes com os pares. O modelo de competencia social enquadra multiplas perspectivas conceptuais, atribuindo-se particular enfoque a integracao da perspectiva socio-motivacional atraves da investigacao dos objectivos sociais. Este modelo inclui as percepcoes do proprio estudante, do professor e dos pares. Uma amostra de 797 estudantes do 5o e 6o anos de escolaridade foi examinada atraves da analise de equacoes estruturais. Os resultados confirmaram as direccoes das relacoes entre as variaveis hipotetizadas pelo modelo de competencia social e evidenciaram um bom ajustamento. Especificamente, comprovou-se o aperfeicoamento do modelo com a adicao da perspectiva socio-motivacional pelo exame aos objectivos sociais na conceptualizacao da competencia social.
The mechanism of transport by mitochondrial carriers based on analysis of symmetry

The structures of mitochondrial transporters and uncoupling proteins are 3-fold pseudosymmetrical, but their substrates and coupling ions are not. Thus, deviations from symmetry are to be expected in the substrate and ion-binding sites in the central aqueous cavity. By analyzing the 3-fold pseudosymmetrical repeats from which their sequences are made, conserved asymmetric residues were found to cluster in a region of the central cavity identified previously as the common substrate-binding site. Conserved symmetrical residues required for the transport mechanism were found at the water–membrane interfaces, and they include the three PX[DE]XX[RK] motifs, which form a salt bridge network on the matrix side of the cavity when the substrate-binding site is open to the mitochondrial intermembrane space. Symmetrical residues in three [FY][DE]XX[RK] motifs are on the cytoplasmic side of the cavity and could form a salt bridge network when the substrate-binding site is accessible from the mitochondrial matrix. It is proposed that the opening and closing of the carrier may be coupled to the disruption and formation of the 2 salt bridge networks via a 3-fold rotary twist induced by substrate binding. The interaction energies of the networks allow members of the transporter family to be classified as strict exchangers or uniporters.
Research of Dual Watermarking Technology for Digital Image

Abstract Digital image watermark has been studied as object. It analyzed the typical digital watermark algorithms based on the space domain and transform domain and key researched watermarking algorithm based on discrete wavelet transform. It has designed and improved blind watermarking algorithm and color image watermarking algorithm. Finally, based on the two improved watermarking algorithm, it has designed a dual watermarking algorithm. Both are separated but related. It authenticates dual watermarking algorithm in addition to subjective visual evaluation, but also use numerical objective evaluation and quantitative analysis. Experimental results show that this dual watermarking algorithm combines with robustness and concealment.
Putting the Brake on Inflammatory Responses: the Role of Glucocorticoids

Glucocorticoids are among the most widely used agents for the treatment of inflammatory diseases. The primary mechanism of glucocorticoid action is via the glucocorticoid receptor (GR), which blocks the expression of proinflammatory cytokines and adhesion molecules. Repression of many pro‐inflammatory genes occurs by inhibition of transcription factors including nuclear factor κB (NFκB) and activator protein‐1 (AP‐1). In this article, we discuss the physiological and molecular interaction that occurs between GR and proinflammatory cytokines signaling pathways. IUBMB Life, 55: 497‐504, 2003
Hydrostatic pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up‐regulation of tumor necrosis factor‐α, inducible nitric oxide synthase, p53, c‐myc, and bax‐α, and suppression of bcl‐2

Hydrostatic pressure (HP) is thought to increase within cartilage extracellular matrix as a consequence of fluid flow inhibition. The biosynthetic response of human articular chondrocytes to HP in vitro varies with the load magnitude, load frequency, as well as duration of loading. We found that continuous cyclic HP (5 MegaPascals (MPa) for 4 h; 1 Hz frequency) induced apoptosis in human chondrocytes derived from osteoarthritic cartilage in vitro as evidenced by reduced chondrocyte viability which was independent of initial cell densities ranging from 8.1 × 104 to 1.3 × 106 cells ml−1. HP resulted in internucleosomal DNA fragmentation, activation of caspase‐3, and cleavage of poly‐ADP‐ribose polymerase (PARP). At the molecular level, induction of apoptosis by HP was characterized by up‐regulation of p53, c‐myc, and bax‐α after 4 h with concomitant down‐regulation of bcl‐2 after 2 h at 5 MPa as measured by RT‐PCR. In contrast, β‐actin expression was unchanged. Real‐time quantitative RT‐PCR confirmed a HP‐induced (5 MPa) 1.3–2.6 log‐fold decrease in bcl‐2 mRNA copy number after 2 and 4 h, respectively, and a significant increase (1.9–2.5 log‐fold) in tumor necrosis factor‐α (TNF‐α) and inducible nitric oxide synthase (iNOS) mRNA copy number after 2 and 4 h, respectively. The up‐regulation of p53 and c‐myc, and the down‐regulation of bcl‐2 caused by HP were confirmed at the protein level by Western blotting. These results indicated that HP is a strong inducer of apoptosis in osteoarthritic human chondrocytes in vitro. J. Cell. Biochem. 87: 266–278, 2002. © 2002 Wiley‐Liss, Inc.
Evaluation of enzyme immunoassay for the detection of pathogenic Yersinia enterocolitica and Yersinia pseudotuberculosis strains

To determine the virulence plasmid-harboring strains of Yersinia enterocolitica, we prepared antiserum against plasmid-encoded proteins of Y. enterocolitica serotype O3 and carried out an enzyme immunoassay (EIA) against temperature-inducible released proteins. This serum reacted with proteins released from not only a Y. enterocolitica serotype O3 strain but also Y. enterocolitica serotype O5:27, O8, and O9 and Y. pseudotuberculosis serotype 1b, 2a, 2b, 2c, 3, 4a, 4b, 5a, 5b, 6, 7, and 8 strains, which all harbored plasmids. Plasmid-cured Y. enterocolitica and Y. pseudotuberculosis strains did not react in the EIA, nor did nonpathogenic Y. enterocolitica strains or Y. frederiksenii, Y. intermedia, and Y. kristensenii strains. These observations demonstrated that this EIA was useful for determining whether the isolated Yersinia strains were pathogenic or not.