Miracle-dz/UniFAR-FTUs huggingface dataset:
Oncologic approach to the treatment of cancerassociated pain

Pain is one of the more common symptoms of malignant disease. It is an extremely unpleasant and frightening symptom that as a rule manifests in more advanced stages of the disease. Due to the nature and spread of tumor disease (incurability), the pain experienced by oncologic patients is frequently of a chronic type. In such conditions, there is no doubt that pain adversely aff ects the patient quality of life. Alongside physical pain, patients suff ering from a malignant disease can also experience mental (emotional) pain. Consequently, the pain felt by oncologic patients is not only a physical experience but a manifestation of a variety of psychological, social and spiritual elements. Th at is why the concept of ‘total pain’ is used. When treating pain, the focus should not be only on the pain itself (physical pain) but also on the person as a whole. Since all the components of pain must be attended, treating oncologic patients very oft en requires a multimodal and multidisciplinary approach. Pharmacological treatment of pain, which includes the use of non-opioid analgesics, opioids and other drugs, is the basis of treating pain (1-6). Radiotherapy also has its place in the treatment of pain, for example, pain caused by bone metastases and pain (headaches) associated with primary and metastatic brain tumors. Th is paper aims to briefl y outline the role of radiotherapy in treating cancer pain. Since such clinical situations most oft en involve patients suff ering from incurable diseases, palliative radiotherapy approach is adopted with the aim of alleviating discomfort (pain) and maintaining or improving the quality of life (2, 7-9). Oncologic approach to the treatment of cancerassociated pain
Finite State Machine for the Social Engineering Attack Detection Model: SEADM

Based on: “Underlying Finite State Machine for the Social Engineering Attack Detection Model”, by F. Mouton, A. Nottingham, L. Leenen and H.S. Venter which appeared in the Proceedings of Information Security South African (ISSA) 2017, Johannesburg, 16 & 17 August 2017.
EAR‐ACUPUNCTURE RELAXATION THERAPY IN ALCOHOLICS

Ninety‐five out of 190 alcoholics treated in 1977 by ear‐acupuncture relaxation therapy were selected for a follow‐up survey. Sixty‐two replied to our letters and were interviewed (by C.F.). Sixteen (25.8%) said that they had maintained total sobriety for over 12 months, while 54 (87%) said that their life‐style, drinking pattern and physical and mental health had improved. Thus, a significant percentage had been helped to improved health and to a changed way of life.
A Review of Studies on Ethnic Differences of Brain-Derived Neurotrophic Factor Genes in Patients with Post-Traumatic Stress Disorder

In the regulation of human nervous system, cognitive function and other genes, epigenetics changes the expression of genes after being influenced by the external environment. DNA methylation levels are also different in different ethnic groups, and a large number of studies have shown that post-traumatic stress disorder (PTSD) has a certain genetic predisposition. Through the national differences of PTSD brain-derived neurotrophic factor genes, it not only provides new research directions for the pathogenesis and treatment of 5-HT-related mental diseases, but also provides information and new genetic indicators for forensic personal identification, paternity testing and assessment of mental status. A review studies on the national differences of brain-derived neurotrophic factor genes in patients with post-traumatic stress disorder.
MR/GR Signaling in the Brain during the Stress Response

This contribution is about mineralocorticoid receptors (MRs) in their capacity as mediators of glucocorticoid action in the brain. This paradox has evolved because MRs are promiscuous and bind with high-affinity cortisol and corticosterone as well as aldosterone, deoxycorticosterone, and progesterone. The MRs “see,” however, predominantly glucocorticoids, because of their 100–1000-fold excess over aldosterone; bioavailability is further enhanced because of local regeneration of glucocorticoids by 11 β OH-steroid dehydrogenase (HSD-1). In contrast to these glucocorticoid-preferring MR, the evolutionary later appearance of aldosterone-selective MR in epithelial cells depends on co-localization with the oxidase 11 β -hydroxysteroid-dehydrogenase type 2 (HSD-2) in a few hundred neurons in the nucleus tractus solitarii (NTS), which innervate frontal brain regions to regulate cognitive, emotional, and motivational aspects of salt appetite. The glucocorticoid-MRs and classical glucocorticoid receptors (GRs) mediate in a complementary manner the glucocorticoid coordination of circadian events and mediate the regulation of stress coping and adaptation. If an individual is exposed to a threat, MRs are crucial for the selection of a particular coping style, which is via GR activation subsequently stored in the memory for future use. Our contribution is concluded with the notion that an imbalance in MR- and GR-mediated actions increases susceptibility to stress-related disorders.
Emerging Antibiotic Resistance to Bacterial Isolates from Human Urinary Tract Infections in Grenada

A urinary tract infection (UTI) in humans is one of the most common ailments in developing countries. The treatment of UTI is becoming difficult because of the increasing drug resistance against the common bacteria associated with UTI. This research aimed to determine the bacteria, and their antimicrobial drug resistance, associated with UTI in the Grenada population. A retrospective study of data (2015 through 2017) from the microbiology laboratory of the Grenada General Hospital was analyzed. Bacteria were isolated from 1289 (33.3%) urine cultures of 3867 UTI suspected urine samples. Both Gram-positive (Staphylococcus aureus 5.0%; Enterococci group D 43.2%) and Gram-negative bacteria (Escherichia coli 51%; Klebsiella pneumoniae20.0%; Proteus mirabilis 10.0%; Acinetobacter spp. 20.0%) were isolated. Bacterial isolates were tested for their resistance to nine antibacterial drugs (ampicillin, gentamicin, norfloxacin, cefuroxime, ceftazidime, Bactrim, imipenem, augmentin, and ciprofloxacin). Gram-negative bacteria showed higher antimicrobial drug resistance.
Emergent measures and patterns of recovery during acute exacerbations of Chronic Obstructive Pulmonary Disease.

As exacerbacoes agudas da doenca pulmonar obstrutiva cronica (EADPOC) sao eventos frequentes e onerosos. Contudo, o conhecimento acerca da sua avaliacao e curso de evolucao e limitado. Este trabalho de investigacao teve como objetivo compreender a avaliacao e os padroes de recuperacao das EADPOC geridas em contexto de ambulatorio. Especificamente, pretendeu-se: i) aprofundar oconhecimento acerca das medidas de avaliacao mais utilizadas na avaliacao dedoentes com EADPOC e ii) explorar os padroes de recuperacao durante as EADPOC utilizando diferentes medidas de avaliacao. Foram realizados seis estudos. A Revisao Sistematica e os Estudos empiricos I e II responderam ao primeiro objetivo especifico deste trabalho de investigacao, sintetizando e explorando a fiabilidade, validade, capacidade de resposta e interpretabilidade de medidas de avaliacao comummente utilizadas e de facil acesso para a avaliacao de doentes com EADPOC em contexto de ambulatorio. Os resultados revelaram que apesar de existirem poucas medidas de avaliacao com as suas propriedades metricas adequadamente estudadas, os seus valores de interpretabilidade parecem semelhantes aos estabelecidos em fases estaveis da DPOC. O segundo objetivo especifico deste trabalho de investigacao foi alcancado atraves de tres Estudos empiricos (Estudos III, IV e V) que demonstraram que a recuperacao de uma EADPOC e influenciada pelas caracteristicas dos doentes no momento inicial da exacerbacao. Estes Estudos mostraram ainda que as medidas reportadas pelos doentes e as medidas clinicas diferem nos seus padroes e tempos de recuperacao durante as EADPOC. Os resultados deste trabalho de investigacao constituem nova evidencia acerca das medidas de avaliacao e dos momentos mais adequados para avaliar, monitorizar e interpretar alteracoes no curso de EADPOC. E necessario realizar mais investigacao com metodologias padrao, amostras maiores e desenhos de estudo longitudinais com avaliacoes pre e pos exacerbacao de forma a consolidar estes resultados preliminares e aumentar o conhecimento acerca do curso de evolucao das EADPOC geridas em contexto de ambulatorio.Palavras-chave: DPOC, EXACERBACOES, MEDIDAS DE RESULTADOS, PROPRIEDADES DE MEDIDA, RECUPERACAO, EVOLUCAO.
Multi-clustered Energy Level based Efficient Routing Protocol in Wireless Sensor Network

Wireless sensor network (WSN) is an active research domain as well as innovative concepts are introduced regularly. Due to onetime battery back, the energy efficiency of WSN has become critical issue, because battery recharge or replacement is not possible after deployment of the network and they work until battery dead. Many recent applications of Internet of things (IoT) are extensively applying sensor based applications. In this paper, an innovative concept of energy level calculation of sensor node is introduced for cluster head selection to improve network lifetime. In this paper, MELBER a (multi-clustered energy level based efficient routing) protocol is proposed for WSN. The simulation result presents significant improvement of energy efficiency of WSN.
Bitcoin technical trading with artificial neural network

This paper explores Bitcoin intraday technical trading based on artificial neural networks for the return prediction. In particular, our deep learning method successfully discovers trading signals through a seven layered neural network structure for given input data of technical indicators, which are calculated by the past time-series data over every 15 minutes. Under feasible settings of execution costs, the numerical experiments demonstrate that our approach significantly improves the performance of a buy-and-hold strategy. Especially, our model performs well for a challenging period from December 2017 to January 2018, during which Bitcoin suffers from substantial minus returns. Furthermore, various sensitivity analysis is implemented for the change of the number of layers, activation functions, input data and output classification to confirm the robustness of our approach.
Algorithms for Embedded Memory Binding in FPGAS

Recent advancements in semiconductor fabrication technology have enabled fieldprogrammable gate arrays (FPGAs) with hundreds of embedded memories. Usually, these embedded memories can be configured to work with different widths of address and data buses. In some FPGAs there is also a variety of different types of embedded memories with different capacities and configuration sets. As a consequence, it is becoming cumbersome to bind the data memory of an algorithm to these embedded memories manually. A computer-aided design tool that automates the process of binding embedded memories can save the engineering time for a design, as well as explore different alternatives to bind the data memory with the use of less embedded memories and less amount of peripheral hardware in terms of logic cells of the FPGA. In this thesis, we first motivate the need for an algorithmic solution to the memory binding problem in FPGAs and explain the design trade-offs. Then we present an exact solution for the problem using a branching method to search the solution space exhaustively. However, due to the large solution space and the plenitude of choices in each step of the algorithm, the runtime of the algorithm is far from being acceptable for realistic problems. To manage the runtime, we have developed a fast heuristic approach. Our experimental results show that the heuristic method can achieve a suboptimal solution, which for small problem instances is shown to be close to the optimal in acceptable runtime. Moreover, when compared to manual solutions, besides substantially improving the implementation time, the heuristic can often enable a more efficient usage of the FPGA logic resources and embedded memories.
The Multimodal Production of Common Ground Understandings in Intercultural Flight Training

Effective collaboration requires the creation and maintenance of common ground understandings (Clark, 1992). This is an especially interesting problem in the case of intercultural collaboration, where communicative conventions may not be shared. However, intercultural collaboration often takes place in professionally relevant material settings and among people who share professional competence. This paper discusses ethnographic field data which we collected at the Boeing/Alteon training center in Renton, WA, where Japanese airline pilots received flight training from American flight instructors. We attempt to clarify how the pilots and the instructors effectively use multimodal representations to achieve intercultural common ground understandings.
Strabismus in geriatric patients: etiology and clinical features

Introduction: As life expectancy is continuously increasing, health issues, such as strabismus that has a functional and psychosocial impact on the quality of life, have gained more importance and require a solution. In the present study, we aimed to describe and determine the strabismus etiology and clinical features in patients aged ≥65 years who were examined in a strabismus clinic. Materials and Method: We retrospectively examined the data of patients aged ≥65 years who were admitted to the strabismus clinic between July 2018 and July 2019. The findings of the ophthalmological and orthoptic examination as well as the strabismus etiology, intervention required, and chief complaints were all recorded. Results: We extracted the medical records of 40 patients (16 female and 24 male) aged ≥65 years who were examined in the strabismus clinic. The chief complaint was diplopia in 30 (75%) patients, followed by ocular deviation in 10 (25%) patients. The deviation was horizontal in 26 (65%) patients. The most common etiology was thyroid eye disease (6 patients; 15%), followed by diabetes (5 patients, 12.5%), hypertension (5 patients, 12.5%), trauma (3 patients, 7.5%), cerebrovascular event (3 patients, 7.5%), intracranial mass (3 patients, 7.5%), and secondary deviation (3 patients, 7.5%). Moreover, 11 (27.5%) patients underwent surgery, whereas 17 (42.5%) patients received nonsurgical treatment; 14 (35%) patients did not re-visit the strabismus clinic. Conclusion: Strabismus can be seen in elderly individuals. The underlying etiology, such as trauma and cerebrovascular events, may be life threatening and requires prompt diagnosis and treatment.
Kinect Sensor Based Gesture Recognition for Surveillance Application

Hand gesture recognition has been granted as one of the emerging fields in research today providing a natural way of communication between man and a machine. Gestures are some forms of body motions which a person expresses when doing a work or giving a reply. Human body tracking is a well studied topic in todays era of Human Computer Interaction and it can be formed by the virtue of human skeleton structures. These skeleton structures have been detected successfully due to the smart progress of some devices, used to measure depth. Human body movements have been viewed using these depth sensors which can provide sufficient accuracy while tracking full body in real time mode with low cost. In reality action and reaction activities are hardly periodic in a multi person perspective situation. Also recognizing their complex a-periodic gestures are highly challenging for detection in surveillance system.
Modern oral medications to prevent venous thromboembolism – critical review of evidence base in terms of a risk/benefit ratio

Modern oral medications used to prevent venous thromboembolism (VTE) have gained widespread use with major orthopaedic and trauma procedures. There are no accurate multicenter data on the frequency of usage of different prophylactic medications in our country but discussions of the colleagues at specialized web forums make us suspect that factor Xa and dabigatran etexilate inhibitors are in the top three next to low molecular weight heparins. Marketing and promotion strategies of pharmaceutical companies are likely to be of immense importance in that with the contribution of clinical research studies for pharmaceutical drugs. However, preferences of European and American orthopaedic surgeons for the choice of drugs are completely different from those of Russian surgeons. Vitamin K antagonists, acetylsalicylic acid, low molecular weight heparins are commonly used for antithrombotic therapy abroad. Different approaches of Russian and foreign orthopaedic surgeons to the choice of drugs can be explained by a different use of a high-quality evidence base. In our opinion, a collision component can be involved in the endpoints of clinical trials that will be discussed in the present critical review.
Relationship between fibrinogen -to- albumin ratio and angiographic no-reflow in elderly patients with st-elevation myocardial infarction treated with primary percutaneous coronary intervention

244 ILERI YAŞTA ST YÜKSELMELI MIYOKARD ENFARKTÜSÜ ILE BAŞVURAN VE PRIMER PERKÜTAN KORONER GIRIŞIM YAPILAN HASTALARDA ANJIYOGRAFIK NO-REFLOW ILE FIBRINOJEN / ALBÜMIN ORANI ARASINDAKI ILIŞK
Unemployment and young people's health: In reply

In reply: The leading conditions reported from psychological autopsies of young suicides have been "mood and affective disorders", "substance use disorders", and "conduct and antisocial disorders", in proportions as high as 95% of cases. As most psychological autopsy studies to date have been conducted without control groups (ie, respondents who are friends or relatives of living subjects broadly similar to those who have died by suicide), it is difficult to assess the extent of differences in the prevalence of "mental illness" in young suicide victims when compared with similar, living populations. Of the few controlled psychological autopsy studies, one found an odds ratio for suicide of 12 when a "mood disorder" was reported, 1 while another study found an odds ratio of 27 when major depression was reported to be present.2 While these odds ratios and proportions appear extremely high, they should be put into some perspective: there is scant evidence in the literature indicating the extent of recall bias in such studies (where the outcome for cases tends more often than for controls to be attributed retrospectively to conditions or exposures that were not present or relevant). Suicide is particularly problematic as participants in psychological autopsies are grieving relatives and friends, who may be suffering resulting psychological impairment themselves, and who are trying desperately to fmd reasons, or reason, behind the suicide. More generally, a distinction between the terms "mental illness", "psychiatric illness" and "a psychiatric diagnosis" should be made. There is a grey area between psychological disturbance as a normal response to misfortune or disagreeable circumstance, and mental or psychiatric illness. The main tool for making a "psychiatric
Novel Design and Implementation of MIMO Antenna for LTE Application

The quest for achieving high bandwidth connectivity that renders a complete wireless system ideal for video-intensive applications at very low power consumption using multiple inputs/multiple outputs (MIMO) dual-band combo chip with high-speed is ever-growing. A newly designed structure of the MIMO antenna four ports is implemented for efficient bandwidth broadening. The bandwidth and Sparameters of the antenna are simulated and determined. The dual-band MIMO micro-strip patch antenna comprised of four ports where the ground plane is extruded on a substrate having area 125x128 mm2 and thickness 1.6 mm. The antenna is fabricated on an inexpensive FR4 with the dielectric constant of 4.5, loss tangent ~0.019 and patch thickness of 0.035 mm. The MIMO antenna with dimension 53.5x38. 25 mm2 operates at 1.8 and 2.6 GHz. The proposed antenna is found to achieve good pattern diversity, low correlation coefficient, high gain, excellent directivity, and quite reasonable bandwidth in the abovementioned range, highly suitable for LTE bands application with 10 dB return loss. The CST microwave studio program is used for the simulation, and real experimental measurements are made using Agilent Technologies E5071B VNA and the equipment inside the anechoic chamber. Measurements on the prototype antenna are carried out, and characteristic evaluations are performed for comparison. The admirable features of the results suggest that our systematic approach may constitute a basis for the design and implementation of MIMO antenna for diverse LTE applications.
Cost-benefit analysis of VKA versus NOAC treatment in German patients with atrial fibrillation utilizing patient self-testing

Background: Clinical complications of long-term anticoagulation in patients with atrial fibrillation cause significant morbidity and have a substantial economic impact on the healthcare system. Objective: To assess the cost-benefit by implementing patient self-testing (PST) in German patients anticoagulated with vitamin K antagonists (VKA) compared to treatment with the new oral anticoagulant drugs (NOAC) apixaban, dabigatran, edoxaban, and rivaroxaban. Methods: A deterministic decision-analytic model was developed simulating the number of major bleedings, ischemic strokes, and hemorrhagic strokes and their associated costs by utilizing PST compared to those of treatment with NOAC. Data on the rates of these adverse events in both groups during the 1st year of treatment was taken from the NOAC approval studies. Direct costs were evaluated from the perspective of the Statutory Health Insurance (SHI) considering the use of resources directly related to PST testing and costs incurred by hospital treatment of the adverse events. Univariate sensitivity analysis was performed to examine the extent to which our calculations were affected by varying the parameters considered in our model within plausible extremes. To capture the interactions between multiple inputs, we also provided a probabilistic sensitivity analysis (PSA). Results: When achieving an average time in therapeutic range (TTR) of 78%, implementing PST in VKA patients reduces cost per patient compared to NOAC treatment between €603.38 [USD 681.52] (edoxaban) and €762.64 [USD 861.40] (rivaroxaban) during the 1-year observation period. In line with the TTR increase, the initially higher number of adverse events per VKA patient compared to NOAC-treated patients in the approval studies becomes largely aligned; the difference in associated hospital costs per patient in the NOAC groups is then only €1.03 [USD 1.16] (in favor of dabigatran), €23.41 [USD 26.44] (in favor of apixaban), €0.53 [USD 0.60] (in favor of edoxaban) and €52.62 [USD 59.43] (in favor of VKA anticoagulation in the rivaroxaban group). In PSA, implementation of self-management results on average in a cost saving between €619.20 [USD 699.39] and €785.24 [USD 886.93] per VKA patient in favor of the SHI. Under all reasonable assumptions, PST remains constantly less expensive irrespective of which NOAC is administered. Conclusion: Implementing PST in German VKA patients may significantly reduce SHI expenditures compared to utilizing NOAC.