Miracle-dz/UniFAR-FTUs huggingface dataset:
Light core and intelligent edge for a flexible, thin-layered, and cost-effective optical transport network

We present a new optics-based transport architecture that emulates fast switching in the network core via emerging fast tunable lasers at the network edge, and bypasses the need for fast optical switching and buffering. The new architecture is capable of handling both asynchronous and synchronous traffic, for dealing with various bandwidth granularities and responding to dynamic changes in end-to-end traffic demands. The architecture also reduces the amount of layering in the transport network by eliminating packet and TDM switching, keeps the network core light (lightweight and transparent), and pushes intelligence to the network edge. We discuss technical challenges that arise in the new architecture and describe possible approaches to address them.
Enhancing the fatty acid profile of milk through forage‐based rations, with nutrition modeling of diet outcomes

Abstract Consumer demand for milk and meat from grass‐fed cattle is growing, driven mostly by perceived health benefits and concerns about animal welfare. In a U. S. ‐wide study of 1,163 milk samples collected over 3 years, we quantified the fatty acid profile in milk from cows fed a nearly 100% forage‐based diet (grassmilk) and compared it to profiles from a similar nationwide study of milk from cows under conventional and organic management. We also explored how much the observed differences might help reverse the large changes in fatty acid intakes that have occurred in the United States over the last century. Key features of the fatty acid profile of milk fat include its omega‐6/omega‐3 ratio (lower is desirable), and amounts of total omega‐3, conjugated linoleic acid, and long‐chain omega‐3 polyunsaturated fatty acids. For each, we find that grassmilk is markedly different than both organic and conventional milk. The omega‐6/omega‐3 ratios were, respectively, 0.95, 2.28, and 5.77 in grassmilk, organic, and conventional milk; total omega‐3 levels were 0.049, 0.032, and 0.020 g/100 g milk; total conjugated linoleic acid levels were 0.043, 0.023, and 0.019 g/100 g milk; and eicosapentaenoic acid levels were 0.0036, 0.0033, and 0.0025 g/100 g milk. Because of often high per‐capita dairy consumption relative to most other sources of omega‐3 fatty acids and conjugated linoleic acid, these differences in grassmilk can help restore a historical balance of fatty acids and potentially reduce the risk of cardiovascular and other metabolic diseases. Although oily fish have superior concentrations of long‐chain omega‐3 fatty acids, most fish have low levels of α‐linolenic acid (the major omega‐3), and an omega‐6/omega‐3 ratio near 7. Moreover, fish is not consumed regularly, or at all, by ~70% of the U. S. population.
Snippet Matching for Click-Tracking Blocking User Privacy for Search Engines

This dissertation proposes a solution to the privacy issues regarding user clicktracking by search engines by a means of a URL resolution service. The proposed solution would leverage the search result snippet data to be used for look up of the respective search result URL in a user-collected snippet-URL repository. In order to examine the viability of the proposed solution, the dissertation investigates whether search result snippets can be used to successfully infer search result URLs. A search result dataset is collected from the Google search engine and a snippet matching algorithm is developed. An examination of the search snippet dataset indicates that snippets consist of a highly diverse content, making them easily identifiable. The error rate evaluation of snippet matching yields an error rate of 3.48%, indicating that search result snippets can be used for URL resolution with great accuracy, provided a priori knowledge of the snippet-URL mapping exists. Additional investigation into snippet stability and the snippet matching algorithm’s resilience to modification of input further support the viability of a click-tracking blocking system that employs snippet matching for URL resolution as snippets are mostly stable over time and the matching process is robust to input change.
Nonconventional metasurfaces: from non-Hermitian coupling, quantum interactions, to skin cloak

Abstract Metasurfaces are optically thin layers of subwavelength resonators that locally tailor the electromagnetic response at the nanoscale. Our metasurface research aims at developing novel designs and applications of metasurfaces that go beyond the classical regimes. In contrast to conventional phase gradient metasurfaces where each meta-atom responds individually, we are interested in developing metasurfaces where neighboring meta-atoms are strongly coupled. By engineering a non-Hermitian coupling between the meta-atoms, new degrees of freedom are introduced and novel functionalities can be achieved. We are also interested in combining classical metasurface with quantum emitters, which may offer opportunities for on-chip quantum technologies. Additionally, we have been designing metasurfaces to realize exciting phenomena and applications, such as ultrathin metasurface cloak and strong photonic spin-Hall effect. In this paper, we review our research efforts in optical metasurfaces in the past few years, which ranges from conventional to novel type of metasurface and from classical to quantum regime.
Joint Altitude, Beamwidth, Location, and Bandwidth Optimization for UAV-Enabled Communications

This letter investigates an uplink power control problem for unmanned aerial vehicles (UAVs)-assisted wireless communications. We jointly optimize the UAV’s flying altitude, antenna beamwidth, UAV’s location, and ground terminals’ allocated bandwidth, and transmit power to minimize the sum uplink power subject to the minimal rate demand. An iterative algorithm is proposed with low complexity to obtain a suboptimal solution. Numerical results show that the proposed algorithm can achieve good performance in terms of uplink sum power saving.
Large‐scale genetic panmixia in the blue shark (Prionace glauca): A single worldwide population, or a genetic lag‐time effect of the “grey zone” of differentiation?

The blue shark Prionace glauca, among the most common and widely studied pelagic sharks, is a top predator, exhibiting the widest distribution range. However, little is known about its population structure and spatial dynamics. With an estimated removal of 10–20 million individuals per year by fisheries, the species is classified as “Near Threatened” by International Union for Conservation of Nature. We lack the knowledge to forecast the long‐term consequences of such a huge removal on this top predator itself and on its trophic network. The genetic analysis of more than 200 samples collected at broad scale (from Mediterranean Sea, North Atlantic and Pacific Oceans) using mtDNA and nine microsatellite markers allowed to detect signatures of genetic bottlenecks but a nearly complete genetic homogeneity across the entire studied range. This apparent panmixia could be explained by a genetic lag‐time effect illustrated by simulations of demographic changes that were not detectable through standard genetic analysis before a long transitional phase here introduced as the “population grey zone. ” The results presented here can thus encompass distinct explanatory scenarios spanning from a single demographic population to several independent populations. This limitation prevents the genetic‐based delineation of stocks and thus the ability to anticipate the consequences of severe depletions at all scales. More information is required for the conservation of population(s) and management of stocks, which may be provided by large‐scale sampling not only of individuals worldwide, but also of loci genomewide.
Standards for testing and clinical validation of seizure detection devices

To increase the quality of studies on seizure detection devices, we propose standards for testing and clinical validation of such devices. We identified 4 key features that are important for studies on seizure detection devices: subjects, recordings, data analysis and alarms, and reference standard. For each of these features, we list the specific aspects that need to be addressed in the studies, and depending on these, studies are classified into 5 phases (0‐4). We propose a set of outcome measures that need to be reported, and we propose standards for reporting the results. These standards will help in designing and reporting studies on seizure detection devices, they will give readers clear information on the level of evidence provided by the studies, and they will help regulatory bodies in assessing the quality of the validation studies. These standards are flexible, allowing classification of the studies into one of the 5 phases. We propose actions that can facilitate development of novel methods and devices.
Achieving Data Dissemination with Security using FIWARE and Intel Software Guard Extensions (SGX)

The Internet of Things (IoT) field has gained much attention from industry and academia, being the main subject for numerous research and development projects. Frequently, the dense amount of generated data from IoT applications is sent to a cloud service, that is responsible for processing and storage. Many of these applications demand security and privacy for their data because of their sensitive nature. This is specially true when such data must be processed in entities hosted in public clouds, where the environment in which applications run may not be trusted. Some concerns are then raised since it is not trivial to provide the needed protection for these sensitive data. We present a solution that considers the security components of FIWARE and the Intel SGX capabilities. FIWARE is a platform created to support the development of Smart Applications, including IoT systems, and SGX is the Intel solution for Trusted Execution Environment (TEE). We propose a new component for key management that, together with other FIWARE components, can be used to provide privacy, confidentiality, and integrity guarantees for IoT data. A case study illustrates how this proposed solution can be employed in a realistic scenario, which allows the dissemination of sensitive data through public clouds without risking privacy issues. The results of the experiments provide evidence that our approach does not harm scalability or availability of the system. In addition, it presents acceptable memory costs when considering the benefit of the privacy guarantees achieved.
Short-Term and Long-Term Solutions for Secure Verification of Aircraft- Reported ADS-B Location in Air Traffic Networks

Automatic dependent surveillance-broadcast (ADSB) is the foundation of next generation air traffic management systems. The precision granted by ADS-B will allow for the network to support the huge growth in air traffic in the coming decades and assist both air traffic controllers and pilots in improving safety in flight. However, the ADS-B protocol has serious security vulnerabilities. Coupled with the importance of ADS-B in the air transportation system, these security issues make ADS-B an appealing target for attack by adversaries. This paper dismisses the need for encryption and focuses security strategies on location verification. Multilateration is combined with data fusion and location tracking for effective and undemanding short-term and long-term location verification. By taking input from air traffic controllers, a secondary location tracking systems allows for a backup record of controlled aircraft that can easily be referred to in emergencies.
Is Fibromyalgia Risk Higher Among Male and Young Inflammatory Bowel Disease Patients? Evidence from a Taiwan Cohort of One Million.

BACKGROUND Prior literatures have shown inflammatory bowel disease (IBD) could increase fibromyalgia (FM) risk. However, studies about gender and age distributions of FM risk among patients with IBD are rare. With large study samples, this study aimed to evaluate the FM risk among IBD patients with different gender and different age. OBJECTIVE We aim to estimate the FM risk among male and younger IBD patients with a large patient sample. STUDY DESIGN A retrospective cohort study was arranged in this research. SETTING The data used in this research were selected from the Taiwan National Health Insurance Research Database (NHIRD). METHODS From the Taiwan NHIRD, we selected 4,510 patients with IBD and 18,040 randomly gender- and age-matched patients without a history of IBD from the beginning of 2000 to the end of 2005 to analyze the development of FM over a 12-year follow-up period (2000-2011). The Cox regression model was used to assess the effects of IBD on the risk of FM by adjusting for gender, age, and comorbidities, including hypertension, diabetes, hyperlipidemia, depression, anxiety, and sleep disorder. RESULTS After adjusting suitable covariates, the IBD patients had a greater FM risk (adjusted hazard ratio [aHR] 1.70, 95% confidence interval [CI] 1.59-1.83) than the controls. Male IBD patients had a higher FM risk than female IBD patients did (aHR 2.00, 95% CI 1.79-2.23 and aHR 1.52, 95% CI 1.38-1.67, respectively). The greatest age-specific FM risk occurred in the youngest IBD subgroup (= 39 years old) (aHR 1.92, 95% CI 1.68-2.19). LIMITATIONS The information about personal behaviors was unobtainable in the Taiwan NHIRD. Other risk factors for cardiovascular disease that might augment FM cannot be excluded entirely in this study. CONCLUSION IBD is disclosed to be correlated with an enhanced risk to develop FM, particularly in male and younger IBD patients. For preventing FM, it is necessary to pay more attention to the management of the IBD patients. Future researches are needed to further confirm the findings in this study. KEY WORDS Inflammation, inflammatory bowel disease, fibromyalgia, Taiwan National Health Insurance Research Database.
Integrated Stress Responses to Bacterial Pathogenesis Patterns

Activation of an appropriate innate immune response to bacterial infection is critical to limit microbial spread and generate cytokines and chemokines to instruct appropriate adaptive immune responses. Recognition of bacteria or bacterial products by pattern recognition molecules is crucial to initiate this response. However, it is increasingly clear that the context in which this recognition occurs can dictate the quality of the response and determine the outcome of an infection. The cross talk established between host and pathogen results in profound alterations on cellular homeostasis triggering specific cellular stress responses. In particular, the highly conserved integrated stress response (ISR) has been shown to shape the host response to bacterial pathogens by sensing cellular insults resulting from infection and modulating transcription of key genes, translation of new proteins and cell autonomous antimicrobial mechanisms such as autophagy. Here, we review the growing body of evidence demonstrating a role for the ISR as an integral part of the innate immune response to bacterial pathogens.
Altered Immunity in Endometriosis: What Came First?

ABSTRACT Background: This study was conducted to summarize current knowledge of the changes within the immune system, from action of macrophages, lymphocytes and NK cells to biological effects of their products. Endometriosis is a complex gynecological disorder defined as a presence of endometrial tissue outside the uterus affecting over 5 million reproductive-aged women in the U.S. alone. Result: In recent years, the potential role of the immune system in the development of endometriosis has increasingly gained attention. Data summarized in our study showed that the most relevant immunocytes are macrophages residing inside the peritoneal cavity and the ratios of Th1 to Th2 cells. Another crucial immunological parameter is the balance in production of cytokines and chemoatractants. Conclusions: This review confirms that despite decades of intensive research, the involvement of the immune system remains elusive, as we can recognize the changes, but still do not understand if these changes represent the results of endometriosis or if they are contributing factors. Based on these findings, we also discuss new treatment possibilities.
Bone substitute made from a Brazilian oyster shell functions as a fast stimulator for bone-forming cells in an animal model

Despite their demonstrated biocompatibility and osteogenic properties, oyster shells have been reported as a potential alternative to other commonly used materials for bone substitution. This study evaluated whether an experimental bone substitute (EBS) made from a typical oyster shell of Northeastern Brazil (Crassostrea rhizophora) has effects on bone development using an animal model. Oysters were collected from a biologically assisted vivarium, and their inner layer was used for preparing an EBS. Chemical and surface characterization of EBS was performed using Individually Coupled Plasma Optical Emission Spectrometry (ICP-OES) and Scanning Electron Microscope (SEM), respectively. Seventy-two rats were randomly assigned to groups according to the treatment of bone defects created in the submandibular area: Negative Control (-C), Positive Control (+C; Bio-Oss®) and EBS. Euthanasia occurred at 7, 21, 42 and 56 days postoperatively. The bone pieces were stained with hematoxylin and eosin (H&E). The formation of bone tissue was evaluated histologically and histomorphometrically. Data were analyzed through the Kruskal-Wallis test and ANOVA considering a significant level of 5%. The main element found in EBS was calcium (71.68%), and it presented heterogeneity in the particle size and a porosity aspect at SEM analysis. Histological results revealed the absence of inflammatory cells in all groups, being that EBS presented the most accelerated process of bone formation with a statistically significant difference between this group and the +C and -C groups in the 21-day time-point (p < 0.05). After 21 days, the bone formation process was similar between all groups (p > 0.05), showing an immature lamellar bone pattern after 56 days of experimentation (p > 0.05). Within the limitations of this study, it was possible to conclude that EBS presented good biocompatibility and promoted fast stimulation for bone-forming cells in an animal model.
Significant Improvement of Acute Complete Spinal Cord Injury Patients Diagnosed by a Combined Criteria Implanted with NeuroRegen Scaffolds and Mesenchymal Stem Cells

Stem cells and biomaterials transplantation hold a promising treatment for functional recovery in spinal cord injury (SCI) animal models. However, the functional recovery of complete SCI patients was still a huge challenge in clinic. Additionally, there is no clinical standard procedure available to diagnose precisely an acute patient as complete SCI. Here, two acute SCI patients, with injury at thoracic 11 (T11) and cervical 4 (C4) level respectively, were judged as complete injury by a stricter method combined with American Spinal Injury Association (ASIA) Impairment Scale, magnetic resonance imaging (MRI) and nerve electrophysiology. Collagen scaffolds, named NeuroRegen scaffolds, with human umbilical cord mesenchymal stem cells (MSCs) were transplanted into the injury site. During 1 year follow up, no obvious adverse symptoms related to the functional scaffolds implantation were found after treatment. The recovery of the sensory and motor functions was observed in the two patients. The sensory level expanded below the injury level, and the patients regained the sense function in bowel and bladder. The thoracic SCI patient could walk voluntary with the hip under the help of brace. The cervical SCI patient could raise his lower legs against the gravity in the wheelchair and shake his toes under control. The injury status of the two patients was improved from ASIA A complete injury to ASIA C incomplete injury. Furthermore, the improvement of sensory and motor functions was accompanied with the recovery of the interrupted neural conduction. These results showed that the supraspinal control of movements below the injury was regained by functional scaffolds implantation in the two patients who were judged as the complete injury with combined criteria, it suggested that functional scaffolds transplantation could serve as an effective treatment for acute complete SCI patients.
Sleep Tracking and Exercise in Patients With Type 2 Diabetes Mellitus (Step-D): Pilot Study to Determine Correlations Between Fitbit Data and Patient-Reported Outcomes

Background Few studies assessing the correlation between patient-reported outcomes and patient-generated health data from wearable devices exist. Objective The aim of this study was to determine the direction and magnitude of associations between patient-generated health data (from the Fitbit Charge HR) and patient-reported outcomes for sleep patterns and physical activity in patients with type 2 diabetes mellitus (T2DM). Methods This was a pilot study conducted with adults diagnosed with T2DM (n=86). All participants wore a Fitbit Charge HR for 14 consecutive days and completed internet-based surveys at 3 time points: day 1, day 7, and day 14. Patient-generated health data included minutes asleep and number of steps taken. Questionnaires assessed the number of days of exercise and nights of sleep problems per week. Means and SDs were calculated for all data, and Pearson correlations were used to examine associations between patient-reported outcomes and patient-generated health data. All respondents provided informed consent before participating. Results The participants were predominantly middle-aged (mean 54.3, SD 13.3 years), white (80/86, 93%), and female (50/86, 58%). Use of oral T2DM medication correlated with the number of mean steps taken (r=.35, P=.001), whereas being unaware of the glycated hemoglobin level correlated with the number of minutes asleep (r=−.24, P=.04). On the basis of the Fitbit data, participants walked an average of 4955 steps and slept 6.7 hours per day. They self-reported an average of 2.0 days of exercise and 2.3 nights of sleep problems per week. The association between the number of days exercised and steps walked was strong (r=.60, P<.001), whereas the association between the number of troubled sleep nights and minutes asleep was weaker (r=.28, P=.02). Conclusions Fitbit and patient-reported data were positively associated for physical activity as well as sleep, with the former more strongly correlated than the latter. As extensive patient monitoring can guide clinical decisions regarding T2DM therapy, passive, objective data collection through wearables could potentially enhance patient care, resulting in better patient-reported outcomes.