Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Prenatal Exposure to Mercury, Perceived Stress, and Depression on Birth Outcomes in Suriname: Results from the MeKiTamara Study

Prenatal exposure to mercury, stress, and depression may have adverse effects on birth outcomes. Little is known on the influence of chemical and non-chemical stressors on birth outcomes in the country of Suriname. We assessed the influence of prenatal exposure to mercury, perceived stress, and depression on adverse birth outcomes in 1143 pregnant Surinamese women who participated in the Caribbean Consortium for Research in Environmental and Occupational Health-MeKiTamara prospective cohort study. Associations between mercury (≥1.1 μg/g hair, USEPA action level/top versus bottom quartile), probable depression (Edinburgh Depression Scale ≥12), high perceived stress (Cohen’s Perceived Stress Scale ≥20), and adverse birth outcomes (low birthweight (<2500 g), preterm birth (<37 completed weeks of gestation), and low Apgar score (<7 at 5 min)) were assessed using bivariate and multivariate logistic regressions. Prevalence of elevated mercury levels, high perceived stress, and probable depression were 37.5%, 27.2%, and 22.4%, respectively. Mercury exposure was significantly associated with preterm birth in the overall study cohort (OR 2.47; 95% CI 1.05–5.83) and perceived stress with a low Apgar score (OR 9.73; 95% CI 2.03–46.70). Depression was not associated with any birth outcomes. These findings can inform policy- and practice-oriented solutions to improve maternal and child health in Suriname.
In Vitro ADME, Preclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of RBx14255, a Novel Ketolide with Pharmacodynamics Against Multidrug-Resistant Bacterial Pathogens.

PURPOSE The preclinical pharmacokinetic and pharmacodynamic properties of a potent fluoroketolide RBx14255 against Streptococcus pneumoniae and Haemophilus influenzae was compared with telithromycin and human clinical dose was predicted for preclinical development. METHODS The in vitro pharmacokinetic characterization was performed for solubility, Caco-2 permeability, microsomal stability, CYP inhibition and plasma protein binding. In vivo pharmacokinetic studies were performed in Swiss albino mice, Sprague Dawley rats and Beagle dogs. The pharmacodynamic studies were carried out in mouse against S. pneumoniae in systemic infection and against S. pneumoniae and H. influenzae in rat lung infection models. RESULTS RBx14255 showed superior potency and efficacy in mouse and rat infection models. RBx14255 showed pH dependent solubility (0.41 mg/mL at pH 6.8 and >1 mg/mL at pH 1.2), moderate Caco-2 permeability (A to B: 12 nm/s) with high efflux ratio. It showed high plasma protein binding (>97%) in mouse and low binding (45- 70%) in rat, dog and human. The compound is mainly metabolized through CYP3A4. Pharmacokinetic parameters and absolute bioavailability of both, RBx14255 and telithromycin are similar in mouse. Both the ketolides showed low plasma clearance (18% of the normal hepatic blood flow rate) in mouse, moderate to high clearance in rat and dog. Mean oral bioavailability was high in mouse (≥85%), moderate in rat (RBx14255: 15% and telithromycin: 51%) and high to moderate in dog (RBx14255: 98% and telithromycin: 56%). The predicted efficacious dose for a 70 kg man ranges from 124 mg BID to 226 mg BID. CONCLUSION RBx14255 displayed significantly better pharmacodynamics which correlates with the pharmacokinetic properties against S. pneumoniae and H. influenzae as compared to telithromycin. The predicted human efficacious doses are in the range of 124-226 mg, making it amenable to oral dosage form drug in human. This could be a promising clinical candidate for future studies.
CARACTERIZACIÓN TEXTURAL Y FISICOQUÍMICA DEL QUESO EDAM

PHYSICAL-CHEMICAL AND TEXTURAL CHARACTERIZATION OF EDAM CHEESE. A physical-chemical and textural characterization of Edam cheese was conducted. The results indicated that the textural parameters such as the hardness, cohesiveness, adhesiveness and chewiness were dependent upon of the maturation period but not the springiness of the product. The physical-chemistry properties such as fat content, protein and moisture content also depended upon the maturation processing, with these changes being responsible for the modifications of the textural properties.
Undiagnosed hypothyroidism with delayed recovery: A case report

1. Agency for Healthcare Research and Quality. Making Health Care Safer: A Critical Analysis of Patient Safety Practices; 2001 2. Froehlich CD, Rigby MR, Rosenberg ES, Li R, Roerig PL, Easley KA, et al. Ultrasound‐guided central venous catheter placement decreases complications and decreases placement attempts compared with the landmark technique in patients in a pediatric intensive care unit. Crit Care Med 2009;37:1090‐6. 3. Stone MB, Nagdev A, Murphy MC, Sisson CA. Ultrasound detection of guidewire position during central venous catheterization. Am J Emerg Med 2010;28:82‐4. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
The efficacy of intralesional dexamethasone versus intravenous dexamethasone in surgery for impacted third molars: A randomized controlled trial

Objectives: A randomized prospective double-blind study was conducted to determine the efficacy of sub-mucosal local infiltration vs. intravenous dexamethasone in reducing postoperative pain, swelling and trismus after surgical removal of impacted mandibular third molars. Materials and Methods: Forty five patients were included in the study and were randomly divided into three groups. Each group consisted of 15 patients for which the first and second groups were given 8 mg of dexamethasone intrlesionally & intravenously respectively, at 30 minutes prior to surgery; the third group served as control. Duration of facial swelling was evaluated subjectively by the patients themselves. Severity of postoperative pain was quantified by counting the number of analgesics taken by the patients during and after surgery (six subsequent days). Postoperative trismus was determined by measuring the maximum incisal opening before surgery and on the seventh day. Results: Results showed that duration of postoperative edema was almost the same in the three test groups. During surgery, the intravenous dexamethasone group showed a significantly lesser pain than the other two groups; the intralesional dexamethasone group showed less marked pain than the control group. Additionally, patients who had taken steroids had a marked increase in the incisal opening postoperatively over the control group. Trismus was significantly reduced in the methylprednisolone group as compared to the dexamethasone group. Conclusion: It is concluded that both preoperative local infiltration and intravenous administration of dexamethasone significantly reduced postoperative pain and trismus after surgical removal of mandibular third molars. An intravenous dexamethasone is more effective in reducing postoperative inflammatory sequelae than its intralesional route.
Smoking in users of a cervical cancer screening center of the Mexican government at Mexico City

1. Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARSCoV2 pneumonia in Wuhan, China: A singlecentered, retrospective, observational study. The Lancet Respiratory Medicine 2020;8;475‐81. 2. Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Raffaela ND. Features, evaluation and treatment coronavirus (COVID19). In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020. Available from: https:// www.ncbi. nlm.nih. gov/books/ NBK554776/. [Last update on 2020 Mar 20]. 3. Gorbalenya AE, Baker SC, Baric RS, de Groot RJ, Drosten C, Anastasia A, et al. The species Severe acute respiratory syndrome‐ related coronavirus: classifying 2019‐nCoV and naming it SARS‐ CoV‐2. Nature Microbiology 2020;5:536‐44. 4. Suganthan N. Covid‐19. Jaffna Med J 2019;31:3‐8. 5. Li Q, Guan X. Early transmission dynamics in Wuhan, China, of novel coronavirus –Infected pneumonia. N Engl J Med 2020;382:1199‐207. 6. Thomas P, Baldwin C, Bissett B, Boden I, Gosselink R, Granger CL, et al. Physiotherapy management for COVID‐19 in the acute hospital setting: Recommendations to guide clinical practice. Version 1.0, published 23 March 2020. 7. Lee CM, Fan E. ICU‐acquired weakness: What is preventing its rehabilitation in critically ill patients? BMC Med 2012;10:115. 8. Nordon‐Craft A, Moss M, Quan D, Schenkman M. Intensive care unit‐acquired weakness: Implications for physical therapist management. Phys Ther 2012;92:1494‐506.
Effect of phloretin treatment ameliorated the cisplatin-induced nephrotoxicity and oxidative stress in experimental rats

Background: The cisplatin is one of the widely employed platinum-based drugs as the chemotherapeutic substance for the treatment of various cancers such as bladder cancer, prostate cancer, cervix cancer, and lung cancer. Hence, the present work was designed to test the curative efficacy of phloretin against the cisplatin-induced nephrotoxicity in rat model. Materials and Methods: Male Wistar albino rats were divided into five groups and the Group I rats were served as control, Group II rats were injected with cisplatin (8 mg/kg), Group III rats were administered with the low dose of phloretin (25 mg/kg), Group IV rats were administered with the high dose of phloretin (50 mg/kg), and the Group V rats were administered with the standard drug silymarin (50 mg/kg) for 10 days. After the experimental period, the animals have been sacrificed and collected all the samples for further analysis. Results: In the current study, the cisplatin was exhibited the severe renal damage in Wistar albino rats by possessing the various clinical complications such as increased serum urea, proteinuria and creatinine levels, decreased antioxidant enzymes level, increased DNA fragmentation, elevated oxidative stress, and severe injury to renal tissues. In addition, the cisplatin increased the poly (ADP-ribose) polymerase-1 and caspase-3 activity and pro-inflammatory cytokines level such as tumor necrosis factor alpha and interleukin-1 β. Whereas, the treatment with the low dose and high dose of phloretin (25–50 mg/kg) was exhibited a significant (P < 0.05) attenuation against the cisplatin-induced nephrotoxicity in experimental rats. Conclusion: The phloretin treatment significantly protected the kidneys against cisplatin-induced renal damages in rats.
Pulmonary blastomycosis in rural Upstate New York: A case series and review of literature

In a rural medical center in Upstate New York, we observed an increase in pulmonary blastomycosis cases. Herein, we highlight the increased prevalence of blastomycosis in our region, and our experience with the diagnostic dilemma resulting in delayed diagnosis. This delay may have resulted in an increased mortality. A high index of suspicion may help hasten the diagnosis in an otherwise nonendemic area. A single-center retrospective case series of all patients diagnosed with culture-proven blastomycosis is reported at the Bassett Medical Center from 2007 to 2019. Eight cases of confirmed pulmonary blastomycosis were identified. All patients resided in a rural area along the Susquehanna River Basin. Only one case had a travel history to an endemic state. Males accounted for 100% of cases. There was a 50% mortality rate from acute respiratory distress syndrome. Bronchoalveolar lavage (BAL) reliably made the diagnosis. About 40% of patients had a false-negative blastomycosis serology. There was an average delay of 2.5 months from presentation to correct diagnosis due to a lack of consideration for blastomycosis. BAL resulted in a correct diagnosis, while serology was not reliable to exclude the diagnosis. Physicians should include blastomycosis in the diagnostic differential cases of nonresolving pneumonia in Upstate New York, an area not previously considered as endemic. Bronchoalveolar remains the evaluation method of choice if blastomycosis is suspected.
Pluripotency‐associated genes reposition during early embryonic developmental stages in pigs

Abstract We examined the allelic expression and positioning of two pluripotency‐associated genes, OCT4 and SOX2, and two housekeeping genes, ACTB and TUBA, in 4‐ and 8‐cell porcine embryos utilizing RNA and DNA fluorescence in situ hybridization (FISH) in single blastomeres. The proportion of blastomeres expressing SOX2 bi‐allelically increased from 45% at the 4‐cell stage to 60% at the 8‐cell stage. Moreover, in 8‐cell embryos, SOX2 was expressed bi‐allelically in significantly more blastomeres than was the case for OCT4, and this was associated with a tendency for SOX2 alleles to move toward the nuclear interior during 4‐ to 8‐cell transition. However, the radial location of OCT4 alleles did not change significantly during this transition. The locations of active and inactive alleles based on DNA and RNA FISH signals were also calculated. Inactive OCT4 alleles were located in very close proximity to the nuclear membrane, whereas active OCT4 alleles were more centrally disposed in the nucleus. Nevertheless, the nuclear location of active and inactive SOX2 alleles did not change in either 4‐ or 8‐cell blastomeres. Our RNA and DNA FISH data provide novel information on the allelic expression patterns and positioning of pluripotency‐associated genes, OCT4 and SOX2, during embryonic genome activation in pigs.
Automatic Generation of Citation Texts in Scholarly Papers: A Pilot Study

In this paper, we study the challenging problem of automatic generation of citation texts in scholarly papers. Given the context of a citing paper A and a cited paper B, the task aims to generate a short text to describe B in the given context of A. One big challenge for addressing this task is the lack of training data. Usually, explicit citation texts are easy to extract, but it is not easy to extract implicit citation texts from scholarly papers. We thus first train an implicit citation extraction model based on BERT and leverage the model to construct a large training dataset for the citation text generation task. Then we propose and train a multi-source pointer-generator network with cross attention mechanism for citation text generation. Empirical evaluation results on a manually labeled test dataset verify the efficacy of our model. This pilot study confirms the feasibility of automatically generating citation texts in scholarly papers and the technique has the great potential to help researchers prepare their scientific papers.
Overexpression of FNTB and the activation of Ras induce hypertrophy and promote apoptosis and autophagic cell death in cardiomyocytes

Farnesyltransferase (FTase) is an important enzyme that catalyses the modification of protein isoprene downstream of the mevalonate pathway. Previous studies have shown that the tissue of the heart in the suprarenal abdominal aortic coarctation (AAC) group showed overexpression of FTaseβ (FNTB) and the activation of the downstream protein Ras was enhanced. FTase inhibitor (FTI) can alleviate myocardial fibrosis and partly improve cardiac remodelling in spontaneously hypertensive rats. However, the exact role and mechanism of FTase in myocardial hypertrophy and remodelling are not fully understood. Here, we used recombinant adenovirus to transfect neonatal rat ventricular cardiomyocytes to study the effect of FNTB overexpression on myocardial remodelling and explore potential mechanisms. The results showed that overexpression of FNTB induces neonatal rat ventricular myocyte hypertrophy and reduces the survival rate of cardiomyocytes. FNTB overexpression induced a decrease in mitochondrial membrane potential and increased apoptosis in cardiomyocytes. FNTB overexpression also promotes autophagosome formation and the accumulation of autophagy substrate protein, LC3II. Transmission electron microscopy (TEM) and mCherry‐GFP tandem fluorescent‐tagged LC3 (tfLC3) showed that FNTB overexpression can activate autophagy flux by enhancing autophagosome conversion to autophagolysosome. Overactivated autophagy flux can be blocked by bafilomycin A1. In addition, salirasib (a Ras farnesylcysteine mimetic) can alleviate the hypertrophic phenotype of cardiomyocytes and inhibit the up‐regulation of apoptosis and autophagy flux induced by FNTB overexpression. These results suggest that FTase may have a potential role in future treatment strategies to limit the adverse consequences of cardiac hypertrophy, cardiac dysfunction and heart failure.
Description of five new species of the diatom genus Luticola (Bacillariophyta, Diadesmidaceae) found in lakes of James Ross Island (Maritime Antarctic Region)

During a survey of the non-marine diatom flora from lakes on James Ross Island (Maritime Antarctic Region), five new Luticola species have been recorded: Luticola desmetii , L. doliiformis , L. evkae , L. permuticopsis and L. tomsui . Detailed morphology descriptions of these taxa are given based on both light (LM) and scanning electron microscopy (SEM). The morphological features of each taxon have been compared with similar taxa and notes on the ecology of the species have been added.
Extraction, isolation and identification of kaempferol 3,7 – Diglucoside in the leaf extracts of Evolvulus alsinoides (Linn.) and its inhibition potency against α-amylase, α-glucosidase, Acetylcholinesterase and amyloid aggregation

Background: Evolvulus alsinoides (Linn.) is an eminent kaphahara (balancing kapha ) plant in Ayurvedic medicine commonly used as brain tonic. Objectives: To report the enzyme inhibitory potency of the plant extract and to isolate the compound of significant impact. Materials and Methods: The plant extracts were obtained by serial exhaustive extraction and successive chromatographic separation. Antioxidant and enzyme inhibition assays were carried out to extract the required isolate. Results: The current research identifies for the first time, the presence of Kaempferol 3,7 diglycoside in the leaf extracts by Spectrophotometry, Chromatography,[1]H and[13]C Nuclear Magnetic Resonance, carboxylic and hydroxylic hydrolysis. The isolated and characterized compound possesses enzyme inhibition property towards α-amylase, α-glucosidase and Acetylcholinesterase . Conclusion: The compound protects differentiating neuronal cells, SH-SY5Y from Amyloid β Peptide-induced Injury. Thus, the newly identified compound could serve as a plant-based bioactive in the management of Alzheimer's.
Preemergence Herbicides Influence Sprig Establishment of ‘TifEagle’ Bermudagrass

Abstract The presence of weeds during bermudagrass putting green establishment can reduce growth and turf quality. Three field experiments were conducted in Georgia to investigate efficacy of dimethenamid, S-metolachlor, and oxadiazon on the establishment of ‘TifEagle’ bermudagrass from sprigs. Dimethenamid at 0.85 and 1.7 kg ai ha−1, S-metolachlor at 1.1 and 2.2 kg ai ha−1, and oxadiazon at 1.1, 2.2, and 4.4 kg ai ha−1 did not reduce bermudagrass cover from the untreated after 8 wk. S-metolachlor at 4.4 kg ha−1 was the only treatment that reduced sprig cover from the untreated after 12 wk. All S-metolachlor and oxadiazon treatments provided excellent (≥ 90%) green kyllinga control by 8 wk after treatment (WAT) while dimethenamid at 0.85, 1.7, and 3.4 kg ha−1 provided 78, 85, and 92% control, respectively. Dimethenamid treatments provided poor control (< 70%) of spotted spurge but fair control (70 to 79%) was achieved from S-metolachlor at 4.4 kg ha−1 and oxadiazon at 2.2 and 4.4 kg ha−1 by 8 WAT. Overall, low to middle rates of the herbicides tested appear to temporarily inhibit TifEagle bermudagrass sprig establishment but high rates of dimethenamid and S-metolachlor may reduce cover from the untreated. Nomenclature: Hybrid bermudagrass, Cynodon dactylon × C. transvaalensis Burtt-Davy; green kyllinga, Kyllinga brevifolia Rottb. ; spotted spurge, Euphorbia maculata L.
The involvement of people with dementia in advocacy: a systematic narrative review

Abstract Objectives This Prospero-registered review sought to answer three questions concerning people with dementia involved in speaking out on behalf of themselves and others as dementia advocates. First, what are the views and motivations of the people involved? Second, what impact does this have upon them and others? Third, what are the future policy and research implications? Methods A systematic search and narrative synthesis of original research was conducted. Searches in Pubmed, Web of Science, PsychINFO and CINAHL followed PRISMA Guidelines. The review focused on people with dementia involved in advocacy. There were no restrictions based on study design or date. Language was limited to English. Results Seven papers were identified, with predominantly qualitative methodologies. Four overarching themes were identified: threats, fighting back, evolving identities and making a difference. Threats ranged from those arising from dementia as an illness, to exposure to stigma. Fighting back represented advocates’ response to these threats, often described using martial metaphors. Evolving identities captured advocates’ journeys through diagnosis to involvement in advocacy and subsequent impact upon identity. Making a difference represented the impact of dementia advocacy at an individual, community and societal level. Conclusions This review confirms that the threats associated with dementia extend beyond the symptoms of illness. Dementia advocacy offers potential improvements in well-being for those involved, through the activity itself and via extended social networks. There is little research on broader aspects of advocates’ identity, including ethnicity, gender, and age. There has been little attempt to quantify the impact of dementia advocacy.
Staufen1 localizes to the mitotic spindle and controls the localization of RNA populations to the spindle

ABSTRACT Staufen1 (STAU1) is an RNA-binding protein involved in the post-transcriptional regulation of mRNAs. We report that a large fraction of STAU1 localizes to the mitotic spindle in colorectal cancer HCT116 cells and in non-transformed hTERT-RPE1 cells. Spindle-associated STAU1 partly co-localizes with ribosomes and active sites of translation. We mapped the molecular determinant required for STAU1–spindle association within the first 88 N-terminal amino acids, a domain that is not required for RNA binding. Interestingly, transcriptomic analysis of purified mitotic spindles revealed that 1054 mRNAs and the precursor ribosomal RNA (pre-rRNA), as well as the long non-coding RNAs and small nucleolar RNAs involved in ribonucleoprotein assembly and processing, are enriched on spindles compared with cell extracts. STAU1 knockout causes displacement of the pre-rRNA and of 154 mRNAs coding for proteins involved in actin cytoskeleton organization and cell growth, highlighting a role for STAU1 in mRNA trafficking to spindle. These data demonstrate that STAU1 controls the localization of subpopulations of RNAs during mitosis and suggests a novel role of STAU1 in pre-rRNA maintenance during mitosis, ribogenesis and/or nucleoli reassembly. Highlighted Article: The RNA-binding protein Staufen1 mediates the localization of pre-ribosomal RNAs on mitotic spindle suggesting a novel role of Staufen1 in ribosome biogenesis and nucleoli reassembly.
Kırsal Rekreasyonel Faaliyetlerde Kısıtlayıcılar

The purpose of the study is to determine both the frequency of participation to recreational activities, and the constrains that effect participation frequency. For this purpose and inquiry has been done with 250 people in 2004 spring semester. Five point Likert scale has been used to evaluate the constrains and participations. In order to determine the types of constrains from the data obtained factor analize has been used. According to this, the constrains can be grouped as follows, a person's physiology, friends, economic status, self- respect, lack of recreation sites, inter- personal reasons, and time.