Miracle-dz/UniFAR-FTUs huggingface dataset:
Calibration of Passive Samplers for the Monitoring of Pharmaceuticals in Water-Sampling Rate Variation

ABSTRACT Passive sampling is one of the most efficient methods of monitoring pharmaceuticals in environmental water. The reliability of the process relies on a correctly performed calibration experiment and a well-defined sampling rate (Rs) for target analytes. Therefore, in this review the state-of-the-art methods of passive sampler calibration for the most popular pharmaceuticals: antibiotics, hormones, β-blockers and non-steroidal anti-inflammatory drugs (NSAIDs), along with the sampling rate variation, were presented. The advantages and difficulties in laboratory and field calibration were pointed out, according to the needs of control of the exact conditions. Sampling rate calculating equations and all the factors affecting the Rs value – temperature, flow, pH, salinity of the donor phase and biofouling – were discussed. Moreover, various calibration parameters gathered from the literature published in the last 16 years, including the device types, were tabled and compared. What is evident is that the sampling rate values for pharmaceuticals are impacted by several factors, whose influence is still unclear and unpredictable, while there is a big gap in experimental data. It appears that the calibration procedure needs to be improved, for example, there is a significant deficiency of PRCs (Performance Reference Compounds) for pharmaceuticals. One of the suggestions is to introduce correction factors for Rs values estimated in laboratory conditions.
Gene cluster for dissimilatory nitrite reductase (nir) from Pseudomonas aeruginosa: sequencing and identification of a locus for heme d1 biosynthesis

The primary structure of an nir gene cluster necessary for production of active dissimilatory nitrite reductase was determined from Pseudomonas aeruginosa. Seven open reading frames, designated nirDLGHJEN, were identified downstream of the previously reported nirSMCF genes. From nirS through nirN, the stop codon of one gene and the start codon of the next gene were closely linked, suggesting that nirSMCFDLGHJEN are expressed from a promoter which regulates the transcription of nirSM. The amino acid sequences deduced from the nirDLGH genes were homologous to each other. A gene, designated nirJ, which encodes a protein of 387 amino acids, showed partial identity with each of the nirDLGH genes. The nirE gene encodes a protein of 279 amino acids homologous to S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase from other bacterial strains. In addition, NirE shows 21.0% identity with NirF in the N-terminal 100-amino-acid residues. A gene, designated nirN, encodes a protein of 493 amino acids with a conserved binding motif for heme c (CXXCH) and a typical N-terminal signal sequence for membrane translocation. The derived NirN protein shows 23.9% identity with nitrite reductase (NirS). Insertional mutation and complementation analyses showed that all of the nirFDLGHJE genes were necessary for the biosynthesis of heme d1.
Readout ASIC With SOI Technology for X-Ray CCDs

We developed an analog front-end application specific integrated circuit (ASIC) with a fully depleted (FD) silicon-on-insulator (SOI) technology for readout of X-ray CCDs. The ASIC contains seven readout channels, each of which is equipped with the correlated double sampling circuit followed by an amplitude-to-pulse width conversion circuit. We combined the ASIC with an X-ray CCD for performance evaluation tests. We succeeded in processing analog signals from the CCD and confirmed an X-ray imaging and photon-counting capabilities by irradiating a radioisotope 55Fe. The energy resolution is 305 eV at 5.9 keV (full-width at half maximum) and the readout noise is 53.7 μV for power consumption of 33 mW per chip. The ASIC proves that the FD-SOI process can be a practically usable option for front-end applications.
Maximum power transfer scheme for magnetic resonance charging system

Magnetic resonance coupling technique has a very high efficiency and long distance for wireless charging. With multiple transmitter coils, the power transmission efficiency can be further improved. In this paper, we propose a maximum power transfer scheme in magnetic resonance coupling wireless charging system. We construct the system model to analyze the system power transmission in different situations. The received power get maximum with a constrained transmitted power by applying the proposal scheme. The 6.78MHz charging experimental results demonstrate that the received power at multi-receive coils can be increased to 10 times at best by using our scheme compared with the equal power allocation.
The NADPH oxidase Nox 4 restricts the replicative lifespan of human endothelial cells

Barbara LENER*†1, Rafał KOZIEŁ*1, Haymo PIRCHER*, Eveline HÜTTER*, Ruth GREUSSING*, Dietmar HERNDLER-BRANDSTETTER*, Martin HERMANN‡, Hermann UNTERLUGGAUER* and Pidder JANSEN-DÜRR*†2 *Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, A-6020 Innsbruck, Austria, †Tyrolean Cancer Research Institute, Innrain 66, A-6020 Innsbruck, Austria, and ‡KMT Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Innsbruck Medical University, Innrain 66, A-6020 Innsbruck, Austria
Coordinate expression of coproporphyrinogen oxidase and cytochrome c6 in the green alga Chlamydomonas reinhardtii in response to changes in copper availability.

To maintain photosynthetic competence under copper‐deficient conditions, the green alga Chlamydomonas reinhardtii substitutes a heme protein (cytochrome c6) for an otherwise essential copper protein, viz. plastocyanin. Here, we report that the gene encoding coproporphyrinogen oxidase, an enzyme in the heme biosynthetic pathway, is coordinately expressed with cytochrome c6 in response to changes in copper availability. We have purified coproporphyrinogen oxidase from copper‐deficient C.reinhardtii cells, and have cloned a cDNA fragment which encodes it. Northern hybridization analysis confirmed that the protein is nuclear‐encoded and that, like cytochrome c6, its expression is regulated by copper at the level of mRNA accumulation. The copper‐responsive expression of coproporphyrinogen oxidase parallels cytochrome c6 expression exactly. Specifically, the copper‐sensing range and metal selectivity of the regulatory components, as well as the time course of the responses, are identical. Hence, we propose that the expression of these two proteins is controlled by the same metalloregulatory mechanism. Our findings represent a novel metalloregulatory response in which the synthesis of one redox cofactor (heme) is controlled by the availability of another (Cu).
CE: Cardiotoxicity and Breast Cancer as Late Effects of Pediatric and Adolescent Hodgkin Lymphoma Treatment

&NA;The American Cancer Society estimates that in 2014 nearly 16,000 U.S. children and adolescents developed cancer, and in roughly 1,200 of these cases the cancer was Hodgkin lymphoma (HL). The great majority of these patients will survive, joining the thousands who have been diagnosed and treated successfully in decades past. Nurses’ familiarity with and attention to the late effects of the chemotherapy and radiation therapy used to treat HL, which include breast cancer as well as cardiotoxicity and its sequelae, are essential in helping these patients maintain their overall health.
Trade and Variety in a Model of Endogenous Product Differentiation

Abstract This paper sets up a model of endogenous product differentiation to analyze the variety effects of international trade. In our model multi-product firms decide not only about the number of varieties they will supply but also about the degree of horizontal differentiation between these varieties. Firms can raise the degree of differentiation by investing variety-specific fixed costs. In this setting, we analyze how trade integration, i.e. an increase in market size, influences the number of firms in the market, the number of product varieties supplied by each firm, and the degree of differentiation between these varieties.
Ovary development in bandicoots: sexual differentiation to follicle formation.

While our knowledge of marsupial gonadogenesis is still rather scant, the few studies that have been carried out recently indicate that the course of development in this group of animals may not only show seemingly unique features (Ullmann, 1978) but may also throw light on longstanding and unresolved controversies concerning eutherian gonadogenesis (Ullmann, 1981 b, 1984). Though the origin and migration of the primordial germ cells in bandicoots appear to conform to the eutherian pattern (Ullmann, 1981 a), the sexual differentiation of the gonad has been shown to occur in the absence of mesothelial proliferations (Ullmann, 1981 b) contrary to most textbook accounts of the development of this organ in mammals (e.g. Balinsky, 1981; Sadler, 1985). For marsupials an account of early ovary formation has been given by Alcorn (1975) for the Tammar wallaby Macropus eugenii; while follicle development has been described in the Virginia opossum Didelphis virginiana (Morgan, 1943) and M. eugenii (Alcorn & Robinson, 1983). Oocyte and follicle growth characteristics have been studied by Lintern-Moore, Moore, Tyndale-Biscoe & Poole (1976). This paper, after a brief review of the early differentiation of the gonads, describes the development of the ovary in the bandicoot from the first week after birth till the onset of folliculogenesis in the fifth week of pouch life.
Investigating Social Commerce as an Alternate Model for Online Commerce in Developing Countries: a case of Pakistani Economy

The study is an empirical quantitative research. In light of intense literature review it proposes a new model for effectiveness of social commerce in Pakistan. It has three objectives. It firstly investigates the relationship between perceived risk, social networking focus, and perceived value effect trust. It secondly investigates the relationship between affective influence, word of mouth, affective influence, advertising influence, purchasing experience and viral reach on social commerce. Lastly it investigates how consumer value (adoption and purchase intention is affected by social commerce focus and trust. The software used is SPSS 15.0. Multiple regression equation has been employed to verify the hypotheses. Results show and validate the literature that positive or favorable views of users trigger positive attitude. However, there are two variables and dimensions that do not affect the attitude of users on social networks from the perspective of shopping i.e. social commerce; these are viral reach and previous purchasing experience on different websites. The results show that Pakistani users will welcome social commerce even if they have no previous experience for purchasing goods and services online.
Aggregation of the web performance of internal university units as a method of quantitative analysis of a university system: the case of Spain

The aggregation of web performance data (page count and visibility) of internal university units could constitute a more precise indicator than the overall web performance of the universities and, therefore, be of use in the design of university web rankings. In order to test this hypothesis, a longitudinal analysis of the internal units of the Spanish university system was conducted over the course of 2010. For the 13,800 URLs identified, page count and visibility were calculated using the Yahoo! API. The internal values obtained were aggregated by university and compared with the values obtained from the analysis of the universities' general URLs. The results indicate that, although the correlations between general and internal values are high, internal performance is low in comparison to general performance, and that they give rise to different performance rankings. The conclusion is that the aggregation of unit performance is of limited use due to the low levels of internal development of the websites, and so its use is not recommended for the design of rankings. Despite this, the internal analysis enabled the detection of, among other things, a low correlation between page count and visibility due to the widespread use of subdirectories and problems accessing certain content.
Localization Algorithm based on Improved Weighted Centroid in Wireless Sensor Networks

Location technology is becoming more and more important in wireless sensor networks. The weighted centroid localization offers a fast and simple algorithm for the location equipment in wireless sensor networks. The algorithm derives from the centroid measurement and calculation device of the adjacent anchor in the average coordinate. After the analysis of the radio propagation loss model, the most appropriate log-distance distribution model is selected to simulate the signal propagation. Based on the centroid algorithm and the weighted centroid algorithm, this paper proposes an ellipse centroid localization algorithm. This algorithm makes use of ellipse’s characteristic to estimate the unknown node’s coordinate. The main idea of ellipse centroid localization algorithm is the precision control factor that can control the algorithm’s location precision. In ellipse centroid localization algorithm, node is extended as anchor in order to strengthen anchor density’s dynamic characteristic. The simulation result shows the ellipse centroid localization algorithm is more effective than the centroid algorithm and the weighted centroid precision algorithm
Corporate Governance Characteristics and Company Performance of Family Owned and Non-Family Owned Businessess in India

This paper studies the impact of promoters' family control and corporate governance on firm value. Purposive sampling method was adopted to choose sample firms from those listed in the Bombay Stock Exchange (BSE). Of the 4573 firms listed in BSE, banking, insurance and financial firms were excluded as they are governed by different bodies. Foreign firms and companies acquired during the period of investigation were also excluded. So a sample of 771 firms during the period 2001 to 2005 was studied. The data were analyzed using 't' test to find the difference in the firm value between promoter family controlled and non- promoter family controlled firms. Multiple regression analysis was conducted to identify the factors that affect firm value. This study found that the firm value is not significantly affected by the ownership type of the firm.
Vasculogenesis and erythropoiesis in the living yolk sac of the chick embryo a phase microscopic study

Vasculogenesis and hemopoiesis in the yolk sac of various animals have been studied extensively in the past (Block, '46; Bloom, '38; Danchakoff, '16, '18; Dawson, '36; Doan et al., '25; Gilmour, '41; His, '00; Jones, '43, '47; Jordan, '16, '17; Maximow, '09, '24; Miller et al., '14; Reagan, '17; Sabin, '20a,b, '22; Sugiyama, '26) although they have not been examined in detail since the early works of Sabin ('20a,b) and Maximow ('09, '24). Recent investigations of these developmental processes using phase contrast (Borghese et al., '55; Jones, '47) and electron (Sorenson, '59) microscopy as well as histochemistry (GireUi, '57; Jones, '47) have been exceedingly few. Newer developments in microscopy particularly those permitting the ready visualization of the intact living cell provide new techniques for the study and reassessment of the process of vasculogenesis and hernopoiesis in the embryonic yolk sac. Phase microscopy makes possible the visualization of cellular morphology and activity with a clarity never possible in the early days of morphologic and embryologic hematology. Therefore, it is the purpose of this investigation to describe and illustrate stages in the process of blood vessel formation (vasculogenesis) and erythropoiesis in the living yolk sac of the chick embryo using the phase contrast microscope.
Progressive muscular dystrophy: autosomal recessive type.

A description is presented of the autosomal recessive type of childhood muscular dystrophy appearing in 14 members (9 males, 5 females) of one closely inbred kindred. The clinical description of these individuals is supplemented by data on values for proteins, protein-bound iodine, hexosamine and glutamic oxaloacetic transaminase in serum, and excretion of amino acids and creatine-creatinine. In comparing this autosomal recessive type with the more common sex-linked recessive type of childhood muscular dystrophy, the most reliable differentiating feature noted was the presence of dystrophy in a female within a family. The muscle involvement in these two types of diseases was similar except for the preservation of the zygomaticus muscles of the face in the autosomal recessive type as compared with the involvement of these muscles and resultant flat smile in the sexlinked recessive type of dystrophy. Pseudohypertrophy of the calf muscles occurred in 4 of 14 affected individuals of this kindred and therefore cannot be considered a dependable differentiating feature. The patients with the autosomal recessive type of muscular dystrophy had a later age of onset (5 to 13 years), a slower progression and a possible longer life span than those having the sex-linked recessive type. The importance of differentiating muscular dystrophy into types based on mode of inheritance is emphasized.
Modulation of osteoclast differentiation.

I. Introduction BONE is a complex tissue in which resorption and formation continue throughout life. This process is called bone remodeling. Osteotropic hormones such as 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], PTH, and calcitonin preferentially modulate the process of bone resorption to maintain bone remodeling. The bone tissue contains various types of cells, of which the bone-forming osteoblasts and bone-resorbing osteoclasts are mainly responsible for bone remodeling. Osteoblasts are believed to be derived from undifferentiated mesenchymal cells, which further differentiate into osteocytes and are embedded in calcified tissues. Osteoclasts are multinucleated cells present only in bone. It is believed that osteoclast progenitors are of hemopoietic origin, and they are recruited from hemopoietic tissues such as bone marrow and circulating blood to bone. Osteoclast progenitors then proliferate and differentiate into mononuclear preosteoclasts and fuse with each other to form multinucleated osteoclasts.
Metabolic profiles in goat does in late pregnancy with and without subclinical pregnancy toxemia.

BACKGROUND Pregnant goat does can develop various metabolic diseases during late pregnancy that may have profound effects on their health and productivity, including subclinical pregnancy toxemia. OBJECTIVES This study was performed to evaluate serum biochemical findings in goats in late pregnancy with and without subclinical pregnancy toxemia. METHODS Serum samples were obtained from 153 clinically healthy goats in the last trimester of pregnancy from 14 herds in central and northern Jordan. Serum was analyzed for the following constituents: 3-hydroxybutyrate (3-HB), glucose, total protein, albumin, urea, creatinine, aspartate aminotransferase, alkaline phosphatase, cholesterol, triglycerides, cortisol, T3, T4, total calcium, magnesium, and phosphorus, using commercially available kits. Goats were classified as having subclinical pregnancy toxemia or as controls on the basis of 3-HB results. Biochemical results were compared between the 2 groups using nonparametric statistical tests. RESULTS Fifty-three does had subclinical pregnancy toxemia (3-HB>0.86 mmol/L) and 100 were pregnant control does (3-HB< or =0.86 mmol/L). Does with subclinical pregnancy toxemia had significantly lower glucose concentrations (P<.001) and significantly higher urea (P=.042) and total protein (P=.048) concentrations compared with pregnant control does. 3-HB concentration was significantly correlated with glucose (r=0.290, P=.035), phosphorus (r=0.351, P=.01), and cortisol (r=0.394, P=.004) concentrations in goats with subclinical toxemia. CONCLUSIONS Results of this study indicate that the biochemical profile of does with subclinical pregnancy toxemia had significantly lower glucose (P < .001) and total protein (P = .048)concentrations, whereas urea concentrations were significantly higher (P = .042) compared with pregnant control does [corrected].
Educational Intervention for Patients with Atrial Fibrillation

It is estimated that there will be more than 15.9 million people suffering from AF worldwide by 2050. To further explore the effectiveness of educational intervention with social support on lowering the uncertainty in illness, this article presents a proposal of a care program with phone follow up among patients with AF. The uncertainty of the illness is found to be appraised as a danger among individuals with AF which brought them anxiety. the effects of educational interventions were mixed and the effects might not persist. Studies also showed that specialized care for patients with AF resulted in less emergency department visit and less hospitalizations AF patients with greater social support experienced significantly less uncertainty in illness while their educational level was not associated with uncertainty. Nurses were recommended to maximize patients’ perceived social support when intervening uncertainty in illness among AF patients. The proposed project concerning educational interventions with social support through group sessions and phone follow up should result in better patient outcomes.
Image mixed blur classification and parameter identification based on cepstrum peak detection

Motion blur and out-of-focus blur are two main components of image blur in most cases. Blur classification and parameter identification are very important for image processing such as image restoration. In this paper, a novel method based on cepstrum peak detection is presented to classify and identify three types of image blur including motion blur, out-of-focus blur and mixed blur. First, frequency information of detected image is utilized to determine the image blur. Then we classify the image blur in cepstrum domain. Next the parameters of image blur are identified according to the peak distribution of blurred image in cepstrum domain. Lastly, extensive experiments are carried out to verify the performance of our algorithm. Experiment results show that our method leads to performance improvements over state-of-the-arts methods.
Analysis of handoff algorithms using both absolute and relative measurements

An analytic model has been previously developed for evaluating the performance of handoff algorithms based on relative signal strength measurements, i.e., the difference of signal strength from two base stations (BS). In this paper we have extended this analysis by including an additional criterion based on absolute signal strength in the handoff decision algorithm. The absolute signal strength is the averaged value of the received signal level from current serving BS measured by the mobile unit. Recommended, e.g., in the GSM system, this value has to be below a fixed threshold to initiate a handoff (a necessary, not sufficient condition). In this way the mobile unit should be assigned to a new BS if the absolute signal strength from the old BS drops below the threshold and the relative signal strength between the new and old BS reaches the hysteresis level. The model is proved to be sufficiently accurate by comparison with simulation. The effect of adding absolute signal strength is illustrated. <<ETX>>
Hemorrhagic brain metastases with high signal intensity on diffusion-weighted MR images: A case report

Diffusion-weighted MR imaging has been applicable to the differential diagnosis of abscesses and necrotic or cystic brain tumors. However, restricted water diffusion is not necessarily specific for brain abscess. We describe ring-enhancing metastases of lung carcinoma characterized by high signal intensity on diffusion-weighted MR images. The signal pattern probably reflected intralesional hemorrhage. The present report adds to the growing literature regarding the differential diagnosis of ring-enhancing brain lesions.