Miracle-dz/UniFAR-FTUs huggingface dataset:
A candidate precursor to serous carcinoma that originates in the distal fallopian tube

The tubal fimbria is a common site of origin for early (tubal intraepithelial carcinoma or TIC) serous carcinomas in women with familial BRCA1 or 2 mutations (BRCA+). Somatic p53 tumour suppressor gene mutations in these tumours suggest a pathogenesis involving DNA damage, p53 mutation, and progressive loss of cell cycle control. We recently identified foci of strong p53 immunostaining—termed ‘p53 signatures’—in benign tubal mucosa from BRCA+ women. To examine the relationship between p53 signatures and TIC, we compared location (fimbria vs ampulla), cell type (ciliated vs secretory), evidence of DNA damage, and p53 mutation status between the two entities. p53 signatures were equally common in non‐neoplastic tubes from BRCA+ women and controls, but more frequently present (53%) and multifocal (67%) in fallopian tubes also containing TIC. Like prior studies of TIC, p53 signatures predominated in the fimbriae (80–100%) and targeted secretory cells (HMFG2 + /p73−), with evidence of DNA damage by co‐localization of γ‐H2AX. Laser‐capture microdissected and polymerase chain reaction‐amplified DNA revealed reproducible p53 mutations in eight of 14 fully‐analysed p53 signatures and all of the 12 TICs; TICs and their associated ovarian carcinomas shared identical mutations. In one case, a contiguous p53 signature and TIC shared the same mutation. Morphological intermediates between the two, with p53 mutations and moderate proliferative activity, were also seen. This is the first report of an early and distinct alteration in non‐neoplastic upper genital tract mucosa that fulfils many requirements for a precursor to pelvic serous cancer. The p53 signature and its malignant counterpart (TIC) underline the significance of the fimbria, both as a candidate site for serous carcinogenesis and as a target for future research on the early detection and prevention of this disease. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
INVITRO ANTIOXIDANT ACTIVITY OF CRUDE EXTRACTS OF THE PLANT GLYCOSMIS PENTAPHYLLA CORREA

This study was conducted to investigate the antioxidant effect of the different crude extracts (Petroleum ether, ethanolic and aqueous) of the plant Glycosmis pentaphylla correa. The antioxidant activity was evaluated by various antioxidant assays, including 1, 1-diphenyl-2-picrylhydrazyl (DPPH), 2, 2’-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), nitric oxide and hydrogen peroxide (H2O2) scavenging method. The antioxidant activities were compared to standard antioxidant ascorbic acid. Glycosmis pentaphylla correa ethanolic crude extract showed a significant antioxidant activity in DPPH, ABTS, nitric oxide and H2O2 scavenging methods. The findings of the present study suggested that Glycosmis pentaphylla could be a potential natural source of antioxidants and could have greater importance as therapeutic agent in preventing or slowing oxidative stress related degenerative diseases.
Autonomous Strapdown Attitude and Heading Reference System for a Small Agile UAV

The paper presents the results of a Kalman filter-based autonomous attitude and heading reference system design for a small agile fixed-wing UAV. MEMS accelerometers and gyros, 3-axis magnetometer and a barometric altimeter are used to obtain orientation angles estimations. The proposed system comprises several new structural units: an accelerometers preprocessor, a maneuver analyzer, a vertical estimation tract and a magnetometer continuous calibration tract, which reduces estimation errors of orientation angles. The system precision is experimentally verified and amounts to 0.3 degrees for roll and pitch angles and 1.5 degrees for yaw angle.
Genomics of plant genetic resources: an introduction

This special issue of Plant Genetic Resources has assembled 52 short articles selected among the over 350 oral and poster communications presented during the 2nd International Symposium on Genomics of Plant Genetic Resources (GPGR2; www.GPGR2.com) held in Bologna, Italy, from April 24 to 27, 2010. The second edition of GPGR2, co-organized by Bioversity International, the Leibniz Institute of Plant Genetics and Crop Plant Research and the University of Bologna, followed the first edition organized in 2005 by the Chinese Academy of Agricultural Science in Beijing, China.
A Multiple-Feed Connected Leaky Slot Antenna for In-Antenna Power Combining in 0.13 μm SiGe BiCMOS Technology

In this paper, a differentially-driven wideband multiple-feed on-chip antenna design in $0.13\ \mu \mathrm{m}$ SiGe technology is proposed for millimeter-wave power combining applications. The in-antenna power combining concept is achieved by combining parallel amplifiers in the multi-port radiator where each port corresponds directly to a differential power amplifier (PA) stage. Specifically, the radiator is composed of a leaky slot with multiple set of differential microstrip feed lines. A wideband Marchand balun with 1.5 dB insertion loss is applied to convert the differential output to the single-ended input of microstrip feed line. In addition, the proposed differential PA has a combined output power of 10 dBm and its output is directly connected with the balun. As a result, the proposed multiple-feed antenna has four differential microstrip feed lines connected with four Marchand baluns which are driven by four parallel differential PAs respectively. Also, to compensate for the loss along the signal route such as power splitters and baluns, pre-amplification PA stage is a necessity at the input of each PA stage. In order to suppress the surface waves in the high permittivity substrate, an extended hemispherical silicon lens is integrated with the chip. Simulation results show that the antenna can cover more than 50 % fractional bandwidth at 250 GHz and calculated EIRP is 19.3 dBm.
A Triple-layer Wideband Transmitarray Antenna Using Finger-Type Slot Elements

A novel triple-layer wideband transmitarray antenna using finger-type slot elements is presented in this paper. The unit-cell contains five longitudinal slots and a transverse slot on every thin metal layer, the simulated transmission coefficients of the unit-cell indicate that low loss and wideband properties are achieved at Ku-band. A wideband TA with diameter of 7.1 wavelengths using the proposed unit-cell is designed and simulated by commercial software Ansys 18.0. Simulated gain of 21.2 dBi at the center working frequency of 13.58 GHz and -1dB gain bandwidth of 24.3% are achieved at Ku band. The simulated radiation patterns of TA show that low side lobe level and low cross polarization level are reached in broadband range.
Wide Beamwidth Circularly Polarized Slot Loaded Microstrip Patch Antenna

The coupled fields between the slots are physically analyzed for wide 3-dB axial ratio beamwidth (ARBW) of a circularly polarized (CP) antenna. The square shaped CP antenna is decorated with a rectangular slot along one diagonal line of the patch and a pair of cross slots along another diagonal line. Dimensions of cross slots play a crucial role in adjusting the 3-dB ARBW of this CP antenna. This antenna offers the impedance bandwidth (IBW) of 83 MHz (2.443-2.526 GHz), CP bandwidth (CPBW) of 17 MHz (2.4462.463 GHz), and a maximum realizable gain of 4.28 dBic. The proposed left handed CP (LHCP) antenna exhibits wide 3-dB ARBW of 224° and 212° at φ =0° and φ=90° planes, respectively.
Ultra-Wide Band Non-Dispersive Leaky-Wave Antenna Based on Glide-Symmetric Meandered Transmission Lines

We present an ultra-wide band planar Luneburg lens based on glide-symmetric meandered transmission lines. In order to make the structure radiate, a non-dispersive leaky-wave structure is designed. The whole structure produces a pencil beam with steering capabilities from -60° to 60° in the azimuth direction from 10 to 20 GHz.
Editorial

The field of dementia, particularly in the UK, has witnessed a sea change in approach and philosophy over the last 10 years. The shift in understanding from purely a medical model to a more person-centred and relationshipfocused approach is significant and increasingly embedded within government policy (Department of Health, 2001). However, whilst this is of interest, perhaps the more pertinent questions relate to the nascent processes of knowledge transfer and exchange that have underpinned this process. For example: How have key messages and thinking about dementia care influenced quality of care? How have they exerted influence and change across policy, practice and research arenas? What is the impact of an increasing acknowledgment of the importance of the personal experience of people with dementia? Debating and exploring how knowledge is created, privileged and shared is increasingly coming under the spotlight (de Leeuw et al 2008; Nutley, Walter, & Davies, 2007). Underpinning the policy and practice imperative for ‘evidence-based’ care is the necessity for understanding what is evidence and how do types of evidence then operate in practice? Recently, the Scottish Government has set clear targets for the care of people with dementia (see for example NHS QIS, 2007) and by adopting this position, it has sent out strong essential messages to practice about approaches to dementia care. Advice on the policy formation and the implementation aspects of the work has been supported through a Dementia Forum of key stakeholders in Scotland. One of the products of this forum has been a ‘HEAT’ target (Health improvement, Efficiency and governance, Access and Treatment) for dementia (Scottish Government, 2008). HEAT targets are a de men tia
Groove Gap Waveguide Slot Array Based on Glide-Symmetric Holes

Gap waveguide technology enables a cost-effective and low-loss manufacturing of high frequency fully metallic components. With this technology, the microwave components can be made in two pieces that are assembled together afterwards. Between these two pieces, an undesired air gap due to surface roughness or manufacturing tolerances may cause energy leakage. To prevent this leakage, periodic structures that produce electromagnetic bandgaps (EBGs) are used. Here, we compare the performances of two holey EBG surfaces, which are a conventional holey periodic metasurface and a metasurface with glide symmetry. The glide-symmetric structure has a wider EBG and a similar leakage prevention with less number of hole rows. Using glide-symmetric holes, a $4 \times 4$ slot array antenna is designed. This slot array is excited with the TE40 mode and has a rotationally symmetric radiation pattern.
A Broadband Transition From Microstrip to Groove Gap Waveguide For Ka-Band Applications

This paper describes a wideband and low-loss microstrip to groove gap waveguide transition for millimeter wave applications. The microstrip mode is effectively transformed into the groove gap waveguide (GGW) mode by means of a slot-line. The simulation results of the transition show an insertion loss of 0.3 dB and a return loss less than 20 dB over 42.5% relative bandwidth from 26 to 40 GHz.
Dual-Polarized mm-Wave Antenna Solution for Mobile Phone

This article describes a novel dual-polarized mm-wave antenna for mobile phone devices. The mm-wave antenna module consists of a 4-layer PCB, an extra metallic piece acting as a reflector, and four metallic pins. The four metallic pins are placed on the top layer of the PCB acting as an array of vertically polarized monopoles. On the bottom layer an array of horizontally polarized dipoles are fed using microstrip lines. The two middle layers act as ground. Simulations show very good performance in the 27 to 29.5GHz range. In this frequency range, the horizontally and vertically polarized arrays provide better than –1.5dB efficiency, and higher than 11.5dBi realized gain. Also, the reflection coefficient is mostly below –10dB in the 27 to 29.5GHz range for each individual antenna element. Beam-steering is possible up to ± 35° for both polarizations with a scan loss below 3dB.
A 915 MHz Wristwatch-Integrated Antenna for Wireless Health Monitoring

A compact 915 MHz antenna integrated within a wristwatch wireless sensor device is presented. The antenna is a variant of a planar inverted-F antenna (PIFA) and uses a dual-resonator configuration. The results of simulation and measurement are shown to be in good agreement with the antenna exhibiting desirable impedance and radiation characteristics together with low Specific Absorption Rate (SAR) performance. The antenna is fabricated using a low cost flexible printed circuit and is fully integrated into the watch device. Measurements on the prototype antenna show a –10 dB impedance bandwidth of 30 MHz, a peak realized gain of –4.9 dBi and a peak radiation efficiency of 15.9% at 915 MHz. The antenna also has a low SAR value of 0.003 W/kg making it suitable for a wide range of wrist-worn wireless applications.
Dual-band Dual-polarized Antenna for mm-Wave 5G Base Station Antenna Array

A dual-band dual-polarized antenna suitable for 5G millimeter-wave base station antenna array is presented in this paper. It operates on all the commercial millimeter wave frequencies allotted in 5G NR from 24.25 GHz up to 40 GHz. The antenna is based on a novel stacked square ring patches arrangement to achieve wide dual band and stable radiation pattern. The antenna offers a sharp roll-off and a filter like response between the operating bands due to the strongly coupled resonators. Antenna design principle and simulated performance are discussed in detail. The -10 dB impedance bandwidth of the lower band starts from 24.25 GHz to 29.5 GHz while the higher band covers the 37 GHz to 40 GHz. The realized gain remains stable between 5 to 6 dBi at all the operating frequencies. The isolation between the ports and cross-polar discrimination remain better than 20 dB in all the covered frequency range.
The Use of Essential Oil and Hydrosol Extracted from Satureja hellenica for the Control of Meloidogyne incognita and M. javanica

Essential oil (EO) and hydrosol (HL) isolated from an indigenous plant species Satureja hellenica were evaluated against Meloidogyne incognita and M. javanica. Particularly, the activity of extracts on a second stage juvenile’s (J2s) motility, the hatching of J2s from eggs, egg differentiation and the effect on J2s in soil were tested. A paralysis of 100% of the J2s of both species was recorded after 96 h of immersion in the essential oil, at a dose of 2000 μL/L. At the same dose, the percentage of paralyzed J2s after 48 h of immersion was more than 80%, for both Meloidogyne species. The use of hydrosol has shown encouraging results only in the dilution of 50%, where for both Meloidogyne species tested, the percentage of paralyzed J2s was more than 70% after 48 h of immersion, while the percentage was increased to 90% after 96 h of immersion. Egg differentiation was ceased after immersion, either in EO or HL. However, this decrease in egg differentiation was evident only at higher concentrations of EO and at the highest HL dilution (0.5 v/v). The hatching of M. incognita J2s was decreasing as the dose was increasing. The lowest numbers of hatched J2s were recorded at the doses of 2000 and 4000 μL/L. A clear reduction in M. javanica J2s hatching was observed as the dose was increased to 250 μL/L, a fact constantly observed as the dose was increasing up to 4000 μL/L. Lower numbers of nematodes were recorded in roots grown in infested soil after the application of EO or HL at the highest doses. The EO of S. hellenica is characterized by the presence of p-cymene (27.46%) and carvacrol (23.25%), and in a lesser extent of other constituents, such as borneol (6.79%), carvacrol methylether (6.77%), γ-terpinene (4.63%) and 4-terpineol (3.65%). Carvacrol was the major constituent found in the HL (50.12%), followed by borneol and 4-terpineol (20.42 and 6.72%, respectively).
Avaliação de diferentes protocolos de extração de DNA para detecção de Brucella abortus a partir de diferentes tecidos de vacas infectadas experimentalmente com a cepa 2308

VEJARANO RUIBAL, M Del P. Evaluation of different protocols of DNA extraction for Brucella abortus detection from different tissues from experimentally infected cows with 2308 strain. [Avaliacao de diferentes protocolos de extracao de DNA para deteccao de Brucella abortus a partir de diferentes tecidos de vacas infectadas experimentalmente com a cepa 2308]. 2009. 79 f. Dissertacao (Mestrado em Medicina Veterinaria) – Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Sao Paulo, 2009. This study compared the performance of four protocols of DNA extraction from suspensions of different tissues from experimentally infected cows with 2308 strain. The compared extraction protocols were GT protocol (lyse with guanidine isotiocianate), Boom (lyse with GT and treated with the carrying suspension Diatomaceous earth), PK (lise with proteinase K) and Santos (lyse by boiling and freezing with liquid nitrogen). Based on classical bacteriology, positive and negative gold standard groups were built and consisted of 54 cotyledons (27 pos. and 27 neg.), 39 supramammary lymph nodes (12 pos. and 27 neg.), 44 prescapulars (17 pos. and 27 neg.), 33 livers (6 pos. and 27 neg.), 37 spleens (10 pos. and 27 neg.), and 34 udders (7 pos. and 27 neg.). All the samples were submitted to the four DNA extraction protocols and the same amplification process using the primers B4 and B5. According to consolidated results by tissue, the proportion of positives in cotyledon was bigger than supramammary lymph node (p=0,0001), prescapular lymph node (p<0,0001), liver (p=0,0006), spleen (p<0,0001) and udder (p=0,0019). The consolidated results for the extraction methods show that Santos protocol had bigger relative sensitivity than Boom method (p=0,003) and GT (p=0,0506), and was equal than PK (p=0,2969). There were not significant statistical differences in the others comparisons of proportions. In the study, PCRpositive and isolation-negative samples and vice-versa were verified. However, the disadvantages of the classic bacteriological method, the best strategy for direct diagnosis of the infection of cows for B. abortus in homogenized of tissues is combined use of isolation and PCR, examining the cotyledons and using the methods of DNA extraction from Santos or PK.
Comparing predicted yield and yield stability of willow and Miscanthus across Denmark

To achieve the goals of energy security and climate change mitigation in Denmark and the EU, an expansion of national production of bioenergy crops is needed. Temporal and spatial variation of yields of willow and Miscanthus is not known for Denmark because of a limited number of field trial data. The semi‐mechanistic crop model BioCro was used to simulate the production of both short‐rotation coppice (SRC) willow and Miscanthus across Denmark. Predictions were made from high spatial resolution soil data and weather records across this area for 1990–2010. The potential average, rain‐fed mean yield was 12.1 Mg DM ha−1 yr−1 for willow and 10.2 Mg DM ha−1 yr−1 for Miscanthus. Coefficient of variation as a measure for yield stability was poorest on the sandy soils of northern and western Jutland, and the year‐to‐year variation in yield was greatest on these soils. Willow was predicted to outyield Miscanthus on poor, sandy soils, whereas Miscanthus was higher yielding on clay‐rich soils. The major driver of yield in both crops was variation in soil moisture, with radiation and precipitation exerting less influence. This is the first time these two major feedstocks for northern Europe have been compared within a single modeling framework and providing an important new tool for decision‐making in selection of feedstocks for emerging bioenergy systems.
A AMC Substrate Backed Gain Enhanced Multi-Band Wearable Yagi Antenna

This paper proposes a modified Yagi-Uda antenna with multiple bands and increased gain for wearable applications. The proposed design consists of a coplanar fed microstrip Yagi antenna backed by an AMC substrate and a ground plane which shows an effective triple operational bandwidth. The AMC is designed to operate at triple bands of 3.4 GHz, 7.1 GHz and 9.5 GHz and the performance comparisons are carried out with and without using AMC substrate. The AMC layer comprises 2 ×3 unit cells to form the back plane reflector for Yagi antenna. The proposed antenna exhibits 2.6%, 2.5% and 5.42% low impedance bandwidths at 3.84 GHz, 4.31 GHz and 6.02 GHz frequency regions, respectively. The overall gain enhancement of about 5 dBi is achieved and shows endfire characteristics. The proposed antenna with high gain is a potential candidate for RFID, defence and, several medical applications.
Global change and eutrophication of coastal waters

Rabalais, N. N. , Turner, R. E. , Diaz, R. J., and Justic, D. 2009. Global change and eutrophication of coastal waters. - ICES Journal of Marine Science, 66: 1528-1537.The cumulative effects of global change, including climate change, increased population, and more intense industrialization and agribusiness, will likely continue and intensify the course of eutrophication in estuarine and coastal waters. As a result, the symptoms of eutrophication, such as noxious and harmful algal blooms, reduced water quality, loss of habitat and natural resources, and severity of hypoxia (oxygen depletion) and its extent in estuaries and coastal waters will increase. Global climate changes will likely result in higher water temperatures, stronger stratification, and increased inflows of freshwater and nutrients to coastal waters in many areas of the globe. Both past experience and model forecasts suggest that these changes will result in enhanced primary production, higher phytoplankton and macroalgal standing stocks, and more frequent or severe hypoxia. The negative consequences of increased nutrient loading and stratification may be partly, but only temporarily, compensated by stronger or more frequent tropical storm activity in low and mid-latitudes. In anticipation of the negative effects of global change, nutrient loadings to coastal waters need to be reduced now, so that further water quality degradation is prevented.
New Species of the Hyla albofrenata Group, from the States of Rio de Janeiro and São Paulo, Brazil (Anura, Hylidae)

Abstract Herein is described a new species of hylid frog from low elevations in the Atlantic Rain Forest, along the southern coast of the State of Rio de Janeiro and northern coast of the State of São Paulo, Brazil. The larvae and the site of reproduction are also described. It is a medium-sized species of the genus Hyla and is included in the Hyla albofrenata group by virtue of having lime green color of the body, orange-red iris without bicolored ring, voices sounding like drops of water falling into an empty bottle, and inhabiting mountain stream forests. The new species is very similar to Hyla albofrenata, from which it can be separated by its smaller size, larger calcar, length of the femur and tibia larger than the snout–vent length (SVL), by the clear coloration of the iris, morphology and coloration of the tadpole, and geographic distribution. The new species is also similar to Hyla ehrhardti from which it can be separated by having longer legs, presence of the calcar developed, presence of a supra-anal crest, color of the iris and northern distribution. It can be easily distinguished from Hyla arildae, Hyla musica, and Hyla weygoldti by possessing a curved and short supratympanic fold, by having a well-developed calcar and by its smaller SVL.