Miracle-dz/UniFAR-FTUs huggingface dataset:
Biodegradable magnesium alloy with eddy thermal effect for effective and accurate magnetic hyperthermia ablation of tumors

Abstract Magnetic hyperthermia therapy (MHT) is able to ablate tumors using an alternating magnetic field (AMF) to heat up magnetocaloric agents (e.g. magnetic nanoparticles) administered into the tumors. For clinical applications, there is still a demand to find new magnetocaloric agents with strong AMF-induced heating performance and excellent biocompatibility. As a kind of biocompatible and biodegradable material, magnesium (Mg) and its alloys have been extensively used in the clinic as an implant metal. Herein, we discovered that the eddy thermal effect of the magnesium alloy (MgA) could be employed for MHT to effectively ablate tumors. Under low-field-intensity AMFs, MgA rods could be rapidly heated, resulting in a temperature increase in nearby tissues. Such AMF-induced eddy thermal heating of MgA could not only be used to kill tumor cells in vitro, but also be employed for effective and accurate ablation of tumors in vivo. In addition to killing tumors in mice, we further demonstrated that VX2 tumors of much larger sizes growing in rabbits after implantation of MgA rods could also be eliminated after exposure to an AMF, illustrating the ability of MgA-based MHT to kill large-sized tumors. Moreover, the implanted MgA rods showed excellent biocompatibility and ∼20% of their mass was degraded within three months. Our work thus discovered for the first time that non-magnetic biodegradable MgA, an extensively used implant metal in clinic, could be used for effective magnetic thermal ablation of tumors under a low-field-intensity AMF. Such a strategy could be readily translated into clinical use.
Perspectives of Australian higher education leadership: convergent or divergent views and implications for the future?

ABSTRACT Leadership matters for the success of large enterprises and this is also the case for higher education institutions and universities. Yet, the public nature of universities and of academia means these institutions are usually highly dependent on external actors, in particular government. Viewed through a lens of distributed leadership, this paper explores how leaders in universities, national academies and government view and rate key changes associated with this pervasive reorientation and reorganisation of public higher education. It asks where do the views of leaders within universities and those outside universities converge and diverge and what patterns are evident in the differences between leaders? Drawing on 116 in-depth interviews and 114 follow-up surveys with senior higher education leaders in Australia, of which just over half were university senior executives, this paper concludes that all leaders surveyed are largely aligned in their views of most issues.
Field enhancement assisted graphene‐based microring modulator for high modulation depth

This study aims at optimising the graphene coverage in a microresonator for the design of an efficient modulator by using a combination of graphene induced losses and phase shift. The graphene integration in the ring can provide tunability by means of altering the loss and coupling coefficient by changing the graphene coverage or its chemical potential. The fundamental parameters of graphene integrated all-pass ring resonator are extracted based on the transmission characteristics using finite-difference time-domain method. As compared to conventional graphene-oxide-semiconductor straight waveguide, graphene integrated on an all-pass ring resonator shows enhanced optical absorption and phase shift due to field enhancement factor. A modulator based on graphene tunable loss and phase shift is investigated taking into account the field enhancement factor. For 1.55 μm radiation and ring radius of 3.75 μm with 22% graphene coverage, a maximum modulation depth of 12.6 dB is demonstrated based on electrostatic control of graphene chemical potential. The proposed modulator can feature operational speed in the range of 10 GHz that is useful in a variety of electro-optic applications.
Investigation of the slow kinetics of the prostanoid ep3 receptor antagonists l-798106 and l-826266 on guinea-pig aorta

EP3 receptor antagonists are a recent addition to the prostanoid ligand armoury. We have examined the profiles of two such agents, L-798106 (([(2E)-N-[(5-bromo- 2-methoxyphenyl)-sulphonyl]-3-[2¢-(2-naphthyl-methyl)phenyl]acrylamide) and its 5¢-chloro analogue L-826266 (Belley et al., 2006). Muscle tension in isolated preparations of thoracic aorta and vas deferens (electrical-field stimulation) from Dunkin-Hartley male guinea-pigs (600 - 800 g) was recorded. EP3 agonism (17- phenyl PGE2 or ONO-AE-248) on aorta was measured under priming with phenylephrine (500 - 1500 nM). Selectivity of prostanoid ligands was confirmed using human recombinant prostanoid receptor FLIPR assays (co-transfection with chimeric G-protein cDNAs to allow activation of Ca2+flux / HEK-293 EBNA cells). L-798106 and L-826266 (50-1000 nM) slowly inhibited established contraction of the guinea-pig aorta to the primed EP3 agonist (incomplete at 60 min) in contrast to faster block on vas deferens. Exposure of aorta to antagonist for 3 h resulted in much greater block and parallel displacement of the EP3 agonist log concentrationresponse curve; pA2 value = 7.58 and 7.96 respectively. Phentolamine (100 nM) rapidly inhibited phenylephrine / EP3 agonist responses. The potent TP antagonist BMS-180291 (Ifetroban) also slowly blocked U-46619 contraction of the aorta at concentrations of 0.3-3 nM (pA2 = 9.76), whereas the less potent antagonists EP-045 and EP-092 had faster onsets. Studies on histamine H1 antagonists showed that doxepin (pA2 = 9.6), terfenadine (pA2 = 7.9) and astemizole (7.5) were slow to reach steady-state block, while (+)-chlorpheniramine (9.1) was faster and diphenhydramine (7.8) even faster. The slow kinetics of L-798106, L-826266, terfenadine and astemizole, which have modest affinities, may relate to their very high lipophilicity (clogP = 6.87, 7.39, 6.54 and 5.64 repectively; ChemAxon software). In contrast, the slow kinetics of BMS-180291 and doxepin (cLogP = 3.60 and 3.59) are probably a consequence of their high affinity for TP and H1 receptors respectively. Care is needed in using highly lipophiic EP3 antagonists to elucidate receptor involvement.
Defining And Exploiting The Cytosine Deaminase Activity Of Apobec3a On The Extended Epigenome

AID/APOBEC family cytosine deaminases canonically play crucial roles in immunity by converting cytosine to uracil in single-stranded DNA (ssDNA). Outside of this established physiological role, AID/APOBEC enzymes have also been implicated in the poorly-understood process of DNA demethylation through their proposed deamination of epigenetically-modified cytosine bases like 5-methylcytosine (mC) and 5-hydroxymethylcytosine (hmC). However, there has been no thorough biochemical characterization of AID/APOBEC activity on these substrates, or on the recently-discovered 5-formylcytosine (fC) and 5-carboxylcytosine (caC) to inform this proposed role. Here, we provide the first steady-state kinetic measurements of the most active family member–APOBEC3A(A3A)–against various natural and unnatural modified substrates using a novel, restriction enzyme-based deamination assay. We determined that A3A has poor activity against bulkier oxidized cytosines, such as hmC, fC, and caC, and therefore likely does not contribute substantially to active DNA demethylation via deamination of these bases. By contrast, A3A efficiently deaminates mC in a manner not fully explained by the steric discrimination observed with other AID/APOBEC family members. Because A3A exhibits enzymatic proficiency for C and mC but potently discriminates against ox-mCs in vitro, we hypothesized that we could leverage A3A’s biochemical properties to efficiently localize ox-mCs in the genome. We developed APOBEC-Coupled Epigenetic Sequencing (ACE-Seq) – a nondestructive alternative to bisulfite-based methods for base resolution localization of hmC. We first validated this A3A-based method on differentially-modified phage genomes to demonstrate efficient conversion of C/mC and protection of hmC on a genome scale. We next applied ACE-Seq to mouse embryonic stem cell DNA and found a striking correlation with published hmC data from bisulfite-based methods. We also sequenced sorted mouse glutamatergic neurons and, using >100-fold less, saw significant correlation with previously published TABSeq data from unsorted mouse cortex DNA. Finally, we demonstrate the applicability of nondestructive ACESeq to locus-specific analysis with longer (>1 kb) amplicons, which could permit clustering analyses on single reads from larger regions such as enhancers. Altogether, we propose ACE-Seq as a facile alternative to bisulfite-based hmC localization methods, especially for analyzing limiting DNA samples, such as those from small or transient cell populations. Degree Type Dissertation Degree Name Doctor of Philosophy (PhD) Graduate Group Biochemistry & Molecular Biophysics First Advisor Rahul M. Kohli This dissertation is available at ScholarlyCommons: https://repository.upenn. edu/edissertations/2794
Análise morfométrica e caracterização geomorfológica da bacia hidrográfica do rio Jaboatão (BHRJ) – Pernambuco

The design and morphometric characterization of a hydrographic basin are fundamental elements of the dynamics of this environment, enabling contributions in the planning and management of water resources. The hydrographic basin of the Jaboatao River is located in the South Forest of the state of Pernambuco, included in the group of small coastal basins. For its morphometric characterization the theoretical precepts of Tonello (2005) and the methodological procedures of Christofoletti (1980) were used, while for the geomorphological mapping the proposal of Demek (1972) was applied. The products achieved in the morphometric analysis were segmented in three criteria: geometric, relief and drainage network, some main results were: area, perimeter, coefficient of compactness, slope, river hierarchy, drainage density and channel length. In the geomorphological characterization, three morphostructural units and six geomorphological units were mapped for the study area. The results obtained from the morphometric indices and the geomorphological mapping, enabled an integrated analysis of the geomorphological landscape of the Jaboatao river basin.
The Radial Forearm Free Flap: A Versatile Method for Head and Neck Reconstruction; Our Experience

Background: The radial free forearm flap (RFFF) was one of the first free tissue transfer flaps to be described. It has since become a work-horse for soft tissue replacement in head and neck cancer surgery, being commonly used to replace external skin and internal mucosal linings. Materials and Methods: This was a retrospective study on the reconstructions with microvascular radial forearm free flap in the head and neck area performed by physicians in the Head and Neck Service at our Hospital between June 2018 and January 2020. The aim of this study is to report our experience with radial forearm flap. Results: A total of 14 reconstructions with microvascularized free forearm free flap were carried out. Discussion: RFFF offers ease of harvesting and reliability due to its constant, reproducible vascular anatomy. It is also versatile owing to the relatively long pedicle and thin, pliable, hairless skin paddle. A two-team approach is possible in head and neck surgery, various forms being applicable, for example, free or pedicled, proximally or distally. Conclusion: The key points are careful flap and template design, flap design on the forearm to include the lateral intermuscular septum as well as a superficial vein (usually cephalic), elevate medial and lateral fasciocutaneous parts of the flap and dissect to-wards the lateral intermuscular septum and Brachioradialis muscle is most critical element of elevating the flap.
Pharmacokinetics under the COVID‐19 storm

The storm‐like nature of the health crises caused by COVID‐19 has led to unconventional clinical trial practices such as the relaxation of exclusion criteria. The question remains: how can we conduct diverse trials without exposing subgroups of populations to potentially harmful drug exposure levels? The aim of this study was to build a knowledge base of the effect of intrinsic/extrinsic factors on the disposition of several repurposed COVID‐19 drugs.
Kiai, Transformasi Pesantren dan Pencarian Model Gender Mainstreaming di Pesantren Subulussalam Tulungagung

Artikel ini berusaha mengungkap bagaimana peran kiai dapat dimaksimalkan untuk melakukan transformasi pesantren dengan menitikberatkan pada aspek keadilan gender di lingkungan pesantren. Teknik pengumpulan data melalui observasi, wawancara dan dokumentasi. Dengan metode deskriptif-partisipatoris, tulisan ini menunjukkan peran kiai sebagai sumber kebijakan yang memiliki implikasi langsung terhadap proses pengarusutamaan gender. Hal ini bertolakbelakang dengan pemahaman umum yang merujuk pada pandangan Geertz dimana Kiai sebagai penjaga tradisi dan konservatisme beragama, sulit untuk menerima perubahan. Namun saat ini, ditemukan berbagai upaya yang membuktikan argumentasi Dhofir terhadap Geertz, bahwa kiai dapat menjadi pusat inovasi di lingkungan pesantren yang secara signifikan. Melalui perencanaan dan pembiasaan, seluruh aktivitas yang melibatkan santri putra maupun putri di pesantren Subulussalam Tulungagung diupayakan untuk menunjukkan model gender mainstreaming, dimana keduanya memiliki hak dan kewajiban yang sama dalam menjalankan program pondok pesantren. Kerja sama tersebut untuk mengajarkan dengan santri bahwa kedudukan putra dan putri adalah setara baik dalam ruang publik maupun ruang domestik.
Psychometric Properties of the Body Image Acceptance and Action Questionnaire in Patients with Somatic Symptom and Related Disorders in Kashan City

Background: The Body Image Acceptance and Action Questionnaire (BI-AAQ) assesses cognitive flexibility and acceptance of body image. Objectives: This study was done to assess the validity and reliability of the Persian version of BI-AAQ, as an instrument to measure body image flexibility, in patients with somatic symptom and related disorders. Methods: This descriptive psychometric study was done in 2017 on 357 patients with somatic symptom and related disorders selected through a convenient sampling method from Kashan University of Medical Sciences clinics. They responded to the BI-AAQ, Depression, Anxiety, and Stress Scale (DASS), Acceptance and Action Questionnaire-II (AAQ-II), and Freiburg Mindfulness Inventory (FMI). The reliability of the BI-AAQ was calculated using Cronbach’s alpha coefficient. To assess its validity, the exploratory and confirmatory factor analyses were used. The gathered data were analyzed via SPSS-22 and Amos-22 software. Results: This version retained a one-factor structure, similar to the original version of the questionnaire, which explained 42.55% of the variance. It had high internal consistency (0.84), split-half method (0.77), and correlates with AAQ (0.45), mindfulness (0.39) and correlates contrastingly with stress (0.11), anxiety (0.36) and depression (0.43). Conclusions: According to the results of the current research, the BI-AAQ is a reliable instrument with valid psychometric properties to measure the body image acceptance of individuals in Iranian patients with somatic symptom and related disorders.
Deep emotion recognition based on audio-visual correlation

Human emotion recognition is studied by means of unimodal channels over the last decade. However, efforts continue to answer tempting questions about how variant modalities can complement each other. This study proposes a multimodal approach using three-dimensional (3D) convolutional neural networks (CNNs) to model human emotion through a modality-referenced system while investigating the solution to such questions. The proposed modality-referenced system selects the input data based on one of the modalities regarded as reference or master. The other modality which is referred to as a slave simply adjusts or attunes itself with the master in the temporal domain. In this context, the authors developed three multimodal emotion recognition system, namely, video-referenced system, audio-referenced system, and the audio–visual-referenced system to explore the congruence impact of audio and video modalities on each other. Two pipelines of 3D CNN architectures are employed where k-means clustering is used in the master pipeline and the slave pipeline adapts itself in a temporal sense. The outputs of the two pipelines are fused to improve recognition performance. In addition, canonical correlation analysis and t-distributed stochastic neighbour embedding is used validating the experiments. Results show that temporal alignment of the data between two modalities improves the recognition performance significantly.
Ants as predators of the Spinose Ear Tick, Otobius megnini (Dugès) in Sri Lanka

Many pathogens, parasitoids and predators have been documented as natural enemies of ticks, but their impact on tick populations are rarely evaluated. Here, we report the predatory behaviour of ants on the spinose ear tick, Otobius megnini. Ticks were collected from the ear canal of stabled horses in Nuwara Eliya and were brought to the laboratory. Eggs, unfed and engorged larvae, engorged nymphs and adults were naturally exposed to ants under laboratory conditions and the predatory behaviour of the different species and their feeding preferences were observed. Five ant species were found feeding on different life stages of O. megnini including eggs, larvae (fed/unfed) and adults; ants did not feed on the nymphal stages. Ant species were identified as Tapinoma melanocephalum, two species of Monomorium, one species of Pheidole and one species of Crematogaster. The predatory preference differed among the five ant species, with T. melanocephalum being identified as the best predator as it fed on eggs and adults, the non-parasitic stages of O. megnini. Different strategies have been used to control the infestations of O. megnini in the stabled horses but none of them were successful. Although we cannot extrapolate our empirical findings to a natural context, observations suggest that these ant species may be potential bio-suppressors of this tick species.
Current recommendations for the treatment of rhinosinusitis. Role of cefuroxime axetil

Rhinosinusitis is among the most prevalent respiratory infections occurring both in children and adults. The disease characteristically presents with nasal obstruction and discharge, pain or pressure and tenderness in the face, decreased sense of smell, and coughing. Based on the duration of symptoms, the type of nasal secretion, and the natural course of the disease, it can be classified into three types: acute viral rhinosinusitis, acute post-viral rhinosinusitis, and bacterial rhinosinusitis. Recommended non-pharmacological interventions in affected patients include maintaining adequate hydration and ensuring access to fresh moist air. Patients can also benefit from symptomatic therapy with antipyretics, anti-inflammatory agents, analgesics, mucosal decongestants and anti-secretion agents. Antibiotic treatment is indicated only for acute bacterial rhinosinusitis. In Poland, the first-line antibiotic therapy is based on high doses of amoxicillin. Second-line antibiotics include cefuroxime axetil, amoxicillin with clavulanic acid, and anti-pneumococcal fluoroquinolones. The treatment should last 10 days. Cefuroxime axetil is an effective and safe antibiotic in the treatment of patients with rhinosinusitis. The drug is used primarily when first-line therapy proves unsuccessful, and always in cases of non-immediate hypersensitivity reactions to penicillins. The development of symptoms indicative of sinusogenic, orbital or intracranial complications requires the initiation of systemic treatment in the hospital setting.
Magnetorheological method applied to optics polishing: A review

Magnetorheological finishing method is carried out in order to correct errors of figures which are produced by conventional polishing methods on planes, spheres, aspheres and freeform optics having surface roughness value as low as 1 nm RMS. Low surface roughness and mid-spatial frequencies in advanced optical systems are essential for minimizing flare and energy loss. Magnetorheological polishing fluid is a clever fluid that can alternate from its liquid phase to almost solid under magnetic field influence. The main key process parameters in magnetorheological finishing process such as fluid composition, rheological properties along with the surface quality of polished optical components (including metal, glass, and ceramic) are reviewed in the present manuscript.
Codependence : the influence of targeted soil inoculation on vegetative growth, chemical composition, and fruit fermentation

In order to ensure food security for the steadily increasing population, intensive, carefully managed agricultural practices are a necessity. In an attempt to increase crop yields, mineral and organic fertilizers have been excessively and incorrectly applied, resulting in problems for the neighbouring water systems. To avoid the environmental damages associated with excessive fertilizer application, other means of nutrient recycling and retention have been investigated. Biochar, a porous pyrogenic material, has been introduced to soil systems and has improved both the physical and chemical properties of the soil. Soil inoculation, or the addition of plant growth promoting bacteria, has been utilized with species specific results. The successful combination of these two techniques has produced a biocharmicrobial composite that has been applied to the soil with varying results on the vegetative growth of plants. An investigation into the volatile impact of the inoculation revealed that the volatile profile of marigold shoots changed, while the nitrogen uptake by a given plant was decreased or unaffected, depending on the plant species. In order to predict how these bacterial strains might behave in a fermentation environment, wine was co-fermented with yeast and bacteria. Common and predictable differences were observed in the LC-MS profiles of red and white wine when a bacterial strain was introduced to the fermentation. [April, 2018]
Rethinking Assessment in the 21st Century Senior High School (SHS) Social Studies Classroom in Ghana

 Introduction of Social Studies Education, University of Education, Winneba, Ghana Abstract: An emerging vision of educational assessment in this era is that of a dynamic process that continuously provides information with regard to learners’ progress and is generally geared towards achieving learning goals and the imbibitions of core competencies or survival skills in the learner. These competencies are but not limited to creativity and innovation, digital literacy, critical thinking and problem-solving, cultural identity and global citizenship, communication and collaboration, etc. This vision acknowledges that information collected as a result of student assessment is aligned to the curriculum goals. This is to ensure that data is appropriately used to inform instruction and justifies the fact that assessment is inseparable from teaching and learning. But the questions that emerge are: (1) How do Senior High School (SHS) Social Studies teachers in Ghana assess their learners and (2) For what purposes do SHS Social Studies teachers in Ghana assess their learners? As a qualitative meta-synthesis study, this paper sampled forty-four (4) works directly related to educational assessment but analysed in the context of Social Studies at the SHS level in Ghana. Sequel to this, the paper discusses the need for the adoption and use of alternative/authentic forms of assessment within the context of key debates in the field of educational assessment. It also examines the implications of the shift that is being called for in relation