Miracle-dz/UniFAR-FTUs huggingface dataset:
Surgical antibiotic prophylaxis use and infection prevalence in non-cosmetic breast surgery procedures at a tertiary hospital in Western Australia—a retrospective study

Background Surgical site infections (SSIs) are a common complication following breast surgery procedures, despite being considered a clean surgery. The prevalence of SSIs can be minimised with the appropriate use of antibiotic prophylaxis as outlined in the Australian Therapeutic Guidelines (eTG). The aims of this study were to evaluate adherence to the eTG for antibiotic prophylaxis in breast surgery procedures at a Western Australian teaching hospital following an update of the guidelines in 2014 and examine the impact of prophylactic antibiotics on SSI incidence and length of hospital stay. Method A retrospective cross-sectional study which reviewed medical records from a random sample of 250 patients selected from 973 patients who underwent breast surgical procedures between February 2015 and March 2017. Results Overall adherence to current eTG occurred in 49.2% (123/250) of operations. Pre-operative and post-operative antibiotics were prescribed in 98.4% (246/250) and 11.2% (28/250) operations respectively. Adherence rates to three specific elements of the eTG (drug prescribed, drug dosage and timing of administration) were 91.6% (229/250), 53.6% (134/250) and 86.4% (216/250) respectively. For the 14.4% (36/250) patients with relevant drug allergies, there was zero adherence to the eTG. Overall recorded SSI prevalence was low at 5.2% (13/250). The mean length of stay in patients (2.3 ± 1.7 days) was not influenced by level of eTG adherence (p = 0.131) or SSIs (p = 0.306). Conclusion These data demonstrate a significant improvement in overall adherence to the eTG from 13.3% to 49.2% (p = < 0.001). The level of detected SSIs in this study was low. Further improvement is necessary with respect to prescribing appropriate antibiotic dosages and for those with allergies.
At face value: Psychological outcomes differ for real vs. computer-generated multiracial faces

ABSTRACT Multiracial research emphasizes hypodescent categorizations and relies on computer-generated stimuli. Four experiments showed that real biracial faces in a 2-Choice categorization task (White, Black) elicited hypodescent more than computer-generated faces. Additionally, Experiment 2 showed a 2-Choice categorization task with real biracial faces increased racial essentialism more than a 3-Choice categorization task. Experiment 3 showed that mere exposure to real biracial faces did not increase essentialism. Finally, Experiments 4a and 4b replicated hypodescent outcomes when comparing real biracial faces to computer-generated versions of those same faces. In sum, these findings initiate a discussion surrounding the methodology of multiracial categorizations.
Relation between blood pressure and pulse wave velocity for human arteries

Significance Continuous, cuffless, and noninvasive blood pressure monitoring by measuring the pulse wave velocity is generally considered to be a promising technique for noninvasive measurements. Previously reported relations between blood pressure and pulse wave velocity relation involve unrealistic assumptions that do not hold for human arteries, and also rely on empirical expressions without any theoretical basis. Here, an analytical model without such assumptions or empirical expressions is established to yield a relation between blood pressure and pulse wave velocity that has general utility for future work in continuous, cuffless, and noninvasive blood pressure monitoring. Continuous monitoring of blood pressure, an essential measure of health status, typically requires complex, costly, and invasive techniques that can expose patients to risks of complications. Continuous, cuffless, and noninvasive blood pressure monitoring methods that correlate measured pulse wave velocity (PWV) to the blood pressure via the Moens−Korteweg (MK) and Hughes Equations, offer promising alternatives. The MK Equation, however, involves two assumptions that do not hold for human arteries, and the Hughes Equation is empirical, without any theoretical basis. The results presented here establish a relation between the blood pressure P and PWV that does not rely on the Hughes Equation nor on the assumptions used in the MK Equation. This relation degenerates to the MK Equation under extremely low blood pressures, and it accurately captures the results of in vitro experiments using artificial blood vessels at comparatively high pressures. For human arteries, which are well characterized by the Fung hyperelastic model, a simple formula between P and PWV is established within the range of human blood pressures. This formula is validated by literature data as well as by experiments on human subjects, with applicability in the determination of blood pressure from PWV in continuous, cuffless, and noninvasive blood pressure monitoring systems.
Examining symptom trajectories that predict worse outcomes in post-CABG patients

Background: Coronary artery bypass grafting is one of the most common interventional revascularisation procedures used to treat coronary artery disease worldwide. With a wide variability in postoperative cardiac symptoms, identification of symptom trajectories during the 3-month postoperative recovery period may improve clinicians’ abilities to support symptom recovery. Aims: To identify distinct trajectories of cardiac symptoms seen over time in a cohort of patients during the 3-month post-coronary artery bypass grafting period, and determine clinical characteristics associated with different symptom trajectories postoperatively. Methods: A prospective trial used the cardiac symptom survey to determine patient symptoms at baseline prior to surgery, and at 1 week, 6 weeks and 3 months following coronary artery bypass grafting. A latent class growth model and multivariate logistic regression analyses were used. Results: Data were obtained from patients (N=198) undergoing coronary artery bypass grafting in six medical centres of Taiwan, through patient medical records and interviews. Based on their frequency, trajectories were explored for the six most common postoperative symptoms including angina, dyspnoea, fatigue, depression, sleep problems and anxiety. We identified two to three distinct classes of trajectories for each symptom. Age, longer intensive care unit stay, fewer vessels bypassed, off-pump coronary artery bypass grafting, smoking history and lack of regular exercise were associated with worse symptom outcome trends over time. Conclusions: Using this unique trajectories-based research method, we are able to achieve a better understanding of symptom recovery patterns over time among coronary artery bypass grafting patients. Recognising risk factors and potential recovery patterns prior to surgery may allow healthcare providers to deliver targeted discharge planning and individualised care after coronary artery bypass grafting.
Juego serio para entrenar habilidades auditivas en niños con discapacidad auditiva

En este trabajo se presenta el diseño de un juego serio, cuyo objetivo es ejercitar la identificación y la discriminación auditiva en niños con discapacidades auditivas, tanto en aquellos que utilizan implantes cocleares como audífonos. En el diseño se han tenido en cuenta aspectos de diseño emocional, metodologías de desarrollo de juegos serios y las actividades que llevan a cabo los educadores con los niños para trabajar estas habilidades auditivas. Palabras clave: Niños; Discapacidad auditiva; Discriminación e identificación auditiva; Educación; Diseño; Juego Serio.
Predictor-Corrector Policy Optimization

We present a predictor-corrector framework, called PicCoLO, that can transform a first-order model-free reinforcement or imitation learning algorithm into a new hybrid method that leverages predictive models to accelerate policy learning. The new "PicCoLOed" algorithm optimizes a policy by recursively repeating two steps: In the Prediction Step, the learner uses a model to predict the unseen future gradient and then applies the predicted estimate to update the policy; in the Correction Step, the learner runs the updated policy in the environment, receives the true gradient, and then corrects the policy using the gradient error. Unlike previous algorithms, PicCoLO corrects for the mistakes of using imperfect predicted gradients and hence does not suffer from model bias. The development of PicCoLO is made possible by a novel reduction from predictable online learning to adversarial online learning, which provides a systematic way to modify existing first-order algorithms to achieve the optimal regret with respect to predictable information. We show, in both theory and simulation, that the convergence rate of several first-order model-free algorithms can be improved by PicCoLO.
ClickShield: Are You Hiding Something? Towards Eradicating Clickjacking on Android

In the context of mobile-based user-interface (UI) attacks, the common belief is that clickjacking is a solved problem. On the contrary, this paper shows that clickjacking is still an open problem for mobile devices. In fact, all known academic and industry solutions are either not effective or not applicable in the real-world for backward compatibility reasons. This work shows that, as a consequence, even popular and sensitive apps like Google Play Store remain, to date, completely unprotected from clickjacking attacks. After gathering insights into how apps use the user interface, this work performs a systematic exploration of the design space for an effective and practical protection against clickjacking attacks. We then use this exploration to guide the design of ClickShield, a new defensive mechanism. To address backward compatibility issues, our design allows for overlays to cover the screen, and we employ image analysis techniques to determine whether the user could be confused. We have implemented a prototype and we have tested it against ClickBench, a newly developed benchmark specifically tailored to stress-test clickjacking protection solutions. This dataset is constituted by 104 test cases, and it includes real-world and simulated benign and malicious examples that evaluate the system across a wide range of legitimate and attack scenarios. The results show that our system is able to address backward compatibility concerns, to detect all known attacks (including a never-seen-before real-world malware that was published after we have developed our solution), and it introduces a negligible overhead.
Scene Understanding Based on High-Order Potentials and Generative Adversarial Networks

Scene understanding is to predict a class label at each pixel of an image. In this study, we propose a semantic segmentation framework based on classic generative adversarial nets (GAN) to train a fully convolutional semantic segmentation model along with an adversarial network. To improve the consistency of the segmented image, the high-order potentials, instead of unary or pairwise potentials, are adopted. We realize the high-order potentials by substituting adversarial network for CRF model, which can continuously improve the consistency and details of the segmented semantic image until it cannot discriminate the segmented result from the ground truth. A number of experiments are conducted on PASCAL VOC 2012 and Cityscapes datasets, and the quantitative and qualitative assessments have shown the effectiveness of our proposed approach.
Female ornamentation and the fecundity trade‐off in a sex‐role reversed pipefish

Female ornaments are a rare occurrence in nature. One explanation for this is that female ornaments are costly to produce and maintain and, therefore, females must trade-off resources related to reproduction to promote ornament expression. Here, we investigate the potential trade-off between female ornamentation and fecundity in the sex-role reversed, wide-bodied pipefish, Stigmatopora nigra. We measured two components of the female ornament, body width and stripe thickness, and tested the relationship between these ornaments and female fecundity and the mean egg size. Both body width and stripe thickness were strongly and positively related to female body size. After controlling for the influence of body size, we found no evidence of a cost of belly width or stripe thickness on female fecundity. Rather, females that have larger ornaments have higher fecundity and thus a greater relative fitness advantage. However, larger females suffered a slight decrease in egg size, consistent with a potential trade-off between egg size and body size, although no relationship between egg size and ornaments was observed. Our results suggest that larger S. nigra females accurately advertise their reproductive value to males, and underscore the importance of investigating the potential mechanisms that promote and maintain honesty of female ornaments.
Thinking Outside the Box (and Arrow): Current Themes in Striatal Dysfunction in Movement Disorders

The basal ganglia are an intricately connected assembly of subcortical nuclei, forming the core of an adaptive network connecting cortical and thalamic circuits. For nearly three decades, researchers and medical practitioners have conceptualized how the basal ganglia circuit works, and how its pathology underlies motor disorders such as Parkinson’s and Huntington’s diseases, using what is often referred to as the “box-and-arrow model”: a circuit diagram showing the broad strokes of basal ganglia connectivity and the pathological increases and decreases in the weights of specific connections that occur in disease. While this model still has great utility and has led to groundbreaking strategies to treat motor disorders, our evolving knowledge of basal ganglia function has made it clear that this classic model has several shortcomings that severely limit its predictive and descriptive abilities. In this review, we will focus on the striatum, the main input nucleus of the basal ganglia. We describe recent advances in our understanding of the rich microcircuitry and plastic capabilities of the striatum, factors not captured by the original box-and-arrow model, and provide examples of how such advances inform our current understanding of the circuit pathologies underlying motor disorders.
Phenotypic plasticity of polyploid plant species promotes transgressive behaviour in their hybrids

Abstract Hybridization is a frequent process that leads to relevant evolutionary consequences, but there is a lack of studies regarding the relationships of the variability of the response of parental plant species to environmental gradients and the responses of their hybrids at a phenotypic level. We designed an experiment in which we exposed two reciprocal cordgrass hybrids, Spartina maritima × densiflora and S. densiflora × maritima, and their parental species to four salinity concentrations for 30 days. The main objectives were to compare the performance of the hybrids with that of their parents, to distinguish the phenotypic inheritance operating in the hybrids and to analyse the relationships between the variability in the responses of the parents and the responses of their hybrids to salinity. We characterized the responses and the degree of variability for 37 foliar traits. Both hybrids presented greater salinity tolerance than their parents, showing their highest percentage of transgressive traits at both extremes of the salinity gradient. When the parental plants themselves showed a more plastic response for a given trait, there was a greater chance that their hybrid developed a transgressive behaviour for this trait. This finding supports a new focus to be applied for the artificial development of vigorous hybrid crops.
Genetic loci determining total immunoglobulin E levels from birth through adulthood

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The biosynthesis of pyoverdines

Pyoverdines are fluorescent siderophores of pseudomonads that play important roles for growth under iron-limiting conditions. The production of pyoverdines by fluorescent pseudomonads permits their colonization of hosts ranging from humans to plants. Prominent examples include pathogenic or non-pathogenic species such as Pseudomonas aeruginosa, P. putida, P. syringae, or P. fluorescens. Many distinct pyoverdines have been identified, all of which have a dihydroxyquinoline fluorophore in common, derived from oxidative cyclizations of non-ribosomal peptides. These serve as precursor of pyoverdines and are commonly known as ferribactins. Ferribactins of distinct species or even strains often differ in their sequence, resulting in a large variety of pyoverdines. However, synthesis of all ferribactins begins with an L-Glu/D-Tyr/L-Dab sequence, and the fluorophore is generated from the D-Tyr/L-Dab residues. In addition, the initial L-Glu residue is modified to various acids and amides that are responsible for the range of distinguishable pyoverdines in individual strains. While ferribactin synthesis is a cytoplasmic process, the maturation to the fluorescent pyoverdine as well as the tailoring of the initial glutamate are exclusively periplasmic processes that have been a mystery until recently. Here we review the current knowledge of pyoverdine biosynthesis with a focus on the recent advancements regarding the periplasmic maturation and tailoring reactions.
Optical Fibre-Based Pulse Oximetry Sensor with Contact Force Detection

A novel optical sensor probe combining monitoring of blood oxygen saturation (SpO2) with contact pressure is presented. This is beneficial as contact pressure is known to affect SpO2 measurement. The sensor consists of three plastic optical fibres (POF) used to deliver and collect light for pulse oximetry, and a fibre Bragg grating (FBG) sensor to measure contact pressure. All optical fibres are housed in a biocompatible epoxy patch which serves two purposes: (i) to reduce motion artefacts in the photoplethysmogram (PPG), and (ii) to transduce transverse loading into an axial strain in the FBG. Test results show that using a combination of pressure measuring FBG with a reference FBG, reliable results are possible with low hysteresis which are relatively immune to the effects of temperature. The sensor is used to measure the SpO2 of ten volunteers under different contact pressures with perfusion and skewness indices applied to assess the quality of the PPG. The study revealed that the contact force ranging from 5 to 15 kPa provides errors of <2%. The combined probe has the potential to improve the reliability of reflectance oximeters. In particular, in wearable technology, the probe should find use in optimising the fitting of garments incorporating this technology.
Exertional Desaturation and Prescription of Ambulatory Oxygen Therapy in Interstitial Lung Disease

BACKGROUND: Exertional desaturation is an important predictor of mortality in patients with interstitial lung disease. We evaluated the prevalence of exertional desaturation in subjects with interstitial lung disease and determined its relationship with the prescription of ambulatory oxygen therapy. METHODS: Our retrospective analysis examined prospectively collected data from interstitial lung disease registries of 2 Melbourne hospitals: Alfred Health and Austin Health. All patients with baseline the 6-min walk tests on room air were included. We evaluated the prescription of ambulatory oxygen therapy, up to 3 months after 6-min walk tests, among those with exertional desaturation. RESULTS: Of the 400 subjects, 214 (54%) had exertional desaturation. The prevalence of desaturation increased with the severity of lung function impairment (FVC measurement: 33% for > 75% predicted, 69% for 50–75% predicted, 86% for < 50% predicted; diffusing capacity of the lung for carbon monoxide measurement: 20% for > 55% predicted, 64% for 36–55% predicted, 93% for ≤ 35% predicted, P < .001 for both severity classifications). There was no difference in the prevalence of exertional desaturation among common disease subtypes (P = .17). Among the desaturators, 14 (7%) had resting hypoxemia and all were prescribed long-term oxygen therapy. Of the remaining 200 with exertional desaturation only, 58 (29%) were prescribed ambulatory oxygen therapy. Multiple logistic regression showed independent associations between the ambulatory oxygen therapy prescription and shorter 6-min walk distance (P < .001) as well as worse FVC (% predicted, P = .037). CONCLUSIONS: Exertional desaturation is common in subjects with interstitial lung disease. More severely impaired exercise capacity and worse lung function are associated with the prescription of ambulatory oxygen therapy in interstitial lung disease.
Repetitive levosimendan infusions for patients with advanced chronic heart failure in the vulnerable post‐discharge period

Hospitalization for acute heart failure (HF) is associated with a substantial morbidity burden and with associated healthcare costs and an increased mortality risk. However, few if any major medical innovations have been witnessed in this area in recent times. Levosimendan is a first‐in‐class calcium sensitizer and potassium channel opener indicated for the management of acute HF. Experience in several clinical studies has indicated that administration of intravenous levosimendan in intermittent cycles may reduce hospitalization and mortality rates in patients with advanced HF; however, none of those trials were designed or powered to give conclusive insights into that possibility. This paper describes the rationale and protocol of LeoDOR (levosimendan infusions for patients with advanced chronic heart failure), a randomized, double‐blind, placebo‐controlled, international, multicentre trial that will explore the efficacy and safety of intermittent levosimendan therapy, in addition to optimized standard therapy, in patients following hospitalization for acute HF. Salient features of LeoDOR include the use of two treatment regimens, in order to evaluate the effects of different schedules and doses of levosimendan during a 12 week treatment phase, and the use of a global rank primary endpoint, in which all patients are ranked across three hierarchical groups ranging from time to death or urgent heart transplantation or implantation of a ventricular assist device to time to rehospitalization and, lastly, time‐averaged proportional change in N‐terminal pro‐brain natriuretic peptide. Secondary endpoints include changes in HF symptoms and functional status at 14 weeks.
Towards a more efficient use of process and product traceability data for continuous improvement of industrial performances

Nowadays all industrial sectors are increasingly faced with the explosion in the amount of data. Therefore, it raises the question of the efficient use of this large amount of data. In this research work, we are concerned with process and product traceability data. In some sectors (e.g. pharmaceutical and agro-food), the collection and storage of these data are required. Beyond this constraint (regulatory and / or contractual), we are interested in the use of these data for continuous improvements of industrial performances. Two research axes were identified: product recall and responsiveness towards production hazards. For the first axis, a procedure for product recall exploiting traceability data will be propose. The development of detection and prognosis functions combining process and product data is envisaged for the second axis.