Miracle-dz/UniFAR-FTUs huggingface dataset:
Responsiveness to lipolytic hormones, and inactivation of adrenocorticotropin, by adipose tissue slices and free fat cells from different mammalian species.

The adipose tissues of rat, hamster and guinea pig are known to differ from each other in capacity to respond to the lipolytic action of adrenocorticotropin (ACTH), β-melanocyte-stimulating hormone (β-MSH), thyroidstimulating hormone (TSH), glucagon and epinephrine, and in capacity of the homogenized tissue, to destroy the lipolytic activity of ACTH and other lipolytic pituitary peptides. In order to learn whether these species differences reside in the fat cells, or in other components of the adipose tissue, (a) adipose tissue slices and free fat cells (prepared by the collagenase technique of Rodbell) from the same rat, hamster or guinea pig were incubated with ACTH, β-MSH, TSH, glucagon or epinephrine, and the lipolytic response was measured; (b) aqueous homogenates of adipose tissue and free fat cells from the same rat or hamster were incubated with ACTH and the effect of the incubation on the hormone’s lipolytic activity was measured. The data show that, in all 15 instances tested, the free fat cells.
The TIPSTER Text Program Overview

These TIPSTER Phase III Proceedings bring to a close a program that had significant impact on information technology. Since 1991, the TIPSTER Text program has fostered the advancement of state-of-the-art technologies for text handling through the efforts of researchers and developers in the U.S. Government, industry and academia. The resulting capabilities are being deployed throughout the intelligence community to provide analysts with improved information processing tools.
Reduction of mammary and liver lipogenesis and alteration of milk composition during lactation in rats by hypothyroidism.

OBJECTIVE The profound impairment in litter growth produced by untreated maternal hypothyroidism (HypoT) may be a consequence of maternal metabolic dysfunctions affecting lactation. In this work we studied the effects of HypoT on mammary and liver lipid metabolism and its consequences on milk quality. DESIGN We studied the effects of prolonged 6-propyl-2-thiouracil (PTU)-induced HypoT (0.01% PTU in drinking water starting 8 days before mating until sacrifice) on milk macronutrient composition, liver and mammary lipid metabolism and content and serum lipid, and glucose and insulin concentrations in rats on days 7, 15 (L15), and 20 (L20) of lactation. Mammary and hepatic mRNA abundances of lipogenic enzymes were measured using semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) on L15 and L20. MAIN OUTCOME Milk lactose and triglycerides (TG) were reduced by HypoT, as well as mammary acetyl CoA carboxylase (ACC) activity on L15 and L20, and ACC and lipoprotein lipase (LPL) mRNA on L20. HypoT also decreased hepatic ACC activity on both days, ACC mRNA on L15 and liver [(3)H]H(2)O incorporation to TGs and TG content on L20. HypoT diminished insulinemia, increased serum total lipids, and decreased serum TGs on some or all the days of lactation studied. CONCLUSION HypoT produces a drastic decrease in milk TGs; the main cause for this seems to be the decreases in liver TG synthesis and in circulating TGs, which, along with reduced mammary uptake of fatty acids caused by decreased LPL expression and possibly diminished mammary lipogenesis, result in an impaired mammary output of TGs to the milk. Thus, the impaired growth of the litters of HypoT mothers can be largely attributed to the low milk quality along with the impaired milk ejection.
Representations of Time Expressions for Temporal Relation Extraction with Convolutional Neural Networks

Token sequences are often used as the input for Convolutional Neural Networks (CNNs) in natural language processing. However, they might not be an ideal representation for time expressions, which are long, highly varied, and semantically complex. We describe a method for representing time expressions with single pseudo-tokens for CNNs. With this method, we establish a new state-of-the-art result for a clinical temporal relation extraction task.
Induction of reproducible brain infarction by photochemically initiated thrombosis

We have used a photochemical reaction in vivo to induce reprodcible thrombosis leading to cerebral infarction in rats. After the intravenous injection of rose bengal, a potent photosensitzing dye, an ischemic lesion was formed by irradiating the left parietal convexity of the exposed skull for 20 minutes with green light(560nm) from a filtered xenon arc lamp. Animals were allowed to surivive form 30 minutes to 15 days after irradiation. Early microscopic alerations within the irradiated zone included the formation of thrombotic plugs and adjacent red blood cell stasis within pial and parenchymal vessels. Scanning electron microscopy revealed frequent platelet aggregates adhering to the vascular endothelium, often resulting in vascular occlusion. Carbon‐black brain perfusion demonstrated that occlusion of vascular channels progressed after irradiation and was complete within 4 hours. Histopathological examination at 1, 5, and 15 days revealed that the associated infarct evolved reproducibly through several characteristic stages, including a phase of massive macrophage infiltration. Although cerbral infarction in this model is initiated by thrombosis of small bolld vessels, the fact that the main pathological features of stroke are consistently reproduced should permit its use in assessing treatment regimens, Further, the capability of producing infarction in preselected cortiacal regions may facilitate the study of behavioral, functional, and structural consequences of acute and chronic stroke.
The impact of organizational supply chain network on information system: An integrated approach toward information system formulation and improvement

In order to manage and control organizational information flow effectively, information system (IS) is developed to operate a collection of data structured according to the needs of a company. The paper proposes a framework showing how the organizational IS affect the organizational supply chain activities. This paper also proposes an integrated approach toward organizational IS formulation and improvements. Through using IT, the role of organizational information system is hoped to facilitate organizational users to handle the business problems they face, develop competitive advantage and seek future business opportunities.
Evaluation of Expression of Human Epidermal Growth Factor Receptor 2 (HER2) in Gastric and Gastroesophageal Junction Adenocarcinoma Using IHC and Dual-ISH.

BACKGROUND/AIM Trastuzumab® is used for human epidermal growth factor receptor 2 (HER2)-overexpressing metastatic gastric/gastroesophageal junction (GEJ) adenocarcinoma. Our aim was to compare HER2 expression by immunohistochemistry (IHC) and dual in situ hybridization (DISH) in early-stage vs. late-stage gastric and GEJ tumors. MATERIALS AND METHODS Fifty early-stage and 50 late-stage gastric tumors and a similar number of early-stage and late-stage GEJ tumors were studied. HER2 was analyzed by IHC and dual-ISH using tissue microarray. RESULTS Of 200 selected cases, 168 had satisfactory results. Among the 110 cases with both tests successfully performed, there were only five cases with discrepancy between assays (4.5%). Seven equivocal (2+) cases by IHC were all found to be amplified by dual-ISH. When compared with IHC, dual-ISH identified 12 additional HER2-positive cases (10.9%). CONCLUSION The 12.5% overall overexpression/amplification in gastric and GEJ adenocarcinomas is in concordance with previous reports. No correlation was found between tumor stage and HER2 overexpression/amplification. Determination of HER2 in limited tissue samples benefits from combinational IHC and ISH testing.
Security Analysis of Zigbee

This paper analyzes the security of Zigbee a wireless communication protocol for Internetof-Things devices. We start with the components in a network using Zigbee standard. We then give the readers an overview of the security policy, measures, and architecture. After the series of introductions of the standard, we discuss the devices and methods used to find security vulnerabilities and corresponding results. Lastly, we present a set of recommendations to Zigbee standard that will likely improve their security.
A security framework for reflective Java applications

The advent of component‐based reflective applications raises the issue of protecting baselevel components from the actions performed by metalevel components. However, by their very nature, reflective applications are far more difficult to secure than non‐reflective applications, which certainly explains why the problem has received very little attention so far. In this paper we present a security framework for enforcing access control between metalevel components and the baselevel components they reflect on. Rather than designing a new security architecture from scratch, we extend the standard security architecture of Java to provide security for a fully‐functional proxy‐based MOP for Java. We implement a number of well‐known meta‐level behaviors and study their security requirements, the results of which support our design choices. Copyright © 2003 John Wiley & Sons, Ltd.
Analysis on the risk factors of second fracture in osteoporosis-related fractures.

OBJECTIVE To explore the clinical characteristics and risk factors of refracture in patients suffering from osteoporosis-related fractures as well as effective interventions. METHODS From January 2006 to January 2008, both out-patients and in-patients in our hospital who were over 50 years old and suffered from osteoporosis-related fractures were selected for this research. They were divided into fracture group and refracture group. The refracture rate was followed up for 2 years, during which 11 patients developed refracture, thus were included in the refracture group. Therefore, 273 patients, 225 first-fracture cases, aged (67.7+/-8.5) years, and 48 refracture cases, aged (72.7+/-9.5) years, were included in this study. General data including age and sex, fracture types, femoral neck bone mineral density (BMD) T-scores tested by dual-energy X-rays absorptiometry (DEXA), Charlson index, time-frame between two fractures as well as mobility skill assessment were collected and analyzed by single-factor and multivariate statistical methods. RESULTS Females accounted for 70.2% of the fracture group and 77.1% of the refracture group. The most common refracture type was vertebral fracture for the first time and femoral neck fracture for the second time during the follow-up. The second fracture happened 3.7 years after the first one on average. The refracture rate was 2.12% within one year, and 4.66% within two years. Risk factors for a second fracture in osteoporotic fracture patients included age (larger than 75 years, HR equal to 1.23, 95%CI 1.18-1.29; larger than 85 years, HR equal to 1.68, 95% CI 1.60-1.76), female sex (HR equal to 1.36, 95%CI 1.32-1.40), prior vertebral fractures (HR equal to 1.62, 95%CI 1.01-2.07), prior hip fractures (HR equal to 1.27, 95%CI 0.89-2.42), BMD T-score less than -3.5 (HR equal to 1.38, 95%CI 1.17-1.72) and weakened motor skills (HR equal to 1.27, 95%CI 1.09-1.40). CONCLUSIONS The risks of second fracture among patients with initial brittle fracture are substantial. There is adequate time between the first and second fractures for interventions to reduce the risks of refracture, especially for the old women with a vertebral or hip fracture. Medication, motor functional rehabilitation and fall-down prevention training are helpful.
"Fluorescent timer": protein that changes color with time.

We generated a mutant of the red fluorescent protein drFP583. The mutant (E5) changes its fluorescence from green to red over time. The rate of color conversion is independent of protein concentration and therefore can be used to trace time-dependent expression. We used in vivo labeling with E5 to measure expression from the heat shock-dependent promoter in Caenorhabditis elegans and from the Otx-2 promoter in developing Xenopus embryos. Thus, E5 is a "fluorescent timer" that can be used to monitor both activation and down-regulation of target promoters on the whole-organism scale.
The Serpin-Enzyme Complex Receptor Recognizes Soluble, Nontoxic Amyloid-β Peptide but Not Aggregated, Cytotoxic Amyloid-β Peptide*

There is now extensive evidence that amyloid-β peptide is toxic to neurons and that its cytotoxic effects can be attributed to a domain corresponding to amyloid-β 25-35, GSNKGAIIGLM. We have shown recently that the serine proteinase inhibitor (serpin)-enzyme complex receptor (SEC-R), a receptor initially identified for binding of α1-antitrypsin (α1-AT) and other serine protease inhibitors, also recognizes the amyloid-β 25-35 domain. In fact, by recognizing the amyloid-β 25-35 domain, SEC-R mediates cell surface binding, internalization, and degradation of soluble amyloid-β peptide. In this study, we examined the possibility that SEC-R mediates the neurotoxic effect of amyloid-β peptide. A series of peptides based on the sequences of amyloid-β peptide and α1-AT was prepared soluble in dimethyl sulfoxide or insoluble in water and examined in assays for SEC-R binding, for cytotoxicity in neuronal PC12 cells and murine cortical neurons in primary culture, and for aggregation in sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis. The results show that amyloid-β peptide 25-35 and amyloid-β peptide 1-40 prepared soluble in dimethyl sulfoxide compete for binding to SEC-R, are nontoxic, and migrate as monomers in SDS-PAGE analysis. In contrast, the same peptides aged in water did not compete for binding to SEC-R but were toxic and migrated as aggregates in SDS-PAGE. An all-D-amyloid-β 25-35 peptide was not recognized at all by SEC-R but retained full toxic/aggregating properties. Using a series of deleted, substituted, and chimeric amβ/α1-AT peptides, toxicity correlated well with aggregation but poorly with SEC-R recognition. In a subclone of PC12 cells which developed resistance to the toxic effect of aggregated amyloid-β 25-35 there was a 2.5-3-fold increase in the number of SEC-R molecules/cell compared with the parent PC12 cell line. These data show that SEC-R does not mediate the cytotoxic effect of aggregated amyloid-β peptide. Rather, SEC-R could play a protective role by mediating clearance and catabolism of soluble, monomeric amyloid-β peptide, if soluble amyloid-β peptide proves to be an in vivo precursor of the insoluble, toxic peptide.
L'anaphore rhétorique dans le discours politique

L'article analyse l'anaphore rhetorique dans le discours politique. Le corpus d'etude est constitue des discours de campagne de N. Sarkozy. Apres avoir evalue les criteres definitionnels qui font de l'anaphore une figure structurante, les enjeux pragmatiques de cette derniere sont observes. Figure de structuration, d'amplification et d'assertivite, elle peut etre definie comme forme-sens signifiante dans un genre particulier. L'approche de l'anaphore rhetorique est renouvelee par cette analyse qui croise pragmatique, syntaxe mais aussi analyse quantitative.
Creating a Portable Programming Language Using Open Source Software

On a first glance, the field of compiler construction and programming language design may not seem to have experienced major innovations over the last decade. By now, it is almost common knowledge how a lexer works, how parsing is done, but not many have yet realized how Open Source software-and in particular the GNU Compiler Collection-have silently offered language implementors new and better ways to do their job. Therefore, this paper describes the novel advantages Open Source software provides and, furthermore, it illustrates these with practical examples showing how the presented concepts can be put into practice. Another important contribution of this paper is to give an overview over the existing limitations and the technical problems that can occur when creating an Open Source based programming language implementation.
Renal dysfunction in HNF 1 α / MODY 3 deficiency scientific reports

Unité des Virus Oncogènes, URA 1644 CNRS, Département des Biotechnologies, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris CEDEX 15, 1Unité des Transports Epithéliaux, U426 INSERM, Faculté de Médecine Xavier Bichat, 16, rue Henri Huchard, 75870 Paris CEDEX 18, 2Service des Explorations Fonctionnelles, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, 3Institut de Biologie de Lille, EP 10 CNRS, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille and 4Unité de Pathologie Métabolique et Hormonale du Developpement U342 INSERM, Hôpital Saint-Vincent-de-Paul, 82 Avenue Denfert Rochereau, 75014 Paris, France
In vivo imaging indicates muscle fiber dedifferentiation is a major contributor to the regenerating tail blastema.

During tail regeneration in urodele amphibians such as axolotls, all of the tissue types, including muscle, dermis, spinal cord, and cartilage, are regenerated. It is not known how this diversity of cell types is reformed with such precision. In particular, the number and variety of mature cell types in the remaining stump that contribute to the blastema is unclear. Using Nomarski imaging, we followed the process of regeneration in the larval axolotl tail. Combining this with in vivo fluorescent labeling of single muscle fibers, we show that mature muscle dedifferentiates. Muscle dedifferentiation occurs by the synchronous fragmentation of the multinucleate muscle fiber into mononucleate cells followed by rapid cell proliferation and the extension of cell processes. We further show that direct clipping of the muscle fiber and severe tissue damage around the fiber are both required to initiate dedifferentiation. Our observations also make it possible to estimate for the first time how many of the blastema cells arise specifically from muscle dedifferentiation. Calculations based on our data suggest that up to 29% of nondermal-derived cells in the blastema come from dedifferentiation of mature muscle fibers. Overall, these results show that endogenous multinucleate muscle fibers can dedifferentiate into mononucleate cells and contribute significantly to the blastema.
A Random Local Matroid Search Algorithm to Construct Good Rate  $1/p$ Systematic Binary Quasi-Cyclic Codes

In this letter, a random local matroid search algorithm is proposed to construct good rate 1/p systematic QC codes based on the relationship between the generator matrix and the minimum distance when the length of the information vector is k ≥ 15 . More than twenty new QC codes are obtained and their corresponding generator matrices are revealed, which extends previous results. Nine of these new codes have larger minimum distances than the reported ones in the previous literature.
EFECTO HEPATOPROTECTOR DEL GEL DE Aloe vera L. MODIFICADO FRENTE A LA INJURIA INDUCIDA EN RATONES CON ACEITE COMESTIBLE RECALENTADO MEZCLADO CON DMSO

El objetivo del presente estudio fue evaluar el efecto hepatoprotector del gel de Aloe vera modificado (GAVM) frente a la injuria inducida en ratones albinos por la administracion, via oral, de aceite comestible recalentado (ACR) mezclado con dimetilsulfoxido (DMSO) (1:1). Las dosis de ACR usadas fueron 2,3 y 3,1 mL/kg, administradas por 14 dias, lo cual produjo incremento de las transaminasas (ALT, AST) y trigliceridos. A los ejemplares que recibieron la menor dosis de ACR (2,3 mL/kg de peso), a partir del dia 14 y por 18 dias, se les suministro, adicionalmente, cuatro gotas diarias de GAVM equivalente a 6,1 mL/kg de peso. Al analizar los resultados obtenidos a los 14, 19, 28 y 33 dias de iniciado el tratamiento, se observo disminucion progresiva significativa de ALT, AST y trigliceridos. Sin embargo, los ejemplares que recibieron mayor dosis de ACR (3,1 mL/kg de peso) mas GAVM, presentaron incremento en los niveles de ALT, AST y trigliceridos conforme transcurrio el tiempo, sugiriendo que la peroxidacion lipidica y los radicales libres formados rebasan el efecto hepatoprotector del GAVM. Los niveles de proteinas no experimentaron variaciones significativas. Los ratones de tres grupos control no presentaron variaciones significativas en los indicadores bioquimicos estudiados, sin embargo, en el grupo control que recibio GAVM se observo disminucion de trigliceridos. En conclusion, el GAVM mostro efecto hepatoprotector ante una dosis 2,3 mL/kg de peso de ACR, no sucediendo lo mismo al aumentar el ACR (3,1 mL/kg de peso), ante lo cual la dosis de GAVM fue insuficiente.
Palmar and digital black pseudochromhidrosis: a case report

Colored sweat is an extremely rare disorder in the clinical practice. Chromhidrosis is characterized by the secretion of colored sweat. By contrast, pseudochromhidrosis refers to coloration of otherwise colorless sweat on the skin surface because of extrinsic agents such as chromogenic bacterial products, fungi, chemicals, paints, or dyes. Two glands produce sweat: eccrine and apocrine glands. Chromhidrosis is apocrin in origin, and eccrine chromhidrosis is very rare and occurs with the ingestion of certain drugs and dyes. In apocrine chromhidrosis, lipofucsins are found in a higher than normal concentration or a higher than normal state of oxidation in apocrine glands. Clinical history should include a detailed investigation of the patient’s environment and lifestyle to exclude exogenous causes. Few clinical cases of pseudochromhidrosis have been reported in the English literature. Eccrine pseudochromhidrosis has classically been reported in copper workers as blue sweat. Additionally, there were reports of flights attendants who experienced red discoloration of their sweat after wearing uniforms, which had been labeled with a red dye. Differential diagnosis between chromhidrosis and pseudochromhidrosis is very important to avoid unnecessary tests and therapies. Diagnosis of pseudochromhidrosis is based primarily on a detailed clinical history and in successful treatment with antibiotics. Contrarily, the diagnosis of chromhidrosis is based on cutaneous biopsy, and 562 (a)
Wnt pathway activation, cell migration, and lipid uptake is regulated by low-density lipoprotein receptor-related protein 5 in human macrophages.

AIMS Atherosclerosis plaque development includes infiltration of inflammatory cells, accumulation of lipids and fibrous cap formation. Low-density lipoprotein receptor-related protein 1 (LRP1) is expressed on atherosclerotic lesions associated with macrophages and vascular smooth muscle cells. The aim of this work is to analyse the role in atherosclerosis lesion progression of another member of the LDL receptor protein family, low-density lipoprotein receptor-related protein 5 (LRP5), a co-receptor with Frizzled known to activate the Wnt signalling pathway in several cell types. METHODS AND RESULTS LRP5 is expressed in human vascular and innate inflammatory cells. LRP5 is transcriptionally regulated by aggregated LDL (agLDL), participating in the lipid uptake and transformation of macrophages into foam cells, a critical step in atherosclerosis progression. AgLDL-treated macrophages show up-regulated expression of β-catenin, LEF1, c-jun, cyclinD1, bone morphogenetic protein 2 (BMP2), and osteopontin (OPN), proteins and targets of the Wnt signalling pathway, whereas LRP5-silenced macrophages show a significant down-regulation of OPN and BMP2 expression. Furthermore, LRP5-deficient macrophages exhibit an impaired migration both in wound-repair and modified Boyden chambers models. CONCLUSION These results demonstrate the involvement of LRP5 in the innate inflammatory reaction to lipid infiltration in atherosclerosis.