Miracle-dz/UniFAR-FTUs huggingface dataset:
Las Prácticas De Asesoramiento A Centros Educativos: Una Revisión Del Modelo De Proceso

Los procesos de cambio en los centros educativos son complejos y personales. Sobre ellos se han realizado muchas disertaciones y experiencias. Se han desarrollado multiples modelos de apoyo y estrategias de asesoramiento. Y hemos aprendido numerosas lecciones y paradojas de estas situaciones. Perdida la ingenuidad, hay que ir a lo fundamental: los contenidos y el propio proceso de (auto) reconstruccion. El articulo analiza las practicas de asesoramiento a centros educativos y presenta una revision critica del modelo de proceso desde los siguientes contenidos: (1) el proceso de asesoramiento en el viaje hacia la mejora (momentos, subprocesos y finalidades); (2) el proceso de asesoramiento no es una tecnologia sino una buena herramienta de trabajo; (3) y describe las lecciones aprendidas, las contradicciones a asumir y las precauciones a tomar en el proceso de asesoramiento.
GP struck off for fraud in drug trials

A general practitioner in Britain has been struck off after the professional conduct committee of the General Medical Council decided that he had entered patients for paid drug trials without their consent (see p.789) Dr Geoffrey Fairhurst, 57, a former government health adviser, practised in St Helens, Merseyside. Sir Donald Irvine, president of the GMC, expressed particular concern that Dr Fairhurst had served on a research ethics committee. Dr Fairhurst signed agreements to test various drugs including captopril, bumetanide, and lacidipine between 1988 and …
Fabrication of Phase-Shifted Long-Period Fiber Grating and Its Application to Strain Measurement

Several kinds of phase-shifted long-period gratings (LPGs) have been fabricated using a high-repetitionrate CO<sub>2</sub> laser, where both the grating and the inserted phase shift are simultaneously produced in a commonly used single-mode fiber. Furthermore, using one of the fabricated phase-shifted LPGs, a temperature-insensitive sensor that allows for large axial strain measurement with a value up to 7600 με, is proposed and first demonstrated. Measurement accuracy for the strain ranging from 340 to 7600 με is estimated to be ±30 με, while the temperature is changed in a range of 20°C-140°C.
Restorative effects of awe on negative affect after receiving negative performance feedback

The present study investigated the discrete positive effects of awe on negative job affect (NJA) arising from receiving negative performance feedback from a work supervisor or a co-worker. The participants were 131 business professionals and students at a large university in Kenya (females = 46%; age range 25 to 65 years). They participated in an experiment in which the emotion of awe was manipulated in an imagined situation where the participants received negative performance feedback from either a work supervisor or co-worker. Regression analyses of the data indicated that awe predicted a lower negative affect for negative feedback. Moreover, the indirect effects of the source of feedback on negative affect modulation were more significant for feedback received from co-workers than from supervisors. The positive emotion of awe may help one cope with negative performance feedback in a work setting.
Clinical impact of serum exosomal microRNA‐21 as a clinical biomarker in human esophageal squamous cell carcinoma

Exosomes are 40‐nm to 100‐nm membrane vesicles that are secreted by various cells, and they play a major role in cell‐cell communication. The objective of this study was to clarify the significance of the levels of microRNA in exosomes extracted from the sera of patients with esophageal squamous cell cancer (ESCC).
Evaluating Hydrologic Design under Stationary and Non-Stationary Assumptions

Author(s): Rivadeneira Vasquez, Juan Diego | Advisor(s): AghaKouchak, Amir | Abstract: In a warming climate, the magnitude and/or frequency of precipitation is expected to change in some regions, leading to higher local flood risk. This issue has raised much needed attention in the engineering design and flood management communities, and has motivated discussion on guidelines for improving infrastructure design in a changing climate. The existing infrastructure design concept assumes a stationary climate indicating no significant change in statistics of extremes over time. In a changing climate, however, frequency and severity of extreme events might change - a notion known as non-stationarity. Typically, a freeboard is included in hydrologic design as safety factor to improve infrastructure resilience, which might fail to deliver the intended level of reliability in a changing climate. This study considers 5 locations in the Northeastern United States that have shown a non-stationary behavior over time in the annual streamflow maxima. First, a freeboard is estimated based on the stationary assumption, commonly used for engineering design. The freeboard assuming a non-stationary climate is then evaluated against the commonly used stationary assumption. The Non-stationary Extreme Value Analysis (NEVA) software, which utilizes Extreme Value Theory (EVT) framework and Bayesian inference for parameter estimation, is used to obtain Return Level-Return Period curves under both stationary and non-stationary assumptions. The 100-year streamflow estimates under both stationary and non-stationary assumptions are used as input into HEC-RAS software to simulate the flow and compare the change in freeboard. Results show an expected increase in the magnitude of streamflow for 100-year events when there is a positive trend in observations. Under a non-stationary assumption, the freeboard decreases approximately 16% on average in our 5 case studies. This indicates that for a bridge design case study, there will be a higher chance of overtopping because the freeboard is less than the initial design under a stationary assumption. Potential changes in freeboard and, hence, failure risk in a warming climate calls for improved design concepts that consider potential changes in extremes over time. However, incorporating non-stationarity in design concepts is a challenging task, and requires not only model development but also an adaptation strategy.
Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer

Significance Unique among the large number of noncoding RNA species, the pericentromeric human satellite II (HSATII) repeat is massively expressed in a broad set of epithelial cancers but is nearly undetectable in normal tissues. Here, we show that deregulation of HSATII expression is tightly linked to growth under nonadherent conditions, and we uncover an unexpected mechanism by which HSATII RNA-derived DNA (rdDNA) leads to progressive elongation of pericentromeric regions in tumors. The remarkable specificity of HSATII overexpression in cancers, together with the consequences of targeting its RT, points to a potential novel vulnerability of cancer cells. Aberrant transcription of the pericentromeric human satellite II (HSATII) repeat is present in a wide variety of epithelial cancers. In deriving experimental systems to study its deregulation, we observed that HSATII expression is induced in colon cancer cells cultured as xenografts or under nonadherent conditions in vitro, but it is rapidly lost in standard 2D cultures. Unexpectedly, physiological induction of endogenous HSATII RNA, as well as introduction of synthetic HSATII transcripts, generated cDNA intermediates in the form of DNA/RNA hybrids. Single molecule sequencing of tumor xenografts showed that HSATII RNA-derived DNA (rdDNA) molecules are stably incorporated within pericentromeric loci. Suppression of RT activity using small molecule inhibitors reduced HSATII copy gain. Analysis of whole-genome sequencing data revealed that HSATII copy number gain is a common feature in primary human colon tumors and is associated with a lower overall survival. Together, our observations suggest that cancer-associated derepression of specific repetitive sequences can promote their RNA-driven genomic expansion, with potential implications on pericentromeric architecture.
Plasminogen-activator inhibitor type 1 and coronary artery disease.

The development of coronary artery disease, and specifically myocardial infarction, involves hyperplasia of arterial smooth muscle, the development of fatty streaks, atheroma formation, plaque rupture, and ultimately thrombus formation and vessel occlusion.1 These changes are in part genetically determined, as demonstrated by the fact that the risk of myocardial infarction in persons who have a first-degree relative with myocardial infarction is seven times the risk in persons who do not.2,3 This finding is often used to argue that coronary artery disease has a genetic basis, but the extent to which a shared environment contributes to the risk must also .
It All Fell Apart … Now How Do I Reconstruct My End-stage Flatfoot?

Plantigrade mechanical alignment is the hallmark of a successful extra-articular flatfoot reconstruction. When executed appropriately, joint-preserving flatfoot realignment surgery often results in good functional outcomes and acceptable patient satisfaction. However, flatfoot reconstruction can fail for multiple reasons including progressive arthritis at adjacent joints, soft-tissue hyperlaxity, nonunion of an osteotomy, and under or overcorrection of the deformity. The reasons for failure must be identified and adequately addressed to achieve a successful outcome following revision surgery. We frequently perform a triple arthrodesis, with an extended medial column fusion (as necessary), after recurrent medial column collapse. We present our diagnostic algorithm, surgical techniques, and pearls for the treatment of the failed extra-articular flatfoot reconstruction.
A phylogeographical analysis of the Bemisia tabaci species complex based on mitochondrial DNA markers

Mitochondrial 16S (~550 bp) and cytochrome oxidase I (COI) (~700 bp) sequences were utilized as markers to reconstruct a phylogeography for representative populations or biotypes of Bemisia tabaci. 16S sequences exhibited less divergence than COI sequences. Of the 429 characters examined for COI sequences, 185 sites were invariant, 244 were variable and 108 were informative. COI sequence identities yielded distances ranging from less than 1% to greater than 17%. Whitefly 16S sequences of 456 characters were analysed which consisted of 298 invariant sites, 158 variable sites and 53 informative sites. Phylogenetic analyses conducted by maximum parsimony, maximum‐likelihood and neighbour‐joining methods yielded almost identical phylogenetic reconstructions of trees that separated whiteflies based on geographical origin. The 16S and COI sequence data indicate that the B‐biotype originated in the Old World (Europe, Asia and Africa) and is most closely related to B‐like variants from Israel and Yemen, with the next closest relative being a biotype from Sudan. These data confirm the biochemical, genetic and behavioural polymorphisms described previously for B. tabaci. The consideration of all global variants of B. tabaci as a highly cryptic group of sibling species is argued.
Experimental demonstration of bandwidth reduction using Nyquist shaped PSK for flexible udWDM

Nyquist shaped PSK for flexible udWDM is proposed. 1.25Gb/s (2.5Gb/s) Nyquist-PSK with a 120° homodyne coherent receiver reduces the used optical bandwidth to 3.75GHz (5GHz) with receiver sensitivity of -48.5dBm at BER=10-3.
Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype

We have previously demonstrated that hepatitis C virus (HCV) core protein regulates cellular protooncogenes at the transcriptional level; this observation implicates core protein in the alteration of normal hepatocyte growth. In the present study, the transforming potential of the HCV core gene was investigated by using primary rat embryo fibroblast (REF) cells which were transfected with or without cooperative oncogenes. Integration of the HCV core gene resulted in expression of the viral protein in REF stable transformants. REF cells cotransfected with HCV core and H-ras genes became transformed and exhibited rapid proliferation, anchor-independent growth, and tumor formation in athymic nude mice. Results from these studies suggest that the core protein plays an important role in the regulation of HCV-infected cell growth and in the transformation to tumorigenic phenotype. These observations suggest a possible mechanism for this viral protein in the pathogenesis of hepatocellular carcinoma in HCV-infected humans.
Broad learning system: Feature extraction based on K-means clustering algorithm

Broad Learning System [1] proposed recently demonstrates efficient and effective learning capability. This model is also proved to be suitable for incremental learning algorithms by taking the advantages of random vector flat neural networks. In this paper, a modified BLS structure based on the K-means feature extraction is developed. Compared with the original broad learning system, acceptable performance on more complicated data set, such as CIFAR-10, is achieved. Furthermore, it is proved that the proposed model in [1] is flexible and potential in various applications.
Twenty-five-year trends in lifestyle and socioeconomic characteristics in Eastern Finland

Aims: Little is known about changes in lifestyle and socioeconomic characteristics among physical activity subgroups over time. This study aimed at assessing whether the lifestyle and the socioeconomic profile of people with either low total physical activity (TPA) or high TPA changed during 1972—97. Methods: Six independent cross-sectional surveys were carried out among a middle-aged population at five-year intervals in Eastern Finland, 1972—97. The participation rates varied from 71% to 95% (n=33,712). Physical activity during leisure time (LTPA) and occupational physical activity (OPA) were determined by a self-administered questionnaire. TPA was calculated by combining LTPA and OPA. Results: Men with low TPA were older, smoked more, and had a higher BMI than men with high TPA. The increase in BMI was almost fourfold in sedentary men (trend 0.4%/5 years, p=0.023 for trend) than in highly active men (trend 0.1%/5 years, p=0.044 for trend). Education no longer accounted for the socioeconomic difference after 1977. Sedentary women had a higher BMI and smoking prevalence than those with high TPA. The difference in age, education, and marital status disappeared between those two groups after 1977. Conclusions: The lifestyle and the socioeconomic profiles of people with both low TPA and high TPA have changed during 1972—97.
A Self-Oscillating System to Measure the Conductivity and the Permittivity of Liquids within a Single Triangular Signal

We present a methodology and a circuit to extract liquid resistance and capacitance simultaneously from the same output signal using interdigitated sensing electrodes. The principle consists in the generation of a current square wave and its application to the sensor to create a triangular output voltage which contains both the conductivity and permittivity parameters in a single periodic segment. This concept extends the Triangular Waveform Voltage (TWV) signal generation technique and is implemented by a system which consists in a closed-loop current-controlled oscillator and only requires DC power to, operate. The system interface is portable and only a small number of electrical components are used to generate the expected signal. Conductivities of saline NaCl and KCl solutions, being first calibrated by commercial equipment, are characterized by a system prototype. The results show excellent linearity and prove the repeatability of the measurements. Experiments on water-glycerol mixtures validate the proposed sensing approach to measure the permittivity and the conductivity simultaneously. We discussed and identified the sources of measurement errors as circuit parasitic capacitances, switching clock feedtrough, chage injection, bandwidth, charge injection, bandwidth, and control-current quality.
Heterochromatin polymorphism associated with 18S rDNA: a differential pathway among Hoplias malabaricus fish populations

The distribution of constitutive heterochromatin has showed a relevant association with karyotypic evolution in several animal groups. In the present paper, a polymorphic condition for a heterochromatic segment overlapping a nucleolar organizer region in the fish species Hoplias malabaricus from the Iguaçu river, Southern Brazil, was analyzed. In accordance with previous studies, this population belongs to cytotype A, showing 2n = 42 meta-submetacentric chromosomes, without differentiation of sex chromosomes. Three phenotypes were established with regard to the heterochromatin located near the centromere of chromosome pair 16, and named rr for homomorphic reduced bands, dd for homomorphic duplicated bands and rd for the heteromorphic condition. The rr phenotype was predominant (70.6%), followed by rd (23.5%) and dd (5.9%), showing Hardy-Weinberg equilibrium in the population. In addition, the 18S rDNA sites also show the polymorphic condition. A possible role for this NOR/heterochromatin segment in the evolution of sex chromosomes in other H. malabaricus cytotypes is discussed.
Effect of the Interface States on the Key Design Parameters in c-Si HIT Solar Cells

Study the impact of the different parameters by simulation is the most important step in the way to practically fabricate an effective structure of any solar cell device. Therefore, an investigation of the thin film of Heterojunction with Intrinsic Thin layer (HIT) solar cells was conducted in different interface trap density profile which is the most influential feature. The doping levels and the thicknesses of each layer of the structure were studied in these profiles. The results have showed the dependency of the open circuit voltage (Voc) measurement and the independency of the short circuit current (Jsc) on the interface quality (Dit) of the a-Si:H(i)/c-Si. Also, the HIT solar cells with different interface qualities have showed different attitudes or slope of changes in the variations of the key design parameters. Susceptibility to change rises as the quality of the interface of the HIT solar cell increases.
Acute Response of Some Iron Indices of Young Elite Wrestlers to Three Types of Aerobic , Anaerobic , and Wrestling Exercise

Th e present study was conducted to investigate the acute responses of some iron indices of young elite wrestlers to three types of aerobic, anaerobic, and wrestling exercises. A total of 24 elite volunteer wrestlers were randomly categorized into three groups (n=8) aerobic, anaerobic, and routine wrestling exercises. Th e exercises were conducted during three non-consecutive sessions within one week. Th e aerobic exercises included 35 min of continuous running with 130 beats per minute (BPM) on a treadmill; the anaerobic exercises included 15 min circuit movements and 15 min rest with 160 BPM, and the wrestling training included routine wrestling exercises. Blood sampling was done in the fi rst and third sessions in order to study the acute responses which included four stages of 1 h before, immediately, 3 h, and fi nally 24 h aft er exercises. Th e study of the acute response to the fi rst session showed that the type of exercise had no eff ect on serum iron (p=0.57). Furthermore, the serum ferritin (p=0.012) and TIBC (p=0.006) aff ected was aff ected by type of exercise. Th e study of the acute response to the second session showed that the type of exercise had no eff ect on serum ferritin (p=0.731) and TIBC (p=0.231), rather the serum iron was aff ected by the type of exercise (p=0.01). Conclusively, the study of acute response showed that wrestling exercises led to a decline in iron stores during exercise and reduced total iron binding capacity during a 24-h recovery period. Th e study of acute exercise aft er a short adaptation period showed that despite the fact that serum iron had no change in anaerobic and wrestling exercises over the passage of time, it changed during aerobic exercise and 24-h recovery periods. Furthermore, the progress of iron defi ciency was only observed in the fi rst stage which prevented its progress to the next stage.
UDP-sugar hydrolase isozymes in Salmonella enterica and Escherichia coli: silent alleles of ushA in related strains of group I Salmonella isolates, and of ushB in wild-type and K12 strains of E. coli, indicate recent and early silencing events, respectively.

Escherichia coli contains a single periplasmic UDP-glucose hydrolase (5'-nucleotidase) encoded by ushA. Salmonella enterica, serotype Typhimurium, also contains a single UDP-glucose hydrolase but, in contrast to E. coli, it is membrane-bound and is encoded by the non-homologous ushB gene; Salmonella enterica (Typhimurium) also contains a silent allele of the ushA gene (ushA0). In this report, we show that nearly all natural isolates of Salmonella contain both UDP-sugar hydrolases, i.e. they are UshA+ UshB+. The only exceptions are all from sub-group I (S. gallinarum, S. pullorum, and most Typhimurium strains), are UshA- UshB+, and several have been shown to contain an ushA0 allele. These data, together with the fact that these latter strains are closely related genetically, strongly suggests a recent silencing mutation(s). We also report the presence in E. coli K-12, and in natural isolates of E. coli, of a DNA sequence which is homologous to the ushB gene of Salmonella; since E. coli does not contain UshB activity, we tentatively refer to this sequence as ushB0. Since all E. coli strains investigated are UshB-, we conclude that the silencing mutation(s) occurred relatively early following the divergence of Escherichia coli and Salmonella from a common ancestor that was ushA+ ushB+.
Lock-ins and opportunities for sustainability transition

Purpose This study aims to provide an overview of sustainability in Flemish higher education (HE) by using the multi-level perspective (MLP) on sustainability transitions for a comprehensive empirical analysis of how sustainability is embedded in Flemish HE. Design/methodology/approach MLP was used as analytical framework to study the case and allow a focus on the interplay between innovative experiments in niche-practices, the characteristics of the prevailing regime (dominant structures, cultures and practices) and macro-trends at the landscape level. The data were collected through document analyses, surveys, in-depth interviews and a focus group. The empirical analysis was complemented with an extensive literature study. Findings In all, 9 landscape trends, 21 regime characteristics and 5 types of niches are identified. Furthermore, the multi-level analysis revealed 5 important lock-ins in the dominant regime that impede the upscaling of sustainable niches, 5 internal contradictions that destabilise the regime and can thus create windows of opportunity for niches to become viable alternatives and 16 opportunities for further embedding sustainability in HE. Originality/value The paper gives an original insight into the complexities of integrating sustainability in HE, highlights the important role of policy entrepreneurs to grasp emerging opportunities and offers them insight into how to create momentum and identify and fruitfully address windows of opportunity for a sustainability transition. It shows the potential and limits of the MLP for research on HE and outlines prospects for future research.