Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of the implementation of a 24-hour stroke thrombolysis emergency treatment for patients with acute ischemic stroke Running Title : 24 h stroke thrombolysis green channel for AIS

Aims and objectives: To assess the trends of intravenous (IV) thrombolysis with recombinant tissue plasminogen activator (rt-PA) among patients with acute ischemic stroke (AIS) admitted to our hospital between 2012 and 2014 and investigate the effects of a 24-hours (h) stroke thrombolysis emergency treatment on the intra-hospital clinical data and outcomes of these patients treated with IV rt-PA thrombolysis. Background: Although pre-notification of stroke by emergency medical services have been endorsed by the national recommendations and implemented in some developed countries, the development in China is limited. A cc ep te d A rt ic le This article is protected by copyright. All rights reserved. Design: A retrospective, single-center, observational study. Methods: Patients with AIS admitted to our hospital between January 2012 and December 2014 were included; those who received IV rt-PA thrombolysis within 4.5 h of onset were investigated. Demographic characteristics, including age and sex, and clinical data and outcomes, including onset-to-treatment time (OTT), door-to-needle time (DNT), premorbid Modified Rankin Scale score, and proportion of patients treated per year, were all recorded. Results: The proportion of patients with AIS who received thrombolytic therapy within 4.5 h increased from 2012 to 2014. The baseline characteristics of all patients were similar. Since the implementation of 24-h stroke thrombolysis emergency treatment in 2013, the median DNT significantly decreased in 2014 after implementation (42 min) compared with that in 2012 before implementation (81 min) (p < 0.05). Moreover, the admission-to-imaging time (37 vs. 33 vs. 36 min) and OTT (176 vs. 147 vs. 124 min) significantly decreased during the three years (p < 0.05). Conclusions: The 24-h stroke thrombolysis emergency treatment reduced in-hospital delay before thrombolytic therapy but had no effect on the functional outcomes of the patients with AIS. A cc ep te d A rt ic le This article is protected by copyright. All rights reserved. Relevance to clinical practice: This study provides opportunities to improve the experiences in using 24-h stroke thrombolysis emergency treatment in patients with AIS in clinical practice.
Interim results of a Phase Ib / IIa study of the entry inhibitor myrcludex B in chronic hepatitis D infected patients

Please cite this article as: Bogomolov, P., Alexandrov, A. , Voronkova, N. , Macievich, M. , Kokina, K. , Petrachenkova, M. , Lehr, T. , Lempp, F.A. , Wedemeyer, H. , Haag, M. , Schwab, M. , Haefeli, W.E. , Blank, A. , Urban, S. , Interim results of a Phase Ib/IIa study of the entry inhibitor myrcludex B in chronic hepatitis D infected patients, Journal of Hepatology (2016), doi: http://dx.doi. org/10.1016/j.jhep. 2016.04. 016
Clinical Practice Guidelines on the prevention , diagnosis and treatment of gallstones q European Association for the Study of the Liver ( EASL ) ⇑

Gallstones or cholelithiasis are a major public health problem in Europe and other developed countries and affect up to 20% of the population. Gallstone disease is the most common gastrointestinal disorder for which patients are admitted to hospitals in European countries [1]. The interdisciplinary care for patients with gallstone disease has advanced considerably during recent decades thanks to a growing insight into the pathophysiological mechanisms and remarkable technical developments in endoscopic and surgical procedures. In contrast, primary prevention for this common disease is still in its infancy. The EASL Clinical Practice Guidelines (CPG) on the prevention, diagnosis and therapy of gallstones aim to provide current recommendations on the following issues:
Effect of Carbon Fiber and Graphite Powder on Resistivity of Cement-based Sensor under Compression

Structural health monitoring currently becomes an important part in the maintenance of concrete structures. Thus, using of sensors to monitor the structural behavior is necessary. Cement-based sensors have been developed recently to be embeddable in structures and to be implemented by measuring the change in their resistivity. In this research, the electrical resistivity and compressive strength of the cement-based sensors with the addition of carbon fiber (2% and 4% by volume fraction) and graphite powder (2%, 4%, and 10% by weight of cement) were studied. Three water to binder ratios (w/b) that are 0.3, 0.4 and 0.5 were varied. For 28 days after demolding, the resistivity of the non-load-bearing sensors was monitored to determine the influence of their maturity. At the age of 28 days, their compressive strength was evaluated. Subsequently, the fractional change in resistivity (FCR) of the sensors was measured under a set of compressive loading, which comprised of three cycles of loading; first loading to the strain of 0.0025, then to 0.005 and 0.01. From the test results, it is showed that the carbon fiber was more favorable than the graphite powder. Although the addition of graphite powder could reduce the resistivity, it dropped the compressive strength and highly fluctuated the resistivity results of the cement-based sensors. In term of the piezoresistivity, all of the sensors when loaded provided good responses only when the compressive strain was less than 0.005.
rotocols old nanoflowers synthesized using Acanthopanacis cortex extract nhibit inflammatory mediators in LPS-induced RAW 264 . 7 acrophages via NF-B and AP-1 pathways

We reported the rapid synthesis (<8 s) of gold nanoparticles at room temperature using Acanthopanacis cortex extract (A-AuNPs). We characterized the A-AuNPs using several analytical techniques and found that nano-flower type A-AuNPs, which are known to possess a coarse surface with a high surface to volume ratio, conferring these particles with high binding capacity for various biological molecules. After confirming the stability of the nanoparticles, we investigated the anti-inflammatory effect of A-AuNPs in LPS-stimulated RAW264.7 cells. These nanoparticles inhibited LPS-induced iNOS and COX-2 protein as well as gene expression level, along with reduction of NO and PGE2 production. Furthermore, we observed old nanoflowers canthopanacis cortex reen synthesis nflammation that the A-AuNPs inhibited translocation of NFB and AP-1 through phosphorylation of MAPK signaling by western blot analysis. In summary, we synthesized gold nanoflowers in an economical and eco-friendly way using Acanthopanacis cortex extract and the resultant flower-like A-AuNPs had anti-inflammatory activity, highlighting their potential as therapeutic candidates for suppression of inflammatory-mediated diseases. © 2017 Elsevier B.V. All rights reserved.
Title Rapid-eye-movement-sleep ( REM ) associated enhancement ofworking memory performance after a daytime nap

Themain objective was to study the impact of a daytime sleep opportunity on workingmemory and the mechanism behind such impact. This study adopted an experimental design in a sleep research laboratory. Eighty healthy college students (Age:17-23, 36 males) were randomized to either have a polysomnography-monitored daytime sleep opportunity (Napgroup, n=40) or stay awake (Wake-group, n=40) between the two assessment sessions. All participants completed a sleep diary and wore an actigraph-watch for 5 days before and one day after the assessment sessions. They completed the state-measurement of sleepiness and affect, in addition to a psychomotor vigilance test and a working memory task before and after the nap/wake sessions. The two groups did not differ in their sleep characteristics prior to and after the lab visit. The Nap-group had higher accuracy on the working memory task, fewer lapses on the psychomotor vigilance test and lower state-sleepiness than theWakegroup. Within the Nap-group, working memory accuracy was positively correlated with duration of rapid eye movement sleep (REM) and total sleep time during the nap. Our findings suggested that “sleep gain” during a daytime sleep opportunity had significant positive impact on working memory performance, without affecting subsequent nighttime sleep in young adult, and such impact was associated with the duration of REM.While REM abnormality has long been noted in pathological conditions (e.g. depression), which are also presented with cognitive dysfunctions (e.g. working memory deficits), this was the first evidence showing working memory enhancement associated with REM in daytime napping in college students, who likely had habitual short sleep duration but were otherwise generally healthy.
Full-wave segmentation analysis of arbitrarily shaped planar circuit

This paper presents a novel full-wave segmentation method for analyzing a complex and large microwave planar circuit which is divided into several smaller segments with corresponding multiport network parameters. They are obtained by a full-wave space-domain integral-equation technique in connection to a proposed excitation model based on the equivalence principle. The integral equation is solved numerically by Galerkin's procedure resulting in the generalized scattering-matrix (GSM) descriptions of all the subcircuit segments. The combination of these GSM's yields an overall network characterization of the composite circuit. Rigorous convergence studies and extensive validity checks confirm the reliability and accuracy of the proposed method. The novel technique immediately demonstrates its obvious application for quantitative characterization of higher order modes associated with a microwave-circuit discontinuity problem. Finally, very good agreement is obtained in a comparative study of an arbitrary planar structure analyzed by our full-wave method with and without segmentation, respectively.
Analysis And Evaluation Of A Project Of Technological Innovation For The Transport of Petrochemical Bulk Resins via Model Rail

The changes that are occurring in all areas, forcing organizations to fit the constant search for new ways to plan and conduct business. An organization must be prepared to pursue new ideas, products, markets, and ways of accomplishing tasks, creating an environment that encourages new developments and allows ideas and concepts that might turn into future business. As for distribution of petrochemical resins in bulk form in Brazil, we see the need to check the possibility of new alternatives for optimizing the processes, and therefore the competitiveness of companies. Thus, this study aims to verify the feasibility of using aluminum containers in the distribution of petrochemical resins in bulk form in Brazil. Issues on competitiveness logistics, project analysis and the theory of real cases have been discussed in order to provide the study with theoretical basis. The study was carried out in two steps: the first one a market research was performed through interviews with those responsible for logistics companies that took part in the research, and the second step consisted of the calculation of economic and financial indicators for the implementation of the project to build containers for an aluminum company located in Caxias do Sul. Thus, we can conclude that through market research and the calculation of the economic and financial viability for the Alfa. It is feasible to implement the project of manufacturing of aluminum container.
Protein identification and profiling with mass spectrometry

As a consequence of the completion of multiple genome projects, there has emerged a need for the efficient evaluation of complex samples of proteins on a broad scale [1–4]. Mass spectrometry (MS) has rapidly become one of the most important tools for the identification of proteins (Fig. 1) largely due to the introduction of new biomolecule-compatible ionization techniques such as electrospray ionization (ESI) [5] and matrix-assisted laser desorption/ionization (MALDI) [6] as well as high resolution mass analyzers. Using these technologies, proteolytic peptides can be ionized intact into the gas phase and their masses accurately measured. Based on this information, proteins can readily be identified using a methodology called protein mass mapping or peptide mass mapping, in which these measured masses are compared to predicted values derived from a protein database. Further sequence information can also be obtained by fragmenting individual peptides in tandem MS experiments. In addition, large scale changes in protein expression levels between two different samples can be assessed using quantitative tools such as two-dimensional gel electrophoresis (2D-GE) or staple isotope labeling in conjunction with mass spectrometry measurement.
Revisiting stock market development and economic growth nexus: The moderating role of foreign capital inflows and exchange rates

Abstract This study re-examines the stock market development and economic growth nexus. Also, examine the moderating role of foreign capital inflows and exchange rate on the relationship between stock market development and economic growth of Malaysia during 1981–2016. This study applies Granger test, ARDL (with bound testing) approach, and multivariate regression approach to examine extent and direction of the relationships among variabels, empirically. Granger causality test suggests that there are unidirectional effects of stock market development to Malaysian economic growth. Using the bound test for co-integration, this study finds there is a long run association between stock market development and economic growth. However, ARDL model reports that, in the short run and long run, stock market promotes the economic growth of Malaysia which is consistent with Granger causality test. Aditionally, foreign capital inflows and exchange rate has significant positive and negative moderating effects, respectively, on the relationship between stock market development and economic growth. Nevertheless, when both foreign capital inflows and exchange rate interact with each other, there is a joint positive effect on the relationship between stock market development and economic growth. Therefore, Malaysian policy-makers should consider both foreign capital inflows and exchange rate in formulating the economic policy. Moreover, special attention should be given on the external debt, which constitutes a significant proportion of foreign capital inflows, because of its negative impact on economic growth. At the same time, foreign direct investments with flexible exchange rate should be encouraged to foster both stock market and economic growth.
Vessel Strikes to Large Whales Before and After the 2008 Ship Strike Rule

To determine effectiveness of Seasonal Management Areas (SMAs), introduced in 2008 on the U.S. East Coast to reduce lethal vessel strikes to North Atlantic right whales, we analyzed observed large whale mortality events from 1990–2012 in the geographic region of the “Ship Strike Rule” to identify changes in frequency, spatial distribution, and spatiotemporal interaction since implementation. Though not directly coincident with SMA implementation, right whale vessel‐strike mortalities significantly declined from 2.0 (2000–2006) to 0.33 per year (2007–2012). Large whale vessel‐strike mortalities have decreased inside active SMAs, and increased outside inactive SMAs. We detected no significant spatiotemporal interaction in the 4‐year pre‐ or post‐Rule periods, although a longer time series is needed to detect these changes. As designed, SMAs encompass only 36% of historical right whale vessel‐strike mortalities, and 32% are outside managed space but within managed timeframes. We suggest increasing spatial coverage to improve the Rule's effectiveness.
Energy Optimization using Cloud Offloading Algorithm

—Computational offloading is an effective method to address the limited battery power of a mobile device, by executing some components of a mobile application in the cloud. In this paper, a novel offloading algorithm called ‘Dynamic Programming with Hamming Distance Termination’ (denoted DPH) is presented. The algorithm uses randomization and a hamming distance termination criterion to find a nearly optimal offloading solution quickly. The algorithm will offload as many tasks as possible to the cloud when the network transmission bandwidth is high, thereby improving the total execution time of all tasks and minimizing the energy use of the mobile device. Furthermore, the algorithm is extensible to handle larger offloading problems without a loss of computational efficiency.
IMPACT OF FEED ON GROWTH AND DEVELOPMENT OF DIFFERENT BROILER-STRAINS

An experiment was carried out on three broiler-strains viz- Vencove (B 1 ), Hubbard (B 2 ) and Croiler (B 3 ) at the selected poultry farms in Gorakhpur region with the objective to investigate a suitable feed/ration for local poultry raisers. For this purpose three type of feeds were taken as broiler mash 100 percent (F1) considered as a control group, soybean 30 percent + maize 70 percent (F 2 ) and broiler mash 30 percent + maize 70 percent (F 3 ) supplied to 28000, 35150 and 27250 number of birds in each experimental group, respectively with three replications. Initial average body weight of day old, average feed intake, feed conversion efficiency, body weight gain and mortality of Table birds, was recorded and analyzed. The average feed intake in treatment groups F 1 , F 2 and F3 was estimated 2.26kg, 2.16kg and 2.23kg, respectively, body weight gain in these groups were calculated as 1.07kg, 1.15kg and 1.08kg per bird and the corresponding value for feed conversion efficiency was 1.94kg, 1.76kg and 1.89kg per bird in all the groups, respectively. Results of experiment show F2 feed was the best feed in overall experiment. Feed intake, body weight gain and feed conversion efficiency for all the three treatment groups were found to be highly significant (P<0.01).
Preparation and Microwave Absorption Properties of Polyaniline and Magnetite Core-Shell-Structured Hybrid

In this study, polyaniline and Fe3O4 (PAN@Fe3O4) hybrids are fabricated and their microwave absorption property is studied. PAN@Fe3O4 hybrids are fabricated by the in situ aniline polymerization at spherical of Fe3O4 which is prepared by the solvothermal process. Fourier-transform infrared spectrophotometer (FTIR), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) are applied to confirm the composition of the fabricated PAN@Fe3O4 hybrids. The morphologies of PAN@Fe3O4 hybrids are studied by scanning electron microscope (SEM) and transmission electron microscopy (TEM). The content of polyaniline in the PAN@Fe3O4 hybrids is calculated by thermogravimetric analysis (TGA). The magnetic properties of PAN@Fe3O4 hybrids are characterized by vibrating sample magnetometer (VSM). The microwave absorption property of PAN@Fe3O4 hybrids are measured on a vector network analyzer. The research show that the microwave absorptions property of the obtained PAN@Fe3O4 hybrids can be adjusted by controlling the in situ aniline polymerization at spherical of Fe3O4.
A NOTE ON PSEUDOVARIETIES OF COMPLETELY REGULAR SEMIGROUPS

A paper of Almeida and Trotter [‘The pseudoidentity problem and reducibility for completely regular semigroups’, Bull. Aust. Math. Soc.63 (2001), 407–433] makes essential use of free profinite semigroupoids over profinite graphs with infinitely many vertices. It has since been shown that such structures must be handled with great care. In this note, it is verified that the required properties hold for the profinite graphs considered by Almeida and Trotter, thereby filling the gaps in the proof.
International Journal of Systematic and Evolutionary Microbiology Pseudomonas matsuisoli sp . nov . , isolated from a soil sample in Matsu Island ( Taiwan )

Abstract: An aerobic, Gram-stain negative, rod-shaped and polar-flagellum bacterium (designated as strain CC-MHH0089T) was isolated from a soil sample in Matsu Island (Taiwan). Strain CC-MHH0089T grows at temperature 15-30oС, pH 5.0-10.0 and tolerate ≦8% (w/v) NaCl. The 16S rRNA gene sequence analysis showed pairwise sequence similarity to Pseudomonas azotifigens JCM 12708T (97.3%), Pseudomonas balearica BCRC 17184T (96.7%) and lower sequence similarity to others (<96.0%). According to the DNA-DNA association, the relatedness values of strain CCMHH0089T with P. azotifigens JCM 12708T was 38.3% (reciprocal values was 19.5%). The evolutionary trees constructed based on 16S rRNA, gyrB and rpoB gene sequences revealed varying phylogenetic neighborhood of strain CC-MHH0089T with regard to most closely related type strains. The predominant quinone system is ubiquinone (Q-9) and the DNA G+C content is 63.6 mol%. The major fatty acids were C12:0, C16:0, C17:0, C19:0 cyclo ω8c and summed features 2, 3 and 8 consisting of C14:0 3-OH / C16:1 iso I, C16:1 ω7c/C16:1 ω6c and C18:1 ω7c/C18:1 ω6c, respectively. The major polar lipids were phosphatidylcholine, phosphatidylglycerol, phosphatidylethanolamine and diphosphatidylglycerol. According to distinct phylogenetic, phenotypic and chemotaxonomic features, strain CC-MHH0089T is proposed to represent a novel species within the genus Pseudomonas for which the name Pseudomonas matsuisoli sp. nov. is proposed. The type strain is CC-MHH0089T (=BCRC 80771T =JCM 30078T).
Factor XIII Co-Treatment with Hemostatic Agents in Hemophilia A Increases Fibrin α-Chain Crosslinking Running Title: FXIII Co-Treatment with Hemostatic Agents in Hemophilia A

Background: Hemophilia A results from the absence, deficiency, or inhibition of factor VIII (FVIII). Bleeding is treated with hemostatic agents (FVIII, recombinant activated factor VIIa [rFVIIa], antiinhibitor coagulation complex [FEIBA], or recombinant porcine FVIII [rpFVIII]). Despite treatment, some patients have prolonged bleeding. Factor XIII-A2B2 (FXIII) is a protransglutaminase. During clot contraction, thrombin-activated FXIII (FXIIIa) crosslinks fibrin and α2-antiplasmin, which promotes red blood cell retention and increases clot stability and weight. We hypothesized that FXIII co-treatment in hemophilia would accelerate FXIII activation, leading to increased fibrin crosslinking. Methods: FVIII-deficient plasma and whole blood were clotted with or without hemostatic agents (FVIII, rFVIIa, FEIBA or rpFVIII) and/or FXIII. Effects on FXIII activation, thrombin generation, fibrin and α2-antiplasmin crosslinking, clot formation, and clot weight were measured by western blotting, calibrated automated thrombography, thromboelastography, and clot contraction assays. Results: Compared to FVIII-treated hemophilic plasma, FVIII+FXIII co-treatment accelerated FXIIIa formation without increasing thrombin generation. Compared to bufferor FXIII-treated hemophilic plasma, FVIII treatment and FVIII+FXIII co-treatment increased the generation and amount of crosslinked fibrin, including α-chain-rich high molecular weight species and crosslinked α2antiplasmin. In the presence of FVIII inhibitors, compared to hemostatic treatments (rFVIIa, FEIBA or rpFVIII) alone, FXIII co-treatment increased whole blood clot weight.