Miracle-dz/UniFAR-FTUs huggingface dataset:
Possible Function of Caudal Nuclear Pocket

Many temporarily functioning proteins are generated during the replacement of nucleoproteins in the nuclei of late spermatids and seem to be degraded in the nucleus. This study was designed to clarify the involvement of the ubiquitin-proteasome degradation system in the nucleus of rat developing spermatids. Thus, we studied the nuclear distribution of polyubiquitinated proteins (pUP) and proteasome in spermiogenic cells and sperm using postembedding immunoelectron microscopy. We divided the nuclear area of late spermatids into two regions: (1) a dense area composed of condensed chromatin and (2) a nuclear pocket in the neck region. The latter was located in the caudal nuclear region and was surrounded by redundant nuclear envelope. We demonstrated the presence of pUP in the dense area and nuclear pocket, proteasome in the nuclear pocket, and clear spots in the dense area of rat spermatids. Using quantitative analysis of immunogold labeling, we found that fluctuation of pUP and proteasome levels in late spermatogenesis was mostly synchronized with disappearance of histones and transitional proteins reported previously. In the nuclei of human sperm, pUP was detected in the dense area, whereas proteasome was in the nuclear vacuoles and clear spots. These results strongly suggest that pUP occur in the dense nuclear area of developing spermatids and that the ubiquitin-proteasome system is more actively operational in the nuclear pocket than dense area. Thus, the nuclear pocket might be the degradation site for temporarily functioning proteins generating during condensation of chromatin in late spermatids.
Alcohol Consumption Measures

Contributions from markedly different kinds of studies—biogenetic, epidemiologic, longitudinal, population surveys, clinical analog, and treatment outcome—have advanced our understanding of alcohol use and abuse. Although different studies examine issues from different perspectives, they have one thing in common—the assessment of alcohol consumption. Alcohol consumption, however, is a complex behavior that can change considerably over time. Twenty-five years ago very few drinking measures existed. Today the situation has changed dramatically (Alanko 1984; Room 1990; L.C. Sobell and Sobell 1992, 1995). Multiple measures are now available. Thus, the issue now is how to select the best measure for a given purpose, as each measure has advantages and limitations. This chapter, like most in this Guide, was first published in 1995 (L.C. Sobell and Sobell 1995). This update reviews the literature on drinking measures published through mid-2001, presents new measures that met the inclusion criteria for this volume, and provides recommendations about what drinking measures to use and for what purpose. When selecting a drinking measure, a decision must be made about the type of information needed (e.g., level of precision, timeframe, amount of time that can be devoted to data collec­ tion). Ultimately, the utility of a drinking measure for research and/or clinical purposes will rest on its intended use. Therefore, the following ques­ tions need to be answered when selecting a drink­ ing measure: • How is the information to be used? • Over what time interval should data be collected? • How long will it take to collect the data? • What type of drinking information (e.g., precision) is needed? • What level of training or expertise is needed to administer the instrument? • Is the measure psychometrically reliable and valid?
Low-noise amplifier with 12.1 dB gain and 5.456 dB NF for V-band applications in GaAs 0.15μm pHEMT process

In this paper, a two-stage low-noise amplifier (LNA) designed for V-band applications is presented. Both stages are the common source-common gate (CS-CG) cascoded topologies with inductive degeneration structure for minimizing the noise figure (NF). This proposed LNA is implemented in a GaAs 0. 15μm pHEMT process technology, which achieves a peak gain of 12.1 dB, a NF of 5.456 dB, and an input P1dB of -20 dBm at the 56.8 GHz frequency. The 3dB bandwidth is from 54.9 GHz to 58 GHz. The power consumption of the proposed LNA is 26.6 mW from the 1.8V voltage supply.
Identification and characterization of YME1L1, a novel paraplegin-related gene.

A gene responsible for an autosomal recessive form of hereditary spastic paraplegia (SPG7) was recently identified. This gene encodes paraplegin, a mitochondrial protein highly homologous to the yeast mitochondrial AAA proteases Afg3p, Rca1p, and Yme1p, which have both proteolytic and chaperone-like activities at the inner mitochondrial membrane. By screening the expressed sequence tag database, we identified and characterized a novel human gene, YME1L1 (YME1L1-like1, HGMW-approved symbol). This gene encodes a predicted protein of 716 amino acids highly similar to all mitochondrial AAA proteases and in particular to yeast Yme1p. Expression and immunofluorescence studies revealed that YME1L1 and paraplegin share a similar expression pattern and the same subcellular localization in the mitochondrial compartment. YME1L1 may represent a candidate gene for other forms of hereditary spastic paraplegia and possibly for other neurodegenerative disorders.
A Virtual Reality System for Training Operators

This paper presents an immersive system for virtual reality-based training of operators. Recent studies show that virtual reality simulations may be helpful in different fields, namely, industry and education. In this particular case we present a simulator for the training of tower cranes operators reducing their costs and risks. This immersive system integrates real-time 3D computer graphics with other modalities, such as, user pose tracking, stereoscopic head-mounted display, pendant remote controller, physics behaviour, and spatial sound, in order to create a more realistic and immersive experience to the user. The results demonstrate two different simulator setups, one fixed and one portable, where the fixed offer a larger traceable area and the portable can be moved wherever is needed. The simulator is robust, reliable and provides an experience very similar to reality. Furthermore, it is possible to extend the simulation to other types of cranes and different types of scenarios.
Identification of the major allergens of Charybdis feriatus (red crab) and its cross-reactivity with Portunus pelagicus (blue crab).

BACKGROUND Tropomyosin and arginine kinase have been identified as the major allergens in multiple species of crab. Charybdis feriatus is an important commercial crab in this country. OBJECTIVE To characterize the major allergens of C. feriatus using a proteomics approach and subsequently to identify the allergens involved in cross-reactivity with Portunus pelagicus. METHODS Raw and boiled extracts of the crabs were prepared from crab meat. The protein profile of the extracts was determined by SDS-PAGE and two-dimensional electrophoresis (2-DE). Major allergens were identified by the immunoblotting test using sera from 50 patients with crab allergy. The major allergens were further identified by 2-DE immunoblotting. The major allergenic spots were then excised, digested by trypsin and identified by mass spectrometry analysis. The immunoblotting inhibition test was performed to study the crossreactivity between red crab and blue crab allergens using sera from 20 patients with allergy to both red and blue crabs. RESULTS At least 20 protein bands between 13 to 250 kDa were detected in the SDS-PAGE gel of raw extract, while boiled extract procuced fewer protein bands. Proteins of 36 kDa and 41 kDa were recognized as the major allergens of the crab. The major allergenic spot sequences of the 36 and 41 kDa proteins were identified as crab tropomyosin and arginine kinase, respectively. All IgE-binding proteins, including both major allergens, were found to be cross-creative with P. pelagicus allergens. CONCLUSIONS In addition to tropomyosin, arginine kinase was also identified as the major allergen of C. feriatus among our local crab-allergic patients. Cross-reactivity of this crab with P. pelagicus was demonstrated in this study.
Rapid dental development in a Middle Paleolithic Belgian Neanderthal

The evolution of life history (pace of growth and reproduction) was crucial to ancient hominin adaptations. The study of dental development facilitates assessment of growth and development in fossil hominins with greater precision than other skeletal analyses. During tooth formation, biological rhythms manifest in enamel and dentine, creating a permanent record of growth rate and duration. Quantification of these internal and external incremental features yields developmental benchmarks, including ages at crown completion, tooth eruption, and root completion. Molar eruption is correlated with other aspects of life history. Recent evidence for developmental differences between modern humans and Neanderthals remains ambiguous. By measuring tooth formation in the entire dentition of a juvenile Neanderthal from Scladina, Belgium, we show that most teeth formed over a shorter time than in modern humans and that dental initiation and eruption were relatively advanced. By registering manifestations of stress across the dentition, we are able to present a precise chronology of Neanderthal dental development that differs from modern humans. At 8 years of age at death, this juvenile displays a degree of development comparable with modern human children who are several years older. We suggest that age at death in juvenile Neanderthals should not be assessed by comparison with modern human standards, particularly those derived from populations of European origin. Moreover, evidence from the Scladina juvenile and other similarly aged hominins suggests that a prolonged childhood and slow life history are unique to Homo sapiens.
Factores asociados a respuesta de abatacept subcutaneo en artritis reumatoide

INTRODUCCION Dado que la artritis reumatoide es la artropatia inflamatoria mas frecuente en el mundo, siendo altamente discapacitante y causando gran impacto de alto costo, se busca ofrecer al paciente opciones terapeuticas y calidad de vida a traves del establecimiento de un tratamiento oportuno y eficaz, teniendo presentes aquellos predictores de respuesta previo a instaurar determinada terapia. Existen pocos estudios que permitan establecer aquellos factores de adecuada respuesta para inicio de terapia biologica con abatacept, por lo cual en este estudio se busca determinar cuales son esos posibles factores. METODOLOGIA Estudio analitico de tipo corte transversal de 94 pacientes con diagnostico de AR, evaluados para determinar las posibles variables que influyen en la respuesta a terapia biologica con abatacept. Se incluyeron 67 de los 94 pacientes al modelo de regresion logistica, que son aquellos pacientes en que fue posible medir la respuesta al tratamiento (respuesta EULAR) a traves de la determinacion del DAS 28 y asi discriminar en dos grupos de comparacion (respuesta y no respuesta). DISCUSION DE RESULTADOS La presencia de alta actividad de la enfermedad al inicio de la terapia biologica, aumenta la probabilidad de respuesta al tratamiento respecto al grupo con baja/moderada actividad de la enfermedad; OR 4,19 - IC 95%(1,18 – 14.9), (p 0,027). La ausencia de erosiones oseas aumenta la probabilidad de presentar adecuada respuesta a la terapia biologica respecto aquellos con erosiones, con un OR 3,1 (1,01-9,55), (p 0,048). Niveles de VSG y presencia de manifestaciones extra-articulares son otros datos de interes encontrados en el analisis bivariado. Respecto a las variables o caracteristicas como predictores de respuesta al tratamiento con abatacept, se encuentran estudios que corroboran los hallazgos de este estudio, respecto al alto puntaje del DAS 28 al inicio de la terapia (9, 12). CONCLUSIONES Existen distintas variables que determinan la respuesta a los diferentes biologicos para manejo de AR. Es imprescindible evaluar dichos factores de manera individual con el fin de lograr de manera efectiva el control de la enfermedad y asi mejorar la calidad de vida del individuo (medicina personalizada). Existen variables tales como la alta actividad de la enfermedad y la ausencia de erosiones como predictores de respuesta en la terapia con abatacept.
Precise self-localization of a walking robot on rough terrain using parallel tracking and mapping

Purpose – The purpose of this paper is to describe a novel application of the recently introduced concept from computer vision to self‐localization of a walking robot in unstructured environments. The technique described in this paper enables a walking robot with a monocular vision system (single camera) to obtain precise estimates of its pose with regard to the six degrees of freedom. This capability is essential in search and rescue missions in collapsed buildings, polluted industrial plants, etc.Design/methodology/approach – The Parallel Tracking and Mapping (PTAM) algorithm and the Inertial Measurement Unit (IMU) are used to determine the 6‐d.o. f. pose of a walking robot. Bundle‐adjustment‐based tracking and structure reconstruction are applied to obtain precise camera poses from the monocular vision data. The inclination of the robot's platform is determined by using IMU. The self‐localization system is used together with the RRT‐based motion planner, which allows to walk autonomously on rough, previ.
Dopamine D 1-like receptors regulate the 1 A-adrenergic receptor in human renal proximal tubule cells and D 1-like dopamine receptor knockout mice

Riley Charles Ennis, Laureano D. Asico, Ines Armando, Jian Yang, Jun B. Feranil, Julie A. Jurgens, Crisanto S. Escano, Jr., Peiying Yu, Xiaoyan Wang, David R. Sibley, Pedro A. Jose, and Van Anthony M. Villar Thomas Jefferson High School for Science and Technology, Alexandria, Virgina; Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland; Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland
Extraction d’expressions-cibles de l’opinion : de l’anglais au français (Opinion Target Expression extraction : from English to French)[In French]

Dans cet article, nous présentons le développement d’un système d’extraction d’expressions-cibles pour l’anglais et sa transposition au français. En complément, nous avons réalisé une étude de l’efficacité des traits en anglais et en français qui tend à montrer qu’il est possible de réaliser un système d’extraction d’expressions-cibles indépendant du domaine. Pour finir, nous proposons une analyse comparative des erreurs commises par nos systèmes en anglais et français et envisageons différentes solutions à ces problèmes.
Discretization of 3D Models Using Voxel Elements of Different Shapes

This paper presents a voxelization algorithm that uses elements of various shapes that are not larger than a single voxel. Elements are chosen from a palette in order to minimize the deviation from the actual object according to a given metric. An analytical framework is presented and then an implementation based on a statistical sampling on the object is proposed. The result obtained is used to guide the recreation of the original model using small components that resemble the palette elements but emphasize the artistic nature of the reconstruction. Several examples where the proposed technique has been used to create some models with artistic and advertising purposes are presented to show the effectiveness of the technique.
Topical corticosteroids in plaque psoriasis: a systematic review of efficacy and treatment modalities

Introduction Topical steroids are used for more than 50 years to treat mild‐to‐moderate plaque psoriasis. The purpose of this systematic review was to evaluate the efficacy but also the optimal modalities of administration of topical corticosteroids in psoriasis i.e. influence of steroid potency on clinical response, putative impact of topical formulation, occlusion procedure, rate of application to control the initial response and the potential interest of a maintenance treatment to prolong psoriasis clearance.
Quantitative studies of mycobacterial populations in sputum and saliva.

In the past, quantitative bacteriology was of some value in the clinical management of tuberculosis (1, 2), but interest in this subject has waned markedly in the era of effective chemotherapy. The present increasing importance of quantitative bacteriology in other infectious diseases, such as pyelonephritis (3), and in non tuberculous respiratory disease (4), and the availability of an effective method for enumeration of culturable tubercle bacilli (5) prompted this study in patients with pulmonary mycobacterial infections. Serial enumeration of culturable tubercle bacilli in sputum and saliva was initiated prior to chemotherapy and performed during chemotherapy through sputum "conversion. " 4
BONE MARROW ORIGIN OF DECIDUAL CELL PRECURSORS

Decidual cells constitute a distinctive cell class that appear in the endometrium of mammal ian uteri during pregnancy, usually after the implantation of the blastocyst. These ceils, along with other cells of the endometrial stroma, form a distinct layer referred to as decidual tissue. The decidual cell reaction can also be artificially induced in the hormonally primed pseudopregnant uterine endometrium by mechanical or chemical stimuli (1, 2). Several biological functions have been attributed to decidual ceils: (a) a nutritive role for the embryo postulated on the basis of their high glycogen content (3), (b) secretion of prolactin (4-6) and prostaglandins (7), and (c) maintenance of pregnancy by protecting maternal tissue from destructive invasion by trophoblast cells of the placenta (8) or by protecting the allogeneic fetoplacental unit from an immunological rejection by the mother (9, 10). For example, ectoplacental cones transplanted in the uterus ofovariectomized mice resulted in trophoblast cell invasion into the myometrial layer, which would otherwise be prevented in decidualized mice (8). Furthermore, pr imary allogeneic skin grafts transplanted into the decidualized uteri of pseudopregnant rats or rats in the preimplantation stage of pregnancy were found to survive significantly longer (usually to the time equivalent to term pregnancy) than those inserted into nondecidualized uteri (10). Tha t orthotopically transplanted skin allografts in these rats did not survive longer appears to exclude the possibility of immunosuppression mediated by systemic hormones. Finally, materials released from decidual tissue in culture have been reported to demonstrate a suppressive function in the mixed lymphocyte reaction (11), and, similarly, extracts of decidual tissue have been associated with suppression of the antibody response of normal adult spleen cultures (12). The cell type of the decidua responsible for the suppression was not identified in either case. Among a number of studies reported in the literature to examine the immediate origin of decidual cells, those using [aH]thymidine as a marker of cell proliferation (13-16) indicate that decidual cells arise from a proliferation and differentiation of endometrial stromal cells under the influence of ovarian hormones. However, the ultimate origin of the decidual cell precursors remains unknown. No information is available as to whether such precursors are local residents of the endometrium or migrants from elsewhere. In view of the possibility that decidual cells may play an immunological role in the maintenance of pregnancy, and in accordance with the knowledge that all ceils of the adult immune system are derivatives of the bone
Dual Sales Channel Management with Service Competition

We study a manufacturer’s problem of managing his direct online sales channel together with an independently owned bricks-and-mortar retail channel, when the channels compete in service. We incorporate a detailed consumer channel choice model in which the demand faced in each channel depends on the service levels of both channels as well as the consumers’ valuation of the product and shopping experience. The direct channel’s service is measured by the delivery lead time for the product; the retail channel’s service is measured by product availability. We identify optimal dual channel strategies that depend on the channel environment described by factors such as the cost of managing a direct channel, retailer inconvenience, and some product characteristics. We also determine when the manufacturer should establish a direct channel or a retail channel if he is already selling through one of these channels. Finally, we conduct a sequence of controlled experiments with human subjects to investigate whether our model makes reasonable predictions of human behavior. We determine that the model accurately predicts the direction of changes in the subjects’ decisions, as well as their channel strategies in response to the changes in the channel environment. These observations suggest that the model can be used in designing channel strategies for an actual dual channel environment. 1
Acceptability and Satisfaction Associated With the Introduction of the PrePex Circumcision Device in Maputo, Mozambique

Background:Adult device circumcision may potentially reach more men in Sub-Saharan Africa, with fewer human resource and capacity needs than surgical procedures. Despite these advantages, little is known about device acceptability, including pain and maintaining the device in situ. Methods:Healthy, HIV-negative men, between 18 and 49 years, in a Maputo clinic, were consecutively asked to participate in a circumcision device study that included assessing acceptability. Clinical forms and self-administered surveys were used to collect data at various times during the circumcision process for consenting men. Data were entered into a central database and analyzed using statistical software. Results:Between May and July, 2013, 504 men received device circumcision. Placement was painless for 98.2% of the male population, but the pain was more common during removal with 38.3% reporting severe or unbearable and 21.5% moderate pain. Satisfaction was high at both time points with 88.8% and 92.6% of men being very or somewhat satisfied at placement and removal, respectively. Half of the male population (50.2%) was very or somewhat comfortable with the device in situ; whereas, 36.8% were somewhat or very uncomfortable. Common device difficulties experienced were painful erections (38.5%) and difficult urination (21.8%) and hygiene (21.4%). By the final clinic visit at day 49, 90.4% of them were very or somewhat satisfied with the procedure. Discussion:High levels of satisfaction were reported for device circumcision, despite the pain noted during removal and some challenges with the device in situ. Given the advantages and acceptability among Mozambican men in this study, device circumcision could be offered, when clinically appropriate, as an alternative to surgery.
A Histological Comparison of Contracted and Non‐Contracted Capsules Around Silicone Breast Implants

A single blind comparison of capsular tissue obtained from both breasts from 7 patients in whom unilateral contracture had occurred leads to the following conclusions: (1) The presence of droplets (presumed to be silicone, or extractable silicone as identified by IR) in capsular tissue does not correlate with the clinical finding of firmness. (2) Contracted capsules are apt to be significantly more cellular, largely as a result of an increased fibroblast population. (3) The apparent severity of inflammation in a biopsy of a capsule does not correlate with the clinical degree of firmness in the breast. (4) In the 7 cases studied, capsule thickness or vascularity, collagen alignment, staining uptake, presence of foreign bodies, or presence of an inner cell layer of macrophages did not correlate with the clinical finding of firmness.