Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychosis symptoms following aberrant immunity in the brain

Neuroinflammation in the brain is thought related to the emergence of various psychoses, although the identifying regional significance, the involvement of immune-cells and lymphocytic activity, and ways for the therapeutic recovery are under the effort of researchers. We recently revealed that the cerebellar acute inflammation causes the symptoms manifested in mood disorders or developmental disorders, which were associated with hyperexcitability due to immune-triggered plasticity and the overconnectivity between the inflamed cerebellum and prefrontal cortex (Yamamoto et al., 2019). Here, we give a perspective regarding the emergence of psychoses focusing on the aberrant immunity, the relevance of dysfunctions in brain regions including the cerebellum, and potential therapeutic ways via metabolism.
Effects of anti-auxins on secondary aerenchyma formation in flooded soybean hypocotyls

Abstract In flooded hypocotyl of soybean (Glycine max), cell division in phellogen and the elongation of these cells are enhanced, and thereby a secondary aerenchyma with high porosity is produced. Auxin controls cell division and cell elongation in many plants, so we studied its role in secondary aerenchyma development. Soybean plants with fully expanded unifoliolate leaves were flooded for 6 d with solutions (100 μM each) of seven anti-auxins. TIBA, NPA, HFCA, 1-NOA, or CHPAA did not restrict the secondary aerenchyma formation, while MH moderately suppressed the aerenchyma development, and PCIB strongly inhibited the development of phellogen and secondary aerenchyma. However, the endogenous IAA concentrations in the flooded hypocotyls did not increase or decrease relative to the controls until 72 h, when a secondary aerenchyma was observed. From these results, it is unclear whether auxin plays an important role in the process of secondary aerenchyma formation under flooding.
A cost-benefit analysis of afforestation as a 1 climate change adaptation measure to reduce 2 flood risk . 3

16 Increased river flood frequency is considered a major risk under climate change. Protecting 17 vulnerable communities is, therefore, a key public policy objective. Natural flood 18 management measures (NFM) notably re-afforestation on hillslope and floodplain are 19 increasingly discussed as cost-effective means for providing flood regulation, particularly 20 when considering ecosystem services other than flood regulation. However, studies that 21 place flood benefits alongside other benefits are rare, potentially causing uncertainty in 22 policy decision-making. 23 This paper provides a cost-benefit analysis of the impacts of afforestation on peak river flows 24 under UKCP09 climate change projections, and on additional ecosystem services in a rural 25
The secretion of bioactive IL‐1β is primarily controlled by the activation of caspase‐1 through the assembly of inflammasomes formed by NOD‐like receptor family pyrin

Inflammation has been implicated in the pathogenesis of type 2 diabetes (T2D), which is a progressive disease characterized by pancreatic β‐cell dysfunction and apoptosis with consequential insufficient insulin secretion. Autophagy is necessary to maintain the structure, mass and function of pancreatic β‐cells. The present study investigated the crosstalk between autophagy and inflammasome activation in T2D. INS‐1 cells were stimulated with lipopolysaccharide. Apoptosis and reactive oxygen species (ROS) formation were measured using flow cytometry, and cell proliferation was measured using Cell Counting Kit‐8 solution. Autophagy was assayed using western blotting and transmission electron microscopy. The expression levels of interleukin‐1β (IL‐1β) and caspase‐1 were detected by western blotting. The results demonstrated that inhibiting autophagy using 3‐methyladenine (3‐MA) promoted INS‐1 cell apoptosis. This response was correlated with an increase in ROS production and the inflammatory response, including IL‐1β maturation and caspase‐1 activation. Furthermore, when ROS were inhibited using N‐acetyl‐L‐cysteine, inflammation was decreased. These results demonstrated that inhibition of autophagy enhanced inflammatory injury via the ROS‐mediated activation of the Nod‐like receptor pyrin domain‐containing protein 3 inflammasome. Autophagy may have a protective effect by mitigating inflammation in T2D, which may provide a novel approach for T2D treatment.
IMPROVING DEEP LEARNING BASED SEMANTIC SEGMENTATION WITH MULTI VIEW OUTLIER CORRECTION

Abstract. The goal of this paper is to use transfer learning for semi supervised semantic segmentation in 2D images: given a pretrained deep convolutional network (DCNN), our aim is to adapt it to a new camera-sensor system by enforcing predictions to be consistent for the same object in space. This is enabled by projecting 3D object points into multi-view 2D images. Since every 3D object point is usually mapped to a number of 2D images, each of which undergoes a pixelwise classification using the pretrained DCNN, we obtain a number of predictions (labels) for the same object point. This makes it possible to detect and correct outlier predictions. Ultimately, we retrain the DCNN on the corrected dataset in order to adapt the network to the new input data. We demonstrate the effectiveness of our approach on a mobile mapping dataset containing over 10’000 images and more than 1 billion 3D points. Moreover, we manually annotated a subset of the mobile mapping images and show that we were able to rise the mean intersection over union (mIoU) by approximately 10% with Deeplabv3+, using our approach.
MorphoSys

Distributed database systems are widely used to meet the demands of storing and managing computation-heavy workloads. To boost performance and minimize resource and data contention, these systems require selecting a distributed physical design that determines where to place data, and which data items to replicate and partition. Deciding on a physical design is difficult as each choice poses a trade-off in the design space, and a poor choice can significantly degrade performance. Current design decisions are typically static and cannot adapt to workload changes or are unable to combine multiple design choices such as data replication and data partitioning integrally. This paper presents MorphoSys, a distributed database system that dynamically chooses, and alters, its physical design based on the workload. MorphoSys makes integrated design decisions for all of the data partitioning, replication and placement decisions on-the-fly using a learned cost model. MorphoSys provides efficient transaction execution in the face of design changes via a novel concurrency control and update propagation scheme. Our experimental evaluation, using several benchmark workloads and state-of-the-art comparison systems, shows that MorphoSys delivers excellent system performance through effective and efficient physical designs.
The Pathogenesis of Renal Angiomyolipoma: Alternatives to the Perivascular Epithelioid Cell

Although the perivascular epithelioid cell has been proposed and widely accepted as the precursor to renal angiomyolipoma, a normal perivascular epithelioid cell has never been identified, casting doubt on this concept. Nine archived cases of renal angiomyolipoma were examined with routine and immunohistochemical stains. Particular attention was given to small microscopic lesions of angiomyolipoma which were found in association with larger macroscopic tumor nodules. Evaluation of these cases and review of the literature led to the proposal of 4 pathogenetic routes of renal angiomyolipoma development with 4 well described and recognizable precursor cells. It is noted that these are not mutually exclusive routes of pathogenesis and more than one may occur concurrently. The 4 proposed precursor cells are: 1) the renal capsular smooth muscle cells, particularly in cases referred to as renal “capsuloma”, 2) the glomerular mesangial cell in cases of intraglomerular angiomyolipoma, 3) renal tubular epithelial cells via epithelial to mesenchymal transition, and in particular epithelial to pericytic transition, and 4) the renal interstitial vascular associated pericyte with a proliferative phase and transition to angiomyolipoma.
emporal trends in the retention of BVD+ calves and associated nimal and herd-level risk factors during the compulsory eradication rogramme in Ireland

The national BVD eradication programme in Ireland started on a voluntary basis in 2012, becoming compulsory in 2013. The programme relies on accurate identification and prompt removal of BVD+ calves. However, a minority of herd owners have chosen to retain BVD+ animals (defined as still being alive more than seven weeks after the date of the initial test), typically with a view to fattening them to obtain some salvage value. During each year of the programme, additional measures have been introduced and implemented to encourage prompt removal of BVD+ animals. The objective of this study was to describe temporal trends in the retention of BVD+ calves and associated animal and herd-level risk factors during the first three years of the compulsory eradication programme in Ireland. The study population included all BVD+ calves born in Ireland in 2013–2015. A parametric survival model was developed to model the time from the initial BVD test until the animal was slaughtered/died on farm or until 31 December 2015 (whichever was earlier). A total of 29,504 BVD+ animals, from 13,917 herds, were included in the study. The proportion of BVD+ animals that were removed from the herd within 7 weeks of the initial test date increased from 43.7% in 2013 to 70.3% in 2015. BVD+ animals born in 2015 had a much lower survival time (median = 33 days) compared to the 2013 birth cohort (median = 62 days), with a year on year reduction in survival of BVD+ calves. In the initial parametric survival models, all interactions with herd type were significant. Therefore, separate models were developed for beef and dairy herds. Overall the results of the survival models were similar, with birth year, BVD+ status, herd size, county of birth and birth month consistently identified as risk factors independent of herd type (beef or dairy) or the numbers of BVD+ animals (single or multiple) in the herd. In addition, the presence of a registered mobile telephone number was identified as a risk factor in all models except for dairy herds with a single BVD+, while the sex of the BVD+ calf was only identified as a risk factor in this model. Significant progress has been made in addressing the issue of retention of BVD+ calves, however, there is a need for further improvement. A number of risk factors associated with retention have been identified suggesting areas where future efforts can be addressed. © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND
Business Model Innovation in Established SMEs: A Configurational Approach

Small and medium-sized enterprises (SMEs) are at the heart of a nation’s wealth creation, employment generation and economic development. To help SMEs stay competitive in a fast-changing environment, researchers have recently emphasized the relevance of business model innovation (BMI). However, BMI and its performance are not linear but rather a complex phenomenon that depends on contingency factors. Based on configurational theory, this study extends the BMI research to SMEs, exploring the management approaches and BMI capabilities that foster BMI in established SMEs. To achieve this objective, this study of a purposive sample of 78 Spanish SMEs adopts the fuzzy set qualitative comparative analysis (fsQCA) method. Results suggest three substantive conclusions. First, long-term managerial orientation is a key factor for the development of BMI in SMEs. Second, five BMI capabilities (sensing customer needs, sensing technological options, conceptualizing and experimenting, collaborating and BMI strategy) support, in combination with the management approach, the development of BMI in established SMEs. Third, open innovation (open flows of knowledge regarding market needs and the potential of technologies, as well as collaboration with customers) are concrete preconditions of business model innovation. Therefore, managers in SMEs need both to actively consider their management approach towards BMI, and to develop some key dynamic capabilities in their organizations to implement BMI, an approach also valid for post-Covid-19 management.
Incremental Flow Analysis through Computational Dependency Reification

Static analyses are used to gain more confidence in changes made by developers. To be of most use, such analyses must deliver feedback fast. Therefore, incremental static analyses update previous results rather than entirely recompute them. This reduces the analysis time upon a program change, and makes the analysis well-suited for environments where the code base is frequently updated, such as in IDEs and CI pipelines.In this work, we present a general approach to render a modular static analysis for highly dynamic programs incremental, by exploiting dependencies between intermediate analysis results. Modular analyses divide a program in interdependent parts that are analysed in isolation. The dependencies between these parts stem, for example, from the use of shared variables within the program. Our incrementalisation approach leverages the modularity of the analysis together with the dependencies that it reifies to compute and bound the impact of changes. This way, only the affected parts of the result need to be reanalysed, and unnecessary recomputations are avoided.We apply our approach to both a function-modular and a thread-modular analysis and evaluate it by comparing an incremental update of an existing result to a full reanalysis. We find reductions of the analysis time from 6% to 99% on 14 out of 16 benchmark programs, and on most programs the impact on precision is limited. On 7 of the programs, reanalysis time is reduced by more than 75%, showing that our approach results in fast incremental updates.
DO RESILIENT ORGANIZATIONS ENHANCE ORGANIZATIONAL PERFORMANCE?

The economic crisis of 2008 and the Ebola outbreak in 2014 sent massive disruptive shocks across the healthcare systems. The concept of resilience has been studied for a while now and has been applied to various sectors. It was only after the Ebola epidemic that the vulnerability of healthcare systems has gained importance. In today’s uncertain environment, organizations must respond and adapt quickly in order to maintain the sustainability of their businesses. Organizations need to be resilient. The purpose of this paper is to study how resilient organizations impact the organizational performance. The sample for the study consisted of 100 doctors from six hospitals from the list of ADR Monitoring Centre’s of pharmacovigilance programme of India in the state of Himachal Pradesh. The results of the study revealed that the organizational performance is positively and significantly associated with organizational resilience.
Fuzzy Control Of A Mobile Robot In A Dynamic Environment

: In this paper, a fuzzy control system is proposed to making intelligent the movement of a robot in a dynamic environment. We use a Kalman filter in order to determine the position of moving obstacle relative to the position of the robot at any moment. Our intelligent robot is able to change speed and direction of its movement at any moment, depending on the position of obstacle and the position of the target. Eventually, the simulation results confirm the system performance using MATLAB software.
Faecal microbiota transplants and microbial ecosystem therapeutics as a treatment for recurrent Clostridium difficile infections

His pathogenesis seems to be related to perturbations of the intestinal microbiota, caused mainly by broad spectrum antibiotics altering the balance of microbial populations, allowing the pathogen grow and infect.3 It can be contracted by eating vegetative cells or spores. During the passage through the stomach most viable cells die, but spores persist, germinate in the small intestine, and multiply in the colon. The intestinal mucosa promotes the adhesion of C. difficile to the epithelium, where it produces enzymes and A and B toxins, responsible for causing severe inflammation, tissue degradation, watery diarrhoea and pseudomembranous colitis.4
Environmentally Induced Color Polymorphism in Caterpillars of Biston betulavia lognataria

A developmental color polymorphism occurs in the larvae of Biston betularia cognataria, the American subspecies of the peppered moth. These larvae derive protection from predators by resembling twigs of the food plants on which they feed. They range in color from bright green to dark brown affording them an opportunity to utilize many types of food plants and still benefit by imitating the color of the plant's twigs. This study is an attempt to determine the environmental cue or cues which induce the development of body color in the larvae. By manipulating diet and background colors, it was shown that visual cues are the major factors determining caterpillars' body colors, and that diet is a minor contributing factor.
CANADIAN JOURNAL of EXPLORATION GEOPHYSlCS | June 2014

Deconvolution is a process that is normally applied to seismic data before migration to enhance the resolution. We propose that deconvolution should also be applied to the data after a poststack or a prestack migration. We address the objections to this process, then present arguments for its use. The deconvolution process should be applied as a multidimensional process to the complete data. However, a typical trace process is usually sufficient to provide a significant enhancement in the resolution after migration. Two data examples are provided that show significant improvement in the resolution of the data by use of a simple spiking deconvolution that was applied to each trace after migration. Review of seismic basics The movement of the wavelet Consider a zero-offset geophysical model where a wavelet is stationary and assumed to be defined by the source. The zerooffset raypaths are normal to the reflectors. The reflection energy is plotted below the source/receiver location to form a seismic section, even when coming from a dipping reflector, as illustrated in Figure 1a. The reflection events on the section (b) will contain the same wavelet, independent of the dip, and will have the same frequency content. After migration, these wavelets are “rotated” back to the geological location. Deconvolution of the data in (b) will maintain the same resolution of the wavelet in both events after migration. The resolution of the two reflections is compared before and after a poststack migration in Figure 2. The seismic data before migration in Figure 2a has a horizontal reflection and a dipping reflection with dip a. After migration the horizontal event remains the same, but the dipping reflector in Figure 2b has a dip b as related by the migrator’s equation tan a = sinb. The black circles in Figure 2a identify the distances between the wavelet minima when measured vertically along the trace, and are used to represent the vertical resolution. The black dashed circle has the same diameter and represents the same wavelet on the vertical traces of the dipping event. It is compared to the smaller diameter blue circle that is measured normal to the dipping event. The resolution of the dipping event, when measured normal to the dip is higher than the horizontal event. After migration, the same black circles are shown in Figure 2b, illustrating the resolution of the horizontal event after migration remains the same. The resolution of the dipping reflector, when measured normal to the reflector, is now the same as the horizontal reflector. The red wavelet is identical to the vertical wavelets in Figure 2a. The green circle represents the new lower wavelength of the dipping event when measured vertical along a trace. The lower frequency in a vertical trace is a natural part of the migration process that prevents aliasing of the dipping event. It is curious to note that the actual resolution of the dipping event is greater than the horizontal event before migration, but the same after migration.
THE OCCURRENCE OF AMNESIC SHELLFISH POISONS IN SHELLFISH FROM SCOTTISH WATERS

Monitoring for amnesic shellfish poisons in wild and cultivated shellfish from Scottish waters commenced in 1998, following the introduction of revised legislation from the European Community. The principle toxic compound, domoic acid (DA), was detected in a variety of species, in some instances at concentrations above the regulatory limit. Although some harvesting closures were implemented in 1998, DA caused significant problems the following year. In 1999, the majority of scallop (Pecten maximus) fïsheries from the Scottish West Coast were ciosed due to DA, resulting in considerable media attention and speculation on the role of nutrient inputs from local aquaculture. This paper Will present data summarising the principal features of the 1999 toxic event.
The Ecological Relationships of Afroalpine Rodents

Rodents are important biological indicators of the Afroalpine ecosystem. We studied how livestock grazing influenced rodent species richness and abundance among three plant community types (grassland, shrubland and mixed meadow) managed with or without grazing at Borena Sayint National Park. We used Sherman live traps and the Capture-Mark-Recapture method to estimate rodent population density. Then, we identified microhabitat factors influencing rodent density and factors impacted by livestock grazing. In total, 2311 individual small mammals were captured in a total of 4500 trap nights. Of these, 57.6% were trapped in areas of ungrazed land use. Lophuromy flavopunctatus, Arvicanthis abyssinicus and Stenocephalemys griseicauda were the rodent species whereas Crocidura flavescens and Crocidura fumosa were the shrew species captured in the area. The presence of Tachyoryctes splendens and Otomys typus were also evidenced indirectly. The total catch and relative abundance were highest for L. flavopunctatus (50.8%) and least for C. fumosa (0.91%). More small mammals were trapped in the mixed meadow habitat, followed by the ‘guassa’ grassland and ‘charranfe’ heath. The average rodent density across the study area was 65 individuals per hectare, significantly higher (P=0.0002) in areas of ungrazed land use compared to grazed land. Rodent population density per hectare correlated positively to the Afroalpine vegetation cover percentage and negatively to the total livestock signs present in the area. Overall, since livestock grazing reduced the ground vegetation cover percentage, our results underline the importance of careful grazing management to avoid a potential loss in rodent species and overall Afroalpine biodiversity.
Aspects of Phenolic Compounds in Pharmacological Activities of Solanum Family

Solanum family of plants is a large genus under the family of Solanaceae that includes up to 2,000 species, they specify from food crops, such as the potato and the tomato, to various ornamentals and medicinal species. Natural phenolic compounds mostly obtained from solanum species and play an important role in antimicrobial and antibacterial and other treatment. Phenolic compounds from solanaceae plants and dietary plants that contains grains, nut, seeds, legumes and fruits include various phenolic acids, flavonoids, tannins, stilbenes, curcuminoids, coumarins, lignans, quinines like (They divided phenolics biolin four groups analyzing individual compounds: hydroxycinnamic acids (chlorogenic, ferulic, caffeic, and p-coumaric), flavonols (quercetine-3-rutinoside, quercetine-3-galactoside, quercetine-3-glucoside and quercetine-3-rhamnoside), flavanols (catechin and epicatechin) and anthocyanins). I also reviewed several of plants they from solanum species exist the antimicrobial activity due to their phenolic compounds.