Miracle-dz/UniFAR-FTUs huggingface dataset:
Innovation in Social Entrepreneurship: How Social Enterprises Innovate in Their Organization

We examined how social enterprises are innovative in their organization, in order to pursue their mission and remain sustainable in the long-term. With the objective to investigate the innovation in social entrepreneurship, in the component organization, it was developed research of social enterprises, regardless of their location - worldwide - and made a selection (taking into account their activity, size and relevance). Thereafter, it was constituted a database, and a questionnaire, tested, and placed to nearly 1,300 social enterprises of various sizes and parts of the globe, having been received 254 responses that resulted in 106 validated responses, which were considered for the later stages of this work. Research and study of the most relevant theory were performed. In what concerns to innovation in the organization, we find the following performance in terms of respondents who agree moderately, very or completely that their social enterprises innovate: in the form of organization, 54%; in the methodology to encourage volunteers, 64%; in the training plan, 73%; in the motivation plan, 48%; in the compensation and incentives plan, 49%; and in the model to support communities, 78%. The data point to less innovation in the form of organization, in the compensation and incentives plan, and in the motivation plan.
mTOR inhibitors and risk of chronic antibody‐mediated rejection after kidney transplantation: where are we now?

Antibody‐mediated rejection (AMR) usually starts with generation of donor‐specific anti‐HLA antibodies (DSAs), arising from a B‐cell response to antigen recognition. In vitro and preclinical data demonstrate that mammalian target of rapamycin (mTOR) inhibition attenuates the mTOR‐mediated intracellular signaling pathway involved in AMR‐related kidney damage. The limited available data from immunological studies in kidney transplant patients, however, have not shown such effects in vivo. In terms of clinical immunosuppression, the overriding influence on rates of de novo DSA (dnDSA) or AMR—regardless of the type of regimen—is patient adherence. To date, limited data from patients given mTOR inhibitor therapy with adequate concurrent immunosuppression, such as reduced‐exposure calcineurin inhibitor (CNI) therapy, have not shown an adverse effect on the risk of dnDSA or AMR. Early switch to an mTOR inhibitor (<6–12 months post‐transplant) in a CNI‐free regimen, in contrast, can increase the risk of dnDSA, especially if adjunctive therapy is inadequate. Late conversion to CNI‐free therapy with mTOR inhibition does not appear to affect the risk of dnDSA. More data, from prospective studies, are required to fully understand that association between use of mTOR inhibitors with different types of concomitant therapy and risk of dnDSA and AMR.
Cycling and Running Performance, Not Anthropometric Factors, are Associated with Race Performance in a Triple Iron Triathlon

Sixteen well-trained and well-experienced male Caucasian triathletes participated in World Championship Triple Iron Triathlon 2006 in Moosburg, Kärnten, Austria, which required athletes to perform 11.6 km swimming, 540 km cycling, and 126.6 km running within a time limit of 58 hours. Body mass, body height, skinfold thicknesses, circumferences of extremities, skeletal muscle mass, and body fat were measured. The results showed that race time was not significantly influenced by the anthropometric properties (p > 0.05). No significant influence was observed between race time and the calculated parameters of body mass index (BMI), body fat, and skeletal muscle mass (p > 0.05). In contrast, cycling performance (r2 = 0.49, p < 0.01) and running performance (r2 = 0.73, p < 0.01) are associated with total race performance. It summery, in an ultratriathlon, BMI, body height, skinfold thicknesses, circumference of extremities, skeletal muscle mass, and body fat have no influence on race performance in world-class ultratriathletes. Total race performance is associated with performance in cycling and running, not in swimming.
Group Exposure for Agoraphobics: A Replication Study

Summary A replication study was conducted of the treatment of agoraphobics by exposure in cohesive groups, as described by Hand, Lamontagne and Marks (1974). The continuing improvement during follow-up, with consequent large overall improvement, reported in the original study was not replicated. However, the present study confirmed the usefulness of this procedure as a highly cost-efficient treatment. The assumed equivalence of the Gelder and Marks (1966) phobic rating scale and its modification by Watson and Marks (1971) was examined. Large discrepancies between the scales were obtained for initial assessments and change scores. It is suggested that there is a need for workers in this field to agree on methods of measurement.
Intravenous immunoglobulin therapy in the treatment of BK viremia and nephropathy in pediatric renal transplant recipients

Anyaegbu EI, Almond PS, Milligan T, Allen WR, Gharaybeh S, Al‐Akash SI. Intravenous immunoglobulin therapy in the treatment of BK viremia and nephropathy in pediatric renal transplant recipients. Pediatr Transplantation 2012: 16: E19–E24. © 2010 John Wiley & Sons A/S.
Universal health coverage measurement in a low-income context: An Ethiopian case study.

The objective of this case study was to analyze Ethiopias approach to monitoring progress towards universal health coverage (UHC) and consider the implications of Ethiopias experience with UHC measurement for other low-income countries and the international community. The study achieved this objective by (i) exploring indicators that Ethiopia is already using to measure progress towards UHC; (ii) evaluating Ethiopias institutional capacity to collect data for and generate a set of proposed UHC indicators; and (iii) providing recommendations based on findings. (Excerpt)
Regional differences in Finland in the prevalence of rheumatoid factor in the presence and absence of arthritis

Objectives: To look for possible regional differences in the prevalence of rheumatoid factor (RF) in the presence and absence of arthritis. Methods: The study covered a representative sample of the Finnish population aged 30 years or over, primarily comprising 8000 people, of whom 7217 participated in the field survey carried out in 1978–80. RF from serum samples from 7116 subjects was determined by the Waaler-Rose (sensitised sheep cell agglutination) test. Titres ≥32 were regarded as positive and titres ≥128 as strongly positive. Arthritis was diagnosed by a thorough clinical examination. Results: In the absence of arthritis the prevalence of positive and strongly positive RF reactions was 2.1% and 1.0%, respectively. The lowest prevalence of strongly “false positive” RF occurred in south western Finland. After adjustment for age, sex, smoking, and coffee consumption the odds ratio of having a strongly “false positive” RF reaction in eastern Finland was 3.16 (95% confidence interval 1.29 to 7.72) and in northern Finland 2.94 (1.13 to 7.64) compared with south western Finland. The corresponding odds ratio of strongly RF positive arthritis in eastern Finland was 5.08 (1.41 to 18.27). Conclusion: Regional differences are found in the prevalence of a strongly positive RF reaction in the Finnish population. The findings are in accordance with recent results from another study concerning regional differences in the incidence of rheumatoid arthritis in Finland.
Kursreaktionen auf steuerlich veranlasste Sonderausschüttungen – Die Auskehrung von EK 56 im Jahre 1994

Im Jahre 1994 konnten deutsche Kapitalgesellschaften mit der Auskehrung von in vorausgegangenen Jahren voll versteuerten Gewinnr cklagen eine erhebliche Steuerersparnis erzielen; dabei war es aus steuerlicher Sicht unerheblich, ob diese Auskehrung ber eine echte Aussch ttung oder ber ein liquidit tsneutrales Sch tt-aus-hol-zur ck-Verfahren realisiert wurde. Die f r diese Steuerersparnis urs chlichen Rahmenbedingungen sowie deren H he werden im theoretischen Teil dieses Beitrags ausf hrlich analysiert. Der zweite, empirische Teil (IV) besch ftigt sich mit der Frage, inwieweit die an der B rse festzustellenden Kursreaktionen auf die Ank ndigung solcher Sonderaussch ttungen allein auf die steuerliche Entlastung zur ckgef hrt werden k nnen oder ob auch noch andere Effekte im Spiel gewesen sein m ssen. Es zeigt sich, dass der an den Kurseffekten gemessene Verm genszuwachs der Aktion re das 2,6fache der reinen Steuerersparnis betr gt; dabei liegt dieser Faktor bei jenen Unternehmen, die die Aussch ttung voll zu Lasten der eigenen Liquidit t durchgef hrt haben, bei 3,8, w hrend er bei jenen Unternehmen, die sich f r ein Sch tt-aus-hol-zur ck-Verfahren entschieden haben, nur bei 2,1 liegt. Wenngleich diese Differenz im statistischen Sinne nicht signifikant ist, gibt sie Anlass zur Vermutung, dass die Ursache f r den steuerlich nicht erkl rbaren Teil der Kurseffekte in einem Kontrolldefizit in der Beziehung zwischen Management und Aktion r zu suchen ist. Unabh ngig davon wirft der mit der Mobilisierung von R cklagen f r die Aktion re geschaffene Mehrwert ein u erst kritisches Licht auf jene Vorst nde und Aufsichtsr te, die sich trotz erheblicher Steuereinsparungsm glichkeiten zu keiner Sonderaussch ttung aus EK 56 im Jahre 1994 durchringen konnten. Inhalts bersicht
Nowcasting sales growth of manufacturing companies in India

ABSTRACT The performance of private corporate sector is used as an important demand indicator for monetary policy making. As these data are received with a lag, assessing and monitoring of corporate sales on a real-time basis poses a significant challenge to policy makers in India. In this context, this article attempts to nowcast quarterly sales growth of Indian manufacturing companies and GDP growth of India using dynamic factor modelling framework. A multiple-level framework through turning point analysis and elastic net structure is used to overcome the overfitting problem during variable selection. Empirical results show improvement in forecast accuracy for one quarter ahead nowcast using 3-factor and 4-factor models over the benchmark model. However, absolute dominance of 3-factor models over 4-factor models was not established. As such, the article has proposed a forecast combination technique to nowcast sales growth of manufacturing companies in India.
PURPOSEFUL HISPANIC-SERVING INSTITUTION IDENTITY FORMATION FOR LATINO STUDENT SUCCESS: A Conceptual Model and Plan to Create a Culture Supporting Latino Student Success at a Predominantly White Community College Planning to become a Hispanic-Serving Institution

PURPOSEFUL HISPANIC-SERVING INSTITUTION IDENTITY FORMATION FOR LATINO STUDENT SUCCESS: A Conceptual Model and Plan to Create a Culture Supporting Latino Student Success at a Predominantly White Community College Planning to become a Hispanic-Serving Institution Laura Flores Cailloux Chair of the Supervisory Committee: Dr. Joe Lott, Assistant Professor, College of Education This study and practical application is intended to provide institutional guidance in the absence of direct research findings about creating an effective institutional culture at a predominantly White community college transitioning to a Hispanic-Serving Institution (HSI). Many higher education institutions in the United States are on the verge of HSI designation based on demographic shifts in student body composition, but becoming an HSI does not guarantee an institution is ready to support Latino student success in terms of equitable educational attainment (F. Contreras, Malcom, & Bensimon, 2008). Since the literature is nearly silent on institutional cultures which support Latino student success in any higher education context, this research will attempt to bridge the gap between what is known about Latina/o student retention and persistence at the community college and a conceptual model of a supportive institutional culture with the practical outcome of a plan for institutional change. Qualitative research on Latina/o student achievement at community colleges was analyzed utilizing thematic synthesis to develop a conceptual model of Latina/o community college student success. From these themes a conceptual model of institutional culture supportive of Latina/o student success is proposed as well as a planning process to facilitate rethinking the organizational culture to better support Latina/o students.
Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men.

CONTEXT A reliable form of androgen substitution therapy regarding kinetics, tolerance, and restoration of androgenicity is paramount in hypogonadal men. Intramuscular injection of the long-acting ester testosterone undecanoate (TU) offers a new modality. OBJECTIVE The objective of the study was to assess the safety of TU regarding metabolic and pharmacogenetic confounders. DESIGN This was a longitudinal one-arm open observation trial. A minimum of five individual assessments was a prerequisite. Putative modulators of safety parameters entering regression models were nadir and/or delta total testosterone concentrations, body mass index, androgen receptor (AR) gene CAG repeat length, and age. SETTING The study was conducted at an andrological outpatient clinic. PATIENTS Patients included 66 hypogonadal men (mean age 38 +/- 9.9 yr). MAIN OUTCOME MEASURES A total of 515 data time points each related to prostate, erythropoiesis, lipoproteins, and circulation during 118 treatment-years with 1000 mg TU at 10- to 14-wk intervals. RESULTS Testosterone substitution resulted in significant decrements of serum levels of low-density lipoprotein-cholesterol, resting diastolic and systolic blood pressure, and heart rate. Erythropoiesis was stimulated and concentrations of high-density lipoproteincholesterol increased. Parameters remained stable after four injections. No adverse effects regarding the prostate were observed. Significantly increased hematocrit greater than 50% was predicted by enhanced androgen action (shorter AR CAG repeats per higher testosterone levels). However, insufficient androgen action (longer AR CAG repeats per lower testosterone levels) caused pathological safety parameters (high blood pressure, adverse lipid profiles). In addition, a body mass index 30 kg/m(2) or greater represents a clinically relevant factor for the occurrence of all pathological safety parameters. Risk calculations for obese patients and nonlinear pharmacogenetic models to tailor androgen substitution are presented. CONCLUSIONS Testosterone substitution with im TU is generally well tolerated. Modifications of androgen action are due to both AR CAG repeats and testosterone levels. Adverse observations are mostly seen in obese patients.
Research on Risk Assessment of International Factoring Financing Business: Illustrated by the Example of Bank A Zhejiang Branch

This thesis studies on the international factoring financing business of Bank A Zhejiang Branch. It reviews the course of concentrated outbreak and responses of risks since 2012, and by taking the examples of two typical risk events, reveals the decision making process of risk control measures and the deficiencies existing in practice, which leads to the predicament of the business. Then it brings up the question of how to do a good job in the risk assessment of international factoring financing business. Based on the case content, this thesis, introduces the eight management elements in the COSO enterprise risk management framework as theoretical basis, analyzing the item identification and risk assessment on the international factoring business matters of Bank A. With the above overall analysis, this thesis proposes to improve risk assessment efficiency by using COSO enterprise management framework and asymmetric theory.
Randomised controlled trial evaluation of Tweet2Quit: a social network quit-smoking intervention

Background We evaluated a novel Twitter-delivered intervention for smoking cessation, Tweet2Quit, which sends daily, automated communications to small, private, self-help groups to encourage high-quality, online, peer-to-peer discussions. Design A 2-group randomised controlled trial assessed the net benefit of adding a Tweet2Quit support group to a usual care control condition of nicotine patches and a cessation website. Participants Participants were 160 smokers (4 cohorts of 40/cohort), aged 18–59 years, who intended to quit smoking, used Facebook daily, texted weekly, and had mobile phones with unlimited texting. Intervention All participants received 56 days of nicotine patches, emails with links to the smokefree.gov cessation website, and instructions to set a quit date within 7 days. Additionally, Tweet2Quit participants were enrolled in 20-person, 100-day Twitter groups, and received daily discussion topics via Twitter, and daily engagement feedback via text. Measures The primary outcome was sustained abstinence at 7, 30 and 60 days post-quit date. Results Participants (mean age 35.7 years, 26.3% male, 31.2% college degree, 88.7% Caucasian) averaged 18.0 (SD=8.2) cigarettes per day and 16.8 (SD=9.8) years of smoking. Participants randomised to Tweet2Quit averaged 58.8 tweets/participant and the average tweeting duration was 47.4 days/participant. Tweet2Quit doubled sustained abstinence out to 60 days follow-up (40.0%, 26/65) versus control (20.0%, 14/70), OR=2.67, CI 1.19 to 5.99, p=0.017. Tweeting via phone predicted tweet volume, and tweet volume predicted sustained abstinence (p<0.001). The daily autocommunications caused tweeting spikes accounting for 24.0% of tweets. Conclusions Tweet2Quit was engaging and doubled sustained abstinence. Its low cost and scalability makes it viable as a global cessation treatment. Trial registration number NCT01602536.
β-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression

The retinal pigment epithelium (RPE) consists of a monolayer of cuboidal, pigmented cells that is located between the retina and the choroid. The RPE is vital for growth and function of the vertebrate eye and improper development results in congenital defects, such as microphthalmia or anophthalmia, or a change of cell fate into neural retina called transdifferentiation. The transcription factors microphthalmia-associated transcription factor (Mitf) and orthodenticle homolog 2 (Otx2) are crucial for RPE development and function; however, very little is known about their regulation. Here, by using a Wnt-responsive reporter, we show that the Wnt/β-catenin pathway is activated in the differentiating mouse RPE. Cre-mediated, RPE-specific disruption of β-catenin after the onset of RPE specification causes severe defects, resulting in microphthalmia with coloboma, disturbed lamination, and mislocalization of adherens junction proteins. Uponβ -catenin deletion, the RPE transforms into a multilayered tissue in which the expression of Mitf and Otx2 is downregulated, while retina-specific gene expression is induced, which results in the transdifferentiation of RPE into retina. Chromatin immunoprecipitation (ChIP) and luciferase assays indicate that β-catenin binds near to and activates potential TCF/LEF sites in the Mitf and Otx2 enhancers. We conclude that Wnt/β-catenin signaling is required for differentiation of the RPE by directly regulating the expression of Mitf and Otx2. Our study is the first to show that an extracellular signaling pathway directly regulates the expression of RPE-specific genes such as Mitf and Otx2, and elucidates a new role for the Wnt/β-catenin pathway in organ formation and development.
Poster: Spatial Augmented Reality user interface techniques for room size modeling tasks

This poster presents results of our investigations into using Spatial Augmented Reality (SAR) to improve kitchen design and other interior architecture tasks. We present new user interface techniques for room sized modeling tasks, including cabinet layout, viewing and modifying preset designs, and modifying finishes. These tools and techniques address key user interface issues for spatial augmented reality systems, and we discuss how they can be generalized for other applications. The techniques have been developed in the context of a demonstration application, PimpMyKitchen, which allows architects to design kitchens, working with clients in an interactive SAR environment.
Developmental regulation of planar cell polarity and hair‐bundle morphogenesis in auditory hair cells: lessons from human and mouse genetics

Hearing loss is the most common and costly sensory defect in humans and genetic causes underlie a significant proportion of affected individuals. In mammals, sound is detected by hair cells (HCs) housed in the cochlea of the inner ear, whose function depends on a highly specialized mechanotransduction organelle, the hair bundle. Understanding the factors that regulate the development and functional maturation of the hair bundle is crucial for understanding the pathophysiology of human deafness. Genetic analysis of deafness genes in animal models, together with complementary forward genetic screens and conditional knock‐out mutations in essential genes, have provided great insights into the molecular machinery underpinning hair‐bundle development and function. In this review, we highlight recent advances in our understanding of hair‐bundle morphogenesis, with an emphasis on the molecular pathways governing hair‐bundle polarity and orientation. We next discuss the proteins and structural elements important for hair‐cell mechanotransduction as well as hair‐bundle cohesion and maintenance. In addition, developmental signals thought to regulate tonotopic features of HCs are introduced. Finally, novel approaches that complement classic genetics for studying the molecular etiology of human deafness are presented. WIREs Dev Biol 2016, 5:85–101. doi: 10.1002/wdev.202
Identification of the Anti-angiogenic Site within Vascular Basement Membrane-derived Tumstatin*

Components of vascular basement membrane are involved in regulating angiogenesis. Recently, tumstatin (the NC1 domain of α3 chain of type IV collagen) was identified as possessing anti-angiogenic activity. In the present study, the anti-angiogenic activity of tumstatin was localized to the putative 54–132-amino acid Tum-5 domain, and the activity mediated by αvβ3 integrin interaction in an RGD-independent manner. The recombinant Tum-5 produced inEscherichia coli and Pichia Pastorisspecifically inhibited proliferation and caused apoptosis of endothelial cells with no significant effect on nonendothelial cells. Tum-5 also inhibited tube formation of endothelial cells on Matrigel and induced G1 endothelial cell cycle arrest. Moreover, anti-angiogenic effect of Tum-5 was also examined in vivousing both a Matrigel plug assay in C57BL/6 mice and human prostate cancer (PC-3) xenografts in nude mice. The in vivo results demonstrate that Tum-5 at 1 mg/kg significantly inhibited growth of PC-3 tumors in association with a decrease in CD31 positive vasculature. These in vivo studies also show that, at molar equivalents, human Tum-5 is at least 10-fold more active than human endostatin. In addition, these studies for the first time suggest that through the action of endogenous inhibitors, αvβ3 integrin may also function as a negative regulator of angiogenesis. Taken together, these findings demonstrate that Tum-5, a domain derived from tumstatin, is an effective inhibitor of tumor-associated angiogenesis and a promising candidate for the treatment of cancer.