Miracle-dz/UniFAR-FTUs huggingface dataset:
Business process artefact adaptability approach based on artificial immune systems

Changes in business conditions have forced enterprises to continuously be dynamic and flexible. Recent research has focused on developing adaptive business process management systems. However, those approaches do not take in consideration the business process context execution. On the other hand, modularity concern is a common strategy to a lower application complexity: it results in modules that are easy to maintain, to adapt, and to replace. In this work, each activity of a business process is encapsulated in an entity named artefact. These artefacts have an interface, a function and manual instruction described with very expressive formal languages that manage high level concepts. This study aims to apply artificial immune systems AIS to business process applications making their business process artefacts capable to be adaptive to changes that their environments are faced. We explore how in some ways, stimulus or change in business process execution environment can be considered as an antigen and the business process fragment artefact considered as antibody react to this stimulus.
Value Co-creation through Network IT Alignment: An Empirical Examination in Regional Networks

IT alignment in intra-organizational contexts has been recognized as an important factor of organizational performance. This paper takes up this stance and translates it to the network level. In order to explain the role of IT in value co-creation, a theoretical model investigating the interconnection between IT alignment in inter-organizational networks and collaboration success is being developed. Moreover, the mode of governance is identified as an important antecedent to network IT alignment. An empirical study is conducted including answers from 165 regional network organizations in Germany. The results give support for the assumption that network IT alignment, first, contribute to the value co-creation in interorganizational collaboration, and second, can be better achieved by networks with a centralized governance mode. In doing so, this study contributes to the emerging field that tries to understand the role of IT in the functioning of inter-organizational networks.
Cell context in the control of self-renewal and proliferation regulated by MLL1

Mixed lineage leukemia 1 (MLL1) is a gene that is disrupted by chromosomal translocation characteristically in a large proportion of infant leukemia and also in a fraction of childhood and adult leukemia. MLL1 encodes a chromatin regulatory protein related to the Drosophila Trithorax protein, a well-studied epigenetic factor that functions during development to maintain expression of its target genes. Although tremendous progress has been made understanding the downstream targets of MLL1 fusion oncoproteins and how manipulation of those targets impacts leukemogenesis, very little is known regarding how the initial expression of an MLL1 fusion protein impacts on that cell’s behavior, particularly how the cell cycle is affected. Here, we focused on the function of endogenous MLL1 in the stem and progenitor cell types that are likely to be transformed upon MLL1 translocation. Our studies reveal a differential response of stem or progenitor populations to acute loss of MLL1 on proliferation and survival. These data suggest that the effects of MLL1 fusion oncoproteins will initiate the leukemogenic process differentially depending on the differentiation state of the cell type in which the translocation occurs.
Temporal organization as a therapeutic target

Biological functions occur at many different frequencies, and each has its healthy and pathological ranges, patterns, and properties. Physiology, biochemistry, and behavior are not only organized at the morphological level in cells and organs, but separated or coordinated in time for minimal interference and optimal function. One of the most important temporal frameworks is that of the 24-hour day-night cycle, and its change in day length with season. Robust circadian rhythms are important for mental and physical well-being. Though rhythms have been long neglected as irrelevant (in spite of the high prevalence of sleep disorders in nearly every psychiatric illness), we now have tools to document rhythm disruption and, through better understanding of underlying molecular and physiological mechanisms, to develop therapeutic applications. Light as the major synchronizing agent of the biological clock is becoming a treatment option not only for winter depression but other, nonseasonal forms, as well as an adjunct in optimizing sleep-wake cycles, daytime alertness, cognition, and mood in many neuropsychiatric illnesses. Melatonin is the signal of darkness and promotes sleep onset. Manipulation of sleep (wake therapy, phase advance) has yielded the most rapid, nonpharmacological antidepressant effect known, and combinations (with light, medication) provide long-lasting response. Thus, by analogy, new molecules to augment synchronization or mimic changes occuring during night-time wakefulness may yield novel treatments. This issue on biological rhythms contains articles on a variety of different frequencies not included in the usual definition of chronobiology, but which open up interesting approaches to time and illness.
PROFILING BIOMETRIC CHANGES DURING DISACCOMMODATION IN EMMETROPES AND MYOPES

Se ha observado que, debido a la imposibilidad de relajar la acomodacion rapidamente, se produce un cambio miopico de corta duracion, inmediatamente despues de una actividad en vision proxima. Este fenomeno se conoce como miopia transitoria inducida tras una tarea en vision proxima y se especula que el desenfoque retiniano temporal producido, podria tener un papel importante en el desarrollo o progresion de la miopia. El objetivo de este trabajo se ha centrado en el estudio de los cambios opticos y biometricos que se producen durante una demanda acomodativa y tras la finalizacion de la misma. Para ello se han obtenido medidas en una muestra 29 sujetos jovenes (rango=19-39 anos), de los cuales 14 eran miopes y 15 paraemetropes. Las medidas se realizaron con un biometro basado en la reflectometria optica de baja coherencia que ha permitido determinar las dimensiones de longitud axial (LA), espesor del cristalino (EC) y profundidad de la camara antrior (PCA). Asi mismo se han obtenido medidas de la respuesta acomodativa dinamica mediante un autorefractometro de campo abierto. Los resultados muestran que la diferencia entre los valores de la profundidad de la camara anterior sin presencia de ningun estimulo acomodativo y durante una demanda acomodativa de +4,50D tienen una correlacion significativa (p=0,04) con la longitud axial. Ademas se ha observado que la relajacion de la acomodacion es ligeramente mas lenta en los miopes.
A 6-bit Josephson flash A/D converter with GHz input bandwidth

Edge-triggered periodic comparators based on low-inductance superconducting quantum interference devices (SQUIDs) have been combined with a 5-mV step generator used as a clocked power supply to produce an analog-to-digital (A/D) converter with the widest input bandwidth of which the author is aware. The noise and linearity have been measured to be more than adequate for 6 b. Asynchronous beat frequency tests indicate that the current design is capable of about four effective bits resolution at 5-GHz input bandwidth and 3 b at 10 GHz. The aperture jitter at 6-GHz clock rates has been measured to be 100 fs rms indicating that the intrinsic noise is low enough to permit subpicosecond aperture times in faster designs. Further advantages include tolerance of large critical current variations and a sinewave clock as the only high-speed waveform necessary to drive the circuit. The amplitude and spectral purity of the sinewave are not critical as long as it reaches a threshold value, since it is regulated by the step generator. <<ETX>>
A Lyapunov Function for Economic Optimizing Model Predictive Control

Standard model predictive control (MPC) yields an asymptotically stable steady-state solution using the following procedure. Given a dynamic model, a steady state of interest is selected, a stage cost is defined that measures deviation from this selected steady state, the controller cost function is a summation of this stage cost over a time horizon, and the optimal cost is shown to be a Lyapunov function for the closed-loop system. In this technical note, the stage cost is an arbitrary economic objective, which may not depend on a steady state, and the optimal cost is not a Lyapunov function for the closed-loop system. For a class of nonlinear systems and economic stage costs, this technical note constructs a suitable Lyapunov function, and the optimal steady-state solution of the economic stage cost is an asymptotically stable solution of the closed-loop system under economic MPC. Both finite and infinite horizons are treated. The class of nonlinear systems is defined by satisfaction of a strong duality property of the steady-state problem. This class includes linear systems with convex stage costs, generalizing previous stability results and providing a Lyapunov function for economic MPC or MPC with an unreachable setpoint and a linear model. A nonlinear chemical reactor example is provided illustrating these points.
Effect of Growth Media, pH and Temperature on Yeast to Hyphal Transition in Candida albicans

The transition of C. albicans from unicellular yeast form to filamentous form i.e., pseudohyphae and hyphae is referred to as morphogenesis. C. albicans has the ability to respond to environmental conditions and accordingly changing its cell morphology. Three main morphological forms of C. albicans are unicellular yeast, pseudohyphae and hyphae. The effect of different growth media (Horse serum medium, RPMI-1640, MSGB), incubation temperatures (34°C, 37°C, 40°C) and pH values (5.4, 6.4, 7.4) on germ tube production by C. albicans was evaluated. Horse serum medium noticeably promotes filamentation while RPMI-1640 medium shows moderate filamentation and MSGB media shows moderately low filamentation. The germ tube of C. albicans developed early in 1.5 hr at high temperature i.e., 40°C. Incubation temperature of 37°C was associated with highest germ tube formation while 34°C shows low filamentation. A pH of 5.4 also induces low filamentation, pH 6.4 gives moderately lower than pH 7.4. A pH of 7.4 was best suited for germ tube induction. The peak of mycelium production appears between 1.5 and 6 hr after inoculation of C. albicans culture. These results suggested that environmental factors are important in selectively favoring yeast or hyphal form, most important being the growth medium, incubation temperature and external pH value.
UV SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTITATIVE ESTIMATION OF INDINAVIR SULPHATE IN CAPSULES Original Article

Objective: To develop a simple and cheap UV spectrophotometric method for the quantitative estimation of Indinavir sulphate (400mg) in capsules and validate as per ICH guidelines. Methods: The optimized method uses a diluent 100% potassium dihydrogen ortho phosphate buffer (pH 4.0) for the estimation of assay of Indinavir sulphate whose λmax is 259 nm. Results: The developed method resulted in Indinavir sulphate exhibiting linearity in the range 20-80 μg/ml. The precision is exemplified by relative standard deviation of 1.44%. Percentage Mean recovery was found to be in the range of 98-102, during accuracy studies. The limit of detection (LOD and limit of quantitiation (LOQ) were found to be 14.42 μg/ml and 43.69 μg/ml respectively. Conclusion: A simple and a cheap UV spectrophotometric method was developed and validated for the quantitative estimation of Indinavir sulphate in capsules as per ICH guidelines and hence it can be used for the routine analysis in various pharmaceutical industries.
Distributed Vector Representation Of Shopping Items, The Customer And Shopping Cart To Build A Three Fold Recommendation System

The main idea of this paper is to represent shopping items through vectors because these vectors act as the base for building em- beddings for customers and shopping carts. Also, these vectors are input to the mathematical models that act as either a recommendation engine or help in targeting potential customers. We have used exponential family embeddings as the tool to construct two basic vectors - product embeddings and context vectors. Using the basic vectors, we build combined embeddings, trip embeddings and customer embeddings. Combined embeddings mix linguistic properties of product names with their shopping patterns. The customer embeddings establish an understand- ing of the buying pattern of customers in a group and help in building customer profile. For example a customer profile can represent customers frequently buying pet-food. Identifying such profiles can help us bring out offers and discounts. Similarly, trip embeddings are used to build trip profiles. People happen to buy similar set of products in a trip and hence their trip embeddings can be used to predict the next product they would like to buy. This is a novel technique and the first of its kind to make recommendation using product, trip and customer embeddings.
The Optimal Collection of Seigniorage: Theory and Evidence

This paper presents and tests a positive theory of monetary and fiscal policy. The government chooses the rates of taxation and inflation to minimize the present value of the social cost of raising revenue given exogenous expenditure and an intertemporal budget constraint. The theory implies that nominal interest rates and inflation are random walks. It also implies that nominal interest rates and inflation move together with tax rates. United States data from 1952 to 1985 provide some support for the theory.
Surface modification of graphene nanopores for protein translocation

Studies of DNA translocation through graphene nanopores have revealed their potential for DNA sequencing. Here we report a study of protein translocation through chemically modified graphene nanopores. A transmission electron microscope (TEM) was used to cut nanopores with diameters between 5 and 20 nm in multilayer graphene prepared by chemical vapor deposition (CVD). After oxygen plasma treatment, the dependence of the measured ionic current on salt concentration and pH was consistent with a small surface charge induced by the formation of carboxyl groups. While translocation of gold nanoparticles (10 nm) was readily detected through such treated pores of a larger diameter, translocation of the protein ferritin was not observed either for oxygen plasma treated pores, or for pores modified with mercaptohexadecanoic acid. Ferritin translocation events were reliably observed after the pores were modified with the phospholipid–PEG (DPPE-PEG750) amphiphile. The ion current signature of translocation events was complex, suggesting that a series of interactions between the protein and pores occurs during the process.
Case series: Treatment of large dentigerous cysts in children.

AIM To present a series of clinical cases of children treated for large dentigerous cysts with a conservative and tissue preserving surgical approach. METHODS A follow-up study of 11 children aged 5-11 years old treated for large dentigerous cysts with decompression. The children were followed from the first appointment when the cysts were diagnosed until the full eruption of the involved and displaced teeth. The treatment procedure is described step by step. Three of the 11 cases are presented in detail. RESULTS All permanent teeth displaced by the dentigerous cysts, except a wisdom tooth and a maxillary canine, erupted in a correct position and in good occlusion. No facial disfigurations or defects of oral tissues occurred. CONCLUSIONS A decompression approach, as described in this paper, is rewarding for the patient and the surgeon. It would be unethical and destructive to the maxillofacial bone structure not to treat large dentigerous cysts in children by decompression.
Translation non-negative matrix factorization with fast optimization

Non-negative matrix factorization (NMF) reconstructs the original samples in a lower dimensional space and has been widely used in pattern recognition and data mining because it usually yields sparse representation. Since NMF leads to unsatisfactory reconstruction for the datasets that contain translations of large magnitude, it is required to develop translation NMF (TNMF) to first remove the translation and then conduct a decomposition. However, existing multiplicative update rule based algorithm for TNMF is not efficient enough. In this paper, we reformulate TNMF and show that it can be efficiently solved by using the state-of-the-art solvers such as NeNMF. Experimental results on face image datasets confirm both efficiency and effectiveness of the reformulated TNMF.
Fecal calprotectin in predicting relapse of inflammatory bowel diseases: A meta‐analysis of prospective studies

Background: Fecal calprotectin (FC) is a relatively new marker of intestinal inflammation. Recently, many studies have extended its role in predicting relapse of quiescent inflammatory bowel disease (IBD), but the reported results have been inconsistent. We aimed to perform a meta‐analysis of the predictive capacity of FC in IBD relapse. Methods: We systematically searched the Medline, Web of Science, Cochrane Library, and EMBASE databases for prospective studies that used FC concentrations at remission in predicting relapse of Crohn's disease (CD) and ulcerative colitis (UC). Pooled sensitivity, specificity, and other diagnostic indices were evaluated. Results: A total of 672 IBD patients (318 UC and 354 CD) from six different studies were analyzed. The pooled sensitivity and specificity of FC to predict relapse of quiescent IBD was 78% (95% confidence interval [CI]: 72–83) and 73% (95% CI: 68–77), respectively. The area under the summary receiver‐operating characteristic (sROC) curve was 0.83 and the diagnostic odds ratio was 10.31 (95% CI: 5.05–21.06). The capacity of FC to predict relapse was comparable between UC and CD. In CD patients the predictive value of FC in isolated small bowel CD was not assessed due to insufficiency of available data. Compared with all enrolled CD patients, FC appeared to be more accurate in ileocolonic and colonic CD. Conclusions: As a simple and noninvasive marker, FC is useful to predict relapse in quiescent IBD patients. (Inflamm Bowel Dis 2012)
Angiogenesis and the atherosclerotic carotid plaque: association between symptomatology and plaque morphology

Symptomatic carotid disease due to thromboembolism has been associated with acute plaque instability and intraplaque haemorrhage. These features may be influenced by the fragility and position of plaque neovessels. The purpose of this study was, therefore, to determine whether any association existed between neovessel density, position, morphology and thromboembolic sequelae.
Physiological and urinary metabolite responses to cold shock and confinement of sheep.

Fourteen 15-kg hand-raised lambs were subjected to a control treatment or to one 3-hr, -5 C cold shock each day for 4 days. The greatest increase in heart rate occurred at the second hour of cold shock, when ambient temperatures were lowest. This increase became successively smaller each day. The greatest rectal temperature decreases occurred after 3 hr of cold shock, 1 hr after the minimum ambient temperature had been reached. This rectal temperature decrease became successively greater each day as the lambs habituated to the cold shocks. Urinary calcium excretion was 67% higher (P less than .05) in the cold-shocked lambs than in the controls during the 18-hr intervals following the shock. Urinary cortisol excretion was different only on day 2, when the control group showed higher (P less than .05) values. A confinement stress was induced by the placing of four lambs in metabolic cages 5 days after they were removed from a range environment. These lambs were compared to four other lambs in metabolic cages which had been reared in the laboratory. Confinement stress increased urinary cortisol excretion (P less than .05) above that of the laboratory-reared lambs for the first 3 days. A mean urinary cortisol excretion of 41 ng.MBS-1.mr-1 or 20 ng.mg. creatine-1 was found in lambs in the range and laboratory groups over the remainder of the study. The range lambs' nitrogen retention, measured after cortisol excretion returned to baseline, was greater (P less than .05) than that of the laboratory lambs.
Affective instability as rapid cycling: theoretical and clinical implications for borderline personality and bipolar spectrum disorders.

OBJECTIVES The Diagnostic and Statistical Manual of Mental Disorders guidelines provide only a partial solution to the nosology and treatment of bipolar disorder in that disorders with common symptoms and biological correlates may be categorized separately because of superficial differences related to behavior, life history, and temperament. The relationship is explored between extremely rapid switching forms of bipolar disorder, in which manic and depressive symptoms are either mixed or switch rapidly, and forms of borderline personality disorder in which affective lability is a prominent symptom. METHODS A MedLine search was conducted of articles that focused on rapid cycling in bipolar disorder, emphasizing recent publications (2001-2004). RESULTS Studies examined here suggest a number of points of phenomenological and biological overlap between the affective lability criterion of borderline personality disorder and the extremely rapid cycling bipolar disorders. We propose a model for the development of 'borderline' behaviors on the basis of unstable mood states that sheds light on how the psychological and somatic interventions may be aimed at 'breaking the cycle' of borderline personality disorder development. A review of pharmacologic studies suggests that anticonvulsants may have similar stabilizing effects in both borderline personality disorder and rapid cycling bipolar disorder. CONCLUSIONS The same mechanism may drive both the rapid mood switching in some forms of bipolar disorder and the affective instability of borderline personality disorder and may even be rooted in the same genetic etiology. While continued clinical investigation of the use of anticonvulsants in borderline personality disorder is needed, anticonvulsants may be useful in the treatment of this condition, combined with appropriate psychotherapy.
On coupled regularization for non-convex variational image enhancement

A natural continuation from conventional convex methods for image enhancement is the transition to non-convex formulations. However, strictly non-convex models do not admit traditional tools from convex optimization to be used. To resolve this drawback, non-convex problems are often cast into convex formulations by relaxing stringent assumptions on model properties. In this work we present an alternative approach. We study when an energy functional is convex given a non-convex penalty term. Key to our formulation is the introduction of a novel coupling between the discretization scheme and a non-local weight function in the data term. We interpret the non-local weights for the finite difference operators. In a denoising application we study a class of non-convex ℓp-norms. The resulting energies are globally minimized using the popular ADMM.