Miracle-dz/UniFAR-FTUs huggingface dataset:
Suppression of superoxide anion generation catalyzed by xanthine oxidase with alkyl caffeates and the scavenging activity

Abstract Alkyl caffeates are strong antioxidants and inhibitors of xanthine oxidase. However, it is unclear about the effect of caffeic acid and alkyl caffeates on superoxide anion (O2−) generation catalyzed by xanthine oxidase. Effects of caffeic acid and alkyl caffeates on the uric acid formation and O2− generation catalyzed by xanthine oxidase were analyzed. The scavenging activities of 1,1-diphenyl-2-picryhydrazyl (DPPH) radical and O2− generated with phenazine methosulfate (PMS) and NADH were examined. Caffeic acid derivatives equally suppressed O2− generation, and the suppression is stronger than inhibition of xanthine oxidase. Scavenging activity of O2− is low compared to the suppression of O2− generation. Suppression of O2− generation catalyzed by xanthine oxidase with caffeic acid derivatives was not due to enzyme inhibition or O2− scavenging but due to the reduction of xanthine oxidase molecules. Alkyl caffeates are effective inhibitors of uric acid and O2− catalyzed by xanthine oxidase as well as antioxidants for edible oil.
Saponins: Properties, Applications and Processing

Saponins are a diverse group of compounds widely distributed in the plant kingdom, which are characterized by their structure containing a triterpene or steroid aglycone and one or more sugar chains. Consumer demand for natural products coupled with their physicochemical (surfactant) properties and mounting evidence on their biological activity (such as anticancer and anticholesterol activity) has led to the emergence of saponins as commercially significant compounds with expanding applications in food, cosmetics, and pharmaceutical sectors. The realization of their full commercial potential requires development of new processes/processing strategies to address the processing challenges posed by their complex nature. This review provides an update on the sources, properties, and applications of saponins with special focus on their extraction and purification. Also reviewed is the recent literature on the effect of processing on saponin structure/properties and the extraction and purification of sapogenins.
The acceptance study of NFC technology: A survey of models and user acceptance

As information technology rapidly changes and assimilates into our life seamlessly through the exponential growth of the Internet, identifying related technology acceptance behaviour among users becomes vital. Existing researches have shown that new systems require novice users to spend an amount of time to get to know the technology. Near Field Communication (NFC) is an emerging technology, which offers an enhanced interaction for users by simplifying data transfers, secured payment transaction access and many more. In this paper, we looked into a number of widely used acceptance models such as the Theory of Reasoned Action (TRA), Theory Planned Behavior (TPB) and, the Unified Theory of Acceptance and Use of Technology (UTAUT) to identify the theory that is best suited as an assessment tool of the user acceptance to the NFC technology. We have identified UTAUT as the best tool based on literature and utilized the theory to develop a questionnaire for the user acceptance survey. Our results indicates, factors such as social influence and facilitating condition affected the users' technology acceptance for NFC where most respondents are willing to use the technology if they had the chance to do so.
Spécialisation et sous-typage : thème et variations

Class specialization is the most original feature of object orientation, but identifying it to subtyping leads to the well known covariance-contravariance controversy. Type safety requires contravariance while specialization needs covariance. This paper aims to precisely analyse this problem, to show how irreductible it is and the need for type errors. We show that many alternatives as multiple dispatch, genericity or matching cannot solve the problem. Thus, a realistic solution is to adopt covariant redefinition as the basis of a type system where type errors are explicited, as they should be at the analysis and design stages. MOTS-CLÉS :langage à objets, spécialisation, sous-typage, généricité, héritage, sélection multiple, covariance, contravariance.
The effects of the combination of egg and fiber on appetite, glycemic response and food intake in normal weight adults – a randomized, controlled, crossover trial

Abstract This study evaluated appetite and glycemic effects of egg-based breakfasts, containing high and moderate protein (30 g protein and 20 g protein +7 g fiber, respectively) compared to a low-protein cereal breakfast (10 g protein) examined in healthy adults (N = 48; age 24 ± 1 yr; BMI 23 ± 1 kg/m2; mean ± SE). Meals provided 390 kcal/serving and equal fat content. Food intake was measured at an ad libitum lunch meal and blood glucose response was measured. Visual analog scales (VAS) were used to assess hunger, satisfaction, fullness, and prospective food intake. The egg-based breakfast meal with high protein produced greater overall satiety (p < 0.0001), and both high protein and moderate protein with fiber egg-based breakfasts reduced postprandial glycemic response (p < 0.005) and food intake (p < 0.05) at subsequent meal (by 135 kcal and 69 kcal; effect sizes 0.44 and 0.23, respectively) compared to a cereal-based breakfast with low protein and fiber.
User-friendly walking assistance device able to walk on stairs safely

A novel control method for the walking assistance device using predefined walking trajectory used to walk for the elderly or the patients with weak leg muscle on stairs from plain more safely and naturally is proposed in this paper. Two control method, torque control and impedance control, used per their usage purpose are introduced, and the later one is focused in this paper. To make sure the use of safety, two situations, putting swing leg in front of stair too close or too far, while a user wearing assistance climbing up on the stairs through even ground is considered. If the user faces these situations walking with the apparatus using impedance control, falling or collision between apparatus and stair are happened more easily than level walking because of lots of environment facts need to be considered like the distance between user and stairs. One of the most important environment facts is recognizing of the stairs, therefore, to prevent the user from the danger in each situation, ultrasonic sensor is used as a safety system to keep space, and we called safety distance, between foot part of walking device and stair. The value of safety distance is not only defined as a switch to change the walking trajectory between the plain mode and the stair mode but also used to decide the ideal stride of trajectory while walking to stairs from even ground. Finally, the result of walking experiment shows that the safety walking experience by wearing our walking assistance device can be achieved.
Temperature sensing properties of the passive wireless sensor based on graphene oxide films

This paper presents a passive wireless temperature sensor with graphene oxide (GO) films as the sensing material. In this sensor a temperature sensitive capacitor is used in a LC tank circuit. The resonant frequency of the tank circuit changes with the temperature. The test results imply that the temperature sensor based on graphene oxide films with proper concentration provides a sensitivity of 59.3 kHz /°C from -C40°C to 0 °C and 46.1 kHz /°C from 10°C to 60°C. The relationship between the sensing properties and dispersion concentrations is also studied. The measured results imply that the sensor based on GO films with proper concentration shows monotonic relationship over a certain temperature range between the sensing resonant frequency and temperature.
Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa.

BACKGROUND Behavioral and psychological symptoms in dementia are frequent and are a major management problem, especially for patients with severe cognitive impairment. Preliminary reports have indicated positive effects of aromatherapy using select essential oils, but there are no adequately powered placebo-controlled trials. We conducted a placebo-controlled trial to determine the value of aromatherapy with essential oil of Melissa officinalis (lemon balm) for agitation in people with severe dementia. METHOD Seventy-two people residing in National Health Service (U.K.) care facilities who had clinically significant agitation in the context of severe dementia were randomly assigned to aromatherapy with Melissa essential oil (N = 36) or placebo (sunflower oil) (N = 36). The active treatment or placebo oil was combined with a base lotion and applied to patients' faces and arms twice a day by caregiving staff. Changes in clinically significant agitation (Cohen-Mansfield Agitation Inventory [CMAI]) and quality of life indices (percentage of time spent socially withdrawn and percentage of time engaged in constructive activities, measured with Dementia Care Mapping) were compared between the 2 groups over a 4-week period of treatment. RESULTS Seventy-one patients completed the trial. No significant side effects were observed. Sixty percent (21/35) of the active treatment group and 14% (5/36) of the placebo-treated group experienced a 30% reduction of CMAI score, with an overall improvement in agitation (mean reduction in CMAI score) of 35% in patients receiving Melissa balm essential oil and 11% in those treated with placebo (Mann-Whitney U test; Z = 4.1, p < .0001). Quality of life indices also improved significantly more in people receiving essential balm oil (Mann-Whitney U test; percentage of time spent socially withdrawn: Z = 2.6, p = .005; percentage of time engaged in constructive activities: Z = 3.5, p = .001). CONCLUSION The finding that aromatherapy with essential balm oil is a safe and effective treatment for clinically significant agitation in people with severe dementia, with additional benefits for key quality of life parameters, indicates the need for further controlled trials.
The Shape Space of 3D Botanical Tree Models

We propose an algorithm for generating novel 3D tree model variations from existing ones via geometric and structural blending. Our approach is to treat botanical trees as elements of a tree-shape space equipped with a proper metric that quantifies geometric and structural deformations. Geodesics, or shortest paths under the metric, between two points in the tree-shape space correspond to optimal deformations that align one tree onto another, including the possibility of expanding, adding, or removing branches and parts. Central to our approach is a mechanism for computing correspondences between trees that have different structures and a different number of branches. The ability to compute geodesics and their lengths enables us to compute continuous blending between botanical trees, which, in turn, facilitates statistical analysis, such as the computation of averages of tree structures. We show a variety of 3D tree models generated with our approach from 3D trees exhibiting complex geometric and structural differences. We also demonstrate the application of the framework in reflection symmetry analysis and symmetrization of botanical trees.
PV market in Japan and impacts of grid constriction

Since the start of the Feed-in Tariff Program in July 2012, the PV market in Japan has been growing and annual installed capacity reached 9 GW level in 2014. Approved capacity of PV systems reached about 70 GW as of the end of November 2014. Because of the large approved number, Kyusyu Electric Power Company started suspension of grid connection contract in September 2014. Totaling 7 utility companies out of 10 suspended grid connection contracts, concerning negative impacts of PV power generation. The Ministry of Economy, Trade and Industry (METI) established working group to discuss hosting capacity and measures to introduce more renewable energy. One of the measures is implementation of the curtailment for specific utility companies' areas. This paper describes status of Japanese PV market and discusses impacts of grid issues gives outlook of future PV market in Japan.
Numerical Simulations of MEMS Comb-Drive Using Coupled Mechanical and Electrostatic Analyses

Coupled domain mechanical and electrostatic analysis of MEMS Comb-Drive has been carried out in this study. Numerical simulations are performed using Finite Element Method for Mechanical Analysis and Boundary Element Method for Electrostatic Analysis. Various design parameters of a Comb-Drive like finger overlap, folded flexure spring length and applied voltage were considered and their effect on performance variables like capacitance, natural frequency and displacement of comb were studied using numerical simulations. Simulations were performed using a standard Comb-Drive with 30 movable fingers in the comb and folded flexure spring length varying from 200 μm to 350 μm. The results showed that the capacitance of the Comb-Drive increases with increasing finger-overlap whereas the finger-overlap increases by increasing driving voltage. A relationship between Comb-Drive displacement and the natural frequency of the structure with folded flexure spring length is also comprehensively covered in this study.
Structural Magnetic Resonance Imaging in Established and Prodromal Alzheimer Disease: A Review

Alzheimer disease (AD), the most common form of dementia among the elderly, is currently diagnosed on the basis of clinical criteria that have been in use for many years. When these criteria are applied in tertiary care settings by experienced clinicians, the accuracy of diagnosis in comparison to autopsy findings is 80% to 90%. In primary care settings, the accuracy of diagnosis is considerably lower. Thus, there remains a great need for a definitive test for AD. In addition, there is increasing optimism that medications will be developed that are truly effective at preventing or slowing down the progression of symptoms. Therefore, there is increasing interest in determining whether there are surrogate markers for AD that can be used, either for diagnosis or for measuring disease progression. One potential surrogate marker is magnetic resonance imaging (MRI). This report will give an overview of structural MRI findings in patients with mild to moderate AD, as well as those in the prodromal stage of disease, and will compare the imaging findings to what is known about the pathology of AD that is presumed to underlie the MRI measures. Both cross-sectional and longitudinal studies will be described. The latter are particularly relevant to the potential for using MRI measures as a surrogate marker for progression of disease in clinical trials.
The neurofeedback course using of high skilled gymnasts at competitive period

Strizhkova, O. , Cherapkina, L. & Strizhkova, T. (2014). The neurofeedback course using of high skilled gymnasts at competitive period. J. Hum. Sport Exerc. , 9(Proc1), pp.S561-S569. The research was carried out with 28 high skilled gymnasts (15 ‐ main group, 13 ‐ control group) allowed to define the neurofeedback influence on the functional condition of sportswomen in competitive period. The neurofeedback course promotes improvement of rapidity of complex coordinating motions learning, vestibular stability and self-estimation of functional condition. Also it conducts the alpha-rhythm power increasing at left hemisphere. The neurofeedback course efficiency is defined by index of change of course average alpha-rhythm power with 100% prognostic accuracy. The attention switching, attention stability and self-estimation of sleep and memory are predictors of neurofeedback course successfulness. Key words: EFFICIENCY OF TRAINING, SUCCESSFULNESS OF TRAINING, CEREBRUM BIOELECTRIC ACTIVITY, PREDICTORS OF EFFICIENCY AND SUCCESSFULNESS.
Effect of radiofrequency radiation in cultured mammalian cells: A review

ABSTRACT The use of mobile phone related technologies will continue to increase in the foreseeable future worldwide. This has drawn attention to the probable interaction of radiofrequency electromagnetic radiation with different biological targets. Studies have been conducted on various organisms to evaluate the alleged ill-effect on health. We have therefore attempted to review those work limited to in vitro cultured cells where irradiation conditions were well controlled. Different investigators have studied varied endpoints like DNA damage, cell cycle arrest, reactive oxygen species (ROS) formation, cellular morphology and viability to weigh the genotoxic effect of such radiation by utilizing different frequencies and dose rates under various irradiation conditions that include continuous or pulsed exposures and also amplitude- or frequency-modulated waves. Cells adapt to change in their intra and extracellular environment from different chemical and physical stimuli through organized alterations in gene or protein expression that result in the induction of stress responses. Many studies have focused on such effects for risk estimations. Though the effects of microwave radiation on cells are often not pronounced, some investigators have therefore combined radiofrequency radiation with other physical or chemical agents to observe whether the effects of such agents were augmented or not. Such reports in cultured cellular systems have also included in this review. The findings from different workers have revealed that, effects were dependent on cell type and the endpoint selection. However, contradictory findings were also observed in same cell types with same assay, in such cases the specific absorption rate (SAR) values were significant.
Isolation and Identification of Mycobacterium tuberculosis from AIDS Patients Attending a Rural Hospital in Central India

Aim: To isolate and characterize mycobacterium tuberculosis from clinical samples of AIDS patients. Materials and Methods: This cross -sectional observational study was conducted in department of microbiology, in a rural medical college. The inclusion criteria were adult patient of any sex, HIV seropositive, CD4 counts 200cells/cumm. Complete blood counts and CD4 counts were done. Blood, sputum, stool and other extra-pulmonary samples were processed for mycobacterial isolation. BACTEC 13A medium was used for blood samples while Lowenstein Jensen and BACTEC 12B medium was used for other samples. Smears were examined for all samples other than blood. Identification of the isolates was done by standard techniques. Results: 65% patients were TB symptomatic with cough, fever, breathlessness and loss of weight being significant clinical features. Chest X-rays finding were infiltration and air space consolidation. Cavity was found in only 3% cases. 9 mycobacterium tuberculosis isolates were isolated. Mycobacteria were isolated from various samples viz. sputum (8 M. tuberculosis), blood (1 M. tuberculosis). Conclusion: Mycobacterium tuberculosis is commonly isolated in AIDS patients.
Laboratory study of collisionless coupling between explosive debris plasma and magnetized ambient plasma

The explosive expansion of a localized plasma cloud into a relatively tenuous, magnetized, ambient plasma characterizes a variety of astrophysical and space phenomena. In these rarified environments, collisionless electromagnetic processes rather than Coulomb collisions typically mediate the transfer of momentum and energy from the expanding “debris” plasma to the surrounding ambient plasma. In an effort to better understand the detailed physics of collisionless coupling mechanisms, compliment in situ measurements of space phenomena, and provide validation of previous computational and theoretical work, the present research jointly utilizes the Large Plasma Device and the Raptor laser facility at the University of California, Los Angeles to study the super-Alfvenic, quasi-perpendicular expansion of laser-produced carbon (C) and hydrogen (H) debris plasma through preformed, magnetized helium (He) ambient plasma via a variety of diagnostics, including emission spectroscopy, wavelength-filtered imaging, and .
Boosting Dendritic Cell Vaccination for Glioblastoma Using Tetanus Toxoid.

blocking antibodies or a control antibody. Increased viral replication in TNFa-blocking antibody–treated mice was observed compared with controls. The survival of mice with intracranial GBM xenografts treated with oHSV and TNFa-blocking antibody was significantly better than that of mice treated with oHSV and control antibody. Importantly, there are many already approved TNFa blockers that may be used with oHSV to treat GBM, and clinical studies to test whether TNFa blockers synergize with oHSV anti-GBM therapy are proposed.
Application of high-quality built-in test to industrial designs

This paper presents an approach for high-quality built-in test using a neighborhood pattern generator (NPG). The proposed NPG is practically acceptable because (a) its structure is independent of circuit under test, (b) it requires low area overhead and no performance degradation, and (c) it can encode deterministic test cubes, not only for stuck-at faults but also transition faults, with high probability. Experimental results for large industrial circuits illustrate the efficiency of the proposed approach.
DETERMINAÇÃO DA CAPACIDADE DE CARGA TURÍSTICA A PARTIR DO MÉTODO CIFUENTES ET AL. (1992): Aplicação à Praia dos Carneiros (Tamandaré/PE)

A capacidade de carga surge como um conceito nas areas da ecologia e da demografia. Posteriormente passou a ser utilizada no campo do planejamento turistico como uma maneira de ajudar a desenvolver destinos mais sustentaveis. No entanto, ainda hoje, muitos sao os destinos turisticos que nao utilizam tal ferramenta em seus processos de planejamento. Tamandare, municipio localizado no litoral sul de Pernambuco, nao e excecao. Considerando que o estabelecimento de um limite maximo de usuarios e um elemento que pode auxiliar no ordenamento do turismo, o presente estudo aplicou o metodo desenvolvido por Cifuentes et al. (1992) para estimar a capacidade de carga de uma das principais praias de Tamandare: a Praia dos Carneiros. Para tanto, foram definidas duas zonas: i) zona de faixa de praia e ii) zona de piscinas naturais. Os resultados encontrados sugerem um limite maximo de usuarios de 129 visitantes/ dia para a faixa de praia e de 1.161 visitantes/dia para a zona de piscinas naturais. Quando se comparam os limites sugeridos com as taxas atuais de visitantes, verifica-se que a capacidade de carga esta dentro do aceitavel para a zona de piscinas naturais e acima do recomendado na zona de faixa de praia.
RESETing ER proteostasis: selective stress pathway hidden in the secretory route

The efficient folding of membrane and secreted proteins relies on the unfolded protein response (UPR) to buffer fluctuations in the load of misfolded proteins. Although the UPR is thought to operate on a generic manner to maintain ER proteostasis, a recent study revealed the existence of a novel mechanism to eliminate misfolded GPI‐anchored proteins via the secretory pathway, termed ‘rapid ER stress‐induced export’ (RESET) (Satpute‐Krishnan et al, ). RESET involves the export of misfolded GPI proteins to the plasma membrane for subsequent degradation by the lysosome.