Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of Heparanase-induced Phosphatidylinositol 3-Kinase-AKT Activation and Its Integrin Dependence*

Background: Heparanase levels are associated with tumor metastasis. Latent heparanase induces the prosurvival PI3K-AKT pathway via uncharacterized mechanisms. Results: AKT activation by heparanase involved PI3K p110α, RAS, RICTOR, a PP2-sensitive kinase, FAK or PYK2, and β1 or β3 integrin-mediated adhesion. Conclusion: The heparanase receptor(s) intimately cooperates with integrins during induction of the PI3K-AKT pathway. Significance: Key steps in the heparanase-PI3K-AKT axis were identified. Heparanase functions as a heparan sulfate-degrading enzyme and as a ligand for an unidentified signaling receptor(s). Here, several reactions involved in the activation of the PI3K-AKT pathway by latent heparanase were characterized. Protein suppression using specific siRNAs revealed that heparanase-induced phosphorylation of AKT at Ser-473 was RICTOR-mTOR-dependent, whereas ILK and PAK1/2 were dispensable. p110α was the PI3K catalytic isoform preferred by heparanase for AKT activation and cell proliferation because the p110α inhibitor YM024 blocked these processes. Heparanase-induced AKT phosphorylation was low in mouse embryonic fibroblast cells expressing a RAS interaction-defective p110α compared with wild type cells, indicating that RAS has an important role in the PI3K-AKT activation. The response to heparanase was also inefficient in suspension cultures of several cell lines, suggesting a requirement of integrins in this pathway. Adhesion via either αVβ3 or α5β1 promoted heparanase-induced AKT phosphorylation, and a stronger effect was seen when both integrins were engaged. Simultaneous inhibition of FAK and PYK2 using a chemical inhibitor, or suppression of their expression, inhibited heparanase-induced AKT activation and cell proliferation. Stimulation of cells with heparanase enhanced their resistance against oxidative stress- or growth factor starvation-induced apoptosis. These results demonstrate that there is an intimate cross-talk between the heparanase receptor(s) and integrins during induction of the prosurvival PI3K-AKT pathway by heparanase.
Factors Predicting Successful Labor Induction With Dinoprostone and Misoprostol Vaginal Inserts

OBJECTIVE: To evaluate the maternal and pregnancy characteristics that independently predict successful induction of labor, defined as vaginal delivery. METHODS: The study was a secondary analysis of the data collected during the Misoprostol Vaginal Insert Trial, a multisite, double-blind, randomized trial of women requiring cervical ripening before induction of labor. The primary outcome was to estimate the maternal and pregnancy characteristics that independently predict successful induction of labor. Univariable and multiple regression analyses were performed for maternal and pregnancy-related factors that potentially could predict a successful induction of labor. RESULTS: A total of 1,274 patients had sufficient labor and delivery data for a comparative analysis. Nine hundred sixteen (72%) induced patients subsequently had vaginal deliveries. Multiparity (odds ratio [OR] 4.63, 95% confidence interval [CI] 3.39–6.32, P<.001), maternal body mass index (BMI) less than 30 (OR 1.69, 95% CI 1.32–2.22, P<.001) and height greater than 5'5” (OR 1.47, 95% CI 1.15–1.9, P=.002), baseline modified Bishop score of 4 (OR 2.15, 95% CI 1.12–4.20, P=.047), and birth weight below 4,000 g (OR 2.17, 95% CI 1.51–3.13, P<.001) were significant for predicting successful induction of labor. Logistic regression analysis was performed to evaluate each factor as an independent predictor. In addition to the above-mentioned factors, maternal age younger than 35 years (OR 1.81, 95% CI 1.15–2.86, P=.01) and Hispanic race (OR 1.45, 95% CI 1.02–2.05, P=.036) each proved to significantly favor a successful induction. Conversely, African-American race was correlated with a higher incidence of cesarean delivery (OR 1.47, 95% CI 1.02–2.13, P<.001). CONCLUSION: Maternal characteristics such as BMI, parity, age, and race and neonatal birth weight are important variables to consider when predicting a successful induction of labor. The nearly 30% rate of cesarean delivery in this study underscores the importance of selecting appropriate candidates. LEVEL OF EVIDENCE: II
A new particle swarm optimization based auto-tuning of PID controller

Particle swarm optimization based auto-tuning of Proportional-Integral-Derivative (PID) controller is discussed in this paper. Relay feedback experiment is applied to identify the approximate parameters of PID controller first, although the parameters identified is not very accurate. Next we utilize particle swarm optimization algorithm to refining parameters of PID controller. The basic particle swarm optimization based auto tuning PID algorithm often fall into local optimum. To improve the performance of controller, an improved PSO method is proposed in this paper by dividing the searching process into two steps. First the parameter kd of particles is limited in a small space then enlarged to a larger one. Our experiments confirm the method can improve the perform ance of PID controller dramatically.
The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy.

BACKGROUND It is well established that tumors are dependent on angiogenesis for their growth and survival. Although uterine fibroids are known to be benign tumors with reduced vascularization, recent work demonstrates that the vasculature of fibroids is grossly and microscopically abnormal. Accumulating evidence suggests that angiogenic growth factor dysregulation may be implicated in these vascular and other features of fibroid pathophysiology. METHODS Literature searches were performed in PubMed and Google Scholar for articles with content related to angiogenic growth factors and myometrium/leiomyoma. The findings are hereby reviewed and discussed. RESULTS Multiple growth factors involved in angiogenesis are differentially expressed in leiomyoma compared with myometrium. These include epidermal growth factor (EGF), heparin-binding-EGF, vascular endothelial growth factor, basic fibroblast growth factor, platelet-derived growth factor, transforming growth factor-β and adrenomedullin. An important paradox is that although leiomyoma tissues are hypoxic, leiomyoma feature down-regulation of key molecular regulators of the hypoxia response. Furthermore, the hypoxic milieu of leiomyoma may contribute to fibroid development and growth. Notably, common treatments for fibroids such as GnRH agonists and uterine artery embolization (UAE) are shown to work at least partly via anti-angiogenic mechanisms. CONCLUSIONS Angiogenic growth factors play an important role in mechanisms of fibroid pathophysiology, including abnormal vasculature and fibroid growth and survival. Moreover, the fibroid's abnormal vasculature together with its aberrant hypoxic and angiogenic response may make it especially vulnerable to disruption of its vascular supply, a feature which could be exploited for treatment. Further experimental studies are required in order to gain a better understanding of the growth factors that are involved in normal and pathological myometrial angiogenesis, and to assess the potential of anti-angiogenic treatment strategies for uterine fibroids.
The Golden Rule: Exegetical and Theological Perplexities

The problem which I offer for your discussion may be raised in the following terms: if one assumes that the Golden Rule constitutes the basic moral rule about which the wisest may agree, what happens to this rule when it is put within a religious perspective, more precisely, within the perspective delineated by the symbolic network characteristic of the Jewish-Christian scriptures?
Usefulness or uselessness of GlucoWatch in monitoring hypoglycemia in children and adolescents.

To the Editor. — The article of Chase et al1 was the first report of the routine use of the GlucoWatch biographer in children with diabetes mellitus. Since May 2002 in our pediatric department, 14 children and adolescents (7–17.8 years old) and 8 young adults (18–23 years old) with type 1 diabetes mellitus wore the biographer each one on an average of 12 different occasions for a mean period of 30 days. We agree with Chase et al1,2 about the good correlation between noninvasive readings of glucose levels by GlucoWatch and finger-stick glycemia. Our patients too showed a good compliance with extemporaneous changes of therapy, diet, and physical activity in response to alarms for hypo- or hyperglycemia confirmed by finger-stick determinations (“behavioral therapy”). But in our opinion the usefulness of this device for investigating the incidence of unrecognized hypoglycemias is not absolute. In our patients, during the night, the GlucoWatch biographer recorded 7 episodes of hypoglycemia (blood glucose from 30 to 70 mg/dL) lasting from 20 to 280 minutes and confirmed by monitoring blood glucose in 4 of the 6 verified cases (85%). However, the alarm failed to alert the patient in the majority of cases, probably because the reduced awareness consequent to hypoglycemia itself. In particular, …
Esferocitosis hereditaria: de la biogénesis a la patogénesis.

La esferocitosis hereditaria es la anemia hemolitica congenita mas frecuente en la poblacion caucasica. Tiene una amplia variabilidad clinica y desde el punto de vista hematologico se caracteriza por anemia y presencia de esferocitos en la lamina periferica. Su base fisiopatologica esta determinada por el defecto de algunas de las proteinas que conforman la membrana eritrocitaria, por el efecto del bazo sobre los hematies anomalos y otros factores. A la luz de los conocimientos actuales, la interpretacion dinamica del proceso requiere adentrarse en los estadios iniciales de la hematopoyesis, pues desde etapas tan tempranas como la enucleacion del eritroblasto en la formacion del reticulocito, hasta posibles procesos inflamatorios tardios, pudieran modular la expresion de la enfermedad. Se hace una revision de las caracteristicas estructurales y funcionales de la membrana eritrocitaria y algunos aspectos generales de las propiedades del hematie para facilitar la comprension de los eventos que tienen lugar a partir del compromiso molecular de las proteinas que conforman la membrana.
A Prospective, Active-control, Non-inferiority Study of the Effectiveness of Low Molecular Weight Heparin in the Prophylaxis of Postoperative Thrombotic Events in Patients Undergoing Spinal Surgery

Background: The Incidence of verified thrombotic events after elective spine surgery is 18%. Low-Molecular- Weight-Heparin (LMWH) is routinely given on the day before surgery. A postoperative start of the thrombotic prophylaxis could be an advantage in cases with opening of the spinal canal and for preventing epidural bleeding. Patient and methods: This active-controlled non-inferiority trial compared the effectiveness and safety of LMWH started pre- or postoperatively in patients undergoing spinal surgery. We analysed the incidence of clinically symptomatic venous thromboembolism. Results: A total number of 241 patients were followed over 14.6 patient-years. The incidence risk of fatal thromboembolisms was 0.011 (95%CI 0.0003 to 0.06) for the group with preoperative treatment and 0.01 (95% CI 0.0002 to 0.04) for the postoperatively treated group. The crude risk ratio was 1.65 (95%CI 0.10 to 26.03). There was no statistically significant difference in risk across groups (p=0.72). The Poisson regression model including follow-up time showed an incidence rate ratio of 0.67 (95% 0.04 to 10.74, p=0.779). There was no increased risk for complications (p=0.211). Conclusion: This study demonstrates that the postoperative start of LMWH in the prophylaxis of thrombotic events in patients undergoing spinal surgery does not affect safety or the incidence of complications.
Mixtures of inhalation and i.v. anaesthetics at high pressure. A test of the multi-site hypothesis of general anaesthesia.

We have tested the hypothesis that anaesthetics having different pressure reversal characteristics act at different molecular sites with finite capacities and, therefore, do not necessarily have additive potencies when used in mixtures of varying composition. The additivity of the anaesthetic potencies has been tested at normal pressures and at pressures up to 100 ATA for eight combinations of the following mixtures: Althesin plus nitrous oxide; methohexitone plus nitrous oxide; thiopentone plus nitrous oxide; thiopentone plus propanidid. The anaesthetic potencies of the first two mixtures were not additive at increased pressures, whereas those of the latter two mixtures were additive. These data support the multi-site hypothesis of general anaesthesia.
Gramática del Módulo Actancial Aplicada al Estilo Periodístico (Postulados)

Los medios masivos de comunicacion ejercen un poder decisivo sobre el futuro del lenguaje y este tiene su verdadero sentido en la comunicacion. Partiendo del verbo como elemento fundamental de la predicacion, el modulo actancial abre las posibilidades de estructurar una gramatica comunicativa que fusiona el componente semantico y sintactico en el roseton predicativo, el cual permite clasificar el verbo semantica y funcionalmente, determina los principales casos en el evento y la ubicacion en el eje actancial con un planteamiento de la gramatica casual. El modulo actancial es el eje para el planteamiento de los postulados de una gramatica comunicativa aplicada al estilo periodistico.
Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals

Non-alcoholic fatty liver disease (NAFLD) incorporates an extensive spectrum of histologic liver abnormalities, varying from simple triglyceride accumulation in hepatocytes non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), and it is the most frequent chronic liver disease in the industrialized world. Beyond liver related complications such as cirrhosis and hepatocellular carcinoma, NAFLD is also an emerging risk factor for type 2 diabetes and cardiovascular disease. Currently, lifestyle intervention including strategies to reduce body weight and to increase regular physical activity represents the mainstay of NAFLD management. Total caloric intake plays a very important role in both the development and the treatment of NAFLD; however, apart from the caloric restriction alone, modifying the quality of the diet and modulating either the macro- or micronutrient composition can also markedly affect the clinical evolution of NAFLD, offering a more realistic and feasible treatment alternative. The aim of the present review is to summarize currently available evidence from randomized controlled trials on the effects of different nutrients including carbohydrates, lipids, protein and other dietary components, in isocaloric conditions, on NAFLD in people at high cardiometabolic risk. We also describe the plausible mechanisms by which different dietary components could modulate liver fat content.
A preferred music listening intervention to reduce anxiety in older adults with dementia in nursing homes.

AIM This article reports the results of a study evaluating a preferred music listening intervention for reducing anxiety in older adults with dementia in nursing homes. BACKGROUND Anxiety can have a significant negative impact on older adults' functional status, quality of life and health care resources. However, anxiety is often under-diagnosed and inappropriately treated in those with dementia. Little is known about the use of a preferred music listening intervention for managing anxiety in those with dementia. DESIGN A quasi-experimental pretest and posttest design was used. METHODS This study aimed to evaluate the effectiveness of a preferred music listening intervention on anxiety in older adults with dementia in nursing home. Twenty-nine participants in the experimental group received a 30-minute music listening intervention based on personal preferences delivered by trained nursing staff in mid-afternoon, twice a week for six weeks. Meanwhile, 23 participants in the control group only received usual standard care with no music. Anxiety was measured by Rating Anxiety in Dementia at baseline and week six. Analysis of covariance (ancova) was used to determine the effectiveness of a preferred music listening intervention on anxiety at six weeks while controlling for pretest anxiety, age and marital status. RESULTS ancova results indicated that older adults who received the preferred music listening had a significantly lower anxiety score at six weeks compared with those who received the usual standard care with no music (F = 12.15, p = 0.001). CONCLUSIONS Preferred music listening had a positive impact by reducing the level of anxiety in older adults with dementia. RELEVANCE TO CLINICAL PRACTICE Nursing staff can learn how to implement preferred music intervention to provide appropriate care tailored to the individual needs of older adults with dementia. Preferred music listening is an inexpensive and viable intervention to promote mental health of those with dementia.
Extracting Representative Information on Intra-Organizational Blogging Platforms

Content generated on intra-organizational blogging platforms may help managers understand the emerging ideas, issues, and opportunities of their companies, whereas the difficulty is how to go beyond the overload of information and obtain an overall view. This paper proposes a system framework for extracting representative information from intra-organizational blogging platforms, as well as the REPSET (REPresentative SET) method, which serves as the core component of the extraction system. Drawing from a novel clustering technique, REPSET is designed to identify a small set of items that largely represent the diversified content of a huge information base. Building on REPSET, an extraction system enables managers to locate representative articles that may serve as starting points for comprehensively understanding the hot topics, prevailing thoughts, and emerging opinions among employees. Empirical evaluations are conducted based on the massive database accumulated on an internal blogging platform at a large telecommunications company. The results from data experiments and user evaluations demonstrate that REPSET and the extraction system upon which it is based can provide outstanding performance, in comparison with benchmark methods.
Lap Cholecystectomy After Acute Gallstone Pancreatitis – Experience of Six Cases

To study the safety of cholecystectomy during the index admission following acute gall stone pancreatitis. Six patients of cholecysto-pancreatitis underwent Lap cholecystectomy during 1 year period w.e. f. oct 2015 to sept. 2016. Initial two cases underwent interval cholecystectomy (IC), while subsequent 4 cases early cholecystectomy (EC). There was no conversion or bile duct injury. Early cholecystectomy following acute gallstone pancreatitis was found to be a safe procedure when performed during index admission.
An overlap between osmotic and anaerobic stress responses: a potential role for DNA supercoiling in the coordinate regulation of gene expression

The regulation of several genes in response to osmotic and anaerobic stress has been examined. We have demonstrated a clear overlap between these two regulatory signals. Thus, the osmotically induced proU and ompC genes require anaerobic growth for optimum induction while the anaerobically induced tppB gene is also regulated by osmolarity. Furthermore, normal expression of tppB and ompC requires the positive regulatory protein OmpR, yet this requirement can be partially, or even fully, overcome by altering the growth conditions. Finally, the pleiotropic, anaerobic regulatory locus, oxrC, is also shown to affect expression of the osmoticalty regulated proU gene. The oxrC mutation is shown to affect the level of negative supercoiling of plasmid DNA and its effects on gene expression can be explained as secondary consequences of altered DNA topology. We suggest that there is a class of ‘stress‐regulated’ genes that are regulated by a common mechanism in response to different environmental signals. Furthermore, our data are consistent with the notion that this regulatory overlap is mediated by changes in DNA supercoiling in response to these environmental stresses.
Face detection using beta wavelet filter and cascade classifier entrained with Adaboost

Face detection has been one of the most studied topics in the computer vision literature due to its relevant role in applications such as video surveillance, human computer interface and face image database management. Here, we will present a face detection approach which contains two steps. The first step is training phase based on Adaboost algorithm. The second step is the detection phase. The proposed approach presents an enhancement of Viola and Jones’ algorithm by replacing Haar descriptors with Beta wavelet. The obtained results have proved an excellent performance of detection not only when a face is in front of the camera but also when it is oriented towards the right or the left. Moreover, thanks to the start period needed for the detection, our approach can be applied during a real time experience.
Characterization of the Insulin-regulated Endocytic Recycling Mechanism in 3T3-L1 Adipocytes Using a Novel Reporter Molecule*

The endocytic trafficking of the GLUT4 glucose transporter and the insulin-regulated aminopeptidase (IRAP) are regulated by insulin. We have used a chimera between the intracellular domain of IRAP and the extracellular and transmembrane domains of the transferrin receptor (vpTR) to characterize IRAP-like trafficking in 3T3-L1 adipocytes. Our data demonstrate that the cytoplasmic domain of IRAP is sufficient to target vpTR to the insulin-regulated, slow recycling pathway in adipocytes and that the dynamic retention of vpTR is dependent on a di-leucine motif. Our kinetic analysis demonstrates that vpTR recycles as a single kinetic pool and that vpTR is very efficiently sorted from endosomes to the insulin-regulated recycling pathway. An implication of these findings is that the key step in the dynamic retention of vpTR occurs within the early endosomal system. We have previously shown that vpTR is trafficked by an insulin-regulated pathway in Chinese hamster ovary cells (Johnson, A. O., Subtil, A., Petrush, R., Kobylarz, K., Keller, S., and Mc Graw, T. E. (1998) J. Biol. Chem. 273, 17968–17977). The behavior of vpTR in Chinese hamster ovary cells is similar to its behavior in 3T3-L1 adipocytes. The main difference is that insulin has a larger effect on the trafficking of vpTR in the adipocytes. We concluded that the insulin-regulated slow recycling endocytic mechanism is expressed in many different cell types and therefore is not a unique characteristic of cells that express GLUT4.
Algunos principios financieros que son consistentes con el postulado de racionalidad económica

Este trabajo de investigacion muestra la consistencia de los principios financieros mas importantes con la nocion de racionalidad economica perfecta, lo cual sugiere que la existencia de consumidores racionales es un postulado conveniente para el desarrollo adecuado de la teoria economica. Para ello la ecuacion diferencial parcial (EDP) de Black-Scholes-Merton (BSM) que determina el precio del producto derivado se obtiene bajo diferentes principios financieros tales como condiciones de no arbitraje, modelo CAPM (Capital Asset Pricing Model), portafolios replicantes, VPN (valor presente neto), modelo de Markowitz, etc. Posteriormente se obtiene exactamente la misma ecuacion de BSM utilizando un consumidor-inversionista maximizador de utilidad sujeto a su restriccion presupuestal, lo que confirma la consistencia de dichos principios financieros con la racionalidad economica.