Miracle-dz/UniFAR-FTUs huggingface dataset:
Health technology assessment of diagnostic strategies for Alzheimer’s disease

s assessed (n=819) Excluded based on criteria (n=735) 1) Not suspected of or suffering from Alzheimer’s disease or related dementias (139), 2) Different from target population (20), 3) No diagnostic intervention (394), 4) No primary data (142), 5) No economic evaluation (40). Full articles assessed (n=84) Included for review (n=9) Excluded based on criteria (n=75) 1) Not suspected of or suffering from Alzheimer’s disease or related dementias (4), 2) Different from target population (1), 3) No diagnostic intervention (31) 4) No primary data (5), 5) No economic evaluation (34) Excluded (n=354) Duplicates (84) Non-English (180) No abstract (90)
Manipulating the Tumor Microenvironment for Therapeutic Benefit

vii Chapter 1: Introduction . 1 Cancer . 1 1 The Tumor Microenvironment . 3 Carcinogenesis and the Tumor Microenvironment.4 Manipulating the Tumor Microenvironment for Therapeutic Benefit . 6 Chapter 2: Manipulating the Tumor Microenvironment for Therapeutic Benefit . 8 Introduction . 8 Targeting Hypoxia in the Tumor Microenvironment . 8 Targeting Hypoxia Response Pathways.10 Targeting the HIF1α Pathway . 10 Targeting mTOR . 12 Targeting UPR . 14 Using Hypoxia to Our Advantage.16 Use of Bioreductive Drugs.16 Manipulating Hypoxia . 18 Targeting Glucose Metabolism . 20 Targeting Glucose Transporters . 20 Targeting Hexokinase . 23 Targeting Phosphofructokinases . 25 Targeting Pyruvate Kinase M2 . 26 Targeting Pyruvate Dehydrogenase Kinase . 27 Targeting Lactate Dehydrogenase (LDH) . 28 Targeting Acidosis . 30 Targeting Proton Transport . 30 Manipulating Tumor Microenvironment pH . 33 Manipulating the Microenvironment for Therapeutic Benefit . 33 Conclusion . 35 Chapter 3: Mechanisms of Buffer Therapy Resistance . 36 Introduction . 36 Altered Tumor Metabolism.36 Tumor Acidosis and the Metastatic Cascade . 38
Debating Europe’s future

ABSTRACT The European Union – including its precursors, the European Communities – has had many ups and downs since the beginning of institutionalized integration, in the 1950s. Yet the state of the EU today seems exceptionally grave. Debates about the future of European integration are as old as the EU itself. They are particularly prevalent at times of perceived crisis. The current debate takes place at a time of undoubted crisis, even polycrisis. This article discusses the course and contours of the current debate, by looking, first, at the global context in which the debate is taking place; second, at the EU context; and, third, at the contributions to, and overall significance of, the debate so far.
Effects of Technology on Organizational Culture and Climate and Ethics: Implications for Human Service and Professional Outcomes

The study of the key empirical literature, the role of the effect of information, and communication technologies on culture and climate in organizations is a relatively recent phenomenon in administration, though there is some historical context from the empirical literature. Climate and its impact on various organizational outcomes have been investigated for less than the past 35 years. Little is available in the literature with respect to the impact of culture and climate on the role of ethics within organizations. This presentation of current studies will review and critically analyze recent quantitative research concerning ethical outcomes and the influence of organizational factors on ethical outcomes with potential relevance human service delivery organizations and to social work practice and related professions. between the “code” and “no-code” college alumni with respect to self-reported unethical behavior. However, results did reveal significant differences in self-reported unethical behavior between individuals working in organizations with a “code” of ethics and those working in organizations with “no-code”. Both the perceived embeddedness of the organizations code ethics and strength of code implementation had a significant inverse relationship on self-reported behavior. A statistical moderated hierarchical regression analysis, which controlled for social desirability bias, demonstrated that strength of code implementation had a significant main effect on self-reported behavior.
Multi-Controller Resource Management for Software-Defined Wireless Networks

Given decoupling the control layer and the infrastructure layer, the software-defined wireless networks (SDWNs) is beneficial in terms of providing both low-latency and low-energy consumption services for mobile users, where multi-controller placement and resource management become a pair of bottlenecks. In this letter, we propose an energy-aware multi-controller placement scheme as well as a latency-aware resource management model for the SDWN. Moreover, the particle swarm optimization is invoked for solving the multi-controller placement problem, and a deep reinforcement learning algorithm-aided resource allocation strategy is conceived. Finally, experimental results show that our proposed schemes are conducive to reducing both the execution time and the energy consumption of each task.
Exosomes: Biological Couriers with Transformative Messages

Exosomes are nanovesicles produced by almost all cell types to the extracellular environment. These structures, initially mistaken for “cellular dust”, are key effectors of cell-cell communication and play major roles in maintaining normal physiological function and homeostatic balance as well as relaying pathology. Given their non-immunogenicity, their native membrane composition combined with the wealth of contained bioinfomative cargoes and coupled to their innate ability to cross multiple biological barriers, these tiny sacs have merited a great deal of interest in recent years and are slowly edging their way to the surface. Accruing evidence corroborating the far-reaching potential of exosomes is ever growing and easily demonstrable. Nonetheless, progress with translation of the reported outcomes to clinical settings and recognition of these tools as a multi-application platform remains much too inadequate for the outstanding potential of these biological messengers and the entailed shift in theragnostic paradigms. The purpose of this review is to recapitulate on the most recent advances in exosome research and accentuate their momentous promise as game changers in disease diagnostics and therapeutics. Finally, market transition and commercialization efforts are highlighted with a brief commentary on the status quo.
Promoting Secure Attachment Through Parental Mindfulness and Meditation, The SAMPP Curriculum

This paper explains attachment theory, its acquisition in early childhood, and the difficulties that manifest from an insecure attachment. First time parents aspiring to raise their children differently than they were raised may lack the skills to alter habitual patterns of behaviors deeply embedded since childhood. The following research provides evidence of the myriad challenges that emerge from insecure attachments. Included are studies illustrating ways in which mindfulness and meditation have been found useful to individuals struggling with some of the challenges brought on by insecure attachments. Insecure attachments developed in early childhood have been found to impact relationships in school, work and family life. The evidence suggests that teaching mindful parenting with an attachment focus may prevent the transmission of insecure attachment to the next generation. The attached curriculum was designed to give expectant parents an opportunity to relinquish habitual, unbeneficial behaviors while helping their babies develop secure attachments by learning and practicing mindfulness and meditation skills as well as having a foundational understanding of attachment, as they begin their parenting journey.
Epidemiology of acute respiratory distress syndrome in the patients with multiple organ dysfunction syndrome in China: analyse of the 1087 MODS patients with the multi-centered, prospective method.

Objective To investigate the epidemiology of acute respiratory gastrointestinal dysfunction in the MODS patients in China.Methods Prospectively collected data of 1087 MODS patients between March 2002 and January 2005 were analysed.Patients were recruited from 37 tertiary hospitals of 11 provinces in China.Results The incidence and the mortality of ARDS in the MODS patients were 61.2% and 63.6%,repectively.The mortality within 28 days of ICU hospitalization was 57.9%. The risk factors of occurance and death included SIRS,total rating score of every organ,aging and Glasgow rating score and so on.The laborotary examinations associated with the occurance of ARDS included the amount of white blood cells of peripheral blood and the oxygen concentration of aterial blood.Conclusion MODS patients had high incidence rate of ARDS.And several risk factors influence the occurance of ARDS.MODS patients with ARDS had higher 28-day-hospitalization motality than patients without it.
Hometown advantage: the making of a modern suburb

ABSTRACT We know remarkably little about how suburbs are developed, especially in mid-sized urban centers. A wide-ranging literature review, historical and contemporary, indicates that developers are key, risk-taking agents, who seek compensation in high profit margins, and that they require local knowledge together with cooperation from local politicians with whom they develop close relations. Anecdotal evidence and plausible speculation suggest that their symbiosis is closest in suburban settings and smaller urban centers, where developers are more likely to be homegrown. A case study of the Meadowlands, a suburban project adjacent to Hamilton, Ontario, confirms these general and more geographically-specific expectations about developers and the development process. It draws on planning documents, newspaper accounts, legal decisions, and interviews with local land developers, politicians, and planners. By comparison with the United States, distinctive Canadian elements are tighter land use regulations and the supervisory role played by the province of Ontario.
Impact of the Assistive Technology Professional Involvement in the Provision of Mobility Assistive Equipment

People with disabilities who have functional mobility limitations often rely on mobility assistive equipment (MAE) to perform Mobility Related Activities of Daily Living (MRADLs). If an individual is not appropriately evaluated for Mobility Assistive Equipment to address current and prepare for future needs, negative outcomes are to be expected. The purpose of this study was to investigate differences between if an Assistive Technology Professional (ATP) was involved in the provision of MAE or if there was no ATP. The variables compared were based on demographics, current primary MAE, and baseline FMA scores. The data being analyzed was received through a pre-existing registry, with a population size of 2085 whereby 1123 met the inclusion criteria. If an ATP was involved, the individual using the MAE was more likely to have lived with their medical condition longer and use the MAE longer. The data shows that elderly females were more likely to not have an ATP, however a post hoc analysis determined that this result was more related to diagnosis than ATP involvement. Individuals who had an ATP were being provided with better quality MAE, being Group 3 power wheelchairs and ultra-lightweight manual wheelchairs compared to other wheelchairs, cane, crutches, or walkers if there was not an ATP involved. Baseline FMA scores suggest that having an ATP involved in the provision of MAE results in higher satisfaction scores than not having an ATP. Overall, this study provides evidence that an ATP has a positive impact on MAE provision by providing better quality MAE that is more durable and leads to higher self-reported satisfaction ratings.
Optimal Control for Sport Utility Vehicle System Using Linear Quadratic Integral Control Approach

The Sport Utility Vehicle (SUV) has become one of the popular vehicles to be chosen, since it was first introduced. However, the higher Centre of Gravity (C.G) and the bigger sizing at the side area have led to the stability and the handling issues that degrade the vehicle’s performances, especially during the confrontation with external disturbances. This paper presents an analysis of an optimal control that enhances the handling and stability of the SUV. The Direct Yaw Control (DYC) method was used to control the vehicle’s accuracy and robustness towards environmental parameters during the critical manoeuvre. The Linear Quadratic Regulator (LQR) and Linear Quadratic Integral (LQI) were compared to obtain the optimal performances during the control of the vehicle’s handling and stability. With the interference of an external disturbance during the critical manoeuvre, the results indicate that the LQI produce significant improvement in the vehicle’s handling and stability control.
Research on the Impacts of Servant Leadership on R&D Employee Creativity: Based on the Social Information Processing Perspective

The creativity of R&D employees is a crucial factor of enterprise competitiveness and organizational effectiveness. Leaders in organization have a big influence on R&D employee creativity. This study explores the effect of servant leadership on the creativity of R&D employees with the social information processing and regulatory focus perspective. This study takes 303 R&D staff in a domestic enterprise as research sample and collects data by questionnaire. The research finds that servant leadership is positively related to R&D employees’ promotion focus and prevention focus significantly. R&D employees’ promotion and prevention focus mediate the relationship between servant leadership and R&D employee creativity. Leader-member exchange moderates the relationship of servant leadership-R&D employees’ promotion focus and it also moderates the relationship between servant leadership and R&D employees’ prevention focus. This study can not only enrich the study of R&D employee creativity, but also has practical value to corporations.
A Model Master of Science Curriculum for Educators of Health Professionals: Instructional Alternatives, Implementation and Evaluation Plan.

The purpose of this applied research project at the College of Osteopathic Medicine of the Pacific (California) was to develop a new curriculum for the Master of Science in Education for Health Professionals program. Seven areas were explored in this study: (1) the learning needs of educators of health professionals; (2) proposed curriculum components; (3) barriers to pursuit of a graduate degree in education; (4) instructional alternatives; (5) available delivery systems to increase program accessibility; (6) an implementation plan; and (7) an evaluation plan. A review of the literature provided a foundation for the study. Methodology included telephone interviews, focus groups, reviews of course offerings and degree requirements, and use of external and internal expert information. The final product, a model curriculum for the Master of Science in Education, was developed following the validation process. Included in the appendixes are the criteria for the study and the model curriculum. (Contains approximately 150 references.) (CH) *********************************************************************** * Reproductions supplied by EDRS are the best that can be made * . : from the original document. * *********************************************************************** A MODEL MASTER OF SCIENCE CURRICULUM FOR EDUCATORS OF HEALTH PROFESSIONALS: INSTRUCTIONAL ALTERNATIVES, IMPLEMENTATION AND EVALUATION PLAN
Intelligent Tutoring: Active Monitoring and Recommendation

Society has been changing dynamically over the years and technology has been boosting that change. Teaching, as a social activity has not been changing at the same speed. Technology enhanced learning, arises as a way to cope with that challenge, opening new paths for learning. However, sometimes it becomes difficult to cope with student´s challenges: interest, motivation, attention, are difficult to achieve with the so called net-generation. With an amazing new world at the touch of their fingers, the focus is on new, challenging and interesting things, leaving very little room to other activities. Keeping students in the right track, interested and motivated is in fact an enormous challenge. Fatigue and stress play an important role in this equation: they can dramatically decrease students’ performance. Controlling these factors, in such a way that´s unaware by students, is the best way to achieve better results, as the data gathering process does not interfere with the parameters being monitored. The aim is to forecast negative situations taking some actions to mitigate them.
Family type and parents’ time with children: Longitudinal evidence for Denmark

Parental time with children is important for children’s developmental outcomes. Family type may affect the amount of time parents can and will invest in children. Using time-use panel data obtained from two waves of the Danish Time Use Survey, linked with administrative records, the study shows that parental family type had a substantial impact on the time parents spent with children. When controlling for constant unobserved individual traits, likely to affect both time-use and family type, differences in time-use increase, indicating positive selection into non-intact family types. Single parents and parents in reconstituted families spent less time on developmental activities, such as talking, reading and playing with the child, whereas parents living in reconstituted families also spent less time on non-developmental activities, such as transporting the child or performing basic childcare. Based on our findings, there are indications that cross-sectional results showing little difference in parents’ involvement in children across family types partly emanate from differential selection in family types.
Planejamento de Fármacos na Área de Doença de Chagas: Avanços e Desafios

The paper reports the general aspects about drug design and development, especially in the area of neglected diseases. The urre t s e ario is e phasized, the re e t ad a es i the Chagas’ disease he otherapy are sho a d the main challenges to be faced are discussed as well as the perspectives of the contribution of the Brazilian Medicinal Chemistry and of the Laboratory of Design and Synthesis of Chemotherapeutic Agents potentially active on Neglected
HIV/AIDS testing and counseling practices in Uganda: a program proposal

The current HIV epidemic, thought to have begun in the 1970s, was recognized as an emerging disease in the early 1980s. HIV most likely originated in the Democratic Republic of Congo around 1920 when HIV crossed the species barrier from chimpanzees to human. HIV first appeared in Uganda in 1986. Since 1992 Uganda has had a significant decline in HIV prevalence from 24 percent at the height of the epidemic to six percent in the early 2000s and remains steady. The World Health Organization program currently outlines prevention strategies: (1) testing and counseling, (2) using condoms (male or female), (3) volunteering for male medical circumcision, (4) using antiretroviral therapies (ARTs), (5) using harm reduction strategies, and (6) eliminating mother-to-child transmission. A range of factors from accessibility, availability to sociocultural norms influences the use of HIV testing and counseling services in Uganda. Currently, in Uganda, roughly half of the adult population (55 percent of women and 47 percent of men) have had an HIV test in the past year and are aware of their HIV status. The main gap in HIV testing and counseling services is the lack of community-based services. The limited community-level services and supports that exist do not cover the full continuum of care. Public Health Statement: The proposed program seeks to reduce these barriers by offering community-based HIV Testing and Counseling services at a trusted youth-focused organization, and through a community-led advocacy campaign for equitable relationships.
Lumpy Durable Consumption Demand and the Limited Ammunition of Monetary Policy

The prevailing neo‐Wicksellian view holds that the central bank's objective is to track the natural rate of interest ( r *), which itself is largely exogenous to monetary policy. We challenge this view using a fixed‐cost model of durable consumption demand, in which expansionary monetary policy prompts households to accelerate purchases of durable goods. This yields an intertemporal trade‐off in aggregate demand as encouraging households to increase durable holdings today leaves fewer households acquiring durables going forward. Interest rates must be kept low to support demand going forward, so accommodative monetary policy today reduces r * in the future. We show that this mechanism is quantitatively important in explaining the persistently low level of real interest rates and r * after the Great Recession.
Belgium Invades Germany

This chapter reviews the conceptual underpinnings of the relationships between truth and politics, how truth is both conveyed and interpreted, and how it can fall subject to distortion and misinterpretation. These patterns are presented from a historical vantage point and considered in juxtaposition to the contemporary technological age. The chapter argues that we live in a real world where people living and acting together produce facts and events that even the powerful must reckon with. It is a hard lesson to learn—that three things are simultaneously true: (1) that reality is socially constructed; and (2) that facts are hard to hold steadily in view when we approach them, as we do, through paradigms and perspectives and prior knowledge and prior ignorance and prior interpretations and prior beliefs as we all, always, inevitably do; and (3) that there are facts.
Retail internationalization: A review and directions for future research

Abstract The purpose of this article is to provide a review of scholarly articles that have examined retail internationalization issues. We identify three core areas within RI research: (1) RI drivers and impediments, (2) RI strategy, and (3) RI performance. We also discuss four RI strategy issues that have been examined: (1) RI speed, (2) Foreign market selection, (3) Foreign entry mode, and (4) Strategy employed. Based on the review, we point to multiple areas where RI research is lacking and can contribute to the advancement of the field as well as offer insightful implications for international retail managers.
Pediatric Prewriting Stroke Developmental Stages: Are Expectations Evolving beyond the Child’s Natural Capabilities?

ABSTRACT Pediatric developmental assessments from the early 1900s are different from those used more often today. Certain present-day pediatric expectations of fine motor skills, specifically those of pre-writing strokes, appear more advanced when compared to those of the past. In the mid-20th century, child developmentalists described the sequences in which children learn, but observed that skill regression occurred as children grew older and academic expectations changed. The educational theories of today neglect to examine early learning progression through the foundations of fine motor performance. Comparisons of contemporary prewriting stroke developmental sequencing within the early Gesell Developmental Schedules reveal various factors to consider when assessing children’s’ school readiness and academic access and choosing the appropriate protocol for assessment purposes. A comparison of prewriting stroke expectations gives way to the idea that today’s educational instruction expects students to do more than the developmental norms. Investigating the advances of different developmental protocols throughout the decades brings question to how prewriting stroke norms are developed and whether they need to be updated based on how expectations are determined.