Miracle-dz/UniFAR-FTUs huggingface dataset:
SLK BOMATERALS AND METHODS OF USE THEREOF

1989,005 A 1/1935 Fink et al. 4,233,212 A 11, 1980 Otoi et al. 5,047,507 A 9/1991 Buchegger et al. 5,290,494 A 3, 1994 Coombes et al. 5,606,019 A 2/1997 Cappello 5,770,193 A 6, 1998 Vacanti et al. 6,110,590 A 8, 2000 Zarkoob et al. 6,175,053 B1 1/2001 Tsubouchi 6,592,623 B1 7/2003 Bowlin et al. 6,815,427 B2 11/2004 Tsubouchi 6,902,932 B2 * 6/2005 Altman et al. . 435/395 7.057,023 B2 6, 2006 Islam et al. 7.285,637 B2 10/2007 Armato et al. 7,635,755 B2 12/2009 Kaplan 7,662.409 B2 * 2/2010 Masters . 424/484 7,674,882 B2 * 3/2010 Kaplanet al. . 530.353 7.727,575 B2 6/2010 Kaplan 7,842,780 B2 11/2010 Kaplan 2002/0028243 A1 3, 2002 Masters 2004.0005363 A1 1/2004 Tsukada et al. 2004/0266992 Al 12/2004 Migliaresi et al. 2007/0212730 A1 9/2007 Veparietal. 2008.OO85272 A1 4/2008 Kaplanet al. 2008/0293919 A1 1 1/2008 Huang et al. 2009/0202614 A1 8/2009 Kaplanet al. 2009, 0232963 A1 9/2009 Murphy et al. 2009, 0234026 A1 9/2009 Kaplanet al. 2010, 0028451 A1 2/2010 Kaplan 2010, 0046902 A1 2/2010 Georgakoudi et al. 2010/0055438 A1* 3/2010 Kaplanet al. . 428,221 2010 OO63404 A1 3/2010 Georgakoudi et al. 2010 OO65784 A1 3/2010 Georgakoudi et al. 2010.006874. 0 A1 3/2010 Perry et al. 2010, 0070068 A1 3/2010 Georgakoudi et al. 2010, 0096.763 A1 4/2010 Georgakoudi et al. 2010, 012011.6 A1 5/2010 Kaplan 2010/0178304 A1 7/2010 Kaplanet al. 2010, 0191328 A1 7/2010 Marchant et al. 2010, 0196447 A1 8/2010 Kaplanet al.
CEOR_A_203482 551..565

Gabriel Tremblay Tracy Westley Joseph C Cappelleri Bhakti Arondekar Geoffrey Chan Timothy J Bell Andrew Briggs 1Purple Squirrel Economics, New York, NY, USA; 2Pfizer Inc, New York, NY, USA; 3William R Lindsay Chair of Health Economics, Health Economics and Technology Assessment, Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK Background: Until recently, treatments for older patients with AML ineligible to receive intensive chemotherapies were limited to hypomethylating agents, low-dose cytarabine (LDAC), or clinical trials. In 2018, the FDA approved combination glasdegib (GLAS) plus LDAC based on Phase II results demonstrating improved overall survival (OS) versus LDAC alone in previously untreated AML. However, no randomized clinical trials have directly compared GLAS + LDAC with other AML treatments. Objective: Using both indirect treatment comparison (ITC) and simulated treatment comparison (STC), which adjusts for baseline differences between trials, the comparative effectiveness of GLAS + LDAC was compared with hypomethylating agent azacitidine (AZA) or decitabine (DEC). Methods: A systematic literature review identified published trials of AZA or DEC versus LDAC among older AML patients ineligible for high-intensity chemotherapy. In addition to standard and covariate-adjusted ITC, STC was performed following guidance from the NICE Decision Support Unit (DSU). Using individual patient data from the Phase II GLAS + LDAC study, population-specific OS hazard ratios (HR) for GLAS + LDAC versus AZA or DEC were compared. Furthermore, covariate-adjusted ITC (Cox multivariate models) and STC were repeated using GLAS + LDAC versus LDAC data propensity-weighted for within-trial mean cytogenetic risk. As this initial step was not specified in the DSU, results from this second method were compared to the first STC following DSU guidance only. Results: Standard ITC and STC both demonstrated significantly improved OS for GLAS + LDAC versus either AZA or DEC. Adjusting for key covariates, STC stepwise exponential models demonstrated GLAS + LDAC superiority to both AZA (HR=0.424; 95% CI: 0.228, 0.789) and DEC (HR=0.505; 95% CI: 0.269, 0.949). These significant results held using full or step-wise approaches, following DSU guidance only or the weighted STC approach. Conclusion: Using ITC and STC, GLAS + LDAC demonstrated superior OS to AZA or DEC in an adult population with previously untreated AML for whom intensive chemotherapy is not an option.
Mapping Chestnut Stands Using Bi-Temporal VHR Data

This study analyzes the potential of very high resolution (VHR) remote sensing images and extended morphological profiles for mapping Chestnut stands on Tenerife Island (Canary Islands, Spain). Regarding their relevance for ecosystem services in the region (cultural and provisioning services) the public sector demand up-to-date information on chestnut and a simple straight-forward approach is presented in this study. We used two VHR WorldView images (March and May 2015) to cover different phenological phases. Moreover, we included spatial information in the classification process by extended morphological profiles (EMPs). Random forest is used for the classification process and we analyzed the impact of the bi-temporal information as well as of the spatial information on the classification accuracies. The detailed accuracy assessment clearly reveals the benefit of bi-temporal VHR WorldView images and spatial information, derived by EMPs, in terms of the mapping accuracy. The bi-temporal classification outperforms or at least performs equally well when compared to the classification accuracies achieved by the mono-temporal data. The inclusion of spatial information by EMPs further increases the classification accuracy by 5% and reduces the quantity and allocation disagreements on the final map. Overall the new proposed classification strategy proves useful for mapping chestnut stands in a heterogeneous and complex landscape, such as the municipality of La Orotava, Tenerife.
F 6-4 意味の埋め込み表現を用いた文脈の再学習 Relearning Contexts with Sense Embeddings 小中 史人

インターネット上には膨大な数の文書が存在している. 今 日では Twitterや Facebook, Instagramなどのソー シャルネットワークサービス(Social Network Service,SNS) の普及・流行により,あらゆる人々が容易に情報を発信できる. また,過去の書籍の電子化も進んでおり,インターネット上に 存在する文書数は日々増加し続けている. これらの文書に含ま れる情報の全てを人手で把握することはできないため,計算機 技術の発展に伴い,計算機による支援が求められている. 計算機支援の 1つとして,文書検索がある. 文書検索とは,大 量の文書集合からクエリに類似する文書を抽出するタスクであ る. このタスクでは,文書の情報表現として主にBag-Of-Words を用いる. Bag-Of-Wordsはベクトルの各次元を語として考え, 各次元の成分を文書内でのその語の出現回数や重みとする. こ のため,Bag-Of-Wordsで表現された文書はスパースかつ高次 元という特徴を持つ. この方法は非常に容易に構築可能という 利点を持つ一方で,(1)短い文書に有効でない,(2)出現順序情 報の損失, (3)同義語や類義語などの単語同士の意味関係を反 映できない,という欠点を持つ. Bag-Of-Words では SNS 上で生成されるような短い文書を 扱えないため,計算機上で文の意味を表現する研究が盛んに行 われている [1] [2] [3] [4] [5] [24]. 文の意味を適切に解釈するため に,語の並びに注目した手法も提案されている [23]. 語同士の意味関係を扱うためには,外部知識の利用やコーパス を用いた表現の自動獲得が考えられる. 前者は,WordNet [16] のような人手によって構築された機械可読な辞書を用いて意 味情報を取得する. この方法は非常に細かい粒度で意味を扱
THE EFFECT OF ATTENDING DIFFERENT TIERS OF UNIVERSITIES ON FIRST JOB WAGES IN CHINA

Using data from Chinese Education Panel Survey (CEPS), we try to measure the education return of students that attended different tiers of Chinese universities with estimates of Ordinary Least Squares (OLS) and Regression Discontinuity Design (RD). For the entire sample OLS estimation indicates there are some but not enough evidence to support wage premium for fresh graduates from upper-tier universities, and the RD estimation for students with enrollment scores close to admission cut-off line does not have positive effect to their earnings after attending upper-tier universities (211 and 985 project universities). Field of Research: Regression Discontinuity, Return to education, First job wage
The Role of Reputation For Achieving Competitive Advantage

Corporate reputation is an assessment of stakeholders based on their existence, leadership, and innovation. This study empirically investigates the effects of corporate social responsibility (CSR), dynamic capabilities, reputation, and competitive advantage in manufacturing industries. An active role of manufacturing industries for involvement in CSR is needed by stakeholders in order to sustain the economic, social, and environmental aspects that ultimately increase the reputation of an objective that can be achieved by manufacturing industries. The development of dynamic capabilities is an internal factor for manufacturing industries into sections to win a competitive advantage. The authors conducted a survey to test the hypotheses and designed a SEM to analyze them. The results show that CSR has a positive effect on reputation. Dynamic capabilities have an effect on competitive advantage. This study concludes that reputation has an effect on competitive advantage. This finding integrates insights in a reputation framework into a generalization having a direct effect on competitive advantage in manufacturing industries. This research is expected to provide manufacturing industries with valuable suggestions for management practices to increase reputation and achieve the industrial goals especially to win the competitive advantage.
Overexpression of miR-1 in human PASMCs inhibits basal and hypoxia-induced proliferation

Title: MicroRNA-1 Is Decreased by Hypoxia and Contributes to the Development of Pulmonary 1 Vascular Remodeling via Regulation of Sphingosine Kinase 1 2 Running Head Title: Role of miR-1 in Pulmonary Hypertension 3 4 Authors and Affiliations: 5 Justin R. Sysol 2, , Jiwang Chen, Sunit Singla, Shuangping Zhao, Suzy Comhair, 6 Viswanathan Natarajan , Roberto F. Machado* 7 Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy; Department of Pharmacology; Medical Scientist Training Program, University of Illinois at Chicago, Chicago, IL. Cleveland Clinic, Cleveland, OH. Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine Indiana University, Indianapolis, IN.
Achieving social protection for the elderly in Kilimanjaro region, Tanzania: a call for social institutions towards improving elderly service provision

The elderly in Tanzania face social insecurity that put them at risk of great horizon of abuse, social exclusion, serious illness and abject poverty. Although, there are several social institutions addressing the risks facing the elderly in Tanzania, still the elderly’s adverse conditions remain unabated. This paper examined Social Institutions (SIs) and their respective roles in providing social security to the elderly in terms of food, health, shelter, clothing and income services. The study adopted a cross-sectional research design where a questionnaire survey, focus group discussions and key informant interviews were the main methods of data collection. The descriptive statistical analysis was employed to explore the distribution of socioeconomic characteristics and social protection. Content analyses approach was used to analyses the qualitative data. The findings show that: the family, Department of Social Welfare (DSW), Tanzania Social Action Fund (TASAF) and religious institutions were the most active SIs providing social protection to the elderly. Elderly were unsatisfied with the SIs’social services provision as they narrowly focused on health and food. There was inadequately provision of other needy services. The study recommends to government to enhance the implementation of the social protection policies and guide service provision mechanisms among SIs. There Sis should adopt joint implementation of the social protection interventions to improve the scope of services for elderly welfares.
EAU Position Piece The Role of Cytoreductive Nephrectomy : The Current EAU Position

a Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; b Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden; c Department of Urology, University Hospitals of the KULeuven. Leuven, Belgium; d The Royal Free NHS Trust and Barts Cancer Institute, Queen Mary University of London, London, UK E U R O P E A N U R O L O G Y X X X ( 2 0 1 6 ) X X X – X X X
THE USE OF ACCOUNTING INFORMATION BY FINANCIAL ANALYSTS IN EMERGENT MARKETS: THE CASE OF ROMANIA

The purpose of this paper is to investigate the use of accounting information by Romanian financial analysts with a focus on the models used and the factors affecting their forecasts accuracy. We hypothesize that on the emergent market of Romania, analysts rely more on simple valuation models (such as price multiples) and that accounting variables are perceived as less important compared to macroeconomic factors when it comes to forecast accuracy. To collect data we sent out questionnaires to the Research Departments of the brokerage companies authorized to operate on the Bucharest Stock Exchange (BSE) (investment firms, financial investments banks, credit institutions). As IFRSs became mandatory for consolidated accounts of listed companies and as the National Securities and Exchange Committee (CNVM) envisions the application of IFRS in the individual accounts of these companies, the paper also tries to capture the perception of Romanian financial analysts on the role plaid by IFRS adoption in reducing forecasts errors.
Point-spread Function Ramifications and Deconvolution of a Signal Dependent Blur Kernel Due to Interpixel Capacitive Coupling

Interpixel capacitance (IPC) is a deterministic electronic coupling that results in a portion of the collected signal incident on one pixel of a hybridized detector array being measured in adjacent pixels. Data collected by light sensitive HgCdTe arrays which exhibit this coupling typically goes uncorrected or is corrected by treating the coupling as a fixed point-spread function. Evidence suggests that this IPC coupling is not uniform across different signal and background levels. This variation invalidates assumptions that are key in decoupling techniques such as Wiener Filtering or application of the Lucy–Richardson algorithm. Additionally, the variable IPC results in the point-spread function (PSF) depending upon a star’s signal level relative to the background level, among other parameters. With an IPC ranging from 0.68% to 1.45% over the full well depth of a sensor, as is a reasonable range for the H2RG arrays, the FWHM of the JWSTs NIRCam 405N band is degraded from 2.080 pix (0.″132) as expected from the diffraction pattern to 2.186 pix (0.″142) when the star is just breaching the sensitivity limit of the system. For example, When attempting to use a fixed PSF fitting (e.g., assuming the PSF observed from a bright star in the field) to untangle two sources with a flux ratio of 4:1 and a center to center distance of 3 pixels, flux estimation can be off by upwards of 1.5% with a separation error of 50 millipixels. To deal with this issue an iterative non-stationary method for deconvolution is here proposed, implemented, and evaluated that can account for the signal dependent nature of IPC.
Therapeutic Potential of Tumor Suppressors in Treating Breast Cancer

Despite significant advances in early detection and treatment, breast cancer remains a major cause of morbidity and mortality in women. The etiology of breast cancer involves a complex interplay of genetic, hormonal and dietary factors [1]. Recent studies have provided greater insights into the molecular mechanisms of breast carcinogenesis, which has enabled novel therapeutic strategies that target the molecular and genetic processes triggering neoplastic transformation. Genes affecting the cellular processes involved in neoplasia are classified as proto-oncogenes and tumor suppressor genes, and they regulate proteins involved in cell growth and proliferation. Therefore, mutations in these genes can contribute to the development of cancer [2]. Some oncoproteins and tumor suppressors directly regulate cell proliferation (either promoting or inhibiting), programmed cell death or apoptosis, and DNA repair [6]. Increasing knowledge of these genes and their involvement with the neoplastic pathways has provided greater opportunities to develop targeted therapeutics, which offer higher specificity, Abstract
Th 17-Associated Inflammation Promotes Papilloma Development by Up-regulating γ IFN

IFN; plays a crucial role in immunity against a variety of transplanted tumors and methylcholanthrene-mediated tumorigenesis in mice. However, it is not clear whether and how endogenous IFN; influences 7,12-dimethylbenz(a)anthracene (DMBA)–induced and 12-O-tetradecanoylphorbol-13-acetate (TPA)–induced papilloma development. We found here that IFN; expression was markedly up-regulated shortly after DMBA/TPA application to the skin. Surprisingly, neutralizing IFN; activity in vivo did not increase but rather decreased tumor development. Furthermore, IFN; receptor–deficient mice were also more resistant to papilloma development than their counterparts were. IFN; acted mainly in the promotion stage of papilloma development by enhancing TPA-induced leukocyte infiltration and epidermal hyperproliferation. The up-regulation of tumor necrosis factor A, interleukin (IL)-6, and transforming growth factor B was largely dependent on host IFN; responsiveness. Remarkably, up-regulation of both IL-17 expression in the skin and T helper 17 (Th17) cell number in draining lymph nodes after DMBA/TPA treatment was dependent on IFN; signaling. Depletion of IL-17 not only decreased the DMBA/TPA–induced inflammation and keratinocyte proliferation but also delayed papilloma development. These results show that IFN;, under certain conditions, may promote tumor development by enhancing a Th17-associated inflammatory reaction. [Cancer Res 2009;69(5):2010–7]
Index Terms— Electricity Reliability Council of Texas, Energy Management System, State Estimator, Real Time Contingency Analysis, Voltage Security Assessment Tool I. NOMENCLATURE EMS: Energy Management System ERCOT: Electric Reliability Council of Texas RTCA: Real Time Contingency Analysis RTNET: Re

State Estimator (SE) is an important tool that ERCOT relies on to monitor the real time state of power grid. SE allows the operator to monitor the power system and determine the level of reliability and security. Hence it is imperative to monitor the quality of “SE performance”. This paper will present the details of the tools that ERCOT uses to assess SE performance.
Analysis by state equation of a control strategy for hybrid filter

A control algorithm is proposed for a three-phase hybrid power filter constituted by a series active filter and a passive filter connected in parallel with the load. It is based on the dual formulation of the vectorial theory of instantaneous reactive power, so that the voltage waveform injected by the active filter is able to compensate the reactive power and the harmonics of the load current. System state model was obtained and the system behaviour was analyzed by the state equations for each situation. The analysis developed has allowed the knowledge of the system dynamic behaviour and the stability margins. An experimental prototype has been developed, and simulation and experimental results are presented.
Cognitive control in patients with alcohol use disorder: testing a three-function model

Results: A model of patients’ cognitive control dysfunction is developed using principal component analysis. It includes response inhibition and working memory components and explains 87.3% of cognitive control variance. The comparison between “low” and “high” cognitive control groups yielded significant differences in verbal and working memory (p<0.001), processing speed (p=0.006) and emotional processing (p<0.01) tasks. When compared with the normative data, the low cognitive control group exhibited deficits in working memory, motor skills, processing speed, planning and decision-making, and emotional processing (all at the p<0.001 level). No other significant differences were observed.
Measurement of technical efficiency that involving farmers preferences towards risk of rice farming in Malang (Indonesia)

The aim of this research is to analyse the level of technical efficiency of rice farming by considering farmer preferences towards natural and technological risks. This research is conducted in selected regions in Malang Regency (Indonesia) with the consideration that farmers in selected areas can produce high productivity, but productivity growth fluctuates very sharply each year (within 13 years). Natural phenomenon that often appears as the risks of farming, such as, floods, droughts, and hurricanes. While, the application of technology is the part of the risks of farming, too, because farmers are not willing to adopt the technology which facilitated by the government. Rice farmers who used respondents are 305 people namely spread in seven selected regions in two seasons. The method used are a) Expected Utility of Money to measure the farmer preferences towards the risks and b) Stochastic Frontier Translog production function with Maximum Likelihood Estimation (MLE) approach to analyse the level of technical efficiency of farming. The results found that 77.7% of farmers have averter risk preferences, the level of technical efficiency obtained at 0.75 by pooling the data, and the influence of the preference of farmers to sources of technical inefficiency is -0622. Recommendation submitted is induced the technology with mentoring system and immediately implement the agricultural insurance.
High Convergence Rates of Digital Image Transformat ion by Numerical Integration Using Spline Functions

This paper introduces aa intriguing topic in image processing where accuracy of images even in details is important and adopts an intriguing methodology dealing with discrete topics by continuous mathematics and numerical approximation. The key idea is that a pixel of images at different levels can be quantified by a greyness value, which can then be regarded as the mean of an integral of continuous functions over a certain region, and evaluated by numerical integration approximately. However, contrasted to the traditional integration, the integrand has different smooth nature in different subregions due to piecewise interpolation and approximation. New treatments of approximate integration and new discrete algorithms of images have been developed. The cycle conversion T-‘T of image transformations is said if an image is distorted by a transformation T and then restored back to itself by the inverse transformation T-‘. Combined algorithms of discrete techniques proposed in [l-3] only have the convergence rates 0(1/N) and 0(l/N2) of sequential greyness errors, where N is the division number for a pixel split into N2 subpixels. This paper reports new combination algorithms using spline functions to achieve the high convergence rates 0( 1/N3) and 0( l/N*) of digital image transformations under the cycle conversion. Both error analysis and numerical experiments have been provided to verify the high convergence rates. High convergence rates of discrete algorithms are important in saving CPU time, particularly to multigreyness images. Moreover, the computational figures for real images of 256 x 256 with 256 greyness levels, in which N = 2 is good enough for practical requirements, display validity, and effectiveness of the new algorithms in this paper. @ 2001 Elsevier Science Ltd. All rights reserved. Keywords-Numerical integration, Spline function, Convergence rates, Image transformation, Splitting-integration method, Image processing, Computer version, Pattern recognition.