Miracle-dz/UniFAR-FTUs huggingface dataset:
Rapid Progression of Parkinsonian Symptoms in Lewy-Body Dementia after Administration of Antipsychotics: Case Report

This is a case of a 60y/o Female, domiciled in an apartment, unemployed, no prior psychiatric history, brought in by EMS activated by daughter because patient was increasingly withdrawn, getting more and more agitated , paranoid and not maintains her ADL. On questioning, patient mentions that she feels tired, did not sleep for many days and does not want to give enough information but reported that, “lady upstairs in my apartment is against me, does not like me, playing loud music in the middle of the night and disturbed me, and I can’t sleep. ” As per daughter, patient was living alone in an apartment, doing everything on her own, but since the past few months patient is gradually becoming more and more isolated and withdrawn, not taking care of herself. As per daughter, her mother was always active, cooked on her own; always cleaned the apartment, good hygiene, always did her nail , but since the past few months patient is not cooking, the apartment is a mess, not clean at all, they found no food in the refrigerator, and losing weight. As per other family members, the patient is also increasingly paranoid, irritable and thinks that lady upstairs is against her and disturbs her by playing loud music. Patient’s daughter spoke with the lady upstairs on her mom’s persistence, who told the patient’s daughter that she is not playing any loud music and in fact goes to work and sleeps early. Patient additionally has been threatening people including her daughter lately. As per daughter; patient has become more forgetful, with perseveration. According to her daughter, patient had past history of IV heroin abuse (20 years ago) and alcohol abuse, Abstract
Nitrogen use efficiency of Quercus serrata seedlings under different soil nitrogen and phosphorus supplies

Nitrogen use efficiency (NUE), defined as the ratio of biomass growth and the nitrogen (N) taken up from a soil, is widely used in the evaluation of plant N economy. We conducted a fertilization experiment with Quercus serrata seedlings under different soil N and phosphorus (P) levels to determine the influence of high N deposition levels under different P availabilities upon NUE, plus the NUE components N productivity (NP), and mean residence time of N (MRT). The seedlings were grown for one growing season in the potted soil under three N levels (0, 50, and 100 kg N ha) combined with two P levels (0 and 50 kg P ha). Nitrogen supply to the soil reduced NUE by decreasing NP and MRT, whereas P supply enhanced NUE. Although P supply did not have a significant influence on the reduction of NUE with increasing N levels, it affected the response of the NUE components with increasing N levels. Within leaves, N supply reduced the photosynthetic nitrogen use efficiency (PNUE), P alleviated this reduction. Therefore, P is considered as one of the key factors determining the change of NUE in Q. serrata under the influence of high N supply.
Gatekeeper helix activates Golgi SM protein Sly1 and directly mediates close-range vesicle tethering

The essential Golgi protein Sly1 is a member of the SM (Sec1/mammalian Unc-18) family of SNARE chaperones. Sly1 was originally identified through gain-of-function alleles that bypass requirements for diverse vesicle tethering factors. Employing genetic analyses and chemically defined reconstitutions of ER-Golgi fusion, we discovered that a loop conserved among Sly1 family members is not only autoinhibitory, but also acts as a positive effector. An amphipathic helix within the loop directly binds high-curvature membranes; membrane binding is required for relief of Sly1 autoinhibition and allows Sly1 to directly tether incoming vesicles to the Qa-SNARE on the target organelle. The SLY1-20 allele bypasses requirements for diverse tethering factors but loses this functionality if Sly1 membrane binding is impaired. We propose that long-range tethers, including Golgins and multisubunit tethering complexes, hand off vesicles to Sly1, which then tethers at close range to activate SNARE assembly and fusion in the early secretory pathway.
The road to develop prisoners’ skills and attitudes: an analytical study of contemporary prison-based rehabilitation programme in Sri Lanka

The place of rehabilitation programmes in the reformation and transformation of prison inmates has continued to be on the front burner of professionals such as educators, counsellors, social workers, psychologists and medical doctors. Analysis has taken something of a top-down approach, and consideration has been placed on how the organizational context of individual prisoners interact with those rehabilitation programmes has been neglected. Drawing on interview data, this study aims to add to our understanding how rehabilitation programme affects inmates’ skills and attitudes in Sri Lankan prisons. ,This study used an inductive qualitative case study approach as it requires a deep understanding of the effect of rehabilitation programme on inmates’ skills and attitudes and how inmates view rehabilitation programmes. ,The study identified seven views of inmates regarding rehabilitation programmes conducted and understood that rehabilitation programme facilitates inmates to acquire strong self-assurance of future career options and deal with potentially destructive feeling such as anger, frustration and loneliness. However, inmates who showed a strong propensity to suffer injustice and internalized blame have found no substantial impact on their skills and attitude through the programme. ,It is arguable that operation of meaningful prison-based rehabilitation programme is influenced by comprehensive picture of the profile of the prison population, shortages in resources, the attitudes of prison staffs, inability to meet real world settings and network building with a wide range of private, public or voluntary providers. ,This study represents the first prison-based study to understand the inmates view on the rehabilitation programmes in Sri Lanka.
Dixie’s Drivers: Core Values and the Southern Republican Realignment

Scholarly accounts attribute the American South’s historic partisan transformation that began in the 1960s to a combination of political and economic factors, but no prior work emphasizes the connection between individuals’ fundamental beliefs and partisan change. Using pooled American National Election Studies (ANES) data from 1988 to 2016, we show that egalitarianism and moral traditionalism are more likely to influence southerners’ party affiliation relative to non-southerners. Southerners did not connect their core values to the same extent as other citizens in the early years of our analysis—owing to the vestiges of a one-party system operating in Dixie. But over time, the relationship between core values and partisanship among southerners strengthened remarkably. Moreover, 1992–96 panel data show that egalitarianism in particular influences southern partisanship (but not vice versa). Our results reveal that core values are integral to understanding the southern Republican realignment and southerners’ persistent political distinctiveness.
Low Volume Resistance Exercise Prevents Loss of Muscle Mass and Function During 14 Days of Knee Immobilization

We aimed to determine the effectiveness of a low volume of high-intensity resistance exercise, alone (EX) or in combination with a whey protein supplement (WHY +EX), on prevention of muscle mass and strength loss following 14 days ofknee immobilization in humans. Seventeen recreationally active (i.e., exercise :S 2-3 d·wk-) participants (23.9±5.0 yr; BMI = 25.4±3.6 kg·m-) were divided into three groups: exercise (EX; n=6), whey protein supplementation with exercise (WHY +EX; n=6), and control (CON; n=5). All subjects wore a knee-immobilization brace such that one leg was completely non-weight bearing for 14d. The resistance exercise (RE) were performed unilaterally and consisted of one set often repetitions of leg press (with plantar flexion at full extension), knee extension, and seated calf raises every other day during the 14d immobilization period, at 80% of one repetition maximum. Subjects in the WHY +EX group consumed two 30g boluses of whey protein daily while EX and CON consumed isocaloric carbohydrate beverages. Immobilization induced a significant reduction (p<0.05) in thigh cross-sectional area (CSA), isometric knee extensor strength, and isometric plantar flexion strength in CON but not in EX and WHY +EX. There were significant losses in lower leg CSA for all three groups, with a tendency for losses to be mitigated in both the EX and WHY +EX groups versus CON (p=0.065). The two constituent muscles of the triceps surae muscle group showed a differential response to theRE training with the gastrocnemius showing reductions in CSA almost uniformly across the three groups whereas soleus CSA was significantly reduced in the CON (p<0.05) but not in the EX and WHY+EX groups. We conclude that a relatively low
Authors’ reply: role of natriuretic peptide receptor C signalling in obesity-induced heart failure with preserved ejection fraction with pulmonary hypertension

We thank Eroume-A Egom and Kamgang for their interest in our article and the opportunity to further discuss our work, particularly in the context of existing literature on the role of the natriuretic peptide clearance receptor (NPRC) in pulmonary hypertension and heart failure with preserved ejection fraction (PH-HFpEF). Growing evidence suggests that lower circulating levels of natriuretic peptides (NPs) in PH-HFpEF and decreased downstream cGMP/PKG signaling are important pathogenic mechanisms. Since circulating NPs can be decreased either by neprilysin-mediated degradation or NPRC-based clearance, and recently studies have shown a neutral effect of neprilysin inhibition upon outcomes in PH-HFpEF, it is plausible that increased expression of NPRC may play an important role in promoting PH-HFpEF as it does in promoting known comorbid conditions such as obesity and metabolic syndrome. In general, progress in identifying therapies for PH-HFpEF has been hampered by the lack of pre-clinical models that faithfully recapitulate human manifestations of PH-HFpEF, including models that utilize Ang2 stimulation. Unfortunately, human studies investigating ACE inhibition and ARB therapies have not proven effective in HFpEF, calling into question the relevance of this model to HFpEF pathobiology. Alternatively, there is a growing acceptance that obesity and metabolic syndrome may play a pathogenic role in the development of PH-HFpEF in a subset of patients. Thus, while no single model is likely to perfectly recapitulate the heterogeneous syndrome of PH-HFpEF, we believe that our model of obesity-induced PH-HFpEF is highly relevant to this important subpopulation of PH-HFpEF and shares similar findings of disproportionate RV remodeling. We read with interest the potential role that the NPRC may play in the development of PH and sinoatrial disease. While the findings are certainly intriguing and further investigation of NPRC’s role in PH-HFpEF is warranted, we respectfully disagree with the overall conclusion that NPRC must be regarded as a protective receptor in the heart. Rather, there is an alternative explanation for the previously cited findings. NPRC is well known to play an important role in modulating blood pressure, and the lack of development of systemic hypertension may have been a confounding explanation for why a ‘‘protective’’ effect of NPRC was observed in previous studies. In the studies directly investigating PH-HFpEF phenotypes in NPRC / mice or with administration of NPRC agonist, ANP-4-23, the authors
Sampling and extraction methods for soil inorganic N determination to calibrate the EM38 in irrigated fields

xi CHAPTER 1. MOTIVATION, OBJECTIVES AND LAYOUT . 1 1.1 Motivation and objectives . 1 1.2 Organization of the dissertation . 3 CHAPTER 2. LITERATURE REVIEW . 4 2.
Reperfusion Therapy of Myocardial Infarction: From Classic to Modern Fibrinolysis

Streptokinase, the historically (and currently) most used fibrinolytic drug is far from ideal: in addition to a low reperfusion rate (TIMI 3 flow around 60%), it must be used by intravenous infusion and it has other problems as immunogenicity (which conditions allergies and antibodies) or hypotension, a big issue in patients with severe heart failure or cardiogenic shock. Besides, the success of fibrinolysis (as occurs in stroke) is very time-dependent, being clearly more effective within 1st hour of myocardial infarction. Culprit artery re-occlusion is an additional problem. New (and more expensive) fibrin specific drugs, such as tpA (alteplase), rpA (reteplase) and TNK-tpA (tenecteplase), tried to overcome these problems. In fact TNK, the most modern of them, has several advantages: is fibrin-specific, used by intravenous bolus and it does not induce hypotension or immunogenicity.
PHALERIA MACROCARPA LEAF EXTRACT-CHITOSAN NANOPARTICLES SUPRESS ANGIOGENESIS INDUCED BY DEXTRAN SODIUM SULFATE IN MICE COLON

Objective: Although an anti-inflammatory effect of Phaleria macrocarpa (Mahkota Dewa in Indonesian) leaf extract has been reported, the extract shows toxicity as the dose increases. Chitosan nanoparticles are known to have transport properties that can enhance the targeting of active compounds to tissues at a lower dose. The present study sought to determine whether the extract in chitosan nanoparticles can suppress angiogenesis in the colon tissue of mice. Methods: We determined the antiangiogenic effect in 6 groups Swiss Webster mice: normal (N) group, negative control (NC) administered drinking water containing DSS 2% w/v (7 d) and followed by water without DSS (7 d) in 3 cycles, 12.5 and 25 mg leaf extract of P. macrocarpa/mouse (EPM 12.5 and EPM 25) groups, and 6.25 and 12.5 mg leaf extract of P. macrocarpa in chitosan nanoparticles/mouse (NPPM 6.25 and NPPM 12.5) groups. Hematoxylin and eosin-stained samples was performed to determine the amount of angiogenesis in the colon tissue. Results: The angiogenesis in the NPPM 12.5 (p = 0.105) and EPM 25 (p = 0.07) groups was not significantly different to that in the negative control group (administered DSS alone). By contrast, angiogenesis in the EPM 12.5 (p = 0.03) and NPPM 6.25 (p = 0.02) groups was significantly less than that in the DSS group. Conclusion: Angiogenesis in the colon tissue of mice was reduced by the extract with or without chitosan nanoparticles. The greatest reduction was found for the 12.5 mg/mouse dose of P. macrocarpa leaf extract in chitosan nanoparticles.
Effects of 5 MeV Proton Irradiation on 1200 V 4H-SiC VDMOSFETs ON-State Characteristics

The effects of 5 MeV proton irradiation on ON-state characteristics of 1200 V 4H-SiC VDMOSFETs are investigated in this paper, and related mechanisms have been revealed by the analysis of their test structure of ohmic contacts, lateral nMOSFETs and MOS capacitors simultaneously fabricated on same wafer. The results show that the threshold voltage (<inline-formula> <tex-math notation="LaTeX">$\text{V}_{\mathrm {TH}}$ </tex-math></inline-formula>) decreases obviously with increasing irradiation doses because the dominant hole traps induced by nitrogen passivation might capture more holes produced by the ionization effect of proton irradiation, resulting in the generation of net positive charges nearby the SiO<sub>2</sub>/4H-SiC interface. The interface trap density (Dit) extracted by subthreshold swing increases but field effective mobility (<inline-formula> <tex-math notation="LaTeX">$\mu _{\mathrm {FE}}$ </tex-math></inline-formula>) is improved with increasing irradiation doses. The un-trapped near interface electron traps (NIETs) are reduced by the ionization effect of proton irradiation, which could be beneficial to the improvement of <inline-formula> <tex-math notation="LaTeX">$\mu _{\mathrm {FE}}$ </tex-math></inline-formula>. And after the maximum irradiation dose of <inline-formula> <tex-math notation="LaTeX">$1\times 10^{14}$ </tex-math></inline-formula> p/cm<sup>2</sup> the VDMOSFET fails in the ON-state capability. Before it fails, the ON-state resistivity (<inline-formula> <tex-math notation="LaTeX">$\text{R}_{\mathrm {ON}}$ </tex-math></inline-formula>) firstly decreases and then increases with the increase of irradiation dose. The deterioration of the resistance of lightly doped drift region (<inline-formula> <tex-math notation="LaTeX">$\text{R}_{\mathrm {D}}$ </tex-math></inline-formula>) and the resistance of JFET region (<inline-formula> <tex-math notation="LaTeX">$\text{R}_{\mathrm {JFET}}$ </tex-math></inline-formula>) caused by the displacement effect of proton irradiation covers up the improvement of the channel resistance (<inline-formula> <tex-math notation="LaTeX">$\text{R}_{\mathrm {CH}}$ </tex-math></inline-formula>) with increasing irradiation doses, finally leading to the failure of the VDMOSFET at the maximum proton irradiation dose.
MODIFICATION AND PARALLELIZATION OF GENETIC ALGORITHM FOR SYNTHESIS OF ARTIFICIAL NEURAL NETWORKS

Context. The problem of automation synthesis of artificial neural networks for further use in diagnosing, forecasting and pattern recognition is solved. The object of the study was the process of synthesis of ANN using a modified genetic algorithm. Objective. The goals of the work are the reducing the synthesis time and improve the accuracy of the resulting neural network. Method. The method of synthesis of artificial neural networks on the basis of the modified genetic algorithm which can be implementing sequentially and parallel using MIMD – and SIMD-systems is proposed. The use of a high probability of mutation can increase diversity within the population and prevent premature convergence of the method. The choice of a new best specimen, as opposed to a complete restart of the algorithm, significantly saves system resources and ensures the exit from the area of local extrema. The use of new criteria for adaptive selection of mutations, firstly, does not limit the number of hidden neurons, and, secondly, prevents the immeasurable increase in the network. The use of uniform crossover significantly increases the efficiency, as well as allows emulating other crossover operators without problems. Moreover, the use of uniform crossover increases the flexibility of the genetic algorithm. The parallel approach significantly reduces the number of iterations and significantly speedup the synthesis of artificial neural networks. Results. The software which implements the proposed method of synthesis of artificial neural networks and allows to perform the synthesis of networks in sequentially and in parallel on the cores of the CPU or GPU. Conclusions. The experiments have confirmed the efficiency of the proposed method of synthesis of artificial neural networks and allow us to recommend it for use in practice in the processing of data sets for further diagnosis, prediction or pattern recognition. Prospects for further research may consist in the introduction of the possibility of using genetic information of several parents to form a new individual and modification of synthesis methods for recurrent network architectures for big data processing.
Tunable structure and electronic properties of multilayer PtSe2

Two dimensional (2D) materials such as graphene and transition metal dichalcogenide (TMDC) like MoS2, WTe2 have brought widespread attention as their novel 2D confined properties and applications in nano devices. Among them, the up to date multilayer PtSe2 has been reported to be high mobility, air stable and possess novel phenomenon like Dirac fermions but to date have little study as the tunable electronic properties via structural control. Here we use the first principle calculations based on density functional theory (DFT) to study the tunable structure and electronic properties of monolayer and multilayer PtSe2 by the method of strain. We find that when apply compress strain on monolayer PtSe2 at -3% or more, the photoluminescence will enhance due to a larger density of states at conductance band minimum (CBM). With the increase of layer number, the band gap become small rapidly. The band gap change from 1.3 eV for monolayer to 0.4 eV for bilayer. With three layers, the band gap becomes 0.1 eV. Begin at four layer, the PtSe2 multilayer become a negative band gap semimetal. The DOS under VBM is small for multilayers due to the large splitting between the first valence band with the second valence band. This indicate the possible low photoluminescence strength for these multilayers. Our results can pave a way for the experiment electronic and optical properties tuning in multilayer PtSe2 and possible in the similar TMDCs.
Thinking styles and time perspectives

Abstract The principal objective of this research was to examine the relationships between thinking styles and time perspectives. Four hundred and fifty-one secondary school students from Hong Kong responded to the Thinking Styles Inventory-Revised II (TSI-R2) and the Zimbardo Time Perspective Inventory (ZTPI). Results showed that when gender, school year level, and age were taken into account, thinking styles significantly predicted time perspectives. Students possessing successful thinking styles (i.e. using a wide range of thinking styles, especially creativity-generating styles) tended to have the more desirable time perspectives. The optimal profile of a balanced time perspective was predicted positively by the hierarchical and external styles. Implications of the findings for secondary school students and educators are discussed.
Enabling Security-Aware D2D Spectrum Resource Sharing for Connected Autonomous Vehicles

With the emergence of automated driving technology, wireless demand for secure information exchange among automated vehicles has increased dramatically. To this end, we design a security-aware dynamic device-to-device (D2D) spectrum resource sharing mechanism to enhance the security of vehicular D2D communications with the improved spectrum efficiency. Considering both resource block (RB) sharing and power control, we model this joint D2D spectrum resource sharing process as a weighted bipartite graph matching problem whose weights are obtained through deriving the closed-form solutions of power control in an algebraic method. Then, the global optimal solutions of the matching problem are obtained by using the Hungarian algorithm. Furthermore, a security-aware RB and power allocation (SA-RBPA) mechanism compatible with existing cellular networks is proposed for the small cell base station applications. Extensive simulation results have shown that, compared with existing approaches that consider RB reusing strategy or power control scheme optimization alone, the SA-RBPA scheme is able to realize a better spectrum efficiency and security performance.