Miracle-dz/UniFAR-FTUs huggingface dataset:
Gray scale and color Doppler ultrasonography findings in the diagnosis of prostate cancer

Purpose: The aim of this study is to investigate the relationship between tumoral malignancy potentials and transrectal gray scale ultrasonographic findings in prostate cancer and to investigate the contribution of transrectal color Doppler ultrasonography to the diagnosis. Material and methods: We evaluated 63 patients with prostate cancer who underwent transrectal associated biopsy in our study. In all patients, gray scale ultrasonography, color Doppler ultrasonography findings, serum PSA levels, pathology results were compared and the relationship between them was investigated. Results: While moderately differentiated tumors were more hypoecogenic (69%), poorly differentiated tumors were observed to have mixed echogenicity (58%). All of the isoecogenic tumors were in the good or moderate differentiation group. In 11 (17%) of 65 cancer regions, no blood flow was detected in Doppler US (grade 0). Eight (12%) of 65 patients had first degree blood flow, while 46 (71%) had second degree blood flow. It was determined that the PSA values significantly increased as the degree of vascularization of the lesions increased. Significant correlations were also found between the Gleason scores of the tumors and the blood flow grade. All lesions with no evidence of color Doppler ultrasonography are found in the good or moderately differentiated cancer group. On the other hand, the majority (98%) of the cancers in which significant blood flow is detected are found in the moderate or poorly differentiated group. Conclusion: There was no additional contribution of color Doppler ultrasonography to gray scale ultrasonography in detecting prostate cancer. However, it has been observed that the gray scale ultrasonography contributes to the manifestation of suspicious lesions. Significant links between cancer blood levels and Gleason scores were noted. Accordingly, it has been observed that cancers that show significant blood flow with color Doppler ultrasonography have higher malignancy than cancers that do not have blood or minimal blood supply. Research Article Gönderilme tarihi:16.07. 2018 Kabul tarihi:09.11. 2018
Tradition meets Tech noh logy: Integrating Japanese Noh & New Technology in Shakespeare’s Macbeth

This paper addresses technical and aesthetic problems encountered in adapting Shakespeare’s Macbeth to the noh stage, used for the six hundred year-old dance-drama form. In July, 2009 the Noho Theatre Group created a dancing Witch and Ghost for Sleep no More, Lady Macbeth’s Nightmare by integrating motion-capture technology to create 3D computer graphic animations set to automatic choreography, which were then projected on a screen. Sleep no More, performed bilingually in English and Japanese, by noh and kyogen actors with modern actors and dancers, was given a public rehearsal July 17th at the Oe Noh Theatre, Kyoto. This paper examines the problems in screen placement, interaction of performers with technology, as well as performer’s reflections and audience reception.
Support Institutions and R&D Activities in an ICT Cluster

Economic geography in an era of global competition poses a paradox. In theory, location should no longer be a source of competitive advantage. Open global markets, rapid transportation and high-speed communications should allow any company to source anything from any place at any time. But in practice, location remains central to competition and institutions seem to help in the development of regions. This article examines the role of Malaysia's Multimedia Development Corporation as a regional development agency—in the development of the MSC Project—the Multimedia Super Corridor Cluster, a project to develop the information and communications technology sector, started by the government of Malaysia to kickstart the transition to a knowledge-based economy. Even though the MDC has played a significant role in developing the MSC project, there is much more it can do to develop it as a ‘regional cluster’. It is concluded that the MDC has been doing a good job of marketing the MSC in general and attracting companies to set up shop in Malaysia in order to form a new knowledge-based sector. It is suggested that the business-related function should receive equal attention when any innovation cluster is designed and operated.
Gelatin Endorses the Pluripotent Stem Cells from the Reprogrammed Fibroblasts of Adult Mice Differentiation into Subtypes of Neurons in the Feeder-Free Condition for a Long-Term

Stem cell research and application in the basic and clinical fields have been leading a prevalent in the past 20 years since these present significantly promising meanings. The relevant technologies have momentously advanced, including the cellular matrix to offer stem cells growing healthily environment. Stem cells can originate from several resources such as embryonic and induced pluripotent stem cells (iPSCs) but they all are dependent on a monolayer of feeder-cells, which are, in the original and most time, on the primary mouse embryonic fibroblasts (MEF feeder cells) to sustain their self-renewal growing. However, even though MEF application is still widely applied in the research laboratory and commercial supplies, it meets inordinate challenging since it appears some noteworthy problems such as zoonosis, contaminations, and inconsistence outcomes. Importantly, the hindmost of those halts the downstream applications of stem cells, in particular, in the clinical application. Thus, scientists have hunted around the replacements either biomaterials or non-biomaterials and their mixtures. Recently, we magnificently employed the gelatin-alone-coated dishes in feeder-free condition with the opposite medium for the proliferation of iPSCs derived from the reprogrammed fibroblasts of the adult mouse to overcome these drawbacks of MEF. Moreover, such dishes sponsor the differentiation of iPSCs into succeeding neural progenitor cells, neurons, and as the ultimate product subtype of neurons - dopaminergic neurons up to 6 months. This system is simple, modest to accomplish with lower expenses
The significance of mitochondrial biogenesis reprogramming in refractory hypotension and multi-organ dysfunction during hemorrhagic shock

Refractory hypotension following vascular hyporeactivity and multi-organ dysfunction are the major causes of mortality from severe shock and resuscitation in the clinic. Depressed contractile vasoresponsiveness and persistent hypotension not only result from insufficient microcirculatory delivery of nutrients and oxygen but also from mitochondria-derived cytopathic hypoxia. Our studies identified that mitochondrial dysfunction in arteriolar smooth muscle cells is involved in the pathogenesis of low vasoresponsiveness during hemorrhagic shock. Mitochondrial injury was also found in organ dysfunction. However, the molecular mechanism underlying mitochondria injury in the progression of hemorrhagic shock remains elusive. Discovery of mitochondrial biogenesis reprogramming and energy Correspondence/Reprint request: Dr. Rui Song, Department of Pathophysiology, Key Lab for Shock and Microcirculation Research of Guangdong Province, Southern Medical University, Guangzhou 510515, China E-mail: songrui110@126.com Rui Song & Pengyun Li 124 metabolism regulation provides new insights into the mechanisms of mitochondrial damage and mitochondrial-mediated human diseases or pathologic conditions. Recently, energizing genetics and epigenetics play important role in the regulation of mitochondrial function. Histone deacetylases have been demonstrated to dramatically improve survival following lethal hemorrhagic shock, thereby providing a potential link between hemorrhagic shock injury and epigenetic regulation. The aim of this review is to highlight the role of epigenetics in multi-organ mitochondrial biogenesis reprogramming and discuss the potential of mitochondria based therapeutic approaches for the management and treatment of refractory hypotension and multi-organ dysfunction following hemorrhagic
Relationship between polymorphisms of CYP 19 A 1 gene and hypertension : a meta-analysis

Objective and Background: Several published studies have investigated the relationship between the rs700518 and rs4646 polymorphisms in the CYP19A1 gene and the risk of hypertension; however, their results were inconsistent. To examine these inconclusive findings, we performed a meta-analysis to investigate the relationships between genetic polymorphisms of the CYP19A1 gene and the risk of hypertension. Methods: By searching PubMed, ISI Web of Science and Embase, as well as the Wanfang Database, the Chinese National Knowledge Infrastructure (CNKI) Database, the Weipu Database and the Chinese Academic Journal Full-text Database, we extracted data from eligible studies and included these data in our meta-analysis. The relationships between the rs700518 and rs4646 polymorphisms and hypertension were estimated using pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Heterogeneity was investigated and measured using Cochran’s Q test and the inconsistency index (I2) test. Meta-analysis was conducted using Review Manager Software (version 5.3). Results: A total of six studies from five articles including 1446 subjects with hypertension and 1658 healthy individuals were included in this meta-analysis. No relationship was found between the rs700518 and rs4646 polymorphisms in the CYP19A1 gene and the risk of hypertension (for rs700518, allele model: A vs. G, OR = 1.03, 95% CI: 0.93-1.13, P = 0.59; dominant model: AA vs. AG+GG, OR = 1.10, 95% CI: 0.95-1.27, P = 0.20; recessive: model: GG vs. AG+AA, OR = 1.04, 95% CI: 0.88-1.22, P = 0.65; for rs4646, allele model: G vs. T, OR = 1.00, 95% CI: 0.89-1.12, P = 0.98; GG vs. dominant model: GT+TT, OR = 1.02, 95% CI: 0.88-1.18, P = 0.80; recessive model: TT vs. GT+GG, OR = 0.97, 95% CI: 0.73-1.28, P = 0.83). However, if the data were stratified by gender (men and women), a relationship between the rs4646 polymorphism in the CYP19A1 gene and the risk of hypertension among female subjects under the recessive model (TT vs. GT+GG: P = 0.04) was found using a fixed-effect model. Conclusion: The results of our meta-analysis suggest that neither the rs700518 polymorphism nor the rs4646 polymorphism in the CYP19A1 gene is a genetic marker of hypertension susceptibility. Other factors, such as gender, appear to play a role in the relationship between the rs4646 polymorphism and the risk of hypertension.
Are ocean deserts getting larger?

The spatial and temporal dynamics of ocean biomes and their provincial subdivisions are affected by the dynamics of Earth's climate system, but the effect of climate change on the distribution and variability of ocean biomes and provinces is largely unknown. A time‐series analysis from multiple satellite platforms shows that the lowest productivity provinces have been growing over the last decade and that the growth rates of these provinces increase as they get larger, and decrease as they get smaller. The most oligotrophic provinces of the ocean grow by reducing the size of the slightly less oligotrophic provinces. As a consequence, while the ocean's most extreme deserts are increasing at an accelerating rate, some oligotrophic areas are simultaneously shrinking. The aggregate area of the oligotrophic provinces oscillated in phase with the Pacific Decadal Oscillation Index from 1998–2007.
The E 2 E NLG Challenge : Training a Sequence-to-Sequence Approach for Meaning Representation to Natural Language Sentences

This paper describes one of Thomson Reuters’ primary submissions to the E2E NLG Challenge-2017 shared task. The challenge is focused on end-to-end data-driven natural language generation to learn sentences from non-aligned data. We used a state-of-the-art sequence-to-sequence method to generate natural language sentences from meaning representations. Our automatically generated sentences were evaluated both intrinsically and extrinsically.
The Gemini MCAO System GeMS: nearing the end of a lab-story

GeMS (the Gemini Multi-conjugated adaptive optics System) is a facility instrument for the Gemini-South telescope. It will deliver a uniform, diffraction-limited image quality at near-infrared (NIR) wavelengths over an extended FoV or more than 1 arcmin across. GeMS is a unique and challenging project from the technological point of view and because of its control complexity. The system includes 5 laser guide stars, 3 natural guide stars, 3 deformable mirrors optically conjugated at 0, 4.5 and 9km and 1 tip-tilt mirror. After 10 years since the beginning of the project, GeMS is finally reaching a state in which all the subsystems have been received, integrated and, in the large part, tested. In this paper, we report on the progress and current status of the different sub-systems with a particular emphasis on the calibrations, control and optimization of the AO bench.
LANDFILL SITTING USING MCDM in TEHRAN METROPOLITAN

Managing Municipal Solid Waste in order to control waste materials in Tehran Metropolitan with a population of over 8.5 million persons and daily production of 7500 tons of trash seems an evitable necessity. Daily production of such amount of trash and accumulation of them in the southern part of Tehran (Kahrizak) due to lack of proper and standard methods of landfilling have caused severe problems by creating a latex lake of twelve hectares. Among these problems, penetration of infection and contamination to underground waters, causing excessive problems for soil and agricultural lands can be mentioned. In such conditions caused for Tehran, lack of solution finding for the issue would bring heavy outcomes for the Tehran Metropolitan in terms of environmental and economic issues. In this paper, efforts are taken to find a new place as a landfill by applying sustainable development approach. For this, in order to use the criteria propounded in sustainable development, multi-criteria decision making methods has been applied for weighing and spatial analysis has been used to combining them for indicating the most appropriate site. In this way, the new site would be selected by observance of sustainable development would be a place with the least environmental and social damages while being economically affordable.
Tribological properties of protic ionic liquid and functionalized copper oxide nanoparticles as additives to base oil

The aim of the present study was to investigate a novel composite as lubricant additive for metal wear parts, composing of protic ionic liquid and functionalized copper oxide nanoparticle composite. A simple and an easy-to-modify synthesis method for the preparation of thiol cov-ered copper oxide nanoparticles was developed. A long process of optimization of reaction parameters was carried out that resulted in preparing non-agglomerated oil dis-persible copper oxide nanoparticles with an estimated av-erage diameter of 60 nanometers based on SEM measure-ments. Novel protic ionic liquid, which dissolves in oil was synthesized. Lubricant tribological experiments with the standardized four-ball-method were conducted with 15 kg. The addition of 3% ionic liquid and 0.5% copper oxide nanoparticles to base oil reduced the wear up to 35% com-pared to base oil without any additives, while 1% of protic IL reduced wear up to 47%. In addition, the novel type lubricant additive has many advantages and can also widen the range of applications, e.g. wider temperature range and preserved functionality at harsh conditions where oil-based lubricants fail. DOI: http://dx.doi. org/10.5755/j01.mech. 21.2. 11723
Using transcranial electrical stimulation to enhance cognitive functions in the typical and atypical brain

Transcranial electrical stimulation (TES) includes methods such as transcranial direct current stimulation, transcranial random noise stimulation, and transcranial alternating current stimulation. These methods provide novel ways of enhancing human cognitive abilities for restorative purposes, or for general cognitive enhancement, by modulating neuronal activity. I discuss here the basic principles behind these methods and provide some illustrations of their efficacy in cognitive enhancement in those with typical and atypical brain function. Next, I outline some future directions for research that are have been largely neglected, such as the issue of individual differences, cognitive side effects, the efficacy of TES for use with healthy elderly populations, children with atypical development, and sports. The results observed thus far with TES as well as its future possibilities have significant implications for both basic and translational neuroscience.
Key characteristics of SME procurement: An empirical study

This research is part of the i-Compete project on improving competitiveness of small and medium-sized enterprises (SMEs) in the South West of England through best practice procurement. It is jointly funded by the ERDF (through Universities South West), the Chartered Institute of Purchasing and Supply (CIPS) and supported by Beacon South West. This paper gives a brief overview of the literature before exploring whether the findings on SMEs in the South West of England supported or challenged that previous research
The effect of additional supplementation of vitamin E and zinc on endocrine and metabolic changes in dairy cows during peripartal period

The objective of this study was to measure the effect of vitamin E (Vit-E) and zinc (Zn) supplements on endocrine and metabolic changes in peripartum cows. Thirty-two crossbred (Holstein Friesian×Tharparkar) cows were selected 60 days before the expected date of calving. The cows were arbitrary allocated into 4 groups (n = 8), namely: the control, T1, T2, and T3. The feeding schedule was similar in all the groups except that in T1, T2, and T3 60 mg Zn/kg DM, 1000 IU Vit-E and 60 mg/kg + 1000 IU Zn + Vit-E were additionally added, respectively, from day 60 pre-calving to day 60 post-calving. Blood samples were taken on days 60, 45, 30, 15, and 7 before and after the expected day of calving and on the day of calving. Before calving, the cows showed a decrease in plasma leptin, insulin, glucose, Vit-E, and Zn levels, and an increase in plasma non-esterified fatty acid level. However, increases in plasma leptin, insulin, glucose, Vit-E, and Zn and a decrease of plasma nonesterified fatty acid were observed after calving. After calving, group T3 had higher (P<0.05) plasma leptin, insulin, and glucose concentrations than all the other groups. Plasma Vit-E levels were higher (P<0.05) in groups T2 and T3; however, the Zn level was higher (P<0.05) in groups T1 and T2. Milk yield was observed to be higher (P<0.05) in T3 than in the control and groups T1 and T2. The reduction in leptin, insulin, glucose, Vit-E, and Zn during peripartum was ameliorated by Vit-E and Zn supplementation.
Optimality Trade-offs For Distributed Estimation Anit

This paper proposes Communication efficient REcursive Distributed estimatiOn algorithm, CREDO, for networked multi-worker setups without a central master node. CREDO is designed for scenarios in which the worker nodes aim to collaboratively estimate a vector parameter of interest using distributed online time-series data at the individual worker nodes. The individual worker nodes iteratively update their estimate of the parameter by assimilating latest locally sensed information and estimates from neighboring worker nodes exchanged over a (possibly sparse) time-varying communication graph. The underlying inter-worker communication protocol is adaptive, making communications increasingly (probabilistically) sparse as time progresses. Under minimal conditions on the inter-worker information exchange network and the sensing models, almost sure convergence of the estimate sequences at the worker nodes to the true parameter is established. Further, the paper characterizes the performance of CREDO in terms of asymptotic covariance of the estimate sequences and specifically establishes the achievability of optimal asymptotic covariance. The analysis reveals an interesting interplay between the algorithm’s communication cost Ct (over t time-steps) and the asymptotic covariance. Most notably, it is shown that CREDO may be designed to achieve a Θ ( C t ) decay of the mean square error (ζ > 0, arbitrarily small) at each worker node, which significantly improves over the existing Θ ( C−1 t ) rates. Simulation examples on both synthetic and real data sets demonstrate CREDO’s communication efficiency.
CHEMICAL WEATHERING ,A TMOSPHERIC CO 2 , AND CLIMATE

There has been considerable controversy concerning the role of chem- ical weathering in the regulation of the atmospheric partial pressure of carbon dioxide, and thus the strength of the greenhouse effect and global climate. Arguments center on the sensitivity of chemical weathering to climatic factors, especially temperature. Laboratory studies reveal a strong dependence of mineral dissolution on temperature, but the expression of this dependence in the field is often obscured by other environ- mental factors that co-vary with temperature. In the field, the clearest correlation is between chemical erosion rates and runoff, indicating an important dependence on the intensity of the hydrological cycle. Numerical models and interpretation of the geologic record reveal that chemical weathering has played a substantial role in both maintaining climatic stability over the eons as well as driving climatic swings in response to tectonic and paleogeographic factors.
Detection of Mycobacterium Tuberculosis from Clinical Samples using Different Real-Time PCR System

ISSN: 2319-7706 Volume 7 Number 12 (2018) Journal homepage: http://www.ijcmas. com During the study period (July to December 2016) a total of 188 samples (sputum and blood from each person) have been tested in the National Reference Laboratory (NRL) at the Institute of Chest and Respiratory Diseases / Baghdad. These cases are considered as suspected pulmonary tuberculosis. This study for these 188 suspected specimens declare that, 103 (54.78%) cases were positive using direct assay (AFB smear microscopy) and 85 (45.21%) were considered to be negative cases by smear microscopy. Of the 103 TB patients, 88 (85.43%) were represented as new TB cases; the others 15 (14.57%) patients appeared to follow up assessment of the directly observed treatment (DOT) program. Detection of M. tuberculosis by real time PCR GeneXpert showed that among total 188 specimens (Suspected Group), 117(62.23%) of the specimens were positive in GeneXpert from sputum and 71 (37.76%) negative specimens by GeneXpert. This study, declares the percentage of sensitivity, specificity, PPV and NPV of GeneXpert which were 94.11 %, 92.75 %, 95.72 % and 90.14 % respectively. Detection of M. tuberculosis by real time PCR using Realline kit showed that among the total 188 specimens (Suspected Group), 112 (59.57%) of the specimens were positive and 76 (40.4%) negative which detected by Real-Time PCR using Realline Kit. All these samples are sputum. This study showed the percentage of sensitivity, specificity, PPV and NPV of Realline kit were 92.43%, 97.1%, 98.21% and 88.15 % respectively. Detection of M. tuberculosis by real time PCR using MTB Robogene kit showed that among the total 188 specimens (Suspected Group), 111 (59.04%) of the specimens were positive, and 77 (40.95%) negative specimens by using MTB Robogene kit, the samples are sputum. The sensitivity, specificity, PPV and NPV of our study was 87.3%, 89.85%, 93.69% and 80.51% respectively. Detection of M. tuberculosis by real time PCR using MTBDNA Blood showed that among total 188 specimens (Suspected Group), 59 (31.38%) were positive in PCR and 129 (68.61%) were negative, DNA was extracted directly from blood and then tested in MTB Robogene kit. The present showed the percentage of the sensitivity, specificity, PPV and NPV to be 47.89%, 97.1%, 96.6% and 51.93. K e y w o r d s