Miracle-dz/UniFAR-FTUs huggingface dataset:
SISTEMAS DE INFORMACIÓN INTER-ORGANIZACIONALES, UN CASO DE ESTUDIO

Un Sistema de Informacion Interorganizacional (SIIO) se define como la automatizacion del flujo de informacion entre organizaciones para alcanzar un sistema de administracion de la cadena de suministros deseado. Este proyecto plantea el problema de integrar flujos de informacion entre empresas afines para establecer sistemas que interconecten los procesos de negocios entre ellas. Los cuestionamientos que esta investigacion abordan si se podra establecer ese vinculo, y responder a los requerimientos de las negociaciones comerciales, cambiando la cultura organizacional y evitando volver a las practicas cotidianas de utilizar mecanismos manuales. Es posible establecer como una conclusion del caso de estudio que se puede integrar a las empresas de manera que puedan comunicarse de manera eficiente a pesar de sus diferencias tecnologicas y culturales, y que se pueden reconocer las condiciones administrativas y tecnicas para lograr la interrelacion y establecer las condiciones de colaboracion entre empresas
POPULATION GENETIC STRUCTURE OF COASTAL BOTTLENOSE DOLPHINS (TURSIOPS TRUNCATUS) IN THE NORTHERN BAHAMAS

Population substructure has important implications for a species’ ecology and evolution. As such, knowledge of this structuring is critical for the conservation and management of natural populations. Among marine mammals, many examples exist of species that enjoy a broad geographical distribution, yet are characterized by fine-scale population subdivisions. Coastal bottlenose dolphins have been studied extensively in a few regions globally, and these studies have highlighted a great diversity in both social strategies and demographic isolation. Here we use molecular genetic markers to examine the degree of population subdivision among three study sites separated by less than 250 km on Little Bahama Bank in the northern Bahamas. Mitochondrial DNA (mtDNA) sequence variation and microsatellite
Protein S-100 and neuropsychological functioning following severe traumatic brain injury

Primary objective: To examine the relationship between serum concentrations of protein S-100β and neuropsychological functioning following severe traumatic brain injury. Design: Matched control group. Methods: Blood samples were taken within 12 hours of injury and then daily up to 7 days post-injury (n = 23). Within 2 weeks of emerging from post-traumatic amnesia (PTA), participants completed a battery of neuropsychological measures. These results were compared with a matched sample of healthy controls. Results: Early measurement of S-100 not only reflected overall brain injury severity, but also related to neuropsychological deficits, with higher serum concentrations associated with poorer performance across most cognitive domains. PTA duration, measured by the Westmead PTA Scale, was found to be the strongest predictor of S-100 concentration (R2 = 0.59, p < 0.001). Conclusions: These findings show that measurement of serum protein S-100 may further aid in the identification of individuals with severe TBI who are likely to experience cognitive difficulties.
Relations between open‐field, elevated plus‐maze, and emergence tests in C57BL/6J and BALB/c mice injected with GABA‐ and 5HT‐anxiolytic agents

Two 5HT1A receptor agonists and chlordiazepoxide were examined in open‐field, elevated plus maze, and emergence tests. At doses with no effect in the open‐field, chlordiazepoxide increased open and open/total arm visits as well as open arm duration in the elevated plus maze, whereas 5HT1A receptor agonists showed an anxiolytic response on a single measure. The anxiolytic action of chlordiazepoxide was limited to the less active BALB/c strain. Unlike the 5HT1A receptor agonists, chlordiazepoxide was also anxiolytic in the emergence test, once again only in BALB/c and not C57BL/6J mice. Significant correlations were found between emergence latencies and specific indicators of anxiety in the elevated plus‐maze in chlordiazepoxide‐treated but not in mice treated with buspirone and 8‐OH‐DPAT. These results indicate that elevated plus‐maze and emergence tests depend on benzodiazepine receptors. In contrast, 5HT1A receptor agonists were ineffective in the emergence test and no correlation was found between emergence latencies and specific indicators of anxiety in the elevated plus‐maze. Though superficially similar, the emergence test seems to tap into a partially separate facet of anxiety.
Systems approach to explore components and interactions in the presynapse

The application of proteomic techniques to neuroscientific research provides an opportunity for a greater understanding of nervous system structure and function. As increasing amounts of neuroproteomic data become available, it is necessary to formulate methods to integrate these data in a meaningful way to obtain a more comprehensive picture of neuronal subcompartments. Furthermore, computational methods can be used to make biologically relevant predictions from large proteomic data sets. Here, we applied an integrated proteomics and systems biology approach to characterize the presynaptic (PRE) nerve terminal. For this, we carried out proteomic analyses of presynaptically enriched fractions, and generated a PRE literature‐based protein–protein interaction network. We combined these with other proteomic analyses to generate a core list of 117 PRE proteins, and used graph theory‐inspired algorithms to predict 92 additional components and a PRE complex containing 17 proteins. Some of these predictions were validated experimentally, indicating that the computational analyses can identify novel proteins and complexes in a subcellular compartment. We conclude that the combination of techniques (proteomics, data integration, and computational analyses) used in this study are useful in obtaining a comprehensive understanding of functional components, especially low‐abundance entities and/or interactions in the PRE nerve terminal.
Optimization of Processor Clock Frequency for Sensor Network Nodes Based on Energy Use and Timing Constraints

The effectiveness of sensor networks depends critically on efficient power management of the sensor nodes. Dynamic voltage frequency scaling (DVFS) and dynamic power management (DPM) have been proposed to enable energy-efficient scheduling for real-time and embedded systems. However, most power-aware scheduling algorithms are designed to deal with only those cases in which the task execution time is determined solely by the clock frequency of the processor. In this study, we propose an extended task execution model that is appropriate for the sensor nodes and an algorithm that determines the optimal clock frequency for a node's processor. We analyze the extended model and verify that our algorithm calculates the clock frequency that optimizes energy savings while satisfying the timing constraints.
New and emerging diseases--the wildlife interface.

Emerging diseases are defined as those that have newly appeared in a population or that have existed but are increasing in incidence or geographical range. Most emergencies occur because of a breakdown in the barriers that previously limited the geographic or host range of the disease agent. Infectious diseases appear to flourish in disrupted environments. There are about 200 species of wild mammal and > 500 species of wild bird in Canada. These provide a potentially rich pool of new disease agents and disease hosts, which is increased further by the introduction of new species from other areas of the world. Several factors influence the involvement of wild animals in disease emergence; a) the introduction of new disease agents with translocated wild animals; for example, rabies moved with racoons (Procyon lotor) and coyotes (Canis latrans) that were translocated for hunting in the USA; Echinococcus multilocularis was translocated with foxes (Vulpes vulpes) to the southeastern USA; Fasciolides magna moved with elk (Cervus elaphus) from North America to Europe; and chronic wasting disease moved with farmed elk; b) the introduction of a disease agent that becomes established in indigenous wild animals; for example, the establishment of West Nile virus in eastern North American birds and of plague in wild rodents in western North America; c) the introduction of a wild animal that alters the ecology of an existing disease; for example, the brush-tailed possum (Trichosurus vulpecula) introduced to New Zealand became the major reservoir for bovine tuberculosis; d) environmental change that favors range expansion or population increase of wild animals involved in a disease; for example, habitat changes have resulted in increased deer and tick populations associated with the emergence of Lyme disease; environmental changes have led to expanded populations of double-crested cormorant (Phalacrocorax auritus) and epizootics of Newcastle disease; and range expansion of raccoons has introduced Baylisascaris procyonis to the prairie provinces; e) changes in land use that bring humans, domestic animals, and wild animals into closer contact; and f) changes in human activities that alter disease transmission; for example, the impact of artificial feeding on the maintenance of bovine tuberculosis in white-tailed deer (Odocoileus virginianus) in Michigan and brucellosis in some elk populations; and the occurrence of mycoplasmosis and salmonellosis in songbirds associated with backyard feeders. The involvement of wild animals may complicate management of a newly emerged disease in several ways, including the difficulty in detecting the occurrence of the disease or disease agent in wild animals compared with in human or domestic animal populations, the difficulty in implementing standard disease control measures in free-ranging animals, the need to involve many agencies with different mandates, and public resistance to disease measures that are perceived to be harmful to a publicly owned and highly treasured resource.
The synaptic cytoskeleton in development and disease

The cytoskeleton forms the backbone of neuronal architecture, sustaining its form and size, subcellular compartments and cargo logistics. The synaptic cytoskeleton can be categorized in the microtubule‐based core cytoskeleton and the cortical membrane skeleton. While central microtubules form the fundamental basis for the construction of elaborate neuronal processes, including axons and synapses, cortical actin filaments are generally considered to function as mediators of synapse dynamics and plasticity. More recently, the submembranous network of spectrin and ankyrin molecules has been involved in the regulation of synaptic stability and maintenance. Disruption of the synaptic cytoskeleton primarily affects the stability and maturation of synapses but also secondarily disturbs neuronal communication. Consequently, a variety of inherited diseases are accompanied by cytoskeletal malfunctions, including spastic paraplegias, spinocerebellar ataxias, and mental retardation. Since the primary reasons for many of these diseases are still unknown model organisms with a conserved repertoire of cytoskeletal elements help to understand the underlying biological mechanisms. The astonishing technical as well as genetic accessibility of synapses in Drosophila has shown that loss of the cytoskeletal architecture leads to axonal transport defects, synaptic maturation deficits, and retraction of synaptic boutons, before synaptic terminals finally detach from their target cells, suggesting that similar processes could be involved in human neuronal diseases. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 111–125, 2012
Non-linear finite element analysis for electronic packages subjected to combined hygroscopic and thermo-mechanical stresses

A finite element modeling scheme to analyze the combined effect of thermal and hygroscopic deformation is presented. The scheme employs the conventional moisture diffusion and heat transfer analysis capabilities available in the commercial FEM packages, but a new formulation is introduced to allow the time-dependent non-linear analysis of package deformations induced by hygroscopic as well as thermal expansion mismatches. Validity of modeling scheme is verified using time-dependent displacement fields of a bi-material specimen documented by real-time moire interferometry
The expanded family of class II cytokines that share the IL‐10 receptor‐2 (IL‐10R2) chain

Several novel interleukin (IL)‐10‐related cytokines have recently been discovered. These include IL‐22, IL‐26, and the interferon‐λ (IFN‐λ) proteins IFN‐λ1 (IL‐29), IFN‐λ2 (IL‐28A), and IFN‐λ3 (IL‐28B). The ligand‐binding chains for IL‐22, IL‐26, and IFN‐λ are distinct from that used by IL‐10; however, all of these cytokines use a common second chain, IL‐10 receptor‐2 (IL‐10R2; CRF2‐4), to assemble their active receptor complexes. Thus, IL‐10R2 is a shared component in at least four distinct class II cytokine‐receptor complexes. IL‐10 binds to IL‐10R1; IL‐22 binds to IL‐22R1; IL‐26 binds to IL‐20R1; and IFN‐λ binds to IFN‐λR1 (also known as IL‐28R). The binding of these ligands to their respective R1 chains induces a conformational change that enables IL‐10R2 to interact with the newly formed ligand‐receptor complexes. This in turn activates a signal‐transduction cascade that results in rapid activation of several transcription factors, particularly signal transducer and activator of transcription (STAT)3 and to a lesser degree, STAT1. Activation by IL‐10, IL‐22, IL‐26, or IFN‐λ can be blocked with neutralizing antibodies to the IL‐10R2 chain. Although IL‐10R2 is broadly expressed on a wide variety of tissues, only a subset of these tissues expresses the ligand‐binding R1 chains. The receptors for these cytokines are often present on cell lines derived from various tumors, including liver, colorectal, and pancreatic carcinomas. Consequently, the receptors for these cytokines may provide novel targets for inhibiting the growth of certain types of cancer.
E-procurement maturity in industry

This paper aims to examine the use and implementation of electronic procurement for indirect material in eight large global companies, and investigate what kinds of barriers exist towards electronic procurement. The empirical evidence comes from interviews with e-procurement experts and operatives in eight global firms. Results show that three out of eight companies are using e-procurement and four are planning to do so in the future. Barriers shown by the empirical material are lack of technological standard, different IT-maturity among suppliers, resistance among users to leaving old suppliers, lack of support from top management, differences in language, culture and legal systems. Other barriers found are getting suppliers to update and control the electronic product catalogues and to monitor them and getting the users in the organisation to use the system.
Educational playgrounds

• Users may freely distribute the URL that is used to identify this publication. • Users may download and/or print one copy of the publication from the University of Birmingham research portal for the purpose of private study or non-commercial research. • User may use extracts from the document in line with the concept of ‘fair dealing’ under the Copyright, Designs and Patents Act 1988 (? ) • Users may not further distribute the material nor use it for the purposes of commercial gain.
Contour based visualization of vessel movement predictions

We present a visualization method for the interactive exploration of predicted positions of moving objects, in particular, ocean-faring vessels. Two simple prediction models, one based on similarity to historical trajectories and one on Monte Carlo simulation, are presented. The prediction models generate temporal probability density fields starting from a known situation. We use contours to visualize spatio-temporal zones of these density fields. Predictions are split into a configurable number of segments for which we render one or more contours. Users, investigating and exploring the possible development of a situation, can see where a vessel will be in the near future according to a given prediction model. Through a number of real-world use cases and a discussion with users, we show our methods can be used in monitoring traffic for collision avoidance, and detecting illegal activities, like piracy or smuggling. By applying our methods to pedestrian movements, we show that our methods can also be applied to a different domain.
Study of Genetic Association With DCDC2 and Developmental Dyslexia in Hong Kong Chinese Children

Background: Doublecortin domain-containing 2 (DCDC2) is a doublecortin domain-containing gene family member and the doublecortin domain has been demonstrated to bind to tubulin and enhance microtubule polymerization. It has been associated with developmental dyslexia and this protein family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Objectives: The objective of the study is to find out if there is any association of genetic variants of DCDC2 with developmental dyslexia in Chinese children from Hong Kong. Methods: The dyslexic children were diagnosed as developmental dyslexia (DD) using the Hong Kong Test of Specific Learning Difficulties in Reading and Writing (HKT-SpLD) by the Department of Health, Hong Kong. Saliva specimens were collected and their genotypes of DCDC2 were studied by DNA sequencing or TaqMan Real Time PCR Assays. Results: The most significant marker is rs6940827 which is associated with DD with nominal p-value (0.011). However, this marker did not remain significant after multiple testing corrections and the adjusted p-value from permutation test was 0.1329. Using sliding window haplotype analysis, several haplotypes were found to be nominally associated with DD. The smallest nominal p values was 0.0036 (rs2996452-rs1318700, C-A). However, none of the p values could withstand the multiple testing corrections. Conclusion: Despite early findings that DCDC2 is a strong candidate for developmental dyslexia and that some of the genetic variants have been linked to brain structure and functions, our findings showed that DCDC2 is not strongly associated with dyslexia.
Sodium Bicarbonate Ingestion and Boxing Performance

Siegler, JC and Hirscher, K. Sodium bicarbonate ingestion and boxing performance. J Strength Cond Res 24(1): 103-108, 2010-Boxing is a sport that consists of multiple high-intensity bouts separated by minimal recovery time and may benefit from a pre-exercise alkalotic state. The purpose of this study was to observe the ergogenic potential of sodium bicarbonate (NaHCO3) ingestion on boxing performance. Ten amateur boxers volunteered to participate in 2 competitive sparring bouts. The boxers were prematched for weight and boxing ability and consumed either 0.3 g·kg−1 body weight (BW) of NaHCO3 (BICARB) or 0.045 g·kg−1 BW of NaCl placebo (PLAC) mixed in diluted low calorie-flavored cordial. The sparring bouts consisted of four 3-minute rounds, each separated by 1-minute seated recovery. Blood acid-base (pH, bicarbonate [HCO3−], base excess [BE]), and performance (rates of perceived exertion [RPE], heart rate [HR] [HRave and HRmax], total punches landed successfully) profiles were analyzed before (where applicable) and after sparring. The results indicated a significant interaction effect for HCO3− (p ≤ 0.001) and BE (p < 0.001), but not for pH (p = 0.48). Post hoc analysis revealed higher presparring HCO3− and BE for the BICARB condition, but no differences between the BICARB and PLAC conditions postsparring. There was a significant increase in punches landed during the BICARB condition (p < 0.001); however, no significant interaction effects for HRave (p = 0.15), HRmax (p = 0.32), or RPE (p = 0.38). The metabolic alkalosis induced by the NaHCO3 loading elevated before and after sparring blood buffering capacity. In practical application, the findings suggest that a standard NaHCO3 loading dose (0.3 g·kg−1) improves punch efficacy during 4 rounds of sparring performance.
Axon‐Schwann cell interactions regulate the expression of c‐jun in Schwann cells

The transcription factor c‐jun is selectively expressed by non‐myelinating Schwann cells in normal peripheral nerve, and by “denervated,” previously myelinating Schwann cells, after axotomy. When axons regenerate into the distal nerve‐stump, the expression of c‐jun declines as Schwann cells remyelinate axons. Treating cultured Schwann cells with forskolin, a drug that mimics many of the effects of axon‐Schwann cell interactions, decreases the expression of c‐jun but increases the expression of myelin‐specific genes. Overexpressing c‐jun in cultured Schwann cells, however, does not decrease the expression of a myelin basic protein promoter‐reporter construct, indicating that c‐jun expression may not directly regulate myelin‐specific gene expression. These data suggest that c‐jun is involved in regulating the phenotype of non‐myelinating and denervated Schwann cells. © 1996 Wiley‐Liss, Inc.
Poissons nouveaux ou peu connus provenant de La Réunion et de Madagascar

11 existe a La Reunion une petite espece rarement capturee vu son site profond, entre 150 et 250 m, et sa taille exigue. Nous n’en avons pris jusqu’g present qu’une dizaine d’exemplaires, dont un seul exemplaire depassant 150 mm de longueur standard. Cette espece est remarquable par un anneau vermillon de 3 ecailles de large%environ qui entoure l’extremite posterieure du pedoncule caudal, par la longueur de ses barbillons qui atteignent la base des ventrales. Sa caudale est generalement jaune vif, mais parfois rose, son corps allonge, robuste, est rouge ainsi que toutes ses autres nageoires.
Identification of volatile organic compounds in leaves, roots and gum of Astragalus compactus Lam. using solid phase microextraction followed by GC-MS analysis

A solid phase microextraction sampling method using pencil-lead fibre coupled with gas chromatography-mass spectrometry was used to monitor the organic volatile compounds of the roots, leaves and gum of Astragalus compactus. Under optimised conditions, a range of volatile compounds were recognised in different parts of A. compactus. Based on the results obtained, the nature and level of the volatiles vary in distinct parts of the plant. In comparison with other Astragalus species investigated, only one volatile organochlorine compound, tetradecane,1-chloro, was identified in roots. Intriguingly, the toxic chlorinated component was not detectable in the gum samples. These findings highlight the higher quality of the gum of A. compactus compared to the gums of some other Astragalus species, which are reported to be contaminated with chlorinated components.
Strains of Escherichia coli belonging to serogroups O157 and O55 express lipopolysaccharides that are structurally distinct and do not share common epitopes.

ganglioside antibodies with lipopolysaccharide fractions of Campylobacter jejuni isolates from patients with Guillain-Barré syndrome (GBS). J Neuroimmunol 1997;73:28–36. 7. Jacobs BC, Endtz HP, van der Meché FGA, Hazenberg MP, de Klerk MA, van Doorn PA. Humoral immune response against Campylobacter jejuni lipopolysaccharides in Guillain-Barré and Miller Fisher syndrome. J Neuroimmunol 1997;79:62–8. 8. Ogino M, Orazio N [sic], Latov N. IgG anti-GM1 antibodies from patients with acute motor neuropathy are predominantly of the IgG1 and IgG3 subclasses. J Neuroimmunol 1995;58:77–80. 9. Heidenreich F, Leifeld L, Jovin T. T cell–dependent activity of ganglioside GM1–specific B cells in Guillain-Barré syndrome and multifocal motor neuropathy in vitro. J Neuroimmunol 1994;49:97–108. Reprints or correspondence: Dr. Nobuhiro Yuki, Dept. of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293, Japan (n_yuki@msn.com).