Miracle-dz/UniFAR-FTUs huggingface dataset:
Domain Analysis of the Calcium-activated Potassium Channel SK1 from Rat Brain

Two small conductance, calcium-activated potassium channels (SK channels), SK2 and SK3, have been shown to contribute to the afterhyperpolarization (AHP) and to shape the firing behavior in neurons for example in the hippocampal formation, the dorsal vagal nucleus, the subthalamic nucleus, and the cerebellum. In heterologous expression systems, SK2 and SK3 currents are blocked by the bee venom toxin apamin, just as well as the corresponding neuronal AHP currents. However, the functional role and pharmacological profile of SK1 channels from rat brain (rSK1) is still largely unknown, as so far rSK1 homomeric channels could not be functionally expressed. We have performed a domain analysis to elucidate the pharmacological profile and the molecular determinants of rSK1 channel expression by using channel chimeras in combination with immunocytochemistry, immunoblot analysis, and electrophysiology. Our results reveal that the rSK1 subunit is synthesized in cells but does not form functional homomeric channels. Exchanging the carboxyl terminus of rSK1 for that of hSK1 or rSK2 is sufficient to rescue the functional expression of rSK1 channels. Additionally, transplantation of both amino and carboxyl termini of rSK1 onto hSK1 subunits, normally forming functional homomeric channel, hinders their functional expression, while hSK1 channels containing only the rSK1 carboxyl terminus are functional. These results suggest that the lack of functional expression of rSK1 channels is probably due to problems in their assembly and tetramerization but not in their calmodulin-dependent gating. Finally, we show that chimeric channels containing the core domain (S1–S6) of rSK1, unlike hSK1, are apamin-insensitive.
Tomosar platform supports for Sentinel-1 tops persistent scatterers interferometry

Developing and improving methods to monitor both natural and non-natural environments such as forest and urban in space and time is a timely challenge. To overcome this challenge, we created a software platform — TomoSAR. The kernel of this platform supports the entire processing from SAR, Interferometry, Polarimetry, to Tomography (so called TomoSAR). The objective of this paper is to introduce this platform about its capability in Persistent Scatterers Interferometry (PSI) technique to estimate subsidence using TOPS Sentinel-1 data.
Dwelling into Service Innovation Management Practices: A Comparison Between Telecommunication Industry in Malaysia and Bangladesh

In the multifaceted as well as vibrant telecommunications industry, service innovation management is a relatively new paradigm, which has attracted the attention of scholars and practitioners. Thus, this study embarks on to compare the practices of service innovation management between Malaysia and Bangladesh telecommunications industry. The strategy, process, organization, tool/technology and system (SPOTS) model with 26 indicators was employed to compare the management practices among these two countries. A total of 176 managers (98 from Malaysia and 78 from Bangladesh) participated in this research through survey questionnaires. An independent-samples t-test was conducted to compare the 26 indictors on management practices for Malaysian and Bangladesh telecommunications industry. The findings indicated that the management practices were operationalized differently in these two countries. Bangladesh put more emphasis on each of the innovation management practices when compared to Malaysia. It indicates that innovation management is practiced more in the country where the market is in the process of development. The results enable the firms to better compete in an environment which requires innovative changes and global discipline. In fact, the findings provide guidelines for the service sectors in both countries in terms of implementation of innovative enterprises, especially in Bangladesh where innovation is the basis for survival.
Cinnamon bark extract improves glucose metabolism and lipid profile in the fructose-fed rat.

INTRODUCTION The present study was designed to investigate whether cinnamon bark extract (CBEt) mitigates the adverse effects of fructose loading on glucose metabolism and lipid profile in rats. METHODS Adult male albino rats of body weight 150-170 g were divided into five groups and fed with either control or high fructose diet (HFD). CBEt was administered to HFD-fed rats orally at two doses (a low and a high dose) while the control diet-fed rats were treated with a high dose of CBEt. The treatment protocol was carried out for 60 days after which the oral glucose tolerance test was carried out. Biochemical parameters related to glucose metabolism and lipid profile were assayed. RESULTS The levels of glucose, insulin and protein-bound sugars were higher and activities of enzymes of glucose metabolism were altered in HFD-fed rats, as compared to control animals. The levels were brought back to near-normal when administered with CBEt at high dose. CBEt also prevented the hyperlipidaemia observed in fructose-fed rats and improved glucose tolerance. CBEt did not show any significant effect in fructose-fed rats when administered at low dose. CONCLUSION These findings indicate the improvement of glucose metabolism in-vivo by CBEt in fructose-fed rats.
High blood pressure and endothelial dysfunction: effects of high blood pressure medication on endothelial dysfunction and new treatments

Hypertension is one of the most common chronic medical conditions and to this day has remained one of the important problems of public health. Because of relationship between endothelial dysfunction, atherosclerosis and high blood pressure, returning the endothelium-dependent vasodilatation is known as one of the important goals of treatment for high blood pressure. Drugs should be able to preserve endothelial function and reduce blood pressure. This has caused the most recent treatments and strategies to improve endothelial function. We review the mechanism of these drugs on endothelial function. Most of the drugs have a positive effect on improving endothelial function and the role of dihydropyridine calcium channel inhibitors such as nifedipine is obvious. Most studies showed lack of adequate control of blood pressure by monotherapy. A combination of calcium channel blockers and angiotensin converting enzyme has been proposed. The use of new drugs such as antioxidant, aldosterone antagonists and the pro-angiogenic factors with nonpharmacologic and pharmacologic therapy, can reduce blood pressure and has a significant impact on the function of epithelium.
An electrical description of the generation of slow waves in the antrum of the guinea‐pig

This paper provides an electrical description of the generation of slow waves in the guinea‐pig gastric antrum. A short segment of a circular smooth muscle bundle with an attached network of myenteric interstitial cells of Cajal (ICC‐MY) and longitudinal muscle sheet was modelled as three electrical compartments with resistive connexions between the ICC‐MY compartment and each of the smooth muscle compartments. The circular smooth muscle layer contains a proportion of intramuscular interstitial cells of Cajal (ICC‐IM), responsible for the regenerative component of the slow wave. Hence the equivalent cell representing the circular muscle layer incorporated a mechanism, modelled as a two stage reaction, which produces an intracellular messenger. The first stage of the reaction is proposed to be activated in a voltage‐dependent manner as described by Hodgkin and Huxley. A similar mechanism was incorporated into the equivalent cell describing the ICC‐MY network. Spontaneous discrete transient depolarizations, termed unitary potentials, are detected in records taken from either bundles of circular smooth muscle containing ICC‐IM or from ICC‐MY. In the simulation the mean rate of discharge of unitary potentials was allowed to vary with the concentration of messenger according to a conventional dose–effect relationship. Such a mechanism, which describes regenerative potentials generated by the circular muscle layer, also simulated the plateau component of the pacemaker potential in the ICC‐MY network. A voltage‐sensitive membrane conductance was included in the ICC‐MY compartment; this was used to describe the primary component of the pacemaker potential. The model generates a range of membrane potential changes with properties similar to those generated by the three cell types present in the intact tissue.
B‐type Natriuretic Peptides in Acute Coronary Syndromes: Implications in an Aging Population

B‐type natriuretic peptide (BNP) and N‐terminal‐proBNP (NT‐proBNP) are increasingly recognized as prognostic markers in patients with acute coronary syndrome (ACS). The need for novel and more effective tools for risk assessment cannot be more emphasized than in older patients with ACS given their atypical presentation, multiple comorbidities, and higher risk for mortality and morbidity. Accurate interpretation of B‐type NP values in older patients with ACS, however, may be confounded by several aging‐related physiologic changes. Advanced age, reduction in body mass, and kidney function and anemia have been associated with higher BNP and NT‐proBNP concentrations, and may create challenges with interpreting NP levels in the elderly. This review highlights the need to better understand the physiology of BNP and NT‐proBNP in older individuals and their prognostic value in older patients with ACS. Clin. Cardiol. 2012 doi: 10.1002/clc.22035
Birth control pills and nonprofessional voice: acoustic analyses.

PURPOSE Two studies are presented here. Study 1 was aimed at evaluating whether the voice characteristics of women who use birth control pills that contain different progestins differ from the voice characteristics of a control group. Study 2 presents a meta-analysis that combined the results of Study 1 with those from 3 recent studies that compared voices of women who use and do not use birth control pills. METHOD In Study 1, voice samples from 30 women with no history of voice training, who use pills with different progestins (drospirenone, desogestrel, gestodene), and 10 women who do not use the pill were recorded at specific time points across the menstrual cycle and were analyzed acoustically. In Study 2, results from Study 1 were analyzed jointly with results from three recent studies, which used similar methodologies. RESULTS Results of Study 1 did not reveal acoustic differences in sustained phonation of vowels across the pill groups and controls. Results of the meta-analysis performed in Study 2 indicated that pill users exhibited lower jitter and shimmer values on sustained vowels, whereas no difference of fundamental frequency was observed among women who use the pill. CONCLUSIONS These results support findings from previous studies, which suggested that no adverse effect on voice was detected among nonprofessional speakers who use new-generation monophasic birth control pills, for the measures studied. Furthermore, results of the meta-analysis suggested that some acoustic properties of the voice, which are reflected in perturbation measures in sustained vowels, may be improved among women who use the pill.
Developments in the treatment of juvenile arthritis

Although rarely a life-threatening disease, juvenile arthritis (JA) can, if poorly controlled, profoundly affect growth, development and quality of life in children. Long-term damage in children with JA rarely arises from overly aggressive therapy, but rather from an overly conservative and cautious approach in the early stages of the disease. As more potential therapeutic agents for JA become available, the physician must become skilled in viewing the data with a critical eye with regard to safety and efficacy in the paediatric population. The following review discusses the prognosis and management of JA, with a focus on new emerging agents for the treatment of this disease.
Modeling Money Demand in China: Evidence from Cointegration Analysis

When monetary policy is not aimed at clearing the money market by using the nominal interest rate, as in China's case, money demand becomes an important analytical tool. This paper examines China's money demand in the long run with the cointegration analysis. We find that (i) real money balances is a function of real income and interest rate in the long run; (ii) real money balances react positively to changes in real income while negatively to those in interest rate in the long run; (iii) the impact of economic activity on real money demand is large while that of the interest rate is relatively small. Our finding implies that monetary aggregates in China have some useful indicator properties and monetary authorities should watch its movement closely.
Study on short-range transmission of UWB signals

This work focuses on transmission of UWB signals through a closely-spaced antenna pair. The spatial distribution of the electrical field strength in the vicinity of a single antenna is investigated. The power budget of a transmission through a near-field coupled antenna pair is analyzed. Different mutual positions and distances between the antennas have been investigated. It was found that the reactive antenna coupling might decrease power budget as much as 15 dB by an antenna separation of 5 mm
WAR 39 ETHICS AND ACCOUNTING EDUCATION: FEW RELEVANT ISSUES

The demand for accounting graduates to fulfill the corporate needs is increasing from day to day. Education is a platform to prepare them to face challenging roles of the profession. There were various ethical cases involve accounting and accounting-based professionals. It is believed that most accounting corporate scandals and crisis happened due to lack of ethical values exercised by accounting talents in carrying their duties and responsibilities. This study empirically discusses the findings of related literatures on ethics and accounting education. The study focuses on the relevant issues, namely teaching approach, i.e. ethics as a single course or embedded in other accounting courses; contents of ethics in accounting curriculum as well as the qualification and readiness of the instructors to teach ethics. Few scholars representing Islamic education, accounting education, Malaysian accreditation agency and Malaysian accounting professional body were interviewed to get feedbacks on the issues, particularly in Malaysian accounting education systems. It was found that ethics as a single course or vice versa has their own pros and cons. Meanwhile, the contents of ethics course vary, with the most efficient method is to include real ethical cases for students to analyze. Finally, as far as the qualification of the ethics instructor is concerned, it is hard to find the qualified person to teach ethics since the instructor need to both having the spirit of ethics in them and mastering the accounting syllabus itself as well as the issues surrounding the accounting profession.
Treatment of premature ejaculation

Premature ejaculation (PE) is a common problem, the treatment of which has received an increasing interest in recent years. Traditional management continues to be psychotherapy, with techniques such as the ‘squeeze’ and ‘stop‐start’ most commonly employed. The application of local anaesthetics to the glans to delay ejaculation, first described over 60 years ago, continues to be used both in medical practice and as an ‘over‐the‐counter’ remedy. Over the years, a variety of psychopharmacological agents, especially antidepressants, have been described as treatments for PE. At the present time, the selective serotonin re‐uptake inhibitors, licensed for other indications, emerge as the most effective agents to delay ejaculation, but none are licensed for the treatment of PE. There appears to be a high relapse rate irrespective of the mode of therapy used.
The involvement of clathrin‐mediated endocytosis and two Sid‐1‐like transmembrane proteins in double‐stranded RNA uptake in the Colorado potato beetle midgut

RNA interference (RNAi) is a powerful tool in entomology and shows promise as a crop protection strategy, but variability in its efficiency across different insect species limits its applicability. For oral uptake of the double‐stranded RNA (dsRNA), the RNAi trigger, two different mechanisms are known: systemic RNA interference deficient‐1 (Sid‐1) transmembrane channel‐mediated uptake and clathrin‐mediated endocytosis. So far, a wide range of experiments has been conducted, confirming the involvement of one of the pathways in dsRNA uptake, but never both pathways in the same species. We investigated the role of both pathways in dsRNA uptake in the Colorado potato beetle, Leptinotarsa decemlineata, known to have an efficient RNAi response. Through RNAi‐of‐RNAi experiments, we demonstrated the contribution of two different sid‐1‐like (sil) genes, silA and silC, and clathrin heavy chain and the 16kDa subunit of the vacuolar H+ ATPase (vha16), elements of the endocytic pathway, to the RNAi response. Furthermore, the sid‐1‐like genes were examined through phylogenetic and hydrophobicity analysis. This article reports for the first time on the involvement of two pathways in dsRNA uptake in an insect species and stresses the importance of evaluating both pathways through a well‐devised reporter system in any future experiments on cellular dsRNA uptake.
Induction of Relational Schemas: Common Processes in Reasoning and Complex Learning

Five experiments were performed to test whether participants induced a coherent representation of the structure of a task, called a relational schema, from specific instances. Properties of a relational schema include: An explicit symbol for a relation, a binding that preserves the truth of a relation, potential for higher-order relations, omnidirectional access, potential for transfer between isomorphs, and ability to predict unseen items in isomorphic problems. However relational schemas are not necessarily coded in abstract form. Predictions from relational schema theory were contrasted with predictions from configural learning and other nonstructural theories in five experiments in which participants were taught a structure comprised of a set of initial-state,operator-->end-state instances. The initial-state,operator pairs were presented and participants had to predict the correct end-state. Induction of a relational schema was achieved efficiently by adult participants as indicated by ability to predict items of a new isomorphic problem. The relational schemas induced showed the omnidirectional access property, there was efficient transfer to isomorphs, and structural coherence had a powerful effect on learning. The "learning to learn" effect traditionally associated with the learning set literature was observed, and the long-standing enigma of learning set acquisition is explained by a model composed of relational schema induction and structure mapping. Performance was better after reversal of operators than after shift to an alternate structure, even though the latter entailed more overlap with previously learned tasks in terms of the number of configural associations that were preserved. An explanation for the reversal shift phenomenon in terms of induction and mapping of a relational schema is proposed. The five experiments provided evidence supporting predictions from relational schema theory, and no evidence was found for configural or nonstructural learning theories.
MinimalRNN: Toward More Interpretable and Trainable Recurrent Neural Networks

We introduce MinimalRNN, a new recurrent neural network architecture that achieves comparable performance as the popular gated RNNs with a simplified structure. It employs minimal updates within RNN, which not only leads to efficient learning and testing but more importantly better interpretability and trainability. We demonstrate that by endorsing the more restrictive update rule, MinimalRNN learns disentangled RNN states. We further examine the learning dynamics of different RNN structures using input-output Jacobians, and show that MinimalRNN is able to capture longer range dependencies than existing RNN architectures.
Pilot-less high-rate block transmission with two-dimensional basis expansion model for doubly-selective fading MIMO systems

We investigate non-coherent multi-antenna signal processing which requires no channel state information (CSI) at either transmitter or receiver ends. With non-coherent constellations over Grassmannian manifold, a receiver employing generalized likelihood ratio test (GLRT) algorithm offers the maximum-likelihood performance even without CSI. The conventional GLRT relies on the assumption that the wireless channel is time-invariant during a block. We propose an improved GLRT algorithm which employs a novel two-dimensional basis expansion model (2D-BEM) to cope with doubly-selective fading channels. The proposed method uses sequential GLRT for multisymbol detection to keep high performance yet low complexity. Furthermore, we introduce Fourier-Legendre product basis to be robust against hardware impairments including carrier frequency and timing offsets. We demonstrate that the proposed scheme significantly improves performance in rapid fading channels, and realizes highly spectrum-efficient transmission up to 6 bps/Hz without any pilots.
Adaptive frequency rolling for coexistence in the unlicensed band

Frequency Hopping (FH) technology has been widely used for short-range networks operating in unlicensed band. As the short-range FH networks gain momentum in ubiquitous usage, the interference that collocated FH networks cause to each other, termed self-interference, becomes one of the major sources that degrade the communication performance. This paper proposes the Adaptive Frequency Rolling (AFR), a particular adaptive instance of FH that enables FH networks to cooperate and effectively avoid the self-interference. The AFR uses as input solely the observed packet error rate (PER) and it does not require any exchange of information among the collocated networks. The effect of the AFR over a longer time interval is that the networks use the complete set of disposable channels in an implicit time-division and cooperative manner. The parameter choice is such that a network which uses AFR never occupies the channels in the unlicensed spectrum more than what is permitted by the current regulation. AFR is designed to be robust towards the noise-induced channel errors. We also design AFR with probing (AFR-P), a modified version of AFR, which can also overcome frequency-static interference from collocated non-FH network by introducing channel removal strategy with probing. Our simulation results show that AFR and AFR-P have superior goodput performance to pseudorandom frequency hopping (PFH), and also standard adaptive frequency hopping (AFH), where the latter is designed to exclusively combat frequency-static interference. All these features promote the great potential of AFR as a coexistence mechanism for unlicensed operation