Miracle-dz/UniFAR-FTUs huggingface dataset:
Gray matter structural compromise is equally distributed in left and right temporal lobe epilepsy

In drug‐resistant temporal lobe epilepsy (TLE), MRI studies have shown consistent mesiotemporal and neocortical structural alterations when comparing patients to healthy controls. It remains, however, relatively unclear whether the side of seizure focus differentially impacts the degree of structural damage. This work performed a comprehensive surface‐based analysis of mesiotemporal and neocortical morphology on preoperative 1.5 T MRI in 25/35 LTLE/RTLE patients that achieved seizure freedom after surgery (i.e., Engel‐I outcome; 7 ± 2 years follow‐up), an imaging‐independent confirmation of focus lateralization. Compared to 46 age‐ and sex‐matched controls, both TLE groups displayed marked ipsilateral atrophy in mesiotemporal regions, while cortical thinning was bilateral. Direct contrasts between LTLE and RTLE did not reveal significant differences. Bootstrap simulations indicated low reproducibility of observing a between‐cohort difference; power analysis revealed that more than 110 patients would be necessary to detect subtle differences. No difference between LTLE and RTLE was confirmed when using voxel‐based morphometry, an independent proxy of gray matter volume. Similar results were obtained analyzing a separate 3 T dataset (15/15 LTLE/RTLE patients; Engel‐I after 4 ± 2 years follow‐up; 42 controls). Our results strongly support equivalent gray matter compromise in left and right TLE. The morphological profile of seizure‐free patients, presenting with ipsilateral mesiotemporal and bilateral cortical atrophy, motivates the development of neuromarkers of outcome that consider both mesiotemporal and neocortical structures. Hum Brain Mapp 37:515–524, 2016. © 2015 Wiley Periodicals, Inc.
B2b or Not to Be: Does B2b E-Commerce Increase Labour Productivity?

We implement an endogeneous switching-regression model for labour productivity and firms' decision to use business-to-business (B2B) e-commerce. Our approach allows B2B usage to affect any parameter of the labour productivity equation and to properly take account of strategic complementarities between the input factors and B2B usage. Empirical evidence from 1,394 German firms shows that firms using B2B e-commerce have a significantly higher output elasticity with respect to ICT-investment and produce significantly more efficiently than firms that do not use B2B. Firms' labour productivity is enhanced by using B2B.
[Anxiety and depression in patients with obstructive diseases].

UNLABELLED Obstructive disorders (asthma and chronic obstructive pulmonary disease) are associated with considerable emotional burden of the patient, with may result in the development of mood disturbances and anxiety disorders. However, the literature data are contradictory. The aim of the study was to assess the correlation between subjective and objective obstruction symptoms and the intensity of anxiety as a condition, as well as estimation of the intensity of anxiety and depression in patients suffering from obstructive syndromes. MATERIAL AND METHODS The study enrolled 32 patients diagnosed with obstructive disorders. Structuralized anamnesis was obtained and spirometry was performed in compliance with the standards set by the Polish Society of Lungs Diseases. Disturbances of ventilation and their severity were estimated according to the GINA Report and GOLD Guidelines. All the patients were assessed using Beck Depression Inventory and Spielberg State - Trait Anxiety Inventory (STAI). The subjective dyspnoea levels were estimated with Borg scale. The study was carried out between October 2005 and September 2008 in the Specialist Outpatient Department of the Łódź Medical University Department of Pneumonology and Allergology. RESULTS A weak positive correlation was demonstrated between the declared dyspnoea level and the intensity of depression (p < 0.05) as well as the intensity of anxiety as a condition (p < 0.05) and anxiety as a trait (p < 0.05). A weak negative correlation was found to exist between FVC EX and the level of anxiety as condition (p < 0.01) and anxiety as a trait (p < 0.05). No statistically significant correlations between the values of spirometric parameters: FEV1, FEV1%, FEV1%FVC, and the levels of depression, anxiety and reported dyspnoea were found. CONCLUSIONS A positive correlation between the declared dyspnoea level and the intensity of anxiety and depression as a condition was demonstrated in the studied group of patients with obstructive disorders.
PURIFICATION OF TUBULIN AND ASSOCIATED HIGH MOLECULAR WEIGHT PROTEINS FROM PORCINE BRAIN AND CHARACTERIZATION OF MICROTUBULE ASSEMBLY IN VITRO *

Explanations are required for the post-translational mechanisms that determine the initiation, growth, directionality, and spatial localization of microtubules. To analyze these problems experimentally, attempts have been made to establish polymerization systems in vitro in which the molecular components that regulate microtubule assembly might be identified. Because of the biochemical nature of this problem, brain tissue, which contains abundant microtubule protein, was chosen as the experimental material. Comparative biochemistry has shown that tubulin from diverse cell types has similar properties (see Olmsted and Borisy,' Stephens,? and Wilson and Bryan for reviews): therefore, the findings of studies on brain tubulin may be applicable to cytoplasmic microtubules in general. The purpose of this report is to describe the purification of tubulin and associated high-molecular-weight proteins, and the characteristics of microtubule polymerization in vitro. In this paper, we will discuss some of the factors that might be involved in the general regulation of the assembly process. Specifically, the following questions will be considered: (1) Are proteins other than tubulin associated with microtubules? (2) How do environmental conditions, such as ionic strength and pH, affect polymerization? ( 3 ) What role do nucleotides have in polymerization? (4) Do divalent cations inhibit or stimulate assembly? (5) Is tubule assembly in vitro an equilibrium process? (6) What is the overall mechanism of tubule assembly? (7) Are intermediates involved in the initiation and growth of tubules?
Linked Data Meets Ontology Matching - Enhancing Data Linking through Ontology Alignments

The Web of data consists of publishing data on the Web in such a way that they can be connected together and interpreted. It is thus critical to establish links between these data, both for the Web of data and for the Semantic Web that it contributes to feed. We consider here the various techniques which have been developed for that purpose and analyze their commonalities and differences. This provides a general framework that the diverse data linking systems instantiate. From this framework we consider the relation between data linking and ontology matching activities. Although, they can be considered similar at a certain level (they both relate formal entities), they serve different purposes: one acts at the schema level and the other at the instance level. However, they would find a mutual benefit at collaborating. We thus present a scheme under which it is possible for data linking tools to take advantage of ontology alignments. We present the features of expressive alignment languages that allows linking specifications to reuse ontology alignments in a natural way.
Long‐term prognostic implications of nonoptimal primary angioplasty for acute myocardial infarction

Aim: To evaluate the long‐term outcome of a nonoptimal result of a primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). Methods and Results: An optimal PCI result was defined as TIMI flow grade 3 and residual stenosis ≤≤≤≤20%. Long‐term clinical follow‐up (51 ±± 21 months) data were collected from 1,009 consecutive patients with ST‐elevation AMI who underwent primary PCI. Overall, an optimal primary PCI result was achieved in 958 patients (95%). At 5‐year follow‐up, patients with nonoptimal PCI had a higher rate of all‐cause mortality (47% vs 19%; P < 0.00001 by log‐rank test) than those with an optimal mechanical reperfusion. Fifty‐two percent of the deaths in the nonoptimal PCI group occurred within the first month. Interestingly, after this period, estimated survival of 30‐day alive patients was not significantly different to that of patients with an optimal PCI (P = 0.06 by log‐rank test). Nonoptimal PCI result emerged as an independent predictor of 1‐month mortality (OR = 3.030, 95% CI = 1.265–7.254; P = 0.013), but not of 5‐year mortality. At long‐term follow‐up, comulative rates of nonfatal reinfarction, hospitalization for heart failure, and additional revascularization procedures were similar between patients with nonoptimal and optimal primary PCI (4% vs 5%, P = 0.695; 4% vs 5%, P = 921; and 22% vs 20%, P = 0.816, respectively). Conclusion: A nonoptimal primary PCI result represents a strong predictor of early mortality. However, in patients surviving the early phase, the incidence of clinical events at long‐term follow‐up seems to be similar to successfully reperfused AMI patients. © 2006 Wiley‐Liss. , Inc.
Appearance concerns and psychosocial adjustment following head and neck cancer: A cross-sectional study and nine-month follow-up

Psychosocial difficulties have been reported in head and neck cancer (HNC) patients, yet only few studies have assessed the impact of altered appearance following HNC treatment using theoretically selected measures of appearance-related distress. This study investigated appearance-related adjustment following HNC, and demographic and socio-cognitive predictors of adjustment. HNC patients (n = 49) completed baseline questionnaires and a nine-month postal follow-up (n = 20). Participants showed considerable variation in appearance-related adjustment, with females reporting higher levels of appearance-related distress (derriford appearance scale [DAS-24]) than females in the general population and male HNC survivors. Depression scores on the hospital anxiety and depression scale were higher than UK norms whilst anxiety was similar to UK norms. There were no significant differences between baseline and follow-up data. Fear of negative evaluation (a central feature of social anxiety) was a significant predictor of appearance-related adjustment at baseline, whilst dispositional optimism was a significant predictor of appearance-related adjustment at baseline and follow-up. Qualitative responses showed themes of appearance and disability, and coping strategies. Findings suggest that appearance-related adjustment post-HNC varies considerably and psychosocial services working with HNC patients should consider this broad pattern of response. Future research to examine the role of socio-cognitive predictors of appearance-related adjustment could progress development of effective psychological interventions.
WITHIN‐HOST COMPETITION IN GENETICALLY DIVERSE MALARIA INFECTIONS: PARASITE VIRULENCE AND COMPETITIVE SUCCESS

Abstract Humans and animals often become coinfected with pathogen strains that differ in virulence. The ensuing interaction between these strains can, in theory, be a major determinant of the direction of selection on virulence genes in pathogen populations. Many mathematical analyses of this assume that virulent pathogen lineages have a competitive advantage within coinfected hosts and thus predict that pathogens will evolve to become more virulent where genetically diverse infections are common. Although the implications of these studies are relevant to both fundamental biology and medical science, direct empirical tests for relationships between virulence and competitive ability are lacking. Here we use newly developed strain‐specific real‐time quantitative polymerase chain reaction protocols to determine the pairwise competitiveness of genetically divergent Plasmodium chabaudi clones that represent a wide range of innate virulences in their rodent host. We found that even against their background of widely varying genotypic and antigenic properties, virulent clones had a competitive advantage in the acute phase of mixed infections. The more virulent a clone was relative to its competitor, the less it suffered from competition. This result confirms our earlier work with parasite lines derived from a single clonal lineage by serial passage and supports the virulencecompetitive ability assumption of many theoretical models. To the extent that our rodent model captures the essence of the natural history of malaria parasites, public health interventions which reduce the incidence of mixed malaria infections should have beneficial consequences by reducing the selection for high virulence.
BMP-2 immobilized PCL/P3ANA nanofibers for bone tissue engineering

Poly (ε-caprolactone)/poly (m-anthranilic acid) (PCL/P3ANA) nanofibers were fabricated by electrospinning. Nanofibers were biofuctionalized with Bone morphogenic protein-2 (BMP-2) with 1-ethyl-3-(dimethyl-aminopropyl) carbodiimide hydrochloride (EDC)/N-hydroxyl succinimide (NHS) surface activation of carboxyl groups (-COOH) on PCL/P3ANA scaffold. The structure of nanofibers was investigated by FTIR-ATR spectroscopy. The amount of bound protein was determined by BCA protein assay. In vitro cell culture studies were conducted by using human osteocarsinoma cell line (SAOS-2) and protein immobilized PCL/P3ANA nanofibers as tissue engineering scaffolds. Cell viability and proliferation assays were performed in order to understand the cell behaviour against PCL/P3ANA nanofibers. Fluorescence staining of F-actin was performed to observe the cell morphology. Alkaline phoshotase (ALP) activity of SAOS-2 cells were investigated. The results confirmed the successful immobilization of BMP-2 on the PCL/P3ANA nanofibers which can be used in bone tissue engineering.
Endogenous and exogenous catalase in reoxygenation lung injury.

Reexpansion pulmonary edema parallels reperfusion (reoxygenation) injuries in other organs in that hypoxic and hypoperfused lung tissue develops increased vascular permeability and neutrophil infiltration after reexpansion. This study investigated endogenous lung catalase activity and H2O2 production during hypoxia (produced by lung collapse) and after reoxygenation (resulting from reexpansion), in addition to assessing the effects of exogenous catalase infusion on the development of unilateral pulmonary edema after reexpansion. Lung collapse resulted in a progressive increase in endogenous catalase activity after 3 (14%) and 7 days (23%), while activities in contralateral left lungs did not change (normal left lungs averaged 180 +/- 11 units/mg DNA). Tissue from control left lungs released H2O2 into the extracellular medium at a rate calculated to be 242 +/- 34 nmol.h-1.lung-1. No significant change in extracellular release of H2O2 occurred after 7 days of right lung collapse. However, after reexpansion of the previously collapsed right lungs for 2 h, H2O2 release from both reexpanded right and contralateral left lungs significantly increased (88 and 60%, respectively) compared with controls. Infusion of exogenous catalase significantly increased plasma and lung catalase activities. Exogenous catalase infusion prevented neither the increase in lung permeability nor the infiltration with neutrophils that typically occurs in reexpanded lungs. These data indicate that lung hypoxia/reoxygenation, induced by sequential collapse and reexpansion, has specific effects on endogenous lung catalase activity and H2O2 release. However, exogenous catalase does not prevent reexpansion pulmonary edema, eliminating extracellular (but not intracellular) H2O2 as an important mediator of unilateral lung injury in this model.
A Study to Assess the Energy Saving Potential and Economic Analysis of an Agro Based Industry in Karnataka, India

Agro based industries in India are considered as the micro, small and medium enterprises (MSME). In India, MSMEs contribute approximately 8 percent of the country’s GDP, 42 percent of the manufacturing output and 40 percent of exports. The toor dal (scientific name Cajanus cajan, commonly known as yellow gram, pigeon pea) is the second largest pulse crop in India accounting for about 20% of total pulse production. The toor dal milling industry in India is one of the major agro-processing industries in the country. Most of the dal mills are concentrated in pulse producing areas, which are spread all over the country. In Karnataka state, Gulbarga is a district, where toor dal is the main crop and is grown extensively. There are more than 500 dal mills in and around the Gulbarga district to process dal. However, the majority of these dal milling units use traditional methods of processing which are energy and capital intensive. There exists a huge energy saving potential in these mills. An energy audit is conducted on a dal mill in Gulbarga to understand the energy consumption pattern to assess the energy saving potential, and an economic analysis is conducted to identify energy conservation opportunities. Keywords—Conservation, demand side management, load curve, toor dal.
The Effects of Time Course after Anterior Cruciate Ligament Injury in Correlation with Meniscal and Cartilage Loss

In this study, 130 consecutive patients with anterior cruciate ligament insufficiency who were undergoing ligament reconstruction underwent arthroscopic examination at the time of reconstruction, and any loss of meniscal or chondral integrity was documented in a systematic fashion. In these patients, a greater proportion of the medial meniscus was lost compared with the lateral meniscus (16% versus 5%). On average, 6 cm2 of the articular cartilage was damaged (5.2 cm 2) or lost (0.8 cm2), with the area of damage and loss greatest on the medial femoral condyle. Patients whose injuries had occurred more than 2 years before the examination had more than sixfold greater cartilage loss and damage compared with those whose injuries had occurred within the past 2 months. Meniscal loss was associated with a threefold increase in cartilage damage or loss. The group of patients with meniscal loss whose initial anterior cruciate ligament injury occurred more than 2 years before examination exhibited 18 times the amount of cartilage loss or damage as did the group that had no meniscal loss and whose injury occurred less than 1 month before examination.
Anomalous behavior of bacteriophage lambda polypeptides in polyacrylamide gels: resolution, identification, and control of the lambda rex gene product

The resolution of lambia proteins was compared on the two types of sodium dodecyl sulfate-polyacrylamide gels commonly in use. The two kinds of gel differ essentially in the ratio of the cross-linker, N'-N-bismethylene-acrylamide (bisacrylamide), to acrylamide monomer. Several lambda proteins migrate relatively more slowly in gels with high bisacrylamide/acrylamide ratios (HB gels) than in gels with low ratios, although the two types of gel are of roughly equivalent porosity. This effect is illustrated by a change in relative position of both the Rex and Int proteins, with apparent increases in molecular weight of about 8 and 15%, respectively, in the HB gels. This work confirms that like repressor and Int, the 28.5-kilodalton protein, identified as Rex on HB gels, is postively regulated by the lambdacII and cIII products and negatively controlled Cro. An intact y site is required for Rex and repressor expression after infection, whereas their synthesis in a lysogen is dependent upon a functional maintenance promoter, Prm.
Band-Distributed Channel-Aware Fractional Frequency Reuse in OFDMA Systems

Fractional frequency reuse (FFR) has been actively studied in order to reduce inter-cell interference, especially for cell edge users in current orthogonal frequency division multiple access systems. However, the best resource block (RB) allocation to the edge users is limited by conventional FFR, which has sub- bands consisting of contiguous RBs. In this paper, we propose a band-distributed FFR scheme that effectively employs channel quality information (CQI) by fully exploiting frequency diversity to mitigate this limitation. In this scheme, the entire system bandwidth is divided into two classes of sub-bands that comprise non-contiguous RBs. Our analysis shows that the proposed band- distributed FFR has better performance than the conventional FFR for various environments defined in IMT-Advanced models. Moreover, the gain with our scheme increases as the coherent bandwidth (Bc) increases.
Applications of Real-Time Simulation Technologies in Power and Energy Systems

Real-time (RT) simulation is a highly reliable simulation method that is mostly based on electromagnetic transient simulation of complex systems comprising many domains. It is increasingly used in power and energy systems for both academic research and industrial applications. Due to the evolution of the computing power of RT simulators in recent years, new classes of applications and expanded fields of practice could now be addressed with RT simulation. This increase in computation power implies that models can be built more accurately and the whole simulation system gets closer to reality. This Task Force paper summarizes various applications of digital RT simulation technologies in the design, analysis, and testing of power and energy systems.
Neuropsychological sequelae of cardiac arrest.

OBJECTIVES Prospective and community-based studies on the cognitive outcome of out-of-hospital cardiac arrest have not been published. We studied prospectively the neuropsychological sequelae of cardiac arrest and evaluated the effects of nimodipine on them. DESIGN Placebo-controlled, randomized, double-blind trial of nimodipine compared with placebo in out-of-hospital ventricular fibrillation. SETTING Urban area of 500,000 inhabitants served by the physician-manned Advanced Life Support Unit of Helsinki. PATIENTS A total of 155 successfully resuscitated consecutive patients out of 677 resuscitation attempts during 2 1/2 years. Sixty-eight survivors were examined by a neuropsychologist and a neurologist. MAIN OUTCOME MEASURE Neuropsychological outcome 3 months and 1 year after cardiac arrest. INTERVENTIONS Nimodipine or placebo at a dosage of 10 micrograms/kg as an intravenous injection immediately after restoration of spontaneous circulation, followed by an infusion of 0.5 micrograms/kg per minute for 24 hours. RESULTS Three months after cardiac arrest, 41 (60%) of 68 patients were found to have moderate to severe cognitive deficits. At 12 months, 26 (48%) of 54 survivors still had moderate to severe deficits, and the Symptom Check List 90--Revised score indicated the presence of depression in 22 patients (45%) and severe depression in 12 patients (24%). CONCLUSIONS Moderate to severe neuropsychological sequelae of out-of-hospital cardiac arrest are still present in approximately one half of the survivors at 1 year and may be permanent. There seems to be no excess of increased disability in the subgroup of patients with delayed advanced life support. Nimodipine failed to show any effect on the cognitive functions tested.
Human walking assist control on level ground

Our walking motion control is designed for the purpose of supporting persons who have handicaps. The way of control design is differ from robot control. Simple control, easy sensing and operating are required. Therefore swing leg motion control is introduced. This paper is addressed as 1) control design, 2) walking simulation, and 3)analysis of human walking with our proposing method