Miracle-dz/UniFAR-FTUs huggingface dataset:
Dasatinib Reversibly Disrupts Endothelial Vascular Integrity by Increasing Non-Muscle Myosin II Contractility in a ROCK-Dependent Manner

Purpose: Dasatinib is a short-acting dual ABL/SRC family tyrosine kinase inhibitor (TKI), which is frequently used to treat chronic myeloid leukemia. Although very effective, patients taking dasatinib often display severe adverse effects, including pleural effusions and increased risk of bleeding primarily in the gastrointestinal tract. The actual causes of these side effects are currently undetermined. We hypothesize that endothelial cells (ECs) that line the inner walls of blood vessels and control the traffic to the underlying tissues might be involved. Experimental Design: The effects of TKIs on ECs were studied by various assays, such as real-time cell impedance measurements, live-cell microscopy, wound healing, Western blot, and an in vivo model. Results: Dasatinib uniquely causes a profound, dose-dependent disorganization of the EC monolayers. Dasatinib promoted the disassembly of cell–cell contacts, altered cell–matrix contacts, and further altered the wound healing. A key observation is that this effect is fully reversible after drug washout. In line with these in vitro observations, intraperitoneal administration of dasatinib to mice caused significant vascular leakage in the intestine. The underlying molecular mechanism of dasatinib-induced reorganization of the actin involves ROCK activation, which increases the amount of the phosphorylation of myosin light chain and consequently activates the non-muscle myosin II. Conclusions: Our data are consistent with a scenario in which dasatinib triggers a transient increase in vascular leakage that probably contributes to adverse effects such as bleeding diathesis and pleural effusions. Clin Cancer Res; 23(21); 6697–707. ©2017 AACR.
A study on Latest Management Governance Techniques in Indian Companies

Management cum governance is considered as a proactive controlling mechanism for protecting best interests of all the stakeholders of any companies. Despite a lot of initiatives has been taken around the world in the form of codes / laws for ensuring good governance for corporate sector, the issue of mutual fund governance had not been discussed in detail. But, in view of the growth of that industry and the magnitude of public funds the mutual fund companies are managing over the years, a renewed interest on its governance mechanism is the need of the hour. Here, in this paper, an attempt has been made to enquire the governance practices of Indian mutual fund industries. After studying the governance structure of asset management companies (AMCs) of the sample mutual fund companies, it was found that the structure and composition of board of directors of these AMCs were not encouraging enough with a little and sometimes no information about the functioning of the board of these AMCs. Under this circumstance, measures for improvement of governance and disclosure standards are expected from regulatory body like SEBI.
Differential distribution of glycine transporters in Müller cells and neurons in amphibian retinas

Amphibian retinas are commonly used for electrophysiological studies on neural function and transduction because they share the same general properties as higher vertebrate retinas. Glycinergic synapses have been well described in amphibian retinas. However, the role of glycine transporters in the synapses is largely unknown. We studied the distribution and function of glycine transporters in the retinas from tiger salamanders, mudpuppies, and leopard frogs by immunofluorescence labeling and whole-cell recording methods. Our results indicated that GlyT1- and GlyT2-like transporters were present in Müller cells and neurons, respectively. GlyT1 labeling was present in Müller glial cells and co-localized with Glial fibrillary acidic protein (GFAP), a Müller cell marker, whereas the GlyT2 immunoreactivity was present in the somas of amacrine cells (ACs) and processes in the inner plexiform layer (IPL) and the outer plexiform layer (OPL). Because the axon processes of glycinergic interplexiform cells (IPCs) are the only source of glycine input in the OPL, GlyT2 staining revealed a spatial pattern of the axon processes of IPCs in the OPL. The function of GlyT2 in the IPCs was studied in tiger salamander retinal horizontal cells (HCs) by whole-cell gramicidin perforated recording. The results demonstrated that inhibition of GlyT2 by a specific inhibitor, amoxapine, increased a tonic glycine input to HCs. Thus, the GlyT2 transporter is responsible for uptake of synaptic glycine in the outer retina. We also compared the distribution of glycine transporters in other amphibian species: salamander, mudpuppy, and frog. The results are consistent with the general pattern that GlyT1-like transporters are present in Müller cells and GlyT2-like transporters in neurons in amphibian retinas.
Power and performance management via model predictive control for virtualized cluster computing

There is growing research interest in the power and performance management problem for the virtualized computing systems (most data centers) today. In such systems, multiple control actions are feasible, including turning on or off the machine, creating, destroying or migrating the virtual machines, adjusting the frequency of processor etc. In this paper, a novel discrete system state model is built, in which almost all the control actions as well as the time delay effect can be reflected by the state transition. Based on the model, the performance and power can be defined on each state. Then, the model predictive controller is implemented and validated by dynamically minimizing the quadratic cost function which integrate the quality of performance tracking and power saving. Experiment results show that by choosing a moderate weight between performance and power, performance can be well tracked (the requirement being satisfied for 99% times) and power consumption can be saved significantly (by 33%) on average compared with the system without the controller.
Dynamic capabilitites and growth strategy sustainability : A case-study of Russian high-growth private companies

Companies operating in emerging markets face highly turbulent and complex environments. Russia is no exception; the firms acting on the Russian market perform in the conditions of economic instability, energy export dependence, state bureaucratic constraints and unfair competition from the part of oligarchic groups. However, despite all these challenges, more and more private owned companies manage to enjoy high growth and margins. A critical group of firms are the so-called high-growth private companies. These firms arouse special interest since they are believed to be main growth generators and, particularly in Russia, could become a key to new economic growth model. Operating in a highly turbulent Russian market requires companies to adopt and continually develop their strategies to quickly changing conditions in order to sustain growth and stay competitive in the long term. This can be achieved with the help of dynamic capabilities which serve as one of the sources of sustainable competitive advantage. However, there is a lack of research on Russian high-growth private companies and their growth strategies, even in Russian academic circles. The purpose of this study is to explain the sustainability of growth strategy by describing the linkages between Russian high-growth private companies’ dynamic capabilities, choice of growth strategy and sustainability of this growth strategy. This was studied through a qualitative multiple-case study of five Russian high-growth private companies within the IT-industry, which is one of the most rapidly developing industries in Russia. Interviews with CEOs and managers of the companies together with secondary data represent the gathered empirical data. Key issues such as companies’ dynamic capabilities, growth strategies, competitive advantages as well as the sustainability of companies’ strategies were analysed based on the empirical data. The results of the study indicate that the sustainability of company’s growth strategy depends on (1) combination of different strategic scopes (2) growth strategy foundation on company’s dynamic capabilities (3) sustainability of competitive advantage it provides (4) successful management of all the interconnected dimensions of growth. All five case companies possess sustainable competitive advantages and pursue sustainable growth strategies with a number of potential weaknesses. The study contributes to the knowledge of Russian high-growth private companies and their growth strategies as well as sustainability of growth strategies. Finally, we make recommendations for the case companies based on the results. Companies can sustain growth by building new competences and making certain changes to the existing strategies.
Jumping translocations of the long arms of chromosome 1 in myeloid malignancies is associated with a high risk of transformation to acute myeloid leukaemia *

transplantation. Bone Marrow Transplantation, 43, 429–431. Kyttälä, S. , Habermann, I. , Minami, T. , Ehninger, G. & Kiani, A. (2009) Regulation of Down Syndrome Critical Region 1 expression by Nuclear Factor of activated T cells in megakaryocytes. British Journal of Haematology, 144, 395–408. Malinge, S. , Izraeli, S. & Crispino, J.D. (2009) Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome. Blood, 113, 2619–2628. O’Connell, R.M. , Rao, D.S. , Chaudhuri, A.A. , Boldin, M.P., Taganov, K.D. , Nicoll, J., Paquette, R.L. & Baltimore, D. (2008) Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. Journal of Experimental Medicine, 205, 585–594. Ruiz-Argüelles, G.J., Ruiz-Argüelles, A. & Garcés-Eisele, J. (2007) Donor cell leukaemia: a critical review. Leukaemia & Lymphoma, 48, 25–38. Salek-Ardakani, S. , Smooha, G. , de Boer, J., Sebire, N.J., Morrow, M. , Rainis, L. , Lee, S. , Williams, O. , Izraeli, S. & Brady, H.J. (2009) ERG is a megakaryocytic oncogene. Cancer Research, 69, 4665– 4673. Sevilla, J., Querol, S. , Molines, A. , González-Vicent, M. , Balas, A. , Carrió, A. , Estella, J., Angel Dı́az, M. & Madero, L. (2006) Transient donor cell derived myelodysplastic syndrome with monosomy 7 after unrelated cord blood transplantation. European Journal of Haematology, 77, 259–263.
Prognostic Value of Primary Tumor FDG Uptake for Occult Mediastinal Lymph Node Involvement in Clinically N2/N3 Node-negative Non–Small Cell Lung Cancer

Objectives:The objective of this study was to identify predictive factors of occult mediastinal nodal involvement on staging positron emission tomography with 18F-fluorodeoxyglucose in patients with non–small cell lung cancer. Methods:We performed a retrospective review of 665 patients with suspected non–small cell lung cancer who underwent staging positron emission tomography with 18F-fluorodeoxyglucose from January 1, 2000 through August 31, 2010 at the Hospital of the University of Pennsylvania with clinical stage I or II disease and no evidence of N2 or N3 involvement on staging positron emission tomography (PET). A total of 201 of these patients underwent invasive pathologic staging of the mediastinum at the Hospital of the University of Pennsylvania with pathology reports available at the time of review. Results:A total of 63 of the 201 patients were found to have N2 disease at the time of pathologic staging. The mean standardized uptake value (SUV) of the primary tumor for patients with occult N2 metastases was significantly higher than the node-negative patients (SUV 9.31 vs. 7.24, P=0.04). Histology, tumor location (central vs. peripheral), sex, and age were not predictive for occult N2 disease. A multivariate analysis was performed and identified primary tumor SUV>6 was the only significant predictor (P=0.02). An analysis by quartile identified a primary tumor SUV>10 to have an odds ratio of 1.72 compared with an SUV<4 of occult N2 involvement. Conclusions:Increased primary tumor SUV predicted for increased risk of mediastinal nodal disease. Tumor location was not predictive of PET-occult mediastinal nodal involvement, in contrast to previous publications. Pathologic staging of the mediastinum should be strongly considered in these patients even with a negative mediastinum on PET.
Retinoblastoma Protein Contains a C-terminal Motif That Targets It for Phosphorylation by Cyclin-cdk Complexes

ABSTRACT Stable association of certain proteins, such as E2F1 and p21, with cyclin-cdk2 complexes is dependent upon a conserved cyclin-cdk2 binding motif that contains the core sequence ZRXL, where Z and X are usually basic. In vitro phosphorylation of the retinoblastoma tumor suppressor protein, pRB, by cyclin A-cdk2 and cyclin E-cdk2 was inhibited by a short peptide spanning the cyclin-cdk2 binding motif present in E2F1. Examination of the pRB C terminus revealed that it contained sequence elements related to ZRXL. Site-directed mutagenesis of one of these sequences, beginning at residue 870, impaired the phosphorylation of pRB in vitro. A synthetic peptide spanning this sequence also inhibited the phosphorylation of pRB in vitro. pRB C-terminal truncation mutants lacking this sequence were hypophosphorylated in vitro and in vivo despite the presence of intact cyclin-cdk phosphoacceptor sites. Phosphorylation of such mutants was restored by fusion to the ZRXL-like motif derived from pRB or to the ZRXL motifs from E2F1 or p21. Phospho-site-specific antibodies revealed that certain phosphoacceptor sites strictly required a C-terminal ZRXL motif whereas at least one site did not. Furthermore, this residual phosphorylation was sufficient to inactivate pRB in vivo, implying that there are additional mechanisms for directing cyclin-cdk complexes to pRB. Thus, the C terminus of pRB contains a cyclin-cdk interaction motif of the type found in E2F1 and p21 that enables it to be recognized and phosphorylated by cyclin-cdk complexes.
OF STARCH GRAFT COPOLYMERS

Starch graft copolymers are expected to become increasingly important as industrial and consumer chemicals in a large variety of end uses. Therefore, a quick and accurate analytical characterization of the graft copolymer is desirable. Vinyl side chains from starch-vinyl graft copolymers have preViously been isolated by several methods. Brockway (1) hydrolyzed the starch moiety with 1 N HCl at reflux temperature for 4-6 hr and recovered the vinyl side chains; such vigorous treatment, however, can alter sensitive functional groups of many vinyl polymers. Fanta et al. (2) treated starch-vinyl graft copolymers with ex-amylase at 50°C for 5 hr to hydrolyze the starch moiety, but hydrolysis was often incomplete in highly grafted copolymers. More recently, Gugliemelli et al. (3-5) have shown that periodate-oxidized starch depolymerizes in anhydrous methyl alcohol at room temperature with catalytic amounts of sodium methoxide to yield water-soluble compounds. This reaction sequence was used to remove the starch moiety from a number of starch graft copolymers. Since the reported procedures for analyzing starch graft copolymers are time-eonsuming or give incomplete results, we investigated a new method for decomposition and removal of the starch moiety in starch·vinyl graft copolymers based on the rapid oxidation of starch with perchloric acid in a glacial acetic acid medium.
DETERMINANTS OF CAPITAL STRUCTURE IN SMALL AND MEDIUM-SIZED ENTERPRISES IN MALAYSIA A thesis submitted for the degree of Doctor of Philosophy

ii TABLE OF CONTENTS iv ACKNOWLEDGEMENT xi DEDICATION xii DECLARATION xiv CHAPTER 1: INTRODUCTION 1.1 Background to the study 1 1.2 Research problem and rationale for the study 2 1.3 Purpose of the study 5 1.4 Overview of the methodology 6 1.5 Overview of the contribution of the research 7 1.6 Structure of the thesis 7 CHAPTER 2: LITERATURE REVIEW 2.
Categorical Perception for Unfamiliar Faces

Robust findings show that categorical perception (CP) occurs in identification of familiar faces. CP has also been observed for unfamiliar morphed faces after sufficient learning of the original, unmorphed faces has taken place. We previously suggested that CP arises when the activation of inconsistent visual and verbal representations creates a conflict between perceptual and category information. In the present study, we conducted two experiments in which the endpoint faces of an unfamiliar morphed continuum were presented in either a covert training regime (famous vs. nonfamous judgments) or an overt training regime (previously seen vs. unseen judgments). In both experiments, participants’ reaction times to repeated targets decreased relative to reaction times to control items during training. After overt training, CP was observed for the previously unfamiliar faces. No CP was observed for covertly trained faces. We conclude that individual faces must be explicitly categorized before CP can be established for the morphed continuum between them.
Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme.

BACKGROUND AND DESIGN To conduct a prospective case-control study about causative factors of severe bullous erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis, we needed to define criteria for classifying the cases and standardize the collection of data so that cases could be reliably diagnosed according to this classification. Based on review of case histories and photographs of patients, a group of experts proposed a classification based on the pattern of erythema multiforme-like lesions (categorized as typical targets, raised or flat atypical targets, and purpuric macules) and on the extent of epidermal detachment. An atlas illustrating this classification that included photographs and schematic drawings was developed. We compared the evaluations of 28 cases by four nonphysicians relying on the atlas with the evaluations of the same cases by five experts not using the atlas to determine the usefulness of this atlas for classifying cases according to our nosologic schema. RESULTS The following consensus classification in five categories was proposed: bullous erythema multiforme, detachment below 10% of the body surface area plus localized "typical targets" or "raised atypical targets"; Stevens-Johnson syndrome, detachment below 10% of the body surface area plus widespread erythematous or purpuric macules or flat atypical targets; overlap Stevens-Johnson syndrome-toxic epidermal necrolysis, detachment between 10% and 30% of the body surface area plus widespread purpuric macules or flat atypical targets; toxic epidermal necrolysis with spots, detachment above 30% of the body surface area plus widespread purpuric macules or flat atypical targets; and toxic epidermal necrolysis without spots, detachment above 10% of the body surface area with large epidermal sheets and without any purpuric macule or target. Using the atlas, the nonexperts showed excellent agreement with the experts. CONCLUSION This study suggests that an illustrated atlas is a useful tool for standardizing the diagnosis of acute severe bullous disorders that are attributed to drugs or infectious agents. Whether the five categories proposed represent distinct etiopathologic entities will require further epidemiologic and laboratory investigations.
A trust-based access control scheme for social networks

The personal data being published on online social networks is presenting new challenges in sharing of this digital content. This thesis proposes an access control scheme called Personal Data Access Control, or PDAC, which allows users to share data among their friends, using a trust computation to determine which friends should be given access. This trust computation uses previous interactions among a user’s friends to classify his or her peers into one of three protection zones, which determine whether that peer gains access to the user’s data. Additionally, the user may designate certain friends as attesters who will aid the user in determining which peers are trustworthy enough to be given access to his or her data. Simulations of the PDAC scheme were performed to evaluate its effectiveness in enforcing data access privileges. The results show that PDAC preserves confidentiality by exploiting the trust that is captured in existing social networks.
In vivo induction of murine cytokine production by carcinoembryonic antigen.

Carcinoembryonic antigen (CEA) may promote experimental metastasis through production of cytokines. The effect of systemic CEA on the production of proinflammatory cytokines was investigated in mice and compared to levels induced by lipopolysaccharide (LPS). Serum concentrations of interleukin (IL)-6 peaked 1 h after an i.v. CEA injection of 40 microg/mouse to 37-54% of the maximal level induced by a 1 microg/mouse injection of LPS in both normal and immunoincompetent mice. The CEA induction of IL-6 was a specific response, because the peptide PELPK (the pentapeptide on CEA that is the ligand for the CEA receptor on Kupffer cells) conjugated to albumin induced 30% of the maximal CEA response for IL-6, whereas the specificity control PELGK-conjugated albumin did not. IL-1alpha and tumor necrosis factor (TNF)-alpha levels after i.v. injection of CEA were only 3-5% of those induced by LPS. The IL-6 responses of mice pretreated with 100 microg/kg genistein were decreased by more than 40%. However, genistein inhibited the TNF-alpha response to LPS by 46% but increased the CEA-induced response by 300%. When murine Kupffer cells were stimulated with LPS or CEA in vitro, LPS increased tyrosine phosphorylation of a Mr 30,000 protein, whereas CEA decreased phosphorylation of a Mr 60,000 protein and did not increase phosphorylation of the Mr 30,000 protein. Thus, i.v. CEA stimulates production of IL-6 and TNF-alpha after binding to Kupffer cells through signal transduction pathways that appear to be different from those stimulated by LPS.
An analysis of satisfaction among the customers and Successful factors of Customer Relationship Management

Abstract The study provides empirical evidence in the context of Customer Relationship Management in banking sector at Tiruchirappalli Corporation. This paper is an attempt to analyse the various successful factors of CRM and the level of satisfaction among the customers, which is often been overlooked. The researcher explored the factors of CRM which influence the satisfaction among the customers. Findings indicate that customer acquisition and customer value is the major factor that is proficient in the bank. However Customer responses are needed more attention by the employees of the bank. These factors influence the customer satisfaction and loyalty. In today’s competitive environment, customers’ expectations are reaching the heights that bankers are unable to predict. To overcome this, banks have to focus on customer retention and earning new customers through attractive services by innovating and developing differentiated products.