Miracle-dz/UniFAR-FTUs huggingface dataset:
Research advances in fault diagnosis and prognostic based on deep learning

Aiming to condition based maintenance for complex equipment, numerous intelligent fault diagnosis and prognostic methods based on machine learning have been researched. Compared with the traditional shallow models, which have problems of lacking expression capacity and existing the curse of dimensionality, using deep learning theory can effectively mine characteristics and accurately recognize the health condition. In consequence, fault diagnosis and prognostic based on deep learning have turned into an innovative and promising research field. This paper gives a review of fault diagnosis and prognostic based on deep learning. First of all, a brief introduction to deep learning architecture and the framework of fault diagnosis based on deep learning is described. Second, tracking describes the latest progress of fault diagnosis and prognostic based on deep learning in chronological order. In this section, the deep learning methods used in fault diagnosis and prognostic are discussed, including Deep Neural Network (DNN), Deep Belief Network (DBN) and Convolutional Neural Network (CNN). Then the engineering application fields are summarized, such as mechanical equipment diagnosis, electrical equipment diagnosis, etc. Finally, this paper indicates the potential future research issues in this field.
Escitalopram for the treatment of GAD: efficacy across different subgroups and outcomes.

BACKGROUND Generalized anxiety disorder (GAD) is characterized by anxiety, and also frequently associated with depressive symptoms. Benzodiazepines have commonly been used in the treatment of GAD, but are not effective antidepressant agents. In this study, we determined whether the selective serotonin reuptake inhibitor escitalopram, was effective across different subgroups and outcomes (anxious symptoms, depressive symptoms, and quality of life). METHODS Three randomized, placebo controlled studies of escitalopram in GAD have employed a similar design, allowing for pooling of the data. The primary efficacy measure was the Hamilton Anxiety Scale (HAMA). General linear models were used to determine the efficacy of escitalopram across different subgroups and outcomes. RESULTS Escitalopram was efficacious for GAD on a range of measures of both anxiety and depression, and improved the associated impairment in quality of life. There was no significant interaction of effects on the HAMA with demographic or clinical variables. Furthermore, escitalopram was efficacious on both primary and secondary scales in the subgroup of subjects with above-median severity of depressive symptoms at baseline (HAMD-17 > 12). CONCLUSIONS Escitalopram reduces anxiety and depressive symptoms in GAD, and improves quality of life. It is equally effective in GAD patients, with an above-median level of depressive symptoms. Further research is needed to determine whether these results can be extrapolated to GAD patients with comorbid major depression.
The Low Barrier Hydrogen Bond in Enzymatic Catalysis*

The proposal that low barrier (i.e. short, very strong) hydrogen bonds (LBHBs) play a role in enzymatic catalysis was first put forth in 1993 and 1994 (1–4). The proposal was accepted by some but rejected by others (5–8). Initial rejection on theoretical grounds has been followed by increasing experimental support, and recent improvements in theory have been able to account for the experimental observations of LBHBs in enzymes (9–15). In this minireview we will explain the original proposal, summarize the experimental data from the past few years, and argue that LBHBs do play important roles in enzymatic reactions.
A method of scaling bilateral control system with time delay in terms of modal space

This paper proposes a method of scaling bilateral control in the presence of time delay in terms of modal space. The bilateral control is characterized by a remote control, which return force information to the local site. Also, the bilateral control enable us to achieve dexterous tasks such as microsurgery by scaling the force/position response freely. However, bilateral control system has a problem, which is time delay, because interference between position and force control occurs and it degrades the performance and stability of the control system. In the time-delayed bilateral control, the force/position response conflict with each other, so it has been impossible to scale the force/position response separately. Hence, in this paper the control goals in bilateral control system under time delay is set to decouple force/position control. Moreover, the control goals enable us to scale force/position response in bilateral control system. The effectiveness of the proposed method is validated experimentally.
The effect of priming with interferon on interferon production by two lines of L cells.

Previous studies showed that several lines of cells of the same type differed greatly in the amounts of interferon produced when stimulated by the same inducer (Cantell & Paucker, 1963; Lockart, 1965). In our laboratory, one line of L cells, designated LTS, produced relatively small amounts of interferon when induced with either Newcastle disease virus (NDV) or the complex of polyriboinosinic and polyribocytidylic acids (poly IC); another line of L cells, designated Lpa, produced significantly larger amounts of interferon when exposed to either of these inducers. It appears, therefore, that LTS cells have less interferon-producing potential than have Lpa cells. We showed recently that cells were sensitized by incubation with interferon so that induction by an otherwise non-inducing virus resulted in greater yields of interferon (Stewart, Gosser & Lockart, 1971). Also, since interferon was made earlier and in response to subinducing concentrations of poly IC, we proposed that pretreatment with interferon somehow altered the induction process.
Ratio of platelet count/spleen diameter predicted the presence of esophageal varices in patients with schistosomiasis liver cirrhosis

Aim To examine the platelet count (PC)/spleen diameter (SD) ratio in predicting the presence of esophageal varices (EV) in patients with schistosomiasis liver cirrhosis. Materials and methods A total of 95 consecutive patients with EV induced by schistosomiasis liver cirrhosis were enrolled in this trial. A total of 141 schistosomiasis liver cirrhosis patients without EV were enrolled as controls. All patients were diagnosed by endoscopy. Demographic, laboratory, and Doppler ultrasound parameters were collected and analyzed. Binary logistic regression analysis was carried out to identify independent risk factors associated with EV occurrence. Receiver operating curves were generated to obtain the PC/SD ratio cutoff values for the optimal sensitivity and specificity with respect to EV. Results The accuracy was increased in diagnosing for EV using the ratio of PC/SD compared with the SD alone [area under the curve: 0.891 95% confidence interval (CI): 0.844–0.928 vs. 0.764 95% CI: 0.705–0.817; P<0.01]. The optimal cutoff value was 1004, with a 77.1% (95% CI: 67.9–84.8%) positive-predictive value and an 89.3% (95% CI: 82.7–94.0%) negative-predictive value. Using a cutoff of 1004, it was determined that 117/141 (83.0%) patients without EV could avoid undergoing unnecessary endoscopy, whereas 14/95 (14.7%) patients with EV would be misdiagnosed. In contrast, when the ratio was set at 909, the positive-predictive and negative-predictive values were 79.5% (95% CI: 69.5–87.4%) and 83.1% (95% CI: 76.1–88.8%), respectively. A ratio of 909 would accurately predict the absence of EV in 123/141 (87.2%) patients; however, 24/95 (25.3%) patients with EV would miss the necessary screening endoscopy. Conclusion The ratio of PC/SD was a useful marker in predicting the presence of EV in patients with schistosomiasis liver cirrhosis.
Modeling of a sampling system based on Sigma-Delta ADC for data acquisition in metrology

This paper describes the use of modeling to improve the accuracy of a sampling system built around a Sigma-Delta analog-to-digital converter. The parameters of the model were established using waveforms from a programmable Josephson array. The validation results have shown that the achievable accuracy is within 8 μV/V for signals in the frequency range up to 1.3 kHz at equivalent sampling rates below 32 kHz.
One for all and all for one: the energetic benefits of huddling in endotherms

Huddling can be defined as “an active and close aggregation of animals”. It is a cooperative group behaviour, permitting individuals involved in social thermoregulation to minimize heat loss and thereby lower their energy expenditure, and possibly allowing them to reallocate the saved energy to other functions such as growth or reproduction. Huddling is especially important in the case of animals faced with high heat loss due to a high surface‐to‐volume ratio, poor insulation, or living in cold environments. Although numerous experimental studies have focused on the huddling behaviour of a wide range of species, to our knowledge, this is the first attempt to review the various implications of this widely used behavioural strategy.
An evidence-based guideline for polycystic ovary syndrome.

As nurses form the largest health profession and provide health care across the lifespan (ANF 2011) it is therefore vital they have an increased awareness of Polycystic Ovary Syndrome (PCOS). In particular, nurses working in the areas of general practice, diabetes education, women's health, community health, mental health, Indigenous health and rural and remote health need to be aware that PCOS is a very common, chronic condition that affects up to one in five women of reproductive age.
A Polynomial-time Interior-point Algorithm for Convex Quadratic Semidefinite Optimization

In this paper we propose a primal-dual interior-point algorithm for convex quadratic semidefinite optimization problem. The search direction of algorithm is defined in terms of a matrix function and the iteration is generated by full-Newton step. Furthermore, we derive the iteration bound for the algorithm with small-update method, namely, O( $\sqrt{n}$ log $\frac{n}{\varepsilon}$ ), which is best-known bound so far.
Improved Human Embryonic Stem Cell Embryoid Body Homogeneity and Cardiomyocyte Differentiation from a Novel V‐96 Plate Aggregation System Highlights Interline Variability

Although all human ESC (hESC) lines have similar morphology, express key pluripotency markers, and can differentiate toward primitive germ layers in vitro, the lineage‐specific developmental potential may vary between individual lines. In the current study, four hESC lines were cultured in the same feeder‐free conditions to provide a standardized platform for interline analysis. A high‐throughput, forced‐aggregation system involving centrifugation of defined numbers of hESCs in V‐96 plates (V‐96FA) was developed to examine formation, growth, and subsequent cardiomyocyte differentiation from >22,000 EBs. Homogeneity of EBs formed by V‐96FA in mouse embryo fibroblast‐conditioned medium was significantly improved compared with formation in mass culture (p < .02; Levene's test). V‐96FA EB formation was successful in all four lines, although significant differences in EB growth were observed during the first 6 days of differentiation (p = .044 to .001; one‐way analysis of variance [ANOVA]). Cardiomyocyte differentiation potential also varied; 9.5% ± 0.9%, 6.6% ± 2.4%, 5.2% ± 3.1%, and 1.6% ± 1.0% beating EBs were identified for HUES‐7, NOTT2, NOTT1, and BG01, respectively (p = .008; one‐way ANOVA). Formation of HUES‐7 V‐96FA EBs in defined medium containing activin A and basic fibroblast growth factor resulted in 23.6% ± 3.6% beating EBs, representing a 13.1‐fold increase relative to mass culture (1.8% ± 0.7%), consistent with an observed 14.8‐fold increase in MYH6 (αMHC) expression by real‐time polymerase chain reaction. In contrast, no beating areas were derived from NOTT1‐EBs and BG01‐EBs formed in defined medium. Thus, the V‐96FA system highlighted interline variability in EB growth and cardiomyocyte differentiation but, under the test conditions described, identified HUES‐7 as a line that can respond to cardiomyogenic stimulation.
Soft-switching interleaved boost converter with high voltage gain

In this paper a soft-switching interleaved boost converter with high voltage gain is presented. The high voltage gain converter is far suitable for applications where a high step-up voltage is required, as in some renewable energy systems, which use, for example, photovoltaic panels and/or fuel cells. Besides, in order to guarantee small switching losses and, consequently, a high efficiency, a non- dissipative soft-switching cell with auxiliary commutation circuit is used. Thus, a large step-up voltage, low switching stress, small switching losses, and high efficiency are expected from this topology. In order to verify its effectiveness, experimental waveforms from the high voltage gain converter operating with hard-switching and soft-switching are compared. Also, waveforms from the soft-switching cell are presented and analyzed. Theoretical analysis, operation principle and topology details are also presented and studied.
Effect of a New Somatostatin Analogue on Pancreatic Function in Healthy Volunteers

We studied the effect of four graded doses of SMS 201-995, a synthetic octapeptide somatostatin analogue (27, 80, 240, and 720 ng/kg/h) on the basal and secretin-plus-cerulein-stimulated exocrine pancreatic function and pancreatic polypeptide (PP) release in five healthy volunteers. Duodenal fluid secretion and bicarbonate output under basal and stimulated conditions were not significantly affected by any dose of SMS. The basal and stimulated enzyme secretion were decreased in a non-dose-dependent manner by all SMS doses used in the study and showed a 75% inhibition of the secretin-plus-cerulein-stimulated trypsin and amylase output. The cerulein-stimulated PP release was significantly suppressed by all four SMS doses. SMS appears to be a strong inhibitor of pancreatic enzyme secretion, at the same time affecting the PP release.
Reading, Clumsiness, and the Deaf Child

The experiments reported here were undertaken to investigate the possibility that clumsiness, a possible secondary handicap of deafness, may cause an unsuspected retardation in reading ability in the deaf, even those without overt vestibular or neural damage.The tests of clumsiness that were used failed to differentiate between deaf and hearing children, and while the usual relationship between reading and clumsiness was confirmed in the hearing population, no such relationship was found for the deaf.Earlier research suggesting that the deaf may be clumsy was criticised, and the failure to link the degree of clumsiness to reading ability was interpreted in terms of research showing that reading age in the deaf means something quite different from reading age in the hearing.
Longitudinal Analysis of Vascular Function and Biomarkers of Metabolic Bone Disorders before and after Renal Transplantation

Background/Aims: The role of chronic kidney disease-mineral bone disorder (CKD-MBD) reversibility in the amelioration of vascular function and in the reduction of the risk for cardiovascular events after renal transplantation is still unknown. Methods: We investigated the longitudinal relationship between the main biomarkers of CKD-MBD and the evolution of vascular function [flow-mediated dilatation (FMD)] after transplantation in a series of 161 patients with kidney failure maintained on chronic dialysis (5D-CKD). Results: Before transplantation, FMD in patients was markedly lower (–40%, p < 0.001) than in well-matched healthy subjects and increased by 27% after transplantation (p = 0.001). Fibroblast growth factor 23 (FGF23), 25-hydroxy-vitamin D (25OHVD) and serum phosphate (p < 0.01) were independently associated with simultaneous changes in FMD. Changes in classical risk factors and in risk factors related to CKD like the glomerular filtration rate, serum albumin, C-reactive protein and insulin resistance failed to independently explain the variability in FMD changes after transplantation. Conclusion: Endothelium-dependent vasodilatation improves after kidney transplantation, which is parallel to the dramatic fall in FGF23, the reduction in serum phosphorus and the increase in 25OHVD levels. If these associations are causal, a part of decline in cardiovascular risk after transplantation is related to partial resolution of CKD-MBD.
Methyloferula stellata gen. nov., sp. nov., an acidophilic, obligately methanotrophic bacterium that possesses only a soluble methane monooxygenase.

Two strains of aerobic methanotrophic bacteria, AR4(T) and SOP9, were isolated from acidic (pH 3.8-4.0) Sphagnum peat bogs in Russia. Another phenotypically similar isolate, strain LAY, was obtained from an acidic (pH 4.0) forest soil in Germany. Cells of these strains were Gram-negative, non-pigmented, non-motile, thin rods that multiplied by irregular cell division and formed rosettes or amorphous cell conglomerates. Similar to Methylocella species, strains AR4(T), SOP9 and LAY possessed only a soluble form of methane monooxygenase (sMMO) and lacked intracytoplasmic membranes. Growth occurred only on methane and methanol; the latter was the preferred growth substrate. mRNA transcripts of sMMO were detectable in cells when either methane or both methane and methanol were available. Carbon was assimilated via the serine and ribulose-bisphosphate (RuBP) pathways; nitrogen was fixed via an oxygen-sensitive nitrogenase. Strains AR4(T), SOP9 and LAY were moderately acidophilic, mesophilic organisms capable of growth between pH 3.5 and 7.2 (optimum pH 4.8-5.2) and at 4-33 °C (optimum 20-23 °C). The major cellular fatty acid was 18 : 1ω7c and the quinone was Q-10. The DNA G+C content was 55.6-57.5 mol%. The isolates belonged to the family Beijerinckiaceae of the class Alphaproteobacteria and were most closely related to the sMMO-possessing methanotrophs of the genus Methylocella (96.4-97.0 % 16S rRNA gene sequence similarity), particulate MMO (pMMO)-possessing methanotrophs of the genus Methylocapsa (96.1-97.0 %), facultative methylotrophs of the genus Methylovirgula (96.1-96.3 %) and non-methanotrophic organotrophs of the genus Beijerinckia (96.5-97.0 %). Phenotypically, strains AR4(T), SOP9 and LAY were most similar to Methylocella species, but differed from members of this genus by cell morphology, greater tolerance of low pH, detectable activities of RuBP pathway enzymes and inability to grow on multicarbon compounds. Therefore, we propose a novel genus and species, Methyloferula stellata gen. nov., sp. nov., to accommodate strains AR4(T), SOP9 and LAY. Strain AR4(T) ( = DSM 22108(T) = LMG 25277(T) = VKM B-2543(T)) is the type strain of Methyloferula stellata.
An engineering design of a 2MW direct-drive permanent-magnet wind-power generation system

With rapid development of the power semiconductor devices, direct-drive permanent magnet synchronous generator (PMSG) has shown the significant advantages for its high efficiency, reliability, and becomes an attractive choice for variable-speed wind power generation. MW class PMSG system with larger capacity, higher power density is an important trend. This paper describes the engineering design of the domestic first 2MW direct-drive PMSG system, including optimal machine design, converter topology choosing and its control. The generator injects the power to the grid through two fully controlled back-to-back PWM converters that are parallel connected as master-slave structure. A load current sharing control strategy is presented for the parallel connection. Some experimental results are given to illustrate the performance of the actual system.
Neuroelectrostimulation in treatment of hyposalivation and xerostomia in Sjögren's syndrome: a salivary pacemaker.

Xerostomia is the symptom of oral dryness resulting most frequently, but not exclusively, from salivary gland hypo-function. Xerostomia is a common problem. Its prevalence in the general population has been estimated to be 10%–29%, women being more commonly affected than men1. Although more likely in middle to late life (perhaps reflecting the anticholinergic action of many drugs), xerostomia can affect young adults, but rarely children2,3. Xerostomia often arises as an adverse effect of drug therapy and can be a feature of psychological upset, cholinergic dys-function, radiotherapy to the head and neck, or disease of the salivary glands1. Patients with…
OSBP-Related Proteins: Liganding by Glycerophospholipids Opens New Insight into Their Function

Oxysterol-binding protein (OSBP) and its homologs designated OSBP-related (ORP) or OSBP-like (OSBPL) proteins constitute a conserved family of lipid binding/transfer proteins (LTP) in eukaryotes. The mechanisms of ORP function have remained incompletely understood, but they have been implicated as intracellular sterol sensors or transporters. A number of studies have provided evidence for the roles of ORPs at membrane contact sites (MCS), where endoplasmic reticulum is closely apposed with other organelle limiting membranes. ORPs are postulated to either transport sterols over MCSs or control the activity of enzymatic effectors or assembly of protein complexes with functions in signaling and lipid metabolism. Studies of yeast Saccharomyces cerevisiae ORPs Osh4p, Osh3p, Osh6p and Osh7p have revealed that ORPs do not exclusively bind sterols within their OSBP-related ligand-binding domain (ORD): The Osh4p ORD accommodates either sterols or phosphatidylinositol-4-phosphate (PI4P), and the Osh3p ORD was shown to specifically bind PI4P, the binding cavity being too narrow for a sterol to fit in. Most recently, Osh6p and Osh7p were demonstrated to show specific affinity for phosphatidylserine (PS), and to play a role in the intracellular transport of this glycerophospholipid; Additionally, two mammalian ORPs were shown to bind PS. Thus, the term frequently used for ORPs/OSBPLs, oxysterol-binding proteins, is a misnomer. While a number of ORPs bind oxysterols or cholesterol, other family members appear to interact with phospholipid ligands to regulate lipid fluxes, organelle lipid compositions and cell signaling. As a conclusion, ORPs are LTPs with a wide ligand spectrum and marked functional heterogeneity.
Stress, Gender and Motherhood (II)

s: 1st World Congress on Women’s Mental Health, Berlin, Germany, March 27–31, 2001, (2001) Arch Women’s Mental Health 3/4(Suppl. 2). Francis, D.D. , Diorio, J., Liu, D. and Meaney, M.J. (1999) “Non-genomic transmission across generations of maternal behaviour and stress responses”, Science 286, 1155–1158. McCormick, C.M. , Linkroum, W. , Sallinen, B.J. and Miller, N.W. (2002) “Peripheral and central sex steroids have differential effects on the HPA axis of male and female rats”, Stress 5, 235–247. Pedersen, C.A. and Boccia, M.L. (2002) “Oxytocin links mothering received, mothering bestowed and adult stress responses”, Stress 5, 259–267. Torner, L. and Neumann, I.D. (2002) “The brain prolactin system: involvement in stress response adaptations in lactation”, Stress 5, 249–257. Turner, R.A. , Altemus, M. , Yip, D.N. , Kupferman, E. , Fletcher, D. , Bostron, A. , Lyons, D.M. and Amico, J.A. (2000) “Effects of emotion on oxytocin, prolactin and ACTH in women”, Stress 5, 269–276. I.D. NEUMANN 234