Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of individual reminiscence therapy for older women living alone.

BACKGROUND The loss of cognitive function and memory interrupts the independent activities of daily living of older women, and it eventually causes role loss, increased dependence, declining self-esteem and low quality of life. AIM To examine the effects of the individual reminiscence therapy on memory self-efficacy, memory practice, Mini Mental State Examination and quality of life for older Korean women living alone. METHODS A quasi-experimental pre-test-post-test control group design was employed. Seventy-eight older women aged 65 and older who were living alone in Seoul and Gyeong-gi-do, Korea, was recruited through convenient sampling. Individual reminiscence therapy was applied for 1 h/week in the experimental group (40 subjects) for 4 weeks. A study questionnaire was designed to measure general characteristics, memory self-efficacy, memory practice (immediate, delayed), Mini Mental State Examination (MMSE) and quality of life. RESULTS There were significant differences in the effects of individual reminiscence therapy on memory self-efficacy, memory practice (immediate, delayed), and quality of life between experimental and control group. CONCLUSION Individual reminiscence therapy was an effective intervention for improving memory self-efficacy, memory practice (immediate, delayed), cognitive function and quality of life of older Korean women living alone. IMPLICATIONS FOR NURSING AND HEALTH POLICY Individual reminiscence therapy can be utilized as a nursing intervention for improving memory, cognition and quality of life of older women in the nursing practice. Health policy needs to give attention to health issues of older women living alone. Individual reminiscence therapy can be utilized as a nursing intervention for improving memory, cognition and the quality of life of older women. Health policy needs to give attention to health issues of older women living alone.
Co-construction de la croyance dans le récit / drame interactif

Cet article traite de la co-construction de la croyance mise en jeu par le recit interactif, dans lequel l'utilisateur exerce une influence sur le cours de l'histoire. Les questions de repartition des pouvoirs dans ce type d'ecriture et de lecture seront discutees en detail, selon le type d'œuvre envisagee.
Differential Regulation of Two Forms of Gonadotropin-Releasing Hormone Messenger Ribonucleic Acid in Human Granulosa-Luteal Cells* * This work was supported by grants from the Medical Research Council of Canada.

Until recently, the primate brain was thought to contain only one form of GnRH known as mammalian GnRH (GnRH-I). The recent cloning of a second form of GnRH (GnRH-II) with characteristics of chicken GnRH-II in the primate brain has prompted a reevaluation of the role of GnRH in reproductive functions. In the present study, we investigated the hormonal regulation of GnRH-II messenger RNA (mRNA) and its functional role in the human granulosa-luteal cells (hGLCs), and we provided novel evidence for differential hormonal regulation of GnRH-II vs. GnRH-I mRNA expression. Human GLCs were treated with various concentrations of GnRH-II, GnRH-II agonist (GnRH-II-a), or GnRH-I agonist (GnRH-I-a; leuprolide) in the absence or presence of FSH or human CG (hCG). The expression levels of GnRH-II, GnRH-I, and GnRH receptor (GnRHR) mRNA were investigated using semiquantitative or competitive RT-PCR. A significant decrease in GnRH-II and GnRHR mRNA levels was observed in cells treated with GnRH-II or GnRH-II-a. In contras.
A dynamic model for nitrogen-stressed lettuce.

A previously developed dynamic lettuce model, designed to predict growth and nitrate content under the normal range of glasshouse environmental conditions, has been extended to cover high nitrogen-stress situations. Under severe shortage of nitrogen, lettuce has been observed to grow at a very slow rate, as well as to have abnormally low water content, low reduced-nitrogen content and negligible nitrate content. The new model mimics these observations by adding to the original model a storage compartment for 'excess' carbon. The resulting model has three compartments: (1) 'vacuole', where the soluble non-structural material is stored, and the nitrate : carbon ratio may vary as needed to maintain a constant osmotic potential; (2) 'structure', a metabolically active compartment with fixed chemical composition; and (3) 'excess-carbon', which serves as a long-term storage of 'waterless' carbohydrates. Simulations with the model illustrate its ability to predict the effect of light, temperature and nitrogen in the nutrient solution on the long-term growth and composition of lettuce. They also illustrate the effects of plant size, and the associated relative growth rate, on the characteristic times of transient responses resulting from step changes in the environment.
EMC Design in Signal-Generating Circuit of Electromagnetic Position System

According to the theory of electromagnetic position system, a sine signal-generating circuit is designed. In the design of PCB, RF emission of IC and EMI of PCB has been analyzed. The EMC rules of component choice, component placement, trace wiring and grounding is presented. Some EMC simulated results of the circuit by HyperLynx software is given in the end.
The Antibiotic Polymyxin B Modulates P2X7 Receptor Function1

The natural peptide polymyxin B (PMB) is a well-known and potent antibiotic that binds and neutralizes bacterial endotoxin (LPS), thus preventing its noxious effects among LPS-mediated endotoxin shock in animal models. We have investigated the effect of PMB on responses mediated by the P2X7R in HEK293 and K562 cells transfected with P2X7 cDNA and in mouse and human macrophages. In addition, in view of the potential exploitation of P2X7-directed agonists in antitumor therapy, we also investigated the effect of PMB in B lymphocytes from patients affected by chronic lymphocytic leukemia. PMB, at an optimal concentration dependent on the given cell type, greatly potentiated the effect of nucleotide-mediated P2X7 stimulation. In particular, ATP-mediated Ca2+ influx, plasma membrane permeabilization, and cytotoxicity were enhanced to an extent that, in the presence of PMB, cells were killed by otherwise ineffective nucleotide concentrations. The synergistic effect due to the combined application of ATP and PMB was prevented by incubation with the irreversible P2X blocker oxidized ATP (oATP), but not with the reversible antagonist 1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-l-tyrosyl)-4-phenilpiperazine (KN-62). Cells lacking P2X7 were fully insensitive to the combined stimulation with PMB and ATP. Furthermore, PMB at the concentrations used had no untoward effects on cell viability. These results point to PMB as a useful tool for the modulation of P2X7R function and suggest that care should be used in the evaluation of ATP-stimulated immune cell responses in the presence of PMB as they may not solely be affected by removal of contaminating LPS.
Cortical activation patterns during voluntary blinks and voluntary saccades

Objective: To investigate the activation of frontal, parietal, and occipital areas in normal volunteers during voluntary blinks and during voluntary saccades using functional MRI (fMRI). Background: A previous fMRI study revealed the activation of the precentral and posterior middle frontal gyrus (“frontal eye field” [FEF]), the medial part of the superior frontal gyrus (“supplementary eye field” [SEF]), and the visual cortex. The parietal cortex was not included in this study. Frontal and occipital cortical areas involved in voluntary blinking have not been shown previously using fMRI. Methods: A 1.5-T standard clinical scanner was used for both anatomic and functional studies in 12 observers. To conduct data analyses the authors used voxel-by-voxel cross-correlation. Results: Voluntary blinks led to the activation (p < 0.05) of the FEF, the SEF, the posterior parietal cortex (“parietal eye field” [PEF]), and the visual cortex. Voluntary blinking produced activity in the same cerebral structures as voluntary saccades. However, the number of activated voxels was smaller during voluntary blinking than during voluntary saccades in the visual cortex and in the FEF (p < 0.01). In contrast, the extent of activation was significantly higher (p < 0.003) in the SEF and in the PEF during voluntary blinking. Conclusions: Voluntary blinks and saccades are associated with similar loci of activation patterns; however, the quantitative distribution of activation suggests that the middle part of the frontal gyrus and posterior parietal cortex are of special significance for voluntary blinks. The results argue for the importance of considering quantitative distributional properties of parallel cortical activities associated with saccades and blinks.
Arylglycerol glucosides from Dracocephalum forrestii

Three new arylglycerol glucosides, threo-guaiacylglycerol 3-O-(6-O-p-hydroxybenzoyl)-β-D-glucopyranoside (1), threo-guaiacylglycerol 3-O-[6-O-(E)-p-coumaroyl]-β-D-glucopyranoside (2) and threo-guaiacylglycerol 3-O-[6-O-(Z)-p-coumaroyl]-β-D-glucopyranoside (3), together with seven known compounds were isolated from the whole plants of Dracocephalum forrestii and their structures were determined on the basis of spectroscopic evidences.
Gene Dosage Balance in Cellular Pathways

THE gene dosage balance hypothesis (GDBH) proposes, in a narrow sense, that stoichiometric imbalances in macromolecular complexes can be a source of dominant phenotypes. Gene dosage balance in such complexes is required as a “here and now” condition, as a partial aneuploid carrying a deletion or
Further Light on Carbon Isotopes and Hopewell Agriculture

The 13C/12C ratio in human collagen was determined for 19 individuals from Hopewell sites in Wisconsin, Illinois, and Ohio and compared with 27 new measurements from individuals of Archaic, Mississippian, and Late Woodland affiliation. Additional measurements were made of elements in the food chain and on experimental animals fed on a diet of known composition containing maize. The similarity of the Hopewell measurements to those of nonmaize diets indicates that corn was of little importance in the Hopewell diet for those populations tested.
Performance Evaluation of MAC Layer Protocols for Ad Hoc WLAN

Ad hoc wireless networks provide infrastructure-free communication, an efficient MAC protocol through which mobile stations can share a common broadcast channel is essential. Present medium access mechanism used are Carrier Sense Multiple Access with Collision Avoidance (CSMA/CA), multiple access with collision avoidance (MACA) and CSMA/CA with RTS/CTS. These protocols are designed to reduce the collision probability between multiple stations accessing a medium. CSMA/CA with RTS/CTS and MACA use RTS/CTS exchange mechanism to reserve the channel. In this paper, First theoretical model of WLAN is developed and the maximum possible throughput is calculated. In later part of the paper, for the verification of theoretical mode, simulation environment is developed and detailed simulation is performed using GloMoSim simulator. Finally theoretical and simulation result are compared, which shows the variation of throughput with the variation of packet arrival rate and variation of average end to end delay with throughput.
Shaping mitochondria: The complex posttranslational regulation of the mitochondrial fission protein DRP1

Mitochondria are essential and dynamic cellular organelles differing in size, subcellular distribution, and internal structure. These aspects of mitochondrial morphology are intimately controlled by a growing number of mitochondrial morphology shaping proteins. The past decade has revealed remarkable and often unexpected new insights into the molecular regulation and physiological impact of mitochondrial morphology maintenance. Obviously, proper mitochondrial dynamics, resulting from a tightly regulated equilibrium between opposing mitochondrial fusion and fission activities, is a prerequisite for normal organelle function. Consequently, a disturbance of these activities results in mitochondrial dysfunction and, thus, can lay the foundation for human disorders. Here we specifically focus on recent advances in our understanding of the regulation, activity, and function of dynamin‐related protein 1, the main factor for controlled mitochondrial fission. © 2008 IUBMB IUBMB Life, 60(7): 448–455, 2008
An evaluation of the Kessner Adequacy of Prenatal Care Index and a proposed Adequacy of Prenatal Care Utilization Index.

OBJECTIVES The assessment of the adequacy of prenatal care utilization is heavily shaped by the way in which utilization is measured. Although it is widely used, the current major index of utilization, the Kessner/Institute of Medicine Index, has not been subjected to systematic examination. This paper provides such an examination. METHODS Data from the 1980 National Natality Survey are used to disaggregate the components of the Kessner Index for detailed analysis. An alternative two-part index, the Adequacy of Prenatal Care Utilization Index, is proposed that combines independent assessments of the timing of prenatal care initiation and the frequency of visits received after initiation. RESULTS The Kessner Index is seriously flawed. It is heavily weighted toward timing of prenatal care initiation does not distinguish timing of initiation from poor subsequent utilization, inaccurately measures utilization for full- or post-term pregnancies, and lacks sufficient documentation for consistent computer programming. CONCLUSIONS The Adequacy of Prenatal Care Utilization Index offers a more accurate and comprehensive set of measures of prenatal care utilization than the Kessner Index.
Emerging Therapies Targeting Intra‐Organ Inflammation in Transplantation

Over the past several years, the field of transplantation has witnessed significant progress on several fronts; in particular, achievements have been made in devising novel immunosuppressive strategies. An under‐explored area that may hold great potential to improve transplantation outcomes is the design of novel strategies to apply specifically to organs to reduce intra‐graft inflammation. A growing body of evidence indicates a key role of intra‐graft inflammatory cascade in potently instigating the alloimmune response. Indeed, controlling the activation of innate immunity/inflammatory responses has been shown to be a promising strategy to increase the graft acceptance and survival. In this minireview, we provide an overview of emerging targeted strategies, which can be directly applied to grafts to down‐regulate intra‐graft inflammation prior to transplantation.
Control by A-Factor of a Metalloendopeptidase Gene Involved in Aerial Mycelium Formation in Streptomycesgriseus

ABSTRACT In Streptomycesgriseus, A-factor (2-isocapryloyl-3R-hydroxymethyl-γ-butyrolactone) switches on aerial mycelium formation and secondary metabolite biosynthesis. An A-factor-dependent transcriptional activator, AdpA, activates multiple genes required for morphological development and secondary metabolism in a programmed manner. A region upstream of a zinc-containing metalloendopeptidase gene (sgmA) was found among the DNA fragments that had been isolated as AdpA-binding sites. The primary product of sgmA consisted of N-terminal pre, N-terminal pro, mature, and C-terminal pro regions. sgmA was transcribed in an AdpA-dependent manner, and its transcription was markedly enhanced at the timing of aerial mycelium formation. AdpA bound two sites in the region upstream of the sgmA promoter; one was at about nucleotide position −60 (A site) with respect to the transcriptional start point of sgmA, and the other was at about position −260 (B site), as determined by DNase I footprinting. Transcriptional analysis with mutated promoters showed that the A site was essential for the switching on of sgmA transcription and that the B site was necessary for the marked enhancement of transcription at the timing of aerial mycelium formation. Disruption of the chromosomal sgmA gene resulted in a delay in aerial hypha formation by half a day. SgmA is therefore suggested to be associated with the programmed morphological development of Streptomyces, in which this peptidase, perhaps together with other hydrolytic enzymes, plays a role in the degradation of proteins in substrate hyphae for reuse in aerial hypha formation.
NeuroMonitor: a low-power, wireless, wearable EEG device with DRL-less AFE

Electroencephalography (EEG) is an effective tool to non-invasively capture brain responses. Traditional EEG analogue front end (AFE) requires a driven right leg (DRL) circuit that restricts the number of channels of the device. The authors are proposing a new `DRL-less' AFE design, and have developed a wearable EEG device (NeuroMonitor), which is small, low-power, wireless, and battery operated. The EEG device with two independent channels was fabricated on an 11.35 cm 2 PCB that contained a system-on-a-chip microcontroller, a low-noise instrument amplifier, a low-power Bluetooth module, a microSD, a microUSB, and a LiPo battery. The DRL circuit was eliminated by utilising the high CMRR instrument amplifier with differential inputs, and followed by a modified high-Q active Twin-T notch filter (( f c Notch = 60 Hz, -38 dB). The signal was conditioned with a band-pass filter composed of a two-stage 2nd-order Chebyshev-I Sallen-Key low-pass filter cascaded with a passive 2nd-order low-pass filter ( f c LP = 125 Hz) and a 1st-order passive high-pass filter ( f c HP = 0.5 Hz). Finally, the signal was amplified to achieve an overall gain of 55.84 dB, and digitised with a 16-bit delta-sigma ADC (256 sps). The prototype weighs 41.8 gm, and has been validated against a research-grade EEG system (Neuroscan).
Superpixels for Spatially Reinforced Bayesian Classification of Hyperspectral Images

This letter presents a novel superpixel-based approach to hyperspectral image analysis which exploits spatial context within spectrally similar contiguous pixels for robust hyperspectral classification. The proposed approach entails two key steps-first, as a preprocessing step, we compute groupings (superpixels) through graph-based segmentation, following which an object-level classification is undertaken using a decision fusion approach that merges per-pixel outcomes from an ensemble of “per-pixel” Bayesian classifiers. The proposed method provides a robust way to exploit spatial contextual information. Every pixel in a superpixel is classified using statistical Bayesian classification independently, and the decisions are merged to obtain a unique class label for each superpixel. Experimental results with hyperspectral imagery indicate that the proposed method consistently provides a robust classification framework, even when using very limited training data.
Does near‐roadway air pollution contribute to childhood obesity?

Exposure to man-made combustion products, including secondhand tobacco smoke, maternal smoking during pregnancy, and near-roadway air pollution (NRAP), have been associated with increased body mass index and obesity in children and have been shown to result in excess weight gain in animal models. Potential mechanisms include pro-inflammatory central nervous system effects of airborne particles on appetite control, resulting in increased caloric intake, or changes in basal metabolism due to effects on mitochondria and brown adipose tissue. Combustion-derived polyaromatic hydrocarbons have also been linked to altered lipid metabolism, epigenetic effects on PPARγ expression, particle-induced estrogenic effects, and alterations in the distribution of visceral fat. Emerging evidence that a broad spectrum of environmental chemicals have “obesogenic” properties and alter the metabolic profile of adipose tissue challenges the prevailing model that the childhood obesity epidemic is explained solely by increased caloric density of food and decreased physical activity. Research on environmental obesogens could identify novel targets for intervention and yield public health benefits, since NRAP and SHS exposure are both common in populations most at-risk for development of obesity.
The Prospect of Using Cyanobacterial Bicarbonate Transporters to Improve Leaf Photosynthesis in C3 Crop Plants[W]

The photosynthetic CO2-fixing enzyme Rubisco arose some 3.5 billion years ago, in an environment when CO2 was high and oxygen (O2) was low. Under these conditions, it was CO2 saturated and presumably performed well ([Badger et al., 1998][1]). However, since the advent of oxygenic photosynthesis, the
1-{2-(4-Chlorobenzyloxy)-2-[4-(morpholin-4-yl)phenyl]ethyl}-1H-benzimidazole propan-2-ol monosolvate

In the title compound, C26H26ClN3O2·C3H7OH, the benzimidazole ring system is essentially planar [maximum deviation = −0.018 (2) Å] and its mean plane is oriented with respect to the two benzene rings at dihedral angles of 4.51 (6) and 56.16 (6)°, and the dihedral angle between the two benzene rings is 59.11 (7)°. The morpholine ring displays a chair conformation. The propan-2-ol solvent molecule links with the benzimidazole ring via an O—H⋯N hydrogen bond. In the crystal, weak intermolecular C—H⋯O hydrogen bonds link the molecules into inversion dimers with an R 2 2(28) motif. π–π stacking occurs between the parallel chlorobenzene rings [centroid–centroid distance = 3.792 (1) Å]. Weak C—H⋯π interactions and short Cl⋯Cl [3.2037 (10) Å] contacts are also observed.
Software contributions to the reliability of systems of systems

Systems of great complexity that require high levels of reliability are increasingly foundational to national security as well as economic and social activities. Many of these systems are in fact systems of systems - an arrangement in which independent and separately useful systems are integrated into a larger functioning system to deliver unique capabilities. Systems of systems depend on the proper functioning of both the constituent systems and the coordination that software can provide to assure reliable accomplishment of a given mission. Software that not only provides the logic for much of the capability of the individual systems but - in bridging between constituent systems with data and control flows - it is may also be leveraged to coordinate and direct the assembled system of systems. This paper will address how software and systems engineering can be key to ensuring that an assembled system of systems accomplishes its mission.
Non-standard lattices and o-minimal groups

Abstract We describe a recent program from the study of definable groups in certain o-minimal structures. A central notion of this program is that of a (geometric) lattice. We propose a definition of a lattice in an arbitrary first-order structure. We then use it to describe, uniformly, various structure theorems for o-minimal groups, each time recovering a lattice that captures some significant invariant of the group at hand. The analysis first goes through a local level, where a pertinent notion of pregeometry and generic elements is each time introduced.