Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of the Techniques of the Microscopic Varicocelectomy and Inguinal Varicocelectomy

DOI: 10.4328/JCAM.790 Received: 24.09. 2011 Accepted: 05.10. 2011 Printed: 01.10. 2012 J Clin Anal Med 2012;3(4): 409-11 Corresponding Author: Necip Pirinççi, Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Maraş Caddesi 65100 Van, Türkiye. T. : +90 4322150474/6258 E-Mail: necippirincci@hotmail.com Özet Amaç: İki farklı varikoselektomi tekniğinin sonuçlarını karşılaştırmak. Gereç ve Yöntem: Temmuz 2005Şubat 2011 tarihleri arasında yaşları 15-39 ( 26,4 ± 6 ) olan klinik varikosel nedeniyle inguinal varikoselektomi veya subinguinal mikroskopik varikoselektomi yapılmış 84 varikoselli 68 hasta retrospektif olarak değerlendirildi. Her iki grubun komplikasyon oranları, preoperatif ve postoperatif sperm parametreleri, gebelik oranları değerlendirilip karşılaştırıldı. Bulgular: Subinguinal mikroskopik grupta operasyon süresi inguinal gruba göre anlamlı olarak uzundu. Subinguinal mikroskopik grupta hidroselektomi ve nüks varikosel görülmezken; inguinal grupta 3 olguda hidrosel, 5 olguda nüks varikosel saptandı. Aradaki fark anlamlıydı. Subinguinal mikroskopik grupta sperm sayı ve/veya hareketinde % 75 iyleşme, inguinal grupta ise % 64 iyleşme olup; bu değerler her iki grupta istatistiksel olarak anlamlı karşılaştırılabilir düzeydeydi. İlk yıldaki gebelik oranları subinguinal mikroskopik grupta % 29, inguinal grupta % 26 olup; her iki grup arasında gebelik oranları arasında anlamlı bir fark saptanmadı. Sonuç: Subinguinal mikroskopik varikoselektomi düşük komplikasyon ve daha yüksek başarı oranları ile inguinal varikoselektomiye göre daha iyi sonuçlar vermektedir.
Doris: An Adaptive Soft Real-Time Scheduler in Virtualized Environments

With the development of cloud computing and virtualization technologies, more and more soft real-time applications, such as Voice over Internet Protocol (VoIP) server and cloud gaming, are running in virtualized data centers. Though previous studies optimize CPU schedulers of hypervisors to support these applications in virtualized environments, there are some important challenges in designing an efficient CPU scheduler which is suitable for real-world clouds. On one hand, hypervisors do not know whether an application in a virtual machine (VM) has real-time requirements, so manually setting the scheduling parameters is a common case for CPU schedulers, which probably increases users’ burden, lacks flexibility, and causes misconfigurations. On the other hand, it has been reported that most of existing CPU schedulers designed for soft real-time applications have an obvious propensity to such applications which prevents them from being applied in practical multi-tenant cloud environments. In this paper, we design and implement an adaptive soft real-time scheduler based on Xen, named Doris, to address these challenges. It identifies the VMs running soft real-time applications (RT-VMs) and infers their scheduling parameters according to the communication behaviors of VMs adaptively. Then, it promotes the priorities of VCPUs of the RT-VMs temporarily according to I/O events and the inferred scheduling parameters of RT-VMs to support soft real-time applications adaptively while minimizing the impacts on non-real-time applications. Finally, considering the importance of privileged entities (such as Domain0 in Xen) in I/O processing, Doris sets their types and scheduling parameters dynamically, which enables the adaptive scheduling of them to guarantee the performance of soft real-time applications. Our evaluation shows Doris can support soft real-time applications adaptively and efficiently, and only introduces very slight overhead.
P wave dispersion in patients with premenstrual dysphoric disorder

1Department of Obstetrics and Gynecology, Faculty of Medicine, Firat University, Elazig, Turkey 2Department of Cardiovascular Surgery, Education and Research Hospital, Elazig, 23119, Turkey 3Department of Psychiatry, Faculty of Medicine, Firat University, Elazig, Turkey 4Department of Obstetrics and Gynecology, Faculty of Medicine, Kafkas University, Kars, Turkey 5Department of Cardiology, Faculty of Medicine, Firat University, Elazig, Turkey More Information
A COMPARISON BETWEEN THE MODERN AND THE LOWER BODY GOLF SWING TECHNIQUES– PILOT STUDY WITH IMPLICATIONS FOR LOWER BACK INJURY RISK

The purpose of this study was to compare the biomechanical characteristics of the lower body swing to modern swing techniques, with a focus on lower back injury risk. Fifteen male individuals free from lower back injury participated in this study. Nine participants utilized the modern swing (age = 48.0 ± 13.6 years; height = 176.8 ± 4.4 cm; mass = 82.1 ± 5.3 kg) while six utilized the lower body swing (age = 53.9 ±12.1 years; height = 182.9 ± 6.1 cm; mass = 92.5 ± 14.8 kg). Whole body kinematics were recorded with a ten-camera motion analysis system while individuals performed 5 shots with a driver for maximum distance. Continuous waveform and discrete point analysis was used to explore the differences between these two techniques. The lower body swing demonstrated favourable kinematics in the majority of variables related to lower back pain and lumbar load.
Frequency Of Elevated Troponin T In Patients Of Hronic Renal Failure Without Clinically Suspected Acute Myocardial Infarction.

BACKGROUND Cardiac Troponins are established markers of myocardial injury; however, they may be elevated in chronic renal failure (CRF) patients even in absence of acute myocardial infarction. The objective of the study was to determine the frequency of elevated Troponin T in patients of chronic renal failure without clinically suspected acute myocardial infarction. METHODS This cross-sectional study was conducted at Medical B Unit of Ayub Teaching Hospital, Abbottabad from 16th December 2013 to 16th June 2014. A sample of 117 patients of chronic renal failure was included in the study without any gender discrimination. The patients were defined as known chronic renal failure when renal failure was reported in their past medical history and by estimation of glomerular filtration rate (GFR). Those patients who had raised Troponin T due to any other reason like acute myocardial ischemia (chest pain, electrocardiographic changes and greater than 20% elevation in Troponin T from baseline), sepsis, heart failure and those who were receiving cardiotoxic chemotherapy were excluded. The subjects were enrolled by non-probability consecutive sampling. Results were analysed by SPSS 16.0. RESULTS Out of 117 participants, 72 (61.5%) were males and 45 (38.5%) were females. The mean age of the study participants was 52.08±14.21 years. Elevated Troponin T was found in 45 (38.5%) of the patients. There is statistically significant association between the stage of CRF and elevated levels of Troponin T. Statistically significant negative correlation (r=-0.213,p=0.021) was found between the Glomerular Filtration Rate and serum levels of Troponin T. CONCLUSIONS A high proportion of CRF patients have elevated Troponin T and the rise is significantly associated with the stage of chronic renal failure.
Time to colonoscopy, cancer probability, and precursor lesions in the Danish colorectal cancer screening program

Purpose The aim of this study was to investigate the effect of response time from the Fecal Immunochemical Test (FIT) based screening invitation to the conclusive screening Optical Colonoscopy (OC) on the risk of detecting colorectal cancer (CRC), advanced stage disease and precursor lesions. Patients and methods We used a cross-sectional study design and included all 62,554 screening participants registered in the Danish Colorectal Cancer Screening Database who tested FIT-positive between March 2014 and December 2016. The main exposure was response time, measured as the time from initial invitation to the conclusive OC. Our main outcomes were the probability of being diagnosed with CRC, advanced stage disease or precursor lesions. Results Of the 62,554 FIT-positive participants, 53,171 (85%) received an OC and were eligible for analysis (median age 63.7 years, 56% men). In this group, 3,639 cancers were registered, 2,890 of which were registered with a defined stage of disease (79%), and 1,042 (36%) of these were advanced stage (UICC III & IV). In addition, 17,732 high-risk and 10,605 low-risk adenomas were identified. Compared to participants receiving the conclusive examination within 30 days, those receiving the examination more than 90 days after initial invitation were 3.49 times more likely to be diagnosed with any CRC (OR 3.49 [95% CI, 3.13–3.89]) and 2.10 times more likely to have advanced stage disease (OR 2.10 [95% CI, 1.73–2.56]). Those waiting for the longest were also more likely to have one or more high-risk adenomas (OR 1.59 [95% CI, 1.50–1.68]). Conclusion Increased screening response time was associated with a higher probability of detecting high-risk adenomas, any stage CRC and advanced stage cancer. More research is needed to explain what causes these associations.
Medication safety in the perioperative setting: A comparison of methods for detecting medication errors and adverse medication events

The purpose of this study was to evaluate perioperative medication-related incidents (medication errors (MEs) and/or adverse medication events (AMEs)) identified by 2 different reporting methods (self-report and direct observation), and to compare the types and severity of incidents identified by each method. We compared perioperative medication-related incidents identified by direct observation in Nanji et al’s 2016 study[1] to those identified by self-report via a facilitated incident reporting system at the same 1046-bed tertiary care academic medical center during the same 8-month period. Incidents, including MEs and AMEs were classified by type and severity. In 277 operations involving 3671 medication administrations, 193 MEs and/or AMEs were observed (5.3% incident rate). While none of the observed incidents were self-reported, 10 separate medication-related incidents were self-reported from different (unobserved) operations that occurred during the same time period, which involved a total of 21,576 operations and approximately 280,488 medication administrations (0.004% self-reported incident rate). The distribution of incidents (ME, AME, or both) did not differ by direct observation versus self-report methodology. The types of MEs identified by direct observation differed from those identified by self-report (P = .005). Specifically, the most frequent types of MEs identified by direct observation were labeling errors (N = 37; 24.2%), wrong dose errors (N = 35; 22.9%) and errors of omission (N = 27; 17.6%). The most frequent types of MEs identified by self-report were wrong dose (N = 5; 50%) and wrong medication (N = 4; 40%). The severity of incidents identified by direct observation and self-report differed, with self-reported incidents having a higher average severity (P < .001). The procedure types associated with medication-related incidents did not differ by direct observation versus self-report methodology. Direct observation captured many more perioperative medication-related incidents than self-report. The ME types identified and their severity differed between the 2 methods, with a higher average incident severity in the self-reported data.
A Curative Perspective on Down Syndrome

: A curative perspective on Down syndrome is pointing out. Experimental work regarding chromosome correction and corrective action on genes and proteins is yielding positive results. They open the way to advances in dealing with aneuploidies and may end up markedly changing the life of the individuals affected with these conditions at the same time, several molecules are in the research pipeline of cognitive pharmacotherapy. The paper summarizes these advances and set them into perspective for the future of Down syndrome. Research on the effects of the amyloid cascade in the etiology of Alzheimer disease, which is more frequent in aging persons with Down syndrome, is also analyzed. Its potential for improving early diagnosis and paving the way for stabilizing the condition at least in the first stages is also discussed.
Survey of Approaches to Generate Realistic Synthetic Graphs

A graph is a ﬂexible data structure that can represent relationships between entities. As with other data analysis tasks, the use of realistic graphs is critical to obtaining valid research results. Using the actual ("real-world") graphs for research and new algorithm development is often di ﬃ cult due to the presence of sensitive information in the data or due to the scale of data. This results in practitioners developing algorithms and systems that employ synthetic graphs instead of real-world graphs. Generating realistic synthetic graphs that provide reliable statistical conﬁdence to algorithmic analysis and system evaluation involves addressing technical hurdles in a broad set of areas. This report surveys the state of the art in approaches to generate realistic graphs that are derived from ﬁtted graph models on real-world graphs.
An Expert System for Diagnosis of Sleep Disorder Using Fuzzy Rule-Based Classification Systems

Sleep disorder is an anomaly that could cause problems for someone’ sleeping pattern. Nowadays, it becomes an issue since people are getting busy with their own business and have no time to visit the doctors. Therefore, this research aims to develop a system used for diagnosis of sleep disorder using Fuzzy Rule-Based Classification System (FRBCS). FRBCS is a method based on the fuzzy set concepts. It consists of two steps: (i) constructing a model/knowledge involving rulebase and database, and (ii) prediction over new data. In this case, the knowledge is obtained from experts whereas in the prediction stage, we perform fuzzification, inference, and classification. Then, a platform implementing the method is built with a combination between PHP and the R programming language using the “Shiny” package. To validate the system that has been made, some experiments have been done using data from a psychiatric hospital in West Java, Indonesia. Accuracy of the result and computation time are 84.85% and 0.0133 seconds, respectively.
Reports in anaesthesia come of age!

1Consultant Anaesthetist, Department of Anaesthesia,Worcestershire Acute Hospitals NHS Trust, UK 2Clinical Fellow in Paediatric Anaesthesiology, Children’s Hospital of Philadelphia andUniversity of Pennsylvania, USA 3Consultant Anaesthetist, Department of Anaesthesia, 4 Consultant Anaesthetist, Department of Cardiothoracic Anaesthesia,WythenshaweHospital, Manchester University Hospitals NHS Foundation Trust, Manchester, UK
Investigation preoperative seroprevalence of hbsag, anti-hbs, anti-hcv, anti-hiv and vaccination level of patients undergoing dental surgical procedure under local anesthesia

Aim: Health care workers especially dentists are at risk due to the fact that they are in direct contact with the blood and body fluids. In the present study, it was aimed to determine the preoperative seropositivity of HBsAG, anti-HBs, anti-HCV, and anti-HIV in the patients undergoing dental surgical procedure under local anesthesia. Material and Methods: 1598 patients who were admitted to Department of Oral and Maxillofacial Surgery between 2017-2018 and underwent surgical intervention for various reasons were included. Demographic data and serum samples taken preoperatively from patients were retrospectively evaluated in terms of HBsAg, Anti-HBs, Anti-HCV and Anti-HIV seropositivity by using archive records. Furthermore, the vocational and educational status of the HBsAg (+) patients in addition their awareness about hepatitis were investigated. Results: Of the 1598 patients, 591 (37%) were males; 1007 (63%) were females. The total number of patients with HBV carriers was 73 (4.6%), the number of anti-HBs-positive patients was 828 (51.8%), and the number of anti-HCV-positive patients was 3 (0.19%). Anti-HIV positivity has been observed in none of the patients. When evaluated according to the age ranges, HBsAg was mostly detected positive in the age ranges of 21-30 and 30-40; when evaluated according to sex, HBsAg was detected higher in women. Conclusions: Knowing the prevalence of infectious diseases is highly important for both the prevention and early diagnosis of these diseases. Besides, knowing the seropositivity of these diseases before surgical interventions will facilitate for both oral and maxillofacial surgeons and other health care personnel to take necessary safety precautions against disease transmission. For this purpose, although it was observed in our study that the preoperative HBsAg, anti-HBs, anti-HCV and anti-HIV seroprevalence were not higher than those in the population were, all health care workers should be trained in occupational diseases, vaccinated and followed up at regular intervals.
Adverse drug reaction extraction on electronic health records written in Spanish

This work focuses on the automatic extraction of Adverse Drug Reactions (ADRs) in Electronic HealthRecords (EHRs). That is, extracting a response to a medicine which is noxious and unintended and whichoccurs at doses normally used. From Natural Language Processing (NLP) perspective, this wasapproached as a relation extraction task in which the drug is the causative agent of a disease, sign orsymptom, that is, the adverse reaction.ADR extraction from EHRs involves major challenges. First, ADRs are rare events. That is, relationsbetween drugs and diseases found in an EHR are seldom ADRs (are often unrelated or, instead, related astreatment). This implies the inference from samples with skewed class distribution. Second, EHRs arewritten by experts often under time pressure, employing both rich medical jargon together with colloquialexpressions (not always grammatical) and it is not infrequent to find misspells and both standard andnon-standard abbreviations. All this leads to a high lexical variability.We explored several ADR detection algorithms and representations to characterize the ADR candidates.In addition, we have assessed the tolerance of the ADR detection model to external noise such as theincorrect detection of implied medical entities implied in the ADR extraction, i.e. drugs and diseases. Westtled the first steps on ADR extraction in Spanish using a corpus of real EHRs.
Safety and comfort of levonorgestrel-releasing intrauterine device (Jaydess): Results of a Spanish population survey.

All healthy women aged 18-40 years old with regular menses requesting contraception were recruited. Participants who decided to use the LNG-IUS were included and they must previously have a complete clinic history and physical examination with an ultrasound scan to rule out any condition/pathology that would contraindicate the use of an intrauterine system. Women were excluded if they were known or suspected to be pregnant, were lactating, or had a vaginal delivery, Cesarean section, or abortion within 6 weeks before screening. Other exclusion criteria were: a history of ectopic pregnancy; distortion of the uterine cavity (due to broids), abnormal uterine bleeding of unknown origin; acute or history of recurrent pelvic in ammatory disease; or any lower genital tract infection not treated.
A cross-disciplinary approach to embedding: A pedagogy for developing academic literacies

Resulting from a major restructure of academic support at one Australian university, the lowering of English language entry requirements and the diversification of the Higher Education sector, there is substantial concern that the needs of students at this university are not adequately met. Existing research now recognizes the critical role that embedding academic literacies into the disciplines plays in addressing the demands of the tertiary environment. This paper reports on the expansion of the Unit Support Program (USP), an embedded, integrated and team taught initiative, from first to second and third years in three units across two disciplines. The focus is particularly on the nature of the collaborative process between discipline and academic language and literacy staff and considers the unique team teaching aspect of this cross-disciplinary approach to embedding as a model of best practice. It examines the methods of negotiating the shared teaching and learning space both in and out of the classroom, models collaborative practices, and identifies the associated benefits these provide to both students and academic staff.
Does prior antithrombotic therapy influence recurrence and bleeding risk in stroke patients with atrial fibrillation or atrial flutter?

Background Whilst antithrombotic therapy is recommended in people with atrial fibrillation, little is known about the survival benefits of antithrombotic treatment in those with both high ischaemic and bleeding risk scores. We aim to describe the distribution of these risk scores in those with a prior diagnosis of atrial fibrillation who have suffered stroke and to determine the net clinical benefit of antithrombotic treatment. Methods We used regional stroke register data in the UK. Patients with a prior diagnosis of atrial fibrillation and ischaemic or haemorrhagic stroke patients were selected and their ischaemic stroke risk score (CHA2DS2-VASc) and bleeding risk score (HEMORR2HAGES) scores retrospectively calculated. Logistic regression and Cox proportional hazards models were constructed to determine the association between antithrombotic therapy prior to stroke and in-hospital and long-term mortality. Results A total of 1928 stroke patients (mean age 81.3 years (standard deviation 8.5), 56.8% women) with prior atrial fibrillation were included. Of these, 1761 (91.3%) suffered ischaemic stroke. The most common phenotype (64%) was of those with both high CHA2DS2-VASc (≥2) and high HEMORR2HAGES score (≥4). In our fully adjusted model, patients on antithrombotic treatment with both high ischaemic and bleeding risk had a significant reduction in odds of 31% for in-hospital mortality (odds ratio 0.69 (95% confidence interval 0.48–1.00: p = 0.049)) and 17% relative risk reduction for long-term mortality (hazard ratio 0.83 (95% confidence interval 0.71–0.97: p = 0.02)). Conclusions Our study suggests that antithrombotic treatment has a prognostic benefit following incident stroke in those with both high ischaemic risk and high bleeding risk. This should be considered when choosing treatment options in this group of patients.
Optimizing neoadjuvant radiotherapy for resectable and borderline resectable pancreatic cancer using protons

Approximately 25% of patients diagnosed with pancreatic cancer present with non-metastatic resectable or borderline resectable disease. Unfortunately, the cure rate for these “curable” patients is only in the range of 20%. Local-regional failure rates may exceed 50% after margin-negative, node-negative pancreatectomy, but up to 80% of resections are associated with regional lymph node or margin positivity. While systemic drug therapy and chemotherapy may prevent or delay the appearance of distant metastases, it is unlikely to have a significant impact on local-regional disease control. Preoperative radiotherapy would represent a rational intervention to improve local-regional control. The barrier to preoperative radiotherapy is the concern that it could potentially complicate what is already a long and complicated operation. When the radiotherapy is delivered with X-rays (photons), the entire cylinder of the abdomen is irradiated; therefore, an operating surgeon may be reluctant to accept the associated risk of increased toxicity. When preoperative radiotherapy is delivered with protons, however, significant bowel and gastric tissue-sparing is achieved and clinical outcomes indicate that proton therapy does not increase the risk of operative complications nor extend the length of the procedure.