Miracle-dz/UniFAR-FTUs huggingface dataset:
Analyse numérique et expérimentale de la sustentation par vol battu. Application aux micro-drones.

A bas nombre de Reynolds, le concept de voilure battante est recemment apparu comme une alternative aux concepts conventionnels de voilure fixe et voilure tournante. Dans le cadre d'une application pratique (micro-drones ou MAVs), l'evaluation de l'adaptabilite d'un tel mode de sustentation requiert la comprehension fine des principaux mecanismes aerodynamiques mis en jeu et de leur impact sur les efforts resultants. Ces derniers se caracterisent par une instationnarite forte et des comportements complexes. Le travail realise s'articule autour de trois points. Dans un premier temps, l'etablissement d'une correlation precise entre comportement spatio-temporel des structures coherentes et effort resultant passe par la definition de methodes d'investigation adaptees a l'etude d'ecoulements bi et tridimensionnels resolus en temps. En ce sens, l'analyse repose d'une part sur une approche numerique DNS par maillage mobile, et d'autre part sur les approches experimentales TRPIV- 2D2C/3D3C conduisant a la mesure non-intrusive des efforts aerodynamiques par application du bilan de quantite de mouvement. Les difficultes associees a ces techniques novatrices sont ici mises en exergue. En second lieu, nous abordons deux types de configurations bidimensionnelles caracterisees par des cinematiques de battement respectivement symetriques et asymetriques. Nous nous limitons a l'etude du vol stationnaire ou sur place pour lequel les effets instationnaires sont preponderants vis- a-vis des effets quasi-stationnaires. D'abord, l'analyse detaillee d'un cas de reference permet d'affiner les resultats reportes dans la litterature. Ensuite, la confrontation systematique de cas asymetriques rev`ele l'occurrence de phenom`enes aerodynamiques particuliers contribuant favorablement a l'efficacite de l'aile. L'approximation bidimensionnelle occulte toutefois l'influence du tourbillon marginal ou du gradient transverse de vitesse incidente etabli le long de l'envergure d'une aile en revolution autour de son emplanture. L'une des specificites des configurations tridimensionnelles provient effectivement du caract`ere stabilisateur de certains mecanismes aerodynamiques. Ainsi, nous presentons les effets tridimensionnels et leur dependance vis-a-vis de l'allongement dans le cas de mouvements de battement en translation rectiligne et en rotation autour d'un axe vertical.
DEVELOPMENT OF IMMUNOASSAYS FOR THE IRON‐REGULATED PROTEINS FERREDOXIN AND FLAVODOXIN IN POLAR MICROALGAE 1

While the growth of Southern Ocean phytoplankton is often limited by iron availability, there are no comparable experiments on sea‐ice algae. Here we assess the use of ferredoxin and flavodoxin to investigate the iron nutritional status of sea‐ice algae and describe the development of a quantitative immunoassay for both proteins in marine diatoms. High‐affinity monoclonal antibodies toward both proteins were produced from Cylindrotheca closterium (Ehrenb.) J. M. Lewin et Reimann, and these were used to develop Western blots. Western blots run on whole protein extracts detected both proteins with little cross‐reactivity toward other proteins. The two proteins could be successfully quantitated when applied to gels at between 5 and 50 ng in a volume of 25 μL (0.2–2 μg · mL−1). Flavodoxin and ferrodoxin expression was examined in the Antarctic diatoms Entomoneis kjellmannii (Cleve) Poulin et Cardinal, Navicula directa (W. Sm.) Ralfs, Fragilariopsis curta (Van Heurck) Hust. , Pseudo‐nitzschia sp. , Porosira glacialis (Grunow) E. G. Jørg. , Fragilariopsis cylindrus (Grunow) Willi Krieg. , Fragilariopsis sublinearis (Van Heurck) Heiden et Kolbe, C. closterium, Nitzschia lecointei Van Heurck, and the dinoflagellate Polarella glacialis Montresor, Procaccini et Stoecker. Two Arctic isolates were also examined, Nitzschia frigida (Grunow) and Fragilariopsis oceanica (Cleve) Hasle. Significant heterogeneity of protein expression was observed despite all cultures being grown in iron‐replete f/2 medium. Only one species, F. cylindrus, displayed the expected expression of ferredoxin only in iron‐replete medium. Four were observed to produce both proteins under iron‐replete conditions. Ferredoxin was not detected at all in F. curta and Pseudo‐nitzschia sp. , but distinct flavodoxin bands were observed in both of these organisms. All species examined were observed to express either flavodoxin or ferredoxin or both of the proteins as determined by Western immunoblotting.
Organizational project management in Omsk region companies: current state and development constraints

Despite widespread concept of project management, companies in major regions of Russia are still at the initial level of project management maturity. The paper is aimed to determine the current state and dynamics of organizational project management in the companies of the Omsk region, identify problem areas, and seek directions for further development. The author interviewed managers and project management practitioners in 148 companies from a variety of industries in the Omsk region. The study compares the survey results received during two years (2015â€“2016). The findings indicate that within the majority of companies, the organizational project management is not fully adopted. The author has empirically tested that high-performers are more likely to appreciate the value of project management than low-performers. However, the only small proportion of companies demonstrates a high level of project management maturity. Moreover, no strong relationship has been found between matured project management processes in a company and its performance. The author revealed and ranged the main problems in the organizational project management development. These problems are concerned with a poor support of organizational enablers. The organizational project management development should be considered in the context of strategic governance and management. The findings contribute to the understanding of key processes, which constitute project capabilities in a company. The research results can be used for building a conceptual model and studying organizational project management dynamics in a region during a longer period.
Analysis of clinical interventions and the impact of pediatric pharmacists on medication error prevention in a teaching hospital.

OBJECTIVE Research has shown that the potential risk for medication errors within the pediatric inpatient population is about 3 times as high as for adults; however, there is limited information regarding the impact of a pediatric pharmacist's contribution to decreasing medication errors and adverse drug events (ADEs). The purpose of this study was to record and analyze all interventions during a 2-month time span in a pediatric teaching hospital to determine the benefit of having a pediatrics-trained clinical pharmacist on the floor. METHODS Pediatric pharmacists prospectively collected data for all interventions and medication errors made between July 1 and August 31, 2010. The pediatric hospital comprises 87 beds, and data were collected during the influx of new pediatric resident interns on the general pediatric ward and pediatric and neonatal intensive care units. RESULTS During the study period, 1315 interventions were recorded, which is an average of 21 interventions per day. Most interventions were made through order entry. Errors made up 24.5% of all interventions, with the most common cause of error being prescribing. Physicians with the least amount of training made the most errors. Of order pages scanned, 5.9% contained an error in the order; however, only 0.2% of all errors reached the patient. CONCLUSIONS This study highlighted the impact a pediatric pharmacist can make on prevention of ADEs and medication errors. Only 0.2% of all errors made during the study period reached the patient owing to interventions made by the pediatric pharmacists, which shows a vast improvement in patient safety.
Promoting Transportation Sustainability by Utilizing Available Roadway Capacity

Land use changes affect travel demand, resulting in the need to expand transportation infrastructure. Unfortunately, an inevitable consequence of urban sprawl, the spreading of a city to suburbs and outskirts, is the creation of auto-dependent development. Land use models forecast without considering underutilized roadways leading to urban sprawl. Any change in travel cost or detrimental growth pattern does not have any significant influence on future land use or location choice of future household and employment. This study addresses urban sprawl and available capacity utilization and combines those features with land use change model for planning more compact cities. This research conducted a rigorous step by step analysis to determine a better solution that results in more trips inside a case study community. Based on minimizing vehicle mileage traveled (VMT) and the number of congested links, a preferred scenario was identified that is one of the major contributions of this exploration. Hence, it is a preliminary initiative to promote transportation sustainability and build compact cities using current resources instead of the planning of future road network solely depending on the land use forecast model.
Effects of Hereditary and Acquired Risk Factors of Venous Thrombosis on a Thrombin Generation-Based APC Resistance Test

Summary Background Several hereditary and acquired risk factors for venous thromboembolism (VTE) are associated with impaired down-regulation of thrombin formation via the protein C pathway. To identify individuals at risk, functional tests are needed that estimate the risk to develop venous thrombosis. Method We determined the effects of hereditary and acquired risk factors of venous thrombosis on an APC resistance test that quantifies the influence of APC on the time integral of thrombin formation (the endogenous thrombin potential, ETP) initiated in plasma via the extrinsic coagulation pathway. APC sensitivity ratios (APCsr) were determined in plasma from carriers of factor VLeiden (n = 56) or prothrombin G20210A (n = 18), of individuals deficient in antithrombin (n = 9), protein C (n = 7) or protein S (n = 14) and of women exposed to acquired risk factors such as hormone replacement therapy (n = 49), oral contraceptive use (n = 126) or pregnancy (n = 35). We also analysed combinations of risk factors (n = 60). Results The thrombin generation-based APC resistance test was sensitive for the factor VLeiden and prothrombin G20210A mutation, to protein S deficiency, hormone replacement therapy, oral contraceptive use and pregnancy. The assay was not influenced by antithrombin-or protein C deficiency. The presence of more than one risk factor of venous thrombosis resulted in more pronounced APC resistance. The APCsr of individuals with a single or combined risk factors of VTE correlated well with reported risk increases. Interpretation The thrombin generation-based APC resistance test identifies individuals at risk for venous thrombosis due to acquired risk factors and/or hereditary thrombophilic disorders that affect the protein C pathway.
Different chemokine expression in lethal and non‐lethal murine west nile virus infection

West Nile (WN) virus is a mosquito‐borne flavivirus that can cause lethal encephalitis in humans and horses. The WN virus endemic in New York City (NY) in 1999 caused large‐scale mortality of wild birds that was not evident in endemic areas in other parts of the world, and the pathogenesis of the WN virus strain isolated in NY (NY strain) appears to differ from that of previously isolated strains. However, the pathogenesis of NY strain infection remains unclear. This study examined CC (RANTES/CCL5, MIP‐1α/CCL3, MIP‐1β/CCL4) and CXC (IP‐10/CXCL10, B lymphocyte chemoattractant (BLC/CXCL13), and B cell‐ and monocyte‐activating chemokine (BMAC/CXCL14)) chemokine expression during lethal NY strain and non‐lethal Eg101 strain infection in mice. We found that the mRNA of the CC chemokines, RANTES, MIP‐1α, MIP‐1β, and IP‐10 was highly up‐regulated in the brain of NY strain‐infected mice. By contrast, BLC mRNA was not detected in either group of mice, and BMAC mRNA was highly up‐regulated in late stage of infection with the non‐lethal Eg101 strain relative to levels in NY strain‐infected mice. J. Med. Virol. 74:507–513, 2004. © 2004 Wiley‐Liss, Inc.
A weighted average n-gram model of natural language

A new n-gram model of natural language designed to aid speech recognition is presented in which the probabilities are calculated as a weighted average of maximum likelihood probabilities obtained from a training corpus. This simple approach produces a model that can be constructed quickly and is easily adapted either by changing the weights or by changing the training corpus. The model is compared with two other models; the first is based on Turing-Good estimates and uses Katz's back-off approach. The second model is a deleted estimate model which combines different probability distributions in approximately optimal proportions. We introduce a new measure for language models based on their performance when predicting words removed randomly from samples of unseen text. The performance of all three models using both this new measure and the existing measure of perplexity have been compared. Results indicate that the performance of the new model is close to the performance of the deleted estimate model, while both are superior to the Turing-Good model.
Neighborhood-Aware and Overhead-Free Congestion Control for IEEE 802.11 Wireless Mesh Networks

It has been reported that the IEEE 802.11 MAC protocol and the TCP congestion control are highly problematic in terms of flow starvation in wireless mesh networks (WMNs). However, the economic features of IEEE 802.11 make it the commonly-used MAC protocol in WMNs. Therefore, solving starvation at the transport layer seems to be more appropriate. Indeed, the main starvation cause in TCP is that congestion is managed as a link-based problem. However, since bandwidth is a spatially-shared resource in WMNs, congestion is a neighborhood phenomenon that should be handled using mutual cooperation within a congested neighborhood. Such cooperation considerably consumes the already scarce bandwidth of WMNs causing more congestion. In this paper, we propose a neighborhood-aware and overhead-free congestion control scheme (NICC) that solves the starvation problem without impacting the scarce bandwidth of WMNs. NICC makes use of some underexploited fields in the IEEE 802.11 frame header, without modifying the standard frame size, to provide an overhead-free multi-bit congestion feedback; being overhead-free, this feedback allows performing neighborhood cooperation without generating control overhead. Furthermore, being multi-bit, it yields source nodes a fine-grained indication of the congestion degree, providing accurate rate control. The NICC performance in terms of starvation avoidance and bandwidth efficiency is proven through extensive simulations.
On case-based knowledge sharing in semantic Web

Human experience is a special kind of knowledge, which captures previously experienced, similar problem situations (case) for human problem solving. This paper describes a case-based approach for knowledge sharing and management with regard to the semantic web settings. We define a RDF-based Case Markup Language (CaseML) for experience knowledge representation and develop a generic architecture for the case based reasoning in the open, distributed environment with the emphasis on the integration of case knowledge with web ontologies. An application scenario from traditional Chinese medicine field is introduced to evaluate our methodology. With our application experience, we claim that, in contrast with logic-based knowledge representation formalisms, case is a more suitable for knowledge sharing in the semantic Web, because case based reasoning is similarity-based and there is weak demand on semantic consistent in such reasoning processes.
EFFECTS OF VALSARTAN ON STRESS-INDUCED CHANGES OF SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR AND NITRIC OXIDE IN MICE

This study investigated the effects of renin-angiotensin system (RAS) blockade on stress-induced changes of serum vascular endothelial growth factor (VEGF) and nitric oxide (NO) in mice. Chronic stress increased the serum NO levels significantly compared to control group (p = .0172). Valsartan, an angiotensin II receptor antagonist, alone, did not make significant difference versus control group. In chronic stress + valsartan group, serum NO levels decreased nonsignificantly compared to chronic stress group. There was a nonsignificant increase in serum VEGF levels after chronic stress. Valsartan alone or with chronic stress did not significantly affect the serum VEGF levels. In conclusion, there was no correlation between NO and VEGF changes during the stress response. In this respect, there may be other mechanisms to explain the stress-induced NO increase.
The paradox of resource availability and the perception of resource adequacy: the roles of psychological capital, perceived stress and age in the innovation process

ABSTRACT Technology development usually occurs in a complex and dynamic environment, whether it is corporate venturing or a start-up. To increase the likelihood of success, a better understanding of resource requirements for new product development (NPD) and venture creation is needed. Prior research is contradictory: some development projects succeed with an overabundance of resources, while others succeed with constraints. This article addresses the relationship between resource availability and perceptions of resource adequacy. A conceptual model is proposed that links entrepreneurial judgment to resource perceptions. Psychological capital (PsyCap) is proposed as a moderator of entrepreneurial perceptions, with perceived stress and age as mediating variables. The article generates research implications for entrepreneurship, proposing new variables that affect new product and new venture initiatives. These issues are at the marketing/entrepreneurship interface, since they affect innovation and the product mix as industry conditions shift and NPD becomes critical for the success of product management.
Pharmacological effects of GR138950, a novel angiotensin AT1 receptor antagonist.

The antagonist activity of GR138950 (1-[[3-bromo-2-[2-[[(trifluoromethyl)sulphonyl]amino]phenyl]-5- benzofuranyl]methyl]-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxamide) was investigated at angiotensin AT1 receptors and AT2 receptors in vitro and on blood pressure in conscious rats. GR138950 suppressed and displaced angiotensin II (AII) concentration-effect curves in the rabbit isolated aorta (pKb approximately 9.0-9.7) but had no effect against phenylephrine or serotonin induced-contractions. GR138950 competed with [3H]-AII for angiotensin AT1 receptors in rat liver membranes (pKi = 9.09). GR138950 had no apparent affinity for angiotensin AT2 receptors (bovine cerebellum; pKi < 6.0). GR138950 (1 mg/kg i.a. and p.o.) inhibited pressor responses to AII, but not phenylephrine, in conscious normotensive rats. Parallel displacements in AII dose-response curves occurred without any reduction in the maximum response to AII. The antagonist activity of GR138950 lasted for up to 24 h. GR138950 (> 0.03 mg/kg i.a., > 0.3 mg/kg p.o.) significantly reduced diastolic blood pressure (DBP) in renal artery ligated hypertensive rats. DBP was reduced maximally, 5 to 7 h after administration and the antihypertensive effect of GR138950 lasted for up to 48 h. Daily administration (5 days) of GR138950 to renal artery ligated hypertensive rats produced a sustained reduction in DBP. Acute administration of GR138950 (1 mg/kg i.a.) also significantly reduced DBP in spontaneously hypertensive rats but not in normotensive rats. Heart rate was little changed in renal artery ligated hypertensive rats, normotensive rats and spontaneously hypertensive rats. These experiments demonstrate that GR138950 is a potent, selective and specific angiotensin AT1 receptor antagonist that is orally active and reduces DBP in conscious hypertensive rats. (ABSTRACT TRUNCATED AT 250 WORDS)
Optical switch based on microring resonators and phase change materials

By exploiting the high contrast in the optical properties of the phase change material Ge<sub>2</sub>Sb<sub>2</sub>Te<sub>5</sub> between its amorphous and its crystalline stable phases (n<sub>cryst</sub>-n<sub>amor</sub>=2.5 and k<sub>cryst</sub>-k<sub>amor</sub>=1 at 1.55 μm) a thin film (20 nm) of this material deposited on top of a microring resonator can be used to modify its losses and effective refractive index, thus changing the position and shape of the resonances in the transmission spectrum.
c‐Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs

The human pathogen Helicobacter pylori colonizes the mucous layer of the stomach. During parasitic infection, freely swimming bacteria adhere to the gastric epithelial cells and trigger intracellular signalling pathways. This process requires the translocation of the effector protein CagA into the host cell through a specialized type IV secretion system encoded in the cag pathogenicity island. Following transfer, CagA is phosphorylated on tyrosine re‐sidues by a host cell kinase. Here, we describe how the tyrosine phosphorylation of CagA is restricted to a previously identified repeated sequence called D1. This sequence is located in the C‐terminal half of the protein and contains the five‐amino‐acid motif EPIYA, which is amplified by duplications in a large fraction of clinical isolates. Tyrosine phosphorylation of CagA is essential for the activation process that leads to dramatic changes in the morphology of cells growing in culture. In addition, we observed that two members of the src kinases family, c‐Src and Lyn, account for most of the CagA‐specific kinase activity in host cell lysates. Thus, CagA translocation followed by tyrosine phosphorylation at the EPIYA motifs promotes a growth factor‐like response with intense cytoskeletal rearrangements, cell elongation effects and increased cellular motility.
Diagnosis and management of aortic dissection.

Page Preamble . 1642 Introduction.1643 Aortic wall disease.1643 Inherited disease . 1643 Aortic disease in infancy and childhood . 1645 Ageing of the aorta.1645 Aetiology of aortic aneurysm and dissection . 1647 Aortic dissection staging . 1648 class 1 — classical aortic dissection . 1649 class 2 — intramural haemorrhage/haematoma.1649 class 3 — subtle/discrete aortic dissection.1650 class 4 — plaque rupture/ulceration.1650 class 5 — traumatic/iatrogenic aortic dissection . 1651 Clinical management . 1651 Clinical features . 1651 Initial diagnostic steps in the emergency room . 1652 Initial therapeutic decisions . 1653 Diagnostic requirements . 1654 Evolving — acute aortic dissection . 1654 Additional information.1657 Imaging modalities . 1658 Transthoracic/transoesophageal echocardiography (TTE/TEE) . 1659 Computed tomography.1660 Magnetic resonance imaging . 1661 Aortography . 1662 Intravascular ultrasound.1663 Surgical and interventional therapy . 1664 Surgical therapy . 1664 Interventional therapy by percutaneous stenting and/or percutaneous fenestration.1668 Indications for stent placement and fenestration.1668 Interventional techniques . 1669 Results of interventional therapy.1670 Complications of interventional therapy . 1670 Follow-up in aortic dissection . 1670 Natural history of aortic dissection and prognosis . 1670 Follow-up in Marfan patients . 1671 Imaging for follow-up studies.1672 Reoperation . 1672