Miracle-dz/UniFAR-FTUs huggingface dataset:
Hepatitis C : biomedical research reports

Molecular Biology of Hepatitis C Virus, M. Thomson and T.J. Liang. Hepatitis C: Viral Markers and Quasispecies, J.-M. Pawlotsky. Hepatitis C Virus Genotypes, P. Simmonds. Acute Hepatitis C, J.H. Hoofnagle. Natural History of Hepatitis C, L.B. Seeff. Pathology of Hepatitis C, D.E. Kleiner. Humoral Response to Hepatitis C Virus, A.J. Weiner, D. Chien, Q. -L. Choo, S. Coates, G. Kuo, and M. Houghton. Immunopathogenesis of Hepatitis C, B. Rehermann. Epidemiology of Hepatitis C, M.J. Alter, Y.J.F. Hutin, and G.L. Armstrong. Worldwide Prevalence and Prevention of Hepatitis C, D. Lavanchy and B. McMahon. Therapy of Chronic Hepatitis C, J.G. McHutchinson and J.H. Hoofnagle. Hepatitis C and Cirrhosis, G. Fattovich and S.W. Schalm. Hepatitis C and Hepatocellular Carcinoma, A.M. Di Bisceglie. Hepatitis C and Liver Transplantation, M. Berenguer and T.L. Wright. Mixed Cryoglobulinemia and Other Extrahepatic Manifestations of Hepatitis C Virus Infection, V. Agnello. Hepatitis C Virus and Human Immunodeficiency Virus Coinfection, M. Ghany and D.T. -Y Lau. Hepatitis C and Renal Disease, S. Zacks and M.W. Fried. Chronic Hepatitis C and Porphyria Cutanea Tarda, J.R. Bloomer. Hepatitis C Virus Infection and Alcohol, J. Everhart and D. Herion. Hepatitis C in Children, M.M. Jonas. Hepatitis C and Pregnancy, A.E. Semprini and A.R. Zanetti. Hepatitis C and Iron, J.K. Olynyk and B.R. Bacon. Complementary and Alternative Medicine in Hepatitis C, D.B. Strader and H.J. Zimmerman. Development of Novel Therapies for Hepatitis C, J.Y. N. Lau and D.N. Standring. Hepatitis C Vaccines, S. Gagneten and S.M. Feinstone. Index.
EFFET DE LA STIMULATION DU NOYAU PEDONCULOPONTIN SUR LES TROUBLES DE LA MARCHE ET LE FREEZING DANS LA MALADIE DE PARKINSON : ETUDE CLINIQUE ET THERAPEUTIQUE

Gait disorders in the healthy elderly are a major public health concern. We believed understanding Parkinson Disease (PD) typical gait disorders would bring some insights into the mechanisms of gait disorders in the elderly. In PD, their response to levodopa and to subthalamic nucleus stimulation is often heterogeneous, suggesting they are controlled at different levels of the CNS. In particular, there is convergent evidence of early alterations in cholinergic neurotransmission responsible for levodopa-resistant gait disorders in PD. An example comes from the observed link between executive dysfunction and the presence of levodopa-resistant freezing. Moreover, the relative preservation of executive functions in some patients suggests that other mechanisms may be involved in the development of levodopa-resistant freezing. The pedunculopontine nucleus area (PPNa) is a likely candidate. We report a beneficial effect of PPNa stimulation on freezing and falls related to freezing in some patients. However, our results are disappointing compared to the high levels of expectation raised by previous open label studies. Further controlled studies are needed to determine whether optimization of patient selection, targeting and setting of stimulation parameters might improve the outcome to a point that could transform this experimental approach to a treatment with a reasonable risk–benefit ratio.
DEMENCIA POR SOBRECRECIMIENTO BACTERIANO EN PACIENTE PORTADOR DE GASTRECTOMIA BILLROTH II

We report the case of a patient in the Psychiatric Department who complained of progressive impairment of cerebral functions consistent with dementia, diarrhea and fecal incontinence in the last few months. His medical history included a Billroth II gastrectomy for gastric ulcer. Biochemical tests detected cobalamine deficiency, without megaloblastic anemia, and an abnormal Shilling test that was not due to intrinsic factor deficiency. Once other causes of cobalamine deficiency were ruled out, we considered it as a deficiency disease due to blind loop syndrome. Treatment with parenteral vitamin B complex and long term oral antibiotic therapy allowed the complete and permanent resolution of neurologic and digestive symptoms.
The Cholesterol Content of Normal and Enlarged Prostates

The increase in the cholesterol content of malignant tumors as compared with that of normal surrounding tissues has been noted by Roffo (~:z), Jowett (~o), and Vargas (ZT). These observations have been confirmed by Yasuda ( i9 ) , Bierich, Detzel, and Lang (3), and Burgheim and Joel (6) who also found the cholesterol content of benign tumors to be considerably less than that of the malignant type of growth. Burgheim (5) and Chahovitch (8, 9) have shown tha t carcinomas are strongly positive to the Schultz histochemical reaction for cholesterol (~4-~6). Cathie (7), however, was unable to find any correlation between malignancy and a Schultz positive reaction. Dur ing the course of an investigation into the histology of enlarging prostates it was found that in most cases the Schultz reaction is more positive in the hyperplastic regions than elsewhere, the green color being most intense in the glandular cells themselves and much more marked than in normal prostates. It was therefore of interest to n-take quantitative observations on the cholesterol content of normal and enlarged prostates.
The new global threat : severe acute respiratory syndrome and its impacts

A disease that has given globalization a bad name, Severe Acute Respiratory Syndrome (SARS), has plagued no fewer than 30 areas in recent months. In this book, for the first time, leading scientists and researchers converge to shed light on the impacts and implications of this new global threat. Collected together within the volume are more than 20 articles that discuss and examine the SARS outbreak from wide-ranging perspectives -- political, social, economic and health. The reader is given insights into how the SARS outbreak has altered public and political understanding of the threat of infectious disease in general. There are lessons for global public health that have emerged from the response to SARS, especially as they pertain to preparedness for the next new disease. Informative but not heavy, insightful but not overwhelming, The New Global Threat: Severe Acute Respiratory Syndrome and Its Impacts is an indispensable source of information for anyone who wants to gain a better understanding of the hitherto unknown disease -- students, academics and corporate leaders alike.
Fundraising skills for health care executives

No one prepares the new dean or health care executive for the fund-raising aspect of their profession. Rather, it is one of the skills that is expected but not explicitly taught. Here, a former Dean and a Director of Major Gifts of a renowned nursing institution, with a combined 50 years in the profession, present an explicit, hands-on guide to successful fund-raising among individuals, foundations, and corporations. From the basic principles of development to the specifics of tax regulations and the, sometimes delicate, matter of stewardship, this book articulates strategies for success. Case studies, extensive support materials and illustrative tables makes this an accessible and indispensable tool for health renowned executives.
Spinal cord sensation : sensory processing in the dorsal horn : the proceedings of a satellite symposium of the International Congress of Physiological Sciences, held at Keszthely, Hungary, July 9-12, 1980

If you really want to be smarter, reading can be one of the lots ways to evoke and realize. Many people who like reading will have more knowledge and experiences. Reading can be a way to gain information from economics, politics, science, fiction, literature, religion, and many others. As one of the part of book categories, spinal cord sensation sensory processing in the dorsal horn always becomes the most wanted book. Many people are absolutely searching for this book. It means that many love to read this kind of book.
The Rehabilitation Model of Substance Abuse Counseling

Preface. 1. History and Background of Rehabilitation. 2. Drug and Alcohol History. 3. Conceptualizing Substance Abuse and Dependence: A Rehabilitation Perspective. 4. Drugs and the Central Nervous System. 5. Drugs of Abuse. 6. Group Counseling. 7. Family Counseling. 8. Treatment. 9. Assessment. 10. Treatment Planning, Case Management and Managed Care. 11. Special Populations. 12. Substance Abuse as a Coexisting Disability. 13. Alcohol, Drugs and Work. References. Index.
Dynamic Choice and Timing Indipendence: an experimental investigation

Timing-independence implies that individuals are indifferent between a sequential choice problem and a planned choice problem which are strategically equivalent except for the timing of resolution of the uncertainty. This paper reports an experiment in which we investigate whether the timing of resolution of the uncertainty affects individual preferences. We elicit individual preferences for three strategically equivalent decisions problems. The experimental results suggest that timing-independence is an inappropriate assumption of individual preferences. The paper discusses possible implications of such findings. JEL classifications: D81, C91, D90
Evidence-based interventions

 Although death from a sports injury is rare, the leading cause of death from a sportsrelated injury is a brain injury.  The highest rates of injury occur in sports that involve contact and collisions.  Most organized sports-related injuries (60%) occur during practice.  More severe injuries occur during individual sports and recreational activities. Evidence Based Interventions In recent years, concussions and traumatic brain injury (TBI) have brought sports injury significant media attention, however further work evaluating interventions is still needed. Based on current literature, the majority of effective sports injury interventions fall into three categories including behavioral interventions, environmental interventions, and policy change.
Introducing the Global Advocacy Leadership Academy (GALA): Training Health Advocates around the World to Champion the Needs of Health Care Consumers

Patient advocacy can make significant contributions to health research by ensuring that efforts are patient-focused and help promote cooperation between all relevant sectors of the health care community. Yet, the development of effective patient advocacy organizations demands strong leadership, establishment of active collaborations with key stakeholders, and careful management of fiscal and personnel resources to enhance health outcomes. This presentation describes the development and implementation of an innovative training academy to prepare cancer advocacy leaders, both domestically and internationally, by helping them carefully consider strategic health advocacy processes, roles, and responsibilities. The Global Advocacy Leadership Academy (GALA) will provide participants with a comprehensive overview of the modern health care system, identifying critical constituents and stakeholders, and examining interrelationships between key individuals and organizations. Strategies for fostering meaningful communication, cooperation, and coordination between patient advocacy organizations and other stakeholders related to health, including consumers, other advocacy groups, clinicians, government officials, researchers, and private industry representatives, will also be explored. For example, patient advocacy organization leaders will learn about communication strategies for working effectively with researchers and clinicians to support prevention, detection, treatment, and survivorship efforts that will benefit patients. Patient advocacy organization leaders will also explore strategies for raising funds and increasing funding for health research. They will learn about clinical research, health regulatory systems, community organizing, as well as drug and technology development and approval processes from basic research to clinical practice. Exemplar models of successful patient advocacy organization leadership will be described and evaluated as GALA case studies that illustrate effective health
Analysis of a Novel JK-1 Gene Expression in Benign and Malignant Colorectal Tumors

Introduction: Colorectal tumors are amongst the most common neoplasms affecting individuals in industrialized nations. A newly discovered gene, JK-1 (FAM134B) located in chromosome 5 p15.2 plays an important role in molecular pathogenesis of esophageal cancer. This study aims at examining the role of this gene in colorectal tumors by analyzing the differences in gene mRNA expression in both benign and malignant colorectal tumors in comparison with non-neoplastic samples of colorectal tissue. Methods: The study was performed on 162 colorectal adenocarcinoma, 32 benign adenoma and 20 non-neoplastic colorectal tissues. mRNA was extracted from the prospectively collected tissues and converted into cDNA. Primers were designed for the JK-1 gene and gene expression levels were determined using real-time PCR. The expression levels were calculated as a ratio of the Ct value for JK-1 to GAPDH (housekeeping gene) and expressed as inverse ratio to reflect the changes in gene expression. Results: The JK1 mRNA was detected in all colorectal tissues. The mean inverse ratio for JK-1 gene in adenoma samples was 0.929 ᠰ. 005 which was significantly higher than in non-tumor samples which was 0.901 ᠰ. 009 (p=0.005). On the other hand, cancer samples had a mean inverse ratio of 0.875 ᠰ. 006 which was significantly lower than in non-tumor tissues (p<0.001). Conclusions: The results of this study indicate that JK-1 expression has a role in the carcinogenesis in colorectal cancer. The under-expression of the gene in cancer suggests that loss of gene expression may promote tumor progression, that it may act as a tumor suppressor gene or that it relates to certain genetic events in tumor pathogenesis. However, over-expression of JK-1 in adenoma samples may indicate that JK-1 has a functional role in dysplastic benign colon tumors, a function that is disrupted once the tumor progresses to a more invasive form.
O papel dos hormônios tireoidianos na função testicular

Thyroid hormones play an important role in the growth, development, and metabolism of mammalian tissues. The prohormone thyroxine (T4) is synthesized and secreted by the thyroid gland together with a small amount of the active hormone, triiodothyronine (T3). The iodothyronine deiodinases types 1 and 2 catalize the peripheral T4 to T3 conversion. To exert its biological effects T3 interact with specific membrane transporters and nuclear receptors, thus activating gene transcription. Classically, male gonads were considered to be unresponsive to thyroid hormones. Recent studies, however, have shown that thyroid hormones have a critical role in the male reproductive system, not only during development, but also in adult life. Hence, we review and discuss the most recent advances in our understanding of thyroid hormone effects in male gonadal function.
Obstetric outcome after single embryo transfer

Obstetric outcome after single embryo transfer Department of Obstetrics and Gynecology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, SE-413 45 Gothenburg, Sweden. Background: Children born after IVF have a poorer neonatal outcome than children born after spontaneous conception, even after adjustment for confounders. In Sweden, since 2003 an increasing amount of IVF cycles are single embryo transfers (SET). This gives the opportunity to investigate and compare the outcome after SET and double embryo transfers (DET). Aim: To assess the neonatal and maternal outcomes after IVF, particularly after SET. Methods: Paper I: All IVF children born in Sweden after IVF treatment during the years 2002-2006 and their mothers were included (n=13 544 children) and compared with all children in the general population born during the same time period and their mothers (n=587 009 children) concerning neonatal and maternal outcomes. Paper II: All IVF singletons born after fresh IVF cycles and own oocytes were included (n= 8941) and cross-linked with the Swedish Medical Birth Registry. Four major outcomes were investigated: very preterm birth (<32 weeks), small for gestational age (SGA), placenta previa and placental abruption. Maternal characteristics (age, parity, BMI, smoking and years of infertility) and treatment-related variables (number of oocytes retrieved, number of embryo culture days, number of transferred and cryopreserved embryos and “vanishing twin”) were investigated for independent association with the four selected outcomes. Paper III: All singletons after cryopreserved (n=2348) and fresh IVF cycles (n=8944) were included and compared with all singletons born after spontaneous conception (n=571 914). Paper IV: Outcomes for women (n=921) undergoing two IVF pregnancies with singletons (n=1842) were compared with women (n=991) undergoing one IVF pregnancy with twins (n=1982). Results: Paper I: Children born after IVF had a poorer neonatal outcome than children in the general population. Comparing IVF singletons, irrespective of the number of embryos transferred, with singletons in the general population, significantly higher rates of preterm birth ( 4500g) were higher for singletons after cryopreservation cycles than for…
Compressional, mechanical and release properties of a novel gum in paracetamol tablet formulations

ABSTRACT The binding properties of Eucalyptus gum obtained from the incised trunk of Eucalyptus tereticornis, were evaluated in paracetamol tablet formulations, in comparison with that of Gelatin B.P. In so doing, the compression properties were analyzed using density measurements and the compression equations of Heckel, Kawakita and Gurham. In our work, the mechanical properties of the tablets were assessed using the crushing strength and friability of the tablets, while the drug release properties of the tablets were assessed using disintegration and dissolution times. The results of the study reveal that tablet formulations incorporating Eucalyptus gum as binder, exhibited faster onset and higher amount of plastic deformation during compression than those containing gelatin. What is more, the Gurnham equation could be used as a substitute for the Kawakita equation in describing the compression properties of pharmaceutical tablets. Furthermore, the crushing strength, disintegration and dissolution times of the tablets increased with binder concentration, while friability values decreased. We noted that no significant differences in properties exist between formulations derived from the two binders (p > 0.05) exist. While tablets incorporating gelatin exhibited higher values for mechanical properties, Eucalyptus gum tablets had better balance between mechanical and release properties - as seen from the CSFR/Dt values. Tablets of good mechanical and release properties were prepared using Eucalyptus gum as a binder, and, therefore, it could serve as an alternative binder in producing tablets with good mechanical strength and fast drug release.
Ovine maternal and fetal cardiovascular effects of the serotonergic agonist R(-)-2,5-dimethoxy-4-methyl-amphetamine and characterization of serotonergic receptors in the ovine uterine and umbilical vessels

Pregnant ewes and their fetuses were instrumented between 110 to 120 days of gestation (term, 145 days) for monitoring heart rate, blood pressure, uterine artery blood flow, and fetal intra-abdominal umbilical artery blood flow and arterial blood gases. DOM (2,5-dimethoxy-4methyl-amphetamine) was administered intravenously to the ewe in doses of 1, 2.5, 5, 10, or 20 fig/kg. Maternal administration of DOM produced dose-dependent increases in maternal blood pressure and a fall in the heart rate. Uterine blood flow was dramatically decreased by DOM and uterine vascular resistance increased by 6.8, 16.7 and 19.6 fold after DOM at 5, 10, and 20 ftg/kg, respectively. These responses were accompanied by fetal hypoxemia, combined metabolic and respiratory acidosis, hypertension and bradycardia. The changes in blood flow and vascular resistance were always smaller in the fetal umbilical artery than those in the maternal uterine artery. The maximal rise in vascular resistance in the fetal umbilical artery was 2.6 fold after DOM (20 fig/kg). Ketanserin (1 mg/kg), administrated 30 minutes prior to the administration of DOM, inhibited maternal and fetal cardiovascular and blood gas responses to DOM. The conclusions are: (1) the fetus is distressed following maternal administration of DOM brought about by a ^Submitted to J. Pharmacol. Exp. Ther. as a research paper by Lubo Zhang, Donald C. Dyer, Frederick B. Hembrough and Miguel Isla.
UNCOMMON TYPES OF DISC HERNIA ( A REPORT OF THREE CASES AND REVIEW OF LITERATURE)

Background : Spinal disc hernia is prolapse of nucleus pulposus through a defect in annulus fibrosus. Over 90% of cases occur in the lumbar spine with only 1% being thoracic. Sequestered disc hernia is the last spectrum of progression of disc hernia with formation of mobile free fragment. Aim : To add to literature documentation of uncommon types of disc hernia Case Reports : CASE 1 : A 63year old Cameroonian man with L4/L5 sequestered disc hernia, seen posterior to L5 vertebral body. He had discectomy and symptomatic reliefs were better than pre-operative status conforming to McCulloch’s clinical outcome grade 3. CASE 2 : A 34year old male Cameroonian with chronic back pain and paraesthesia following trauma. Thoracic spine Magnetic resonance imaging (MRI) revealed T11/T12 disc hernia with severe epidural compression. He declined discectomy for an Overseas treatment. CASE 3 : A 72year old male Nigerian who had L3/L4 iatrogenic spinal fusion 5years ago. Lumbo-sacral spine MRI following recurrent low back pain showed L2/L3 and L4/L5 disc hernias. The L2/L3 hernia above the bony ankylosis interestingly is severer than L4/L5 hernia. He was managed conservatively. Conclusion : MRI increasing availability in Central Africa will detect more cases of uncommon types of disc hernias.
Availability and use of UK based ethnicity data for health research

The aim of this working paper is to inform researchers of the availability of ethnicity data in population based datasets which are available for use in epidemiological and social science research. The paper begins by introducing the concept of ethnicity and problems associated with definition and classification. Secondly, the paper charts the evolution of ethnicity recording in the UK census and how this has been incorporated across the NHS. Thirdly, the paper focuses down on to the relationship between ethnicity and health and describes electronic NHS databases in which routinely collected ethnicity data are available for research purposes. Finally, the paper briefly reviews existing work on ethnicity and health which has been undertaken using population wide data from the ONS Longitudinal Study and NHS databases.
Structural interventions in invasive cardiology

• A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.