Miracle-dz/UniFAR-FTUs huggingface dataset:
Post-traumatic chronic bone and joint infection caused by Butyricimonas spp, and treated with high doses of ertapenem administered subcutaneously in a 30-year-old obese man

An obese but otherwise healthy 30-year-old man presented with septic pseudarthrosis following a post-traumatic open radial fracture. Three months earlier, the patient had been involved in a truck accident and suffered a distal open radial fracture associated with compartment syndrome (figure 1A). Primary management consisted of wound debridement, fasciotomy, stabilisation with external fixation and antibiotic prophylaxis with amoxicillin-clavulanate. The wound healed after 1 month (figure 1B). Due to pseudarthrosis (figure 1C, D), the patient returned to the operating room for internal fixation. He did not have fever, and there was no local sign of inflammation and no fistula; …
Design and analysis of interdigital microstrip bandpass filter for centre frequency 2.4 GHz

The main aim of this paper is to design an interdigital microstrip bandpass filter which operates at a frequency of 2.4 Ghz which will be more applicable for use in the wireless communication. The interdigital bandpass filter is designed for order n=3, n=5, n=7. ADS software is used to design the filter. The simulation results of each order filter was analyzed. The 5th order filter is found to have better results when compared with the other two filters. The designed filter is fabricated on a FR-4 substrate which has a relative dielectric constant εr of 4.4. The filter gives an insertion loss of −2db and return loss of −18db which can be obtained from the magnitude vs frequency graphs.
On the Green's Functions of Quantized Fields: I.

The temporal development of quantized fields, in its particle aspect, is described by propagation functions, or Green’s functions. The construction of these functions for coupled fields is usually considered from the viewpoint of perturbation theory. Although the latter may be resorted to for detailed calculations, it is desirable to avoid founding the formal theory of the Green’s functions on the restricted basis provided by the assumption of expandability in powers of coupling constants. These notes are a preliminary account of a general theory of Green’s functions, in which the defining property is taken to be the representation of the fields of prescribed sources.
Crystals and fibrils in chromoplast plastoglobules of Solanum capsicastrum fruit

The fine structure of the fibrils and crystals, associated with the chromoplast plastoglobules of ripening Solanum capsicastrum fruit, was investigated: (1) in thin sections of fixed tissue and (2) in isolates prepared from fresh tissue, subjected to negative staining and metal shadowing. Electron micrographs of thin sections, particularly when combined with TCH-Ag-proteinate staining, afforded particularly clear insights into the ultrastructure of the fibrils and their formation next to the plastoglobules, while the crystals were seen only in transverse section. In the negatively stained isolates, on the other hand, the crystals were well visible as elongated platelets, which could be as short as 1 mm and only about 1.5 nm thick. They were occasionally aggregated into clusters with irregular outlines, about 2–3 mm in diameter. The crystals likely contained carotenoids and their structure was comparable to the large carotene crystals found in other plants.
Increased IL-10 Production and HLA-DR Suppression in the Lungs of Injured Patients Precede the Development of Nosocomial Pneumonia

The incidence of nosocomial pneumonia (NP) among injured patients is substantial. We hypothesize that traumatic injury induces alterations in local organ effector cell function that may predispose the lungs of injured patients to infection. It is the objective of this study to compare the systemic and alveolar effector cell response to injury and assess the relationship these have to the development of NP. Peripheral blood and bronchoalveolar lavage fluid (BAL) were collected from 10 elective surgery patients (controls) and 16 multitrauma patients at 12, 36, and 60 h post-injury. Systemic and alveolar levels of IL-8 and IL-10 were measured. CD11b expression on peripheral blood neutrophils (PBN) and alveolar neutrophils (AN) and HLA-DR expression on peripheral blood monocytes (PBM) and alveolar macrophages (AM) were measured. Alveolar levels of IL-8 and IL-10 were significantly higher than systemic levels after injury. HLA-DR expression was reduced on both PBM and AM after injury but was lowest on the AM. Six of 16 patients (38%) developed NP (NP+). There were no differences in cytokine levels (IL-8 and IL-10) or effector cell phenotype (CD11b and HLA-DR expression) within the systemic circulation of NP+ and NP− patients. In contrast, NP+ and NP− patients differed significantly in alveolar cytokine levels and alveolar effector cell phenotype. IL-8 was significantly higher in BAL form NP+ patients at all time points after injury. Furthermore, alveolar levels of IL-10 decreased in NP− patients but increased in NP+ patients. In all patients, AM HLA-DR expression was significantly reduced from normal controls 12 h post-injury. In NP− patients, AM HLA-DR expression returned to normal 60 h post-injury, whereas in NP+ patients, expression remained suppressed. These findings identify distinct trends in local organ cytokine production and alterations in effector cell phenotype that precede NP. The persistence of reduced HLA-DR expression amidst increasing levels of IL-10 in NP+ patients suggest that cell-mediated immune function is being suppressed. As such, local organ immunosuppression may be responsible for the development of nosocomial pneumonia in injured patients.
Certification and Education: Do They Affect Pressure Ulcer Knowledge in Nursing?

OBJECTIVE: To determine whether wound care certification and education affect nursing knowledge. This study examined pressure ulcer knowledge among registered nurses who were (1) certified in wound care, (2) certified in specialty areas other than wound care, or (3) not certified in any specialty area. DESIGN: A convenience sample of 460 nurses, located in both urban and rural areas, provided demographic information and completed a standardized pressure ulcer knowledge test using (Pieper Pressure Ulcer Knowledge Tool). RESULTS: The mean standardized test score for the total sample was 78%, with nurses certified in wound care scoring 89%, nurses certified in specialties other than wound care scoring 78%, and nurses receiving no certification scoring 76.5%. CONCLUSION: Wound care certification and education significantly affect nursing knowledge.
Maximum-intensity-projection images of human sweat glands using optical coherence tomography

We demonstrate for the first time the maximum intensity projection (MIP) for OCT, on the analogy of the X-ray CT, where a spiral duct of sweat glands on human fingertip is observed very clearly. The MIP OCT is a quick 3D-image construction method suitable for dynamic analysis of mental-stress-induced sweating.
Neurobehavioural treatment for obsessive-compulsive disorder in an adult with traumatic brain injury

Although obsessive-compulsive disorder has been reported as one of many anxiety-related sequelae of brain injury, few empirical data of its responsiveness to psychological intervention are available. In this study, a single participant changing criterion experimental design was used to evaluate a neurobehavioural intervention for compulsive behaviour of an adult with severe traumatic brain injury. The participant, a man aged 24 years, had sustained frontal-temporal lobe brain trauma 12 months earlier, and presented with compulsive counting and voiding of bladder. The neurobehavioural intervention consisted of regular in-home consultations, self-regulation procedures including self-recording of compulsive behaviour, stress-coping strategies, errorless remediation, social reinforcement, and gradual fading of intervention. Baseline showed counting occurred on average 80% of daily hourly intervals, and voiding 12 times per day. Intervention produced elimination of compulsive counting, acceptable voiding at 8 times per day, and reports of the participant's satisfaction with intervention methods and outcomes. At 6 months follow-up, counting remained at zero levels, and voiding had decreased further to 7 times per day.
Maximum-Likelihood Estimation of Discretely Sampled Diffusions: A Closed-Form Approach

When a continuous-time diffusion is observed only at discrete dates, not necessarily close together, the likelihood function of the observations is in most cases not explicitly computable. Researchers have relied on simulations of sample paths in between the observations points, or numerical solutions of partial differential equations, to obtain estimates of the function to be maximized. By contrast, we construct a sequence of fully explicit functions which we show converge under very general conditions, including non-ergodicity, to the true (but unknown) likelihood function of the discretely-sampled diffusion. We document that the rate of convergence of the sequence is extremely fast for a number of examples relevant in finance. We then show that maximizing the sequence instead of the true function results in an estimator which converges to the true maximum-likelihood estimator and shares its asymptotic properties of consistency, asymptotic normality and efficiency. Applications to the valuation of derivative securities are also discussed.
Nitrofurantoin rechallenge and recurrent toxicity.

A 60-year-old woman was admitted as an emergency with progressive dyspnoea over the previous eight months becoming more rapid over the previous eight weeks. She was markedly dyspnoeic when walking more than 50 yards on level ground, had a nonproductive cough and complained of recent weight loss. She denied being on any medication or having had previous allergies and her only previous complaint had been of recurrent cystitis. Examination revealed bilateral fine crackles in her mid-zones but she did not have finger clubbing. The rest of the examination was normal. Her chest X-ray was suggestive of interstitial fibrosis (figure (A)), her arterial pAO2 at rest was 9.2 mmHg and her forced vital capacity (FVC) was 1.61 litres (predicted 3.27). Transfer factor for carbon monoxide (tCO) was reduced to 11.91 ml/min/mmHg (predicted 23.15). Liver function tests were also deranged with an aspartate transaminase of 93 IU/1 (normal 12-30), gamma-glutamyltransferase of 57 IU/1 (5-35) and alkaline phosphatase 156 IU/1 (40-110) but the bilirubin was normal and her erythrocyte sedimentation rate (ESR) was 23 mm/h. Renal function was normal. On specific questioning about whether she might be taking any medications, particularly for prevention of cystitis, she recalled that she had been prescribed by her general practitioner a urinary, 'antiseptic' tablet which she had taken at night for more than a year but she had not considered it to be a drug. It was subsequently identified as nitrofurantoin 50 mg. A working diagnosis of nitrofurantoininduced interstitial pulmonary fibrosis was made, the drug was stopped and she improved gradually such that eight weeks later her tCO had risen to 16.93 and her chest X-ray is shown in the figure (B). Seven months after drug withdrawal, her tCO was 21.9, FVC was 3.19 1 and her liver function tests were normal. She could walk up to a mile on level ground without dyspnoea. Subsequent examination of previous medical records from another hospital revealed that she had been referred to a consultant neurologist 16 years earlier with a history of numbness, pins and needles and tingling of the lower limbs up to mid thigh which occurred 14 days after a 10-day course of nitrofurantoin had been completed for an episode of cystitis. By the time she was seen by the neurologist three months later, there was possible diminished sensation of stocking distribution in the left leg (the right leg was in plaster after a fracture) but no other neurological abnormalities and liver and renal function was normal. Her ESR was 33 mm/h. The neurologist felt that the history indicated that her previous symptoms were likely to be drug-related and advised her general practitioner that she should 'never be prescribed nitrofurantoin again. '
Experience with HSP90 inhibitor AUY922 in patients with relapsed or refractory non-Hodgkin lymphoma

Heat shock protein 90 (HSP90) plays an important role in normal and malignant cells by stabilizing chaperone proteins. It is frequently overexpressed in lymphoma, is known to contribute to the stability of oncoproteins and is thus an attractive target of treatment. [1][1] While first generation HSP90
A study of manufacturer-supported trials of nonsteroidal anti-inflammatory drugs in the treatment of arthritis.

BACKGROUND To study the relation between reported drug performance in published trials and support of the trials by the manufacturer of the drug under evaluation, we studied a sample of trials of nonsteroidal anti-inflammatory drugs (NSAIDs) used in the treatment of arthritis. METHODS All randomized control trials of NSAIDs published between September 1987 and May 1990 identified by MEDLINE were reviewed. If an article met the following criteria (n = 61), it was selected: trials involving adult patients with osteoarthritis or rheumatoid arthritis (n = 180), use of nonsalicylate NSAIDs marketed in the United States (n = 101), randomized control trial (n = 81), duration of the trial 4 or more days (n = 78), and use of an efficacy outcome measure (n = 61). Reviewers, "blinded" to manufacturer status, evaluated the narrative interpretation of results and extracted numeric data on efficacy and toxicity. Manufacturer-associated trials were defined as those that acknowledged an association with a pharmaceutical manufacturer. Because of the scarcity of non-manufacturer-associated trials (n = 9), we report only on the manufacturer-associated articles. RESULTS Fifty-two publications (85.2%) representing 56 trials were associated with a manufacturer. The manufacturer-associated drug was reported as comparable with (71.4%) or superior to (28.6%) the comparison drug in all 56 trials. These narrative claims of superiority were usually justified with trial data. Of the trials identifying one drug as less toxic (n = 22), the manufacturer-associated drug's safety was reported as superior to the comparison drug in 86.4% of cases. Justification for the narrative interpretation of the trial findings regarding less toxicity was provided in only 12 (54.5%) of 22 trials. CONCLUSION The manufacturer-associated NSAID is almost always reported as being equal or superior in efficacy and toxicity to the comparison drug. These claims of superiority, especially in regard to side effect profiles, are often not supported by trial data. These data raise concerns about selective publication or biased interpretation of results in manufacturer-associated trials.
Cistrome of the aldosterone‐activated mineralocorticoid receptor in human renal cells

Aldosterone exerts its effects mainly by activating the mineralocorticoid receptor (MR), a transcription factor that regulates gene expression through complex and dynamic interactions with coregulators and transcriptional machinery, leading to fine‐tuned control of vectorial ionic transport in the distal nephron. To identify genome‐wide aldosterone‐regulated MR targets in human renal cells, we set up a chromatin immunoprecipitation (ChIP) assay by using a specific anti‐MR antibody in a differentiated human renal cell line expressing green fluorescent protein (GFP)‐MR. This approach, coupled with high‐throughput sequencing, allowed identification of 974 genomic MR targets. Computational analysis identified an MR response element (MRE) including single or multiple half‐sites and palindromic motifs in which the AGtACAgxatGTtCt sequence was the most prevalent motif. Most genomic MR‐binding sites (MBSs) are located >10 kb from the transcriptional start sites of target genes (84%). Specific aldosterone‐induced recruitment of MR on the first most relevant genomic sequences was further validated by ChIP‐quantitative (q)PCR and correlated with concomitant and positive aldosterone‐activated transcriptional regulation of the corresponding gene, as assayed by RT‐qPCR. It was notable that most MBSs lacked MREs but harbored DNA recognition motifs for other transcription factors (FOX, EGR1, AP1, PAX5) suggesting functional interaction. This work provides new insights into aldosterone MR‐mediated renal signaling and opens relevant perspectives for mineralocorticoid‐related pathophysiology. —Le Billan, F. , Khan, J. A. , Lamribet, K. , Viengchareun, S. , Bouligand, J., Fagart, J., Lombès, M. Cistrome of the aldosterone‐activated mineralocorticoid receptor in human renal cells. FASEB J. 29, 3977‐3989 (2015). www.fasebj. org
A simple hierarchical approximation RBF neural network

The approximation algorithm introduced by Asim Roy et al. (1997) generates a hybrid neural network with RBF neurons and other types of hidden neurons for function approximation. The network is trained in stages, with RBF neurons at the early stages corresponding to general features in the space and those in later stages corresponding to more specific features. The other types of hidden neurons are added with a view to improving generalization and reducing the number of RBF neurons. The algorithm uses linear programming to design and train the hybrid network. We investigate simplifying the algorithm with a view to eliminating the need for the other types of hidden neurons and linear programming. The simple hierarchical approximation algorithm ('SHA') achieves comparable results in terms of accuracy without the added complexity introduced by the other types of hidden neurons.
Yes or no? How young French children combine gestures and speech to agree and refuse

The aim of the study presented here was to examine variations in the forms and functions of agreement and refusal messages – which can be solely gestural, solely verbal, or combined gestural and verbal – by thirty children aged 1;4, 2;0, and 3;0 (ten in each age group) observed at home during an interaction with their mother. The results showed that even though verbal forms were the predominant ones as a whole, gestural forms were carried over into the linguistic period, and for the youngest children, constituted the sole means of agreeing and refusing. They also showed that the most frequently expressed function was assertion.
Music Therapy as Procedural Support for Young Children Undergoing Immunizations: A Randomized Controlled Study.

BACKGROUND Children undergoing routine immunizations frequently experience severe distress, which may be improved through music therapy as procedural support. OBJECTIVE The purpose of this study was to examine effects of live, cognitive-behavioral music therapy during immunizations on (a) the behaviors of children, their parents, and their nurses; and (b) parental perceptions. METHODS Participants were children between the ages of 4 and 6 years (N = 58) who underwent immunizations, their parents (N = 62), and the nurses who administered the procedure (N = 19). Parent/child dyads were randomly assigned to receive music therapy (n = 29) or standard care (n = 29) during their immunization. Afterward, each parent rated their child's level of pain and the distress their child experienced compared to previous medical experiences. All procedures were videotaped and later viewed by trained observers, who classified child, parent, and nurse behaviors using the categories of the Child-Adult Medical Procedure Interaction Scale-Revised (CAMPIS-R). RESULTS Significant differences between the music therapy and control groups were found in rates of child coping and distress behaviors and parent distress-promoting behaviors. Parents of children who received music therapy reported that their child's level of distress was less than during previous medical experiences, whereas parents of children in the control group reported that their child's level of distress was greater. No significant differences between groups were found in parents' ratings of children's pain or in rates of nurse behavior. CONCLUSIONS Live, cognitive-behavioral music therapy has potential benefits for young children and their parents during immunizations.
Stroke in Children and Young Adults

placed infarcts, lacunar infarcts in the deep grey and white matter, extensive ischaemic white matter lesions, or a combination of these. The problem is, of course, that without a brain biopsy all these patients may have coincidental Alzheimer's disease. White matter lesions receive a lot of attention. If the clinical picture resembles Alzheimer's then their contribution to the dementia is likely to be restricted. If, on the other hand, the patient has less profound impairments in episodic memory, more depressive symptomatology and a gait disturbance, then the white matter lesions (which may be due to vascular disease) are probably pertinent to the clinical presentation. Binswanger's disease remains a mystery. If the ischaemic demyelination is due to hypoperfusion of the white matter why haven't we got eloquent PET data to show high OEF and low CMRO2? Cummings has written a useful chapter on the clinical characteristics of patients with presumed vascular sub-cortical dementia. Subcortical damage arises from small vessel disease which may give rise to a lacu-
Effect of Felodipine on Renal Hemodynamics and Excretion in the Dog

Abstract The effects of felodipine on renal hemodynamics and excretion were evaluated in the anesthetized dog. Unilateral renal arterial infusion of felodipine produced ipsilateral increases in the absolute and fractional excretion of sodium and water which were greater than those of potassium; these effects occurred in the absence of changes in mean arterial pressure, renal blood flow, or glomerular filtration rate. There were no significant effects on renal hemodynamic or excretory function in the contralateral kidney. The unilateral renal arterial infusion of isotonic saline or vehicle produced no significant effects on renal hemodynamic or excretory function in either ipsilateral or contralateral kidney. Felodipine, a calcium antagonist with vasodilator antihypertensive properties, in doses which do not affect systemic or renal hemodynamics in the dog, increased urinary flow rate and sodium excretion by decreasing renal tubular water and sodium reabsorption. As a vasodilator antihypertensive agent, felodipine possesses potentially advantageous diuretic and natriuretic properties.
Increasing options for the treatment of osteoporosis.

More than a decade ago, receptor activator of nuclear factor-κB ligand (RANKL) was identified as the key molecule mediating osteoclast development, activity, and survival.1 Since osteoporosis results, in part, from increased osteoclastic bone resorption, the inhibition of RANKL activity has been an obvious therapeutic target. In this issue of the Journal, two articles2,3 report pivotal studies that reflect more than 10 years of drug development and that establish the efficacy of a human monoclonal antibody to RANKL, denosumab, in reducing fractures. Cummings et al.2 enrolled 7868 postmenopausal women with osteoporosis and randomly assigned them to receive either 60 .