Miracle-dz/UniFAR-FTUs huggingface dataset:
Interferon‐γ‐induced chromatin remodeling at the CIITA locus is BRG1 dependent

SWI/SNF regulates growth control, differentiation and tumor suppression, yet few direct targets of this chromatin‐remodeling complex have been identified in mammalian cells. We report that SWI/SNF is required for interferon (IFN)‐γ induction of CIITA, the master regulator of major histocompatibility complex class II expression. Despite the presence of functional STAT1, IRF‐1 and USF‐1, activators implicated in CIITA expression, IFN‐γ did not induce CIITA in cells lacking BRG1 and hBRM, the ATPase subunits of SWI/SNF. Reconstitution with BRG1, but not an ATPase‐deficient version of this protein (K798R), rescued CIITA induction, and enhanced the rate of induction of the IFN‐γ‐responsive GBP‐1 gene. Not ably, BRG1 inhibited the CIITA promoter in transient transfection assays, underscoring the importance of an appropriate chromosomal environment. Chroma tin immunoprecipitation revealed that BRG1 interacts directly with the endogenous CIITA promoter in an IFN‐γ‐inducible fashion, while in vivo DNase I footprinting and restriction enzyme accessibility assays showed that chromatin remodeling at this locus requires functional BRG1. These data provide the first link between a cytokine pathway and SWI/SNF, and suggest a novel role for this chromatin‐remodeling complex in immune surveillance.
Role of platelet rich plasma in osteoarthrosis of knee joint among south Indian populaton

Aim: The purpose of this prospective study is to clinically evaluate the efficacy of treatment for knee osteoarthrosis using platelets rich plasma injection. Materials and Methods: This study was performed between January 2018 and June 2018 at the Government Coimbatore Medical College and Hospital as a day care procedure. Eighty patients with knee osteoarthrosis are treated with platelet-rich plasma and studied. Primary data collection was performed using questionnaire tool VAS and WOMAC. Results: All patients in this study completed a questionnaire on pre-injection, 8 weeks post-injection and12 weeks follow up visits using the VAS andWOMAC score. After 3 months the VAS score was 1.8 (p and the WOMAC score improved from 78 to 32 (p Conclusion: This study suggests using platelet rich plasma in osteoarthrosis of the knee joint as a cost effective and less complicated approach to relieve pain and improve day to day activities. Keywords: Knee osteoarthrosis, Knee joint, Platelet rich plasma.
Gα15 and Gα16 Couple a Wide Variety of Receptors to Phospholipase C (*)

The murine G-protein α-subunit Gα15 and its human counterpart Gα16 are expressed in a subset of hematopoietic cells, and they have been shown to regulate β-isoforms of inositide-specific phospholipase C. We studied the ability of a variety of receptors to interact with Gα15 and Gα16 by cotransfecting receptors and G-protein α-subunits in COS-7 cells. Activation of β2 adrenergic and muscarinic M2 receptors in cells expressing the receptors alone or together with Gαq, Gα11, or Gα14 led to a very small stimulation of endogenous phospholipase C. However, when the receptors were coexpressed with Gα15 and Gα16, addition of appropriate ligands caused a severalfold increase in inositol phosphate production which was time- and dose-dependent. A similar activation of phospholipase C was observed when several other receptors which were previously shown to couple to members of the Gi and Gs family were coexpressed with Gα15. In addition, stimulation of inositol phosphate formation via receptors naturally coupled to phospholipase C was enhanced by cotransfection of Gα15 and Gα16. These data demonstrate that Gα15 and Gα16 are unique in that they can be activated by a wide variety of G-protein-coupled receptors. The ability of Gα15 and Gα16 to bypass the selectivity of receptor G-protein interaction can be a useful tool to understand the mechanism of receptor-induced G-protein activation. In addition, the promiscuous behavior of Gα15 and Gα16 toward receptors may be helpful in finding ligands corresponding to orphan receptors whose signaling properties are unknown.
The effects of the fortificant NaFeEDTA in tofu flour on red blood cell counts in male Sprague-Dawley rats (Rattus norvegicus L.)

The effects of the fortificant NaFeEDTA in tofu flour on red blood cell counts in male Sprague-Dawley rats (Rattus norvegicus L.) were examined. In total, 25 rats were divided into five groups as follows: normal control (NC), which was administered 0.5 % carboxymethyl cellulose (CMC); treatment control (TC), which was administered 0.5 % CMC and unfortified tofu flour; and three treatment groups, which were administered 0.5 % CMC and tofu flour containing 2.7 (T1), 5.4 (T2), or 10.8 mg Fe/kg bw NaFeEDTA (T3). All five groups were treated for 14 consecutive days. Red blood cell counts were measured using an automatic hematology analyzer (Nihon Kohden Celltac α MEK-6450). One-way ANOVA revealed significant effects (P < 0.05) of NaFeEDTA on red blood cell counts in all treatment groups. A least significant difference test illustrated that the red blood cell count was significantly higher (P < 0.05) in the three treatment groups than in the NC and TC groups. The largest increase of the red blood cell count was detected in the T2 group at t14, and the change reflected increases of 22.26 % versus the NC group and 20.24 % versus the TC group.
Cytoskeleton in Pollen and Pollen Tubes of Ginkgo biloba L.

The distribution of F-actin and microtubules was investigated in pollen and pollen tubes of Ginkgo biloba L. using a confocal laser scanning microscope after fluorescence and immunofluorescence labeling. A dense F-actin network was found in hydrated Ginkgo pollen. When Ginkgo pollen was germinating, F-actin mesh was found under the plasma membrane from which the pollen tube would emerge. After pollen germination, F-actin bundles were distributed axially in long pollen tubes of G. biloba. Thick F-actin bundles and network were found in the tip of the Ginkgo pollen tube, which is opposite to the results reported for the pollen tubes of some angiosperms and conifers. In addition, a few circular F-actin bundles were found in Ginkgo pollen tubes. Using immunofluorescence labeling, a dense microtubule network was found in hydrated Ginkgo pollen under confocal microscope. In the Ginkgo pollen tube, the microtubules were distributed along the longitudinal axis and extended to the tip. These results suggest that the cytoskeleton may have an essential role in the germination of Ginkgo pollen and tube growth.
Short communication. Inheritance of cotyledon storage proteins in European sweet chestnut (Castanea sativa Miller)

A first approximation to the inheritance of cotyledon storage proteins was studied in European sweet chestnut (Castanea sativa Mill.) by evaluating the offspring of a controlled cross between two local chestnut varieties ( Corriente and Pilonga ) from southern Spain. The analysis was carried out in 15 polymorphic bands corresponding to the albumin fraction of the storage proteins. The relationship between bands displayed one case of allelism and four of linkage. These results should be considered as the baseline of the genetics of these proteins and suggest that they could be useful for the evaluation of the genetic variability in chestnut.
Natural and synthetic apatites as adsorbents for the removal of azo dyes from aqueous solutions

Hydroxyapatite (HAp) nanorods are synthesized from phosphogypsum waste (PG) and potassium dihydrogen phosphate (KH2PO4) under hydrothermal conditions. The influence of several synthesis parameters such as temperature (100–200 °C), synthesis time (1–15 h), and solution pH (5–11) on product structure and purity is addressed by X-ray diffraction and Fourier Transformed-Infrared Spectroscopy. Phase-pure HAp nanorods with diameter and length of 18 and 63 nm, respectively, are obtained after 10 h at 200 °C and pH∼ 11. The influence of Brij-93 surfactant on the morphology of prepared HAp is investigated by transmission and scanning electron microscopy. The aspect ratio and the mean size of HAp crystals increase to 1013 and 205×20 nm, respectively, with increasing the concentration of Brij-93 surfactant to 0.01 mol. Hence, the PG recycling could be accomplished using an easy synthesis route with relatively cheap reactants for the production of nanocrytalline HAp.
Antioxidative Activity and Lycopene and β-Carotene Contents in Different Cultivars of Tomato (Lycopersicon Esculentum)

Nine different Lycopersicon esculentum varieties were analysed in order to determine differences in the antioxidant activity, both hydrophilic and lipophilic. To assess the nutritional value of all varieties, the total content of principal carotenoids, lycopene, and β-carotene was also analysed. On the basis of analyses performed on all lipophilic fractions, we can affirm that the total antioxidant activity of tomato is due to the integrated action of different compounds instead of that of any single compound such as lycopene and β-carotene. Anticytotoxic activities by brine shrimps assay were also tested on all lipophilic fractions to evaluate potential antitumoral activity.
A new currency for West African states: The theoretical and political conditions of its feasibility

Recent developments in the monetary situation in West Africa, in particular the transformation for the CFA franc area and the project to build a single currency for the CEDEAO/ECOWAS, require a systematic review of the assumptions underlying the formation of monetary unions. The article provides a critical review of the traditional theoretical foundations of optimal currency areas (OCAs) and their subsequent amendments, in light of the problems that emerged in the most relevant monetary unions. On specific points, a comparison is made between the eurozone and the CFA zone. The article then investigates the specific characteristics of the monetary area affected by the reform project, and finally it indicates the main lines along which the project of a common currency to all the states that currently make up the CEDEAO/ECOWAS could evolve, identifying four possible alternative roadmaps. JEL codes : F33, F53, F45
Analysis of the spectrum of a 2x2 operator matrix. Discrete spectrum asymptotics

We consider a 2 × 2 operator matrix Aμ, μ > 0 related with the lattice systems describing two identical bosons and one particle, another nature in interactions, without conservation of the number of particles. We obtain an analog of the Faddeev equation and its symmetric version for the eigenfunctions ofAμ. We describe the new branches of the essential spectrum ofAμ via the spectrum of a family of generalized Friedrichs models. It is established that the essential spectrum of Aμ consists the union of at most three bounded closed intervals and their location is studied. For the critical value μ0 of the coupling constant μ we establish the existence of infinitely many eigenvalues, which are located in the both sides of the essential spectrum ofAμ. In this case, an asymptotic formula for the discrete spectrum ofAμ is found.
Tidal and wind-driven currents in Bass Strait

Preliminary measurements made in Bass Strait on the east Australian shelf indicate large tidal flows but small inertial oscillations. The response of the current to the wind is predominantly along the isobaths while the lower well-mixed layer, which is often separated during the heating season from the wind-mixed layer by a thermocline, appears to respond to the influence of the coast in such a manner as to produce downwelling or upwelling. Bass Strait is a region of complex tidal response and existing co-tidal lines for the eastern area appear to require substantial modification.
Understanding of Feedback Field-Effect Transistor and Its Applications

Feedback field-effect transistors (FBFETs) are devices based on a positive feedback loop in which the electrons and holes in the channel region act on the energy states of the potential barrier and wall. Owing to the positive feedback phenomenon, FBFETs have an excellent subthreshold swing (~0 mV/decade at 300 K), a high on-/off current ratio (~1010), and a clear saturation region. The power consumption of both the turn-on state and turn-off state is significantly low until operation commences. In addition, the hysteresis caused by the carriers accumulated in the potential wall allows the FBFET to act as a memory device. Moreover, the power consumption of neuromorphic devices can be suppressed by ~100 times with the use of FBFETs. In this work, we analyze the device structure and operating principle of the FBFET and summarize its applications.
Preparation of Purified Influenza Virus.∗

Summary While the lability of influenza virus limits the types of chemical and physical procedures to which it can be subjected, several methods are available for the purification of the virus. Either adsorption on calcium phosphate or ultrafiltration through collodion membranes results in preparations free of 90% or more of the nitrogenous material contained in the crude suspensions of infected mouse lungs. When these two techniques are combined, the residual virus recovered is freed of about 99% of the original nitrogen content. The loss of virus activity is only slight and its immunologie properties are apparently unimpaired. Preliminary experiments with the proteo-lytic enzymes, trypsin, chymotrypsin and ribonuclease, indicate their possible use as a further step in the purification of influenza virus. A suspension of virus ultrafiltered after preliminary digestion contained but 1% of the original nitrogen, while the virus was concentrated tenfold.
Corona and financial stability 3.0: Try equity - risk sharing for companies, large and small

This policy letter adds to the current discussion on how to design a program of government assistance for firms hurt by the Coronavirus crisis. While not pretending to provide a cure-all proposal, the advocated scheme could help to bring funding to firms, even small firms, quickly, without increasing their leverage and default risk. The plan combines outright cash transfers to firms with a temporary, elevated corporate profit tax at the firm level as a form of conditional payback. The implied equity-like payment structure has positive risk-sharing features for firms, without impinging on ownership structures. The proposal has to be implemented at the pan-European level to strengthen Euro area resilience.
The effects of kin and familiarity on interactions between fish

Fish have been shown to discriminate between individuals on very general bases such as species, body length and colour. More recently, evidence has been accumulating from a number of species that relatedness and familiarity may be extremely important in mediating a range of interactions between individual fish. Studies have shown that fish are able to recognize kin and/or familiars, and that this ability potentially conveys significant benefits, including increased inclusive fitness, reduced inbreeding costs, reduced competition and enhanced antipredator behaviour. Here, we review the literature and consider future directions and applications for this research.
Ultrastructure of fresh and post thawed sperm of pejerrey Odontesthes bonariensis (Atheriniformes)

In the present study it was showed for the first time the ultrastructural morphology of O. bonariensis sperm using electron microscopy techniques. Different kinds of abnormalities were described in fresh and post thawed sperm caused by crogenic protocols. Pejerrey spermatozoon is uniflagellated and is differentiated into three parts: a small roundish head (~1.80µm in length and 1.67µm in width), a midpiece or transitional region (~1.11µm in length and 1.56µm in width), and a long tail or flagellum (~29.08µm). Samples of fresh and post thawed sperm showed evidence of morphological anomalies affecting various intracellular compartments. Spermatozoa with swollen, ruptured, or absent membranes in the head showing excess of cytoplasm, and with alteration of the spatial orientation of the mitochondria were observed. A swollen flagellum was observed containing cytoplasmic vesicles, distributed along the whole length or concentrated in a restricted part of the tail. It was also found a high level of abnormalities (60%) in frozen sperm when compared with normal sperm (18%) reflecting the damage provoked by cryopreservation procedures.
Variation within the Vaucheria longicaulis complex (Tribophyceae), including previously unknown representatives from the northern Atlantic

Algae resembling Vaucheria longicaulis are recorded for the first time from Massachusetts, England and Portugal. They differ somewhat from the species as conceived at present, and also from one another. The differences are illustrated, discussed and compared with the variation known to occur within V. longicaulis. Knowledge is found to be insufficient at present for the possible separation of new taxonomic entities. Pending more information, all these algae are grouped together as V. longicaulis s. l.
Les huiles de poissons, une ressource à protéger

Each year more than 80 millions of tons of fish are caught in seas and oceans all over the world. 1/3 of the fish are used for the manufacturing of fish oils. Omega-3 from marine sources knows a great success on different markets (food, cosmetics, OTC.) but the natural resources of fish are going to decrease: that would restrict the supplying sources in the future. We need to find other sources: research has been intensified these last years to evaluate consequences of the partial or total replacement of fish oils by vegetable oils. But the problem is the fatty acids content which is not the same. The replacement of fish oils by vegetable oils induces a diminution of omega-3 fatty acids content, which is the characteristic of fish oils (EPA & DHA). Other alternatives to fish oils: marine resources such as micro-algae, genetic manipulation (phytoplankton); reusing of co-products (fish skin, eggs.).
Electrophoretic investigation of systematic relationships in the marine mussels Modiolus modiolus L., Mytilus edulis L., and Mytilus galloprovincialis Lmk. (Mytilidae; Mollusca)

Genetic variation was assayed electrophoretically at 13–16 loci in Modiolus modiolus, Mytilus edulis, and Mytilus galloprovincialis. High genetic distance (D) values were observed between Modiolus modiolus and Mytilus edulis (1.516 ± 0.523) and between Modiolus modiolus and Mytilus galloprovincialis (1.564 ± 0.539), whereas the distance between Mytilus edulis and M. galloprovincialis (0.167 ± 0.118) was rather low. The systematic status ot Mytilus edulis and M. galloprovincialis is discussed in relation to these lindings and the genetic distance values are used to estimate divergence times which in turn are compared with paleontological estimates. The observations of high average heterozygosity in Modiolus modiolus, and high correlations of locus heterozygosity between taxa are discussed briefly.
Reinstatement of Grateloupia subpectinata (Rhodophyta, Halymeniaceae) based on morphology and rbcL sequences

Morphological observations and molecular analyses of the north‐western Pacific species of the red algal genus Grateloupia (Halymeniaceae) indicate the presence of an entity, which is somewhat similar in gross morphology to G. asiatica Kawaguchi et Wang but is distinguished from the latter species by some morphological features. These include: (i) a somewhat fleshy texture; (ii) wider and much thicker (4.5–10 mm wide and up to 1300 μm thick) axes, of which an inner cortex consists of more (6–9) cells; (iii) generally longer (up to 17 cm), marginal and surface proliferations that are clearly constricted (terete) at bases; and (iv) much elongated, oblong auxiliary cells. Phylogenetic analysis using the ribulose‐l,5‐bisphosphate carboxylase/ oxygenase (rbcL) gene of G. asiatica and the alga in question shows them to be distantly related and strongly supports the differentiation of these two entities at the species level. Judging from the literature, this entity is actually Grateloupia subpectinata Holmes, which has been placed into synonymy under G. asiatica [as G. filicina (Lamouroux) C. Agardh] or G. prolongata J. Agardh in previous reports, and therefore the Holmes name is reinstated.
RELATIONSHIP BETWEEN TOTAL QUALITY MANAGEMENT AND ORGANIZATIONAL PERFORMANCE: EMPIRICAL EVIDENCE FROM SELECTED AIRLINES IN NIGERIA AVIATION INDUSTRY

Total Quality Management (TQM) is perceived to be a very important factor for an organization's long-term success and its implementation is an important aspect of increasing operational efficiency. Previous studies of the relationship between TQM and organizational performance (OP) showed inconsistent and contradictory findings. The purpose of this study is to investigate the relationship between TQM and OP: Empirical Evidence from Selected Airlines in Nigeria Aviation Industry. In this study, descriptive research design was utilized and stratified and simple random sampling methods have been used. A close-ended questionnaire was used as the information collection tool on a 5-Likert scale, descriptive statistics were used to analyze the profile of the study participants while Pearson's Correlation was the statistical technique used to evaluate the research hypotheses through the Statistical Package for Social Science (SPSS) version 21. The results indicate that Customer Satisfaction (CS) and Employee satisfaction (ES) that serve as the dimensions of TQM have a favourable connection with OP. Therefore, to make use of these outcomes, it merely implies that organizations need to pay more attention to achieving TQM in terms of products or services by efficiently fulfilling their customers and staff need, as they serve as criteria for OP which ultimately leads to organizational diversification.Keywords: Customer satisfaction, Employee satisfaction, Total Quality Management, Organizational Performance
Critical Review of Literature on Brand Equity and Customer Loyalty

Brand equity is recognized as the driving force of customer loyalty in the competitive firms operating in the changing business environment. The culture of attracting and retaining customers is dependent on which organization can enhance the value of their products to conform and exceed customer needs. By extension, brand equity is regarded as a multi-dimensional facet that comprise of brand loyalty, brand awareness, brand association, perceived quality, brand association and proprietary assets. Theories and models which have been discussed extensively and inform the basis of arguments of this study include; brand equity theory, consumer utility theory, customer based brand equity model, service branding dominant logic model and brand evolution model. Despite conflicting ideologies and evolving nature of brand equity based on psychological aspects of consumers like attitudes and perceptions, it is noted that that there is a positive correlation between brand equity and customer loyalty. Based on the existing literature, it can be concluded that brand equity is the only strategic marketing initiative companies can enhance customer relations and sustainability. Therefore, it is recommended that companies should always strive to enhance their image in the mind of consumers by repositioning their brands in the market.