Miracle-dz/UniFAR-FTUs huggingface dataset:
Orchestrating access to smart city services

Smart cities are poised to provide innovative public services to citizens, communities, corporations, and governmental bodies. Realization and management of these services is assumed to take place centrally, and according to well-defined policies established by city authorities. However, the proliferation of connected devices and crowd-sensing made it possible for ad hoc services to emerge before strict policies and architectures were enforced, and with little provision of interoperability. Furthermore, many existing services in today's cities use networks of privately-owned smart devices, which confine such services to local domains because of ownership and corporate governance. We propose a resource cooperation approach that orchestrates access to connected devices across local domains in order to compose new and potentially large-scale services that are not necessarily bound by local ownership. The resource cooperation approach makes informed recruitment of network segments from local network domains in response to stakeholder queries, which will be posted to a centralized authority responsible for smart city services. Our approach aims at maximizing the utility of city-wide services while maintaining local governance and minimizing performance degradation of service provisioning within local domains. The approach will also facilitate the composition of new smart city services from existing heterogeneous resources, thus minimizing the need to deploy dedicated service infrastructures.
Prevalence of alcohol and other drugs in fatally injured drivers.

AIM This study aims to examine the prevalence of alcohol and/or other drugs (AOD) in a large sample of fatally injured drivers. DESIGN Using data from the Fatality Analysis Reporting System for 2005-09, the authors examined the prevalence of AOD detected in fatally injured drivers in the United States. SETTING Fatal motor vehicle crashes occurring on public roads. PARTICIPANTS Drivers who died within 1 hour of the crash in 14 states that performed toxicological testing on more than 80% of these drivers. MEASUREMENTS The prevalence of AOD and multivariable-adjusted prevalence ratios (aPR). FINDINGS Of the 20,150 fatally injured drivers studied, 57.3% tested positive for AOD, including 19.9% being positive for two or more substances. Alcohol was the most commonly detected substance, present in 40.2% of the fatally injured drivers, followed by cannabinols (10.5%), stimulants (9.0%), narcotics (5.7%) and depressants (4.0%). Multivariable analysis revealed that AOD was significantly more prevalent among drivers who died in single-vehicle crashes [aPR 1.69, 95% confidence interval (CI): 1.62-1.76] or night-time crashes (aPR 1.43, 95% CI: 1.39-1.47), or who had a driving-while-intoxicated conviction within the past 3 years (aPR 1.41, 95% CI: 1.35-1.47), and less prevalent among drivers who were 65 years or older (aPR 0.45, 95% CI: 0.42-0.49), Asian (aPR 0.47, 95% CI 0.41-0.53) or female (aPR 0.88, 95% CI: 0.85-0.91) or who were operating a motor carrier (aPR 0.41, 95% CI 0.34-0.48). CONCLUSIONS More than half of fatally injured drivers in the United States had been using AOD and approximately 20% had been using polydrugs. The prevalence of AOD use varies significantly with driver and crash characteristics.
Multiply-agile encryption in high speed communication networks

Different applications have different security requirements for data privacy, data integrity, and authentication. Encryption is one technique that addresses these requirements. Encryption hardware, designed for use in high-speed communications networks, can satisfy a wide variety of security requirements if that hardware is key-agile, robustness-agile and algorithm-agile. Hence, multiply-agile encryption provides enhanced solutions to the secrecy, interoperability and quality of service issues in high-speed networks. This paper defines these three types of agile encryption. Next, implementation issues are discussed. While single-algorithm, key-agile encryptors exist, robustness-agile and algorithm-agile encryptors are still research topics.
A high voltage power converter with a frequency and voltage controller

A high voltage power converter is presented in this paper and is based on a Capacitor-Diode Voltage Multiplier (CDVM) supplied through an inverter. This power converter has the capabilities of generating variable high DC voltage with improved transient response. The simulation results which are presented in this paper verify that due to its fast transient response, this converter can be used as a high DC voltage source in many applications.
Proteolytic fragmentation of inositol 1,4,5‐trisphosphate receptors: a novel mechanism regulating channel activity?

Inositol 1,4,5‐trisphosphate receptors (IP3Rs) are a family of ubiquitously expressed intracellular Ca2+ release channels. Regulation of channel activity by Ca2+, nucleotides, phosphorylation, protein binding partners and other cellular factors is thought to play a major role in defining the specific spatiotemporal characteristics of intracellular Ca2+ signals. These properties are, in turn, believed pivotal for the selective and specific physiological activation of Ca2+‐dependent effectors. IP3Rs are also substrates for the intracellular cysteine proteases, calpain and caspase. Cleavage of the IP3R has been proposed to play a role in apoptotic cell death by uncoupling regions important for IP3 binding from the channel domain, leaving an unregulated leaky Ca2+ pore. Contrary to this hypothesis, we demonstrate following proteolysis that N‐ and C‐termini of IP3R1 remain associated, presumably through non‐covalent interactions. Further, we show that complementary fragments of IP3R1 assemble into tetrameric structures and retain their ability to be regulated robustly by IP3. While peptide continuity is clearly not necessary for IP3‐gating of the channel, we propose that cleavage of the IP3R peptide chain may alter other important regulatory events to modulate channel activity. In this scenario, stimulation of the cleaved IP3R may support distinct spatiotemporal Ca2+ signals and activation of specific effectors. Notably, in many adaptive physiological events, the non‐apoptotic activities of caspase and calpain are demonstrated to be important, but the substrates of the proteases are poorly defined. We speculate that proteolytic fragmentation may represent a novel form of IP3R regulation, which plays a role in varied adaptive physiological processes.
Oral Immunization of Mice with Lily Pollen Expressing HBsAg

Lily pollen was developed to express HBsAg by Agrobacterium-mediated transformation. A double prime-boost strategy combining parenteral and oral HBsAg boosters was found to increase antibody titer levels 10-fold, as compared to a single process of priming and boosting. Lily pollen may prove a tool for oral vaccine development.
Ethyl (2E,4Z)-5-diethylamino-2-(phenylsulfonyl)penta-2,4-dienoate

In the title compound, C17H23NO4S, the pentadiene group adopts a planar conformation, with an r.m.s. deviation of 0.0410 (14) Å. The phenyl ring makes a dihedral angle of 85.73 (11)° with the pentadiene group, while the pentadiene group makes dihedral angles of 11.38 (11) and 14.08 (10)°, respectively, with the amino and ester groups. In the crystal, molecules are linked via pairs of C—H⋯O interactions, forming inversion dimers.
Effectiveness of a postdischarge care management model for stroke and transient ischemic attack: a randomized trial.

BACKGROUND This randomized controlled trial tested the effectiveness of comprehensive, interdisciplinary postdischarge care management in improving a profile of indicators of health recovery and secondary prevention (profile of health and prevention) in stroke and transient ischemic attack (TIA) patients. METHODS Ninety-six stroke/TIA patients were randomized to usual care or intervention at discharge from our acute stroke unit. The intervention group received an in-home biopsychosocial assessment by an advanced practice nurse at 1 month. A care plan was developed by an interdisciplinary team and implemented in collaboration with the patient's primary care physician. The profile of health and prevention, measured at 3 months, was comprised of 5 domains: (1) Neuromotor Function, (2) Severe Complications, (3) Quality of Life, (4) Management of Risk for common poststroke complications and recurrent stroke, and (5) Stroke Knowledge. A single global hypothesis test across multiple end points was used to compare the 2 groups. RESULTS The intervention significantly improved the profile of health and prevention (P < .0001). In addition, each domain showed a positive effect of the intervention. Effect sizes (in standard deviation units) of the intervention on domains were . 1 for Neuromotor Function (90% confidence interval [CI] = -.3 to .5); . 4 for Severe Complications (90% CI = .1 to .8); . 5 for Quality of Life (90% CI = .1 to .9); . 6 for Management of Risk for common poststroke complications and recurrent stroke (90% CI = .3 to 1.); and 1.0 for Stroke Knowledge (90% CI = .6 to 1.4). CONCLUSIONS This model of care management resulted in a significantly better profile of health and prevention for stroke/TIA patients 3 months postdischarge.
Lack of association between calf morbidity and subsequent first lactation milk production in 25 New York Holstein herds.

The association of owner-diagnosed calfhood diseases with first lactation milk production was evaluated using data collected prospectively for 728 heifers from 25 New York dairy herds. Cows diagnosed with one or more occurrences of dullness, respiratory disease, or scours within 90 d of birth had first lactation milk production that was similar to that of unaffected herdmates. Estimates for the effects of dullness, respiratory disease, and scours on second test milk production were -1.0, 1.0, and . 4 kg/d, respectively (adjusted for season and age at calving, times milked per day, study month on birth, sire PTA for milk production, and the other two calfhood diseases). Estimates for the effects on 305-day mature equivalent production were -139, 123, and 158 kg for dullness, respiratory disease, and scours, respectively (adjusted for study month of birth, sire PTA for milk production, and the other two calfhood diseases). These results were based on data of heifers that were selected as replacements and remained in the herd long enough to have milk production recorded. There was no significant detrimental effect of owner-diagnosed calfhood disease on first lactation milk production, but affected heifers had higher mortality before calving and were less likely to enter the milking herd.
Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus

Background: Patients with concomitant diabetes mellitus (DM) and prior stroke (PS) were excluded from European approval of alteplase in stroke. We examined the influence of DM and PS on the outcomes of patients who received thrombolytic therapy (T; data from Safe Implementation of Thrombolysis in Stroke–International Stroke Thrombolysis Register) compared to nonthrombolyzed controls (C; data from Virtual International Stroke Trials Archive). Methods: We selected ischemic stroke patients on whom we held data on age, baseline NIH Stroke Scale score (NIHSS), and 90-day modified Rankin Scale score (mRS). We compared the distribution of mRS between T and C by Cochran-Mantel-Haenszel (CMH) test and proportional odds logistic regression, after adjustment for age and baseline NIHSS, in patients with and without DM, PS, or the combination. We report odds ratios (OR) for improved distribution of mRS with 95% confidence interval (CI) and CMH p value. Results: Data were available for 29,500 patients: 5,411 (18.5%) had DM, 5,019 had PS (17.1%), and 1,141 (5.5%) had both. Adjusted mRS outcomes were better for T vs C among patients with DM (OR 1.45 [1.30–1.62], n = 5,354), PS (OR 1.55 [1.40–1.72], n = 4,986), or concomitant DM and PS (OR 1.23 [0.996–1.52], p = 0.05, n = 1,136), all CMH p < 0.0001. These are comparable to outcomes between T and C among patients with neither DM nor PS: OR = 1.53 (1.42–1.63), p < 0.0001, n = 19,339. There was no interaction on outcome between DM and PS with alteplase treatment (tissue plasminogen activator × DM × PS, p = 0.5). Age ≤80 years or >80 years did not influence our findings. Conclusions: Outcomes from thrombolysis are better than the controls among patients with DM, PS, or both. We find no statistical justification for the exclusion of these patients from receiving thrombolytic therapy.
Introduction: Intellectual capital: the future of business navigation

In May 2007, our Centre for Research in Intellectual Capital hosted the International Congress on Intellectual Capital: The future of business navigation. The Congress – which took place in Haarlem, The Netherlands – was attended by more than 140 participants from 23 countries. Based on almost 70 papers, we designed a conference program that consisted of more than 90 sessions. This special issue is based on a selection of the best papers of our conference.
Application of SVM and Fuzzy Set Theory for Classifying with Incomplete Survey Data

Classification with incomplete survey data is a new subject, and also which is an important theme in data mining. This paper proposes a novel, powerful classification machine, support vector machine (SVM) based model of classification for incomplete survey data. Using this model, an incomplete survey data is translated to fuzzy patterns without missing values firstly, and then used these fuzzy patterns as the exemplar set for teaching the support vector machine. Experimental results from the real-world data verify the effectiveness and applicability of the proposed model. Compared with other classification techniques, the method can utilize more information provided by the data, and reveal the risk of the classification result.
Feeding value of crambe press cake and extracted meal as well as production responses of growing-finishing pigs and dairy cows fed these by-products

To analyse the feeding value of crambe press cake (CPC) and crambe extracted meal (CEM), and the incorporation limits in pig diets, a series of balance trials with a total of 12 male castrates was conducted. Additionally, in a feeding trial the effect of 5 % and 10 % CPC or CEM on growth performance and on pork quality was tested. The CP content of CPC and CEM was 207 and 331 g/kg DM, respectively, and the residual EE 144 and 26 g/kg DM, respectively. The erucic acid concentration amounted to 56 % of total fatty acids. Glucosinolate contents were found to be 50 mmol/kg CPC-DM and 70 mmol/kg CEM-DM. The digestibility of OM was 54 % for both by-products and the ME contents were 10.6 and 9.3 MJ/kg DM for CPC and CEM, respectively. In the feeding trial, 10 % CPC in the diet significantly decreased BWG from 782 g/d (controls) to 742 g/d. Due to glucosinolate intake, the weight of liver, thyroid glands and kidneys was significantly increased. The body fat showed an increased deposition of erucic acid in back fat and intramuscular fat, but changes in sensory properties of the meat were not detected. It is recommended that the incorporation rate of CPC and CEM in diets for growing-finishing pigs should not exceed 5 %. The balance experiments, carried out with four wethers each, showed that the OM of CPC and CEM was better digested by ruminants, amounting to 71% or 67%, respectively. The energy content amounted to 7.4 and 6.0 MJ NEL/ kg DM, respectively. In the feeding trials with lactating cows, 30 % CPC or CEM in the concentrate resulted in a decrease of concentrate intake of about 7%. Due to the high residual fat content of CPC, the milk fat content decreased and the erucic acid content increased. The high glucosinolate intake affected the iodine concentration in the milk. CPC and CEM feeding decreased the iodine content from 271 – 117 μg/kg and from 182 – 77 μg, respectively. It is recommended that crambe by-products should not exceed 15 % in concentrates or an intake of 1 kg/d for dairy cows.
Identification of Acute Phase Proteins and Assays Applicable in Nondomesticated Mammals

Abstract The serum concentration of acute phase proteins (APPs) increases dramatically in response to inflammation and tissue injury. APPs are clinically useful in a range of domesticated mammals; however, knowledge is limited in nondomesticated mammals. The detective ability of two assays for each of three potential APPs—serum amyloid A (SAA), C-reactive protein (CRP), and haptoglobin (Hp)—was evaluated in eight species. For SAA, a turbidimetric immunoassay (TIA) demonstrated significant detective abilities in the Asian elephant (Elaphas maximus), impala (Aepyceros melampus), musk ox (Ovibos moschatus), and chimpanzee (Pan troglodytes), as did an SAA enzyme-linked immunosorbent assay (ELISA) in the impala. For CRP, both TIA and ELISA had significant detective abilities in the chimpanzee. For Hp, a colorimetric assay demonstrated significant detective abilities in impala, musk ox, sitatunga (Tragelaphus spekeii), and chimpanzee, as did the Hp ELISA in the impala, musk ox, and sitatunga. In conclusion, these results suggest that assays for detection of relevant APPs in several nondomesticated animals are available.
Integrative neurohumoural regulation of oxytocin neurone activity in pregnancy and lactation

Oxytocin is required for normal birth and lactation. Oxytocin is synthesised by hypothalamic supraoptic and paraventricular nuclei neurones and is released into the circulation from the posterior pituitary gland. Under basal conditions, circulating oxytocin levels are relatively constant but, during birth and lactation, pulsatile oxytocin release triggers rhythmic contraction of the uterus during birth and milk ejection during suckling. Oxytocin levels are principally determined by the pattern of action potential firing, which, in turn, is determined by the interplay between the intrinsic properties of the oxytocin neurones and the regulation of their excitability by surrounding glia, as well as by synaptic drive from their afferent inputs. During birth and suckling, oxytocin neurones fire high‐frequency bursts of action potentials that are coordinated across the population of neurones. These bursts underpin the pulsatile secretion of oxytocin required for normal birth and lactation. Neuroglial regulation of oxytocin neurones changes during pregnancy to favour burst firing. However, these changes still require afferent input activity to drive activity. Although it has long been known that noradrenergic inputs to oxytocin neurones are activated during birth and lactation, the involvement of other afferent inputs is less clear. Here, we provide a brief overview of the current understanding of the mechanisms that regulate oxytocin neurone activity during pregnancy and lactation, and also focus on recent evidence from our laboratory identifying an input that increases kisspeptin production to excite oxytocin neurones in late pregnancy.
Acute Otitis Media in Children: Bacteriological Findings in Middle Ear Fluid Obtained by Needle Aspiration

ACUTE otitis media presents one of the most frequent and perplexing infectious disease problems facing the pediatrician. Therapy is usually empirical, since cultures of the nose and throat, when done, reflect the causative agent only imperfectly.1,2Therefore, the present study was carried out in children with acute otitis media and bulging tympanic membranes in order to determine whether needle aspiration of fluid from the middle ear would provide more direct and reliable information about the causative organisms. The bacteriological results of cultures of the aspirated fluids and comparisons with those of the throat and nasopharynx are presented in this paper. The results of attempts to isolate viruses andMycoplasmafrom these aspirated fluids are to be reported separately.3 Patients, Materials, and Methods A total of 90 children, seen at the Boston City Hospital between July 1964 and April 1965, who presented the clinical features of acute otitis media
Analysis on the Causes for Sino-US Trade Imbalance

The United States triggered a new pressure wave on RMB appreciation and voiced criticism that Chinese government wanted to manipulate exchange rate to gain unfair competitive advantage in international trade.Such unjustified criticisms did nothing but deteriorate the imbalance of Sino-US trade and do harm to the American economy.As a matter of fact,the RMB appreciation will neither resolve the American balance of payments nor reduce the rate of unemployment in America.The fundamental matter of Sino-US trade imbalance lies in the international division of economy and the Sino-US difference of saving rate.The RMB exchange rate is not responsible for the Sino-US trade deficit,and RMB appreciation is not a remedy for the American economy.
Bullwhip effect and synthetic compensation in multi-echelon tree-type supply chain

The bullwhip effect and compensation of a multi-echelon tree-type supply chain were discussed to improve actual operation efficiency of supply chain.A series of quantitative index of bullwhip effect was provided,by which,impacts of multi-echelon tree-type topology structure,competition,information transformation,lead time,distribution,prediction on bullwhip were studied.Then the compensation methods for information transformation,leading time and distribution strategy were established,together with a fuzzy switch-cut synthetic compensator was designed combining with the metrics of normal compensator and fuzzy one.The whole compensation process under stochastic demand,competition,promotion and flying goods in tree-type supply chain was simulated,and effectiveness of the proposed compensation scheme was finally verified.
TRPC1, TRPC3, and TRPC4 in Rat Orofacial Structures

TRPC (transient receptor potential cation channel subfamily C) members are nonselective monovalent cation channels and control Ca2+ inflow. In this study, immunohistochemistry for TRPC1, TRPC3, and TRPC4 was performed on rat oral and craniofacial structures to elucidate their distribution and function in the peripheries. In the trigeminal ganglion (TG), 56.1, 84.1, and 68.3% of sensory neurons were immunoreactive (IR) for TRPC1, TRPC3, and TRPC4, respectively. A double immunofluorescence method revealed that small to medium-sized TG neurons co-expressed TRPCs and calcitonin gene-related peptide. In the superior cervical ganglion, all sympathetic neurons showed TRPC1 and TRPC3 immunoreactivity. Parasympathetic neurons in the submandibular ganglion, tongue, and parotid gland were TRPC1, TRPC3, and TRPC4 IR. Gustatory and olfactory cells were also IR for TRPC1, TRPC3, and/or TRPC4. In the musculature, motor endplates expressed TRPC1 and TRPC4 immunoreactivity. It is likely that TRPCs are associated with sensory, autonomic, and motor functions in oral and craniofacial structures.