Miracle-dz/UniFAR-FTUs huggingface dataset:
A multicenter, open-label phase II trial of dovitinib, a fibroblast growth factor receptor 1 (FGFR1) inhibitor, in FGFR1-amplified and nonamplified metastatic breast cancer (BC).

289 Background: Amplification of the FGFR1 gene occurs in ≈ 10% of BC, correlates with FGFR1 overexpression, and is mainly observed in estrogen receptor (ER)-positive human epidermal growth factor receptor 2 (HER2)- BCs. Dovitinib (TKI258) is a multitargeted tyrosine kinase inhibitor that demonstrated potent antitumor activities in FGFR1-amplified tumor cell lines. This phase 2 study evaluated the efficacy and safety of dovitinib in metastatic HER2- BC. METHODS Patients were stratified into 4 groups based on FGFR1 and hormone receptor (HR) tumor subtype: 1) FGFR1+, HR+; 2) FGFR1+, HR-; 3) FGFR1-, HR+; 4) FGFR1-, HR-. Screening for FGFR1 status was performed by fluorescence/chromogenic in situ hybridization (cutoff ≥ 6 gene copies). Dovitinib (500 mg) was administered once daily on a 5-day-on/ 2-day-off schedule. The primary endpoint was RECIST best overall response rate in patients with measurable disease per external radiology review. RESULTS Data from 77 of 81 treated patients were available as of January 2011 (n=21, n=34, n=22 in groups 1, 3, 4, respectively). Median number of prior therapies in the metastatic setting was 2 chemotherapy lines (all patients) and 2 endocrine therapy lines (HR+ patients). Liver metastases were present in 58% of patients (81%, 50%, 50% in groups 1, 3, 4, respectively). Most common adverse events included vomiting (75%; grade 3 [g3]: 6%), diarrhea (72%; g3: 6%), nausea (62%; g3: 5%), and asthenia (61%; g3: 17%). Median dovitinib exposure was 1.7 (range, 0-8.2) months, including 8 patients with > 4 months of therapy. Of patients with measurable disease at baseline, in group 1, 13% had unconfirmed partial responses and 44% had stable disease ≥ 4 months (SD4). In groups 3 and 4, 29% and 11% had SD4. CONCLUSIONS This is the first trial reporting efficacy of an FGFR1 inhibitor in patients with FGFR1-amplified BC. Dovitinib showed antitumor activity in patients with HR+, FGFR1- amplified BC and disease stabilization in other subgroups. FGFR1 is likely a relevant target in BC, and FGFR1 amplification may define a segment of dovitinib-sensitive disease. Further evaluation of dovitinib in patients with HR+ BC is planned.
A second human methionine sulfoxide reductase (hMSRB2) reducing methionine-R-sulfoxide displays a tissue expression pattern distinct from hMSRB1

Abstract Peptide methionine sulfoxide reductases are important enzymes in the defense against cellular oxidative stress as they reduce methionine sulfoxide, the product of methionine oxidation by physiologically relevant reactive oxygen species. Two distinct enzyme classes, MSRA and MSRB, have evolved for selectively reducing the two epimers, methionine-S-sulfoxide and methionine-Rsulfoxide. A new human MSR enzyme (hMSRB2) specifically reducing methionine-R-sulfoxide, which showed a conversion rate for peptide-bound methionine-S-sulfoxide similar to hMSRB1, was characterized with respect to its tissue expression. As previously found for hMSRB1, expression of hMSRB2 mRNA was weak in brain, but strong in heart and skeletal muscle. In contrast to hMSRB1, its expression was high in smooth muscle-containing organs (digestive system, bladder), lung and aorta, while hMSRB1 displayed a higher expression than hMSRB2 in liver and kidney.
Intramedullary Infections Treated With Antibiotic Cement Rods: Preliminary Results in Nine Cases

The treatment of intramedullary infections after nailing usually includes removal of the rod, debridement of the canal, and, in many cases, insertion of antibiotic-impregnated cement beads. These beads offer no mechanical support and are difficult to remove if left in place for more than 2 weeks. We present an alternative for filling the medullary canal's noncollapsible dead space with an antibiotic-impregnated cement rod. This rod can be custom-made at the time of surgery, using different diameter chest tubes as molds and embedding a 3-mm beaded guidewire within the cement. The smooth molded surface of this nail makes extraction of the cement rod relatively easy. The cement rod also provides some limited temporary support to the fracture or nonunion site while the infection is being treated. After 6 weeks, the rod can be removed and replaced with a definitive metal intramedullary nail, with or without bone grafting to treat the previously infected fracture or nonunion site. We retrospectively reviewed nine cases of intramedullary infection treated with antibiotic-impregnated molded cement rods. These included six femora, two tibiae, and one humerus. The cause of infection was lengthening or transport over nail in six cases, fixator-augmented nailing of osteotomies in two, and fracture fixation in one. The follow-up period after surgery ranged from 38 to 48 months. No recurrent infection occurred during this follow-up period, and no patient required antibiotics after the rod was removed. In all cases, the canal cultures were negative after rod removal. The cement rod was removed between 29 and 753 days after implantation. Fracture of the rod occurred in one case in which the rod was left in place for more than 1 year. We conclude that this method is a relatively simple and inexpensive alternative for the treatment of intramedullary infections.
Sustained reduction in bronchial hyperresponsiveness with inhaled fluticasone propionate within three days in mild asthma: time course after onset and cessation of treatment

Background: Bronchial hyperresponsiveness (BHR) is characteristic of asthmatic airways, is induced by airway inflammation, and is reduced by inhaled corticosteroids (ICS). The time course for the onset and cessation of the effect of ICS on BHR is unclear. The effect of inhaled fluticasone propionate (FP) on BHR in patients with mild persistent asthma was assessed using time intervals of hours, days and weeks. Methods: Twenty six asthmatic patients aged 21–59 years were selected for this randomised, double blind, parallel group study. The effect of 250 μg inhaled FP (MDI) administered twice daily was compared with that of placebo on BHR assessed using a dosimetric histamine challenge method. The dose of histamine inducing a decrease in forced expiratory volume in 1 second (FEV1) by 15% (PD15FEV1) was measured before and 6, 12, 24 and 72 hours, and 2, 4 and 6 weeks after starting treatment, and 48 hours, 1 week and 2 weeks after cessation of treatment. Doubling doses of changes in PD15FEV1 were calculated and area under the curve (AUC) statistics were used to summarise the information from individual response curves. Results: The increase in PD15FEV1 from baseline was greater in the FP group than in the placebo group; the difference achieved significance within 72 hours and remained significant until the end of treatment. In the FP group PD15FEV1 was 1.85–2.07 doubling doses above baseline between 72 hours and 6 weeks after starting treatment. BHR increased significantly within 2 weeks after cessation of FP treatment. Conclusions: A sustained reduction in BHR to histamine in patients with mild asthma was achieved within 3 days of starting treatment with FP at a daily dose of 500 μg. The effect tapered within 2 weeks of cessation of treatment.
AUS DEM LEHRSTUHL FÜR AUGENHEILKUNDE PROF. DR. HORST HELBIG DER FAKULTÄT FÜR MEDIZIN DER UNIVERSITÄT REGENSBURG KOMPLIKATIONSRATE UND RISIKOFAKTOREN FÜR INTRAOPERATIVE KOMPLIKATIONEN BEI PHAKOEMULSIFIKATIONEN VON OPERATEUREN AM ANFANG IHRER AUSBILDUNG Inaugural – Dissertation zur Erlangung des 

Background/Aim To determine the complication rate and risk factors for intraoperative complications in residentperformed phacoemulsification surgery at a tertiary care center during the first 100 surgeries. Methods Retrospective chart review of the first 100 performed phacoemulsification cases of six consecutive residents. Posterior capsule tear, vitreous loss, and dislocation of lenticular fragments into the vitreous were defined as intraoperative complications. Patient characteristics considered risk factors for surgery were identified and correlated with the occurrence of intraoperative complications. Results Complications occurred in 23 of 600 operations (3.8 %). Surgery was complicated by posterior capsular tear in 23 eyes (3.8 %) with vitreous loss in 17 eyes (2.8 %) and loss of lenticular fragments into the vitreous in seven eyes (1.2 %). Eyes with dense nuclear sclerosis (p00.002) and white cataracts (p00.019) were associated with a statistically significantly greater incidence of posterior capsular tears and vitreous loss (p00.007 and p00.027 respectively). An intraocular lens was implanted in 591 eyes as intended. Conclusions Residents achieve an acceptable complication rate during their initial 100 phacoemulsification cases.
Ageing and collapse in gels with long-range attractions

We report measurements on the ageing dynamics of a colloid–polymer mixture with a large polymer–colloid size ratio of 0.62. Quenched into a two-phase region the system gels and forms a network with a characteristic radius Rc. We find three distinct regimes in the time evolution of Rc(t), reminiscent of the linear, late and gravity-dominated regimes of coarsening seen in classical spinodal decomposition kinetics of binary fluids. In the early stages of gelation, we observe a peak in the time-dependent structure factor S(q, t) which is stationary in q and grows in intensity characteristic of a linear-Cahn regime. The domain size then coarsens continuously with the age t of the sample. In the late stages the domain size follows the approximate algebraic law, Rc ∼ tθ. The growth exponent θ is a strong function of the quench depth: for small polymer concentrations θ is significantly larger than for large polymer concentrations. The gel networks formed are transient, and in the final stages of phase separation, collapse under gravity when the correlation length of the gel becomes ∼ 2π times the capillary length.
Plate-tectonic evolution of the Earth: bottom-up and top-down mantle circulation

Intense devolatilization and chemical-density differentiation attended accretion of planetesimals on the primordial Earth. These processes gradually abated after cooling and solidification of an early magma ocean. By 4.3 or 4.2 Ga, water oceans were present, so surface temperatures had fallen far below low-pressure solidi of dry peridotite, basalt, and granite, ∼1300, ∼1120, and ∼950 °C, respectively. At less than half their T solidi, rocky materials existed as thin lithospheric slabs in the near-surface Hadean Earth. Stagnant-lid convection may have occurred initially but was at least episodically overwhelmed by subduction because effective, massive heat transfer necessitated vigorous mantle overturn in the early, hot planet. Bottom-up mantle convection, including voluminous plume ascent, efficiently rid the Earth of deep-seated heat. It declined over time as cooling and top-down lithospheric sinking increased. Thickening and both lateral extensional + contractional deformation typified the post-Hadean l.
The Circulating MicroRNA-206 Level Predicts the Severity of Pulmonary Hypertension in Patients with Left Heart Diseases

Background: MicroRNA-206 (miR-206), a muscle-specific miRNA, regulates the growth of cardiac myocytes and pulmonary artery smooth muscle cells. However, it remains unknown whether miR-206 is involved in pulmonary hypertension (PH) due to left heart diseases (PH-LHD). This study was designed to investigate the correlation between miR-206 and PH in patients with LHD. Methods: In 82 consecutively enrolled LHD patients, we examined the serum levels of miR-206 and analyzed its correlations with pulmonary artery systolic pressure (PASP) and cardiac function. Another 36 age- and sex-matched subjects served as healthy controls. Results: The patients were divided into the LHD group (n=47, PASP<50 mmHg) and the PH-LHD group (n=35, PASP≥50 mmHg). The level of miR-206 was significantly decreased in the PH-LHD group compared with that of the LHD and healthy control groups. In addition, the miR-206 level was correlated with PASP (r=-0.305, p<0.001) but not with systemic blood pressure. Univariate analyses showed that miR-206, brain natriuretic peptide (BNP), left ventricular ejection fraction and left atrial longitudinal diameter (LAD) were significantly related to PASP. Multivariate regression analysis identified miR-206 as an independent predictive factor for PH. MiR-206 alone (cut-off <0.66) demonstrated a sensitivity of 68.60% and a specificity of 65.80% in predicting PH. Moreover, the combination of miR-206, BNP and LAD (cut-off 0.21) showed a sensitivity of 97.10% and a specificity of 80.30% in predicting PH in LHD patients. Conclusion: A decreased circulating miR-206 level was associated with increased PASP in LHD patients. Thus, the level of miR-206, especially combined with BNP and LAD, might be helpful in the detection of PH in LHD patients.
Periodontal Disease as a Specific, albeit Chronic, Infection: Diagnosis and Treatment

SUMMARY Periodontal disease is perhaps the most common chronic infection in adults. Evidence has been accumulating for the past 30 years which indicates that almost all forms of periodontal disease are chronic but specific bacterial infections due to the overgrowth in the dental plaque of a finite number of mostly anaerobic species such as Porphyromonas gingivalis, Bacteroides forsythus, and Treponema denticola. The success of traditional debridement procedures and/or antimicrobial agents in improving periodontal health can be associated with the reduction in levels of these anaerobes in the dental plaque. These findings suggest that patients and clinicians have a choice in the treatment of this overgrowth, either a debridement and surgery approach or a debridement and antimicrobial treatment approach. However, the antimicrobial approach, while supported by a wealth of scientific evidence, goes contrary to centuries of dental teaching that states that periodontal disease results from a “dirty mouth. ” If periodontal disease is demonstrated to be a risk factor for cardiovascular disease and stroke, it will be a modifiable risk factor since periodontal disease can be prevented and treated. Since the antimicrobial approach may be as effective as a surgical approach in the restoration and maintenance of a periodontally healthy dentition, this would give a cardiac or stroke patient and his or her physician a choice in the implementation of treatment seeking to improve the patient's periodontal condition so as to reduce and/or delay future cardiovascular events.
Tor1, Sch9 and PKA downregulation in quiescence rely on Mtl1 to preserve mitochondrial integrity and cell survival

Here we show that Mtl1, member of the cell wall integrity pathway of Saccharomyces cerevisiae, plays a positive role in chronological life span (CLS). The absence of Mtl1 shortens CLS and causes impairment in the mitochondrial function. This is reflected in a descent in oxygen consumption during the postdiauxic state, an increase in the uncoupled respiration and mitochondrial membrane potential and also a descent in aconitase activity. We demonstrate that all these effects are a consequence of signalling defects suppressed by TOR1 (target of rapamycin) and SCH9 deletion and less efficiently by Protein kinase A (PKA) inactivation. Mtl1 also plays a role in the regulation of both Bcy1 stability and phosphorylation, mainly in response to glucose depletion. In postdiauxic phase and in conditions of glucose depletion, Mtl1 negatively regulates TOR1 function leading to Sch9 inactivation and Bcy1 phosphorylation converging in PKA inhibition. Slt2/Mpk1 kinase partially contributes to Bcy1 phosphorylation, although additional targets are not excluded. Mtl1 links mitochondrial dysfunction with TOR and PKA pathways in quiescence, glucose being the main signalling molecule.
Pour une dendrométrie fonctionnelle : essai sur l'intégration de connaissances écophysiologiques dans les modèles de production ligneuse

L'objectif de ce travail etait d'enrichir quelques modeles forestiers elastiques, dits dendrometriques, a l'aide de la connaissance de processus physiologiques, pour mieux prendre en compte des variables environnementales et leur variation dans le temps. Cette demarche s'integre donc dans la modelisation a base eco-physiologique. Celle-ci necessite a la fois un tour d'horizon des processus physiologiques connus et quantifies, le choix de leur prise en compte, ou non en fonction des objectifs du modele et enfin leur formalisation et integration dans un modele global de croissance. Elle est actuellement bien developpee pour les plantes et il s'agissait de prendre en compte le caractere particulier de la croissance secondaire chez les arbres. Le modele biologique choisi etait l'epicea commun en peuplement equienne monospecifique
Partitioning Surfaces Into Quadrilateral Patches: A Survey

The efficient and practical representation and processing of geometrically or topologically complex shapes often demands a partitioning into simpler patches. Possibilities range from unstructured arrangements of arbitrarily shaped patches on the one end, to highly structured conforming networks of all‐quadrilateral patches on the other end of the spectrum. Due to its regularity, this latter extreme of conforming partitions with quadrilateral patches, called quad layouts, is most beneficial in many application scenarios, for instance enabling the use of tensor‐product representations based on splines or Bézier patches, grid‐based multi‐resolution techniques and discrete pixel‐based map representations. However, this type of partition is also most complicated to create due to the strict inherent structural restrictions. Traditionally often performed manually in a tedious and demanding process, research in computer graphics and geometry processing has led to a number of computer‐assisted, semi‐automatic, as well as fully automatic approaches to address this problem more efficiently. This survey provides a detailed discussion of this range of methods, treats their strengths and weaknesses and outlines open problems in this field of research.
Protease inhibitors are associated with a slowed progression of HIV-related renal diseases.

AIMS While angiotensin-con-verting enzyme inhibitors and zidovudine may improve the course of the most common HIV-related renal disease, HIV-associated nephropathy (HIVAN), the effect of anti-retroviral combination therapy on this and other HIV-related renal diseases has not been assessed. This study describes the clinical course of HIV-related renal diseases and the effect of protease inhibitors on their progression. METHODS This retrospective cohort study reviews the clinical course of 19 patients with a clinical or biopsy-proven diagnosis of HIVAN or other HIV-related renal diseases. Groups progressing and not progressing to ESRD were compared using longitudinal analyses to assess the association between creatinine clearance and clinical and therapeutic factors. RESULTS The cohort consisted of 16 African-Americans, 2 Caucasians and 1 Native American. Their modes of HIV infection were intravenous drug use (7), a history of men having sex with men (3) and heterosexual behavior (5). Patients were followed for a median of 16.6 months. Seven patients reached ESRD. Loss of creatinine clearance over time did not differ among genders, races, or patients with different modes of HIV infection. Longitudinal analyses demonstrated an association between protease inhibitors and prednisone and a slower decline in creatinine clearance in multivariable models (p = 0.04 and 0.003, respectively). CONCLUSIONS The epidemiology and clinical course of HIV-related renal diseases is more heterogeneous than previously described. This study suggests a benefit to the use of protease inhibitors and prednisone on the progression of these nephropathies.
MOTIVAÇÃO NO TRABALHO: AVALIANDO O AMBIENTE ORGANIZACIONAL

Resumo Este artigo tem por objetivo avaliar o ambiente organizacional de uma Superintendência da Polícia Federal na região norte, visando analisar suas características em relação à motivação dos Agentes de Polícia Federal no trabalho, além de diagnosticar o grau de motivação no trabalho do universo pesquisado. O estudo utilizou como referencial teórico a teoria higiene-motivacional de atitudes no trabalho, desenvolvida por Frederick Herzberg. Trata-se de uma pesquisa de cunho quantitativo, onde foram entrevistados os Agentes de Polícia Federal, lotados e em exercício nas Delegacias e Núcleos subordinados à Delegacia Regional Executiva. A pesquisa desenvolvida teve por finalidade responder a duas perguntas principais: O ambiente organizacional das delegacias e núcleos que compõem a Delegacia Regional Executiva desta Superintendência oferece condições favoráveis ao desenvolvimento da motivação no trabalho? Os Agentes de Polícia Federal, lotados e em exercício nesta Delegacia Regional Executiva, encontram-se motivados no trabalho? Os resultados auferidos pela pesquisa apontam para o fato de que o ambiente organizacional não oferece condições propícias ao desenvolvimento da motivação no trabalho. Além disso, a grande maioria dos Agentes de Polícia Federal pesquisados não se considera motivada no trabalho.
The comparision of some properties for various digital CNN

Our contribution paper deals with comparison of the new architecture of CNN with another two digital networks. The most area on a chip occupy multipliers, therefore we proposed CNN network, where multiplication in the input with weight is realized by AND block , while multiplied signal is special distributed in the time. All the designed networks are digital and we compare the parameters as the speed and chip area consumption. From the comparison we can recognize that our proposed digital CNN network is the best from the other ones.
Suicide-Related Concerns as a Mediator Between Physical Abuse and Self-Harm Behaviors in College Students.

BACKGROUND Multiple studies have found correlations between history of abuse and self-harm behaviors, but few have examined potential mediators. Studying suicide-related concerns as a mediator in this relationship could inform the interpersonal theory of suicide by identifying acquired capability as a necessary component in self-harm behavior. AIMS This study examined the link between childhood physical abuse, self-injurious behaviors, and suicide-related concerns in young adults. It was hypothesized that more physical abuse and fewer suicide-related concerns would predict self-harm behaviors, and that suicide-related concerns would mediate this relationship. METHOD A sample of 212 university students completed self-report measures that assessed self-harm behavior history, reasons for living, and childhood physical abuse. RESULTS Results supported the hypothesis that more instances of abuse and less concern about pain and death were significantly associated with greater self-harm history. Suicide-related concerns also mediated the relationship between physical abuse and self-harm behaviors. CONCLUSION These results support recent theories that habituation to painful and provocative events is an important mechanism in explaining why people engage in self-injurious acts, and provides initial evidence for cognitive mediators between physical abuse and self-harm.