Miracle-dz/UniFAR-FTUs huggingface dataset:
Impacto de la asistencia a una piscina con agua clorada sobre la salud respiratoria de los adolescentes

Objetivo: Estimar la carga de enfermedades alérgicas asociada con la exposición de los adolescentes a piscinas cloradas. Métodos: Examinamos a 847 estudiantes, de 13 a 18 años de edad, que habían asistido a piscinas cloradas, cubiertas o descubiertas, con distintas frecuencias. De ellos, 114 habían asistido principalmente a una piscina con cobre y plata y sirvieron de grupo de referencia. Medimos las concentraciones séricas de inmunoglobulina E (IgE) total y específica de aeroalergeno y estudiamos sistemáticamente la constricción bronquial inducida por el esfuerzo. Los resultados fueron los síntomas respiratorios, la fiebre del heno, la rinitis alérgica y el asma diagnosticado en cualquier momento (asma en algún momento) que estaba en tratamiento con medicamentos, se asociaba con una constricción bronquial inducida por el esfuerzo, o ambas situaciones (asma actual). Resultados: Entre los adolescentes con atopia y concentraciones séricas de IgE > 30 kUI/l o de IgE específica de aeroalergeno, la razón de posibilidades (odds ratio) de síntomas de asma y de asma en algún momento o actual aumentó con el número de horas pasadas en piscinas cloradas durante la vida, alcanzando valores de 7,1 a 14,9 cuando la asistencia a piscinas cloradas superó las 1.000 h. Los adolescentes con atopia y asistencia a piscinas cloradas > 100 h mostraron mayor riesgo de fiebre del heno (OR: 3,3-6,6), y los que asistieron > 1.000 h tuvieron mayor riesgo de rinitis alérgica (OR: 2,2-3,5). Estas asociaciones no se encontraron entre los adolescentes sin atopia o los que asistieron a piscinas con cobre y plata. Los riesgos atribuibles a la población de asma diagnosticada en algún momento, fiebre del heno y rinitis alérgica relacionadas con una piscina clorada fueron 63,4%, 62,1% y 35,0%, respectivamente. Conclusión: La exposición a una piscina clorada ejerce un efecto adyuvante sobre la atopia que parece contribuir de forma significativa a la carga de asma y alergias respiratorias entre los adolescentes.
On the Edge: Children and Families Displaced by Hurricanes Katrina andRita Face a Looming Medical and Mental Health Crisis: Executive Summary

The individuals and families who were displaced by Hurricanes Katrina and Rita and who have ended up in FEMA-subsidized community housing in Louisiana are facing a second crisis, one in which untreated and undertreated chronic medical problems and incipient mental health issues will overwhelm patients and providers. Among the displaced, children may be particularly vulnerable. In New Orleans alone, approximately 110,000 children under age eighteen — 85% of the pre-Katrina pediatric population — have not returned to the city since the hurricanes. These children, and others from outside of New Orleans, have been scattered throughout the Gulf Coast and across the fifty states. Louisiana's school enrollment dropped by 70,000 students, many of whom have resettled in other states, some who have not yet returned to school in Louisiana. The Louisiana Child & Family Health Study focused on the displaced population living in FEMA-subsidized housing in Louisiana, and who may be among the most needy. According to interviews with adults in 665 randomly selected households at trailer communities and hotels throughout the state, this displaced group of children and families suffers from a constellation of serious medical and mental health problems. Parents report high rates of asthma, behavioral problems, and learning disabilities among their children. Despite that, access to continuous medical care, appropriate mental health care, medications, specialized medical equipment, and specialty medical care, is either fragmented at best, or absent altogether. The medical and mental health needs documented in this report may be regarded as the consequence of inadequately treated chronic diseases, psychological and emotional traumas secondary to the chaos and despair of a massive dislocation, and the social deprivations of the chronically-poor and the newly-impoverished. At a deeper level, though, the problems relate to the loss of stability in people's lives: families that are increasingly fragile, children who are disengaged from schools, and the wholesale loss of community, workplace, and health care providers and institutions.
Temporomandibular Joint Arthroscopy

Arthroscopy is a technique for direct visual inspection of internal joint structures, including biopsy and other surgical procedures performed under visual control. In 1918 Takagi first described arthroscopy of the knee joint examinations using cystoscope (Tag, 1939). Onishi in 1970 was the first to report arthroscopy of the human temporomandibular joint (TMJ) and the first results were published by him (Onishi, 1975, 1980). The progress in research and applications of TMJ arthroscopy in joint disease have led to the acceptance of small operative procedures as a safe, minimally invasive means of effectively treating a number of intra-articular and degenerative TMJ problems (McCain, 1992; Holmlund A Holmlund et al., 2001). Arthroscopic surgery has been an effective treatment for TMJ disorders refractory to nonsurgical treatments ( Ohnuki et al., 2003; Gonzalez-Garcia et al., 2008, Leibur et al., 2010). TMJ arthroscopy has been variously reported as successful in up to 80% of cases where outcome of arthroscopic surgery to the TMJ correlates with the stage of internal derangement (K. Murakami et al., 2000; Sanroman, 2004). Studies have been variable in their scientific method and some long-term outcomes studies have been completed where both quality of life and functional outcome have been assessed (Voog et al., 2003a; Undt et al., 2006; Jagur et al., 2011). For enabling direct comparison of the clinical results following arthroscopic surgery and open surgery a retrospective study comparing two centers results using the Jaw Pain and Function Questionnaire ( Clark et al., 1989) has been performed and these treatment results of open surgery were comparable with arthroscopic treatment results (Undt et al., 2006).
Intramuscular Stimulation (IMS)

Chronic pain is common with relatively high incidence and low recovery rates [1]. Chronic pain can cause disability, mild to severe suffering and a serious problem to the health of the public. Chronic pain is localized to the musculoskeletal system in the majority of patients [2]. The most reported forms of chronic musculoskeletal pain are frequently back pain. However non-specific spinal disorders are not possible to identify a pathomorphological source of the problem despite a thorough diagnostic work-up such as simple radiogra‐ phy, computed tomography, magnetic resonance imaging, ultrasound, electromyography and nerve conduction test [1]. There are many potential causatives and aggravating factors associated with non-specific spinal disorders. Though laboratory and radiologic tests provide a myriad of information including the musculoskeletal and nerve system and give important clues for the diagnosis, structural abnormalities and clinical symptoms do not match commonly in clinical practice [3]. Unfortunately some patients do not improve despite administering conservative treatment and then the various interventional thera‐ pies, including medical treatment and/or surgery, and they find themselves in search of a more effective pain relief.
Leucémies secondaires au traitement d'un cancer du sein : la situation à Genève de 1970 à 2000

La prise en charge multidisciplinaire du cancer du sein, ainsi que la mise en place de programmes de depistage ont augmente la survie des femmes atteintes. Toutefois, ce gain s'accompagne d'une augmentation d'effets secondaires a long terme lies au traitement. L'objectif de notre etude etait d'evaluer le risque de developper une leucemie myeloide aigue (LMA) chez les 6360 femmes diagnostiquees d'un cancer du sein a Geneve entre 1970 et 1999, en utilisant les donnees du Registre Genevois des Tumeurs. Nous avons calcule le rapport standardise d'incidence de LMA observee dans la cohorte versus celle attendue dans la population generale, et effectue una analyse multi-variee selon Cox pour identifier les facteurs associes. Par rapport a la population generale, les patientes presentaient un risque 3.5 fois plus eleve de developper une LMA. Cette augmentation du risque etait particulierement marquee chez les femmes de plus de 70 ans et celles traitees par radiotherapie.
A ZVS, quasi-ZCS converter with an improved power rating for 14/42V automotive application

A new converter topology for automotive application is proposed. The topology combines zero voltage switching (ZVS) with quasi zero current switching (quasi-ZCS) to reduce the switching loss. The proposed converter is basically a conventional bridge ZVS converter in which the transformer inductances and an output filter capacitor are used to obtain quasi-ZCS too. Also, the proposed converter power rating is improved by implementation of a series connection of the rectifier output and the input power source. Experimental results show substantial increase of the efficiency in comparison with the standard bridge ZVS converter.
High dose chemotherapy and autologous transplantation in anti-CD20 antibodies era: still a place?

High dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT) is recommended in young (<65 years) patients with diffuse large B-cell lymphoma (DLBCL) without a complete response (CR) after first line chemotherapy or in patients with chemosensitive DLBCL at relapse. According to Italian Society of Haematology guidelines and others, this approach, as first line treatment should be considered in young patients with an intermediate/high or high-risk according to the age-adjusted International Prognostic Index (aa-IPI) only in approved study protocols.1,2 So far, in the pre-rituximab era, no clear benefits were shown in such patients, and conflicting results were generated in randomized studies, with similar survival rates in patients receiving either first-line HDC and ASCT, or standard chemotherapy without rituximab.3-7
Scientometric portrait of nobel laureate Leland H. Hartwell

Leland H. Hartwell was honoured with the Nobel Prize in Physiology or Medicine (2001) at his 62 years age and at 41 years of research publishing career. The first contribution of the author was in 1961 at the age of 22. The number of his contributions in a year peaked in 1997 when it touched 8. He had 108 publications during 1961 – 2001 in domains: Molecular Biology of Cell Cycle Regulation (43), Genetics of Cell Division (48), Genomic Re-arrangement and DNA Repair (9), Molecular Genetics of Yeast Cell Fission (5), and Drug Target Interaction (3) which were analysed for authorship pattern with his 101 collaborators. Most active researchers having number of publications with Leland H. Hartwell were : Weinert, T. A. (10), Garvik, B. M. (8), McLaughlin, C. S. (8), Jenness, D. D. (5). His productivity coefficient was 0.76 which clearly indicates that his productivity increased after 50 percentile age. Highest collaboration coefficient (1) for Leland H. Hartwell was found during 1963-1965, 1968-1969, 1977, 1981-1983, 1985-1990, 1996 and 1998-2001. Journals have been the most preferred channel of communication where, as many as 96 papers out of 108 have been published. The core journals publishing his papers were: Cell (14), Genetics (12), Mol. Cell Biol. (8), J. Bactariol. (7), J. Cell Biol. ( 7), Science (7) J. Mol. Biol.(6), Exp. Cell Res. (5), and Proc. Nat. Acad. Sci.(5). Publication density is 2.63 and Publication concentration is 14.63. Most prolific keywords in titles of publications were: Saccharomyces cerevisiae , Yeast , Cell division cycle , RAD9, DNA Damage , Genes , Cell cycle, Genetic control , Check point (s) , Cell division , Mutant of Yeast.
Living With Drugs

Now in its seventh edition, Living with Drugs continues to be a well-respected and indispensable reference tool. Michael Gossop has updated this new edition to take account of new laws and practices that have come in to place since the previous edition, published in 2007. Written in an accessible style and providing a balanced perspective, the book is ideal for non-specialists in training, such as student nurses and social workers and for anyone with an interest in this complex, ever-present and emotive issue.
Counselling Skills in Social Work Practice

Preface Counselling skills and social work: a relationship Counselling skills for communication Assessing: relevant counselling skills Planning, acting and providing a service: relevant counselling skills Supporting service user choice and advocacy: relevant counselling skills Managing risk and working together: relevant counselling skills Practice within organizations: relevant counselling skills Developing professional competence: relevant counselling skills References Index
TINGKAT KEJADIAN MASTITIS DENGAN WHITESIDE TEST DAN PRODUKSI SUSU SAPI PERAH FRIESIEN HOLSTEIN

Penelitian ini dilakukan di wilayah kerja KUTT Suka Makmur di Kecamatan Grati Kabupaten Pasuruan. Tujuan penelitian ini adalah untuk mengetahui pengaruh mastitis terhadap produksi susu sapi perah. Materi penelitian yang digunakan adalah 35 ekor sapi perah Friesien Holstein (FH) pada bulan laktasi 2 – 3 dan tingkat laktasi 2 – 3. Metode penelitian menggunakan metode survey pada sapi perah yang ada di KUTT Suka Makmur, dengan penentuan sampel sapi perah secara purposive random sampling, yaitu sapi perah dengan tingkat laktasi 2 – 3, dan bulan laktasi 2 – 3. Variable yang diukur adalah produksi susu dan tingkat mastitis. Data dianalisis dengan metode deskriptif. Hasil penelitian menunjukkan bahwa terdapat 14 ekor sapi yang tidak terinfeksi dan 21 ekor yang terinfeksi mastitis. Jumlah puting yang terinfeksi mastitis sebanyak 40 puting atau 47,6% yang berada pada tingkat mastitis satu, dua, tiga dan empat masing-masing adalah sebesar 37,5%, 32,5%, 7,5% dan 22,5%. Ditinjau dari jumlah puting yang terinfeksi mastitis pada satu, dua, tiga dan empat puting masing-masing 42,9%, 33,3%, 14,3% dan 9,5%. Rata – rata produksi susu pada sapi yang tidak terinfeksi mastitis 15,5 lt sedangkan produksi susu rata-rata pada sapi yang terinfeksi mastitis satu sampai empat puting mengalami penurunan, masing-masing sebesar 28,4%, 39,4%, 53,5% dan 51,6%. Berdasarkan hasil penelitian disimpulkan bahwa mastitis dapat menurunkan produksi susu sebesar 4,4 - 8,3 lt/hr/ekor atau 28,4% - 53,5% dan berdampak pada kerugian peternak Rp.6. 160 - Rp.11. 620 / hr/ ekor. Semakin tinggi tingkat mastitis semakin besar penurunan produksi susu, sehingga kerugian peternak semakin besar. Disarankan untuk melakukan perbaikan tatalaksana pemeliharaan, sanitasi dan hygiene agar tingkat kejadian mastitis maupun tingkat mastitis dapat diturunkan. Kata kunci : Mastitis, Produksi susu, Whiteside test.
Metastasis in Squamous Carcinoma

Introductory Secondary deposits of squamous carcinoma, with the possible exception of those in the local lymphatic glands, are of somewhat rare occurrence. Nevertheless, they are sufficiently common to be worthy of record. It is true that several cases of such metastases have been recorded in the literature from time to time, but it is generally agreed that, in comparison with the spheroidal- and columnar-celled tumours, those arising in squamous epithelium relatively rarely give rise to metastases. The problem as to what factors determine the development of secondary deposits in one case of squamous carcinoma, and their absence in another clinically similar case, has not been satisfactorily solved, and it is with a view to correlating the results of pathological investigation with the available clinical data that the present series of clinical cases is recorded. Ewing (1) states that “squamous epithelioma rarely produces bulky metastases,” but he offers no adequate explanation as to the difference in behaviour of different tumours arising in various anatomical sites and developed in the ectodermal and entodermal layers of the embryo. As he points out, the appearance of a secondary tumour at some distance from the primary growth may arise in one of three ways: by multiple origin of primary growths; by continuous extension of a primary growth; by true metastatic growth arising from tumour-cell emboli. Naegeli (2) gives a statistical analysis of 190 cases of primary carcinoma of the skin and aural mucosa seen at Bern. No metastases, however, were observed in the internal organs. Crile (3) found secondary cancer foci in distant organs and tissues in less than 1 per cent of a series of 4,500 cases of cancer of the head and neck, all of squamous epithelial origin.
Promoting Healthy Nutrition through Educational Escape Games

Aim/Purpose: The increased production of processed food, rapid urbanization, and changing lifestyles have led to a shift in dietary patterns so people are now consuming more unhealthy foods. To change unhealthy dietary patterns, there is a need to educate the individuals to keep a balanced diet that is rich in nutritional requirements. One way to educate a heterogeneous population, from preschool to adults, is by learning through games. Background: In recent years, the use of games as a pedagogical method is gaining momen-tum. Game-based learning (GBL) refers to any learning environments or activities that use games to support learning and teaching. GBL enables learners to practice skills that traditional teaching may not offer and promote more efficient learning. GBL includes various types of games; one of them is escape games (EG), which have become a popular trend in the world. Because EG are a relatively new phenomenon, the research on their development and educational value is still in its initial stages. Methodology: The current study is set to develop a methodology for ‘educational EG’ and to examine its role in promoting knowledge, awareness, and motivation toward a healthy nutrition. The study’s theoretical framework is guided by the situated learning theory, as EG are situated in a unique setting that instigates interactions between the players and between them and the learning environment. The research questions are 1. What is the educational potential of escape games? 2. Whether and how can EG promote knowledge, awareness, and motivation toward a healthy nutrition? 3. What are the predicting factors of knowledge, awareness, and motivation toward a healthy nutrition, in the context of educational EG? Contribution: The research’s contributions are in three levels: In the theoretical level, the study contributes a layer of knowledge on situated learning environments, offering a new model for the development and implementation of educational EG. In the methodological level, the study presents valid and reliable research tools for examining the effectiveness of educational EG. In the practical level, the study provides a tangible EG kit on healthy nutrition. Findings: Initial findings indicated on an overall increase in the participants’ positive views about EG as a situated learning environment. The findings also indicated that participation in an EG has a potential to promote knowledge and awareness of nutrition-related issues. The players’ motivation to learn about nutrition increased after participating in the game, mainly due to an increase in their sense of self-efficacy.
El estado nutricional modifica la efectividad de un suplemento dietario de bacterias lácticas sobre la aparición de patologías de vías respiratorias en niños

: One hundred children 6 to 24 month old, normal or undernourished according to weight for height index, received during three months--autumn to winter--a dietary supplement of live Lactobacillus acidophilus and Lactobacillus Casei, 10(7)-10(8)/ml in fermented milk (LB) or an equivalent amount of fluid milk (L) as control. Children's follow-up was performed as outpatients in the Hospital Posadas (Great Buenos Aires). Episodes of respiratory tract infections were recorded and classified according to severity as: Pneumonia (N); Bronchitis (B), Recurrent Obstructive Bronchitis (BOR) and upper respiratory tract infections (CVAS). 58% of children fitted the study protocol, 22 in the LB and 36 in the L group; 21 were undernourished and 37 presented normal weight/height. No deaths were recorded. Total episodes were 103: 34 in LB and 69 in L, that means a frequency of 1.55 and 1.92 episodes/children respectively. In LB a maximum of 3 episodes/children was recorded, meanwhile the number reached 7 in L (p = 0.0373). Severity was higher in L than LB: 0.06 vs. 0 for N; 0.69 vs. 0.45 for B + BOR and 1.17 vs. 1.09 for CVAS. In the control group frequency of severe pathologies was about twice in undernourished than in normal: 0.08 vs. 0.04 for N; 1.08 vs. 0.50 for B + BOR; no difference was found for CVAS. Live lactobacillus supplement suppressed pneumonia and decreased bronchitis in undernourished as well as in normal. In this study undernutrition not only increased the chance of suffering severe acute respiratory tract infections but also impaired the effectiveness of the supplement to decrease severity. The effect is explained on the basis of the immunocompetence depression linked to an inadequate nutritional status.
Influência de comorbidades clínicas na resposta ao tratamento trombolítico em pacientes com acidente vascular cerebral isquêmico

Clinical Comorbidities are Highly Correlated with Functional Outcome in Stroke Thrombolysis Background and purpose: Clinical comorbidities modify prognosis in haemorrhagic and ischaemic stroke. Charlson Comorbidity index is a validated and useful tool for evaluating comorbidity in stroke. In this study we evaluated the effect of clinical comorbidities as measured by Charlson Comorbidity Index in the in ischaemic stroke
Mast Cells and HDL : Studies on Cholesterol Efflux and Reverse Cholesterol Transport

47/2014 Tuomas Lilius New Insights into Enhancing Morphine Analgesia: from Glia to Pharmacokinetics 48/2014 Anmol Kumar Role of 3’UTR in the Regulation of Neurotrophic Factors BDNF and GDNF 49/2014 Yuezhou Zhang Investigating Phosphate Structural Replacements through Computational and Experimental Approaches 1/2015 Bjornar den Hollander Neuropharmacology and Toxicology of Novel Amphetamine-Type Stimulants 2/2015 Jenni Vanhanen Neuronal Histamine and H3 Receptor in Alcohol-Related Behaviors Focus on the Interaction with the Dopaminergic System 3/2015 Maria Voutilainen Molecular Regulation of Embryonic Mammary Gland Development 4/2015 Milica Maksimovic Behavioural and Pharmacological Characterization of a Mouse Model for Psychotic Disorders – Focus on Glutamatergic Transmission 5/2015 Mohammad-Ali Shahbazi Effect of Surface Chemistry on the Immune Responses and Cellular Interactions of Porous Silicon Nanoparticles 6/2015 Jinhyeon Yun Importance of Maternal Behaviour and Circulating Oxytocin for Successful Lactation in Sows Effects of Prepartum Housing Environment 7/2015 Tuomas Herva Animal Welfare and Economics in Beef Production 8/2015 Anna-Maria Kuivalainen Pain and Associated Procedural Anxiety in Adults Undergoing Bone Marrow Aspiration and Biopsy – Therapeutic Effi cacy and Feasibility of Various Analgesics 9/2015 Suvi Itkonen Dietary Phosphorus – Bioavailability and Associations with Vascular Calcifi cation in a MiddleAged Finnish Population 10/2015 Ilkka Liikanen Combining Oncolytic Immunotherapy with Conventional Cancer Treatments 11/2015 Katja Merkkiniemi Predictive Biomarkers in Diffuse Gliomas and Non-Small Cell Lung Cancer 12/2015 Chang-Fang Wang Chemical Surface Modifi cation of Porous Silicon Nanoparticles for Cancer Therapy 13/2015 Nina Nordman Microchip Technology in Mass Spectrometry-Based Bioanalysis: Advances in the Analysis of Peptides, Proteins, and Pharmaceuticals 14/2015 Heli Monttinen The Structural Conservation and Phylogeny of Right-Hand-Shaped Polymerases and Structurally Related Proteins 15/2015 Pirkka-Pekka Laurila Molecular Link between Lipid Metabolism and Energy Homeostasis 16/2015 Matti Kankainen Computational Genomics of Lactobacilli