Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapy behaviours in paediatric rehabilitation: essential attributes for intervention with children with physical disabilities

Abstract Background: Paediatric rehabilitation involves the therapist delivering intervention-specific and non-specific behaviours. Non-specific (or general therapy) characteristics are a key part of family-centred service (FCS); however, little research identifies observable behaviours to examine intervention fidelity to FCS principles and their impact on outcomes. Purpose: To generate a list of observable general therapy attributes essential to FCS interventions for children with physical disabilities. Methods: Attributes of general therapy behaviours were derived based on a Delphi Process with multidisciplinary researchers. A separate method identified attributes through the content analysis of semi-structured interviews with occupational therapists and physiotherapists. A triangulation procedure identified general therapy behaviours for FCS. Results: Eight researchers participated in the Delphi Process. Seventeen therapists participated in semi-structured interviews. The Delphi Process generated 35 behavioural attributes divided into three categories: therapist behaviours (21), client behaviours (9) and client–therapist behaviours (5). Of the 19 attributes generated from the therapist interviews, 17 mapped onto those identified in the Delphi Process. General therapy attributes addressed a range of behaviours including characteristics of the intervention procedure and the therapeutic process. Conclusions: This work provides an improved understanding of how practitioners conceive essential and observable behaviours of FCS that will enable future researchers to identify their presence within an intervention session. Implications for Rehabilitation This article broadens the focus of fidelity measurement of paediatric rehabilitation to include observable behaviours relevant to family-centred service. Attributes of the therapist’s practice behaviour in family-centred service were identified. Attributes of paediatric rehabilitation involving the child’s response to intervention, parent participation and child and therapist interaction were generated.
Argos : emulated hardware support to fingerprint zero-day attacks by means of dynamic data flow analysis

As modern operating systems and software become larger and more complex, they are more likely to contain bugs, which may allow attackers to gain illegitimate access. A fast and reliable mechanism to discern and generate vaccines for such attacks is vital for the successful protection of networks and systems. In this paper we present Argos, a containment environment for worms as well as human orchestrated attacks. Argos is built upon a fast x86 emulator which tracks network data throughout execution to identify their invalid use as jump targets, function addresses, instructions, etc. Furthermore, system call policies disallow the use of network data as arguments to certain calls. When an attack is detected, we perform ‘intelligent’ processor kernel-aware logging of the corresponding emulator state for further off-line processing. In addition, our own forensics shellcode is injected to gather information about the attacked process. By correlating the data logged by the emulator with the data collected from the network, the generation of accurate network intrusion detection signatures is made possible.
SenseCam improves memory for recent events and quality of life in a patient with memory retrieval difficulties

A wearable camera that takes pictures automatically, SenseCam, was used to generate images for rehearsal, promoting consolidation and retrieval of memories for significant events in a patient with memory retrieval deficits. SenseCam images of recent events were systematically reviewed over a 2-week period. Memory for these events was assessed throughout and longer-term recall was tested up to 6 months later. A written diary control condition followed the same procedure. The SenseCam review procedure resulted in significantly more details of an event being recalled, with twice as many details recalled at 6 months follow up compared to the written diary method. Self-report measures suggested autobiographical recollection was triggered by the SenseCam condition but not by reviewing the written diary. Emotional and social wellbeing questionnaires indicated improved confidence and decreased anxiety as a result of memory rehearsal using SenseCam images. We propose that SenseCam images provide a powerful boost to autobiographical recall, with secondary benefits for quality of life.
Impact of DSOI back-gate biasing on circuit conducted emission

This paper presents the impact of FDSOI back gate biasing on circuit conducted emission. The back gate bias can modulate front gate electrical characteristic, and changing the circuit performance and power consumptions dynamically. Meanwhile, the electromagnetic emission of circuit is changing with the back gate variation. A ring oscillator is tested to illustrate the relation between back gate biasing and the conducted emission of the ground pin. The results shows the strong relation of the conducted emission with the front gate electrical parameters.
Solitary fibrous tumour of the renal peripelvis

Solitary fibrous tumours (SFTs) are rare spindle cell neoplasms generally associated with the serosal surface, especially the pleura. This report describes two SFTs arising in the renal peripelvis, occurring in 33‐ and 36‐year‐old females. The lesions lacked the characteristic features of other recognized neoplasms that occur in the kidney. Immunohistochemically, the tumour cells were diffusely and strongly positive for vimentin and CD34, and some tumour cells expressed alpha‐smooth muscle actin. Both tumours were diploid by flow cytometry. Both patients have had benign clinical courses with 7.5‐ and 1‐year follow‐up. The findings suggest that the SFTs may originate from peripelvic mesenchymal cells, a new location for SFT. SFT should be included in the differential diagnosis of spindle cell tumours arising in the renal pelvis and peripelvis.
Pharmacokinetic-pharmacodynamic integration and modelling of florfenicol in calves.

Florfenicol was administered subcutaneously to 10 calves at a dose of 40 mg/kg. Pharmacokinetic-pharmacodynamic (PK-PD) integration and modelling of the data were undertaken using a tissue cage model, which allowed comparison of microbial growth inhibition profiles in three fluids, serum, exudate and transudate. Terminal half-lives were relatively long, so that florfenicol concentrations were well maintained in all three fluids. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration were determined in vitro for six strains each of the calf pneumonia pathogens, Mannhemia haemolytica and Pasteurella multocida. An PK-PD integration for three serum indices provided mean values for P. multocida and M. haemolytica, respectively, of 12.6 and 10.4 for Cmax /MIC, 183 and 152 h for AUC0-24 h /MIC and 78 and 76 h for T>MIC. Average florfenicol concentrations in serum exceeded 4 × MIC and 1.5 × MIC for the periods 0-24 and 48-72 h, respectively. Ex vivo growth inhibition curves for M. haemolytica and P. multocida demonstrated a rapid (with 8 h of exposure) and marked (6 log10 reduction in bacterial count or greater) killing response, suggesting a concentration-dependent killing action. During 24-h incubation periods, inhibition of growth to a bacteriostatic level or greater was maintained in serum samples collected up to 96 h and in transudate and exudate samples harvested up to 120 h. Based on the sigmoidal Emax relationship, PK-PD modelling of the ex vivo time-kill data provided AUC0-24 h /MIC serum values for three levels of growth inhibition, bacteriostatic, bactericidal and 4 log10 decrease in bacterial count; mean values were, respectively, 8.2, 26.6 and 39.0 h for M. haemolytica and 7.6, 18.1 and 25.0 h for P. multocida. Similar values were obtained for transudate and exudate. Based on pharmacokinetic and PK-PD modelled data obtained in this study and scientific literature values for MIC distributions, Monte Carlo simulations over 100 000 trials were undertaken to predict once daily dosages of florfenicol required to provide 50% and 90% target attainment rates for three levels of growth inhibition, namely, bacteriostasis, bactericidal action and 4 log10 reduction in bacterial count.
Addressing geographic confounding through spatial propensity scores: a study of racial disparities in diabetes

Motivated by a study exploring differences in glycemic control between non-Hispanic black and non-Hispanic white veterans with type 2 diabetes, we aim to address a type of confounding that arises in spatially referenced observational studies. Specifically, we develop a spatial doubly robust propensity score estimator to reduce bias associated with geographic confounding, which occurs when measured or unmeasured confounding factors vary by geographic location, leading to imbalanced group comparisons. We augment the doubly robust estimator with spatial random effects, which are assigned conditionally autoregressive priors to improve inferences by borrowing information across neighboring geographic regions. Through a series of simulations, we show that ignoring spatial variation results in increased absolute bias and mean squared error, while the spatial doubly robust estimator performs well under various levels of spatial heterogeneity and moderate sample sizes. In the motivating application, we construct three global estimates of the risk difference between race groups: an unadjusted estimate, a doubly robust estimate that adjusts only for patient-level information, and a hierarchical spatial doubly robust estimate. Results indicate a gradual reduction in the risk difference at each stage, with the inclusion of spatial random effects providing a 20% reduction compared to an estimate that ignores spatial heterogeneity. Smoothed maps indicate poor glycemic control across Alabama and southern Georgia, areas comprising the so-called “stroke belt. ” These results suggest the need for community-specific interventions to target diabetes in geographic areas of greatest need.
Epidemiology and Clinical Profile of HIV/AIDS in Pakistan

This study reviews available data on HIV/AIDS in Pakistan and is the first to analyse a clinical series of HIV-infected patients thus giving a wider perspective of the epidemic in Pakistan. A retrospective analysis of all medical records of patients with HIV/AIDS since 1986 was conducted in March 1998 at a Karachi hospital. There were 67 patients. Twenty-two were overseas (Middle East) contract workers. None were sex workers or drug users. Fifty-four had travelled or lived abroad. High risk sexual behaviour was reported in 35 patients of whom 26 men reported contact with commercial sex workers, mostly in the Middle East (21). The most common AIDS indicator condition was chronic diarrhoea. HIV in Pakistan is currently a disease of those Pakistanis (and their sexual partners) who have travelled abroad, overseas contract workers and those who, prior to 1989, were transfused abroad or received imported blood products.
Outcome of in vitro fertilization in endometriosis-associated infertility: a 5-year database cohort study.

BACKGROUND Endometriosis affects natural fertility through various approaches, and in vitro fertilization (IVF) is a good treatment. But the IVF result of endometriosis patients is still under debate. We investigated the effect of endometriosis on IVF by analyzing the data from a single reproductive center. METHODS A retrospective, database-searched cohort study was performed. Relevant information was collected from the electronic records of women who underwent IVF/intracytoplasmic sperm injection between January 2006 and December 2010 in the Assisted Reproductive Unit of Sir Run Run Shaw Hospital. Patients with endometriosis were enrolled the study group. The rest of the women formed the control group. The main outcome was the clinical pregnancy rate. Secondary outcomes were oocytes retrieved number, fertilization rate, high-quality embryo rate, number of high-quality embryo for embryo transplantation, and implantation embryo/high-quality embryo ratio (IE/HQE ratio). Comparisons were performed by the c(2)-test and independent t-test. RESULTS The endometriosis group (n = 177) had a markedly lower oocytes retrieved number, fertilization rate, implantation rate, and clinical pregnancy rate (7.6 ± 5.1, 63.6%, 27.7%, and 45.2%, respectively) compared with the non-endometriosis group (n = 4267; 11.8 ± 7.3, 68.4%, 36.2%, and 55.2%, respectively). Stratified analysis showed that this difference was found in the subgroup younger than 35-years old, while only fertilization rate and implantation rate were different in the elder subgroup. The ratio of high-quality embryos transferred is lower in endometriosis group (53.7% vs. 71.8%, P < 0.05), but there is no difference in IE/HQE ratio between two groups. There is no significant difference in fertilization rate, implantation rate, and clinical pregnancy rate between mild and severe endometriosis patients. CONCLUSIONS Endometriosis patients suffer a decreasing IVF pregnancy rates mainly caused by reducing oocytes number and fertilization rate, regardless of the severity of the disease. Appropriate intracytoplasmic sperm injection manipulation might improve the outcomes of IVF.
Elevated expression of activated forms of Neu/ErbB‐2 and ErbB‐3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

To assess the importance of Neu activation during mammary tumorigenesis, altered receptors harboring in‐frame deletions within the extracellular domain were expressed in transgenic mice. Females from several independent lines develop multiple mammary tumors that frequently metastasize to the lung. Tumor progression in these strains was associated with elevated levels of tyrosine‐phosphorylated Neu and ErbB‐3. Consistent with these observations, a survey of primary human breast tumors revealed frequent co‐expression of both erbB‐2 and erbB‐3 transcripts. The ability of altered Neu receptors to induce mammary tumorigenesis in transgenic mice prompted us to examine whether similar mutations occurred in ErbB‐2 during human breast cancer progression. Interestingly, an alternatively spliced form of erbB‐2, closely resembling spontaneous activated forms of neu, was detected in human breast tumors. The ErbB‐2 receptor encoded by this novel transcript harbors an in‐frame deletion of 16 amino acids in the extracellular domain and can transform Rat‐1 fibroblasts. Together, these observations argue that co‐expression of ErbB‐2 and ErbB‐3 may play a critical role in the induction of human breast tumors, and raise the possibility that activating mutations in the ErbB‐2 receptor may also contribute to this process.
Sindbis virus nsP1 functions in negative-strand RNA synthesis

A mutation at nucleotide 1101 of Sindbis virus ts11 nsP1 caused temperature-sensitive negative-strand synthesis and suppressed the 24R phenotype, which is caused by a mutation in nsP4. Nonstructural proteins synthesized and accumulated by ts11 at 40 degrees C did not cause the reactivation of negative-strand synthesis upon return to 30 degrees C and did not prevent the formation of new replication complexes at 30 degrees C.
Identifying Threats Associated With Man-In-The-Middle Attacks during Communication between a Mobile Device and the Back End Server in Mobile Banking Applications

Mobile banking, sometimes referred to as M-Banking, Mbanking or SMS Banking, is a term used for performing balance checks, account transactions, payments, credit applications and other banking transactions through a mobile device such as a mobile phone or Personal Digital Assistant (PDA). Mobile banking has until recently most often been performed via SMS or the Mobile Web. Apple's initial success with iPhone and the rapid growth of phones based on Google's Android (operating system) have led to increasing use of special client programs, called apps, downloaded to the mobile device hence increasing the number of banking applications that can be made available on mobile phones . This in turn has increased the popularity of mobile device use in regards to personal banking activities. Due to the characteristics of wireless medium, limited protection of the nodes, nature of connectivity and lack of centralized managing point, wireless networks tend to be highly vulnerable and more often than not they become subjects of attack. This paper proposes to identify potential threats associated with communication between a mobile device and the back end server in mobile banking applications. The paper should be able to identify the techniques associated with Man in the middle attacks during communication between a mobile device and a back end server and propose controls that will ensure that data theft does not occur during such sessions.
Manipulability and singularity analysis of multiple robot systems: a geometric approach

We present a differential geometric analysis of manipulability for holonomic multiple robot systems containing active and passive joints. Our analysis treats both redundant and nonredundant systems, including the case of redundant actuation, in a uniform manner. Dynamic characteristics of the robot system and manipulated object can also be naturally included by an appropriate choice of Riemannian metric. Our geometric framework also suggests a classification of kinematic singularities into three basic types: (i) those corresponding to singular points of the joint configuration space (configuration space singularities), (ii) those induced by the choice of actuated joints (actuator singularities), and (iii) those configurations in which the end-effector loses one or more degrees of freedom of available motion (end-effector singularities). The proposed geometric classification provides a high-level taxonomy for kinematic singularities that is independent of the choice of local coordinates used to describe the robot kinematics.
Warfarin-Induced Tissue Necrosis (WITN): Case Report and Literature Review, A Proposed Name Change

Volume 1 | Issue 1 Warfarin-Induced Tissue Necrosis (WITN): Case Report and Literature Review, A Proposed Name Change Simman R*1, Gould N2 and Jackson SE3 1Plastic and Reconstructive Surgery, Pharmacology and Toxicology, Wright State University Boonshoft School of Medicine, Dayton Ohio 2Family Medicine Program, Grand View Hospital, Kettering Health Network. Dayton, Ohio 3Clinical Assistant Professor of Internal Medicine, Wright State University Boonshoft School of Medicine, Dayton, Ohio *Corresponding author: Simman R, Department of Surgery, Wright State University Boonshoft School of Medicine, E-mail: plasticsimman@yahoo.com Case Report Open Access Volume 1 | Issue 1 Journal of Surgery and Operative Care
Les ressources minérales et végétales de la Cerdagne orientale

Cet article offre un apercu de l'exploitation des ressources minerales et vegetales de la Cerdagne dans les temps anciens. L'analyse archeologique se concentre sur l'etude de ressources telles que le bois, les mines, les fours de chaux, les charbonnieres et les points de transformation des minerais.
Effect of vitamin D3 supplementation on the pharmacokinetics of digoxin – a pilot study

Emerging evidence from preclinical, clinical and epidemiological studies suggests that vitamin D3 plays vital roles in several diseases in addition to bone disorders. According to new medical evidence, it is being recommended that vitamin D3 intake to be increased for maximal benefits in human health. However, it is necessary to consider potential side effects of increased intake of vitamin D3. Vitamin D3 exerts its actions through the vitamin D receptor, which is known to be an important regulator of P‐glycoprotein (P‐gp). As P‐gp plays a significant role in limiting drug bioavailability, we undertook a study to compare single‐dose digoxin (a P‐gp substrate) pharmacokinetics in eight healthy male subjects before and after vitamin D3 supplementation (1000 IU per day). The geometric mean ratios for AUC0–3h, AUC0–48h and Cmax were 1.06 (90% CI 0.92, 1.21) and 1.02 (90% CI 0.97, 1.08) and 1.03 (95% CI 0.86, 1.24), respectively. The median for digoxin Tmax was 0.75 h before and after vitamin D3 ingestion. The mean plasma 25‐hydroxyvitamin D3 (25(OH)D3) levels remained constant after the intake of vitamin D3 (15.4 ± 3.7 and 14.4 ± 3.6 ng/mL, respectively), while there was a modest but statistically significant increase in plasma calcium levels, from 9.32–9.68 mg/dL (P = 0.0277). These results suggest that vitamin D3 supplementation (1000 IU per day) in human volunteers does not produce a P‐gp‐mediated drug interaction with orally administered digoxin.
Superconducting Inductors for Ultra-High Frequency Power Conversion

We present results of construction and testing of an ultra-high frequency thin film high temperature spiral the superconducting inductor. The result shows that superconducting inductor is almost lossless compared to an identical spiral inductor made of copper at ultra-high frequencies (> 100 MHz). Furthermore, the superconducting inductor is capable of carrying high currents. Therefore, we show that for ultra-high frequency power conversion, a superconducting inductor is a viable option in applications where liquid nitrogen cooling can be implemented. We further demonstrate, by using finite element model (FEM), that the lower quality factor and efficiency of copper inductor is due to current crowding near the short edges of the copper conductors. In addition, using FEM we demonstrate the need for shielding at such high frequencies.
Layers of Languages for Self-Modeling Systems

Self-Modeling Systems are computing systems that have complete models of their own behavior, down to some level of detail, and that interpret those models to produce that behavior (in some applications, the interpreter itself is also modeled). Then when the system changes the models, it changes its own behavior. We have shown how our Wrappings integration infrastructure facilitates the construction, operation, and management of these systems, and the appropriate limitation of their variability. In this paper, we argue that the internal reflective processes are well-suited to representation by different languages, and that as more languages are used, each one can be simpler in definition and in its relationships to semiotically neighboring ones. Furthermore, the seeming proliferation of internal languages can be organized to have very little performance impact, since constant mappings can be made directly through partial evaluation. In computing terms, we are showing the useful separation into granularity and abstraction layers of the different kinds of activity descriptions needed in the models. We illustrate the methods and approach on CARS (Computational Architecture for Reflective Systems), a testbed for studying cooperating distributed embedded systems.