Miracle-dz/UniFAR-FTUs huggingface dataset:
Esferoides como modelo predictivo de respuesta tumoral a la terapia génica : Estudio de los efectos de la transferencia génica no viral del sistema gen suicida y del gen de interferón-beta en esferoides derivados de melanoma espontáneo canino

Los esferoides constituyen un modelo experimental que se asemeja mas al comportamiento de los tumores in vivo que sus respectivas monocapas. Por lo tanto su estudio e implementacion en el desarrollo de nuevas estrategias terapeuticas para combatir el cancer es de suma importancia. En el presente estudio demostramos que la respuesta a la transferencia no viral del sistema gen suicida HSVtk/GCV de esferoides formados a partir de lineas celulares derivadas de tumores de melanoma espontaneo canino correlaciona mejor con la respuesta de los pacientes que sus respectivas monocapas. Tambien observamos que la resistencia multicelular (MCR) al sistema HSVtk/GCV presente en los esferoides probablemente se deba a una rapida repoblacion de las celulas resistentes al tratamiento en esta configuracion espacial. La gran cantidad de lineas cuyos esferoides resultaron ser sensibles al sistema HSVtk/GCV y/o a la transferencia no viral del gen cIFN-β (80% sobre un total de 15 lineas) y el mantenimiento de la sensibilidad al ser co-transferidos demuestran la gran potencialidad terapeutica de la co-administracion de ambos genes. Como alternativa a la electroporacion, encontramos una forma menos agresiva de aumentar la penetracion intracelular de bleomicina: la lipofeccion. Encontramos que el sistema lipoplexes/bleomicina es altamente efectivo pues la presencia de los lipoplexes sensibiliza a las celulas al efecto citotoxico de la bleomicina, posiblemente estimulando el ingreso de la droga a las celulas mediante un transporte activo.
Secured Credit Card Transaction Using MCOP

With the improvement of changed correspondence systems, online payment exchanges and in addition web based business is spreading step by step. Additionally, the money related cheats related with these exchanges are likewise expanding which in this manner brings about significant budgetary misfortunes consistently comprehensively. Credit card extortion is drilled most every now and again among the changed money related cheats because of its acknowledgment and across the board use as it offers more accommodation to its clients. Monetary foundations, for example, banks require more advanced methods for recognizing misrepresentation. Budgetary fakes are frequently difficult to distinguish and break down as the deceitful conduct is changing, scattered in unmistakable client profiles, and spread crosswise over gigantic imbalanced genuine datasets (e.g. client spending profiles, web logs, exchange logs). Moreover, clients once in a while audit their web based keeping money history and thus are not ready to uncover the false exchanges at the ideal time. Likewise, because of the wide use of credit cards as a method of payment for acquiring merchandise and enterprises, there comes a need to decide if the exchanges made using a credit card is a substantial exchange done via card holder or it is a deceitful exchange done by the fraudster. To stay away from or control the online extortion this review presents another method Multi Combination of Password Technique (MCOP).
THE EFFECT OF MENTAL STRESS ON EMPLOYEES' JOB PERFORMANCE (CASE STUDY OF SOCIAL SECURITY ORGANIZATION OF KHUZESTAN)

This research aims to examine the effect of mental stress on employees' job performance in social security organization of Khuzestan and define the factors of mental stress on job performance and also to examine the status of job performance in this organization. The study sample consisted of male and female employees of the social security organization of Khuzestan which 200 of them were selected as sample members. For data collection, mental stress- job pressure measurement questionnaire and evaluation of the efficiency of individual's questionnaire were used. By using the Cronbach's alpha and assistance of spss software, reliability coefficient was calculated which based on conducted calculations, the reliability coefficient of questionnaire related to job stress measurement, α = 0.856 and the reliability coefficient of performance efficiency measurement questionnaire α = 0.95. Pearson's correlation coefficient was used to analyze the hypothesis and the significance level α = 0.05 was considered to test the hypothesis. The findings showed that mental stress on the individual level influences performance efficiency and there is a significant positive relation between individual mental stress and efficiency. No significant relation has been observed between organizational and extra- organizational mental stress and performance efficiency in this organization.
peptide Mimetics of Terminal sugars of complex Glycans

In this project we asked whether short peptides would mimic complex carbohydrate structures and express biological activity. Amino acid sequences were identified as potential glycan mimetics by molecular modeling of docking to binding sites of lectins. The sequence HPSLK was synthesized as a quadravalent structure from a tri-lysine scaffold. Solid-phase assays showed that this peptide bound strongly to lectins from Triticus vulgaris (wheat germ agglutinin, WGA) and Dolichos biflorus (DB), which bind monosaccharides, and to lectins from Sambucus nigra (SNA1) and Maackia amurensis (MAA), which are specific for oligosaccha- rides with terminal 5-acetylneuraminic acid-galactose sequences. Further modeling led to synthesis of a longer peptide, NPSHPSLG, along with a variant, NPSHPLSG, as quadravalent structures. The longer peptides bound weakly, if at all, to WGA and DB but bound strongly to SNA1 and MAA. Mucin inhibited binding of HPSLK to WGA and DB, while fetuin inhibited binding of NPSHPSLG and NPSHPLSG to SNA1 and MAA. These results suggest that the peptides interact with the lectins at glycan-binding sites. When tested for biological activity, the peptides stimulated internalization of opsonized microspheres, which was blocked by wortmannin, an inhibitor of phagocytosis. Whereas HPSLK stimulated phosphorylation of the signaling proteins STAT2 and STAT6, NPSHPSLG and NPSHPLSG stimulated phosphorylation of STAT6, a marker for the alternative activation of phagocytosis, more strongly than STAT2. Our results suggest that these synthetic peptides may be useful as biological response modifiers.
Security Threats/Attacks Present in Cloud Environment

Summary Cloud computing is a popular subject across the IT industry, but risks associated with this new technology and delivery model is not yet well understood. The biggest challenge in cloud computing is the security and privacy problems caused by its multi-tenancy nature and the outsourcing of infrastructure, sensitive data and critical applications. Enterprises are rapidly adopting cloud services for their businesses, measures need to be developed so that organizations can be assured of security in their businesses and can choose a suitable vendor for their computing needs. The boom in cloud computing has brought lots of security challenges for the consumers and service providers. How the end users of cloud computing know that their information is not having any a v ailability and security issues? In this paper we identify the most vulnerable security threats/attacks in cloud computing, which will enable both end users and vendors to know about the key security threats associated with cloud computing and propose relevant solution directives to strengthen security in the Cloud environment. We also propose secure cloud architecture for organizations to strengthen the security.
Enhancing Availability of Services Using Software-Defined Networking

The immense growth of client requirements imposed on data centre and cloud providers results in a conflict with traditional networking concepts lacking the required agility. In order to promote flexibility, which data centre providers promise to their clients, this discrepancy needs to be resolved, for instance by employing the novel concept of Software-Defined Networking (SDN). This paper utilises this concept in order to minimise service downtime while performing live virtual machine migration. The work is aimed at small/medium-sized data centres and hence the findings are based on real communication patterns found in such environments. Results show that packet loss is slightly diminished while available throughput is increased thanks to the proactive approach taken during network topology changes when compared to the traditional approach based on L2 forwarding.
Cluster Systems - An Open-Access Design Solution

An open-access cluster computing facility, believed to be the first of its type, has been established at the University of Sunderland. This paper describes its computing and networking architecture in terms of hardware and Operating Systems platforms, taking into account the need for low energy consumption and low heat dissipation. The system described operates in an open environment, without the need for air conditioning. A dual boot configuration allows performance comparisons to be made between different Operating System platforms on identical hardware. As a result of its general purpose design, the cluster is able to support a wide range of applications across a number of disciplines, most notably engineering and media.
Automatically Generating Questions to Support the Acquisition of Particle Verbs: Evaluating via Crowdsourcing.

We integrate insights from research in Second Language Acquisition (SLA) and Computational Linguistics (CL) to generate text-based questions. We discuss the generation of whquestions as functionally-driven input enhancement facilitating the acquisition of particle verbs and report the results of two crowdsourcing studies. The first study shows that automatically generated questions are comparable to human-written ones. The second study investigates different types of questions, their perceived quality, and the responses they elicit.
Canvis en l'epidemiologia del pneumococ en el nostre medi

RESUM Introduccio. Tot i la utilitzacio de la vacuna pneumococcica conjugada heptavalent (PCV7), l' Streptococcus pneumo- niae continua sent un important problema de salut publica. Objectiu. Analitzar l'evolucio de la malaltia invasiva pneu- mococcica en l'era de la vacuna conjugada heptavalent amb una referencia especial a la nostra area geografica. Metode. Revisio no sistematica. Resultats. La introduccio de la PCV7 s'ha associat amb el fe- nomen del reemplacament de serotips a la nasofaringe. El reemplacament implica que els serotips no vacunals adqui- reixen un avantatge ecologic a l'hora de colonitzar la naso- faringe. Com a consequencia, augmenta la seva prevalenca com a portadors i en una segona etapa com a productors de malaltia. La pneumonia, amb empiema o sense, ha estat la principal manifestacio clinica relacionada amb la malaltia produida per serotips no vacunals. El reemplacament de se- rotips es un fenomen multifactorial i altres factors diferents a la vacunacio tambe es relacionen amb aquest fet. Conclusions. Una nova generacio de vacunes conjugades que incloguin un rang mes ampli de serotips milloraria la cobertura vacunal. D'altra banda, el desenvolupament de vacunes proteiques que frenin la malaltia invasiva, pero que preservin la colonitzacio, podria tenir un impacte posi- tiu de la vacunacio antipneumococcica a llarg termini
A study about the learning of students who worked with computational modeling and simulation in the study of simple electric circuits

The purpose of this research was to investigate the learning of students who worked with computational modeling and simulation using the software Modellus in the study of simple electric circuits. The theoretical framework was based on Ausubel's theory of meaningful learning and Halloun's schematic modeling approach. The quantitative results show that there were statistically significant differences in the performance of students who worked with the computational activities (experimental group), when compared to the one in which students were just exposed to a traditional method of teaching (control group). The qualitative results suggest that many students from the experimental group seemed to have achieved meaningful learning, and the students' interaction among themselves and with the teacher as well during the computational activities has strongly contributed for that.
Membrane dynamics and the biogenesis of lysosomes (Review)

Lysosomes are dynamic organelles receiving membrane traffic input from the biosynthetic, endocytic and autophagic pathways. They may be regarded as storage organelles for acid hydrolases and are capable of fusing with late endosomes to form hybrid organelles where digestion of endocytosed macromolecules occurs. Reformation of lysosomes from the hybrid organelles involves content condensation and probably removal of some membrane proteins by vesicular traffic. Lysosomes can also fuse with the plasma membrane in response to cell surface damage and a rise in cytosolic Ca 2+ concentration. This process is important in plasma membrane repair. The molecular basis of membrane traffic pathways involving lysosomes is increasingly understood, in large part because of the identification of many proteins required for protein traffic to vacuoles in the yeast Saccharomyces cerevisiae. Mammalian orthologues of these proteins have been identified and studied in the processes of vesicular delivery of newly synthesized lysosomal proteins from the trans-Golgi network, fusion of lysosomes with late endosomes and sorting of membrane proteins into lumenal vesicles. Several multi-protein oligomeric complexes required for these processes have been identified. The present review focuses on current understanding of the molecular mechanisms of fusion of lysosomes with both endosomes and the plasma membrane and on the sorting events required for delivery of newly synthesized membrane proteins, endocytosed membrane proteins and other endocytosed macromolecules to lysosomes.
Diagnosing Housing Bubbles across Rich Countries

This paper addresses an empirical puzzle in the housing bubble literature: models of market fundamentals perform poorly in explaining investor exuberance in housing even though, individually, many fundamentals have strong ability to predict explosive growth in real house prices. We explore two plausible sources for the poor performance: missing fundamentals and missing bubble dynamics. To shed light on the relative importance of these sources, we conduct a detailed two-step investigation of the housing markets in ten rich countries using models, methodologies and datasets that are similar to those employed in the existing literature. Our findings consistently show that the predictive ability of models of market fundamentals can be dramatically enhanced once missing dynamics of housing bubbles are properly accounted for. GSADF denotes Generalised Sup Augmented Dickey–Fuller test and SADF denotes Sup Augmented Dickey–Fuller test.
Metodologías para el análisis de coberturas periodísticas en situaciones de crisis: las estrategias de comunicación y el caso Prestige

En la modernidad liquida, entendida en los terminos propuestos por Zygmunt Bauman, lo efimero, lo virtual y el cambio se convierten en la norma, mientras lo estatico y lo permanente ven severamente amenazada su estable posicion de privilegio predominante a lo largo de los ultimos siglos. Para el sociologo polaco “una modernidad solida consideraba los accidentes, las contingencias, las indeterminaciones, los imprevistos, las sorpresas, los cambios de curso en los acontecimientos como irritaciones temporales” (Bauman, 2004). Por el contrario, una moderna sociedad liquida seria aquella que asume el cambio como una condicion permanente de la vida, obligando a la ciudadania a asumir tres principios basicos en su quehacer diario: incertidumbre, riesgo continuo y confianza variable.
Impact of Economic Condition on Obesity

Prevalence of obesity has increased with alarming rate in the last two or three decades worldwide. The prevalence statistics shows that obesity pandemic is all-pervading even in the developing nations like India. In the present study an attempt has been made to report the prevalence of obesity on the basis of body mass index among school girls of Punjab, total 6000 students were selected with stratified random sampling technique, ranging in age from 10-17 years. The data was obtained from various government and private schools of Punjab based on economic status (1009 from high economic status, 2228 from middle economic status & 2763 from low economic status group). Height of each individual is measured with anthropometric rode and the body mass index (BMI) was calculated by the bio electrical impedance machine with scale HBF-361. Further analysis of variance (Anova) and Scheffe’s post hoc test was employed for testing the hypothesis; the level of significance was set at 0.05 levels. The results show that overweight & obesity was more prevalent among those girls who are associated from high economic status families & vice versa.
Application of independent component analysis in vibration

This paper investigates the application of Independent Component Analysis (ICA) in vibration of structures to infer excitation forces from vibration response signals only. First, fundamental notions of ICA, statistical independence (SI) of variables and an ICA algorithm for real number, fastICA, were reviewed. The performance of ICA was assessed using harmonic force excitation as source signals and mixture signals are displacement responses from finite element simulation of vibration of a cantilever beam. It was found that fastICA could extract source signals that share most dynamic characteristics of the excitation source signals. Further studies are proposed to tailor ICA better to vibration signals.
Rural Tourism in India– A Model of Rural Culture & Heritage

The objective of this paper is to present an update on rural tourism growth & development in India. Rural tourism is growing in terms of number of visitors and the government of India focuses on it as an engine of growth. We believe that any rural tourism development plan needs to focus on sustainable development and take into account the priorities and needs of local people. This paper emphasizes the need for sustainable forms of tourism by outlining the possible socio-economic, cultural and environmental impacts of current forms of Rural Tourism. The paper first explores the meaning of terms such as Rural, Rurality and Rural Tourism. It focuses on the genesis and growth of rural tourism, rural tourism in India, impacts of rural tourism and the need for sustainable rural tourism.
Design Considerations For Rotary-Field Ferrite Phase Shifters

Key factors influencing the design of a rotary-field ferrite phase shifter are the required r-f performance, the desired control characteristic and the switching time. These factors are examined as a function of the saturation magnetization of the ferrite and the number of turns on the drive yoke. A performance table is presented giving the characteristics of these phase shifters in the 2-20 GHz range.
A sequential quadratic penalty method for nonlinear semidefinite programming

In this article, a nonlinear semidefinite program is reformulated into a mathematical program with a matrix equality constraint and a sequential quadratic penalty method is proposed to solve the latter problem. We discuss the differentiability and convexity of the penalty function. Necessary and sufficient conditions for the convergence of optimal values of penalty problems to that of the original semidefinite program are obtained. The convergence of optimal solutions of penalty problems to that of the original semidefinite program is also investigated. We show that any limit point of a sequence of stationary points of penalty problems satisfies the KKT optimality condition of the semidefinite program. Smoothed penalty problems that have the same order of smothness as the original semidefinite program are adopted. Corresponding results such as the convexity of the smoothed penalty function, the convergence of optimal values, optimal solutions and the stationary points of the smoothed penalty problems are obtained.
Study on the Motives of Inefficient Investment of Listed Companies

Based on the fundamental theory of value effects of investment, this paper investigates the motives of inefficient investment of listed company in China. Regression results using 3155 Shanghai and Shenzhen listed company observations in 2003-2005 show that investment is sensitive to cash flows when we control the growth opportunity, suggesting that some degree of inefficient investment of listed companies exists. Moreover these relationships are much stronger for state-owned listed companies. The motive test show that investment is positively correlated to future operational performance significantly for both state-owned and nonstate-owned listed companies, which means the reason why listed companies engaged in inefficient investments lies in agent conflicts between shareholders and managers, therefore the main form of inefficient investment of listed companies is overinvestment. Key words: Financial constraints; Agent conflicts; inefficient investment; Investment-cash flow sensitivity
Social divisions defining voting behavior: impact of cleavages on party choice

4 INTRODUCTION. 5 1. CLEAVAGES IN VOTING BEHAVIOR . 9 1.1. DEFINITION OF CLEAVAGES . 9 1.2. THEORY OF FROZEN PARTY SYSTEMS . 10 1.3. ORIGIN OF CLEAVAGES. SOCIAL STRUCTURE OR PARTY SYSTEM? 13 1.3.1. Top-down approach . 15 1.3.2. Bottom-up approach . 16 1.4. DECLINE OF SOCIAL CLEAVAGES . 17 2. AN OUTLINE OF CLEAVAGES . 22 2.1. CLEAVAGES AND SOCIAL DIVISIONS . 22 2.1. COMPOSITION OF CLEAVAGES . 24 2.1.1. Economic cleavage . 25 2.1.2. Religious Cleavage . 28 2.1.3. Residential cleavage . 30 2.1.4. National cleavage . 31 2.1. 5. Value cleavage . 33 2.2. DIFFERENCES IN CLEAVAGE VOTING BETWEEN WORLD’S REGIONS . 35 3. MEASURING CLEAVAGE VOTING . 38 3.1. CONSIDERATIONS OF MEASUREMENT . 38 3.1.1. Traditional and total cleavage voting . 38 3.1.2. Absolute and relative cleavage voting . 39 3.1.3. Bivariate and multivariate models . 40 3.1.4. Level of measurement . 41 3.2. METHODS OF MEASUREMENT . 42 3.3. MODEL DESIGN . 45 3.4. DATA . 46 3.5. OPERATIONALIZATION OF VARIABLES. 47 4. RESULTS . 52 4.1. COMPARISON OF CLEAVAGE COMPONENTS . 52 4.1. RELEVANCE OF CLEAVAGES . 56 4.2. REGIONAL DIFFERENCES . 57 CONCLUSIONS . 62 REFERENCES . 65 APPENDICES . 70 KOKKUVÕTE . 71
The Effect of Ownership on the Prudential Behavior of Banks - The Case of China

Although the relationship between bank ownership and performance is the current focus of much research, this paper investigates the relationship between ownership and the prudential behavior of banks. Using Chinese data, I show that lending by state-owned banks has been less prudent than lending by joint-equity banks, but has improved over time. This is consistent with the hypothesis that accountability to shareholders and depositors gives joint-equity banks a better incentive than state-owned banks to engage in prudent lending, and with the hypothesis that the reform of the banking system has improved the incentive for state-owned banks to behave more prudently in their lending.