Miracle-dz/UniFAR-FTUs huggingface dataset:
Hydrolysis of sulfonylurea herbicides in soils and aqueous solutions: a review.

Sulfonylureas are a unique group of herbicides used for controlling a range of weeds and some grasses in a variety of crops and vegetables. They have been extremely popular worldwide because of their low mammalian toxicity, low use rate, and unprecedented herbicidal activity. Knowledge about the fate and behavior of sulfonylurea herbicides in the soil-water environment appears to be of utmost importance for agronomic systems and environmental protection. Because these herbicides are applied at a very low rate, and their mobility is greatly affected by the chemicals' anionic nature in alkaline soils, a thorough understanding of their degradation/hydrolysis processes and mechanisms under aqueous and soil systems is important. This review brings together published information on the hydrolysis of several sulfonylureas in aqueous and soil solutions that includes the effects of pH, temperature, functional relationship between pH vs hydrolysis rate constants, and hydrolysis behavior of sulfonylureas in the presence of minerals. In addition, the transformations of sulfonylureas in soil, under laboratory and field experiments, have been discussed in connection with the compounds' varied structural features, i.e., sulfonylueas that are with or without the pyridinic, pyrimidine, and triazinic ring.
Evaluation of Anti Hyperglycemic Studies on Hypericum hookerianum in Streptozotocin ( STZ ) and Nicotinamide Induced Diabetic Rats Murugesan

The aim of this study was investigate antihyperglycemic effect of ethyl acetate extracts of leaves and stem of Hypericum hookerianum (HH) as in streptozotocin and nicotinamide induced diabetic rats. Male Wistar rats were administrated with leaf (HHL) and stem(HHS) extracts (200 mg/kg)of Hypericum hookerianum orally for 28days and blood glucose was measured once in week about 4weeks.The HHL extract showed more reduction in blood glucose leavel by 49 % on the 4the week of treatment when compared to controlled STZ group. At the end of the study significant reduction in lipid profile such as Triglycerides, HDL, Total Cholesterol, along with urea, uric acid and creatinine were found to be reduced in treated group. The experimental data revealed that the HHL extract posses significant antihyperglycemic effects than HHS extracts.
A VERSATILIDADE DA MADEIRA LAMINADA COLADA

O proposito deste trabalho foi apresentar os tipos de ligacoes e juntas de madeira com as suas principais caracteristicas e utilizacoes no contexto da construcao civil, apontando, de forma concisa, as vantagens e desvantagens da aplicacao de cada uma delas. Em seguida, caracterizamos a Madeira Laminada Colada (MLC) e descrevemos o seu processo de fabricacao, principalmente na Europa, e sua introducao no mercado brasileiro. No estudo de caso, apresentamos uma obra singular onde podemos contemplar todos os recursos e primazias da utilizacao da Madeira Laminada Colada. Para atender as demandas da arquitetura contemporânea, cada vez mais arrojadas, as pesquisas e inovacoes tecnologicas tem possibilitado mais versatilidade no emprego de materiais nas edificacoes. O entalhamento usual nas juntas de madeira evoluiu, as juntas mecânicas e coladas passaram a atender as novas exigencias estruturais permitindo maior flexibilidade no sistema construtivo. Surge, entao, a Madeira Laminada Colada (MLC), colocando a utilizacao da madeira com eficiencia construtiva definitivamente no mercado da construcao civil.
Public Expectations for Return of Results from Large-Cohort Genetic Research

The National Institutes of Health and other federal health agencies are considering establishing a national biobank to study the roles of genes and environment in human health. A preliminary public engagement study was conducted to assess public attitudes and concerns about the proposed biobank, including the expectations for return of individual research results. A total of 141 adults of different ages, incomes, genders, ethnicities, and races participated in 16 focus groups in six locations across the country. Focus group participants voiced a strong desire to be able to access individual research results. Recognizing the wide range of possible research results from a large cohort study, they repeatedly and spontaneously suggested that cohort study participants be given ongoing choices as to which results they received.
[Program for the prevention of chronic kidney disease based on integrated service networks in Colombia].

OBJECTIVE Chronic Kidney Disease (CKD) prevention programs allow to control morbidity and/or delay renal replacement therapy. The design of a CKD prevention program is described, including highlights on how the primary and secondary levels of care interact with each other through the characterization of the population admitted for secondary prevention. METHODS The description of the program was based on a literature review. Descriptive statistics were used to characterize the patients participating in the program. RESULTS The design and implementation of the prevention program was based on the integration of service networks and care levels. The main activities for the program were detailed according to the care level in which they performed. 3 487 patients in total were admitted for control at the second care level due to an estimated glomerular filtration rate of <60 mil/min; 87.81% of the patients were admitted with CKD stage 3 and a median glomerular filtration rate of 46.21mil/min. The main causes of CKD were hypertension and diabetes. On admission, 2 129 patients (61.05 %) had systolic blood pressure <140 mmHg and 3 091 (88.64 %) had diastolic blood pressure <90 mmHg; 357 (57.58 %), out of 620, diabetic patients with glycosylated hemoglobin presented values <7.5 %. CONCLUSION A prevention program was designed and implemented to allow the integration of care levels oriented to a multidisciplinary intervention, which ultimately managed to recognize patients and to give continuity to care provision for a better control of CKD.
Public policy and obstacles to the virtual agora: Insights from the deliberative e-rulemaking project

Cyber-optimists anticipate that electronic media will serve as an extensive public space, a virtual agora, that will re-engage the public with politics and the policies that affect everyday life. For three years we were involved in a U.S. National Science Foundation funded project designed to enhance the participation of citizens in government agency rulemaking processes using online public deliberation and Natural Language Processing technologies. Despite a promising approach in an important arena for direct and regular public engagement, the project was met with serious obstacles in trying to secure a partnership with a government agency or interest groups. This led us to consider the policy process literature for insights regarding the obstacles we faced. That literature, a mainstay in the public policy and public administration curriculum in the U.S. and an attempt to capture how policy makers actually make decisions, heavily focuses on institutional actors and their adversarial relationships. Yet, it provides for hardly any role for the public to participate in what ideally should be a democratic process. Important components of the literature imply that institutional actors should discourage direct public engagement. The analysis seeks to clarify leverage points and contexts that could be used to promote online public engagement as a regular component of government processes.
Selective left‐lobe atrophy by nodularin treatment accompanied by reduced protein phosphatase 1/2a and increased peroxisome proliferation in rat liver

The effect of nodularin on selective atrophy of left lobes in the liver was investigated in F344 rats. Nodularin was injected for 10 weeks from the third week of initiation with saline or N‐nitrosodiethylamine (DEN), grouped as S/N and D/N, respectively. Nodularin significantly decreased weights of left (LL) and caudate (CL) lobes but increased right (RL) and middle (ML) lobes in S/N rats. Activity of protein phosphatases [types 1 (PP1) and 2A (PP2A)] was more severely reduced in S/N than D/N rats; moreover, in LL compared with RL of S/N rats, activity was significantly inhibited by nodularin treatment from week 4, which corresponded to 2 weeks after nodularin injection. However, nodularin significantly induced peroxisomal palmitoyl‐CoA oxidase and cytochrome P‐450 4A1 expression in S/N compared with D/N rats. An effect of nodularin on apoptosis was evident since expression of Bcl‐XS was clearly induced in LL of S/N rats as opposed to various inductions of Bcl‐XL. However, Bcl‐XL in RL was persistently induced, with undetectable Bcl‐XS expression. These results demonstrate biochemical evidence of selective atrophy of LL by inhibition of PP1 and PP2A activity, increase of peroxisomal enzymes and induction of Bcl‐XS expression, in contrast to proliferation of RL in rats treated with nodularin alone. However, nodularin endowed DEN‐altered hepatocytes with regenerating power and concomitant restoration of phosphatase activity as well as persistent expression of Bcl‐XL in D/N rats. Int. J. Cancer 91:32–40, 2001. © 2001 Wiley‐Liss, Inc.
Telemedicine Adoption and Sustainability in Extreme Resource Poor Countries

The value and importance of telemedicine and adoption in developed countries is growing, especially due to an increase in m-health applications. In resource poor communities and developing countries often telemedicine is adopted because it is the only available option. The scarcity of medical professionals and equipment, distances between care centers, and the high cost for obtaining medical care makes telmedicine an increasingly attractive solution. This paper reports on the need for a new model for telemedicine adoption in extreme resource poor countries. The authors made several service and research trips to Haiti between 2014 and 2015. We observed that the adoption theories used in developed countries like the US do not adequately describe the adoption process in Haiti. Based on our findings and experience in Haiti we propose a new adoption model for extreme resource poor countries.
Detection of imprinting effects for qualitative traits on X chromosome based on nuclear families

Methods for detecting imprinting effects have been developed primarily for autosomal markers. However, no method is available in the literature to test for imprinting effects on X chromosome. Therefore, it is necessary to suggest methods for detecting such imprinting effects. In this article, the parental-asymmetry test on X chromosome (XPAT) is first developed to test for imprinting for qualitative traits in the presence of association, based on family trios each with both parents and their affected daughter. Then, we propose 1-XPAT to deal with parent–daughter pairs, each with one parent and his/her affected daughter. By simultaneously considering family trios and parent–daughter pairs, C-XPAT (the combined test statistic of XPAT and 1-XPAT) is constructed to test for imprinting. Further, we extend the proposed methods to accommodate complete (with both parents) and incomplete (with one parent) nuclear families having multiple daughters of which at least one is affected. Simulation results demonstrate that the proposed methods control the size well, irrespective of the inbreeding coefficient in females being zero or non-zero. By incorporating incomplete nuclear families, C-XPAT is more powerful than XPAT using only complete nuclear families. For practical use, these proposed methods are applied to analyse the rheumatoid arthritis data and Turner’s syndrome data.
A Virtual-grid farmland data-gathering locations decision algorithm for the mobile sink in wireless sensor network

The wireless sensor networks are applied to farmland for achieving unmanned agriculture and improving the grain production. The primary task is collecting the data of the deployed sensors using a mobile sink. This paper proposes a virtual-grid method to determine the visiting locations of the mobile sink in a farmland. The virtual grids with higher scores are selected as the candidate visiting locations. A redundant-locations elimination algorithm which uses set-conjunction operations is also proposed for reducing the unnecessary visiting locations. Simulation results show that the proposed virtual-grid method can effectively reduce the number of visiting locations about 15%-20% than the cluster-centroid method which uses the centroid position of a group deployed sensors as the visiting location for mobile sink.
Multiple Ligands of von Willebrand Factor-binding Protein (vWbp) Promote Staphylococcus aureus Clot Formation in Human Plasma*

Background: Staphylococcus aureus manipulates blood coagulation by secreting von Willebrand factor binding protein (vWbp) and coagulase. Results: vWbp forms a macromolecular complex with prothrombin, fibrinogen, factor XIII, and fibronectin. Conclusion: vWbp activates FXIII in a non-proteolytic manner and recruits fibronectin to staphylococcal clots. Significance: Activation of FXIII by vWbp represents a novel virulence strategy to promote formation of cross-linked fibrin cables in human plasma. Staphylococcus aureus secretes coagulase (Coa) and von Willebrand factor-binding protein (vWbp) to activate host prothrombin and form fibrin cables, thereby promoting the establishment of infectious lesions. The D1-D2 domains of Coa and vWbp associate with, and non-proteolytically activate prothrombin. Moreover, Coa encompasses C-terminal tandem repeats for binding to fibrinogen, whereas vWbp has been reported to associate with von Willebrand factor and fibrinogen. Here we used affinity chromatography with non-catalytic Coa and vWbp to identify the ligands for these virulence factors in human plasma. vWbp bound to prothrombin, fibrinogen, fibronectin, and factor XIII, whereas Coa co-purified with prothrombin and fibrinogen. vWbp association with fibrinogen and factor XIII, but not fibronectin, required prothrombin and triggered the non-proteolytic activation of FXIII in vitro. Staphylococcus aureus coagulation of human plasma was associated with the recruitment of prothrombin, FXIII, and fibronectin as well as the formation of cross-linked fibrin. FXIII activity in staphylococcal clots could be attributed to thrombin-dependent proteolytic activation as well as vWbp-mediated non-proteolytic activation of FXIII zymogen.
Structuring and imaging for road sites in urban traffic accident

Road site is the main static part of traffic accident scene, which needs to be well imagined for rapidly accidents disposing and reconstruction. Taken urban road site as study object, it classified urban road sites and analyzed their elements makeup. After studied urban road sites elements characteristics, structural parameters, attribute parameters and position parameters of every element were given detail. With discussed of MATLAB environments setup, a new method imaging road site information by MATLAB was achieved based on above structuring works. The method also was applied and realized with an example. The study indicates that the method for imaging urban road sites with MALAB is feasible and easy, with advantages of less developing workload and others.
Duplication of segment 1p21 following paternal insertional translocation, ins(6;1)(q25;p13.3p22.1)

A moderately mentally retarded 3 year old boy showed minor anomalies including a prominent forehead and flat occiput, exophthalmos, large and prominent ears, high arched palate, umbilical hernia, sacral dimple, and irregular position of the toes. Cardiac sonography disclosed a chorda running through the left ventricle. Cytogenetic investigation of the family showed a balanced insertional translocation of segment 1p13→p22 into distal 6q in the father which had led, through unbalanced segregation, to duplication of 1p13.3→p22.1 in the proband. Familial duplication of such a small interstitial segment of 1p has not been reported previously, and the paucity of abnormal physical findings in the proband compared to previous patients with a similar aberration is remarkable.
A clinical method to assess the effect of visual loss on the ability to perform activities of daily living

Background/aims To develop a clinically applicable, performance-based measure of the ability to perform visually related activities. Methods 99 patients with glaucoma and 21 subjects with a normal ocular examination completed a nine-item performance-based test (the Assessment of Ability Related to Vision (AARV)), received a standard ophthalmic clinical examination and answered the questions on the National Eye Institute's Visual Functioning Questionnaire (NEI-VFQ-25). All combinations of two, three or four items of the full nine-item AARV test were analysed, and their scores were compared with the full AARV scores and with clinical measures. Results The correlation of four items (detecting motion, reading signs, finding objects and navigating an obstacle course) reduced test time from 60±5 min to 14±4 min and yielded results highly related to the nine-item test, including maintaining the relationship with clinical measures and with the NEI-VFQ-25. Conclusion A compressed AARV correlates highly with the full test, with a method of evaluating quality of life, and with clinical measures, yet takes on average 14 min to perform. As such, it may provide a clinically useful method of evaluating the worsening effects of illness and the benefits of treatments that affect visual loss on the ability to perform visually related activities.
Rearing the Sad or Mad: Differentiating the Family Environments of Depressed Versus Conduct Disordered Youth

The following review examines the current literature on parental depression and its characteristic family environment and parenting styles that may be related to the development of Conduct Disorder (CD) or depression in children. A description of the depressed parent and the general effects of depression on parenting and discipline practices are discussed. Studies on the relationship between parental depression and child psychopathology are reviewed. The family environment variables related to CD are discussed as well as the commonalities between families with depressed children and those with disruptive behavior disorders.
Determinants of Antileukemia Effects of Allogeneic NK Cells 1

In HLA-nonidentical bone marrow transplantation, we studied the characteristics of donor NK cells, recipient leukemia cells, and the cytokine environment that predict the antileukemia effects of allogeneic NK cells. We found that the risk of relapse in pediatric patients with hematologic malignancies was best predicted by a model taking into consideration the presence of inhibitory killer cell Ig-like receptors (KIRs) on the donor’s NK cells and the absence of corresponding KIR ligand in the recipient’s HLA repertoire (a receptor-ligand model). The risk of relapse was prognosticated less precisely by the Perugia donor-recipient KIR ligand-ligand mismatch model or by a natural cytotoxicity model. In contrast to the ligand-ligand model, we found that the new receptor-ligand model was accurate when analysis was applied to patients with lymphoid malignancy. These findings corroborate our observations that the recipient’s KIR repertoire, which was derived from highly purified, HLA-disparate CD34+ cells, resumed a donor-specific pattern within 3 mo of transplantation, but did not correlate evidently with the donor or recipient ligand repertoire. In an in vitro assay and an in vivo mouse model, human NK cell cytotoxicity toward human leukemia cells with 11q23 chromosomal rearrangement increased with the number of receptor-ligand mismatch pairs or prestimulation with IL-12 and IL-18. These findings provide new insights into the determinants of antileukemia effects of allogeneic NK cells and therapeutic strategies.
Advanced lung cancer in the older patient: is there a role for bevacizumab?

There is ongoing discussion about the most appropriate treatment for lung cancer in elderly patients. Many trials exclude this age group; and those that include elderly, often do not distinguish between age groups. The advent of targeted agents in cancer therapy has raised the hope that older cancer patients could be treated as effectively as younger patients and without added toxicities.
N 6-methyladenosine modification and the YTHDF 2 reader protein play cell type 1 specific roles in lytic viral gene expression during Kaposi ’ s sarcoma-associated 2 herpesvirus infection 3 4

18 Methylation at the N 6 position of adenosine (m 6 A) is a highly prevalent and reversible 19 modification within eukaryotic mRNAs that has been linked to many stages of RNA processing 20 and fate. Recent studies suggest that m 6 A deposition and proteins involved in the m 6 A pathway 21 play a diverse set of roles in either restricting or modulating the lifecycles of select viruses. 22 Here, we report that m 6 A levels are significantly increased in cells infected with the oncogenic 23 human DNA virus Kaposi’s sarcoma-associated herpesvirus (KSHV). Transcriptome-wide m 6 A24 sequencing of the KSHV-positive renal carcinoma cell line iSLK.219 during lytic reactivation 25 revealed the presence of m 6 A across multiple kinetic classes of viral transcripts, and a 26 concomitant decrease in m 6 A levels across much of the host transcriptome. However, we found 27 that depletion of the m 6 A machinery had differential proand anti-viral impacts on viral gene 28 expression depending on the cell-type analyzed. In iSLK.219 cells the pathway functioned in a 29 pro-viral manner, as depletion of the m 6 A writer METTL3 and the reader YTHDF2 significantly 30 impaired viral lytic cycle progression and virion production. This defect could be attributed to 31 their roles in the post-transcriptional accumulation of the major viral lytic transactivator ORF50, 32 which is m 6 A modified. In contrast, although the ORF50 mRNA was also m 6 A modified in KSHV 33 infected B cells, ORF50 expression was instead increased upon depletion of METTL3, YTHDF1, 34 or, to a lesser extent, YTHDF2. These results highlight that the m 6 A pathway is centrally 35 involved in regulating KSHV gene expression, and underscore how the outcome of this 36 dynamically regulated modification can vary significantly between cell types. 37 . CC-BY-NC-ND 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not . http://dx.doi. org/10.1101/201475 doi: bioRxiv preprint first posted online Oct. 11, 2017;