Miracle-dz/UniFAR-FTUs huggingface dataset:
Fever control using external cooling in septic shock.

shock (1). This clinical trial adds further evidence to the growing efforts to define an evidence-based approach to fever control in critically ill patients. They found that external cooling with a cooling blanket or cold bed sheets and ice packs was strongly associated with (1) a decrease in the dose of vasopressor required to maintain a mean arterial pressure of at least 65 mm Hg at 12 and 24 hours after randomization; and (2) a decrease in early (14-d) mortality in febrile patients with septic shock. This beneficial impact on early mortality was not maintained upon discharge from the intensive care unit (ICU), or hospital, and contrasts with previous observational studies and clinical trials investigating the effects of antipyretic therapy among adult patients admitted to ICUs (2–4). These previous investigations found fever control with pharmacologic and/or physical antipyretic therapy had either neutral (2) or harmful (3, 4) effects on mortality. This discrepancy may be a result of differences in the study populations (septic shock vs. cohorts of general critically ill patients), the chosen antipyretic modality (external cooling vs. pharmacologic therapy), the timing of fever control, and/or important cointerventions. In our experience, controlling for cointervention with other antipyretic therapy is an important component to any clinical trial investigating fever control strategies (5). This was a major issue in a double-blind study comparing ibuprofen to placebo in patients with sepsis (2), and is potentially even more important in an openlabel study such as the Sepsiscool trial (1). Furthermore, two recently published cohort studies suggest that the majority of febrile critically ill patients receive some form of antipyretic therapy often without an explicit order to guide this management strategy (4, 6). The authors of the Sepsiscool trial did not explicitly indicate how pharmacologic antipyretic therapy was regulated among study participants during the treatment period, nor did they outline the antipyretic modalities applied to study participants that developed a fever after completing the 48-hour treatment period. This information may help to explain why unlike previous studies, external cooling reduced early mortality but not that upon discharge from the ICU.
3D CNN based phantom object removing from mobile laser scanning data

In this paper we introduce a new deep learning based approach to detect and remove phantom objects from point clouds produced by mobile laser scanning (MLS) systems. The phantoms are caused by the presence of scene objects moving concurrently with the MLS platform, and appear as long, sparse but irregular point cloud segments in the measurements. We propose a new 3D CNN framework working on a voxelized column-grid to identify the phantom regions. We quantitatively evaluate the proposed model on real MLS test data, and compare it to two different reference approaches.
An improved on-line neural network controller for multi-variable control of UPFC

This paper proposes an improved on-line neural network (OLNN) controller by incorporating changes in neural network architecture of indirect-inverse identification neural network controller (IIINNC), which was proposed earlier for controlling power flow, AC bus and DC link voltages of unified power flow controller (UPFC). A new learning algorithm has been derived for the proposed OLNN controller. The proposed OLNN controller requires less training and validation compared to that of the IIINNC. The architecture and control algorithm of the proposed neural controller reduces the complexity and latency time in comparison to the IIINNC. Simulation studies carried out demonstrates the applicability of the proposed on-line neural controller for the multi-variable control of UPFC
Skeletal muscle involvement in human immunodeficiency virus (HIV)–infected patients in the era of highly active antiretroviral therapy (HAART)

Skeletal muscle involvement can occur at all stages of human immunodeficiency virus (HIV) infection, and may represent the first manifestation of the disease. Myopathies in HIV‐infected patients are classified as follows: (1) HIV‐associated myopathies and related conditions, including HIV polymyositis, inclusion‐body myositis, nemaline myopathy, diffuse infiltrative lymphocytosis syndrome (DILS), HIV‐wasting syndrome, vasculitic processes, myasthenic syndromes, and chronic fatigue; (2) muscle complications of antiretroviral therapy, including zidovudine and toxic mitochondrial myopathies related to other nucleoside‐analogue reverse‐transcriptase inhibitors (NRTIs), HIV‐associated lipodystrophy syndrome, and immune restoration syndrome related to highly active antiretroviral therapy (HAART); (3) opportunistic infections and tumor infiltrations of skeletal muscle; and (4) rhabdomyolysis. Introduction of HAART has dramatically modified the natural history of HIV disease by controlling viral replication, but, in turn, lengthening of the survival of HIV‐infected individuals has been associated with an increasing prevalence of iatrogenic conditions. Muscle Nerve, 2005
Correlation of Technetium-99 m-DISIDA Hepatobiliary Studies with Biopsies in Liver Transplant Patients

We compared 76 9~"Tc-DISIDA hepatobiliary studies with corresponding liver biopsies in 36 liver transplant patients to determine the histopathologic abnormalities that corresponded to scintigraphic abnormalities in uptake and excretion. Uptake was judged normal if the cardiac blood pool was barely visible or invisible on the ten minute image. Excretion was judged normal if images subsequent to the 15-min image showed a subjectively normal rate of decreasing parenchymal intensity. Biopsies were graded subjectively for hepatocyte damage and for findings of cholestasis. Uptake criteria were successful in differentiating high from low hepatocyte damage scores (p < 0.0001), and excretion criteria were successful in differentiating high from low cholestasis scores (p = 0.002), while uptake criteria were not capable of differentiating high from low cholestasis scores, nor were excretion criteria capable of differentiating high from low hepatocyte damage scores (p's > 0.05). These results suggest that scintigraphy can distinguish intrahepatic cholestasis from pure hepatocyte damage.
DNA replication and nuclear architecture

The model of in situ DNA replication provided by immunofluorescence and confocal imaging is compared with observations obtained by electron microscopic studies. Discrepancies between both types of observations call into question the replication focus as a persistent nuclear structure and as a replication entity where DNA replication takes place. Most electron microscopic analyses reveal that replication sites are confined to dispersed chromatin areas at the periphery of condensed chromatin, and the distribution of replication factors exhibits the same localization pattern. Moreover, rapid migration of newly synthesized DNA from the replication sites towards the interior of condensed chromatin regions obviously takes place during S‐phase. It implies modifications of replication domains, hardly detectable by fluorescence microscopy. The confrontation of different observations carried out at light microscopic or electron microscopic levels of resolution lead to a conclusion that a combination of in vivo fluorescence analysis with a subsequent ultrastructural investigation performed on the same cells will represent an optimal approach in future studies of nuclear functions in situ. J. Cell. Biochem. 85: 1–9, 2002. © 2002 Wiley‐Liss, Inc.
FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome.

To the Editor: The immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, a rare disorder characterized by multiorgan autoimmunity, often results in death in infancy.1 The IPEX syndrome results from mutations in the forkhead box P3 (FOXP3) gene, which encodes a transcriptional repressor considered to be the master regulator of differentiation in CD4+ regulatory T (Treg) cells.2,3 Multiple FOXP3 mutations resulting in a range of clinical outcomes have been characterized.1–3 Since neither genetic sequencing nor protein expression correlates reliably with clinical manifestations in the IPEX syndrome,4 identification of the functional consequences of individual mutations is critical to .
Neural network based spread spectrum PN code acquisition system

A neural network based direct sequence spread spectrum code synchronization system is proposed. The's system is based on training a recurrent random neural network (RNN) model on all the possible phases of the used spreading code. The trained network can then be used at the receiver for the initial coarse alignment of the local code phase and the received code. One advantage of this technique over the conventional synchronization techniques is that the phase of the received PN code can be decided without searching the potential code phases. Also the RNN, after being trained, can have a simple hardware realization that makes it candidate for implementation as a dedicated chip. This makes the neural network based technique faster and more robust than the conventional techniques. Computer simulations, carried out on maximal length sequences of length N=7 and N=15, show that the proposed system cast effectively indicate the phase of the received code even with very low signal to noise ratios.
A stator flux synthesis approach for torque estimation of induction motors using a modified stator resistance considering the losses effect

This work proposes a methodology for induction motor torque estimation based on the stator flux model. The presented methodology just relies on line voltages, line currents and nameplate data; and it adopts a modified stator resistance, which already comprises the mechanical losses effect. This modified stator resistance is estimated through a Particle Swarm Optimization (PSO) algorithm, which is a kind of artificial intelligence applied to optimization problems. The PSO presented objective function aims to minimize the torque error at the rated operation point. Simulation and experimental results validate the effectiveness of the presented methodology.
Depth Extraction from Monocular Video Using Bidirectional Energy Minimization and Initial Depth Segmentation

In this paper, we propose to extract depth information from a monocular video sequence. When estimating the depth of the current frame, the bidirectional energy minimization in our scheme considers both the previous frame and next frame, which promises a much more robust depth map and reduces the problems associated with occlusion to a certain extent. After getting an initial depth map from bidirectional energy minimization, we further refine the depth map using segmentation by assuming similar depth values in one segmented region. Different from other segmentation algorithms, we use initial depth information together with the original color image to get more reliable segmented regions. Finally, detecting the sky region using a dark channel prior is employed to correct some possibly wrong depth values for outdoor video. The experimental results are much more accurate compared with the state-of-the-art algorithms.
A Branch and Bound Algorithm for Feature Subset Selection

A feature subset selection algorithm based on branch and bound techniques is developed to select the best subset of m features from an n-feature set. Existing procedures for feature subset selection, such as sequential selection and dynamic programming, do not guarantee optimality of the selected feature subset. Exhaustive search, on the other hand, is generally computationally unfeasible. The present algorithm is very efficient and it selects the best subset without exhaustive search. Computational aspects of the algorithm are discussed. Results of several experiments demonstrate the very substantial computational savings realized. For example, the best 12-feature set from a 24-feature set was selected with the computational effort of evaluating only 6000 subsets. Exhaustive search would require the evaluation of 2 704 156 subsets.
Processus d’acquisition des clusters et autres séquences de consonnes en langue seconde : de l’analyse acoustico-perceptive des séquences consonantiques du vietnamien à l’analyse de la perception et production des clusters du français par des apprenants vietnamiens du FLE

Une des principales difficultes rencontrees par les Vietnamiens apprenants du francais langue etrangere, une des plus resistantes aux enseignements de phonetique corrective, est la prononciation des groupes consonantiques intra- ou inter-syllabiques, intra- ou inter-mots du francais. Quelles sont alors les veritables raisons de ces difficultes ? C'est a cette question que tente de repondre ce travail d'etude doctorale. La these aborde une problematique qui s'inscrit dans le cadre de recherches sur les capacites a percevoir les gestes de l'autre puisque des travaux recents montrent que la capacite a retrouver les caracteristiques du controle des gestes des articulateurs passe par la perception du signal qui encode ces gestes. Dans ce cadre theorique liant perception et action et a partir d'une comparaison des sequences consonantiques dans les deux langues en prenant en compte la notion de syllabe, il s'est agi d'identifier et expliquer un ensemble de facteurs acoustico-perceptifs et articulatoires responsables de la difficulte a realiser les groupes consonantiques du francais par des apprenants vietnamiens. La these propose un ensemble de resultats tout a fait interessants qui sont discutes a la lumiere des differentes theories et modeles d'acquisition des sons des langues etrangeres. Ces resultats pourront trouver application dans le developpement d'un outil de technologie educative pour l'apprentissage du francais par des Vietnamiens (et sur une echelle d'application plus large pour l'apprentissage des langues en general) capable de proposer des protocoles en phonetique corrective tels que strategies de recuperation des gestes (entrainements) et evaluation des performances des apprenants.
A Mechanism of COOH–Terminal Binding Protein–Mediated Repression

The E2F4 and E2F5 proteins specifically associate with the Rb-related p130 protein in quiescent cells to repress transcription of various genes encoding proteins important for cell growth. A series of reports has provided evidence that Rb-mediated repression involves both histone deacetylase (HDAC)–dependent and HDAC-independent events. Our previous results suggest that one such mechanism for Rb-mediated repression, independent of recruitment of HDAC, involves the recruitment of the COOH-terminal binding protein (CtBP) corepressor, a protein now recognized to play a widespread role in transcriptional repression. We now find that CtBP can interact with the histone acetyltransferase, cyclic AMP–responsive element–binding protein (CREB) binding protein, and inhibit its ability to acetylate histone. This inhibition is dependent on a NH2-terminal region of CtBP that is also required for transcription repression. These results thus suggest two complementary mechanisms for E2F/p130-mediated repression that have in common the control of histone acetylation at target promoters.
Genetic and environmental factors in age-related nuclear cataracts in monozygotic and dizygotic twins.

BACKGROUND Age-related cataracts are a major public health problem. The relative importance of genes and environment in the causation of nuclear cataracts, the most common form of age-related cataracts, is not known. METHODS We studied 506 pairs of female twins (226 monozygotic and 280 dizygotic) who were 50 to 79 years old (mean, 62). The amount of nuclear cataract in the right and left eyes was determined objectively by analysis of Scheimpflug lens photographs (yielding three measures) and subjectively with use of the Oxford Clinical Cataract Classification and Grading System (yielding one measure). All eight measures (four in each eye) were subsequently combined in one summary measure of nuclear cataract for each woman. A univariate maximum-likelihood model was used to estimate the variance of the genetic and environmental contributions to each of the measures. RESULTS The different measures of cataract formation were highly correlated (correlation coefficients, 0.71 to 0.94). The mean scores were similar for the right and left eyes and for monozygotic and dizygotic twins. Quantitative genetic modeling of each of the nuclear-cataract scores invariably resulted in a best-fitting model that involved additive genetic effects, unique environmental effects, and age. The common environmental and dominant genetic effects could be removed from the models without significant loss of fit. The overall heritability in the combined nuclear-cataract score (the proportion of the variance explained by genetic factors) was 48 percent (95 percent confidence interval, 42 to 54 percent); age accounted for 38 percent of the variance (95 percent confidence interval, 31 to 44 percent) and unique environmental effects for 14 percent (95 percent confidence interval, 12 to 18 percent). CONCLUSIONS Genetic effects are important even in such a clearly age-related disease as nuclear cataract, explaining almost 50 percent of the variation in the severity of this disease.
Discontinuation of statin therapy in older people: does a cancer diagnosis make a difference? An observational cohort study using data linkage

Objective The aim was to examine statin discontinuation rates in a cohort of elderly Australians with newly diagnosed cancer using population-based secondary health data. Design Observational cohort study. Setting New South Wales, the largest jurisdiction in Australia. The Pharmaceutical Benefits and Repatriation Pharmaceutical Benefits Schemes are national programmes subsidising prescription drugs to the Australian population and Australian Government Department of Veterans' Affairs clients. Participants The cohort comprised 1731 cancer patients aged ≥65 years with evidence of statin use in the 90 days prior to diagnosis. They were matched to 3462 non-cancer patients prescribed statins in the same period. Main outcome measure The authors compared statin discontinuation rates up to 4 years post-diagnosis and examined the factors associated with statin discontinuation. Results The proportion of cancer patients discontinuing statin therapy at 4 years (27%) was comparable to the comparison cohort; however, significantly higher proportions of the cancer cohort discontinued statins than the comparison cohort at 3, 6 and 12 months of follow-up (9.7% vs 7.4% at 12 months, respectively). More than 30% of cancer patients who died were dispensed statins within 30 days of death. Discontinuation of statin therapy in cancer patients was associated with regionalised and distant disease spread at diagnosis (p<0.001), older age (p=0.006), upper gastrointestinal organs and liver cancer (aHR 2.95, 95% CI 1.92 to 4.53) and cancer of the lung, bronchus and trachea (aHR 1.99, 95% CI 1.32 to 3.00) and poorer survival. Conclusions Medications should be rationalised at the time of a cancer diagnosis, especially in the setting of a poor prognosis. At least for some patients in our cohort, statin therapy may be inappropriately continued which adds unnecessarily to therapeutic burden.
USE 1 is a bispecifi c conjugating enzyme for ubiquitin and FAT 10 , which FAT 10 ylates itself in cis

The ubiquitin-like modifi er FAT10 targets proteins for degradation by the proteasome and is activated by the E1 enzyme UBA6. In this study, we identify the UBA6-specifi c E2 enzyme (USE1) as an interaction partner of FAT10. Activated FAT10 can be transferred from UBA6 onto USE1 in vitro , and endogenous USE1 and FAT10 can be coimmunoprecipitated from intact cells. Small interfering RNA-mediated downregulation of USE1 mRNA resulted in a strong reduction of FAT10 conjugate formation under endogenous conditions, suggesting that USE1 is a major E2 enzyme in the FAT10 conjugation cascade. Interestingly, USE1 is not only the fi rst E2 enzyme but also the fi rst known substrate of FAT10 conjugation, as it was effi ciently auto-FAT10ylated in cis but not in trans .
The effect of national and international R&D cooperation: differences between manufactures and services

Using data from the Spanish survey of technological innovation, this paper analyses differences between service and manufacturing firms regarding the impact of national and international R&D cooperation on firms' innovative performance. Results indicate that industrial innovative activity mostly benefits from collaboration at the national level, while international cooperation is crucial for services. Results also show that services are able to combine both national and international partners in an advantageous way, while manufacturing firms that are simultaneously involved in national and international partnerships do not have a greater innovative performance than those that are not involved in R&D collaboration at all.
Sigma factor phosphorylation in the photosynthetic control of photosystem stoichiometry

An imbalance in photosynthetic electron transfer is thought to be redressed by photosynthetic control of the rate of expression of genes encoding apoproteins of photosystem (PS)-I and PS-II in response to the redox state of plastoquinone (PQ), which is a connecting electron carrier. PS stoichiometry is then adjusted to enhance photosynthetic efficiency. In prokaryotes, sigma factors are well known for their participation in the control of RNA polymerase activity in transcription, whereas there have been no reports concerning their association with redox regulation. We have found that the phosphorylation of SIG1, the major sigma factor (SIG), is regulated by redox signals and selectively inhibits the transcription of the psaA gene, which encodes a PS-I protein. We produced transgenic Arabidopsis plants with or without the putative phosphorylation sites for SIG1 and demonstrated through in vivo labeling that Thr-170 was involved in the phosphorylation. We analyzed the in vivo and in vitro transcriptional responses of the transgenic Arabidopsis plants to the redox status in regard to involvement of the phosphorylation site. We revealed an enhanced phosphorylation of SIG1 under oxidative conditions of PQ in a form associated with the molecular mass of the holoenzyme. Phosphorylation of SIG1 proved crucial through a change in the promoter specificity for sustaining balanced expression of components in PS-I and PS-II and was responsible for harmonious electron flow to maintain photosynthetic efficiency.
Hybrid Particle Swarm-Based-Simulated Annealing Optimization Techniques

Particle swarm optimization (PSO) algorithms recently invented as intelligent optimizers with several highly desirable attributes. In this paper, two new hybrid particle swam optimization schemes are proposed. The proposed hybrid algorithms are based on using the particle swarm optimization techniques in conjunction with the simulated annealing (SA) approach. By simulating three different test functions, it is shown how the proposed hybrid algorithms offer the capability of converging toward the global minimum or maximum points. More importantly, the simulation results indicate that the proposed hybrid particle swarm-based simulated annealing approaches have much superior convergence characteristics than the previously developed PSO methods