Miracle-dz/UniFAR-FTUs huggingface dataset:
A comprehensive study on the degradation of lithium-ion batteries during calendar ageing: The internal resistance increase

Lithium-ion batteries are regarded as the key energy storage technology for both e-mobility and stationary renewable energy storage applications. Nevertheless, the Lithium-ion batteries are complex energy storage devices, which are characterized by a complex degradation behavior, which affects both their capacity and internal resistance. This paper investigates, based on extended laboratory calendar ageing tests, the degradation of the internal resistance of a Lithium-ion battery. The dependence of the internal resistance increase on the temperature and state-of-charge level have been extensive studied and quantified. Based on the obtained laboratory results, an accurate semi-empirical lifetime model, which is able to predict with high accuracy the internal resistance increase of the Lithium-ion battery over a wide temperature range and for all state-of-charge levels was proposed and validated.
Quality of life in a Brazilian sample of patients with Parkinson's disease and their caregivers.

OBJECTIVE Parkinson's disease is a common neurodegenerative disorder characterized by motor disabilities and increasing dependence on others for daily life activities with consequent impact on patients' and caregivers' quality of life. METHOD A cross-sectional study was performed in which quality of life was assessed by the WHOQOL-BREF questionnaire in 21 patients with Parkinson's disease and their respective caregivers. RESULTS Significant differences between patients and caregivers were found in physical (p < 0.001) and psychological (p = 0.002) domains. In the Parkinson's disease group there was a significant inverse correlation between the psychological domain and duration of disease (p = 0.01), as well as between social domain and severity of disease (p = 0.001). There was a positive correlation between physical domain scores and number of people living in the same house (p = 0.02). The only significant finding in the group of caregivers was an inverse correlation between the social domain and the patients' age (p = 0.04). CONCLUSION Duration, severity of the disease and the number of people living in the same house were the most important predictors of quality of life of Parkinson's disease patients. The age of the patients was the only significant predictor found in the caregivers' quality of life. In order to complement our findings, further short-form questionnaires should be validated for Brazilian samples of Parkinson's disease.
ÁREAS METROPOLITANAS EN EXPANSIÓN: HACIA LA BÚSQUEDA DE LA INTEGRACIÓN ENTRE LA “CIUDAD TRADICIONAL” Y LOS NUEVOS ARCHIPIÉLAGOS URBANOS.

Las grandes areas metropolitanas de Latinoamerica presentan, a comienzos del siglo XXI, procesos cada vez mas acelerados de dispersion urbana. Este crecimiento de los territorios urbanizados, en su devenir, va generando un movimiento centrifugo, que esparce “retazos de ciudad”, en archipielagos pseudo-urbanos en medio de entornos rurales. En la region metropolitana de Buenos Aires (RMBA), se observa que su expansion no solo fragmenta los territorios, sino tambien el entramado social. Del tejido inclusivo tentacular que fue configurando este espacio desde mediados del siglo XX mediante la suburbanizacion de los sectores populares, a la suburbanizacion insular de sectores medio altos que se autoexcluyeron en enclaves de lujo en los ’90, hay un cambio de paradigma. Podemos afirmar que mientras las condiciones de movilidad han promovido la integracion de municipios perifericos con la ciudad central, al interior de los mismos, esa movilidad se transformo en un factor de diferenciacion de clases sociales con respecto al acceso a algo que deberia ser inherente a todos los habitantes: el derecho a la ciudad. Por ende, nos focalizaremos sobre la sub-region sur de la RMBA, que en los ultimos tiempos ha recibido numerosos desarrollos privados, mientras experimento una activa dinamica de crecimiento en las localidades existentes; remarcando que se vislumbra una relacion dialectica de integracion/exclusion entre la urbanizacion privada y las localidades pre-existentes. Cabe preguntarse, entonces, acerca de las estrategias a implementar para repensar la integracion socio-territorial de estos escenarios y para discutir politicas que aborden la problematica comun del desarrollo urbano con equidad e inclusion.
Analysis of Adoption Processes in Industry 4.0

Nowadays digitalization is changing manufacturing and work in many companies. A keyword for the linkage between production systems and information and communication technology is the term Industry 4.0. Industry 4.0 affects the whole working environment and requires a cultural change of the organization. Currently many technological solutions are available because much research from an engineering perspective has already driven this topic. However, firms still struggle to implement this vision into their strategy. Companies need to know how to design and execute human centered decision processes. Thus, it is important to understand adoption processes to identify needs for action and prevent failures. Socio-technical perspectives are necessary to consider technological, human and organizational aspects. This position paper has the aim to show the need for research in this topic and present a research plan to solve this problem.
An Examination of Stage Theory of Grief among Individuals Bereaved by Natural and Violent Causes: A Meaning-Oriented Contribution

Despite its popularity, few attempts have been made to empirically test the stage theory of grief. The most prominent of these attempts was conducted by Maciejewski, Zhang, Block, and Prigerson (2007), who found that different states of grieving may peak in a sequence that is consistent with stage theory. The present study aimed to provide a conceptual replication and extension of these findings by examining the association between time since loss and five grief Indicators (focusing on disbelief, anger, yearning, depression, and acceptance), among an ethnically diverse sample of young adults who had been bereaved by natural (n = 441) and violent (n = 173) causes. We also examined the potential salience of meaning-making and assessed the extent to which participants had made sense of their losses. In general, limited support was found for stage theory, alongside some evidence of an “anniversary reaction” marked by heightened distress and reduced acceptance for participants approaching the second anniversary of the death. Overall, sense-making emerged as a much stronger predictor of grief Indicators than time since loss, highlighting the relevance of a meaning-oriented perspective.
Effective OHT dispatching for differentiated material handling services in 300mm wafer foundry

This paper tackles the problem of providing differentiated material handling services in a highly automated environment of 300mm wafer foundry manufacturing. A preemptive dispatching policy is proposed and studied to expedite the movement of high priority products while keeping the incurred delays on regular ones being acceptable. Simulation experiments based on realistic data from a local 300mm foundry fab are conducted. Numerical results demonstrate that the proposed policy is sound in reducing the transport delay of high priority products to the extreme. Some features of the policy are also explored.
LA FONDATION DES MACHINES MODERNES, DES DESSINS.

De nos jours, les industries de masse peuvent designer sur le papier une machine compliquee, telle qu'un moteur d'automobile, et ensuite en produire un million de copies conformes. La these de cet article est qu'apres l'invention de l'imprimerie, aucune etape particulierement revolutionnaire n'a permis cette capacite de production que nous connaissons aujourd'hui. Au contraire, ce resultat remarquable s'explique plutot par une serie d'humbles changements qui ont progressivement modifie la facon dont les connaissances etaient clarifiees et transmises sur le papier. Au cours des XVII e et XIX e siecles, un nombre de plus en plus important de repertoires classant les types de machines selon de grandes categories vit le jour. Des dessins plus specialises expliquant en detail comment les machines devaient etre executees rendirent possible la centralisation des procedes de fabrication. La maitrise d'une production de masse extremement complexe reposait sur la transformation progressive de l'organisation du travail dans les ateliers, organisation qui se trouvait rendue possible par des dessins et des mots inscrits sur du papier.
Schizophrénie et toxicomanie : l’héritage du psychiatre Jean-Yves Roy

Cher Jean-Yves, le 27 avril 2004, tu nous as quitte sur la pointe des pieds, laissant inacheves des projets de recherche portant sur la comorbidite schizophrenie — toxicomanie, que nous avons eu l’occasion de completer au cours des dernieres annees au Centre de recherche Fernand-Seguin. Ce sont ces developpements que nous souhaitons ici te raconter. Nous te presentons d’abord une serie de travaux qui evaluent la validite de l’hypothese de l’automedication, impliquant diverses techniques scientifiques (meta-analyse, imagerie cerebrale et neuropsychologie). Les resultats de ces travaux suggerent fortement que les patients souffrant a la fois de schizophrenie et de toxicomanie ont moins de symptomes negatifs et de deficits cognitifs que les patients non toxicomanes. Ils presentent toutefois davantage de symptomes extrapyramidaux. En particulier, les resultats montrent que les patients avec un double diagnostic ont moins d’anhedonie, ce qui place la notion de plaisir au coeur de l’enjeu de la comorbidite, comme tu l’anticipais justement. Nous presentons ensuite les resultats preliminaires d’une etude ouverte qui suggere un potentiel effet benefique de la quetiapine chez les patients schizophrenes et toxicomanes, une etude qui nous egalement permis, comme tu l’esperais, de mettre en lumiere des relations intrigantes entre les cannabinoides endogenes, les cytokines, la schizophrenie et la toxicomanie. Le caractere prometteur de ces resultats a fait en sorte que nous venons d’obtenir un financement ou nous pourrons evaluer, dans les memes conditions et selon les memes parametres, des patients schizophrenes non toxicomanes et des patients toxicomanes qui ne souffrent pas d’un trouble psychotique.
Making Efficient Use of a Domain Expert's Time in Relation Extraction

Scarcity of labeled data is one of the most frequent problems faced in machine learning. This is particularly true in relation extraction in text mining, where large corpora of texts exists in many application domains, while labeling of text data requires an expert to invest much time to read the documents. Overall, state-of-the art models, like the convolutional neural network used in this paper, achieve great results when trained on large enough amounts of labeled data. However, from a practical point of view the question arises whether this is the most efficient approach when one takes the manual effort of the expert into account. In this paper, we report on an alternative approach where we first construct a relation extraction model using distant supervision, and only later make use of a domain expert to refine the results. Distant supervision provides a mean of labeling data given known relations in a knowledge base, but it suffers from noisy labeling. We introduce an active learning based extension, that allows our neural network to incorporate expert feedback and report on first results on a complex data set.
Topical Therapies in Inflammatory Bowel Disease

Due to misunderstandings about their effectiveness and feasibility, topical (or rectal) therapies with aminosalicylates (5-aminosalicylic acid, 5-ASA) and steroids are often underused in patients with ulcerative colitis (UC). However, many of these patients could be treated solely with rectal/topical therapies, or could benefit from them in combination with oral therapies. We review the evidence for topical therapies containing 5-ASA and budesonide in UC and discuss how these therapies can be optimized in daily practice, thereby improving compliance. Finally, we provide a brief summary of studies on the use of other topical treatments in UC, the results of which were both promising and negative.
Characteristics of proteinuria in experimental diabetes mellitus.

An impairment of protein charge selectivity has been invoked to explain the initial anionic proteinuria in diabetic nephropathy. The aims of this work were to investigate charge and size protein perm-selectivity abnormalities in experimental diabetes and to monitor these changes over time after diabetes induction. Diabetes was induced in 56 Sprague-Dawley male rats by streptozotocin; the control group was represented by 38 normal rats. Blood glucose, body weight, urine volumes, and proteinuria in 24-h urine collections were evaluated at 3, 6, 9, and 12 months of diabetes. The Bradford method and mono- and bidimensional gel electrophoresis were used to determine and characterize proteinuria. Body weight increase was lower (P < 0.05, P < 0.0001, P < 0.05 at 3, 6, and 12 months, respectively), urine volumes were greater (P < 0.001, P < 0.005, P < 0.05 at 6, 9, and 12 months, respectively) and the proteinuria was significantly increased (P < 0.05 at 3 months, P < 0.001 at 6 months, P < 0.01 at 9 months, and P < 0.05 at 12 months) in diabetic rats compared with the control group. When the charge and the size of urine proteins were considered, small (30 kDa) and anionic proteins were found to be mainly excreted in diabetic rats, at 3 months of the disease; at 6 months, higher amounts of albumin and cationic proteins with higher molecular weight (50 kDa) were also found in the urine; at 9 and 12 months the changes previously described were associated with an excretion of proteins weighing about 75 kDa. (ABSTRACT TRUNCATED AT 250 WORDS)
Acidentes vasculares cerebrais de repetição como manifestação de arterite de células gigantes Relapsing strokes as a manifestation of giant-cell arteritis

Resumo A arterite de celulas gigantes e uma vasculite que atinge arterias de grande e medio calibre, preferencialmente a aorta e os seus ramos cranianos, o que explica alguns dos seus sintomas classicos (amaurose, claudicacao da mandibula). Sao, no entanto, de esperar outras manifestacoes, pelo que os autores apresentam dois casos clinicos onde a suspeicao diagnostica foi levantada pelos acidentes vasculares cerebrais de repeticao, associados a elevacao sustentada de varios parâmetros inflamatorios. Palavras chave: arterite de celulas gigantes, vasculite, acidentes vasculares cerebrais de repeticao, reaccao inflamatoria sistemica, terapeutica.
Mechanisms of Hepatitis B Virus Resistance Development

Hepatitis B virus (HBV) resistance to nucleos(t)ide analogue (NA) therapy is essentially structure specific, with each NA falling within three main structural groups. Resistance to each of these is characterized by specific mutations in the reverse transcriptase domains of the HBV polymerase, and may be associated with compensatory mutations which can increase replication. HBV polymerase is considered to have a traditional ‘right-handed' structural conformation, and each of the resistance mutations is predicted to cause a specific structural change of the polymerase, thereby preventing incorporation of NA into replicating DNA. The selection of resistance occurs at different rates for each NA, and is affected by the high mutational rate of HBV and the ability of the drug to suppress viral replication. Some mutations or combinations of mutations may be associated with multidrug resistance, limiting treatment options. In contrast to most other viruses, resistance in HBV is confounded by the overlapping surface gene, the major NA-resistant mutations also altering the surface proteins in most cases, potentially altering virus secretion and neutralization, which may pose a public health threat in the future.
An improved biomedical edge detection based on dynamic subtraction method

In recent times, biomedical imaging & medical image processing have become magnificent beneficial and most challenging area of engineering & technology. X-ray, MRI CT gave wide variety of information for the anatomy, it recognize disease easily and clearly and it is also gave benefit and useful for exact diagnosis. Image segmentation is an imperative stride for further post-handling of therapeutic images. This paper gave the explanation the field of picture preparing and gives insights about how picture division procedures might be pertinent to the diverse imaging modalities accessible. On account of MRI of mind, picture division constitutes a fundamental stride for discovery of tumor. This paper gives a proposed technique that have been connected to cerebrum MRI images, CT images and X-ray image, to portion the mind into its constituent parts, including the tumor (if present).
Skin‐derived Precursors as a Source of Progenitors for Cutaneous Nerve Regeneration

Peripheral nerves have the potential to regenerate axons and reinnervate end organs. Chronic denervation and disturbed nerve regeneration are thought to contribute to peripheral neuropathy, pain, and pruritus in the skin. The capacity of denervated distal nerves to support axonal regeneration requires proliferation by Schwann cells, which guide regenerating axons to their denervated targets. However, adult peripheral nerve Schwann cells do not retain a growth‐permissive phenotype, as is required to produce new glia. Therefore, it is believed that following injury, mature Schwann cells dedifferentiate to a progenitor/stem cell phenotype to promote axonal regrowth. In this study, we show that skin‐derived precursors (SKPs), a recently identified neural crest‐related stem cell population in the dermis of skin, are an alternative source of progenitors for cutaneous nerve regeneration. Using in vivo and in vitro three‐dimensional cutaneous nerve regeneration models, we show that the SKPs are neurotropic toward injured nerves and that they have a full capacity to differentiate into Schwann cells and promote axon regeneration. The identification of SKPs as a physiologic source of progenitors for cutaneous nerve regeneration in the skin, where SKPs physiologically reside, has important implications for understanding early cellular events in peripheral nerve regeneration. It also provides fertile ground for the elucidation of intrinsic and extrinsic factors within the nerve microenvironment that likely play essential roles in cutaneous nerve homeostasis. STEM Cells2012;30:2261–2270
Tuberculosis treatment delivery in Bali: a qualitative study of clinic staff perceptions.

SETTING Little is known about the challenges of delivering tuberculosis (TB) treatment in Indonesia's southern province of Bali. OBJECTIVE We aimed to explore staff perceptions of TB treatment delivery and barriers to improved TB control in Bali to inform strategies for programme development. DESIGN Semi-structured interviews were conducted with staff who were involved in the delivery of TB treatment services in the public sector. RESULTS The main issues perceived by staff to influence TB treatment delivery include: the low level of community awareness of TB; delays to treatment seeking and the frequent use of private treatment providers; diagnostic difficulties; non-adherence to treatment; and a low level of staff education specific to TB. CONCLUSION Staff perceived a number of significant barriers to the early diagnosis and successful treatment of TB in Bali. The development of strategies to address these identified difficulties in TB control is essential to support improved programme effectiveness and enhanced TB control in Bali.
CELEBRATING FAY FRANSELLA'S 80 th YEAR

First of all, I’d like to thank Fay very much for inviting me to speak. I just want to explain a little bit about how PCP developed for me over the years. When I was younger I used to hear people talking, articulating differently about ‘reality’ with such certainty, what was right, what was wrong, morality, political, social. It did seem very confusing to me, they seemed to be talking about different realities. When I was a young whippersnapper, I had several experiences in the middle of the night – which were not induced by any substances – which have informed me ever since, which has not been explained by anything. It was like having an altered state of consciousness, everything seemed awesomely strange, like I was a stranger in a strange world. It was like looking from a nothingness into a somethingness. As far as the world was concerned it seemed strange that anything exists, not just the world, but my own consciousness. And through these experiences I realised that even our most advanced human knowledge compared to this vast awesomeness was very limited. Beyond was an ontological, fundamental mystery. Later, much later, when I read the question “why is there something rather than nothing”, it made a lot of sense to me. So I began to search in my own way to find frameworks that touched on this experience, for years, looking for elements of these, which I realise now I was looking for a range of convenience, a range of fit, but nothing really explained it. I used to read all sorts of things like existentialism (Macquarrie, 1972), phenomenological sociology (Berger & Luckmann, 1966) – which talked about multiple realities, Tibetan Buddhism (David-Neel & Larma, 1967), works on altered states of consciousness (Brown, 1986, Chilton Pearce, 1971/2002, Grof, 1985, Kaku, 1994, tart, 1988, 1990) and anything else which seemed potentially related (Polanyi, 1958, 1969. When as a mature student I did a psychology degree course. Then, when I was looking in a bookshop, one day, I came across the book Inquiring Man by Don Bannister and Fay Fransella (1971/1993) – which was not on the course reading. I realised that here was a psychology which fitted with multiple realities, and which recognised how human beings are configured and located. I at that time was always looking at meaning and I found Osgood’s Semantic Differential (Osgood, Suci & Tannenbaum, 1957), which I was quite interested in, but when I came across Kelly’s Repertory Grid (Kelly, 1955) which worked with a person’s own elicited meaning, this seemed better. After I finished the degree course I saw a PCP foundation course at the Royal Free, run by Fay, and realised this was the psychotherapy that I wanted to do. Later the advanced course developed and then I had the opportunity to work at the PCP centre run by Fay, to teach and do therapy, then later, PCP and education and finally with David Winter in his psychology department. And over two decades I was developing what I thought of as a ‘constructivist phenomenology’.
Reductive Dechlorination of Tetrachloroethene to Ethene by a Two-Component Enzyme Pathway

ABSTRACT Two membrane-bound, reductive dehalogenases that constitute a novel pathway for complete dechlorination of tetrachloroethene (perchloroethylene [PCE]) to ethene were partially purified from an anaerobic microbial enrichment culture containing Dehalococcoides ethenogenes 195. When titanium(III) citrate and methyl viologen were used as reductants, PCE-reductive dehalogenase (PCE-RDase) (51 kDa) dechlorinated PCE to trichloroethene (TCE) at a rate of 20 μmol/min/mg of protein. TCE-reductive dehalogenase (TCE-RDase) (61 kDa) dechlorinated TCE to ethene. TCE,cis-1,2-dichloroethene, and 1,1-dichloroethene were dechlorinated at similar rates, 8 to 12 μmol/min/mg of protein. Vinyl chloride and trans-1,2-dichloroethene were degraded at rates which were approximately 2 orders of magnitude lower. The light-reversible inhibition of TCE-RDase by iodopropane and the light-reversible inhibition of PCE-RDase by iodoethane suggest that both of these dehalogenases contain Co(I) corrinoid cofactors. Isolation and characterization of these novel bacterial enzymes provided further insight into the catalytic mechanisms of biological reductive dehalogenation.