Miracle-dz/UniFAR-FTUs huggingface dataset:
IPSPA: CONSTRUÇÃO DE UM ÍNDICE DE POTENCIALIDADE SOCIOECONÔMICO, PRODUTIVO E AMBIENTAL PESQUEIRO UTILIZANDO O MÉTODO AHP

A importância da atividade pesqueira abrange questoes sociais, economicas, produtivas e naturais para as comunidades que a praticam, gera alimento, renda, e e considerada a principal fonte de recursos para as familias de tais comunidades. Entao, com o intuito de conseguir mensurar o potencial desenvolvimento dos locais que exercem essa atividade, o presente estudo objetivou apresentar a construcao de um indice de potencialidade, utilizando o Metodo AHP, a fim de hierarquizar localidades quanto ao seu potencial desenvolvimento perante a atividade pesqueira, quando comparadas entre si. Considerando que a aplicacao dessa metodologia pode vir a contribuir com o desempenho dos locais a serem estudados, optou-se pelo AHP pelo fato de ser um metodo muito utilizado para integracao e analise de dados, que vem tornar a possivel identificacao, com maior agilidade e confianca, os pontos criticos que sao expostos como vulnerabilidades do setor. Dessa forma, o objetivo foi alcancado, visto que testes foram realizados para comprovar a viabilidade da metodologia, e o passo a passo descrito permite que a mesma seja utilizada de forma clara.
Role of electrochemotherapy in the treatment of metastatic melanoma and other metastatic and primary skin tumors

Electroporation is a novel therapeutic modality that uses pulsed electrical currents to enhance the uptake of drugs, vaccines and genes into cells, and has been used for over 20 years. Electroporation therapy using cytotoxic drugs is called electrochemotherapy. Electrochemotherapy has been studied in vitro, in vivo and in clinical trials. It is potentially useful for treating patients with metastatic tumors, such as melanoma, and even select primary tumors, such as head and neck squamous cell carcinomas and basal cell carcinoma. Various chemotherapeutic agents have been tested with electroporation therapy, but bleomycin and cisplatin are the two most widely used. The biological basis of electroporation therapy is outlined in this review and basic science studies and the limited clinical studies that have involved electrochemotherapy are reviewed. Particular focus is placed on trials involving melanoma, head and neck cancers and other primary and metastatic skin cancers.
A Methodology for Designing and Evaluating Cloud Scheduling Strategies in Distributed Videoconferencing Systems

Over the last few years, videoconferencing systems have experienced several changes that enable videoconferencing applications in personal devices to a high number of users. To efficiently attend this high and variable demand, deploying distributed videoconferencing servers in cloud-based infrastructures is highly recommended. However, videoconferencing systems have particular characteristics that impede the application of regular resource scheduling solutions used in other kinds of distributed environments. In this paper, we propose a methodology to design and evaluate scheduling strategies adapted to the necessities of each specific scenario. It involves using a new metric to estimate the resource consumption of each connection and provides a set of coefficients to evaluate the efficiency of the strategy. We test the methodology in a real setup and compare the behavior and performance of three scheduling algorithms. The conclusion is that the proposed methodology allows us to configure decision policies adapted to the requirements and necessities of a range of use cases. Thereby, we achieve a more efficient way of using cloud resources, improving the service performance and saving costs.
Arquitectura Multihilos Para Motores 3D

Los microprocesadores de multiples cores ya estan llegando a la masas y dejaron de ser algo exclusivos de los servidores y las supercomputadoras. La mayoria de las computadoras personales y consolas de video juegos usan microprocesadores con multiples cores que permiten ejecutar de forma paralela varios hilos de ejecucion en hardware. Por otra parte la velocidad de cada core se ha estabilizado y por lo tanto no es posible mejorar la performance de ejecucion de una aplicacion que se ejecuta en un solo hilo de ejecucion simplemente agregando mas hardware. Pero crear una arquitectura para aplicaciones interactivas en 3D que usen este hardware nuevo es un reto por la necesidad de interaccion entre los diferentes subsistemas. En este articulo se muestra la arquitectura que se creo para el Chromaticity Engine, un motor 3D que fue pensado para aplicaciones interactivas. El objetivo final del articulo es mostrar los diferentes inconvenientes al crear un motor 3D multihilo para aplicaciones interactivas y como se solucionaron esos inconvenientes en el Chromaticity Engine.
Hedging and Value at Risk: A Semi-Parametric Approach

The non‐normality of financial asset returns has important implications for hedging. In particular, in contrast with the unambiguous effect that minimum‐variance hedging has on the standard deviation, it can actually increase the negative skewness and kurtosis of hedge portfolio returns. Thus, the reduction in Value at Risk (VaR) and Conditional Value at Risk (CVaR) that minimum‐variance hedging generates can be significantly lower than the reduction in standard deviation. In this study, we provide a new, semi‐parametric method of estimating minimum‐VaR and minimum‐CVaR hedge ratios based on the Cornish‐Fisher expansion of the quantile of the hedged portfolio return distribution. Using spot and futures returns for the FTSE 100, FTSE 250, and FTSE Small Cap equity indices, the Euro/US Dollar exchange rate, and Brent crude oil, we find that the semiparametric approach is superior to the standard minimum‐variance approach, and to the nonparametric approach of Harris and Shen (2006). In particular, it provides a greater reduction in both negative skewness and excess kurtosis, and consequently generates hedge portfolios that in most cases have lower VaR and CVaR. © 2009 Wiley Periodicals, Inc. Jrl Fut Mark 30:780–794, 2010
Cytologic features of papillary serous adenocarcinoma of the uterine cervix

The cytologic features of papillary serous carcinoma of the cervix (PSCC) have not been described in detail previously. In this study the cytologic features of primary, pure PSCC are described and correlated with the histology. Comparison is made with papillary serous ovarian carcinoma metastatic to the cervix.
β-Fructofuranosidase Genes of the Silkworm, Bombyx mori

Mulberry latex contains extremely high concentrations of alkaloidal sugar mimic glycosidase inhibitors, such as 1,4-dideoxy-1,4-imino-d-arabinitol (d-AB1) and 1-deoxynojirimycin (DNJ). Although these compounds do not harm the silkworm, Bombyx mori, a mulberry specialist, they are highly toxic to insects that do not normally feed on mulberry leaves. d-AB1 and DNJ are strong inhibitors of α-glucosidases (EC 3.2.1.20); however, they do not affect the activity ofβ-fructofuranosidases (EC 3.2.1.26). Althoughα-glucosidase genes are found in a wide range of organisms, β-fructofuranosidase genes have not been identified in any animals so far. In this study, we report the identification and characterization of β-fructofuranosidase genes (BmSuc1 and BmSuc2) from B. mori. The BmSuc1 gene was highly expressed in the midgut and silk gland, whereas the expression of BmSuc2 gene was not detected. BmSuc1 encodes a functional β-fructofuranosidase, whose enzymatic activity was not inhibited by DNJ or d-AB1. We also showed that BmSUC1 protein localized within the midgut goblet cell cavities. Collectively, our data clearly demonstrated that BmSuc1 serves as a sugar-digesting enzyme in the silkworm physiology. This anomalous presence of the β-fructofuranosidase gene in the B. mori genome may partly explain why the silkworm can circumvent the mulberry's defense system.
Subcutaneous, Blastic Natural Killer (NK), NK/T-cell, and Other Cytotoxic Lymphomas of the Skin: A Morphologic, Immunophenotypic, and Molecular Study of 50 Patients

A new group of subcutaneous, natural killer (NK), NK/T-cell, and other cytotoxic T-cell lymphomas of the skin has been recently described, and some have been included as distinct clinicopathologic entities in the classification of hematologic malignancies recently proposed by the World Health Organization. In the European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas, they would be classified either as CD30- large T-cell lymphoma, small/medium pleomorphic T-cell lymphoma, or subcutaneous T-cell lymphoma. Precise clinicopathologic and prognostic features of all of them have not yet been well characterized. We studied retrospectively 81 biopsies from 50 patients with subcutaneous, blastic natural killer (NK), NK/T-cell, or other non–mycosis fungoides cytotoxic T-cell lymphomas of the skin. Clinical, morphologic, phenotypical, and genetic features and data on Epstein-Barr virus association allowed us to classify our cases according to the following 7 categories: a) subcutaneous “panniculitis-like” T-cell lymphoma (SPTCL): 10 cases (estimated 5-year survival: 80%); b) blastic NK-cell lymphoma: 12 cases (estimated 5-year survival: 0%); c) nasal-type extranodal NK/T-cell lymphoma: 5 patients (estimated 5-year survival: 0%); d) epidermotropic CD8+ T-cell lymphoma: 5 cases (estimated 5-year survival: 0%); e) cutaneous γ/δ T-cell lymphoma: 8 cases (estimated 5-year survival: 0%); f) cutaneous α/β pleomorphic T-cell lymphoma: 8 cases (estimated 5-year survival: 0%); and g) cutaneous medium/large pleomorphic T-cell lymphoma, not otherwise specified: 2 cases. Our study shows that these cutaneous lymphomas can be classified according to precise diagnostic categories. With the exception of SPTCL, analysis of follow-up data from our patients showed that these groups of lymphomas are characterized by an aggressive course, regardless of the diagnostic category.
T cell receptor usage of virus‐specific CD8 cells and recognition of viral mutations during acute and persistent hepatitis B virus infection

T cells specific for a single viral epitope, but using different T cell receptors, should have flexibility in their epitope recognition to protect the infected host against the emergence of viral escape mutants. Therefore, polyclonality of the hepatitis B virus (HBV)‐specific cytotoxic T lymphocyte response has been hypothesized to be a major determinant in the control of infection. We analyzed the Vβ chain composition of the core 18‐27‐specific CD8 cells in acute and persistently HBV‐infected patients using HLA‐A2 tetrameric complexes and a panel of Vβ antibodies. Different T cell receptors were utilized by core 18‐27‐specific CD8 cells both in patients with acute and chronic infection. The functional ability of these epitope‐specific T cells to respond to potential viral mutations was then tested. The polyclonal HBV‐specific CD8 response present in patients with acute hepatitis displayed a limited efficiency to recognize mutations introduced within the epitope. The ability of core 18‐27‐specific CD8 to tolerate epitope mutations was found only during persistent HBV infection. The data suggest that although a clonally heterogeneous CD8 response can be largely inhibited by the occurrence of single epitope mutations in primary HBV infection, preferential selection of T cells able to counteract the emergence of viral mutations can occur during persistent infection.
Review of Percutaneous Kyphoplasty in China

Study Design. Review article. Objective. The article mainly reviewed the development and current situation of percutaneous kyphoplasty (PKP) in China, aiming to introduce native efforts and progress for PKP procedure on the exploring road. Summary of Background Data. Since PKP was first reported in China in 2002, Chinese orthopedic researchers have performed lots of clinical applications and studies on the treatment of osteoporotic vertebral compression fracture, spinal metastatic tumor, hemangioma, myeloma, vertebral nonunion, and so on. Methods. We reviewed the papers on PKP published by native researchers in English and Chinese via Pubmed, EMBASE, the Scopus database, and a series of Chinese databases including Wanfang Data, China National Knowledge Infrastructure (CNKI), and the China Science and Technology Journal Database. The large sample capacity researches, convictive systematic analysis, and overviews were mainly elected as convictive evidence to describe the overall situation of clinical outcomes, complications, and the various technical aspects used to improve conventional surgical management and clinical applications of PKP in China. Results. Until October 2015, 211 articles in English and 2352 studies in Chinese about PKP were reported by 1443 Chinese institutions from 22 provinces around China. More than 50976 patients reported through published articles have received the treatment of PKP. With the technique gradually improved, including puncture, bone cement infusion, vertebral expander instruments, diagnosis, and treatment of special type of vertebral fractures, PKP is performed with the better efficacy and less complication. Conclusion. With the progression of minimally invasive spinal surgery around the world, PKP in China has been performed with a trend towards a rapid, safe, and effective treatment. Digital, real-time and artificial intelligence are the directions of future development of PKP. Level of Evidence: 4
THE CHALLENGES OF ACCURATE MEASUREMENT OF HEALTH‐RELATED QUALITY OF LIFE IN FRAIL ELDERLY PEOPLE AND DEMENTIA

presented as a poster at the British Geriatric Society Spring Meeting, Glasgow, United Kingdom, April 2008. We thank Professor Gordon Wilcock and Dr. Gavin Pinniger for help with study design, Dr. Judy Haworth for supporting subject recruitment, and Dr. Hamish Roots for help with data analysis Conflict of Interest: The editor in chief has reviewed the conflict of interest checklist provided by the authors and has determined that the authors have no financial or any other kind of personal conflicts with this letter. Funding provided by the British Geriatrics Society, BRACE Appeal Alzheimer’s Research Charity. Author Contribution: VL, KR, and TA: study concept and design. VL: acquisition and analysis of data. VL, KR, and TA: interpretation of data and preparation of manuscript. Sponsor’s Role: None.
Acetabular dysplasia and familial joint laxity: two etiological factors in congenital dislocation of the hip. A review of 589 patients and their families.

1. A survey of genetic and other etiological factors has been carried out in 589 index patients with congenital dislocation of the hip and their families, with special investigation of acetabular dysplasia, familial joint laxity and a comparison of neonatal and late-diagnosis cases. 2. It is believed that there are two etiological groups with congenital dislocation of the hip, i) a group with acetabular dysplasia which is inherited as a multiple gene system and is responsible for a high proportion of cases diagnosed late, and ii) a group with joint laxity which is responsible for a high proportion of neonatal cases. 3. Evidence is presented to show that acetabular dysplasia is a separate heritable system in some families. 4. Other findings relating to the genetic aspects of the survey are summarised.
Schizophrénie résistante, réflexion autour d'un cas résistant à la clozapine

La schizophrenie resistante est definie comme une reponse inadequate a deux traitements antipsychotiques differents pour une duree et une posologie suffisante. La clozapine est le seul traitement medicamenteux actuellement autorise pour les patients atteints de schizophrenie resistante, il est associe a un faible taux de readmission a l’hopital par rapport a d’autres antipsychotiques. Toutefois, un long retard d’initiation dans la pratique clinique courante a ete rapporte. Ce travail presente un rapport de cas illustrant le parcours psychiatrique d’un patient souffrant de schizophrenie resistante. A travers une revue de la litterature, nous essayons de mieux definir les contours de cette entite clinique qui ne dispose pas de definition consensuelle. Si plusieurs arguments suggerent que la clozapine est efficace pour les patients souffrant de schizophrenie resistante, le retard de son instauration represente un veritable facteur limitant son efficacite. Par consequent, sa prescription dans les meilleurs delais, permet de tirer le maximum de benefices. La clozapine ne doit pas etre presentee comme le traitement de la derniere chance mais un remede de premiere intention chez les patients souffrant de schizophrenie resistante. En cas de reponse insuffisante, la psychoeducation et l’association d’autres molecules representent des complements necessaires a cette molecule.
Fusion de données, estimation de la posture et navigation à l'estime : Application au Bio-logging

Le cadre d'etude est la reconstitution de la posture (attitude), des accelerations propres et des deplacements chez l'animal (Bio-logging). La representation de l'attitude choisie est le quaternion et les mesures accessibles sont issues d'une triade de capteurs comportant un accelerometre, un magnetometre et un gyrometre. Trois approches estimant le quaternion a partir de ces donnees ont ete proposees. La premiere est sous la forme d'un observateur non lineaire additif et utilise la technique d'addition de quaternion pour la mise a jour des estimes. La deuxieme et la troisieme approche sont representees, respectivement, par un observateur a modes glissants et un filtre complementaire. La technique de mise a jour utilisee repose sur la multiplication de quaternion. Les resultats d'estimation a l'issue des simulations theoriques et experimentales sont satisfaisants et sont promoteurs pour calculer les accelerations propres et les deplacements. Nous avons presente a la fin une approche de navigation a l'estime permettant de remonter a la position d'un mobile a locomotion pedestre avec les memes mesures. Les resultats experimentaux obtenus sont prometteurs au Bio-logging.
Nutritional status in liver cirrhosis.

The metabolism of many nutritional elements (carbohydrate, protein, fat, vitamins, and minerals) is gradually disturbed with progressive chronic liver diseases. In particular, protein‐energy malnutrition (PEM) is known as the most characteristic manifestation of liver cirrhosis (LC) and is closely related to its prognosis. Recently, while sarcopenia (loss of muscle mass and strength or physical performance) has been discussed as an indepen‐ dent factor associated with prognosis in patients with LC, obesity and insulin resistance in patients with LC also contribute to carcinogenesis in LC. Deficiencies of zinc and car ‐ nitine are involved in the malnutrition in LC and are associated with hyperammonemia, which is related to the pathogenesis of hepatic encephalopathy. Because the nutritional and metabolic disturbances in LC are fundamentally influenced by many factors, such as the severity of liver damage, the existence of portal‐systemic shunting, and inflam ‐ mation, proper nutritional assessment is necessary for the nutritional management of patients with LC.
Effects of heat conditioning at d 16 to 18 of incubation or during early broiler rearing on embryo physiology, posthatch growth performance and heat tolerance

It is well known that cells preincubated at sublethal high temperatures can survive longer when exposed to lethal temperatures. In addition heat shock response, regulated to some extent by heat shock proteins, is necessary for the acquisition of induced thermotolerance in chickens (YAHAV et al., 1997). According to YAHAV and MCMURTRY, (2001), the main idea behind the thermal conditioning process is to incorporate thermoregulatory threshold response changes that enable chickens to cope, within certain limits, with acute exposure to unexpected heat spells. Since the technique of temperature conditioning takes advantage of the immaturity of the temperature regulation mechanism in the young chick (DUNNINGTON and SIEGEL, 1984), it is hypothesised that a potentially better thermotolerance could be induced in the developing mechanism of thermoregulation by early conditioning during incubation or through a combination of this pre-hatch conditioning with early post-hatch conditioning. YAHAV and HURWITZ, (1996) reported that thermal conditioning at an early age post-hatch has a negative effect on early performance followed by an accelerated growth leading to regular or higher body weight at slaughter age. The combination of short-term exposure to heat during the first week and feed restriction during the second week resulted in slow growth rate followed by a catch up growth at the end of the second week (YAHAV and PLAVNIK, 1999). ARJONA et al., (1990) reported that broiler cockerels conditioned to neonatal heat (35–37.8°C for 24 hr) at 5 days of age had significantly lower mortality when exposed afterwards to elevated temperatures (35–37.8°C) at 43 days of age. Reports of different studies have shown that epigenetic thermal conditioning can be applied at different periods during the 11th to the 18th d of incubation (IQBAL et al.,
A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses.

In vitro, IL-10 inhibits T cell proliferation and LPS-induced monocyte production of IL-1, TNF-alpha, IL-6, and IL-8. We studied the safety and immunomodulatory effects of IL-10 administration in humans. Seventeen healthy volunteers received a single i.v. bolus injection of either human IL-10 (1, 10, or 25 micrograms/kg) or placebo. Routine safety parameters, lymphocyte phenotypes, T cell proliferative responses, and stimulus-induced cytokine production were assessed before and 3, 6, 24, and 48 h after injection. There were no adverse symptoms or signs after IL-10 administration. A transient neutrophilia and monocytosis that peaked at 6 h (45-160% above base line) was observed. However, lymphocyte counts fell by 25% 3 and 6 h after the injection (p < 0.01). In particular, lymphocytes expressing the T cell surface markers CD2, CD3, CD4, CD7, and CD8 were significantly decreased. Mitogen-induced T cell proliferation was suppressed by up to 50% (p < 0.01) in the two higher dose groups. Significant dose-dependent inhibition (65-95%) of TNF-alpha and IL-1 beta production from whole blood stimulated ex vivo with endotoxin occurred after each dose of IL-10. In contrast, there was no reduction in the production of their respective antagonists, TNF soluble receptor p55 or IL-1 receptor antagonist. We conclude that a single intravenous injection of IL-10 is safe in humans, has inhibitory effects on T cells, and suppresses production of the pro-inflammatory cytokines TNF-alpha and IL-1 beta.
The effect of soaking and cooking on the oxalate content of taro leaves

Pacific Island people commonly eat taro (Colocasia esculenta var. Schott) as a staple food in their home islands and also like to consume this familiar food when living in New Zealand. Some of these foods are imported from the islands and some attempts are, currently, being made to grow these crops in New Zealand. The taro leaves in this experiment were grown in a greenhouse in the North Island of New Zealand. The soluble oxalate content of the raw leaves was 236.10 mg oxalate/100 g wet matter (WM). Soaking the raw leaves in water for 30 min marginally reduces the soluble oxalate content by leaching into the tap water. Soaking for 18 h results in a 26% reduction in the soluble oxalate content of the raw leaves. During the soaking treatments the insoluble oxalate (calcium oxalate) content of the leaves remained constant (mean 171.64 mg oxalate/100 g WM). Boiling the taro leaves resulted in a 36% loss of soluble oxalates, while the soluble oxalate content of baked tissue was very similar to the raw tissue. The mean insoluble oxalate content of the raw, boiled and baked tissue was 226.28 mg oxalate/100 g WM. Overall, boiling the taro leaves was an effective way of reducing the soluble oxalate content of the cooked tissue.