Miracle-dz/UniFAR-FTUs huggingface dataset:
Fancy a coffee with Friends in ‘Central Perk’?

Fictional brands are brands that exist only in the world of fiction and not the real physical world. Reverse product placement consists of transforming these fictional brands into products and services in the real physical world. This paper posits that consumers, despite having no preexisting experience of fictional brands in the real world, may develop positive attitudes towards fictional brands; hence the fundamental managerial question is to ascertain whether these positive attitudes can drive purchase intention to justify the investment into a real product or service based on the fictional brand. Using two fictional service brands, ‘MacLaren’s Pub’ and ‘Central Perk’, featured respectively in How I Met Your Mother and Friends, this study confirms the existence of proto brands, and shows that attitudes towards a fictional brand are driven by perceived service quality, identification with the brand and attitudes towards the television programme. The study goes on to provide evidence that attitudes towards the fictional brand can influence purchase intention of a future defictionalised brand in the real world. The paper contributes to product placement and branding literature in a new emerging area.
DEET: A Review and Update of Safety and Risk in the General Population

Abstract The emergence of West Nile Virus (WNV) in North America has resulted in increased public awareness and utilization of insect repellents containing N,N‐diethyl‐m‐toluamide (DEET) in the prevention of mosquito‐borne disease. Regulatory reassessments in North American countries have recently been completed for insect repellents containing DEET as active ingredient, resulting in labeling changes intended to minimize unnecessary exposure to special populations, including children. This article describes those changes, and summarizes more recent data relating to the pharmacokinetics, toxicology, and epidemiology of adverse effects associated with DEET in humans.
Multi-User Analog Network Coding with Spread Spectrum

In this paper, we propose a physical layer network coding technique combined with asynchronous code division multiple access (CDMA). We consider a scenario where there are multiple pair of nodes with a single relay, and each pair of nodes exchange information asynchronously. With the assumption of asynchronous transmission, there is a trade-off between the number of nodes and the inter-user interference because the spreading codes are not orthogonal to each other. The BER and the throughput of the system are analyzed, and simulations are performed to verify the results. It is shown that physical layer (analog) network coding improves throughput compared to the conventional routing protocol with large Eb/N0, low number of users, and large spreading factor.
Factors Associated With Treatment Failure of Helicobacter pylori Infection in a Developing Country

Background Although no regimen can eradicate Helicobacter pylori in 100% of patients, factors that may affect the eradication rates have been poorly studied. Goal To evaluate factors associated with H. pylori treatment failure. Study One hundred patients were treated with pantoprazole plus clarithromycin and furazolidone for H. pylori eradication. Clarithromycin and furazolidone resistance was evaluated by the agar dilution method. Point mutations in 23S rRNA genes related to clarithromycin resistance were investigated by polymerase chain reaction and restriction length fragment polymorphism and cag A by polymerase chain reaction. The data were analyzed by logistic regression. Results H. pylori eradication occurred in 85 of 97 patients who completed the treatment (87.6%; 95% CI = 79.0–93.1). All H. pylori strains were susceptible to furazolidone, and nine were resistant to clarithromycin (A2142G or A2143G mutation was detected in all of them). The treatment failure was significant and independently associated with clarithromycin resistance (OR = 7.79; 95% CI = 1.73–35.01), cag A-negative status (OR = 4.81; 95% CI = 1.14–20.14), and male gender (OR = 4.20; 95% CI = 1.01–17.78), but not with the type of disease, mean age, smoking, alcohol consumption, and the degree of the antral and oxyntic gastritis. Conclusion Resistance to clarithromycin, cag A-negative status, and gender were predictive factors of H. pylori eradication failure.
Analysis of DNA Repair–Related Genes in Breast Cancer Reveals CUL4A Ubiquitin Ligase as a Novel Biomarker of Trabectedin Response

Trabectedin is more active in nucleotide excision repair (NER)-efficient and homologous recombination repair (HRR)-deficient cells. As up to 25% of sporadic breast tumors present somatic inactivation of the HRR pathway (BRCAness phenotype), we sought to characterize trabectedin effect in BRCA1-proficient and BRCA1-null breast cancer cell lines. We evaluated whether HRR and NER gene expression correlates with trabectedin sensitivity and explored the response predictive value of the CUL4A ubiquitin ligase, which ubiquitinates NER pathway members. We characterized trabectedin cytotoxicity, cell-cycle effects, and BRCA1, BRCA2, XRCC3, XPG, ERCC1, and CUL4A expression in 10 breast cancer cell lines. Gene expression and trabectedin sensitivity association were determined in cell lines. Survival assays after trabectedin treatment were conducted in CUL4A-silenced BRCA1-proficient and -deficient cells. Because of limited phase II clinical trials evaluating trabectedin efficacy in patients with breast cancer, we assessed CUL4A immunohistochemical staining in a retrospective series of 118 sarcomas from trabectedin-treated patients to validate in vivo our in vitro observations. In cell lines, greater trabectedin sensitivity was associated with higher CUL4A expression and lower BRCA1/ERCC5, BRCA1/CUL4A, and XRCC3/CUL4A expression ratios. In agreement, BRCA1-deficient CUL4A-knockdown cells presented higher cell survival after trabectedin exposure than did scramble control cells. Lack of effect in BRCA1-proficient cells suggests that HRR impairment is key in CUL4A-mediated trabectedin sensitivity. High CUL4A expression in nontranslocation-related patients with sarcoma predicted improved progression-free survival [PFS; HR, 0.37; 95% confidence interval (CI), 0.20–0.68, P = 0.001] and overall survival (OS; HR, 0.44; 95% CI, 0.21–0.93, P = 0.026). Our observations support the notion of greater trabectedin activity in tumors exhibiting BRCAness and reveal CUL4A as a potential biomarker for definition of trabectedin target patients. Mol Cancer Ther; 12(4); 530–41. ©2013 AACR.
An object‐oriented bulk synchronous parallel library for multicore programming

We show that the bulk synchronous parallel (BSP) model, originally designed for distributed‐memory systems, is also applicable for shared‐memory multicore systems and, furthermore, that BSP libraries are useful in scientific computing on these systems. A proof‐of‐concept MulticoreBSP library has been implemented in Java, and is used to show that BSP algorithms can attain proper speedups on multicore architectures. This library is based on the BSPlib implementation, adapted to an object‐oriented setting. In comparison, the number of function primitives is reduced, while the overall design simplicity is improved. We detail applying the BSP model and library on the sparse matrix–vector (SpMV) multiplication problem, and show by performing numerical experiments that the resulting BSP SpMV algorithm attains speedups, in one case reaching a speedup of 3.5 for 4 threads. Whereas not described in detail in this paper, algorithms for the fast Fourier transform and the dense LU decomposition are also investigated; in one case, attaining superlinear speedups of 5 for 4 threads. The predictability of BSP algorithms in the case of the SpMV is also investigated. Copyright © 2011 John Wiley & Sons, Ltd.
A Comparative Analysis of Privacy Preserving Techniques in Online Social Networks

The world became a global village due to the great revolution in communication and network fields. The internet eases the communication process all over the world. The social network services, for example; Facebook, that occurred recently are considered one of the most essential and common outcomes due to this revolution. People from different ages, views, cultures, languages, religions, education levels, etc. from all over the world can easily communicate through the social networks. Furthermore; people can share their news and personal information with each other. It can be also noticed that the social network are extensively used, so the privacy issues within it is essentially to be considered. This privacy will prevent any illegal accessing for the user personal information which in turns will increase the users’ conviction to use these networks during their daily life and encourage the other people who have never use the services that are available for using by social networks. This paper analyses several techniques which provides the privacy for Online Social Networks including Reclaim, Safebook, K-Automorphism, Vis-a-vis and SPKA. These techniques are investigated and clarified in terms of their methods in addition to the advantages and drawbacks.
Multidecadal and multicentennial variability of the meridional overturning circulation

The variability of the meridional overturning circulation (MOC) simulated in a multimillenial control integration of the Kiel Climate Model (KCM) displays enhanced variability relative to the red background at decadal and centennial timescales. The multidecadal variability is the model's version of the Atlantic Multidecadal Variability (AMV), often referred to as Atlantic Multidecadal Oscillation (AMO). While multidecadal variability originates in the North Atlantic, multicentennial variability is driven in the Southern Ocean. Both multidecadal and multicentennial variability are associated with considerable changes in sea ice extent. This may be important to understand the different evolution of sea ice cover in the Northern and Southern Hemisphere during the most recent decades, with a strong decline observed in the North and almost no trend in the South.
Ergonomic factors: the clarity of food labels.

The Government has recently made public its response to the Food Advisory Committee′s review of food labelling practices. Among the accepted recommendations, the presentation of labelling information is recognized to be of key importance. Presents a review of the ergonomic factors which affect the clarity of pack information and discusses the relevance of these findings for the design of effective food labelling.
The action of peptides on the adrenal medulla. Release of adrenaline by bradykinin and angiotensin

The present experiments show that bradykinin and angiotensin are potent releasers of the medullary hormones, probably mainly adrenaline, from the suprarenal glands. Angiotensin is more potent in this respect than any other known substance. These findings were the outcome of a chance observation made when assaying bradykinin by its depressor action on the arterial blood pressure of the cat. On trying to render the assay more sensitive by removing the abdominal viscera and injecting the bradykinin through the central stump of the coeliac artery at its origin from the abdominal aorta above the suprarenals, bradykinin caused a fall, followed after 20-30 sec by a pronounced rise, in arterial blood pressure associated with acceleration of heart rate. The pressor effect and the cardio-acceleration were abolished after removal of the suprarenal glands and were therefore due to release of their medullary hormones. Such an action of bradykinin has been described in rabbits and rats (Lecomte, Troquet & Dresse, 1961), but no quantitative data of the release have been reported. We therefore investigated quantitatively this adrenaline-releasing effect of bradykinin and related kinins. On extending the experiments to angiotensin an extreme sensitivity of the suprarenal medulla to this peptide was revealed. Three other peptides, vasopressin, oxytocin and substance P, did not have this property. Examined under similar conditions they did not cause a detectable release of adrenaline from the suprarenals.
What is the role of genetic testing in diagnosis of haemochromatosis?

What is genetic haemochromatosis? Haemochromatosis is the clinical condition of iron overload. Genetic haemochromatosis refers to the inheritance of the iron-loading phenotype [previously called idiopathic or human leukocyte antigen (HLA)-linked haemochromatosis]. Genetic haemochromatosis is caused by increased iron absorption from food. This leads to iron accumulation in the tissues because the body has no means of getting rid of excess iron. In advanced disease, iron accumulation may cause diabetes, cirrhosis and skin pigmentation. The condition is inherited in autosomal recessive fashion and the gene lies close to the HLA-A region on chromosome 6. The diagnosis is made by biochemical testing, with con®rmation by liver biopsy. It is a treatable condition. The excess iron can be removed by phlebotomy ± weekly venesection of 500 mL of blood. This may take up to 2 years. The mean age of diagnosis for 251 patients studied between 1947 and 1991 was 46 11 years [mean standard deviation (SD)]. Bothwell and Macphail have made a detailed review of both the clinical and the genetic aspects of haemochromatosis. This present review is concerned only with HLAlinked iron overload and not with `African’ iron overload or the much rarer `neonatal’ haemochromatosis and `juvenile’ haemochromatosis.
Increasing longevity and medicare expenditures

Official Medicare projections forecast that the elderly population will be less healthy and more costly over the next century. This prediction stems from the use of age as an indicator of health status: increases in longevity are assumed to increase demand for health care as individuals survive to older and higher-use ages. In this paper I suggest an alternative approach, in which time until death replaces age as the demographic indicator of health status. Increases in longevity are assumed to postpone the higher Medicare use and costs associated with the final decade of life. I contrast the two approaches, using mortality forecasts consistent with recent projections from the U.S. Census Bureau and the Social Security Administration. The time-until-death method yields significantly lower-cost forecasts. The hypothetical cost savings from improved health are small, however, relative to the size of the Medicare solvency problem caused by population aging.
New Banking Technology in Hong Kong

The introduction of a financial service – the easy pay system – in Hong Kong is the subject of study. It is a form of electronic fund transfer at point of sale and is considered as a continuous innovation in the evolution of the electronic fund transfer systems. Irrespective of the theoretical benefits – safe, convenient and a sound approach to fund management – associated with the service, the adoption rate is not encouraging. The peculiarities of the marketing issues associated with the life cycle of financial service innovations are discussed. It is contended that the successful introduction of services in the earlier stages of the life cycle may be both an asset and a liability to later innovations. As such, a continuous educational programme is deemed necessary to capitalise on the positive effects carried over from earlier phases of the life cycle.
Upgrading of Industrial Structure in the Pearl River Delta Region

While the transformation of the industrial structure involves economic efficiency,industrial upgrading is concerned with evolution of the industrial structure from a lower level to a higher level.The routes towards industrial upgrading are mainly either within the industry or inter-industry,but not simply transferring from one industry to another.At present,there are so many misunderstandings about this topic such as all-is-a-slogan view towards industrial transformation and upgrading,the theory of technology vest,the theory of the high-tech route,the view of hopelessness toward traditional industries,and the theory of instant success.All these views do harm to practical work.The present article urges that in promoting industrial transformation and upgrading,the government should adopt new policies to cater to the demand of the businesses,to help form a group of powerful industrial clusters with strengths in innovation and influence,and to make the Pearl River delta region the best platform for commodity production and distribution.
Third party logistics : a literature review and research agenda

Purpose – To provide a taxonomy of third party logistics (3PL) research and, based on that, to develop a research agenda for this field of study.Design/methodology/approach – The proposed 3PL research classification framework is based on a comprehensive literature review, which concentrates on peer‐reviewed journal papers published within the period 1990‐2005. A total of 114 academic sources have been retrieved and analysed in terms of research purpose and nature, method employed, theoretical approach and level of analysis.Findings – The review reveals that 3PL research is empirical‐descriptive in nature and that it generally lacks a theoretical foundation. Survey research is the dominant method employed, reflecting the positivist research tradition within logistics. It identifies certain knowledge gaps and develops five propositions for future research. It suggests that focus should be directed towards more normative, theory‐driven and qualitative method‐based studies. It also argues that further empiric.
Studies of the immunology of the newborn infant. II. Interference with active immunization by passive transplacental circulating antibody.

Forty infants from 1 week to 6 months of age who had no circulating antitoxin were immunized with one injection of a high titer diphtheria toxoid on alum and their antitoxin responses were followed at regular intervals up to six months afterwards. The ability to form antitoxin improved significantly during the first two months of life. No significant difference could be demonstrated between the response of infants 2 to 4 months of age and that of infants 6 months of age. (In the statistical tests, the 5% level was adopted as indicating significance.) Twenty-seven of these infants were immunized at the same time in the opposite arm with a single dose of tetanus toxoid on alum. The response to tetanus immunization was faster and better in infants from 2 to 6 months of age than in infants 1 month of age and younger. The response to the tetanus toxoid preparation was faster and better than the response to the diphtheria toxoid preparation. The following conclusions are drawn: A. The infant can form antibodies from birth. B. The ability to form antibodies improves during early life. For diphtheria and tetanus antitoxin, the improvement is rapid during the first two months and then is much slower. C. The advisability of early immunization is related to the potency of the antigen to be used.
Improvement of jojoba shoot multiplication in vitro by ventilation

SummaryThe effect of ventilation during the multiplication stage on the development of propagules from different clones of jojoba [Simmondsia chinensis (Link) Schneider] was investigated. Variation in the response to ventilation was due to genotype, the extent of ventilation, and to the period of exposure (transfer number). With intermediate ventilation treatments, propagules elongated to a greater extent and produced more dry biomass than propagules grown without ventilation. In the highest ventilation treatment, however, growth parameters were negatively affected. More importantly, propagules grown with moderate ventilation produced more plant material suitable for further multiplication and for the elongation stage than those grown in sealed tubes—the vessels used in our original micropropagation system. In five of the seven clones studied, growth and multiplication rate were decreased by the highest ventilation treatment. Propagules from the second and third multiplication transfers into ventilated vessels became more sensitive to high ventilation. Ambient water loss was slower in propagules produced under ventilation, probably due to smaller stomatal apertures. As a result of improved growth and decreased hyperhydricity by ventilation, the micropropagation protocol should be modified to include Magenta boxes equipped with vented lids as the preferred growing vessels.
Earning Quality of Food and Beverage Companies Listed in the Stock Exchange of Thailand: Implication from Discretionary Accruals

This study aims to analyze the earning quality of 24 food and beverage companies listed in the Stock Exchange of Thailand (SET) during 2007-2011 by considering earning management which is calculated as the discretionary accruals based on Kothari et al., (2005). The findings reveal that food and beverage companies obviously have earning management with the average discretionary accrual in absolute term of 5.56 percent of total assets. The findings also reveal that the earning quality of food and beverage companies in average is somewhat higher than that of overall companies in the Stock Exchange of Thailand but lower than that of overall companies in the Market for Alternative Investment (MAI). After considering the earning quality of food and beverage companies as grouped by fundamental characteristics, it was found that the companies
Hypodontia and tooth formation in groups of children with cleft, siblings without cleft, and nonrelated controls.

OBJECTIVE To compare the occurrence of hypodontia, dental age, and asymmetric dental development in children with cleft with their siblings and a nonsibling control group. SUBJECTS The sample consisted of 54 children with cleft (aged 4.2 to 13.1 years), who had at least one sibling available for an orthopantomogram, 63 siblings without cleft (aged 4 to 14.9 years) and 250 controls without cleft (aged between 4 and 14.9 years). METHOD Hypodontia, dental age, and asymmetric dental development were assessed on panoramic radiographs of the children with cleft, the siblings without cleft, and the control children without cleft. RESULTS Both the cleft (p <.001) and the sibling group (p <.05) showed a significantly higher frequency of hypodontia and a significantly higher occurrence (cleft p <.01 and sibling group p <.001) of asymmetric dental development, compared with the control group. Only a small, but insignificant, delay in dental development could be found in the cleft and the sibling group. CONCLUSIONS; The cleft subjects with siblings showed a significantly higher occurrence of hypodontia and asymmetric dental development than the noncleft control group. This may suggest a genetic component for the occurrence of hypodontia and asymmetric dental development.
Exon 11 skipping of SCN10A coding for voltage-gated sodium channels in dorsal root ganglia

The voltage-gated sodium channel NaV1.8 (encoded by SCN10A) is predominantly expressed in dorsal root ganglia (DRG) and plays a critical role in pain perception. We analyzed SCN10A transcripts isolated from human DRGs using deep sequencing and found a novel splice variant lacking exon 11, which codes for 98 amino acids of the domain I/II linker. Quantitative PCR analysis revealed an abundance of this variant of up to 5–10% in human, while no such variants were detected in mouse or rat. Since no obvious functional differences between channels with and without the exon-11 sequence were detected, it is suggested that SCN10A exon 11 skipping in humans is a tolerated event.