Miracle-dz/UniFAR-FTUs huggingface dataset:
Design and Implementation of Retrieval System of Network Learning Resources Based on Semantic Web

The gradual finding of large quantities of low-relevant or even non-relevant information is returned by the traditional keyword-based query. To further improve the efficiency and quality of network learning resources retrieval, this article designs a generic Semantic Web-based e-learning resources retrieval system model and achieves B/S mode of semantic retrieval prototype system, considering the influence of various factors for the similarity and correlation, such as degree of semantic overlap, semantic distance, semantic hierarchy, and property relation. By comparing with the traditional query, the retrieval results showed that the semantic retrieval methods to ensure precision in the case of a higher recall rate.
The Lumenal Domain of the Integral Membrane Protein Phogrin Mediates Targeting to Secretory Granules

Phogrin, a transmembrane glycoprotein of neuroendocrine cells, is localized to dense‐core secretory granules. We have investigated the subcellular targeting of phogrin by analyzing the sorting of a series of deletion mutants to the regulated pathway of secretion in AtT20 cells. The lumenal domain as a soluble protein was efficiently routed to granules, based on a combination of morphological analysis and secretion studies. Sorting was not dependent on a candidate targeting signal consisting of an N‐terminal conserved cysteine‐rich motif. Both the pro‐region and the lumenal domain of mature, post‐translationally processed phogrin independently reached the granule, although the pro‐region was sorted more efficiently. Once within the regulated secretory pathway, all phogrin lumenal domain proteins were stored in functional granules for extended periods of time. Thus, phogrin possesses several domains contributing to its targeting to the secretory granule. Our findings support a model of granule biogenesis where proteins are sorted on the basis of their biochemical properties rather than via signal‐dependent binding to a targeting receptor. Sorting of integral membrane proteins mediated by the lumenal domain may ensure that functionally important transmembrane molecules are included in the forming granule.
Controlling the emission properties of multimode vertical-cavity surface-emitting lasers via polarization- and frequency-selective feedback

Y. Kouomou Chembo,* Shyam K. Mandre, Ingo Fischer, Wolfgang Elsasser, and Pere Colet Institut FEMTO-ST (UMR CNRS 6174), Departement d’Optique P. M. Duffieux, Universite de Franche-Comte, 16 Route du Gray, 25030 Besancon cedex, France Instituto de Fisica Interdisciplinar y Sistemas Complejos IFISC (CSIC-UIB), Campus Universitat de les Illes Balears, E-07122 Palma de Mallorca, Spain Institute of Applied Physics, Darmstadt University of Technology, Schlossgartenstrasse 7, D-64289 Darmstadt, Germany School of Engineering and Physical Sciences and Joint Research Institute of Integrated Systems, Heriot-Watt University, Edinburgh EH14 4AS, United Kingdom Received 16 October 2008; published 21 January 2009
Trust Aware System for Social Networks: A Comprehensive Survey

Social networks are the platform for the users to get connected with other social network users based on their interest and life styles. Existing social networks have millions of users and the data generated by them are huge and it is difﬁcult to differentiate the real users and the fake users. Hence a trust worthy system is recommended for differentiating the real and fake users. Social networking enables users to send friend requests, upload photos and tag their friends and even suggest them the web links based on the interest of the users. The friends recommended, the photos tagged and web links suggested may be a malware or an untrusted activity. Users on social networks are authorised by providing the personal data. This personal raw data is available to all other users online and there is no protection or methods to secure this data from unknown users. Hence to provide a trustworthy system and to enable real users activities a review on different methods to achieve trustworthy social networking systems are examined in this paper.
Procedimiento de actuación para la aplicación de la directiva marco del agua a los lagos artificiales creados por la rehabilitación de las explotaciones mineras a cielo abierto

Las caracteristicas particulares de las grandes explotaciones a cielo abierto de la mineria metalica y de la mineria del carbon, que originan huecos de grandes dimensiones, hacen que la unica opcion, viable, razonable y sostenible de rehabilitacion del espacio directamente afectado por la excavacion sea su inundacion, dando lugar a los llamados "lagos de mina". Esta solucion no esta exenta, en principio, de complicaciones; sin embargo, hay que destacar que actualmente se conocen diferentes metodos y tecnicas de tratamiento para controlar y mejorar la calidad de las aguas de estas masas, lo que hace que la transformacion de los huecos de explotacion en lagos ofrezca la oportunidad de poner en valor el paisaje minero a traves de nuevas opciones de uso sostenible del suelo. El objeto del presente trabajo, que se presenta como tesis doctoral, es demostrar que la formacion de lagos mineros no es solo una solucion ambiental eficaz y optima para la restauracion de las explotaciones a cielo abierto, sino que ademas constituye una solucion a otras problematicas de la ordenacion del territorio, en particular la relativa a la gestion de los recursos hidricos y la planificacion hidrologica, poniendo de manifiesto la importancia del plan de restauracion del espacio afectado por las actividades mineras como instrumento juridico preventivo de gestion sostenible y planificacion del territorio a corto y largo plazo, integrado de manera efectiva en el sistema de planes ambientales que ordenan de manera directa el uso del suelo. En este estudio se ha realizado un examen directo de los aspectos cientificos, tecnologicos, administrativos, juridicos y sociales relacionados con la formacion de lagos mineros para concluir definiendo el marco de actuacion y las bases adecuadas con las que mejorar la creacion sostenible, la regeneracion efectiva y el uso futuro a largo plazo de estas masas de agua artificiales, sujetas a la aplicacion de la Directiva Marco del Agua.
Finding a druggable target for schizophrenia

Schizophrenia is a devastating brain disease that affects ∼1% of the population worldwide and is characterized by a complex array of positive (delusions and hallucinations), negative (apathy and social withdrawal), and cognitive (deficits in attention and working memory) symptoms. Clinical features of schizophrenia frequently arise during late adolescence or early adulthood, which places this disease as the most chronic of the psychotic disorders and as one of the leading causes of disability and premature mortality (1). Increasing evidence suggests that cognitive impairment is at the core of schizophrenia and precedes the manifestation of psychosis (2). Furthermore, no pharmacological treatment is currently available for cognitive deficits, which are among the most debilitating symptoms of the disorder. The identification of novel treatments to ameliorate the cognitive symptoms of schizophrenia thus seems crucial to improve the quality of life in these patients.
Molecular analysis of FVIII gene in severe HA patients of Costa Rica

Summary Haemophilia A (HA) is X-chromosome linked bleeding disorders caused by deficiency of the coagulation factor VIII (FVIII). It is caused by FVIII gene intron 22 inversion (Inv22) in approximately 45% and by intron 1 inversion (Inv1) in 5% of the patients. Both inversions occur as a result of intrachromosomal recombination between homologous regions, in intron 1 or 22 and their extragenic copy located telomeric to the FVIII gene. The aim of this study was to analyze the presence of these mutations in 25 HA Costa Rican families. Patients, methods: We studied 34 HA patients and 110 unrelated obligate members and possible carriers for the presence of Inv22or Inv1. Standard analyses of the factor VIII gene were used incl. Southern blot and long-range polymerase chain reaction for inversion analysis. Results: We found altered Inv22 restriction profiles in 21 patients and 37 carriers. It was found type 1 and type 2 of the inversion of Inv22. During the screening for Inv1 among the HA patient, who were Inv22 negative, we did not found this mutation. Discussion: Our data highlight the importance of the analysis of Inv22 for their association with development of inhibitors in the HA patients and we are continuous searching of Inv1 mutation. This knowledge represents a step for genetic counseling and prevention of the inhibitor development.
Targeted Ablation of the Abcc6 Gene Results in Ectopic Mineralization of Connective Tissues

ABSTRACT Pseudoxanthoma elasticum (PXE), characterized by connective tissue mineralization of the skin, eyes, and cardiovascular system, is caused by mutations in the ABCC6 gene. ABCC6 encodes multidrug resistance-associated protein 6 (MRP6), which is expressed primarily in the liver and kidneys. Mechanisms producing ectopic mineralization as a result of these mutations remain unclear. To elucidate this complex disease, a transgenic mouse was generated by targeted ablation of the mouse Abcc6 gene. Abcc6 null mice were negative for Mrp6 expression in the liver, and complete necropsies revealed profound mineralization of several tissues, including skin, arterial blood vessels, and retina, while heterozygous animals were indistinguishable from the wild-type mice. Particularly striking was the mineralization of vibrissae, as confirmed by von Kossa and alizarin red stains. Electron microscopy revealed mineralization affecting both elastic structures and collagen fibers. Mineralization of vibrissae was noted as early as 5 weeks of age and was progressive with age in Abcc6−/− mice but was not observed in Abcc6 +/− or Abcc6 +/+ mice up to 2 years of age. A total body computerized tomography scan of Abcc6 −/− mice revealed mineralization in skin and subcutaneous tissue as well as in the kidneys. These data demonstrate aberrant mineralization of soft tissues in PXE-affected organs, and, consequently, these mice recapitulate features of this complex disease.
Research Paper: Use of a Personal Digital Assistant for Managing Antibiotic Prescribing for Outpatient Respiratory Tract Infections in Rural Communities

OBJECTIVE To assess the acceptability and usage of a standalone personal digital assistant (PDA)-based clinical decision-support system (CDSS) for the diagnosis and management of acute respiratory tract infections (RTIs) in the outpatient setting. DESIGN Observational study performed as part of a larger randomized trial in six rural communities in Utah and Idaho from January 2002 to March 2004. Ninety-nine primary care providers received a PDA-based CDSS for use at the point-of-care, and were asked to use the tool with at least 200 patients with suspected RTIs. MEASUREMENTS Clinical data were collected electronically from the devices at periodic intervals. Providers also completed an exit questionnaire at the end of the study period. RESULTS Providers logged 14,393 cases using the CDSS, the majority of which (n=7624; 53%) were from family practitioners. Overall adherence with CDSS recommendations for the five most common diagnoses (pharyngitis, otitis media, sinusitis, bronchitis, and upper respiratory tract infection) was 82%. When antibiotics were prescribed (53% of cases), adherence with the CDSS-recommended antibiotic was high (76%). By logistic regression analysis, the odds of adherence with CDSS recommendations increased significantly with each ten cases completed (P=0.001). Questionnaire respondents believed the CDSS was easy to use, and most (44/65; 68%) did not believe it increased their encounter time with patients, regardless of prior experience with PDAs. CONCLUSION A standalone PDA-based CDSS for acute RTIs used at the point-of-care can encourage better outpatient antimicrobial prescribing practices and easily gather a rich set of clinical data.
Kaposi Sarcoma-associated Herpes Virus Targets the Lymphotactin Receptor with Both a Broad Spectrum Antagonist vCCL2 and a Highly Selective and Potent Agonist vCCL3*

Large DNA viruses such as herpesvirus and poxvirus encode proteins that target and exploit the chemokine system of their host. These proteins have the potential to block or change the orchestrated recruitment of leukocytes to sites of viral infection. The genome of Kaposi sarcoma-associated herpes virus (KSHV) encodes three chemokine-like proteins named vCCL1, vCCL2, and vCCL3. In this study vCCL3 was probed in parallel with vCCL1 and vCCL2 against a panel of the 18 classified human chemokine receptors. In calcium mobilization assays vCCL1 acted as a selective CCR8 agonist, whereas vCCL2 was found to act as a broad spectrum chemokine antagonist of human chemokine receptors, including the lymphotactin receptor. In contrast vCCL3 was found to be a highly selective agonist for the human lymphotactin receptor XCR1. The potency of vCCL3 was found to be 10-fold higher than the endogenous human XCL1 chemokine in respect to phosphatidylinositol turnover and calcium mobilization as well as chemotaxis. High expression of XCR1 was found in placenta and neutrophils by real-time PCR. These data are consistent with reports of different expression profiles for vCCL2 and vCCL3 during the life cycle of KSHV, indicate a novel, sophisticated exploitation by the virus of specifically the lymphotactin receptor by both agonist and antagonist mechanisms, and suggest a unique physiological importance of this (somewhat overlooked) chemokine receptor.
Family-based intervention improves maternal psychological well-being and feeding interaction of preterm infants.

OBJECTIVE To determine the efficacy of an individualized, family-based intervention with preterm infants and their families. DESIGN Randomized, repeated measures intervention outcome study. SETTING Level III neonatal intensive care nursery. PATIENTS Random sample of 34 preterm infants < or = 1500 g and their families. INTERVENTIONS Individualized, family-based intervention during the hospitalization and transition to home addressed problems identified by parents in four domains including: infant behavior and characteristics, family organization and functioning, caregiving environment, and home discharge and community resources. MEASUREMENTS AND MAIN RESULTS Standardized questionnaires were administered at baseline and discharge to mothers, and predischarge bottle-feeding interactions were videotaped and coded by two blinded observers. Results were in favor of intervention (Int) versus control (Con) mothers (baseline; discharge) (P < .05) on the Parental Stressor Scale Sights and Sounds subscale (Int 2.4 +/- 1.0; 2.0 +/- 0.8 vs Con 2.4 +/- 0.9; 2.6 +/- 0.8); Child's Appearance and Behavior subscale (Int 2.8 +/- 1.0; 2.5 +/- 1.1 vs Con 2.8 +/- 0.8; 3.1 +/- 0.6); and Total Stressor Score (Int 93.9 +/- 36.6; 72.3 +/- 41.8 vs Con 87.5 +/- 26.7; 87.8 +/- 26.2). On the Beck Depression Inventory, intervention mothers had significant decreases in depressive symptoms (39%; 11%) vs control mothers (31%; 44%). Maternal self-esteem in both groups improved over time. There were no significant group differences in family environment. During feeding interactions, intervention infants grimaced (P < .001) and gagged (P < .05) less than controls. Intervention mothers less frequently interrupted feedings (P < .001); less frequently stimulated infant sucking (P < .01); smiled more (P < .001); vocalized more (P < .01); demonstrated greater sensitivity to infant behavior (P < .001), better quality of physical contact (P < .001), and more positive affect (P < .01). CONCLUSIONS Individualized, family-based intervention appears to reduce maternal stress and depression, and to enhance early mother-infant feeding interactions. Further research is needed to determine whether these short-term beneficial effects persist beyond the newborn period.
Adenosine A2a receptors in the nucleus accumbens modulate prepulse inhibition of the startle response

PREPULSE inhibition (PPI) of the acoustic startle response (ASR) was disrupted by systemic administration of apomorphine (APO) (2 mg/kg, i.p.). Microinfusion of the selective adenosine A2a-receptor agonist CGS21680 (0.05 mg in 1.0 ml per side) into the nucleus accumbens (NAc), had no significant effect in animals with systemic vehicle pretreatment, but significantly reversed the disruption of PPI in rats pretreated with APO. Adenosine is, therefore, involved in the control of PPI through its actions on A2a receptors in the NAc. APO-induced disruption of PPI is considered to represent an animal model useful for screening both typical and atypical antipsychotic agents. The present results add further support to the view that A2a-receptor agonists may be potentially useful antipsychotic agents.
Design of a New Bandpass Filter Using Anti-Parallel Coupled Asymmetric SIRs

In this paper a newly designed internally-coupled asymmetric stepped-impedance resonator (SIR) bandpass filter (BPF) is proposed. The asymmetric SIR structure not only can effectively reduce the circuit size but also can provide two flexibly tunable transmission zeros near the lower and upper passband edges. The first transmission zero is due to the series resonance of the quarter-wavelength open stepped-impedance stub, and the second one is produced by anti-parallel coupling between adjacent SIRs. The proposed BPF was fabricated and simulated using the commercial software HFSS, and agreement between the measured and simulated results was observed. A 0.9-dB insertion loss and a shape factor of 3.6 were achieved in the passband, thus indicating that the proposed filter structure is of practical value.
Selective photoreactions in a programmable array microscope (PAM): Photoinitiated polymerization, photodecaging, and photochromic conversion

Innovative thinking and experimentation were the hallmarks of Mack Fulwyler's approach to research. This report summarizes some of the ideas and their early realizations that he pursued in the field of imaging cytometry, work that was not published before his untimely death, although he composed the initial draft of this report.
Acupuncture in a hospital setting in Argentina: users' experiences and perspectives

Indagamos las experiencias y perspectivas de los usuarios de un servicio hospitalario publico de acupuntura del noroeste argentino. Basamos el analisis en 18 entrevistas semi-estructuradas realizadas en el ano 2005. Los entrevistados recurren a la acupuntura por dolencias cronicas, especialmente como paliativo del dolor, aunque varios extienden su uso para otros problemas de salud, frente a la ineficacia y/o efectos adversos de los tratamientos biomedicos, o para evitar cirugias menores. Incorporan la acupuntura a estrategias pluralistas de cuidado que junto con la biomedicina incluyen tipicamente otras medicinas no convencionales. El contexto hospitalario facilita que prueben una medicina foranea. Varios usuarios encuentran el servicio de asesoramiento para "negociar" los tratamientos con sus medicos convencionales. Destacan la eficiencia organizativa del servicio y el compromiso de los medicos. Ante la demanda creciente de atencion en un contexto de escasez de recursos advierten que esta puede afectar la disponibilidad de turnos y la interaccion medico-paciente.
Dentate Filter Function Is Altered in a Proepileptic Fashion during Aging

Summary: Purpose: The elderly have an increased incidence and prevalence for seizure disorders. Further, since up to 50% of these cases have no identifiable antecedent, it has been hypothesized that aging of the central nervous system itself may be epileptogenic. Aged rats, compared to adults, exhibit a greater susceptibility to and severity of seizures associated with hippocampal activation. Whether this aging‐related change reflects proconvulsive changes in limbic circuitry is unknown and thus was the focus of this study.
An intelligent force control scheme for robotic applications : contact with non-rigid environments

This thesis describes an investigation into the use of a novel intelligent force control scheme that was developed to control the contact force between a mechanical manipulator's end-effector and a range of non-rigid contact environments. The scheme uses a Radial Basis Function (RBF) neural network to model idealised reaction to a range of environments, each with differing degrees of rigidity. During the development of the intelligent force control scheme's neural network, factors that may affect network performance were investigated, including aspects relating to network topology selection and RBF centre placement. Results presented show that a single RBF network was capable of modelling idealised reaction to a range of non-rigid environments to a high degree of accuracy. Once trained, the RBF network was incorporated into a single degree of freedom mechanical manipulator simulation that was developed in the Advanced Continuous Simulation Language and the control system's ability to apply forces to a range of nonrigid environments was investigated by simulation. Results presented demonstrate that satisfactory contact was achievable with a range of non-rigid environments without a priori knowledge of the contact environment's mechanical properties. The intelligent force control scheme's suitability for force application to varying environments was also investigated.
Decoder Assisted Channel Estimation and Frame Synchronization

In regards to turbo codes, to the author's knowledge, previous literature has treated decoder assisted frame synchronization and channel estimation as separate processes. Here a joint decoder assisted process of channel estimation and frame synchronization is proposed. In brief, the method entails using a sync word (SW) embedded mid-packet for both channel estimation and frame synchronization. The method will use a correlation-based frame synchronization that passes a list of possible delays to the turbo decoder. The turbo decoder will draw upon pilot symbol assisted modulation (PSAM) techniques for channel estimation using the coded SW.
The Renin Response to Diuretic Therapy: A Limitation of Antihypertensive Potential

We attempted to determine whether a diuretic-induced increase in renin secretion results in angiotensin II-mediated vasoconstriction which counteracts the antihypertensive action of diuretics. The angiotensui antagonist saralasin was administered to nine normal renin and five low renin essential hypertensives prior to and during stimulation of the renin-angiotendn system by 6 weeks of chronic diuretic therapy alone. Initial responses to saralasin infusion in all subjects on placebo varied, but were pressor overall. Following chronic polythiazide therapy, saralasin induced depressor responses of variable magnitude in seven of nine normal renin subjects. The combination of the diuretic and saralasin normalized blood pressure in four subjects. However, four normal renin subjects maintained a diastolic Mood pressure greater than 95 mm Hg despite simultaneous volume depletion and angiotensin blockade. One had a maximum antihypertensive effect with diuretic therapy alone. Pressor responses to saralasin persisted in four of five low renin subjects despite diuretic therapy. In general, the magnitude of the change hi plasma renin activity induced by diuretic therapy correlated with the difference in Mood pressure responses to saralasin. However, individual Mood pressure responses and absolute renin levels after diuretic therapy failed to predict consistently the ensuing responses to saralasin. Hence, in eight subjects (seven normal and one low renin), the compensatory increase in renin secretion hi response to diuretic-induced volume depletion limited diuretic antihypertensive efficacy. Yet diuretic-induced angiotensin dependency was not the sole mechanism supporting residual hypertension hi all subjects refractory to diuretic therapy.