Miracle-dz/UniFAR-FTUs huggingface dataset:
Systems Training for Emotional Predictability and Problem Solving (STEPPS) for outpatients with borderline personality disorder: a randomized controlled trial and 1-year follow-up.

OBJECTIVE Systems Training for Emotional Predictability and Problem Solving (STEPPS) is a 20-week manual-based group treatment program for outpatients with borderline personality disorder that combines cognitive behavioral elements and skills training with a systems component. The authors compared STEPPS plus treatment as usual with treatment as usual alone in a randomized controlled trial. METHOD Subjects with borderline personality disorder were randomly assigned to STEPPS plus treatment as usual or treatment as usual alone. Total score on the Zanarini Rating Scale for Borderline Personality Disorder was the primary outcome measure. Secondary outcomes included measures of global functioning, depression, impulsivity, and social functioning; suicide attempts and self-harm acts; and crisis utilization. Subjects were followed 1 year posttreatment. A linear mixed-effects model was used in the analysis. RESULTS Data pertaining to 124 subjects (STEPPS plus treatment as usual [N=65]; treatment as usual alone [N=59]) were analyzed. Subjects assigned to STEPPS plus treatment as usual experienced greater improvement in the Zanarini Rating Scale for Borderline Personality Disorder total score and subscales assessing affective, cognitive, interpersonal, and impulsive domains. STEPPS plus treatment as usual also led to greater improvements in impulsivity, negative affectivity, mood, and global functioning. These differences yielded moderate to large effect sizes. There were no differences between groups for suicide attempts, self-harm acts, or hospitalizations. Most gains attributed to STEPPS were maintained during follow-up. Fewer STEPPS plus treatment as usual subjects had emergency department visits during treatment and follow-up. The discontinuation rate was high in both groups. CONCLUSIONS STEPPS, an adjunctive group treatment, can deliver clinically meaningful improvements in borderline personality disorder-related symptoms and behaviors, enhance global functioning, and relieve depression.
Cancer esearch cular and Cellular Pathobiology A 1-Associated Epigenetic Regulation of p 73 Mediates an R ctor Pathway for Chemosensitivity in Ovarian Carcinoma

nloaded majority of tumors arising in BRCA1 mutation carriers exhibit inactivation of p53, a key effector of cell after DNA damage. Despite the loss of p53, BRCA1-deficient tumor cells exhibit increased sensitivity latin, and patients with BRCA1-associated ovarian carcinomas experience improved outcomes with um-based chemotherapy compared with sporadic cases. Although it is known that chemosensitivity A1-associated cancers is associated with unrepaired DNA damage, the specific effector pathway medihe cellular response to platinum-induced damage in these tumors is poorly understood. Here, we show e p53-related gene p73, encoding a proapoptotic protein that is linked to chemosensitivity in many gs, is upregulated through a novel epigenetic mechanism in both human and murine models of 1-associated ovarian carcinoma. BRCA1-deficient ovarian carcinoma cells exhibit hypermethylation a p73 regulatory region, which includes the binding site for the p73 transcriptional repressor ZEB1, g to the abrogation of ZEB1 binding and increased expression of transactivating p73 isoforms 3). Cisplatin chemotherapy induces TAp73 target genes specifically in BRCA1-deficient cells, and knockof TAp73 in these cells causes chemoresistance while having little or no effect on BRCA1-expressing cells. In primary ovarian carcinomas, ZEB1 binding site methylation and TAp73 expression correlate RCA1 status and with clinical response. Together, these findings uncover a novel regulatory mechanism pports the contribution of TAp73 as an important mediator of the response to platinum chemotherapy that su in a subset of ovarian carcinomas. TAp73 might represent a response predictor and potential therapeutic target for enhancing chemosensitivity in this disease. Cancer Res; 70(18); OF1–11. ©2010 AACR.
ACG Clinical Guideline: Ulcerative Colitis in Adults

Ulcerative colitis (UC) is an idiopathic inflammatory disorder. These guidelines indicate the preferred approach to the management of adults with UC and represent the official practice recommendations of the American College of Gastroenterology. The scientific evidence for these guidelines was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) process. In instances where the evidence was not appropriate for GRADE, but there was consensus of significant clinical merit, “key concept” statements were developed using expert consensus. These guidelines are meant to be broadly applicable and should be viewed as the preferred, but not only, approach to clinical scenarios.
Optimizing Tree Patterns for Querying Graph- and Tree-Structured Data

Many of today's graph query languages are based on graph pattern matching. We investigate optimization for treeshaped patterns with transitive closure. Such patterns are quite expressive, yet can be evaluated efficiently. The minimization problem aims at reducing the number of nodes in patterns and goes back to the early 2000's. We provide an example showing that, in contrast to earlier claims, tree patterns cannot be minimized by deleting nodes only. The example resolves the M ? /= NR problem, which asks if a tree pattern is minimal if and only if it is nonredundant. The example can be adapted to also understand the complexity of minimization, which was another question that was open since the early research on the problem. Interestingly, the latter result also shows that, unless standard complexity assumptions are false, more general approaches for minimizing tree patterns are also bound to fail in some cases.
The role of liquid–liquid phase separation in aggregation of the TDP-43 low-complexity domain

Pathological aggregation of the transactive response DNA-binding protein of 43 kDa (TDP-43) is associated with several neurodegenerative disorders, including ALS, frontotemporal dementia, chronic traumatic encephalopathy, and Alzheimer's disease. TDP-43 aggregation appears to be largely driven by its low-complexity domain (LCD), which also has a high propensity to undergo liquid–liquid phase separation (LLPS). However, the mechanism of TDP-43 LCD pathological aggregation and, most importantly, the relationship between the aggregation process and LLPS remains largely unknown. Here, we show that amyloid formation by the LCD is controlled by electrostatic repulsion. We also demonstrate that the liquid droplet environment strongly accelerates LCD fibrillation and that its aggregation under LLPS conditions involves several distinct events, culminating in rapid assembly of fibrillar aggregates that emanate from within mature liquid droplets. These combined results strongly suggest that LLPS may play a major role in pathological TDP-43 aggregation, contributing to pathogenesis in neurodegenerative diseases.
Surgery for Infective Endocarditis

Infective endocarditis (IE) remains a dangerous condition with unchanging incidence and a mortality approaching 30% at 1 year.1,2 Surgery is potentially lifesaving3 and is required in 25% to 50% of cases during acute infection and 20% to 40% during convalescence.4–7 Operative procedures are often technically difficult and associated with high risk, not least because patients are frequently extremely sick with multisystem disease. Nevertheless, indications for surgery are clear in many patients, and international guidelines8,9 provide strong recommendations that are applicable for the majority. These guidelines are not supported by robust clinical evidence, however, and clinical decision making is often hampered by diverse considerations, including advancing age of the overall patient cohort, the presence of extracardiac complications or preexistent comorbidity, prior antibiotic therapy of varying duration, and the availability of appropriate surgical expertise. In this article, we review the evidence base that supports current clinical practice and attempt to provide recommendations in areas where doubt persists.
Cryo-electron microscopy structure of the filamentous bacteriophage IKe

Significance The filamentous bacteriophage IKe is one of many nonenveloped bacterial viruses that encapsulate a circular single-stranded viral genome in the phage capsid shell. The shell of IKe is comprised of about 3,100 copies of the IKe major coat protein. Atomic-resolution structures of filamentous phages are scarce, and the structure of the single-stranded DNA is a matter of debate. Our cryo-electron microscopy structure of the filamentous bacteriophage IKe at a resolution of 3.4 Å provides atomic details on the structure of the major coat protein, the symmetry of the capsid shell, and the key interactions driving its assembly. We propose a model for the conformation of the circular single-stranded DNA core and the interactions between the capsid shell and inner DNA core. The filamentous bacteriophage IKe infects Escherichia coli cells bearing IncN pili. We report the cryo-electron microscopy structure of the micrometer-long IKe viral particle at a resolution of 3.4 Å. The major coat protein [protein 8 (p8)] consists of 47 residues that fold into a ∼68-Å-long helix. An atomic model of the coat protein was built. Five p8 helices in a horizontal layer form a pentamer, and symmetrically neighboring p8 layers form a right-handed helical cylinder having a rise per pentamer of 16.77 Å and a twist of 38.52°. The inner surface of the capsid cylinder is positively charged and has direct interactions with the encapsulated circular single-stranded DNA genome, which has an electron density consistent with an unusual left-handed helix structure. Similar to capsid structures of other filamentous viruses, strong capsid packing in the IKe particle is maintained by hydrophobic residues. Despite having a different length and large sequence differences from other filamentous phages, π–π interactions were found between Tyr9 of one p8 and Trp29 of a neighboring p8 in IKe that are similar to interactions observed in phage M13, suggesting that, despite sequence divergence, overall structural features are maintained.
Distribution of Chrysoporthe Canker Pathogens on Eucalyptus and Syzygium spp. in Eastern and Southern Africa.

Chrysoporthe cubensis and C. austroafricana, collectively known as Cryphonectria cubensis in the past, are important canker pathogens of Eucalyptus spp. worldwide. Previous studies have suggested that Chrysoporthe austroafricana occurs only in South Africa, whereas C. cubensis occurs in Australia, Cameroon, Tanzania, Democratic Republic of Congo, Republic of Congo, Southeast Asia, and South, Central, and North America. In South Africa, C. austroafricana is a pathogen on nonnative Eucalyptus (Myrtaceae) and Tibouchina (Melastomataceae) spp. , both residing in the order Myrtales. Recently, the fungus also has been found on native Syzygium cordatum trees in the country, leading to the hypothesis that it is native to Africa. In contrast, C. cubensis is thought to have been introduced into Africa and is known only on non-native Eucalyptus spp. and S. aromaticum (clove) in four countries. The aim of this study was to consider the distribution of Chrysoporthe spp. on non-native Eucalyptus spp. as well as on native Myrtales in southern and eastern Africa. Isolates were collected from as many trees as possible and characterized based on their morphology and DNA sequence data for two gene regions. Results show, for the first time, that C. cubensis occurs in Kenya, Malawi, and Mozambique on nonnative Eucalyptus spp. C. austroafricana was found for the first time in Mozambique, Malawi, and Zambia on non-native Eucalyptus spp. and native S. cordatum. The known distribution range of C. austroafricana within South Africa also was extended during these surveys.
Perfusion CT in acute stroke: a comprehensive analysis of infarct and penumbra.

PURPOSE To perform a large-scale systematic comparison of the accuracy of all commonly used perfusion computed tomography (CT) data postprocessing methods in the definition of infarct core and penumbra in acute stroke. MATERIALS AND METHODS The collection of data for this study was approved by the institutional ethics committee, and all patients gave informed consent. Three hundred fourteen patients with hemispheric ischemia underwent perfusion CT within 6 hours of stroke symptom onset and magnetic resonance (MR) imaging at 24 hours. CT perfusion maps were generated by using six different postprocessing methods. Pixel-based analysis was used to calculate sensitivity and specificity of different perfusion CT thresholds for the penumbra and infarct core with each postprocessing method, and receiver operator characteristic (ROC) curves were plotted. Area under the ROC curve (AUC) analysis was used to define the optimum threshold. RESULTS Delay-corrected singular value deconvolution (SVD) with a delay time of more than 2 seconds most accurately defined the penumbra (AUC = 0.86, P = .046, mean volume difference between acute perfusion CT and 24-hour diffusion-weighted MR imaging = 1.7 mL). A double core threshold with a delay time of more than 2 seconds and cerebral blood flow less than 40% provided the most accurate definition of the infarct core (AUC = 0.86, P = .038). The other SVD measures (block circulant, nondelay corrected) were more accurate than non-SVD methods. CONCLUSION This study has shown that there is marked variability in penumbra and infarct prediction among various deconvolution techniques and highlights the need for standardization of perfusion CT in stroke. SUPPLEMENTAL MATERIAL http://radiology.rsna. org/lookup/suppl/doi:10.1148/radiol.12120971/-/DC1.
Positioning, Navigation, and Book Accessing/Returning in an Autonomous Library Robot using Integrated Binocular Vision and QR Code Identification Systems

With rapid advancements in artificial intelligence and mobile robots, some of the tedious yet simple jobs in modern libraries, like book accessing and returning (BAR) operations that had been fulfilled manually before, could be undertaken by robots. Due to the limited accuracies of the existing positioning and navigation (P&N) technologies and the operational errors accumulated within the robot P&N process, however, most of the current robots are not able to fulfill such high-precision operations. To address these practical issues, we propose, for the first time (to the best of our knowledge), to combine the binocular vision and Quick Response (QR) code identification techniques together to improve the robot P&N accuracies, and then construct an autonomous library robot for high-precision BAR operations. Specifically, the binocular vision system is used for dynamic digital map construction and autonomous P&N, as well as obstacle identification and avoiding functions, while the QR code identification technique is responsible for both robot operational error elimination and robotic arm BAR operation determination. Both simulations and experiments are conducted to verify the effectiveness of the proposed technique combination, as well as the constructed robot. Results show that such a technique combination is effective and robust, and could help to significantly improve the P&N and BAR operation accuracies, while reducing the BAR operation time. The implemented autonomous robot is fully-autonomous and cost-effective, and may find applications far beyond libraries with only sophisticated technologies employed.
A Review of Curcumin and Its Derivatives as Anticancer Agents

Cancer is the second leading cause of death in the world and one of the major public health problems. Despite the great advances in cancer therapy, the incidence and mortality rates of cancer remain high. Therefore, the quest for more efficient and less toxic cancer treatment strategies is still at the forefront of current research. Curcumin, the active ingredient of the Curcuma longa plant, has received great attention over the past two decades as an antioxidant, anti-inflammatory, and anticancer agent. In this review, a summary of the medicinal chemistry and pharmacology of curcumin and its derivatives in regard to anticancer activity, their main mechanisms of action, and cellular targets has been provided based on the literature data from the experimental and clinical evaluation of curcumin in cancer cell lines, animal models, and human subjects. In addition, the recent advances in the drug delivery systems for curcumin delivery to cancer cells have been highlighted.
Comparison of the clinical and genetic features of amyotrophic lateral sclerosis across Cuban, Uruguayan and Irish clinic-based populations

Objectives This study compares the clinical characteristics of patients with amyotrophic lateral sclerosis (ALS) within three clinic-based populations from Cuba, Uruguay and Ireland and determines the impact of known ALS-associated genetic variants on phenotypic manifestations within the Cuban population. Methods Demographic and clinical information was collected on 115 Cuban, 220 Uruguayan and 1038 Irish patients with ALS attending national specialist clinics through 1996–2017. All Cuban patients and 676 Irish patients underwent next-generation DNA sequencing and were screened for the pathogenic C9orf72 repeat expansion. Results The mean age of onset was younger in the Cuban (53.0 years, 95% CI 50.4 to 55.6) and Uruguayan (58.2 years, 95% CI 56.5 to 60.0) populations compared with the Irish population (61.6 years, 95% CI 60.9 to 62.4). No differences in survival between populations were observed. 1.7 % (95% CI 0.6 to 4.1) of Cubans with ALS carried the C9orf72 repeat expansion compared with 9.9% (95% CI 7.8 to 12.0) of Irish patients with ALS (p=0.004). Other known variants identified in the Cuban population included ANG (one patient), CHCHD10 (one patient) and DCTN1 (three patients). Conclusions and relevance This study is the first to describe the clinical characteristics of ALS in Cuban and Uruguayan populations and report differences between the Cuban and Irish genetic signature in terms of known ALS-associated genetic variants. These novel clinical and genetic data add to our understanding of ALS across different and understudied populations.
The impact of curcumin and its modified formulations on Alzheimer's disease

Alzheimer's disease (AD) is a major health problem worldwide, with no effective treatment approach. Curcumin is the main ingredient of turmeric traditionally used in Asian medicine. Several experimental studies have indicated the protective effect of curcumin and its novel formulations in AD. Curcumin has antioxidant, anti‐inflammatory and neurotrophic activities, proposing a strong potential to prevent neurodegenerative diseases. However, there are no sufficient clinical trials to confirm curcumin use in AD patients. Low bioavailability following oral administration of curcumin limits its usage in human. The present study was designed to gather the effects of curcumin and its modified formulations in human and experimental models of AD.
Java and the IBM San Francisco Project

The San FranciscoTM project establishes a new paradigm for building business applications. The product, targeted for independent software vendors (ISVs), provides a distributed object infrastructure (foundation), common business objects (CBOs), and business process components (BPCs). Together, they provide a platform-independent business application foundation, ready for extension by ISVs to produce end-customer, business-critical applications. The San Francisco project is written almost entirely in JavaTM and to our knowledge is currently the largest Java development effort in the world. This paper provides an overview of the San Francisco project, with emphasis on the Java considerations of the product's development, the lessons learned, and our recommendations for future Java language maturity.
P‐wave morphology and multipolar intracardiac atrial activation to facilitate nonpulmonary vein trigger localization

Nonpulmonary vein (non‐PV) triggers of atrial fibrillation (AF) are targets for ablation but their localization remains challenging. The aim of this study was to describe P‐wave (PW) morphologic characteristics and intra‐atrial activation patterns and timing from multipolar coronary sinus (CS) and crista terminalis (CT) catheters that localize non‐PV triggers.
Antibody–Cytokine Fusions: Versatile Products for the Modulation of Anticancer Immunity

The remarkable clinical success of immune-checkpoint inhibitors for the treatment of a growing number of cancer types has sparked interest in the discovery of novel forms of immunotherapy, which may be used alone or in combination. In this context, cytokine-based therapeutics are well poised to play a role in modern cancer therapy. This article focuses on antibody–cytokine fusion proteins (also called “immunocytokines”) as one class of biopharmaceuticals that can substantially improve the therapeutic index and, thus, the applicability of cytokine products. In many preclinical settings, antibodies can be used to preferentially deliver many (but not all) types of cytokines to primary and metastatic tumor lesions. The antibody-based delivery of certain proinflammatory payloads (such as IL2, IL12, and TNF) to the tumor microenvironment can lead to a dramatic potentiation of their anticancer activity. However, although some fusion proteins have advanced to late-stage clinical trials, much work remains to be done in order to fully characterize the mechanism of action and the pharmaceutical potential of immunocytokines in the clinical setting. Various factors contribute to in vivo performance, including the target antigen, the antibody properties, the nature of the payload, the format of the fusion protein, the dose, and schedule, as well as their use in combination with other therapeutic modalities. Protein engineering opportunities and insights in cancer immunology are contributing to the development of next-generation immunocytokine products and of novel therapeutic concepts, with the goal to increase antitumor activity and reduce systemic toxicity (a common problem for cytokine-based biopharmaceuticals).
Parental bonding, adult attachment, and theory of mind: A developmental model of alexithymia and alcohol-related risk.

OBJECTIVE A developmental model of alexithymia in relation to alcohol-related risk was examined. METHOD Validated indices of parental bonding, adult attachment, alexithymia, theory of mind (ToM), alcohol-related risk, and mood were administered to a nonclinical sample of 286 alcohol-using men and women. RESULTS Hierarchical regression incorporating demographic and psychosocial variables accounted for 44% of the variance in alexithymia. Modeling indicated a significant path from dysfunctional maternal bonding to insecure adult attachment to alexithymia to risky drinking; a separate path indicated an indirect effect of alexithymia in association between the deficient ToM and risky drinking. CONCLUSIONS Findings were consistent with a developmental model where dysfunctional parental bonding in childhood manifests in adulthood as insecure attachment and alexithymia, the latter reflecting the insufficient acquisition of emotion regulation skills; alexithymia, in turn, increases the risk of problematic drinking as an emotion regulation strategy.