Miracle-dz/UniFAR-FTUs huggingface dataset:
The Cancer in Young People in Canada surveillance system.

Although childhood cancer remains the leading cause of disease-related deaths among children younger than 14 years of age, it is relatively rare.1,2 Each year, an average of 910 children are diagnosed with cancer in Canada, and 139 children die of the disease.3 Cancers in children differ biologically from those usually found in adults.4,5 The majority of cancers in adults are carcinomas of the epithelial tissues that line organs such as the breast, lung, colon and prostate. In children, carcinomas are rare and childhood tumours are more likely to be embryonic or hematopoietic in origin.5 Leukemias, lymphomas and central nervous system cancers represent the largest diagnostic groups.5 Compared to cancers in adults, cancers in children have shorter latency periods and are generally more aggressive, invasive and advanced at diagnosis.5 Despite the high ranking of cancer as a cause of death in children, survival rates have improved substantially over the last two decades so that more children survive cancer than ever before.6 However, over 60% of childhood cancer survivors face long-term physical and mental side-effects from the disease and its treatment, and nearly 30% have severe or life-threatening late effects.7 Survivors of childhood cancer have an 11-fold increased risk of death, an increased risk of second cancers up to 30 years after treatment and a wide variety of chronic physical, psychosocial and cognitive problems.8 The recognition of the unique nature of cancers in this age group and extensive long-term late effects has led many countries to establish specialized pediatric cancer surveillance and follow-up systems.8,9–11,13 In 2009, the Public Health Agency of Canada (PHAC) launched a pan-Canadian specialized childhood cancer surveillance system that actively follows children aged up to 14 years treated at one of the 17 pediatric oncology centres across the country (Table 1). The Cancer in Young People in Canada (CYP-C) program is a renewal of the federal government’s Canadian Childhood Cancer Surveillance and Control program (CCCSCP). Established under the Brighter Futures Initiative in 1992, the program includes comprehensive data on a child’s cancer diagnosis, treatments, outcomes and health care utilization.12,13 TABLE 1 Pediatric oncology centres participating in the Cancer in Young People in Canada surveillance system In this article, we describe the strengths and successes of CYP-C by highlighting rigour in data collection and quality control methodology as well as recent achievements and future directions.
Critical Protective Role for MCP-1 in Pneumonic Burkholderia mallei Infection

Burkholderia mallei is a Gram-negative bacterial pathogen of domestic equidae and humans that can cause severe, rapidly life-threatening pneumonic infections. Little is known regarding the role of chemokines and early cellular immune responses in protective immunity to pulmonary infection with B. mallei. Although the role of MCP-1 in Gram-positive bacterial infections has been previously investigated, the role of MCP-1 in immunity to acute pneumonia caused by Gram-negative bacteria, such as B. mallei, has not been assessed. In a mouse model of pneumonic B. mallei infection, we found that both MCP-1−/− mice and CCR2−/− mice were extremely susceptible to pulmonary infection with B. mallei, compared with wild-type (WT) C57Bl/6 mice. Bacterial burden and organ lesions were significantly increased in CCR2−/− mice, compared with WT animals, following B. mallei challenge. Monocyte and dendritic cell recruitment into the lungs of CCR2−/− mice was significantly reduced in comparison with that in WT mice following B. mallei infection, whereas neutrophil recruitment was actually increased. Depletion of monocytes and macrophages prior to infection also greatly raised the susceptibility of WT mice to infection. Production of IL-12 and IFN-γ in the lungs after B. mallei infection was significantly impaired in both MCP-1−/− and CCR2−/− mice, whereas treatment of CCR2−/− mice with rIFN-γ restored protection against lethal challenge with B. mallei. Thus, we conclude that MCP-1 plays a key role in regulating cellular immunity and IFN-γ production following pneumonic infection with B. mallei and therefore may also figure importantly in other Gram-negative pneumonias.
T-cell effector functions: mechanisms for delivery of cytotoxicity and help.

INTRODUCTION 480 EFFECTOR-TARGET IN TERACTION . 481 Recognition and Adherence. 481 The Surface Distribution of the TCR, CD4, and LFA -J in Effector-TC Conj ugates. 482 Intracellular Polarization in the Eff ector Cells During Ef ector-Target Cell Interact ion . 483 Cy TOTOXICITy 486 The First Pathway o f Cytotoxicity 486 The Second Pathway of Cytotoxicity . 487 The Third Pathway of Cytotoxicity . 487 The Fourth Pathway o f Cytotoxicity . 487 Target Cell Death: Execution or Induction of Suicide? 489 VECTORIAL SECRETION OF CYTOTOXIC GRANULES 490 COMPOSITION OF CYTOLYTIC GRANULES 490 The Complexity of Cytolytic Granules and Possible Functional Consequences 490 Granule Proteins. 493 PERFORIN EXPRESSION AND CTL MATURATION 495 PERFORIN EXPRESSION IN VIVO 498 THE PERFORIN GEN E . 499
Adhesion molecules and related proteins in Darier's disease and Hailey–Hailey disease

Summary We have used antibodies to plakoglobin and E‐cadherin: the lectins, peanut agglutinin (PNA) and soybean agglutinin (SBA); and sera from patients with the autoimmune diseases pemphigus vulgaris (PV) or pemphigus foliaceus (PF), in an immunohistological study of Darier's disease and Hailey–Hailey disease. There was normal expression of plakoglobin, E‐cadherin, lectins and pemphigus antigens at the periphery of keratinocytes in uninvolved skin. Clumps of plakoglobin were detected within acantholytic cells in Hailey–Hailey disease, whereas expression was diffuse in acantholytic cells in Darier's disease. This difference may reflect differences in the pathogenesis of acantholysis. E‐cadherin expression was weak or absent at the periphery of some acantholytic cells; lectin binding was sometimes reduced around acantholytic cells, and pemphigus antibodies did not bind to the acantholytic cells in involved skin in either disease. Internalization, conformational changes or proteolysis may alter the expression of extracellular epitopes by acantholytic cells.
Il parco come prodotto turistico

Tourism is an immaterial and intangible product, is the result of environmental and structural elements. According to the tourism in the wealth of every tourist destination in its overall size and contemporary can be communicated only through cooperation with operators who daily live and enliven the area. The area represents an opportunity to explore the basis of different levels of interest and tourist a chance to have real contact with lifestyles other than their own, experiencing profound experiences of knowledge in terms of aesthetic, intellectual or emotional. The offer must be, therefore, segmented, differentiated and specialized. It should not be offered a unique product, but how many products can be the interests and methods of use identified. The identity of a destination can not be uniquely determined but depends on different segments of tourists and the various offers. You must move in a perspective of soft tourism.
Unraveling the Function of FTO Variants.

Body-mass index (BMI), which represents a complex trait with high heritability, is a clinically relevant surrogate for obesity.1 Genomewide association studies have identified nearly 10,000 genetic polymorphisms in single-nucleotide variants (SNVs) associated with various human disorders and traits. However, approximately 90% of these variants are in genomic regions that do not map to coding regions and, therefore, do not directly affect protein synthesis or translation.2 However, risk-associated loci containing noncoding variants can alter gene expression by modulating the activity of neighboring cis-regulatory elements — that is, noncoding DNA sequences in or near a gene that can modify the expression .
Appropriateness of sham or placebo acupuncture for randomized controlled trials of acupuncture for nonspecific low back pain: a systematic review and meta-analysis

Objectives To establish whether sham acupuncture (SA) or placebo acupuncture (PA) is more efficacious for reducing low back pain (LBP) than other routine treatments and to discuss whether SA or PA is appropriate for randomized controlled trials of acupuncture for LBP. Methods Six databases were searched on 31 May 2017. We included only randomized controlled trials of adults with LBP and lower back myofascial pain syndrome. The studies had at least two control arms: a sham-controlled acupuncture arm and a routine care or waiting list arm (people who did not receive acupuncture until the end of treatment). Trials were combined using meta-analysis methods when the data allowed statistical pooling. Pooled effect sizes were calculated by random effects models. Results This review identified 7 trials (1768 participants); all were included in the meta-analysis. We found statistically significant differences in pain reduction post-intervention between SA or PA and routine care or a waiting list, with a standardized mean difference of −0.36 (95% CI −0.54 to −0.18; I2 statistic=16%; participants=624; studies=6) for the Visual Analog Scale and −0.35 (95% CI −0.49 to −0.20; I2 statistic=0%; participants=736; studies=1) for the Chronic Pain Grade Scale; however, no significant difference was observed between SA or PA and routine care or no treatment for post-intervention function. Conclusion Compared with routine care or a waiting list, SA or PA was more efficacious for pain relief post-intervention. Concluding that SA or PA is appropriate for acupuncture research would be premature. Guidelines evaluating SA or PA control methods are needed to determine the specific effect of acupuncture over placebo.
The Valuation of Social Media Public Companies: There Is a Method to This Madness!

The valuations of exchange listed social media companies have for long defied established corporate finance metrics and (in many instances) common sense. Besides highlighting theoretical and practical challenges related to valuing social media companies, this paper revisits the valuation metrics of all the global social media companies making up the most established social media benchmark (the Solactive Social Media Index, “SOCL”). The paper also reviews the investment case for social media against the backdrop of other equity markets. Thus far, global social media stocks have underperformed both the broad U.S. equity index (the Standard & Poor’s 500) and its technology subset (the NASDAQ Composite), while demonstrating a relatively high degree of volatility. Despite ongoing convergence with the broad U.S. equity universe, SOCL’s valuations indicate substantial premia over the Standard & Poor’s 500. This leads us to believe that any successful investment strategy focused on social media should be highly selective (based on stock picking rather than composite exposure to the industry).
Analysis of Network Effect in Port and Shipping System characterized by scale-free network

Based on the brief summarization of the development, properties and representative research achievements of scale-free networks, the paper makes an empirical analysis in some complex network characteristics of global shipping lines network. Taking port as dominant products, and shipping service, its complementary products, the mechanism of network effect in products system is analyzedby the study of two-stage budgeting procedure. Then, the paper presents that some complex network characters in a certain domain come from the influence of network benefits in the products network.
An enjoyable shopping experience enhances store loyalty

Nowadays, the increasing number of people travelling for business and holiday has brought marketers to identify an emerging and interesting target of consumers, defined as “On the Move”, willing to make their purchases in the travel context. This new shopping trend is driving managers of concessions of services areas on the motorwaysto extend their business from Food and Beverage (F&B)to grocery retailing. The main contributionthis paper aims to provide is the conceptualization and validation of a structural model in which Store Loyalty is explained through its main antecedents:Trustand Satisfaction, as well as less studied constructs: Enjoymentand Convenience, in the dual meaning of Search Convenience and Transaction Convenience. 606 questionnaire were collected from a sample of “On the Move” consumers.The Structural Equation Modelexhibits a good fit, and explains almost the 66% of store loyalty. Findings show that a pleasant and enjoyable shopping experience positively affects store loyalty. Furthermore, search convenience shows a positive effect on loyalty, while the transaction convenience negatively affects loyalty. Finally, results showthat theeffect of satisfaction on loyalty is completely mediated by trust. Retailers in their pursuit of retaining customers should look forward in implementing strategies that allow an enjoyable shopping experience, easy and quick to perform. Furthermore, satisfied customers would trust the retailer’s core offer positively, affecting their store loyalty level.
Global Health Clinical Education: Conducting a Community Needs Assessment for Evidence Based Intervention

Global health is the study and practice of improving health and health equity for all people worldwide through international and interdisciplinary collaboration. Studies suggest that health professions students benefit significantly through participating in global health clinical courses. This exploratory qualitative study conducted a community needs assessment as part of a global health clinical course for health professional students. The clinical course allowed students to plan and implement a week-long clinic providing primary health care to families in remote villages in Central America. Students engaged with the researcher to conduct a community assessment. As part of the community assessment we interviewed Kuna to identify from within the community the needs of families to improve health outcomes. This assessment was designed to provide empirical evidence to support future long-term, sustainable improvements in the health of communities. Findings indicate a chasm between what providers see as problems and villagers’ identified priorities. Despite many unanticipated challenges, this research produced some modest and tentative recommendations proposed both for the community and global health clinical education.
[Naringin inhibits monocyte adhesion to high glucose-induced human umbilical vein endothelial cells].

OBJECTIVE To investigate the inhibitory effect of naringin on monocyte adhesion to high glucose-induced human umbilical vein endothelial cells (HUVECs). METHODS Cultured HUVECs isolated from human umbilical cords were pretreated with or without naringin and induced with high glucose (33 mmol/L) for 48 h. Human monocyte THP-1 cells, after labeling with BCECF-AM, were co-cultured with the HUVECs for 30 min. The labeled THP-1 cells adhering to HUVECs were observed under fluoroscence microscope, and the inhibitory effect of naringin on the cell adhesion was evaluated by measuring the adhering cell density. Western blot analysis was used to detect the expressions of the adhesion molecules in the HUVECs, and reactive oxygen species (ROS) production in the HUVECs was measured using an oxidation-sensitive fluorescent probe (DCFH-DA). The nuclear extracts of the HUVECs were prepared to examine the expression of nuclear factor-kappa B (NF-kappaB) in the cell nuclei by Western blotting. RESULTS HUVECs in high-glucose culture showed increased adhesion to THP-1 cells and enhanced expressions of the cell adhesion molecules, which were significantly attenuated by pretreatment with naringin (10-50 microg/ml). High glucose induced DCF-sensitive intracellular ROS production in the HUVECs, and this effect was inhibited by naringin pretreatment of the cells. Naringin also suppressed high glucose-induced increment of NF-kappaB expression in the cell nuclei of HUVECs. CONCLUSION Naringin can suppress high glucose-induced vascular inflammation possibly by inhibiting ROS production and NF-kappaB activation in HUVECs.
Supply chain characteristics and disruption mitigation capability: an empirical investigation in China

This research investigates the impact of supply chain characteristic factors on disruption mitigation capabilities. We intend to derive specific supply chain factors that either contribute to or conversely impact a firm's supply chain disruption mitigation capabilities. We find that supply chain geographic dispersion has a negative impact on a firm's disruption mitigation capabilities. Supply chain agility has a positive impact on a firm's disruption recovery capability. Supply chain integration has direct positive impacts on a company's disruption warning capability and recovery capability. And supply chain visibility enhances a company's disruption warning capability. In addition, high level of disruption warning capability enhances a company's disruption recovery capability. The results offer guidelines for supply chain managers to enhance disruption mitigation capabilities through understanding the role of supply chain characteristic factors.
A neural network based technique to locate and classify microcalcifications in digital mammograms

This paper proposes a technique that extracts suspicious areas containing microcalcifications in digital mammograms and classifies them into two categories whether they contain benign or malignant clusters. The centroids and radiuses provided by expert radiologist are being used to locate and extract suspicious areas. Neural network's generalisation abilities are used to classify them into benign or malignant. The technique has been implemented in C++ on the SP2 supercomputer. The database from the Department of Radiology at the University of Nijmegen and Lawrence Livermore National Laboratory has been used for the experiments. The preliminary results are very promising. Some of them are presented in this paper.
Asset Market Correlation and Stress Testing: Cases for Housing and Stock Markets

This study aims to achieve a two-fold research objective: first, to econometrically investigate hypothesized linkages between real estate and stock markets by fitting different classes of time-varying volatility model; second, to perform VaR-type stress testing by using the fitted asset price models. In so doing, we use data from Korea and U.S. so that asset price processes, in terms of mean, volatility, correlation, can be compared. In the econometric analyses, we estimate both a multivariate GARCH model that allows contemporaneous and time-varying shock correlations between real estate and stock markets and an univariate GARCH model that does not allow such correlation. Our results indicate that housing price volatilities in both countries are highly time-varying, with the Korean asset markets shown to be more volatile, and that non-consideration of asset market correlation under-predicts the risk embedded in real estate price dynamics. Policy implications of our findings in regard to stress testing and other issues are also discussed.
Automatic detection of inertial sensor orientation for movement analysis in Parkinson's disease

To analyze the gait of Parkinson's patients and to objectively rate their disease stage development all over the day, low cost inertial sensors can be used. A current challenge is to deal with the potentially unknown sensor position. When measurements are recorded over a longer time period and in an unsupervised environment, sensor position can vary. Therefore, it is necessary to detect the orientation of the sensors. In this study, an algorithm for the automatic orientation detection of an inertial sensor placed on the instep is presented. The detected orientation was used for a subsequent transformation of the sensor data to the coordinate system of recorded reference data. The systems showed a correlation of up to 0.99. Afterwards, a step segmentation of the recorded walking data was computed. Conclusively, the results of a sagittal angle comparison of the transformed gait data of different population groups are shown. With the presented methods, the feasibility of unsupervised long term monitoring of PD patients in daily life is increased.
Specificity of symptoms of depression in Alzheimer disease: a longitudinal analysis.

OBJECTIVE Authors examined the temporal stability of symptoms of major and minor depression and apathy in dementia. METHODS A consecutive sample of 65 patients with Alzheimer disease (AD) and depression at baseline evaluation received a follow-up psychiatric assessment that included the Structured Clinical Interview for DSM-IV and the Hamilton Rating Scale for Depression an average of 17 months later. RESULTS Half of the sample had no depression at follow-up, and showed a significant improvement in sadness, guilt, suicidal ideation, disruption in sleep, loss of interest, loss of energy, thoughts of death, social withdrawal, psychomotor changes, changes in appetite/weight, and symptoms of anxiety. No significant changes were found on scores of irritability or apathy. CONCLUSIONS The study demonstrates the specificity of depressive symptoms in AD and suggests that apathy and depression are different behavioral domains.
Contribution of loads to low frequency oscillations in power system operation

Eigen-based tools have normally been used to predict the development of low frequency oscillation in power systems. A method must be developed to study the effect of loading and load characteristics on the development of low frequency oscillations. This paper is concerned about modeling a power system for low frequency oscillations studies. The purpose is to examine the effect of loads and their modeling on the study mentioned. Research shows that low frequency oscillations are a small signal stability problem. This allows the use of Eigenvectors and Eigenvalues to examine the stability of the power system in the advent of load variation. In this study a mathematical model of the dynamic power system must be built and the initial values of the variables in the model calculated using a load flow. The power system model consists of the non-linear equations which must be linearized about the operating values of the system. The system state matrix can then be constructed from the linearized power system model. Software was written in Matlab 7.0 to perform these mentioned computations. This paper also uses tools such as Participation factors and Mode shape. These tools were useful in examining the effect of loads on the system stability.