Miracle-dz/UniFAR-FTUs huggingface dataset:
One MRI‐compatible tDCS session attenuates ventromedial cortical perfusion when exposed to verbal criticism: The role of perceived criticism

Transcranial direct current stimulation (tDCS) is a potential treatment strategy for mood and anxiety disorders, but how this application may influence emotional processes, and whether this is related to individual characteristics, is not well understood. It has been proposed that perceived criticism (PC) may represent a vulnerability factor for the development of such mental illnesses. To decipher whether neural mechanisms of action of tDCS potentially differ depending on PC status (low vs. high), we evaluated mood and brain perfusion before and after applying MRI‐compatible tDCS, and after participants were exposed to verbal criticism in the scanner. Experimental design 30 healthy nondepressed females were included in a sham‐controlled crossover MRI‐compatible tDCS study. Brain perfusion was measured by means of arterial spin labeling (ASL) before and after tDCS applied to the left dorsolateral prefrontal cortex (DLPFC), and after hearing criticism. Before the experiment, all participants provided a rating of PC in their closest environment. Principal observations at the behavioral level, criticism made participants angrier. This was unrelated to the active or sham stimulation. After being criticized, females scoring high on PC had significantly decreased brain perfusion in the pregenual anterior cingulate cortex (pgACC) and medioprefrontal cortex (mPFC), after active tDCS but not sham. The decrease in pgACC/mPFC perfusion points to a significant impact of tDCS in brain areas related to stress responses and self‐referential processes, especially in females scoring high on PC, which has been shown to be related to vulnerability for mood and anxiety disorders.
The Research and Implement of Food Electronic Monitoring System Based on WSN

This study realized the design of wireless sensor network food monitoring system based on WSN using Zigbee technology and RSSI ranging technology. Food safety monitoring and control system is designed to control a market point module for the establishment and management of the design and implementation of two modules. Modern micro sensor has low cost, low power characteristic, it can realize the wireless communication and computing performance, a large number of the sensors organizations constitute the wireless sensor network. The system has been tested and established on the basis of the system architecture.
A Well-Researched Book in Search of an Audience: Making Sense of Genes by Kostas Kampourakis

Making Sense of Genes is a new book by Kostas Kampourakis that offers a well-researched commentary on the strengths and limitations of genetics. The book may be too scientifically complex and too one-sided in its opinions to assign to undergraduate students, but it is a provocative and useful read for instructors planning a genetics course.
An introduction to Occam and the development of parallel software

Most people's knowledge of Occam? derives from their interest in the Inmos? Transputer. Occam is the language of the Transputer, the two having been developed hand-in-hand by Inmos. Although most of the initial applications of Occam have been concerned with extracting the maximum performance from multiple Transputer-based architectures, it should be pointed out that Occam is not an assembly-level language. Occam is a high-level language with many points to recommend it in its own right. The Transputer has made Occam commercially viable, but, even without the Transputer, Occam would have attracted a considerable amount of interest. This article provides an introduction to Occam and, where applicable, compares and contrasts it with Ada*. Occam is far simpler that Ada, but the two languages do have similarities. The models of concurrency in both Ada and Occam were derived from Hoare's work on Communicating Sequential Processes(CSP) [3]. and both languages have been developed for use in real-time embedded systems [4].
Gamification experience of an educational environment in software engineening: Gamifying a course of agility for software process improvement

In the last decade gamification has become as a useful strategy for make work environments more dynamic, specifically because it supports initiatives associated with the increase of performance characteristics of work teams such as motivation and commitment. In addition, in work areas such as education, gamification has spread as a useful strategy for make the classroom more dynamic. On the other hand, in the area of software engineering, the performance and productivity of the work team have been identified as key success factors, with motivation being an essential factor in achieving this success. Therefore, there is an important growth of gamification strategies in the classroom as alternatives to increase the motivation and commitment of the work teams. However, the existing teaching strategies in software engineering omit certain details about how to structure a possible learning environment, such as the classroom. In this work a methodological structure is proposed to gamify an educational environment of software engineering. The objective of this proposal is to contribute to the decrease of causes of failure of software development projects within which is the lack of motivation and commitment as well as social and human factors that affect processes related to software engineering. An example of activities developed in a course of agility for software process improvement of the Universidad de Medellín is presented. The methodological structure proposed was designed using technological tools and web 2.0 tools that managed to accompany the teaching-learning process taking into account defined gamification principles.
CAEP POSITION STATEMENT DÉCLARATION DE L ’ ACMU Canadian Association of Emergency Physicians Position Statement on Acute Ischemic Stroke

The CAEP Stroke Practice Committee was convened in the spring of 2013 to revisit the 2001 policy statement on the use of thrombolytic therapy in acute ischemic stroke. The terms of reference of the panel were developed to include national representation from urban academic centres as well as community and rural centres from all regions of the country. Membership was determined by attracting recognized stroke leaders from across the country who agreed to volunteer their time towards the development of revised guidance on the topic. The guideline panel elected to adopt the GRADE language to communicate guidance after review of existing systematic reviews and international clinical practice guidelines. Stroke neurologists from across Canada were engaged to work alongside panel members to develop guidance as a dyad-based consensus when possible. There was no unique systematic review performed to support this guidance, rather existing efficacy data was relied upon. After a series of teleconferences and face to face meetings, a draft guideline was developed and presented to the CAEP board in June of 2014. The panel noted the development of significant new evidence to inform a number of clinical questions related to acute stroke management. In general terms the recommendations issued by the CAEP Stroke Practice Committee are supportive of the use of thrombolytic therapy when treatment can be administered within 3 hours of symptom onset. The committee is also supportive of system-level changes including pre-hospital interventions, the transport of patients to dedicated stroke centers when possible and tele-health measures to support thrombolytic therapy in a timely window. Of note, after careful deliberation, the panel elected to issue a conditional recommendation against the use of thrombolytic therapy in the 3–4.5 hour window. The view of the committee was that as a result of a narrow risk benefit balance, one that is considerably narrower than the same considerations under 3 hours, a significant number of informed patients and families would opt against the risk of early intracranial hemorrhage and the possibility of increased 90-day mortality that is not seen for more timely treatment. Furthermore, the frequently impaired nature of patients suffering an acute stroke and the difficulties in asking families to make life and death decisions in a highly time-sensitive context led the panel to restrict a strong endorsement of thrombolytic to the 3 hour outermost limit. The committee noted as well that Health Canada has not approved a thrombolytic agent beyond a three hour window in acute ischemic stroke.
Lung histopathology of non‐infectious pulmonary complications after allogeneic haematopoietic stem cell transplantation

Non‐infectious pulmonary complications (NIPCs) occur frequently following allogeneic haematopoietic stem cell transplantation (HSCT). As there is no consensus on the description of the related pulmonary pathological lesions, pathologist reports and clinical conclusions are largely inconsistent in routine practice. The aim of our study was to provide an accurate overview of post‐allogeneic HSCT NIPCs from a large number of lung biopsies.
MicroRNA‐19 restores vascular endothelial cell function in lower limb ischemia‐reperfusion injury through the KLF10‐dependent TGF‐β1/Smad signaling pathway in rats

Ischemia‐reperfusion injury (IRI) is a severe problem patients diagnosed with acute limb ischemia. Recently, microRNAs (miR) have emerged as regulators of IRI as well as ischemic preconditioning and ischemic postconditioning. Therefore, using rat models, this study aims to explore all of the possible mechanisms that miR‐19 exhibits with its relation to the transforming growth factor beta (TGF‐β1)/Smad signaling pathway in the lower limb IRI. An immunofluorescence staining method was used to identify the Krueppel‐like factor 10 (KLF10) positive expression and the location of KLF10 expression. The targeting relationship that miR‐19 has with KLF10 was verified by the dual‐luciferase reporter gene assay. Vascular endothelial cells (VECs) were treated with elevated or suppressed miR‐19 or KLF10 knockdown. A 3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyltetrazolium bromide assay was used to test cell proliferation, and flow cytometry was employed to detect both cell cycle and apoptosis. The KLF10‐positive expression in the VECs (both in cytoplasm and nucleus) was found to be elevated in the IRI rats. We found that miR‐19 was downregulated, KLF10 upregulated, and the TGF‐β1/Smad signaling pathway activated in the vascular epithelial tissues of IRI rats. KLF10 is a target gene of miR‐19. Overexpression of miR‐19 decreased the expression of KLF10, TGF‐β1, and Smad2/3. Decreased miR‐19 inhibited VEC proliferation, arrested VECs at the G1 phase, and promoted the apoptosis of VECs following their lower limb I/R injury. These results indicate miR‐19 as being an inhibitor in the VEC injury of IRI via the TGF‐β1/Smad signaling pathway by suppression of KLF10.
Diet-induced β-cell insulin resistance results in reversible loss of functional β-cell mass

Although convincing in genetic models, the relevance of β‐cell insulin resistance in diet‐induced type 2 diabetes (T2DM) remains unclear. Exemplified by diabetes‐prone, male, C57B1/6J mice being fed different combinations of Western‐style diet, we show that β‐cell insulin resistance occurs early during T2DM progression and is due to a combination of lipotoxicity and increased β‐cell workload. Within 8 wk of being fed a high‐fat, high‐sucrose diet, mice became obese, developed impaired insulin and glucose tolerances, and displayed noncompensatory insulin release, due, at least in part, to reduced expression of syntaxin‐1A. Through reporter islets transplanted to the anterior chamber of the eye, we demonstrated a concomitant loss of functional β‐cell mass. When mice were changed from diabetogenic diet to normal chow diet, the diabetes phenotype was reversed, suggesting a remarkable plasticity of functional β‐cell mass in the early phase of T2DM development. Our data reinforce the relevance of diet composition as an environmental factor determining different routes of diabetes progression in a given genetic background. Employing the in vivo reporter islet–monitoring approach will allow researchers to define key times in the dynamics of reversible loss of functional β‐cell mass and, thus, to investigate the underlying, molecular mechanisms involved in the progression toward T2DM manifestation. —Paschen, M. , Moede, T. , Valladolid‐Acebes, I. , Leibiger, B. , Moruzzi, N. , Jacob, S. , García‐Prieto, C. F. , Brismar, K. , Leibiger, I. B. , Berggren, P.‐O. Diet‐induced β‐cell insulin resistance results in reversible loss of functional β‐cell mass. FASEB J. 33, 204–218 (2019). www.fasebj. org
Operational dashboard implementation for a family taxi business company

This article describes a project that aimed to implement an operational dashboard to improve the management of a family-run taxi company. In the day-to-day life of the company, it lacked an operational tool that allowed a clear and integrated vision of the Taxi daily activity and that could be the driver for a quick decision-making, with the goal of improving the efficiency and effectiveness of the company, obtain higher productivity and less operating costs. No additional monetary investment was intended. The solution chosen is based on Google Forms for collecting data by the taxi driver, which is later recorded on Google Drive cloud. This up-to-date information is accessed in real time by a dynamic Microsoft Excel link using Power Query, being the final dashboard located in a refreshable Excel file hosted by Google Drive cloud service.
Rigid registration of different poses of animated shapes

Different poses of 3D models are very often given in different positions and orientations in space. Since most of the computer graphics algorithms do not satisfy geometric invariance, it is very important to bring shapes into a canonical coordinate frame before any processing. In this paper we consider the problem of finding the best alignment between two or more different poses of the same object represented by triangle meshes sharing the same connectivity. Firstly, we developed a method to select a region of interest (ROI) which has a perfect alignment over the two poses (up to a rigid movement). Secondary, we solved a simplified version of the Largest Common Point-set (LCP) problem with a-priori knowledge about point correspondence, in order to align the ROIs. We eventually align the poses performing least square rigid registration. Our method makes no assumption about the starting positions of the objects and can also be used with more than two poses at once. It is fast, non-iterative, easy to reproduce and brings the poses into the best alignment whatever the initial positions are.
Testing the Dutilleul syndrome: host use drives the convergent evolution of multiple traits in parasitic wasps

Common life‐history aspects among independent lineages often result in the repeated evolution of suites of adaptive traits, or ‘syndromes’. Such syndromes can be key avenues to understand relationships between morphological and ecological traits, but are rarely tested due to insufficient trait shift repetitions. We use a hyperdiverse lineage to investigate the evolution of a syndrome. Cryptine ichneumonid wasps that parasitize insects concealed in hard substrates display several traits that are putative adaptations to that end. Using a phylogenetic framework from a combined multigene molecular and morphological data set with 308 cryptine species, we tested whether these traits were part of a morphofunctional syndrome related to host use. Ancestral state estimations show multiple origins for six investigated traits, which are correlated to each other and to the use of deeply concealed hosts, suggesting adaptation. Putatively adaptive traits showed a much stronger link among themselves than with an assemblage of 49 other morphological traits. However, estimation of the order of evolution in adaptive traits showed no structured pattern. The results indicate that the challenge of attacking deeply concealed hosts induced the repeated evolution of a ‘Dutilleul syndrome’, named after the ‘walker‐through‐walls’ character from French literature. They also point towards a dynamic scenario in the evolution of complex functional systems. These findings highlight the power of morphology to illuminate poorly known aspects of natural history, and how hyperdiverse lineages can be used to understand the evolution of complex traits.
Downregulation of TRIM58 expression is associated with a poor patient outcome and enhances colorectal cancer cell invasion

TRIM58 is a member of the tripartite motif protein (TRIM) family of E3 ubiquitin ligases. Aberrant gene methylation of TRIM58 has been reported in liver and lung cancer and indicates a poor patient prognosis. However, the expression level and functional role of TRIM58 in colorectal cancer (CRC) have yet to be elucidated. In the present study, we found that TRIM58 expression was significantly suppressed in human CRC and was inversely correlated with CRC progression. Additionally, overall survival was significantly reduced in patients with low TRIM58 expression in CRC tumors. In vitro studies demonstrated that ectopic TRIM58 overexpression strongly inhibited CRC cell invasion but had minimal effects on cell proliferation, colonization and migration. Furthermore, TRIM58 suppression enhanced the expression of epithelial-to-mesenchymal transition (EMT) and matrix metalloproteinase (MMP) genes. Thus, our findings suggest that TRIM58 is a potential prognostic marker of CRC and functions as a tumor-suppressor gene via inhibition of cancer cell invasion through EMT and MMP activation.
Histological examination of post-mortem brains of children with nodding syndrome.

We read with interest the editorial by Boivin about the aetiology of nodding syndrome (1). In this paper the author mentions that histological examination of postmortem brains of children with nodding syndrome revealed polarizable material which proved difficult to characterize or identify in the majority of specimens (1). We recently performed a post-mortem study on a person with nodding syndrome in Uganda but we did not observe polarized material in the brain.
Valproic acid inhibits the protective effects of stromal cells against chemotherapy in breast cancer: Insights from proteomics and systems biology

Interaction between tumor and stromal cells is beginning to be decoded as a contributor to chemotherapy resistance. Here, we aim to take a system‐level approach to explore a mechanism by which stromal cells induce chemoresistance in cancer cells and subsequently identify a drug that can inhibit such interaction. Using a proteomic dataset containing quantitative data on secretome of stromal cells, we performed multivariate analyses and found that bone‐marrow mesenchymal stem cells (BM‐MSCs) play the most protective role against chemotherapeutics. Pathway enrichment tests showed that secreted cytokines from BM‐MSCs activated 4 signaling pathways including Janus kinase‐signal transducer and activator of transcription, phosphatidylinositol 3‐kinase‐protein kinase B, and mitogen‐activated protein kinase, transforming growth factor‐β in cancer cells collectively leading to nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐kB) transcription factor activation. Based on the data from integrated Library of Integrated Network‐Based Cellular Signatures (iLINCs) program, we found that among different drugs, valproic acid (VA) affected the expression of 34 genes within the identified pathways that are activated by stromal cells. Our in vitro experiments confirmed that VA inhibits NF‐kB activation in cancer cells. In addition, analyzing gene expression data in patients taking oral VA showed that this drug decreased expression of antioxidant enzymes culminating in increased oxidative stress in tumor cells. These results suggest that VA confines the protective role of stromal cells by inhibiting the adaptation mechanisms toward oxidative stress which is potentiated by stromal cells. Since VA is an already prescribed drug manifesting anticancer effects, this study provides a mechanistic insight for combination of VA with chemotherapy in the clinical setting.
Assessing Novel Drugs and Radiation Technology in the Chemoradiation of Oropharyngeal Cancer

Integrating immunotherapy, proton therapy and biological dose escalation into the definitive chemoradiation of oropharyngeal cancer poses several challenges. Reliable and reproducible data must be obtained in a timely fashion. However, despite recent international radiotherapy contouring guidelines, controversy persists as to the applicability of such guidelines to all cases. Similarly, a lack of consensus exists concerning both the definition of the organ at risk for oral mucositis and the most appropriate endpoint to measure for this critical toxicity. Finally, the correlation between early markers of efficacy such as complete response on PET CT following treatment and subsequent survival needs elucidation for biological subsets of oropharyngeal cancer.
Building a syntactic-semantic interface for asemi-automatically generated TAG for arabic

Syntactic and semantic resources play an important role for various Natural Language Processing (NLP) tasks by providing information about the correct structural representations of the sentences and their meaning. To date, there is not a wide-coverage electronic grammar for the Arabic language. In this context, we present a new approach for building a tree adjoining grammar to represent the syntax and the semantic of modern standard Arabic. This grammar is produced semi-automatically with the XMG (eXtensible MetaGrammar) description language. First the syntax of Arabic is described using the defined Arab-XMG meta-grammar. Then semantic information is added by introducing semantic frame-based dimension into the meta-grammar. This is achieved by exploiting lexical resources such as Arabic VerbNet. Finally, the link between semantic and syntax is established using a syntax-semantic interface that allows the construction of sentence meaning through semantic role labeling. Experiments were performed to check grammar coverage as well as the syntactic-semantic analysis. The results showed that the generated grammar can cover the basic syntactic structures of Arabic sentences and the different phrasal structures with a precision rate of about 92%. Moreover, it confirms the effectiveness of the proposed approach as we were able to parse semantically a set of sentences and build their semantic representations with a precision rate of about 72%.
Fatal oral anticoagulant‐related intracranial hemorrhage: a systematic review and meta‐analysis

Intracranial hemorrhage (ICH) is the most feared complication in patients treated with oral anticoagulants due to non‐valvular atrial fibrillation. Non‐vitamin K oral anticoagulants (NOACs) reduce the risk of ICH compared with vitamin K antagonists (VKAs). We performed a systematic review and meta‐analysis to evaluate the risk of fatal NOAC‐related ICH compared with VKA‐related ICH.
Parallel full-bridge converter for low voltage DC microgrid applications

This paper studies a parallel full-bridge converter with less ripple current and balance load current for low voltage DC microgrid applications. Two full-bridge circuits use same active switches at lagging-leg. Therefore, the zero-voltage switching range of lagging-leg switches is improved. Current doubler rectifiers are adopted to decrease ripple current on output inductor and capacitor. The output voltage regulation and low switching loss are achieved by using phase-shift pulse-width modulation operation. The performance of the studied circuit is verified by experiments with a laboratory prototype rated 1.92 kW.