Miracle-dz/UniFAR-FTUs huggingface dataset:
Método híbrido para categorización de texto basado en aprendizaje y reglas* Hybrid approach for text categorization based on machine learning and rules

This paper discusses a novel method for text categorization that combines a machine learning algorithm able to build a base model with low effort by using a labeled available cor- pus, along with a rule-based expert system in cascade used to filter and rerank the output of the previous classifier. The model can be fine-tuned by adding specific rules for those difficult classes that have not been successfully trained. We describe an implementation based on kNN algorithm and a basic rule language that expresses lists of terms appearing in the text. The sys- tem is trained and evaluated in different scenarios, including the popular Reuters-21578 news corpus for comparison to other approaches, and the IPTC and EUROVOC models. Results show that this approach achieves a precision that is comparable to other top state-of-the-art methods.
A 65 nm CMOS Quad-Band SAW-Less Receiver SoC for GSM/GPRS/EDGE

A quad-band 2.5G receiver is designed to replace the front-end SAW filters with on-chip bandpass filters and to integrate the LNA matching components, as well as the RF baluns. The receiver achieves a typical sensitivity of -110 dBm or better, while saving a considerable amount of BOM. Utilizing an arrangement of four baseband capacitors and MOS switches driven by 4-phase 25% duty-cycle clocks, high-Q BPF's are realized to attenuate the 0 dBm out-of-band blocker. The 65 nm CMOS SAW-less receiver integrated as a part of a 2.5G SoC, draws 55 mA from the battery, and measures an out-of-band 1 dB-compression of greater than +2 dBm. Measured as a stand-alone, as well as the baseband running in call mode in the platform level, the receiver passes the 3GPP specifications with margin.
Human transferrin receptor gene as a marker gene for MR imaging.

PURPOSE To quantitate and characterize the expression of an engineered human transferrin receptor (ETR) as a marker gene by using magnetic resonance (MR) imaging. MATERIALS AND METHODS Rat gliosarcoma 9L cells stably expressing ETR (ETR+) were used, with nontransfected (ETR-) cells serving as controls. A conjugate of transferrin and monocrystalline iron oxide (Tf-MION) nanoparticles was synthesized to probe for the activity of ETR. Accumulation of Tf-MION was examined by using cell internalization in culture and MR (n = 6) and nuclear (n = 4) imaging in a mouse model with ETR+ and ETR- tumors implanted in the opposite flanks. Autoradiographic and histopathologic results were correlated with MR findings. RESULTS Tf-MION was internalized by ETR+ cells at 37 degrees C but not at 4 degrees C. Rhodamine-labeled Tf-MION and fluorescein-labeled antibody to ETR colocalized in small vesicle-like structures in the cytoplasm. Both findings were consistent with accumulation by the receptor-mediated endocytosis mechanism of ETR. Compared with ETR- tumors, ETR+ tumors accumulated more Tf-MION and had higher signal intensity on T1-weighted MR images and lower signal intensity on T2-weighted images. Autoradiographic findings showed a spatial correlation between MR signal intensity and TF-MION accumulation. CONCLUSION ETR+ tumors internalize the MR imaging probe through the action of transferrin receptor in amounts that can be detected with MR imaging.
A novel timing synchronization method for ACO-OFDM-based optical wireless communications

In this paper, new timing synchronization methods for optical wireless systems using asymmetrically clipped optical orthogonal frequency division multiplexing(ACO-OFDM) are described. It is well known that OFDM systems are sensitive to timing synchronization errors. Existing synchronization methods cannot be used directly or do not perform well in ACO-OFDM systems because ACO-OFDM signals are unipolar. Therefore, new synchronization methods using a novel training symbol designed for the characteristics of ACO-OFDM are presented. The sensitivity of the new methods to the phase of the receiver sampling clock is considered and it is shown that if only the lower frequency subcarriers in the training symbol are non zero, the sensitivity can be reduced. Analysis and simulation results show that the new timing synchronization methods are effective in ACO-OFDM systems.
The Time Variation in Risk Appetite and Uncertainty

We formulate a dynamic no-arbitrage asset pricing model for equities and corporate bonds, featuring time variation in both risk aversion and economic uncertainty. The joint dynamics among cash flows, macroeconomic fundamentals, and risk aversion accommodate both heteroskedasticity and non-Gaussianity. The model delivers measures of risk aversion and uncertainty at the daily frequency. We verify that equity variance risk premiums are very informative about risk aversion, whereas credit spreads and corporate bond volatility are highly correlated with economic uncertainty. Our model-implied risk premiums outperform standard instruments for predicting asset excess returns. Risk aversion is substantially correlated with consumer confidence measures and in early 2020 reacted more strongly to new COVID cases than did an uncertainty proxy. This paper was accepted by Haoxiang Zhu, finance.
Tissue-specific N-glycosylation of the ClC-3 chloride channel.

A commercially available polyclonal antibody against a rClC-3/GST fusion protein was used in order to investigate the tissue distribution of the ClC-3 chloride channel protein. The antibody appeared to be specific to rClC-3 since no cross-reaction could be observed with rClC-4 or rClC-5 proteins when overexpressed in Xenopus oocytes. In mouse, mClC-3 was preferentially expressed in the central nervous system, intestine, and kidney. To a lower extent, mClC-3 protein was also detected in liver, lung, skeletal muscle, and heart. Surprisingly, the electrophoretic mobility of mClC-3 differed in the various tissues. After enzymatic digestion of N-linked oligosaccharide residues of membrane proteins from brain, intestine, and kidney, mClC-3 was found to migrate at its calculated molecular mass. This study provides important information regarding the specificity of the used antibody, indicates that ClC-3 is widely expressed in mouse, and that mClC-3 undergoes differential tissue-specific N-glycosylation.
Performance evaluation of feature-based steganalysis in steganography

The objective of this paper is performance testing of Feature-based Steganalysis methods for detection of steganography tools that are used for hiding a secret message in still images. Many of those tools, which can be used publicly, cause statistical changes in original images during embedding process. The features represent those statistically calculated changes, where feature extraction in this paper was applied in spatial domain and also directly in transformation domain of DCT in JPEG files what helps to obtained relevant statistical data. The results of this paper identify the selection of statistical feature vector that is used during training phase of classifier in order to distinguish between cover and stego image. The reliable detection of selected steganography methods were presented in relation to length of feature vector. Moreover, contribution to design of blind steganalysis system was proposed for the purpose of unveiling a secret communication via completely new steganography methods.
Banking Competition, Moral Hazard and Leverage

A large body of literature has blamed moral hazard behaviour by banks, for triggering the recent global financial crisis. Many reasons have been cited for such incentive distortion, e.g. the originate-to-distribute approach, regulatory capital arbitrage or the possibility of systemic bailouts. These motives were stoked by a low interest rate regime, in the wake of free inflow of capital in advanced economies. In contrast, we show that domestic banking competition, per se, reduces monitoring and fuels risky lending booms. Therefore, we claim that the incentive problem is due to banking competition, rather than bailout guarantees or capital account liberalization.
An e.p.r. study of the non-equivalence of the copper sites of caeruloplasmin.

The two Type 1 (blue) copper-binding sites of caeruloplasmin were spectroscopically differentiated by the kinetic analysis of the e.p.r. spectra during the redox cycle. One blue copper, with a hyperfine splitting constant (A parallel) of 6.8 mT, which was rapidly reduced, was not reoxidized by oxygen, whereas it was reoxidized by H2O2. The other blue copper (A parallel = 5.8 mT), which was reduced slowly, was rapidly reoxidized by either oxygen or H2O2. A conformational change of the Type 2 copper was concomitant with the fast reduction of Type 1 copper, whereas its reduction occurred during the slow phase. This sequence of events was reversed in the reoxidation step, that is, the Type 2 copper reappeared rapidly as the species with altered conformation and reverted to the symmetry typical of the native state in the slow phase. The specific reaction of a blue-copper site with the H2O2 can tentatively be related to the established ability of caeruloplasmin to prevent 'oxidative' attack of proteins and lipids.
A study of zero reference effects on electromagnetic transientient measurements of a grounding electrode

This paper presents the effect of zero reference used in measurements of a grounding electrode transient characteristics. Experimental measurements of many cases of Zero reference have been carried out. Different lengths (20 m, 40 m and 60 m) of the zero reference wire in same and right angel directions to the lead wire direction are examined to obtain their effects on transient voltages of the grounding electrode. Zero reference wire is replaced by a cable with different sheath ends grounding in same and right angel directions. Open end and grounded end of zero reference for different cases are tested and studied. The results show that as the length of zero reference wire increases the measured results accuracy increases. Replace zero reference wire by the cable of grounded sheath at both terminals results to the most accurate measurements.
Glucose absorption in small intestinal diseases

Recent developments in the field of diabetes and obesity management have established the central role of the gut in glucose homeostasis; not only is the gut the primary absorptive site, but it also triggers neurohumoral feedback responses that regulate the pre- and post-absorptive phases of glucose metabolism. Structural and/or functional disorders of the intestine have the capacity to enhance (eg: diabetes) or inhibit (eg: short-gut syndrome, critical illness) glucose absorption, with potentially detrimental outcomes. In this review, we first describe the normal physiology of glucose absorption and outline the methods by which it can be quantified. Then we focus on the structural and functional changes in the small intestine associated with obesity, critical illness, short gut syndrome and other malabsorptive states, and particularly Type 2 diabetes, which can impact upon carbohydrate absorption and overall glucose homeostasis.
An Analysis of Profit and Customer Satisfaction in Consumer Finance

This study investigates a set of bank data from a cost/profit perspective. In this specific case, the bank would like to know whether prospective consumers will pay back their credit. The common practice is to calculate the probability that a consumer with certain covariates is to be considered as a potential risk. Our study will go further in the use of the probabilities to maximize the profit. In addition, we will show that the same technique can be used to improve customer satisfaction. The technique should be equally applicable in other consumer markets including auto loans, credit cards, mail catalog orders, home mortgages, and a variety of personal loan products provided by insurance firms, mobile phone companies, and other lending institutions. This case is accessible to readers with an intermediate level of statistics.
Genes and susceptibility to multiple sclerosis

The balance of evidence relating to the aetiology of multiple sclerosis favours an interplay between genetic susceptibility and an environmental trigger. Just as the twin studies show clearly that almost 60% of monozygotic pairs are not concordant for multiple sclerosis (1-3), so also the low concordance rate in dizygotic twins, the rarity of conjugal multiple sclerosis (4), the lack of a birth order effect (9, and the identification of resistant groups living in high prevalence zones, all argue against a purely transmissible factor (6). A simple view would be that, of the candidate genes which have been examined as markers of susceptibility, only the DR15 class 2 major histocompatibility complex (MHC) allele association in northern Europeans holds up to critical analysis. The specifically different associations with DR4 in Japanese (7) and Jordanians (8) have never been confirmed although multiple sclerosis does appear to be DR4 associated in Sardinians (9). There is no evidence that any genetic marker, acting alone or in combination, protects individuals from development of the disease. Reports that the severity of multiple sclerosis correlates with the presence of specific susceptibility alleles, or that the primary progressive form of the disease is associated with a specifically different set of susceptibility markers (1 0), remain unconfirmed.
Replication Factors MCM2 and ORC1 Interact with the Histone Acetyltransferase HBO1*

The minichromosome maintenance (MCM) proteins, together with the origin recognition complex (ORC) proteins and Cdc6, play an essential role in eukaryotic DNA replication through the formation of a pre-replication complex at origins of replication. We used a yeast two-hybrid screen to identify MCM2-interacting proteins. One of the proteins we identified is identical to the ORC1-interacting protein termed HBO1. HBO1 belongs to the MYST family, characterized by a highly conserved C2HC zinc finger and a putative histone acetyltransferase domain. Biochemical studies confirmed the interaction between MCM2 and HBO1 in vitro and in vivo. An N-terminal domain of MCM2 is necessary for binding to HBO1, and a C2HC zinc finger of HBO1 is essential for binding to MCM2. A reverse yeast two-hybrid selection was performed to isolate an allele of MCM2 that is defective for interaction with HBO1; this allele was then used to isolate a suppressor mutant of HBO1 that restores the interaction with the mutant MCM2. This suppressor mutation was located in the HBO1 zinc finger. Taken together, these findings strongly suggest that the interaction between MCM2 and HBO1 is direct and mediated by the C2HC zinc finger of HBO1. The biochemical and genetic interactions of MYST family protein HBO1 with two components of the replication apparatus, MCM2 and ORC1, suggest that HBO1-associated HAT activity may play a direct role in the process of DNA replication.
Observed Characteristics of Suicidal Hangings: An 11‐year Retrospective Review

Many studies have been published regarding suicidal hanging deaths, and most forensic pathologists and coroners are very familiar with such causes of death. Forensic pathologists are challenged over their rulings regarding manner of death in part because the general public has a limited scope of knowledge. One such challenge centers on the question of whether a hanging can be a suicide if the individual is not fully suspended. The authors designed a retrospective study to review suspension in hangings and to analyze other criteria used to help in deciding manner of death. We examined 229 suicidal hanging deaths over an 11‐year period (1997 through early 2009) using the data from two separate jurisdictions in Ohio. In conclusion, we found that the vast majority (83.4%) of people who hanged themselves were found partially suspended. Among other criteria analyzed, only the presence of petechial hemorrhages and acute neck injury was statistically significant.
Accreditation requirements in allied health education: Strengths, weaknesses and missed opportunities

We reviewed the accreditation requirements of professional associations in Allied Health (AH) in Australia to understand the range of accreditation requirements and approaches with a particular focus on requirements around clinical education in AH education. We then identified the strengths in accreditation documents in current approaches and requirements, and areas for improvements where accreditation could better support educational processes and preparation of work ready graduates, as well as missed opportunities for preparing the allied health workforce for future healthcare needs. The findings suggest that the accreditation criteria and standards perform well for the development of students' conceptual and procedural knowledge. However, there are several opportunities for improvement such as preparation of graduates to meet current and future needs of healthcare, focus on biopsychosocial perspectives of health as healthcare models shift from hospital to community-based settings, gaps in interpretation and intentions of accreditation requirements, encouragement of supervision models that are pedagogically sound, increased employer representation on accreditation panels and increased emphasis on development of interprofessional skills. We outline how constraints arising from accreditation requirements limit universities' use of new educational approaches. Arising from this analysis, a summary of considerations for AH accreditation bodies is provided.
Depression is a risk factor for coronary artery disease in men: the precursors study.

BACKGROUND Several studies have found that depression is an independent predictor of poor outcome after the onset of clinical coronary artery disease. There are few data concerning depression as a risk factor for the development of coronary artery disease. OBJECTIVE To determine if clinical depression is an independent risk factor for incident coronary artery disease. PATIENTS AND METHODS The Johns Hopkins Precursors Study is a prospective, observational study of 1190 male medical students who were enrolled between 1948 and 1964 and who continued to be followed up. In medical school and through the follow-up period, information was collected on family history, health behaviors, and clinical depression. Cardiovascular disease end points have been assessed with reviews of annual questionnaires, National Death Index searches, medical records, death certificates, and autopsy reports. RESULTS The cumulative incidence of clinical depression in the medical students at 40 years of follow-up was 12%. Men who developed clinical depression drank more coffee than those who did not but did not differ in terms of baseline blood pressure, serum cholesterol levels, smoking status, physical activity, obesity, or family history of coronary artery disease. In multivariate analysis, the men who reported clinical depression were at significantly greater risk for subsequent coronary heart disease (relative risk [RR], 2.12; 95% confidence interval [CI], 1.24-3.63) and myocardial infarction (RR, 2.12; 95% CI, 1.11-4.06). The increased risk associated with clinical depression was present even for myocardial infarctions occurring 10 years after the onset of the first depressive episode (RR, 2.1; 95% CI, 1.1-4.0). CONCLUSION Clinical depression appears to be an independent risk factor for incident coronary artery disease for several decades after the onset of the clinical depression.
Efficiency of Islamic and conventional banks during financial crisis: Empirical evidence from Malaysia

The global financial crisis that engulfed the world in the mid of 2007 till the end of 2009 slightly affected the Asian countries such as Malaysia has focused attention on the flaws of the conventional banking system. Islamic banks seem much stronger to recover in financial crisis compared to conventional banks because of the inherent nature of Islamic banks, which prohibits the interest payments in all transactions. Thus, this study examines the efficiency level of Islamic and conventional banks during financial crisis particularly in 2007 to 2012. The efficiency of Islamic and conventional banks is measured utilizing Data Envelopment Analysis by adopting the intermediation approach. The data are extracted by Bankscope and Annual Report from 2007 to 2012. The samples consisted of Islamic and conventional banks in Malaysia. The results indicate that pure technical efficiency contributed more to the overall technical efficiency of Islamic banks. In conventional banks, the scale efficiency dominates the overall technical efficiency. In overall, the finding shows that Islamic banks are exhibited higher technical efficiency compared to the conventional banks attributed to the higher pure technical efficiency. Hence, the findings of this study have policy implications, and make a contribution to policy-making by providing empirical evidence on the performance of the Islamic and conventional banks and their efficiency level.
Cutting-Edge Strategies in Massive Transfusion in Patients of Obstetric Hemorrhage

Obstetric hemorrhage is a life-threatening complication which may occur without warning, predictive signs and symptoms, and even in absence of predisposing conditions. It is a major cause of maternal mortality and morbidity almost invariably among all human races. One of the most important strategies in the control of obstetric hemorrhage is hemostatic resuscitation. The speed with which obstetric hemorrhage occurs makes it lifethreatening, but thankfully, it can be successfully managed with blood transfusion protocol based management. Resuscitation of massive hemorrhage has shifted towards the earlier administration of higher doses of fresh frozen plasma (FFP) and reducing serious complications and mortality by limiting the conventional use of crystalloids and colloids. In this article, we explored the leading-edge strategy of use of fibrinogen concentrates, cryoprecipitates, Tranexamic acid and prothrombin complex concentrates, apart from fresh frozen plasma as a promising alternative for obstetric resuscitation and for minimizing the risks and complications of obstetric hemorrhage.
Mechanisms for the Processing of a Frozen Topoisomerase-DNA Conjugate by Human Cell-free Extracts*

The metabolic fate of covalently linked DNA-protein complexes (cross-links) is not clearly understood. Our aim was to investigate the processing of protein-DNA cross-links by cellular enzymes. As an example of a DNA-protein cross-link, we have constructed frozen topoisomerase-DNA conjugates and investigated their processing by human cell-free extracts. A suicide DNA substrate was constructed that upon reaction with vaccinia type I topoisomerase yielded a highly stable covalent DNA-protein cross-link. When this conjugate was treated with human nuclear or whole cell extracts, two sites of DNA breakpoints were detected: one set of double-stranded breaks occurred close to the 3′ side of the topoisomerase (topo) conjugation site, and there was another set of nicks about 30 nucleotides 3′ to the topo site. The double-stranded breaks were not made by extracts from xeroderma pigmentosum group A mutant cells, suggesting that the xeroderma pigmentosum group A damage recognition protein may be required for the occurrence of DNA breakage. In addition to these DNA breakage reactions, there was an activity that resulted in the delinking of the frozen topoisomerase (or proteolytic fragments thereof) from the DNA substrate, which was followed by a ligation step that restored the continuity of the broken DNA strand at the erstwhile topo attachment site. We suggest that frozen topoisomerase-DNA conjugates (and perhaps other types of covalent DNA-protein complexes) are processed by multiple pathways that may involve the cleavage of the DNA in the covalent protein-DNA complex and/or enzymatic delinking followed by ligation of the broken DNA ends. These processes may represent the “repair” of DNA-protein cross-links.