Miracle-dz/UniFAR-FTUs huggingface dataset:
OPTIMIZACION GLOBAL DE COHERENCIA EN LA DESAMBIGUACION DEL SENTIDO DE LAS PALABRAS

II RESUMEN . III CONTENIDO GENERAL DE LA TESIS. IV ÍNDICE DETALLADO DE LA TESIS . V LISTA DE FIGURAS. VIII LISTA DE TABLAS. IX GLOSARIO. XI CAPÍTULO 1. INTRODUCCIÓN . 2 CAPÍTULO 2. EL LENGUAJE NATURAL Y EL PROBLEMA DE LA AMBIGÜEDAD SEMÁNTICA. 9 CAPÍTULO 3. MÉTODOS DE OPTIMIZACIÓN GLOBAL . 34 CAPÍTULO 4. RESULTADOS EXPERIMENTALES. 45 CAPÍTULO 5. CONCLUSIONES Y TRABAJO FUTURO. 61 REFERENCIAS. 67 ÍNDICE DE TÉRMINOS. 73 ANEXOS . 75
Probing the O-Glycoproteome of Gastric Cancer Cell Lines for Biomarker Discovery*

Circulating O-glycoproteins shed from cancer cells represent important serum biomarkers for diagnostic and prognostic purposes. We have recently shown that selective detection of cancer-associated aberrant glycoforms of circulating O-glycoprotein biomarkers can increase specificity of cancer biomarker assays. However, the current knowledge of secreted and circulating O-glycoproteins is limited. Here, we used the COSMC KO “SimpleCell” (SC) strategy to characterize the O-glycoproteome of two gastric cancer SimpleCell lines (AGS, MKN45) as well as a gastric cell line (KATO III) which naturally expresses at least partially truncated O-glycans. Overall, we identified 499 O-glycoproteins and 1236 O-glycosites in gastric cancer SimpleCells, and a total 47 O-glycoproteins and 73 O-glycosites in the KATO III cell line. We next modified the glycoproteomic strategy to apply it to pools of sera from gastric cancer and healthy individuals to identify circulating O-glycoproteins with the STn glycoform. We identified 37 O-glycoproteins in the pool of cancer sera, and only nine of these were also found in sera from healthy individuals. Two identified candidate O-glycoprotein biomarkers (CD44 and GalNAc-T5) circulating with the STn glycoform were further validated as being expressed in gastric cancer tissue. A proximity ligation assay was used to show that CD44 was expressed with the STn glycoform in gastric cancer tissues. The study provides a discovery strategy for aberrantly glycosylated O-glycoproteins and a set of O-glycoprotein candidates with biomarker potential in gastric cancer.
Classification of mutations at the HLA‐A locus by use of the polymerase chain reaction

We investigated whether the polymerase chain reaction (PCR) could be used to determine the mechanism of mutation in lymphocyte clones mutated at the HLA‐A locus. Three polymorphisms, at Factor XIIIA, D6S109, and intron 3 of the HLA‐A gene, were used to study a series of clones previously characterised by Southern blotting (SB) at multiple loci on chromosome 6. For detection of loss of heterozygosity, the results of PCR and SB were concordant in 140 of 141 clones when polymorphism in the Factor XIIIA region was studied and in 144 of 145 clones when polymorphism in the HLA‐A gene was studied. For classification of the mechanism of mutation, PCR and SB gave the same result in 88 of 92 clones (96%) when a combination of the HLA‐A and Factor XIIIA polymorphisms was used and in 46 of 47 clones (98%) when a combination of the HLA‐A and D6S109 polymorphisms was used. The results indicate that PCR provides a simple and reliable method for categorising mutations at the HLA‐A locus as arising from mitotic recombination, deletion, or from presumptive minor changes within the gene. Rare events such as gene conversion, nondisjunction, or large deletions extending to the telomere will be misclassified. However, such events are rare for mutations at this locus. © 1993 Wiley‐Liss, Inc.
Age-related decline in serum parathyroid hormone in maintenance hemodialysis patients is independent of inflammation and dietary nutrient intake.

BACKGROUND There is a direct relationship between age and serum parathyroid hormone (iPTH) in the normal population, but several studies suggest this relationship is reversed in maintenance hemodialysis (MHD) patients. The pathophysiologic basis of this age-related decline in serum iPTH levels remains unclear, although others have proposed that it is related to low dietary phosphorus intakes. METHODS We conducted a prospective, cross-sectional evaluation of the relationship between age and serum iPTH levels and factors affecting this relationship. All participating subjects were asked to complete a 3-day food diary. The charts were reviewed to obtain routinely measured laboratory values over the preceding 3 months, and serum was collected to measure markers of systemic inflammation. RESULTS Ninety-two MHD patients (47 men; age, 51.3+/-14.9 [standard deviation] years; median dialysis vintage, 25.8 months) were studied. Age was inversely correlated with both serum phosphorus and iPTH; these relationships remained significant even when the data were adjusted for diabetic status, dialysis vintage, and dietary nutrient intake. However, there were no associations of age, serum phosphorus, or iPTH with dietary intakes of protein, calories, phosphorus, or calcium either on univariate or multivariate analyses. Markers of systemic inflammation (serum C-reactive protein, and alpha1 acid glycoprotein) did not correlate with age, serum phosphorus, and iPTH or dietary nutrient intake. On the other hand, serum albumin, which may reflect long-term effects of inflammation, did correlate inversely with age and positively with serum phosphorus. CONCLUSIONS Our cross-sectional study confirms that there are age-related lower levels of both serum phosphorus and iPTH in MHD patients. The mechanisms regarding the inverse relationship between serum phosphorus and age are unclear, but may not be caused by low phosphorus intake or systemic inflammation. In elderly MHD patients, the reduced responsiveness of parathyroid glands may be related to age-dependent accumulation of uremic toxins.
Análogos de insulina: ¿qué son, por qué, y cómo usarlos en la práctica médica?

En la era preinsulínica la única forma de controlar la diabetes fue con dietas bajas en carbohidratos y alta en grasas y proteínas . Esto permitía que los pacientes, en vez de fallecer al poco tiempo del diagnóstico, vivieran meses y excepcionalmente más de un año. En 1921, un grupo canadiense de investigadores (F. Banting; Ch. Best; JJR Macleod), purificaron la insulina y probaron que la diabetes es una enfermedad por deficiencia de insulina. Un año después, el joven L. Thompson fue el primer paciente en recibir insulina en un hospital de Toronto, mejorando drásResumen
Thrombopoietic Cytokines in Patients with Iron Deficiency Anemia with or without Thrombocytosis

Iron deficiency anemia is a cause of reactive thrombocytosis. A moderate increase in platelet numbers is common but sometimes counts may exceed 1,000 × 109/l. The mechanisms causing reactive thrombocytosis are unclear. In this study, we evaluated 15 women with iron deficiency anemia and thrombocytosis (platelets >450 × 109/l) and 16 women with iron deficiency anemia with normal platelet counts. Serum samples were taken before oral iron replacement therapy, after 1 and 3 months and at the end of replacement therapy. Thrombopoietin, erythropoietin (EPO), leukemia inhibitory factor, interleukin-6 and interleukin-11 levels were assayed. There was no change in the levels of thrombopoietic cytokines except for EPO. The correlation between high EPO levels and high platelet counts may suggest that EPO increases platelet counts, but the same EPO level changes can also be demonstrated in women with iron deficiency anemia but normal initial platelet counts. The fact that the levels of other cytokines remained unchanged during treatment suggests that either these cytokines have no effect on reactive thrombocytosis or the change in platelet counts in our patients is in a narrow range and is thus not affected by the cytokine levels.
Semántica oculta en modelos de requisitos

La Ingenieria de Requisitos (IR) es un area dentro de la Ingenieria de Software que tiene por objetivo mejorar la forma en que se comprenden y definen sistemas de software complejos. Los modelos construidos en el proceso de la Ingenieria de Requisitos han sido concebidos procurando maximizar su expresividad en relacion con su proposito. Este proyecto se enmarca en una estrategia de la IR basada en dos modelos principales: el LEL (Lexico Extendido del Lenguaje) y los Escenarios. Estos modelos constituyen la base de una estrategia para obtener una especificacion de requisitos de software. Sin embargo, estos modelos parecen contener mas informacion que la que puede obtenerse en una primera lectura. En este articulo se propone, justamente, realizar nuevas lecturas de estos modelos para extraer esa informacion adicional. En particular, se propone obtener informacion sobre la estructura semantica de glosarios del proceso del negocio, a partir de su visualizacion por medio de grafos. Palabras clave: Ingenieria de Requisitos, Glosarios, Trazado de Grafos, Metodos Dirigidos por Fuerzas.
Hyperglycemia in acute coronary syndromes: from mechanisms to prognostic implications

Hyperglycemia is a frequent condition in patients with acute coronary syndromes (ACS). Hyperglycemia during ACS is caused by an inflammatory and adrenergic response to ischemic stress, when catecholamines are released and glycogenolysis induced. Although the involved pathophysiological mechanisms have not yet been fully elucidated, it is believed that hyperglycemia is associated with an increase in free fat acids (which induce cardiac arrhythmias), insulin resistance, chemical inactivation of nitric oxide and the production of oxygen reactive species (with consequent microvascular and endothelial dysfunction), a prothrombotic state, and vascular inflammation. It is also related to myocardial metabolic disorders, leading to thrombosis, extension of the damaged area, reduced collateral circulation, and ischemic preconditioning. In the last few years, several observational studies demonstrated that hyperglycemia in ACS is a powerful predictor of survival, increasing the risk of immediate and long-term complications in patients both with and without previously known diabetes mellitus. Glucose management strategies in ACS may improve outcomes in patients with hyperglycemia, perhaps by reducing inflammatory and clotting mediators, by improving endothelial function and fibrinolysis and by reducing infarct size. Recent clinical trials of insulin in ACS have resulted in varying levels of benefit, but the clinical benefit of an aggressive treatment with insulin is yet unproved.
A novel method for improving the fault tolerance of transformerless cascade PWM STATCOM

A novel control method is presented for improving the reliability of transformerless cascade STATCOMs operating under various faults. A modified H bridge circuit is proposed, and it could be totally bypassed under various faults while the STATCOM keep working. During the fault transient, by controlling the phase of a STATCOMpsilas output voltage, the DC capacitors could be charged or discharged to maintain the STATCOMpsilas capability of outputting reactive power. The simulation results about the performances of the proposed method and circuit are given.
Connected model for opportunistic sensor network based on Katz centrality

Connectivity is an important indicator of network performance. But the opportunistic sensor networks (OSNs) have temporal evolution characteristics, which are hard to modelled with traditional graphs. After analyzing the characteristics of OSNs, this paper constructs OSNs connectivity model based on time graph theory. The overall connectivity degree of the network is defined, and is used to estimate actual network connectivity. We also propose a computing method that uses the adjacency matrix of each snapshot. The simulation results show that network connectivity degree can reflect the overall connectivity of OSNs, which provide a basis for improving the OSNs performance.
DEVELOPMENT OF AN FPGA BASED IMAGE PROCESSING INTELLECTUAL PROPERTY CORE SREEJITH M DEPARTMENT OF ELECTRICAL ENGINEERING

Traditional image processing algorithms are sequential in nature. When these algorithms are implemented in a real-time system, the response time will be high. In an embedded platform, such algorithms consumes more power because of more number of clock cycles required to execute the algorithm. With the advent of Field Programmable Gate Arrays (FPGA), massively parallel architectures can be developed to accelerate the execution speed of several image processing algorithms. In this work , such a parallel architecture is proposed to accelerate the SOBEL edge detection algorithm. The architecture is simulated in Modelsim 10.2C student edition platform. To simulate this architecture, a model of video acquisition system is developed. This model will convert the incoming frames to digital composite video signals which can be processed by the edge detection architecture. An external software developed in Matlab will convert the frames in to hexadecimal format, and will feed the video acquisition model. The output of the edge detection processor will be a digital composite signal. A display module will convert the digital composite video signals in to hexadecimal format. Then with the help of an external Matlab program, the original image will be reconstructed. The result shown compares the sequential and parallel environments, and shows significant improvements in FPGA based implementations. The Modelsim simulation of SOBEL based edge detection algorithm for a 256 × 256 frame, gave a result in 0.019 seconds for a clock speed of 10MHz, where as a Matlab based simulation took 0.22 seconds to finish this operation, which is a significant acceleration. Moreover, a new software simulation platform was developed as a part of this project, which will let the developer to give input as image and the output will be reproduced in the same format, while all the background processing will be carried out in VHDL. The simulation results are shown in this simulation platform. This software can be used as a simulation platform for any FPGA based image processing operations. This work has wider scope and applications. FPGA based edge detection system can serve as the basic step for implementations of complex computer vision algorithms. The implementation of fast face detection in a digital camera, fast object tracking, policing and interactive surveillance, and finally the applications like object tracking and chasing are some of the areas where this work can be made use of.
Fonctions noyaux pour molécules et leur application au criblage virtuel par machines à vecteurs de support

La recherche therapeutique a de plus en plus recours a des techniques de modelisation, dites de criblage virtuel, visant a correler la structure d'une molecule avec ses proprietes biologiques. En particulier, l'utilisation de modeles predictifs quantifiant la toxicite d'une molecule ou son activite vis a vis d'une cible therapeutique, permet de reduire de maniere considerable le temps et les couts necessaires a la mise au point de nouveaux medicaments. Nous nous proposons d'aborder ce probleme dans le cadre des methodes a noyaux, qui permettent de construire de tels modeles de maniere efficace des lors que l'on dispose d'une fonction noyau mesurant la similarite des objets que l'on considere. Plus particulierement, l'objet de cette these est de definir de telles fonctions noyaux entre structures bi- et tri-dimensionnelles de molecules. D'un point de vue methodologique, ce probleme se traduit respectivement comme celui de comparer des graphes representant les liaisons covalentes des molecules, ou des ensembles d'atomes dans l'espace. Plusieurs approches sont envisagees sur la base de l'extraction et la comparaison de divers motifs structuraux qui permettent d'encoder les groupes fonctionnels des molecules a differents niveaux de resolution. Les validations experimentales suggerent que cette methodologie est une alternative prometteuse aux approches classiques en criblage virtuel.
The cytokine response to bacille Calmette Guérin vaccination in South India.

SETTING Evaluation of immune response after BCG vaccination in a population from South India where BCG vaccination was a failure. OBJECTIVE To study the cell-mediated immune responses (CMI) in vitro by assessing skin test conversion, lymphocyte proliferation and cytokine patterns before and after BCG vaccination in 20 Mantoux negative subjects, and to compare this with that of 20 naturally Mantoux positive subjects. DESIGN In vitro lymphocyte proliferation and cytokine responses to various mycobacterial antigens were studied in 12 subjects from each group. The cytokines interferon gamma (IFN-gamma), interleukin (IL)-4 and IL-10 were measured by both reverse transcriptase polymerase chain reaction (RT-PCR) and enzyme linked immunosorbent assay (ELISA). RESULTS All of those who were initially Mantoux negative but one subject converted to positivity following vaccination, confirming that BCG vaccination does cause skin test conversion. However, in vitro proliferative responses to phytohaemagglutinin (PHA), purified protein derivative (PPD) and Mycobacterium tuberculosis remained largely unaltered by vaccination. The production of IFN-gamma was significantly higher in PPD-positive individuals compared to the PPD-negative group, and BCG vaccination of the latter did not change the levels of IFN-gamma, IL-4 or IL-10. CONCLUSIONS The finding that PPD-negative individuals did not produce IFN-gamma even following vaccination and skin test conversion suggests that BCG had little effect in driving the immune response towards a protective Th1 type.
Three cases of acute methyl bromide poisoning in a seedling farm family.

We encountered three patients (Patient I: 39-year-old man, Patient II: 34-year-old woman, and Patient III: 5-year-old girl) with acute methyl bromide poisoning, which had occurred as a result of exposure to the gas that leaked from methyl bromide cans stored in a warehouse of a seedling farm. Since all three patients exhibited almost the same initial symptoms, i.e., severe vomiting, tonic convulsions and clouding of consciousness, botulism was suspected at first. However, subsequent inquiry revealed that 27 cans of methyl bromide had been stored in the building that the patients lived in, and that the cans had been damaged a few days before the onset of the patients' illness by a thrashing machine that was being moved by them to another location. Inspection revealed that all the cans of methyl bromide had passed the expiry date and were corroded. Even though none of the cans had been used, three cans with a capacity of 750 g were found to be empty. Plasma bromide ion concentrations were determined to be high (72.9 microg/ml, 67.8 microg/ml and 91.5 microg/ml; normal level, < 5 microg/ml), and acute methyl bromide poisoning was diagnosed 8 days after admission of the patients to the hospital. Hemodialysis (peritoneal lavage in the case of the child) was performed immediately, after which the plasma bromide ion concentrations returned to normal and the general condition of the patients gradually improved.
MicroRNA in hepatic fibrosis and cirrhosis 1419 causing blood flow changes and the potential development of liver failure

Hepatic fibrosis is caused by an imbalance between production and dissolution of extracellular matrix after chronic and inflmmatory injury, when hepatic stellate cells are stimulated to proliferate and secret extracellular matrix. The most common causes of liver fibrosis are chronic viral hepatitis B and C. Cirrhosis is the most advanced stage of fibrosis, which usually develop into hepatocellular carcinoma (HCC). microRNAs participate the pathogenesis of hepatic fibrosis and cirrhosis or even the onset of HCC. In this review, we will summarize the role of miRNA in the pathogenesis of viral hepatitis fibrosis, non-alcoholic steatohepatitis fibrosis, primary biliary cirrhosis and HCC onset, especially in the regulation of stellate cells. 2. INTRODUCTION
Technology Integration In Nursing Practice

: With technology development and increasing advances in technology, nurses moving from the bedside to administration have found that information systems and technology are now a standard part of the daily nursing workflow. Nursing Informatics (NI) divided into basic computer competence and advanced nursing informatics competence. The purpose of this paper is to provide and highlight the information about Nursing Informatics (NI) and the effect on patients care and outcome. Health professionals should use informatics to communicate, manage knowledge, mitigate error, and support decision making using information technology. Organizations and, authors recommended NI for analyzing, formalizing and modeling the collection, management, processing and analysis of data to build information and knowledge that will inform decisions regarding patient care, which included more than one view.
Panax ginsengRhodiola rosea and Schisandra chinensis

Panax ginseng (Ginseng), Rhodiola rosea (Hong Jing Tian) and Schisandra chinensis (Wu Wei Zi) are well-known herbs in traditional Chinese medicine (TCM). Recently, there have been a number of studies on these three herbs. This review discusses their active components and major pharmacological effects. For P. ginseng, it has been shown to have an anti-inflammatory activity, affects pulmonary function and erectile dysfunction, improves cognition in patients with Alzheimer's disease and promotes sexual arousal in menopausal women as well as prevents cancer. For R. rosea, its effectiveness in alleviating depression and reducing fatigue is summarized in this review. Additionally, anti-cancer and other clinical effects of S. chinensis are also discussed. These three herbs are considered as adaptogens as they bear multiple functions and their effects were found to be very different in patients depending on the circumstances (age, gender, environment, diet, season, etc.). Thus, in most cases, the art of the TCM practitioner is to prescribe these herbs after a complete evaluation of overall heath status of the patients.