Miracle-dz/UniFAR-FTUs huggingface dataset:
Leveraging Population Health Expertise to Enhance Community Benefit

As the Internal Revenue Service strengthens the public health focus of community benefit regulations, and many states do the same with their tax codes, hospitals are being asked to look beyond patients in their delivery system to understand and address the needs of geographic areas. With the opportunities this affords come challenges to be addressed. The regulations' focus on population health is not limited to a defined clinical population—and the resulting emphasis on upstream determinants of health and community engagement is unfamiliar territory for many healthcare systems. At the same time, for many community residents and community-based organizations, large medical institutions can feel complicated to engage with or unwelcoming. And for neighborhoods that have experienced chronic underinvestment in upstream determinants of health—such as social services, housing and education—funds made available by hospitals through their community health improvement activities may seem insufficient and unreliable. Despite these regulatory requirements, many hospitals, focused as they are on managing patients in their delivery system, have not yet invested significantly in community health improvement. Moreover, although there are important exceptions, community health improvement projects have often lacked a strong evidence base, and true health system-community collaborations are relatively uncommon. This article describes how a large academic medical center tapped into the expertise of its population health research faculty to partner with local community-based organizations to oversee the community health needs assessment and to design, implement and evaluate a set of geographically based community-engaged health improvement projects. The resulting program offers a paradigm for health system investment in area-wide population health improvement.
Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer

Nevirapine has been proved to be effective in inducing re-differentiation and suppressing tumor growth in several tumor cells. This study aims to investigate the therapeutic potential of nevirapine in dedifferentiated thyroid cancer (DeTC), which refractory to radioiodine treatment and the underlying mechanisms. The results indicated that nevirapine significantly inhibited the proliferation and increased the expressions of thyroid differentiation-related genes, thyroid stimulating hormone receptor (TSHR), sodium/iodide symporter (NIS), thyroid peroxidase (TPO), and transcriptional factor paired box 8 (PAX8) in dedifferentiated thyroid cancer cells (WRO 82-1 and dFTC-133). Furthermore, nevirapine also enhanced radioiodide uptake significantly both in vitro and in vivo, and inhibited the growth of xenograft tumors. Nevirapine might improve radioiodine sensitivity via the activation of TSHR/cAMP/CREB/PAX8 signaling pathway. This study demonstrates that nevirapine could be potentially used to improve radioiodine therapeutic efficacy in dedifferentiated thyroid cancer patients.
Multifunctional Copper-Containing Mesoporous Glass Nanoparticles as Antibacterial and Proangiogenic Agents for Chronic Wounds

The physiological wound healing process involves a cascade of events which could be affected by several factors resulting in chronic, non-healing wounds. The latter represent a great burden especially when bacterial biofilms are formed. The rise in antibiotic resistance amongst infectious microorganisms leads to the need of novel approaches to treat this clinical issue. In this context, the use of advanced biomaterials, which can enhance the physiological expression and secretion of the growth factors involved in the wound healing process, is gaining increasing attention as a robust and appealing alternative approach. Among them, mesoporous glasses are of particular interest due to their excellent textural properties and to the possibility of incorporating and releasing specific therapeutic species, such as metallic ions. One of the most attractive therapeutic ions is copper thanks to its proangiogenic and antibacterial effects. In this contribution, copper containing mesoporous glass nanoparticles were proposed as a multifunctional device to treat chronic wounds. The developed nanoparticles evidenced a very high specific surface area (740 m2/g), uniform pores of 4 nm and an almost total release of the therapeutic ion within 72 h of soaking. The produced nanoparticles were biocompatible and, when tested against Gram positive and Gram negative bacterial species, demonstrated antibacterial activity against both planktonic and biofilm bacteria in 2D cell monolayers, and in a 3D human model of infected skin. Their proangiogenic effect was tested with both the aortic ring and the chick chorioallantoic membrane assays and an increase in endothelial cell outgrowth at a concentration range between 30 and 300 ng/mL was shown. Overall, in this study biocompatible, multifunctional Cu-containing mesoporous glass nanoparticles were successfully produced and demonstrated to exert both antibacterial and proangiogenic effects.
Treatment Of Severe Crowding And a Narrow Maxilla With Surgically Assisted Rapid Maxillary Expansion (SARME) : A Case Report

Surgically assisted rapid maxillary expansion (SARME) is a treatment modality used for the management of transverse maxillary hypoplasia, especially in adolescents and young adults (1). Many factors such as congenital, developmental, iatrogenic and traumatic factors are responsible in the etiology. The cause of maxillary constrictions could be; oral breathing, infancy type swallowing and tongue thrust. Radiographic and clinical examination should be performed for the exact diagnosis of this type of deformity. The clinical findings are unilateral or bilateral crossbite, narrow palatal vault, rotated, crowded and palatally or buccally displaced teeth and a narrow and V shaped maxillary arch form (2-4). The cause of crossbite in adult patients is either skeletal or dental. Dental crossbites are usually treated by only orthodontic management. However, crossbites of more than one teeth are suggested to be the result of skeletal problems (5). SARME can be defined as the use of orthodontic expansion appliance with maxillary surgery. It is used especially in patients who has completed their skeletal maturation (6). The aim of this case report was to evaluate dentofacial effects of SARME treatment protocol.
A descriptive survey of renal unit practitioners' knowledge, attitude and practice relative to use and effects of unfractionated heparin in selected adult chronic haemodialysis centres in the Cape Town metropole

vi CONCEPTUAL DEFINITIONS . viii ABBREVIATIONS . xi TABLE OF CONTENTS . xiii List of Tables and Figures . xviii Tables . xviii Figures . xix CHAPTER 1: INTRODUCTION . 1 1.
A BI-objective Model for SVM With an Interactive Procedure to Identify the Best Compromise Solution

A support vector machine (SVM) learns the decision surface from two different classes of the input points, there are misclassifications in some of the input points in several applications. In this paper a bi-objective quadratic programming model is utilized and different feature quality measures are optimized simultaneously using the weighting method for solving our bi-objective quadratic programming problem. An important contribution will be added for the proposed bi-objective quadratic programming model by getting different efficient support vectors due to changing the weighting values. The numerical examples, give evidence of the effectiveness of the weighting parameters on reducing the misclassification between two classes of the input points. An interactive procedure will be added to identify the best compromise solution from the generated efficient solutions.
DAMPING TECHNIQUES OF HARMONIC RESONANCES

Harmonic resonances may damage equipments and interrupt electric power customers' services. Shutdowns may affect seriously harmonic resonant frequencies and may initiate new resonances in distribution power systems. This paper proposes various techniques for damping harmonic resonances in power systems [1-4]. A series reactor should be connected in series with the shunt power factor correction capacitor, damping resistance across inductor terminals of LC passive filter, increasing the short circuit system power, derating the harmonic generating equipment, and by using hybrid active filters. The hybrid active filters consist of active filter connected in shunt with passive filter. The active filter is characterized by detecting the harmonic current flowing into the passive filter. It is controlled in such a way as to behave as resistor by adjusting certain gain. It is proved that this significantly improves damping of the harmonic resonances, compared with the passive filter when used alone [5-7].
Particle therapy in Europe

Particle therapy using protons or heavier ions is currently the most advanced form of radiotherapy and offers new opportunities for improving cancer care and research. Ions deposit the dose with a sharp maximum – the Bragg peak – and normal tissue receives a much lower dose than what is delivered by X‐ray therapy. Particle therapy has also biological advantages due to the high linear energy transfer of the charged particles around the Bragg peak. The introduction of particle therapy has been slow in Europe, but within the last decade, more than 20 clinical facilities have opened and facilitated access to this frontline therapy. In this review article, the basic concepts of particle therapy are reviewed along with a presentation of the current clinical indications, the European clinical research, and the established networks.
Adult survivors of childhood cancer and unemployment

A range of late effects is associated with the survival of childhood cancer, including problems with employment. The purpose of this metaanalysis was to assess the risk of unemployment of adult survivors of childhood cancer compared with healthy controls and to explore prognostic factors. A literature search of studies published between 1966 and January 2006 was conducted using the databases of MedLine, CINAHL, EMBASE, ClinPSYCH, PsycINFO, and OSHROM. The authors synthesized data using a random effects model. A total of 34 articles was found, in which 40 original empirical studies were reported, 24 of which were controlled studies. Survivors of childhood cancer were nearly twice as likely to be unemployed than healthy controls (odds ratio [OR] 1.85, 95% confidence interval [95% CI], 1.27‐2.69). Survivors of central nervous system (CNS) and brain tumors were nearly 5 times more likely to be unemployed (OR 4.74, 95% CI, 1.21‐18.65), whereas the risks for survivors of blood or bone cancers were elevated but not found to be statistically significant (OR 1.42, 95% CI, 0.79‐2.55; OR 1.97, 95% CI, 0.88‐4.40, respectively). No increased risk was found for survivors of other or mixed diagnoses (OR 0.97, 95% CI, 0.27‐3.53). Furthermore, survivors in the U.S. had an overall 3‐fold risk (OR 3.24, 95% CI, 2.16‐4.86) of becoming unemployed, whereas no such risk was found for European survivors (OR 1.00, 95% CI, 0.58‐1.70). Apart from type of diagnosis and country, predictors of unemployment were younger age, lower education or intelligence quotient, female gender, motor impairment or epilepsy, and radiotherapy. Adult survivors of childhood cancer are at risk of unemployment, especially the subgroup of survivors of CNS and brain tumors. Interventions to enhance participation in work life should be developed and evaluated. Cancer 2006. © 2006 American Cancer Society.
The metastable states of proteins

The intriguing process of protein folding comprises discrete steps that stabilize the protein molecules in different conformations. The metastable state of protein is represented by specific conformational characteristics, which place the protein in a local free energy minimum state of the energy landscape. The native‐to‐metastable structural transitions are governed by transient or long‐lived thermodynamic and kinetic fluctuations of the intrinsic interactions of the protein molecules. Depiction of the structural and functional properties of metastable proteins is not only required to understand the complexity of folding patterns but also to comprehend the mechanisms of anomalous aggregation of different proteins. In this article, we review the properties of metastable proteins in context of their stability and capability of undergoing atypical aggregation in physiological conditions.
Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer.

BACKGROUND Recent guidelines recommend consideration of the use of oral edoxaban or rivaroxaban for the treatment of venous thromboembolism in patients with cancer. However, the benefit of these oral agents is limited by the increased risk of bleeding associated with their use. METHODS This was a multinational, randomized, investigator-initiated, open-label, noninferiority trial with blinded central outcome adjudication. We randomly assigned consecutive patients with cancer who had symptomatic or incidental acute proximal deep-vein thrombosis or pulmonary embolism to receive oral apixaban (at a dose of 10 mg twice daily for the first 7 days, followed by 5 mg twice daily) or subcutaneous dalteparin (at a dose of 200 IU per kilogram of body weight once daily for the first month, followed by 150 IU per kilogram once daily). The treatments were administered for 6 months. The primary outcome was objectively confirmed recurrent venous thromboembolism during the trial period. The principal safety outcome was major bleeding. RESULTS Recurrent venous thromboembolism occurred in 32 of 576 patients (5.6%) in the apixaban group and in 46 of 579 patients (7.9%) in the dalteparin group (hazard ratio, 0.63; 95% confidence interval [CI], 0.37 to 1.07; P<0.001 for noninferiority). Major bleeding occurred in 22 patients (3.8%) in the apixaban group and in 23 patients (4.0%) in the dalteparin group (hazard ratio, 0.82; 95% CI, 0.40 to 1.69; P = 0.60). CONCLUSIONS Oral apixaban was noninferior to subcutaneous dalteparin for the treatment of cancer-associated venous thromboembolism without an increased risk of major bleeding. (Funded by the Bristol-Myers Squibb-Pfizer Alliance; Caravaggio ClinicalTrials.gov number, NCT03045406.).
Chronic wasting disease undermines efforts to control the spread of brucellosis in the Greater Yellowstone Ecosystem.

Wildlife diseases pose a substantial threat to the provisioning of ecosystem services. We use a novel modeling approach to study the potential loss of these services through the imminent introduction of chronic wasting disease (CWD) to elk populations in the Greater Yellowstone Ecosystem (GYE). A specific concern is that concentrating elk at feedgrounds may exacerbate the spread of CWD, whereas eliminating feedgrounds may increase the number of elk on private ranchlands and the transmission of a second disease, brucellosis, from elk to cattle. To evaluate the consequences of management strategies given the threat of two concurrent wildlife diseases, we develop a spatio-temporal bioeconomic model. GPS data from elk and landscape attributes are used to predict migratory behavior and population densities with and without supplementary feeding. We use a 4,800 km2 area around Pinedale, WY containing four existing feedgrounds as a case study. For this area, we simulate welfare estimates under a variety of management strategies. Our results indicate that continuing to feed elk could result in substantial welfare losses for the case-study region. Therefore, to maximize the present value of economic net benefits generated by the local elk population upon CWD's arrival in the region, wildlife managers may wish to consider discontinuing elk feedgrounds while simultaneously developing new methods to mitigate the financial impact to ranchers of possible brucellosis transmission to livestock. More generally, our methods can be used to weigh the costs and benefits of human-wildlife interactions in the presence of multiple disease risks.
Facts about Cancer

• This year about 589,430 Americans are expected to die of cancer, almost 1,620 people a day. • Cancer is the second most common cause of death in the United States. • In the United States, nearly 1 in 4 deaths are from cancer. • Men have slightly less than a 1 in 2 lifetime risk of developing cancer; for women, the lifetime risk is a little more than 1 in 3. • This year about 1,658,370 new cancer cases are expected to be diagnosed nationwide; 11,050 new cases are expected in Utah. • The Agency for Healthcare Research and Quality (AHRQ) estimates that the direct medical costs (total of all health care expenditures) for cancer in the US in 2011 were $88.7 billion. • Lung cancer is the leading cause of cancer death in both men and women. • Tobacco-related diseases are the most preventable cause of death worldwide, responsible for the deaths of approximately half of all long-term tobacco users. • The greatest risk factor for cancer is age, with about 78 percent of all cancers diagnosed at age 55 and older. • Although uncommon, cancer is the second leading cause of death in children. • The World Cancer Research Fund estimates that up to one-third of the cancer cases in the U.S. are related to overweight or obesity, physical inactivity, and/or poor nutrition.
Fulminant type 1 diabetes: A comprehensive review of an autoimmune condition

Fulminant type 1 diabetes (FT1D) is a subset of type 1 diabetes characterized by extremely rapid pancreatic β‐cell destruction with aggressive progression of hyperglycaemia and ketoacidosis. It was initially classified as idiopathic type 1 diabetes due to the absence of autoimmune markers. However, subsequent studies provide evidences supporting the involvement of autoimmunity in rapid β‐cell loss in FT1D pathogenesis, which are crucial for FT1D being an autoimmune disease. This article highlights the role of immunological aspects in FT1D according to the autoimmune‐associated genetic background, viral infection, innate immunity, adaptive immunity, and pancreas histology.
Preliminary Discussion of the Distribution Characteristics of Venomous Snake Species in One City and Four Counties in Guangxi and the Diagnosis and Treatment Strategies of Snakebite based on the Classified Evidence Method

Luo et al. Int J Crit Care Emerg Med 2020, 6:099 • Page 1 of 9 • Citation: Luo Y, li Z, Zhang J, Li Q, Zhai C, et al. (2020) Preliminary Discussion of the Distribution Characteristics of Venomous Snake Species in One City and Four Counties in Guangxi and the Diagnosis and Treatment Strategies of Snakebite based on the Classified Evidence Method. Int J Crit Care Emerg Med 6:099. doi.org/10.23937/2474-3674/1510099 Accepted: March 09, 2020: Published: March 11, 2020 Copyright: © 2020 Luo Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Preliminary Discussion of the Distribution Characteristics of Venomous Snake Species in One City and Four Counties in Guangxi and the Diagnosis and Treatment Strategies of Snakebite based on the Classified Evidence Method
Anti-virus Software: The Challenge of Being Prepared for Tomorrows MalWare Today

Defending ourselves against MalWare obviously a daunting task since depending on your preferred source of information there are between 30,000 and 63,000 known "viruses" out there! As discouraging as this may sound there is also no shortage of good advice on how to establish some lines of defense and how to recover if your defenses fail. One of the common themes in this advice is to select and deploy at least one and possibly more Anti-virus Software packages.
Bio-Informatics – Review on Current Research and Evolution of Cancer Targeted Therapies

The statistics shows that 7 million people die each year worldwide from cancer related cases & by 2020 this number will be more than around 16 million as methods of cancer treatment & cancer classification have become most challenging. So, cancer has become a noted disease responsible for major death rate. 200 different types of cancers are identified but some of them like lung, liver, stomach, colorectal, breast, oesophagal are leading death count. More than 60% of world’s total new cases occur in Africa, Asia and Central and South America per annum. These regions account for 70% of the world’s cancer deaths by oesophagal cancers as reported by World Health Organization. This article reviews and discusses recent improvement in the treatment of cancer and the challenges that exist, in reduced cost & time. Development and use of bioinformatics, nanotechnology is essential for the future cancer therapeutics. Most cancer treatments work for limited number of patients and this is likely to remain true for many molecularly-targeted drugs. As a consequence, a large proportion of patients are deprived of effective treatments and it is a huge financial burden on our health care system. It is essential to develop accurate tools for delivering the right treatment to the right patient based on biological characterization of each patient's tumor. The integration of wet experiments and the use of bioinformatics analysis have become an important part of biological and clinical research of this century. If we don’t pay attention to it in future we will find a cancer patient in each family across the world. Cancer cure is really difficult but not complete hopeless. A lot of researches are being carried out in the field of bio-informatics to open up new possibilities for cancer treatments.
RET rearrangements in non–small cell lung cancer and implications for the future of precision drug development

ABSTRACT Introduction: Over the past years, we have witnessed the discovery of several oncogenic driver mutations, and the emergence of specific inhibitors with high response rates and few treatment-related adverse events. RET-rearranged lung cancers represent a small subset of lung cancers, most commonly encountered in patients with adenocarcinoma and minimal or no exposure to tobacco. Several multikinase inhibitors have been tested with high ‘off-target’ toxicity and low RET inhibition activity. Areas covered: Here, we review the main aspects of the biology of RET, the challenges of RET inhibition in lung cancers, clinical data from several multikinase inhibitors, and some future perspectives with regard to precision oncology. Expert commentary: Early phase clinical trials results of more selective RET inhibitors are eagerly awaited.
Coverage Analysis of mmWave Networks With Cooperative NOMA Systems

In this letter, a cooperative non-orthogonal multiple access (NOMA) method is utilized in millimeter wave (mmWave) communications to active non-line-of-sight (NLOS) users, where NOMA users are modeled with the aid of Poisson point process (PPP) and all users are severed by a central base station (BS). Closed-form expressions for outage probabilities of paired NOMA users are derived to characterize the performance of the proposed networks. Our numerical results show that the proposed system outperforms the traditional mmWave networks using non-cooperative NOMA.