Miracle-dz/UniFAR-FTUs huggingface dataset:
Side effects of ketamine in the long-term treatment of neuropathic pain.

OBJECTIVES Ketamine, noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, has been used in the treatment of chronic neuropathic pain for almost 15 years. The aim of the study was to describe and evaluate side effects of this drug in the group of 32 patients with diabetic polyneuropathy and with postherpetic neuralgia. DESIGN AND PATIENTS In total, 32 patients with postherpetic neuralgia and diabetic polyneuropathy were enrolled into our prospective study. The side effects were divided in two groups. First, the side effects observed within 30 minutes lasting intravenuous infusion of 10 mg of ketamine in 100 mL of normal saline. Second after 3 months of peroral treatment of 30 mg of ketamine five times daily. RESULTS Sedation was observed in 15.6% of patients after the initial infusion and in 19% of patients in the course of the subsequent oral therapy. In total, 44% (infusion) and 22% (oral administration) of patients reported dizziness. A total of 25% of patients complained about drowsiness and 19% of patients reported dry mouth during oral therapy. In the observed 3-month treatment period, five patients (15.6%) withdrew from the treatment due to a failure of therapy and four patients (12.5%) due to untolerated side effects (dizziness, sedation, loss of appetite, nausea, and vomiting). CONCLUSIONS Ketamine is evaluated as a nonoptimal, however, available NMDA blocker suitable for clinical use. Studying its effects in clinics can be expected to increase our knowledge necessary for the development of new, effective, and safe "antineuralgic drug. "
Calculation of the Mastoid Cell Volume of Infants From Computed Tomography Imaging

Objective:The objective of this study was to calculate the mastoid cell volume of infants using computed tomography imaging. Methods:We calculated the mastoid cell volumes of 87 infants younger than 1 year classified into 4 age groups. Results:There were significant (P = 0.0001) differences in the ear mastoid cell volumes (cm3) among the 0- to 3-, 4- to 6-, 7- to 9-, and 10- to 12-month age groups. Generally, the mastoid cell volume increased with age. Conclusions:Mastoid cell volume correlates with the age of infants up to 1 year. We plan to expand this study and determine cutoff values for the mastoid cell volumes of infants.
A Study of Investment Performance and Impact of Stock Analysts’ Recommendations

Information available in the market is an important source for making investment in the stock market. The objective of this study is to examine the value of analysts’ services for investors and explore the presence of announcement effects of their recommendations on the stock market return behavior. This study considers 222 buying recommendations and covers the time period from July 4, 2005 to December 31, 2007. The present study uses the Sharpe Performance Measure to capture the impact of analysts’ recommendations over the investment performance. This study shows the absence of association between abnormal return and the recommendations provided by the equity analysts. However, some interesting results in case of holding period suggest that one week holding period following the recommendations provides inferior investment performance while one year holding period yields highest inferior investment performance.
HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer.

To the Editor: Trastuzumab is a monoclonal antibody against HER2, a member of the epidermal growth factor receptor (EGFR) family, that improves the outcome of HER2-positive breast cancer.1 Preclinical data have demonstrated that trastuzumab is effective in non–small-cell lung cancer, with additive or synergistic effects with various cytotoxic agents. However, trials of trastuzumab or other HER2-targeted agents, such as pertuzumab, failed to demonstrate clinical benefit in non–small-cell lung cancer when administered as monotherapy or combined with chemotherapy.2 In these studies, HER2 status was assessed by immunohistochemical analysis, a method that is not optimal.3 Moreover, the few patients whose tumors had .
Effects of Salt on Wheat Flour Dough Fermentation

Most food chemistry characteristics in the dough fermentation of salt are not solved. Effects of salt on the acceleration process of wheat flour dough fermentation were studied, respectively. The mechanism of dough expansion influenced by salt and yeast was also investigated. The dough expansion rate with no salt reached a maximum of 18% in the 50 min dough fermentation time. In contrast, dough with 2.0% salt reached an expansion rate of 96% in 30 min of fermentation. Furthermore, the maximum dough expansion rate with 8.0% salt was 58% in 20 min. Lipid peroxidation catalyzed by baker's yeast was observed in the dough fermentation process following the addition of salt. Although the baker's yeast catalyzed lipid peroxidation salt triggered the reaction. The hydroperoxide produced in the induced lipid peroxidation reaction was found to play an unspecified role in the expansion phenomenon of dough. Based on these findings, we examined how salt is associated with the dough fermentation phenomenon. We hypothesized that the presence of salt would induce the following two chemical phenomena: 1) Salt enhances cross-linkages between gliadin and glutelin, which in turn leads to increased gluten content. 2) While baker's yeast catalyzes lipid peroxidation, salt potentiates this reaction. We speculated that hydroperoxide, produced in lipid peroxidation, would accelerate the dough fermentation process, thereby resulting in a higher dough expansion rate. These results revealed some new findings in the biochemical effects of salt in bread making, which could break new ground in the bread-making industry.
What Factors are Perceived to Influence Consideration of IFRS Adoption by Vietnamese Policymakers?

International Financial Reporting Standards (IFRS) developed by the International Accounting Standards Board (IASB) are designed to be a single high quality set of global accounting standards. IFRS were originally developed to serve the listed companies in developed capital markets. However, IFRS are increasingly being adopted by emerging economies, disregarding the concerns of the relevance and appropriateness of IFRS to those economies. It has been argued that emerging economies had little choice but to proceed with IFRS upon pressures from external forces. This paper users survey evidence to examine the perceptions of Vietnamese accountants regarding pressures for IFRS adoption on Vietnamese policymakers. Although the Ministry of Finance of Vietnam announced its intention to align Vietnamese accounting legislation with IFRS in November 2013; they have not yet determined the roadmap and pathway for IFRS adoption or convergence. The findings may allow the accounting practitioners, educators, and policy makers to prepare themselves for the change that Vietnam might pursue regarding IFRS.
Epigenetic regulation of the Igf2/H19 gene cluster

Igf2 (insulin‐like growth factor 2) and H19 genes are imprinted in mammals; they are expressed unevenly from the two parental alleles. Igf2 is a growth factor expressed in most normal tissues, solely from the paternal allele. H19 gene is transcribed (but not translated to a protein) from the maternal allele. Igf2 protein is a growth factor particularly important during pregnancy, where it promotes both foetal and placental growth and also nutrient transfer from mother to offspring via the placenta. This article reviews epigenetic regulation of the Igf2/H19 gene‐cluster that leads to parent‐specific expression, with current models including parental allele‐specific DNA methylation and chromatin modifications, DNA‐binding of insulator proteins (CTCFs) and three‐dimensional partitioning of DNA in the nucleus. It is emphasized that key genomic features are conserved among mammals and have been functionally tested in mouse. ‘The enhancer competition model’, ‘the boundary model’ and ‘the chromatin‐loop model’ are three models based on differential methylation as the epigenetic mark responsible for the imprinted expression pattern. Pathways are discussed that can account for allelic methylation differences; there is a recent study that contradicts the previously accepted fact that biallelic expression is accompanied with loss of differential methylation pattern.
The Impact on Russia of WTO Accession and the Doha Agenda: The Importance of Liberalization of Barriers Against Foreign Direct Investment in Services for Growth and Poverty Reduction

Taking price changes from the Global Trade Analysis Project (GTAP) model of world trade, the authors use a small open economy computable general equilibrium comparative static model of the Russian economy to assess the impact of global free trade and a successful completion of the Doha Agenda on the Russian economy, and especially on the poor. They compare those results with the impact of Russian accession to the World Trade Organization (WTO) on income distribution and the poor. The model incorporates all 55,000 households from the Russian Household Budget Survey as"real"households. Crucially, given the importance of foreign direct investment (FDI) liberalization as part of Russian WTO accession, the authors also include FDI and Dixit-Stiglitz endogenous productivity effects from liberalization of import barriers against goods and FDI in services. The authors estimate that Russian WTO accession in the medium run will result in gains averaged over all Russian households equal to 7.3 percent of Russian consumption (with a standard deviation of 2.2 percent of consumption), with virtually all households gaining. They find that global free trade would result in a weighted average gain to households in Russia of 0.2 percent of consumption, with a standard deviation of 0.2 percent of consumption, while a successful completion of the Doha Development Agenda would result in a weighted average gain to households of -0.3 percent of consumption (with a standard deviation of 0.2 percent of consumption). Russia, as a net food importer, loses from subsidy elimination, and the gains to Russia from tariff cuts in other countries are too small to offset these losses. The results strongly support the view that Russia's own liberalization is more important than improvements in market access as a result of reforms in tariffs or subsidies in the rest of the world. Foremost among the own reforms is liberalization of barriers against FDI in business services.
NUTRITION ISSUES IN GASTROENTEROLOGY , SERIES # 43 Serum Proteins as Markers of Nutrition

IDENTIFYING MALNUTRITION The high incidence of malnutrition in the hospital setting was first described in the 1974 publication, “The Skeleton in the Hospital Closet” (1). Over time, the presence of malnutrition has been consistently correlated with increased length of stay, clinical deterioration, increased use of hospital resources, and increased risk of complications (2). Because of the deleterious effects of malnutrition on morbidity and mortality, identifying patients at nutritional risk early should improve outcomes and decrease costs. However, malnutrition is sometimes difficult to define. Is malnutrition a deficiency in caloric intake, protein intake, or a deficiency in both? Could a deficiency in micronutrients such as vitamins and minerals be defined as malnutrition? Is malnutrition defined by a specific clinical condition, or is it the presence of multiple conditions? Although there is no clear consensus among health care NUTRITION ISSUES IN GASTROENTEROLOGY, SERIES #43
Malassezia spp.-specific immunoglobulin E level is a marker for severity of atopic dermatitis in adults.

The significance of allergen-specific IgE as marker for severity of atopic dermatitis is controversial. The aim of this study was to determine the frequency of IgE-mediated sensitisation to food and environmental allergens in 132 children and 67 adults with atopic dermatitis, and its correlation to severity of atopic dermatitis (SCORAD). Total IgE was elevated (> 100 kU/l) in 79.7% of adults and 46.8% of children. Sensitisation frequencies to allergens, particularly microbial allergens, were up to 10-fold higher in adults compared to children. Severity of atopic dermatitis correlated with elevated total IgE in adults (r = 0.549, p < 0.001) and children (r = 0.344, p = 0.005) and with Malassezia spp. -specific IgE in adults (r = 0.429, p = 0.007). Total IgE is a marker for severe atopic dermatitis in both age groups. Malassezia spp. -specific IgE is an important allergen-specific marker for severity of atopic dermatitis in adults.
Network Forensics Analysis

Many tools let you view traffic in real time, but real-time monitoring at any level requires significant human and hardware resources, and doesn't scale to networks larger than a single workgroup. It is generally more practical to archive all traffic and analyze subsets as necessary. This process is known as reconstructive traffic analysis, or network forensics. In practice, it is often limited to data collection and packet-level inspection; however, a network forensics analysis tool can provide a richer view of the data collected, allowing you to inspect the traffic from further up the protocol stack? The IT industry's ever-growing concern with security is the primary motivation for network forensics. A network that has been prepared for forensic analysis is easy to monitor, and security vulnerabilities and configuration problems can be conveniently identified. It also allows the best possible analysis of security violations. Most importantly, analyzing a complete record of your network traffic with the appropriate reconstructive tools provides context for other breach-related events.
Cluster analysis and market segmentation

Suggests that segmentation technology has become increasingly sophisticated in recent years and the role of multi‐dimensional techniques in marketing analysis is increasingly being recognised. Proposes that rather than segmenting a market by one or two criteria, cluster analysis enables segmentation to be made on many dimensions simultaneously. Concludes that the scope for marketing initiative is widened by this powerful segmentation procedure.
LOGISTICS MANAGEMENT BASED ON DEMAND FORECASTING

The companies of any industry are strongly affected with current globalization trend, which makes supply chain flows more and more bulky and complex. To be competitive in cost and eco-friend way under contemporary business market conditions, the companies should apply system approach of logistics management to plan, manage and control of their logistics processes. Each company's system can be analysed and divided into essential logistics sub-systems: purchasing, production, packaging, warehousing, distribution and reverse material flow management. Thus, the system and process approach are crucial for up-to-date logistics systems or subsystems management in context of long-term sustainable growth. Any effective logistics management system should be based on sub-system of demand forecasting. Demand forecasting is increasingly getting important to make right managerial decisions. Well developed demand forecasting sub-sytem in a company is a ground for effective planning, management and control of all company's processes then also for effective logistics or supply chain management.
Credibility of University Websites in Tamil Nadu

The influence of information and communication technology (ICT) in developing countries makes more demand for web-based reliable information. Many user studies confirm that, being able to trust the information on a website is very important to them in deciding to visit a website. Application of ICT and web hosting in an academic environment has increased gradually in the recent decades. This paper aims to study and analyse the various aspects of the credibility of university websites in Tamil Nadu. A total of 43 universities in Tamil Nadu were considered which include 17 affiliated and 21 private universities. The analysis of the data represents the extent and the level of credibility possessed by the universities’ websites in Tamil Nadu. http://dx.doi. org/10.14429/djlit.29. 248
Endothelial Cell Migration on Fibronectin Is Regulated by Syntaxin 6-mediated α5β1 Integrin Recycling*

The α5β1 integrin heterodimer regulates many processes that contribute to embryonic development and angiogenesis, in both physiological and pathological contexts. As one of the major adhesion complexes on endothelial cells, it plays a vital role in adhesion and migration along the extracellular matrix. We recently showed that angiogenesis is modulated by syntaxin 6, a Golgi- and endosome-localized t-SNARE, and that it does so by regulating the post-Golgi trafficking of VEGFR2. Here we show that syntaxin 6 is also required for α5β1 integrin-mediated adhesion of endothelial cells to, and migration along, fibronectin. We demonstrate that syntaxin 6 and α5β1 integrin colocalize in EEA1-containing early endosomes, and that functional inhibition of syntaxin 6 leads to misrouting of β1 integrin to the degradation pathway (late endosomes and lysosomes) rather transport along recycling pathway from early endosomes; an increase in the pool of ubiquitinylated α5 integrin and its lysosome-dependent degradation; reduced cell spreading on fibronectin; decreased Rac1 activation; and altered Rac1 localization. Collectively, our data show that functional syntaxin 6 is required for the regulation of α5β1-mediated endothelial cell movement on fibronectin. These syntaxin 6-regulated membrane trafficking events control outside-in signaling via haptotactic and chemotactic mechanisms.
Efficient path selection for delay testing based on partial path evaluation

In this paper, we propose an efficient path selection method for path delay testing. The proposed method selects a very small set of paths for delay testing that covers all paths. Path selection is done by judging which of two paths has the larger real delay by taking into account the ambiguity of calculated delay, caused by imprecise delay modeling as well as process disturbance. In order to make precise judgement under this ambiguity, the delays of only unshared segments between the two paths are evaluated. This is because the shared segments are presumed to have the same real delays on both paths. Experimental results show the method can select about one percent of the paths selected by a conventional method without decreasing fault coverage.
Synergistic activity of components of mycobacteria and mutant Salmonella in causing regression of line-10 tumors in guinea pigs.

Intratumor injections of oil-in-water emulsions containing mycobacterial whole-cell extraction residues, cell walls, or cell wall skeletons combined with a phenol:water extract of heptoseless (Re) mutant Salmonella typhimurium produced high percentages of regression of line 10 hepatocellular carcinomas in strain 2 guinea pigs. Injection of one of the mycobacterial components plus Salmonella extract cured higher percentages of tumor-bearing animals than did treatment with either microbial substance alone. Mycobacterial whole-cell extraction residues and cell wall skeletons exposed to hydrochloric acid, potassium hydroxide, or organic solvents produced residues with varying antitumor activity. Interaction of these microbial substances with oil droplets was measured by determining the nitrogen content of the oil and aqueous phases of oil-in-water emulsions containing the test substances. A linear, positive correlation was found between tumor regressive activity and capability of the mycobacterial substances to interact with oil droplets of oil-in-water emulsions. However, interaction of radiolabeled Salmonella extract and radiolabeled cell wall skeleton with oil droplets revealed that neither of these materials affected the binding of the other with oil droplets. Thus, the synergistic antitumor activity obtained by combined treatment with cell wall skeleton and Salmonella extract was not a consequence of the enhanced interaction of the microbial materials with the oil phase of the therapeutic oil-in-water emulsions. Presumably, the synergistic antitumor effect of combined therapy was due to individual, host-mediated responses to the two microbial substances. These as yet unknown biological responses culminated in expression of potent tumor regressive activity.
Minimizing Maximum Promptness and Maximum Lateness on a Single Machine

We consider the following single-machine bicriteria scheduling problem. A set of n independent jobs has to be scheduled on a single machine that can handle only one job at a time and that is available from time zero onwards. Each job Jj requires processing during a given positive uninterrupted time pj, and has a given target start time sj and due date dj with A ≤ dj-sj ≤ A + pj for some constant A. For each job Jjj = 1,. , n, its promptness Pj is defined as the difference between the target start time and the actual start time, and its lateness Lj as the difference between the completion time and the due date. We consider the problem of finding a schedule that minimizes a function F of maximum promptness Pmax = max1≤j≤nPj and maximum lateness Lmax = max1≤j≤nLj; we assume that F is nondecreasing in both arguments. We present an On2 algorithm for the variant in which idle time is not allowed and an On2 log n algorithm for the special case in which the objective function is linear. We prove that the problem is NP-hard if neither of these restrictions is imposed. As a side result, we prove that the special case of minimizing maximum lateness subject to release dates that lie in the interval [dj-pj-A, dj-A], for all j = 1,. , n and for some constant A, is solvable in On log n time if no machine idle time is allowed and in On2 log n time if machine idle time is allowed.
The Egyptian Stock Market: Efficiency Tests and Volatility Effects

The paper examines the behavior of stock returns in the Egyptian stock exchange, the efficiency of the market in pricing securities, and the relationship between returns and conditional volatility. GARCH(p,q)-M models estimated for the four best known daily indices indicate significant departures from the efficient market hypothesis; the tendency for returns to exhibit volatility clustering; and a significant positive link between risk and returns, which was significantly affected during the market downturn that followed the introduction of circuit breakers in the form of symmetric price limits on individual shares.
Sexual Life During Pregnancy: Effect of an Educational Intervention on the Sexuality of Iranian Couples: A Quasiexperimental Study

ABSTRACT The sexual life of couples and their needs during pregnancy receive little attention in practice. The aim of this study was to evaluate an educational intervention delivered to pregnant couples to improve their sexual function and satisfaction. This quasiexperimental study was conducted on 128 couples, allocated into two groups of intervention (group A: couples, group B: pregnant women) and one control group (C). Postintervention, the mean of the total score of sexual function and satisfaction of the couples was significantly higher in the intervention groups compared with the control group (p < 0.05). It seems sexuality education specific for prenatal care would be effective.