Miracle-dz/UniFAR-FTUs huggingface dataset:
SpringerBriefs in Space Life Sciences Series Editors

This chapter will give a short overview on the first systematic analysis concept and first results on the resistance of biomolecules to space and Mars-like conditions realized on the exposure platform EXPOSE-R2 on the International Space Station (ISS). This platform in Low Earth Orbit (LEO) was chosen, because on ground even the best space and planetary simulation chambers are not able to cover all relevant environmental conditions, we might encounter directly in space or on Mars. A much better approach can only be realized directly in space and particularly on the long-term existing platform in Earth’s orbit. It shows also the increased value the ISS has gained for astrobiological planetary research with its main topics of “habitability of planets,” “limits of life,” and “the search for life beyond Earth. ” The results presented here are mainly based on the successful space exposure experiment BIOMEX (BIOlogy and Mars EXperiment). The outcome of these and also previous and future space exposure experiments have direct implications for future space missions with the main goal to search for life in the solar system and beyond.
Über die Dynamik der frühen Embryogenese des Caenorhabditis elegans

The small nematode Caenorhabditis elegans is one of the major model systems in modern developmental biology due to its almost invariant embryogenesis. For example, cell trajectories and many properties of cell divisions are almost the same for each individual. This thesis aims at elucidating the reasons for the observed reproducibility, based on a previously established mechanical model that reproduces experimentally obtained cell trajectories [1, 2]. Within this model, cell organization is determined by the cells' quest for positions with least repulsive interactions among themselves and the eggshell. Since this model cannot capture properties of cell divisions, the embryogenesis of Caenorhabditis elegans has been observed by uorescence light sheet microscopy in four dimensions. The acquired data allow the quanti cation of cell positions and volumes in a time-dependent manner. These data reveal that the rigid chitin eggshell surrounding the embryo is crucial for deterministic cell trajectories. Furthermore, uctuations in the ambient temperature only rescale the biological clock without in uencing cell arrangements qualitatively. Geometric asymmetries of cell divisions are quanti ed for the rst time. It turns out that around 40% of early cell divisions are signi cantly asymmetric. While this is induced by steric e ects in somatic cells, asymmetries in the germline are caused by a shift of the mitotic spindle. The magnitude of this shift is decoupled from cell size, which can be explained by a mechanical model. In addition, the volumes of cell nuclei during interphase are quanti ed. Nuclei grow with an exponential scaling towards asymptotic volumes that correlate linearly with cell volumes. Growth is independent of temperature and faster in small cells. Hence, data suggest a di usion-based partitioning mechanism of a limiting component. Furthermore, it is shown that cell cycle durations, i.e. the time between two successive cell divisions, are anticorrelated with cell volumes. This scaling can also be rationalized quantitatively with a model based on limiting components. With these results the mechanical modelling of cell trajectories can be formulated in a signi cantly more self-contained fashion. Finally, using that model, it can be shown that deviations from unperturbed properties of cell divisions markedly reduce the stability of embryogenesis.
CRISPR-Pass: Gene Rescue of Nonsense Mutations Using Adenine Base Editors

A nonsense mutation is a substitutive mutation in a DNA sequence that causes a premature termination during translation and produces stalled proteins resulting in dysfunction of a gene. Although it usually induces severe genetic disorders, there are no definite methods for inducing read-through of premature termination codons (PTCs). Here, we present a targeted tool for bypassing PTCs, named CRISPR-pass that uses CRISPR-mediated adenine base editors. CRISPR-pass, which should be applicable to 95.5% of clinically significant nonsense mutations in the ClinVar database, rescues protein synthesis in patient-derived fibroblasts, suggesting potential clinical utility.
Allowing Lay People to Manage Smart Objects in the Cultural Heritage Domain

Cultural heritage is a legacy of the past to be transmitted to present and future generations to help fostering their cultural identity. Information technology can support greater awareness and appreciation of historical content. In particular, the Internet of Things (IoT) has emerged as a very promising technology able to enhance the access to CH collections. IoT systems are based on distributed software services that, through the Internet, enable the access to functionality and data provided by physical devices. These are the so-called smart objects [1], i.e., devices generally equipped with sensors (able to detect different types of events occurring in an environment) and/or actuators (able to enact some actions determining a state change in the environment or in the IoT system itself). Through this technology, it is possible to create smart visit experiences offering to visitors of CH sites objects that they can bring with themselves, touch and manipulate for experiencing the site by receiving personalized information [2-4]. The interaction with such tangible objects favour emotions and engagement, improves understanding, thus increases the appropriation of CH content [2]. Some works in the literature recognize the benefits of physical manipulation and action as an additional channel for conveying information, since they activate real-world knowledge and improve memory [5, 6].
Effective and Efficient Approach for Graph De-Anonymization

: Ever since social networks became the focus of a great number of researches, the privacy risks of published network data have also raised considerable concerns. To evaluate users’ privacy risks, researchers have developed methods to de-anonymize graphs and identify same person in different graphs, yet the existing algorithms either requires high-quality seed mappings, or have low accuracy and high expense. In this paper, an effective and efficient seedless de-anonymization algorithm, “RoleMatch” is proposed. This algorithm is based on the network topology and consists of (1) a new cross-graph node similarity measurement “RoleSim++” with fast computation method
Nature of Disordered Sleep in Patients with Moderate to Very Severe Chronic Obstructive Pulmonary Disease

Introduction: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the world. Comorbidities occur frequently in COPD patients. Aim: The present study was an observation based cross-sectional prospective study carried out with an aim to evaluate the breathing disorders during sleep in patients with COPD and to correlate this disorder with the stage of the disease. Materails and Methods: A total of 50 patients were eligible for participation in our study. 18 patients had moderate COPD, 19 patients had severe COPD, and 13 patients had very severe COPD as per the global initiative for chronic obstructive lung disease guidelines. Results: Mean sleep efficiency was low at 53.25 ± 18.15. Sleep latency was normal in three patients only. We found abnormal sleep architecture in all three groups with decreased duration of stage N3 and stage rapid eye movement. Obstructive sleep apnea (OSA) was present in 23 of 50 subjects of COPD (Overlap syndrome). Conclusion: In present study, it was found that OSA is highly prevalent in patients with moderate to very severe COPD. Sleep quality is also poor among this selected group.
The Syntax Phonology Interface of Mood Particles in Mandarin Chinese

The present thesis focuses on the syntactic study of the position of mood particles in Mandarin Chinese. The most popular mood particles in Mandarin Chinese are six: “ne”, “a”, “ma”, “ba”, “le” and “de”, used at the end of the sentences, traditionally believed to denote interrogative, declarative, imperative, and exclamative moods. This thesis argues that the mood particles don’t carry any lexical meanings themselves, and as sentence affixes, they are adjoined to the head complementizer at the end of the sentence in head final language of Chinese at the sensorimotor interface after the spellout in PF level. Therefore, mood particles are not computed in the internal grammar but in the externalization process of the computation.
INTERNAL STRAIN MEASUREMENT OF GLASS-POLYESTER COMPOSITES UNDER HYGRO-THERMAL AGEING TEST USING FIBER BRAGG GRATINGS

This study is devoted to the identification of the moisture expansion coefficients of composite materials by means of a novel method of measurement . This method is based on the insertion of Fiber Bragg Grating (FBG) sensors in the composi te structure. The sensor enables to measure the hygroscopic strain induced by the diffu sion of moisture in the composite. The evolution of the strain, due to the moisture absorp ti n, was represented according to the water uptake, in order to characterize the moisture expansion coefficient.
Integrating thematic Maps into Storyline Visualizations Master 2 Internship

In several domains, the exploration of relationships among entities of different types are part of practitioners’ daily work. For example, in journalism, news articles that report on the cities visited by two politicians during an election campaign can be useful to explain the voting results in those cities later. Datasets that describe such relationships can be difficult to visualize and to explore, especially when dealing with a large number of entities and relationships. Storyline visualizations, that became popular with Randall Munroe narrative movie charts in XKCD comics [4], can accommodate such datasets and show the relation among people over time. In these charts, each character is represented by an horizontal line, whose length represents their lifespan in the movie. Lines converge to meet other lines when the characters interact in the movie, and diverge when they move apart. Figure 1 shows an example of this visualization for Episode V, The Empire Strikes Back of the Star Wars.
Understanding and Measuring Income Shocks as Precursors to Poverty

Poverty and economic hardship are multi-faceted and dynamic phenomena impacting over 50 million people in the United States and billions of people world-wide. Despite the prevalence of poverty, there remains much to be understood about what makes families susceptible to experiencing economic distress and what interventions many be effective and for which families. An important set of questions is related to the role of income shocks. Shocks may constitute unexpected expenses such as a medical bill or a parking ticket or interruptions to one’s income flow, such as a delayed paycheck or loss of public benefits. Recently these phenomena have garnered increased attention, with a growing body of empirical and computational work showing their impact on various measures of socioeconomic welfare. We present a computational study of a large survey-based longitudinal data-set to understand the role of shocks on poverty. We ask whether and which shocks hold predictive power in identifying families that will experience poverty, and whether there exist differences between different demographic groups. We then examine what relationships exist between different types of shocks themselves, showing that certain shocks may make families susceptible to experiencing further shocks. E.g., families that experience a medical shock are nearly four times more likely to experience another medical shock and nearly twice as likely to experience an income decrease within three months. We further reveal that the co-occurrence of shocks can yield insights about which families are likely to experience poverty. Synthesizing these results as well as numerous conversations with researchers and practitioners from the Poverty Tracker study, we present a discussion of how such computational techniques can inform poverty-alleviation programs and social work practice.
THE INFLUENCE OF POWER STRATEGIES IN INFORMATION SYSTEMS (IS) IMPLEMENTATION PROCESSES

: This study is based on a longitudinal in-depth case study that was conducted in a Portuguese public sector organization. We investigated how the implementation processes of two information systems (IS) were influenced by power strategies, under the power dimensions proposed in Hardy’s (1996) framework. The study’s contributions include: an extension of this framework concerning the “power of the system”; evidence that power was exercised in a non-threatening way; and that each strategic dimension of power was interrelated to the other dimensions.
ANTICONVULSANT PROPERTIES OF ISOMERS OF DICHLOROPHENYL AMINO PROPANAMIDES IN MICE

Antiepileptic drug development is a dynamic process, affording many research opportunities. Continued efforts are being made in the development of antiepileptic drugs employing a range of strategies, including modification of the structures of existing drugs, targeting novel molecular substrates and non-mechanism-based drug screening. This research was aimed at evaluating the anti-seizure effects of three isomers of diclorophenyl propanamides (DCP), viz; 2,3(DCP23)-, 2,5(DCP25) and 3,4(DCP34) dichloro-substituted phenyl propanamides, using chemicallyand electricallyinduced seizure models. In 4-aminopyridine-induced seizure test, there was no protection offered by the three compounds, but DCP34 at doses of 50 mg/kg and 25 mg/kg exhibited significant (p < 0.05) increase in the onset of seizures. The compounds did not offer protection in strychnine-induced seizure test. In picrotoxin-induced seizure test, DCP23 and DCP25 offered protection against clonic convulsion of 66.7% and 83.3% at 50 mg/kg; 50.0% and 66.7% at 25 mg/kg, respectively. Single oral administration (100 mg/kg) of the compounds (DCP23, DCP25 and DCP34) produced 37.5%, 50% and 0.0% protections respectively against tonic hind limb extension (THLE) while a 5-day administration offered higher protection of 50%, 75% and 25% respectively. When DCP23 or DCP25 (25 mg/kg), was co-administered with nickel chloride (5 mg/kg), the percentage protection against PTZ-induced seizure was better (66.67% and 33.33% respectively) than when administered separately. These compounds possess anticonvulsant activity and could be optimized to develop potential lead compound with antiepileptic effect.
Determinants of Capital Structure – A Study of Oil and Gas Sector of Pakistan

Capital structure decisions have been the most significant decisions to be taken by the finance experts in a corporate sector organization. The study intends to analyze the effect of profitability, tangibility, size and liquidity on capital structure decisions of the listed companies in oil and gas sector of Pakistan. The study attempts to provide information that may help in taking capital structure decisions in listed companies of oil and gas sector of Pakistan, which will ultimately support in maximization of the value of firms on the one side and the minimization of cost of capital on the other side. The results indicated that profitability is the only variable that showed negative relationship against the dependent variable leverage, whereas the other three variables, liquidity, size and tangibility have positive relationship with leverage. The study concludes that capital structure decisions in listed oil and gas sector companies are mostly determined by the factors studies. The study substantiates the findings of most of the researches conducted on capital structure, concluding that there is an optimal capital structure that is affected by a variety of internal and external factors.
Leadership Comparison Model at Higher University: Contingency Friendler Method; Path-Goal Theory Method and Harsey and Blanchard Method

This research aim is to analyze the University leadership model. It uses friedler contingency, path-goal theory and Harsey and Blanchard methods. This study focuses on problem of poor leadership in universities. The research approach is descriptive-qualitative. The results of Friedler model show that leaders performance depend on two interrelated aspects: (a) leader ability to control and influence; (b) the leader basic motivation in relation to task with others. Path goal theory identifies four leadership styles: (a) Directive Leadership; (2) Supportive Leadership; (3) Participative Leadership and (4) Achievement Oriented Leadership. Harsey's and Blanchard's theory showed the effective leader behavior depends on readiness level the followers. The readiness is defined as the ability and willingness level of followers to accomplish the tasks of four specific leader behaviors: (1) telling (level of task orientation); (2) Selling (high-task orientation high relationship), leaders provide steering behavior and supportive behavior; (3) Participating (low task orientation high relationship) and (4) Delegating (low task orientation low relationship).
Associations of Sexual Function and Personality Traits among Medical Students of Lithuanian university of Health Sciences

Introduction. Sexual function depends on biological, socio-cultural, and psychological factors such as person’s individual characteristics – traits. After formation of gender studies as a separate branch of science, the interest increased in connection between sexual function and personality disorders, and/or connection of personality traits with the sexual function, however there have been relatively few studies to assess the interface of sexual function and personality traits among the population of healthy and young people.
Analyzing Sentiment of Myanmar Movie Comments Using Naïve Bayes Classifier

 Abstract — Sentiment analysis is extremely useful in social media monitoring as it allows us to gain an overview of the wider public opinion behind certain topics. It is also the use of Natural Language Processing (NLP) to analyze social comments and determine a deeper context. Due to little research has been done in the domain of Facebook sentiment classification about Myanmar movie comments, this system aims to determine the overall reaction of the movie using Naïve Bayesian machine learning technique. The objective of this system is to extract movie features from the comments, classify the comments into positive and negative and predict the overall polarity of the comments. In the data preparation phase, the system collects movie comments written by Myanmar language in Facebook as a dataset and these comments are first cleaned to reduce noise. Text pre-processing is also done on Myanmar Word Segmentation Version 1.0 of UCSY and movie features are extracted. Classification is made by using Naïve Bayes approach that gives rise to a probabilistic classifier. For evaluation, 10-fold cross validation which is a standard machine learning assessment technique has been performed on a balanced data set of the movie comments. And the performance of the proposed approach was also evaluated using F-measure.
PSYCHOLOGICAL STRESS AND ORAL DISEASES – A LINK ?

INTRODUCTION Epidemiologic studies and clinical observations suggest that negative life events and psychological factors may contribute to an increased susceptibility to periodontal disease. Stress a term continually being redefined in the scientific study of disease and illness, is nevertheless a confirmed and important factor in the etiology and maintenance of many inflammatory diseases, including periodontal disease. stress is an attempt to understand how the body regulates itself to maintain smooth, adaptive and homeostatic functioning when confronted with disruptive endogenous or exogenous forces. Hippocrates thought of health as a harmonious balance of the elements comprising the quality of life while disease represented disruption or disharmony among those elements. In the seventeenth century, Sydenharm suggested that pathological states represented diseases of adaptation failure of the adaptive processes to restore wellbeing. Cannon elaborated how fight or flight mechanisms represented adaptive efforts by the body to reestablish homeostasis, a term he introduced to describe a dynamic internal physiological equilibrium which the body sought to maintain along both physical and emotional dimensions.
Physical properties and crystallization of theophylline co-crystals

This work focuses on the physical properties and crystallization of theophyline co-crystals. Co-crystals of theophylline with oxalic acid, glutaric acid and maleic acid have been investigated. The DSC curves of these co-crystals show that their first endothermic peaks are all lower than the melting temperature of theophylline. The decomposition temperature of theophylline – oxalic acid co-crystal is at about 230 °C, determined by DSC together with TGA. After decomposition, the remaining theophylline melts at about 279 °C, which is higher than the known melting temperature of theophylline, suggesting a structure difference, ie. a new polymorph may have been formed. The formation of hydrogen bonds in theophylline – oxalic acid co-crystal was investigated by FTIR. Changes of FTIR peaks around 3120 cm-1 reflects the hydrogen bond of basic N of theophylline and hydroxyl H of oxalic acid. The solubility of theophylline – oxalic acid co-crystal and theophylline – glutaric acid co-crystal was determined in 4:1 chlroform – methanol and in pure chloroform respectively. At equilibrium with the solid theophylline – oxalic acid co-crystal, the theophylline concentration is only 60 % of the corresponding value for the pure solid theophylline. At equilibrium with the solid theophylline – glutaric acid co-crystal, the theophylline concentration is at least 5 times higher than the corresponding value for the pure solid theophylline. Two phases of theophylline were found during the solubility determination. In the chloroform – methanol mixture (4:1 in volume ratio) the solubility of the stable polymorph of theophylline is found to be about 14 % lower than that of the metastable phase. Various aspects of the phase diagram of theophylline – oxalic acid co-crystal was explored. Theophylline – oxalic acid co-crystal has been successfully prepared via primary nucleation from a stoichiometric solution mixture of the two components in chloroform – methanol mixture. By slurry conversion crystallization, the co-crystal can be prepared in several solvents, and yield and productivity can be significantly increased. Theophylline – glutaric acid can be successfully prepared via both co-grinding of the two components and slow evaporation with seeding.
Local production and / or delivery methods of anticancer agents by stromal cell precursors

本発明は、過剰増殖性疾患を有する対象を治療するための、遺伝的に改変された間葉系幹細胞を含む組成物の使用、およびそれを作製するための方法に関する。 いくつかの態様は、作用物質単独での全身送達を回避しながら、作用物質の局所送達を可能にする。 生体物質を腫瘍部位で局所的に産生させるためにストローマ前駆体を用いることもできる。 腫瘍微小環境または増殖を誘導するその他の微小環境は、他の組織に比してストローマ前駆体の生着を選択的に促進する。