Miracle-dz/UniFAR-FTUs huggingface dataset:
On quadruped attitude dynamics and control using reaction wheels and tails

This paper studies the attitude dynamics and the control of quadruped robots using tail-like appendages during the flight phases of high speed locomotion. Inspiration and data are first obtained from cheetah's fast galloping techniques. A two-body template is then used to simply describe the dynamics of a large body whose attitude is controlled by a rotating appendage. The equations of motion for a tail and a reaction wheel are given, while by employing cyclic coordinates, all possible reductions are performed to finally lead to the design of model-based controllers. A main contribution lies on the thorough discussion on the holonomy of the system, which only depends on the system's geometry and the initial angular momentum. A comparison between a reaction wheel and a tail is also carried out, while basic steps and formulas are proposed for selecting the key parameters concerning the design of such systems. Finally, simulation results are presented in order to validate the methods proposed herein.
A design for object tracking security system using on LED light combined CCTV

In this paper, object tracking security system combined with LED(light-emitting diode) light and CCTV (Closed circuit television) is proposed. CCTV of proposed system is possible to adjust the angle and move to the wanted direction. First, this study uses the sensor combined US(UltraSonic) and IR(Infrared) sensor for tracking the object of the human body and designs the driver of LED for LED light control that is possible to operate together the tracking the human's body. In addition, we propose LED spot light system that can shoot a light to the direction of human and the convergent system of LED spot light system and object tracking security system combined with LED light and CCTV. Finally, the usefulness of the proposed system is confirmed through implementing an integrated control system and the core hardware.
Pharmacodynamic and pharmacokinetic measurements of antitumor agents

Blood level assays of antitumor drugs in the mouse, rat, hamster, dog, monkey, and man were done to determine the toxicologic and therapeutic responses by species. F or cyclophosphomide and amethopterin, the predicted maximum tolerated dose for man, based on all animal data, correlated rrwre closely with clinical toxicity when related to body surface area thon to body weight. Doses of 18 drugs including antimetabolites, alkylating agents, and other antitumor agents carried to the toxicologic end point, LD10 in small animals, the maximum tolerated dose (MTD) in dogs and monkeys, showed that the ratios of animal/human toxicity on the mg per square meter basis were remarkably close to unity. Also, when doses are expressed on this basis, equal doses give equivalent values in difJerent species for the area under the serum curve, i.e., the product of drug concentration × time, C × T (µg/ml × minutes). Three agents, arabinosylcytosine (ARA‐C), methotrexate (MTX), and CTX, selected for their differential presumed sites of primary biochemical action and the concept of unbalanced growth and cell death, were studied for the interrelationships between dosage, schedule, and blood levels and turrwr response in the L1210 leukemia system. The optimal schedules both regarding the total tolerated dose and increase in host life span vs untreated control subfeets difJered fOT the three classes of agents. The difJerences may be related to the difJering mechonisms of action, e.g., ARA‐C, which inhibits deoxyribonucleic acid (DNA) synthesis, killing the cells in S phase; MTX, which inhibits DNA, ribonucleic acid (RNA), and protein synthesis, may destroy only proliferative integrity in S phase; and alkylating agents, which complex with DNA may affect proliferative integrity, regardless of cell cycle phase. Clinical results in adults with acute myelogenous leukemia (AML) treated with ARA‐C indicate that the principles of optimal scheduling developed in the mouse L1210 system are applicable to this disease in humans. Optimal scheduling of MTX in the treatment of L1210 leukemia, human acute lymphocytic leukemia, and choriocarcinoma is also similar. The clinical results of long‐term, tumor‐free survivors in some patients with disseminated Burkitt's lymphoma on a single high dose of CTX or several high doses at appropriate intervals are not inconsistent with the data obtained in the L1210 system.
3DTown: The automatic urban awareness project

In this work the goal is to develop a distributed system for sensing, interpreting and visualizing the real-time dynamics of urban life within the 3D context of a city focusing on typical, useful dynamic information such as walking pedestrians and moving vehicles captured by pan-tilt-zoom (PTZ) video cameras. Three-dimensionalization of the data extracted from video cameras is achieved by an algorithm that uses the Manhattan structure of the urban scene to automatically estimate the camera pose. Thus, if the pose of the video camera changes, our system will automatically update the corresponding projection matrix to maintain accurate geo-location of the scene dynamics.
Providing Emotional Support to Children under Long-Term Health Treatments

: Patients under health treatments that involve long stays at a hospital or health centre (e.g. cancer, organ transplants and severe burns), tend to get bored or depressed because of the lack of social interaction with family and friends. Such a situation also affects the evolution and effectiveness of their treatments. In many cases, the solution to this problem involves extra challenges, since many patients need to rest quietly (or remain in bed) to their being contagious. Considering the weak health condition in which usually are these kinds, keeping them motivated and quiet represents an important challenge for nurses and caregivers. This article presents a mobile ubiquitous game called MagicRace, which allows hospitalized kinds to interact socially with one another without putting to risk their sensitive health conditions. The game does not require a communication infrastructure at the hospital, but instead, it uses a mobile ad hoc network composed of the handheld devices used by the kids to play. The usability and performance of this application was tested in two different sessions. The preliminary results show that users experienced positive feelings from this experience.
Unsupervised LTE D 2 D-Case Study for Safety-Critical V 2 X Communications

This article explores the recent 3GPP LTE D2D rel. 14 Radio Resource Management specification to identify the challenges and evaluate the potentials of Unsupervised LTE D2D (mode 2) for Safety-critical V2X Communications. It also proposes two distributed resource allocation strategies for unlicensed band access. Complementary to DSRC/ITS-G5, unsupervised LTE D2D is an opportunity to provide redundancy for ultrareliable systems, such as safety-critical V2X communications.
Advanced IPTV Services Personalization Through Context-Aware Content Recommendation

The advances in Internet Protocol Television (IPTV) technology enable new user-centric and interactive TV model, in which context-awareness is promising in making users' interaction with the TV dynamic and transparent. This paper considers user-centric personalized IPTV services applying context-awareness. We present a solution for enriched IPTV services personalization introducing context-awareness on top of IPTV architecture to gather different information on the user and his environment allowing each user to be distinguished by the system in a unique and real-time manner. Based on the different context information gathered, a novel solution for content recommendation is presented allowing to customize IPTV content according to the context of each user and his environment and hence guaranteeing better users' experience. We implemented the proposed solution on top of an IPTV platform considering the NGN IPTV architecture as a proof of concept and as a mean to evaluate the performance.
A new INDEL detection strategy based on feature extraction

Insertions and deletions (indels) are important structural variations in the human genome. Many researchers have created effective detection algorithms; however, the results include a significant amount of false discovery. Increasing the accu- racy of indel detection schemes remains a challenge. As coverage has increased, existing methods such as Pindel generate high false-discovery rates, owing to the number of reads. In order to resolve this problem, we present a new indel detection strategy. Our strategy uses related variation features, and combines the Pindel and Adaboost algorithms based on feature extraction. We utilized data from the internationally recognized 1000 Genomes Project for our simulations. The experimental results show that the new strategy effectively increases upon the accuracy of the single indel detection algorithm, and reduces the false discovery rate of the Pindel detection results.
MACC1 expression correlates with PFKFB2 and survival in hepatocellular carcinoma.

OBJECTIVE To validate the relationship between MACC1 and 6-phosphofructo-2-kinase/fructose 2, 6 bisphosphatase (PFKFB2) expression as well as its clinicopathological features and prognostic significance in hepatocellular carcinoma. METHODS By using immunohistochemistry, we investigated the MACC1 and PFKFB2 protein expression in 60 pairs of hepatocellular carcinoma and corresponding non-tumor tissues. Using the Mann-Whitney U test, the Chi-square test, Kaplan-Meier survival analysis, Cox proportional hazard regression analysis and Spearman analysis, we studied the relationship between MACC1 and PFKFB2 protein expression and postoperative overall survival (OS) of the HCC patients. RESULTS MACC1 and PFKFB2 positive staining rates were significantly higher in hepatocellular carcinoma than in the corresponding nontumor tissues (P=0.012 and 0.04, respectively). The clinicopathological features evaluation revealed that positive expression of MACC1 was associated with a high Edmondson classification (P=0.007) and advanced TNM stage (P=0.027). Similar findings were evident for PFKFB2 expression (P=0.002 and P=0.027). MACC1 and PFKFB2 positive expression was associated with a lower OS rate (P=0.004 and 0.03, respectively). Kaplan-Meier survival and Cox proportional hazard regression analyses revealed MACC1 positive expression to be a prognostic factor for postoperative OS, but PFKFB was not. CONCLUSION Highly expressed MACC1 and PFKFB2 protein were associated with TNM stage, Edmondson -Steier classification and overall survival. MACC1 may affect tumor metabolism partly through expression and phophorylation of PFKFB2.
A low-power on-chip calibration technique for pipelined ADCs

This paper proposes a new low-power on-chip calibration technique, called One-Time Calibration. Compare to the traditional calibration techniques our calibration circuit is realized fully on-chip which consumes very little power and small chip area; besides it needs no auxiliary circuits at all during the conversion. A 10-Bit 200MSps pipelined ADC using our new calibration technique is designed in a 55-nm CMOS technology. The on-chip calibration circuit only consumes a power of less than 5mW and increases the analog core chip area only by 10%. The post simulation results show that the ADC reaches an ENOB of 9.0-Bit after calibration for all conditions (−40-+85°C, ±10% VDD) at Nyquist rate.
Política económica en Colombia.

Sintesis El trabajo aborda el fenomeno del crecimiento economico a traves de diferentes corrientes y escuelas del pensamiento economico. Intenta, igualmente, mostrar como la politica economica de reciente configuracion en nuestro pais ha estado delimitada por el enfoque neoclasico en su version mas moderna. Muestra, de otra parte, las contradicciones de dicho enfoque en la praxis diaria de la politica economica y sus efectos colaterales en economias con bajo crecimiento economico como la nuestra.
Endoplasmic Reticulum Transmembrane Proteins ZDHHC1 and STING Both Act as Direct Adaptors for IRF3 Activation in Teleost

IFN regulatory factor (IRF)3 is a central regulator for IFN-β expression in different types of pathogenic infections. Mammals have various pathogenic sensors that are involved in monitoring pathogen intrusions. These sensors can trigger IRF3-mediated antiviral responses through different pathways. Endoplasmic reticulum–associated proteins stimulator of IFN gene (STING) and zinc finger DHHC-type containing 1 (ZDHHC1) are critical mediators of IRF3 activation in response to viral DNA infections. In this study, grass carp STING and ZDHHC1 were found to have some similar molecular features and subcellular localization, and both were upregulated upon stimulation with polyinosinic:polycytidylic acid, B-DNA, or Z-DNA. Based on these results, we suggest that grass carp STING and ZDHHC1 might possess some properties similar to their mammalian counterparts. Overexpression of ZDHHC1 and STING in Ctenopharyngodon idella kidney cells upregulated IFN expression, whereas knockdown of IRF3 inhibited IFN activation. In addition, coimmunoprecipitation and GST pull-down assays demonstrated that STING and ZDHHC1 can interact separately with IRF3 and promote the dimerization and nuclear translocation of IRF3. Furthermore, we also found that small interfering RNA–mediated knockdown of STING could inhibit the expression of IFN and ZDHHC1 in fish cells. Similarly, knockdown of STING resulted in inhibition of the IFN promoter. In contrast, ZDHHC1 knockdown also inhibited IFN expression but had no apparent effect on STING, which indicates that STING is necessary for IFN activation through ZDHHC1. In conclusion, STING and ZDHHC1 in fish can respond to viral DNA or RNA molecules in cytoplasm, as well as activate IRF3 and, eventually, trigger IFN expression.
Cellular Immune Responses to Neisseria meningitidis in Children

ABSTRACT There is an urgent need for effective vaccines against serogroup BNeisseria meningitidis. Current experimental vaccines based on the outer membrane proteins (OMPs) of this organism provide a measure of protection in older children but have been ineffective in infants. We postulated that the inability of OMP vaccines to protect infants might be due to age-dependent defects in cellular immunity. We measured proliferation and in vitro production of gamma interferon (IFN-γ), tumor necrosis factor alpha, and interleukin-10 (IL-10) in response to meningococcal antigens by peripheral blood mononuclear cells (PBMCs) from children convalescing from meningococcal disease and from controls. After meningococcal infection, the balance of cytokine production by PBMCs from the youngest children was skewed towards a TH1 response (low IL-10/IFN-γ ratio), while older children produced more TH2 cytokine (higher IL-10/IFN-γ ratio). There was a trend to higher proliferative responses by PBMCs from older children. These responses were not influenced by the presence or subtype of class 1 (PorA) OMP or by the presence of class 2/3 (PorB) or class 4 OMP. Even young infants might be expected to develop adequate cellular immune responses to serogroup B N. meningitidis vaccines if a vaccine preparation can be formulated to mimic the immune stimulus of invasive disease, which may include stimulation of TH2 cytokine production.
Mutations That Rescue the Paralysis of Caenorhabditis elegans ric-8 (Synembryn) Mutants Activate the Gαs Pathway and Define a Third Major Branch of the Synaptic Signaling Network

To identify hypothesized missing components of the synaptic Gαo-Gαq signaling network, which tightly regulates neurotransmitter release, we undertook two large forward genetic screens in the model organism C. elegans and focused first on mutations that strongly rescue the paralysis of ric-8(md303) reduction-of-function mutants, previously shown to be defective in Gαq pathway activation. Through high-resolution mapping followed by sequence analysis, we show that these mutations affect four genes. Two activate the Gαq pathway through gain-of-function mutations in Gαq; however, all of the remaining mutations activate components of the Gαs pathway, including Gαs, adenylyl cyclase, and protein kinase A. Pharmacological assays suggest that the Gαs pathway-activating mutations increase steady-state neurotransmitter release, and the strongly impaired neurotransmitter release of ric-8(md303) mutants is rescued to greater than wild-type levels by the strongest Gαs pathway activating mutations. Using transgene induction studies, we show that activating the Gαs pathway in adult animals rapidly induces hyperactive locomotion and rapidly rescues the paralysis of the ric-8 mutant. Using cell-specific promoters we show that neuronal, but not muscle, Gαs pathway activation is sufficient to rescue ric-8(md303)'s paralysis. Our results appear to link RIC-8 (synembryn) and a third major Gα pathway, the Gαs pathway, with the previously discovered Gαo and Gαq pathways of the synaptic signaling network.
Lineage-Specific Transcription Factors in Multipotent Hematopoietic Progenitors: A Little Bit Goes a Long Way

Basal expression of lineage-specific transcription factors (TFs) in multipotent hematopoietic progenitor cells (HPCs) plays a pivotal role in normal hematopoiesis. Indeed, the interplay between lineage-specific TFs and chromatin modifying or remodeling complexes allows chromatin modifications at specific hematopoietic loci and promotes transcriptionally prone conformations. It is now well accepted that during hematopoiesis, the expression of various lineage-specific genes can be preceded by their potentiation i.e., by chromatin activation, in progenitor cells. Gene potentiation appears to counterbalance epigenetic silencing of lineage-specific genes in early progenitors, while maintaining an accessible chromatin conformation in the lineage pathway selected. Herein, we discuss the impact of lineage-specific TFs on gene potentiation and priming in normal hematopoiesis, and emphasize the complementary role of locus control region (LCR) or LCR-like structures and promoter regions in gene-specific potentiation events.
Biology of Cancellous Bone Graft Materials and their Usage for Bone Regeneration

Bone grafting have been used to treat nonunion, union and acute fractures. Autologous cancellous bone grafts are still the most effective graft material for stimulating bone repair since they present osteoconduction, osteoinduction and osteogenic capacity that are mainly requirements for bone regeneration. However, there are several negative aspects of autologous cancellous grafts such as additional surgical site, post-operative complications and inadequate amount of grafts. Allogeneic cancellous bone grafts, on the other hand, have the same characteristics as cancellous autograft with the exclusion of osteogenic capacity. Understanding of various biological processes such as host mediated immune response, osteo-integration of the graft within host and new bone re-modelling leads to improve the new biological strategies for endosseous grafts. We’ll discuss the biology of the cancellous bone graft which is essential to understand host-graft incorporate and also evaluate the specific factors associated with the osseous healing around the graft.
Aspectos gerenciais e infra-estrutura em criações de caprinos e ovinos na região semiárida da Paraíba

Com objetivo de identificar as caracteristicas relacionadas com os sistemas de criacao caprina e ovina na Microrregiao de Patos - PB foram analisadas 90 propriedades de nove municipios pertencentes a Microrregiao, localizada na regiao do Sertao do Estado da Paraiba, nas quais foram aplicados questionarios visando obter informacoes relacionadas aos sistemas de criacao caprina e ovina, envolvendo aspectos de infraestrutura das propriedades, escolaridade dos proprietarios e nivel de organizacao. Os resultados mostram que esta atividade e realizada de forma extensiva apresentando dificuldades nos aspectos gerencias, alto indice de analfabetismo dos proprietarios e assistencia tecnica deficiente.
American Urogynecologic Society Best-Practice Statement: Recurrent Urinary Tract Infection in Adult Women.

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The Circadian Clock Modulates Global Daily Cycles of mRNA Ribosome Loading[OPEN]

Measurements of mRNA ribosome loading in wild-type and clock-deficient plants show that the circadian clock regulates the translation of Arabidopsis mRNAs in concert with diurnal light-dark changes. Circadian control of gene expression is well characterized at the transcriptional level, but little is known about diel or circadian control of translation. Genome-wide translation state profiling of mRNAs in Arabidopsis thaliana seedlings grown in long day was performed to estimate ribosome loading per mRNA. The experiments revealed extensive translational regulation of key biological processes. Notably, translation of mRNAs for ribosomal proteins and mitochondrial respiration peaked at night. Central clock mRNAs are among those subject to fluctuations in ribosome loading. There was no consistent phase relationship between peak translation states and peak transcript levels. The overlay of distinct transcriptional and translational cycles can be expected to alter the waveform of the protein synthesis rate. Plants that constitutively overexpress the clock gene CCA1 showed phase shifts in peak translation, with a 6-h delay from midnight to dawn or from noon to evening being particularly common. Moreover, cycles of ribosome loading that were detected under continuous light in the wild type collapsed in the CCA1 overexpressor. Finally, at the transcript level, the CCA1-ox strain adopted a global pattern of transcript abundance that was broadly correlated with the light-dark environment. Altogether, these data demonstrate that gene-specific diel cycles of ribosome loading are controlled in part by the circadian clock.
Analyzing Finger-Movement Trajectories with Stochastic Differential Equations ( SDEs )

Fingertip positions can be conceptualized as Brownian particles within a force field. Using stochastic differential equations (SDEs) the force field and its associated potential function can be formally related to observed fingertip positions. Using observed fingertip positions the force field can then be “solved. ” This provides a means of describing, comparing, and simulating finger-movement trajectories without formulating the kinematics of the hand. Through discretization of SDEs, the resulting mathematical forms are merely regression equations, which can be solved using familiar mathematical tools such as ordinary least squares and maximum likelihood estimation. Experimental “effects” are specified in the force-field part of the regression, and the Brownian perturbances as the random error of the regression. Using SDEs to specify potential functions can support haptic scientists performing exploratory data analysis, wishing to summarize finger-movement trajectories, compare and test differences in finger-movement trajectories between participants, groups of participants, or experimental conditions, and simulate/predict finger-movement trajectories.