Miracle-dz/UniFAR-FTUs huggingface dataset:
The accuracy of head and neck carcinoma sentinel lymph node biopsy in the clinically N0 neck

Sentinel lymph node (SLN) biopsy originally was described as a means of identifying lymph node metastases in malignant melanoma and breast carcinoma. The use of SLN biopsy in patients with oral and oropharyngeal squamous cell carcinoma and clinically N0 necks was investigated to determine whether the pathology of the SLN reflected that of the neck.
CLARITY about the use of clopidogrel in patients with acute coronary syndromes and myocardial infarction

Clopidogrel was shown to have added benefits to aspirin in patients with acute coronary syndromes without ST-segment elevation in the Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) trial. The cost in CURE was estimated to be US$442 greater in the clopidogrel group and the incremental cost-effectiveness ratio (incremental cost/life-year gained) was US$6318. Clopidogrel has also recently been shown to have added benefits to aspirin in patients with myocardial infarction with ST-segment elevation in the Clopidogrel as Adjunctive Reperfusion Therapy (CLARITY) – Thrombolysis in Myocardial Infarction (TIMI) 28 study. The primary efficacy composite end point in CLARITY was an occluded infarct-related artery, death from any cause prior to angiography, or recurrent myocardial infarction, and this end point occurred less in the clopidogrel group (15%, 262 of 1752 patients) than placebo group (21.7%, 377 of 1739 patients). This difference was predominantly due to a reduction in the occluded infarct-related artery, which occurred in less of the clopidogrel (11.7%) than placebo group (18.4%). There was also a reduction in urgent revascularisations in the clopidogrel group of CLARITY. Thus, clopidogrel is effective and cost effective in acute coronary syndromes, and is also beneficial in patients with myocardial infarction with ST-segment elevation.
Cold Tolerance and Overwintering of the Diamondback Moth (Lepidoptera: Plutellidae) in Southeastern Australia

ABSTRACT Southeastern Australia is situated in a temperate zone with generally mild winters. The diamondback moth, Plutella xylostella L. , can be a serious pest of canola as well as of other Brassica crops in this region. However, the ability of P. xylostella to overwinter in southeastern Australia, as well as in other temperate regions of the world, remains controversial. Laboratory experiments indicated that after 60 d in a temperature regimen alternating between 0 and 5°C, 32% of third- and fourth-instar larvae pupated, 38% remained as larvae, and 57% of pupae survived, whereas only 15–20% of adult moths were still alive. Second-, third-, and fourth-instar larvae and pupae survived -5°C for up to 2, 4, 6, and 13 d, respectively, with some adults surviving >20 d. Furthermore, adults that survived 60 d of exposure to 0–5°C and 20 d at -5°C reproduced normally without supplemental food. An experiment simulating outdoor overwintering with caged populations and field survey for natural overwintering populations of P. xylostella on volunteer canola (Brassica napus L.) and wild turnip (Rapistrum rugosum L.) plants indicated that development and reproduction continued on these host plants through the winter months. These empirical results provide evidence that P. xylostella is capable of overwintering on suitable host plants in southeastern Australia, and the overwintering populations may contribute significantly to local population levels in spring and summer seasons.
The development of management system for Building Equipment Internet of Things

Building Equipment Internet of Things is a network which can connect all kinds of equipment in buildings together. This paper develops a management system for Building Equipment Internet of Things, which not only can acquire equipment operation parameters, environmental data and person location infomation, but also can publish these data to the Internet. The architecture of this system and some important modules in it are introduced in detail, including the flow of the Communication Service Module, the data structures of the real-time database, the frames of three important tables in Database. Compared to the traditional Building Automation Systems, this system can make it possible for people to access the data of equipment, environment as well as person position through the Internet, and control every device by any remote computer's Web browser. Moreover, our system can realize both the multi-objective optimization energy saving control and the fault diagnosis of equipment based on the data above. Finally, if added in it the functions of energy consumption collecting and monitoring as well as the functions of building power quality monitoring, this system can be expanded easily to a comprehensive building equipment and energy management system based on Internet of Things.
Breaking Bad in Bourbon Country: Does Alcohol Prohibition Encourage Methamphetamine Production?

This paper examines the influence of local alcohol prohibition on the prevalence of methamphetamine labs. Using multiple sources of data for counties in Kentucky, we compare various measures of meth manufacturing in wet, moist, and dry counties. Our preferred estimates address the endogeneity of local alcohol policies by using as instrumental variables data on religious affiliations in the 1930s, when most local-option votes took place. Alcohol prohibition status is influenced by the percentage of the population that is Baptist, consistent with the “bootleggers and Baptists” model. Our results suggest that the number of meth lab seizures in Kentucky would decrease by 24.4 percent if all counties became wet.
The Importance of Debriefing in Simulation-Based Learning: Comparison Between Debriefing and No Debriefing

Debriefing is an essential component of simulation-based learning and is a constructive teaching strategy for teachers and an effective learning method to consolidate knowledge and skills for students. The purpose of this study was to verify the importance of debriefing in simulation-based learning for students in a nursing program. Participants in this study were 49 second-year nursing students who were enrolled at the Red Cross College of Nursing in Seoul, Korea. Collected data were analyzed using &khgr;2 test, t test, and independent t test statistics. There were significant differences between students in the debriefing group and those in the no-debriefing group evaluated. The level of clinical performance competency, self-reflection, and satisfaction with simulation-based learning for debriefing group students was higher than that for no-debriefing group. Debriefing was an important factor in simulation-based learning to improve technical and nontechnical skills and facilitate self-reflection. These results suggest that debriefing by a trained instructor is essential for maximizing simulation-based learning success. In absence of a trained debriefing instructor, various alternative forms of debriefing should be considered.
A dose-escalation study of tositumomab and iodine I 131 tositumomab (Bexxar) in pts with previously treated non-Hodgkin's lymphoma (NHL) with > 25% bone marrow involvement.

6575 Introduction: The Bexxar therapeutic regimen can produce durable and complete responses in patients with relapsed/refractory low-grade NHL. Virtually all previous studies of radioimmunotherapeutic agents (including Bexxar therapy) for NHL excluded patients with extensive bone marrow involvement (BMI) with tumor (>25% intertrabecular space) due to risk of excess hematologic toxicity. Therefore, we evaluated Bexxar therapy specifically in this patient population to assess safety and toxicity in a dose-escalation study. METHODS Subjects were required to have baseline BMI of >25% and platelet count of 150,000/mm3. A patient-specific dose of Iodine 131 Tositumomab was administered to deliver a defined amount of total body radiation. Dose escalation began at a total body dose of 45 cGy (subsequently increased in increments of 10 cGy). Dose limiting toxicity (DLT) was defined as ANC < 500/mm3 or platelets <25,000/mm3 for >17 d; or ANC <750/mm3 or platelets <50,000/mm3 for >24 d. RESULTS Eleven patients were enrolled (8 at 45 cGy and 3 at 55 cGy). Estimated BMI was 30% to 65%, with median of approx 40%. Subjects had a median of 3 prior chemotherapies (range: 1-6). One of 6 evaluable patients treated at 45 cGy experienced hematologic DLT. Three patients (estimated BMI 40-60%) received 55 cGy, with 1 having hematologic DLT concurrent with lymphoma progression with extensive BMI. Three of 11 (27%) subjects received hematologic supportive care. Non-hematologic toxicities were minimal and were similar to previous studies. Two patients responded with durations of 1 and 43.6+ months. CONCLUSION Treatment of patients with >25 % bone marrow involvement with Bexxar therapy was well tolerated at 45 cGy total body dose and can result in lymphoma responses. Further studies with additional patients and at higher doses are required to further characterize the MTD and to establish efficacy. [Table: see text].
Force interaction and 3D pole movement in double poling

The aim of this study was to analyze double poling using combined kinetic and 3D kinematic analysis at high skiing speeds as regards pole force components, pole angles and pole behavior during the poling and swing phase. The hypothesis was that a horizontal pole force is more predictive for maximal skiing speed (Vmax) than the resultant pole force. Sixteen elite skiers performed a double‐poling Vmax test while treadmill roller skiing. Pole forces and 3D kinematics of pole movement at a speed of 30 km/h were analyzed and related to Vmax. The duration of the “preparation phase” showed the strongest relationship with Vmax (r=0.87, P<0.001). Faster skiers generated longer cycle lengths with longer swing and poling times, had less inclined pole angles at pole plant and a later peak pole force. Horizontal pole forces were not more highly related to Vmax compared with the resultant pole force. Impact force was not related to Vmax. At high skiing speeds, skiers should aim to combine high pole forces with appropriate timing of pole forces and appropriate pole and body positions during the swing and poling phase. The emphasis in training should be on the development of specific strength capacities for pole force production and the utilization of these capacities in double‐poling training sessions.
Multicenter Crossover Study of Automated Control of Inspired Oxygen in Ventilated Preterm Infants

OBJECTIVE: To determine the efficacy and safety of automated adjustment of the fraction of inspired oxygen (Fio2) adjustment in maintaining arterial oxygen saturation (Spo2) within an intended range for mechanically ventilated preterm infants with frequent episodes of decreased Spo2. METHODS: Thirty-two infants (gestational age [median and interquartile range]: 25 weeks [24–27 weeks]; age: 27 days [17–36 days]) were studied during 2 consecutive 24-hour periods, one with Fio2 adjusted by clinical staff members (manual) and the other by an automated system (automated), in random sequence. RESULTS: Time with Spo2 within the intended range (87%–93%) increased significantly during the automated period, compared with the manual period (40% ± 14% vs 32% ± 13% [mean ± SD]). Times with Spo2 of >93% or >98% were significantly reduced during the automated period (21% ± 20% vs 37% ± 12% and 0.7% vs 5.6% [interquartile ranges: 0.1%–7.2% and 2.7%–11.2%], respectively). Time with Spo2 of <87% increased significantly during the automated period (32% ± 12% vs 23% ± 9%), with more-frequent episodes with Spo2 between 80% and 86%, whereas times with Spo2 of <80% or <75% did not differ between periods. Hourly median Fio2 values throughout the automated period were lower and there were substantially fewer manual Fio2 changes (10 ± 9 vs 112 ± 59 changes per 24 hours; P < .001), compared with the manual period. CONCLUSIONS: In infants with fluctuations in Spo2, automated Fio2 adjustment improved maintenance of the intended Spo2 range led to reduced time with high Spo2 and more-frequent episodes with Spo2 between 80% and 86%.
Industrial Zones in Modern Cities: a Source of Socio-Ecological Inequality or an Opportunity for Prosperity?

In this article examines the interrelation between the processes of industrialization and urbanization in terms of their impact on the quality of life in cities. The modern city is largely the result of the accelerated development of industry in the XIX - early XX centuries, however, the transition to the postindustrial phase of the development of society, which begins in the second half of the XX century, leads to deindustrialization of urban development. One of the trends of modern urban planning is the reconstruction of industrial zones which is carried out in the form of their adaptive reuse, which avoids many of the costs associated with their radical restructuring, although such a path is not always possible. According to opinions of the authors, the appeal to the idea of adaptive reuse becomes one of the means of revitalizing the urban landscape and, as a result, urban life.
Rheumatoid arthritis patients' knowledge of the disease and its treatments: a descriptive study.

OBJECTIVE The purpose of rheumatoid arthritis (RA) patient education is to increase patients' knowledge levels. However, there are only a limited number of studies available concerning these patients' knowledge of their disease and its various treatments. The purpose of this study was to describe RA patients' understanding of their disease and its treatments. METHODS A total of 252 RA patients participated in this survey in August 2004 (response rate 53.2%). The knowledge levels of the patients and their physical functioning were measured using self-reported questionnaires. The data were analysed using descriptive and non-parametric statistical methods. RESULTS RA patients' knowledge of the disease and its treatments was, on average, good. However, the total scores of the Patient Knowledge Questionnaire ranged from 2 to 29 (maximum score 30). The patients knew well the aetiology and symptoms of RA, the blood tests and the physical exercise; they knew moderately well the facts relating to joint protection, energy conservation and how to use anti-rheumatic drugs and non-steroidal anti-inflammatory drugs. Young patients, women and patients with a long disease duration knew the most. There was a weak correlation between patient knowledge and physical functioning: the weaker the patient's functioning, the higher the knowledge level. CONCLUSIONS RA patients' knowledge of their disease and its treatments varied from poor to good in this group. These results can be used for advancing RA patient education. However, more research is needed to evaluate RA patients' knowledge levels.
Tourist motivations for visiting heritage attractions: new insights from a large US study

This article describes the results of a large study measuring tourist motivations for visiting heritage-related attractions in a major state in the US. The study used a quantitative survey method with a sample size of more than 3,500 collected at dozens of diverse heritage tourism attractions in a geography spanning hundreds of miles. The methodology used a blended paper and online technique using QR image technology to assist respondents in completing surveys on any mobile device. The study also used GIS software to map survey data points. 'Seeing heritage attractions' was the top motivation cited by respondents for their visit (39%) followed by 'outdoor recreation' (22%), 'visiting friends and family' (13%) and 'just passing through' (8%). Eighteen percent of visitors reported that they visited because the lived nearby. Conclusions and limitations of the study as well as implications for future research are also discussed.
Biliary liver flukes (Opisthorchiasis and Clonorchiasis) in immigrants in the United States: often subtle and diagnosed years after arrival.

BACKGROUND Biliary liver flukes are extremely common parasites in some regions of the world where consumption of raw fresh-water fish is a cultural practice. Clonorchis sinensis and Opisthorchis spp. are the major biliary liver flukes associated with human disease. Some of these parasites are highly associated with cholangiocarcinoma. It was noted that several cases presenting at our center had been in the US for prolonged periods. This prompted us to retrospectively review cases of liver fluke infection diagnosed at our facility. METHODS All cases of biliary liver fluke infection over a 6-year period were retrospectively investigated at a clinic serving international patients, to determine the prevalence and risk factors for infection in a nonendemic area. Cases were identified through review of stool ova and parasite (O&P) records maintained at Regions Hospital/HealthPartners microbiology laboratory. All O&P samples positive for Opisthorchis spp. or Clonorchis sinensis were included in the review. RESULTS Seventeen cases were identified during the study period. Our center performed approximately 1,800 stool O&P examinations per year on approximately 1,100 individuals per year during the study period. Biliary liver flukes were uncommon, accounting for 1.3% of individuals infected with organisms considered to be potentially pathogenic. Infections were predominantly found in migrants from Laos, Cambodia and Thailand. Cases were also identified in migrants from the former Soviet Union and South America. It is of note that 25% of patients were detected after 5 years of residence in the US. Often, the only clinical clue to infection was a mild absolute eosinophilia (500 to 1000 microL). CONCLUSIONS Although biliary liver fluke is an infrequent cause of infection in immigrants to the US, because of the potential long-term consequences of chronic infection, educational information highlighting routes of infection and the fact that asymptomatic infection is common and may eventually lead to cancer should be aimed at high-risk community members and those who have been visiting friends and relatives in endemic areas.
Prospective Trial in Saudi Arabia Comparing the 14-day Standard Triple Therapy with the 10-day Sequential Therapy for Treatment of Helicobacter Pylori Infection

Background/Aims: Treatment success for Helicobacter pylori infection in Saudi Arabia is relatively unexplored. This prospective study compared the efficacy of sequential versus standard triple therapy in curing H. pylori infections. Patients and Methods Eligible patients underwent upper endoscopy at a single center in Saudi Arabia from October 2011 to February 2014. Patients who tested positive for H. pylori infection were randomly assigned to sequential therapy or standard triple therapy. Sequential treatment: Esomeprazole (20 mg bid for 10 days), amoxicillin (1000 mg for 5 days), then clarithromycin 500 mg and tinidazole 500 mg; both bid for 5 days. Standard triple treatment: Esomeprazole 20 mg, clarithromycin 500 mg, and amoxicillin 1000 mg each bid for 14 days. After 6 weeks of treatment, patients were tested for cure using a validated urea breath test. Application of the E-test determined susceptibility of H. pylori to different antibiotics. Results: Of the 115 patients who received sequential therapy, 93 completed treatment. In the triple-therapy arm, 103 of 117 patients completed treatment. The eradication rate was 58/93 (62.3%) with sequential therapy and 69/102 (67.6%) with standard triple therapy, P = 0.44. Risk ratio was 0.92 (95% CI; 0.75–1.13), and number needed to treat was 19. Overall primary resistance: Metronidazole (48.5%), clarithromycin (23.3%), amoxicillin (14.8%), levofloxacin (11.1%), and tetracycline (2.3%). Mild adverse events occurred in 35 and 17 patients in the sequential and standard therapy groups, respectively. Conclusion: Sequential and standard triple therapies were similarly effective at eradicating H. pylori in two-thirds of Saudi patients. Metronidazole and clarithromycin resistance to H. pylori strains was common.
One Man’s Trash is Another Man’s Treasure: How the Circular Economy Contributes to Achieving SDGs -The Case of Used Tires in Spain

During the end of the 20th century and beginning of 21st century, there is a trend to evaluating the actions undertaken to improve the socio-economic environment in which we live, to achieve a greater level of wellbeing for all citizens. In the context of Stakeholder Theory, considering an organization should always operate towards creating positive value for society, the creation of the UN Global Compact and the 17 Sustainable Development Goals created a shift in many regions. The present study evaluates this context and how the implementation of circular economy policies has affected the achievement of SDGs in Spain. Specifically, the role of different private and public agents is evaluated in the tire manufacturing industry and the impact in each of the SDGs. Results show positive results as well as areas of improvement to further improve the roadmap towards achieving the 17 SDGs.
Finance and the Reallocation of Scientific, Engineering and Mathematical Talent

The US financial sector has become a magnet for the brightest graduates in the science, technology, engineering and mathematical fields (STEM). We provide quantitative bases for this well-known fact and illustrate its consequences for the productivity growth in other sectors over the period 1980-2014. First, we find that the share of STEM talents grew significantly faster in finance than in other key STEM sectors such as high-tech, and this divergent pattern has been more evident for STEM than for general skills and more pronounced for investment banking. Second, this trend did not reverse after the Great Recession, and a persistent wage premium is found for STEM graduates working in finance and especially in typical financial jobs at the top of the wage distribution. Third, the brain drain of STEM talents into finance has been associated with a cumulative loss of labor productivity growth of 6.6% in the manufacturing sectors. Our results suggest that increasing the number of STEM graduates may not be enough to reignite sluggish economic growth without making their employment in finance more costly.
MRAS-based adaptive speed estimator in PMSM drives

The permanent magnet synchronous motor (PMSM) is increasingly playing an important role in advanced motor drives. An encoder or resolver attached to the shaft of the motor typically supplies the feedbacks required for PMSM torque and speed control. Many advanced motor drives can not tolerate the use of these feedback devices because of reliability concerns in a harsh environment, price, space and weight limitations. In this paper MRAS-based adaptive strategy has been used for speed estimation. In compare to previously developed methods in the literature such as: EKF, sliding mode control, Hinfin control, this method consumes less computational time and it is easy to implement in microcontrollers and DSP. In this proposed method the Popov's criterion is used for adaptive speed estimation. The Popov's criterion is easier than Lyapunov criterion since it does not need for any predetermined function as it is necessary for Lyapunov criterion. The validity of the MRASbased adaptive strategy has been verified by simulation and experiments