Miracle-dz/UniFAR-FTUs huggingface dataset:
An Update on Protein, Leucine, Omega-3 Fatty Acids, and Vitamin D in the Prevention and Treatment of Sarcopenia and Functional Decline

Aging is associated with sarcopenia and functional decline, leading to frailty and disability. As a modifiable risk factor, nutrition may represent a target for preventing or postponing the onset of these geriatric conditions. Among nutrients, high-quality protein, leucine, vitamin D, and omega-3 polyunsaturated fatty acids (n-3 PUFA) are of particular interest for their demonstrated effects on skeletal muscle health. This narrative review aims to examine the recent observational and interventional evidence on the associations and the role of these nutrients in the muscle mass, strength, mobility, and physical function of free-living older adults, who are either healthy or at risk of frailty. Recent evidence supports a higher protein intake recommendation of 1.0–1.2 g/kg/day in healthy older adults; an evenly distributed mealtime protein intake or minimal protein per meal may be beneficial. In addition, vitamin D supplementation of 800–1000 IU, particularly when vitamin D status is low, and doses of ~3 g/day of n-3 PUFA may be favorable for physical function, muscle mass, and strength. Reviewed studies are highly heterogenous, yet the quantity, quality, and timing of intakes should be considered when designing intervention studies. Combined protein, leucine, vitamin D, and n-3 PUFA supplements may convey added benefits and may represent an intervention strategy in the prevention of sarcopenia and functional decline.
Classification and Structural Evaluation of Fully-Actuated Hexrotor UAVs

This paper presents a kind of taxonomy to classify and understand the acceleration characteristics of fully-actuated hexrotor unmanned aerial vehicles. First, two special classes of hexrotor structures are defined: symmetric-coplanar-tilted-rotor (SCTR) structure and parallel-coplanar-tilted-rotor (PCTR) structure. It is shown that many of structures from related research can be classified into the two types. Moreover, the acceleration characteristics of hexrotor structures can be analyzed and visualized using dynamic manipulability. The dynamic manipulability ellipsoids enable to evaluate the directional characteristics of the vehicle motion, and it is suited to the design of the fully-actuated hexrotor for each aerial manipulation task.
Assessing the Efficacy of Lopinavir/Ritonavir-Based Preferred and Alternative Second-Line Regimens in HIV-Infected Patients: A Meta-Analysis of Key Evidence to Support WHO Recommendations

Background: Nucleoside reverse transcriptase inhibitors (NRTIs) and non-NRTIs (NNRTIs) with boosted protease inhibitors are included in standardized first-line and second-line regimens. Recent World Health Organization (WHO) guidelines recommend a boosted protease inhibitor (PI) combined with 2 NRTIs or raltegravir as a second-line regimen. Objective: Ritonavir-boosted lopinavir (LPV/r) is known as a key second-line antiretroviral therapy (ART) in resource-limited settings. We carried out a meta-analysis to analyze virologic suppression and effectiveness of LPV/r-based second-line therapy in HIV-infected patients. Methods: In this meta-analysis, we searched randomized controlled trials and observational cohort studies to evaluate outcomes of second-line ART for patients with HIV who failed first-line therapy. A systematic search was conducted in Pubmed, Cochrane Library, and Embase from inception to January 2018. Outcomes included viral suppression, CD4 cell counts, drug resistance, adverse events, and self-reported adherence. We assessed comparative efficacy and safety in a meta-analysis. Data analysis was performed using RevMan 5.3 and Stata12.0. Results: Nine studies comprising 3,923 patients were included in the meta-analysis. The overall successful virologic suppression rate of the second-line regimen was 77% (ITT) and 87% (PP) at 48 weeks with a plasma HIV RNA load of <400 copies/mL. No statistical significance was found in CD4 cell count recoveries between LPV/r plus 2-3 NRTIs and simplified regimens (LPV/r plus raltegravir) at 48 weeks (P = 0.09), 96 weeks (P = 0.05), and 144 weeks (P = 0.73). Four studies indicated that the virus had low-level resistance to LPV/r, and the most common clinically significant PI-resistance mutations were 46I, 54V, 82A/82F, and 76V; however, no virologic failure due to LPV/r resistance was detected. In addition, no statistical significance was found between the two groups in self-reported adherence [relative risks (RR) = 1.03,95% confidence interval (CI) 1.00, 1.07, P = 0.06], grade 3 or 4 adverse events (RR = 0.84, 95% CI 0.64, 1.10, P = 0.20) or serious events (RR = 0.85, 95% CI 0.77, 1.17, P = 0.62). Conclusions: These results suggest that the LPV/r-based regimen demonstrates efficacious and low resistance as second-line antiretroviral therapy.Both LPV/r plus 2-3 NRTIs and LPV/r plus RAL regimens improved CD4 cell counts. There was no evidence of superiority of simplified regimens over LPV/r plus 2-3 NRTIs.
Robust 3-D Human Detection in Complex Environments With a Depth Camera

Human detection has received great attention during the past few decades, which is yet still a challenging problem. In this paper, we focus on the problem of 3-D human detection, i.e., finding the human bodies and determining their 3-D coordinates in complex 3-D space using depth data only. Since the traditional sliding-window-based approaches for target localization are time-consuming and the recent deep-learning-based object detectors generate too many region proposals, we propose to utilize the candidate head-top locating stage to efficiently and quickly find the plausible head-top locations. In the second stage, we propose a Depth map, Multiorder depth template, and Height difference map representation encoding three channels of information for each candidate region to utilize the neural network pretrained on large-scale well-annotated datasets to classify the candidate regions. We evaluate our method on four publicly available challenging datasets. Extensive experimental results demonstrate that the proposed method is superior to the state-of-the-art methods while achieving real-time performance.
Efficient Parallel K Best Connected Trajectory (K-BCT) Query with GPGPU: A Combinatorial Min-Distance and Progressive Bounding Box Approach

Performing similarity analysis on trajectories consisting of massive numbers of tracking points is computationally challenging. We introduce a progressive minimum bounding rectangle (MBR) and minimum distance (MINDIST) approach to process the K Best Connected Trajectory (K-BCT) query, which aims to find the top K similarity trajectories to a given query trajectory. Our approach has three unique features to speed up the query. First, the approach builds a series of progressive MBRs from the query trajectory to determine the order of reference trajectories to identify the target top K reference trajectories at an earlier stage. Second, this method introduces a grid-based search method to speed up the matched point detection between two trajectories for similarity measures. Third, this approach further leverages the many-core computing power of Graphical Processing Unit (GPU) devices to perform the query in a parallel manner. We have conducted tests with ship tracking data and human movement data using GPU instances from Amazon Web Services. Preliminary results indicate that (a) parallel computing has greatly improved the efficiency of the query, and (b) our optimized approach can further speedup the computation compared to parallel implementations.
Using Probes for Sharing (Tacit) Knowing in Participatory Design: Facilitating Perspective Making and Perspective Taking

Abstract The sharing of expertise and tacit knowing is one of the core objectives in participatory design projects. This paper focuses on the role of probes for sharing users’ tacit knowing. We will introduce the concept of “boundary objects” [22], [21] to analyse how probes facilitate perspective taking and perspective making between users and between users and researchers. In so doing, we demonstrate that probes can facilitate the sharing of users’ tacit knowing and expertise (i) by making and explicating individual users’ perspectives, (ii) by enabling participants to take each other’s perspective and make a joint perspective and (iii) by subsequently enabling the making of a joint vision on the digital design outcome. The research presented in this paper is based on an EU-funded research and innovation project in which we co-created digital neighbourhood guide with older adults. We report from our fieldwork in city 1, where we used probes as part of our participatory design practice.
Impact of neoadjuvant therapy on postoperative outcomes after pancreaticoduodenectomy

Surgical resection provides the only potentially curative treatment of pancreatic cancer. Neoadjuvant chemotherapy and/or radiation (NAT) is used to downstage patients with borderline resectable tumors. The objective of this study was to examine the postoperative morbidity and mortality of NAT after pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDA).
Commentary: The Invention of Aboriginal Diabetes: The Role of the Thrifty Gene Hypothesis in Canadian Health Care Provision.

The purpose of this study was to analyze the extent to which the 'thrifty gene hypothesis' remains embedded within regimes of Canadian health care. The thrifty gene hypothesis, formulated by the American geneticist and travelling scientist James V. Neel in 1962, proposed that Indigenous peoples were genetically predisposed to Type 2 diabetes due to the foodways of their ancestors. The hypothesis was functionally racist and based on what biological anthropologists now call 'the myth of forager food insecurity. ' Importantly, Neel reconsidered his own hypothesis in 1982 before he ultimately rejected it in 1999; nonetheless, in the mid-1990s, a team of Canadian scientists led by the endocrinologist Robert Hegele of Western University conducted a genetic study on the OjiCree community of Sandy Lake First Nation in northern Ontario. Thereafter, Hegele told the academic world and news media that he had discovered a thrifty gene in Sandy Lake. Like Neel, Hegele later came to reject his own study in 2011. Nonetheless, the 'thrifty gene hypothesis' and Hegele's Sandy Lake study continue to be cited, referenced, and reproduced in the current Clinical Guidelines of the Canadian Diabetes Association, as well as across state-related health literature more broadly. The purpose of this study, then, will be to apply the PHCRP to the thrifty gene hypothesis in a Canadian context.
High-Throughput Screening of Entamoeba Identifies Compounds Which Target Both Life Cycle Stages and Which Are Effective Against Metronidazole Resistant Parasites

Neglected tropical diseases, especially those caused by parasites, are significantly underserved by current drug development efforts, mostly due to the high costs and low economic returns. One method for lowering the costs of drug discovery and development for these diseases is to repurpose drugs developed for other indications. Here, we present the results of a screen of five repurposed drug libraries to identify potential new lead compounds to treat amebiasis, a disease that affects tens of millions of people and causes ~100,000 deaths annually. E. histolytica, the causative agent of amebiasis, has two major life cycle stages, the trophozoite and the cyst. The current primary treatment for amebiasis, nitroimidazole compounds, do not eliminate parasites from the colonic lumen, necessitating a multi-drug treatment regimen. We aimed to address this problem by screening against both life stages, with the aim of identifying a single drug that targets both. We successfully identified eleven compounds with activity against both cysts and trophozoites, as well as multiple compounds that killed trophozoites with improved efficacy over existing drugs. Two lead compounds (anisomycin and prodigiosin) were further characterized for activity against metronidazole (MNZ) resistant parasites and mature cysts. Anisomycin and prodigiosin were both able to kill MNZ resistant parasites while prodigiosin and its analog obatoclax were active against mature cysts. This work confirms the feasibility of identifying drugs that target both Entamoeba trophozoites and cysts, and is an important step toward developing improved treatment regimens for Entamoeba infection.
Design Space Exploration for Powertrain Electrification using Gaussian Processes

Design space exploration of hybrid electric vehicles is an important multi-objective global optimization problem. One of the main objectives is to minimize fuel consumption while maintaining satisfactory driveability performance and vehicle cost. The design problem often includes multiple design options, including different driveline architectures and component sizes, where different candidates have various trade-offs between different, in many cases contradictory, performance requirements. Thus, there is no global optimum but a set of Pareto-optimal solutions to be explored. The objective functions can be expensive to evaluate, due to time-consuming simulations, which requires careful selection of which candidates to evaluate. A design space exploration algorithm is proposed for finding the set of Pareto-optimal solutions when the design search space includes multiple design options. As a case study, powertrain optimization is performed for a medium-sized series hybrid electric delivery truck.
Dynamic Programming Approach of Optimal Upgradation Algorithm for an Auxiliary Random Variable of a Bernoulli Random Variable

This study considers a problem of finding an optimal approximation of conditional information measures, like the conditional entropy, of a Bernoulli random variable (RV) given an auxiliary RV. We define an optimality of the problem in terms of the data-processing lemma of conditional information measures; and the problem aims to create an optimal auxiliary RV through partial orders of auxiliary RVs for a given RV. We describe an optimal upgradation algorithm by dynamic programming. Proving a Monge property of the dynamic programming, we describe speeding-up method of the algorithm by applying SMAWK algorithm.
Radiation Pattern of Ultrasonic Transducer with Polymer-Powder Matching Layer

The work is devoted to the study of the radiation pattern of the ultrasonic transducers. Transducers modified by deposition in the electrostatic field of a protective matching quarter-wave polymer-powder layer. It is shown that the use of the matching layer does not significantly change the radiation pattern of the transducers. The presented results show the dependence of the radiation pattern on the frequency. It is shown that the width of the main lobe of the radiation pattern becomes narrower with an increase in the resonance frequency of the transducer.
Untangling Tau and Iron: Exploring the Interaction Between Iron and Tau in Neurodegeneration

There is an emerging link between the accumulation of iron in the brain and abnormal tau pathology in a number of neurodegenerative disorders, such as Alzheimer’s disease (AD). Studies have demonstrated that iron can regulate tau phosphorylation by inducing the activity of multiple kinases that promote tau hyperphosphorylation and potentially also by impacting protein phosphatase 2A activity. Iron is also reported to induce the aggregation of hyperphosphorylated tau, possibly through a direct interaction via a putative iron binding motif in the tau protein, facilitating the formation of neurofibrillary tangles (NFTs). Furthermore, in human studies high levels of iron have been reported to co-localize with tau in NFT-bearing neurons. These data, together with our own work showing that tau has a role in mediating cellular iron efflux, provide evidence supporting a critical tau:iron interaction that may impact both the symptomatic presentation and the progression of disease. Importantly, this may also have relevance for therapeutic directions, and indeed, the use of iron chelators such as deferiprone and deferoxamine have been reported to alleviate the phenotypes, reduce phosphorylated tau levels and stabilize iron regulation in various animal models. As these compounds are also moving towards clinical translation, then it is imperative that we understand the intersection between iron and tau in neurodegeneration. In this article, we provide an overview of the key pathological and biochemical interactions between tau and iron. We also review the role of iron and tau in disease pathology and the potential of metal-based therapies for tauopathies.
Simple Bounds for the Symmetric Capacity of the Rayleigh Fading Multiple Access Channel

Communication over the i.i. d. Rayleigh slow-fading MAC is considered, where all terminals are equipped with a single antenna. Further, a communication protocol is considered where all users transmit at (just below) the symmetric capacity (per user) of the channel, a rate which is fed back (dictated) to the users by the base station. Tight bounds are established on the distribution of the rate attained by the protocol. In particular, these bounds characterize the probability that the dominant face of the MAC capacity region contains a symmetric rate point, i.e., that the considered protocol strictly attains the sum capacity of the channel. The analysis provides a non-asymptotic counterpart to the diversity-multiplexing tradeoff of the multiple access channel. Finally, a practical scheme based on integer-forcing and space-time precoding is shown to be an effective coding architecture for this communication scenario.
Risk of childhood cerebral palsy following prenatal exposure to ß2-adrenergic receptor agonist: A nationwide cohort study

Background Cerebral palsy (CP) is the most common physical developmental disability in childhood with a prevalence of 2 to 3 per 1000 live births. β2-adrenoreceptor agonist (β2AA) are widely used for the treatment of asthma. Maternal use of β2AAs may increase the risk of adverse neuro-psychiatric health outcomes in the offspring. No study, however, has evaluated the effect of prenatal exposure to β2AAs on the risk of CP. Objective To examine the association between prenatal exposure to β2AAs and the risk of childhood cerebral palsy. Methods This population-based cohort study included all live singleton births in Denmark from January 1, 1997 to December 31, 2003. The information on outpatient prescriptions of β2AAs was extracted from Danish National Prescription Registry. Children born to mothers who used β2AAs from 30 days before pregnancy until delivery were categorized as the exposed. To differentiate the effect of β2AAs from the underlying indications, the exposure window was further extended to 2 years before pregnancy and the exposed groups were re-defined to represent different periods of exposure to maternal use of β2AAs (use only before pregnancy, use only during pregnancy, and use both before and during pregnancy). Cases of CP were identified from the Danish Cerebral Palsy Register. Logistic regression was used to estimate incidence odds ratio (OR) of CP. Results Among all the 442,278 singletons, 19,616 (4.44%) were exposed to β2AAs in utero (from 30 days before pregnancy until delivery). The risk of childhood CP was 0.21% in exposed and 0.19% in unexposed group, yielding an adjusted OR (aOR) 1.12 (95% confidence interval (CI): 0.82, 1.53). When extending the exposure time window to 2 years prior to pregnancy, no overall significant association was observed regardless of the exposure period. However, an increased risk of CP (aOR = 1.41, 95%CI: 0.92, 2.18) for maternal β2AAs use during pregnancy was observed in female offspring, especially in those born at term (aOR = 1.65, 95%CI: 1.02, 2.67). This increase was mainly attributed to an increased risk in those born to mothers who used β2AAs both before and during pregnancy (aOR = 1.81, 95%CI: 0.99, 3.33). Conclusions We observed an association between maternal β2AAs use during pregnancy and an increased risk of CP in female offspring, but we could not rule out confounding by the underlying indications for β2AAs.
Experimental Study of Influence of Message Length on Communication Accuracy Using Beverage Plant Simulator

This study concerned the influences of message length on communication errors caused by human. Based on a beverage plant scenario and developed simulator, experiments were conducted to better understand the relation between the number of instructions and the occurrence of communication errors. The results confirmed that the less the number of commands in a message, the less the communication errors but the longer the used time.
Effect of thrombelastography on timing of coronary artery bypass grafting

The guiding value of thrombelastography (TEG) on the selection of surgical timing for patients scheduled for coronary artery bypass grafting (CABG) was investigated. A total of 90 subjects with acute coronary syndrome (ACS) treated between February 2014 and December 2016 in Henan Provincial People's Hospital were recruited. The patients received dual antiplatelet therapy (DAPT) and were scheduled for CABG. Subjects were randomly allocated into two groups, TEG group (n=45) and non-TEG group (n=45). Patients in the TEG group withheld medications at 24 h prior to surgery and received TEG examination. Based on maximum amplitude of adenosine diphosphate (MAADP), subjects were further grouped into three sub-groups with MAADP <35 mm, 35–50 mm, and >50 mm, and accordingly received CABG within 1 day, 3–5 days and 5 days later, respectively. Subjects in the control group (non-TEG group) received CABG 5–7 days after medication withdrawal. Chest drainage volume within 24 h after surgery and red blood cell transfusion during perioperative period were compared. Other recorded parameters were incubation period, intensive care unit length of stay, hospital stay, incidence of 30-day adverse events and readmission rate. The average waiting time before CABG for patients of TEG group was shorter compared with the commonly recommended time. The red blood cell transfusions during perioperative period of subjects in TEG group and non-TEG group were significantly different (P=0.23). The median hospital stay of subjects in TEG group was shorter than that of non-TEG group (P=0.037). The bleeding amount of patients in TEG group was 220.16±80.56 ml, which was significantly lower than that of non-TEG group (435.29±90.16). The difference was statistically significant (P=0.032). The results suggested that TEG assay-based evaluation of platelet function for patients scheduled for CABG reasonably guides surgeons with appropriate surgical timing and reduces the amount of time patients wait to be treated.
Performance Improvement of Optical Satellite Communications by Interleaved IEEE 802.11 LDPC

Optical wireless communication using a laser is a strong candidate for the next generation satellite communications due to its large bandwidth. However, the channel environment of satellite communications is very tough, suffering from fading by atmospheric turbulence. Therefore, a powerful channel coding such as low-density parity check (LDPC) code is required for error correction. In this paper, the performance of a LDPC code is evaluated in this harsh channel environment. At the same time, in order to improve the system performance further, an interleaving method in combination with a LDPC code is used to overcome the burst error problem, which frequently occurs in optical satellite communication systems (OSC). Simulation results show that 970 consecutive burst error bits can be recovered by using a large size LDPC code and the proposed type of interleaving.