Miracle-dz/UniFAR-FTUs huggingface dataset:
The effects of early diabetes on inner retinal neurons

Abstract Diabetic retinopathy is now well understood as a neurovascular disease. Significant deficits early in diabetes are found in the inner retina that consists of bipolar cells that receive inputs from rod and cone photoreceptors, ganglion cells that receive inputs from bipolar cells, and amacrine cells that modulate these connections. These functional deficits can be measured in vivo in diabetic humans and animal models using the electroretinogram (ERG) and behavioral visual testing. Early effects of diabetes on both the human and animal model ERGs are changes to the oscillatory potentials that suggest dysfunctional communication between amacrine cells and bipolar cells as well as ERG measures that suggest ganglion cell dysfunction. These are coupled with changes in contrast sensitivity that suggest inner retinal changes. Mechanistic in vitro neuronal studies have suggested that these inner retinal changes are due to decreased inhibition in the retina, potentially due to decreased gamma aminobutyric acid (GABA) release, increased glutamate release, and increased excitation of retinal ganglion cells. Inner retinal deficits in dopamine levels have also been observed that can be reversed to limit inner retinal damage. Inner retinal targets present a promising new avenue for therapies for early-stage diabetic eye disease.
Modeling the dynamics of interface morphology and crystal phase change in self-catalyzed GaAs nanowires

The droplet contact angle and morphology of the growth interface (vertical, tapered or truncated facets) are known to affect the zincblende (ZB) or wurtzite (WZ) crystal phase of III–V nanowires (NWs) grown by the vapor-liquid-solid method. Here, we present a model which describes the dynamics of the morphological evolution in self-catalyzed III–V NWs in terms of the time-dependent (or length-dependent) contact angle or top nanowire radius under varying material fluxes. The model fits quite well the contact angle dynamics obtained by in situ growth monitoring of self-catalyzed GaAs NWs in a transmission electron microscope. These results can be used for modeling the interface dynamics and the related crystal phase switching and for obtaining ZB-WZ heterostructures in III–V.
Skeletal Muscle Growth, Enzyme Activities, and the Development of Thermogenesis: A Comparison between Altricial and Precocial Birds

We examined activities of enzymes indicative of aerobic capacity (citrate synthase [CS]) and glycolytic capacity (pyruvate kinase [PK]) in pectoral and leg muscles of chicks of the European starling, northern bobwhite, and Japanese quail. The starling exhibits altricial development; the nestlings are highly dependent on their parents for food and maintenance of a high body temperature. In contrast, the quail species exhibit precocial development; at hatching, the chicks can feed themselves and thermoregulate under mild cold stress. In all three species, the proportion of muscle in the body increased with age; in addition, the proportion of pectoral muscle increased relative to that of leg muscle. Pyruvate kinase activity increased in all muscles, but especially in the pectoral muscles of the quail (from approximately 50 to 800 μmol/min · g wet mass [IU/g] through day 21). In contrast, CS increased rapidly in the pectoral muscle of the starling (from 10 to 150 IU/g between hatching and 16 d) but not in quail. Citrate synthase activity initially was high in the leg muscle of quail (40-70 IU/g) but decreased with age; in starling leg muscle, CS activity increased through day 8 and then remained constant at about 45-50 IU/g. In the bobwhite, lactate dehydrogenase activity, which is associated with glycolytic metabolism, closely paralleled that of PK Muscle-mass-specific metabolic scope, estimated from peak oxygen consumption under cold stress, was higher in neonates of both quail species than in starling neonates, but within 2 wk it increased to a higher level in the starling (30-38 mL/h · g muscle). In general, total metabolic scope per individual varied in proportion to the total CS activity, not PK activity, of the pectoral and leg muscles, regardless of species and age. However, increases in the activities of both CS and PK activities in the starling during the first week were not accompanied by development of thermogenic capacity.
An InR/mir‐9a/NlUbx regulatory cascade regulates wing diphenism in brown planthoppers

Wing polymorphism significantly contributes to the ecological success of some insect species. For example, the brown planthopper (BPH) Nilaparvata lugens, which is one of the most destructive rice pests in Asia, can develop into either highly mobile long‐winged or highly fecund short‐winged adult morphs. A recent study reported a highly provocative result that the Hox gene Ultrabithorax (Ubx) is expressed in BPH forewings and showed that this wing development gene is differentially expressed in nymphs that develop into long‐winged versus short‐winged morphs. Here, we found that Ubx may be a mir‐9a target, and used dual luciferase reporter assays and injected micro RNA (miRNA) mimics and inhibitors to confirm the interactions between mir‐9a and NlUbx. We measured the mir‐9a and NlUbx expression profiles in nymphs and found that the expression of these two biomolecules was negatively correlated. By rearing BPH nymphs on host rice plants with different nutritional status, we were able to characterize a regulatory cascade between insulin receptor genes, mir‐9a, and NlUbx that regulate wing length in BPHs. When host quality was low, NlInR1 expression in the nymph terga increased and NlInR2 expression decreased; this led to a higher mir‐9a level, which in turn reduced the NlUbx transcript level and ultimately resulted in longer wing lengths. Beyond extending our understanding of the interplay between host plant status and genetic events that modulate polymorphism, we demonstrated both the upstream signal and miRNA‐based regulatory mechanism that control Ubx expression in BPH forewings.
Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences?

Gestational diabetes mellitus (GDM) is the most common pregnancy complication worldwide and may result in short-term and long-term consequences for offspring. The present review highlights evidence of epigenetic programming, mostly from human studies, which occurs in offspring exposed to maternal GDM during different stages of development, paying special attention to the differences in sensitivity of offspring to maternal hyperglycemia as a result of sex-related factors. We also aim to answer the following question: If these epigenetic changes are constant throughout the lifetime of the offspring, how do they present phenotypically?
Spread of ST348 Klebsiella pneumoniae Producing NDM-1 in a Peruvian Hospital

The aim of this study was to characterize carbapenem-resistant Klebsiella pneumoniae (CR-Kp) isolates recovered from adults and children with severe bacteremia in a Peruvian Hospital in June 2018. Antimicrobial susceptibility was determined by disc/gradient diffusion and broth microdilution when necessary. Antibiotic resistance mechanisms were evaluated by PCR and DNA sequencing. Clonal relatedness was assessed using pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Plasmid typing was performed with a PCR-based method. Thirty CR-Kp isolates were recovered in June 2018. All isolates were non-susceptible to all β-lactams, ciprofloxacin, gentamicin and trimethoprim-sulfamethoxazole, while mostly remaining susceptible to colistin, tigecycline, levofloxacin and amikacin. All isolates carried the blaNDM-1 gene and were extended spectrum β-lactamase (ESBL) producers. PFGE showed four different pulsotypes although all isolates but two belonged to the ST348 sequence type, previously reported in Portugal. blaNDM-1 was located in an IncFIB-M conjugative plasmid. To our knowledge, this is the first report of an New Delhi metallo-β-lactamase (NDM)-producing K. pneumoniae recovered from both children and adults in Lima, Peru, as well as the first time that the outbreak strain ST348 is reported in Peru and is associated with NDM. Studies providing epidemiological and molecular data on CR-Kp in Peru are essential to monitor their dissemination and prevent further spread.
Autonomic Dysfunction and Blood Pressure in Glaucoma Patients: The Lifelines Cohort Study

Purpose We investigated relationship of glaucoma with measurements related to autonomic dysfunction, including heart rate variability (HRV) and blood pressure (BP). Methods Glaucoma was defined using a questionnaire-based algorithm for 86,841 LifeLines Cohort Study participants. Baseline HRV (root mean square of successive differences [RMSSD]) was calculated from resting electrocardiograms; systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP) were oscillometric-based measurements. We used a generalized linear mixed model, adjusted for age, age square, sex, body mass index, and familial relationships to assess the relationship of baseline HRV and BP (continuous and quartiles), hypertension, and antihypertensive medication with glaucoma at follow up (median, 3.8 years). Results The odds ratio (OR) of glaucoma was 0.95 (95% confidence interval [CI], 0.92–0.99) per unit increase in log-transformed RMSSD (in ms), indicating that autonomous dysfunction (low HRV) is associated with a higher risk of glaucoma. Per 10-mm Hg increase in BP, we found ORs of 1.03 (95% CI, 1.01–1.05; P = 0.015) for SBP, 1.01 (95% CI, 0.97–1.05; P = 0.55) for DBP, 1.03 (95% CI, 1.00–1.06; P = 0.083) for MAP, and 1.04 (95% CI, 1.01–1.07; P = 0.006) for PP. The OR for the lowest versus highest RMSSD quartile was 1.15 (95% CI, 1.05–1.27; P = 0.003). The ORs for the highest versus second quartile were 1.09 (95% CI, 0.99–1.19; P = 0.091) for SBP and 1.13 (95% CI, 1.02–1.24; P = 0.015) for PP. Glaucoma was more common among hypertensives (OR, 1.25; 95% CI, 1.16–1.35; P < 0.001); among those using angiotensin-converting enzyme (ACE) inhibitors (OR, 1.35; 95% CI, 1.18–1.55; P < 0.001); and among those using calcium-channel blockers (OR, 1.19; 95% CI, 1.01–1.40; P = 0.039). Conclusions Low HRV, high SBP, high PP, and hypertension were associated with glaucoma. Longitudinal studies may elucidate if autonomic dysregulation and high BP also predict glaucoma incidence.
Unsupervised Visual–Textual Correlation Learning With Fine-Grained Semantic Alignment

With the rapid growth of multimedia data on the Internet, there has been a rapid rise in the demand for visual–textual cross-media retrieval between images and sentences. However, the heterogeneous property of visual and textual data brings huge challenges to measure the cross-media similarity for retrieval. Although existing methods have achieved great progress with the strong learning ability of the deep neural network, they rely heavily on the scale of training data with manual annotation, that is, either pairwise image–sentence annotation or category annotation as supervised information for visual–textual correlation learning, which are extremely labor and time consuming to collect. Without any pairwise or category annotation, it is highly challenging to construct a correlation between images and sentences due to their inconsistent distributions and representations. But people can naturally understand the correlation between visual and textual data in high-level semantic, and those images and sentences containing the same group of semantic concepts can be easily matched in human brain. Inspired by the above human cognitive process, this article proposes an unsupervised visual–textual correlation learning (UVCL) approach to construct correlations without any manual annotation. The contributions are summarized as follows: 1) unsupervised semantic-guided cross-media correlation mining is proposed to bridge the heterogeneous gap between visual and textual data. We measure the semantic matching degree between images and sentences, and generate descriptive sentences according to the concepts extracted from images to further augment the training data in an unsupervised manner. Therefore, the approach can exploit the semantic knowledge within both visual and textual data to reduce the gap between them for further correlation learning and 2) unsupervised visual–textual fine-grained semantic alignment is proposed to learn cross-media correlation by aligning the fine-grained visual local patches and textual keywords with fine-grained soft attention as well as semantic-guided hard attention, and the results can effectively highlight the fine-grained semantic information within both images and sentences to boost visual–textual alignment. Extensive experiments are conducted to perform visual–textual cross-media retrieval in unsupervised setting without any manual annotation on two widely used datasets, namely, Flickr-30K and MS-COCO, which verify the effectiveness of our proposed UVCL approach.
Composition of Intracellular and Cell Wall-Bound Phlorotannin Fractions in Fucoid Algae Indicates Specific Functions of These Metabolites Dependent on the Chemical Structure

Accumulation of biologically active metabolites is a specific feature of plant biochemistry, directing the use of plants in numerous applications in the pharmaceutical and food industries. Among these substances, the plethora of phenolic compounds has attracted particular interest among researchers. Here, we report on new findings in phlorotannin research, a large group of multifunctional phenolic substances, produced in brown algae. Comprehensive LC-MS profiling of three algal species allowed us to depict the complex pattern of this structurally diverse compound group across different tissues and subcellular compartments. We compiled more than 30 different phlorotannin series in one sample and used accurate mass spectrometry to assign tentative structures to the observed ions based on the confirmed sum formulas. From that, we found that acetylation, hydroxylation, and oxidation are likely to be the most common in vivo modifications to phlorotannins. Using an alternative data mining strategy to cope with extensive coelution and structural isomers, we quantitatively compared the intensity of different phlorotannin series in species, tissues, and subcellular compartments to learn more about their physiological functions. The structure and intra-thallus profiles of cell wall-bound phlorotannins were studied here for the first time. We suggest that one of the major dibenzodioxin-type phlorotannin series may exclusively target integration into the cell wall of fucoid algae.
Plagues of Desert Locusts: Very Low Invasion Risk to China

Simple Summary During the latest upsurge of the desert locust, swarms in northern Pakistan and India approached the Chinese border areas. In view of the recent windborne movement into China of another very serious migratory pest, the fall armyworm moth, we investigated the risk of the desert locust invading China. Our analysis shows that China is not likely to experience invasions of desert locust swarms (except, possibly, very marginal incursions on the Nepal border) and there was no likelihood that desert locust would become established in China over the next few decades. Abstract Recently, the most serious upsurge of the desert locust (Schistocerca gregaria) in the last 25 years is spreading across eastern Africa and southwestern Asia. Parts of the desert locust ‘invasion area’, namely the northern border areas of Pakistan and India, are very close to China, and whether locust swarms will invade China is of wide concern. To answer this question, we identified areas of potentially suitable habitat for the desert locust within China based on historical precipitation and temperature data, and found that parts of Xinjiang and Inner Mongolia provinces could provide ephemeral habitat in summer, but these places are remote from any other desert locust breeding areas. New generation adults of the desert locust in Pakistan and India present since April led to swarms spreading into the Indo-Pakistan border region in June, and so we examined historical wind data for this period. Our results showed that winds at the altitude of locust swarm flight blew eastward during April–June, but the wind speeds were quite slow and would not facilitate desert locust eastward migration over large distances. Simulated trajectories of desert locust swarms undertaking 10-day migrations mostly ended within India. The most easterly point of these trajectories just reached eastern India, and this is very close to the eastern border of the invasion area of desert locusts described in previous studies. Overall, the risk that the desert locust will invade China is very low.
Taraxerone triterpene inhibits cancer cell growth by inducing apoptosis in non-small cell lung cancer cells

The objective of the present study was to evaluate the anti-cancer effects of taraxerone in non-small cell lung cancer cells (A-549). The effect of this compound on apoptosis and cellular morphology was also studied. MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay was used to evaluate the effect of the compound on cell viability. Cellular morphology after taraxerone treatment was demonstrated by fluorescence microscopy and transmission electron microscopy. The results revealed that taraxerone induced dose-dependent as well as time-dependent growth inhibitory effects on A-549 cell line showing an IC 50 value of 53.2 and 61.6 µM at 24 hours and 48 hours time intervals respectively. It also inhibited cancer cell colony formation in a dose-dependent manner and around 90% of the cancer cells were destroyed by the 125 µM dose of taraxerone treatment. Taraxerone also induced cell shrinkage, chromatin condensation and nuclear membrane rupture which are characteristic of apoptosis.
Comparison of Postoperative Renal Function between Non-Steroidal Anti-Inflammatory Drug and Opioids for Patient-Controlled Analgesia after Laparoscopic Nephrectomy: A Retrospective Cohort Study

Non-steroidal anti-inflammatory drugs (NSAIDs) can be used as opioid alternatives for patient-controlled analgesia (PCA). However, their use after nephrectomy has raised concerns regarding possible nephrotoxicity. This study compared postoperative renal function and postoperative outcomes between patients using NSAID and patients using opioids for PCA in nephrectomy. In this retrospective observational study, records were reviewed for 913 patients who underwent laparoscopic or robot-assisted laparoscopic nephrectomy from 2015 to 2017. After propensity score matching, 247 patients per group were analyzed. Glomerular filtration rate (GFR) percentages (postoperative value divided by preoperative value), blood urea nitrogen (BUN)/creatinine ratios, and serum creatinine percentages were compared at 2 weeks, 6 months, and 1 year after surgery between users of NSAID and users of opioids for PCA. Additionally, postoperative complication rates, postoperative acute kidney injury (AKI) incidences, postoperative pain scores, and lengths of hospital stay were compared between groups. Postoperative GFR percentages, BUN/creatinine ratios, and serum creatinine percentages were similar between the two groups. There were no significant differences in the rates of postoperative complications, incidences of AKI, and pain scores at 30 min, 6 h, 48 h, or 7 days postoperatively. The length of hospital stay was significantly shorter in the NSAID group than in the opioid group. This study showed no association between the use of NSAID for PCA after laparoscopic nephrectomy and the incidence of postoperative renal dysfunction.
Psychometric Properties of the Interpersonal Styles Questionnaire for Physical Education in a Mexican Sample

During physical education classes, one of the contextual factors that can influence motivation is the teacher’s interpersonal style. The aim of this study was to analyze the psychometric properties, structure, and factorial invariance across gender of the physical education teachers’ Interpersonal Styles Questionnaire of Sonora, Mexico. The participants were 500 students (50.8% boys, 49.2% girls) aged between 9 and 13 years old (mean age (Mage) = 10.72; standard deviation (SD) = 0.74) from different elementary schools of Sonora, Mexico. In terms of measuring the teacher’s interpersonal styles, the short version of the Learning Climate Questionnaire was used to measure autonomy support, whereas the Teacher Controllingness Scale was used to measure controlling style. The results support the structure and factorial invariance across gender groups of the Mexican version of the Interpersonal Styles Questionnaire for Physical Education (Cuestionario de Estilos Interpersonales en la Educación Física (CEI-EF, by its initials in Spanish)). In conclusion, the CEI-EF is a valid and reliable instrument that can be used to assess the teachers’ interpersonal styles and draw comparisons between groups of boys and girls.
Brown Seaweeds for the Management of Metabolic Syndrome and Associated Diseases

Metabolic syndrome is characterized by the coexistence of different metabolic disorders which increase the risk of developing type 2 diabetes mellitus and cardiovascular diseases. Therefore, metabolic syndrome leads to a reduction in patients’ quality of life as well as to an increase in morbidity and mortality. In the last few decades, it has been demonstrated that seaweeds exert multiple beneficial effects by virtue of their micro- and macronutrient content, which could help in the management of cardiovascular and metabolic diseases. This review aims to provide an updated overview on the potential of brown seaweeds for the prevention and management of metabolic syndrome and its associated diseases, based on the most recent evidence obtained from in vitro and in vivo preclinical and clinical studies. Owing to their great potential for health benefits, brown seaweeds are successfully used in some nutraceuticals and functional foods for treating metabolic syndrome comorbidities. However, some issues still need to be tackled and deepened to improve the knowledge of their ADME/Tox profile in humans, in particular by finding validated indexes of their absorption and obtaining reliable information on their efficacy and long-term safety.
Listening and learning from traditional knowledge and western science: A dialogue on contemporary challenges of forest health and wildfire

Native Americans relied on fire to maintain a cultural landscape that sustained their lifeways for thousands of years. Within the past 100 years, however, policies of fire exclusion have disrupted ecological processes, elevating risk of wildfire, insects, and disease, affecting the health and availability of resources on which the tribes depend. On Indian Reservations, tribal forest plans include prescribed fire to restore and maintain the lands. Public land managers are now considering ways to restore the fire-based ecosystem, but tribal knowledge about the use and effects of fire has largely been left out of the discussion. For 2 days in June 2010, 7 tribal elders joined with 20 native and nonnative scientists, resource managers, and academics to explore ways to integrate Native American stewardship practices, traditional knowledge, and philosophies with western science to address contemporary forest health and wildfire challenges. The workshop, convened on the Flathead Indian Reservation of the Confederated Salish Kootenai Tribes located in western Montana, provided a forum for candid dialogue and knowledge sharing. This article, coauthored by all 27 participants, offers a summary background followed by candid highlights of dialogue along with recommendations for progress based on lessons learned. The central conclusion is that integration and application of traditional knowledge with western science for improved stewardship of natural resources will require enduring commitments to knowledge sharing that extend beyond the usual boundaries of professional training and cultural orientation such that learning can proceed, legacy myths might be corrected, and the forests and the people will benefit.