Miracle-dz/UniFAR-FTUs huggingface dataset:
Comprehensive analysis of lncRNA‐TF crosstalks and identification of prognostic regulatory feedback loops of glioblastoma using lncRNA/TF‐mediated ceRNA network

Glioblastoma (GBM) has become the most aggressive primary brain tumor in the world. Patients with GBM usually have a poor prognosis. The median survival times of GBM patients retain less than 2 years. Thus, it is urgent to investigate the molecular mechanism of GBM. Recently, studies have demonstrated that transcription factors (TFs) participate in cancer pathology by regulating long noncoding RNAs (lncRNAs). However, the functional and regulatory roles of TF‐lncRNA crosstalks are still unclear. In this study, we constructed a global lncRNA‐TF network (GLTN) based on competing endogenous RNA. As a result, some topological features of GLTN were identified. A known GBM lncRNA MCM3AP‐AS1 showed multiple central topological features in GLTN. Furthermore, we identified hub genes and extracted the hub‐hub pairs from GLTN to form a hub associated lncRNA‐TF network (HALTN). Results showed that a risk model combined with multiple hubs had a significant effect on prognosis. Additionally, we performed module searching and two functional modules from HALTN were identified, which were confirmed as risk factors of GBM. More importantly, we also identified some core lncRNA‐TF crosstalks that might form feedback loops to control the biological processes in GBM. Our results demonstrated that the synergistic, competitive lncRNA‐TF crosstalks played an important role in pathological processes of GBM, and had strong effect on prognosis. All these results can help us to uncover the molecular mechanism and provide a new therapeutic target for GBM.
Age and emotion regulation in daily life: Frequency, strategies, tactics, and effectiveness.

Models of aging and emotion hypothesize age differences in emotion regulation-in frequency, use of strategies, and/or effectiveness-but research to date has been mixed. In the current experience sampling study, younger, middle-aged, and older adults (N = 149), were prompted 5 times a day for 10 days to report on both general strategies (e.g., situation selection, cognitive change) and specific tactics. For each of the 5 strategies proposed by Gross's process model, tactics included those that introduced/increased positive aspects, avoided/decreased negative, and engaged with negative. Consistent with socioemotional selectivity theory, older adults reported less contra-hedonic motivation than younger, but this did not necessarily translate into age differences in regulation frequency or strategy use. Across the sample, strong preferences emerged for strategies intervening early in the emotional process and for tactics that introduced/increased positive aspects; a pattern that was even stronger in older adults. Middle-aged people more often avoided and reduced negative situations, whereas younger adults more often (though rarely) sought out or exacerbated negative situations. Effectiveness varied across strategies and tactics, but age differences only emerged for situation selection and reducing negative aspects of the situation (both less effective for older than younger adults). This research highlights the importance of studying how emotion regulation strategies are implemented in real life situations and suggests that age differences in emotion regulation, when they do emerge, may be more a matter of degree than of type. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Surgical treatment of peri-implantitis - Consensus report of working group 4.

The following consensus report is based on four background reviews (Keeve et al., Implant Dent 2019 28(2): 177-186; Ramanauskaite et al., Implant Dent 2019 28(2): 187-209; Koo et al., Implant Dent 2019 28(2): 173-176; Sculean et al., Implant Dent 2019 210-216). The surgical treatment of peri-implantitis is indicated in the cases where the first choice of treatment, the non-surgical one, failed with recurrence of bleeding and suppuration. The aim of this review was to systematically screen the literature for possible surface decontamination techniques and material during surgical treatment, the surgical regenerative and non-regenerative treatments of peri-implantitis, radiological and clinical outcomes, the importance of the presence of fixed and or keratinised peri-implant gingiva, and to determine predictable therapeutic options for the clinical surgical management of peri-implantitis lesions. Existent clinical, radiographic and microbiological data do not favour any decontamination approaches and fail to show the influence of a particular decontamination protocol on surgical therapy. Using implantoplasty in surgical non-regenerative treatment leads to a significant decrease in bleeding on probing and probing depth, and may result in improvement of clinical and radiographic parameters, up to 3 years after surgery compared with mechanical debridement alone. Surgical augmentative peri-implantitis therapy resulted in improved clinical and radiographic treatment outcomes compared with the baseline in the majority of studies with 6 months to 7-10 years of follow-up. There is no evidence to support the superiority of a specific material, product or membrane in terms of long-term clinical benefits. The best treatment modality to improve the width of keratinised attached mucosa and bleeding and plaque scores, and to sustain the peri-implant marginal bone level, is the use of an apically positioned flap combined with a free gingival graft.
Clonal evolution of acute myeloid leukemia from diagnosis to relapse

Based on the individual genetic profile, acute myeloid leukemia (AML) patients are classified into clinically meaningful molecular subtypes. However, the mutational profile within these groups is highly heterogeneous and multiple AML subclones may exist in a single patient in parallel. Distinct alterations of single cells may be key factors in providing the fitness to survive in this highly competitive environment. Although the majority of AML patients initially respond to induction chemotherapy and achieve a complete remission, most patients will eventually relapse. These points toward an evolutionary process transforming treatment‐sensitive cells into treatment‐resistant cells. As described by Charles Darwin, evolution by natural selection is the selection of individuals that are optimally adapted to their environment, based on the random acquisition of heritable changes. By changing their mutational profile, AML cell populations are able to adapt to the new environment defined by chemotherapy treatment, ultimately leading to cell survival and regrowth. In this review, we will summarize the current knowledge about clonal evolution in AML, describe different models of clonal evolution, and provide the methodological background that allows the detection of clonal evolution in individual AML patients. During the last years, numerous studies have focused on delineating the molecular patterns that are associated with AML relapse, each focusing on a particular genetic subgroup of AML. Finally, we will review the results of these studies in the light of Darwinian evolution and discuss open questions regarding the molecular background of relapse development.
Temporal Trends and Patterns in Mortality After Incident Heart Failure

Key Points Question Why has there been no improvement in the prognosis for patients with heart failure over the past 15 years when considerable advances in heart failure care have been introduced during the same period? Findings In this cohort study of patients who received a new diagnosis of heart failure between 2002 and 2013 in the United Kingdom, cardiovascular mortality declined by 27% and premature deaths from any cause declined by 21%. Improvements to overall mortality were hindered by noncardiovascular diseases, which represented most deaths and increased by 22% over time. Meaning Management strategies that solely target cardiovascular outcomes appear insufficient to improve the survival of patients with heart failure; the management of associated comorbidities, particularly infection prevention, appears as a major priority and opportunity.
Intraoperative Methadone Reduces Pain and Opioid Consumption in Acute Postoperative Pain: A Systematic Review and Meta-analysis.

BACKGROUND Methadone is a potent opioid exerting an analgesic effect through N-methyl-D-aspartate receptor antagonism and the inhibition of serotonin and noradrenaline reuptake. It has also been used in several procedures to reduce postoperative pain and opioid use. This meta-analysis aimed to determine whether the intraoperative use of methadone lowers postoperative pain scores and opioid consumption in comparison to other opioids. METHODS Double-blinded, controlled trials without language restrictions were included from MEDLINE, Embase, LILACS, The Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL via EBSCOhost. The included studies tracked total opioid consumption, postoperative pain scores, opioid-related side effects, and patient satisfaction until 72 hours postoperatively. Mean difference (MD) was used for effect size. RESULTS In total, 476 articles were identified and 13 were considered eligible for inclusion in the meta-analysis. In 486 patients (7 trials), pain at rest (MD, 1.09; 95% confidence interval (CI), 1.47-0.72; P < . 00001) and at movement (MD, 2.48; 95% CI, 3.04-1.92; P = .00001) favored methadone 24 hours after surgery. In 374 patients (6 trials), pain at rest (MD, 1.47; 95% CI, 3.04-1.02; P < .00001) and at movement (MD, 2.03; 95% CI, 3.04-1.02; P < .00001) favored methadone 48 hours after surgery. In 320 patients (4 trials), pain at rest (MD, 1.02; 95% CI, 1.65-0.39; P = .001) and at movement (MD, 1.34; 95% CI, 1.82-0.87; P < .00001) favored methadone 72 hours after surgery. A Trial Sequential Analysis was performed and the Z-cumulative curve for methadone crossed the monitoring boundary at all evaluations, additionally crossing Required Information Size at 24 and 48 hours at rest. Methadone group also showed lower postoperative opioid consumption in morphine equivalent dosage (mg) at 24 hours (MD, 8.42; 95% CI, 12.99-3.84 lower; P < .00001), 24-48 hours (MD, 14.33; 95% CI, 26.96-1.91 lower; P < .00001), 48-72 hours (MD, 3.59; 95% CI, 6.18-1.0 lower; P = .007) postoperatively. CONCLUSIONS Intraoperative use of methadone reduced postoperative pain scores compared to other opioids, and Trial Sequential Analysis suggested that no more trials are required to confirm pain reduction at rest until 48 hours after surgery. Methadone also reduced postoperative opioid consumption and led to better patient satisfaction scores through 72 hours postoperatively compared to other opioids.
Characterizing the Financial Value of In-Home Palliative Care for Patients, Payers, and Hospitals

Background: The holistic and multidisciplinary approach of in-home palliative care (IHPC) is known to offer high-quality and cost-effective care for patients at the end of life. However, the financial benefits of upstream IHPC programs to hospitals, patients, and payers have not been fully characterized for patients with comorbid chronic conditions. Aim: To characterize the financial benefits that upstream IHPC offers to patients with multiple chronic conditions. Methods: A structured retrospective patient record review was conducted on the number of emergency department (ED) visits, number of inpatient hospitalizations, hospital length of stay (LOS), and payments made to the hospital for all patients (N = 71) enrolled in an IHPC program between January 1, 2016, and June 30, 2016. Discharge history from each patient’s medical record was also assessed. Comparisons were drawn between patients’ LOS on IHPC and an equivalent time period prior to enrollment in IHPC. Results: After patients enrolled in IHPC, average ED and inpatient utilization declined significantly by 41% (P = .01) and 71% (P < .001), respectively. The payers for health-care services realized a significant decline of US$2,201 (P < .001) in hospital payments per patient per month. Inpatient LOS was also significantly lower than expected once patients enrolled in the program (P = .01). Conclusions: As the need for chronic disease management continues to grow, managers of health systems, managed care organizations, and home health agencies should be cognizant of the financial value that IHPC has to offer.
Impact of age and comorbidities on the effect of transcatheter versus surgical mitral valve repair on inpatient outcomes

Transcatheter mitral valve repair (TMVR) has shown to be a safe and effective treatment option for symptomatic severe mitral regurgitation (MR) in patients who are at prohibitive surgical risk. Whether age and comorbidities impact the inpatient safety outcomes of TMVR versus surgical mitral valve repair (SMVR) is unknown.
Body Composition as Mediator between the Physical Fitness on Bone Mass during Growth.

INTRODUCTION AND PURPOSE To examine the effect of cardiorespiratory fitness (CRF) and muscle power output (MPO) on bone mass of prepubertal and pubertal children using lean mass (LM) and percentage of fat mass (%FM) as mediator variables. The hypothesis was that both LM and %FM would be independent mediators of the relationships during the sexual maturation period. METHODS We analyzed 200 children [88 boys and 112 girls (11.5±2.0 years)]. Body composition was analysed by bone densitometry and, indirect calorimetry and cycle-ergometer were used to calculate VO2peak (ml·kg·min) and MPO (W) during an incremental exercise test. Sample was divided by pubertal status. RESULTS In the prepubertal group, LM and %FM acted independently as mediators in the relationship between bone mass and CRF or MPO (22%-25% for LM and 37%-50% for %FM respectively). In pubertal children, LM acted as mediator at 37%. CONCLUSION Although the independent mediator role of LM and %FM in the associations between CRF or MPO and bone mass was present during the prepubertal stage, only LM remain its mediator role in these associations during the postpubertal period. Therefore, with growth and sexual maturation, the full effect of LM seems to increase, while the influence of %FM seems to disappear.
An update on the biology and management of dyskeratosis congenita and related telomere biology disorders

ABSTRACT Introduction: Telomere biology disorders (TBDs) encompass a group of illnesses caused by germline mutations in genes regulating telomere maintenance, resulting in very short telomeres. Possible TBD manifestations range from complex multisystem disorders with onset in childhood such as dyskeratosis congenita (DC), Hoyeraal-Hreidarsson syndrome, Revesz syndrome and Coats plus to adults presenting with one or two DC-related features. Areas covered: The discovery of multiple genetic causes and inheritance patterns has led to the recognition of a spectrum of clinical features affecting multiple organ systems. Patients with DC and associated TBDs are at high risk of bone marrow failure, cancer, liver and pulmonary disease. Recently, vascular diseases, including pulmonary arteriovenous malformations and gastrointestinal telangiectasias, have been recognized as additional manifestations. Diagnostics include detection of very short leukocyte telomeres and germline genetic testing. Hematopoietic cell transplantation and lung transplantation are the only current therapeutic modalities but are complicated by numerous comorbidities. This review summarizes the pathophysiology underlying TBDs, associated clinical features, management recommendations and therapeutic options. Expert opinion: Understanding TBDs as complex, multisystem disorders with a heterogenous genetic background and diverse phenotypes, highlights the importance of clinical surveillance and the urgent need to develop new therapeutic strategies to improve health outcomes.
A Molecular Dynamics Study of Aqueous Solutions

Abstract Results of a molecular dynamics study of aqueous solutions of LiJ, LiCl, NaCl, CsCl and CsF are reported. The basic periodic box contained 200 water molecules, 8 cations and 8 anions, equivalent to 2.2 molal solutions. Static properties of the first hydration shells of the ions are discussed in detail on the basis of radial pair correlation functions, average potential energies of the water molecules and pair interaction energy distributions. The calculations lead to the conclusion that in the first hydration shells a lone pair orbital of the water molecule is directed towards the cation while a hydrogen atom points towards the anion. In the five alkali halide solutions investigated ion pairing occurs only with CsF. The hydration numbers, when defined as the volume integrals of the ion-water radial pair correlation functions up to the first minimum, increase with increasing ion size and depend on the size of the counterion. The water-water interactions in the solutions show not only features of pure water at elevated temperatures but also of pure water under compresion. The agreement between calculated and measured self diffusion coefficients is still insufficient.
A Neoclassical Theory of Wealth Distribution

In his pioneering article on economic growth, Solow remarked: 'All theory depends on assumptions which are not quite true. That is what makes it theory. The art of successful theorizing is to make the inevitable simplifying assumptions in such a way that the final results are not very sensitive. A "crucial" assumption is one on which the conclusions do depend sensitively, and it is important that crucial assumptions be reasonably realistic'. [1, p. 58. ] The first aim of this paper is to show that in the model of wealth distribution as proposed by Stiglitz [2], the assumption of a 1 i n e a r savings function is a crucial one in the above sense. If one replaces this assumption by the assumption of a convex savings function, i.e. an increasing marginal propensity to save, one arrives at qualitatively different conclusions. Since the analysis is considerably simplified by choosing the more sophisticated approach of Duesenberry's Relative Income Hypothesis (which allows furthermore for a simple introduction of Harrod-neutral technical progress into the model), this will be done in the present paper.
THE WORD

On decrit en general et depuis tres longtemps le mot coirime une unite de la description grammaticale. II est pourtant tres difficile d'etablir des criteres formels qui permettent de definir le mot comme une categorie generale. L'article est une contribution a la solution de ce probleme. Le mot est considere comme la plus petite unite divisible. Les criteres de cette divisibilite du mot sont dans ce cas: (a) son apparition a la frontiere des propositions, (b) la possibilite de changer sä place a l'interieur de la proposition et (c) l'insertion d'autres unites entre deux mots.
Traffic Signs

Road signs are the elements of roads with a lot of influence in driver’s behavior. So that signals can fulfill its function, they must overcome visibility and durability requirements, particularly needed at night, when the coefficient of retroreflection becomes a decisive factor in ensuring road safety. Accepting that the visibility of the signage has implications for people’s safety, we understand the importance to fulfill its function: to foster the highest standards of service and safety in drivers. The usual conditions of perception of any sign are determined by: age of the driver, reflective material, luminosity, vehicle speed and emplacement. In this way, this paper evaluates the different signals to increase the safety road. Keywords—Luminosity, orientation, retroreflection, traffic signs.
Prioritizing automated user interface tests using reinforcement learning

User interface testing validates the correctness of an application through visual cues and interactive events emitted in real world usages. Performing user interface tests is a time-consuming process, and thus, many studies have focused on prioritizing test cases to help maintain the effectiveness of testing while reducing the need for a full execution. This paper describes a novel prioritization method that combines Reinforcement Learning and interaction coverage testing concepts. While Reinforcement Learning has been found to be suitable for rapid changing projects with abundant historical data, interaction coverage considers in depth the event-based aspects of user interface testing and provides a granular level at which the Reinforcement Learning system can gain more insights into individual test cases. We experiment and assess the proposed method using five data sets, finding that the method outperforms related methods and has the potential to be used in practice.
The trails of Just Cause 2: spatio-temporal player profiling in open-world games

Behavioral profiling of players in digital games is a key challenge in game analytics, representing a particular challenge in Open-World Games. These games are characterized by large virtual worlds and few restrictions on player affordances. In these games, incorporating the spatial and temporal dimensions of player behavior is necessary when profiling behavior, as these dimensions are important to the playing experience. We present analyses that apply cluster analysis and the DEDICOM decompositional model to profile the behavior of more than 5,000 players of the major commercial title Just Cause 2 integrating both spatio-temporal trails and behavioral metrics. The application of DEDICOM to profile the spatio-temporal behavior of players is demonstrated for the purpose of analysing the entire play history of Just Cause 2 players, but also for the more detailed analysis of a single mission. This showcases the applicability of spatio-temporal profiling to condense player behavior across large sample sizes, across different scales of investigation. The method presented here provides a means to build profiles of player activity in game environments with high degrees of freedom across different scales of analysis - from a small segment to the entire game.
A Survey on PCM Lifetime Enhancement Schemes

Phase Change Memory (PCM) is an emerging memory technology that has the capability to address the growing demand for memory capacity and bridge the gap between the main memory and the secondary storage. As a resistive memory, PCM is able to store data based on its resistance values. The wide resistance range of PCM makes it possible to store even multiple bits per cell (MLC) rather than a single bit per cell (SLC). Unfortunately, PCM cells suffer from short lifetime. That means PCM cells could tolerate a limited number of write operations, and afterward they tend to permanently stick at a constant value. Limited lifetime is an issue related to PCM memory; hence, in recent years, many studies have been conducted to prolong PCM lifetime. These schemes have vast variety and are applied at different architectural levels. In this survey, we review the important works of such schemes to give insights to those starting to research on non-volatile memories (NVMs). These schemes are not limited to PCM and are applicable on other NVM technologies due to the similarities between them and the generality of lifetime-prolonging schemes.