Miracle-dz/UniFAR-FTUs huggingface dataset:
Cyanobacterial abundance and diversity in coastal wetlands of Kanyakumari District, Tamil Nadu (India)

Coastal wetlands are physiologically unique from freshwater and marine water environments. They support the growth of both marine and freshwater organisms with affluent diversity. In this study, abundance and diversity of cyanobacteria from the coastal wetlands of Kanyakumari District (Tamil Nadu) in India was studied. Water samples were collected from ten different sampling sites during the month of January 2010 to March 2010. Totally 17 morphologically different cyanobacteria were identified by microscopic examinations and culture-dependent processes. Both unicellular and filamentous cyanobacteria like Microcystis flos-aquae, Microcystis lamelliformis, Gloeocapsa sp, Aphanocapsa sp, Aphanothece sp and Synechocystis sp. Oscillatoria earlei, Oscillatoria pseudogeminata, Oscillatoria tenuis, Oscillatoria amoena, Phormidium fragile, Phormidium retzii, Phormidium sp. , Lyngbya sp, Symploca sp. Microchaete sp. and Spirulina subtilissima were identified. In addition, the species richness index was ranging from 0.779 to 1.097 in the samples collected in month of February (S8- Muttam). Substantial diversity was also detected in different sampling regions, Shannon-Wiener’s (H! ) diversity index of cyanobacterial population ranged from 0.423 to 0.788. In our findings, all the identified cyanobacteria were belonging to non heterocystous forms. Key words: Cyanobacteria, coastal wetland, Oscillatoriaceae, Chroococcaceae.
The Effects of a Cognitive Dual Task on Jump-landing Movement Quality

Abstract Investigations on movement quality deficits associated with jump landing are numerous, however, these studies are often performed in laboratories with little distraction to the participant. This is contrary to how injury typically occurs secondary to sport-specific distraction where the athlete is cognitively loaded during motor performance. Thus, the purpose of this study was to determine the effect of a cognitive load on jump-landing movement quality. A dual-task design was used to determine the effects of a dual-task on tuck jump movement quality in 20 participants. There were three cognitive conditions (no cognitive task, easy-cognitive task, and difficult-cognitive task). The dual task elicited statistically significant changes in overall tuck jump score (movement quality) across the conditions with tuck jump score increasing from 3.52±1.64 baseline to 4.37±1.25 with the easy-cognitive task to 4.67±1.24 with the difficult-cognitive task. The findings of this study may be useful to screen for individuals at risk of lower extremity injury utilizing the tuck jump when paired with a cognitive task. The screening would then identify individuals who may have poor neuromuscular control when cognitively loaded.
Safety and biological activity evaluation of Uncaria rhynchophylla ethanolic extract

Abstract Uncaria rhynchophylla (UR) belongs to the Rubiaceae family, and its dried hooks are usually used in traditional medicine. It is effective in treating diseases related to the central nervous system. This study aimed to evaluate the safety of UR extract, investigate its antimutagenic and antioxidative activities, and elucidate its active components. Extraction and fractionation of the UR extract resulted in yields of 6.71%, 0.037%, 0.042%, 0.152%, 0.332%, and 5.132%, for hexane, ether, DCM, EtOAC, and aqueous fractions, respectively. The four indole alkaloids, total phenolic content (TPC), and total flavonoid content (TFC) of UR extract and its subfractions were measured. Alkaloid content was highest in the UR extract. TPC was the highest in the EtOAC fraction (373.7 ± 20.9 mg gallic acid equivalent (GAE)/g), whereas TFC was the highest in the UR extract (33.5 ± 2.4 mg quercetin equivalent (QE)/g). To assess the safety of UR extract mutagenicity, cytotoxicity, and oxidative stress inducibility assays were performed. The UR extract (2000 µg/plate) showed excellent antimutagenic activity (above 90%) against BaP in both TA98 and TA100 strains. The UR extract exhibited efficient DPPH (RC50 239.2 ± 16.5 µg/mL) and ABTS scavenging activity (RC50 458.7 ± 25.0 µg/mL). The UR extract (150 µg/mL) showed cytoprotective activity (65.6% ± 9.2%) against t-BHP. Among the subfractions, the EtOAC fraction possessed the strongest activities, overall. UR generally showed excellent biological activity at nontoxic concentrations (determined in vitro in current work), although the chemical composition of UR requires further investigation prior to its potential future use.
Safer conception for female sex workers living with HIV in Dar es Salaam, Tanzania: Cross-sectional analysis of needs and opportunities in integrated family planning/HIV services

Background With the advent of effective treatment, women living with HIV can plan for pregnancy while minimizing risk of transmission to infants and seronegative partners. Family planning (FP) services tend to focus solely on addressing contraceptive need, but HIV-positive women—including female sex workers—often plan to have children someday. Various “safer conception” strategies are now available to support women living with HIV achieve fertility intentions, and integrated HIV/FP services may be a promising platform to offer these services. Methods At integrated community-based HIV/FP service delivery sites operated by Jhpiego’s Sauti project in Dar es Salaam, we conducted exit interviews with 300 HIV-positive female sex workers. Descriptive analyses were conducted to describe their desire for children, use of condoms and other modern contraceptive methods, self-reported viral suppression, and knowledge of and interest in safer conception strategies. We conducted bivariate and multivariate logistic regression analysis to examine correlates of fertility desire among respondents. Results Median age of participants was 32. Nearly one-third wished to have a child within two years. Seventy-two percent had heard of having the HIV-positive partner taking ART to reduce sexual transmission during pregnancy attempts. Thirty-one percent felt the amount of FP content covered in the consultation was “too little. ” Factors significantly associated with desire for children were having a nonpaying partner (adjusted odds ratio [AOR] 2.18, 95% confidence interval [CI]1.13–4.20) and having fewer children (AOR 0.65, 95% CI 0.48–0.87). Viral suppression was not associated with fertility desire. Conclusions Sex workers living with HIV attending integrated HIV/FP services have need for both contraception as well as safer conception counseling. This integrated service delivery modality is a promising platform for providing safer conception services. FP counseling for HIV-positive women should be broadened to broach the topic of safer pregnancy, as well as explicit counseling on strategies to minimize risk of sexual transmission to partners.
Multicenter Phase I/II Trial of Napabucasin and Pembrolizumab in Patients with Metastatic Colorectal Cancer (EPOC1503/SCOOP Trial)

Purpose: This is a phase I/II trial to assess the efficacy and safety of napabucasin plus pembrolizumab for metastatic colorectal cancer (mCRC). Patients and Methods: Phase I was conducted to determine the recommended phase 2 dose (RP2D) in a dose escalation design of napabucasin (240 to 480 mg twice daily) with 200 mg pembrolizumab every 3 weeks. Phase II included cohort A (n = 10, microsatellite instability high, MSI-H) and cohort B (n = 40, microsatellite stable, MSS). The primary endpoint was immune-related objective response rate (irORR). PD-L1 combined positive score (CPS), genomic profiles, and the consensus molecular subtypes (CMS) of colorectal cancer were assessed. Results: A total of 55 patients were enrolled in this study. In phase I, no patients experienced dose-limiting toxicities, and napabucasin 480 mg was determined as RP2D. The irORR was 50.0% in cohort A and 10.0% in cohort B. In cohort B, the irORR was 0%, 5.3%, and 42.9% in CPS < 1, 1≤ CPS <10, and CPS ≥ 10, respectively. Patients with objective response tended to have higher tumor mutation burden than those without. Of evaluable 18 patients for CMS classification in cohort B, the irORR was 33.3%, 0%, 33.3%, and 33.3% in CMS1, CMS2, CMS3, and CMS4, respectively. The common grade 3 or higher treatment-related adverse events included fever (10.0%) in cohort A and decreased appetite (7.5%) and diarrhea (5.0%) in cohort B. Conclusions: Napabucasin with pembrolizumab showed antitumor activity with acceptable toxicities for patients with MSS mCRC as well as MSI-H mCRC, although it did not meet the primary end point. The impact of related biomarkers on the efficacy warrants further investigations in the additional cohort. See related commentary by Nusrat, p. 5775
Phase 2 study of pembrolizumab for measurable residual disease in adults with acute lymphoblastic leukemia.

The presence of measurable residual disease (MRD) in acute lymphoblastic leukemia (ALL) confers a poor prognosis. CD19-targeted immunotherapy is effective against MRD but is logistically challenging, potentially toxic, and not applicable to T-cell ALL. We thus hypothesized that inhibition of PD-1 with pembrolizumab could also be effective for MRD, but without lineage restriction. The primary objective of this phase 2 study was to evaluate the efficacy of pembrolizumab in patients with ALL and MRD. Key eligibility criteria included adults with B- or T-cell ALL and MRD detectable by multiparameter flow cytometry or quantitative polymerase chain reaction from bone marrow aspirate (BMA) despite chemotherapy (plus ABL kinase inhibitor if Philadelphia chromosome positive). Pembrolizumab 200 mg IV was given every 3 weeks. Response was assessed by BMA using methods that previously detected MRD. The primary end point was complete MRD response rate. We stopped enrollment early; only 1 of 12 (8%) experienced a complete MRD response, which lasted 3 weeks. Interestingly, this patient had previously received hematopoietic cell transplantation and CD19-targeted chimeric antigen receptor-modified T-cell therapy and was the only patient to experience an immune-related adverse event from pembrolizumab (grade 3 Stevens-Johnson syndrome). Median overall survival from enrollment was 12.7 months. In summary, pembrolizumab had minimal activity against MRD but was generally well tolerated. These data can be compared with ongoing anti-PD-1 combination studies in ALL, and they further establish the role of trials specifically for patients with MRD. This trial was registered at www.clinicaltrials. gov as #NCT02767934.
Evaluation of pharyngeal airway dimensions and hyoid bone position according to craniofacial growth pattern

ABSTRACT Objective To compare pharyngeal airway dimensions and hyoid bone position in different craniofacial growth patterns. Methods In total, 611 patients divided into 9 subgroups were compared according to malocclusion classification and vertical growth pattern, and these subgroups were compared in terms of pharyngeal airway and hyoid measurements. A two-way ANOVA test was used to compare the findings of the subgroups. Results No significant difference was found for the pharyngeal measurements between the groups (p>0.05). The vertical airway length (PNS-Ep) was significantly shorter in the Class III malocclusion group (p<0.05) and in the hypodivergent group (p<0.05). No statistically significant difference was found between any subgroups in any measurements of the position of the hyoid bone (p>0.05). Conclusion The pharyngeal airway dimensions and hyoid bone position are similar among individuals in the sagittal direction. The vertical airway length is significantly shorter in Class III and hypodivergent individuals.
Patient Characteristics and Outcomes of Relapsed/Refractory Multiple Myeloma in Patients Treated with Proteasome Inhibitors in Germany

Introduction: Real-world data reflects treatments and outcomes in clinical practice in contrast with controlled clinical trials. This study evaluates real-life multiple myeloma (MM) patients receiving proteasome inhibitor (PI)-based treatments in the second or third therapy line in 2017 in Germany. Methods: This is a retrospective chart review on adult relapsed/refractory MM patients treated with ≥1 dose of a PI-based regimen in either the second or the third line of therapy. Participating physicians had ≥3 years of clinical experience in treating symptomatic MM patients and used PI according to the label. Results: Distinct patient profiles for each PI-based regimen emerged. Younger, fitter, transplant-eligible patients received novel PI triplets such as carfilzomib in combination with lenalidomide and dexamethasone (KRd) or IRd. Patients receiving lenalidomide in first-line therapy mostly received lenalidomide-free regimens in second-line therapy. In high-risk patients, no clear treatment patterns could be ascertained. The complete response rates were highest with KRd (13.0%), followed by carfilzomib in combination with dexamethasone (Kd) (5.7%) and bortezomib (4.8%). The very good partial response rates were highest with IRd (76.9%), followed by KRd (53.7%), Kd (25.7%), and bortezomib (20.5%). None of the KRd- or IRd-treated patients responded below a partial response. Discussion/Conclusion: Clear patient profiles for each PI type were observed. In second-line therapy, younger, fitter, transplant-eligible patients received novel-PI-based triplets, e.g., KRd or IRd. Patients treated with lenalidomide in first-line therapy mostly received lenalidomide-sparing regimens in second-line therapy. In high-risk patients no clear treatment patterns could be ascertained due to the limited sample size.
Development of a flash-based mobile learning system for English as second language

The objectives of this study were (1) to identify components needed for effective mLearning system, (2) to develop a Flash-based Mobile Learning system for English as a second language (FML4ESL), (3) to try out the FML4ESL in a simulated situation, and (4) to evaluate the effectiveness of the developed FML4ESL. In developing the FML4ESL plan, based on Adobe Flash-based multimedia mobile learning system where multimedia (text and sound) features of the mobile devices are utilized for learning English language as second language, A) a need assessment survey was conducted to evaluate the need for mobile learning in general and mobile English learning in particular; B) consultation with experts in mobile technology and ESL lecturers, a prototype system (FML4ESL) was designed, developed, and tested; C) volunteers among Assumption University students were used as sample to try out the developed system in order to explore and to evaluate its usefulness and effectiveness; D) ANOVA was utilized to compare the scores of pretests and posttests of participants in this research for evaluating its effectiveness and usefulness; and finally F) pre-surveys and post-surveys were utilized to evaluate the learners' satisfactions and effectiveness ofFML4ESL. In designing and developing the FML4ESL plan, the researcher followed seven steps: (1) review of documents, (2) survey of need for the system, (3) design conceptual framework for mLearning model, (4) survey of expert opinion, (5) a prototype for FML4ESL, (6) system verification, (7) finalize the FML4ESL. The prototype system was developed and tested. The results of pretest and posttests showed a statistically significant (p < 0.05) improvement in the scores of English proficiency tests after trying out the FML4ESL. The results of the surveys showed that Flash-based mobile learning for English as second language was effective in improving students' English proficiency especially in the area of pronunciation, listening, and reading comprehension. Participants in this research expressed the convenience and just-in-time learning of mobile learning as the positive and important aspects of learning English using their mobile devices. Participants expressed their desire to have access to more mobile English lessons and integration of FML4ESL to their existing English classes as supplements.
Letter to the Editor: Perioperative Complications of Spine Surgery in Elderly Patients in Japan vis-à-vis other Asian Nations.

indication of additional decompression or correction of kyphotic deformity. How did you determine severe kyphosis (C2–7 kyphosis >15-) as one of the exclusion criteria? According to the results, 53 cases (46.5%) of the 114 cases with preoperative kyphosis were found with postoperative kyphosis. Therefore, these exclusion criteria may be inappropriate for the decision-making. Perhaps more rigorous preoperative C2–7 kyphosis should be considered to minimize the risk of postoperative kyphosis. Besides, we find that there are inconsistent data presented in the results and figures. In the second paragraph of the results section and Figure 2, 101 patients were observed with postoperative kyphosis, including 48 patients in the lordosis group and 53 patients in the kyphosis group. However, in the fourth paragraph of the results section and Figure 4, only 100 patients were observed with postoperative kyphosis, including 20 patients with preoperative lordosis >6.5-, and 80 patients with preoperative lordosis <6.5-. Is there something wrong with the data?
Ant‐mimicry in some Brazilian salticid and clubionid spiders (Araneae: Salticidae, Glubionidae)*

This paper describes the morphological and behavioural adaptations responsible for ant-like appearance in eight species (genera zunigu, Synemosyna, Sphecotypus, and Myrmecium) of salticid and clubionid spiders studied in Amazonian and SE Brazil. All ant-mimicking spiders have body and legs thin, and the shiny integument typical of their models. Light horizontal hair bands and constrictions of the cephalothorax and abdomen simulate, respectively, the head-thorax joint and segmented gaster of ants. The petiole and postpetiole of the ants are usually mimicked by a lengthened pedicel, together with a narrowing of the posterior cephalothorax and/or anterior abdomen. The prominent pedipalps of the spiders often simulate ant mandibles, but they may also be strikingly similar to an ant’s head. All ant-mimicking spiders walked in a zig-zag ant-like pattern, and frequently raised and moved about the first pair of legs as ‘antennae’. The mimics were found in the same microhabitats (foliage or ground) as their models, and displayed strong avoidance reactions toward the latter both in the field and in captivity. The inoffensive characteristics of the mimics and the noxious traits of their models (strong mandibles, potent sting, hard integument, venomous secretions) strongly suggest that the spiders are Batesian ant-mimics. The detailed structural and behavioural adaptations enhancing ant-mimicry provide strong circumstantial evidence that the selective agents involved must have good visual acuity, and are probably small insectivorous vertebrates (e.g. birds, lizards and toads) or arthropods (e.g. wasps and spiders) which avoid ants.
Relative impact of roughness and soil texture on mineral dust emission fluxes modeling

Dust production models are widely used to estimate vertical fluxes of 1 mineral aerosols over arid regions. Mineral dust fluxes emitted over western Africa 2 represent one of the largest amount of aerosols in the atmosphere but the emis3 sion calculation remains highly uncertain. Several parameters are involved in the 4 emissions calculations: among others, the surface and soil description is crucial. In 5 atmospheric modeling, depending on the modelled area and the horizontal resolu6 tion, several surface and soil datasets are available and used. Some datasets are built 7 merging satellite data and field campaigns specifically dedicated to this aerosol type: 8 they are generally area limited. Some other datasets are less fine but available for 9 the whole Earth, used for several model applications, including trends and climate 10 studies. In this paper, different surface and soil databases are used to force the same 11 dust production model. Mineral dust fluxes are calculated and compared in term of 12 intensity and spatialization. It is shown that a combination of ERS satellite derived 13 roughness length, of the USGS surface dataset and of the STATSGO-FAO the soil 14 dataset, used with an explicit calculation of drag efficiency enables to estimates re15 alistic mineral dust fluxes when compared to the LISA dataset, used as a reference 16 and built with local measurements and analysis but restricted to the Saharan and 17 Sahel regions. 18
Systematics of the Salmonid Genus Salvelinus Inferred from Ribosomal DNA Sequences

DNA sequences of the second internal transcribed spacer (ITS2) of the nuclear ribosomal DNA were determined for six species of the genus Salvelinus: S. alpinus (Arctic char), S. malma (Dolly Varden), S. confluentus (bull trout), S. leucomaenis (Japanese char), S. fontinalis (brook trout), and S. namaycush (lake trout), and for Hucho perryi (huchen). The ITS2 sequence data (approximately 375 base pairs (bp)) were combined with previously determined sequence data for the ITS1 (approximately 575 bp), giving a total of 981 bp of aligned sequence for each species. Phylogenetic analysis of the aligned sequences was done using maximum parsimony, maximum likelihood, and distance matrix methods with H. perryi as an outgroup. The results were consistent with previous work based on comparisons of morphologies, allozymes, and karyotypes. Comparison of these results with those based on mitochondrial DNA sequences suggests that hybridization may have occurred between S. confluentus and S. alpinus or S. malma.
DeepTMA: Predicting Effective Contention Models for Network Calculus using Graph Neural Networks

Network calculus computes end-to-end delay bounds for individual data flows in networks of aggregate schedulers. It searches for the best model bounding resource contention between these flows at each scheduler. Analyzing networks, this leads to complex dependency structures and finding the tightest delay bounds becomes a resource intensive task. The exhaustive search for the best combination of contention models is known as Tandem Matching Analysis (TMA). The challenge TMA overcomes is that a contention model in one location of the network can have huge impact on one in another location. These locations can, however, be many analysis steps apart from each other. TMA can derive delay bounds with high degree of tightness but needs several hours of computations to do so. We avoid the effort of exhaustive search altogether by predicting the best contention models for each location in the network. For effective predictions, our main contribution in this paper is a novel framework combining graph-based deep learning and Network Calculus (NC) models. The framework learns from NC, predicts best NC models and feeds them back to NC. Deriving a first heuristic from this framework, called DeepTMA, we achieve provably valid bounds that are very competitive with TMA. We observe a maximum relative error below 6%, while execution times remain nearly constant and outperform TMA in moderately sized networks by several orders of magnitude.