Miracle-dz/UniFAR-FTUs huggingface dataset:
The clinical management of bipolar disorder: a review of evidence-based guidelines.

OBJECTIVE To discuss the criteria used to diagnose the mood episodes that constitute bipolar disorder, the approach to the differential diagnosis of these presentations, and the evidence-based treatments that are currently available. DATA SOURCES A search for evidence-based guidelines for the diagnosis and treatment of adults with bipolar disorder was performed on May 5, 2010, using the National Guideline Clearinghouse database, the Agency for Healthcare Research and Quality Evidence Reports database, and the Cochrane Database of Systematic Reviews. In addition, a clinical query of the PubMed database (completed March 1, 2010) and searches of drug manufacturers' Web sites (for unpublished trials) were performed to identify randomized, controlled trials and meta-analyses evaluating strategies to treat resistant depression. STUDY SELECTION Guidelines were selected based on data from randomized, controlled trials; meta-analyses; and well-conducted naturalistic trials that were published since 2005. DATA EXTRACTION Four evidence-based treatment guidelines for bipolar disorder were included. Three were published in 2009: those put forth as part of an Australian project, those of the British Association for Psychopharmacology, and those produced by the International Society for Bipolar Disorders and the Canadian Network for Mood and Anxiety Treatments. The most recent US guidelines are that of the Texas Implementation of Medication Algorithms project, last updated in 2005. DATA SYNTHESIS Recommendations from all 4 guidelines were reviewed and are presented with a focus on using them to improve clinical care. The recommendations with the most agreement and highest level of clinical evidence were as follows: (1) mania should be treated first-line with lithium, divalproex, or an atypical antipsychotic medication; (2) mixed episodes should be treated first-line with divalproex or an atypical antipsychotic; (3) bipolar depression should be treated with quetiapine, olanzapine/fluoxetine combination, or lamotrigine; and (4) all patients should be offered group or individual psychoeducation. Additionally, recommendations for therapeutic drug monitoring are presented due to their importance for patient safety, particularly for the primary care physician, although these are based on consensus guidelines. CONCLUSIONS Bipolar disorder is a lifelong illness that is complicated by high comorbidity and risk of poor health outcomes, making the primary care physician's role vital in improving patient quality of life. The management of acute mood episodes should focus first on safety, should include psychiatric consultation as soon as possible, and should begin with an evidence-based treatment that may be continued into the maintenance phase. Long-term management focuses on maintenance of euthymia, requires ongoing medication, and may benefit from adjunctive psychotherapy.
Recommender System with Composite Social Trust Networks

The development of online social networks has increased the importance of social recommendations. Social recommender systems are based on the idea that users who are linked in a social trust network tend to share similar interests. Thus, how to build an accurate social trust network will greatly affect recommendation performance. However, existing trust-based recommender approaches do not fully utilize social information to build rational trust networks and thus have low prediction accuracy and slow convergence speed. In this paper, the authors propose a composite trust-based probabilistic matrix factorization model, which is mainly composed of two steps: In step 1, the existing explicit trust network and the inferred implicit trust network are used to build a composite trust network. In step 2, the composite trust network is used to minimize both the rating difference and the trust difference between the true value and the inferred value. Experiments based on an Epinions dataset show that the authors' approach has significantly higher prediction accuracy and convergence speed than traditional collaborative filtering technology and the state-of-the-art trust-based recommendation approaches.
Thoracic epidural analgesia compared with patient controlled intravenous morphine after upper abdominal surgery

Twenty–one ASA I or II patients undergoing upper abdominal surgery were studied for 24 hours after operation. They were entered into a prospective, randomised study of patient–controlled intravenous morphine compared with continuous thoracic epidural fentanyl combined with 0.2% bupivacaine. Pain relief was superior in the bupivacaine series (P < 0.05) throughout the 24 hour study period and this was associated with significantly greater pulmonary ventilation compared with the PCA series. Forced expiratory parameters were reduced in both series after the operation but significantly less so in the epidural group. There was a reduced incidence of emetic symptoms in the epidural group (P < 0.05) but the incidence of other minor side effects did not differ significantly. Thoracic epidural fentanyl/bupivacaine results in significantly better analgesia than patient–controlled intravenous morphine.
A coupled network for parasol but not midget ganglion cells in the primate retina

Abstract Intracellular injections of Neurobiotin were used to determine whether the major ganglion cell classes of the macaque monkey retina, the magnocellular-projecting parasol, and the parvocellular-projecting midget cells showed evidence of cellular coupling similar to that recently described for cat retinal ganglion cells. Ganglion cells were labeled with the fluorescent dye acridine orange in an in vitro, isolated retina preparation and were selectively targeted for intracellular injection under direct microscopic control. The macaque midget cells, like the beta cells of the cat's retina, showed no evidence of tracer coupling when injected with Neurobiotin. By contrast, Neurobiotin-filled parasol cells, like cat alpha cells, showed a distinct pattern of tracer coupling to each other (homotypic coupling) and to amacrine cells (heterotypic coupling). In instances of homotypic coupling, the injected parasol cell was surrounded by a regular array of 3–6 neighboring parasol cells. The somata and proximal dendrites of these tracer-coupled cells were lightly labeled and appeared to costratify with the injected cell. Analysis of the nearest-neighbor distances for the parasol cell clusters showed that dendritic-field overlap remained constant as dendritic-field size increased from 100–400 μm in diameter. At least two amacrine cell types showed tracer coupling to parasol cells. One amacrine type had a small soma and thin, sparsely branching dendrites that extended for 1–2 mm in the inner plexiform layer. A second amacrine type had a relatively large soma, thick main dendrites, and distinct, axon-like processes that extended for at least 2–3 mm in the inner plexiform layer. The main dendrites of the large amacrine cells were closely apposed to the dendrites of parasol cells and may be the site of Neurobiotin transfer between the two cell types. We suggest that the tracer coupling between neighboring parasol cells takes place indirectly via the dendrites of the large amacrine cells and provides a mechanism, absent in midget cells, for increasing parasol cell receptive-field size and luminance contrast sensitivity.
A 140W 97%-efficiency 4MHz two-phase buck converter with quasi-square-wave ZVS scheme

This paper presents a high-frequency high-efficiency two-phase buck converter with quasi-square-wave (QSW) ZVS scheme for high-voltage automotive applications. A set of auxiliary inductor and capacitor is shared between two-phase sub-converters to realize ZVS for all power FETs and minimize converter switching power loss under high-voltage and high-frequency conditions. The proposed two-phase structure reduces the required current ripple in the auxiliary inductor, thereby reducing the core loss at high switching frequency. The sizes of the main inductor and the output capacitor are also reduced due to the current ripple cancellation in the two-phase converter. With enhancement-mode GaN FETs, simulation results show that the proposed two-phase QSW-ZVS converter can operate at 4 MHz and achieve peak power efficiency of 97% at a full power of 140 W.
Early and extended early bactericidal activity of linezolid in pulmonary tuberculosis.

RATIONALE Linezolid, the first oxazolidinone approved for clinical use, has effective in vitro and promising in vivo activity against Mycobacterium tuberculosis. OBJECTIVES To evaluate the early and extended early bactericidal activity of linezolid in patients with pulmonary tuberculosis. METHODS Randomized open label trial. Thirty patients with newly diagnosed smear-positive pulmonary tuberculosis (10 per arm) were assigned to receive isoniazid (300 mg daily) and linezolid (600 mg twice daily or 600 mg once daily) for 7 days. Sputum for quantitative culture was collected for 2 days before and then daily during 7 days of study drug administration. Bactericidal activity was estimated by measuring the decline in bacilli during the first 2 days (early bactericidal activity) and the last 5 days of study drug administration (extended early bactericidal activity). MEASUREMENTS AND MAIN RESULTS The mean early bactericidal activity of isoniazid (0.67 log10 cfu/ml/d) was greater than that of linezolid twice and once daily (0.26 and 0.18 log10 cfu/ml/d, respectively). The extended early bactericidal activity of linezolid between Days 2 and 7 was minimal. CONCLUSIONS Linezolid has modest early bactericidal activity against rapidly dividing tubercle bacilli in patients with cavitary pulmonary tuberculosis during the first 2 days of administration, but little extended early bactericidal activity. Clinical trial registered with www.clinicaltrials. gov (NCT00396084).
Glass Ceilings for Ethnic Minorities

We consider glass ceilings for ethnic minorities using Canadian micro-data on the earnings of native-born workers. We see three patterns. First, some groups, such as Chinese-origin people, face more earnings disparity at the top of the conditional earnings distribution than in other parts, like Albrecht et al’s (2003) glass ceiling for Swedish women. Second, some groups, such as Aboriginals, face greater disparity at the bottom than at the top. Third, some groups, such as Caribbean-origin people, have little or no variation in earnings disparity across the quantiles. We interpret these latter patterns as identifying poor access of minority workers to good jobs in various parts of the distribution, rather than as negating a glass ceiling. 1 Department of Economics, Simon Fraser University, pendakur@sfu.ca; Social Development Canada, Government of Canada, ravi_pendakur@sdc-dsc.gc. ca. Krishna Pendakur acknowledges the financial support of the Research on Immigrants and Integration in the Metropolis (RIIM) Center of Excellence. Both authors acknowledge the contributions of our colleagues on this work: Tom Crossley, Brian Krauth, Steeve Mongrain, Simon Woodcock. Finally, we are grateful for the the valuable research assistance of Keerthik Sasidharan.
Profiles of Higher Earning Wives in Hong Kong and the Implications for Marital Satisfaction

Higher earning wives are emerging as a global phenomenon; however, the profiles of higher earning wives and the implications for marital satisfaction remain unknown in Hong Kong. On the basis of a representative household survey of 689 Hong Kong Chinese couples in 2012, this study aimed to explore the profiles of higher earning wives in Hong Kong and examine the effect of wives’ income advantage on the couples’ marital satisfaction. Results indicated that higher earning wives were clustered into 2 groups. One group of higher earning wives was older, was better educated, held managerial and professional jobs, and lived in high-income families compared with lower earning wives. The other group of higher earning wives was not well educated, held nonprofessional jobs, and lived in low-income families. Higher earning wives reported similar marital satisfaction with lower earning wives as well as their husbands. However, higher earning wives with nonprofessional jobs and from low-income families reported lower life and marital satisfaction than did those with better socioeconomic status. The implications of these findings are discussed.
Inhaled corticosteroids decrease vascularity of the bronchial mucosa in patients with asthma

Background Increased vascularity in airway mucosa is a distinctive feature of airway remodelling in asthma. While corticosteroids have proved most effective in modifying airway inflammation, the effect of inhaled corticosteroids on increased airway mucosal vascularity in asthmatics has been little studied.
BRIDGING THE SUPPLY AND DEMAND GAP FOR AFFORDABLE HOME OWNERSHIP IN MALAYSIA: THE ROLES OF GOVERNMENT AND FINANCIAL INSTITUTIONS

Promoting homeownership remains a conundrum in a developing economy in Malaysia. Despite significant initiatives pursued by the government, more needs to be done to promote affordable and sustainable homeownership further. Khazanah Report (2018) provides evidence that housing affordability in Malaysia is worsening compared to one reported in 2015.This study therefore aims to empirically assess the role of government in terms of designing policies to promote the supply of affordable homes and the role of financial institutions in terms of providing home financing. The finding reveals that existing housing policies and government programmes have a significant role in promoting homeownership. The finding further suggests that building and completing more units of affordable homes (as captured by housing stocks) and promoting innovative home financing products (both conventional and Islamic) are the most significant variables in promoting homeownership in Malaysia.
Hydration status assessment by multi-frequency bioimpedance in patients with advanced chronic kidney disease.

INTRODUCTION Body composition assessment has the potential to improve the care of patients with chronic kidney disease (CKD). Whole-body multiple-frequency bioimpedance spectroscopy (BIS) appears to be a useful and appropriate technique for assessing hydration status and body composition in CKD patients. OBJECTIVE The aims of this study were to determine the hydration status by BIS in patients with advanced CKD, and to analyse the association of body fluid status with common clinical and biochemical characteristics. The prognostic value of the phase angle at 50 KHz (PA) was also evaluated. PATIENTS AND METHODS The study group consisted of 175 patients (66 ± 14 year, 77 females) with eGFR < 40 ml/min not yet on dialysis. Body composition was assessed by BIS (BCM, Fresenius). Hydration status was expressed as a percentage of the total body water (TBW). Patients were prospectively followed-up for a median of 481 days, and the main determinants of mortality were estimated by Cox regression analysis. RESULTS The majority of patients (85%) showed a hydration status within ± 5% TBW. Patients with oedemas or uncontrolled arterial hypertension showed mean estimate fluid overload significantly higher than that of the other study patients. Fluid overload was negatively associated with serum albumin levels, body mass index and urinary sodium/potassium ratio; and positively with male gender and diabetes. During the follow-up period, 16 patients died (9%). The main determinants of mortality adjusted for other potential covariates were: Davies comorbidity index (HR = 4.304; P = .001), and PA (per each °; HR = 0.491; P = .026). CONCLUSIONS BIS may help identify changes in hydration status in CKD patients not fully appreciated by clinical or biochemical assessment. PA was a significant predictor of mortality in these patients.
Monolithic millimeter-wave beam control array

A high performance V-band beam control array has been designed, developed and demonstrated. A transmission switch with 24 dB ON/OFF ratio for a single grid and 42 dB ON/OFF ratio (4 dB minimum loss) at /spl sim/62 GHz for a grid pair has been experimentally demonstrated. A 130/spl deg/ reflection phase shift with /spl sim/2.7 dB loss at 60 GHz for a single grid has been successfully obtained. <<ETX>>
Identification of quantum closed systems via the quantum process tomography

The dynamics of an unknown closed quantum system can be characterized by a Hamiltonian. We discuss the identification of this Hamiltonian from quantum process tomography data at several time points for systems with a time-independent Hamiltonian. Quantum process tomography (QPT) yields a set of unitary operators and allows us to convert the identification problem into an estimation problem for the eigenfrequencies of the system. Spectral decomposition of Hermitian and unitary operators shows that process tomography needs to be performed at least at two different time points and the identifiability of the Hamiltonian depends on the choice of these points. Sufficient conditions on the timing to ensure complete identifiability of the Hamiltonian are presented under the assumption that unitary matrices obtained from QPT are exact without numerical errors.
Automatic Monitoring of Software Requirements

Automatic run-time monitoring of software systems’ design/ purchase/ installationtime requirements and assumptions is a key step towards making those systems more robust, maintainable, and self-evolving. A concise language has been designed to permit the convenient expression of a wide range of requirements and assumptions. A compiler automatically converts these expressions into run-time monitors to watch for, and report, all requirement and assumption violations. The mechanism is applicable to systems which have not necessarily been designed with monitoring in mind, permits addition of further requirements and assumption monitoring on-the-fly, and emphasizes usability by a wide range of end-users.
Effect of Audit Quality on Earnings Quality: Evidence From Indonesia Stock Exchange

This research was conducted to test the effect of audit quality on earnings quality. Its observed data consisted of 116 annual data of manufacturing companies listed in the Indonesia Stock Exchange within 2011-2014. The proxies of audit quality are auditor size, audit tenure and audit specialization. The earnings quality was formed from the attributes of accrual quality, persistence, predictability, and income smoothing. The analysis techniques for this research involved (1) an confirmatory factor analysis to form the earnings quality and (2) multiple regression analysis to test the effect of the auditor size, audit tenure and audit specialization on earnings quality. Analysis results showed that earnings quality is formed by the attributes of persistence and predictability. Research results showed that auditor size and audit tenure have effect on earning quality, while audit specialization do not.
Dependence of AMSU-A Brightness Temperatures on Scattering From Antarctic Firn and Correlation With Polarization of SSM/I Data

A function of Advanced Microwave Sounding Unit-A (AMSU-A) measurements at 50.3 and 52.8 GHz is defined, which has the property of being sensitive to the angular distribution of surface-scattered atmospheric thermal emission but insensitive to the surface reflectivity, assuming reflectivity to be equal at the two frequencies. A scattering model consisting of a linear combination of specular reflection and Lambertian scattering is fitted to observed values of the function over Antarctica. The Lambertian fraction typically lies in the range of 0.7-1.0 with a mean of 0.84, and it is negatively correlated with polarization of the surface reflectivity, as determined from Special Sensor Microwave/Imager data. Dual-polarized 37-GHz measurements, combined with a separate measurement of the surface temperature, could be used as a predictor of the diffuseness of surface scattering when the atmospheric temperature profile is retrieved from measurements made by AMSU-A or a similar instrument, or when the radiances are assimilated for numerical weather prediction.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI MANAJEMEN PERUSAHAAN MELAKUKAN TAX PLANNING (Studi Empiris Pada Wajib Pajak Yang Terdaftar Di KPP Madya Makassar)

The aimed of this research is to analized the factors that influence the company management for tax plannning pratical. The respondent of this research were employee at companies listed in KPP Madya Makassar. The data that used in this research was primary data and it was colected by questionnaires. The questionnaires that can be analized was 95 from 110 total distributed questionnaires. The research conducted using quantitative methods and analysis techniques by using multiple linear regression. The result of this research indicated that tax policy, Tax administration, and tax rates have significantly influence to liquifaction of the tax planning. Loopholes was not significantly influence to liquifaction of the tax planning. The result also showed that tax policy, tax administration, loopholes, and tax rates, together (simultaneously) influence to liquifaction of tax planning
Green Human Resource Management in the East and West

The need for paying attention to sustainable development, green issues, and environmental changes is felt more day by day while in green human resource management (GHRM) and greening organizations' human resources are issues paid attention to by different countries seeking to achieve sustainable development and to help preserve the environment. The main purpose of the present study is to perform a systematic review on previously conducted GHRM studies in the east and west during the past ten years. For researchers and managers, this in fact is roughly the best way to share the advantageous information contained by the studies of interest while it also tries to review the findings of various researches in order to signify the similarities and differences that exist in their results, and to underscore the existing gaps. The present research has showed that paying attention to GHRM has significantly increased in east since 2014 while prior to this date, most of the related studies were conducted in the west. For eastern researchers the most interesting functions were respectively education and development (72%), performance management (60%), and rewarding and compensation (56%) as well as other more attention requiring functions including socialization (12%), job analysis (8%), employee retention (8%), and discipline management (4%). On the other hand, the most interesting functions for western researchers were respectively selection and recruiting (61.54%), education and development (53.85%), performance management (53.85%), compensation (53.85%) in addition to other more attention requiring functions including discipline management (0%), socialization (7.69%), employee retention (7.69%), and job analysis (15.38%). The most referred to gaps between the western and eastern studies have turned out to be lack of comprehensive studies in east in addition to the lack of a cross-cultural model which can be utilized for execution of GHRM proportional to the cultures of various different countries. As other gaps in the east it can be referred to cumbersome rules, excessive bureaucracy and hierarchies, lack of managers' support for green plans, and the lack of GHRM training courses, whereas the gaps in the west include lack of comparisons between sustainable and non-sustainable organziations, insufficiency of GHRM related studies, existing of excessive hierarchies in some countries including Brazil, inadequate consideration for the details of GHRM including the manners of absorption of green employees, especially those interested in working with lower wages, and inadequacy of case studies. In the present studies the countries located in Asia are referred to as the east and the countries located in Europe and America continents are referred to as the west.