Miracle-dz/UniFAR-FTUs huggingface dataset:
Coronary vasospasm in ischemic heart disease.

A series of objective documentations indicate the need to reconsider the traditional concept that angina can result only from increased myocardial metabolic demand in the presence of coronary obstruction. A sudden decrease in blood supply may cause transmural or subendocardial ischemia resulting in transient elevation or depression of the ST segment on the ECG. Coronary vasospasm is at present the only convincingly demonstrated cause of reduction of blood supply and it appears to be a common cause of spontaneous angina at rest which occurs in patients with extremely variable degrees of coronary atherosclerosis and is characterized by elevation or depression of the ST segment Other causes of reduction of coronary blood supply, such as platelet aggregation, may also play a role, but so far they could not be demonstrated in man. A provisional pathogenetic classification of angina may be useful for the management of anginal patients: (1) secondary angina, caused by an increase in myocardial demand above the fixed supply that has been limited by coronary atherosclerotic lesions (for which the approach is well-established); (2) primary angina, caused by other coronary or myocardial mechanisms that obviously require different diagnostic and therapeutic approaches. As was the case with hypertension, the classification may become more specific as the causes of primary angina are discovered. In several patients, angina caused by vasospasm coexists with typical secondary angina.
Nucleosome dynamics. II. High flexibility of nucleosome entering and exiting DNAs to positive crossing. An ethidium bromide fluorescence study of mononucleosomes on DNA minicircles.

H2A-H2B exchange with the intranuclear histone pool upon chromatin transcription in vivo is generally viewed as being triggered by the DNA positive supercoiling wave pushed by the elongating polymerase. This notion was tested here by investigating a potential release of H2A-H2B by ethidium bromide-induced positive supercoiling in the loop of mononucleosomes reconstituted on DNA minicircles. The results of gel electrophoresis, fluorescence titration and electron microscopy showed that such a positive supercoiling was not able to release H2A-H2B, nor to unfold the nucleosome to any detectable extent. The reason appeared to be the ease with which the loop could undergo a positive crossing, a surprising observation in view of the DNA left-handed wrapping around the octamer. Moreover, the influence of histone acetylation suggested that such loop flexibility to positive crossing is mediated by histone N-terminal tails which, by interacting with entering and exiting DNAs, reduce their electrostatic repulsion. These conclusions are confirmed and extended in the accompanying article through relaxation with topoisomerase I.
Crouching Tiger, Hidden Dragon: The Laboratory Diagnosis of Severe Acute Respiratory Syndrome

enza pandemic to emerge from southern China, "nature," as always, caught us by surprise. The unusual "atypical" pneumonia, subsequently called "severe acute respiratory syndrome" (SARS), that emerged out of southern China in late 2002 was not caused by influenza, but was, in fact, caused by a novel coronavirus [13]. Epidemiologically, infection with the SARS coronavirus (SARS-CoV) is closely linked with SARS [1, 4], and experimental infection of cynomolgus macaques (Macaca fascicularis) results in pathology reminiscent of the human disease [4, 5]. Human coronaviruses 229E and OC43 are known to be causes of the common cold and have received scant attention, either diagnostically or research wise, in the past few decades. Coronaviruses also cause disease in animals that varies from trans-
Acute Doxorubicin Cardiotoxicity: Functional, Metabolic, and Morphologic Alterations in the Isolated, Perfused Rat Heart

Summary: The acute effects of doxorubicin on coronary perfusion and left ventricular pressures and intracellular phosphate metabolite levels, the latter obtained by 31P nuclear magnetic resonance, were measured simultaneously in isolated, isovolumic rat hearts (Langendorf preparation) perfused at constant flow. Nineteen experimental hearts were perfused for 70 min with oxygenated HEPES-buffered solution containing 6 mg/L doxorubicin. These were compared with 18 control hearts (C), perfused under identical conditions but without doxorubicin, by repeated measures analysis of variance. In the experimental group, coronary perfusion pressure steadily increased to 226.3 ± 13.8% (mean ± SEM) of initial levels (p < 0.0001 vs. C). Because flow was constant, the increase in coronary perfusion pressure in experimental hearts indicates a greater than twofold increase in coronary resistance. Intracellular phosphocreatine and ATP decreased to 80.3 ± 3.9% (p < 0.005 vs. C) and 82.1 ± 6.4% (p < 0.05 vs. C), whereas inorganic phosphate increased to 149.7 ± 19.1% (p < 0.05 vs. C) of initial levels, respectively. Accompanying these changes, diastolic pressure steadily increased to 521.7 ± 91.4% of initial levels (p < 0.0001 vs. C). Developed pressure initially increased to 107.1 ± 4.5% at 30 min, and thereafter decreased to 76.2 ± 6.3% at 70 min (p < 0.05 vs. C). Typical structural alterations in myocyte nuclei were noted. Cellular calcium was not increased in doxorubicin-exposed hearts. Thus, acute doxorubicin cardiotoxicity is characterized by an increase in coronary resistance and is closely correlated with alterations in ventricular function and a decrease in intracellular high-energy phosphate content. These findings suggest that chronic doxorubicin cardiomyopathy may result, in part, from acute hemodynamic and metabolic effects accompanying each drug exposure.
Outcome of low back pain in general practice: a prospective study

Abstract Objectives: To investigate the claim that 90% of episodes of low back pain that present to general practice have resolved within one month. Design: Prospective study of all adults consulting in general practice because of low back pain over 12 months with follow up at 1 week, 3 months, and 12 months after consultation. Setting: Two general practices in south Manchester. Subjects: 490 subjects (203 men, 287 women) aged 18-75 years. Main outcome measures: Proportion of patients who have ceased to consult with low back pain after 3 months; proportion of patients who are free of pain and back related disability at 3 and 12 months. Results: Annual cumulative consultation rate among adults in the practices was 6.4%. Of the 463 patients who consulted with a new episode of low back pain, 275 (59%) had only a single consultation, and 150 (32%) had repeat consultations confined to the 3 months after initial consultation. However, of those interviewed at 3 and 12 months follow up, only 39/188 (21%) and 42/170 (25%) respectively had completely recovered in terms of pain and disability. Conclusions: The results are consistent with the interpretation that 90% of patients with low back pain in primary care will have stopped consulting with symptoms within three months. However most will still be experiencing low back pain and related disability one year after consultation. Key messages It is widely believed that 90% of episodes of low back pain seen in general practice resolve within one month In a large population based study we examined the outcome of episodes of low back pain in general practice with respect to both consultation behaviour and self reported pain and disability While 90% of subjects consulting general practice with low back pain ceased to consult about the symptoms within three months, most still had substantial low back pain and related disability Only 25% of the patients who consulted about low back pain had fully recovered 12 months later Since most consulters continue to have long term low back pain and disability, effective early treatment could reduce the burden of these symptoms and their social, economic, and medical impact
She2p, a novel RNA‐binding protein tethers ASH1 mRNA to the Myo4p myosin motor via She3p

RNA localization is a widespread mechanism to achieve localized protein synthesis. In budding yeast, localization of ASH1 mRNA controls daughter cell‐specific accumulation of the transcriptional regulator Ash1p, which determines mating type switching. ASH1 mRNA localization depends on four independently acting sequences (‘zipcodes’) within the mRNA. In addition, the class V myosin Myo4p and a set of She proteins with as yet unknown function are essential for ASH1 localization. Here we show that She2p is a novel RNA‐binding protein that binds specifically to ASH1 mRNA in vivo and to ASH1 RNA zip codes in vitro. She2p can interact with She3 protein via She3p's C‐terminus and becomes localized to the daughter cell tip upon ASH1 expression. The N‐terminal coiled‐coil domain of She3p is required to form an RNA‐independent complex with the heavy chain of the myosin motor protein Myo4p. She2p and She3p are the first examples of adapters for tethering a localized mRNA to the motor protein and might serve as prototypes for RNA–motor protein adapters.
Preserving the Mental Map using Foresighted Layout

First we introduce the concept of graph animations as a sequence of evolving graphs and a generic algorithm which computes a Foresighted Layout for dynamically drawing these graphs while preserving the mental map. The algorithm is generic in the sense that it takes a static graph drawing algorithm as a parameter. In other words, trees can be animated with a static tree layouter, graphs with a static Sugiyama-style layouter or a spring embedder, etc. Second we discuss applications of Foresighted Layout in algorithm animation and visualization of navigation behaviour.
SUBCELLULAR DISTRIBUTION OF DOPAMINE IN SUBSTANTIA NIGRA OF THE RAT BRAIN: EFFECTS OF γ‐BUTYROLACTONE AND DESTRUCTION OF NORADRENERGIC AFFERENTS SUGGEST FORMATION OF PARTICLES FROM DENDRITES 1

Abstract— The subcellular distribution of dopamine (DA) in substantia nigra from individual male rats was studied with a fractionation procedure on microscale. After differential centrifugation the distribution of DA coincided with that of noradrenaline (NA) which can serve as a marker for synaptosomes in this area. The proportion of DA/NA concentrations was about 1–2 in most fractions. Sixty per cent of nigral DA was found in P2 (17,000 g). When P, was layered on a continuous density gradient, DA and NA peaked at the density of 1.0–1.2 M‐sucrose. Since DA‐containing particles covered a relatively broad range on this gradient, particles between 0.7 and 1.3 M‐sucrose were collected with a discontinuous density gradient. Sixty per cent of DA from P2, was found in this subfraction.
Angiogenesis, multitarget kinase inhibitors and non-small cell lung cancer: a lesson from MONET1 trial.

Angiogenesis, the development and formation of new blood vessels, has been described as one of the hallmarks of cancer, playing an important role in tumor growth, invasion and metastasis (1-4). Several signaling pathways are implicated, such as the vascular endothelial growth factor (VEGF) pathway and platelet-derived growth factor (PDGF) pathway (5). Inhibiting tumor angiogenesis is a therapeutic strategy that has been tested in different solid tumors, including non-small cell lung cancer (NSCLC) (6-8).
Game-theoretic modelling of shared steering control between driver and AFS considering different human-machine goal consistency

Driver-in-the-loop and different human-machine goal consistency should be considered when designing driver-AFS interactive steering control system. In this paper, a novel design approach, namely dynamic game theory is used for the modelling of shared steering control between driver and AFS. Linear Quadratic dynamic optimization approach is used to derive the non-cooperative Nash, non-cooperative Stackelberg, cooperative Pareto equilibrium steering control strategies of the driver and the AFS controller. Two different driving scenarios, where driver's target path has high or low consistency with AFS's are simulated and corresponding simulation results are presented respectively. It was found that different control strategies result in distinct steering behaviors under different driving scenarios. Furthermore, the most interesting simulation result is that using the principle of Stackelberg equilibrium can effectively decrease the steering wheel angle applied by driver in the driving scenario where driver's target path has high consistency with AFS's compared with two other control strategies.
ISPD Peritonitis Recommendations: 2016 Update on Prevention and Treatment

Abstract Peritonitis is a common and serious complication of peritoneal dialysis (PD). Although less than 5% of peritonitis episodes result in death, peritonitis is the direct or major contributing cause of death in around 16% of PD patients (1-6). In addition, severe or prolonged peritonitis leads to structural and functional alterations of the peritoneal membrane, eventually leading to membrane failure. Peritonitis is a major cause of PD technique failure and conversion to long-term hemodialysis (1,5,7,8). Recommendations under the auspices of the International Society for Peritoneal Dialysis (ISPD) were first published in 1983 and revised in 1993, 1996, 2000, 2005, and 2010 (9-14). The present recommendations are organized into 5 sections: 1. Peritonitis rate 2. Prevention of peritonitis 3. Initial presentation and management of peritonitis 4. Subsequent management of peritonitis 5.
Aortic root diameter and risk of cardiovascular events in a general population: data from the PAMELA study

Aim: Data on the association of aortic root diameter (ARD), as assessed by echocardiography, with incident cardiovascular morbidity and mortality in the general population, are scanty and limited to elderly individuals. Thus, we investigated the value of ARD in predicting cardiovascular events in the Pressioni Arteriose Monitorate E Loro Associazioni population. Methods: At entry, 1860 participants (mean age 50 ± 14, 50.6% men) underwent diagnostic tests including laboratory investigations, office and out-of-office blood pressure (BP) measurements (home and 24-h ambulatory BP monitoring), and echocardiography. ARD was measured at the level of Valsalva's sinuses and indexed to body surface area and height. Results: Over a follow-up of 148 months, 137 nonfatal or fatal cardiovascular events were documented. After adjustment for age, sex, BP, fasting blood glucose, total cholesterol, smoking status, previous cardiovascular disease, and use of antihypertensive drugs, ARD/height [hazard ratio for 1 unit increase = 2.62, 95% confidence interval (CI) 1.19–5.75, P = 0.01], but not absolute ARD (hazard ratio 1.44, 95% CI 0.89–2.39, P = 0.13) neither ARD/body surface area (hazard ratio 2.09, 95% CI 0.96–4.55, P = 0.06) predicted the increased risk of cardiovascular events. The association between left ventricular hypertrophy and AR dilatation was a stronger predictor of cardiovascular prognosis than left ventricular hypertrophy alone. Conclusions: Our results for the first time show that ARD indexed to height is predictive of incident nonfatal and fatal cardiovascular events among middle-aged individuals in the community and support the view that assessment of ARD in addition to left ventricular mass may refine cardiovascular risk stratification and preventive strategies in the general population.
Where do rodents fit? Evidence from the complete mitochondrial genome of Sciurus vulgaris.

*Centro Studio Mitocondri e Metabolismo Energetico, Consiglio Nazionale delle Ricerche, Bari, Italy; †Dipartimento di Biochimica e Biologia Molecolare, Universita di Bari, Bari, Italy; ‡Dipartimento di Fisiologia e Biochimica Generali, Universita di Milano, Milano, Italy; §Laboratoire de Paleontologie, Paleobiologie et Phylogenie, Institut des Sciences de l’Evolution, Centre National de la Recherche Scientifique, Universite Montpellier II, Montpellier, France
Plesiomonas shigelloides bacteremia in a healthy girl with mild gastroenteritis

A previously healthy 15-year-old girl fell ill with febrile gastroenteritis; Plesiomonas shigelloides was isolated from the blood 6 h after she had received one tablet of trimethoprim-sulfadiazine on the third day of symptoms. She recovered uneventfully. P. shigelloides may be isolated from the blood in immunocompetent patients with mild, uncomplicated gastroenteritis.
Load pseudomeasurements in distribution system state estimation

Distribution system state estimation (DSSE) is an essential tool in active distribution grids in order to enhance the awareness of the power system operators regarding the state of the distribution system. One of the peculiarities of the DSSE is the lack of adequate real-time measurements. Thus, in this paper a three-phase DSSE algorithm enhanced with an advanced approach for modeling pseudomeasurements is proposed. The major innovation of the proposed methodology is the development of a DSSE algorithm based on limited real-time measurements. The proposed DSSE algorithm takes into account the unbalanced nature of the distribution systems and the presence of virtual measurements. The pseudomeasurements are obtained from historical data, through a Gaussian Mixture Model (GMM) methodology, improved by the Calinski & Harabasz (CH) criterion and the Expectation Maximization (EM) algorithm. The performance of the proposed methodology is illustrated on the IEEE 13 node test feeder and compared with the case where the pseudomeasurements are modeled through a normal distribution.
Local Semicircle Law for Random Regular Graphs

We consider random d‐regular graphs on N vertices, with degree d at least (log N)4. We prove that the Green's function of the adjacency matrix and the Stieltjes transform of its empirical spectral measure are well approximated by Wigner's semicircle law, down to the optimal scale given by the typical eigenvalue spacing (up to a logarithmic correction). Aside from well‐known consequences for the local eigenvalue distribution, this result implies the complete (isotropic) delocalization of all eigenvectors and a probabilistic version of quantum unique ergodicity. © 2017 Wiley Periodicals, Inc.
The association between daily blood pressure and catecholamine variability in normotensive working women.

&NA; Using ambulatory blood pressure monitors and timed urine collection techniques, blood pressure and the rates of urinary catecholamine excretion were compared across the work, home, and sleep environments of 45 women who perceived their work environment as most stressful (work stressed) and 35 women who perceived their home environment as equally or more stressful (home stressed) on the day of monitoring. The work‐stressed women had higher systolic pressure at work (121 vs. 115; p < 0.05). There were no significant differences in diastolic pressure or the absolute levels of the catecholamines between the groups. However, the percent changes in blood pressure and catecholamines from work or home to sleep were significantly correlated in the work‐stressed but not the home‐stressed women (r values from 0.25 to 0.45, p < 0.05). The work‐stressed and home‐stressed women differed in their proportional make‐up of several demographic characteristics, including having children (percentage of home‐stressed women with children > work‐stressed) (p < 0.05), ethnicity (percent of black home‐stressed > work‐stressed) (p < 0.01), and family history of hypertension (percentage of work‐stressed > home‐stressed) (0.05 < p < 0.10). These differences, in part, may have determined the daily patterns of perceived stress in the two groups of women. Overall, these findings suggest that work stress and/or the sociodemographic characteristics that may influence the perception of work stress may drive a daylong sympathetic response that increases blood pressure in working women.
Effect of yogic exercises on symptoms of musculoskeletal disorders of upper limbs among computer users: a randomised controlled trial.

BACKGROUND AND OBJECTIVES Upper extremity musculoskeletal disorders (MSD) are very common in regular computer users and leading cause of work related illness. The objective of the present study is to evaluate effectiveness of yogic exercises in the improvement of symptoms of MSDs of upper limbs. MATERIALS AND METHODS 60 study participants were randomly divided into two groups that is yoga with counselling and only counselling group for 12 weeks. Symptom severity and functional status were assessed using the self administered Boston Carpal Tunnel Questionnaire and predesigned symptom questionnaire before and after intervention. RESULTS There was significant reduction in symptom severity score (P = 0.002) and improvement in functional status score in yoga with counselling group when compared to only counselling group. There is also a significant decrease in self reported symptoms like CT myalgia symptom (P = 0.019) and improvement in weakness. CONCLUSION The present study showed a yoga based regimen is more effective than counselling alone in relieving symptoms of computer related musculoskeletal disorders.
Article in press-uncorrected proof Review Translating pharmacogenetics into clinical practice : interleukin ( IL ) 28 B and inosine triphosphatase ( ITPA ) polymophisms in hepatitis C virus ( HCV ) infection

Hepatitis C virus (HCV) infection is frequently characterized by evolution to chronicity and by a variable clinical course of the disease. The clinical heterogeneities of HCV infection and the imperfect predictability of the response to interferon (IFN) have suggested the need to search for a genetic basis of clinical features. This led to the discovery of genetic polymorphisms playing a major role in the evolution of infection, as well as on treatment response and adverse effects. This review will cover recent reports on the subject, focusing on the potential use of the new genetic markers in the diagnostic algorithm for the stratification of patients for personalized antiviral regimens.
Experimental results of an AMC antenna fabricated with a magnetically-loaded elastomeric substrate

Experimental results are shown for low profile bent-wire monopole antennas fabricated on artificial magnetic conductors (AMCs) that contain homogeneous magnetically-loaded elastomeric substrates. The elastomeric substrate is a lower cost and lighter weight alternative to the use of ferrite tiles. A 900 MHz antenna with a 20% return loss bandwidth and 40% antenna efficiency is described.