Miracle-dz/UniFAR-FTUs huggingface dataset:
Transglutaminases are a group of enzymes that catalyze the covalent conju- gation of amines to protein-bound glutamine residues. The products of transglu- taminase activity are proteins covalently cross-linked by ~-(3"-glutaminyl)-lysine isopeptide bonds and proteins containing covalently conjugated

Transglutaminases are a group of enzymes that catalyze the covalent conjugation of amines to protein-bound glutamine residues. The products of transglutaminase activity are proteins covalently cross-linked by ~-(3"-glutaminyl)-lysine isopeptide bonds and proteins containing covalently conjugated polyamines (16). Several distinct intracellular and extracellular transglutaminases have been identified (1, 2). The predominant form of this enzyme in liver and cultured fibroblasts is tissue transglutaminase, an ~80,000 D polypeptide (2, 7-9). We have measured the amounts of this enzyme in a variety of normal and transformed cell types and have found that macrophages can contain extremely high levels (9). Studies from several laboratories have indicated that transglutaminase may play an important role in macrophage function. Activation of guinea pig and mouse macrophages in vivo is associated with marked increases in transglutaminase activity due to a dramatic induction of tissue transglutaminase (9-11). In both cell types, elevated levels of transglutaminase activity have been correlated with enhanced Fc receptor-mediated phagocytic capacity (10-12). Furthermore, several inhibitors of transglutaminase activity block phagocytosis of immune complexes and opsonized erythrocytes (1 1, 12). However, the precise role of transglutaminase in macrophage function remains to be determined. Peripheral blood monocytes can differentiate into macrophages when cultured in vitro (13-18). The differentiation of myelobastic cells into macrophages has been associated with marked increases in the levels of transglutaminase (10, 19). Therefore, we were interested in determining the level of tissue transglutaminase in peripheral blood monocytes and if differentiation of these cells into macrophages was associated with alterations in the level of the enzyme. We report here that the levels of tissue transglutaminase in freshly isolated human peripheral blood monocytes are very low but that the enzyme accumulates to significant levels during culture of these cells in vitro. This work was supported in part by grant AM27078 from the National Institutes of Health, grant BC334A from the American Cancer Society, and by a grant from the Kroc Foundation. * To whom correspondence should be addressed at the Department of Pharmacology, University of Texas Medical School, P.O. Box 20708, Houston, TX 77025. * Current address is the Division of Rheumatology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262.
Hemodynamic Differences between Propofol-Remifentanil and Isoflurane-Remifentanil Anesthesia for Repair of Cleft Palate in Children

Background: Cleft palate repair is associated with hemorrhage and hemodynamic changes in children. This study aimed to compare hemodynamic changes during cleft palate repair in patients anesthetized with isoflurane-remifentanil versus propofolremifentanil. Methods: In this randomized, double blind clinical trial, 100 cleft palate repair candidates who aged under three years were allocated to two groups of 50 to receive either isoflurane-remifentanil or propofol-remifentanil for maintaining anesthesia. Results: The mean systolic and diastolic blood pressure and the mean arterial pressure were significantly lower in the propofol-remifentanil group (P<0.001). The mean extubation time (P<0.001), time to first analgesic administration (P: 0.04), and recovery time (P<0.001) were significantly longer in the isoflurane-remifentanil group. Conclusion: Propofol-remifentanil-based anesthesia caused more stable hemodynamic state in patients undergoing cleft palate repair. The mean systolic and diastolic blood pressure, as well as the mean arterial pressure, was lower with propofol-remifentanil administration. Therefore, this combination can lower the risk of intraoperative hemorrhage. J Pharm Care 2018; 6(1-2): 23-28. ► Please cite this paper as: Shafa A, Habibzadeh MR, Seyedmohammadi B. Hemodynamic Differences between Propofol-Remifentanil and Isoflurane-Remifentanil Anesthesia for Repair of Cleft Palate in Children. J Pharm Care 2018; 6(1-2): 23-28. Introduction Cleft palate is a common birth defect characterized by the opening of the roof of the mouth into the nose. Occurring either alone or in combination with a cleft lip, a cleft palate can cause breastfeeding and hearing problems, frequent ear infections, and impaired speech. The best time for cleft palate repair surgery is between nine and 18 months of age (1). Cleft palate repair is a long procedure associated * Corresponding Author: Dr Mohammadreza Habibzadeh Address: Department of Anesthesiology and Intensive Care, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. Tel: +989133891027. Fax:+983136684510. Email: gsmhabibzadeh@yahoo.com with a high risk of bleeding. Moreover, considering the patients’ age, it is of paramount importance to maintain hemodynamic stability (1, 2) and minimize bleeding through various methods such as controlled hypotension using remifentanil (3, 4). Remifentanil is a potent, shortacting narcotic (twice as potent as fentanyl) metabolized by esterase. The drug is administered at a dosage of 0.11. 0 μg/kg/min in combination with an anesthetic (3). Isoflurane and propofol are anesthetic agents used to maintain anesthesia. Isoflurane is a halogenated inhalation anesthetic metabolized by the liver. It exerts its effects by interfering with the physiological activities of neuronal membranes in the brain (5). Propofol is an intravenous anesthetic metabolized by the liver. It acts by jpc.tums. ac.ir
Experimental and Computational Analysis of Chloroplast Transit Peptide Domain Architecture and Function

The Majority of chloroplast proteins are nuclear-encoded and utilize an Nterminal transit peptide (TP) to target into chloroplasts via the general import pathway. Bioinformatic and proteomic analyses provide thousands of predicted TPs, which show low sequence similarity. How the common chloroplast translocon components recognize these diverse TPs is not well understood. Previous results support either sequenceor physicochemical-specific recognitions. To further address this question, a reverse sequence approach was utilized such that the reverse TP contains the same amino acid composition as wild-type TP but lack similar sequence motifs. Using both native and reverse TPs of the two well-studied precursors, we explored these two modes of recognition. We found that reverse TPs behaved similar to wild-type TPs during binding but failed to support protein translocation. We further showed the importance of the Nterminal domain of TPs in governing protein translocation into plastids. When the TP N-termini were replaced with unrelated peptides with varying Hsp70 affinities, we showed that a subset of TP N-termini functions as Hsp70interacting domains. We proposed that these domains interact with the stromal motor Hsp70. We further identified a conserved spacer distance between these Nterminal Hsp70 domains to the translocon receptor Toc34 binding sites called FGLK motifs. Using mutants with varying spacer lengths, we observed that the most efficient translocation occurred only at an optimal spacer length of around 28 to 31 aa. These results led us to propose the bimodal interaction model of TP architecture and function where a TP contains an N-terminal stromal interacting domain that is linked to a Toc interacting domain via an optimal spacer length. This configuration permits a temporal and/or spatial coupling between a "capturing step" by a TOC receptor and a "trapping/pulling" step by a stromal ATP-dependent molecular motor that is required for productive translocation.
Analysis of hearing improvement following fat graft myringoplasty

Background: Fat graft myringoplasty (FGM) is a procedure with a short learning curve, cost effective, with minimal morbidity in properly selected patients. It is useful to relieve the patient of annoyance caused by a small perforation in terms of ear discharge and hearing loss. The aim was to assess postoperative hearing improvement and investigate influence of factors like age, gender and location of perforation on audiological outcomes.Methods: This study was a prospective study done on 25 patients at a tertiary care hospital who underwent FGM. All patients had small dry central perforation. Air and Bone conduction (AC/BC) thresholds and air-bone gap (ABG) were evaluated both preoperatively and postoperatively. Results: Mean hearing improvement was 14.4762 dB in <40 yrs age group whereas it was 11.2500 dB in >40 yrs age group. Mean hearing improvement in females was 13.75 dB whereas it was 14.154 dB in males. Mean hearing improvement was 15 dB in posterior, 14.7 dB in inferior and 14.46 dB in anteriorly located perforation.Conclusions: FGM is effective in improving postoperative hearing thresholds hence it can be used in small dry central perforations of tympanic membrane in patients irrespective of patient variables such as age, gender, and location of perforation. As no significant statistical difference was observed in terms of gender, location or aetiology of perforation, we consider it a procedure to be recommended across all spectrums of patients.
Methods for Respecting Political Subdivisions, in Automated Redistricting

This project presents new methods for automated legislative districting. Recent efforts in this vein have focused primarily on the goals of equipopulation, contiguity, and spatial compactness, and on the implications for political parties. Lawmakers and lawyers have long recognized the additional objective of reducing the division of existing political communities. This project demonstrates that existing work can be adapted to capture that additional aim, using simple geometric manipulations of the underlying geometry. In short, scaling communities or their perimeters elevates ju-risdictional divisions into physical space. This manipulation makes it possible to use existing optimization methods to minimize the division of communities. An empirical exercise demonstrates that the scaling approach provides an eﬀective sliding scale for reducing the division of existing communities, in this case counties. The scaling does not aﬀect the outcomes expected for the dominant political parties; the choice of scaling value is not a hidden partisan choice. The project thus extends the objectives that algorithms can be used to optimize. Districting reform at the Federal level in the United States has long focused on the courts, but the Supreme Court’s decision in Rucho v.Common Cause foreclosed the possibility of Federal, judicial relief. Congress has the explicit constitutional authority to regulate gerrymandering and a long history of doing so. This project seeks to revive and inform that approach.
“Assessing the compatibility of management behavior and entrepreneurial orientation”

The paper uses a data set on a Dutch company of which the partners – who act as managers and entrepreneurs – have assessed both themselves and their peers on dimensions of De Waal’s High Performance Management framework. Two of these dimensions relate to Management Behavior (MB) and Entrepreneurial Orientation (EO). The research addresses the question whether the theoretical differences between MB and EO (inward versus outward looking; short versus long term; directly or not directly affecting others; specific versus abstract) are reflected by differences in the predictive power of one’s self-assessment on the assessment of one’s peers. The authors’ findings indicate that MB and EO assessments are uncorrelated; and related to self-assessments in different manners. MB follows the assessment patterns that can be expected among chess players where the skills of the evaluator predict how they evaluate their peers. EO in contrast follows the pattern that can be expected in the popular game of soccer where even unskilled spectators are able to assess the players. In MB, self-assessments by evaluees are poor predictors of how they are evaluated by their peers. In EO the reverse holds: self-assessments by evaluees predict their evaluations by peers (and therefore, these self-assessments are informative). The authors argue that the differences between MB and EO have organizational consequences. MB is subject to processes of learning and adaptation, and therefore any differences within management teams can be overcome. Since team members will not easily disagree on each other’s EO related skills, weaknesses are taken for granted and may cause an entrepreneurial stalemate with no improvement.
Assessment of Heavy Metals and Natural Radionuclides Accumulation for Marine Organisms at Alexandria, Egypt

The present study aims to quantify the distribution of some heavy metals (Pb, Cd, Ni, Mn, Cr, Cu, Co and Zn ions) and natural radionuclides (U-series, Th-series and K) in some marine organisms and water samples in the Alexandria Mediterranean Sea coastline. As well as assessment the heavy metals impacts and the radiological impacts of the detected radionuclides on Marine organism. Five locations are selected for this study and they are El-Mex, Eastern Harbour, El-Dekhila, Abu-Qir and Rashid. The investigated marine organisms areFish (Engraulisencrasicolus), Sepia Officianalis, Crabs, Diatom Amphora, Om-Elkhlol "Donaxtrunculus, and Gandofelly" Tapes decussates. Determination of heavy metals in the investigated organisms and water samples has been carried out using atomic absorption spectrophotometer. Also the laboratory investigations for radionuclides in the organism and the water samples have been carried out using a HpGe gamma ray spectrometric technique. The seawater samples in all studied locations have very high concentration of Zn and Mn ions, and the concentrations of the investigated heavy metal ions have the following order: Zn> Mn> Pb> Co> Cr> Cu> Ni> Cd. In all locations, the concentrations of Cr ions nearly coincident with that of worldwide average values, while other heavy metal ions are very high than the worldwide average values, USEPA. The concentrations of heavy metals in the investigated marine organisms discernthat Mn ions do not accumulated in any investigated marine organisms in compared to worldwide average values by the USEPA. Fish (Engraulisencrasicolus), Sepia OfficianalisandOm-Elkhlol "Donaxtrunculusareable to highly accumulate Ni and Co ions. Crab and Diatom Amphoraareable to highly accumulate Pb, Cd, Ni, Cr and Co ions.Cu ions do not accumulate in any investigated marine organism except Diatom Amphora in Rashid and Abu-Qir locations. Diatom Amphorais able to accumulate Zn ions than any investigated marine organisms. High levels of U-series, Th-series and K in water samples are recorded in Rashid location and they equal 15.71±0.83, 13.8±1.27 and 185.8±8.42 mBq/l, respectively. Also in this location Fish Engraulisencrasicolus has high level of U equals 55mBq/kgbut Sepia Officianalis has high level of both Uequals 34 mBq/kgand Th equals 35 mBq/kgas well as the Diatom Amphora record high activity of Kequals 340±19mBq/kg, than other organisms. Bioconcentration factors (BCF) of the investigated heavy metals and radionuclides for the studied organisms were calculated. The investigated marine organisms have bio-accumulative properties towards most of the investigated heavy metals and radionuclides. The concentration levels of the heavy metals found in this study do not constitute a risk factor for the marine organisms and appear to be accommodating with the worldwide values by the USEPA. Concentrations of U-series, Th-series and K in both water and marine organisms are accommodate with worldwide values.
CAPITAL ACCUMULATION, SAVINGS AND ECONOMIC GROWTH OF A NATION – EVIDENCE FROM NIGERIA

This study examines the problem of low savings and capital accumulation as it relates to economic growth in Nigeria. Addressing some of the methodological issues, underlying these macroeconomic aggregates, as well as identifying policy implications of the linkage between savings, capital accumulation and growth in Nigeria, The study covers a period of thirty-three years starting from 1980 to 2012. The study employed savings model, investment model and Growth model. Savings model shows that investment and gross domestic product have a positive and significant effect on savings in Nigeria while, inflation has a negative and insignificant effect on savings in Nigeria. Lending rate has a positive but insignificant effect on savings. Savings has a positive and significant effect on investment in Nigeria, investment has a positive but insignificant effect on economic growth while savings has a positive and significant effect on economic growth in Nigeria. It is recommended that, Particular attention should be paid to economic and sociocultural shocks specifically, the investment climate and policies must be put in place to curb inflation in Nigeria so as to ensure macroeconomic stability and economic development.
QUALITY MANAGEMENT IN UNDERGRADUATE EDUCATION FROM THE PERSPECTIVE OF SCHEIN'S CAREER ORIENTATIONS INVENTORY

The purpose of this paper was to reveal the link between the human resource profile of the school education and profiles described by Schein in terms of education quality management. The Career Orientations Inventory was applied in order to emphasize the link between profit and quality of human resources. Education and training providers are at the base of the education and training system in that they are the organizations that actually engage in teaching and learning and deal directly with learners. It is therefore of great importance that providers develop quality management systems (QMS)
Examining the Content Load of Part of Speech Blocks for Information Retrieval

We investigate the connection between part of speech (POS) distribution and content in language. We define POS blocks to be groups of parts of speech. We hypothesise that there exists a directly proportional relation between the frequency of POS blocks and their content salience. We also hypothesise that the class membership of the parts of speech within such blocks reflects the content load of the blocks, on the basis that open class parts of speech are more content-bearing than closed class parts of speech. We test these hypotheses in the context of Information Retrieval, by syntactically representing queries, and removing from them content-poor blocks, in line with the aforementioned hypotheses. For our first hypothesis, we induce POS distribution information from a corpus, and approximate the probability of occurrence of POS blocks as per two statistical estimators separately. For our second hypothesis, we use simple heuristics to estimate the content load within POS blocks. We use the Text REtrieval Conference (TREC) queries of 1999 and 2000 to retrieve documents from the WT2G and WT10G test collections, with five different retrieval strategies. Experimental outcomes confirm that our hypotheses hold in the context of Information Retrieval.
Subtype-specific differences in the risk of hospitalisation among patients infected with hepatitis E virus genotype 3 in Belgium, 2010 – 2018

Some European countries recently reported an increase in hepatitis E virus genotype 3 (HEV-3) of the subtype 3c. No link between HEV-3 subtypes and severity is established to date. Here, we report that patients infected with HEV-3c were at lower risk of hospitalisation, compared to those infected with HEV-3f, the other main subtype circulating in Belgium.
Study of mitochondrial DNA (mtDNA) D - loop region polymorphism in Şavak Akkaraman sheep

This study was conducted to investigate the maternal genetic diversity using the mtDNA D - loop region 842 base pair bp polymorphism in Şavak Akkaraman sheep raised in the province of Erzincan. According to the results, in the mtDNA D - loop of the Şavak Akkaraman breed, 27 polymorphic sites and 20 haplotypes were identified and then, 11 of the 20 haplotypes identified in Şavak sheep were in haplogroup B 55% , 6 in haplogroup A 30% , and 3 in haplogroup C 15% . Haplogroup B was the most frequent haplogroup in Şavak Akkaraman sheep. Haplotype and nucleotide diversities were estimated to be 0.995 ± 0.004 and 0.0146 ± 0.0003, respectively. The Şavak Akkaraman breed was compared with the mtDNA sequencing of different breeds and wild sheep, and the contribution of the breed to biodiversity was considered.
Efficient 4-Way Vectorizations of the Montgomery Ladder

We propose two new algorithms for 4-way vectorization of the well known Montgomery ladder over elliptic curves of Montgomery form. The first algorithm is suitable for variable base scalar multiplication. In comparison to the previous work by Hisil et al. [17] , it eliminates a number of non-multiplication operations at the cost of a single multiplication by a curve constant. Implementation results show this trade-off to be advantageous. The second algorithm is suitable for fixed base scalar multiplication and provides clear speed improvement over a previous vectorization strategy due to Costigan and Schwabe (2009). The well known Montgomery curves Curve25519 and Curve448 are part of the TLS protocol, version 1.3. For these two curves, we provide constant time assembly implementations of the new algorithms. Additionally, for the algorithm of Hisil et al. [17] , we provide improved implementations for Curve25519 and new implementation for Curve448. Timings results on the Haswell and Skylake processors indicate that in practice the new algorithms are to be preferred over previous methods for scalar multiplication on these curves.
CHARACTERIZATION AND UTILIZATION OF PSYLLIUM HUSK FOR THE PREPARATION OF DIETETIC COOKIES

Present research was carried out to characterize and utilize psyllium husk for preparation of dietetic cookies. Straight grade flour was replaced with psyllium husk in different combinations @ 5, 10, 15, 20 and 25%. Regarding characterization of psyllium husk, mean values obtained for moisture, ash, crude protein, crude fat, crude fiber and nitrogen free extract (NFE) in husk were 6.43±0.05, 3.85±0.04, 2.08±0.06, 0.09±0.01, 3.83±0.02 and 83.72±0.08%, respectively. Moreover, total dietary fiber and arabinoxylan content were 76.63±1.32 and 46.71±2.14%, respectively. Physical characteristics of dietetic cookies i.e. diameter and spread ratio were diminished with the addition of husk while thickness was increased. Results regarding storage of the cookies showed increase in diameter and spread ratio whilst thickness depicted decreasing trend. Chemical assay revealed higher crude protein content in control cookies. Whereas, moisture, ash, crude fiber, NFE along with dietary fiber and arabinoxylan contents were higher in psyllium husk based cookies. Softer cookies with low gross energy were obtained with the addition of psyllium husk. Conclusively, psyllium husk based cookies showed gradual enhancement in dietary fiber content as the amount of husk was increased in the recipe. The resultant cookies may have potential to manage the lipid profile and glucose concentrations in human subjects.
Kolmogorov and Zabih's Graph Cuts Stereo Matching Algorithm

Binocular stereovision estimates the three-dimensional shape of a scene from two photographs taken from different points of view. In rectified epipolar geometry, this is equivalent to a matching problem. This article describes a method proposed by Kolmogorov and Zabih in 2001, which puts forward an energy-based formulation. The aim is to minimize a four-term-energy. This energy is not convex and cannot be minimized except among a class of perturbations called expansion moves, in which case an exact minimization can be done with graph cuts techniques. One noteworthy feature of this method is that it handles occlusion: The algorithm detects points that cannot be matched with any point in the other image. In this method displacements are pixel accurate (no subpixel refinement).