Miracle-dz/UniFAR-FTUs huggingface dataset:
Mechanotransduction and ion transport of the endothelial glycocalyx : a large-scale molecular dynamics study

In our vessels, the endothelial glycocalyx is the first and foremost barrier directly exposed to the blood in the lumen. The functions of the normal endothelial glycocalyx under physiological conditions are widely accepted as a physical barrier to prevent the abnormal transportation of blood components (e.g. ions, proteins, albumin and etc.) and a mechanosensor and mechanotransducer to sense and transmit mechanical signals from the blood flow to cytoplasm. In this study, a series of large-scale molecular dynamics simulations were undertaken to study atomic events of the endothelial glycocalyx layers interacting with flow. This research is a pioneer study in which flow in the physiologically relevant range is accomplished based on an atomistic model of the glycocalyx with the to-date and detailed structural information. The coupled dynamics of flow and endothelial glycocalyx show that the glycocalyx constituents swing and swirl when the flow passes by. The active motion of the glycocalyx, as a result, disturbs the flow by modifying the velocity distributions. The glycocalyx also controls the emergence of strong shear stresses. Moreover, flow regime on complex surface was proposed based on results from a series of cases with varying surface configurations and flow velocities. Based on the dynamics of subdomains of the glycocalyx core protein, mechanism for mechanotransduction of the endothelial glycocalyx was established. The force from blood flow shear stress is transmitted via a scissor-like motion alongside the bending of the core protein with an order of magnitude of 10~ 100 pN. Finally, the mechanism of flow impact on ion transport was investigated and improved Starling principle was proposed. The flow modifies sugar chain conformations and transfers momentum to ions. The conformational changes of sugar chains then affect the Na+/sugar-chain interactions. The effects of flow velocity on the interactions are non-linear. An estimation in accordance to the improved Starling principle suggests that a physiological flow changes the osmotic part of Na+ transport by 8% compared with stationary transport.
Moving the needle towards health equity: A policy-driven transdisciplinary approach to address health disparities for vulnerable communities

Objectives: Policymakers, health services researchers, community leaders and health care delivery organisations are key stakeholders in addressing economic, environmental, social and systemic barriers to health equity in vulnerable communities. However, they often operate in silos, leaving gaps in efforts to effectively address health disparities. It is important to develop a new approach to influencing responsive health equity–focused policies. Design: An innovative, collaborative model is outlined that leverages strengths across these four stakeholders to reduce inequity in target populations. The model brings together undergraduate and graduate student researchers in a front-end policy partnership with elected officials based on mutually agreed-upon commitment to address local health disparities impacting the policymaker’s constituency. Setting: Students and faculty at Arizona State University partnered with the office of a Phoenix City Council member representing a constituency largely comprised of low-income and Hispanic community members. Method: Relationships were developed with the policymaker specifically targeting food insecurity and paediatric asthma. Graduate student researchers conducted academic placements within the elected official’s office, attended relevant municipal meetings, engaged with local community-based organisations and partnered with a major academic medical centre to collect data and understand current efforts related to the two focus areas. Results: Elected officials were provided with a policymaker-tailored toolkit including a current state analysis, stakeholder assessment and recommendations for action. Collective discussion took place concerning the strengths and limitations of stakeholders’ ability to improve population health and present findings from the model’s first application to local government. Conclusion: By ensuring ‘buy-in’ from policymakers at the onset of collaboration, stakeholders worked as a transdisciplinary team to translate academic research into actionable policy to benefit high-need communities. This model adopted can potentially accelerate and improve the development and implementation of actionable policies, thereby increasing social capital and building relationships with policymakers to address the root causes of health inequities.
Effect of Cow Parity and Calf Characteristics on Milk Production and Reproduction of Friesian Dairy Cows

Viability and profitability of livestock enterprise is evaluated by the percentage of pregnant females over a period of time after exposure to bulls and amount of milk yield per lactation. This attribute was tested using 20 seven-month in calf Friesian dairy cows. Effect of parity on; gestation period, calf birth weight, milk production, lactation length, and postpartum heat were tested in this study. Effect of calf sex and calf birth weight on milk production and postpartum heat of the dam was also studied. Parity highly influenced gestation period with Cows at parity 4 taking significantly the least number of days (269.5 days). The cows at parity 4 delivered calves that recorded the highest calf birth weight mean (39.0 kg). Milk production per day was significantly higher in the cows at parity 4 (17.0 L). There was significant positive correlation (r 2 =0.86, P<0.001) between milk production and time to taken to exhibit postpartum heat Calf birth weight highly influenced milk production with dams of heavier calves producing significantly more milk than dams of lighter calves. Dams of heavier calves had significantly delayed postpartum heat. Calf sex significantly influenced milk production and postpartum heat. There was significant (r 2 =0.79, P<0.001) positive correlation between calf birth weight and time to postpartum heat. Adoption and use of these findings will improve dairy industry through reducing calving intervals. Calf Birth weight should be used as important traits in performance testing of dairy cattle. Keywords : parity, Friesian cow, milk production DOI : 10.7176/JNSR/9-10-06 Publication date :May 31 st 2019
Which older adults refuse to or dropout from participation in a trial of integrated care in Singapore and why? Insights from quantitative and qualitative data

Study Objectives: Clinical trials with frail older adults are associated with low recruitment rates and high dropout rates. A review of major funded UK trials found that less than one-third recruited their original target within the time originally specified [1]. This paper aims to examine the recruitment and dropout rates of frail older Singaporeans in a trial of a three year integrated care program (EPICC). Methodology: The target was to recruit 80 frail patients aged 60+ prior to SGH and AH acute care discharge and randomly assigned to two arms, over four months. Logistics and administrative procedures for recruitment were studied. Profiles of recruited and dropout patients were collected. If patients refused to participate in the recruitment or were recruited and then dropped out, they were asked their reasons for doing so. Results: 113 patients had to be recruited over 13 months in order to meet the original target. Reasons for non-participation (n=37) included patients had difficulty understanding why there should be clinical trials in elder care (35.1%); ineligibility due to incorrect frailty assessment (27%); patients were on the nursing home waiting list (13.5%). Conclusion: Improved logistics and administrative procedures for recruitment in acute care; and effective communication with older patients will decrease exclusion of older adults from clinical research.
Innovation in the user interface design process

Innovation is crucial to the success of the products and services that high-technology companies develop. Innovation in user interfaces is especially important since the user interface often defines a product or service in the customer's mind. However, introducing innovation can add costs in terms of additional development time, lower reliability, and poorer standardization. Thus, tradeoffs must be made with regard to innovation in the development of commercial products and services. Little is known about how innovations are conceived and introduced into user interfaces. If we can analyze innovation in user interface design, then there is potential for improving the design process so that the costs of achieving innovation can be reduced. As a first step in this direction, several user interface designers were interviewed to determine how they achieve innovation in their work. An analysis of the designers' comments is presented, including a five-stage model of the user interface innovation process. Suggestions for fostering innovation are also presented. <<ETX>>
Erlernbarkeit haptischer Fertigkeiten an Simulatoren am Beispiel einer isometrischen Kraftapplikation

Die vorliegende Studie mit 37 Versuchspersonen untersucht die Fahigkeit, eine isometrische Kraftapplikation von 80 Newton durch den einhandigen Zug an einem Simulator so prazise wie moglich zu erlernen und sie zu verschiedenen Zeitpunkten ohne extrinsisches Feedback zu reproduzieren. Die Versuchspersonen wurden dazu in vier verschiedene Feedback-Gruppen aufgeteilt (visuell vs. auditiv, terminal vs. permanent). Die Ergebnisse zeigen eine signifikante Verbesserung uber die drei Testtage in allen Gruppen mit einem signifikanten Vorteil der zwei auditiven gegenuber den visuellen Feedback-Gruppen.
The time-course of sentence meaning composition

Contemporary semantic theories can be classified along two dimensions: (i) the way and time-course in which contextual factors influence sentence truth-conditions; and (ii) whether and to what extent comprehension involves sensory, motor and emotional processes. In order to explore this theoretical space, our ERP study investigates the time-course of the interaction between the lexically specified \(\textit {telic component}\) of a noun (the function of the object to which the noun refers to, e.g., a funnel is generally used to pour liquids into containers) and an \(\textit {ad-hoc affordance}\) contextually induced by the situation described in the discourse. We found that, if preceded by a neutral discourse context, a verb incongruent with the noun’s telic component as in "She uses the funnel to \(\it hang\) her coat" elicited an enhanced N400 compared to a congruent verb as in "She uses the funnel to \(\it pour\) water into a container. " However, if the situation introduced in the preceding discourse induced a new function for the object as an \(\textit {ad-hoc}\) affordance (e.g., the funnel is glued to the wall and the agent wants to hang the coat), we observed a crossing-over regarding the direction of the N400 effect: comparing the \(\textit {ad-hoc}\) affordance-inducing context with the neutral context, the N400 for the incongruent verb was significantly reduced, whereas the N400 for the congruent verb was significantly enhanced. We explain these results as a consequence of the incorporation of the contextually triggered \(\textit {ad-hoc}\) affordance into the meaning of the noun. Combining these results with an analysis of semantic similarity values between test sentences and contexts, we argue that one possibility is that the incorporation of an \(\textit {ad-hoc}\) affordance may be explained on the basis of the mental simulation of concurrent motor information.
Conservation Genetics of the Endangered Yellow Lampmussel (Lampsilis cariosa)

Abstract. Determining the genetic diversity of unionid populations is important for the preservation of the species and ecosystems in which they reside. The Yellow lampmussel, Lampsilis cariosa, is an endangered unionid found along the Atlantic Slope drainages in the United States and Canada. Along with many other North American unionid species, L. cariosa populations are declining. In order to enhance conservation efforts, the genetic structure and diversity of current populations must be examined. A sample of 178 individuals of L. cariosa from 20 populations in the Susquehanna and Delaware River drainages, and two different river populations in Maine were genotyped at the mitochondrial cytochrome oxidase subunit one (COI) gene and seven microsatellite loci. Haplotype genetic diversity for L. cariosa was low, while nucleotide diversity was high. Analysis of mtDNA showed significant population structure but lower than that of other mussel species. Our results indicate past gene flow among populations found in the Susquehanna and Delaware drainages with recent demographic expansion. As an endangered species with currently small population sizes, conservation efforts for L. cariosa should focus on protecting genetic diversity by preserving the largest populations in different drainages.
Identifikasi Sumber Bising Berdasarkan Sinyal Campuran dengan Algoritma Minimum Variance Distortionless Response Weighted (MVDRW) pada Mesin Kompresor

The vibration of the rotating engine can produce mixed sound and noise. The purpose of this study is to localize the noise sources by using mixed signals. The angular spectrum method with the Minimum Variance Distortionless Response Weighted (MVDRW) algorithm was used in this study. The mixed signal recording of a compressor engine with turbine drive was performed in this study. The mixed signal consists of 3 sources that produced from some parts of the compressor engine in the real plant. The experimental set results, at a distance of 60 cm, there are 3 noise sources that located at 44 °, 99 °, and 151 ° of the axis with different spatial positions 1 ° at source 1, 1 ° at source 2, and 1 ° at source 3 of the experimental set. Based on the results, the noise source on the compressor component is at source 2, the opposite side turbine.
Mechanisms for meaningful consent in Internet of Things

Consent is a key measure for privacy protection and needs to be `meaningful' to give people informational power. It is increasingly important that individuals are provided with real choices and are empowered to negotiate for meaningful consent. Meaningful consent is an important area for consideration in IoT systems since privacy is a significant factor impacting on adoption of IoT. Obtaining meaningful consent is becoming increasingly challenging in IoT environments. It is proposed that an “apparency, pragmatic/semantic transparency model” adopted for data management could make consent more meaningful, that is, visible, controllable and understandable. The model has illustrated the why and what issues regarding data management for potential meaningful consent [1]. In this paper, we focus on the `how' issue, i.e. how to implement the model in IoT systems. We discuss apparency by focusing on the interactions and data actions in the IoT system; pragmatic transparency by centring on the privacy risks, threats of data actions; and semantic transparency by focusing on the terms and language used by individuals and the experts. We believe that our discussion would elicit more research on the apparency model' in IoT for meaningful consent.
Polimorfismos del gen Dopamina beta hidroxilasa y su asociación con temperamento bovino

El temperamento en bovinos se define como el comportamiento en respuesta a la manipulacion humana y esta influenciado por el sistema simpatico adrenal. El gen DBH (Dopamina beta hidroxilasa) bovino esta ubicado en el cromosoma 11 y codifica para la Dopamina beta hidroxilasa (DBH), enzima indispensable para la sintesis de este neurotransmisor. Se han identificado polimorfismos de nucleotido simple en el exon 12, posiblemente asociados a cambios en el temperamento en bovinos. El objetivo de este estudio fue encontrar polimorfismos en dicha region y asociarlos con rasgos de temperamento en las razas Blanco orejinegro (BON – Bos taurus taurus ), de lidia ( Bos taurus taurus ) y brahman ( Bos taurus indicus ). Se utilizaron 80 individuos para evaluar comportamiento en brete (CB) y velocidad de salida (VS), y en 52 de ellos se secuencio un fragmento de 702 pb en el exon 12 del gen identificando 22 haplotipos. El menor numero de haplotipos (4), la menor diversidad nucleotidica (0,0012±0,0011) y el mayor numero de loci fijos se presentaron en bovinos de Lidia. Hubo moderada diferenciacion entre las poblaciones con la menor distancia genetica (F ST =0,03309) presente entre las razas Bos taurus . Se presentaron diferencias (p<0,05) en VS, siendo esta menor en machos BON que en Brahman (1,45±0,61 y 2,02±0,74 respectivamente) y en hembras Brahman que en hembras de Lidia (1,05±0,58 y 2,23±0,80 respectivamente). Aunque no se presento asociacion con los polimorfismos geneticos encontrados, se sugiere una posible influencia de fuerzas de seleccion en el exon 12 que podria influir en otras caracteristicas comportamentales. DOI: http://dx.doi. org/10.21615/cesmvz.11. 1.5
Embedding topological spaces into Hausdorff $\omega$-bounded spaces

Let $\kappa$ be an infinite cardinal. A topological space $X$ is $\kappa$-bounded if the closure of any subset of cardinality $\le\kappa$ in $X$ is compact. We discuss the problem of embeddability of topological spaces into Hausdorff (Urysohn, regular) $\kappa$-bounded spaces, and present a canonical construction of such an embedding. Also we construct a (consistent) example of a sequentially compact separable regular space that cannot be embedded into a Hausdorff $\omega$-bounded space.
Designing humour in human computer interaction (HUMIC 2017)

Humor is a social phenomenon pervasive in all human societies. Due to its importance in interpersonal relations, in this workshop we are focusing on the integration of humor in HCI exploring its benefits and downsides, as well as design and evaluation approaches for humorous machines. The workshop will provide a forum for discussions to all researchers and practitioners interested in this topic covering both verbal and non-verbal aspects of humor in HCI.
X-ray Fluorescence Analysis in Weed Science

X-ray fluorescence analysis (XFA) is a new method for the spatial localization and quantification of herbicide residue on leaf surfaces. The distribution pattern of propanil (3′,4′-dichloropropionanilide) on the surface of prune (Prunus domestica L.) leaves sprayed to simulate drift is easily mapped using XFA. Residue distribution maps may be electronically enhanced. Enhancement does not qualitatively change the information content of the map when done with discretion.
Factors for Hospitalization in a Medically Complex Population of Pediatric Home Care Patients

Research has identified demographic, clinical, and technological characteristics that are associated with recurrent pediatric hospital admissions. However, research focusing on risk factors for hospitalization among pediatric home care patients is lacking. The purpose of this study was to identify characteristics associated with 60-day hospitalization among pediatric home care patients. To address this objective, we used information collected from pediatric home care patients, age 6 months to 17 years, who were served by a large not-for-profit home care agency in New York City between 2008 and 2012 (N = 6,187). Results showed that 5.4% of patients in our study population were hospitalized. Specific characteristics that were significantly associated with hospitalization are described in detail.
Acute malnutrition: an everyday emergency. A 10-point plan for tackling acute malnutrition in under-fives.

Despite increased attention to nutrition in recent years acute malnutrition remains a particularly neglected issue with no significant decline seen in the global number of cases in the past two decades. Today we launch ‘Generation Nutrition’ - a new campaign to turn this situation around. For the first time in history we have the knowledge and the means to prevent and treat acute malnutrition. By tackling this issue head-on we can contribute to further reductions in child deaths from preventable causes in the years to come and help to promote human and economic development. The Generation Nutrition campaign brings together a diverse and growing group of civil society organisations calling on governments and the international community to take urgent action to prioritise the fight against acute malnutrition and save the lives of millions of children under the age of five. We believe that with strong political will our goal of a world free of child deaths from acute malnutrition can be achieved within a generation. But we must act now. The Generation Nutrition launch report sets out a 10-point plan for addressing acute malnutrition as part of a broader commitment to tackling undernutrition as a whole.
Local translation of yeast ERG4 mRNA at the endoplasmic reticulum requires the brefeldin A resistance protein Bfr1

Brefeldin A resistance factor 1 (Bfr1p) is a non-essential RNA-binding protein and multi-copy suppressor of brefeldin A sensitivity in Saccharomyces cerevisiae. Deletion of BFR1 leads to multiple defects, including altered cell shape and size, change in ploidy, induction of P-bodies and chromosomal mis-segregation. Bfr1p has been shown to associate with polysomes, binds to several hundred mRNAs, and can target some of them to P-bodies. Although this implies a role of Bfr1p in translational control of mRNAs, its molecular function remains elusive. In the present study, we show that mutations in RNA-binding residues of Bfr1p impede its RNA-dependent co-localization with ER, yet do not mimic the known cellular defects seen upon BFR1 deletion. However, a Bfr1 RNA-binding mutant is impaired in binding to ERG4 mRNA which encodes an enzyme required for the final step of ergosterol biosynthesis. Consistently, bfr1Δ strains show a strong reduction in Erg4p protein levels. Polysome profiling of bfr1Δ or bfr1 mutant strains reveals a strong shift of ERG4 mRNA to polysomes, consistent with a function of Bfr1p in elongation. Collectively, our data reveal that Bfr1 has at least two separable functions: one in RNA-binding and elongation during translation, in particular at the ER membrane, and one in ploidy control or chromosome segregation.
Comparative Analysis of Different Feature Extractionand Classifier Techniques for Speaker IdentificationSystems: A Review

Speech recognition is a natural means of interaction for a human with a smart assistive environment. In order for this interaction to be effective, such a system should attain a high recognition rate even under adverse conditions. In Speech Recognition speech signals are automatically converted into the corresponding sequence of words in text. When the training and testing conditions are not similar, statistical speech recognition algorithms suffer from severe degradation in recognition accuracy. So we depend on intelligent and recognizable sounds for common communications. In this paper, we first give a brief overview of Speech Recognition and then describe some feature extraction and classifier technique. We have compared MFCC, LPC and PLP feature extraction techniques. We efficiently tested the performance of MFCC is more efficient and accurate then LPC and PLP feature extraction technique in voice recognition and thus more suitable for practical applications.
An Interesting Family of Symmetric Polynomials

Abstract We discuss two natural extremal problems for homogeneous polynomials. These problems have simple solutions for polynomials in one or two variables but become interesting for polynomials in three or more variables. We introduce a family of homogeneous symmetric polynomials in three variables that solve one of these problems and have a number of other interesting properties. For example, their coefficients are integers that can be expressed as sums of binomial coefficients and possess a certain divisibility property. Furthermore, these polynomials are connected in a simple way to a family of polynomials arising as sharp examples in the study of proper polynomial mappings between balls in complex Euclidean space.