Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Prenatal Topiramate Administration on Early Postnatal Expression of GFAP in Radial Glial Cells in Albino Rat Cerebellum and Spinal Cord

Background: Topiramate is known as a modern drug approved for the treatment of patients with partial seizures. Radial glial cells are bipolar-shaped cells in the developing central nervous system of vertebrates. It can differentiate into other neurons and astrocytes. GFAP, Glial fibrillary acidic protein, is a glial intermediate filament protein that is known as the most comprehensive marker for astroglial cells including the radial glia Aim of the work: There are few reports on topiramate administration during pregnancy. Therefore, this drug was chosen to investigate its effects, if any, especially the expression of GFAP in radial glia in the pups’ cerebellum and spinal cord. Material and Methods: Male and female rats were coupled in one cage for mating. On the next morning, mating was approved by the presence of sperms in the female vaginal swab, it was considered as Gestation Day zero:0. Twelve female pregnant rats were divided equally into two groups; control and topiramate treated. Topiramate drug was given to the treated group via orogastric tube from GD zero (0) till the time of delivery in a dose of 100mg/kg the control rats were administered tap water by orogastric tube. At the end of the experiment, the newly born pups (PN1) were weighed, anesthetized with Ketamine (60 mg/kg i.p.). The cerebellum and spinal cord were dissected and weighted. The specimens were fixed in Bouin’s solution then processed for preparation of H& E and GFAP immunostained sections. Results:In H& E-stained sections, the cerebellum in the control group was formed of subsequent layers, purkinje cells were arranged in one row, rounded or fusiform shape. GFAP positive Immunostained radial fibers (Bregman glia) were detected in granular and purkinje cell layers. The treated group showed that cells were disorganized and degenerated with focal areas of neuronal loss. Weak GFAP reaction was observed in Bregman glia in granular, purkinje and white matter cell layers. The lumbosacral segment of the spinal cord ventral horn showed large multipolar motor neurons with vesicular nucleus (“owl-eye” appearance), dendrites and axons were obvious. Glial cells with deeply stained nuclei were noticed. In the treated group, neurons appeared degenerated, vacuolated cytoplasm and pyknotic nuclei with focal areas of cellular loss. GFAP immunostained section in the control group showed an intense reaction in the radial fibers of the glia of the ventral funiculus, in contrast to the treated group which showed a faint reaction in both ventral funiculus and horn. Conclusion: it could be concluded that daily regular administration of topiramate during a childbearing period in females may result in a neurotoxic effect in the cerebellum and spinal cord. So, the administration of this drug should be under strict medical observation.
Toolkit for Weighting and Analysis of Nonequivalent Groups: A guide to the twang package

The effect size plot illustrates the effect of weights on the magnitude of differences between groups on each pretreatment covariate. These magnitudes are standardized using the standardized effect size described earlier. In these plots, substantial reductions in effect sizes are observed for most variables (blue lines), with only one variable showing an increase in effect size (red lines), but only a seemingly trivial increase. Closed red circles indicate a statistically signiőcant difference, many of which occur before weighting, none after. In some analyses variables can have very little variance in the treatment group sample or the entire sample and group differences can be very large relative to the standard deviations. In these situations, the user is warned that some effect sizes are too large to plot.
Hydrothermal Synthesis and Electrochemical Performances of Ag-coated Nanoflake-like Li4Ti5O12 as an Anode Material for Lithium-ion Batteries

The inherent low electronic conductivity of Li4Ti5O12 leads to a lower capacity and poor rate performance under high current charge/discharge conditions, which causes serious polarization of the lithium-ion battery. In this work, a Li4Ti5O12 precursor was prepared by a hydrothermal method, and Ag-modified materials with different Ag contents of 0 wt. %, 3 wt. %, 5 wt. %, 7 wt. % and 9 wt. % were prepared by one-step calcination at 600 °C. The characterization of composite materials was performed through XRD, SEM, TEM, and XPS. Electrochemical tests, such as constant current charge and discharge, cycle performance, rate performance, cyclic voltammetry and electrochemical impedance spectroscopy tests, were also conducted to check the electrochemical performances of Ag-modified materials. The results show that the Ag@Li4Ti5O12 composite has better electrochemical performance than pristine Li4Ti5O12. Under a current density of 32 mA∙g , the discharge specific capacity of pristine Li4Ti5O12 reaches 160.35 mAh∙g -1 during the first cycle while the Ag@Li4Ti5O12 composite with 7 wt. % Ag exhibits a higher value of 256.75 mAh∙g. Moreover, its high-rate capacity at 1600 mA∙g is greatly enhanced from 102.91 mAh∙g to 146.56 mAh∙g after Ag modification. It is proven that the addition of an appropriate amount of Ag can increase not only the extraction and insertion of lithium ions but also the diffusion coefficient of lithium ions, which can reduce electrode polarization and improve the conductivity of the material. The conductivity of the Ag@Li4Ti5O12 composite with 7 wt. % Ag is 1.833×10 S∙cm, which is much higher than that of pristine Li4Ti5O12 (6.399×10 -6 S∙cm), making Ag@Li4Ti5O12 a promising high-performance anode material.
Effect of peptide modification on incorporation

The endogenous Staphylococcus aureus sortase A (SrtA) transpeptidase covalently anchors cell wall-anchored (CWA) proteins equipped with a specific recognition motif (LPXTG) into the peptidoglycan layer of the staphylococcal cell wall. Previous in situ experiments have shown that SrtA is also able to incorporate exogenous, fluorescently labelled, synthetic substrates equipped with the LPXTGmotif (K(FITC)LPETG-amide) into the bacterial cell wall, albeit at high concentrations of 500 μM to 1 mM. In the present study, we have evaluated the effect of substrate modification on the incorporation efficiency. This revealed that (i) by elongation of LPETG-amide with a sequence of positively charged amino acids, derived from the C-terminal domain of physiological SrtA substrates, the incorporation efficiency was increased by 20-fold at 10 μM, 100 μM and 250 μM; (ii) Substituting aspartic acid (E) for methionine increased the incorporation of the resulting K(FITC)LPMTG-amide approximately three times at all concentrations tested; (iii) conjugation of the lipid II binding antibiotic vancomycin to K(FITC)LPMTG-amide resulted in the same incorporation levels as K(FITC)LPETG-amide, but much more efficient at an impressive 500-fold lower substrate concentration. These newly developed synthetic substrates can potentially find broad applications in for example the in situ imaging of bacteria; the incorporation of antibody recruiting moieties; the targeted delivery and covalent incorporation of antimicrobial compounds into the bacterial cell wall.
Length-weight relationship, condition factor and relative condition factor of Alosa braschnikowi and A. caspia in the southeast of the Caspian Sea (Goharbaran)

The main objectives of the present study were to determine the species composition of Caspian shad, genus Alosa and to estimate the LWR, CF, and Kn of A. braschnikowi and A. caspia during different months in the southeastern coast of the Caspian Sea. Two fishing methods, small mesh size beach seine and gillnet were used from December 2013 through July 2014. A. braschnikowi and A. caspia, were distinguished in the southeastern part of the Caspian Sea (Goharbaran), consisting of 57.1% and 42.9% of the Alosa catch, respectively. The slopes (b values) of the length-weight regression were 3.241 and 2.844 which were significantly different from 3 (P<0.05), indicating positive and negative allometric growth, respectively. The average CF of A. braschnikowi and A. caspia were calculated as 0.72 ± 0.12 and 0.83 ± 0.13, respectively. The average CF for both species were significantly different among months (P<0.001). There was a significantly negative correlation between size classes and CF of A. caspia. The Kn was greater than 1 for A. braschnikowi and lower than 1 for A. caspia indicating good well-being of A. braschnikowi as opposed to A. caspia in the southeastern Caspian Sea.
INSERTS USED BY ARIANA GRANDE OF INTERVIEW IN JIMMY FALLON TALK SHOW

This research aimed to present the types and the functions of inserts used by Ariana Grande in her interview on Jimmy Fallon talk show and to increase the learners‘ awareness of inserts when they hesitate in the foreign language, which is the very common in speaking. This study implemented a descriptive qualitative research with discourse analysis approach. The subject is a famous singer Ariana Grande. The data were inserts used by the Ariana Grande interview in Jimmy Fallon talk show from the transcript of 6 minutes interview video. The study seeks to answer two research questions: (1) What are the types of inserts in Ariana Grande‘s interview in Jimmy Fallon talk show? And (2) What are the functions of inserts in Ariana Grande‘s interview in Jimmy Fallon talk show? Therefore, answer these problems, the researchers integrate applied types and functions inserts theory from Stenström (1998) and Baleen (2001). The results of this study showed that there were five types of inserts; those were response form, discourse markers, response elicitors, interjections, and greeting. During the interview, the most used insert type by Ariana is response forms which is about 68%, while the less one is interjection inserts, only 5%. Furthermore, this study also showed five functions of inserts, namely response form, discourse markers, response elicitors, interjections, and greeting.
META-HEURISTIC PROCEDURE TO FIND THE SOLUTION OF JOB SHOP SCEDULING PROBLEM

In most production environment, there is a requirement for effective use of the available resources. Job Shop Scheduling Problem (JSSP) because of its key impact on revenues is at the crux of production planning, of late also known as Enterprise Resource Planning (ERP). Industrial tasks ranging from assembling cars to scheduling airplane maintenance crews are easily modeled as instances of JSSP, and improving solutions by even as little as one percent can have a significant financial impact. Efforts have been put to find not necessarily an optimal solution, but a good one to solve these problems. Tabu Search (TS) is an effective local search algorithm for the JSSP, but the quality of the best solution found depends on the initial solution used. The motivation behind such a paper is to layout critical discussion on the Tabu Search technique for JSSP, based on neighborhood structures for finding initial solutions, in order to better serve the needs of manufacturing community trying to apply Tabu Search technique on their problems. In this paper a approach is presented that uses a different methods, that either single scheduling or double scheduling, with functions of neighborhood selection in Tabu Search Method. The approach is tested on a set of standards instances taken from the literature and compared with other approaches. The computation results validate some effectiveness of the proposed algorithm.
Physiologic and Biochemical Changes of Mimetic Aging Induced by D-galactose in Rats

Objective To observe the changes of aging data of Wistar rats in the subacute aging model induced by the subcutaneous injection with D-galactose.Methods 20 male Wistar rats were divided randomly into two groups.Each group contained 10 rats for the control or aging model.The control rats were injected subcutaneously with 10 ml PBS/kg each day,and the rats of the aging model with 48 mg D-galactose/kg each day.After 42 days with continuous injection,the blood specimens were collected for the detection of the data relative to the aging. Results Compared with the control , the weight of the aging model rats increased slowly. The thymus of these rats shrivelled clearly,and their weight decreased as well (P0.01). In addition,the superoxide dismutase(SOD) activity in the serum of these aging rats declined obviously(P0.01). Conclusion The aging model could be established by the mimic aging reaction induced with D-galactose.
HIP-HOP DRAMATICALLY CHANGED THE IDEA OF THE CONSUMER INTO AN ACTIVE PRODUCER OF POPULAR CULTURE

The people of The United States of America have been influenced by the existence of Hip-Hop culture. Initiated by a community movement in the late 1960’s, it plays significant roles in the development of music, television, fashion, and lifestyles. This article examines Hip-Hop phenomenon from the perspective of Popular Culture and Remix Culture by exposing several case studies. The writer provides examples from each aspects of the development throughout the U.S.A. It is found that the phenomenon of Hip-Hop re-shifts the scheme of the consumer into a producer. The four elements: DJ, Rap, Break Dance and Grafitti created a new chain in the continuous production of Popular Culture.
Efficacy of Nutrition Screening Tools in Predicting the Length of Hospital Stay in Older Hospitalized Patients

Objective: The prevalence of malnutrition remains high in older hospitalized patients. Subjective Global Assessment, the Nutrition Risk Screening-2002, and Malnutrition Universal Screening Tool are widely used screening and assessment tools, but comparison of their efficacy in predicting clinical outcomes like length of hospital stay remain scarce. This study aimed to compare the efficacy of these tools in predicting length of hospital stay in a group of older hospitalized patients. Materials and Methods: A retrospective analysis was performed in a sample of 72 patients consecutively admitted to a geriatric medicine ward. Subjective Global Assessment, Nutrition Risk Screening-2002 and Malnutrition Universal Screening Tool were performed within 24 hours of admission. Patients were classified as having prolonged length of hospital stay if they stay in the hospital for more than ten days. The association of baseline malnutrition defined by each tool and the prolonged length of hospital stay was assessed using unadjusted and adjusted logistic regression models. Results: The mean age of the patients was 73.5 ± 6.9 years, and 61.1% were women. The prevalence of malnutrition was 45.8% with Subjective Global Assessment, 51.4% with Nutrition Risk Screening-2002, and 33.3% with Malnutrition Universal Screening Tool. Among the entire cohort, twenty-nine patients (40.2%) had longer length of the hospital stay. After adjusted for covariates, multivariate logistic regression analysis revealed that the Subjective Global Assessment had the best predictive power (OR: 3.9; p: 0.02), followed by Nutrition Risk Screening-2002 (OR: 3.8; p: 0.03), and Malnutrition Universal Screening Tool (OR: 2.9; p: 0.02). Conclusion: Malnutrition assessed by the Subjective Global Assessment, Nutrition Risk Screening-2002 and Malnutrition Universal Screening Tool on admission predict prolonged length of hospital stay in hospitalized older patients.
Effectiveness And Current Recommendation Of Manual Therapy On Hip Osteoarthritis. An Overview

Introduction: Osteoarthritis (OA) is the most common joint disease, increases with age and it is estimated that in those over 60 years of age more than 80 % have OA in at least one joint. Currently, the evidence regarding manual therapy (MT) in hip OA has had unclear results. Therefore, the main objective of this study is to determine the effectiveness and recommendation of MT in the hip OA. And secondary objectives, (I) review the existing literature on the intervention of MT in hip OA, (II) calculate the effectiveness of MT techniques in hip OA and (III) determine if there are benefits after the MT intervention in hip OA. Methods: A systematic search was carried out in electronic databases, in order to compile the available literature between the years 2000 and 2019, taking as reference the PRISMA statement for systematic reviews. Letters to the editor, bibliographic reviews and gray literature were excluded. Results: After reviewing 30 articles, we included 7 RS and 14 RCTs. 7 RCTs measured pain intensity of OA in response to MT vs. a control group. 4 RCTs measuring pain intensity in hip OA using MT + exercises Seven RCTs measured function in subjects with hip OA in response to MT vs. CG. Two RCTs evaluated the effects of MT + Ex on function. Discussion: Although the results were in favor of manual therapy, compared to the control group, these RESUMEN Introducción: La osteoartritis (OA) es la enfermedad articular más frecuente, aumenta con la edad y se estima que en los mayores de 60 años más del 80 % tienen OA en, al menos, una articulación. Actualmente, la evidencia respecto a la terapia manual (TM) en la OA de cadera ha tenido resultados poco claros, por lo que el objetivo principal de este estudio es determinar la efectividad y recomendación de TM en la OA cadera. Los objetivos secundarios son: a) revisar la literatura existente sobre la intervención de TM en OA de cadera; b) calcular la efectividad de las técnicas de TM en OA de cadera, y c) determinar si hay beneficios después de la intervención de TM en OA cadera. Métodos: Se realizó una búsqueda sistemática en bases de datos electrónicas, con el fin de recopilar la literatura disponible entre los años 2000 y 2019, tomando como referencia la declaración PRISMA para revisiones sistemáticas. Se excluyeron las cartas al editor, revisiones bibliográficas y literatura gris. Resultados: Después de revisar 30 artículos, incluimos 7 RS y 14 ECA. 7 ECA midieron la intensidad del dolor de la OA en respuesta a TM vs. un grupo de control. 4 ECA que midieron la intensidad del dolor en la OA de cadera que usaban TM + ejercicios Siete ECA midieron la función en sujetos con OA de cadera en respuesta a TM vs. CG. Dos ECA evaluaron los efectos de TM + Ex en la función. REVISIÓN DOI: 10.20986/resed.2020. 3835/2020
Control of the size and compositional distributions in a milling process by using a reverse breakage matrix approach

A method based on the reverse breakage matrix approach is proposed for controlling the effects that milling has on the particle size distribution and composition of the comminuted material. Applicability, possibilities, and limitations of the proposed method are tested on examples related to the process of wheat flour milling. It has been shown that the reverse matrix approach can be successfully used for defining the particle size distribution of the input material leading to the desired, predetermined particle size and compositional distribution in the output material. Moreover, we have illustrated that it is possible to simultaneously control both, input and output particle size distribution, together with the composition of the output material.
Role of intralesional bleomycin in recurrent or residual keloids and hypertrophic scars

Background: Keloids and hypertrophic scars are difficult to treat. There are many modalities available with variable success rate. Triamcinolone is still the most commonly used drug but recurrence and partial response to this conventional treatment is still a major concern. Many studies have proved the role and efficacy of intralesional bleomycin and this study was done to assess the role of intralesional bleomycin in recurrent and residual lesions. Methods: The patients with recurrent lesion or residual lesions after the injection of triamcinolone were enrolled in the study. Patients received local infiltration of bleomycin. The injections were scheduled at monthly intervals for three consecutive months. They were followed at 1 st , 2 nd , 3 rd , and 12 th months. Scar assessment was done by calculating its volume, Vancouver scar scale (VSS) and visual analogue score (pain and pruritis). Side effects were also recorded. Final assessment was done at 1year for any recurrence. Results: Twenty-five patients completed the study. The most common location of scars was presternal (52%) and trauma was the most common cause in scars (20%). We observed the decrease of volume of 75.85% which was highly significant on statistical analysis (p=0.001). Similarly, statistically significant difference was noticed in VSS, VAS for pain and pruritis. No systemic side effects were noticed. No recurrence was noted at the end of 12 months. Conclusion: Intralesional bleomycin is found to be useful in management of recurrent or residual lesions. It can be a potential option in the management of recurrent and residual hypertrophic scars and keloids.
Odor code sensor and odor reproduction

In biological olfactory systems, odor receptors receive odor molecules by recognizing the molecular information. Humans can sense the odor by the signal from these activated receptors. The combination of the activated receptors is called “odor code,” and the odor codes are expressed as an “odor cluster map” of glomeruli on the olfactory bulb surface. The odor code is essential information for qualitative and quantitative analyses of odor sensation. In this chapter, development of odor sensors based on the odor code concept and an attempt to extract the parameters for odor coding from molecular informatics are described. Application of the obtained odor code for odor reproduction is also presented.
Toxicological Effect of Euphorbia heterophylla Linn

Euphorbia heterophylla has been reported to possess enormous medicinal benefits hence there is a need for holistic research on its toxicological effects. Four different solvents (cold and hot water, chloroform and 80% methanol) were used to extract the aerial parts of Euphorbia heterophylla Linn. Experimental albino rats were obtained from Federal University of Technology Akure’s Microbiology Department Animal House. Toxicological analysis of Euphorbia heterophylla extracts was carried out on the experimental albino rats. The animals were grouped into thirteen with three rats in a group different concentrations of the extracts were administered orally to different groups of the rats for a period of two weeks (14 days). Sterile distilled water was administered to the negative control group. During the 14 days of extracts administration, the animals were observed for clinical manifestations like salivation, nervousness, imitability, itching of the nose and diarrhoea. After the expiration of the two weeks, the animals were sacrificed and vital organs like heart, liver, kidney and intestine were harvested and examined for any degenerative changes and lesions. Blood samples were collected before and after the administration of the extracts to check for blood parameters (Packed Cell Volume (PCV), white blood cell count (total and differential), erythrocyte sedimentation rate (ESR) and haemoglobin (Hb) estimation. The toxicological results of the Original Research Article Kone and Onifade; JOCAMR, 12(3): 1-15, 2020; Article no.JOCAMR. 62949 2 extracts showed various degrees of abnormalities detected in the histopathological sections of the intestine, kidney and the heart. It was found that all the extracts at different concentrations burnt the intestinal walls of all the animals tested. There were significant reductions in the total white blood cells (WBC) and neutrophil counts while there was a significant increase in the lymphocytes count after the administration of the extracts. The findings of this study revealed that Euphorbia heterophylla had toxicological effects on the albino rats organs but increases there lymphocytes count, boosting their immune system, however advance researches to eliminate the toxic phytochemicals from the extract is recommended.