Miracle-dz/UniFAR-FTUs huggingface dataset:
Pharmaceutical Mini-Tablets, its Advantages, Formulation Possibilities and General Evaluation Aspects: A Review

The objective of controlled drug delivery systems is to reduce the frequency of the dosing and to increase the effectiveness of the drug by localization. In oral controlled drug delivery systems, multiple unit dosage forms (MUDFs), like granules, pellets and minitablets effectively control the release of the drug when compared to single unit dosage forms (SUDFs) like tablets and capsules. Among all MUDFs, mini-tablets offer several advantages like they can be manufactured relatively easily, they do not require any solvent for their production, can be coated reproducibly, and also requires less coating material. Also, there is a great flexibility during their formulation development. In this context, last few decades have witnessed some major advancement. This review emphasizes the various advantages of mini-tablets, formulation possibilities, general evaluation tests, and brief insight to marketed drugs.
Instrumented compliant wrist for dexterous robotic interaction

The design, assembly and implementation of a custom fabricated instrumented wrist aimed at supporting dexterous robotic interaction with live proximity and contact feedback is presented in this paper. Although comparable platforms have been conceived in the past, efforts have been made to reduce the complexity of the overall system with a focus on weight and cost reduction and the addition of a proximity detection feature. Design considerations are explored and compared to similar existing compliant wrists. An experimental characterization of the prototype is reported in the context of an integrated vision-guided robotic system. An evaluation of other possible applications, namely for mobile robotics, is also presented.
Forum Jeunes Chercheurs à Inforsid 2014

Le Forum Jeunes Chercheurs a ete organise lors du congres Inforsid 2014 a Lyon. Il a accueilli 17 doctorants de premiere ou deuxieme annee travaillant dans le domaine des systemes d’information. Ils ont redige un article et presente leurs travaux lors d’une session pleniere du congres. Cet article coordonne par Guillaume Cabanac (en qualite d’organisateur du Forum) presente une selection des quatre meilleures contributions au forum.
The impact of social distance on customer rewarded referral program

Rewarded referral programs is a popular way to stimulate word of mouth, its effect depends on not only the economic benefits, but also the social interaction. Based on the social distance theory, in this study analyze the process of the customer rewarded referral program to find how the economic interaction and social interaction interact each other, and how it influences customer referral. In the paper, we use natural field experiment and choose the bank customers as the object. Finally, the result suggested that the social distance moderates the relationship between the recommendation rewards and willingness to recommend. The reward plays a greater role in improving the possibility to recommend in far social distance than close social distance. To reward the referrer will be more effective than to reward the referred customer, when the social distance is far. In contract, when social distance is close, to reward the referred customer will be more effective than to reward the referrer.
Bacterial flagella rotating in bundles: a study in helical geometry.

Bacterial flagella are semi-rigid helices that undergo true rotation. In peritrichously flagellated bacteria (e.g., Escherichia and Salmonella) there are many flagella on each cell; during translational cell movement these operate as a coordinated bundle that actively disperses upon reversal of the rotation sense. The dynamic behavior of a set of helices originating on separate rotational axes is explored by a working model, geometrical analysis, and hydrodynamic calculations. A critical relationship exists between the interaxial separation and phase difference of parallel helices with overlapping domains; in the subcritical case the filaments are not intertwisted, whereas in the supercritical case they are intertwisted in the same sense (left-handed) as the helices, with one twist per helical turn. During counter-clockwise rotation (the sense operative in forward swimming) any preexisting twists of this kind are automatically cancelled and the helices brought progressively into phase. Hydrodynamic calculations suggest that some wrapping then occurs in a right-handed sense, opposite to that of the helices; this necessitates a distortion from true helical geometry which is minimized by maintaining a coaxial in-phase relationship. A highly coordinated helical bundle results that is capable of operating smoothly for an indefinite period, in agreement with the observed behavior of swimming bacteria. During reverse rotation, the supercritical case develops to cause jamming of the bundle, as has been observed with bacteria in high-viscosity medium. The explosive dispersal of the bundle during reversal in low-viscosity medium is a consequence of a complicating phenomenon, namely, a drastic change in flagellar quaternary structure. The overall conclusion is that bundle formation and function are perfectly compatible with a rotational mechanism for the individual flagella.
Drift, growth, and survival of larval Northeast Arctic cod with simple rules of behaviour

Due to vertical variations in ocean circulation, larval Northeast Arctic cod Gadus morhua may influence their own drift routes by migrating vertically. By coupling a larval individual- based model and a general circulation model, we simulated larval vertical positioning according to simple rules based on individual risk sensitivity. This enabled us to investigate how larval growth, survival and horizontal distribution vary between individuals following different rules. Immediate depth selection follows from the rules, with implications for environmental exposure and instanta- neous growth rates. The behavioural rules had long-term and large-scale consequences, since verti- cal positioning influences the drift trajectory of the larva, and thereby the physical environment the larva experiences along its way. Two alternative rule formulations were explored, each containing the full range of strategies, from maximising immediate growth to maximising immediate survival. Fitness was defined as accumulated survival probability up to 18 mm for larvae released at 2 impor- tant spawning grounds in the Lofoten area. Both rules gave better fitness than for individuals drifting at fixed depths. The most successful individuals performed active vertical migration and had an inter- mediate risk sensitivity. When risk sensitivity was allowed to change with ontogeny, larvae that first emphasised growth and then changed to intermediate risk sensitivity were the most successful ones, although improvements were minor compared to fixed sensitivities. The 2 spawning grounds led to slight differences in fitness, but success as a result of risk sensitivity was similar at both, suggesting that optimal larval strategies may be robust across different spawning grounds.
Design of a DSTATCOM using a 5-level cascade asymmetric multilevel converter

The power quality in distribution systems is affected by the pollution introduced by the customers. One way to improve the power quality is using a DSTATCOM to compensate reactive power and harmonics. The use of multilevel inverters in medium voltage applications is a good solution. In particular, the cascaded asymmetric multilevel converter (CAMC) appears as a very attractive alternative among the 5-level converters for this application. In this paper, the design of a DSTATCOM employing a CAMC in a medium voltage distribution power system, is presented. The model and the control strategy are discussed in d-q coordinates. The performance of the proposed compensator is tested with SPICE simulations.
ICSV 14 Cairns • Australia 9-12 July , 2007 GENERATION AND VALIDATION OF ACOUSTIC 3 D WBT MODELS OF A SUV DRIVER COMPARTMENT FROM SEA MODELS

The wave based technique (WBT) constitutes an upcoming simulation technique which results in reduced simulation time and reduced simulation errors compared to finite element (FE) approaches for solving Helmholtz problems. The finite element analysis represents a method which basis functions approximate the boundaries exactly. On the other hand the WBT basis functions are a solution of the Helmholtz equation but its weighted superposition fulfil the boundaries only approximately. However it takes much time to generate a WBT model of a driver compartment of complex vehicle interior geometries because of the requirement that each WBT domain must be a convex volume. Therefore a compromise has to be found between real vehicle surface geometry and its simplifications to coarse box models. A process is introduced which allows the generation of WBT models including the set up of the required boundary conditions based on complete vehicle AutoSEA models. As an example the WBT analysis is applied for a complex SUV driver compartment and validated. The model is used to calculate the over all damping factor of the cavity and the acoustic performance of a head liner is analysed with respect to human in-cabin communications.
Direct evidence of dust growth in L183 from MIR light scattering

Theoretical arguments suggest that dust grains should grow in the dense cold parts of molecular clouds. Evidence of larger grains has so far been gathered in near/mid infrared extinction and millimeter observations. Interpreting the data is, however, aggravated by the complex interplay of density and dust properties (as well as temperature for thermal emission). We present new Spitzer data of L183 in bands that are sensitive and insensitive to PAHs. The visual extinction AV map derived in a former paper was fitted by a series of 3D Gaussian distributions. For different dust models, we calculate the scattered MIR radiation images of structures that agree agree with the AV map and compare them to the Spitzer data. The Spitzer data of L183 show emission in the 3.6 and 4.5 micron bands, while the 5.8 micron band shows slight absorption. The emission layer of stochastically heated particles should coincide with the layer of strongest scattering of optical interstellar radiation, which is seen as an outer surface on I band images different from the emission region seen in the Spitzer images. Moreover, PAH emission is expected to strongly increase from 4.5 to 5.8 micron, which is not seen. Hence, we interpret this emission to be MIR cloudshine. Scattered light modeling when assuming interstellar medium dust grains without growth does not reproduce flux measurable by Spitzer. In contrast, models with grains growing with density yield images with a flux and pattern comparable to the Spitzer images in the bands 3.6, 4.5, and 8.0 micron.
Genome wide expression analysis of the effect of Pinelliae Rhizoma extract on psychological stress

Pinelliae Rhizoma has been used traditionally as an antidepressant in Oriental medicine. In this study, the effect of Pinelliae Rhizoma extract (PRe) on psychological stress was investigated in mice. The results of an elevated plus‐maze experiment revealed that application of psychological stress to mice led to the development of an abnormal behavioral pattern. However, oral administration of PRe significantly reduced the abnormal behavior of mice with a recovery rate of 75.5%. To elucidate the molecular mechanism by PRe, a microarray analysis of the brains of mice was conducted. The results of this analysis revealed that 456 genes were up‐regulated and 392 genes were down‐regulated in response to psychological stress. The expression of most of the genes that were altered in response to psychological stress was restored to normal levels in PRe treated mice, with a recovery rate of 81.5% and 85.2% being observed for up‐ and down‐regulated genes, respectively. Finally, when the interaction network information was analysed, the recovery rate of the core node genes (46 up‐ and 29 down‐regulated genes) in PRe treated mice was found to be over 95%, which indicates that this final set of genes may be the effective target of PRe. Copyright © 2009 John Wiley & Sons, Ltd.
Lateralized Changes in Regional Cerebral Blood Flow during Performance of Verbal and Facial Recognition Tasks: Correlations with Performance and “Effort”

Functional neuroimaging has been used to investigate neural substrates of mnemonic processes, and cerebral blood flow (CBF) measures have been sensitive to activation with memory tasks. Studies of memory with two-dimensional 133Xenon clearance techniques found that word and face recognition tasks produced contralateral CBF changes in mid-temporal cortical regions. This study replicated the activation paradigm, expanding to the three-dimensional resolution of positron emission tomography (PET). Word and face recognition, and a control baseline task were administered to 19 healthy right-handed volunteers (11 men, 8 women) during successive 10 min PET 15O-water measures of CBF. Quantitative CBF rates were calculated with the arterial input function and the equilibrium model. Redistributions of blood flow were compared across tasks-using both absolute and relative (region/ whole brain) CBF. Replicating the 133Xenon clearance findings, CBF was "appropriately" lateralized during task performance (left-right for words > left-right for faces) in the mid-temporal region. Contrary to predictions, the recognition tasks did not activate expected mesolimbic or prefrontal areas. The task-induced CBF changes also correlated with performance. Bilateral CBF in mid-temporal and parahippocampal gyrus regions of interest correlated with the ability to correctly identify word targets (sensitivity). Left-lateralized CBF in the amygdala and hippocampus correlated with better word sensitivity as well as specificity (ability to correctly reject foils). Complementally, right-lateralized CBF in the parahippocampal gyrus correlated with better face specificity performance. In addition, left-lateralized CBF in the amygdala and right-lateralized CBF in the parahippocampal gyrus and hippocampus correlated with "mental effort" indices (task performance relative to basal ability) for word and face memory tasks, respectively. Thus, whereas this recognition task showed the expected lateralized increase in the mid-temporal region and not in frontal and limbic areas, lateralized activation in some of these areas was associated with better performance. Exploratory analyses on other regions showed lateralized changes in one additional temporal region, the occipital-temporal, and several limbic regions.
Intraventricular Angiotensin Elicits Drinking in the Baboon 1

Summary Cannulas aimed at the lateral cerebral ventricles were surgically implanted in baboons. A-II (5 /xg/animal) or control injections were made on subsequent days and water intake recorded to determine the patency of the cannulas. We found that (a) baboons drink considerable water after the IVT administration of A-II, (b) the response diminishes but still persists with repeated A-II tests spread over a several-month interval, and (c) elevated drinking in response to the administration of A-II is a practical way to confirm the success of ventricular cannulation.
Exploratory Visual Analysis for Animal Movement Ecology

Movement ecologists study animals' movement to help understand their behaviours and interactions with each other and the environment. Data from GPS loggers are increasingly important for this. These data need to be processed, segmented and summarised for further visual and statistical analysis, often using predefined parameters. Usually, this process is separate from the subsequent visual and statistical analysis, making it difficult for these results to inform the data processing and to help set appropriate scale and thresholds parameters. This paper explores the use of highly interactive visual analytics techniques to close the gap between processing raw data and exploratory visual analysis. Working closely with animal movement ecologists, we produced requirements to enable data characteristics to be determined, initial research questions to be investigated, and the suitability of data for further analysis to be assessed. We design visual encodings and interactions to meet these requirements and provide software that implements them. We demonstrate these techniques with indicative research questions for a number of bird species, provide software, and discuss wider implications for animal movement ecology.
Influence of subjective visual vertical misperception on balance recovery after stroke

Background: Subjective visual vertical (SVV) perception can be perturbed after stroke, but its effect on balance recovery is not yet known. Aim: To evaluate the influence of SVV perturbations on balance recovery after stroke. Methods: 28 patients (14 with a right hemisphere lesion (RHL) and 14 with a left hemisphere lesion (LHL)) were included, 5 were lost to follow-up. SVV perception was initially tested within 3 months after stroke, then at 6 months, using a luminous line, which the patients adjusted to the vertical position in a dark room. Mean deviation (V) and uncertainty (U), defined as the standard deviation of the SVV, were calculated for eight trials. Balance was initially assessed by the Postural Assessment Scale for Stroke (PASS), and at 6 months by the PASS (PASS6), a force platform (lateral and sagittal stability limits (LSL6 and SSL6)), the Rivermead Mobility Index (RMI6) and gait velocity (v6). Functional outcome was also assessed by the Functional Independence Measure at 6 months (FIM6). Results: The scores for balance and for FIM6 were related to the initial V value: PASS6 (p = 0.01, τ = −0.38); RMI6 (p = 0.002, τ = −0.48), LSL6 (p = 0.06, τ = −0.29), SSL6 (p = 0.004, τ = −0.43), v6 (p = 0.01, τ = −0.36) and FIM6 (p = 0.001, τ = −0.49), as well as to the initial U value: PASS6 (p = 0.03, τ = −0.32), RMI6 (p = 0.02, τ = −0.35), SSL6 (p = 0.005, τ = −0.43) and FIM6 (p = 0.01, τ = −0.38). Conclusions: Initial misperception of verticality was related to a poor score for balance after stroke. This relationship seems to be independent of motricity and neglect. Rehabilitation programmes should take into account verticality misperceptions, which could be an important factors influencing balance recovery after stroke.
Industrialisation et secteur informel dans les pays en développement

Nous presentons un modele theorique a deux periodes et trois secteurs tentant d'expliquer, par la structure de l'economie, la divergence que l'on retrouve entre la taille du secteur informel dans les pays developpes et celle observee dans les pays en developpement. Le modele developpe fait le lien entre deux modeles d'industrialisation et de formalisation dans le but de montrer comment l'industrialisation peut avoir un effet sur la taille du secteur informel. Ensuite, nous presentons trois modifications de ce modele. Nous montrons aussi le role joue par les autres parametres du modele et enfin nous presentons differentes politiques publiques ayant pour but de faire diminuer la taille du secteur informel. ______________________________________________________________________________
The interpretation of the component structure of event-related brain potentials: an analysis of expert judgments.

The analysis of components of the event-related brain potential (ERP) is accomplished through standardized statistical algorithms. However, visual inspection of ERPs is commonly used to guide the selection of the analytic techniques. Thus, the definitional criteria of components employed by the investigators may interact with the choice of analysis procedures. The present study examines the criteria which investigators employ to define components of the ERP, the relative importance assigned to different criteria, and the consistency with which investigators use the definitional criteria. ERPs are simulated so as to vary systematically the amplitude, latency, duration, and electrode distribution of the P300 component. Ten experienced ERP researchers rated the similarity of 153 pairs of simulated ERPs. The ratings were analyzed by a multidimensional scaling procedure. Eight unidimensional judgments on each of the 18 ERPs were also obtained. The results suggest that ERP investigators are capable of accurately recovering the underlying dimensions of a set of simulated ERPs. Furthermore, the degree of experience in analyzing and interpreting ERPs affects the weighting structure of the underlying dimensions. These findings support the commonly held, but previously untested, belief that judgments of ERPs based on visual inspection can be both accurate and reliable
Effects of the germfree state on the response of mice exposed to neutron-gamma radiation.

The response of germfree and conventional mice has been compared after exposure to a wide dose range of fission spectrum neutrons (300 rads to 50 000 rads). Acute radiation effects as measured by percentage survival and by survival time were different: mice free of detectable bacteria were more "resistant" to neutron radiation than were conventional controls. Germfree mice had a higher threshold for the production of mortality, had a greater proportion of 30-day survivors and had longer survival times after all of the radiation exposures. The median lethal dose (LD 50/30) for conventional mice was 328 rads; for germfree it was 414 rads, or 1.3 times higher. The relative resistance associated with the germfree state in mice exposed to neutrons is of the same magnitude as that already established for germfree mice exposed to x-rays. After exposure to supralethal amounts of neutrons extending well into the range producing evidence of severe damage to the central nervous system, the median survival times of g.
Incorporating the prosthetic: Traumatic, limb-loss, rehabilitation and refigured military bodies

In this article, I look at the role that context of injury plays in the rehabilitation of military patients who sustained a limb amputation as a result of blast injury trauma in Afghanistan and Iraq. This article contrasts the technologically driven model of rehabilitation produced by the US Armed Forces Amputee Patient Care Program at Walter Reed Army Medical Center with a person centered approach building on work in medical anthropology. In this article, two case studies are contrasted illustrating the reasons behind the rejection of an upper extremity prosthetic device in one example and the acceptance of one in another. I argue that even in light of the incredible advances in medical technique and prosthetic technology, a body and functionality focussed rehabilitation must also pay attention to the subjective experiences of individual patients in terms of their present and their past.
Bähler Statistical analysis of saturating transposon mutagenesis in fission yeast

In this project a transposon mutagenesis library in fission yeast, assembled in the Bahler-Lab at UCL, is investigated using a 3 state and 4 state Hidden Markov Model. An initially assembled Hidden Markov Model was adjusted to allow for the classification of regions within the yeast genome. Classifications group regions by their essentiality to a cells fitness and growth, based on transposon density within that region. This allows for a genome wide classification and the ability to find essential non-coding RNAs as laid out in the result section. Also a very interesting large region, classified as essential by the HMM, has been identified within chromosome III with almost no prior annotation from the PomBase data base. A region, one of many, which has been identified by the HMM as essential to growth and fitness of a cell but very little a prior annotation.