Miracle-dz/UniFAR-FTUs huggingface dataset:
Self‐Report and Observer Measures of Substance Abuse Among Homeless Mentally Ill Persons in the Cross‐Section and Over Time

The comparability of self-report and observer measures of substance abuse among 118 homeless mentally ill persons was assessed using cross-sectional and longitudinal measures. Possible correlates of nondisclosure were identified from demographic variables and clinical indicators. Lifetime abuse reported at baseline was a sensitive predictor of subsequent abuse behavior in the project, but cross-sectional measures based only on self-report or observer ratings failed to identify many abusers. A total of 17% of the subjects never disclosed abuse that was observed during the project. The level of substance abuse is likely to be severely underestimated among homeless mentally ill persons when only one self-report measure is used at just one point in time. This problem can, however, largely be overcome by incorporating information from observers and from multiple follow-ups or by focusing on lifetime rather than current abuse. We also conclude that underreporting may bias estimates of some correlates of substance abuse.
L'accord sur la conservation des albatros et des pétrels : la protection de la biodiversité marine face à l'industrie de la pêche

L'Accord sur la conservation des albatros et des petrels signe a Canberra en 2001 vise a proteger ces grands migrateurs aujourd'hui tres menaces, essentiellement par leur capture incidente lors d'operations de peche en mer. Pour etre efficace, ce nouvel instrument de preservation de la biodiversite va devoir s'imposer, face a l'industrie de la peche et dans le contexte juridique propre du droit qui la regit.
Clinical Indicators for Endotracheal Suctioning in Adult Patients Receiving Mechanical Ventilation.

BACKGROUND Critically ill patients who need mechanical ventilation require endotracheal suctioning. Guidelines recommend coarse crackles over the trachea and/or the presence of a sawtooth pattern on the flow-volume loop of the ventilator waveform as the best indicators. OBJECTIVE To determine clinical cues for endotracheal suctioning in patients who require mechanical ventilation. METHODS A descriptive study of 42 adult patients receiving mechanical ventilation. After baseline endotracheal suctioning with a closed-system device, patients were assessed hourly up to 4 hours for guideline-based cues for endotracheal suctioning and lung sounds were auscultated. Endotracheal suctioning was done when cues were detected or 4 hours after baseline suctioning. Secretions were collected, measured, and weighed. RESULTS Most patients were male (62%) and white (93%). Mean age was 51 years, and mean duration of mechanical ventilation was 7.5 days. The median time to endotracheal suctioning was 2 hours, and a mean of 4.4 mL of secretions was removed. Three patients had no cues identified but had 1.0 mL or more of secretions. The most frequent cues were crackles over the trachea (88%), sawtooth waveform (33%), coughing (29%), and visible secretions (5%). Cues resolved and physiological parameters improved after suctioning. Coarse lung sounds did not improve. CONCLUSIONS Patients receiving mechanical ventilation should be routinely assessed for coarse crackles over the trachea, the most common indicator for endotracheal suctioning. Despite common practice, assessment of lung sounds to identify the need for suctioning is not supported.
A parity checker for a large residue numbers based on Montgomery reduction method

Fast and simple algorithm of a parity checker for a large residue numbers is presented. A new set of RNS moduli with 2/sup r/- (2/sup l//spl plusmn/ 1) form for fast modular multiplication is proposed. The proposed RNS moduli has a large dynamic range for a large RNS number. The parity of a residue number can be checked by the Chinese remainder theorem (CRT). A CRT-based parity checker is simply organized by the Montgomery reduction method (MRM), implemented by using multipliers and the carry-save adder array. We present a fast parity checker with minimal hardware processed in three clock cycles for 32-bit RNS modulus set.
Development of bronchus associated lymphoid tissue (BALT) in human lung disease: a normal host defence mechanism awaiting therapeutic exploitation?

The lung is continuously subjected to a barrage of agents carried in the air we breathe, many of which are antigenic and hence capable of eliciting potentially tissue damaging immunoinflammatory reaction in the lung and airways. To deal with these challenges we have developed a series of overlapping defence mechanisms with increasing levels of complexity. Mucociliary clearance and alveolar macrophage ingestion represent front line "exclusion" mechanisms in the respiratory tract, and these are bolstered by immune surveillance involving lymphocytes and local accessory cells responsible for trapping inhaled antigens for presentation to the immune system. This "adaptive" immunity confers a higher level of specificity onto local defences, the clearest example being the role of secretory IgA antibodies in increasing the efficiency of antigen exclusion at the epithelial surface. In addition, the adaptive immunity makes available a broader range of effector mechanisms (such as cell mediated cytotoxicity) which are specialised for dealing with incoming antigens that successfully broach front line exclusion barriers. However, the same immune defence mechanisms have the potential for damaging host tissues and the increased appearance of activated lymphocytes in some respiratory diseases, such as asthma and sarcoidosis, have prompted suggestions that they may play a direct part in the pathogenesis of these diseases. The distribution of lymphocytes in the normal and diseased lung has been the subject of intense investigation
Pennyroyal oil poisoning and hepatotoxicity.

PENNYROYAL oil has been used in folklore medicine for many years as an abortifacient and as a means to induce menstruation.1Herbal medicine books currently in health food stores mention its use as an abortifacient and recommend its use for various minor ailments. We report two recent cases of pennyroyal oil ingestion for the purpose of abortion. One of these cases resulted in shock, disseminated intravascular coagulation (DIC), massive hepatic nercrosis, and death. Report of Cases Case 1. — An 18-year-old girl came to the Denver General Hospital emergency department on Nov 15,1978, with abdominal pain, nausea, vomiting, and vascilating between lethargy and agitation. She gave a history of having ingested two one-half ounce bottles of pennyroyal oil two hours earlier to abort a suspected pregnancy. She was very depressed, and the ingestion could also have been a suicide attempt. She had drunk pennyroyal tea made from the leaves of
How Accumulated Real Life Stress Experience and Cognitive Speed Interact on Decision-Making Processes

Rationale: Advances in neurocomputational modeling suggest that valuation systems for goal-directed (deliberative) on one side, and habitual (automatic) decision-making on the other side may rely on distinct computational strategies for reinforcement learning, namely model-free vs. model-based learning. As a key theoretical difference, the model-based system strongly demands cognitive functions to plan actions prospectively based on an internal cognitive model of the environment, whereas valuation in the model-free system relies on rather simple learning rules from operant conditioning to retrospectively associate actions with their outcomes and is thus cognitively less demanding. Acute stress reactivity is known to impair model-based but not model-free choice behavior, with higher working memory capacity protecting the model-based system from acute stress. However, it is not clear which impact accumulated real life stress has on model-free and model-based decision systems and how this influence interacts with cognitive abilities. Methods: We used a sequential decision-making task distinguishing relative contributions of both learning strategies to choice behavior, the Social Readjustment Rating Scale questionnaire to assess accumulated real life stress, and the Digit Symbol Substitution Test to test cognitive speed in 95 healthy subjects. Results: Individuals reporting high stress exposure who had low cognitive speed showed reduced model-based but increased model-free behavioral control. In contrast, subjects exposed to accumulated real life stress with high cognitive speed displayed increased model-based performance but reduced model-free control. Conclusion: These findings suggest that accumulated real life stress exposure can enhance reliance on cognitive speed for model-based computations, which may ultimately protect the model-based system from the detrimental influences of accumulated real life stress. The combination of accumulated real life stress exposure and slower information processing capacities, however, might favor model-free strategies. Thus, the valence and preference of either system strongly depends on stressful experiences and individual cognitive capacities.
Health State Utilities for Childhood Attention-Deficit/Hyperactivity Disorder Based on Parent Preferences in the United Kingdom

Objectives. The purpose of this study was to use standard gamble (SG) utility interviews to assess parent preferences for health states of childhood attention-deficit/hyperactivity disorder (ADHD). Methods. The study was conducted in August 2003 in London, England. Parents (N = 83) of children diagnosed with ADHD completed SG utility interviews, rating their child’s current health and 14 hypothetical health states describing untreated ADHD and ADHD treated with a nonstimulant, immediate-release stimulant, or extended-release stimulant. Raw temporary utilities ranging from 0 (worst health) to 1 (best health) were adjusted to a chronic utility scale ranging from 0 (death) to 1 (best health) using a linear transformation. Parents rated the severity of their children’s ADHD symptoms using the Attention-Deficit/Hyperactivity Disorder Rating Scale-IV (ADHD-RS) and their children’s health-related quality of life using the EuroQol EQ-5D. Results. Raw and adjusted SG ratings of hypothetical health states ranged from 0.63-0.90 and 0.88-0.96, respectively. Parents’ raw SG scores of their child’s current health state (mean = 0.72) were significantly correlated with inattentive, hyperactive, and overall ADHD symptoms (r = -0.25, -0.27, -0.27; P < 0.05) and the EQ-5D visual analogue scale (r = 0.26; P < 0.05). Conclusion. This UK-based study suggests that parent SG interviews are a valid method for obtaining utilities for child ADHD-related health states. The utilities obtained in this study would be appropriate for use in a cost-utility analysis evaluating the costs and benefits of childhood ADHD treatments in the United Kingdom.
Dissociation between Categorical and Coordinate Spatial Computations: Modulation by Cerebral Hemispheres, Task Properties, Mode of Response, and Age

Kosslyn suggested a dissociation of two kinds of spatial representations: categorical and coordinate, the former computed by the left hemisphere and the latter by the right hemisphere. In addition, with practice, a "categorization" of the coordinate computation would appear. These suggestions resulted largely from an experiment, replicated by others, in which the subjects had to estimate the relative position of a dot and a line by giving an oral response, and feedback was provided. The present series of five experiments was an attempt to test whether this finding could be generalized, under several methodological manipulations, some of which have already been used by researchers in separate studies. In the five experiments, accuracy was a more contributive dependent variable than correct latencies, and practice effects on the task X field interaction were not verified. Experiments 1-3 concerned the kind of response. When a manual instead of an oral response was required (Experiment 1; n = 32 Ss), the expected dissociation was observed (as well as when the latency of responses made by the right hand were studied). When the number of oral responses was increased from two (a binary choice) to eight, the dissociation was still observed for accuracy but disappeared when a more liberal criterion of accuracy was used to reduce the considerable task effect (Experiment 2; n = 32 Ss), or when response requirements were equated for both tasks (Experiment 3; n = 32 Ss). In Experiment 4 (n = 32 Ss), a manual response was called but the feedback was removed and the task dissociation disappeared. Finally, the task dissociation observed in Experiment 1 was not verified when a sample of elderly subjects was enrolled (Experiment 5; n = 32 Ss). However, age per se was the source of an interesting additional dissociation since only the coordinate computation was age sensitive. Our results suggest that the dissociation proposed by Kosslyn between the computation of categorical vs coordinate spatial relationships is highly unstable and sensitive to subtle methodological factors (vocal vs manual response, presence vs absence of feedback, binary vs "continuous" response, age) which could preclude its general application.
Assessing the effects of a sequestered germline on interdomain lateral gene transfer in Metazoa

A sequestered germline in Metazoa has been argued to be an obstacle to lateral gene transfer (LGT), though few studies have specifically assessed this claim. Here, we test the hypothesis that the origin of a sequestered germline reduced LGT events in Bilateria (i.e., triploblast lineages) as compared to early‐diverging Metazoa (i.e., Ctenophora, Cnidaria, Porifera, and Placozoa). We analyze single‐gene phylogenies generated with over 900 species sampled from among Bacteria, Archaea, and Eukaryota to identify well‐supported interdomain LGTs. We focus on ancient interdomain LGT (i.e., those between prokaryotes and multiple lineages of Metazoa) as systematic errors in single‐gene tree reconstruction create uncertainties for interpreting eukaryote‐to‐eukaryote transfer. The breadth of the sampled Metazoa enables us to estimate the timing of LGTs, and to examine the pattern before versus after the evolution of a sequestered germline. We identified 58 LGTs found only in Metazoa and prokaryotes (i.e., bacteria and/or archaea), and seven genes transferred from prokaryotes into Metazoa plus one other eukaryotic clade. Our analyses indicate that more interdomain transfers occurred before the development of a sequestered germline, consistent with the hypothesis that this feature is an obstacle to LGT.
JAK/Stat signaling regulates heart precursor diversification in Drosophila

Intercellular signal transduction pathways regulate the NK-2 family of transcription factors in a conserved gene regulatory network that directs cardiogenesis in both flies and mammals. The Drosophila NK-2 protein Tinman (Tin) was recently shown to regulate Stat92E, the Janus kinase (JAK) and Signal transducer and activator of transcription (Stat) pathway effector, in the developing mesoderm. To understand whether the JAK/Stat pathway also regulates cardiogenesis, we performed a systematic characterization of JAK/Stat signaling during mesoderm development. Drosophila embryos with mutations in the JAK/Stat ligand upd or in Stat92E have non-functional hearts with luminal defects and inappropriate cell aggregations. Using strong Stat92E loss-of-function alleles, we show that the JAK/Stat pathway regulates tin expression prior to heart precursor cell diversification. tin expression can be subdivided into four phases and, in Stat92E mutant embryos, the broad phase 2 expression pattern in the dorsal mesoderm does not restrict to the constrained phase 3 pattern. These embryos also have an expanded pericardial cell domain. We show the E(spl)-C gene HLHm5 is expressed in a pattern complementary to tin during phase 3 and that this expression is JAK/Stat dependent. In addition, E(spl)-C mutant embryos phenocopy the cardiac defects of Stat92E embryos. Mechanistically, JAK/Stat signals activate E(spl)-C genes to restrict Tin expression and the subsequent expression of the T-box transcription factor H15 to direct heart precursor diversification. This study is the first to characterize a role for the JAK/Stat pathway during cardiogenesis and identifies an autoregulatory circuit in which tin limits its own expression domain.
The Effect of Zoledronic Acid on the Clinical Resolution of Charcot Neuroarthropathy

OBJECTIVE To investigate the clinical efficacy of zoledronic acid in patients with diabetes and acute Charcot neuroarthropathy. RESEARCH DESIGN AND METHODS Thirty-nine consecutive patients were randomly assigned to placebo or three intravenous infusions of 4 mg zoledronic acid. The primary outcome was clinical resolution of acute Charcot neuroarthropathy determined by total immobilization time (casting plus orthosis). RESULTS At baseline, there was no significant difference between the randomly assigned groups with respect to Charcot disease activity or other baseline values. In the zoledronic acid group, the median time for total immobilization was 27 weeks (range 10–62), and in the placebo group it was 20 weeks (20–52) (P = 0.02). CONCLUSIONS Zoledronic acid had no beneficial effect on the clinical resolution of acute Charcot neuroarthropathy in terms of total immobilization time. It is possible that it may prolong the time to clinical resolution of Charcot neuroarthropathy.
Seasonal variation in the effect of climate on the biology of Rhipicephalus sanguineus in southern Europe

SUMMARY Objective.Rhipicephalus sanguineus is the most widespread tick in the world and a vector of many pathogens infecting dogs and humans. To date, there have been no investigations on the biology of R. sanguineus under natural Mediterranean climatic conditions. Methods. The biology of R. sanguineus was studied under laboratory and natural climatic conditions in southern Italy. Several biological parameters were compared in different seasons, and their correlation with climatic data was assessed. Results. The life cycle of R. sanguineus lasted for a mean of 101·4 and 116·2 days under laboratory and environmental conditions respectively. Reproductive parameters of wild-collected females kept in the environment in May were significantly different from first-generation females maintained in September–October, and the correlation between reproductive parameters and climate data varied according to season. Conclusion. These results indicate that the Mediterranean climate affects the biology of R. sanguineus, which compensates its losses during the initial phases of its cycle in spring with high feeding and moulting rates of larvae and nymphs during summer as well as with high egg production during autumn. These results advance our knowledge of the biology of R. sanguineus and will be useful for the understanding of the eco-epidemiology of tick-borne diseases that this tick transmits.
Versican/PG‐M G3 domain promotes tumor growth and angiogenesis

Versican/PG‐M is an extracellular matrix proteoglycan, expression of which is elevated in a variety of human tumors. The significance of this change is unclear. Here we show that versican G3‐containing fragments are present at high levels in human astrocytoma. Expression of a versican G3 construct in U87 astrocytoma cells enhances colony growth in soft agarose gel and tumor growth and blood vessel formation in nude mice. The G3‐containing medium enhances endothelial cell adhesion, proliferation, and migration. G3‐expressing cells and tumors formed by these cells express increased levels of fibronectin and vascular endothelial growth factor (VEGF). Furthermore, the G3 domain directly binds to fibronectin and forms a complex together with VEGF. In the presence of these three molecules, endothelial cell adhesion, proliferation, and migration were found to be significantly enhanced. Removal of the complex containing these molecules reverses these processes. Taken together, these findings implicate G3 as a modifier of tumor growth and angiogenesis and suggest a new avenue for development of anticancer and anti‐angiogenic therapies based on targeting versican G3 fragments.
Sport und Niere

Arztlich konsequent uberwachte nierenkranke Patienten einschlieslich Nierentransplantierter konnen nicht nur Sport treiben, sie sollten es sogar zur Erhaltung und Verbesserung ihrer korperlichen Belastbarkeit tun. Dies ist in vielen Fallen jedoch nur unter E in schrankungen moglich. Uber die Auswirkungen sportlicher Belastung auf die Nierenfunktion Gesunder und Nierenkranker wird hier berichtet. Daruber hinaus beschaftigt sich die Arbeit mit dem Einflus von Erythropoetin und Diuretika auf die Leistungsfahigkeit von Athleten,
Emergency Department Adult Asthma Care Pathway: Healthcare Providers' Perceived Utility and Barriers to Implementation

Clinical pathways provide an outline for evidence-based care and can reduce variation of care across many healthcare settings including the emergency department (ED). The purpose of this study was to examine healthcare providers' perceptions of an ED Asthma Care Pathway (EDACP) and identify barriers to implementation. Following a 6-month pilot implementation of the EDACP, healthcare providers (physicians, nurses, respiratory therapists, and administrators) at 5 Ontario EDs were surveyed about the content, format, and usefulness of the pathway, as well as barriers to implementation. A focus group was convened to further explore these factors. In total, 207 of 338 mailed surveys were returned. Approximately 60% of respondents felt that the pathway was a useful tool, which enabled adherence with asthma guidelines (81%), decreased variation in patient care (79%), decreased uncertainty in patient management (73%), and increased their knowledge of best practice (87%). Time constraints and length of the pathway were common barriers. Healthcare providers perceive the EDACP to be a useful knowledge translation and guideline implementation tool, which promotes best practices. Although barriers to adoption of the tool have been identified, these may guide content revisions and inform the process for a successful provincial implementation strategy.
Unsupervised Web-based Automatic Annotation

The success of the Semantic Web depends both on the definition of ontologies used to represent the knowledge as on the annotations performed of the web contents. As manual approaches have low scalability, there is a need of tools capable to generate all this knowledge in an automatic and reliable way. In this paper is presented a complete algorithm to annotate web contents in an automatic and unsupervised manner. It is structured in a three-stepped procedure, based on the usage of several concept similarity measures and linguistic patterns. It is able to detect the entities to annotate, the candidate classes of these entities and, finally, associate them with the classes of an ontology. Some prospective results are presented.