Miracle-dz/UniFAR-FTUs huggingface dataset:
Value of Duke Treadmill Score in Setting Priority of Patients for Coronary Angiography

Background: exercise treadmill test remains a good test in identification of coronary artery disease(CAD). The Duke Treadmill Score (DTS), shown to predict CAD better than ST segment deviation alone. Aim of the work: To determine the potential of DTS in setting priority of patients for coronary angiography. Patients and methods: This was a prospective study that was done from July 2017 to October 2018 and included 150 patients referred to Damannhour Teaching Hospital for evaluation of chest pain. Patients underwent: history, clinical examination, ECGs, Echocardiography, Treadmill exercise ECG with calculation of DTS then coronary angiography that was correlated with DTS and other variables. Results: There were 59 patients(39.3%)with high DTS and 91patients (60.7%) with intermediate DTS. For the intermediate Duke's risk group the result of coronary angiography distributed on normal (26.4%), single vessel disease (33%), two vessel disease (22%), and three vessels disease or left main disease (18.7%). For high Duke's risk group the result of coronary angiography showed mainly three vessels disease or left main disease (54.2%), two vessels disease (27.1%), single vessel disease (6.8%) and normal vessel (11.9%), The P value was<0.001. Adding patient's risk factors to intermediate DTS group were statistically significant in the diagnosis of CAD ,the P value was<0.001. Conclusion: The DTS is a good predictor for CAD. Intermediate risk DTS group exercise test results should be managed individually according to clinical data.
WASP-36b: A NEW TRANSITING PLANET AROUND A METAL-POOR G-DWARF, AND AN INVESTIGATION INTO ANALYSES BASED ON A SINGLE TRANSIT LIGHT CURVE

We report the discovery, from WASP and CORALIE, of a transiting exoplanet in a 1.54 day orbit. The host star, WASP-36, is a magnitude V = 12.7, metal-poor G2 dwarf ( K), with [Fe/H] =−0.26 ± 0.10. We determine the planet to have mass and radius, respectively, 2.30 ± 0.07 and 1.28 ± 0.03 times that of Jupiter. We have eight partial or complete transit light curves, from four different observatories, which allow us to investigate the potential effects on the fitted system parameters of using only a single light curve. We find that the solutions obtained by analyzing each of these light curves independently are consistent with our global fit to all the data, despite the apparent presence of correlated noise in at least two of the light curves.
Formulating an improved in vitro hepatic model for drug development and toxicity testing

1. Poster: ‘Chlorpromazine disrupts structural integrity of hepatic cell membranes in human HepaRG cells and initiates a pro-inflammatory response’ K. Morgan1, N. Martucci, A. Kozlowska, W. Gamal, F. Brzeszczynki, K. Samuel, P. Treskes, P. Hayes, L. Nelson, P. Bagnininchi, J. Brzeszczynska and J. Plevris BASL Conference, York, UK Sept 2018 2. Talk and Poster: ‘Chlorpromazine disrupts structural integrity of hepatic cell membranes in human HepaRG cells and initiates a proinflammatory response’ K. Morgan1, N. Martucci, A. Kozlowska, W. Gamal, F. Brzeszczynki, K. Samuel, P. Treskes, P. Hayes, L. Nelson, P. Bagnininchi, J. Brzeszczynska and J. Plevris IBCA Conference, Edinburgh, UK June 2018 3. Poster: ‘TOWARDS UNDERSTANDING THE MECHANISMS OF CHLORPROMAZINEINDUCED HEPATIC TOXICITY USING A HUMAN HEPARGBASED MODEL’ J. Brzeszczynska, K. Morgan1, F. Brzeszczynski, K. Samuel, P. Hayes, J. Plevris EASL Conference, Paris, France 2018 4. Talk/Abstract number 0282 ‘Directed-nanopatterning promotes earlier liver-specific maturation and outperforms metabolic function of differentiated human hepatic HepaRG progenitor cells on standard tissue culture plastic’ Katie Morgan, Anna Bryans, Filip Brzeszczynski, Paul Reynolds, Michael Mabbott, Nicole Martucci, Graham Anderson, Steve Morley, John Plevris, Peter Hayes, Nikolaj Gadegaard, Leonard J Nelson eCells and Materials ISSN 2522-2350282 eCells and Materials, TERMIS EU Conference Davos, Switzerland 2017 5. Talk/Abstract number 0290 ‘Nanotopographical features influence derivation and selection of reference genes for progenitor cell differentiation protocols’ xvi Katie Morgan, Filip Brzeszczynski, Joanna Brzeszczynski, Michael Mabbott, Paul Reynolds, Graham Anderson, Steve Morley, John Plevris, Peter Hayes, Nikolaj Gadegaard, Leonard J Nelson ISSN 25222350290 eCells and Materials, TERMIS EU Conference Davos, Switzerland 2017 6. Poster: ‘Mechanistic Insight into Chlorpromazine-induced Hepatic Tight Junction Disruption Using a Human HepaRG-based Liverbiochip Impedance, A Kozlowska, W. Gamal, K. Morgan, P. Treskes, P. C. Hayes, J. N. Plevris, P. O. Bagnaninchi, L. J. Nelson, 2015, UEG Week, October 24-28, 2015, Barcelona – Spain. Papers 1. Morgan, K. , Martucci, N. , Kozlowska, A. , Gamal, W. , Brzeszczynki, F. , Treskes, P., Samuel, K. , Hayes, P., Nelson, LJ. , Bagnaninchi, P., Brzeszczynska, J., and Plevris, J. (2019) Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line. Biomedicine & Pharmacotherapy, Vol 111, pages 1408-1416 2. Nelson, L. *, Morgan, K. *, Treskes, P., Samuel, K. , Henderson, C. , LeBled, C. , . Plevris, J. (2017). Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications. Basic & Clinical Pharmacology & Toxicology,120 (1), 3037. *equal first author
LMI approach for exponential stabilization of continuous-time delayed Takagi-Sugeno systems

Abstract This paper deals with the analysis and design of controllers for a class of continuous-time delayed Takagi-Sugeno fuzzy systems. Sufficient conditions for the exponential stability are derived based on a fuzzy Lyapunov function. These conditions are expressed in the form of linear matrix inequalities, that depend on the maximum bound of the time delay and the desired decay rate of the system. A Non parallel distributed compensation controller is considered. The controller design problem is presented as an optimization under linear matrix inequalities constraints. This fuzzy controller provides a maximum domain of constraints determined by the time derivative of the membership functions, while guaranteeing the desired decay rate.The effectiveness of the proposed approaches is shown through a numerical example.
Optimising publicity : towards a theoretical model

Generating a continuous presence in the media and targeting mass audiences with predetermined marketing communication messages in the process does not have to be synonymous with large budget allocations and the advertising dimension of integrated marketing communication (IMC) only. Publicity can establish such a media presence with mass audiences without any cost to the organisation. However, this technique of IMC is often neglected and underutilised. A literature review as a non-empirical and qualitative research design was undertaken to develop a theoretical model that can assist marketing communication practitioners in optimising the use of publicity in the marketing communication mix. Die optimale benutting van publisiteit : aanloop tot 'n teoretiese model Die ontwikkeling van 'n deurlopende mediateenwoordigheid en die teikening van massagehore in die proses met voorafbepaalde bemarkingskommunikasieboodskappe hoef nie noodwendig sinoniem te wees met ruim begrotingstoekennings en die uitsluitlike gebruik van reklame as geintegreerde bemarkingskommunikasietegniek nie. Publisiteit kan so 'n mediateenwoordigheid by massagehore skep sonder dat dit die organisasie 'n sent uit die sak hoef te jaag. Desnieteenstaande word hierdie geintegreerde bemarkingskommunikasietegniek dikwels verwaarloos en onderbenut. 'n Literatuurstudie as nie-empiriese en kwalitatiewe navorsingsontwerp word onderneem om 'n teoretiese model te ontwikkel wat bemarkingskommunikasiepraktisyns van hulp kan wees om die gebruik van publisiteit binne die bemarkingskommunikasiemengsel te optimaliseer.
Investigating the Use of Mobile Health Interventions in Vulnerable Populations for Cardiovascular Disease Management: Scoping Review

Background Cardiovascular disease (CVD) has grown to become one of the leading causes of mortality worldwide. The advancements of CVD-related treatments have led to a decline in CVD prevalence among individuals in high-income countries (HICs). However, these improvements do not reflect the state of individuals in low- and middle-income countries (LMICs) and vulnerable subgroup populations in HICs, such as the Indigenous. To help minimize the health disparities in these populations, technology-based interventions have been offered as a potential solution, but there is concern regarding if they will be effective, or even needed, as these tools have been designed for use in HICs. Objective The objective of this study was to explore how mobile health (mHealth) interventions currently assist individuals in Indigenous communities and LMICs with CVD management. Methods A scoping review guided by the methods outlined by Arksey and O’Malley was conducted. A comprehensive search was completed by 2 reviewers in 5 electronic databases using keywords related to mobile health, cardiovascular disease, self-care, Indigenous communities, and LMICs. Studies were screened over 2 rounds and critically reviewed using a descriptive-analytical narrative method. Descriptive data were categorized into thematic groups reflecting the major findings related to the study objective. Results We identified a total of 11 original articles and 11 review papers that met the criteria for this scoping review. The majority of the studies included a telemonitoring- and text messaging (short message service, SMS)–related feature associated with the intervention. The use of SMS was the most common approach to effectively promote disease management among individuals in both LMICs and Indigenous communities. However, customizing for cultural considerations within the design of the intervention was highlighted as a pivotal component to encourage CVD management. Specifically, individuals emphasized that the inclusion of collaborative partnerships with community members would strengthen the effectiveness of the intervention by ensuring it was designed with the appropriate context. Conclusions Technology-based interventions used within Indigenous communities and LMICs have shown their potential to assist individuals with managing their condition. Although the literature available regarding this topic is limited, this review outlines key components to promote the effective use of these tools in the context of these vulnerable populations.
Measurements of Nanoscale TiO_2 and Al_2O_3 in Industrial Workplace Environments-Methodology and Results

The possible release of engineered nanomaterials was investigated based on a previously developed but now refined methodology. Data from altogether eight industrial work areas in production plants of nanostructured TiO_2 and Al_2O_3 particles were obtained and used to test the methodology and to derive a first assessment of possible exposure of workers. Particle size distributions were determined in work area environments with concurrent measurements at a comparison site. Data from the comparison site were used to estimate the particle background level in the work area and distinguish it from potentially released nanomaterial. The analysis is based on the comparison of time resolved data from the work area and the comparison site as well as data determined during periods with and without work activities in the work area. The data analysis method introduced delivers size-resolved information on the potential nanoparticle exposure of workers. A significant release of particles in the size range 100-562 nm was observed in the work area of bagging aluminum oxide and is stemming from damaging or overfilling of bags, and the necessary activities during the cleaning of the work area. The maximum particle diameter of these particles was around 340 nm. At all other investigated locations no significant releases of particles in the size range 100-562 nm were determined. Also, no significant release of particles ＜ 100 nm was observed in all work areas. The average PM_10 exposure during the work activities varied from 48 to 1,330 μg/m^3 in the different work areas. The maximum concentrations of aluminum were 118 μg/m^3 and 58 μg/m^3 for PM_(10) and PM_1, respectively, during the bagging of Al_2O_3 in small bags. In comparison, the maximum concentrations of titanium were 550 μg/m^3 and 434 μg/m^3 for PM_(10) and PM_1, respectively, during the bagging of TiO_2 and indicate a significant release of coarser particles.
Continuous parametric feedback cooling of a single atom in an optical cavity

C.S. acknowledges financial support from the Bavarian Ph.D. program of excellence QCCC, P.A. A. from the Alexander von Humboldt Foundation and the European Union through the Marie Curie Initial Training Network CCQED (Project No. 264666), and C.H. from the Deutsche Forschungsgemeinschaft via the excellence cluster Nanosystems Initiative Munich.
Tracking Consumer Attention At The Point-Of-Sale

Each new product introduction is accompanied with uncertainty regarding the most appropriate parameters for its design and display, and the optimal amount of shelf space to allocate. An improper location or an under-allocation of space might make a product fail before it achieves full sales potential. For the retailer, optimizing shelf space is also of utmost importance: allocating too many facings is a waste, while allocating too few will result in lost sales due to unmet demand.
Bioactivity screening of various extracts and polysaccharide of local mushroom amauroderma sp. from Royal Belum State Park

Kajian ini bertujuan untuk melakukan penyaringan pelbagai aktiviti biologi menggunakan ekstrak akues rebusan air, ekstrak metanol larut air, ekstrak etanol, ekstrak metanol dan polisakarida miselium cendawan Amauroderma sp. yang diperoleh dari Taman Negeri Royal Belum. Ujian antikanser, antivirus, antibakteria dan antioksida digunakan dalam penyaringan ini. Ujian antikanser dijalankan ke atas sel kanser ovari (CaOV-3) dan sel normal hati Chang dengan tamoxifen digunakan sebagai kawalan. Kesemua nilai IC50 yang diperoleh menunjukkan nilai yang tinggi (400±3.6 - 3950±0.005 μg/mL). Sementara itu, kajian awal penyaringan aktiviti antivirus dimulakan dengan ujian sitotoksisiti ekstrak terhadap sel Vero. Didapati hanya ekstrak rebusan air dan etanol memberi nilai CC50 masing-masing pada kepekatan 6.4±0.3 dan 7.9±1.28 mg/mL. Seterusnya, ujian antivirus menggunakan virus Herpes Simpleks Jenis 1 (HSV-1) yang menjangkiti sel Vero dilakukan dengan dua kaedah iaitu pra-rawat dan pos-rawat. Ekstrak menunjukkan aktiviti yang tidak ketara terhadap HSV-1 bagi kedua-dua kaedah ini. Penyaringan aktiviti antibakteria dilakukan ke atas beberapa jenis bakteria gram negatif dan positif dengan satu siri kepekatan ekstrak; 10, 5, 2.5, 1.25 dan 0.625 mg/mL. Kesemua ekstrak tidak menunjukkan aktiviti antibakteria berdasarkan ketiadaan sebarang zon perencatan dalam kesemua piring petri. Walau bagaimanapun, penyaringan antioksida menunjukkan kadar peratusan penyingkiran radikal bebas yang tinggi terutamanya ekstrak etanol iaitu 93.6%. Ini diikuti oleh ekstrak rebusan air (92.65%), metanol (88.83%) serta polisakarida (85.75%). Memandangkan kesemua ekstrak tidak menunjukkan kehadiran aktiviti sitotoksik, antivirus dan antibakteria, tetapi mempunyai aktiviti antioksida yang signifikan, maka bolehlah disimpulkan bahawa pelbagai ekstrak Amauroderma sp. sangat berpotensi secara khusus sebagai komponen nutrisi bersifat antioksidatif.
Effectiveness of Cough Assist Device in Exercise Capacity in COPD Patients

Coughing is the body’s defense mechanism to clear the airways from the foreign bodies and secretions. In patients with neuromuscular disorders or other diseases affecting the airways such as cystic fibrosis (CF), the effectiveness of this defense mechanism is often reduced due to respiratory exhaustion. Some COPD patients have also difficulty in airway clearance. The aim of this study was to evaluate the effectiveness of cough assist device in COPD patients. In this study, we randomized 20 COPD patients admitted to the pulmonary ward of Masih Daneshvari hospital (Tehran, Iran) into two groups of routine physiotherapy (including active cycle of breathing technique, pursed-lips breathing, diaphragmatic/abdominal breathing, huffing, and coughing) and routine physiotherapy plus 10 sessions of cough assist, each for 20 minutes. Cough assist pressure was set +5 to +30 cmH2O for inspiration and -8 to -33 for expiration, for 1-3 and 3-5 seconds, respectively. The two groups were then compared regarding the results of 6-minute walk test (distance) and spirometry parameters. The mean age of the patients was 61 ± 4 years. The results of the analysis demonstrated that there was a significant difference between the two groups. Keywords: cough assist; respiratory physiotherapy; COPD
Childhood Obesity: Issues of the Burden, its Genesis and Prevention

A variety of mechanisms participate in weight regulation and the development of obesity in children, including genetics, developmental influences ("metabolic programming", or epigenetics), and environmental factors. The relative importance of each of these mechanisms is the subject of ongoing research and probably varies considerably between individuals and populations. Obesity has a cascade negative health, with grave social and economic consequences. Obesity in children and young adolescents is increasing world-wide, including India, in parallel with economic development. Childhood obesity is a now acknowledged as a growing epidemic which demands a preventive management. It is difficult to assess obesity in the young due to a lack of consensus as to how to measure it, especially severe obesity. The standardized prevalence is difficult to compare amongst different countries due to differences in study design. In the last decade several theories on genesis of childhood obesity have emerged. It is established that the young obese are at increased risk of cardiovascular events in addition to other diseases, and a higher risk of all cause mortality during adulthood. The management is multi-disciplinary and complex, but preventive strategies should be the priority. In all cases efforts to incorporate individualized family counselling is preferred. There is a need to increase the awareness among governments, health care professionals and the community that childhood obesity is a major health
An Exploration of Emergent Contributors Within IBM Collaborative Lifecycle Management Ecosystem By

Supervisory Committee Dr. Daniela Damian, (Department of Computer Science) Co-Supervisor Dr. Eric Knauss, (Department of Computer Science and Engineering, CHALMERS) Co-Supervisor Today, software ecosystems have become transparent, allowing users to submit issue reports and new feature requests to the development team. The more permeable boundaries of ecosystems provide an open culture paradigm where stakeholders, customers, developers and other user groups have the access to participate during all phases of requirement development. One example of this open culture in software ecosystems is found in work item discussions, which are aimed to improve how requirements are elicited, analyzed and validated. In this thesis, we investigate who participates in requirements discussions, identifying and focusing on emergent contributors; discussants that are not officially part of the development team or required to participate, but contribute to work item discussions. We report from a case study of online requirement discussion in IBM’s collaborative lifecycle management. We find that external contributors emerge frequently during discussions and that they mediate the clarification of requirements. Our results indicate that it is important for emergent contributors to be involved early in the requirements process, otherwise there is a negative effect on the work items’ progress. We discuss the implications of our findings for both practitioners and researchers with suggestions for future studies.
Biogeographic pattern of four endemic Pyropia from the east coast of Korea, including a new species, Pyropia retorta (Bangiaceae, Rhodophyta)

Copyright © 2018 The Korean Society of Phycology 55 http://e-algae.org pISSN: 1226-2617 eISSN: 2093-0860 Biogeographic pattern of four endemic Pyropia from the east coast of Korea, including a new species, Pyropia retorta (Bangiaceae, Rhodophyta) Sun-Mi Kim, Han-Gu Choi, Mi-Sook Hwang and Hyung-Seop Kim* Division of Polar Life Sciences, Korea Polar Research Institute, Incheon 21990, Korea Aquatic Plant Variety Center, National Institute of Fisheries Science, Mokpo 58746, Korea Department of Biology, Gangneung-Wonju National University, Gangneung 25457, Korea
Wavelet denoising of partial discharge signals and their pattern classification using artificial neural networks and support vector machines

This paper presents two pattern recognition approaches using Partial Discharges fingerprints as input features to classify PD patterns. A multi-layer perceptron (MLP) backpropagation neural network and a support vector machine (SVM) were trained to recognize three types of PD patterns. Experimental results showed that the algorithms can achieve high recognition rates. Moreover, the Discrete wavelet transform (DWT) was used to denoise PD signals as a prior stage to the classification process. Different mother wavelets were tested for different levels of decomposition in order to find appropriate wavelet parameters for better signal to noise ratio (SNR) and less distortion after the denoising process.
An update on diagnosis of tuberculosis: A review

Tuberculosis (TB) is an infectious and contagious disease caused by various strains of Mycobacterium worldwide. In an estimate, 2 billion persons or approximately one third of the world’s population are infected with contagious tuberculus bacillus among which 95 percent of cases occur in people of developing countries. However, it is estimated that only 10–12% of infections result in overt disease. The data gathered by World Organization of Animal Health stated that among 179 countries of world, more than half were reported with the presence of zoonotic TB in livestock and/or wildlife, demonstrating its wide geographical spread. In India bovine tuberculosis was found to be 14.31 per cent to 34.42 per cent. Researchers have proved that most of the active TB infections are curable with early diagnosis followed by appropriate treatment. The available conventional diagnostic techniques are useful but they neither rapid nor cost effective for early accurate and affordable diagnosis, represents a cornerstone to eradicate TB worldwide by 2030. However, current ongoing researches have confirm that TB detection via targeting disease biomarker and the development of new and cheaper tools for biomolecular recognition may circumvent the current limitations of diagnostic methods used in the global fight against TB.
Structure, Conduct and Performance of Tomato

Abstract Marketing of agricultural products especially tomato has been a vocation for most women in Ghana, but little attention has been given to the marketing efficiency of tomato. The study analysed the efficiency of marketing system of tomatoes in Pwalugu in the Upper East Region of Ghana. Th collected through a semi-structured interview with sixty chain. Deconstructed Marketing Margins, Gini Coefficient, Returns on Capital Employed and the marketing efficiency criterion were used in assessing the efficiency of the marketing system of tomatoes. An average profit margin of Gh₵21,888.68, Gh₵110,060.70 and Gh₵1,169.03 for farmers, wholesalers and retailers per year respectively was realized. Also, farmers real wholesalers and 66.0% for retailers. Our finding of a highly profitable tomato marketing industry in Pwalugu is contradictory to the views portrayed in the Ghanaian media. We advocate for a module t tomato marketing and processing under the National Youth Employment Programme (NYEP).