Miracle-dz/UniFAR-FTUs huggingface dataset:
Nuclear ultrastructures associated with the RNA synthesis and processing

Relatively a little is known about the spatial organization of RNA synthesis, processing, and transport in (mammalian) cell nuclei. This review summarizes results of electron microscopic mapping of RNA synthetic sites and macromolecules involved directly, or indirectly, in the metabolism of RNAs in somatic cell mammalian nuclei. Significance of these results will be discussed in the context of the molecular mechanisms underlying spatial arrangements of RNA metabolism. © 1995 Wiley‐Liss, Inc.
Results From Sweden's 2016 Report Card on Physical Activity for Children and Youth.

BACKGROUND The 2016 Swedish Report Card on Physical Activity (PA) for Children and Youth is a unique compilation of the existing physical and health related data in Sweden. The aim of this article is to summarize the procedure and results from the report card. METHODS Nationally representative surveys and individual studies published between 2005-2015 were included. Eleven PA and health indicators were graded using the Active Healthy Kids Canada grading system. Grades were assigned based on the percentage of children/youth meeting a defined benchmark (A: 81% to 100%, B: 61% to 80%, C: 41% to 60%, D: 21% to 40%, F: 0% to 20%, or incomplete (INC). RESULTS The assigned grades were Overall Physical Activity, D; Organized Sport Participation, B+; Active Play, INC; Active Transportation, C+; Sedentary Behaviors, C; Family and Peers, INC; School, C+; Community and the Built Environment, B; Government Strategies and Investments, B; Diet, C-; and Obesity, D. CONCLUSIONS The included data provides some support that overall PA is too low and sedentary behavior is too high for almost all age groups in Sweden, even with the many national policies as well as an environment that is favorable to the promotion of PA.
IMS at EmoInt-2017: Emotion Intensity Prediction with Affective Norms, Automatically Extended Resources and Deep Learning

Our submission to the WASSA-2017 shared task on the prediction of emotion intensity in tweets is a supervised learning method with extended lexicons of affective norms. We combine three main information sources in a random forrest regressor, namely (1), manually created resources, (2) automatically extended lexicons, and (3) the output of a neural network (CNN-LSTM) for sentence regression. All three feature sets perform similarly well in isolation (≈ .67 macro average Pearson correlation). The combination achieves . 72 on the official test set (ranked 2nd out of 22 participants). Our analysis reveals that performance is increased by providing cross-emotional intensity predictions. The automatic extension of lexicon features benefit from domain specific embeddings. Complementary ratings for affective norms increase the impact of lexicon features. Our resources (ratings for 1.6 million twitter specific words) and our implementation is publicly available at http://www.ims. uni-stuttgart.de/data/ims_emoint.
Regenerative medicine for the treatment of Teno-desmic injuries of the equine. A series of 150 horses treated with platelet-derived growth factors.

BACKGROUND/AIM The aim of the present study was to evaluate the safety and the clinical outcome of platelet-rich plasma for the treatment of teno-desmic injures in competition horses. PATIENTS AND METHODS From January 2009 to December 2011, 150 sport horses suffering from teno-desmic injuries were treated with no-gelled platelet-concentrate. RESULTS No horse showed any major adverse reaction as a result of the procedure. Full healing was obtained for 81% of the horses. Twelve percent had clinical improvement and only 7% a failure. Eight percent of cases of relapse were observed. No statistically significant correlation existed between clinical outcome and the area of the lesion. A statistically significant correlation existed between the clinical outcome and the age of the horse. CONCLUSION Treatment with platelet-derived growth factors leads to the formation of a tendon with normal morphology and functionality, which translate in the resumption of the agonistic activity for the horses we treated.
Attitudes to HIV voluntary counselling and testing among mineworkers in South Africa: Will availability of antiretroviral therapy encourage testing?

We conducted a study to identify attitudes that influence uptake of HIV voluntary counselling and testing (VCT) amongst gold mineworkers in South Africa; 105 healthy men were interviewed. The level of basic knowledge of HIV was high, but reported awareness of the extent of HIV infection in the workforce and perceived personal risk of HIV infection was low. Health issues were considered the most important indication for HIV testing and one-third had been tested. Fear of testing positive for HIV and the potential consequences, particularly stigmatization, disease and death, were the major identified barriers to VCT. Half of the participants felt workplace education programmes needed to be improved to promote VCT access. Twenty-six per cent became more favourably inclined towards HIV testing in response to information on improvements that have been made to the confidentiality and convenience of the company's VCT service. Only 14% then indicated that they would be more likely to access VCT if antiretroviral therapy became available. A vigorous community education programme is essential if the introduction of ART is to be effective in promoting uptake of VCT.
Expert-based probabilistic modeling of workflows in context of surgical interventions

To provide assistance functions in context of surgical interventions, the use of medical workflows plays an important role. Workflow models can be used to assess the progress of an on-going surgery, enabling tailored (i.e., context sensitive) support for the medical practitioner. Subsequently, this provides opportunities to prevent malpractices, to enhance the patient's outcome and to preserve a high level of satisfaction. In this work, we propose a framework which enables a formalization of medical workflows. It is driven by a dialog of medical as well as technical experts and is based on the Unified Modeling Language (UML). An easy comprehensible UML activity serves as a starting point for the automatic generation of more complex models that can be used for the actual estimation of the progress of a surgical intervention. In this work, we present translation rules, which allow to transfer a given UML activity into a Dynamic Bayesian Network (DBN). The methods are presented for the application example of a cholecystectomy (surgical removal of the gallbladder).
Topical herbal therapies for treating osteo‐arthritis

The original Cochrane Review was published in 2000 (1), and the separation of its updating into orally and topically used herbal medicines partly reflects the fact that some topical herbal medicines have a skin irritating effect that contributes to their mechanism of action, or they are toxic when used orally. We found seven studies for this review (2), investigating seven herbal medicines: Arnica montana, Capsicum species, Symphytum officinale (that is, comfrey), Urtica dioica (stinging nettle), and three polyherbal mixtures. These are two Chinese herbal mixtures: Fufang Nanxing Zhitong Gao (FNZG) and Shangshi Jietong Gao (SJG), and Marhame-Mafasel. This research evidence suggests that there might be some benefits for some of these treatments, but further studies are needed to confirm the effects beyond doubt. We have found that the proprietary gels from Arnica, and comfrey, and adhesive patches containing the Chinese herbal mixtures may alleviate osteoarthritic complaints, based on single studies with a confirmatory study design. The head-tohead comparisons of the two Chinese herbal mixtures don’t show a preference for one over the other. Considering the other treatments, the 0.0125% capsaicin preparation used in the one included study of this treatment is a lower dose than commonly used in clinical practice, and the results did not show clinically relevant improvement. While, the low quality of the studies of nettle leaf and the polyherbal compress Marhame-Mafasel mean that they are inadequate to allow judgement of the clinical effectiveness of these products. Serious side effects were not reported with any intervention, but skin irritations were common, particularly with stinging nettle leaf and Capsicum extract gel. In summary, when considering topical herbal medicines for osteoarthritis, there is a need to increase the body of evidence on their effects through new, high quality clinical studies, and to conduct further research to identify their active constituents and to better understand their mechanisms of action.
Influence of growth temperature and lipopolysaccharide on hemolytic activity of Serratia marcescens

Log-phase cells of Serratia marcescens cultured at 30 degrees C were approximately 10-fold more hemolytic than those grown at 37 degrees C. By using a cloned gene fusion of the promoter-proximal part of the hemolysin gene (shlA) to the Escherichia coli alkaline phosphatase gene (phoA), hemolysin gene expression as a function of alkaline phosphatase activity was measured at 30 and 37 degrees C. No difference in alkaline phosphatase activity was observed as a function of growth temperature, although more hemolysin was detectable immunologically in whole-cell extracts of cells grown at 30 degrees C. The influence of temperature was, however, growth phase dependent, because the hemolytic activities of cells cultured to early log phase at 30 and 37 degrees C were comparable. Given the outer membrane location of the hemolysin, lipopolysaccharide (LPS) was examined as a candidate for mediating the temperature effect on hemolytic activity. Silver staining of LPS in polyacrylamide gels revealed a shift towards shorter O-antigen molecules at 37 degrees C relative to 30 degrees C. Moreover, there was less binding of O-antigen-specific bacteriophage to S. marcescens with increasing growth temperature, a finding consistent with temperature-mediated changes in LPS structure. Smooth strains of S. marcescens were 20- to 30-fold more hemolytic than rough derivatives, a result confirming that changes in LPS structure can influence hemolytic activity. The alkaline phosphatase activity of rough strains harboring the shlA-phoA fusion was threefold lower than that of smooth strains harboring the fusion plasmids, a result consistent with a decrease in hemolysin gene expression in rough strains. The absence of a similar effect of temperature on gene expression may be related to less-marked changes in LPS structure as a function of temperature compared with a smooth-to-rough mutational change.
Component cost models for multi-objective optimizations of switched-mode power converters

Besides product differentiation, cost is a key parameter for market success and sustainable competitive advantage of industrial companies. Academic research in the field of power electronics, however, is often confined to the search for technical innovations or optimizations with focus on pure physical performance indices while the cost dimension is neglected. An explanation for the lack of such cost considerations is the generally poor availability of cost data in academia. This paper discusses the necessity of an increased awareness and sensitivity towards costs and the related opportunities for academic research. Furthermore, cost models for the power semiconductors, the passive components, the cooling systems and the printed circuit boards of switched-mode power converters with an approximate rated power between 5 and 50kW are derived. Based on manufacturer prices for large ordering quantities, numerical values for the cost model parameters are proposed. An example of a multi-objective comparison of different power converter topologies for photovoltaic applications regarding efficiency, volume and total semiconductor chip area is extended by the cost dimension to demonstrate the benefits of employing the developed cost models.
Importance of post-translational modifications on the function of key haemostatic proteins

Post-translational modifications (PTMs) such as glycosylation and phosphorylation play an important role on the function of haemostatic proteins and are critical in the setting of disease. Such secondary level changes to haemostatic proteins have wide ranging effects on their ability to interact with other proteins. This review aimed to summarize the knowledge of the common PTMs associated with haemostatic proteins and the implications of such modifications on protein function. Haemostatic proteins that represent the main focus for studies specific to PTMs are von Willebrand factor, tissue factor, factor VIII, antithrombin and fibrinogen. These proteins are susceptible to PTMs by glycosylation, phosphorylation, sulphation, citrullination and nitration, respectively, with a significant impact on their function. During synthesis, vWF must undergo extensive PTMs, with N-linked glycosylation being the most common. Increased phosphorylation of tissue factor results in increased affinity for platelets to the vessel endothelium. Citrullination of antithrombin leads to an increased anticoagulant function of this protein and therefore an anticoagulant state that inhibits clot formation. On the contrary, nitration of fibrinogen has been shown to result in a prothrombotic state, whilst sulphation is required for the normal function of Factor VIII. From this review, it is evident that PTMs of haemostatic proteins as a change in protein structure at a secondary level greatly influences the behaviour of the protein at a tertiary level.
A Safety Study of Extract Combination of Legundi ( Vitex trifolia L . ) Leaves and Temulawak ( Curcuma xanthorrhiza R . ) Rhizome as Anti-allergy in Healthy Volunteers .

Objective: The effect of extract combination of legundi (Vitex trifolia L) leaves and temulawak (Curcuma xanthorrhiza Roxb) rhizomes was investigated preclinically as anti allergy. Methods: This formula have been proven relatively nontoxic. Based on these preliminary studies, this formula was then studied in phase I clinical trials to determine the safety and tolerability of the extract in healthy volunteers.The trial was designed as randomized and double blind study with 30 healthy volunteers divided into 3 groups. Each participants in group 1, 2, and 3 received extract combination of legundi leaves and temulawak rhizomes with the dose of 1500 mg/day, 4500 mg/day, and 9000 mg/day, respectively. Drugs will be administered orally three times daily for 14 days. The primary outcome measured were the absence of tolerability and side effects. The secondary outcome measured were value changes in renal, liver function and physical examination before and after drug administration (pre and post control group design). Results: The results showed that the extract combination at the dose of 1500 mg/day and 4500 mg/day were well tolerated and safe, as seen from the absence of the druginduced changes in the renal and liver function. However, there were significant changes in the value of AST and serum creatinine after administration of the extract combination with the dose of 9000 mg/day (p <0.05). There were no significant side effects in the Group 1 and 2, while the thrush and decrease of blood pressure were reported with administration of the doses of 9000 mg/day. Thus, extract combination of legundi leaves and temulawak rhizomes at the dose of 1500 mg/day and 4500 m /day were found to be well tolerated and safe.
Mucosal Immunity: Its Role in Defense and Allergy

The interface between the organism and the outside world, which is the site of exchange of nutrients, export of products and waste components, must be selectively permeable and at the same time, it must constitute a barrier equipped with local defense mechanisms against environmental threats (e.g. invading pathogens). The boundaries with the environment (mucosal and skin surfaces) are therefore covered with special epithelial layers which support this barrier function. The immune system, associated with mucosal surfaces covering the largest area of the body (200–300 m2), evolved mechanisms discriminating between harmless antigens and commensal microorganisms and dangerous pathogens. The innate mucosal immune system, represented by epithelial and other mucosal cells and their products, is able to recognize the conserved pathogenic patterns on microbes by pattern recognition receptors such as Toll-like receptors, CD14 and others. As documented in experimental gnotobiotic models, highly protective colonization of mucosal surfaces by commensals has an important stimulatory effect on postnatal development of immune responses, metabolic processes (e.g. nutrition) and other host activities; these local and systemic immune responses are later replaced by inhibition, i.e. by induction of mucosal (oral) tolerance. Characteristic features of mucosal immunity distinguishing it from systemic immunity are: strongly developed mechanisms of innate defense, the existence of characteristic populations of unique types of lymphocytes, colonization of the mucosal and exocrine glands by cells originating from the mucosal organized tissues (‘common mucosal system’) and preferential induction of inhibition of the responses to nondangerous antigens (mucosal tolerance). Many chronic diseases, including allergy, may occur as a result of genetically based or environmentally induced changes in mechanisms regulating mucosal immunity and tolerance; this leads to impaired mucosal barrier function, disturbed exclusion and increased penetration of microbial, food or airborne antigens into the circulation and consequently to exaggerated and generalized immune responses to mucosally occurring antigens, allergens, superantigens and mitogens.
LA DIVERSIDAD DE GÉNERO EN EL DIRECTORIO Y SU RELACIÓN CON EL DESEMPEÑO FINANCIERO DE LA EMPRESA

En los ultimos anos, las mujeres han progresado en la fuerza laboral. Desde 1970 la proporcion de mujeres en el mercado laboral se ha elevado de 48% a 64%. Sin embargo, mientras hombres y mujeres graduados son reclutados en la misma proporcion por las empresas, la proporcion de mujeres en altos cargos gerenciales es aun muy baja. El objetivo del trabajo es mostrar, para el caso peruano, si existe alguna influencia de la diversidad de genero del directorio en el desempeno financiero de la empresa. Se trabajo con un panel de datos balanceado que se construyo teniendo como fuente principal la Superintendencia del Mercado de Valores del Peru, abarcando los ultimos 10 anos para un conjunto de 137 empresas. El modelo planteado es estatico; de acuerdo a la naturaleza de los datos, estructura del modelo y al test de Hausman, la estimacion debe realizarse por efectos fijos. Por otro lado, con el fin de controlar la causalidad inversa se realiza una estimacion utilizando la tecnica de variable instrumental. Los resultados obtenidos muestran que no existe un efecto significativo de la presencia de una o mas mujeres en el directorio de una empresa sobre el desempeno financiero de esta, esto nos permite indicar que la mujer tiene un desempeno tan eficiente como el del hombre en el directorio. 1 Segun el Grant Thornton International Business Report 2012. El International Business Report de Grant Thornton (IBR) es un sondeo trimestral a 3,000 altos directivos de empresas cotizadas en la bolsa y empresas privadas de todo el mundo. Se inicio en 1992 en nueve paises europeos, en la actualidad el sondeo encuesta a 12,000 empresas lideres en 40 economias en forma anual, aportando elementos para comprender los temas economicos y comerciales que afectan a las companias a nivel global. Los datos de este informe son recopilados de 6,000 entrevistas hechas a lideres de negocios entre noviembre de 2011 y febrero de 2012.
2D‐D Lifting for Shape Reconstruction

We present an algorithm for shape reconstruction from incomplete 3D scans by fusing together two acquisition modes: 2D photographs and 3D scans. The two modes exhibit complementary characteristics: scans have depth information, but are often sparse and incomplete; photographs, on the other hand, are dense and have high resolution, but lack important depth information. In this work we fuse the two modes, taking advantage of their complementary information, to enhance 3D shape reconstruction from an incomplete scan with a 2D photograph. We compute geometrical and topological shape properties in 2D photographs and use them to reconstruct a shape from an incomplete 3D scan in a principled manner. Our key observation is that shape properties such as boundaries, smooth patches and local connectivity, can be inferred with high confidence from 2D photographs. Thus, we register the 3D scan with the 2D photograph and use scanned points as 3D depth cues for lifting 2D shape structures into 3D. Our contribution is an algorithm which significantly regularizes and enhances the problem of 3D reconstruction from partial scans by lifting 2D shape structures into 3D. We evaluate our algorithm on various shapes which are loosely scanned and photographed from different views, and compare them with state‐of‐the‐art reconstruction methods.
GOUVERNEMENT D'ENTREPRISE ET INVESTISSEMENT EN R&D : UNE ETUDE SUR LE SBF 250

L'objectif de cette recherche est d'analyser l'impact des caracteristiques liees a la structure de propriete et au conseil d'administration, en tant que mecanismes de gouvernance, sur l'intensite d'investissement en recherche et developpement (R&D). L'etude menee sur un echantillon de 111 entreprises francaises appartenant a l'indice SBF 250 montre que la concentration de propriete et la dualite des roles de directeur general et de president de conseil n'ont pas d'effet significatif sur l'intensite d'investissement en R&D. La taille du conseil d'administration ainsi que la proportion des administrateurs internes presents dans le conseil ont un effet positif et significatif sur l'intensite d'investissement en R&D. Cependant, la participation des administrateurs au capital a pour effet d'inciter les dirigeants a diminuer le niveau des investissements en R&D.
Phytochemical and Antibacterial Properties of Leaf Extract of Stereospermum kunthianum (Bignoniaceae)

Phytochemical screening and studies on antibacterial activity of leave extract of Stereospermum kunthianum -a plant widely used by traditional medical practitioners in Northern Nigeria, were carried out on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella spp, Salmonella spp and Aeromonas hydrophila using agar well diffusion technique. Preliminary phytochemical screening revealed the presence of sterols, coumarins, higher fatty acids and the absence of flavones aglycone and alkaloids in the leave extract. The activity of the extract was more potent at 30 mgml-1 with zone of growth inhibition against S. aureus (35 mm), Klebsiella spp (28 mm) and A. hydrophila (28 mm). The least activity was on P. aeruginosa (9 mm). The minimum inhibitory concentration (MIC) of the extract was 2.09 mgml-1 on Klebsiella spp and S. aureus while 4.17 mgml-1 on Salmonella spp and A. hydrophila. Similarly, the minimal bactericidal concentration (MBC) was 2.09 mgml-1 on S. aureus and 4.17 mgml-1 on Klebsiella spp. however, higher MIC and MBC of 16.67 mgml-1 were observed on P. aeruginosa. The spectra of activities displayed by the extract can be attributed to the presence of these phytochemicals which signifies the potential of S. Kunthianum as a source of therapeutic agents. This therefore, supports the traditional medicinal use of S. kunthianum in Zaria, Nigeria.