Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Targeting Therapy against EGFR Family in Breast Cancer: Progress and Future Potentials

The epidermal growth factor receptor (EGFR) family contains four transmembrane tyrosine kinases (EGFR1/ErbB1, Her2/ErbB2, Her3/ErbB3 and Her4/ErbB4) and 13 secreted polypeptide ligands. EGFRs are overexpressed in many solid tumors, including breast, pancreas, head-and-neck, prostate, ovarian, renal, colon, and non-small-cell lung cancer. Such overexpression produces strong stimulation of downstream signaling pathways, which induce cell growth, cell differentiation, cell cycle progression, angiogenesis, cell motility and blocking of apoptosis.The high expression and/or functional activation of EGFRs correlates with the pathogenesis and progression of several cancers, which make them attractive targets for both diagnosis and therapy. Several approaches have been developed to target these receptors and/or the EGFR modulated effects in cancer cells. Most approaches include the development of anti-EGFRs antibodies and/or small-molecule EGFR inhibitors. This review presents the state-of-the-art and future prospects of targeting EGFRs to treat breast cancer.
Anti‐viral effects of interferon‐λ3 on hepatitis B virus infection in cell culture

Interferon (IFN)‐λ3 is known to have antiviral effects against various pathogens. Recently, it has been reported that the production of IFN‐λ3 in colon cells after the administration of nucleotide analogs is expected to reduce hepatitis B surface antigen in chronic hepatitis B patients. Here, we aimed to prove the antiviral effects of IFN‐λ3 on hepatitis B virus (HBV) by using an in vitro HBV production and infection system.
The Effect of Marine n-3 Polyunsaturated Fatty Acids on Heart Rate Variability in Renal Transplant Recipients: A Randomized Controlled Trial

Resting heart rate (rHR) and heart rate variability (HRV) are non-invasive measurements that predict the risk of sudden cardiac death (SCD). Marine n-3 polyunsaturated fatty acid (PUFA) supplementation may decrease rHR, increase HRV, and reduce the risk of SCD. To date, no studies have investigated the effect of marine n-3 PUFA on HRV in renal transplant recipients. In a randomized controlled trial, 132 renal transplant recipients were randomized to receive either three 1 g capsules of marine n-3 PUFA, each containing 460 mg/g EPA and 380 mg/g DHA, or control (olive oil) for 44 weeks. HRV was calculated in the time and frequency domains during a conventional cardiovascular reflex test (response to standing, deep breathing, and Valsalva maneuver) and during 2 min of resting in the supine position. There was no significant effect of marine n-3 PUFA supplementation on time-domain HRV compared with controls. rHR decreased 3.1 bpm (± 13.1) for patients receiving marine n-3 PUFA compared to 0.8 (± 11.0) in controls (p = 0.28). In the frequency domain HRV analyses, there was a significant change in response to standing in both high and low frequency measures, 2.9 (p = 0.04, 95% CI (1.1;8)) and 2.7 (p = 0.04, 95% CI (1.1;6.5)), respectively. In conclusion, 44 weeks of supplemental marine n-3 PUFAs in renal transplant recipients significantly improved the cardiac autonomic function, assessed by measuring HRV during conventional cardiovascular reflex tests.
Effect of Different Yeast Strains and Temperature of Fermentation on Basic Enological Parameters, Polyphenols and Volatile Compounds of Aurore White Wine

The aim of this study was to investigate the content of phenolics by Ultra Performance Liquid Chromatography–Photodiode Array (UPLC–PDA), and volatile compounds by Gas Chromatography–Mass Spectroscopy (GC–MS), antioxidant capacity by 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS•+) and ferric-reducing antioxidant power (FRAP) assay, and color of Comission Internationale de l’Eclairage system (CIE) L*a*b* cv. Aurora white wine depending on fermentation conditions (a temperature of 12 °C vs. 20 °C and type of natural and commercial yeast (Saccharomyces cerevisiae vs. Saccharomyces bayanus)). The final wine differed in the content of total phenolic compounds (201.0–287.2 mg/L), except for the variants fermented at 20 °C with S. cerevisiae (321.9 and 329.4 mg/L for S. cerevisiae as Challenge Aroma White and SIHA® Cryaroma type, respectively). A decrease in antioxidant activity ranging from 43.3% to 65.4% (ABTS and FRAP assay) in the matured wine vs. must was demonstrated. S. cerevisiae wine was also characterized by the highest content of total volatile compounds (3.7–4.2 mg/L vs. 1.3 mg/L in the must). In general, the wine obtained with S. cerevisiae had higher alcohol content, antioxidant capacity, and was richer in polyphenolic and volatile compounds.
Do Physical Activity, Caloric Intake, and Sleep Vary Together Day to Day? Exploration of Intraindividual Variability in 3 Key Health Behaviors.

BACKGROUND Little is known about how daily fluctuations in health behaviors relate to chronic disease risk. The goal of this study was to examine whether variability in physical activity, caloric intake, and sleep is related to body composition (body mass index and body fat percentage). METHODS Healthy adults (N = 103; 64% female) were monitored for 7 days to assess physical activity (SenseWear Armband), caloric intake (daily food diaries), and sleep duration and timing (Actiwatch Spectrum). Data were analyzed using correlations (between- and within-subjects correlations) and regression. RESULTS The results demonstrated that variabilities in physical activity, caloric intake, and sleep were unrelated. Caloric intake and sleep variability were unrelated to body composition. At greater levels of physical activity variability, any level of physical activity was protective for body composition. CONCLUSIONS These results suggest that among healthy adults, variabilities in health behaviors may be independent of each other, and physical activity variability may be more strongly related to body composition among those who are less active.
An Evaluation of the Clotting Properties of Three Plant Rennets in the Milks of Different Animal Species

Cynara cardunculus, Carica papaya and Ficus carica extracts are proposed as milk coagulants herein. Their coagulation efficiency was measured in bovine, buffalo, goat and sheep milk incubated at different temperatures. The milk-clotting and proteolytic activities as well as the lactodynamographic parameters were determined considering animal rennet as a reference coagulant. The vegetable coagulant, extracted from C. cardunculus pistils, proved to be the most suitable milk-clotting enzyme for cheesemaking, since it possesses similar milk clotting properties to conventional calf rennet. F. carica latex, but seemed to be a promising alternative coagulant at higher temperatures. The strong proteolytic activity of papain caused poor milk coagulation in all milk samples. To conclude, this result also supports the original hypothesis of this study that the excessive proteolytic nature of plant coagulants can negatively affect the cheesemaking process. The optimization of using a plant rennet in a dairy application can be done by selecting the appropriate plant rennet with a consistent clotting efficiency. These innovative manufacturing processes may also lead to the optimization and production of new cheese varieties.
Carbon source requirements for mating and mating‐type switching in the methylotrophic yeasts Ogataea (Hansenula) polymorpha and Komagataella phaffii (Pichia pastoris)

The methylotrophic yeasts Ogataea (Hansenula) polymorpha and Komagataella phaffii (Pichia pastoris) have important industrial applications and are models for several biological processes including peroxisome biology and methanol metabolism. We examined the carbon source requirements for mating‐type (MAT) switching and mating in both species. Haploid strains of O. polymorpha and K. phaffii are homothallic, and switch MAT by a flip/flop mechanism in which a chromosomal region containing the MAT genes undergoes an inversion. MAT switching is induced by nitrogen starvation in both species and can be detected 4–6 hr after induction. Both switching and mating require a utilizable carbon source that can be either fermentable or nonfermentable. We further observed that although methanol can be used as a sole carbon source in both species, it does not support the induction of MAT switching or mating. Our results provide insight into the nutritional cues that influence entry into sexual processes in methylotrophic yeasts that undergo flip/flop MAT switching.
The Perceptual and Aesthetic Aspects of the Music-Paintings Congruence

The purpose of the present study is to investigate the effect of congruence between music and paintings on the aesthetic preference of paintings. Congruence was specified as the similarity in perceived regularity and the complexity of jazz compositions and abstract paintings (the ratings of regularity and complexity in both sets of stimuli were obtained in the pilot study). In the main experiment, 32 participants rated the aesthetic pleasantness of paintings with congruent, incongruent, and no music background. In addition, they rated the music-paintings matching (how well the music goes with the painting). The results show no effect of congruence on aesthetic pleasantness ratings. The effect on the perceived matching was significant; matching is higher in the congruent compared to the incongruent condition. These findings suggest that congruency has a strong effect on the perceptual aspect of the music-paintings compatibility (visuo-auditory similarity) and no effect on the aesthetic aspect (liking).
Errors in Imagined and Executed Typing

In motor imagery (MI), internal models may predict the action effects. A mismatch between predicted and intended action effects may result in error detection. To compare error detection in MI and motor execution (ME), ten-finger typists and hunt-and-peck typists performed a copy-typing task. Visibility of the screen and visibility of the keyboard were manipulated. Participants reported what type of error occurred and by which sources they detected the error. With covered screen, fewer errors were reported, showing the importance of distal action effects for error detection. With covered screen, the number of reported higher-order planning errors did not significantly differ between MI and ME. However, the number of reported motor command errors was lower in MI than in ME. Hence, only errors that occur in advance to internal modeling are equally observed in MI and ME. MI may require more attention than ME, leaving fewer resources to monitor motor command errors in MI. In comparison to hunt-and-peck typists, ten-finger typists detected more higher-order planning errors by kinesthesis/touch and fewer motor command errors by vision of the keyboard. The use of sources for error detection did not significantly differ between MI and ME, indicating similar mechanisms.
Volatile Fatty Acids in Ruminal Fluid Can Be Used to Predict Methane Yield of Dairy Cows

Simple Summary Methane emissions from cattle are difficult to measure, and some proxies used to estimate them have required information that is not always available. An example is predicting methane from the fatty-acid profile of milk, but this strategy is not suitable for non-lactating animals. We propose equations to predict the methane emitted per unit of feed eaten (methane yield) based on the volatile fatty acids within the rumen of the animals. Three of the seven equations we investigated were equally good at predicting the methane yield of dairy cows. Validation of these equations using previously published results indicated that the equations should also work for beef cattle. Being able to predict the methane yield for all classes of cattle means that a single strategy can be used, eliminating differences because of the use of different methods for different animal classes. Further work is necessary, but our strategy should be able to be adapted for use in cattle production environments. Being able to predict the methane of production animals will enable accurate estimates of the methane emissions from those animals, and assessment of strategies to reduce those emissions. Abstract The dry matter intake (DMI) of forage-fed cattle can be used to predict their methane emissions. However, many cattle are fed concentrate-rich diets that decrease their methane yield. A range of equations predicting methane yield exist, but most use information that is generally unavailable when animals are fed in groups or grazing. The aim of this research was to develop equations based on proportions of ruminal volatile-fatty-acids to predict methane yield of dairy cows fed forage-dominant as well as concentrate-rich diets. Data were collated from seven experiments with a total of 24 treatments, from 215 cows. Forage in the diets ranged from 440 to 1000 g/kg. Methane was measured either by open-circuit respiration chambers or a sulfur hexafluoride (SF6) technique. In all experiments, ruminal fluid was collected via the mouth approximately four hours after the start of feeding. Seven prediction equations were tested. Methane yield (MY) was equally best predicted by the following equations: MY = 4.08 × (acetate/propionate) + 7.05; MY = 3.28 × (acetate + butyrate)/propionate + 7.6; MY = 316/propionate + 4.4. These equations were validated against independent published data from both dairy and beef cattle consuming a wide range of diets. A concordance of 0.62 suggests these equations may be applicable for predicting methane yield from all cattle and not just dairy cows, with root mean-square error of prediction of 3.0 g CH4/kg dry matter intake.
How to Motivate Employees for Sustained Innovation Behavior in Job Stressors? A Cross-Level Analysis of Organizational Innovation Climate

The starting point of organizational innovation is employees’ creative thinking and innovation behaviors at work. In addition to personality and innovation willingness, innovation behavior depends on the level of support available in an organizational environment. The data used in this study were collected from 74 R&D teams (418 employee participants) in technology companies in Taiwan, and a multi-level analysis was conducted to investigate the relationships among job stressors, creative self-efficacy, and employees’ sustained innovation behavior, as well as the role of the organizational innovation climate between creative self-efficacy and employees’ innovation behavior. The research findings revealed significant positive relationships between challenge stressors and employees’ sustained innovation behavior, as well as significant negative relationships between hindrance stressors and employees’ sustained innovation behavior, mediation effects of creative self-efficacy on job stressors and employees’ sustained innovation behavior, and moderation effects of the organizational innovation climate on employees’ creative self-efficacy and sustained innovation behavior. An enterprise could place some working-related stress on employees and create a rich internal innovative climate to induce innovation behavior in its members.
Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism

The occurrence of telomere attrition in brain may cause senescence and death of neurons, leading to cognitive decline. Folic acid (FA) has been reported to improve cognitive performance in mild cognitive impairment; however, its association with telomere remains unclear. The study aimed to investigate if alleviation of telomere attrition by FA supplementation could act as a potential mechanism to delay age-related cognitive decline in senescence-accelerated mouse prone 8 (SAMP8). Aged SAMP8 mice were assigned to four treatment groups: FAdeficient diet (FA-D) group, FA-normal diet (FA-N) group, low FA-supplemented diet (FA-L) group and high FAsupplemented diet (FA-H) group. There was also an age-matched senescence-accelerated mouse resistant 1 (SAMR1) control group (Con-R), and a young SAMP8 control group (Con-Y). The results demonstrated that FA supplementation delayed age-related cognitive decline and neurodegeneration in SAMP8 mice. Importantly, this effect could be attributed to the alleviated telomere attrition, which might be interpreted by the decreased levels of reactive oxygen species. Additionally, improved telomere integrity stimulated mitochondrial function via telomere-p53-mithondria pathway, consequently delayed neuronal degeneration. In conclusion, we demonstrate that FA supplementation delays age-related neurodegeneration and cognitive decline in SAMP8 mice, in which alleviated telomere attrition could serve as one influential factor in the process.
Evidence for multiple recombination events within foot-and-mouth disease viruses circulating in West Eurasia.

Phylogenetic studies on foot-and-mouth disease viruses (FMDVs) circulating in the West Eurasian region have largely focused on the genomic sequences encoding the structural proteins that determine the serotype. The present study has compared near complete genome sequences of FMDVs representative of the viruses that circulate in this region. The near complete genome sequences (ca. 7600nt) were generated from multiple overlapping RT-PCR products. These amplicons were from FMDVs belonging to serotypes O, A and Asia-1, including members of the O-PanAsia-II and the A-Iran05 lineages, and of Group-II and Group-VII (Sindh-08) within serotype Asia-1, which are currently predominant and widespread in West Eurasia. These new sequences were analysed together with other sequences obtained from GenBank. Comparison of different regions of the FMDVs genomes revealed evidence for multiple, inter-serotypic, recombination events between FMDVs belonging to the serotypes O, A and Asia-1. It is concluded from the present study that dramatic changes in virus sequences can occur in the field through recombination between different FMDV genomes. These analyses provide information about the ancestry of the serotype O, A and Asia-1 FMDVs that are currently circulating within the West Eurasian region.
No evidence that Y‐chromosome differentiation affects male fitness in a Swiss population of common frogs

The canonical model of sex‐chromosome evolution assigns a key role to sexually antagonistic (SA) genes on the arrest of recombination and ensuing degeneration of Y chromosomes. This assumption cannot be tested in organisms with highly differentiated sex chromosomes, such as mammals or birds, owing to the lack of polymorphism. Fixation of SA alleles, furthermore, might be the consequence rather than the cause of recombination arrest. Here we focus on a population of common frogs (Rana temporaria) where XY males with genetically differentiated Y chromosomes (nonrecombinant Y haplotypes) coexist with both XY° males with proto‐Y chromosomes (only differentiated from X chromosomes in the immediate vicinity of the candidate sex‐determining locus Dmrt1) and XX males with undifferentiated sex chromosomes (genetically identical to XX females). Our study finds no effect of sex‐chromosome differentiation on male phenotype, mating success or fathering success. Our conclusions rejoin genomic studies that found no differences in gene expression between XY, XY° and XX males. Sexual dimorphism in common frogs might result more from the differential expression of autosomal genes than from sex‐linked SA genes. Among‐male variance in sex‐chromosome differentiation seems better explained by a polymorphism in the penetrance of alleles at the sex locus, resulting in variable levels of sex reversal (and thus of X‐Y recombination in XY females), independent of sex‐linked SA genes.
Study of Nurses Quality of Life using WHO Questionnaire in Hospitals of Hamadan University of Medical Sciences

Background & Objectives : Along with theadvancesinmanydifferent levels of life, interest in measuring quality of life has increased. The aim of this study was to assess quality of life in hospitals of Hamadan University of Medical Sciences. Methods : This cross-sectional study was performed on 300 nurses in hospitals of Hamadan University of Medical Sciences during 2012-2013. To determine the quality of life, the WHO questionnaire (WHOQOL-BREF) was used. Data was analyzed using SPSS software version 16. Results : The mean cores on physical and mental health dimensions in men were more than women (Pvalue<0.05). The lowest and the highest rate of quality of life were among dialysis and coronary care unit staffs, respectively. The average scores on the physical dimension was higher in singles than married, however, means cores of the social and psychological dimensions were higher in married. Conclusion : The highest rate of quality of life was related to physical, psychological, social, and environmental dimensions. So, it is recommended that managers take the necessary actions in order to improve the quality of life and health of the people of the community.
Relationship between changes in motor capacity and objectively measured motor performance in ambulatory children with spastic cerebral palsy

Abstract Background Different interventions are offered to children with cerebral palsy (CP) to improve the activity domain of the international classification of functioning (ICF). In therapy settings, the focus is mostly on motor capacity, but the ultimate goal is to improve motor performance. We therefore examined if changes in motor capacity outcomes are accompanied by changes in objectively measured motor performance after a 3‐month intensive treatment period in ambulatory children with CP. Methods A secondary analysis on prospective clinical trial data was performed using multivariate linear regression. Sixty‐five children (37 boys and 28 girls) with spastic CP, mean age 7 years and 3 months, Gross Motor Function Classification System (GMFCS) levels I–III were involved in a distinct 3‐month intensive treatment period. Motor capacity (Gross Motor Function Measure [GMFM], functional muscle strength [FMS], and walking speed [WS]) and motor performance (using three Actigraph‐GT3X+‐derived outcome measures) were measured at baseline, 12 and 24 weeks. Results No significant associations were found for any of the change scores (∆12) between motor capacity and motor performance after a 12‐week intensive treatment period. After 24 weeks, ∆24FMS (p = .042) and ∆24WS (p = .036) were significantly associated with changes in motor performance outcome measure percentage of time spent sedentary (∆24%sedentary). In this model, 16% of variance of ∆24%sedentary was explained by changes in motor capacity (p = .030). Conclusions Changes in motor capacity are mostly not accompanied by changes in objectively measured motor performance after an intensive treatment period for ambulatory children with CP. These findings should be taken into account during goal setting and are important to manage expectations of both short‐ and longer term effects of treatment programmes.
Revolving doors of tendinopathy: definition, pathogenesis and treatment

The ultimate cure for the tendon pathology continues to elude current science. Despite great steps in technology, the causation and treatment is still not clear. The number of different theories and treatment modalities in the literature may confuse clinicians and patients. In this paper we outline the definitions, evolution of pathogenesis and treatment for tendinopathy. By highlighting these, the aim of this paper is to guide the practitioner in counselling and treating their patients.