Miracle-dz/UniFAR-FTUs huggingface dataset:
against cisplatin-induced nephrotoxicity in male rats Histological , ultrastructural and immunohistochemical studies on the protective effect of ginger extract

Cisplatin (CP) is a widely used anticancer drug; however, it has several side effects such as nephrotoxicity. Ginger, the rhizome of Zingiber officinale, consumed since ancient times has numerous health benefits. The objective of this work was to evaluate the protective effect of ginger extract (GE) against CP-induced nephrotoxicity. CP group displayed a marked renal failure characterized by a significant increase in serum creatinine and blood urea nitrogen (BUN) levels in addition to severe histopathological and ultrastructural renal alterations. Also, CP group showed an increase in the immunohistochemical expression of Bax proapoptotic protein. In contrast, GE+CP group showed significant decrease in the elevated serum creatinine and BUN levels and an improvement in the histopathological and ultrastructural renal injury induced by CP. The overexpression of Bax proapoptotic protein was significantly decreased in the GE+CP group. Hence, the present results indicated that GE has a protective effect against CP-induced renal damage in rats. Thereby, such findings recommended the usage of GE to prevent and/or decrease the renal damage induced by CP chemotherapeutic treatment.
Short-Term Load Forecasting Using a Novel Deep Learning Framework

Short-term load forecasting is the basis of power system operation and analysis. In recent years, the use of a deep belief network (DBN) for short-term load forecasting has become increasingly popular. In this study, a novel deep-learning framework based on a restricted Boltzmann machine (RBM) and an Elman neural network is presented. This novel framework is used for short-term load forecasting based on the historical power load data of a town in the UK. The obtained results are compared with an individual use of a DBN and Elman neural network. The experimental results demonstrate that our proposed model can significantly ameliorate the prediction accuracy.
Inference in small cointegrated systems: some Monte Carlo results

The Johansen procedure for testing and estimating cointegration models is analysed from a practitioner's perspective. We adress the robustness of the cointegration tests in small samples and with respect to particular types of misspecification of the model. A small cointegrated system is parameterized and forms the basis for the Monte Carlo simulations. Non-parametric estimates of the distribution of the Trace and )Max tests are reported, as well as for some of the estimators for longand short-run parameters in the model respectively. Power properties and finite sample performance for the cointegration test and estimators are discussed and the results are interpreted in the light of available asymptotics. The types of model misspecification considered include the case with wrong dynamic specification (i.e. wrong order k in the VAR model) and the case when we ignore nonnormality in the DGP residuals (i.e. when the DGP residuals are subject to ARCH (Auto Regressive Conditional Heteroscedasticity) or are serially correlated). We also discuss how data properties like temporal aggregation or systematic sampling may affect the inference on cointegration, and how the Johansen procedure performs under those conditions. Finally, we consider the case with cointegration between non-stationary latent variables which are observed with measurement errors. Inference on cointegration 1
Distribution and habitat partitioning by small odontocetes in the Gully, a submarine canyon on the Scotian Shelf

In this paper we examine the summer distribution of three species of small odontocetes in the highly productive waters in and near the Gully, a submarine canyon on the edge of the Scotian Shelf. Atlantic white-sided dolphins (Lagenorhynchus acutus) and common dolphins (Delphinus delphis) were not randomly distributed with respect to depth, sea-floor relief, month of sighting, or sea-surface temperature. Long-finned pilot whales (Globicephala melas) were not randomly distributed with respect to month or sea-surface temperature. These species used the Gully slightly differently, although there was overlap. White-sided dolphins were seen only in the core of the canyon, but were sighted at all temperatures, depths, and sea-floor reliefs and throughout the summer field season. Common dolphins had a modest range throughout the deeper waters and were not seen in the summer before July, when the water warms. Pilot whales ranged widely over the study area, preferring areas with fairly flat relief and were more com.
Effects of Intramuscular or Bioadhesive Buccal Testosterone Treatment on Antioxidant Systems in Secondary Hypogonadism

From cross-sectional studies in healthy men, lower plasma total testosterone levels seem to be associated with hyperinsulinemia, decreased glucose tolerance, and a higher level of cardiovascular risk factors. Despite in vitro and in vivo experiments suggest a key role of testosterone in modulating antioxidant systems in different tissues, few data are reported in humans. Extending our previous results, we show that treatment with testosterone, both in intramuscular or bioadhesive buccal formulations, increase plasma levels of Coenzyme Q10, lipophilic antioxidant, and total antioxidant capacity, measured with colorimetric method, in patients with secondary hypogonadism. Hypogonadism could represent a condition of oxidative stress, in turn related with augmented cardiovascular risk in such patients.
Aktuelle Therapiemöglichkeiten der Multiplen Sklerose // Therapy options of multiple sclerosis

Therapy options of multiple sclerosis. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, encompassing both neuroinflammatory as well as prominent neurodegenerative aspects. A significant proportion of MS patients will develop neurological disability over time and up until recently licensed drugs could not satisfactorily halt this process. However, in the last years MS treatment has raised a stage of rapid progress. Several new drugs for relapsing remitting MS (RRMS) with improved efficacy have entered the therapeutic field and several others are on the way. In this review, we will summarize pathophysiological apsects of the disease as well as efficacy, safety and tolerability issues of currently licensed drugs for RRMS. Furthermore, new drugs with positive results from phase III clinical trials in RRMS will be highlighted. J Neurol Neurochir Psychiatr 2018; 19 (1): 3–13.
snails exposed to the pesticides diazinon and profenfos alexandrina Biomphalaria Alterations in the fatty acid profile , antioxidant enzymes and protein pattern

The use of pesticides is widespread in agricultural activities. These pesticides may contaminate the irrigation and drainage systems during agriculture activities and pests’ control and then negatively affect the biotic and a biotic component of the polluted water courses. The present study aimed to evaluate the effect of the pesticides diazinon and profenfos on some biological activities of Biomphalaria alexandrina snails such as fatty acid profile, some antioxidant enzymes (thioredoxin reductase (TrxR), sorbitol dehydrogenase (SDH), superoxide dismutase (SOD), catalase (CAT) as well as glutathione reductase (GR) and lipid peroxidation (LP)) and protein patterns in snails’ tissues exposed for 4 weeks to LC10 of diazinon and profenfos. The results showed that the two pesticides caused considerable reduction in survival rates and egg production of treated snails. Identification of fatty acid composition in snail tissues treated with diazinon and profenfos pesticides was carried out using gas–liquid chromatography (GLC). The results declared alteration in fatty acid profile, fluctuation in percentage of long chain and short chain fatty acid contributions either saturated or unsaturated ones, and a decrease in total lipid content in tissues of snails treated with these pesticides. The data demonstrate that there was a significant inhibition in the activities of tissues SOD, CAT, glutathione reductase (GR), TrxR, and SDH in tissues of treated snails, while a significant elevation was detected in LP as compared to the normal control. On the other hand, the electrophoretic pattern of total protein showed differences in number and molecular weights of protein bands due to the treatment of snails. It was concluded that the residues of diazinon and profenfos pesticides in aquatic environments have toxic effects on B. alexandrina snails.
Effect of Bacillus cereus Enzymes on Milk Quality following Ultra High Temperature Processing

Jan‰tova B. , M. Draakova, L.Vorlova: Effect of Bacillus cereus Enzymes on the Milk Quality following Ultra High Temperature Processing. Acta Vet Brno 2006, 75: 601-609. Using a model case of contamination of long-life semi-skimmed milk with the spores of six B. cereus strains, isolated from the farm environment and raw milk, proteolysis was monitored by measuring changes in protein content by infra-red spectroscopy; free tyrosine was measured by the Lowry method according to Juffs, and the reduction in casein fractions by SDS-PAGE. Lipolysis was monitored by the dilution extractive method. At a storage temperature of 4 °C for 4 months no enzyme processes were observed, whereas at a storage temperature of 24 °C a marked enzyme activity was found during maximum 3 weeks as well as sensory changes of UHT milk. After three weeks of storage, a reduction in protein content from 34.55 g·1-1 milk to 29.46 ± 2.00 g·1-1 milk, and a reduction in the free tyrosine from 0.65 to 2.13 ± 0.28 mg·ml -1 was found, as well as increased molar contents of free fatty acids (FFA) from 41.97 to 1617.22 ± 68.17 mmol·kg-1 milk fat. After six days of storage, α-casein, β-casein and κ-casein dropped to 69 ± 10%, 56 ± 16% and 43 ± 10%, respectively. Majority of changes in UHT milk depended on the B. cereus strain used, initial microbial counts and the method of heat inactivation of spores. Bacillus cereus, spores, proteolysis, casein, lipolysis
release properties Bone substitute materials delivering zoledronic acid : Physicochemical characterization , drug load , and

Calcium phosphate-like bone substitute materials have a long history of successful orthopedic applications such as bone void filling and augmentation. Based on the clinical indications, these materials may be loaded with active agents by adsorption offering a perspective for providing innovative drug-delivery systems. The highly effective bisphosphonate zoledronic acid (ZOL) demonstrated a strong affinity to biominerals and is known to significantly reduce osteoclastic activity. Support of early bone formation and reduction of bone resorption can be promoted after implantation of bioceramics releasing ZOL. The aim of this study was to develop an easy to handle approach to combine ZOL with bone substitutes by use of a dipping technique. The properties of three different materials were investigated by using a number of physicochemical methods such as light microscopy, scanning electron microscopy (SEM), dynamic vapor sorption (DVS), true density, and surface area measurement to evaluate the feasibility of being potential drug carriers. Besides physicochemical characterization, the bone substitutes were evaluated by their ZOL-loading capacity in a timeand concentration-dependent manner. Additionally, the materials were assessed as release systems in an in vitro study. A controlled ZOL load in a range of 0.04–1.86 mg/mg material and a release of 0.02–0.18 mg/mg within 30 min is demonstrated. The findings support using the investigated bioceramics as carrier systems to release ZOL. Overall, the results create the base for further development of drug-delivery systems with controlled drug loading and prolonged release and need to be further analyzed in an in vivo study.
Anticipating synchronization of two chaotic laser diodes by incoherent optical coupling and its application to secure communications

We demonstrate anticipating synchronization between two chaotic laser diodes respectively subjected to incoherent optical feedback and incoherent optical injection. We investigate the robustness of the synchronization with respect to small parameter mismatches and spontaneous emission noise. We show that the gain saturation strongly enhances the synchronization quality. We demonstrate that anticipating synchronization can be applied to cryptographic purposes. We check how difficult it is to intercept a message encoded by chaos shift keying without an adequate replica of the transmitter laser. 2002 Elsevier Science B.V. All rights reserved.
An Improved Parallel Interference Cancellation Algorithm in DS/CDMA Communication System

This paper introduces an improved parallel interference cancellation algorithm in a DS/CDMA communication system. Because of the lack of the energy information of interfering signal in the conventional parallel interference cancellation (PIC) algorithm, the detection performance of the weak signals is not improved. The algorithm introduced in this paper takes advantage of the virtue of successive interference cancellation (SIC) algorithm and improves greatly the detection performance of weak signals by reducing the error of multi-access interference estimation through classifying the signals. Bit error rate of this improved algorithm has theoretically been analyzed in detail. Simulation results have been given for a multitude of different situations. Finally, it is concluded that the performance of this new algorithm is more desirable than that of the conventional one
Three-Stage Mining Metals Supply Chain Coordination and Product Quality Improvement with Revenue Sharing Contract

One of the main concerns of miners is to increase the quality level of their products because the mining metals price depends on their quality level; however, increasing the quality level of these products has different costs at different levels of the supply chain. These costs usually increase after extractor level. This paper studies the coordination issue of a decentralized three-level supply chain with one supplier (extractor), one mineral processor and one manufacturer in which the increasing product quality level cost at the processor level is higher than the supplier and at the level of the manufacturer is more than the processor. We identify the optimal product quality level for each supply chain member by designing a revenue sharing contract. Finally, numerical examples show that the designed contract not only increases the final product quality level but also provides a win-win condition for all supply chain members and increases the whole supply chain profit. Keywords—Three-stage supply chain, product quality improvement, channel coordination, revenue sharing.
Core Functions Analysis and Example Deployment of Virtual Honeynet

Honey net technologies play an increasingly important role in network security. However, conventional honey net has some disadvantages like low hardware utilization, complexity configuration and difficultly management increasingly highlighted. Towards solving these problems that honey net currently facing, in this paper, we propose the necessity of using virtual technology to construct honey net. Through the studying on core functions of honey net, the paper analyzed and provided the workflows of core functions in virtual system. Based on that, we designed and implemented a virtual honey net proposal. The results show that the established virtual honey net works well and solves the shortcomings of conventional honey net in a certain extent.
The role of two acidophilic algae as ecological indicators of acid mine drainage sites

Acidic effl uents, emerging from four abandoned mines (Valdarcas, Carris, Adoria and Cerquido) in Northern Portugal were analyzed regarding physical-chemical, mineralogical and ecological characteristics. Such effl uents present distinct properties since they were mobilized from wastes of different primary ores and mining procedures. Results show that acidophilic algal colonization is dominated by Euglena mutabilis and Klebsormidium sp. Abundance and distribution of both algae are related to different intensity of acid mine drainage (AMD) at each mining site. Mineral-alga interactions infl uence metal deposition at Valdarcas and probably contribute to iron mineral precipitation. Euglena mutabilis displayed a preference for schwertmannite-rich AMD precipitates, which may suggest a mineralogical control on algal colonization. Spatial distribution of E. mutabilis can be used to qualitatively assess water quality improvements along the effluent channel.
Weakly nonuniform thermal effects in a porous catalyst: asymptotic models and local nonlinear stability of the steady states

This paper considers a first-order, irreversible exothermic reaction in a bounded porous catalyst, with smooth boundary, in one, two, and three space dimensions. It is assumed that the characteristic reaction time is sufficiently small for the chemical reaction to be confined to a thin layer near the boundary of the catalyst, and that the thermal diffusivity is large enough for the temperature to be uniform in the reaction layer, but that it is not so large as to avoid significant thermal gradients inside the catalyst. For appropriate realistic limiting values of the several nondimensional parameters of the problem, several time-dependent asymptotic models are derived that account for the chemical reaction at the boundary (that becomes essentially impervious to the reactant), heat conduction inside the catalyst, and exchange of heat and reactant with the surrounding unreacted fluid. These models possess asymmetrical steady states for symmetric shapes of the catalyst, and some of them exhibit a rich dynami.
IMPROVING NETWORK PERFORMANCE FOR APPLICATIONS RUNNING OVER WIDE AREA NETWORKS by Yinan

In recent years, research on wide area networks has gradually spread to more and more applications. However, due to bandwidth limitation of wide area networks, it is necessary to tackle with to provide better services for users, while in traditional applications operating within a single region, the link bandwidth is no concern. In this thesis, we propose and implement different routing algorithms for two types of applications, delay-sensitive applications and streaming analytics applications, respecting their own demands and working conditions. For applications with stringent requirements on latency, we implement our delay-optimized routing mechanisms to minimize packet delay explicitly for applications with high priorities. We then concentrate on streaming analytics application, which is another popular topic recently. On the basis of existing batch-based stream processing system, Spark Streaming, we propose an algorithm jointly considering query routing and batch sizing to exploit detoured high-bandwidth links.
D ec 2 01 5 Horizon Shells and BMS-like Soldering Transformations

We revisit the theory of null shells in general relativity, with a particular emphasis on null shells placed at horizons of black holes. We study in detail the considerable freedom that is available in the case that one solders two metrics together across null hypersurfaces (such as Killing horizons) for which the induced metric is invariant under translations along the null generators. In this case the group of soldering transformations turns out to be infinite dimensional, and these solderings create non-trivial horizon shells containing both massless matter and impulsive gravitational wave components. We also rephrase this result in the language of Carrollian symmetry groups. To illustrate this phenomenon we discuss in detail the example of shells on the horizon of the Schwarzschild black hole (with equal interior and exterior mass), uncovering a rich classical structure at the horizon and deriving an explicit expression for the general horizon shell energy-momentum tensor. In the special case of BMS-like soldering supertranslations we find a conserved shell-energy that is strikingly similar to the standard expression for asymptotic BMS supertranslation charges, suggesting a direct relation between the physical properties of these horizon shells and the recently proposed BMS supertranslation hair of a black hole.
A Dynamic SQL Injection Vulnerability Test Case Generation Model Based on the Multiple Phases Detection Approach

SQL Injection Vulnerability (SQLIV) is one of the topmost serious threats to web applications. Penetration test is one of the most important approaches to detect SQLIV. The test case generation issue critically affects the effectiveness of penetration test. Thus, research on the approaches to improve coverage and efficiency of test case generation process in SQLIV penetration test is of great importance. This paper proposes a formalized SQLIV test case generation model. i) We propose Global Test Rule (GTR), which is used to generate test cases in the process of SQLIV detection. ii) We present SQL injection vulnerability Test Matrix (SQLTM) model, which is a three dimensional matrix, to generate the set of GTR. iii) Based on the GTR generated by the above steps, we propose a Multiple Phases Detection Approach (MPDA) to implement the dynamic generation of test cases and detection procedure control, and then we give its algorithms in detail. Experiment results show that our approach can improve the coverage, precision and efficiency of SQLIV detection by a comparison with two real products for enterprise projects.
Turchin An Experimental Test Dynamical Role of Predators in Population Cycles of a Forest Insect :

clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): August 2, 2012 www.sciencemag. org (this information is current as of The following resources related to this article are available online at http://www.sciencemag.org/content/285/5430/1068.full.html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/content/285/5430/1068.full.html#ref-list-1 , 1 of which can be accessed free: cites 13 articles This article 68 article(s) on the ISI Web of Science cited by This article has been http://www.sciencemag. org/content/285/5430/1068.full. html#related-urls 2 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag. org/cgi/collection/ecology Ecology subject collections: This article appears in the following
Cooperative Small Group Discussion

Although small group discussion is a familiar activity used in ESUEFL classrooms, it has limitations resulting from its control-free nature. This activity has been made more struc­ tured by incorporating the three basic principles of Coopera­ tive Learning, a teaching methodology based on the belief that learning increases as cooperation among learners develops. This article first provides theoretical background for the use of group work and then describes how those three principles can be applied to the activity. Finally students' reactions to Cooperative Small Group Discussion are discussed, and sug­ gestions as to the use of this activity are offered. te,fii. )~Jv-:f71 ' A:h';lY3:"~~-~f1~~~V3~~,~O Om •• ~~l , ~ &? :iftT ~ 0 *rnB,;t, ~ T, ~oom~fi~;:jOt}~ ~·)v-~? -~ O)~IDfif~iJ'1rfH ;: ~v:\LIDfift; 00 ~~;:, t6hlQ1~fiO)=-~O) Jl{J{U~It~:b~~;: ~mO) ~ '7 ~ ~;:~ m~~~~~~. O)~f~~~~ L~To ~h~~,~. ~~~~~~ t. :~fjii:b~ :. 0) J=i1t>, ~ t+ oj t ~ X. L It:\ < :b~ ~ 7 ~ 7' - ,,~:it0)k6* ~~ ~;:iifr 0, ~~~~;:, l ~ 5i}]*J19~;::' 0)J=i7*~ mlt~ ~ t. : bbo)~~~ It:\ < ~