Miracle-dz/UniFAR-FTUs huggingface dataset:
Transparent reporting of studies relevant to physical therapy practice.

BACKGROUND There was a clear grow, in the last 2 decades, of up to 6 fold in scientific articles that are directly relevant to physical therapy practice. However, along with this fast grow; little attention has been given to transparency when reporting research methods and results. More recently, groups of researchers around the world have made successful attempts to address this issue by creating guidelines that will help researchers not only on the preparation of manuscripts but also on making sure that important details related to design and methodology are controlled and reported. OBJECTIVE To present four specific reporting guidelines, which are best known as "statements". DISCUSSION A network named EQUATOR (Enhancing the Quality and Transparency of Health Research) was created with the main mission of providing basic principles for responsible and transparent reporting. The EQUATOR network encompasses, among others, the CONSORT statement which is related to randomized controlled trials; the PRISMA statement, which is related to systematic reviews and meta-analysis; the STROBE Statement, which is related to observational studies; and the STARD statement, which is related to reporting of accuracy of diagnostic tests. Some journals have recommended the use of these statements, while in others their use is mandatory. The goal of the use of these statements by journals is to guarantee fast decisions regarding publication and the best possible quality of reporting. Ultimately, it will help readers, including physical therapists, to make better decisions in clinical practice.
Online Learning: Improving the Learning Outcomes

The use of Technology to facilitate better learning and training is gaining momentum worldwide, reducing the temporal and spatial problems associated with traditional learning. Despite its several benefits, retaining students in online platforms is challenging. This paper discusses an integration of online learning with virtual communities and mobile platforms to foster student engagement for obtaining better learning outcomes in blended learning platforms as well as to understand the public sentiments regarding the pure online learning platforms and finding the factors to improve the learning outcome. The potential utility of the study is discussed in terms of the contribution to the theory and practice.
Univer6 - A Universal Network Architecture for IPv6

IPv6 transition is becoming an important research topic recently. In traditional architecture, transition mechanisms are closely connected with application, protocol stack, and network equipments. This makes the transition process very complicated, and increases the difficulty of network management. In this paper, we present a new network architecture called Univer6. It uses IPv6 as a unified middle layer, thus can adapt to various kinds of applications and network equipments. Univer6 will help provide a smooth transition towards IPv6, simplify network management process, and accelerate the development of IPv6.
Direct mapping of adeno-associated virus capsid proteins B and C: a possible ACG initiation codon.

The three major capsid proteins of adeno-associated virus type 2 (AAV2) virions are designated A, B, and C and have molecular sizes of 90, 72, and 60 kDa, respectively. These proteins are related, and genetic studies have shown they are encoded by a long open reading frame located in the right half of the genome. The coding capacity distal to the first ATG in this reading frame is only 503 amino acids (i.e., a protein about the size of protein C), but an open frame sequence devoid of ATG codons extends upstream for an additional 184 codons. Although the amino terminus of the C capsid protein is blocked, partial amino acid sequence analyses of peptides from C have confirmed that it is encoded within the portion of the reading frame distal to the first ATG at nucleotide (nt) location 2810. The amino terminus of the B capsid protein is not blocked, and its sequence begins with alanine. The triplet encoding this alanine lies 64 codons upstream from the initiation site for protein C and is immediately preceded by the threonine codon, ACG, at nt 2615. This ACG codon lies in the most favorable sequence context for protein synthesis initiation. All three AAV2 capsid proteins are labeled in vitro with formyl[35S]methionyl-tRNAf, indicating that synthesis of each protein is initiated independently. Our data suggest that the nt 2615 ACG codon directs the methionyl-tRNA-dependent initiation of the AAV2 B capsid protein. Proteins B and C may be synthesized from the same mRNA species and their relative abundance could be determined by the efficiencies of their respective initiation codons.
Orodigital Pemphigus Vulgaris: A Pathogenic Role of Anti-Desmoglein-3 Autoantibodies in Pemphigus Paronychia?

Paronychia is a rare complication of pemphigus vulgaris (PV), and the immunological profile of patients with digital disease has not been assessed so far. We report 2 cases of PV with oral mucosa and periungual involvement, who had high titers of anti- desmoglein (Dsg)-3 circulating antibodies. These observations raise the possibility that expression of Dsg-1 and Dsg-3 in distinct areas of periungual skin is disease specific and that anti-Dsg-3 antibodies alone may have an as yet unrecognized importance for the development of paronychia in PV.
Approximate Indexed Lists

Let the position of a list element in a list be the number of elements preceding it plus one. Anindexed listsupports the following operations on a list: Insert; delete; return the position of an element; and return the element at a certain position. The order in which the elements appear in the list is completely determined by where the insertions take place; we do not require the presence of any keys that induce the ordering.We considerapproximate indexed listsand show that a tiny relaxation in precision of the query operations allows a considerable improvement in time complexity. The new data structure has applications in two other problems; namely,list labelingandsubset rank.
Class imbalance problem using a hybrid ensemble approach

This paper proposes a comparative study that investigates the effects of using resampling (undersampling and over- sampling) methods with homogenous ensemble methods Bagging and AdaBoost in imbalanced data sets. We presented a hybrid ensemble approach that combined multi resampling by integrating both undersampling and oversampling to get benefits and reduces drawbacks caused by each of them. The proposed approach has improved the performance even those most sensitive to imbalanced class data sets.
A quantitative ultrastructural analysis of satellite cells in denervated fast and slow muscles of the mouse

Mononucleated cells located between the external lamina and sarcolemma of denervated muscle fibers within the extensor digitorum longus (EDL) and soleus muscles of adult mice were quantified and examined ultrastructurally from 3 to 65 days after ligating and removing a section of the sciatic nerve. During the first 2 weeks postdenervation, mononucleated cells in denervated muscles were morphologically indistinguishable from satellite cells observed in control muscles. With time, however, many of these satellite‐like cells appeared more active as evidenced by a decrease in their nucleocytoplasmic ratio and an increase in their mean percentage of euchromatin material. The number of satellite cells (expressed as a ratio of satellite cell nuclei to satellite cell nuclei plus myonuclei) did not increase significantly until 30 days postdenervation, at which time the mean percentage for the soleus muscle had risen from a control value of 4.1–8.5%, and for the EDL from 1.2–4.1%. Smalldiameter, presumably regenerating, myofibers were occasionally observed but only after 30 days denervation. The ultrastructural evidence plus comparisons of euchromatin distributions between myonuclei and satellite cell nuclei support the concept that an increase in the number of satellite‐like cells during denervation is more likely due to satellite cell proliferation than to the formation of mononucleated fragments utilizing preexisting myonuclei.
Revision of Outcomes and Complications Following Open Reduction, and Zigzag Osteotomy Combined with Fibular Allograft for Developmental Dysplasia of the Hip in Children

Background: Reports of the efficacy of open reduction and Zigzag Osteotomy combined Fibular Allograft (ZOFA) for developmental dysplasia of the hip. The purposes of this study were to evaluate the long-term outcomes and complications after surgery. Methods: We performed a retrospective match-controlled study in which 158 patients had 181 hips with developmental dysplasia of the hip. Radiographs were found of acetabular index, height of dislocation, Tonnis grade, abduction angle in the spica cast, and Severin grade. At final follow-up, deformity of femoral head or neck or acetabulum was evaluated according to the Severin. Avascular necrosis was rated according to Kalamchi. Clinical evaluation was made according to modified McKay criteria. Results: Between 2009 and 2012, 133 girls (84.2%) and 25 boys (15.8%) with developmental dysplasia of the hip underwent open reduction and ZOFA; 135 (85.4%) were unilateral, and 23 (14.6%) were bilateral. Patients were divided into 2 groups: group 1 included 54 patients (62 hips) aged 12 months - ≤18 months and group 2 included 84 patients (119 hips), aged >18 months - ≤36 months. According to Tonnis system: type 3 appeared in 127 hips (70.2%), and Type 4 in 54 hip (29.8%). The anterior approach was used to expose inner table of the ilium and ZOFA in all cases. Acetabular index was improved; preoperation was 42.95°, and latest follow-up 17.26°. The Kirschner Wires (KW) were not used to fix the fibular allograft at the pelvic osteotomy site. All of the fibular allografts were completely incorporated in mean time of 14 weeks (range, 12 weeks - 17 weeks) post-surgery. Clinical evaluation according to modified McKay criteria: satisfactory result (excellent and good) was achieved in 141 hips (77.9%). Avascular Necrosis (AVN) happened in 61 hips (33.7%), redislocation in 18 hips (9.9%), coxa vara in 4 hips (2.2%), trendelenburg gait in 4 hips (2.2%), and supracondylar femoral fractures in 2 hips (1.1%). Conclusions: On the basis of this study, ZOFA was strength and graft was not resorption, graft problems; without medial displacement of the distal fragment. Acetabular index was improved, without KW problem. Surgical technique with ZOFA did not expose outer table of the illium, limiting abductor muscle injury with negative trendelenburg gait; on the other hand, the blood loss from this procedure is acceptable. Some complications have been seen in this study: AVN, redislocation, coxa magna, coxa vara, trendelenburg gait, and distal femoral fracture.
A layered architecture for aspect oriented runtime environment

Separation of Concerns' in the field of Software Engineering has been an important issue for quite some time. And this issue is very much related to Aspect Oriented Software Development. This is so because Aspects happen to be certain concerns that get interleaved with the Core-Functionalities in such a way that they become inseparable. As a result of which the coder, who is supposed to be concerned only with the Core-Functionalities, is bound to take extra burden or botheration regarding the proper and accurate handling of Aspects. This paper proposes a Layered-Runtime-Architecture for the Aspect Oriented Execution Environment. The proposed model makes an effort towards Separation of such Interleaving Concerns into separate layers of the execution environment, bringing about significant Clarity, Flexibility and Extendibility in the whole system. The paper also presents a comparative study for the benefits that the new architecture brings about and also the limitations against existing practices.
Pathway Evolution by Horizontal Transfer and Positive Selection Is Accommodated by Relaxed Negative Selection upon Upstream Pathway Genes in Purple Bacterial Carotenoid Biosynthesis

ABSTRACT Horizontal gene transfer and selection are major forces driving microbial evolution. However, interactions between them are rarely studied. Phylogenetic analyses of purple bacterial carotenoid biosynthesis genes suggest two lineages: one producing spheroidenone and the other producing spirilloxanthin. Of the latter lineage, Rubrivivax gelatinosus S1 and Hoeflea phototrophica DFL-43 also or instead produce spheroidenone. Evolution of the spheroidenone pathway from that producing spirilloxanthin theoretically requires changes in the substrate specificity of upstream pathway enzymes and acquisition of a terminal ketolase (CrtA). In R. gelatinosus and likely also in H. phototrophica, CrtA was acquired from the Bacteroidetes, in which it functions as a hydroxylase. Estimation of nonsynonymous and synonymous mutations using several pairwise methods indicated positive selection upon both genes, consistent with their functional changes from hydroxylases to ketolases. Relaxed negative selection upon all other carotenoid biosynthetic genes in these organisms was also apparent, likely facilitating changes in their substrate specificities. Furthermore, all genes responsible for terminal carotenoid biosynthetic pathway steps were under reduced negative selection compared to those known to govern biosynthetic pathway specificity. Horizontal transfer of crtA into R. gelatinosus and H. phototrophica has therefore likely been promoted by (i) the apparent selective advantage of spheroidenone production relative to spirilloxanthin production, (ii) reduced negative selection upon other carotenoid biosynthetic genes, facilitating changes in their substrate specificities, and (iii) preexisting low enzyme substrate specificities due to relaxed negative selection. These results highlight the importance and complexity of selection acting upon both a horizontally transferred gene and the biochemical network into which it is integrating.
ERGODICITY, MIXING, AND EXISTENCE OF MOMENTS OF A CLASS OF MARKOV MODELS WITH APPLICATIONS TO GARCH AND ACD MODELS

This paper studies a class of Markov models that consist of two components. Typically, one of the components is observable and the other is unobservable or “hidden. ” Conditions under which geometric ergodicity of the unobservable component is inherited by the joint process formed of the two components are given. This implies existence of initial values such that the joint process is strictly stationary and β-mixing. In addition to this, conditions for the existence of moments are also obtained, and extensions to the case of nonstationary initial values are provided. All these results are applied to a general model that includes as special cases various first-order generalized autoregressive conditional heteroskedasticity (GARCH) and autoregressive conditional duration (ACD) models with possibly complicated nonlinear structures. The results only require mild moment assumptions and in some cases provide necessary and sufficient conditions for geometric ergodicity.
Premature ovarian failure from current perspective

Premature ovarian failure (POF) is a syndrome characterised by amenorrhoea, hypoestrogenism and hypergonadotropinism before the age of 40. It is a disorder affecting approximately 1% of women <40 years, 1/1,000 women by the age of 30 and 1/10,000 women by the age of 20. POF is not merely an early menopause. Up to 50% of the patients with POF will have intermittent and unpredictable ovarian function which may persist for some years. Heterogeneity of POF is also reflected by the variety of possible causes, including autoimmunity, toxics, drugs, radiation, infectious as well as genetic defects. HRT remains the cornerstone of treatment and the only proven method of achieving pregnancy in these patients is by ovum donation.
A double‐blind, randomized, crossover trial of pemoline in fatigue associated with multiple sclerosis

Fatigue occurs in a majority of patients with MS and is generally independent of measurable neurologic disability. Few options for treatment are available. We conducted a double-blind, placebo-controlled, crossover trial for each of two 4-week treatment periods. Forty-six eligible patients entered and five dropped out due to concurrent exacerbations. Nineteen patients (46.3%) experienced excellent or good relief of fatigue with pemoline, and eight patients (19.5%) with placebo (p = 0.06, Fisher's exact test). One-fourth of patients did not tolerate the drug well, and 7% had to discontinue pemoline during the study due to side effects. The most common side effects were anorexia, irritability, and insomnia. Pemoline may be an effective short-term treatment for fatigue associated with MS, but its adverse effects are not well tolerated by many patients.
The Impact of Social Stressors and Social Networks on Pediatric Medical Care Use

Substantial differences in the use of pediatric medical resources reinforce the need for identifying and understanding factors that influence the use of medical services for children. This research assesses the simultaneous impact of sociodemographic characteristics, health attitudes and beliefs, psychologic distress, social stressors, and social networks on the use of pediatric acute care services during a 12-month period. Using a prospective longitudinal study design, data were obtained on 513 children and their families enrolled in a prepaid group practice. Linear modeling results showed that health attitudes and social networks were important predictors of acute care utilization in addition to child's age, birth order, baseline health status, and ethnic group. The authors were able to show significant effects for network size, dispersion, and tendency to use one's network members. Individuals with large nondispersed networks are more likely to use pediatric health services, apparently due to the transmission of the networks' pro-medical care health beliefs. Also the tendency to call on network members modifies an individual's propensity to seek care for minor pediatric medical problems and can make a difference by as much as 1.6 visits per year per child for acute care episodes.
An online test microstructure for thermal conductivity of surface-micromachined polysilicon thin films

An online test structure for measuring the thermal conductivity of surface micromachined polysilicon thin films is presented. In the structure, a pair of microstructures, i.e., a reference structure and a test structure, are used. The surface micromachined structures are heated electrically. Heat dissipation by convection, radiation, and heat transfer through the air gap and into the substrate is considered in an electrothermal model. The model is confirmed by ANSYS Software. In experiments, current-voltage measurements are only required, and all measurements can be carried out in free air. The surface-micromachined and p-doped polysilicon thin films with a sheet resistance 116.25 /spl Omega//sq. are measured to have a thermal conductivity 28.7 W/mK at 300 K.
Control of chitin synthesis through Shc1p, a functional homologue of Chs4p specifically induced during sporulation

The Saccharomyces cerevisiae SHC1 gene encodes a protein with a high homology to Chs4p, a positive regulator of chitin synthase III (CSIII) during vegetative growth. SHC1 is not expressed during vegetative growth but is strongly induced during sporulation as a mid‐late gene. shc1/shc1 mutants do not show any defect in the total rate of sporulation and meiosis occurs normally. However, shc1/shc1 ascospores be‐come highly permeable to DAPI, much more sensitive to glusulase treatment, and have very low levels of chitosan in their cell walls. All these observations indicate that Shc1p is required for proper maturation of the ascospore through its participation in the synthesis of the chitosan layer. Lack of SHC1 during sporulation can be partially compensated by over‐expression of the CHS4 gene. During vegetative growth, SHC1 has no apparent function but, when ectopically overexpressed, it can substitute Chs4p as an activator of the CSIII activity; however, Shc1p fails to localize it properly, as Chs4p does. In conclusion, S. cerevisiae contains two functionally redundant genes in the control of CSIII activity: CHS4, whose function is restricted to vegetative growth because Chs4p is rapidly degraded during sporulation, and SHC1, whose function in cell wall ascospore assembly is transcriptionally restricted to the sporulation process.
Temporal distribution of information for human consonant recognition in VCV utterances

Abstract The temporal distribution of perceptually relevant information for consonant recognition in British English VCVs is investigated. The information distribution in the vicinity of consonantal closure and release was measured by presenting initial and final portions, respectively, of naturally produced VCV utterances to listeners for categorization. A multidimensional scaling analysis of the results provided highly interpretable, four-dimensional geometrical representations of the confusion patterns in the categorization data. In addition, transmitted information as a function of truncation point was calculated for the features manner place and voicing. The effects of speaker, vowel context, stress, and distinctive feature on the resulting information distributions were tested statistically. It was found that, although all factors are significant, the location and spread of the distributions depends principally on the distinctive feature, i.e., the temporal distribution of perceptually relevant information is very different for the features manner, place, and voicing.
Redundancy of signal and anchor functions in the NH2-terminal uncharged region of influenza virus neuraminidase, a class II membrane glycoprotein

Class II membrane glycoproteins share a common topology of the NH2 terminus inside and the COOH terminus outside the cell. Their transport to the cell surface is initiated by the function of a single hydrophobic domain near the NH2 terminus. This functional domain serves both as an uncleaved signal sequence and as a transmembrane anchor. We examined the signal and anchor functions of influenza virus neuraminidase, a prototype class II membrane glycoprotein, by deletion analysis of its long, uncharged amino-terminal region. The results presented here show that the entire stretch of 29 uncharged amino acids (7 to 35) is not required for either a signal sequence or an anchor sequence function. On the basis of translocation and membrane stability data for different mutants, we suggest that the first 20 amino acid residues (7 to 27) are likely to provide the hydrophobic core for these functions and that within this putative subdomain some sequences are more efficient than the other sequences in providing a translocation function. Finally, it appears that neuraminidase and its mutant proteins are translocated with the proper orientation, regardless of the characteristics of the flanking sequences.
InGaN/GaN Laser Diodes With High Order Notched Gratings

We report on InGaN/GaN distributed feedback laser diodes with high order gratings emitting at a single wavelength around 428 nm. The 39th order notched gratings have the advantage of a simplified fabrication route with no need for overgrowth. The laser ridge and grating were formed by electron beam lithography followed by ICP etching. The as-cleaved lasers emitted in the pulsed regime with a peak single-mode output power of 15 mW. Optimization of the grating design should lead to higher power single wavelength operation.