Miracle-dz/UniFAR-FTUs huggingface dataset:
Apoptosis and Delayed Neuronal Damage after Carbon Monoxide Poisoning in the Rat

Delayed neurological damage after CO hypoxia was studied in rats to determine whether programmed cell death (PCD), in addition to necrosis, is involved in neuronal death. In rats exposed to either air or CO (2500 ppm), microdialysis in brain cortex and hippocampus was performed to determine the extent of glutamate release and hydroxyl radical generation during the exposures. Groups of control and CO-exposed rats also were tested in a radial maze to assess the effects of the CO exposures on learning and memory. At 3, 7, and 21 days after CO exposure brains were perfusion-fixed and hematoxylin-eosin (H&E) was used to assess injury and to select regions for further examination. DNA fragmentation was sought by examining cryosections with the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL) reaction. We found significant increases in glutamate release and . OH generation during and immediately after CO hypoxia. CO-exposed rats showed learning and memory deficits after exposure associated with heterogeneous cell loss in cortex, globus pallidus, and cerebellum. The frontal cortex was affected most seriously; the damage was slight at Day 3, increased at Day 7, and persistent at Day 21 after CO exposure. TUNEL staining was positive at all three time points, and TUNEL-labeled cells were distributed similarly to eosinophilic cells. The number of cells stained by TUNEL was less than by H&E and amounted to 2 to 5% of all cell nuclei in regions of injury. Ultrastructural features of both neuronal necrosis and apoptosis also were observed readily by electron microscopy. These findings indicate that both necrosis and apoptosis (PCD) contribute to CO poisoning-induced brain cell death.
Gene Expression in the Human Endolymphatic Sac: The Solute Carrier Molecules in Endolymphatic Fluid Homeostasis

Objectives/Hypothesis The purpose of the present study is to explore, demonstrate, and describe the expression of genes related to the solute carrier (SLC) molecules of ion transporters in the human endolymphatic sac. Study Design cDNA microarrays and immunohistochemistry were used for analyses of fresh human endolymphatic sac tissue samples. Methods Twelve tissue samples of the human endolymphatic sac were obtained during translabyrinthine surgery for vestibular schwannoma. Microarray technology was used to investigate tissue sample expression of solute carrier family genes, using adjacent dura mater as control. Immunohistochemistry was used for verification of translation of selected genes, as well as localization of the specific protein within the sac. Results An extensive representation of the SLC family genes were upregulated in the human endolymphatic sac, including SLC26a4 Pendrin, SLC4a1 sodium-bicarbonate transporter, SLC9a2 sodium-hydrogen transporter, SLC12a3 thiazide-sensitive Na-Cl transporter, and SLC34a2 sodium-phosphate transporter. Conclusions Several important ion transporters of the SLC family are expressed in the human endolymphatic sac, including Pendrin, the thiazide-sensitive Na-Cl transporter, and the Na-phosphate transporter SLC34a2. The data provide a new knowledge base considering the ion-dependent metabolic mechanisms maintaining inner ear homeostasis. More specifically, the results indicate a strong similarity with the ion transportation occurring in the kidney collecting ducts. In addition, the findings prompt a revision of the theories behind contemporary pharmacological treatment of Ménière’s disease and may broaden the understanding of the pathogenesis of BPPV.
Single‐voxel proton MRS of the human brain at 1.5T and 3.0T

Single‐voxel proton spectra of the human brain were recorded in five subjects at both 1.5T and 3.0T using the STEAM pulse sequence. Data acquisition parameters were closely matched between the two field strengths. Spectra were recorded in the white matter of the centrum semiovale and in phantoms. Spectra were compared in terms of resolution and signal‐to‐noise ratio (SNR), and transverse relaxation times (T2) were estimated at both field strengths. Spectra at 3T demonstrated a 20% improvement in sensitivity compared to 1.5T at short echo times (TE = 20 msec), which was lower than the theoretical 100% improvement. Spectra at long echo times (TE = 272 msec) exhibited similar SNR at both field strengths. T2 relaxation times were almost twofold shorter at the higher field strength. Spectra in phantoms demonstrated significantly improved resolution at 3T compared to 1.5T, but resolution improvements in in vivo spectra were almost completely offset by increased linewidths at higher field. Magn Reson Med 45:765–769, 2001. © 2001 Wiley‐Liss, Inc.
Diagnostic utility of CSF soluble CD27 for primary central nervous system lymphoma in immunocompetent patient

Abstract The aim of this study is to determine the diagnostic utility of cerebrospinal fluid (CSF) soluble CD27 (sCD27) as a tumor marker for primary central nervous system lymphoma (PCNSL) in immunocompetent patients. A total of 93 CSF samples were collected from the following four patient groups: the PCNSL group, 13 patients (26 samples) with PCNSL, 12 samples obtained at initial diagnosis, 10 during therapy, four at complete remission; the other brain tumors (OBT) group, 30 patients (30 samples) with other brain tumors; the other neurological diseases (OND) group, 25 (25 samples) with other neurological diseases; the inflammatory neurological diseases (IND) group, 12 patients (12 samples) with inflammatory neurological diseases. sCD27 levels were determined by sandwich enzyme-linked immunosorbent assay. The optimal cut-off value was found to be 15 U ml~1. The CSF sCD27 levels were over 15 U ml~1 in 23 of the 26 PCNSL samples and were significantly higher than those in the OBT and OND groups in which all samples were below 15 U ml~1. Elevated CSF sCD27 levels were also observed in 11 of 12 IND samples. In the two PCNSL patients whose CSF sCF27 levels were studied longitudinally, the sCD27 levels correlated very well with remission and relapse of the disease. CSF sCD27 is useful as a tumor marker for PCNSL in immunocompetent patients, and is also useful to evaluate the effect of various types of treatment. Although there was a large cross-reactivity in the CSF sCD27 levels between PCNSL and IND group, white blood cell count in the CSF is helpful to distinguish these two diseases. [Neurol Res 2000; 22: 434-442]
Recognizing Women Leaders in Fire Science: Revisited

In August, 2018, an editorial in Fire entitled Recognizing Women Leaders in Fire Science was published. This was intended to ignite a conversation into diversity in fire science by highlighting several women leaders in fire research and development. This editorial was released alongside a new Topical Collection in Fire called Diversity Leaders in Fire Science. The response on social media was fantastic, leading to numerous recommendations of women leaders in fire science that had been inadvertently missed in the first editorial. In this editorial, we acknowledge 145 women leaders in fire science to promote diversity across our disciplines. Fire is continually committed to improving diversity and inclusion in all aspects of the journal and welcomes perspectives, viewpoints, and constructive criticisms to help advance that mission.
Attitude measurement and prediction of behavior: an evaluation of conditions and measurement techniques.

The relation of attitude measures to other behavior continues to be problematic. This paper reanalyzes the issue from a methodological point of view. Reconsideration of available evidence suggests that the degree of correspondence observed is at least a function of (1) the measurement technique used, (2) the extent to which the criterion behavior constitutes action within the range of common experience, and (3) the degree to which the criterion behavior represents a repetitive behavioral configuration. Additional data are brought to bear on the issue with the above considerations in mind. Moderate associations are observed between measured attitude and behavior patterns. The magnitudes of these associations are found to vary with the scale construction technique employed.
Overview of maritime research publications by the late Professor Richard O. Goss

ABSTRACT We lost one of the great maritime scholars in 2017—Professor Richard Goss, who is considered one of the founders of maritime economics. He was a pioneer and a most influential leader in establishing the discipline of maritime economics worldwide. This paper revisits his research by examining major issues and assessing his arguments by surveying empirical works that have been conducted after his works in the literature. His economic thoughts are based on laissez-faire, welfare economics, and Marshallian economics. Comparing his arguments with major findings in ensuing research, several research directions are suggested.
On the accuracy of different boundary integral formulations for dielectric bodies using RWG and BC functions

Different formulations of the boundary integral method for dielectric bodies are evaluated on their accuracy. The formulations apply RWG and/or BC functions both as basis functions and as test functions. A systematic evaluation, measuring the order of accuracy of the different formulations, is performed for low-contrast test cases. The conclusion is that for low-contrast dielectric bodies, the CTF and Müller formulation (tested with BC functions) provide the best choice.
An empirical method for prediction of cheese yield.

Theoretical cheese yield can be estimated from the milk fat and casein or protein content of milk using classical formulae, such as the VanSlyke formula. These equations are reliable predictors of theoretical or actual yield based on accurately measured milk fat and casein content. Many cheese makers desire to base payment for milk to dairy farmers on the yield of cheese. In small factories, however, accurate measurement of fat and casein content of milk by either chemical methods or infrared milk analysis is too time consuming and expensive. Therefore, an empirical test to predict cheese yield was developed which uses simple equipment (i.e., clinical centrifuge, analytical balance, and forced air oven) to carry out a miniature cheese making, followed by a gravimetric measurement of dry weight yield. A linear regression of calculated theoretical versus dry weight yields for milks of known fat and casein content was calculated. A regression equation of y = 1.275x + 1.528, where y is theoretical yield and x is measured dry solids yield (r2 = 0.981), for Cheddar cheese was developed using milks with a range of theoretical yield from 7 to 11.8%. The standard deviation of the difference (SDD) between theoretical cheese yield and dry solids yield was 0.194 and the coefficient of variation (SDD/mean x 100) was 1.95% upon cross validation. For cheeses without a well-established theoretical cheese yield equation, the measured dry weight yields could be directly correlated to the observed yields in the factory; this would more accurately reflect the expected yield performance. Payments for milk based on these measurements would more accurately reflect quality and composition of the milk and the actual average recovery of fat and casein achieved under practical cheese making conditions.
Design of High Gain and Low Noise CMOS Gilbert Cell Mixer for Receiver Front End Design

This paper presents the design of a low noise CMOS Gilbert cell mixer in 180 nm technology with the help of cadence tool. The switched biasing technique is used to improve the noise performance by splitting the tail current source into two small transistors. The proposed mixer produces a simulated conversion gain (CG) of 9.95 dB with a noise figure (NF) of about 8.12 dB. The supply voltage required for the circuit is 1.8 V with a power consumption of 3.5 mW. The layout of the present design is also given here. This design results better performance in the conversion gain, noise figure and power consumption than the conventional mixer design available in the literature. Hence, this design is a suitable block for receiver front end design for wireless systems.
Effectiveness for self-monitoring of blood sugar on blood glucose control in Turkish patients with type 2 diabetes mellitus.

AIM Diabetes mellitus (DM) is a chronic disease requiring continuous monitoring and treatment. Self-monitoring of blood glucose (SMBG) is frequently recommended. The purpose of the study was to evaluate effectiveness of SMBG on metabolic control in Turkish patients with type 2 DM. METHODS The cross-sectional study enrolled type 2 diabetic patients without insulin regimen. The participants were assigned to three groups according to status of SMBG: group 1- regular, group 2 - irregular and group 3 - never SMBG implementation. RESULTS A total of 349 patients were enrolled. There was no significant difference in mean fasting and post-prandial blood glucose, lipid profile values between the groups. The number of patients with high education level in group 1 was higher than groups 2 and 3 (p = 0.001). HbA1c level was higher in groups 2 and 3 than group 1, but not significantly (p = 0.285). Mean spot urinary albumin- creatinine ratio (ACR) in group 1 is significantly lower than in groups 2 and 3 (p = 0.008 and p = 0.044, respectively), but no significant difference was observed between group 2 and 3 (p = 0.473). CONCLUSION The study indicated that regular use of SMBG was not superior to irregular/never use of SMBG on glycemic control, but it seemed to be good intervention for prevention of diabetic nephropathy. We suggestively offered that SMBG should be recommended for patients with a high education level to meet the goal of its use, and it should be incorporated into self-management with effective educational intervention.
Design of a low power smart wireless system used for multisensor monitoring

In this work, a design of low power wireless system for multisensors monitoring has been presented. The main purpose of this research is to develop an efficient telemetry system for recording various biomedical signals such as pressure and temperature. The system reads data from two types of sensors, resistive and capacitive. Anderson circuit configuration has been used for resistive sensor, since it offers linear like behavior. The capacitive interface is based on capacitance-frequency-voltage conversion that uses phase lock loop (PLL) to convert the frequency to voltage. Two mechanisms have been adopted to reduce the overall power consumption. These are power scheduling and wakeup circuit for the capacitive interface. The first one is implemented fully by the microcontroller unit (MCU) in order to switch on/off all the system units. A wakeup circuit has been designed to interrupt the MCU when it is in the sleep mode and the capacitive samples are changing significantly
Autotransfusion management during and after cardiopulmonary bypass alters fibrin degradation and transfusion requirements.

UNLABELLED The coagulation-fibrinolytic profile during cardiopulmonary bypass (CPB) has been widely documented. However, less information is available on the possible persistence of these alterations when autotransfusion is used in management of perioperative blood loss. This study was designed to explore the influence of autotransfusion management on intravascular fibrin degradation and postoperative transfusions. Thirty patients, undergoing elective primary isolated coronary bypass grafting, were randomly allocated either to a control group (group A; n=15) or an intervention group (group B; n=15) in which mediastinal and residual CPB blood was collected and processed by a continuous autotransfusion system before re-infusion. Intravascular fibrin degradation as indicated by D-dimer generation was measured at five specific intervals and corrected for hemodilution. In addition, chest tube drainage and need for homologous blood were monitored. D-dimer generation increased significantly during CPB in group A, from 312 to 633 vs. 291 to 356 ng/mL in group B (p = .001). The unprocessed residual blood (group A) revealed an unequivocal D-dimer elevation, 4131 +/- 1063 vs. 279 +/- 103 ng/mL for the processed residual in group B (p < .001). Consequently, in the first post-CPB period, the intravascular fibrin degradation was significantly elevated in group A compared with group B (p = .001). Twenty hours postoperatively, no significant difference in D-dimer levels was detected between both groups. However, a significant intra-group D-dimer elevation pre- vs. postoperative was noticed from 312 to 828 ng/mL in group A and from 291 to 588 ng/mL in group B (p < .01 for both). Postoperative chest tube drainage was higher in the patients from group A, which also had the highest postoperative D-dimer levels. Patients in group A perceived a higher need for transfusions of red cells suspensions postoperatively. These data clearly indicate that autotransfusion management during and after CPB suppresses early postoperative fibrin degradation. KEYWORDS cardiopulmonary bypass, cardiotomy suction, coronary surgery, autotransfusion, fibrin degradation.
Log-optimal portfolio and num\'eraire portfolio under random horizon

This paper considers an initial market model, specified by the pair $(S,\mathbb F)$ where $S$ is its discounted assets' price process and $\mathbb F$ its flow of information, and an arbitrary random time $\tau$. This random time can represent the death time of an agent or the default time of a firm, and in both cases $\tau$ can not be seen before it occurs. Thus, the progressive enlargement of $\mathbb F$ with $\tau$, denoted by $\mathbb G$, sounds tailor-fit for modelling the new flow of information that incorporates both $\mathbb F$ and $\tau$. For the stopped model $(S^{\tau},\mathbb G)$, we describe in different manners and as explicit as possible the numeraire portfolio, the log-optimal portfolio, the log-optimal deflator (which is the dual of the log-optimal portfolio), and we elaborate their duality without any further assumption.
Control, Conflict, and Performance: A Study of U.S.-Chinese Joint Ventures

This study was designed to test empirically the linkages between control, conflict, and performance using a sample of U.S.-Chinese joint ventures established in China during the period of 1979–1989. Data were gathered through a questionnaire survey among U.S. managers and personal interviews with both U.S. and Chinese general managers in the selected joint ventures. Results showed that dominant managerial control exercised by the foreign partner had a positive impact on the perceived joint venture performance. The study identified major areas in which conflict between joint venture partners occurred. Empirical evidence was found that conflict between joint venture partners significantly hindered joint venture performance.
In Situ Compositional Analysis of Acidocalcisomes in Trypanosoma cruzi *

We measured the elemental content of different compartments in Trypanosoma cruzi epimastigotes using quick freezing, ultracryomicrotomy, and electron probe microanalysis. Vacuoles identified by high electron density contained (in units of mmol/kg dry weight ± S.E.) large amounts of phosphorus (1390 ± 13), magnesium (646 ± 19), calcium (171 ± 5), sodium (161 ± 18), and zinc (148 ± 6). No other compartment had appreciable calcium or zinc content. Iron (128 ± 16 mmol/kg) was detected only in vacuoles distinct from the electron-dense vacuoles and other organelles. Incubation of cells for 70 min in culture medium in the presence of ionomycin plus nigericin led to a very significant 3- or 2-fold increase in potassium in the electron-dense vacuoles and the iron-rich vacuoles, respectively, with no significant change in the other elements investigated. This indicated the acidic nature of the vacuoles and demonstrated that the electron-dense vacuoles correspond to what were described previously as acidocalcisomes,i.e. acidic compartments rich in Ca2+. The acidocalcisomes were investigated by separation of epimastigote fractions on Percoll gradients in combination with Triton WR-1339 treatment. This detergent caused a rapid vacuolation; these vacuoles were shown by electron microscopy to be largely transparent, with a diffuse matrix. Percoll gradient fractionation demonstrated decreases in the density of various organelle markers in detergent-treated cells compared with controls. Large decreases in the density of the acidocalcisome and the mitochondrion were seen, as well as smaller decreases in the density of the other markers. Conventional electron microscopy of epimastigotes loaded with gold-labeled transferrin indicated that the endosomal system was separate from vacuoles that probably corresponded to the calcium-containing organelles detected by electron probe microanalysis. The combined results provide evidence that acidocalcisomes are organelles different from lysosomes or other organelles previously described in these parasites.
A Zebra Experiment to Study Plasma Formation by Megagauss Fields

An alternative concept for fusion energy production is magnetized target fusion using metal liners to compress a mixture of magnetic flux and plasma fuel. In liner flux compression experiments, megagauss fields are produced at peak compression that heats the surfaces of aluminum walls of the liner cavity. Some radiation magnetohydrodynamic (MHD) modeling indicates that plasma formation should occur between 3 and 5 MG; however, such modeling depends on assumed material properties, which are a topic of ongoing research. Load hardware and diagnostics have been developed to study metal vapor and plasma formation on aluminum surfaces subjected to pulsed megagauss fields on the University of Nevada Zebra facility. The experiment is designed to study this interesting threshold for plasma formation. A current of 1 MA is pulsed along a stationary central rod to generate magnetic fields of 2-4 MG. The goal is to observe and diagnose the formation of metal vapor and plasma in the vicinity of the rod. The simple geometry enables easy access by diagnostics, which include magnetic sensors, filtered photodiode measurements, optical imaging, and laser schlieren, shadowgraphy, and interferometry. From these measurements, the magnetic field, the temperature of the surface metal plasma, the radiation field, and the growth of instabilities can be inferred. The diagnostics are time resolved to individually examine the distinct phases of heating, surface plasma formation predicted by radiation MHD modeling, and instability.