Miracle-dz/UniFAR-FTUs huggingface dataset:
Leisure Activities and Risk of Vascular Cognitive Impairment in Older Adults

``Vascular cognitive impairment'' refers to cognitive impairment caused or associated with vascular risk factors, and encompasses a cognitive spectrum ranging from mild cognitive impairment to dementia. We examined the association of leisure activity participation to risk of developing VCI in the Bronx aging study. Over 21 years, 71 of the 401 participants who were free of dementia or VCI at entry developed VCI (49 participants with VCI without dementia). We derived Cognitive and Physical Activity Scales based on frequency of leisure activity participation. A 1-point increase on the Cognitive, but not Physical Activity Scale, was associated with lower risk of VCI (hazard ratio 0.931, 95% confidence interval [CI] 0.895-0.970) in Cox analysis. Participation in cognitive but not physical leisure activities is associated with lower risk of VCI with or without dementia. Prospective studies and clinical trials are needed to define the causal role of cognitive leisure activities in influencing vascular risk for cognitive decline.
Usages d'une plateforme de TCAO par des professeurs des écoles stagiaires durant l'année scolaire

Depuis quatre ans, nous suivons le travail effectue par les professeurs des ecoles stagiaires (PE2) de l'IUFM de La Reunion sur une plate-forme de TCAO en nous appuyant sur les dossiers partages de plus haut niveau qui permettent une analyse des traces en accord avec la Theorie de l’activite. Ici, nous etudions plus precisement comment ce travail se repartit sur une annee scolaire durant laquelle les PE2 alternent les periodes de cours a l’IUFM et les periodes de stage. Nous montrons que, paradoxalement, la plate-forme est moins utilisee durant les stages que durant les periodes ou les PE2 sont a l'IUFM. L’explication est que les PE2 souhaitent une plate-forme pour mutualiser le travail durant le stage, mais que cette mutualisation se fait lors de la preparation du stage alors qu’ils sont encore a l'IUFM. Nous montrons aussi qu’en fonction du type d’activite, mutualisation, accompagnement lors des stages, etc. l’utilisation durant l’annee n’est pas la meme. Abstract: For
Effect of magnetic field on tree characteristics in silicone rubber

Silicone rubber (SiR) has been an important material widely used in the cable accessories in cross-linked polyethylene (XLPE) cables. The electrical tree is a serious threat to SiR insulation and it will cause breakdown when reaches the ground. The high carrying capacity of superconducting cable makes the magnetic flux density up to hundreds of mT around the conductor. However, the effect of high magnetic flux density on electrical tree in SiR has not been researched. In this paper, the magnetic flux density ranged from 0 to 400 mT. The electrodes were typical needle-plate electrodes. The frequency of the applied AC voltage was 50 Hz. The growth process of electrical tree was recorded by a microscope system and the pictures were taken. The experiment result indicated that the high magnetic flux density changes the tree structure and affects the growth of tree length and width.
Identifying Opinionated Sentences

Natural language processing applications that summarize or answer questions about news and other discourse need to process information about opinions, emotions, and evaluations. For example, a question answering system that could identify opinions in the news could answer questions such as the following:Was the 2002 presidential election in Zimbabwe regarded as fair? What was the world-wide reaction to the 2001 annual U.S. report on human rights?
Use of the Long and Short Forms of the Depression in the Medically Ill Questionnaire in a Spanish Population

This study sought to translate, using a back-translation procedure, and evaluate the psychometric characteristics of Depression in the Medically Ill questionnaire (DMI-18) and its short version (DMI-10) in a Spanish population. Patients with somatic disorders (N = 366) completed the translated DMI-18 and another depression questionnaire. Among these, 167 were also assessed by a mental health professional (gold standard) to test criterion validity. Furthermore, coefficient alpha for both the versions were high (>.90), and convergent validity assessed against the Beck Depression Inventory for Primary Care, the Hospital Anxiety and Depression Scale, and the Patient Health Questionnaire–9 was satisfactory (r > .74). Confirmatory factor analysis results supported the one-factor model. When compared with the gold standard, sensitivity and specificity were 93% and 73% for DMI-18 and 87% and 74% for DMI-10, respectively. Thus, both the versions are acceptable measures that can be used by nonpsychiatric professionals to detect affective comorbidities in their patients.
Angioscopic Observation of an Endoluminal Stent Graft: CT Imaging versus Angioscopic Imaging

We could observe the endoluminal stent graft (SG) following thoracic endovascular aneurysm repair (TEVAR) by a coronary artery angioscope and establish intravascular visualization of SG. The patient was a 70-year-old woman with the distal aortic arch aneurysm and the descending aortic aneurysm, and debranching TEVAR were performed. After 12 months follow up, urgent hospitalization was required for chest pain, and cardiac catheter examination with a coronary artery angioscope was performed. The endoluminal SG was observed. The observation in angioscope which is a video image is better than CT that is a still image, and observation in blood vessel or SG is possible. It may be possible to observe the endoluminal SG, allowing potential investigation of an endoleak, or the covering status of the SG with the native aortic vessel wall, or the state of intimal membrane formation in the endoluminal graft.
European air transport public service obligations: a periodic review

The ‘Third Package’ of European Union air transport liberalisation measures came into effect on 1 January 1993 and has substantially reduced the restrictions on interstate flight operations. The package of measures also includes provision for the member states to impose ‘public service obligations’ on low-density routes which were deemed necessary for the purposes of regional development. In this paper, it is this legislation which is the main focus of attention. In the second section, the background to and contents of the ‘Third Package’ are reviewed. The competitive implications of these measures are briefly outlined. In Section III, the legislation relating to public service obligation routes is critically examined. The Irish government was first to invoke this legislation and several difficulties have come to light as a result. In the final section, recommendations on improvements to the legislation are proposed, based largely on the equivalent US ‘Essential Air Services’ (EAS) programme.
Flexor Tendon Suture: A Description of Two Core Suture Techniques and the Silfverskiöld Epitendinous Suture

Flexor tendon injuries are commonly treated by orthopedic, plastic, and hand surgeons. Bunnell referred to zone 2 injuries as being in “no-man's land,” plagued by poor results after surgical repair. Over the last 30 years, a better understanding of the biology of flexor tendon injuries, advanced surgical techniques, and perhaps most important, improved rehabilitation protocols, have afforded consistently good to excellent results after surgical repair at all levels of injury. Complications such as restrictive adhesions, joint contracture, and repair rupture, although less frequent, can compromise functional recovery.
The Critical Path of Women Affected by Family Violence in Latin America

This research examined the critical path followed by women from 10 Latin American countries who suffer family violence. It identified the personal and social processes women experience as a result of their help-seeking actions and the kinds of responses found at local services. The study used an action-oriented qualitative methodology with a standard research protocol that was translated and adapted for the various ethnic groups. The results provided community actors with an understanding of the barriers women face in overcoming the obstacles, humiliation, and inadequate responses they encounter along their critical paths.
Paracoccidioidomycosis: a recently proposed classification of its clinical forms.

Many attempts have been made to define the cli­ nical forms of human paracoccidioidomycosis15. Several classifications are based on different para­ meters of the disease such as entry route (tegumentary or pulmorary15); presence or absence of signs and/or symptoms (infection vs. disease2 14); organs involved (lymphatic form; pulmonary form15); presen­ ce or absence of activity (active; latent12); type of evolution (progressive; regressive1 2 20); duration of the disease (acute; subacute; chronic4); clinical course (localised; systemic4 26); type of infection (primary; endogenous or exogenous reinfection19); presence or absence of sequelae (cor pulmonale; Addison’s disea­ se12); pathological anatomy (isolated organic form; pseudotumoral forms22) and immunohistological res­ ponse (polar forms21). This variety of criteria is an indication of the partial acceptance of most of them. This is comprehen­ sible since we still do not know where the fungus comes from and how it invades the human host, making difficult the evaluation of the early phases of the disease. In the “ Segundo Encontro sobre Paracoccidioidomicose” held in Botucatu, Brazil, in 1983, a commi­ ttee of experts* was nominated with the objective of proposing a classification of clinical forms of the disease. A questionnaire was circulated among the members and the committee reconvened at the Inter­
BCB (Benzocylcobutene) process integration for the RF passive device

For the on-chip antenna (OCA) application, the authors successful integrate the radio frequency (RF) component (inductor) by the BCB interconnect. The electrical yield of BCB interconnect is more than 80%. The peak Q-value of the inductor that was integrated by BCB interconnects is 36 at frequency 7.78GHz. At the same time, the cost and process time are reduced to half. BCB can be used in the post-process for the RF passive integration.
Different size limitations for increased transepithelial paracellular solute flux across phorbol ester and tumor necrosis factor‐treated epithelial cell sheets

By observing increases in the transepithelial paracellular permeability of a range of radiolabeled solutes and electron dense dyes, changes in molecular sieving caused by the cytokine, TNF (tumor necrosis factor), and the phorbol ester, TPA (12‐0‐tetra‐decanoylphorbol‐13‐acetate), were characterized. Using 14C‐labeled mannitol (mw 182), raffinose (mw 504), PEG (polyethylene glycol; mw 4000), and dextran (mw 10,000, 70,000 and 2,000,000), the transepithelial flux rates of these compounds were determined at the peak of the transepithelial electrical resistance (TER) changes caused by these two agents. TNF treatment resulted in increased permeability across LLC‐PK1 epithelial cell sheets only to relatively small solutes, with an upper limit of approximately 4,000 mw. The low molecular weight “ceiling” for the TNF‐treated epithelium is further evidence against TNF increasing transepithelial permeability by means of inducing nonspecific, microscopic “holes” in the epithelium, for which a “ceiling” would not exist. TPA treatment increases transepithelial paracellular permeability to a much broader range of solutes, extending well beyond 2 million mw. Transmission electron micrographs provide evidence that even the electron‐dense dye complex, ruthenium red, can cross tight junctions of TPA‐treated cell sheets. However, cationic ferritin cannot cross tight junctions of TPA‐treated cell sheets. This shows that there is an upper limit to solutes able to cross TPA‐treated cell sheets, but that this upper limit will include most proteins, which would then be able to cross tumor promoter‐exposed (protein kinase C‐activated) epithelial layers at accelerated rates. The biomedical implications for a high molecular weight cutoff in tumor promoter action in epithelial carcinogenesis, and for a low molecular weight cutoff in cytokine‐induced epithelial apoptosis in inflammation, are discussed. J. Cell. Physiol. 171:226–233, 1997. © 1997 Wiley‐Liss, Inc.
A state-by-state survey of ticks recorded from humans in the United States.

Based on tick specimens accessioned into the U.S. National Tick Collection, the species of ticks recorded as ectoparasites of humans are documented and compared for 49 U.S. states. A total of 44 tick species was recorded as parasites of humans, consisting of 11 species of soft ticks (Argasidae) and 33 species of hard ticks (Ixodidae). Four of the hard tick species are not native to the U.S. and were removed from travelers returning from foreign destinations. Therefore, we record 40 of the 84 species of U.S. ticks as ectoparasites of humans. Predictably, in the southern U.S. and Atlantic states, all active stages of the lone star tick, Amblyomma americanum (L.), were common ectoparasites of humans. Also, in the eastern U.S., adults of the American dog tick, Dermacentor variabilis (Say), and all active stages (especially adults) of the blacklegged tick, Ixodes scapularis (Say), were commonly recorded. In certain Rocky Mountain and western states, all active stages of the Rocky Mountain wood tick, Dermacentor andersoni (Stiles), predominated, whereas, in most far western states, adults of the western blacklegged tick, Ixodes pacificus Cooley and Kohls, were relatively common parasites of humans. Parasitism by Ornithodoros spp. soft ticks was mainly recorded in the western U.S. These findings, together with records of human parasitism by other tick species in the U.S., are briefly discussed with respect to tick-borne disease risk.
Comparison of Selected Reduction Methods of Bathymetric Data Obtained by Multibeam Echosounder

The publication presents a comparison of various methods to reduce datasets obtained by multibeam echo sounder. Data reduction is the process of minimizing the amount of data that needs to be stored in a data storage environment. Data reduction makes data easier and more effective for the purposes of the analysis. The authors decided to compare selected reduction method used in hydrography: GeoSwath Plus software and BathyDataBASE software. As the scale of the final product was applied 1: 2000. Selected parameters for each of the test methods have been adopted. After reduction of the points surfaces were created. In the next step these surfaces were compared and detailed analysis was conducted.
Realizability of similar formation and local control of directed multi-agent networks in discrete-time

This paper introduces a new concept called similar formation and studies the realizability condition, concerning with the existence of a protocol that has the ability to drive a directed multi-agent network to a desired formation shape. With the help of complex Laplacian, it is shown that in order to uniquely realize a similar formation in the plane, a necessary and sufficient graphical condition is that the directed multi-agent network is 2-rooted, a new type of connectivity. Moreover, a distributed control law is also derived using local measurements for the purpose of stabilizing a directed multi-agent network to a desired formation shape in discrete time, which ensures globally asymptotic stability of the closed-loop system. Simulation results are provided as well to illustrate our results.
Requirement of Fnr and NarL functions for nitrate reductase expression in Escherichia coli K-12

I used a chlC-lac operon fusion to study regulatory mutations which affect nitrate reductase expression in Escherichia coli. A NarL- mutant apparently lacks a nitrate-specific positive regulatory component. Furthermore, an fnr (nirR) mutation prevented enzyme induction under any conditions. These data are consistent with a two-step, positive control model for nitrate reductase regulation.
MiR-205 and MiR-373 Are Associated with Aggressive Human Mucinous Colorectal Cancer

Mucinous adenocarcinoma (MAC) represents a distinct histopathological entity of colorectal cancer (CRC), which is associated with disease progression and poor prognosis. Here, we found that expression levels of miR-205 and miR-373 were specifically upregulated only in patients with mucinous colon cancers, but not in CRC that lack mucinous components. To investigate the effects of miR-205 and miR-373 on intestinal epithelial cell (IEC) biology by gain- and loss-of-function experiments in a proof-of-concept approach, we chose previously established in-vitro human Caco-2-based models of differentiated, non-invasive (expressing TLR4 wild-type; termed Caco-2[WT]) versus undifferentiated, invasive (expressing TLR4 mutant D299G; termed Caco-2[D299G]) IEC. Enterocyte-like Caco-2[WT] showed low levels of miR-205 and miR-373 expression, while both miRNAs were significantly upregulated in colorectal carcinoma-like Caco-2[D299G], thus resembling the miRNA expression pattern of paired normal versus tumor samples from MAC patients. Using stable transfection, we generated miR-205- or miR-373-expressing and miR-205- or miR-373-inhibiting subclones of these IEC lines. We found that introduction of miR-205 into Caco-2[WT] led to expansion of mucus-secreting goblet cell-like cells, which was associated with induction of KLF4, MUC2 and TGFβ1 expression. Activation of miR-205 in Caco-2[WT] induced chemoresistance, while inhibition of miR-205 in Caco-2[D299G] promoted chemosensitivity. Caco-2[WT] overexpressing miR-373 showed mitotic abnormalities and underwent morphologic changes (loss of epithelial polarity, cytoskeletal reorganization, and junctional disruption) associated with epithelial-mesenchymal transition and progression to inflammation-associated colonic carcinoma, which correlated with induction of phosphorylated STAT3 and N-CADHERIN expression. Functionally, introduction of miR-373 into Caco-2[WT] mediated loss of cell-cell adhesion and increased proliferation and invasion. Reversely, inhibition of miR-373 allowed mesenchymal IEC to regain epithelial properties, which correlated with absence of neoplastic progression. Using xenografts in mice demonstrated miR-373-mediated acceleration of malignant intestinal tumor growth. In conclusion, our results provide first evidence that miR-205 and miR-373 may differentially contribute to the aggressive phenotype of MAC in CRC.
Surfactant replacement therapy

In 1959, Avery and Mead reported that lungs of infants who had died from neonatal respiratory distress syndrome (NRDS) were deficient in pulmonary surfactant. ’ This observation suggested that surfactant deficiency was critical to the pathogenesis of NRDS. The first clinical trials of replacement therapy involved administration of aerosolized dipalmitoyl phosphatidylcholine (DPPC), the major surface active phospholipid in surfactant, to infants with NRDS.2g3 Delivery of surfactant to the lungs was problematic and not measured, and the results of these trials were rather disappointing. The early studies did engender, however, systematic research on methods of surfactant delivery, the results of which form the current rationale for replacement therapy in the newborn, the topic of this review. For a discussion of metabolism, biophysics, and molecular biology of surfactant, and of surfactant replacement in the experimental animal, the reader is referred to several summaries in ~ r i n t . ~ ~
Emerging role of autophagy in kidney function, diseases and aging

Autophagy is a highly conserved process that degrades cellular long-lived proteins and organelles. Accumulating evidence indicates that autophagy plays a critical role in kidney maintenance, diseases and aging. Ischemic, toxic, immunological, and oxidative insults can cause an induction of autophagy in renal epithelial cells modifying the course of various kidney diseases. This review summarizes recent insights on the role of autophagy in kidney physiology and diseases alluding to possible novel intervention strategies for treating specific kidney disorders by modifying autophagy.
A New Multimedia Content Skimming Method Based on Speech Emphasis Extraction and Its Application to Content Variations

We propose Choco-Para, a multimedia content skimming technique; its application to a variety of content types is described. Based on automatic speech emphasis extraction, Choco-Para extracts speech attributes, prosodic parameters such as pitch, power, and speaking rate, and uses the data to estimate the degree of emphasis of each spoken phrase. By computing the degree of the emphasis curve, Choco-Para can generate a skimmed edition at an arbitrary skimming rate by selecting emphasized speech portions via dynamic threshold logic. Choco-Para uses three types of prosodic parameters and both short term and long term deviation. Experiments assess the contributions of each prosodic parameter and deviation type. They show that estimation accuracy is optimized by using both short and long term deviation with regard to pitch, power, and speaking rate. The results confirm that Choco-Para supports a wide variety of multimedia content
ACCORD : Automatic Catching and Correction of Logic Design Errors in Combinational Circuits

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A transgenic mouse model for the simultaneous monitoring of ANF and BNP gene activity during heart development and disease.

AIM The expression of Nppa (ANF) and Nppb (BNP) marks the chamber myocardium in the embryo, and both genes serve as early and accurate markers for hypertrophy and heart failure. Non-invasive visualization of Nppa-Nppb expression in living mice would enable to evaluate the disease state during the course of time in heart disease models. We sought to develop a method to assess the pattern and level of Nppa and Nppb expression within living mice. METHODS AND RESULTS A modified bacterial artificial chromosome containing a genomic segment spanning the Nppa-Nppb locus was randomly integrated into the mouse genome. Firefly Luciferase was inserted into Nppa and the red fluorescent protein gene Katushka into Nppb. Both reporters precisely recapitulated the spatio-temporal patterns of Nppa and Nppb, respectively. In a hypertrophy model (transverse aortic constriction) and myocardial infarction model (left anterior descending coronary artery occlusion), the non-invasively measured bioluminescent signal from Luciferase correlated with Nppa expression, and the intensity of red fluorescence with levels of the expression of Katushka and Nppb. After myocardial infarction, the border zone of the infarct area was readily identified by an increased intensity of Katushka fluorescence. CONCLUSIONS A genomic region sufficient to regulate the developmental pattern and stress response of Nppa and Nppb has been defined. The double reporter mice can be used for the functional imaging and investigation of cardiac hypertrophy and myocardial infarction in vivo.
Operated Klatskin tumors: A series of 22 patients in a single center in Lebanon

Aims: Klatskin tumors are the most common type of cholangiocarcinomas and they arise at the confluence of the bile ducts. The Bismuth classification divides them into four categories: I, II, IIIa/IIIb and IV. We retrospectively studied a series of 22 patients operated for Klatskin tumors and investigated the relation between clinicopathological features (size, extent of resection, bilirubin and prothrombine time (PT) levels, etc.), and outcome factors such as