Miracle-dz/UniFAR-FTUs huggingface dataset:
Modern principles in the management of nodular lymphocyte‐predominant Hodgkin lymphoma

Nodular lymphocyte‐predominant Hodgkin lymphoma (NLPHL) is a unique rare subtype of Hodgkin lymphoma (HL) which differs clinically, pathologically and biologically from classic HL, warranting a nuanced approach to treatment. CD20 expression by malignant lymphocyte‐predominant cells, a tendency for late relapses, and the risk of transformation to aggressive large B‐cell lymphoma are characteristic features with important implications for treatment and follow‐up. Recognition of histopathological variant patterns is also critical, with important implications for prognosis and treatment. The optimal management for NLPHL is unclear and opinions differ as to whether treatment paradigms should be similar to, or differ from, those for classic HL. Therapy differs for early versus advanced stage disease and for frontline versus relapsed or refractory disease. Potential treatment strategies include radiotherapy, combined modality therapy, chemotherapy, rituximab and watchful waiting. Given the excellent overall survival of NLPHL, treatment choices should be geared towards reducing long‐term toxicity and optimizing survivorship. In this review, we provide an overview of the current literature and discuss modern principles in the management of NLPHL.
"Ich habe ja was gegen die Wegwerfkultur, aber …": eine empirische Analyse der Einflussfaktoren auf die Diskrepanz zwischen Einstellung und Verhalten am Beispiel von Konsumgütern

Gemäß der Statistikbehörde Eurostat gehört Deutschland europaweit zu den Spitzenreitern in puncto Müllverursachung. Zahlreiche verbraucherpolitische Maßnahmen zielen daher auf Verhaltensänderungen der Bürger und Bürgerinnen ab. Solche Maßnahmen basieren – häufig wohl implizit – auf der Theo rie des geplanten Verhaltens (Ajzen 1991), die einen Zusammenhang zwi schen der Einstellung, der Intention und dem Verhalten einer Person unter stellt. Eine empirische und verbraucherpolitische Schwäche dieser Theo rie sind die regelmäßig feststellbaren Diskrepanzen: So werden trotz kriti scher Diskussion um die deutsche Wegwerfkultur und des großen öffentlichen Interesses an einer Reduzierung der Ressourcenverschwendung umwelt bewusste Einstel lun gen von den Verbrauchern kaum in tatsächliches Ver halten übertragen. Diese Diskrepanzen zwischen Einstellung, Intention und Verhalten sind in diesem Beitrag Gegenstand einer theoriegeleiteten empirischen Studie, deren Ergebnisse abschließend kritisch gewürdigt und daraus resultierende Handlungsempfehlungen genannt werden. Dieser Beitrag erscheint unter der Creative-Commons-Lizenz: Namensnennung – Weitergabe unter gleichen Bedingungen 3.0 Deutschland | CC BY-SA 3.0 DE Kurzform | http://creativecommons.org/licenses/by-sa/3.0/de/ Lizenztext | http://creativecommons.org/licenses/by-sa/3.0/de/legalcode 54 Helena M. Lischka
Data Acquisition and Digital Filtering for Infrasonic Records on Active Volcanoes

The development of the International Monitoring System (IMS) for the verification of the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO) has led to a rapid revival of interest in infrasound. Furthermore, the installation of low-frequency sensors at seismic sites has increased in recent years, providing researchers with large and heterogeneous data-sets in near real-time. New techniques are needed to better process all of this data and to extract meaningful information quickly for various applications. In particular, there is a need to find distinct features in the infrasonic signals that allow one to distinguish low level nuclear tests from seismic events. In this thesis three methods for feature extraction from infrasound and other types of low frequency signal data are discussed: (1) discrete wavelets transforms (DWTs); (2) time scale spectra (TSSs) using continuous wavelet transforms (CWTs); and (3) empirical mode decomposition (EMD). The dimensionality of the feature space can range from a few to thousands. For processing highdimensional data we use multi-modal data space to find low-dimensional structures. The advantage of this space is that multiple metrics of similarity are converted into one single Euclidean space. The overall goal of our research is a system for automatic identification and classification of lowfrequency signals in real-time that is easy to implement in hardware. In this thesis we present our design and implementation of the discrete wavelet transform (DWT) on FPGAs for processing a continuous flow of data to obtain optimal extraction of feature information. FPGA simulation and implementation has been realized by using the polyphase structure, the filter reuse method and techniques such as pipelining and basic operations on the QUARTUS II platform. VHDL has been used to describe the functionality of the discrete wavelet transform and ModelSim has been used for the functional verification. Advancements in electronics provide a vital new option for implementation of low-frequency smart sensors that can perform signal processing close to the sensors and transmit the data wirelessly. These smart sensors can improve the efficiency of an automatic classification system and reduce the cost of actual infrasound microphones. The design of a digital wireless data acquisition system using a QF4512 programmable signal converter from Quickfilter Technologies, a MSP430 microcontroller from Texas Instruments and a F2M03GLA Bluetooth module from Free2move for infrasonic records is also presented in this thesis. The digital wireless data acquisition system has passed extensive laboratory and field tests (e.g. with man-made explosions). A study of using a miniature 3-axis fluxgate magnetometer to get fingerprints from ferrous objects is also presented in this thesis. In this experiment, distinguishing features of iron samples of four different shapes were determined using wavelet methods. Systematic differences were observed between the signatures of the four shaped iron samples.
Cytotoxic Sesterterpenes from Thai Marine Sponge Hyrtios erectus

Four sesterterpenes, erectusolides B, C, D, and seco-manoalide-25-methyl ether, two 2-furanone derivatives, erectusfuranones A and B, together with thirteen known sesterterpenes, (6Z)-neomanoalide-24-acetate, two diastereomers of 24-O-methylmanoalide, luffariolide B, manoalide, (6E)- and (6Z)-neomanoalide, seco-manoalide, scalarafuran, 12-acetylscalarolide, 12-epi-O-deacetyl-19-deoxyscalarin, 12-epi-scalarin, and 12-O-deacetyl-12-epi-scalarin, three indole alkaloids, 5-hydroxy-1H-indole-3-carbaldehyde, hyrtiosine A, and variabine B, and one norterpene, cavernosine were isolated from the marine sponge Hyrtios erectus. Their structures were determined by means of spectroscopic methods and the absolute configurations of the asymmetric centers were determined using the modified Mosher’s method. The cytotoxic activities for the isolated compounds have been reported.
WorldLens: exploring world events through media

The goal of WorldLens is to provide a visual answer to the question: "what is happening in the world? " This thesis entails the design and development of a system that provides an exploratory view into world events across varied media types. The fundamental ideas are to take a data-driven approach by crawling a broad swath of content sources, and map the resulting data into an interactive visualization. WorldLens aims to obviate the need for an a priori search term, and instead focuses on facilitating informative discovery across news content from articles, web video, and broadcast television. Thesis Supervisor: Andrew B. Lippman Title: Associate Director & Senior Research Scientist, MIT Media Lab
Polarization Controllable Device for Simultaneous Generation of Surface Plasmon Polariton Bessel-Like Beams and Bottle Beams

Realizing multiple beam shaping functionalities in a single plasmonic device is crucial for photonic integration. Both plasmonic Bessel-like beams and bottle beams have potential applications in nanophotonics, particularly in plasmonic based circuits, near field optical trapping, and micro manipulation. Thus, it is very interesting to find new approaches for simultaneous generation of surface plasmon polariton Bessel-like beams and bottle beams in a single photonic device. Two types of polarization-dependent devices, which consist of arrays of spatially distributed sub-wavelength rectangular slits, are designed. The array of slits are specially arranged to construct an X-shaped or an IXI-shaped array, namely X-shaped device and IXI-shaped devices, respectively. Under illumination of circularly polarized light, plasmonic zero-order and first-order Bessel-like beams can be simultaneously generated on both sides of X-shaped devices. Plasmonic Bessel-like beam and bottle beam can be simultaneously generated on both sides of IXI-shaped devices. By changing the handedness of circularly polarized light, for both X-shaped and IXI-shaped devices, the positions of the generated plasmonic beams on either side of device can be dynamically interchanged.
Serodiagnosis of pulmonary tuberculosis and evaluation of two ELISA kits

Sputum microscopy plays an important role in the diagnosis of pulmonary TB. However, rapid and specific diagnostic tests are not available for the diagnosis of smear negative cases and extrapulmonary TB. ELISA helps in rapid serological diagnosis of many conditions. ELISA kits using different antigens are being used for diagnosis of TB. The objective of this study was to evaluate two TB ELISA kits Andelisa Ig G (A60) and Kreatech Ig A (KP90), in terms of their sensitivity, specificity, accuracy and predictive value in respect of their positive diagnosis. The cases for the study were newly diagnosed TB patients attending the LWSTC, SDS. Sanatorium and patients of non-tuberculous chest disease from M.S.Ramaiah Medical College Hospital, Bangalore. The controls were normal healthy blood donors from Jayadeva Institute of Cardiology, Bangalore. Serum specimens were obtained from the cases and controls and subjected to ELISA tests. Sputum specimens were collected from the cases and subjected to AFB microscopy and culture for M.tuberculosis using modified Petroff's method. The study population was divided into four groups: Group1-Controls; Group 2-Patients with non tubercular lung disease; Group 3- Newly diagnosed pulmonary TB patients; all smear negative and culture positive cases (S-C+) and Group 4- Newly diagnosed smear positive and culture positive cases of pulmonary TB (S+C+). All the specimens were subjected to ELISA test using standard protocol. Taking culture results as the gold standard, sensitivity, specificity, accuracy and predictive value of positivity were calculated. The mean titer of the controls and cases were compared and significance was tested using 't' test. A total of 317 cases were studied. The cut off point (mean + 1SD) was taken from controls. With this cut off point, it was seen that 16.2 % of the normals, 47.6% of the non-tuberculous patients, 53.9% of the smear negative culture positives and 48.2% of the smear and culture positives were declared positives using the KP90 test. A lower rate was seen among controls with the A60 ELISA indicating a higher specificity. Taking culture as the standard, the specificity was 84% using KP90 and 92% using A60.The sensitivity, accuracy and positive predictive values were 49.7%, 61.5%and 56.1% with KP90 and 48.3%, 71.3% and 75% respectively with A60. Infection with M. tuberculosis induces an antibody response, which can be detected and measured. But the antibody activity does not correlate with the severity of the disease. In this study low level of antibodies were found in many smear positive cases. Overlap of antibody levels were seen between cases and controls. Hence these serodiagnostic tests are of limited value in the diagnosis of pulmonary TB. In case of smear negative patients, till an extensive evaluation of the antibody tests are made, these tests should be interpreted with utmost caution.
FAKTOR RISIKO KEMATIAN PENDERITA SIROSIS HATI DI RSUP Dr. KARIADI SEMARANG TAHUN 2002 - 2006

Background: Liver cirrhosis was a pathological condition when liver got damaged and its function was disturbed. In Indonesia, liver cirrhosis and its complication became a heatlh problem which was hard to overcome. This was signed with the high rate of morbidity and mortality . Objective: To know the risk factors of mortality of cirrhotic patients in dr. Kariadi Hospital Semarang. Methods: The study was observational analytic with case-control approach. The case samples were cirrhotic patients who died and control samples were the ones who survived. The data was analized by using odds ratio, chi-square, t-test and Mann-Whitney. Results: The total of cirrhotic patients in the year of 2002 until 2006 was 637 people. Mortality rate was 9,7% with the most frequent cause of death was hepatic encephalophaty (45,2%). In case group, most patients were men (61,3%), aged more than 60 years old (46,8%), frequent complications were esophageal variceal bleeding and hepatic encephalophaty, had diabetes mellitus as comorbid disease (25,6%), classified as Child-Pugh C and mean score of MELD was 19,18. In control group, most patients were men (74,2%), aged between 50 to 59 years old (35,5%), the most frequent complication was esophageal variceal bleeding, had diabetes mellitus (26,7%) and hipertension (26,7%) as the most frequent comorbid disease, classified as Child-Pugh B and mean score of MELD was 16,07. Statistically, there were significant correlation between hepatic encephalophaty, esophageal variceal bleeding, septic shock, Child-Pugh and MELD score with mortality of cirrhotic patients. Conclusions: In this study, hepatic encephalophaty, septic shock and the increase of Child-Pugh and MELD score were mortality risk factors and esophageal variceal bleeding increased mortality risk of cirrhotic patients. Keywords: risk factor, mortality, liver cirrhosis
Multiple video camera calibration using EPI for city modeling

In this paper, we present an Epipolar Plane Image (EPI)based multiple video camera calibration method which enables simultaneous estimation of the multiple video cameras’ parameters and the synchronization of video data. Using our proposed method, in order to capture a large scale scene’s texture image, a user is only required to install multiple video cameras on top of his/her car without setting exact configurations, and can take a video without using a special external synchronization device. Since the optical centers of cameras are usually inside the cameras, and bringing them together is impossible, distortions inevitably occur in fused images. However, with our proposed method, the optical centers of the multiple cameras are made to coincide at one point in spatio-temporal space and thus we can fuse these images into a single one with no distortions. Another strength of our method is that we do not need any overlapping areas between images for calibration, therefore large scale scene can be efficiently captured.
Municipal Landfill as a Source of Fulvic Acids Polluting Water

The FAs (fulvic acids) belong to natural organic contaminants that are commonly found in different environments. In the process of oxidation and disinfection FAs are precursors of toxic substances, which cause a problem in many water treatment plants. In the sewage treatment plants, FAs are not biodegradable and together with purified wastewater and are discharged into surface waters. One of important source of the formation of FAs is the municipal landfill. In this thesis the authors test the amount of soluble fulvic acids present in the leachate of Barycz landfill in Krakow. The extracted FAs were subjected to a detailed analysis for the content of metals and IR spectrum analysis has also been done. Basing on elemental composition the C/O, C/H and C/N ratios have been determined. The obtained data were compared with the characteristics specified in the literature.
Prescrizione dei medicinali: aspetti normativi

Medications must be approved by AIFA or EMEA before they are allowed to be marketed in Italy. Once a drug is on the market, physicians may use it to achieve therapeutic goals other than those for which the drug was originally approved: this is referred to as off-label prescribing. Off-label prescribing has become an ubiquitous part of mainstream medical practice and it’s particularly common in oncology, paediatrics, and infectious disease. In Italy this practice is regulated by a specific normative who underlines the criteria for off-label prescription and gives a positive list of accepted in-hospital off-label uses. This article examines the Italian regulatory context concerning the prescription of off-label, from the so called “legge Di Bella” to the dispositions of “legge finanziaria 2007” and the most recent “legge finanziaria 2008”. Its aim is to help the physician to understand his responsibilities and limitations in drug off-label use.
L'apprentissage du langage chez des enfants présentant un trouble développement du langage (TDL).

Retard de langage, retard simple, retard de parole, trouble spécifique du langage, dysphasie, trouble spécifique du langage oral, etc. De nombreux termes coexistent pour parler des enfants présentant des difficultés d’acquisition de leur langue maternelle. Cette absence de consensus quant à la terminologie à adopter pour référer aux troubles langagiers est un sujet de préoccupation récurrent. En effet, la confusion induite par des appellations multiples d’une même réalité a des répercussions cliniques et des conséquences pour la recherche : la multiplicité de termes complexifie l’accès aux soins appropriés pour le patient tandis que le nombre de financements obtenus et de papiers publiés sur cette thématique sont nettement moindres que ce qui pourrait être attendu en fonction de la fréquence du trouble et de son impact sur la vie et les apprentissages de l’enfant (Bishop, 2014). Afin de faire émerger un consensus terminologique, un projet multidisciplinaire et international, Catalise (criteria and terminology applied to language impairments)
The Effect of Risk Type on ERM Effectiveness and Bank Performance: An Empirical Analysis of European Banks

Ths study aims to provide empirical evidence on the significance of risk types on the effectiveness of ERM and to the relationship between effective risk management and entities’ performance by using logistic and residual analysis in European banking sectors in the period 2013-2016. This study provides empirical evidence on the significance of credit risk and off-balance sheet exposure on the effectiveness of enterprise risk management. The significance of credit risk may arise due to the banks close supervision on their credit risks by implementing processes to monitor key risks to ensure they stay within the approved risk appetite and mitigating efforts. Additionally, the significance of off-balance-sheet items may due to the consideration that off-balance-sheet risk is the integral part of banks’ risk profile that need to be assessed carefully. While this study does not provide support to contingency theory proposed by Gordon et. al. (2009), it provides support for Kaplan and Mikes (2014) conception that risk management will be most effective when it matches the intrinsic nature and controllability of the different types of risk the organization faces. As this study only focuses on the banking sector, some standard measurement as suggested by previous studies cannot be fully measured. It is possible that these results may not be generalizable to a broader range of risk and risk management research. This study provides the empirical evidence of the significance of different type of risks on the effectiveness of ERM in the European banks.
Reflectively Prototyping a Tool for Exchanging Ideas

We describe our approach to prototyping an iteration of the Idea Manager, a tool integrated into an online science inquiry environment. Students use the Idea Manager to track ideas as they encounter new information, and reflect upon, sort, and distinguish ideas toward integrating their understanding. To explore the value of collaborative features, we designed a hybrid online/offline activity to facilitate students exchanging ideas with the Idea Manager. Based on student interviews and case studies, we identify aspects of collaboration to inform design features for enabling the meaningful exchange of ideas. Whereas most design accounts focus on the evaluative role of prototyping, this study highlights its reflective use, and its role in involving multiple stakeholders in rapid iterative cycles of establishing requirements, building alternatives, and testing. By documenting these iterative design activities, this study informs both the theory and practice of designing collaborative educational technologies.
Mesh parameterization for feature-based mesh editing applications

Athanasiadis, Theodoros. PhD, Department of Computer Science and Engineering, September 2013 Mesh parameterization for feature-based mesh editing applications Supervisor: Ioannis Fudos Mesh morphing is a technique for computing a smooth transition between two (or more) objects. Animation using deforming objects is frequently used in computer graphics for entertainment. Furthermore, smooth animation of nonrigid objects (e.g. articulated objects) can be accomplished by mesh morphing on a set of object snapshots. In recent years, mesh morphing along with cut-and-paste techniques have started to nd their way in the product design and optimization process. Nevertheless, new problems arise from the use of these techniques on these new elds. Unlike computer graphics were the primary objective is only the rendering of the results, these new applications require the intermediate results of the deformed models to be robust and respect form-features. Therefore, in this thesis we devise robust and fast techniques for the deformation of meshes which are based on mesh parameterization and respect form features. In a nutshell, we treat the problems of feature-based morphing, mesh segmentation and cut-and-paste design. Our nal goal is to incorporate these techniques in real-time applications, therefore great emphasis is given on exploiting the power of modern graphic processing units and massively parallel systems.
Arriving light control for color vision deficiency compensation using optical see-through head-mounted display

Color vision deficiency (CVD), also known as color blindness, is commonly caused by genetic disorder. Unfortunately, as of 2018, there is not yet a cure for the condition. Contact lenses and glasses with color filter are possible solutions to CVD by applying uniform changes to user's field of view (FoV). On the other hand, optical see-through head-mounted display (OST-HMD) can provide a controllable overlay to user's FoV, which could help for making a better solution. To calibrate colors in FoV of a user with CVD, methods that often used, such as the daltonization process, need light reduce feature, which makes calibrated color darker. However, recent commercially available OST-HMDs don't have a controllable way to decrease the brightness of incoming light. In this paper, we present an approach for light subtraction of OST-HMD using a transmissive LCD panel. A prototype system for achieving a controllable overlay to user's FoV with OST-HMD by using scene camera, user-perspective camera, and the transmissive LCD panel was implemented.