Miracle-dz/UniFAR-FTUs huggingface dataset:
What is next for the study of non-democracy?

The vast majority of the world's population has always had limited access to political (and economic) institutions. Yet until recently the overwhelming share of intellectual effort in political economy, if not always new institutional economics, was devoted to the study of mature democracies. This imbalance has begun to be reversed, and with vigor. Much of the contemporary literature on nondemocracy falls into two broad areas of inquiry: a) the analysis of formal institutions such as elections, parties, and legislatures, and b) the study of autocratic control, typically through the manipulation of beliefs. Scholars of NIE will recognize in this characterization a familiar divide between formal institutions, on the one hand, and social norms and beliefs, on the other. From my perspective, the most promising opportunities for research lie in a truly comparative analysis of the formal institutions of nondemocracy and the study of how these institutions interact with social norms and practices.
The accuracy of measures of institutional trust in household surveys: Evidence from the oecd trust database

A key policy concern in recent years has been the decline in levels of trust by citizen in public institutions. Trust is one of the foundations upon which the legitimacy and sustainability of political systems are built. It is crucial to the implementation of a wide range of policies and influences people’s behavioural responses to such policies. However, despite its acknowledged importance, trust in public institutions is poorly understood and is not consistently measured across OECD countries. The OECD Trust Database brings together information from a wide range of different household surveys containing measures of trust and combines this with information on other social and economic outcomes. The size of the database and range of covariates make it possible to identify the underlying patterns captured by survey based measures of trust in institutions and systematically test the accuracy (i.e. reliability and validity) of these measures. Reliability is tested by examining the consistency of measures of institutional trust across different surveys and between different waves of the same survey. Validity is harder to test than reliability. It is however possible to examine the construct validity of institutional trust measures by looking at whether these measures show the expected correlation with other social and economic variables on a cross-country basis. Analysis of item-specific non-response rates provides important additional information on the face validity of institutional trust measures.
Optimized Plane Wave Imaging for Fast and High-Quality Ultrasound Imaging.

This paper presents a method for optimizing parameters affecting the image quality in plane wave imaging. More specifically, the number of emissions and steering angles is optimized to attain the best images with the highest frame rate possible. The method is applied to a specific problem, where image quality for a λ -pitch transducer is compared with a λ /2-pitch transducer. Grating lobe artifacts for λ -pitch transducers degrade the contrast in plane wave images, and the impact on frame rate is studied. Field II simulations of plane wave images are made for all combinations of the parameters, and the optimal setup is selected based on Pareto optimality. The optimal setup for a simulated 4.1-MHz λ -pitch transducer uses 61 emissions and a maximum steering angle of 20° for depths from 0 to 60 mm. The achieved lateral full-width at half-maximum (FWHM) is 1. 5λ and the contrast is -29 dB for a scatterer at 9 mm ( 24λ ). Using a λ /2-pitch transducer and only 21 emissions within the same angle range, the image quality is improved in terms of contrast, which is -37 dB. For imaging in regions deeper than 25 mm ( 66λ ), only 21 emissions are optimal for both the transducers, resulting in a -36 dB contrast at 34 mm ( 90λ ). Measurements are performed using the experimental SARUS scanner connected to a λ -pitch and λ /2-pitch transducer. A wire phantom and a tissue mimicking phantom containing anechoic cysts are scanned and show the performance using the optimized sequences for the transducers. FWHM is 1. 6λ and contrast is -25 dB for a wire at 9 mm using the λ -pitch transducer. For the λ /2-pitch transducer, contrast is -29 dB. In vivo scans of the carotid artery of a healthy volunteer show improved contrast and present fewer artifacts, when using the λ /2-pitch transducer compared with the λ -pitch. It is demonstrated with a frame rate, which is three times higher for the λ /2-pitch transducer.
Steroid Hormone Regulation and Tissue-Specific Expression of the Human GnRH Gene in Cell Culture and Transgenic Animals

In order to study the molecular mechanisms involved in the control of GnRH gene expression, the human GnRH gene was cloned and characterized. The gene was expressed in cells obtained from CNS tumors in transgenic mice generated utilizing 1131 bp of 5' flanking GnRH DNA fused to the simian virus 40 large T antigen. We have shown a stimulatory estrogen response element in the human GnRH gene by transient transfection studies. DNase I footprinting and an avidinbiotin DNA binding assay demonstrated that the human GnRH gene bound ER. The GN cell line was found to have nuclear ERs utilizing an 125I estradiol binding study and by in situ hybridization histochemistry. In order to study GnRH expression in vivo, either 5000 or 484 bp of GnRH flanking DNA was fused to the luciferase (Luc) reporter gene, and transgenic mice generated. Expression in the transgenic animals was found in the hypothalamus of animals bearing the -5000Luc transgene, but not in animals bearing the -484Luc transgene. The transgenic mice expressing the -5000Luc gene were gonadectomized resulting in a 20-30% increase in hypothalamic Luc expression in the males and a 65% increase in females, while mice who were gonadectomized and replaced with testosterone (males) or E2 (females) showed a 50% decrease in Luc expression over control levels. Thus, these studies present in vitro evidence of E2 modulation of GnRH gene expression and an in vivo model in which sensitive studies of GnRH regulation and expression can be performed.
The Perception of Syllable Affiliation of Singleton Stops in Repetitive Speech

Stetson (1951) noted that repeating singleton coda consonants at fast speech rates makes them be perceived as onset consonants affiliated with a following vowel. The current study documents the perception of rate-induced resyllabification, as well as what temporal properties give rise to the perception of syllable affiliation. Stimuli were extracted from a previous study of repeated stop + vowel and vowel + stop syllables (de Jong, 2001a, 2001b). Forced-choice identification tasks show that slow repetitions are clearly distinguished. As speakers increase rate, they reach a point after which listeners disagree as to the affiliation of the stop. This pattern is found for voiced and voiceless consonants using different stimulus extraction techniques. Acoustic models of the identifications indicate that the sudden shift in syllabification occurs with the loss of an acoustic hiatus between successive syllables. Acoustic models of the fast rate identifications indicate various other qualities, such as consonant voicing, affect the probability that the consonants will be perceived as onsets. These results indicate a model of syllabic affiliation where specific juncture-marking aspects of the signal dominate parsing, and in their absence other differences provide additional, weaker cues to syllabic affiliation.
Evaluation of antagonist coactivation strategies elicited from electrically stimulated muscles under load-moving conditions

Muscle coactivation strategies that produce ankle dorsiflexion and plantar flexion were elicited by electrical stimulation of the tibialis anterior (TA) and soleus (SOL) muscles of the cat, and examined under several loading conditions. Four different load types were used: free-limb motion (no load), flywheel, and 2 pendulums, each with a different lever arm. Three types of coactivation strategies were considered. The first coactivation strategy consisted of antagonist activity that decreased as the agonist activity increased. The second strategy consisted of increasing antagonist activity with increasing agonist activity. And, in the third strategy, antagonist coactivation decreased at low force levels, then increased at high force levels. The three strategies were evaluated based on the joint angle's peak-to-peak movement and its ability to track a linear input command given by the correlation coefficient of the output signal versus linear input. Results showed that increasing antagonist activity resulted in decreasing peak-to-peak angle and a decreased signal tracking capability for each load condition. The latter, however, was not as obvious in the flywheel load (as compared with free-moving and pendulum conditions). A decreasing peak-to-peak torque for pendulum loads was also observed with increasing antagonist activity. In all loading conditions, maximal peak-to-peak angle and torque were present, when a moderate degree of antagonist activity was engaged, and signal tracking capability improved with earlier engagement of the antagonist muscles. It is suggested that strategies using a combination of low-level coactivation, as described in the physiological literature and previous functional electrical stimulation (FES) studies, could satisfactorily address the issues of controllability and efficiency while maintaining long-term joint integrity.
The Competitive Effects of Performance-Enhancing Drugs: MLB in the Posttesting Era

Using estimates of Major League Baseball (MLB) financials from Forbes, we conduct a cost–benefit analysis of performance-enhancing drug (PED) testing. Player PED suspensions are shown to have lowered franchise values by statistically and economically significant margins through negative impacts on teams’ nongate revenues and expected future profit growth. Testing, however, also increased competitive balance through reductions in player costs which compressed the distribution of team wins per dollar. Finally, we estimate the number of PED suspensions per season which balances the costs and benefits of testing at the league and team levels and compare it to MLB’s current policy.
Pharmacokinetic Variability of Four Newer Antiepileptic Drugs, Lamotrigine, Levetiracetam, Oxcarbazepine, and Topiramate: A Comparison of the Impact of Age and Comedication

Background: Newer antiepileptic drugs (AEDs) are widely used in patients with epilepsy. There is still insufficient documentation regarding pharmacokinetic variability of these AEDs in different patient groups. Purpose: The purpose of this study was to compare age and comedication as factors contributing to pharmacokinetic variability between 4 newer AEDs (lamotrigine, levetiracetam, oxcarbazepine, and topiramate) among patients with refractory epilepsy. Methods: Data regarding age, gender, use of AEDs, daily doses, and serum concentration measurements were retrieved from a therapeutic drug monitoring database, from patients admitted to the National Center for Epilepsy, Norway, 2007–2008. Results: In total, 1050 patients were included, 111 younger children (2–9 years), 137 older children (10–17 years), 720 adults (18–64 years), 82 elderly (65–93 years). Fifty percent of the patients were prescribed polytherapy, in 88 different combinations. The interindividual pharmacokinetic variability was extensive, as illustrated by a 10-fold variability in serum concentration compared with dose. Age affected the apparent clearance of levetiracetam to the largest extent, as shown by a 60% increase in younger children and a 40% reduction in the elderly, respectively, compared with adults. Comedication altered the clearance of lamotrigine to the greatest extent ±70% because it is affected by both enzyme inducers and inhibitors. Hepatic enzyme inducers increased the clearance of levetiracetam and topiramate by 25% and oxcarbazepine by 75%. Valproic acid reduced the clearance of topiramate by 25%. Conclusion: Age and comedication are important contributors to pharmacokinetic variability. Age had the greatest impact on levetiracetam, and comedication affected the clearance of each of the 4 AEDs investigated in this study. Pharmacokinetic drug interactions must be carefully considered when multidrug therapies are prescribed. Therapeutic drug monitoring is a valuable tool for individualizing AED therapy.
Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice.

PURPOSE Recent studies suggest that exchange of macrophage phenotype (M1/M2) in adipose tissue is associated with chronic low-grade inflammation in obesity. M1 macrophages enhance a chronic inflammatory state in adipose tissues, whereas M2 macrophages inhibit it. Although exercise training might inhibit pro-inflammatory cytokine gene expression in adipose tissue, it remains unclear whether exercise training affects the phenotypic switch of macrophage polarization in adipose tissue. Therefore, we inveStigated the effect of exercise training on the macrophage phenotypic switch in adipose tissue in high-fat-induced obese mice. METHODS Male C57BL/6 mice were divided into four groups; normal diet (ND) control (n=7), ND exercise (n=7), high-fat-diet (HFD) control (n=12), and HFD exercise (n=12) groups. All exercised mice ran on a treadmill at 12-20 m/min for 60 min/day for 16 weeks. Tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, F4/80, monocyte chemotactic protein (MCP)-1, CXCL14, inter-cellular adhesion molecule (ICAM)-1, vascular-cellular adhesion molecule (VCAM)-1, CD11c, CD163 and toll-like receptor (TLR)4 mRNA expressions in adipose tissue were evaluated by real time-RT-PCR. RESULTS In HFD mice, exercise training did not induce loss of body or adipose tissue mass, exercise training nevertheless markedly inhibited TNF-alpha and F4/80 mRNA expression in adipose tissue. The exercise training attenuated HFD-induced increase in ICAM-1 mRNA expression, but not MCP-1, CXCL14 and VCAM-1 mRNA expressions. In addition, increased CD11c mRNA expression, which is a M1 macrophage specific marker, with HFD treatment was attenuated by exercise training. In contrast, although the mRNA expression of CD163, a M2 macrophage specific marker, in adipose tissue was significantly decreased by HFD, the exercise training significantly increased its expression. Also, the higher mRNA expression of TLR4, which induces pro-inflammatory cytokine production after fatty acid recognition, was strongly inhibited by the exercise training in HFD mice. CONCLUSION Exercise training might induce the phenotypic switching from M1 macrophage to M2 macrophage in obese adipose tissue besides inhibiting M1 macrophage infiltration into adipose tissue. Therefore, chronic exercise might contribute to inhibit inflammation in adipose tissue via down regulation of TLR4.
Modification of foot-and-mouth disease virus O1 Caseros after serial passages in the presence of antiviral polyclonal sera

Foot-and-mouth disease virus (FMDV) shows a remarkable antigenic variability and, like other RNA viruses, presents a high rate of mutation. It has been proposed that selection exerted by antibodies of the host could play a major role in the rapid evolution of FMDV. The present work reports the selection of FMDV antibody-resistant (Nr) populations after serial passages of a cloned FMDV O1 Caseros strain on secondary monolayers of bovine kidney cells in the presence of subneutralizing antiviral polyclonal sera (APS). After a limited number of passages, i.e., 29, under selective pressure, the virus population showed the following characteristics: (i) increased resistance to neutralization by APS (Nr), (ii) altered electrophoretic mobility of its structural viral proteins (VP1), and (iii) alterations at the RNA nucleotide sequence that codes for the major antigenic site of VP1. These acquired characteristics were detected at passage 15 and remained unmodified throughout successive passages. These results document a rapid selection and fixation of specific mutations in response to immunological pressure. In addition, the findings that (i) mutations not related to APS selection were not detected and (ii) after 29 passages at a high multiplicity of infection without immunological pressure, the RNA sequence that codes for VP1 remained unmodified clearly demonstrated that FMDV O1 Caseros presents in vitro a remarkable unexpected genetic stability.
Epidemiology of pertussis in French hospitals in 1993 and 1994: thirty years after a routine use of vaccination.

BACKGROUND Despite widespread vaccination during 30 years, the hypothesis of a resurgence of pertussis in France has been raised by outbreaks and sporadic case reports. No surveillance data were available after 1985. METHODS A survey was undertaken in 1993 and 1994 in a pediatric hospital network able to confirm cases; the network (22 hospitals) represents 19.6% of pediatric admissions in France. Case definition included clinical (> or = 21 days of paroxysmal cough), laboratory-confirmed (culture or serology by immunoblot) or epidemiologically confirmed pertussis (documented contact with a laboratory-confirmed case). The pattern of transmission was studied in the household. Vaccine status was obtained from health records. RESULTS during a 15-month period 560 cases (316 index cases, 244 household contact cases) were reported; 49% of index cases and 20% of contact cases were confirmed by culture and/or serology. Sixty-five percent of index cases were younger than 1 year of age (the incidence in this age group could be estimated to be 95/100000) and 66% were hospitalized for a mean duration of 2 weeks. Infection was acquired from parents (34%) and siblings (46%). Seventy-three percent of index cases were unvaccinated. CONCLUSIONS Although pertussis vaccination coverage is very high in France, the organism is still circulating, affecting, within the pediatric population, mostly non- or incompletely vaccinated infants. These results strongly support the importance of adhering to the immunization schedule and suggest introducing booster dose(s) to prolong vaccine immunity and reduce the exposure to Bordetella pertussis of infants too young to be immunized.
Women and the glass ceiling in the community of Madrid hotel industry

The hotel industry labour market has a strong female presence, although women have limited access to management positions. The gender gap in the industry must be identified in order to overcome it. This research is based on a census designed to analyse the participation of women in management positions at the corporate headquarters of hotel chains and 3, 4 and 5 star hotels (independent and related to a chain) in the community of Madrid. The study concludes that there is a glass ceiling due to the male dominance of management and the stereotyping of certain positions (vertical and horizontal segregation). Nevertheless, a change in the trend has been observed and new positions have appeared as a result of ITCs.
Psychometric Properties of the Deep Muscle Contraction Scale for Assessment of the Drawing‐in Maneuver in Patients With Chronic Nonspecific Low Back Pain

•STUDY DESIGN: A prospective cohort study. •BACKGROUND: Motor control dysfunctions have been commonly reported in patients with chronic nonspecific low back pain (LBP). Physical therapists need clinical tools with adequate psychometric properties to assess such patients in clinical practice. The deep muscle contraction (DMC) scale is a clinical rating scale for assessing patients' ability to voluntarily contract deep abdominal muscles. •OBJECTIVES: To investigate the intrarater reliability, floor and ceiling effects, internal and external responsiveness, and correlation analysis (with ultrasound measures) of the DMC scale in patients with chronic nonspecific LBP undergoing a lumbar stabilization exercise program. •METHODS: Sixty‐two patients with chronic nonspecific LBP were included. At baseline, self‐report questionnaires were administered to patients and a trained assessor evaluated abdominal muscle recruitment with the DMC scale and ultrasound imaging. Four ratios of the change in abdominal muscle thickness between the resting and contracted states were calculated through the ultrasound measures. After 1 week, the same ultrasound measures and DMC scale were collected again for the reliability analysis. The proportions of patients with the lowest and highest scores on the DMC scale were calculated to investigate floor and ceiling effects. All patients underwent a lumbar stabilization program, administered twice a week for 8 weeks. After the treatment period, all measures were collected again, with the addition of the global perceived effect scale, to assess the internal and external responsiveness of the measures. Correlation coefficients between ultrasound ratios and DMC scale total and subscale scores were also calculated. •RESULTS: The intrarater reliability of the DMC scale and the 4 ratios of abdominal muscle thickness varied from moderate to excellent. The DMC scale showed no floor or ceiling effects. Results for internal responsiveness of the DMC scale showed large effect sizes (2.26; 84% confidence interval [CI]: 2.06, 2.45), whereas the external responsiveness was below the proposed threshold (area under the curve = 0.54; 95% CI: 0.39, 0.68). Fair and significant correlations between some ultrasound ratios and DMC subscales were found. •CONCLUSION: The DMC scale was demonstrated to be a reliable tool, with no ceiling and floor effects, and to detect change in the ability to contract the deep abdominal muscles after a lumbar stabilization exercise program, but with low accuracy for estimating patient‐perceived clinical outcome. •KEY WORDS: abdominal muscles, low back pain, motor control, ultrasound imaging
Determinants of transaction activity in commercial real estate markets: evidence from European and Asia-Pacific countries

Abstract Variations in transaction activity between commercial real estate markets could have important implications for investment strategies and pricing. We consider why turnover rates, a common liquidity proxy, vary between countries and over time. We examine 38 countries in Europe and Asia-Pacific over the period 2000–2014. A conceptual framework is discussed prior to estimation of panel models that use turnover rates as the dependent variable. Our results indicate that the size and wealth of a country, the risk associated with that country and the performance of its commercial real estate market are significant factors that explain transaction activity. The quality of property rights is also an important factor.